data_9EID
# 
_entry.id   9EID 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EID         pdb_00009eid 10.2210/pdb9eid/pdb 
WWPDB D_1000290540 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EID 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 hausinge@msu.edu Robert Hausinger P 'principal investigator/group leader' 0000-0002-3643-2054 
3 hujian1@msu.edu  Jian   Hu        ? 'principal investigator/group leader' 0000-0001-6657-9826 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gatreddi, S.'    1 ? 
'Hausinger, R.P.' 2 ? 
'Hu, J.'          3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural Basis for Catalysis and Substrate Specificity of a LarA Racemase with a Broad Substrate Spectrum.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.11.28.625916 
_citation.pdbx_database_id_PubMed   39651260 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gatreddi, S.'        1 ? 
primary 'Urdiain-Arraiza, J.' 2 ? 
primary 'Desguin, B.'         3 ? 
primary 'Hausinger, R.P.'     4 ? 
primary 'Hu, J.'              5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'A broad-substrate spectrum lactate racemase A'                                            45856.727 1   ? ? ? ? 
2 non-polymer syn '(2R)-2-oxidanylbutanoic acid'                                                             104.105   1   ? ? ? ? 
3 non-polymer syn '3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium' 396.353   1   ? ? ? ? 
4 non-polymer syn 'NICKEL (II) ION'                                                                          58.693    1   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                                                            94.971    2   ? ? ? ? 
6 water       nat water                                                                                      18.015    528 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;ARVTLDYGKTGLNVDLPDDRTLPPLTIRPAPPLDDPEAEVVRCLAEPIGSPPLLDLARGKRSACILVCDITRPVPNPVLL
RPILRTLHAAGLATQDILILVATGLHRPSTPAEKVEMLSEEIARTYRVEDHYGTRLEEHTYLGTTPNGVPAWIDSRYVQA
DLKIATGLIEPHLMAGYSGGRKLICPGIAAFETVKLWHGPRFLEHPLADCGFLEGNPVHEENTRIARMAGCDFIVNVTLD
GARRITSVVAGDMEQAFLKGVAFVETVVKAAVPAPVDVVVTSSAGHPLDLTFYQAVKGLTGALPIVKPGGTIVIAAALAE
GLGSPEFQSLFEEHPTLEGFMEAILKEESFTVDQWQLEELAKVRRKARVKFVSDGVPAAVLSRCHVEPVATVELAVAQAL
EQYGPEARVAVIPKGPYVLPVVDPT
;
_entity_poly.pdbx_seq_one_letter_code_can   
;ARVTLDYGKTGLNVDLPDDRTLPPLTIRPAPPLDDPEAEVVRCLAEPIGSPPLLDLARGKRSACILVCDITRPVPNPVLL
RPILRTLHAAGLATQDILILVATGLHRPSTPAEKVEMLSEEIARTYRVEDHYGTRLEEHTYLGTTPNGVPAWIDSRYVQA
DLKIATGLIEPHLMAGYSGGRKLICPGIAAFETVKLWHGPRFLEHPLADCGFLEGNPVHEENTRIARMAGCDFIVNVTLD
GARRITSVVAGDMEQAFLKGVAFVETVVKAAVPAPVDVVVTSSAGHPLDLTFYQAVKGLTGALPIVKPGGTIVIAAALAE
GLGSPEFQSLFEEHPTLEGFMEAILKEESFTVDQWQLEELAKVRRKARVKFVSDGVPAAVLSRCHVEPVATVELAVAQAL
EQYGPEARVAVIPKGPYVLPVVDPT
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(2R)-2-oxidanylbutanoic acid'                                                             UCU 
3 '3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium' 4EY 
4 'NICKEL (II) ION'                                                                          NI  
5 'PHOSPHATE ION'                                                                            PO4 
6 water                                                                                      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ARG n 
1 3   VAL n 
1 4   THR n 
1 5   LEU n 
1 6   ASP n 
1 7   TYR n 
1 8   GLY n 
1 9   LYS n 
1 10  THR n 
1 11  GLY n 
1 12  LEU n 
1 13  ASN n 
1 14  VAL n 
1 15  ASP n 
1 16  LEU n 
1 17  PRO n 
1 18  ASP n 
1 19  ASP n 
1 20  ARG n 
1 21  THR n 
1 22  LEU n 
1 23  PRO n 
1 24  PRO n 
1 25  LEU n 
1 26  THR n 
1 27  ILE n 
1 28  ARG n 
1 29  PRO n 
1 30  ALA n 
1 31  PRO n 
1 32  PRO n 
1 33  LEU n 
1 34  ASP n 
1 35  ASP n 
1 36  PRO n 
1 37  GLU n 
1 38  ALA n 
1 39  GLU n 
1 40  VAL n 
1 41  VAL n 
1 42  ARG n 
1 43  CYS n 
1 44  LEU n 
1 45  ALA n 
1 46  GLU n 
1 47  PRO n 
1 48  ILE n 
1 49  GLY n 
1 50  SER n 
1 51  PRO n 
1 52  PRO n 
1 53  LEU n 
1 54  LEU n 
1 55  ASP n 
1 56  LEU n 
1 57  ALA n 
1 58  ARG n 
1 59  GLY n 
1 60  LYS n 
1 61  ARG n 
1 62  SER n 
1 63  ALA n 
1 64  CYS n 
1 65  ILE n 
1 66  LEU n 
1 67  VAL n 
1 68  CYS n 
1 69  ASP n 
1 70  ILE n 
1 71  THR n 
1 72  ARG n 
1 73  PRO n 
1 74  VAL n 
1 75  PRO n 
1 76  ASN n 
1 77  PRO n 
1 78  VAL n 
1 79  LEU n 
1 80  LEU n 
1 81  ARG n 
1 82  PRO n 
1 83  ILE n 
1 84  LEU n 
1 85  ARG n 
1 86  THR n 
1 87  LEU n 
1 88  HIS n 
1 89  ALA n 
1 90  ALA n 
1 91  GLY n 
1 92  LEU n 
1 93  ALA n 
1 94  THR n 
1 95  GLN n 
1 96  ASP n 
1 97  ILE n 
1 98  LEU n 
1 99  ILE n 
1 100 LEU n 
1 101 VAL n 
1 102 ALA n 
1 103 THR n 
1 104 GLY n 
1 105 LEU n 
1 106 HIS n 
1 107 ARG n 
1 108 PRO n 
1 109 SER n 
1 110 THR n 
1 111 PRO n 
1 112 ALA n 
1 113 GLU n 
1 114 LYS n 
1 115 VAL n 
1 116 GLU n 
1 117 MET n 
1 118 LEU n 
1 119 SER n 
1 120 GLU n 
1 121 GLU n 
1 122 ILE n 
1 123 ALA n 
1 124 ARG n 
1 125 THR n 
1 126 TYR n 
1 127 ARG n 
1 128 VAL n 
1 129 GLU n 
1 130 ASP n 
1 131 HIS n 
1 132 TYR n 
1 133 GLY n 
1 134 THR n 
1 135 ARG n 
1 136 LEU n 
1 137 GLU n 
1 138 GLU n 
1 139 HIS n 
1 140 THR n 
1 141 TYR n 
1 142 LEU n 
1 143 GLY n 
1 144 THR n 
1 145 THR n 
1 146 PRO n 
1 147 ASN n 
1 148 GLY n 
1 149 VAL n 
1 150 PRO n 
1 151 ALA n 
1 152 TRP n 
1 153 ILE n 
1 154 ASP n 
1 155 SER n 
1 156 ARG n 
1 157 TYR n 
1 158 VAL n 
1 159 GLN n 
1 160 ALA n 
1 161 ASP n 
1 162 LEU n 
1 163 LYS n 
1 164 ILE n 
1 165 ALA n 
1 166 THR n 
1 167 GLY n 
1 168 LEU n 
1 169 ILE n 
1 170 GLU n 
1 171 PRO n 
1 172 HIS n 
1 173 LEU n 
1 174 MET n 
1 175 ALA n 
1 176 GLY n 
1 177 TYR n 
1 178 SER n 
1 179 GLY n 
1 180 GLY n 
1 181 ARG n 
1 182 LYS n 
1 183 LEU n 
1 184 ILE n 
1 185 CYS n 
1 186 PRO n 
1 187 GLY n 
1 188 ILE n 
1 189 ALA n 
1 190 ALA n 
1 191 PHE n 
1 192 GLU n 
1 193 THR n 
1 194 VAL n 
1 195 LYS n 
1 196 LEU n 
1 197 TRP n 
1 198 HIS n 
1 199 GLY n 
1 200 PRO n 
1 201 ARG n 
1 202 PHE n 
1 203 LEU n 
1 204 GLU n 
1 205 HIS n 
1 206 PRO n 
1 207 LEU n 
1 208 ALA n 
1 209 ASP n 
1 210 CYS n 
1 211 GLY n 
1 212 PHE n 
1 213 LEU n 
1 214 GLU n 
1 215 GLY n 
1 216 ASN n 
1 217 PRO n 
1 218 VAL n 
1 219 HIS n 
1 220 GLU n 
1 221 GLU n 
1 222 ASN n 
1 223 THR n 
1 224 ARG n 
1 225 ILE n 
1 226 ALA n 
1 227 ARG n 
1 228 MET n 
1 229 ALA n 
1 230 GLY n 
1 231 CYS n 
1 232 ASP n 
1 233 PHE n 
1 234 ILE n 
1 235 VAL n 
1 236 ASN n 
1 237 VAL n 
1 238 THR n 
1 239 LEU n 
1 240 ASP n 
1 241 GLY n 
1 242 ALA n 
1 243 ARG n 
1 244 ARG n 
1 245 ILE n 
1 246 THR n 
1 247 SER n 
1 248 VAL n 
1 249 VAL n 
1 250 ALA n 
1 251 GLY n 
1 252 ASP n 
1 253 MET n 
1 254 GLU n 
1 255 GLN n 
1 256 ALA n 
1 257 PHE n 
1 258 LEU n 
1 259 LYS n 
1 260 GLY n 
1 261 VAL n 
1 262 ALA n 
1 263 PHE n 
1 264 VAL n 
1 265 GLU n 
1 266 THR n 
1 267 VAL n 
1 268 VAL n 
1 269 LYS n 
1 270 ALA n 
1 271 ALA n 
1 272 VAL n 
1 273 PRO n 
1 274 ALA n 
1 275 PRO n 
1 276 VAL n 
1 277 ASP n 
1 278 VAL n 
1 279 VAL n 
1 280 VAL n 
1 281 THR n 
1 282 SER n 
1 283 SER n 
1 284 ALA n 
1 285 GLY n 
1 286 HIS n 
1 287 PRO n 
1 288 LEU n 
1 289 ASP n 
1 290 LEU n 
1 291 THR n 
1 292 PHE n 
1 293 TYR n 
1 294 GLN n 
1 295 ALA n 
1 296 VAL n 
1 297 LYS n 
1 298 GLY n 
1 299 LEU n 
1 300 THR n 
1 301 GLY n 
1 302 ALA n 
1 303 LEU n 
1 304 PRO n 
1 305 ILE n 
1 306 VAL n 
1 307 LYS n 
1 308 PRO n 
1 309 GLY n 
1 310 GLY n 
1 311 THR n 
1 312 ILE n 
1 313 VAL n 
1 314 ILE n 
1 315 ALA n 
1 316 ALA n 
1 317 ALA n 
1 318 LEU n 
1 319 ALA n 
1 320 GLU n 
1 321 GLY n 
1 322 LEU n 
1 323 GLY n 
1 324 SER n 
1 325 PRO n 
1 326 GLU n 
1 327 PHE n 
1 328 GLN n 
1 329 SER n 
1 330 LEU n 
1 331 PHE n 
1 332 GLU n 
1 333 GLU n 
1 334 HIS n 
1 335 PRO n 
1 336 THR n 
1 337 LEU n 
1 338 GLU n 
1 339 GLY n 
1 340 PHE n 
1 341 MET n 
1 342 GLU n 
1 343 ALA n 
1 344 ILE n 
1 345 LEU n 
1 346 LYS n 
1 347 GLU n 
1 348 GLU n 
1 349 SER n 
1 350 PHE n 
1 351 THR n 
1 352 VAL n 
1 353 ASP n 
1 354 GLN n 
1 355 TRP n 
1 356 GLN n 
1 357 LEU n 
1 358 GLU n 
1 359 GLU n 
1 360 LEU n 
1 361 ALA n 
1 362 LYS n 
1 363 VAL n 
1 364 ARG n 
1 365 ARG n 
1 366 LYS n 
1 367 ALA n 
1 368 ARG n 
1 369 VAL n 
1 370 LYS n 
1 371 PHE n 
1 372 VAL n 
1 373 SER n 
1 374 ASP n 
1 375 GLY n 
1 376 VAL n 
1 377 PRO n 
1 378 ALA n 
1 379 ALA n 
1 380 VAL n 
1 381 LEU n 
1 382 SER n 
1 383 ARG n 
1 384 CYS n 
1 385 HIS n 
1 386 VAL n 
1 387 GLU n 
1 388 PRO n 
1 389 VAL n 
1 390 ALA n 
1 391 THR n 
1 392 VAL n 
1 393 GLU n 
1 394 LEU n 
1 395 ALA n 
1 396 VAL n 
1 397 ALA n 
1 398 GLN n 
1 399 ALA n 
1 400 LEU n 
1 401 GLU n 
1 402 GLN n 
1 403 TYR n 
1 404 GLY n 
1 405 PRO n 
1 406 GLU n 
1 407 ALA n 
1 408 ARG n 
1 409 VAL n 
1 410 ALA n 
1 411 VAL n 
1 412 ILE n 
1 413 PRO n 
1 414 LYS n 
1 415 GLY n 
1 416 PRO n 
1 417 TYR n 
1 418 VAL n 
1 419 LEU n 
1 420 PRO n 
1 421 VAL n 
1 422 VAL n 
1 423 ASP n 
1 424 PRO n 
1 425 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   425 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Isop_3476 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Isosphaera pallida' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     128 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Lactococcus lactis' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     1358 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               NZ3900 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
4EY non-polymer         . '3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium' 
'Dithiodinicotinic acid mononucleotide' 'C12 H15 N O8 P S2 1' 396.353 
ALA 'L-peptide linking' y ALANINE                                                                                    ? 
'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE                                                                                   ? 
'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                 ? 
'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                            ? 
'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                   ? 
'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                  ? 
'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                            ? 
'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE                                                                                    ? 
'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                  ? 
'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER                                                                                      ? 'H2 O' 
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                 ? 
'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                    ? 
'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE                                                                                     ? 
'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE                                                                                 ? 
'C5 H11 N O2 S'       149.211 
NI  non-polymer         . 'NICKEL (II) ION'                                                                          ? 'Ni 2' 
58.693  
PHE 'L-peptide linking' y PHENYLALANINE                                                                              ? 
'C9 H11 N O2'         165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                                            ? 'O4 P -3' 
94.971  
PRO 'L-peptide linking' y PROLINE                                                                                    ? 
'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE                                                                                     ? 
'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE                                                                                  ? 
'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                 ? 
'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                   ? 
'C9 H11 N O3'         181.189 
UCU non-polymer         . '(2R)-2-oxidanylbutanoic acid'                                                             
'(R)-2-Hydroxybutanoic acid'            'C4 H8 O3'            104.105 
VAL 'L-peptide linking' y VALINE                                                                                     ? 
'C5 H11 N O2'         117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   2   2   ALA ALA A . n 
A 1 2   ARG 2   3   3   ARG ARG A . n 
A 1 3   VAL 3   4   4   VAL VAL A . n 
A 1 4   THR 4   5   5   THR THR A . n 
A 1 5   LEU 5   6   6   LEU LEU A . n 
A 1 6   ASP 6   7   7   ASP ASP A . n 
A 1 7   TYR 7   8   8   TYR TYR A . n 
A 1 8   GLY 8   9   9   GLY GLY A . n 
A 1 9   LYS 9   10  10  LYS LYS A . n 
A 1 10  THR 10  11  11  THR THR A . n 
A 1 11  GLY 11  12  12  GLY GLY A . n 
A 1 12  LEU 12  13  13  LEU LEU A . n 
A 1 13  ASN 13  14  14  ASN ASN A . n 
A 1 14  VAL 14  15  15  VAL VAL A . n 
A 1 15  ASP 15  16  16  ASP ASP A . n 
A 1 16  LEU 16  17  17  LEU LEU A . n 
A 1 17  PRO 17  18  18  PRO PRO A . n 
A 1 18  ASP 18  19  19  ASP ASP A . n 
A 1 19  ASP 19  20  20  ASP ASP A . n 
A 1 20  ARG 20  21  21  ARG ARG A . n 
A 1 21  THR 21  22  22  THR THR A . n 
A 1 22  LEU 22  23  23  LEU LEU A . n 
A 1 23  PRO 23  24  24  PRO PRO A . n 
A 1 24  PRO 24  25  25  PRO PRO A . n 
A 1 25  LEU 25  26  26  LEU LEU A . n 
A 1 26  THR 26  27  27  THR THR A . n 
A 1 27  ILE 27  28  28  ILE ILE A . n 
A 1 28  ARG 28  29  29  ARG ARG A . n 
A 1 29  PRO 29  30  30  PRO PRO A . n 
A 1 30  ALA 30  31  31  ALA ALA A . n 
A 1 31  PRO 31  32  32  PRO PRO A . n 
A 1 32  PRO 32  33  33  PRO PRO A . n 
A 1 33  LEU 33  34  34  LEU LEU A . n 
A 1 34  ASP 34  35  35  ASP ASP A . n 
A 1 35  ASP 35  36  36  ASP ASP A . n 
A 1 36  PRO 36  37  37  PRO PRO A . n 
A 1 37  GLU 37  38  38  GLU GLU A . n 
A 1 38  ALA 38  39  39  ALA ALA A . n 
A 1 39  GLU 39  40  40  GLU GLU A . n 
A 1 40  VAL 40  41  41  VAL VAL A . n 
A 1 41  VAL 41  42  42  VAL VAL A . n 
A 1 42  ARG 42  43  43  ARG ARG A . n 
A 1 43  CYS 43  44  44  CYS CYS A . n 
A 1 44  LEU 44  45  45  LEU LEU A . n 
A 1 45  ALA 45  46  46  ALA ALA A . n 
A 1 46  GLU 46  47  47  GLU GLU A . n 
A 1 47  PRO 47  48  48  PRO PRO A . n 
A 1 48  ILE 48  49  49  ILE ILE A . n 
A 1 49  GLY 49  50  50  GLY GLY A . n 
A 1 50  SER 50  51  51  SER SER A . n 
A 1 51  PRO 51  52  52  PRO PRO A . n 
A 1 52  PRO 52  53  53  PRO PRO A . n 
A 1 53  LEU 53  54  54  LEU LEU A . n 
A 1 54  LEU 54  55  55  LEU LEU A . n 
A 1 55  ASP 55  56  56  ASP ASP A . n 
A 1 56  LEU 56  57  57  LEU LEU A . n 
A 1 57  ALA 57  58  58  ALA ALA A . n 
A 1 58  ARG 58  59  59  ARG ARG A . n 
A 1 59  GLY 59  60  60  GLY GLY A . n 
A 1 60  LYS 60  61  61  LYS LYS A . n 
A 1 61  ARG 61  62  62  ARG ARG A . n 
A 1 62  SER 62  63  63  SER SER A . n 
A 1 63  ALA 63  64  64  ALA ALA A . n 
A 1 64  CYS 64  65  65  CYS CYS A . n 
A 1 65  ILE 65  66  66  ILE ILE A . n 
A 1 66  LEU 66  67  67  LEU LEU A . n 
A 1 67  VAL 67  68  68  VAL VAL A . n 
A 1 68  CYS 68  69  69  CYS CYS A . n 
A 1 69  ASP 69  70  70  ASP ASP A . n 
A 1 70  ILE 70  71  71  ILE ILE A . n 
A 1 71  THR 71  72  72  THR THR A . n 
A 1 72  ARG 72  73  73  ARG ARG A . n 
A 1 73  PRO 73  74  74  PRO PRO A . n 
A 1 74  VAL 74  75  75  VAL VAL A . n 
A 1 75  PRO 75  76  76  PRO PRO A . n 
A 1 76  ASN 76  77  77  ASN ASN A . n 
A 1 77  PRO 77  78  78  PRO PRO A . n 
A 1 78  VAL 78  79  79  VAL VAL A . n 
A 1 79  LEU 79  80  80  LEU LEU A . n 
A 1 80  LEU 80  81  81  LEU LEU A . n 
A 1 81  ARG 81  82  82  ARG ARG A . n 
A 1 82  PRO 82  83  83  PRO PRO A . n 
A 1 83  ILE 83  84  84  ILE ILE A . n 
A 1 84  LEU 84  85  85  LEU LEU A . n 
A 1 85  ARG 85  86  86  ARG ARG A . n 
A 1 86  THR 86  87  87  THR THR A . n 
A 1 87  LEU 87  88  88  LEU LEU A . n 
A 1 88  HIS 88  89  89  HIS HIS A . n 
A 1 89  ALA 89  90  90  ALA ALA A . n 
A 1 90  ALA 90  91  91  ALA ALA A . n 
A 1 91  GLY 91  92  92  GLY GLY A . n 
A 1 92  LEU 92  93  93  LEU LEU A . n 
A 1 93  ALA 93  94  94  ALA ALA A . n 
A 1 94  THR 94  95  95  THR THR A . n 
A 1 95  GLN 95  96  96  GLN GLN A . n 
A 1 96  ASP 96  97  97  ASP ASP A . n 
A 1 97  ILE 97  98  98  ILE ILE A . n 
A 1 98  LEU 98  99  99  LEU LEU A . n 
A 1 99  ILE 99  100 100 ILE ILE A . n 
A 1 100 LEU 100 101 101 LEU LEU A . n 
A 1 101 VAL 101 102 102 VAL VAL A . n 
A 1 102 ALA 102 103 103 ALA ALA A . n 
A 1 103 THR 103 104 104 THR THR A . n 
A 1 104 GLY 104 105 105 GLY GLY A . n 
A 1 105 LEU 105 106 106 LEU LEU A . n 
A 1 106 HIS 106 107 107 HIS HIS A . n 
A 1 107 ARG 107 108 108 ARG ARG A . n 
A 1 108 PRO 108 109 109 PRO PRO A . n 
A 1 109 SER 109 110 110 SER SER A . n 
A 1 110 THR 110 111 111 THR THR A . n 
A 1 111 PRO 111 112 112 PRO PRO A . n 
A 1 112 ALA 112 113 113 ALA ALA A . n 
A 1 113 GLU 113 114 114 GLU GLU A . n 
A 1 114 LYS 114 115 115 LYS LYS A . n 
A 1 115 VAL 115 116 116 VAL VAL A . n 
A 1 116 GLU 116 117 117 GLU GLU A . n 
A 1 117 MET 117 118 118 MET MET A . n 
A 1 118 LEU 118 119 119 LEU LEU A . n 
A 1 119 SER 119 120 120 SER SER A . n 
A 1 120 GLU 120 121 121 GLU GLU A . n 
A 1 121 GLU 121 122 122 GLU GLU A . n 
A 1 122 ILE 122 123 123 ILE ILE A . n 
A 1 123 ALA 123 124 124 ALA ALA A . n 
A 1 124 ARG 124 125 125 ARG ARG A . n 
A 1 125 THR 125 126 126 THR THR A . n 
A 1 126 TYR 126 127 127 TYR TYR A . n 
A 1 127 ARG 127 128 128 ARG ARG A . n 
A 1 128 VAL 128 129 129 VAL VAL A . n 
A 1 129 GLU 129 130 130 GLU GLU A . n 
A 1 130 ASP 130 131 131 ASP ASP A . n 
A 1 131 HIS 131 132 132 HIS HIS A . n 
A 1 132 TYR 132 133 133 TYR TYR A . n 
A 1 133 GLY 133 134 134 GLY GLY A . n 
A 1 134 THR 134 135 135 THR THR A . n 
A 1 135 ARG 135 136 136 ARG ARG A . n 
A 1 136 LEU 136 137 137 LEU LEU A . n 
A 1 137 GLU 137 138 138 GLU GLU A . n 
A 1 138 GLU 138 139 139 GLU GLU A . n 
A 1 139 HIS 139 140 140 HIS HIS A . n 
A 1 140 THR 140 141 141 THR THR A . n 
A 1 141 TYR 141 142 142 TYR TYR A . n 
A 1 142 LEU 142 143 143 LEU LEU A . n 
A 1 143 GLY 143 144 144 GLY GLY A . n 
A 1 144 THR 144 145 145 THR THR A . n 
A 1 145 THR 145 146 146 THR THR A . n 
A 1 146 PRO 146 147 147 PRO PRO A . n 
A 1 147 ASN 147 148 148 ASN ASN A . n 
A 1 148 GLY 148 149 149 GLY GLY A . n 
A 1 149 VAL 149 150 150 VAL VAL A . n 
A 1 150 PRO 150 151 151 PRO PRO A . n 
A 1 151 ALA 151 152 152 ALA ALA A . n 
A 1 152 TRP 152 153 153 TRP TRP A . n 
A 1 153 ILE 153 154 154 ILE ILE A . n 
A 1 154 ASP 154 155 155 ASP ASP A . n 
A 1 155 SER 155 156 156 SER SER A . n 
A 1 156 ARG 156 157 157 ARG ARG A . n 
A 1 157 TYR 157 158 158 TYR TYR A . n 
A 1 158 VAL 158 159 159 VAL VAL A . n 
A 1 159 GLN 159 160 160 GLN GLN A . n 
A 1 160 ALA 160 161 161 ALA ALA A . n 
A 1 161 ASP 161 162 162 ASP ASP A . n 
A 1 162 LEU 162 163 163 LEU LEU A . n 
A 1 163 LYS 163 164 164 LYS LYS A . n 
A 1 164 ILE 164 165 165 ILE ILE A . n 
A 1 165 ALA 165 166 166 ALA ALA A . n 
A 1 166 THR 166 167 167 THR THR A . n 
A 1 167 GLY 167 168 168 GLY GLY A . n 
A 1 168 LEU 168 169 169 LEU LEU A . n 
A 1 169 ILE 169 170 170 ILE ILE A . n 
A 1 170 GLU 170 171 171 GLU GLU A . n 
A 1 171 PRO 171 172 172 PRO PRO A . n 
A 1 172 HIS 172 173 173 HIS HIS A . n 
A 1 173 LEU 173 174 174 LEU LEU A . n 
A 1 174 MET 174 175 175 MET MET A . n 
A 1 175 ALA 175 176 176 ALA ALA A . n 
A 1 176 GLY 176 177 177 GLY GLY A . n 
A 1 177 TYR 177 178 178 TYR TYR A . n 
A 1 178 SER 178 179 179 SER SER A . n 
A 1 179 GLY 179 180 180 GLY GLY A . n 
A 1 180 GLY 180 181 181 GLY GLY A . n 
A 1 181 ARG 181 182 182 ARG ARG A . n 
A 1 182 LYS 182 183 183 LYS LYS A . n 
A 1 183 LEU 183 184 184 LEU LEU A . n 
A 1 184 ILE 184 185 185 ILE ILE A . n 
A 1 185 CYS 185 186 186 CYS CYS A . n 
A 1 186 PRO 186 187 187 PRO PRO A . n 
A 1 187 GLY 187 188 188 GLY GLY A . n 
A 1 188 ILE 188 189 189 ILE ILE A . n 
A 1 189 ALA 189 190 190 ALA ALA A . n 
A 1 190 ALA 190 191 191 ALA ALA A . n 
A 1 191 PHE 191 192 192 PHE PHE A . n 
A 1 192 GLU 192 193 193 GLU GLU A . n 
A 1 193 THR 193 194 194 THR THR A . n 
A 1 194 VAL 194 195 195 VAL VAL A . n 
A 1 195 LYS 195 196 196 LYS LYS A . n 
A 1 196 LEU 196 197 197 LEU LEU A . n 
A 1 197 TRP 197 198 198 TRP TRP A . n 
A 1 198 HIS 198 199 199 HIS HIS A . n 
A 1 199 GLY 199 200 200 GLY GLY A . n 
A 1 200 PRO 200 201 201 PRO PRO A . n 
A 1 201 ARG 201 202 202 ARG ARG A . n 
A 1 202 PHE 202 203 203 PHE PHE A . n 
A 1 203 LEU 203 204 204 LEU LEU A . n 
A 1 204 GLU 204 205 205 GLU GLU A . n 
A 1 205 HIS 205 206 206 HIS HIS A . n 
A 1 206 PRO 206 207 207 PRO PRO A . n 
A 1 207 LEU 207 208 208 LEU LEU A . n 
A 1 208 ALA 208 209 209 ALA ALA A . n 
A 1 209 ASP 209 210 210 ASP ASP A . n 
A 1 210 CYS 210 211 211 CYS CYS A . n 
A 1 211 GLY 211 212 212 GLY GLY A . n 
A 1 212 PHE 212 213 213 PHE PHE A . n 
A 1 213 LEU 213 214 214 LEU LEU A . n 
A 1 214 GLU 214 215 215 GLU GLU A . n 
A 1 215 GLY 215 216 216 GLY GLY A . n 
A 1 216 ASN 216 217 217 ASN ASN A . n 
A 1 217 PRO 217 218 218 PRO PRO A . n 
A 1 218 VAL 218 219 219 VAL VAL A . n 
A 1 219 HIS 219 220 220 HIS HIS A . n 
A 1 220 GLU 220 221 221 GLU GLU A . n 
A 1 221 GLU 221 222 222 GLU GLU A . n 
A 1 222 ASN 222 223 223 ASN ASN A . n 
A 1 223 THR 223 224 224 THR THR A . n 
A 1 224 ARG 224 225 225 ARG ARG A . n 
A 1 225 ILE 225 226 226 ILE ILE A . n 
A 1 226 ALA 226 227 227 ALA ALA A . n 
A 1 227 ARG 227 228 228 ARG ARG A . n 
A 1 228 MET 228 229 229 MET MET A . n 
A 1 229 ALA 229 230 230 ALA ALA A . n 
A 1 230 GLY 230 231 231 GLY GLY A . n 
A 1 231 CYS 231 232 232 CYS CYS A . n 
A 1 232 ASP 232 233 233 ASP ASP A . n 
A 1 233 PHE 233 234 234 PHE PHE A . n 
A 1 234 ILE 234 235 235 ILE ILE A . n 
A 1 235 VAL 235 236 236 VAL VAL A . n 
A 1 236 ASN 236 237 237 ASN ASN A . n 
A 1 237 VAL 237 238 238 VAL VAL A . n 
A 1 238 THR 238 239 239 THR THR A . n 
A 1 239 LEU 239 240 240 LEU LEU A . n 
A 1 240 ASP 240 241 241 ASP ASP A . n 
A 1 241 GLY 241 242 242 GLY GLY A . n 
A 1 242 ALA 242 243 243 ALA ALA A . n 
A 1 243 ARG 243 244 244 ARG ARG A . n 
A 1 244 ARG 244 245 245 ARG ARG A . n 
A 1 245 ILE 245 246 246 ILE ILE A . n 
A 1 246 THR 246 247 247 THR THR A . n 
A 1 247 SER 247 248 248 SER SER A . n 
A 1 248 VAL 248 249 249 VAL VAL A . n 
A 1 249 VAL 249 250 250 VAL VAL A . n 
A 1 250 ALA 250 251 251 ALA ALA A . n 
A 1 251 GLY 251 252 252 GLY GLY A . n 
A 1 252 ASP 252 253 253 ASP ASP A . n 
A 1 253 MET 253 254 254 MET MET A . n 
A 1 254 GLU 254 255 255 GLU GLU A . n 
A 1 255 GLN 255 256 256 GLN GLN A . n 
A 1 256 ALA 256 257 257 ALA ALA A . n 
A 1 257 PHE 257 258 258 PHE PHE A . n 
A 1 258 LEU 258 259 259 LEU LEU A . n 
A 1 259 LYS 259 260 260 LYS LYS A . n 
A 1 260 GLY 260 261 261 GLY GLY A . n 
A 1 261 VAL 261 262 262 VAL VAL A . n 
A 1 262 ALA 262 263 263 ALA ALA A . n 
A 1 263 PHE 263 264 264 PHE PHE A . n 
A 1 264 VAL 264 265 265 VAL VAL A . n 
A 1 265 GLU 265 266 266 GLU GLU A . n 
A 1 266 THR 266 267 267 THR THR A . n 
A 1 267 VAL 267 268 268 VAL VAL A . n 
A 1 268 VAL 268 269 269 VAL VAL A . n 
A 1 269 LYS 269 270 270 LYS LYS A . n 
A 1 270 ALA 270 271 271 ALA ALA A . n 
A 1 271 ALA 271 272 272 ALA ALA A . n 
A 1 272 VAL 272 273 273 VAL VAL A . n 
A 1 273 PRO 273 274 274 PRO PRO A . n 
A 1 274 ALA 274 275 275 ALA ALA A . n 
A 1 275 PRO 275 276 276 PRO PRO A . n 
A 1 276 VAL 276 277 277 VAL VAL A . n 
A 1 277 ASP 277 278 278 ASP ASP A . n 
A 1 278 VAL 278 279 279 VAL VAL A . n 
A 1 279 VAL 279 280 280 VAL VAL A . n 
A 1 280 VAL 280 281 281 VAL VAL A . n 
A 1 281 THR 281 282 282 THR THR A . n 
A 1 282 SER 282 283 283 SER SER A . n 
A 1 283 SER 283 284 284 SER SER A . n 
A 1 284 ALA 284 285 285 ALA ALA A . n 
A 1 285 GLY 285 286 286 GLY GLY A . n 
A 1 286 HIS 286 287 287 HIS HIS A . n 
A 1 287 PRO 287 288 288 PRO PRO A . n 
A 1 288 LEU 288 289 289 LEU LEU A . n 
A 1 289 ASP 289 290 290 ASP ASP A . n 
A 1 290 LEU 290 291 291 LEU LEU A . n 
A 1 291 THR 291 292 292 THR THR A . n 
A 1 292 PHE 292 293 293 PHE PHE A . n 
A 1 293 TYR 293 294 294 TYR TYR A . n 
A 1 294 GLN 294 295 295 GLN GLN A . n 
A 1 295 ALA 295 296 296 ALA ALA A . n 
A 1 296 VAL 296 297 297 VAL VAL A . n 
A 1 297 LYS 297 298 298 LYS LYS A . n 
A 1 298 GLY 298 299 299 GLY GLY A . n 
A 1 299 LEU 299 300 300 LEU LEU A . n 
A 1 300 THR 300 301 301 THR THR A . n 
A 1 301 GLY 301 302 302 GLY GLY A . n 
A 1 302 ALA 302 303 303 ALA ALA A . n 
A 1 303 LEU 303 304 304 LEU LEU A . n 
A 1 304 PRO 304 305 305 PRO PRO A . n 
A 1 305 ILE 305 306 306 ILE ILE A . n 
A 1 306 VAL 306 307 307 VAL VAL A . n 
A 1 307 LYS 307 308 308 LYS LYS A . n 
A 1 308 PRO 308 309 309 PRO PRO A . n 
A 1 309 GLY 309 310 310 GLY GLY A . n 
A 1 310 GLY 310 311 311 GLY GLY A . n 
A 1 311 THR 311 312 312 THR THR A . n 
A 1 312 ILE 312 313 313 ILE ILE A . n 
A 1 313 VAL 313 314 314 VAL VAL A . n 
A 1 314 ILE 314 315 315 ILE ILE A . n 
A 1 315 ALA 315 316 316 ALA ALA A . n 
A 1 316 ALA 316 317 317 ALA ALA A . n 
A 1 317 ALA 317 318 318 ALA ALA A . n 
A 1 318 LEU 318 319 319 LEU LEU A . n 
A 1 319 ALA 319 320 320 ALA ALA A . n 
A 1 320 GLU 320 321 321 GLU GLU A . n 
A 1 321 GLY 321 322 322 GLY GLY A . n 
A 1 322 LEU 322 323 323 LEU LEU A . n 
A 1 323 GLY 323 324 324 GLY GLY A . n 
A 1 324 SER 324 325 325 SER SER A . n 
A 1 325 PRO 325 326 326 PRO PRO A . n 
A 1 326 GLU 326 327 327 GLU GLU A . n 
A 1 327 PHE 327 328 328 PHE PHE A . n 
A 1 328 GLN 328 329 329 GLN GLN A . n 
A 1 329 SER 329 330 330 SER SER A . n 
A 1 330 LEU 330 331 331 LEU LEU A . n 
A 1 331 PHE 331 332 332 PHE PHE A . n 
A 1 332 GLU 332 333 333 GLU GLU A . n 
A 1 333 GLU 333 334 334 GLU GLU A . n 
A 1 334 HIS 334 335 335 HIS HIS A . n 
A 1 335 PRO 335 336 336 PRO PRO A . n 
A 1 336 THR 336 337 337 THR THR A . n 
A 1 337 LEU 337 338 338 LEU LEU A . n 
A 1 338 GLU 338 339 339 GLU GLU A . n 
A 1 339 GLY 339 340 340 GLY GLY A . n 
A 1 340 PHE 340 341 341 PHE PHE A . n 
A 1 341 MET 341 342 342 MET MET A . n 
A 1 342 GLU 342 343 343 GLU GLU A . n 
A 1 343 ALA 343 344 344 ALA ALA A . n 
A 1 344 ILE 344 345 345 ILE ILE A . n 
A 1 345 LEU 345 346 346 LEU LEU A . n 
A 1 346 LYS 346 347 347 LYS LYS A . n 
A 1 347 GLU 347 348 348 GLU GLU A . n 
A 1 348 GLU 348 349 349 GLU GLU A . n 
A 1 349 SER 349 350 350 SER SER A . n 
A 1 350 PHE 350 351 351 PHE PHE A . n 
A 1 351 THR 351 352 352 THR THR A . n 
A 1 352 VAL 352 353 353 VAL VAL A . n 
A 1 353 ASP 353 354 354 ASP ASP A . n 
A 1 354 GLN 354 355 355 GLN GLN A . n 
A 1 355 TRP 355 356 356 TRP TRP A . n 
A 1 356 GLN 356 357 357 GLN GLN A . n 
A 1 357 LEU 357 358 358 LEU LEU A . n 
A 1 358 GLU 358 359 359 GLU GLU A . n 
A 1 359 GLU 359 360 360 GLU GLU A . n 
A 1 360 LEU 360 361 361 LEU LEU A . n 
A 1 361 ALA 361 362 362 ALA ALA A . n 
A 1 362 LYS 362 363 363 LYS LYS A . n 
A 1 363 VAL 363 364 364 VAL VAL A . n 
A 1 364 ARG 364 365 365 ARG ARG A . n 
A 1 365 ARG 365 366 366 ARG ARG A . n 
A 1 366 LYS 366 367 367 LYS LYS A . n 
A 1 367 ALA 367 368 368 ALA ALA A . n 
A 1 368 ARG 368 369 369 ARG ARG A . n 
A 1 369 VAL 369 370 370 VAL VAL A . n 
A 1 370 LYS 370 371 371 LYS LYS A . n 
A 1 371 PHE 371 372 372 PHE PHE A . n 
A 1 372 VAL 372 373 373 VAL VAL A . n 
A 1 373 SER 373 374 374 SER SER A . n 
A 1 374 ASP 374 375 375 ASP ASP A . n 
A 1 375 GLY 375 376 376 GLY GLY A . n 
A 1 376 VAL 376 377 377 VAL VAL A . n 
A 1 377 PRO 377 378 378 PRO PRO A . n 
A 1 378 ALA 378 379 379 ALA ALA A . n 
A 1 379 ALA 379 380 380 ALA ALA A . n 
A 1 380 VAL 380 381 381 VAL VAL A . n 
A 1 381 LEU 381 382 382 LEU LEU A . n 
A 1 382 SER 382 383 383 SER SER A . n 
A 1 383 ARG 383 384 384 ARG ARG A . n 
A 1 384 CYS 384 385 385 CYS CYS A . n 
A 1 385 HIS 385 386 386 HIS HIS A . n 
A 1 386 VAL 386 387 387 VAL VAL A . n 
A 1 387 GLU 387 388 388 GLU GLU A . n 
A 1 388 PRO 388 389 389 PRO PRO A . n 
A 1 389 VAL 389 390 390 VAL VAL A . n 
A 1 390 ALA 390 391 391 ALA ALA A . n 
A 1 391 THR 391 392 392 THR THR A . n 
A 1 392 VAL 392 393 393 VAL VAL A . n 
A 1 393 GLU 393 394 394 GLU GLU A . n 
A 1 394 LEU 394 395 395 LEU LEU A . n 
A 1 395 ALA 395 396 396 ALA ALA A . n 
A 1 396 VAL 396 397 397 VAL VAL A . n 
A 1 397 ALA 397 398 398 ALA ALA A . n 
A 1 398 GLN 398 399 399 GLN GLN A . n 
A 1 399 ALA 399 400 400 ALA ALA A . n 
A 1 400 LEU 400 401 401 LEU LEU A . n 
A 1 401 GLU 401 402 402 GLU GLU A . n 
A 1 402 GLN 402 403 403 GLN GLN A . n 
A 1 403 TYR 403 404 404 TYR TYR A . n 
A 1 404 GLY 404 405 405 GLY GLY A . n 
A 1 405 PRO 405 406 406 PRO PRO A . n 
A 1 406 GLU 406 407 407 GLU GLU A . n 
A 1 407 ALA 407 408 408 ALA ALA A . n 
A 1 408 ARG 408 409 409 ARG ARG A . n 
A 1 409 VAL 409 410 410 VAL VAL A . n 
A 1 410 ALA 410 411 411 ALA ALA A . n 
A 1 411 VAL 411 412 412 VAL VAL A . n 
A 1 412 ILE 412 413 413 ILE ILE A . n 
A 1 413 PRO 413 414 414 PRO PRO A . n 
A 1 414 LYS 414 415 415 LYS LYS A . n 
A 1 415 GLY 415 416 416 GLY GLY A . n 
A 1 416 PRO 416 417 417 PRO PRO A . n 
A 1 417 TYR 417 418 418 TYR TYR A . n 
A 1 418 VAL 418 419 419 VAL VAL A . n 
A 1 419 LEU 419 420 420 LEU LEU A . n 
A 1 420 PRO 420 421 421 PRO PRO A . n 
A 1 421 VAL 421 422 422 VAL VAL A . n 
A 1 422 VAL 422 423 423 VAL VAL A . n 
A 1 423 ASP 423 424 424 ASP ASP A . n 
A 1 424 PRO 424 425 425 PRO PRO A . n 
A 1 425 THR 425 426 426 THR THR A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 4EY ? ? 4EY ? ? 'SUBJECT OF INVESTIGATION' ? 
2 UCU ? ? UCU ? ? 'SUBJECT OF INVESTIGATION' ? 
3 NI  ? ? NI  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UCU 1   501  503 UCU D2H A . 
C 3 4EY 1   502  504 4EY 4EY A . 
D 4 NI  1   503  3   NI  NI  A . 
E 5 PO4 1   504  1   PO4 PO4 A . 
F 5 PO4 1   505  2   PO4 PO4 A . 
G 6 HOH 1   601  421 HOH HOH A . 
G 6 HOH 2   602  665 HOH HOH A . 
G 6 HOH 3   603  533 HOH HOH A . 
G 6 HOH 4   604  445 HOH HOH A . 
G 6 HOH 5   605  405 HOH HOH A . 
G 6 HOH 6   606  311 HOH HOH A . 
G 6 HOH 7   607  62  HOH HOH A . 
G 6 HOH 8   608  412 HOH HOH A . 
G 6 HOH 9   609  686 HOH HOH A . 
G 6 HOH 10  610  692 HOH HOH A . 
G 6 HOH 11  611  259 HOH HOH A . 
G 6 HOH 12  612  300 HOH HOH A . 
G 6 HOH 13  613  4   HOH HOH A . 
G 6 HOH 14  614  212 HOH HOH A . 
G 6 HOH 15  615  101 HOH HOH A . 
G 6 HOH 16  616  388 HOH HOH A . 
G 6 HOH 17  617  75  HOH HOH A . 
G 6 HOH 18  618  184 HOH HOH A . 
G 6 HOH 19  619  235 HOH HOH A . 
G 6 HOH 20  620  223 HOH HOH A . 
G 6 HOH 21  621  248 HOH HOH A . 
G 6 HOH 22  622  163 HOH HOH A . 
G 6 HOH 23  623  451 HOH HOH A . 
G 6 HOH 24  624  243 HOH HOH A . 
G 6 HOH 25  625  236 HOH HOH A . 
G 6 HOH 26  626  56  HOH HOH A . 
G 6 HOH 27  627  139 HOH HOH A . 
G 6 HOH 28  628  389 HOH HOH A . 
G 6 HOH 29  629  230 HOH HOH A . 
G 6 HOH 30  630  50  HOH HOH A . 
G 6 HOH 31  631  400 HOH HOH A . 
G 6 HOH 32  632  54  HOH HOH A . 
G 6 HOH 33  633  430 HOH HOH A . 
G 6 HOH 34  634  297 HOH HOH A . 
G 6 HOH 35  635  392 HOH HOH A . 
G 6 HOH 36  636  398 HOH HOH A . 
G 6 HOH 37  637  237 HOH HOH A . 
G 6 HOH 38  638  245 HOH HOH A . 
G 6 HOH 39  639  29  HOH HOH A . 
G 6 HOH 40  640  105 HOH HOH A . 
G 6 HOH 41  641  288 HOH HOH A . 
G 6 HOH 42  642  335 HOH HOH A . 
G 6 HOH 43  643  422 HOH HOH A . 
G 6 HOH 44  644  114 HOH HOH A . 
G 6 HOH 45  645  33  HOH HOH A . 
G 6 HOH 46  646  276 HOH HOH A . 
G 6 HOH 47  647  691 HOH HOH A . 
G 6 HOH 48  648  299 HOH HOH A . 
G 6 HOH 49  649  127 HOH HOH A . 
G 6 HOH 50  650  154 HOH HOH A . 
G 6 HOH 51  651  195 HOH HOH A . 
G 6 HOH 52  652  254 HOH HOH A . 
G 6 HOH 53  653  186 HOH HOH A . 
G 6 HOH 54  654  188 HOH HOH A . 
G 6 HOH 55  655  206 HOH HOH A . 
G 6 HOH 56  656  111 HOH HOH A . 
G 6 HOH 57  657  94  HOH HOH A . 
G 6 HOH 58  658  59  HOH HOH A . 
G 6 HOH 59  659  229 HOH HOH A . 
G 6 HOH 60  660  417 HOH HOH A . 
G 6 HOH 61  661  64  HOH HOH A . 
G 6 HOH 62  662  121 HOH HOH A . 
G 6 HOH 63  663  34  HOH HOH A . 
G 6 HOH 64  664  409 HOH HOH A . 
G 6 HOH 65  665  447 HOH HOH A . 
G 6 HOH 66  666  145 HOH HOH A . 
G 6 HOH 67  667  164 HOH HOH A . 
G 6 HOH 68  668  673 HOH HOH A . 
G 6 HOH 69  669  399 HOH HOH A . 
G 6 HOH 70  670  253 HOH HOH A . 
G 6 HOH 71  671  279 HOH HOH A . 
G 6 HOH 72  672  123 HOH HOH A . 
G 6 HOH 73  673  304 HOH HOH A . 
G 6 HOH 74  674  356 HOH HOH A . 
G 6 HOH 75  675  43  HOH HOH A . 
G 6 HOH 76  676  426 HOH HOH A . 
G 6 HOH 77  677  672 HOH HOH A . 
G 6 HOH 78  678  419 HOH HOH A . 
G 6 HOH 79  679  92  HOH HOH A . 
G 6 HOH 80  680  207 HOH HOH A . 
G 6 HOH 81  681  39  HOH HOH A . 
G 6 HOH 82  682  17  HOH HOH A . 
G 6 HOH 83  683  338 HOH HOH A . 
G 6 HOH 84  684  323 HOH HOH A . 
G 6 HOH 85  685  93  HOH HOH A . 
G 6 HOH 86  686  91  HOH HOH A . 
G 6 HOH 87  687  159 HOH HOH A . 
G 6 HOH 88  688  84  HOH HOH A . 
G 6 HOH 89  689  217 HOH HOH A . 
G 6 HOH 90  690  397 HOH HOH A . 
G 6 HOH 91  691  71  HOH HOH A . 
G 6 HOH 92  692  316 HOH HOH A . 
G 6 HOH 93  693  7   HOH HOH A . 
G 6 HOH 94  694  10  HOH HOH A . 
G 6 HOH 95  695  30  HOH HOH A . 
G 6 HOH 96  696  391 HOH HOH A . 
G 6 HOH 97  697  81  HOH HOH A . 
G 6 HOH 98  698  189 HOH HOH A . 
G 6 HOH 99  699  97  HOH HOH A . 
G 6 HOH 100 700  414 HOH HOH A . 
G 6 HOH 101 701  171 HOH HOH A . 
G 6 HOH 102 702  192 HOH HOH A . 
G 6 HOH 103 703  290 HOH HOH A . 
G 6 HOH 104 704  383 HOH HOH A . 
G 6 HOH 105 705  115 HOH HOH A . 
G 6 HOH 106 706  650 HOH HOH A . 
G 6 HOH 107 707  224 HOH HOH A . 
G 6 HOH 108 708  191 HOH HOH A . 
G 6 HOH 109 709  178 HOH HOH A . 
G 6 HOH 110 710  355 HOH HOH A . 
G 6 HOH 111 711  21  HOH HOH A . 
G 6 HOH 112 712  257 HOH HOH A . 
G 6 HOH 113 713  256 HOH HOH A . 
G 6 HOH 114 714  16  HOH HOH A . 
G 6 HOH 115 715  208 HOH HOH A . 
G 6 HOH 116 716  176 HOH HOH A . 
G 6 HOH 117 717  702 HOH HOH A . 
G 6 HOH 118 718  174 HOH HOH A . 
G 6 HOH 119 719  352 HOH HOH A . 
G 6 HOH 120 720  384 HOH HOH A . 
G 6 HOH 121 721  386 HOH HOH A . 
G 6 HOH 122 722  209 HOH HOH A . 
G 6 HOH 123 723  226 HOH HOH A . 
G 6 HOH 124 724  133 HOH HOH A . 
G 6 HOH 125 725  147 HOH HOH A . 
G 6 HOH 126 726  380 HOH HOH A . 
G 6 HOH 127 727  3   HOH HOH A . 
G 6 HOH 128 728  80  HOH HOH A . 
G 6 HOH 129 729  196 HOH HOH A . 
G 6 HOH 130 730  9   HOH HOH A . 
G 6 HOH 131 731  106 HOH HOH A . 
G 6 HOH 132 732  267 HOH HOH A . 
G 6 HOH 133 733  78  HOH HOH A . 
G 6 HOH 134 734  427 HOH HOH A . 
G 6 HOH 135 735  65  HOH HOH A . 
G 6 HOH 136 736  390 HOH HOH A . 
G 6 HOH 137 737  202 HOH HOH A . 
G 6 HOH 138 738  128 HOH HOH A . 
G 6 HOH 139 739  168 HOH HOH A . 
G 6 HOH 140 740  331 HOH HOH A . 
G 6 HOH 141 741  165 HOH HOH A . 
G 6 HOH 142 742  264 HOH HOH A . 
G 6 HOH 143 743  132 HOH HOH A . 
G 6 HOH 144 744  172 HOH HOH A . 
G 6 HOH 145 745  6   HOH HOH A . 
G 6 HOH 146 746  74  HOH HOH A . 
G 6 HOH 147 747  15  HOH HOH A . 
G 6 HOH 148 748  49  HOH HOH A . 
G 6 HOH 149 749  401 HOH HOH A . 
G 6 HOH 150 750  98  HOH HOH A . 
G 6 HOH 151 751  627 HOH HOH A . 
G 6 HOH 152 752  40  HOH HOH A . 
G 6 HOH 153 753  152 HOH HOH A . 
G 6 HOH 154 754  418 HOH HOH A . 
G 6 HOH 155 755  120 HOH HOH A . 
G 6 HOH 156 756  35  HOH HOH A . 
G 6 HOH 157 757  173 HOH HOH A . 
G 6 HOH 158 758  410 HOH HOH A . 
G 6 HOH 159 759  26  HOH HOH A . 
G 6 HOH 160 760  181 HOH HOH A . 
G 6 HOH 161 761  219 HOH HOH A . 
G 6 HOH 162 762  8   HOH HOH A . 
G 6 HOH 163 763  696 HOH HOH A . 
G 6 HOH 164 764  144 HOH HOH A . 
G 6 HOH 165 765  129 HOH HOH A . 
G 6 HOH 166 766  136 HOH HOH A . 
G 6 HOH 167 767  199 HOH HOH A . 
G 6 HOH 168 768  103 HOH HOH A . 
G 6 HOH 169 769  201 HOH HOH A . 
G 6 HOH 170 770  146 HOH HOH A . 
G 6 HOH 171 771  134 HOH HOH A . 
G 6 HOH 172 772  770 HOH HOH A . 
G 6 HOH 173 773  143 HOH HOH A . 
G 6 HOH 174 774  353 HOH HOH A . 
G 6 HOH 175 775  675 HOH HOH A . 
G 6 HOH 176 776  317 HOH HOH A . 
G 6 HOH 177 777  310 HOH HOH A . 
G 6 HOH 178 778  395 HOH HOH A . 
G 6 HOH 179 779  694 HOH HOH A . 
G 6 HOH 180 780  104 HOH HOH A . 
G 6 HOH 181 781  678 HOH HOH A . 
G 6 HOH 182 782  47  HOH HOH A . 
G 6 HOH 183 783  112 HOH HOH A . 
G 6 HOH 184 784  175 HOH HOH A . 
G 6 HOH 185 785  44  HOH HOH A . 
G 6 HOH 186 786  268 HOH HOH A . 
G 6 HOH 187 787  58  HOH HOH A . 
G 6 HOH 188 788  364 HOH HOH A . 
G 6 HOH 189 789  359 HOH HOH A . 
G 6 HOH 190 790  408 HOH HOH A . 
G 6 HOH 191 791  45  HOH HOH A . 
G 6 HOH 192 792  46  HOH HOH A . 
G 6 HOH 193 793  411 HOH HOH A . 
G 6 HOH 194 794  703 HOH HOH A . 
G 6 HOH 195 795  334 HOH HOH A . 
G 6 HOH 196 796  177 HOH HOH A . 
G 6 HOH 197 797  86  HOH HOH A . 
G 6 HOH 198 798  83  HOH HOH A . 
G 6 HOH 199 799  79  HOH HOH A . 
G 6 HOH 200 800  130 HOH HOH A . 
G 6 HOH 201 801  225 HOH HOH A . 
G 6 HOH 202 802  190 HOH HOH A . 
G 6 HOH 203 803  22  HOH HOH A . 
G 6 HOH 204 804  796 HOH HOH A . 
G 6 HOH 205 805  12  HOH HOH A . 
G 6 HOH 206 806  72  HOH HOH A . 
G 6 HOH 207 807  262 HOH HOH A . 
G 6 HOH 208 808  31  HOH HOH A . 
G 6 HOH 209 809  289 HOH HOH A . 
G 6 HOH 210 810  660 HOH HOH A . 
G 6 HOH 211 811  42  HOH HOH A . 
G 6 HOH 212 812  102 HOH HOH A . 
G 6 HOH 213 813  679 HOH HOH A . 
G 6 HOH 214 814  793 HOH HOH A . 
G 6 HOH 215 815  222 HOH HOH A . 
G 6 HOH 216 816  149 HOH HOH A . 
G 6 HOH 217 817  66  HOH HOH A . 
G 6 HOH 218 818  53  HOH HOH A . 
G 6 HOH 219 819  420 HOH HOH A . 
G 6 HOH 220 820  180 HOH HOH A . 
G 6 HOH 221 821  324 HOH HOH A . 
G 6 HOH 222 822  25  HOH HOH A . 
G 6 HOH 223 823  218 HOH HOH A . 
G 6 HOH 224 824  70  HOH HOH A . 
G 6 HOH 225 825  249 HOH HOH A . 
G 6 HOH 226 826  100 HOH HOH A . 
G 6 HOH 227 827  126 HOH HOH A . 
G 6 HOH 228 828  258 HOH HOH A . 
G 6 HOH 229 829  200 HOH HOH A . 
G 6 HOH 230 830  109 HOH HOH A . 
G 6 HOH 231 831  244 HOH HOH A . 
G 6 HOH 232 832  108 HOH HOH A . 
G 6 HOH 233 833  63  HOH HOH A . 
G 6 HOH 234 834  211 HOH HOH A . 
G 6 HOH 235 835  381 HOH HOH A . 
G 6 HOH 236 836  38  HOH HOH A . 
G 6 HOH 237 837  402 HOH HOH A . 
G 6 HOH 238 838  251 HOH HOH A . 
G 6 HOH 239 839  37  HOH HOH A . 
G 6 HOH 240 840  396 HOH HOH A . 
G 6 HOH 241 841  294 HOH HOH A . 
G 6 HOH 242 842  771 HOH HOH A . 
G 6 HOH 243 843  441 HOH HOH A . 
G 6 HOH 244 844  250 HOH HOH A . 
G 6 HOH 245 845  113 HOH HOH A . 
G 6 HOH 246 846  117 HOH HOH A . 
G 6 HOH 247 847  413 HOH HOH A . 
G 6 HOH 248 848  140 HOH HOH A . 
G 6 HOH 249 849  32  HOH HOH A . 
G 6 HOH 250 850  99  HOH HOH A . 
G 6 HOH 251 851  135 HOH HOH A . 
G 6 HOH 252 852  261 HOH HOH A . 
G 6 HOH 253 853  52  HOH HOH A . 
G 6 HOH 254 854  157 HOH HOH A . 
G 6 HOH 255 855  215 HOH HOH A . 
G 6 HOH 256 856  351 HOH HOH A . 
G 6 HOH 257 857  337 HOH HOH A . 
G 6 HOH 258 858  349 HOH HOH A . 
G 6 HOH 259 859  319 HOH HOH A . 
G 6 HOH 260 860  158 HOH HOH A . 
G 6 HOH 261 861  272 HOH HOH A . 
G 6 HOH 262 862  11  HOH HOH A . 
G 6 HOH 263 863  116 HOH HOH A . 
G 6 HOH 264 864  270 HOH HOH A . 
G 6 HOH 265 865  238 HOH HOH A . 
G 6 HOH 266 866  88  HOH HOH A . 
G 6 HOH 267 867  141 HOH HOH A . 
G 6 HOH 268 868  363 HOH HOH A . 
G 6 HOH 269 869  166 HOH HOH A . 
G 6 HOH 270 870  67  HOH HOH A . 
G 6 HOH 271 871  23  HOH HOH A . 
G 6 HOH 272 872  377 HOH HOH A . 
G 6 HOH 273 873  677 HOH HOH A . 
G 6 HOH 274 874  41  HOH HOH A . 
G 6 HOH 275 875  95  HOH HOH A . 
G 6 HOH 276 876  197 HOH HOH A . 
G 6 HOH 277 877  131 HOH HOH A . 
G 6 HOH 278 878  695 HOH HOH A . 
G 6 HOH 279 879  274 HOH HOH A . 
G 6 HOH 280 880  148 HOH HOH A . 
G 6 HOH 281 881  210 HOH HOH A . 
G 6 HOH 282 882  150 HOH HOH A . 
G 6 HOH 283 883  458 HOH HOH A . 
G 6 HOH 284 884  73  HOH HOH A . 
G 6 HOH 285 885  167 HOH HOH A . 
G 6 HOH 286 886  269 HOH HOH A . 
G 6 HOH 287 887  423 HOH HOH A . 
G 6 HOH 288 888  138 HOH HOH A . 
G 6 HOH 289 889  313 HOH HOH A . 
G 6 HOH 290 890  13  HOH HOH A . 
G 6 HOH 291 891  233 HOH HOH A . 
G 6 HOH 292 892  221 HOH HOH A . 
G 6 HOH 293 893  20  HOH HOH A . 
G 6 HOH 294 894  170 HOH HOH A . 
G 6 HOH 295 895  403 HOH HOH A . 
G 6 HOH 296 896  76  HOH HOH A . 
G 6 HOH 297 897  36  HOH HOH A . 
G 6 HOH 298 898  155 HOH HOH A . 
G 6 HOH 299 899  125 HOH HOH A . 
G 6 HOH 300 900  240 HOH HOH A . 
G 6 HOH 301 901  406 HOH HOH A . 
G 6 HOH 302 902  283 HOH HOH A . 
G 6 HOH 303 903  142 HOH HOH A . 
G 6 HOH 304 904  57  HOH HOH A . 
G 6 HOH 305 905  213 HOH HOH A . 
G 6 HOH 306 906  314 HOH HOH A . 
G 6 HOH 307 907  263 HOH HOH A . 
G 6 HOH 308 908  51  HOH HOH A . 
G 6 HOH 309 909  387 HOH HOH A . 
G 6 HOH 310 910  266 HOH HOH A . 
G 6 HOH 311 911  788 HOH HOH A . 
G 6 HOH 312 912  19  HOH HOH A . 
G 6 HOH 313 913  429 HOH HOH A . 
G 6 HOH 314 914  161 HOH HOH A . 
G 6 HOH 315 915  292 HOH HOH A . 
G 6 HOH 316 916  234 HOH HOH A . 
G 6 HOH 317 917  68  HOH HOH A . 
G 6 HOH 318 918  407 HOH HOH A . 
G 6 HOH 319 919  89  HOH HOH A . 
G 6 HOH 320 920  151 HOH HOH A . 
G 6 HOH 321 921  61  HOH HOH A . 
G 6 HOH 322 922  794 HOH HOH A . 
G 6 HOH 323 923  693 HOH HOH A . 
G 6 HOH 324 924  346 HOH HOH A . 
G 6 HOH 325 925  362 HOH HOH A . 
G 6 HOH 326 926  321 HOH HOH A . 
G 6 HOH 327 927  428 HOH HOH A . 
G 6 HOH 328 928  295 HOH HOH A . 
G 6 HOH 329 929  14  HOH HOH A . 
G 6 HOH 330 930  204 HOH HOH A . 
G 6 HOH 331 931  688 HOH HOH A . 
G 6 HOH 332 932  307 HOH HOH A . 
G 6 HOH 333 933  69  HOH HOH A . 
G 6 HOH 334 934  18  HOH HOH A . 
G 6 HOH 335 935  664 HOH HOH A . 
G 6 HOH 336 936  470 HOH HOH A . 
G 6 HOH 337 937  85  HOH HOH A . 
G 6 HOH 338 938  443 HOH HOH A . 
G 6 HOH 339 939  385 HOH HOH A . 
G 6 HOH 340 940  5   HOH HOH A . 
G 6 HOH 341 941  630 HOH HOH A . 
G 6 HOH 342 942  227 HOH HOH A . 
G 6 HOH 343 943  169 HOH HOH A . 
G 6 HOH 344 944  277 HOH HOH A . 
G 6 HOH 345 945  55  HOH HOH A . 
G 6 HOH 346 946  90  HOH HOH A . 
G 6 HOH 347 947  242 HOH HOH A . 
G 6 HOH 348 948  689 HOH HOH A . 
G 6 HOH 349 949  449 HOH HOH A . 
G 6 HOH 350 950  648 HOH HOH A . 
G 6 HOH 351 951  376 HOH HOH A . 
G 6 HOH 352 952  119 HOH HOH A . 
G 6 HOH 353 953  382 HOH HOH A . 
G 6 HOH 354 954  330 HOH HOH A . 
G 6 HOH 355 955  394 HOH HOH A . 
G 6 HOH 356 956  674 HOH HOH A . 
G 6 HOH 357 957  107 HOH HOH A . 
G 6 HOH 358 958  246 HOH HOH A . 
G 6 HOH 359 959  82  HOH HOH A . 
G 6 HOH 360 960  453 HOH HOH A . 
G 6 HOH 361 961  325 HOH HOH A . 
G 6 HOH 362 962  789 HOH HOH A . 
G 6 HOH 363 963  1   HOH HOH A . 
G 6 HOH 364 964  309 HOH HOH A . 
G 6 HOH 365 965  739 HOH HOH A . 
G 6 HOH 366 966  350 HOH HOH A . 
G 6 HOH 367 967  646 HOH HOH A . 
G 6 HOH 368 968  360 HOH HOH A . 
G 6 HOH 369 969  367 HOH HOH A . 
G 6 HOH 370 970  366 HOH HOH A . 
G 6 HOH 371 971  730 HOH HOH A . 
G 6 HOH 372 972  305 HOH HOH A . 
G 6 HOH 373 973  255 HOH HOH A . 
G 6 HOH 374 974  345 HOH HOH A . 
G 6 HOH 375 975  2   HOH HOH A . 
G 6 HOH 376 976  733 HOH HOH A . 
G 6 HOH 377 977  303 HOH HOH A . 
G 6 HOH 378 978  336 HOH HOH A . 
G 6 HOH 379 979  416 HOH HOH A . 
G 6 HOH 380 980  287 HOH HOH A . 
G 6 HOH 381 981  626 HOH HOH A . 
G 6 HOH 382 982  777 HOH HOH A . 
G 6 HOH 383 983  604 HOH HOH A . 
G 6 HOH 384 984  122 HOH HOH A . 
G 6 HOH 385 985  655 HOH HOH A . 
G 6 HOH 386 986  746 HOH HOH A . 
G 6 HOH 387 987  670 HOH HOH A . 
G 6 HOH 388 988  625 HOH HOH A . 
G 6 HOH 389 989  183 HOH HOH A . 
G 6 HOH 390 990  137 HOH HOH A . 
G 6 HOH 391 991  320 HOH HOH A . 
G 6 HOH 392 992  96  HOH HOH A . 
G 6 HOH 393 993  239 HOH HOH A . 
G 6 HOH 394 994  182 HOH HOH A . 
G 6 HOH 395 995  87  HOH HOH A . 
G 6 HOH 396 996  798 HOH HOH A . 
G 6 HOH 397 997  339 HOH HOH A . 
G 6 HOH 398 998  220 HOH HOH A . 
G 6 HOH 399 999  343 HOH HOH A . 
G 6 HOH 400 1000 280 HOH HOH A . 
G 6 HOH 401 1001 370 HOH HOH A . 
G 6 HOH 402 1002 732 HOH HOH A . 
G 6 HOH 403 1003 765 HOH HOH A . 
G 6 HOH 404 1004 436 HOH HOH A . 
G 6 HOH 405 1005 653 HOH HOH A . 
G 6 HOH 406 1006 532 HOH HOH A . 
G 6 HOH 407 1007 308 HOH HOH A . 
G 6 HOH 408 1008 110 HOH HOH A . 
G 6 HOH 409 1009 393 HOH HOH A . 
G 6 HOH 410 1010 534 HOH HOH A . 
G 6 HOH 411 1011 358 HOH HOH A . 
G 6 HOH 412 1012 24  HOH HOH A . 
G 6 HOH 413 1013 659 HOH HOH A . 
G 6 HOH 414 1014 656 HOH HOH A . 
G 6 HOH 415 1015 634 HOH HOH A . 
G 6 HOH 416 1016 791 HOH HOH A . 
G 6 HOH 417 1017 241 HOH HOH A . 
G 6 HOH 418 1018 315 HOH HOH A . 
G 6 HOH 419 1019 306 HOH HOH A . 
G 6 HOH 420 1020 361 HOH HOH A . 
G 6 HOH 421 1021 194 HOH HOH A . 
G 6 HOH 422 1022 193 HOH HOH A . 
G 6 HOH 423 1023 284 HOH HOH A . 
G 6 HOH 424 1024 783 HOH HOH A . 
G 6 HOH 425 1025 252 HOH HOH A . 
G 6 HOH 426 1026 479 HOH HOH A . 
G 6 HOH 427 1027 772 HOH HOH A . 
G 6 HOH 428 1028 298 HOH HOH A . 
G 6 HOH 429 1029 27  HOH HOH A . 
G 6 HOH 430 1030 293 HOH HOH A . 
G 6 HOH 431 1031 365 HOH HOH A . 
G 6 HOH 432 1032 529 HOH HOH A . 
G 6 HOH 433 1033 786 HOH HOH A . 
G 6 HOH 434 1034 782 HOH HOH A . 
G 6 HOH 435 1035 749 HOH HOH A . 
G 6 HOH 436 1036 48  HOH HOH A . 
G 6 HOH 437 1037 333 HOH HOH A . 
G 6 HOH 438 1038 799 HOH HOH A . 
G 6 HOH 439 1039 347 HOH HOH A . 
G 6 HOH 440 1040 536 HOH HOH A . 
G 6 HOH 441 1041 231 HOH HOH A . 
G 6 HOH 442 1042 328 HOH HOH A . 
G 6 HOH 443 1043 327 HOH HOH A . 
G 6 HOH 444 1044 282 HOH HOH A . 
G 6 HOH 445 1045 780 HOH HOH A . 
G 6 HOH 446 1046 216 HOH HOH A . 
G 6 HOH 447 1047 374 HOH HOH A . 
G 6 HOH 448 1048 344 HOH HOH A . 
G 6 HOH 449 1049 348 HOH HOH A . 
G 6 HOH 450 1050 535 HOH HOH A . 
G 6 HOH 451 1051 635 HOH HOH A . 
G 6 HOH 452 1052 322 HOH HOH A . 
G 6 HOH 453 1053 623 HOH HOH A . 
G 6 HOH 454 1054 153 HOH HOH A . 
G 6 HOH 455 1055 271 HOH HOH A . 
G 6 HOH 456 1056 779 HOH HOH A . 
G 6 HOH 457 1057 60  HOH HOH A . 
G 6 HOH 458 1058 118 HOH HOH A . 
G 6 HOH 459 1059 301 HOH HOH A . 
G 6 HOH 460 1060 124 HOH HOH A . 
G 6 HOH 461 1061 326 HOH HOH A . 
G 6 HOH 462 1062 531 HOH HOH A . 
G 6 HOH 463 1063 769 HOH HOH A . 
G 6 HOH 464 1064 459 HOH HOH A . 
G 6 HOH 465 1065 654 HOH HOH A . 
G 6 HOH 466 1066 800 HOH HOH A . 
G 6 HOH 467 1067 77  HOH HOH A . 
G 6 HOH 468 1068 341 HOH HOH A . 
G 6 HOH 469 1069 179 HOH HOH A . 
G 6 HOH 470 1070 372 HOH HOH A . 
G 6 HOH 471 1071 275 HOH HOH A . 
G 6 HOH 472 1072 785 HOH HOH A . 
G 6 HOH 473 1073 205 HOH HOH A . 
G 6 HOH 474 1074 759 HOH HOH A . 
G 6 HOH 475 1075 778 HOH HOH A . 
G 6 HOH 476 1076 663 HOH HOH A . 
G 6 HOH 477 1077 601 HOH HOH A . 
G 6 HOH 478 1078 375 HOH HOH A . 
G 6 HOH 479 1079 302 HOH HOH A . 
G 6 HOH 480 1080 743 HOH HOH A . 
G 6 HOH 481 1081 748 HOH HOH A . 
G 6 HOH 482 1082 342 HOH HOH A . 
G 6 HOH 483 1083 291 HOH HOH A . 
G 6 HOH 484 1084 278 HOH HOH A . 
G 6 HOH 485 1085 203 HOH HOH A . 
G 6 HOH 486 1086 354 HOH HOH A . 
G 6 HOH 487 1087 260 HOH HOH A . 
G 6 HOH 488 1088 633 HOH HOH A . 
G 6 HOH 489 1089 651 HOH HOH A . 
G 6 HOH 490 1090 602 HOH HOH A . 
G 6 HOH 491 1091 228 HOH HOH A . 
G 6 HOH 492 1092 312 HOH HOH A . 
G 6 HOH 493 1093 744 HOH HOH A . 
G 6 HOH 494 1094 731 HOH HOH A . 
G 6 HOH 495 1095 745 HOH HOH A . 
G 6 HOH 496 1096 628 HOH HOH A . 
G 6 HOH 497 1097 624 HOH HOH A . 
G 6 HOH 498 1098 773 HOH HOH A . 
G 6 HOH 499 1099 747 HOH HOH A . 
G 6 HOH 500 1100 198 HOH HOH A . 
G 6 HOH 501 1101 802 HOH HOH A . 
G 6 HOH 502 1102 371 HOH HOH A . 
G 6 HOH 503 1103 357 HOH HOH A . 
G 6 HOH 504 1104 296 HOH HOH A . 
G 6 HOH 505 1105 281 HOH HOH A . 
G 6 HOH 506 1106 528 HOH HOH A . 
G 6 HOH 507 1107 265 HOH HOH A . 
G 6 HOH 508 1108 160 HOH HOH A . 
G 6 HOH 509 1109 632 HOH HOH A . 
G 6 HOH 510 1110 329 HOH HOH A . 
G 6 HOH 511 1111 751 HOH HOH A . 
G 6 HOH 512 1112 332 HOH HOH A . 
G 6 HOH 513 1113 214 HOH HOH A . 
G 6 HOH 514 1114 340 HOH HOH A . 
G 6 HOH 515 1115 801 HOH HOH A . 
G 6 HOH 516 1116 735 HOH HOH A . 
G 6 HOH 517 1117 767 HOH HOH A . 
G 6 HOH 518 1118 797 HOH HOH A . 
G 6 HOH 519 1119 185 HOH HOH A . 
G 6 HOH 520 1120 369 HOH HOH A . 
G 6 HOH 521 1121 639 HOH HOH A . 
G 6 HOH 522 1122 774 HOH HOH A . 
G 6 HOH 523 1123 433 HOH HOH A . 
G 6 HOH 524 1124 600 HOH HOH A . 
G 6 HOH 525 1125 776 HOH HOH A . 
G 6 HOH 526 1126 432 HOH HOH A . 
G 6 HOH 527 1127 756 HOH HOH A . 
