data_9EIU
# 
_entry.id   9EIU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EIU         pdb_00009eiu 10.2210/pdb9eiu/pdb 
WWPDB D_1000290364 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EIU 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              b.collins@imb.uq.edu.au 
_pdbx_contact_author.name_first         Brett 
_pdbx_contact_author.name_last          Collins 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6070-3774 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Collins, B.M.' 1 ? 
'Gao, Y.'       2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of the human Cavin1 HR1 domain bound to nanobody B7' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Collins, B.M.' 1 ? 
primary 'Gao, Y.'       2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Caveolae-associated protein 1' 12761.657 1 ? ? ? ? 
2 polymer man 'Nanobody B7'                   13520.991 1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Cavin-1,Polymerase I and transcript release factor' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSPGIQLIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATDDNTVSKLLEKVRK
VSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFK
;
;GSPGIQLIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATDDNTVSKLLEKVRK
VSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFK
;
A ? 
2 'polypeptide(L)' no no 
;QVQLQESGGGLVQAGGSLRLSCAVSGIRVNVNAMYWYRQAPGKQRELVAIITTFGSTNYADSAKGRFTISRDNTKNTVYL
QMDNLKPEDTAVYYCNAPQFTDRYWGQGTQVTVSSHHHHHH
;
;QVQLQESGGGLVQAGGSLRLSCAVSGIRVNVNAMYWYRQAPGKQRELVAIITTFGSTNYADSAKGRFTISRDNTKNTVYL
QMDNLKPEDTAVYYCNAPQFTDRYWGQGTQVTVSSHHHHHH
;
B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   PRO n 
1 4   GLY n 
1 5   ILE n 
1 6   GLN n 
1 7   LEU n 
1 8   ILE n 
1 9   LYS n 
1 10  SER n 
1 11  ASP n 
1 12  GLN n 
1 13  VAL n 
1 14  ASN n 
1 15  GLY n 
1 16  VAL n 
1 17  LEU n 
1 18  VAL n 
1 19  LEU n 
1 20  SER n 
1 21  LEU n 
1 22  LEU n 
1 23  ASP n 
1 24  LYS n 
1 25  ILE n 
1 26  ILE n 
1 27  GLY n 
1 28  ALA n 
1 29  VAL n 
1 30  ASP n 
1 31  GLN n 
1 32  ILE n 
1 33  GLN n 
1 34  LEU n 
1 35  THR n 
1 36  GLN n 
1 37  ALA n 
1 38  GLN n 
1 39  LEU n 
1 40  GLU n 
1 41  GLU n 
1 42  ARG n 
1 43  GLN n 
1 44  ALA n 
1 45  GLU n 
1 46  MET n 
1 47  GLU n 
1 48  GLY n 
1 49  ALA n 
1 50  VAL n 
1 51  GLN n 
1 52  SER n 
1 53  ILE n 
1 54  GLN n 
1 55  GLY n 
1 56  GLU n 
1 57  LEU n 
1 58  SER n 
1 59  LYS n 
1 60  LEU n 
1 61  GLY n 
1 62  LYS n 
1 63  ALA n 
1 64  HIS n 
1 65  ALA n 
1 66  THR n 
1 67  ASP n 
1 68  ASP n 
1 69  ASN n 
1 70  THR n 
1 71  VAL n 
1 72  SER n 
1 73  LYS n 
1 74  LEU n 
1 75  LEU n 
1 76  GLU n 
1 77  LYS n 
1 78  VAL n 
1 79  ARG n 
1 80  LYS n 
1 81  VAL n 
1 82  SER n 
1 83  VAL n 
1 84  ASN n 
1 85  VAL n 
1 86  LYS n 
1 87  THR n 
1 88  VAL n 
1 89  ARG n 
1 90  GLY n 
1 91  SER n 
1 92  LEU n 
1 93  GLU n 
1 94  ARG n 
1 95  GLN n 
1 96  ALA n 
1 97  GLY n 
1 98  GLN n 
1 99  ILE n 
1 100 LYS n 
1 101 LYS n 
1 102 LEU n 
1 103 GLU n 
1 104 VAL n 
1 105 ASN n 
1 106 GLU n 
1 107 ALA n 
1 108 GLU n 
1 109 LEU n 
1 110 LEU n 
1 111 ARG n 
1 112 ARG n 
1 113 ARG n 
1 114 ASN n 
1 115 PHE n 
1 116 LYS n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   GLN n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  LEU n 
2 12  VAL n 
2 13  GLN n 
2 14  ALA n 
2 15  GLY n 
2 16  GLY n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  ALA n 
2 24  VAL n 
2 25  SER n 
2 26  GLY n 
2 27  ILE n 
2 28  ARG n 
2 29  VAL n 
2 30  ASN n 
2 31  VAL n 
2 32  ASN n 
2 33  ALA n 
2 34  MET n 
2 35  TYR n 
2 36  TRP n 
2 37  TYR n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLN n 
2 45  ARG n 
2 46  GLU n 
2 47  LEU n 
2 48  VAL n 
2 49  ALA n 
2 50  ILE n 
2 51  ILE n 
2 52  THR n 
2 53  THR n 
2 54  PHE n 
2 55  GLY n 
2 56  SER n 
2 57  THR n 
2 58  ASN n 
2 59  TYR n 
2 60  ALA n 
2 61  ASP n 
2 62  SER n 
2 63  ALA n 
2 64  LYS n 
2 65  GLY n 
2 66  ARG n 
2 67  PHE n 
2 68  THR n 
2 69  ILE n 
2 70  SER n 
2 71  ARG n 
2 72  ASP n 
2 73  ASN n 
2 74  THR n 
2 75  LYS n 
2 76  ASN n 
2 77  THR n 
2 78  VAL n 
2 79  TYR n 
2 80  LEU n 
2 81  GLN n 
2 82  MET n 
2 83  ASP n 
2 84  ASN n 
2 85  LEU n 
2 86  LYS n 
2 87  PRO n 
2 88  GLU n 
2 89  ASP n 
2 90  THR n 
2 91  ALA n 
2 92  VAL n 
2 93  TYR n 
2 94  TYR n 
2 95  CYS n 
2 96  ASN n 
2 97  ALA n 
2 98  PRO n 
2 99  GLN n 
2 100 PHE n 
2 101 THR n 
2 102 ASP n 
2 103 ARG n 
2 104 TYR n 
2 105 TRP n 
2 106 GLY n 
2 107 GLN n 
2 108 GLY n 
2 109 THR n 
2 110 GLN n 
2 111 VAL n 
2 112 THR n 
2 113 VAL n 
2 114 SER n 
2 115 SER n 
2 116 HIS n 
2 117 HIS n 
2 118 HIS n 
2 119 HIS n 
2 120 HIS n 
2 121 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 116 human ? 'CAVIN1, PTRF, FKSG13' ? ? ? ? ? ? 'Homo sapiens'  9606  ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 121 ?     ? ?                      ? ? ? ? ? ? 'Vicugna pacos' 30538 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   39  ?   ?   ?   A . n 
A 1 2   SER 2   40  ?   ?   ?   A . n 
A 1 3   PRO 3   41  ?   ?   ?   A . n 
A 1 4   GLY 4   42  ?   ?   ?   A . n 
A 1 5   ILE 5   43  ?   ?   ?   A . n 
A 1 6   GLN 6   44  ?   ?   ?   A . n 
A 1 7   LEU 7   45  ?   ?   ?   A . n 
A 1 8   ILE 8   46  ?   ?   ?   A . n 
A 1 9   LYS 9   47  ?   ?   ?   A . n 
A 1 10  SER 10  48  ?   ?   ?   A . n 
A 1 11  ASP 11  49  ?   ?   ?   A . n 
A 1 12  GLN 12  50  ?   ?   ?   A . n 
A 1 13  VAL 13  51  ?   ?   ?   A . n 
A 1 14  ASN 14  52  ?   ?   ?   A . n 
A 1 15  GLY 15  53  ?   ?   ?   A . n 
A 1 16  VAL 16  54  ?   ?   ?   A . n 
A 1 17  LEU 17  55  ?   ?   ?   A . n 
A 1 18  VAL 18  56  ?   ?   ?   A . n 
A 1 19  LEU 19  57  57  LEU LEU A . n 
A 1 20  SER 20  58  58  SER SER A . n 
A 1 21  LEU 21  59  59  LEU LEU A . n 
A 1 22  LEU 22  60  60  LEU LEU A . n 
A 1 23  ASP 23  61  61  ASP ASP A . n 
A 1 24  LYS 24  62  62  LYS LYS A . n 
A 1 25  ILE 25  63  63  ILE ILE A . n 
A 1 26  ILE 26  64  64  ILE ILE A . n 
A 1 27  GLY 27  65  65  GLY GLY A . n 
A 1 28  ALA 28  66  66  ALA ALA A . n 
A 1 29  VAL 29  67  67  VAL VAL A . n 
A 1 30  ASP 30  68  68  ASP ASP A . n 
A 1 31  GLN 31  69  69  GLN GLN A . n 
A 1 32  ILE 32  70  70  ILE ILE A . n 
A 1 33  GLN 33  71  71  GLN GLN A . n 
A 1 34  LEU 34  72  72  LEU LEU A . n 
A 1 35  THR 35  73  73  THR THR A . n 
A 1 36  GLN 36  74  74  GLN GLN A . n 
A 1 37  ALA 37  75  75  ALA ALA A . n 
A 1 38  GLN 38  76  76  GLN GLN A . n 
A 1 39  LEU 39  77  77  LEU LEU A . n 
A 1 40  GLU 40  78  78  GLU GLU A . n 
A 1 41  GLU 41  79  79  GLU GLU A . n 
A 1 42  ARG 42  80  80  ARG ARG A . n 
A 1 43  GLN 43  81  81  GLN GLN A . n 
A 1 44  ALA 44  82  82  ALA ALA A . n 
A 1 45  GLU 45  83  83  GLU GLU A . n 
A 1 46  MET 46  84  84  MET MET A . n 
A 1 47  GLU 47  85  85  GLU GLU A . n 
A 1 48  GLY 48  86  86  GLY GLY A . n 
A 1 49  ALA 49  87  87  ALA ALA A . n 
A 1 50  VAL 50  88  88  VAL VAL A . n 
A 1 51  GLN 51  89  89  GLN GLN A . n 
A 1 52  SER 52  90  90  SER SER A . n 
A 1 53  ILE 53  91  91  ILE ILE A . n 
A 1 54  GLN 54  92  92  GLN GLN A . n 
A 1 55  GLY 55  93  93  GLY GLY A . n 
A 1 56  GLU 56  94  94  GLU GLU A . n 
A 1 57  LEU 57  95  95  LEU LEU A . n 
A 1 58  SER 58  96  96  SER SER A . n 
A 1 59  LYS 59  97  97  LYS LYS A . n 
A 1 60  LEU 60  98  98  LEU LEU A . n 
A 1 61  GLY 61  99  ?   ?   ?   A . n 
A 1 62  LYS 62  100 ?   ?   ?   A . n 
A 1 63  ALA 63  101 ?   ?   ?   A . n 
A 1 64  HIS 64  102 ?   ?   ?   A . n 
A 1 65  ALA 65  103 ?   ?   ?   A . n 
A 1 66  THR 66  104 ?   ?   ?   A . n 
A 1 67  ASP 67  105 ?   ?   ?   A . n 
A 1 68  ASP 68  106 ?   ?   ?   A . n 
A 1 69  ASN 69  107 ?   ?   ?   A . n 
A 1 70  THR 70  108 ?   ?   ?   A . n 
A 1 71  VAL 71  109 ?   ?   ?   A . n 
A 1 72  SER 72  110 ?   ?   ?   A . n 
A 1 73  LYS 73  111 ?   ?   ?   A . n 
A 1 74  LEU 74  112 ?   ?   ?   A . n 
A 1 75  LEU 75  113 ?   ?   ?   A . n 
A 1 76  GLU 76  114 ?   ?   ?   A . n 
A 1 77  LYS 77  115 ?   ?   ?   A . n 
A 1 78  VAL 78  116 ?   ?   ?   A . n 
A 1 79  ARG 79  117 ?   ?   ?   A . n 
A 1 80  LYS 80  118 ?   ?   ?   A . n 
A 1 81  VAL 81  119 ?   ?   ?   A . n 
A 1 82  SER 82  120 ?   ?   ?   A . n 
A 1 83  VAL 83  121 ?   ?   ?   A . n 
A 1 84  ASN 84  122 ?   ?   ?   A . n 
A 1 85  VAL 85  123 ?   ?   ?   A . n 
A 1 86  LYS 86  124 ?   ?   ?   A . n 
A 1 87  THR 87  125 ?   ?   ?   A . n 
A 1 88  VAL 88  126 ?   ?   ?   A . n 
A 1 89  ARG 89  127 ?   ?   ?   A . n 
A 1 90  GLY 90  128 ?   ?   ?   A . n 
A 1 91  SER 91  129 ?   ?   ?   A . n 
A 1 92  LEU 92  130 ?   ?   ?   A . n 
A 1 93  GLU 93  131 ?   ?   ?   A . n 
A 1 94  ARG 94  132 ?   ?   ?   A . n 
A 1 95  GLN 95  133 ?   ?   ?   A . n 
A 1 96  ALA 96  134 ?   ?   ?   A . n 
A 1 97  GLY 97  135 ?   ?   ?   A . n 
A 1 98  GLN 98  136 ?   ?   ?   A . n 
A 1 99  ILE 99  137 ?   ?   ?   A . n 
A 1 100 LYS 100 138 ?   ?   ?   A . n 
A 1 101 LYS 101 139 ?   ?   ?   A . n 
A 1 102 LEU 102 140 ?   ?   ?   A . n 
A 1 103 GLU 103 141 ?   ?   ?   A . n 
A 1 104 VAL 104 142 ?   ?   ?   A . n 
A 1 105 ASN 105 143 ?   ?   ?   A . n 
A 1 106 GLU 106 144 ?   ?   ?   A . n 
A 1 107 ALA 107 145 ?   ?   ?   A . n 
A 1 108 GLU 108 146 ?   ?   ?   A . n 
A 1 109 LEU 109 147 ?   ?   ?   A . n 
A 1 110 LEU 110 148 ?   ?   ?   A . n 
A 1 111 ARG 111 149 ?   ?   ?   A . n 
A 1 112 ARG 112 150 ?   ?   ?   A . n 
A 1 113 ARG 113 151 ?   ?   ?   A . n 
A 1 114 ASN 114 152 ?   ?   ?   A . n 
A 1 115 PHE 115 153 ?   ?   ?   A . n 
A 1 116 LYS 116 154 ?   ?   ?   A . n 
B 2 1   GLN 1   2   2   GLN GLN B . n 
B 2 2   VAL 2   3   3   VAL VAL B . n 
B 2 3   GLN 3   4   4   GLN GLN B . n 
B 2 4   LEU 4   5   5   LEU LEU B . n 
B 2 5   GLN 5   6   6   GLN GLN B . n 
B 2 6   GLU 6   7   7   GLU GLU B . n 
B 2 7   SER 7   8   8   SER SER B . n 
B 2 8   GLY 8   9   9   GLY GLY B . n 
B 2 9   GLY 9   10  10  GLY GLY B . n 
B 2 10  GLY 10  11  11  GLY GLY B . n 
B 2 11  LEU 11  12  12  LEU LEU B . n 
B 2 12  VAL 12  13  13  VAL VAL B . n 
B 2 13  GLN 13  14  14  GLN GLN B . n 
B 2 14  ALA 14  15  15  ALA ALA B . n 
B 2 15  GLY 15  16  16  GLY GLY B . n 
B 2 16  GLY 16  17  17  GLY GLY B . n 
B 2 17  SER 17  18  18  SER SER B . n 
B 2 18  LEU 18  19  19  LEU LEU B . n 
B 2 19  ARG 19  20  20  ARG ARG B . n 
B 2 20  LEU 20  21  21  LEU LEU B . n 
B 2 21  SER 21  22  22  SER SER B . n 
B 2 22  CYS 22  23  23  CYS CYS B . n 
B 2 23  ALA 23  24  24  ALA ALA B . n 
B 2 24  VAL 24  25  25  VAL VAL B . n 
B 2 25  SER 25  26  26  SER SER B . n 
B 2 26  GLY 26  27  27  GLY GLY B . n 
B 2 27  ILE 27  28  28  ILE ILE B . n 
B 2 28  ARG 28  29  29  ARG ARG B . n 
B 2 29  VAL 29  30  30  VAL VAL B . n 
B 2 30  ASN 30  31  31  ASN ASN B . n 
B 2 31  VAL 31  32  32  VAL VAL B . n 
B 2 32  ASN 32  33  33  ASN ASN B . n 
B 2 33  ALA 33  34  34  ALA ALA B . n 
B 2 34  MET 34  35  35  MET MET B . n 
B 2 35  TYR 35  36  36  TYR TYR B . n 
B 2 36  TRP 36  37  37  TRP TRP B . n 
B 2 37  TYR 37  38  38  TYR TYR B . n 
B 2 38  ARG 38  39  39  ARG ARG B . n 
B 2 39  GLN 39  40  40  GLN GLN B . n 
B 2 40  ALA 40  41  41  ALA ALA B . n 
B 2 41  PRO 41  42  42  PRO PRO B . n 
B 2 42  GLY 42  43  43  GLY GLY B . n 
B 2 43  LYS 43  44  44  LYS LYS B . n 
B 2 44  GLN 44  45  45  GLN GLN B . n 
B 2 45  ARG 45  46  46  ARG ARG B . n 
B 2 46  GLU 46  47  47  GLU GLU B . n 
B 2 47  LEU 47  48  48  LEU LEU B . n 
B 2 48  VAL 48  49  49  VAL VAL B . n 
B 2 49  ALA 49  50  50  ALA ALA B . n 
B 2 50  ILE 50  51  51  ILE ILE B . n 
B 2 51  ILE 51  52  52  ILE ILE B . n 
B 2 52  THR 52  53  53  THR THR B . n 
B 2 53  THR 53  54  54  THR THR B . n 
B 2 54  PHE 54  55  55  PHE PHE B . n 
B 2 55  GLY 55  56  56  GLY GLY B . n 
B 2 56  SER 56  57  57  SER SER B . n 
B 2 57  THR 57  58  58  THR THR B . n 
B 2 58  ASN 58  59  59  ASN ASN B . n 
B 2 59  TYR 59  60  60  TYR TYR B . n 
B 2 60  ALA 60  61  61  ALA ALA B . n 
B 2 61  ASP 61  62  62  ASP ASP B . n 
B 2 62  SER 62  63  63  SER SER B . n 
B 2 63  ALA 63  64  64  ALA ALA B . n 
B 2 64  LYS 64  65  65  LYS LYS B . n 
B 2 65  GLY 65  66  66  GLY GLY B . n 
B 2 66  ARG 66  67  67  ARG ARG B . n 
B 2 67  PHE 67  68  68  PHE PHE B . n 
B 2 68  THR 68  69  69  THR THR B . n 
B 2 69  ILE 69  70  70  ILE ILE B . n 
B 2 70  SER 70  71  71  SER SER B . n 
B 2 71  ARG 71  72  72  ARG ARG B . n 
B 2 72  ASP 72  73  73  ASP ASP B . n 
B 2 73  ASN 73  74  74  ASN ASN B . n 
B 2 74  THR 74  75  75  THR THR B . n 
B 2 75  LYS 75  76  76  LYS LYS B . n 
B 2 76  ASN 76  77  77  ASN ASN B . n 
B 2 77  THR 77  78  78  THR THR B . n 
B 2 78  VAL 78  79  79  VAL VAL B . n 
B 2 79  TYR 79  80  80  TYR TYR B . n 
B 2 80  LEU 80  81  81  LEU LEU B . n 
B 2 81  GLN 81  82  82  GLN GLN B . n 
B 2 82  MET 82  83  83  MET MET B . n 
B 2 83  ASP 83  84  84  ASP ASP B . n 
B 2 84  ASN 84  85  85  ASN ASN B . n 
B 2 85  LEU 85  86  86  LEU LEU B . n 
B 2 86  LYS 86  87  87  LYS LYS B . n 
B 2 87  PRO 87  88  88  PRO PRO B . n 
B 2 88  GLU 88  89  89  GLU GLU B . n 
B 2 89  ASP 89  90  90  ASP ASP B . n 
B 2 90  THR 90  91  91  THR THR B . n 
B 2 91  ALA 91  92  92  ALA ALA B . n 
B 2 92  VAL 92  93  93  VAL VAL B . n 
B 2 93  TYR 93  94  94  TYR TYR B . n 
B 2 94  TYR 94  95  95  TYR TYR B . n 
B 2 95  CYS 95  96  96  CYS CYS B . n 
B 2 96  ASN 96  97  97  ASN ASN B . n 
B 2 97  ALA 97  98  98  ALA ALA B . n 
B 2 98  PRO 98  99  99  PRO PRO B . n 
B 2 99  GLN 99  100 100 GLN GLN B . n 
B 2 100 PHE 100 101 101 PHE PHE B . n 
B 2 101 THR 101 102 102 THR THR B . n 
B 2 102 ASP 102 103 103 ASP ASP B . n 
B 2 103 ARG 103 104 104 ARG ARG B . n 
B 2 104 TYR 104 105 105 TYR TYR B . n 
B 2 105 TRP 105 106 106 TRP TRP B . n 
B 2 106 GLY 106 107 107 GLY GLY B . n 
B 2 107 GLN 107 108 108 GLN GLN B . n 
B 2 108 GLY 108 109 109 GLY GLY B . n 
B 2 109 THR 109 110 110 THR THR B . n 
B 2 110 GLN 110 111 111 GLN GLN B . n 
B 2 111 VAL 111 112 112 VAL VAL B . n 
B 2 112 THR 112 113 113 THR THR B . n 
B 2 113 VAL 113 114 114 VAL VAL B . n 
B 2 114 SER 114 115 115 SER SER B . n 
B 2 115 SER 115 116 116 SER SER B . n 
B 2 116 HIS 116 117 ?   ?   ?   B . n 
B 2 117 HIS 117 118 ?   ?   ?   B . n 
B 2 118 HIS 118 119 ?   ?   ?   B . n 
B 2 119 HIS 119 120 ?   ?   ?   B . n 
B 2 120 HIS 120 121 ?   ?   ?   B . n 
B 2 121 HIS 121 122 ?   ?   ?   B . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.21.2_5419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EIU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.669 
_cell.length_a_esd                 ? 
_cell.length_b                     58.669 
_cell.length_b_esd                 ? 
_cell.length_c                     61.293 
_cell.length_c_esd                 ? 
_cell.volume                       182708.555 
_cell.volume_esd                   ? 
_cell.Z_PDB                        3 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EIU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                143 
_symmetry.space_group_name_Hall            'P 3' 
_symmetry.space_group_name_H-M             'P 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EIU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.32 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.92 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M potassium thiocyanate, 20% PEG 3350 and 0.2 M potassium citrate, 20% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-01-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX2 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          94.34 
_reflns.entry_id                                       9EIU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              4.0 
_reflns.d_resolution_low                               30.65 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     1975 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.037 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    4.0 
_reflns_shell.d_res_low                                     4.5 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             572 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.077 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.990 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               183.05 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EIU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            4.00 
_refine.ls_d_res_low                             30.65 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     1975 
_refine.ls_number_reflns_R_free                  130 
_refine.ls_number_reflns_R_work                  1845 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.95 
_refine.ls_percent_reflns_R_free                 6.58 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2063 
_refine.ls_R_factor_R_free                       0.2635 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2025 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          2.06 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 31.1874 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.0000 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       4.00 
_refine_hist.d_res_low                        30.65 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               1211 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1211 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0041  ? 1226 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7862  ? 1657 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0485  ? 188  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0097  ? 217  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.5354 ? 452  ? f_dihedral_angle_d ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       4.00 
_refine_ls_shell.d_res_low                        30.65 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             130 
_refine_ls_shell.number_reflns_R_work             1845 
_refine_ls_shell.percent_reflns_obs               98.95 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.2025 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.2635 
# 
_struct.entry_id                     9EIU 
_struct.title                        'Crystal structure of the human Cavin1 HR1 TS/DD mutant domain bound to nanobody B7' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EIU 
_struct_keywords.text            'Caveolae, Cavin1, nanobody, PROTEIN TRANSPORT' 
_struct_keywords.pdbx_keywords   'PROTEIN TRANSPORT' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CAVN1_HUMAN Q6NZI2 ? 1 
;LIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVK
TVRGSLERQAGQIKKLEVNEAELLRRRNFK
;
43 
2 PDB 9EIU        9EIU   ? 2 ? 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9EIU A 7 ? 116 ? Q6NZI2 43 ? 152 ? 45 154 
2 2 9EIU B 1 ? 121 ? 9EIU   2  ? 122 ? 2  122 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EIU GLY A 1  ? UNP Q6NZI2 ?   ?   'expression tag'      39  1 
1 9EIU SER A 2  ? UNP Q6NZI2 ?   ?   'expression tag'      40  2 
1 9EIU PRO A 3  ? UNP Q6NZI2 ?   ?   'expression tag'      41  3 
1 9EIU GLY A 4  ? UNP Q6NZI2 ?   ?   'expression tag'      42  4 
1 9EIU ILE A 5  ? UNP Q6NZI2 ?   ?   'expression tag'      43  5 
1 9EIU GLN A 6  ? UNP Q6NZI2 ?   ?   'expression tag'      44  6 
1 9EIU ASP A 67 ? UNP Q6NZI2 THR 103 'engineered mutation' 105 7 
1 9EIU ASP A 68 ? UNP Q6NZI2 SER 104 'engineered mutation' 106 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   hexameric 
_pdbx_struct_assembly.oligomeric_count     6 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 10190 ? 
1 MORE         -62   ? 
1 'SSA (A^2)'  20450 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_555 -y,x-y,z  -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 0.8660254038  -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 3_555 -x+y,-x,z -0.5000000000 0.8660254038  0.0000000000 0.0000000000 -0.8660254038 -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 20 ? LYS A 59  ? SER A 58 LYS A 97  1 ? 40 
HELX_P HELX_P2 AA2 LYS B 86 ? THR B 90  ? LYS B 87 THR B 91  5 ? 5  
HELX_P HELX_P3 AA3 ALA B 97 ? THR B 101 ? ALA B 98 THR B 102 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN B 3   ? SER B 7   ? GLN B 4   SER B 8   
AA1 2 LEU B 18  ? SER B 25  ? LEU B 19  SER B 26  
AA1 3 THR B 77  ? MET B 82  ? THR B 78  MET B 83  
AA1 4 PHE B 67  ? ASP B 72  ? PHE B 68  ASP B 73  
AA2 1 GLY B 10  ? GLN B 13  ? GLY B 11  GLN B 14  
AA2 2 THR B 109 ? SER B 114 ? THR B 110 SER B 115 
AA2 3 ALA B 91  ? ASN B 96  ? ALA B 92  ASN B 97  
AA2 4 MET B 34  ? GLN B 39  ? MET B 35  GLN B 40  
AA2 5 GLU B 46  ? ILE B 51  ? GLU B 47  ILE B 52  
AA2 6 THR B 57  ? TYR B 59  ? THR B 58  TYR B 60  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER B 7   ? N SER B 8   O SER B 21  ? O SER B 22  
AA1 2 3 N LEU B 18  ? N LEU B 19  O MET B 82  ? O MET B 83  
AA1 3 4 O TYR B 79  ? O TYR B 80  N SER B 70  ? N SER B 71  
AA2 1 2 N GLY B 10  ? N GLY B 11  O THR B 112 ? O THR B 113 
AA2 2 3 O VAL B 111 ? O VAL B 112 N ALA B 91  ? N ALA B 92  
AA2 3 4 O ASN B 96  ? O ASN B 97  N TYR B 35  ? N TYR B 36  
AA2 4 5 N ARG B 38  ? N ARG B 39  O GLU B 46  ? O GLU B 47  
AA2 5 6 N ILE B 50  ? N ILE B 51  O ASN B 58  ? O ASN B 59  
# 
_pdbx_entry_details.entry_id                   9EIU 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    LYS 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     65 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             35.24 
_pdbx_validate_torsion.psi             61.16 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z     
2 -y,x-y,z  
3 -x+y,-x,z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 39  ? A GLY 1   
2  1 Y 1 A SER 40  ? A SER 2   
3  1 Y 1 A PRO 41  ? A PRO 3   
4  1 Y 1 A GLY 42  ? A GLY 4   
5  1 Y 1 A ILE 43  ? A ILE 5   
6  1 Y 1 A GLN 44  ? A GLN 6   
7  1 Y 1 A LEU 45  ? A LEU 7   
8  1 Y 1 A ILE 46  ? A ILE 8   
9  1 Y 1 A LYS 47  ? A LYS 9   
10 1 Y 1 A SER 48  ? A SER 10  
11 1 Y 1 A ASP 49  ? A ASP 11  
12 1 Y 1 A GLN 50  ? A GLN 12  
13 1 Y 1 A VAL 51  ? A VAL 13  
14 1 Y 1 A ASN 52  ? A ASN 14  
15 1 Y 1 A GLY 53  ? A GLY 15  
16 1 Y 1 A VAL 54  ? A VAL 16  
17 1 Y 1 A LEU 55  ? A LEU 17  
18 1 Y 1 A VAL 56  ? A VAL 18  
19 1 Y 1 A GLY 99  ? A GLY 61  
20 1 Y 1 A LYS 100 ? A LYS 62  
21 1 Y 1 A ALA 101 ? A ALA 63  
22 1 Y 1 A HIS 102 ? A HIS 64  
23 1 Y 1 A ALA 103 ? A ALA 65  
24 1 Y 1 A THR 104 ? A THR 66  
25 1 Y 1 A ASP 105 ? A ASP 67  
26 1 Y 1 A ASP 106 ? A ASP 68  
27 1 Y 1 A ASN 107 ? A ASN 69  
28 1 Y 1 A THR 108 ? A THR 70  
29 1 Y 1 A VAL 109 ? A VAL 71  
30 1 Y 1 A SER 110 ? A SER 72  
31 1 Y 1 A LYS 111 ? A LYS 73  
32 1 Y 1 A LEU 112 ? A LEU 74  
33 1 Y 1 A LEU 113 ? A LEU 75  
34 1 Y 1 A GLU 114 ? A GLU 76  
35 1 Y 1 A LYS 115 ? A LYS 77  
36 1 Y 1 A VAL 116 ? A VAL 78  
37 1 Y 1 A ARG 117 ? A ARG 79  
38 1 Y 1 A LYS 118 ? A LYS 80  
39 1 Y 1 A VAL 119 ? A VAL 81  
40 1 Y 1 A SER 120 ? A SER 82  
41 1 Y 1 A VAL 121 ? A VAL 83  
42 1 Y 1 A ASN 122 ? A ASN 84  
43 1 Y 1 A VAL 123 ? A VAL 85  
44 1 Y 1 A LYS 124 ? A LYS 86  
45 1 Y 1 A THR 125 ? A THR 87  
46 1 Y 1 A VAL 126 ? A VAL 88  
47 1 Y 1 A ARG 127 ? A ARG 89  
48 1 Y 1 A GLY 128 ? A GLY 90  
49 1 Y 1 A SER 129 ? A SER 91  
50 1 Y 1 A LEU 130 ? A LEU 92  
51 1 Y 1 A GLU 131 ? A GLU 93  
52 1 Y 1 A ARG 132 ? A ARG 94  
53 1 Y 1 A GLN 133 ? A GLN 95  
54 1 Y 1 A ALA 134 ? A ALA 96  
55 1 Y 1 A GLY 135 ? A GLY 97  
56 1 Y 1 A GLN 136 ? A GLN 98  
57 1 Y 1 A ILE 137 ? A ILE 99  
58 1 Y 1 A LYS 138 ? A LYS 100 
59 1 Y 1 A LYS 139 ? A LYS 101 
60 1 Y 1 A LEU 140 ? A LEU 102 
61 1 Y 1 A GLU 141 ? A GLU 103 
62 1 Y 1 A VAL 142 ? A VAL 104 
63 1 Y 1 A ASN 143 ? A ASN 105 
64 1 Y 1 A GLU 144 ? A GLU 106 
65 1 Y 1 A ALA 145 ? A ALA 107 
66 1 Y 1 A GLU 146 ? A GLU 108 
67 1 Y 1 A LEU 147 ? A LEU 109 
68 1 Y 1 A LEU 148 ? A LEU 110 
69 1 Y 1 A ARG 149 ? A ARG 111 
70 1 Y 1 A ARG 150 ? A ARG 112 
71 1 Y 1 A ARG 151 ? A ARG 113 
72 1 Y 1 A ASN 152 ? A ASN 114 
73 1 Y 1 A PHE 153 ? A PHE 115 
74 1 Y 1 A LYS 154 ? A LYS 116 
75 1 Y 1 B HIS 117 ? B HIS 116 
76 1 Y 1 B HIS 118 ? B HIS 117 
77 1 Y 1 B HIS 119 ? B HIS 118 
78 1 Y 1 B HIS 120 ? B HIS 119 
79 1 Y 1 B HIS 121 ? B HIS 120 
80 1 Y 1 B HIS 122 ? B HIS 121 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'National Health and Medical Research Council (NHMRC, Australia)' 
_pdbx_audit_support.country                Australia 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 3OGO ? 
2 ? 'experimental model' PDB 4QKV ? 
# 
_space_group.name_H-M_alt     'P 3' 
_space_group.name_Hall        'P 3' 
_space_group.IT_number        143 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9EIU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017045 
_atom_sites.fract_transf_matrix[1][2]   0.009841 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.019682 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016315 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.99627 ?       ? ? 14.84254 ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 6.96715 ?       ? ? 11.43723 ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N    . LEU A 1 19  ? 1.95100   13.81395  -8.03591 1.000 224.59959 ? 57  LEU A N    1 
ATOM 2    C CA   . LEU A 1 19  ? 1.88271   12.90525  -6.85850 1.000 261.14686 ? 57  LEU A CA   1 
ATOM 3    C C    . LEU A 1 19  ? 0.89925   11.76763  -7.13671 1.000 271.11070 ? 57  LEU A C    1 
ATOM 4    O O    . LEU A 1 19  ? -0.31498  11.97558  -7.18397 1.000 242.42219 ? 57  LEU A O    1 
ATOM 5    C CB   . LEU A 1 19  ? 1.47661   13.69935  -5.62460 1.000 234.63615 ? 57  LEU A CB   1 
ATOM 6    C CG   . LEU A 1 19  ? 1.55306   12.96190  -4.29984 1.000 254.36251 ? 57  LEU A CG   1 
ATOM 7    C CD1  . LEU A 1 19  ? 2.96746   13.03888  -3.73303 1.000 264.68231 ? 57  LEU A CD1  1 
ATOM 8    C CD2  . LEU A 1 19  ? 0.54777   13.57618  -3.36941 1.000 220.07641 ? 57  LEU A CD2  1 
ATOM 9    H H    . LEU A 1 19  ? 1.99099   13.33031  -8.78196 1.000 272.06511 ? 57  LEU A H    1 
ATOM 10   H HA   . LEU A 1 19  ? 2.74923   12.50857  -6.67773 1.000 315.92183 ? 57  LEU A HA   1 
ATOM 11   H HB2  . LEU A 1 19  ? 2.05998   14.47137  -5.55697 1.000 284.10899 ? 57  LEU A HB2  1 
ATOM 12   H HB3  . LEU A 1 19  ? 0.55748   13.98714  -5.73982 1.000 284.10899 ? 57  LEU A HB3  1 
ATOM 13   H HG   . LEU A 1 19  ? 1.34836   12.02001  -4.40864 1.000 307.78062 ? 57  LEU A HG   1 
ATOM 14   H HD11 . LEU A 1 19  ? 3.58455   12.64497  -4.36936 1.000 320.16438 ? 57  LEU A HD11 1 
ATOM 15   H HD12 . LEU A 1 19  ? 2.99912   12.55031  -2.89565 1.000 320.16438 ? 57  LEU A HD12 1 
ATOM 16   H HD13 . LEU A 1 19  ? 3.19699   13.96917  -3.58210 1.000 320.16438 ? 57  LEU A HD13 1 
ATOM 17   H HD21 . LEU A 1 19  ? 0.75827   14.51586  -3.25283 1.000 266.63730 ? 57  LEU A HD21 1 
ATOM 18   H HD22 . LEU A 1 19  ? 0.58837   13.11958  -2.51456 1.000 266.63730 ? 57  LEU A HD22 1 
ATOM 19   H HD23 . LEU A 1 19  ? -0.33775  13.48077  -3.75365 1.000 266.63730 ? 57  LEU A HD23 1 
ATOM 20   N N    . SER A 1 20  ? 1.43953   10.56596  -7.32116 1.000 285.20086 ? 58  SER A N    1 
ATOM 21   C CA   . SER A 1 20  ? 0.65184   9.41117   -7.71894 1.000 252.17005 ? 58  SER A CA   1 
ATOM 22   C C    . SER A 1 20  ? -0.02251  8.76002   -6.53085 1.000 237.94981 ? 58  SER A C    1 
ATOM 23   O O    . SER A 1 20  ? 0.26996   9.03789   -5.36571 1.000 230.99812 ? 58  SER A O    1 
ATOM 24   C CB   . SER A 1 20  ? 1.49115   8.34565   -8.43437 1.000 218.63752 ? 58  SER A CB   1 
ATOM 25   O OG   . SER A 1 20  ? 2.41706   7.71694   -7.57152 1.000 210.47107 ? 58  SER A OG   1 
ATOM 26   H H    . SER A 1 20  ? 2.27586   10.39317  -7.21967 1.000 344.78663 ? 58  SER A H    1 
ATOM 27   H HA   . SER A 1 20  ? -0.01980  9.74269   -8.33528 1.000 305.14966 ? 58  SER A HA   1 
ATOM 28   H HB2  . SER A 1 20  ? 0.89370   7.67014   -8.79164 1.000 264.91063 ? 58  SER A HB2  1 
ATOM 29   H HB3  . SER A 1 20  ? 1.98054   8.77082   -9.15591 1.000 264.91063 ? 58  SER A HB3  1 
ATOM 30   H HG   . SER A 1 20  ? 3.01702   7.33793   -8.02096 1.000 255.11089 ? 58  SER A HG   1 
ATOM 31   N N    . LEU A 1 21  ? -0.95197  7.87187   -6.86332 1.000 218.40981 ? 59  LEU A N    1 
ATOM 32   C CA   . LEU A 1 21  ? -1.53527  7.00792   -5.85632 1.000 213.69245 ? 59  LEU A CA   1 
ATOM 33   C C    . LEU A 1 21  ? -0.44845  6.19594   -5.16397 1.000 221.04752 ? 59  LEU A C    1 
ATOM 34   O O    . LEU A 1 21  ? -0.47644  6.02640   -3.94111 1.000 241.26051 ? 59  LEU A O    1 
ATOM 35   C CB   . LEU A 1 21  ? -2.57525  6.10216   -6.51286 1.000 213.73789 ? 59  LEU A CB   1 
ATOM 36   C CG   . LEU A 1 21  ? -3.26673  5.08708   -5.61401 1.000 217.38963 ? 59  LEU A CG   1 
ATOM 37   C CD1  . LEU A 1 21  ? -3.97367  5.80548   -4.48952 1.000 187.17470 ? 59  LEU A CD1  1 
ATOM 38   C CD2  . LEU A 1 21  ? -4.24382  4.26567   -6.42809 1.000 216.96208 ? 59  LEU A CD2  1 
ATOM 39   H H    . LEU A 1 21  ? -1.25763  7.75272   -7.65829 1.000 264.63737 ? 59  LEU A H    1 
ATOM 40   H HA   . LEU A 1 21  ? -1.98789  7.53602   -5.18020 1.000 258.97654 ? 59  LEU A HA   1 
ATOM 41   H HB2  . LEU A 1 21  ? -3.26857  6.66651   -6.88931 1.000 259.03107 ? 59  LEU A HB2  1 
ATOM 42   H HB3  . LEU A 1 21  ? -2.13459  5.60285   -7.21814 1.000 259.03107 ? 59  LEU A HB3  1 
ATOM 43   H HG   . LEU A 1 21  ? -2.61484  4.48264   -5.22596 1.000 263.41316 ? 59  LEU A HG   1 
ATOM 44   H HD11 . LEU A 1 21  ? -3.31222  6.22773   -3.91935 1.000 227.15524 ? 59  LEU A HD11 1 
ATOM 45   H HD12 . LEU A 1 21  ? -4.56355  6.47744   -4.86556 1.000 227.15524 ? 59  LEU A HD12 1 
ATOM 46   H HD13 . LEU A 1 21  ? -4.48877  5.16199   -3.97815 1.000 227.15524 ? 59  LEU A HD13 1 
ATOM 47   H HD21 . LEU A 1 21  ? -3.76363  3.82347   -7.14557 1.000 262.90010 ? 59  LEU A HD21 1 
ATOM 48   H HD22 . LEU A 1 21  ? -4.92083  4.85438   -6.79685 1.000 262.90010 ? 59  LEU A HD22 1 
ATOM 49   H HD23 . LEU A 1 21  ? -4.65845  3.60515   -5.85129 1.000 262.90010 ? 59  LEU A HD23 1 
ATOM 50   N N    . LEU A 1 22  ? 0.50625   5.66443   -5.93623 1.000 213.47783 ? 60  LEU A N    1 
ATOM 51   C CA   . LEU A 1 22  ? 1.61105   4.91523   -5.34079 1.000 196.10112 ? 60  LEU A CA   1 
ATOM 52   C C    . LEU A 1 22  ? 2.47241   5.76381   -4.40701 1.000 182.21765 ? 60  LEU A C    1 
ATOM 53   O O    . LEU A 1 22  ? 2.91127   5.27571   -3.36131 1.000 163.82083 ? 60  LEU A O    1 
ATOM 54   C CB   . LEU A 1 22  ? 2.47907   4.31080   -6.44720 1.000 189.77429 ? 60  LEU A CB   1 
ATOM 55   C CG   . LEU A 1 22  ? 1.80155   3.21069   -7.26375 1.000 189.09917 ? 60  LEU A CG   1 
ATOM 56   C CD1  . LEU A 1 22  ? 2.66769   2.77964   -8.43721 1.000 186.83128 ? 60  LEU A CD1  1 
ATOM 57   C CD2  . LEU A 1 22  ? 1.48149   2.02582   -6.36504 1.000 201.05920 ? 60  LEU A CD2  1 
ATOM 58   H H    . LEU A 1 22  ? 0.53531   5.72335   -6.79372 1.000 258.71900 ? 60  LEU A H    1 
ATOM 59   H HA   . LEU A 1 22  ? 1.22827   4.20217   -4.80607 1.000 237.86695 ? 60  LEU A HA   1 
ATOM 60   H HB2  . LEU A 1 22  ? 2.73046   5.01820   -7.06143 1.000 230.27475 ? 60  LEU A HB2  1 
ATOM 61   H HB3  . LEU A 1 22  ? 3.27182   3.92715   -6.04068 1.000 230.27475 ? 60  LEU A HB3  1 
ATOM 62   H HG   . LEU A 1 22  ? 0.97295   3.55493   -7.63230 1.000 229.46460 ? 60  LEU A HG   1 
ATOM 63   H HD11 . LEU A 1 22  ? 2.84602   3.55067   -8.99810 1.000 226.74313 ? 60  LEU A HD11 1 
ATOM 64   H HD12 . LEU A 1 22  ? 3.50119   2.41734   -8.09820 1.000 226.74313 ? 60  LEU A HD12 1 
ATOM 65   H HD13 . LEU A 1 22  ? 2.19542   2.10238   -8.94631 1.000 226.74313 ? 60  LEU A HD13 1 
ATOM 66   H HD21 . LEU A 1 22  ? 1.14698   1.29691   -6.91065 1.000 243.81664 ? 60  LEU A HD21 1 
ATOM 67   H HD22 . LEU A 1 22  ? 2.29006   1.75074   -5.90522 1.000 243.81664 ? 60  LEU A HD22 1 
ATOM 68   H HD23 . LEU A 1 22  ? 0.80810   2.29187   -5.71955 1.000 243.81664 ? 60  LEU A HD23 1 
ATOM 69   N N    . ASP A 1 23  ? 2.74468   7.02473   -4.75929 1.000 195.99842 ? 61  ASP A N    1 
ATOM 70   C CA   . ASP A 1 23  ? 3.47891   7.88715   -3.83316 1.000 224.53846 ? 61  ASP A CA   1 
ATOM 71   C C    . ASP A 1 23  ? 2.70789   8.09387   -2.53408 1.000 205.79988 ? 61  ASP A C    1 
ATOM 72   O O    . ASP A 1 23  ? 3.28923   8.06087   -1.44009 1.000 201.46487 ? 61  ASP A O    1 
ATOM 73   C CB   . ASP A 1 23  ? 3.80157   9.22648   -4.49900 1.000 244.15665 ? 61  ASP A CB   1 
ATOM 74   C CG   . ASP A 1 23  ? 4.64995   9.06637   -5.74837 1.000 226.61491 ? 61  ASP A CG   1 
ATOM 75   O OD1  . ASP A 1 23  ? 5.57389   8.22436   -5.73461 1.000 210.98076 ? 61  ASP A OD1  1 
ATOM 76   O OD2  . ASP A 1 23  ? 4.39972   9.78241   -6.74132 1.000 242.02191 ? 61  ASP A OD2  1 
ATOM 77   H H    . ASP A 1 23  ? 2.52241   7.39226   -5.50435 1.000 237.74371 ? 61  ASP A H    1 
ATOM 78   H HA   . ASP A 1 23  ? 4.32037   7.45894   -3.61070 1.000 271.99176 ? 61  ASP A HA   1 
ATOM 79   H HB2  . ASP A 1 23  ? 2.97280   9.66239   -4.75200 1.000 295.53359 ? 61  ASP A HB2  1 
