data_9EJP
# 
_entry.id   9EJP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EJP         pdb_00009ejp 10.2210/pdb9ejp/pdb 
WWPDB D_1000290638 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EJP 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              l.halabelian@utoronto.ca 
_pdbx_contact_author.name_first         Levon 
_pdbx_contact_author.name_last          Halabelian 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4361-3619 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zeng, H.'                             1  ? 
'Ahmad, H.'                            2  ? 
'Wang, X.'                             3  ? 
'Sun, J.'                              4  ? 
'Dong, A.'                             5  ? 
'Seitova, A.'                          6  ? 
'Arrowsmith, C.H.'                     7  ? 
'Edwards, A.M.'                        8  ? 
'Peng, H.'                             9  ? 
'Halabelian, L.'                       10 ? 
'Structural Genomics Consortium (SGC)' 11 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To be published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of WDR91 in complex with XS838489' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zeng, H.'                             1  ? 
primary 'Ahmad, H.'                            2  ? 
primary 'Wang, X.'                             3  ? 
primary 'Sun, J.'                              4  ? 
primary 'Dong, A.'                             5  ? 
primary 'Seitova, A.'                          6  ? 
primary 'Arrowsmith, C.H.'                     7  ? 
primary 'Edwards, A.M.'                        8  ? 
primary 'Peng, H.'                             9  ? 
primary 'Halabelian, L.'                       10 ? 
primary 'Structural Genomics Consortium (SGC)' 11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'WD repeat-containing protein 91'                                                                          
41064.477 1  ? ? 'UNP residues 392-747' ? 
2 non-polymer syn 'N-[(5R)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda~6~-benzothiepin-5-yl]-2-hydroxyquinoxaline-6-carboxamide' 
383.421   1  ? ? ?                      ? 
3 non-polymer syn 'UNKNOWN ATOM OR ION'                                                                                      ? 1  
? ? ?                      ? 
4 water       nat water                                                                                                      
18.015    93 ? ? ?                      ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        WDR91 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHSSGRENLYFQGPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPL
LSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSK
GMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFS
YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYK
LGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHSSGRENLYFQGPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPL
LSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSK
GMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFS
YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYK
LGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-[(5R)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda~6~-benzothiepin-5-yl]-2-hydroxyquinoxaline-6-carboxamide' A1BIW 
3 'UNKNOWN ATOM OR ION'                                                                                      UNX   
4 water                                                                                                      HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  TYR n 
1 16  PHE n 
1 17  GLN n 
1 18  GLY n 
1 19  PRO n 
1 20  GLU n 
1 21  GLN n 
1 22  PRO n 
1 23  PHE n 
1 24  ILE n 
1 25  VAL n 
1 26  LEU n 
1 27  GLY n 
1 28  GLN n 
1 29  GLU n 
1 30  GLU n 
1 31  TYR n 
1 32  GLY n 
1 33  GLU n 
1 34  HIS n 
1 35  HIS n 
1 36  SER n 
1 37  SER n 
1 38  ILE n 
1 39  MET n 
1 40  HIS n 
1 41  CYS n 
1 42  ARG n 
1 43  VAL n 
1 44  ASP n 
1 45  CYS n 
1 46  SER n 
1 47  GLY n 
1 48  ARG n 
1 49  ARG n 
1 50  VAL n 
1 51  ALA n 
1 52  SER n 
1 53  LEU n 
1 54  ASP n 
1 55  VAL n 
1 56  ASP n 
1 57  GLY n 
1 58  VAL n 
1 59  ILE n 
1 60  LYS n 
1 61  VAL n 
1 62  TRP n 
1 63  SER n 
1 64  PHE n 
1 65  ASN n 
1 66  PRO n 
1 67  ILE n 
1 68  MET n 
1 69  GLN n 
1 70  THR n 
1 71  LYS n 
1 72  ALA n 
1 73  SER n 
1 74  SER n 
1 75  ILE n 
1 76  SER n 
1 77  LYS n 
1 78  SER n 
1 79  PRO n 
1 80  LEU n 
1 81  LEU n 
1 82  SER n 
1 83  LEU n 
1 84  GLU n 
1 85  TRP n 
1 86  ALA n 
1 87  THR n 
1 88  LYS n 
1 89  ARG n 
1 90  ASP n 
1 91  ARG n 
1 92  LEU n 
1 93  LEU n 
1 94  LEU n 
1 95  LEU n 
1 96  GLY n 
1 97  SER n 
1 98  GLY n 
1 99  VAL n 
1 100 GLY n 
1 101 THR n 
1 102 VAL n 
1 103 ARG n 
1 104 LEU n 
1 105 TYR n 
1 106 ASP n 
1 107 THR n 
1 108 GLU n 
1 109 ALA n 
1 110 LYS n 
1 111 LYS n 
1 112 ASN n 
1 113 LEU n 
1 114 CYS n 
1 115 GLU n 
1 116 ILE n 
1 117 ASN n 
1 118 ILE n 
1 119 ASN n 
1 120 ASP n 
1 121 ASN n 
1 122 MET n 
1 123 PRO n 
1 124 ARG n 
1 125 ILE n 
1 126 LEU n 
1 127 SER n 
1 128 LEU n 
1 129 ALA n 
1 130 CYS n 
1 131 SER n 
1 132 PRO n 
1 133 ASN n 
1 134 GLY n 
1 135 ALA n 
1 136 SER n 
1 137 PHE n 
1 138 VAL n 
1 139 CYS n 
1 140 SER n 
1 141 ALA n 
1 142 ALA n 
1 143 ALA n 
1 144 PRO n 
1 145 SER n 
1 146 LEU n 
1 147 THR n 
1 148 SER n 
1 149 GLN n 
1 150 VAL n 
1 151 ASP n 
1 152 PHE n 
1 153 SER n 
1 154 ALA n 
1 155 PRO n 
1 156 ASP n 
1 157 ILE n 
1 158 GLY n 
1 159 SER n 
1 160 LYS n 
1 161 GLY n 
1 162 MET n 
1 163 ASN n 
1 164 GLN n 
1 165 VAL n 
1 166 PRO n 
1 167 GLY n 
1 168 ARG n 
1 169 LEU n 
1 170 LEU n 
1 171 LEU n 
1 172 TRP n 
1 173 ASP n 
1 174 THR n 
1 175 LYS n 
1 176 THR n 
1 177 MET n 
1 178 LYS n 
1 179 GLN n 
1 180 GLN n 
1 181 LEU n 
1 182 GLN n 
1 183 PHE n 
1 184 SER n 
1 185 LEU n 
1 186 ASP n 
1 187 PRO n 
1 188 GLU n 
1 189 PRO n 
1 190 ILE n 
1 191 ALA n 
1 192 ILE n 
1 193 ASN n 
1 194 CYS n 
1 195 THR n 
1 196 ALA n 
1 197 PHE n 
1 198 ASN n 
1 199 HIS n 
1 200 ASN n 
1 201 GLY n 
1 202 ASN n 
1 203 LEU n 
1 204 LEU n 
1 205 VAL n 
1 206 THR n 
1 207 GLY n 
1 208 ALA n 
1 209 ALA n 
1 210 ASP n 
1 211 GLY n 
1 212 VAL n 
1 213 ILE n 
1 214 ARG n 
1 215 LEU n 
1 216 PHE n 
1 217 ASP n 
1 218 MET n 
1 219 GLN n 
1 220 GLN n 
1 221 HIS n 
1 222 GLU n 
1 223 CYS n 
1 224 ALA n 
1 225 MET n 
1 226 SER n 
1 227 TRP n 
1 228 ARG n 
1 229 ALA n 
1 230 HIS n 
1 231 TYR n 
1 232 GLY n 
1 233 GLU n 
1 234 VAL n 
1 235 TYR n 
1 236 SER n 
1 237 VAL n 
1 238 GLU n 
1 239 PHE n 
1 240 SER n 
1 241 TYR n 
1 242 ASP n 
1 243 GLU n 
1 244 ASN n 
1 245 THR n 
1 246 VAL n 
1 247 TYR n 
1 248 SER n 
1 249 ILE n 
1 250 GLY n 
1 251 GLU n 
1 252 ASP n 
1 253 GLY n 
1 254 LYS n 
1 255 PHE n 
1 256 ILE n 
1 257 GLN n 
1 258 TRP n 
1 259 ASN n 
1 260 ILE n 
1 261 HIS n 
1 262 LYS n 
1 263 SER n 
1 264 GLY n 
1 265 LEU n 
1 266 LYS n 
1 267 VAL n 
1 268 SER n 
1 269 GLU n 
1 270 TYR n 
1 271 SER n 
1 272 LEU n 
1 273 PRO n 
1 274 SER n 
1 275 ASP n 
1 276 ALA n 
1 277 THR n 
1 278 GLY n 
1 279 PRO n 
1 280 PHE n 
1 281 VAL n 
1 282 LEU n 
1 283 SER n 
1 284 GLY n 
1 285 TYR n 
1 286 SER n 
1 287 GLY n 
1 288 TYR n 
1 289 LYS n 
1 290 GLN n 
1 291 VAL n 
1 292 GLN n 
1 293 VAL n 
1 294 PRO n 
1 295 ARG n 
1 296 GLY n 
1 297 ARG n 
1 298 LEU n 
1 299 PHE n 
1 300 ALA n 
1 301 PHE n 
1 302 ASP n 
1 303 SER n 
1 304 GLU n 
1 305 GLY n 
1 306 ASN n 
1 307 TYR n 
1 308 MET n 
1 309 LEU n 
1 310 THR n 
1 311 CYS n 
1 312 SER n 
1 313 ALA n 
1 314 THR n 
1 315 GLY n 
1 316 GLY n 
1 317 VAL n 
1 318 ILE n 
1 319 TYR n 
1 320 LYS n 
1 321 LEU n 
1 322 GLY n 
1 323 GLY n 
1 324 ASP n 
1 325 GLU n 
1 326 LYS n 
1 327 VAL n 
1 328 LEU n 
1 329 GLU n 
1 330 SER n 
1 331 CYS n 
1 332 LEU n 
1 333 SER n 
1 334 LEU n 
1 335 GLY n 
1 336 GLY n 
1 337 HIS n 
1 338 ARG n 
1 339 ALA n 
1 340 PRO n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 VAL n 
1 345 ASP n 
1 346 TRP n 
1 347 SER n 
1 348 THR n 
1 349 ALA n 
1 350 MET n 
1 351 ASP n 
1 352 CYS n 
1 353 GLY n 
1 354 THR n 
1 355 CYS n 
1 356 LEU n 
1 357 THR n 
1 358 ALA n 
1 359 SER n 
1 360 MET n 
1 361 ASP n 
1 362 GLY n 
1 363 LYS n 
1 364 ILE n 
1 365 LYS n 
1 366 LEU n 
1 367 THR n 
1 368 THR n 
1 369 LEU n 
1 370 LEU n 
1 371 ALA n 
1 372 HIS n 
1 373 LYS n 
1 374 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   374 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'WDR91, HSPC049' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BIW non-polymer         . 
'N-[(5R)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda~6~-benzothiepin-5-yl]-2-hydroxyquinoxaline-6-carboxamide' ? 'C19 H17 N3 O4 S' 
383.421 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
UNX   non-polymer         . 'UNKNOWN ATOM OR ION' ? ?                 ?       
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   374 ?   ?   ?   A . n 
A 1 2   HIS 2   375 ?   ?   ?   A . n 
A 1 3   HIS 3   376 ?   ?   ?   A . n 
A 1 4   HIS 4   377 ?   ?   ?   A . n 
A 1 5   HIS 5   378 ?   ?   ?   A . n 
A 1 6   HIS 6   379 ?   ?   ?   A . n 
A 1 7   HIS 7   380 ?   ?   ?   A . n 
A 1 8   SER 8   381 ?   ?   ?   A . n 
A 1 9   SER 9   382 ?   ?   ?   A . n 
A 1 10  GLY 10  383 ?   ?   ?   A . n 
A 1 11  ARG 11  384 ?   ?   ?   A . n 
A 1 12  GLU 12  385 ?   ?   ?   A . n 
A 1 13  ASN 13  386 ?   ?   ?   A . n 
A 1 14  LEU 14  387 ?   ?   ?   A . n 
A 1 15  TYR 15  388 ?   ?   ?   A . n 
A 1 16  PHE 16  389 ?   ?   ?   A . n 
A 1 17  GLN 17  390 ?   ?   ?   A . n 
A 1 18  GLY 18  391 ?   ?   ?   A . n 
A 1 19  PRO 19  392 ?   ?   ?   A . n 
A 1 20  GLU 20  393 ?   ?   ?   A . n 
A 1 21  GLN 21  394 394 GLN GLN A . n 
A 1 22  PRO 22  395 395 PRO PRO A . n 
A 1 23  PHE 23  396 396 PHE PHE A . n 
A 1 24  ILE 24  397 397 ILE ILE A . n 
A 1 25  VAL 25  398 398 VAL VAL A . n 
A 1 26  LEU 26  399 399 LEU LEU A . n 
A 1 27  GLY 27  400 400 GLY GLY A . n 
A 1 28  GLN 28  401 401 GLN GLN A . n 
A 1 29  GLU 29  402 402 GLU GLU A . n 
A 1 30  GLU 30  403 403 GLU GLU A . n 
A 1 31  TYR 31  404 404 TYR TYR A . n 
A 1 32  GLY 32  405 405 GLY GLY A . n 
A 1 33  GLU 33  406 406 GLU GLU A . n 
A 1 34  HIS 34  407 407 HIS HIS A . n 
A 1 35  HIS 35  408 408 HIS HIS A . n 
A 1 36  SER 36  409 409 SER SER A . n 
A 1 37  SER 37  410 410 SER SER A . n 
A 1 38  ILE 38  411 411 ILE ILE A . n 
A 1 39  MET 39  412 412 MET MET A . n 
A 1 40  HIS 40  413 413 HIS HIS A . n 
A 1 41  CYS 41  414 414 CYS CYS A . n 
A 1 42  ARG 42  415 415 ARG ARG A . n 
A 1 43  VAL 43  416 416 VAL VAL A . n 
A 1 44  ASP 44  417 417 ASP ASP A . n 
A 1 45  CYS 45  418 418 CYS CYS A . n 
A 1 46  SER 46  419 419 SER SER A . n 
A 1 47  GLY 47  420 420 GLY GLY A . n 
A 1 48  ARG 48  421 421 ARG ARG A . n 
A 1 49  ARG 49  422 422 ARG ARG A . n 
A 1 50  VAL 50  423 423 VAL VAL A . n 
A 1 51  ALA 51  424 424 ALA ALA A . n 
A 1 52  SER 52  425 425 SER SER A . n 
A 1 53  LEU 53  426 426 LEU LEU A . n 
A 1 54  ASP 54  427 427 ASP ASP A . n 
A 1 55  VAL 55  428 428 VAL VAL A . n 
A 1 56  ASP 56  429 429 ASP ASP A . n 
A 1 57  GLY 57  430 430 GLY GLY A . n 
A 1 58  VAL 58  431 431 VAL VAL A . n 
A 1 59  ILE 59  432 432 ILE ILE A . n 
A 1 60  LYS 60  433 433 LYS LYS A . n 
A 1 61  VAL 61  434 434 VAL VAL A . n 
A 1 62  TRP 62  435 435 TRP TRP A . n 
A 1 63  SER 63  436 436 SER SER A . n 
A 1 64  PHE 64  437 437 PHE PHE A . n 
A 1 65  ASN 65  438 438 ASN ASN A . n 
A 1 66  PRO 66  439 439 PRO PRO A . n 
A 1 67  ILE 67  440 440 ILE ILE A . n 
A 1 68  MET 68  441 441 MET MET A . n 
A 1 69  GLN 69  442 442 GLN GLN A . n 
A 1 70  THR 70  443 443 THR THR A . n 
A 1 71  LYS 71  444 444 LYS LYS A . n 
A 1 72  ALA 72  445 445 ALA ALA A . n 
A 1 73  SER 73  446 446 SER SER A . n 
A 1 74  SER 74  447 447 SER SER A . n 
A 1 75  ILE 75  448 448 ILE ILE A . n 
A 1 76  SER 76  449 449 SER SER A . n 
A 1 77  LYS 77  450 450 LYS LYS A . n 
A 1 78  SER 78  451 451 SER SER A . n 
A 1 79  PRO 79  452 452 PRO PRO A . n 
A 1 80  LEU 80  453 453 LEU LEU A . n 
A 1 81  LEU 81  454 454 LEU LEU A . n 
A 1 82  SER 82  455 455 SER SER A . n 
A 1 83  LEU 83  456 456 LEU LEU A . n 
A 1 84  GLU 84  457 457 GLU GLU A . n 
A 1 85  TRP 85  458 458 TRP TRP A . n 
A 1 86  ALA 86  459 459 ALA ALA A . n 
A 1 87  THR 87  460 460 THR THR A . n 
A 1 88  LYS 88  461 461 LYS LYS A . n 
A 1 89  ARG 89  462 462 ARG ARG A . n 
A 1 90  ASP 90  463 463 ASP ASP A . n 
A 1 91  ARG 91  464 464 ARG ARG A . n 
A 1 92  LEU 92  465 465 LEU LEU A . n 
A 1 93  LEU 93  466 466 LEU LEU A . n 
A 1 94  LEU 94  467 467 LEU LEU A . n 
A 1 95  LEU 95  468 468 LEU LEU A . n 
A 1 96  GLY 96  469 469 GLY GLY A . n 
A 1 97  SER 97  470 470 SER SER A . n 
A 1 98  GLY 98  471 471 GLY GLY A . n 
A 1 99  VAL 99  472 472 VAL VAL A . n 
A 1 100 GLY 100 473 473 GLY GLY A . n 
A 1 101 THR 101 474 474 THR THR A . n 
A 1 102 VAL 102 475 475 VAL VAL A . n 
A 1 103 ARG 103 476 476 ARG ARG A . n 
A 1 104 LEU 104 477 477 LEU LEU A . n 
A 1 105 TYR 105 478 478 TYR TYR A . n 
A 1 106 ASP 106 479 479 ASP ASP A . n 
A 1 107 THR 107 480 480 THR THR A . n 
A 1 108 GLU 108 481 481 GLU GLU A . n 
A 1 109 ALA 109 482 482 ALA ALA A . n 
A 1 110 LYS 110 483 483 LYS LYS A . n 
A 1 111 LYS 111 484 484 LYS LYS A . n 
A 1 112 ASN 112 485 485 ASN ASN A . n 
A 1 113 LEU 113 486 486 LEU LEU A . n 
A 1 114 CYS 114 487 487 CYS CYS A . n 
A 1 115 GLU 115 488 488 GLU GLU A . n 
A 1 116 ILE 116 489 489 ILE ILE A . n 
A 1 117 ASN 117 490 490 ASN ASN A . n 
A 1 118 ILE 118 491 491 ILE ILE A . n 
A 1 119 ASN 119 492 492 ASN ASN A . n 
A 1 120 ASP 120 493 493 ASP ASP A . n 
A 1 121 ASN 121 494 494 ASN ASN A . n 
A 1 122 MET 122 495 495 MET MET A . n 
A 1 123 PRO 123 496 496 PRO PRO A . n 
A 1 124 ARG 124 497 497 ARG ARG A . n 
A 1 125 ILE 125 498 498 ILE ILE A . n 
A 1 126 LEU 126 499 499 LEU LEU A . n 
A 1 127 SER 127 500 500 SER SER A . n 
A 1 128 LEU 128 501 501 LEU LEU A . n 
A 1 129 ALA 129 502 502 ALA ALA A . n 
A 1 130 CYS 130 503 503 CYS CYS A . n 
A 1 131 SER 131 504 504 SER SER A . n 
A 1 132 PRO 132 505 505 PRO PRO A . n 
A 1 133 ASN 133 506 506 ASN ASN A . n 
A 1 134 GLY 134 507 507 GLY GLY A . n 
A 1 135 ALA 135 508 508 ALA ALA A . n 
A 1 136 SER 136 509 509 SER SER A . n 
A 1 137 PHE 137 510 510 PHE PHE A . n 
A 1 138 VAL 138 511 511 VAL VAL A . n 
A 1 139 CYS 139 512 512 CYS CYS A . n 
A 1 140 SER 140 513 513 SER SER A . n 
A 1 141 ALA 141 514 514 ALA ALA A . n 
A 1 142 ALA 142 515 515 ALA ALA A . n 
A 1 143 ALA 143 516 516 ALA ALA A . n 
A 1 144 PRO 144 517 517 PRO PRO A . n 
A 1 145 SER 145 518 518 SER SER A . n 
A 1 146 LEU 146 519 519 LEU LEU A . n 
A 1 147 THR 147 520 520 THR THR A . n 
A 1 148 SER 148 521 ?   ?   ?   A . n 
A 1 149 GLN 149 522 ?   ?   ?   A . n 
A 1 150 VAL 150 523 ?   ?   ?   A . n 
A 1 151 ASP 151 524 ?   ?   ?   A . n 
A 1 152 PHE 152 525 ?   ?   ?   A . n 
A 1 153 SER 153 526 ?   ?   ?   A . n 
A 1 154 ALA 154 527 ?   ?   ?   A . n 
A 1 155 PRO 155 528 ?   ?   ?   A . n 
A 1 156 ASP 156 529 ?   ?   ?   A . n 
A 1 157 ILE 157 530 ?   ?   ?   A . n 
A 1 158 GLY 158 531 ?   ?   ?   A . n 
A 1 159 SER 159 532 ?   ?   ?   A . n 
A 1 160 LYS 160 533 ?   ?   ?   A . n 
A 1 161 GLY 161 534 ?   ?   ?   A . n 
A 1 162 MET 162 535 535 MET MET A . n 
A 1 163 ASN 163 536 536 ASN ASN A . n 
A 1 164 GLN 164 537 537 GLN GLN A . n 
A 1 165 VAL 165 538 538 VAL VAL A . n 
A 1 166 PRO 166 539 539 PRO PRO A . n 
A 1 167 GLY 167 540 540 GLY GLY A . n 
A 1 168 ARG 168 541 541 ARG ARG A . n 
A 1 169 LEU 169 542 542 LEU LEU A . n 
A 1 170 LEU 170 543 543 LEU LEU A . n 
A 1 171 LEU 171 544 544 LEU LEU A . n 
A 1 172 TRP 172 545 545 TRP TRP A . n 
A 1 173 ASP 173 546 546 ASP ASP A . n 
A 1 174 THR 174 547 547 THR THR A . n 
A 1 175 LYS 175 548 548 LYS LYS A . n 
A 1 176 THR 176 549 549 THR THR A . n 
A 1 177 MET 177 550 550 MET MET A . n 
A 1 178 LYS 178 551 551 LYS LYS A . n 
A 1 179 GLN 179 552 552 GLN GLN A . n 
A 1 180 GLN 180 553 553 GLN GLN A . n 
A 1 181 LEU 181 554 554 LEU LEU A . n 
A 1 182 GLN 182 555 555 GLN GLN A . n 
A 1 183 PHE 183 556 556 PHE PHE A . n 
A 1 184 SER 184 557 557 SER SER A . n 
A 1 185 LEU 185 558 558 LEU LEU A . n 
A 1 186 ASP 186 559 559 ASP ASP A . n 
A 1 187 PRO 187 560 560 PRO PRO A . n 
A 1 188 GLU 188 561 561 GLU GLU A . n 
A 1 189 PRO 189 562 562 PRO PRO A . n 
A 1 190 ILE 190 563 563 ILE ILE A . n 
A 1 191 ALA 191 564 564 ALA ALA A . n 
A 1 192 ILE 192 565 565 ILE ILE A . n 
A 1 193 ASN 193 566 566 ASN ASN A . n 
A 1 194 CYS 194 567 567 CYS CYS A . n 
A 1 195 THR 195 568 568 THR THR A . n 
A 1 196 ALA 196 569 569 ALA ALA A . n 
A 1 197 PHE 197 570 570 PHE PHE A . n 
A 1 198 ASN 198 571 571 ASN ASN A . n 
A 1 199 HIS 199 572 572 HIS HIS A . n 
A 1 200 ASN 200 573 573 ASN ASN A . n 
A 1 201 GLY 201 574 574 GLY GLY A . n 
A 1 202 ASN 202 575 575 ASN ASN A . n 
A 1 203 LEU 203 576 576 LEU LEU A . n 
A 1 204 LEU 204 577 577 LEU LEU A . n 
A 1 205 VAL 205 578 578 VAL VAL A . n 
A 1 206 THR 206 579 579 THR THR A . n 
A 1 207 GLY 207 580 580 GLY GLY A . n 
A 1 208 ALA 208 581 581 ALA ALA A . n 
A 1 209 ALA 209 582 582 ALA ALA A . n 
A 1 210 ASP 210 583 583 ASP ASP A . n 
A 1 211 GLY 211 584 584 GLY GLY A . n 
A 1 212 VAL 212 585 585 VAL VAL A . n 
A 1 213 ILE 213 586 586 ILE ILE A . n 
A 1 214 ARG 214 587 587 ARG ARG A . n 
A 1 215 LEU 215 588 588 LEU LEU A . n 
A 1 216 PHE 216 589 589 PHE PHE A . n 
A 1 217 ASP 217 590 590 ASP ASP A . n 
A 1 218 MET 218 591 591 MET MET A . n 
A 1 219 GLN 219 592 592 GLN GLN A . n 
A 1 220 GLN 220 593 593 GLN GLN A . n 
A 1 221 HIS 221 594 594 HIS HIS A . n 
A 1 222 GLU 222 595 595 GLU GLU A . n 
A 1 223 CYS 223 596 596 CYS CYS A . n 
A 1 224 ALA 224 597 597 ALA ALA A . n 
A 1 225 MET 225 598 598 MET MET A . n 
A 1 226 SER 226 599 599 SER SER A . n 
A 1 227 TRP 227 600 600 TRP TRP A . n 
A 1 228 ARG 228 601 601 ARG ARG A . n 
A 1 229 ALA 229 602 602 ALA ALA A . n 
A 1 230 HIS 230 603 603 HIS HIS A . n 
A 1 231 TYR 231 604 604 TYR TYR A . n 
A 1 232 GLY 232 605 605 GLY GLY A . n 
A 1 233 GLU 233 606 606 GLU GLU A . n 
A 1 234 VAL 234 607 607 VAL VAL A . n 
A 1 235 TYR 235 608 608 TYR TYR A . n 
A 1 236 SER 236 609 609 SER SER A . n 
A 1 237 VAL 237 610 610 VAL VAL A . n 
A 1 238 GLU 238 611 611 GLU GLU A . n 
A 1 239 PHE 239 612 612 PHE PHE A . n 
A 1 240 SER 240 613 613 SER SER A . n 
A 1 241 TYR 241 614 614 TYR TYR A . n 
A 1 242 ASP 242 615 615 ASP ASP A . n 
A 1 243 GLU 243 616 616 GLU GLU A . n 
A 1 244 ASN 244 617 617 ASN ASN A . n 
A 1 245 THR 245 618 618 THR THR A . n 
A 1 246 VAL 246 619 619 VAL VAL A . n 
A 1 247 TYR 247 620 620 TYR TYR A . n 
A 1 248 SER 248 621 621 SER SER A . n 
A 1 249 ILE 249 622 622 ILE ILE A . n 
A 1 250 GLY 250 623 623 GLY GLY A . n 
A 1 251 GLU 251 624 624 GLU GLU A . n 
A 1 252 ASP 252 625 625 ASP ASP A . n 
A 1 253 GLY 253 626 626 GLY GLY A . n 
A 1 254 LYS 254 627 627 LYS LYS A . n 
A 1 255 PHE 255 628 628 PHE PHE A . n 
A 1 256 ILE 256 629 629 ILE ILE A . n 
A 1 257 GLN 257 630 630 GLN GLN A . n 
A 1 258 TRP 258 631 631 TRP TRP A . n 
A 1 259 ASN 259 632 632 ASN ASN A . n 
A 1 260 ILE 260 633 633 ILE ILE A . n 
A 1 261 HIS 261 634 634 HIS HIS A . n 
A 1 262 LYS 262 635 635 LYS LYS A . n 
A 1 263 SER 263 636 636 SER SER A . n 
A 1 264 GLY 264 637 637 GLY GLY A . n 
A 1 265 LEU 265 638 638 LEU LEU A . n 
A 1 266 LYS 266 639 639 LYS LYS A . n 
A 1 267 VAL 267 640 640 VAL VAL A . n 
A 1 268 SER 268 641 641 SER SER A . n 
A 1 269 GLU 269 642 642 GLU GLU A . n 
A 1 270 TYR 270 643 643 TYR TYR A . n 
A 1 271 SER 271 644 644 SER SER A . n 
A 1 272 LEU 272 645 645 LEU LEU A . n 
A 1 273 PRO 273 646 646 PRO PRO A . n 
A 1 274 SER 274 647 647 SER SER A . n 
A 1 275 ASP 275 648 648 ASP ASP A . n 
A 1 276 ALA 276 649 649 ALA ALA A . n 
A 1 277 THR 277 650 650 THR THR A . n 
A 1 278 GLY 278 651 651 GLY GLY A . n 
A 1 279 PRO 279 652 652 PRO PRO A . n 
A 1 280 PHE 280 653 653 PHE PHE A . n 
A 1 281 VAL 281 654 654 VAL VAL A . n 
A 1 282 LEU 282 655 655 LEU LEU A . n 
A 1 283 SER 283 656 656 SER SER A . n 
A 1 284 GLY 284 657 ?   ?   ?   A . n 
A 1 285 TYR 285 658 658 TYR TYR A . n 
A 1 286 SER 286 659 659 SER SER A . n 
A 1 287 GLY 287 660 660 GLY GLY A . n 
A 1 288 TYR 288 661 661 TYR TYR A . n 
A 1 289 LYS 289 662 662 LYS LYS A . n 
A 1 290 GLN 290 663 663 GLN GLN A . n 
A 1 291 VAL 291 664 664 VAL VAL A . n 
A 1 292 GLN 292 665 665 GLN GLN A . n 
A 1 293 VAL 293 666 666 VAL VAL A . n 
A 1 294 PRO 294 667 667 PRO PRO A . n 
A 1 295 ARG 295 668 668 ARG ARG A . n 
A 1 296 GLY 296 669 669 GLY GLY A . n 
A 1 297 ARG 297 670 670 ARG ARG A . n 
A 1 298 LEU 298 671 671 LEU LEU A . n 
A 1 299 PHE 299 672 672 PHE PHE A . n 
A 1 300 ALA 300 673 673 ALA ALA A . n 
A 1 301 PHE 301 674 674 PHE PHE A . n 
A 1 302 ASP 302 675 675 ASP ASP A . n 
A 1 303 SER 303 676 676 SER SER A . n 
A 1 304 GLU 304 677 677 GLU GLU A . n 
A 1 305 GLY 305 678 678 GLY GLY A . n 
A 1 306 ASN 306 679 679 ASN ASN A . n 
A 1 307 TYR 307 680 680 TYR TYR A . n 
A 1 308 MET 308 681 681 MET MET A . n 
A 1 309 LEU 309 682 682 LEU LEU A . n 
A 1 310 THR 310 683 683 THR THR A . n 
A 1 311 CYS 311 684 684 CYS CYS A . n 
A 1 312 SER 312 685 685 SER SER A . n 
A 1 313 ALA 313 686 686 ALA ALA A . n 
A 1 314 THR 314 687 687 THR THR A . n 
A 1 315 GLY 315 688 688 GLY GLY A . n 
A 1 316 GLY 316 689 689 GLY GLY A . n 
A 1 317 VAL 317 690 690 VAL VAL A . n 
A 1 318 ILE 318 691 691 ILE ILE A . n 
A 1 319 TYR 319 692 692 TYR TYR A . n 
A 1 320 LYS 320 693 693 LYS LYS A . n 
A 1 321 LEU 321 694 694 LEU LEU A . n 
A 1 322 GLY 322 695 695 GLY GLY A . n 
A 1 323 GLY 323 696 696 GLY GLY A . n 
A 1 324 ASP 324 697 697 ASP ASP A . n 
A 1 325 GLU 325 698 698 GLU GLU A . n 
A 1 326 LYS 326 699 699 LYS LYS A . n 
A 1 327 VAL 327 700 700 VAL VAL A . n 
A 1 328 LEU 328 701 701 LEU LEU A . n 
A 1 329 GLU 329 702 702 GLU GLU A . n 
A 1 330 SER 330 703 703 SER SER A . n 
A 1 331 CYS 331 704 704 CYS CYS A . n 
A 1 332 LEU 332 705 705 LEU LEU A . n 
A 1 333 SER 333 706 706 SER SER A . n 
A 1 334 LEU 334 707 707 LEU LEU A . n 
A 1 335 GLY 335 708 708 GLY GLY A . n 
A 1 336 GLY 336 709 709 GLY GLY A . n 
A 1 337 HIS 337 710 710 HIS HIS A . n 
A 1 338 ARG 338 711 711 ARG ARG A . n 
A 1 339 ALA 339 712 712 ALA ALA A . n 
A 1 340 PRO 340 713 713 PRO PRO A . n 
A 1 341 VAL 341 714 714 VAL VAL A . n 
A 1 342 VAL 342 715 715 VAL VAL A . n 
A 1 343 THR 343 716 716 THR THR A . n 
A 1 344 VAL 344 717 717 VAL VAL A . n 
A 1 345 ASP 345 718 718 ASP ASP A . n 
A 1 346 TRP 346 719 719 TRP TRP A . n 
A 1 347 SER 347 720 720 SER SER A . n 
A 1 348 THR 348 721 721 THR THR A . n 
A 1 349 ALA 349 722 722 ALA ALA A . n 
A 1 350 MET 350 723 723 MET MET A . n 
A 1 351 ASP 351 724 724 ASP ASP A . n 
A 1 352 CYS 352 725 725 CYS CYS A . n 
A 1 353 GLY 353 726 726 GLY GLY A . n 
A 1 354 THR 354 727 727 THR THR A . n 
A 1 355 CYS 355 728 728 CYS CYS A . n 
A 1 356 LEU 356 729 729 LEU LEU A . n 
A 1 357 THR 357 730 730 THR THR A . n 
A 1 358 ALA 358 731 731 ALA ALA A . n 
A 1 359 SER 359 732 732 SER SER A . n 
A 1 360 MET 360 733 733 MET MET A . n 
A 1 361 ASP 361 734 734 ASP ASP A . n 
A 1 362 GLY 362 735 735 GLY GLY A . n 
A 1 363 LYS 363 736 736 LYS LYS A . n 
A 1 364 ILE 364 737 737 ILE ILE A . n 
A 1 365 LYS 365 738 738 LYS LYS A . n 
A 1 366 LEU 366 739 739 LEU LEU A . n 
A 1 367 THR 367 740 740 THR THR A . n 
A 1 368 THR 368 741 741 THR THR A . n 
A 1 369 LEU 369 742 742 LEU LEU A . n 
A 1 370 LEU 370 743 743 LEU LEU A . n 
A 1 371 ALA 371 744 744 ALA ALA A . n 
A 1 372 HIS 372 745 745 HIS HIS A . n 
A 1 373 LYS 373 746 ?   ?   ?   A . n 
A 1 374 ALA 374 747 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BIW 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BIW 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1BIW 1  801 801  A1BIW LIG A . 
C 3 UNX   1  802 1000 UNX   UNX A . 
D 4 HOH   1  901 129  HOH   HOH A . 
D 4 HOH   2  902 124  HOH   HOH A . 
D 4 HOH   3  903 110  HOH   HOH A . 
D 4 HOH   4  904 43   HOH   HOH A . 
D 4 HOH   5  905 118  HOH   HOH A . 
D 4 HOH   6  906 125  HOH   HOH A . 
D 4 HOH   7  907 91   HOH   HOH A . 
D 4 HOH   8  908 15   HOH   HOH A . 
D 4 HOH   9  909 19   HOH   HOH A . 
D 4 HOH   10 910 93   HOH   HOH A . 
D 4 HOH   11 911 44   HOH   HOH A . 
D 4 HOH   12 912 1    HOH   HOH A . 
D 4 HOH   13 913 127  HOH   HOH A . 
D 4 HOH   14 914 112  HOH   HOH A . 
D 4 HOH   15 915 107  HOH   HOH A . 
D 4 HOH   16 916 103  HOH   HOH A . 
D 4 HOH   17 917 115  HOH   HOH A . 
D 4 HOH   18 918 45   HOH   HOH A . 
D 4 HOH   19 919 105  HOH   HOH A . 
D 4 HOH   20 920 72   HOH   HOH A . 
D 4 HOH   21 921 120  HOH   HOH A . 
D 4 HOH   22 922 9    HOH   HOH A . 
D 4 HOH   23 923 96   HOH   HOH A . 
D 4 HOH   24 924 97   HOH   HOH A . 
D 4 HOH   25 925 26   HOH   HOH A . 
D 4 HOH   26 926 80   HOH   HOH A . 
D 4 HOH   27 927 70   HOH   HOH A . 
D 4 HOH   28 928 56   HOH   HOH A . 
D 4 HOH   29 929 116  HOH   HOH A . 
D 4 HOH   30 930 71   HOH   HOH A . 
D 4 HOH   31 931 42   HOH   HOH A . 
D 4 HOH   32 932 83   HOH   HOH A . 
D 4 HOH   33 933 85   HOH   HOH A . 
D 4 HOH   34 934 117  HOH   HOH A . 
D 4 HOH   35 935 64   HOH   HOH A . 
D 4 HOH   36 936 69   HOH   HOH A . 
D 4 HOH   37 937 78   HOH   HOH A . 
D 4 HOH   38 938 3    HOH   HOH A . 
D 4 HOH   39 939 8    HOH   HOH A . 
D 4 HOH   40 940 126  HOH   HOH A . 
D 4 HOH   41 941 67   HOH   HOH A . 
D 4 HOH   42 942 50   HOH   HOH A . 
D 4 HOH   43 943 11   HOH   HOH A . 
D 4 HOH   44 944 76   HOH   HOH A . 
D 4 HOH   45 945 16   HOH   HOH A . 
D 4 HOH   46 946 109  HOH   HOH A . 
D 4 HOH   47 947 73   HOH   HOH A . 
D 4 HOH   48 948 40   HOH   HOH A . 
D 4 HOH   49 949 87   HOH   HOH A . 
D 4 HOH   50 950 53   HOH   HOH A . 
D 4 HOH   51 951 60   HOH   HOH A . 
D 4 HOH   52 952 61   HOH   HOH A . 
D 4 HOH   53 953 39   HOH   HOH A . 
D 4 HOH   54 954 22   HOH   HOH A . 
D 4 HOH   55 955 51   HOH   HOH A . 
D 4 HOH   56 956 17   HOH   HOH A . 
D 4 HOH   57 957 21   HOH   HOH A . 
D 4 HOH   58 958 113  HOH   HOH A . 
D 4 HOH   59 959 36   HOH   HOH A . 
D 4 HOH   60 960 65   HOH   HOH A . 
D 4 HOH   61 961 63   HOH   HOH A . 
D 4 HOH   62 962 86   HOH   HOH A . 
D 4 HOH   63 963 99   HOH   HOH A . 
D 4 HOH   64 964 108  HOH   HOH A . 
D 4 HOH   65 965 100  HOH   HOH A . 
D 4 HOH   66 966 28   HOH   HOH A . 
D 4 HOH   67 967 5    HOH   HOH A . 
D 4 HOH   68 968 38   HOH   HOH A . 
D 4 HOH   69 969 123  HOH   HOH A . 
D 4 HOH   70 970 82   HOH   HOH A . 
D 4 HOH   71 971 122  HOH   HOH A . 
D 4 HOH   72 972 77   HOH   HOH A . 
D 4 HOH   73 973 7    HOH   HOH A . 
D 4 HOH   74 974 98   HOH   HOH A . 
D 4 HOH   75 975 111  HOH   HOH A . 
D 4 HOH   76 976 88   HOH   HOH A . 
D 4 HOH   77 977 62   HOH   HOH A . 
D 4 HOH   78 978 66   HOH   HOH A . 
D 4 HOH   79 979 128  HOH   HOH A . 
D 4 HOH   80 980 13   HOH   HOH A . 
D 4 HOH   81 981 47   HOH   HOH A . 
D 4 HOH   82 982 46   HOH   HOH A . 
D 4 HOH   83 983 106  HOH   HOH A . 
D 4 HOH   84 984 79   HOH   HOH A . 
D 4 HOH   85 985 114  HOH   HOH A . 
D 4 HOH   86 986 121  HOH   HOH A . 
D 4 HOH   87 987 29   HOH   HOH A . 
D 4 HOH   88 988 57   HOH   HOH A . 
D 4 HOH   89 989 74   HOH   HOH A . 
D 4 HOH   90 990 119  HOH   HOH A . 
D 4 HOH   91 991 81   HOH   HOH A . 
D 4 HOH   92 992 48   HOH   HOH A . 
D 4 HOH   93 993 102  HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLN 394 ? CG  ? A GLN 21  CG  
2  1 Y 1 A GLN 394 ? CD  ? A GLN 21  CD  
3  1 Y 1 A GLN 394 ? OE1 ? A GLN 21  OE1 
4  1 Y 1 A GLN 394 ? NE2 ? A GLN 21  NE2 
5  1 Y 1 A ILE 397 ? CD1 ? A ILE 24  CD1 
6  1 Y 1 A ILE 432 ? CD1 ? A ILE 59  CD1 
7  1 Y 1 A ILE 448 ? CD1 ? A ILE 75  CD1 
8  1 Y 1 A LYS 450 ? CG  ? A LYS 77  CG  
9  1 Y 1 A LYS 450 ? CD  ? A LYS 77  CD  
10 1 Y 1 A LYS 450 ? CE  ? A LYS 77  CE  
11 1 Y 1 A LYS 450 ? NZ  ? A LYS 77  NZ  
12 1 Y 1 A ARG 464 ? CG  ? A ARG 91  CG  
13 1 Y 1 A ARG 464 ? CD  ? A ARG 91  CD  
14 1 Y 1 A ARG 464 ? NE  ? A ARG 91  NE  
15 1 Y 1 A ARG 464 ? CZ  ? A ARG 91  CZ  
16 1 Y 1 A ARG 464 ? NH1 ? A ARG 91  NH1 
17 1 Y 1 A ARG 464 ? NH2 ? A ARG 91  NH2 
18 1 Y 1 A GLU 481 ? CD  ? A GLU 108 CD  
19 1 Y 1 A GLU 481 ? OE1 ? A GLU 108 OE1 
20 1 Y 1 A GLU 481 ? OE2 ? A GLU 108 OE2 
21 1 Y 1 A LYS 484 ? CE  ? A LYS 111 CE  
22 1 Y 1 A LYS 484 ? NZ  ? A LYS 111 NZ  
23 1 Y 1 A ASN 492 ? CG  ? A ASN 119 CG  
24 1 Y 1 A ASN 492 ? OD1 ? A ASN 119 OD1 
25 1 Y 1 A ASN 492 ? ND2 ? A ASN 119 ND2 
26 1 Y 1 A SER 518 ? OG  ? A SER 145 OG  
27 1 Y 1 A THR 520 ? OG1 ? A THR 147 OG1 
28 1 Y 1 A THR 520 ? CG2 ? A THR 147 CG2 
29 1 Y 1 A LYS 548 ? CG  ? A LYS 175 CG  
30 1 Y 1 A LYS 548 ? CD  ? A LYS 175 CD  
31 1 Y 1 A LYS 548 ? CE  ? A LYS 175 CE  
32 1 Y 1 A LYS 548 ? NZ  ? A LYS 175 NZ  
33 1 Y 1 A LYS 551 ? CD  ? A LYS 178 CD  
34 1 Y 1 A LYS 551 ? CE  ? A LYS 178 CE  
35 1 Y 1 A LYS 551 ? NZ  ? A LYS 178 NZ  
36 1 Y 1 A LYS 627 ? NZ  ? A LYS 254 NZ  
37 1 Y 1 A TYR 658 ? CG  ? A TYR 285 CG  
38 1 Y 1 A TYR 658 ? CD1 ? A TYR 285 CD1 
39 1 Y 1 A TYR 658 ? CD2 ? A TYR 285 CD2 
40 1 Y 1 A TYR 658 ? CE1 ? A TYR 285 CE1 
41 1 Y 1 A TYR 658 ? CE2 ? A TYR 285 CE2 
42 1 Y 1 A TYR 658 ? CZ  ? A TYR 285 CZ  
43 1 Y 1 A TYR 658 ? OH  ? A TYR 285 OH  
44 1 Y 1 A SER 659 ? OG  ? A SER 286 OG  
45 1 Y 1 A LYS 693 ? CD  ? A LYS 320 CD  
46 1 Y 1 A LYS 693 ? CE  ? A LYS 320 CE  
47 1 Y 1 A LYS 693 ? NZ  ? A LYS 320 NZ  
48 1 Y 1 A ASP 697 ? CG  ? A ASP 324 CG  
49 1 Y 1 A ASP 697 ? OD1 ? A ASP 324 OD1 
50 1 Y 1 A ASP 697 ? OD2 ? A ASP 324 OD2 
51 1 Y 1 A GLU 698 ? CG  ? A GLU 325 CG  
52 1 Y 1 A GLU 698 ? CD  ? A GLU 325 CD  
53 1 Y 1 A GLU 698 ? OE1 ? A GLU 325 OE1 
54 1 Y 1 A GLU 698 ? OE2 ? A GLU 325 OE2 
55 1 Y 1 A LYS 699 ? CG  ? A LYS 326 CG  
56 1 Y 1 A LYS 699 ? CD  ? A LYS 326 CD  
57 1 Y 1 A LYS 699 ? CE  ? A LYS 326 CE  
58 1 Y 1 A LYS 699 ? NZ  ? A LYS 326 NZ  
59 1 Y 1 A VAL 700 ? CG1 ? A VAL 327 CG1 
60 1 Y 1 A VAL 700 ? CG2 ? A VAL 327 CG2 
61 1 Y 1 A GLU 702 ? CG  ? A GLU 329 CG  
62 1 Y 1 A GLU 702 ? CD  ? A GLU 329 CD  
63 1 Y 1 A GLU 702 ? OE1 ? A GLU 329 OE1 
64 1 Y 1 A GLU 702 ? OE2 ? A GLU 329 OE2 
65 1 Y 1 A ARG 711 ? CD  ? A ARG 338 CD  
66 1 Y 1 A ARG 711 ? NE  ? A ARG 338 NE  
67 1 Y 1 A ARG 711 ? CZ  ? A ARG 338 CZ  
68 1 Y 1 A ARG 711 ? NH1 ? A ARG 338 NH1 
69 1 Y 1 A ARG 711 ? NH2 ? A ARG 338 NH2 
70 1 Y 1 A ASP 724 ? CG  ? A ASP 351 CG  
71 1 Y 1 A ASP 724 ? OD1 ? A ASP 351 OD1 
72 1 Y 1 A ASP 724 ? OD2 ? A ASP 351 OD2 
73 1 Y 1 A LEU 743 ? CG  ? A LEU 370 CG  
74 1 Y 1 A LEU 743 ? CD1 ? A LEU 370 CD1 
75 1 Y 1 A LEU 743 ? CD2 ? A LEU 370 CD2 
76 1 Y 1 A HIS 745 ? CG  ? A HIS 372 CG  
77 1 Y 1 A HIS 745 ? ND1 ? A HIS 372 ND1 
78 1 Y 1 A HIS 745 ? CD2 ? A HIS 372 CD2 
79 1 Y 1 A HIS 745 ? CE1 ? A HIS 372 CE1 
80 1 Y 1 A HIS 745 ? NE2 ? A HIS 372 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement     ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0425 1 
? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .        2 
? phasing        ? ? ? ? ? ? ? ? ? ? ? PHASES   ? ? ? .        3 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EJP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     77.613 
_cell.length_a_esd                 ? 
_cell.length_b                     132.547 
_cell.length_b_esd                 ? 
_cell.length_c                     119.797 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EJP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EJP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.75 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          67.21 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '10% w/v PEG 8000, 20% v/v ethylene glycol, 0.02M of each alcohol, 0.1M MOPS/HEPES-Na pH7.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 2M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-11-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97741 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97741 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.1 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EJP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.22 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     30949 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.828 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.065 
_reflns.pdbx_Rpim_I_all                                0.019 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   1.000 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.062 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.22 2.26  ? ? ? ? ? ? 1534 ? ? ? ? ? ? ? ? ? ? ? 10.8 0.977 ? ? 0.949 0.286 ? 1  1 0.802 0.943 ? 100.0 ? 0.904 ? ? ? ? ? ? ? ? ? 
2.26 2.30  ? ? ? ? ? ? 1499 ? ? ? ? ? ? ? ? ? ? ? 11.0 0.975 ? ? 0.917 0.273 ? 2  1 0.846 0.957 ? 100.0 ? 0.874 ? ? ? ? ? ? ? ? ? 
2.30 2.34  ? ? ? ? ? ? 1528 ? ? ? ? ? ? ? ? ? ? ? 11.1 0.937 ? ? 0.808 0.239 ? 3  1 0.871 0.965 ? 100.0 ? 0.771 ? ? ? ? ? ? ? ? ? 
2.34 2.39  ? ? ? ? ? ? 1533 ? ? ? ? ? ? ? ? ? ? ? 11.1 0.919 ? ? 0.701 0.208 ? 4  1 0.910 0.976 ? 100.0 ? 0.669 ? ? ? ? ? ? ? ? ? 
2.39 2.44  ? ? ? ? ? ? 1518 ? ? ? ? ? ? ? ? ? ? ? 11.1 0.907 ? ? 0.589 0.175 ? 5  1 0.927 0.981 ? 100.0 ? 0.562 ? ? ? ? ? ? ? ? ? 
2.44 2.50  ? ? ? ? ? ? 1544 ? ? ? ? ? ? ? ? ? ? ? 11.0 0.913 ? ? 0.505 0.150 ? 6  1 0.944 0.986 ? 100.0 ? 0.482 ? ? ? ? ? ? ? ? ? 
2.50 2.56  ? ? ? ? ? ? 1522 ? ? ? ? ? ? ? ? ? ? ? 11.0 0.883 ? ? 0.407 0.121 ? 7  1 0.960 0.990 ? 100.0 ? 0.388 ? ? ? ? ? ? ? ? ? 
2.56 2.63  ? ? ? ? ? ? 1533 ? ? ? ? ? ? ? ? ? ? ? 10.9 0.852 ? ? 0.336 0.101 ? 8  1 0.973 0.993 ? 100.0 ? 0.321 ? ? ? ? ? ? ? ? ? 
2.63 2.71  ? ? ? ? ? ? 1517 ? ? ? ? ? ? ? ? ? ? ? 10.6 0.845 ? ? 0.262 0.079 ? 9  1 0.981 0.995 ? 100.0 ? 0.249 ? ? ? ? ? ? ? ? ? 
2.71 2.80  ? ? ? ? ? ? 1562 ? ? ? ? ? ? ? ? ? ? ? 9.8  0.883 ? ? 0.211 0.067 ? 10 1 0.987 0.997 ? 100.0 ? 0.200 ? ? ? ? ? ? ? ? ? 
2.80 2.90  ? ? ? ? ? ? 1526 ? ? ? ? ? ? ? ? ? ? ? 9.9  0.851 ? ? 0.164 0.052 ? 11 1 0.992 0.998 ? 100.0 ? 0.155 ? ? ? ? ? ? ? ? ? 
2.90 3.01  ? ? ? ? ? ? 1528 ? ? ? ? ? ? ? ? ? ? ? 10.3 0.832 ? ? 0.140 0.043 ? 12 1 0.994 0.998 ? 100.0 ? 0.133 ? ? ? ? ? ? ? ? ? 
3.01 3.15  ? ? ? ? ? ? 1555 ? ? ? ? ? ? ? ? ? ? ? 10.4 0.745 ? ? 0.099 0.030 ? 13 1 0.997 0.999 ? 100.0 ? 0.094 ? ? ? ? ? ? ? ? ? 
3.15 3.32  ? ? ? ? ? ? 1549 ? ? ? ? ? ? ? ? ? ? ? 11.6 0.663 ? ? 0.076 0.022 ? 14 1 0.998 1.000 ? 100.0 ? 0.073 ? ? ? ? ? ? ? ? ? 
3.32 3.52  ? ? ? ? ? ? 1546 ? ? ? ? ? ? ? ? ? ? ? 11.5 0.544 ? ? 0.054 0.016 ? 15 1 0.999 1.000 ? 100.0 ? 0.051 ? ? ? ? ? ? ? ? ? 
3.52 3.80  ? ? ? ? ? ? 1553 ? ? ? ? ? ? ? ? ? ? ? 11.5 0.674 ? ? 0.045 0.013 ? 16 1 0.999 1.000 ? 100.0 ? 0.043 ? ? ? ? ? ? ? ? ? 
3.80 4.18  ? ? ? ? ? ? 1565 ? ? ? ? ? ? ? ? ? ? ? 11.1 0.854 ? ? 0.035 0.010 ? 17 1 1.000 1.000 ? 100.0 ? 0.034 ? ? ? ? ? ? ? ? ? 
4.18 4.78  ? ? ? ? ? ? 1577 ? ? ? ? ? ? ? ? ? ? ? 10.5 0.863 ? ? 0.028 0.008 ? 18 1 1.000 1.000 ? 100.0 ? 0.026 ? ? ? ? ? ? ? ? ? 
4.78 6.02  ? ? ? ? ? ? 1586 ? ? ? ? ? ? ? ? ? ? ? 9.7  0.776 ? ? 0.027 0.009 ? 19 1 1.000 1.000 ? 100.0 ? 0.026 ? ? ? ? ? ? ? ? ? 
6.02 50.00 ? ? ? ? ? ? 1674 ? ? ? ? ? ? ? ? ? ? ? 11.1 0.714 ? ? 0.024 0.007 ? 20 1 0.999 1.000 ? 100.0 ? 0.022 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            1.19 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            -0.93 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -0.26 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               44.285 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.950 
_refine.correlation_coeff_Fo_to_Fc_free          0.927 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EJP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.22 
_refine.ls_d_res_low                             44.69 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29329 
_refine.ls_number_reflns_R_free                  1573 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.77 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20470 
_refine.ls_R_factor_R_free                       0.24497 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20262 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.174 
_refine.pdbx_overall_ESU_R_Free                  0.167 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.871 
_refine.overall_SU_ML                            0.119 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.22 
_refine_hist.d_res_low                        44.69 
_refine_hist.number_atoms_solvent             93 
_refine_hist.number_atoms_total               2629 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2535 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005  0.012  2648 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2406 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.342  1.794  3609 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.471  1.742  5525 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.494  5.000  344  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 7.567  5.000  14   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.382 10.000 399  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.064  0.200  406  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  3221 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  605  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 3.578  4.687  1370 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.572  4.687  1370 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 5.486  8.387  1716 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.485  8.391  1717 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 3.880  4.944  1278 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.879  4.945  1279 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 6.006  8.956  1894 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 8.498  42.03  2683 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 8.506  42.03  2672 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.22 
_refine_ls_shell.d_res_low                        2.276 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             108 
_refine_ls_shell.number_reflns_R_work             2086 
_refine_ls_shell.percent_reflns_obs               98.12 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.294 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.313 
# 
_struct.entry_id                     9EJP 
_struct.title                        'Crystal structure of WDR91 in complex with XS838489' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EJP 
_struct_keywords.text            'WD-repeat, WDR, WDR91, protein transport, ligand, SGC, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    WDR91_HUMAN 
_struct_ref.pdbx_db_accession          A4D1P6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;PEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSG
VGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMK
QQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQW
NIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHR
APVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA
;
_struct_ref.pdbx_align_begin           392 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EJP 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 19 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 374 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A4D1P6 
_struct_ref_seq.db_align_beg                  392 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  747 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       392 
_struct_ref_seq.pdbx_auth_seq_align_end       747 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EJP MET A 1  ? UNP A4D1P6 ? ? 'expression tag' 374 1  
1 9EJP HIS A 2  ? UNP A4D1P6 ? ? 'expression tag' 375 2  
1 9EJP HIS A 3  ? UNP A4D1P6 ? ? 'expression tag' 376 3  
1 9EJP HIS A 4  ? UNP A4D1P6 ? ? 'expression tag' 377 4  
1 9EJP HIS A 5  ? UNP A4D1P6 ? ? 'expression tag' 378 5  
1 9EJP HIS A 6  ? UNP A4D1P6 ? ? 'expression tag' 379 6  
1 9EJP HIS A 7  ? UNP A4D1P6 ? ? 'expression tag' 380 7  
1 9EJP SER A 8  ? UNP A4D1P6 ? ? 'expression tag' 381 8  
1 9EJP SER A 9  ? UNP A4D1P6 ? ? 'expression tag' 382 9  
1 9EJP GLY A 10 ? UNP A4D1P6 ? ? 'expression tag' 383 10 
1 9EJP ARG A 11 ? UNP A4D1P6 ? ? 'expression tag' 384 11 
1 9EJP GLU A 12 ? UNP A4D1P6 ? ? 'expression tag' 385 12 
1 9EJP ASN A 13 ? UNP A4D1P6 ? ? 'expression tag' 386 13 
1 9EJP LEU A 14 ? UNP A4D1P6 ? ? 'expression tag' 387 14 
1 9EJP TYR A 15 ? UNP A4D1P6 ? ? 'expression tag' 388 15 
1 9EJP PHE A 16 ? UNP A4D1P6 ? ? 'expression tag' 389 16 
1 9EJP GLN A 17 ? UNP A4D1P6 ? ? 'expression tag' 390 17 
1 9EJP GLY A 18 ? UNP A4D1P6 ? ? 'expression tag' 391 18 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_struct_conf.conf_type_id            HELX_P 
_struct_conf.id                      HELX_P1 
_struct_conf.pdbx_PDB_helix_id       AA1 
_struct_conf.beg_label_comp_id       PRO 
_struct_conf.beg_label_asym_id       A 
_struct_conf.beg_label_seq_id        273 
_struct_conf.pdbx_beg_PDB_ins_code   ? 
_struct_conf.end_label_comp_id       THR 
_struct_conf.end_label_asym_id       A 
_struct_conf.end_label_seq_id        277 
_struct_conf.pdbx_end_PDB_ins_code   ? 
_struct_conf.beg_auth_comp_id        PRO 
_struct_conf.beg_auth_asym_id        A 
_struct_conf.beg_auth_seq_id         646 
_struct_conf.end_auth_comp_id        THR 
_struct_conf.end_auth_asym_id        A 
_struct_conf.end_auth_seq_id         650 
_struct_conf.pdbx_PDB_helix_class    5 
_struct_conf.details                 ? 