G 6 HOH 528 1128 795 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 29  ? NE  ? A ARG 28  NE  
2  1 Y 1 A ARG 29  ? CZ  ? A ARG 28  CZ  
3  1 Y 1 A ARG 29  ? NH1 ? A ARG 28  NH1 
4  1 Y 1 A ARG 29  ? NH2 ? A ARG 28  NH2 
5  1 Y 1 A ARG 62  ? CG  ? A ARG 61  CG  
6  1 Y 1 A ARG 62  ? CD  ? A ARG 61  CD  
7  1 Y 1 A ARG 62  ? NE  ? A ARG 61  NE  
8  1 Y 1 A ARG 62  ? CZ  ? A ARG 61  CZ  
9  1 Y 1 A ARG 62  ? NH1 ? A ARG 61  NH1 
10 1 Y 1 A ARG 62  ? NH2 ? A ARG 61  NH2 
11 1 Y 1 A LYS 347 ? CD  ? A LYS 346 CD  
12 1 Y 1 A LYS 347 ? CE  ? A LYS 346 CE  
13 1 Y 1 A LYS 347 ? NZ  ? A LYS 346 NZ  
14 1 Y 1 A GLU 348 ? CG  ? A GLU 347 CG  
15 1 Y 1 A GLU 348 ? CD  ? A GLU 347 CD  
16 1 Y 1 A GLU 348 ? OE1 ? A GLU 347 OE1 
17 1 Y 1 A GLU 348 ? OE2 ? A GLU 347 OE2 
18 1 Y 1 A GLU 349 ? CG  ? A GLU 348 CG  
19 1 Y 1 A GLU 349 ? CD  ? A GLU 348 CD  
20 1 Y 1 A GLU 349 ? OE1 ? A GLU 348 OE1 
21 1 Y 1 A GLU 349 ? OE2 ? A GLU 348 OE2 
22 1 Y 1 A SER 350 ? OG  ? A SER 349 OG  
23 1 Y 1 A GLU 402 ? CG  ? A GLU 401 CG  
24 1 Y 1 A GLU 402 ? CD  ? A GLU 401 CD  
25 1 Y 1 A GLU 402 ? OE1 ? A GLU 401 OE1 
26 1 Y 1 A GLU 402 ? OE2 ? A GLU 401 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.18.2_3874: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EID 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     46.725 
_cell.length_a_esd                 ? 
_cell.length_b                     79.613 
_cell.length_b_esd                 ? 
_cell.length_c                     104.775 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EID 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EID 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.06 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          40.20 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Bis-Tris buffer pH 6.0, 25% PEG 5000, and 2.8 mM Sodium D/L-2-hydroxybutyrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97934 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97934 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EID 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.38 
_reflns.d_resolution_low                               29.11 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     80218 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.099 
_reflns.pdbx_Rpim_I_all                                0.027 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.095 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.38 
_reflns_shell.d_res_low                                     1.41 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3732 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.818 
_reflns_shell.pdbx_Rpim_I_all                               0.288 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.805 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.763 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EID 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.38 
_refine.ls_d_res_low                             29.11 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     80127 
_refine.ls_number_reflns_R_free                  3987 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.70 
_refine.ls_percent_reflns_R_free                 4.98 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1521 
_refine.ls_R_factor_R_free                       0.1662 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1513 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 15.18 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.11 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.38 
_refine_hist.d_res_low                        29.11 
_refine_hist.number_atoms_solvent             528 
_refine_hist.number_atoms_total               3769 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3199 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         42 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006  ? 3410 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.990  ? 4691 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 19.343 ? 491  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.088  ? 557  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.006  ? 609  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.38 1.40  . . 135 2550 94.00  . . . . 0.2172 . . . . . . . . . . . 0.2375 
'X-RAY DIFFRACTION' 1.40 1.42  . . 148 2638 98.00  . . . . 0.2020 . . . . . . . . . . . 0.2286 
'X-RAY DIFFRACTION' 1.42 1.44  . . 130 2646 100.00 . . . . 0.1910 . . . . . . . . . . . 0.1821 
'X-RAY DIFFRACTION' 1.44 1.46  . . 155 2707 100.00 . . . . 0.1779 . . . . . . . . . . . 0.2234 
'X-RAY DIFFRACTION' 1.46 1.48  . . 167 2673 100.00 . . . . 0.1692 . . . . . . . . . . . 0.1832 
'X-RAY DIFFRACTION' 1.48 1.50  . . 127 2698 100.00 . . . . 0.1626 . . . . . . . . . . . 0.1556 
'X-RAY DIFFRACTION' 1.50 1.52  . . 157 2662 100.00 . . . . 0.1577 . . . . . . . . . . . 0.1706 
'X-RAY DIFFRACTION' 1.52 1.55  . . 131 2735 100.00 . . . . 0.1523 . . . . . . . . . . . 0.2287 
'X-RAY DIFFRACTION' 1.55 1.58  . . 131 2690 100.00 . . . . 0.1500 . . . . . . . . . . . 0.1863 
'X-RAY DIFFRACTION' 1.58 1.60  . . 152 2678 100.00 . . . . 0.1483 . . . . . . . . . . . 0.1731 
'X-RAY DIFFRACTION' 1.60 1.63  . . 123 2711 100.00 . . . . 0.1453 . . . . . . . . . . . 0.1754 
'X-RAY DIFFRACTION' 1.63 1.67  . . 137 2748 100.00 . . . . 0.1459 . . . . . . . . . . . 0.1657 
'X-RAY DIFFRACTION' 1.67 1.70  . . 143 2678 100.00 . . . . 0.1401 . . . . . . . . . . . 0.1570 
'X-RAY DIFFRACTION' 1.70 1.74  . . 129 2737 100.00 . . . . 0.1441 . . . . . . . . . . . 0.1696 
'X-RAY DIFFRACTION' 1.74 1.79  . . 131 2716 100.00 . . . . 0.1450 . . . . . . . . . . . 0.1649 
'X-RAY DIFFRACTION' 1.79 1.84  . . 129 2720 100.00 . . . . 0.1483 . . . . . . . . . . . 0.1622 
'X-RAY DIFFRACTION' 1.84 1.89  . . 141 2716 100.00 . . . . 0.1537 . . . . . . . . . . . 0.1634 
'X-RAY DIFFRACTION' 1.89 1.95  . . 136 2744 100.00 . . . . 0.1518 . . . . . . . . . . . 0.1866 
'X-RAY DIFFRACTION' 1.95 2.02  . . 144 2722 100.00 . . . . 0.1501 . . . . . . . . . . . 0.1861 
'X-RAY DIFFRACTION' 2.02 2.10  . . 170 2698 100.00 . . . . 0.1493 . . . . . . . . . . . 0.1594 
'X-RAY DIFFRACTION' 2.10 2.20  . . 150 2706 100.00 . . . . 0.1454 . . . . . . . . . . . 0.1607 
'X-RAY DIFFRACTION' 2.20 2.31  . . 157 2735 100.00 . . . . 0.1530 . . . . . . . . . . . 0.1745 
'X-RAY DIFFRACTION' 2.31 2.46  . . 152 2737 100.00 . . . . 0.1547 . . . . . . . . . . . 0.1717 
'X-RAY DIFFRACTION' 2.46 2.65  . . 141 2763 100.00 . . . . 0.1566 . . . . . . . . . . . 0.1702 
'X-RAY DIFFRACTION' 2.65 2.91  . . 151 2759 100.00 . . . . 0.1601 . . . . . . . . . . . 0.1630 
'X-RAY DIFFRACTION' 2.91 3.33  . . 138 2790 100.00 . . . . 0.1566 . . . . . . . . . . . 0.1907 
'X-RAY DIFFRACTION' 3.33 4.20  . . 119 2846 100.00 . . . . 0.1354 . . . . . . . . . . . 0.1293 
'X-RAY DIFFRACTION' 4.20 29.11 . . 163 2937 100.00 . . . . 0.1361 . . . . . . . . . . . 0.1278 
# 
_struct.entry_id                     9EID 
_struct.title                        
'A broad-substrate spectrum lactate racemase A from Isosphaera pallida in complex with D-2-Hydroxybutyrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EID 
_struct_keywords.text            
'Catalytic activity, isomerase activity, racemase and epimerase activity racemase acting on hydroxy acids and derivatives, ISOMERASE' 
_struct_keywords.pdbx_keywords   ISOMERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
G N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    E8QWZ4_ISOPI 
_struct_ref.pdbx_db_accession          E8QWZ4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;RVTLDYGKTGLNVDLPDDRTLPPLTIRPAPPLDDPEAEVVRCLAEPIGSPPLLDLARGKRSACILVCDITRPVPNPVLLR
PILRTLHAAGLATQDILILVATGLHRPSTPAEKVEMLSEEIARTYRVEDHYGTRLEEHTYLGTTPNGVPAWIDSRYVQAD
LKIATGLIEPHLMAGYSGGRKLICPGIAAFETVKLWHGPRFLEHPLADCGFLEGNPVHEENTRIARMAGCDFIVNVTLDG
ARRITSVVAGDMEQAFLKGVAFVETVVKAAVPAPVDVVVTSSAGHPLDLTFYQAVKGLTGALPIVKPGGTIVIAAALAEG
LGSPEFQSLFEEHPTLEGFMEAILKEESFTVDQWQLEELAKVRRKARVKFVSDGVPAAVLSRCHVEPVATVELAVAQALE
QYGPEARVAVIPKGPYVLPVVDPT
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EID 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 425 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             E8QWZ4 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  425 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       426 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9EID 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      1 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   E8QWZ4 
_struct_ref_seq_dif.db_mon_id                    ? 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          ? 
_struct_ref_seq_dif.details                      'expression tag' 
_struct_ref_seq_dif.pdbx_auth_seq_num            2 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 17  ? THR A 21  ? PRO A 18  THR A 22  5 ? 5  
HELX_P HELX_P2  AA2 ASP A 35  ? GLU A 46  ? ASP A 36  GLU A 47  1 ? 12 
HELX_P HELX_P3  AA3 PRO A 52  ? ARG A 58  ? PRO A 53  ARG A 59  1 ? 7  
HELX_P HELX_P4  AA4 PRO A 75  ? ALA A 90  ? PRO A 76  ALA A 91  1 ? 16 
HELX_P HELX_P5  AA5 ALA A 93  ? GLN A 95  ? ALA A 94  GLN A 96  5 ? 3  
HELX_P HELX_P6  AA6 THR A 110 ? SER A 119 ? THR A 111 SER A 120 1 ? 10 
HELX_P HELX_P7  AA7 SER A 119 ? TYR A 126 ? SER A 120 TYR A 127 1 ? 8  
HELX_P HELX_P8  AA8 ARG A 135 ? GLU A 137 ? ARG A 136 GLU A 138 5 ? 3  
HELX_P HELX_P9  AA9 SER A 155 ? GLN A 159 ? SER A 156 GLN A 160 1 ? 5  
HELX_P HELX_P10 AB1 GLY A 179 ? ILE A 184 ? GLY A 180 ILE A 185 5 ? 6  
HELX_P HELX_P11 AB2 ALA A 190 ? HIS A 198 ? ALA A 191 HIS A 199 1 ? 9  
HELX_P HELX_P12 AB3 GLY A 199 ? GLU A 204 ? GLY A 200 GLU A 205 1 ? 6  
HELX_P HELX_P13 AB4 ASN A 216 ? GLY A 230 ? ASN A 217 GLY A 231 1 ? 15 
HELX_P HELX_P14 AB5 ASP A 252 ? THR A 266 ? ASP A 253 THR A 267 1 ? 15 
HELX_P HELX_P15 AB6 PRO A 287 ? LEU A 290 ? PRO A 288 LEU A 291 5 ? 4  
HELX_P HELX_P16 AB7 THR A 291 ? LEU A 303 ? THR A 292 LEU A 304 1 ? 13 
HELX_P HELX_P17 AB8 SER A 324 ? HIS A 334 ? SER A 325 HIS A 335 1 ? 11 
HELX_P HELX_P18 AB9 THR A 336 ? LEU A 345 ? THR A 337 LEU A 346 1 ? 10 
HELX_P HELX_P19 AC1 ASP A 353 ? LYS A 366 ? ASP A 354 LYS A 367 1 ? 14 
HELX_P HELX_P20 AC2 PRO A 377 ? ARG A 383 ? PRO A 378 ARG A 384 1 ? 7  
HELX_P HELX_P21 AC3 THR A 391 ? GLY A 404 ? THR A 392 GLY A 405 1 ? 14 
HELX_P HELX_P22 AC4 LYS A 414 ? VAL A 418 ? LYS A 415 VAL A 419 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A LYS 182 NZ  ? ? ? 1_555 C 4EY . C7 ? ? A LYS 183 A 4EY 502 1_555 ? ? ? ? ? ? ? 1.428 ? ? 
metalc1 metalc ?    ? A HIS 198 NE2 A ? ? 1_555 D NI  . NI ? ? A HIS 199 A NI  503 1_555 ? ? ? ? ? ? ? 2.054 ? ? 
metalc2 metalc ?    ? A HIS 198 NE2 B ? ? 1_555 D NI  . NI ? ? A HIS 199 A NI  503 1_555 ? ? ? ? ? ? ? 2.116 ? ? 
metalc3 metalc ?    ? C 4EY .   S7  ? ? ? 1_555 D NI  . NI ? ? A 4EY 502 A NI  503 1_555 ? ? ? ? ? ? ? 2.225 ? ? 
metalc4 metalc ?    ? C 4EY .   S2  ? ? ? 1_555 D NI  . NI ? ? A 4EY 502 A NI  503 1_555 ? ? ? ? ? ? ? 2.216 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 NE2 A A HIS 198 ? A HIS 199 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 NE2 B A HIS 198 ? A HIS 199 ? 1_555 8.4   ? 
2 NE2 A A HIS 198 ? A HIS 199 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 S7  ? C 4EY .   ? A 4EY 502 ? 1_555 94.4  ? 
3 NE2 B A HIS 198 ? A HIS 199 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 S7  ? C 4EY .   ? A 4EY 502 ? 1_555 91.6  ? 
4 NE2 A A HIS 198 ? A HIS 199 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 S2  ? C 4EY .   ? A 4EY 502 ? 1_555 93.4  ? 
5 NE2 B A HIS 198 ? A HIS 199 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 S2  ? C 4EY .   ? A 4EY 502 ? 1_555 96.1  ? 
6 S7  ? C 4EY .   ? A 4EY 502 ? 1_555 NI ? D NI . ? A NI 503 ? 1_555 S2  ? C 4EY .   ? A 4EY 502 ? 1_555 172.1 ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      4EY 
_pdbx_modification_feature.label_asym_id                      C 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     LYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      182 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       4EY 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        502 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      LYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       183 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C7 
_pdbx_modification_feature.modified_residue_id_linking_atom   NZ 
_pdbx_modification_feature.modified_residue_id                LYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        4EY 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 CYS 185 A . ? CYS 186 A PRO 186 A ? PRO 187 A 1 13.67 
2 HIS 286 A . ? HIS 287 A PRO 287 A ? PRO 288 A 1 6.56  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 6 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? parallel      
AA6 1 2 ? parallel      
AA6 2 3 ? parallel      
AA6 3 4 ? parallel      
AA6 4 5 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 2   ? LEU A 5   ? ARG A 3   LEU A 6   
AA1 2 LEU A 12  ? ASP A 15  ? LEU A 13  ASP A 16  
AA2 1 ARG A 127 ? ASP A 130 ? ARG A 128 ASP A 131 
AA2 2 ILE A 97  ? ALA A 102 ? ILE A 98  ALA A 103 
AA2 3 ALA A 63  ? CYS A 68  ? ALA A 64  CYS A 69  
AA2 4 LEU A 162 ? LEU A 168 ? LEU A 163 LEU A 169 
AA2 5 PHE A 233 ? LEU A 239 ? PHE A 234 LEU A 240 
AA2 6 ILE A 245 ? GLY A 251 ? ILE A 246 GLY A 252 
AA3 1 HIS A 139 ? THR A 144 ? HIS A 140 THR A 145 
AA3 2 PRO A 150 ? ASP A 154 ? PRO A 151 ASP A 155 
AA4 1 PRO A 171 ? HIS A 172 ? PRO A 172 HIS A 173 
AA4 2 GLY A 176 ? TYR A 177 ? GLY A 177 TYR A 178 
AA5 1 LYS A 269 ? VAL A 272 ? LYS A 270 VAL A 273 
AA5 2 LEU A 419 ? VAL A 422 ? LEU A 420 VAL A 423 
AA6 1 GLU A 387 ? PRO A 388 ? GLU A 388 PRO A 389 
AA6 2 ALA A 367 ? VAL A 372 ? ALA A 368 VAL A 373 
AA6 3 VAL A 306 ? ALA A 315 ? VAL A 307 ALA A 316 
AA6 4 VAL A 276 ? SER A 282 ? VAL A 277 SER A 283 
AA6 5 VAL A 409 ? ILE A 412 ? VAL A 410 ILE A 413 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 3   ? N VAL A 4   O VAL A 14  ? O VAL A 15  
AA2 1 2 O GLU A 129 ? O GLU A 130 N VAL A 101 ? N VAL A 102 
AA2 2 3 O ALA A 102 ? O ALA A 103 N VAL A 67  ? N VAL A 68  
AA2 3 4 N LEU A 66  ? N LEU A 67  O ILE A 164 ? O ILE A 165 
AA2 4 5 N ALA A 165 ? N ALA A 166 O PHE A 233 ? O PHE A 234 
AA2 5 6 N ASN A 236 ? N ASN A 237 O VAL A 249 ? O VAL A 250 
AA3 1 2 N GLY A 143 ? N GLY A 144 O ALA A 151 ? O ALA A 152 
AA4 1 2 N HIS A 172 ? N HIS A 173 O GLY A 176 ? O GLY A 177 
AA5 1 2 N VAL A 272 ? N VAL A 273 O VAL A 421 ? O VAL A 422 
AA6 1 2 O GLU A 387 ? O GLU A 388 N VAL A 369 ? N VAL A 370 
AA6 2 3 O VAL A 372 ? O VAL A 373 N ILE A 314 ? N ILE A 315 
AA6 3 4 O VAL A 313 ? O VAL A 314 N THR A 281 ? N THR A 282 
AA6 4 5 N VAL A 280 ? N VAL A 281 O ALA A 410 ? O ALA A 411 
# 
_pdbx_entry_details.entry_id                   9EID 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 8   ? ? -166.80 108.49 
2 1 SER A 120 ? ? 80.80   150.60 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
4EY C2   C  Y N 1   
4EY C3   C  Y N 2   
4EY C1   C  N N 3   
4EY C4   C  Y N 4   
4EY C5   C  Y N 5   
4EY C6   C  Y N 6   
4EY O2   O  N N 7   
4EY O2P  O  N N 8   
4EY P    P  N N 9   
4EY O3P  O  N N 10  
4EY O1P  O  N N 11  
4EY O5R  O  N N 12  
4EY C5R  C  N N 13  
4EY C4R  C  N R 14  
4EY O4R  O  N N 15  
4EY C3R  C  N S 16  
4EY O3R  O  N N 17  
4EY C2R  C  N R 18  
4EY O2R  O  N N 19  
4EY C1R  C  N R 20  
4EY N1   N  Y N 21  
4EY C7   C  N N 22  
4EY S7   S  N N 23  
4EY S2   S  N N 24  
4EY H1   H  N N 25  
4EY H2   H  N N 26  
4EY H3   H  N N 27  
4EY H4   H  N N 28  
4EY H5   H  N N 29  
4EY H6   H  N N 30  
4EY H7   H  N N 31  
4EY H8   H  N N 32  
4EY H9   H  N N 33  
4EY H10  H  N N 34  
4EY H11  H  N N 35  
4EY H12  H  N N 36  
4EY H13  H  N N 37  
4EY H14  H  N N 38  
4EY H15  H  N N 39  
ALA N    N  N N 40  
ALA CA   C  N S 41  
ALA C    C  N N 42  
ALA O    O  N N 43  
ALA CB   C  N N 44  
ALA OXT  O  N N 45  
ALA H    H  N N 46  
ALA H2   H  N N 47  
ALA HA   H  N N 48  
ALA HB1  H  N N 49  
ALA HB2  H  N N 50  
ALA HB3  H  N N 51  
ALA HXT  H  N N 52  
ARG N    N  N N 53  
ARG CA   C  N S 54  
ARG C    C  N N 55  
ARG O    O  N N 56  
ARG CB   C  N N 57  
ARG CG   C  N N 58  
ARG CD   C  N N 59  
ARG NE   N  N N 60  
ARG CZ   C  N N 61  
ARG NH1  N  N N 62  
ARG NH2  N  N N 63  
ARG OXT  O  N N 64  
ARG H    H  N N 65  
ARG H2   H  N N 66  
ARG HA   H  N N 67  
ARG HB2  H  N N 68  
ARG HB3  H  N N 69  
ARG HG2  H  N N 70  
ARG HG3  H  N N 71  
ARG HD2  H  N N 72  
ARG HD3  H  N N 73  
ARG HE   H  N N 74  
ARG HH11 H  N N 75  
ARG HH12 H  N N 76  
ARG HH21 H  N N 77  
ARG HH22 H  N N 78  
ARG HXT  H  N N 79  
ASN N    N  N N 80  
ASN CA   C  N S 81  
ASN C    C  N N 82  
ASN O    O  N N 83  
ASN CB   C  N N 84  
ASN CG   C  N N 85  
ASN OD1  O  N N 86  
ASN ND2  N  N N 87  
ASN OXT  O  N N 88  
ASN H    H  N N 89  
ASN H2   H  N N 90  
ASN HA   H  N N 91  
ASN HB2  H  N N 92  
ASN HB3  H  N N 93  
ASN HD21 H  N N 94  
ASN HD22 H  N N 95  
ASN HXT  H  N N 96  
ASP N    N  N N 97  
ASP CA   C  N S 98  
ASP C    C  N N 99  
ASP O    O  N N 100 
ASP CB   C  N N 101 
ASP CG   C  N N 102 
ASP OD1  O  N N 103 
ASP OD2  O  N N 104 
ASP OXT  O  N N 105 
ASP H    H  N N 106 
ASP H2   H  N N 107 
ASP HA   H  N N 108 
ASP HB2  H  N N 109 
ASP HB3  H  N N 110 
ASP HD2  H  N N 111 
ASP HXT  H  N N 112 
CYS N    N  N N 113 
CYS CA   C  N R 114 
CYS C    C  N N 115 
CYS O    O  N N 116 
CYS CB   C  N N 117 
CYS SG   S  N N 118 
CYS OXT  O  N N 119 
CYS H    H  N N 120 
CYS H2   H  N N 121 
CYS HA   H  N N 122 
CYS HB2  H  N N 123 
CYS HB3  H  N N 124 
CYS HG   H  N N 125 
CYS HXT  H  N N 126 
GLN N    N  N N 127 
GLN CA   C  N S 128 
GLN C    C  N N 129 
GLN O    O  N N 130 
GLN CB   C  N N 131 
GLN CG   C  N N 132 
GLN CD   C  N N 133 
GLN OE1  O  N N 134 
GLN NE2  N  N N 135 
GLN OXT  O  N N 136 
GLN H    H  N N 137 
GLN H2   H  N N 138 
GLN HA   H  N N 139 
GLN HB2  H  N N 140 
GLN HB3  H  N N 141 
GLN HG2  H  N N 142 
GLN HG3  H  N N 143 
GLN HE21 H  N N 144 
GLN HE22 H  N N 145 
GLN HXT  H  N N 146 
GLU N    N  N N 147 
GLU CA   C  N S 148 
GLU C    C  N N 149 
GLU O    O  N N 150 
GLU CB   C  N N 151 
GLU CG   C  N N 152 
GLU CD   C  N N 153 
GLU OE1  O  N N 154 
GLU OE2  O  N N 155 
GLU OXT  O  N N 156 
GLU H    H  N N 157 
GLU H2   H  N N 158 
GLU HA   H  N N 159 
GLU HB2  H  N N 160 
GLU HB3  H  N N 161 
GLU HG2  H  N N 162 
GLU HG3  H  N N 163 
GLU HE2  H  N N 164 
GLU HXT  H  N N 165 
GLY N    N  N N 166 
GLY CA   C  N N 167 
GLY C    C  N N 168 
GLY O    O  N N 169 
GLY OXT  O  N N 170 
GLY H    H  N N 171 
GLY H2   H  N N 172 
GLY HA2  H  N N 173 
GLY HA3  H  N N 174 
GLY HXT  H  N N 175 
HIS N    N  N N 176 
HIS CA   C  N S 177 
HIS C    C  N N 178 
HIS O    O  N N 179 
HIS CB   C  N N 180 
HIS CG   C  Y N 181 
HIS ND1  N  Y N 182 
HIS CD2  C  Y N 183 
HIS CE1  C  Y N 184 
HIS NE2  N  Y N 185 
HIS OXT  O  N N 186 
HIS H    H  N N 187 
HIS H2   H  N N 188 
HIS HA   H  N N 189 
HIS HB2  H  N N 190 
HIS HB3  H  N N 191 
HIS HD1  H  N N 192 
HIS HD2  H  N N 193 
HIS HE1  H  N N 194 
HIS HE2  H  N N 195 
HIS HXT  H  N N 196 
HOH O    O  N N 197 
HOH H1   H  N N 198 
HOH H2   H  N N 199 
ILE N    N  N N 200 
ILE CA   C  N S 201 
ILE C    C  N N 202 
ILE O    O  N N 203 
ILE CB   C  N S 204 
ILE CG1  C  N N 205 
ILE CG2  C  N N 206 
ILE CD1  C  N N 207 
ILE OXT  O  N N 208 
ILE H    H  N N 209 
ILE H2   H  N N 210 
ILE HA   H  N N 211 
ILE HB   H  N N 212 
ILE HG12 H  N N 213 
ILE HG13 H  N N 214 
ILE HG21 H  N N 215 
ILE HG22 H  N N 216 
ILE HG23 H  N N 217 
ILE HD11 H  N N 218 
ILE HD12 H  N N 219 
ILE HD13 H  N N 220 
ILE HXT  H  N N 221 
LEU N    N  N N 222 
LEU CA   C  N S 223 
LEU C    C  N N 224 
LEU O    O  N N 225 
LEU CB   C  N N 226 
LEU CG   C  N N 227 
LEU CD1  C  N N 228 
LEU CD2  C  N N 229 
LEU OXT  O  N N 230 
LEU H    H  N N 231 
LEU H2   H  N N 232 
LEU HA   H  N N 233 
LEU HB2  H  N N 234 
LEU HB3  H  N N 235 
LEU HG   H  N N 236 
LEU HD11 H  N N 237 
LEU HD12 H  N N 238 
LEU HD13 H  N N 239 
LEU HD21 H  N N 240 
LEU HD22 H  N N 241 
LEU HD23 H  N N 242 
LEU HXT  H  N N 243 
LYS N    N  N N 244 
LYS CA   C  N S 245 
LYS C    C  N N 246 
LYS O    O  N N 247 
LYS CB   C  N N 248 
LYS CG   C  N N 249 
LYS CD   C  N N 250 
LYS CE   C  N N 251 
LYS NZ   N  N N 252 
LYS OXT  O  N N 253 
LYS H    H  N N 254 
LYS H2   H  N N 255 
LYS HA   H  N N 256 
LYS HB2  H  N N 257 
LYS HB3  H  N N 258 
LYS HG2  H  N N 259 
LYS HG3  H  N N 260 
LYS HD2  H  N N 261 
LYS HD3  H  N N 262 
LYS HE2  H  N N 263 
LYS HE3  H  N N 264 
LYS HZ1  H  N N 265 
LYS HZ2  H  N N 266 
LYS HZ3  H  N N 267 
LYS HXT  H  N N 268 
MET N    N  N N 269 
MET CA   C  N S 270 
MET C    C  N N 271 
MET O    O  N N 272 
MET CB   C  N N 273 
MET CG   C  N N 274 
MET SD   S  N N 275 
MET CE   C  N N 276 
MET OXT  O  N N 277 
MET H    H  N N 278 
MET H2   H  N N 279 
MET HA   H  N N 280 
MET HB2  H  N N 281 
MET HB3  H  N N 282 
MET HG2  H  N N 283 
MET HG3  H  N N 284 
MET HE1  H  N N 285 
MET HE2  H  N N 286 
MET HE3  H  N N 287 
MET HXT  H  N N 288 
NI  NI   NI N N 289 
PHE N    N  N N 290 
PHE CA   C  N S 291 
PHE C    C  N N 292 
PHE O    O  N N 293 
PHE CB   C  N N 294 
PHE CG   C  Y N 295 
PHE CD1  C  Y N 296 
PHE CD2  C  Y N 297 
PHE CE1  C  Y N 298 
PHE CE2  C  Y N 299 
PHE CZ   C  Y N 300 
PHE OXT  O  N N 301 
PHE H    H  N N 302 
PHE H2   H  N N 303 
PHE HA   H  N N 304 
PHE HB2  H  N N 305 
PHE HB3  H  N N 306 
PHE HD1  H  N N 307 
PHE HD2  H  N N 308 
PHE HE1  H  N N 309 
PHE HE2  H  N N 310 
PHE HZ   H  N N 311 
PHE HXT  H  N N 312 
PO4 P    P  N N 313 
PO4 O1   O  N N 314 
PO4 O2   O  N N 315 
PO4 O3   O  N N 316 
PO4 O4   O  N N 317 
PRO N    N  N N 318 
PRO CA   C  N S 319 
PRO C    C  N N 320 
PRO O    O  N N 321 
PRO CB   C  N N 322 
PRO CG   C  N N 323 
PRO CD   C  N N 324 
PRO OXT  O  N N 325 
PRO H    H  N N 326 
PRO HA   H  N N 327 
PRO HB2  H  N N 328 
PRO HB3  H  N N 329 
PRO HG2  H  N N 330 
PRO HG3  H  N N 331 
PRO HD2  H  N N 332 
PRO HD3  H  N N 333 
PRO HXT  H  N N 334 
SER N    N  N N 335 
SER CA   C  N S 336 
SER C    C  N N 337 
SER O    O  N N 338 
SER CB   C  N N 339 
SER OG   O  N N 340 
SER OXT  O  N N 341 
SER H    H  N N 342 
SER H2   H  N N 343 
SER HA   H  N N 344 
SER HB2  H  N N 345 
SER HB3  H  N N 346 
SER HG   H  N N 347 
SER HXT  H  N N 348 
THR N    N  N N 349 
THR CA   C  N S 350 
THR C    C  N N 351 
THR O    O  N N 352 
THR CB   C  N R 353 
THR OG1  O  N N 354 
THR CG2  C  N N 355 
THR OXT  O  N N 356 
THR H    H  N N 357 
THR H2   H  N N 358 
THR HA   H  N N 359 
THR HB   H  N N 360 
THR HG1  H  N N 361 
THR HG21 H  N N 362 
THR HG22 H  N N 363 
THR HG23 H  N N 364 
THR HXT  H  N N 365 
TRP N    N  N N 366 
TRP CA   C  N S 367 
TRP C    C  N N 368 
TRP O    O  N N 369 
TRP CB   C  N N 370 
TRP CG   C  Y N 371 
TRP CD1  C  Y N 372 
TRP CD2  C  Y N 373 
TRP NE1  N  Y N 374 
TRP CE2  C  Y N 375 
TRP CE3  C  Y N 376 
TRP CZ2  C  Y N 377 
TRP CZ3  C  Y N 378 
TRP CH2  C  Y N 379 
TRP OXT  O  N N 380 
TRP H    H  N N 381 
TRP H2   H  N N 382 
TRP HA   H  N N 383 
TRP HB2  H  N N 384 
TRP HB3  H  N N 385 
TRP HD1  H  N N 386 
TRP HE1  H  N N 387 
TRP HE3  H  N N 388 
TRP HZ2  H  N N 389 
TRP HZ3  H  N N 390 
TRP HH2  H  N N 391 
TRP HXT  H  N N 392 
TYR N    N  N N 393 
TYR CA   C  N S 394 
TYR C    C  N N 395 
TYR O    O  N N 396 
TYR CB   C  N N 397 
TYR CG   C  Y N 398 
TYR CD1  C  Y N 399 
TYR CD2  C  Y N 400 
TYR CE1  C  Y N 401 
TYR CE2  C  Y N 402 
TYR CZ   C  Y N 403 
TYR OH   O  N N 404 
TYR OXT  O  N N 405 
TYR H    H  N N 406 
TYR H2   H  N N 407 
TYR HA   H  N N 408 
TYR HB2  H  N N 409 
TYR HB3  H  N N 410 
TYR HD1  H  N N 411 
TYR HD2  H  N N 412 
TYR HE1  H  N N 413 
TYR HE2  H  N N 414 
TYR HH   H  N N 415 
TYR HXT  H  N N 416 
UCU CAA  C  N N 417 
UCU CAB  C  N R 418 
UCU CAC  C  N N 419 
UCU CAD  C  N N 420 
UCU OAE  O  N N 421 
UCU OAF  O  N N 422 
UCU OAG  O  N N 423 
UCU H1   H  N N 424 
UCU H2   H  N N 425 
UCU H3   H  N N 426 
UCU H4   H  N N 427 
UCU H5   H  N N 428 
UCU H6   H  N N 429 
UCU H7   H  N N 430 
UCU H8   H  N N 431 
VAL N    N  N N 432 
VAL CA   C  N S 433 
VAL C    C  N N 434 
VAL O    O  N N 435 
VAL CB   C  N N 436 
VAL CG1  C  N N 437 
VAL CG2  C  N N 438 
VAL OXT  O  N N 439 
VAL H    H  N N 440 
VAL H2   H  N N 441 
VAL HA   H  N N 442 
VAL HB   H  N N 443 
VAL HG11 H  N N 444 
VAL HG12 H  N N 445 
VAL HG13 H  N N 446 
VAL HG21 H  N N 447 
VAL HG22 H  N N 448 
VAL HG23 H  N N 449 
VAL HXT  H  N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
4EY O4R C4R  sing N N 1   
4EY O4R C1R  sing N N 2   
4EY O3R C3R  sing N N 3   
4EY C4R C3R  sing N N 4   
4EY C4R C5R  sing N N 5   
4EY C1R N1   sing N N 6   
4EY C1R C2R  sing N N 7   
4EY O2  C1   doub N N 8   
4EY C3R C2R  sing N N 9   
4EY C6  N1   doub Y N 10  
4EY C6  C5   sing Y N 11  
4EY C5R O5R  sing N N 12  
4EY N1  C2   sing Y N 13  
4EY O2R C2R  sing N N 14  
4EY C1  C5   sing N N 15  
4EY C1  S2   sing N N 16  
4EY C5  C4   doub Y N 17  
4EY C2  C3   doub Y N 18  
4EY O5R P    sing N N 19  
4EY C4  C3   sing Y N 20  
4EY C3  C7   sing N N 21  
4EY C7  S7   doub N N 22  
4EY P   O3P  doub N N 23  
4EY P   O1P  sing N N 24  
4EY P   O2P  sing N N 25  
4EY C2  H1   sing N N 26  
4EY C4  H2   sing N N 27  
4EY C6  H3   sing N N 28  
4EY O2P H4   sing N N 29  
4EY O1P H5   sing N N 30  
4EY C5R H6   sing N N 31  
4EY C5R H7   sing N N 32  
4EY C4R H8   sing N N 33  
4EY C3R H9   sing N N 34  
4EY O3R H10  sing N N 35  
4EY C2R H11  sing N N 36  
4EY O2R H12  sing N N 37  
4EY C1R H13  sing N N 38  
4EY C7  H14  sing N N 39  
4EY S2  H15  sing N N 40  
ALA N   CA   sing N N 41  
ALA N   H    sing N N 42  
ALA N   H2   sing N N 43  
ALA CA  C    sing N N 44  
ALA CA  CB   sing N N 45  
ALA CA  HA   sing N N 46  
ALA C   O    doub N N 47  
ALA C   OXT  sing N N 48  
ALA CB  HB1  sing N N 49  
ALA CB  HB2  sing N N 50  
ALA CB  HB3  sing N N 51  
ALA OXT HXT  sing N N 52  
ARG N   CA   sing N N 53  
ARG N   H    sing N N 54  
ARG N   H2   sing N N 55  
ARG CA  C    sing N N 56  
ARG CA  CB   sing N N 57  
ARG CA  HA   sing N N 58  
ARG C   O    doub N N 59  
ARG C   OXT  sing N N 60  
ARG CB  CG   sing N N 61  
ARG CB  HB2  sing N N 62  
ARG CB  HB3  sing N N 63  
ARG CG  CD   sing N N 64  
ARG CG  HG2  sing N N 65  
ARG CG  HG3  sing N N 66  
ARG CD  NE   sing N N 67  
ARG CD  HD2  sing N N 68  
ARG CD  HD3  sing N N 69  
ARG NE  CZ   sing N N 70  
ARG NE  HE   sing N N 71  
ARG CZ  NH1  sing N N 72  
ARG CZ  NH2  doub N N 73  
ARG NH1 HH11 sing N N 74  
ARG NH1 HH12 sing N N 75  
ARG NH2 HH21 sing N N 76  
ARG NH2 HH22 sing N N 77  
ARG OXT HXT  sing N N 78  
ASN N   CA   sing N N 79  
ASN N   H    sing N N 80  
ASN N   H2   sing N N 81  
ASN CA  C    sing N N 82  
ASN CA  CB   sing N N 83  
ASN CA  HA   sing N N 84  
ASN C   O    doub N N 85  
ASN C   OXT  sing N N 86  
ASN CB  CG   sing N N 87  
ASN CB  HB2  sing N N 88  
ASN CB  HB3  sing N N 89  
ASN CG  OD1  doub N N 90  
ASN CG  ND2  sing N N 91  
ASN ND2 HD21 sing N N 92  
ASN ND2 HD22 sing N N 93  
ASN OXT HXT  sing N N 94  
ASP N   CA   sing N N 95  
ASP N   H    sing N N 96  
ASP N   H2   sing N N 97  
ASP CA  C    sing N N 98  
ASP CA  CB   sing N N 99  
ASP CA  HA   sing N N 100 
ASP C   O    doub N N 101 
ASP C   OXT  sing N N 102 
ASP CB  CG   sing N N 103 
ASP CB  HB2  sing N N 104 
ASP CB  HB3  sing N N 105 
ASP CG  OD1  doub N N 106 
ASP CG  OD2  sing N N 107 
ASP OD2 HD2  sing N N 108 
ASP OXT HXT  sing N N 109 
CYS N   CA   sing N N 110 
CYS N   H    sing N N 111 
CYS N   H2   sing N N 112 
CYS CA  C    sing N N 113 
CYS CA  CB   sing N N 114 
CYS CA  HA   sing N N 115 
CYS C   O    doub N N 116 
CYS C   OXT  sing N N 117 
CYS CB  SG   sing N N 118 
CYS CB  HB2  sing N N 119 
CYS CB  HB3  sing N N 120 
CYS SG  HG   sing N N 121 
CYS OXT HXT  sing N N 122 
GLN N   CA   sing N N 123 
GLN N   H    sing N N 124 
GLN N   H2   sing N N 125 
GLN CA  C    sing N N 126 
GLN CA  CB   sing N N 127 
GLN CA  HA   sing N N 128 
GLN C   O    doub N N 129 
GLN C   OXT  sing N N 130 
GLN CB  CG   sing N N 131 
GLN CB  HB2  sing N N 132 
GLN CB  HB3  sing N N 133 
GLN CG  CD   sing N N 134 
GLN CG  HG2  sing N N 135 
GLN CG  HG3  sing N N 136 
GLN CD  OE1  doub N N 137 
GLN CD  NE2  sing N N 138 
GLN NE2 HE21 sing N N 139 
GLN NE2 HE22 sing N N 140 
GLN OXT HXT  sing N N 141 
GLU N   CA   sing N N 142 
GLU N   H    sing N N 143 
GLU N   H2   sing N N 144 
GLU CA  C    sing N N 145 
GLU CA  CB   sing N N 146 
GLU CA  HA   sing N N 147 
GLU C   O    doub N N 148 
GLU C   OXT  sing N N 149 
GLU CB  CG   sing N N 150 
GLU CB  HB2  sing N N 151 
GLU CB  HB3  sing N N 152 
GLU CG  CD   sing N N 153 
GLU CG  HG2  sing N N 154 
GLU CG  HG3  sing N N 155 
GLU CD  OE1  doub N N 156 
GLU CD  OE2  sing N N 157 
GLU OE2 HE2  sing N N 158 
GLU OXT HXT  sing N N 159 
GLY N   CA   sing N N 160 
GLY N   H    sing N N 161 
GLY N   H2   sing N N 162 
GLY CA  C    sing N N 163 
GLY CA  HA2  sing N N 164 
GLY CA  HA3  sing N N 165 
GLY C   O    doub N N 166 
GLY C   OXT  sing N N 167 
GLY OXT HXT  sing N N 168 
HIS N   CA   sing N N 169 
HIS N   H    sing N N 170 
HIS N   H2   sing N N 171 
HIS CA  C    sing N N 172 
HIS CA  CB   sing N N 173 
HIS CA  HA   sing N N 174 
HIS C   O    doub N N 175 
HIS C   OXT  sing N N 176 
HIS CB  CG   sing N N 177 
HIS CB  HB2  sing N N 178 
HIS CB  HB3  sing N N 179 
HIS CG  ND1  sing Y N 180 
HIS CG  CD2  doub Y N 181 
HIS ND1 CE1  doub Y N 182 
HIS ND1 HD1  sing N N 183 
HIS CD2 NE2  sing Y N 184 
HIS CD2 HD2  sing N N 185 
HIS CE1 NE2  sing Y N 186 
HIS CE1 HE1  sing N N 187 
HIS NE2 HE2  sing N N 188 
HIS OXT HXT  sing N N 189 
HOH O   H1   sing N N 190 
HOH O   H2   sing N N 191 
ILE N   CA   sing N N 192 
ILE N   H    sing N N 193 
ILE N   H2   sing N N 194 
ILE CA  C    sing N N 195 
ILE CA  CB   sing N N 196 
ILE CA  HA   sing N N 197 
ILE C   O    doub N N 198 
ILE C   OXT  sing N N 199 
ILE CB  CG1  sing N N 200 
ILE CB  CG2  sing N N 201 
ILE CB  HB   sing N N 202 
ILE CG1 CD1  sing N N 203 
ILE CG1 HG12 sing N N 204 
ILE CG1 HG13 sing N N 205 
ILE CG2 HG21 sing N N 206 
ILE CG2 HG22 sing N N 207 
ILE CG2 HG23 sing N N 208 
ILE CD1 HD11 sing N N 209 
ILE CD1 HD12 sing N N 210 
ILE CD1 HD13 sing N N 211 
ILE OXT HXT  sing N N 212 
LEU N   CA   sing N N 213 
LEU N   H    sing N N 214 
LEU N   H2   sing N N 215 
LEU CA  C    sing N N 216 
LEU CA  CB   sing N N 217 
LEU CA  HA   sing N N 218 
LEU C   O    doub N N 219 
LEU C   OXT  sing N N 220 
LEU CB  CG   sing N N 221 
LEU CB  HB2  sing N N 222 
LEU CB  HB3  sing N N 223 
LEU CG  CD1  sing N N 224 
LEU CG  CD2  sing N N 225 
LEU CG  HG   sing N N 226 
LEU CD1 HD11 sing N N 227 
LEU CD1 HD12 sing N N 228 
LEU CD1 HD13 sing N N 229 
LEU CD2 HD21 sing N N 230 
LEU CD2 HD22 sing N N 231 
LEU CD2 HD23 sing N N 232 
LEU OXT HXT  sing N N 233 
LYS N   CA   sing N N 234 
LYS N   H    sing N N 235 
LYS N   H2   sing N N 236 
LYS CA  C    sing N N 237 
LYS CA  CB   sing N N 238 
LYS CA  HA   sing N N 239 
LYS C   O    doub N N 240 
LYS C   OXT  sing N N 241 
LYS CB  CG   sing N N 242 
LYS CB  HB2  sing N N 243 
LYS CB  HB3  sing N N 244 
LYS CG  CD   sing N N 245 
LYS CG  HG2  sing N N 246 
LYS CG  HG3  sing N N 247 
LYS CD  CE   sing N N 248 
LYS CD  HD2  sing N N 249 
LYS CD  HD3  sing N N 250 
LYS CE  NZ   sing N N 251 
LYS CE  HE2  sing N N 252 
LYS CE  HE3  sing N N 253 
LYS NZ  HZ1  sing N N 254 
LYS NZ  HZ2  sing N N 255 
LYS NZ  HZ3  sing N N 256 
LYS OXT HXT  sing N N 257 
MET N   CA   sing N N 258 
MET N   H    sing N N 259 
MET N   H2   sing N N 260 
MET CA  C    sing N N 261 
MET CA  CB   sing N N 262 
MET CA  HA   sing N N 263 
MET C   O    doub N N 264 
MET C   OXT  sing N N 265 
MET CB  CG   sing N N 266 
MET CB  HB2  sing N N 267 
MET CB  HB3  sing N N 268 
MET CG  SD   sing N N 269 
MET CG  HG2  sing N N 270 
MET CG  HG3  sing N N 271 
MET SD  CE   sing N N 272 
MET CE  HE1  sing N N 273 
MET CE  HE2  sing N N 274 
MET CE  HE3  sing N N 275 
MET OXT HXT  sing N N 276 
PHE N   CA   sing N N 277 
PHE N   H    sing N N 278 
PHE N   H2   sing N N 279 
PHE CA  C    sing N N 280 
PHE CA  CB   sing N N 281 
PHE CA  HA   sing N N 282 
PHE C   O    doub N N 283 
PHE C   OXT  sing N N 284 
PHE CB  CG   sing N N 285 
PHE CB  HB2  sing N N 286 
PHE CB  HB3  sing N N 287 
PHE CG  CD1  doub Y N 288 
PHE CG  CD2  sing Y N 289 
PHE CD1 CE1  sing Y N 290 
PHE CD1 HD1  sing N N 291 
PHE CD2 CE2  doub Y N 292 
PHE CD2 HD2  sing N N 293 
PHE CE1 CZ   doub Y N 294 
PHE CE1 HE1  sing N N 295 
PHE CE2 CZ   sing Y N 296 
PHE CE2 HE2  sing N N 297 
PHE CZ  HZ   sing N N 298 
PHE OXT HXT  sing N N 299 
PO4 P   O1   doub N N 300 
PO4 P   O2   sing N N 301 
PO4 P   O3   sing N N 302 
PO4 P   O4   sing N N 303 
PRO N   CA   sing N N 304 
PRO N   CD   sing N N 305 
PRO N   H    sing N N 306 
PRO CA  C    sing N N 307 
PRO CA  CB   sing N N 308 
PRO CA  HA   sing N N 309 
PRO C   O    doub N N 310 
PRO C   OXT  sing N N 311 
PRO CB  CG   sing N N 312 
PRO CB  HB2  sing N N 313 
PRO CB  HB3  sing N N 314 
PRO CG  CD   sing N N 315 
PRO CG  HG2  sing N N 316 
PRO CG  HG3  sing N N 317 
PRO CD  HD2  sing N N 318 
PRO CD  HD3  sing N N 319 
PRO OXT HXT  sing N N 320 
SER N   CA   sing N N 321 
SER N   H    sing N N 322 
SER N   H2   sing N N 323 
SER CA  C    sing N N 324 
SER CA  CB   sing N N 325 
SER CA  HA   sing N N 326 
SER C   O    doub N N 327 
SER C   OXT  sing N N 328 
SER CB  OG   sing N N 329 
SER CB  HB2  sing N N 330 
SER CB  HB3  sing N N 331 
SER OG  HG   sing N N 332 
SER OXT HXT  sing N N 333 
THR N   CA   sing N N 334 
THR N   H    sing N N 335 
THR N   H2   sing N N 336 
THR CA  C    sing N N 337 
THR CA  CB   sing N N 338 
THR CA  HA   sing N N 339 
THR C   O    doub N N 340 
THR C   OXT  sing N N 341 
THR CB  OG1  sing N N 342 
THR CB  CG2  sing N N 343 
THR CB  HB   sing N N 344 
THR OG1 HG1  sing N N 345 
THR CG2 HG21 sing N N 346 
THR CG2 HG22 sing N N 347 
THR CG2 HG23 sing N N 348 
THR OXT HXT  sing N N 349 
TRP N   CA   sing N N 350 
TRP N   H    sing N N 351 
TRP N   H2   sing N N 352 
TRP CA  C    sing N N 353 
TRP CA  CB   sing N N 354 
TRP CA  HA   sing N N 355 
TRP C   O    doub N N 356 
TRP C   OXT  sing N N 357 
TRP CB  CG   sing N N 358 
TRP CB  HB2  sing N N 359 
TRP CB  HB3  sing N N 360 
TRP CG  CD1  doub Y N 361 
TRP CG  CD2  sing Y N 362 
TRP CD1 NE1  sing Y N 363 
TRP CD1 HD1  sing N N 364 
TRP CD2 CE2  doub Y N 365 
TRP CD2 CE3  sing Y N 366 
TRP NE1 CE2  sing Y N 367 
TRP NE1 HE1  sing N N 368 
TRP CE2 CZ2  sing Y N 369 
TRP CE3 CZ3  doub Y N 370 
TRP CE3 HE3  sing N N 371 
TRP CZ2 CH2  doub Y N 372 
TRP CZ2 HZ2  sing N N 373 
TRP CZ3 CH2  sing Y N 374 
TRP CZ3 HZ3  sing N N 375 
TRP CH2 HH2  sing N N 376 
TRP OXT HXT  sing N N 377 
TYR N   CA   sing N N 378 
TYR N   H    sing N N 379 
TYR N   H2   sing N N 380 
TYR CA  C    sing N N 381 
TYR CA  CB   sing N N 382 
TYR CA  HA   sing N N 383 
TYR C   O    doub N N 384 
TYR C   OXT  sing N N 385 
TYR CB  CG   sing N N 386 
TYR CB  HB2  sing N N 387 
TYR CB  HB3  sing N N 388 
TYR CG  CD1  doub Y N 389 
TYR CG  CD2  sing Y N 390 
TYR CD1 CE1  sing Y N 391 
TYR CD1 HD1  sing N N 392 
TYR CD2 CE2  doub Y N 393 
TYR CD2 HD2  sing N N 394 
TYR CE1 CZ   doub Y N 395 
TYR CE1 HE1  sing N N 396 
TYR CE2 CZ   sing Y N 397 
TYR CE2 HE2  sing N N 398 
TYR CZ  OH   sing N N 399 
TYR OH  HH   sing N N 400 
TYR OXT HXT  sing N N 401 
UCU OAG CAB  sing N N 402 
UCU CAC CAD  sing N N 403 
UCU CAC CAB  sing N N 404 
UCU CAB CAA  sing N N 405 
UCU CAA OAE  doub N N 406 
UCU CAA OAF  sing N N 407 
UCU CAB H1   sing N N 408 
UCU CAC H2   sing N N 409 
UCU CAC H3   sing N N 410 
UCU CAD H4   sing N N 411 
UCU CAD H5   sing N N 412 
UCU CAD H6   sing N N 413 
UCU OAF H7   sing N N 414 
UCU OAG H8   sing N N 415 
VAL N   CA   sing N N 416 
VAL N   H    sing N N 417 
VAL N   H2   sing N N 418 
VAL CA  C    sing N N 419 
VAL CA  CB   sing N N 420 
VAL CA  HA   sing N N 421 
VAL C   O    doub N N 422 
VAL C   OXT  sing N N 423 
VAL CB  CG1  sing N N 424 
VAL CB  CG2  sing N N 425 
VAL CB  HB   sing N N 426 
VAL CG1 HG11 sing N N 427 
VAL CG1 HG12 sing N N 428 
VAL CG1 HG13 sing N N 429 
VAL CG2 HG21 sing N N 430 
VAL CG2 HG22 sing N N 431 
VAL CG2 HG23 sing N N 432 
VAL OXT HXT  sing N N 433 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' GM128959 1 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' GM140931 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9EIA 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EID 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021402 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012561 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009544 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
NI 
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 1   ? -20.408 -31.531 14.736  1.00 27.55 ?  2    ALA A N   1 
ATOM   2    C  CA  . ALA A 1 1   ? -21.083 -30.461 14.003  1.00 22.00 ?  2    ALA A CA  1 
ATOM   3    C  C   . ALA A 1 1   ? -20.099 -29.770 13.067  1.00 16.33 ?  2    ALA A C   1 
ATOM   4    O  O   . ALA A 1 1   ? -19.341 -28.902 13.493  1.00 17.89 ?  2    ALA A O   1 
ATOM   5    C  CB  . ALA A 1 1   ? -21.686 -29.456 14.976  1.00 24.09 ?  2    ALA A CB  1 
ATOM   6    N  N   . ARG A 1 2   ? -20.110 -30.159 11.797  1.00 15.31 ?  3    ARG A N   1 
ATOM   7    C  CA  . ARG A 1 2   ? -19.206 -29.569 10.820  1.00 14.95 ?  3    ARG A CA  1 
ATOM   8    C  C   . ARG A 1 2   ? -19.766 -28.249 10.313  1.00 14.98 ?  3    ARG A C   1 
ATOM   9    O  O   . ARG A 1 2   ? -20.962 -28.128 10.037  1.00 15.48 ?  3    ARG A O   1 
ATOM   10   C  CB  . ARG A 1 2   ? -19.003 -30.529 9.655   1.00 16.41 ?  3    ARG A CB  1 
ATOM   11   C  CG  . ARG A 1 2   ? -18.340 -31.826 10.100  1.00 16.29 ?  3    ARG A CG  1 
ATOM   12   C  CD  . ARG A 1 2   ? -17.887 -32.678 8.932   1.00 22.21 ?  3    ARG A CD  1 
ATOM   13   N  NE  . ARG A 1 2   ? -17.370 -33.966 9.392   1.00 26.17 ?  3    ARG A NE  1 
ATOM   14   C  CZ  . ARG A 1 2   ? -16.099 -34.185 9.720   1.00 27.34 ?  3    ARG A CZ  1 
ATOM   15   N  NH1 . ARG A 1 2   ? -15.215 -33.203 9.640   1.00 26.94 ?  3    ARG A NH1 1 
ATOM   16   N  NH2 . ARG A 1 2   ? -15.710 -35.384 10.134  1.00 28.04 ?  3    ARG A NH2 1 
ATOM   17   N  N   . VAL A 1 3   ? -18.893 -27.249 10.207  1.00 12.83 ?  4    VAL A N   1 
ATOM   18   C  CA  . VAL A 1 3   ? -19.286 -25.927 9.741   1.00 12.39 ?  4    VAL A CA  1 
ATOM   19   C  C   . VAL A 1 3   ? -18.133 -25.362 8.928   1.00 11.48 ?  4    VAL A C   1 
ATOM   20   O  O   . VAL A 1 3   ? -16.965 -25.645 9.199   1.00 12.75 ?  4    VAL A O   1 
ATOM   21   C  CB  . VAL A 1 3   ? -19.642 -25.023 10.950  1.00 14.40 ?  4    VAL A CB  1 
ATOM   22   C  CG1 . VAL A 1 3   ? -18.455 -24.865 11.888  1.00 21.83 ?  4    VAL A CG1 1 
ATOM   23   C  CG2 . VAL A 1 3   ? -20.157 -23.689 10.493  1.00 21.18 ?  4    VAL A CG2 1 
ATOM   24   N  N   . THR A 1 4   ? -18.453 -24.554 7.920   1.00 9.50  ?  5    THR A N   1 
ATOM   25   C  CA  . THR A 1 4   ? -17.435 -23.856 7.141   1.00 9.26  ?  5    THR A CA  1 
ATOM   26   C  C   . THR A 1 4   ? -17.457 -22.394 7.561   1.00 9.56  ?  5    THR A C   1 
ATOM   27   O  O   . THR A 1 4   ? -18.436 -21.687 7.299   1.00 11.57 ?  5    THR A O   1 
ATOM   28   C  CB  . THR A 1 4   ? -17.701 -23.988 5.642   1.00 10.39 ?  5    THR A CB  1 
ATOM   29   O  OG1 . THR A 1 4   ? -17.664 -25.374 5.276   1.00 11.60 ?  5    THR A OG1 1 
ATOM   30   C  CG2 . THR A 1 4   ? -16.625 -23.266 4.835   1.00 10.86 ?  5    THR A CG2 1 
ATOM   31   N  N   . LEU A 1 5   ? -16.398 -21.945 8.234   1.00 8.40  ?  6    LEU A N   1 
ATOM   32   C  CA  . LEU A 1 5   ? -16.288 -20.533 8.593   1.00 7.77  ?  6    LEU A CA  1 
ATOM   33   C  C   . LEU A 1 5   ? -15.761 -19.754 7.393   1.00 9.09  ?  6    LEU A C   1 
ATOM   34   O  O   . LEU A 1 5   ? -14.944 -20.261 6.621   1.00 9.42  ?  6    LEU A O   1 
ATOM   35   C  CB  . LEU A 1 5   ? -15.306 -20.359 9.756   1.00 9.69  ?  6    LEU A CB  1 
ATOM   36   C  CG  . LEU A 1 5   ? -15.614 -21.093 11.059  1.00 9.23  ?  6    LEU A CG  1 
ATOM   37   C  CD1 . LEU A 1 5   ? -14.561 -20.771 12.121  1.00 9.55  ?  6    LEU A CD1 1 
ATOM   38   C  CD2 . LEU A 1 5   ? -17.009 -20.730 11.565  1.00 11.45 ?  6    LEU A CD2 1 
ATOM   39   N  N   . ASP A 1 6   ? -16.194 -18.500 7.251   1.00 8.10  ?  7    ASP A N   1 
ATOM   40   C  CA  . ASP A 1 6   ? -15.619 -17.665 6.210   1.00 8.52  ?  7    ASP A CA  1 
ATOM   41   C  C   . ASP A 1 6   ? -14.142 -17.466 6.536   1.00 7.76  ?  7    ASP A C   1 
ATOM   42   O  O   . ASP A 1 6   ? -13.778 -17.231 7.693   1.00 8.53  ?  7    ASP A O   1 
ATOM   43   C  CB  . ASP A 1 6   ? -16.283 -16.291 6.206   1.00 9.44  ?  7    ASP A CB  1 
ATOM   44   C  CG  . ASP A 1 6   ? -17.651 -16.285 5.538   1.00 12.07 ?  7    ASP A CG  1 
ATOM   45   O  OD1 . ASP A 1 6   ? -18.062 -17.305 4.945   1.00 12.36 ?  7    ASP A OD1 1 
ATOM   46   O  OD2 . ASP A 1 6   ? -18.312 -15.228 5.583   1.00 12.12 -1 7    ASP A OD2 1 
ATOM   47   N  N   . TYR A 1 7   ? -13.283 -17.550 5.521   1.00 7.85  ?  8    TYR A N   1 
ATOM   48   C  CA  . TYR A 1 7   ? -11.844 -17.529 5.759   1.00 7.48  ?  8    TYR A CA  1 
ATOM   49   C  C   . TYR A 1 7   ? -11.118 -17.310 4.443   1.00 8.23  ?  8    TYR A C   1 
ATOM   50   O  O   . TYR A 1 7   ? -11.110 -18.191 3.577   1.00 7.85  ?  8    TYR A O   1 
ATOM   51   C  CB  . TYR A 1 7   ? -11.401 -18.851 6.397   1.00 7.26  ?  8    TYR A CB  1 
ATOM   52   C  CG  . TYR A 1 7   ? -9.954  -18.870 6.861   1.00 7.94  ?  8    TYR A CG  1 
ATOM   53   C  CD1 . TYR A 1 7   ? -9.615  -18.476 8.155   1.00 8.88  ?  8    TYR A CD1 1 
ATOM   54   C  CD2 . TYR A 1 7   ? -8.931  -19.318 6.022   1.00 9.06  ?  8    TYR A CD2 1 
ATOM   55   C  CE1 . TYR A 1 7   ? -8.308  -18.527 8.595   1.00 10.10 ?  8    TYR A CE1 1 
ATOM   56   C  CE2 . TYR A 1 7   ? -7.620  -19.346 6.446   1.00 9.71  ?  8    TYR A CE2 1 
ATOM   57   C  CZ  . TYR A 1 7   ? -7.312  -18.953 7.732   1.00 11.02 ?  8    TYR A CZ  1 
ATOM   58   O  OH  . TYR A 1 7   ? -5.998  -18.989 8.166   1.00 13.17 ?  8    TYR A OH  1 
ATOM   59   N  N   . GLY A 1 8   ? -10.543 -16.127 4.260   1.00 7.76  ?  9    GLY A N   1 
ATOM   60   C  CA  . GLY A 1 8   ? -9.850  -15.848 3.011   1.00 9.01  ?  9    GLY A CA  1 
ATOM   61   C  C   . GLY A 1 8   ? -10.720 -16.133 1.806   1.00 8.65  ?  9    GLY A C   1 
ATOM   62   O  O   . GLY A 1 8   ? -11.935 -15.905 1.819   1.00 8.49  ?  9    GLY A O   1 
ATOM   63   N  N   . LYS A 1 9   ? -10.112 -16.712 0.776   1.00 10.21 ?  10   LYS A N   1 
ATOM   64   C  CA  . LYS A 1 9   ? -10.828 -17.058 -0.444  1.00 10.34 ?  10   LYS A CA  1 
ATOM   65   C  C   . LYS A 1 9   ? -11.366 -18.480 -0.440  1.00 11.85 ?  10   LYS A C   1 
ATOM   66   O  O   . LYS A 1 9   ? -11.954 -18.904 -1.441  1.00 13.38 ?  10   LYS A O   1 
ATOM   67   C  CB  . LYS A 1 9   ? -9.918  -16.856 -1.654  1.00 11.39 ?  10   LYS A CB  1 
ATOM   68   C  CG  . LYS A 1 9   ? -9.398  -15.439 -1.754  1.00 12.75 ?  10   LYS A CG  1 
ATOM   69   C  CD  . LYS A 1 9   ? -8.612  -15.233 -3.019  1.00 16.54 ?  10   LYS A CD  1 
ATOM   70   C  CE  . LYS A 1 9   ? -8.215  -13.778 -3.154  1.00 17.83 ?  10   LYS A CE  1 
ATOM   71   N  NZ  . LYS A 1 9   ? -7.087  -13.627 -4.122  1.00 20.24 ?  10   LYS A NZ  1 
ATOM   72   N  N   . THR A 1 10  ? -11.199 -19.217 0.656   1.00 9.65  ?  11   THR A N   1 
ATOM   73   C  CA  . THR A 1 10  ? -11.440 -20.654 0.677   1.00 9.93  ?  11   THR A CA  1 
ATOM   74   C  C   . THR A 1 10  ? -12.538 -21.111 1.618   1.00 10.00 ?  11   THR A C   1 
ATOM   75   O  O   . THR A 1 10  ? -13.124 -22.168 1.377   1.00 11.78 ?  11   THR A O   1 
ATOM   76   C  CB  . THR A 1 10  ? -10.156 -21.414 1.084   1.00 11.92 ?  11   THR A CB  1 
ATOM   77   O  OG1 . THR A 1 10  ? -9.731  -21.002 2.388   1.00 10.90 ?  11   THR A OG1 1 
ATOM   78   C  CG2 . THR A 1 10  ? -9.023  -21.195 0.092   1.00 12.36 ?  11   THR A CG2 1 
ATOM   79   N  N   . GLY A 1 11  ? -12.798 -20.391 2.696   1.00 8.52  ?  12   GLY A N   1 
ATOM   80   C  CA  . GLY A 1 11  ? -13.480 -20.964 3.837   1.00 8.10  ?  12   GLY A CA  1 
ATOM   81   C  C   . GLY A 1 11  ? -12.539 -21.837 4.649   1.00 8.29  ?  12   GLY A C   1 
ATOM   82   O  O   . GLY A 1 11  ? -11.402 -22.113 4.269   1.00 9.71  ?  12   GLY A O   1 
ATOM   83   N  N   . LEU A 1 12  ? -13.028 -22.259 5.815   1.00 7.83  ?  13   LEU A N   1 
ATOM   84   C  CA  . LEU A 1 12  ? -12.250 -23.079 6.742   1.00 8.63  ?  13   LEU A CA  1 
ATOM   85   C  C   . LEU A 1 12  ? -13.190 -24.114 7.332   1.00 8.87  ?  13   LEU A C   1 
ATOM   86   O  O   . LEU A 1 12  ? -14.208 -23.750 7.919   1.00 8.71  ?  13   LEU A O   1 
ATOM   87   C  CB  . LEU A 1 12  ? -11.669 -22.204 7.853   1.00 8.83  ?  13   LEU A CB  1 
ATOM   88   C  CG  . LEU A 1 12  ? -10.784 -22.927 8.872   1.00 8.51  ?  13   LEU A CG  1 
ATOM   89   C  CD1 . LEU A 1 12  ? -9.479  -23.424 8.227   1.00 10.18 ?  13   LEU A CD1 1 
ATOM   90   C  CD2 . LEU A 1 12  ? -10.492 -22.032 10.070  1.00 9.75  ?  13   LEU A CD2 1 
ATOM   91   N  N   . ASN A 1 13  ? -12.871 -25.401 7.165   1.00 8.30  ?  14   ASN A N   1 
ATOM   92   C  CA  . ASN A 1 13  ? -13.769 -26.478 7.579   1.00 9.39  ?  14   ASN A CA  1 
ATOM   93   C  C   . ASN A 1 13  ? -13.447 -26.909 9.004   1.00 9.03  ?  14   ASN A C   1 
ATOM   94   O  O   . ASN A 1 13  ? -12.383 -27.479 9.271   1.00 10.41 ?  14   ASN A O   1 
ATOM   95   C  CB  . ASN A 1 13  ? -13.710 -27.647 6.604   1.00 9.67  ?  14   ASN A CB  1 
ATOM   96   C  CG  . ASN A 1 13  ? -14.579 -27.414 5.408   1.00 11.09 ?  14   ASN A CG  1 
ATOM   97   O  OD1 . ASN A 1 13  ? -15.230 -26.375 5.307   1.00 12.99 ?  14   ASN A OD1 1 
ATOM   98   N  ND2 . ASN A 1 13  ? -14.602 -28.363 4.490   1.00 10.75 ?  14   ASN A ND2 1 
ATOM   99   N  N   . VAL A 1 14  ? -14.375 -26.633 9.917   1.00 8.72  ?  15   VAL A N   1 
ATOM   100  C  CA  . VAL A 1 14  ? -14.192 -26.868 11.342  1.00 9.11  ?  15   VAL A CA  1 
ATOM   101  C  C   . VAL A 1 14  ? -15.190 -27.924 11.797  1.00 10.87 ?  15   VAL A C   1 
ATOM   102  O  O   . VAL A 1 14  ? -16.305 -28.010 11.277  1.00 13.60 ?  15   VAL A O   1 
ATOM   103  C  CB  . VAL A 1 14  ? -14.416 -25.545 12.115  1.00 10.31 ?  15   VAL A CB  1 
ATOM   104  C  CG1 . VAL A 1 14  ? -14.266 -25.759 13.613  1.00 13.15 ?  15   VAL A CG1 1 
ATOM   105  C  CG2 . VAL A 1 14  ? -13.463 -24.464 11.631  1.00 9.59  ?  15   VAL A CG2 1 
ATOM   106  N  N   . ASP A 1 15  ? -14.796 -28.732 12.783  1.00 10.76 ?  16   ASP A N   1 
ATOM   107  C  CA  . ASP A 1 15  ? -15.704 -29.695 13.402  1.00 12.21 ?  16   ASP A CA  1 
ATOM   108  C  C   . ASP A 1 15  ? -15.814 -29.341 14.879  1.00 13.89 ?  16   ASP A C   1 
ATOM   109  O  O   . ASP A 1 15  ? -14.818 -29.396 15.605  1.00 15.88 ?  16   ASP A O   1 