ATOM 80   H HB3  . ASP A 1 23  ? 4.29085   9.78217   -3.87233 1.000 295.53359 ? 61  ASP A HB3  1 
ATOM 81   N N    . LYS A 1 24  ? 1.38445   8.23614   -2.63375 1.000 188.01148 ? 62  LYS A N    1 
ATOM 82   C CA   . LYS A 1 24  ? 0.55171   8.38090   -1.44440 1.000 205.43688 ? 62  LYS A CA   1 
ATOM 83   C C    . LYS A 1 24  ? 0.57623   7.11545   -0.59606 1.000 203.26721 ? 62  LYS A C    1 
ATOM 84   O O    . LYS A 1 24  ? 0.71517   7.17983   0.63102  1.000 200.06959 ? 62  LYS A O    1 
ATOM 85   C CB   . LYS A 1 24  ? -0.88072  8.73519   -1.85053 1.000 206.84513 ? 62  LYS A CB   1 
ATOM 86   C CG   . LYS A 1 24  ? -1.01784  10.06563  -2.58647 1.000 207.56524 ? 62  LYS A CG   1 
ATOM 87   C CD   . LYS A 1 24  ? -2.45298  10.31401  -3.02834 1.000 231.00930 ? 62  LYS A CD   1 
ATOM 88   C CE   . LYS A 1 24  ? -2.58633  11.62265  -3.79071 1.000 205.28643 ? 62  LYS A CE   1 
ATOM 89   N NZ   . LYS A 1 24  ? -3.93755  11.78304  -4.39476 1.000 176.66072 ? 62  LYS A NZ   1 
ATOM 90   H H    . LYS A 1 24  ? 0.94823   8.25180   -3.37474 1.000 228.15938 ? 62  LYS A H    1 
ATOM 91   H HA   . LYS A 1 24  ? 0.90044   9.10749   -0.90464 1.000 249.06986 ? 62  LYS A HA   1 
ATOM 92   H HB2  . LYS A 1 24  ? -1.21673  8.03960   -2.43718 1.000 250.75976 ? 62  LYS A HB2  1 
ATOM 93   H HB3  . LYS A 1 24  ? -1.42562  8.78559   -1.04964 1.000 250.75976 ? 62  LYS A HB3  1 
ATOM 94   H HG2  . LYS A 1 24  ? -0.75124  10.78800  -1.99655 1.000 251.62390 ? 62  LYS A HG2  1 
ATOM 95   H HG3  . LYS A 1 24  ? -0.45342  10.05603  -3.37530 1.000 251.62390 ? 62  LYS A HG3  1 
ATOM 96   H HD2  . LYS A 1 24  ? -2.73893  9.59244   -3.61012 1.000 279.75677 ? 62  LYS A HD2  1 
ATOM 97   H HD3  . LYS A 1 24  ? -3.02624  10.35724  -2.24706 1.000 279.75677 ? 62  LYS A HD3  1 
ATOM 98   H HE2  . LYS A 1 24  ? -2.43715  12.36300  -3.18200 1.000 248.88932 ? 62  LYS A HE2  1 
ATOM 99   H HE3  . LYS A 1 24  ? -1.93090  11.64358  -4.50546 1.000 248.88932 ? 62  LYS A HE3  1 
ATOM 100  H HZ1  . LYS A 1 24  ? -3.98279  12.55267  -4.83944 1.000 214.53847 ? 62  LYS A HZ1  1 
ATOM 101  H HZ2  . LYS A 1 24  ? -4.10041  11.11380  -4.95840 1.000 214.53847 ? 62  LYS A HZ2  1 
ATOM 102  H HZ3  . LYS A 1 24  ? -4.55829  11.78105  -3.75697 1.000 214.53847 ? 62  LYS A HZ3  1 
ATOM 103  N N    . ILE A 1 25  ? 0.43169   5.95525   -1.23698 1.000 212.42970 ? 63  ILE A N    1 
ATOM 104  C CA   . ILE A 1 25  ? 0.46449   4.68348   -0.51999 1.000 188.15434 ? 63  ILE A CA   1 
ATOM 105  C C    . ILE A 1 25  ? 1.80913   4.50242   0.17267  1.000 171.27544 ? 63  ILE A C    1 
ATOM 106  O O    . ILE A 1 25  ? 1.87871   4.07681   1.33186  1.000 169.44611 ? 63  ILE A O    1 
ATOM 107  C CB   . ILE A 1 25  ? 0.15889   3.52124   -1.48437 1.000 178.76283 ? 63  ILE A CB   1 
ATOM 108  C CG1  . ILE A 1 25  ? -1.29594  3.59846   -1.96048 1.000 185.15658 ? 63  ILE A CG1  1 
ATOM 109  C CG2  . ILE A 1 25  ? 0.42776   2.17556   -0.81453 1.000 181.26509 ? 63  ILE A CG2  1 
ATOM 110  C CD1  . ILE A 1 25  ? -1.62835  2.64751   -3.09434 1.000 155.65448 ? 63  ILE A CD1  1 
ATOM 111  H H    . ILE A 1 25  ? 0.31351   5.87763   -2.08528 1.000 257.46125 ? 63  ILE A H    1 
ATOM 112  H HA   . ILE A 1 25  ? -0.22236  4.69310   0.16489  1.000 228.33082 ? 63  ILE A HA   1 
ATOM 113  H HB   . ILE A 1 25  ? 0.74561   3.60231   -2.25254 1.000 217.06100 ? 63  ILE A HB   1 
ATOM 114  H HG12 . ILE A 1 25  ? -1.87834  3.38319   -1.21525 1.000 224.73350 ? 63  ILE A HG12 1 
ATOM 115  H HG13 . ILE A 1 25  ? -1.47364  4.50018   -2.27070 1.000 224.73350 ? 63  ILE A HG13 1 
ATOM 116  H HG21 . ILE A 1 25  ? 0.16836   1.46381   -1.42036 1.000 220.06371 ? 63  ILE A HG21 1 
ATOM 117  H HG22 . ILE A 1 25  ? -0.09187  2.12016   0.00267  1.000 220.06371 ? 63  ILE A HG22 1 
ATOM 118  H HG23 . ILE A 1 25  ? 1.37360   2.10783   -0.61033 1.000 220.06371 ? 63  ILE A HG23 1 
ATOM 119  H HD11 . ILE A 1 25  ? -2.52580  2.83513   -3.41103 1.000 189.33097 ? 63  ILE A HD11 1 
ATOM 120  H HD12 . ILE A 1 25  ? -1.57688  1.73578   -2.76722 1.000 189.33097 ? 63  ILE A HD12 1 
ATOM 121  H HD13 . ILE A 1 25  ? -0.99002  2.77760   -3.81303 1.000 189.33097 ? 63  ILE A HD13 1 
ATOM 122  N N    . ILE A 1 26  ? 2.89901   4.77789   -0.54497 1.000 175.37564 ? 64  ILE A N    1 
ATOM 123  C CA   . ILE A 1 26  ? 4.23066   4.63655   0.03273  1.000 168.07213 ? 64  ILE A CA   1 
ATOM 124  C C    . ILE A 1 26  ? 4.38548   5.53656   1.25216  1.000 167.97981 ? 64  ILE A C    1 
ATOM 125  O O    . ILE A 1 26  ? 4.89018   5.10495   2.29735  1.000 148.44018 ? 64  ILE A O    1 
ATOM 126  C CB   . ILE A 1 26  ? 5.29667   4.93547   -1.03890 1.000 157.87304 ? 64  ILE A CB   1 
ATOM 127  C CG1  . ILE A 1 26  ? 5.33459   3.80689   -2.07265 1.000 143.38848 ? 64  ILE A CG1  1 
ATOM 128  C CG2  . ILE A 1 26  ? 6.66674   5.12712   -0.40752 1.000 170.00685 ? 64  ILE A CG2  1 
ATOM 129  C CD1  . ILE A 1 26  ? 5.99974   4.19039   -3.37573 1.000 125.45641 ? 64  ILE A CD1  1 
ATOM 130  H H    . ILE A 1 26  ? 2.89306   5.04613   -1.36205 1.000 212.99637 ? 64  ILE A H    1 
ATOM 131  H HA   . ILE A 1 26  ? 4.34735   3.72171   0.33333  1.000 204.23216 ? 64  ILE A HA   1 
ATOM 132  H HB   . ILE A 1 26  ? 5.05361   5.76183   -1.48494 1.000 191.99325 ? 64  ILE A HB   1 
ATOM 133  H HG12 . ILE A 1 26  ? 5.82644   3.05900   -1.69896 1.000 174.61178 ? 64  ILE A HG12 1 
ATOM 134  H HG13 . ILE A 1 26  ? 4.42445   3.53822   -2.27357 1.000 174.61178 ? 64  ILE A HG13 1 
ATOM 135  H HG21 . ILE A 1 26  ? 7.32725   5.22774   -1.11072 1.000 206.55382 ? 64  ILE A HG21 1 
ATOM 136  H HG22 . ILE A 1 26  ? 6.65035   5.92270   0.14718  1.000 206.55382 ? 64  ILE A HG22 1 
ATOM 137  H HG23 . ILE A 1 26  ? 6.87620   4.35033   0.13436  1.000 206.55382 ? 64  ILE A HG23 1 
ATOM 138  H HD11 . ILE A 1 26  ? 5.89535   3.46351   -4.00949 1.000 153.09330 ? 64  ILE A HD11 1 
ATOM 139  H HD12 . ILE A 1 26  ? 5.57874   4.99321   -3.72090 1.000 153.09330 ? 64  ILE A HD12 1 
ATOM 140  H HD13 . ILE A 1 26  ? 6.94179   4.35468   -3.21306 1.000 153.09330 ? 64  ILE A HD13 1 
ATOM 141  N N    . GLY A 1 27  ? 3.94314   6.79344   1.15253  1.000 173.83509 ? 65  GLY A N    1 
ATOM 142  C CA   . GLY A 1 27  ? 4.08981   7.69367   2.28348  1.000 176.85490 ? 65  GLY A CA   1 
ATOM 143  C C    . GLY A 1 27  ? 3.20390   7.32960   3.45740  1.000 172.74760 ? 65  GLY A C    1 
ATOM 144  O O    . GLY A 1 27  ? 3.60698   7.48625   4.61510  1.000 158.01155 ? 65  GLY A O    1 
ATOM 145  H H    . GLY A 1 27  ? 3.56610   7.13479   0.45904  1.000 211.14771 ? 65  GLY A H    1 
ATOM 146  H HA2  . GLY A 1 27  ? 5.01181   7.67757   2.58438  1.000 214.77148 ? 65  GLY A HA2  1 
ATOM 147  H HA3  . GLY A 1 27  ? 3.86478   8.59461   2.00318  1.000 214.77148 ? 65  GLY A HA3  1 
ATOM 148  N N    . ALA A 1 28  ? 2.02363   6.77084   3.18309  1.000 172.24018 ? 66  ALA A N    1 
ATOM 149  C CA   . ALA A 1 28  ? 1.17173   6.26567   4.25450  1.000 175.25129 ? 66  ALA A CA   1 
ATOM 150  C C    . ALA A 1 28  ? 1.82441   5.08483   4.96201  1.000 164.14550 ? 66  ALA A C    1 
ATOM 151  O O    . ALA A 1 28  ? 1.84607   5.02233   6.19561  1.000 168.51773 ? 66  ALA A O    1 
ATOM 152  C CB   . ALA A 1 28  ? -0.19609  5.87080   3.69605  1.000 183.62924 ? 66  ALA A CB   1 
ATOM 153  H H    . ALA A 1 28  ? 1.69782   6.67392   2.39312  1.000 209.23382 ? 66  ALA A H    1 
ATOM 154  H HA   . ALA A 1 28  ? 1.03759   6.97154   4.90615  1.000 212.84715 ? 66  ALA A HA   1 
ATOM 155  H HB1  . ALA A 1 28  ? -0.59856  6.64392   3.27036  1.000 222.90069 ? 66  ALA A HB1  1 
ATOM 156  H HB2  . ALA A 1 28  ? -0.75823  5.56440   4.42476  1.000 222.90069 ? 66  ALA A HB2  1 
ATOM 157  H HB3  . ALA A 1 28  ? -0.07887  5.15947   3.04708  1.000 222.90069 ? 66  ALA A HB3  1 
ATOM 158  N N    . VAL A 1 29  ? 2.33822   4.12468   4.19235  1.000 138.45852 ? 67  VAL A N    1 
ATOM 159  C CA   . VAL A 1 29  ? 3.03185   2.97828   4.77454  1.000 132.66434 ? 67  VAL A CA   1 
ATOM 160  C C    . VAL A 1 29  ? 4.20458   3.44422   5.63182  1.000 154.73591 ? 67  VAL A C    1 
ATOM 161  O O    . VAL A 1 29  ? 4.44439   2.91433   6.72590  1.000 161.41767 ? 67  VAL A O    1 
ATOM 162  C CB   . VAL A 1 29  ? 3.48230   2.01653   3.65792  1.000 170.05673 ? 67  VAL A CB   1 
ATOM 163  C CG1  . VAL A 1 29  ? 4.51189   1.01595   4.17807  1.000 195.41263 ? 67  VAL A CG1  1 
ATOM 164  C CG2  . VAL A 1 29  ? 2.27751   1.30430   3.05351  1.000 166.63994 ? 67  VAL A CG2  1 
ATOM 165  H H    . VAL A 1 29  ? 2.29883   4.11344   3.33333  1.000 168.69582 ? 67  VAL A H    1 
ATOM 166  H HA   . VAL A 1 29  ? 2.41795   2.50027   5.35380  1.000 161.74282 ? 67  VAL A HA   1 
ATOM 167  H HB   . VAL A 1 29  ? 3.90993   2.53142   2.95583  1.000 206.61368 ? 67  VAL A HB   1 
ATOM 168  H HG11 . VAL A 1 29  ? 4.68762   0.35649   3.48877  1.000 237.04076 ? 67  VAL A HG11 1 
ATOM 169  H HG12 . VAL A 1 29  ? 4.15773   0.58095   4.96943  1.000 237.04076 ? 67  VAL A HG12 1 
ATOM 170  H HG13 . VAL A 1 29  ? 5.32911   1.48962   4.39872  1.000 237.04076 ? 67  VAL A HG13 1 
ATOM 171  H HG21 . VAL A 1 29  ? 2.57695   0.74355   2.32085  1.000 202.51354 ? 67  VAL A HG21 1 
ATOM 172  H HG22 . VAL A 1 29  ? 1.64952   1.96762   2.72711  1.000 202.51354 ? 67  VAL A HG22 1 
ATOM 173  H HG23 . VAL A 1 29  ? 1.85733   0.75911   3.73697  1.000 202.51354 ? 67  VAL A HG23 1 
ATOM 174  N N    . ASP A 1 30  ? 4.96336   4.42885   5.14162  1.000 141.78356 ? 68  ASP A N    1 
ATOM 175  C CA   . ASP A 1 30  ? 6.11028   4.93464   5.89245  1.000 149.11051 ? 68  ASP A CA   1 
ATOM 176  C C    . ASP A 1 30  ? 5.68210   5.58077   7.20410  1.000 146.52474 ? 68  ASP A C    1 
ATOM 177  O O    . ASP A 1 30  ? 6.26647   5.31813   8.26929  1.000 123.31478 ? 68  ASP A O    1 
ATOM 178  C CB   . ASP A 1 30  ? 6.85930   5.95025   5.03207  1.000 157.72469 ? 68  ASP A CB   1 
ATOM 179  C CG   . ASP A 1 30  ? 8.26907   6.17716   5.49985  1.000 165.17245 ? 68  ASP A CG   1 
ATOM 180  O OD1  . ASP A 1 30  ? 9.03763   5.20568   5.53002  1.000 209.87581 ? 68  ASP A OD1  1 
ATOM 181  O OD2  . ASP A 1 30  ? 8.60279   7.33001   5.84424  1.000 171.25690 ? 68  ASP A OD2  1 
ATOM 182  H H    . ASP A 1 30  ? 4.83561   4.81611   4.38445  1.000 172.68587 ? 68  ASP A H    1 
ATOM 183  H HA   . ASP A 1 30  ? 6.69842   4.19282   6.10387  1.000 181.47822 ? 68  ASP A HA   1 
ATOM 184  H HB2  . ASP A 1 30  ? 6.89445   5.62630   4.11844  1.000 191.81523 ? 68  ASP A HB2  1 
ATOM 185  H HB3  . ASP A 1 30  ? 6.39148   6.79933   5.06524  1.000 191.81523 ? 68  ASP A HB3  1 
ATOM 186  N N    . GLN A 1 31  ? 4.64037   6.41181   7.14586  1.000 149.49668 ? 69  GLN A N    1 
ATOM 187  C CA   . GLN A 1 31  ? 4.08281   6.99432   8.35804  1.000 159.57480 ? 69  GLN A CA   1 
ATOM 188  C C    . GLN A 1 31  ? 3.65992   5.91051   9.33944  1.000 140.11453 ? 69  GLN A C    1 
ATOM 189  O O    . GLN A 1 31  ? 3.96263   5.98796   10.53624 1.000 116.98718 ? 69  GLN A O    1 
ATOM 190  C CB   . GLN A 1 31  ? 2.89122   7.87325   7.97608  1.000 153.65264 ? 69  GLN A CB   1 
ATOM 191  C CG   . GLN A 1 31  ? 2.02431   8.35724   9.12142  1.000 168.88430 ? 69  GLN A CG   1 
ATOM 192  C CD   . GLN A 1 31  ? 0.88527   9.23220   8.62895  1.000 151.58186 ? 69  GLN A CD   1 
ATOM 193  O OE1  . GLN A 1 31  ? 0.08648   8.80518   7.79635  1.000 185.18960 ? 69  GLN A OE1  1 
ATOM 194  N NE2  . GLN A 1 31  ? 0.79619   10.44973  9.14283  1.000 146.43589 ? 69  GLN A NE2  1 
ATOM 195  H H    . GLN A 1 31  ? 4.24311   6.65097   6.42158  1.000 181.94162 ? 69  GLN A H    1 
ATOM 196  H HA   . GLN A 1 31  ? 4.74972   7.54476   8.79752  1.000 194.03537 ? 69  GLN A HA   1 
ATOM 197  H HB2  . GLN A 1 31  ? 3.22939   8.66031   7.52103  1.000 186.92877 ? 69  GLN A HB2  1 
ATOM 198  H HB3  . GLN A 1 31  ? 2.31943   7.36517   7.37957  1.000 186.92877 ? 69  GLN A HB3  1 
ATOM 199  H HG2  . GLN A 1 31  ? 1.64433   7.59237   9.58129  1.000 205.20676 ? 69  GLN A HG2  1 
ATOM 200  H HG3  . GLN A 1 31  ? 2.56548   8.87814   9.73517  1.000 205.20676 ? 69  GLN A HG3  1 
ATOM 201  H HE21 . GLN A 1 31  ? 1.36890   10.71237  9.72817  1.000 178.26868 ? 69  GLN A HE21 1 
ATOM 202  H HE22 . GLN A 1 31  ? 0.16565   10.97762  8.89114  1.000 178.26868 ? 69  GLN A HE22 1 
ATOM 203  N N    . ILE A 1 32  ? 2.98817   4.87381   8.83844  1.000 140.69967 ? 70  ILE A N    1 
ATOM 204  C CA   . ILE A 1 32  ? 2.47607   3.81590   9.70302  1.000 141.03778 ? 70  ILE A CA   1 
ATOM 205  C C    . ILE A 1 32  ? 3.61300   3.07076   10.38640 1.000 153.01962 ? 70  ILE A C    1 
ATOM 206  O O    . ILE A 1 32  ? 3.53330   2.74883   11.57511 1.000 177.62361 ? 70  ILE A O    1 
ATOM 207  C CB   . ILE A 1 32  ? 1.58787   2.86276   8.88241  1.000 152.37208 ? 70  ILE A CB   1 
ATOM 208  C CG1  . ILE A 1 32  ? 0.33859   3.60241   8.40056  1.000 198.13355 ? 70  ILE A CG1  1 
ATOM 209  C CG2  . ILE A 1 32  ? 1.20685   1.64118   9.69849  1.000 197.28220 ? 70  ILE A CG2  1 
ATOM 210  C CD1  . ILE A 1 32  ? -0.36539  2.92150   7.25532  1.000 195.97212 ? 70  ILE A CD1  1 
ATOM 211  H H    . ILE A 1 32  ? 2.81630   4.76030   8.00347  1.000 171.38521 ? 70  ILE A H    1 
ATOM 212  H HA   . ILE A 1 32  ? 1.93675   4.22098   10.40012 1.000 171.79094 ? 70  ILE A HA   1 
ATOM 213  H HB   . ILE A 1 32  ? 2.09157   2.56091   8.11036  1.000 185.39210 ? 70  ILE A HB   1 
ATOM 214  H HG12 . ILE A 1 32  ? -0.28900  3.66756   9.13730  1.000 240.30586 ? 70  ILE A HG12 1 
ATOM 215  H HG13 . ILE A 1 32  ? 0.59599   4.48956   8.10457  1.000 240.30586 ? 70  ILE A HG13 1 
ATOM 216  H HG21 . ILE A 1 32  ? 0.57200   1.10942   9.19341  1.000 239.28424 ? 70  ILE A HG21 1 
ATOM 217  H HG22 . ILE A 1 32  ? 2.00504   1.12034   9.87882  1.000 239.28424 ? 70  ILE A HG22 1 
ATOM 218  H HG23 . ILE A 1 32  ? 0.80566   1.93121   10.53265 1.000 239.28424 ? 70  ILE A HG23 1 
ATOM 219  H HD11 . ILE A 1 32  ? 0.27663   2.74540   6.54984  1.000 237.71214 ? 70  ILE A HD11 1 
ATOM 220  H HD12 . ILE A 1 32  ? -1.06786  3.50349   6.92557  1.000 237.71214 ? 70  ILE A HD12 1 
ATOM 221  H HD13 . ILE A 1 32  ? -0.74754  2.08753   7.57053  1.000 237.71214 ? 70  ILE A HD13 1 
ATOM 222  N N    . GLN A 1 33  ? 4.66382   2.73839   9.63836  1.000 148.92190 ? 71  GLN A N    1 
ATOM 223  C CA   . GLN A 1 33  ? 5.77062   1.98476   10.22218 1.000 153.44029 ? 71  GLN A CA   1 
ATOM 224  C C    . GLN A 1 33  ? 6.52443   2.80451   11.26781 1.000 143.85065 ? 71  GLN A C    1 
ATOM 225  O O    . GLN A 1 33  ? 6.86368   2.29383   12.35217 1.000 140.22255 ? 71  GLN A O    1 
ATOM 226  C CB   . GLN A 1 33  ? 6.69862   1.51186   9.10525  1.000 154.40679 ? 71  GLN A CB   1 
ATOM 227  C CG   . GLN A 1 33  ? 6.06844   0.39625   8.28170  1.000 148.83341 ? 71  GLN A CG   1 
ATOM 228  C CD   . GLN A 1 33  ? 6.99108   -0.17164  7.22715  1.000 161.97817 ? 71  GLN A CD   1 
ATOM 229  O OE1  . GLN A 1 33  ? 7.76112   0.55402   6.59988  1.000 154.47348 ? 71  GLN A OE1  1 
ATOM 230  N NE2  . GLN A 1 33  ? 6.90643   -1.48041  7.01544  1.000 174.38364 ? 71  GLN A NE2  1 
ATOM 231  H H    . GLN A 1 33  ? 4.75927   2.93305   8.80614  1.000 181.25188 ? 71  GLN A H    1 
ATOM 232  H HA   . GLN A 1 33  ? 5.42292   1.20266   10.67862 1.000 186.67395 ? 71  GLN A HA   1 
ATOM 233  H HB2  . GLN A 1 33  ? 6.89112   2.25586   8.51338  1.000 187.83375 ? 71  GLN A HB2  1 
ATOM 234  H HB3  . GLN A 1 33  ? 7.52127   1.17588   9.49418  1.000 187.83375 ? 71  GLN A HB3  1 
ATOM 235  H HG2  . GLN A 1 33  ? 5.81651   -0.32763  8.87619  1.000 181.14570 ? 71  GLN A HG2  1 
ATOM 236  H HG3  . GLN A 1 33  ? 5.28290   0.74474   7.83184  1.000 181.14570 ? 71  GLN A HG3  1 
ATOM 237  H HE21 . GLN A 1 33  ? 6.34885   -1.95397  7.46761  1.000 211.80597 ? 71  GLN A HE21 1 
ATOM 238  H HE22 . GLN A 1 33  ? 7.40921   -1.85410  6.42623  1.000 211.80597 ? 71  GLN A HE22 1 
ATOM 239  N N    . LEU A 1 34  ? 6.72535   4.09918   10.99426 1.000 134.74198 ? 72  LEU A N    1 
ATOM 240  C CA   . LEU A 1 34  ? 7.34687   4.96981   11.98733 1.000 146.63589 ? 72  LEU A CA   1 
ATOM 241  C C    . LEU A 1 34  ? 6.49186   5.04517   13.25025 1.000 143.69825 ? 72  LEU A C    1 
ATOM 242  O O    . LEU A 1 34  ? 6.99906   4.92009   14.38150 1.000 138.87617 ? 72  LEU A O    1 
ATOM 243  C CB   . LEU A 1 34  ? 7.52943   6.36174   11.37770 1.000 102.30388 ? 72  LEU A CB   1 
ATOM 244  C CG   . LEU A 1 34  ? 8.56071   6.50340   10.24766 1.000 102.30388 ? 72  LEU A CG   1 
ATOM 245  C CD1  . LEU A 1 34  ? 8.45216   7.87783   9.60073  1.000 195.71117 ? 72  LEU A CD1  1 
ATOM 246  C CD2  . LEU A 1 34  ? 9.96664   6.26574   10.71594 1.000 102.30388 ? 72  LEU A CD2  1 
ATOM 247  H H    . LEU A 1 34  ? 6.51435   4.48684   10.25615 1.000 164.23598 ? 72  LEU A H    1 
ATOM 248  H HA   . LEU A 1 34  ? 8.21741   4.62131   12.23556 1.000 178.50867 ? 72  LEU A HA   1 
ATOM 249  H HB2  . LEU A 1 34  ? 6.67438   6.64289   11.01613 1.000 125.31025 ? 72  LEU A HB2  1 
ATOM 250  H HB3  . LEU A 1 34  ? 7.80379   6.96379   12.08705 1.000 125.31025 ? 72  LEU A HB3  1 
ATOM 251  H HG   . LEU A 1 34  ? 8.36419   5.82093   9.58696  1.000 125.31025 ? 72  LEU A HG   1 
ATOM 252  H HD11 . LEU A 1 34  ? 9.12104   7.95177   8.90214  1.000 237.39901 ? 72  LEU A HD11 1 
ATOM 253  H HD12 . LEU A 1 34  ? 7.56515   7.97919   9.22146  1.000 237.39901 ? 72  LEU A HD12 1 
ATOM 254  H HD13 . LEU A 1 34  ? 8.60276   8.55756   10.27615 1.000 237.39901 ? 72  LEU A HD13 1 
ATOM 255  H HD21 . LEU A 1 34  ? 10.04265  5.35355   11.03693 1.000 125.31025 ? 72  LEU A HD21 1 
ATOM 256  H HD22 . LEU A 1 34  ? 10.57487  6.40695   9.97363  1.000 125.31025 ? 72  LEU A HD22 1 
ATOM 257  H HD23 . LEU A 1 34  ? 10.16993  6.88670   11.43286 1.000 125.31025 ? 72  LEU A HD23 1 
ATOM 258  N N    . THR A 1 35  ? 5.17515   5.17532   13.07024 1.000 119.62818 ? 73  THR A N    1 
ATOM 259  C CA   . THR A 1 35  ? 4.27845   5.25783   14.21421 1.000 147.46395 ? 73  THR A CA   1 
ATOM 260  C C    . THR A 1 35  ? 4.26841   3.95352   15.00028 1.000 145.24349 ? 73  THR A C    1 
ATOM 261  O O    . THR A 1 35  ? 4.18192   3.97404   16.22987 1.000 158.17622 ? 73  THR A O    1 
ATOM 262  C CB   . THR A 1 35  ? 2.86513   5.61591   13.74535 1.000 146.07848 ? 73  THR A CB   1 
ATOM 263  O OG1  . THR A 1 35  ? 2.88275   6.88101   13.07134 1.000 205.42719 ? 73  THR A OG1  1 
ATOM 264  C CG2  . THR A 1 35  ? 1.91001   5.70492   14.91892 1.000 177.48208 ? 73  THR A CG2  1 
ATOM 265  H H    . THR A 1 35  ? 4.78442   5.21739   12.30529 1.000 146.09942 ? 73  THR A H    1 
ATOM 266  H HA   . THR A 1 35  ? 4.58659   5.96230   14.80554 1.000 179.50235 ? 73  THR A HA   1 
ATOM 267  H HB   . THR A 1 35  ? 2.55121   4.92412   13.14220 1.000 177.83978 ? 73  THR A HB   1 
ATOM 268  H HG1  . THR A 1 35  ? 3.17920   6.78673   12.29107 1.000 249.05823 ? 73  THR A HG1  1 
ATOM 269  H HG21 . THR A 1 35  ? 1.03726   5.99938   14.61477 1.000 215.52409 ? 73  THR A HG21 1 
ATOM 270  H HG22 . THR A 1 35  ? 1.81989   4.83574   15.33999 1.000 215.52409 ? 73  THR A HG22 1 
ATOM 271  H HG23 . THR A 1 35  ? 2.24571   6.33809   15.57259 1.000 215.52409 ? 73  THR A HG23 1 
ATOM 272  N N    . GLN A 1 36  ? 4.29597   2.80911   14.31156 1.000 141.53733 ? 74  GLN A N    1 
ATOM 273  C CA   . GLN A 1 36  ? 4.31335   1.53034   15.01700 1.000 166.83684 ? 74  GLN A CA   1 
ATOM 274  C C    . GLN A 1 36  ? 5.55776   1.37855   15.87619 1.000 154.42683 ? 74  GLN A C    1 
ATOM 275  O O    . GLN A 1 36  ? 5.48362   0.88652   17.01109 1.000 175.14333 ? 74  GLN A O    1 
ATOM 276  C CB   . GLN A 1 36  ? 4.24116   0.36590   14.03318 1.000 197.71053 ? 74  GLN A CB   1 
ATOM 277  C CG   . GLN A 1 36  ? 2.86020   0.05226   13.55122 1.000 214.06822 ? 74  GLN A CG   1 
ATOM 278  C CD   . GLN A 1 36  ? 2.79894   -1.26492  12.82122 1.000 205.51141 ? 74  GLN A CD   1 
ATOM 279  O OE1  . GLN A 1 36  ? 3.78138   -1.71594  12.23091 1.000 189.37936 ? 74  GLN A OE1  1 
ATOM 280  N NE2  . GLN A 1 36  ? 1.65315   -1.91876  12.90377 1.000 238.17735 ? 74  GLN A NE2  1 
ATOM 281  H H    . GLN A 1 36  ? 4.30491   2.74846   13.45375 1.000 172.39040 ? 74  GLN A H    1 
ATOM 282  H HA   . GLN A 1 36  ? 3.52999   1.50386   15.58845 1.000 202.74981 ? 74  GLN A HA   1 
ATOM 283  H HB2  . GLN A 1 36  ? 4.78123   0.58226   13.25703 1.000 239.79823 ? 74  GLN A HB2  1 
ATOM 284  H HB3  . GLN A 1 36  ? 4.58827   -0.42877  14.46782 1.000 239.79823 ? 74  GLN A HB3  1 
ATOM 285  H HG2  . GLN A 1 36  ? 2.26047   0.00467   14.31211 1.000 259.42747 ? 74  GLN A HG2  1 
ATOM 286  H HG3  . GLN A 1 36  ? 2.56931   0.74931   12.94260 1.000 259.42747 ? 74  GLN A HG3  1 
ATOM 287  H HE21 . GLN A 1 36  ? 1.00015   -1.58685  13.35435 1.000 288.35842 ? 74  GLN A HE21 1 
ATOM 288  H HE22 . GLN A 1 36  ? 1.56067   -2.67608  12.50689 1.000 288.35842 ? 74  GLN A HE22 1 
ATOM 289  N N    . ALA A 1 37  ? 6.70977   1.82416   15.36917 1.000 141.35863 ? 75  ALA A N    1 
ATOM 290  C CA   . ALA A 1 37  ? 7.91479   1.74069   16.18999 1.000 158.08446 ? 75  ALA A CA   1 
ATOM 291  C C    . ALA A 1 37  ? 7.80914   2.64360   17.41454 1.000 170.68674 ? 75  ALA A C    1 
ATOM 292  O O    . ALA A 1 37  ? 8.21520   2.25641   18.52448 1.000 190.54767 ? 75  ALA A O    1 
ATOM 293  C CB   . ALA A 1 37  ? 9.14559   2.09359   15.35671 1.000 183.91895 ? 75  ALA A CB   1 
ATOM 294  H H    . ALA A 1 37  ? 6.81471   2.16438   14.58634 1.000 172.17596 ? 75  ALA A H    1 
ATOM 295  H HA   . ALA A 1 37  ? 8.02134   0.82782   16.50020 1.000 192.24696 ? 75  ALA A HA   1 
ATOM 296  H HB1  . ALA A 1 37  ? 9.22096   1.46418   14.62251 1.000 223.24834 ? 75  ALA A HB1  1 
ATOM 297  H HB2  . ALA A 1 37  ? 9.93376   2.04105   15.91967 1.000 223.24834 ? 75  ALA A HB2  1 
ATOM 298  H HB3  . ALA A 1 37  ? 9.04535   2.99440   15.01119 1.000 223.24834 ? 75  ALA A HB3  1 
ATOM 299  N N    . GLN A 1 38  ? 7.18421   3.81393   17.25533 1.000 139.34155 ? 76  GLN A N    1 
ATOM 300  C CA   . GLN A 1 38  ? 7.03077   4.70176   18.40741 1.000 149.89976 ? 76  GLN A CA   1 
ATOM 301  C C    . GLN A 1 38  ? 6.02831   4.15208   19.42400 1.000 149.33767 ? 76  GLN A C    1 
ATOM 302  O O    . GLN A 1 38  ? 6.25622   4.23643   20.64080 1.000 165.35197 ? 76  GLN A O    1 
ATOM 303  C CB   . GLN A 1 38  ? 6.61937   6.09523   17.93947 1.000 142.04860 ? 76  GLN A CB   1 
ATOM 304  C CG   . GLN A 1 38  ? 7.77011   6.88098   17.33800 1.000 146.32184 ? 76  GLN A CG   1 
ATOM 305  C CD   . GLN A 1 38  ? 7.31096   8.05616   16.49963 1.000 155.74337 ? 76  GLN A CD   1 
ATOM 306  O OE1  . GLN A 1 38  ? 6.14597   8.45024   16.54209 1.000 166.71836 ? 76  GLN A OE1  1 
ATOM 307  N NE2  . GLN A 1 38  ? 8.23177   8.62554   15.73050 1.000 202.75377 ? 76  GLN A NE2  1 
ATOM 308  H H    . GLN A 1 38  ? 6.85240   4.10612   16.51768 1.000 169.75546 ? 76  GLN A H    1 
ATOM 309  H HA   . GLN A 1 38  ? 7.88771   4.77330   18.85623 1.000 182.42532 ? 76  GLN A HA   1 
ATOM 310  H HB2  . GLN A 1 38  ? 5.92934   6.00941   17.26317 1.000 173.00393 ? 76  GLN A HB2  1 
ATOM 311  H HB3  . GLN A 1 38  ? 6.27977   6.59483   18.69840 1.000 173.00393 ? 76  GLN A HB3  1 
ATOM 312  H HG2  . GLN A 1 38  ? 8.32586   7.22446   18.05498 1.000 178.13181 ? 76  GLN A HG2  1 
ATOM 313  H HG3  . GLN A 1 38  ? 8.28974   6.29245   16.76833 1.000 178.13181 ? 76  GLN A HG3  1 
ATOM 314  H HE21 . GLN A 1 38  ? 9.03687   8.32321   15.72810 1.000 245.85013 ? 76  GLN A HE21 1 
ATOM 315  H HE22 . GLN A 1 38  ? 8.02296   9.29659   15.23483 1.000 245.85013 ? 76  GLN A HE22 1 
ATOM 316  N N    . LEU A 1 39  ? 4.91814   3.58208   18.94992 1.000 145.87859 ? 77  LEU A N    1 
ATOM 317  C CA   . LEU A 1 39  ? 3.95279   2.96739   19.85807 1.000 159.93448 ? 77  LEU A CA   1 
ATOM 318  C C    . LEU A 1 39  ? 4.55962   1.79042   20.61628 1.000 154.82134 ? 77  LEU A C    1 
ATOM 319  O O    . LEU A 1 39  ? 4.29981   1.61686   21.81425 1.000 177.34635 ? 77  LEU A O    1 
ATOM 320  C CB   . LEU A 1 39  ? 2.71572   2.50268   19.08153 1.000 140.70884 ? 77  LEU A CB   1 
ATOM 321  C CG   . LEU A 1 39  ? 1.89392   3.52656   18.29212 1.000 161.67687 ? 77  LEU A CG   1 
ATOM 322  C CD1  . LEU A 1 39  ? 0.80699   2.82105   17.49412 1.000 138.15787 ? 77  LEU A CD1  1 
ATOM 323  C CD2  . LEU A 1 39  ? 1.28551   4.57647   19.20230 1.000 200.22636 ? 77  LEU A CD2  1 
ATOM 324  H H    . LEU A 1 39  ? 4.70387   3.53879   18.11816 1.000 177.59991 ? 77  LEU A H    1 
ATOM 325  H HA   . LEU A 1 39  ? 3.67970   3.63706   20.50449 1.000 194.46698 ? 77  LEU A HA   1 
ATOM 326  H HB2  . LEU A 1 39  ? 3.01044   1.83737   18.44012 1.000 171.39621 ? 77  LEU A HB2  1 
ATOM 327  H HB3  . LEU A 1 39  ? 2.10753   2.10032   19.72114 1.000 171.39621 ? 77  LEU A HB3  1 
ATOM 328  H HG   . LEU A 1 39  ? 2.48560   3.98738   17.67693 1.000 196.55785 ? 77  LEU A HG   1 
ATOM 329  H HD11 . LEU A 1 39  ? 0.28039   3.48500   17.02213 1.000 168.33505 ? 77  LEU A HD11 1 
ATOM 330  H HD12 . LEU A 1 39  ? 1.22296   2.21667   16.85962 1.000 168.33505 ? 77  LEU A HD12 1 
ATOM 331  H HD13 . LEU A 1 39  ? 0.24095   2.32228   18.10381 1.000 168.33505 ? 77  LEU A HD13 1 
ATOM 332  H HD21 . LEU A 1 39  ? 0.82676   5.23702   18.65998 1.000 242.81724 ? 77  LEU A HD21 1 
ATOM 333  H HD22 . LEU A 1 39  ? 0.65656   4.14729   19.80323 1.000 242.81724 ? 77  LEU A HD22 1 
ATOM 334  H HD23 . LEU A 1 39  ? 1.99323   5.00083   19.71216 1.000 242.81724 ? 77  LEU A HD23 1 
ATOM 335  N N    . GLU A 1 40  ? 5.38571   0.97922   19.94845 1.000 151.05016 ? 78  GLU A N    1 
ATOM 336  C CA   . GLU A 1 40  ? 6.07772   -0.09733  20.65459 1.000 159.23727 ? 78  GLU A CA   1 
ATOM 337  C C    . GLU A 1 40  ? 7.00505   0.44259   21.73914 1.000 175.03194 ? 78  GLU A C    1 
ATOM 338  O O    . GLU A 1 40  ? 7.06034   -0.10538  22.84806 1.000 189.94663 ? 78  GLU A O    1 
ATOM 339  C CB   . GLU A 1 40  ? 6.85852   -0.98373  19.68682 1.000 185.52243 ? 78  GLU A CB   1 
ATOM 340  C CG   . GLU A 1 40  ? 7.69374   -2.01365  20.43786 1.000 228.88715 ? 78  GLU A CG   1 
ATOM 341  C CD   . GLU A 1 40  ? 8.41117   -2.98654  19.53930 1.000 239.15102 ? 78  GLU A CD   1 
ATOM 342  O OE1  . GLU A 1 40  ? 7.95324   -3.20868  18.39940 1.000 275.01799 ? 78  GLU A OE1  1 
ATOM 343  O OE2  . GLU A 1 40  ? 9.42450   -3.55033  19.99691 1.000 217.25008 ? 78  GLU A OE2  1 
ATOM 344  H H    . GLU A 1 40  ? 5.55751   1.03080   19.10736 1.000 183.80580 ? 78  GLU A H    1 
ATOM 345  H HA   . GLU A 1 40  ? 5.39933   -0.64692  21.07723 1.000 193.63032 ? 78  GLU A HA   1 
ATOM 346  H HB2  . GLU A 1 40  ? 6.23769   -1.45407  19.10868 1.000 225.17252 ? 78  GLU A HB2  1 
ATOM 347  H HB3  . GLU A 1 40  ? 7.45461   -0.43313  19.15539 1.000 225.17252 ? 78  GLU A HB3  1 
ATOM 348  H HG2  . GLU A 1 40  ? 8.36293   -1.54888  20.96424 1.000 277.21018 ? 78  GLU A HG2  1 
ATOM 349  H HG3  . GLU A 1 40  ? 7.10975   -2.52450  21.02000 1.000 277.21018 ? 78  GLU A HG3  1 
ATOM 350  N N    . GLU A 1 41  ? 7.80026   1.46928   21.41857 1.000 148.50030 ? 79  GLU A N    1 
ATOM 351  C CA   . GLU A 1 41  ? 8.68801   2.02993   22.43833 1.000 164.16267 ? 79  GLU A CA   1 
ATOM 352  C C    . GLU A 1 41  ? 7.89541   2.54008   23.64260 1.000 184.04308 ? 79  GLU A C    1 
ATOM 353  O O    . GLU A 1 41  ? 8.28672   2.31597   24.79998 1.000 180.42103 ? 79  GLU A O    1 
ATOM 354  C CB   . GLU A 1 41  ? 9.55423   3.13751   21.83836 1.000 200.59583 ? 79  GLU A CB   1 
ATOM 355  C CG   . GLU A 1 41  ? 10.43780  3.85047   22.85504 1.000 221.20541 ? 79  GLU A CG   1 
ATOM 356  C CD   . GLU A 1 41  ? 11.66559  4.47550   22.22210 1.000 208.85174 ? 79  GLU A CD   1 
ATOM 357  O OE1  . GLU A 1 41  ? 11.50638  5.29227   21.29337 1.000 171.40350 ? 79  GLU A OE1  1 
ATOM 358  O OE2  . GLU A 1 41  ? 12.79007  4.14468   22.65029 1.000 192.94491 ? 79  GLU A OE2  1 
ATOM 359  H H    . GLU A 1 41  ? 7.84267   1.84505   20.64617 1.000 180.74597 ? 79  GLU A H    1 
ATOM 360  H HA   . GLU A 1 41  ? 9.28468   1.33225   22.75158 1.000 199.54081 ? 79  GLU A HA   1 
ATOM 361  H HB2  . GLU A 1 41  ? 10.13370  2.74875   21.16457 1.000 243.26060 ? 79  GLU A HB2  1 
ATOM 362  H HB3  . GLU A 1 41  ? 8.97418   3.80153   21.43400 1.000 243.26060 ? 79  GLU A HB3  1 
ATOM 363  H HG2  . GLU A 1 41  ? 9.92590   4.55655   23.27967 1.000 267.99210 ? 79  GLU A HG2  1 
ATOM 364  H HG3  . GLU A 1 41  ? 10.73529  3.21031   23.52032 1.000 267.99210 ? 79  GLU A HG3  1 
ATOM 365  N N    . ARG A 1 42  ? 6.77934   3.23069   23.39149 1.000 181.51985 ? 80  ARG A N    1 
ATOM 366  C CA   . ARG A 1 42  ? 5.92446   3.67793   24.49089 1.000 201.38898 ? 80  ARG A CA   1 
ATOM 367  C C    . ARG A 1 42  ? 5.41127   2.49768   25.31517 1.000 156.01816 ? 80  ARG A C    1 
ATOM 368  O O    . ARG A 1 42  ? 5.38490   2.55514   26.55571 1.000 163.31100 ? 80  ARG A O    1 
ATOM 369  C CB   . ARG A 1 42  ? 4.75330   4.49564   23.93929 1.000 203.39679 ? 80  ARG A CB   1 
ATOM 370  C CG   . ARG A 1 42  ? 5.16412   5.85104   23.38653 1.000 201.07678 ? 80  ARG A CG   1 
ATOM 371  C CD   . ARG A 1 42  ? 4.03892   6.55542   22.63443 1.000 209.19423 ? 80  ARG A CD   1 
ATOM 372  N NE   . ARG A 1 42  ? 2.90575   6.90993   23.48225 1.000 260.17578 ? 80  ARG A NE   1 
ATOM 373  C CZ   . ARG A 1 42  ? 1.69880   7.22005   23.02569 1.000 246.78998 ? 80  ARG A CZ   1 
ATOM 374  N NH1  . ARG A 1 42  ? 1.41274   7.16861   21.73444 1.000 224.87430 ? 80  ARG A NH1  1 
ATOM 375  N NH2  . ARG A 1 42  ? 0.74933   7.57552   23.88725 1.000 217.38500 ? 80  ARG A NH2  1 
ATOM 376  H H    . ARG A 1 42  ? 6.50026   3.44899   22.60787 1.000 220.36942 ? 80  ARG A H    1 
ATOM 377  H HA   . ARG A 1 42  ? 6.44456   4.24793   25.07868 1.000 244.21237 ? 80  ARG A HA   1 
ATOM 378  H HB2  . ARG A 1 42  ? 4.33486   3.99644   23.22054 1.000 246.62175 ? 80  ARG A HB2  1 
ATOM 379  H HB3  . ARG A 1 42  ? 4.11461   4.64753   24.65336 1.000 246.62175 ? 80  ARG A HB3  1 
ATOM 380  H HG2  . ARG A 1 42  ? 5.43485   6.42266   24.12196 1.000 243.83774 ? 80  ARG A HG2  1 
ATOM 381  H HG3  . ARG A 1 42  ? 5.90393   5.72955   22.77104 1.000 243.83774 ? 80  ARG A HG3  1 
ATOM 382  H HD2  . ARG A 1 42  ? 4.38590   7.37356   22.24562 1.000 253.57867 ? 80  ARG A HD2  1 
ATOM 383  H HD3  . ARG A 1 42  ? 3.71351   5.96760   21.93481 1.000 253.57867 ? 80  ARG A HD3  1 
ATOM 384  H HE   . ARG A 1 42  ? 3.02787   6.91850   24.33349 1.000 314.75654 ? 80  ARG A HE   1 
ATOM 385  H HH11 . ARG A 1 42  ? 2.01572   6.92993   21.16960 1.000 272.39477 ? 80  ARG A HH11 1 
ATOM 386  H HH12 . ARG A 1 42  ? 0.62388   7.37386   21.46027 1.000 272.39477 ? 80  ARG A HH12 1 
ATOM 387  H HH21 . ARG A 1 42  ? 0.92110   7.60238   24.72950 1.000 263.40760 ? 80  ARG A HH21 1 
ATOM 388  H HH22 . ARG A 1 42  ? -0.03617  7.77842   23.60192 1.000 263.40760 ? 80  ARG A HH22 1 
ATOM 389  N N    . GLN A 1 43  ? 5.02015   1.40902   24.64483 1.000 166.72636 ? 81  GLN A N    1 
ATOM 390  C CA   . GLN A 1 43  ? 4.57190   0.21910   25.36319 1.000 181.36344 ? 81  GLN A CA   1 
ATOM 391  C C    . GLN A 1 43  ? 5.67002   -0.35683  26.24560 1.000 163.65884 ? 81  GLN A C    1 
ATOM 392  O O    . GLN A 1 43  ? 5.40009   -0.79580  27.36487 1.000 170.45766 ? 81  GLN A O    1 
ATOM 393  C CB   . GLN A 1 43  ? 4.10364   -0.84813  24.37794 1.000 183.43854 ? 81  GLN A CB   1 
ATOM 394  C CG   . GLN A 1 43  ? 2.73092   -0.61779  23.81808 1.000 183.07238 ? 81  GLN A CG   1 
ATOM 395  C CD   . GLN A 1 43  ? 2.20367   -1.82821  23.08206 1.000 188.53793 ? 81  GLN A CD   1 
ATOM 396  O OE1  . GLN A 1 43  ? 2.91641   -2.81247  22.88940 1.000 210.26998 ? 81  GLN A OE1  1 
ATOM 397  N NE2  . GLN A 1 43  ? 0.95049   -1.76046  22.66112 1.000 221.38613 ? 81  GLN A NE2  1 
ATOM 398  H H    . GLN A 1 43  ? 5.00580   1.33677   23.78799 1.000 202.61723 ? 81  GLN A H    1 
ATOM 399  H HA   . GLN A 1 43  ? 3.82617   0.47664   25.92751 1.000 220.18173 ? 81  GLN A HA   1 
ATOM 400  H HB2  . GLN A 1 43  ? 4.72369   -0.87381  23.63244 1.000 222.67185 ? 81  GLN A HB2  1 
ATOM 401  H HB3  . GLN A 1 43  ? 4.09497   -1.70530  24.83191 1.000 222.67185 ? 81  GLN A HB3  1 
ATOM 402  H HG2  . GLN A 1 43  ? 2.12063   -0.41626  24.54460 1.000 222.23246 ? 81  GLN A HG2  1 
ATOM 403  H HG3  . GLN A 1 43  ? 2.76187   0.12504   23.19507 1.000 222.23246 ? 81  GLN A HG3  1 
ATOM 404  H HE21 . GLN A 1 43  ? 0.48388   -1.05393  22.81175 1.000 268.20896 ? 81  GLN A HE21 1 
ATOM 405  H HE22 . GLN A 1 43  ? 0.60293   -2.42298  22.23701 1.000 268.20896 ? 81  GLN A HE22 1 
ATOM 406  N N    . ALA A 1 44  ? 6.90114   -0.42282  25.73909 1.000 178.81631 ? 82  ALA A N    1 
ATOM 407  C CA   . ALA A 1 44  ? 7.99935   -0.95567  26.54598 1.000 216.90516 ? 82  ALA A CA   1 
ATOM 408  C C    . ALA A 1 44  ? 8.27564   -0.08518  27.77058 1.000 208.66902 ? 82  ALA A C    1 
ATOM 409  O O    . ALA A 1 44  ? 8.48047   -0.60077  28.88243 1.000 229.52112 ? 82  ALA A O    1 
ATOM 410  C CB   . ALA A 1 44  ? 9.25679   -1.08882  25.68912 1.000 238.24112 ? 82  ALA A CB   1 
ATOM 411  H H    . ALA A 1 44  ? 7.12401   -0.17121  24.94749 1.000 217.12518 ? 82  ALA A H    1 
ATOM 412  H HA   . ALA A 1 44  ? 7.74990   -1.83805  26.86235 1.000 262.83180 ? 82  ALA A HA   1 
ATOM 413  H HB1  . ALA A 1 44  ? 9.05753   -1.64567  24.92028 1.000 288.43494 ? 82  ALA A HB1  1 