_struct_conf.pdbx_PDB_helix_length   5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ASN 65  A . ? ASN 438 A PRO 66  A ? PRO 439 A 1 11.85 
2 ASP 186 A . ? ASP 559 A PRO 187 A ? PRO 560 A 1 -2.84 
3 ASP 186 A . ? ASP 559 A PRO 187 A ? PRO 560 A 1 6.50  
4 GLY 278 A . ? GLY 651 A PRO 279 A ? PRO 652 A 1 6.87  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 2 ? 
AA8 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 23  ? TYR A 31  ? PHE A 396 TYR A 404 
AA1 2 ILE A 364 ? ALA A 371 ? ILE A 737 ALA A 744 
AA1 3 GLY A 353 ? SER A 359 ? GLY A 726 SER A 732 
AA1 4 VAL A 341 ? THR A 348 ? VAL A 714 THR A 721 
AA2 1 ILE A 38  ? VAL A 43  ? ILE A 411 VAL A 416 
AA2 2 ARG A 49  ? ASP A 54  ? ARG A 422 ASP A 427 
AA2 3 VAL A 58  ? SER A 63  ? VAL A 431 SER A 436 
AA2 4 GLN A 69  ? ILE A 75  ? GLN A 442 ILE A 448 
AA3 1 LEU A 80  ? TRP A 85  ? LEU A 453 TRP A 458 
AA3 2 LEU A 92  ? SER A 97  ? LEU A 465 SER A 470 
AA3 3 THR A 101 ? ASP A 106 ? THR A 474 ASP A 479 
AA3 4 LYS A 111 ? ASN A 117 ? LYS A 484 ASN A 490 
AA4 1 ARG A 124 ? CYS A 130 ? ARG A 497 CYS A 503 
AA4 2 SER A 136 ? ALA A 142 ? SER A 509 ALA A 515 
AA4 3 GLY A 167 ? ASP A 173 ? GLY A 540 ASP A 546 
AA4 4 LYS A 178 ? PHE A 183 ? LYS A 551 PHE A 556 
AA5 1 ILE A 192 ? PHE A 197 ? ILE A 565 PHE A 570 
AA5 2 LEU A 203 ? ALA A 208 ? LEU A 576 ALA A 581 
AA5 3 VAL A 212 ? ASP A 217 ? VAL A 585 ASP A 590 
AA5 4 GLU A 222 ? ARG A 228 ? GLU A 595 ARG A 601 
AA6 1 VAL A 234 ? PHE A 239 ? VAL A 607 PHE A 612 
AA6 2 THR A 245 ? GLY A 250 ? THR A 618 GLY A 623 
AA6 3 LYS A 254 ? ASN A 259 ? LYS A 627 ASN A 632 
AA6 4 LYS A 266 ? SER A 271 ? LYS A 639 SER A 644 
AA7 1 PHE A 280 ? LEU A 282 ? PHE A 653 LEU A 655 
AA7 2 GLN A 290 ? GLN A 292 ? GLN A 663 GLN A 665 
AA8 1 PHE A 299 ? PHE A 301 ? PHE A 672 PHE A 674 
AA8 2 TYR A 307 ? THR A 310 ? TYR A 680 THR A 683 
AA8 3 VAL A 317 ? LYS A 320 ? VAL A 690 LYS A 693 
AA8 4 LEU A 332 ? SER A 333 ? LEU A 705 SER A 706 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 24  ? N ILE A 397 O LEU A 370 ? O LEU A 743 
AA1 2 3 O THR A 367 ? O THR A 740 N CYS A 355 ? N CYS A 728 
AA1 3 4 O THR A 354 ? O THR A 727 N SER A 347 ? N SER A 720 
AA2 1 2 N MET A 39  ? N MET A 412 O LEU A 53  ? O LEU A 426 
AA2 2 3 N VAL A 50  ? N VAL A 423 O TRP A 62  ? O TRP A 435 
AA2 3 4 N VAL A 61  ? N VAL A 434 O LYS A 71  ? O LYS A 444 
AA3 1 2 N GLU A 84  ? N GLU A 457 O LEU A 94  ? O LEU A 467 
AA3 2 3 N LEU A 93  ? N LEU A 466 O TYR A 105 ? O TYR A 478 
AA3 3 4 N VAL A 102 ? N VAL A 475 O ILE A 116 ? O ILE A 489 
AA4 1 2 N ARG A 124 ? N ARG A 497 O ALA A 142 ? O ALA A 515 
AA4 2 3 N CYS A 139 ? N CYS A 512 O LEU A 170 ? O LEU A 543 
AA4 3 4 N LEU A 171 ? N LEU A 544 O LEU A 181 ? O LEU A 554 
AA5 1 2 N ALA A 196 ? N ALA A 569 O VAL A 205 ? O VAL A 578 
AA5 2 3 N LEU A 204 ? N LEU A 577 O PHE A 216 ? O PHE A 589 
AA5 3 4 N LEU A 215 ? N LEU A 588 O MET A 225 ? O MET A 598 
AA6 1 2 N GLU A 238 ? N GLU A 611 O TYR A 247 ? O TYR A 620 
AA6 2 3 N VAL A 246 ? N VAL A 619 O TRP A 258 ? O TRP A 631 
AA6 3 4 N GLN A 257 ? N GLN A 630 O VAL A 267 ? O VAL A 640 
AA7 1 2 N PHE A 280 ? N PHE A 653 O GLN A 292 ? O GLN A 665 
AA8 1 2 N ALA A 300 ? N ALA A 673 O LEU A 309 ? O LEU A 682 
AA8 2 3 N MET A 308 ? N MET A 681 O TYR A 319 ? O TYR A 692 
AA8 3 4 N ILE A 318 ? N ILE A 691 O LEU A 332 ? O LEU A 705 
# 
_pdbx_entry_details.entry_id                   9EJP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OG A SER 703 ? ? O   A HOH 901 ? ? 2.19 
2 1 NE A ARG 476 ? A OD1 A ASN 485 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 437 ? ? -143.49 -11.24 
2 1 ASN A 492 ? ? -68.75  81.53  
3 1 ARG A 668 ? ? -135.56 -42.82 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     670 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    A 
_pdbx_validate_planes.rmsd            0.100 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 374 ? A MET 1   
2  1 Y 1 A HIS 375 ? A HIS 2   
3  1 Y 1 A HIS 376 ? A HIS 3   
4  1 Y 1 A HIS 377 ? A HIS 4   
5  1 Y 1 A HIS 378 ? A HIS 5   
6  1 Y 1 A HIS 379 ? A HIS 6   
7  1 Y 1 A HIS 380 ? A HIS 7   
8  1 Y 1 A SER 381 ? A SER 8   
9  1 Y 1 A SER 382 ? A SER 9   
10 1 Y 1 A GLY 383 ? A GLY 10  
11 1 Y 1 A ARG 384 ? A ARG 11  
12 1 Y 1 A GLU 385 ? A GLU 12  
13 1 Y 1 A ASN 386 ? A ASN 13  
14 1 Y 1 A LEU 387 ? A LEU 14  
15 1 Y 1 A TYR 388 ? A TYR 15  
16 1 Y 1 A PHE 389 ? A PHE 16  
17 1 Y 1 A GLN 390 ? A GLN 17  
18 1 Y 1 A GLY 391 ? A GLY 18  
19 1 Y 1 A PRO 392 ? A PRO 19  
20 1 Y 1 A GLU 393 ? A GLU 20  
21 1 Y 1 A SER 521 ? A SER 148 
22 1 Y 1 A GLN 522 ? A GLN 149 
23 1 Y 1 A VAL 523 ? A VAL 150 
24 1 Y 1 A ASP 524 ? A ASP 151 
25 1 Y 1 A PHE 525 ? A PHE 152 
26 1 Y 1 A SER 526 ? A SER 153 
27 1 Y 1 A ALA 527 ? A ALA 154 
28 1 Y 1 A PRO 528 ? A PRO 155 
29 1 Y 1 A ASP 529 ? A ASP 156 
30 1 Y 1 A ILE 530 ? A ILE 157 
31 1 Y 1 A GLY 531 ? A GLY 158 
32 1 Y 1 A SER 532 ? A SER 159 
33 1 Y 1 A LYS 533 ? A LYS 160 
34 1 Y 1 A GLY 534 ? A GLY 161 
35 1 Y 1 A GLY 657 ? A GLY 284 
36 1 Y 1 A LYS 746 ? A LYS 373 
37 1 Y 1 A ALA 747 ? A ALA 374 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BIW C4   C Y N 1   
A1BIW C5   C Y N 2   
A1BIW C6   C Y N 3   
A1BIW C7   C Y N 4   
A1BIW C8   C Y N 5   
A1BIW C15  C N N 6   
A1BIW C17  C Y N 7   
A1BIW C20  C Y N 8   
A1BIW C21  C Y N 9   
A1BIW C24  C Y N 10  
A1BIW C1   C N N 11  
A1BIW C2   C N N 12  
A1BIW C3   C N R 13  
A1BIW C9   C Y N 14  
A1BIW S10  S N N 15  
A1BIW C11  C N N 16  
A1BIW O12  O N N 17  
A1BIW O13  O N N 18  
A1BIW N14  N N N 19  
A1BIW C16  C Y N 20  
A1BIW C18  C Y N 21  
A1BIW C19  C Y N 22  
A1BIW N22  N Y N 23  
A1BIW C23  C Y N 24  
A1BIW N25  N Y N 25  
A1BIW O26  O N N 26  
A1BIW O27  O N N 27  
A1BIW H1   H N N 28  
A1BIW H2   H N N 29  
A1BIW H3   H N N 30  
A1BIW H4   H N N 31  
A1BIW H5   H N N 32  
A1BIW H6   H N N 33  
A1BIW H7   H N N 34  
A1BIW H8   H N N 35  
A1BIW H9   H N N 36  
A1BIW H10  H N N 37  
A1BIW H11  H N N 38  
A1BIW H12  H N N 39  
A1BIW H13  H N N 40  
A1BIW H14  H N N 41  
A1BIW H15  H N N 42  
A1BIW H16  H N N 43  
A1BIW H17  H N N 44  
ALA   N    N N N 45  
ALA   CA   C N S 46  
ALA   C    C N N 47  
ALA   O    O N N 48  
ALA   CB   C N N 49  
ALA   OXT  O N N 50  
ALA   H    H N N 51  
ALA   H2   H N N 52  
ALA   HA   H N N 53  
ALA   HB1  H N N 54  
ALA   HB2  H N N 55  
ALA   HB3  H N N 56  
ALA   HXT  H N N 57  
ARG   N    N N N 58  
ARG   CA   C N S 59  
ARG   C    C N N 60  
ARG   O    O N N 61  
ARG   CB   C N N 62  
ARG   CG   C N N 63  
ARG   CD   C N N 64  
ARG   NE   N N N 65  
ARG   CZ   C N N 66  
ARG   NH1  N N N 67  
ARG   NH2  N N N 68  
ARG   OXT  O N N 69  
ARG   H    H N N 70  
ARG   H2   H N N 71  
ARG   HA   H N N 72  
ARG   HB2  H N N 73  
ARG   HB3  H N N 74  
ARG   HG2  H N N 75  
ARG   HG3  H N N 76  
ARG   HD2  H N N 77  
ARG   HD3  H N N 78  
ARG   HE   H N N 79  
ARG   HH11 H N N 80  
ARG   HH12 H N N 81  
ARG   HH21 H N N 82  
ARG   HH22 H N N 83  
ARG   HXT  H N N 84  
ASN   N    N N N 85  
ASN   CA   C N S 86  
ASN   C    C N N 87  
ASN   O    O N N 88  
ASN   CB   C N N 89  
ASN   CG   C N N 90  
ASN   OD1  O N N 91  
ASN   ND2  N N N 92  
ASN   OXT  O N N 93  
ASN   H    H N N 94  
ASN   H2   H N N 95  
ASN   HA   H N N 96  
ASN   HB2  H N N 97  
ASN   HB3  H N N 98  
ASN   HD21 H N N 99  
ASN   HD22 H N N 100 
ASN   HXT  H N N 101 
ASP   N    N N N 102 
ASP   CA   C N S 103 
ASP   C    C N N 104 
ASP   O    O N N 105 
ASP   CB   C N N 106 
ASP   CG   C N N 107 
ASP   OD1  O N N 108 
ASP   OD2  O N N 109 
ASP   OXT  O N N 110 
ASP   H    H N N 111 
ASP   H2   H N N 112 
ASP   HA   H N N 113 
ASP   HB2  H N N 114 
ASP   HB3  H N N 115 
ASP   HD2  H N N 116 
ASP   HXT  H N N 117 
CYS   N    N N N 118 
CYS   CA   C N R 119 
CYS   C    C N N 120 
CYS   O    O N N 121 
CYS   CB   C N N 122 
CYS   SG   S N N 123 
CYS   OXT  O N N 124 
CYS   H    H N N 125 
CYS   H2   H N N 126 
CYS   HA   H N N 127 
CYS   HB2  H N N 128 
CYS   HB3  H N N 129 
CYS   HG   H N N 130 
CYS   HXT  H N N 131 
GLN   N    N N N 132 
GLN   CA   C N S 133 
GLN   C    C N N 134 
GLN   O    O N N 135 
GLN   CB   C N N 136 
GLN   CG   C N N 137 
GLN   CD   C N N 138 
GLN   OE1  O N N 139 
GLN   NE2  N N N 140 
GLN   OXT  O N N 141 
GLN   H    H N N 142 
GLN   H2   H N N 143 
GLN   HA   H N N 144 
GLN   HB2  H N N 145 
GLN   HB3  H N N 146 
GLN   HG2  H N N 147 
GLN   HG3  H N N 148 
GLN   HE21 H N N 149 
GLN   HE22 H N N 150 
GLN   HXT  H N N 151 
GLU   N    N N N 152 
GLU   CA   C N S 153 
GLU   C    C N N 154 
GLU   O    O N N 155 
GLU   CB   C N N 156 
GLU   CG   C N N 157 
GLU   CD   C N N 158 
GLU   OE1  O N N 159 
GLU   OE2  O N N 160 
GLU   OXT  O N N 161 
GLU   H    H N N 162 
GLU   H2   H N N 163 
GLU   HA   H N N 164 
GLU   HB2  H N N 165 
GLU   HB3  H N N 166 
GLU   HG2  H N N 167 
GLU   HG3  H N N 168 
GLU   HE2  H N N 169 
GLU   HXT  H N N 170 
GLY   N    N N N 171 
GLY   CA   C N N 172 
GLY   C    C N N 173 
GLY   O    O N N 174 
GLY   OXT  O N N 175 
GLY   H    H N N 176 
GLY   H2   H N N 177 
GLY   HA2  H N N 178 
GLY   HA3  H N N 179 
GLY   HXT  H N N 180 
HIS   N    N N N 181 
HIS   CA   C N S 182 
HIS   C    C N N 183 
HIS   O    O N N 184 
HIS   CB   C N N 185 
HIS   CG   C Y N 186 
HIS   ND1  N Y N 187 
HIS   CD2  C Y N 188 
HIS   CE1  C Y N 189 
HIS   NE2  N Y N 190 
HIS   OXT  O N N 191 
HIS   H    H N N 192 
HIS   H2   H N N 193 
HIS   HA   H N N 194 
HIS   HB2  H N N 195 
HIS   HB3  H N N 196 
HIS   HD1  H N N 197 
HIS   HD2  H N N 198 
HIS   HE1  H N N 199 
HIS   HE2  H N N 200 
HIS   HXT  H N N 201 
HOH   O    O N N 202 
HOH   H1   H N N 203 
HOH   H2   H N N 204 
ILE   N    N N N 205 
ILE   CA   C N S 206 
ILE   C    C N N 207 
ILE   O    O N N 208 
ILE   CB   C N S 209 
ILE   CG1  C N N 210 
ILE   CG2  C N N 211 
ILE   CD1  C N N 212 
ILE   OXT  O N N 213 
ILE   H    H N N 214 
ILE   H2   H N N 215 
ILE   HA   H N N 216 
ILE   HB   H N N 217 
ILE   HG12 H N N 218 
ILE   HG13 H N N 219 
ILE   HG21 H N N 220 
ILE   HG22 H N N 221 
ILE   HG23 H N N 222 
ILE   HD11 H N N 223 
ILE   HD12 H N N 224 
ILE   HD13 H N N 225 
ILE   HXT  H N N 226 
LEU   N    N N N 227 
LEU   CA   C N S 228 
LEU   C    C N N 229 
LEU   O    O N N 230 
LEU   CB   C N N 231 
LEU   CG   C N N 232 
LEU   CD1  C N N 233 
LEU   CD2  C N N 234 
LEU   OXT  O N N 235 
LEU   H    H N N 236 
LEU   H2   H N N 237 
LEU   HA   H N N 238 
LEU   HB2  H N N 239 
LEU   HB3  H N N 240 
LEU   HG   H N N 241 
LEU   HD11 H N N 242 
LEU   HD12 H N N 243 
LEU   HD13 H N N 244 
LEU   HD21 H N N 245 
LEU   HD22 H N N 246 
LEU   HD23 H N N 247 
LEU   HXT  H N N 248 
LYS   N    N N N 249 
LYS   CA   C N S 250 
LYS   C    C N N 251 
LYS   O    O N N 252 
LYS   CB   C N N 253 
LYS   CG   C N N 254 
LYS   CD   C N N 255 
LYS   CE   C N N 256 
LYS   NZ   N N N 257 
LYS   OXT  O N N 258 
LYS   H    H N N 259 
LYS   H2   H N N 260 
LYS   HA   H N N 261 
LYS   HB2  H N N 262 
LYS   HB3  H N N 263 
LYS   HG2  H N N 264 
LYS   HG3  H N N 265 
LYS   HD2  H N N 266 
LYS   HD3  H N N 267 
LYS   HE2  H N N 268 
LYS   HE3  H N N 269 
LYS   HZ1  H N N 270 
LYS   HZ2  H N N 271 
LYS   HZ3  H N N 272 
LYS   HXT  H N N 273 
MET   N    N N N 274 
MET   CA   C N S 275 
MET   C    C N N 276 
MET   O    O N N 277 
MET   CB   C N N 278 
MET   CG   C N N 279 
MET   SD   S N N 280 
MET   CE   C N N 281 
MET   OXT  O N N 282 
MET   H    H N N 283 
MET   H2   H N N 284 
MET   HA   H N N 285 
MET   HB2  H N N 286 
MET   HB3  H N N 287 
MET   HG2  H N N 288 
MET   HG3  H N N 289 
MET   HE1  H N N 290 
MET   HE2  H N N 291 
MET   HE3  H N N 292 
MET   HXT  H N N 293 
PHE   N    N N N 294 
PHE   CA   C N S 295 
PHE   C    C N N 296 
PHE   O    O N N 297 
PHE   CB   C N N 298 
PHE   CG   C Y N 299 
PHE   CD1  C Y N 300 
PHE   CD2  C Y N 301 
PHE   CE1  C Y N 302 
PHE   CE2  C Y N 303 
PHE   CZ   C Y N 304 
PHE   OXT  O N N 305 
PHE   H    H N N 306 
PHE   H2   H N N 307 
PHE   HA   H N N 308 
PHE   HB2  H N N 309 
PHE   HB3  H N N 310 
PHE   HD1  H N N 311 
PHE   HD2  H N N 312 
PHE   HE1  H N N 313 
PHE   HE2  H N N 314 
PHE   HZ   H N N 315 
PHE   HXT  H N N 316 
PRO   N    N N N 317 
PRO   CA   C N S 318 
PRO   C    C N N 319 
PRO   O    O N N 320 
PRO   CB   C N N 321 
PRO   CG   C N N 322 
PRO   CD   C N N 323 
PRO   OXT  O N N 324 
PRO   H    H N N 325 
PRO   HA   H N N 326 
PRO   HB2  H N N 327 
PRO   HB3  H N N 328 
PRO   HG2  H N N 329 
PRO   HG3  H N N 330 
PRO   HD2  H N N 331 
PRO   HD3  H N N 332 
PRO   HXT  H N N 333 
SER   N    N N N 334 
SER   CA   C N S 335 
SER   C    C N N 336 
SER   O    O N N 337 
SER   CB   C N N 338 
SER   OG   O N N 339 
SER   OXT  O N N 340 
SER   H    H N N 341 
SER   H2   H N N 342 
SER   HA   H N N 343 
SER   HB2  H N N 344 
SER   HB3  H N N 345 
SER   HG   H N N 346 
SER   HXT  H N N 347 
THR   N    N N N 348 
THR   CA   C N S 349 
THR   C    C N N 350 
THR   O    O N N 351 
THR   CB   C N R 352 
THR   OG1  O N N 353 
THR   CG2  C N N 354 
THR   OXT  O N N 355 
THR   H    H N N 356 
THR   H2   H N N 357 
THR   HA   H N N 358 
THR   HB   H N N 359 
THR   HG1  H N N 360 
THR   HG21 H N N 361 
THR   HG22 H N N 362 
THR   HG23 H N N 363 
THR   HXT  H N N 364 
TRP   N    N N N 365 
TRP   CA   C N S 366 
TRP   C    C N N 367 
TRP   O    O N N 368 
TRP   CB   C N N 369 
TRP   CG   C Y N 370 
TRP   CD1  C Y N 371 
TRP   CD2  C Y N 372 
TRP   NE1  N Y N 373 
TRP   CE2  C Y N 374 
TRP   CE3  C Y N 375 
TRP   CZ2  C Y N 376 
TRP   CZ3  C Y N 377 
TRP   CH2  C Y N 378 
TRP   OXT  O N N 379 
TRP   H    H N N 380 
TRP   H2   H N N 381 
TRP   HA   H N N 382 
TRP   HB2  H N N 383 
TRP   HB3  H N N 384 
TRP   HD1  H N N 385 
TRP   HE1  H N N 386 
TRP   HE3  H N N 387 
TRP   HZ2  H N N 388 
TRP   HZ3  H N N 389 
TRP   HH2  H N N 390 
TRP   HXT  H N N 391 
TYR   N    N N N 392 
TYR   CA   C N S 393 
TYR   C    C N N 394 
TYR   O    O N N 395 
TYR   CB   C N N 396 
TYR   CG   C Y N 397 
TYR   CD1  C Y N 398 
TYR   CD2  C Y N 399 
TYR   CE1  C Y N 400 
TYR   CE2  C Y N 401 
TYR   CZ   C Y N 402 
TYR   OH   O N N 403 
TYR   OXT  O N N 404 
TYR   H    H N N 405 
TYR   H2   H N N 406 
TYR   HA   H N N 407 
TYR   HB2  H N N 408 
TYR   HB3  H N N 409 
TYR   HD1  H N N 410 
TYR   HD2  H N N 411 
TYR   HE1  H N N 412 
TYR   HE2  H N N 413 
TYR   HH   H N N 414 
TYR   HXT  H N N 415 
VAL   N    N N N 416 
VAL   CA   C N S 417 
VAL   C    C N N 418 
VAL   O    O N N 419 
VAL   CB   C N N 420 
VAL   CG1  C N N 421 
VAL   CG2  C N N 422 
VAL   OXT  O N N 423 
VAL   H    H N N 424 
VAL   H2   H N N 425 
VAL   HA   H N N 426 
VAL   HB   H N N 427 
VAL   HG11 H N N 428 
VAL   HG12 H N N 429 
VAL   HG13 H N N 430 
VAL   HG21 H N N 431 
VAL   HG22 H N N 432 
VAL   HG23 H N N 433 
VAL   HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BIW O26 C24  sing N N 1   
A1BIW N25 C24  sing Y N 2   
A1BIW N25 C19  doub Y N 3   
A1BIW C24 C23  doub Y N 4   
A1BIW C18 C19  sing Y N 5   
A1BIW C18 C17  doub Y N 6   
A1BIW C19 C20  sing Y N 7   
A1BIW C23 N22  sing Y N 8   
A1BIW C17 C16  sing Y N 9   
A1BIW C20 N22  doub Y N 10  
A1BIW C20 C21  sing Y N 11  
A1BIW C16 C21  doub Y N 12  
A1BIW C16 C15  sing N N 13  
A1BIW N14 C15  sing N N 14  
A1BIW N14 C3   sing N N 15  
A1BIW C15 O27  doub N N 16  
A1BIW C2  C3   sing N N 17  
A1BIW C2  C1   sing N N 18  
A1BIW C3  C4   sing N N 19  
A1BIW C1  C11  sing N N 20  
A1BIW C5  C4   doub Y N 21  
A1BIW C5  C6   sing Y N 22  
A1BIW C4  C9   sing Y N 23  
A1BIW C11 S10  sing N N 24  
A1BIW C6  C7   doub Y N 25  
A1BIW C9  S10  sing N N 26  
A1BIW C9  C8   doub Y N 27  
A1BIW C7  C8   sing Y N 28  
A1BIW S10 O12  doub N N 29  
A1BIW S10 O13  doub N N 30  
A1BIW C5  H1   sing N N 31  
A1BIW C6  H2   sing N N 32  
A1BIW C7  H3   sing N N 33  
A1BIW C8  H4   sing N N 34  
A1BIW C17 H5   sing N N 35  
A1BIW C21 H6   sing N N 36  
A1BIW C1  H7   sing N N 37  
A1BIW C1  H8   sing N N 38  
A1BIW C2  H9   sing N N 39  
A1BIW C2  H10  sing N N 40  
A1BIW C3  H11  sing N N 41  
A1BIW C11 H12  sing N N 42  
A1BIW C11 H13  sing N N 43  
A1BIW N14 H14  sing N N 44  
A1BIW C18 H15  sing N N 45  
A1BIW C23 H16  sing N N 46  
A1BIW O26 H17  sing N N 47  
ALA   N   CA   sing N N 48  
ALA   N   H    sing N N 49  
ALA   N   H2   sing N N 50  
ALA   CA  C    sing N N 51  
ALA   CA  CB   sing N N 52  
ALA   CA  HA   sing N N 53  
ALA   C   O    doub N N 54  
ALA   C   OXT  sing N N 55  
ALA   CB  HB1  sing N N 56  
ALA   CB  HB2  sing N N 57  
ALA   CB  HB3  sing N N 58  
ALA   OXT HXT  sing N N 59  
ARG   N   CA   sing N N 60  
ARG   N   H    sing N N 61  
ARG   N   H2   sing N N 62  
ARG   CA  C    sing N N 63  
ARG   CA  CB   sing N N 64  
ARG   CA  HA   sing N N 65  
ARG   C   O    doub N N 66  
ARG   C   OXT  sing N N 67  
ARG   CB  CG   sing N N 68  
ARG   CB  HB2  sing N N 69  
ARG   CB  HB3  sing N N 70  
ARG   CG  CD   sing N N 71  
ARG   CG  HG2  sing N N 72  
ARG   CG  HG3  sing N N 73  
ARG   CD  NE   sing N N 74  
ARG   CD  HD2  sing N N 75  
ARG   CD  HD3  sing N N 76  
ARG   NE  CZ   sing N N 77  
ARG   NE  HE   sing N N 78  
ARG   CZ  NH1  sing N N 79  
ARG   CZ  NH2  doub N N 80  
ARG   NH1 HH11 sing N N 81  
ARG   NH1 HH12 sing N N 82  
ARG   NH2 HH21 sing N N 83  
ARG   NH2 HH22 sing N N 84  
ARG   OXT HXT  sing N N 85  
ASN   N   CA   sing N N 86  
ASN   N   H    sing N N 87  
ASN   N   H2   sing N N 88  
ASN   CA  C    sing N N 89  
ASN   CA  CB   sing N N 90  
ASN   CA  HA   sing N N 91  
ASN   C   O    doub N N 92  
ASN   C   OXT  sing N N 93  
ASN   CB  CG   sing N N 94  
ASN   CB  HB2  sing N N 95  
ASN   CB  HB3  sing N N 96  
ASN   CG  OD1  doub N N 97  
ASN   CG  ND2  sing N N 98  
ASN   ND2 HD21 sing N N 99  
ASN   ND2 HD22 sing N N 100 
ASN   OXT HXT  sing N N 101 
ASP   N   CA   sing N N 102 
ASP   N   H    sing N N 103 
ASP   N   H2   sing N N 104 
ASP   CA  C    sing N N 105 
ASP   CA  CB   sing N N 106 
ASP   CA  HA   sing N N 107 
ASP   C   O    doub N N 108 
ASP   C   OXT  sing N N 109 
ASP   CB  CG   sing N N 110 
ASP   CB  HB2  sing N N 111 
ASP   CB  HB3  sing N N 112 
ASP   CG  OD1  doub N N 113 
ASP   CG  OD2  sing N N 114 
ASP   OD2 HD2  sing N N 115 
ASP   OXT HXT  sing N N 116 
CYS   N   CA   sing N N 117 
CYS   N   H    sing N N 118 
CYS   N   H2   sing N N 119 
CYS   CA  C    sing N N 120 
CYS   CA  CB   sing N N 121 
CYS   CA  HA   sing N N 122 
CYS   C   O    doub N N 123 
CYS   C   OXT  sing N N 124 
CYS   CB  SG   sing N N 125 
CYS   CB  HB2  sing N N 126 
CYS   CB  HB3  sing N N 127 
CYS   SG  HG   sing N N 128 
CYS   OXT HXT  sing N N 129 
GLN   N   CA   sing N N 130 
GLN   N   H    sing N N 131 
GLN   N   H2   sing N N 132 
GLN   CA  C    sing N N 133 
GLN   CA  CB   sing N N 134 
GLN   CA  HA   sing N N 135 
GLN   C   O    doub N N 136 
GLN   C   OXT  sing N N 137 
GLN   CB  CG   sing N N 138 
GLN   CB  HB2  sing N N 139 
GLN   CB  HB3  sing N N 140 
GLN   CG  CD   sing N N 141 
GLN   CG  HG2  sing N N 142 
GLN   CG  HG3  sing N N 143 
GLN   CD  OE1  doub N N 144 
GLN   CD  NE2  sing N N 145 
GLN   NE2 HE21 sing N N 146 
GLN   NE2 HE22 sing N N 147 
GLN   OXT HXT  sing N N 148 
GLU   N   CA   sing N N 149 
GLU   N   H    sing N N 150 
GLU   N   H2   sing N N 151 
GLU   CA  C    sing N N 152 
GLU   CA  CB   sing N N 153 
GLU   CA  HA   sing N N 154 
GLU   C   O    doub N N 155 
GLU   C   OXT  sing N N 156 
GLU   CB  CG   sing N N 157 
GLU   CB  HB2  sing N N 158 
GLU   CB  HB3  sing N N 159 
GLU   CG  CD   sing N N 160 
GLU   CG  HG2  sing N N 161 
GLU   CG  HG3  sing N N 162 
GLU   CD  OE1  doub N N 163 
GLU   CD  OE2  sing N N 164 
GLU   OE2 HE2  sing N N 165 
GLU   OXT HXT  sing N N 166 
GLY   N   CA   sing N N 167 
GLY   N   H    sing N N 168 
GLY   N   H2   sing N N 169 
GLY   CA  C    sing N N 170 
GLY   CA  HA2  sing N N 171 
GLY   CA  HA3  sing N N 172 
GLY   C   O    doub N N 173 
GLY   C   OXT  sing N N 174 
GLY   OXT HXT  sing N N 175 
HIS   N   CA   sing N N 176 
HIS   N   H    sing N N 177 
HIS   N   H2   sing N N 178 
HIS   CA  C    sing N N 179 
HIS   CA  CB   sing N N 180 
HIS   CA  HA   sing N N 181 
HIS   C   O    doub N N 182 
HIS   C   OXT  sing N N 183 
HIS   CB  CG   sing N N 184 
HIS   CB  HB2  sing N N 185 
HIS   CB  HB3  sing N N 186 
HIS   CG  ND1  sing Y N 187 
HIS   CG  CD2  doub Y N 188 
HIS   ND1 CE1  doub Y N 189 
HIS   ND1 HD1  sing N N 190 
HIS   CD2 NE2  sing Y N 191 
HIS   CD2 HD2  sing N N 192 
HIS   CE1 NE2  sing Y N 193 
HIS   CE1 HE1  sing N N 194 
HIS   NE2 HE2  sing N N 195 
HIS   OXT HXT  sing N N 196 
HOH   O   H1   sing N N 197 
HOH   O   H2   sing N N 198 
ILE   N   CA   sing N N 199 
ILE   N   H    sing N N 200 
ILE   N   H2   sing N N 201 
ILE   CA  C    sing N N 202 
ILE   CA  CB   sing N N 203 
ILE   CA  HA   sing N N 204 
ILE   C   O    doub N N 205 
ILE   C   OXT  sing N N 206 
ILE   CB  CG1  sing N N 207 
ILE   CB  CG2  sing N N 208 
ILE   CB  HB   sing N N 209 
ILE   CG1 CD1  sing N N 210 
ILE   CG1 HG12 sing N N 211 
ILE   CG1 HG13 sing N N 212 
ILE   CG2 HG21 sing N N 213 
ILE   CG2 HG22 sing N N 214 
ILE   CG2 HG23 sing N N 215 
ILE   CD1 HD11 sing N N 216 
ILE   CD1 HD12 sing N N 217 
ILE   CD1 HD13 sing N N 218 
ILE   OXT HXT  sing N N 219 
LEU   N   CA   sing N N 220 
LEU   N   H    sing N N 221 
LEU   N   H2   sing N N 222 
LEU   CA  C    sing N N 223 
LEU   CA  CB   sing N N 224 
LEU   CA  HA   sing N N 225 
LEU   C   O    doub N N 226 
LEU   C   OXT  sing N N 227 
LEU   CB  CG   sing N N 228 
LEU   CB  HB2  sing N N 229 
LEU   CB  HB3  sing N N 230 
LEU   CG  CD1  sing N N 231 
LEU   CG  CD2  sing N N 232 
LEU   CG  HG   sing N N 233 
LEU   CD1 HD11 sing N N 234 
LEU   CD1 HD12 sing N N 235 
LEU   CD1 HD13 sing N N 236 
LEU   CD2 HD21 sing N N 237 
LEU   CD2 HD22 sing N N 238 
LEU   CD2 HD23 sing N N 239 
LEU   OXT HXT  sing N N 240 
LYS   N   CA   sing N N 241 
LYS   N   H    sing N N 242 
LYS   N   H2   sing N N 243 
LYS   CA  C    sing N N 244 
LYS   CA  CB   sing N N 245 
LYS   CA  HA   sing N N 246 
LYS   C   O    doub N N 247 
LYS   C   OXT  sing N N 248 
LYS   CB  CG   sing N N 249 
LYS   CB  HB2  sing N N 250 
LYS   CB  HB3  sing N N 251 
LYS   CG  CD   sing N N 252 
LYS   CG  HG2  sing N N 253 
LYS   CG  HG3  sing N N 254 
LYS   CD  CE   sing N N 255 
LYS   CD  HD2  sing N N 256 
LYS   CD  HD3  sing N N 257 
LYS   CE  NZ   sing N N 258 
LYS   CE  HE2  sing N N 259 
LYS   CE  HE3  sing N N 260 
LYS   NZ  HZ1  sing N N 261 
LYS   NZ  HZ2  sing N N 262 
LYS   NZ  HZ3  sing N N 263 
LYS   OXT HXT  sing N N 264 
MET   N   CA   sing N N 265 
MET   N   H    sing N N 266 
MET   N   H2   sing N N 267 
MET   CA  C    sing N N 268 
MET   CA  CB   sing N N 269 
MET   CA  HA   sing N N 270 
MET   C   O    doub N N 271 
MET   C   OXT  sing N N 272 
MET   CB  CG   sing N N 273 
MET   CB  HB2  sing N N 274 
MET   CB  HB3  sing N N 275 
MET   CG  SD   sing N N 276 
MET   CG  HG2  sing N N 277 
MET   CG  HG3  sing N N 278 
MET   SD  CE   sing N N 279 
MET   CE  HE1  sing N N 280 
MET   CE  HE2  sing N N 281 
MET   CE  HE3  sing N N 282 
MET   OXT HXT  sing N N 283 
PHE   N   CA   sing N N 284 
PHE   N   H    sing N N 285 
PHE   N   H2   sing N N 286 
PHE   CA  C    sing N N 287 
PHE   CA  CB   sing N N 288 
PHE   CA  HA   sing N N 289 
PHE   C   O    doub N N 290 
PHE   C   OXT  sing N N 291 
PHE   CB  CG   sing N N 292 
PHE   CB  HB2  sing N N 293 
PHE   CB  HB3  sing N N 294 
PHE   CG  CD1  doub Y N 295 
PHE   CG  CD2  sing Y N 296 
PHE   CD1 CE1  sing Y N 297 
PHE   CD1 HD1  sing N N 298 
PHE   CD2 CE2  doub Y N 299 
PHE   CD2 HD2  sing N N 300 
PHE   CE1 CZ   doub Y N 301 
PHE   CE1 HE1  sing N N 302 
PHE   CE2 CZ   sing Y N 303 
PHE   CE2 HE2  sing N N 304 
PHE   CZ  HZ   sing N N 305 
PHE   OXT HXT  sing N N 306 
PRO   N   CA   sing N N 307 
PRO   N   CD   sing N N 308 
PRO   N   H    sing N N 309 
PRO   CA  C    sing N N 310 
PRO   CA  CB   sing N N 311 
PRO   CA  HA   sing N N 312 
PRO   C   O    doub N N 313 
PRO   C   OXT  sing N N 314 
PRO   CB  CG   sing N N 315 
PRO   CB  HB2  sing N N 316 
PRO   CB  HB3  sing N N 317 
PRO   CG  CD   sing N N 318 
PRO   CG  HG2  sing N N 319 
PRO   CG  HG3  sing N N 320 
PRO   CD  HD2  sing N N 321 
PRO   CD  HD3  sing N N 322 
PRO   OXT HXT  sing N N 323 
SER   N   CA   sing N N 324 
SER   N   H    sing N N 325 
SER   N   H2   sing N N 326 
SER   CA  C    sing N N 327 
SER   CA  CB   sing N N 328 
SER   CA  HA   sing N N 329 
SER   C   O    doub N N 330 
SER   C   OXT  sing N N 331 
SER   CB  OG   sing N N 332 
SER   CB  HB2  sing N N 333 
SER   CB  HB3  sing N N 334 
SER   OG  HG   sing N N 335 
SER   OXT HXT  sing N N 336 
THR   N   CA   sing N N 337 
THR   N   H    sing N N 338 
THR   N   H2   sing N N 339 
THR   CA  C    sing N N 340 
THR   CA  CB   sing N N 341 
THR   CA  HA   sing N N 342 
THR   C   O    doub N N 343 
THR   C   OXT  sing N N 344 
THR   CB  OG1  sing N N 345 
THR   CB  CG2  sing N N 346 
THR   CB  HB   sing N N 347 
THR   OG1 HG1  sing N N 348 
THR   CG2 HG21 sing N N 349 
THR   CG2 HG22 sing N N 350 
THR   CG2 HG23 sing N N 351 
THR   OXT HXT  sing N N 352 
TRP   N   CA   sing N N 353 
TRP   N   H    sing N N 354 
TRP   N   H2   sing N N 355 
TRP   CA  C    sing N N 356 
TRP   CA  CB   sing N N 357 
TRP   CA  HA   sing N N 358 
TRP   C   O    doub N N 359 
TRP   C   OXT  sing N N 360 
TRP   CB  CG   sing N N 361 
TRP   CB  HB2  sing N N 362 
TRP   CB  HB3  sing N N 363 
TRP   CG  CD1  doub Y N 364 
TRP   CG  CD2  sing Y N 365 
TRP   CD1 NE1  sing Y N 366 
TRP   CD1 HD1  sing N N 367 
TRP   CD2 CE2  doub Y N 368 
TRP   CD2 CE3  sing Y N 369 
TRP   NE1 CE2  sing Y N 370 
TRP   NE1 HE1  sing N N 371 
TRP   CE2 CZ2  sing Y N 372 
TRP   CE3 CZ3  doub Y N 373 
TRP   CE3 HE3  sing N N 374 
TRP   CZ2 CH2  doub Y N 375 
TRP   CZ2 HZ2  sing N N 376 
TRP   CZ3 CH2  sing Y N 377 
TRP   CZ3 HZ3  sing N N 378 
TRP   CH2 HH2  sing N N 379 
TRP   OXT HXT  sing N N 380 
TYR   N   CA   sing N N 381 
TYR   N   H    sing N N 382 
TYR   N   H2   sing N N 383 
TYR   CA  C    sing N N 384 
TYR   CA  CB   sing N N 385 
TYR   CA  HA   sing N N 386 
TYR   C   O    doub N N 387 
TYR   C   OXT  sing N N 388 
TYR   CB  CG   sing N N 389 
TYR   CB  HB2  sing N N 390 
TYR   CB  HB3  sing N N 391 
TYR   CG  CD1  doub Y N 392 
TYR   CG  CD2  sing Y N 393 
TYR   CD1 CE1  sing Y N 394 
TYR   CD1 HD1  sing N N 395 
TYR   CD2 CE2  doub Y N 396 
TYR   CD2 HD2  sing N N 397 
TYR   CE1 CZ   doub Y N 398 
TYR   CE1 HE1  sing N N 399 
TYR   CE2 CZ   sing Y N 400 
TYR   CE2 HE2  sing N N 401 
TYR   CZ  OH   sing N N 402 
TYR   OH  HH   sing N N 403 
TYR   OXT HXT  sing N N 404 
VAL   N   CA   sing N N 405 
VAL   N   H    sing N N 406 
VAL   N   H2   sing N N 407 
VAL   CA  C    sing N N 408 
VAL   CA  CB   sing N N 409 
VAL   CA  HA   sing N N 410 
VAL   C   O    doub N N 411 
VAL   C   OXT  sing N N 412 
VAL   CB  CG1  sing N N 413 
VAL   CB  CG2  sing N N 414 
VAL   CB  HB   sing N N 415 
VAL   CG1 HG11 sing N N 416 
VAL   CG1 HG12 sing N N 417 
VAL   CG1 HG13 sing N N 418 
VAL   CG2 HG21 sing N N 419 
VAL   CG2 HG22 sing N N 420 
VAL   CG2 HG23 sing N N 421 
VAL   OXT HXT  sing N N 422 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6VYC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EJP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012884 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007544 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008347 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
X 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN   A 1 21  ? -34.343 -34.509 17.385  1.00 105.39 ? 394 GLN   A N   1 
ATOM   2    C CA  . GLN   A 1 21  ? -33.108 -34.164 16.632  1.00 103.26 ? 394 GLN   A CA  1 
ATOM   3    C C   . GLN   A 1 21  ? -32.933 -35.140 15.466  1.00 98.04  ? 394 GLN   A C   1 
ATOM   4    O O   . GLN   A 1 21  ? -32.285 -36.178 15.612  1.00 105.23 ? 394 GLN   A O   1 
ATOM   5    C CB  . GLN   A 1 21  ? -31.894 -34.157 17.564  1.00 102.36 ? 394 GLN   A CB  1 
ATOM   6    N N   . PRO   A 1 22  ? -33.512 -34.842 14.277  1.00 87.67  ? 395 PRO   A N   1 
ATOM   7    C CA  . PRO   A 1 22  ? -33.243 -35.627 13.065  1.00 79.02  ? 395 PRO   A CA  1 
ATOM   8    C C   . PRO   A 1 22  ? -31.941 -35.286 12.335  1.00 68.79  ? 395 PRO   A C   1 
ATOM   9    O O   . PRO   A 1 22  ? -31.615 -35.924 11.337  1.00 67.46  ? 395 PRO   A O   1 
ATOM   10   C CB  . PRO   A 1 22  ? -34.483 -35.310 12.214  1.00 79.46  ? 395 PRO   A CB  1 
ATOM   11   C CG  . PRO   A 1 22  ? -34.824 -33.878 12.578  1.00 80.99  ? 395 PRO   A CG  1 
ATOM   12   C CD  . PRO   A 1 22  ? -34.470 -33.744 14.048  1.00 84.67  ? 395 PRO   A CD  1 
ATOM   13   N N   . PHE   A 1 23  ? -31.225 -34.262 12.826  1.00 58.86  ? 396 PHE   A N   1 
ATOM   14   C CA  . PHE   A 1 23  ? -29.901 -33.901 12.347  1.00 51.41  ? 396 PHE   A CA  1 
ATOM   15   C C   . PHE   A 1 23  ? -29.027 -33.519 13.534  1.00 51.74  ? 396 PHE   A C   1 
ATOM   16   O O   . PHE   A 1 23  ? -29.534 -33.009 14.525  1.00 51.81  ? 396 PHE   A O   1 
ATOM   17   C CB  . PHE   A 1 23  ? -29.913 -32.680 11.421  1.00 49.00  ? 396 PHE   A CB  1 
ATOM   18   C CG  . PHE   A 1 23  ? -30.745 -32.852 10.160  1.00 45.57  ? 396 PHE   A CG  1 
ATOM   19   C CD1 . PHE   A 1 23  ? -30.241 -33.549 9.067   1.00 48.44  ? 396 PHE   A CD1 1 
ATOM   20   C CD2 . PHE   A 1 23  ? -32.023 -32.316 10.074  1.00 43.99  ? 396 PHE   A CD2 1 
ATOM   21   C CE1 . PHE   A 1 23  ? -31.007 -33.718 7.924   1.00 52.68  ? 396 PHE   A CE1 1 
ATOM   22   C CE2 . PHE   A 1 23  ? -32.781 -32.480 8.925   1.00 46.73  ? 396 PHE   A CE2 1 
ATOM   23   C CZ  . PHE   A 1 23  ? -32.279 -33.191 7.859   1.00 51.45  ? 396 PHE   A CZ  1 
ATOM   24   N N   . ILE   A 1 24  ? -27.713 -33.723 13.398  1.00 54.17  ? 397 ILE   A N   1 
ATOM   25   C CA  . ILE   A 1 24  ? -26.744 -33.172 14.333  1.00 59.82  ? 397 ILE   A CA  1 
ATOM   26   C C   . ILE   A 1 24  ? -25.966 -32.041 13.647  1.00 55.79  ? 397 ILE   A C   1 
ATOM   27   O O   . ILE   A 1 24  ? -25.461 -32.197 12.534  1.00 49.94  ? 397 ILE   A O   1 
ATOM   28   C CB  . ILE   A 1 24  ? -25.813 -34.283 14.866  1.00 65.63  ? 397 ILE   A CB  1 
ATOM   29   C CG1 . ILE   A 1 24  ? -26.596 -35.353 15.650  1.00 71.20  ? 397 ILE   A CG1 1 
ATOM   30   C CG2 . ILE   A 1 24  ? -24.666 -33.705 15.701  1.00 64.49  ? 397 ILE   A CG2 1 
ATOM   31   N N   . VAL   A 1 25  ? -25.830 -30.914 14.353  1.00 55.00  ? 398 VAL   A N   1 
ATOM   32   C CA  . VAL   A 1 25  ? -25.106 -29.757 13.855  1.00 53.94  ? 398 VAL   A CA  1 
ATOM   33   C C   . VAL   A 1 25  ? -23.631 -29.917 14.213  1.00 50.67  ? 398 VAL   A C   1 
ATOM   34   O O   . VAL   A 1 25  ? -23.244 -29.690 15.352  1.00 57.88  ? 398 VAL   A O   1 
ATOM   35   C CB  . VAL   A 1 25  ? -25.698 -28.448 14.422  1.00 55.17  ? 398 VAL   A CB  1 
ATOM   36   C CG1 . VAL   A 1 25  ? -24.990 -27.206 13.880  1.00 51.55  ? 398 VAL   A CG1 1 
ATOM   37   C CG2 . VAL   A 1 25  ? -27.206 -28.350 14.192  1.00 55.02  ? 398 VAL   A CG2 1 
ATOM   38   N N   . LEU   A 1 26  ? -22.807 -30.285 13.225  1.00 51.93  ? 399 LEU   A N   1 
ATOM   39   C CA  . LEU   A 1 26  ? -21.375 -30.433 13.434  1.00 52.75  ? 399 LEU   A CA  1 
ATOM   40   C C   . LEU   A 1 26  ? -20.680 -29.073 13.476  1.00 61.57  ? 399 LEU   A C   1 
ATOM   41   O O   . LEU   A 1 26  ? -19.513 -29.003 13.863  1.00 64.99  ? 399 LEU   A O   1 
ATOM   42   C CB  . LEU   A 1 26  ? -20.737 -31.296 12.350  1.00 49.92  ? 399 LEU   A CB  1 
ATOM   43   C CG  . LEU   A 1 26  ? -21.231 -32.738 12.236  1.00 53.82  ? 399 LEU   A CG  1 
ATOM   44   C CD1 . LEU   A 1 26  ? -20.457 -33.419 11.134  1.00 55.08  ? 399 LEU   A CD1 1 
ATOM   45   C CD2 . LEU   A 1 26  ? -21.117 -33.514 13.543  1.00 55.20  ? 399 LEU   A CD2 1 
ATOM   46   N N   . GLY   A 1 27  ? -21.348 -28.001 13.024  1.00 63.75  ? 400 GLY   A N   1 
ATOM   47   C CA  . GLY   A 1 27  ? -20.782 -26.667 13.173  1.00 59.68  ? 400 GLY   A CA  1 
ATOM   48   C C   . GLY   A 1 27  ? -21.318 -25.649 12.169  1.00 58.17  ? 400 GLY   A C   1 
ATOM   49   O O   . GLY   A 1 27  ? -22.093 -25.973 11.269  1.00 53.48  ? 400 GLY   A O   1 
ATOM   50   N N   . GLN   A 1 28  ? -20.866 -24.404 12.350  1.00 56.05  ? 401 GLN   A N   1 
ATOM   51   C CA  . GLN   A 1 28  ? -21.359 -23.266 11.598  1.00 55.77  ? 401 GLN   A CA  1 
ATOM   52   C C   . GLN   A 1 28  ? -20.225 -22.263 11.463  1.00 54.92  ? 401 GLN   A C   1 
ATOM   53   O O   . GLN   A 1 28  ? -19.811 -21.682 12.458  1.00 60.02  ? 401 GLN   A O   1 
ATOM   54   C CB  . GLN   A 1 28  ? -22.549 -22.611 12.300  1.00 54.75  ? 401 GLN   A CB  1 
ATOM   55   C CG  . GLN   A 1 28  ? -23.258 -21.568 11.445  1.00 54.95  ? 401 GLN   A CG  1 
ATOM   56   C CD  . GLN   A 1 28  ? -24.479 -20.983 12.113  1.00 55.82  ? 401 GLN   A CD  1 
ATOM   57   O OE1 . GLN   A 1 28  ? -24.372 -20.143 13.014  1.00 61.31  ? 401 GLN   A OE1 1 
ATOM   58   N NE2 . GLN   A 1 28  ? -25.651 -21.422 11.671  1.00 56.01  ? 401 GLN   A NE2 1 
ATOM   59   N N   . GLU   A 1 29  ? -19.719 -22.103 10.237  1.00 56.58  ? 402 GLU   A N   1 
ATOM   60   C CA  . GLU   A 1 29  ? -18.729 -21.087 9.922   1.00 56.91  ? 402 GLU   A CA  1 
ATOM   61   C C   . GLU   A 1 29  ? -19.394 -19.974 9.113   1.00 56.60  ? 402 GLU   A C   1 
ATOM   62   O O   . GLU   A 1 29  ? -20.558 -20.078 8.719   1.00 54.79  ? 402 GLU   A O   1 
ATOM   63   C CB  . GLU   A 1 29  ? -17.548 -21.719 9.178   1.00 64.65  ? 402 GLU   A CB  1 
ATOM   64   C CG  . GLU   A 1 29  ? -16.667 -22.624 10.042  1.00 70.69  ? 402 GLU   A CG  1 
ATOM   65   C CD  . GLU   A 1 29  ? -17.003 -24.103 9.931   1.00 81.05  ? 402 GLU   A CD  1 
ATOM   66   O OE1 . GLU   A 1 29  ? -16.943 -24.635 8.794   1.00 75.65  ? 402 GLU   A OE1 1 
ATOM   67   O OE2 . GLU   A 1 29  ? -17.327 -24.726 10.970  1.00 87.46  ? 402 GLU   A OE2 1 
ATOM   68   N N   . GLU   A 1 30  ? -18.628 -18.913 8.849   1.00 53.93  ? 403 GLU   A N   1 
ATOM   69   C CA  . GLU   A 1 30  ? -19.130 -17.755 8.137   1.00 49.11  ? 403 GLU   A CA  1 
ATOM   70   C C   . GLU   A 1 30  ? -18.162 -17.386 7.023   1.00 51.34  ? 403 GLU   A C   1 
ATOM   71   O O   . GLU   A 1 30  ? -16.976 -17.216 7.282   1.00 57.63  ? 403 GLU   A O   1 
ATOM   72   C CB  . GLU   A 1 30  ? -19.262 -16.582 9.100   1.00 52.56  ? 403 GLU   A CB  1 
ATOM   73   C CG  . GLU   A 1 30  ? -19.712 -15.293 8.416   1.00 54.16  ? 403 GLU   A CG  1 
ATOM   74   C CD  . GLU   A 1 30  ? -19.955 -14.160 9.387   1.00 54.75  ? 403 GLU   A CD  1 
ATOM   75   O OE1 . GLU   A 1 30  ? -19.127 -13.222 9.398   1.00 53.59  ? 403 GLU   A OE1 1 
ATOM   76   O OE2 . GLU   A 1 30  ? -20.970 -14.217 10.119  1.00 52.55  ? 403 GLU   A OE2 1 
ATOM   77   N N   . TYR   A 1 31  ? -18.687 -17.279 5.791   1.00 46.66  ? 404 TYR   A N   1 
ATOM   78   C CA  . TYR   A 1 31  ? -17.963 -16.691 4.675   1.00 47.45  ? 404 TYR   A CA  1 
ATOM   79   C C   . TYR   A 1 31  ? -18.408 -15.237 4.500   1.00 48.61  ? 404 TYR   A C   1 
ATOM   80   O O   . TYR   A 1 31  ? -19.587 -14.970 4.249   1.00 49.96  ? 404 TYR   A O   1 
ATOM   81   C CB  . TYR   A 1 31  ? -18.210 -17.501 3.404   1.00 42.67  ? 404 TYR   A CB  1 
ATOM   82   C CG  . TYR   A 1 31  ? -17.418 -17.017 2.205   1.00 43.59  ? 404 TYR   A CG  1 
ATOM   83   C CD1 . TYR   A 1 31  ? -16.079 -17.351 2.057   1.00 46.87  ? 404 TYR   A CD1 1 
ATOM   84   C CD2 . TYR   A 1 31  ? -18.003 -16.232 1.220   1.00 42.36  ? 404 TYR   A CD2 1 
ATOM   85   C CE1 . TYR   A 1 31  ? -15.340 -16.913 0.972   1.00 40.03  ? 404 TYR   A CE1 1 
ATOM   86   C CE2 . TYR   A 1 31  ? -17.284 -15.813 0.115   1.00 41.46  ? 404 TYR   A CE2 1 
ATOM   87   C CZ  . TYR   A 1 31  ? -15.950 -16.160 -0.011  1.00 43.18  ? 404 TYR   A CZ  1 
ATOM   88   O OH  . TYR   A 1 31  ? -15.213 -15.756 -1.086  1.00 42.51  ? 404 TYR   A OH  1 
ATOM   89   N N   . GLY   A 1 32  ? -17.446 -14.311 4.611   1.00 48.16  ? 405 GLY   A N   1 
ATOM   90   C CA  . GLY   A 1 32  ? -17.750 -12.899 4.812   1.00 47.28  ? 405 GLY   A CA  1 
ATOM   91   C C   . GLY   A 1 32  ? -17.033 -11.986 3.819   1.00 45.30  ? 405 GLY   A C   1 
ATOM   92   O O   . GLY   A 1 32  ? -16.836 -10.811 4.117   1.00 55.71  ? 405 GLY   A O   1 
ATOM   93   N N   . GLU   A 1 33  ? -16.701 -12.511 2.633   1.00 44.10  ? 406 GLU   A N   1 
ATOM   94   C CA  . GLU   A 1 33  ? -15.965 -11.767 1.619   1.00 48.67  ? 406 GLU   A CA  1 
ATOM   95   C C   . GLU   A 1 33  ? -16.859 -10.833 0.795   1.00 51.69  ? 406 GLU   A C   1 
ATOM   96   O O   . GLU   A 1 33  ? -16.350 -9.941  0.114   1.00 49.84  ? 406 GLU   A O   1 
ATOM   97   C CB  . GLU   A 1 33  ? -15.321 -12.714 0.608   1.00 51.37  ? 406 GLU   A CB  1 
ATOM   98   C CG  . GLU   A 1 33  ? -14.281 -13.653 1.211   1.00 63.67  ? 406 GLU   A CG  1 
ATOM   99   C CD  . GLU   A 1 33  ? -13.026 -12.948 1.671   1.00 66.61  ? 406 GLU   A CD  1 
ATOM   100  O OE1 . GLU   A 1 33  ? -12.104 -12.919 0.837   1.00 72.43  ? 406 GLU   A OE1 1 
ATOM   101  O OE2 . GLU   A 1 33  ? -12.974 -12.455 2.820   1.00 62.01  ? 406 GLU   A OE2 1 
ATOM   102  N N   . HIS   A 1 34  ? -18.174 -11.095 0.774   1.00 51.32  ? 407 HIS   A N   1 
ATOM   103  C CA  . HIS   A 1 34  ? -19.118 -10.200 0.120   1.00 47.51  ? 407 HIS   A CA  1 
ATOM   104  C C   . HIS   A 1 34  ? -19.404 -9.036  1.067   1.00 50.94  ? 407 HIS   A C   1 
ATOM   105  O O   . HIS   A 1 34  ? -19.550 -9.250  2.271   1.00 49.13  ? 407 HIS   A O   1 
ATOM   106  C CB  . HIS   A 1 34  ? -20.411 -10.923 -0.277  1.00 40.77  ? 407 HIS   A CB  1 
ATOM   107  C CG  . HIS   A 1 34  ? -20.252 -11.935 -1.360  1.00 39.05  ? 407 HIS   A CG  1 
ATOM   108  N ND1 . HIS   A 1 34  ? -20.212 -11.615 -2.701  1.00 42.65  ? 407 HIS   A ND1 1 
ATOM   109  C CD2 . HIS   A 1 34  ? -20.130 -13.274 -1.293  1.00 37.06  ? 407 HIS   A CD2 1 
ATOM   110  C CE1 . HIS   A 1 34  ? -20.067 -12.727 -3.412  1.00 40.45  ? 407 HIS   A CE1 1 
ATOM   111  N NE2 . HIS   A 1 34  ? -20.024 -13.746 -2.575  1.00 39.30  ? 407 HIS   A NE2 1 
ATOM   112  N N   . HIS   A 1 35  ? -19.472 -7.815  0.512   1.00 52.69  ? 408 HIS   A N   1 
ATOM   113  C CA  . HIS   A 1 35  ? -19.743 -6.619  1.300   1.00 62.18  ? 408 HIS   A CA  1 
ATOM   114  C C   . HIS   A 1 35  ? -21.131 -6.057  0.992   1.00 59.57  ? 408 HIS   A C   1 
ATOM   115  O O   . HIS   A 1 35  ? -21.545 -5.077  1.610   1.00 58.19  ? 408 HIS   A O   1 
ATOM   116  C CB  . HIS   A 1 35  ? -18.607 -5.608  1.105   1.00 68.97  ? 408 HIS   A CB  1 
ATOM   117  C CG  . HIS   A 1 35  ? -17.301 -6.172  1.556   1.00 74.97  ? 408 HIS   A CG  1 
ATOM   118  N ND1 . HIS   A 1 35  ? -17.150 -6.757  2.799   1.00 79.72  ? 408 HIS   A ND1 1 
ATOM   119  C CD2 . HIS   A 1 35  ? -16.110 -6.261  0.950   1.00 73.56  ? 408 HIS   A CD2 1 
ATOM   120  C CE1 . HIS   A 1 35  ? -15.902 -7.183  2.933   1.00 79.51  ? 408 HIS   A CE1 1 
ATOM   121  N NE2 . HIS   A 1 35  ? -15.254 -6.893  1.820   1.00 81.34  ? 408 HIS   A NE2 1 
ATOM   122  N N   . SER   A 1 36  ? -21.858 -6.715  0.080   1.00 52.54  ? 409 SER   A N   1 
ATOM   123  C CA  . SER   A 1 36  ? -23.217 -6.336  -0.264  1.00 53.52  ? 409 SER   A CA  1 
ATOM   124  C C   . SER   A 1 36  ? -24.145 -7.546  -0.193  1.00 48.63  ? 409 SER   A C   1 
ATOM   125  O O   . SER   A 1 36  ? -23.693 -8.685  -0.315  1.00 47.24  ? 409 SER   A O   1 
ATOM   126  C CB  . SER   A 1 36  ? -23.248 -5.735  -1.636  1.00 56.85  ? 409 SER   A CB  1 
ATOM   127  O OG  . SER   A 1 36  ? -22.280 -4.705  -1.733  1.00 64.89  ? 409 SER   A OG  1 
ATOM   128  N N   . SER   A 1 37  ? -25.448 -7.265  -0.065  1.00 46.01  ? 410 SER   A N   1 
ATOM   129  C CA  . SER   A 1 37  ? -26.484 -8.280  0.024   1.00 45.06  ? 410 SER   A CA  1 
ATOM   130  C C   . SER   A 1 37  ? -26.291 -9.344  -1.052  1.00 42.28  ? 410 SER   A C   1 
ATOM   131  O O   . SER   A 1 37  ? -25.954 -9.035  -2.202  1.00 42.00  ? 410 SER   A O   1 
ATOM   132  C CB  . SER   A 1 37  ? -27.859 -7.680  -0.065  1.00 47.67  ? 410 SER   A CB  1 