ATOM   110  C  CB  . ASP A 1 15  ? -15.172 -31.117 13.213  1.00 13.76 ?  16   ASP A CB  1 
ATOM   111  C  CG  . ASP A 1 15  ? -16.232 -32.180 13.446  1.00 21.72 ?  16   ASP A CG  1 
ATOM   112  O  OD1 . ASP A 1 15  ? -17.363 -31.837 13.838  1.00 20.61 ?  16   ASP A OD1 1 
ATOM   113  O  OD2 . ASP A 1 15  ? -15.935 -33.372 13.214  1.00 23.07 -1 16   ASP A OD2 1 
ATOM   114  N  N   . LEU A 1 16  ? -17.023 -28.955 15.322  1.00 12.93 ?  17   LEU A N   1 
ATOM   115  C  CA  . LEU A 1 16  ? -17.320 -28.520 16.684  1.00 13.18 ?  17   LEU A CA  1 
ATOM   116  C  C   . LEU A 1 16  ? -18.110 -29.604 17.422  1.00 13.36 ?  17   LEU A C   1 
ATOM   117  O  O   . LEU A 1 16  ? -18.802 -30.407 16.794  1.00 14.95 ?  17   LEU A O   1 
ATOM   118  C  CB  . LEU A 1 16  ? -18.153 -27.228 16.645  1.00 15.35 ?  17   LEU A CB  1 
ATOM   119  C  CG  . LEU A 1 16  ? -17.477 -25.977 16.064  1.00 15.04 ?  17   LEU A CG  1 
ATOM   120  C  CD1 . LEU A 1 16  ? -18.436 -24.784 16.010  1.00 18.90 ?  17   LEU A CD1 1 
ATOM   121  C  CD2 . LEU A 1 16  ? -16.235 -25.632 16.847  1.00 20.94 ?  17   LEU A CD2 1 
ATOM   122  N  N   . PRO A 1 17  ? -18.042 -29.654 18.752  1.00 16.37 ?  18   PRO A N   1 
ATOM   123  C  CA  . PRO A 1 17  ? -18.680 -30.760 19.493  1.00 14.30 ?  18   PRO A CA  1 
ATOM   124  C  C   . PRO A 1 17  ? -20.198 -30.634 19.475  1.00 16.80 ?  18   PRO A C   1 
ATOM   125  O  O   . PRO A 1 17  ? -20.747 -29.620 19.903  1.00 16.77 ?  18   PRO A O   1 
ATOM   126  C  CB  . PRO A 1 17  ? -18.127 -30.593 20.915  1.00 19.77 ?  18   PRO A CB  1 
ATOM   127  C  CG  . PRO A 1 17  ? -16.927 -29.697 20.770  1.00 24.40 ?  18   PRO A CG  1 
ATOM   128  C  CD  . PRO A 1 17  ? -17.265 -28.778 19.643  1.00 22.94 ?  18   PRO A CD  1 
ATOM   129  N  N   . ASP A 1 18  ? -20.881 -31.685 19.001  1.00 18.18 ?  19   ASP A N   1 
ATOM   130  C  CA  . ASP A 1 18  ? -22.341 -31.651 18.903  1.00 21.40 ?  19   ASP A CA  1 
ATOM   131  C  C   . ASP A 1 18  ? -22.997 -31.361 20.249  1.00 19.31 ?  19   ASP A C   1 
ATOM   132  O  O   . ASP A 1 18  ? -23.946 -30.571 20.330  1.00 24.30 ?  19   ASP A O   1 
ATOM   133  C  CB  . ASP A 1 18  ? -22.862 -32.982 18.361  1.00 25.09 ?  19   ASP A CB  1 
ATOM   134  C  CG  . ASP A 1 18  ? -22.216 -33.372 17.050  1.00 34.50 ?  19   ASP A CG  1 
ATOM   135  O  OD1 . ASP A 1 18  ? -22.139 -32.507 16.160  1.00 30.46 ?  19   ASP A OD1 1 
ATOM   136  O  OD2 . ASP A 1 18  ? -21.791 -34.539 16.908  1.00 47.93 -1 19   ASP A OD2 1 
ATOM   137  N  N   . ASP A 1 19  ? -22.502 -31.987 21.317  1.00 16.45 ?  20   ASP A N   1 
ATOM   138  C  CA  . ASP A 1 19  ? -23.146 -31.892 22.622  1.00 20.11 ?  20   ASP A CA  1 
ATOM   139  C  C   . ASP A 1 19  ? -23.020 -30.507 23.247  1.00 19.00 ?  20   ASP A C   1 
ATOM   140  O  O   . ASP A 1 19  ? -23.780 -30.183 24.166  1.00 19.08 ?  20   ASP A O   1 
ATOM   141  C  CB  . ASP A 1 19  ? -22.577 -32.981 23.541  1.00 18.58 ?  20   ASP A CB  1 
ATOM   142  C  CG  . ASP A 1 19  ? -23.064 -32.857 24.974  1.00 30.30 ?  20   ASP A CG  1 
ATOM   143  O  OD1 . ASP A 1 19  ? -24.269 -33.106 25.206  1.00 29.20 ?  20   ASP A OD1 1 
ATOM   144  O  OD2 . ASP A 1 19  ? -22.241 -32.550 25.869  1.00 30.23 -1 20   ASP A OD2 1 
ATOM   145  N  N   . ARG A 1 20  ? -22.100 -29.673 22.756  1.00 16.11 ?  21   ARG A N   1 
ATOM   146  C  CA  . ARG A 1 20  ? -21.795 -28.397 23.383  1.00 13.19 ?  21   ARG A CA  1 
ATOM   147  C  C   . ARG A 1 20  ? -22.214 -27.180 22.564  1.00 12.76 ?  21   ARG A C   1 
ATOM   148  O  O   . ARG A 1 20  ? -22.154 -26.060 23.087  1.00 13.82 ?  21   ARG A O   1 
ATOM   149  C  CB  . ARG A 1 20  ? -20.284 -28.288 23.663  1.00 14.39 ?  21   ARG A CB  1 
ATOM   150  C  CG  . ARG A 1 20  ? -19.601 -29.517 24.291  1.00 16.75 ?  21   ARG A CG  1 
ATOM   151  C  CD  . ARG A 1 20  ? -20.065 -29.822 25.699  1.00 16.43 ?  21   ARG A CD  1 
ATOM   152  N  NE  . ARG A 1 20  ? -19.912 -28.697 26.617  1.00 14.80 ?  21   ARG A NE  1 
ATOM   153  C  CZ  . ARG A 1 20  ? -18.880 -28.526 27.442  1.00 14.60 ?  21   ARG A CZ  1 
ATOM   154  N  NH1 . ARG A 1 20  ? -17.865 -29.382 27.431  1.00 16.50 ?  21   ARG A NH1 1 
ATOM   155  N  NH2 . ARG A 1 20  ? -18.850 -27.482 28.265  1.00 12.68 ?  21   ARG A NH2 1 
ATOM   156  N  N   . THR A 1 21  ? -22.644 -27.358 21.317  1.00 12.34 ?  22   THR A N   1 
ATOM   157  C  CA  . THR A 1 21  ? -22.713 -26.269 20.348  1.00 13.13 ?  22   THR A CA  1 
ATOM   158  C  C   . THR A 1 21  ? -24.149 -26.020 19.909  1.00 16.19 ?  22   THR A C   1 
ATOM   159  O  O   . THR A 1 21  ? -24.861 -26.957 19.530  1.00 17.89 ?  22   THR A O   1 
ATOM   160  C  CB  . THR A 1 21  ? -21.858 -26.592 19.118  1.00 12.02 ?  22   THR A CB  1 
ATOM   161  O  OG1 . THR A 1 21  ? -20.516 -26.887 19.522  1.00 14.70 ?  22   THR A OG1 1 
ATOM   162  C  CG2 . THR A 1 21  ? -21.839 -25.403 18.160  1.00 16.50 ?  22   THR A CG2 1 
ATOM   163  N  N   . LEU A 1 22  ? -24.553 -24.752 19.928  1.00 13.93 ?  23   LEU A N   1 
ATOM   164  C  CA  . LEU A 1 22  ? -25.871 -24.324 19.473  1.00 14.75 ?  23   LEU A CA  1 
ATOM   165  C  C   . LEU A 1 22  ? -25.935 -24.366 17.944  1.00 12.28 ?  23   LEU A C   1 
ATOM   166  O  O   . LEU A 1 22  ? -24.902 -24.373 17.271  1.00 12.87 ?  23   LEU A O   1 
ATOM   167  C  CB  . LEU A 1 22  ? -26.098 -22.882 19.921  1.00 15.11 ?  23   LEU A CB  1 
ATOM   168  C  CG  . LEU A 1 22  ? -26.649 -22.622 21.322  1.00 20.38 ?  23   LEU A CG  1 
ATOM   169  C  CD1 . LEU A 1 22  ? -25.609 -22.939 22.374  1.00 24.12 ?  23   LEU A CD1 1 
ATOM   170  C  CD2 . LEU A 1 22  ? -27.047 -21.160 21.430  1.00 22.94 ?  23   LEU A CD2 1 
ATOM   171  N  N   . PRO A 1 23  ? -27.134 -24.369 17.366  1.00 16.63 ?  24   PRO A N   1 
ATOM   172  C  CA  . PRO A 1 23  ? -27.243 -24.278 15.904  1.00 16.59 ?  24   PRO A CA  1 
ATOM   173  C  C   . PRO A 1 23  ? -26.591 -23.003 15.400  1.00 12.87 ?  24   PRO A C   1 
ATOM   174  O  O   . PRO A 1 23  ? -26.700 -21.952 16.046  1.00 14.22 ?  24   PRO A O   1 
ATOM   175  C  CB  . PRO A 1 23  ? -28.761 -24.249 15.666  1.00 19.95 ?  24   PRO A CB  1 
ATOM   176  C  CG  . PRO A 1 23  ? -29.340 -24.921 16.883  1.00 19.32 ?  24   PRO A CG  1 
ATOM   177  C  CD  . PRO A 1 23  ? -28.458 -24.469 18.011  1.00 18.79 ?  24   PRO A CD  1 
ATOM   178  N  N   . PRO A 1 24  ? -25.895 -23.056 14.264  1.00 13.21 ?  25   PRO A N   1 
ATOM   179  C  CA  . PRO A 1 24  ? -25.155 -21.872 13.795  1.00 12.22 ?  25   PRO A CA  1 
ATOM   180  C  C   . PRO A 1 24  ? -26.061 -20.676 13.543  1.00 15.10 ?  25   PRO A C   1 
ATOM   181  O  O   . PRO A 1 24  ? -27.210 -20.807 13.108  1.00 14.37 ?  25   PRO A O   1 
ATOM   182  C  CB  . PRO A 1 24  ? -24.496 -22.348 12.496  1.00 14.19 ?  25   PRO A CB  1 
ATOM   183  C  CG  . PRO A 1 24  ? -24.484 -23.859 12.602  1.00 20.16 ?  25   PRO A CG  1 
ATOM   184  C  CD  . PRO A 1 24  ? -25.741 -24.200 13.350  1.00 16.58 ?  25   PRO A CD  1 
ATOM   185  N  N   . LEU A 1 25  ? -25.517 -19.493 13.817  1.00 11.37 ?  26   LEU A N   1 
ATOM   186  C  CA  . LEU A 1 25  ? -26.216 -18.234 13.591  1.00 12.46 ?  26   LEU A CA  1 
ATOM   187  C  C   . LEU A 1 25  ? -25.950 -17.794 12.159  1.00 12.00 ?  26   LEU A C   1 
ATOM   188  O  O   . LEU A 1 25  ? -24.794 -17.567 11.789  1.00 12.25 ?  26   LEU A O   1 
ATOM   189  C  CB  . LEU A 1 25  ? -25.680 -17.182 14.556  1.00 11.35 ?  26   LEU A CB  1 
ATOM   190  C  CG  . LEU A 1 25  ? -26.203 -17.291 15.989  1.00 13.52 ?  26   LEU A CG  1 
ATOM   191  C  CD1 . LEU A 1 25  ? -25.513 -18.406 16.753  1.00 18.93 ?  26   LEU A CD1 1 
ATOM   192  C  CD2 . LEU A 1 25  ? -25.972 -15.981 16.703  1.00 17.26 ?  26   LEU A CD2 1 
ATOM   193  N  N   . THR A 1 26  ? -27.014 -17.678 11.359  1.00 12.12 ?  27   THR A N   1 
ATOM   194  C  CA  . THR A 1 26  ? -26.908 -17.370 9.937   1.00 11.12 ?  27   THR A CA  1 
ATOM   195  C  C   . THR A 1 26  ? -27.927 -16.315 9.530   1.00 15.15 ?  27   THR A C   1 
ATOM   196  O  O   . THR A 1 26  ? -28.970 -16.147 10.165  1.00 15.78 ?  27   THR A O   1 
ATOM   197  C  CB  . THR A 1 26  ? -27.180 -18.614 9.083   1.00 16.27 ?  27   THR A CB  1 
ATOM   198  O  OG1 . THR A 1 26  ? -28.505 -19.084 9.359   1.00 19.76 ?  27   THR A OG1 1 
ATOM   199  C  CG2 . THR A 1 26  ? -26.186 -19.724 9.392   1.00 16.44 ?  27   THR A CG2 1 
ATOM   200  N  N   . ILE A 1 27  ? -27.614 -15.644 8.415   1.00 14.37 ?  28   ILE A N   1 
ATOM   201  C  CA  . ILE A 1 27  ? -28.541 -14.715 7.777   1.00 16.73 ?  28   ILE A CA  1 
ATOM   202  C  C   . ILE A 1 27  ? -29.806 -15.461 7.359   1.00 15.85 ?  28   ILE A C   1 
ATOM   203  O  O   . ILE A 1 27  ? -29.745 -16.580 6.829   1.00 17.63 ?  28   ILE A O   1 
ATOM   204  C  CB  . ILE A 1 27  ? -27.829 -14.089 6.561   1.00 14.68 ?  28   ILE A CB  1 
ATOM   205  C  CG1 . ILE A 1 27  ? -26.602 -13.271 7.013   1.00 17.30 ?  28   ILE A CG1 1 
ATOM   206  C  CG2 . ILE A 1 27  ? -28.783 -13.275 5.699   1.00 21.61 ?  28   ILE A CG2 1 
ATOM   207  C  CD1 . ILE A 1 27  ? -25.512 -13.091 5.928   1.00 20.01 ?  28   ILE A CD1 1 
ATOM   208  N  N   . ARG A 1 28  ? -30.963 -14.845 7.599   1.00 13.90 ?  29   ARG A N   1 
ATOM   209  C  CA  . ARG A 1 28  ? -32.230 -15.478 7.249   1.00 12.86 ?  29   ARG A CA  1 
ATOM   210  C  C   . ARG A 1 28  ? -32.384 -15.576 5.731   1.00 13.36 ?  29   ARG A C   1 
ATOM   211  O  O   . ARG A 1 28  ? -31.892 -14.726 4.986   1.00 12.42 ?  29   ARG A O   1 
ATOM   212  C  CB  . ARG A 1 28  ? -33.402 -14.695 7.837   1.00 16.59 ?  29   ARG A CB  1 
ATOM   213  C  CG  . ARG A 1 28  ? -33.476 -14.741 9.366   1.00 24.24 ?  29   ARG A CG  1 
ATOM   214  C  CD  . ARG A 1 28  ? -34.673 -13.961 9.913   1.00 27.41 ?  29   ARG A CD  1 
ATOM   215  N  N   . PRO A 1 29  ? -33.060 -16.611 5.242   1.00 13.34 ?  30   PRO A N   1 
ATOM   216  C  CA  . PRO A 1 29  ? -33.246 -16.729 3.797   1.00 15.59 ?  30   PRO A CA  1 
ATOM   217  C  C   . PRO A 1 29  ? -34.139 -15.619 3.270   1.00 16.32 ?  30   PRO A C   1 
ATOM   218  O  O   . PRO A 1 29  ? -35.120 -15.213 3.899   1.00 17.71 ?  30   PRO A O   1 
ATOM   219  C  CB  . PRO A 1 29  ? -33.885 -18.114 3.626   1.00 18.74 ?  30   PRO A CB  1 
ATOM   220  C  CG  . PRO A 1 29  ? -34.523 -18.404 4.928   1.00 20.42 ?  30   PRO A CG  1 
ATOM   221  C  CD  . PRO A 1 29  ? -33.666 -17.737 5.973   1.00 13.72 ?  30   PRO A CD  1 
ATOM   222  N  N   . ALA A 1 30  ? -33.735 -15.085 2.129   1.00 12.43 ?  31   ALA A N   1 
ATOM   223  C  CA  . ALA A 1 30  ? -34.536 -14.196 1.312   1.00 12.26 ?  31   ALA A CA  1 
ATOM   224  C  C   . ALA A 1 30  ? -34.187 -14.549 -0.121  1.00 9.45  ?  31   ALA A C   1 
ATOM   225  O  O   . ALA A 1 30  ? -33.059 -14.981 -0.388  1.00 11.05 ?  31   ALA A O   1 
ATOM   226  C  CB  . ALA A 1 30  ? -34.178 -12.728 1.592   1.00 11.51 ?  31   ALA A CB  1 
ATOM   227  N  N   . PRO A 1 31  ? -35.119 -14.415 -1.052  1.00 9.00  ?  32   PRO A N   1 
ATOM   228  C  CA  . PRO A 1 31  ? -34.813 -14.798 -2.438  1.00 9.94  ?  32   PRO A CA  1 
ATOM   229  C  C   . PRO A 1 31  ? -33.779 -13.866 -3.036  1.00 9.93  ?  32   PRO A C   1 
ATOM   230  O  O   . PRO A 1 31  ? -33.951 -12.637 -2.987  1.00 10.38 ?  32   PRO A O   1 
ATOM   231  C  CB  . PRO A 1 31  ? -36.158 -14.660 -3.168  1.00 11.27 ?  32   PRO A CB  1 
ATOM   232  C  CG  . PRO A 1 31  ? -37.178 -14.405 -2.133  1.00 17.39 ?  32   PRO A CG  1 
ATOM   233  C  CD  . PRO A 1 31  ? -36.507 -13.952 -0.886  1.00 10.56 ?  32   PRO A CD  1 
ATOM   234  N  N   . PRO A 1 32  ? -32.689 -14.399 -3.592  1.00 8.18  ?  33   PRO A N   1 
ATOM   235  C  CA  . PRO A 1 32  ? -31.812 -13.552 -4.409  1.00 8.61  ?  33   PRO A CA  1 
ATOM   236  C  C   . PRO A 1 32  ? -32.604 -12.928 -5.544  1.00 10.05 ?  33   PRO A C   1 
ATOM   237  O  O   . PRO A 1 32  ? -33.586 -13.492 -6.040  1.00 9.10  ?  33   PRO A O   1 
ATOM   238  C  CB  . PRO A 1 32  ? -30.783 -14.538 -4.971  1.00 10.78 ?  33   PRO A CB  1 
ATOM   239  C  CG  . PRO A 1 32  ? -30.774 -15.655 -3.984  1.00 12.43 ?  33   PRO A CG  1 
ATOM   240  C  CD  . PRO A 1 32  ? -32.215 -15.797 -3.562  1.00 9.68  ?  33   PRO A CD  1 
ATOM   241  N  N   . LEU A 1 33  ? -32.165 -11.751 -5.967  1.00 8.38  ?  34   LEU A N   1 
ATOM   242  C  CA  . LEU A 1 33  ? -32.668 -11.208 -7.216  1.00 8.93  ?  34   LEU A CA  1 
ATOM   243  C  C   . LEU A 1 33  ? -32.072 -12.002 -8.368  1.00 8.82  ?  34   LEU A C   1 
ATOM   244  O  O   . LEU A 1 33  ? -30.858 -12.206 -8.429  1.00 9.49  ?  34   LEU A O   1 
ATOM   245  C  CB  . LEU A 1 33  ? -32.285 -9.736  -7.354  1.00 8.47  ?  34   LEU A CB  1 
ATOM   246  C  CG  . LEU A 1 33  ? -32.738 -8.821  -6.222  1.00 10.68 ?  34   LEU A CG  1 
ATOM   247  C  CD1 . LEU A 1 33  ? -32.515 -7.368  -6.617  1.00 10.56 ?  34   LEU A CD1 1 
ATOM   248  C  CD2 . LEU A 1 33  ? -34.180 -9.043  -5.789  1.00 20.16 ?  34   LEU A CD2 1 
ATOM   249  N  N   . ASP A 1 34  ? -32.928 -12.467 -9.276  1.00 8.86  ?  35   ASP A N   1 
ATOM   250  C  CA  . ASP A 1 34  ? -32.442 -13.233 -10.415 1.00 9.14  ?  35   ASP A CA  1 
ATOM   251  C  C   . ASP A 1 34  ? -31.478 -12.403 -11.261 1.00 9.11  ?  35   ASP A C   1 
ATOM   252  O  O   . ASP A 1 34  ? -30.415 -12.885 -11.670 1.00 10.17 ?  35   ASP A O   1 
ATOM   253  C  CB  . ASP A 1 34  ? -33.628 -13.693 -11.259 1.00 9.02  ?  35   ASP A CB  1 
ATOM   254  C  CG  . ASP A 1 34  ? -33.210 -14.206 -12.610 1.00 8.74  ?  35   ASP A CG  1 
ATOM   255  O  OD1 . ASP A 1 34  ? -32.529 -15.261 -12.677 1.00 9.28  ?  35   ASP A OD1 1 
ATOM   256  O  OD2 . ASP A 1 34  ? -33.565 -13.551 -13.613 1.00 10.86 -1 35   ASP A OD2 1 
ATOM   257  N  N   . ASP A 1 35  ? -31.820 -11.144 -11.520 1.00 9.83  ?  36   ASP A N   1 
ATOM   258  C  CA  . ASP A 1 35  ? -31.025 -10.295 -12.409 1.00 9.11  ?  36   ASP A CA  1 
ATOM   259  C  C   . ASP A 1 35  ? -30.864 -8.947  -11.722 1.00 8.35  ?  36   ASP A C   1 
ATOM   260  O  O   . ASP A 1 35  ? -31.570 -7.981  -12.036 1.00 9.22  ?  36   ASP A O   1 
ATOM   261  C  CB  . ASP A 1 35  ? -31.661 -10.205 -13.797 1.00 8.53  ?  36   ASP A CB  1 
ATOM   262  C  CG  . ASP A 1 35  ? -30.680 -9.730  -14.853 1.00 11.41 ?  36   ASP A CG  1 
ATOM   263  O  OD1 . ASP A 1 35  ? -29.843 -8.853  -14.537 1.00 10.67 ?  36   ASP A OD1 1 
ATOM   264  O  OD2 . ASP A 1 35  ? -30.730 -10.244 -15.992 1.00 12.30 -1 36   ASP A OD2 1 
ATOM   265  N  N   . PRO A 1 36  ? -29.948 -8.851  -10.758 1.00 8.06  ?  37   PRO A N   1 
ATOM   266  C  CA  . PRO A 1 36  ? -29.815 -7.595  -10.014 1.00 8.35  ?  37   PRO A CA  1 
ATOM   267  C  C   . PRO A 1 36  ? -29.410 -6.417  -10.872 1.00 8.18  ?  37   PRO A C   1 
ATOM   268  O  O   . PRO A 1 36  ? -29.836 -5.298  -10.589 1.00 8.92  ?  37   PRO A O   1 
ATOM   269  C  CB  . PRO A 1 36  ? -28.790 -7.932  -8.921  1.00 8.62  ?  37   PRO A CB  1 
ATOM   270  C  CG  . PRO A 1 36  ? -28.040 -9.119  -9.441  1.00 10.73 ?  37   PRO A CG  1 
ATOM   271  C  CD  . PRO A 1 36  ? -29.080 -9.911  -10.213 1.00 8.10  ?  37   PRO A CD  1 
ATOM   272  N  N   . GLU A 1 37  ? -28.629 -6.624  -11.932 1.00 6.92  ?  38   GLU A N   1 
ATOM   273  C  CA  . GLU A 1 37  ? -28.273 -5.501  -12.796 1.00 7.93  ?  38   GLU A CA  1 
ATOM   274  C  C   . GLU A 1 37  ? -29.511 -4.935  -13.491 1.00 9.12  ?  38   GLU A C   1 
ATOM   275  O  O   . GLU A 1 37  ? -29.680 -3.710  -13.599 1.00 8.77  ?  38   GLU A O   1 
ATOM   276  C  CB  . GLU A 1 37  ? -27.228 -5.944  -13.821 1.00 8.93  ?  38   GLU A CB  1 
ATOM   277  C  CG  . GLU A 1 37  ? -26.633 -4.781  -14.597 1.00 10.55 ?  38   GLU A CG  1 
ATOM   278  C  CD  . GLU A 1 37  ? -25.385 -5.148  -15.381 1.00 14.01 ?  38   GLU A CD  1 
ATOM   279  O  OE1 . GLU A 1 37  ? -24.777 -6.207  -15.116 1.00 16.02 ?  38   GLU A OE1 1 
ATOM   280  O  OE2 . GLU A 1 37  ? -25.015 -4.381  -16.286 1.00 14.59 -1 38   GLU A OE2 1 
ATOM   281  N  N   . ALA A 1 38  ? -30.403 -5.818  -13.950 1.00 8.26  ?  39   ALA A N   1 
ATOM   282  C  CA  . ALA A 1 38  ? -31.644 -5.349  -14.549 1.00 8.68  ?  39   ALA A CA  1 
ATOM   283  C  C   . ALA A 1 38  ? -32.508 -4.645  -13.518 1.00 7.74  ?  39   ALA A C   1 
ATOM   284  O  O   . ALA A 1 38  ? -33.223 -3.687  -13.848 1.00 9.32  ?  39   ALA A O   1 
ATOM   285  C  CB  . ALA A 1 38  ? -32.396 -6.526  -15.179 1.00 9.82  ?  39   ALA A CB  1 
ATOM   286  N  N   . GLU A 1 39  ? -32.423 -5.072  -12.255 1.00 8.77  ?  40   GLU A N   1 
ATOM   287  C  CA  . GLU A 1 39  ? -33.151 -4.374  -11.206 1.00 8.62  ?  40   GLU A CA  1 
ATOM   288  C  C   . GLU A 1 39  ? -32.559 -2.993  -10.956 1.00 8.63  ?  40   GLU A C   1 
ATOM   289  O  O   . GLU A 1 39  ? -33.308 -2.032  -10.754 1.00 9.75  ?  40   GLU A O   1 
ATOM   290  C  CB  . GLU A 1 39  ? -33.152 -5.200  -9.922  1.00 8.97  ?  40   GLU A CB  1 
ATOM   291  C  CG  . GLU A 1 39  ? -34.106 -4.684  -8.858  1.00 12.75 ?  40   GLU A CG  1 
ATOM   292  C  CD  . GLU A 1 39  ? -35.531 -4.538  -9.362  1.00 16.37 ?  40   GLU A CD  1 
ATOM   293  O  OE1 . GLU A 1 39  ? -35.952 -5.353  -10.211 1.00 16.16 ?  40   GLU A OE1 1 
ATOM   294  O  OE2 . GLU A 1 39  ? -36.238 -3.633  -8.867  1.00 25.14 -1 40   GLU A OE2 1 
ATOM   295  N  N   . VAL A 1 40  ? -31.226 -2.869  -10.998 1.00 7.54  ?  41   VAL A N   1 
ATOM   296  C  CA  . VAL A 1 40  ? -30.621 -1.540  -10.884 1.00 7.95  ?  41   VAL A CA  1 
ATOM   297  C  C   . VAL A 1 40  ? -31.138 -0.630  -11.991 1.00 7.85  ?  41   VAL A C   1 
ATOM   298  O  O   . VAL A 1 40  ? -31.502 0.524   -11.737 1.00 8.47  ?  41   VAL A O   1 
ATOM   299  C  CB  . VAL A 1 40  ? -29.083 -1.620  -10.883 1.00 7.08  ?  41   VAL A CB  1 
ATOM   300  C  CG1 . VAL A 1 40  ? -28.483 -0.225  -10.925 1.00 8.32  ?  41   VAL A CG1 1 
ATOM   301  C  CG2 . VAL A 1 40  ? -28.549 -2.386  -9.658  1.00 8.31  ?  41   VAL A CG2 1 
ATOM   302  N  N   . VAL A 1 41  ? -31.202 -1.142  -13.227 1.00 7.56  ?  42   VAL A N   1 
ATOM   303  C  CA  . VAL A 1 41  ? -31.737 -0.354  -14.337 1.00 8.59  ?  42   VAL A CA  1 
ATOM   304  C  C   . VAL A 1 41  ? -33.148 0.130   -14.014 1.00 8.13  ?  42   VAL A C   1 
ATOM   305  O  O   . VAL A 1 41  ? -33.465 1.319   -14.159 1.00 8.63  ?  42   VAL A O   1 
ATOM   306  C  CB  . VAL A 1 41  ? -31.694 -1.162  -15.652 1.00 7.47  ?  42   VAL A CB  1 
ATOM   307  C  CG1 . VAL A 1 41  ? -32.487 -0.435  -16.743 1.00 10.07 ?  42   VAL A CG1 1 
ATOM   308  C  CG2 . VAL A 1 41  ? -30.267 -1.401  -16.116 1.00 9.51  ?  42   VAL A CG2 1 
ATOM   309  N  N   . ARG A 1 42  ? -34.012 -0.778  -13.552 1.00 9.05  ?  43   ARG A N   1 
ATOM   310  C  CA  . ARG A 1 42  ? -35.382 -0.392  -13.208 1.00 9.63  ?  43   ARG A CA  1 
ATOM   311  C  C   . ARG A 1 42  ? -35.418 0.656   -12.097 1.00 10.39 ?  43   ARG A C   1 
ATOM   312  O  O   . ARG A 1 42  ? -36.250 1.574   -12.124 1.00 11.81 ?  43   ARG A O   1 
ATOM   313  C  CB  . ARG A 1 42  ? -36.174 -1.634  -12.797 1.00 10.29 ?  43   ARG A CB  1 
ATOM   314  C  CG  . ARG A 1 42  ? -36.580 -2.483  -13.995 1.00 11.16 ?  43   ARG A CG  1 
ATOM   315  C  CD  . ARG A 1 42  ? -37.417 -3.709  -13.597 1.00 11.68 ?  43   ARG A CD  1 
ATOM   316  N  NE  . ARG A 1 42  ? -36.644 -4.798  -12.981 1.00 12.46 ?  43   ARG A NE  1 
ATOM   317  C  CZ  . ARG A 1 42  ? -36.129 -5.835  -13.642 1.00 14.10 ?  43   ARG A CZ  1 
ATOM   318  N  NH1 . ARG A 1 42  ? -36.262 -5.931  -14.958 1.00 15.78 ?  43   ARG A NH1 1 
ATOM   319  N  NH2 . ARG A 1 42  ? -35.464 -6.765  -12.980 1.00 15.61 ?  43   ARG A NH2 1 
ATOM   320  N  N   . CYS A 1 43  ? -34.522 0.549   -11.114 1.00 9.13  ?  44   CYS A N   1 
ATOM   321  C  CA  . CYS A 1 43  ? -34.550 1.462   -9.981  1.00 10.59 ?  44   CYS A CA  1 
ATOM   322  C  C   . CYS A 1 43  ? -34.006 2.832   -10.382 1.00 10.36 ?  44   CYS A C   1 
ATOM   323  O  O   . CYS A 1 43  ? -34.392 3.849   -9.797  1.00 10.35 ?  44   CYS A O   1 
ATOM   324  C  CB  . CYS A 1 43  ? -33.666 0.845   -8.903  1.00 10.41 ?  44   CYS A CB  1 
ATOM   325  S  SG  . CYS A 1 43  ? -34.501 -0.487  -7.988  1.00 14.54 ?  44   CYS A SG  1 
ATOM   326  N  N   . LEU A 1 44  ? -33.111 2.886   -11.375 1.00 9.39  ?  45   LEU A N   1 
ATOM   327  C  CA  A LEU A 1 44  ? -32.632 4.164   -11.895 0.30 9.72  ?  45   LEU A CA  1 
ATOM   328  C  CA  B LEU A 1 44  ? -32.644 4.178   -11.863 0.70 9.70  ?  45   LEU A CA  1 
ATOM   329  C  C   . LEU A 1 44  ? -33.746 4.927   -12.593 1.00 10.37 ?  45   LEU A C   1 
ATOM   330  O  O   . LEU A 1 44  ? -33.751 6.169   -12.595 1.00 9.68  ?  45   LEU A O   1 
ATOM   331  C  CB  A LEU A 1 44  ? -31.506 3.920   -12.900 0.30 8.93  ?  45   LEU A CB  1 
ATOM   332  C  CB  B LEU A 1 44  ? -31.419 4.010   -12.762 0.70 8.72  ?  45   LEU A CB  1 
ATOM   333  C  CG  A LEU A 1 44  ? -30.133 3.554   -12.345 0.30 7.11  ?  45   LEU A CG  1 
ATOM   334  C  CG  B LEU A 1 44  ? -30.069 4.209   -12.075 0.70 7.97  ?  45   LEU A CG  1 
ATOM   335  C  CD1 A LEU A 1 44  ? -29.143 3.364   -13.471 0.30 8.14  ?  45   LEU A CD1 1 
ATOM   336  C  CD1 B LEU A 1 44  ? -29.975 3.425   -10.770 0.70 7.18  ?  45   LEU A CD1 1 
ATOM   337  C  CD2 A LEU A 1 44  ? -29.664 4.626   -11.436 0.30 11.30 ?  45   LEU A CD2 1 
ATOM   338  C  CD2 B LEU A 1 44  ? -28.925 3.842   -13.004 0.70 7.70  ?  45   LEU A CD2 1 
ATOM   339  N  N   . ALA A 1 45  ? -34.688 4.196   -13.202 1.00 10.64 ?  46   ALA A N   1 
ATOM   340  C  CA  . ALA A 1 45  ? -35.815 4.813   -13.885 1.00 10.21 ?  46   ALA A CA  1 
ATOM   341  C  C   . ALA A 1 45  ? -36.918 5.194   -12.913 1.00 11.31 ?  46   ALA A C   1 
ATOM   342  O  O   . ALA A 1 45  ? -37.655 6.153   -13.174 1.00 13.33 ?  46   ALA A O   1 
ATOM   343  C  CB  . ALA A 1 45  ? -36.368 3.851   -14.940 1.00 11.87 ?  46   ALA A CB  1 
ATOM   344  N  N   . GLU A 1 46  ? -37.035 4.484   -11.794 1.00 12.10 ?  47   GLU A N   1 
ATOM   345  C  CA  . GLU A 1 46  ? -38.092 4.727   -10.812 1.00 11.63 ?  47   GLU A CA  1 
ATOM   346  C  C   . GLU A 1 46  ? -37.482 4.651   -9.419  1.00 10.91 ?  47   GLU A C   1 
ATOM   347  O  O   . GLU A 1 46  ? -37.672 3.672   -8.689  1.00 13.99 ?  47   GLU A O   1 
ATOM   348  C  CB  . GLU A 1 46  ? -39.219 3.705   -10.981 1.00 15.14 ?  47   GLU A CB  1 
ATOM   349  C  CG  . GLU A 1 46  ? -40.080 3.962   -12.217 1.00 20.72 ?  47   GLU A CG  1 
ATOM   350  C  CD  . GLU A 1 46  ? -41.264 3.021   -12.335 1.00 36.13 ?  47   GLU A CD  1 
ATOM   351  O  OE1 . GLU A 1 46  ? -42.240 3.384   -13.025 1.00 49.38 ?  47   GLU A OE1 1 
ATOM   352  O  OE2 . GLU A 1 46  ? -41.216 1.916   -11.752 1.00 38.43 -1 47   GLU A OE2 1 
ATOM   353  N  N   . PRO A 1 47  ? -36.728 5.674   -9.023  1.00 10.31 ?  48   PRO A N   1 
ATOM   354  C  CA  . PRO A 1 47  ? -36.015 5.641   -7.741  1.00 9.31  ?  48   PRO A CA  1 
ATOM   355  C  C   . PRO A 1 47  ? -36.891 6.106   -6.581  1.00 11.93 ?  48   PRO A C   1 
ATOM   356  O  O   . PRO A 1 47  ? -38.033 6.527   -6.752  1.00 13.29 ?  48   PRO A O   1 
ATOM   357  C  CB  . PRO A 1 47  ? -34.853 6.610   -7.972  1.00 10.02 ?  48   PRO A CB  1 
ATOM   358  C  CG  . PRO A 1 47  ? -35.391 7.593   -8.933  1.00 12.25 ?  48   PRO A CG  1 
ATOM   359  C  CD  . PRO A 1 47  ? -36.356 6.851   -9.824  1.00 10.85 ?  48   PRO A CD  1 
ATOM   360  N  N   . ILE A 1 48  ? -36.312 6.039   -5.384  1.00 9.92  ?  49   ILE A N   1 
ATOM   361  C  CA  . ILE A 1 48  ? -36.979 6.460   -4.153  1.00 11.65 ?  49   ILE A CA  1 
ATOM   362  C  C   . ILE A 1 48  ? -36.598 7.907   -3.853  1.00 12.52 ?  49   ILE A C   1 
ATOM   363  O  O   . ILE A 1 48  ? -35.419 8.217   -3.664  1.00 12.36 ?  49   ILE A O   1 
ATOM   364  C  CB  . ILE A 1 48  ? -36.583 5.553   -2.979  1.00 15.40 ?  49   ILE A CB  1 
ATOM   365  C  CG1 . ILE A 1 48  ? -36.745 4.075   -3.338  1.00 17.21 ?  49   ILE A CG1 1 
ATOM   366  C  CG2 . ILE A 1 48  ? -37.384 5.941   -1.729  1.00 18.07 ?  49   ILE A CG2 1 
ATOM   367  C  CD1 . ILE A 1 48  ? -35.764 3.191   -2.605  1.00 21.42 ?  49   ILE A CD1 1 
ATOM   368  N  N   . GLY A 1 49  ? -37.591 8.795   -3.804  1.00 12.57 ?  50   GLY A N   1 
ATOM   369  C  CA  . GLY A 1 49  ? -37.363 10.140  -3.302  1.00 12.64 ?  50   GLY A CA  1 
ATOM   370  C  C   . GLY A 1 49  ? -36.507 11.049  -4.159  1.00 10.01 ?  50   GLY A C   1 
ATOM   371  O  O   . GLY A 1 49  ? -35.975 12.036  -3.656  1.00 13.38 ?  50   GLY A O   1 
ATOM   372  N  N   . SER A 1 50  ? -36.368 10.760  -5.443  1.00 11.84 ?  51   SER A N   1 
ATOM   373  C  CA  A SER A 1 50  ? -35.504 11.526  -6.330  0.42 12.06 ?  51   SER A CA  1 
ATOM   374  C  CA  B SER A 1 50  ? -35.543 11.573  -6.319  0.58 12.00 ?  51   SER A CA  1 
ATOM   375  C  C   . SER A 1 50  ? -36.096 11.465  -7.729  1.00 10.49 ?  51   SER A C   1 
ATOM   376  O  O   . SER A 1 50  ? -36.878 10.556  -8.031  1.00 13.05 ?  51   SER A O   1 
ATOM   377  C  CB  A SER A 1 50  ? -34.088 10.928  -6.323  0.42 14.58 ?  51   SER A CB  1 
ATOM   378  C  CB  B SER A 1 50  ? -34.069 11.134  -6.262  0.58 15.05 ?  51   SER A CB  1 
ATOM   379  O  OG  A SER A 1 50  ? -33.381 11.208  -7.516  0.42 12.05 ?  51   SER A OG  1 
ATOM   380  O  OG  B SER A 1 50  ? -33.824 10.013  -7.087  0.58 12.10 ?  51   SER A OG  1 
ATOM   381  N  N   . PRO A 1 51  ? -35.751 12.405  -8.609  1.00 11.08 ?  52   PRO A N   1 
ATOM   382  C  CA  . PRO A 1 51  ? -36.078 12.217  -10.015 1.00 11.84 ?  52   PRO A CA  1 
ATOM   383  C  C   . PRO A 1 51  ? -35.337 11.004  -10.544 1.00 11.49 ?  52   PRO A C   1 
ATOM   384  O  O   . PRO A 1 51  ? -34.334 10.579  -9.944  1.00 9.94  ?  52   PRO A O   1 
ATOM   385  C  CB  . PRO A 1 51  ? -35.560 13.503  -10.688 1.00 13.48 ?  52   PRO A CB  1 
ATOM   386  C  CG  . PRO A 1 51  ? -35.256 14.441  -9.618  1.00 16.91 ?  52   PRO A CG  1 
ATOM   387  C  CD  . PRO A 1 51  ? -35.016 13.665  -8.373  1.00 13.33 ?  52   PRO A CD  1 
ATOM   388  N  N   . PRO A 1 52  ? -35.788 10.434  -11.659 1.00 11.79 ?  53   PRO A N   1 
ATOM   389  C  CA  . PRO A 1 52  ? -34.988 9.414   -12.349 1.00 9.45  ?  53   PRO A CA  1 
ATOM   390  C  C   . PRO A 1 52  ? -33.589 9.959   -12.595 1.00 10.82 ?  53   PRO A C   1 
ATOM   391  O  O   . PRO A 1 52  ? -33.416 11.142  -12.894 1.00 11.39 ?  53   PRO A O   1 
ATOM   392  C  CB  . PRO A 1 52  ? -35.742 9.226   -13.672 1.00 11.52 ?  53   PRO A CB  1 
ATOM   393  C  CG  . PRO A 1 52  ? -37.159 9.609   -13.343 1.00 13.18 ?  53   PRO A CG  1 
ATOM   394  C  CD  . PRO A 1 52  ? -37.005 10.777  -12.415 1.00 11.99 ?  53   PRO A CD  1 
ATOM   395  N  N   . LEU A 1 53  ? -32.581 9.087   -12.472 1.00 10.26 ?  54   LEU A N   1 
ATOM   396  C  CA  . LEU A 1 53  ? -31.198 9.524   -12.672 1.00 10.47 ?  54   LEU A CA  1 
ATOM   397  C  C   . LEU A 1 53  ? -30.995 10.196  -14.032 1.00 10.64 ?  54   LEU A C   1 
ATOM   398  O  O   . LEU A 1 53  ? -30.225 11.157  -14.141 1.00 10.35 ?  54   LEU A O   1 
ATOM   399  C  CB  . LEU A 1 53  ? -30.228 8.351   -12.484 1.00 8.79  ?  54   LEU A CB  1 
ATOM   400  C  CG  . LEU A 1 53  ? -28.743 8.696   -12.662 1.00 8.57  ?  54   LEU A CG  1 
ATOM   401  C  CD1 . LEU A 1 53  ? -28.299 9.781   -11.680 1.00 11.18 ?  54   LEU A CD1 1 
ATOM   402  C  CD2 . LEU A 1 53  ? -27.849 7.458   -12.576 1.00 10.88 ?  54   LEU A CD2 1 
ATOM   403  N  N   . LEU A 1 54  ? -31.685 9.720   -15.074 1.00 10.28 ?  55   LEU A N   1 
ATOM   404  C  CA  . LEU A 1 54  ? -31.544 10.319  -16.401 1.00 9.39  ?  55   LEU A CA  1 
ATOM   405  C  C   . LEU A 1 54  ? -31.903 11.798  -16.381 1.00 12.75 ?  55   LEU A C   1 
ATOM   406  O  O   . LEU A 1 54  ? -31.190 12.632  -16.954 1.00 12.77 ?  55   LEU A O   1 
ATOM   407  C  CB  . LEU A 1 54  ? -32.422 9.571   -17.401 1.00 12.69 ?  55   LEU A CB  1 
ATOM   408  C  CG  . LEU A 1 54  ? -32.470 10.114  -18.834 1.00 13.07 ?  55   LEU A CG  1 
ATOM   409  C  CD1 . LEU A 1 54  ? -31.120 9.972   -19.524 1.00 16.85 ?  55   LEU A CD1 1 
ATOM   410  C  CD2 . LEU A 1 54  ? -33.533 9.369   -19.614 1.00 15.37 ?  55   LEU A CD2 1 
ATOM   411  N  N   . ASP A 1 55  ? -33.004 12.143  -15.716 1.00 12.06 ?  56   ASP A N   1 
ATOM   412  C  CA  . ASP A 1 55  ? -33.434 13.539  -15.676 1.00 13.51 ?  56   ASP A CA  1 
ATOM   413  C  C   . ASP A 1 55  ? -32.529 14.365  -14.769 1.00 13.33 ?  56   ASP A C   1 
ATOM   414  O  O   . ASP A 1 55  ? -32.228 15.528  -15.069 1.00 15.27 ?  56   ASP A O   1 
ATOM   415  C  CB  . ASP A 1 55  ? -34.894 13.591  -15.226 1.00 16.08 ?  56   ASP A CB  1 
ATOM   416  C  CG  . ASP A 1 55  ? -35.816 12.829  -16.171 1.00 19.61 ?  56   ASP A CG  1 
ATOM   417  O  OD1 . ASP A 1 55  ? -35.714 13.036  -17.400 1.00 27.50 ?  56   ASP A OD1 1 
ATOM   418  O  OD2 . ASP A 1 55  ? -36.617 12.007  -15.693 1.00 27.29 -1 56   ASP A OD2 1 
ATOM   419  N  N   . LEU A 1 56  ? -32.085 13.775  -13.658 1.00 13.36 ?  57   LEU A N   1 
ATOM   420  C  CA  A LEU A 1 56  ? -31.140 14.441  -12.769 0.50 17.46 ?  57   LEU A CA  1 
ATOM   421  C  CA  B LEU A 1 56  ? -31.134 14.436  -12.767 0.50 17.47 ?  57   LEU A CA  1 
ATOM   422  C  C   . LEU A 1 56  ? -29.829 14.760  -13.480 1.00 14.91 ?  57   LEU A C   1 
ATOM   423  O  O   . LEU A 1 56  ? -29.211 15.801  -13.224 1.00 18.08 ?  57   LEU A O   1 
ATOM   424  C  CB  A LEU A 1 56  ? -30.883 13.534  -11.566 0.50 39.85 ?  57   LEU A CB  1 
ATOM   425  C  CB  B LEU A 1 56  ? -30.832 13.526  -11.577 0.50 39.85 ?  57   LEU A CB  1 
ATOM   426  C  CG  A LEU A 1 56  ? -30.339 14.109  -10.265 0.50 42.32 ?  57   LEU A CG  1 
ATOM   427  C  CG  B LEU A 1 56  ? -31.482 13.826  -10.234 0.50 41.84 ?  57   LEU A CG  1 
ATOM   428  C  CD1 A LEU A 1 56  ? -31.221 15.235  -9.772  0.50 41.54 ?  57   LEU A CD1 1 
ATOM   429  C  CD1 B LEU A 1 56  ? -31.060 12.776  -9.223  0.50 40.30 ?  57   LEU A CD1 1 
ATOM   430  C  CD2 A LEU A 1 56  ? -30.261 13.000  -9.232  0.50 40.58 ?  57   LEU A CD2 1 
ATOM   431  C  CD2 B LEU A 1 56  ? -31.079 15.211  -9.770  0.50 41.47 ?  57   LEU A CD2 1 
ATOM   432  N  N   . ALA A 1 57  ? -29.384 13.875  -14.367 1.00 11.38 ?  58   ALA A N   1 
ATOM   433  C  CA  . ALA A 1 57  ? -28.075 14.015  -14.986 1.00 10.83 ?  58   ALA A CA  1 
ATOM   434  C  C   . ALA A 1 57  ? -28.069 14.937  -16.198 1.00 11.79 ?  58   ALA A C   1 
ATOM   435  O  O   . ALA A 1 57  ? -27.009 15.454  -16.553 1.00 12.13 ?  58   ALA A O   1 
ATOM   436  C  CB  . ALA A 1 57  ? -27.537 12.638  -15.385 1.00 10.90 ?  58   ALA A CB  1 
ATOM   437  N  N   . ARG A 1 58  ? -29.206 15.143  -16.850 1.00 13.38 ?  59   ARG A N   1 
ATOM   438  C  CA  . ARG A 1 58  ? -29.191 15.901  -18.094 1.00 13.86 ?  59   ARG A CA  1 
ATOM   439  C  C   . ARG A 1 58  ? -28.707 17.330  -17.849 1.00 14.00 ?  59   ARG A C   1 
ATOM   440  O  O   . ARG A 1 58  ? -29.114 17.989  -16.887 1.00 17.06 ?  59   ARG A O   1 
ATOM   441  C  CB  . ARG A 1 58  ? -30.576 15.876  -18.738 1.00 22.79 ?  59   ARG A CB  1 
ATOM   442  C  CG  . ARG A 1 58  ? -30.538 15.955  -20.261 1.00 29.91 ?  59   ARG A CG  1 
ATOM   443  C  CD  . ARG A 1 58  ? -31.936 15.953  -20.873 1.00 36.61 ?  59   ARG A CD  1 
ATOM   444  N  NE  . ARG A 1 58  ? -32.589 14.641  -20.875 1.00 35.50 ?  59   ARG A NE  1 
ATOM   445  C  CZ  . ARG A 1 58  ? -32.254 13.625  -21.668 1.00 37.43 ?  59   ARG A CZ  1 
ATOM   446  N  NH1 . ARG A 1 58  ? -31.257 13.747  -22.537 1.00 41.24 ?  59   ARG A NH1 1 
ATOM   447  N  NH2 . ARG A 1 58  ? -32.924 12.481  -21.600 1.00 33.72 ?  59   ARG A NH2 1 
ATOM   448  N  N   . GLY A 1 59  ? -27.786 17.789  -18.695 1.00 14.60 ?  60   GLY A N   1 
ATOM   449  C  CA  . GLY A 1 59  ? -27.201 19.101  -18.530 1.00 16.50 ?  60   GLY A CA  1 
ATOM   450  C  C   . GLY A 1 59  ? -26.102 19.203  -17.495 1.00 19.44 ?  60   GLY A C   1 
ATOM   451  O  O   . GLY A 1 59  ? -25.518 20.282  -17.344 1.00 23.88 ?  60   GLY A O   1 
ATOM   452  N  N   . LYS A 1 60  ? -25.809 18.135  -16.756 1.00 15.06 ?  61   LYS A N   1 
ATOM   453  C  CA  . LYS A 1 60  ? -24.713 18.175  -15.798 1.00 15.80 ?  61   LYS A CA  1 
ATOM   454  C  C   . LYS A 1 60  ? -23.390 18.020  -16.536 1.00 16.37 ?  61   LYS A C   1 
ATOM   455  O  O   . LYS A 1 60  ? -23.261 17.195  -17.444 1.00 18.73 ?  61   LYS A O   1 
ATOM   456  C  CB  . LYS A 1 60  ? -24.879 17.060  -14.767 1.00 14.70 ?  61   LYS A CB  1 
ATOM   457  C  CG  . LYS A 1 60  ? -26.122 17.206  -13.905 1.00 14.61 ?  61   LYS A CG  1 
ATOM   458  C  CD  . LYS A 1 60  ? -26.032 18.397  -12.957 1.00 18.70 ?  61   LYS A CD  1 
ATOM   459  C  CE  . LYS A 1 60  ? -27.258 18.501  -12.062 1.00 21.78 ?  61   LYS A CE  1 
ATOM   460  N  NZ  . LYS A 1 60  ? -28.538 18.546  -12.804 1.00 26.03 ?  61   LYS A NZ  1 
ATOM   461  N  N   . ARG A 1 61  ? -22.410 18.839  -16.163 1.00 16.38 ?  62   ARG A N   1 
ATOM   462  C  CA  . ARG A 1 61  ? -21.159 18.904  -16.906 1.00 18.87 ?  62   ARG A CA  1 
ATOM   463  C  C   . ARG A 1 61  ? -20.116 17.915  -16.415 1.00 16.31 ?  62   ARG A C   1 
ATOM   464  O  O   . ARG A 1 61  ? -19.194 17.579  -17.164 1.00 19.21 ?  62   ARG A O   1 
ATOM   465  C  CB  . ARG A 1 61  ? -20.570 20.312  -16.813 1.00 20.69 ?  62   ARG A CB  1 
ATOM   466  N  N   . SER A 1 62  ? -20.229 17.456  -15.177 1.00 11.73 ?  63   SER A N   1 
ATOM   467  C  CA  . SER A 1 62  ? -19.239 16.571  -14.596 1.00 12.70 ?  63   SER A CA  1 
ATOM   468  C  C   . SER A 1 62  ? -19.960 15.705  -13.583 1.00 12.57 ?  63   SER A C   1 
ATOM   469  O  O   . SER A 1 62  ? -20.968 16.115  -13.003 1.00 13.17 ?  63   SER A O   1 
ATOM   470  C  CB  . SER A 1 62  ? -18.119 17.354  -13.896 1.00 13.46 ?  63   SER A CB  1 
ATOM   471  O  OG  . SER A 1 62  ? -18.639 18.221  -12.900 1.00 15.94 ?  63   SER A OG  1 
ATOM   472  N  N   . ALA A 1 63  ? -19.436 14.505  -13.379 1.00 9.32  ?  64   ALA A N   1 
ATOM   473  C  CA  . ALA A 1 63  ? -19.997 13.583  -12.406 1.00 9.00  ?  64   ALA A CA  1 
ATOM   474  C  C   . ALA A 1 63  ? -18.867 12.952  -11.614 1.00 9.46  ?  64   ALA A C   1 
ATOM   475  O  O   . ALA A 1 63  ? -17.786 12.684  -12.151 1.00 10.02 ?  64   ALA A O   1 
ATOM   476  C  CB  . ALA A 1 63  ? -20.809 12.479  -13.082 1.00 10.51 ?  64   ALA A CB  1 
ATOM   477  N  N   . CYS A 1 64  ? -19.127 12.699  -10.336 1.00 7.62  ?  65   CYS A N   1 
ATOM   478  C  CA  . CYS A 1 64  ? -18.197 11.935  -9.519  1.00 7.82  ?  65   CYS A CA  1 
ATOM   479  C  C   . CYS A 1 64  ? -18.996 10.818  -8.871  1.00 7.05  ?  65   CYS A C   1 
ATOM   480  O  O   . CYS A 1 64  ? -19.989 11.088  -8.184  1.00 8.71  ?  65   CYS A O   1 
ATOM   481  C  CB  . CYS A 1 64  ? -17.549 12.825  -8.458  1.00 8.21  ?  65   CYS A CB  1 
ATOM   482  S  SG  . CYS A 1 64  ? -16.435 11.949  -7.358  1.00 9.26  ?  65   CYS A SG  1 
ATOM   483  N  N   . ILE A 1 65  ? -18.579 9.571   -9.113  1.00 6.40  ?  66   ILE A N   1 
ATOM   484  C  CA  . ILE A 1 65  ? -19.223 8.378   -8.569  1.00 6.85  ?  66   ILE A CA  1 
ATOM   485  C  C   . ILE A 1 65  ? -18.320 7.802   -7.488  1.00 7.40  ?  66   ILE A C   1 
ATOM   486  O  O   . ILE A 1 65  ? -17.199 7.360   -7.783  1.00 7.74  ?  66   ILE A O   1 
ATOM   487  C  CB  . ILE A 1 65  ? -19.458 7.310   -9.647  1.00 6.27  ?  66   ILE A CB  1 
ATOM   488  C  CG1 . ILE A 1 65  ? -20.245 7.881   -10.839 1.00 8.29  ?  66   ILE A CG1 1 
ATOM   489  C  CG2 . ILE A 1 65  ? -20.179 6.113   -9.037  1.00 8.06  ?  66   ILE A CG2 1 
ATOM   490  C  CD1 . ILE A 1 65  ? -20.236 6.984   -12.054 1.00 9.16  ?  66   ILE A CD1 1 
ATOM   491  N  N   . LEU A 1 66  ? -18.820 7.764   -6.253  1.00 6.52  ?  67   LEU A N   1 
ATOM   492  C  CA  . LEU A 1 66  ? -18.074 7.165   -5.152  1.00 6.56  ?  67   LEU A CA  1 
ATOM   493  C  C   . LEU A 1 66  ? -18.268 5.657   -5.151  1.00 7.77  ?  67   LEU A C   1 
ATOM   494  O  O   . LEU A 1 66  ? -19.398 5.175   -5.252  1.00 7.39  ?  67   LEU A O   1 
ATOM   495  C  CB  . LEU A 1 66  ? -18.554 7.728   -3.813  1.00 7.68  ?  67   LEU A CB  1 
ATOM   496  C  CG  . LEU A 1 66  ? -18.484 9.244   -3.688  1.00 6.52  ?  67   LEU A CG  1 
ATOM   497  C  CD1 . LEU A 1 66  ? -18.872 9.706   -2.278  1.00 8.26  ?  67   LEU A CD1 1 
ATOM   498  C  CD2 . LEU A 1 66  ? -17.091 9.750   -4.089  1.00 7.93  ?  67   LEU A CD2 1 
ATOM   499  N  N   . VAL A 1 67  ? -17.162 4.921   -5.042  1.00 6.74  ?  68   VAL A N   1 
ATOM   500  C  CA  . VAL A 1 67  ? -17.198 3.468   -4.900  1.00 6.11  ?  68   VAL A CA  1 
ATOM   501  C  C   . VAL A 1 67  ? -16.406 3.061   -3.672  1.00 6.06  ?  68   VAL A C   1 
ATOM   502  O  O   . VAL A 1 67  ? -15.481 3.761   -3.249  1.00 7.26  ?  68   VAL A O   1 
ATOM   503  C  CB  . VAL A 1 67  ? -16.637 2.729   -6.134  1.00 7.02  ?  68   VAL A CB  1 
ATOM   504  C  CG1 . VAL A 1 67  ? -17.448 3.036   -7.381  1.00 8.81  ?  68   VAL A CG1 1 
ATOM   505  C  CG2 . VAL A 1 67  ? -15.146 3.075   -6.345  1.00 8.60  ?  68   VAL A CG2 1 
ATOM   506  N  N   . CYS A 1 68  ? -16.762 1.917   -3.103  1.00 6.28  ?  69   CYS A N   1 
ATOM   507  C  CA  . CYS A 1 68  ? -16.026 1.412   -1.955  1.00 6.90  ?  69   CYS A CA  1 
ATOM   508  C  C   . CYS A 1 68  ? -14.683 0.836   -2.394  1.00 7.56  ?  69   CYS A C   1 
ATOM   509  O  O   . CYS A 1 68  ? -14.497 0.443   -3.550  1.00 8.04  ?  69   CYS A O   1 
ATOM   510  C  CB  . CYS A 1 68  ? -16.827 0.306   -1.288  1.00 7.30  ?  69   CYS A CB  1 
ATOM   511  S  SG  . CYS A 1 68  ? -18.349 0.880   -0.488  1.00 8.83  ?  69   CYS A SG  1 
ATOM   512  N  N   . ASP A 1 69  ? -13.752 0.757   -1.442  1.00 6.72  ?  70   ASP A N   1 
ATOM   513  C  CA  . ASP A 1 69  ? -12.450 0.150   -1.707  1.00 7.05  ?  70   ASP A CA  1 
ATOM   514  C  C   . ASP A 1 69  ? -12.512 -1.376  -1.585  1.00 6.82  ?  70   ASP A C   1 
ATOM   515  O  O   . ASP A 1 69  ? -13.584 -1.986  -1.516  1.00 7.53  ?  70   ASP A O   1 
ATOM   516  C  CB  . ASP A 1 69  ? -11.368 0.813   -0.856  1.00 7.88  ?  70   ASP A CB  1 
ATOM   517  C  CG  . ASP A 1 69  ? -11.477 0.484   0.634   1.00 7.74  ?  70   ASP A CG  1 
ATOM   518  O  OD1 . ASP A 1 69  ? -12.399 -0.258  1.050   1.00 8.23  ?  70   ASP A OD1 1 
ATOM   519  O  OD2 . ASP A 1 69  ? -10.611 0.989   1.383   1.00 9.04  -1 70   ASP A OD2 1 
ATOM   520  N  N   . ILE A 1 70  ? -11.337 -2.015  -1.555  1.00 6.45  ?  71   ILE A N   1 
ATOM   521  C  CA  . ILE A 1 70  ? -11.276 -3.472  -1.652  1.00 7.77  ?  71   ILE A CA  1 
ATOM   522  C  C   . ILE A 1 70  ? -11.971 -4.141  -0.483  1.00 8.50  ?  71   ILE A C   1 
ATOM   523  O  O   . ILE A 1 70  ? -12.428 -5.283  -0.609  1.00 8.51  ?  71   ILE A O   1 
ATOM   524  C  CB  . ILE A 1 70  ? -9.816  -3.954  -1.785  1.00 8.42  ?  71   ILE A CB  1 
ATOM   525  C  CG1 . ILE A 1 70  ? -9.730  -5.390  -2.338  1.00 9.93  ?  71   ILE A CG1 1 
ATOM   526  C  CG2 . ILE A 1 70  ? -9.095  -3.867  -0.450  1.00 8.89  ?  71   ILE A CG2 1 
ATOM   527  C  CD1 . ILE A 1 70  ? -10.397 -5.590  -3.688  1.00 11.46 ?  71   ILE A CD1 1 
ATOM   528  N  N   . THR A 1 71  ? -12.043 -3.468  0.672   1.00 7.48  ?  72   THR A N   1 
ATOM   529  C  CA  . THR A 1 71  ? -12.524 -4.109  1.894   1.00 7.62  ?  72   THR A CA  1 
ATOM   530  C  C   . THR A 1 71  ? -14.018 -4.398  1.872   1.00 8.61  ?  72   THR A C   1 
ATOM   531  O  O   . THR A 1 71  ? -14.509 -5.097  2.774   1.00 9.02  ?  72   THR A O   1 
ATOM   532  C  CB  . THR A 1 71  ? -12.187 -3.264  3.130   1.00 7.00  ?  72   THR A CB  1 
ATOM   533  O  OG1 . THR A 1 71  ? -13.027 -2.100  3.169   1.00 7.69  ?  72   THR A OG1 1 
ATOM   534  C  CG2 . THR A 1 71  ? -10.717 -2.838  3.152   1.00 8.39  ?  72   THR A CG2 1 
ATOM   535  N  N   . ARG A 1 72  ? -14.746 -3.859  0.895   1.00 7.00  ?  73   ARG A N   1 
ATOM   536  C  CA  . ARG A 1 72  ? -16.180 -4.078  0.786   1.00 7.86  ?  73   ARG A CA  1 
ATOM   537  C  C   . ARG A 1 72  ? -16.439 -4.888  -0.467  1.00 7.99  ?  73   ARG A C   1 
ATOM   538  O  O   . ARG A 1 72  ? -16.090 -4.428  -1.566  1.00 9.55  ?  73   ARG A O   1 
ATOM   539  C  CB  . ARG A 1 72  ? -16.931 -2.744  0.704   1.00 7.90  ?  73   ARG A CB  1 
ATOM   540  C  CG  . ARG A 1 72  ? -16.478 -1.687  1.716   1.00 8.48  ?  73   ARG A CG  1 
ATOM   541  C  CD  . ARG A 1 72  ? -16.561 -2.219  3.136   1.00 8.76  ?  73   ARG A CD  1 
ATOM   542  N  NE  . ARG A 1 72  ? -16.817 -1.193  4.140   1.00 7.93  ?  73   ARG A NE  1 
ATOM   543  C  CZ  . ARG A 1 72  ? -16.035 -0.950  5.187   1.00 7.14  ?  73   ARG A CZ  1 
ATOM   544  N  NH1 . ARG A 1 72  ? -14.872 -1.575  5.333   1.00 6.91  ?  73   ARG A NH1 1 
ATOM   545  N  NH2 . ARG A 1 72  ? -16.412 -0.058  6.086   1.00 7.95  ?  73   ARG A NH2 1 
ATOM   546  N  N   . PRO A 1 73  ? -17.055 -6.057  -0.375  1.00 7.23  ?  74   PRO A N   1 
ATOM   547  C  CA  . PRO A 1 73  ? -17.311 -6.882  -1.564  1.00 7.66  ?  74   PRO A CA  1 
ATOM   548  C  C   . PRO A 1 73  ? -18.513 -6.424  -2.385  1.00 9.28  ?  74   PRO A C   1 
ATOM   549  O  O   . PRO A 1 73  ? -19.425 -7.203  -2.675  1.00 10.49 ?  74   PRO A O   1 
ATOM   550  C  CB  . PRO A 1 73  ? -17.545 -8.273  -0.966  1.00 9.06  ?  74   PRO A CB  1 
ATOM   551  C  CG  . PRO A 1 73  ? -18.164 -7.980  0.365   1.00 9.33  ?  74   PRO A CG  1 
ATOM   552  C  CD  . PRO A 1 73  ? -17.491 -6.723  0.867   1.00 7.76  ?  74   PRO A CD  1 
ATOM   553  N  N   . VAL A 1 74  ? -18.517 -5.152  -2.758  1.00 8.88  ?  75   VAL A N   1 
ATOM   554  C  CA  . VAL A 1 74  ? -19.586 -4.633  -3.617  1.00 8.41  ?  75   VAL A CA  1 
ATOM   555  C  C   . VAL A 1 74  ? -19.402 -5.204  -5.015  1.00 8.80  ?  75   VAL A C   1 
ATOM   556  O  O   . VAL A 1 74  ? -18.292 -5.119  -5.565  1.00 8.89  ?  75   VAL A O   1 
ATOM   557  C  CB  . VAL A 1 74  ? -19.537 -3.101  -3.667  1.00 7.64  ?  75   VAL A CB  1 
ATOM   558  C  CG1 . VAL A 1 74  ? -20.804 -2.569  -4.349  1.00 9.69  ?  75   VAL A CG1 1 
ATOM   559  C  CG2 . VAL A 1 74  ? -19.383 -2.491  -2.283  1.00 9.22  ?  75   VAL A CG2 1 
ATOM   560  N  N   . PRO A 1 75  ? -20.439 -5.779  -5.632  1.00 9.22  ?  76   PRO A N   1 
ATOM   561  C  CA  . PRO A 1 75  ? -20.317 -6.208  -7.039  1.00 8.32  ?  76   PRO A CA  1 
ATOM   562  C  C   . PRO A 1 75  ? -20.449 -4.990  -7.940  1.00 9.42  ?  76   PRO A C   1 
ATOM   563  O  O   . PRO A 1 75  ? -21.460 -4.773  -8.611  1.00 10.26 ?  76   PRO A O   1 
ATOM   564  C  CB  . PRO A 1 75  ? -21.493 -7.180  -7.193  1.00 10.41 ?  76   PRO A CB  1 
ATOM   565  C  CG  . PRO A 1 75  ? -22.504 -6.726  -6.213  1.00 13.22 ?  76   PRO A CG  1 
ATOM   566  C  CD  . PRO A 1 75  ? -21.781 -6.038  -5.077  1.00 11.35 ?  76   PRO A CD  1 
ATOM   567  N  N   . ASN A 1 76  ? -19.412 -4.160  -7.934  1.00 8.25  ?  77   ASN A N   1 
ATOM   568  C  CA  . ASN A 1 76  ? -19.528 -2.841  -8.547  1.00 6.95  ?  77   ASN A CA  1 
ATOM   569  C  C   . ASN A 1 76  ? -20.018 -2.839  -9.984  1.00 8.17  ?  77   ASN A C   1 
ATOM   570  O  O   . ASN A 1 76  ? -20.806 -1.941  -10.318 1.00 8.28  ?  77   ASN A O   1 
ATOM   571  C  CB  . ASN A 1 76  ? -18.218 -2.056  -8.412  1.00 8.27  ?  77   ASN A CB  1 
ATOM   572  C  CG  . ASN A 1 76  ? -17.909 -1.728  -6.987  1.00 7.82  ?  77   ASN A CG  1 
ATOM   573  O  OD1 . ASN A 1 76  ? -18.667 -0.995  -6.340  1.00 9.95  ?  77   ASN A OD1 1 
ATOM   574  N  ND2 . ASN A 1 76  ? -16.826 -2.282  -6.468  1.00 9.67  ?  77   ASN A ND2 1 
ATOM   575  N  N   . PRO A 1 77  ? -19.594 -3.746  -10.878 1.00 7.71  ?  78   PRO A N   1 
ATOM   576  C  CA  . PRO A 1 77  ? -20.079 -3.655  -12.267 1.00 7.93  ?  78   PRO A CA  1 
ATOM   577  C  C   . PRO A 1 77  ? -21.595 -3.739  -12.384 1.00 8.05  ?  78   PRO A C   1 
ATOM   578  O  O   . PRO A 1 77  ? -22.180 -3.110  -13.280 1.00 9.21  ?  78   PRO A O   1 
ATOM   579  C  CB  . PRO A 1 77  ? -19.392 -4.849  -12.948 1.00 10.47 ?  78   PRO A CB  1 
ATOM   580  C  CG  . PRO A 1 77  ? -18.129 -5.029  -12.171 1.00 9.35  ?  78   PRO A CG  1 
ATOM   581  C  CD  . PRO A 1 77  ? -18.559 -4.794  -10.741 1.00 7.89  ?  78   PRO A CD  1 
ATOM   582  N  N   . VAL A 1 78  ? -22.247 -4.496  -11.499 1.00 7.87  ?  79   VAL A N   1 
ATOM   583  C  CA  . VAL A 1 78  ? -23.704 -4.598  -11.485 1.00 9.16  ?  79   VAL A CA  1 
ATOM   584  C  C   . VAL A 1 78  ? -24.354 -3.242  -11.228 1.00 9.11  ?  79   VAL A C   1 
ATOM   585  O  O   . VAL A 1 78  ? -25.409 -2.932  -11.791 1.00 9.84  ?  79   VAL A O   1 
ATOM   586  C  CB  . VAL A 1 78  ? -24.114 -5.644  -10.429 1.00 9.14  ?  79   VAL A CB  1 
ATOM   587  C  CG1 . VAL A 1 78  ? -25.609 -5.638  -10.173 1.00 11.38 ?  79   VAL A CG1 1 
ATOM   588  C  CG2 . VAL A 1 78  ? -23.628 -7.040  -10.854 1.00 12.42 ?  79   VAL A CG2 1 
ATOM   589  N  N   . LEU A 1 79  ? -23.758 -2.428  -10.346 1.00 7.71  ?  80   LEU A N   1 
ATOM   590  C  CA  . LEU A 1 79  ? -24.281 -1.096  -10.043 1.00 7.38  ?  80   LEU A CA  1 
ATOM   591  C  C   . LEU A 1 79  ? -23.818 -0.076  -11.081 1.00 7.66  ?  80   LEU A C   1 
ATOM   592  O  O   . LEU A 1 79  ? -24.585 0.807   -11.475 1.00 9.69  ?  80   LEU A O   1 
ATOM   593  C  CB  . LEU A 1 79  ? -23.791 -0.676  -8.651  1.00 9.55  ?  80   LEU A CB  1 
ATOM   594  C  CG  . LEU A 1 79  ? -24.369 -1.389  -7.414  1.00 9.83  ?  80   LEU A CG  1 
ATOM   595  C  CD1 . LEU A 1 79  ? -23.849 -2.824  -7.261  1.00 11.52 ?  80   LEU A CD1 1 
ATOM   596  C  CD2 . LEU A 1 79  ? -24.045 -0.607  -6.137  1.00 11.50 ?  80   LEU A CD2 1 
ATOM   597  N  N   . LEU A 1 80  ? -22.573 -0.194  -11.544 1.00 8.07  ?  81   LEU A N   1 
ATOM   598  C  CA  . LEU A 1 80  ? -21.967 0.854   -12.362 1.00 8.23  ?  81   LEU A CA  1 
ATOM   599  C  C   . LEU A 1 80  ? -22.412 0.813   -13.816 1.00 9.00  ?  81   LEU A C   1 
ATOM   600  O  O   . LEU A 1 80  ? -22.584 1.873   -14.425 1.00 8.82  ?  81   LEU A O   1 
ATOM   601  C  CB  . LEU A 1 80  ? -20.444 0.768   -12.292 1.00 8.10  ?  81   LEU A CB  1 
ATOM   602  C  CG  . LEU A 1 80  ? -19.824 1.168   -10.958 1.00 7.72  ?  81   LEU A CG  1 
ATOM   603  C  CD1 . LEU A 1 80  ? -18.315 0.940   -11.020 1.00 11.65 ?  81   LEU A CD1 1 
ATOM   604  C  CD2 . LEU A 1 80  ? -20.122 2.629   -10.607 1.00 10.28 ?  81   LEU A CD2 1 
ATOM   605  N  N   . ARG A 1 81  ? -22.533 -0.366  -14.424 1.00 8.46  ?  82   ARG A N   1 
ATOM   606  C  CA  . ARG A 1 81  ? -22.935 -0.373  -15.830 1.00 8.28  ?  82   ARG A CA  1 
ATOM   607  C  C   . ARG A 1 81  ? -24.253 0.358   -16.039 1.00 8.01  ?  82   ARG A C   1 
ATOM   608  O  O   . ARG A 1 81  ? -24.330 1.198   -16.954 1.00 8.66  ?  82   ARG A O   1 
ATOM   609  C  CB  . ARG A 1 81  ? -22.942 -1.788  -16.414 1.00 9.07  ?  82   ARG A CB  1 
ATOM   610  C  CG  . ARG A 1 81  ? -21.552 -2.309  -16.789 1.00 11.19 ?  82   ARG A CG  1 
ATOM   611  C  CD  . ARG A 1 81  ? -21.648 -3.626  -17.576 1.00 11.63 ?  82   ARG A CD  1 
ATOM   612  N  NE  . ARG A 1 81  ? -22.155 -4.677  -16.703 1.00 11.88 ?  82   ARG A NE  1 
ATOM   613  C  CZ  . ARG A 1 81  ? -21.402 -5.574  -16.078 1.00 12.51 ?  82   ARG A CZ  1 
ATOM   614  N  NH1 . ARG A 1 81  ? -20.092 -5.603  -16.261 1.00 12.86 ?  82   ARG A NH1 1 
ATOM   615  N  NH2 . ARG A 1 81  ? -21.971 -6.446  -15.259 1.00 12.98 ?  82   ARG A NH2 1 
ATOM   616  N  N   . PRO A 1 82  ? -25.289 0.145   -15.223 1.00 7.83  ?  83   PRO A N   1 
ATOM   617  C  CA  . PRO A 1 82  ? -26.504 0.958   -15.372 1.00 8.74  ?  83   PRO A CA  1 
ATOM   618  C  C   . PRO A 1 82  ? -26.267 2.448   -15.178 1.00 9.12  ?  83   PRO A C   1 
ATOM   619  O  O   . PRO A 1 82  ? -26.790 3.259   -15.956 1.00 8.61  ?  83   PRO A O   1 
ATOM   620  C  CB  . PRO A 1 82  ? -27.432 0.363   -14.303 1.00 8.60  ?  83   PRO A CB  1 