ATOM 414  H HB2  . ALA A 1 44  ? 9.53390   -0.20674  25.39577 1.000 288.43494 ? 82  ALA A HB2  1 
ATOM 415  H HB3  . ALA A 1 44  ? 9.95887   -1.49663  26.21985 1.000 288.43494 ? 82  ALA A HB3  1 
ATOM 416  N N    . GLU A 1 45  ? 8.22027   1.24021   27.60140 1.000 177.85677 ? 83  GLU A N    1 
ATOM 417  C CA   . GLU A 1 45  ? 8.41626   2.13218   28.74382 1.000 162.89082 ? 83  GLU A CA   1 
ATOM 418  C C    . GLU A 1 45  ? 7.34184   1.89553   29.79679 1.000 156.83433 ? 83  GLU A C    1 
ATOM 419  O O    . GLU A 1 45  ? 7.63071   1.78010   31.00143 1.000 153.33696 ? 83  GLU A O    1 
ATOM 420  C CB   . GLU A 1 45  ? 8.39674   3.58703   28.27463 1.000 193.92261 ? 83  GLU A CB   1 
ATOM 421  C CG   . GLU A 1 45  ? 9.53165   3.95115   27.33145 1.000 223.43519 ? 83  GLU A CG   1 
ATOM 422  C CD   . GLU A 1 45  ? 9.37163   5.33528   26.73580 1.000 207.23888 ? 83  GLU A CD   1 
ATOM 423  O OE1  . GLU A 1 45  ? 8.22494   5.82423   26.66531 1.000 205.98722 ? 83  GLU A OE1  1 
ATOM 424  O OE2  . GLU A 1 45  ? 10.39144  5.93236   26.33436 1.000 183.86320 ? 83  GLU A OE2  1 
ATOM 425  H H    . GLU A 1 45  ? 8.07411   1.63775   26.85293 1.000 215.97373 ? 83  GLU A H    1 
ATOM 426  H HA   . GLU A 1 45  ? 9.28232   1.95803   29.14447 1.000 198.01459 ? 83  GLU A HA   1 
ATOM 427  H HB2  . GLU A 1 45  ? 7.56213   3.75161   27.80853 1.000 235.25274 ? 83  GLU A HB2  1 
ATOM 428  H HB3  . GLU A 1 45  ? 8.46246   4.16447   29.05126 1.000 235.25274 ? 83  GLU A HB3  1 
ATOM 429  H HG2  . GLU A 1 45  ? 10.36920  3.92912   27.82024 1.000 270.66783 ? 83  GLU A HG2  1 
ATOM 430  H HG3  . GLU A 1 45  ? 9.55576   3.31121   26.60290 1.000 270.66783 ? 83  GLU A HG3  1 
ATOM 431  N N    . MET A 1 46  ? 6.09722   1.76267   29.34996 1.000 167.16215 ? 84  MET A N    1 
ATOM 432  C CA   . MET A 1 46  ? 5.00594   1.55827   30.28720 1.000 171.66376 ? 84  MET A CA   1 
ATOM 433  C C    . MET A 1 46  ? 5.04445   0.17002   30.91398 1.000 165.66977 ? 84  MET A C    1 
ATOM 434  O O    . MET A 1 46  ? 4.63479   0.00938   32.06723 1.000 162.04885 ? 84  MET A O    1 
ATOM 435  C CB   . MET A 1 46  ? 3.67661   1.76118   29.58407 1.000 197.40012 ? 84  MET A CB   1 
ATOM 436  C CG   . MET A 1 46  ? 2.56075   2.08989   30.52158 1.000 221.04218 ? 84  MET A CG   1 
ATOM 437  S SD   . MET A 1 46  ? 1.06441   1.41302   29.85256 1.000 292.19962 ? 84  MET A SD   1 
ATOM 438  C CE   . MET A 1 46  ? 0.62127   2.66483   28.68023 1.000 170.33273 ? 84  MET A CE   1 
ATOM 439  H H    . MET A 1 46  ? 5.86355   1.78690   28.52267 1.000 203.14019 ? 84  MET A H    1 
ATOM 440  H HA   . MET A 1 46  ? 5.08651   2.22098   30.99092 1.000 208.54212 ? 84  MET A HA   1 
ATOM 441  H HB2  . MET A 1 46  ? 3.76302   2.49360   28.95399 1.000 239.42575 ? 84  MET A HB2  1 
ATOM 442  H HB3  . MET A 1 46  ? 3.44183   0.94554   29.11449 1.000 239.42575 ? 84  MET A HB3  1 
ATOM 443  H HG2  . MET A 1 46  ? 2.72871   1.69596   31.39193 1.000 267.79622 ? 84  MET A HG2  1 
ATOM 444  H HG3  . MET A 1 46  ? 2.46715   3.05173   30.60525 1.000 267.79622 ? 84  MET A HG3  1 
ATOM 445  H HE1  . MET A 1 46  ? -0.25879  2.46639   28.32383 1.000 206.94488 ? 84  MET A HE1  1 
ATOM 446  H HE2  . MET A 1 46  ? 0.61094   3.52600   29.12652 1.000 206.94488 ? 84  MET A HE2  1 
ATOM 447  H HE3  . MET A 1 46  ? 1.27465   2.67161   27.96332 1.000 206.94488 ? 84  MET A HE3  1 
ATOM 448  N N    . GLU A 1 47  ? 5.48957   -0.84656  30.16973 1.000 172.45831 ? 85  GLU A N    1 
ATOM 449  C CA   . GLU A 1 47  ? 5.62178   -2.17965  30.74598 1.000 206.14910 ? 85  GLU A CA   1 
ATOM 450  C C    . GLU A 1 47  ? 6.66686   -2.20080  31.84890 1.000 209.65574 ? 85  GLU A C    1 
ATOM 451  O O    . GLU A 1 47  ? 6.46789   -2.83909  32.89074 1.000 208.07337 ? 85  GLU A O    1 
ATOM 452  C CB   . GLU A 1 47  ? 6.02386   -3.18847  29.66424 1.000 237.37881 ? 85  GLU A CB   1 
ATOM 453  C CG   . GLU A 1 47  ? 4.88738   -3.67550  28.79224 1.000 268.73656 ? 85  GLU A CG   1 
ATOM 454  C CD   . GLU A 1 47  ? 5.34480   -4.29570  27.48526 1.000 262.36842 ? 85  GLU A CD   1 
ATOM 455  O OE1  . GLU A 1 47  ? 6.55598   -4.26508  27.18407 1.000 234.51029 ? 85  GLU A OE1  1 
ATOM 456  O OE2  . GLU A 1 47  ? 4.47954   -4.82803  26.76037 1.000 267.13000 ? 85  GLU A OE2  1 
ATOM 457  H H    . GLU A 1 47  ? 5.71731   -0.78913  29.34242 1.000 209.49558 ? 85  GLU A H    1 
ATOM 458  H HA   . GLU A 1 47  ? 4.76146   -2.43482  31.11427 1.000 249.92452 ? 85  GLU A HA   1 
ATOM 459  H HB2  . GLU A 1 47  ? 6.67856   -2.77096  29.08290 1.000 287.40017 ? 85  GLU A HB2  1 
ATOM 460  H HB3  . GLU A 1 47  ? 6.41193   -3.96488  30.09723 1.000 287.40017 ? 85  GLU A HB3  1 
ATOM 461  H HG2  . GLU A 1 47  ? 4.38567   -4.34778  29.27930 1.000 325.02948 ? 85  GLU A HG2  1 
ATOM 462  H HG3  . GLU A 1 47  ? 4.31331   -2.92351  28.57812 1.000 325.02948 ? 85  GLU A HG3  1 
ATOM 463  N N    . GLY A 1 48  ? 7.75255   -1.44547  31.67575 1.000 199.15948 ? 86  GLY A N    1 
ATOM 464  C CA   . GLY A 1 48  ? 8.70090   -1.29807  32.76891 1.000 194.19729 ? 86  GLY A CA   1 
ATOM 465  C C    . GLY A 1 48  ? 8.11525   -0.58795  33.97547 1.000 202.28599 ? 86  GLY A C    1 
ATOM 466  O O    . GLY A 1 48  ? 8.31169   -1.01665  35.11893 1.000 208.46796 ? 86  GLY A O    1 
ATOM 467  H H    . GLY A 1 48  ? 7.95477   -1.02146  30.95539 1.000 241.53698 ? 86  GLY A H    1 
ATOM 468  H HA2  . GLY A 1 48  ? 9.00019   -2.17661  33.05086 1.000 235.58235 ? 86  GLY A HA2  1 
ATOM 469  H HA3  . GLY A 1 48  ? 9.46585   -0.78805  32.45965 1.000 235.58235 ? 86  GLY A HA3  1 
ATOM 470  N N    . ALA A 1 49  ? 7.35221   0.48155   33.73971 1.000 189.34671 ? 87  ALA A N    1 
ATOM 471  C CA   . ALA A 1 49  ? 6.73493   1.19024   34.86085 1.000 171.89674 ? 87  ALA A CA   1 
ATOM 472  C C    . ALA A 1 49  ? 5.72631   0.31957   35.61418 1.000 198.24891 ? 87  ALA A C    1 
ATOM 473  O O    . ALA A 1 49  ? 5.71670   0.28856   36.85587 1.000 199.91510 ? 87  ALA A O    1 
ATOM 474  C CB   . ALA A 1 49  ? 6.06083   2.46272   34.35109 1.000 155.86705 ? 87  ALA A CB   1 
ATOM 475  H H    . ALA A 1 49  ? 7.18095   0.80798   32.96272 1.000 229.76166 ? 87  ALA A H    1 
ATOM 476  H HA   . ALA A 1 49  ? 7.43233   1.43264   35.48996 1.000 208.82169 ? 87  ALA A HA   1 
ATOM 477  H HB1  . ALA A 1 49  ? 6.71358   2.99479   33.86971 1.000 189.58606 ? 87  ALA A HB1  1 
ATOM 478  H HB2  . ALA A 1 49  ? 5.33191   2.21868   33.75947 1.000 189.58606 ? 87  ALA A HB2  1 
ATOM 479  H HB3  . ALA A 1 49  ? 5.71892   2.96390   35.10794 1.000 189.58606 ? 87  ALA A HB3  1 
ATOM 480  N N    . VAL A 1 50  ? 4.89781   -0.42741  34.88238 1.000 193.53804 ? 88  VAL A N    1 
ATOM 481  C CA   . VAL A 1 50  ? 3.92562   -1.31260  35.51736 1.000 187.02283 ? 88  VAL A CA   1 
ATOM 482  C C    . VAL A 1 50  ? 4.61761   -2.43389  36.28194 1.000 209.10844 ? 88  VAL A C    1 
ATOM 483  O O    . VAL A 1 50  ? 4.17696   -2.81279  37.37174 1.000 223.76709 ? 88  VAL A O    1 
ATOM 484  C CB   . VAL A 1 50  ? 2.94912   -1.86817  34.46370 1.000 192.58060 ? 88  VAL A CB   1 
ATOM 485  C CG1  . VAL A 1 50  ? 2.09763   -2.98761  35.05384 1.000 211.51937 ? 88  VAL A CG1  1 
ATOM 486  C CG2  . VAL A 1 50  ? 2.06636   -0.75728  33.92113 1.000 207.36564 ? 88  VAL A CG2  1 
ATOM 487  H H    . VAL A 1 50  ? 4.87908   -0.43941  34.02267 1.000 234.79126 ? 88  VAL A H    1 
ATOM 488  H HA   . VAL A 1 50  ? 3.42010   -0.79147  36.16060 1.000 226.97300 ? 88  VAL A HA   1 
ATOM 489  H HB   . VAL A 1 50  ? 3.46221   -2.23734  33.72794 1.000 233.64232 ? 88  VAL A HB   1 
ATOM 490  H HG11 . VAL A 1 50  ? 1.44307   -3.26738  34.39492 1.000 256.36885 ? 88  VAL A HG11 1 
ATOM 491  H HG12 . VAL A 1 50  ? 2.67302   -3.73327  35.28581 1.000 256.36885 ? 88  VAL A HG12 1 
ATOM 492  H HG13 . VAL A 1 50  ? 1.64790   -2.65749  35.84736 1.000 256.36885 ? 88  VAL A HG13 1 
ATOM 493  H HG21 . VAL A 1 50  ? 2.62899   -0.05857  33.55212 1.000 251.38437 ? 88  VAL A HG21 1 
ATOM 494  H HG22 . VAL A 1 50  ? 1.49221   -1.11995  33.22851 1.000 251.38437 ? 88  VAL A HG22 1 
ATOM 495  H HG23 . VAL A 1 50  ? 1.52736   -0.40050  34.64437 1.000 251.38437 ? 88  VAL A HG23 1 
ATOM 496  N N    . GLN A 1 51  ? 5.66428   -3.02898  35.70543 1.000 216.36242 ? 89  GLN A N    1 
ATOM 497  C CA   . GLN A 1 51  ? 6.40812   -4.05827  36.42621 1.000 207.39129 ? 89  GLN A CA   1 
ATOM 498  C C    . GLN A 1 51  ? 7.03400   -3.51083  37.70576 1.000 200.04953 ? 89  GLN A C    1 
ATOM 499  O O    . GLN A 1 51  ? 7.07703   -4.20395  38.73031 1.000 208.23759 ? 89  GLN A O    1 
ATOM 500  C CB   . GLN A 1 51  ? 7.45916   -4.67028  35.50500 1.000 206.44394 ? 89  GLN A CB   1 
ATOM 501  C CG   . GLN A 1 51  ? 6.83496   -5.61022  34.48852 1.000 243.07699 ? 89  GLN A CG   1 
ATOM 502  C CD   . GLN A 1 51  ? 7.78125   -6.01062  33.37913 1.000 241.41794 ? 89  GLN A CD   1 
ATOM 503  O OE1  . GLN A 1 51  ? 8.95903   -5.65435  33.38770 1.000 232.20114 ? 89  GLN A OE1  1 
ATOM 504  N NE2  . GLN A 1 51  ? 7.26318   -6.75298  32.40655 1.000 238.49452 ? 89  GLN A NE2  1 
ATOM 505  H H    . GLN A 1 51  ? 5.95701   -2.85796  34.91507 1.000 262.18050 ? 89  GLN A H    1 
ATOM 506  H HA   . GLN A 1 51  ? 5.79832   -4.76442  36.69154 1.000 251.41516 ? 89  GLN A HA   1 
ATOM 507  H HB2  . GLN A 1 51  ? 7.91547   -3.96153  35.02505 1.000 250.27833 ? 89  GLN A HB2  1 
ATOM 508  H HB3  . GLN A 1 51  ? 8.09539   -5.17434  36.03606 1.000 250.27833 ? 89  GLN A HB3  1 
ATOM 509  H HG2  . GLN A 1 51  ? 6.55046   -6.41880  34.94256 1.000 294.23800 ? 89  GLN A HG2  1 
ATOM 510  H HG3  . GLN A 1 51  ? 6.07094   -5.17102  34.08319 1.000 294.23800 ? 89  GLN A HG3  1 
ATOM 511  H HE21 . GLN A 1 51  ? 6.43354   -6.97795  32.43275 1.000 288.73903 ? 89  GLN A HE21 1 
ATOM 512  H HE22 . GLN A 1 51  ? 7.75750   -7.00852  31.75084 1.000 288.73903 ? 89  GLN A HE22 1 
ATOM 513  N N    . SER A 1 52  ? 7.49744   -2.25863  37.67896 1.000 211.65881 ? 90  SER A N    1 
ATOM 514  C CA   . SER A 1 52  ? 8.02731   -1.64869  38.89673 1.000 221.64501 ? 90  SER A CA   1 
ATOM 515  C C    . SER A 1 52  ? 6.93906   -1.47913  39.95243 1.000 196.59077 ? 90  SER A C    1 
ATOM 516  O O    . SER A 1 52  ? 7.16411   -1.74460  41.14248 1.000 186.60774 ? 90  SER A O    1 
ATOM 517  C CB   . SER A 1 52  ? 8.65496   -0.29277  38.56974 1.000 193.35286 ? 90  SER A CB   1 
ATOM 518  O OG   . SER A 1 52  ? 10.00830  -0.42568  38.17379 1.000 190.38231 ? 90  SER A OG   1 
ATOM 519  H H    . SER A 1 52  ? 7.51557   -1.75272  36.98375 1.000 256.53618 ? 90  SER A H    1 
ATOM 520  H HA   . SER A 1 52  ? 8.71544   -2.22846  39.25902 1.000 268.51961 ? 90  SER A HA   1 
ATOM 521  H HB2  . SER A 1 52  ? 8.15603   0.11608   37.84531 1.000 234.56904 ? 90  SER A HB2  1 
ATOM 522  H HB3  . SER A 1 52  ? 8.61403   0.26919   39.35932 1.000 234.56904 ? 90  SER A HB3  1 
ATOM 523  H HG   . SER A 1 52  ? 10.26667  0.27722   37.79330 1.000 231.00438 ? 90  SER A HG   1 
ATOM 524  N N    . ILE A 1 53  ? 5.73498   -1.09181  39.52618 1.000 191.81341 ? 91  ILE A N    1 
ATOM 525  C CA   . ILE A 1 53  ? 4.61646   -0.97887  40.46412 1.000 211.26736 ? 91  ILE A CA   1 
ATOM 526  C C    . ILE A 1 53  ? 4.24673   -2.34521  41.03469 1.000 225.20637 ? 91  ILE A C    1 
ATOM 527  O O    . ILE A 1 53  ? 3.97177   -2.48503  42.23558 1.000 243.78414 ? 91  ILE A O    1 
ATOM 528  C CB   . ILE A 1 53  ? 3.40978   -0.33578  39.75674 1.000 247.20171 ? 91  ILE A CB   1 
ATOM 529  C CG1  . ILE A 1 53  ? 3.71220   1.11461   39.40189 1.000 215.65544 ? 91  ILE A CG1  1 
ATOM 530  C CG2  . ILE A 1 53  ? 2.16756   -0.40815  40.63406 1.000 261.84630 ? 91  ILE A CG2  1 
ATOM 531  C CD1  . ILE A 1 53  ? 2.82528   1.62503   38.30773 1.000 205.13133 ? 91  ILE A CD1  1 
ATOM 532  H H    . ILE A 1 53  ? 5.54174   -0.89171  38.71241 1.000 232.72169 ? 91  ILE A H    1 
ATOM 533  H HA   . ILE A 1 53  ? 4.89103   -0.41133  41.20127 1.000 256.06644 ? 91  ILE A HA   1 
ATOM 534  H HB   . ILE A 1 53  ? 3.24335   -0.83213  38.94013 1.000 299.18765 ? 91  ILE A HB   1 
ATOM 535  H HG12 . ILE A 1 53  ? 3.57557   1.66906   40.18600 1.000 261.33213 ? 91  ILE A HG12 1 
ATOM 536  H HG13 . ILE A 1 53  ? 4.63239   1.18373   39.10295 1.000 261.33213 ? 91  ILE A HG13 1 
ATOM 537  H HG21 . ILE A 1 53  ? 1.44191   0.06099   40.19334 1.000 316.76117 ? 91  ILE A HG21 1 
ATOM 538  H HG22 . ILE A 1 53  ? 1.92791   -1.33877  40.76602 1.000 316.76117 ? 91  ILE A HG22 1 
ATOM 539  H HG23 . ILE A 1 53  ? 2.35986   0.00829   41.48875 1.000 316.76117 ? 91  ILE A HG23 1 
ATOM 540  H HD11 . ILE A 1 53  ? 3.10904   2.51963   38.06265 1.000 248.70320 ? 91  ILE A HD11 1 
ATOM 541  H HD12 . ILE A 1 53  ? 1.90943   1.64425   38.62670 1.000 248.70320 ? 91  ILE A HD12 1 
ATOM 542  H HD13 . ILE A 1 53  ? 2.89649   1.03398   37.54190 1.000 248.70320 ? 91  ILE A HD13 1 
ATOM 543  N N    . GLN A 1 54  ? 4.17637   -3.35983  40.17291 1.000 215.70594 ? 92  GLN A N    1 
ATOM 544  C CA   . GLN A 1 54  ? 3.86022   -4.70952  40.62687 1.000 221.49683 ? 92  GLN A CA   1 
ATOM 545  C C    . GLN A 1 54  ? 4.87721   -5.21298  41.63813 1.000 236.25657 ? 92  GLN A C    1 
ATOM 546  O O    . GLN A 1 54  ? 4.51356   -5.85254  42.63211 1.000 287.12508 ? 92  GLN A O    1 
ATOM 547  C CB   . GLN A 1 54  ? 3.81610   -5.65298  39.42952 1.000 211.72145 ? 92  GLN A CB   1 
ATOM 548  C CG   . GLN A 1 54  ? 2.57859   -5.49495  38.59316 1.000 220.72810 ? 92  GLN A CG   1 
ATOM 549  C CD   . GLN A 1 54  ? 2.56253   -6.40073  37.38289 1.000 215.79450 ? 92  GLN A CD   1 
ATOM 550  O OE1  . GLN A 1 54  ? 3.61019   -6.78184  36.86096 1.000 185.25835 ? 92  GLN A OE1  1 
ATOM 551  N NE2  . GLN A 1 54  ? 1.36758   -6.74368  36.92265 1.000 237.72146 ? 92  GLN A NE2  1 
ATOM 552  H H    . GLN A 1 54  ? 4.30675   -3.29297  39.32549 1.000 261.39273 ? 92  GLN A H    1 
ATOM 553  H HA   . GLN A 1 54  ? 2.98946   -4.69589  41.05406 1.000 268.34180 ? 92  GLN A HA   1 
ATOM 554  H HB2  . GLN A 1 54  ? 4.58329   -5.47638  38.86284 1.000 256.61134 ? 92  GLN A HB2  1 
ATOM 555  H HB3  . GLN A 1 54  ? 3.84415   -6.56800  39.75023 1.000 256.61134 ? 92  GLN A HB3  1 
ATOM 556  H HG2  . GLN A 1 54  ? 1.80277   -5.70713  39.13535 1.000 267.41932 ? 92  GLN A HG2  1 
ATOM 557  H HG3  . GLN A 1 54  ? 2.52443   -4.57819  38.28088 1.000 267.41932 ? 92  GLN A HG3  1 
ATOM 558  H HE21 . GLN A 1 54  ? 0.65751   -6.45240  37.31066 1.000 287.81135 ? 92  GLN A HE21 1 
ATOM 559  H HE22 . GLN A 1 54  ? 1.30244   -7.25746  36.23607 1.000 287.81135 ? 92  GLN A HE22 1 
ATOM 560  N N    . GLY A 1 55  ? 6.15699   -4.91922  41.41077 1.000 216.88008 ? 93  GLY A N    1 
ATOM 561  C CA   . GLY A 1 55  ? 7.16774   -5.29129  42.38280 1.000 219.27208 ? 93  GLY A CA   1 
ATOM 562  C C    . GLY A 1 55  ? 7.01511   -4.55804  43.69926 1.000 218.65252 ? 93  GLY A C    1 
ATOM 563  O O    . GLY A 1 55  ? 7.19625   -5.14349  44.77071 1.000 229.96224 ? 93  GLY A O    1 
ATOM 564  H H    . GLY A 1 55  ? 6.45618   -4.51307  40.71425 1.000 262.80170 ? 93  GLY A H    1 
ATOM 565  H HA2  . GLY A 1 55  ? 7.10810   -6.24369  42.55677 1.000 265.67209 ? 93  GLY A HA2  1 
ATOM 566  H HA3  . GLY A 1 55  ? 8.04589   -5.09035  42.02310 1.000 265.67209 ? 93  GLY A HA3  1 
ATOM 567  N N    . GLU A 1 56  ? 6.68995   -3.26594  43.64215 1.000 229.58822 ? 94  GLU A N    1 
ATOM 568  C CA   . GLU A 1 56  ? 6.44935   -2.52780  44.87695 1.000 212.66878 ? 94  GLU A CA   1 
ATOM 569  C C    . GLU A 1 56  ? 5.27621   -3.10682  45.66666 1.000 236.14310 ? 94  GLU A C    1 
ATOM 570  O O    . GLU A 1 56  ? 5.34147   -3.20798  46.89734 1.000 231.27700 ? 94  GLU A O    1 
ATOM 571  C CB   . GLU A 1 56  ? 6.18945   -1.05720  44.54031 1.000 232.05059 ? 94  GLU A CB   1 
ATOM 572  C CG   . GLU A 1 56  ? 5.76005   -0.17459  45.70937 1.000 243.50175 ? 94  GLU A CG   1 
ATOM 573  C CD   . GLU A 1 56  ? 6.90650   0.11909   46.65674 1.000 232.29113 ? 94  GLU A CD   1 
ATOM 574  O OE1  . GLU A 1 56  ? 8.04155   -0.30710  46.35889 1.000 240.26130 ? 94  GLU A OE1  1 
ATOM 575  O OE2  . GLU A 1 56  ? 6.67561   0.77799   47.69206 1.000 235.72362 ? 94  GLU A OE2  1 
ATOM 576  H H    . GLU A 1 56  ? 6.60476   -2.80673  42.92002 1.000 278.05147 ? 94  GLU A H    1 
ATOM 577  H HA   . GLU A 1 56  ? 7.23748   -2.59009  45.43897 1.000 257.74814 ? 94  GLU A HA   1 
ATOM 578  H HB2  . GLU A 1 56  ? 7.00656   -0.67898  44.17949 1.000 281.00631 ? 94  GLU A HB2  1 
ATOM 579  H HB3  . GLU A 1 56  ? 5.48387   -1.01759  43.87585 1.000 281.00631 ? 94  GLU A HB3  1 
ATOM 580  H HG2  . GLU A 1 56  ? 5.42813   0.66956   45.36566 1.000 294.74770 ? 94  GLU A HG2  1 
ATOM 581  H HG3  . GLU A 1 56  ? 5.06258   -0.62632  46.20974 1.000 294.74770 ? 94  GLU A HG3  1 
ATOM 582  N N    . LEU A 1 57  ? 4.19091   -3.48553  44.98366 1.000 243.08654 ? 95  LEU A N    1 
ATOM 583  C CA   . LEU A 1 57  ? 3.03051   -4.04777  45.67571 1.000 232.93008 ? 95  LEU A CA   1 
ATOM 584  C C    . LEU A 1 57  ? 3.14617   -5.52487  46.02032 1.000 264.22058 ? 95  LEU A C    1 
ATOM 585  O O    . LEU A 1 57  ? 2.32988   -6.02470  46.80269 1.000 258.64059 ? 95  LEU A O    1 
ATOM 586  C CB   . LEU A 1 57  ? 1.77654   -3.85562  44.82883 1.000 215.03531 ? 95  LEU A CB   1 
ATOM 587  C CG   . LEU A 1 57  ? 1.41807   -2.39424  44.60179 1.000 237.14935 ? 95  LEU A CG   1 
ATOM 588  C CD1  . LEU A 1 57  ? 0.22196   -2.30481  43.67859 1.000 268.15150 ? 95  LEU A CD1  1 
ATOM 589  C CD2  . LEU A 1 57  ? 1.15203   -1.71136  45.92552 1.000 264.30628 ? 95  LEU A CD2  1 
ATOM 590  H H    . LEU A 1 57  ? 4.10464   -3.42721  44.12999 1.000 294.24945 ? 95  LEU A H    1 
ATOM 591  H HA   . LEU A 1 57  ? 2.93886   -3.56228  46.51046 1.000 282.06170 ? 95  LEU A HA   1 
ATOM 592  H HB2  . LEU A 1 57  ? 1.91934   -4.26586  43.96153 1.000 260.58797 ? 95  LEU A HB2  1 
ATOM 593  H HB3  . LEU A 1 57  ? 1.02848   -4.27995  45.27743 1.000 260.58797 ? 95  LEU A HB3  1 
ATOM 594  H HG   . LEU A 1 57  ? 2.15672   -1.92788  44.18012 1.000 287.12482 ? 95  LEU A HG   1 
ATOM 595  H HD11 . LEU A 1 57  ? 0.43662   -2.74302  42.84026 1.000 324.32740 ? 95  LEU A HD11 1 
ATOM 596  H HD12 . LEU A 1 57  ? 0.01465   -1.37060  43.51991 1.000 324.32740 ? 95  LEU A HD12 1 
ATOM 597  H HD13 . LEU A 1 57  ? -0.53408  -2.74483  44.09774 1.000 324.32740 ? 95  LEU A HD13 1 
ATOM 598  H HD21 . LEU A 1 57  ? 0.81719   -0.81660  45.75761 1.000 319.71314 ? 95  LEU A HD21 1 
ATOM 599  H HD22 . LEU A 1 57  ? 0.49261   -2.22420  46.41853 1.000 319.71314 ? 95  LEU A HD22 1 
ATOM 600  H HD23 . LEU A 1 57  ? 1.97971   -1.66568  46.42927 1.000 319.71314 ? 95  LEU A HD23 1 
ATOM 601  N N    . SER A 1 58  ? 4.12442   -6.23030  45.47054 1.000 294.33294 ? 96  SER A N    1 
ATOM 602  C CA   . SER A 1 58  ? 4.26188   -7.66334  45.67446 1.000 273.42569 ? 96  SER A CA   1 
ATOM 603  C C    . SER A 1 58  ? 5.40045   -8.02662  46.60407 1.000 286.33204 ? 96  SER A C    1 
ATOM 604  O O    . SER A 1 58  ? 5.45969   -9.17160  47.06687 1.000 267.68798 ? 96  SER A O    1 
ATOM 605  C CB   . SER A 1 58  ? 4.45342   -8.38871  44.33534 1.000 244.05380 ? 96  SER A CB   1 
ATOM 606  O OG   . SER A 1 58  ? 3.37039   -8.12871  43.46129 1.000 211.24242 ? 96  SER A OG   1 
ATOM 607  H H    . SER A 1 58  ? 4.73344   -5.89420  44.96484 1.000 355.74513 ? 96  SER A H    1 
ATOM 608  H HA   . SER A 1 58  ? 3.43874   -7.99531  46.06578 1.000 330.65643 ? 96  SER A HA   1 
ATOM 609  H HB2  . SER A 1 58  ? 5.27406   -8.07745  43.92234 1.000 295.41017 ? 96  SER A HB2  1 
ATOM 610  H HB3  . SER A 1 58  ? 4.50538   -9.34353  44.49819 1.000 295.41017 ? 96  SER A HB3  1 
ATOM 611  H HG   . SER A 1 58  ? 3.47813   -8.54372  42.73897 1.000 256.03651 ? 96  SER A HG   1 
ATOM 612  N N    . LYS A 1 59  ? 6.28883   -7.09006  46.90327 1.000 274.93170 ? 97  LYS A N    1 
ATOM 613  C CA   . LYS A 1 59  ? 7.45578   -7.43944  47.67935 1.000 273.28264 ? 97  LYS A CA   1 
ATOM 614  C C    . LYS A 1 59  ? 7.06307   -7.88549  49.08067 1.000 300.14579 ? 97  LYS A C    1 
ATOM 615  O O    . LYS A 1 59  ? 6.00177   -7.53833  49.60776 1.000 315.10523 ? 97  LYS A O    1 
ATOM 616  C CB   . LYS A 1 59  ? 8.36865   -6.20659  47.74037 1.000 253.23820 ? 97  LYS A CB   1 
ATOM 617  C CG   . LYS A 1 59  ? 7.81951   -5.04712  48.60471 1.000 231.85254 ? 97  LYS A CG   1 
ATOM 618  C CD   . LYS A 1 59  ? 8.66137   -3.78066  48.41949 1.000 225.64912 ? 97  LYS A CD   1 
ATOM 619  C CE   . LYS A 1 59  ? 8.26416   -2.62449  49.34397 1.000 200.27482 ? 97  LYS A CE   1 
ATOM 620  N NZ   . LYS A 1 59  ? 9.05900   -1.40286  49.02339 1.000 286.47291 ? 97  LYS A NZ   1 
ATOM 621  H H    . LYS A 1 59  ? 6.23620   -6.26352  46.67164 1.000 332.46364 ? 97  LYS A H    1 
ATOM 622  H HA   . LYS A 1 59  ? 7.93433   -8.17970  47.27450 1.000 330.48477 ? 97  LYS A HA   1 
ATOM 623  H HB2  . LYS A 1 59  ? 9.22301   -6.47257  48.11483 1.000 306.43145 ? 97  LYS A HB2  1 
ATOM 624  H HB3  . LYS A 1 59  ? 8.49207   -5.86822  46.83972 1.000 306.43145 ? 97  LYS A HB3  1 
ATOM 625  H HG2  . LYS A 1 59  ? 6.90698   -4.85087  48.34073 1.000 280.76865 ? 97  LYS A HG2  1 
ATOM 626  H HG3  . LYS A 1 59  ? 7.84696   -5.30022  49.54071 1.000 280.76865 ? 97  LYS A HG3  1 
ATOM 627  H HD2  . LYS A 1 59  ? 9.59009   -3.99505  48.59954 1.000 273.32455 ? 97  LYS A HD2  1 
ATOM 628  H HD3  . LYS A 1 59  ? 8.56329   -3.47258  47.50496 1.000 273.32455 ? 97  LYS A HD3  1 
ATOM 629  H HE2  . LYS A 1 59  ? 7.32319   -2.42144  49.22455 1.000 242.87539 ? 97  LYS A HE2  1 
ATOM 630  H HE3  . LYS A 1 59  ? 8.43572   -2.87199  50.26603 1.000 242.87539 ? 97  LYS A HE3  1 
ATOM 631  H HZ1  . LYS A 1 59  ? 8.81569   -1.08087  48.23015 1.000 346.31309 ? 97  LYS A HZ1  1 
ATOM 632  H HZ2  . LYS A 1 59  ? 8.92139   -0.77891  49.64294 1.000 346.31309 ? 97  LYS A HZ2  1 
ATOM 633  H HZ3  . LYS A 1 59  ? 9.92632   -1.60124  49.00090 1.000 346.31309 ? 97  LYS A HZ3  1 
ATOM 634  N N    . LEU A 1 60  ? 7.95391   -8.64999  49.69991 1.000 311.53237 ? 98  LEU A N    1 
ATOM 635  C CA   . LEU A 1 60  ? 7.68618   -9.11104  51.04759 1.000 304.41799 ? 98  LEU A CA   1 
ATOM 636  C C    . LEU A 1 60  ? 7.98331   -7.89765  51.84798 1.000 298.72818 ? 98  LEU A C    1 
ATOM 637  O O    . LEU A 1 60  ? 8.67520   -6.98269  51.37645 1.000 307.29851 ? 98  LEU A O    1 
ATOM 638  C CB   . LEU A 1 60  ? 8.54824   -10.28587 51.50352 1.000 294.83241 ? 98  LEU A CB   1 
ATOM 639  C CG   . LEU A 1 60  ? 8.57224   -11.53317 50.63979 1.000 271.89231 ? 98  LEU A CG   1 
ATOM 640  C CD1  . LEU A 1 60  ? 9.36207   -12.59767 51.36562 1.000 229.69453 ? 98  LEU A CD1  1 
ATOM 641  C CD2  . LEU A 1 60  ? 7.15250   -11.98421 50.35437 1.000 248.31259 ? 98  LEU A CD2  1 
ATOM 642  H H    . LEU A 1 60  ? 8.70310   -8.90770  49.36539 1.000 376.38444 ? 98  LEU A H    1 
ATOM 643  H HA   . LEU A 1 60  ? 6.78950   -9.46656  51.14989 1.000 367.84720 ? 98  LEU A HA   1 
ATOM 644  H HB2  . LEU A 1 60  ? 9.46412   -9.97226  51.56441 1.000 356.34449 ? 98  LEU A HB2  1 
ATOM 645  H HB3  . LEU A 1 60  ? 8.23253   -10.55992 52.37881 1.000 356.34449 ? 98  LEU A HB3  1 
ATOM 646  H HG   . LEU A 1 60  ? 8.99608   -11.36401 49.78384 1.000 328.81637 ? 98  LEU A HG   1 
ATOM 647  H HD11 . LEU A 1 60  ? 10.25159  -12.25879 51.55221 1.000 278.17904 ? 98  LEU A HD11 1 
ATOM 648  H HD12 . LEU A 1 60  ? 9.41966   -13.38633 50.80384 1.000 278.17904 ? 98  LEU A HD12 1 
ATOM 649  H HD13 . LEU A 1 60  ? 8.91011   -12.81525 52.19586 1.000 278.17904 ? 98  LEU A HD13 1 
ATOM 650  H HD21 . LEU A 1 60  ? 6.69932   -12.15195 51.19544 1.000 300.52071 ? 98  LEU A HD21 1 
ATOM 651  H HD22 . LEU A 1 60  ? 7.17962   -12.79685 49.82543 1.000 300.52071 ? 98  LEU A HD22 1 
ATOM 652  H HD23 . LEU A 1 60  ? 6.69175   -11.28556 49.86397 1.000 300.52071 ? 98  LEU A HD23 1 
ATOM 653  N N    . GLN B 2 1   ? 12.23727  20.69961  8.13316  1.000 164.25819 ? 2   GLN B N    1 
ATOM 654  C CA   . GLN B 2 1   ? 11.35147  20.47809  9.31184  1.000 181.36590 ? 2   GLN B CA   1 
ATOM 655  C C    . GLN B 2 1   ? 9.90582   20.40328  8.85085  1.000 210.86066 ? 2   GLN B C    1 
ATOM 656  O O    . GLN B 2 1   ? 9.59211   20.75177  7.71195  1.000 231.50257 ? 2   GLN B O    1 
ATOM 657  C CB   . GLN B 2 1   ? 11.51637  21.58956  10.35213 1.000 171.72538 ? 2   GLN B CB   1 
ATOM 658  C CG   . GLN B 2 1   ? 12.46345  21.22375  11.48205 1.000 177.30121 ? 2   GLN B CG   1 
ATOM 659  C CD   . GLN B 2 1   ? 13.85579  20.88809  10.98788 1.000 166.54397 ? 2   GLN B CD   1 
ATOM 660  O OE1  . GLN B 2 1   ? 14.22117  21.20380  9.85725  1.000 141.93986 ? 2   GLN B OE1  1 
ATOM 661  N NE2  . GLN B 2 1   ? 14.63248  20.22276  11.82680 1.000 195.39516 ? 2   GLN B NE2  1 
ATOM 662  H H1   . GLN B 2 1   ? 11.90600  20.26925  7.42808  1.000 199.65543 ? 2   GLN B H1   1 
ATOM 663  H H2   . GLN B 2 1   ? 13.05263  20.39132  8.31274  1.000 199.65543 ? 2   GLN B H2   1 
ATOM 664  H H3   . GLN B 2 1   ? 12.28191  21.57048  7.95513  1.000 199.65543 ? 2   GLN B H3   1 
ATOM 665  H HA   . GLN B 2 1   ? 11.59509  19.64643  9.74760  1.000 220.18468 ? 2   GLN B HA   1 
ATOM 666  H HB2  . GLN B 2 1   ? 11.86825  22.37965  9.91300  1.000 208.61606 ? 2   GLN B HB2  1 
ATOM 667  H HB3  . GLN B 2 1   ? 10.64976  21.78476  10.74173 1.000 208.61606 ? 2   GLN B HB3  1 
ATOM 668  H HG2  . GLN B 2 1   ? 12.53372  21.97454  12.09218 1.000 215.30706 ? 2   GLN B HG2  1 
ATOM 669  H HG3  . GLN B 2 1   ? 12.11497  20.44825  11.94903 1.000 215.30706 ? 2   GLN B HG3  1 
ATOM 670  H HE21 . GLN B 2 1   ? 14.33783  20.00492  12.60482 1.000 237.01979 ? 2   GLN B HE21 1 
ATOM 671  H HE22 . GLN B 2 1   ? 15.43210  20.00803  11.59420 1.000 237.01979 ? 2   GLN B HE22 1 
ATOM 672  N N    . VAL B 2 2   ? 9.02506   19.94494  9.73268  1.000 217.32265 ? 3   VAL B N    1 
ATOM 673  C CA   . VAL B 2 2   ? 7.58858   20.07623  9.53592  1.000 181.20515 ? 3   VAL B CA   1 
ATOM 674  C C    . VAL B 2 2   ? 7.11984   21.31345  10.28476 1.000 150.01264 ? 3   VAL B C    1 
ATOM 675  O O    . VAL B 2 2   ? 7.48916   21.52537  11.44682 1.000 120.79173 ? 3   VAL B O    1 
ATOM 676  C CB   . VAL B 2 2   ? 6.84679   18.81617  10.01181 1.000 176.97602 ? 3   VAL B CB   1 
ATOM 677  C CG1  . VAL B 2 2   ? 5.33974   19.02669  9.96974  1.000 183.75907 ? 3   VAL B CG1  1 
ATOM 678  C CG2  . VAL B 2 2   ? 7.25324   17.62880  9.15878  1.000 191.78908 ? 3   VAL B CG2  1 
ATOM 679  H H    . VAL B 2 2   ? 9.24023   19.54777  10.46449 1.000 263.33279 ? 3   VAL B H    1 
ATOM 680  H HA   . VAL B 2 2   ? 7.39573   20.19895  8.59324  1.000 219.99179 ? 3   VAL B HA   1 
ATOM 681  H HB   . VAL B 2 2   ? 7.08841   18.63135  10.93288 1.000 214.91683 ? 3   VAL B HB   1 
ATOM 682  H HG11 . VAL B 2 2   ? 4.89822   18.19861  10.21518 1.000 223.05649 ? 3   VAL B HG11 1 
ATOM 683  H HG12 . VAL B 2 2   ? 5.10110   19.72724  10.59678 1.000 223.05649 ? 3   VAL B HG12 1 
ATOM 684  H HG13 . VAL B 2 2   ? 5.08195   19.28524  9.07108  1.000 223.05649 ? 3   VAL B HG13 1 
ATOM 685  H HG21 . VAL B 2 2   ? 6.75464   16.84800  9.44625  1.000 232.69250 ? 3   VAL B HG21 1 
ATOM 686  H HG22 . VAL B 2 2   ? 7.05451   17.82460  8.22976  1.000 232.69250 ? 3   VAL B HG22 1 
ATOM 687  H HG23 . VAL B 2 2   ? 8.20435   17.47249  9.26774  1.000 232.69250 ? 3   VAL B HG23 1 
ATOM 688  N N    . GLN B 2 3   ? 6.30952   22.12886  9.61746  1.000 161.61264 ? 4   GLN B N    1 
ATOM 689  C CA   . GLN B 2 3   ? 5.69214   23.30840  10.20638 1.000 147.78364 ? 4   GLN B CA   1 
ATOM 690  C C    . GLN B 2 3   ? 4.19918   23.06990  10.37143 1.000 158.16240 ? 4   GLN B C    1 
ATOM 691  O O    . GLN B 2 3   ? 3.53941   22.59587  9.44010  1.000 169.12461 ? 4   GLN B O    1 
ATOM 692  C CB   . GLN B 2 3   ? 5.94241   24.54022  9.33679  1.000 178.23397 ? 4   GLN B CB   1 
ATOM 693  C CG   . GLN B 2 3   ? 7.41430   24.80851  9.06549  1.000 187.72870 ? 4   GLN B CG   1 
ATOM 694  C CD   . GLN B 2 3   ? 8.20035   25.07690  10.33376 1.000 183.41664 ? 4   GLN B CD   1 
ATOM 695  O OE1  . GLN B 2 3   ? 7.66047   25.58630  11.31543 1.000 182.09062 ? 4   GLN B OE1  1 
ATOM 696  N NE2  . GLN B 2 3   ? 9.48480   24.74259  10.31671 1.000 173.97990 ? 4   GLN B NE2  1 
ATOM 697  H H    . GLN B 2 3   ? 6.09577   22.01378  8.79244  1.000 196.48077 ? 4   GLN B H    1 
ATOM 698  H HA   . GLN B 2 3   ? 6.07024   23.47171  11.08460 1.000 179.88598 ? 4   GLN B HA   1 
ATOM 699  H HB2  . GLN B 2 3   ? 5.50187   24.41334  8.48196  1.000 216.42637 ? 4   GLN B HB2  1 
ATOM 700  H HB3  . GLN B 2 3   ? 5.57721   25.31855  9.78593  1.000 216.42637 ? 4   GLN B HB3  1 
ATOM 701  H HG2  . GLN B 2 3   ? 7.80241   24.03383  8.62943  1.000 227.82004 ? 4   GLN B HG2  1 
ATOM 702  H HG3  . GLN B 2 3   ? 7.49402   25.58670  8.49194  1.000 227.82004 ? 4   GLN B HG3  1 
ATOM 703  H HE21 . GLN B 2 3   ? 9.82889   24.39336  9.61014  1.000 211.32148 ? 4   GLN B HE21 1 
ATOM 704  H HE22 . GLN B 2 3   ? 9.97291   24.87521  11.01224 1.000 211.32148 ? 4   GLN B HE22 1 
ATOM 705  N N    . LEU B 2 4   ? 3.67050   23.43549  11.53816 1.000 154.65779 ? 5   LEU B N    1 
ATOM 706  C CA   . LEU B 2 4   ? 2.24924   23.32278  11.84526 1.000 177.15147 ? 5   LEU B CA   1 
ATOM 707  C C    . LEU B 2 4   ? 1.77390   24.66572  12.37356 1.000 191.40895 ? 5   LEU B C    1 
ATOM 708  O O    . LEU B 2 4   ? 2.23553   25.11014  13.43019 1.000 192.84741 ? 5   LEU B O    1 
ATOM 709  C CB   . LEU B 2 4   ? 2.00666   22.23078  12.89158 1.000 138.69821 ? 5   LEU B CB   1 
ATOM 710  C CG   . LEU B 2 4   ? 2.54361   20.83772  12.56521 1.000 164.90017 ? 5   LEU B CG   1 
ATOM 711  C CD1  . LEU B 2 4   ? 2.52994   19.96582  13.81084 1.000 173.63199 ? 5   LEU B CD1  1 
ATOM 712  C CD2  . LEU B 2 4   ? 1.72221   20.21258  11.45897 1.000 137.58412 ? 5   LEU B CD2  1 
ATOM 713  H H    . LEU B 2 4   ? 4.13109   23.76177  12.18700 1.000 188.13495 ? 5   LEU B H    1 
ATOM 714  H HA   . LEU B 2 4   ? 1.75146   23.10372  11.04206 1.000 215.12737 ? 5   LEU B HA   1 
ATOM 715  H HB2  . LEU B 2 4   ? 2.42662   22.51060  13.71998 1.000 168.98346 ? 5   LEU B HB2  1 
ATOM 716  H HB3  . LEU B 2 4   ? 1.04885   22.14402  13.01798 1.000 168.98346 ? 5   LEU B HB3  1 
ATOM 717  H HG   . LEU B 2 4   ? 3.46119   20.90424  12.25780 1.000 200.42580 ? 5   LEU B HG   1 
ATOM 718  H HD11 . LEU B 2 4   ? 3.13403   20.34491  14.46831 1.000 210.90400 ? 5   LEU B HD11 1 
ATOM 719  H HD12 . LEU B 2 4   ? 2.81908   19.07095  13.57313 1.000 210.90400 ? 5   LEU B HD12 1 
ATOM 720  H HD13 . LEU B 2 4   ? 1.62819   19.93834  14.16721 1.000 210.90400 ? 5   LEU B HD13 1 
ATOM 721  H HD21 . LEU B 2 4   ? 2.08388   19.33625  11.25370 1.000 167.64654 ? 5   LEU B HD21 1 
ATOM 722  H HD22 . LEU B 2 4   ? 1.76564   20.78055  10.67383 1.000 167.64654 ? 5   LEU B HD22 1 
ATOM 723  H HD23 . LEU B 2 4   ? 0.80277   20.12952  11.75667 1.000 167.64654 ? 5   LEU B HD23 1 
ATOM 724  N N    . GLN B 2 5   ? 0.86196   25.31378  11.64895 1.000 151.30503 ? 6   GLN B N    1 
ATOM 725  C CA   . GLN B 2 5   ? 0.39821   26.65173  12.01183 1.000 192.00950 ? 6   GLN B CA   1 
ATOM 726  C C    . GLN B 2 5   ? -1.11309  26.60116  12.21665 1.000 163.38857 ? 6   GLN B C    1 
ATOM 727  O O    . GLN B 2 5   ? -1.87902  26.63649  11.24680 1.000 188.89808 ? 6   GLN B O    1 
ATOM 728  C CB   . GLN B 2 5   ? 0.78767   27.66236  10.94039 1.000 246.00021 ? 6   GLN B CB   1 
ATOM 729  C CG   . GLN B 2 5   ? 0.59979   29.10813  11.35851 1.000 233.34449 ? 6   GLN B CG   1 
ATOM 730  C CD   . GLN B 2 5   ? 1.63017   29.55259  12.38369 1.000 211.03376 ? 6   GLN B CD   1 
ATOM 731  O OE1  . GLN B 2 5   ? 2.76931   29.08482  12.37918 1.000 152.18075 ? 6   GLN B OE1  1 
ATOM 732  N NE2  . GLN B 2 5   ? 1.23348   30.46095  13.26778 1.000 199.87084 ? 6   GLN B NE2  1 
ATOM 733  H H    . GLN B 2 5   ? 0.49568   24.99604  10.93868 1.000 184.11164 ? 6   GLN B H    1 
ATOM 734  H HA   . GLN B 2 5   ? 0.80302   26.91639  12.85265 1.000 232.95701 ? 6   GLN B HA   1 
ATOM 735  H HB2  . GLN B 2 5   ? 1.72439   27.53784  10.72145 1.000 297.74586 ? 6   GLN B HB2  1 
ATOM 736  H HB3  . GLN B 2 5   ? 0.24006   27.50889  10.15460 1.000 297.74586 ? 6   GLN B HB3  1 
ATOM 737  H HG2  . GLN B 2 5   ? 0.68544   29.67804  10.57828 1.000 282.55899 ? 6   GLN B HG2  1 
ATOM 738  H HG3  . GLN B 2 5   ? -0.28096  29.21328  11.75108 1.000 282.55899 ? 6   GLN B HG3  1 
ATOM 739  H HE21 . GLN B 2 5   ? 0.42980   30.76579  13.23996 1.000 242.39061 ? 6   GLN B HE21 1 
ATOM 740  H HE22 . GLN B 2 5   ? 1.78030   30.74427  13.86804 1.000 242.39061 ? 6   GLN B HE22 1 
ATOM 741  N N    . GLU B 2 6   ? -1.52803  26.47357  13.47718 1.000 171.18756 ? 7   GLU B N    1 
ATOM 742  C CA   . GLU B 2 6   ? -2.93585  26.39002  13.84165 1.000 156.08017 ? 7   GLU B CA   1 
ATOM 743  C C    . GLU B 2 6   ? -3.53951  27.78268  13.99786 1.000 180.57281 ? 7   GLU B C    1 
ATOM 744  O O    . GLU B 2 6   ? -2.89149  28.70313  14.50489 1.000 201.26182 ? 7   GLU B O    1 
ATOM 745  C CB   . GLU B 2 6   ? -3.08634  25.59113  15.13916 1.000 167.98688 ? 7   GLU B CB   1 
ATOM 746  C CG   . GLU B 2 6   ? -2.64131  24.13640  15.00886 1.000 165.21998 ? 7   GLU B CG   1 