ATOM   133  O OG  . SER   A 1 37  ? -28.856 -8.675  0.142   1.00 47.65  ? 410 SER   A OG  1 
ATOM   134  N N   . ILE   A 1 38  ? -26.495 -10.601 -0.632  1.00 38.57  ? 411 ILE   A N   1 
ATOM   135  C CA  . ILE   A 1 38  ? -26.318 -11.767 -1.482  1.00 37.25  ? 411 ILE   A CA  1 
ATOM   136  C C   . ILE   A 1 38  ? -27.536 -11.905 -2.387  1.00 34.21  ? 411 ILE   A C   1 
ATOM   137  O O   . ILE   A 1 38  ? -28.664 -11.748 -1.940  1.00 35.41  ? 411 ILE   A O   1 
ATOM   138  C CB  . ILE   A 1 38  ? -26.099 -13.036 -0.629  1.00 36.37  ? 411 ILE   A CB  1 
ATOM   139  C CG1 . ILE   A 1 38  ? -24.899 -12.887 0.288   1.00 35.69  ? 411 ILE   A CG1 1 
ATOM   140  C CG2 . ILE   A 1 38  ? -25.966 -14.276 -1.504  1.00 36.62  ? 411 ILE   A CG2 1 
ATOM   141  C CD1 . ILE   A 1 38  ? -23.617 -12.523 -0.442  1.00 35.53  ? 411 ILE   A CD1 1 
ATOM   142  N N   . MET   A 1 39  ? -27.281 -12.227 -3.651  1.00 34.65  ? 412 MET   A N   1 
ATOM   143  C CA  . MET   A 1 39  ? -28.332 -12.520 -4.604  1.00 36.34  ? 412 MET   A CA  1 
ATOM   144  C C   . MET   A 1 39  ? -28.522 -14.029 -4.696  1.00 36.60  ? 412 MET   A C   1 
ATOM   145  O O   . MET   A 1 39  ? -29.647 -14.508 -4.615  1.00 36.29  ? 412 MET   A O   1 
ATOM   146  C CB  . MET   A 1 39  ? -27.966 -11.958 -5.983  1.00 38.48  ? 412 MET   A CB  1 
ATOM   147  C CG  . MET   A 1 39  ? -29.147 -11.859 -6.926  1.00 45.13  ? 412 MET   A CG  1 
ATOM   148  S SD  . MET   A 1 39  ? -28.808 -10.991 -8.474  1.00 51.61  ? 412 MET   A SD  1 
ATOM   149  C CE  . MET   A 1 39  ? -27.907 -9.590  -7.801  1.00 42.41  ? 412 MET   A CE  1 
ATOM   150  N N   . HIS   A 1 40  ? -27.417 -14.745 -4.942  1.00 36.77  ? 413 HIS   A N   1 
ATOM   151  C CA  . HIS   A 1 40  ? -27.434 -16.181 -5.153  1.00 38.33  ? 413 HIS   A CA  1 
ATOM   152  C C   . HIS   A 1 40  ? -26.241 -16.808 -4.431  1.00 38.47  ? 413 HIS   A C   1 
ATOM   153  O O   . HIS   A 1 40  ? -25.186 -16.194 -4.322  1.00 39.80  ? 413 HIS   A O   1 
ATOM   154  C CB  . HIS   A 1 40  ? -27.357 -16.538 -6.642  1.00 39.07  ? 413 HIS   A CB  1 
ATOM   155  C CG  . HIS   A 1 40  ? -28.473 -16.035 -7.489  1.00 40.99  ? 413 HIS   A CG  1 
ATOM   156  N ND1 . HIS   A 1 40  ? -29.747 -16.553 -7.447  1.00 40.63  ? 413 HIS   A ND1 1 
ATOM   157  C CD2 . HIS   A 1 40  ? -28.496 -15.053 -8.409  1.00 37.80  ? 413 HIS   A CD2 1 
ATOM   158  C CE1 . HIS   A 1 40  ? -30.507 -15.893 -8.312  1.00 43.29  ? 413 HIS   A CE1 1 
ATOM   159  N NE2 . HIS   A 1 40  ? -29.766 -14.977 -8.911  1.00 35.59  ? 413 HIS   A NE2 1 
ATOM   160  N N   . CYS   A 1 41  ? -26.426 -18.029 -3.921  1.00 35.42  ? 414 CYS   A N   1 
ATOM   161  C CA  . CYS   A 1 41  ? -25.311 -18.854 -3.500  1.00 34.87  ? 414 CYS   A CA  1 
ATOM   162  C C   . CYS   A 1 41  ? -25.703 -20.304 -3.711  1.00 32.53  ? 414 CYS   A C   1 
ATOM   163  O O   . CYS   A 1 41  ? -26.698 -20.770 -3.165  1.00 33.91  ? 414 CYS   A O   1 
ATOM   164  C CB  . CYS   A 1 41  ? -24.863 -18.568 -2.075  1.00 34.38  ? 414 CYS   A CB  1 
ATOM   165  S SG  . CYS   A 1 41  ? -26.186 -18.727 -0.865  1.00 43.88  ? 414 CYS   A SG  1 
ATOM   166  N N   . ARG   A 1 42  ? -24.941 -20.972 -4.569  1.00 34.09  ? 415 ARG   A N   1 
ATOM   167  C CA  . ARG   A 1 42  ? -25.216 -22.339 -4.958  1.00 38.53  ? 415 ARG   A CA  1 
ATOM   168  C C   . ARG   A 1 42  ? -23.938 -23.158 -4.824  1.00 37.70  ? 415 ARG   A C   1 
ATOM   169  O O   . ARG   A 1 42  ? -22.865 -22.690 -5.196  1.00 36.71  ? 415 ARG   A O   1 
ATOM   170  C CB  . ARG   A 1 42  ? -25.738 -22.383 -6.393  1.00 39.93  ? 415 ARG   A CB  1 
ATOM   171  C CG  . ARG   A 1 42  ? -27.113 -21.750 -6.547  1.00 41.67  ? 415 ARG   A CG  1 
ATOM   172  C CD  . ARG   A 1 42  ? -28.152 -22.402 -5.653  1.00 41.91  ? 415 ARG   A CD  1 
ATOM   173  N NE  . ARG   A 1 42  ? -28.174 -23.850 -5.858  1.00 43.73  ? 415 ARG   A NE  1 
ATOM   174  C CZ  . ARG   A 1 42  ? -28.729 -24.452 -6.902  1.00 47.68  ? 415 ARG   A CZ  1 
ATOM   175  N NH1 . ARG   A 1 42  ? -29.446 -23.760 -7.774  1.00 47.39  ? 415 ARG   A NH1 1 
ATOM   176  N NH2 . ARG   A 1 42  ? -28.580 -25.752 -7.050  1.00 46.37  ? 415 ARG   A NH2 1 
ATOM   177  N N   . VAL   A 1 43  ? -24.093 -24.374 -4.289  1.00 38.65  ? 416 VAL   A N   1 
ATOM   178  C CA  . VAL   A 1 43  ? -23.031 -25.365 -4.250  1.00 37.52  ? 416 VAL   A CA  1 
ATOM   179  C C   . VAL   A 1 43  ? -22.978 -26.068 -5.598  1.00 33.34  ? 416 VAL   A C   1 
ATOM   180  O O   . VAL   A 1 43  ? -24.017 -26.354 -6.192  1.00 38.78  ? 416 VAL   A O   1 
ATOM   181  C CB  . VAL   A 1 43  ? -23.272 -26.370 -3.111  1.00 40.90  ? 416 VAL   A CB  1 
ATOM   182  C CG1 . VAL   A 1 43  ? -22.145 -27.398 -3.005  1.00 43.83  ? 416 VAL   A CG1 1 
ATOM   183  C CG2 . VAL   A 1 43  ? -23.465 -25.654 -1.782  1.00 39.18  ? 416 VAL   A CG2 1 
ATOM   184  N N   . ASP   A 1 44  ? -21.759 -26.354 -6.067  1.00 35.64  ? 417 ASP   A N   1 
ATOM   185  C CA  . ASP   A 1 44  ? -21.539 -27.027 -7.341  1.00 39.07  ? 417 ASP   A CA  1 
ATOM   186  C C   . ASP   A 1 44  ? -21.949 -28.495 -7.263  1.00 39.42  ? 417 ASP   A C   1 
ATOM   187  O O   . ASP   A 1 44  ? -22.337 -28.986 -6.211  1.00 41.69  ? 417 ASP   A O   1 
ATOM   188  C CB  . ASP   A 1 44  ? -20.083 -26.955 -7.762  1.00 44.58  ? 417 ASP   A CB  1 
ATOM   189  C CG  . ASP   A 1 44  ? -19.177 -27.940 -7.034  1.00 47.03  ? 417 ASP   A CG  1 
ATOM   190  O OD1 . ASP   A 1 44  ? -19.375 -28.124 -5.813  1.00 46.22  ? 417 ASP   A OD1 1 
ATOM   191  O OD2 . ASP   A 1 44  ? -18.282 -28.495 -7.694  1.00 50.29  ? 417 ASP   A OD2 1 
ATOM   192  N N   . CYS   A 1 45  ? -21.857 -29.197 -8.396  1.00 49.21  ? 418 CYS   A N   1 
ATOM   193  C CA  . CYS   A 1 45  ? -22.366 -30.557 -8.494  1.00 53.23  ? 418 CYS   A CA  1 
ATOM   194  C C   . CYS   A 1 45  ? -21.503 -31.561 -7.734  1.00 50.91  ? 418 CYS   A C   1 
ATOM   195  O O   . CYS   A 1 45  ? -21.997 -32.628 -7.389  1.00 56.41  ? 418 CYS   A O   1 
ATOM   196  C CB  . CYS   A 1 45  ? -22.499 -30.997 -9.942  1.00 54.44  ? 418 CYS   A CB  1 
ATOM   197  S SG  . CYS   A 1 45  ? -23.955 -30.265 -10.717 1.00 63.08  ? 418 CYS   A SG  1 
ATOM   198  N N   . SER   A 1 46  ? -20.230 -31.226 -7.496  1.00 50.01  ? 419 SER   A N   1 
ATOM   199  C CA  . SER   A 1 46  ? -19.344 -32.087 -6.732  1.00 51.54  ? 419 SER   A CA  1 
ATOM   200  C C   . SER   A 1 46  ? -19.670 -31.962 -5.249  1.00 57.92  ? 419 SER   A C   1 
ATOM   201  O O   . SER   A 1 46  ? -19.356 -32.861 -4.473  1.00 63.11  ? 419 SER   A O   1 
ATOM   202  C CB  . SER   A 1 46  ? -17.892 -31.766 -6.989  1.00 48.94  ? 419 SER   A CB  1 
ATOM   203  O OG  . SER   A 1 46  ? -17.493 -30.576 -6.319  1.00 48.47  ? 419 SER   A OG  1 
ATOM   204  N N   . GLY   A 1 47  ? -20.272 -30.833 -4.861  1.00 51.72  ? 420 GLY   A N   1 
ATOM   205  C CA  . GLY   A 1 47  ? -20.639 -30.605 -3.473  1.00 46.55  ? 420 GLY   A CA  1 
ATOM   206  C C   . GLY   A 1 47  ? -19.487 -29.987 -2.692  1.00 44.66  ? 420 GLY   A C   1 
ATOM   207  O O   . GLY   A 1 47  ? -19.514 -29.936 -1.459  1.00 42.19  ? 420 GLY   A O   1 
ATOM   208  N N   . ARG   A 1 48  ? -18.499 -29.478 -3.432  1.00 47.39  ? 421 ARG   A N   1 
ATOM   209  C CA  . ARG   A 1 48  ? -17.252 -29.029 -2.838  1.00 53.09  ? 421 ARG   A CA  1 
ATOM   210  C C   . ARG   A 1 48  ? -17.077 -27.517 -2.978  1.00 52.46  ? 421 ARG   A C   1 
ATOM   211  O O   . ARG   A 1 48  ? -16.278 -26.936 -2.244  1.00 58.77  ? 421 ARG   A O   1 
ATOM   212  C CB  . ARG   A 1 48  ? -16.111 -29.834 -3.475  1.00 61.94  ? 421 ARG   A CB  1 
ATOM   213  C CG  . ARG   A 1 48  ? -16.039 -31.276 -2.984  1.00 73.31  ? 421 ARG   A CG  1 
ATOM   214  C CD  . ARG   A 1 48  ? -15.200 -32.262 -3.825  1.00 80.21  ? 421 ARG   A CD  1 
ATOM   215  N NE  . ARG   A 1 48  ? -13.859 -31.826 -4.246  1.00 89.40  ? 421 ARG   A NE  1 
ATOM   216  C CZ  . ARG   A 1 48  ? -12.823 -31.510 -3.468  1.00 94.50  ? 421 ARG   A CZ  1 
ATOM   217  N NH1 . ARG   A 1 48  ? -12.941 -31.502 -2.151  1.00 99.90  ? 421 ARG   A NH1 1 
ATOM   218  N NH2 . ARG   A 1 48  ? -11.665 -31.183 -4.016  1.00 94.08  ? 421 ARG   A NH2 1 
ATOM   219  N N   . ARG   A 1 49  ? -17.820 -26.873 -3.893  1.00 46.69  ? 422 ARG   A N   1 
ATOM   220  C CA  . ARG   A 1 49  ? -17.569 -25.471 -4.211  1.00 49.28  ? 422 ARG   A CA  1 
ATOM   221  C C   . ARG   A 1 49  ? -18.861 -24.664 -4.107  1.00 43.93  ? 422 ARG   A C   1 
ATOM   222  O O   . ARG   A 1 49  ? -19.945 -25.177 -4.360  1.00 44.54  ? 422 ARG   A O   1 
ATOM   223  C CB  . ARG   A 1 49  ? -17.005 -25.262 -5.626  1.00 54.94  ? 422 ARG   A CB  1 
ATOM   224  C CG  . ARG   A 1 49  ? -15.667 -25.908 -5.962  1.00 58.16  ? 422 ARG   A CG  1 
ATOM   225  C CD  . ARG   A 1 49  ? -14.507 -25.361 -5.138  1.00 66.45  ? 422 ARG   A CD  1 
ATOM   226  N NE  . ARG   A 1 49  ? -13.227 -25.992 -5.494  1.00 76.77  ? 422 ARG   A NE  1 
ATOM   227  C CZ  . ARG   A 1 49  ? -12.547 -26.895 -4.769  1.00 82.84  ? 422 ARG   A CZ  1 
ATOM   228  N NH1 . ARG   A 1 49  ? -13.000 -27.336 -3.605  1.00 83.96  ? 422 ARG   A NH1 1 
ATOM   229  N NH2 . ARG   A 1 49  ? -11.400 -27.370 -5.218  1.00 85.05  ? 422 ARG   A NH2 1 
ATOM   230  N N   . VAL   A 1 50  ? -18.711 -23.389 -3.745  1.00 42.08  ? 423 VAL   A N   1 
ATOM   231  C CA  . VAL   A 1 50  ? -19.808 -22.445 -3.690  1.00 43.27  ? 423 VAL   A CA  1 
ATOM   232  C C   . VAL   A 1 50  ? -19.534 -21.327 -4.690  1.00 43.20  ? 423 VAL   A C   1 
ATOM   233  O O   . VAL   A 1 50  ? -18.420 -20.811 -4.772  1.00 43.73  ? 423 VAL   A O   1 
ATOM   234  C CB  . VAL   A 1 50  ? -20.016 -21.854 -2.285  1.00 44.81  ? 423 VAL   A CB  1 
ATOM   235  C CG1 . VAL   A 1 50  ? -21.140 -20.813 -2.279  1.00 42.77  ? 423 VAL   A CG1 1 
ATOM   236  C CG2 . VAL   A 1 50  ? -20.265 -22.939 -1.243  1.00 41.02  ? 423 VAL   A CG2 1 
ATOM   237  N N   . ALA   A 1 51  ? -20.569 -20.982 -5.454  1.00 40.19  ? 424 ALA   A N   1 
ATOM   238  C CA  . ALA   A 1 51  ? -20.583 -19.763 -6.242  1.00 36.54  ? 424 ALA   A CA  1 
ATOM   239  C C   . ALA   A 1 51  ? -21.641 -18.850 -5.655  1.00 35.17  ? 424 ALA   A C   1 
ATOM   240  O O   . ALA   A 1 51  ? -22.798 -19.255 -5.512  1.00 34.28  ? 424 ALA   A O   1 
ATOM   241  C CB  . ALA   A 1 51  ? -20.856 -20.076 -7.681  1.00 36.50  ? 424 ALA   A CB  1 
ATOM   242  N N   . SER   A 1 52  ? -21.200 -17.665 -5.229  1.00 36.26  ? 425 SER   A N   1 
ATOM   243  C CA  . SER   A 1 52  ? -22.083 -16.677 -4.640  1.00 37.68  ? 425 SER   A CA  1 
ATOM   244  C C   . SER   A 1 52  ? -21.960 -15.359 -5.409  1.00 40.08  ? 425 SER   A C   1 
ATOM   245  O O   . SER   A 1 52  ? -20.897 -15.020 -5.911  1.00 42.92  ? 425 SER   A O   1 
ATOM   246  C CB  . SER   A 1 52  ? -21.805 -16.509 -3.171  1.00 36.62  ? 425 SER   A CB  1 
ATOM   247  O OG  . SER   A 1 52  ? -20.409 -16.388 -2.930  1.00 36.39  ? 425 SER   A OG  1 
ATOM   248  N N   . LEU   A 1 53  ? -23.080 -14.640 -5.507  1.00 41.66  ? 426 LEU   A N   1 
ATOM   249  C CA  . LEU   A 1 53  ? -23.184 -13.401 -6.254  1.00 37.31  ? 426 LEU   A CA  1 
ATOM   250  C C   . LEU   A 1 53  ? -23.919 -12.407 -5.369  1.00 38.21  ? 426 LEU   A C   1 
ATOM   251  O O   . LEU   A 1 53  ? -24.990 -12.725 -4.845  1.00 38.11  ? 426 LEU   A O   1 
ATOM   252  C CB  . LEU   A 1 53  ? -23.937 -13.689 -7.554  1.00 40.40  ? 426 LEU   A CB  1 
ATOM   253  C CG  . LEU   A 1 53  ? -24.361 -12.473 -8.394  1.00 43.04  ? 426 LEU   A CG  1 
ATOM   254  C CD1 . LEU   A 1 53  ? -23.149 -11.804 -9.025  1.00 43.86  ? 426 LEU   A CD1 1 
ATOM   255  C CD2 . LEU   A 1 53  ? -25.383 -12.836 -9.461  1.00 40.36  ? 426 LEU   A CD2 1 
ATOM   256  N N   . ASP   A 1 54  ? -23.345 -11.207 -5.210  1.00 38.61  ? 427 ASP   A N   1 
ATOM   257  C CA  . ASP   A 1 54  ? -24.005 -10.138 -4.470  1.00 40.50  ? 427 ASP   A CA  1 
ATOM   258  C C   . ASP   A 1 54  ? -24.596 -9.108  -5.431  1.00 40.75  ? 427 ASP   A C   1 
ATOM   259  O O   . ASP   A 1 54  ? -24.391 -9.182  -6.633  1.00 39.17  ? 427 ASP   A O   1 
ATOM   260  C CB  . ASP   A 1 54  ? -23.070 -9.487  -3.466  1.00 43.01  ? 427 ASP   A CB  1 
ATOM   261  C CG  . ASP   A 1 54  ? -21.840 -8.812  -4.057  1.00 44.25  ? 427 ASP   A CG  1 
ATOM   262  O OD1 . ASP   A 1 54  ? -21.968 -8.193  -5.134  1.00 42.76  ? 427 ASP   A OD1 1 
ATOM   263  O OD2 . ASP   A 1 54  ? -20.769 -8.904  -3.420  1.00 44.01  ? 427 ASP   A OD2 1 
ATOM   264  N N   . VAL   A 1 55  ? -25.292 -8.116  -4.868  1.00 45.39  ? 428 VAL   A N   1 
ATOM   265  C CA  . VAL   A 1 55  ? -26.036 -7.133  -5.642  1.00 49.43  ? 428 VAL   A CA  1 
ATOM   266  C C   . VAL   A 1 55  ? -25.117 -6.082  -6.278  1.00 53.85  ? 428 VAL   A C   1 
ATOM   267  O O   . VAL   A 1 55  ? -25.592 -5.290  -7.091  1.00 53.37  ? 428 VAL   A O   1 
ATOM   268  C CB  . VAL   A 1 55  ? -27.134 -6.478  -4.773  1.00 46.64  ? 428 VAL   A CB  1 
ATOM   269  C CG1 . VAL   A 1 55  ? -28.220 -7.477  -4.388  1.00 44.77  ? 428 VAL   A CG1 1 
ATOM   270  C CG2 . VAL   A 1 55  ? -26.584 -5.804  -3.525  1.00 45.72  ? 428 VAL   A CG2 1 
ATOM   271  N N   . ASP   A 1 56  ? -23.813 -6.085  -5.950  1.00 51.37  ? 429 ASP   A N   1 
ATOM   272  C CA  . ASP   A 1 56  ? -22.850 -5.225  -6.630  1.00 48.20  ? 429 ASP   A CA  1 
ATOM   273  C C   . ASP   A 1 56  ? -22.169 -5.944  -7.790  1.00 45.70  ? 429 ASP   A C   1 
ATOM   274  O O   . ASP   A 1 56  ? -21.173 -5.456  -8.311  1.00 50.31  ? 429 ASP   A O   1 
ATOM   275  C CB  . ASP   A 1 56  ? -21.767 -4.724  -5.692  1.00 49.28  ? 429 ASP   A CB  1 
ATOM   276  C CG  . ASP   A 1 56  ? -22.225 -3.803  -4.574  1.00 57.94  ? 429 ASP   A CG  1 
ATOM   277  O OD1 . ASP   A 1 56  ? -23.368 -3.275  -4.650  1.00 59.57  ? 429 ASP   A OD1 1 
ATOM   278  O OD2 . ASP   A 1 56  ? -21.433 -3.640  -3.621  1.00 62.29  ? 429 ASP   A OD2 1 
ATOM   279  N N   . GLY   A 1 57  ? -22.675 -7.117  -8.179  1.00 47.38  ? 430 GLY   A N   1 
ATOM   280  C CA  . GLY   A 1 57  ? -22.126 -7.853  -9.310  1.00 46.69  ? 430 GLY   A CA  1 
ATOM   281  C C   . GLY   A 1 57  ? -20.834 -8.605  -8.982  1.00 49.01  ? 430 GLY   A C   1 
ATOM   282  O O   . GLY   A 1 57  ? -20.177 -9.116  -9.890  1.00 51.19  ? 430 GLY   A O   1 
ATOM   283  N N   . VAL   A 1 58  ? -20.482 -8.723  -7.693  1.00 47.85  ? 431 VAL   A N   1 
ATOM   284  C CA  . VAL   A 1 58  ? -19.309 -9.491  -7.306  1.00 49.14  ? 431 VAL   A CA  1 
ATOM   285  C C   . VAL   A 1 58  ? -19.661 -10.982 -7.278  1.00 45.97  ? 431 VAL   A C   1 
ATOM   286  O O   . VAL   A 1 58  ? -20.556 -11.393 -6.547  1.00 42.20  ? 431 VAL   A O   1 
ATOM   287  C CB  . VAL   A 1 58  ? -18.739 -9.051  -5.944  1.00 51.93  ? 431 VAL   A CB  1 
ATOM   288  C CG1 . VAL   A 1 58  ? -17.464 -9.813  -5.615  1.00 52.46  ? 431 VAL   A CG1 1 
ATOM   289  C CG2 . VAL   A 1 58  ? -18.499 -7.544  -5.863  1.00 52.25  ? 431 VAL   A CG2 1 
ATOM   290  N N   . ILE   A 1 59  ? -18.911 -11.773 -8.052  1.00 46.36  ? 432 ILE   A N   1 
ATOM   291  C CA  . ILE   A 1 59  ? -18.991 -13.222 -8.057  1.00 48.77  ? 432 ILE   A CA  1 
ATOM   292  C C   . ILE   A 1 59  ? -17.781 -13.784 -7.319  1.00 50.86  ? 432 ILE   A C   1 
ATOM   293  O O   . ILE   A 1 59  ? -16.644 -13.429 -7.640  1.00 54.27  ? 432 ILE   A O   1 
ATOM   294  C CB  . ILE   A 1 59  ? -19.017 -13.754 -9.500  1.00 55.46  ? 432 ILE   A CB  1 
ATOM   295  C CG1 . ILE   A 1 59  ? -20.102 -13.092 -10.324 1.00 61.32  ? 432 ILE   A CG1 1 
ATOM   296  C CG2 . ILE   A 1 59  ? -19.145 -15.275 -9.517  1.00 58.68  ? 432 ILE   A CG2 1 
ATOM   297  N N   . LYS   A 1 60  ? -18.041 -14.683 -6.359  1.00 47.49  ? 433 LYS   A N   1 
ATOM   298  C CA  . LYS   A 1 60  ? -17.004 -15.387 -5.621  1.00 43.69  ? 433 LYS   A CA  1 
ATOM   299  C C   . LYS   A 1 60  ? -17.204 -16.887 -5.786  1.00 44.62  ? 433 LYS   A C   1 
ATOM   300  O O   . LYS   A 1 60  ? -18.330 -17.382 -5.725  1.00 43.35  ? 433 LYS   A O   1 
ATOM   301  C CB  . LYS   A 1 60  ? -17.070 -15.138 -4.113  1.00 45.70  ? 433 LYS   A CB  1 
ATOM   302  C CG  . LYS   A 1 60  ? -16.981 -13.698 -3.648  1.00 50.94  ? 433 LYS   A CG  1 
ATOM   303  C CD  . LYS   A 1 60  ? -15.558 -13.169 -3.588  1.00 59.79  ? 433 LYS   A CD  1 
ATOM   304  C CE  . LYS   A 1 60  ? -15.501 -11.757 -3.068  1.00 63.34  ? 433 LYS   A CE  1 
ATOM   305  N NZ  . LYS   A 1 60  ? -14.115 -11.360 -2.804  1.00 65.96  ? 433 LYS   A NZ  1 
ATOM   306  N N   . VAL   A 1 61  ? -16.093 -17.599 -5.983  1.00 45.17  ? 434 VAL   A N   1 
ATOM   307  C CA  . VAL   A 1 61  ? -16.085 -19.047 -5.967  1.00 41.78  ? 434 VAL   A CA  1 
ATOM   308  C C   . VAL   A 1 61  ? -15.168 -19.492 -4.832  1.00 44.90  ? 434 VAL   A C   1 
ATOM   309  O O   . VAL   A 1 61  ? -14.059 -18.984 -4.685  1.00 45.77  ? 434 VAL   A O   1 
ATOM   310  C CB  . VAL   A 1 61  ? -15.646 -19.564 -7.344  1.00 43.84  ? 434 VAL   A CB  1 
ATOM   311  C CG1 . VAL   A 1 61  ? -15.600 -21.086 -7.407  1.00 44.33  ? 434 VAL   A CG1 1 
ATOM   312  C CG2 . VAL   A 1 61  ? -16.530 -19.005 -8.448  1.00 44.01  ? 434 VAL   A CG2 1 
ATOM   313  N N   . TRP   A 1 62  ? -15.661 -20.399 -3.980  1.00 48.24  ? 435 TRP   A N   1 
ATOM   314  C CA  . TRP   A 1 62  ? -14.920 -20.753 -2.780  1.00 44.41  ? 435 TRP   A CA  1 
ATOM   315  C C   . TRP   A 1 62  ? -15.205 -22.184 -2.336  1.00 45.10  ? 435 TRP   A C   1 
ATOM   316  O O   . TRP   A 1 62  ? -16.277 -22.722 -2.588  1.00 44.14  ? 435 TRP   A O   1 
ATOM   317  C CB  . TRP   A 1 62  ? -15.207 -19.749 -1.661  1.00 42.03  ? 435 TRP   A CB  1 
ATOM   318  C CG  . TRP   A 1 62  ? -16.656 -19.402 -1.431  1.00 45.09  ? 435 TRP   A CG  1 
ATOM   319  C CD1 . TRP   A 1 62  ? -17.405 -18.534 -2.168  1.00 44.20  ? 435 TRP   A CD1 1 
ATOM   320  C CD2 . TRP   A 1 62  ? -17.500 -19.826 -0.337  1.00 43.34  ? 435 TRP   A CD2 1 
ATOM   321  N NE1 . TRP   A 1 62  ? -18.654 -18.411 -1.629  1.00 45.00  ? 435 TRP   A NE1 1 
ATOM   322  C CE2 . TRP   A 1 62  ? -18.743 -19.182 -0.503  1.00 40.18  ? 435 TRP   A CE2 1 
ATOM   323  C CE3 . TRP   A 1 62  ? -17.338 -20.687 0.749   1.00 43.33  ? 435 TRP   A CE3 1 
ATOM   324  C CZ2 . TRP   A 1 62  ? -19.807 -19.371 0.368   1.00 39.22  ? 435 TRP   A CZ2 1 
ATOM   325  C CZ3 . TRP   A 1 62  ? -18.393 -20.873 1.617   1.00 44.93  ? 435 TRP   A CZ3 1 
ATOM   326  C CH2 . TRP   A 1 62  ? -19.609 -20.214 1.434   1.00 43.11  ? 435 TRP   A CH2 1 
ATOM   327  N N   . SER   A 1 63  ? -14.200 -22.799 -1.699  1.00 49.94  ? 436 SER   A N   1 
ATOM   328  C CA  . SER   A 1 63  ? -14.357 -24.094 -1.052  1.00 47.94  ? 436 SER   A CA  1 
ATOM   329  C C   . SER   A 1 63  ? -14.590 -23.847 0.428   1.00 45.21  ? 436 SER   A C   1 
ATOM   330  O O   . SER   A 1 63  ? -14.407 -22.725 0.903   1.00 44.68  ? 436 SER   A O   1 
ATOM   331  C CB  . SER   A 1 63  ? -13.164 -24.985 -1.265  1.00 51.80  ? 436 SER   A CB  1 
ATOM   332  O OG  . SER   A 1 63  ? -11.994 -24.403 -0.705  1.00 56.17  ? 436 SER   A OG  1 
ATOM   333  N N   . PHE   A 1 64  ? -15.010 -24.893 1.139   1.00 41.36  ? 437 PHE   A N   1 
ATOM   334  C CA  . PHE   A 1 64  ? -15.297 -24.749 2.552   1.00 39.96  ? 437 PHE   A CA  1 
ATOM   335  C C   . PHE   A 1 64  ? -14.892 -25.994 3.337   1.00 39.62  ? 437 PHE   A C   1 
ATOM   336  O O   . PHE   A 1 64  ? -14.925 -25.976 4.565   1.00 40.79  ? 437 PHE   A O   1 
ATOM   337  C CB  . PHE   A 1 64  ? -16.788 -24.455 2.692   1.00 42.47  ? 437 PHE   A CB  1 
ATOM   338  C CG  . PHE   A 1 64  ? -17.694 -25.488 2.046   1.00 46.20  ? 437 PHE   A CG  1 
ATOM   339  C CD1 . PHE   A 1 64  ? -18.094 -25.349 0.722   1.00 48.74  ? 437 PHE   A CD1 1 
ATOM   340  C CD2 . PHE   A 1 64  ? -18.151 -26.586 2.766   1.00 46.28  ? 437 PHE   A CD2 1 
ATOM   341  C CE1 . PHE   A 1 64  ? -18.920 -26.292 0.132   1.00 47.38  ? 437 PHE   A CE1 1 
ATOM   342  C CE2 . PHE   A 1 64  ? -18.986 -27.518 2.176   1.00 45.67  ? 437 PHE   A CE2 1 
ATOM   343  C CZ  . PHE   A 1 64  ? -19.372 -27.368 0.862   1.00 48.77  ? 437 PHE   A CZ  1 
ATOM   344  N N   . ASN   A 1 65  ? -14.571 -27.080 2.630   1.00 35.91  ? 438 ASN   A N   1 
ATOM   345  C CA  . ASN   A 1 65  ? -14.269 -28.342 3.272   1.00 39.34  ? 438 ASN   A CA  1 
ATOM   346  C C   . ASN   A 1 65  ? -12.826 -28.680 2.922   1.00 44.33  ? 438 ASN   A C   1 
ATOM   347  O O   . ASN   A 1 65  ? -12.562 -29.046 1.786   1.00 37.77  ? 438 ASN   A O   1 
ATOM   348  C CB  . ASN   A 1 65  ? -15.220 -29.465 2.860   1.00 42.11  ? 438 ASN   A CB  1 
ATOM   349  C CG  . ASN   A 1 65  ? -14.990 -30.740 3.646   1.00 47.22  ? 438 ASN   A CG  1 
ATOM   350  O OD1 . ASN   A 1 65  ? -14.429 -30.701 4.747   1.00 47.23  ? 438 ASN   A OD1 1 
ATOM   351  N ND2 . ASN   A 1 65  ? -15.424 -31.878 3.120   1.00 46.36  ? 438 ASN   A ND2 1 
ATOM   352  N N   . PRO   A 1 66  ? -11.860 -28.582 3.870   1.00 44.49  ? 439 PRO   A N   1 
ATOM   353  C CA  . PRO   A 1 66  ? -12.162 -28.407 5.293   1.00 43.20  ? 439 PRO   A CA  1 
ATOM   354  C C   . PRO   A 1 66  ? -12.176 -26.998 5.875   1.00 41.07  ? 439 PRO   A C   1 
ATOM   355  O O   . PRO   A 1 66  ? -12.656 -26.817 6.986   1.00 44.80  ? 439 PRO   A O   1 
ATOM   356  C CB  . PRO   A 1 66  ? -10.994 -29.219 5.852   1.00 41.07  ? 439 PRO   A CB  1 
ATOM   357  C CG  . PRO   A 1 66  ? -9.830  -28.754 5.007   1.00 39.95  ? 439 PRO   A CG  1 
ATOM   358  C CD  . PRO   A 1 66  ? -10.415 -28.670 3.607   1.00 42.20  ? 439 PRO   A CD  1 
ATOM   359  N N   . ILE   A 1 67  ? -11.605 -26.026 5.160   1.00 41.16  ? 440 ILE   A N   1 
ATOM   360  C CA  . ILE   A 1 67  ? -11.713 -24.623 5.553   1.00 48.56  ? 440 ILE   A CA  1 
ATOM   361  C C   . ILE   A 1 67  ? -12.301 -23.809 4.398   1.00 48.72  ? 440 ILE   A C   1 
ATOM   362  O O   . ILE   A 1 67  ? -12.286 -24.222 3.234   1.00 42.26  ? 440 ILE   A O   1 
ATOM   363  C CB  . ILE   A 1 67  ? -10.355 -24.020 5.973   1.00 48.70  ? 440 ILE   A CB  1 
ATOM   364  C CG1 . ILE   A 1 67  ? -9.307  -24.195 4.871   1.00 52.02  ? 440 ILE   A CG1 1 
ATOM   365  C CG2 . ILE   A 1 67  ? -9.881  -24.582 7.315   1.00 54.07  ? 440 ILE   A CG2 1 
ATOM   366  C CD1 . ILE   A 1 67  ? -8.101  -23.279 5.011   1.00 55.10  ? 440 ILE   A CD1 1 
ATOM   367  N N   . MET   A 1 68  ? -12.732 -22.594 4.730   1.00 46.78  ? 441 MET   A N   1 
ATOM   368  C CA  . MET   A 1 68  ? -13.113 -21.634 3.714   1.00 46.58  ? 441 MET   A CA  1 
ATOM   369  C C   . MET   A 1 68  ? -11.867 -21.086 3.043   1.00 46.71  ? 441 MET   A C   1 
ATOM   370  O O   . MET   A 1 68  ? -10.939 -20.657 3.720   1.00 50.61  ? 441 MET   A O   1 
ATOM   371  C CB  . MET   A 1 68  ? -13.937 -20.511 4.336   1.00 45.58  ? 441 MET   A CB  1 
ATOM   372  C CG  . MET   A 1 68  ? -15.382 -20.904 4.391   1.00 50.37  ? 441 MET   A CG  1 
ATOM   373  S SD  . MET   A 1 68  ? -16.270 -19.943 5.615   1.00 64.70  ? 441 MET   A SD  1 
ATOM   374  C CE  . MET   A 1 68  ? -17.836 -20.825 5.531   1.00 63.71  ? 441 MET   A CE  1 
ATOM   375  N N   . GLN   A 1 69  ? -11.846 -21.136 1.712   1.00 47.71  ? 442 GLN   A N   1 
ATOM   376  C CA  . GLN   A 1 69  ? -10.910 -20.316 0.971   1.00 53.86  ? 442 GLN   A CA  1 
ATOM   377  C C   . GLN   A 1 69  ? -11.490 -19.983 -0.404  1.00 52.51  ? 442 GLN   A C   1 
ATOM   378  O O   . GLN   A 1 69  ? -12.226 -20.768 -1.007  1.00 47.61  ? 442 GLN   A O   1 
ATOM   379  C CB  . GLN   A 1 69  ? -9.520  -20.960 0.976   1.00 62.76  ? 442 GLN   A CB  1 
ATOM   380  C CG  . GLN   A 1 69  ? -9.172  -21.809 -0.239  1.00 65.44  ? 442 GLN   A CG  1 
ATOM   381  C CD  . GLN   A 1 69  ? -7.710  -22.207 -0.247  1.00 81.47  ? 442 GLN   A CD  1 
ATOM   382  O OE1 . GLN   A 1 69  ? -7.034  -22.210 0.790   1.00 82.08  ? 442 GLN   A OE1 1 
ATOM   383  N NE2 . GLN   A 1 69  ? -7.209  -22.556 -1.424  1.00 85.65  ? 442 GLN   A NE2 1 
ATOM   384  N N   . THR   A 1 70  ? -11.086 -18.807 -0.884  1.00 51.43  ? 443 THR   A N   1 
ATOM   385  C CA  . THR   A 1 70  ? -11.572 -18.216 -2.111  1.00 53.11  ? 443 THR   A CA  1 
ATOM   386  C C   . THR   A 1 70  ? -10.656 -18.654 -3.248  1.00 57.30  ? 443 THR   A C   1 
ATOM   387  O O   . THR   A 1 70  ? -9.434  -18.550 -3.145  1.00 59.38  ? 443 THR   A O   1 
ATOM   388  C CB  . THR   A 1 70  ? -11.618 -16.698 -1.915  1.00 49.33  ? 443 THR   A CB  1 
ATOM   389  O OG1 . THR   A 1 70  ? -12.521 -16.524 -0.830  1.00 49.25  ? 443 THR   A OG1 1 
ATOM   390  C CG2 . THR   A 1 70  ? -12.167 -15.940 -3.107  1.00 49.18  ? 443 THR   A CG2 1 
ATOM   391  N N   . LYS   A 1 71  ? -11.277 -19.158 -4.319  1.00 57.08  ? 444 LYS   A N   1 
ATOM   392  C CA  . LYS   A 1 71  ? -10.560 -19.666 -5.475  1.00 60.09  ? 444 LYS   A CA  1 
ATOM   393  C C   . LYS   A 1 71  ? -10.607 -18.646 -6.607  1.00 62.51  ? 444 LYS   A C   1 
ATOM   394  O O   . LYS   A 1 71  ? -9.742  -18.660 -7.479  1.00 67.64  ? 444 LYS   A O   1 
ATOM   395  C CB  . LYS   A 1 71  ? -11.179 -20.989 -5.936  1.00 60.05  ? 444 LYS   A CB  1 
ATOM   396  C CG  . LYS   A 1 71  ? -11.556 -21.954 -4.815  1.00 67.02  ? 444 LYS   A CG  1 
ATOM   397  C CD  . LYS   A 1 71  ? -10.400 -22.621 -4.075  1.00 73.97  ? 444 LYS   A CD  1 
ATOM   398  C CE  . LYS   A 1 71  ? -10.019 -23.961 -4.642  1.00 82.44  ? 444 LYS   A CE  1 
ATOM   399  N NZ  . LYS   A 1 71  ? -8.994  -24.632 -3.832  1.00 80.37  ? 444 LYS   A NZ  1 
ATOM   400  N N   . ALA   A 1 72  ? -11.641 -17.790 -6.604  1.00 60.81  ? 445 ALA   A N   1 
ATOM   401  C CA  . ALA   A 1 72  ? -11.833 -16.802 -7.652  1.00 53.00  ? 445 ALA   A CA  1 
ATOM   402  C C   . ALA   A 1 72  ? -12.733 -15.679 -7.151  1.00 52.61  ? 445 ALA   A C   1 
ATOM   403  O O   . ALA   A 1 72  ? -13.666 -15.899 -6.378  1.00 52.72  ? 445 ALA   A O   1 
ATOM   404  C CB  . ALA   A 1 72  ? -12.403 -17.460 -8.887  1.00 51.24  ? 445 ALA   A CB  1 
ATOM   405  N N   . SER   A 1 73  ? -12.426 -14.467 -7.605  1.00 53.62  ? 446 SER   A N   1 
ATOM   406  C CA  . SER   A 1 73  ? -13.192 -13.286 -7.262  1.00 54.87  ? 446 SER   A CA  1 
ATOM   407  C C   . SER   A 1 73  ? -13.149 -12.330 -8.445  1.00 64.77  ? 446 SER   A C   1 
ATOM   408  O O   . SER   A 1 73  ? -12.123 -12.242 -9.110  1.00 69.05  ? 446 SER   A O   1 
ATOM   409  C CB  . SER   A 1 73  ? -12.671 -12.641 -6.023  1.00 54.50  ? 446 SER   A CB  1 
ATOM   410  O OG  . SER   A 1 73  ? -13.577 -11.644 -5.573  1.00 61.22  ? 446 SER   A OG  1 
ATOM   411  N N   . SER   A 1 74  ? -14.271 -11.647 -8.712  1.00 71.88  ? 447 SER   A N   1 
ATOM   412  C CA  . SER   A 1 74  ? -14.346 -10.697 -9.812  1.00 74.97  ? 447 SER   A CA  1 
ATOM   413  C C   . SER   A 1 74  ? -15.567 -9.795  -9.662  1.00 77.60  ? 447 SER   A C   1 
ATOM   414  O O   . SER   A 1 74  ? -16.614 -10.239 -9.191  1.00 74.87  ? 447 SER   A O   1 
ATOM   415  C CB  . SER   A 1 74  ? -14.358 -11.392 -11.154 1.00 76.94  ? 447 SER   A CB  1 
ATOM   416  O OG  . SER   A 1 74  ? -15.398 -12.355 -11.228 1.00 76.99  ? 447 SER   A OG  1 
ATOM   417  N N   . ILE   A 1 75  ? -15.388 -8.526  -10.060 1.00 77.15  ? 448 ILE   A N   1 
ATOM   418  C CA  . ILE   A 1 75  ? -16.470 -7.569  -10.228 1.00 70.57  ? 448 ILE   A CA  1 
ATOM   419  C C   . ILE   A 1 75  ? -16.937 -7.660  -11.678 1.00 69.11  ? 448 ILE   A C   1 
ATOM   420  O O   . ILE   A 1 75  ? -16.130 -7.551  -12.596 1.00 68.40  ? 448 ILE   A O   1 
ATOM   421  C CB  . ILE   A 1 75  ? -16.022 -6.133  -9.885  1.00 71.48  ? 448 ILE   A CB  1 
ATOM   422  C CG1 . ILE   A 1 75  ? -14.776 -6.101  -8.981  1.00 72.20  ? 448 ILE   A CG1 1 
ATOM   423  C CG2 . ILE   A 1 75  ? -17.179 -5.330  -9.286  1.00 70.38  ? 448 ILE   A CG2 1 
ATOM   424  N N   . SER   A 1 76  ? -18.236 -7.885  -11.881 1.00 61.57  ? 449 SER   A N   1 
ATOM   425  C CA  . SER   A 1 76  ? -18.825 -7.783  -13.205 1.00 64.63  ? 449 SER   A CA  1 
ATOM   426  C C   . SER   A 1 76  ? -19.052 -6.304  -13.523 1.00 65.43  ? 449 SER   A C   1 
ATOM   427  O O   . SER   A 1 76  ? -19.449 -5.534  -12.647 1.00 60.72  ? 449 SER   A O   1 
ATOM   428  C CB  . SER   A 1 76  ? -20.111 -8.589  -13.279 1.00 61.52  ? 449 SER   A CB  1 
ATOM   429  O OG  . SER   A 1 76  ? -20.627 -8.666  -14.601 1.00 62.33  ? 449 SER   A OG  1 
ATOM   430  N N   . LYS   A 1 77  ? -18.773 -5.904  -14.770 1.00 69.83  ? 450 LYS   A N   1 
ATOM   431  C CA  . LYS   A 1 77  ? -19.109 -4.562  -15.226 1.00 79.04  ? 450 LYS   A CA  1 
ATOM   432  C C   . LYS   A 1 77  ? -20.622 -4.505  -15.441 1.00 78.60  ? 450 LYS   A C   1 
ATOM   433  O O   . LYS   A 1 77  ? -21.302 -3.612  -14.932 1.00 76.46  ? 450 LYS   A O   1 
ATOM   434  C CB  . LYS   A 1 77  ? -18.319 -4.195  -16.489 1.00 80.20  ? 450 LYS   A CB  1 
ATOM   435  N N   . SER   A 1 78  ? -21.127 -5.511  -16.169 1.00 76.03  ? 451 SER   A N   1 
ATOM   436  C CA  . SER   A 1 78  ? -22.551 -5.721  -16.383 1.00 71.05  ? 451 SER   A CA  1 
ATOM   437  C C   . SER   A 1 78  ? -23.229 -6.193  -15.095 1.00 62.16  ? 451 SER   A C   1 
ATOM   438  O O   . SER   A 1 78  ? -22.626 -6.890  -14.283 1.00 56.02  ? 451 SER   A O   1 
ATOM   439  C CB  . SER   A 1 78  ? -22.776 -6.726  -17.488 1.00 72.90  ? 451 SER   A CB  1 
ATOM   440  O OG  . SER   A 1 78  ? -21.913 -6.483  -18.590 1.00 77.76  ? 451 SER   A OG  1 
ATOM   441  N N   . PRO   A 1 79  ? -24.511 -5.841  -14.864 1.00 61.34  ? 452 PRO   A N   1 
ATOM   442  C CA  . PRO   A 1 79  ? -25.286 -6.457  -13.785 1.00 63.05  ? 452 PRO   A CA  1 
ATOM   443  C C   . PRO   A 1 79  ? -25.453 -7.960  -14.021 1.00 53.17  ? 452 PRO   A C   1 
ATOM   444  O O   . PRO   A 1 79  ? -25.654 -8.385  -15.160 1.00 51.94  ? 452 PRO   A O   1 
ATOM   445  C CB  . PRO   A 1 79  ? -26.638 -5.691  -13.801 1.00 62.08  ? 452 PRO   A CB  1 
ATOM   446  C CG  . PRO   A 1 79  ? -26.718 -5.076  -15.191 1.00 64.41  ? 452 PRO   A CG  1 
ATOM   447  C CD  . PRO   A 1 79  ? -25.276 -4.830  -15.616 1.00 64.20  ? 452 PRO   A CD  1 
ATOM   448  N N   . LEU   A 1 80  ? -25.327 -8.757  -12.950 1.00 49.11  ? 453 LEU   A N   1 
ATOM   449  C CA  . LEU   A 1 80  ? -25.513 -10.203 -13.038 1.00 49.61  ? 453 LEU   A CA  1 
ATOM   450  C C   . LEU   A 1 80  ? -26.757 -10.582 -12.250 1.00 44.56  ? 453 LEU   A C   1 
ATOM   451  O O   . LEU   A 1 80  ? -26.904 -10.151 -11.113 1.00 43.45  ? 453 LEU   A O   1 
ATOM   452  C CB  . LEU   A 1 80  ? -24.296 -10.971 -12.540 1.00 47.24  ? 453 LEU   A CB  1 
ATOM   453  C CG  . LEU   A 1 80  ? -23.071 -10.957 -13.460 1.00 48.46  ? 453 LEU   A CG  1 
ATOM   454  C CD1 . LEU   A 1 80  ? -21.941 -11.774 -12.847 1.00 49.58  ? 453 LEU   A CD1 1 
ATOM   455  C CD2 . LEU   A 1 80  ? -23.404 -11.484 -14.838 1.00 50.70  ? 453 LEU   A CD2 1 
ATOM   456  N N   . LEU   A 1 81  ? -27.631 -11.383 -12.870 1.00 42.23  ? 454 LEU   A N   1 
ATOM   457  C CA  . LEU   A 1 81  ? -28.925 -11.719 -12.287 1.00 42.56  ? 454 LEU   A CA  1 
ATOM   458  C C   . LEU   A 1 81  ? -29.043 -13.214 -11.962 1.00 38.44  ? 454 LEU   A C   1 
ATOM   459  O O   . LEU   A 1 81  ? -29.895 -13.604 -11.177 1.00 40.79  ? 454 LEU   A O   1 
ATOM   460  C CB  . LEU   A 1 81  ? -30.019 -11.309 -13.277 1.00 43.44  ? 454 LEU   A CB  1 
ATOM   461  C CG  . LEU   A 1 81  ? -30.076 -9.829  -13.686 1.00 47.17  ? 454 LEU   A CG  1 
ATOM   462  C CD1 . LEU   A 1 81  ? -31.295 -9.581  -14.549 1.00 45.46  ? 454 LEU   A CD1 1 
ATOM   463  C CD2 . LEU   A 1 81  ? -30.104 -8.878  -12.505 1.00 48.52  ? 454 LEU   A CD2 1 
ATOM   464  N N   . SER   A 1 82  ? -28.281 -14.076 -12.642 1.00 36.69  ? 455 SER   A N   1 
ATOM   465  C CA  . SER   A 1 82  ? -28.457 -15.503 -12.454 1.00 36.53  ? 455 SER   A CA  1 
ATOM   466  C C   . SER   A 1 82  ? -27.127 -16.244 -12.569 1.00 35.86  ? 455 SER   A C   1 
ATOM   467  O O   . SER   A 1 82  ? -26.140 -15.751 -13.115 1.00 36.53  ? 455 SER   A O   1 
ATOM   468  C CB  . SER   A 1 82  ? -29.507 -16.060 -13.392 1.00 37.12  ? 455 SER   A CB  1 
ATOM   469  O OG  . SER   A 1 82  ? -29.194 -15.767 -14.747 1.00 35.97  ? 455 SER   A OG  1 
ATOM   470  N N   . LEU   A 1 83  ? -27.140 -17.456 -12.025 1.00 34.83  ? 456 LEU   A N   1 
ATOM   471  C CA  . LEU   A 1 83  ? -25.955 -18.284 -11.866 1.00 36.12  ? 456 LEU   A CA  1 
ATOM   472  C C   . LEU   A 1 83  ? -26.416 -19.736 -11.781 1.00 33.86  ? 456 LEU   A C   1 
ATOM   473  O O   . LEU   A 1 83  ? -27.445 -20.012 -11.161 1.00 34.13  ? 456 LEU   A O   1 
ATOM   474  C CB  . LEU   A 1 83  ? -25.362 -17.715 -10.584 1.00 40.43  ? 456 LEU   A CB  1 
ATOM   475  C CG  . LEU   A 1 83  ? -24.419 -18.575 -9.746  1.00 44.03  ? 456 LEU   A CG  1 
ATOM   476  C CD1 . LEU   A 1 83  ? -23.972 -17.628 -8.641  1.00 41.38  ? 456 LEU   A CD1 1 
ATOM   477  C CD2 . LEU   A 1 83  ? -25.028 -19.842 -9.166  1.00 44.19  ? 456 LEU   A CD2 1 
ATOM   478  N N   . GLU   A 1 84  ? -25.687 -20.634 -12.447 1.00 31.60  ? 457 GLU   A N   1 
ATOM   479  C CA  . GLU   A 1 84  ? -26.025 -22.048 -12.469 1.00 32.21  ? 457 GLU   A CA  1 
ATOM   480  C C   . GLU   A 1 84  ? -24.770 -22.848 -12.794 1.00 33.57  ? 457 GLU   A C   1 
ATOM   481  O O   . GLU   A 1 84  ? -24.095 -22.572 -13.782 1.00 36.82  ? 457 GLU   A O   1 
ATOM   482  C CB  . GLU   A 1 84  ? -27.113 -22.311 -13.511 1.00 31.15  ? 457 GLU   A CB  1 
ATOM   483  C CG  . GLU   A 1 84  ? -27.354 -23.788 -13.811 1.00 34.41  ? 457 GLU   A CG  1 
ATOM   484  C CD  . GLU   A 1 84  ? -28.254 -24.510 -12.817 1.00 33.58  ? 457 GLU   A CD  1 
ATOM   485  O OE1 . GLU   A 1 84  ? -28.485 -23.977 -11.711 1.00 31.74  ? 457 GLU   A OE1 1 
ATOM   486  O OE2 . GLU   A 1 84  ? -28.773 -25.581 -13.205 1.00 31.45  ? 457 GLU   A OE2 1 
ATOM   487  N N   . TRP   A 1 85  ? -24.501 -23.871 -11.982 1.00 34.67  ? 458 TRP   A N   1 
ATOM   488  C CA  . TRP   A 1 85  ? -23.408 -24.802 -12.217 1.00 34.43  ? 458 TRP   A CA  1 
ATOM   489  C C   . TRP   A 1 85  ? -23.742 -25.770 -13.345 1.00 34.18  ? 458 TRP   A C   1 
ATOM   490  O O   . TRP   A 1 85  ? -24.884 -26.194 -13.503 1.00 33.70  ? 458 TRP   A O   1 
ATOM   491  C CB  . TRP   A 1 85  ? -23.092 -25.586 -10.939 1.00 34.08  ? 458 TRP   A CB  1 
ATOM   492  C CG  . TRP   A 1 85  ? -22.428 -24.766 -9.868  1.00 32.00  ? 458 TRP   A CG  1 
ATOM   493  C CD1 . TRP   A 1 85  ? -23.006 -24.220 -8.760  1.00 33.12  ? 458 TRP   A CD1 1 
ATOM   494  C CD2 . TRP   A 1 85  ? -21.035 -24.407 -9.807  1.00 32.56  ? 458 TRP   A CD2 1 
ATOM   495  N NE1 . TRP   A 1 85  ? -22.065 -23.586 -7.994  1.00 31.21  ? 458 TRP   A NE1 1 
ATOM   496  C CE2 . TRP   A 1 85  ? -20.854 -23.666 -8.622  1.00 31.35  ? 458 TRP   A CE2 1 
ATOM   497  C CE3 . TRP   A 1 85  ? -19.933 -24.636 -10.636 1.00 35.20  ? 458 TRP   A CE3 1 
ATOM   498  C CZ2 . TRP   A 1 85  ? -19.614 -23.163 -8.247  1.00 35.98  ? 458 TRP   A CZ2 1 
ATOM   499  C CZ3 . TRP   A 1 85  ? -18.702 -24.147 -10.253 1.00 34.27  ? 458 TRP   A CZ3 1 
ATOM   500  C CH2 . TRP   A 1 85  ? -18.544 -23.439 -9.069  1.00 35.14  ? 458 TRP   A CH2 1 
ATOM   501  N N   . ALA   A 1 86  ? -22.719 -26.107 -14.137 1.00 37.70  ? 459 ALA   A N   1 
ATOM   502  C CA  . ALA   A 1 86  ? -22.825 -27.147 -15.150 1.00 39.72  ? 459 ALA   A CA  1 
ATOM   503  C C   . ALA   A 1 86  ? -22.815 -28.517 -14.476 1.00 37.76  ? 459 ALA   A C   1 
ATOM   504  O O   . ALA   A 1 86  ? -22.252 -28.666 -13.395 1.00 34.95  ? 459 ALA   A O   1 
ATOM   505  C CB  . ALA   A 1 86  ? -21.692 -27.008 -16.139 1.00 43.58  ? 459 ALA   A CB  1 
ATOM   506  N N   . THR   A 1 87  ? -23.465 -29.495 -15.118 1.00 37.89  ? 460 THR   A N   1 
ATOM   507  C CA  . THR   A 1 87  ? -23.718 -30.789 -14.505 1.00 45.10  ? 460 THR   A CA  1 
ATOM   508  C C   . THR   A 1 87  ? -22.664 -31.842 -14.872 1.00 47.36  ? 460 THR   A C   1 
ATOM   509  O O   . THR   A 1 87  ? -22.590 -32.861 -14.185 1.00 47.24  ? 460 THR   A O   1 
ATOM   510  C CB  . THR   A 1 87  ? -25.112 -31.274 -14.906 1.00 46.40  ? 460 THR   A CB  1 
ATOM   511  O OG1 . THR   A 1 87  ? -25.165 -31.098 -16.316 1.00 44.52  ? 460 THR   A OG1 1 
ATOM   512  C CG2 . THR   A 1 87  ? -26.214 -30.495 -14.211 1.00 47.29  ? 460 THR   A CG2 1 
ATOM   513  N N   . LYS   A 1 88  ? -21.920 -31.652 -15.975 1.00 44.45  ? 461 LYS   A N   1 
ATOM   514  C CA  . LYS   A 1 88  ? -20.988 -32.673 -16.440 1.00 49.77  ? 461 LYS   A CA  1 
ATOM   515  C C   . LYS   A 1 88  ? -19.550 -32.164 -16.496 1.00 50.07  ? 461 LYS   A C   1 
ATOM   516  O O   . LYS   A 1 88  ? -18.676 -32.866 -16.982 1.00 62.08  ? 461 LYS   A O   1 
ATOM   517  C CB  . LYS   A 1 88  ? -21.395 -33.264 -17.795 1.00 52.01  ? 461 LYS   A CB  1 
ATOM   518  C CG  . LYS   A 1 88  ? -22.676 -34.094 -17.778 1.00 53.40  ? 461 LYS   A CG  1 
ATOM   519  C CD  . LYS   A 1 88  ? -22.659 -35.262 -16.795 1.00 56.80  ? 461 LYS   A CD  1 
ATOM   520  C CE  . LYS   A 1 88  ? -23.781 -36.212 -17.076 1.00 58.96  ? 461 LYS   A CE  1 
ATOM   521  N NZ  . LYS   A 1 88  ? -23.778 -37.365 -16.175 1.00 61.10  ? 461 LYS   A NZ  1 
ATOM   522  N N   A ARG   A 1 89  ? -19.313 -30.941 -16.014 0.50 52.94  ? 462 ARG   A N   1 
ATOM   523  N N   B ARG   A 1 89  ? -19.320 -30.968 -15.951 0.50 51.94  ? 462 ARG   A N   1 
ATOM   524  C CA  A ARG   A 1 89  ? -17.967 -30.446 -15.784 0.50 52.47  ? 462 ARG   A CA  1 
ATOM   525  C CA  B ARG   A 1 89  ? -17.989 -30.411 -15.806 0.50 50.70  ? 462 ARG   A CA  1 
ATOM   526  C C   A ARG   A 1 89  ? -18.027 -29.490 -14.600 0.50 52.35  ? 462 ARG   A C   1 
ATOM   527  C C   B ARG   A 1 89  ? -18.016 -29.475 -14.601 0.50 51.41  ? 462 ARG   A C   1 
ATOM   528  O O   A ARG   A 1 89  ? -18.356 -28.314 -14.751 0.50 51.33  ? 462 ARG   A O   1 
ATOM   529  O O   B ARG   A 1 89  ? -18.319 -28.289 -14.737 0.50 50.48  ? 462 ARG   A O   1 
ATOM   530  C CB  A ARG   A 1 89  ? -17.350 -29.787 -17.025 0.50 57.17  ? 462 ARG   A CB  1 
ATOM   531  C CB  B ARG   A 1 89  ? -17.553 -29.753 -17.123 0.50 53.54  ? 462 ARG   A CB  1 
ATOM   532  C CG  A ARG   A 1 89  ? -15.877 -29.418 -16.878 0.50 58.81  ? 462 ARG   A CG  1 
ATOM   533  C CG  B ARG   A 1 89  ? -16.871 -30.693 -18.112 0.50 54.92  ? 462 ARG   A CG  1 
ATOM   534  C CD  A ARG   A 1 89  ? -15.246 -29.136 -18.240 0.50 61.06  ? 462 ARG   A CD  1 
ATOM   535  C CD  B ARG   A 1 89  ? -16.238 -29.983 -19.311 0.50 54.43  ? 462 ARG   A CD  1 
ATOM   536  N NE  A ARG   A 1 89  ? -13.884 -28.594 -18.185 0.50 61.59  ? 462 ARG   A NE  1 
ATOM   537  N NE  B ARG   A 1 89  ? -16.777 -30.399 -20.610 0.50 53.71  ? 462 ARG   A NE  1 
ATOM   538  C CZ  A ARG   A 1 89  ? -12.823 -29.227 -17.702 0.50 61.21  ? 462 ARG   A CZ  1 
ATOM   539  C CZ  B ARG   A 1 89  ? -16.386 -29.898 -21.777 0.50 58.28  ? 462 ARG   A CZ  1 
ATOM   540  N NH1 A ARG   A 1 89  ? -12.940 -30.448 -17.212 0.50 60.62  ? 462 ARG   A NH1 1 
ATOM   541  N NH1 B ARG   A 1 89  ? -15.574 -28.854 -21.804 0.50 59.53  ? 462 ARG   A NH1 1 
ATOM   542  N NH2 A ARG   A 1 89  ? -11.647 -28.629 -17.711 0.50 60.37  ? 462 ARG   A NH2 1 
ATOM   543  N NH2 B ARG   A 1 89  ? -16.824 -30.420 -22.910 0.50 56.35  ? 462 ARG   A NH2 1 
ATOM   544  N N   . ASP   A 1 90  ? -17.699 -30.036 -13.426 1.00 54.23  ? 463 ASP   A N   1 
ATOM   545  C CA  . ASP   A 1 90  ? -17.874 -29.373 -12.142 1.00 58.21  ? 463 ASP   A CA  1 
ATOM   546  C C   . ASP   A 1 90  ? -17.405 -27.922 -12.164 1.00 55.56  ? 463 ASP   A C   1 
ATOM   547  O O   . ASP   A 1 90  ? -18.010 -27.086 -11.491 1.00 54.83  ? 463 ASP   A O   1 
ATOM   548  C CB  . ASP   A 1 90  ? -17.146 -30.122 -11.032 1.00 58.60  ? 463 ASP   A CB  1 
ATOM   549  C CG  . ASP   A 1 90  ? -17.710 -31.490 -10.666 1.00 65.46  ? 463 ASP   A CG  1 
ATOM   550  O OD1 . ASP   A 1 90  ? -18.847 -31.805 -11.095 1.00 67.80  ? 463 ASP   A OD1 1 
ATOM   551  O OD2 . ASP   A 1 90  ? -17.000 -32.237 -9.953  1.00 71.44  ? 463 ASP   A OD2 1 
ATOM   552  N N   . ARG   A 1 91  ? -16.322 -27.654 -12.912 1.00 45.51  ? 464 ARG   A N   1 
ATOM   553  C CA  . ARG   A 1 91  ? -15.624 -26.383 -12.854 1.00 44.33  ? 464 ARG   A CA  1 
ATOM   554  C C   . ARG   A 1 91  ? -16.366 -25.273 -13.610 1.00 44.25  ? 464 ARG   A C   1 
ATOM   555  O O   . ARG   A 1 91  ? -16.021 -24.104 -13.443 1.00 42.57  ? 464 ARG   A O   1 
ATOM   556  C CB  . ARG   A 1 91  ? -14.218 -26.587 -13.438 1.00 50.11  ? 464 ARG   A CB  1 
ATOM   557  N N   . LEU   A 1 92  ? -17.340 -25.625 -14.468 1.00 38.53  ? 465 LEU   A N   1 