ATOM   621  C  CG  . PRO A 1 82  ? -26.997 -1.073  -14.227 1.00 8.58  ?  83   PRO A CG  1 
ATOM   622  C  CD  . PRO A 1 82  ? -25.509 -0.962  -14.273 1.00 8.60  ?  83   PRO A CD  1 
ATOM   623  N  N   . ILE A 1 83  ? -25.510 2.836   -14.147 1.00 7.68  ?  84   ILE A N   1 
ATOM   624  C  CA  . ILE A 1 83  ? -25.238 4.249   -13.907 1.00 7.44  ?  84   ILE A CA  1 
ATOM   625  C  C   . ILE A 1 83  ? -24.523 4.854   -15.104 1.00 7.56  ?  84   ILE A C   1 
ATOM   626  O  O   . ILE A 1 83  ? -24.889 5.931   -15.593 1.00 8.22  ?  84   ILE A O   1 
ATOM   627  C  CB  . ILE A 1 83  ? -24.414 4.431   -12.619 1.00 7.73  ?  84   ILE A CB  1 
ATOM   628  C  CG1 . ILE A 1 83  ? -25.237 4.047   -11.387 1.00 8.15  ?  84   ILE A CG1 1 
ATOM   629  C  CG2 . ILE A 1 83  ? -23.930 5.882   -12.493 1.00 8.45  ?  84   ILE A CG2 1 
ATOM   630  C  CD1 . ILE A 1 83  ? -24.407 3.964   -10.133 1.00 9.85  ?  84   ILE A CD1 1 
ATOM   631  N  N   . LEU A 1 84  ? -23.498 4.162   -15.599 1.00 7.72  ?  85   LEU A N   1 
ATOM   632  C  CA  . LEU A 1 84  ? -22.691 4.712   -16.685 1.00 7.87  ?  85   LEU A CA  1 
ATOM   633  C  C   . LEU A 1 84  ? -23.497 4.795   -17.975 1.00 7.53  ?  85   LEU A C   1 
ATOM   634  O  O   . LEU A 1 84  ? -23.340 5.748   -18.749 1.00 9.03  ?  85   LEU A O   1 
ATOM   635  C  CB  . LEU A 1 84  ? -21.426 3.869   -16.864 1.00 8.40  ?  85   LEU A CB  1 
ATOM   636  C  CG  . LEU A 1 84  ? -20.493 3.930   -15.644 1.00 8.41  ?  85   LEU A CG  1 
ATOM   637  C  CD1 . LEU A 1 84  ? -19.363 2.895   -15.773 1.00 9.75  ?  85   LEU A CD1 1 
ATOM   638  C  CD2 . LEU A 1 84  ? -19.907 5.339   -15.474 1.00 9.70  ?  85   LEU A CD2 1 
ATOM   639  N  N   . ARG A 1 85  ? -24.382 3.825   -18.220 1.00 8.02  ?  86   ARG A N   1 
ATOM   640  C  CA  . ARG A 1 85  ? -25.234 3.904   -19.401 1.00 8.80  ?  86   ARG A CA  1 
ATOM   641  C  C   . ARG A 1 85  ? -26.209 5.075   -19.306 1.00 9.38  ?  86   ARG A C   1 
ATOM   642  O  O   . ARG A 1 85  ? -26.428 5.789   -20.292 1.00 9.34  ?  86   ARG A O   1 
ATOM   643  C  CB  . ARG A 1 85  ? -25.977 2.589   -19.592 1.00 8.90  ?  86   ARG A CB  1 
ATOM   644  C  CG  . ARG A 1 85  ? -26.545 2.450   -20.999 1.00 15.05 ?  86   ARG A CG  1 
ATOM   645  C  CD  . ARG A 1 85  ? -27.137 1.067   -21.251 1.00 17.66 ?  86   ARG A CD  1 
ATOM   646  N  NE  . ARG A 1 85  ? -26.228 -0.028  -20.912 1.00 15.37 ?  86   ARG A NE  1 
ATOM   647  C  CZ  . ARG A 1 85  ? -26.391 -0.845  -19.876 1.00 20.60 ?  86   ARG A CZ  1 
ATOM   648  N  NH1 . ARG A 1 85  ? -27.403 -0.662  -19.045 1.00 16.53 ?  86   ARG A NH1 1 
ATOM   649  N  NH2 . ARG A 1 85  ? -25.525 -1.834  -19.656 1.00 21.14 ?  86   ARG A NH2 1 
ATOM   650  N  N   . THR A 1 86  ? -26.801 5.292   -18.127 1.00 8.39  ?  87   THR A N   1 
ATOM   651  C  CA  . THR A 1 86  ? -27.695 6.430   -17.930 1.00 7.93  ?  87   THR A CA  1 
ATOM   652  C  C   . THR A 1 86  ? -26.968 7.757   -18.128 1.00 8.66  ?  87   THR A C   1 
ATOM   653  O  O   . THR A 1 86  ? -27.506 8.674   -18.765 1.00 9.16  ?  87   THR A O   1 
ATOM   654  C  CB  . THR A 1 86  ? -28.287 6.343   -16.522 1.00 8.69  ?  87   THR A CB  1 
ATOM   655  O  OG1 . THR A 1 86  ? -29.108 5.178   -16.445 1.00 10.62 ?  87   THR A OG1 1 
ATOM   656  C  CG2 . THR A 1 86  ? -29.138 7.561   -16.198 1.00 9.48  ?  87   THR A CG2 1 
ATOM   657  N  N   . LEU A 1 87  ? -25.750 7.886   -17.591 1.00 7.73  ?  88   LEU A N   1 
ATOM   658  C  CA  . LEU A 1 87  ? -25.008 9.132   -17.755 1.00 9.51  ?  88   LEU A CA  1 
ATOM   659  C  C   . LEU A 1 87  ? -24.682 9.374   -19.222 1.00 10.56 ?  88   LEU A C   1 
ATOM   660  O  O   . LEU A 1 87  ? -24.748 10.517  -19.697 1.00 9.57  ?  88   LEU A O   1 
ATOM   661  C  CB  . LEU A 1 87  ? -23.730 9.114   -16.909 1.00 8.23  ?  88   LEU A CB  1 
ATOM   662  C  CG  . LEU A 1 87  ? -23.953 8.994   -15.402 1.00 9.40  ?  88   LEU A CG  1 
ATOM   663  C  CD1 . LEU A 1 87  ? -22.638 9.195   -14.670 1.00 10.44 ?  88   LEU A CD1 1 
ATOM   664  C  CD2 . LEU A 1 87  ? -25.014 9.970   -14.925 1.00 11.91 ?  88   LEU A CD2 1 
ATOM   665  N  N   . HIS A 1 88  ? -24.355 8.312   -19.966 1.00 9.95  ?  89   HIS A N   1 
ATOM   666  C  CA  . HIS A 1 88  ? -24.178 8.466   -21.406 1.00 9.57  ?  89   HIS A CA  1 
ATOM   667  C  C   . HIS A 1 88  ? -25.473 8.939   -22.060 1.00 11.28 ?  89   HIS A C   1 
ATOM   668  O  O   . HIS A 1 88  ? -25.462 9.863   -22.886 1.00 10.62 ?  89   HIS A O   1 
ATOM   669  C  CB  . HIS A 1 88  ? -23.717 7.148   -22.041 1.00 10.27 ?  89   HIS A CB  1 
ATOM   670  C  CG  . HIS A 1 88  ? -23.805 7.158   -23.537 1.00 11.44 ?  89   HIS A CG  1 
ATOM   671  N  ND1 . HIS A 1 88  ? -22.871 7.798   -24.325 1.00 14.38 ?  89   HIS A ND1 1 
ATOM   672  C  CD2 . HIS A 1 88  ? -24.743 6.669   -24.385 1.00 12.89 ?  89   HIS A CD2 1 
ATOM   673  C  CE1 . HIS A 1 88  ? -23.212 7.669   -25.597 1.00 12.33 ?  89   HIS A CE1 1 
ATOM   674  N  NE2 . HIS A 1 88  ? -24.350 7.004   -25.660 1.00 14.72 ?  89   HIS A NE2 1 
ATOM   675  N  N   . ALA A 1 89  ? -26.604 8.319   -21.701 1.00 10.00 ?  90   ALA A N   1 
ATOM   676  C  CA  . ALA A 1 89  ? -27.882 8.713   -22.288 1.00 10.63 ?  90   ALA A CA  1 
ATOM   677  C  C   . ALA A 1 89  ? -28.230 10.153  -21.947 1.00 11.72 ?  90   ALA A C   1 
ATOM   678  O  O   . ALA A 1 89  ? -28.909 10.835  -22.732 1.00 13.72 ?  90   ALA A O   1 
ATOM   679  C  CB  . ALA A 1 89  ? -28.989 7.782   -21.800 1.00 11.13 ?  90   ALA A CB  1 
ATOM   680  N  N   . ALA A 1 90  ? -27.767 10.636  -20.796 1.00 9.77  ?  91   ALA A N   1 
ATOM   681  C  CA  . ALA A 1 90  ? -28.007 12.008  -20.375 1.00 10.42 ?  91   ALA A CA  1 
ATOM   682  C  C   . ALA A 1 90  ? -27.082 13.005  -21.053 1.00 11.81 ?  91   ALA A C   1 
ATOM   683  O  O   . ALA A 1 90  ? -27.246 14.214  -20.841 1.00 15.63 ?  91   ALA A O   1 
ATOM   684  C  CB  . ALA A 1 90  ? -27.843 12.118  -18.859 1.00 11.27 ?  91   ALA A CB  1 
ATOM   685  N  N   . GLY A 1 91  ? -26.106 12.538  -21.822 1.00 11.18 ?  92   GLY A N   1 
ATOM   686  C  CA  . GLY A 1 91  ? -25.226 13.420  -22.559 1.00 12.78 ?  92   GLY A CA  1 
ATOM   687  C  C   . GLY A 1 91  ? -23.866 13.669  -21.951 1.00 14.08 ?  92   GLY A C   1 
ATOM   688  O  O   . GLY A 1 91  ? -23.118 14.496  -22.481 1.00 16.97 ?  92   GLY A O   1 
ATOM   689  N  N   . LEU A 1 92  ? -23.520 13.004  -20.855 1.00 10.96 ?  93   LEU A N   1 
ATOM   690  C  CA  . LEU A 1 92  ? -22.183 13.144  -20.299 1.00 10.02 ?  93   LEU A CA  1 
ATOM   691  C  C   . LEU A 1 92  ? -21.218 12.274  -21.090 1.00 11.97 ?  93   LEU A C   1 
ATOM   692  O  O   . LEU A 1 92  ? -21.508 11.105  -21.362 1.00 14.79 ?  93   LEU A O   1 
ATOM   693  C  CB  . LEU A 1 92  ? -22.171 12.718  -18.830 1.00 11.31 ?  93   LEU A CB  1 
ATOM   694  C  CG  . LEU A 1 92  ? -22.723 13.734  -17.832 1.00 10.60 ?  93   LEU A CG  1 
ATOM   695  C  CD1 . LEU A 1 92  ? -24.250 13.681  -17.788 1.00 14.92 ?  93   LEU A CD1 1 
ATOM   696  C  CD2 . LEU A 1 92  ? -22.153 13.421  -16.460 1.00 13.76 ?  93   LEU A CD2 1 
ATOM   697  N  N   . ALA A 1 93  ? -20.083 12.843  -21.478 1.00 11.40 ?  94   ALA A N   1 
ATOM   698  C  CA  . ALA A 1 93  ? -19.053 12.029  -22.101 1.00 11.65 ?  94   ALA A CA  1 
ATOM   699  C  C   . ALA A 1 93  ? -18.272 11.269  -21.031 1.00 11.08 ?  94   ALA A C   1 
ATOM   700  O  O   . ALA A 1 93  ? -18.257 11.650  -19.857 1.00 10.98 ?  94   ALA A O   1 
ATOM   701  C  CB  . ALA A 1 93  ? -18.106 12.899  -22.925 1.00 13.46 ?  94   ALA A CB  1 
ATOM   702  N  N   . THR A 1 94  ? -17.620 10.175  -21.435 1.00 11.05 ?  95   THR A N   1 
ATOM   703  C  CA  . THR A 1 94  ? -16.917 9.374   -20.439 1.00 10.03 ?  95   THR A CA  1 
ATOM   704  C  C   . THR A 1 94  ? -15.859 10.190  -19.706 1.00 9.25  ?  95   THR A C   1 
ATOM   705  O  O   . THR A 1 94  ? -15.658 9.995   -18.506 1.00 9.66  ?  95   THR A O   1 
ATOM   706  C  CB  . THR A 1 94  ? -16.296 8.123   -21.049 1.00 12.09 ?  95   THR A CB  1 
ATOM   707  O  OG1 . THR A 1 94  ? -15.434 8.500   -22.128 1.00 11.77 ?  95   THR A OG1 1 
ATOM   708  C  CG2 . THR A 1 94  ? -17.379 7.161   -21.543 1.00 11.25 ?  95   THR A CG2 1 
ATOM   709  N  N   . GLN A 1 95  ? -15.195 11.123  -20.390 1.00 9.45  ?  96   GLN A N   1 
ATOM   710  C  CA  . GLN A 1 95  ? -14.195 11.953  -19.725 1.00 9.29  ?  96   GLN A CA  1 
ATOM   711  C  C   . GLN A 1 95  ? -14.802 12.889  -18.685 1.00 9.46  ?  96   GLN A C   1 
ATOM   712  O  O   . GLN A 1 95  ? -14.059 13.412  -17.847 1.00 12.33 ?  96   GLN A O   1 
ATOM   713  C  CB  . GLN A 1 95  ? -13.415 12.772  -20.760 1.00 9.33  ?  96   GLN A CB  1 
ATOM   714  C  CG  . GLN A 1 95  ? -12.268 12.001  -21.416 1.00 9.54  ?  96   GLN A CG  1 
ATOM   715  C  CD  . GLN A 1 95  ? -12.723 11.091  -22.556 1.00 8.91  ?  96   GLN A CD  1 
ATOM   716  O  OE1 . GLN A 1 95  ? -13.817 11.253  -23.109 1.00 9.46  ?  96   GLN A OE1 1 
ATOM   717  N  NE2 . GLN A 1 95  ? -11.865 10.141  -22.924 1.00 12.26 ?  96   GLN A NE2 1 
ATOM   718  N  N   . ASP A 1 96  ? -16.120 13.117  -18.728 1.00 8.48  ?  97   ASP A N   1 
ATOM   719  C  CA  . ASP A 1 96  ? -16.803 13.928  -17.721 1.00 11.74 ?  97   ASP A CA  1 
ATOM   720  C  C   . ASP A 1 96  ? -17.048 13.169  -16.425 1.00 10.78 ?  97   ASP A C   1 
ATOM   721  O  O   . ASP A 1 96  ? -17.566 13.761  -15.477 1.00 10.79 ?  97   ASP A O   1 
ATOM   722  C  CB  . ASP A 1 96  ? -18.187 14.388  -18.219 1.00 13.85 ?  97   ASP A CB  1 
ATOM   723  C  CG  . ASP A 1 96  ? -18.140 15.277  -19.458 1.00 17.37 ?  97   ASP A CG  1 
ATOM   724  O  OD1 . ASP A 1 96  ? -19.118 15.217  -20.238 1.00 23.81 ?  97   ASP A OD1 1 
ATOM   725  O  OD2 . ASP A 1 96  ? -17.175 16.044  -19.649 1.00 15.29 -1 97   ASP A OD2 1 
ATOM   726  N  N   . ILE A 1 97  ? -16.737 11.876  -16.372 1.00 8.69  ?  98   ILE A N   1 
ATOM   727  C  CA  . ILE A 1 97  ? -17.148 11.004  -15.271 1.00 10.00 ?  98   ILE A CA  1 
ATOM   728  C  C   . ILE A 1 97  ? -15.897 10.529  -14.541 1.00 10.72 ?  98   ILE A C   1 
ATOM   729  O  O   . ILE A 1 97  ? -15.005 9.927   -15.153 1.00 11.24 ?  98   ILE A O   1 
ATOM   730  C  CB  . ILE A 1 97  ? -17.960 9.808   -15.793 1.00 8.23  ?  98   ILE A CB  1 
ATOM   731  C  CG1 . ILE A 1 97  ? -19.215 10.288  -16.535 1.00 9.42  ?  98   ILE A CG1 1 
ATOM   732  C  CG2 . ILE A 1 97  ? -18.294 8.849   -14.652 1.00 9.96  ?  98   ILE A CG2 1 
ATOM   733  C  CD1 . ILE A 1 97  ? -19.865 9.229   -17.431 1.00 10.63 ?  98   ILE A CD1 1 
ATOM   734  N  N   . LEU A 1 98  ? -15.823 10.808  -13.238 1.00 8.02  ?  99   LEU A N   1 
ATOM   735  C  CA  . LEU A 1 98  ? -14.744 10.338  -12.375 1.00 8.92  ?  99   LEU A CA  1 
ATOM   736  C  C   . LEU A 1 98  ? -15.293 9.279   -11.427 1.00 7.95  ?  99   LEU A C   1 
ATOM   737  O  O   . LEU A 1 98  ? -16.330 9.495   -10.786 1.00 9.10  ?  99   LEU A O   1 
ATOM   738  C  CB  . LEU A 1 98  ? -14.180 11.495  -11.540 1.00 9.23  ?  99   LEU A CB  1 
ATOM   739  C  CG  . LEU A 1 98  ? -13.234 11.099  -10.401 1.00 10.47 ?  99   LEU A CG  1 
ATOM   740  C  CD1 . LEU A 1 98  ? -11.945 10.520  -10.969 1.00 11.38 ?  99   LEU A CD1 1 
ATOM   741  C  CD2 . LEU A 1 98  ? -12.940 12.311  -9.512  1.00 11.71 ?  99   LEU A CD2 1 
ATOM   742  N  N   . ILE A 1 99  ? -14.603 8.151   -11.326 1.00 6.96  ?  100  ILE A N   1 
ATOM   743  C  CA  . ILE A 1 99  ? -14.874 7.163   -10.289 1.00 6.78  ?  100  ILE A CA  1 
ATOM   744  C  C   . ILE A 1 99  ? -13.855 7.401   -9.180  1.00 8.54  ?  100  ILE A C   1 
ATOM   745  O  O   . ILE A 1 99  ? -12.642 7.367   -9.424  1.00 8.69  ?  100  ILE A O   1 
ATOM   746  C  CB  . ILE A 1 99  ? -14.775 5.738   -10.851 1.00 7.01  ?  100  ILE A CB  1 
ATOM   747  C  CG1 . ILE A 1 99  ? -15.860 5.521   -11.903 1.00 8.61  ?  100  ILE A CG1 1 
ATOM   748  C  CG2 . ILE A 1 99  ? -14.970 4.724   -9.735  1.00 10.50 ?  100  ILE A CG2 1 
ATOM   749  C  CD1 . ILE A 1 99  ? -15.744 4.199   -12.645 1.00 9.60  ?  100  ILE A CD1 1 
ATOM   750  N  N   . LEU A 1 100 ? -14.339 7.689   -7.969  1.00 7.14  ?  101  LEU A N   1 
ATOM   751  C  CA  . LEU A 1 100 ? -13.481 8.046   -6.844  1.00 7.79  ?  101  LEU A CA  1 
ATOM   752  C  C   . LEU A 1 100 ? -13.602 6.966   -5.777  1.00 6.71  ?  101  LEU A C   1 
ATOM   753  O  O   . LEU A 1 100 ? -14.699 6.704   -5.272  1.00 7.41  ?  101  LEU A O   1 
ATOM   754  C  CB  . LEU A 1 100 ? -13.856 9.431   -6.293  1.00 7.54  ?  101  LEU A CB  1 
ATOM   755  C  CG  . LEU A 1 100 ? -13.074 9.969   -5.092  1.00 7.37  ?  101  LEU A CG  1 
ATOM   756  C  CD1 . LEU A 1 100 ? -11.570 10.038  -5.352  1.00 9.39  ?  101  LEU A CD1 1 
ATOM   757  C  CD2 . LEU A 1 100 ? -13.617 11.324  -4.686  1.00 8.29  ?  101  LEU A CD2 1 
ATOM   758  N  N   . VAL A 1 101 ? -12.476 6.338   -5.444  1.00 7.64  ?  102  VAL A N   1 
ATOM   759  C  CA  . VAL A 1 101 ? -12.455 5.262   -4.458  1.00 6.91  ?  102  VAL A CA  1 
ATOM   760  C  C   . VAL A 1 101 ? -12.496 5.881   -3.063  1.00 7.35  ?  102  VAL A C   1 
ATOM   761  O  O   . VAL A 1 101 ? -11.564 6.583   -2.639  1.00 7.62  ?  102  VAL A O   1 
ATOM   762  C  CB  . VAL A 1 101 ? -11.238 4.353   -4.641  1.00 6.09  ?  102  VAL A CB  1 
ATOM   763  C  CG1 . VAL A 1 101 ? -11.283 3.205   -3.629  1.00 8.12  ?  102  VAL A CG1 1 
ATOM   764  C  CG2 . VAL A 1 101 ? -11.194 3.800   -6.057  1.00 8.51  ?  102  VAL A CG2 1 
ATOM   765  N  N   . ALA A 1 102 ? -13.598 5.627   -2.351  1.00 6.30  ?  103  ALA A N   1 
ATOM   766  C  CA  . ALA A 1 102 ? -13.876 6.199   -1.036  1.00 6.84  ?  103  ALA A CA  1 
ATOM   767  C  C   . ALA A 1 102 ? -13.171 5.368   0.031   1.00 7.78  ?  103  ALA A C   1 
ATOM   768  O  O   . ALA A 1 102 ? -13.771 4.557   0.740   1.00 8.59  ?  103  ALA A O   1 
ATOM   769  C  CB  . ALA A 1 102 ? -15.378 6.254   -0.808  1.00 8.45  ?  103  ALA A CB  1 
ATOM   770  N  N   . THR A 1 103 ? -11.863 5.600   0.148   1.00 6.42  ?  104  THR A N   1 
ATOM   771  C  CA  . THR A 1 103 ? -11.005 4.850   1.058   1.00 7.55  ?  104  THR A CA  1 
ATOM   772  C  C   . THR A 1 103 ? -11.215 5.207   2.527   1.00 6.72  ?  104  THR A C   1 
ATOM   773  O  O   . THR A 1 103 ? -10.734 4.467   3.393   1.00 7.07  ?  104  THR A O   1 
ATOM   774  C  CB  . THR A 1 103 ? -9.557  5.200   0.733   1.00 6.87  ?  104  THR A CB  1 
ATOM   775  O  OG1 . THR A 1 103 ? -9.436  6.629   0.760   1.00 8.12  ?  104  THR A OG1 1 
ATOM   776  C  CG2 . THR A 1 103 ? -9.135  4.678   -0.643  1.00 8.29  ?  104  THR A CG2 1 
ATOM   777  N  N   . GLY A 1 104 ? -11.874 6.327   2.848   1.00 7.12  ?  105  GLY A N   1 
ATOM   778  C  CA  . GLY A 1 104 ? -11.807 6.801   4.224   1.00 6.86  ?  105  GLY A CA  1 
ATOM   779  C  C   . GLY A 1 104 ? -10.371 7.159   4.536   1.00 7.90  ?  105  GLY A C   1 
ATOM   780  O  O   . GLY A 1 104 ? -9.735  7.927   3.808   1.00 7.96  ?  105  GLY A O   1 
ATOM   781  N  N   . LEU A 1 105 ? -9.838  6.575   5.610   1.00 7.96  ?  106  LEU A N   1 
ATOM   782  C  CA  . LEU A 1 105 ? -8.434  6.693   5.968   1.00 8.55  ?  106  LEU A CA  1 
ATOM   783  C  C   . LEU A 1 105 ? -7.621  5.466   5.582   1.00 8.28  ?  106  LEU A C   1 
ATOM   784  O  O   . LEU A 1 105 ? -6.446  5.362   5.966   1.00 8.99  ?  106  LEU A O   1 
ATOM   785  C  CB  . LEU A 1 105 ? -8.278  7.018   7.459   1.00 7.90  ?  106  LEU A CB  1 
ATOM   786  C  CG  . LEU A 1 105 ? -8.160  8.499   7.826   1.00 9.24  ?  106  LEU A CG  1 
ATOM   787  C  CD1 . LEU A 1 105 ? -6.814  9.016   7.342   1.00 12.64 ?  106  LEU A CD1 1 
ATOM   788  C  CD2 . LEU A 1 105 ? -9.302  9.325   7.233   1.00 9.71  ?  106  LEU A CD2 1 
ATOM   789  N  N   . HIS A 1 106 ? -8.210  4.535   4.835   1.00 7.68  ?  107  HIS A N   1 
ATOM   790  C  CA  . HIS A 1 106 ? -7.452  3.384   4.357   1.00 7.02  ?  107  HIS A CA  1 
ATOM   791  C  C   . HIS A 1 106 ? -6.430  3.808   3.316   1.00 7.60  ?  107  HIS A C   1 
ATOM   792  O  O   . HIS A 1 106 ? -6.561  4.843   2.658   1.00 8.30  ?  107  HIS A O   1 
ATOM   793  C  CB  . HIS A 1 106 ? -8.352  2.336   3.690   1.00 7.91  ?  107  HIS A CB  1 
ATOM   794  C  CG  . HIS A 1 106 ? -9.436  1.801   4.571   1.00 7.26  ?  107  HIS A CG  1 
ATOM   795  N  ND1 . HIS A 1 106 ? -10.527 1.123   4.064   1.00 7.28  ?  107  HIS A ND1 1 
ATOM   796  C  CD2 . HIS A 1 106 ? -9.613  1.851   5.913   1.00 7.70  ?  107  HIS A CD2 1 
ATOM   797  C  CE1 . HIS A 1 106 ? -11.321 0.766   5.060   1.00 6.51  ?  107  HIS A CE1 1 
ATOM   798  N  NE2 . HIS A 1 106 ? -10.795 1.203   6.191   1.00 7.79  ?  107  HIS A NE2 1 
ATOM   799  N  N   . ARG A 1 107 ? -5.420  2.957   3.151   1.00 9.12  ?  108  ARG A N   1 
ATOM   800  C  CA  . ARG A 1 107 ? -4.458  3.084   2.068   1.00 9.29  ?  108  ARG A CA  1 
ATOM   801  C  C   . ARG A 1 107 ? -5.170  3.096   0.714   1.00 8.58  ?  108  ARG A C   1 
ATOM   802  O  O   . ARG A 1 107 ? -6.307  2.623   0.582   1.00 9.05  ?  108  ARG A O   1 
ATOM   803  C  CB  . ARG A 1 107 ? -3.498  1.895   2.117   1.00 9.21  ?  108  ARG A CB  1 
ATOM   804  C  CG  . ARG A 1 107 ? -4.196  0.539   2.028   1.00 9.97  ?  108  ARG A CG  1 
ATOM   805  C  CD  . ARG A 1 107 ? -3.258  -0.513  1.454   1.00 10.15 ?  108  ARG A CD  1 
ATOM   806  N  NE  . ARG A 1 107 ? -3.863  -1.841  1.369   1.00 10.12 ?  108  ARG A NE  1 
ATOM   807  C  CZ  . ARG A 1 107 ? -4.542  -2.272  0.306   1.00 10.78 ?  108  ARG A CZ  1 
ATOM   808  N  NH1 . ARG A 1 107 ? -4.744  -1.457  -0.729  1.00 11.52 ?  108  ARG A NH1 1 
ATOM   809  N  NH2 . ARG A 1 107 ? -5.036  -3.498  0.281   1.00 11.29 ?  108  ARG A NH2 1 
ATOM   810  N  N   . PRO A 1 108 ? -4.518  3.614   -0.321  1.00 8.69  ?  109  PRO A N   1 
ATOM   811  C  CA  . PRO A 1 108 ? -5.159  3.640   -1.638  1.00 9.54  ?  109  PRO A CA  1 
ATOM   812  C  C   . PRO A 1 108 ? -5.310  2.239   -2.219  1.00 9.04  ?  109  PRO A C   1 
ATOM   813  O  O   . PRO A 1 108 ? -4.587  1.300   -1.863  1.00 9.35  ?  109  PRO A O   1 
ATOM   814  C  CB  . PRO A 1 108 ? -4.211  4.506   -2.477  1.00 9.90  ?  109  PRO A CB  1 
ATOM   815  C  CG  . PRO A 1 108 ? -2.873  4.356   -1.801  1.00 10.06 ?  109  PRO A CG  1 
ATOM   816  C  CD  . PRO A 1 108 ? -3.217  4.303   -0.323  1.00 9.92  ?  109  PRO A CD  1 
ATOM   817  N  N   . SER A 1 109 ? -6.301  2.091   -3.091  1.00 8.37  ?  110  SER A N   1 
ATOM   818  C  CA  . SER A 1 109 ? -6.425  0.846   -3.835  1.00 8.93  ?  110  SER A CA  1 
ATOM   819  C  C   . SER A 1 109 ? -5.269  0.719   -4.828  1.00 10.35 ?  110  SER A C   1 
ATOM   820  O  O   . SER A 1 109 ? -4.775  1.713   -5.371  1.00 10.84 ?  110  SER A O   1 
ATOM   821  C  CB  . SER A 1 109 ? -7.775  0.768   -4.560  1.00 9.57  ?  110  SER A CB  1 
ATOM   822  O  OG  . SER A 1 109 ? -7.914  1.786   -5.548  1.00 9.30  ?  110  SER A OG  1 
ATOM   823  N  N   . THR A 1 110 ? -4.818  -0.523  -5.036  1.00 10.70 ?  111  THR A N   1 
ATOM   824  C  CA  . THR A 1 110 ? -3.768  -0.781  -6.016  1.00 10.51 ?  111  THR A CA  1 
ATOM   825  C  C   . THR A 1 110 ? -4.369  -0.912  -7.408  1.00 12.39 ?  111  THR A C   1 
ATOM   826  O  O   . THR A 1 110 ? -5.586  -1.077  -7.561  1.00 10.73 ?  111  THR A O   1 
ATOM   827  C  CB  . THR A 1 110 ? -3.047  -2.084  -5.672  1.00 11.56 ?  111  THR A CB  1 
ATOM   828  O  OG1 . THR A 1 110 ? -3.956  -3.174  -5.834  1.00 11.66 ?  111  THR A OG1 1 
ATOM   829  C  CG2 . THR A 1 110 ? -2.508  -2.069  -4.243  1.00 13.24 ?  111  THR A CG2 1 
ATOM   830  N  N   . PRO A 1 111 ? -3.541  -0.850  -8.462  1.00 11.94 ?  112  PRO A N   1 
ATOM   831  C  CA  . PRO A 1 111 ? -4.076  -1.126  -9.804  1.00 11.78 ?  112  PRO A CA  1 
ATOM   832  C  C   . PRO A 1 111 ? -4.828  -2.447  -9.903  1.00 12.91 ?  112  PRO A C   1 
ATOM   833  O  O   . PRO A 1 111 ? -5.912  -2.492  -10.500 1.00 11.75 ?  112  PRO A O   1 
ATOM   834  C  CB  . PRO A 1 111 ? -2.819  -1.081  -10.685 1.00 14.17 ?  112  PRO A CB  1 
ATOM   835  C  CG  . PRO A 1 111 ? -1.945  -0.082  -9.983  1.00 14.89 ?  112  PRO A CG  1 
ATOM   836  C  CD  . PRO A 1 111 ? -2.127  -0.426  -8.519  1.00 14.11 ?  112  PRO A CD  1 
ATOM   837  N  N   . ALA A 1 112 ? -4.299  -3.518  -9.313  1.00 11.70 ?  113  ALA A N   1 
ATOM   838  C  CA  . ALA A 1 112 ? -4.979  -4.804  -9.394  1.00 11.76 ?  113  ALA A CA  1 
ATOM   839  C  C   . ALA A 1 112 ? -6.291  -4.786  -8.624  1.00 11.21 ?  113  ALA A C   1 
ATOM   840  O  O   . ALA A 1 112 ? -7.277  -5.398  -9.052  1.00 11.56 ?  113  ALA A O   1 
ATOM   841  C  CB  . ALA A 1 112 ? -4.068  -5.925  -8.889  1.00 15.09 ?  113  ALA A CB  1 
ATOM   842  N  N   . GLU A 1 113 ? -6.326  -4.077  -7.492  1.00 9.34  ?  114  GLU A N   1 
ATOM   843  C  CA  . GLU A 1 113 ? -7.567  -3.980  -6.737  1.00 9.91  ?  114  GLU A CA  1 
ATOM   844  C  C   . GLU A 1 113 ? -8.636  -3.245  -7.532  1.00 8.40  ?  114  GLU A C   1 
ATOM   845  O  O   . GLU A 1 113 ? -9.810  -3.636  -7.503  1.00 9.06  ?  114  GLU A O   1 
ATOM   846  C  CB  . GLU A 1 113 ? -7.307  -3.306  -5.396  1.00 8.70  ?  114  GLU A CB  1 
ATOM   847  C  CG  . GLU A 1 113 ? -6.698  -4.274  -4.388  1.00 10.36 ?  114  GLU A CG  1 
ATOM   848  C  CD  . GLU A 1 113 ? -6.270  -3.610  -3.103  1.00 12.55 ?  114  GLU A CD  1 
ATOM   849  O  OE1 . GLU A 1 113 ? -5.914  -4.352  -2.168  1.00 11.96 ?  114  GLU A OE1 1 
ATOM   850  O  OE2 . GLU A 1 113 ? -6.269  -2.358  -3.026  1.00 10.40 -1 114  GLU A OE2 1 
ATOM   851  N  N   . LYS A 1 114 ? -8.253  -2.184  -8.253  1.00 8.58  ?  115  LYS A N   1 
ATOM   852  C  CA  . LYS A 1 114 ? -9.229  -1.492  -9.085  1.00 9.39  ?  115  LYS A CA  1 
ATOM   853  C  C   . LYS A 1 114 ? -9.853  -2.436  -10.102 1.00 9.87  ?  115  LYS A C   1 
ATOM   854  O  O   . LYS A 1 114 ? -11.059 -2.373  -10.358 1.00 10.06 ?  115  LYS A O   1 
ATOM   855  C  CB  . LYS A 1 114 ? -8.577  -0.294  -9.774  1.00 9.33  ?  115  LYS A CB  1 
ATOM   856  C  CG  . LYS A 1 114 ? -8.336  0.870   -8.824  1.00 9.32  ?  115  LYS A CG  1 
ATOM   857  C  CD  . LYS A 1 114 ? -7.583  2.014   -9.512  1.00 10.44 ?  115  LYS A CD  1 
ATOM   858  C  CE  . LYS A 1 114 ? -7.341  3.167   -8.542  1.00 10.57 ?  115  LYS A CE  1 
ATOM   859  N  NZ  . LYS A 1 114 ? -6.273  2.834   -7.550  1.00 11.09 ?  115  LYS A NZ  1 
ATOM   860  N  N   . VAL A 1 115 ? -9.051  -3.335  -10.680 1.00 9.21  ?  116  VAL A N   1 
ATOM   861  C  CA  . VAL A 1 115 ? -9.592  -4.311  -11.622 1.00 11.51 ?  116  VAL A CA  1 
ATOM   862  C  C   . VAL A 1 115 ? -10.517 -5.297  -10.909 1.00 11.56 ?  116  VAL A C   1 
ATOM   863  O  O   . VAL A 1 115 ? -11.612 -5.609  -11.399 1.00 11.76 ?  116  VAL A O   1 
ATOM   864  C  CB  . VAL A 1 115 ? -8.450  -5.014  -12.382 1.00 11.34 ?  116  VAL A CB  1 
ATOM   865  C  CG1 . VAL A 1 115 ? -8.978  -6.216  -13.169 1.00 13.29 ?  116  VAL A CG1 1 
ATOM   866  C  CG2 . VAL A 1 115 ? -7.740  -4.010  -13.294 1.00 12.59 ?  116  VAL A CG2 1 
ATOM   867  N  N   . GLU A 1 116 ? -10.096 -5.803  -9.744  1.00 9.04  ?  117  GLU A N   1 
ATOM   868  C  CA  . GLU A 1 116 ? -10.949 -6.708  -8.973  1.00 10.85 ?  117  GLU A CA  1 
ATOM   869  C  C   . GLU A 1 116 ? -12.260 -6.032  -8.578  1.00 11.80 ?  117  GLU A C   1 
ATOM   870  O  O   . GLU A 1 116 ? -13.331 -6.644  -8.642  1.00 13.85 ?  117  GLU A O   1 
ATOM   871  C  CB  . GLU A 1 116 ? -10.205 -7.195  -7.723  1.00 11.10 ?  117  GLU A CB  1 
ATOM   872  C  CG  . GLU A 1 116 ? -11.091 -8.027  -6.772  1.00 14.60 ?  117  GLU A CG  1 
ATOM   873  C  CD  . GLU A 1 116 ? -10.340 -8.673  -5.613  1.00 18.08 ?  117  GLU A CD  1 
ATOM   874  O  OE1 . GLU A 1 116 ? -9.107  -8.499  -5.504  1.00 15.83 ?  117  GLU A OE1 1 
ATOM   875  O  OE2 . GLU A 1 116 ? -11.006 -9.338  -4.789  1.00 18.06 -1 117  GLU A OE2 1 
ATOM   876  N  N   . MET A 1 117 ? -12.191 -4.760  -8.176  1.00 9.86  ?  118  MET A N   1 
ATOM   877  C  CA  . MET A 1 117 ? -13.369 -4.035  -7.706  1.00 10.75 ?  118  MET A CA  1 
ATOM   878  C  C   . MET A 1 117 ? -14.318 -3.694  -8.851  1.00 9.35  ?  118  MET A C   1 
ATOM   879  O  O   . MET A 1 117 ? -15.540 -3.798  -8.697  1.00 10.70 ?  118  MET A O   1 
ATOM   880  C  CB  . MET A 1 117 ? -12.936 -2.707  -7.072  1.00 9.95  ?  118  MET A CB  1 
ATOM   881  C  CG  . MET A 1 117 ? -12.308 -2.825  -5.692  1.00 11.92 ?  118  MET A CG  1 
ATOM   882  S  SD  . MET A 1 117 ? -11.168 -1.466  -5.301  1.00 13.60 ?  118  MET A SD  1 
ATOM   883  C  CE  . MET A 1 117 ? -12.096 -0.022  -5.832  1.00 11.57 ?  118  MET A CE  1 
ATOM   884  N  N   . LEU A 1 118 ? -13.781 -3.232  -9.985  1.00 8.88  ?  119  LEU A N   1 
ATOM   885  C  CA  . LEU A 1 118 ? -14.576 -2.529  -10.989 1.00 9.20  ?  119  LEU A CA  1 
ATOM   886  C  C   . LEU A 1 118 ? -14.723 -3.282  -12.295 1.00 9.73  ?  119  LEU A C   1 
ATOM   887  O  O   . LEU A 1 118 ? -15.562 -2.887  -13.115 1.00 10.58 ?  119  LEU A O   1 
ATOM   888  C  CB  . LEU A 1 118 ? -13.978 -1.144  -11.288 1.00 11.37 ?  119  LEU A CB  1 
ATOM   889  C  CG  . LEU A 1 118 ? -13.717 -0.278  -10.070 1.00 10.73 ?  119  LEU A CG  1 
ATOM   890  C  CD1 . LEU A 1 118 ? -12.994 0.983   -10.499 1.00 12.63 ?  119  LEU A CD1 1 
ATOM   891  C  CD2 . LEU A 1 118 ? -15.017 0.069   -9.336  1.00 12.45 ?  119  LEU A CD2 1 
ATOM   892  N  N   . SER A 1 119 ? -13.949 -4.353  -12.489 1.00 11.85 ?  120  SER A N   1 
ATOM   893  C  CA  . SER A 1 119 ? -13.731 -5.061  -13.754 1.00 11.61 ?  120  SER A CA  1 
ATOM   894  C  C   . SER A 1 119 ? -12.698 -4.346  -14.621 1.00 11.02 ?  120  SER A C   1 
ATOM   895  O  O   . SER A 1 119 ? -12.553 -3.121  -14.555 1.00 11.19 ?  120  SER A O   1 
ATOM   896  C  CB  . SER A 1 119 ? -15.017 -5.339  -14.543 1.00 14.52 ?  120  SER A CB  1 
ATOM   897  O  OG  . SER A 1 119 ? -15.383 -4.211  -15.326 1.00 14.61 ?  120  SER A OG  1 
ATOM   898  N  N   . GLU A 1 120 ? -11.978 -5.119  -15.443 1.00 13.37 ?  121  GLU A N   1 
ATOM   899  C  CA  . GLU A 1 120 ? -10.926 -4.551  -16.283 1.00 13.06 ?  121  GLU A CA  1 
ATOM   900  C  C   . GLU A 1 120 ? -11.476 -3.506  -17.244 1.00 12.26 ?  121  GLU A C   1 
ATOM   901  O  O   . GLU A 1 120 ? -10.873 -2.444  -17.425 1.00 11.87 ?  121  GLU A O   1 
ATOM   902  C  CB  . GLU A 1 120 ? -10.222 -5.667  -17.060 1.00 16.77 ?  121  GLU A CB  1 
ATOM   903  C  CG  . GLU A 1 120 ? -9.125  -5.187  -18.008 1.00 24.69 ?  121  GLU A CG  1 
ATOM   904  C  CD  . GLU A 1 120 ? -8.023  -4.415  -17.298 1.00 36.64 ?  121  GLU A CD  1 
ATOM   905  O  OE1 . GLU A 1 120 ? -7.144  -5.060  -16.690 1.00 45.08 ?  121  GLU A OE1 1 
ATOM   906  O  OE2 . GLU A 1 120 ? -8.036  -3.163  -17.346 1.00 44.90 -1 121  GLU A OE2 1 
ATOM   907  N  N   . GLU A 1 121 ? -12.625 -3.776  -17.864 1.00 11.29 ?  122  GLU A N   1 
ATOM   908  C  CA  . GLU A 1 121 ? -13.096 -2.864  -18.898 1.00 14.04 ?  122  GLU A CA  1 
ATOM   909  C  C   . GLU A 1 121 ? -13.492 -1.519  -18.311 1.00 13.89 ?  122  GLU A C   1 
ATOM   910  O  O   . GLU A 1 121 ? -13.153 -0.476  -18.869 1.00 14.66 ?  122  GLU A O   1 
ATOM   911  C  CB  . GLU A 1 121 ? -14.234 -3.494  -19.700 1.00 17.51 ?  122  GLU A CB  1 
ATOM   912  C  CG  . GLU A 1 121 ? -14.303 -3.024  -21.154 1.00 24.58 ?  122  GLU A CG  1 
ATOM   913  C  CD  . GLU A 1 121 ? -12.958 -3.129  -21.867 1.00 19.73 ?  122  GLU A CD  1 
ATOM   914  O  OE1 . GLU A 1 121 ? -12.276 -4.163  -21.697 1.00 29.35 ?  122  GLU A OE1 1 
ATOM   915  O  OE2 . GLU A 1 121 ? -12.592 -2.176  -22.583 1.00 27.72 -1 122  GLU A OE2 1 
ATOM   916  N  N   . ILE A 1 122 ? -14.197 -1.515  -17.179 1.00 10.80 ?  123  ILE A N   1 
ATOM   917  C  CA  . ILE A 1 122 ? -14.554 -0.242  -16.560 1.00 10.10 ?  123  ILE A CA  1 
ATOM   918  C  C   . ILE A 1 122 ? -13.304 0.482   -16.084 1.00 9.92  ?  123  ILE A C   1 
ATOM   919  O  O   . ILE A 1 122 ? -13.154 1.694   -16.289 1.00 12.39 ?  123  ILE A O   1 
ATOM   920  C  CB  . ILE A 1 122 ? -15.569 -0.465  -15.425 1.00 10.16 ?  123  ILE A CB  1 
ATOM   921  C  CG1 . ILE A 1 122 ? -16.887 -0.986  -16.006 1.00 13.40 ?  123  ILE A CG1 1 
ATOM   922  C  CG2 . ILE A 1 122 ? -15.784 0.827   -14.640 1.00 13.40 ?  123  ILE A CG2 1 
ATOM   923  C  CD1 . ILE A 1 122 ? -17.957 -1.247  -14.958 1.00 13.79 ?  123  ILE A CD1 1 
ATOM   924  N  N   . ALA A 1 123 ? -12.374 -0.259  -15.473 1.00 10.12 ?  124  ALA A N   1 
ATOM   925  C  CA  . ALA A 1 123 ? -11.200 0.351   -14.859 1.00 12.87 ?  124  ALA A CA  1 
ATOM   926  C  C   . ALA A 1 123 ? -10.303 1.042   -15.875 1.00 12.28 ?  124  ALA A C   1 
ATOM   927  O  O   . ALA A 1 123 ? -9.620  2.011   -15.532 1.00 14.24 ?  124  ALA A O   1 
ATOM   928  C  CB  . ALA A 1 123 ? -10.412 -0.685  -14.056 1.00 13.50 ?  124  ALA A CB  1 
ATOM   929  N  N   . ARG A 1 124 ? -10.283 0.586   -17.124 1.00 11.63 ?  125  ARG A N   1 
ATOM   930  C  CA  . ARG A 1 124 ? -9.431  1.237   -18.112 1.00 13.19 ?  125  ARG A CA  1 
ATOM   931  C  C   . ARG A 1 124 ? -10.173 2.251   -18.976 1.00 13.46 ?  125  ARG A C   1 
ATOM   932  O  O   . ARG A 1 124 ? -9.539  2.934   -19.787 1.00 14.21 ?  125  ARG A O   1 
ATOM   933  C  CB  . ARG A 1 124 ? -8.726  0.207   -19.003 1.00 13.44 ?  125  ARG A CB  1 
ATOM   934  C  CG  . ARG A 1 124 ? -9.637  -0.488  -19.987 1.00 13.56 ?  125  ARG A CG  1 
ATOM   935  C  CD  . ARG A 1 124 ? -8.822  -1.285  -21.008 1.00 16.47 ?  125  ARG A CD  1 
ATOM   936  N  NE  . ARG A 1 124 ? -9.690  -1.919  -21.989 1.00 15.55 ?  125  ARG A NE  1 
ATOM   937  C  CZ  . ARG A 1 124 ? -9.277  -2.358  -23.176 1.00 12.83 ?  125  ARG A CZ  1 
ATOM   938  N  NH1 . ARG A 1 124 ? -8.004  -2.219  -23.519 1.00 16.03 ?  125  ARG A NH1 1 
ATOM   939  N  NH2 . ARG A 1 124 ? -10.140 -2.925  -24.009 1.00 15.55 ?  125  ARG A NH2 1 
ATOM   940  N  N   . THR A 1 125 ? -11.491 2.371   -18.824 1.00 12.12 ?  126  THR A N   1 
ATOM   941  C  CA  . THR A 1 125 ? -12.294 3.234   -19.684 1.00 12.83 ?  126  THR A CA  1 
ATOM   942  C  C   . THR A 1 125 ? -12.668 4.554   -19.017 1.00 13.93 ?  126  THR A C   1 
ATOM   943  O  O   . THR A 1 125 ? -12.899 5.548   -19.717 1.00 14.78 ?  126  THR A O   1 
ATOM   944  C  CB  . THR A 1 125 ? -13.543 2.453   -20.135 1.00 12.42 ?  126  THR A CB  1 
ATOM   945  O  OG1 . THR A 1 125 ? -13.127 1.271   -20.828 1.00 14.42 ?  126  THR A OG1 1 
ATOM   946  C  CG2 . THR A 1 125 ? -14.422 3.256   -21.074 1.00 16.14 ?  126  THR A CG2 1 
ATOM   947  N  N   . TYR A 1 126 ? -12.696 4.602   -17.685 1.00 11.78 ?  127  TYR A N   1 
ATOM   948  C  CA  . TYR A 1 126 ? -13.033 5.796   -16.930 1.00 13.09 ?  127  TYR A CA  1 
ATOM   949  C  C   . TYR A 1 126 ? -11.868 6.128   -16.005 1.00 12.27 ?  127  TYR A C   1 
ATOM   950  O  O   . TYR A 1 126 ? -11.115 5.232   -15.600 1.00 12.57 ?  127  TYR A O   1 
ATOM   951  C  CB  . TYR A 1 126 ? -14.328 5.547   -16.116 1.00 13.85 ?  127  TYR A CB  1 
ATOM   952  C  CG  . TYR A 1 126 ? -15.528 5.261   -17.008 1.00 12.17 ?  127  TYR A CG  1 
ATOM   953  C  CD1 . TYR A 1 126 ? -15.782 3.978   -17.485 1.00 13.24 ?  127  TYR A CD1 1 
ATOM   954  C  CD2 . TYR A 1 126 ? -16.390 6.279   -17.396 1.00 14.07 ?  127  TYR A CD2 1 
ATOM   955  C  CE1 . TYR A 1 126 ? -16.847 3.721   -18.323 1.00 13.54 ?  127  TYR A CE1 1 
ATOM   956  C  CE2 . TYR A 1 126 ? -17.466 6.021   -18.229 1.00 14.03 ?  127  TYR A CE2 1 
ATOM   957  C  CZ  . TYR A 1 126 ? -17.690 4.744   -18.691 1.00 12.46 ?  127  TYR A CZ  1 
ATOM   958  O  OH  . TYR A 1 126 ? -18.746 4.465   -19.534 1.00 14.34 ?  127  TYR A OH  1 
ATOM   959  N  N   . ARG A 1 127 ? -11.711 7.416   -15.675 1.00 12.42 ?  128  ARG A N   1 
ATOM   960  C  CA  . ARG A 1 127 ? -10.715 7.815   -14.684 1.00 10.79 ?  128  ARG A CA  1 
ATOM   961  C  C   . ARG A 1 127 ? -11.105 7.230   -13.338 1.00 9.60  ?  128  ARG A C   1 
ATOM   962  O  O   . ARG A 1 127 ? -12.227 7.435   -12.869 1.00 10.21 ?  128  ARG A O   1 
ATOM   963  C  CB  . ARG A 1 127 ? -10.680 9.338   -14.494 1.00 16.51 ?  128  ARG A CB  1 
ATOM   964  C  CG  . ARG A 1 127 ? -9.720  10.159  -15.328 1.00 27.64 ?  128  ARG A CG  1 
ATOM   965  C  CD  . ARG A 1 127 ? -9.983  11.662  -15.081 1.00 21.61 ?  128  ARG A CD  1 
ATOM   966  N  NE  . ARG A 1 127 ? -11.370 12.023  -15.369 1.00 23.36 ?  128  ARG A NE  1 
ATOM   967  C  CZ  . ARG A 1 127 ? -12.095 12.905  -14.682 1.00 24.78 ?  128  ARG A CZ  1 
ATOM   968  N  NH1 . ARG A 1 127 ? -13.356 13.123  -15.037 1.00 23.86 ?  128  ARG A NH1 1 
ATOM   969  N  NH2 . ARG A 1 127 ? -11.572 13.586  -13.658 1.00 18.09 ?  128  ARG A NH2 1 
ATOM   970  N  N   . VAL A 1 128 ? -10.172 6.538   -12.699 1.00 8.63  ?  129  VAL A N   1 
ATOM   971  C  CA  . VAL A 1 128 ? -10.396 5.987   -11.370 1.00 7.57  ?  129  VAL A CA  1 
ATOM   972  C  C   . VAL A 1 128 ? -9.280  6.494   -10.473 1.00 9.03  ?  129  VAL A C   1 
ATOM   973  O  O   . VAL A 1 128 ? -8.098  6.236   -10.737 1.00 11.21 ?  129  VAL A O   1 
ATOM   974  C  CB  . VAL A 1 128 ? -10.427 4.447   -11.369 1.00 9.05  ?  129  VAL A CB  1 
ATOM   975  C  CG1 . VAL A 1 128 ? -10.779 3.934   -9.962  1.00 10.16 ?  129  VAL A CG1 1 
ATOM   976  C  CG2 . VAL A 1 128 ? -11.425 3.911   -12.387 1.00 10.20 ?  129  VAL A CG2 1 
ATOM   977  N  N   . GLU A 1 129 ? -9.648  7.204   -9.414  1.00 7.77  ?  130  GLU A N   1 
ATOM   978  C  CA  . GLU A 1 129 ? -8.677  7.836   -8.536  1.00 8.93  ?  130  GLU A CA  1 
ATOM   979  C  C   . GLU A 1 129 ? -9.010  7.486   -7.095  1.00 9.42  ?  130  GLU A C   1 
ATOM   980  O  O   . GLU A 1 129 ? -10.132 7.070   -6.788  1.00 10.50 ?  130  GLU A O   1 
ATOM   981  C  CB  . GLU A 1 129 ? -8.712  9.348   -8.745  1.00 9.08  ?  130  GLU A CB  1 
ATOM   982  C  CG  . GLU A 1 129 ? -8.206  9.707   -10.148 1.00 10.43 ?  130  GLU A CG  1 
ATOM   983  C  CD  . GLU A 1 129 ? -8.266  11.185  -10.465 1.00 12.15 ?  130  GLU A CD  1 
ATOM   984  O  OE1 . GLU A 1 129 ? -8.630  12.001  -9.595  1.00 12.68 ?  130  GLU A OE1 1 
ATOM   985  O  OE2 . GLU A 1 129 ? -7.953  11.523  -11.625 1.00 13.40 -1 130  GLU A OE2 1 
ATOM   986  N  N   . ASP A 1 130 ? -8.027  7.643   -6.209  1.00 7.94  ?  131  ASP A N   1 
ATOM   987  C  CA  . ASP A 1 130 ? -8.190  7.299   -4.804  1.00 7.89  ?  131  ASP A CA  1 
ATOM   988  C  C   . ASP A 1 130 ? -8.299  8.538   -3.934  1.00 9.09  ?  131  ASP A C   1 
ATOM   989  O  O   . ASP A 1 130 ? -7.647  9.555   -4.179  1.00 8.58  ?  131  ASP A O   1 
ATOM   990  C  CB  . ASP A 1 130 ? -7.000  6.486   -4.287  1.00 7.65  ?  131  ASP A CB  1 
ATOM   991  C  CG  . ASP A 1 130 ? -6.936  5.117   -4.901  1.00 10.11 ?  131  ASP A CG  1 
ATOM   992  O  OD1 . ASP A 1 130 ? -6.128  4.933   -5.839  1.00 12.16 ?  131  ASP A OD1 1 
ATOM   993  O  OD2 . ASP A 1 130 ? -7.716  4.243   -4.475  1.00 8.46  -1 131  ASP A OD2 1 
ATOM   994  N  N   . HIS A 1 131 ? -9.101  8.421   -2.880  1.00 8.41  ?  132  HIS A N   1 
ATOM   995  C  CA  . HIS A 1 131 ? -9.117  9.408   -1.817  1.00 8.04  ?  132  HIS A CA  1 
ATOM   996  C  C   . HIS A 1 131 ? -7.911  9.214   -0.891  1.00 8.71  ?  132  HIS A C   1 
ATOM   997  O  O   . HIS A 1 131 ? -7.521  8.078   -0.585  1.00 8.64  ?  132  HIS A O   1 
ATOM   998  C  CB  . HIS A 1 131 ? -10.411 9.246   -1.018  1.00 8.05  ?  132  HIS A CB  1 
ATOM   999  C  CG  . HIS A 1 131 ? -10.455 10.065  0.226   1.00 8.34  ?  132  HIS A CG  1 
ATOM   1000 N  ND1 . HIS A 1 131 ? -10.397 9.528   1.498   1.00 7.79  ?  132  HIS A ND1 1 
ATOM   1001 C  CD2 . HIS A 1 131 ? -10.546 11.404  0.382   1.00 8.60  ?  132  HIS A CD2 1 
ATOM   1002 C  CE1 . HIS A 1 131 ? -10.456 10.510  2.381   1.00 6.91  ?  132  HIS A CE1 1 
ATOM   1003 N  NE2 . HIS A 1 131 ? -10.553 11.656  1.730   1.00 7.37  ?  132  HIS A NE2 1 
ATOM   1004 N  N   . TYR A 1 132 ? -7.311  10.329  -0.457  1.00 8.80  ?  133  TYR A N   1 
ATOM   1005 C  CA  . TYR A 1 132 ? -6.168  10.329  0.462   1.00 8.80  ?  133  TYR A CA  1 
ATOM   1006 C  C   . TYR A 1 132 ? -6.536  11.148  1.696   1.00 8.65  ?  133  TYR A C   1 
ATOM   1007 O  O   . TYR A 1 132 ? -6.434  12.381  1.687   1.00 8.69  ?  133  TYR A O   1 
ATOM   1008 C  CB  . TYR A 1 132 ? -4.923  10.897  -0.222  1.00 10.14 ?  133  TYR A CB  1 
ATOM   1009 C  CG  . TYR A 1 132 ? -4.300  9.945   -1.218  1.00 10.02 ?  133  TYR A CG  1 
ATOM   1010 C  CD1 . TYR A 1 132 ? -4.700  9.930   -2.550  1.00 12.18 ?  133  TYR A CD1 1 
ATOM   1011 C  CD2 . TYR A 1 132 ? -3.326  9.040   -0.823  1.00 11.06 ?  133  TYR A CD2 1 
ATOM   1012 C  CE1 . TYR A 1 132 ? -4.125  9.045   -3.469  1.00 11.64 ?  133  TYR A CE1 1 
ATOM   1013 C  CE2 . TYR A 1 132 ? -2.756  8.152   -1.724  1.00 12.04 ?  133  TYR A CE2 1 
ATOM   1014 C  CZ  . TYR A 1 132 ? -3.158  8.164   -3.047  1.00 11.90 ?  133  TYR A CZ  1 
ATOM   1015 O  OH  . TYR A 1 132 ? -2.586  7.288   -3.944  1.00 15.89 ?  133  TYR A OH  1 
ATOM   1016 N  N   . GLY A 1 133 ? -6.928  10.458  2.770   1.00 9.19  ?  134  GLY A N   1 
ATOM   1017 C  CA  . GLY A 1 133 ? -7.442  11.130  3.948   1.00 10.16 ?  134  GLY A CA  1 
ATOM   1018 C  C   . GLY A 1 133 ? -6.448  12.013  4.671   1.00 9.79  ?  134  GLY A C   1 
ATOM   1019 O  O   . GLY A 1 133 ? -6.867  12.941  5.374   1.00 10.75 ?  134  GLY A O   1 
ATOM   1020 N  N   . THR A 1 134 ? -5.146  11.756  4.527   1.00 10.34 ?  135  THR A N   1 
ATOM   1021 C  CA  . THR A 1 134 ? -4.181  12.601  5.228   1.00 11.15 ?  135  THR A CA  1 
ATOM   1022 C  C   . THR A 1 134 ? -3.684  13.769  4.391   1.00 15.16 ?  135  THR A C   1 
ATOM   1023 O  O   . THR A 1 134 ? -2.772  14.482  4.827   1.00 15.63 ?  135  THR A O   1 
ATOM   1024 C  CB  . THR A 1 134 ? -2.989  11.803  5.763   1.00 12.56 ?  135  THR A CB  1 
ATOM   1025 O  OG1 . THR A 1 134 ? -2.243  11.245  4.672   1.00 17.16 ?  135  THR A OG1 1 
ATOM   1026 C  CG2 . THR A 1 134 ? -3.459  10.701  6.721   1.00 17.06 ?  135  THR A CG2 1 
ATOM   1027 N  N   . ARG A 1 135 ? -4.251  13.988  3.212   1.00 9.96  ?  136  ARG A N   1 
ATOM   1028 C  CA  . ARG A 1 135 ? -3.901  15.140  2.370   1.00 10.84 ?  136  ARG A CA  1 
ATOM   1029 C  C   . ARG A 1 135 ? -5.008  16.186  2.494   1.00 8.80  ?  136  ARG A C   1 
ATOM   1030 O  O   . ARG A 1 135 ? -5.945  16.228  1.694   1.00 9.45  ?  136  ARG A O   1 
ATOM   1031 C  CB  . ARG A 1 135 ? -3.691  14.723  0.918   1.00 10.72 ?  136  ARG A CB  1 
ATOM   1032 C  CG  . ARG A 1 135 ? -2.584  13.710  0.709   1.00 12.64 ?  136  ARG A CG  1 
ATOM   1033 C  CD  . ARG A 1 135 ? -2.416  13.409  -0.760  1.00 13.02 ?  136  ARG A CD  1 
ATOM   1034 N  NE  . ARG A 1 135 ? -1.474  12.313  -0.980  1.00 14.66 ?  136  ARG A NE  1 
ATOM   1035 C  CZ  . ARG A 1 135 ? -1.203  11.801  -2.175  1.00 18.43 ?  136  ARG A CZ  1 
ATOM   1036 N  NH1 . ARG A 1 135 ? -0.326  10.812  -2.291  1.00 19.82 ?  136  ARG A NH1 1 
ATOM   1037 N  NH2 . ARG A 1 135 ? -1.813  12.278  -3.251  1.00 17.57 ?  136  ARG A NH2 1 
ATOM   1038 N  N   . LEU A 1 136 ? -4.888  17.054  3.498   1.00 9.98  ?  137  LEU A N   1 
ATOM   1039 C  CA  . LEU A 1 136 ? -5.927  18.059  3.701   1.00 8.73  ?  137  LEU A CA  1 
ATOM   1040 C  C   . LEU A 1 136 ? -6.083  18.962  2.481   1.00 10.16 ?  137  LEU A C   1 
ATOM   1041 O  O   . LEU A 1 136 ? -7.193  19.426  2.186   1.00 11.44 ?  137  LEU A O   1 
ATOM   1042 C  CB  . LEU A 1 136 ? -5.624  18.887  4.954   1.00 10.61 ?  137  LEU A CB  1 
ATOM   1043 C  CG  . LEU A 1 136 ? -6.750  19.809  5.435   1.00 10.23 ?  137  LEU A CG  1 
ATOM   1044 C  CD1 . LEU A 1 136 ? -8.042  19.035  5.715   1.00 11.69 ?  137  LEU A CD1 1 
ATOM   1045 C  CD2 . LEU A 1 136 ? -6.297  20.558  6.686   1.00 12.81 ?  137  LEU A CD2 1 
ATOM   1046 N  N   . GLU A 1 137 ? -4.992  19.187  1.746   1.00 9.88  ?  138  GLU A N   1 
ATOM   1047 C  CA  . GLU A 1 137 ? -5.018  20.077  0.594   1.00 10.94 ?  138  GLU A CA  1 
ATOM   1048 C  C   . GLU A 1 137 ? -5.893  19.543  -0.532  1.00 9.60  ?  138  GLU A C   1 
ATOM   1049 O  O   . GLU A 1 137 ? -6.238  20.306  -1.437  1.00 12.14 ?  138  GLU A O   1 
ATOM   1050 C  CB  . GLU A 1 137 ? -3.588  20.314  0.092   1.00 11.26 ?  138  GLU A CB  1 
ATOM   1051 C  CG  . GLU A 1 137 ? -2.941  19.097  -0.567  1.00 13.37 ?  138  GLU A CG  1 
ATOM   1052 C  CD  . GLU A 1 137 ? -2.258  18.135  0.408   1.00 13.18 ?  138  GLU A CD  1 
ATOM   1053 O  OE1 . GLU A 1 137 ? -1.600  17.183  -0.079  1.00 17.47 ?  138  GLU A OE1 1 
ATOM   1054 O  OE2 . GLU A 1 137 ? -2.359  18.340  1.638   1.00 16.04 -1 138  GLU A OE2 1 
ATOM   1055 N  N   . GLU A 1 138 ? -6.259  18.257  -0.496  1.00 9.84  ?  139  GLU A N   1 
ATOM   1056 C  CA  . GLU A 1 138 ? -7.142  17.657  -1.487  1.00 9.13  ?  139  GLU A CA  1 
ATOM   1057 C  C   . GLU A 1 138 ? -8.606  17.742  -1.078  1.00 7.61  ?  139  GLU A C   1 
ATOM   1058 O  O   . GLU A 1 138 ? -9.463  17.180  -1.769  1.00 9.66  ?  139  GLU A O   1 
ATOM   1059 C  CB  . GLU A 1 138 ? -6.719  16.202  -1.719  1.00 8.61  ?  139  GLU A CB  1 
ATOM   1060 C  CG  . GLU A 1 138 ? -5.307  16.128  -2.307  1.00 10.93 ?  139  GLU A CG  1 
ATOM   1061 C  CD  . GLU A 1 138 ? -4.941  14.771  -2.875  1.00 12.57 ?  139  GLU A CD  1 
ATOM   1062 O  OE1 . GLU A 1 138 ? -5.713  13.806  -2.710  1.00 12.65 ?  139  GLU A OE1 1 
ATOM   1063 O  OE2 . GLU A 1 138 ? -3.826  14.651  -3.423  1.00 14.16 -1 139  GLU A OE2 1 
ATOM   1064 N  N   . HIS A 1 139 ? -8.907  18.436  0.019   1.00 7.90  ?  140  HIS A N   1 
ATOM   1065 C  CA  . HIS A 1 139 ? -10.257 18.543  0.556   1.00 7.95  ?  140  HIS A CA  1 
ATOM   1066 C  C   . HIS A 1 139 ? -10.711 19.997  0.589   1.00 9.06  ?  140  HIS A C   1 
ATOM   1067 O  O   . HIS A 1 139 ? -9.898  20.930  0.607   1.00 10.22 ?  140  HIS A O   1 
ATOM   1068 C  CB  . HIS A 1 139 ? -10.323 17.957  1.972   1.00 8.30  ?  140  HIS A CB  1 
ATOM   1069 C  CG  . HIS A 1 139 ? -10.027 16.490  2.027   1.00 7.68  ?  140  HIS A CG  1 
ATOM   1070 N  ND1 . HIS A 1 139 ? -8.746  15.988  1.912   1.00 8.54  ?  140  HIS A ND1 1 
ATOM   1071 C  CD2 . HIS A 1 139 ? -10.843 15.419  2.177   1.00 7.00  ?  140  HIS A CD2 1 
ATOM   1072 C  CE1 . HIS A 1 139 ? -8.787  14.668  1.989   1.00 8.41  ?  140  HIS A CE1 1 
ATOM   1073 N  NE2 . HIS A 1 139 ? -10.046 14.300  2.152   1.00 8.88  ?  140  HIS A NE2 1 
ATOM   1074 N  N   . THR A 1 140 ? -12.032 20.171  0.641   1.00 8.20  ?  141  THR A N   1 
ATOM   1075 C  CA  . THR A 1 140 ? -12.673 21.473  0.744   1.00 8.39  ?  141  THR A CA  1 
ATOM   1076 C  C   . THR A 1 140 ? -13.457 21.540  2.050   1.00 8.64  ?  141  THR A C   1 
ATOM   1077 O  O   . THR A 1 140 ? -14.158 20.588  2.426   1.00 8.83  ?  141  THR A O   1 
ATOM   1078 C  CB  . THR A 1 140 ? -13.618 21.674  -0.444  1.00 10.51 ?  141  THR A CB  1 
ATOM   1079 O  OG1 . THR A 1 140 ? -12.849 21.701  -1.649  1.00 14.57 ?  141  THR A OG1 1 
ATOM   1080 C  CG2 . THR A 1 140 ? -14.368 23.007  -0.334  1.00 12.03 ?  141  THR A CG2 1 
ATOM   1081 N  N   . TYR A 1 141 ? -13.329 22.666  2.747   1.00 9.91  ?  142  TYR A N   1 
ATOM   1082 C  CA  . TYR A 1 141 ? -14.022 22.881  4.007   1.00 8.11  ?  142  TYR A CA  1 
ATOM   1083 C  C   . TYR A 1 141 ? -15.443 23.325  3.717   1.00 9.93  ?  142  TYR A C   1 
ATOM   1084 O  O   . TYR A 1 141 ? -15.658 24.280  2.967   1.00 11.02 ?  142  TYR A O   1 
ATOM   1085 C  CB  . TYR A 1 141 ? -13.313 23.987  4.794   1.00 9.23  ?  142  TYR A CB  1 
ATOM   1086 C  CG  . TYR A 1 141 ? -14.035 24.381  6.069   1.00 8.28  ?  142  TYR A CG  1 
ATOM   1087 C  CD1 . TYR A 1 141 ? -14.114 23.500  7.144   1.00 9.30  ?  142  TYR A CD1 1 
ATOM   1088 C  CD2 . TYR A 1 141 ? -14.627 25.633  6.203   1.00 8.97  ?  142  TYR A CD2 1 
ATOM   1089 C  CE1 . TYR A 1 141 ? -14.764 23.851  8.316   1.00 11.16 ?  142  TYR A CE1 1 
ATOM   1090 C  CE2 . TYR A 1 141 ? -15.270 25.998  7.377   1.00 8.94  ?  142  TYR A CE2 1 
ATOM   1091 C  CZ  . TYR A 1 141 ? -15.337 25.105  8.433   1.00 9.50  ?  142  TYR A CZ  1 
ATOM   1092 O  OH  . TYR A 1 141 ? -15.979 25.457  9.605   1.00 11.34 ?  142  TYR A OH  1 
ATOM   1093 N  N   . LEU A 1 142 ? -16.412 22.647  4.328   1.00 10.26 ?  143  LEU A N   1 
ATOM   1094 C  CA  . LEU A 1 142 ? -17.824 22.903  4.082   1.00 10.32 ?  143  LEU A CA  1 
ATOM   1095 C  C   . LEU A 1 142 ? -18.545 23.539  5.262   1.00 12.55 ?  143  LEU A C   1 
ATOM   1096 O  O   . LEU A 1 142 ? -19.716 23.916  5.126   1.00 16.47 ?  143  LEU A O   1 
ATOM   1097 C  CB  . LEU A 1 142 ? -18.524 21.593  3.709   1.00 10.68 ?  143  LEU A CB  1 
ATOM   1098 C  CG  . LEU A 1 142 ? -17.907 20.823  2.545   1.00 12.76 ?  143  LEU A CG  1 
ATOM   1099 C  CD1 . LEU A 1 142 ? -18.738 19.592  2.267   1.00 15.09 ?  143  LEU A CD1 1 
ATOM   1100 C  CD2 . LEU A 1 142 ? -17.803 21.668  1.292   1.00 15.01 ?  143  LEU A CD2 1 
ATOM   1101 N  N   . GLY A 1 143 ? -17.891 23.673  6.404   1.00 9.10  ?  144  GLY A N   1 
ATOM   1102 C  CA  . GLY A 1 143 ? -18.536 24.117  7.620   1.00 9.99  ?  144  GLY A CA  1 
ATOM   1103 C  C   . GLY A 1 143 ? -18.210 23.185  8.763   1.00 10.13 ?  144  GLY A C   1 
ATOM   1104 O  O   . GLY A 1 143 ? -17.545 22.164  8.598   1.00 10.54 ?  144  GLY A O   1 
ATOM   1105 N  N   . THR A 1 144 ? -18.690 23.554  9.949   1.00 10.44 ?  145  THR A N   1 
ATOM   1106 C  CA  . THR A 1 144 ? -18.494 22.759  11.154  1.00 10.31 ?  145  THR A CA  1 
ATOM   1107 C  C   . THR A 1 144 ? -19.861 22.438  11.748  1.00 11.90 ?  145  THR A C   1 
ATOM   1108 O  O   . THR A 1 144 ? -20.749 23.295  11.771  1.00 11.45 ?  145  THR A O   1 
ATOM   1109 C  CB  . THR A 1 144 ? -17.625 23.541  12.160  1.00 11.92 ?  145  THR A CB  1 
ATOM   1110 O  OG1 . THR A 1 144 ? -16.312 23.709  11.607  1.00 12.56 ?  145  THR A OG1 1 
ATOM   1111 C  CG2 . THR A 1 144 ? -17.492 22.777  13.485  1.00 11.74 ?  145  THR A CG2 1 
ATOM   1112 N  N   . THR A 1 145 ? -20.047 21.185  12.189  1.00 10.42 ?  146  THR A N   1 
ATOM   1113 C  CA  . THR A 1 145 ? -21.342 20.755  12.703  1.00 10.76 ?  146  THR A CA  1 
ATOM   1114 C  C   . THR A 1 145 ? -21.621 21.401  14.057  1.00 11.55 ?  146  THR A C   1 
ATOM   1115 O  O   . THR A 1 145 ? -20.720 21.953  14.694  1.00 11.72 ?  146  THR A O   1 
ATOM   1116 C  CB  . THR A 1 145 ? -21.377 19.236  12.883  1.00 11.13 ?  146  THR A CB  1 
ATOM   1117 O  OG1 . THR A 1 145 ? -20.490 18.866  13.945  1.00 10.29 ?  146  THR A OG1 1 
ATOM   1118 C  CG2 . THR A 1 145 ? -21.007 18.503  11.585  1.00 11.45 ?  146  THR A CG2 1 
ATOM   1119 N  N   . PRO A 1 146 ? -22.872 21.335  14.526  1.00 11.61 ?  147  PRO A N   1 
ATOM   1120 C  CA  . PRO A 1 146 ? -23.185 21.871  15.858  1.00 13.27 ?  147  PRO A CA  1 
ATOM   1121 C  C   . PRO A 1 146 ? -22.405 21.217  16.976  1.00 12.82 ?  147  PRO A C   1 
ATOM   1122 O  O   . PRO A 1 146 ? -22.301 21.801  18.059  1.00 17.07 ?  147  PRO A O   1 
ATOM   1123 C  CB  . PRO A 1 146 ? -24.687 21.596  15.993  1.00 17.24 ?  147  PRO A CB  1 
ATOM   1124 C  CG  . PRO A 1 146 ? -25.176 21.662  14.571  1.00 16.40 ?  147  PRO A CG  1 
ATOM   1125 C  CD  . PRO A 1 146 ? -24.096 20.944  13.800  1.00 12.36 ?  147  PRO A CD  1 
ATOM   1126 N  N   . ASN A 1 147 ? -21.876 20.015  16.771  1.00 12.31 ?  148  ASN A N   1 
ATOM   1127 C  CA  . ASN A 1 147 ? -21.064 19.362  17.782  1.00 10.88 ?  148  ASN A CA  1 
ATOM   1128 C  C   . ASN A 1 147 ? -19.575 19.538  17.548  1.00 11.80 ?  148  ASN A C   1 
ATOM   1129 O  O   . ASN A 1 147 ? -18.769 18.852  18.182  1.00 14.56 ?  148  ASN A O   1 
ATOM   1130 C  CB  . ASN A 1 147 ? -21.454 17.894  17.912  1.00 14.10 ?  148  ASN A CB  1 
ATOM   1131 C  CG  . ASN A 1 147 ? -22.796 17.729  18.581  1.00 14.28 ?  148  ASN A CG  1 
ATOM   1132 O  OD1 . ASN A 1 147 ? -23.826 17.703  17.920  1.00 16.39 ?  148  ASN A OD1 1 