ATOM 747  C CD   . GLU B 2 6   ? -1.32924  23.85713  15.72096 1.000 180.03555 ? 7   GLU B CD   1 
ATOM 748  O OE1  . GLU B 2 6   ? -0.55625  24.81147  15.94566 1.000 171.13884 ? 7   GLU B OE1  1 
ATOM 749  O OE2  . GLU B 2 6   ? -1.06389  22.68105  16.04274 1.000 154.99959 ? 7   GLU B OE2  1 
ATOM 750  H H    . GLU B 2 6   ? -0.99821  26.43239  14.15334 1.000 207.97067 ? 7   GLU B H    1 
ATOM 751  H HA   . GLU B 2 6   ? -3.43111  25.93941  13.13981 1.000 189.84181 ? 7   GLU B HA   1 
ATOM 752  H HB2  . GLU B 2 6   ? -2.54535  26.00761  15.82819 1.000 204.12986 ? 7   GLU B HB2  1 
ATOM 753  H HB3  . GLU B 2 6   ? -4.01979  25.59464  15.40290 1.000 204.12986 ? 7   GLU B HB3  1 
ATOM 754  H HG2  . GLU B 2 6   ? -3.32064  23.56219  15.39575 1.000 200.80958 ? 7   GLU B HG2  1 
ATOM 755  H HG3  . GLU B 2 6   ? -2.52369  23.92479  14.06955 1.000 200.80958 ? 7   GLU B HG3  1 
ATOM 756  N N    . SER B 2 7   ? -4.78282  27.92959  13.54369 1.000 168.54754 ? 8   SER B N    1 
ATOM 757  C CA   . SER B 2 7   ? -5.52180  29.17847  13.66017 1.000 171.40714 ? 8   SER B CA   1 
ATOM 758  C C    . SER B 2 7   ? -7.01439  28.87534  13.68786 1.000 194.70971 ? 8   SER B C    1 
ATOM 759  O O    . SER B 2 7   ? -7.44516  27.74222  13.46354 1.000 182.82722 ? 8   SER B O    1 
ATOM 760  C CB   . SER B 2 7   ? -5.18760  30.13208  12.50886 1.000 195.97194 ? 8   SER B CB   1 
ATOM 761  O OG   . SER B 2 7   ? -5.65592  29.62267  11.27124 1.000 179.15159 ? 8   SER B OG   1 
ATOM 762  H H    . SER B 2 7   ? -5.22818  27.30460  13.15557 1.000 204.80265 ? 8   SER B H    1 
ATOM 763  H HA   . SER B 2 7   ? -5.28395  29.60699  14.49725 1.000 208.23417 ? 8   SER B HA   1 
ATOM 764  H HB2  . SER B 2 7   ? -5.61065  30.98864  12.67688 1.000 237.71193 ? 8   SER B HB2  1 
ATOM 765  H HB3  . SER B 2 7   ? -4.22501  30.24136  12.46013 1.000 237.71193 ? 8   SER B HB3  1 
ATOM 766  H HG   . SER B 2 7   ? -6.37862  29.99612  11.06185 1.000 217.52751 ? 8   SER B HG   1 
ATOM 767  N N    . GLY B 2 8   ? -7.80438  29.91540  13.95537 1.000 188.42191 ? 9   GLY B N    1 
ATOM 768  C CA   . GLY B 2 8   ? -9.24883  29.84815  13.88696 1.000 155.53254 ? 9   GLY B CA   1 
ATOM 769  C C    . GLY B 2 8   ? -9.93438  29.69655  15.22663 1.000 162.68540 ? 9   GLY B C    1 
ATOM 770  O O    . GLY B 2 8   ? -11.16737 29.76874  15.28641 1.000 140.79212 ? 9   GLY B O    1 
ATOM 771  H H    . GLY B 2 8   ? -7.51096  30.69053  14.18489 1.000 228.65189 ? 9   GLY B H    1 
ATOM 772  H HA2  . GLY B 2 8   ? -9.57979  30.66109  13.47405 1.000 189.18465 ? 9   GLY B HA2  1 
ATOM 773  H HA3  . GLY B 2 8   ? -9.50014  29.08968  13.33699 1.000 189.18465 ? 9   GLY B HA3  1 
ATOM 774  N N    . GLY B 2 9   ? -9.17462  29.50056  16.29536 1.000 169.82895 ? 10  GLY B N    1 
ATOM 775  C CA   . GLY B 2 9   ? -9.70735  29.53869  17.63739 1.000 159.39357 ? 10  GLY B CA   1 
ATOM 776  C C    . GLY B 2 9   ? -10.10530 30.94193  18.05010 1.000 142.70674 ? 10  GLY B C    1 
ATOM 777  O O    . GLY B 2 9   ? -9.98671  31.91485  17.30425 1.000 168.78805 ? 10  GLY B O    1 
ATOM 778  H H    . GLY B 2 9   ? -8.33021  29.34063  16.26384 1.000 206.34034 ? 10  GLY B H    1 
ATOM 779  H HA2  . GLY B 2 9   ? -10.49071 28.96905  17.68993 1.000 193.81788 ? 10  GLY B HA2  1 
ATOM 780  H HA3  . GLY B 2 9   ? -9.03807  29.21345  18.25962 1.000 193.81788 ? 10  GLY B HA3  1 
ATOM 781  N N    . GLY B 2 10  ? -10.60202 31.03669  19.27622 1.000 146.56797 ? 11  GLY B N    1 
ATOM 782  C CA   . GLY B 2 10  ? -11.04293 32.31093  19.80943 1.000 206.32272 ? 11  GLY B CA   1 
ATOM 783  C C    . GLY B 2 10  ? -12.03250 32.10291  20.94256 1.000 198.88130 ? 11  GLY B C    1 
ATOM 784  O O    . GLY B 2 10  ? -12.09174 31.03209  21.54215 1.000 168.65001 ? 11  GLY B O    1 
ATOM 785  H H    . GLY B 2 10  ? -10.69345 30.37548  19.81847 1.000 178.42716 ? 11  GLY B H    1 
ATOM 786  H HA2  . GLY B 2 10  ? -10.28089 32.80713  20.14705 1.000 250.13286 ? 11  GLY B HA2  1 
ATOM 787  H HA3  . GLY B 2 10  ? -11.47233 32.82862  19.11049 1.000 250.13286 ? 11  GLY B HA3  1 
ATOM 788  N N    . LEU B 2 11  ? -12.82144 33.14429  21.19144 1.000 198.45444 ? 12  LEU B N    1 
ATOM 789  C CA   . LEU B 2 11  ? -13.88239 33.11339  22.18886 1.000 182.33020 ? 12  LEU B CA   1 
ATOM 790  C C    . LEU B 2 11  ? -15.23578 33.00511  21.50457 1.000 161.30575 ? 12  LEU B C    1 
ATOM 791  O O    . LEU B 2 11  ? -15.57806 33.83368  20.65454 1.000 180.75297 ? 12  LEU B O    1 
ATOM 792  C CB   . LEU B 2 11  ? -13.83053 34.36874  23.05930 1.000 170.78700 ? 12  LEU B CB   1 
ATOM 793  C CG   . LEU B 2 11  ? -14.91584 34.50533  24.12915 1.000 183.34574 ? 12  LEU B CG   1 
ATOM 794  C CD1  . LEU B 2 11  ? -14.78642 33.43699  25.19961 1.000 149.86007 ? 12  LEU B CD1  1 
ATOM 795  C CD2  . LEU B 2 11  ? -14.85318 35.89364  24.74068 1.000 192.30708 ? 12  LEU B CD2  1 
ATOM 796  H H    . LEU B 2 11  ? -12.75847 33.89887  20.78371 1.000 240.69093 ? 12  LEU B H    1 
ATOM 797  H HA   . LEU B 2 11  ? -13.76715 32.32985  22.74894 1.000 221.34184 ? 12  LEU B HA   1 
ATOM 798  H HB2  . LEU B 2 11  ? -12.97576 34.38100  23.51769 1.000 207.49000 ? 12  LEU B HB2  1 
ATOM 799  H HB3  . LEU B 2 11  ? -13.90588 35.14093  22.47712 1.000 207.49000 ? 12  LEU B HB3  1 
ATOM 800  H HG   . LEU B 2 11  ? -15.78435 34.38134  23.71537 1.000 222.56049 ? 12  LEU B HG   1 
ATOM 801  H HD11 . LEU B 2 11  ? -15.42517 33.61923  25.90650 1.000 182.37768 ? 12  LEU B HD11 1 
ATOM 802  H HD12 . LEU B 2 11  ? -13.88449 33.45477  25.55611 1.000 182.37768 ? 12  LEU B HD12 1 
ATOM 803  H HD13 . LEU B 2 11  ? -14.96884 32.57016  24.80435 1.000 182.37768 ? 12  LEU B HD13 1 
ATOM 804  H HD21 . LEU B 2 11  ? -15.55045 35.97565  25.41000 1.000 233.31410 ? 12  LEU B HD21 1 
ATOM 805  H HD22 . LEU B 2 11  ? -13.98359 36.01864  25.15188 1.000 233.31410 ? 12  LEU B HD22 1 
ATOM 806  H HD23 . LEU B 2 11  ? -14.98642 36.55290  24.04173 1.000 233.31410 ? 12  LEU B HD23 1 
ATOM 807  N N    . VAL B 2 12  ? -15.99939 31.98448  21.88533 1.000 166.53250 ? 13  VAL B N    1 
ATOM 808  C CA   . VAL B 2 12  ? -17.25725 31.65490  21.23233 1.000 177.76527 ? 13  VAL B CA   1 
ATOM 809  C C    . VAL B 2 12  ? -18.28756 31.35541  22.31423 1.000 164.18052 ? 13  VAL B C    1 
ATOM 810  O O    . VAL B 2 12  ? -17.95579 30.86889  23.40148 1.000 175.22531 ? 13  VAL B O    1 
ATOM 811  C CB   . VAL B 2 12  ? -17.08889 30.47837  20.23918 1.000 152.76774 ? 13  VAL B CB   1 
ATOM 812  C CG1  . VAL B 2 12  ? -16.86402 29.17026  20.97286 1.000 151.02949 ? 13  VAL B CG1  1 
ATOM 813  C CG2  . VAL B 2 12  ? -18.28168 30.38519  19.29607 1.000 144.19943 ? 13  VAL B CG2  1 
ATOM 814  H H    . VAL B 2 12  ? -15.80309 31.45697  22.53556 1.000 202.38460 ? 13  VAL B H    1 
ATOM 815  H HA   . VAL B 2 12  ? -17.58416 32.41336  20.72365 1.000 215.86393 ? 13  VAL B HA   1 
ATOM 816  H HB   . VAL B 2 12  ? -16.30106 30.64660  19.69888 1.000 185.86689 ? 13  VAL B HB   1 
ATOM 817  H HG11 . VAL B 2 12  ? -16.63119 28.48307  20.32907 1.000 183.78099 ? 13  VAL B HG11 1 
ATOM 818  H HG12 . VAL B 2 12  ? -17.67900 28.92505  21.43824 1.000 183.78099 ? 13  VAL B HG12 1 
ATOM 819  H HG13 . VAL B 2 12  ? -16.14139 29.28548  21.60960 1.000 183.78099 ? 13  VAL B HG13 1 
ATOM 820  H HG21 . VAL B 2 12  ? -18.10755 29.69842  18.63356 1.000 175.58492 ? 13  VAL B HG21 1 
ATOM 821  H HG22 . VAL B 2 12  ? -18.40653 31.24219  18.85918 1.000 175.58492 ? 13  VAL B HG22 1 
ATOM 822  H HG23 . VAL B 2 12  ? -19.07274 30.15703  19.80897 1.000 175.58492 ? 13  VAL B HG23 1 
ATOM 823  N N    . GLN B 2 13  ? -19.54318 31.67137  22.01715 1.000 159.64505 ? 14  GLN B N    1 
ATOM 824  C CA   . GLN B 2 13  ? -20.63514 31.33032  22.91344 1.000 177.87771 ? 14  GLN B CA   1 
ATOM 825  C C    . GLN B 2 13  ? -21.01712 29.86498  22.75695 1.000 172.40008 ? 14  GLN B C    1 
ATOM 826  O O    . GLN B 2 13  ? -20.84141 29.26591  21.69408 1.000 189.86244 ? 14  GLN B O    1 
ATOM 827  C CB   . GLN B 2 13  ? -21.85321 32.21218  22.63354 1.000 199.21810 ? 14  GLN B CB   1 
ATOM 828  C CG   . GLN B 2 13  ? -21.64969 33.68700  22.95000 1.000 239.66372 ? 14  GLN B CG   1 
ATOM 829  C CD   . GLN B 2 13  ? -21.11758 33.91717  24.35109 1.000 250.30842 ? 14  GLN B CD   1 
ATOM 830  O OE1  . GLN B 2 13  ? -21.83559 33.73907  25.33545 1.000 234.78692 ? 14  GLN B OE1  1 
ATOM 831  N NE2  . GLN B 2 13  ? -19.85161 34.30460  24.44912 1.000 244.61660 ? 14  GLN B NE2  1 
ATOM 832  H H    . GLN B 2 13  ? -19.78677 32.08309  21.30249 1.000 194.11967 ? 14  GLN B H    1 
ATOM 833  H HA   . GLN B 2 13  ? -20.35689 31.47825  23.83083 1.000 215.99886 ? 14  GLN B HA   1 
ATOM 834  H HB2  . GLN B 2 13  ? -22.07547 32.14238  21.69193 1.000 241.60732 ? 14  GLN B HB2  1 
ATOM 835  H HB3  . GLN B 2 13  ? -22.59430 31.89603  23.17367 1.000 241.60732 ? 14  GLN B HB3  1 
ATOM 836  H HG2  . GLN B 2 13  ? -21.01187 34.06020  22.32167 1.000 290.14206 ? 14  GLN B HG2  1 
ATOM 837  H HG3  . GLN B 2 13  ? -22.49996 34.14736  22.87249 1.000 290.14206 ? 14  GLN B HG3  1 
ATOM 838  H HE21 . GLN B 2 13  ? -19.37868 34.41236  23.73896 1.000 296.08553 ? 14  GLN B HE21 1 
ATOM 839  H HE22 . GLN B 2 13  ? -19.50443 34.44782  25.22279 1.000 296.08553 ? 14  GLN B HE22 1 
ATOM 840  N N    . ALA B 2 14  ? -21.49411 29.27660  23.85223 1.000 173.87081 ? 15  ALA B N    1 
ATOM 841  C CA   . ALA B 2 14  ? -22.06893 27.94082  23.80325 1.000 120.20130 ? 15  ALA B CA   1 
ATOM 842  C C    . ALA B 2 14  ? -23.15237 27.86745  22.73426 1.000 176.55747 ? 15  ALA B C    1 
ATOM 843  O O    . ALA B 2 14  ? -23.94105 28.80033  22.56032 1.000 247.67645 ? 15  ALA B O    1 
ATOM 844  C CB   . ALA B 2 14  ? -22.63789 27.56565  25.17314 1.000 124.17183 ? 15  ALA B CB   1 
ATOM 845  H H    . ALA B 2 14  ? -21.49553 29.63192  24.63539 1.000 211.19057 ? 15  ALA B H    1 
ATOM 846  H HA   . ALA B 2 14  ? -21.37999 27.29592  23.57880 1.000 146.78717 ? 15  ALA B HA   1 
ATOM 847  H HB1  . ALA B 2 14  ? -21.93637 27.64340  25.83852 1.000 151.55180 ? 15  ALA B HB1  1 
ATOM 848  H HB2  . ALA B 2 14  ? -23.36637 28.16884  25.38850 1.000 151.55180 ? 15  ALA B HB2  1 
ATOM 849  H HB3  . ALA B 2 14  ? -22.96322 26.65241  25.14064 1.000 151.55180 ? 15  ALA B HB3  1 
ATOM 850  N N    . GLY B 2 15  ? -23.18437 26.74505  22.01670 1.000 157.49771 ? 16  GLY B N    1 
ATOM 851  C CA   . GLY B 2 15  ? -24.00889 26.59400  20.83818 1.000 184.92819 ? 16  GLY B CA   1 
ATOM 852  C C    . GLY B 2 15  ? -23.42986 27.19458  19.57869 1.000 167.37959 ? 16  GLY B C    1 
ATOM 853  O O    . GLY B 2 15  ? -23.95891 26.93906  18.48980 1.000 200.73375 ? 16  GLY B O    1 
ATOM 854  H H    . GLY B 2 15  ? -22.72297 26.04371  22.20334 1.000 191.54285 ? 16  GLY B H    1 
ATOM 855  H HA2  . GLY B 2 15  ? -24.15059 25.64800  20.67719 1.000 224.45943 ? 16  GLY B HA2  1 
ATOM 856  H HA3  . GLY B 2 15  ? -24.86567 27.01830  21.00186 1.000 224.45943 ? 16  GLY B HA3  1 
ATOM 857  N N    . GLY B 2 16  ? -22.35733 27.97356  19.68688 1.000 152.96437 ? 17  GLY B N    1 
ATOM 858  C CA   . GLY B 2 16  ? -21.68330 28.52931  18.53556 1.000 193.81802 ? 17  GLY B CA   1 
ATOM 859  C C    . GLY B 2 16  ? -20.84362 27.51492  17.78650 1.000 187.45002 ? 17  GLY B C    1 
ATOM 860  O O    . GLY B 2 16  ? -20.74532 26.34073  18.14233 1.000 154.58976 ? 17  GLY B O    1 
ATOM 861  H H    . GLY B 2 16  ? -21.99791 28.19592  20.43586 1.000 186.10285 ? 17  GLY B H    1 
ATOM 862  H HA2  . GLY B 2 16  ? -22.34449 28.88607  17.92200 1.000 235.12723 ? 17  GLY B HA2  1 
ATOM 863  H HA3  . GLY B 2 16  ? -21.10065 29.24870  18.82523 1.000 235.12723 ? 17  GLY B HA3  1 
ATOM 864  N N    . SER B 2 17  ? -20.23445 27.99622  16.70567 1.000 208.05913 ? 18  SER B N    1 
ATOM 865  C CA   . SER B 2 17  ? -19.42567 27.17784  15.81688 1.000 172.29208 ? 18  SER B CA   1 
ATOM 866  C C    . SER B 2 17  ? -18.06092 27.82486  15.62196 1.000 183.98968 ? 18  SER B C    1 
ATOM 867  O O    . SER B 2 17  ? -17.91975 29.04866  15.69113 1.000 142.06541 ? 18  SER B O    1 
ATOM 868  C CB   . SER B 2 17  ? -20.11273 26.96782  14.46326 1.000 167.02472 ? 18  SER B CB   1 
ATOM 869  O OG   . SER B 2 17  ? -21.26460 26.15145  14.59785 1.000 155.02410 ? 18  SER B OG   1 
ATOM 870  H H    . SER B 2 17  ? -20.27813 28.81971  16.46161 1.000 252.21656 ? 18  SER B H    1 
ATOM 871  H HA   . SER B 2 17  ? -19.28535 26.30553  16.21722 1.000 209.29610 ? 18  SER B HA   1 
ATOM 872  H HB2  . SER B 2 17  ? -20.37788 27.83038  14.10747 1.000 202.97527 ? 18  SER B HB2  1 
ATOM 873  H HB3  . SER B 2 17  ? -19.48995 26.53633  13.85757 1.000 202.97527 ? 18  SER B HB3  1 
ATOM 874  H HG   . SER B 2 17  ? -21.13262 25.40610  14.23367 1.000 188.57452 ? 18  SER B HG   1 
ATOM 875  N N    . LEU B 2 18  ? -17.05594 26.98561  15.38165 1.000 196.04933 ? 19  LEU B N    1 
ATOM 876  C CA   . LEU B 2 18  ? -15.74245 27.42840  14.93647 1.000 190.39011 ? 19  LEU B CA   1 
ATOM 877  C C    . LEU B 2 18  ? -15.29722 26.55682  13.77124 1.000 186.96806 ? 19  LEU B C    1 
ATOM 878  O O    . LEU B 2 18  ? -15.80029 25.45178  13.57295 1.000 172.60076 ? 19  LEU B O    1 
ATOM 879  C CB   . LEU B 2 18  ? -14.70529 27.33588  16.06771 1.000 137.40091 ? 19  LEU B CB   1 
ATOM 880  C CG   . LEU B 2 18  ? -14.85505 28.26565  17.27284 1.000 159.37854 ? 19  LEU B CG   1 
ATOM 881  C CD1  . LEU B 2 18  ? -13.82325 27.91462  18.33698 1.000 170.27390 ? 19  LEU B CD1  1 
ATOM 882  C CD2  . LEU B 2 18  ? -14.69597 29.71857  16.85377 1.000 183.85573 ? 19  LEU B CD2  1 
ATOM 883  H H    . LEU B 2 18  ? -17.11471 26.13245  15.47252 1.000 237.80480 ? 19  LEU B H    1 
ATOM 884  H HA   . LEU B 2 18  ? -15.79278 28.35063  14.64006 1.000 231.01373 ? 19  LEU B HA   1 
ATOM 885  H HB2  . LEU B 2 18  ? -14.72917 26.42976  16.41309 1.000 167.42670 ? 19  LEU B HB2  1 
ATOM 886  H HB3  . LEU B 2 18  ? -13.83466 27.52115  15.68224 1.000 167.42670 ? 19  LEU B HB3  1 
ATOM 887  H HG   . LEU B 2 18  ? -15.74234 28.15385  17.64851 1.000 193.79986 ? 19  LEU B HG   1 
ATOM 888  H HD11 . LEU B 2 18  ? -13.95094 26.99221  18.60856 1.000 206.87428 ? 19  LEU B HD11 1 
ATOM 889  H HD12 . LEU B 2 18  ? -12.93466 28.03010  17.96553 1.000 206.87428 ? 19  LEU B HD12 1 
ATOM 890  H HD13 . LEU B 2 18  ? -13.94240 28.50323  19.09872 1.000 206.87428 ? 19  LEU B HD13 1 
ATOM 891  H HD21 . LEU B 2 18  ? -15.41270 29.95137  16.24303 1.000 223.17248 ? 19  LEU B HD21 1 
ATOM 892  H HD22 . LEU B 2 18  ? -13.83821 29.82839  16.41435 1.000 223.17248 ? 19  LEU B HD22 1 
ATOM 893  H HD23 . LEU B 2 18  ? -14.73787 30.28123  17.64279 1.000 223.17248 ? 19  LEU B HD23 1 
ATOM 894  N N    . ARG B 2 19  ? -14.37769 27.07701  12.96360 1.000 150.70425 ? 20  ARG B N    1 
ATOM 895  C CA   . ARG B 2 19  ? -13.65078 26.25995  11.99584 1.000 168.20270 ? 20  ARG B CA   1 
ATOM 896  C C    . ARG B 2 19  ? -12.16046 26.48711  12.21881 1.000 191.16391 ? 20  ARG B C    1 
ATOM 897  O O    . ARG B 2 19  ? -11.63027 27.54217  11.85397 1.000 201.53399 ? 20  ARG B O    1 
ATOM 898  C CB   . ARG B 2 19  ? -14.08503 26.59689  10.56823 1.000 171.21449 ? 20  ARG B CB   1 
ATOM 899  C CG   . ARG B 2 19  ? -13.49003 25.71534  9.48270  1.000 157.98814 ? 20  ARG B CG   1 
ATOM 900  C CD   . ARG B 2 19  ? -14.04979 26.10537  8.12166  1.000 165.49662 ? 20  ARG B CD   1 
ATOM 901  N NE   . ARG B 2 19  ? -13.08357 25.97412  7.03639  1.000 157.19003 ? 20  ARG B NE   1 
ATOM 902  C CZ   . ARG B 2 19  ? -13.14485 25.06530  6.07016  1.000 213.13138 ? 20  ARG B CZ   1 
ATOM 903  N NH1  . ARG B 2 19  ? -14.07263 24.11888  6.05946  1.000 234.85789 ? 20  ARG B NH1  1 
ATOM 904  N NH2  . ARG B 2 19  ? -12.24477 25.09981  5.09161  1.000 229.25267 ? 20  ARG B NH2  1 
ATOM 905  H H    . ARG B 2 19  ? -14.15550 27.90779  12.95746 1.000 183.39070 ? 20  ARG B H    1 
ATOM 906  H HA   . ARG B 2 19  ? -13.82906 25.31775  12.14203 1.000 204.38884 ? 20  ARG B HA   1 
ATOM 907  H HB2  . ARG B 2 19  ? -15.04975 26.51155  10.51396 1.000 208.00299 ? 20  ARG B HB2  1 
ATOM 908  H HB3  . ARG B 2 19  ? -13.82145 27.51039  10.37607 1.000 208.00299 ? 20  ARG B HB3  1 
ATOM 909  H HG2  . ARG B 2 19  ? -12.52647 25.82550  9.46489  1.000 192.13137 ? 20  ARG B HG2  1 
ATOM 910  H HG3  . ARG B 2 19  ? -13.71476 24.78783  9.65624  1.000 192.13137 ? 20  ARG B HG3  1 
ATOM 911  H HD2  . ARG B 2 19  ? -14.80511 25.53209  7.91735  1.000 201.14155 ? 20  ARG B HD2  1 
ATOM 912  H HD3  . ARG B 2 19  ? -14.33559 27.03174  8.15399  1.000 201.14155 ? 20  ARG B HD3  1 
ATOM 913  H HE   . ARG B 2 19  ? -12.42489 26.52684  7.02132  1.000 191.17363 ? 20  ARG B HE   1 
ATOM 914  H HH11 . ARG B 2 19  ? -14.65640 24.08186  6.68989  1.000 284.37507 ? 20  ARG B HH11 1 
ATOM 915  H HH12 . ARG B 2 19  ? -14.09087 23.54180  5.42210  1.000 284.37507 ? 20  ARG B HH12 1 
ATOM 916  H HH21 . ARG B 2 19  ? -11.63386 25.70511  5.09044  1.000 277.64881 ? 20  ARG B HH21 1 
ATOM 917  H HH22 . ARG B 2 19  ? -12.27367 24.51683  4.46003  1.000 277.64881 ? 20  ARG B HH22 1 
ATOM 918  N N    . LEU B 2 20  ? -11.48498 25.50186  12.80892 1.000 201.42578 ? 21  LEU B N    1 
ATOM 919  C CA   . LEU B 2 20  ? -10.03952 25.56381  12.96372 1.000 197.80193 ? 21  LEU B CA   1 
ATOM 920  C C    . LEU B 2 20  ? -9.33467  25.18340  11.66800 1.000 176.46661 ? 21  LEU B C    1 
ATOM 921  O O    . LEU B 2 20  ? -9.80405  24.33248  10.90726 1.000 148.10499 ? 21  LEU B O    1 
ATOM 922  C CB   . LEU B 2 20  ? -9.58006  24.62258  14.07821 1.000 168.21197 ? 21  LEU B CB   1 
ATOM 923  C CG   . LEU B 2 20  ? -10.32804 24.67872  15.41119 1.000 170.30541 ? 21  LEU B CG   1 
ATOM 924  C CD1  . LEU B 2 20  ? -9.64283  23.79194  16.43685 1.000 167.29243 ? 21  LEU B CD1  1 
ATOM 925  C CD2  . LEU B 2 20  ? -10.44069 26.10177  15.92410 1.000 191.71791 ? 21  LEU B CD2  1 
ATOM 926  H H    . LEU B 2 20  ? -11.84360 24.78791  13.12714 1.000 244.25654 ? 21  LEU B H    1 
ATOM 927  H HA   . LEU B 2 20  ? -9.78696  26.47108  13.19608 1.000 239.90792 ? 21  LEU B HA   1 
ATOM 928  H HB2  . LEU B 2 20  ? -9.66186  23.71356  13.74974 1.000 204.39997 ? 21  LEU B HB2  1 
ATOM 929  H HB3  . LEU B 2 20  ? -8.65077  24.82354  14.27034 1.000 204.39997 ? 21  LEU B HB3  1 
ATOM 930  H HG   . LEU B 2 20  ? -11.23018 24.34995  15.27349 1.000 206.91210 ? 21  LEU B HG   1 
ATOM 931  H HD11 . LEU B 2 20  ? -10.13853 23.83118  17.26970 1.000 203.29652 ? 21  LEU B HD11 1 
ATOM 932  H HD12 . LEU B 2 20  ? -8.73735  24.11096  16.57550 1.000 203.29652 ? 21  LEU B HD12 1 
ATOM 933  H HD13 . LEU B 2 20  ? -9.62529  22.88064  16.10498 1.000 203.29652 ? 21  LEU B HD13 1 
ATOM 934  H HD21 . LEU B 2 20  ? -10.95570 26.62586  15.29087 1.000 232.60710 ? 21  LEU B HD21 1 
ATOM 935  H HD22 . LEU B 2 20  ? -10.88632 26.09258  16.78563 1.000 232.60710 ? 21  LEU B HD22 1 
ATOM 936  H HD23 . LEU B 2 20  ? -9.55040  26.47567  16.01618 1.000 232.60710 ? 21  LEU B HD23 1 
ATOM 937  N N    . SER B 2 21  ? -8.15608  25.77606  11.47140 1.000 195.70550 ? 22  SER B N    1 
ATOM 938  C CA   . SER B 2 21  ? -7.25553  25.49874  10.36111 1.000 186.11196 ? 22  SER B CA   1 
ATOM 939  C C    . SER B 2 21  ? -5.87383  25.15864  10.90006 1.000 177.39571 ? 22  SER B C    1 
ATOM 940  O O    . SER B 2 21  ? -5.44218  25.71923  11.90640 1.000 198.04075 ? 22  SER B O    1 
ATOM 941  C CB   . SER B 2 21  ? -7.14751  26.70185  9.41743  1.000 166.76364 ? 22  SER B CB   1 
ATOM 942  O OG   . SER B 2 21  ? -8.36393  26.93931  8.73313  1.000 199.93746 ? 22  SER B OG   1 
ATOM 943  H H    . SER B 2 21  ? -7.84141  26.37659  12.00049 1.000 237.39221 ? 22  SER B H    1 
ATOM 944  H HA   . SER B 2 21  ? -7.58986  24.73898  9.85923  1.000 225.87996 ? 22  SER B HA   1 
ATOM 945  H HB2  . SER B 2 21  ? -6.92321  27.48867  9.93848  1.000 202.66197 ? 22  SER B HB2  1 
ATOM 946  H HB3  . SER B 2 21  ? -6.45119  26.52615  8.76538  1.000 202.66197 ? 22  SER B HB3  1 
ATOM 947  H HG   . SER B 2 21  ? -8.43477  27.75557  8.54793  1.000 242.47055 ? 22  SER B HG   1 
ATOM 948  N N    . CYS B 2 22  ? -5.20009  24.21389  10.25265 1.000 159.64030 ? 23  CYS B N    1 
ATOM 949  C CA   . CYS B 2 22  ? -3.77185  23.98108  10.44027 1.000 186.13771 ? 23  CYS B CA   1 
ATOM 950  C C    . CYS B 2 22  ? -3.09696  23.98964  9.07949  1.000 180.44225 ? 23  CYS B C    1 
ATOM 951  O O    . CYS B 2 22  ? -3.34226  23.10018  8.25495  1.000 143.29696 ? 23  CYS B O    1 
ATOM 952  C CB   . CYS B 2 22  ? -3.48806  22.66369  11.15128 1.000 162.58347 ? 23  CYS B CB   1 
ATOM 953  S SG   . CYS B 2 22  ? -1.71334  22.45157  11.45159 1.000 168.98840 ? 23  CYS B SG   1 
ATOM 954  H H    . CYS B 2 22  ? -5.55899  23.67920  9.68266  1.000 194.11397 ? 23  CYS B H    1 
ATOM 955  H HA   . CYS B 2 22  ? -3.41716  24.70422  10.98079 1.000 225.91085 ? 23  CYS B HA   1 
ATOM 956  H HB2  . CYS B 2 22  ? -3.94754  22.65363  12.00549 1.000 197.64577 ? 23  CYS B HB2  1 
ATOM 957  H HB3  . CYS B 2 22  ? -3.79649  21.92760  10.59997 1.000 197.64577 ? 23  CYS B HB3  1 
ATOM 958  H HG   . CYS B 2 22  ? -1.47806  21.28351  11.59394 1.000 205.33169 ? 23  CYS B HG   1 
ATOM 959  N N    . ALA B 2 23  ? -2.28181  25.01297  8.84069  1.000 184.60852 ? 24  ALA B N    1 
ATOM 960  C CA   . ALA B 2 23  ? -1.46500  25.08226  7.63761  1.000 160.53669 ? 24  ALA B CA   1 
ATOM 961  C C    . ALA B 2 23  ? -0.16801  24.30835  7.85141  1.000 165.93461 ? 24  ALA B C    1 
ATOM 962  O O    . ALA B 2 23  ? 0.57923   24.57975  8.80115  1.000 187.66240 ? 24  ALA B O    1 
ATOM 963  C CB   . ALA B 2 23  ? -1.17707  26.53562  7.27244  1.000 185.93414 ? 24  ALA B CB   1 
ATOM 964  H H    . ALA B 2 23  ? -2.18400  25.68616  9.36685  1.000 224.07583 ? 24  ALA B H    1 
ATOM 965  H HA   . ALA B 2 23  ? -1.94473  24.67419  6.89989  1.000 195.18964 ? 24  ALA B HA   1 
ATOM 966  H HB1  . ALA B 2 23  ? -2.01787  26.99842  7.13179  1.000 225.66657 ? 24  ALA B HB1  1 
ATOM 967  H HB2  . ALA B 2 23  ? -0.64719  26.55815  6.46027  1.000 225.66657 ? 24  ALA B HB2  1 
ATOM 968  H HB3  . ALA B 2 23  ? -0.68740  26.95262  7.99854  1.000 225.66657 ? 24  ALA B HB3  1 
ATOM 969  N N    . VAL B 2 24  ? 0.05955   23.30893  7.00185  1.000 178.64693 ? 25  VAL B N    1 
ATOM 970  C CA   . VAL B 2 24  ? 1.13135   22.33267  7.15825  1.000 166.29999 ? 25  VAL B CA   1 
ATOM 971  C C    . VAL B 2 24  ? 2.20480   22.62146  6.11868  1.000 166.64412 ? 25  VAL B C    1 
ATOM 972  O O    . VAL B 2 24  ? 1.89303   22.98253  4.97811  1.000 170.86369 ? 25  VAL B O    1 
ATOM 973  C CB   . VAL B 2 24  ? 0.60971   20.88921  7.01934  1.000 155.74105 ? 25  VAL B CB   1 
ATOM 974  C CG1  . VAL B 2 24  ? 1.72540   19.88862  7.30505  1.000 154.33530 ? 25  VAL B CG1  1 
ATOM 975  C CG2  . VAL B 2 24  ? -0.57516  20.66115  7.94596  1.000 198.80960 ? 25  VAL B CG2  1 
ATOM 976  H H    . VAL B 2 24  ? -0.41492  23.17151  6.29786  1.000 216.92192 ? 25  VAL B H    1 
ATOM 977  H HA   . VAL B 2 24  ? 1.52204   22.42932  8.04082  1.000 202.10559 ? 25  VAL B HA   1 
ATOM 978  H HB   . VAL B 2 24  ? 0.30847   20.74819  6.10815  1.000 189.43486 ? 25  VAL B HB   1 
ATOM 979  H HG11 . VAL B 2 24  ? 2.42370   19.99595  6.64040  1.000 187.74797 ? 25  VAL B HG11 1 
ATOM 980  H HG12 . VAL B 2 24  ? 1.36256   18.99009  7.26148  1.000 187.74797 ? 25  VAL B HG12 1 
ATOM 981  H HG13 . VAL B 2 24  ? 2.08276   20.05846  8.19068  1.000 187.74797 ? 25  VAL B HG13 1 
ATOM 982  H HG21 . VAL B 2 24  ? -1.28514  21.27791  7.70840  1.000 241.11712 ? 25  VAL B HG21 1 
ATOM 983  H HG22 . VAL B 2 24  ? -0.29461  20.81649  8.86142  1.000 241.11712 ? 25  VAL B HG22 1 
ATOM 984  H HG23 . VAL B 2 24  ? -0.88358  19.74704  7.84510  1.000 241.11712 ? 25  VAL B HG23 1 
ATOM 985  N N    . SER B 2 25  ? 3.46815   22.49799  6.51846  1.000 172.56768 ? 26  SER B N    1 
ATOM 986  C CA   . SER B 2 25  ? 4.57221   22.48300  5.56725  1.000 151.59651 ? 26  SER B CA   1 
ATOM 987  C C    . SER B 2 25  ? 5.51516   21.32803  5.87849  1.000 161.69560 ? 26  SER B C    1 
ATOM 988  O O    . SER B 2 25  ? 5.69339   20.94354  7.03796  1.000 181.63589 ? 26  SER B O    1 
ATOM 989  C CB   . SER B 2 25  ? 5.35966   23.80769  5.57170  1.000 113.66417 ? 26  SER B CB   1 
ATOM 990  O OG   . SER B 2 25  ? 4.49228   24.92764  5.62013  1.000 192.07414 ? 26  SER B OG   1 
ATOM 991  H H    . SER B 2 25  ? 3.71041   22.42110  7.34004  1.000 209.62682 ? 26  SER B H    1 
ATOM 992  H HA   . SER B 2 25  ? 4.21271   22.34952  4.67627  1.000 184.46142 ? 26  SER B HA   1 
ATOM 993  H HB2  . SER B 2 25  ? 5.93789   23.82560  6.35030  1.000 138.94261 ? 26  SER B HB2  1 
ATOM 994  H HB3  . SER B 2 25  ? 5.89162   23.85844  4.76216  1.000 138.94261 ? 26  SER B HB3  1 
ATOM 995  H HG   . SER B 2 25  ? 4.94021   25.63824  5.61780  1.000 233.03457 ? 26  SER B HG   1 
ATOM 996  N N    . GLY B 2 26  ? 6.13238   20.78796  4.82346  1.000 137.37799 ? 27  GLY B N    1 
ATOM 997  C CA   . GLY B 2 26  ? 7.10511   19.72490  4.94759  1.000 155.48518 ? 27  GLY B CA   1 
ATOM 998  C C    . GLY B 2 26  ? 6.56298   18.31499  4.80989  1.000 178.55482 ? 27  GLY B C    1 
ATOM 999  O O    . GLY B 2 26  ? 7.35094   17.38837  4.59381  1.000 165.21075 ? 27  GLY B O    1 
ATOM 1000 H H    . GLY B 2 26  ? 5.99438   21.03308  4.01077  1.000 167.39919 ? 27  GLY B H    1 
ATOM 1001 H HA2  . GLY B 2 26  ? 7.78100   19.84580  4.26242  1.000 189.12782 ? 27  GLY B HA2  1 
ATOM 1002 H HA3  . GLY B 2 26  ? 7.52403   19.79251  5.81985  1.000 189.12782 ? 27  GLY B HA3  1 
ATOM 1003 N N    . ILE B 2 27  ? 5.24939   18.11842  4.92239  1.000 194.31799 ? 28  ILE B N    1 
ATOM 1004 C CA   . ILE B 2 27  ? 4.59888   16.88934  4.47970  1.000 181.38056 ? 28  ILE B CA   1 
ATOM 1005 C C    . ILE B 2 27  ? 3.30610   17.24217  3.75665  1.000 159.17371 ? 28  ILE B C    1 
ATOM 1006 O O    . ILE B 2 27  ? 2.69928   18.28694  4.00582  1.000 188.66915 ? 28  ILE B O    1 
ATOM 1007 C CB   . ILE B 2 27  ? 4.31992   15.92167  5.65329  1.000 170.94090 ? 28  ILE B CB   1 
ATOM 1008 C CG1  . ILE B 2 27  ? 3.56935   16.63667  6.77869  1.000 176.93771 ? 28  ILE B CG1  1 
ATOM 1009 C CG2  . ILE B 2 27  ? 5.61977   15.32657  6.17478  1.000 166.58197 ? 28  ILE B CG2  1 
ATOM 1010 C CD1  . ILE B 2 27  ? 2.70504   15.71478  7.60913  1.000 170.29034 ? 28  ILE B CD1  1 
ATOM 1011 H H    . ILE B 2 27  ? 4.70560   18.69386  5.25820  1.000 235.72719 ? 28  ILE B H    1 
ATOM 1012 H HA   . ILE B 2 27  ? 5.18250   16.43874  3.84942  1.000 220.20227 ? 28  ILE B HA   1 
ATOM 1013 H HB   . ILE B 2 27  ? 3.75994   15.20195  5.32264  1.000 207.67468 ? 28  ILE B HB   1 
ATOM 1014 H HG12 . ILE B 2 27  ? 4.21560   17.05162  7.37121  1.000 214.87086 ? 28  ILE B HG12 1 
ATOM 1015 H HG13 . ILE B 2 27  ? 2.99343   17.31341  6.38980  1.000 214.87086 ? 28  ILE B HG13 1 
ATOM 1016 H HG21 . ILE B 2 27  ? 5.41937   14.72344  6.90757  1.000 202.44397 ? 28  ILE B HG21 1 
ATOM 1017 H HG22 . ILE B 2 27  ? 6.05542   14.84133  5.45669  1.000 202.44397 ? 28  ILE B HG22 1 
ATOM 1018 H HG23 . ILE B 2 27  ? 6.19378   16.04443  6.48476  1.000 202.44397 ? 28  ILE B HG23 1 
ATOM 1019 H HD11 . ILE B 2 27  ? 2.05107   15.29015  7.03214  1.000 206.89401 ? 28  ILE B HD11 1 
ATOM 1020 H HD12 . ILE B 2 27  ? 2.25466   16.23494  8.29287  1.000 206.89401 ? 28  ILE B HD12 1 
ATOM 1021 H HD13 . ILE B 2 27  ? 3.26786   15.04164  8.02269  1.000 206.89401 ? 28  ILE B HD13 1 
ATOM 1022 N N    . ARG B 2 28  ? 2.88489   16.35544  2.85553  1.000 177.91410 ? 29  ARG B N    1 
ATOM 1023 C CA   . ARG B 2 28  ? 1.63432   16.51868  2.12203  1.000 205.70768 ? 29  ARG B CA   1 
ATOM 1024 C C    . ARG B 2 28  ? 0.47014   15.91185  2.89802  1.000 204.15947 ? 29  ARG B C    1 
ATOM 1025 O O    . ARG B 2 28  ? 0.51857   14.74264  3.29322  1.000 229.04718 ? 29  ARG B O    1 
ATOM 1026 C CB   . ARG B 2 28  ? 1.73687   15.85771  0.74604  1.000 217.81848 ? 29  ARG B CB   1 
ATOM 1027 C CG   . ARG B 2 28  ? 2.74295   16.49148  -0.20834 1.000 198.54976 ? 29  ARG B CG   1 
ATOM 1028 C CD   . ARG B 2 28  ? 2.30982   17.88278  -0.64275 1.000 207.87221 ? 29  ARG B CD   1 
ATOM 1029 N NE   . ARG B 2 28  ? 1.03174   17.83842  -1.34538 1.000 228.91908 ? 29  ARG B NE   1 
ATOM 1030 C CZ   . ARG B 2 28  ? 0.88732   17.72002  -2.65905 1.000 239.98609 ? 29  ARG B CZ   1 
ATOM 1031 N NH1  . ARG B 2 28  ? 1.93091   17.67195  -3.47226 1.000 235.04451 ? 29  ARG B NH1  1 
ATOM 1032 N NH2  . ARG B 2 28  ? -0.33845  17.64853  -3.17094 1.000 252.95988 ? 29  ARG B NH2  1 
ATOM 1033 H H    . ARG B 2 28  ? 3.31425   15.63947  2.64903  1.000 216.04253 ? 29  ARG B H    1 
ATOM 1034 H HA   . ARG B 2 28  ? 1.45874   17.46597  2.00933  1.000 249.39482 ? 29  ARG B HA   1 
ATOM 1035 H HB2  . ARG B 2 28  ? 1.99909   14.93213  0.87026  1.000 263.92778 ? 29  ARG B HB2  1 
ATOM 1036 H HB3  . ARG B 2 28  ? 0.86649   15.90165  0.32013  1.000 263.92778 ? 29  ARG B HB3  1 
ATOM 1037 H HG2  . ARG B 2 28  ? 3.60233   16.56572  0.23535  1.000 240.80532 ? 29  ARG B HG2  1 
ATOM 1038 H HG3  . ARG B 2 28  ? 2.82535   15.93793  -1.00061 1.000 240.80532 ? 29  ARG B HG3  1 
ATOM 1039 H HD2  . ARG B 2 28  ? 2.21097   18.44879  0.13876  1.000 251.99226 ? 29  ARG B HD2  1 
ATOM 1040 H HD3  . ARG B 2 28  ? 2.97603   18.25624  -1.24074 1.000 251.99226 ? 29  ARG B HD3  1 
ATOM 1041 H HE   . ARG B 2 28  ? 0.31640   17.89329  -0.87115 1.000 277.24850 ? 29  ARG B HE   1 
ATOM 1042 H HH11 . ARG B 2 28  ? 2.72785   17.71776  -3.15229 1.000 284.59902 ? 29  ARG B HH11 1 
ATOM 1043 H HH12 . ARG B 2 28  ? 1.81188   17.59493  -4.32049 1.000 284.59902 ? 29  ARG B HH12 1 
ATOM 1044 H HH21 . ARG B 2 28  ? -1.02359  17.67921  -2.65205 1.000 306.09746 ? 29  ARG B HH21 1 
ATOM 1045 H HH22 . ARG B 2 28  ? -0.44574  17.57164  -4.02075 1.000 306.09746 ? 29  ARG B HH22 1 
ATOM 1046 N N    . VAL B 2 29  ? -0.57546  16.71682  3.11435  1.000 190.95094 ? 30  VAL B N    1 
ATOM 1047 C CA   . VAL B 2 29  ? -1.77167  16.24178  3.80342  1.000 185.57134 ? 30  VAL B CA   1 
ATOM 1048 C C    . VAL B 2 29  ? -2.57027  15.23768  2.98166  1.000 176.77901 ? 30  VAL B C    1 
ATOM 1049 O O    . VAL B 2 29  ? -3.34265  14.46017  3.55408  1.000 171.04120 ? 30  VAL B O    1 
ATOM 1050 C CB   . VAL B 2 29  ? -2.67325  17.42548  4.20641  1.000 182.24459 ? 30  VAL B CB   1 
ATOM 1051 C CG1  . VAL B 2 29  ? -1.89982  18.42133  5.05495  1.000 192.78237 ? 30  VAL B CG1  1 
ATOM 1052 C CG2  . VAL B 2 29  ? -3.25402  18.11118  2.97306  1.000 208.19202 ? 30  VAL B CG2  1 
ATOM 1053 H H    . VAL B 2 29  ? -0.61470  17.54085  2.87136  1.000 231.68673 ? 30  VAL B H    1 
ATOM 1054 H HA   . VAL B 2 29  ? -1.47121  15.78825  4.60650  1.000 225.23121 ? 30  VAL B HA   1 
ATOM 1055 H HB   . VAL B 2 29  ? -3.41166  17.08417  4.73477  1.000 221.23911 ? 30  VAL B HB   1 
ATOM 1056 H HG11 . VAL B 2 29  ? -2.50210  19.12447  5.34436  1.000 233.88445 ? 30  VAL B HG11 1 
ATOM 1057 H HG12 . VAL B 2 29  ? -1.18187  18.79890  4.52308  1.000 233.88445 ? 30  VAL B HG12 1 
ATOM 1058 H HG13 . VAL B 2 29  ? -1.53337  17.96140  5.82636  1.000 233.88445 ? 30  VAL B HG13 1 
ATOM 1059 H HG21 . VAL B 2 29  ? -3.78694  18.87083  3.25561  1.000 252.37603 ? 30  VAL B HG21 1 
ATOM 1060 H HG22 . VAL B 2 29  ? -3.80951  17.47807  2.49192  1.000 252.37603 ? 30  VAL B HG22 1 
ATOM 1061 H HG23 . VAL B 2 29  ? -2.52617  18.41036  2.40593  1.000 252.37603 ? 30  VAL B HG23 1 
ATOM 1062 N N    . ASN B 2 30  ? -2.40680  15.21231  1.66100  1.000 210.75009 ? 31  ASN B N    1 
ATOM 1063 C CA   . ASN B 2 30  ? -3.05887  14.19163  0.85186  1.000 197.50102 ? 31  ASN B CA   1 
ATOM 1064 C C    . ASN B 2 30  ? -2.23984  12.90984  0.77604  1.000 181.69393 ? 31  ASN B C    1 
ATOM 1065 O O    . ASN B 2 30  ? -2.64690  11.96825  0.08787  1.000 174.27804 ? 31  ASN B O    1 
ATOM 1066 C CB   . ASN B 2 30  ? -3.36406  14.73655  -0.55051 1.000 204.33367 ? 31  ASN B CB   1 
ATOM 1067 C CG   . ASN B 2 30  ? -2.13451  14.86219  -1.41868 1.000 221.04731 ? 31  ASN B CG   1 
ATOM 1068 O OD1  . ASN B 2 30  ? -1.01543  14.99117  -0.92469 1.000 231.67119 ? 31  ASN B OD1  1 
ATOM 1069 N ND2  . ASN B 2 30  ? -2.34380  14.86108  -2.72997 1.000 216.94197 ? 31  ASN B ND2  1 
ATOM 1070 H H    . ASN B 2 30  ? -1.92721  15.77114  1.21681  1.000 255.44571 ? 31  ASN B H    1 
ATOM 1071 H HA   . ASN B 2 30  ? -3.91501  13.96413  1.24704  1.000 239.54683 ? 31  ASN B HA   1 
ATOM 1072 H HB2  . ASN B 2 30  ? -3.98236  14.13506  -0.99414 1.000 247.74601 ? 31  ASN B HB2  1 
ATOM 1073 H HB3  . ASN B 2 30  ? -3.76110  15.61755  -0.46624 1.000 247.74601 ? 31  ASN B HB3  1 
ATOM 1074 H HD21 . ASN B 2 30  ? -3.14385  14.79146  -3.03767 1.000 262.87597 ? 31  ASN B HD21 1 
ATOM 1075 H HD22 . ASN B 2 30  ? -1.67930  14.92999  -3.27153 1.000 262.87597 ? 31  ASN B HD22 1 
ATOM 1076 N N    . VAL B 2 31  ? -1.09868  12.86278  1.46487  1.000 187.91493 ? 32  VAL B N    1 
ATOM 1077 C CA   . VAL B 2 31  ? -0.29741  11.65552  1.56634  1.000 166.55020 ? 32  VAL B CA   1 
ATOM 1078 C C    . VAL B 2 31  ? -0.35104  11.06093  2.96852  1.000 164.71354 ? 32  VAL B C    1 
ATOM 1079 O O    . VAL B 2 31  ? -0.19680  9.84356   3.11853  1.000 181.55144 ? 32  VAL B O    1 