ATOM   558  C CA  . LEU   A 1 92  ? -17.982 -24.648 -15.340 1.00 39.92  ? 465 LEU   A CA  1 
ATOM   559  C C   . LEU   A 1 92  ? -19.210 -24.034 -14.663 1.00 40.81  ? 465 LEU   A C   1 
ATOM   560  O O   . LEU   A 1 92  ? -20.039 -24.739 -14.097 1.00 41.57  ? 465 LEU   A O   1 
ATOM   561  C CB  . LEU   A 1 92  ? -18.395 -25.263 -16.676 1.00 41.64  ? 465 LEU   A CB  1 
ATOM   562  C CG  . LEU   A 1 92  ? -17.271 -25.795 -17.566 1.00 49.55  ? 465 LEU   A CG  1 
ATOM   563  C CD1 . LEU   A 1 92  ? -17.794 -26.183 -18.950 1.00 49.39  ? 465 LEU   A CD1 1 
ATOM   564  C CD2 . LEU   A 1 92  ? -16.148 -24.782 -17.670 1.00 51.15  ? 465 LEU   A CD2 1 
ATOM   565  N N   . LEU   A 1 93  ? -19.341 -22.714 -14.810 1.00 39.83  ? 466 LEU   A N   1 
ATOM   566  C CA  . LEU   A 1 93  ? -20.414 -21.938 -14.224 1.00 38.74  ? 466 LEU   A CA  1 
ATOM   567  C C   . LEU   A 1 93  ? -21.079 -21.092 -15.306 1.00 40.18  ? 466 LEU   A C   1 
ATOM   568  O O   . LEU   A 1 93  ? -20.408 -20.319 -15.977 1.00 37.53  ? 466 LEU   A O   1 
ATOM   569  C CB  . LEU   A 1 93  ? -19.801 -21.054 -13.143 1.00 37.61  ? 466 LEU   A CB  1 
ATOM   570  C CG  . LEU   A 1 93  ? -20.798 -20.233 -12.329 1.00 42.04  ? 466 LEU   A CG  1 
ATOM   571  C CD1 . LEU   A 1 93  ? -21.748 -21.172 -11.589 1.00 43.87  ? 466 LEU   A CD1 1 
ATOM   572  C CD2 . LEU   A 1 93  ? -20.102 -19.309 -11.368 1.00 41.23  ? 466 LEU   A CD2 1 
ATOM   573  N N   . LEU   A 1 94  ? -22.403 -21.220 -15.450 1.00 38.59  ? 467 LEU   A N   1 
ATOM   574  C CA  . LEU   A 1 94  ? -23.172 -20.327 -16.298 1.00 32.01  ? 467 LEU   A CA  1 
ATOM   575  C C   . LEU   A 1 94  ? -23.566 -19.090 -15.497 1.00 36.76  ? 467 LEU   A C   1 
ATOM   576  O O   . LEU   A 1 94  ? -23.974 -19.187 -14.340 1.00 34.51  ? 467 LEU   A O   1 
ATOM   577  C CB  . LEU   A 1 94  ? -24.411 -21.027 -16.839 1.00 32.87  ? 467 LEU   A CB  1 
ATOM   578  C CG  . LEU   A 1 94  ? -24.188 -22.192 -17.800 1.00 35.21  ? 467 LEU   A CG  1 
ATOM   579  C CD1 . LEU   A 1 94  ? -25.452 -23.027 -17.916 1.00 39.46  ? 467 LEU   A CD1 1 
ATOM   580  C CD2 . LEU   A 1 94  ? -23.796 -21.639 -19.160 1.00 37.63  ? 467 LEU   A CD2 1 
ATOM   581  N N   . LEU   A 1 95  ? -23.481 -17.927 -16.151 1.00 37.92  ? 468 LEU   A N   1 
ATOM   582  C CA  . LEU   A 1 95  ? -23.860 -16.658 -15.555 1.00 40.43  ? 468 LEU   A CA  1 
ATOM   583  C C   . LEU   A 1 95  ? -24.773 -15.902 -16.512 1.00 41.20  ? 468 LEU   A C   1 
ATOM   584  O O   . LEU   A 1 95  ? -24.476 -15.795 -17.698 1.00 42.10  ? 468 LEU   A O   1 
ATOM   585  C CB  . LEU   A 1 95  ? -22.589 -15.874 -15.259 1.00 42.11  ? 468 LEU   A CB  1 
ATOM   586  C CG  . LEU   A 1 95  ? -21.662 -16.504 -14.216 1.00 44.96  ? 468 LEU   A CG  1 
ATOM   587  C CD1 . LEU   A 1 95  ? -20.303 -15.845 -14.238 1.00 46.16  ? 468 LEU   A CD1 1 
ATOM   588  C CD2 . LEU   A 1 95  ? -22.274 -16.397 -12.838 1.00 46.59  ? 468 LEU   A CD2 1 
ATOM   589  N N   . GLY   A 1 96  ? -25.900 -15.407 -15.989 1.00 42.99  ? 469 GLY   A N   1 
ATOM   590  C CA  . GLY   A 1 96  ? -26.844 -14.629 -16.774 1.00 41.92  ? 469 GLY   A CA  1 
ATOM   591  C C   . GLY   A 1 96  ? -26.801 -13.172 -16.327 1.00 43.67  ? 469 GLY   A C   1 
ATOM   592  O O   . GLY   A 1 96  ? -26.799 -12.889 -15.125 1.00 43.66  ? 469 GLY   A O   1 
ATOM   593  N N   . SER   A 1 97  ? -26.739 -12.264 -17.313 1.00 45.34  ? 470 SER   A N   1 
ATOM   594  C CA  . SER   A 1 97  ? -26.569 -10.842 -17.052 1.00 45.45  ? 470 SER   A CA  1 
ATOM   595  C C   . SER   A 1 97  ? -27.917 -10.135 -17.112 1.00 41.77  ? 470 SER   A C   1 
ATOM   596  O O   . SER   A 1 97  ? -28.905 -10.709 -17.557 1.00 36.62  ? 470 SER   A O   1 
ATOM   597  C CB  . SER   A 1 97  ? -25.620 -10.214 -18.050 1.00 46.71  ? 470 SER   A CB  1 
ATOM   598  O OG  . SER   A 1 97  ? -26.260 -10.028 -19.304 1.00 42.30  ? 470 SER   A OG  1 
ATOM   599  N N   . GLY   A 1 98  ? -27.905 -8.863  -16.701 1.00 46.30  ? 471 GLY   A N   1 
ATOM   600  C CA  . GLY   A 1 98  ? -28.987 -7.927  -16.955 1.00 43.93  ? 471 GLY   A CA  1 
ATOM   601  C C   . GLY   A 1 98  ? -28.816 -7.174  -18.280 1.00 47.22  ? 471 GLY   A C   1 
ATOM   602  O O   . GLY   A 1 98  ? -29.509 -6.184  -18.495 1.00 45.73  ? 471 GLY   A O   1 
ATOM   603  N N   . VAL   A 1 99  ? -27.923 -7.646  -19.169 1.00 47.61  ? 472 VAL   A N   1 
ATOM   604  C CA  . VAL   A 1 99  ? -27.716 -7.009  -20.465 1.00 49.36  ? 472 VAL   A CA  1 
ATOM   605  C C   . VAL   A 1 99  ? -27.832 -8.050  -21.569 1.00 50.06  ? 472 VAL   A C   1 
ATOM   606  O O   . VAL   A 1 99  ? -27.156 -7.940  -22.589 1.00 48.76  ? 472 VAL   A O   1 
ATOM   607  C CB  . VAL   A 1 99  ? -26.371 -6.263  -20.590 1.00 48.25  ? 472 VAL   A CB  1 
ATOM   608  C CG1 . VAL   A 1 99  ? -26.311 -5.077  -19.637 1.00 48.95  ? 472 VAL   A CG1 1 
ATOM   609  C CG2 . VAL   A 1 99  ? -25.155 -7.181  -20.420 1.00 45.56  ? 472 VAL   A CG2 1 
ATOM   610  N N   . GLY   A 1 100 ? -28.661 -9.074  -21.346 1.00 47.69  ? 473 GLY   A N   1 
ATOM   611  C CA  . GLY   A 1 100 ? -29.024 -9.985  -22.413 1.00 43.64  ? 473 GLY   A CA  1 
ATOM   612  C C   . GLY   A 1 100 ? -27.885 -10.914 -22.822 1.00 45.30  ? 473 GLY   A C   1 
ATOM   613  O O   . GLY   A 1 100 ? -27.854 -11.371 -23.966 1.00 43.97  ? 473 GLY   A O   1 
ATOM   614  N N   . THR   A 1 101 ? -26.978 -11.243 -21.890 1.00 44.28  ? 474 THR   A N   1 
ATOM   615  C CA  . THR   A 1 101 ? -25.898 -12.172 -22.215 1.00 44.53  ? 474 THR   A CA  1 
ATOM   616  C C   . THR   A 1 101 ? -25.896 -13.356 -21.255 1.00 42.49  ? 474 THR   A C   1 
ATOM   617  O O   . THR   A 1 101 ? -26.247 -13.221 -20.088 1.00 38.03  ? 474 THR   A O   1 
ATOM   618  C CB  . THR   A 1 101 ? -24.546 -11.461 -22.173 1.00 45.58  ? 474 THR   A CB  1 
ATOM   619  O OG1 . THR   A 1 101 ? -24.469 -10.964 -20.843 1.00 41.50  ? 474 THR   A OG1 1 
ATOM   620  C CG2 . THR   A 1 101 ? -24.457 -10.317 -23.172 1.00 48.33  ? 474 THR   A CG2 1 
ATOM   621  N N   . VAL   A 1 102 ? -25.455 -14.504 -21.778 1.00 47.40  ? 475 VAL   A N   1 
ATOM   622  C CA  . VAL   A 1 102 ? -25.096 -15.661 -20.977 1.00 48.75  ? 475 VAL   A CA  1 
ATOM   623  C C   . VAL   A 1 102 ? -23.607 -15.904 -21.179 1.00 50.19  ? 475 VAL   A C   1 
ATOM   624  O O   . VAL   A 1 102 ? -23.159 -15.986 -22.316 1.00 50.99  ? 475 VAL   A O   1 
ATOM   625  C CB  . VAL   A 1 102 ? -25.898 -16.911 -21.389 1.00 46.36  ? 475 VAL   A CB  1 
ATOM   626  C CG1 . VAL   A 1 102 ? -25.395 -18.167 -20.693 1.00 42.81  ? 475 VAL   A CG1 1 
ATOM   627  C CG2 . VAL   A 1 102 ? -27.395 -16.715 -21.174 1.00 48.71  ? 475 VAL   A CG2 1 
ATOM   628  N N   A ARG   A 1 103 ? -22.857 -16.041 -20.079 0.50 51.71  ? 476 ARG   A N   1 
ATOM   629  N N   B ARG   A 1 103 ? -22.854 -16.029 -20.082 0.50 51.04  ? 476 ARG   A N   1 
ATOM   630  C CA  A ARG   A 1 103 ? -21.434 -16.309 -20.177 0.50 51.46  ? 476 ARG   A CA  1 
ATOM   631  C CA  B ARG   A 1 103 ? -21.435 -16.317 -20.190 0.50 50.27  ? 476 ARG   A CA  1 
ATOM   632  C C   A ARG   A 1 103 ? -21.130 -17.630 -19.475 0.50 50.13  ? 476 ARG   A C   1 
ATOM   633  C C   B ARG   A 1 103 ? -21.131 -17.631 -19.477 0.50 49.55  ? 476 ARG   A C   1 
ATOM   634  O O   A ARG   A 1 103 ? -21.757 -17.975 -18.475 0.50 52.15  ? 476 ARG   A O   1 
ATOM   635  O O   B ARG   A 1 103 ? -21.758 -17.972 -18.475 0.50 51.64  ? 476 ARG   A O   1 
ATOM   636  C CB  A ARG   A 1 103 ? -20.608 -15.118 -19.672 0.50 52.49  ? 476 ARG   A CB  1 
ATOM   637  C CB  B ARG   A 1 103 ? -20.581 -15.126 -19.737 0.50 50.28  ? 476 ARG   A CB  1 
ATOM   638  C CG  A ARG   A 1 103 ? -19.940 -15.252 -18.311 0.50 54.07  ? 476 ARG   A CG  1 
ATOM   639  C CG  B ARG   A 1 103 ? -20.818 -14.584 -18.336 0.50 50.32  ? 476 ARG   A CG  1 
ATOM   640  C CD  A ARG   A 1 103 ? -19.078 -14.033 -17.981 0.50 53.52  ? 476 ARG   A CD  1 
ATOM   641  C CD  B ARG   A 1 103 ? -19.904 -13.394 -18.036 0.50 49.36  ? 476 ARG   A CD  1 
ATOM   642  N NE  A ARG   A 1 103 ? -18.255 -14.230 -16.780 0.50 51.43  ? 476 ARG   A NE  1 
ATOM   643  N NE  B ARG   A 1 103 ? -20.457 -12.144 -18.560 0.50 47.08  ? 476 ARG   A NE  1 
ATOM   644  C CZ  A ARG   A 1 103 ? -18.091 -13.321 -15.830 0.50 47.99  ? 476 ARG   A CZ  1 
ATOM   645  C CZ  B ARG   A 1 103 ? -20.586 -11.018 -17.875 0.50 47.25  ? 476 ARG   A CZ  1 
ATOM   646  N NH1 A ARG   A 1 103 ? -18.611 -12.119 -15.989 0.50 49.05  ? 476 ARG   A NH1 1 
ATOM   647  N NH1 B ARG   A 1 103 ? -21.180 -9.977  -18.431 0.50 49.04  ? 476 ARG   A NH1 1 
ATOM   648  N NH2 A ARG   A 1 103 ? -17.402 -13.605 -14.741 0.50 45.41  ? 476 ARG   A NH2 1 
ATOM   649  N NH2 B ARG   A 1 103 ? -20.133 -10.930 -16.640 0.50 45.81  ? 476 ARG   A NH2 1 
ATOM   650  N N   . LEU   A 1 104 ? -20.192 -18.381 -20.059 1.00 44.88  ? 477 LEU   A N   1 
ATOM   651  C CA  . LEU   A 1 104 ? -19.676 -19.597 -19.473 1.00 44.07  ? 477 LEU   A CA  1 
ATOM   652  C C   . LEU   A 1 104 ? -18.328 -19.259 -18.838 1.00 49.84  ? 477 LEU   A C   1 
ATOM   653  O O   . LEU   A 1 104 ? -17.427 -18.783 -19.518 1.00 51.33  ? 477 LEU   A O   1 
ATOM   654  C CB  . LEU   A 1 104 ? -19.570 -20.609 -20.604 1.00 42.24  ? 477 LEU   A CB  1 
ATOM   655  C CG  . LEU   A 1 104 ? -19.232 -22.046 -20.202 1.00 48.52  ? 477 LEU   A CG  1 
ATOM   656  C CD1 . LEU   A 1 104 ? -20.219 -22.657 -19.199 1.00 47.45  ? 477 LEU   A CD1 1 
ATOM   657  C CD2 . LEU   A 1 104 ? -19.184 -22.892 -21.468 1.00 48.02  ? 477 LEU   A CD2 1 
ATOM   658  N N   . TYR   A 1 105 ? -18.229 -19.458 -17.522 1.00 48.14  ? 478 TYR   A N   1 
ATOM   659  C CA  . TYR   A 1 105 ? -17.042 -19.137 -16.751 1.00 50.53  ? 478 TYR   A CA  1 
ATOM   660  C C   . TYR   A 1 105 ? -16.377 -20.430 -16.285 1.00 53.76  ? 478 TYR   A C   1 
ATOM   661  O O   . TYR   A 1 105 ? -17.027 -21.283 -15.672 1.00 49.88  ? 478 TYR   A O   1 
ATOM   662  C CB  . TYR   A 1 105 ? -17.502 -18.233 -15.606 1.00 50.46  ? 478 TYR   A CB  1 
ATOM   663  C CG  . TYR   A 1 105 ? -16.393 -17.742 -14.691 1.00 55.64  ? 478 TYR   A CG  1 
ATOM   664  C CD1 . TYR   A 1 105 ? -15.411 -16.872 -15.153 1.00 58.49  ? 478 TYR   A CD1 1 
ATOM   665  C CD2 . TYR   A 1 105 ? -16.342 -18.123 -13.358 1.00 62.51  ? 478 TYR   A CD2 1 
ATOM   666  C CE1 . TYR   A 1 105 ? -14.401 -16.414 -14.324 1.00 58.52  ? 478 TYR   A CE1 1 
ATOM   667  C CE2 . TYR   A 1 105 ? -15.338 -17.672 -12.517 1.00 67.04  ? 478 TYR   A CE2 1 
ATOM   668  C CZ  . TYR   A 1 105 ? -14.363 -16.816 -13.001 1.00 68.62  ? 478 TYR   A CZ  1 
ATOM   669  O OH  . TYR   A 1 105 ? -13.385 -16.365 -12.160 1.00 73.16  ? 478 TYR   A OH  1 
ATOM   670  N N   . ASP   A 1 106 ? -15.082 -20.569 -16.605 1.00 51.69  ? 479 ASP   A N   1 
ATOM   671  C CA  . ASP   A 1 106 ? -14.261 -21.649 -16.085 1.00 56.01  ? 479 ASP   A CA  1 
ATOM   672  C C   . ASP   A 1 106 ? -13.680 -21.198 -14.744 1.00 53.43  ? 479 ASP   A C   1 
ATOM   673  O O   . ASP   A 1 106 ? -12.883 -20.266 -14.702 1.00 56.92  ? 479 ASP   A O   1 
ATOM   674  C CB  . ASP   A 1 106 ? -13.174 -22.058 -17.071 1.00 56.77  ? 479 ASP   A CB  1 
ATOM   675  C CG  . ASP   A 1 106 ? -12.358 -23.277 -16.660 1.00 57.16  ? 479 ASP   A CG  1 
ATOM   676  O OD1 . ASP   A 1 106 ? -12.027 -23.376 -15.466 1.00 58.97  ? 479 ASP   A OD1 1 
ATOM   677  O OD2 . ASP   A 1 106 ? -12.063 -24.122 -17.529 1.00 57.67  ? 479 ASP   A OD2 1 
ATOM   678  N N   . THR   A 1 107 ? -14.088 -21.861 -13.652 1.00 50.30  ? 480 THR   A N   1 
ATOM   679  C CA  . THR   A 1 107 ? -13.717 -21.429 -12.312 1.00 51.67  ? 480 THR   A CA  1 
ATOM   680  C C   . THR   A 1 107 ? -12.305 -21.911 -11.977 1.00 53.44  ? 480 THR   A C   1 
ATOM   681  O O   . THR   A 1 107 ? -11.700 -21.380 -11.052 1.00 56.04  ? 480 THR   A O   1 
ATOM   682  C CB  . THR   A 1 107 ? -14.727 -21.943 -11.284 1.00 47.38  ? 480 THR   A CB  1 
ATOM   683  O OG1 . THR   A 1 107 ? -14.803 -23.349 -11.506 1.00 49.50  ? 480 THR   A OG1 1 
ATOM   684  C CG2 . THR   A 1 107 ? -16.101 -21.329 -11.454 1.00 45.29  ? 480 THR   A CG2 1 
ATOM   685  N N   . GLU   A 1 108 ? -11.806 -22.935 -12.689 1.00 57.10  ? 481 GLU   A N   1 
ATOM   686  C CA  . GLU   A 1 108 ? -10.438 -23.411 -12.503 1.00 62.88  ? 481 GLU   A CA  1 
ATOM   687  C C   . GLU   A 1 108 ? -9.484  -22.433 -13.190 1.00 62.20  ? 481 GLU   A C   1 
ATOM   688  O O   . GLU   A 1 108 ? -8.658  -21.809 -12.532 1.00 67.84  ? 481 GLU   A O   1 
ATOM   689  C CB  . GLU   A 1 108 ? -10.244 -24.855 -12.981 1.00 63.31  ? 481 GLU   A CB  1 
ATOM   690  C CG  . GLU   A 1 108 ? -9.585  -25.756 -11.935 1.00 67.34  ? 481 GLU   A CG  1 
ATOM   691  N N   . ALA   A 1 109 ? -9.664  -22.257 -14.504 1.00 65.82  ? 482 ALA   A N   1 
ATOM   692  C CA  . ALA   A 1 109 ? -8.843  -21.370 -15.315 1.00 65.66  ? 482 ALA   A CA  1 
ATOM   693  C C   . ALA   A 1 109 ? -9.109  -19.892 -15.017 1.00 64.55  ? 482 ALA   A C   1 
ATOM   694  O O   . ALA   A 1 109 ? -8.312  -19.046 -15.410 1.00 68.46  ? 482 ALA   A O   1 
ATOM   695  C CB  . ALA   A 1 109 ? -9.077  -21.677 -16.779 1.00 67.04  ? 482 ALA   A CB  1 
ATOM   696  N N   . LYS   A 1 110 ? -10.232 -19.571 -14.357 1.00 67.27  ? 483 LYS   A N   1 
ATOM   697  C CA  . LYS   A 1 110 ? -10.552 -18.202 -13.972 1.00 68.56  ? 483 LYS   A CA  1 
ATOM   698  C C   . LYS   A 1 110 ? -10.637 -17.285 -15.195 1.00 71.71  ? 483 LYS   A C   1 
ATOM   699  O O   . LYS   A 1 110 ? -10.013 -16.229 -15.230 1.00 71.21  ? 483 LYS   A O   1 
ATOM   700  C CB  . LYS   A 1 110 ? -9.542  -17.683 -12.939 1.00 70.66  ? 483 LYS   A CB  1 
ATOM   701  C CG  . LYS   A 1 110 ? -9.825  -18.119 -11.510 1.00 77.80  ? 483 LYS   A CG  1 
ATOM   702  C CD  . LYS   A 1 110 ? -8.655  -17.976 -10.543 1.00 82.96  ? 483 LYS   A CD  1 
ATOM   703  C CE  . LYS   A 1 110 ? -7.767  -19.183 -10.557 1.00 89.80  ? 483 LYS   A CE  1 
ATOM   704  N NZ  . LYS   A 1 110 ? -6.938  -19.254 -9.351  1.00 95.76  ? 483 LYS   A NZ  1 
ATOM   705  N N   . LYS   A 1 111 ? -11.439 -17.683 -16.190 1.00 73.74  ? 484 LYS   A N   1 
ATOM   706  C CA  . LYS   A 1 111 ? -11.666 -16.864 -17.373 1.00 74.34  ? 484 LYS   A CA  1 
ATOM   707  C C   . LYS   A 1 111 ? -12.942 -17.324 -18.077 1.00 67.56  ? 484 LYS   A C   1 
ATOM   708  O O   . LYS   A 1 111 ? -13.351 -18.480 -17.948 1.00 56.40  ? 484 LYS   A O   1 
ATOM   709  C CB  . LYS   A 1 111 ? -10.467 -16.918 -18.332 1.00 81.47  ? 484 LYS   A CB  1 
ATOM   710  C CG  . LYS   A 1 111 ? -10.014 -18.314 -18.784 1.00 86.40  ? 484 LYS   A CG  1 
ATOM   711  C CD  . LYS   A 1 111 ? -9.035  -18.345 -19.957 1.00 86.51  ? 484 LYS   A CD  1 
ATOM   712  N N   . ASN   A 1 112 ? -13.551 -16.406 -18.837 1.00 61.16  ? 485 ASN   A N   1 
ATOM   713  C CA  . ASN   A 1 112 ? -14.751 -16.701 -19.604 1.00 63.03  ? 485 ASN   A CA  1 
ATOM   714  C C   . ASN   A 1 112 ? -14.407 -17.513 -20.850 1.00 58.65  ? 485 ASN   A C   1 
ATOM   715  O O   . ASN   A 1 112 ? -13.626 -17.062 -21.678 1.00 64.95  ? 485 ASN   A O   1 
ATOM   716  C CB  . ASN   A 1 112 ? -15.478 -15.421 -19.991 1.00 62.58  ? 485 ASN   A CB  1 
ATOM   717  C CG  . ASN   A 1 112 ? -15.870 -14.626 -18.771 1.00 67.49  ? 485 ASN   A CG  1 
ATOM   718  O OD1 . ASN   A 1 112 ? -16.598 -15.127 -17.905 1.00 72.86  ? 485 ASN   A OD1 1 
ATOM   719  N ND2 . ASN   A 1 112 ? -15.379 -13.402 -18.661 1.00 71.03  ? 485 ASN   A ND2 1 
ATOM   720  N N   . LEU   A 1 113 ? -15.011 -18.700 -20.986 1.00 55.32  ? 486 LEU   A N   1 
ATOM   721  C CA  . LEU   A 1 113 ? -14.860 -19.520 -22.176 1.00 54.13  ? 486 LEU   A CA  1 
ATOM   722  C C   . LEU   A 1 113 ? -15.666 -18.934 -23.334 1.00 60.02  ? 486 LEU   A C   1 
ATOM   723  O O   . LEU   A 1 113 ? -15.236 -19.024 -24.479 1.00 62.04  ? 486 LEU   A O   1 
ATOM   724  C CB  . LEU   A 1 113 ? -15.265 -20.969 -21.925 1.00 53.83  ? 486 LEU   A CB  1 
ATOM   725  C CG  . LEU   A 1 113 ? -14.548 -21.667 -20.769 1.00 56.99  ? 486 LEU   A CG  1 
ATOM   726  C CD1 . LEU   A 1 113 ? -14.816 -23.163 -20.799 1.00 53.70  ? 486 LEU   A CD1 1 
ATOM   727  C CD2 . LEU   A 1 113 ? -13.052 -21.364 -20.801 1.00 62.35  ? 486 LEU   A CD2 1 
ATOM   728  N N   . CYS   A 1 114 ? -16.846 -18.369 -23.055 1.00 62.06  ? 487 CYS   A N   1 
ATOM   729  C CA  . CYS   A 1 114 ? -17.560 -17.601 -24.065 1.00 58.01  ? 487 CYS   A CA  1 
ATOM   730  C C   . CYS   A 1 114 ? -18.631 -16.731 -23.423 1.00 58.76  ? 487 CYS   A C   1 
ATOM   731  O O   . CYS   A 1 114 ? -18.909 -16.838 -22.228 1.00 58.30  ? 487 CYS   A O   1 
ATOM   732  C CB  . CYS   A 1 114 ? -18.162 -18.477 -25.158 1.00 60.09  ? 487 CYS   A CB  1 
ATOM   733  S SG  . CYS   A 1 114 ? -19.222 -19.811 -24.545 1.00 59.52  ? 487 CYS   A SG  1 
ATOM   734  N N   . GLU   A 1 115 ? -19.176 -15.832 -24.246 1.00 51.96  ? 488 GLU   A N   1 
ATOM   735  C CA  . GLU   A 1 115 ? -20.259 -14.952 -23.856 1.00 55.56  ? 488 GLU   A CA  1 
ATOM   736  C C   . GLU   A 1 115 ? -21.183 -14.834 -25.062 1.00 59.97  ? 488 GLU   A C   1 
ATOM   737  O O   . GLU   A 1 115 ? -20.752 -14.373 -26.114 1.00 62.27  ? 488 GLU   A O   1 
ATOM   738  C CB  . GLU   A 1 115 ? -19.728 -13.602 -23.373 1.00 57.93  ? 488 GLU   A CB  1 
ATOM   739  C CG  . GLU   A 1 115 ? -20.835 -12.681 -22.858 1.00 65.20  ? 488 GLU   A CG  1 
ATOM   740  C CD  . GLU   A 1 115 ? -20.419 -11.463 -22.044 1.00 66.70  ? 488 GLU   A CD  1 
ATOM   741  O OE1 . GLU   A 1 115 ? -19.231 -11.091 -22.087 1.00 73.26  ? 488 GLU   A OE1 1 
ATOM   742  O OE2 . GLU   A 1 115 ? -21.285 -10.892 -21.337 1.00 70.23  ? 488 GLU   A OE2 1 
ATOM   743  N N   . ILE   A 1 116 ? -22.432 -15.300 -24.923 1.00 57.37  ? 489 ILE   A N   1 
ATOM   744  C CA  . ILE   A 1 116 ? -23.371 -15.245 -26.032 1.00 53.68  ? 489 ILE   A CA  1 
ATOM   745  C C   . ILE   A 1 116 ? -24.394 -14.154 -25.751 1.00 50.36  ? 489 ILE   A C   1 
ATOM   746  O O   . ILE   A 1 116 ? -24.842 -13.989 -24.623 1.00 53.20  ? 489 ILE   A O   1 
ATOM   747  C CB  . ILE   A 1 116 ? -24.026 -16.605 -26.313 1.00 55.63  ? 489 ILE   A CB  1 
ATOM   748  C CG1 . ILE   A 1 116 ? -22.983 -17.699 -26.508 1.00 58.67  ? 489 ILE   A CG1 1 
ATOM   749  C CG2 . ILE   A 1 116 ? -24.964 -16.512 -27.521 1.00 58.70  ? 489 ILE   A CG2 1 
ATOM   750  C CD1 . ILE   A 1 116 ? -22.421 -18.261 -25.219 1.00 63.32  ? 489 ILE   A CD1 1 
ATOM   751  N N   . ASN   A 1 117 ? -24.706 -13.386 -26.797 1.00 53.08  ? 490 ASN   A N   1 
ATOM   752  C CA  . ASN   A 1 117 ? -25.696 -12.328 -26.732 1.00 59.17  ? 490 ASN   A CA  1 
ATOM   753  C C   . ASN   A 1 117 ? -27.054 -12.947 -27.066 1.00 60.91  ? 490 ASN   A C   1 
ATOM   754  O O   . ASN   A 1 117 ? -27.134 -13.825 -27.918 1.00 63.00  ? 490 ASN   A O   1 
ATOM   755  C CB  . ASN   A 1 117 ? -25.307 -11.180 -27.659 1.00 60.88  ? 490 ASN   A CB  1 
ATOM   756  C CG  . ASN   A 1 117 ? -25.367 -9.842  -26.960 1.00 66.43  ? 490 ASN   A CG  1 
ATOM   757  O OD1 . ASN   A 1 117 ? -26.456 -9.317  -26.691 1.00 60.69  ? 490 ASN   A OD1 1 
ATOM   758  N ND2 . ASN   A 1 117 ? -24.206 -9.287  -26.636 1.00 67.01  ? 490 ASN   A ND2 1 
ATOM   759  N N   . ILE   A 1 118 ? -28.105 -12.541 -26.348 1.00 63.93  ? 491 ILE   A N   1 
ATOM   760  C CA  . ILE   A 1 118 ? -29.470 -12.873 -26.734 1.00 79.28  ? 491 ILE   A CA  1 
ATOM   761  C C   . ILE   A 1 118 ? -29.972 -11.764 -27.661 1.00 95.19  ? 491 ILE   A C   1 
ATOM   762  O O   . ILE   A 1 118 ? -30.287 -10.656 -27.214 1.00 90.51  ? 491 ILE   A O   1 
ATOM   763  C CB  . ILE   A 1 118 ? -30.369 -13.104 -25.500 1.00 76.93  ? 491 ILE   A CB  1 
ATOM   764  C CG1 . ILE   A 1 118 ? -30.178 -14.519 -24.946 1.00 81.48  ? 491 ILE   A CG1 1 
ATOM   765  C CG2 . ILE   A 1 118 ? -31.847 -12.831 -25.777 1.00 76.62  ? 491 ILE   A CG2 1 
ATOM   766  C CD1 . ILE   A 1 118 ? -28.864 -14.736 -24.217 1.00 81.58  ? 491 ILE   A CD1 1 
ATOM   767  N N   . ASN   A 1 119 ? -29.992 -12.082 -28.966 1.00 103.16 ? 492 ASN   A N   1 
ATOM   768  C CA  . ASN   A 1 119 ? -30.451 -11.168 -30.001 1.00 110.40 ? 492 ASN   A CA  1 
ATOM   769  C C   . ASN   A 1 119 ? -31.960 -10.978 -29.843 1.00 111.06 ? 492 ASN   A C   1 
ATOM   770  O O   . ASN   A 1 119 ? -32.747 -11.627 -30.532 1.00 119.91 ? 492 ASN   A O   1 
ATOM   771  C CB  . ASN   A 1 119 ? -30.048 -11.660 -31.390 1.00 101.43 ? 492 ASN   A CB  1 
ATOM   772  N N   . ASP   A 1 120 ? -32.343 -10.091 -28.912 1.00 97.97  ? 493 ASP   A N   1 
ATOM   773  C CA  . ASP   A 1 120 ? -33.734 -9.909  -28.533 1.00 87.50  ? 493 ASP   A CA  1 
ATOM   774  C C   . ASP   A 1 120 ? -33.891 -8.614  -27.743 1.00 84.55  ? 493 ASP   A C   1 
ATOM   775  O O   . ASP   A 1 120 ? -32.924 -7.880  -27.527 1.00 81.48  ? 493 ASP   A O   1 
ATOM   776  C CB  . ASP   A 1 120 ? -34.264 -11.100 -27.742 1.00 92.72  ? 493 ASP   A CB  1 
ATOM   777  C CG  . ASP   A 1 120 ? -35.276 -11.992 -28.454 1.00 92.07  ? 493 ASP   A CG  1 
ATOM   778  O OD1 . ASP   A 1 120 ? -36.229 -11.441 -29.043 1.00 97.34  ? 493 ASP   A OD1 1 
ATOM   779  O OD2 . ASP   A 1 120 ? -35.132 -13.230 -28.376 1.00 80.34  ? 493 ASP   A OD2 1 
ATOM   780  N N   . ASN   A 1 121 ? -35.132 -8.385  -27.295 1.00 77.28  ? 494 ASN   A N   1 
ATOM   781  C CA  . ASN   A 1 121 ? -35.534 -7.190  -26.572 1.00 79.94  ? 494 ASN   A CA  1 
ATOM   782  C C   . ASN   A 1 121 ? -35.680 -7.487  -25.071 1.00 78.49  ? 494 ASN   A C   1 
ATOM   783  O O   . ASN   A 1 121 ? -36.282 -6.703  -24.331 1.00 68.15  ? 494 ASN   A O   1 
ATOM   784  C CB  . ASN   A 1 121 ? -36.792 -6.606  -27.218 1.00 84.95  ? 494 ASN   A CB  1 
ATOM   785  C CG  . ASN   A 1 121 ? -37.741 -7.643  -27.791 1.00 87.35  ? 494 ASN   A CG  1 
ATOM   786  O OD1 . ASN   A 1 121 ? -37.449 -8.846  -27.826 1.00 80.55  ? 494 ASN   A OD1 1 
ATOM   787  N ND2 . ASN   A 1 121 ? -38.890 -7.194  -28.273 1.00 91.44  ? 494 ASN   A ND2 1 
ATOM   788  N N   . MET   A 1 122 ? -35.076 -8.593  -24.611 1.00 68.38  ? 495 MET   A N   1 
ATOM   789  C CA  . MET   A 1 122 ? -35.352 -9.167  -23.301 1.00 59.66  ? 495 MET   A CA  1 
ATOM   790  C C   . MET   A 1 122 ? -34.057 -9.268  -22.506 1.00 48.02  ? 495 MET   A C   1 
ATOM   791  O O   . MET   A 1 122 ? -33.462 -10.332 -22.445 1.00 49.95  ? 495 MET   A O   1 
ATOM   792  C CB  . MET   A 1 122 ? -35.841 -10.612 -23.449 1.00 59.43  ? 495 MET   A CB  1 
ATOM   793  C CG  . MET   A 1 122 ? -36.994 -10.818 -24.400 1.00 59.88  ? 495 MET   A CG  1 
ATOM   794  S SD  . MET   A 1 122 ? -38.563 -10.484 -23.594 1.00 57.80  ? 495 MET   A SD  1 
ATOM   795  C CE  . MET   A 1 122 ? -39.852 -10.967 -24.752 1.00 60.97  ? 495 MET   A CE  1 
ATOM   796  N N   . PRO   A 1 123 ? -33.524 -8.185  -21.924 1.00 45.79  ? 496 PRO   A N   1 
ATOM   797  C CA  . PRO   A 1 123 ? -32.183 -8.246  -21.332 1.00 50.12  ? 496 PRO   A CA  1 
ATOM   798  C C   . PRO   A 1 123 ? -31.955 -8.981  -20.000 1.00 49.73  ? 496 PRO   A C   1 
ATOM   799  O O   . PRO   A 1 123 ? -30.809 -9.276  -19.641 1.00 44.34  ? 496 PRO   A O   1 
ATOM   800  C CB  . PRO   A 1 123 ? -31.894 -6.735  -21.198 1.00 45.22  ? 496 PRO   A CB  1 
ATOM   801  C CG  . PRO   A 1 123 ? -33.231 -6.124  -20.872 1.00 46.38  ? 496 PRO   A CG  1 
ATOM   802  C CD  . PRO   A 1 123 ? -34.161 -6.863  -21.816 1.00 50.34  ? 496 PRO   A CD  1 
ATOM   803  N N   . ARG   A 1 124 ? -33.021 -9.212  -19.225 1.00 45.93  ? 497 ARG   A N   1 
ATOM   804  C CA  . ARG   A 1 124 ? -32.860 -9.739  -17.874 1.00 43.69  ? 497 ARG   A CA  1 
ATOM   805  C C   . ARG   A 1 124 ? -32.869 -11.270 -17.901 1.00 39.18  ? 497 ARG   A C   1 
ATOM   806  O O   . ARG   A 1 124 ? -33.912 -11.892 -18.079 1.00 38.70  ? 497 ARG   A O   1 
ATOM   807  C CB  . ARG   A 1 124 ? -33.940 -9.154  -16.965 1.00 43.90  ? 497 ARG   A CB  1 
ATOM   808  C CG  . ARG   A 1 124 ? -33.813 -7.645  -16.832 1.00 44.60  ? 497 ARG   A CG  1 
ATOM   809  C CD  . ARG   A 1 124 ? -34.726 -7.073  -15.754 1.00 43.10  ? 497 ARG   A CD  1 
ATOM   810  N NE  . ARG   A 1 124 ? -36.117 -7.485  -15.970 1.00 43.63  ? 497 ARG   A NE  1 
ATOM   811  C CZ  . ARG   A 1 124 ? -36.964 -7.953  -15.057 1.00 45.09  ? 497 ARG   A CZ  1 
ATOM   812  N NH1 . ARG   A 1 124 ? -36.621 -8.015  -13.783 1.00 42.98  ? 497 ARG   A NH1 1 
ATOM   813  N NH2 . ARG   A 1 124 ? -38.168 -8.350  -15.431 1.00 45.88  ? 497 ARG   A NH2 1 
ATOM   814  N N   . ILE   A 1 125 ? -31.690 -11.873 -17.730 1.00 34.09  ? 498 ILE   A N   1 
ATOM   815  C CA  . ILE   A 1 125 ? -31.584 -13.323 -17.709 1.00 38.26  ? 498 ILE   A CA  1 
ATOM   816  C C   . ILE   A 1 125 ? -31.885 -13.790 -16.281 1.00 34.41  ? 498 ILE   A C   1 
ATOM   817  O O   . ILE   A 1 125 ? -30.994 -13.851 -15.452 1.00 34.33  ? 498 ILE   A O   1 
ATOM   818  C CB  . ILE   A 1 125 ? -30.209 -13.775 -18.231 1.00 38.03  ? 498 ILE   A CB  1 
ATOM   819  C CG1 . ILE   A 1 125 ? -29.929 -13.198 -19.622 1.00 42.71  ? 498 ILE   A CG1 1 
ATOM   820  C CG2 . ILE   A 1 125 ? -30.082 -15.300 -18.244 1.00 39.99  ? 498 ILE   A CG2 1 
ATOM   821  C CD1 . ILE   A 1 125 ? -31.037 -13.457 -20.636 1.00 42.15  ? 498 ILE   A CD1 1 
ATOM   822  N N   . LEU   A 1 126 ? -33.159 -14.077 -15.996 1.00 31.62  ? 499 LEU   A N   1 
ATOM   823  C CA  . LEU   A 1 126 ? -33.614 -14.197 -14.615 1.00 35.54  ? 499 LEU   A CA  1 
ATOM   824  C C   . LEU   A 1 126 ? -33.268 -15.577 -14.044 1.00 34.30  ? 499 LEU   A C   1 
ATOM   825  O O   . LEU   A 1 126 ? -33.074 -15.703 -12.844 1.00 33.80  ? 499 LEU   A O   1 
ATOM   826  C CB  . LEU   A 1 126 ? -35.117 -13.916 -14.525 1.00 35.90  ? 499 LEU   A CB  1 
ATOM   827  C CG  . LEU   A 1 126 ? -35.573 -12.463 -14.740 1.00 38.22  ? 499 LEU   A CG  1 
ATOM   828  C CD1 . LEU   A 1 126 ? -37.077 -12.318 -14.618 1.00 37.99  ? 499 LEU   A CD1 1 
ATOM   829  C CD2 . LEU   A 1 126 ? -34.947 -11.484 -13.782 1.00 39.71  ? 499 LEU   A CD2 1 
ATOM   830  N N   . SER   A 1 127 ? -33.196 -16.609 -14.892 1.00 33.53  ? 500 SER   A N   1 
ATOM   831  C CA  . SER   A 1 127 ? -33.062 -17.981 -14.426 1.00 34.81  ? 500 SER   A CA  1 
ATOM   832  C C   . SER   A 1 127 ? -32.251 -18.802 -15.422 1.00 32.75  ? 500 SER   A C   1 
ATOM   833  O O   . SER   A 1 127 ? -32.350 -18.598 -16.621 1.00 33.03  ? 500 SER   A O   1 
ATOM   834  C CB  . SER   A 1 127 ? -34.430 -18.576 -14.212 1.00 34.08  ? 500 SER   A CB  1 
ATOM   835  O OG  . SER   A 1 127 ? -34.350 -19.808 -13.510 1.00 41.07  ? 500 SER   A OG  1 
ATOM   836  N N   . LEU   A 1 128 ? -31.439 -19.725 -14.910 1.00 35.15  ? 501 LEU   A N   1 
ATOM   837  C CA  . LEU   A 1 128 ? -30.649 -20.641 -15.724 1.00 32.54  ? 501 LEU   A CA  1 
ATOM   838  C C   . LEU   A 1 128 ? -30.832 -22.039 -15.149 1.00 30.82  ? 501 LEU   A C   1 
ATOM   839  O O   . LEU   A 1 128 ? -30.725 -22.206 -13.940 1.00 33.94  ? 501 LEU   A O   1 
ATOM   840  C CB  . LEU   A 1 128 ? -29.169 -20.258 -15.660 1.00 32.65  ? 501 LEU   A CB  1 
ATOM   841  C CG  . LEU   A 1 128 ? -28.690 -19.087 -16.520 1.00 33.72  ? 501 LEU   A CG  1 
ATOM   842  C CD1 . LEU   A 1 128 ? -27.340 -18.604 -16.058 1.00 34.43  ? 501 LEU   A CD1 1 
ATOM   843  C CD2 . LEU   A 1 128 ? -28.608 -19.495 -17.951 1.00 33.66  ? 501 LEU   A CD2 1 
ATOM   844  N N   . ALA   A 1 129 ? -31.022 -23.042 -16.007 1.00 30.07  ? 502 ALA   A N   1 
ATOM   845  C CA  . ALA   A 1 129 ? -31.024 -24.417 -15.547 1.00 29.12  ? 502 ALA   A CA  1 
ATOM   846  C C   . ALA   A 1 129 ? -30.244 -25.292 -16.521 1.00 32.03  ? 502 ALA   A C   1 
ATOM   847  O O   . ALA   A 1 129 ? -30.574 -25.367 -17.703 1.00 32.21  ? 502 ALA   A O   1 
ATOM   848  C CB  . ALA   A 1 129 ? -32.432 -24.909 -15.381 1.00 26.23  ? 502 ALA   A CB  1 
ATOM   849  N N   . CYS   A 1 130 ? -29.255 -26.013 -15.988 1.00 33.14  ? 503 CYS   A N   1 
ATOM   850  C CA  . CYS   A 1 130 ? -28.488 -26.946 -16.791 1.00 33.01  ? 503 CYS   A CA  1 
ATOM   851  C C   . CYS   A 1 130 ? -29.136 -28.324 -16.705 1.00 33.83  ? 503 CYS   A C   1 
ATOM   852  O O   . CYS   A 1 130 ? -29.546 -28.766 -15.636 1.00 37.32  ? 503 CYS   A O   1 
ATOM   853  C CB  . CYS   A 1 130 ? -27.033 -26.901 -16.361 1.00 37.46  ? 503 CYS   A CB  1 
ATOM   854  S SG  . CYS   A 1 130 ? -25.973 -27.944 -17.384 1.00 40.80  ? 503 CYS   A SG  1 
ATOM   855  N N   . SER   A 1 131 ? -29.284 -28.997 -17.844 1.00 34.19  ? 504 SER   A N   1 
ATOM   856  C CA  . SER   A 1 131 ? -29.901 -30.313 -17.838 1.00 35.76  ? 504 SER   A CA  1 
ATOM   857  C C   . SER   A 1 131 ? -28.968 -31.288 -17.132 1.00 35.99  ? 504 SER   A C   1 
ATOM   858  O O   . SER   A 1 131 ? -27.753 -31.128 -17.193 1.00 36.33  ? 504 SER   A O   1 
ATOM   859  C CB  . SER   A 1 131 ? -30.250 -30.784 -19.221 1.00 39.07  ? 504 SER   A CB  1 
ATOM   860  O OG  . SER   A 1 131 ? -29.081 -31.038 -19.989 1.00 44.55  ? 504 SER   A OG  1 
ATOM   861  N N   . PRO   A 1 132 ? -29.507 -32.297 -16.410 1.00 36.58  ? 505 PRO   A N   1 
ATOM   862  C CA  . PRO   A 1 132 ? -28.680 -33.309 -15.750 1.00 40.49  ? 505 PRO   A CA  1 
ATOM   863  C C   . PRO   A 1 132 ? -27.655 -33.996 -16.650 1.00 41.21  ? 505 PRO   A C   1 
ATOM   864  O O   . PRO   A 1 132 ? -26.569 -34.324 -16.184 1.00 41.96  ? 505 PRO   A O   1 
ATOM   865  C CB  . PRO   A 1 132 ? -29.706 -34.329 -15.197 1.00 39.70  ? 505 PRO   A CB  1 
ATOM   866  C CG  . PRO   A 1 132 ? -30.965 -33.524 -15.053 1.00 41.97  ? 505 PRO   A CG  1 
ATOM   867  C CD  . PRO   A 1 132 ? -30.944 -32.511 -16.193 1.00 37.64  ? 505 PRO   A CD  1 
ATOM   868  N N   . ASN   A 1 133 ? -28.000 -34.212 -17.929 1.00 43.75  ? 506 ASN   A N   1 
ATOM   869  C CA  . ASN   A 1 133 ? -27.130 -34.954 -18.834 1.00 45.24  ? 506 ASN   A CA  1 
ATOM   870  C C   . ASN   A 1 133 ? -26.080 -34.032 -19.443 1.00 46.60  ? 506 ASN   A C   1 
ATOM   871  O O   . ASN   A 1 133 ? -25.193 -34.508 -20.153 1.00 48.64  ? 506 ASN   A O   1 
ATOM   872  C CB  . ASN   A 1 133 ? -27.895 -35.672 -19.940 1.00 48.92  ? 506 ASN   A CB  1 
ATOM   873  C CG  . ASN   A 1 133 ? -28.476 -34.730 -20.969 1.00 50.48  ? 506 ASN   A CG  1 
ATOM   874  O OD1 . ASN   A 1 133 ? -28.364 -33.504 -20.846 1.00 49.61  ? 506 ASN   A OD1 1 
ATOM   875  N ND2 . ASN   A 1 133 ? -29.106 -35.287 -21.988 1.00 54.10  ? 506 ASN   A ND2 1 
ATOM   876  N N   . GLY   A 1 134 ? -26.198 -32.720 -19.192 1.00 39.06  ? 507 GLY   A N   1 
ATOM   877  C CA  . GLY   A 1 134 ? -25.141 -31.791 -19.562 1.00 37.19  ? 507 GLY   A CA  1 
ATOM   878  C C   . GLY   A 1 134 ? -25.264 -31.267 -20.996 1.00 37.83  ? 507 GLY   A C   1 
ATOM   879  O O   . GLY   A 1 134 ? -24.580 -30.313 -21.352 1.00 39.69  ? 507 GLY   A O   1 
ATOM   880  N N   . ALA   A 1 135 ? -26.180 -31.829 -21.792 1.00 35.84  ? 508 ALA   A N   1 
ATOM   881  C CA  . ALA   A 1 135 ? -26.257 -31.522 -23.214 1.00 42.02  ? 508 ALA   A CA  1 
ATOM   882  C C   . ALA   A 1 135 ? -27.034 -30.227 -23.511 1.00 45.07  ? 508 ALA   A C   1 
ATOM   883  O O   . ALA   A 1 135 ? -26.860 -29.636 -24.582 1.00 45.03  ? 508 ALA   A O   1 
ATOM   884  C CB  . ALA   A 1 135 ? -26.861 -32.716 -23.933 1.00 40.86  ? 508 ALA   A CB  1 
ATOM   885  N N   . SER   A 1 136 ? -27.887 -29.757 -22.589 1.00 42.13  ? 509 SER   A N   1 
ATOM   886  C CA  . SER   A 1 136 ? -28.640 -28.530 -22.836 1.00 40.35  ? 509 SER   A CA  1 
ATOM   887  C C   . SER   A 1 136 ? -28.742 -27.679 -21.581 1.00 37.59  ? 509 SER   A C   1 
ATOM   888  O O   . SER   A 1 136 ? -28.526 -28.154 -20.477 1.00 38.41  ? 509 SER   A O   1 
ATOM   889  C CB  . SER   A 1 136 ? -30.022 -28.818 -23.371 1.00 40.13  ? 509 SER   A CB  1 
ATOM   890  O OG  . SER   A 1 136 ? -30.667 -29.812 -22.593 1.00 41.31  ? 509 SER   A OG  1 
ATOM   891  N N   . PHE   A 1 137 ? -29.073 -26.403 -21.772 1.00 38.18  ? 510 PHE   A N   1 
ATOM   892  C CA  . PHE   A 1 137 ? -29.521 -25.585 -20.664 1.00 36.09  ? 510 PHE   A CA  1 
ATOM   893  C C   . PHE   A 1 137 ? -30.658 -24.698 -21.137 1.00 36.71  ? 510 PHE   A C   1 
ATOM   894  O O   . PHE   A 1 137 ? -30.843 -24.521 -22.332 1.00 35.82  ? 510 PHE   A O   1 
ATOM   895  C CB  . PHE   A 1 137 ? -28.369 -24.788 -20.059 1.00 37.78  ? 510 PHE   A CB  1 
ATOM   896  C CG  . PHE   A 1 137 ? -27.849 -23.608 -20.862 1.00 35.47  ? 510 PHE   A CG  1 
ATOM   897  C CD1 . PHE   A 1 137 ? -26.845 -23.781 -21.807 1.00 37.66  ? 510 PHE   A CD1 1 
ATOM   898  C CD2 . PHE   A 1 137 ? -28.311 -22.328 -20.608 1.00 33.44  ? 510 PHE   A CD2 1 
ATOM   899  C CE1 . PHE   A 1 137 ? -26.336 -22.698 -22.491 1.00 38.57  ? 510 PHE   A CE1 1 
ATOM   900  C CE2 . PHE   A 1 137 ? -27.813 -21.245 -21.318 1.00 36.49  ? 510 PHE   A CE2 1 
ATOM   901  C CZ  . PHE   A 1 137 ? -26.827 -21.431 -22.256 1.00 36.38  ? 510 PHE   A CZ  1 
ATOM   902  N N   . VAL   A 1 138 ? -31.427 -24.181 -20.173 1.00 35.93  ? 511 VAL   A N   1 
ATOM   903  C CA  . VAL   A 1 138 ? -32.501 -23.257 -20.470 1.00 30.48  ? 511 VAL   A CA  1 
ATOM   904  C C   . VAL   A 1 138 ? -32.173 -21.963 -19.750 1.00 31.22  ? 511 VAL   A C   1 
ATOM   905  O O   . VAL   A 1 138 ? -31.474 -21.980 -18.744 1.00 29.73  ? 511 VAL   A O   1 
ATOM   906  C CB  . VAL   A 1 138 ? -33.902 -23.758 -20.089 1.00 33.64  ? 511 VAL   A CB  1 
ATOM   907  C CG1 . VAL   A 1 138 ? -34.243 -25.081 -20.760 1.00 36.21  ? 511 VAL   A CG1 1 
ATOM   908  C CG2 . VAL   A 1 138 ? -34.065 -23.868 -18.586 1.00 38.98  ? 511 VAL   A CG2 1 
ATOM   909  N N   . CYS   A 1 139 ? -32.618 -20.835 -20.305 1.00 30.30  ? 512 CYS   A N   1 
ATOM   910  C CA  . CYS   A 1 139 ? -32.615 -19.611 -19.534 1.00 30.31  ? 512 CYS   A CA  1 
ATOM   911  C C   . CYS   A 1 139 ? -33.929 -18.903 -19.775 1.00 31.96  ? 512 CYS   A C   1 
ATOM   912  O O   . CYS   A 1 139 ? -34.593 -19.141 -20.783 1.00 34.14  ? 512 CYS   A O   1 
ATOM   913  C CB  . CYS   A 1 139 ? -31.418 -18.727 -19.860 1.00 35.19  ? 512 CYS   A CB  1 
ATOM   914  S SG  . CYS   A 1 139 ? -31.560 -17.856 -21.439 1.00 39.64  ? 512 CYS   A SG  1 
ATOM   915  N N   . SER   A 1 140 ? -34.313 -18.076 -18.805 1.00 33.60  ? 513 SER   A N   1 
ATOM   916  C CA  . SER   A 1 140 ? -35.411 -17.165 -19.009 1.00 35.88  ? 513 SER   A CA  1 
ATOM   917  C C   . SER   A 1 140 ? -34.796 -15.812 -19.320 1.00 35.89  ? 513 SER   A C   1 
ATOM   918  O O   . SER   A 1 140 ? -33.721 -15.501 -18.814 1.00 34.08  ? 513 SER   A O   1 
ATOM   919  C CB  . SER   A 1 140 ? -36.352 -17.110 -17.823 1.00 37.39  ? 513 SER   A CB  1 
ATOM   920  O OG  . SER   A 1 140 ? -35.717 -16.513 -16.711 1.00 38.83  ? 513 SER   A OG  1 
ATOM   921  N N   . ALA   A 1 141 ? -35.472 -15.057 -20.188 1.00 35.29  ? 514 ALA   A N   1 
ATOM   922  C CA  . ALA   A 1 141 ? -35.024 -13.726 -20.569 1.00 37.51  ? 514 ALA   A CA  1 
ATOM   923  C C   . ALA   A 1 141 ? -36.243 -12.814 -20.590 1.00 33.11  ? 514 ALA   A C   1 
ATOM   924  O O   . ALA   A 1 141 ? -37.192 -13.083 -21.316 1.00 36.78  ? 514 ALA   A O   1 
ATOM   925  C CB  . ALA   A 1 141 ? -34.331 -13.798 -21.917 1.00 36.18  ? 514 ALA   A CB  1 
ATOM   926  N N   . ALA   A 1 142 ? -36.230 -11.777 -19.762 1.00 35.71  ? 515 ALA   A N   1 
ATOM   927  C CA  . ALA   A 1 142 ? -37.405 -10.952 -19.550 1.00 39.54  ? 515 ALA   A CA  1 
ATOM   928  C C   . ALA   A 1 142 ? -37.106 -9.506  -19.931 1.00 43.48  ? 515 ALA   A C   1 
ATOM   929  O O   . ALA   A 1 142 ? -35.974 -9.046  -19.837 1.00 42.36  ? 515 ALA   A O   1 
ATOM   930  C CB  . ALA   A 1 142 ? -37.843 -11.031 -18.099 1.00 36.78  ? 515 ALA   A CB  1 
ATOM   931  N N   . ALA   A 1 143 ? -38.166 -8.798  -20.316 1.00 49.72  ? 516 ALA   A N   1 
ATOM   932  C CA  . ALA   A 1 143 ? -38.116 -7.369  -20.566 1.00 50.52  ? 516 ALA   A CA  1 
ATOM   933  C C   . ALA   A 1 143 ? -37.806 -6.624  -19.272 1.00 51.47  ? 516 ALA   A C   1 
ATOM   934  O O   . ALA   A 1 143 ? -37.914 -7.191  -18.182 1.00 45.40  ? 516 ALA   A O   1 
ATOM   935  C CB  . ALA   A 1 143 ? -39.446 -6.927  -21.141 1.00 48.86  ? 516 ALA   A CB  1 
ATOM   936  N N   . PRO   A 1 144 ? -37.455 -5.318  -19.341 1.00 51.22  ? 517 PRO   A N   1 
ATOM   937  C CA  . PRO   A 1 144 ? -37.174 -4.545  -18.134 1.00 50.42  ? 517 PRO   A CA  1 
ATOM   938  C C   . PRO   A 1 144 ? -38.392 -4.508  -17.220 1.00 50.93  ? 517 PRO   A C   1 
ATOM   939  O O   . PRO   A 1 144 ? -39.523 -4.538  -17.694 1.00 50.52  ? 517 PRO   A O   1 
ATOM   940  C CB  . PRO   A 1 144 ? -36.806 -3.148  -18.683 1.00 52.32  ? 517 PRO   A CB  1 
ATOM   941  C CG  . PRO   A 1 144 ? -36.366 -3.409  -20.115 1.00 49.12  ? 517 PRO   A CG  1 
ATOM   942  C CD  . PRO   A 1 144 ? -37.290 -4.524  -20.573 1.00 51.84  ? 517 PRO   A CD  1 
ATOM   943  N N   . SER   A 1 145 ? -38.146 -4.444  -15.909 1.00 54.75  ? 518 SER   A N   1 
ATOM   944  C CA  . SER   A 1 145 ? -39.203 -4.177  -14.949 1.00 60.18  ? 518 SER   A CA  1 
ATOM   945  C C   . SER   A 1 145 ? -39.851 -2.831  -15.281 1.00 65.29  ? 518 SER   A C   1 
ATOM   946  O O   . SER   A 1 145 ? -39.205 -1.956  -15.853 1.00 66.59  ? 518 SER   A O   1 
ATOM   947  C CB  . SER   A 1 145 ? -38.671 -4.207  -13.531 1.00 59.89  ? 518 SER   A CB  1 
ATOM   948  N N   . LEU   A 1 146 ? -41.135 -2.686  -14.936 1.00 68.83  ? 519 LEU   A N   1 
ATOM   949  C CA  . LEU   A 1 146 ? -41.859 -1.436  -15.113 1.00 74.45  ? 519 LEU   A CA  1 
ATOM   950  C C   . LEU   A 1 146 ? -41.417 -0.438  -14.042 1.00 81.96  ? 519 LEU   A C   1 
ATOM   951  O O   . LEU   A 1 146 ? -41.094 -0.830  -12.919 1.00 73.95  ? 519 LEU   A O   1 
ATOM   952  C CB  . LEU   A 1 146 ? -43.369 -1.679  -15.031 1.00 73.25  ? 519 LEU   A CB  1 
ATOM   953  C CG  . LEU   A 1 146 ? -43.970 -2.662  -16.044 1.00 78.05  ? 519 LEU   A CG  1 
ATOM   954  C CD1 . LEU   A 1 146 ? -45.413 -2.994  -15.670 1.00 78.42  ? 519 LEU   A CD1 1 
ATOM   955  C CD2 . LEU   A 1 146 ? -43.885 -2.145  -17.478 1.00 73.53  ? 519 LEU   A CD2 1 
ATOM   956  N N   . THR   A 1 147 ? -41.424 0.855   -14.407 1.00 97.73  ? 520 THR   A N   1 
ATOM   957  C CA  . THR   A 1 147 ? -41.245 1.944   -13.458 1.00 100.50 ? 520 THR   A CA  1 
ATOM   958  C C   . THR   A 1 147 ? -42.460 2.000   -12.550 1.00 100.75 ? 520 THR   A C   1 
ATOM   959  O O   . THR   A 1 147 ? -42.677 3.073   -11.949 1.00 108.33 ? 520 THR   A O   1 
ATOM   960  C CB  . THR   A 1 147 ? -41.036 3.259   -14.211 1.00 93.66  ? 520 THR   A CB  1 
ATOM   961  N N   . MET   A 1 162 ? -43.351 -3.075  -11.630 1.00 98.97  ? 535 MET   A N   1 
ATOM   962  C CA  . MET   A 1 162 ? -43.842 -4.471  -11.466 1.00 95.82  ? 535 MET   A CA  1 
ATOM   963  C C   . MET   A 1 162 ? -43.111 -5.391  -12.446 1.00 89.08  ? 535 MET   A C   1 
ATOM   964  O O   . MET   A 1 162 ? -42.525 -4.920  -13.426 1.00 69.72  ? 535 MET   A O   1 
ATOM   965  C CB  . MET   A 1 162 ? -45.357 -4.553  -11.697 1.00 98.65  ? 535 MET   A CB  1 
ATOM   966  C CG  . MET   A 1 162 ? -46.033 -5.690  -10.955 1.00 106.71 ? 535 MET   A CG  1 
ATOM   967  S SD  . MET   A 1 162 ? -47.830 -5.545  -10.998 1.00 120.79 ? 535 MET   A SD  1 
ATOM   968  C CE  . MET   A 1 162 ? -48.348 -6.865  -9.891  1.00 119.57 ? 535 MET   A CE  1 
ATOM   969  N N   . ASN   A 1 163 ? -43.162 -6.704  -12.158 1.00 77.11  ? 536 ASN   A N   1 
ATOM   970  C CA  . ASN   A 1 163 ? -42.496 -7.718  -12.962 1.00 71.58  ? 536 ASN   A CA  1 
ATOM   971  C C   . ASN   A 1 163 ? -43.499 -8.367  -13.920 1.00 62.95  ? 536 ASN   A C   1 
ATOM   972  O O   . ASN   A 1 163 ? -43.187 -9.388  -14.518 1.00 58.35  ? 536 ASN   A O   1 
ATOM   973  C CB  . ASN   A 1 163 ? -41.778 -8.742  -12.078 1.00 73.53  ? 536 ASN   A CB  1 
ATOM   974  C CG  . ASN   A 1 163 ? -40.710 -9.544  -12.801 1.00 69.86  ? 536 ASN   A CG  1 
ATOM   975  O OD1 . ASN   A 1 163 ? -40.137 -9.066  -13.790 1.00 62.73  ? 536 ASN   A OD1 1 
ATOM   976  N ND2 . ASN   A 1 163 ? -40.400 -10.746 -12.309 1.00 55.84  ? 536 ASN   A ND2 1 
ATOM   977  N N   . GLN   A 1 164 ? -44.683 -7.759  -14.099 1.00 60.47  ? 537 GLN   A N   1 
ATOM   978  C CA  . GLN   A 1 164 ? -45.684 -8.260  -15.030 1.00 61.49  ? 537 GLN   A CA  1 
ATOM   979  C C   . GLN   A 1 164 ? -45.311 -7.865  -16.456 1.00 57.91  ? 537 GLN   A C   1 
ATOM   980  O O   . GLN   A 1 164 ? -46.052 -7.164  -17.138 1.00 56.75  ? 537 GLN   A O   1 
ATOM   981  C CB  . GLN   A 1 164 ? -47.068 -7.679  -14.734 1.00 73.19  ? 537 GLN   A CB  1 
ATOM   982  C CG  . GLN   A 1 164 ? -47.649 -8.129  -13.402 1.00 82.33  ? 537 GLN   A CG  1 