ATOM   1133 N  ND2 . ASN A 1 147 ? -22.788 17.607  19.901  1.00 17.40 ?  148  ASN A ND2 1 
ATOM   1134 N  N   . GLY A 1 148 ? -19.195 20.446  16.655  1.00 10.36 ?  149  GLY A N   1 
ATOM   1135 C  CA  . GLY A 1 148 ? -17.822 20.886  16.571  1.00 12.33 ?  149  GLY A CA  1 
ATOM   1136 C  C   . GLY A 1 148 ? -16.934 20.114  15.634  1.00 12.11 ?  149  GLY A C   1 
ATOM   1137 O  O   . GLY A 1 148 ? -15.711 20.261  15.707  1.00 16.43 ?  149  GLY A O   1 
ATOM   1138 N  N   . VAL A 1 149 ? -17.483 19.287  14.755  1.00 10.35 ?  150  VAL A N   1 
ATOM   1139 C  CA  . VAL A 1 149 ? -16.677 18.514  13.817  1.00 10.98 ?  150  VAL A CA  1 
ATOM   1140 C  C   . VAL A 1 149 ? -16.596 19.295  12.510  1.00 9.80  ?  150  VAL A C   1 
ATOM   1141 O  O   . VAL A 1 149 ? -17.645 19.559  11.892  1.00 11.25 ?  150  VAL A O   1 
ATOM   1142 C  CB  . VAL A 1 149 ? -17.245 17.110  13.595  1.00 8.60  ?  150  VAL A CB  1 
ATOM   1143 C  CG1 . VAL A 1 149 ? -16.369 16.351  12.609  1.00 11.29 ?  150  VAL A CG1 1 
ATOM   1144 C  CG2 . VAL A 1 149 ? -17.342 16.359  14.932  1.00 11.39 ?  150  VAL A CG2 1 
ATOM   1145 N  N   . PRO A 1 150 ? -15.408 19.684  12.060  1.00 9.93  ?  151  PRO A N   1 
ATOM   1146 C  CA  . PRO A 1 150 ? -15.301 20.368  10.768  1.00 9.80  ?  151  PRO A CA  1 
ATOM   1147 C  C   . PRO A 1 150 ? -15.449 19.353  9.648   1.00 9.73  ?  151  PRO A C   1 
ATOM   1148 O  O   . PRO A 1 150 ? -14.998 18.211  9.762   1.00 11.43 ?  151  PRO A O   1 
ATOM   1149 C  CB  . PRO A 1 150 ? -13.884 20.954  10.806  1.00 10.56 ?  151  PRO A CB  1 
ATOM   1150 C  CG  . PRO A 1 150 ? -13.115 19.946  11.597  1.00 12.22 ?  151  PRO A CG  1 
ATOM   1151 C  CD  . PRO A 1 150 ? -14.085 19.470  12.682  1.00 11.43 ?  151  PRO A CD  1 
ATOM   1152 N  N   . ALA A 1 151 ? -16.127 19.762  8.578   1.00 9.13  ?  152  ALA A N   1 
ATOM   1153 C  CA  . ALA A 1 151 ? -16.421 18.885  7.449   1.00 8.27  ?  152  ALA A CA  1 
ATOM   1154 C  C   . ALA A 1 151 ? -15.447 19.211  6.324   1.00 8.71  ?  152  ALA A C   1 
ATOM   1155 O  O   . ALA A 1 151 ? -15.550 20.265  5.692   1.00 10.42 ?  152  ALA A O   1 
ATOM   1156 C  CB  . ALA A 1 151 ? -17.868 19.068  6.996   1.00 10.97 ?  152  ALA A CB  1 
ATOM   1157 N  N   . TRP A 1 152 ? -14.511 18.303  6.072   1.00 8.11  ?  153  TRP A N   1 
ATOM   1158 C  CA  . TRP A 1 152 ? -13.509 18.457  5.026   1.00 9.37  ?  153  TRP A CA  1 
ATOM   1159 C  C   . TRP A 1 152 ? -13.697 17.298  4.055   1.00 8.03  ?  153  TRP A C   1 
ATOM   1160 O  O   . TRP A 1 152 ? -13.420 16.145  4.406   1.00 9.00  ?  153  TRP A O   1 
ATOM   1161 C  CB  . TRP A 1 152 ? -12.107 18.400  5.631   1.00 8.74  ?  153  TRP A CB  1 
ATOM   1162 C  CG  . TRP A 1 152 ? -11.694 19.605  6.432   1.00 8.02  ?  153  TRP A CG  1 
ATOM   1163 C  CD1 . TRP A 1 152 ? -11.828 19.789  7.784   1.00 9.74  ?  153  TRP A CD1 1 
ATOM   1164 C  CD2 . TRP A 1 152 ? -11.062 20.781  5.926   1.00 9.46  ?  153  TRP A CD2 1 
ATOM   1165 N  NE1 . TRP A 1 152 ? -11.312 21.017  8.143   1.00 11.11 ?  153  TRP A NE1 1 
ATOM   1166 C  CE2 . TRP A 1 152 ? -10.831 21.639  7.020   1.00 9.99  ?  153  TRP A CE2 1 
ATOM   1167 C  CE3 . TRP A 1 152 ? -10.660 21.190  4.650   1.00 10.85 ?  153  TRP A CE3 1 
ATOM   1168 C  CZ2 . TRP A 1 152 ? -10.215 22.886  6.874   1.00 10.57 ?  153  TRP A CZ2 1 
ATOM   1169 C  CZ3 . TRP A 1 152 ? -10.052 22.418  4.508   1.00 13.08 ?  153  TRP A CZ3 1 
ATOM   1170 C  CH2 . TRP A 1 152 ? -9.838  23.248  5.604   1.00 10.80 ?  153  TRP A CH2 1 
ATOM   1171 N  N   . ILE A 1 153 ? -14.157 17.597  2.841   1.00 7.98  ?  154  ILE A N   1 
ATOM   1172 C  CA  . ILE A 1 153 ? -14.601 16.570  1.904   1.00 9.58  ?  154  ILE A CA  1 
ATOM   1173 C  C   . ILE A 1 153 ? -13.821 16.703  0.605   1.00 7.24  ?  154  ILE A C   1 
ATOM   1174 O  O   . ILE A 1 153 ? -13.498 17.813  0.174   1.00 8.51  ?  154  ILE A O   1 
ATOM   1175 C  CB  . ILE A 1 153 ? -16.126 16.675  1.676   1.00 7.74  ?  154  ILE A CB  1 
ATOM   1176 C  CG1 . ILE A 1 153 ? -16.866 16.514  3.015   1.00 9.07  ?  154  ILE A CG1 1 
ATOM   1177 C  CG2 . ILE A 1 153 ? -16.621 15.672  0.659   1.00 8.23  ?  154  ILE A CG2 1 
ATOM   1178 C  CD1 . ILE A 1 153 ? -16.684 15.187  3.688   1.00 10.41 ?  154  ILE A CD1 1 
ATOM   1179 N  N   . ASP A 1 154 ? -13.529 15.569  -0.027  1.00 7.34  ?  155  ASP A N   1 
ATOM   1180 C  CA  . ASP A 1 154 ? -12.629 15.552  -1.177  1.00 7.44  ?  155  ASP A CA  1 
ATOM   1181 C  C   . ASP A 1 154 ? -13.119 16.525  -2.246  1.00 8.99  ?  155  ASP A C   1 
ATOM   1182 O  O   . ASP A 1 154 ? -14.286 16.495  -2.653  1.00 7.49  ?  155  ASP A O   1 
ATOM   1183 C  CB  . ASP A 1 154 ? -12.567 14.128  -1.738  1.00 7.84  ?  155  ASP A CB  1 
ATOM   1184 C  CG  . ASP A 1 154 ? -11.485 13.955  -2.800  1.00 8.39  ?  155  ASP A CG  1 
ATOM   1185 O  OD1 . ASP A 1 154 ? -11.541 14.573  -3.892  1.00 8.56  ?  155  ASP A OD1 1 
ATOM   1186 O  OD2 . ASP A 1 154 ? -10.536 13.195  -2.519  1.00 10.03 -1 155  ASP A OD2 1 
ATOM   1187 N  N   . SER A 1 155 ? -12.210 17.390  -2.703  1.00 7.22  ?  156  SER A N   1 
ATOM   1188 C  CA  . SER A 1 155 ? -12.593 18.472  -3.615  1.00 8.68  ?  156  SER A CA  1 
ATOM   1189 C  C   . SER A 1 155 ? -13.128 17.976  -4.959  1.00 8.26  ?  156  SER A C   1 
ATOM   1190 O  O   . SER A 1 155 ? -13.925 18.674  -5.599  1.00 8.93  ?  156  SER A O   1 
ATOM   1191 C  CB  . SER A 1 155 ? -11.416 19.429  -3.813  1.00 9.07  ?  156  SER A CB  1 
ATOM   1192 O  OG  . SER A 1 155 ? -11.006 19.942  -2.553  1.00 11.02 ?  156  SER A OG  1 
ATOM   1193 N  N   . ARG A 1 156 ? -12.693 16.801  -5.420  1.00 7.58  ?  157  ARG A N   1 
ATOM   1194 C  CA  . ARG A 1 156 ? -13.177 16.301  -6.707  1.00 7.79  ?  157  ARG A CA  1 
ATOM   1195 C  C   . ARG A 1 156 ? -14.660 15.968  -6.645  1.00 9.10  ?  157  ARG A C   1 
ATOM   1196 O  O   . ARG A 1 156 ? -15.377 16.097  -7.645  1.00 12.99 ?  157  ARG A O   1 
ATOM   1197 C  CB  . ARG A 1 156 ? -12.381 15.061  -7.109  1.00 9.53  ?  157  ARG A CB  1 
ATOM   1198 C  CG  . ARG A 1 156 ? -10.912 15.354  -7.409  1.00 8.88  ?  157  ARG A CG  1 
ATOM   1199 C  CD  . ARG A 1 156 ? -10.112 14.060  -7.459  1.00 9.74  ?  157  ARG A CD  1 
ATOM   1200 N  NE  . ARG A 1 156 ? -9.915  13.516  -6.119  1.00 9.81  ?  157  ARG A NE  1 
ATOM   1201 C  CZ  . ARG A 1 156 ? -8.981  12.624  -5.801  1.00 8.99  ?  157  ARG A CZ  1 
ATOM   1202 N  NH1 . ARG A 1 156 ? -8.179  12.123  -6.737  1.00 10.37 ?  157  ARG A NH1 1 
ATOM   1203 N  NH2 . ARG A 1 156 ? -8.849  12.236  -4.541  1.00 9.05  ?  157  ARG A NH2 1 
ATOM   1204 N  N   . TYR A 1 157 ? -15.142 15.563  -5.478  1.00 8.32  ?  158  TYR A N   1 
ATOM   1205 C  CA  . TYR A 1 157 ? -16.566 15.325  -5.292  1.00 8.29  ?  158  TYR A CA  1 
ATOM   1206 C  C   . TYR A 1 157 ? -17.319 16.634  -5.072  1.00 8.62  ?  158  TYR A C   1 
ATOM   1207 O  O   . TYR A 1 157 ? -18.368 16.854  -5.688  1.00 8.60  ?  158  TYR A O   1 
ATOM   1208 C  CB  . TYR A 1 157 ? -16.746 14.391  -4.105  1.00 9.28  ?  158  TYR A CB  1 
ATOM   1209 C  CG  . TYR A 1 157 ? -18.170 14.051  -3.751  1.00 6.42  ?  158  TYR A CG  1 
ATOM   1210 C  CD1 . TYR A 1 157 ? -18.818 12.998  -4.371  1.00 8.00  ?  158  TYR A CD1 1 
ATOM   1211 C  CD2 . TYR A 1 157 ? -18.853 14.763  -2.759  1.00 7.09  ?  158  TYR A CD2 1 
ATOM   1212 C  CE1 . TYR A 1 157 ? -20.113 12.647  -4.025  1.00 7.14  ?  158  TYR A CE1 1 
ATOM   1213 C  CE2 . TYR A 1 157 ? -20.157 14.428  -2.404  1.00 6.99  ?  158  TYR A CE2 1 
ATOM   1214 C  CZ  . TYR A 1 157 ? -20.776 13.368  -3.044  1.00 7.69  ?  158  TYR A CZ  1 
ATOM   1215 O  OH  . TYR A 1 157 ? -22.061 12.997  -2.707  1.00 7.79  ?  158  TYR A OH  1 
ATOM   1216 N  N   . VAL A 1 158 ? -16.783 17.511  -4.218  1.00 7.74  ?  159  VAL A N   1 
ATOM   1217 C  CA  . VAL A 1 158 ? -17.427 18.802  -3.961  1.00 8.62  ?  159  VAL A CA  1 
ATOM   1218 C  C   . VAL A 1 158 ? -17.634 19.583  -5.254  1.00 10.56 ?  159  VAL A C   1 
ATOM   1219 O  O   . VAL A 1 158 ? -18.694 20.183  -5.465  1.00 9.91  ?  159  VAL A O   1 
ATOM   1220 C  CB  . VAL A 1 158 ? -16.624 19.606  -2.920  1.00 9.16  ?  159  VAL A CB  1 
ATOM   1221 C  CG1 . VAL A 1 158 ? -17.155 21.044  -2.795  1.00 11.88 ?  159  VAL A CG1 1 
ATOM   1222 C  CG2 . VAL A 1 158 ? -16.688 18.900  -1.579  1.00 11.73 ?  159  VAL A CG2 1 
ATOM   1223 N  N   . GLN A 1 159 ? -16.640 19.577  -6.139  1.00 8.52  ?  160  GLN A N   1 
ATOM   1224 C  CA  . GLN A 1 159 ? -16.673 20.348  -7.379  1.00 8.54  ?  160  GLN A CA  1 
ATOM   1225 C  C   . GLN A 1 159 ? -17.481 19.688  -8.490  1.00 11.27 ?  160  GLN A C   1 
ATOM   1226 O  O   . GLN A 1 159 ? -17.791 20.358  -9.484  1.00 11.45 ?  160  GLN A O   1 
ATOM   1227 C  CB  . GLN A 1 159 ? -15.239 20.600  -7.858  1.00 10.57 ?  160  GLN A CB  1 
ATOM   1228 C  CG  . GLN A 1 159 ? -14.490 21.592  -6.988  1.00 12.07 ?  160  GLN A CG  1 
ATOM   1229 C  CD  . GLN A 1 159 ? -13.001 21.606  -7.257  1.00 14.59 ?  160  GLN A CD  1 
ATOM   1230 O  OE1 . GLN A 1 159 ? -12.545 21.177  -8.319  1.00 20.46 ?  160  GLN A OE1 1 
ATOM   1231 N  NE2 . GLN A 1 159 ? -12.232 22.125  -6.305  1.00 15.05 ?  160  GLN A NE2 1 
ATOM   1232 N  N   . ALA A 1 160 ? -17.840 18.412  -8.357  1.00 9.00  ?  161  ALA A N   1 
ATOM   1233 C  CA  . ALA A 1 160 ? -18.597 17.748  -9.411  1.00 8.97  ?  161  ALA A CA  1 
ATOM   1234 C  C   . ALA A 1 160 ? -20.038 18.248  -9.443  1.00 10.05 ?  161  ALA A C   1 
ATOM   1235 O  O   . ALA A 1 160 ? -20.665 18.445  -8.398  1.00 10.78 ?  161  ALA A O   1 
ATOM   1236 C  CB  . ALA A 1 160 ? -18.590 16.230  -9.180  1.00 9.85  ?  161  ALA A CB  1 
ATOM   1237 N  N   . ASP A 1 161 ? -20.572 18.444  -10.656 1.00 9.88  ?  162  ASP A N   1 
ATOM   1238 C  CA  . ASP A 1 161 ? -21.954 18.912  -10.783 1.00 10.78 ?  162  ASP A CA  1 
ATOM   1239 C  C   . ASP A 1 161 ? -22.943 17.846  -10.339 1.00 9.19  ?  162  ASP A C   1 
ATOM   1240 O  O   . ASP A 1 161 ? -24.006 18.171  -9.805  1.00 13.68 ?  162  ASP A O   1 
ATOM   1241 C  CB  . ASP A 1 161 ? -22.281 19.273  -12.239 1.00 12.29 ?  162  ASP A CB  1 
ATOM   1242 C  CG  . ASP A 1 161 ? -21.545 20.486  -12.735 1.00 25.31 ?  162  ASP A CG  1 
ATOM   1243 O  OD1 . ASP A 1 161 ? -21.088 21.301  -11.913 1.00 25.50 ?  162  ASP A OD1 1 
ATOM   1244 O  OD2 . ASP A 1 161 ? -21.444 20.622  -13.975 1.00 36.58 -1 162  ASP A OD2 1 
ATOM   1245 N  N   . LEU A 1 162 ? -22.625 16.577  -10.580 1.00 8.09  ?  163  LEU A N   1 
ATOM   1246 C  CA  . LEU A 1 162 ? -23.495 15.447  -10.277 1.00 8.61  ?  163  LEU A CA  1 
ATOM   1247 C  C   . LEU A 1 162 ? -22.734 14.527  -9.333  1.00 8.64  ?  163  LEU A C   1 
ATOM   1248 O  O   . LEU A 1 162 ? -21.641 14.059  -9.669  1.00 9.05  ?  163  LEU A O   1 
ATOM   1249 C  CB  . LEU A 1 162 ? -23.865 14.708  -11.564 1.00 9.36  ?  163  LEU A CB  1 
ATOM   1250 C  CG  . LEU A 1 162 ? -24.837 13.538  -11.374 1.00 10.25 ?  163  LEU A CG  1 
ATOM   1251 C  CD1 . LEU A 1 162 ? -26.158 13.984  -10.761 1.00 11.74 ?  163  LEU A CD1 1 
ATOM   1252 C  CD2 . LEU A 1 162 ? -25.078 12.835  -12.705 1.00 12.39 ?  163  LEU A CD2 1 
ATOM   1253 N  N   . LYS A 1 163 ? -23.303 14.285  -8.154  1.00 7.91  ?  164  LYS A N   1 
ATOM   1254 C  CA  . LYS A 1 163 ? -22.667 13.519  -7.081  1.00 7.82  ?  164  LYS A CA  1 
ATOM   1255 C  C   . LYS A 1 163 ? -23.435 12.216  -6.879  1.00 8.62  ?  164  LYS A C   1 
ATOM   1256 O  O   . LYS A 1 163 ? -24.629 12.241  -6.556  1.00 8.99  ?  164  LYS A O   1 
ATOM   1257 C  CB  . LYS A 1 163 ? -22.694 14.325  -5.780  1.00 8.30  ?  164  LYS A CB  1 
ATOM   1258 C  CG  . LYS A 1 163 ? -21.810 15.569  -5.777  1.00 7.42  ?  164  LYS A CG  1 
ATOM   1259 C  CD  . LYS A 1 163 ? -22.219 16.501  -4.631  1.00 9.31  ?  164  LYS A CD  1 
ATOM   1260 C  CE  . LYS A 1 163 ? -21.203 17.629  -4.412  1.00 9.78  ?  164  LYS A CE  1 
ATOM   1261 N  NZ  . LYS A 1 163 ? -21.122 18.527  -5.603  1.00 12.51 ?  164  LYS A NZ  1 
ATOM   1262 N  N   . ILE A 1 164 ? -22.754 11.084  -7.050  1.00 7.16  ?  165  ILE A N   1 
ATOM   1263 C  CA  . ILE A 1 164 ? -23.380 9.769   -6.973  1.00 7.12  ?  165  ILE A CA  1 
ATOM   1264 C  C   . ILE A 1 164 ? -22.562 8.917   -6.012  1.00 7.34  ?  165  ILE A C   1 
ATOM   1265 O  O   . ILE A 1 164 ? -21.328 9.012   -5.989  1.00 8.00  ?  165  ILE A O   1 
ATOM   1266 C  CB  . ILE A 1 164 ? -23.465 9.100   -8.372  1.00 7.57  ?  165  ILE A CB  1 
ATOM   1267 C  CG1 . ILE A 1 164 ? -24.270 9.969   -9.344  1.00 9.32  ?  165  ILE A CG1 1 
ATOM   1268 C  CG2 . ILE A 1 164 ? -24.034 7.688   -8.288  1.00 8.49  ?  165  ILE A CG2 1 
ATOM   1269 C  CD1 . ILE A 1 164 ? -24.120 9.553   -10.804 1.00 10.80 ?  165  ILE A CD1 1 
ATOM   1270 N  N   . ALA A 1 165 ? -23.232 8.084   -5.216  1.00 7.93  ?  166  ALA A N   1 
ATOM   1271 C  CA  . ALA A 1 165 ? -22.510 7.161   -4.346  1.00 8.07  ?  166  ALA A CA  1 
ATOM   1272 C  C   . ALA A 1 165 ? -23.084 5.756   -4.460  1.00 9.66  ?  166  ALA A C   1 
ATOM   1273 O  O   . ALA A 1 165 ? -24.300 5.576   -4.586  1.00 12.12 ?  166  ALA A O   1 
ATOM   1274 C  CB  . ALA A 1 165 ? -22.529 7.630   -2.874  1.00 8.78  ?  166  ALA A CB  1 
ATOM   1275 N  N   . THR A 1 166 ? -22.206 4.757   -4.427  1.00 7.96  ?  167  THR A N   1 
ATOM   1276 C  CA  . THR A 1 166 ? -22.603 3.355   -4.475  1.00 7.43  ?  167  THR A CA  1 
ATOM   1277 C  C   . THR A 1 166 ? -22.084 2.646   -3.231  1.00 8.65  ?  167  THR A C   1 
ATOM   1278 O  O   . THR A 1 166 ? -21.108 3.081   -2.606  1.00 12.19 ?  167  THR A O   1 
ATOM   1279 C  CB  . THR A 1 166 ? -22.023 2.661   -5.716  1.00 8.74  ?  167  THR A CB  1 
ATOM   1280 O  OG1 . THR A 1 166 ? -20.590 2.647   -5.639  1.00 8.38  ?  167  THR A OG1 1 
ATOM   1281 C  CG2 . THR A 1 166 ? -22.469 3.366   -7.006  1.00 9.98  ?  167  THR A CG2 1 
ATOM   1282 N  N   . GLY A 1 167 ? -22.706 1.531   -2.869  1.00 7.19  ?  168  GLY A N   1 
ATOM   1283 C  CA  . GLY A 1 167 ? -22.233 0.853   -1.676  1.00 9.25  ?  168  GLY A CA  1 
ATOM   1284 C  C   . GLY A 1 167 ? -23.078 -0.337  -1.288  1.00 7.01  ?  168  GLY A C   1 
ATOM   1285 O  O   . GLY A 1 167 ? -23.952 -0.800  -2.033  1.00 7.60  ?  168  GLY A O   1 
ATOM   1286 N  N   . LEU A 1 168 ? -22.804 -0.796  -0.071  1.00 7.64  ?  169  LEU A N   1 
ATOM   1287 C  CA  . LEU A 1 168 ? -23.247 -2.093  0.420   1.00 6.84  ?  169  LEU A CA  1 
ATOM   1288 C  C   . LEU A 1 168 ? -23.671 -1.926  1.875   1.00 9.03  ?  169  LEU A C   1 
ATOM   1289 O  O   . LEU A 1 168 ? -22.908 -1.402  2.704   1.00 9.28  ?  169  LEU A O   1 
ATOM   1290 C  CB  . LEU A 1 168 ? -22.101 -3.102  0.328   1.00 8.09  ?  169  LEU A CB  1 
ATOM   1291 C  CG  . LEU A 1 168 ? -22.138 -4.371  1.165   1.00 9.33  ?  169  LEU A CG  1 
ATOM   1292 C  CD1 . LEU A 1 168 ? -23.296 -5.273  0.709   1.00 10.84 ?  169  LEU A CD1 1 
ATOM   1293 C  CD2 . LEU A 1 168 ? -20.794 -5.085  1.063   1.00 10.68 ?  169  LEU A CD2 1 
ATOM   1294 N  N   . ILE A 1 169 ? -24.892 -2.357  2.185   1.00 7.23  ?  170  ILE A N   1 
ATOM   1295 C  CA  . ILE A 1 169 ? -25.467 -2.206  3.518   1.00 7.49  ?  170  ILE A CA  1 
ATOM   1296 C  C   . ILE A 1 169 ? -25.198 -3.478  4.306   1.00 7.89  ?  170  ILE A C   1 
ATOM   1297 O  O   . ILE A 1 169 ? -25.818 -4.515  4.040   1.00 8.80  ?  170  ILE A O   1 
ATOM   1298 C  CB  . ILE A 1 169 ? -26.963 -1.872  3.447   1.00 7.32  ?  170  ILE A CB  1 
ATOM   1299 C  CG1 . ILE A 1 169 ? -27.145 -0.534  2.733   1.00 8.29  ?  170  ILE A CG1 1 
ATOM   1300 C  CG2 . ILE A 1 169 ? -27.582 -1.827  4.843   1.00 10.18 ?  170  ILE A CG2 1 
ATOM   1301 C  CD1 . ILE A 1 169 ? -28.596 -0.188  2.353   1.00 9.75  ?  170  ILE A CD1 1 
ATOM   1302 N  N   . GLU A 1 170 ? -24.272 -3.401  5.256   1.00 7.76  ?  171  GLU A N   1 
ATOM   1303 C  CA  . GLU A 1 170 ? -23.900 -4.491  6.150   1.00 8.75  ?  171  GLU A CA  1 
ATOM   1304 C  C   . GLU A 1 170 ? -23.795 -3.895  7.543   1.00 8.70  ?  171  GLU A C   1 
ATOM   1305 O  O   . GLU A 1 170 ? -23.614 -2.681  7.681   1.00 8.08  ?  171  GLU A O   1 
ATOM   1306 C  CB  . GLU A 1 170 ? -22.515 -5.043  5.772   1.00 9.95  ?  171  GLU A CB  1 
ATOM   1307 C  CG  . GLU A 1 170 ? -22.473 -5.834  4.480   1.00 9.15  ?  171  GLU A CG  1 
ATOM   1308 C  CD  . GLU A 1 170 ? -22.983 -7.243  4.588   1.00 10.49 ?  171  GLU A CD  1 
ATOM   1309 O  OE1 . GLU A 1 170 ? -22.754 -8.019  3.629   1.00 10.72 ?  171  GLU A OE1 1 
ATOM   1310 O  OE2 . GLU A 1 170 ? -23.615 -7.584  5.598   1.00 10.60 -1 171  GLU A OE2 1 
ATOM   1311 N  N   . PRO A 1 171 ? -23.864 -4.710  8.597   1.00 7.35  ?  172  PRO A N   1 
ATOM   1312 C  CA  . PRO A 1 171 ? -23.620 -4.167  9.944   1.00 7.80  ?  172  PRO A CA  1 
ATOM   1313 C  C   . PRO A 1 171 ? -22.243 -3.527  10.022  1.00 8.49  ?  172  PRO A C   1 
ATOM   1314 O  O   . PRO A 1 171 ? -21.303 -3.930  9.330   1.00 9.32  ?  172  PRO A O   1 
ATOM   1315 C  CB  . PRO A 1 171 ? -23.701 -5.402  10.855  1.00 8.01  ?  172  PRO A CB  1 
ATOM   1316 C  CG  . PRO A 1 171 ? -24.524 -6.390  10.067  1.00 8.86  ?  172  PRO A CG  1 
ATOM   1317 C  CD  . PRO A 1 171 ? -24.161 -6.156  8.628   1.00 9.75  ?  172  PRO A CD  1 
ATOM   1318 N  N   . HIS A 1 172 ? -22.131 -2.503  10.871  1.00 7.90  ?  173  HIS A N   1 
ATOM   1319 C  CA  . HIS A 1 172 ? -20.871 -1.797  11.067  1.00 6.54  ?  173  HIS A CA  1 
ATOM   1320 C  C   . HIS A 1 172 ? -20.688 -1.484  12.545  1.00 7.23  ?  173  HIS A C   1 
ATOM   1321 O  O   . HIS A 1 172 ? -21.601 -0.948  13.184  1.00 7.87  ?  173  HIS A O   1 
ATOM   1322 C  CB  . HIS A 1 172 ? -20.814 -0.491  10.273  1.00 7.06  ?  173  HIS A CB  1 
ATOM   1323 C  CG  . HIS A 1 172 ? -19.443 0.113   10.252  1.00 6.27  ?  173  HIS A CG  1 
ATOM   1324 N  ND1 . HIS A 1 172 ? -19.000 1.002   11.215  1.00 6.97  ?  173  HIS A ND1 1 
ATOM   1325 C  CD2 . HIS A 1 172 ? -18.397 -0.091  9.415   1.00 7.31  ?  173  HIS A CD2 1 
ATOM   1326 C  CE1 . HIS A 1 172 ? -17.745 1.328   10.959  1.00 7.21  ?  173  HIS A CE1 1 
ATOM   1327 N  NE2 . HIS A 1 172 ? -17.354 0.674   9.876   1.00 7.64  ?  173  HIS A NE2 1 
ATOM   1328 N  N   . LEU A 1 173 ? -19.481 -1.742  13.056  1.00 7.36  ?  174  LEU A N   1 
ATOM   1329 C  CA  . LEU A 1 173 ? -19.223 -1.737  14.496  1.00 7.45  ?  174  LEU A CA  1 
ATOM   1330 C  C   . LEU A 1 173 ? -19.226 -0.333  15.084  1.00 7.38  ?  174  LEU A C   1 
ATOM   1331 O  O   . LEU A 1 173 ? -19.261 -0.204  16.315  1.00 8.74  ?  174  LEU A O   1 
ATOM   1332 C  CB  . LEU A 1 173 ? -17.870 -2.408  14.789  1.00 8.45  ?  174  LEU A CB  1 
ATOM   1333 C  CG  . LEU A 1 173 ? -16.556 -1.645  14.542  1.00 6.93  ?  174  LEU A CG  1 
ATOM   1334 C  CD1 . LEU A 1 173 ? -15.371 -2.414  15.142  1.00 8.86  ?  174  LEU A CD1 1 
ATOM   1335 C  CD2 . LEU A 1 173 ? -16.325 -1.201  13.108  1.00 8.63  ?  174  LEU A CD2 1 
ATOM   1336 N  N   . MET A 1 174 ? -19.208 0.715   14.259  1.00 7.10  ?  175  MET A N   1 
ATOM   1337 C  CA  . MET A 1 174 ? -19.270 2.073   14.789  1.00 7.69  ?  175  MET A CA  1 
ATOM   1338 C  C   . MET A 1 174 ? -20.516 2.790   14.307  1.00 8.91  ?  175  MET A C   1 
ATOM   1339 O  O   . MET A 1 174 ? -21.225 3.414   15.109  1.00 8.16  ?  175  MET A O   1 
ATOM   1340 C  CB  . MET A 1 174 ? -18.045 2.900   14.385  1.00 9.27  ?  175  MET A CB  1 
ATOM   1341 C  CG  . MET A 1 174 ? -16.752 2.328   14.899  1.00 10.06 ?  175  MET A CG  1 
ATOM   1342 S  SD  . MET A 1 174 ? -15.351 3.118   14.081  1.00 11.84 ?  175  MET A SD  1 
ATOM   1343 C  CE  . MET A 1 174 ? -14.000 2.306   14.941  1.00 17.55 ?  175  MET A CE  1 
ATOM   1344 N  N   . ALA A 1 175 ? -20.820 2.697   13.007  1.00 7.29  ?  176  ALA A N   1 
ATOM   1345 C  CA  . ALA A 1 175 ? -21.895 3.467   12.399  1.00 6.44  ?  176  ALA A CA  1 
ATOM   1346 C  C   . ALA A 1 175 ? -23.205 2.703   12.307  1.00 6.92  ?  176  ALA A C   1 
ATOM   1347 O  O   . ALA A 1 175 ? -24.152 3.191   11.693  1.00 7.68  ?  176  ALA A O   1 
ATOM   1348 C  CB  . ALA A 1 175 ? -21.461 3.950   11.020  1.00 7.36  ?  176  ALA A CB  1 
ATOM   1349 N  N   . GLY A 1 176 ? -23.281 1.517   12.910  1.00 7.02  ?  177  GLY A N   1 
ATOM   1350 C  CA  . GLY A 1 176 ? -24.511 0.744   12.925  1.00 7.31  ?  177  GLY A CA  1 
ATOM   1351 C  C   . GLY A 1 176 ? -24.657 -0.105  11.683  1.00 7.12  ?  177  GLY A C   1 
ATOM   1352 O  O   . GLY A 1 176 ? -24.664 -1.348  11.753  1.00 7.87  ?  177  GLY A O   1 
ATOM   1353 N  N   . TYR A 1 177 ? -24.786 0.567   10.537  1.00 7.53  ?  178  TYR A N   1 
ATOM   1354 C  CA  . TYR A 1 177 ? -24.777 -0.066  9.225   1.00 7.84  ?  178  TYR A CA  1 
ATOM   1355 C  C   . TYR A 1 177 ? -23.916 0.769   8.294   1.00 7.20  ?  178  TYR A C   1 
ATOM   1356 O  O   . TYR A 1 177 ? -23.874 2.004   8.402   1.00 7.70  ?  178  TYR A O   1 
ATOM   1357 C  CB  . TYR A 1 177 ? -26.190 -0.147  8.606   1.00 8.73  ?  178  TYR A CB  1 
ATOM   1358 C  CG  . TYR A 1 177 ? -27.060 -1.153  9.309   1.00 8.37  ?  178  TYR A CG  1 
ATOM   1359 C  CD1 . TYR A 1 177 ? -26.922 -2.521  9.057   1.00 8.49  ?  178  TYR A CD1 1 
ATOM   1360 C  CD2 . TYR A 1 177 ? -27.977 -0.753  10.274  1.00 8.31  ?  178  TYR A CD2 1 
ATOM   1361 C  CE1 . TYR A 1 177 ? -27.690 -3.461  9.740   1.00 9.34  ?  178  TYR A CE1 1 
ATOM   1362 C  CE2 . TYR A 1 177 ? -28.758 -1.685  10.953  1.00 9.58  ?  178  TYR A CE2 1 
ATOM   1363 C  CZ  . TYR A 1 177 ? -28.607 -3.033  10.673  1.00 10.03 ?  178  TYR A CZ  1 
ATOM   1364 O  OH  . TYR A 1 177 ? -29.360 -3.981  11.335  1.00 11.76 ?  178  TYR A OH  1 
ATOM   1365 N  N   . SER A 1 178 ? -23.225 0.082   7.380   1.00 6.66  ?  179  SER A N   1 
ATOM   1366 C  CA  A SER A 1 178 ? -22.527 0.707   6.270   0.70 6.43  ?  179  SER A CA  1 
ATOM   1367 C  CA  B SER A 1 178 ? -22.530 0.737   6.288   0.30 6.53  ?  179  SER A CA  1 
ATOM   1368 C  C   . SER A 1 178 ? -23.530 1.126   5.202   1.00 7.47  ?  179  SER A C   1 
ATOM   1369 O  O   . SER A 1 178 ? -24.680 0.684   5.190   1.00 7.67  ?  179  SER A O   1 
ATOM   1370 C  CB  A SER A 1 178 ? -21.521 -0.272  5.664   0.70 6.42  ?  179  SER A CB  1 
ATOM   1371 C  CB  B SER A 1 178 ? -21.474 -0.196  5.701   0.30 6.53  ?  179  SER A CB  1 
ATOM   1372 O  OG  A SER A 1 178 ? -20.438 -0.476  6.552   0.70 6.84  ?  179  SER A OG  1 
ATOM   1373 O  OG  B SER A 1 178 ? -22.002 -1.492  5.510   0.30 8.91  ?  179  SER A OG  1 
ATOM   1374 N  N   . GLY A 1 179 ? -23.075 1.966   4.281   1.00 7.12  ?  180  GLY A N   1 
ATOM   1375 C  CA  . GLY A 1 179 ? -23.868 2.373   3.132   1.00 7.31  ?  180  GLY A CA  1 
ATOM   1376 C  C   . GLY A 1 179 ? -24.298 3.832   3.200   1.00 6.45  ?  180  GLY A C   1 
ATOM   1377 O  O   . GLY A 1 179 ? -23.975 4.578   4.127   1.00 7.13  ?  180  GLY A O   1 
ATOM   1378 N  N   . GLY A 1 180 ? -25.061 4.222   2.185   1.00 6.69  ?  181  GLY A N   1 
ATOM   1379 C  CA  . GLY A 1 180 ? -25.607 5.575   2.132   1.00 7.53  ?  181  GLY A CA  1 
ATOM   1380 C  C   . GLY A 1 180 ? -24.554 6.642   2.365   1.00 7.67  ?  181  GLY A C   1 
ATOM   1381 O  O   . GLY A 1 180 ? -23.504 6.671   1.719   1.00 7.54  ?  181  GLY A O   1 
ATOM   1382 N  N   . ARG A 1 181 ? -24.883 7.512   3.322   1.00 6.42  ?  182  ARG A N   1 
ATOM   1383 C  CA  A ARG A 1 181 ? -24.053 8.628   3.772   0.50 7.01  ?  182  ARG A CA  1 
ATOM   1384 C  CA  B ARG A 1 181 ? -24.052 8.627   3.772   0.50 7.01  ?  182  ARG A CA  1 
ATOM   1385 C  C   . ARG A 1 181 ? -22.599 8.279   4.076   1.00 6.59  ?  182  ARG A C   1 
ATOM   1386 O  O   . ARG A 1 181 ? -21.740 9.169   4.017   1.00 6.99  ?  182  ARG A O   1 
ATOM   1387 C  CB  A ARG A 1 181 ? -24.723 9.237   5.012   0.50 8.13  ?  182  ARG A CB  1 
ATOM   1388 C  CB  B ARG A 1 181 ? -24.720 9.241   5.009   0.50 8.13  ?  182  ARG A CB  1 
ATOM   1389 C  CG  A ARG A 1 181 ? -24.394 8.547   6.338   0.50 8.07  ?  182  ARG A CG  1 
ATOM   1390 C  CG  B ARG A 1 181 ? -24.532 8.477   6.334   0.50 7.94  ?  182  ARG A CG  1 
ATOM   1391 C  CD  A ARG A 1 181 ? -24.903 7.108   6.386   0.50 7.29  ?  182  ARG A CD  1 
ATOM   1392 C  CD  B ARG A 1 181 ? -25.222 7.102   6.346   0.50 5.49  ?  182  ARG A CD  1 
ATOM   1393 N  NE  A ARG A 1 181 ? -24.828 6.584   7.743   0.50 7.92  ?  182  ARG A NE  1 
ATOM   1394 N  NE  B ARG A 1 181 ? -25.070 6.472   7.654   0.50 7.03  ?  182  ARG A NE  1 
ATOM   1395 C  CZ  A ARG A 1 181 ? -24.608 5.313   8.054   0.50 6.87  ?  182  ARG A CZ  1 
ATOM   1396 C  CZ  B ARG A 1 181 ? -24.638 5.234   7.882   0.50 6.34  ?  182  ARG A CZ  1 
ATOM   1397 N  NH1 A ARG A 1 181 ? -24.335 4.419   7.115   0.50 6.86  ?  182  ARG A NH1 1 
ATOM   1398 N  NH1 B ARG A 1 181 ? -24.205 4.457   6.897   0.50 6.90  ?  182  ARG A NH1 1 
ATOM   1399 N  NH2 A ARG A 1 181 ? -24.580 4.958   9.330   0.50 6.87  ?  182  ARG A NH2 1 
ATOM   1400 N  NH2 B ARG A 1 181 ? -24.572 4.804   9.135   0.50 7.18  ?  182  ARG A NH2 1 
ATOM   1401 N  N   . LYS A 1 182 ? -22.293 7.023   4.393   1.00 6.52  ?  183  LYS A N   1 
ATOM   1402 C  CA  . LYS A 1 182 ? -20.954 6.683   4.863   1.00 7.33  ?  183  LYS A CA  1 
ATOM   1403 C  C   . LYS A 1 182 ? -19.921 6.750   3.743   1.00 7.02  ?  183  LYS A C   1 
ATOM   1404 O  O   . LYS A 1 182 ? -18.716 6.890   4.025   1.00 7.43  ?  183  LYS A O   1 
ATOM   1405 C  CB  . LYS A 1 182 ? -21.007 5.306   5.532   1.00 7.81  ?  183  LYS A CB  1 
ATOM   1406 C  CG  . LYS A 1 182 ? -19.874 5.000   6.490   1.00 6.89  ?  183  LYS A CG  1 
ATOM   1407 C  CD  . LYS A 1 182 ? -20.195 3.756   7.356   1.00 8.03  ?  183  LYS A CD  1 
ATOM   1408 C  CE  . LYS A 1 182 ? -19.098 3.460   8.368   1.00 8.03  ?  183  LYS A CE  1 
ATOM   1409 N  NZ  . LYS A 1 182 ? -17.844 3.216   7.611   1.00 7.69  ?  183  LYS A NZ  1 
ATOM   1410 N  N   . LEU A 1 183 ? -20.370 6.696   2.484   1.00 7.17  ?  184  LEU A N   1 
ATOM   1411 C  CA  . LEU A 1 183 ? -19.458 6.908   1.365   1.00 6.80  ?  184  LEU A CA  1 
ATOM   1412 C  C   . LEU A 1 183 ? -18.858 8.309   1.397   1.00 7.24  ?  184  LEU A C   1 
ATOM   1413 O  O   . LEU A 1 183 ? -17.744 8.521   0.895   1.00 7.90  ?  184  LEU A O   1 
ATOM   1414 C  CB  . LEU A 1 183 ? -20.190 6.684   0.047   1.00 8.29  ?  184  LEU A CB  1 
ATOM   1415 C  CG  . LEU A 1 183 ? -20.208 5.245   -0.463  1.00 6.42  ?  184  LEU A CG  1 
ATOM   1416 C  CD1 . LEU A 1 183 ? -18.811 4.773   -0.863  1.00 7.55  ?  184  LEU A CD1 1 
ATOM   1417 C  CD2 . LEU A 1 183 ? -20.846 4.267   0.541   1.00 7.43  ?  184  LEU A CD2 1 
ATOM   1418 N  N   . ILE A 1 184 ? -19.591 9.278   1.948   1.00 7.06  ?  185  ILE A N   1 
ATOM   1419 C  CA  A ILE A 1 184 ? -19.099 10.648  2.078   0.55 7.56  ?  185  ILE A CA  1 
ATOM   1420 C  CA  B ILE A 1 184 ? -19.105 10.647  2.082   0.45 7.56  ?  185  ILE A CA  1 
ATOM   1421 C  C   . ILE A 1 184 ? -18.324 10.808  3.379   1.00 8.00  ?  185  ILE A C   1 
ATOM   1422 O  O   . ILE A 1 184 ? -17.159 11.220  3.371   1.00 7.75  ?  185  ILE A O   1 
ATOM   1423 C  CB  A ILE A 1 184 ? -20.239 11.674  1.983   0.55 6.74  ?  185  ILE A CB  1 
ATOM   1424 C  CB  B ILE A 1 184 ? -20.260 11.657  1.985   0.45 6.75  ?  185  ILE A CB  1 
ATOM   1425 C  CG1 A ILE A 1 184 ? -20.963 11.511  0.656   0.55 8.65  ?  185  ILE A CG1 1 
ATOM   1426 C  CG1 B ILE A 1 184 ? -20.811 11.668  0.553   0.45 8.27  ?  185  ILE A CG1 1 
ATOM   1427 C  CG2 A ILE A 1 184 ? -19.678 13.104  2.071   0.55 8.81  ?  185  ILE A CG2 1 
ATOM   1428 C  CG2 B ILE A 1 184 ? -19.775 13.040  2.425   0.45 8.78  ?  185  ILE A CG2 1 
ATOM   1429 C  CD1 A ILE A 1 184 ? -22.236 12.268  0.604   0.55 9.57  ?  185  ILE A CD1 1 
ATOM   1430 C  CD1 B ILE A 1 184 ? -22.077 10.832  0.367   0.45 9.60  ?  185  ILE A CD1 1 
ATOM   1431 N  N   . CYS A 1 185 ? -18.955 10.488  4.504   1.00 7.11  ?  186  CYS A N   1 
ATOM   1432 C  CA  . CYS A 1 185 ? -18.282 10.570  5.800   1.00 7.73  ?  186  CYS A CA  1 
ATOM   1433 C  C   . CYS A 1 185 ? -18.238 9.174   6.401   1.00 7.48  ?  186  CYS A C   1 
ATOM   1434 O  O   . CYS A 1 185 ? -19.272 8.683   6.890   1.00 7.55  ?  186  CYS A O   1 
ATOM   1435 C  CB  . CYS A 1 185 ? -19.012 11.531  6.738   1.00 8.24  ?  186  CYS A CB  1 
ATOM   1436 S  SG  . CYS A 1 185 ? -18.182 11.740  8.328   1.00 9.94  ?  186  CYS A SG  1 
ATOM   1437 N  N   . PRO A 1 186 ? -17.077 8.509   6.438   1.00 7.00  ?  187  PRO A N   1 
ATOM   1438 C  CA  . PRO A 1 186 ? -15.745 9.079   6.209   1.00 7.44  ?  187  PRO A CA  1 
ATOM   1439 C  C   . PRO A 1 186 ? -15.152 8.775   4.843   1.00 6.83  ?  187  PRO A C   1 
ATOM   1440 O  O   . PRO A 1 186 ? -13.993 9.122   4.620   1.00 7.45  ?  187  PRO A O   1 
ATOM   1441 C  CB  . PRO A 1 186 ? -14.911 8.334   7.240   1.00 7.16  ?  187  PRO A CB  1 
ATOM   1442 C  CG  . PRO A 1 186 ? -15.480 6.939   7.149   1.00 8.47  ?  187  PRO A CG  1 
ATOM   1443 C  CD  . PRO A 1 186 ? -16.979 7.109   6.897   1.00 7.26  ?  187  PRO A CD  1 
ATOM   1444 N  N   . GLY A 1 187 ? -15.917 8.142   3.945   1.00 7.07  ?  188  GLY A N   1 
ATOM   1445 C  CA  . GLY A 1 187 ? -15.334 7.617   2.717   1.00 7.07  ?  188  GLY A CA  1 
ATOM   1446 C  C   . GLY A 1 187 ? -14.458 8.606   1.961   1.00 6.67  ?  188  GLY A C   1 
ATOM   1447 O  O   . GLY A 1 187 ? -13.422 8.227   1.402   1.00 7.38  ?  188  GLY A O   1 
ATOM   1448 N  N   . ILE A 1 188 ? -14.867 9.878   1.907   1.00 6.81  ?  189  ILE A N   1 
ATOM   1449 C  CA  . ILE A 1 188 ? -14.053 10.890  1.229   1.00 7.13  ?  189  ILE A CA  1 
ATOM   1450 C  C   . ILE A 1 188 ? -13.790 12.088  2.144   1.00 7.81  ?  189  ILE A C   1 
ATOM   1451 O  O   . ILE A 1 188 ? -13.626 13.227  1.676   1.00 7.53  ?  189  ILE A O   1 
ATOM   1452 C  CB  . ILE A 1 188 ? -14.647 11.310  -0.133  1.00 6.84  ?  189  ILE A CB  1 
ATOM   1453 C  CG1 . ILE A 1 188 ? -16.103 11.748  0.019   1.00 7.57  ?  189  ILE A CG1 1 
ATOM   1454 C  CG2 . ILE A 1 188 ? -14.539 10.174  -1.134  1.00 8.45  ?  189  ILE A CG2 1 
ATOM   1455 C  CD1 . ILE A 1 188 ? -16.611 12.538  -1.159  1.00 8.37  ?  189  ILE A CD1 1 
ATOM   1456 N  N   . ALA A 1 189 ? -13.694 11.836  3.444   1.00 6.79  ?  190  ALA A N   1 
ATOM   1457 C  CA  . ALA A 1 189 ? -13.437 12.878  4.425   1.00 7.64  ?  190  ALA A CA  1 
ATOM   1458 C  C   . ALA A 1 189 ? -11.983 12.862  4.890   1.00 7.13  ?  190  ALA A C   1 
ATOM   1459 O  O   . ALA A 1 189 ? -11.333 11.813  4.942   1.00 8.31  ?  190  ALA A O   1 
ATOM   1460 C  CB  . ALA A 1 189 ? -14.355 12.688  5.625   1.00 8.59  ?  190  ALA A CB  1 
ATOM   1461 N  N   . ALA A 1 190 ? -11.482 14.045  5.243   1.00 7.40  ?  191  ALA A N   1 
ATOM   1462 C  CA  . ALA A 1 190 ? -10.100 14.156  5.679   1.00 7.65  ?  191  ALA A CA  1 
ATOM   1463 C  C   . ALA A 1 190 ? -9.938  13.677  7.121   1.00 7.93  ?  191  ALA A C   1 
ATOM   1464 O  O   . ALA A 1 190 ? -10.890 13.647  7.911   1.00 7.98  ?  191  ALA A O   1 
ATOM   1465 C  CB  . ALA A 1 190 ? -9.636  15.612  5.599   1.00 9.08  ?  191  ALA A CB  1 
ATOM   1466 N  N   . PHE A 1 191 ? -8.688  13.347  7.471   1.00 8.93  ?  192  PHE A N   1 
ATOM   1467 C  CA  . PHE A 1 191 ? -8.348  13.032  8.854   1.00 9.17  ?  192  PHE A CA  1 
ATOM   1468 C  C   . PHE A 1 191 ? -8.762  14.144  9.811   1.00 8.84  ?  192  PHE A C   1 
ATOM   1469 O  O   . PHE A 1 191 ? -9.179  13.874  10.942  1.00 8.95  ?  192  PHE A O   1 
ATOM   1470 C  CB  . PHE A 1 191 ? -6.851  12.732  8.949   1.00 10.86 ?  192  PHE A CB  1 
ATOM   1471 C  CG  . PHE A 1 191 ? -6.418  12.243  10.299  1.00 9.77  ?  192  PHE A CG  1 
ATOM   1472 C  CD1 . PHE A 1 191 ? -6.887  11.040  10.806  1.00 10.76 ?  192  PHE A CD1 1 
ATOM   1473 C  CD2 . PHE A 1 191 ? -5.527  12.977  11.054  1.00 13.41 ?  192  PHE A CD2 1 
ATOM   1474 C  CE1 . PHE A 1 191 ? -6.480  10.586  12.052  1.00 11.20 ?  192  PHE A CE1 1 
ATOM   1475 C  CE2 . PHE A 1 191 ? -5.116  12.531  12.299  1.00 14.43 ?  192  PHE A CE2 1 
ATOM   1476 C  CZ  . PHE A 1 191 ? -5.591  11.330  12.793  1.00 12.95 ?  192  PHE A CZ  1 
ATOM   1477 N  N   . GLU A 1 192 ? -8.696  15.399  9.366   1.00 8.80  ?  193  GLU A N   1 
ATOM   1478 C  CA  . GLU A 1 192 ? -9.134  16.513  10.198  1.00 9.63  ?  193  GLU A CA  1 
ATOM   1479 C  C   . GLU A 1 192 ? -10.571 16.345  10.669  1.00 10.03 ?  193  GLU A C   1 
ATOM   1480 O  O   . GLU A 1 192 ? -10.923 16.801  11.764  1.00 12.06 ?  193  GLU A O   1 
ATOM   1481 C  CB  . GLU A 1 192 ? -8.995  17.816  9.418   1.00 11.97 ?  193  GLU A CB  1 
ATOM   1482 C  CG  . GLU A 1 192 ? -7.588  18.344  9.390   1.00 23.93 ?  193  GLU A CG  1 
ATOM   1483 C  CD  . GLU A 1 192 ? -7.252  19.115  10.655  1.00 23.97 ?  193  GLU A CD  1 
ATOM   1484 O  OE1 . GLU A 1 192 ? -8.011  20.039  11.031  1.00 27.66 ?  193  GLU A OE1 1 
ATOM   1485 O  OE2 . GLU A 1 192 ? -6.232  18.771  11.286  1.00 40.33 -1 193  GLU A OE2 1 
ATOM   1486 N  N   . THR A 1 193 ? -11.424 15.744  9.841   1.00 9.71  ?  194  THR A N   1 
ATOM   1487 C  CA  . THR A 1 193 ? -12.790 15.393  10.209  1.00 8.85  ?  194  THR A CA  1 
ATOM   1488 C  C   . THR A 1 193 ? -12.835 14.059  10.948  1.00 8.66  ?  194  THR A C   1 
ATOM   1489 O  O   . THR A 1 193 ? -13.412 13.960  12.036  1.00 9.46  ?  194  THR A O   1 
ATOM   1490 C  CB  . THR A 1 193 ? -13.622 15.283  8.926   1.00 8.20  ?  194  THR A CB  1 
ATOM   1491 O  OG1 . THR A 1 193 ? -13.649 16.553  8.265   1.00 8.64  ?  194  THR A OG1 1 
ATOM   1492 C  CG2 . THR A 1 193 ? -15.046 14.838  9.219   1.00 9.68  ?  194  THR A CG2 1 
ATOM   1493 N  N   . VAL A 1 194 ? -12.206 13.034  10.371  1.00 8.76  ?  195  VAL A N   1 
ATOM   1494 C  CA  . VAL A 1 194 ? -12.359 11.667  10.861  1.00 10.18 ?  195  VAL A CA  1 
ATOM   1495 C  C   . VAL A 1 194 ? -11.757 11.478  12.250  1.00 9.61  ?  195  VAL A C   1 
ATOM   1496 O  O   . VAL A 1 194 ? -12.288 10.704  13.053  1.00 9.81  ?  195  VAL A O   1 
ATOM   1497 C  CB  . VAL A 1 194 ? -11.823 10.659  9.825   1.00 7.85  ?  195  VAL A CB  1 
ATOM   1498 C  CG1 . VAL A 1 194 ? -11.921 9.216   10.348  1.00 9.40  ?  195  VAL A CG1 1 
ATOM   1499 C  CG2 . VAL A 1 194 ? -12.626 10.779  8.542   1.00 10.34 ?  195  VAL A CG2 1 
ATOM   1500 N  N   . LYS A 1 195 ? -10.657 12.168  12.567  1.00 8.69  ?  196  LYS A N   1 
ATOM   1501 C  CA  . LYS A 1 195 ? -10.046 11.960  13.875  1.00 8.91  ?  196  LYS A CA  1 
ATOM   1502 C  C   . LYS A 1 195 ? -10.995 12.356  14.997  1.00 11.32 ?  196  LYS A C   1 
ATOM   1503 O  O   . LYS A 1 195 ? -10.990 11.727  16.060  1.00 10.98 ?  196  LYS A O   1 
ATOM   1504 C  CB  . LYS A 1 195 ? -8.716  12.715  13.986  1.00 10.96 ?  196  LYS A CB  1 
ATOM   1505 C  CG  . LYS A 1 195 ? -8.861  14.221  14.207  1.00 11.50 ?  196  LYS A CG  1 
ATOM   1506 C  CD  . LYS A 1 195 ? -7.534  14.935  14.074  1.00 14.22 ?  196  LYS A CD  1 
ATOM   1507 C  CE  . LYS A 1 195 ? -7.693  16.402  14.476  1.00 18.32 ?  196  LYS A CE  1 
ATOM   1508 N  NZ  . LYS A 1 195 ? -6.410  17.157  14.372  1.00 23.68 ?  196  LYS A NZ  1 
ATOM   1509 N  N   . LEU A 1 196 ? -11.835 13.371  14.774  1.00 9.35  ?  197  LEU A N   1 
ATOM   1510 C  CA  . LEU A 1 196 ? -12.825 13.769  15.771  1.00 10.33 ?  197  LEU A CA  1 
ATOM   1511 C  C   . LEU A 1 196 ? -14.044 12.860  15.742  1.00 9.71  ?  197  LEU A C   1 
ATOM   1512 O  O   . LEU A 1 196 ? -14.533 12.437  16.796  1.00 11.62 ?  197  LEU A O   1 
ATOM   1513 C  CB  . LEU A 1 196 ? -13.240 15.217  15.529  1.00 10.73 ?  197  LEU A CB  1 
ATOM   1514 C  CG  . LEU A 1 196 ? -12.108 16.227  15.718  1.00 12.49 ?  197  LEU A CG  1 
ATOM   1515 C  CD1 . LEU A 1 196 ? -12.633 17.633  15.516  1.00 15.99 ?  197  LEU A CD1 1 
ATOM   1516 C  CD2 . LEU A 1 196 ? -11.512 16.108  17.106  1.00 17.90 ?  197  LEU A CD2 1 
ATOM   1517 N  N   . TRP A 1 197 ? -14.529 12.534  14.547  1.00 10.13 ?  198  TRP A N   1 
ATOM   1518 C  CA  . TRP A 1 197 ? -15.735 11.724  14.428  1.00 9.46  ?  198  TRP A CA  1 
ATOM   1519 C  C   . TRP A 1 197 ? -15.508 10.295  14.927  1.00 10.81 ?  198  TRP A C   1 
ATOM   1520 O  O   . TRP A 1 197 ? -16.413 9.691   15.513  1.00 12.14 ?  198  TRP A O   1 
ATOM   1521 C  CB  . TRP A 1 197 ? -16.202 11.761  12.974  1.00 8.40  ?  198  TRP A CB  1 
ATOM   1522 C  CG  . TRP A 1 197 ? -17.369 10.864  12.691  1.00 9.07  ?  198  TRP A CG  1 
ATOM   1523 C  CD1 . TRP A 1 197 ? -18.640 10.982  13.185  1.00 9.72  ?  198  TRP A CD1 1 
ATOM   1524 C  CD2 . TRP A 1 197 ? -17.375 9.730   11.822  1.00 8.28  ?  198  TRP A CD2 1 
ATOM   1525 N  NE1 . TRP A 1 197 ? -19.429 9.966   12.693  1.00 9.63  ?  198  TRP A NE1 1 
ATOM   1526 C  CE2 . TRP A 1 197 ? -18.677 9.197   11.841  1.00 8.89  ?  198  TRP A CE2 1 
ATOM   1527 C  CE3 . TRP A 1 197 ? -16.399 9.107   11.038  1.00 8.86  ?  198  TRP A CE3 1 
ATOM   1528 C  CZ2 . TRP A 1 197 ? -19.028 8.060   11.117  1.00 8.70  ?  198  TRP A CZ2 1 
ATOM   1529 C  CZ3 . TRP A 1 197 ? -16.751 7.989   10.305  1.00 10.77 ?  198  TRP A CZ3 1 
ATOM   1530 C  CH2 . TRP A 1 197 ? -18.056 7.480   10.344  1.00 10.73 ?  198  TRP A CH2 1 
ATOM   1531 N  N   . HIS A 1 198 ? -14.311 9.742   14.692  1.00 8.76  ?  199  HIS A N   1 
ATOM   1532 C  CA  A HIS A 1 198 ? -13.880 8.459   15.234  0.50 8.73  ?  199  HIS A CA  1 
ATOM   1533 C  CA  B HIS A 1 198 ? -13.886 8.458   15.235  0.50 8.73  ?  199  HIS A CA  1 
ATOM   1534 C  C   . HIS A 1 198 ? -13.160 8.603   16.573  1.00 10.31 ?  199  HIS A C   1 
ATOM   1535 O  O   . HIS A 1 198 ? -12.388 7.714   16.953  1.00 12.14 ?  199  HIS A O   1 
ATOM   1536 C  CB  A HIS A 1 198 ? -12.963 7.738   14.234  0.50 9.39  ?  199  HIS A CB  1 
ATOM   1537 C  CB  B HIS A 1 198 ? -12.986 7.736   14.222  0.50 9.41  ?  199  HIS A CB  1 
ATOM   1538 C  CG  A HIS A 1 198 ? -13.678 6.920   13.194  0.50 9.63  ?  199  HIS A CG  1 
ATOM   1539 C  CG  B HIS A 1 198 ? -13.717 6.849   13.254  0.50 9.70  ?  199  HIS A CG  1 
ATOM   1540 N  ND1 A HIS A 1 198 ? -15.000 6.543   13.303  0.50 10.46 ?  199  HIS A ND1 1 
ATOM   1541 N  ND1 B HIS A 1 198 ? -15.090 6.727   13.226  0.50 10.63 ?  199  HIS A ND1 1 
ATOM   1542 C  CD2 A HIS A 1 198 ? -13.243 6.423   12.010  0.50 7.83  ?  199  HIS A CD2 1 
ATOM   1543 C  CD2 B HIS A 1 198 ? -13.253 6.093   12.228  0.50 9.84  ?  199  HIS A CD2 1 
ATOM   1544 C  CE1 A HIS A 1 198 ? -15.340 5.830   12.243  0.50 12.38 ?  199  HIS A CE1 1 
ATOM   1545 C  CE1 B HIS A 1 198 ? -15.435 5.890   12.262  0.50 12.39 ?  199  HIS A CE1 1 
ATOM   1546 N  NE2 A HIS A 1 198 ? -14.292 5.741   11.442  0.50 8.67  ?  199  HIS A NE2 1 
ATOM   1547 N  NE2 B HIS A 1 198 ? -14.340 5.500   11.632  0.50 9.23  ?  199  HIS A NE2 1 
ATOM   1548 N  N   . GLY A 1 199 ? -13.375 9.705   17.289  1.00 11.16 ?  200  GLY A N   1 
ATOM   1549 C  CA  . GLY A 1 199 ? -12.763 9.892   18.586  1.00 10.62 ?  200  GLY A CA  1 
ATOM   1550 C  C   . GLY A 1 199 ? -13.579 9.231   19.669  1.00 11.44 ?  200  GLY A C   1 
ATOM   1551 O  O   . GLY A 1 199 ? -14.734 8.830   19.470  1.00 9.59  ?  200  GLY A O   1 
ATOM   1552 N  N   . PRO A 1 200 ? -12.981 9.107   20.858  1.00 9.98  ?  201  PRO A N   1 
ATOM   1553 C  CA  . PRO A 1 200 ? -13.687 8.459   21.972  1.00 10.85 ?  201  PRO A CA  1 
ATOM   1554 C  C   . PRO A 1 200 ? -14.973 9.154   22.387  1.00 10.14 ?  201  PRO A C   1 
ATOM   1555 O  O   . PRO A 1 200 ? -15.874 8.490   22.911  1.00 11.72 ?  201  PRO A O   1 
ATOM   1556 C  CB  . PRO A 1 200 ? -12.634 8.445   23.093  1.00 12.10 ?  201  PRO A CB  1 
ATOM   1557 C  CG  . PRO A 1 200 ? -11.710 9.556   22.737  1.00 15.68 ?  201  PRO A CG  1 
ATOM   1558 C  CD  . PRO A 1 200 ? -11.599 9.448   21.237  1.00 12.32 ?  201  PRO A CD  1 
ATOM   1559 N  N   . ARG A 1 201 ? -15.114 10.458  22.138  1.00 10.74 ?  202  ARG A N   1 
ATOM   1560 C  CA  . ARG A 1 201 ? -16.366 11.123  22.474  1.00 12.26 ?  202  ARG A CA  1 
ATOM   1561 C  C   . ARG A 1 201 ? -17.536 10.568  21.673  1.00 14.60 ?  202  ARG A C   1 
ATOM   1562 O  O   . ARG A 1 201 ? -18.688 10.731  22.085  1.00 14.12 ?  202  ARG A O   1 
ATOM   1563 C  CB  . ARG A 1 201 ? -16.214 12.635  22.290  1.00 14.43 ?  202  ARG A CB  1 
ATOM   1564 C  CG  . ARG A 1 201 ? -15.548 13.301  23.501  1.00 23.09 ?  202  ARG A CG  1 
ATOM   1565 C  CD  . ARG A 1 201 ? -15.749 14.810  23.517  1.00 35.19 ?  202  ARG A CD  1 
ATOM   1566 N  NE  . ARG A 1 201 ? -15.045 15.447  22.406  1.00 39.76 ?  202  ARG A NE  1 
ATOM   1567 C  CZ  . ARG A 1 201 ? -13.723 15.561  22.316  1.00 41.38 ?  202  ARG A CZ  1 
ATOM   1568 N  NH1 . ARG A 1 201 ? -12.937 15.089  23.278  1.00 44.88 ?  202  ARG A NH1 1 
ATOM   1569 N  NH2 . ARG A 1 201 ? -13.182 16.152  21.258  1.00 44.97 ?  202  ARG A NH2 1 
ATOM   1570 N  N   . PHE A 1 202 ? -17.266 9.908   20.548  1.00 10.45 ?  203  PHE A N   1 
ATOM   1571 C  CA  . PHE A 1 202 ? -18.277 9.144   19.832  1.00 10.39 ?  203  PHE A CA  1 
ATOM   1572 C  C   . PHE A 1 202 ? -18.241 7.660   20.176  1.00 10.03 ?  203  PHE A C   1 
ATOM   1573 O  O   . PHE A 1 202 ? -19.283 7.064   20.460  1.00 11.61 ?  203  PHE A O   1 
ATOM   1574 C  CB  . PHE A 1 202 ? -18.108 9.315   18.317  1.00 10.38 ?  203  PHE A CB  1 
ATOM   1575 C  CG  . PHE A 1 202 ? -18.536 10.655  17.816  1.00 8.46  ?  203  PHE A CG  1 
ATOM   1576 C  CD1 . PHE A 1 202 ? -17.653 11.729  17.786  1.00 9.62  ?  203  PHE A CD1 1 
ATOM   1577 C  CD2 . PHE A 1 202 ? -19.836 10.839  17.378  1.00 9.29  ?  203  PHE A CD2 1 
ATOM   1578 C  CE1 . PHE A 1 202 ? -18.075 12.967  17.337  1.00 10.56 ?  203  PHE A CE1 1 
ATOM   1579 C  CE2 . PHE A 1 202 ? -20.263 12.077  16.933  1.00 9.39  ?  203  PHE A CE2 1 
ATOM   1580 C  CZ  . PHE A 1 202 ? -19.379 13.138  16.909  1.00 8.99  ?  203  PHE A CZ  1 
ATOM   1581 N  N   . LEU A 1 203 ? -17.058 7.048   20.149  1.00 8.89  ?  204  LEU A N   1 
ATOM   1582 C  CA  . LEU A 1 203 ? -16.979 5.592   20.156  1.00 11.42 ?  204  LEU A CA  1 
ATOM   1583 C  C   . LEU A 1 203 ? -17.193 4.977   21.533  1.00 10.74 ?  204  LEU A C   1 
ATOM   1584 O  O   . LEU A 1 203 ? -17.481 3.781   21.609  1.00 11.96 ?  204  LEU A O   1 
ATOM   1585 C  CB  . LEU A 1 203 ? -15.635 5.160   19.582  1.00 10.00 ?  204  LEU A CB  1 
ATOM   1586 C  CG  . LEU A 1 203 ? -15.430 5.566   18.120  1.00 10.08 ?  204  LEU A CG  1 
ATOM   1587 C  CD1 . LEU A 1 203 ? -14.183 4.897   17.573  1.00 11.97 ?  204  LEU A CD1 1 
ATOM   1588 C  CD2 . LEU A 1 203 ? -16.641 5.171   17.282  1.00 11.50 ?  204  LEU A CD2 1 
ATOM   1589 N  N   . GLU A 1 204 ? -17.083 5.752   22.611  1.00 10.52 ?  205  GLU A N   1 
ATOM   1590 C  CA  . GLU A 1 204 ? -17.264 5.176   23.937  1.00 10.37 ?  205  GLU A CA  1 
ATOM   1591 C  C   . GLU A 1 204 ? -18.733 5.040   24.315  1.00 15.83 ?  205  GLU A C   1 
ATOM   1592 O  O   . GLU A 1 204 ? -19.035 4.494   25.377  1.00 19.56 ?  205  GLU A O   1 
ATOM   1593 C  CB  . GLU A 1 204 ? -16.525 6.024   24.976  1.00 11.58 ?  205  GLU A CB  1 
ATOM   1594 C  CG  . GLU A 1 204 ? -15.000 5.894   24.882  1.00 12.14 ?  205  GLU A CG  1 
ATOM   1595 C  CD  . GLU A 1 204 ? -14.512 4.479   25.140  1.00 13.57 ?  205  GLU A CD  1 
ATOM   1596 O  OE1 . GLU A 1 204 ? -14.564 4.061   26.310  1.00 16.80 ?  205  GLU A OE1 1 
ATOM   1597 O  OE2 . GLU A 1 204 ? -14.042 3.792   24.191  1.00 12.70 -1 205  GLU A OE2 1 
ATOM   1598 N  N   . HIS A 1 205 ? -19.644 5.476   23.471  1.00 15.39 ?  206  HIS A N   1 
ATOM   1599 C  CA  . HIS A 1 205 ? -21.055 5.391   23.824  1.00 15.26 ?  206  HIS A CA  1 
ATOM   1600 C  C   . HIS A 1 205 ? -21.613 4.013   23.471  1.00 14.22 ?  206  HIS A C   1 
ATOM   1601 O  O   . HIS A 1 205 ? -21.216 3.424   22.464  1.00 13.25 ?  206  HIS A O   1 
ATOM   1602 C  CB  . HIS A 1 205 ? -21.819 6.471   23.084  1.00 17.11 ?  206  HIS A CB  1 
ATOM   1603 C  CG  . HIS A 1 205 ? -21.546 7.832   23.630  1.00 16.10 ?  206  HIS A CG  1 
ATOM   1604 N  ND1 . HIS A 1 205 ? -22.175 8.327   24.753  1.00 24.38 ?  206  HIS A ND1 1 
ATOM   1605 C  CD2 . HIS A 1 205 ? -20.658 8.779   23.248  1.00 19.49 ?  206  HIS A CD2 1 
ATOM   1606 C  CE1 . HIS A 1 205 ? -21.712 9.537   25.016  1.00 27.88 ?  206  HIS A CE1 1 
ATOM   1607 N  NE2 . HIS A 1 205 ? -20.787 9.832   24.119  1.00 21.61 ?  206  HIS A NE2 1 
ATOM   1608 N  N   . PRO A 1 206 ? -22.542 3.483   24.271  1.00 12.85 ?  207  PRO A N   1 
ATOM   1609 C  CA  . PRO A 1 206 ? -22.976 2.092   24.062  1.00 14.08 ?  207  PRO A CA  1 
ATOM   1610 C  C   . PRO A 1 206 ? -23.640 1.829   22.721  1.00 12.27 ?  207  PRO A C   1 
ATOM   1611 O  O   . PRO A 1 206 ? -23.526 0.710   22.210  1.00 15.07 ?  207  PRO A O   1 
ATOM   1612 C  CB  . PRO A 1 206 ? -23.933 1.828   25.235  1.00 15.87 ?  207  PRO A CB  1 
ATOM   1613 C  CG  . PRO A 1 206 ? -24.341 3.184   25.711  1.00 21.13 ?  207  PRO A CG  1 
ATOM   1614 C  CD  . PRO A 1 206 ? -23.170 4.085   25.461  1.00 15.35 ?  207  PRO A CD  1 
ATOM   1615 N  N   . LEU A 1 207 ? -24.328 2.804   22.135  1.00 10.72 ?  208  LEU A N   1 
ATOM   1616 C  CA  . LEU A 1 207 ? -25.033 2.583   20.877  1.00 10.60 ?  208  LEU A CA  1 
ATOM   1617 C  C   . LEU A 1 207 ? -24.188 2.911   19.657  1.00 9.00  ?  208  LEU A C   1 
ATOM   1618 O  O   . LEU A 1 207 ? -24.698 2.841   18.538  1.00 10.43 ?  208  LEU A O   1 
ATOM   1619 C  CB  . LEU A 1 207 ? -26.361 3.349   20.854  1.00 11.13 ?  208  LEU A CB  1 
ATOM   1620 C  CG  . LEU A 1 207 ? -27.351 2.880   21.937  1.00 13.72 ?  208  LEU A CG  1 
ATOM   1621 C  CD1 . LEU A 1 207 ? -28.735 3.506   21.747  1.00 15.95 ?  208  LEU A CD1 1 
ATOM   1622 C  CD2 . LEU A 1 207 ? -27.456 1.340   21.973  1.00 14.20 ?  208  LEU A CD2 1 
ATOM   1623 N  N   . ALA A 1 208 ? -22.913 3.243   19.846  1.00 8.60  ?  209  ALA A N   1 
ATOM   1624 C  CA  . ALA A 1 208 ? -21.955 3.288   18.743  1.00 8.48  ?  209  ALA A CA  1 
ATOM   1625 C  C   . ALA A 1 208 ? -21.546 1.840   18.503  1.00 8.93  ?  209  ALA A C   1 
ATOM   1626 O  O   . ALA A 1 208 ? -20.508 1.361   18.974  1.00 9.97  ?  209  ALA A O   1 
ATOM   1627 C  CB  . ALA A 1 208 ? -20.766 4.174   19.089  1.00 9.46  ?  209  ALA A CB  1 
ATOM   1628 N  N   . ASP A 1 209 ? -22.406 1.125   17.779  1.00 7.81  ?  210  ASP A N   1 
ATOM   1629 C  CA  . ASP A 1 209 ? -22.318 -0.330  17.763  1.00 9.17  ?  210  ASP A CA  1 
ATOM   1630 C  C   . ASP A 1 209 ? -23.149 -0.877  16.615  1.00 8.62  ?  210  ASP A C   1 
ATOM   1631 O  O   . ASP A 1 209 ? -24.020 -0.189  16.067  1.00 8.32  ?  210  ASP A O   1 
ATOM   1632 C  CB  . ASP A 1 209 ? -22.808 -0.895  19.106  1.00 10.96 ?  210  ASP A CB  1 
ATOM   1633 C  CG  . ASP A 1 209 ? -22.475 -2.362  19.315  1.00 18.47 ?  210  ASP A CG  1 
ATOM   1634 O  OD1 . ASP A 1 209 ? -21.544 -2.900  18.682  1.00 14.74 ?  210  ASP A OD1 1 
ATOM   1635 O  OD2 . ASP A 1 209 ? -23.181 -2.978  20.147  1.00 19.22 -1 210  ASP A OD2 1 
ATOM   1636 N  N   . CYS A 1 210 ? -22.890 -2.149  16.301  1.00 9.98  ?  211  CYS A N   1 
ATOM   1637 C  CA  A CYS A 1 210 ? -23.537 -2.831  15.184  0.70 10.29 ?  211  CYS A CA  1 
ATOM   1638 C  CA  B CYS A 1 210 ? -23.543 -2.797  15.174  0.30 10.26 ?  211  CYS A CA  1 
ATOM   1639 C  C   . CYS A 1 210 ? -25.057 -2.773  15.307  1.00 10.99 ?  211  CYS A C   1 
ATOM   1640 O  O   . CYS A 1 210 ? -25.618 -3.052  16.371  1.00 10.55 ?  211  CYS A O   1 
ATOM   1641 C  CB  A CYS A 1 210 ? -23.094 -4.305  15.161  0.70 10.79 ?  211  CYS A CB  1 
ATOM   1642 C  CB  B CYS A 1 210 ? -23.068 -4.239  15.078  0.30 10.97 ?  211  CYS A CB  1 
ATOM   1643 S  SG  A CYS A 1 210 ? -21.302 -4.667  15.392  0.70 9.40  ?  211  CYS A SG  1 