ATOM 1080 C CB   . VAL B 2 31  ? 1.16545   11.93485  1.15895  1.000 152.18486 ? 32  VAL B CB   1 
ATOM 1081 C CG1  . VAL B 2 31  ? 2.03520   10.70034  1.37596  1.000 153.20487 ? 32  VAL B CG1  1 
ATOM 1082 C CG2  . VAL B 2 31  ? 1.23742   12.37814  -0.26898 1.000 171.35941 ? 32  VAL B CG2  1 
ATOM 1083 H H    . VAL B 2 31  ? -0.76525  13.53272  1.88867  1.000 228.04352 ? 32  VAL B H    1 
ATOM 1084 H HA   . VAL B 2 31  ? -0.65248  10.98690  0.95989  1.000 202.40584 ? 32  VAL B HA   1 
ATOM 1085 H HB   . VAL B 2 31  ? 1.50986   12.64797  1.71908  1.000 185.16743 ? 32  VAL B HB   1 
ATOM 1086 H HG11 . VAL B 2 31  ? 2.91254   10.86118  0.99479  1.000 186.39145 ? 32  VAL B HG11 1 
ATOM 1087 H HG12 . VAL B 2 31  ? 1.61928   9.94035   0.93969  1.000 186.39145 ? 32  VAL B HG12 1 
ATOM 1088 H HG13 . VAL B 2 31  ? 2.11387   10.53287  2.32815  1.000 186.39145 ? 32  VAL B HG13 1 
ATOM 1089 H HG21 . VAL B 2 31  ? 2.16463   12.54103  -0.50273 1.000 208.17689 ? 32  VAL B HG21 1 
ATOM 1090 H HG22 . VAL B 2 31  ? 0.72197   13.19325  -0.37296 1.000 208.17689 ? 32  VAL B HG22 1 
ATOM 1091 H HG23 . VAL B 2 31  ? 0.87120   11.68072  -0.83500 1.000 208.17689 ? 32  VAL B HG23 1 
ATOM 1092 N N    . ASN B 2 32  ? -0.51112  11.89101  3.99430  1.000 174.37223 ? 33  ASN B N    1 
ATOM 1093 C CA   . ASN B 2 32  ? -0.40738  11.49615  5.39021  1.000 148.85748 ? 33  ASN B CA   1 
ATOM 1094 C C    . ASN B 2 32  ? -1.76970  11.61674  6.06321  1.000 163.31630 ? 33  ASN B C    1 
ATOM 1095 O O    . ASN B 2 32  ? -2.49818  12.59001  5.84108  1.000 176.99244 ? 33  ASN B O    1 
ATOM 1096 C CB   . ASN B 2 32  ? 0.64108   12.34308  6.11723  1.000 140.89348 ? 33  ASN B CB   1 
ATOM 1097 C CG   . ASN B 2 32  ? 2.05355   12.05095  5.63842  1.000 142.60545 ? 33  ASN B CG   1 
ATOM 1098 O OD1  . ASN B 2 32  ? 2.72020   11.14930  6.14870  1.000 142.83591 ? 33  ASN B OD1  1 
ATOM 1099 N ND2  . ASN B 2 32  ? 2.50744   12.79745  4.63803  1.000 173.86043 ? 33  ASN B ND2  1 
ATOM 1100 H H    . ASN B 2 32  ? -0.68887  12.72711  3.89979  1.000 211.79228 ? 33  ASN B H    1 
ATOM 1101 H HA   . ASN B 2 32  ? -0.13185  10.56836  5.45496  1.000 181.17459 ? 33  ASN B HA   1 
ATOM 1102 H HB2  . ASN B 2 32  ? 0.45682   13.28204  5.95815  1.000 171.61778 ? 33  ASN B HB2  1 
ATOM 1103 H HB3  . ASN B 2 32  ? 0.59942   12.15319  7.06755  1.000 171.61778 ? 33  ASN B HB3  1 
ATOM 1104 H HD21 . ASN B 2 32  ? 2.00778   13.40827  4.29623  1.000 211.17812 ? 33  ASN B HD21 1 
ATOM 1105 H HD22 . ASN B 2 32  ? 3.30101   12.66999  4.33208  1.000 211.17812 ? 33  ASN B HD22 1 
ATOM 1106 N N    . ALA B 2 33  ? -2.11695  10.61867  6.87299  1.000 180.98087 ? 34  ALA B N    1 
ATOM 1107 C CA   . ALA B 2 33  ? -3.16542  10.80421  7.86809  1.000 176.17602 ? 34  ALA B CA   1 
ATOM 1108 C C    . ALA B 2 33  ? -2.81489  11.96191  8.79602  1.000 157.65063 ? 34  ALA B C    1 
ATOM 1109 O O    . ALA B 2 33  ? -1.66093  12.13272  9.19722  1.000 159.73732 ? 34  ALA B O    1 
ATOM 1110 C CB   . ALA B 2 33  ? -3.36150  9.52098   8.67323  1.000 170.28896 ? 34  ALA B CB   1 
ATOM 1111 H H    . ALA B 2 33  ? -1.76455  9.83422   6.86579  1.000 219.72265 ? 34  ALA B H    1 
ATOM 1112 H HA   . ALA B 2 33  ? -4.00238  11.01116  7.42360  1.000 213.95683 ? 34  ALA B HA   1 
ATOM 1113 H HB1  . ALA B 2 33  ? -3.54995  8.79094   8.06296  1.000 206.89236 ? 34  ALA B HB1  1 
ATOM 1114 H HB2  . ALA B 2 33  ? -2.55086  9.33419   9.17210  1.000 206.89236 ? 34  ALA B HB2  1 
ATOM 1115 H HB3  . ALA B 2 33  ? -4.10530  9.64192   9.28400  1.000 206.89236 ? 34  ALA B HB3  1 
ATOM 1116 N N    . MET B 2 34  ? -3.82373  12.76146  9.13476  1.000 129.28404 ? 35  MET B N    1 
ATOM 1117 C CA   . MET B 2 34  ? -3.65527  13.93732  9.97422  1.000 122.91797 ? 35  MET B CA   1 
ATOM 1118 C C    . MET B 2 34  ? -4.65520  13.91269  11.12343 1.000 130.39759 ? 35  MET B C    1 
ATOM 1119 O O    . MET B 2 34  ? -5.80709  13.49336  10.95315 1.000 146.22987 ? 35  MET B O    1 
ATOM 1120 C CB   . MET B 2 34  ? -3.82775  15.22049  9.14922  1.000 162.29169 ? 35  MET B CB   1 
ATOM 1121 C CG   . MET B 2 34  ? -2.72218  15.44217  8.11855  1.000 177.13984 ? 35  MET B CG   1 
ATOM 1122 S SD   . MET B 2 34  ? -1.06268  15.58279  8.81679  1.000 170.69264 ? 35  MET B SD   1 
ATOM 1123 C CE   . MET B 2 34  ? -1.17127  17.14715  9.67864  1.000 164.03436 ? 35  MET B CE   1 
ATOM 1124 H H    . MET B 2 34  ? -4.63628  12.63725  8.88190  1.000 157.68645 ? 35  MET B H    1 
ATOM 1125 H HA   . MET B 2 34  ? -2.76260  13.93410  10.35374 1.000 150.04717 ? 35  MET B HA   1 
ATOM 1126 H HB2  . MET B 2 34  ? -4.67160  15.17410  8.67313  1.000 197.29563 ? 35  MET B HB2  1 
ATOM 1127 H HB3  . MET B 2 34  ? -3.82801  15.98083  9.75154  1.000 197.29563 ? 35  MET B HB3  1 
ATOM 1128 H HG2  . MET B 2 34  ? -2.71795  14.69207  7.50354  1.000 215.11341 ? 35  MET B HG2  1 
ATOM 1129 H HG3  . MET B 2 34  ? -2.90775  16.26411  7.63806  1.000 215.11341 ? 35  MET B HG3  1 
ATOM 1130 H HE1  . MET B 2 34  ? -0.28534  17.40501  9.97787  1.000 199.38683 ? 35  MET B HE1  1 
ATOM 1131 H HE2  . MET B 2 34  ? -1.52398  17.81762  9.07287  1.000 199.38683 ? 35  MET B HE2  1 
ATOM 1132 H HE3  . MET B 2 34  ? -1.76198  17.04709  10.44150 1.000 199.38683 ? 35  MET B HE3  1 
ATOM 1133 N N    . TYR B 2 35  ? -4.20543  14.35914  12.29799 1.000 138.37050 ? 36  TYR B N    1 
ATOM 1134 C CA   . TYR B 2 35  ? -4.95771  14.27315  13.54004 1.000 121.98095 ? 36  TYR B CA   1 
ATOM 1135 C C    . TYR B 2 35  ? -5.16491  15.67333  14.09629 1.000 127.95650 ? 36  TYR B C    1 
ATOM 1136 O O    . TYR B 2 35  ? -4.28648  16.53503  13.97628 1.000 161.48349 ? 36  TYR B O    1 
ATOM 1137 C CB   . TYR B 2 35  ? -4.22206  13.45929  14.61878 1.000 122.33180 ? 36  TYR B CB   1 
ATOM 1138 C CG   . TYR B 2 35  ? -3.95313  11.99920  14.33229 1.000 138.76777 ? 36  TYR B CG   1 
ATOM 1139 C CD1  . TYR B 2 35  ? -4.36794  11.39551  13.15426 1.000 163.29307 ? 36  TYR B CD1  1 
ATOM 1140 C CD2  . TYR B 2 35  ? -3.25002  11.22901  15.24949 1.000 153.94866 ? 36  TYR B CD2  1 
ATOM 1141 C CE1  . TYR B 2 35  ? -4.10322  10.05932  12.90820 1.000 196.36015 ? 36  TYR B CE1  1 
ATOM 1142 C CE2  . TYR B 2 35  ? -2.99008  9.89978   15.01661 1.000 177.10265 ? 36  TYR B CE2  1 
ATOM 1143 C CZ   . TYR B 2 35  ? -3.41817  9.31621   13.84690 1.000 190.53058 ? 36  TYR B CZ   1 
ATOM 1144 O OH   . TYR B 2 35  ? -3.14342  7.98887   13.61456 1.000 209.36227 ? 36  TYR B OH   1 
ATOM 1145 H H    . TYR B 2 35  ? -3.43600  14.72972  12.39918 1.000 168.59020 ? 36  TYR B H    1 
ATOM 1146 H HA   . TYR B 2 35  ? -5.80760  13.84695  13.34785 1.000 148.92274 ? 36  TYR B HA   1 
ATOM 1147 H HB2  . TYR B 2 35  ? -3.36022  13.87782  14.77030 1.000 149.34376 ? 36  TYR B HB2  1 
ATOM 1148 H HB3  . TYR B 2 35  ? -4.75377  13.49182  15.42941 1.000 149.34376 ? 36  TYR B HB3  1 
ATOM 1149 H HD1  . TYR B 2 35  ? -4.83036  11.89550  12.52095 1.000 198.49728 ? 36  TYR B HD1  1 
ATOM 1150 H HD2  . TYR B 2 35  ? -2.94895  11.62078  16.03738 1.000 187.28400 ? 36  TYR B HD2  1 
ATOM 1151 H HE1  . TYR B 2 35  ? -4.38556  9.66494   12.11470 1.000 238.17778 ? 36  TYR B HE1  1 
ATOM 1152 H HE2  . TYR B 2 35  ? -2.52678  9.39705   15.64709 1.000 215.06878 ? 36  TYR B HE2  1 
ATOM 1153 H HH   . TYR B 2 35  ? -2.67884  7.67765   14.24138 1.000 253.78033 ? 36  TYR B HH   1 
ATOM 1154 N N    . TRP B 2 36  ? -6.32625  15.88845  14.70798 1.000 106.98462 ? 37  TRP B N    1 
ATOM 1155 C CA   . TRP B 2 36  ? -6.54544  16.98214  15.64020 1.000 147.02744 ? 37  TRP B CA   1 
ATOM 1156 C C    . TRP B 2 36  ? -6.63410  16.42731  17.05539 1.000 137.34985 ? 37  TRP B C    1 
ATOM 1157 O O    . TRP B 2 36  ? -7.35817  15.45335  17.30534 1.000 146.93399 ? 37  TRP B O    1 
ATOM 1158 C CB   . TRP B 2 36  ? -7.83362  17.73688  15.30027 1.000 145.13892 ? 37  TRP B CB   1 
ATOM 1159 C CG   . TRP B 2 36  ? -7.70317  18.73904  14.19088 1.000 146.90018 ? 37  TRP B CG   1 
ATOM 1160 C CD1  . TRP B 2 36  ? -8.00721  18.55041  12.87272 1.000 144.39558 ? 37  TRP B CD1  1 
ATOM 1161 C CD2  . TRP B 2 36  ? -7.24069  20.09110  14.30511 1.000 136.41109 ? 37  TRP B CD2  1 
ATOM 1162 N NE1  . TRP B 2 36  ? -7.77622  19.70420  12.16360 1.000 138.91702 ? 37  TRP B NE1  1 
ATOM 1163 C CE2  . TRP B 2 36  ? -7.29083  20.66008  13.01624 1.000 146.80907 ? 37  TRP B CE2  1 
ATOM 1164 C CE3  . TRP B 2 36  ? -6.79332  20.87647  15.37163 1.000 142.86215 ? 37  TRP B CE3  1 
ATOM 1165 C CZ2  . TRP B 2 36  ? -6.90611  21.97492  12.76454 1.000 157.11160 ? 37  TRP B CZ2  1 
ATOM 1166 C CZ3  . TRP B 2 36  ? -6.41429  22.18324  15.11959 1.000 140.49845 ? 37  TRP B CZ3  1 
ATOM 1167 C CH2  . TRP B 2 36  ? -6.48567  22.72268  13.82810 1.000 165.85276 ? 37  TRP B CH2  1 
ATOM 1168 H H    . TRP B 2 36  ? -7.02233  15.39663  14.59317 1.000 130.92715 ? 37  TRP B H    1 
ATOM 1169 H HA   . TRP B 2 36  ? -5.80499  17.60720  15.59625 1.000 178.97854 ? 37  TRP B HA   1 
ATOM 1170 H HB2  . TRP B 2 36  ? -8.50670  17.09178  15.03248 1.000 176.71231 ? 37  TRP B HB2  1 
ATOM 1171 H HB3  . TRP B 2 36  ? -8.12820  18.21470  16.09136 1.000 176.71231 ? 37  TRP B HB3  1 
ATOM 1172 H HD1  . TRP B 2 36  ? -8.32463  17.75596  12.50802 1.000 175.82030 ? 37  TRP B HD1  1 
ATOM 1173 H HE1  . TRP B 2 36  ? -7.91399  19.80925  11.32124 1.000 169.24602 ? 37  TRP B HE1  1 
ATOM 1174 H HE3  . TRP B 2 36  ? -6.75131  20.52784  16.23279 1.000 173.98019 ? 37  TRP B HE3  1 
ATOM 1175 H HZ2  . TRP B 2 36  ? -6.93433  22.33024  11.90556 1.000 191.07952 ? 37  TRP B HZ2  1 
ATOM 1176 H HZ3  . TRP B 2 36  ? -6.10680  22.71281  15.81952 1.000 171.14374 ? 37  TRP B HZ3  1 
ATOM 1177 H HH2  . TRP B 2 36  ? -6.24136  23.60961  13.69186 1.000 201.56891 ? 37  TRP B HH2  1 
ATOM 1178 N N    . TYR B 2 37  ? -5.96583  17.12800  17.97421 1.000 120.07262 ? 38  TYR B N    1 
ATOM 1179 C CA   . TYR B 2 37  ? -5.89763  16.86436  19.40077 1.000 124.86154 ? 38  TYR B CA   1 
ATOM 1180 C C    . TYR B 2 37  ? -6.38842  18.10510  20.13287 1.000 118.68261 ? 38  TYR B C    1 
ATOM 1181 O O    . TYR B 2 37  ? -6.42177  19.20112  19.56839 1.000 143.29187 ? 38  TYR B O    1 
ATOM 1182 C CB   . TYR B 2 37  ? -4.44760  16.61327  19.84621 1.000 169.91170 ? 38  TYR B CB   1 
ATOM 1183 C CG   . TYR B 2 37  ? -3.80570  15.33895  19.35608 1.000 141.80601 ? 38  TYR B CG   1 
ATOM 1184 C CD1  . TYR B 2 37  ? -3.18557  15.30496  18.11482 1.000 142.58440 ? 38  TYR B CD1  1 
ATOM 1185 C CD2  . TYR B 2 37  ? -3.69599  14.22184  20.17224 1.000 132.77753 ? 38  TYR B CD2  1 
ATOM 1186 C CE1  . TYR B 2 37  ? -2.57256  14.16703  17.65298 1.000 174.96215 ? 38  TYR B CE1  1 
ATOM 1187 C CE2  . TYR B 2 37  ? -3.06962  13.07436  19.72050 1.000 149.62407 ? 38  TYR B CE2  1 
ATOM 1188 C CZ   . TYR B 2 37  ? -2.51880  13.05233  18.45235 1.000 173.09730 ? 38  TYR B CZ   1 
ATOM 1189 O OH   . TYR B 2 37  ? -1.86208  11.93781  17.99396 1.000 144.40883 ? 38  TYR B OH   1 
ATOM 1190 H H    . TYR B 2 37  ? -5.50348  17.82391  17.77040 1.000 146.63275 ? 38  TYR B H    1 
ATOM 1191 H HA   . TYR B 2 37  ? -6.44131  16.09144  19.61961 1.000 152.37946 ? 38  TYR B HA   1 
ATOM 1192 H HB2  . TYR B 2 37  ? -3.90211  17.34839  19.52537 1.000 206.43965 ? 38  TYR B HB2  1 
ATOM 1193 H HB3  . TYR B 2 37  ? -4.43051  16.58594  20.81567 1.000 206.43965 ? 38  TYR B HB3  1 
ATOM 1194 H HD1  . TYR B 2 37  ? -3.18540  16.06923  17.58492 1.000 173.64689 ? 38  TYR B HD1  1 
ATOM 1195 H HD2  . TYR B 2 37  ? -4.04770  14.24506  21.03286 1.000 161.87863 ? 38  TYR B HD2  1 
ATOM 1196 H HE1  . TYR B 2 37  ? -2.19561  14.15128  16.80294 1.000 212.50018 ? 38  TYR B HE1  1 
ATOM 1197 H HE2  . TYR B 2 37  ? -3.01926  12.32278  20.26593 1.000 182.09449 ? 38  TYR B HE2  1 
ATOM 1198 H HH   . TYR B 2 37  ? -1.94436  11.30899  18.54480 1.000 175.83620 ? 38  TYR B HH   1 
ATOM 1199 N N    . ARG B 2 38  ? -6.74013  17.94528  21.40496 1.000 126.44410 ? 39  ARG B N    1 
ATOM 1200 C CA   . ARG B 2 38  ? -6.95464  19.09048  22.27715 1.000 159.65994 ? 39  ARG B CA   1 
ATOM 1201 C C    . ARG B 2 38  ? -6.35094  18.79273  23.64287 1.000 121.52285 ? 39  ARG B C    1 
ATOM 1202 O O    . ARG B 2 38  ? -6.15545  17.63706  24.01781 1.000 102.30388 ? 39  ARG B O    1 
ATOM 1203 C CB   . ARG B 2 38  ? -8.43942  19.45548  22.37258 1.000 226.71380 ? 39  ARG B CB   1 
ATOM 1204 C CG   . ARG B 2 38  ? -9.28429  18.50213  23.16969 1.000 204.55576 ? 39  ARG B CG   1 
ATOM 1205 C CD   . ARG B 2 38  ? -10.72533 18.91848  23.08059 1.000 166.97172 ? 39  ARG B CD   1 
ATOM 1206 N NE   . ARG B 2 38  ? -11.60134 18.04652  23.84769 1.000 196.75546 ? 39  ARG B NE   1 
ATOM 1207 C CZ   . ARG B 2 38  ? -12.91931 18.16782  23.87459 1.000 203.97479 ? 39  ARG B CZ   1 
ATOM 1208 N NH1  . ARG B 2 38  ? -13.54165 19.06537  23.13157 1.000 222.78759 ? 39  ARG B NH1  1 
ATOM 1209 N NH2  . ARG B 2 38  ? -13.63111 17.36091  24.65551 1.000 216.82473 ? 39  ARG B NH2  1 
ATOM 1210 H H    . ARG B 2 38  ? -6.86020  17.18292  21.78442 1.000 154.27853 ? 39  ARG B H    1 
ATOM 1211 H HA   . ARG B 2 38  ? -6.49438  19.86924  21.92700 1.000 194.13753 ? 39  ARG B HA   1 
ATOM 1212 H HB2  . ARG B 2 38  ? -8.51381  20.32758  22.79067 1.000 274.60217 ? 39  ARG B HB2  1 
ATOM 1213 H HB3  . ARG B 2 38  ? -8.80535  19.48568  21.47476 1.000 274.60217 ? 39  ARG B HB3  1 
ATOM 1214 H HG2  . ARG B 2 38  ? -9.19437  17.60477  22.81255 1.000 248.01252 ? 39  ARG B HG2  1 
ATOM 1215 H HG3  . ARG B 2 38  ? -9.01014  18.51796  24.10001 1.000 248.01252 ? 39  ARG B HG3  1 
ATOM 1216 H HD2  . ARG B 2 38  ? -10.81788 19.81961  23.42744 1.000 202.91167 ? 39  ARG B HD2  1 
ATOM 1217 H HD3  . ARG B 2 38  ? -11.00785 18.88935  22.15310 1.000 202.91167 ? 39  ARG B HD3  1 
ATOM 1218 H HE   . ARG B 2 38  ? -11.24259 17.41635  24.31006 1.000 238.65215 ? 39  ARG B HE   1 
ATOM 1219 H HH11 . ARG B 2 38  ? -13.08976 19.58562  22.61705 1.000 269.89071 ? 39  ARG B HH11 1 
ATOM 1220 H HH12 . ARG B 2 38  ? -14.39871 19.12945  23.16236 1.000 269.89071 ? 39  ARG B HH12 1 
ATOM 1221 H HH21 . ARG B 2 38  ? -13.23481 16.76805  25.13621 1.000 262.73528 ? 39  ARG B HH21 1 
ATOM 1222 H HH22 . ARG B 2 38  ? -14.48783 17.43182  24.67997 1.000 262.73528 ? 39  ARG B HH22 1 
ATOM 1223 N N    . GLN B 2 39  ? -6.03325  19.85570  24.37617 1.000 153.88040 ? 40  GLN B N    1 
ATOM 1224 C CA   . GLN B 2 39  ? -5.50937  19.74176  25.73557 1.000 147.64168 ? 40  GLN B CA   1 
ATOM 1225 C C    . GLN B 2 39  ? -6.11531  20.85913  26.57347 1.000 180.09706 ? 40  GLN B C    1 
ATOM 1226 O O    . GLN B 2 39  ? -5.89938  22.04260  26.28589 1.000 163.84844 ? 40  GLN B O    1 
ATOM 1227 C CB   . GLN B 2 39  ? -3.98052  19.80151  25.75535 1.000 189.58171 ? 40  GLN B CB   1 
ATOM 1228 C CG   . GLN B 2 39  ? -3.36809  19.42970  27.09886 1.000 220.69904 ? 40  GLN B CG   1 
ATOM 1229 C CD   . GLN B 2 39  ? -1.85568  19.34287  27.04785 1.000 203.48357 ? 40  GLN B CD   1 
ATOM 1230 O OE1  . GLN B 2 39  ? -1.21420  19.96794  26.20320 1.000 189.21340 ? 40  GLN B OE1  1 
ATOM 1231 N NE2  . GLN B 2 39  ? -1.27678  18.56246  27.95457 1.000 176.20449 ? 40  GLN B NE2  1 
ATOM 1232 H H    . GLN B 2 39  ? -6.11334  20.66771  24.10445 1.000 187.20208 ? 40  GLN B H    1 
ATOM 1233 H HA   . GLN B 2 39  ? -5.78320  18.89218  26.11522 1.000 179.71562 ? 40  GLN B HA   1 
ATOM 1234 H HB2  . GLN B 2 39  ? -3.63595  19.18345  25.09189 1.000 230.04366 ? 40  GLN B HB2  1 
ATOM 1235 H HB3  . GLN B 2 39  ? -3.70128  20.70584  25.54297 1.000 230.04366 ? 40  GLN B HB3  1 
ATOM 1236 H HG2  . GLN B 2 39  ? -3.60821  20.10402  27.75349 1.000 267.38445 ? 40  GLN B HG2  1 
ATOM 1237 H HG3  . GLN B 2 39  ? -3.70942  18.56428  27.37352 1.000 267.38445 ? 40  GLN B HG3  1 
ATOM 1238 H HE21 . GLN B 2 39  ? -1.75811  18.14011  28.52863 1.000 213.99099 ? 40  GLN B HE21 1 
ATOM 1239 H HE22 . GLN B 2 39  ? -0.42086  18.47981  27.96724 1.000 213.99099 ? 40  GLN B HE22 1 
ATOM 1240 N N    . ALA B 2 40  ? -6.95612  20.48043  27.53489 1.000 204.21649 ? 41  ALA B N    1 
ATOM 1241 C CA   . ALA B 2 40  ? -7.44486  21.39184  28.55556 1.000 217.41891 ? 41  ALA B CA   1 
ATOM 1242 C C    . ALA B 2 40  ? -6.39110  21.60501  29.64167 1.000 211.82747 ? 41  ALA B C    1 
ATOM 1243 O O    . ALA B 2 40  ? -5.48769  20.78322  29.81489 1.000 179.16491 ? 41  ALA B O    1 
ATOM 1244 C CB   . ALA B 2 40  ? -8.73159  20.84962  29.16951 1.000 243.98961 ? 41  ALA B CB   1 
ATOM 1245 H H    . ALA B 2 40  ? -7.26324  19.68128  27.61635 1.000 247.60540 ? 41  ALA B H    1 
ATOM 1246 H HA   . ALA B 2 40  ? -7.64131  22.25273  28.15411 1.000 263.44830 ? 41  ALA B HA   1 
ATOM 1247 H HB1  . ALA B 2 40  ? -9.38908  20.72621  28.46711 1.000 295.33314 ? 41  ALA B HB1  1 
ATOM 1248 H HB2  . ALA B 2 40  ? -8.54319  20.00060  29.59913 1.000 295.33314 ? 41  ALA B HB2  1 
ATOM 1249 H HB3  . ALA B 2 40  ? -9.06170  21.48528  29.82363 1.000 295.33314 ? 41  ALA B HB3  1 
ATOM 1250 N N    . PRO B 2 41  ? -6.47302  22.71535  30.37504 1.000 199.37598 ? 42  PRO B N    1 
ATOM 1251 C CA   . PRO B 2 41  ? -5.45042  23.00916  31.39096 1.000 209.69205 ? 42  PRO B CA   1 
ATOM 1252 C C    . PRO B 2 41  ? -5.31837  21.89380  32.42060 1.000 189.48081 ? 42  PRO B C    1 
ATOM 1253 O O    . PRO B 2 41  ? -6.30608  21.43754  33.00073 1.000 183.71372 ? 42  PRO B O    1 
ATOM 1254 C CB   . PRO B 2 41  ? -5.94966  24.31035  32.03328 1.000 218.66535 ? 42  PRO B CB   1 
ATOM 1255 C CG   . PRO B 2 41  ? -6.89068  24.90694  31.04069 1.000 245.62214 ? 42  PRO B CG   1 
ATOM 1256 C CD   . PRO B 2 41  ? -7.51448  23.75552  30.32323 1.000 242.83286 ? 42  PRO B CD   1 
ATOM 1257 H HA   . PRO B 2 41  ? -4.59183  23.15195  30.96279 1.000 254.17607 ? 42  PRO B HA   1 
ATOM 1258 H HB2  . PRO B 2 41  ? -6.40583  24.11166  32.86594 1.000 264.94402 ? 42  PRO B HB2  1 
ATOM 1259 H HB3  . PRO B 2 41  ? -5.20023  24.90350  32.19891 1.000 264.94402 ? 42  PRO B HB3  1 
ATOM 1260 H HG2  . PRO B 2 41  ? -7.56487  25.42941  31.50264 1.000 297.29217 ? 42  PRO B HG2  1 
ATOM 1261 H HG3  . PRO B 2 41  ? -6.39962  25.47092  30.42288 1.000 297.29217 ? 42  PRO B HG3  1 
ATOM 1262 H HD2  . PRO B 2 41  ? -8.31891  23.46084  30.77815 1.000 293.94503 ? 42  PRO B HD2  1 
ATOM 1263 H HD3  . PRO B 2 41  ? -7.72017  23.99193  29.40524 1.000 293.94503 ? 42  PRO B HD3  1 
ATOM 1264 N N    . GLY B 2 42  ? -4.07812  21.46067  32.64488 1.000 219.32648 ? 43  GLY B N    1 
ATOM 1265 C CA   . GLY B 2 42  ? -3.76580  20.42093  33.60498 1.000 262.37048 ? 43  GLY B CA   1 
ATOM 1266 C C    . GLY B 2 42  ? -4.23226  19.02616  33.25381 1.000 181.95694 ? 43  GLY B C    1 
ATOM 1267 O O    . GLY B 2 42  ? -4.04357  18.11303  34.06597 1.000 193.16789 ? 43  GLY B O    1 
ATOM 1268 H H    . GLY B 2 42  ? -3.38438  21.76606  32.23860 1.000 265.73738 ? 43  GLY B H    1 
ATOM 1269 H HA2  . GLY B 2 42  ? -2.80262  20.38578  33.71427 1.000 317.39018 ? 43  GLY B HA2  1 
ATOM 1270 H HA3  . GLY B 2 42  ? -4.17151  20.65740  34.45373 1.000 317.39018 ? 43  GLY B HA3  1 
ATOM 1271 N N    . LYS B 2 43  ? -4.82936  18.82100  32.08475 1.000 195.35011 ? 44  LYS B N    1 
ATOM 1272 C CA   . LYS B 2 43  ? -5.27073  17.50361  31.65389 1.000 203.31075 ? 44  LYS B CA   1 
ATOM 1273 C C    . LYS B 2 43  ? -4.38410  16.96297  30.53723 1.000 209.94198 ? 44  LYS B C    1 
ATOM 1274 O O    . LYS B 2 43  ? -3.65005  17.69614  29.86893 1.000 194.58447 ? 44  LYS B O    1 
ATOM 1275 C CB   . LYS B 2 43  ? -6.74791  17.50524  31.24452 1.000 214.07390 ? 44  LYS B CB   1 
ATOM 1276 C CG   . LYS B 2 43  ? -7.65903  17.84323  32.42672 1.000 270.13508 ? 44  LYS B CG   1 
ATOM 1277 C CD   . LYS B 2 43  ? -9.11286  18.18057  32.07929 1.000 268.54254 ? 44  LYS B CD   1 
ATOM 1278 C CE   . LYS B 2 43  ? -9.68937  17.35666  30.92442 1.000 222.32596 ? 44  LYS B CE   1 
ATOM 1279 N NZ   . LYS B 2 43  ? -10.38867 16.13990  31.43139 1.000 228.09257 ? 44  LYS B NZ   1 
ATOM 1280 H H    . LYS B 2 43  ? -4.99213  19.44336  31.51397 1.000 236.96574 ? 44  LYS B H    1 
ATOM 1281 H HA   . LYS B 2 43  ? -5.18565  16.88903  32.39951 1.000 246.51850 ? 44  LYS B HA   1 
ATOM 1282 H HB2  . LYS B 2 43  ? -6.88745  18.16964  30.55170 1.000 259.43429 ? 44  LYS B HB2  1 
ATOM 1283 H HB3  . LYS B 2 43  ? -6.98965  16.62579  30.91433 1.000 259.43429 ? 44  LYS B HB3  1 
ATOM 1284 H HG2  . LYS B 2 43  ? -7.67804  17.07917  33.02401 1.000 326.70770 ? 44  LYS B HG2  1 
ATOM 1285 H HG3  . LYS B 2 43  ? -7.28882  18.61367  32.88527 1.000 326.70770 ? 44  LYS B HG3  1 
ATOM 1286 H HD2  . LYS B 2 43  ? -9.66499  18.01786  32.86005 1.000 324.79665 ? 44  LYS B HD2  1 
ATOM 1287 H HD3  . LYS B 2 43  ? -9.16324  19.11566  31.82637 1.000 324.79665 ? 44  LYS B HD3  1 
ATOM 1288 H HE2  . LYS B 2 43  ? -10.32819 17.89480  30.43125 1.000 269.33676 ? 44  LYS B HE2  1 
ATOM 1289 H HE3  . LYS B 2 43  ? -8.96987  17.07524  30.33788 1.000 269.33676 ? 44  LYS B HE3  1 
ATOM 1290 H HZ1  . LYS B 2 43  ? -9.81891  15.62799  31.88464 1.000 276.25668 ? 44  LYS B HZ1  1 
ATOM 1291 H HZ2  . LYS B 2 43  ? -10.71808 15.67192  30.74978 1.000 276.25668 ? 44  LYS B HZ2  1 
ATOM 1292 H HZ3  . LYS B 2 43  ? -11.05699 16.37512  31.97002 1.000 276.25668 ? 44  LYS B HZ3  1 
ATOM 1293 N N    . GLN B 2 44  ? -4.46671  15.64795  30.36427 1.000 170.81982 ? 45  GLN B N    1 
ATOM 1294 C CA   . GLN B 2 44  ? -3.77199  14.93856  29.29965 1.000 175.17087 ? 45  GLN B CA   1 
ATOM 1295 C C    . GLN B 2 44  ? -4.28072  15.33102  27.91647 1.000 189.39520 ? 45  GLN B C    1 
ATOM 1296 O O    . GLN B 2 44  ? -5.46206  15.63013  27.72267 1.000 187.49813 ? 45  GLN B O    1 
ATOM 1297 C CB   . GLN B 2 44  ? -3.96662  13.43729  29.49208 1.000 196.15234 ? 45  GLN B CB   1 
ATOM 1298 C CG   . GLN B 2 44  ? -3.01850  12.55937  28.71493 1.000 236.00483 ? 45  GLN B CG   1 
ATOM 1299 C CD   . GLN B 2 44  ? -3.25160  11.09179  28.99830 1.000 233.74753 ? 45  GLN B CD   1 
ATOM 1300 O OE1  . GLN B 2 44  ? -4.08208  10.73482  29.83487 1.000 206.51588 ? 45  GLN B OE1  1 
ATOM 1301 N NE2  . GLN B 2 44  ? -2.51518  10.23127  28.30770 1.000 231.10643 ? 45  GLN B NE2  1 
ATOM 1302 H H    . GLN B 2 44  ? -4.93319  15.12794  30.86585 1.000 207.52939 ? 45  GLN B H    1 
ATOM 1303 H HA   . GLN B 2 44  ? -2.82907  15.16332  29.33547 1.000 212.75065 ? 45  GLN B HA   1 
ATOM 1304 H HB2  . GLN B 2 44  ? -3.84677  13.23151  30.43240 1.000 237.92842 ? 45  GLN B HB2  1 
ATOM 1305 H HB3  . GLN B 2 44  ? -4.86722  13.20768  29.21439 1.000 237.92842 ? 45  GLN B HB3  1 
ATOM 1306 H HG2  . GLN B 2 44  ? -3.14861  12.71006  27.76558 1.000 285.75140 ? 45  GLN B HG2  1 
ATOM 1307 H HG3  . GLN B 2 44  ? -2.10612  12.77573  28.96321 1.000 285.75140 ? 45  GLN B HG3  1 
ATOM 1308 H HE21 . GLN B 2 44  ? -1.94205  10.51881  27.73460 1.000 279.87332 ? 45  GLN B HE21 1 
ATOM 1309 H HE22 . GLN B 2 44  ? -2.61089  9.38586   28.43309 1.000 279.87332 ? 45  GLN B HE22 1 
ATOM 1310 N N    . ARG B 2 45  ? -3.36465  15.32557  26.94493 1.000 173.14920 ? 46  ARG B N    1 
ATOM 1311 C CA   . ARG B 2 45  ? -3.75752  15.51513  25.55438 1.000 181.15444 ? 46  ARG B CA   1 
ATOM 1312 C C    . ARG B 2 45  ? -4.70588  14.41099  25.10153 1.000 155.57736 ? 46  ARG B C    1 
ATOM 1313 O O    . ARG B 2 45  ? -4.43180  13.21965  25.27209 1.000 169.57448 ? 46  ARG B O    1 
ATOM 1314 C CB   . ARG B 2 45  ? -2.52149  15.56300  24.64625 1.000 166.76106 ? 46  ARG B CB   1 
ATOM 1315 C CG   . ARG B 2 45  ? -2.80246  16.21936  23.28994 1.000 204.14135 ? 46  ARG B CG   1 
ATOM 1316 C CD   . ARG B 2 45  ? -1.74128  17.20028  22.76539 1.000 212.70148 ? 46  ARG B CD   1 
ATOM 1317 N NE   . ARG B 2 45  ? -0.39716  17.03930  23.31062 1.000 174.77412 ? 46  ARG B NE   1 
ATOM 1318 C CZ   . ARG B 2 45  ? 0.49430   18.01993  23.40186 1.000 142.19729 ? 46  ARG B CZ   1 
ATOM 1319 N NH1  . ARG B 2 45  ? 0.16888   19.27976  23.15602 1.000 152.94386 ? 46  ARG B NH1  1 
ATOM 1320 N NH2  . ARG B 2 45  ? 1.73559   17.73629  23.78574 1.000 153.15177 ? 46  ARG B NH2  1 
ATOM 1321 H H    . ARG B 2 45  ? -2.52045  15.21522  27.06636 1.000 210.32464 ? 46  ARG B H    1 
ATOM 1322 H HA   . ARG B 2 45  ? -4.22169  16.36316  25.47507 1.000 219.93094 ? 46  ARG B HA   1 
ATOM 1323 H HB2  . ARG B 2 45  ? -1.82551  16.07413  25.08813 1.000 202.65888 ? 46  ARG B HB2  1 
ATOM 1324 H HB3  . ARG B 2 45  ? -2.21511  14.65722  24.48316 1.000 202.65888 ? 46  ARG B HB3  1 
ATOM 1325 H HG2  . ARG B 2 45  ? -2.88986  15.51643  22.62725 1.000 247.51522 ? 46  ARG B HG2  1 
ATOM 1326 H HG3  . ARG B 2 45  ? -3.63400  16.71374  23.36082 1.000 247.51522 ? 46  ARG B HG3  1 
ATOM 1327 H HD2  . ARG B 2 45  ? -1.67489  17.09053  21.80391 1.000 257.78737 ? 46  ARG B HD2  1 
ATOM 1328 H HD3  . ARG B 2 45  ? -2.02972  18.10184  22.97725 1.000 257.78737 ? 46  ARG B HD3  1 
ATOM 1329 H HE   . ARG B 2 45  ? -0.16743  16.25938  23.59089 1.000 212.27454 ? 46  ARG B HE   1 
ATOM 1330 H HH11 . ARG B 2 45  ? -0.63668  19.47972  22.93089 1.000 186.07824 ? 46  ARG B HH11 1 
ATOM 1331 H HH12 . ARG B 2 45  ? 0.76311   19.89800  23.22149 1.000 186.07824 ? 46  ARG B HH12 1 
ATOM 1332 H HH21 . ARG B 2 45  ? 1.95349   16.92539  23.97166 1.000 186.32773 ? 46  ARG B HH21 1 
ATOM 1333 H HH22 . ARG B 2 45  ? 2.32039   18.36376  23.84805 1.000 186.32773 ? 46  ARG B HH22 1 
ATOM 1334 N N    . GLU B 2 46  ? -5.82177  14.82996  24.51450 1.000 146.29394 ? 47  GLU B N    1 
ATOM 1335 C CA   . GLU B 2 46  ? -6.89451  13.96382  24.04625 1.000 159.88034 ? 47  GLU B CA   1 
ATOM 1336 C C    . GLU B 2 46  ? -6.94216  14.02884  22.52598 1.000 156.25929 ? 47  GLU B C    1 
ATOM 1337 O O    . GLU B 2 46  ? -7.02298  15.12008  21.95471 1.000 168.51176 ? 47  GLU B O    1 
ATOM 1338 C CB   . GLU B 2 46  ? -8.23550  14.38016  24.65592 1.000 182.60536 ? 47  GLU B CB   1 
ATOM 1339 C CG   . GLU B 2 46  ? -9.44676  13.69488  24.04889 1.000 203.79073 ? 47  GLU B CG   1 
ATOM 1340 C CD   . GLU B 2 46  ? -10.74863 14.17918  24.65323 1.000 172.35817 ? 47  GLU B CD   1 
ATOM 1341 O OE1  . GLU B 2 46  ? -10.79192 15.33132  25.13242 1.000 194.32800 ? 47  GLU B OE1  1 
ATOM 1342 O OE2  . GLU B 2 46  ? -11.73100 13.40906  24.64465 1.000 149.36036 ? 47  GLU B OE2  1 
ATOM 1343 H H    . GLU B 2 46  ? -5.98886  15.66083  24.36843 1.000 178.09833 ? 47  GLU B H    1 
ATOM 1344 H HA   . GLU B 2 46  ? -6.72606  13.04495  24.30743 1.000 194.40201 ? 47  GLU B HA   1 
ATOM 1345 H HB2  . GLU B 2 46  ? -8.22317  14.16782  25.60232 1.000 221.67203 ? 47  GLU B HB2  1 
ATOM 1346 H HB3  . GLU B 2 46  ? -8.34734  15.33565  24.53172 1.000 221.67203 ? 47  GLU B HB3  1 
ATOM 1347 H HG2  . GLU B 2 46  ? -9.47044  13.87739  23.09651 1.000 247.09448 ? 47  GLU B HG2  1 
ATOM 1348 H HG3  . GLU B 2 46  ? -9.38061  12.73933  24.20202 1.000 247.09448 ? 47  GLU B HG3  1 
ATOM 1349 N N    . LEU B 2 47  ? -6.89983  12.87279  21.87193 1.000 157.51175 ? 48  LEU B N    1 
ATOM 1350 C CA   . LEU B 2 47  ? -7.20017  12.83319  20.44690 1.000 155.33829 ? 48  LEU B CA   1 
ATOM 1351 C C    . LEU B 2 47  ? -8.66708  13.16247  20.19186 1.000 168.55144 ? 48  LEU B C    1 
ATOM 1352 O O    . LEU B 2 47  ? -9.56309  12.63448  20.85702 1.000 157.70738 ? 48  LEU B O    1 
ATOM 1353 C CB   . LEU B 2 47  ? -6.86425  11.45171  19.88702 1.000 142.02014 ? 48  LEU B CB   1 
ATOM 1354 C CG   . LEU B 2 47  ? -7.00105  11.23494  18.37871 1.000 150.01321 ? 48  LEU B CG   1 
ATOM 1355 C CD1  . LEU B 2 47  ? -6.01245  12.07999  17.60220 1.000 155.97492 ? 48  LEU B CD1  1 
ATOM 1356 C CD2  . LEU B 2 47  ? -6.81023  9.76119   18.05674 1.000 199.20560 ? 48  LEU B CD2  1 
ATOM 1357 H H    . LEU B 2 47  ? -6.70386  12.11276  22.22343 1.000 191.55970 ? 48  LEU B H    1 
ATOM 1358 H HA   . LEU B 2 47  ? -6.66253  13.49721  19.98763 1.000 188.95155 ? 48  LEU B HA   1 
ATOM 1359 H HB2  . LEU B 2 47  ? -5.94101  11.25875  20.11347 1.000 172.96977 ? 48  LEU B HB2  1 
ATOM 1360 H HB3  . LEU B 2 47  ? -7.45200  10.80965  20.31505 1.000 172.96977 ? 48  LEU B HB3  1 
ATOM 1361 H HG   . LEU B 2 47  ? -7.88908  11.50920  18.10107 1.000 182.56146 ? 48  LEU B HG   1 
ATOM 1362 H HD11 . LEU B 2 47  ? -6.17761  13.01622  17.79477 1.000 189.71550 ? 48  LEU B HD11 1 
ATOM 1363 H HD12 . LEU B 2 47  ? -6.12939  11.91166  16.65410 1.000 189.71550 ? 48  LEU B HD12 1 
ATOM 1364 H HD13 . LEU B 2 47  ? -5.11201  11.84062  17.87205 1.000 189.71550 ? 48  LEU B HD13 1 
ATOM 1365 H HD21 . LEU B 2 47  ? -6.88457  9.63522   17.09783 1.000 241.59232 ? 48  LEU B HD21 1 
ATOM 1366 H HD22 . LEU B 2 47  ? -5.93182  9.48289   18.35980 1.000 241.59232 ? 48  LEU B HD22 1 
ATOM 1367 H HD23 . LEU B 2 47  ? -7.49540  9.24719   18.51199 1.000 241.59232 ? 48  LEU B HD23 1 
ATOM 1368 N N    . VAL B 2 48  ? -8.90087  14.04633  19.22325 1.000 155.21971 ? 49  VAL B N    1 
ATOM 1369 C CA   . VAL B 2 48  ? -10.22668 14.56452  18.90569 1.000 110.39383 ? 49  VAL B CA   1 
ATOM 1370 C C    . VAL B 2 48  ? -10.73973 13.99460  17.58916 1.000 122.52924 ? 49  VAL B C    1 
ATOM 1371 O O    . VAL B 2 48  ? -11.86906 13.51071  17.51054 1.000 147.73035 ? 49  VAL B O    1 
ATOM 1372 C CB   . VAL B 2 48  ? -10.22470 16.11134  18.87163 1.000 185.69060 ? 49  VAL B CB   1 
ATOM 1373 C CG1  . VAL B 2 48  ? -11.57070 16.64423  18.37797 1.000 172.46256 ? 49  VAL B CG1  1 
ATOM 1374 C CG2  . VAL B 2 48  ? -9.91066  16.67698  20.24495 1.000 189.13703 ? 49  VAL B CG2  1 
ATOM 1375 H H    . VAL B 2 48  ? -8.28398  14.37091  18.71957 1.000 188.80925 ? 49  VAL B H    1 
ATOM 1376 H HA   . VAL B 2 48  ? -10.83800 14.28598  19.60540 1.000 135.01820 ? 49  VAL B HA   1 
ATOM 1377 H HB   . VAL B 2 48  ? -9.53560  16.40312  18.25445 1.000 225.37433 ? 49  VAL B HB   1 
ATOM 1378 H HG11 . VAL B 2 48  ? -11.59008 17.60731  18.49201 1.000 209.50068 ? 49  VAL B HG11 1 
ATOM 1379 H HG12 . VAL B 2 48  ? -12.28147 16.23541  18.89620 1.000 209.50068 ? 49  VAL B HG12 1 
ATOM 1380 H HG13 . VAL B 2 48  ? -11.67427 16.42006  17.43993 1.000 209.50068 ? 49  VAL B HG13 1 
ATOM 1381 H HG21 . VAL B 2 48  ? -9.03720  16.36100  20.52444 1.000 229.51004 ? 49  VAL B HG21 1 
ATOM 1382 H HG22 . VAL B 2 48  ? -9.91167  17.64570  20.19527 1.000 229.51004 ? 49  VAL B HG22 1 
ATOM 1383 H HG23 . VAL B 2 48  ? -10.58714 16.37723  20.87218 1.000 229.51004 ? 49  VAL B HG23 1 
ATOM 1384 N N    . ALA B 2 49  ? -9.91815  14.03624  16.54289 1.000 145.54445 ? 50  ALA B N    1 
ATOM 1385 C CA   . ALA B 2 49  ? -10.40656 13.62971  15.23015 1.000 127.88082 ? 50  ALA B CA   1 
ATOM 1386 C C    . ALA B 2 49  ? -9.23112  13.19734  14.37126 1.000 113.66763 ? 50  ALA B C    1 
ATOM 1387 O O    . ALA B 2 49  ? -8.11216  13.67769  14.55010 1.000 129.47409 ? 50  ALA B O    1 
ATOM 1388 C CB   . ALA B 2 49  ? -11.18020 14.76172  14.54155 1.000 124.45140 ? 50  ALA B CB   1 
ATOM 1389 H H    . ALA B 2 49  ? -9.09657  14.28922  16.56762 1.000 177.19894 ? 50  ALA B H    1 
ATOM 1390 H HA   . ALA B 2 49  ? -11.00067 12.86998  15.33373 1.000 156.00259 ? 50  ALA B HA   1 
ATOM 1391 H HB1  . ALA B 2 49  ? -11.88489 15.06822  15.13347 1.000 151.88729 ? 50  ALA B HB1  1 
ATOM 1392 H HB2  . ALA B 2 49  ? -11.56403 14.42561  13.71657 1.000 151.88729 ? 50  ALA B HB2  1 
ATOM 1393 H HB3  . ALA B 2 49  ? -10.56937 15.49034  14.34943 1.000 151.88729 ? 50  ALA B HB3  1 
ATOM 1394 N N    . ILE B 2 50  ? -9.48794  12.27103  13.45109 1.000 108.84736 ? 51  ILE B N    1 
ATOM 1395 C CA   . ILE B 2 50  ? -8.46955  11.83548  12.50251 1.000 141.79635 ? 51  ILE B CA   1 
ATOM 1396 C C    . ILE B 2 50  ? -9.07872  11.76063  11.11030 1.000 135.79089 ? 51  ILE B C    1 
ATOM 1397 O O    . ILE B 2 50  ? -10.23259 11.34058  10.94721 1.000 160.35341 ? 51  ILE B O    1 
ATOM 1398 C CB   . ILE B 2 50  ? -7.86584  10.47452  12.90455 1.000 139.04731 ? 51  ILE B CB   1 
ATOM 1399 C CG1  . ILE B 2 50  ? -8.87008  9.34944   12.66019 1.000 105.87586 ? 51  ILE B CG1  1 
ATOM 1400 C CG2  . ILE B 2 50  ? -7.46890  10.49299  14.36609 1.000 149.16407 ? 51  ILE B CG2  1 
ATOM 1401 C CD1  . ILE B 2 50  ? -8.64852  8.63731   11.35165 1.000 144.59491 ? 51  ILE B CD1  1 
ATOM 1402 H H    . ILE B 2 50  ? -10.24786 11.87950  13.35717 1.000 133.16243 ? 51  ILE B H    1 
ATOM 1403 H HA   . ILE B 2 50  ? -7.76004  12.49661  12.48274 1.000 172.70123 ? 51  ILE B HA   1 
ATOM 1404 H HB   . ILE B 2 50  ? -7.07982  10.31828  12.35804 1.000 169.40237 ? 51  ILE B HB   1 
ATOM 1405 H HG12 . ILE B 2 50  ? -8.79130  8.69666   13.37333 1.000 129.59664 ? 51  ILE B HG12 1 
ATOM 1406 H HG13 . ILE B 2 50  ? -9.76517  9.72308   12.64984 1.000 129.59664 ? 51  ILE B HG13 1 
ATOM 1407 H HG21 . ILE B 2 50  ? -6.93139  9.70851   14.55729 1.000 181.54249 ? 51  ILE B HG21 1 
ATOM 1408 H HG22 . ILE B 2 50  ? -8.27112  10.48522  14.91132 1.000 181.54249 ? 51  ILE B HG22 1 
ATOM 1409 H HG23 . ILE B 2 50  ? -6.95591  11.29682  14.54387 1.000 181.54249 ? 51  ILE B HG23 1 
ATOM 1410 H HD11 . ILE B 2 50  ? -9.31005  7.93397   11.25892 1.000 176.05950 ? 51  ILE B HD11 1 
ATOM 1411 H HD12 . ILE B 2 50  ? -8.73930  9.27455   10.62599 1.000 176.05950 ? 51  ILE B HD12 1 
ATOM 1412 H HD13 . ILE B 2 50  ? -7.75686  8.25545   11.34695 1.000 176.05950 ? 51  ILE B HD13 1 