ATOM   983  C CD  . GLN   A 1 164 ? -47.607 -9.630  -13.248 1.00 81.24  ? 537 GLN   A CD  1 
ATOM   984  O OE1 . GLN   A 1 164 ? -48.147 -10.380 -14.074 1.00 71.69  ? 537 GLN   A OE1 1 
ATOM   985  N NE2 . GLN   A 1 164 ? -46.916 -10.066 -12.203 1.00 78.16  ? 537 GLN   A NE2 1 
ATOM   986  N N   . VAL   A 1 165 ? -44.153 -8.327  -16.913 1.00 51.58  ? 538 VAL   A N   1 
ATOM   987  C CA  . VAL   A 1 165 ? -43.637 -7.876  -18.186 1.00 47.73  ? 538 VAL   A CA  1 
ATOM   988  C C   . VAL   A 1 165 ? -43.398 -9.109  -19.043 1.00 46.33  ? 538 VAL   A C   1 
ATOM   989  O O   . VAL   A 1 165 ? -43.377 -10.225 -18.527 1.00 44.03  ? 538 VAL   A O   1 
ATOM   990  C CB  . VAL   A 1 165 ? -42.357 -7.048  -17.984 1.00 49.46  ? 538 VAL   A CB  1 
ATOM   991  C CG1 . VAL   A 1 165 ? -42.659 -5.728  -17.290 1.00 48.66  ? 538 VAL   A CG1 1 
ATOM   992  C CG2 . VAL   A 1 165 ? -41.291 -7.831  -17.225 1.00 48.94  ? 538 VAL   A CG2 1 
ATOM   993  N N   . PRO   A 1 166 ? -43.250 -8.933  -20.372 1.00 38.54  ? 539 PRO   A N   1 
ATOM   994  C CA  . PRO   A 1 166 ? -42.989 -10.053 -21.261 1.00 39.93  ? 539 PRO   A CA  1 
ATOM   995  C C   . PRO   A 1 166 ? -41.692 -10.763 -20.895 1.00 36.19  ? 539 PRO   A C   1 
ATOM   996  O O   . PRO   A 1 166 ? -40.787 -10.167 -20.339 1.00 34.54  ? 539 PRO   A O   1 
ATOM   997  C CB  . PRO   A 1 166 ? -42.919 -9.365  -22.649 1.00 40.04  ? 539 PRO   A CB  1 
ATOM   998  C CG  . PRO   A 1 166 ? -43.773 -8.122  -22.480 1.00 39.37  ? 539 PRO   A CG  1 
ATOM   999  C CD  . PRO   A 1 166 ? -43.374 -7.655  -21.095 1.00 38.95  ? 539 PRO   A CD  1 
ATOM   1000 N N   . GLY   A 1 167 ? -41.613 -12.042 -21.249 1.00 34.03  ? 540 GLY   A N   1 
ATOM   1001 C CA  . GLY   A 1 167 ? -40.347 -12.731 -21.177 1.00 34.75  ? 540 GLY   A CA  1 
ATOM   1002 C C   . GLY   A 1 167 ? -40.381 -13.938 -22.085 1.00 33.28  ? 540 GLY   A C   1 
ATOM   1003 O O   . GLY   A 1 167 ? -41.444 -14.290 -22.594 1.00 33.30  ? 540 GLY   A O   1 
ATOM   1004 N N   . ARG   A 1 168 ? -39.209 -14.551 -22.256 1.00 33.15  ? 541 ARG   A N   1 
ATOM   1005 C CA  . ARG   A 1 168 ? -39.090 -15.742 -23.071 1.00 37.57  ? 541 ARG   A CA  1 
ATOM   1006 C C   . ARG   A 1 168 ? -38.369 -16.808 -22.266 1.00 33.36  ? 541 ARG   A C   1 
ATOM   1007 O O   . ARG   A 1 168 ? -37.733 -16.515 -21.254 1.00 37.80  ? 541 ARG   A O   1 
ATOM   1008 C CB  . ARG   A 1 168 ? -38.282 -15.485 -24.350 1.00 43.20  ? 541 ARG   A CB  1 
ATOM   1009 C CG  . ARG   A 1 168 ? -38.705 -14.254 -25.141 1.00 52.79  ? 541 ARG   A CG  1 
ATOM   1010 C CD  . ARG   A 1 168 ? -38.034 -14.192 -26.521 1.00 59.80  ? 541 ARG   A CD  1 
ATOM   1011 N NE  . ARG   A 1 168 ? -38.330 -12.981 -27.302 1.00 65.02  ? 541 ARG   A NE  1 
ATOM   1012 C CZ  . ARG   A 1 168 ? -39.462 -12.709 -27.959 1.00 70.99  ? 541 ARG   A CZ  1 
ATOM   1013 N NH1 . ARG   A 1 168 ? -40.475 -13.564 -27.978 1.00 76.24  ? 541 ARG   A NH1 1 
ATOM   1014 N NH2 . ARG   A 1 168 ? -39.584 -11.567 -28.610 1.00 73.07  ? 541 ARG   A NH2 1 
ATOM   1015 N N   . LEU   A 1 169 ? -38.450 -18.030 -22.781 1.00 33.98  ? 542 LEU   A N   1 
ATOM   1016 C CA  . LEU   A 1 169 ? -37.772 -19.179 -22.225 1.00 35.44  ? 542 LEU   A CA  1 
ATOM   1017 C C   . LEU   A 1 169 ? -36.996 -19.865 -23.350 1.00 36.49  ? 542 LEU   A C   1 
ATOM   1018 O O   . LEU   A 1 169 ? -37.593 -20.344 -24.312 1.00 37.08  ? 542 LEU   A O   1 
ATOM   1019 C CB  . LEU   A 1 169 ? -38.850 -20.081 -21.629 1.00 33.72  ? 542 LEU   A CB  1 
ATOM   1020 C CG  . LEU   A 1 169 ? -38.342 -21.369 -20.976 1.00 34.54  ? 542 LEU   A CG  1 
ATOM   1021 C CD1 . LEU   A 1 169 ? -37.511 -21.052 -19.757 1.00 33.82  ? 542 LEU   A CD1 1 
ATOM   1022 C CD2 . LEU   A 1 169 ? -39.488 -22.287 -20.619 1.00 36.93  ? 542 LEU   A CD2 1 
ATOM   1023 N N   . LEU   A 1 170 ? -35.667 -19.913 -23.222 1.00 38.89  ? 543 LEU   A N   1 
ATOM   1024 C CA  . LEU   A 1 170 ? -34.803 -20.350 -24.310 1.00 38.59  ? 543 LEU   A CA  1 
ATOM   1025 C C   . LEU   A 1 170 ? -34.181 -21.700 -23.968 1.00 37.14  ? 543 LEU   A C   1 
ATOM   1026 O O   . LEU   A 1 170 ? -33.676 -21.860 -22.859 1.00 34.57  ? 543 LEU   A O   1 
ATOM   1027 C CB  . LEU   A 1 170 ? -33.696 -19.326 -24.566 1.00 39.26  ? 543 LEU   A CB  1 
ATOM   1028 C CG  . LEU   A 1 170 ? -34.102 -17.852 -24.635 1.00 45.16  ? 543 LEU   A CG  1 
ATOM   1029 C CD1 . LEU   A 1 170 ? -32.924 -17.031 -25.107 1.00 46.64  ? 543 LEU   A CD1 1 
ATOM   1030 C CD2 . LEU   A 1 170 ? -35.288 -17.606 -25.522 1.00 52.57  ? 543 LEU   A CD2 1 
ATOM   1031 N N   . LEU   A 1 171 ? -34.208 -22.634 -24.935 1.00 34.11  ? 544 LEU   A N   1 
ATOM   1032 C CA  . LEU   A 1 171 ? -33.446 -23.869 -24.881 1.00 36.49  ? 544 LEU   A CA  1 
ATOM   1033 C C   . LEU   A 1 171 ? -32.158 -23.695 -25.689 1.00 40.92  ? 544 LEU   A C   1 
ATOM   1034 O O   . LEU   A 1 171 ? -32.195 -23.201 -26.811 1.00 39.06  ? 544 LEU   A O   1 
ATOM   1035 C CB  . LEU   A 1 171 ? -34.273 -25.025 -25.432 1.00 36.49  ? 544 LEU   A CB  1 
ATOM   1036 C CG  . LEU   A 1 171 ? -33.572 -26.385 -25.512 1.00 38.74  ? 544 LEU   A CG  1 
ATOM   1037 C CD1 . LEU   A 1 171 ? -33.201 -26.868 -24.119 1.00 41.69  ? 544 LEU   A CD1 1 
ATOM   1038 C CD2 . LEU   A 1 171 ? -34.423 -27.429 -26.211 1.00 39.26  ? 544 LEU   A CD2 1 
ATOM   1039 N N   . TRP   A 1 172 ? -31.030 -24.111 -25.102 1.00 39.32  ? 545 TRP   A N   1 
ATOM   1040 C CA  . TRP   A 1 172 ? -29.717 -24.019 -25.724 1.00 40.86  ? 545 TRP   A CA  1 
ATOM   1041 C C   . TRP   A 1 172 ? -29.075 -25.391 -25.821 1.00 39.87  ? 545 TRP   A C   1 
ATOM   1042 O O   . TRP   A 1 172 ? -29.351 -26.274 -25.007 1.00 43.14  ? 545 TRP   A O   1 
ATOM   1043 C CB  . TRP   A 1 172 ? -28.764 -23.168 -24.888 1.00 38.43  ? 545 TRP   A CB  1 
ATOM   1044 C CG  . TRP   A 1 172 ? -29.166 -21.747 -24.674 1.00 38.44  ? 545 TRP   A CG  1 
ATOM   1045 C CD1 . TRP   A 1 172 ? -30.243 -21.281 -23.986 1.00 42.07  ? 545 TRP   A CD1 1 
ATOM   1046 C CD2 . TRP   A 1 172 ? -28.393 -20.600 -25.059 1.00 43.14  ? 545 TRP   A CD2 1 
ATOM   1047 N NE1 . TRP   A 1 172 ? -30.225 -19.914 -23.963 1.00 43.26  ? 545 TRP   A NE1 1 
ATOM   1048 C CE2 . TRP   A 1 172 ? -29.099 -19.467 -24.600 1.00 45.03  ? 545 TRP   A CE2 1 
ATOM   1049 C CE3 . TRP   A 1 172 ? -27.192 -20.422 -25.756 1.00 45.56  ? 545 TRP   A CE3 1 
ATOM   1050 C CZ2 . TRP   A 1 172 ? -28.636 -18.172 -24.811 1.00 46.62  ? 545 TRP   A CZ2 1 
ATOM   1051 C CZ3 . TRP   A 1 172 ? -26.738 -19.138 -25.964 1.00 48.95  ? 545 TRP   A CZ3 1 
ATOM   1052 C CH2 . TRP   A 1 172 ? -27.451 -18.029 -25.498 1.00 49.96  ? 545 TRP   A CH2 1 
ATOM   1053 N N   . ASP   A 1 173 ? -28.149 -25.510 -26.775 1.00 47.50  ? 546 ASP   A N   1 
ATOM   1054 C CA  . ASP   A 1 173 ? -27.289 -26.674 -26.919 1.00 45.77  ? 546 ASP   A CA  1 
ATOM   1055 C C   . ASP   A 1 173 ? -25.945 -26.353 -26.262 1.00 44.88  ? 546 ASP   A C   1 
ATOM   1056 O O   . ASP   A 1 173 ? -25.318 -25.364 -26.626 1.00 43.55  ? 546 ASP   A O   1 
ATOM   1057 C CB  . ASP   A 1 173 ? -27.149 -27.009 -28.393 1.00 50.15  ? 546 ASP   A CB  1 
ATOM   1058 C CG  . ASP   A 1 173 ? -26.172 -28.129 -28.704 1.00 48.32  ? 546 ASP   A CG  1 
ATOM   1059 O OD1 . ASP   A 1 173 ? -26.537 -29.296 -28.494 1.00 52.39  ? 546 ASP   A OD1 1 
ATOM   1060 O OD2 . ASP   A 1 173 ? -25.050 -27.812 -29.114 1.00 55.76  ? 546 ASP   A OD2 1 
ATOM   1061 N N   . THR   A 1 174 ? -25.505 -27.173 -25.294 1.00 42.91  ? 547 THR   A N   1 
ATOM   1062 C CA  . THR   A 1 174 ? -24.309 -26.862 -24.515 1.00 41.89  ? 547 THR   A CA  1 
ATOM   1063 C C   . THR   A 1 174 ? -23.032 -27.143 -25.306 1.00 39.78  ? 547 THR   A C   1 
ATOM   1064 O O   . THR   A 1 174 ? -22.033 -26.495 -25.058 1.00 47.48  ? 547 THR   A O   1 
ATOM   1065 C CB  . THR   A 1 174 ? -24.280 -27.629 -23.195 1.00 42.12  ? 547 THR   A CB  1 
ATOM   1066 O OG1 . THR   A 1 174 ? -24.217 -29.006 -23.569 1.00 42.93  ? 547 THR   A OG1 1 
ATOM   1067 C CG2 . THR   A 1 174 ? -25.468 -27.304 -22.300 1.00 43.36  ? 547 THR   A CG2 1 
ATOM   1068 N N   . LYS   A 1 175 ? -23.044 -28.107 -26.226 1.00 46.84  ? 548 LYS   A N   1 
ATOM   1069 C CA  . LYS   A 1 175 ? -21.861 -28.397 -27.027 1.00 51.97  ? 548 LYS   A CA  1 
ATOM   1070 C C   . LYS   A 1 175 ? -21.530 -27.211 -27.938 1.00 53.60  ? 548 LYS   A C   1 
ATOM   1071 O O   . LYS   A 1 175 ? -20.358 -26.870 -28.058 1.00 58.71  ? 548 LYS   A O   1 
ATOM   1072 C CB  . LYS   A 1 175 ? -21.965 -29.717 -27.806 1.00 53.40  ? 548 LYS   A CB  1 
ATOM   1073 N N   . THR   A 1 176 ? -22.539 -26.553 -28.542 1.00 51.94  ? 549 THR   A N   1 
ATOM   1074 C CA  . THR   A 1 176 ? -22.285 -25.418 -29.430 1.00 46.65  ? 549 THR   A CA  1 
ATOM   1075 C C   . THR   A 1 176 ? -22.433 -24.087 -28.699 1.00 46.52  ? 549 THR   A C   1 
ATOM   1076 O O   . THR   A 1 176 ? -22.017 -23.056 -29.218 1.00 49.30  ? 549 THR   A O   1 
ATOM   1077 C CB  . THR   A 1 176 ? -23.209 -25.450 -30.651 1.00 51.43  ? 549 THR   A CB  1 
ATOM   1078 O OG1 . THR   A 1 176 ? -24.562 -25.442 -30.195 1.00 45.72  ? 549 THR   A OG1 1 
ATOM   1079 C CG2 . THR   A 1 176 ? -22.958 -26.655 -31.544 1.00 50.74  ? 549 THR   A CG2 1 
ATOM   1080 N N   . MET   A 1 177 ? -23.062 -24.094 -27.518 1.00 45.45  ? 550 MET   A N   1 
ATOM   1081 C CA  . MET   A 1 177 ? -23.481 -22.871 -26.840 1.00 42.01  ? 550 MET   A CA  1 
ATOM   1082 C C   . MET   A 1 177 ? -24.270 -21.954 -27.778 1.00 40.00  ? 550 MET   A C   1 
ATOM   1083 O O   . MET   A 1 177 ? -24.143 -20.731 -27.714 1.00 41.54  ? 550 MET   A O   1 
ATOM   1084 C CB  . MET   A 1 177 ? -22.288 -22.136 -26.217 1.00 44.14  ? 550 MET   A CB  1 
ATOM   1085 C CG  . MET   A 1 177 ? -21.736 -22.814 -24.967 1.00 46.07  ? 550 MET   A CG  1 
ATOM   1086 S SD  . MET   A 1 177 ? -22.861 -22.831 -23.551 1.00 42.24  ? 550 MET   A SD  1 
ATOM   1087 C CE  . MET   A 1 177 ? -23.034 -21.083 -23.195 1.00 39.42  ? 550 MET   A CE  1 
ATOM   1088 N N   . LYS   A 1 178 ? -25.124 -22.560 -28.611 1.00 41.98  ? 551 LYS   A N   1 
ATOM   1089 C CA  . LYS   A 1 178 ? -26.055 -21.835 -29.465 1.00 47.01  ? 551 LYS   A CA  1 
ATOM   1090 C C   . LYS   A 1 178 ? -27.486 -22.069 -28.967 1.00 45.68  ? 551 LYS   A C   1 
ATOM   1091 O O   . LYS   A 1 178 ? -27.798 -23.126 -28.417 1.00 39.00  ? 551 LYS   A O   1 
ATOM   1092 C CB  . LYS   A 1 178 ? -25.934 -22.342 -30.911 1.00 50.77  ? 551 LYS   A CB  1 
ATOM   1093 C CG  . LYS   A 1 178 ? -24.849 -21.690 -31.789 1.00 52.58  ? 551 LYS   A CG  1 
ATOM   1094 N N   . GLN   A 1 179 ? -28.360 -21.079 -29.165 1.00 44.24  ? 552 GLN   A N   1 
ATOM   1095 C CA  . GLN   A 1 179 ? -29.778 -21.273 -28.936 1.00 43.35  ? 552 GLN   A CA  1 
ATOM   1096 C C   . GLN   A 1 179 ? -30.337 -22.263 -29.950 1.00 40.14  ? 552 GLN   A C   1 
ATOM   1097 O O   . GLN   A 1 179 ? -29.989 -22.187 -31.115 1.00 38.91  ? 552 GLN   A O   1 
ATOM   1098 C CB  . GLN   A 1 179 ? -30.599 -20.027 -29.204 1.00 42.30  ? 552 GLN   A CB  1 
ATOM   1099 C CG  . GLN   A 1 179 ? -30.483 -18.937 -28.157 1.00 47.16  ? 552 GLN   A CG  1 
ATOM   1100 C CD  . GLN   A 1 179 ? -31.601 -17.928 -28.319 1.00 50.55  ? 552 GLN   A CD  1 
ATOM   1101 O OE1 . GLN   A 1 179 ? -32.783 -18.276 -28.463 1.00 49.01  ? 552 GLN   A OE1 1 
ATOM   1102 N NE2 . GLN   A 1 179 ? -31.228 -16.661 -28.328 1.00 50.28  ? 552 GLN   A NE2 1 
ATOM   1103 N N   . GLN   A 1 180 ? -31.220 -23.161 -29.497 1.00 40.34  ? 553 GLN   A N   1 
ATOM   1104 C CA  . GLN   A 1 180 ? -31.904 -24.098 -30.364 1.00 40.34  ? 553 GLN   A CA  1 
ATOM   1105 C C   . GLN   A 1 180 ? -33.348 -23.673 -30.619 1.00 42.83  ? 553 GLN   A C   1 
ATOM   1106 O O   . GLN   A 1 180 ? -33.822 -23.773 -31.744 1.00 43.50  ? 553 GLN   A O   1 
ATOM   1107 C CB  . GLN   A 1 180 ? -31.921 -25.475 -29.721 1.00 41.45  ? 553 GLN   A CB  1 
ATOM   1108 C CG  . GLN   A 1 180 ? -32.712 -26.502 -30.525 1.00 41.09  ? 553 GLN   A CG  1 
ATOM   1109 C CD  . GLN   A 1 180 ? -32.791 -27.834 -29.819 1.00 44.45  ? 553 GLN   A CD  1 
ATOM   1110 O OE1 . GLN   A 1 180 ? -32.042 -28.089 -28.872 1.00 47.96  ? 553 GLN   A OE1 1 
ATOM   1111 N NE2 . GLN   A 1 180 ? -33.698 -28.694 -30.267 1.00 44.87  ? 553 GLN   A NE2 1 
ATOM   1112 N N   . LEU   A 1 181 ? -34.069 -23.267 -29.568 1.00 41.80  ? 554 LEU   A N   1 
ATOM   1113 C CA  . LEU   A 1 181 ? -35.463 -22.862 -29.715 1.00 42.97  ? 554 LEU   A CA  1 
ATOM   1114 C C   . LEU   A 1 181 ? -35.896 -22.042 -28.509 1.00 40.84  ? 554 LEU   A C   1 
ATOM   1115 O O   . LEU   A 1 181 ? -35.182 -21.982 -27.507 1.00 41.80  ? 554 LEU   A O   1 
ATOM   1116 C CB  . LEU   A 1 181 ? -36.380 -24.066 -29.919 1.00 41.23  ? 554 LEU   A CB  1 
ATOM   1117 C CG  . LEU   A 1 181 ? -36.373 -25.141 -28.828 1.00 41.47  ? 554 LEU   A CG  1 
ATOM   1118 C CD1 . LEU   A 1 181 ? -37.358 -24.799 -27.700 1.00 45.96  ? 554 LEU   A CD1 1 
ATOM   1119 C CD2 . LEU   A 1 181 ? -36.705 -26.511 -29.408 1.00 38.84  ? 554 LEU   A CD2 1 
ATOM   1120 N N   . GLN   A 1 182 ? -37.072 -21.419 -28.625 1.00 40.79  ? 555 GLN   A N   1 
ATOM   1121 C CA  . GLN   A 1 182 ? -37.728 -20.824 -27.467 1.00 48.16  ? 555 GLN   A CA  1 
ATOM   1122 C C   . GLN   A 1 182 ? -39.134 -21.409 -27.320 1.00 43.63  ? 555 GLN   A C   1 
ATOM   1123 O O   . GLN   A 1 182 ? -39.833 -21.599 -28.306 1.00 44.61  ? 555 GLN   A O   1 
ATOM   1124 C CB  . GLN   A 1 182 ? -37.780 -19.298 -27.528 1.00 47.21  ? 555 GLN   A CB  1 
ATOM   1125 C CG  . GLN   A 1 182 ? -39.076 -18.783 -28.135 1.00 59.73  ? 555 GLN   A CG  1 
ATOM   1126 C CD  . GLN   A 1 182 ? -39.216 -17.278 -28.124 1.00 62.02  ? 555 GLN   A CD  1 
ATOM   1127 O OE1 . GLN   A 1 182 ? -40.336 -16.758 -28.006 1.00 54.75  ? 555 GLN   A OE1 1 
ATOM   1128 N NE2 . GLN   A 1 182 ? -38.091 -16.592 -28.304 1.00 57.09  ? 555 GLN   A NE2 1 
ATOM   1129 N N   . PHE   A 1 183 ? -39.548 -21.682 -26.078 1.00 39.23  ? 556 PHE   A N   1 
ATOM   1130 C CA  . PHE   A 1 183 ? -40.891 -22.174 -25.817 1.00 38.82  ? 556 PHE   A CA  1 
ATOM   1131 C C   . PHE   A 1 183 ? -41.909 -21.042 -25.785 1.00 40.07  ? 556 PHE   A C   1 
ATOM   1132 O O   . PHE   A 1 183 ? -41.754 -20.075 -25.044 1.00 43.60  ? 556 PHE   A O   1 
ATOM   1133 C CB  . PHE   A 1 183 ? -40.974 -22.848 -24.459 1.00 38.39  ? 556 PHE   A CB  1 
ATOM   1134 C CG  . PHE   A 1 183 ? -40.099 -24.079 -24.362 1.00 37.24  ? 556 PHE   A CG  1 
ATOM   1135 C CD1 . PHE   A 1 183 ? -38.786 -23.979 -23.935 1.00 35.88  ? 556 PHE   A CD1 1 
ATOM   1136 C CD2 . PHE   A 1 183 ? -40.605 -25.319 -24.693 1.00 36.65  ? 556 PHE   A CD2 1 
ATOM   1137 C CE1 . PHE   A 1 183 ? -38.005 -25.108 -23.803 1.00 36.98  ? 556 PHE   A CE1 1 
ATOM   1138 C CE2 . PHE   A 1 183 ? -39.815 -26.438 -24.566 1.00 38.59  ? 556 PHE   A CE2 1 
ATOM   1139 C CZ  . PHE   A 1 183 ? -38.518 -26.329 -24.124 1.00 37.02  ? 556 PHE   A CZ  1 
ATOM   1140 N N   . SER   A 1 184 ? -42.973 -21.191 -26.575 1.00 37.62  ? 557 SER   A N   1 
ATOM   1141 C CA  . SER   A 1 184 ? -44.102 -20.282 -26.485 1.00 40.32  ? 557 SER   A CA  1 
ATOM   1142 C C   . SER   A 1 184 ? -44.719 -20.357 -25.083 1.00 38.07  ? 557 SER   A C   1 
ATOM   1143 O O   . SER   A 1 184 ? -44.848 -21.441 -24.520 1.00 33.51  ? 557 SER   A O   1 
ATOM   1144 C CB  . SER   A 1 184 ? -45.113 -20.609 -27.549 1.00 44.67  ? 557 SER   A CB  1 
ATOM   1145 O OG  . SER   A 1 184 ? -44.489 -20.698 -28.825 1.00 48.44  ? 557 SER   A OG  1 
ATOM   1146 N N   . LEU   A 1 185 ? -45.091 -19.194 -24.540 1.00 36.91  ? 558 LEU   A N   1 
ATOM   1147 C CA  . LEU   A 1 185 ? -45.739 -19.088 -23.240 1.00 39.03  ? 558 LEU   A CA  1 
ATOM   1148 C C   . LEU   A 1 185 ? -47.190 -18.644 -23.418 1.00 38.97  ? 558 LEU   A C   1 
ATOM   1149 O O   . LEU   A 1 185 ? -47.452 -17.629 -24.050 1.00 41.75  ? 558 LEU   A O   1 
ATOM   1150 C CB  . LEU   A 1 185 ? -44.937 -18.092 -22.402 1.00 36.60  ? 558 LEU   A CB  1 
ATOM   1151 C CG  . LEU   A 1 185 ? -43.452 -18.429 -22.237 1.00 37.08  ? 558 LEU   A CG  1 
ATOM   1152 C CD1 . LEU   A 1 185 ? -42.697 -17.381 -21.430 1.00 39.35  ? 558 LEU   A CD1 1 
ATOM   1153 C CD2 . LEU   A 1 185 ? -43.318 -19.800 -21.594 1.00 36.59  ? 558 LEU   A CD2 1 
ATOM   1154 N N   A ASP   A 1 186 ? -48.096 -19.414 -22.799 0.50 40.51  ? 559 ASP   A N   1 
ATOM   1155 N N   B ASP   A 1 186 ? -48.137 -19.421 -22.882 0.50 42.75  ? 559 ASP   A N   1 
ATOM   1156 C CA  A ASP   A 1 186 ? -49.537 -19.219 -22.815 0.50 43.05  ? 559 ASP   A CA  1 
ATOM   1157 C CA  B ASP   A 1 186 ? -49.536 -19.032 -22.968 0.50 46.84  ? 559 ASP   A CA  1 
ATOM   1158 C C   A ASP   A 1 186 ? -49.991 -18.575 -21.503 0.50 42.81  ? 559 ASP   A C   1 
ATOM   1159 C C   B ASP   A 1 186 ? -50.026 -18.600 -21.579 0.50 45.16  ? 559 ASP   A C   1 
ATOM   1160 O O   A ASP   A 1 186 ? -49.549 -18.993 -20.435 0.50 38.67  ? 559 ASP   A O   1 
ATOM   1161 O O   B ASP   A 1 186 ? -49.644 -19.180 -20.564 0.50 40.92  ? 559 ASP   A O   1 
ATOM   1162 C CB  A ASP   A 1 186 ? -50.241 -20.560 -22.960 0.50 43.29  ? 559 ASP   A CB  1 
ATOM   1163 C CB  B ASP   A 1 186 ? -50.363 -20.082 -23.701 0.50 50.51  ? 559 ASP   A CB  1 
ATOM   1164 C CG  A ASP   A 1 186 ? -51.752 -20.516 -22.791 0.50 44.67  ? 559 ASP   A CG  1 
ATOM   1165 C CG  B ASP   A 1 186 ? -50.504 -19.888 -25.211 0.50 52.86  ? 559 ASP   A CG  1 
ATOM   1166 O OD1 A ASP   A 1 186 ? -52.415 -19.970 -23.689 0.50 41.12  ? 559 ASP   A OD1 1 
ATOM   1167 O OD1 B ASP   A 1 186 ? -49.541 -20.186 -25.957 0.50 51.91  ? 559 ASP   A OD1 1 
ATOM   1168 O OD2 A ASP   A 1 186 ? -52.248 -21.006 -21.747 0.50 53.74  ? 559 ASP   A OD2 1 
ATOM   1169 O OD2 B ASP   A 1 186 ? -51.582 -19.422 -25.641 0.50 53.57  ? 559 ASP   A OD2 1 
ATOM   1170 N N   . PRO   A 1 187 ? -50.898 -17.567 -21.490 1.00 47.26  ? 560 PRO   A N   1 
ATOM   1171 C CA  . PRO   A 1 187 ? -51.485 -16.954 -22.693 1.00 50.44  ? 560 PRO   A CA  1 
ATOM   1172 C C   . PRO   A 1 187 ? -50.640 -15.900 -23.407 1.00 52.65  ? 560 PRO   A C   1 
ATOM   1173 O O   . PRO   A 1 187 ? -50.920 -15.552 -24.555 1.00 52.24  ? 560 PRO   A O   1 
ATOM   1174 C CB  . PRO   A 1 187 ? -52.782 -16.332 -22.109 1.00 50.34  ? 560 PRO   A CB  1 
ATOM   1175 C CG  . PRO   A 1 187 ? -52.373 -15.884 -20.717 1.00 50.04  ? 560 PRO   A CG  1 
ATOM   1176 C CD  . PRO   A 1 187 ? -51.409 -16.971 -20.238 1.00 47.96  ? 560 PRO   A CD  1 
ATOM   1177 N N   . GLU   A 1 188 ? -49.611 -15.406 -22.711 1.00 51.89  ? 561 GLU   A N   1 
ATOM   1178 C CA  . GLU   A 1 188 ? -48.816 -14.280 -23.165 1.00 54.34  ? 561 GLU   A CA  1 
ATOM   1179 C C   . GLU   A 1 188 ? -47.365 -14.503 -22.757 1.00 54.06  ? 561 GLU   A C   1 
ATOM   1180 O O   . GLU   A 1 188 ? -47.112 -15.139 -21.740 1.00 51.84  ? 561 GLU   A O   1 
ATOM   1181 C CB  . GLU   A 1 188 ? -49.170 -12.979 -22.439 1.00 56.62  ? 561 GLU   A CB  1 
ATOM   1182 C CG  . GLU   A 1 188 ? -50.292 -12.147 -23.051 1.00 65.28  ? 561 GLU   A CG  1 
ATOM   1183 C CD  . GLU   A 1 188 ? -50.302 -10.760 -22.421 1.00 76.80  ? 561 GLU   A CD  1 
ATOM   1184 O OE1 . GLU   A 1 188 ? -50.155 -9.752  -23.153 1.00 83.21  ? 561 GLU   A OE1 1 
ATOM   1185 O OE2 . GLU   A 1 188 ? -50.422 -10.692 -21.175 1.00 80.03  ? 561 GLU   A OE2 1 
ATOM   1186 N N   . PRO   A 1 189 ? -46.382 -13.933 -23.494 1.00 53.10  ? 562 PRO   A N   1 
ATOM   1187 C CA  . PRO   A 1 189 ? -45.015 -13.806 -22.993 1.00 47.50  ? 562 PRO   A CA  1 
ATOM   1188 C C   . PRO   A 1 189 ? -45.037 -13.279 -21.569 1.00 42.03  ? 562 PRO   A C   1 
ATOM   1189 O O   . PRO   A 1 189 ? -45.802 -12.378 -21.278 1.00 42.92  ? 562 PRO   A O   1 
ATOM   1190 C CB  . PRO   A 1 189 ? -44.401 -12.801 -23.990 1.00 43.94  ? 562 PRO   A CB  1 
ATOM   1191 C CG  . PRO   A 1 189 ? -45.075 -13.174 -25.288 1.00 46.20  ? 562 PRO   A CG  1 
ATOM   1192 C CD  . PRO   A 1 189 ? -46.521 -13.417 -24.867 1.00 50.23  ? 562 PRO   A CD  1 
ATOM   1193 N N   . ILE   A 1 190 ? -44.189 -13.831 -20.695 1.00 39.74  ? 563 ILE   A N   1 
ATOM   1194 C CA  . ILE   A 1 190 ? -44.170 -13.410 -19.305 1.00 37.38  ? 563 ILE   A CA  1 
ATOM   1195 C C   . ILE   A 1 190 ? -42.806 -13.751 -18.733 1.00 36.40  ? 563 ILE   A C   1 
ATOM   1196 O O   . ILE   A 1 190 ? -42.190 -14.726 -19.172 1.00 39.38  ? 563 ILE   A O   1 
ATOM   1197 C CB  . ILE   A 1 190 ? -45.323 -14.075 -18.526 1.00 35.52  ? 563 ILE   A CB  1 
ATOM   1198 C CG1 . ILE   A 1 190 ? -45.390 -13.624 -17.081 1.00 37.88  ? 563 ILE   A CG1 1 
ATOM   1199 C CG2 . ILE   A 1 190 ? -45.245 -15.591 -18.610 1.00 36.59  ? 563 ILE   A CG2 1 
ATOM   1200 C CD1 . ILE   A 1 190 ? -45.869 -12.200 -16.899 1.00 37.98  ? 563 ILE   A CD1 1 
ATOM   1201 N N   . ALA   A 1 191 ? -42.358 -12.940 -17.767 1.00 32.87  ? 564 ALA   A N   1 
ATOM   1202 C CA  . ALA   A 1 191 ? -41.080 -13.155 -17.109 1.00 33.63  ? 564 ALA   A CA  1 
ATOM   1203 C C   . ALA   A 1 191 ? -41.151 -14.446 -16.305 1.00 33.67  ? 564 ALA   A C   1 
ATOM   1204 O O   . ALA   A 1 191 ? -42.010 -14.586 -15.432 1.00 33.93  ? 564 ALA   A O   1 
ATOM   1205 C CB  . ALA   A 1 191 ? -40.728 -11.985 -16.204 1.00 33.39  ? 564 ALA   A CB  1 
ATOM   1206 N N   . ILE   A 1 192 ? -40.230 -15.363 -16.595 1.00 31.63  ? 565 ILE   A N   1 
ATOM   1207 C CA  . ILE   A 1 192 ? -40.074 -16.568 -15.791 1.00 34.57  ? 565 ILE   A CA  1 
ATOM   1208 C C   . ILE   A 1 192 ? -38.968 -16.365 -14.759 1.00 33.23  ? 565 ILE   A C   1 
ATOM   1209 O O   . ILE   A 1 192 ? -37.845 -15.979 -15.095 1.00 33.48  ? 565 ILE   A O   1 
ATOM   1210 C CB  . ILE   A 1 192 ? -39.851 -17.778 -16.706 1.00 35.36  ? 565 ILE   A CB  1 
ATOM   1211 C CG1 . ILE   A 1 192 ? -41.157 -18.077 -17.446 1.00 39.49  ? 565 ILE   A CG1 1 
ATOM   1212 C CG2 . ILE   A 1 192 ? -39.334 -18.992 -15.936 1.00 34.15  ? 565 ILE   A CG2 1 
ATOM   1213 C CD1 . ILE   A 1 192 ? -41.101 -19.263 -18.375 1.00 45.04  ? 565 ILE   A CD1 1 
ATOM   1214 N N   . ASN   A 1 193 ? -39.320 -16.604 -13.489 1.00 28.36  ? 566 ASN   A N   1 
ATOM   1215 C CA  . ASN   A 1 193 ? -38.446 -16.313 -12.369 1.00 28.98  ? 566 ASN   A CA  1 
ATOM   1216 C C   . ASN   A 1 193 ? -37.596 -17.509 -11.969 1.00 28.30  ? 566 ASN   A C   1 
ATOM   1217 O O   . ASN   A 1 193 ? -36.545 -17.315 -11.357 1.00 28.28  ? 566 ASN   A O   1 
ATOM   1218 C CB  . ASN   A 1 193 ? -39.241 -15.920 -11.130 1.00 30.64  ? 566 ASN   A CB  1 
ATOM   1219 C CG  . ASN   A 1 193 ? -39.947 -14.602 -11.302 1.00 32.44  ? 566 ASN   A CG  1 
ATOM   1220 O OD1 . ASN   A 1 193 ? -39.459 -13.740 -12.041 1.00 34.10  ? 566 ASN   A OD1 1 
ATOM   1221 N ND2 . ASN   A 1 193 ? -41.063 -14.410 -10.609 1.00 33.17  ? 566 ASN   A ND2 1 
ATOM   1222 N N   . CYS   A 1 194 ? -38.098 -18.727 -12.214 1.00 29.30  ? 567 CYS   A N   1 
ATOM   1223 C CA  . CYS   A 1 194 ? -37.472 -19.927 -11.666 1.00 30.24  ? 567 CYS   A CA  1 
ATOM   1224 C C   . CYS   A 1 194 ? -37.718 -21.112 -12.592 1.00 30.33  ? 567 CYS   A C   1 
ATOM   1225 O O   . CYS   A 1 194 ? -38.762 -21.187 -13.240 1.00 30.96  ? 567 CYS   A O   1 
ATOM   1226 C CB  . CYS   A 1 194 ? -37.961 -20.255 -10.258 1.00 29.84  ? 567 CYS   A CB  1 
ATOM   1227 S SG  . CYS   A 1 194 ? -39.766 -20.313 -10.094 1.00 34.48  ? 567 CYS   A SG  1 
ATOM   1228 N N   . THR   A 1 195 ? -36.734 -22.017 -12.617 1.00 30.88  ? 568 THR   A N   1 
ATOM   1229 C CA  . THR   A 1 195 ? -36.685 -23.163 -13.517 1.00 31.85  ? 568 THR   A CA  1 
ATOM   1230 C C   . THR   A 1 195 ? -36.071 -24.328 -12.749 1.00 32.44  ? 568 THR   A C   1 
ATOM   1231 O O   . THR   A 1 195 ? -35.188 -24.121 -11.920 1.00 32.37  ? 568 THR   A O   1 
ATOM   1232 C CB  . THR   A 1 195 ? -35.857 -22.852 -14.771 1.00 33.37  ? 568 THR   A CB  1 
ATOM   1233 O OG1 . THR   A 1 195 ? -34.561 -22.407 -14.367 1.00 33.02  ? 568 THR   A OG1 1 
ATOM   1234 C CG2 . THR   A 1 195 ? -36.501 -21.782 -15.631 1.00 33.48  ? 568 THR   A CG2 1 
ATOM   1235 N N   . ALA   A 1 196 ? -36.552 -25.547 -13.021 1.00 32.67  ? 569 ALA   A N   1 
ATOM   1236 C CA  . ALA   A 1 196 ? -35.903 -26.735 -12.491 1.00 32.39  ? 569 ALA   A CA  1 
ATOM   1237 C C   . ALA   A 1 196 ? -36.227 -27.937 -13.364 1.00 33.98  ? 569 ALA   A C   1 
ATOM   1238 O O   . ALA   A 1 196 ? -37.356 -28.101 -13.849 1.00 32.72  ? 569 ALA   A O   1 
ATOM   1239 C CB  . ALA   A 1 196 ? -36.295 -26.977 -11.044 1.00 32.27  ? 569 ALA   A CB  1 
ATOM   1240 N N   . PHE   A 1 197 ? -35.189 -28.752 -13.574 1.00 37.47  ? 570 PHE   A N   1 
ATOM   1241 C CA  . PHE   A 1 197 ? -35.313 -30.015 -14.285 1.00 36.64  ? 570 PHE   A CA  1 
ATOM   1242 C C   . PHE   A 1 197 ? -35.616 -31.122 -13.280 1.00 35.61  ? 570 PHE   A C   1 
ATOM   1243 O O   . PHE   A 1 197 ? -35.137 -31.079 -12.156 1.00 34.64  ? 570 PHE   A O   1 
ATOM   1244 C CB  . PHE   A 1 197 ? -34.017 -30.409 -15.013 1.00 37.43  ? 570 PHE   A CB  1 
ATOM   1245 C CG  . PHE   A 1 197 ? -33.751 -29.708 -16.336 1.00 35.38  ? 570 PHE   A CG  1 
ATOM   1246 C CD1 . PHE   A 1 197 ? -34.366 -30.133 -17.504 1.00 38.75  ? 570 PHE   A CD1 1 
ATOM   1247 C CD2 . PHE   A 1 197 ? -32.860 -28.645 -16.413 1.00 35.91  ? 570 PHE   A CD2 1 
ATOM   1248 C CE1 . PHE   A 1 197 ? -34.117 -29.489 -18.710 1.00 37.39  ? 570 PHE   A CE1 1 
ATOM   1249 C CE2 . PHE   A 1 197 ? -32.614 -28.017 -17.617 1.00 35.92  ? 570 PHE   A CE2 1 
ATOM   1250 C CZ  . PHE   A 1 197 ? -33.246 -28.433 -18.757 1.00 36.19  ? 570 PHE   A CZ  1 
ATOM   1251 N N   . ASN   A 1 198 ? -36.330 -32.155 -13.723 1.00 36.39  ? 571 ASN   A N   1 
ATOM   1252 C CA  . ASN   A 1 198 ? -36.409 -33.387 -12.955 1.00 39.16  ? 571 ASN   A CA  1 
ATOM   1253 C C   . ASN   A 1 198 ? -35.082 -34.143 -13.063 1.00 41.20  ? 571 ASN   A C   1 
ATOM   1254 O O   . ASN   A 1 198 ? -34.127 -33.640 -13.656 1.00 39.26  ? 571 ASN   A O   1 
ATOM   1255 C CB  . ASN   A 1 198 ? -37.618 -34.206 -13.377 1.00 36.54  ? 571 ASN   A CB  1 
ATOM   1256 C CG  . ASN   A 1 198 ? -37.465 -34.733 -14.780 1.00 41.46  ? 571 ASN   A CG  1 
ATOM   1257 O OD1 . ASN   A 1 198 ? -36.565 -34.293 -15.504 1.00 40.37  ? 571 ASN   A OD1 1 
ATOM   1258 N ND2 . ASN   A 1 198 ? -38.359 -35.623 -15.193 1.00 39.70  ? 571 ASN   A ND2 1 
ATOM   1259 N N   . HIS   A 1 199 ? -35.026 -35.346 -12.471 1.00 43.15  ? 572 HIS   A N   1 
ATOM   1260 C CA  . HIS   A 1 199 ? -33.780 -36.091 -12.329 1.00 47.66  ? 572 HIS   A CA  1 
ATOM   1261 C C   . HIS   A 1 199 ? -33.235 -36.518 -13.694 1.00 45.36  ? 572 HIS   A C   1 
ATOM   1262 O O   . HIS   A 1 199 ? -32.031 -36.436 -13.906 1.00 45.21  ? 572 HIS   A O   1 
ATOM   1263 C CB  . HIS   A 1 199 ? -33.920 -37.270 -11.351 1.00 52.46  ? 572 HIS   A CB  1 
ATOM   1264 C CG  . HIS   A 1 199 ? -32.616 -37.958 -11.020 1.00 66.30  ? 572 HIS   A CG  1 
ATOM   1265 N ND1 . HIS   A 1 199 ? -32.157 -39.087 -11.676 1.00 68.60  ? 572 HIS   A ND1 1 
ATOM   1266 C CD2 . HIS   A 1 199 ? -31.675 -37.675 -10.090 1.00 68.45  ? 572 HIS   A CD2 1 
ATOM   1267 C CE1 . HIS   A 1 199 ? -30.988 -39.461 -11.158 1.00 67.55  ? 572 HIS   A CE1 1 
ATOM   1268 N NE2 . HIS   A 1 199 ? -30.677 -38.619 -10.195 1.00 67.64  ? 572 HIS   A NE2 1 
ATOM   1269 N N   . ASN   A 1 200 ? -34.104 -36.966 -14.610 1.00 45.26  ? 573 ASN   A N   1 
ATOM   1270 C CA  . ASN   A 1 200 ? -33.664 -37.427 -15.923 1.00 55.38  ? 573 ASN   A CA  1 
ATOM   1271 C C   . ASN   A 1 200 ? -33.498 -36.266 -16.916 1.00 52.65  ? 573 ASN   A C   1 
ATOM   1272 O O   . ASN   A 1 200 ? -32.768 -36.390 -17.894 1.00 51.00  ? 573 ASN   A O   1 
ATOM   1273 C CB  . ASN   A 1 200 ? -34.605 -38.499 -16.459 1.00 59.91  ? 573 ASN   A CB  1 
ATOM   1274 C CG  . ASN   A 1 200 ? -34.531 -39.776 -15.651 1.00 72.37  ? 573 ASN   A CG  1 
ATOM   1275 O OD1 . ASN   A 1 200 ? -33.749 -39.874 -14.697 1.00 80.33  ? 573 ASN   A OD1 1 
ATOM   1276 N ND2 . ASN   A 1 200 ? -35.337 -40.769 -16.003 1.00 72.81  ? 573 ASN   A ND2 1 
ATOM   1277 N N   . GLY   A 1 201 ? -34.180 -35.139 -16.684 1.00 42.43  ? 574 GLY   A N   1 
ATOM   1278 C CA  . GLY   A 1 201 ? -34.069 -33.981 -17.556 1.00 38.23  ? 574 GLY   A CA  1 
ATOM   1279 C C   . GLY   A 1 201 ? -35.186 -33.929 -18.592 1.00 37.34  ? 574 GLY   A C   1 
ATOM   1280 O O   . GLY   A 1 201 ? -35.262 -32.995 -19.387 1.00 38.72  ? 574 GLY   A O   1 
ATOM   1281 N N   . ASN   A 1 202 ? -36.085 -34.915 -18.559 1.00 36.12  ? 575 ASN   A N   1 
ATOM   1282 C CA  . ASN   A 1 202 ? -37.162 -34.976 -19.529 1.00 39.44  ? 575 ASN   A CA  1 
ATOM   1283 C C   . ASN   A 1 202 ? -38.292 -34.010 -19.153 1.00 38.05  ? 575 ASN   A C   1 
ATOM   1284 O O   . ASN   A 1 202 ? -39.187 -33.767 -19.966 1.00 35.77  ? 575 ASN   A O   1 
ATOM   1285 C CB  . ASN   A 1 202 ? -37.612 -36.421 -19.715 1.00 47.32  ? 575 ASN   A CB  1 
ATOM   1286 C CG  . ASN   A 1 202 ? -38.074 -37.054 -18.421 1.00 58.86  ? 575 ASN   A CG  1 
ATOM   1287 O OD1 . ASN   A 1 202 ? -37.291 -37.180 -17.463 1.00 60.05  ? 575 ASN   A OD1 1 
ATOM   1288 N ND2 . ASN   A 1 202 ? -39.334 -37.464 -18.373 1.00 63.14  ? 575 ASN   A ND2 1 
ATOM   1289 N N   . LEU   A 1 203 ? -38.281 -33.467 -17.920 1.00 35.27  ? 576 LEU   A N   1 
ATOM   1290 C CA  . LEU   A 1 203 ? -39.262 -32.457 -17.547 1.00 36.06  ? 576 LEU   A CA  1 
ATOM   1291 C C   . LEU   A 1 203 ? -38.555 -31.236 -16.976 1.00 34.74  ? 576 LEU   A C   1 
ATOM   1292 O O   . LEU   A 1 203 ? -37.494 -31.337 -16.356 1.00 35.91  ? 576 LEU   A O   1 
ATOM   1293 C CB  . LEU   A 1 203 ? -40.283 -32.969 -16.533 1.00 39.40  ? 576 LEU   A CB  1 
ATOM   1294 C CG  . LEU   A 1 203 ? -41.137 -34.167 -16.948 1.00 40.65  ? 576 LEU   A CG  1 
ATOM   1295 C CD1 . LEU   A 1 203 ? -41.891 -34.641 -15.706 1.00 41.20  ? 576 LEU   A CD1 1 
ATOM   1296 C CD2 . LEU   A 1 203 ? -42.098 -33.848 -18.080 1.00 41.85  ? 576 LEU   A CD2 1 
ATOM   1297 N N   . LEU   A 1 204 ? -39.190 -30.086 -17.208 1.00 33.47  ? 577 LEU   A N   1 
ATOM   1298 C CA  . LEU   A 1 204 ? -38.732 -28.805 -16.716 1.00 34.71  ? 577 LEU   A CA  1 
ATOM   1299 C C   . LEU   A 1 204 ? -39.941 -28.085 -16.135 1.00 31.96  ? 577 LEU   A C   1 
ATOM   1300 O O   . LEU   A 1 204 ? -40.940 -27.857 -16.830 1.00 33.83  ? 577 LEU   A O   1 
ATOM   1301 C CB  . LEU   A 1 204 ? -38.108 -27.947 -17.818 1.00 32.52  ? 577 LEU   A CB  1 
ATOM   1302 C CG  . LEU   A 1 204 ? -37.699 -26.538 -17.376 1.00 32.29  ? 577 LEU   A CG  1 
ATOM   1303 C CD1 . LEU   A 1 204 ? -36.355 -26.595 -16.685 1.00 32.61  ? 577 LEU   A CD1 1 
ATOM   1304 C CD2 . LEU   A 1 204 ? -37.660 -25.526 -18.506 1.00 33.88  ? 577 LEU   A CD2 1 
ATOM   1305 N N   . VAL   A 1 205 ? -39.826 -27.682 -14.872 1.00 30.66  ? 578 VAL   A N   1 
ATOM   1306 C CA  . VAL   A 1 205 ? -40.909 -26.949 -14.253 1.00 30.17  ? 578 VAL   A CA  1 
ATOM   1307 C C   . VAL   A 1 205 ? -40.456 -25.499 -14.097 1.00 29.73  ? 578 VAL   A C   1 
ATOM   1308 O O   . VAL   A 1 205 ? -39.308 -25.272 -13.753 1.00 27.90  ? 578 VAL   A O   1 
ATOM   1309 C CB  . VAL   A 1 205 ? -41.316 -27.605 -12.926 1.00 32.10  ? 578 VAL   A CB  1 
ATOM   1310 C CG1 . VAL   A 1 205 ? -40.251 -27.467 -11.849 1.00 33.35  ? 578 VAL   A CG1 1 
ATOM   1311 C CG2 . VAL   A 1 205 ? -42.639 -27.059 -12.429 1.00 34.54  ? 578 VAL   A CG2 1 
ATOM   1312 N N   . THR   A 1 206 ? -41.370 -24.551 -14.359 1.00 28.79  ? 579 THR   A N   1 
ATOM   1313 C CA  . THR   A 1 206 ? -41.091 -23.130 -14.292 1.00 29.83  ? 579 THR   A CA  1 
ATOM   1314 C C   . THR   A 1 206 ? -42.184 -22.433 -13.478 1.00 31.69  ? 579 THR   A C   1 
ATOM   1315 O O   . THR   A 1 206 ? -43.322 -22.896 -13.441 1.00 28.85  ? 579 THR   A O   1 
ATOM   1316 C CB  . THR   A 1 206 ? -41.030 -22.596 -15.721 1.00 31.24  ? 579 THR   A CB  1 
ATOM   1317 O OG1 . THR   A 1 206 ? -42.374 -22.674 -16.197 1.00 30.59  ? 579 THR   A OG1 1 
ATOM   1318 C CG2 . THR   A 1 206 ? -40.107 -23.424 -16.606 1.00 30.84  ? 579 THR   A CG2 1 
ATOM   1319 N N   . GLY   A 1 207 ? -41.813 -21.311 -12.841 1.00 30.06  ? 580 GLY   A N   1 
ATOM   1320 C CA  . GLY   A 1 207 ? -42.754 -20.383 -12.239 1.00 29.40  ? 580 GLY   A CA  1 
ATOM   1321 C C   . GLY   A 1 207 ? -42.487 -18.971 -12.746 1.00 30.89  ? 580 GLY   A C   1 
ATOM   1322 O O   . GLY   A 1 207 ? -41.339 -18.598 -12.975 1.00 31.38  ? 580 GLY   A O   1 
ATOM   1323 N N   . ALA   A 1 208 ? -43.558 -18.203 -12.925 1.00 31.25  ? 581 ALA   A N   1 
ATOM   1324 C CA  . ALA   A 1 208 ? -43.480 -16.931 -13.625 1.00 32.74  ? 581 ALA   A CA  1 
ATOM   1325 C C   . ALA   A 1 208 ? -44.098 -15.812 -12.792 1.00 33.29  ? 581 ALA   A C   1 
ATOM   1326 O O   . ALA   A 1 208 ? -44.734 -16.044 -11.765 1.00 33.42  ? 581 ALA   A O   1 
ATOM   1327 C CB  . ALA   A 1 208 ? -44.174 -17.048 -14.956 1.00 33.86  ? 581 ALA   A CB  1 
ATOM   1328 N N   . ALA   A 1 209 ? -43.917 -14.591 -13.289 1.00 33.20  ? 582 ALA   A N   1 
ATOM   1329 C CA  . ALA   A 1 209 ? -44.395 -13.400 -12.616 1.00 36.18  ? 582 ALA   A CA  1 
ATOM   1330 C C   . ALA   A 1 209 ? -45.919 -13.329 -12.627 1.00 34.46  ? 582 ALA   A C   1 
ATOM   1331 O O   . ALA   A 1 209 ? -46.477 -12.596 -11.837 1.00 36.15  ? 582 ALA   A O   1 
ATOM   1332 C CB  . ALA   A 1 209 ? -43.796 -12.169 -13.266 1.00 36.51  ? 582 ALA   A CB  1 
ATOM   1333 N N   . ASP   A 1 210 ? -46.587 -14.075 -13.513 1.00 34.13  ? 583 ASP   A N   1 
ATOM   1334 C CA  . ASP   A 1 210 ? -48.044 -14.049 -13.578 1.00 34.59  ? 583 ASP   A CA  1 
ATOM   1335 C C   . ASP   A 1 210 ? -48.653 -15.046 -12.587 1.00 36.70  ? 583 ASP   A C   1 
ATOM   1336 O O   . ASP   A 1 210 ? -49.864 -15.233 -12.575 1.00 39.56  ? 583 ASP   A O   1 
ATOM   1337 C CB  . ASP   A 1 210 ? -48.526 -14.310 -14.996 1.00 34.63  ? 583 ASP   A CB  1 
ATOM   1338 C CG  . ASP   A 1 210 ? -48.161 -15.672 -15.564 1.00 35.54  ? 583 ASP   A CG  1 
ATOM   1339 O OD1 . ASP   A 1 210 ? -47.395 -16.393 -14.892 1.00 37.86  ? 583 ASP   A OD1 1 
ATOM   1340 O OD2 . ASP   A 1 210 ? -48.661 -16.013 -16.660 1.00 35.35  ? 583 ASP   A OD2 1 
ATOM   1341 N N   . GLY   A 1 211 ? -47.810 -15.710 -11.785 1.00 34.82  ? 584 GLY   A N   1 
ATOM   1342 C CA  . GLY   A 1 211 ? -48.263 -16.649 -10.769 1.00 36.62  ? 584 GLY   A CA  1 
ATOM   1343 C C   . GLY   A 1 211 ? -48.535 -18.053 -11.308 1.00 35.52  ? 584 GLY   A C   1 
ATOM   1344 O O   . GLY   A 1 211 ? -49.018 -18.918 -10.570 1.00 34.36  ? 584 GLY   A O   1 
ATOM   1345 N N   . VAL   A 1 212 ? -48.193 -18.288 -12.578 1.00 34.13  ? 585 VAL   A N   1 
ATOM   1346 C CA  . VAL   A 1 212 ? -48.495 -19.551 -13.229 1.00 33.63  ? 585 VAL   A CA  1 
ATOM   1347 C C   . VAL   A 1 212 ? -47.244 -20.420 -13.271 1.00 35.31  ? 585 VAL   A C   1 
ATOM   1348 O O   . VAL   A 1 212 ? -46.135 -19.933 -13.523 1.00 32.29  ? 585 VAL   A O   1 
ATOM   1349 C CB  . VAL   A 1 212 ? -49.050 -19.333 -14.645 1.00 35.83  ? 585 VAL   A CB  1 
ATOM   1350 C CG1 . VAL   A 1 212 ? -49.264 -20.650 -15.391 1.00 39.48  ? 585 VAL   A CG1 1 
ATOM   1351 C CG2 . VAL   A 1 212 ? -50.333 -18.529 -14.604 1.00 34.18  ? 585 VAL   A CG2 1 
ATOM   1352 N N   . ILE   A 1 213 ? -47.454 -21.709 -12.972 1.00 33.79  ? 586 ILE   A N   1 
ATOM   1353 C CA  . ILE   A 1 213 ? -46.443 -22.738 -13.114 1.00 33.02  ? 586 ILE   A CA  1 
ATOM   1354 C C   . ILE   A 1 213 ? -46.693 -23.418 -14.450 1.00 35.44  ? 586 ILE   A C   1 
ATOM   1355 O O   . ILE   A 1 213 ? -47.839 -23.680 -14.805 1.00 34.67  ? 586 ILE   A O   1 
ATOM   1356 C CB  . ILE   A 1 213 ? -46.496 -23.730 -11.941 1.00 35.01  ? 586 ILE   A CB  1 
ATOM   1357 C CG1 . ILE   A 1 213 ? -46.101 -23.038 -10.648 1.00 35.56  ? 586 ILE   A CG1 1 
ATOM   1358 C CG2 . ILE   A 1 213 ? -45.650 -24.974 -12.209 1.00 35.41  ? 586 ILE   A CG2 1 
ATOM   1359 C CD1 . ILE   A 1 213 ? -46.047 -23.947 -9.440  1.00 36.84  ? 586 ILE   A CD1 1 
ATOM   1360 N N   . ARG   A 1 214 ? -45.608 -23.660 -15.188 1.00 34.49  ? 587 ARG   A N   1 
ATOM   1361 C CA  . ARG   A 1 214 ? -45.672 -24.313 -16.480 1.00 32.71  ? 587 ARG   A CA  1 
ATOM   1362 C C   . ARG   A 1 214 ? -44.640 -25.425 -16.477 1.00 32.58  ? 587 ARG   A C   1 
ATOM   1363 O O   . ARG   A 1 214 ? -43.474 -25.200 -16.147 1.00 32.97  ? 587 ARG   A O   1 
ATOM   1364 C CB  . ARG   A 1 214 ? -45.408 -23.311 -17.602 1.00 33.80  ? 587 ARG   A CB  1 
ATOM   1365 C CG  . ARG   A 1 214 ? -46.409 -22.167 -17.679 1.00 35.45  ? 587 ARG   A CG  1 
ATOM   1366 C CD  . ARG   A 1 214 ? -45.955 -21.124 -18.674 1.00 35.72  ? 587 ARG   A CD  1 
ATOM   1367 N NE  . ARG   A 1 214 ? -46.943 -20.058 -18.841 1.00 38.00  ? 587 ARG   A NE  1 
ATOM   1368 C CZ  . ARG   A 1 214 ? -47.099 -19.033 -18.006 1.00 38.67  ? 587 ARG   A CZ  1 
ATOM   1369 N NH1 . ARG   A 1 214 ? -46.254 -18.872 -16.985 1.00 36.32  ? 587 ARG   A NH1 1 
ATOM   1370 N NH2 . ARG   A 1 214 ? -48.079 -18.160 -18.225 1.00 33.88  ? 587 ARG   A NH2 1 
ATOM   1371 N N   . LEU   A 1 215 ? -45.123 -26.632 -16.766 1.00 33.69  ? 588 LEU   A N   1 
ATOM   1372 C CA  . LEU   A 1 215 ? -44.296 -27.815 -16.801 1.00 35.86  ? 588 LEU   A CA  1 
ATOM   1373 C C   . LEU   A 1 215 ? -44.068 -28.216 -18.263 1.00 37.71  ? 588 LEU   A C   1 
ATOM   1374 O O   . LEU   A 1 215 ? -45.015 -28.503 -18.998 1.00 36.41  ? 588 LEU   A O   1 
ATOM   1375 C CB  . LEU   A 1 215 ? -45.000 -28.904 -16.001 1.00 37.09  ? 588 LEU   A CB  1 
ATOM   1376 C CG  . LEU   A 1 215 ? -44.312 -30.268 -15.994 1.00 41.33  ? 588 LEU   A CG  1 
ATOM   1377 C CD1 . LEU   A 1 215 ? -43.216 -30.257 -14.954 1.00 42.74  ? 588 LEU   A CD1 1 
ATOM   1378 C CD2 . LEU   A 1 215 ? -45.321 -31.368 -15.759 1.00 44.95  ? 588 LEU   A CD2 1 
ATOM   1379 N N   . PHE   A 1 216 ? -42.792 -28.295 -18.656 1.00 35.52  ? 589 PHE   A N   1 
ATOM   1380 C CA  . PHE   A 1 216 ? -42.441 -28.562 -20.045 1.00 37.75  ? 589 PHE   A CA  1 
ATOM   1381 C C   . PHE   A 1 216 ? -41.933 -29.988 -20.208 1.00 33.47  ? 589 PHE   A C   1 
ATOM   1382 O O   . PHE   A 1 216 ? -41.099 -30.450 -19.438 1.00 38.62  ? 589 PHE   A O   1 
ATOM   1383 C CB  . PHE   A 1 216 ? -41.405 -27.544 -20.528 1.00 34.76  ? 589 PHE   A CB  1 
ATOM   1384 C CG  . PHE   A 1 216 ? -42.011 -26.160 -20.668 1.00 30.81  ? 589 PHE   A CG  1 
ATOM   1385 C CD1 . PHE   A 1 216 ? -42.699 -25.804 -21.818 1.00 33.81  ? 589 PHE   A CD1 1 
ATOM   1386 C CD2 . PHE   A 1 216 ? -41.933 -25.242 -19.629 1.00 32.85  ? 589 PHE   A CD2 1 
ATOM   1387 C CE1 . PHE   A 1 216 ? -43.274 -24.548 -21.936 1.00 35.35  ? 589 PHE   A CE1 1 
ATOM   1388 C CE2 . PHE   A 1 216 ? -42.493 -23.979 -19.750 1.00 31.44  ? 589 PHE   A CE2 1 
ATOM   1389 C CZ  . PHE   A 1 216 ? -43.157 -23.631 -20.903 1.00 35.42  ? 589 PHE   A CZ  1 
ATOM   1390 N N   . ASP   A 1 217 ? -42.488 -30.675 -21.208 1.00 37.16  ? 590 ASP   A N   1 
ATOM   1391 C CA  . ASP   A 1 217 ? -41.946 -31.914 -21.741 1.00 39.15  ? 590 ASP   A CA  1 
ATOM   1392 C C   . ASP   A 1 217 ? -40.763 -31.550 -22.633 1.00 37.43  ? 590 ASP   A C   1 
ATOM   1393 O O   . ASP   A 1 217 ? -40.934 -30.875 -23.637 1.00 37.51  ? 590 ASP   A O   1 
ATOM   1394 C CB  . ASP   A 1 217 ? -43.026 -32.658 -22.510 1.00 43.03  ? 590 ASP   A CB  1 
ATOM   1395 C CG  . ASP   A 1 217 ? -42.626 -33.988 -23.136 1.00 46.20  ? 590 ASP   A CG  1 
ATOM   1396 O OD1 . ASP   A 1 217 ? -41.409 -34.252 -23.263 1.00 47.82  ? 590 ASP   A OD1 1 
ATOM   1397 O OD2 . ASP   A 1 217 ? -43.542 -34.761 -23.460 1.00 51.63  ? 590 ASP   A OD2 1 
ATOM   1398 N N   . MET   A 1 218 ? -39.558 -31.954 -22.238 1.00 40.61  ? 591 MET   A N   1 
ATOM   1399 C CA  . MET   A 1 218 ? -38.346 -31.497 -22.905 1.00 41.41  ? 591 MET   A CA  1 
ATOM   1400 C C   . MET   A 1 218 ? -37.931 -32.434 -24.044 1.00 42.69  ? 591 MET   A C   1 
ATOM   1401 O O   . MET   A 1 218 ? -36.880 -32.227 -24.645 1.00 41.70  ? 591 MET   A O   1 
ATOM   1402 C CB  . MET   A 1 218 ? -37.221 -31.362 -21.876 1.00 41.54  ? 591 MET   A CB  1 
ATOM   1403 C CG  . MET   A 1 218 ? -37.572 -30.387 -20.766 1.00 40.61  ? 591 MET   A CG  1 
ATOM   1404 S SD  . MET   A 1 218 ? -37.908 -28.743 -21.425 1.00 38.00  ? 591 MET   A SD  1 
ATOM   1405 C CE  . MET   A 1 218 ? -36.220 -28.129 -21.485 1.00 40.38  ? 591 MET   A CE  1 
ATOM   1406 N N   . GLN   A 1 219 ? -38.763 -33.443 -24.343 1.00 45.45  ? 592 GLN   A N   1 
ATOM   1407 C CA  . GLN   A 1 219 ? -38.556 -34.331 -25.478 1.00 51.46  ? 592 GLN   A CA  1 