ATOM   1644 S  SG  B CYS A 1 210 ? -21.607 -4.338  14.090  0.30 13.10 ?  211  CYS A SG  1 
ATOM   1645 N  N   . GLY A 1 211 ? -25.722 -2.430  14.210  1.00 9.44  ?  212  GLY A N   1 
ATOM   1646 C  CA  . GLY A 1 211 ? -27.161 -2.479  14.118  1.00 10.41 ?  212  GLY A CA  1 
ATOM   1647 C  C   . GLY A 1 211 ? -27.908 -1.271  14.637  1.00 10.77 ?  212  GLY A C   1 
ATOM   1648 O  O   . GLY A 1 211 ? -29.136 -1.220  14.489  1.00 14.12 ?  212  GLY A O   1 
ATOM   1649 N  N   . PHE A 1 212 ? -27.230 -0.290  15.234  1.00 8.97  ?  213  PHE A N   1 
ATOM   1650 C  CA  . PHE A 1 212 ? -27.915 0.878   15.780  1.00 11.22 ?  213  PHE A CA  1 
ATOM   1651 C  C   . PHE A 1 212 ? -27.716 2.085   14.868  1.00 9.91  ?  213  PHE A C   1 
ATOM   1652 O  O   . PHE A 1 212 ? -26.581 2.522   14.640  1.00 9.28  ?  213  PHE A O   1 
ATOM   1653 C  CB  . PHE A 1 212 ? -27.407 1.212   17.183  1.00 10.29 ?  213  PHE A CB  1 
ATOM   1654 C  CG  . PHE A 1 212 ? -27.670 0.137   18.190  1.00 11.56 ?  213  PHE A CG  1 
ATOM   1655 C  CD1 . PHE A 1 212 ? -28.951 -0.107  18.653  1.00 15.34 ?  213  PHE A CD1 1 
ATOM   1656 C  CD2 . PHE A 1 212 ? -26.634 -0.668  18.640  1.00 14.01 ?  213  PHE A CD2 1 
ATOM   1657 C  CE1 . PHE A 1 212 ? -29.189 -1.133  19.577  1.00 16.62 ?  213  PHE A CE1 1 
ATOM   1658 C  CE2 . PHE A 1 212 ? -26.864 -1.683  19.557  1.00 15.13 ?  213  PHE A CE2 1 
ATOM   1659 C  CZ  . PHE A 1 212 ? -28.146 -1.915  20.019  1.00 16.37 ?  213  PHE A CZ  1 
ATOM   1660 N  N   . LEU A 1 213 ? -28.818 2.608   14.335  1.00 12.24 ?  214  LEU A N   1 
ATOM   1661 C  CA  . LEU A 1 213 ? -28.853 3.930   13.720  1.00 10.62 ?  214  LEU A CA  1 
ATOM   1662 C  C   . LEU A 1 213 ? -29.509 4.908   14.680  1.00 13.47 ?  214  LEU A C   1 
ATOM   1663 O  O   . LEU A 1 213 ? -28.897 5.903   15.078  1.00 12.52 ?  214  LEU A O   1 
ATOM   1664 C  CB  . LEU A 1 213 ? -29.666 3.876   12.425  1.00 10.13 ?  214  LEU A CB  1 
ATOM   1665 C  CG  . LEU A 1 213 ? -29.074 2.995   11.318  1.00 10.72 ?  214  LEU A CG  1 
ATOM   1666 C  CD1 . LEU A 1 213 ? -29.899 3.128   10.053  1.00 12.12 ?  214  LEU A CD1 1 
ATOM   1667 C  CD2 . LEU A 1 213 ? -27.601 3.317   11.048  1.00 9.03  ?  214  LEU A CD2 1 
ATOM   1668 N  N   . GLU A 1 214 ? -30.744 4.603   15.081  1.00 15.21 ?  215  GLU A N   1 
ATOM   1669 C  CA  . GLU A 1 214 ? -31.421 5.354   16.124  1.00 16.05 ?  215  GLU A CA  1 
ATOM   1670 C  C   . GLU A 1 214 ? -30.615 5.268   17.407  1.00 13.80 ?  215  GLU A C   1 
ATOM   1671 O  O   . GLU A 1 214 ? -30.220 4.178   17.840  1.00 16.64 ?  215  GLU A O   1 
ATOM   1672 C  CB  . GLU A 1 214 ? -32.806 4.750   16.349  1.00 22.87 ?  215  GLU A CB  1 
ATOM   1673 C  CG  . GLU A 1 214 ? -33.660 4.755   15.096  1.00 29.08 ?  215  GLU A CG  1 
ATOM   1674 C  CD  . GLU A 1 214 ? -34.345 6.082   14.849  1.00 40.05 ?  215  GLU A CD  1 
ATOM   1675 O  OE1 . GLU A 1 214 ? -33.900 7.108   15.408  1.00 43.02 ?  215  GLU A OE1 1 
ATOM   1676 O  OE2 . GLU A 1 214 ? -35.325 6.097   14.073  1.00 49.49 -1 215  GLU A OE2 1 
ATOM   1677 N  N   . GLY A 1 215 ? -30.359 6.426   18.006  1.00 12.04 ?  216  GLY A N   1 
ATOM   1678 C  CA  . GLY A 1 215 ? -29.613 6.497   19.237  1.00 11.78 ?  216  GLY A CA  1 
ATOM   1679 C  C   . GLY A 1 215 ? -28.110 6.429   19.086  1.00 9.04  ?  216  GLY A C   1 
ATOM   1680 O  O   . GLY A 1 215 ? -27.401 6.530   20.092  1.00 10.11 ?  216  GLY A O   1 
ATOM   1681 N  N   . ASN A 1 216 ? -27.598 6.265   17.872  1.00 9.59  ?  217  ASN A N   1 
ATOM   1682 C  CA  . ASN A 1 216 ? -26.171 6.129   17.666  1.00 7.72  ?  217  ASN A CA  1 
ATOM   1683 C  C   . ASN A 1 216 ? -25.575 7.480   17.296  1.00 8.72  ?  217  ASN A C   1 
ATOM   1684 O  O   . ASN A 1 216 ? -25.864 7.990   16.201  1.00 8.23  ?  217  ASN A O   1 
ATOM   1685 C  CB  . ASN A 1 216 ? -25.917 5.105   16.557  1.00 8.42  ?  217  ASN A CB  1 
ATOM   1686 C  CG  . ASN A 1 216 ? -24.446 4.871   16.308  1.00 8.64  ?  217  ASN A CG  1 
ATOM   1687 O  OD1 . ASN A 1 216 ? -23.587 5.570   16.852  1.00 8.48  ?  217  ASN A OD1 1 
ATOM   1688 N  ND2 . ASN A 1 216 ? -24.141 3.867   15.477  1.00 7.83  ?  217  ASN A ND2 1 
ATOM   1689 N  N   . PRO A 1 217 ? -24.750 8.096   18.155  1.00 7.37  ?  218  PRO A N   1 
ATOM   1690 C  CA  . PRO A 1 217 ? -24.188 9.418   17.801  1.00 8.32  ?  218  PRO A CA  1 
ATOM   1691 C  C   . PRO A 1 217 ? -23.305 9.389   16.561  1.00 8.24  ?  218  PRO A C   1 
ATOM   1692 O  O   . PRO A 1 217 ? -23.197 10.409  15.871  1.00 8.10  ?  218  PRO A O   1 
ATOM   1693 C  CB  . PRO A 1 217 ? -23.383 9.816   19.052  1.00 8.48  ?  218  PRO A CB  1 
ATOM   1694 C  CG  . PRO A 1 217 ? -23.039 8.496   19.699  1.00 10.22 ?  218  PRO A CG  1 
ATOM   1695 C  CD  . PRO A 1 217 ? -24.206 7.571   19.422  1.00 8.31  ?  218  PRO A CD  1 
ATOM   1696 N  N   . VAL A 1 218 ? -22.663 8.252   16.265  1.00 8.32  ?  219  VAL A N   1 
ATOM   1697 C  CA  . VAL A 1 218 ? -21.835 8.137   15.066  1.00 7.89  ?  219  VAL A CA  1 
ATOM   1698 C  C   . VAL A 1 218 ? -22.675 8.364   13.819  1.00 8.01  ?  219  VAL A C   1 
ATOM   1699 O  O   . VAL A 1 218 ? -22.263 9.075   12.891  1.00 7.30  ?  219  VAL A O   1 
ATOM   1700 C  CB  . VAL A 1 218 ? -21.150 6.752   15.046  1.00 6.72  ?  219  VAL A CB  1 
ATOM   1701 C  CG1 . VAL A 1 218 ? -20.395 6.528   13.742  1.00 9.37  ?  219  VAL A CG1 1 
ATOM   1702 C  CG2 . VAL A 1 218 ? -20.200 6.628   16.206  1.00 8.54  ?  219  VAL A CG2 1 
ATOM   1703 N  N   . HIS A 1 219 ? -23.863 7.750   13.776  1.00 7.31  ?  220  HIS A N   1 
ATOM   1704 C  CA  . HIS A 1 219 ? -24.749 7.867   12.624  1.00 7.91  ?  220  HIS A CA  1 
ATOM   1705 C  C   . HIS A 1 219 ? -25.387 9.251   12.539  1.00 6.98  ?  220  HIS A C   1 
ATOM   1706 O  O   . HIS A 1 219 ? -25.561 9.790   11.440  1.00 7.92  ?  220  HIS A O   1 
ATOM   1707 C  CB  . HIS A 1 219 ? -25.828 6.786   12.704  1.00 8.37  ?  220  HIS A CB  1 
ATOM   1708 C  CG  . HIS A 1 219 ? -26.905 6.949   11.685  1.00 7.12  ?  220  HIS A CG  1 
ATOM   1709 N  ND1 . HIS A 1 219 ? -26.693 6.747   10.337  1.00 8.01  ?  220  HIS A ND1 1 
ATOM   1710 C  CD2 . HIS A 1 219 ? -28.194 7.339   11.813  1.00 8.87  ?  220  HIS A CD2 1 
ATOM   1711 C  CE1 . HIS A 1 219 ? -27.814 6.992   9.680   1.00 8.67  ?  220  HIS A CE1 1 
ATOM   1712 N  NE2 . HIS A 1 219 ? -28.738 7.360   10.550  1.00 8.83  ?  220  HIS A NE2 1 
ATOM   1713 N  N   . GLU A 1 220 ? -25.765 9.839   13.676  1.00 7.37  ?  221  GLU A N   1 
ATOM   1714 C  CA  . GLU A 1 220 ? -26.242 11.215  13.642  1.00 8.29  ?  221  GLU A CA  1 
ATOM   1715 C  C   . GLU A 1 220 ? -25.228 12.105  12.941  1.00 8.11  ?  221  GLU A C   1 
ATOM   1716 O  O   . GLU A 1 220 ? -25.573 12.898  12.054  1.00 8.17  ?  221  GLU A O   1 
ATOM   1717 C  CB  . GLU A 1 220 ? -26.485 11.720  15.069  1.00 8.90  ?  221  GLU A CB  1 
ATOM   1718 C  CG  . GLU A 1 220 ? -26.925 13.191  15.098  1.00 9.87  ?  221  GLU A CG  1 
ATOM   1719 C  CD  . GLU A 1 220 ? -26.990 13.782  16.501  1.00 12.09 ?  221  GLU A CD  1 
ATOM   1720 O  OE1 . GLU A 1 220 ? -27.188 15.015  16.614  1.00 12.12 ?  221  GLU A OE1 1 
ATOM   1721 O  OE2 . GLU A 1 220 ? -26.879 13.032  17.489  1.00 12.05 -1 221  GLU A OE2 1 
ATOM   1722 N  N   . GLU A 1 221 ? -23.957 11.957  13.314  1.00 8.21  ?  222  GLU A N   1 
ATOM   1723 C  CA  . GLU A 1 221 ? -22.930 12.876  12.852  1.00 8.69  ?  222  GLU A CA  1 
ATOM   1724 C  C   . GLU A 1 221 ? -22.541 12.638  11.399  1.00 7.43  ?  222  GLU A C   1 
ATOM   1725 O  O   . GLU A 1 221 ? -22.378 13.607  10.651  1.00 8.63  ?  222  GLU A O   1 
ATOM   1726 C  CB  . GLU A 1 221 ? -21.720 12.832  13.777  1.00 8.75  ?  222  GLU A CB  1 
ATOM   1727 C  CG  . GLU A 1 221 ? -20.774 14.019  13.606  1.00 8.10  ?  222  GLU A CG  1 
ATOM   1728 C  CD  . GLU A 1 221 ? -21.320 15.359  14.054  1.00 10.67 ?  222  GLU A CD  1 
ATOM   1729 O  OE1 . GLU A 1 221 ? -20.484 16.268  14.142  1.00 13.07 ?  222  GLU A OE1 1 
ATOM   1730 O  OE2 . GLU A 1 221 ? -22.535 15.525  14.306  1.00 11.33 -1 222  GLU A OE2 1 
ATOM   1731 N  N   . ASN A 1 222 ? -22.353 11.374  10.973  1.00 7.34  ?  223  ASN A N   1 
ATOM   1732 C  CA  . ASN A 1 222 ? -21.961 11.187  9.576   1.00 6.86  ?  223  ASN A CA  1 
ATOM   1733 C  C   . ASN A 1 222 ? -23.095 11.538  8.625   1.00 7.90  ?  223  ASN A C   1 
ATOM   1734 O  O   . ASN A 1 222 ? -22.840 12.022  7.517   1.00 8.30  ?  223  ASN A O   1 
ATOM   1735 C  CB  . ASN A 1 222 ? -21.253 9.839   9.294   1.00 8.43  ?  223  ASN A CB  1 
ATOM   1736 C  CG  . ASN A 1 222 ? -22.179 8.616   9.250   1.00 7.36  ?  223  ASN A CG  1 
ATOM   1737 O  OD1 . ASN A 1 222 ? -23.312 8.624   9.716   1.00 8.17  ?  223  ASN A OD1 1 
ATOM   1738 N  ND2 . ASN A 1 222 ? -21.639 7.526   8.715   1.00 9.19  ?  223  ASN A ND2 1 
ATOM   1739 N  N   . THR A 1 223 ? -24.345 11.381  9.070   1.00 7.70  ?  224  THR A N   1 
ATOM   1740 C  CA  . THR A 1 223 ? -25.469 11.870  8.281   1.00 7.28  ?  224  THR A CA  1 
ATOM   1741 C  C   . THR A 1 223 ? -25.447 13.394  8.184   1.00 8.00  ?  224  THR A C   1 
ATOM   1742 O  O   . THR A 1 223 ? -25.621 13.951  7.095   1.00 8.99  ?  224  THR A O   1 
ATOM   1743 C  CB  . THR A 1 223 ? -26.785 11.334  8.853   1.00 8.27  ?  224  THR A CB  1 
ATOM   1744 O  OG1 . THR A 1 223 ? -26.746 9.903   8.803   1.00 8.79  ?  224  THR A OG1 1 
ATOM   1745 C  CG2 . THR A 1 223 ? -27.966 11.806  8.027   1.00 10.06 ?  224  THR A CG2 1 
ATOM   1746 N  N   . ARG A 1 224 ? -25.189 14.086  9.302   1.00 8.83  ?  225  ARG A N   1 
ATOM   1747 C  CA  . ARG A 1 224 ? -25.116 15.549  9.258   1.00 7.99  ?  225  ARG A CA  1 
ATOM   1748 C  C   . ARG A 1 224 ? -24.000 16.018  8.328   1.00 9.59  ?  225  ARG A C   1 
ATOM   1749 O  O   . ARG A 1 224 ? -24.183 16.967  7.551   1.00 9.17  ?  225  ARG A O   1 
ATOM   1750 C  CB  . ARG A 1 224 ? -24.929 16.108  10.670  1.00 10.28 ?  225  ARG A CB  1 
ATOM   1751 C  CG  . ARG A 1 224 ? -26.234 16.206  11.466  1.00 11.23 ?  225  ARG A CG  1 
ATOM   1752 C  CD  . ARG A 1 224 ? -26.016 16.601  12.927  1.00 13.12 ?  225  ARG A CD  1 
ATOM   1753 N  NE  . ARG A 1 224 ? -27.306 16.743  13.596  1.00 12.55 ?  225  ARG A NE  1 
ATOM   1754 C  CZ  . ARG A 1 224 ? -27.502 17.450  14.705  1.00 13.89 ?  225  ARG A CZ  1 
ATOM   1755 N  NH1 . ARG A 1 224 ? -28.720 17.535  15.225  1.00 14.34 ?  225  ARG A NH1 1 
ATOM   1756 N  NH2 . ARG A 1 224 ? -26.482 18.057  15.300  1.00 14.43 ?  225  ARG A NH2 1 
ATOM   1757 N  N   . ILE A 1 225 ? -22.839 15.364  8.381   1.00 8.64  ?  226  ILE A N   1 
ATOM   1758 C  CA  . ILE A 1 225 ? -21.721 15.789  7.540   1.00 9.05  ?  226  ILE A CA  1 
ATOM   1759 C  C   . ILE A 1 225 ? -22.009 15.505  6.068   1.00 9.44  ?  226  ILE A C   1 
ATOM   1760 O  O   . ILE A 1 225 ? -21.753 16.352  5.193   1.00 8.91  ?  226  ILE A O   1 
ATOM   1761 C  CB  . ILE A 1 225 ? -20.416 15.134  8.029   1.00 7.65  ?  226  ILE A CB  1 
ATOM   1762 C  CG1 . ILE A 1 225 ? -20.038 15.750  9.369   1.00 10.61 ?  226  ILE A CG1 1 
ATOM   1763 C  CG2 . ILE A 1 225 ? -19.284 15.335  7.015   1.00 10.09 ?  226  ILE A CG2 1 
ATOM   1764 C  CD1 . ILE A 1 225 ? -18.982 15.006  10.118  1.00 12.15 ?  226  ILE A CD1 1 
ATOM   1765 N  N   . ALA A 1 226 ? -22.577 14.330  5.764   1.00 8.23  ?  227  ALA A N   1 
ATOM   1766 C  CA  . ALA A 1 226 ? -22.941 14.024  4.380   1.00 7.95  ?  227  ALA A CA  1 
ATOM   1767 C  C   . ALA A 1 226 ? -23.961 15.022  3.843   1.00 9.52  ?  227  ALA A C   1 
ATOM   1768 O  O   . ALA A 1 226 ? -23.903 15.404  2.669   1.00 9.60  ?  227  ALA A O   1 
ATOM   1769 C  CB  . ALA A 1 226 ? -23.481 12.595  4.277   1.00 7.67  ?  227  ALA A CB  1 
ATOM   1770 N  N   . ARG A 1 227 ? -24.899 15.463  4.690   1.00 8.64  ?  228  ARG A N   1 
ATOM   1771 C  CA  . ARG A 1 227 ? -25.873 16.465  4.253   1.00 9.92  ?  228  ARG A CA  1 
ATOM   1772 C  C   . ARG A 1 227 ? -25.214 17.790  3.896   1.00 10.48 ?  228  ARG A C   1 
ATOM   1773 O  O   . ARG A 1 227 ? -25.722 18.527  3.043   1.00 12.36 ?  228  ARG A O   1 
ATOM   1774 C  CB  . ARG A 1 227 ? -26.886 16.732  5.363   1.00 11.26 ?  228  ARG A CB  1 
ATOM   1775 C  CG  . ARG A 1 227 ? -27.965 15.686  5.534   1.00 14.03 ?  228  ARG A CG  1 
ATOM   1776 C  CD  . ARG A 1 227 ? -28.817 16.027  6.755   1.00 14.85 ?  228  ARG A CD  1 
ATOM   1777 N  NE  . ARG A 1 227 ? -29.749 14.965  7.117   1.00 14.96 ?  228  ARG A NE  1 
ATOM   1778 C  CZ  . ARG A 1 227 ? -30.272 14.830  8.330   1.00 13.72 ?  228  ARG A CZ  1 
ATOM   1779 N  NH1 . ARG A 1 227 ? -31.119 13.846  8.578   1.00 15.07 ?  228  ARG A NH1 1 
ATOM   1780 N  NH2 . ARG A 1 227 ? -29.946 15.686  9.296   1.00 19.19 ?  228  ARG A NH2 1 
ATOM   1781 N  N   . MET A 1 228 ? -24.103 18.126  4.546   1.00 8.01  ?  229  MET A N   1 
ATOM   1782 C  CA  . MET A 1 228 ? -23.403 19.360  4.201   1.00 9.86  ?  229  MET A CA  1 
ATOM   1783 C  C   . MET A 1 228 ? -22.745 19.287  2.832   1.00 9.74  ?  229  MET A C   1 
ATOM   1784 O  O   . MET A 1 228 ? -22.680 20.305  2.122   1.00 11.27 ?  229  MET A O   1 
ATOM   1785 C  CB  . MET A 1 228 ? -22.372 19.706  5.266   1.00 10.83 ?  229  MET A CB  1 
ATOM   1786 C  CG  . MET A 1 228 ? -22.976 20.002  6.617   1.00 11.32 ?  229  MET A CG  1 
ATOM   1787 S  SD  . MET A 1 228 ? -21.791 19.921  7.954   1.00 19.08 ?  229  MET A SD  1 
ATOM   1788 C  CE  . MET A 1 228 ? -20.801 21.288  7.448   1.00 17.48 ?  229  MET A CE  1 
ATOM   1789 N  N   . ALA A 1 229 ? -22.253 18.105  2.446   1.00 9.18  ?  230  ALA A N   1 
ATOM   1790 C  CA  . ALA A 1 229 ? -21.648 17.944  1.130   1.00 8.86  ?  230  ALA A CA  1 
ATOM   1791 C  C   . ALA A 1 229 ? -22.706 17.758  0.059   1.00 9.11  ?  230  ALA A C   1 
ATOM   1792 O  O   . ALA A 1 229 ? -22.538 18.220  -1.074  1.00 12.26 ?  230  ALA A O   1 
ATOM   1793 C  CB  . ALA A 1 229 ? -20.708 16.732  1.144   1.00 9.94  ?  230  ALA A CB  1 
ATOM   1794 N  N   . GLY A 1 230 ? -23.799 17.090  0.401   1.00 9.12  ?  231  GLY A N   1 
ATOM   1795 C  CA  . GLY A 1 230 ? -24.795 16.701  -0.571  1.00 8.99  ?  231  GLY A CA  1 
ATOM   1796 C  C   . GLY A 1 230 ? -24.428 15.415  -1.295  1.00 8.38  ?  231  GLY A C   1 
ATOM   1797 O  O   . GLY A 1 230 ? -23.277 14.987  -1.331  1.00 8.82  ?  231  GLY A O   1 
ATOM   1798 N  N   . CYS A 1 231 ? -25.454 14.800  -1.880  1.00 9.64  ?  232  CYS A N   1 
ATOM   1799 C  CA  . CYS A 1 231 ? -25.318 13.636  -2.744  1.00 8.58  ?  232  CYS A CA  1 
ATOM   1800 C  C   . CYS A 1 231 ? -26.598 13.563  -3.550  1.00 10.22 ?  232  CYS A C   1 
ATOM   1801 O  O   . CYS A 1 231 ? -27.688 13.571  -2.970  1.00 13.93 ?  232  CYS A O   1 
ATOM   1802 C  CB  . CYS A 1 231 ? -25.166 12.363  -1.915  1.00 11.71 ?  232  CYS A CB  1 
ATOM   1803 S  SG  . CYS A 1 231 ? -24.893 10.883  -2.927  1.00 14.01 ?  232  CYS A SG  1 
ATOM   1804 N  N   . ASP A 1 232 ? -26.480 13.496  -4.868  1.00 7.95  ?  233  ASP A N   1 
ATOM   1805 C  CA  . ASP A 1 232 ? -27.676 13.549  -5.694  1.00 9.79  ?  233  ASP A CA  1 
ATOM   1806 C  C   . ASP A 1 232 ? -28.353 12.205  -5.868  1.00 9.46  ?  233  ASP A C   1 
ATOM   1807 O  O   . ASP A 1 232 ? -29.560 12.168  -6.123  1.00 11.05 ?  233  ASP A O   1 
ATOM   1808 C  CB  . ASP A 1 232 ? -27.347 14.148  -7.054  1.00 10.67 ?  233  ASP A CB  1 
ATOM   1809 C  CG  . ASP A 1 232 ? -26.736 15.534  -6.927  1.00 14.14 ?  233  ASP A CG  1 
ATOM   1810 O  OD1 . ASP A 1 232 ? -27.357 16.414  -6.273  1.00 19.75 ?  233  ASP A OD1 1 
ATOM   1811 O  OD2 . ASP A 1 232 ? -25.624 15.744  -7.438  1.00 13.12 -1 233  ASP A OD2 1 
ATOM   1812 N  N   . PHE A 1 233 ? -27.625 11.102  -5.725  1.00 7.75  ?  234  PHE A N   1 
ATOM   1813 C  CA  . PHE A 1 233 ? -28.207 9.811   -6.056  1.00 7.06  ?  234  PHE A CA  1 
ATOM   1814 C  C   . PHE A 1 233 ? -27.321 8.719   -5.484  1.00 8.30  ?  234  PHE A C   1 
ATOM   1815 O  O   . PHE A 1 233 ? -26.096 8.784   -5.623  1.00 8.79  ?  234  PHE A O   1 
ATOM   1816 C  CB  . PHE A 1 233 ? -28.280 9.668   -7.581  1.00 7.69  ?  234  PHE A CB  1 
ATOM   1817 C  CG  . PHE A 1 233 ? -29.256 8.634   -8.052  1.00 7.29  ?  234  PHE A CG  1 
ATOM   1818 C  CD1 . PHE A 1 233 ? -30.586 8.971   -8.275  1.00 9.35  ?  234  PHE A CD1 1 
ATOM   1819 C  CD2 . PHE A 1 233 ? -28.843 7.332   -8.301  1.00 8.74  ?  234  PHE A CD2 1 
ATOM   1820 C  CE1 . PHE A 1 233 ? -31.492 8.016   -8.722  1.00 9.75  ?  234  PHE A CE1 1 
ATOM   1821 C  CE2 . PHE A 1 233 ? -29.740 6.388   -8.745  1.00 9.63  ?  234  PHE A CE2 1 
ATOM   1822 C  CZ  . PHE A 1 233 ? -31.062 6.731   -8.966  1.00 9.92  ?  234  PHE A CZ  1 
ATOM   1823 N  N   . ILE A 1 234 ? -27.940 7.717   -4.849  1.00 7.39  ?  235  ILE A N   1 
ATOM   1824 C  CA  . ILE A 1 234 ? -27.210 6.540   -4.400  1.00 7.58  ?  235  ILE A CA  1 
ATOM   1825 C  C   . ILE A 1 234 ? -27.795 5.289   -5.037  1.00 7.80  ?  235  ILE A C   1 
ATOM   1826 O  O   . ILE A 1 234 ? -28.960 5.249   -5.443  1.00 7.78  ?  235  ILE A O   1 
ATOM   1827 C  CB  . ILE A 1 234 ? -27.158 6.395   -2.862  1.00 7.44  ?  235  ILE A CB  1 
ATOM   1828 C  CG1 . ILE A 1 234 ? -28.505 5.950   -2.278  1.00 9.07  ?  235  ILE A CG1 1 
ATOM   1829 C  CG2 . ILE A 1 234 ? -26.666 7.695   -2.224  1.00 8.74  ?  235  ILE A CG2 1 
ATOM   1830 C  CD1 . ILE A 1 234 ? -28.380 5.428   -0.838  1.00 9.46  ?  235  ILE A CD1 1 
ATOM   1831 N  N   . VAL A 1 235 ? -26.956 4.257   -5.123  1.00 6.72  ?  236  VAL A N   1 
ATOM   1832 C  CA  . VAL A 1 235 ? -27.399 2.888   -5.360  1.00 7.68  ?  236  VAL A CA  1 
ATOM   1833 C  C   . VAL A 1 235 ? -26.721 2.035   -4.297  1.00 7.17  ?  236  VAL A C   1 
ATOM   1834 O  O   . VAL A 1 235 ? -25.488 2.014   -4.210  1.00 7.57  ?  236  VAL A O   1 
ATOM   1835 C  CB  . VAL A 1 235 ? -27.012 2.378   -6.760  1.00 7.19  ?  236  VAL A CB  1 
ATOM   1836 C  CG1 . VAL A 1 235 ? -27.491 0.936   -6.940  1.00 9.71  ?  236  VAL A CG1 1 
ATOM   1837 C  CG2 . VAL A 1 235 ? -27.542 3.298   -7.851  1.00 9.36  ?  236  VAL A CG2 1 
ATOM   1838 N  N   . ASN A 1 236 ? -27.510 1.319   -3.493  1.00 6.88  ?  237  ASN A N   1 
ATOM   1839 C  CA  . ASN A 1 236 ? -26.944 0.429   -2.491  1.00 7.29  ?  237  ASN A CA  1 
ATOM   1840 C  C   . ASN A 1 236 ? -27.568 -0.956  -2.652  1.00 8.09  ?  237  ASN A C   1 
ATOM   1841 O  O   . ASN A 1 236 ? -28.716 -1.090  -3.091  1.00 7.93  ?  237  ASN A O   1 
ATOM   1842 C  CB  . ASN A 1 236 ? -27.269 0.889   -1.064  1.00 7.55  ?  237  ASN A CB  1 
ATOM   1843 C  CG  . ASN A 1 236 ? -26.407 2.072   -0.551  1.00 7.97  ?  237  ASN A CG  1 
ATOM   1844 O  OD1 . ASN A 1 236 ? -26.571 2.456   0.606   1.00 8.01  ?  237  ASN A OD1 1 
ATOM   1845 N  ND2 . ASN A 1 236 ? -25.516 2.641   -1.377  1.00 8.10  ?  237  ASN A ND2 1 
ATOM   1846 N  N   . VAL A 1 237 ? -26.816 -1.989  -2.268  1.00 6.96  ?  238  VAL A N   1 
ATOM   1847 C  CA  . VAL A 1 237 ? -27.296 -3.371  -2.304  1.00 8.31  ?  238  VAL A CA  1 
ATOM   1848 C  C   . VAL A 1 237 ? -27.108 -4.028  -0.939  1.00 7.44  ?  238  VAL A C   1 
ATOM   1849 O  O   . VAL A 1 237 ? -26.334 -3.568  -0.093  1.00 8.13  ?  238  VAL A O   1 
ATOM   1850 C  CB  . VAL A 1 237 ? -26.607 -4.225  -3.404  1.00 8.72  ?  238  VAL A CB  1 
ATOM   1851 C  CG1 . VAL A 1 237 ? -26.920 -3.679  -4.784  1.00 10.09 ?  238  VAL A CG1 1 
ATOM   1852 C  CG2 . VAL A 1 237 ? -25.106 -4.322  -3.165  1.00 10.90 ?  238  VAL A CG2 1 
ATOM   1853 N  N   . THR A 1 238 ? -27.836 -5.133  -0.741  1.00 8.00  ?  239  THR A N   1 
ATOM   1854 C  CA  . THR A 1 238 ? -27.578 -6.074  0.336   1.00 7.44  ?  239  THR A CA  1 
ATOM   1855 C  C   . THR A 1 238 ? -27.195 -7.410  -0.285  1.00 7.79  ?  239  THR A C   1 
ATOM   1856 O  O   . THR A 1 238 ? -27.624 -7.730  -1.399  1.00 7.99  ?  239  THR A O   1 
ATOM   1857 C  CB  . THR A 1 238 ? -28.801 -6.281  1.239   1.00 8.95  ?  239  THR A CB  1 
ATOM   1858 O  OG1 . THR A 1 238 ? -29.923 -6.692  0.442   1.00 9.91  ?  239  THR A OG1 1 
ATOM   1859 C  CG2 . THR A 1 238 ? -29.129 -4.979  1.983   1.00 10.84 ?  239  THR A CG2 1 
ATOM   1860 N  N   . LEU A 1 239 ? -26.395 -8.188  0.445   1.00 8.60  ?  240  LEU A N   1 
ATOM   1861 C  CA  . LEU A 1 239 ? -25.870 -9.470  -0.013  1.00 8.21  ?  240  LEU A CA  1 
ATOM   1862 C  C   . LEU A 1 239 ? -26.200 -10.556 0.994   1.00 9.10  ?  240  LEU A C   1 
ATOM   1863 O  O   . LEU A 1 239 ? -26.083 -10.345 2.202   1.00 10.52 ?  240  LEU A O   1 
ATOM   1864 C  CB  . LEU A 1 239 ? -24.343 -9.433  -0.102  1.00 10.46 ?  240  LEU A CB  1 
ATOM   1865 C  CG  . LEU A 1 239 ? -23.741 -8.449  -1.105  1.00 9.40  ?  240  LEU A CG  1 
ATOM   1866 C  CD1 . LEU A 1 239 ? -22.217 -8.472  -1.020  1.00 11.07 ?  240  LEU A CD1 1 
ATOM   1867 C  CD2 . LEU A 1 239 ? -24.206 -8.730  -2.536  1.00 11.26 ?  240  LEU A CD2 1 
ATOM   1868 N  N   . ASP A 1 240 ? -26.543 -11.745 0.503   1.00 8.54  ?  241  ASP A N   1 
ATOM   1869 C  CA  . ASP A 1 240 ? -26.755 -12.860 1.420   1.00 10.14 ?  241  ASP A CA  1 
ATOM   1870 C  C   . ASP A 1 240 ? -25.427 -13.533 1.762   1.00 11.63 ?  241  ASP A C   1 
ATOM   1871 O  O   . ASP A 1 240 ? -24.353 -13.085 1.353   1.00 10.27 ?  241  ASP A O   1 
ATOM   1872 C  CB  . ASP A 1 240 ? -27.861 -13.792 0.915   1.00 11.73 ?  241  ASP A CB  1 
ATOM   1873 C  CG  . ASP A 1 240 ? -27.462 -14.616 -0.305  1.00 12.28 ?  241  ASP A CG  1 
ATOM   1874 O  OD1 . ASP A 1 240 ? -26.278 -14.653 -0.701  1.00 9.87  ?  241  ASP A OD1 1 
ATOM   1875 O  OD2 . ASP A 1 240 ? -28.383 -15.225 -0.898  1.00 13.21 -1 241  ASP A OD2 1 
ATOM   1876 N  N   . GLY A 1 241 ? -25.495 -14.641 2.511   1.00 11.18 ?  242  GLY A N   1 
ATOM   1877 C  CA  . GLY A 1 241 ? -24.272 -15.305 2.940   1.00 13.55 ?  242  GLY A CA  1 
ATOM   1878 C  C   . GLY A 1 241 ? -23.415 -15.803 1.792   1.00 14.31 ?  242  GLY A C   1 
ATOM   1879 O  O   . GLY A 1 241 ? -22.186 -15.860 1.908   1.00 15.57 ?  242  GLY A O   1 
ATOM   1880 N  N   . ALA A 1 242 ? -24.040 -16.161 0.669   1.00 10.36 ?  243  ALA A N   1 
ATOM   1881 C  CA  . ALA A 1 242 ? -23.329 -16.609 -0.515  1.00 11.66 ?  243  ALA A CA  1 
ATOM   1882 C  C   . ALA A 1 242 ? -22.971 -15.473 -1.458  1.00 10.88 ?  243  ALA A C   1 
ATOM   1883 O  O   . ALA A 1 242 ? -22.497 -15.733 -2.569  1.00 12.18 ?  243  ALA A O   1 
ATOM   1884 C  CB  . ALA A 1 242 ? -24.158 -17.651 -1.267  1.00 13.09 ?  243  ALA A CB  1 
ATOM   1885 N  N   . ARG A 1 243 ? -23.187 -14.227 -1.039  1.00 9.52  ?  244  ARG A N   1 
ATOM   1886 C  CA  . ARG A 1 243 ? -22.835 -13.024 -1.794  1.00 10.38 ?  244  ARG A CA  1 
ATOM   1887 C  C   . ARG A 1 243 ? -23.760 -12.760 -2.974  1.00 11.10 ?  244  ARG A C   1 
ATOM   1888 O  O   . ARG A 1 243 ? -23.368 -12.067 -3.919  1.00 14.45 ?  244  ARG A O   1 
ATOM   1889 C  CB  . ARG A 1 243 ? -21.360 -12.981 -2.226  1.00 12.16 ?  244  ARG A CB  1 
ATOM   1890 C  CG  . ARG A 1 243 ? -20.330 -13.154 -1.110  1.00 13.46 ?  244  ARG A CG  1 
ATOM   1891 C  CD  . ARG A 1 243 ? -20.048 -11.882 -0.330  1.00 14.83 ?  244  ARG A CD  1 
ATOM   1892 N  NE  . ARG A 1 243 ? -19.222 -12.180 0.852   1.00 12.05 ?  244  ARG A NE  1 
ATOM   1893 C  CZ  . ARG A 1 243 ? -17.892 -12.110 0.898   1.00 11.21 ?  244  ARG A CZ  1 
ATOM   1894 N  NH1 . ARG A 1 243 ? -17.192 -11.728 -0.165  1.00 11.89 ?  244  ARG A NH1 1 
ATOM   1895 N  NH2 . ARG A 1 243 ? -17.254 -12.413 2.029   1.00 12.07 ?  244  ARG A NH2 1 
ATOM   1896 N  N   . ARG A 1 244 ? -24.976 -13.300 -2.960  1.00 10.34 ?  245  ARG A N   1 
ATOM   1897 C  CA  A ARG A 1 244 ? -25.976 -12.925 -3.950  0.49 10.25 ?  245  ARG A CA  1 
ATOM   1898 C  CA  B ARG A 1 244 ? -25.977 -12.932 -3.954  0.51 10.25 ?  245  ARG A CA  1 
ATOM   1899 C  C   . ARG A 1 244 ? -26.705 -11.672 -3.496  1.00 8.26  ?  245  ARG A C   1 
ATOM   1900 O  O   . ARG A 1 244 ? -27.041 -11.529 -2.317  1.00 8.44  ?  245  ARG A O   1 
ATOM   1901 C  CB  A ARG A 1 244 ? -26.986 -14.057 -4.156  0.49 10.10 ?  245  ARG A CB  1 
ATOM   1902 C  CB  B ARG A 1 244 ? -27.012 -14.042 -4.140  0.51 10.06 ?  245  ARG A CB  1 
ATOM   1903 C  CG  A ARG A 1 244 ? -26.486 -15.219 -5.013  0.49 16.28 ?  245  ARG A CG  1 
ATOM   1904 C  CG  B ARG A 1 244 ? -26.518 -15.267 -4.898  0.51 16.23 ?  245  ARG A CG  1 
ATOM   1905 C  CD  A ARG A 1 244 ? -26.297 -16.520 -4.258  0.49 16.25 ?  245  ARG A CD  1 
ATOM   1906 C  CD  B ARG A 1 244 ? -26.480 -15.072 -6.417  0.51 15.05 ?  245  ARG A CD  1 
ATOM   1907 N  NE  A ARG A 1 244 ? -27.243 -16.715 -3.164  0.49 13.34 ?  245  ARG A NE  1 
ATOM   1908 N  NE  B ARG A 1 244 ? -27.736 -14.660 -7.051  0.51 13.94 ?  245  ARG A NE  1 
ATOM   1909 C  CZ  A ARG A 1 244 ? -27.947 -17.822 -2.965  0.49 11.40 ?  245  ARG A CZ  1 
ATOM   1910 C  CZ  B ARG A 1 244 ? -28.397 -15.384 -7.949  0.51 15.44 ?  245  ARG A CZ  1 
ATOM   1911 N  NH1 A ARG A 1 244 ? -27.869 -18.830 -3.826  0.49 16.99 ?  245  ARG A NH1 1 
ATOM   1912 N  NH1 B ARG A 1 244 ? -27.963 -16.591 -8.278  0.51 16.76 ?  245  ARG A NH1 1 
ATOM   1913 N  NH2 A ARG A 1 244 ? -28.748 -17.908 -1.916  0.49 8.64  ?  245  ARG A NH2 1 
ATOM   1914 N  NH2 B ARG A 1 244 ? -29.509 -14.916 -8.496  0.51 12.06 ?  245  ARG A NH2 1 
ATOM   1915 N  N   . ILE A 1 245 ? -26.948 -10.756 -4.435  1.00 7.96  ?  246  ILE A N   1 
ATOM   1916 C  CA  . ILE A 1 245 ? -27.702 -9.546  -4.116  1.00 7.46  ?  246  ILE A CA  1 
ATOM   1917 C  C   . ILE A 1 245 ? -29.140 -9.917  -3.778  1.00 7.49  ?  246  ILE A C   1 
ATOM   1918 O  O   . ILE A 1 245 ? -29.817 -10.614 -4.545  1.00 8.90  ?  246  ILE A O   1 
ATOM   1919 C  CB  . ILE A 1 245 ? -27.645 -8.570  -5.297  1.00 7.52  ?  246  ILE A CB  1 
ATOM   1920 C  CG1 . ILE A 1 245 ? -26.217 -8.030  -5.469  1.00 10.10 ?  246  ILE A CG1 1 
ATOM   1921 C  CG2 . ILE A 1 245 ? -28.651 -7.431  -5.099  1.00 8.61  ?  246  ILE A CG2 1 
ATOM   1922 C  CD1 . ILE A 1 245 ? -26.066 -7.133  -6.695  1.00 12.39 ?  246  ILE A CD1 1 
ATOM   1923 N  N   . THR A 1 246 ? -29.611 -9.463  -2.617  1.00 7.17  ?  247  THR A N   1 
ATOM   1924 C  CA  . THR A 1 246 ? -30.970 -9.710  -2.166  1.00 8.64  ?  247  THR A CA  1 
ATOM   1925 C  C   . THR A 1 246 ? -31.867 -8.482  -2.225  1.00 9.60  ?  247  THR A C   1 
ATOM   1926 O  O   . THR A 1 246 ? -33.089 -8.629  -2.106  1.00 12.29 ?  247  THR A O   1 
ATOM   1927 C  CB  . THR A 1 246 ? -30.968 -10.282 -0.744  1.00 9.06  ?  247  THR A CB  1 
ATOM   1928 O  OG1 . THR A 1 246 ? -30.088 -9.504  0.086   1.00 9.41  ?  247  THR A OG1 1 
ATOM   1929 C  CG2 . THR A 1 246 ? -30.505 -11.742 -0.772  1.00 9.29  ?  247  THR A CG2 1 
ATOM   1930 N  N   . SER A 1 247 ? -31.306 -7.279  -2.395  1.00 7.51  ?  248  SER A N   1 
ATOM   1931 C  CA  . SER A 1 247 ? -32.096 -6.069  -2.585  1.00 8.59  ?  248  SER A CA  1 
ATOM   1932 C  C   . SER A 1 247 ? -31.230 -5.007  -3.243  1.00 7.79  ?  248  SER A C   1 
ATOM   1933 O  O   . SER A 1 247 ? -29.995 -5.009  -3.110  1.00 7.90  ?  248  SER A O   1 
ATOM   1934 C  CB  . SER A 1 247 ? -32.684 -5.527  -1.276  1.00 11.69 ?  248  SER A CB  1 
ATOM   1935 O  OG  . SER A 1 247 ? -31.700 -4.877  -0.501  1.00 11.84 ?  248  SER A OG  1 
ATOM   1936 N  N   . VAL A 1 248 ? -31.911 -4.121  -3.976  1.00 9.25  ?  249  VAL A N   1 
ATOM   1937 C  CA  . VAL A 1 248 ? -31.338 -2.927  -4.583  1.00 7.54  ?  249  VAL A CA  1 
ATOM   1938 C  C   . VAL A 1 248 ? -32.206 -1.751  -4.161  1.00 9.12  ?  249  VAL A C   1 
ATOM   1939 O  O   . VAL A 1 248 ? -33.435 -1.825  -4.255  1.00 10.40 ?  249  VAL A O   1 
ATOM   1940 C  CB  . VAL A 1 248 ? -31.347 -3.038  -6.120  1.00 9.40  ?  249  VAL A CB  1 
ATOM   1941 C  CG1 . VAL A 1 248 ? -30.996 -1.709  -6.761  1.00 10.96 ?  249  VAL A CG1 1 
ATOM   1942 C  CG2 . VAL A 1 248 ? -30.427 -4.167  -6.613  1.00 10.46 ?  249  VAL A CG2 1 
ATOM   1943 N  N   . VAL A 1 249 ? -31.577 -0.672  -3.690  1.00 7.76  ?  250  VAL A N   1 
ATOM   1944 C  CA  . VAL A 1 249 ? -32.270 0.591   -3.441  1.00 8.56  ?  250  VAL A CA  1 
ATOM   1945 C  C   . VAL A 1 249 ? -31.533 1.686   -4.196  1.00 9.40  ?  250  VAL A C   1 
ATOM   1946 O  O   . VAL A 1 249 ? -30.298 1.678   -4.266  1.00 9.90  ?  250  VAL A O   1 
ATOM   1947 C  CB  . VAL A 1 249 ? -32.373 0.924   -1.931  1.00 9.39  ?  250  VAL A CB  1 
ATOM   1948 C  CG1 . VAL A 1 249 ? -33.255 -0.096  -1.219  1.00 10.49 ?  250  VAL A CG1 1 
ATOM   1949 C  CG2 . VAL A 1 249 ? -30.992 1.026   -1.270  1.00 10.60 ?  250  VAL A CG2 1 
ATOM   1950 N  N   . ALA A 1 250 ? -32.280 2.615   -4.783  1.00 8.97  ?  251  ALA A N   1 
ATOM   1951 C  CA  . ALA A 1 250 ? -31.654 3.720   -5.493  1.00 8.06  ?  251  ALA A CA  1 
ATOM   1952 C  C   . ALA A 1 250 ? -32.465 4.984   -5.287  1.00 9.42  ?  251  ALA A C   1 
ATOM   1953 O  O   . ALA A 1 250 ? -33.692 4.932   -5.165  1.00 9.75  ?  251  ALA A O   1 
ATOM   1954 C  CB  . ALA A 1 250 ? -31.529 3.439   -6.995  1.00 10.70 ?  251  ALA A CB  1 
ATOM   1955 N  N   . GLY A 1 251 ? -31.770 6.126   -5.273  1.00 8.00  ?  252  GLY A N   1 
ATOM   1956 C  CA  . GLY A 1 251 ? -32.429 7.416   -5.166  1.00 8.45  ?  252  GLY A CA  1 
ATOM   1957 C  C   . GLY A 1 251 ? -31.839 8.286   -4.083  1.00 9.00  ?  252  GLY A C   1 
ATOM   1958 O  O   . GLY A 1 251 ? -30.615 8.384   -3.955  1.00 8.71  ?  252  GLY A O   1 
ATOM   1959 N  N   . ASP A 1 252 ? -32.713 8.915   -3.296  1.00 9.85  ?  253  ASP A N   1 
ATOM   1960 C  CA  . ASP A 1 252 ? -32.286 9.863   -2.280  1.00 9.87  ?  253  ASP A CA  1 
ATOM   1961 C  C   . ASP A 1 252 ? -31.326 9.214   -1.280  1.00 8.65  ?  253  ASP A C   1 
ATOM   1962 O  O   . ASP A 1 252 ? -31.548 8.096   -0.813  1.00 8.87  ?  253  ASP A O   1 
ATOM   1963 C  CB  . ASP A 1 252 ? -33.526 10.385  -1.560  1.00 9.50  ?  253  ASP A CB  1 
ATOM   1964 C  CG  . ASP A 1 252 ? -33.190 11.381  -0.491  1.00 10.68 ?  253  ASP A CG  1 
ATOM   1965 O  OD1 . ASP A 1 252 ? -32.932 12.549  -0.836  1.00 13.38 ?  253  ASP A OD1 1 
ATOM   1966 O  OD2 . ASP A 1 252 ? -33.172 10.988  0.697   1.00 11.29 -1 253  ASP A OD2 1 
ATOM   1967 N  N   . MET A 1 253 ? -30.264 9.946   -0.930  1.00 8.88  ?  254  MET A N   1 
ATOM   1968 C  CA  . MET A 1 253 ? -29.222 9.392   -0.067  1.00 8.08  ?  254  MET A CA  1 
ATOM   1969 C  C   . MET A 1 253 ? -29.782 8.894   1.261   1.00 9.45  ?  254  MET A C   1 
ATOM   1970 O  O   . MET A 1 253 ? -29.367 7.840   1.755   1.00 11.05 ?  254  MET A O   1 
ATOM   1971 C  CB  . MET A 1 253 ? -28.077 10.395  0.117   1.00 10.58 ?  254  MET A CB  1 
ATOM   1972 C  CG  . MET A 1 253 ? -26.983 9.943   1.072   1.00 10.94 ?  254  MET A CG  1 
ATOM   1973 S  SD  . MET A 1 253 ? -25.950 11.318  1.611   1.00 14.05 ?  254  MET A SD  1 
ATOM   1974 C  CE  . MET A 1 253 ? -26.963 11.982  2.937   1.00 19.71 ?  254  MET A CE  1 
ATOM   1975 N  N   . GLU A 1 254 ? -30.745 9.610   1.841   1.00 9.21  ?  255  GLU A N   1 
ATOM   1976 C  CA  . GLU A 1 254 ? -31.317 9.152   3.099   1.00 8.75  ?  255  GLU A CA  1 
ATOM   1977 C  C   . GLU A 1 254 ? -32.457 8.157   2.898   1.00 9.10  ?  255  GLU A C   1 
ATOM   1978 O  O   . GLU A 1 254 ? -32.442 7.072   3.493   1.00 10.66 ?  255  GLU A O   1 
ATOM   1979 C  CB  . GLU A 1 254 ? -31.742 10.351  3.947   1.00 12.07 ?  255  GLU A CB  1 
ATOM   1980 C  CG  . GLU A 1 254 ? -30.544 11.091  4.470   1.00 12.27 ?  255  GLU A CG  1 
ATOM   1981 C  CD  . GLU A 1 254 ? -30.915 12.207  5.406   1.00 15.56 ?  255  GLU A CD  1 
ATOM   1982 O  OE1 . GLU A 1 254 ? -30.755 13.385  5.025   1.00 17.70 ?  255  GLU A OE1 1 
ATOM   1983 O  OE2 . GLU A 1 254 ? -31.394 11.892  6.518   1.00 17.51 -1 255  GLU A OE2 1 
ATOM   1984 N  N   . GLN A 1 255 ? -33.435 8.485   2.044   1.00 10.32 ?  256  GLN A N   1 
ATOM   1985 C  CA  . GLN A 1 255 ? -34.609 7.622   1.916   1.00 11.57 ?  256  GLN A CA  1 
ATOM   1986 C  C   . GLN A 1 255 ? -34.245 6.253   1.349   1.00 10.59 ?  256  GLN A C   1 
ATOM   1987 O  O   . GLN A 1 255 ? -34.763 5.226   1.806   1.00 11.45 ?  256  GLN A O   1 
ATOM   1988 C  CB  . GLN A 1 255 ? -35.684 8.296   1.064   1.00 13.33 ?  256  GLN A CB  1 
ATOM   1989 C  CG  . GLN A 1 255 ? -36.246 9.584   1.675   1.00 16.78 ?  256  GLN A CG  1 
ATOM   1990 C  CD  . GLN A 1 255 ? -37.120 10.357  0.699   1.00 20.85 ?  256  GLN A CD  1 
ATOM   1991 O  OE1 . GLN A 1 255 ? -38.038 9.796   0.108   1.00 23.09 ?  256  GLN A OE1 1 
ATOM   1992 N  NE2 . GLN A 1 255 ? -36.830 11.644  0.527   1.00 24.13 ?  256  GLN A NE2 1 
ATOM   1993 N  N   . ALA A 1 256 ? -33.364 6.212   0.348   1.00 9.53  ?  257  ALA A N   1 
ATOM   1994 C  CA  . ALA A 1 256 ? -32.985 4.915   -0.207  1.00 10.14 ?  257  ALA A CA  1 
ATOM   1995 C  C   . ALA A 1 256 ? -32.211 4.090   0.810   1.00 9.54  ?  257  ALA A C   1 
ATOM   1996 O  O   . ALA A 1 256 ? -32.470 2.896   0.976   1.00 10.01 ?  257  ALA A O   1 
ATOM   1997 C  CB  . ALA A 1 256 ? -32.178 5.086   -1.496  1.00 9.71  ?  257  ALA A CB  1 
ATOM   1998 N  N   . PHE A 1 257 ? -31.269 4.721   1.512   1.00 9.74  ?  258  PHE A N   1 
ATOM   1999 C  CA  . PHE A 1 257 ? -30.485 4.016   2.519   1.00 9.25  ?  258  PHE A CA  1 
ATOM   2000 C  C   . PHE A 1 257 ? -31.383 3.418   3.597   1.00 10.30 ?  258  PHE A C   1 
ATOM   2001 O  O   . PHE A 1 257 ? -31.239 2.242   3.961   1.00 8.89  ?  258  PHE A O   1 
ATOM   2002 C  CB  . PHE A 1 257 ? -29.471 4.985   3.129   1.00 9.89  ?  258  PHE A CB  1 
ATOM   2003 C  CG  . PHE A 1 257 ? -28.747 4.439   4.329   1.00 7.74  ?  258  PHE A CG  1 
ATOM   2004 C  CD1 . PHE A 1 257 ? -27.852 3.390   4.183   1.00 8.32  ?  258  PHE A CD1 1 
ATOM   2005 C  CD2 . PHE A 1 257 ? -28.951 4.965   5.594   1.00 8.75  ?  258  PHE A CD2 1 
ATOM   2006 C  CE1 . PHE A 1 257 ? -27.184 2.874   5.280   1.00 8.76  ?  258  PHE A CE1 1 
ATOM   2007 C  CE2 . PHE A 1 257 ? -28.274 4.464   6.691   1.00 9.93  ?  258  PHE A CE2 1 
ATOM   2008 C  CZ  . PHE A 1 257 ? -27.394 3.412   6.533   1.00 8.79  ?  258  PHE A CZ  1 
ATOM   2009 N  N   . LEU A 1 258 ? -32.330 4.211   4.110   1.00 10.24 ?  259  LEU A N   1 
ATOM   2010 C  CA  . LEU A 1 258 ? -33.186 3.706   5.177   1.00 10.42 ?  259  LEU A CA  1 
ATOM   2011 C  C   . LEU A 1 258 ? -34.077 2.564   4.698   1.00 10.30 ?  259  LEU A C   1 
ATOM   2012 O  O   . LEU A 1 258 ? -34.365 1.643   5.471   1.00 10.44 ?  259  LEU A O   1 
ATOM   2013 C  CB  . LEU A 1 258 ? -34.005 4.847   5.776   1.00 11.56 ?  259  LEU A CB  1 
ATOM   2014 C  CG  . LEU A 1 258 ? -33.151 5.825   6.590   1.00 12.49 ?  259  LEU A CG  1 
ATOM   2015 C  CD1 . LEU A 1 258 ? -34.026 6.940   7.150   1.00 16.87 ?  259  LEU A CD1 1 
ATOM   2016 C  CD2 . LEU A 1 258 ? -32.388 5.113   7.707   1.00 14.66 ?  259  LEU A CD2 1 
ATOM   2017 N  N   . LYS A 1 259 ? -34.506 2.593   3.433   1.00 11.06 ?  260  LYS A N   1 
ATOM   2018 C  CA  . LYS A 1 259 ? -35.259 1.469   2.891   1.00 10.79 ?  260  LYS A CA  1 
ATOM   2019 C  C   . LYS A 1 259 ? -34.391 0.214   2.820   1.00 10.02 ?  260  LYS A C   1 
ATOM   2020 O  O   . LYS A 1 259 ? -34.847 -0.885  3.162   1.00 11.49 ?  260  LYS A O   1 
ATOM   2021 C  CB  . LYS A 1 259 ? -35.851 1.835   1.525   1.00 11.36 ?  260  LYS A CB  1 
ATOM   2022 C  CG  . LYS A 1 259 ? -36.696 0.710   0.935   1.00 16.79 ?  260  LYS A CG  1 
ATOM   2023 C  CD  . LYS A 1 259 ? -37.274 1.063   -0.413  1.00 25.19 ?  260  LYS A CD  1 
ATOM   2024 C  CE  . LYS A 1 259 ? -37.415 -0.167  -1.296  1.00 31.71 ?  260  LYS A CE  1 
ATOM   2025 N  NZ  . LYS A 1 259 ? -37.762 0.214   -2.694  1.00 35.37 ?  260  LYS A NZ  1 
ATOM   2026 N  N   . GLY A 1 260 ? -33.126 0.362   2.410   1.00 9.92  ?  261  GLY A N   1 
ATOM   2027 C  CA  . GLY A 1 260 ? -32.227 -0.780  2.395   1.00 8.84  ?  261  GLY A CA  1 
ATOM   2028 C  C   . GLY A 1 260 ? -31.950 -1.319  3.787   1.00 8.63  ?  261  GLY A C   1 
ATOM   2029 O  O   . GLY A 1 260 ? -31.873 -2.534  3.986   1.00 9.29  ?  261  GLY A O   1 
ATOM   2030 N  N   . VAL A 1 261 ? -31.790 -0.427  4.769   1.00 8.49  ?  262  VAL A N   1 
ATOM   2031 C  CA  . VAL A 1 261 ? -31.606 -0.867  6.149   1.00 10.02 ?  262  VAL A CA  1 
ATOM   2032 C  C   . VAL A 1 261 ? -32.836 -1.616  6.644   1.00 10.11 ?  262  VAL A C   1 
ATOM   2033 O  O   . VAL A 1 261 ? -32.718 -2.646  7.319   1.00 9.95  ?  262  VAL A O   1 
ATOM   2034 C  CB  . VAL A 1 261 ? -31.260 0.325   7.060   1.00 8.97  ?  262  VAL A CB  1 
ATOM   2035 C  CG1 . VAL A 1 261 ? -31.358 -0.081  8.536   1.00 11.09 ?  262  VAL A CG1 1 
ATOM   2036 C  CG2 . VAL A 1 261 ? -29.878 0.854   6.713   1.00 10.20 ?  262  VAL A CG2 1 
ATOM   2037 N  N   . ALA A 1 262 ? -34.029 -1.113  6.325   1.00 9.83  ?  263  ALA A N   1 
ATOM   2038 C  CA  . ALA A 1 262 ? -35.246 -1.821  6.716   1.00 11.44 ?  263  ALA A CA  1 
ATOM   2039 C  C   . ALA A 1 262 ? -35.247 -3.238  6.162   1.00 11.29 ?  263  ALA A C   1 
ATOM   2040 O  O   . ALA A 1 262 ? -35.626 -4.189  6.858   1.00 13.20 ?  263  ALA A O   1 
ATOM   2041 C  CB  . ALA A 1 262 ? -36.477 -1.056  6.237   1.00 13.10 ?  263  ALA A CB  1 
ATOM   2042 N  N   . PHE A 1 263 ? -34.793 -3.409  4.922   1.00 10.19 ?  264  PHE A N   1 
ATOM   2043 C  CA  . PHE A 1 263 ? -34.699 -4.756  4.382   1.00 9.76  ?  264  PHE A CA  1 
ATOM   2044 C  C   . PHE A 1 263 ? -33.671 -5.587  5.141   1.00 10.37 ?  264  PHE A C   1 
ATOM   2045 O  O   . PHE A 1 263 ? -33.940 -6.734  5.511   1.00 11.41 ?  264  PHE A O   1 
ATOM   2046 C  CB  . PHE A 1 263 ? -34.352 -4.744  2.896   1.00 10.68 ?  264  PHE A CB  1 
ATOM   2047 C  CG  . PHE A 1 263 ? -34.213 -6.135  2.336   1.00 10.83 ?  264  PHE A CG  1 
ATOM   2048 C  CD1 . PHE A 1 263 ? -35.341 -6.871  2.012   1.00 16.80 ?  264  PHE A CD1 1 
ATOM   2049 C  CD2 . PHE A 1 263 ? -32.973 -6.746  2.252   1.00 12.54 ?  264  PHE A CD2 1 
ATOM   2050 C  CE1 . PHE A 1 263 ? -35.231 -8.176  1.543   1.00 19.21 ?  264  PHE A CE1 1 
ATOM   2051 C  CE2 . PHE A 1 263 ? -32.854 -8.053  1.795   1.00 13.36 ?  264  PHE A CE2 1 
ATOM   2052 C  CZ  . PHE A 1 263 ? -33.990 -8.767  1.447   1.00 16.06 ?  264  PHE A CZ  1 
ATOM   2053 N  N   . VAL A 1 264 ? -32.466 -5.045  5.355   1.00 10.04 ?  265  VAL A N   1 
ATOM   2054 C  CA  . VAL A 1 264 ? -31.420 -5.902  5.894   1.00 10.41 ?  265  VAL A CA  1 
ATOM   2055 C  C   . VAL A 1 264 ? -31.802 -6.303  7.319   1.00 11.46 ?  265  VAL A C   1 
ATOM   2056 O  O   . VAL A 1 264 ? -31.446 -7.395  7.778   1.00 10.71 ?  265  VAL A O   1 
ATOM   2057 C  CB  . VAL A 1 264 ? -30.025 -5.233  5.852   1.00 11.71 ?  265  VAL A CB  1 
ATOM   2058 C  CG1 . VAL A 1 264 ? -29.928 -4.057  6.788   1.00 16.83 ?  265  VAL A CG1 1 
ATOM   2059 C  CG2 . VAL A 1 264 ? -28.894 -6.241  5.970   1.00 21.07 ?  265  VAL A CG2 1 
ATOM   2060 N  N   . GLU A 1 265 ? -32.568 -5.454  8.021   1.00 11.44 ?  266  GLU A N   1 
ATOM   2061 C  CA  . GLU A 1 265 ? -32.993 -5.777  9.381   1.00 11.33 ?  266  GLU A CA  1 
ATOM   2062 C  C   . GLU A 1 265 ? -33.934 -6.978  9.426   1.00 13.71 ?  266  GLU A C   1 
ATOM   2063 O  O   . GLU A 1 265 ? -34.036 -7.634  10.470  1.00 16.94 ?  266  GLU A O   1 
ATOM   2064 C  CB  . GLU A 1 265 ? -33.658 -4.561  10.023  1.00 12.50 ?  266  GLU A CB  1 
ATOM   2065 C  CG  . GLU A 1 265 ? -32.642 -3.587  10.599  1.00 14.31 ?  266  GLU A CG  1 
ATOM   2066 C  CD  . GLU A 1 265 ? -33.221 -2.246  10.991  1.00 19.75 ?  266  GLU A CD  1 
ATOM   2067 O  OE1 . GLU A 1 265 ? -34.372 -1.933  10.624  1.00 20.22 ?  266  GLU A OE1 1 
ATOM   2068 O  OE2 . GLU A 1 265 ? -32.508 -1.500  11.694  1.00 19.73 -1 266  GLU A OE2 1 
ATOM   2069 N  N   . THR A 1 266 ? -34.631 -7.280  8.323   1.00 14.42 ?  267  THR A N   1 
ATOM   2070 C  CA  . THR A 1 266 ? -35.487 -8.466  8.285   1.00 13.58 ?  267  THR A CA  1 
ATOM   2071 C  C   . THR A 1 266 ? -34.709 -9.770  8.132   1.00 14.38 ?  267  THR A C   1 
ATOM   2072 O  O   . THR A 1 266 ? -35.310 -10.840 8.293   1.00 15.59 ?  267  THR A O   1 
ATOM   2073 C  CB  . THR A 1 266 ? -36.546 -8.392  7.162   1.00 12.36 ?  267  THR A CB  1 
ATOM   2074 O  OG1 . THR A 1 266 ? -35.934 -8.578  5.873   1.00 13.45 ?  267  THR A OG1 1 
ATOM   2075 C  CG2 . THR A 1 266 ? -37.328 -7.075  7.178   1.00 14.90 ?  267  THR A CG2 1 
ATOM   2076 N  N   . VAL A 1 267 ? -33.415 -9.730  7.818   1.00 11.97 ?  268  VAL A N   1 
ATOM   2077 C  CA  . VAL A 1 267 ? -32.663 -10.961 7.575   1.00 14.63 ?  268  VAL A CA  1 
ATOM   2078 C  C   . VAL A 1 267 ? -31.385 -11.079 8.392   1.00 14.34 ?  268  VAL A C   1 
ATOM   2079 O  O   . VAL A 1 267 ? -30.879 -12.202 8.570   1.00 15.00 ?  268  VAL A O   1 
ATOM   2080 C  CB  . VAL A 1 267 ? -32.358 -11.174 6.074   1.00 15.96 ?  268  VAL A CB  1 
ATOM   2081 C  CG1 . VAL A 1 267 ? -33.648 -11.357 5.275   1.00 16.84 ?  268  VAL A CG1 1 
ATOM   2082 C  CG2 . VAL A 1 267 ? -31.516 -10.035 5.530   1.00 16.05 ?  268  VAL A CG2 1 
ATOM   2083 N  N   . VAL A 1 268 ? -30.802 -9.987  8.894   1.00 14.06 ?  269  VAL A N   1 
ATOM   2084 C  CA  . VAL A 1 268 ? -29.464 -10.043 9.471   1.00 14.74 ?  269  VAL A CA  1 
ATOM   2085 C  C   . VAL A 1 268 ? -29.451 -10.501 10.926  1.00 11.15 ?  269  VAL A C   1 
ATOM   2086 O  O   . VAL A 1 268 ? -28.400 -10.934 11.418  1.00 12.08 ?  269  VAL A O   1 
ATOM   2087 C  CB  . VAL A 1 268 ? -28.762 -8.680  9.289   1.00 17.48 ?  269  VAL A CB  1 
ATOM   2088 C  CG1 . VAL A 1 268 ? -29.302 -7.640  10.253  1.00 17.71 ?  269  VAL A CG1 1 
ATOM   2089 C  CG2 . VAL A 1 268 ? -27.262 -8.815  9.423   1.00 21.06 ?  269  VAL A CG2 1 
ATOM   2090 N  N   . LYS A 1 269 ? -30.576 -10.420 11.627  1.00 12.89 ?  270  LYS A N   1 
ATOM   2091 C  CA  . LYS A 1 269 ? -30.590 -10.744 13.044  1.00 14.71 ?  270  LYS A CA  1 
ATOM   2092 C  C   . LYS A 1 269 ? -30.733 -12.241 13.280  1.00 16.29 ?  270  LYS A C   1 
ATOM   2093 O  O   . LYS A 1 269 ? -31.611 -12.900 12.712  1.00 18.26 ?  270  LYS A O   1 
ATOM   2094 C  CB  . LYS A 1 269 ? -31.649 -9.920  13.778  1.00 19.63 ?  270  LYS A CB  1 
ATOM   2095 C  CG  . LYS A 1 269 ? -31.115 -8.503  14.026  1.00 26.46 ?  270  LYS A CG  1 
ATOM   2096 C  CD  . LYS A 1 269 ? -32.027 -7.562  14.802  1.00 33.50 ?  270  LYS A CD  1 
ATOM   2097 C  CE  . LYS A 1 269 ? -33.329 -7.300  14.089  1.00 33.48 ?  270  LYS A CE  1 
ATOM   2098 N  NZ  . LYS A 1 269 ? -33.790 -5.910  14.377  1.00 40.65 ?  270  LYS A NZ  1 
ATOM   2099 N  N   . ALA A 1 270 ? -29.827 -12.781 14.086  1.00 14.23 ?  271  ALA A N   1 
ATOM   2100 C  CA  . ALA A 1 270 ? -29.836 -14.184 14.467  1.00 15.15 ?  271  ALA A CA  1 
ATOM   2101 C  C   . ALA A 1 270 ? -29.888 -14.227 15.985  1.00 20.98 ?  271  ALA A C   1 
ATOM   2102 O  O   . ALA A 1 270 ? -28.956 -13.768 16.654  1.00 17.77 ?  271  ALA A O   1 
ATOM   2103 C  CB  . ALA A 1 270 ? -28.581 -14.888 13.949  1.00 16.98 ?  271  ALA A CB  1 
ATOM   2104 N  N   . ALA A 1 271 ? -30.981 -14.754 16.526  1.00 21.99 ?  272  ALA A N   1 
ATOM   2105 C  CA  . ALA A 1 271 ? -31.231 -14.680 17.957  1.00 28.89 ?  272  ALA A CA  1 
ATOM   2106 C  C   . ALA A 1 271 ? -30.842 -15.979 18.647  1.00 28.97 ?  272  ALA A C   1 
ATOM   2107 O  O   . ALA A 1 271 ? -30.946 -17.067 18.075  1.00 34.30 ?  272  ALA A O   1 
ATOM   2108 C  CB  . ALA A 1 271 ? -32.698 -14.354 18.245  1.00 33.50 ?  272  ALA A CB  1 
ATOM   2109 N  N   . VAL A 1 272 ? -30.357 -15.841 19.876  1.00 25.27 ?  273  VAL A N   1 
ATOM   2110 C  CA  . VAL A 1 272 ? -30.165 -16.957 20.798  1.00 27.85 ?  273  VAL A CA  1 
ATOM   2111 C  C   . VAL A 1 272 ? -30.912 -16.616 22.080  1.00 24.01 ?  273  VAL A C   1 
ATOM   2112 O  O   . VAL A 1 272 ? -31.229 -15.444 22.332  1.00 23.62 ?  273  VAL A O   1 
ATOM   2113 C  CB  . VAL A 1 272 ? -28.664 -17.234 21.059  1.00 25.28 ?  273  VAL A CB  1 
ATOM   2114 C  CG1 . VAL A 1 272 ? -27.956 -17.579 19.762  1.00 30.65 ?  273  VAL A CG1 1 
ATOM   2115 C  CG2 . VAL A 1 272 ? -27.995 -16.043 21.742  1.00 23.06 ?  273  VAL A CG2 1 
ATOM   2116 N  N   . PRO A 1 273 ? -31.243 -17.617 22.903  1.00 27.26 ?  274  PRO A N   1 
ATOM   2117 C  CA  . PRO A 1 273 ? -32.001 -17.315 24.122  1.00 26.27 ?  274  PRO A CA  1 
ATOM   2118 C  C   . PRO A 1 273 ? -31.171 -16.711 25.240  1.00 26.30 ?  274  PRO A C   1 
ATOM   2119 O  O   . PRO A 1 273 ? -31.740 -16.022 26.096  1.00 26.69 ?  274  PRO A O   1 
ATOM   2120 C  CB  . PRO A 1 273 ? -32.570 -18.679 24.516  1.00 25.73 ?  274  PRO A CB  1 
ATOM   2121 C  CG  . PRO A 1 273 ? -31.472 -19.613 24.145  1.00 27.76 ?  274  PRO A CG  1 
ATOM   2122 C  CD  . PRO A 1 273 ? -30.879 -19.048 22.850  1.00 32.02 ?  274  PRO A CD  1 
ATOM   2123 N  N   . ALA A 1 274 ? -29.855 -16.922 25.251  1.00 21.84 ?  275  ALA A N   1 
ATOM   2124 C  CA  . ALA A 1 274 ? -29.009 -16.400 26.315  1.00 24.60 ?  275  ALA A CA  1 
ATOM   2125 C  C   . ALA A 1 274 ? -27.584 -16.317 25.796  1.00 20.98 ?  275  ALA A C   1 
ATOM   2126 O  O   . ALA A 1 274 ? -27.216 -17.075 24.896  1.00 19.72 ?  275  ALA A O   1 
ATOM   2127 C  CB  . ALA A 1 274 ? -29.064 -17.316 27.546  1.00 21.21 ?  275  ALA A CB  1 
ATOM   2128 N  N   . PRO A 1 275 ? -26.764 -15.418 26.332  1.00 17.59 ?  276  PRO A N   1 
ATOM   2129 C  CA  . PRO A 1 275 ? -25.351 -15.401 25.946  1.00 15.74 ?  276  PRO A CA  1 
ATOM   2130 C  C   . PRO A 1 275 ? -24.669 -16.670 26.426  1.00 17.04 ?  276  PRO A C   1 
ATOM   2131 O  O   . PRO A 1 275 ? -25.161 -17.371 27.313  1.00 16.36 ?  276  PRO A O   1 
ATOM   2132 C  CB  . PRO A 1 275 ? -24.794 -14.179 26.678  1.00 18.63 ?  276  PRO A CB  1 
ATOM   2133 C  CG  . PRO A 1 275 ? -25.740 -13.982 27.844  1.00 20.07 ?  276  PRO A CG  1 
ATOM   2134 C  CD  . PRO A 1 275 ? -27.082 -14.421 27.367  1.00 20.31 ?  276  PRO A CD  1 
ATOM   2135 N  N   . VAL A 1 276 ? -23.510 -16.955 25.829  1.00 12.59 ?  277  VAL A N   1 
ATOM   2136 C  CA  . VAL A 1 276 ? -22.783 -18.196 26.067  1.00 12.53 ?  277  VAL A CA  1 
ATOM   2137 C  C   . VAL A 1 276 ? -21.324 -17.887 26.374  1.00 12.16 ?  277  VAL A C   1 
ATOM   2138 O  O   . VAL A 1 276 ? -20.822 -16.797 26.098  1.00 11.51 ?  277  VAL A O   1 
ATOM   2139 C  CB  . VAL A 1 276 ? -22.889 -19.177 24.876  1.00 12.97 ?  277  VAL A CB  1 
ATOM   2140 C  CG1 . VAL A 1 276 ? -24.338 -19.596 24.666  1.00 13.29 ?  277  VAL A CG1 1 
ATOM   2141 C  CG2 . VAL A 1 276 ? -22.307 -18.554 23.595  1.00 13.12 ?  277  VAL A CG2 1 
ATOM   2142 N  N   . ASP A 1 277 ? -20.631 -18.873 26.943  1.00 11.12 ?  278  ASP A N   1 
ATOM   2143 C  CA  . ASP A 1 277 ? -19.254 -18.634 27.361  1.00 11.17 ?  278  ASP A CA  1 
ATOM   2144 C  C   . ASP A 1 277 ? -18.262 -18.663 26.206  1.00 10.58 ?  278  ASP A C   1 
ATOM   2145 O  O   . ASP A 1 277 ? -17.166 -18.110 26.340  1.00 11.23 ?  278  ASP A O   1 
ATOM   2146 C  CB  . ASP A 1 277 ? -18.809 -19.631 28.440  1.00 12.96 ?  278  ASP A CB  1 
ATOM   2147 C  CG  . ASP A 1 277 ? -19.510 -19.410 29.758  1.00 23.58 ?  278  ASP A CG  1 
ATOM   2148 O  OD1 . ASP A 1 277 ? -20.376 -20.239 30.134  1.00 24.14 ?  278  ASP A OD1 1 
ATOM   2149 O  OD2 . ASP A 1 277 ? -19.242 -18.361 30.380  1.00 19.98 -1 278  ASP A OD2 1 
ATOM   2150 N  N   . VAL A 1 278 ? -18.586 -19.324 25.096  1.00 9.18  ?  279  VAL A N   1 
ATOM   2151 C  CA  . VAL A 1 278 ? -17.653 -19.483 23.979  1.00 10.05 ?  279  VAL A CA  1 
ATOM   2152 C  C   . VAL A 1 278 ? -18.383 -19.139 22.687  1.00 9.24  ?  279  VAL A C   1 
ATOM   2153 O  O   . VAL A 1 278 ? -19.404 -19.755 22.365  1.00 10.90 ?  279  VAL A O   1 
ATOM   2154 C  CB  . VAL A 1 278 ? -17.076 -20.906 23.906  1.00 10.89 ?  279  VAL A CB  1 