ATOM 1413 N N    . ILE B 2 51  ? -8.26947  12.11024  10.10615 1.000 137.58569 ? 52  ILE B N    1 
ATOM 1414 C CA   . ILE B 2 51  ? -8.57430  11.88667  8.69635  1.000 159.12889 ? 52  ILE B CA   1 
ATOM 1415 C C    . ILE B 2 51  ? -7.41101  11.12793  8.06961  1.000 184.89373 ? 52  ILE B C    1 
ATOM 1416 O O    . ILE B 2 51  ? -6.25362  11.54065  8.19551  1.000 193.56087 ? 52  ILE B O    1 
ATOM 1417 C CB   . ILE B 2 51  ? -8.83820  13.20182  7.93540  1.000 143.45759 ? 52  ILE B CB   1 
ATOM 1418 C CG1  . ILE B 2 51  ? -9.35662  12.89633  6.52586  1.000 150.74663 ? 52  ILE B CG1  1 
ATOM 1419 C CG2  . ILE B 2 51  ? -7.58302  14.05825  7.86277  1.000 152.32556 ? 52  ILE B CG2  1 
ATOM 1420 C CD1  . ILE B 2 51  ? -9.99926  14.07962  5.83330  1.000 205.18870 ? 52  ILE B CD1  1 
ATOM 1421 H H    . ILE B 2 51  ? -7.50881  12.49347  10.22503 1.000 167.64843 ? 52  ILE B H    1 
ATOM 1422 H HA   . ILE B 2 51  ? -9.37229  11.33927  8.62962  1.000 193.50027 ? 52  ILE B HA   1 
ATOM 1423 H HB   . ILE B 2 51  ? -9.51298  13.70021  8.42241  1.000 174.69472 ? 52  ILE B HB   1 
ATOM 1424 H HG12 . ILE B 2 51  ? -8.61189  12.60313  5.97787  1.000 183.44156 ? 52  ILE B HG12 1 
ATOM 1425 H HG13 . ILE B 2 51  ? -10.02189 12.19293  6.58536  1.000 183.44156 ? 52  ILE B HG13 1 
ATOM 1426 H HG21 . ILE B 2 51  ? -7.20382  14.13884  8.75194  1.000 185.33628 ? 52  ILE B HG21 1 
ATOM 1427 H HG22 . ILE B 2 51  ? -6.94493  13.63360  7.26828  1.000 185.33628 ? 52  ILE B HG22 1 
ATOM 1428 H HG23 . ILE B 2 51  ? -7.81862  14.93566  7.52287  1.000 185.33628 ? 52  ILE B HG23 1 
ATOM 1429 H HD11 . ILE B 2 51  ? -10.39668 13.78050  5.00055  1.000 248.77205 ? 52  ILE B HD11 1 
ATOM 1430 H HD12 . ILE B 2 51  ? -10.68365 14.45071  6.41192  1.000 248.77205 ? 52  ILE B HD12 1 
ATOM 1431 H HD13 . ILE B 2 51  ? -9.31952  14.74802  5.65411  1.000 248.77205 ? 52  ILE B HD13 1 
ATOM 1432 N N    . THR B 2 52  ? -7.71984  10.01785  7.40828  1.000 171.75212 ? 53  THR B N    1 
ATOM 1433 C CA   . THR B 2 52  ? -6.73392  9.15340   6.77992  1.000 138.87393 ? 53  THR B CA   1 
ATOM 1434 C C    . THR B 2 52  ? -6.29536  9.70221   5.42584  1.000 175.19896 ? 53  THR B C    1 
ATOM 1435 O O    . THR B 2 52  ? -6.88671  10.63265  4.87605  1.000 210.03958 ? 53  THR B O    1 
ATOM 1436 C CB   . THR B 2 52  ? -7.30485  7.76143   6.57501  1.000 146.19930 ? 53  THR B CB   1 
ATOM 1437 O OG1  . THR B 2 52  ? -8.31519  7.84237   5.56257  1.000 187.32396 ? 53  THR B OG1  1 
ATOM 1438 C CG2  . THR B 2 52  ? -7.89328  7.22896   7.87432  1.000 180.19698 ? 53  THR B CG2  1 
ATOM 1439 H H    . THR B 2 52  ? -8.52511  9.73375   7.30615  1.000 208.64814 ? 53  THR B H    1 
ATOM 1440 H HA   . THR B 2 52  ? -5.96105  9.10801   7.36432  1.000 169.19432 ? 53  THR B HA   1 
ATOM 1441 H HB   . THR B 2 52  ? -6.61293  7.13991   6.29958  1.000 177.98476 ? 53  THR B HB   1 
ATOM 1442 H HG1  . THR B 2 52  ? -8.55859  7.07063   5.33724  1.000 227.33435 ? 53  THR B HG1  1 
ATOM 1443 H HG21 . THR B 2 52  ? -8.12747  6.29307   7.77347  1.000 218.78198 ? 53  THR B HG21 1 
ATOM 1444 H HG22 . THR B 2 52  ? -8.69075  7.72970   8.10712  1.000 218.78198 ? 53  THR B HG22 1 
ATOM 1445 H HG23 . THR B 2 52  ? -7.24628  7.31602   8.59176  1.000 218.78198 ? 53  THR B HG23 1 
ATOM 1446 N N    . THR B 2 53  ? -5.23028  9.09829   4.89057  1.000 178.83630 ? 54  THR B N    1 
ATOM 1447 C CA   . THR B 2 53  ? -4.72605  9.48258   3.57617  1.000 187.74766 ? 54  THR B CA   1 
ATOM 1448 C C    . THR B 2 53  ? -5.82237  9.49336   2.51880  1.000 166.58116 ? 54  THR B C    1 
ATOM 1449 O O    . THR B 2 53  ? -5.88760  10.40959  1.69407  1.000 173.01261 ? 54  THR B O    1 
ATOM 1450 C CB   . THR B 2 53  ? -3.62570  8.50556   3.15207  1.000 194.51374 ? 54  THR B CB   1 
ATOM 1451 O OG1  . THR B 2 53  ? -2.54317  8.55437   4.08898  1.000 209.71117 ? 54  THR B OG1  1 
ATOM 1452 C CG2  . THR B 2 53  ? -3.10940  8.82825   1.74650  1.000 189.29593 ? 54  THR B CG2  1 
ATOM 1453 H H    . THR B 2 53  ? -4.78536  8.46641   5.26789  1.000 217.14916 ? 54  THR B H    1 
ATOM 1454 H HA   . THR B 2 53  ? -4.36236  10.37954  3.64017  1.000 227.84279 ? 54  THR B HA   1 
ATOM 1455 H HB   . THR B 2 53  ? -3.99149  7.60737   3.13328  1.000 235.96210 ? 54  THR B HB   1 
ATOM 1456 H HG1  . THR B 2 53  ? -1.82328  8.71732   3.68798  1.000 254.19900 ? 54  THR B HG1  1 
ATOM 1457 H HG21 . THR B 2 53  ? -2.31190  8.30900   1.55868  1.000 229.70072 ? 54  THR B HG21 1 
ATOM 1458 H HG22 . THR B 2 53  ? -3.78732  8.61377   1.08670  1.000 229.70072 ? 54  THR B HG22 1 
ATOM 1459 H HG23 . THR B 2 53  ? -2.89352  9.77164   1.68083  1.000 229.70072 ? 54  THR B HG23 1 
ATOM 1460 N N    . PHE B 2 54  ? -6.66513  8.46148   2.49708  1.000 149.18813 ? 55  PHE B N    1 
ATOM 1461 C CA   . PHE B 2 54  ? -7.73676  8.34107   1.51682  1.000 138.87404 ? 55  PHE B CA   1 
ATOM 1462 C C    . PHE B 2 54  ? -9.09185  8.82988   2.02920  1.000 179.80517 ? 55  PHE B C    1 
ATOM 1463 O O    . PHE B 2 54  ? -10.12896 8.46604   1.46457  1.000 178.78632 ? 55  PHE B O    1 
ATOM 1464 C CB   . PHE B 2 54  ? -7.77221  6.90791   0.99521  1.000 189.50119 ? 55  PHE B CB   1 
ATOM 1465 C CG   . PHE B 2 54  ? -6.51552  6.54386   0.25293  1.000 194.59161 ? 55  PHE B CG   1 
ATOM 1466 C CD1  . PHE B 2 54  ? -6.28010  7.06618   -1.00925 1.000 190.05459 ? 55  PHE B CD1  1 
ATOM 1467 C CD2  . PHE B 2 54  ? -5.54879  5.73342   0.82668  1.000 165.09023 ? 55  PHE B CD2  1 
ATOM 1468 C CE1  . PHE B 2 54  ? -5.12359  6.76442   -1.69717 1.000 178.10299 ? 55  PHE B CE1  1 
ATOM 1469 C CE2  . PHE B 2 54  ? -4.38693  5.42286   0.13612  1.000 173.59877 ? 55  PHE B CE2  1 
ATOM 1470 C CZ   . PHE B 2 54  ? -4.17309  5.94620   -1.12423 1.000 170.77616 ? 55  PHE B CZ   1 
ATOM 1471 H H    . PHE B 2 54  ? -6.63338  7.80603   3.05294  1.000 181.57136 ? 55  PHE B H    1 
ATOM 1472 H HA   . PHE B 2 54  ? -7.54829  8.91532   0.75813  1.000 169.19446 ? 55  PHE B HA   1 
ATOM 1473 H HB2  . PHE B 2 54  ? -7.86889  6.29906   1.74412  1.000 229.94703 ? 55  PHE B HB2  1 
ATOM 1474 H HB3  . PHE B 2 54  ? -8.52219  6.80876   0.38809  1.000 229.94703 ? 55  PHE B HB3  1 
ATOM 1475 H HD1  . PHE B 2 54  ? -6.91110  7.62817   -1.39773 1.000 230.61111 ? 55  PHE B HD1  1 
ATOM 1476 H HD2  . PHE B 2 54  ? -5.68041  5.39468   1.68274  1.000 200.65388 ? 55  PHE B HD2  1 
ATOM 1477 H HE1  . PHE B 2 54  ? -4.98467  7.11303   -2.54810 1.000 216.26919 ? 55  PHE B HE1  1 
ATOM 1478 H HE2  . PHE B 2 54  ? -3.75227  4.86271   0.52126  1.000 210.86413 ? 55  PHE B HE2  1 
ATOM 1479 H HZ   . PHE B 2 54  ? -3.39019  5.74722   -1.58507 1.000 207.47699 ? 55  PHE B HZ   1 
ATOM 1480 N N    . GLY B 2 55  ? -9.10252  9.63742   3.08636  1.000 200.41604 ? 56  GLY B N    1 
ATOM 1481 C CA   . GLY B 2 55  ? -10.26247 10.43409  3.43748  1.000 177.81822 ? 56  GLY B CA   1 
ATOM 1482 C C    . GLY B 2 55  ? -11.27004 9.83194   4.39256  1.000 169.99045 ? 56  GLY B C    1 
ATOM 1483 O O    . GLY B 2 55  ? -12.31095 10.45734  4.62584  1.000 203.25672 ? 56  GLY B O    1 
ATOM 1484 H H    . GLY B 2 55  ? -8.43726  9.73983   3.62165  1.000 243.04485 ? 56  GLY B H    1 
ATOM 1485 H HA2  . GLY B 2 55  ? -9.94780  11.25826  3.84074  1.000 215.92747 ? 56  GLY B HA2  1 
ATOM 1486 H HA3  . GLY B 2 55  ? -10.73897 10.64468  2.61925  1.000 215.92747 ? 56  GLY B HA3  1 
ATOM 1487 N N    . SER B 2 56  ? -11.01225 8.65772   4.96020  1.000 174.03558 ? 57  SER B N    1 
ATOM 1488 C CA   . SER B 2 56  ? -11.87742 8.17691   6.02893  1.000 167.94486 ? 57  SER B CA   1 
ATOM 1489 C C    . SER B 2 56  ? -11.65078 9.00866   7.28634  1.000 153.99218 ? 57  SER B C    1 
ATOM 1490 O O    . SER B 2 56  ? -10.56994 9.55783   7.50423  1.000 154.37820 ? 57  SER B O    1 
ATOM 1491 C CB   . SER B 2 56  ? -11.62049 6.69925   6.31612  1.000 166.39897 ? 57  SER B CB   1 
ATOM 1492 O OG   . SER B 2 56  ? -11.91949 5.90451   5.18238  1.000 194.55779 ? 57  SER B OG   1 
ATOM 1493 H H    . SER B 2 56  ? -10.36148 8.13612   4.75036  1.000 211.38830 ? 57  SER B H    1 
ATOM 1494 H HA   . SER B 2 56  ? -12.80648 8.25922   5.76251  1.000 204.07944 ? 57  SER B HA   1 
ATOM 1495 H HB2  . SER B 2 56  ? -10.68587 6.58057   6.54700  1.000 202.22437 ? 57  SER B HB2  1 
ATOM 1496 H HB3  . SER B 2 56  ? -12.18293 6.41902   7.05506  1.000 202.22437 ? 57  SER B HB3  1 
ATOM 1497 H HG   . SER B 2 56  ? -12.73623 5.70829   5.17638  1.000 236.01495 ? 57  SER B HG   1 
ATOM 1498 N N    . THR B 2 57  ? -12.68891 9.11477   8.11216  1.000 156.67512 ? 58  THR B N    1 
ATOM 1499 C CA   . THR B 2 57  ? -12.63981 9.94092   9.30947  1.000 150.35370 ? 58  THR B CA   1 
ATOM 1500 C C    . THR B 2 57  ? -13.06033 9.14285   10.53353 1.000 133.55866 ? 58  THR B C    1 
ATOM 1501 O O    . THR B 2 57  ? -13.85099 8.19907   10.44444 1.000 148.64167 ? 58  THR B O    1 
ATOM 1502 C CB   . THR B 2 57  ? -13.54067 11.18454  9.19132  1.000 132.24099 ? 58  THR B CB   1 
ATOM 1503 O OG1  . THR B 2 57  ? -14.91212 10.78465  9.07806  1.000 163.10376 ? 58  THR B OG1  1 
ATOM 1504 C CG2  . THR B 2 57  ? -13.15163 12.02461  7.98558  1.000 168.79086 ? 58  THR B CG2  1 
ATOM 1505 H H    . THR B 2 57  ? -13.44002 8.71218   7.99660  1.000 190.55574 ? 58  THR B H    1 
ATOM 1506 H HA   . THR B 2 57  ? -11.72263 10.22977  9.43691  1.000 182.97005 ? 58  THR B HA   1 
ATOM 1507 H HB   . THR B 2 57  ? -13.43268 11.73143  9.98514  1.000 161.23479 ? 58  THR B HB   1 
ATOM 1508 H HG1  . THR B 2 57  ? -15.39346 11.45282  8.91238  1.000 198.27011 ? 58  THR B HG1  1 
ATOM 1509 H HG21 . THR B 2 57  ? -13.65415 12.85430  7.98323  1.000 205.09464 ? 58  THR B HG21 1 
ATOM 1510 H HG22 . THR B 2 57  ? -13.34181 11.53908  7.16766  1.000 205.09464 ? 58  THR B HG22 1 
ATOM 1511 H HG23 . THR B 2 57  ? -12.20423 12.23048  8.01642  1.000 205.09464 ? 58  THR B HG23 1 
ATOM 1512 N N    . ASN B 2 58  ? -12.52341 9.54339   11.68424 1.000 140.14994 ? 59  ASN B N    1 
ATOM 1513 C CA   . ASN B 2 58  ? -13.05197 9.06592   12.95740 1.000 136.18881 ? 59  ASN B CA   1 
ATOM 1514 C C    . ASN B 2 58  ? -12.92360 10.15508  14.00857 1.000 143.28853 ? 59  ASN B C    1 
ATOM 1515 O O    . ASN B 2 58  ? -12.07493 11.04644  13.91646 1.000 180.78277 ? 59  ASN B O    1 
ATOM 1516 C CB   . ASN B 2 58  ? -12.34425 7.80357   13.47480 1.000 132.66768 ? 59  ASN B CB   1 
ATOM 1517 C CG   . ASN B 2 58  ? -13.15753 6.53863   13.25938 1.000 150.93463 ? 59  ASN B CG   1 
ATOM 1518 O OD1  . ASN B 2 58  ? -14.38365 6.57991   13.17530 1.000 180.87967 ? 59  ASN B OD1  1 
ATOM 1519 N ND2  . ASN B 2 58  ? -12.48096 5.39766   13.26184 1.000 150.54742 ? 59  ASN B ND2  1 
ATOM 1520 H H    . ASN B 2 58  ? -11.85935 10.08561  11.75220 1.000 170.72553 ? 59  ASN B H    1 
ATOM 1521 H HA   . ASN B 2 58  ? -13.98912 8.85795   12.81814 1.000 165.97218 ? 59  ASN B HA   1 
ATOM 1522 H HB2  . ASN B 2 58  ? -11.50097 7.70044   13.00667 1.000 161.74682 ? 59  ASN B HB2  1 
ATOM 1523 H HB3  . ASN B 2 58  ? -12.18563 7.89875   14.42700 1.000 161.74682 ? 59  ASN B HB3  1 
ATOM 1524 H HD21 . ASN B 2 58  ? -11.62929 5.40301   13.38111 1.000 183.20251 ? 59  ASN B HD21 1 
ATOM 1525 H HD22 . ASN B 2 58  ? -12.89400 4.65257   13.14416 1.000 183.20251 ? 59  ASN B HD22 1 
ATOM 1526 N N    . TYR B 2 59  ? -13.79730 10.06664  15.01231 1.000 113.03633 ? 60  TYR B N    1 
ATOM 1527 C CA   . TYR B 2 59  ? -13.93589 11.08721  16.03742 1.000 129.82626 ? 60  TYR B CA   1 
ATOM 1528 C C    . TYR B 2 59  ? -13.92915 10.43437  17.41165 1.000 158.98877 ? 60  TYR B C    1 
ATOM 1529 O O    . TYR B 2 59  ? -14.44168 9.32709   17.59505 1.000 172.35735 ? 60  TYR B O    1 
ATOM 1530 C CB   . TYR B 2 59  ? -15.22150 11.88982  15.82277 1.000 112.84175 ? 60  TYR B CB   1 
ATOM 1531 C CG   . TYR B 2 59  ? -15.26196 12.52364  14.45554 1.000 129.77537 ? 60  TYR B CG   1 
ATOM 1532 C CD1  . TYR B 2 59  ? -14.65532 13.74894  14.21993 1.000 129.38846 ? 60  TYR B CD1  1 
ATOM 1533 C CD2  . TYR B 2 59  ? -15.82927 11.85500  13.38018 1.000 154.82883 ? 60  TYR B CD2  1 
ATOM 1534 C CE1  . TYR B 2 59  ? -14.67054 14.32134  12.96375 1.000 151.01527 ? 60  TYR B CE1  1 
ATOM 1535 C CE2  . TYR B 2 59  ? -15.84902 12.41745  12.12175 1.000 142.90786 ? 60  TYR B CE2  1 
ATOM 1536 C CZ   . TYR B 2 59  ? -15.27045 13.65087  11.91920 1.000 146.71381 ? 60  TYR B CZ   1 
ATOM 1537 O OH   . TYR B 2 59  ? -15.26851 14.19937  10.65944 1.000 162.94126 ? 60  TYR B OH   1 
ATOM 1538 H H    . TYR B 2 59  ? -14.33415 9.40338   15.11945 1.000 138.18920 ? 60  TYR B H    1 
ATOM 1539 H HA   . TYR B 2 59  ? -13.18620 11.70208  16.00946 1.000 158.33711 ? 60  TYR B HA   1 
ATOM 1540 H HB2  . TYR B 2 59  ? -15.98556 11.29820  15.90707 1.000 137.95570 ? 60  TYR B HB2  1 
ATOM 1541 H HB3  . TYR B 2 59  ? -15.27291 12.59480  16.48705 1.000 137.95570 ? 60  TYR B HB3  1 
ATOM 1542 H HD1  . TYR B 2 59  ? -14.23163 14.19177  14.91943 1.000 157.81176 ? 60  TYR B HD1  1 
ATOM 1543 H HD2  . TYR B 2 59  ? -16.20247 11.01320  13.51060 1.000 188.34020 ? 60  TYR B HD2  1 
ATOM 1544 H HE1  . TYR B 2 59  ? -14.27897 15.15310  12.82321 1.000 183.76392 ? 60  TYR B HE1  1 
ATOM 1545 H HE2  . TYR B 2 59  ? -16.25044 11.96696  11.41407 1.000 174.03504 ? 60  TYR B HE2  1 
ATOM 1546 H HH   . TYR B 2 59  ? -15.69955 13.70826  10.13160 1.000 198.07512 ? 60  TYR B HH   1 
ATOM 1547 N N    . ALA B 2 60  ? -13.37161 11.14820  18.38384 1.000 165.26826 ? 61  ALA B N    1 
ATOM 1548 C CA   . ALA B 2 60  ? -13.53456 10.77491  19.77793 1.000 158.30940 ? 61  ALA B CA   1 
ATOM 1549 C C    . ALA B 2 60  ? -15.00643 10.83956  20.17360 1.000 165.41121 ? 61  ALA B C    1 
ATOM 1550 O O    . ALA B 2 60  ? -15.81767 11.53194  19.55428 1.000 171.93275 ? 61  ALA B O    1 
ATOM 1551 C CB   . ALA B 2 60  ? -12.69950 11.68517  20.67769 1.000 157.69457 ? 61  ALA B CB   1 
ATOM 1552 H H    . ALA B 2 60  ? -12.89442 11.85292  18.26031 1.000 200.86751 ? 61  ALA B H    1 
ATOM 1553 H HA   . ALA B 2 60  ? -13.22550 9.86511   19.91075 1.000 192.51688 ? 61  ALA B HA   1 
ATOM 1554 H HB1  . ALA B 2 60  ? -11.76928 11.62780  20.40879 1.000 191.77908 ? 61  ALA B HB1  1 
ATOM 1555 H HB2  . ALA B 2 60  ? -12.79631 11.39446  21.59802 1.000 191.77908 ? 61  ALA B HB2  1 
ATOM 1556 H HB3  . ALA B 2 60  ? -13.01521 12.59756  20.58405 1.000 191.77908 ? 61  ALA B HB3  1 
ATOM 1557 N N    . ASP B 2 61  ? -15.35370 10.06878  21.20510 1.000 155.49185 ? 62  ASP B N    1 
ATOM 1558 C CA   . ASP B 2 61  ? -16.73457 10.04035  21.67262 1.000 198.65805 ? 62  ASP B CA   1 
ATOM 1559 C C    . ASP B 2 61  ? -17.20579 11.41219  22.13794 1.000 224.50582 ? 62  ASP B C    1 
ATOM 1560 O O    . ASP B 2 61  ? -18.39371 11.73216  22.01645 1.000 226.33744 ? 62  ASP B O    1 
ATOM 1561 C CB   . ASP B 2 61  ? -16.87396 9.02928   22.81088 1.000 215.36419 ? 62  ASP B CB   1 
ATOM 1562 C CG   . ASP B 2 61  ? -16.73615 7.59596   22.33883 1.000 250.96082 ? 62  ASP B CG   1 
ATOM 1563 O OD1  . ASP B 2 61  ? -16.81287 7.36083   21.11495 1.000 263.22952 ? 62  ASP B OD1  1 
ATOM 1564 O OD2  . ASP B 2 61  ? -16.54890 6.70376   23.19306 1.000 261.36724 ? 62  ASP B OD2  1 
ATOM 1565 H H    . ASP B 2 61  ? -14.81597 9.56102   21.64398 1.000 189.13583 ? 62  ASP B H    1 
ATOM 1566 H HA   . ASP B 2 61  ? -17.30375 9.76188   20.93819 1.000 240.93527 ? 62  ASP B HA   1 
ATOM 1567 H HB2  . ASP B 2 61  ? -16.18155 9.19653   23.46928 1.000 260.98263 ? 62  ASP B HB2  1 
ATOM 1568 H HB3  . ASP B 2 61  ? -17.74912 9.12884   23.21718 1.000 260.98263 ? 62  ASP B HB3  1 
ATOM 1569 N N    . SER B 2 62  ? -16.30010 12.23286  22.67585 1.000 226.34888 ? 63  SER B N    1 
ATOM 1570 C CA   . SER B 2 62  ? -16.66666 13.59151  23.06048 1.000 200.97879 ? 63  SER B CA   1 
ATOM 1571 C C    . SER B 2 62  ? -17.12309 14.44372  21.88194 1.000 209.84808 ? 63  SER B C    1 
ATOM 1572 O O    . SER B 2 62  ? -17.86370 15.41032  22.08879 1.000 262.23001 ? 63  SER B O    1 
ATOM 1573 C CB   . SER B 2 62  ? -15.48653 14.27292  23.75610 1.000 180.29396 ? 63  SER B CB   1 
ATOM 1574 O OG   . SER B 2 62  ? -14.34824 14.31315  22.91241 1.000 224.97522 ? 63  SER B OG   1 
ATOM 1575 H H    . SER B 2 62  ? -15.47841 12.02796  22.82563 1.000 274.16427 ? 63  SER B H    1 
ATOM 1576 H HA   . SER B 2 62  ? -17.40669 13.53649  23.68517 1.000 243.72015 ? 63  SER B HA   1 
ATOM 1577 H HB2  . SER B 2 62  ? -15.73906 15.18061  23.98684 1.000 218.89835 ? 63  SER B HB2  1 
ATOM 1578 H HB3  . SER B 2 62  ? -15.26524 13.77582  24.55911 1.000 218.89835 ? 63  SER B HB3  1 
ATOM 1579 H HG   . SER B 2 62  ? -13.64780 14.33230  23.37568 1.000 272.51587 ? 63  SER B HG   1 
ATOM 1580 N N    . ALA B 2 63  ? -16.69957 14.12716  20.65518 1.000 195.73793 ? 64  ALA B N    1 
ATOM 1581 C CA   . ALA B 2 63  ? -17.21358 14.86563  19.50480 1.000 196.66830 ? 64  ALA B CA   1 
ATOM 1582 C C    . ALA B 2 63  ? -18.68238 14.55078  19.25311 1.000 195.05631 ? 64  ALA B C    1 
ATOM 1583 O O    . ALA B 2 63  ? -19.47041 15.45309  18.95031 1.000 199.70205 ? 64  ALA B O    1 
ATOM 1584 C CB   . ALA B 2 63  ? -16.38373 14.54574  18.26382 1.000 141.19061 ? 64  ALA B CB   1 
ATOM 1585 H H    . ALA B 2 63  ? -16.13257 13.50788  20.46915 1.000 237.43112 ? 64  ALA B H    1 
ATOM 1586 H HA   . ALA B 2 63  ? -17.13526 15.81510  19.68719 1.000 238.54756 ? 64  ALA B HA   1 
ATOM 1587 H HB1  . ALA B 2 63  ? -15.45139 14.73909  18.44892 1.000 171.97433 ? 64  ALA B HB1  1 
ATOM 1588 H HB2  . ALA B 2 63  ? -16.69495 15.09323  17.52606 1.000 171.97433 ? 64  ALA B HB2  1 
ATOM 1589 H HB3  . ALA B 2 63  ? -16.48991 13.60639  18.04643 1.000 171.97433 ? 64  ALA B HB3  1 
ATOM 1590 N N    . LYS B 2 64  ? -19.06618 13.28637  19.39943 1.000 170.63920 ? 65  LYS B N    1 
ATOM 1591 C CA   . LYS B 2 64  ? -20.44265 12.81595  19.22956 1.000 186.21833 ? 65  LYS B CA   1 
ATOM 1592 C C    . LYS B 2 64  ? -21.18947 13.56907  18.12346 1.000 194.02533 ? 65  LYS B C    1 
ATOM 1593 O O    . LYS B 2 64  ? -22.19425 14.24216  18.35341 1.000 193.61624 ? 65  LYS B O    1 
ATOM 1594 C CB   . LYS B 2 64  ? -21.20294 12.85642  20.55846 1.000 188.29954 ? 65  LYS B CB   1 
ATOM 1595 C CG   . LYS B 2 64  ? -21.26264 14.20298  21.27885 1.000 174.54768 ? 65  LYS B CG   1 
ATOM 1596 C CD   . LYS B 2 64  ? -20.74331 14.08369  22.71870 1.000 163.92902 ? 65  LYS B CD   1 
ATOM 1597 C CE   . LYS B 2 64  ? -21.52665 13.05719  23.55110 1.000 222.31506 ? 65  LYS B CE   1 
ATOM 1598 N NZ   . LYS B 2 64  ? -20.85503 12.72063  24.84082 1.000 187.05348 ? 65  LYS B NZ   1 
ATOM 1599 H H    . LYS B 2 64  ? -18.52434 12.65143  19.60646 1.000 207.31264 ? 65  LYS B H    1 
ATOM 1600 H HA   . LYS B 2 64  ? -20.39658 11.89281  18.93530 1.000 226.00760 ? 65  LYS B HA   1 
ATOM 1601 H HB2  . LYS B 2 64  ? -22.11877 12.58593  20.38817 1.000 228.50505 ? 65  LYS B HB2  1 
ATOM 1602 H HB3  . LYS B 2 64  ? -20.77925 12.22951  21.16539 1.000 228.50505 ? 65  LYS B HB3  1 
ATOM 1603 H HG2  . LYS B 2 64  ? -20.71137 14.84638  20.80658 1.000 212.00282 ? 65  LYS B HG2  1 
ATOM 1604 H HG3  . LYS B 2 64  ? -22.18149 14.51234  21.30915 1.000 212.00282 ? 65  LYS B HG3  1 
ATOM 1605 H HD2  . LYS B 2 64  ? -19.81422 13.80576  22.69785 1.000 199.26043 ? 65  LYS B HD2  1 
ATOM 1606 H HD3  . LYS B 2 64  ? -20.82190 14.94607  23.15578 1.000 199.26043 ? 65  LYS B HD3  1 
ATOM 1607 H HE2  . LYS B 2 64  ? -22.40287 13.41941  23.75586 1.000 269.32368 ? 65  LYS B HE2  1 
ATOM 1608 H HE3  . LYS B 2 64  ? -21.61752 12.23858  23.03874 1.000 269.32368 ? 65  LYS B HE3  1 
ATOM 1609 H HZ1  . LYS B 2 64  ? -19.99009 12.56372  24.70172 1.000 227.00977 ? 65  LYS B HZ1  1 
ATOM 1610 H HZ2  . LYS B 2 64  ? -21.22663 11.99466  25.19716 1.000 227.00977 ? 65  LYS B HZ2  1 
ATOM 1611 H HZ3  . LYS B 2 64  ? -20.93745 13.39761  25.41267 1.000 227.00977 ? 65  LYS B HZ3  1 
ATOM 1612 N N    . GLY B 2 65  ? -20.65964 13.45700  16.90294 1.000 162.79416 ? 66  GLY B N    1 
ATOM 1613 C CA   . GLY B 2 65  ? -21.33532 13.96674  15.72385 1.000 167.82979 ? 66  GLY B CA   1 
ATOM 1614 C C    . GLY B 2 65  ? -21.28014 15.46320  15.50772 1.000 199.29200 ? 66  GLY B C    1 
ATOM 1615 O O    . GLY B 2 65  ? -21.86077 15.94768  14.52752 1.000 222.78109 ? 66  GLY B O    1 
ATOM 1616 H H    . GLY B 2 65  ? -19.90218 13.08504  16.73708 1.000 197.89860 ? 66  GLY B H    1 
ATOM 1617 H HA2  . GLY B 2 65  ? -20.94146 13.54756  14.94278 1.000 203.94135 ? 66  GLY B HA2  1 
ATOM 1618 H HA3  . GLY B 2 65  ? -22.27110 13.71722  15.77807 1.000 203.94135 ? 66  GLY B HA3  1 
ATOM 1619 N N    . ARG B 2 66  ? -20.61748 16.21269  16.38345 1.000 196.29897 ? 67  ARG B N    1 
ATOM 1620 C CA   . ARG B 2 66  ? -20.55498 17.66395  16.26375 1.000 157.78222 ? 67  ARG B CA   1 
ATOM 1621 C C    . ARG B 2 66  ? -19.39367 18.14270  15.40426 1.000 156.79108 ? 67  ARG B C    1 
ATOM 1622 O O    . ARG B 2 66  ? -19.47483 19.22779  14.81534 1.000 160.75701 ? 67  ARG B O    1 
ATOM 1623 C CB   . ARG B 2 66  ? -20.44412 18.27731  17.65995 1.000 141.20824 ? 67  ARG B CB   1 
ATOM 1624 C CG   . ARG B 2 66  ? -21.60980 17.91129  18.56081 1.000 182.78553 ? 67  ARG B CG   1 
ATOM 1625 C CD   . ARG B 2 66  ? -21.48545 18.55292  19.92456 1.000 168.45020 ? 67  ARG B CD   1 
ATOM 1626 N NE   . ARG B 2 66  ? -20.27353 18.10467  20.60210 1.000 143.81496 ? 67  ARG B NE   1 
ATOM 1627 C CZ   . ARG B 2 66  ? -19.50435 18.86964  21.36504 1.000 162.04739 ? 67  ARG B CZ   1 
ATOM 1628 N NH1  . ARG B 2 66  ? -19.77850 20.14703  21.56582 1.000 201.99628 ? 67  ARG B NH1  1 
ATOM 1629 N NH2  . ARG B 2 66  ? -18.42260 18.34220  21.92945 1.000 201.12686 ? 67  ARG B NH2  1 
ATOM 1630 H H    . ARG B 2 66  ? -20.19160 15.90105  17.06250 1.000 238.10436 ? 67  ARG B H    1 
ATOM 1631 H HA   . ARG B 2 66  ? -21.37041 17.98444  15.84752 1.000 191.88426 ? 67  ARG B HA   1 
ATOM 1632 H HB2  . ARG B 2 66  ? -19.62953 17.95947  18.07987 1.000 171.99549 ? 67  ARG B HB2  1 
ATOM 1633 H HB3  . ARG B 2 66  ? -20.42018 19.24359  17.57853 1.000 171.99549 ? 67  ARG B HB3  1 
ATOM 1634 H HG2  . ARG B 2 66  ? -22.43642 18.21665  18.15540 1.000 221.88824 ? 67  ARG B HG2  1 
ATOM 1635 H HG3  . ARG B 2 66  ? -21.63388 16.94879  18.67873 1.000 221.88824 ? 67  ARG B HG3  1 
ATOM 1636 H HD2  . ARG B 2 66  ? -21.44396 19.51699  19.82580 1.000 204.68585 ? 67  ARG B HD2  1 
ATOM 1637 H HD3  . ARG B 2 66  ? -22.25041 18.30774  20.46827 1.000 204.68585 ? 67  ARG B HD3  1 
ATOM 1638 H HE   . ARG B 2 66  ? -20.04061 17.28325  20.49906 1.000 175.12356 ? 67  ARG B HE   1 
ATOM 1639 H HH11 . ARG B 2 66  ? -20.47019 20.50141  21.19761 1.000 244.94114 ? 67  ARG B HH11 1 
ATOM 1640 H HH12 . ARG B 2 66  ? -19.26518 20.62374  22.06467 1.000 244.94114 ? 67  ARG B HH12 1 
ATOM 1641 H HH21 . ARG B 2 66  ? -18.22905 17.51466  21.79786 1.000 243.89783 ? 67  ARG B HH21 1 
ATOM 1642 H HH22 . ARG B 2 66  ? -17.91628 18.82849  22.42619 1.000 243.89783 ? 67  ARG B HH22 1 
ATOM 1643 N N    . PHE B 2 67  ? -18.31989 17.36530  15.31824 1.000 189.94629 ? 68  PHE B N    1 
ATOM 1644 C CA   . PHE B 2 67  ? -17.09223 17.78724  14.66146 1.000 144.38566 ? 68  PHE B CA   1 
ATOM 1645 C C    . PHE B 2 67  ? -16.97180 17.12229  13.29533 1.000 159.64218 ? 68  PHE B C    1 
ATOM 1646 O O    . PHE B 2 67  ? -17.40213 15.98334  13.09445 1.000 223.75831 ? 68  PHE B O    1 
ATOM 1647 C CB   . PHE B 2 67  ? -15.86154 17.46382  15.51864 1.000 142.05305 ? 68  PHE B CB   1 
ATOM 1648 C CG   . PHE B 2 67  ? -15.86089 18.12603  16.87742 1.000 163.22261 ? 68  PHE B CG   1 
ATOM 1649 C CD1  . PHE B 2 67  ? -16.85651 19.02096  17.24443 1.000 165.21494 ? 68  PHE B CD1  1 
ATOM 1650 C CD2  . PHE B 2 67  ? -14.83263 17.88127  17.77144 1.000 150.41048 ? 68  PHE B CD2  1 
ATOM 1651 C CE1  . PHE B 2 67  ? -16.83891 19.63397  18.48177 1.000 155.37784 ? 68  PHE B CE1  1 
ATOM 1652 C CE2  . PHE B 2 67  ? -14.81000 18.49495  19.01086 1.000 147.42099 ? 68  PHE B CE2  1 
ATOM 1653 C CZ   . PHE B 2 67  ? -15.81772 19.36662  19.36803 1.000 149.38383 ? 68  PHE B CZ   1 
ATOM 1654 H H    . PHE B 2 67  ? -18.27882 16.56938  15.64138 1.000 230.48116 ? 68  PHE B H    1 
ATOM 1655 H HA   . PHE B 2 67  ? -17.11296 18.74818  14.53084 1.000 175.80839 ? 68  PHE B HA   1 
ATOM 1656 H HB2  . PHE B 2 67  ? -15.82469 16.50473  15.65889 1.000 173.00927 ? 68  PHE B HB2  1 
ATOM 1657 H HB3  . PHE B 2 67  ? -15.06800 17.76078  15.04639 1.000 173.00927 ? 68  PHE B HB3  1 
ATOM 1658 H HD1  . PHE B 2 67  ? -17.54507 19.21038  16.64868 1.000 200.80353 ? 68  PHE B HD1  1 
ATOM 1659 H HD2  . PHE B 2 67  ? -14.14857 17.29696  17.53577 1.000 183.03818 ? 68  PHE B HD2  1 
ATOM 1660 H HE1  . PHE B 2 67  ? -17.51573 20.22687  18.71692 1.000 188.99901 ? 68  PHE B HE1  1 
ATOM 1661 H HE2  . PHE B 2 67  ? -14.11512 18.31982  19.60362 1.000 179.45079 ? 68  PHE B HE2  1 
ATOM 1662 H HZ   . PHE B 2 67  ? -15.80810 19.77281  20.20458 1.000 181.80620 ? 68  PHE B HZ   1 
ATOM 1663 N N    . THR B 2 68  ? -16.38583 17.85877  12.35276 1.000 141.69103 ? 69  THR B N    1 
ATOM 1664 C CA   . THR B 2 68  ? -16.09109 17.35281  11.01524 1.000 163.06978 ? 69  THR B CA   1 
ATOM 1665 C C    . THR B 2 68  ? -14.67399 17.76160  10.64582 1.000 162.15292 ? 69  THR B C    1 
ATOM 1666 O O    . THR B 2 68  ? -14.38537 18.95301  10.50885 1.000 171.01701 ? 69  THR B O    1 
ATOM 1667 C CB   . THR B 2 68  ? -17.09241 17.88595  9.98446  1.000 175.34582 ? 69  THR B CB   1 
ATOM 1668 O OG1  . THR B 2 68  ? -18.42930 17.66374  10.45119 1.000 132.34599 ? 69  THR B OG1  1 
ATOM 1669 C CG2  . THR B 2 68  ? -16.90020 17.19986  8.63324  1.000 185.39441 ? 69  THR B CG2  1 
ATOM 1670 H H    . THR B 2 68  ? -16.14364 18.67583  12.46827 1.000 172.57484 ? 69  THR B H    1 
ATOM 1671 H HA   . THR B 2 68  ? -16.14336 16.38422  11.01623 1.000 198.22934 ? 69  THR B HA   1 
ATOM 1672 H HB   . THR B 2 68  ? -16.94905 18.83725  9.86048  1.000 212.96059 ? 69  THR B HB   1 
ATOM 1673 H HG1  . THR B 2 68  ? -18.63533 18.24599  11.02052 1.000 161.36080 ? 69  THR B HG1  1 
ATOM 1674 H HG21 . THR B 2 68  ? -17.54385 17.54165  7.99308  1.000 225.01889 ? 69  THR B HG21 1 
ATOM 1675 H HG22 . THR B 2 68  ? -17.02659 16.24264  8.72624  1.000 225.01889 ? 69  THR B HG22 1 
ATOM 1676 H HG23 . THR B 2 68  ? -16.00494 17.36828  8.30002  1.000 225.01889 ? 69  THR B HG23 1 
ATOM 1677 N N    . ILE B 2 69  ? -13.80156 16.78100  10.47374 1.000 152.10218 ? 70  ILE B N    1 
ATOM 1678 C CA   . ILE B 2 69  ? -12.45338 17.01301  9.96981  1.000 162.62211 ? 70  ILE B CA   1 
ATOM 1679 C C    . ILE B 2 69  ? -12.46574 16.93609  8.45021  1.000 162.55671 ? 70  ILE B C    1 
ATOM 1680 O O    . ILE B 2 69  ? -13.15169 16.09487  7.85637  1.000 166.55042 ? 70  ILE B O    1 
ATOM 1681 C CB   . ILE B 2 69  ? -11.46716 15.99700  10.57943 1.000 155.23435 ? 70  ILE B CB   1 
ATOM 1682 C CG1  . ILE B 2 69  ? -10.02315 16.37458  10.23950 1.000 195.85843 ? 70  ILE B CG1  1 
ATOM 1683 C CG2  . ILE B 2 69  ? -11.77925 14.58233  10.09501 1.000 185.19455 ? 70  ILE B CG2  1 
ATOM 1684 C CD1  . ILE B 2 69  ? -8.99576  15.55817  10.99400 1.000 171.23342 ? 70  ILE B CD1  1 
ATOM 1685 H H    . ILE B 2 69  ? -13.96827 15.95482  10.64468 1.000 185.06821 ? 70  ILE B H    1 
ATOM 1686 H HA   . ILE B 2 69  ? -12.16706 17.90517  10.22072 1.000 197.69213 ? 70  ILE B HA   1 
ATOM 1687 H HB   . ILE B 2 69  ? -11.57097 16.02086  11.54356 1.000 188.82682 ? 70  ILE B HB   1 
ATOM 1688 H HG12 . ILE B 2 69  ? -9.87731  16.23352  9.29096  1.000 237.57571 ? 70  ILE B HG12 1 
ATOM 1689 H HG13 . ILE B 2 69  ? -9.88281  17.30835  10.46148 1.000 237.57571 ? 70  ILE B HG13 1 
ATOM 1690 H HG21 . ILE B 2 69  ? -12.69881 14.36808  10.31729 1.000 224.77907 ? 70  ILE B HG21 1 
ATOM 1691 H HG22 . ILE B 2 69  ? -11.17913 13.95887  10.53326 1.000 224.77907 ? 70  ILE B HG22 1 
ATOM 1692 H HG23 . ILE B 2 69  ? -11.65337 14.54262  9.13403  1.000 224.77907 ? 70  ILE B HG23 1 
ATOM 1693 H HD11 . ILE B 2 69  ? -9.00759  14.64800  10.65882 1.000 208.02571 ? 70  ILE B HD11 1 
ATOM 1694 H HD12 . ILE B 2 69  ? -8.11888  15.94968  10.85718 1.000 208.02571 ? 70  ILE B HD12 1 
ATOM 1695 H HD13 . ILE B 2 69  ? -9.21777  15.56586  11.93821 1.000 208.02571 ? 70  ILE B HD13 1 
ATOM 1696 N N    . SER B 2 70  ? -11.69799 17.82180  7.81850  1.000 183.53502 ? 71  SER B N    1 
ATOM 1697 C CA   . SER B 2 70  ? -11.57093 17.85153  6.36564  1.000 167.55841 ? 71  SER B CA   1 
ATOM 1698 C C    . SER B 2 70  ? -10.21405 18.45025  6.02350  1.000 191.79593 ? 71  SER B C    1 
ATOM 1699 O O    . SER B 2 70  ? -9.43862  18.81126  6.90757  1.000 202.18752 ? 71  SER B O    1 
ATOM 1700 C CB   . SER B 2 70  ? -12.70860 18.65029  5.71899  1.000 179.36289 ? 71  SER B CB   1 
ATOM 1701 O OG   . SER B 2 70  ? -12.61090 20.02938  6.03562  1.000 205.99316 ? 71  SER B OG   1 
ATOM 1702 H H    . SER B 2 70  ? -11.23322 18.42566  8.21718  1.000 222.78762 ? 71  SER B H    1 
ATOM 1703 H HA   . SER B 2 70  ? -11.61111 16.94335  6.02726  1.000 203.61570 ? 71  SER B HA   1 
ATOM 1704 H HB2  . SER B 2 70  ? -12.65922 18.54452  4.75604  1.000 217.78107 ? 71  SER B HB2  1 
ATOM 1705 H HB3  . SER B 2 70  ? -13.55639 18.31171  6.04689  1.000 217.78107 ? 71  SER B HB3  1 
ATOM 1706 H HG   . SER B 2 70  ? -13.02205 20.18989  6.75032  1.000 249.73740 ? 71  SER B HG   1 
ATOM 1707 N N    . ARG B 2 71  ? -9.89260  18.49099  4.73395  1.000 190.01634 ? 72  ARG B N    1 
ATOM 1708 C CA   . ARG B 2 71  ? -8.64267  19.10333  4.30733  1.000 207.19975 ? 72  ARG B CA   1 
ATOM 1709 C C    . ARG B 2 71  ? -8.81688  19.74393  2.93775  1.000 214.68409 ? 72  ARG B C    1 
ATOM 1710 O O    . ARG B 2 71  ? -9.71836  19.39283  2.17208  1.000 204.93261 ? 72  ARG B O    1 
ATOM 1711 C CB   . ARG B 2 71  ? -7.50955  18.07450  4.30647  1.000 175.71206 ? 72  ARG B CB   1 
ATOM 1712 C CG   . ARG B 2 71  ? -7.65927  17.01411  3.25033  1.000 193.00727 ? 72  ARG B CG   1 
ATOM 1713 C CD   . ARG B 2 71  ? -6.62336  15.93498  3.42017  1.000 194.83812 ? 72  ARG B CD   1 
ATOM 1714 N NE   . ARG B 2 71  ? -6.67818  14.99804  2.30806  1.000 208.62738 ? 72  ARG B NE   1 
ATOM 1715 C CZ   . ARG B 2 71  ? -6.70194  13.67936  2.43270  1.000 179.02727 ? 72  ARG B CZ   1 
ATOM 1716 N NH1  . ARG B 2 71  ? -6.45938  13.08751  3.59062  1.000 164.10303 ? 72  ARG B NH1  1 
ATOM 1717 N NH2  . ARG B 2 71  ? -6.95024  12.93422  1.36116  1.000 191.31023 ? 72  ARG B NH2  1 
ATOM 1718 H H    . ARG B 2 71  ? -10.37599 18.17482  4.09680  1.000 230.56521 ? 72  ARG B H    1 
ATOM 1719 H HA   . ARG B 2 71  ? -8.40685  19.82008  4.91689  1.000 251.18531 ? 72  ARG B HA   1 
ATOM 1720 H HB2  . ARG B 2 71  ? -6.67026  18.53438  4.14836  1.000 213.40008 ? 72  ARG B HB2  1 
ATOM 1721 H HB3  . ARG B 2 71  ? -7.48823  17.63262  5.16971  1.000 213.40008 ? 72  ARG B HB3  1 
ATOM 1722 H HG2  . ARG B 2 71  ? -8.53824  16.60985  3.32029  1.000 234.15433 ? 72  ARG B HG2  1 
ATOM 1723 H HG3  . ARG B 2 71  ? -7.54639  17.41295  2.37335  1.000 234.15433 ? 72  ARG B HG3  1 
ATOM 1724 H HD2  . ARG B 2 71  ? -5.73953  16.33386  3.44550  1.000 236.35134 ? 72  ARG B HD2  1 
ATOM 1725 H HD3  . ARG B 2 71  ? -6.79180  15.44920  4.24269  1.000 236.35134 ? 72  ARG B HD3  1 
ATOM 1726 H HE   . ARG B 2 71  ? -6.69648  15.32393  1.51241  1.000 252.89845 ? 72  ARG B HE   1 
ATOM 1727 H HH11 . ARG B 2 71  ? -6.28074  13.56058  4.28624  1.000 199.46924 ? 72  ARG B HH11 1 
ATOM 1728 H HH12 . ARG B 2 71  ? -6.48033  12.22967  3.64778  1.000 199.46924 ? 72  ARG B HH12 1 
ATOM 1729 H HH21 . ARG B 2 71  ? -7.09267  13.30906  0.60037  1.000 232.11788 ? 72  ARG B HH21 1 
ATOM 1730 H HH22 . ARG B 2 71  ? -6.96853  12.07705  1.42833  1.000 232.11788 ? 72  ARG B HH22 1 
ATOM 1731 N N    . ASP B 2 72  ? -7.93017  20.69304  2.64079  1.000 212.41788 ? 73  ASP B N    1 
ATOM 1732 C CA   . ASP B 2 72  ? -7.74233  21.22742  1.29698  1.000 198.47837 ? 73  ASP B CA   1 
ATOM 1733 C C    . ASP B 2 72  ? -6.33921  20.83484  0.84150  1.000 197.62215 ? 73  ASP B C    1 
ATOM 1734 O O    . ASP B 2 72  ? -5.33959  21.25011  1.44890  1.000 182.00595 ? 73  ASP B O    1 
ATOM 1735 C CB   . ASP B 2 72  ? -7.94230  22.74312  1.28366  1.000 211.58045 ? 73  ASP B CB   1 
ATOM 1736 C CG   . ASP B 2 72  ? -7.78329  23.35012  -0.10070 1.000 259.47938 ? 73  ASP B CG   1 
ATOM 1737 O OD1  . ASP B 2 72  ? -6.94080  22.87122  -0.88530 1.000 260.88514 ? 73  ASP B OD1  1 
ATOM 1738 O OD2  . ASP B 2 72  ? -8.51062  24.31899  -0.40532 1.000 214.77596 ? 73  ASP B OD2  1 
ATOM 1739 H H    . ASP B 2 72  ? -7.40940  21.05372  3.22243  1.000 257.44706 ? 73  ASP B H    1 
ATOM 1740 H HA   . ASP B 2 72  ? -8.38662  20.83872  0.68484  1.000 240.71965 ? 73  ASP B HA   1 
ATOM 1741 H HB2  . ASP B 2 72  ? -8.83725  22.94585  1.59809  1.000 256.44214 ? 73  ASP B HB2  1 
ATOM 1742 H HB3  . ASP B 2 72  ? -7.28482  23.15304  1.86726  1.000 256.44214 ? 73  ASP B HB3  1 
ATOM 1743 N N    . ASN B 2 73  ? -6.28070  19.99217  -0.19784 1.000 218.93328 ? 74  ASN B N    1 
ATOM 1744 C CA   . ASN B 2 73  ? -5.00996  19.46799  -0.69177 1.000 240.77860 ? 74  ASN B CA   1 
ATOM 1745 C C    . ASN B 2 73  ? -4.16093  20.54368  -1.36090 1.000 235.53684 ? 74  ASN B C    1 