ATOM   1408 C C   . GLN   A 1 219 ? -39.401 -33.859 -26.661 1.00 50.82  ? 592 GLN   A C   1 
ATOM   1409 O O   . GLN   A 1 219 ? -38.915 -33.857 -27.789 1.00 50.85  ? 592 GLN   A O   1 
ATOM   1410 C CB  . GLN   A 1 219 ? -38.860 -35.779 -25.091 1.00 52.94  ? 592 GLN   A CB  1 
ATOM   1411 C CG  . GLN   A 1 219 ? -37.831 -36.381 -24.137 1.00 58.04  ? 592 GLN   A CG  1 
ATOM   1412 C CD  . GLN   A 1 219 ? -38.222 -37.741 -23.590 1.00 66.32  ? 592 GLN   A CD  1 
ATOM   1413 O OE1 . GLN   A 1 219 ? -39.385 -38.002 -23.257 1.00 72.11  ? 592 GLN   A OE1 1 
ATOM   1414 N NE2 . GLN   A 1 219 ? -37.243 -38.628 -23.482 1.00 65.28  ? 592 GLN   A NE2 1 
ATOM   1415 N N   . GLN   A 1 220 ? -40.657 -33.473 -26.381 1.00 48.33  ? 593 GLN   A N   1 
ATOM   1416 C CA  . GLN   A 1 220 ? -41.590 -32.973 -27.380 1.00 44.67  ? 593 GLN   A CA  1 
ATOM   1417 C C   . GLN   A 1 220 ? -41.513 -31.453 -27.491 1.00 43.09  ? 593 GLN   A C   1 
ATOM   1418 O O   . GLN   A 1 220 ? -42.141 -30.870 -28.372 1.00 42.30  ? 593 GLN   A O   1 
ATOM   1419 C CB  . GLN   A 1 220 ? -43.019 -33.340 -26.977 1.00 53.43  ? 593 GLN   A CB  1 
ATOM   1420 C CG  . GLN   A 1 220 ? -43.265 -34.838 -26.814 1.00 60.34  ? 593 GLN   A CG  1 
ATOM   1421 C CD  . GLN   A 1 220 ? -43.133 -35.593 -28.118 1.00 66.28  ? 593 GLN   A CD  1 
ATOM   1422 O OE1 . GLN   A 1 220 ? -43.763 -35.244 -29.122 1.00 70.06  ? 593 GLN   A OE1 1 
ATOM   1423 N NE2 . GLN   A 1 220 ? -42.290 -36.615 -28.125 1.00 71.89  ? 593 GLN   A NE2 1 
ATOM   1424 N N   . HIS   A 1 221 ? -40.771 -30.813 -26.575 1.00 40.19  ? 594 HIS   A N   1 
ATOM   1425 C CA  . HIS   A 1 221 ? -40.685 -29.366 -26.512 1.00 38.88  ? 594 HIS   A CA  1 
ATOM   1426 C C   . HIS   A 1 221 ? -42.069 -28.731 -26.478 1.00 42.29  ? 594 HIS   A C   1 
ATOM   1427 O O   . HIS   A 1 221 ? -42.344 -27.841 -27.273 1.00 43.58  ? 594 HIS   A O   1 
ATOM   1428 C CB  . HIS   A 1 221 ? -39.856 -28.798 -27.674 1.00 41.09  ? 594 HIS   A CB  1 
ATOM   1429 C CG  . HIS   A 1 221 ? -38.523 -29.452 -27.784 1.00 38.61  ? 594 HIS   A CG  1 
ATOM   1430 N ND1 . HIS   A 1 221 ? -37.551 -29.278 -26.826 1.00 46.37  ? 594 HIS   A ND1 1 
ATOM   1431 C CD2 . HIS   A 1 221 ? -38.027 -30.330 -28.640 1.00 39.87  ? 594 HIS   A CD2 1 
ATOM   1432 C CE1 . HIS   A 1 221 ? -36.490 -30.016 -27.134 1.00 44.22  ? 594 HIS   A CE1 1 
ATOM   1433 N NE2 . HIS   A 1 221 ? -36.759 -30.666 -28.238 1.00 42.36  ? 594 HIS   A NE2 1 
ATOM   1434 N N   . GLU   A 1 222 ? -42.922 -29.151 -25.535 1.00 45.95  ? 595 GLU   A N   1 
ATOM   1435 C CA  . GLU   A 1 222 ? -44.210 -28.486 -25.343 1.00 50.48  ? 595 GLU   A CA  1 
ATOM   1436 C C   . GLU   A 1 222 ? -44.567 -28.398 -23.859 1.00 41.64  ? 595 GLU   A C   1 
ATOM   1437 O O   . GLU   A 1 222 ? -44.083 -29.177 -23.043 1.00 40.34  ? 595 GLU   A O   1 
ATOM   1438 C CB  . GLU   A 1 222 ? -45.353 -29.191 -26.075 1.00 54.85  ? 595 GLU   A CB  1 
ATOM   1439 C CG  . GLU   A 1 222 ? -45.418 -30.696 -25.824 1.00 59.33  ? 595 GLU   A CG  1 
ATOM   1440 C CD  . GLU   A 1 222 ? -46.513 -31.443 -26.580 1.00 61.82  ? 595 GLU   A CD  1 
ATOM   1441 O OE1 . GLU   A 1 222 ? -47.346 -30.795 -27.248 1.00 71.89  ? 595 GLU   A OE1 1 
ATOM   1442 O OE2 . GLU   A 1 222 ? -46.549 -32.687 -26.487 1.00 63.32  ? 595 GLU   A OE2 1 
ATOM   1443 N N   . CYS   A 1 223 ? -45.449 -27.451 -23.541 1.00 37.48  ? 596 CYS   A N   1 
ATOM   1444 C CA  . CYS   A 1 223 ? -46.056 -27.362 -22.227 1.00 42.40  ? 596 CYS   A CA  1 
ATOM   1445 C C   . CYS   A 1 223 ? -46.991 -28.552 -22.009 1.00 41.39  ? 596 CYS   A C   1 
ATOM   1446 O O   . CYS   A 1 223 ? -48.024 -28.655 -22.659 1.00 38.56  ? 596 CYS   A O   1 
ATOM   1447 C CB  . CYS   A 1 223 ? -46.809 -26.047 -22.048 1.00 43.71  ? 596 CYS   A CB  1 
ATOM   1448 S SG  . CYS   A 1 223 ? -47.408 -25.817 -20.349 1.00 43.50  ? 596 CYS   A SG  1 
ATOM   1449 N N   . ALA   A 1 224 ? -46.602 -29.465 -21.114 1.00 38.11  ? 597 ALA   A N   1 
ATOM   1450 C CA  . ALA   A 1 224 ? -47.434 -30.611 -20.796 1.00 42.12  ? 597 ALA   A CA  1 
ATOM   1451 C C   . ALA   A 1 224 ? -48.571 -30.210 -19.855 1.00 47.08  ? 597 ALA   A C   1 
ATOM   1452 O O   . ALA   A 1 224 ? -49.610 -30.860 -19.830 1.00 45.26  ? 597 ALA   A O   1 
ATOM   1453 C CB  . ALA   A 1 224 ? -46.602 -31.706 -20.176 1.00 40.88  ? 597 ALA   A CB  1 
ATOM   1454 N N   . MET   A 1 225 ? -48.382 -29.130 -19.087 1.00 45.97  ? 598 MET   A N   1 
ATOM   1455 C CA  . MET   A 1 225 ? -49.259 -28.852 -17.965 1.00 45.25  ? 598 MET   A CA  1 
ATOM   1456 C C   . MET   A 1 225 ? -48.972 -27.443 -17.465 1.00 41.97  ? 598 MET   A C   1 
ATOM   1457 O O   . MET   A 1 225 ? -47.811 -27.065 -17.303 1.00 40.78  ? 598 MET   A O   1 
ATOM   1458 C CB  . MET   A 1 225 ? -48.939 -29.845 -16.844 1.00 50.97  ? 598 MET   A CB  1 
ATOM   1459 C CG  . MET   A 1 225 ? -50.103 -30.336 -16.043 1.00 59.79  ? 598 MET   A CG  1 
ATOM   1460 S SD  . MET   A 1 225 ? -49.540 -31.709 -15.011 1.00 61.27  ? 598 MET   A SD  1 
ATOM   1461 C CE  . MET   A 1 225 ? -50.010 -33.085 -16.068 1.00 61.90  ? 598 MET   A CE  1 
ATOM   1462 N N   . SER   A 1 226 ? -50.028 -26.687 -17.180 1.00 40.28  ? 599 SER   A N   1 
ATOM   1463 C CA  . SER   A 1 226 ? -49.861 -25.420 -16.495 1.00 42.31  ? 599 SER   A CA  1 
ATOM   1464 C C   . SER   A 1 226 ? -51.077 -25.100 -15.625 1.00 39.96  ? 599 SER   A C   1 
ATOM   1465 O O   . SER   A 1 226 ? -52.199 -25.488 -15.934 1.00 38.19  ? 599 SER   A O   1 
ATOM   1466 C CB  . SER   A 1 226 ? -49.610 -24.340 -17.490 1.00 38.63  ? 599 SER   A CB  1 
ATOM   1467 O OG  . SER   A 1 226 ? -50.812 -24.056 -18.175 1.00 39.71  ? 599 SER   A OG  1 
ATOM   1468 N N   . TRP   A 1 227 ? -50.840 -24.352 -14.547 1.00 40.69  ? 600 TRP   A N   1 
ATOM   1469 C CA  . TRP   A 1 227 ? -51.901 -23.980 -13.626 1.00 38.98  ? 600 TRP   A CA  1 
ATOM   1470 C C   . TRP   A 1 227 ? -51.501 -22.719 -12.877 1.00 42.06  ? 600 TRP   A C   1 
ATOM   1471 O O   . TRP   A 1 227 ? -50.309 -22.434 -12.702 1.00 39.79  ? 600 TRP   A O   1 
ATOM   1472 C CB  . TRP   A 1 227 ? -52.205 -25.121 -12.647 1.00 36.48  ? 600 TRP   A CB  1 
ATOM   1473 C CG  . TRP   A 1 227 ? -51.050 -25.451 -11.739 1.00 35.00  ? 600 TRP   A CG  1 
ATOM   1474 C CD1 . TRP   A 1 227 ? -50.789 -24.890 -10.522 1.00 35.87  ? 600 TRP   A CD1 1 
ATOM   1475 C CD2 . TRP   A 1 227 ? -50.004 -26.415 -11.967 1.00 36.89  ? 600 TRP   A CD2 1 
ATOM   1476 N NE1 . TRP   A 1 227 ? -49.650 -25.422 -9.986  1.00 35.37  ? 600 TRP   A NE1 1 
ATOM   1477 C CE2 . TRP   A 1 227 ? -49.143 -26.357 -10.849 1.00 35.62  ? 600 TRP   A CE2 1 
ATOM   1478 C CE3 . TRP   A 1 227 ? -49.708 -27.320 -12.991 1.00 36.84  ? 600 TRP   A CE3 1 
ATOM   1479 C CZ2 . TRP   A 1 227 ? -48.019 -27.168 -10.735 1.00 36.23  ? 600 TRP   A CZ2 1 
ATOM   1480 C CZ3 . TRP   A 1 227 ? -48.595 -28.125 -12.873 1.00 35.25  ? 600 TRP   A CZ3 1 
ATOM   1481 C CH2 . TRP   A 1 227 ? -47.759 -28.044 -11.765 1.00 35.78  ? 600 TRP   A CH2 1 
ATOM   1482 N N   . ARG   A 1 228 ? -52.532 -21.975 -12.469 1.00 41.36  ? 601 ARG   A N   1 
ATOM   1483 C CA  . ARG   A 1 228 ? -52.383 -20.845 -11.576 1.00 42.91  ? 601 ARG   A CA  1 
ATOM   1484 C C   . ARG   A 1 228 ? -51.949 -21.363 -10.211 1.00 38.04  ? 601 ARG   A C   1 
ATOM   1485 O O   . ARG   A 1 228 ? -52.645 -22.153 -9.597  1.00 40.01  ? 601 ARG   A O   1 
ATOM   1486 C CB  . ARG   A 1 228 ? -53.735 -20.130 -11.511 1.00 50.91  ? 601 ARG   A CB  1 
ATOM   1487 C CG  . ARG   A 1 228 ? -53.676 -18.797 -10.782 1.00 63.41  ? 601 ARG   A CG  1 
ATOM   1488 C CD  . ARG   A 1 228 ? -53.210 -17.658 -11.676 1.00 73.90  ? 601 ARG   A CD  1 
ATOM   1489 N NE  . ARG   A 1 228 ? -52.890 -16.450 -10.907 1.00 85.21  ? 601 ARG   A NE  1 
ATOM   1490 C CZ  . ARG   A 1 228 ? -53.683 -15.840 -10.024 1.00 94.18  ? 601 ARG   A CZ  1 
ATOM   1491 N NH1 . ARG   A 1 228 ? -54.873 -16.330 -9.714  1.00 94.95  ? 601 ARG   A NH1 1 
ATOM   1492 N NH2 . ARG   A 1 228 ? -53.271 -14.726 -9.442  1.00 93.26  ? 601 ARG   A NH2 1 
ATOM   1493 N N   . ALA   A 1 229 ? -50.790 -20.915 -9.737  1.00 36.41  ? 602 ALA   A N   1 
ATOM   1494 C CA  . ALA   A 1 229 ? -50.211 -21.477 -8.537  1.00 36.29  ? 602 ALA   A CA  1 
ATOM   1495 C C   . ALA   A 1 229 ? -50.343 -20.517 -7.363  1.00 38.64  ? 602 ALA   A C   1 
ATOM   1496 O O   . ALA   A 1 229 ? -50.659 -20.948 -6.256  1.00 34.43  ? 602 ALA   A O   1 
ATOM   1497 C CB  . ALA   A 1 229 ? -48.767 -21.818 -8.774  1.00 36.66  ? 602 ALA   A CB  1 
ATOM   1498 N N   . HIS   A 1 230 ? -50.020 -19.242 -7.613  1.00 38.84  ? 603 HIS   A N   1 
ATOM   1499 C CA  . HIS   A 1 230 ? -49.960 -18.239 -6.566  1.00 38.70  ? 603 HIS   A CA  1 
ATOM   1500 C C   . HIS   A 1 230 ? -50.677 -16.972 -7.008  1.00 41.73  ? 603 HIS   A C   1 
ATOM   1501 O O   . HIS   A 1 230 ? -50.793 -16.696 -8.199  1.00 40.73  ? 603 HIS   A O   1 
ATOM   1502 C CB  . HIS   A 1 230 ? -48.513 -17.879 -6.217  1.00 34.19  ? 603 HIS   A CB  1 
ATOM   1503 C CG  . HIS   A 1 230 ? -47.783 -19.021 -5.632  1.00 34.81  ? 603 HIS   A CG  1 
ATOM   1504 N ND1 . HIS   A 1 230 ? -47.751 -19.264 -4.279  1.00 32.95  ? 603 HIS   A ND1 1 
ATOM   1505 C CD2 . HIS   A 1 230 ? -47.068 -19.999 -6.216  1.00 34.13  ? 603 HIS   A CD2 1 
ATOM   1506 C CE1 . HIS   A 1 230 ? -47.028 -20.356 -4.065  1.00 35.91  ? 603 HIS   A CE1 1 
ATOM   1507 N NE2 . HIS   A 1 230 ? -46.626 -20.832 -5.230  1.00 34.07  ? 603 HIS   A NE2 1 
ATOM   1508 N N   A TYR   A 1 231 ? -51.150 -16.214 -6.019  0.50 44.61  ? 604 TYR   A N   1 
ATOM   1509 N N   B TYR   A 1 231 ? -51.165 -16.218 -6.019  0.50 43.26  ? 604 TYR   A N   1 
ATOM   1510 C CA  A TYR   A 1 231 ? -51.590 -14.849 -6.240  0.50 47.76  ? 604 TYR   A CA  1 
ATOM   1511 C CA  B TYR   A 1 231 ? -51.582 -14.842 -6.230  0.50 45.28  ? 604 TYR   A CA  1 
ATOM   1512 C C   A TYR   A 1 231 ? -50.348 -13.964 -6.183  0.50 45.56  ? 604 TYR   A C   1 
ATOM   1513 C C   B TYR   A 1 231 ? -50.322 -13.988 -6.188  0.50 44.24  ? 604 TYR   A C   1 
ATOM   1514 O O   A TYR   A 1 231 ? -49.767 -13.791 -5.119  0.50 45.80  ? 604 TYR   A O   1 
ATOM   1515 O O   B TYR   A 1 231 ? -49.699 -13.864 -5.140  0.50 44.62  ? 604 TYR   A O   1 
ATOM   1516 C CB  A TYR   A 1 231 ? -52.662 -14.490 -5.202  0.50 50.84  ? 604 TYR   A CB  1 
ATOM   1517 C CB  B TYR   A 1 231 ? -52.608 -14.380 -5.186  0.50 46.13  ? 604 TYR   A CB  1 
ATOM   1518 C CG  A TYR   A 1 231 ? -53.909 -15.367 -5.232  0.50 57.40  ? 604 TYR   A CG  1 
ATOM   1519 C CG  B TYR   A 1 231 ? -53.125 -12.958 -5.385  0.50 50.30  ? 604 TYR   A CG  1 
ATOM   1520 C CD1 A TYR   A 1 231 ? -54.977 -15.078 -6.076  0.50 63.21  ? 604 TYR   A CD1 1 
ATOM   1521 C CD1 B TYR   A 1 231 ? -54.065 -12.666 -6.369  0.50 51.93  ? 604 TYR   A CD1 1 
ATOM   1522 C CD2 A TYR   A 1 231 ? -54.027 -16.478 -4.404  0.50 61.21  ? 604 TYR   A CD2 1 
ATOM   1523 C CD2 B TYR   A 1 231 ? -52.694 -11.912 -4.575  0.50 50.07  ? 604 TYR   A CD2 1 
ATOM   1524 C CE1 A TYR   A 1 231 ? -56.115 -15.870 -6.103  0.50 63.57  ? 604 TYR   A CE1 1 
ATOM   1525 C CE1 B TYR   A 1 231 ? -54.548 -11.380 -6.549  0.50 53.13  ? 604 TYR   A CE1 1 
ATOM   1526 C CE2 A TYR   A 1 231 ? -55.158 -17.278 -4.422  0.50 61.61  ? 604 TYR   A CE2 1 
ATOM   1527 C CE2 B TYR   A 1 231 ? -53.163 -10.622 -4.749  0.50 50.50  ? 604 TYR   A CE2 1 
ATOM   1528 C CZ  A TYR   A 1 231 ? -56.204 -16.972 -5.272  0.50 62.24  ? 604 TYR   A CZ  1 
ATOM   1529 C CZ  B TYR   A 1 231 ? -54.092 -10.357 -5.738  0.50 53.38  ? 604 TYR   A CZ  1 
ATOM   1530 O OH  A TYR   A 1 231 ? -57.314 -17.762 -5.281  0.50 65.35  ? 604 TYR   A OH  1 
ATOM   1531 O OH  B TYR   A 1 231 ? -54.554 -9.088  -5.917  0.50 62.76  ? 604 TYR   A OH  1 
ATOM   1532 N N   . GLY   A 1 232 ? -49.948 -13.423 -7.339  1.00 45.35  ? 605 GLY   A N   1 
ATOM   1533 C CA  . GLY   A 1 232 ? -48.664 -12.760 -7.486  1.00 41.98  ? 605 GLY   A CA  1 
ATOM   1534 C C   . GLY   A 1 232 ? -47.637 -13.753 -8.030  1.00 38.38  ? 605 GLY   A C   1 
ATOM   1535 O O   . GLY   A 1 232 ? -48.015 -14.792 -8.560  1.00 38.73  ? 605 GLY   A O   1 
ATOM   1536 N N   . GLU   A 1 233 ? -46.354 -13.434 -7.859  1.00 35.01  ? 606 GLU   A N   1 
ATOM   1537 C CA  . GLU   A 1 233 ? -45.269 -14.127 -8.531  1.00 37.09  ? 606 GLU   A CA  1 
ATOM   1538 C C   . GLU   A 1 233 ? -44.967 -15.471 -7.874  1.00 36.86  ? 606 GLU   A C   1 
ATOM   1539 O O   . GLU   A 1 233 ? -45.040 -15.638 -6.659  1.00 32.31  ? 606 GLU   A O   1 
ATOM   1540 C CB  . GLU   A 1 233 ? -43.988 -13.293 -8.525  1.00 38.46  ? 606 GLU   A CB  1 
ATOM   1541 C CG  . GLU   A 1 233 ? -44.133 -11.906 -9.149  1.00 40.62  ? 606 GLU   A CG  1 
ATOM   1542 C CD  . GLU   A 1 233 ? -42.793 -11.255 -9.457  1.00 43.69  ? 606 GLU   A CD  1 
ATOM   1543 O OE1 . GLU   A 1 233 ? -42.024 -11.856 -10.219 1.00 42.48  ? 606 GLU   A OE1 1 
ATOM   1544 O OE2 . GLU   A 1 233 ? -42.494 -10.177 -8.916  1.00 51.75  ? 606 GLU   A OE2 1 
ATOM   1545 N N   . VAL   A 1 234 ? -44.583 -16.434 -8.713  1.00 34.22  ? 607 VAL   A N   1 
ATOM   1546 C CA  . VAL   A 1 234 ? -43.897 -17.623 -8.239  1.00 31.06  ? 607 VAL   A CA  1 
ATOM   1547 C C   . VAL   A 1 234 ? -42.403 -17.328 -8.118  1.00 31.52  ? 607 VAL   A C   1 
ATOM   1548 O O   . VAL   A 1 234 ? -41.787 -16.845 -9.072  1.00 30.85  ? 607 VAL   A O   1 
ATOM   1549 C CB  . VAL   A 1 234 ? -44.129 -18.794 -9.212  1.00 31.06  ? 607 VAL   A CB  1 
ATOM   1550 C CG1 . VAL   A 1 234 ? -43.733 -20.115 -8.584  1.00 30.55  ? 607 VAL   A CG1 1 
ATOM   1551 C CG2 . VAL   A 1 234 ? -45.560 -18.842 -9.731  1.00 30.08  ? 607 VAL   A CG2 1 
ATOM   1552 N N   . TYR   A 1 235 ? -41.804 -17.696 -6.975  1.00 29.69  ? 608 TYR   A N   1 
ATOM   1553 C CA  . TYR   A 1 235 ? -40.401 -17.413 -6.721  1.00 31.82  ? 608 TYR   A CA  1 
ATOM   1554 C C   . TYR   A 1 235 ? -39.483 -18.628 -6.862  1.00 33.32  ? 608 TYR   A C   1 
ATOM   1555 O O   . TYR   A 1 235 ? -38.331 -18.470 -7.266  1.00 34.33  ? 608 TYR   A O   1 
ATOM   1556 C CB  . TYR   A 1 235 ? -40.270 -16.900 -5.294  1.00 34.17  ? 608 TYR   A CB  1 
ATOM   1557 C CG  . TYR   A 1 235 ? -40.926 -15.555 -5.042  1.00 38.56  ? 608 TYR   A CG  1 
ATOM   1558 C CD1 . TYR   A 1 235 ? -40.930 -14.545 -6.002  1.00 42.62  ? 608 TYR   A CD1 1 
ATOM   1559 C CD2 . TYR   A 1 235 ? -41.515 -15.293 -3.817  1.00 40.31  ? 608 TYR   A CD2 1 
ATOM   1560 C CE1 . TYR   A 1 235 ? -41.507 -13.312 -5.745  1.00 42.14  ? 608 TYR   A CE1 1 
ATOM   1561 C CE2 . TYR   A 1 235 ? -42.086 -14.067 -3.548  1.00 43.12  ? 608 TYR   A CE2 1 
ATOM   1562 C CZ  . TYR   A 1 235 ? -42.082 -13.076 -4.511  1.00 42.23  ? 608 TYR   A CZ  1 
ATOM   1563 O OH  . TYR   A 1 235 ? -42.654 -11.886 -4.193  1.00 49.29  ? 608 TYR   A OH  1 
ATOM   1564 N N   . SER   A 1 236 ? -39.940 -19.813 -6.436  1.00 30.37  ? 609 SER   A N   1 
ATOM   1565 C CA  . SER   A 1 236 ? -39.134 -21.020 -6.534  1.00 32.30  ? 609 SER   A CA  1 
ATOM   1566 C C   . SER   A 1 236 ? -40.031 -22.224 -6.796  1.00 30.92  ? 609 SER   A C   1 
ATOM   1567 O O   . SER   A 1 236 ? -41.187 -22.262 -6.378  1.00 31.23  ? 609 SER   A O   1 
ATOM   1568 C CB  . SER   A 1 236 ? -38.272 -21.241 -5.314  1.00 35.41  ? 609 SER   A CB  1 
ATOM   1569 O OG  . SER   A 1 236 ? -37.405 -20.146 -5.041  1.00 35.54  ? 609 SER   A OG  1 
ATOM   1570 N N   . VAL   A 1 237 ? -39.489 -23.165 -7.565  1.00 33.06  ? 610 VAL   A N   1 
ATOM   1571 C CA  . VAL   A 1 237 ? -40.152 -24.408 -7.920  1.00 32.94  ? 610 VAL   A CA  1 
ATOM   1572 C C   . VAL   A 1 237 ? -39.131 -25.544 -7.833  1.00 36.75  ? 610 VAL   A C   1 
ATOM   1573 O O   . VAL   A 1 237 ? -37.935 -25.328 -8.030  1.00 41.20  ? 610 VAL   A O   1 
ATOM   1574 C CB  . VAL   A 1 237 ? -40.779 -24.362 -9.314  1.00 35.45  ? 610 VAL   A CB  1 
ATOM   1575 C CG1 . VAL   A 1 237 ? -41.932 -23.370 -9.381  1.00 34.89  ? 610 VAL   A CG1 1 
ATOM   1576 C CG2 . VAL   A 1 237 ? -39.715 -24.088 -10.387 1.00 39.65  ? 610 VAL   A CG2 1 
ATOM   1577 N N   . GLU   A 1 238 ? -39.625 -26.755 -7.552  1.00 33.91  ? 611 GLU   A N   1 
ATOM   1578 C CA  . GLU   A 1 238 ? -38.779 -27.917 -7.362  1.00 37.15  ? 611 GLU   A CA  1 
ATOM   1579 C C   . GLU   A 1 238 ? -39.632 -29.173 -7.482  1.00 36.46  ? 611 GLU   A C   1 
ATOM   1580 O O   . GLU   A 1 238 ? -40.798 -29.159 -7.097  1.00 32.40  ? 611 GLU   A O   1 
ATOM   1581 C CB  . GLU   A 1 238 ? -38.161 -27.897 -5.966  1.00 45.17  ? 611 GLU   A CB  1 
ATOM   1582 C CG  . GLU   A 1 238 ? -37.065 -28.938 -5.741  1.00 56.12  ? 611 GLU   A CG  1 
ATOM   1583 C CD  . GLU   A 1 238 ? -35.646 -28.539 -6.130  1.00 64.95  ? 611 GLU   A CD  1 
ATOM   1584 O OE1 . GLU   A 1 238 ? -35.463 -27.587 -6.927  1.00 71.93  ? 611 GLU   A OE1 1 
ATOM   1585 O OE2 . GLU   A 1 238 ? -34.713 -29.179 -5.587  1.00 71.05  ? 611 GLU   A OE2 1 
ATOM   1586 N N   . PHE   A 1 239 ? -39.034 -30.237 -8.033  1.00 35.48  ? 612 PHE   A N   1 
ATOM   1587 C CA  . PHE   A 1 239 ? -39.639 -31.562 -8.044  1.00 35.11  ? 612 PHE   A CA  1 
ATOM   1588 C C   . PHE   A 1 239 ? -39.415 -32.199 -6.675  1.00 35.34  ? 612 PHE   A C   1 
ATOM   1589 O O   . PHE   A 1 239 ? -38.347 -32.038 -6.102  1.00 36.42  ? 612 PHE   A O   1 
ATOM   1590 C CB  . PHE   A 1 239 ? -39.016 -32.429 -9.147  1.00 32.91  ? 612 PHE   A CB  1 
ATOM   1591 C CG  . PHE   A 1 239 ? -39.448 -32.044 -10.556 1.00 34.19  ? 612 PHE   A CG  1 
ATOM   1592 C CD1 . PHE   A 1 239 ? -40.592 -32.588 -11.126 1.00 35.49  ? 612 PHE   A CD1 1 
ATOM   1593 C CD2 . PHE   A 1 239 ? -38.719 -31.124 -11.301 1.00 31.42  ? 612 PHE   A CD2 1 
ATOM   1594 C CE1 . PHE   A 1 239 ? -41.007 -32.196 -12.389 1.00 35.69  ? 612 PHE   A CE1 1 
ATOM   1595 C CE2 . PHE   A 1 239 ? -39.149 -30.733 -12.551 1.00 33.16  ? 612 PHE   A CE2 1 
ATOM   1596 C CZ  . PHE   A 1 239 ? -40.272 -31.284 -13.105 1.00 34.78  ? 612 PHE   A CZ  1 
ATOM   1597 N N   . SER   A 1 240 ? -40.403 -32.943 -6.164  1.00 35.41  ? 613 SER   A N   1 
ATOM   1598 C CA  . SER   A 1 240 ? -40.177 -33.814 -5.014  1.00 38.16  ? 613 SER   A CA  1 
ATOM   1599 C C   . SER   A 1 240 ? -39.195 -34.919 -5.397  1.00 37.29  ? 613 SER   A C   1 
ATOM   1600 O O   . SER   A 1 240 ? -39.010 -35.217 -6.574  1.00 38.79  ? 613 SER   A O   1 
ATOM   1601 C CB  . SER   A 1 240 ? -41.471 -34.412 -4.492  1.00 36.26  ? 613 SER   A CB  1 
ATOM   1602 O OG  . SER   A 1 240 ? -42.065 -35.241 -5.480  1.00 34.09  ? 613 SER   A OG  1 
ATOM   1603 N N   . TYR   A 1 241 ? -38.581 -35.538 -4.390  1.00 40.69  ? 614 TYR   A N   1 
ATOM   1604 C CA  . TYR   A 1 241 ? -37.639 -36.621 -4.616  1.00 40.31  ? 614 TYR   A CA  1 
ATOM   1605 C C   . TYR   A 1 241 ? -38.280 -37.677 -5.521  1.00 39.05  ? 614 TYR   A C   1 
ATOM   1606 O O   . TYR   A 1 241 ? -37.639 -38.141 -6.451  1.00 41.14  ? 614 TYR   A O   1 
ATOM   1607 C CB  . TYR   A 1 241 ? -37.141 -37.150 -3.263  1.00 44.52  ? 614 TYR   A CB  1 
ATOM   1608 C CG  . TYR   A 1 241 ? -36.124 -38.278 -3.382  1.00 52.91  ? 614 TYR   A CG  1 
ATOM   1609 C CD1 . TYR   A 1 241 ? -34.795 -38.020 -3.702  1.00 58.55  ? 614 TYR   A CD1 1 
ATOM   1610 C CD2 . TYR   A 1 241 ? -36.502 -39.606 -3.205  1.00 62.72  ? 614 TYR   A CD2 1 
ATOM   1611 C CE1 . TYR   A 1 241 ? -33.873 -39.044 -3.834  1.00 62.14  ? 614 TYR   A CE1 1 
ATOM   1612 C CE2 . TYR   A 1 241 ? -35.590 -40.642 -3.334  1.00 63.29  ? 614 TYR   A CE2 1 
ATOM   1613 C CZ  . TYR   A 1 241 ? -34.272 -40.356 -3.645  1.00 64.94  ? 614 TYR   A CZ  1 
ATOM   1614 O OH  . TYR   A 1 241 ? -33.378 -41.369 -3.783  1.00 69.70  ? 614 TYR   A OH  1 
ATOM   1615 N N   . ASP   A 1 242 ? -39.553 -38.021 -5.289  1.00 42.02  ? 615 ASP   A N   1 
ATOM   1616 C CA  . ASP   A 1 242 ? -40.207 -39.122 -5.989  1.00 41.11  ? 615 ASP   A CA  1 
ATOM   1617 C C   . ASP   A 1 242 ? -40.841 -38.646 -7.287  1.00 39.53  ? 615 ASP   A C   1 
ATOM   1618 O O   . ASP   A 1 242 ? -41.304 -39.461 -8.072  1.00 38.74  ? 615 ASP   A O   1 
ATOM   1619 C CB  . ASP   A 1 242 ? -41.224 -39.830 -5.102  1.00 44.55  ? 615 ASP   A CB  1 
ATOM   1620 C CG  . ASP   A 1 242 ? -42.519 -39.100 -4.742  1.00 49.05  ? 615 ASP   A CG  1 
ATOM   1621 O OD1 . ASP   A 1 242 ? -42.732 -37.940 -5.186  1.00 42.45  ? 615 ASP   A OD1 1 
ATOM   1622 O OD2 . ASP   A 1 242 ? -43.334 -39.711 -4.014  1.00 51.35  ? 615 ASP   A OD2 1 
ATOM   1623 N N   . GLU   A 1 243 ? -40.936 -37.321 -7.457  1.00 40.57  ? 616 GLU   A N   1 
ATOM   1624 C CA  . GLU   A 1 243 ? -41.420 -36.687 -8.674  1.00 40.92  ? 616 GLU   A CA  1 
ATOM   1625 C C   . GLU   A 1 243 ? -42.912 -36.934 -8.877  1.00 42.70  ? 616 GLU   A C   1 
ATOM   1626 O O   . GLU   A 1 243 ? -43.403 -36.845 -10.002 1.00 44.44  ? 616 GLU   A O   1 
ATOM   1627 C CB  . GLU   A 1 243 ? -40.578 -37.071 -9.894  1.00 40.80  ? 616 GLU   A CB  1 
ATOM   1628 C CG  . GLU   A 1 243 ? -39.092 -36.847 -9.627  1.00 42.92  ? 616 GLU   A CG  1 
ATOM   1629 C CD  . GLU   A 1 243 ? -38.202 -36.793 -10.850 1.00 43.51  ? 616 GLU   A CD  1 
ATOM   1630 O OE1 . GLU   A 1 243 ? -38.678 -37.191 -11.926 1.00 43.22  ? 616 GLU   A OE1 1 
ATOM   1631 O OE2 . GLU   A 1 243 ? -37.059 -36.311 -10.717 1.00 41.53  ? 616 GLU   A OE2 1 
ATOM   1632 N N   . ASN   A 1 244 ? -43.660 -37.156 -7.794  1.00 39.13  ? 617 ASN   A N   1 
ATOM   1633 C CA  . ASN   A 1 244 ? -45.108 -37.196 -7.939  1.00 41.09  ? 617 ASN   A CA  1 
ATOM   1634 C C   . ASN   A 1 244 ? -45.698 -35.811 -7.710  1.00 38.72  ? 617 ASN   A C   1 
ATOM   1635 O O   . ASN   A 1 244 ? -46.867 -35.596 -8.014  1.00 38.73  ? 617 ASN   A O   1 
ATOM   1636 C CB  . ASN   A 1 244 ? -45.749 -38.242 -7.034  1.00 42.95  ? 617 ASN   A CB  1 
ATOM   1637 C CG  . ASN   A 1 244 ? -45.449 -39.633 -7.538  1.00 44.56  ? 617 ASN   A CG  1 
ATOM   1638 O OD1 . ASN   A 1 244 ? -45.728 -39.939 -8.703  1.00 41.95  ? 617 ASN   A OD1 1 
ATOM   1639 N ND2 . ASN   A 1 244 ? -44.825 -40.448 -6.701  1.00 43.06  ? 617 ASN   A ND2 1 
ATOM   1640 N N   . THR   A 1 245 ? -44.899 -34.890 -7.157  1.00 36.96  ? 618 THR   A N   1 
ATOM   1641 C CA  . THR   A 1 245 ? -45.381 -33.543 -6.887  1.00 38.62  ? 618 THR   A CA  1 
ATOM   1642 C C   . THR   A 1 245 ? -44.301 -32.534 -7.261  1.00 36.83  ? 618 THR   A C   1 
ATOM   1643 O O   . THR   A 1 245 ? -43.137 -32.894 -7.385  1.00 32.92  ? 618 THR   A O   1 
ATOM   1644 C CB  . THR   A 1 245 ? -45.773 -33.391 -5.413  1.00 39.62  ? 618 THR   A CB  1 
ATOM   1645 O OG1 . THR   A 1 245 ? -44.656 -33.631 -4.563  1.00 37.86  ? 618 THR   A OG1 1 
ATOM   1646 C CG2 . THR   A 1 245 ? -46.891 -34.327 -5.002  1.00 42.88  ? 618 THR   A CG2 1 
ATOM   1647 N N   . VAL   A 1 246 ? -44.711 -31.269 -7.408  1.00 36.04  ? 619 VAL   A N   1 
ATOM   1648 C CA  . VAL   A 1 246 ? -43.773 -30.164 -7.397  1.00 36.69  ? 619 VAL   A CA  1 
ATOM   1649 C C   . VAL   A 1 246 ? -44.124 -29.216 -6.252  1.00 35.71  ? 619 VAL   A C   1 
ATOM   1650 O O   . VAL   A 1 246 ? -45.279 -29.059 -5.874  1.00 37.45  ? 619 VAL   A O   1 
ATOM   1651 C CB  . VAL   A 1 246 ? -43.705 -29.449 -8.757  1.00 37.14  ? 619 VAL   A CB  1 
ATOM   1652 C CG1 . VAL   A 1 246 ? -43.355 -30.430 -9.874  1.00 38.32  ? 619 VAL   A CG1 1 
ATOM   1653 C CG2 . VAL   A 1 246 ? -44.979 -28.718 -9.091  1.00 38.93  ? 619 VAL   A CG2 1 
ATOM   1654 N N   . TYR   A 1 247 ? -43.088 -28.636 -5.659  1.00 34.94  ? 620 TYR   A N   1 
ATOM   1655 C CA  . TYR   A 1 247 ? -43.252 -27.649 -4.611  1.00 36.62  ? 620 TYR   A CA  1 
ATOM   1656 C C   . TYR   A 1 247 ? -43.044 -26.262 -5.203  1.00 35.10  ? 620 TYR   A C   1 
ATOM   1657 O O   . TYR   A 1 247 ? -42.176 -26.065 -6.057  1.00 31.99  ? 620 TYR   A O   1 
ATOM   1658 C CB  . TYR   A 1 247 ? -42.231 -27.901 -3.500  1.00 40.89  ? 620 TYR   A CB  1 
ATOM   1659 C CG  . TYR   A 1 247 ? -42.366 -29.251 -2.812  1.00 41.81  ? 620 TYR   A CG  1 
ATOM   1660 C CD1 . TYR   A 1 247 ? -43.409 -29.505 -1.935  1.00 47.50  ? 620 TYR   A CD1 1 
ATOM   1661 C CD2 . TYR   A 1 247 ? -41.417 -30.243 -2.998  1.00 45.87  ? 620 TYR   A CD2 1 
ATOM   1662 C CE1 . TYR   A 1 247 ? -43.511 -30.718 -1.272  1.00 51.20  ? 620 TYR   A CE1 1 
ATOM   1663 C CE2 . TYR   A 1 247 ? -41.517 -31.467 -2.359  1.00 49.94  ? 620 TYR   A CE2 1 
ATOM   1664 C CZ  . TYR   A 1 247 ? -42.568 -31.701 -1.494  1.00 47.50  ? 620 TYR   A CZ  1 
ATOM   1665 O OH  . TYR   A 1 247 ? -42.657 -32.908 -0.882  1.00 66.55  ? 620 TYR   A OH  1 
ATOM   1666 N N   . SER   A 1 248 ? -43.824 -25.300 -4.716  1.00 34.36  ? 621 SER   A N   1 
ATOM   1667 C CA  . SER   A 1 248 ? -43.647 -23.920 -5.122  1.00 34.64  ? 621 SER   A CA  1 
ATOM   1668 C C   . SER   A 1 248 ? -43.806 -22.998 -3.920  1.00 35.78  ? 621 SER   A C   1 
ATOM   1669 O O   . SER   A 1 248 ? -44.435 -23.355 -2.916  1.00 33.68  ? 621 SER   A O   1 
ATOM   1670 C CB  . SER   A 1 248 ? -44.600 -23.546 -6.208  1.00 33.14  ? 621 SER   A CB  1 
ATOM   1671 O OG  . SER   A 1 248 ? -45.912 -23.416 -5.694  1.00 35.78  ? 621 SER   A OG  1 
ATOM   1672 N N   . ILE   A 1 249 ? -43.197 -21.817 -4.056  1.00 33.34  ? 622 ILE   A N   1 
ATOM   1673 C CA  . ILE   A 1 249 ? -43.285 -20.754 -3.079  1.00 34.93  ? 622 ILE   A CA  1 
ATOM   1674 C C   . ILE   A 1 249 ? -43.396 -19.449 -3.855  1.00 38.59  ? 622 ILE   A C   1 
ATOM   1675 O O   . ILE   A 1 249 ? -42.750 -19.294 -4.896  1.00 33.92  ? 622 ILE   A O   1 
ATOM   1676 C CB  . ILE   A 1 249 ? -42.091 -20.803 -2.122  1.00 41.38  ? 622 ILE   A CB  1 
ATOM   1677 C CG1 . ILE   A 1 249 ? -42.224 -19.780 -1.007  1.00 41.54  ? 622 ILE   A CG1 1 
ATOM   1678 C CG2 . ILE   A 1 249 ? -40.772 -20.660 -2.883  1.00 42.68  ? 622 ILE   A CG2 1 
ATOM   1679 C CD1 . ILE   A 1 249 ? -41.211 -19.994 0.105   1.00 44.60  ? 622 ILE   A CD1 1 
ATOM   1680 N N   . GLY   A 1 250 ? -44.293 -18.570 -3.381  1.00 35.73  ? 623 GLY   A N   1 
ATOM   1681 C CA  . GLY   A 1 250 ? -44.711 -17.402 -4.138  1.00 35.66  ? 623 GLY   A CA  1 
ATOM   1682 C C   . GLY   A 1 250 ? -44.998 -16.180 -3.263  1.00 35.59  ? 623 GLY   A C   1 
ATOM   1683 O O   . GLY   A 1 250 ? -44.909 -16.211 -2.033  1.00 32.60  ? 623 GLY   A O   1 
ATOM   1684 N N   . GLU   A 1 251 ? -45.345 -15.094 -3.956  1.00 36.76  ? 624 GLU   A N   1 
ATOM   1685 C CA  . GLU   A 1 251 ? -45.481 -13.767 -3.378  1.00 41.24  ? 624 GLU   A CA  1 
ATOM   1686 C C   . GLU   A 1 251 ? -46.591 -13.713 -2.316  1.00 39.76  ? 624 GLU   A C   1 
ATOM   1687 O O   . GLU   A 1 251 ? -46.560 -12.851 -1.446  1.00 37.89  ? 624 GLU   A O   1 
ATOM   1688 C CB  . GLU   A 1 251 ? -45.733 -12.810 -4.545  1.00 40.53  ? 624 GLU   A CB  1 
ATOM   1689 C CG  . GLU   A 1 251 ? -45.878 -11.352 -4.117  1.00 42.77  ? 624 GLU   A CG  1 
ATOM   1690 C CD  . GLU   A 1 251 ? -45.920 -10.363 -5.261  1.00 44.87  ? 624 GLU   A CD  1 
ATOM   1691 O OE1 . GLU   A 1 251 ? -46.104 -10.803 -6.423  1.00 41.85  ? 624 GLU   A OE1 1 
ATOM   1692 O OE2 . GLU   A 1 251 ? -45.746 -9.152  -4.978  1.00 45.91  ? 624 GLU   A OE2 1 
ATOM   1693 N N   . ASP   A 1 252 ? -47.555 -14.638 -2.379  1.00 37.57  ? 625 ASP   A N   1 
ATOM   1694 C CA  . ASP   A 1 252 ? -48.645 -14.680 -1.416  1.00 39.88  ? 625 ASP   A CA  1 
ATOM   1695 C C   . ASP   A 1 252 ? -48.189 -15.338 -0.120  1.00 39.15  ? 625 ASP   A C   1 
ATOM   1696 O O   . ASP   A 1 252 ? -48.981 -15.528 0.790   1.00 43.85  ? 625 ASP   A O   1 
ATOM   1697 C CB  . ASP   A 1 252 ? -49.862 -15.382 -1.992  1.00 37.29  ? 625 ASP   A CB  1 
ATOM   1698 C CG  . ASP   A 1 252 ? -49.588 -16.727 -2.649  1.00 39.02  ? 625 ASP   A CG  1 
ATOM   1699 O OD1 . ASP   A 1 252 ? -48.480 -17.292 -2.436  1.00 37.89  ? 625 ASP   A OD1 1 
ATOM   1700 O OD2 . ASP   A 1 252 ? -50.458 -17.159 -3.420  1.00 36.95  ? 625 ASP   A OD2 1 
ATOM   1701 N N   . GLY   A 1 253 ? -46.914 -15.706 -0.038  1.00 37.63  ? 626 GLY   A N   1 
ATOM   1702 C CA  . GLY   A 1 253 ? -46.391 -16.276 1.189   1.00 38.32  ? 626 GLY   A CA  1 
ATOM   1703 C C   . GLY   A 1 253 ? -46.742 -17.756 1.348   1.00 38.82  ? 626 GLY   A C   1 
ATOM   1704 O O   . GLY   A 1 253 ? -46.362 -18.356 2.338   1.00 42.13  ? 626 GLY   A O   1 
ATOM   1705 N N   . LYS   A 1 254 ? -47.404 -18.363 0.355   1.00 39.80  ? 627 LYS   A N   1 
ATOM   1706 C CA  . LYS   A 1 254 ? -47.761 -19.770 0.447   1.00 41.93  ? 627 LYS   A CA  1 
ATOM   1707 C C   . LYS   A 1 254 ? -46.627 -20.663 -0.060  1.00 40.72  ? 627 LYS   A C   1 
ATOM   1708 O O   . LYS   A 1 254 ? -45.936 -20.344 -1.027  1.00 38.18  ? 627 LYS   A O   1 
ATOM   1709 C CB  . LYS   A 1 254 ? -49.056 -20.046 -0.325  1.00 46.34  ? 627 LYS   A CB  1 
ATOM   1710 C CG  . LYS   A 1 254 ? -50.214 -19.082 -0.064  1.00 52.05  ? 627 LYS   A CG  1 
ATOM   1711 C CD  . LYS   A 1 254 ? -51.242 -19.537 0.966   1.00 59.86  ? 627 LYS   A CD  1 
ATOM   1712 C CE  . LYS   A 1 254 ? -52.492 -18.690 1.003   1.00 61.16  ? 627 LYS   A CE  1 
ATOM   1713 N N   . PHE   A 1 255 ? -46.447 -21.793 0.628   1.00 39.07  ? 628 PHE   A N   1 
ATOM   1714 C CA  . PHE   A 1 255 ? -45.695 -22.932 0.144   1.00 34.91  ? 628 PHE   A CA  1 
ATOM   1715 C C   . PHE   A 1 255 ? -46.689 -24.034 -0.210  1.00 37.52  ? 628 PHE   A C   1 
ATOM   1716 O O   . PHE   A 1 255 ? -47.448 -24.501 0.640   1.00 38.95  ? 628 PHE   A O   1 
ATOM   1717 C CB  . PHE   A 1 255 ? -44.696 -23.370 1.210   1.00 36.64  ? 628 PHE   A CB  1 
ATOM   1718 C CG  . PHE   A 1 255 ? -44.089 -24.747 0.995   1.00 37.61  ? 628 PHE   A CG  1 
ATOM   1719 C CD1 . PHE   A 1 255 ? -43.043 -24.935 0.102   1.00 41.78  ? 628 PHE   A CD1 1 
ATOM   1720 C CD2 . PHE   A 1 255 ? -44.556 -25.842 1.706   1.00 41.31  ? 628 PHE   A CD2 1 
ATOM   1721 C CE1 . PHE   A 1 255 ? -42.490 -26.193 -0.088  1.00 42.06  ? 628 PHE   A CE1 1 
ATOM   1722 C CE2 . PHE   A 1 255 ? -44.002 -27.096 1.517   1.00 44.55  ? 628 PHE   A CE2 1 
ATOM   1723 C CZ  . PHE   A 1 255 ? -42.977 -27.274 0.614   1.00 43.82  ? 628 PHE   A CZ  1 
ATOM   1724 N N   . ILE   A 1 256 ? -46.686 -24.454 -1.476  1.00 35.73  ? 629 ILE   A N   1 
ATOM   1725 C CA  . ILE   A 1 256 ? -47.687 -25.391 -1.951  1.00 35.81  ? 629 ILE   A CA  1 
ATOM   1726 C C   . ILE   A 1 256 ? -47.010 -26.589 -2.599  1.00 37.54  ? 629 ILE   A C   1 
ATOM   1727 O O   . ILE   A 1 256 ? -45.939 -26.492 -3.193  1.00 37.59  ? 629 ILE   A O   1 
ATOM   1728 C CB  . ILE   A 1 256 ? -48.647 -24.686 -2.909  1.00 36.85  ? 629 ILE   A CB  1 
ATOM   1729 C CG1 . ILE   A 1 256 ? -49.173 -23.413 -2.262  1.00 38.80  ? 629 ILE   A CG1 1 
ATOM   1730 C CG2 . ILE   A 1 256 ? -49.754 -25.632 -3.371  1.00 39.39  ? 629 ILE   A CG2 1 
ATOM   1731 C CD1 . ILE   A 1 256 ? -50.217 -22.671 -3.063  1.00 39.72  ? 629 ILE   A CD1 1 
ATOM   1732 N N   . GLN   A 1 257 ? -47.667 -27.730 -2.452  1.00 36.89  ? 630 GLN   A N   1 
ATOM   1733 C CA  . GLN   A 1 257 ? -47.235 -28.949 -3.092  1.00 37.77  ? 630 GLN   A CA  1 
ATOM   1734 C C   . GLN   A 1 257 ? -48.337 -29.397 -4.032  1.00 39.62  ? 630 GLN   A C   1 
ATOM   1735 O O   . GLN   A 1 257 ? -49.470 -29.554 -3.591  1.00 37.78  ? 630 GLN   A O   1 
ATOM   1736 C CB  . GLN   A 1 257 ? -47.018 -30.009 -2.030  1.00 38.23  ? 630 GLN   A CB  1 
ATOM   1737 C CG  . GLN   A 1 257 ? -46.606 -31.364 -2.585  1.00 40.69  ? 630 GLN   A CG  1 
ATOM   1738 C CD  . GLN   A 1 257 ? -46.602 -32.395 -1.486  1.00 38.58  ? 630 GLN   A CD  1 
ATOM   1739 O OE1 . GLN   A 1 257 ? -47.247 -32.194 -0.454  1.00 47.41  ? 630 GLN   A OE1 1 
ATOM   1740 N NE2 . GLN   A 1 257 ? -45.852 -33.465 -1.673  1.00 36.23  ? 630 GLN   A NE2 1 
ATOM   1741 N N   . TRP   A 1 258 ? -47.973 -29.602 -5.302  1.00 36.42  ? 631 TRP   A N   1 
ATOM   1742 C CA  . TRP   A 1 258 ? -48.940 -29.853 -6.346  1.00 36.76  ? 631 TRP   A CA  1 
ATOM   1743 C C   . TRP   A 1 258 ? -48.780 -31.271 -6.872  1.00 40.13  ? 631 TRP   A C   1 
ATOM   1744 O O   . TRP   A 1 258 ? -47.678 -31.822 -6.889  1.00 39.14  ? 631 TRP   A O   1 
ATOM   1745 C CB  . TRP   A 1 258 ? -48.776 -28.855 -7.493  1.00 36.34  ? 631 TRP   A CB  1 
ATOM   1746 C CG  . TRP   A 1 258 ? -48.733 -27.421 -7.060  1.00 33.54  ? 631 TRP   A CG  1 
ATOM   1747 C CD1 . TRP   A 1 258 ? -47.640 -26.710 -6.654  1.00 34.78  ? 631 TRP   A CD1 1 
ATOM   1748 C CD2 . TRP   A 1 258 ? -49.837 -26.505 -7.046  1.00 35.64  ? 631 TRP   A CD2 1 
ATOM   1749 N NE1 . TRP   A 1 258 ? -47.986 -25.415 -6.390  1.00 32.35  ? 631 TRP   A NE1 1 
ATOM   1750 C CE2 . TRP   A 1 258 ? -49.326 -25.262 -6.614  1.00 33.70  ? 631 TRP   A CE2 1 
ATOM   1751 C CE3 . TRP   A 1 258 ? -51.194 -26.616 -7.354  1.00 36.36  ? 631 TRP   A CE3 1 
ATOM   1752 C CZ2 . TRP   A 1 258 ? -50.132 -24.139 -6.490  1.00 36.13  ? 631 TRP   A CZ2 1 
ATOM   1753 C CZ3 . TRP   A 1 258 ? -51.985 -25.499 -7.238  1.00 37.40  ? 631 TRP   A CZ3 1 
ATOM   1754 C CH2 . TRP   A 1 258 ? -51.460 -24.277 -6.819  1.00 36.78  ? 631 TRP   A CH2 1 
ATOM   1755 N N   . ASN   A 1 259 ? -49.916 -31.817 -7.309  1.00 38.01  ? 632 ASN   A N   1 
ATOM   1756 C CA  . ASN   A 1 259 ? -49.992 -33.128 -7.913  1.00 40.74  ? 632 ASN   A CA  1 
ATOM   1757 C C   . ASN   A 1 259 ? -49.509 -32.995 -9.351  1.00 37.33  ? 632 ASN   A C   1 
ATOM   1758 O O   . ASN   A 1 259 ? -50.123 -32.274 -10.133 1.00 39.53  ? 632 ASN   A O   1 
ATOM   1759 C CB  . ASN   A 1 259 ? -51.434 -33.620 -7.842  1.00 45.57  ? 632 ASN   A CB  1 
ATOM   1760 C CG  . ASN   A 1 259 ? -51.594 -35.066 -8.233  1.00 46.14  ? 632 ASN   A CG  1 
ATOM   1761 O OD1 . ASN   A 1 259 ? -50.903 -35.544 -9.133  1.00 47.74  ? 632 ASN   A OD1 1 
ATOM   1762 N ND2 . ASN   A 1 259 ? -52.476 -35.780 -7.550  1.00 51.03  ? 632 ASN   A ND2 1 
ATOM   1763 N N   . ILE   A 1 260 ? -48.426 -33.693 -9.699  1.00 39.25  ? 633 ILE   A N   1 
ATOM   1764 C CA  . ILE   A 1 260 ? -47.846 -33.542 -11.021 1.00 45.95  ? 633 ILE   A CA  1 
ATOM   1765 C C   . ILE   A 1 260 ? -48.691 -34.289 -12.063 1.00 49.44  ? 633 ILE   A C   1 
ATOM   1766 O O   . ILE   A 1 260 ? -48.546 -34.036 -13.258 1.00 47.24  ? 633 ILE   A O   1 
ATOM   1767 C CB  . ILE   A 1 260 ? -46.366 -33.980 -11.029 1.00 47.30  ? 633 ILE   A CB  1 
ATOM   1768 C CG1 . ILE   A 1 260 ? -45.599 -33.259 -12.129 1.00 49.94  ? 633 ILE   A CG1 1 
ATOM   1769 C CG2 . ILE   A 1 260 ? -46.207 -35.500 -11.123 1.00 48.17  ? 633 ILE   A CG2 1 
ATOM   1770 C CD1 . ILE   A 1 260 ? -44.206 -33.809 -12.370 1.00 56.20  ? 633 ILE   A CD1 1 
ATOM   1771 N N   . HIS   A 1 261 ? -49.586 -35.185 -11.608 1.00 48.85  ? 634 HIS   A N   1 
ATOM   1772 C CA  . HIS   A 1 261 ? -50.384 -36.028 -12.491 1.00 46.16  ? 634 HIS   A CA  1 
ATOM   1773 C C   . HIS   A 1 261 ? -51.717 -35.367 -12.837 1.00 46.41  ? 634 HIS   A C   1 
ATOM   1774 O O   . HIS   A 1 261 ? -52.366 -35.777 -13.790 1.00 48.54  ? 634 HIS   A O   1 
ATOM   1775 C CB  . HIS   A 1 261 ? -50.604 -37.408 -11.861 1.00 48.11  ? 634 HIS   A CB  1 
ATOM   1776 C CG  . HIS   A 1 261 ? -49.331 -38.076 -11.445 1.00 46.01  ? 634 HIS   A CG  1 
ATOM   1777 N ND1 . HIS   A 1 261 ? -48.347 -38.398 -12.356 1.00 48.14  ? 634 HIS   A ND1 1 
ATOM   1778 C CD2 . HIS   A 1 261 ? -48.854 -38.426 -10.240 1.00 45.61  ? 634 HIS   A CD2 1 
ATOM   1779 C CE1 . HIS   A 1 261 ? -47.327 -38.966 -11.716 1.00 48.33  ? 634 HIS   A CE1 1 
ATOM   1780 N NE2 . HIS   A 1 261 ? -47.611 -38.994 -10.426 1.00 49.56  ? 634 HIS   A NE2 1 
ATOM   1781 N N   . LYS   A 1 262 ? -52.108 -34.327 -12.086 1.00 47.02  ? 635 LYS   A N   1 
ATOM   1782 C CA  . LYS   A 1 262 ? -53.395 -33.677 -12.277 1.00 45.35  ? 635 LYS   A CA  1 
ATOM   1783 C C   . LYS   A 1 262 ? -53.246 -32.175 -12.072 1.00 45.24  ? 635 LYS   A C   1 
ATOM   1784 O O   . LYS   A 1 262 ? -52.912 -31.710 -10.981 1.00 42.45  ? 635 LYS   A O   1 
ATOM   1785 C CB  . LYS   A 1 262 ? -54.419 -34.251 -11.294 1.00 48.89  ? 635 LYS   A CB  1 
ATOM   1786 C CG  . LYS   A 1 262 ? -54.665 -35.741 -11.444 1.00 51.24  ? 635 LYS   A CG  1 
ATOM   1787 C CD  . LYS   A 1 262 ? -55.968 -36.167 -10.779 1.00 60.54  ? 635 LYS   A CD  1 
ATOM   1788 C CE  . LYS   A 1 262 ? -56.433 -37.537 -11.168 1.00 58.60  ? 635 LYS   A CE  1 
ATOM   1789 N NZ  . LYS   A 1 262 ? -55.612 -38.551 -10.510 1.00 56.52  ? 635 LYS   A NZ  1 
ATOM   1790 N N   . SER   A 1 263 ? -53.521 -31.419 -13.138 1.00 45.74  ? 636 SER   A N   1 
ATOM   1791 C CA  . SER   A 1 263 ? -53.036 -30.054 -13.238 1.00 48.00  ? 636 SER   A CA  1 
ATOM   1792 C C   . SER   A 1 263 ? -53.753 -29.161 -12.227 1.00 47.34  ? 636 SER   A C   1 
ATOM   1793 O O   . SER   A 1 263 ? -54.970 -29.026 -12.280 1.00 46.54  ? 636 SER   A O   1 
ATOM   1794 C CB  . SER   A 1 263 ? -53.187 -29.537 -14.643 1.00 47.46  ? 636 SER   A CB  1 
ATOM   1795 O OG  . SER   A 1 263 ? -52.657 -28.223 -14.751 1.00 52.35  ? 636 SER   A OG  1 
ATOM   1796 N N   . GLY   A 1 264 ? -52.987 -28.554 -11.311 1.00 48.11  ? 637 GLY   A N   1 
ATOM   1797 C CA  . GLY   A 1 264 ? -53.534 -27.575 -10.379 1.00 49.11  ? 637 GLY   A CA  1 
ATOM   1798 C C   . GLY   A 1 264 ? -54.160 -28.203 -9.132  1.00 46.39  ? 637 GLY   A C   1 
ATOM   1799 O O   . GLY   A 1 264 ? -54.711 -27.495 -8.298  1.00 46.36  ? 637 GLY   A O   1 
ATOM   1800 N N   . LEU   A 1 265 ? -54.042 -29.525 -8.979  1.00 47.94  ? 638 LEU   A N   1 
ATOM   1801 C CA  . LEU   A 1 265 ? -54.577 -30.194 -7.806  1.00 48.36  ? 638 LEU   A CA  1 
ATOM   1802 C C   . LEU   A 1 265 ? -53.553 -30.099 -6.676  1.00 41.88  ? 638 LEU   A C   1 
ATOM   1803 O O   . LEU   A 1 265 ? -52.432 -30.577 -6.816  1.00 40.70  ? 638 LEU   A O   1 
ATOM   1804 C CB  . LEU   A 1 265 ? -54.895 -31.643 -8.174  1.00 56.86  ? 638 LEU   A CB  1 
ATOM   1805 C CG  . LEU   A 1 265 ? -56.006 -32.327 -7.373  1.00 66.81  ? 638 LEU   A CG  1 
ATOM   1806 C CD1 . LEU   A 1 265 ? -56.022 -33.806 -7.727  1.00 67.84  ? 638 LEU   A CD1 1 
ATOM   1807 C CD2 . LEU   A 1 265 ? -55.888 -32.145 -5.862  1.00 70.75  ? 638 LEU   A CD2 1 
ATOM   1808 N N   . LYS   A 1 266 ? -53.951 -29.488 -5.554  1.00 38.50  ? 639 LYS   A N   1 
ATOM   1809 C CA  . LYS   A 1 266 ? -53.079 -29.340 -4.403  1.00 39.96  ? 639 LYS   A CA  1 
ATOM   1810 C C   . LYS   A 1 266 ? -53.013 -30.651 -3.628  1.00 40.55  ? 639 LYS   A C   1 
ATOM   1811 O O   . LYS   A 1 266 ? -53.987 -31.382 -3.555  1.00 44.09  ? 639 LYS   A O   1 
ATOM   1812 C CB  . LYS   A 1 266 ? -53.534 -28.209 -3.475  1.00 39.77  ? 639 LYS   A CB  1 
ATOM   1813 C CG  . LYS   A 1 266 ? -53.663 -26.859 -4.154  1.00 45.80  ? 639 LYS   A CG  1 
ATOM   1814 C CD  . LYS   A 1 266 ? -54.003 -25.685 -3.245  1.00 48.75  ? 639 LYS   A CD  1 
ATOM   1815 C CE  . LYS   A 1 266 ? -54.214 -24.458 -4.069  1.00 53.02  ? 639 LYS   A CE  1 
ATOM   1816 N NZ  . LYS   A 1 266 ? -54.447 -23.289 -3.219  1.00 58.71  ? 639 LYS   A NZ  1 
ATOM   1817 N N   . VAL   A 1 267 ? -51.835 -30.930 -3.073  1.00 40.95  ? 640 VAL   A N   1 
ATOM   1818 C CA  . VAL   A 1 267 ? -51.630 -31.999 -2.119  1.00 41.48  ? 640 VAL   A CA  1 
ATOM   1819 C C   . VAL   A 1 267 ? -51.541 -31.392 -0.723  1.00 44.55  ? 640 VAL   A C   1 
ATOM   1820 O O   . VAL   A 1 267 ? -52.150 -31.894 0.208   1.00 45.92  ? 640 VAL   A O   1 
ATOM   1821 C CB  . VAL   A 1 267 ? -50.357 -32.778 -2.475  1.00 39.25  ? 640 VAL   A CB  1 
ATOM   1822 C CG1 . VAL   A 1 267 ? -50.087 -33.935 -1.510  1.00 41.84  ? 640 VAL   A CG1 1 
ATOM   1823 C CG2 . VAL   A 1 267 ? -50.440 -33.271 -3.905  1.00 39.14  ? 640 VAL   A CG2 1 
ATOM   1824 N N   . SER   A 1 268 ? -50.765 -30.320 -0.574  1.00 46.24  ? 641 SER   A N   1 
ATOM   1825 C CA  . SER   A 1 268 ? -50.709 -29.619 0.697   1.00 44.93  ? 641 SER   A CA  1 
ATOM   1826 C C   . SER   A 1 268 ? -50.380 -28.152 0.453   1.00 45.34  ? 641 SER   A C   1 
ATOM   1827 O O   . SER   A 1 268 ? -49.939 -27.764 -0.628  1.00 40.57  ? 641 SER   A O   1 
ATOM   1828 C CB  . SER   A 1 268 ? -49.743 -30.266 1.666   1.00 47.14  ? 641 SER   A CB  1 
ATOM   1829 O OG  . SER   A 1 268 ? -48.443 -30.428 1.105   1.00 48.60  ? 641 SER   A OG  1 
ATOM   1830 N N   . GLU   A 1 269 ? -50.618 -27.349 1.487   1.00 42.69  ? 642 GLU   A N   1 
ATOM   1831 C CA  . GLU   A 1 269 ? -50.563 -25.907 1.382   1.00 44.07  ? 642 GLU   A CA  1 
ATOM   1832 C C   . GLU   A 1 269 ? -50.306 -25.374 2.782   1.00 46.26  ? 642 GLU   A C   1 
ATOM   1833 O O   . GLU   A 1 269 ? -50.911 -25.844 3.741   1.00 45.21  ? 642 GLU   A O   1 