ATOM   2155 C  CG1 . VAL A 1 278 ? -16.044 -21.008 22.787  1.00 11.13 ?  279  VAL A CG1 1 
ATOM   2156 C  CG2 . VAL A 1 278 ? -16.463 -21.312 25.244  1.00 12.30 ?  279  VAL A CG2 1 
ATOM   2157 N  N   . VAL A 1 279 ? -17.868 -18.157 21.942  1.00 8.19  ?  280  VAL A N   1 
ATOM   2158 C  CA  . VAL A 1 279 ? -18.443 -17.793 20.652  1.00 8.93  ?  280  VAL A CA  1 
ATOM   2159 C  C   . VAL A 1 279 ? -17.370 -17.972 19.588  1.00 8.73  ?  280  VAL A C   1 
ATOM   2160 O  O   . VAL A 1 279 ? -16.291 -17.378 19.692  1.00 10.01 ?  280  VAL A O   1 
ATOM   2161 C  CB  . VAL A 1 279 ? -18.985 -16.355 20.648  1.00 10.15 ?  280  VAL A CB  1 
ATOM   2162 C  CG1 . VAL A 1 279 ? -19.520 -16.001 19.266  1.00 9.35  ?  280  VAL A CG1 1 
ATOM   2163 C  CG2 . VAL A 1 279 ? -20.067 -16.182 21.697  1.00 11.94 ?  280  VAL A CG2 1 
ATOM   2164 N  N   . VAL A 1 280 ? -17.661 -18.789 18.576  1.00 8.64  ?  281  VAL A N   1 
ATOM   2165 C  CA  . VAL A 1 280 ? -16.761 -19.010 17.449  1.00 9.22  ?  281  VAL A CA  1 
ATOM   2166 C  C   . VAL A 1 280 ? -17.237 -18.135 16.306  1.00 8.27  ?  281  VAL A C   1 
ATOM   2167 O  O   . VAL A 1 280 ? -18.426 -18.152 15.962  1.00 9.58  ?  281  VAL A O   1 
ATOM   2168 C  CB  . VAL A 1 280 ? -16.751 -20.487 17.023  1.00 8.00  ?  281  VAL A CB  1 
ATOM   2169 C  CG1 . VAL A 1 280 ? -15.910 -20.673 15.751  1.00 9.82  ?  281  VAL A CG1 1 
ATOM   2170 C  CG2 . VAL A 1 280 ? -16.239 -21.351 18.157  1.00 9.72  ?  281  VAL A CG2 1 
ATOM   2171 N  N   . THR A 1 281 ? -16.318 -17.382 15.707  1.00 8.16  ?  282  THR A N   1 
ATOM   2172 C  CA  . THR A 1 281 ? -16.700 -16.462 14.650  1.00 7.63  ?  282  THR A CA  1 
ATOM   2173 C  C   . THR A 1 281 ? -15.601 -16.334 13.602  1.00 8.09  ?  282  THR A C   1 
ATOM   2174 O  O   . THR A 1 281 ? -14.561 -16.991 13.659  1.00 8.04  ?  282  THR A O   1 
ATOM   2175 C  CB  . THR A 1 281 ? -17.156 -15.119 15.228  1.00 9.17  ?  282  THR A CB  1 
ATOM   2176 O  OG1 . THR A 1 281 ? -17.857 -14.401 14.209  1.00 9.41  ?  282  THR A OG1 1 
ATOM   2177 C  CG2 . THR A 1 281 ? -15.984 -14.310 15.753  1.00 9.51  ?  282  THR A CG2 1 
ATOM   2178 N  N   . SER A 1 282 ? -15.863 -15.484 12.616  1.00 8.62  ?  283  SER A N   1 
ATOM   2179 C  CA  . SER A 1 282 ? -14.942 -15.226 11.521  1.00 6.97  ?  283  SER A CA  1 
ATOM   2180 C  C   . SER A 1 282 ? -14.866 -13.725 11.305  1.00 8.06  ?  283  SER A C   1 
ATOM   2181 O  O   . SER A 1 282 ? -15.524 -12.936 11.994  1.00 8.08  ?  283  SER A O   1 
ATOM   2182 C  CB  . SER A 1 282 ? -15.437 -15.888 10.232  1.00 7.39  ?  283  SER A CB  1 
ATOM   2183 O  OG  . SER A 1 282 ? -16.539 -15.158 9.685   1.00 8.31  ?  283  SER A OG  1 
ATOM   2184 N  N   . SER A 1 283 ? -14.060 -13.326 10.319  1.00 7.22  ?  284  SER A N   1 
ATOM   2185 C  CA  . SER A 1 283 ? -14.019 -11.950 9.842   1.00 6.75  ?  284  SER A CA  1 
ATOM   2186 C  C   . SER A 1 283 ? -14.638 -11.836 8.449   1.00 7.64  ?  284  SER A C   1 
ATOM   2187 O  O   . SER A 1 283 ? -14.244 -10.977 7.652   1.00 7.88  ?  284  SER A O   1 
ATOM   2188 C  CB  . SER A 1 283 ? -12.586 -11.425 9.863   1.00 9.20  ?  284  SER A CB  1 
ATOM   2189 O  OG  . SER A 1 283 ? -12.530 -10.069 9.432   1.00 9.89  ?  284  SER A OG  1 
ATOM   2190 N  N   . ALA A 1 284 ? -15.584 -12.724 8.126   1.00 7.72  ?  285  ALA A N   1 
ATOM   2191 C  CA  . ALA A 1 284 ? -16.349 -12.678 6.880   1.00 7.94  ?  285  ALA A CA  1 
ATOM   2192 C  C   . ALA A 1 284 ? -15.513 -12.973 5.632   1.00 8.40  ?  285  ALA A C   1 
ATOM   2193 O  O   . ALA A 1 284 ? -15.932 -12.666 4.510   1.00 8.83  ?  285  ALA A O   1 
ATOM   2194 C  CB  . ALA A 1 284 ? -17.172 -11.388 6.738   1.00 8.39  ?  285  ALA A CB  1 
ATOM   2195 N  N   . GLY A 1 285 ? -14.346 -13.592 5.797   1.00 7.46  ?  286  GLY A N   1 
ATOM   2196 C  CA  . GLY A 1 285 ? -13.558 -14.044 4.664   1.00 6.63  ?  286  GLY A CA  1 
ATOM   2197 C  C   . GLY A 1 285 ? -13.064 -12.883 3.805   1.00 7.64  ?  286  GLY A C   1 
ATOM   2198 O  O   . GLY A 1 285 ? -13.109 -11.703 4.177   1.00 8.17  ?  286  GLY A O   1 
ATOM   2199 N  N   . HIS A 1 286 ? -12.604 -13.248 2.617   1.00 7.49  ?  287  HIS A N   1 
ATOM   2200 C  CA  . HIS A 1 286 ? -12.152 -12.244 1.669   1.00 7.88  ?  287  HIS A CA  1 
ATOM   2201 C  C   . HIS A 1 286 ? -13.358 -11.460 1.159   1.00 8.50  ?  287  HIS A C   1 
ATOM   2202 O  O   . HIS A 1 286 ? -14.404 -12.045 0.869   1.00 9.17  ?  287  HIS A O   1 
ATOM   2203 C  CB  . HIS A 1 286 ? -11.448 -12.945 0.504   1.00 9.93  ?  287  HIS A CB  1 
ATOM   2204 C  CG  . HIS A 1 286 ? -10.918 -12.009 -0.536  1.00 8.70  ?  287  HIS A CG  1 
ATOM   2205 N  ND1 . HIS A 1 286 ? -9.645  -11.484 -0.477  1.00 12.81 ?  287  HIS A ND1 1 
ATOM   2206 C  CD2 . HIS A 1 286 ? -11.495 -11.486 -1.643  1.00 10.19 ?  287  HIS A CD2 1 
ATOM   2207 C  CE1 . HIS A 1 286 ? -9.458  -10.679 -1.512  1.00 11.36 ?  287  HIS A CE1 1 
ATOM   2208 N  NE2 . HIS A 1 286 ? -10.563 -10.664 -2.233  1.00 13.60 ?  287  HIS A NE2 1 
ATOM   2209 N  N   . PRO A 1 287 ? -13.251 -10.131 1.033   1.00 7.89  ?  288  PRO A N   1 
ATOM   2210 C  CA  . PRO A 1 287 ? -12.051 -9.305  1.203   1.00 7.62  ?  288  PRO A CA  1 
ATOM   2211 C  C   . PRO A 1 287 ? -11.900 -8.651  2.570   1.00 8.06  ?  288  PRO A C   1 
ATOM   2212 O  O   . PRO A 1 287 ? -10.876 -8.004  2.823   1.00 9.48  ?  288  PRO A O   1 
ATOM   2213 C  CB  . PRO A 1 287 ? -12.268 -8.208  0.166   1.00 8.55  ?  288  PRO A CB  1 
ATOM   2214 C  CG  . PRO A 1 287 ? -13.780 -7.996  0.200   1.00 8.47  ?  288  PRO A CG  1 
ATOM   2215 C  CD  . PRO A 1 287 ? -14.360 -9.384  0.405   1.00 8.31  ?  288  PRO A CD  1 
ATOM   2216 N  N   . LEU A 1 288 ? -12.876 -8.821  3.459   1.00 6.91  ?  289  LEU A N   1 
ATOM   2217 C  CA  . LEU A 1 288 ? -12.804 -8.103  4.726   1.00 7.72  ?  289  LEU A CA  1 
ATOM   2218 C  C   . LEU A 1 288 ? -11.647 -8.596  5.586   1.00 7.74  ?  289  LEU A C   1 
ATOM   2219 O  O   . LEU A 1 288 ? -10.993 -7.794  6.260   1.00 8.42  ?  289  LEU A O   1 
ATOM   2220 C  CB  . LEU A 1 288 ? -14.129 -8.191  5.479   1.00 8.71  ?  289  LEU A CB  1 
ATOM   2221 C  CG  . LEU A 1 288 ? -14.192 -7.368  6.766   1.00 7.07  ?  289  LEU A CG  1 
ATOM   2222 C  CD1 . LEU A 1 288 ? -13.983 -5.863  6.493   1.00 8.74  ?  289  LEU A CD1 1 
ATOM   2223 C  CD2 . LEU A 1 288 ? -15.495 -7.630  7.518   1.00 9.22  ?  289  LEU A CD2 1 
ATOM   2224 N  N   . ASP A 1 289 ? -11.354 -9.907  5.560   1.00 7.46  ?  290  ASP A N   1 
ATOM   2225 C  CA  . ASP A 1 289 ? -10.404 -10.477 6.518   1.00 8.15  ?  290  ASP A CA  1 
ATOM   2226 C  C   . ASP A 1 289 ? -8.933  -10.335 6.104   1.00 8.81  ?  290  ASP A C   1 
ATOM   2227 O  O   . ASP A 1 289 ? -8.073  -11.031 6.662   1.00 8.40  ?  290  ASP A O   1 
ATOM   2228 C  CB  . ASP A 1 289 ? -10.801 -11.912 6.919   1.00 8.61  ?  290  ASP A CB  1 
ATOM   2229 C  CG  . ASP A 1 289 ? -10.360 -13.002 5.932   1.00 9.98  ?  290  ASP A CG  1 
ATOM   2230 O  OD1 . ASP A 1 289 ? -9.904  -12.726 4.798   1.00 8.51  ?  290  ASP A OD1 1 
ATOM   2231 O  OD2 . ASP A 1 289 ? -10.516 -14.195 6.311   1.00 8.71  -1 290  ASP A OD2 1 
ATOM   2232 N  N   . LEU A 1 290 ? -8.630  -9.395  5.195   1.00 8.71  ?  291  LEU A N   1 
ATOM   2233 C  CA  . LEU A 1 290 ? -7.252  -9.173  4.765   1.00 8.06  ?  291  LEU A CA  1 
ATOM   2234 C  C   . LEU A 1 290 ? -6.339  -8.741  5.910   1.00 8.05  ?  291  LEU A C   1 
ATOM   2235 O  O   . LEU A 1 290 ? -5.142  -9.050  5.886   1.00 7.59  ?  291  LEU A O   1 
ATOM   2236 C  CB  . LEU A 1 290 ? -7.222  -8.084  3.694   1.00 8.91  ?  291  LEU A CB  1 
ATOM   2237 C  CG  . LEU A 1 290 ? -7.713  -8.454  2.302   1.00 8.59  ?  291  LEU A CG  1 
ATOM   2238 C  CD1 . LEU A 1 290 ? -7.792  -7.201  1.467   1.00 11.17 ?  291  LEU A CD1 1 
ATOM   2239 C  CD2 . LEU A 1 290 ? -6.776  -9.451  1.660   1.00 9.39  ?  291  LEU A CD2 1 
ATOM   2240 N  N   . THR A 1 291 ? -6.845  -7.979  6.894   1.00 7.21  ?  292  THR A N   1 
ATOM   2241 C  CA  . THR A 1 291 ? -5.976  -7.445  7.934   1.00 7.52  ?  292  THR A CA  1 
ATOM   2242 C  C   . THR A 1 291 ? -6.561  -7.659  9.322   1.00 9.25  ?  292  THR A C   1 
ATOM   2243 O  O   . THR A 1 291 ? -7.781  -7.738  9.503   1.00 7.57  ?  292  THR A O   1 
ATOM   2244 C  CB  . THR A 1 291 ? -5.695  -5.944  7.758   1.00 8.17  ?  292  THR A CB  1 
ATOM   2245 O  OG1 . THR A 1 291 ? -6.934  -5.224  7.800   1.00 9.26  ?  292  THR A OG1 1 
ATOM   2246 C  CG2 . THR A 1 291 ? -4.944  -5.675  6.469   1.00 8.43  ?  292  THR A CG2 1 
ATOM   2247 N  N   . PHE A 1 292 ? -5.659  -7.713  10.312  1.00 7.55  ?  293  PHE A N   1 
ATOM   2248 C  CA  . PHE A 1 292 ? -6.092  -7.777  11.706  1.00 7.51  ?  293  PHE A CA  1 
ATOM   2249 C  C   . PHE A 1 292 ? -6.949  -6.562  12.052  1.00 7.56  ?  293  PHE A C   1 
ATOM   2250 O  O   . PHE A 1 292 ? -7.960  -6.689  12.759  1.00 7.72  ?  293  PHE A O   1 
ATOM   2251 C  CB  . PHE A 1 292 ? -4.866  -7.869  12.627  1.00 8.04  ?  293  PHE A CB  1 
ATOM   2252 C  CG  . PHE A 1 292 ? -5.200  -7.964  14.095  1.00 7.89  ?  293  PHE A CG  1 
ATOM   2253 C  CD1 . PHE A 1 292 ? -5.437  -9.198  14.675  1.00 9.57  ?  293  PHE A CD1 1 
ATOM   2254 C  CD2 . PHE A 1 292 ? -5.267  -6.833  14.896  1.00 9.16  ?  293  PHE A CD2 1 
ATOM   2255 C  CE1 . PHE A 1 292 ? -5.745  -9.306  16.009  1.00 11.45 ?  293  PHE A CE1 1 
ATOM   2256 C  CE2 . PHE A 1 292 ? -5.582  -6.936  16.250  1.00 11.25 ?  293  PHE A CE2 1 
ATOM   2257 C  CZ  . PHE A 1 292 ? -5.803  -8.171  16.799  1.00 9.45  ?  293  PHE A CZ  1 
ATOM   2258 N  N   . TYR A 1 293 ? -6.568  -5.382  11.541  1.00 7.45  ?  294  TYR A N   1 
ATOM   2259 C  CA  . TYR A 1 293 ? -7.360  -4.170  11.726  1.00 7.24  ?  294  TYR A CA  1 
ATOM   2260 C  C   . TYR A 1 293 ? -8.835  -4.413  11.411  1.00 7.96  ?  294  TYR A C   1 
ATOM   2261 O  O   . TYR A 1 293 ? -9.715  -4.088  12.214  1.00 8.50  ?  294  TYR A O   1 
ATOM   2262 C  CB  . TYR A 1 293 ? -6.759  -3.077  10.833  1.00 8.28  ?  294  TYR A CB  1 
ATOM   2263 C  CG  . TYR A 1 293 ? -7.542  -1.789  10.709  1.00 9.90  ?  294  TYR A CG  1 
ATOM   2264 C  CD1 . TYR A 1 293 ? -8.350  -1.569  9.605   1.00 11.97 ?  294  TYR A CD1 1 
ATOM   2265 C  CD2 . TYR A 1 293 ? -7.423  -0.769  11.644  1.00 8.79  ?  294  TYR A CD2 1 
ATOM   2266 C  CE1 . TYR A 1 293 ? -9.042  -0.382  9.449   1.00 11.83 ?  294  TYR A CE1 1 
ATOM   2267 C  CE2 . TYR A 1 293 ? -8.116  0.415   11.496  1.00 9.53  ?  294  TYR A CE2 1 
ATOM   2268 C  CZ  . TYR A 1 293 ? -8.930  0.595   10.407  1.00 9.62  ?  294  TYR A CZ  1 
ATOM   2269 O  OH  . TYR A 1 293 ? -9.615  1.787   10.267  1.00 12.72 ?  294  TYR A OH  1 
ATOM   2270 N  N   . GLN A 1 294 ? -9.129  -5.009  10.258  1.00 8.04  ?  295  GLN A N   1 
ATOM   2271 C  CA  . GLN A 1 294 ? -10.529 -5.258  9.922   1.00 8.10  ?  295  GLN A CA  1 
ATOM   2272 C  C   . GLN A 1 294 ? -11.112 -6.420  10.722  1.00 8.77  ?  295  GLN A C   1 
ATOM   2273 O  O   . GLN A 1 294 ? -12.301 -6.398  11.063  1.00 8.53  ?  295  GLN A O   1 
ATOM   2274 C  CB  . GLN A 1 294 ? -10.683 -5.539  8.425   1.00 8.69  ?  295  GLN A CB  1 
ATOM   2275 C  CG  . GLN A 1 294 ? -10.383 -4.349  7.527   1.00 7.40  ?  295  GLN A CG  1 
ATOM   2276 C  CD  . GLN A 1 294 ? -11.410 -3.229  7.654   1.00 7.97  ?  295  GLN A CD  1 
ATOM   2277 O  OE1 . GLN A 1 294 ? -12.483 -3.392  8.257   1.00 9.12  ?  295  GLN A OE1 1 
ATOM   2278 N  NE2 . GLN A 1 294 ? -11.086 -2.082  7.072   1.00 8.71  ?  295  GLN A NE2 1 
ATOM   2279 N  N   . ALA A 1 295 ? -10.298 -7.433  11.036  1.00 6.92  ?  296  ALA A N   1 
ATOM   2280 C  CA  . ALA A 1 295 ? -10.808 -8.614  11.725  1.00 7.59  ?  296  ALA A CA  1 
ATOM   2281 C  C   . ALA A 1 295 ? -11.313 -8.301  13.127  1.00 7.48  ?  296  ALA A C   1 
ATOM   2282 O  O   . ALA A 1 295 ? -12.101 -9.075  13.678  1.00 8.12  ?  296  ALA A O   1 
ATOM   2283 C  CB  . ALA A 1 295 ? -9.745  -9.708  11.753  1.00 9.61  ?  296  ALA A CB  1 
ATOM   2284 N  N   . VAL A 1 296 ? -10.913 -7.165  13.704  1.00 7.33  ?  297  VAL A N   1 
ATOM   2285 C  CA  . VAL A 1 296 ? -11.518 -6.726  14.956  1.00 8.98  ?  297  VAL A CA  1 
ATOM   2286 C  C   . VAL A 1 296 ? -13.042 -6.677  14.845  1.00 7.57  ?  297  VAL A C   1 
ATOM   2287 O  O   . VAL A 1 296 ? -13.753 -6.892  15.837  1.00 8.73  ?  297  VAL A O   1 
ATOM   2288 C  CB  . VAL A 1 296 ? -10.902 -5.377  15.378  1.00 8.36  ?  297  VAL A CB  1 
ATOM   2289 C  CG1 . VAL A 1 296 ? -11.687 -4.737  16.525  1.00 11.17 ?  297  VAL A CG1 1 
ATOM   2290 C  CG2 . VAL A 1 296 ? -9.446  -5.568  15.749  1.00 10.06 ?  297  VAL A CG2 1 
ATOM   2291 N  N   . LYS A 1 297 ? -13.572 -6.433  13.642  1.00 7.14  ?  298  LYS A N   1 
ATOM   2292 C  CA  . LYS A 1 297 ? -15.021 -6.426  13.441  1.00 7.91  ?  298  LYS A CA  1 
ATOM   2293 C  C   . LYS A 1 297 ? -15.670 -7.763  13.801  1.00 7.06  ?  298  LYS A C   1 
ATOM   2294 O  O   . LYS A 1 297 ? -16.824 -7.783  14.248  1.00 8.53  ?  298  LYS A O   1 
ATOM   2295 C  CB  . LYS A 1 297 ? -15.331 -6.104  11.987  1.00 7.29  ?  298  LYS A CB  1 
ATOM   2296 C  CG  . LYS A 1 297 ? -14.948 -4.698  11.618  1.00 6.77  ?  298  LYS A CG  1 
ATOM   2297 C  CD  . LYS A 1 297 ? -15.168 -4.450  10.138  1.00 7.31  ?  298  LYS A CD  1 
ATOM   2298 C  CE  . LYS A 1 297 ? -15.359 -2.969  9.858   1.00 6.72  ?  298  LYS A CE  1 
ATOM   2299 N  NZ  . LYS A 1 297 ? -15.172 -2.666  8.383   1.00 7.55  ?  298  LYS A NZ  1 
ATOM   2300 N  N   . GLY A 1 298 ? -14.989 -8.894  13.576  1.00 6.85  ?  299  GLY A N   1 
ATOM   2301 C  CA  . GLY A 1 298 ? -15.574 -10.162 14.004  1.00 7.14  ?  299  GLY A CA  1 
ATOM   2302 C  C   . GLY A 1 298 ? -15.671 -10.245 15.514  1.00 7.89  ?  299  GLY A C   1 
ATOM   2303 O  O   . GLY A 1 298 ? -16.627 -10.801 16.064  1.00 8.23  ?  299  GLY A O   1 
ATOM   2304 N  N   . LEU A 1 299 ? -14.693 -9.657  16.204  1.00 7.49  ?  300  LEU A N   1 
ATOM   2305 C  CA  . LEU A 1 299 ? -14.690 -9.663  17.660  1.00 7.92  ?  300  LEU A CA  1 
ATOM   2306 C  C   . LEU A 1 299 ? -15.803 -8.781  18.219  1.00 9.12  ?  300  LEU A C   1 
ATOM   2307 O  O   . LEU A 1 299 ? -16.545 -9.198  19.117  1.00 9.59  ?  300  LEU A O   1 
ATOM   2308 C  CB  . LEU A 1 299 ? -13.319 -9.212  18.159  1.00 8.27  ?  300  LEU A CB  1 
ATOM   2309 C  CG  . LEU A 1 299 ? -12.173 -10.089 17.652  1.00 6.80  ?  300  LEU A CG  1 
ATOM   2310 C  CD1 . LEU A 1 299 ? -10.849 -9.531  18.160  1.00 9.40  ?  300  LEU A CD1 1 
ATOM   2311 C  CD2 . LEU A 1 299 ? -12.344 -11.534 18.101  1.00 8.85  ?  300  LEU A CD2 1 
ATOM   2312 N  N   . THR A 1 300 ? -15.935 -7.544  17.722  1.00 7.63  ?  301  THR A N   1 
ATOM   2313 C  CA  . THR A 1 300 ? -17.022 -6.700  18.223  1.00 9.72  ?  301  THR A CA  1 
ATOM   2314 C  C   . THR A 1 300 ? -18.379 -7.290  17.861  1.00 9.72  ?  301  THR A C   1 
ATOM   2315 O  O   . THR A 1 300 ? -19.342 -7.187  18.633  1.00 10.18 ?  301  THR A O   1 
ATOM   2316 C  CB  . THR A 1 300 ? -16.916 -5.266  17.694  1.00 9.67  ?  301  THR A CB  1 
ATOM   2317 O  OG1 . THR A 1 300 ? -16.798 -5.262  16.262  1.00 9.90  ?  301  THR A OG1 1 
ATOM   2318 C  CG2 . THR A 1 300 ? -15.731 -4.556  18.306  1.00 11.25 ?  301  THR A CG2 1 
ATOM   2319 N  N   . GLY A 1 301 ? -18.471 -7.919  16.688  1.00 9.09  ?  302  GLY A N   1 
ATOM   2320 C  CA  . GLY A 1 301 ? -19.739 -8.482  16.263  1.00 9.91  ?  302  GLY A CA  1 
ATOM   2321 C  C   . GLY A 1 301 ? -20.245 -9.574  17.189  1.00 9.95  ?  302  GLY A C   1 
ATOM   2322 O  O   . GLY A 1 301 ? -21.453 -9.757  17.332  1.00 11.11 ?  302  GLY A O   1 
ATOM   2323 N  N   . ALA A 1 302 ? -19.329 -10.298 17.848  1.00 9.36  ?  303  ALA A N   1 
ATOM   2324 C  CA  . ALA A 1 302 ? -19.711 -11.403 18.725  1.00 9.23  ?  303  ALA A CA  1 
ATOM   2325 C  C   . ALA A 1 302 ? -20.139 -10.945 20.114  1.00 11.63 ?  303  ALA A C   1 
ATOM   2326 O  O   . ALA A 1 302 ? -20.775 -11.720 20.838  1.00 11.13 ?  303  ALA A O   1 
ATOM   2327 C  CB  . ALA A 1 302 ? -18.533 -12.359 18.876  1.00 11.15 ?  303  ALA A CB  1 
ATOM   2328 N  N   . LEU A 1 303 ? -19.803 -9.714  20.501  1.00 9.28  ?  304  LEU A N   1 
ATOM   2329 C  CA  . LEU A 1 303 ? -20.007 -9.263  21.878  1.00 10.57 ?  304  LEU A CA  1 
ATOM   2330 C  C   . LEU A 1 303 ? -21.425 -9.421  22.414  1.00 12.38 ?  304  LEU A C   1 
ATOM   2331 O  O   . LEU A 1 303 ? -21.564 -9.780  23.598  1.00 12.02 ?  304  LEU A O   1 
ATOM   2332 C  CB  . LEU A 1 303 ? -19.535 -7.809  22.043  1.00 10.91 ?  304  LEU A CB  1 
ATOM   2333 C  CG  . LEU A 1 303 ? -18.024 -7.577  21.999  1.00 11.30 ?  304  LEU A CG  1 
ATOM   2334 C  CD1 . LEU A 1 303 ? -17.754 -6.084  22.085  1.00 15.36 ?  304  LEU A CD1 1 
ATOM   2335 C  CD2 . LEU A 1 303 ? -17.285 -8.311  23.122  1.00 11.99 ?  304  LEU A CD2 1 
ATOM   2336 N  N   . PRO A 1 304 ? -22.497 -9.155  21.660  1.00 11.27 ?  305  PRO A N   1 
ATOM   2337 C  CA  . PRO A 1 304 ? -23.832 -9.258  22.271  1.00 12.77 ?  305  PRO A CA  1 
ATOM   2338 C  C   . PRO A 1 304 ? -24.152 -10.638 22.821  1.00 14.05 ?  305  PRO A C   1 
ATOM   2339 O  O   . PRO A 1 304 ? -25.007 -10.748 23.707  1.00 15.08 ?  305  PRO A O   1 
ATOM   2340 C  CB  . PRO A 1 304 ? -24.775 -8.883  21.119  1.00 12.93 ?  305  PRO A CB  1 
ATOM   2341 C  CG  . PRO A 1 304 ? -23.971 -8.000  20.263  1.00 14.19 ?  305  PRO A CG  1 
ATOM   2342 C  CD  . PRO A 1 304 ? -22.584 -8.577  20.301  1.00 11.37 ?  305  PRO A CD  1 
ATOM   2343 N  N   . ILE A 1 305 ? -23.512 -11.699 22.331  1.00 9.89  ?  306  ILE A N   1 
ATOM   2344 C  CA  . ILE A 1 305 ? -23.895 -13.047 22.739  1.00 11.11 ?  306  ILE A CA  1 
ATOM   2345 C  C   . ILE A 1 305 ? -22.814 -13.754 23.546  1.00 11.84 ?  306  ILE A C   1 
ATOM   2346 O  O   . ILE A 1 305 ? -22.967 -14.937 23.855  1.00 11.74 ?  306  ILE A O   1 
ATOM   2347 C  CB  . ILE A 1 305 ? -24.399 -13.924 21.581  1.00 9.71  ?  306  ILE A CB  1 
ATOM   2348 C  CG1 . ILE A 1 305 ? -23.327 -14.153 20.507  1.00 11.56 ?  306  ILE A CG1 1 
ATOM   2349 C  CG2 . ILE A 1 305 ? -25.656 -13.322 20.964  1.00 11.32 ?  306  ILE A CG2 1 
ATOM   2350 C  CD1 . ILE A 1 305 ? -23.563 -15.420 19.700  1.00 13.03 ?  306  ILE A CD1 1 
ATOM   2351 N  N   . VAL A 1 306 ? -21.730 -13.078 23.904  1.00 9.80  ?  307  VAL A N   1 
ATOM   2352 C  CA  . VAL A 1 306 ? -20.731 -13.677 24.783  1.00 11.14 ?  307  VAL A CA  1 
ATOM   2353 C  C   . VAL A 1 306 ? -21.001 -13.234 26.216  1.00 12.78 ?  307  VAL A C   1 
ATOM   2354 O  O   . VAL A 1 306 ? -21.357 -12.077 26.470  1.00 11.71 ?  307  VAL A O   1 
ATOM   2355 C  CB  . VAL A 1 306 ? -19.281 -13.383 24.339  1.00 10.08 ?  307  VAL A CB  1 
ATOM   2356 C  CG1 . VAL A 1 306 ? -18.909 -11.918 24.571  1.00 11.83 ?  307  VAL A CG1 1 
ATOM   2357 C  CG2 . VAL A 1 306 ? -18.297 -14.316 25.059  1.00 12.43 ?  307  VAL A CG2 1 
ATOM   2358 N  N   . LYS A 1 307 ? -20.864 -14.162 27.158  1.00 11.17 ?  308  LYS A N   1 
ATOM   2359 C  CA  . LYS A 1 307 ? -21.009 -13.799 28.559  1.00 12.93 ?  308  LYS A CA  1 
ATOM   2360 C  C   . LYS A 1 307 ? -19.786 -13.001 29.003  1.00 11.58 ?  308  LYS A C   1 
ATOM   2361 O  O   . LYS A 1 307 ? -18.689 -13.200 28.480  1.00 11.94 ?  308  LYS A O   1 
ATOM   2362 C  CB  . LYS A 1 307 ? -21.129 -15.066 29.401  1.00 13.92 ?  308  LYS A CB  1 
ATOM   2363 C  CG  . LYS A 1 307 ? -22.460 -15.758 29.213  1.00 17.74 ?  308  LYS A CG  1 
ATOM   2364 C  CD  . LYS A 1 307 ? -22.479 -17.178 29.772  1.00 19.82 ?  308  LYS A CD  1 
ATOM   2365 C  CE  . LYS A 1 307 ? -22.809 -17.221 31.247  1.00 25.09 ?  308  LYS A CE  1 
ATOM   2366 N  NZ  . LYS A 1 307 ? -22.821 -18.640 31.727  1.00 21.78 ?  308  LYS A NZ  1 
ATOM   2367 N  N   . PRO A 1 308 ? -19.948 -12.069 29.946  1.00 14.08 ?  309  PRO A N   1 
ATOM   2368 C  CA  . PRO A 1 308 ? -18.776 -11.402 30.519  1.00 12.00 ?  309  PRO A CA  1 
ATOM   2369 C  C   . PRO A 1 308 ? -17.773 -12.436 31.008  1.00 11.80 ?  309  PRO A C   1 
ATOM   2370 O  O   . PRO A 1 308 ? -18.135 -13.426 31.651  1.00 12.83 ?  309  PRO A O   1 
ATOM   2371 C  CB  . PRO A 1 308 ? -19.369 -10.595 31.677  1.00 15.05 ?  309  PRO A CB  1 
ATOM   2372 C  CG  . PRO A 1 308 ? -20.752 -10.287 31.204  1.00 17.95 ?  309  PRO A CG  1 
ATOM   2373 C  CD  . PRO A 1 308 ? -21.199 -11.556 30.531  1.00 17.99 ?  309  PRO A CD  1 
ATOM   2374 N  N   . GLY A 1 309 ? -16.511 -12.225 30.662  1.00 11.28 ?  310  GLY A N   1 
ATOM   2375 C  CA  . GLY A 1 309 ? -15.462 -13.154 30.973  1.00 10.55 ?  310  GLY A CA  1 
ATOM   2376 C  C   . GLY A 1 309 ? -15.370 -14.347 30.052  1.00 10.87 ?  310  GLY A C   1 
ATOM   2377 O  O   . GLY A 1 309 ? -14.486 -15.188 30.261  1.00 11.10 ?  310  GLY A O   1 
ATOM   2378 N  N   . GLY A 1 310 ? -16.248 -14.445 29.051  1.00 10.54 ?  311  GLY A N   1 
ATOM   2379 C  CA  . GLY A 1 310 ? -16.216 -15.518 28.078  1.00 10.29 ?  311  GLY A CA  1 
ATOM   2380 C  C   . GLY A 1 310 ? -15.058 -15.375 27.108  1.00 9.48  ?  311  GLY A C   1 
ATOM   2381 O  O   . GLY A 1 310 ? -14.179 -14.524 27.247  1.00 9.19  ?  311  GLY A O   1 
ATOM   2382 N  N   . THR A 1 311 ? -15.058 -16.259 26.107  1.00 9.18  ?  312  THR A N   1 
ATOM   2383 C  CA  . THR A 1 311 ? -14.003 -16.298 25.100  1.00 8.17  ?  312  THR A CA  1 
ATOM   2384 C  C   . THR A 1 311 ? -14.616 -16.220 23.713  1.00 9.05  ?  312  THR A C   1 
ATOM   2385 O  O   . THR A 1 311 ? -15.560 -16.954 23.404  1.00 8.03  ?  312  THR A O   1 
ATOM   2386 C  CB  . THR A 1 311 ? -13.177 -17.589 25.220  1.00 9.41  ?  312  THR A CB  1 
ATOM   2387 O  OG1 . THR A 1 311 ? -12.466 -17.572 26.461  1.00 9.77  ?  312  THR A OG1 1 
ATOM   2388 C  CG2 . THR A 1 311 ? -12.152 -17.716 24.093  1.00 11.34 ?  312  THR A CG2 1 
ATOM   2389 N  N   . ILE A 1 312 ? -14.064 -15.347 22.874  1.00 7.76  ?  313  ILE A N   1 
ATOM   2390 C  CA  . ILE A 1 312 ? -14.377 -15.325 21.450  1.00 8.72  ?  313  ILE A CA  1 
ATOM   2391 C  C   . ILE A 1 312 ? -13.231 -16.004 20.718  1.00 7.77  ?  313  ILE A C   1 
ATOM   2392 O  O   . ILE A 1 312 ? -12.065 -15.636 20.903  1.00 9.17  ?  313  ILE A O   1 
ATOM   2393 C  CB  . ILE A 1 312 ? -14.565 -13.884 20.947  1.00 7.41  ?  313  ILE A CB  1 
ATOM   2394 C  CG1 . ILE A 1 312 ? -15.712 -13.205 21.696  1.00 9.49  ?  313  ILE A CG1 1 
ATOM   2395 C  CG2 . ILE A 1 312 ? -14.800 -13.881 19.438  1.00 8.91  ?  313  ILE A CG2 1 
ATOM   2396 C  CD1 . ILE A 1 312 ? -15.686 -11.669 21.594  1.00 9.77  ?  313  ILE A CD1 1 
ATOM   2397 N  N   . VAL A 1 313 ? -13.556 -17.012 19.918  1.00 7.67  ?  314  VAL A N   1 
ATOM   2398 C  CA  . VAL A 1 313 ? -12.592 -17.690 19.055  1.00 8.61  ?  314  VAL A CA  1 
ATOM   2399 C  C   . VAL A 1 313 ? -12.866 -17.210 17.643  1.00 8.06  ?  314  VAL A C   1 
ATOM   2400 O  O   . VAL A 1 313 ? -13.971 -17.417 17.126  1.00 9.91  ?  314  VAL A O   1 
ATOM   2401 C  CB  . VAL A 1 313 ? -12.753 -19.217 19.111  1.00 7.91  ?  314  VAL A CB  1 
ATOM   2402 C  CG1 . VAL A 1 313 ? -11.770 -19.889 18.154  1.00 10.22 ?  314  VAL A CG1 1 
ATOM   2403 C  CG2 . VAL A 1 313 ? -12.582 -19.736 20.531  1.00 9.35  ?  314  VAL A CG2 1 
ATOM   2404 N  N   . ILE A 1 314 ? -11.876 -16.587 17.009  1.00 8.11  ?  315  ILE A N   1 
ATOM   2405 C  CA  . ILE A 1 314 ? -12.055 -16.060 15.661  1.00 7.00  ?  315  ILE A CA  1 
ATOM   2406 C  C   . ILE A 1 314 ? -11.049 -16.706 14.720  1.00 7.49  ?  315  ILE A C   1 
ATOM   2407 O  O   . ILE A 1 314 ? -9.878  -16.900 15.071  1.00 8.56  ?  315  ILE A O   1 
ATOM   2408 C  CB  . ILE A 1 314 ? -11.968 -14.513 15.627  1.00 7.44  ?  315  ILE A CB  1 
ATOM   2409 C  CG1 . ILE A 1 314 ? -12.309 -13.980 14.229  1.00 7.48  ?  315  ILE A CG1 1 
ATOM   2410 C  CG2 . ILE A 1 314 ? -10.592 -14.032 16.102  1.00 10.06 ?  315  ILE A CG2 1 
ATOM   2411 C  CD1 . ILE A 1 314 ? -12.448 -12.460 14.192  1.00 8.95  ?  315  ILE A CD1 1 
ATOM   2412 N  N   . ALA A 1 315 ? -11.519 -17.038 13.522  1.00 7.28  ?  316  ALA A N   1 
ATOM   2413 C  CA  . ALA A 1 315 ? -10.670 -17.457 12.409  1.00 7.07  ?  316  ALA A CA  1 
ATOM   2414 C  C   . ALA A 1 315 ? -10.695 -16.369 11.343  1.00 8.36  ?  316  ALA A C   1 
ATOM   2415 O  O   . ALA A 1 315 ? -11.771 -15.904 10.957  1.00 9.28  ?  316  ALA A O   1 
ATOM   2416 C  CB  . ALA A 1 315 ? -11.155 -18.782 11.808  1.00 9.76  ?  316  ALA A CB  1 
ATOM   2417 N  N   . ALA A 1 316 ? -9.515  -15.954 10.877  1.00 8.15  ?  317  ALA A N   1 
ATOM   2418 C  CA  . ALA A 1 316 ? -9.415  -14.948 9.824   1.00 7.60  ?  317  ALA A CA  1 
ATOM   2419 C  C   . ALA A 1 316 ? -8.107  -15.171 9.084   1.00 8.87  ?  317  ALA A C   1 
ATOM   2420 O  O   . ALA A 1 316 ? -7.081  -15.446 9.706   1.00 9.08  ?  317  ALA A O   1 
ATOM   2421 C  CB  . ALA A 1 316 ? -9.451  -13.536 10.421  1.00 8.56  ?  317  ALA A CB  1 
ATOM   2422 N  N   . ALA A 1 317 ? -8.132  -15.043 7.754   1.00 7.73  ?  318  ALA A N   1 
ATOM   2423 C  CA  . ALA A 1 317 ? -6.945  -15.392 6.974   1.00 8.32  ?  318  ALA A CA  1 
ATOM   2424 C  C   . ALA A 1 317 ? -5.819  -14.366 7.129   1.00 8.43  ?  318  ALA A C   1 
ATOM   2425 O  O   . ALA A 1 317 ? -4.642  -14.737 7.115   1.00 8.74  ?  318  ALA A O   1 
ATOM   2426 C  CB  . ALA A 1 317 ? -7.309  -15.579 5.505   1.00 9.07  ?  318  ALA A CB  1 
ATOM   2427 N  N   . LEU A 1 318 ? -6.146  -13.073 7.256   1.00 7.51  ?  319  LEU A N   1 
ATOM   2428 C  CA  . LEU A 1 318 ? -5.140  -12.021 7.456   1.00 8.69  ?  319  LEU A CA  1 
ATOM   2429 C  C   . LEU A 1 318 ? -4.069  -12.039 6.364   1.00 8.30  ?  319  LEU A C   1 
ATOM   2430 O  O   . LEU A 1 318 ? -2.878  -11.898 6.637   1.00 8.81  ?  319  LEU A O   1 
ATOM   2431 C  CB  . LEU A 1 318 ? -4.506  -12.102 8.852   1.00 8.63  ?  319  LEU A CB  1 
ATOM   2432 C  CG  . LEU A 1 318 ? -5.431  -12.177 10.071  1.00 8.91  ?  319  LEU A CG  1 
ATOM   2433 C  CD1 . LEU A 1 318 ? -4.624  -12.058 11.377  1.00 9.52  ?  319  LEU A CD1 1 
ATOM   2434 C  CD2 . LEU A 1 318 ? -6.531  -11.117 10.023  1.00 10.13 ?  319  LEU A CD2 1 
ATOM   2435 N  N   . ALA A 1 319 ? -4.480  -12.201 5.108   1.00 7.97  ?  320  ALA A N   1 
ATOM   2436 C  CA  . ALA A 1 319 ? -3.480  -12.376 4.057   1.00 8.87  ?  320  ALA A CA  1 
ATOM   2437 C  C   . ALA A 1 319 ? -2.558  -11.168 3.916   1.00 10.98 ?  320  ALA A C   1 
ATOM   2438 O  O   . ALA A 1 319 ? -1.409  -11.324 3.492   1.00 13.15 ?  320  ALA A O   1 
ATOM   2439 C  CB  . ALA A 1 319 ? -4.140  -12.689 2.715   1.00 9.91  ?  320  ALA A CB  1 
ATOM   2440 N  N   . GLU A 1 320 ? -3.028  -9.965  4.256   1.00 7.84  ?  321  GLU A N   1 
ATOM   2441 C  CA  . GLU A 1 320 ? -2.210  -8.764  4.169   1.00 10.65 ?  321  GLU A CA  1 
ATOM   2442 C  C   . GLU A 1 320 ? -1.505  -8.416  5.478   1.00 10.96 ?  321  GLU A C   1 
ATOM   2443 O  O   . GLU A 1 320 ? -0.650  -7.526  5.493   1.00 12.75 ?  321  GLU A O   1 
ATOM   2444 C  CB  . GLU A 1 320 ? -3.068  -7.591  3.667   1.00 8.79  ?  321  GLU A CB  1 
ATOM   2445 C  CG  . GLU A 1 320 ? -2.306  -6.317  3.294   1.00 12.03 ?  321  GLU A CG  1 
ATOM   2446 C  CD  . GLU A 1 320 ? -3.234  -5.203  2.835   1.00 12.73 ?  321  GLU A CD  1 
ATOM   2447 O  OE1 . GLU A 1 320 ? -2.860  -4.017  2.966   1.00 13.56 ?  321  GLU A OE1 1 
ATOM   2448 O  OE2 . GLU A 1 320 ? -4.323  -5.518  2.308   1.00 11.75 -1 321  GLU A OE2 1 
ATOM   2449 N  N   . GLY A 1 321 ? -1.811  -9.103  6.574   1.00 9.75  ?  322  GLY A N   1 
ATOM   2450 C  CA  . GLY A 1 321 ? -1.104  -8.871  7.818   1.00 10.34 ?  322  GLY A CA  1 
ATOM   2451 C  C   . GLY A 1 321 ? -1.890  -8.050  8.818   1.00 8.32  ?  322  GLY A C   1 
ATOM   2452 O  O   . GLY A 1 321 ? -3.112  -8.181  8.916   1.00 9.78  ?  322  GLY A O   1 
ATOM   2453 N  N   . LEU A 1 322 ? -1.195  -7.188  9.560   1.00 9.13  ?  323  LEU A N   1 
ATOM   2454 C  CA  . LEU A 1 322 ? -1.823  -6.485  10.681  1.00 9.32  ?  323  LEU A CA  1 
ATOM   2455 C  C   . LEU A 1 322 ? -2.638  -5.273  10.250  1.00 9.54  ?  323  LEU A C   1 
ATOM   2456 O  O   . LEU A 1 322 ? -3.659  -4.971  10.874  1.00 10.20 ?  323  LEU A O   1 
ATOM   2457 C  CB  . LEU A 1 322 ? -0.777  -6.071  11.719  1.00 10.40 ?  323  LEU A CB  1 
ATOM   2458 C  CG  . LEU A 1 322 ? -0.080  -7.191  12.489  1.00 10.05 ?  323  LEU A CG  1 
ATOM   2459 C  CD1 . LEU A 1 322 ? 0.834   -6.578  13.527  1.00 14.59 ?  323  LEU A CD1 1 
ATOM   2460 C  CD2 . LEU A 1 322 ? -1.128  -8.054  13.180  1.00 13.96 ?  323  LEU A CD2 1 
ATOM   2461 N  N   . GLY A 1 323 ? -2.190  -4.553  9.228   1.00 9.96  ?  324  GLY A N   1 
ATOM   2462 C  CA  . GLY A 1 323 ? -2.810  -3.291  8.871   1.00 9.83  ?  324  GLY A CA  1 
ATOM   2463 C  C   . GLY A 1 323 ? -1.797  -2.175  8.716   1.00 10.16 ?  324  GLY A C   1 
ATOM   2464 O  O   . GLY A 1 323 ? -0.619  -2.424  8.447   1.00 11.09 ?  324  GLY A O   1 
ATOM   2465 N  N   . SER A 1 324 ? -2.244  -0.939  8.887   1.00 9.15  ?  325  SER A N   1 
ATOM   2466 C  CA  . SER A 1 324 ? -1.413  0.211   8.564   1.00 9.56  ?  325  SER A CA  1 
ATOM   2467 C  C   . SER A 1 324 ? -0.220  0.346   9.508   1.00 9.88  ?  325  SER A C   1 
ATOM   2468 O  O   . SER A 1 324 ? -0.240  -0.160  10.635  1.00 9.83  ?  325  SER A O   1 
ATOM   2469 C  CB  . SER A 1 324 ? -2.272  1.468   8.610   1.00 9.90  ?  325  SER A CB  1 
ATOM   2470 O  OG  . SER A 1 324 ? -2.493  1.867   9.951   1.00 10.05 ?  325  SER A OG  1 
ATOM   2471 N  N   . PRO A 1 325 ? 0.838   1.043   9.068   1.00 11.02 ?  326  PRO A N   1 
ATOM   2472 C  CA  . PRO A 1 325 ? 1.957   1.318   9.986   1.00 12.66 ?  326  PRO A CA  1 
ATOM   2473 C  C   . PRO A 1 325 ? 1.526   2.061   11.232  1.00 13.02 ?  326  PRO A C   1 
ATOM   2474 O  O   . PRO A 1 325 ? 2.043   1.794   12.324  1.00 12.71 ?  326  PRO A O   1 
ATOM   2475 C  CB  . PRO A 1 325 ? 2.899   2.164   9.119   1.00 13.49 ?  326  PRO A CB  1 
ATOM   2476 C  CG  . PRO A 1 325 ? 2.607   1.680   7.717   1.00 18.48 ?  326  PRO A CG  1 
ATOM   2477 C  CD  . PRO A 1 325 ? 1.106   1.575   7.717   1.00 13.23 ?  326  PRO A CD  1 
ATOM   2478 N  N   . GLU A 1 326 ? 0.571   2.981   11.096  1.00 11.43 ?  327  GLU A N   1 
ATOM   2479 C  CA  . GLU A 1 326 ? 0.114   3.761   12.236  1.00 10.96 ?  327  GLU A CA  1 
ATOM   2480 C  C   . GLU A 1 326 ? -0.642  2.889   13.229  1.00 11.07 ?  327  GLU A C   1 
ATOM   2481 O  O   . GLU A 1 326 ? -0.429  2.992   14.441  1.00 12.27 ?  327  GLU A O   1 
ATOM   2482 C  CB  . GLU A 1 326 ? -0.761  4.902   11.722  1.00 12.13 ?  327  GLU A CB  1 
ATOM   2483 C  CG  . GLU A 1 326 ? 0.020   5.934   10.899  1.00 15.83 ?  327  GLU A CG  1 
ATOM   2484 C  CD  . GLU A 1 326 ? 0.076   5.583   9.417   1.00 19.36 ?  327  GLU A CD  1 
ATOM   2485 O  OE1 . GLU A 1 326 ? -0.490  4.543   9.006   1.00 15.58 ?  327  GLU A OE1 1 
ATOM   2486 O  OE2 . GLU A 1 326 ? 0.703   6.344   8.647   1.00 23.58 -1 327  GLU A OE2 1 
ATOM   2487 N  N   . PHE A 1 327 ? -1.519  2.013   12.730  1.00 10.19 ?  328  PHE A N   1 
ATOM   2488 C  CA  . PHE A 1 327 ? -2.200  1.057   13.597  1.00 9.73  ?  328  PHE A CA  1 
ATOM   2489 C  C   . PHE A 1 327 ? -1.187  0.185   14.334  1.00 9.73  ?  328  PHE A C   1 
ATOM   2490 O  O   . PHE A 1 327 ? -1.258  0.027   15.561  1.00 11.16 ?  328  PHE A O   1 
ATOM   2491 C  CB  . PHE A 1 327 ? -3.150  0.223   12.729  1.00 10.23 ?  328  PHE A CB  1 
ATOM   2492 C  CG  . PHE A 1 327 ? -3.889  -0.855  13.461  1.00 9.15  ?  328  PHE A CG  1 
ATOM   2493 C  CD1 . PHE A 1 327 ? -4.803  -0.537  14.452  1.00 9.65  ?  328  PHE A CD1 1 
ATOM   2494 C  CD2 . PHE A 1 327 ? -3.718  -2.196  13.114  1.00 9.65  ?  328  PHE A CD2 1 
ATOM   2495 C  CE1 . PHE A 1 327 ? -5.501  -1.534  15.124  1.00 8.78  ?  328  PHE A CE1 1 
ATOM   2496 C  CE2 . PHE A 1 327 ? -4.424  -3.203  13.772  1.00 9.91  ?  328  PHE A CE2 1 
ATOM   2497 C  CZ  . PHE A 1 327 ? -5.326  -2.864  14.777  1.00 9.95  ?  328  PHE A CZ  1 
ATOM   2498 N  N   . GLN A 1 328 ? -0.194  -0.335  13.605  1.00 8.99  ?  329  GLN A N   1 
ATOM   2499 C  CA  . GLN A 1 328 ? 0.822   -1.181  14.222  1.00 11.74 ?  329  GLN A CA  1 
ATOM   2500 C  C   . GLN A 1 328 ? 1.619   -0.419  15.274  1.00 12.68 ?  329  GLN A C   1 
ATOM   2501 O  O   . GLN A 1 328 ? 1.980   -0.984  16.314  1.00 12.39 ?  329  GLN A O   1 
ATOM   2502 C  CB  . GLN A 1 328 ? 1.741   -1.745  13.135  1.00 10.04 ?  329  GLN A CB  1 
ATOM   2503 C  CG  . GLN A 1 328 ? 1.029   -2.732  12.223  1.00 10.29 ?  329  GLN A CG  1 
ATOM   2504 C  CD  . GLN A 1 328 ? 1.965   -3.409  11.262  1.00 12.56 ?  329  GLN A CD  1 
ATOM   2505 O  OE1 . GLN A 1 328 ? 3.043   -3.881  11.642  1.00 15.64 ?  329  GLN A OE1 1 
ATOM   2506 N  NE2 . GLN A 1 328 ? 1.557   -3.480  9.996   1.00 13.48 ?  329  GLN A NE2 1 
ATOM   2507 N  N   . SER A 1 329 ? 1.883   0.870   15.037  1.00 11.75 ?  330  SER A N   1 
ATOM   2508 C  CA  . SER A 1 329 ? 2.720   1.635   15.960  1.00 11.50 ?  330  SER A CA  1 
ATOM   2509 C  C   . SER A 1 329 ? 2.072   1.775   17.329  1.00 12.36 ?  330  SER A C   1 
ATOM   2510 O  O   . SER A 1 329 ? 2.778   1.924   18.334  1.00 13.75 ?  330  SER A O   1 
ATOM   2511 C  CB  . SER A 1 329 ? 3.040   3.021   15.383  1.00 13.96 ?  330  SER A CB  1 
ATOM   2512 O  OG  . SER A 1 329 ? 1.930   3.906   15.498  1.00 15.79 ?  330  SER A OG  1 
ATOM   2513 N  N   . LEU A 1 330 ? 0.742   1.748   17.395  1.00 12.20 ?  331  LEU A N   1 
ATOM   2514 C  CA  . LEU A 1 330 ? 0.066   1.958   18.672  1.00 11.26 ?  331  LEU A CA  1 
ATOM   2515 C  C   . LEU A 1 330 ? 0.331   0.819   19.646  1.00 12.52 ?  331  LEU A C   1 
ATOM   2516 O  O   . LEU A 1 330 ? 0.440   1.050   20.855  1.00 12.27 ?  331  LEU A O   1 
ATOM   2517 C  CB  . LEU A 1 330 ? -1.432  2.154   18.456  1.00 13.39 ?  331  LEU A CB  1 
ATOM   2518 C  CG  . LEU A 1 330 ? -1.769  3.471   17.758  1.00 13.56 ?  331  LEU A CG  1 
ATOM   2519 C  CD1 . LEU A 1 330 ? -3.175  3.393   17.228  1.00 20.36 ?  331  LEU A CD1 1 
ATOM   2520 C  CD2 . LEU A 1 330 ? -1.614  4.656   18.693  1.00 16.43 ?  331  LEU A CD2 1 
ATOM   2521 N  N   . PHE A 1 331 ? 0.428   -0.416  19.144  1.00 12.44 ?  332  PHE A N   1 
ATOM   2522 C  CA  . PHE A 1 331 ? 0.737   -1.545  20.017  1.00 11.38 ?  332  PHE A CA  1 
ATOM   2523 C  C   . PHE A 1 331 ? 2.133   -1.401  20.597  1.00 13.14 ?  332  PHE A C   1 
ATOM   2524 O  O   . PHE A 1 331 ? 2.379   -1.761  21.758  1.00 15.87 ?  332  PHE A O   1 
ATOM   2525 C  CB  . PHE A 1 331 ? 0.666   -2.854  19.226  1.00 12.21 ?  332  PHE A CB  1 
ATOM   2526 C  CG  . PHE A 1 331 ? -0.705  -3.194  18.704  1.00 12.13 ?  332  PHE A CG  1 
ATOM   2527 C  CD1 . PHE A 1 331 ? -1.100  -2.783  17.441  1.00 12.48 ?  332  PHE A CD1 1 
ATOM   2528 C  CD2 . PHE A 1 331 ? -1.575  -3.971  19.449  1.00 11.39 ?  332  PHE A CD2 1 
ATOM   2529 C  CE1 . PHE A 1 331 ? -2.354  -3.110  16.948  1.00 14.44 ?  332  PHE A CE1 1 
ATOM   2530 C  CE2 . PHE A 1 331 ? -2.830  -4.299  18.962  1.00 11.29 ?  332  PHE A CE2 1 
ATOM   2531 C  CZ  . PHE A 1 331 ? -3.219  -3.869  17.705  1.00 12.79 ?  332  PHE A CZ  1 
ATOM   2532 N  N   . GLU A 1 332 ? 3.069   -0.898  19.792  1.00 16.24 ?  333  GLU A N   1 
ATOM   2533 C  CA  . GLU A 1 332 ? 4.429   -0.693  20.271  1.00 17.16 ?  333  GLU A CA  1 
ATOM   2534 C  C   . GLU A 1 332 ? 4.467   0.393   21.333  1.00 17.23 ?  333  GLU A C   1 
ATOM   2535 O  O   . GLU A 1 332 ? 5.239   0.302   22.296  1.00 20.61 ?  333  GLU A O   1 
ATOM   2536 C  CB  . GLU A 1 332 ? 5.325   -0.310  19.089  1.00 19.50 ?  333  GLU A CB  1 
ATOM   2537 C  CG  . GLU A 1 332 ? 5.428   -1.391  18.021  1.00 25.33 ?  333  GLU A CG  1 
ATOM   2538 C  CD  . GLU A 1 332 ? 5.893   -2.722  18.579  1.00 41.45 ?  333  GLU A CD  1 
ATOM   2539 O  OE1 . GLU A 1 332 ? 6.920   -2.737  19.294  1.00 44.23 ?  333  GLU A OE1 1 
ATOM   2540 O  OE2 . GLU A 1 332 ? 5.225   -3.749  18.319  1.00 46.97 -1 333  GLU A OE2 1 
ATOM   2541 N  N   . GLU A 1 333 ? 3.615   1.407   21.197  1.00 13.99 ?  334  GLU A N   1 
ATOM   2542 C  CA  . GLU A 1 333 ? 3.654   2.554   22.095  1.00 15.46 ?  334  GLU A CA  1 
ATOM   2543 C  C   . GLU A 1 333 ? 2.946   2.277   23.413  1.00 15.87 ?  334  GLU A C   1 
ATOM   2544 O  O   . GLU A 1 333 ? 3.288   2.884   24.434  1.00 16.61 ?  334  GLU A O   1 
ATOM   2545 C  CB  . GLU A 1 333 ? 2.988   3.746   21.408  1.00 15.17 ?  334  GLU A CB  1 
ATOM   2546 C  CG  . GLU A 1 333 ? 3.793   4.316   20.258  1.00 26.00 ?  334  GLU A CG  1 
ATOM   2547 C  CD  . GLU A 1 333 ? 3.120   5.517   19.628  1.00 37.02 ?  334  GLU A CD  1 
ATOM   2548 O  OE1 . GLU A 1 333 ? 1.881   5.632   19.747  1.00 36.70 ?  334  GLU A OE1 1 
ATOM   2549 O  OE2 . GLU A 1 333 ? 3.825   6.330   18.993  1.00 48.98 -1 334  GLU A OE2 1 
ATOM   2550 N  N   . HIS A 1 334 ? 1.965   1.376   23.420  1.00 13.46 ?  335  HIS A N   1 
ATOM   2551 C  CA  . HIS A 1 334 ? 1.131   1.119   24.592  1.00 12.53 ?  335  HIS A CA  1 
ATOM   2552 C  C   . HIS A 1 334 ? 1.058   -0.379  24.833  1.00 15.64 ?  335  HIS A C   1 
ATOM   2553 O  O   . HIS A 1 334 ? 0.201   -1.057  24.240  1.00 16.29 ?  335  HIS A O   1 
ATOM   2554 C  CB  . HIS A 1 334 ? -0.267  1.689   24.396  1.00 13.87 ?  335  HIS A CB  1 
ATOM   2555 C  CG  . HIS A 1 334 ? -0.270  3.131   24.013  1.00 16.08 ?  335  HIS A CG  1 
ATOM   2556 N  ND1 . HIS A 1 334 ? -0.041  4.131   24.933  1.00 16.67 ?  335  HIS A ND1 1 
ATOM   2557 C  CD2 . HIS A 1 334 ? -0.466  3.748   22.821  1.00 20.41 ?  335  HIS A CD2 1 
ATOM   2558 C  CE1 . HIS A 1 334 ? -0.094  5.304   24.326  1.00 19.71 ?  335  HIS A CE1 1 
ATOM   2559 N  NE2 . HIS A 1 334 ? -0.355  5.100   23.046  1.00 19.98 ?  335  HIS A NE2 1 
ATOM   2560 N  N   . PRO A 1 335 ? 1.901   -0.918  25.719  1.00 15.09 ?  336  PRO A N   1 
ATOM   2561 C  CA  . PRO A 1 335 ? 1.881   -2.370  25.972  1.00 16.94 ?  336  PRO A CA  1 
ATOM   2562 C  C   . PRO A 1 335 ? 0.547   -2.899  26.463  1.00 15.47 ?  336  PRO A C   1 
ATOM   2563 O  O   . PRO A 1 335 ? 0.206   -4.052  26.169  1.00 13.76 ?  336  PRO A O   1 
ATOM   2564 C  CB  . PRO A 1 335 ? 2.984   -2.547  27.026  1.00 20.80 ?  336  PRO A CB  1 
ATOM   2565 C  CG  . PRO A 1 335 ? 3.897   -1.375  26.797  1.00 21.14 ?  336  PRO A CG  1 
ATOM   2566 C  CD  . PRO A 1 335 ? 2.964   -0.242  26.487  1.00 16.28 ?  336  PRO A CD  1 
ATOM   2567 N  N   . THR A 1 336 ? -0.219  -2.119  27.218  1.00 11.47 ?  337  THR A N   1 
ATOM   2568 C  CA  . THR A 1 336 ? -1.512  -2.579  27.697  1.00 14.11 ?  337  THR A CA  1 
ATOM   2569 C  C   . THR A 1 336 ? -2.631  -1.763  27.071  1.00 11.89 ?  337  THR A C   1 
ATOM   2570 O  O   . THR A 1 336 ? -2.466  -0.580  26.757  1.00 11.67 ?  337  THR A O   1 
ATOM   2571 C  CB  . THR A 1 336 ? -1.629  -2.530  29.228  1.00 14.00 ?  337  THR A CB  1 
ATOM   2572 O  OG1 . THR A 1 336 ? -1.659  -1.166  29.668  1.00 17.06 ?  337  THR A OG1 1 
ATOM   2573 C  CG2 . THR A 1 336 ? -0.473  -3.282  29.893  1.00 15.96 ?  337  THR A CG2 1 
ATOM   2574 N  N   . LEU A 1 337 ? -3.783  -2.411  26.899  1.00 10.91 ?  338  LEU A N   1 
ATOM   2575 C  CA  . LEU A 1 337 ? -4.944  -1.702  26.373  1.00 11.03 ?  338  LEU A CA  1 
ATOM   2576 C  C   . LEU A 1 337 ? -5.439  -0.643  27.357  1.00 11.46 ?  338  LEU A C   1 
ATOM   2577 O  O   . LEU A 1 337 ? -5.929  0.410   26.935  1.00 10.95 ?  338  LEU A O   1 
ATOM   2578 C  CB  . LEU A 1 337 ? -6.047  -2.705  26.028  1.00 11.52 ?  338  LEU A CB  1 
ATOM   2579 C  CG  . LEU A 1 337 ? -5.756  -3.571  24.802  1.00 11.51 ?  338  LEU A CG  1 
ATOM   2580 C  CD1 . LEU A 1 337 ? -6.755  -4.730  24.747  1.00 12.79 ?  338  LEU A CD1 1 
ATOM   2581 C  CD2 . LEU A 1 337 ? -5.787  -2.743  23.526  1.00 13.72 ?  338  LEU A CD2 1 
ATOM   2582 N  N   . GLU A 1 338 ? -5.323  -0.902  28.665  1.00 11.33 ?  339  GLU A N   1 
ATOM   2583 C  CA  . GLU A 1 338 ? -5.675  0.115   29.654  1.00 11.37 ?  339  GLU A CA  1 
ATOM   2584 C  C   . GLU A 1 338 ? -4.844  1.376   29.462  1.00 11.54 ?  339  GLU A C   1 
ATOM   2585 O  O   . GLU A 1 338 ? -5.376  2.493   29.515  1.00 11.44 ?  339  GLU A O   1 
ATOM   2586 C  CB  . GLU A 1 338 ? -5.465  -0.426  31.070  1.00 12.18 ?  339  GLU A CB  1 
ATOM   2587 C  CG  . GLU A 1 338 ? -6.185  0.354   32.186  1.00 14.23 ?  339  GLU A CG  1 
ATOM   2588 C  CD  . GLU A 1 338 ? -5.429  1.595   32.633  1.00 15.77 ?  339  GLU A CD  1 
ATOM   2589 O  OE1 . GLU A 1 338 ? -6.079  2.527   33.160  1.00 14.95 ?  339  GLU A OE1 1 
ATOM   2590 O  OE2 . GLU A 1 338 ? -4.195  1.654   32.447  1.00 15.64 -1 339  GLU A OE2 1 
ATOM   2591 N  N   . GLY A 1 339 ? -3.536  1.219   29.268  1.00 10.07 ?  340  GLY A N   1 
ATOM   2592 C  CA  . GLY A 1 339 ? -2.683  2.376   29.067  1.00 11.04 ?  340  GLY A CA  1 
ATOM   2593 C  C   . GLY A 1 339 ? -2.989  3.095   27.766  1.00 11.25 ?  340  GLY A C   1 
ATOM   2594 O  O   . GLY A 1 339 ? -2.972  4.332   27.715  1.00 11.84 ?  340  GLY A O   1 
ATOM   2595 N  N   . PHE A 1 340 ? -3.268  2.334   26.697  1.00 11.31 ?  341  PHE A N   1 
ATOM   2596 C  CA  . PHE A 1 340 ? -3.717  2.945   25.450  1.00 11.06 ?  341  PHE A CA  1 
ATOM   2597 C  C   . PHE A 1 340 ? -4.963  3.788   25.679  1.00 9.07  ?  341  PHE A C   1 
ATOM   2598 O  O   . PHE A 1 340 ? -5.049  4.932   25.206  1.00 11.60 ?  341  PHE A O   1 
ATOM   2599 C  CB  . PHE A 1 340 ? -3.985  1.865   24.397  1.00 12.00 ?  341  PHE A CB  1 
ATOM   2600 C  CG  . PHE A 1 340 ? -4.788  2.368   23.217  1.00 10.10 ?  341  PHE A CG  1 
ATOM   2601 C  CD1 . PHE A 1 340 ? -4.180  3.127   22.226  1.00 12.68 ?  341  PHE A CD1 1 
ATOM   2602 C  CD2 . PHE A 1 340 ? -6.136  2.076   23.100  1.00 11.10 ?  341  PHE A CD2 1 
ATOM   2603 C  CE1 . PHE A 1 340 ? -4.911  3.601   21.142  1.00 13.46 ?  341  PHE A CE1 1 
ATOM   2604 C  CE2 . PHE A 1 340 ? -6.882  2.542   22.019  1.00 11.44 ?  341  PHE A CE2 1 
ATOM   2605 C  CZ  . PHE A 1 340 ? -6.264  3.308   21.036  1.00 12.43 ?  341  PHE A CZ  1 
ATOM   2606 N  N   . MET A 1 341 ? -5.924  3.261   26.434  1.00 8.95  ?  342  MET A N   1 
ATOM   2607 C  CA  . MET A 1 341 ? -7.160  3.995   26.634  1.00 11.28 ?  342  MET A CA  1 
ATOM   2608 C  C   . MET A 1 341 ? -6.932  5.245   27.477  1.00 12.96 ?  342  MET A C   1 
ATOM   2609 O  O   . MET A 1 341 ? -7.539  6.292   27.216  1.00 12.35 ?  342  MET A O   1 
ATOM   2610 C  CB  . MET A 1 341 ? -8.215  3.097   27.268  1.00 12.31 ?  342  MET A CB  1 
ATOM   2611 C  CG  . MET A 1 341 ? -8.687  2.012   26.296  1.00 11.18 ?  342  MET A CG  1 
ATOM   2612 S  SD  . MET A 1 341 ? -9.616  2.706   24.917  1.00 12.37 ?  342  MET A SD  1 
ATOM   2613 C  CE  . MET A 1 341 ? -10.889 3.656   25.754  1.00 15.69 ?  342  MET A CE  1 
ATOM   2614 N  N   . GLU A 1 342 ? -6.075  5.158   28.497  1.00 10.59 ?  343  GLU A N   1 
ATOM   2615 C  CA  . GLU A 1 342 ? -5.748  6.357   29.264  1.00 11.77 ?  343  GLU A CA  1 
ATOM   2616 C  C   . GLU A 1 342 ? -5.200  7.443   28.351  1.00 10.67 ?  343  GLU A C   1 
ATOM   2617 O  O   . GLU A 1 342 ? -5.558  8.621   28.486  1.00 13.67 ?  343  GLU A O   1 
ATOM   2618 C  CB  . GLU A 1 342 ? -4.749  6.011   30.372  1.00 14.28 ?  343  GLU A CB  1 
ATOM   2619 C  CG  . GLU A 1 342 ? -5.378  5.315   31.563  1.00 13.40 ?  343  GLU A CG  1 
ATOM   2620 C  CD  . GLU A 1 342 ? -4.448  5.269   32.766  1.00 15.27 ?  343  GLU A CD  1 
ATOM   2621 O  OE1 . GLU A 1 342 ? -3.395  5.936   32.750  1.00 19.10 ?  343  GLU A OE1 1 
ATOM   2622 O  OE2 . GLU A 1 342 ? -4.795  4.601   33.758  1.00 16.05 -1 343  GLU A OE2 1 
ATOM   2623 N  N   . ALA A 1 343 ? -4.352  7.060   27.396  1.00 11.51 ?  344  ALA A N   1 
ATOM   2624 C  CA  . ALA A 1 343 ? -3.743  8.036   26.501  1.00 12.37 ?  344  ALA A CA  1 
ATOM   2625 C  C   . ALA A 1 343 ? -4.780  8.687   25.592  1.00 15.37 ?  344  ALA A C   1 
ATOM   2626 O  O   . ALA A 1 343 ? -4.813  9.916   25.461  1.00 15.45 ?  344  ALA A O   1 
ATOM   2627 C  CB  . ALA A 1 343 ? -2.620  7.385   25.691  1.00 14.22 ?  344  ALA A CB  1 
ATOM   2628 N  N   . ILE A 1 344 ? -5.645  7.891   24.958  1.00 13.00 ?  345  ILE A N   1 
ATOM   2629 C  CA  . ILE A 1 344 ? -6.577  8.491   24.004  1.00 13.95 ?  345  ILE A CA  1 
ATOM   2630 C  C   . ILE A 1 344 ? -7.713  9.236   24.687  1.00 17.94 ?  345  ILE A C   1 
ATOM   2631 O  O   . ILE A 1 344 ? -8.279  10.161  24.090  1.00 18.18 ?  345  ILE A O   1 
ATOM   2632 C  CB  . ILE A 1 344 ? -7.089  7.525   22.920  1.00 14.57 ?  345  ILE A CB  1 
ATOM   2633 C  CG1 . ILE A 1 344 ? -7.961  6.412   23.515  1.00 13.23 ?  345  ILE A CG1 1 
ATOM   2634 C  CG2 . ILE A 1 344 ? -5.936  6.944   22.130  1.00 15.45 ?  345  ILE A CG2 1 
ATOM   2635 C  CD1 . ILE A 1 344 ? -8.916  5.774   22.494  1.00 13.58 ?  345  ILE A CD1 1 
ATOM   2636 N  N   . LEU A 1 345 ? -8.063  8.871   25.914  1.00 15.99 ?  346  LEU A N   1 
ATOM   2637 C  CA  . LEU A 1 345 ? -9.126  9.574   26.623  1.00 17.26 ?  346  LEU A CA  1 
ATOM   2638 C  C   . LEU A 1 345 ? -8.695  10.951  27.096  1.00 27.71 ?  346  LEU A C   1 
ATOM   2639 O  O   . LEU A 1 345 ? -9.518  11.675  27.671  1.00 34.78 ?  346  LEU A O   1 
ATOM   2640 C  CB  . LEU A 1 345 ? -9.648  8.728   27.782  1.00 18.45 ?  346  LEU A CB  1 
ATOM   2641 C  CG  . LEU A 1 345 ? -10.453 7.505   27.335  1.00 16.45 ?  346  LEU A CG  1 
ATOM   2642 C  CD1 . LEU A 1 345 ? -10.734 6.587   28.512  1.00 19.46 ?  346  LEU A CD1 1 
ATOM   2643 C  CD2 . LEU A 1 345 ? -11.738 7.936   26.663  1.00 22.67 ?  346  LEU A CD2 1 
ATOM   2644 N  N   . LYS A 1 346 ? -7.432  11.323  26.872  1.00 26.77 ?  347  LYS A N   1 
ATOM   2645 C  CA  . LYS A 1 346 ? -6.957  12.675  27.141  1.00 30.52 ?  347  LYS A CA  1 
ATOM   2646 C  C   . LYS A 1 346 ? -7.191  13.629  25.979  1.00 39.75 ?  347  LYS A C   1 
ATOM   2647 O  O   . LYS A 1 346 ? -7.226  14.845  26.197  1.00 38.68 ?  347  LYS A O   1 
ATOM   2648 C  CB  . LYS A 1 346 ? -5.464  12.657  27.475  1.00 30.74 ?  347  LYS A CB  1 
ATOM   2649 C  CG  . LYS A 1 346 ? -5.135  11.975  28.792  1.00 26.74 ?  347  LYS A CG  1 
ATOM   2650 N  N   . GLU A 1 347 ? -7.334  13.114  24.754  1.00 25.59 ?  348  GLU A N   1 
ATOM   2651 C  CA  . GLU A 1 347 ? -7.620  13.928  23.574  1.00 40.53 ?  348  GLU A CA  1 
ATOM   2652 C  C   . GLU A 1 347 ? -6.490  14.890  23.238  1.00 33.51 ?  348  GLU A C   1 
ATOM   2653 O  O   . GLU A 1 347 ? -6.685  15.836  22.467  1.00 38.24 ?  348  GLU A O   1 
ATOM   2654 C  CB  . GLU A 1 347 ? -8.954  14.678  23.691  1.00 42.54 ?  348  GLU A CB  1 
ATOM   2655 N  N   . GLU A 1 348 ? -5.308  14.672  23.817  1.00 39.46 ?  349  GLU A N   1 
ATOM   2656 C  CA  . GLU A 1 348 ? -4.162  15.509  23.485  1.00 42.11 ?  349  GLU A CA  1 
ATOM   2657 C  C   . GLU A 1 348 ? -3.651  15.221  22.080  1.00 47.69 ?  349  GLU A C   1 
ATOM   2658 O  O   . GLU A 1 348 ? -3.150  16.129  21.406  1.00 50.00 ?  349  GLU A O   1 
ATOM   2659 C  CB  . GLU A 1 348 ? -3.048  15.317  24.516  1.00 42.89 ?  349  GLU A CB  1 
ATOM   2660 N  N   . SER A 1 349 ? -3.786  13.978  21.614  1.00 40.37 ?  350  SER A N   1 
ATOM   2661 C  CA  . SER A 1 349 ? -3.256  13.572  20.319  1.00 38.82 ?  350  SER A CA  1 
ATOM   2662 C  C   . SER A 1 349 ? -4.196  12.571  19.657  1.00 27.84 ?  350  SER A C   1 
ATOM   2663 O  O   . SER A 1 349 ? -5.041  11.946  20.303  1.00 26.13 ?  350  SER A O   1 
ATOM   2664 C  CB  . SER A 1 349 ? -1.848  12.970  20.443  1.00 31.59 ?  350  SER A CB  1 
ATOM   2665 N  N   . PHE A 1 350 ? -4.026  12.424  18.347  1.00 18.58 ?  351  PHE A N   1 
ATOM   2666 C  CA  . PHE A 1 350 ? -4.846  11.543  17.525  1.00 18.11 ?  351  PHE A CA  1 