ATOM 1746 O O    . ASN B 2 73  ? -2.92829  20.50002  -1.27449 1.000 227.16930 ? 74  ASN B O    1 
ATOM 1747 C CB   . ASN B 2 73  ? -5.26591  18.32922  -1.68127 1.000 258.55018 ? 74  ASN B CB   1 
ATOM 1748 C CG   . ASN B 2 73  ? -6.01253  17.16729  -1.05753 1.000 220.80755 ? 74  ASN B CG   1 
ATOM 1749 O OD1  . ASN B 2 73  ? -5.91800  16.92630  0.14539  1.000 220.48034 ? 74  ASN B OD1  1 
ATOM 1750 N ND2  . ASN B 2 73  ? -6.75026  16.42941  -1.88051 1.000 161.19876 ? 74  ASN B ND2  1 
ATOM 1751 H H    . ASN B 2 73  ? -6.96603  19.70942  -0.63371 1.000 265.26554 ? 74  ASN B H    1 
ATOM 1752 H HA   . ASN B 2 73  ? -4.51207  19.12125  0.06505  1.000 291.47992 ? 74  ASN B HA   1 
ATOM 1753 H HB2  . ASN B 2 73  ? -5.79746  18.66557  -2.41967 1.000 312.80582 ? 74  ASN B HB2  1 
ATOM 1754 H HB3  . ASN B 2 73  ? -4.41513  17.99789  -2.00882 1.000 312.80582 ? 74  ASN B HB3  1 
ATOM 1755 H HD21 . ASN B 2 73  ? -6.78446  16.62296  -2.71775 1.000 195.98412 ? 74  ASN B HD21 1 
ATOM 1756 H HD22 . ASN B 2 73  ? -7.19348  15.75833  -1.57586 1.000 195.98412 ? 74  ASN B HD22 1 
ATOM 1757 N N    . THR B 2 74  ? -4.79475  21.50994  -2.03152 1.000 226.79078 ? 75  THR B N    1 
ATOM 1758 C CA   . THR B 2 74  ? -4.03910  22.56374  -2.70383 1.000 223.73010 ? 75  THR B CA   1 
ATOM 1759 C C    . THR B 2 74  ? -3.39161  23.50554  -1.69859 1.000 216.45351 ? 75  THR B C    1 
ATOM 1760 O O    . THR B 2 74  ? -2.23450  23.90633  -1.86888 1.000 186.42365 ? 75  THR B O    1 
ATOM 1761 C CB   . THR B 2 74  ? -4.95388  23.34162  -3.65110 1.000 215.18669 ? 75  THR B CB   1 
ATOM 1762 O OG1  . THR B 2 74  ? -5.51775  22.44833  -4.62053 1.000 165.27022 ? 75  THR B OG1  1 
ATOM 1763 C CG2  . THR B 2 74  ? -4.18115  24.43995  -4.36792 1.000 178.91899 ? 75  THR B CG2  1 
ATOM 1764 H H    . THR B 2 74  ? -5.64858  21.57593  -2.11042 1.000 274.69454 ? 75  THR B H    1 
ATOM 1765 H HA   . THR B 2 74  ? -3.33526  22.15459  -3.23118 1.000 271.02172 ? 75  THR B HA   1 
ATOM 1766 H HB   . THR B 2 74  ? -5.66625  23.75543  -3.13906 1.000 260.76963 ? 75  THR B HB   1 
ATOM 1767 H HG1  . THR B 2 74  ? -6.08727  21.95042  -4.25538 1.000 200.86987 ? 75  THR B HG1  1 
ATOM 1768 H HG21 . THR B 2 74  ? -4.74253  24.85535  -5.04113 1.000 217.24839 ? 75  THR B HG21 1 
ATOM 1769 H HG22 . THR B 2 74  ? -3.39661  24.06643  -4.79905 1.000 217.24839 ? 75  THR B HG22 1 
ATOM 1770 H HG23 . THR B 2 74  ? -3.89910  25.11618  -3.73227 1.000 217.24839 ? 75  THR B HG23 1 
ATOM 1771 N N    . LYS B 2 75  ? -4.11839  23.86673  -0.64769 1.000 209.58132 ? 76  LYS B N    1 
ATOM 1772 C CA   . LYS B 2 75  ? -3.58574  24.71721  0.40496  1.000 207.08138 ? 76  LYS B CA   1 
ATOM 1773 C C    . LYS B 2 75  ? -2.77942  23.92507  1.42229  1.000 207.11438 ? 76  LYS B C    1 
ATOM 1774 O O    . LYS B 2 75  ? -2.19377  24.52394  2.32974  1.000 185.59541 ? 76  LYS B O    1 
ATOM 1775 C CB   . LYS B 2 75  ? -4.72959  25.47349  1.08472  1.000 212.09783 ? 76  LYS B CB   1 
ATOM 1776 C CG   . LYS B 2 75  ? -5.49873  26.34855  0.10669  1.000 201.90410 ? 76  LYS B CG   1 
ATOM 1777 C CD   . LYS B 2 75  ? -6.45894  27.30357  0.79025  1.000 202.81160 ? 76  LYS B CD   1 
ATOM 1778 C CE   . LYS B 2 75  ? -7.27975  28.06345  -0.24213 1.000 208.91366 ? 76  LYS B CE   1 
ATOM 1779 N NZ   . LYS B 2 75  ? -8.66818  28.34070  0.21362  1.000 256.06899 ? 76  LYS B NZ   1 
ATOM 1780 H H    . LYS B 2 75  ? -4.93477  23.62792  -0.52077 1.000 254.04319 ? 76  LYS B H    1 
ATOM 1781 H HA   . LYS B 2 75  ? -2.99506  25.38471  0.02229  1.000 251.04325 ? 76  LYS B HA   1 
ATOM 1782 H HB2  . LYS B 2 75  ? -5.34852  24.83413  1.47078  1.000 257.06300 ? 76  LYS B HB2  1 
ATOM 1783 H HB3  . LYS B 2 75  ? -4.36519  26.04370  1.77969  1.000 257.06300 ? 76  LYS B HB3  1 
ATOM 1784 H HG2  . LYS B 2 75  ? -4.86786  26.87698  -0.40680 1.000 244.83052 ? 76  LYS B HG2  1 
ATOM 1785 H HG3  . LYS B 2 75  ? -6.01509  25.78016  -0.48594 1.000 244.83052 ? 76  LYS B HG3  1 
ATOM 1786 H HD2  . LYS B 2 75  ? -7.06461  26.80363  1.35957  1.000 245.91952 ? 76  LYS B HD2  1 
ATOM 1787 H HD3  . LYS B 2 75  ? -5.95866  27.94411  1.31972  1.000 245.91952 ? 76  LYS B HD3  1 
ATOM 1788 H HE2  . LYS B 2 75  ? -6.84932  28.91337  -0.42453 1.000 253.24200 ? 76  LYS B HE2  1 
ATOM 1789 H HE3  . LYS B 2 75  ? -7.33119  27.53645  -1.05487 1.000 253.24200 ? 76  LYS B HE3  1 
ATOM 1790 H HZ1  . LYS B 2 75  ? -9.11299  27.57676  0.31670  1.000 309.82839 ? 76  LYS B HZ1  1 
ATOM 1791 H HZ2  . LYS B 2 75  ? -9.09135  28.84250  -0.38739 1.000 309.82839 ? 76  LYS B HZ2  1 
ATOM 1792 H HZ3  . LYS B 2 75  ? -8.65263  28.77308  0.99138  1.000 309.82839 ? 76  LYS B HZ3  1 
ATOM 1793 N N    . ASN B 2 76  ? -2.70470  22.60461  1.26127  1.000 222.19075 ? 77  ASN B N    1 
ATOM 1794 C CA   . ASN B 2 76  ? -2.05517  21.71936  2.22136  1.000 216.11353 ? 77  ASN B CA   1 
ATOM 1795 C C    . ASN B 2 76  ? -2.47105  22.05314  3.65214  1.000 200.36104 ? 77  ASN B C    1 
ATOM 1796 O O    . ASN B 2 76  ? -1.63937  22.25185  4.54074  1.000 173.91404 ? 77  ASN B O    1 
ATOM 1797 C CB   . ASN B 2 76  ? -0.53659  21.79709  2.06312  1.000 182.70122 ? 77  ASN B CB   1 
ATOM 1798 C CG   . ASN B 2 76  ? 0.15924   20.52436  2.48434  1.000 176.34094 ? 77  ASN B CG   1 
ATOM 1799 O OD1  . ASN B 2 76  ? -0.16565  19.43991  2.00704  1.000 194.21101 ? 77  ASN B OD1  1 
ATOM 1800 N ND2  . ASN B 2 76  ? 1.12553   20.65037  3.38312  1.000 183.04521 ? 77  ASN B ND2  1 
ATOM 1801 H H    . ASN B 2 76  ? -3.03253  22.18770  0.58428  1.000 269.17450 ? 77  ASN B H    1 
ATOM 1802 H HA   . ASN B 2 76  ? -2.34041  20.80905  2.04563  1.000 261.88184 ? 77  ASN B HA   1 
ATOM 1803 H HB2  . ASN B 2 76  ? -0.32367  21.96130  1.13113  1.000 221.78707 ? 77  ASN B HB2  1 
ATOM 1804 H HB3  . ASN B 2 76  ? -0.19785  22.52061  2.61327  1.000 221.78707 ? 77  ASN B HB3  1 
ATOM 1805 H HD21 . ASN B 2 76  ? 1.32547   21.42709  3.69350  1.000 222.19985 ? 77  ASN B HD21 1 
ATOM 1806 H HD22 . ASN B 2 76  ? 1.55246   19.95540  3.65580  1.000 222.19985 ? 77  ASN B HD22 1 
ATOM 1807 N N    . THR B 2 77  ? -3.78460  22.11936  3.87153  1.000 178.55437 ? 78  THR B N    1 
ATOM 1808 C CA   . THR B 2 77  ? -4.33743  22.61261  5.12790  1.000 158.16809 ? 78  THR B CA   1 
ATOM 1809 C C    . THR B 2 77  ? -5.37919  21.63116  5.64050  1.000 167.07458 ? 78  THR B C    1 
ATOM 1810 O O    . THR B 2 77  ? -6.16232  21.08646  4.86026  1.000 181.27839 ? 78  THR B O    1 
ATOM 1811 C CB   . THR B 2 77  ? -4.95410  24.01145  4.97666  1.000 189.28039 ? 78  THR B CB   1 
ATOM 1812 O OG1  . THR B 2 77  ? -3.92729  24.95196  4.64352  1.000 179.18768 ? 78  THR B OG1  1 
ATOM 1813 C CG2  . THR B 2 77  ? -5.62329  24.45148  6.27757  1.000 185.72371 ? 78  THR B CG2  1 
ATOM 1814 H H    . THR B 2 77  ? -4.38062  21.88084  3.29929  1.000 216.81085 ? 78  THR B H    1 
ATOM 1815 H HA   . THR B 2 77  ? -3.62790  22.67702  5.78618  1.000 192.34731 ? 78  THR B HA   1 
ATOM 1816 H HB   . THR B 2 77  ? -5.62476  23.99139  4.27615  1.000 229.68207 ? 78  THR B HB   1 
ATOM 1817 H HG1  . THR B 2 77  ? -3.48324  24.67221  3.98765  1.000 217.57082 ? 78  THR B HG1  1 
ATOM 1818 H HG21 . THR B 2 77  ? -5.96841  25.35323  6.18462  1.000 225.41406 ? 78  THR B HG21 1 
ATOM 1819 H HG22 . THR B 2 77  ? -6.35692  23.85416  6.49182  1.000 225.41406 ? 78  THR B HG22 1 
ATOM 1820 H HG23 . THR B 2 77  ? -4.98052  24.43372  7.00381  1.000 225.41406 ? 78  THR B HG23 1 
ATOM 1821 N N    . VAL B 2 78  ? -5.37823  21.39240  6.95020  1.000 180.06725 ? 79  VAL B N    1 
ATOM 1822 C CA   . VAL B 2 78  ? -6.37440  20.53349  7.58315  1.000 177.17429 ? 79  VAL B CA   1 
ATOM 1823 C C    . VAL B 2 78  ? -7.33310  21.41278  8.37397  1.000 183.45332 ? 79  VAL B C    1 
ATOM 1824 O O    . VAL B 2 78  ? -6.91624  22.37362  9.02291  1.000 183.93065 ? 79  VAL B O    1 
ATOM 1825 C CB   . VAL B 2 78  ? -5.71414  19.48656  8.50572  1.000 165.15720 ? 79  VAL B CB   1 
ATOM 1826 C CG1  . VAL B 2 78  ? -6.72139  18.43654  8.94080  1.000 152.90954 ? 79  VAL B CG1  1 
ATOM 1827 C CG2  . VAL B 2 78  ? -4.50873  18.83916  7.83244  1.000 131.42995 ? 79  VAL B CG2  1 
ATOM 1828 H H    . VAL B 2 78  ? -4.80301  21.72128  7.49843  1.000 218.62630 ? 79  VAL B H    1 
ATOM 1829 H HA   . VAL B 2 78  ? -6.87381  20.06436  6.89656  1.000 215.15475 ? 79  VAL B HA   1 
ATOM 1830 H HB   . VAL B 2 78  ? -5.39536  19.94166  9.30081  1.000 200.73424 ? 79  VAL B HB   1 
ATOM 1831 H HG11 . VAL B 2 78  ? -7.47057  18.87698  9.37167  1.000 186.03705 ? 79  VAL B HG11 1 
ATOM 1832 H HG12 . VAL B 2 78  ? -7.02824  17.95041  8.15951  1.000 186.03705 ? 79  VAL B HG12 1 
ATOM 1833 H HG13 . VAL B 2 78  ? -6.29371  17.82719  9.56265  1.000 186.03705 ? 79  VAL B HG13 1 
ATOM 1834 H HG21 . VAL B 2 78  ? -3.84620  19.52269  7.64606  1.000 160.26155 ? 79  VAL B HG21 1 
ATOM 1835 H HG22 . VAL B 2 78  ? -4.79543  18.42202  7.00497  1.000 160.26155 ? 79  VAL B HG22 1 
ATOM 1836 H HG23 . VAL B 2 78  ? -4.13567  18.17054  8.42799  1.000 160.26155 ? 79  VAL B HG23 1 
ATOM 1837 N N    . TYR B 2 79  ? -8.61930  21.08698  8.31803  1.000 166.98540 ? 80  TYR B N    1 
ATOM 1838 C CA   . TYR B 2 79  ? -9.65804  21.85006  8.98714  1.000 164.30621 ? 80  TYR B CA   1 
ATOM 1839 C C    . TYR B 2 79  ? -10.39110 20.96685  9.98584  1.000 148.83190 ? 80  TYR B C    1 
ATOM 1840 O O    . TYR B 2 79  ? -10.58339 19.76560  9.75604  1.000 138.14227 ? 80  TYR B O    1 
ATOM 1841 C CB   . TYR B 2 79  ? -10.67233 22.41892  7.98702  1.000 173.05683 ? 80  TYR B CB   1 
ATOM 1842 C CG   . TYR B 2 79  ? -10.08383 23.26364  6.88126  1.000 163.03606 ? 80  TYR B CG   1 
ATOM 1843 C CD1  . TYR B 2 79  ? -9.71650  24.58221  7.11209  1.000 175.67690 ? 80  TYR B CD1  1 
ATOM 1844 C CD2  . TYR B 2 79  ? -9.89329  22.74391  5.60750  1.000 157.81200 ? 80  TYR B CD2  1 
ATOM 1845 C CE1  . TYR B 2 79  ? -9.19444  25.36590  6.10234  1.000 189.70700 ? 80  TYR B CE1  1 
ATOM 1846 C CE2  . TYR B 2 79  ? -9.35411  23.51522  4.59508  1.000 185.97516 ? 80  TYR B CE2  1 
ATOM 1847 C CZ   . TYR B 2 79  ? -9.01131  24.82681  4.84671  1.000 208.63555 ? 80  TYR B CZ   1 
ATOM 1848 O OH   . TYR B 2 79  ? -8.47257  25.59523  3.84178  1.000 187.86250 ? 80  TYR B OH   1 
ATOM 1849 H H    . TYR B 2 79  ? -8.92077  20.40770  7.88526  1.000 202.92808 ? 80  TYR B H    1 
ATOM 1850 H HA   . TYR B 2 79  ? -9.24765  22.58786  9.46476  1.000 199.71305 ? 80  TYR B HA   1 
ATOM 1851 H HB2  . TYR B 2 79  ? -11.13811 21.67798  7.56874  1.000 210.21379 ? 80  TYR B HB2  1 
ATOM 1852 H HB3  . TYR B 2 79  ? -11.30176 22.97491  8.47240  1.000 210.21379 ? 80  TYR B HB3  1 
ATOM 1853 H HD1  . TYR B 2 79  ? -9.82395  24.94418  7.96199  1.000 213.35788 ? 80  TYR B HD1  1 
ATOM 1854 H HD2  . TYR B 2 79  ? -10.13243 21.86232  5.43283  1.000 191.92001 ? 80  TYR B HD2  1 
ATOM 1855 H HE1  . TYR B 2 79  ? -8.96762  26.25242  6.26825  1.000 230.19400 ? 80  TYR B HE1  1 
ATOM 1856 H HE2  . TYR B 2 79  ? -9.22334  23.15164  3.74915  1.000 225.71580 ? 80  TYR B HE2  1 
ATOM 1857 H HH   . TYR B 2 79  ? -8.14697  26.30013  4.16225  1.000 227.98060 ? 80  TYR B HH   1 
ATOM 1858 N N    . LEU B 2 80  ? -10.86365 21.59834  11.06017 1.000 177.24076 ? 81  LEU B N    1 
ATOM 1859 C CA   . LEU B 2 80  ? -11.80891 20.98702  11.99234 1.000 152.64252 ? 81  LEU B CA   1 
ATOM 1860 C C    . LEU B 2 80  ? -12.98786 21.92985  12.18764 1.000 189.22963 ? 81  LEU B C    1 
ATOM 1861 O O    . LEU B 2 80  ? -12.84749 22.97765  12.82396 1.000 168.09220 ? 81  LEU B O    1 
ATOM 1862 C CB   . LEU B 2 80  ? -11.13914 20.68770  13.33537 1.000 162.38293 ? 81  LEU B CB   1 
ATOM 1863 C CG   . LEU B 2 80  ? -11.94651 19.85993  14.34204 1.000 156.99938 ? 81  LEU B CG   1 
ATOM 1864 C CD1  . LEU B 2 80  ? -12.11692 18.43144  13.86063 1.000 157.65471 ? 81  LEU B CD1  1 
ATOM 1865 C CD2  . LEU B 2 80  ? -11.29687 19.89307  15.72109 1.000 147.02392 ? 81  LEU B CD2  1 
ATOM 1866 H H    . LEU B 2 80  ? -10.64538 22.40197  11.27495 1.000 215.23451 ? 81  LEU B H    1 
ATOM 1867 H HA   . LEU B 2 80  ? -12.13854 20.15891  11.60961 1.000 185.71663 ? 81  LEU B HA   1 
ATOM 1868 H HB2  . LEU B 2 80  ? -10.31994 20.19919  13.15879 1.000 197.40512 ? 81  LEU B HB2  1 
ATOM 1869 H HB3  . LEU B 2 80  ? -10.93508 21.53406  13.76307 1.000 197.40512 ? 81  LEU B HB3  1 
ATOM 1870 H HG   . LEU B 2 80  ? -12.83046 20.25133  14.42170 1.000 190.94486 ? 81  LEU B HG   1 
ATOM 1871 H HD11 . LEU B 2 80  ? -12.68507 18.42880  13.07443 1.000 191.73125 ? 81  LEU B HD11 1 
ATOM 1872 H HD12 . LEU B 2 80  ? -12.52646 17.90705  14.56645 1.000 191.73125 ? 81  LEU B HD12 1 
ATOM 1873 H HD13 . LEU B 2 80  ? -11.24566 18.06636  13.64034 1.000 191.73125 ? 81  LEU B HD13 1 
ATOM 1874 H HD21 . LEU B 2 80  ? -11.85087 19.39609  16.34318 1.000 178.97430 ? 81  LEU B HD21 1 
ATOM 1875 H HD22 . LEU B 2 80  ? -11.21903 20.81532  16.01143 1.000 178.97430 ? 81  LEU B HD22 1 
ATOM 1876 H HD23 . LEU B 2 80  ? -10.41707 19.48840  15.66553 1.000 178.97430 ? 81  LEU B HD23 1 
ATOM 1877 N N    . GLN B 2 81  ? -14.14096 21.56846  11.63587 1.000 196.87446 ? 82  GLN B N    1 
ATOM 1878 C CA   . GLN B 2 81  ? -15.37189 22.29863  11.89095 1.000 180.39850 ? 82  GLN B CA   1 
ATOM 1879 C C    . GLN B 2 81  ? -15.96346 21.79184  13.20164 1.000 163.54109 ? 82  GLN B C    1 
ATOM 1880 O O    . GLN B 2 81  ? -16.08464 20.57759  13.40028 1.000 146.22413 ? 82  GLN B O    1 
ATOM 1881 C CB   . GLN B 2 81  ? -16.34280 22.09221  10.72855 1.000 153.18924 ? 82  GLN B CB   1 
ATOM 1882 C CG   . GLN B 2 81  ? -17.67797 22.79505  10.85684 1.000 162.95899 ? 82  GLN B CG   1 
ATOM 1883 C CD   . GLN B 2 81  ? -17.54740 24.29490  10.69010 1.000 192.36789 ? 82  GLN B CD   1 
ATOM 1884 O OE1  . GLN B 2 81  ? -16.82355 24.77091  9.81513  1.000 159.26665 ? 82  GLN B OE1  1 
ATOM 1885 N NE2  . GLN B 2 81  ? -18.25282 25.04847  11.52163 1.000 194.21414 ? 82  GLN B NE2  1 
ATOM 1886 H H    . GLN B 2 81  ? -14.23578 20.89792  11.10578 1.000 238.79496 ? 82  GLN B H    1 
ATOM 1887 H HA   . GLN B 2 81  ? -15.20926 23.25168  11.96941 1.000 219.02380 ? 82  GLN B HA   1 
ATOM 1888 H HB2  . GLN B 2 81  ? -15.92168 22.41958  9.91837  1.000 186.37269 ? 82  GLN B HB2  1 
ATOM 1889 H HB3  . GLN B 2 81  ? -16.52375 21.14265  10.64802 1.000 186.37269 ? 82  GLN B HB3  1 
ATOM 1890 H HG2  . GLN B 2 81  ? -18.27951 22.46495  10.17121 1.000 198.09640 ? 82  GLN B HG2  1 
ATOM 1891 H HG3  . GLN B 2 81  ? -18.04821 22.61876  11.73590 1.000 198.09640 ? 82  GLN B HG3  1 
ATOM 1892 H HE21 . GLN B 2 81  ? -18.75210 24.68023  12.11721 1.000 235.60257 ? 82  GLN B HE21 1 
ATOM 1893 H HE22 . GLN B 2 81  ? -18.21123 25.90563  11.46555 1.000 235.60257 ? 82  GLN B HE22 1 
ATOM 1894 N N    . MET B 2 82  ? -16.33474 22.71352  14.09229 1.000 148.30763 ? 83  MET B N    1 
ATOM 1895 C CA   . MET B 2 82  ? -16.86396 22.37580  15.41226 1.000 151.52688 ? 83  MET B CA   1 
ATOM 1896 C C    . MET B 2 82  ? -18.18773 23.09707  15.62891 1.000 181.23697 ? 83  MET B C    1 
ATOM 1897 O O    . MET B 2 82  ? -18.21357 24.32742  15.74344 1.000 167.39569 ? 83  MET B O    1 
ATOM 1898 C CB   . MET B 2 82  ? -15.86473 22.76531  16.50134 1.000 139.89484 ? 83  MET B CB   1 
ATOM 1899 C CG   . MET B 2 82  ? -14.59570 21.93243  16.51154 1.000 161.53335 ? 83  MET B CG   1 
ATOM 1900 S SD   . MET B 2 82  ? -13.67598 22.07055  18.05737 1.000 195.56332 ? 83  MET B SD   1 
ATOM 1901 C CE   . MET B 2 82  ? -12.97619 23.71411  17.88737 1.000 155.42955 ? 83  MET B CE   1 
ATOM 1902 H H    . MET B 2 82  ? -16.28775 23.56039  13.95013 1.000 180.51475 ? 83  MET B H    1 
ATOM 1903 H HA   . MET B 2 82  ? -17.02476 21.41984  15.44657 1.000 184.37786 ? 83  MET B HA   1 
ATOM 1904 H HB2  . MET B 2 82  ? -15.60749 23.69114  16.36883 1.000 170.41942 ? 83  MET B HB2  1 
ATOM 1905 H HB3  . MET B 2 82  ? -16.29214 22.66018  17.36573 1.000 170.41942 ? 83  MET B HB3  1 
ATOM 1906 H HG2  . MET B 2 82  ? -14.82972 20.99962  16.38501 1.000 196.38562 ? 83  MET B HG2  1 
ATOM 1907 H HG3  . MET B 2 82  ? -14.01746 22.22997  15.79181 1.000 196.38562 ? 83  MET B HG3  1 
ATOM 1908 H HE1  . MET B 2 82  ? -12.65773 23.82928  16.97841 1.000 189.06106 ? 83  MET B HE1  1 
ATOM 1909 H HE2  . MET B 2 82  ? -12.23912 23.80954  18.51069 1.000 189.06106 ? 83  MET B HE2  1 
ATOM 1910 H HE3  . MET B 2 82  ? -13.66225 24.37126  18.08327 1.000 189.06106 ? 83  MET B HE3  1 
ATOM 1911 N N    . ASP B 2 83  ? -19.27905 22.33739  15.68020 1.000 207.88385 ? 84  ASP B N    1 
ATOM 1912 C CA   . ASP B 2 83  ? -20.61980 22.87054  15.87143 1.000 177.23630 ? 84  ASP B CA   1 
ATOM 1913 C C    . ASP B 2 83  ? -21.12015 22.57408  17.28202 1.000 160.97925 ? 84  ASP B C    1 
ATOM 1914 O O    . ASP B 2 83  ? -20.63809 21.66293  17.95997 1.000 169.36326 ? 84  ASP B O    1 
ATOM 1915 C CB   . ASP B 2 83  ? -21.59159 22.29057  14.83936 1.000 169.55565 ? 84  ASP B CB   1 
ATOM 1916 C CG   . ASP B 2 83  ? -21.21413 22.65506  13.41729 1.000 173.14041 ? 84  ASP B CG   1 
ATOM 1917 O OD1  . ASP B 2 83  ? -20.32835 23.51638  13.24113 1.000 152.75983 ? 84  ASP B OD1  1 
ATOM 1918 O OD2  . ASP B 2 83  ? -21.80536 22.08452  12.47838 1.000 209.37112 ? 84  ASP B OD2  1 
ATOM 1919 H H    . ASP B 2 83  ? -19.26485 21.48091  15.60379 1.000 252.00622 ? 84  ASP B H    1 
ATOM 1920 H HA   . ASP B 2 83  ? -20.59615 23.83385  15.76019 1.000 215.22916 ? 84  ASP B HA   1 
ATOM 1921 H HB2  . ASP B 2 83  ? -21.59134 21.32331  14.91225 1.000 206.01239 ? 84  ASP B HB2  1 
ATOM 1922 H HB3  . ASP B 2 83  ? -22.48128 22.63608  15.01251 1.000 206.01239 ? 84  ASP B HB3  1 
ATOM 1923 N N    . ASN B 2 84  ? -22.11024 23.35696  17.71125 1.000 176.86277 ? 85  ASN B N    1 
ATOM 1924 C CA   . ASN B 2 84  ? -22.76748 23.18063  19.00964 1.000 186.20999 ? 85  ASN B CA   1 
ATOM 1925 C C    . ASN B 2 84  ? -21.74610 23.06067  20.13998 1.000 168.79427 ? 85  ASN B C    1 
ATOM 1926 O O    . ASN B 2 84  ? -21.79200 22.14534  20.96328 1.000 153.52520 ? 85  ASN B O    1 
ATOM 1927 C CB   . ASN B 2 84  ? -23.69541 21.96124  18.97761 1.000 158.37530 ? 85  ASN B CB   1 
ATOM 1928 C CG   . ASN B 2 84  ? -24.58669 21.86524  20.20369 1.000 198.67887 ? 85  ASN B CG   1 
ATOM 1929 O OD1  . ASN B 2 84  ? -24.91136 22.87284  20.83285 1.000 187.87048 ? 85  ASN B OD1  1 
ATOM 1930 N ND2  . ASN B 2 84  ? -24.99472 20.64673  20.54257 1.000 183.34857 ? 85  ASN B ND2  1 
ATOM 1931 H H    . ASN B 2 84  ? -22.42833 24.01472  17.25764 1.000 214.78093 ? 85  ASN B H    1 
ATOM 1932 H HA   . ASN B 2 84  ? -23.30214 23.96947  19.19070 1.000 225.99759 ? 85  ASN B HA   1 
ATOM 1933 H HB2  . ASN B 2 84  ? -24.26676 22.01981  18.19593 1.000 192.59596 ? 85  ASN B HB2  1 
ATOM 1934 H HB3  . ASN B 2 84  ? -23.15672 21.15569  18.93520 1.000 192.59596 ? 85  ASN B HB3  1 
ATOM 1935 H HD21 . ASN B 2 84  ? -24.75228 19.96664  20.07534 1.000 222.56389 ? 85  ASN B HD21 1 
ATOM 1936 H HD22 . ASN B 2 84  ? -25.50120 20.53829  21.22909 1.000 222.56389 ? 85  ASN B HD22 1 
ATOM 1937 N N    . LEU B 2 85  ? -20.82071 24.01460  20.18095 1.000 159.68975 ? 86  LEU B N    1 
ATOM 1938 C CA   . LEU B 2 85  ? -19.74904 23.98157  21.16617 1.000 143.91017 ? 86  LEU B CA   1 
ATOM 1939 C C    . LEU B 2 85  ? -20.30511 24.10867  22.58136 1.000 158.42236 ? 86  LEU B C    1 
ATOM 1940 O O    . LEU B 2 85  ? -21.36722 24.68930  22.80971 1.000 188.95627 ? 86  LEU B O    1 
ATOM 1941 C CB   . LEU B 2 85  ? -18.72919 25.08405  20.88113 1.000 165.46267 ? 86  LEU B CB   1 
ATOM 1942 C CG   . LEU B 2 85  ? -17.78682 24.74012  19.72342 1.000 191.94961 ? 86  LEU B CG   1 
ATOM 1943 C CD1  . LEU B 2 85  ? -17.08291 25.97542  19.19246 1.000 175.26748 ? 86  LEU B CD1  1 
ATOM 1944 C CD2  . LEU B 2 85  ? -16.77048 23.69190  20.16231 1.000 165.60684 ? 86  LEU B CD2  1 
ATOM 1945 H H    . LEU B 2 85  ? -20.79164 24.69042  19.64990 1.000 194.17330 ? 86  LEU B H    1 
ATOM 1946 H HA   . LEU B 2 85  ? -19.28664 23.13068  21.11069 1.000 175.23780 ? 86  LEU B HA   1 
ATOM 1947 H HB2  . LEU B 2 85  ? -19.20284 25.89866  20.65098 1.000 201.10080 ? 86  LEU B HB2  1 
ATOM 1948 H HB3  . LEU B 2 85  ? -18.19021 25.22665  21.67490 1.000 201.10080 ? 86  LEU B HB3  1 
ATOM 1949 H HG   . LEU B 2 85  ? -18.31437 24.37406  18.99638 1.000 232.88513 ? 86  LEU B HG   1 
ATOM 1950 H HD11 . LEU B 2 85  ? -16.57673 25.73471  18.40079 1.000 212.86658 ? 86  LEU B HD11 1 
ATOM 1951 H HD12 . LEU B 2 85  ? -17.74726 26.64597  18.96909 1.000 212.86658 ? 86  LEU B HD12 1 
ATOM 1952 H HD13 . LEU B 2 85  ? -16.48532 26.31672  19.87606 1.000 212.86658 ? 86  LEU B HD13 1 
ATOM 1953 H HD21 . LEU B 2 85  ? -16.12506 23.56024  19.45027 1.000 201.27382 ? 86  LEU B HD21 1 
ATOM 1954 H HD22 . LEU B 2 85  ? -17.23420 22.86005  20.34640 1.000 201.27382 ? 86  LEU B HD22 1 
ATOM 1955 H HD23 . LEU B 2 85  ? -16.32061 24.00402  20.96299 1.000 201.27382 ? 86  LEU B HD23 1 
ATOM 1956 N N    . LYS B 2 86  ? -19.57833 23.53612  23.53308 1.000 146.98179 ? 87  LYS B N    1 
ATOM 1957 C CA   . LYS B 2 86  ? -19.94124 23.50068  24.93887 1.000 149.44776 ? 87  LYS B CA   1 
ATOM 1958 C C    . LYS B 2 86  ? -18.76982 24.01967  25.75939 1.000 141.87837 ? 87  LYS B C    1 
ATOM 1959 O O    . LYS B 2 86  ? -17.62111 23.94533  25.31437 1.000 149.68492 ? 87  LYS B O    1 
ATOM 1960 C CB   . LYS B 2 86  ? -20.30297 22.07277  25.37460 1.000 192.93132 ? 87  LYS B CB   1 
ATOM 1961 C CG   . LYS B 2 86  ? -21.50852 21.49996  24.63870 1.000 164.79103 ? 87  LYS B CG   1 
ATOM 1962 C CD   . LYS B 2 86  ? -21.72843 20.03496  24.97697 1.000 204.96192 ? 87  LYS B CD   1 
ATOM 1963 C CE   . LYS B 2 86  ? -22.43358 19.30618  23.84170 1.000 208.46839 ? 87  LYS B CE   1 
ATOM 1964 N NZ   . LYS B 2 86  ? -22.73217 17.88702  24.17723 1.000 217.19630 ? 87  LYS B NZ   1 
ATOM 1965 H H    . LYS B 2 86  ? -18.83047 23.14071  23.37833 1.000 178.92375 ? 87  LYS B H    1 
ATOM 1966 H HA   . LYS B 2 86  ? -20.71232 24.06381  25.10985 1.000 181.88291 ? 87  LYS B HA   1 
ATOM 1967 H HB2  . LYS B 2 86  ? -19.54568 21.49173  25.20195 1.000 234.06318 ? 87  LYS B HB2  1 
ATOM 1968 H HB3  . LYS B 2 86  ? -20.50812 22.07753  26.32265 1.000 234.06318 ? 87  LYS B HB3  1 
ATOM 1969 H HG2  . LYS B 2 86  ? -22.30381 21.99355  24.89325 1.000 200.29484 ? 87  LYS B HG2  1 
ATOM 1970 H HG3  . LYS B 2 86  ? -21.36472 21.57296  23.68220 1.000 200.29484 ? 87  LYS B HG3  1 
ATOM 1971 H HD2  . LYS B 2 86  ? -20.87124 19.60723  25.12924 1.000 248.49990 ? 87  LYS B HD2  1 
ATOM 1972 H HD3  . LYS B 2 86  ? -22.27905 19.96711  25.77265 1.000 248.49990 ? 87  LYS B HD3  1 
ATOM 1973 H HE2  . LYS B 2 86  ? -23.27275 19.75332  23.64999 1.000 252.70767 ? 87  LYS B HE2  1 
ATOM 1974 H HE3  . LYS B 2 86  ? -21.86499 19.31666  23.05589 1.000 252.70767 ? 87  LYS B HE3  1 
ATOM 1975 H HZ1  . LYS B 2 86  ? -22.01431 17.50128  24.53495 1.000 263.18116 ? 87  LYS B HZ1  1 
ATOM 1976 H HZ2  . LYS B 2 86  ? -22.96264 17.44230  23.44156 1.000 263.18116 ? 87  LYS B HZ2  1 
ATOM 1977 H HZ3  . LYS B 2 86  ? -23.40276 17.84686  24.76101 1.000 263.18116 ? 87  LYS B HZ3  1 
ATOM 1978 N N    . PRO B 2 87  ? -19.02915 24.58529  26.94159 1.000 165.04937 ? 88  PRO B N    1 
ATOM 1979 C CA   . PRO B 2 87  ? -17.91189 24.96517  27.82696 1.000 177.63306 ? 88  PRO B CA   1 
ATOM 1980 C C    . PRO B 2 87  ? -16.85210 23.88608  28.01233 1.000 214.15654 ? 88  PRO B C    1 
ATOM 1981 O O    . PRO B 2 87  ? -15.66421 24.21251  28.12553 1.000 257.18818 ? 88  PRO B O    1 
ATOM 1982 C CB   . PRO B 2 87  ? -18.62944 25.29043  29.14471 1.000 208.39686 ? 88  PRO B CB   1 
ATOM 1983 C CG   . PRO B 2 87  ? -19.96675 25.78718  28.71483 1.000 238.14242 ? 88  PRO B CG   1 
ATOM 1984 C CD   . PRO B 2 87  ? -20.33568 24.93771  27.52772 1.000 214.13303 ? 88  PRO B CD   1 
ATOM 1985 H HA   . PRO B 2 87  ? -17.48120 25.75991  27.47509 1.000 215.70527 ? 88  PRO B HA   1 
ATOM 1986 H HB2  . PRO B 2 87  ? -18.71034 24.49046  29.68731 1.000 252.62183 ? 88  PRO B HB2  1 
ATOM 1987 H HB3  . PRO B 2 87  ? -18.14148 25.97324  29.63108 1.000 252.62183 ? 88  PRO B HB3  1 
ATOM 1988 H HG2  . PRO B 2 87  ? -20.60789 25.67484  29.43401 1.000 288.31650 ? 88  PRO B HG2  1 
ATOM 1989 H HG3  . PRO B 2 87  ? -19.90751 26.72294  28.46634 1.000 288.31650 ? 88  PRO B HG3  1 
ATOM 1990 H HD2  . PRO B 2 87  ? -20.81385 24.14178  27.80834 1.000 259.50524 ? 88  PRO B HD2  1 
ATOM 1991 H HD3  . PRO B 2 87  ? -20.87237 25.44181  26.89625 1.000 259.50524 ? 88  PRO B HD3  1 
ATOM 1992 N N    . GLU B 2 88  ? -17.24479 22.61107  28.05598 1.000 221.70675 ? 89  GLU B N    1 
ATOM 1993 C CA   . GLU B 2 88  ? -16.28067 21.52775  28.23929 1.000 236.18069 ? 89  GLU B CA   1 
ATOM 1994 C C    . GLU B 2 88  ? -15.30766 21.37396  27.07305 1.000 180.87569 ? 89  GLU B C    1 
ATOM 1995 O O    . GLU B 2 88  ? -14.27733 20.71230  27.23384 1.000 206.40141 ? 89  GLU B O    1 
ATOM 1996 C CB   . GLU B 2 88  ? -17.00573 20.19615  28.48448 1.000 254.55154 ? 89  GLU B CB   1 
ATOM 1997 C CG   . GLU B 2 88  ? -18.22981 20.26685  29.41104 1.000 255.31317 ? 89  GLU B CG   1 
ATOM 1998 C CD   . GLU B 2 88  ? -19.51950 20.63939  28.70011 1.000 253.55441 ? 89  GLU B CD   1 
ATOM 1999 O OE1  . GLU B 2 88  ? -20.06799 19.78534  27.97388 1.000 270.63948 ? 89  GLU B OE1  1 
ATOM 2000 O OE2  . GLU B 2 88  ? -19.99095 21.78195  28.87788 1.000 208.74439 ? 89  GLU B OE2  1 
ATOM 2001 H H    . GLU B 2 88  ? -18.06038 22.34845  27.98220 1.000 268.59371 ? 89  GLU B H    1 
ATOM 2002 H HA   . GLU B 2 88  ? -15.75614 21.73770  29.02776 1.000 285.96243 ? 89  GLU B HA   1 
ATOM 2003 H HB2  . GLU B 2 88  ? -17.31069 19.85354  27.62977 1.000 308.00745 ? 89  GLU B HB2  1 
ATOM 2004 H HB3  . GLU B 2 88  ? -16.37654 19.57603  28.88506 1.000 308.00745 ? 89  GLU B HB3  1 
ATOM 2005 H HG2  . GLU B 2 88  ? -18.35999 19.39803  29.82227 1.000 308.92141 ? 89  GLU B HG2  1 
ATOM 2006 H HG3  . GLU B 2 88  ? -18.06553 20.93585  30.09393 1.000 308.92141 ? 89  GLU B HG3  1 
ATOM 2007 N N    . ASP B 2 89  ? -15.59928 21.95854  25.91339 1.000 168.70905 ? 90  ASP B N    1 
ATOM 2008 C CA   . ASP B 2 89  ? -14.66311 21.98185  24.79255 1.000 188.27012 ? 90  ASP B CA   1 
ATOM 2009 C C    . ASP B 2 89  ? -13.55837 23.02702  24.91858 1.000 210.00067 ? 90  ASP B C    1 
ATOM 2010 O O    . ASP B 2 89  ? -12.68783 23.08031  24.04426 1.000 167.28086 ? 90  ASP B O    1 
ATOM 2011 C CB   . ASP B 2 89  ? -15.40961 22.22368  23.48011 1.000 182.42843 ? 90  ASP B CB   1 
ATOM 2012 C CG   . ASP B 2 89  ? -16.47987 21.18876  23.21699 1.000 179.28302 ? 90  ASP B CG   1 
ATOM 2013 O OD1  . ASP B 2 89  ? -16.19088 19.98144  23.27429 1.000 151.99408 ? 90  ASP B OD1  1 
ATOM 2014 O OD2  . ASP B 2 89  ? -17.61933 21.58696  22.92377 1.000 201.42197 ? 90  ASP B OD2  1 
ATOM 2015 H H    . ASP B 2 89  ? -16.34452 22.35473  25.74832 1.000 204.99646 ? 90  ASP B H    1 
ATOM 2016 H HA   . ASP B 2 89  ? -14.24118 21.10905  24.75958 1.000 228.46974 ? 90  ASP B HA   1 
ATOM 2017 H HB2  . ASP B 2 89  ? -15.83615 23.09418  23.51480 1.000 221.45972 ? 90  ASP B HB2  1 
ATOM 2018 H HB3  . ASP B 2 89  ? -14.77629 22.19358  22.74602 1.000 221.45972 ? 90  ASP B HB3  1 
ATOM 2019 N N    . THR B 2 90  ? -13.54962 23.84877  25.96174 1.000 231.31259 ? 91  THR B N    1 
ATOM 2020 C CA   . THR B 2 90  ? -12.46522 24.80987  26.13010 1.000 207.51038 ? 91  THR B CA   1 
ATOM 2021 C C    . THR B 2 90  ? -11.13214 24.08957  26.28993 1.000 179.02994 ? 91  THR B C    1 
ATOM 2022 O O    . THR B 2 90  ? -10.96203 23.26772  27.19603 1.000 193.34828 ? 91  THR B O    1 
ATOM 2023 C CB   . THR B 2 90  ? -12.73426 25.70327  27.33961 1.000 212.91736 ? 91  THR B CB   1 
ATOM 2024 O OG1  . THR B 2 90  ? -13.91374 26.48032  27.10909 1.000 205.46254 ? 91  THR B OG1  1 
ATOM 2025 C CG2  . THR B 2 90  ? -11.55570 26.64306  27.58563 1.000 199.01199 ? 91  THR B CG2  1 
ATOM 2026 H H    . THR B 2 90  ? -14.14998 23.87032  26.57713 1.000 280.12071 ? 91  THR B H    1 
ATOM 2027 H HA   . THR B 2 90  ? -12.41793 25.37163  25.34074 1.000 251.55805 ? 91  THR B HA   1 
ATOM 2028 H HB   . THR B 2 90  ? -12.85692 25.15055  28.12723 1.000 258.04644 ? 91  THR B HB   1 
ATOM 2029 H HG1  . THR B 2 90  ? -14.58885 26.06890  27.39294 1.000 249.10066 ? 91  THR B HG1  1 
ATOM 2030 H HG21 . THR B 2 90  ? -11.79796 27.31395  28.24298 1.000 241.35999 ? 91  THR B HG21 1 
ATOM 2031 H HG22 . THR B 2 90  ? -10.79387 26.14073  27.91455 1.000 241.35999 ? 91  THR B HG22 1 
ATOM 2032 H HG23 . THR B 2 90  ? -11.30726 27.08689  26.75969 1.000 241.35999 ? 91  THR B HG23 1 
ATOM 2033 N N    . ALA B 2 91  ? -10.18614 24.40676  25.40825 1.000 207.19828 ? 92  ALA B N    1 
ATOM 2034 C CA   . ALA B 2 91  ? -8.88344  23.74664  25.39427 1.000 191.14888 ? 92  ALA B CA   1 
ATOM 2035 C C    . ALA B 2 91  ? -8.01640  24.44688  24.35676 1.000 204.35463 ? 92  ALA B C    1 
ATOM 2036 O O    . ALA B 2 91  ? -8.50527  25.24886  23.55756 1.000 246.55664 ? 92  ALA B O    1 
ATOM 2037 C CB   . ALA B 2 91  ? -9.01513  22.25212  25.08489 1.000 185.48935 ? 92  ALA B CB   1 
ATOM 2038 H H    . ALA B 2 91  ? -10.27611 25.00862  24.80058 1.000 251.18354 ? 92  ALA B H    1 
ATOM 2039 H HA   . ALA B 2 91  ? -8.46048  23.84108  26.26207 1.000 231.92426 ? 92  ALA B HA   1 
ATOM 2040 H HB1  . ALA B 2 91  ? -9.39047  21.80154  25.85755 1.000 225.13282 ? 92  ALA B HB1  1 
ATOM 2041 H HB2  . ALA B 2 91  ? -8.13655  21.89208  24.88646 1.000 225.13282 ? 92  ALA B HB2  1 
ATOM 2042 H HB3  . ALA B 2 91  ? -9.59982  22.13843  24.31930 1.000 225.13282 ? 92  ALA B HB3  1 
ATOM 2043 N N    . VAL B 2 92  ? -6.72304  24.13270  24.36325 1.000 166.35117 ? 93  VAL B N    1 
ATOM 2044 C CA   . VAL B 2 92  ? -5.87243  24.42186  23.21334 1.000 160.61128 ? 93  VAL B CA   1 
ATOM 2045 C C    . VAL B 2 92  ? -5.93120  23.25759  22.23511 1.000 165.91378 ? 93  VAL B C    1 
ATOM 2046 O O    . VAL B 2 92  ? -5.72633  22.10189  22.61923 1.000 145.40338 ? 93  VAL B O    1 
ATOM 2047 C CB   . VAL B 2 92  ? -4.42861  24.70279  23.65573 1.000 174.63732 ? 93  VAL B CB   1 
ATOM 2048 C CG1  . VAL B 2 92  ? -3.58216  25.11894  22.46391 1.000 153.59969 ? 93  VAL B CG1  1 
ATOM 2049 C CG2  . VAL B 2 92  ? -4.41166  25.78491  24.72945 1.000 204.58773 ? 93  VAL B CG2  1 
ATOM 2050 H H    . VAL B 2 92  ? -6.31744  23.75306  25.01972 1.000 202.16701 ? 93  VAL B H    1 
ATOM 2051 H HA   . VAL B 2 92  ? -6.21389  25.20838  22.75981 1.000 195.27914 ? 93  VAL B HA   1 
ATOM 2052 H HB   . VAL B 2 92  ? -4.04577  23.89389  24.02992 1.000 212.11038 ? 93  VAL B HB   1 
ATOM 2053 H HG11 . VAL B 2 92  ? -3.99450  25.88561  22.03603 1.000 186.86523 ? 93  VAL B HG11 1 
ATOM 2054 H HG12 . VAL B 2 92  ? -3.53136  24.37892  21.83886 1.000 186.86523 ? 93  VAL B HG12 1 
ATOM 2055 H HG13 . VAL B 2 92  ? -2.69299  25.35168  22.77394 1.000 186.86523 ? 93  VAL B HG13 1 
ATOM 2056 H HG21 . VAL B 2 92  ? -4.92310  25.47860  25.49463 1.000 248.05087 ? 93  VAL B HG21 1 
ATOM 2057 H HG22 . VAL B 2 92  ? -4.80787  26.59363  24.36905 1.000 248.05087 ? 93  VAL B HG22 1 
ATOM 2058 H HG23 . VAL B 2 92  ? -3.49346  25.95499  24.99193 1.000 248.05087 ? 93  VAL B HG23 1 
ATOM 2059 N N    . TYR B 2 93  ? -6.18114  23.56388  20.96515 1.000 175.20213 ? 94  TYR B N    1 
ATOM 2060 C CA   . TYR B 2 93  ? -6.32663  22.56052  19.92017 1.000 127.11431 ? 94  TYR B CA   1 
ATOM 2061 C C    . TYR B 2 93  ? -5.07743  22.52818  19.04957 1.000 139.59226 ? 94  TYR B C    1 
ATOM 2062 O O    . TYR B 2 93  ? -4.53181  23.57329  18.68257 1.000 168.82342 ? 94  TYR B O    1 
ATOM 2063 C CB   . TYR B 2 93  ? -7.56473  22.81675  19.05902 1.000 124.22256 ? 94  TYR B CB   1 
ATOM 2064 C CG   . TYR B 2 93  ? -8.86258  22.45793  19.74607 1.000 184.80013 ? 94  TYR B CG   1 
ATOM 2065 C CD1  . TYR B 2 93  ? -9.35428  23.22842  20.79011 1.000 194.25346 ? 94  TYR B CD1  1 
ATOM 2066 C CD2  . TYR B 2 93  ? -9.59314  21.34176  19.35466 1.000 166.16044 ? 94  TYR B CD2  1 
ATOM 2067 C CE1  . TYR B 2 93  ? -10.54127 22.90533  21.41751 1.000 165.72340 ? 94  TYR B CE1  1 
ATOM 2068 C CE2  . TYR B 2 93  ? -10.78085 21.01073  19.97743 1.000 205.89452 ? 94  TYR B CE2  1 
ATOM 2069 C CZ   . TYR B 2 93  ? -11.24693 21.79184  21.00940 1.000 195.14193 ? 94  TYR B CZ   1 
ATOM 2070 O OH   . TYR B 2 93  ? -12.42461 21.45881  21.63197 1.000 195.67848 ? 94  TYR B OH   1 
ATOM 2071 H H    . TYR B 2 93  ? -6.27291  24.36937  20.67815 1.000 212.78816 ? 94  TYR B H    1 
ATOM 2072 H HA   . TYR B 2 93  ? -6.43429  21.68925  20.33271 1.000 155.08278 ? 94  TYR B HA   1 
ATOM 2073 H HB2  . TYR B 2 93  ? -7.59894  23.75947  18.83318 1.000 151.61267 ? 94  TYR B HB2  1 
ATOM 2074 H HB3  . TYR B 2 93  ? -7.49928  22.28418  18.25094 1.000 151.61267 ? 94  TYR B HB3  1 
ATOM 2075 H HD1  . TYR B 2 93  ? -8.87649  23.97484  21.07202 1.000 235.64975 ? 94  TYR B HD1  1 
ATOM 2076 H HD2  . TYR B 2 93  ? -9.27667  20.80865  18.66145 1.000 201.93814 ? 94  TYR B HD2  1 
ATOM 2077 H HE1  . TYR B 2 93  ? -10.86317 23.43495  22.11089 1.000 201.41368 ? 94  TYR B HE1  1 
ATOM 2078 H HE2  . TYR B 2 93  ? -11.26226 20.26465  19.70084 1.000 249.61903 ? 94  TYR B HE2  1 