ATOM   1834 C CB  . GLU   A 1 269 ? -51.881 -25.425 0.782   1.00 44.99  ? 642 GLU   A CB  1 
ATOM   1835 C CG  . GLU   A 1 269 ? -51.943 -23.913 0.622   1.00 54.64  ? 642 GLU   A CG  1 
ATOM   1836 C CD  . GLU   A 1 269 ? -53.249 -23.393 0.057   1.00 63.41  ? 642 GLU   A CD  1 
ATOM   1837 O OE1 . GLU   A 1 269 ? -54.191 -24.206 -0.141  1.00 61.60  ? 642 GLU   A OE1 1 
ATOM   1838 O OE2 . GLU   A 1 269 ? -53.305 -22.157 -0.174  1.00 73.47  ? 642 GLU   A OE2 1 
ATOM   1839 N N   . TYR   A 1 270 ? -49.363 -24.442 2.880   1.00 46.34  ? 643 TYR   A N   1 
ATOM   1840 C CA  . TYR   A 1 270 ? -48.988 -23.830 4.137   1.00 46.13  ? 643 TYR   A CA  1 
ATOM   1841 C C   . TYR   A 1 270 ? -48.748 -22.347 3.889   1.00 49.23  ? 643 TYR   A C   1 
ATOM   1842 O O   . TYR   A 1 270 ? -48.253 -21.959 2.826   1.00 44.73  ? 643 TYR   A O   1 
ATOM   1843 C CB  . TYR   A 1 270 ? -47.744 -24.511 4.711   1.00 50.87  ? 643 TYR   A CB  1 
ATOM   1844 C CG  . TYR   A 1 270 ? -47.917 -26.009 4.901   1.00 58.26  ? 643 TYR   A CG  1 
ATOM   1845 C CD1 . TYR   A 1 270 ? -48.519 -26.509 6.050   1.00 66.16  ? 643 TYR   A CD1 1 
ATOM   1846 C CD2 . TYR   A 1 270 ? -47.528 -26.924 3.922   1.00 61.19  ? 643 TYR   A CD2 1 
ATOM   1847 C CE1 . TYR   A 1 270 ? -48.706 -27.869 6.233   1.00 66.60  ? 643 TYR   A CE1 1 
ATOM   1848 C CE2 . TYR   A 1 270 ? -47.702 -28.290 4.098   1.00 58.98  ? 643 TYR   A CE2 1 
ATOM   1849 C CZ  . TYR   A 1 270 ? -48.293 -28.761 5.259   1.00 64.32  ? 643 TYR   A CZ  1 
ATOM   1850 O OH  . TYR   A 1 270 ? -48.492 -30.086 5.487   1.00 69.52  ? 643 TYR   A OH  1 
ATOM   1851 N N   . SER   A 1 271 ? -49.130 -21.535 4.879   1.00 45.09  ? 644 SER   A N   1 
ATOM   1852 C CA  . SER   A 1 271 ? -48.743 -20.139 4.927   1.00 45.00  ? 644 SER   A CA  1 
ATOM   1853 C C   . SER   A 1 271 ? -47.471 -20.040 5.746   1.00 42.57  ? 644 SER   A C   1 
ATOM   1854 O O   . SER   A 1 271 ? -47.528 -20.204 6.955   1.00 49.50  ? 644 SER   A O   1 
ATOM   1855 C CB  . SER   A 1 271 ? -49.842 -19.282 5.524   1.00 45.65  ? 644 SER   A CB  1 
ATOM   1856 O OG  . SER   A 1 271 ? -50.986 -19.307 4.686   1.00 42.88  ? 644 SER   A OG  1 
ATOM   1857 N N   . LEU   A 1 272 ? -46.331 -19.794 5.092   1.00 41.68  ? 645 LEU   A N   1 
ATOM   1858 C CA  . LEU   A 1 272 ? -45.083 -19.654 5.816   1.00 40.49  ? 645 LEU   A CA  1 
ATOM   1859 C C   . LEU   A 1 272 ? -45.068 -18.297 6.512   1.00 39.68  ? 645 LEU   A C   1 
ATOM   1860 O O   . LEU   A 1 272 ? -45.804 -17.380 6.133   1.00 36.54  ? 645 LEU   A O   1 
ATOM   1861 C CB  . LEU   A 1 272 ? -43.888 -19.814 4.875   1.00 44.39  ? 645 LEU   A CB  1 
ATOM   1862 C CG  . LEU   A 1 272 ? -43.677 -21.225 4.312   1.00 43.84  ? 645 LEU   A CG  1 
ATOM   1863 C CD1 . LEU   A 1 272 ? -42.467 -21.317 3.414   1.00 45.34  ? 645 LEU   A CD1 1 
ATOM   1864 C CD2 . LEU   A 1 272 ? -43.562 -22.251 5.405   1.00 46.24  ? 645 LEU   A CD2 1 
ATOM   1865 N N   . PRO   A 1 273 ? -44.220 -18.124 7.547   1.00 38.79  ? 646 PRO   A N   1 
ATOM   1866 C CA  . PRO   A 1 273 ? -43.971 -16.792 8.097   1.00 42.59  ? 646 PRO   A CA  1 
ATOM   1867 C C   . PRO   A 1 273 ? -43.611 -15.859 6.941   1.00 43.93  ? 646 PRO   A C   1 
ATOM   1868 O O   . PRO   A 1 273 ? -43.003 -16.285 5.955   1.00 41.31  ? 646 PRO   A O   1 
ATOM   1869 C CB  . PRO   A 1 273 ? -42.822 -16.985 9.101   1.00 43.81  ? 646 PRO   A CB  1 
ATOM   1870 C CG  . PRO   A 1 273 ? -42.826 -18.480 9.415   1.00 42.61  ? 646 PRO   A CG  1 
ATOM   1871 C CD  . PRO   A 1 273 ? -43.458 -19.182 8.222   1.00 40.27  ? 646 PRO   A CD  1 
ATOM   1872 N N   . SER   A 1 274 ? -43.979 -14.580 7.070   1.00 42.55  ? 647 SER   A N   1 
ATOM   1873 C CA  . SER   A 1 274 ? -43.769 -13.631 5.988   1.00 44.50  ? 647 SER   A CA  1 
ATOM   1874 C C   . SER   A 1 274 ? -42.279 -13.418 5.721   1.00 36.77  ? 647 SER   A C   1 
ATOM   1875 O O   . SER   A 1 274 ? -41.914 -13.054 4.612   1.00 45.09  ? 647 SER   A O   1 
ATOM   1876 C CB  . SER   A 1 274 ? -44.478 -12.327 6.246   1.00 46.45  ? 647 SER   A CB  1 
ATOM   1877 O OG  . SER   A 1 274 ? -43.921 -11.711 7.390   1.00 56.00  ? 647 SER   A OG  1 
ATOM   1878 N N   . ASP   A 1 275 ? -41.419 -13.665 6.713   1.00 34.92  ? 648 ASP   A N   1 
ATOM   1879 C CA  . ASP   A 1 275 ? -39.984 -13.539 6.523   1.00 36.25  ? 648 ASP   A CA  1 
ATOM   1880 C C   . ASP   A 1 275 ? -39.376 -14.707 5.718   1.00 38.33  ? 648 ASP   A C   1 
ATOM   1881 O O   . ASP   A 1 275 ? -38.159 -14.743 5.511   1.00 34.98  ? 648 ASP   A O   1 
ATOM   1882 C CB  . ASP   A 1 275 ? -39.287 -13.289 7.853   1.00 39.45  ? 648 ASP   A CB  1 
ATOM   1883 C CG  . ASP   A 1 275 ? -39.314 -14.409 8.886   1.00 43.31  ? 648 ASP   A CG  1 
ATOM   1884 O OD1 . ASP   A 1 275 ? -40.082 -15.380 8.697   1.00 43.66  ? 648 ASP   A OD1 1 
ATOM   1885 O OD2 . ASP   A 1 275 ? -38.535 -14.310 9.865   1.00 42.67  ? 648 ASP   A OD2 1 
ATOM   1886 N N   . ALA   A 1 276 ? -40.199 -15.687 5.315   1.00 35.67  ? 649 ALA   A N   1 
ATOM   1887 C CA  . ALA   A 1 276 ? -39.785 -16.687 4.348   1.00 35.09  ? 649 ALA   A CA  1 
ATOM   1888 C C   . ALA   A 1 276 ? -39.808 -16.131 2.926   1.00 34.99  ? 649 ALA   A C   1 
ATOM   1889 O O   . ALA   A 1 276 ? -39.021 -16.606 2.107   1.00 34.75  ? 649 ALA   A O   1 
ATOM   1890 C CB  . ALA   A 1 276 ? -40.651 -17.923 4.454   1.00 38.16  ? 649 ALA   A CB  1 
ATOM   1891 N N   . THR   A 1 277 ? -40.681 -15.141 2.640   1.00 34.14  ? 650 THR   A N   1 
ATOM   1892 C CA  . THR   A 1 277 ? -40.893 -14.674 1.277   1.00 35.50  ? 650 THR   A CA  1 
ATOM   1893 C C   . THR   A 1 277 ? -40.620 -13.183 1.124   1.00 37.95  ? 650 THR   A C   1 
ATOM   1894 O O   . THR   A 1 277 ? -40.582 -12.689 -0.006  1.00 38.76  ? 650 THR   A O   1 
ATOM   1895 C CB  . THR   A 1 277 ? -42.298 -14.998 0.780   1.00 37.09  ? 650 THR   A CB  1 
ATOM   1896 O OG1 . THR   A 1 277 ? -43.185 -14.474 1.756   1.00 41.94  ? 650 THR   A OG1 1 
ATOM   1897 C CG2 . THR   A 1 277 ? -42.509 -16.491 0.596   1.00 37.42  ? 650 THR   A CG2 1 
ATOM   1898 N N   . GLY   A 1 278 ? -40.392 -12.476 2.230   1.00 37.00  ? 651 GLY   A N   1 
ATOM   1899 C CA  . GLY   A 1 278 ? -40.038 -11.070 2.118   1.00 40.42  ? 651 GLY   A CA  1 
ATOM   1900 C C   . GLY   A 1 278 ? -41.263 -10.242 1.728   1.00 42.66  ? 651 GLY   A C   1 
ATOM   1901 O O   . GLY   A 1 278 ? -42.389 -10.692 1.906   1.00 45.62  ? 651 GLY   A O   1 
ATOM   1902 N N   . PRO   A 1 279 ? -41.124 -9.035  1.137   1.00 47.41  ? 652 PRO   A N   1 
ATOM   1903 C CA  . PRO   A 1 279 ? -39.838 -8.495  0.696   1.00 45.30  ? 652 PRO   A CA  1 
ATOM   1904 C C   . PRO   A 1 279 ? -38.913 -8.337  1.889   1.00 42.01  ? 652 PRO   A C   1 
ATOM   1905 O O   . PRO   A 1 279 ? -39.378 -8.142  3.001   1.00 44.91  ? 652 PRO   A O   1 
ATOM   1906 C CB  . PRO   A 1 279 ? -40.164 -7.137  0.053   1.00 51.55  ? 652 PRO   A CB  1 
ATOM   1907 C CG  . PRO   A 1 279 ? -41.678 -7.150  -0.154  1.00 53.68  ? 652 PRO   A CG  1 
ATOM   1908 C CD  . PRO   A 1 279 ? -42.250 -8.121  0.867   1.00 50.35  ? 652 PRO   A CD  1 
ATOM   1909 N N   . PHE   A 1 280 ? -37.608 -8.451  1.643   1.00 40.38  ? 653 PHE   A N   1 
ATOM   1910 C CA  . PHE   A 1 280 ? -36.624 -8.492  2.710   1.00 40.02  ? 653 PHE   A CA  1 
ATOM   1911 C C   . PHE   A 1 280 ? -36.097 -7.072  2.922   1.00 41.26  ? 653 PHE   A C   1 
ATOM   1912 O O   . PHE   A 1 280 ? -35.654 -6.437  1.966   1.00 42.00  ? 653 PHE   A O   1 
ATOM   1913 C CB  . PHE   A 1 280 ? -35.533 -9.491  2.293   1.00 40.03  ? 653 PHE   A CB  1 
ATOM   1914 C CG  . PHE   A 1 280 ? -36.006 -10.903 1.941   1.00 39.30  ? 653 PHE   A CG  1 
ATOM   1915 C CD1 . PHE   A 1 280 ? -36.712 -11.677 2.856   1.00 38.35  ? 653 PHE   A CD1 1 
ATOM   1916 C CD2 . PHE   A 1 280 ? -35.778 -11.436 0.676   1.00 37.63  ? 653 PHE   A CD2 1 
ATOM   1917 C CE1 . PHE   A 1 280 ? -37.139 -12.956 2.530   1.00 41.39  ? 653 PHE   A CE1 1 
ATOM   1918 C CE2 . PHE   A 1 280 ? -36.214 -12.709 0.351   1.00 38.79  ? 653 PHE   A CE2 1 
ATOM   1919 C CZ  . PHE   A 1 280 ? -36.901 -13.466 1.277   1.00 38.32  ? 653 PHE   A CZ  1 
ATOM   1920 N N   . VAL   A 1 281 ? -36.117 -6.604  4.176   1.00 40.34  ? 654 VAL   A N   1 
ATOM   1921 C CA  . VAL   A 1 281 ? -35.836 -5.215  4.510   1.00 43.13  ? 654 VAL   A CA  1 
ATOM   1922 C C   . VAL   A 1 281 ? -34.736 -5.139  5.563   1.00 43.02  ? 654 VAL   A C   1 
ATOM   1923 O O   . VAL   A 1 281 ? -34.867 -5.725  6.633   1.00 42.30  ? 654 VAL   A O   1 
ATOM   1924 C CB  . VAL   A 1 281 ? -37.100 -4.505  5.026   1.00 41.02  ? 654 VAL   A CB  1 
ATOM   1925 C CG1 . VAL   A 1 281 ? -36.798 -3.058  5.433   1.00 40.45  ? 654 VAL   A CG1 1 
ATOM   1926 C CG2 . VAL   A 1 281 ? -38.232 -4.568  4.002   1.00 41.28  ? 654 VAL   A CG2 1 
ATOM   1927 N N   . LEU   A 1 282 ? -33.676 -4.388  5.249   1.00 43.41  ? 655 LEU   A N   1 
ATOM   1928 C CA  . LEU   A 1 282 ? -32.667 -4.010  6.226   1.00 49.27  ? 655 LEU   A CA  1 
ATOM   1929 C C   . LEU   A 1 282 ? -32.722 -2.490  6.417   1.00 50.24  ? 655 LEU   A C   1 
ATOM   1930 O O   . LEU   A 1 282 ? -32.416 -1.750  5.484   1.00 47.86  ? 655 LEU   A O   1 
ATOM   1931 C CB  . LEU   A 1 282 ? -31.302 -4.482  5.728   1.00 47.95  ? 655 LEU   A CB  1 
ATOM   1932 C CG  . LEU   A 1 282 ? -30.109 -4.264  6.667   1.00 47.23  ? 655 LEU   A CG  1 
ATOM   1933 C CD1 . LEU   A 1 282 ? -30.263 -4.930  8.029   1.00 48.92  ? 655 LEU   A CD1 1 
ATOM   1934 C CD2 . LEU   A 1 282 ? -28.838 -4.740  5.990   1.00 43.78  ? 655 LEU   A CD2 1 
ATOM   1935 N N   . SER   A 1 283 ? -33.160 -2.039  7.606   1.00 51.94  ? 656 SER   A N   1 
ATOM   1936 C CA  . SER   A 1 283 ? -33.355 -0.616  7.892   1.00 60.30  ? 656 SER   A CA  1 
ATOM   1937 C C   . SER   A 1 283 ? -32.081 0.018   8.472   1.00 53.57  ? 656 SER   A C   1 
ATOM   1938 O O   . SER   A 1 283 ? -31.470 -0.656  9.329   1.00 52.27  ? 656 SER   A O   1 
ATOM   1939 C CB  . SER   A 1 283 ? -34.520 -0.398  8.824   1.00 61.76  ? 656 SER   A CB  1 
ATOM   1940 O OG  . SER   A 1 283 ? -35.736 -0.812  8.212   1.00 62.57  ? 656 SER   A OG  1 
ATOM   1941 N N   . TYR   A 1 285 ? -28.113 3.696   11.083  1.00 107.17 ? 658 TYR   A N   1 
ATOM   1942 C CA  . TYR   A 1 285 ? -28.717 5.047   10.906  1.00 108.97 ? 658 TYR   A CA  1 
ATOM   1943 C C   . TYR   A 1 285 ? -30.229 4.905   10.756  1.00 102.48 ? 658 TYR   A C   1 
ATOM   1944 O O   . TYR   A 1 285 ? -30.774 3.809   10.890  1.00 101.23 ? 658 TYR   A O   1 
ATOM   1945 C CB  . TYR   A 1 285 ? -28.103 5.771   9.701   1.00 104.56 ? 658 TYR   A CB  1 
ATOM   1946 N N   . SER   A 1 286 ? -30.888 6.039   10.492  1.00 99.47  ? 659 SER   A N   1 
ATOM   1947 C CA  . SER   A 1 286 ? -32.306 6.070   10.176  1.00 90.25  ? 659 SER   A CA  1 
ATOM   1948 C C   . SER   A 1 286 ? -32.502 6.761   8.827   1.00 88.14  ? 659 SER   A C   1 
ATOM   1949 O O   . SER   A 1 286 ? -31.547 7.284   8.236   1.00 77.12  ? 659 SER   A O   1 
ATOM   1950 C CB  . SER   A 1 286 ? -33.110 6.728   11.283  1.00 82.94  ? 659 SER   A CB  1 
ATOM   1951 N N   . GLY   A 1 287 ? -33.755 6.703   8.345   1.00 83.14  ? 660 GLY   A N   1 
ATOM   1952 C CA  . GLY   A 1 287 ? -34.152 7.230   7.051   1.00 80.14  ? 660 GLY   A CA  1 
ATOM   1953 C C   . GLY   A 1 287 ? -34.010 6.188   5.941   1.00 70.75  ? 660 GLY   A C   1 
ATOM   1954 O O   . GLY   A 1 287 ? -34.897 6.050   5.104   1.00 69.72  ? 660 GLY   A O   1 
ATOM   1955 N N   . TYR   A 1 288 ? -32.886 5.462   5.953   1.00 59.84  ? 661 TYR   A N   1 
ATOM   1956 C CA  . TYR   A 1 288 ? -32.457 4.644   4.830   1.00 62.47  ? 661 TYR   A CA  1 
ATOM   1957 C C   . TYR   A 1 288 ? -32.840 3.186   5.062   1.00 61.02  ? 661 TYR   A C   1 
ATOM   1958 O O   . TYR   A 1 288 ? -32.611 2.651   6.147   1.00 70.38  ? 661 TYR   A O   1 
ATOM   1959 C CB  . TYR   A 1 288 ? -30.935 4.776   4.720   1.00 55.18  ? 661 TYR   A CB  1 
ATOM   1960 C CG  . TYR   A 1 288 ? -30.337 4.354   3.391   1.00 54.37  ? 661 TYR   A CG  1 
ATOM   1961 C CD1 . TYR   A 1 288 ? -30.460 5.171   2.277   1.00 53.16  ? 661 TYR   A CD1 1 
ATOM   1962 C CD2 . TYR   A 1 288 ? -29.618 3.169   3.257   1.00 57.22  ? 661 TYR   A CD2 1 
ATOM   1963 C CE1 . TYR   A 1 288 ? -29.894 4.824   1.064   1.00 58.27  ? 661 TYR   A CE1 1 
ATOM   1964 C CE2 . TYR   A 1 288 ? -29.057 2.804   2.043   1.00 55.17  ? 661 TYR   A CE2 1 
ATOM   1965 C CZ  . TYR   A 1 288 ? -29.198 3.634   0.944   1.00 65.32  ? 661 TYR   A CZ  1 
ATOM   1966 O OH  . TYR   A 1 288 ? -28.642 3.318   -0.267  1.00 76.02  ? 661 TYR   A OH  1 
ATOM   1967 N N   . LYS   A 1 289 ? -33.388 2.542   4.032   1.00 52.15  ? 662 LYS   A N   1 
ATOM   1968 C CA  . LYS   A 1 289 ? -33.602 1.107   4.090   1.00 54.59  ? 662 LYS   A CA  1 
ATOM   1969 C C   . LYS   A 1 289 ? -33.236 0.482   2.751   1.00 51.02  ? 662 LYS   A C   1 
ATOM   1970 O O   . LYS   A 1 289 ? -33.284 1.133   1.715   1.00 51.64  ? 662 LYS   A O   1 
ATOM   1971 C CB  . LYS   A 1 289 ? -35.025 0.750   4.547   1.00 52.90  ? 662 LYS   A CB  1 
ATOM   1972 C CG  . LYS   A 1 289 ? -36.133 1.174   3.617   1.00 55.93  ? 662 LYS   A CG  1 
ATOM   1973 C CD  . LYS   A 1 289 ? -37.539 0.826   4.092   1.00 59.81  ? 662 LYS   A CD  1 
ATOM   1974 C CE  . LYS   A 1 289 ? -38.549 1.180   3.035   1.00 65.05  ? 662 LYS   A CE  1 
ATOM   1975 N NZ  . LYS   A 1 289 ? -39.925 0.846   3.414   1.00 68.85  ? 662 LYS   A NZ  1 
ATOM   1976 N N   . GLN   A 1 290 ? -32.853 -0.796  2.826   1.00 52.97  ? 663 GLN   A N   1 
ATOM   1977 C CA  . GLN   A 1 290 ? -32.599 -1.647  1.676   1.00 46.94  ? 663 GLN   A CA  1 
ATOM   1978 C C   . GLN   A 1 290 ? -33.727 -2.665  1.573   1.00 39.92  ? 663 GLN   A C   1 
ATOM   1979 O O   . GLN   A 1 290 ? -34.121 -3.258  2.573   1.00 39.99  ? 663 GLN   A O   1 
ATOM   1980 C CB  . GLN   A 1 290 ? -31.211 -2.248  1.887   1.00 50.61  ? 663 GLN   A CB  1 
ATOM   1981 C CG  . GLN   A 1 290 ? -30.113 -1.195  1.780   1.00 54.38  ? 663 GLN   A CG  1 
ATOM   1982 C CD  . GLN   A 1 290 ? -28.749 -1.667  2.231   1.00 61.02  ? 663 GLN   A CD  1 
ATOM   1983 O OE1 . GLN   A 1 290 ? -28.616 -2.576  3.052   1.00 58.97  ? 663 GLN   A OE1 1 
ATOM   1984 N NE2 . GLN   A 1 290 ? -27.714 -1.004  1.733   1.00 73.04  ? 663 GLN   A NE2 1 
ATOM   1985 N N   . VAL   A 1 291 ? -34.252 -2.843  0.356   1.00 42.69  ? 664 VAL   A N   1 
ATOM   1986 C CA  . VAL   A 1 291 ? -35.393 -3.712  0.119   1.00 42.82  ? 664 VAL   A CA  1 
ATOM   1987 C C   . VAL   A 1 291 ? -35.016 -4.694  -0.991  1.00 45.16  ? 664 VAL   A C   1 
ATOM   1988 O O   . VAL   A 1 291 ? -34.561 -4.273  -2.049  1.00 39.94  ? 664 VAL   A O   1 
ATOM   1989 C CB  . VAL   A 1 291 ? -36.639 -2.874  -0.228  1.00 45.47  ? 664 VAL   A CB  1 
ATOM   1990 C CG1 . VAL   A 1 291 ? -37.842 -3.735  -0.591  1.00 44.16  ? 664 VAL   A CG1 1 
ATOM   1991 C CG2 . VAL   A 1 291 ? -37.008 -1.903  0.896   1.00 44.78  ? 664 VAL   A CG2 1 
ATOM   1992 N N   . GLN   A 1 292 ? -35.157 -6.006  -0.722  1.00 45.29  ? 665 GLN   A N   1 
ATOM   1993 C CA  . GLN   A 1 292 ? -34.817 -7.042  -1.689  1.00 42.78  ? 665 GLN   A CA  1 
ATOM   1994 C C   . GLN   A 1 292 ? -36.030 -7.942  -1.881  1.00 40.61  ? 665 GLN   A C   1 
ATOM   1995 O O   . GLN   A 1 292 ? -36.548 -8.512  -0.921  1.00 42.47  ? 665 GLN   A O   1 
ATOM   1996 C CB  . GLN   A 1 292 ? -33.597 -7.861  -1.263  1.00 45.82  ? 665 GLN   A CB  1 
ATOM   1997 C CG  . GLN   A 1 292 ? -33.011 -8.716  -2.384  1.00 50.45  ? 665 GLN   A CG  1 
ATOM   1998 C CD  . GLN   A 1 292 ? -31.625 -9.257  -2.085  1.00 61.50  ? 665 GLN   A CD  1 
ATOM   1999 O OE1 . GLN   A 1 292 ? -31.006 -8.967  -1.052  1.00 57.59  ? 665 GLN   A OE1 1 
ATOM   2000 N NE2 . GLN   A 1 292 ? -31.114 -10.063 -3.005  1.00 75.37  ? 665 GLN   A NE2 1 
ATOM   2001 N N   . VAL   A 1 293 ? -36.496 -8.043  -3.125  1.00 42.64  ? 666 VAL   A N   1 
ATOM   2002 C CA  . VAL   A 1 293 ? -37.552 -8.985  -3.467  1.00 45.82  ? 666 VAL   A CA  1 
ATOM   2003 C C   . VAL   A 1 293 ? -36.881 -10.320 -3.784  1.00 41.94  ? 666 VAL   A C   1 
ATOM   2004 O O   . VAL   A 1 293 ? -35.740 -10.339 -4.243  1.00 36.57  ? 666 VAL   A O   1 
ATOM   2005 C CB  . VAL   A 1 293 ? -38.429 -8.506  -4.639  1.00 52.26  ? 666 VAL   A CB  1 
ATOM   2006 C CG1 . VAL   A 1 293 ? -39.257 -7.286  -4.251  1.00 55.41  ? 666 VAL   A CG1 1 
ATOM   2007 C CG2 . VAL   A 1 293 ? -37.608 -8.221  -5.893  1.00 54.03  ? 666 VAL   A CG2 1 
ATOM   2008 N N   . PRO   A 1 294 ? -37.547 -11.470 -3.534  1.00 37.43  ? 667 PRO   A N   1 
ATOM   2009 C CA  . PRO   A 1 294 ? -36.939 -12.770 -3.805  1.00 40.68  ? 667 PRO   A CA  1 
ATOM   2010 C C   . PRO   A 1 294 ? -36.441 -12.851 -5.243  1.00 39.30  ? 667 PRO   A C   1 
ATOM   2011 O O   . PRO   A 1 294 ? -37.145 -12.466 -6.172  1.00 42.91  ? 667 PRO   A O   1 
ATOM   2012 C CB  . PRO   A 1 294 ? -38.055 -13.757 -3.516  1.00 38.91  ? 667 PRO   A CB  1 
ATOM   2013 C CG  . PRO   A 1 294 ? -38.870 -13.029 -2.497  1.00 39.35  ? 667 PRO   A CG  1 
ATOM   2014 C CD  . PRO   A 1 294 ? -38.904 -11.587 -2.996  1.00 38.47  ? 667 PRO   A CD  1 
ATOM   2015 N N   . ARG   A 1 295 ? -35.201 -13.307 -5.398  1.00 36.83  ? 668 ARG   A N   1 
ATOM   2016 C CA  . ARG   A 1 295 ? -34.585 -13.465 -6.707  1.00 42.66  ? 668 ARG   A CA  1 
ATOM   2017 C C   . ARG   A 1 295 ? -33.868 -14.816 -6.753  1.00 42.43  ? 668 ARG   A C   1 
ATOM   2018 O O   . ARG   A 1 295 ? -33.946 -15.527 -7.751  1.00 42.40  ? 668 ARG   A O   1 
ATOM   2019 C CB  . ARG   A 1 295 ? -33.661 -12.254 -6.897  1.00 46.64  ? 668 ARG   A CB  1 
ATOM   2020 C CG  . ARG   A 1 295 ? -32.888 -12.103 -8.200  1.00 52.58  ? 668 ARG   A CG  1 
ATOM   2021 C CD  . ARG   A 1 295 ? -33.678 -11.503 -9.357  1.00 53.55  ? 668 ARG   A CD  1 
ATOM   2022 N NE  . ARG   A 1 295 ? -34.659 -12.449 -9.887  1.00 51.09  ? 668 ARG   A NE  1 
ATOM   2023 C CZ  . ARG   A 1 295 ? -34.392 -13.617 -10.484 1.00 51.28  ? 668 ARG   A CZ  1 
ATOM   2024 N NH1 . ARG   A 1 295 ? -33.145 -13.914 -10.866 1.00 43.30  ? 668 ARG   A NH1 1 
ATOM   2025 N NH2 . ARG   A 1 295 ? -35.399 -14.467 -10.703 1.00 47.42  ? 668 ARG   A NH2 1 
ATOM   2026 N N   . GLY   A 1 296 ? -33.160 -15.153 -5.664  1.00 41.82  ? 669 GLY   A N   1 
ATOM   2027 C CA  . GLY   A 1 296 ? -32.542 -16.461 -5.524  1.00 43.03  ? 669 GLY   A CA  1 
ATOM   2028 C C   . GLY   A 1 296 ? -33.527 -17.505 -5.003  1.00 40.53  ? 669 GLY   A C   1 
ATOM   2029 O O   . GLY   A 1 296 ? -34.682 -17.199 -4.728  1.00 44.45  ? 669 GLY   A O   1 
ATOM   2030 N N   A ARG   A 1 297 ? -33.024 -18.733 -4.858  0.50 37.21  ? 670 ARG   A N   1 
ATOM   2031 N N   B ARG   A 1 297 ? -33.038 -18.741 -4.903  0.50 36.24  ? 670 ARG   A N   1 
ATOM   2032 C CA  A ARG   A 1 297 ? -33.730 -19.884 -4.305  0.50 36.12  ? 670 ARG   A CA  1 
ATOM   2033 C CA  B ARG   A 1 297 ? -33.782 -19.839 -4.309  0.50 34.70  ? 670 ARG   A CA  1 
ATOM   2034 C C   A ARG   A 1 297 ? -34.197 -19.635 -2.867  0.50 33.29  ? 670 ARG   A C   1 
ATOM   2035 C C   B ARG   A 1 297 ? -34.231 -19.490 -2.893  0.50 32.84  ? 670 ARG   A C   1 
ATOM   2036 O O   A ARG   A 1 297 ? -33.373 -19.416 -1.987  0.50 30.39  ? 670 ARG   A O   1 
ATOM   2037 O O   B ARG   A 1 297 ? -33.442 -19.032 -2.076  0.50 30.01  ? 670 ARG   A O   1 
ATOM   2038 C CB  A ARG   A 1 297 ? -32.627 -20.947 -4.401  0.50 35.28  ? 670 ARG   A CB  1 
ATOM   2039 C CB  B ARG   A 1 297 ? -32.894 -21.080 -4.194  0.50 33.20  ? 670 ARG   A CB  1 
ATOM   2040 C CG  A ARG   A 1 297 ? -32.876 -22.384 -3.969  0.50 40.61  ? 670 ARG   A CG  1 
ATOM   2041 C CG  B ARG   A 1 297 ? -32.504 -21.675 -5.533  0.50 35.83  ? 670 ARG   A CG  1 
ATOM   2042 C CD  A ARG   A 1 297 ? -31.648 -23.156 -4.431  0.50 41.94  ? 670 ARG   A CD  1 
ATOM   2043 C CD  B ARG   A 1 297 ? -32.712 -23.178 -5.498  0.50 37.44  ? 670 ARG   A CD  1 
ATOM   2044 N NE  A ARG   A 1 297 ? -31.467 -24.526 -3.952  0.50 43.53  ? 670 ARG   A NE  1 
ATOM   2045 N NE  B ARG   A 1 297 ? -34.051 -23.473 -6.010  0.50 37.47  ? 670 ARG   A NE  1 
ATOM   2046 C CZ  A ARG   A 1 297 ? -31.319 -25.582 -4.746  0.50 43.18  ? 670 ARG   A CZ  1 
ATOM   2047 C CZ  B ARG   A 1 297 ? -34.628 -24.648 -5.906  0.50 36.16  ? 670 ARG   A CZ  1 
ATOM   2048 N NH1 A ARG   A 1 297 ? -30.756 -26.679 -4.277  0.50 38.88  ? 670 ARG   A NH1 1 
ATOM   2049 N NH1 B ARG   A 1 297 ? -34.160 -25.534 -5.035  0.50 38.59  ? 670 ARG   A NH1 1 
ATOM   2050 N NH2 A ARG   A 1 297 ? -31.647 -25.506 -6.026  0.50 44.93  ? 670 ARG   A NH2 1 
ATOM   2051 N NH2 B ARG   A 1 297 ? -35.683 -24.908 -6.652  0.50 32.90  ? 670 ARG   A NH2 1 
ATOM   2052 N N   . LEU   A 1 298 ? -35.515 -19.711 -2.618  1.00 32.18  ? 671 LEU   A N   1 
ATOM   2053 C CA  . LEU   A 1 298 ? -36.066 -19.455 -1.295  1.00 33.42  ? 671 LEU   A CA  1 
ATOM   2054 C C   . LEU   A 1 298 ? -36.160 -20.730 -0.464  1.00 32.80  ? 671 LEU   A C   1 
ATOM   2055 O O   . LEU   A 1 298 ? -36.382 -20.630 0.732   1.00 34.67  ? 671 LEU   A O   1 
ATOM   2056 C CB  . LEU   A 1 298 ? -37.446 -18.810 -1.386  1.00 32.80  ? 671 LEU   A CB  1 
ATOM   2057 C CG  . LEU   A 1 298 ? -37.494 -17.386 -1.939  1.00 35.22  ? 671 LEU   A CG  1 
ATOM   2058 C CD1 . LEU   A 1 298 ? -38.942 -16.911 -1.927  1.00 36.57  ? 671 LEU   A CD1 1 
ATOM   2059 C CD2 . LEU   A 1 298 ? -36.579 -16.451 -1.162  1.00 34.52  ? 671 LEU   A CD2 1 
ATOM   2060 N N   . PHE   A 1 299 ? -36.100 -21.910 -1.092  1.00 31.46  ? 672 PHE   A N   1 
ATOM   2061 C CA  . PHE   A 1 299 ? -36.195 -23.160 -0.353  1.00 34.16  ? 672 PHE   A CA  1 
ATOM   2062 C C   . PHE   A 1 299 ? -35.162 -24.132 -0.914  1.00 33.92  ? 672 PHE   A C   1 
ATOM   2063 O O   . PHE   A 1 299 ? -34.776 -24.013 -2.063  1.00 34.67  ? 672 PHE   A O   1 
ATOM   2064 C CB  . PHE   A 1 299 ? -37.624 -23.716 -0.326  1.00 34.29  ? 672 PHE   A CB  1 
ATOM   2065 C CG  . PHE   A 1 299 ? -38.320 -24.092 -1.631  1.00 34.71  ? 672 PHE   A CG  1 
ATOM   2066 C CD1 . PHE   A 1 299 ? -37.624 -24.460 -2.774  1.00 40.04  ? 672 PHE   A CD1 1 
ATOM   2067 C CD2 . PHE   A 1 299 ? -39.704 -24.118 -1.696  1.00 39.40  ? 672 PHE   A CD2 1 
ATOM   2068 C CE1 . PHE   A 1 299 ? -38.292 -24.812 -3.939  1.00 37.99  ? 672 PHE   A CE1 1 
ATOM   2069 C CE2 . PHE   A 1 299 ? -40.369 -24.455 -2.866  1.00 36.50  ? 672 PHE   A CE2 1 
ATOM   2070 C CZ  . PHE   A 1 299 ? -39.663 -24.805 -3.985  1.00 36.72  ? 672 PHE   A CZ  1 
ATOM   2071 N N   . ALA   A 1 300 ? -34.670 -25.036 -0.064  1.00 35.27  ? 673 ALA   A N   1 
ATOM   2072 C CA  . ALA   A 1 300 ? -33.808 -26.127 -0.490  1.00 33.87  ? 673 ALA   A CA  1 
ATOM   2073 C C   . ALA   A 1 300 ? -34.117 -27.373 0.340   1.00 37.78  ? 673 ALA   A C   1 
ATOM   2074 O O   . ALA   A 1 300 ? -34.714 -27.276 1.410   1.00 38.65  ? 673 ALA   A O   1 
ATOM   2075 C CB  . ALA   A 1 300 ? -32.360 -25.714 -0.388  1.00 33.57  ? 673 ALA   A CB  1 
ATOM   2076 N N   . PHE   A 1 301 ? -33.700 -28.541 -0.163  1.00 41.15  ? 674 PHE   A N   1 
ATOM   2077 C CA  . PHE   A 1 301 ? -34.129 -29.823 0.373   1.00 40.12  ? 674 PHE   A CA  1 
ATOM   2078 C C   . PHE   A 1 301 ? -32.939 -30.716 0.691   1.00 39.52  ? 674 PHE   A C   1 
ATOM   2079 O O   . PHE   A 1 301 ? -31.898 -30.585 0.076   1.00 38.88  ? 674 PHE   A O   1 
ATOM   2080 C CB  . PHE   A 1 301 ? -35.035 -30.500 -0.652  1.00 38.56  ? 674 PHE   A CB  1 
ATOM   2081 C CG  . PHE   A 1 301 ? -36.202 -29.595 -1.000  1.00 42.36  ? 674 PHE   A CG  1 
ATOM   2082 C CD1 . PHE   A 1 301 ? -36.095 -28.665 -2.032  1.00 46.65  ? 674 PHE   A CD1 1 
ATOM   2083 C CD2 . PHE   A 1 301 ? -37.370 -29.623 -0.251  1.00 40.30  ? 674 PHE   A CD2 1 
ATOM   2084 C CE1 . PHE   A 1 301 ? -37.155 -27.821 -2.332  1.00 49.26  ? 674 PHE   A CE1 1 
ATOM   2085 C CE2 . PHE   A 1 301 ? -38.425 -28.781 -0.557  1.00 43.20  ? 674 PHE   A CE2 1 
ATOM   2086 C CZ  . PHE   A 1 301 ? -38.317 -27.877 -1.590  1.00 47.32  ? 674 PHE   A CZ  1 
ATOM   2087 N N   . ASP   A 1 302 ? -33.117 -31.638 1.649   1.00 42.97  ? 675 ASP   A N   1 
ATOM   2088 C CA  . ASP   A 1 302 ? -32.109 -32.646 1.938   1.00 47.40  ? 675 ASP   A CA  1 
ATOM   2089 C C   . ASP   A 1 302 ? -32.136 -33.680 0.820   1.00 47.45  ? 675 ASP   A C   1 
ATOM   2090 O O   . ASP   A 1 302 ? -33.012 -33.650 -0.043  1.00 50.93  ? 675 ASP   A O   1 
ATOM   2091 C CB  . ASP   A 1 302 ? -32.300 -33.271 3.311   1.00 49.29  ? 675 ASP   A CB  1 
ATOM   2092 C CG  . ASP   A 1 302 ? -33.385 -34.332 3.393   1.00 48.75  ? 675 ASP   A CG  1 
ATOM   2093 O OD1 . ASP   A 1 302 ? -34.543 -34.007 3.063   1.00 44.19  ? 675 ASP   A OD1 1 
ATOM   2094 O OD2 . ASP   A 1 302 ? -33.052 -35.486 3.750   1.00 63.01  ? 675 ASP   A OD2 1 
ATOM   2095 N N   . SER   A 1 303 ? -31.176 -34.603 0.843   1.00 55.25  ? 676 SER   A N   1 
ATOM   2096 C CA  . SER   A 1 303 ? -30.888 -35.434 -0.320  1.00 57.35  ? 676 SER   A CA  1 
ATOM   2097 C C   . SER   A 1 303 ? -32.087 -36.297 -0.708  1.00 51.80  ? 676 SER   A C   1 
ATOM   2098 O O   . SER   A 1 303 ? -32.244 -36.612 -1.883  1.00 59.21  ? 676 SER   A O   1 
ATOM   2099 C CB  . SER   A 1 303 ? -29.647 -36.274 -0.109  1.00 58.56  ? 676 SER   A CB  1 
ATOM   2100 O OG  . SER   A 1 303 ? -29.760 -37.083 1.055   1.00 55.01  ? 676 SER   A OG  1 
ATOM   2101 N N   . GLU   A 1 304 ? -32.936 -36.638 0.266   1.00 55.85  ? 677 GLU   A N   1 
ATOM   2102 C CA  . GLU   A 1 304 ? -34.041 -37.564 0.061   1.00 66.06  ? 677 GLU   A CA  1 
ATOM   2103 C C   . GLU   A 1 304 ? -35.368 -36.812 0.016   1.00 58.20  ? 677 GLU   A C   1 
ATOM   2104 O O   . GLU   A 1 304 ? -36.415 -37.420 -0.190  1.00 61.25  ? 677 GLU   A O   1 
ATOM   2105 C CB  . GLU   A 1 304 ? -34.126 -38.585 1.199   1.00 80.26  ? 677 GLU   A CB  1 
ATOM   2106 C CG  . GLU   A 1 304 ? -32.842 -39.373 1.466   1.00 91.32  ? 677 GLU   A CG  1 
ATOM   2107 C CD  . GLU   A 1 304 ? -32.549 -40.527 0.518   1.00 97.56  ? 677 GLU   A CD  1 
ATOM   2108 O OE1 . GLU   A 1 304 ? -33.469 -41.347 0.290   1.00 94.20  ? 677 GLU   A OE1 1 
ATOM   2109 O OE2 . GLU   A 1 304 ? -31.396 -40.625 0.035   1.00 95.82  ? 677 GLU   A OE2 1 
ATOM   2110 N N   . GLY   A 1 305 ? -35.330 -35.496 0.244   1.00 53.69  ? 678 GLY   A N   1 
ATOM   2111 C CA  . GLY   A 1 305 ? -36.512 -34.666 0.079   1.00 45.05  ? 678 GLY   A CA  1 
ATOM   2112 C C   . GLY   A 1 305 ? -37.481 -34.814 1.247   1.00 44.77  ? 678 GLY   A C   1 
ATOM   2113 O O   . GLY   A 1 305 ? -38.684 -34.669 1.067   1.00 43.34  ? 678 GLY   A O   1 
ATOM   2114 N N   . ASN   A 1 306 ? -36.942 -35.066 2.448   1.00 45.75  ? 679 ASN   A N   1 
ATOM   2115 C CA  . ASN   A 1 306 ? -37.748 -35.210 3.649   1.00 44.77  ? 679 ASN   A CA  1 
ATOM   2116 C C   . ASN   A 1 306 ? -37.795 -33.914 4.460   1.00 44.27  ? 679 ASN   A C   1 
ATOM   2117 O O   . ASN   A 1 306 ? -38.746 -33.709 5.217   1.00 50.55  ? 679 ASN   A O   1 
ATOM   2118 C CB  . ASN   A 1 306 ? -37.257 -36.385 4.491   1.00 53.26  ? 679 ASN   A CB  1 
ATOM   2119 C CG  . ASN   A 1 306 ? -37.635 -37.703 3.858   1.00 51.31  ? 679 ASN   A CG  1 
ATOM   2120 O OD1 . ASN   A 1 306 ? -38.823 -37.993 3.685   1.00 55.20  ? 679 ASN   A OD1 1 
ATOM   2121 N ND2 . ASN   A 1 306 ? -36.648 -38.481 3.455   1.00 49.16  ? 679 ASN   A ND2 1 
ATOM   2122 N N   . TYR   A 1 307 ? -36.793 -33.037 4.293   1.00 40.35  ? 680 TYR   A N   1 
ATOM   2123 C CA  . TYR   A 1 307 ? -36.713 -31.788 5.036   1.00 42.17  ? 680 TYR   A CA  1 
ATOM   2124 C C   . TYR   A 1 307 ? -36.479 -30.612 4.087   1.00 42.52  ? 680 TYR   A C   1 
ATOM   2125 O O   . TYR   A 1 307 ? -35.886 -30.766 3.017   1.00 37.60  ? 680 TYR   A O   1 
ATOM   2126 C CB  . TYR   A 1 307 ? -35.598 -31.899 6.084   1.00 45.80  ? 680 TYR   A CB  1 
ATOM   2127 C CG  . TYR   A 1 307 ? -35.896 -32.932 7.162   1.00 50.14  ? 680 TYR   A CG  1 
ATOM   2128 C CD1 . TYR   A 1 307 ? -36.596 -32.585 8.311   1.00 54.66  ? 680 TYR   A CD1 1 
ATOM   2129 C CD2 . TYR   A 1 307 ? -35.535 -34.267 7.000   1.00 52.22  ? 680 TYR   A CD2 1 
ATOM   2130 C CE1 . TYR   A 1 307 ? -36.901 -33.527 9.284   1.00 58.62  ? 680 TYR   A CE1 1 
ATOM   2131 C CE2 . TYR   A 1 307 ? -35.827 -35.215 7.966   1.00 56.78  ? 680 TYR   A CE2 1 
ATOM   2132 C CZ  . TYR   A 1 307 ? -36.512 -34.844 9.110   1.00 58.92  ? 680 TYR   A CZ  1 
ATOM   2133 O OH  . TYR   A 1 307 ? -36.804 -35.771 10.063  1.00 63.06  ? 680 TYR   A OH  1 
ATOM   2134 N N   . MET   A 1 308 ? -36.910 -29.421 4.524   1.00 41.47  ? 681 MET   A N   1 
ATOM   2135 C CA  . MET   A 1 308 ? -36.871 -28.223 3.699   1.00 36.38  ? 681 MET   A CA  1 
ATOM   2136 C C   . MET   A 1 308 ? -36.323 -27.058 4.508   1.00 36.21  ? 681 MET   A C   1 
ATOM   2137 O O   . MET   A 1 308 ? -36.840 -26.753 5.576   1.00 34.78  ? 681 MET   A O   1 
ATOM   2138 C CB  . MET   A 1 308 ? -38.261 -27.824 3.206   1.00 37.63  ? 681 MET   A CB  1 
ATOM   2139 C CG  . MET   A 1 308 ? -38.238 -26.587 2.321   1.00 36.29  ? 681 MET   A CG  1 
ATOM   2140 S SD  . MET   A 1 308 ? -39.862 -26.201 1.661   1.00 37.91  ? 681 MET   A SD  1 
ATOM   2141 C CE  . MET   A 1 308 ? -40.871 -25.749 3.080   1.00 38.38  ? 681 MET   A CE  1 
ATOM   2142 N N   . LEU   A 1 309 ? -35.280 -26.424 3.964   1.00 35.67  ? 682 LEU   A N   1 
ATOM   2143 C CA  . LEU   A 1 309 ? -34.699 -25.212 4.505   1.00 35.41  ? 682 LEU   A CA  1 
ATOM   2144 C C   . LEU   A 1 309 ? -35.368 -23.981 3.884   1.00 38.95  ? 682 LEU   A C   1 
ATOM   2145 O O   . LEU   A 1 309 ? -35.549 -23.940 2.671   1.00 35.20  ? 682 LEU   A O   1 
ATOM   2146 C CB  . LEU   A 1 309 ? -33.223 -25.288 4.142   1.00 32.21  ? 682 LEU   A CB  1 
ATOM   2147 C CG  . LEU   A 1 309 ? -32.384 -24.060 4.491   1.00 31.91  ? 682 LEU   A CG  1 
ATOM   2148 C CD1 . LEU   A 1 309 ? -32.340 -23.843 6.001   1.00 32.78  ? 682 LEU   A CD1 1 
ATOM   2149 C CD2 . LEU   A 1 309 ? -31.002 -24.242 3.924   1.00 31.23  ? 682 LEU   A CD2 1 
ATOM   2150 N N   . THR   A 1 310 ? -35.690 -22.984 4.729   1.00 38.51  ? 683 THR   A N   1 
ATOM   2151 C CA  . THR   A 1 310 ? -36.348 -21.748 4.330   1.00 37.69  ? 683 THR   A CA  1 
ATOM   2152 C C   . THR   A 1 310 ? -35.640 -20.568 4.982   1.00 34.80  ? 683 THR   A C   1 
ATOM   2153 O O   . THR   A 1 310 ? -34.792 -20.746 5.843   1.00 33.92  ? 683 THR   A O   1 
ATOM   2154 C CB  . THR   A 1 310 ? -37.833 -21.752 4.708   1.00 38.94  ? 683 THR   A CB  1 
ATOM   2155 O OG1 . THR   A 1 310 ? -37.934 -21.743 6.127   1.00 36.41  ? 683 THR   A OG1 1 
ATOM   2156 C CG2 . THR   A 1 310 ? -38.577 -22.949 4.154   1.00 39.61  ? 683 THR   A CG2 1 
ATOM   2157 N N   . CYS   A 1 311 ? -35.969 -19.366 4.505   1.00 35.41  ? 684 CYS   A N   1 
ATOM   2158 C CA  . CYS   A 1 311 ? -35.377 -18.125 4.983   1.00 35.45  ? 684 CYS   A CA  1 
ATOM   2159 C C   . CYS   A 1 311 ? -36.097 -17.660 6.255   1.00 34.99  ? 684 CYS   A C   1 
ATOM   2160 O O   . CYS   A 1 311 ? -37.286 -17.895 6.394   1.00 35.27  ? 684 CYS   A O   1 
ATOM   2161 C CB  . CYS   A 1 311 ? -35.537 -17.021 3.933   1.00 35.92  ? 684 CYS   A CB  1 
ATOM   2162 S SG  . CYS   A 1 311 ? -34.680 -17.323 2.361   1.00 33.57  ? 684 CYS   A SG  1 
ATOM   2163 N N   . SER   A 1 312 ? -35.395 -16.967 7.157   1.00 36.46  ? 685 SER   A N   1 
ATOM   2164 C CA  . SER   A 1 312 ? -36.055 -16.159 8.170   1.00 40.38  ? 685 SER   A CA  1 
ATOM   2165 C C   . SER   A 1 312 ? -35.159 -14.992 8.551   1.00 39.16  ? 685 SER   A C   1 
ATOM   2166 O O   . SER   A 1 312 ? -34.001 -14.938 8.151   1.00 39.48  ? 685 SER   A O   1 
ATOM   2167 C CB  . SER   A 1 312 ? -36.409 -16.948 9.413   1.00 41.56  ? 685 SER   A CB  1 
ATOM   2168 O OG  . SER   A 1 312 ? -35.270 -17.029 10.262  1.00 38.64  ? 685 SER   A OG  1 
ATOM   2169 N N   . ALA   A 1 313 ? -35.706 -14.093 9.377   1.00 39.94  ? 686 ALA   A N   1 
ATOM   2170 C CA  . ALA   A 1 313 ? -35.017 -12.864 9.732   1.00 44.62  ? 686 ALA   A CA  1 
ATOM   2171 C C   . ALA   A 1 313 ? -33.664 -13.170 10.372  1.00 42.88  ? 686 ALA   A C   1 
ATOM   2172 O O   . ALA   A 1 313 ? -32.727 -12.400 10.189  1.00 47.08  ? 686 ALA   A O   1 
ATOM   2173 C CB  . ALA   A 1 313 ? -35.899 -12.017 10.641  1.00 46.91  ? 686 ALA   A CB  1 
ATOM   2174 N N   . THR   A 1 314 ? -33.543 -14.309 11.074  1.00 41.89  ? 687 THR   A N   1 
ATOM   2175 C CA  . THR   A 1 314 ? -32.372 -14.539 11.910  1.00 47.10  ? 687 THR   A CA  1 
ATOM   2176 C C   . THR   A 1 314 ? -31.608 -15.797 11.504  1.00 46.32  ? 687 THR   A C   1 
ATOM   2177 O O   . THR   A 1 314 ? -30.589 -16.111 12.118  1.00 48.44  ? 687 THR   A O   1 
ATOM   2178 C CB  . THR   A 1 314 ? -32.788 -14.582 13.384  1.00 50.58  ? 687 THR   A CB  1 
ATOM   2179 O OG1 . THR   A 1 314 ? -33.691 -15.666 13.584  1.00 47.24  ? 687 THR   A OG1 1 
ATOM   2180 C CG2 . THR   A 1 314 ? -33.452 -13.284 13.817  1.00 51.11  ? 687 THR   A CG2 1 
ATOM   2181 N N   . GLY   A 1 315 ? -32.087 -16.514 10.481  1.00 46.20  ? 688 GLY   A N   1 
ATOM   2182 C CA  . GLY   A 1 315 ? -31.384 -17.696 10.012  1.00 42.13  ? 688 GLY   A CA  1 
ATOM   2183 C C   . GLY   A 1 315 ? -32.296 -18.658 9.258   1.00 40.63  ? 688 GLY   A C   1 
ATOM   2184 O O   . GLY   A 1 315 ? -33.508 -18.448 9.124   1.00 39.73  ? 688 GLY   A O   1 
ATOM   2185 N N   . GLY   A 1 316 ? -31.670 -19.717 8.749   1.00 38.67  ? 689 GLY   A N   1 
ATOM   2186 C CA  . GLY   A 1 316 ? -32.396 -20.796 8.109   1.00 40.48  ? 689 GLY   A CA  1 
ATOM   2187 C C   . GLY   A 1 316 ? -33.312 -21.516 9.091   1.00 41.40  ? 689 GLY   A C   1 
ATOM   2188 O O   . GLY   A 1 316 ? -32.945 -21.748 10.244  1.00 42.21  ? 689 GLY   A O   1 
ATOM   2189 N N   . VAL   A 1 317 ? -34.499 -21.872 8.598   1.00 40.09  ? 690 VAL   A N   1 
ATOM   2190 C CA  . VAL   A 1 317 ? -35.486 -22.606 9.366   1.00 41.43  ? 690 VAL   A CA  1 
ATOM   2191 C C   . VAL   A 1 317 ? -35.864 -23.843 8.567   1.00 40.32  ? 690 VAL   A C   1 
ATOM   2192 O O   . VAL   A 1 317 ? -36.282 -23.722 7.413   1.00 39.15  ? 690 VAL   A O   1 
ATOM   2193 C CB  . VAL   A 1 317 ? -36.727 -21.744 9.657   1.00 43.28  ? 690 VAL   A CB  1 
ATOM   2194 C CG1 . VAL   A 1 317 ? -37.829 -22.570 10.309  1.00 44.11  ? 690 VAL   A CG1 1 
ATOM   2195 C CG2 . VAL   A 1 317 ? -36.380 -20.527 10.508  1.00 42.67  ? 690 VAL   A CG2 1 
ATOM   2196 N N   . ILE   A 1 318 ? -35.719 -25.012 9.202   1.00 40.54  ? 691 ILE   A N   1 
ATOM   2197 C CA  . ILE   A 1 318 ? -35.923 -26.296 8.549   1.00 39.66  ? 691 ILE   A CA  1 
ATOM   2198 C C   . ILE   A 1 318 ? -37.232 -26.924 9.027   1.00 38.02  ? 691 ILE   A C   1 
ATOM   2199 O O   . ILE   A 1 318 ? -37.525 -26.944 10.216  1.00 42.70  ? 691 ILE   A O   1 
ATOM   2200 C CB  . ILE   A 1 318 ? -34.710 -27.208 8.791   1.00 37.27  ? 691 ILE   A CB  1 
ATOM   2201 C CG1 . ILE   A 1 318 ? -33.480 -26.658 8.093   1.00 38.14  ? 691 ILE   A CG1 1 
ATOM   2202 C CG2 . ILE   A 1 318 ? -35.008 -28.645 8.357   1.00 44.73  ? 691 ILE   A CG2 1 
ATOM   2203 C CD1 . ILE   A 1 318 ? -32.170 -27.317 8.495   1.00 35.58  ? 691 ILE   A CD1 1 
ATOM   2204 N N   . TYR   A 1 319 ? -38.007 -27.439 8.074   1.00 39.48  ? 692 TYR   A N   1 
ATOM   2205 C CA  . TYR   A 1 319 ? -39.257 -28.129 8.332   1.00 42.91  ? 692 TYR   A CA  1 
ATOM   2206 C C   . TYR   A 1 319 ? -39.166 -29.569 7.837   1.00 46.30  ? 692 TYR   A C   1 
ATOM   2207 O O   . TYR   A 1 319 ? -38.464 -29.854 6.867   1.00 49.02  ? 692 TYR   A O   1 
ATOM   2208 C CB  . TYR   A 1 319 ? -40.410 -27.463 7.578   1.00 43.53  ? 692 TYR   A CB  1 
ATOM   2209 C CG  . TYR   A 1 319 ? -40.664 -26.005 7.936   1.00 46.52  ? 692 TYR   A CG  1 
ATOM   2210 C CD1 . TYR   A 1 319 ? -41.480 -25.653 9.007   1.00 46.50  ? 692 TYR   A CD1 1 
ATOM   2211 C CD2 . TYR   A 1 319 ? -40.093 -24.979 7.195   1.00 45.56  ? 692 TYR   A CD2 1 
ATOM   2212 C CE1 . TYR   A 1 319 ? -41.725 -24.326 9.322   1.00 46.03  ? 692 TYR   A CE1 1 
ATOM   2213 C CE2 . TYR   A 1 319 ? -40.328 -23.651 7.499   1.00 44.36  ? 692 TYR   A CE2 1 
ATOM   2214 C CZ  . TYR   A 1 319 ? -41.153 -23.321 8.557   1.00 44.77  ? 692 TYR   A CZ  1 
ATOM   2215 O OH  . TYR   A 1 319 ? -41.373 -22.004 8.836   1.00 38.43  ? 692 TYR   A OH  1 
ATOM   2216 N N   . LYS   A 1 320 ? -39.903 -30.469 8.499   1.00 48.32  ? 693 LYS   A N   1 
ATOM   2217 C CA  . LYS   A 1 320 ? -40.124 -31.812 7.986   1.00 52.46  ? 693 LYS   A CA  1 
ATOM   2218 C C   . LYS   A 1 320 ? -41.296 -31.750 7.013   1.00 51.22  ? 693 LYS   A C   1 
ATOM   2219 O O   . LYS   A 1 320 ? -42.324 -31.148 7.325   1.00 51.75  ? 693 LYS   A O   1 
ATOM   2220 C CB  . LYS   A 1 320 ? -40.389 -32.832 9.106   1.00 57.05  ? 693 LYS   A CB  1 
ATOM   2221 C CG  . LYS   A 1 320 ? -39.879 -34.253 8.854   1.00 56.74  ? 693 LYS   A CG  1 
ATOM   2222 N N   . LEU   A 1 321 ? -41.099 -32.326 5.820   1.00 50.63  ? 694 LEU   A N   1 
ATOM   2223 C CA  . LEU   A 1 321 ? -42.160 -32.441 4.833   1.00 54.95  ? 694 LEU   A CA  1 
ATOM   2224 C C   . LEU   A 1 321 ? -42.999 -33.688 5.126   1.00 65.74  ? 694 LEU   A C   1 
ATOM   2225 O O   . LEU   A 1 321 ? -42.601 -34.542 5.925   1.00 57.76  ? 694 LEU   A O   1 
ATOM   2226 C CB  . LEU   A 1 321 ? -41.533 -32.500 3.440   1.00 55.44  ? 694 LEU   A CB  1 
ATOM   2227 C CG  . LEU   A 1 321 ? -40.664 -31.301 3.029   1.00 55.28  ? 694 LEU   A CG  1 
ATOM   2228 C CD1 . LEU   A 1 321 ? -40.027 -31.540 1.677   1.00 52.29  ? 694 LEU   A CD1 1 
ATOM   2229 C CD2 . LEU   A 1 321 ? -41.465 -30.014 3.001   1.00 55.98  ? 694 LEU   A CD2 1 
ATOM   2230 N N   . GLY   A 1 322 ? -44.178 -33.757 4.488   1.00 77.96  ? 695 GLY   A N   1 
ATOM   2231 C CA  . GLY   A 1 322 ? -44.994 -34.962 4.450   1.00 82.02  ? 695 GLY   A CA  1 
ATOM   2232 C C   . GLY   A 1 322 ? -45.876 -35.135 5.688   1.00 80.50  ? 695 GLY   A C   1 
ATOM   2233 O O   . GLY   A 1 322 ? -46.553 -36.149 5.811   1.00 77.22  ? 695 GLY   A O   1 
ATOM   2234 N N   . GLY   A 1 323 ? -45.877 -34.149 6.594   1.00 85.37  ? 696 GLY   A N   1 
ATOM   2235 C CA  . GLY   A 1 323 ? -46.651 -34.230 7.823   1.00 87.90  ? 696 GLY   A CA  1 
ATOM   2236 C C   . GLY   A 1 323 ? -48.127 -33.949 7.561   1.00 92.03  ? 696 GLY   A C   1 
ATOM   2237 O O   . GLY   A 1 323 ? -48.486 -33.398 6.523   1.00 84.34  ? 696 GLY   A O   1 
ATOM   2238 N N   . ASP   A 1 324 ? -48.975 -34.349 8.514   1.00 105.83 ? 697 ASP   A N   1 
ATOM   2239 C CA  . ASP   A 1 324 ? -50.410 -34.129 8.416   1.00 112.12 ? 697 ASP   A CA  1 
ATOM   2240 C C   . ASP   A 1 324 ? -50.781 -32.782 9.042   1.00 117.59 ? 697 ASP   A C   1 
ATOM   2241 O O   . ASP   A 1 324 ? -51.827 -32.229 8.708   1.00 127.23 ? 697 ASP   A O   1 
ATOM   2242 C CB  . ASP   A 1 324 ? -51.192 -35.287 9.022   1.00 107.63 ? 697 ASP   A CB  1 
ATOM   2243 N N   . GLU   A 1 325 ? -49.925 -32.258 9.937   1.00 108.92 ? 698 GLU   A N   1 
ATOM   2244 C CA  . GLU   A 1 325 ? -50.221 -31.049 10.696  1.00 103.76 ? 698 GLU   A CA  1 
ATOM   2245 C C   . GLU   A 1 325 ? -50.637 -29.924 9.746   1.00 107.79 ? 698 GLU   A C   1 
ATOM   2246 O O   . GLU   A 1 325 ? -50.077 -29.785 8.659   1.00 108.97 ? 698 GLU   A O   1 
ATOM   2247 C CB  . GLU   A 1 325 ? -49.025 -30.648 11.562  1.00 94.15  ? 698 GLU   A CB  1 
ATOM   2248 N N   . LYS   A 1 326 ? -51.634 -29.132 10.173  1.00 102.36 ? 699 LYS   A N   1 
ATOM   2249 C CA  . LYS   A 1 326 ? -52.228 -28.089 9.349   1.00 100.63 ? 699 LYS   A CA  1 
ATOM   2250 C C   . LYS   A 1 326 ? -51.357 -26.832 9.373   1.00 98.09  ? 699 LYS   A C   1 
ATOM   2251 O O   . LYS   A 1 326 ? -51.393 -26.051 8.424   1.00 88.56  ? 699 LYS   A O   1 
ATOM   2252 C CB  . LYS   A 1 326 ? -53.662 -27.794 9.809   1.00 98.73  ? 699 LYS   A CB  1 
ATOM   2253 N N   . VAL   A 1 327 ? -50.605 -26.634 10.470  1.00 95.97  ? 700 VAL   A N   1 
ATOM   2254 C CA  . VAL   A 1 327 ? -49.609 -25.575 10.580  1.00 95.69  ? 700 VAL   A CA  1 
ATOM   2255 C C   . VAL   A 1 327 ? -48.223 -26.218 10.588  1.00 94.58  ? 700 VAL   A C   1 
ATOM   2256 O O   . VAL   A 1 327 ? -47.961 -27.089 11.415  1.00 92.19  ? 700 VAL   A O   1 
ATOM   2257 C CB  . VAL   A 1 327 ? -49.820 -24.723 11.847  1.00 93.99  ? 700 VAL   A CB  1 
ATOM   2258 N N   . LEU   A 1 328 ? -47.346 -25.789 9.666   1.00 92.38  ? 701 LEU   A N   1 