ATOM 2079 H HH   . TYR B 2 93  ? -12.62875 22.04809  22.19471 1.000 237.35978 ? 94  TYR B HH   1 
ATOM 2080 N N    . TYR B 2 94  ? -4.62557  21.31910  18.73297 1.000 142.53066 ? 95  TYR B N    1 
ATOM 2081 C CA   . TYR B 2 94  ? -3.37234  21.09028  18.03006 1.000 165.26266 ? 95  TYR B CA   1 
ATOM 2082 C C    . TYR B 2 94  ? -3.63568  20.15767  16.86041 1.000 165.10491 ? 95  TYR B C    1 
ATOM 2083 O O    . TYR B 2 94  ? -4.48962  19.27733  16.94777 1.000 187.27396 ? 95  TYR B O    1 
ATOM 2084 C CB   . TYR B 2 94  ? -2.31308  20.43240  18.92891 1.000 129.75557 ? 95  TYR B CB   1 
ATOM 2085 C CG   . TYR B 2 94  ? -1.91701  21.20379  20.16613 1.000 127.64743 ? 95  TYR B CG   1 
ATOM 2086 C CD1  . TYR B 2 94  ? -2.62876  21.06223  21.34918 1.000 113.76941 ? 95  TYR B CD1  1 
ATOM 2087 C CD2  . TYR B 2 94  ? -0.85026  22.09379  20.14434 1.000 116.04686 ? 95  TYR B CD2  1 
ATOM 2088 C CE1  . TYR B 2 94  ? -2.26749  21.75798  22.48570 1.000 158.36362 ? 95  TYR B CE1  1 
ATOM 2089 C CE2  . TYR B 2 94  ? -0.49539  22.81310  21.27090 1.000 130.23855 ? 95  TYR B CE2  1 
ATOM 2090 C CZ   . TYR B 2 94  ? -1.19977  22.63342  22.44119 1.000 172.07615 ? 95  TYR B CZ   1 
ATOM 2091 O OH   . TYR B 2 94  ? -0.84855  23.34471  23.56457 1.000 139.24353 ? 95  TYR B OH   1 
ATOM 2092 H H    . TYR B 2 94  ? -5.04329  20.59157  18.92221 1.000 173.58240 ? 95  TYR B H    1 
ATOM 2093 H HA   . TYR B 2 94  ? -3.02895  21.94175  17.71705 1.000 200.86079 ? 95  TYR B HA   1 
ATOM 2094 H HB2  . TYR B 2 94  ? -2.65753  19.57522  19.22470 1.000 158.25228 ? 95  TYR B HB2  1 
ATOM 2095 H HB3  . TYR B 2 94  ? -1.50832  20.30298  18.40306 1.000 158.25228 ? 95  TYR B HB3  1 
ATOM 2096 H HD1  . TYR B 2 94  ? -3.36092  20.48945  21.37683 1.000 139.06889 ? 95  TYR B HD1  1 
ATOM 2097 H HD2  . TYR B 2 94  ? -0.36639  22.20778  19.35835 1.000 141.80184 ? 95  TYR B HD2  1 
ATOM 2098 H HE1  . TYR B 2 94  ? -2.74060  21.63786  23.27731 1.000 192.58195 ? 95  TYR B HE1  1 
ATOM 2099 H HE2  . TYR B 2 94  ? 0.21377   23.41391  21.23873 1.000 158.83186 ? 95  TYR B HE2  1 
ATOM 2100 H HH   . TYR B 2 94  ? -1.12219  22.94837  24.25278 1.000 169.63784 ? 95  TYR B HH   1 
ATOM 2101 N N    . CYS B 2 95  ? -2.96265  20.39142  15.74281 1.000 133.66773 ? 96  CYS B N    1 
ATOM 2102 C CA   . CYS B 2 95  ? -2.97037  19.44586  14.63830 1.000 153.44354 ? 96  CYS B CA   1 
ATOM 2103 C C    . CYS B 2 95  ? -1.58931  18.80683  14.55512 1.000 194.89354 ? 96  CYS B C    1 
ATOM 2104 O O    . CYS B 2 95  ? -0.57595  19.45594  14.82841 1.000 221.69508 ? 96  CYS B O    1 
ATOM 2105 C CB   . CYS B 2 95  ? -3.35157  20.13742  13.33089 1.000 149.13866 ? 96  CYS B CB   1 
ATOM 2106 S SG   . CYS B 2 95  ? -3.23449  19.10493  11.84814 1.000 184.22051 ? 96  CYS B SG   1 
ATOM 2107 H H    . CYS B 2 95  ? -2.49089  21.09625  15.60048 1.000 162.94688 ? 96  CYS B H    1 
ATOM 2108 H HA   . CYS B 2 95  ? -3.62454  18.74282  14.77504 1.000 186.67785 ? 96  CYS B HA   1 
ATOM 2109 H HB2  . CYS B 2 95  ? -4.27045  20.44002  13.40153 1.000 181.51199 ? 96  CYS B HB2  1 
ATOM 2110 H HB3  . CYS B 2 95  ? -2.76125  20.89640  13.20290 1.000 181.51199 ? 96  CYS B HB3  1 
ATOM 2111 H HG   . CYS B 2 95  ? -3.53343  19.76228  10.88974 1.000 223.61021 ? 96  CYS B HG   1 
ATOM 2112 N N    . ASN B 2 96  ? -1.54640  17.53176  14.17405 1.000 152.78286 ? 97  ASN B N    1 
ATOM 2113 C CA   . ASN B 2 96  ? -0.26417  16.85779  14.00331 1.000 136.77955 ? 97  ASN B CA   1 
ATOM 2114 C C    . ASN B 2 96  ? -0.40690  15.65914  13.07637 1.000 144.30372 ? 97  ASN B C    1 
ATOM 2115 O O    . ASN B 2 96  ? -1.51091  15.25399  12.70881 1.000 147.84281 ? 97  ASN B O    1 
ATOM 2116 C CB   . ASN B 2 96  ? 0.28969   16.40953  15.35788 1.000 136.79020 ? 97  ASN B CB   1 
ATOM 2117 C CG   . ASN B 2 96  ? 1.78985   16.57484  15.46225 1.000 145.08618 ? 97  ASN B CG   1 
ATOM 2118 O OD1  . ASN B 2 96  ? 2.51319   16.46797  14.47199 1.000 163.88779 ? 97  ASN B OD1  1 
ATOM 2119 N ND2  . ASN B 2 96  ? 2.26780   16.82578  16.67233 1.000 138.34081 ? 97  ASN B ND2  1 
ATOM 2120 H H    . ASN B 2 96  ? -2.23575  17.04407  14.01111 1.000 185.88504 ? 97  ASN B H    1 
ATOM 2121 H HA   . ASN B 2 96  ? 0.34727   17.47902  13.57774 1.000 166.68106 ? 97  ASN B HA   1 
ATOM 2122 H HB2  . ASN B 2 96  ? -0.11982  16.94132  16.05818 1.000 166.69384 ? 97  ASN B HB2  1 
ATOM 2123 H HB3  . ASN B 2 96  ? 0.08175   15.47124  15.48928 1.000 166.69384 ? 97  ASN B HB3  1 
ATOM 2124 H HD21 . ASN B 2 96  ? 1.73201   16.88591  17.34233 1.000 168.55457 ? 97  ASN B HD21 1 
ATOM 2125 H HD22 . ASN B 2 96  ? 3.11381   16.92853  16.78771 1.000 168.55457 ? 97  ASN B HD22 1 
ATOM 2126 N N    . ALA B 2 97  ? 0.74340   15.13793  12.64498 1.000 184.48257 ? 98  ALA B N    1 
ATOM 2127 C CA   . ALA B 2 97  ? 0.76368   13.81195  12.04209 1.000 205.46219 ? 98  ALA B CA   1 
ATOM 2128 C C    . ALA B 2 97  ? 1.27763   12.78718  13.04847 1.000 159.16129 ? 98  ALA B C    1 
ATOM 2129 O O    . ALA B 2 97  ? 2.13576   13.11068  13.87378 1.000 154.56370 ? 98  ALA B O    1 
ATOM 2130 C CB   . ALA B 2 97  ? 1.65075   13.78612  10.79825 1.000 178.14104 ? 98  ALA B CB   1 
ATOM 2131 H H    . ALA B 2 97  ? 1.50930   15.52644  12.69025 1.000 223.92469 ? 98  ALA B H    1 
ATOM 2132 H HA   . ALA B 2 97  ? -0.13377  13.56460  11.76953 1.000 249.10023 ? 98  ALA B HA   1 
ATOM 2133 H HB1  . ALA B 2 97  ? 1.40823   14.52771  10.22195 1.000 216.31485 ? 98  ALA B HB1  1 
ATOM 2134 H HB2  . ALA B 2 97  ? 1.51577   12.94659  10.33149 1.000 216.31485 ? 98  ALA B HB2  1 
ATOM 2135 H HB3  . ALA B 2 97  ? 2.57827   13.86804  11.07009 1.000 216.31485 ? 98  ALA B HB3  1 
ATOM 2136 N N    . PRO B 2 98  ? 0.74187   11.56395  13.05625 1.000 132.11098 ? 99  PRO B N    1 
ATOM 2137 C CA   . PRO B 2 98  ? 1.11099   10.60979  14.11855 1.000 160.04353 ? 99  PRO B CA   1 
ATOM 2138 C C    . PRO B 2 98  ? 2.60339   10.32331  14.23397 1.000 145.99414 ? 99  PRO B C    1 
ATOM 2139 O O    . PRO B 2 98  ? 3.08148   10.05254  15.34340 1.000 156.50130 ? 99  PRO B O    1 
ATOM 2140 C CB   . PRO B 2 98  ? 0.33557   9.33824   13.73470 1.000 181.06307 ? 99  PRO B CB   1 
ATOM 2141 C CG   . PRO B 2 98  ? -0.12305  9.54866   12.32452 1.000 168.58629 ? 99  PRO B CG   1 
ATOM 2142 C CD   . PRO B 2 98  ? -0.30357  11.01973  12.17860 1.000 167.12418 ? 99  PRO B CD   1 
ATOM 2143 H HA   . PRO B 2 98  ? 0.79289   10.95437  14.96765 1.000 194.59784 ? 99  PRO B HA   1 
ATOM 2144 H HB2  . PRO B 2 98  ? 0.92170   8.56767   13.79446 1.000 219.82129 ? 99  PRO B HB2  1 
ATOM 2145 H HB3  . PRO B 2 98  ? -0.42219  9.22562   14.32970 1.000 219.82129 ? 99  PRO B HB3  1 
ATOM 2146 H HG2  . PRO B 2 98  ? 0.55035   9.22123   11.70790 1.000 204.84915 ? 99  PRO B HG2  1 
ATOM 2147 H HG3  . PRO B 2 98  ? -0.96109  9.08247   12.17875 1.000 204.84915 ? 99  PRO B HG3  1 
ATOM 2148 H HD2  . PRO B 2 98  ? -0.16451  11.29714  11.25957 1.000 203.09462 ? 99  PRO B HD2  1 
ATOM 2149 H HD3  . PRO B 2 98  ? -1.18495  11.29276  12.47781 1.000 203.09462 ? 99  PRO B HD3  1 
ATOM 2150 N N    . GLN B 2 99  ? 3.35827   10.36396  13.13104 1.000 148.46167 ? 100 GLN B N    1 
ATOM 2151 C CA   . GLN B 2 99  ? 4.78499   10.05572  13.20176 1.000 156.29204 ? 100 GLN B CA   1 
ATOM 2152 C C    . GLN B 2 99  ? 5.60389   11.16152  13.85154 1.000 166.27539 ? 100 GLN B C    1 
ATOM 2153 O O    . GLN B 2 99  ? 6.80541   10.96699  14.06427 1.000 209.46565 ? 100 GLN B O    1 
ATOM 2154 C CB   . GLN B 2 99  ? 5.35785   9.74626   11.80835 1.000 156.17520 ? 100 GLN B CB   1 
ATOM 2155 C CG   . GLN B 2 99  ? 5.54446   10.92088  10.84034 1.000 142.56118 ? 100 GLN B CG   1 
ATOM 2156 C CD   . GLN B 2 99  ? 4.36610   11.12203  9.91750  1.000 169.61203 ? 100 GLN B CD   1 
ATOM 2157 O OE1  . GLN B 2 99  ? 3.22245   11.02029  10.33599 1.000 142.31127 ? 100 GLN B OE1  1 
ATOM 2158 N NE2  . GLN B 2 99  ? 4.64135   11.38027  8.64501  1.000 193.98925 ? 100 GLN B NE2  1 
ATOM 2159 H H    . GLN B 2 99  ? 3.07122   10.56381  12.34538 1.000 180.69961 ? 100 GLN B H    1 
ATOM 2160 H HA   . GLN B 2 99  ? 4.88144   9.25364   13.73867 1.000 190.09605 ? 100 GLN B HA   1 
ATOM 2161 H HB2  . GLN B 2 99  ? 6.23137   9.34231   11.92954 1.000 189.95585 ? 100 GLN B HB2  1 
ATOM 2162 H HB3  . GLN B 2 99  ? 4.75937   9.11843   11.37410 1.000 189.95585 ? 100 GLN B HB3  1 
ATOM 2163 H HG2  . GLN B 2 99  ? 5.66414   11.73540  11.35331 1.000 173.61902 ? 100 GLN B HG2  1 
ATOM 2164 H HG3  . GLN B 2 99  ? 6.32771   10.75574  10.29247 1.000 173.61902 ? 100 GLN B HG3  1 
ATOM 2165 H HE21 . GLN B 2 99  ? 5.45907   11.42586  8.38262  1.000 235.33270 ? 100 GLN B HE21 1 
ATOM 2166 H HE22 . GLN B 2 99  ? 4.00196   11.50200  8.08290  1.000 235.33270 ? 100 GLN B HE22 1 
ATOM 2167 N N    . PHE B 2 100 ? 4.99780   12.30598  14.16830 1.000 164.87198 ? 101 PHE B N    1 
ATOM 2168 C CA   . PHE B 2 100 ? 5.72240   13.43278  14.73690 1.000 170.74075 ? 101 PHE B CA   1 
ATOM 2169 C C    . PHE B 2 100 ? 5.24269   13.80834  16.13198 1.000 166.69406 ? 101 PHE B C    1 
ATOM 2170 O O    . PHE B 2 100 ? 5.76560   14.76798  16.70759 1.000 164.44045 ? 101 PHE B O    1 
ATOM 2171 C CB   . PHE B 2 100 ? 5.60624   14.65618  13.81321 1.000 147.73093 ? 101 PHE B CB   1 
ATOM 2172 C CG   . PHE B 2 100 ? 6.07080   14.40034  12.40647 1.000 163.83017 ? 101 PHE B CG   1 
ATOM 2173 C CD1  . PHE B 2 100 ? 7.32772   13.87392  12.16331 1.000 222.50507 ? 101 PHE B CD1  1 
ATOM 2174 C CD2  . PHE B 2 100 ? 5.25474   14.69826  11.32603 1.000 157.18754 ? 101 PHE B CD2  1 
ATOM 2175 C CE1  . PHE B 2 100 ? 7.75888   13.63650  10.87216 1.000 246.85814 ? 101 PHE B CE1  1 
ATOM 2176 C CE2  . PHE B 2 100 ? 5.67965   14.45753  10.03128 1.000 161.37036 ? 101 PHE B CE2  1 
ATOM 2177 C CZ   . PHE B 2 100 ? 6.93396   13.92824  9.80524  1.000 224.85836 ? 101 PHE B CZ   1 
ATOM 2178 H H    . PHE B 2 100 ? 4.15720   12.45214  14.06047 1.000 200.39197 ? 101 PHE B H    1 
ATOM 2179 H HA   . PHE B 2 100 ? 6.66070   13.19545  14.80154 1.000 207.43451 ? 101 PHE B HA   1 
ATOM 2180 H HB2  . PHE B 2 100 ? 4.67629   14.92903  13.77270 1.000 179.82272 ? 101 PHE B HB2  1 
ATOM 2181 H HB3  . PHE B 2 100 ? 6.14712   15.37428  14.17745 1.000 179.82272 ? 101 PHE B HB3  1 
ATOM 2182 H HD1  . PHE B 2 100 ? 7.88924   13.67751  12.87816 1.000 269.55168 ? 101 PHE B HD1  1 
ATOM 2183 H HD2  . PHE B 2 100 ? 4.41240   15.06396  11.47305 1.000 191.17065 ? 101 PHE B HD2  1 
ATOM 2184 H HE1  . PHE B 2 100 ? 8.60476   13.28021  10.72233 1.000 298.77537 ? 101 PHE B HE1  1 
ATOM 2185 H HE2  . PHE B 2 100 ? 5.12048   14.65224  9.31412  1.000 196.19004 ? 101 PHE B HE2  1 
ATOM 2186 H HZ   . PHE B 2 100 ? 7.22260   13.76853  8.93571  1.000 272.37563 ? 101 PHE B HZ   1 
ATOM 2187 N N    . THR B 2 101 ? 4.24677   13.10688  16.68181 1.000 177.85917 ? 102 THR B N    1 
ATOM 2188 C CA   . THR B 2 101 ? 3.72418   13.47155  17.99439 1.000 149.82385 ? 102 THR B CA   1 
ATOM 2189 C C    . THR B 2 101 ? 4.76077   13.30630  19.10343 1.000 160.07752 ? 102 THR B C    1 
ATOM 2190 O O    . THR B 2 101 ? 4.67037   13.99392  20.12606 1.000 147.62743 ? 102 THR B O    1 
ATOM 2191 C CB   . THR B 2 101 ? 2.47901   12.63084  18.31592 1.000 154.60834 ? 102 THR B CB   1 
ATOM 2192 O OG1  . THR B 2 101 ? 2.83033   11.24212  18.38549 1.000 186.48725 ? 102 THR B OG1  1 
ATOM 2193 C CG2  . THR B 2 101 ? 1.39333   12.82992  17.25463 1.000 160.22887 ? 102 THR B CG2  1 
ATOM 2194 H H    . THR B 2 101 ? 3.86417   12.42713  16.31965 1.000 215.97661 ? 102 THR B H    1 
ATOM 2195 H HA   . THR B 2 101 ? 3.47042   14.40734  17.96606 1.000 182.33422 ? 102 THR B HA   1 
ATOM 2196 H HB   . THR B 2 101 ? 2.11998   12.91391  19.17142 1.000 188.07561 ? 102 THR B HB   1 
ATOM 2197 H HG1  . THR B 2 101 ? 3.46016   11.07815  17.85443 1.000 226.33030 ? 102 THR B HG1  1 
ATOM 2198 H HG21 . THR B 2 101 ? 0.61855   12.28612  17.46655 1.000 194.82025 ? 102 THR B HG21 1 
ATOM 2199 H HG22 . THR B 2 101 ? 1.12534   13.76169  17.22490 1.000 194.82025 ? 102 THR B HG22 1 
ATOM 2200 H HG23 . THR B 2 101 ? 1.73043   12.57133  16.38263 1.000 194.82025 ? 102 THR B HG23 1 
ATOM 2201 N N    . ASP B 2 102 ? 5.74843   12.42817  18.91997 1.000 203.59671 ? 103 ASP B N    1 
ATOM 2202 C CA   . ASP B 2 102 ? 6.89072   12.30872  19.82412 1.000 234.73565 ? 103 ASP B CA   1 
ATOM 2203 C C    . ASP B 2 102 ? 7.96392   13.37271  19.61109 1.000 202.17542 ? 103 ASP B C    1 
ATOM 2204 O O    . ASP B 2 102 ? 8.95279   13.37883  20.35236 1.000 202.01373 ? 103 ASP B O    1 
ATOM 2205 C CB   . ASP B 2 102 ? 7.53285   10.92320  19.68938 1.000 232.57493 ? 103 ASP B CB   1 
ATOM 2206 C CG   . ASP B 2 102 ? 8.11156   10.67480  18.30736 1.000 247.64440 ? 103 ASP B CG   1 
ATOM 2207 O OD1  . ASP B 2 102 ? 7.64144   11.29722  17.33307 1.000 252.59849 ? 103 ASP B OD1  1 
ATOM 2208 O OD2  . ASP B 2 102 ? 9.05002   9.85854   18.19954 1.000 271.17717 ? 103 ASP B OD2  1 
ATOM 2209 H H    . ASP B 2 102 ? 5.77981   11.87616  18.26125 1.000 246.86165 ? 103 ASP B H    1 
ATOM 2210 H HA   . ASP B 2 102 ? 6.55491   12.40769  20.72874 1.000 284.22838 ? 103 ASP B HA   1 
ATOM 2211 H HB2  . ASP B 2 102 ? 8.25296   10.84461  20.33449 1.000 281.63552 ? 103 ASP B HB2  1 
ATOM 2212 H HB3  . ASP B 2 102 ? 6.86008   10.24531  19.85894 1.000 281.63552 ? 103 ASP B HB3  1 
ATOM 2213 N N    . ARG B 2 103 ? 7.80529   14.26510  18.63692 1.000 173.79270 ? 104 ARG B N    1 
ATOM 2214 C CA   . ARG B 2 103 ? 8.91410   15.05375  18.11024 1.000 188.99305 ? 104 ARG B CA   1 
ATOM 2215 C C    . ARG B 2 103 ? 8.66977   16.55182  18.18960 1.000 189.53177 ? 104 ARG B C    1 
ATOM 2216 O O    . ARG B 2 103 ? 9.53435   17.29163  18.67361 1.000 205.49246 ? 104 ARG B O    1 
ATOM 2217 C CB   . ARG B 2 103 ? 9.18937   14.65182  16.64873 1.000 208.09073 ? 104 ARG B CB   1 
ATOM 2218 C CG   . ARG B 2 103 ? 10.34134  15.41297  15.99106 1.000 265.47530 ? 104 ARG B CG   1 
ATOM 2219 C CD   . ARG B 2 103 ? 10.73490  14.81014  14.64108 1.000 261.98550 ? 104 ARG B CD   1 
ATOM 2220 N NE   . ARG B 2 103 ? 10.15720  15.54029  13.51767 1.000 283.39185 ? 104 ARG B NE   1 
ATOM 2221 C CZ   . ARG B 2 103 ? 10.60112  15.47800  12.26849 1.000 279.57193 ? 104 ARG B CZ   1 
ATOM 2222 N NH1  . ARG B 2 103 ? 11.58140  14.65919  11.92024 1.000 291.14725 ? 104 ARG B NH1  1 
ATOM 2223 N NH2  . ARG B 2 103 ? 10.03442  16.24417  11.33988 1.000 252.63399 ? 104 ARG B NH2  1 
ATOM 2224 H H    . ARG B 2 103 ? 7.05163   14.43414  18.25874 1.000 211.09684 ? 104 ARG B H    1 
ATOM 2225 H HA   . ARG B 2 103 ? 9.70393   14.85957  18.63879 1.000 229.33726 ? 104 ARG B HA   1 
ATOM 2226 H HB2  . ARG B 2 103 ? 9.40945   13.70745  16.62376 1.000 252.25448 ? 104 ARG B HB2  1 
ATOM 2227 H HB3  . ARG B 2 103 ? 8.38995   14.82011  16.12575 1.000 252.25448 ? 104 ARG B HB3  1 
ATOM 2228 H HG2  . ARG B 2 103 ? 10.07256  16.33332  15.84407 1.000 321.11597 ? 104 ARG B HG2  1 
ATOM 2229 H HG3  . ARG B 2 103 ? 11.11680  15.38272  16.57299 1.000 321.11597 ? 104 ARG B HG3  1 
ATOM 2230 H HD2  . ARG B 2 103 ? 11.70048  14.83413  14.55167 1.000 316.92821 ? 104 ARG B HD2  1 
ATOM 2231 H HD3  . ARG B 2 103 ? 10.42046  13.89350  14.59854 1.000 316.92821 ? 104 ARG B HD3  1 
ATOM 2232 H HE   . ARG B 2 103 ? 9.48080   16.04716  13.67629 1.000 342.61582 ? 104 ARG B HE   1 
ATOM 2233 H HH11 . ARG B 2 103 ? 11.94679  14.15067  12.50973 1.000 351.92230 ? 104 ARG B HH11 1 
ATOM 2234 H HH12 . ARG B 2 103 ? 11.85281  14.63580  11.10452 1.000 351.92230 ? 104 ARG B HH12 1 
ATOM 2235 H HH21 . ARG B 2 103 ? 9.38892   16.77117  11.55248 1.000 305.70639 ? 104 ARG B HH21 1 
ATOM 2236 H HH22 . ARG B 2 103 ? 10.31363  16.21236  10.52709 1.000 305.70639 ? 104 ARG B HH22 1 
ATOM 2237 N N    . TYR B 2 104 ? 7.51314   17.02223  17.73388 1.000 194.47826 ? 105 TYR B N    1 
ATOM 2238 C CA   . TYR B 2 104 ? 7.23440   18.44654  17.62501 1.000 176.33166 ? 105 TYR B CA   1 
ATOM 2239 C C    . TYR B 2 104 ? 5.74539   18.70064  17.77424 1.000 182.24568 ? 105 TYR B C    1 
ATOM 2240 O O    . TYR B 2 104 ? 4.92393   17.93351  17.26929 1.000 220.37178 ? 105 TYR B O    1 
ATOM 2241 C CB   . TYR B 2 104 ? 7.70775   19.00425  16.28018 1.000 173.14674 ? 105 TYR B CB   1 
ATOM 2242 C CG   . TYR B 2 104 ? 7.26620   20.42808  16.03077 1.000 156.90775 ? 105 TYR B CG   1 
ATOM 2243 C CD1  . TYR B 2 104 ? 7.79285   21.48985  16.75426 1.000 150.16052 ? 105 TYR B CD1  1 
ATOM 2244 C CD2  . TYR B 2 104 ? 6.30632   20.70460  15.06897 1.000 135.46625 ? 105 TYR B CD2  1 
ATOM 2245 C CE1  . TYR B 2 104 ? 7.38187   22.78901  16.51287 1.000 158.56242 ? 105 TYR B CE1  1 
ATOM 2246 C CE2  . TYR B 2 104 ? 5.88229   21.99111  14.83058 1.000 131.97564 ? 105 TYR B CE2  1 
ATOM 2247 C CZ   . TYR B 2 104 ? 6.42377   23.03105  15.55441 1.000 143.70777 ? 105 TYR B CZ   1 
ATOM 2248 O OH   . TYR B 2 104 ? 6.00468   24.31778  15.31106 1.000 181.33822 ? 105 TYR B OH   1 
ATOM 2249 H H    . TYR B 2 104 ? 6.86072   16.52466  17.47627 1.000 235.91952 ? 105 TYR B H    1 
ATOM 2250 H HA   . TYR B 2 104 ? 7.69344   18.90663  18.34507 1.000 214.14359 ? 105 TYR B HA   1 
ATOM 2251 H HB2  . TYR B 2 104 ? 8.67728   18.98516  16.25713 1.000 210.32169 ? 105 TYR B HB2  1 
ATOM 2252 H HB3  . TYR B 2 104 ? 7.34803   18.45227  15.56827 1.000 210.32169 ? 105 TYR B HB3  1 
ATOM 2253 H HD1  . TYR B 2 104 ? 8.43098   21.32549  17.41052 1.000 182.73823 ? 105 TYR B HD1  1 
ATOM 2254 H HD2  . TYR B 2 104 ? 5.94186   20.00594  14.57507 1.000 165.10511 ? 105 TYR B HD2  1 
ATOM 2255 H HE1  . TYR B 2 104 ? 7.75042   23.49382  16.99486 1.000 192.82051 ? 105 TYR B HE1  1 
ATOM 2256 H HE2  . TYR B 2 104 ? 5.23414   22.15807  14.18487 1.000 160.91638 ? 105 TYR B HE2  1 
ATOM 2257 H HH   . TYR B 2 104 ? 5.81923   24.41043  14.49705 1.000 220.15147 ? 105 TYR B HH   1 
ATOM 2258 N N    . TRP B 2 105 ? 5.41083   19.78024  18.47563 1.000 150.72669 ? 106 TRP B N    1 
ATOM 2259 C CA   . TRP B 2 105 ? 4.05574   20.30551  18.51280 1.000 157.60560 ? 106 TRP B CA   1 
ATOM 2260 C C    . TRP B 2 105 ? 4.09185   21.78961  18.18453 1.000 135.99991 ? 106 TRP B C    1 
ATOM 2261 O O    . TRP B 2 105 ? 4.98321   22.51396  18.63741 1.000 154.85688 ? 106 TRP B O    1 
ATOM 2262 C CB   . TRP B 2 105 ? 3.40030   20.09437  19.88115 1.000 160.59593 ? 106 TRP B CB   1 
ATOM 2263 C CG   . TRP B 2 105 ? 3.11932   18.66065  20.19567 1.000 138.99898 ? 106 TRP B CG   1 
ATOM 2264 C CD1  . TRP B 2 105 ? 3.94342   17.78513  20.83872 1.000 177.52694 ? 106 TRP B CD1  1 
ATOM 2265 C CD2  . TRP B 2 105 ? 1.92407   17.93552  19.88893 1.000 125.95362 ? 106 TRP B CD2  1 
ATOM 2266 N NE1  . TRP B 2 105 ? 3.34074   16.55470  20.93980 1.000 184.81532 ? 106 TRP B NE1  1 
ATOM 2267 C CE2  . TRP B 2 105 ? 2.09964   16.62093  20.36385 1.000 152.30753 ? 106 TRP B CE2  1 
ATOM 2268 C CE3  . TRP B 2 105 ? 0.72921   18.26566  19.24352 1.000 140.36728 ? 106 TRP B CE3  1 
ATOM 2269 C CZ2  . TRP B 2 105 ? 1.12184   15.63916  20.22237 1.000 159.83404 ? 106 TRP B CZ2  1 
ATOM 2270 C CZ3  . TRP B 2 105 ? -0.24551  17.29233  19.11262 1.000 131.69795 ? 106 TRP B CZ3  1 
ATOM 2271 C CH2  . TRP B 2 105 ? -0.03442  15.98893  19.58110 1.000 151.60761 ? 106 TRP B CH2  1 
ATOM 2272 H H    . TRP B 2 105 ? 5.96727   20.23447  18.94855 1.000 183.41763 ? 106 TRP B H    1 
ATOM 2273 H HA   . TRP B 2 105 ? 3.51355   19.84936  17.85034 1.000 191.67232 ? 106 TRP B HA   1 
ATOM 2274 H HB2  . TRP B 2 105 ? 3.99296   20.43800  20.56786 1.000 195.26072 ? 106 TRP B HB2  1 
ATOM 2275 H HB3  . TRP B 2 105 ? 2.55691   20.57311  19.90084 1.000 195.26072 ? 106 TRP B HB3  1 
ATOM 2276 H HD1  . TRP B 2 105 ? 4.79073   17.99107  21.16205 1.000 215.57793 ? 106 TRP B HD1  1 
ATOM 2277 H HE1  . TRP B 2 105 ? 3.68620   15.85692  21.30499 1.000 224.32399 ? 106 TRP B HE1  1 
ATOM 2278 H HE3  . TRP B 2 105 ? 0.59198   19.12239  18.90873 1.000 170.98634 ? 106 TRP B HE3  1 
ATOM 2279 H HZ2  . TRP B 2 105 ? 1.25028   14.77882  20.55133 1.000 194.34645 ? 106 TRP B HZ2  1 
ATOM 2280 H HZ3  . TRP B 2 105 ? -1.05433  17.50693  18.70684 1.000 160.58314 ? 106 TRP B HZ3  1 
ATOM 2281 H HH2  . TRP B 2 105 ? -0.69531  15.34724  19.45317 1.000 184.47474 ? 106 TRP B HH2  1 
ATOM 2282 N N    . GLY B 2 106 ? 3.12230   22.23326  17.39172 1.000 140.07810 ? 107 GLY B N    1 
ATOM 2283 C CA   . GLY B 2 106 ? 2.92124   23.64590  17.15566 1.000 142.26569 ? 107 GLY B CA   1 
ATOM 2284 C C    . GLY B 2 106 ? 2.42174   24.36596  18.39528 1.000 163.97864 ? 107 GLY B C    1 
ATOM 2285 O O    . GLY B 2 106 ? 2.27086   23.80001  19.47878 1.000 171.07289 ? 107 GLY B O    1 
ATOM 2286 H H    . GLY B 2 106 ? 2.56474   21.72646  16.97715 1.000 170.63933 ? 107 GLY B H    1 
ATOM 2287 H HA2  . GLY B 2 106 ? 3.76000   24.04975  16.88311 1.000 173.26443 ? 107 GLY B HA2  1 
ATOM 2288 H HA3  . GLY B 2 106 ? 2.26878   23.76476  16.44779 1.000 173.26443 ? 107 GLY B HA3  1 
ATOM 2289 N N    . GLN B 2 107 ? 2.15835   25.66267  18.21959 1.000 158.69017 ? 108 GLN B N    1 
ATOM 2290 C CA   . GLN B 2 107 ? 1.70604   26.47955  19.33825 1.000 175.37181 ? 108 GLN B CA   1 
ATOM 2291 C C    . GLN B 2 107 ? 0.25996   26.18382  19.71757 1.000 165.83256 ? 108 GLN B C    1 
ATOM 2292 O O    . GLN B 2 107 ? -0.16368  26.54177  20.82190 1.000 182.92272 ? 108 GLN B O    1 
ATOM 2293 C CB   . GLN B 2 107 ? 1.85142   27.96564  18.99790 1.000 189.99504 ? 108 GLN B CB   1 
ATOM 2294 C CG   . GLN B 2 107 ? 3.24143   28.39081  18.52985 1.000 153.36577 ? 108 GLN B CG   1 
ATOM 2295 C CD   . GLN B 2 107 ? 4.30854   28.22649  19.59182 1.000 176.19106 ? 108 GLN B CD   1 
ATOM 2296 O OE1  . GLN B 2 107 ? 4.03768   27.77901  20.70482 1.000 211.83806 ? 108 GLN B OE1  1 
ATOM 2297 N NE2  . GLN B 2 107 ? 5.53714   28.59854  19.24919 1.000 162.39178 ? 108 GLN B NE2  1 
ATOM 2298 H H    . GLN B 2 107 ? 2.23327   26.08394  17.47359 1.000 192.97381 ? 108 GLN B H    1 
ATOM 2299 H HA   . GLN B 2 107 ? 2.26673   26.28929  20.10659 1.000 212.99178 ? 108 GLN B HA   1 
ATOM 2300 H HB2  . GLN B 2 107 ? 1.22758   28.17957  18.28659 1.000 230.53965 ? 108 GLN B HB2  1 
ATOM 2301 H HB3  . GLN B 2 107 ? 1.64103   28.48358  19.79061 1.000 230.53965 ? 108 GLN B HB3  1 
ATOM 2302 H HG2  . GLN B 2 107 ? 3.49519   27.84839  17.76677 1.000 186.58453 ? 108 GLN B HG2  1 
ATOM 2303 H HG3  . GLN B 2 107 ? 3.21482   29.32697  18.27727 1.000 186.58453 ? 108 GLN B HG3  1 
ATOM 2304 H HE21 . GLN B 2 107 ? 5.68804   28.91124  18.46239 1.000 197.41574 ? 108 GLN B HE21 1 
ATOM 2305 H HE22 . GLN B 2 107 ? 6.18150   28.52665  19.81420 1.000 197.41574 ? 108 GLN B HE22 1 
ATOM 2306 N N    . GLY B 2 108 ? -0.49960  25.54045  18.83436 1.000 145.97832 ? 109 GLY B N    1 
ATOM 2307 C CA   . GLY B 2 108 ? -1.91766  25.32713  19.04859 1.000 163.33469 ? 109 GLY B CA   1 
ATOM 2308 C C    . GLY B 2 108 ? -2.75201  26.57643  18.85055 1.000 165.72081 ? 109 GLY B C    1 
ATOM 2309 O O    . GLY B 2 108 ? -2.21222  27.67135  18.66376 1.000 222.52302 ? 109 GLY B O    1 
ATOM 2310 H H    . GLY B 2 108 ? -0.20864  25.21475  18.09351 1.000 177.71958 ? 109 GLY B H    1 
ATOM 2311 H HA2  . GLY B 2 108 ? -2.23374  24.65215  18.42779 1.000 198.54723 ? 109 GLY B HA2  1 
ATOM 2312 H HA3  . GLY B 2 108 ? -2.05713  25.01226  19.95540 1.000 198.54723 ? 109 GLY B HA3  1 
ATOM 2313 N N    . THR B 2 109 ? -4.07421  26.42009  18.89118 1.000 145.74193 ? 110 THR B N    1 
ATOM 2314 C CA   . THR B 2 109 ? -5.01298  27.53472  18.87126 1.000 143.88110 ? 110 THR B CA   1 
ATOM 2315 C C    . THR B 2 109 ? -5.96262  27.41950  20.05624 1.000 162.87309 ? 110 THR B C    1 
ATOM 2316 O O    . THR B 2 109 ? -6.56907  26.36510  20.27286 1.000 207.00446 ? 110 THR B O    1 
ATOM 2317 C CB   . THR B 2 109 ? -5.78744  27.59141  17.54479 1.000 164.72490 ? 110 THR B CB   1 
ATOM 2318 O OG1  . THR B 2 109 ? -6.57780  28.78576  17.50209 1.000 172.07079 ? 110 THR B OG1  1 
ATOM 2319 C CG2  . THR B 2 109 ? -6.68017  26.37003  17.36082 1.000 189.78606 ? 110 THR B CG2  1 
ATOM 2320 H H    . THR B 2 109 ? -4.46117  25.65314  18.93176 1.000 177.43592 ? 110 THR B H    1 
ATOM 2321 H HA   . THR B 2 109 ? -4.52706  28.36891  18.96562 1.000 175.20292 ? 110 THR B HA   1 
ATOM 2322 H HB   . THR B 2 109 ? -5.15407  27.59569  16.81013 1.000 200.21548 ? 110 THR B HB   1 
ATOM 2323 H HG1  . THR B 2 109 ? -6.07792  29.46008  17.47025 1.000 209.03055 ? 110 THR B HG1  1 
ATOM 2324 H HG21 . THR B 2 109 ? -7.11191  26.40238  16.49280 1.000 230.28887 ? 110 THR B HG21 1 
ATOM 2325 H HG22 . THR B 2 109 ? -7.36165  26.35024  18.05082 1.000 230.28887 ? 110 THR B HG22 1 
ATOM 2326 H HG23 . THR B 2 109 ? -6.14998  25.55982  17.41870 1.000 230.28887 ? 110 THR B HG23 1 
ATOM 2327 N N    . GLN B 2 110 ? -6.03787  28.48589  20.85000 1.000 161.41231 ? 111 GLN B N    1 
ATOM 2328 C CA   . GLN B 2 110 ? -6.90315  28.51302  22.02345 1.000 159.83095 ? 111 GLN B CA   1 
ATOM 2329 C C    . GLN B 2 110 ? -8.37042  28.58825  21.61672 1.000 164.45389 ? 111 GLN B C    1 
ATOM 2330 O O    . GLN B 2 110 ? -8.76625  29.47609  20.85673 1.000 181.72245 ? 111 GLN B O    1 
ATOM 2331 C CB   . GLN B 2 110 ? -6.54171  29.71529  22.89654 1.000 195.86829 ? 111 GLN B CB   1 
ATOM 2332 C CG   . GLN B 2 110 ? -7.39725  29.88715  24.14339 1.000 181.93644 ? 111 GLN B CG   1 
ATOM 2333 C CD   . GLN B 2 110 ? -7.17461  28.79388  25.16528 1.000 145.37124 ? 111 GLN B CD   1 
ATOM 2334 O OE1  . GLN B 2 110 ? -6.06602  28.61456  25.66946 1.000 185.40142 ? 111 GLN B OE1  1 
ATOM 2335 N NE2  . GLN B 2 110 ? -8.23169  28.05536  25.47798 1.000 185.33690 ? 111 GLN B NE2  1 
ATOM 2336 H H    . GLN B 2 110 ? -5.59383  29.21241  20.72917 1.000 196.24037 ? 111 GLN B H    1 
ATOM 2337 H HA   . GLN B 2 110 ? -6.77689  27.69778  22.53368 1.000 194.34275 ? 111 GLN B HA   1 
ATOM 2338 H HB2  . GLN B 2 110 ? -5.62133  29.61785  23.18689 1.000 237.58755 ? 111 GLN B HB2  1 
ATOM 2339 H HB3  . GLN B 2 110 ? -6.63829  30.52069  22.36465 1.000 237.58755 ? 111 GLN B HB3  1 
ATOM 2340 H HG2  . GLN B 2 110 ? -7.18022  30.73554  24.56055 1.000 220.86933 ? 111 GLN B HG2  1 
ATOM 2341 H HG3  . GLN B 2 110 ? -8.33304  29.87257  23.88847 1.000 220.86933 ? 111 GLN B HG3  1 
ATOM 2342 H HE21 . GLN B 2 110 ? -8.99070  28.21122  25.10486 1.000 224.94988 ? 111 GLN B HE21 1 
ATOM 2343 H HE22 . GLN B 2 110 ? -8.15781  27.42084  26.05376 1.000 224.94988 ? 111 GLN B HE22 1 
ATOM 2344 N N    . VAL B 2 111 ? -9.18077  27.65996  22.12352 1.000 165.80219 ? 112 VAL B N    1 
ATOM 2345 C CA   . VAL B 2 111 ? -10.63186 27.71081  21.99508 1.000 166.59167 ? 112 VAL B CA   1 
ATOM 2346 C C    . VAL B 2 111 ? -11.20676 27.88947  23.39189 1.000 176.06711 ? 112 VAL B C    1 
ATOM 2347 O O    . VAL B 2 111 ? -10.97278 27.05221  24.27757 1.000 192.89126 ? 112 VAL B O    1 
ATOM 2348 C CB   . VAL B 2 111 ? -11.18968 26.44350  21.32837 1.000 175.51847 ? 112 VAL B CB   1 
ATOM 2349 C CG1  . VAL B 2 111 ? -12.71331 26.43122  21.38091 1.000 210.67809 ? 112 VAL B CG1  1 
ATOM 2350 C CG2  . VAL B 2 111 ? -10.69929 26.33736  19.89398 1.000 158.66267 ? 112 VAL B CG2  1 
ATOM 2351 H H    . VAL B 2 111 ? -8.90250  26.97206  22.55822 1.000 201.50823 ? 112 VAL B H    1 
ATOM 2352 H HA   . VAL B 2 111 ? -10.88322 28.47429  21.45211 1.000 202.45561 ? 112 VAL B HA   1 
ATOM 2353 H HB   . VAL B 2 111 ? -10.86902 25.66831  21.81537 1.000 213.16776 ? 112 VAL B HB   1 
ATOM 2354 H HG11 . VAL B 2 111 ? -13.04191 25.69379  20.84321 1.000 255.35931 ? 112 VAL B HG11 1 
ATOM 2355 H HG12 . VAL B 2 111 ? -13.04817 27.27130  21.03013 1.000 255.35931 ? 112 VAL B HG12 1 
ATOM 2356 H HG13 . VAL B 2 111 ? -12.99666 26.32096  22.30202 1.000 255.35931 ? 112 VAL B HG13 1 
ATOM 2357 H HG21 . VAL B 2 111 ? -9.72937  26.32499  19.89192 1.000 192.94081 ? 112 VAL B HG21 1 
ATOM 2358 H HG22 . VAL B 2 111 ? -11.02140 27.10274  19.39265 1.000 192.94081 ? 112 VAL B HG22 1 
ATOM 2359 H HG23 . VAL B 2 111 ? -11.04136 25.51816  19.50308 1.000 192.94081 ? 112 VAL B HG23 1 
ATOM 2360 N N    . THR B 2 112 ? -11.96611 28.96910  23.58620 1.000 173.21745 ? 113 THR B N    1 
ATOM 2361 C CA   . THR B 2 112 ? -12.67608 29.22064  24.83274 1.000 188.73766 ? 113 THR B CA   1 
ATOM 2362 C C    . THR B 2 112 ? -14.15704 29.37089  24.52214 1.000 204.25646 ? 113 THR B C    1 
ATOM 2363 O O    . THR B 2 112 ? -14.54397 30.22823  23.71851 1.000 208.48994 ? 113 THR B O    1 
ATOM 2364 C CB   . THR B 2 112 ? -12.15104 30.48324  25.52269 1.000 168.11439 ? 113 THR B CB   1 
ATOM 2365 O OG1  . THR B 2 112 ? -10.76243 30.32323  25.84032 1.000 156.84985 ? 113 THR B OG1  1 
ATOM 2366 C CG2  . THR B 2 112 ? -12.93638 30.76550  26.80131 1.000 224.94922 ? 113 THR B CG2  1 
ATOM 2367 H H    . THR B 2 112 ? -12.08548 29.58168  22.99450 1.000 210.40654 ? 113 THR B H    1 
ATOM 2368 H HA   . THR B 2 112 ? -12.55394 28.46775  25.43203 1.000 229.03079 ? 113 THR B HA   1 
ATOM 2369 H HB   . THR B 2 112 ? -12.25744 31.24094  24.92648 1.000 204.28288 ? 113 THR B HB   1 
ATOM 2370 H HG1  . THR B 2 112 ? -10.34571 31.03302  25.67261 1.000 190.76542 ? 113 THR B HG1  1 
ATOM 2371 H HG21 . THR B 2 112 ? -12.54428 31.51737  27.27233 1.000 272.48467 ? 113 THR B HG21 1 
ATOM 2372 H HG22 . THR B 2 112 ? -12.91853 29.98740  27.38022 1.000 272.48467 ? 113 THR B HG22 1 
ATOM 2373 H HG23 . THR B 2 112 ? -13.85825 30.97574  26.58485 1.000 272.48467 ? 113 THR B HG23 1 
ATOM 2374 N N    . VAL B 2 113 ? -14.97275 28.54295  25.16663 1.000 176.85648 ? 114 VAL B N    1 
ATOM 2375 C CA   . VAL B 2 113 ? -16.41883 28.52112  24.98795 1.000 169.05600 ? 114 VAL B CA   1 
ATOM 2376 C C    . VAL B 2 113 ? -17.04305 28.98305  26.29486 1.000 192.54700 ? 114 VAL B C    1 
ATOM 2377 O O    . VAL B 2 113 ? -16.78827 28.38800  27.34980 1.000 185.10588 ? 114 VAL B O    1 
ATOM 2378 C CB   . VAL B 2 113 ? -16.92564 27.12546  24.59416 1.000 179.30808 ? 114 VAL B CB   1 
ATOM 2379 C CG1  . VAL B 2 113 ? -18.40470 27.18017  24.24475 1.000 225.74449 ? 114 VAL B CG1  1 
ATOM 2380 C CG2  . VAL B 2 113 ? -16.11925 26.57824  23.42802 1.000 163.27831 ? 114 VAL B CG2  1 
ATOM 2381 H H    . VAL B 2 113 ? -14.69905 27.96016  25.73675 1.000 214.77338 ? 114 VAL B H    1 
ATOM 2382 H HA   . VAL B 2 113 ? -16.66961 29.14000  24.28439 1.000 205.41281 ? 114 VAL B HA   1 
ATOM 2383 H HB   . VAL B 2 113 ? -16.81382 26.52390  25.34684 1.000 217.71530 ? 114 VAL B HB   1 
ATOM 2384 H HG11 . VAL B 2 113 ? -18.90332 27.46688  25.02583 1.000 273.43899 ? 114 VAL B HG11 1 
ATOM 2385 H HG12 . VAL B 2 113 ? -18.53472 27.81096  23.51942 1.000 273.43899 ? 114 VAL B HG12 1 
ATOM 2386 H HG13 . VAL B 2 113 ? -18.69749 26.29676  23.97133 1.000 273.43899 ? 114 VAL B HG13 1 
ATOM 2387 H HG21 . VAL B 2 113 ? -15.18056 26.56441  23.67207 1.000 198.47958 ? 114 VAL B HG21 1 
ATOM 2388 H HG22 . VAL B 2 113 ? -16.25196 27.15052  22.65615 1.000 198.47958 ? 114 VAL B HG22 1 
ATOM 2389 H HG23 . VAL B 2 113 ? -16.42254 25.67865  23.22888 1.000 198.47958 ? 114 VAL B HG23 1 
ATOM 2390 N N    . SER B 2 114 ? -17.85945 30.03262  26.23644 1.000 181.32797 ? 115 SER B N    1 
ATOM 2391 C CA   . SER B 2 114 ? -18.51965 30.53115  27.43435 1.000 178.49996 ? 115 SER B CA   1 
ATOM 2392 C C    . SER B 2 114 ? -20.02941 30.42802  27.27186 1.000 171.42506 ? 115 SER B C    1 
ATOM 2393 O O    . SER B 2 114 ? -20.56506 30.59200  26.17383 1.000 155.82190 ? 115 SER B O    1 
ATOM 2394 C CB   . SER B 2 114 ? -18.11786 31.98683  27.72472 1.000 194.23627 ? 115 SER B CB   1 
ATOM 2395 O OG   . SER B 2 114 ? -18.56548 32.86036  26.70348 1.000 222.89831 ? 115 SER B OG   1 
ATOM 2396 H H    . SER B 2 114 ? -18.04359 30.46775  25.51786 1.000 220.13917 ? 115 SER B H    1 
ATOM 2397 H HA   . SER B 2 114 ? -18.26277 29.99103  28.19802 1.000 216.74556 ? 115 SER B HA   1 
ATOM 2398 H HB2  . SER B 2 114 ? -18.51472 32.25957  28.56675 1.000 235.62913 ? 115 SER B HB2  1 
ATOM 2399 H HB3  . SER B 2 114 ? -17.15095 32.03987  27.78107 1.000 235.62913 ? 115 SER B HB3  1 
ATOM 2400 H HG   . SER B 2 114 ? -18.30204 33.64272  26.85874 1.000 270.02358 ? 115 SER B HG   1 
ATOM 2401 N N    . SER B 2 115 ? -20.71180 30.19566  28.39002 1.000 165.52852 ? 116 SER B N    1 
ATOM 2402 C CA   . SER B 2 115 ? -22.17120 30.18935  28.42556 1.000 196.30481 ? 116 SER B CA   1 
ATOM 2403 C C    . SER B 2 115 ? -22.74657 31.60291  28.47507 1.000 202.11395 ? 116 SER B C    1 
ATOM 2404 O O    . SER B 2 115 ? -22.10449 32.52980  28.96755 1.000 198.93563 ? 116 SER B O    1 
ATOM 2405 C CB   . SER B 2 115 ? -22.66641 29.37033  29.62458 1.000 190.00986 ? 116 SER B CB   1 
ATOM 2406 O OG   . SER B 2 115 ? -21.81449 29.52337  30.74708 1.000 196.40851 ? 116 SER B OG   1 
ATOM 2407 H H    . SER B 2 115 ? -20.34742 30.03657  29.15260 1.000 201.17983 ? 116 SER B H    1 
ATOM 2408 H HA   . SER B 2 115 ? -22.50061 29.77526  27.61259 1.000 238.11137 ? 116 SER B HA   1 
ATOM 2409 H HB2  . SER B 2 115 ? -23.55655 29.67255  29.86379 1.000 230.55743 ? 116 SER B HB2  1 
ATOM 2410 H HB3  . SER B 2 115 ? -22.69007 28.43326  29.37513 1.000 230.55743 ? 116 SER B HB3  1 
ATOM 2411 H HG   . SER B 2 115 ? -22.14032 29.12569  31.41138 1.000 238.23581 ? 116 SER B HG   1 
# 