ATOM   2259 C CA  . LEU   A 1 328 ? -45.993 -26.330 9.590   1.00 94.24  ? 701 LEU   A CA  1 
ATOM   2260 C C   . LEU   A 1 328 ? -45.209 -25.867 10.817  1.00 96.30  ? 701 LEU   A C   1 
ATOM   2261 O O   . LEU   A 1 328 ? -45.117 -24.664 11.067  1.00 97.97  ? 701 LEU   A O   1 
ATOM   2262 C CB  . LEU   A 1 328 ? -45.257 -25.948 8.301   1.00 93.47  ? 701 LEU   A CB  1 
ATOM   2263 C CG  . LEU   A 1 328 ? -45.120 -27.032 7.220   1.00 89.00  ? 701 LEU   A CG  1 
ATOM   2264 C CD1 . LEU   A 1 328 ? -44.176 -26.540 6.126   1.00 81.85  ? 701 LEU   A CD1 1 
ATOM   2265 C CD2 . LEU   A 1 328 ? -44.654 -28.390 7.750   1.00 85.51  ? 701 LEU   A CD2 1 
ATOM   2266 N N   . GLU   A 1 329 ? -44.650 -26.833 11.564  1.00 88.97  ? 702 GLU   A N   1 
ATOM   2267 C CA  . GLU   A 1 329 ? -43.840 -26.540 12.738  1.00 80.64  ? 702 GLU   A CA  1 
ATOM   2268 C C   . GLU   A 1 329 ? -42.367 -26.755 12.391  1.00 67.36  ? 702 GLU   A C   1 
ATOM   2269 O O   . GLU   A 1 329 ? -41.986 -27.801 11.858  1.00 60.37  ? 702 GLU   A O   1 
ATOM   2270 C CB  . GLU   A 1 329 ? -44.245 -27.344 13.978  1.00 74.75  ? 702 GLU   A CB  1 
ATOM   2271 N N   . SER   A 1 330 ? -41.580 -25.713 12.687  1.00 65.46  ? 703 SER   A N   1 
ATOM   2272 C CA  . SER   A 1 330 ? -40.129 -25.697 12.604  1.00 67.80  ? 703 SER   A CA  1 
ATOM   2273 C C   . SER   A 1 330 ? -39.526 -26.846 13.408  1.00 65.79  ? 703 SER   A C   1 
ATOM   2274 O O   . SER   A 1 330 ? -39.830 -26.983 14.586  1.00 71.44  ? 703 SER   A O   1 
ATOM   2275 C CB  . SER   A 1 330 ? -39.611 -24.357 13.108  1.00 65.27  ? 703 SER   A CB  1 
ATOM   2276 O OG  . SER   A 1 330 ? -38.255 -24.442 13.531  1.00 73.17  ? 703 SER   A OG  1 
ATOM   2277 N N   . CYS   A 1 331 ? -38.631 -27.628 12.794  1.00 61.49  ? 704 CYS   A N   1 
ATOM   2278 C CA  . CYS   A 1 331 ? -37.962 -28.704 13.508  1.00 57.71  ? 704 CYS   A CA  1 
ATOM   2279 C C   . CYS   A 1 331 ? -36.498 -28.357 13.806  1.00 58.04  ? 704 CYS   A C   1 
ATOM   2280 O O   . CYS   A 1 331 ? -35.887 -28.976 14.676  1.00 54.53  ? 704 CYS   A O   1 
ATOM   2281 C CB  . CYS   A 1 331 ? -38.115 -30.019 12.757  1.00 62.53  ? 704 CYS   A CB  1 
ATOM   2282 S SG  . CYS   A 1 331 ? -36.827 -30.301 11.520  1.00 70.87  ? 704 CYS   A SG  1 
ATOM   2283 N N   . LEU   A 1 332 ? -35.920 -27.370 13.106  1.00 54.05  ? 705 LEU   A N   1 
ATOM   2284 C CA  . LEU   A 1 332 ? -34.567 -26.939 13.413  1.00 49.18  ? 705 LEU   A CA  1 
ATOM   2285 C C   . LEU   A 1 332 ? -34.335 -25.523 12.896  1.00 50.63  ? 705 LEU   A C   1 
ATOM   2286 O O   . LEU   A 1 332 ? -34.659 -25.218 11.749  1.00 52.32  ? 705 LEU   A O   1 
ATOM   2287 C CB  . LEU   A 1 332 ? -33.563 -27.924 12.815  1.00 49.05  ? 705 LEU   A CB  1 
ATOM   2288 C CG  . LEU   A 1 332 ? -32.088 -27.571 13.034  1.00 54.71  ? 705 LEU   A CG  1 
ATOM   2289 C CD1 . LEU   A 1 332 ? -31.801 -27.573 14.526  1.00 59.88  ? 705 LEU   A CD1 1 
ATOM   2290 C CD2 . LEU   A 1 332 ? -31.127 -28.497 12.306  1.00 55.40  ? 705 LEU   A CD2 1 
ATOM   2291 N N   . SER   A 1 333 ? -33.758 -24.670 13.755  1.00 48.56  ? 706 SER   A N   1 
ATOM   2292 C CA  . SER   A 1 333 ? -33.437 -23.295 13.412  1.00 47.81  ? 706 SER   A CA  1 
ATOM   2293 C C   . SER   A 1 333 ? -31.928 -23.112 13.513  1.00 48.93  ? 706 SER   A C   1 
ATOM   2294 O O   . SER   A 1 333 ? -31.382 -23.209 14.606  1.00 51.69  ? 706 SER   A O   1 
ATOM   2295 C CB  . SER   A 1 333 ? -34.159 -22.312 14.305  1.00 47.88  ? 706 SER   A CB  1 
ATOM   2296 O OG  . SER   A 1 333 ? -35.569 -22.418 14.153  1.00 52.69  ? 706 SER   A OG  1 
ATOM   2297 N N   . LEU   A 1 334 ? -31.277 -22.831 12.377  1.00 43.31  ? 707 LEU   A N   1 
ATOM   2298 C CA  . LEU   A 1 334 ? -29.823 -22.799 12.299  1.00 44.97  ? 707 LEU   A CA  1 
ATOM   2299 C C   . LEU   A 1 334 ? -29.264 -21.486 12.839  1.00 43.23  ? 707 LEU   A C   1 
ATOM   2300 O O   . LEU   A 1 334 ? -28.080 -21.417 13.144  1.00 43.40  ? 707 LEU   A O   1 
ATOM   2301 C CB  . LEU   A 1 334 ? -29.352 -22.988 10.859  1.00 44.10  ? 707 LEU   A CB  1 
ATOM   2302 C CG  . LEU   A 1 334 ? -29.930 -24.176 10.093  1.00 44.68  ? 707 LEU   A CG  1 
ATOM   2303 C CD1 . LEU   A 1 334 ? -29.213 -24.303 8.757   1.00 44.87  ? 707 LEU   A CD1 1 
ATOM   2304 C CD2 . LEU   A 1 334 ? -29.817 -25.456 10.890  1.00 47.80  ? 707 LEU   A CD2 1 
ATOM   2305 N N   . GLY   A 1 335 ? -30.086 -20.429 12.854  1.00 42.66  ? 708 GLY   A N   1 
ATOM   2306 C CA  . GLY   A 1 335 ? -29.702 -19.148 13.429  1.00 41.72  ? 708 GLY   A CA  1 
ATOM   2307 C C   . GLY   A 1 335 ? -28.411 -18.585 12.837  1.00 44.04  ? 708 GLY   A C   1 
ATOM   2308 O O   . GLY   A 1 335 ? -27.958 -18.988 11.754  1.00 42.77  ? 708 GLY   A O   1 
ATOM   2309 N N   . GLY   A 1 336 ? -27.857 -17.600 13.556  1.00 46.05  ? 709 GLY   A N   1 
ATOM   2310 C CA  . GLY   A 1 336 ? -26.535 -17.067 13.267  1.00 44.72  ? 709 GLY   A CA  1 
ATOM   2311 C C   . GLY   A 1 336 ? -26.566 -15.778 12.446  1.00 47.44  ? 709 GLY   A C   1 
ATOM   2312 O O   . GLY   A 1 336 ? -25.508 -15.241 12.141  1.00 49.45  ? 709 GLY   A O   1 
ATOM   2313 N N   . HIS   A 1 337 ? -27.752 -15.277 12.069  1.00 44.83  ? 710 HIS   A N   1 
ATOM   2314 C CA  . HIS   A 1 337 ? -27.795 -14.095 11.212  1.00 48.61  ? 710 HIS   A CA  1 
ATOM   2315 C C   . HIS   A 1 337 ? -28.317 -12.883 11.976  1.00 45.82  ? 710 HIS   A C   1 
ATOM   2316 O O   . HIS   A 1 337 ? -29.252 -12.997 12.767  1.00 46.82  ? 710 HIS   A O   1 
ATOM   2317 C CB  . HIS   A 1 337 ? -28.589 -14.333 9.916   1.00 43.57  ? 710 HIS   A CB  1 
ATOM   2318 C CG  . HIS   A 1 337 ? -27.888 -15.234 8.954   1.00 42.23  ? 710 HIS   A CG  1 
ATOM   2319 N ND1 . HIS   A 1 337 ? -27.105 -14.765 7.924   1.00 40.75  ? 710 HIS   A ND1 1 
ATOM   2320 C CD2 . HIS   A 1 337 ? -27.831 -16.578 8.885   1.00 41.59  ? 710 HIS   A CD2 1 
ATOM   2321 C CE1 . HIS   A 1 337 ? -26.603 -15.799 7.258   1.00 43.13  ? 710 HIS   A CE1 1 
ATOM   2322 N NE2 . HIS   A 1 337 ? -27.030 -16.910 7.828   1.00 37.45  ? 710 HIS   A NE2 1 
ATOM   2323 N N   . ARG   A 1 338 ? -27.711 -11.729 11.663  1.00 50.71  ? 711 ARG   A N   1 
ATOM   2324 C CA  . ARG   A 1 338 ? -28.034 -10.436 12.253  1.00 57.88  ? 711 ARG   A CA  1 
ATOM   2325 C C   . ARG   A 1 338 ? -28.724 -9.545  11.213  1.00 53.32  ? 711 ARG   A C   1 
ATOM   2326 O O   . ARG   A 1 338 ? -29.011 -8.383  11.481  1.00 47.14  ? 711 ARG   A O   1 
ATOM   2327 C CB  . ARG   A 1 338 ? -26.749 -9.771  12.778  1.00 59.41  ? 711 ARG   A CB  1 
ATOM   2328 C CG  . ARG   A 1 338 ? -26.046 -10.481 13.933  1.00 60.21  ? 711 ARG   A CG  1 
ATOM   2329 N N   . ALA   A 1 339 ? -28.979 -10.100 10.021  1.00 49.54  ? 712 ALA   A N   1 
ATOM   2330 C CA  . ALA   A 1 339 ? -29.733 -9.439  8.971   1.00 44.72  ? 712 ALA   A CA  1 
ATOM   2331 C C   . ALA   A 1 339 ? -30.568 -10.487 8.245   1.00 43.48  ? 712 ALA   A C   1 
ATOM   2332 O O   . ALA   A 1 339 ? -30.269 -11.673 8.351   1.00 42.06  ? 712 ALA   A O   1 
ATOM   2333 C CB  . ALA   A 1 339 ? -28.791 -8.737  8.029   1.00 48.05  ? 712 ALA   A CB  1 
ATOM   2334 N N   . PRO   A 1 340 ? -31.681 -10.114 7.565   1.00 41.74  ? 713 PRO   A N   1 
ATOM   2335 C CA  . PRO   A 1 340 ? -32.535 -11.103 6.902   1.00 38.82  ? 713 PRO   A CA  1 
ATOM   2336 C C   . PRO   A 1 340 ? -31.815 -12.031 5.929   1.00 37.06  ? 713 PRO   A C   1 
ATOM   2337 O O   . PRO   A 1 340 ? -30.986 -11.592 5.126   1.00 36.94  ? 713 PRO   A O   1 
ATOM   2338 C CB  . PRO   A 1 340 ? -33.559 -10.208 6.195   1.00 40.29  ? 713 PRO   A CB  1 
ATOM   2339 C CG  . PRO   A 1 340 ? -33.691 -9.037  7.146   1.00 40.55  ? 713 PRO   A CG  1 
ATOM   2340 C CD  . PRO   A 1 340 ? -32.250 -8.757  7.508   1.00 38.13  ? 713 PRO   A CD  1 
ATOM   2341 N N   . VAL   A 1 341 ? -32.144 -13.322 6.036   1.00 36.29  ? 714 VAL   A N   1 
ATOM   2342 C CA  . VAL   A 1 341 ? -31.726 -14.321 5.070   1.00 33.55  ? 714 VAL   A CA  1 
ATOM   2343 C C   . VAL   A 1 341 ? -32.642 -14.205 3.861   1.00 32.46  ? 714 VAL   A C   1 
ATOM   2344 O O   . VAL   A 1 341 ? -33.860 -14.167 4.020   1.00 29.13  ? 714 VAL   A O   1 
ATOM   2345 C CB  . VAL   A 1 341 ? -31.778 -15.734 5.685   1.00 35.03  ? 714 VAL   A CB  1 
ATOM   2346 C CG1 . VAL   A 1 341 ? -31.535 -16.818 4.640   1.00 34.07  ? 714 VAL   A CG1 1 
ATOM   2347 C CG2 . VAL   A 1 341 ? -30.803 -15.867 6.861   1.00 35.90  ? 714 VAL   A CG2 1 
ATOM   2348 N N   . VAL   A 1 342 ? -32.037 -14.199 2.665   1.00 31.43  ? 715 VAL   A N   1 
ATOM   2349 C CA  . VAL   A 1 342 ? -32.751 -13.930 1.432   1.00 31.06  ? 715 VAL   A CA  1 
ATOM   2350 C C   . VAL   A 1 342 ? -32.613 -15.079 0.436   1.00 31.63  ? 715 VAL   A C   1 
ATOM   2351 O O   . VAL   A 1 342 ? -33.325 -15.107 -0.567  1.00 30.99  ? 715 VAL   A O   1 
ATOM   2352 C CB  . VAL   A 1 342 ? -32.257 -12.610 0.801   1.00 32.17  ? 715 VAL   A CB  1 
ATOM   2353 C CG1 . VAL   A 1 342 ? -32.455 -11.434 1.741   1.00 36.91  ? 715 VAL   A CG1 1 
ATOM   2354 C CG2 . VAL   A 1 342 ? -30.819 -12.699 0.318   1.00 30.54  ? 715 VAL   A CG2 1 
ATOM   2355 N N   . THR   A 1 343 ? -31.651 -15.979 0.645   1.00 31.90  ? 716 THR   A N   1 
ATOM   2356 C CA  . THR   A 1 343 ? -31.546 -17.157 -0.205  1.00 33.47  ? 716 THR   A CA  1 
ATOM   2357 C C   . THR   A 1 343 ? -30.777 -18.245 0.557   1.00 32.62  ? 716 THR   A C   1 
ATOM   2358 O O   . THR   A 1 343 ? -30.068 -17.972 1.520   1.00 31.42  ? 716 THR   A O   1 
ATOM   2359 C CB  . THR   A 1 343 ? -30.916 -16.787 -1.555  1.00 33.28  ? 716 THR   A CB  1 
ATOM   2360 O OG1 . THR   A 1 343 ? -31.068 -17.880 -2.460  1.00 35.52  ? 716 THR   A OG1 1 
ATOM   2361 C CG2 . THR   A 1 343 ? -29.442 -16.434 -1.436  1.00 34.13  ? 716 THR   A CG2 1 
ATOM   2362 N N   . VAL   A 1 344 ? -30.998 -19.493 0.160   1.00 31.25  ? 717 VAL   A N   1 
ATOM   2363 C CA  . VAL   A 1 344 ? -30.471 -20.653 0.864   1.00 32.90  ? 717 VAL   A CA  1 
ATOM   2364 C C   . VAL   A 1 344 ? -30.027 -21.691 -0.165  1.00 35.89  ? 717 VAL   A C   1 
ATOM   2365 O O   . VAL   A 1 344 ? -30.341 -21.575 -1.353  1.00 33.03  ? 717 VAL   A O   1 
ATOM   2366 C CB  . VAL   A 1 344 ? -31.540 -21.222 1.809   1.00 31.54  ? 717 VAL   A CB  1 
ATOM   2367 C CG1 . VAL   A 1 344 ? -31.952 -20.203 2.866   1.00 32.75  ? 717 VAL   A CG1 1 
ATOM   2368 C CG2 . VAL   A 1 344 ? -32.771 -21.718 1.053   1.00 33.99  ? 717 VAL   A CG2 1 
ATOM   2369 N N   . ASP   A 1 345 ? -29.247 -22.674 0.300   1.00 35.22  ? 718 ASP   A N   1 
ATOM   2370 C CA  . ASP   A 1 345 ? -28.986 -23.878 -0.461  1.00 33.06  ? 718 ASP   A CA  1 
ATOM   2371 C C   . ASP   A 1 345 ? -28.739 -25.027 0.515   1.00 37.04  ? 718 ASP   A C   1 
ATOM   2372 O O   . ASP   A 1 345 ? -28.410 -24.801 1.680   1.00 34.82  ? 718 ASP   A O   1 
ATOM   2373 C CB  . ASP   A 1 345 ? -27.795 -23.720 -1.392  1.00 30.42  ? 718 ASP   A CB  1 
ATOM   2374 C CG  . ASP   A 1 345 ? -27.789 -24.697 -2.559  1.00 31.48  ? 718 ASP   A CG  1 
ATOM   2375 O OD1 . ASP   A 1 345 ? -28.812 -25.396 -2.753  1.00 32.68  ? 718 ASP   A OD1 1 
ATOM   2376 O OD2 . ASP   A 1 345 ? -26.782 -24.753 -3.274  1.00 33.93  ? 718 ASP   A OD2 1 
ATOM   2377 N N   . TRP   A 1 346 ? -28.910 -26.252 0.015   1.00 33.79  ? 719 TRP   A N   1 
ATOM   2378 C CA  . TRP   A 1 346 ? -28.688 -27.451 0.798   1.00 36.28  ? 719 TRP   A CA  1 
ATOM   2379 C C   . TRP   A 1 346 ? -28.098 -28.510 -0.129  1.00 38.06  ? 719 TRP   A C   1 
ATOM   2380 O O   . TRP   A 1 346 ? -28.747 -28.892 -1.093  1.00 36.72  ? 719 TRP   A O   1 
ATOM   2381 C CB  . TRP   A 1 346 ? -30.007 -27.913 1.428   1.00 37.88  ? 719 TRP   A CB  1 
ATOM   2382 C CG  . TRP   A 1 346 ? -29.881 -28.889 2.569   1.00 34.87  ? 719 TRP   A CG  1 
ATOM   2383 C CD1 . TRP   A 1 346 ? -28.816 -29.676 2.905   1.00 38.11  ? 719 TRP   A CD1 1 
ATOM   2384 C CD2 . TRP   A 1 346 ? -30.904 -29.174 3.538   1.00 34.52  ? 719 TRP   A CD2 1 
ATOM   2385 N NE1 . TRP   A 1 346 ? -29.090 -30.406 4.026   1.00 36.09  ? 719 TRP   A NE1 1 
ATOM   2386 C CE2 . TRP   A 1 346 ? -30.367 -30.125 4.435   1.00 37.27  ? 719 TRP   A CE2 1 
ATOM   2387 C CE3 . TRP   A 1 346 ? -32.205 -28.710 3.744   1.00 34.92  ? 719 TRP   A CE3 1 
ATOM   2388 C CZ2 . TRP   A 1 346 ? -31.100 -30.616 5.510   1.00 35.58  ? 719 TRP   A CZ2 1 
ATOM   2389 C CZ3 . TRP   A 1 346 ? -32.926 -29.188 4.812   1.00 35.61  ? 719 TRP   A CZ3 1 
ATOM   2390 C CH2 . TRP   A 1 346 ? -32.381 -30.138 5.678   1.00 38.68  ? 719 TRP   A CH2 1 
ATOM   2391 N N   . SER   A 1 347 ? -26.852 -28.908 0.157   1.00 37.96  ? 720 SER   A N   1 
ATOM   2392 C CA  . SER   A 1 347 ? -26.105 -29.892 -0.606  1.00 42.29  ? 720 SER   A CA  1 
ATOM   2393 C C   . SER   A 1 347 ? -25.692 -31.059 0.302   1.00 42.75  ? 720 SER   A C   1 
ATOM   2394 O O   . SER   A 1 347 ? -25.396 -30.864 1.474   1.00 43.67  ? 720 SER   A O   1 
ATOM   2395 C CB  . SER   A 1 347 ? -24.886 -29.257 -1.209  1.00 43.52  ? 720 SER   A CB  1 
ATOM   2396 O OG  . SER   A 1 347 ? -24.282 -30.138 -2.147  1.00 49.47  ? 720 SER   A OG  1 
ATOM   2397 N N   . THR   A 1 348 ? -25.641 -32.270 -0.249  1.00 55.27  ? 721 THR   A N   1 
ATOM   2398 C CA  . THR   A 1 348 ? -25.140 -33.436 0.477   1.00 65.86  ? 721 THR   A CA  1 
ATOM   2399 C C   . THR   A 1 348 ? -24.024 -34.080 -0.350  1.00 64.34  ? 721 THR   A C   1 
ATOM   2400 O O   . THR   A 1 348 ? -24.188 -34.321 -1.542  1.00 61.47  ? 721 THR   A O   1 
ATOM   2401 C CB  . THR   A 1 348 ? -26.271 -34.427 0.780   1.00 64.37  ? 721 THR   A CB  1 
ATOM   2402 O OG1 . THR   A 1 348 ? -27.316 -33.742 1.474   1.00 62.63  ? 721 THR   A OG1 1 
ATOM   2403 C CG2 . THR   A 1 348 ? -25.801 -35.590 1.638   1.00 63.60  ? 721 THR   A CG2 1 
ATOM   2404 N N   . ALA   A 1 349 ? -22.871 -34.317 0.287   1.00 61.28  ? 722 ALA   A N   1 
ATOM   2405 C CA  . ALA   A 1 349 ? -21.768 -35.037 -0.335  1.00 60.06  ? 722 ALA   A CA  1 
ATOM   2406 C C   . ALA   A 1 349 ? -20.921 -35.694 0.753   1.00 64.45  ? 722 ALA   A C   1 
ATOM   2407 O O   . ALA   A 1 349 ? -20.677 -35.092 1.805   1.00 58.34  ? 722 ALA   A O   1 
ATOM   2408 C CB  . ALA   A 1 349 ? -20.935 -34.105 -1.188  1.00 55.91  ? 722 ALA   A CB  1 
ATOM   2409 N N   . MET   A 1 350 ? -20.474 -36.930 0.479   1.00 64.74  ? 723 MET   A N   1 
ATOM   2410 C CA  . MET   A 1 350 ? -19.736 -37.724 1.449   1.00 70.04  ? 723 MET   A CA  1 
ATOM   2411 C C   . MET   A 1 350 ? -20.656 -38.023 2.635   1.00 66.35  ? 723 MET   A C   1 
ATOM   2412 O O   . MET   A 1 350 ? -20.219 -38.013 3.783   1.00 64.20  ? 723 MET   A O   1 
ATOM   2413 C CB  . MET   A 1 350 ? -18.476 -36.994 1.945   1.00 73.08  ? 723 MET   A CB  1 
ATOM   2414 C CG  . MET   A 1 350 ? -17.627 -36.332 0.865   1.00 76.55  ? 723 MET   A CG  1 
ATOM   2415 S SD  . MET   A 1 350 ? -16.603 -37.479 -0.075  1.00 82.74  ? 723 MET   A SD  1 
ATOM   2416 C CE  . MET   A 1 350 ? -15.884 -36.351 -1.277  1.00 90.50  ? 723 MET   A CE  1 
ATOM   2417 N N   . ASP   A 1 351 ? -21.943 -38.244 2.338   1.00 69.93  ? 724 ASP   A N   1 
ATOM   2418 C CA  . ASP   A 1 351 ? -22.961 -38.510 3.344   1.00 73.28  ? 724 ASP   A CA  1 
ATOM   2419 C C   . ASP   A 1 351 ? -22.916 -37.442 4.442   1.00 68.00  ? 724 ASP   A C   1 
ATOM   2420 O O   . ASP   A 1 351 ? -23.008 -37.763 5.624   1.00 72.82  ? 724 ASP   A O   1 
ATOM   2421 C CB  . ASP   A 1 351 ? -22.848 -39.940 3.863   1.00 74.89  ? 724 ASP   A CB  1 
ATOM   2422 N N   . CYS   A 1 352 ? -22.779 -36.172 4.043   1.00 60.43  ? 725 CYS   A N   1 
ATOM   2423 C CA  . CYS   A 1 352 ? -22.831 -35.057 4.975   1.00 55.85  ? 725 CYS   A CA  1 
ATOM   2424 C C   . CYS   A 1 352 ? -23.498 -33.838 4.336   1.00 44.24  ? 725 CYS   A C   1 
ATOM   2425 O O   . CYS   A 1 352 ? -23.121 -33.409 3.250   1.00 43.45  ? 725 CYS   A O   1 
ATOM   2426 C CB  . CYS   A 1 352 ? -21.433 -34.670 5.429   1.00 62.74  ? 725 CYS   A CB  1 
ATOM   2427 S SG  . CYS   A 1 352 ? -21.453 -33.390 6.706   1.00 66.24  ? 725 CYS   A SG  1 
ATOM   2428 N N   . GLY   A 1 353 ? -24.467 -33.257 5.043   1.00 43.20  ? 726 GLY   A N   1 
ATOM   2429 C CA  . GLY   A 1 353 ? -25.230 -32.129 4.533   1.00 43.90  ? 726 GLY   A CA  1 
ATOM   2430 C C   . GLY   A 1 353 ? -24.542 -30.791 4.809   1.00 43.01  ? 726 GLY   A C   1 
ATOM   2431 O O   . GLY   A 1 353 ? -24.003 -30.582 5.894   1.00 45.37  ? 726 GLY   A O   1 
ATOM   2432 N N   . THR   A 1 354 ? -24.570 -29.894 3.813   1.00 44.33  ? 727 THR   A N   1 
ATOM   2433 C CA  . THR   A 1 354 ? -24.127 -28.512 3.968   1.00 47.00  ? 727 THR   A CA  1 
ATOM   2434 C C   . THR   A 1 354 ? -25.285 -27.564 3.641   1.00 41.24  ? 727 THR   A C   1 
ATOM   2435 O O   . THR   A 1 354 ? -25.860 -27.601 2.549   1.00 39.04  ? 727 THR   A O   1 
ATOM   2436 C CB  . THR   A 1 354 ? -22.927 -28.248 3.059   1.00 51.21  ? 727 THR   A CB  1 
ATOM   2437 O OG1 . THR   A 1 354 ? -21.863 -29.085 3.509   1.00 50.89  ? 727 THR   A OG1 1 
ATOM   2438 C CG2 . THR   A 1 354 ? -22.480 -26.798 3.125   1.00 55.68  ? 727 THR   A CG2 1 
ATOM   2439 N N   . CYS   A 1 355 ? -25.655 -26.741 4.612   1.00 39.66  ? 728 CYS   A N   1 
ATOM   2440 C CA  . CYS   A 1 355 ? -26.685 -25.735 4.420   1.00 38.48  ? 728 CYS   A CA  1 
ATOM   2441 C C   . CYS   A 1 355 ? -26.024 -24.374 4.253   1.00 38.70  ? 728 CYS   A C   1 
ATOM   2442 O O   . CYS   A 1 355 ? -25.140 -24.029 5.037   1.00 42.13  ? 728 CYS   A O   1 
ATOM   2443 C CB  . CYS   A 1 355 ? -27.621 -25.661 5.617   1.00 41.85  ? 728 CYS   A CB  1 
ATOM   2444 S SG  . CYS   A 1 355 ? -28.603 -27.160 5.884   1.00 42.37  ? 728 CYS   A SG  1 
ATOM   2445 N N   . LEU   A 1 356 ? -26.444 -23.615 3.232   1.00 35.23  ? 729 LEU   A N   1 
ATOM   2446 C CA  . LEU   A 1 356 ? -26.018 -22.229 3.092   1.00 34.93  ? 729 LEU   A CA  1 
ATOM   2447 C C   . LEU   A 1 356 ? -27.198 -21.330 3.429   1.00 32.73  ? 729 LEU   A C   1 
ATOM   2448 O O   . LEU   A 1 356 ? -28.287 -21.504 2.887   1.00 33.46  ? 729 LEU   A O   1 
ATOM   2449 C CB  . LEU   A 1 356 ? -25.512 -21.866 1.698   1.00 35.53  ? 729 LEU   A CB  1 
ATOM   2450 C CG  . LEU   A 1 356 ? -24.422 -22.739 1.081   1.00 36.78  ? 729 LEU   A CG  1 
ATOM   2451 C CD1 . LEU   A 1 356 ? -24.071 -22.231 -0.304  1.00 38.33  ? 729 LEU   A CD1 1 
ATOM   2452 C CD2 . LEU   A 1 356 ? -23.192 -22.764 1.926   1.00 38.26  ? 729 LEU   A CD2 1 
ATOM   2453 N N   . THR   A 1 357 ? -26.960 -20.344 4.298   1.00 33.20  ? 730 THR   A N   1 
ATOM   2454 C CA  . THR   A 1 357 ? -27.910 -19.269 4.496   1.00 35.26  ? 730 THR   A CA  1 
ATOM   2455 C C   . THR   A 1 357 ? -27.210 -17.935 4.227   1.00 37.35  ? 730 THR   A C   1 
ATOM   2456 O O   . THR   A 1 357 ? -26.107 -17.703 4.731   1.00 37.09  ? 730 THR   A O   1 
ATOM   2457 C CB  . THR   A 1 357 ? -28.520 -19.405 5.889   1.00 33.68  ? 730 THR   A CB  1 
ATOM   2458 O OG1 . THR   A 1 357 ? -27.518 -19.310 6.896   1.00 34.38  ? 730 THR   A OG1 1 
ATOM   2459 C CG2 . THR   A 1 357 ? -29.243 -20.728 6.027   1.00 35.59  ? 730 THR   A CG2 1 
ATOM   2460 N N   . ALA   A 1 358 ? -27.839 -17.093 3.381   1.00 35.84  ? 731 ALA   A N   1 
ATOM   2461 C CA  . ALA   A 1 358 ? -27.225 -15.850 2.926   1.00 36.22  ? 731 ALA   A CA  1 
ATOM   2462 C C   . ALA   A 1 358 ? -28.107 -14.642 3.258   1.00 35.41  ? 731 ALA   A C   1 
ATOM   2463 O O   . ALA   A 1 358 ? -29.316 -14.665 3.037   1.00 33.30  ? 731 ALA   A O   1 
ATOM   2464 C CB  . ALA   A 1 358 ? -26.926 -15.950 1.449   1.00 37.23  ? 731 ALA   A CB  1 
ATOM   2465 N N   . SER   A 1 359 ? -27.491 -13.588 3.814   1.00 34.40  ? 732 SER   A N   1 
ATOM   2466 C CA  . SER   A 1 359 ? -28.240 -12.481 4.395   1.00 32.90  ? 732 SER   A CA  1 
ATOM   2467 C C   . SER   A 1 359 ? -27.873 -11.138 3.749   1.00 36.23  ? 732 SER   A C   1 
ATOM   2468 O O   . SER   A 1 359 ? -26.912 -11.037 2.967   1.00 36.00  ? 732 SER   A O   1 
ATOM   2469 C CB  . SER   A 1 359 ? -28.083 -12.475 5.895   1.00 34.97  ? 732 SER   A CB  1 
ATOM   2470 O OG  . SER   A 1 359 ? -26.721 -12.561 6.291   1.00 36.58  ? 732 SER   A OG  1 
ATOM   2471 N N   . MET   A 1 360 ? -28.646 -10.097 4.107   1.00 35.76  ? 733 MET   A N   1 
ATOM   2472 C CA  . MET   A 1 360 ? -28.626 -8.811  3.419   1.00 39.20  ? 733 MET   A CA  1 
ATOM   2473 C C   . MET   A 1 360 ? -27.368 -8.002  3.731   1.00 42.27  ? 733 MET   A C   1 
ATOM   2474 O O   . MET   A 1 360 ? -27.013 -7.110  2.966   1.00 45.26  ? 733 MET   A O   1 
ATOM   2475 C CB  . MET   A 1 360 ? -29.879 -7.997  3.747   1.00 40.34  ? 733 MET   A CB  1 
ATOM   2476 C CG  . MET   A 1 360 ? -31.122 -8.555  3.095   1.00 38.37  ? 733 MET   A CG  1 
ATOM   2477 S SD  . MET   A 1 360 ? -32.582 -7.579  3.477   1.00 40.53  ? 733 MET   A SD  1 
ATOM   2478 C CE  . MET   A 1 360 ? -32.299 -6.280  2.266   1.00 39.75  ? 733 MET   A CE  1 
ATOM   2479 N N   . ASP   A 1 361 ? -26.662 -8.381  4.799   1.00 45.17  ? 734 ASP   A N   1 
ATOM   2480 C CA  . ASP   A 1 361 ? -25.359 -7.831  5.145   1.00 41.93  ? 734 ASP   A CA  1 
ATOM   2481 C C   . ASP   A 1 361 ? -24.252 -8.494  4.334   1.00 43.53  ? 734 ASP   A C   1 
ATOM   2482 O O   . ASP   A 1 361 ? -23.077 -8.200  4.538   1.00 46.63  ? 734 ASP   A O   1 
ATOM   2483 C CB  . ASP   A 1 361 ? -25.071 -8.049  6.622   1.00 42.72  ? 734 ASP   A CB  1 
ATOM   2484 C CG  . ASP   A 1 361 ? -25.246 -9.491  7.096   1.00 47.94  ? 734 ASP   A CG  1 
ATOM   2485 O OD1 . ASP   A 1 361 ? -25.336 -10.409 6.214   1.00 42.54  ? 734 ASP   A OD1 1 
ATOM   2486 O OD2 . ASP   A 1 361 ? -25.348 -9.684  8.334   1.00 43.47  ? 734 ASP   A OD2 1 
ATOM   2487 N N   . GLY   A 1 362 ? -24.601 -9.447  3.469   1.00 42.87  ? 735 GLY   A N   1 
ATOM   2488 C CA  . GLY   A 1 362 ? -23.595 -10.087 2.634   1.00 42.29  ? 735 GLY   A CA  1 
ATOM   2489 C C   . GLY   A 1 362 ? -22.962 -11.334 3.270   1.00 39.26  ? 735 GLY   A C   1 
ATOM   2490 O O   . GLY   A 1 362 ? -22.180 -12.020 2.628   1.00 43.65  ? 735 GLY   A O   1 
ATOM   2491 N N   . LYS   A 1 363 ? -23.313 -11.654 4.510   1.00 39.56  ? 736 LYS   A N   1 
ATOM   2492 C CA  . LYS   A 1 363 ? -22.716 -12.795 5.191   1.00 44.16  ? 736 LYS   A CA  1 
ATOM   2493 C C   . LYS   A 1 363 ? -23.376 -14.101 4.751   1.00 40.79  ? 736 LYS   A C   1 
ATOM   2494 O O   . LYS   A 1 363 ? -24.595 -14.174 4.648   1.00 43.02  ? 736 LYS   A O   1 
ATOM   2495 C CB  . LYS   A 1 363 ? -22.916 -12.608 6.698   1.00 45.73  ? 736 LYS   A CB  1 
ATOM   2496 C CG  . LYS   A 1 363 ? -22.262 -11.346 7.259   1.00 54.17  ? 736 LYS   A CG  1 
ATOM   2497 C CD  . LYS   A 1 363 ? -20.940 -11.574 7.973   1.00 62.19  ? 736 LYS   A CD  1 
ATOM   2498 C CE  . LYS   A 1 363 ? -20.227 -10.329 8.433   1.00 66.75  ? 736 LYS   A CE  1 
ATOM   2499 N NZ  . LYS   A 1 363 ? -19.389 -9.793  7.355   1.00 69.34  ? 736 LYS   A NZ  1 
ATOM   2500 N N   . ILE   A 1 364 ? -22.565 -15.139 4.535   1.00 39.76  ? 737 ILE   A N   1 
ATOM   2501 C CA  . ILE   A 1 364 ? -23.086 -16.466 4.251   1.00 42.14  ? 737 ILE   A CA  1 
ATOM   2502 C C   . ILE   A 1 364 ? -22.658 -17.431 5.355   1.00 41.32  ? 737 ILE   A C   1 
ATOM   2503 O O   . ILE   A 1 364 ? -21.476 -17.717 5.507   1.00 38.10  ? 737 ILE   A O   1 
ATOM   2504 C CB  . ILE   A 1 364 ? -22.622 -16.937 2.866   1.00 41.25  ? 737 ILE   A CB  1 
ATOM   2505 C CG1 . ILE   A 1 364 ? -22.995 -15.911 1.767   1.00 38.58  ? 737 ILE   A CG1 1 
ATOM   2506 C CG2 . ILE   A 1 364 ? -23.168 -18.331 2.562   1.00 38.54  ? 737 ILE   A CG2 1 
ATOM   2507 C CD1 . ILE   A 1 364 ? -22.382 -16.212 0.418   1.00 36.42  ? 737 ILE   A CD1 1 
ATOM   2508 N N   . LYS   A 1 365 ? -23.638 -17.910 6.128   1.00 43.92  ? 738 LYS   A N   1 
ATOM   2509 C CA  . LYS   A 1 365 ? -23.407 -18.971 7.097   1.00 45.06  ? 738 LYS   A CA  1 
ATOM   2510 C C   . LYS   A 1 365 ? -23.460 -20.317 6.382   1.00 46.45  ? 738 LYS   A C   1 
ATOM   2511 O O   . LYS   A 1 365 ? -24.336 -20.563 5.545   1.00 44.39  ? 738 LYS   A O   1 
ATOM   2512 C CB  . LYS   A 1 365 ? -24.411 -18.967 8.253   1.00 46.25  ? 738 LYS   A CB  1 
ATOM   2513 C CG  . LYS   A 1 365 ? -24.239 -17.827 9.247   1.00 55.42  ? 738 LYS   A CG  1 
ATOM   2514 C CD  . LYS   A 1 365 ? -22.865 -17.826 9.906   1.00 59.22  ? 738 LYS   A CD  1 
ATOM   2515 C CE  . LYS   A 1 365 ? -22.874 -17.342 11.328  1.00 61.18  ? 738 LYS   A CE  1 
ATOM   2516 N NZ  . LYS   A 1 365 ? -22.828 -15.886 11.424  1.00 58.43  ? 738 LYS   A NZ  1 
ATOM   2517 N N   . LEU   A 1 366 ? -22.485 -21.164 6.724   1.00 48.10  ? 739 LEU   A N   1 
ATOM   2518 C CA  . LEU   A 1 366 ? -22.364 -22.506 6.195   1.00 45.98  ? 739 LEU   A CA  1 
ATOM   2519 C C   . LEU   A 1 366 ? -22.412 -23.486 7.364   1.00 49.98  ? 739 LEU   A C   1 
ATOM   2520 O O   . LEU   A 1 366 ? -21.490 -23.535 8.171   1.00 52.51  ? 739 LEU   A O   1 
ATOM   2521 C CB  . LEU   A 1 366 ? -21.064 -22.561 5.401   1.00 48.37  ? 739 LEU   A CB  1 
ATOM   2522 C CG  . LEU   A 1 366 ? -20.928 -23.781 4.491   1.00 52.69  ? 739 LEU   A CG  1 
ATOM   2523 C CD1 . LEU   A 1 366 ? -20.009 -23.529 3.323   1.00 51.72  ? 739 LEU   A CD1 1 
ATOM   2524 C CD2 . LEU   A 1 366 ? -20.454 -24.982 5.307   1.00 58.49  ? 739 LEU   A CD2 1 
ATOM   2525 N N   . THR   A 1 367 ? -23.530 -24.212 7.461   1.00 50.68  ? 740 THR   A N   1 
ATOM   2526 C CA  . THR   A 1 367 ? -23.831 -25.085 8.580   1.00 49.80  ? 740 THR   A CA  1 
ATOM   2527 C C   . THR   A 1 367 ? -23.712 -26.533 8.100   1.00 49.52  ? 740 THR   A C   1 
ATOM   2528 O O   . THR   A 1 367 ? -24.289 -26.889 7.074   1.00 46.75  ? 740 THR   A O   1 
ATOM   2529 C CB  . THR   A 1 367 ? -25.234 -24.772 9.110   1.00 48.51  ? 740 THR   A CB  1 
ATOM   2530 O OG1 . THR   A 1 367 ? -25.343 -23.396 9.463   1.00 48.44  ? 740 THR   A OG1 1 
ATOM   2531 C CG2 . THR   A 1 367 ? -25.566 -25.548 10.373  1.00 51.87  ? 740 THR   A CG2 1 
ATOM   2532 N N   . THR   A 1 368 ? -22.940 -27.356 8.829   1.00 49.14  ? 741 THR   A N   1 
ATOM   2533 C CA  . THR   A 1 368 ? -22.734 -28.760 8.480   1.00 50.20  ? 741 THR   A CA  1 
ATOM   2534 C C   . THR   A 1 368 ? -23.700 -29.622 9.292   1.00 45.92  ? 741 THR   A C   1 
ATOM   2535 O O   . THR   A 1 368 ? -23.722 -29.524 10.514  1.00 47.24  ? 741 THR   A O   1 
ATOM   2536 C CB  . THR   A 1 368 ? -21.282 -29.155 8.754   1.00 51.73  ? 741 THR   A CB  1 
ATOM   2537 O OG1 . THR   A 1 368 ? -20.444 -28.234 8.063   1.00 48.68  ? 741 THR   A OG1 1 
ATOM   2538 C CG2 . THR   A 1 368 ? -20.969 -30.557 8.269   1.00 50.75  ? 741 THR   A CG2 1 
ATOM   2539 N N   . LEU   A 1 369 ? -24.515 -30.430 8.606   1.00 45.64  ? 742 LEU   A N   1 
ATOM   2540 C CA  . LEU   A 1 369 ? -25.482 -31.318 9.242   1.00 48.79  ? 742 LEU   A CA  1 
ATOM   2541 C C   . LEU   A 1 369 ? -25.207 -32.779 8.873   1.00 55.46  ? 742 LEU   A C   1 
ATOM   2542 O O   . LEU   A 1 369 ? -25.105 -33.096 7.686   1.00 54.59  ? 742 LEU   A O   1 
ATOM   2543 C CB  . LEU   A 1 369 ? -26.893 -30.987 8.770   1.00 54.31  ? 742 LEU   A CB  1 
ATOM   2544 C CG  . LEU   A 1 369 ? -27.424 -29.578 9.017   1.00 53.96  ? 742 LEU   A CG  1 
ATOM   2545 C CD1 . LEU   A 1 369 ? -28.846 -29.612 8.522   1.00 52.71  ? 742 LEU   A CD1 1 
ATOM   2546 C CD2 . LEU   A 1 369 ? -27.358 -29.145 10.473  1.00 57.54  ? 742 LEU   A CD2 1 
ATOM   2547 N N   . LEU   A 1 370 ? -25.178 -33.668 9.886   1.00 58.48  ? 743 LEU   A N   1 
ATOM   2548 C CA  . LEU   A 1 370 ? -25.224 -35.115 9.690   1.00 57.78  ? 743 LEU   A CA  1 
ATOM   2549 C C   . LEU   A 1 370 ? -26.589 -35.643 10.145  1.00 58.39  ? 743 LEU   A C   1 
ATOM   2550 O O   . LEU   A 1 370 ? -27.119 -35.213 11.167  1.00 54.98  ? 743 LEU   A O   1 
ATOM   2551 C CB  . LEU   A 1 370 ? -24.082 -35.797 10.444  1.00 55.93  ? 743 LEU   A CB  1 
ATOM   2552 N N   . ALA   A 1 371 ? -27.142 -36.589 9.377   1.00 66.97  ? 744 ALA   A N   1 
ATOM   2553 C CA  . ALA   A 1 371 ? -28.475 -37.133 9.602   1.00 79.03  ? 744 ALA   A CA  1 
ATOM   2554 C C   . ALA   A 1 371 ? -28.441 -38.299 10.594  1.00 89.57  ? 744 ALA   A C   1 
ATOM   2555 O O   . ALA   A 1 371 ? -27.722 -39.272 10.377  1.00 88.01  ? 744 ALA   A O   1 
ATOM   2556 C CB  . ALA   A 1 371 ? -29.058 -37.580 8.277   1.00 81.58  ? 744 ALA   A CB  1 
ATOM   2557 N N   . HIS   A 1 372 ? -29.254 -38.198 11.660  1.00 101.31 ? 745 HIS   A N   1 
ATOM   2558 C CA  . HIS   A 1 372 ? -29.410 -39.249 12.658  1.00 103.68 ? 745 HIS   A CA  1 
ATOM   2559 C C   . HIS   A 1 372 ? -30.804 -39.876 12.523  1.00 99.45  ? 745 HIS   A C   1 
ATOM   2560 O O   . HIS   A 1 372 ? -30.916 -40.963 11.909  1.00 91.59  ? 745 HIS   A O   1 
ATOM   2561 C CB  . HIS   A 1 372 ? -29.196 -38.697 14.075  1.00 101.47 ? 745 HIS   A CB  1 
HETATM 2562 C C4  . A1BIW B 2 .   ? -21.055 -27.245 -21.271 1.00 49.55  ? 801 A1BIW A C4  1 
HETATM 2563 C C5  . A1BIW B 2 .   ? -21.469 -25.938 -21.521 1.00 46.71  ? 801 A1BIW A C5  1 
HETATM 2564 C C6  . A1BIW B 2 .   ? -22.424 -25.320 -20.730 1.00 46.68  ? 801 A1BIW A C6  1 
HETATM 2565 C C7  . A1BIW B 2 .   ? -22.984 -25.993 -19.664 1.00 48.28  ? 801 A1BIW A C7  1 
HETATM 2566 C C8  . A1BIW B 2 .   ? -22.597 -27.293 -19.383 1.00 51.28  ? 801 A1BIW A C8  1 
HETATM 2567 C C15 . A1BIW B 2 .   ? -18.570 -26.225 -23.243 1.00 55.58  ? 801 A1BIW A C15 1 
HETATM 2568 C C17 . A1BIW B 2 .   ? -19.051 -25.498 -25.583 1.00 62.18  ? 801 A1BIW A C17 1 
HETATM 2569 C C20 . A1BIW B 2 .   ? -17.386 -23.278 -25.359 1.00 63.59  ? 801 A1BIW A C20 1 
HETATM 2570 C C21 . A1BIW B 2 .   ? -17.519 -24.181 -24.279 1.00 56.74  ? 801 A1BIW A C21 1 
HETATM 2571 C C24 . A1BIW B 2 .   ? -17.218 -21.585 -27.425 1.00 69.38  ? 801 A1BIW A C24 1 
HETATM 2572 C C1  . A1BIW B 2 .   ? -20.400 -30.441 -22.145 1.00 56.59  ? 801 A1BIW A C1  1 
HETATM 2573 C C2  . A1BIW B 2 .   ? -20.603 -29.148 -22.933 1.00 51.22  ? 801 A1BIW A C2  1 
HETATM 2574 C C3  . A1BIW B 2 .   ? -20.071 -27.892 -22.239 1.00 49.38  ? 801 A1BIW A C3  1 
HETATM 2575 C C9  . A1BIW B 2 .   ? -21.636 -27.902 -20.181 1.00 48.95  ? 801 A1BIW A C9  1 
HETATM 2576 S S10 . A1BIW B 2 .   ? -21.005 -29.457 -19.650 1.00 54.48  ? 801 A1BIW A S10 1 
HETATM 2577 C C11 . A1BIW B 2 .   ? -21.327 -30.615 -20.959 1.00 53.18  ? 801 A1BIW A C11 1 
HETATM 2578 O O12 . A1BIW B 2 .   ? -19.586 -29.298 -19.526 1.00 50.61  ? 801 A1BIW A O12 1 
HETATM 2579 O O13 . A1BIW B 2 .   ? -21.741 -29.899 -18.493 1.00 50.29  ? 801 A1BIW A O13 1 
HETATM 2580 N N14 . A1BIW B 2 .   ? -19.692 -26.954 -23.288 1.00 52.60  ? 801 A1BIW A N14 1 
HETATM 2581 C C16 . A1BIW B 2 .   ? -18.345 -25.278 -24.388 1.00 57.82  ? 801 A1BIW A C16 1 
HETATM 2582 C C18 . A1BIW B 2 .   ? -18.937 -24.638 -26.635 1.00 65.13  ? 801 A1BIW A C18 1 
HETATM 2583 C C19 . A1BIW B 2 .   ? -18.101 -23.508 -26.548 1.00 67.41  ? 801 A1BIW A C19 1 
HETATM 2584 N N22 . A1BIW B 2 .   ? -16.581 -22.181 -25.219 1.00 75.71  ? 801 A1BIW A N22 1 
HETATM 2585 C C23 . A1BIW B 2 .   ? -16.508 -21.359 -26.245 1.00 74.19  ? 801 A1BIW A C23 1 
HETATM 2586 N N25 . A1BIW B 2 .   ? -18.016 -22.646 -27.606 1.00 68.78  ? 801 A1BIW A N25 1 
HETATM 2587 O O26 . A1BIW B 2 .   ? -17.154 -20.692 -28.393 1.00 74.67  ? 801 A1BIW A O26 1 
HETATM 2588 O O27 . A1BIW B 2 .   ? -17.763 -26.328 -22.327 1.00 53.94  ? 801 A1BIW A O27 1 
HETATM 2589 X UNK . UNX   C 3 .   ? -44.192 -12.339 2.654   1.00 43.76  ? 802 UNX   A UNK 1 
HETATM 2590 O O   . HOH   D 4 .   ? -37.143 -25.329 15.191  1.00 73.41  ? 901 HOH   A O   1 
HETATM 2591 O O   . HOH   D 4 .   ? -20.304 -9.317  4.411   1.00 56.18  ? 902 HOH   A O   1 
HETATM 2592 O O   . HOH   D 4 .   ? -40.422 -37.270 -13.496 1.00 46.29  ? 903 HOH   A O   1 
HETATM 2593 O O   . HOH   D 4 .   ? -30.403 -32.143 -23.117 1.00 57.59  ? 904 HOH   A O   1 
HETATM 2594 O O   . HOH   D 4 .   ? -21.789 -31.316 2.570   1.00 46.81  ? 905 HOH   A O   1 
HETATM 2595 O O   . HOH   D 4 .   ? -24.075 -30.819 -4.516  1.00 63.92  ? 906 HOH   A O   1 
HETATM 2596 O O   . HOH   D 4 .   ? -20.143 -28.773 5.665   1.00 48.82  ? 907 HOH   A O   1 
HETATM 2597 O O   . HOH   D 4 .   ? -10.849 -25.388 1.535   1.00 49.54  ? 908 HOH   A O   1 
HETATM 2598 O O   . HOH   D 4 .   ? -25.174 -30.389 -26.675 1.00 50.30  ? 909 HOH   A O   1 
HETATM 2599 O O   . HOH   D 4 .   ? -15.708 -24.482 6.600   1.00 45.01  ? 910 HOH   A O   1 
HETATM 2600 O O   . HOH   D 4 .   ? -40.573 -17.813 -25.001 1.00 43.73  ? 911 HOH   A O   1 
HETATM 2601 O O   . HOH   D 4 .   ? -29.215 -19.145 -3.678  1.00 33.94  ? 912 HOH   A O   1 
HETATM 2602 O O   . HOH   D 4 .   ? -20.302 -33.839 -10.572 1.00 53.01  ? 913 HOH   A O   1 
HETATM 2603 O O   . HOH   D 4 .   ? -47.502 -16.036 4.767   1.00 45.90  ? 914 HOH   A O   1 
HETATM 2604 O O   . HOH   D 4 .   ? -33.520 -32.321 -21.170 1.00 46.76  ? 915 HOH   A O   1 
HETATM 2605 O O   . HOH   D 4 .   ? -18.975 -7.388  -2.305  1.00 46.52  ? 916 HOH   A O   1 
HETATM 2606 O O   . HOH   D 4 .   ? -44.773 -11.391 -0.220  1.00 49.83  ? 917 HOH   A O   1 
HETATM 2607 O O   . HOH   D 4 .   ? -20.970 -28.075 -11.183 1.00 45.26  ? 918 HOH   A O   1 
HETATM 2608 O O   . HOH   D 4 .   ? -26.666 -26.635 -5.116  1.00 47.18  ? 919 HOH   A O   1 
HETATM 2609 O O   . HOH   D 4 .   ? -35.895 -13.502 6.046   1.00 37.48  ? 920 HOH   A O   1 
HETATM 2610 O O   . HOH   D 4 .   ? -25.748 -11.962 9.616   1.00 41.94  ? 921 HOH   A O   1 
HETATM 2611 O O   . HOH   D 4 .   ? -31.793 -13.169 -3.825  1.00 47.72  ? 922 HOH   A O   1 
HETATM 2612 O O   . HOH   D 4 .   ? -29.513 -21.653 -10.831 1.00 36.31  ? 923 HOH   A O   1 
HETATM 2613 O O   . HOH   D 4 .   ? -32.669 -19.891 12.130  1.00 43.10  ? 924 HOH   A O   1 
HETATM 2614 O O   . HOH   D 4 .   ? -42.216 -15.609 -24.783 1.00 41.71  ? 925 HOH   A O   1 
HETATM 2615 O O   . HOH   D 4 .   ? -30.323 -21.253 -8.094  1.00 42.08  ? 926 HOH   A O   1 
HETATM 2616 O O   . HOH   D 4 .   ? -39.999 -20.354 7.229   1.00 37.62  ? 927 HOH   A O   1 
HETATM 2617 O O   . HOH   D 4 .   ? -42.446 -11.432 -1.470  1.00 40.03  ? 928 HOH   A O   1 
HETATM 2618 O O   . HOH   D 4 .   ? -33.981 -13.659 -2.734  1.00 43.00  ? 929 HOH   A O   1 
HETATM 2619 O O   . HOH   D 4 .   ? -39.339 -17.934 8.128   1.00 35.43  ? 930 HOH   A O   1 
HETATM 2620 O O   . HOH   D 4 .   ? -20.146 -25.747 9.052   1.00 46.20  ? 931 HOH   A O   1 
HETATM 2621 O O   . HOH   D 4 .   ? -30.181 -30.020 -13.332 1.00 53.78  ? 932 HOH   A O   1 
HETATM 2622 O O   . HOH   D 4 .   ? -50.823 -13.730 -9.997  1.00 54.60  ? 933 HOH   A O   1 
HETATM 2623 O O   . HOH   D 4 .   ? -28.679 -20.095 9.206   1.00 40.55  ? 934 HOH   A O   1 
HETATM 2624 O O   . HOH   D 4 .   ? -44.449 -36.438 -3.732  1.00 35.68  ? 935 HOH   A O   1 
HETATM 2625 O O   . HOH   D 4 .   ? -49.477 -11.661 -3.472  1.00 53.72  ? 936 HOH   A O   1 
HETATM 2626 O O   . HOH   D 4 .   ? -50.547 -29.619 -10.595 1.00 37.02  ? 937 HOH   A O   1 
HETATM 2627 O O   . HOH   D 4 .   ? -32.540 -23.277 -12.193 1.00 35.70  ? 938 HOH   A O   1 
HETATM 2628 O O   . HOH   D 4 .   ? -40.921 -38.302 -16.300 1.00 55.94  ? 939 HOH   A O   1 
HETATM 2629 O O   . HOH   D 4 .   ? -27.052 -27.271 -11.872 1.00 50.48  ? 940 HOH   A O   1 
HETATM 2630 O O   . HOH   D 4 .   ? -53.773 -20.710 -2.507  1.00 45.34  ? 941 HOH   A O   1 
HETATM 2631 O O   . HOH   D 4 .   ? -36.176 -38.309 -13.375 1.00 44.25  ? 942 HOH   A O   1 
HETATM 2632 O O   . HOH   D 4 .   ? -37.964 -19.137 2.442   1.00 26.64  ? 943 HOH   A O   1 
HETATM 2633 O O   . HOH   D 4 .   ? -47.561 -21.666 -21.278 1.00 37.44  ? 944 HOH   A O   1 
HETATM 2634 O O   . HOH   D 4 .   ? -36.352 -29.926 -8.659  1.00 38.94  ? 945 HOH   A O   1 
HETATM 2635 O O   . HOH   D 4 .   ? -47.392 -9.504  -8.517  1.00 50.20  ? 946 HOH   A O   1 
HETATM 2636 O O   . HOH   D 4 .   ? -44.221 -16.500 3.360   1.00 47.49  ? 947 HOH   A O   1 
HETATM 2637 O O   . HOH   D 4 .   ? -39.080 -15.182 -19.212 1.00 38.44  ? 948 HOH   A O   1 
HETATM 2638 O O   . HOH   D 4 .   ? -39.824 -34.520 -1.477  1.00 57.66  ? 949 HOH   A O   1 
HETATM 2639 O O   . HOH   D 4 .   ? -36.734 -22.785 -8.137  1.00 33.61  ? 950 HOH   A O   1 
HETATM 2640 O O   . HOH   D 4 .   ? -35.093 -17.798 -9.011  1.00 43.76  ? 951 HOH   A O   1 
HETATM 2641 O O   . HOH   D 4 .   ? -36.875 -16.115 -6.118  1.00 52.73  ? 952 HOH   A O   1 
HETATM 2642 O O   . HOH   D 4 .   ? -44.305 -20.506 -15.776 1.00 34.19  ? 953 HOH   A O   1 
HETATM 2643 O O   . HOH   D 4 .   ? -25.181 -7.089  -10.679 1.00 58.57  ? 954 HOH   A O   1 
HETATM 2644 O O   . HOH   D 4 .   ? -33.459 -29.997 -22.226 1.00 42.18  ? 955 HOH   A O   1 
HETATM 2645 O O   . HOH   D 4 .   ? -33.790 -3.852  9.696   1.00 53.27  ? 956 HOH   A O   1 
HETATM 2646 O O   . HOH   D 4 .   ? -30.341 -18.999 -6.109  1.00 30.99  ? 957 HOH   A O   1 
HETATM 2647 O O   . HOH   D 4 .   ? -50.231 -22.778 7.197   1.00 47.30  ? 958 HOH   A O   1 
HETATM 2648 O O   . HOH   D 4 .   ? -32.659 -28.314 -12.332 1.00 38.02  ? 959 HOH   A O   1 
HETATM 2649 O O   . HOH   D 4 .   ? -26.431 -24.317 -9.756  1.00 30.94  ? 960 HOH   A O   1 
HETATM 2650 O O   . HOH   D 4 .   ? -31.474 -28.569 -2.256  1.00 42.86  ? 961 HOH   A O   1 
HETATM 2651 O O   . HOH   D 4 .   ? -51.519 -15.716 -16.857 1.00 47.17  ? 962 HOH   A O   1 
HETATM 2652 O O   . HOH   D 4 .   ? -17.942 -31.051 0.683   1.00 53.58  ? 963 HOH   A O   1 
HETATM 2653 O O   . HOH   D 4 .   ? -34.628 -30.421 -24.549 1.00 50.51  ? 964 HOH   A O   1 
HETATM 2654 O O   . HOH   D 4 .   ? -37.685 -7.943  6.238   1.00 48.73  ? 965 HOH   A O   1 
HETATM 2655 O O   . HOH   D 4 .   ? -52.748 -28.091 -17.669 1.00 42.98  ? 966 HOH   A O   1 
HETATM 2656 O O   . HOH   D 4 .   ? -35.656 -19.911 -7.380  1.00 38.53  ? 967 HOH   A O   1 
HETATM 2657 O O   . HOH   D 4 .   ? -14.554 -14.424 5.072   1.00 55.89  ? 968 HOH   A O   1 
HETATM 2658 O O   . HOH   D 4 .   ? -30.310 -34.552 -24.559 1.00 56.48  ? 969 HOH   A O   1 
HETATM 2659 O O   . HOH   D 4 .   ? -10.020 -26.128 -16.883 1.00 58.65  ? 970 HOH   A O   1 
HETATM 2660 O O   . HOH   D 4 .   ? -22.930 -13.632 -29.131 1.00 54.53  ? 971 HOH   A O   1 
HETATM 2661 O O   . HOH   D 4 .   ? -30.753 -34.450 -18.957 1.00 40.72  ? 972 HOH   A O   1 
HETATM 2662 O O   A HOH   D 4 .   ? -31.064 -19.596 -11.981 0.50 12.61  ? 973 HOH   A O   1 
HETATM 2663 O O   B HOH   D 4 .   ? -29.930 -18.143 -10.526 0.50 17.92  ? 973 HOH   A O   1 
HETATM 2664 O O   . HOH   D 4 .   ? -34.713 -21.302 -10.568 1.00 44.89  ? 974 HOH   A O   1 
HETATM 2665 O O   . HOH   D 4 .   ? -49.360 -16.813 3.452   1.00 49.10  ? 975 HOH   A O   1 
HETATM 2666 O O   . HOH   D 4 .   ? -29.158 -31.767 -0.277  1.00 43.32  ? 976 HOH   A O   1 
HETATM 2667 O O   . HOH   D 4 .   ? -37.715 -14.572 -8.260  1.00 43.37  ? 977 HOH   A O   1 
HETATM 2668 O O   . HOH   D 4 .   ? -40.811 -36.351 -21.158 1.00 64.91  ? 978 HOH   A O   1 
HETATM 2669 O O   . HOH   D 4 .   ? -33.729 -25.397 16.737  1.00 56.07  ? 979 HOH   A O   1 
HETATM 2670 O O   . HOH   D 4 .   ? -33.874 -24.571 -9.128  1.00 57.55  ? 980 HOH   A O   1 
HETATM 2671 O O   . HOH   D 4 .   ? -31.959 -32.408 -11.791 1.00 58.31  ? 981 HOH   A O   1 
HETATM 2672 O O   . HOH   D 4 .   ? -25.839 -26.897 -8.663  1.00 55.92  ? 982 HOH   A O   1 
HETATM 2673 O O   . HOH   D 4 .   ? -47.223 -22.939 -23.147 1.00 48.29  ? 983 HOH   A O   1 
HETATM 2674 O O   . HOH   D 4 .   ? -13.062 -22.500 7.837   1.00 55.19  ? 984 HOH   A O   1 
HETATM 2675 O O   . HOH   D 4 .   ? -45.910 -14.073 9.485   1.00 48.66  ? 985 HOH   A O   1 
HETATM 2676 O O   . HOH   D 4 .   ? -50.050 -12.408 -18.566 1.00 49.25  ? 986 HOH   A O   1 
HETATM 2677 O O   . HOH   D 4 .   ? -55.427 -22.820 -13.413 1.00 45.20  ? 987 HOH   A O   1 
HETATM 2678 O O   . HOH   D 4 .   ? -52.123 -28.762 3.968   1.00 60.53  ? 988 HOH   A O   1 
HETATM 2679 O O   . HOH   D 4 .   ? -55.144 -25.859 -14.792 1.00 47.89  ? 989 HOH   A O   1 
HETATM 2680 O O   . HOH   D 4 .   ? -19.083 -32.243 2.546   1.00 51.47  ? 990 HOH   A O   1 
HETATM 2681 O O   . HOH   D 4 .   ? -32.120 -22.565 -9.537  1.00 51.85  ? 991 HOH   A O   1 
HETATM 2682 O O   . HOH   D 4 .   ? -30.219 -34.728 -11.550 1.00 56.32  ? 992 HOH   A O   1 
HETATM 2683 O O   . HOH   D 4 .   ? -36.894 -10.957 6.608   1.00 47.62  ? 993 HOH   A O   1 
# 