ATOM   2667 C  C   . PHE A 1 350 ? -3.896  10.816  16.591  1.00 15.13 ?  351  PHE A C   1 
ATOM   2668 O  O   . PHE A 1 350 ? -3.018  11.446  15.995  1.00 19.48 ?  351  PHE A O   1 
ATOM   2669 C  CB  . PHE A 1 350 ? -5.829  12.372  16.686  1.00 15.36 ?  351  PHE A CB  1 
ATOM   2670 C  CG  . PHE A 1 350 ? -6.960  12.977  17.476  1.00 15.34 ?  351  PHE A CG  1 
ATOM   2671 C  CD1 . PHE A 1 350 ? -8.026  12.204  17.899  1.00 19.33 ?  351  PHE A CD1 1 
ATOM   2672 C  CD2 . PHE A 1 350 ? -6.953  14.327  17.784  1.00 20.61 ?  351  PHE A CD2 1 
ATOM   2673 C  CE1 . PHE A 1 350 ? -9.067  12.763  18.621  1.00 17.44 ?  351  PHE A CE1 1 
ATOM   2674 C  CE2 . PHE A 1 350 ? -7.984  14.892  18.499  1.00 16.52 ?  351  PHE A CE2 1 
ATOM   2675 C  CZ  . PHE A 1 350 ? -9.047  14.114  18.915  1.00 21.45 ?  351  PHE A CZ  1 
ATOM   2676 N  N   . THR A 1 351 ? -4.053  9.498   16.474  1.00 11.78 ?  352  THR A N   1 
ATOM   2677 C  CA  . THR A 1 351 ? -3.259  8.686   15.566  1.00 12.85 ?  352  THR A CA  1 
ATOM   2678 C  C   . THR A 1 351 ? -4.203  7.978   14.608  1.00 10.98 ?  352  THR A C   1 
ATOM   2679 O  O   . THR A 1 351 ? -5.261  7.487   15.016  1.00 10.51 ?  352  THR A O   1 
ATOM   2680 C  CB  . THR A 1 351 ? -2.430  7.644   16.350  1.00 12.92 ?  352  THR A CB  1 
ATOM   2681 O  OG1 . THR A 1 351 ? -1.574  8.318   17.287  1.00 15.38 ?  352  THR A OG1 1 
ATOM   2682 C  CG2 . THR A 1 351 ? -1.578  6.788   15.420  1.00 13.45 ?  352  THR A CG2 1 
ATOM   2683 N  N   . VAL A 1 352 ? -3.828  7.963   13.330  1.00 10.64 ?  353  VAL A N   1 
ATOM   2684 C  CA  . VAL A 1 352 ? -4.611  7.242   12.338  1.00 11.07 ?  353  VAL A CA  1 
ATOM   2685 C  C   . VAL A 1 352 ? -4.817  5.818   12.818  1.00 10.36 ?  353  VAL A C   1 
ATOM   2686 O  O   . VAL A 1 352 ? -3.877  5.163   13.287  1.00 11.57 ?  353  VAL A O   1 
ATOM   2687 C  CB  . VAL A 1 352 ? -3.897  7.285   10.974  1.00 10.60 ?  353  VAL A CB  1 
ATOM   2688 C  CG1 . VAL A 1 352 ? -4.459  6.219   10.023  1.00 14.38 ?  353  VAL A CG1 1 
ATOM   2689 C  CG2 . VAL A 1 352 ? -3.996  8.691   10.373  1.00 12.76 ?  353  VAL A CG2 1 
ATOM   2690 N  N   . ASP A 1 353 ? -6.062  5.350   12.746  1.00 8.85  ?  354  ASP A N   1 
ATOM   2691 C  CA  . ASP A 1 353 ? -6.470  3.970   13.026  1.00 9.82  ?  354  ASP A CA  1 
ATOM   2692 C  C   . ASP A 1 353 ? -6.551  3.650   14.514  1.00 9.88  ?  354  ASP A C   1 
ATOM   2693 O  O   . ASP A 1 353 ? -6.816  2.497   14.866  1.00 10.47 ?  354  ASP A O   1 
ATOM   2694 C  CB  . ASP A 1 353 ? -5.640  2.941   12.242  1.00 9.40  ?  354  ASP A CB  1 
ATOM   2695 C  CG  . ASP A 1 353 ? -5.864  3.046   10.736  1.00 12.70 ?  354  ASP A CG  1 
ATOM   2696 O  OD1 . ASP A 1 353 ? -5.111  2.424   9.953   1.00 12.57 ?  354  ASP A OD1 1 
ATOM   2697 O  OD2 . ASP A 1 353 ? -6.823  3.738   10.328  1.00 15.50 -1 354  ASP A OD2 1 
ATOM   2698 N  N   . GLN A 1 354 ? -6.386  4.637   15.403  1.00 10.12 ?  355  GLN A N   1 
ATOM   2699 C  CA  . GLN A 1 354 ? -6.488  4.351   16.832  1.00 8.85  ?  355  GLN A CA  1 
ATOM   2700 C  C   . GLN A 1 354 ? -7.874  3.869   17.213  1.00 10.28 ?  355  GLN A C   1 
ATOM   2701 O  O   . GLN A 1 354 ? -8.022  3.140   18.207  1.00 10.56 ?  355  GLN A O   1 
ATOM   2702 C  CB  . GLN A 1 354 ? -6.113  5.594   17.657  1.00 9.35  ?  355  GLN A CB  1 
ATOM   2703 C  CG  . GLN A 1 354 ? -7.152  6.709   17.620  1.00 11.62 ?  355  GLN A CG  1 
ATOM   2704 C  CD  . GLN A 1 354 ? -6.784  7.868   18.508  1.00 14.73 ?  355  GLN A CD  1 
ATOM   2705 O  OE1 . GLN A 1 354 ? -5.630  8.279   18.541  1.00 15.14 ?  355  GLN A OE1 1 
ATOM   2706 N  NE2 . GLN A 1 354 ? -7.759  8.398   19.229  1.00 12.66 ?  355  GLN A NE2 1 
ATOM   2707 N  N   . TRP A 1 355 ? -8.887  4.252   16.433  1.00 9.88  ?  356  TRP A N   1 
ATOM   2708 C  CA  . TRP A 1 355 ? -10.257 3.873   16.737  1.00 9.12  ?  356  TRP A CA  1 
ATOM   2709 C  C   . TRP A 1 355 ? -10.431 2.355   16.772  1.00 7.88  ?  356  TRP A C   1 
ATOM   2710 O  O   . TRP A 1 355 ? -11.228 1.845   17.565  1.00 9.43  ?  356  TRP A O   1 
ATOM   2711 C  CB  . TRP A 1 355 ? -11.204 4.505   15.716  1.00 9.31  ?  356  TRP A CB  1 
ATOM   2712 C  CG  . TRP A 1 355 ? -10.676 4.528   14.303  1.00 7.98  ?  356  TRP A CG  1 
ATOM   2713 C  CD1 . TRP A 1 355 ? -10.758 3.517   13.386  1.00 8.87  ?  356  TRP A CD1 1 
ATOM   2714 C  CD2 . TRP A 1 355 ? -10.018 5.615   13.640  1.00 8.44  ?  356  TRP A CD2 1 
ATOM   2715 N  NE1 . TRP A 1 355 ? -10.194 3.912   12.195  1.00 9.79  ?  356  TRP A NE1 1 
ATOM   2716 C  CE2 . TRP A 1 355 ? -9.724  5.191   12.328  1.00 8.70  ?  356  TRP A CE2 1 
ATOM   2717 C  CE3 . TRP A 1 355 ? -9.636  6.898   14.031  1.00 9.39  ?  356  TRP A CE3 1 
ATOM   2718 C  CZ2 . TRP A 1 355 ? -9.084  6.016   11.402  1.00 9.41  ?  356  TRP A CZ2 1 
ATOM   2719 C  CZ3 . TRP A 1 355 ? -8.997  7.715   13.113  1.00 9.31  ?  356  TRP A CZ3 1 
ATOM   2720 C  CH2 . TRP A 1 355 ? -8.732  7.272   11.815  1.00 9.73  ?  356  TRP A CH2 1 
ATOM   2721 N  N   . GLN A 1 356 ? -9.715  1.612   15.922  1.00 8.04  ?  357  GLN A N   1 
ATOM   2722 C  CA  A GLN A 1 356 ? -9.857  0.163   15.940  0.55 8.20  ?  357  GLN A CA  1 
ATOM   2723 C  CA  B GLN A 1 356 ? -9.857  0.154   15.947  0.45 8.22  ?  357  GLN A CA  1 
ATOM   2724 C  C   . GLN A 1 356 ? -9.212  -0.473  17.165  1.00 8.93  ?  357  GLN A C   1 
ATOM   2725 O  O   . GLN A 1 356 ? -9.690  -1.515  17.642  1.00 10.35 ?  357  GLN A O   1 
ATOM   2726 C  CB  A GLN A 1 356 ? -9.346  -0.439  14.634  0.55 9.65  ?  357  GLN A CB  1 
ATOM   2727 C  CB  B GLN A 1 356 ? -9.363  -0.523  14.665  0.45 9.69  ?  357  GLN A CB  1 
ATOM   2728 C  CG  A GLN A 1 356 ? -10.015 -1.750  14.278  0.55 7.92  ?  357  GLN A CG  1 
ATOM   2729 C  CG  B GLN A 1 356 ? -10.405 -0.644  13.573  0.45 13.78 ?  357  GLN A CG  1 
ATOM   2730 C  CD  A GLN A 1 356 ? -11.490 -1.624  13.921  0.55 13.72 ?  357  GLN A CD  1 
ATOM   2731 C  CD  B GLN A 1 356 ? -11.591 -1.499  13.981  0.45 13.79 ?  357  GLN A CD  1 
ATOM   2732 O  OE1 A GLN A 1 356 ? -12.209 -0.775  14.453  0.55 13.62 ?  357  GLN A OE1 1 
ATOM   2733 O  OE1 B GLN A 1 356 ? -12.438 -1.072  14.767  0.45 11.84 ?  357  GLN A OE1 1 
ATOM   2734 N  NE2 A GLN A 1 356 ? -11.954 -2.495  13.029  0.55 11.35 ?  357  GLN A NE2 1 
ATOM   2735 N  NE2 B GLN A 1 356 ? -11.672 -2.706  13.429  0.45 10.69 ?  357  GLN A NE2 1 
ATOM   2736 N  N   . LEU A 1 357 ? -8.130  0.118   17.676  1.00 8.65  ?  358  LEU A N   1 
ATOM   2737 C  CA  . LEU A 1 357 ? -7.592  -0.364  18.939  1.00 9.19  ?  358  LEU A CA  1 
ATOM   2738 C  C   . LEU A 1 357 ? -8.554  -0.051  20.078  1.00 9.18  ?  358  LEU A C   1 
ATOM   2739 O  O   . LEU A 1 357 ? -8.684  -0.840  21.018  1.00 9.52  ?  358  LEU A O   1 
ATOM   2740 C  CB  . LEU A 1 357 ? -6.199  0.223   19.177  1.00 10.86 ?  358  LEU A CB  1 
ATOM   2741 C  CG  . LEU A 1 357 ? -5.323  -0.506  20.201  1.00 13.93 ?  358  LEU A CG  1 
ATOM   2742 C  CD1 . LEU A 1 357 ? -5.467  -2.010  20.056  1.00 15.05 ?  358  LEU A CD1 1 
ATOM   2743 C  CD2 . LEU A 1 357 ? -3.862  -0.102  20.078  1.00 15.99 ?  358  LEU A CD2 1 
ATOM   2744 N  N   . GLU A 1 358 ? -9.262  1.077   19.990  1.00 8.62  ?  359  GLU A N   1 
ATOM   2745 C  CA  . GLU A 1 358 ? -10.290 1.397   20.969  1.00 7.90  ?  359  GLU A CA  1 
ATOM   2746 C  C   . GLU A 1 358 ? -11.411 0.362   20.940  1.00 8.34  ?  359  GLU A C   1 
ATOM   2747 O  O   . GLU A 1 358 ? -11.927 -0.039  21.990  1.00 8.51  ?  359  GLU A O   1 
ATOM   2748 C  CB  . GLU A 1 358 ? -10.803 2.823   20.719  1.00 9.24  ?  359  GLU A CB  1 
ATOM   2749 C  CG  . GLU A 1 358 ? -11.941 3.223   21.640  1.00 10.89 ?  359  GLU A CG  1 
ATOM   2750 C  CD  . GLU A 1 358 ? -12.410 4.656   21.436  1.00 10.84 ?  359  GLU A CD  1 
ATOM   2751 O  OE1 . GLU A 1 358 ? -11.880 5.352   20.543  1.00 12.44 ?  359  GLU A OE1 1 
ATOM   2752 O  OE2 . GLU A 1 358 ? -13.298 5.093   22.193  1.00 12.14 -1 359  GLU A OE2 1 
ATOM   2753 N  N   . GLU A 1 359 ? -11.765 -0.123  19.746  1.00 7.40  ?  360  GLU A N   1 
ATOM   2754 C  CA  . GLU A 1 359 ? -12.772 -1.177  19.657  1.00 8.78  ?  360  GLU A CA  1 
ATOM   2755 C  C   . GLU A 1 359 ? -12.237 -2.501  20.197  1.00 9.01  ?  360  GLU A C   1 
ATOM   2756 O  O   . GLU A 1 359 ? -12.972 -3.240  20.866  1.00 8.49  ?  360  GLU A O   1 
ATOM   2757 C  CB  . GLU A 1 359 ? -13.243 -1.320  18.210  1.00 8.45  ?  360  GLU A CB  1 
ATOM   2758 C  CG  . GLU A 1 359 ? -13.965 -0.085  17.666  1.00 8.04  ?  360  GLU A CG  1 
ATOM   2759 C  CD  . GLU A 1 359 ? -15.279 0.206   18.334  1.00 9.64  ?  360  GLU A CD  1 
ATOM   2760 O  OE1 . GLU A 1 359 ? -15.798 1.337   18.164  1.00 10.34 ?  360  GLU A OE1 1 
ATOM   2761 O  OE2 . GLU A 1 359 ? -15.831 -0.674  19.024  1.00 15.46 -1 360  GLU A OE2 1 
ATOM   2762 N  N   . LEU A 1 360 ? -10.966 -2.818  19.925  1.00 7.72  ?  361  LEU A N   1 
ATOM   2763 C  CA  . LEU A 1 360 ? -10.382 -4.022  20.511  1.00 7.69  ?  361  LEU A CA  1 
ATOM   2764 C  C   . LEU A 1 360 ? -10.359 -3.925  22.034  1.00 8.17  ?  361  LEU A C   1 
ATOM   2765 O  O   . LEU A 1 360 ? -10.622 -4.914  22.722  1.00 8.38  ?  361  LEU A O   1 
ATOM   2766 C  CB  . LEU A 1 360 ? -8.984  -4.267  19.937  1.00 7.68  ?  361  LEU A CB  1 
ATOM   2767 C  CG  . LEU A 1 360 ? -8.239  -5.489  20.479  1.00 8.92  ?  361  LEU A CG  1 
ATOM   2768 C  CD1 . LEU A 1 360 ? -9.010  -6.787  20.191  1.00 9.44  ?  361  LEU A CD1 1 
ATOM   2769 C  CD2 . LEU A 1 360 ? -6.851  -5.546  19.912  1.00 11.07 ?  361  LEU A CD2 1 
ATOM   2770 N  N   . ALA A 1 361 ? -10.068 -2.735  22.582  1.00 8.43  ?  362  ALA A N   1 
ATOM   2771 C  CA  . ALA A 1 361 ? -10.118 -2.548  24.034  1.00 8.42  ?  362  ALA A CA  1 
ATOM   2772 C  C   . ALA A 1 361 ? -11.513 -2.833  24.586  1.00 8.66  ?  362  ALA A C   1 
ATOM   2773 O  O   . ALA A 1 361 ? -11.655 -3.444  25.658  1.00 8.45  ?  362  ALA A O   1 
ATOM   2774 C  CB  . ALA A 1 361 ? -9.692  -1.118  24.377  1.00 8.06  ?  362  ALA A CB  1 
ATOM   2775 N  N   . LYS A 1 362 ? -12.556 -2.395  23.869  1.00 8.22  ?  363  LYS A N   1 
ATOM   2776 C  CA  . LYS A 1 362 ? -13.929 -2.686  24.276  1.00 7.40  ?  363  LYS A CA  1 
ATOM   2777 C  C   . LYS A 1 362 ? -14.175 -4.193  24.306  1.00 8.59  ?  363  LYS A C   1 
ATOM   2778 O  O   . LYS A 1 362 ? -14.777 -4.710  25.255  1.00 8.95  ?  363  LYS A O   1 
ATOM   2779 C  CB  . LYS A 1 362 ? -14.912 -1.993  23.329  1.00 10.08 ?  363  LYS A CB  1 
ATOM   2780 C  CG  . LYS A 1 362 ? -16.378 -2.261  23.633  1.00 11.68 ?  363  LYS A CG  1 
ATOM   2781 C  CD  . LYS A 1 362 ? -17.298 -1.346  22.844  1.00 14.19 ?  363  LYS A CD  1 
ATOM   2782 C  CE  . LYS A 1 362 ? -17.501 -1.849  21.440  1.00 13.24 ?  363  LYS A CE  1 
ATOM   2783 N  NZ  . LYS A 1 362 ? -18.480 -0.968  20.721  1.00 14.60 ?  363  LYS A NZ  1 
ATOM   2784 N  N   . VAL A 1 363 ? -13.700 -4.913  23.279  1.00 8.31  ?  364  VAL A N   1 
ATOM   2785 C  CA  . VAL A 1 363 ? -13.823 -6.371  23.270  1.00 7.77  ?  364  VAL A CA  1 
ATOM   2786 C  C   . VAL A 1 363 ? -13.165 -6.956  24.511  1.00 8.45  ?  364  VAL A C   1 
ATOM   2787 O  O   . VAL A 1 363 ? -13.761 -7.775  25.222  1.00 8.67  ?  364  VAL A O   1 
ATOM   2788 C  CB  . VAL A 1 363 ? -13.218 -6.969  21.983  1.00 8.12  ?  364  VAL A CB  1 
ATOM   2789 C  CG1 . VAL A 1 363 ? -13.118 -8.494  22.096  1.00 7.68  ?  364  VAL A CG1 1 
ATOM   2790 C  CG2 . VAL A 1 363 ? -14.050 -6.578  20.766  1.00 8.13  ?  364  VAL A CG2 1 
ATOM   2791 N  N   . ARG A 1 364 ? -11.928 -6.543  24.785  1.00 8.05  ?  365  ARG A N   1 
ATOM   2792 C  CA  . ARG A 1 364 ? -11.140 -7.179  25.837  1.00 8.88  ?  365  ARG A CA  1 
ATOM   2793 C  C   . ARG A 1 364 ? -11.622 -6.825  27.247  1.00 8.93  ?  365  ARG A C   1 
ATOM   2794 O  O   . ARG A 1 364 ? -11.288 -7.542  28.195  1.00 10.41 ?  365  ARG A O   1 
ATOM   2795 C  CB  . ARG A 1 364 ? -9.656  -6.883  25.617  1.00 9.98  ?  365  ARG A CB  1 
ATOM   2796 C  CG  . ARG A 1 364 ? -9.038  -7.554  24.347  1.00 9.38  ?  365  ARG A CG  1 
ATOM   2797 C  CD  . ARG A 1 364 ? -9.391  -9.061  24.237  1.00 8.10  ?  365  ARG A CD  1 
ATOM   2798 N  NE  . ARG A 1 364 ? -9.103  -9.750  25.503  1.00 8.55  ?  365  ARG A NE  1 
ATOM   2799 C  CZ  . ARG A 1 364 ? -7.898  -9.904  26.036  1.00 9.02  ?  365  ARG A CZ  1 
ATOM   2800 N  NH1 . ARG A 1 364 ? -6.804  -9.533  25.377  1.00 10.08 ?  365  ARG A NH1 1 
ATOM   2801 N  NH2 . ARG A 1 364 ? -7.776  -10.489 27.230  1.00 10.63 ?  365  ARG A NH2 1 
ATOM   2802 N  N   . ARG A 1 365 ? -12.419 -5.762  27.413  1.00 8.23  ?  366  ARG A N   1 
ATOM   2803 C  CA  . ARG A 1 365 ? -13.041 -5.532  28.720  1.00 9.56  ?  366  ARG A CA  1 
ATOM   2804 C  C   . ARG A 1 365 ? -14.073 -6.607  29.032  1.00 12.04 ?  366  ARG A C   1 
ATOM   2805 O  O   . ARG A 1 365 ? -14.347 -6.881  30.207  1.00 13.64 ?  366  ARG A O   1 
ATOM   2806 C  CB  . ARG A 1 365 ? -13.687 -4.143  28.781  1.00 10.52 ?  366  ARG A CB  1 
ATOM   2807 C  CG  . ARG A 1 365 ? -12.683 -3.015  28.832  1.00 10.60 ?  366  ARG A CG  1 
ATOM   2808 C  CD  . ARG A 1 365 ? -13.289 -1.689  29.306  1.00 13.22 ?  366  ARG A CD  1 
ATOM   2809 N  NE  . ARG A 1 365 ? -14.293 -1.194  28.366  1.00 12.12 ?  366  ARG A NE  1 
ATOM   2810 C  CZ  . ARG A 1 365 ? -14.001 -0.503  27.269  1.00 11.70 ?  366  ARG A CZ  1 
ATOM   2811 N  NH1 . ARG A 1 365 ? -12.739 -0.240  26.971  1.00 11.72 ?  366  ARG A NH1 1 
ATOM   2812 N  NH2 . ARG A 1 365 ? -14.976 -0.083  26.473  1.00 11.43 ?  366  ARG A NH2 1 
ATOM   2813 N  N   . LYS A 1 366 ? -14.640 -7.236  28.001  1.00 9.81  ?  367  LYS A N   1 
ATOM   2814 C  CA  . LYS A 1 366 ? -15.688 -8.233  28.176  1.00 10.11 ?  367  LYS A CA  1 
ATOM   2815 C  C   . LYS A 1 366 ? -15.210 -9.665  28.003  1.00 11.72 ?  367  LYS A C   1 
ATOM   2816 O  O   . LYS A 1 366 ? -15.793 -10.567 28.616  1.00 13.86 ?  367  LYS A O   1 
ATOM   2817 C  CB  . LYS A 1 366 ? -16.829 -7.991  27.181  1.00 11.57 ?  367  LYS A CB  1 
ATOM   2818 C  CG  . LYS A 1 366 ? -18.092 -8.764  27.517  1.00 12.21 ?  367  LYS A CG  1 
ATOM   2819 C  CD  . LYS A 1 366 ? -19.237 -8.391  26.605  1.00 14.26 ?  367  LYS A CD  1 
ATOM   2820 C  CE  . LYS A 1 366 ? -20.531 -8.980  27.137  1.00 15.01 ?  367  LYS A CE  1 
ATOM   2821 N  NZ  . LYS A 1 366 ? -21.668 -8.728  26.217  1.00 16.42 ?  367  LYS A NZ  1 
ATOM   2822 N  N   . ALA A 1 367 ? -14.190 -9.918  27.185  1.00 9.07  ?  368  ALA A N   1 
ATOM   2823 C  CA  . ALA A 1 367 ? -13.926 -11.290 26.781  1.00 8.86  ?  368  ALA A CA  1 
ATOM   2824 C  C   . ALA A 1 367 ? -12.450 -11.525 26.517  1.00 8.98  ?  368  ALA A C   1 
ATOM   2825 O  O   . ALA A 1 367 ? -11.723 -10.614 26.111  1.00 9.14  ?  368  ALA A O   1 
ATOM   2826 C  CB  . ALA A 1 367 ? -14.698 -11.605 25.497  1.00 10.55 ?  368  ALA A CB  1 
ATOM   2827 N  N   . ARG A 1 368 ? -12.025 -12.776 26.719  1.00 8.55  ?  369  ARG A N   1 
ATOM   2828 C  CA  . ARG A 1 368 ? -10.771 -13.275 26.164  1.00 8.20  ?  369  ARG A CA  1 
ATOM   2829 C  C   . ARG A 1 368 ? -10.955 -13.515 24.664  1.00 8.22  ?  369  ARG A C   1 
ATOM   2830 O  O   . ARG A 1 368 ? -12.072 -13.719 24.181  1.00 9.21  ?  369  ARG A O   1 
ATOM   2831 C  CB  . ARG A 1 368 ? -10.418 -14.630 26.797  1.00 9.69  ?  369  ARG A CB  1 
ATOM   2832 C  CG  . ARG A 1 368 ? -10.503 -14.628 28.319  1.00 11.48 ?  369  ARG A CG  1 
ATOM   2833 C  CD  . ARG A 1 368 ? -10.178 -16.017 28.844  1.00 10.53 ?  369  ARG A CD  1 
ATOM   2834 N  NE  . ARG A 1 368 ? -10.065 -16.067 30.307  1.00 13.85 ?  369  ARG A NE  1 
ATOM   2835 C  CZ  . ARG A 1 368 ? -8.923  -16.063 30.985  1.00 13.08 ?  369  ARG A CZ  1 
ATOM   2836 N  NH1 . ARG A 1 368 ? -7.776  -15.953 30.348  1.00 13.70 ?  369  ARG A NH1 1 
ATOM   2837 N  NH2 . ARG A 1 368 ? -8.934  -16.136 32.314  1.00 14.44 ?  369  ARG A NH2 1 
ATOM   2838 N  N   . VAL A 1 369 ? -9.847  -13.525 23.925  1.00 8.59  ?  370  VAL A N   1 
ATOM   2839 C  CA  . VAL A 1 369 ? -9.884  -13.814 22.491  1.00 8.52  ?  370  VAL A CA  1 
ATOM   2840 C  C   . VAL A 1 369 ? -8.832  -14.862 22.159  1.00 10.31 ?  370  VAL A C   1 
ATOM   2841 O  O   . VAL A 1 369 ? -7.657  -14.703 22.518  1.00 9.55  ?  370  VAL A O   1 
ATOM   2842 C  CB  . VAL A 1 369 ? -9.643  -12.554 21.636  1.00 7.64  ?  370  VAL A CB  1 
ATOM   2843 C  CG1 . VAL A 1 369 ? -9.511  -12.925 20.146  1.00 9.11  ?  370  VAL A CG1 1 
ATOM   2844 C  CG2 . VAL A 1 369 ? -10.755 -11.547 21.844  1.00 9.40  ?  370  VAL A CG2 1 
ATOM   2845 N  N   . LYS A 1 370 ? -9.249  -15.911 21.448  1.00 9.12  ?  371  LYS A N   1 
ATOM   2846 C  CA  . LYS A 1 370 ? -8.347  -16.877 20.827  1.00 7.71  ?  371  LYS A CA  1 
ATOM   2847 C  C   . LYS A 1 370 ? -8.419  -16.642 19.322  1.00 8.12  ?  371  LYS A C   1 
ATOM   2848 O  O   . LYS A 1 370 ? -9.519  -16.550 18.761  1.00 9.06  ?  371  LYS A O   1 
ATOM   2849 C  CB  . LYS A 1 370 ? -8.766  -18.312 21.163  1.00 9.30  ?  371  LYS A CB  1 
ATOM   2850 C  CG  . LYS A 1 370 ? -8.507  -18.687 22.624  1.00 8.83  ?  371  LYS A CG  1 
ATOM   2851 C  CD  . LYS A 1 370 ? -9.028  -20.095 22.910  1.00 8.81  ?  371  LYS A CD  1 
ATOM   2852 C  CE  . LYS A 1 370 ? -8.866  -20.514 24.376  1.00 12.49 ?  371  LYS A CE  1 
ATOM   2853 N  NZ  . LYS A 1 370 ? -7.443  -20.762 24.764  1.00 13.23 ?  371  LYS A NZ  1 
ATOM   2854 N  N   . PHE A 1 371 ? -7.264  -16.528 18.672  1.00 8.01  ?  372  PHE A N   1 
ATOM   2855 C  CA  A PHE A 1 371 ? -7.186  -16.123 17.271  0.50 7.92  ?  372  PHE A CA  1 
ATOM   2856 C  CA  B PHE A 1 371 ? -7.186  -16.125 17.270  0.50 7.92  ?  372  PHE A CA  1 
ATOM   2857 C  C   . PHE A 1 371 ? -6.506  -17.208 16.447  1.00 8.55  ?  372  PHE A C   1 
ATOM   2858 O  O   . PHE A 1 371 ? -5.387  -17.626 16.764  1.00 9.74  ?  372  PHE A O   1 
ATOM   2859 C  CB  A PHE A 1 371 ? -6.437  -14.789 17.142  0.50 8.19  ?  372  PHE A CB  1 
ATOM   2860 C  CB  B PHE A 1 371 ? -6.436  -14.793 17.127  0.50 8.20  ?  372  PHE A CB  1 
ATOM   2861 C  CG  A PHE A 1 371 ? -6.870  -13.953 15.964  0.50 7.77  ?  372  PHE A CG  1 
ATOM   2862 C  CG  B PHE A 1 371 ? -6.889  -13.960 15.953  0.50 7.77  ?  372  PHE A CG  1 
ATOM   2863 C  CD1 A PHE A 1 371 ? -7.466  -12.712 16.149  0.50 8.02  ?  372  PHE A CD1 1 
ATOM   2864 C  CD1 B PHE A 1 371 ? -7.425  -12.694 16.141  0.50 8.04  ?  372  PHE A CD1 1 
ATOM   2865 C  CD2 A PHE A 1 371 ? -6.637  -14.389 14.669  0.50 8.51  ?  372  PHE A CD2 1 
ATOM   2866 C  CD2 B PHE A 1 371 ? -6.746  -14.434 14.658  0.50 8.60  ?  372  PHE A CD2 1 
ATOM   2867 C  CE1 A PHE A 1 371 ? -7.856  -11.943 15.068  0.50 8.22  ?  372  PHE A CE1 1 
ATOM   2868 C  CE1 B PHE A 1 371 ? -7.833  -11.930 15.063  0.50 8.23  ?  372  PHE A CE1 1 
ATOM   2869 C  CE2 A PHE A 1 371 ? -7.024  -13.626 13.585  0.50 8.24  ?  372  PHE A CE2 1 
ATOM   2870 C  CE2 B PHE A 1 371 ? -7.154  -13.678 13.576  0.50 8.21  ?  372  PHE A CE2 1 
ATOM   2871 C  CZ  A PHE A 1 371 ? -7.634  -12.397 13.786  0.50 8.17  ?  372  PHE A CZ  1 
ATOM   2872 C  CZ  B PHE A 1 371 ? -7.698  -12.420 13.781  0.50 8.16  ?  372  PHE A CZ  1 
ATOM   2873 N  N   . VAL A 1 372 ? -7.179  -17.646 15.384  1.00 8.06  ?  373  VAL A N   1 
ATOM   2874 C  CA  . VAL A 1 372 ? -6.692  -18.708 14.509  1.00 8.06  ?  373  VAL A CA  1 
ATOM   2875 C  C   . VAL A 1 372 ? -6.452  -18.106 13.131  1.00 8.90  ?  373  VAL A C   1 
ATOM   2876 O  O   . VAL A 1 372 ? -7.394  -17.633 12.479  1.00 9.15  ?  373  VAL A O   1 
ATOM   2877 C  CB  . VAL A 1 372 ? -7.693  -19.871 14.442  1.00 7.58  ?  373  VAL A CB  1 
ATOM   2878 C  CG1 . VAL A 1 372 ? -7.176  -20.990 13.540  1.00 9.78  ?  373  VAL A CG1 1 
ATOM   2879 C  CG2 . VAL A 1 372 ? -7.943  -20.425 15.852  1.00 10.37 ?  373  VAL A CG2 1 
ATOM   2880 N  N   . SER A 1 373 ? -5.196  -18.121 12.687  1.00 9.33  ?  374  SER A N   1 
ATOM   2881 C  CA  . SER A 1 373 ? -4.831  -17.559 11.390  1.00 9.40  ?  374  SER A CA  1 
ATOM   2882 C  C   . SER A 1 373 ? -3.452  -18.043 10.980  1.00 11.26 ?  374  SER A C   1 
ATOM   2883 O  O   . SER A 1 373 ? -2.568  -18.209 11.822  1.00 12.45 ?  374  SER A O   1 
ATOM   2884 C  CB  . SER A 1 373 ? -4.762  -16.032 11.479  1.00 8.77  ?  374  SER A CB  1 
ATOM   2885 O  OG  . SER A 1 373 ? -4.405  -15.468 10.219  1.00 9.65  ?  374  SER A OG  1 
ATOM   2886 N  N   . ASP A 1 374 ? -3.263  -18.226 9.672   1.00 12.31 ?  375  ASP A N   1 
ATOM   2887 C  CA  A ASP A 1 374 ? -1.923  -18.441 9.135   0.63 13.91 ?  375  ASP A CA  1 
ATOM   2888 C  CA  B ASP A 1 374 ? -1.942  -18.452 9.096   0.37 13.91 ?  375  ASP A CA  1 
ATOM   2889 C  C   . ASP A 1 374 ? -1.344  -17.205 8.458   1.00 14.29 ?  375  ASP A C   1 
ATOM   2890 O  O   . ASP A 1 374 ? -0.232  -17.270 7.928   1.00 16.57 ?  375  ASP A O   1 
ATOM   2891 C  CB  A ASP A 1 374 ? -1.834  -19.674 8.208   0.63 17.38 ?  375  ASP A CB  1 
ATOM   2892 C  CB  B ASP A 1 374 ? -1.983  -19.578 8.056   0.37 17.41 ?  375  ASP A CB  1 
ATOM   2893 C  CG  A ASP A 1 374 ? -3.048  -19.849 7.303   0.63 18.53 ?  375  ASP A CG  1 
ATOM   2894 C  CG  B ASP A 1 374 ? -2.163  -20.941 8.679   0.37 14.99 ?  375  ASP A CG  1 
ATOM   2895 O  OD1 A ASP A 1 374 ? -3.322  -21.005 6.917   0.63 22.27 ?  375  ASP A OD1 1 
ATOM   2896 O  OD1 B ASP A 1 374 ? -1.816  -21.103 9.868   0.37 16.20 ?  375  ASP A OD1 1 
ATOM   2897 O  OD2 A ASP A 1 374 ? -3.713  -18.856 6.950   0.63 18.89 -1 375  ASP A OD2 1 
ATOM   2898 O  OD2 B ASP A 1 374 ? -2.635  -21.854 7.973   0.37 21.78 -1 375  ASP A OD2 1 
ATOM   2899 N  N   . GLY A 1 375 ? -2.050  -16.073 8.482   1.00 12.30 ?  376  GLY A N   1 
ATOM   2900 C  CA  . GLY A 1 375 ? -1.520  -14.904 7.801   1.00 13.06 ?  376  GLY A CA  1 
ATOM   2901 C  C   . GLY A 1 375 ? -0.474  -14.137 8.575   1.00 15.50 ?  376  GLY A C   1 
ATOM   2902 O  O   . GLY A 1 375 ? 0.262   -13.338 7.987   1.00 17.26 ?  376  GLY A O   1 
ATOM   2903 N  N   . VAL A 1 376 ? -0.402  -14.352 9.883   1.00 14.53 ?  377  VAL A N   1 
ATOM   2904 C  CA  . VAL A 1 376 ? 0.483   -13.619 10.778  1.00 18.76 ?  377  VAL A CA  1 
ATOM   2905 C  C   . VAL A 1 376 ? 1.044   -14.654 11.749  1.00 21.50 ?  377  VAL A C   1 
ATOM   2906 O  O   . VAL A 1 376 ? 0.276   -15.479 12.270  1.00 21.10 ?  377  VAL A O   1 
ATOM   2907 C  CB  . VAL A 1 376 ? -0.314  -12.510 11.489  1.00 19.24 ?  377  VAL A CB  1 
ATOM   2908 C  CG1 . VAL A 1 376 ? 0.384   -12.005 12.724  1.00 23.46 ?  377  VAL A CG1 1 
ATOM   2909 C  CG2 . VAL A 1 376 ? -0.595  -11.362 10.516  1.00 21.72 ?  377  VAL A CG2 1 
ATOM   2910 N  N   . PRO A 1 377 ? 2.353   -14.684 12.001  1.00 16.60 ?  378  PRO A N   1 
ATOM   2911 C  CA  . PRO A 1 377 ? 2.896   -15.673 12.943  1.00 15.91 ?  378  PRO A CA  1 
ATOM   2912 C  C   . PRO A 1 377 ? 2.341   -15.477 14.346  1.00 13.50 ?  378  PRO A C   1 
ATOM   2913 O  O   . PRO A 1 377 ? 1.920   -14.385 14.742  1.00 14.39 ?  378  PRO A O   1 
ATOM   2914 C  CB  . PRO A 1 377 ? 4.410   -15.425 12.911  1.00 20.42 ?  378  PRO A CB  1 
ATOM   2915 C  CG  . PRO A 1 377 ? 4.653   -14.613 11.666  1.00 23.61 ?  378  PRO A CG  1 
ATOM   2916 C  CD  . PRO A 1 377 ? 3.403   -13.812 11.452  1.00 17.80 ?  378  PRO A CD  1 
ATOM   2917 N  N   . ALA A 1 378 ? 2.345   -16.582 15.099  1.00 13.45 ?  379  ALA A N   1 
ATOM   2918 C  CA  . ALA A 1 378 ? 1.799   -16.581 16.452  1.00 16.31 ?  379  ALA A CA  1 
ATOM   2919 C  C   . ALA A 1 378 ? 2.455   -15.515 17.317  1.00 12.92 ?  379  ALA A C   1 
ATOM   2920 O  O   . ALA A 1 378 ? 1.773   -14.825 18.088  1.00 15.49 ?  379  ALA A O   1 
ATOM   2921 C  CB  . ALA A 1 378 ? 1.979   -17.963 17.082  1.00 12.79 ?  379  ALA A CB  1 
ATOM   2922 N  N   . ALA A 1 379 ? 3.776   -15.358 17.206  1.00 13.29 ?  380  ALA A N   1 
ATOM   2923 C  CA  . ALA A 1 379 ? 4.460   -14.377 18.047  1.00 16.40 ?  380  ALA A CA  1 
ATOM   2924 C  C   . ALA A 1 379 ? 3.976   -12.963 17.759  1.00 17.60 ?  380  ALA A C   1 
ATOM   2925 O  O   . ALA A 1 379 ? 3.878   -12.139 18.674  1.00 20.64 ?  380  ALA A O   1 
ATOM   2926 C  CB  . ALA A 1 379 ? 5.975   -14.481 17.878  1.00 17.57 ?  380  ALA A CB  1 
ATOM   2927 N  N   . VAL A 1 380 ? 3.633   -12.671 16.508  1.00 14.09 ?  381  VAL A N   1 
ATOM   2928 C  CA  . VAL A 1 380 ? 3.115   -11.346 16.181  1.00 15.90 ?  381  VAL A CA  1 
ATOM   2929 C  C   . VAL A 1 380 ? 1.707   -11.158 16.745  1.00 15.86 ?  381  VAL A C   1 
ATOM   2930 O  O   . VAL A 1 380 ? 1.400   -10.128 17.358  1.00 17.96 ?  381  VAL A O   1 
ATOM   2931 C  CB  . VAL A 1 380 ? 3.183   -11.105 14.665  1.00 19.51 ?  381  VAL A CB  1 
ATOM   2932 C  CG1 . VAL A 1 380 ? 2.564   -9.778  14.313  1.00 18.05 ?  381  VAL A CG1 1 
ATOM   2933 C  CG2 . VAL A 1 380 ? 4.624   -11.143 14.194  1.00 20.99 ?  381  VAL A CG2 1 
ATOM   2934 N  N   . LEU A 1 381 ? 0.830   -12.150 16.559  1.00 13.76 ?  382  LEU A N   1 
ATOM   2935 C  CA  . LEU A 1 381 ? -0.526  -12.045 17.093  1.00 13.89 ?  382  LEU A CA  1 
ATOM   2936 C  C   . LEU A 1 381 ? -0.521  -11.900 18.607  1.00 16.39 ?  382  LEU A C   1 
ATOM   2937 O  O   . LEU A 1 381 ? -1.372  -11.206 19.180  1.00 15.36 ?  382  LEU A O   1 
ATOM   2938 C  CB  . LEU A 1 381 ? -1.326  -13.293 16.725  1.00 15.94 ?  382  LEU A CB  1 
ATOM   2939 C  CG  . LEU A 1 381 ? -1.983  -13.317 15.350  1.00 17.18 ?  382  LEU A CG  1 
ATOM   2940 C  CD1 . LEU A 1 381 ? -2.780  -14.607 15.206  1.00 16.79 ?  382  LEU A CD1 1 
ATOM   2941 C  CD2 . LEU A 1 381 ? -2.868  -12.092 15.142  1.00 16.48 ?  382  LEU A CD2 1 
ATOM   2942 N  N   . SER A 1 382 ? 0.415   -12.570 19.280  1.00 15.52 ?  383  SER A N   1 
ATOM   2943 C  CA  A SER A 1 382 ? 0.436   -12.506 20.734  0.52 15.26 ?  383  SER A CA  1 
ATOM   2944 C  CA  B SER A 1 382 ? 0.481   -12.515 20.736  0.48 15.26 ?  383  SER A CA  1 
ATOM   2945 C  C   . SER A 1 382 ? 0.707   -11.098 21.245  1.00 16.79 ?  383  SER A C   1 
ATOM   2946 O  O   . SER A 1 382 ? 0.339   -10.784 22.383  1.00 18.27 ?  383  SER A O   1 
ATOM   2947 C  CB  A SER A 1 382 ? 1.429   -13.518 21.307  0.52 17.31 ?  383  SER A CB  1 
ATOM   2948 C  CB  B SER A 1 382 ? 1.594   -13.433 21.237  0.48 17.53 ?  383  SER A CB  1 
ATOM   2949 O  OG  A SER A 1 382 ? 2.762   -13.087 21.113  0.52 20.31 ?  383  SER A OG  1 
ATOM   2950 O  OG  B SER A 1 382 ? 1.093   -14.714 21.563  0.48 20.75 ?  383  SER A OG  1 
ATOM   2951 N  N   . ARG A 1 383 ? 1.324   -10.236 20.434  1.00 14.28 ?  384  ARG A N   1 
ATOM   2952 C  CA  . ARG A 1 383 ? 1.512   -8.844  20.824  1.00 13.23 ?  384  ARG A CA  1 
ATOM   2953 C  C   . ARG A 1 383 ? 0.300   -7.971  20.530  1.00 13.42 ?  384  ARG A C   1 
ATOM   2954 O  O   . ARG A 1 383 ? 0.350   -6.766  20.800  1.00 15.88 ?  384  ARG A O   1 
ATOM   2955 C  CB  . ARG A 1 383 ? 2.738   -8.221  20.147  1.00 17.14 ?  384  ARG A CB  1 
ATOM   2956 C  CG  . ARG A 1 383 ? 4.061   -8.870  20.492  1.00 22.39 ?  384  ARG A CG  1 
ATOM   2957 C  CD  . ARG A 1 383 ? 5.095   -8.484  19.459  1.00 28.87 ?  384  ARG A CD  1 
ATOM   2958 N  NE  . ARG A 1 383 ? 6.010   -9.569  19.130  1.00 45.65 ?  384  ARG A NE  1 
ATOM   2959 C  CZ  . ARG A 1 383 ? 6.592   -9.698  17.944  1.00 35.61 ?  384  ARG A CZ  1 
ATOM   2960 N  NH1 . ARG A 1 383 ? 7.417   -10.707 17.712  1.00 40.55 ?  384  ARG A NH1 1 
ATOM   2961 N  NH2 . ARG A 1 383 ? 6.344   -8.811  16.988  1.00 39.42 ?  384  ARG A NH2 1 
ATOM   2962 N  N   . CYS A 1 384 ? -0.778  -8.536  19.989  1.00 12.16 ?  385  CYS A N   1 
ATOM   2963 C  CA  . CYS A 1 384 ? -1.959  -7.769  19.622  1.00 11.53 ?  385  CYS A CA  1 
ATOM   2964 C  C   . CYS A 1 384 ? -3.149  -8.061  20.521  1.00 9.65  ?  385  CYS A C   1 
ATOM   2965 O  O   . CYS A 1 384 ? -4.292  -7.870  20.109  1.00 10.30 ?  385  CYS A O   1 
ATOM   2966 C  CB  . CYS A 1 384 ? -2.325  -7.998  18.156  1.00 11.32 ?  385  CYS A CB  1 
ATOM   2967 S  SG  . CYS A 1 384 ? -1.025  -7.525  16.985  1.00 16.16 ?  385  CYS A SG  1 
ATOM   2968 N  N   . HIS A 1 385 ? -2.904  -8.513  21.747  1.00 9.46  ?  386  HIS A N   1 
ATOM   2969 C  CA  . HIS A 1 385 ? -3.956  -8.668  22.748  1.00 9.93  ?  386  HIS A CA  1 
ATOM   2970 C  C   . HIS A 1 385 ? -4.972  -9.729  22.357  1.00 11.64 ?  386  HIS A C   1 
ATOM   2971 O  O   . HIS A 1 385 ? -6.153  -9.616  22.665  1.00 10.67 ?  386  HIS A O   1 
ATOM   2972 C  CB  . HIS A 1 385 ? -4.609  -7.338  23.117  1.00 11.50 ?  386  HIS A CB  1 
ATOM   2973 C  CG  . HIS A 1 385 ? -3.612  -6.347  23.598  1.00 11.48 ?  386  HIS A CG  1 
ATOM   2974 N  ND1 . HIS A 1 385 ? -3.110  -6.369  24.882  1.00 11.99 ?  386  HIS A ND1 1 
ATOM   2975 C  CD2 . HIS A 1 385 ? -2.938  -5.376  22.940  1.00 12.95 ?  386  HIS A CD2 1 
ATOM   2976 C  CE1 . HIS A 1 385 ? -2.212  -5.406  25.010  1.00 13.68 ?  386  HIS A CE1 1 
ATOM   2977 N  NE2 . HIS A 1 385 ? -2.081  -4.799  23.844  1.00 13.55 ?  386  HIS A NE2 1 
ATOM   2978 N  N   . VAL A 1 386 ? -4.488  -10.771 21.682  1.00 9.92  ?  387  VAL A N   1 
ATOM   2979 C  CA  . VAL A 1 386 ? -5.241  -11.994 21.447  1.00 9.75  ?  387  VAL A CA  1 
ATOM   2980 C  C   . VAL A 1 386 ? -4.296  -13.157 21.721  1.00 10.14 ?  387  VAL A C   1 
ATOM   2981 O  O   . VAL A 1 386 ? -3.070  -13.004 21.714  1.00 12.23 ?  387  VAL A O   1 
ATOM   2982 C  CB  . VAL A 1 386 ? -5.802  -12.067 20.001  1.00 8.33  ?  387  VAL A CB  1 
ATOM   2983 C  CG1 . VAL A 1 386 ? -6.681  -10.849 19.696  1.00 9.62  ?  387  VAL A CG1 1 
ATOM   2984 C  CG2 . VAL A 1 386 ? -4.660  -12.192 18.969  1.00 10.17 ?  387  VAL A CG2 1 
ATOM   2985 N  N   . GLU A 1 387 ? -4.878  -14.332 21.981  1.00 9.18  ?  388  GLU A N   1 
ATOM   2986 C  CA  . GLU A 1 387 ? -4.085  -15.539 22.174  1.00 10.08 ?  388  GLU A CA  1 
ATOM   2987 C  C   . GLU A 1 387 ? -4.084  -16.333 20.877  1.00 10.49 ?  388  GLU A C   1 
ATOM   2988 O  O   . GLU A 1 387 ? -5.135  -16.862 20.492  1.00 9.78  ?  388  GLU A O   1 
ATOM   2989 C  CB  . GLU A 1 387 ? -4.679  -16.386 23.303  1.00 10.80 ?  388  GLU A CB  1 
ATOM   2990 C  CG  . GLU A 1 387 ? -3.869  -17.660 23.569  1.00 10.50 ?  388  GLU A CG  1 
ATOM   2991 C  CD  . GLU A 1 387 ? -4.627  -18.713 24.359  1.00 15.73 ?  388  GLU A CD  1 
ATOM   2992 O  OE1 . GLU A 1 387 ? -5.788  -18.478 24.750  1.00 13.62 ?  388  GLU A OE1 1 
ATOM   2993 O  OE2 . GLU A 1 387 ? -4.041  -19.791 24.600  1.00 18.21 -1 388  GLU A OE2 1 
ATOM   2994 N  N   . PRO A 1 388 ? -2.953  -16.480 20.190  1.00 10.50 ?  389  PRO A N   1 
ATOM   2995 C  CA  . PRO A 1 388 ? -2.943  -17.312 18.978  1.00 10.17 ?  389  PRO A CA  1 
ATOM   2996 C  C   . PRO A 1 388 ? -3.094  -18.774 19.365  1.00 8.99  ?  389  PRO A C   1 
ATOM   2997 O  O   . PRO A 1 388 ? -2.441  -19.250 20.297  1.00 12.46 ?  389  PRO A O   1 
ATOM   2998 C  CB  . PRO A 1 388 ? -1.563  -17.047 18.366  1.00 11.16 ?  389  PRO A CB  1 
ATOM   2999 C  CG  . PRO A 1 388 ? -0.709  -16.612 19.529  1.00 17.04 ?  389  PRO A CG  1 
ATOM   3000 C  CD  . PRO A 1 388 ? -1.625  -15.938 20.522  1.00 10.83 ?  389  PRO A CD  1 
ATOM   3001 N  N   . VAL A 1 389 ? -3.973  -19.482 18.660  1.00 8.90  ?  390  VAL A N   1 
ATOM   3002 C  CA  . VAL A 1 389 ? -4.171  -20.914 18.865  1.00 9.72  ?  390  VAL A CA  1 
ATOM   3003 C  C   . VAL A 1 389 ? -4.139  -21.596 17.504  1.00 9.91  ?  390  VAL A C   1 
ATOM   3004 O  O   . VAL A 1 389 ? -4.614  -21.041 16.506  1.00 10.65 ?  390  VAL A O   1 
ATOM   3005 C  CB  . VAL A 1 389 ? -5.486  -21.210 19.630  1.00 8.73  ?  390  VAL A CB  1 
ATOM   3006 C  CG1 . VAL A 1 389 ? -5.639  -22.706 19.895  1.00 9.45  ?  390  VAL A CG1 1 
ATOM   3007 C  CG2 . VAL A 1 389 ? -5.537  -20.440 20.958  1.00 11.55 ?  390  VAL A CG2 1 
ATOM   3008 N  N   . ALA A 1 390 ? -3.588  -22.812 17.462  1.00 9.56  ?  391  ALA A N   1 
ATOM   3009 C  CA  . ALA A 1 390 ? -3.249  -23.421 16.178  1.00 10.85 ?  391  ALA A CA  1 
ATOM   3010 C  C   . ALA A 1 390 ? -4.484  -23.745 15.349  1.00 13.36 ?  391  ALA A C   1 
ATOM   3011 O  O   . ALA A 1 390 ? -4.438  -23.660 14.118  1.00 13.38 ?  391  ALA A O   1 
ATOM   3012 C  CB  . ALA A 1 390 ? -2.415  -24.687 16.388  1.00 13.10 ?  391  ALA A CB  1 
ATOM   3013 N  N   . THR A 1 391 ? -5.574  -24.179 15.989  1.00 10.37 ?  392  THR A N   1 
ATOM   3014 C  CA  . THR A 1 391 ? -6.799  -24.549 15.282  1.00 8.78  ?  392  THR A CA  1 
ATOM   3015 C  C   . THR A 1 391 ? -8.018  -24.077 16.069  1.00 8.24  ?  392  THR A C   1 
ATOM   3016 O  O   . THR A 1 391 ? -7.965  -23.894 17.292  1.00 8.28  ?  392  THR A O   1 
ATOM   3017 C  CB  . THR A 1 391 ? -6.905  -26.068 14.997  1.00 8.93  ?  392  THR A CB  1 
ATOM   3018 O  OG1 . THR A 1 391 ? -7.353  -26.748 16.182  1.00 10.56 ?  392  THR A OG1 1 
ATOM   3019 C  CG2 . THR A 1 391 ? -5.568  -26.670 14.525  1.00 10.39 ?  392  THR A CG2 1 
ATOM   3020 N  N   . VAL A 1 392 ? -9.129  -23.881 15.345  1.00 7.87  ?  393  VAL A N   1 
ATOM   3021 C  CA  . VAL A 1 392 ? -10.391 -23.528 15.996  1.00 8.26  ?  393  VAL A CA  1 
ATOM   3022 C  C   . VAL A 1 392 ? -10.843 -24.652 16.918  1.00 9.08  ?  393  VAL A C   1 
ATOM   3023 O  O   . VAL A 1 392 ? -11.311 -24.412 18.038  1.00 9.25  ?  393  VAL A O   1 
ATOM   3024 C  CB  . VAL A 1 392 ? -11.477 -23.182 14.960  1.00 9.03  ?  393  VAL A CB  1 
ATOM   3025 C  CG1 . VAL A 1 392 ? -12.839 -22.957 15.637  1.00 10.28 ?  393  VAL A CG1 1 
ATOM   3026 C  CG2 . VAL A 1 392 ? -11.073 -21.985 14.122  1.00 9.07  ?  393  VAL A CG2 1 
ATOM   3027 N  N   . GLU A 1 393 ? -10.716 -25.899 16.456  1.00 8.91  ?  394  GLU A N   1 
ATOM   3028 C  CA  A GLU A 1 393 ? -11.132 -27.030 17.279  0.37 10.22 ?  394  GLU A CA  1 
ATOM   3029 C  CA  B GLU A 1 393 ? -11.121 -27.042 17.270  0.63 10.24 ?  394  GLU A CA  1 
ATOM   3030 C  C   . GLU A 1 393 ? -10.334 -27.098 18.571  1.00 9.71  ?  394  GLU A C   1 
ATOM   3031 O  O   . GLU A 1 393 ? -10.896 -27.374 19.639  1.00 9.85  ?  394  GLU A O   1 
ATOM   3032 C  CB  A GLU A 1 393 ? -11.024 -28.322 16.472  0.37 9.84  ?  394  GLU A CB  1 
ATOM   3033 C  CB  B GLU A 1 393 ? -10.929 -28.340 16.479  0.63 9.86  ?  394  GLU A CB  1 
ATOM   3034 C  CG  A GLU A 1 393 ? -11.799 -28.211 15.194  0.37 10.77 ?  394  GLU A CG  1 
ATOM   3035 C  CG  B GLU A 1 393 ? -11.453 -29.574 17.214  0.63 9.79  ?  394  GLU A CG  1 
ATOM   3036 C  CD  A GLU A 1 393 ? -11.840 -29.465 14.365  0.37 14.38 ?  394  GLU A CD  1 
ATOM   3037 C  CD  B GLU A 1 393 ? -11.617 -30.808 16.338  0.63 10.91 ?  394  GLU A CD  1 
ATOM   3038 O  OE1 A GLU A 1 393 ? -12.050 -29.275 13.151  0.37 15.31 ?  394  GLU A OE1 1 
ATOM   3039 O  OE1 B GLU A 1 393 ? -11.480 -30.736 15.103  0.63 10.27 ?  394  GLU A OE1 1 
ATOM   3040 O  OE2 A GLU A 1 393 ? -11.668 -30.593 14.888  0.37 12.35 -1 394  GLU A OE2 1 
ATOM   3041 O  OE2 B GLU A 1 393 ? -11.867 -31.881 16.914  0.63 12.47 -1 394  GLU A OE2 1 
ATOM   3042 N  N   . LEU A 1 394 ? -9.029  -26.836 18.503  1.00 9.17  ?  395  LEU A N   1 
ATOM   3043 C  CA  . LEU A 1 394 ? -8.228  -26.806 19.722  1.00 9.70  ?  395  LEU A CA  1 
ATOM   3044 C  C   . LEU A 1 394 ? -8.623  -25.636 20.616  1.00 9.24  ?  395  LEU A C   1 
ATOM   3045 O  O   . LEU A 1 394 ? -8.743  -25.788 21.842  1.00 9.94  ?  395  LEU A O   1 
ATOM   3046 C  CB  . LEU A 1 394 ? -6.742  -26.764 19.375  1.00 12.13 ?  395  LEU A CB  1 
ATOM   3047 C  CG  . LEU A 1 394 ? -5.778  -26.575 20.545  1.00 10.66 ?  395  LEU A CG  1 
ATOM   3048 C  CD1 . LEU A 1 394 ? -5.859  -27.741 21.522  1.00 13.95 ?  395  LEU A CD1 1 
ATOM   3049 C  CD2 . LEU A 1 394 ? -4.366  -26.424 20.028  1.00 13.03 ?  395  LEU A CD2 1 
ATOM   3050 N  N   . ALA A 1 395 ? -8.834  -24.462 20.019  1.00 9.43  ?  396  ALA A N   1 
ATOM   3051 C  CA  . ALA A 1 395 ? -9.207  -23.285 20.796  1.00 9.82  ?  396  ALA A CA  1 
ATOM   3052 C  C   . ALA A 1 395 ? -10.508 -23.523 21.552  1.00 8.64  ?  396  ALA A C   1 
ATOM   3053 O  O   . ALA A 1 395 ? -10.632 -23.147 22.725  1.00 9.59  ?  396  ALA A O   1 
ATOM   3054 C  CB  . ALA A 1 395 ? -9.354  -22.089 19.859  1.00 9.29  ?  396  ALA A CB  1 
ATOM   3055 N  N   . VAL A 1 396 ? -11.488 -24.140 20.892  1.00 8.09  ?  397  VAL A N   1 
ATOM   3056 C  CA  . VAL A 1 396 ? -12.751 -24.455 21.544  1.00 8.56  ?  397  VAL A CA  1 
ATOM   3057 C  C   . VAL A 1 396 ? -12.545 -25.486 22.647  1.00 10.83 ?  397  VAL A C   1 
ATOM   3058 O  O   . VAL A 1 396 ? -13.113 -25.354 23.735  1.00 10.84 ?  397  VAL A O   1 
ATOM   3059 C  CB  . VAL A 1 396 ? -13.789 -24.905 20.502  1.00 9.71  ?  397  VAL A CB  1 
ATOM   3060 C  CG1 . VAL A 1 396 ? -15.036 -25.509 21.175  1.00 10.04 ?  397  VAL A CG1 1 
ATOM   3061 C  CG2 . VAL A 1 396 ? -14.176 -23.713 19.634  1.00 8.89  ?  397  VAL A CG2 1 
ATOM   3062 N  N   . ALA A 1 397 ? -11.728 -26.518 22.401  1.00 10.42 ?  398  ALA A N   1 
ATOM   3063 C  CA  . ALA A 1 397 ? -11.455 -27.494 23.458  1.00 11.64 ?  398  ALA A CA  1 
ATOM   3064 C  C   . ALA A 1 397 ? -10.846 -26.816 24.680  1.00 11.69 ?  398  ALA A C   1 
ATOM   3065 O  O   . ALA A 1 397 ? -11.239 -27.090 25.820  1.00 12.32 ?  398  ALA A O   1 
ATOM   3066 C  CB  . ALA A 1 397 ? -10.522 -28.587 22.942  1.00 10.11 ?  398  ALA A CB  1 
ATOM   3067 N  N   . GLN A 1 398 ? -9.884  -25.921 24.456  1.00 10.79 ?  399  GLN A N   1 
ATOM   3068 C  CA  . GLN A 1 398 ? -9.244  -25.202 25.552  1.00 11.06 ?  399  GLN A CA  1 
ATOM   3069 C  C   . GLN A 1 398 ? -10.261 -24.369 26.321  1.00 12.85 ?  399  GLN A C   1 
ATOM   3070 O  O   . GLN A 1 398 ? -10.278 -24.373 27.558  1.00 14.15 ?  399  GLN A O   1 
ATOM   3071 C  CB  . GLN A 1 398 ? -8.143  -24.295 24.999  1.00 12.20 ?  399  GLN A CB  1 
ATOM   3072 C  CG  . GLN A 1 398 ? -6.944  -25.025 24.431  1.00 11.65 ?  399  GLN A CG  1 
ATOM   3073 C  CD  . GLN A 1 398 ? -5.988  -24.084 23.724  1.00 13.40 ?  399  GLN A CD  1 
ATOM   3074 O  OE1 . GLN A 1 398 ? -6.335  -22.938 23.428  1.00 13.64 ?  399  GLN A OE1 1 
ATOM   3075 N  NE2 . GLN A 1 398 ? -4.777  -24.559 23.447  1.00 15.12 ?  399  GLN A NE2 1 
ATOM   3076 N  N   . ALA A 1 399 ? -11.108 -23.628 25.601  1.00 10.46 ?  400  ALA A N   1 
ATOM   3077 C  CA  . ALA A 1 399 ? -12.097 -22.786 26.266  1.00 11.04 ?  400  ALA A CA  1 
ATOM   3078 C  C   . ALA A 1 399 ? -13.093 -23.630 27.049  1.00 12.74 ?  400  ALA A C   1 
ATOM   3079 O  O   . ALA A 1 399 ? -13.454 -23.279 28.175  1.00 11.85 ?  400  ALA A O   1 
ATOM   3080 C  CB  . ALA A 1 399 ? -12.827 -21.923 25.240  1.00 10.93 ?  400  ALA A CB  1 
ATOM   3081 N  N   . LEU A 1 400 ? -13.547 -24.747 26.474  1.00 11.14 ?  401  LEU A N   1 
ATOM   3082 C  CA  . LEU A 1 400 ? -14.493 -25.598 27.194  1.00 13.02 ?  401  LEU A CA  1 
ATOM   3083 C  C   . LEU A 1 400 ? -13.863 -26.163 28.463  1.00 13.53 ?  401  LEU A C   1 
ATOM   3084 O  O   . LEU A 1 400 ? -14.522 -26.259 29.507  1.00 12.21 ?  401  LEU A O   1 
ATOM   3085 C  CB  . LEU A 1 400 ? -14.993 -26.715 26.283  1.00 13.73 ?  401  LEU A CB  1 
ATOM   3086 C  CG  . LEU A 1 400 ? -15.941 -26.227 25.181  1.00 13.96 ?  401  LEU A CG  1 
ATOM   3087 C  CD1 . LEU A 1 400 ? -16.380 -27.380 24.304  1.00 16.29 ?  401  LEU A CD1 1 
ATOM   3088 C  CD2 . LEU A 1 400 ? -17.130 -25.488 25.774  1.00 15.13 ?  401  LEU A CD2 1 
ATOM   3089 N  N   . GLU A 1 401 ? -12.578 -26.511 28.413  1.00 13.30 ?  402  GLU A N   1 
ATOM   3090 C  CA  . GLU A 1 401 ? -11.926 -27.012 29.619  1.00 18.40 ?  402  GLU A CA  1 
ATOM   3091 C  C   . GLU A 1 401 ? -11.804 -25.911 30.664  1.00 17.12 ?  402  GLU A C   1 
ATOM   3092 O  O   . GLU A 1 401 ? -11.966 -26.167 31.864  1.00 19.73 ?  402  GLU A O   1 
ATOM   3093 C  CB  . GLU A 1 401 ? -10.565 -27.623 29.277  1.00 16.21 ?  402  GLU A CB  1 
ATOM   3094 N  N   . GLN A 1 402 ? -11.569 -24.672 30.225  1.00 12.91 ?  403  GLN A N   1 
ATOM   3095 C  CA  . GLN A 1 402 ? -11.434 -23.549 31.147  1.00 17.66 ?  403  GLN A CA  1 
ATOM   3096 C  C   . GLN A 1 402 ? -12.755 -23.220 31.839  1.00 17.10 ?  403  GLN A C   1 
ATOM   3097 O  O   . GLN A 1 402 ? -12.788 -22.970 33.053  1.00 19.70 ?  403  GLN A O   1 
ATOM   3098 C  CB  . GLN A 1 402 ? -10.930 -22.325 30.393  1.00 20.45 ?  403  GLN A CB  1 
ATOM   3099 C  CG  . GLN A 1 402 ? -10.756 -21.111 31.270  1.00 27.86 ?  403  GLN A CG  1 
ATOM   3100 C  CD  . GLN A 1 402 ? -10.400 -19.884 30.471  1.00 29.90 ?  403  GLN A CD  1 
ATOM   3101 O  OE1 . GLN A 1 402 ? -10.739 -18.767 30.857  1.00 36.29 ?  403  GLN A OE1 1 
ATOM   3102 N  NE2 . GLN A 1 402 ? -9.757  -20.088 29.321  1.00 28.95 ?  403  GLN A NE2 1 
ATOM   3103 N  N   . TYR A 1 403 ? -13.853 -23.179 31.085  1.00 11.93 ?  404  TYR A N   1 
ATOM   3104 C  CA  . TYR A 1 403 ? -15.139 -22.774 31.657  1.00 12.65 ?  404  TYR A CA  1 
ATOM   3105 C  C   . TYR A 1 403 ? -15.880 -23.902 32.361  1.00 12.26 ?  404  TYR A C   1 
ATOM   3106 O  O   . TYR A 1 403 ? -16.711 -23.622 33.232  1.00 13.53 ?  404  TYR A O   1 
ATOM   3107 C  CB  . TYR A 1 403 ? -16.022 -22.107 30.590  1.00 11.32 ?  404  TYR A CB  1 
ATOM   3108 C  CG  . TYR A 1 403 ? -15.428 -20.803 30.122  1.00 12.11 ?  404  TYR A CG  1 
ATOM   3109 C  CD1 . TYR A 1 403 ? -15.309 -19.726 30.991  1.00 12.52 ?  404  TYR A CD1 1 
ATOM   3110 C  CD2 . TYR A 1 403 ? -14.895 -20.681 28.846  1.00 13.72 ?  404  TYR A CD2 1 
ATOM   3111 C  CE1 . TYR A 1 403 ? -14.729 -18.539 30.582  1.00 12.15 ?  404  TYR A CE1 1 
ATOM   3112 C  CE2 . TYR A 1 403 ? -14.300 -19.510 28.436  1.00 11.61 ?  404  TYR A CE2 1 
ATOM   3113 C  CZ  . TYR A 1 403 ? -14.222 -18.447 29.311  1.00 11.26 ?  404  TYR A CZ  1 
ATOM   3114 O  OH  . TYR A 1 403 ? -13.626 -17.272 28.919  1.00 11.28 ?  404  TYR A OH  1 
ATOM   3115 N  N   . GLY A 1 404 ? -15.616 -25.153 32.005  1.00 10.94 ?  405  GLY A N   1 
ATOM   3116 C  CA  . GLY A 1 404 ? -16.253 -26.269 32.666  1.00 11.85 ?  405  GLY A CA  1 
ATOM   3117 C  C   . GLY A 1 404 ? -17.413 -26.853 31.882  1.00 12.23 ?  405  GLY A C   1 
ATOM   3118 O  O   . GLY A 1 404 ? -17.806 -26.355 30.817  1.00 11.15 ?  405  GLY A O   1 
ATOM   3119 N  N   . PRO A 1 405 ? -18.003 -27.927 32.418  1.00 9.86  ?  406  PRO A N   1 
ATOM   3120 C  CA  . PRO A 1 405 ? -18.967 -28.720 31.634  1.00 10.11 ?  406  PRO A CA  1 
ATOM   3121 C  C   . PRO A 1 405 ? -20.320 -28.074 31.381  1.00 9.83  ?  406  PRO A C   1 
ATOM   3122 O  O   . PRO A 1 405 ? -21.057 -28.587 30.536  1.00 11.78 ?  406  PRO A O   1 
ATOM   3123 C  CB  . PRO A 1 405 ? -19.092 -30.022 32.439  1.00 11.21 ?  406  PRO A CB  1 
ATOM   3124 C  CG  . PRO A 1 405 ? -18.806 -29.613 33.814  1.00 12.34 ?  406  PRO A CG  1 
ATOM   3125 C  CD  . PRO A 1 405 ? -17.682 -28.575 33.701  1.00 11.35 ?  406  PRO A CD  1 
ATOM   3126 N  N   . GLU A 1 406 ? -20.663 -26.958 32.028  1.00 9.74  ?  407  GLU A N   1 
ATOM   3127 C  CA  . GLU A 1 406 ? -21.895 -26.258 31.683  1.00 10.14 ?  407  GLU A CA  1 
ATOM   3128 C  C   . GLU A 1 406 ? -21.731 -25.294 30.510  1.00 12.56 ?  407  GLU A C   1 
ATOM   3129 O  O   . GLU A 1 406 ? -22.740 -24.803 29.988  1.00 13.92 ?  407  GLU A O   1 
ATOM   3130 C  CB  . GLU A 1 406 ? -22.434 -25.498 32.896  1.00 10.42 ?  407  GLU A CB  1 
ATOM   3131 C  CG  . GLU A 1 406 ? -22.968 -26.403 33.995  1.00 10.31 ?  407  GLU A CG  1 
ATOM   3132 C  CD  . GLU A 1 406 ? -23.557 -25.605 35.138  1.00 10.14 ?  407  GLU A CD  1 
ATOM   3133 O  OE1 . GLU A 1 406 ? -22.946 -25.581 36.232  1.00 10.24 ?  407  GLU A OE1 1 
ATOM   3134 O  OE2 . GLU A 1 406 ? -24.622 -24.991 34.932  1.00 12.40 -1 407  GLU A OE2 1 
ATOM   3135 N  N   . ALA A 1 407 ? -20.505 -25.015 30.077  1.00 10.86 ?  408  ALA A N   1 
ATOM   3136 C  CA  . ALA A 1 407 ? -20.307 -24.010 29.038  1.00 10.51 ?  408  ALA A CA  1 
ATOM   3137 C  C   . ALA A 1 407 ? -20.901 -24.459 27.703  1.00 11.40 ?  408  ALA A C   1 
ATOM   3138 O  O   . ALA A 1 407 ? -20.878 -25.643 27.344  1.00 11.52 ?  408  ALA A O   1 
ATOM   3139 C  CB  . ALA A 1 407 ? -18.820 -23.722 28.850  1.00 11.58 ?  408  ALA A CB  1 
ATOM   3140 N  N   . ARG A 1 408 ? -21.414 -23.486 26.953  1.00 10.39 ?  409  ARG A N   1 
ATOM   3141 C  CA  . ARG A 1 408 ? -21.967 -23.718 25.629  1.00 11.45 ?  409  ARG A CA  1 
ATOM   3142 C  C   . ARG A 1 408 ? -21.171 -22.927 24.597  1.00 9.87  ?  409  ARG A C   1 
ATOM   3143 O  O   . ARG A 1 408 ? -20.509 -21.935 24.926  1.00 11.21 ?  409  ARG A O   1 
ATOM   3144 C  CB  . ARG A 1 408 ? -23.424 -23.248 25.563  1.00 14.46 ?  409  ARG A CB  1 
ATOM   3145 C  CG  . ARG A 1 408 ? -24.288 -23.726 26.724  1.00 20.50 ?  409  ARG A CG  1 
ATOM   3146 C  CD  . ARG A 1 408 ? -24.728 -25.147 26.546  1.00 25.03 ?  409  ARG A CD  1 
ATOM   3147 N  NE  . ARG A 1 408 ? -25.543 -25.331 25.349  1.00 28.25 ?  409  ARG A NE  1 
ATOM   3148 C  CZ  . ARG A 1 408 ? -25.594 -26.465 24.656  1.00 30.65 ?  409  ARG A CZ  1 
ATOM   3149 N  NH1 . ARG A 1 408 ? -24.889 -27.520 25.051  1.00 24.07 ?  409  ARG A NH1 1 
ATOM   3150 N  NH2 . ARG A 1 408 ? -26.361 -26.551 23.577  1.00 29.92 ?  409  ARG A NH2 1 
ATOM   3151 N  N   . VAL A 1 409 ? -21.283 -23.355 23.335  1.00 10.57 ?  410  VAL A N   1 
ATOM   3152 C  CA  . VAL A 1 409 ? -20.587 -22.744 22.200  1.00 10.60 ?  410  VAL A CA  1 
ATOM   3153 C  C   . VAL A 1 409 ? -21.617 -22.264 21.186  1.00 11.02 ?  410  VAL A C   1 
ATOM   3154 O  O   . VAL A 1 409 ? -22.494 -23.030 20.775  1.00 10.69 ?  410  VAL A O   1 
ATOM   3155 C  CB  . VAL A 1 409 ? -19.640 -23.742 21.506  1.00 10.16 ?  410  VAL A CB  1 
ATOM   3156 C  CG1 . VAL A 1 409 ? -18.849 -23.050 20.394  1.00 11.66 ?  410  VAL A CG1 1 
ATOM   3157 C  CG2 . VAL A 1 409 ? -18.716 -24.420 22.497  1.00 12.71 ?  410  VAL A CG2 1 
ATOM   3158 N  N   . ALA A 1 410 ? -21.488 -21.013 20.747  1.00 10.90 ?  411  ALA A N   1 
ATOM   3159 C  CA  . ALA A 1 410 ? -22.222 -20.522 19.590  1.00 10.32 ?  411  ALA A CA  1 
ATOM   3160 C  C   . ALA A 1 410 ? -21.237 -20.324 18.449  1.00 8.51  ?  411  ALA A C   1 
ATOM   3161 O  O   . ALA A 1 410 ? -20.045 -20.110 18.684  1.00 10.88 ?  411  ALA A O   1 
ATOM   3162 C  CB  . ALA A 1 410 ? -22.916 -19.195 19.908  1.00 12.27 ?  411  ALA A CB  1 
ATOM   3163 N  N   . VAL A 1 411 ? -21.731 -20.405 17.212  1.00 8.07  ?  412  VAL A N   1 
ATOM   3164 C  CA  . VAL A 1 411 ? -20.884 -20.265 16.032  1.00 8.89  ?  412  VAL A CA  1 
ATOM   3165 C  C   . VAL A 1 411 ? -21.561 -19.367 15.006  1.00 8.55  ?  412  VAL A C   1 
ATOM   3166 O  O   . VAL A 1 411 ? -22.759 -19.506 14.740  1.00 8.94  ?  412  VAL A O   1 
ATOM   3167 C  CB  . VAL A 1 411 ? -20.444 -21.630 15.454  1.00 11.27 ?  412  VAL A CB  1 
ATOM   3168 C  CG1 . VAL A 1 411 ? -21.622 -22.441 14.977  1.00 15.15 ?  412  VAL A CG1 1 
ATOM   3169 C  CG2 . VAL A 1 411 ? -19.487 -21.422 14.297  1.00 12.66 ?  412  VAL A CG2 1 
ATOM   3170 N  N   . ILE A 1 412 ? -20.788 -18.439 14.442  1.00 7.46  ?  413  ILE A N   1 
ATOM   3171 C  CA  . ILE A 1 412 ? -21.256 -17.436 13.482  1.00 8.09  ?  413  ILE A CA  1 
ATOM   3172 C  C   . ILE A 1 412 ? -20.396 -17.530 12.233  1.00 8.17  ?  413  ILE A C   1 
ATOM   3173 O  O   . ILE A 1 412 ? -19.405 -16.799 12.107  1.00 8.09  ?  413  ILE A O   1 
ATOM   3174 C  CB  . ILE A 1 412 ? -21.214 -16.010 14.059  1.00 7.25  ?  413  ILE A CB  1 
ATOM   3175 C  CG1 . ILE A 1 412 ? -21.711 -15.965 15.509  1.00 8.65  ?  413  ILE A CG1 1 
ATOM   3176 C  CG2 . ILE A 1 412 ? -22.023 -15.065 13.189  1.00 8.52  ?  413  ILE A CG2 1 
ATOM   3177 C  CD1 . ILE A 1 412 ? -21.386 -14.640 16.208  1.00 11.33 ?  413  ILE A CD1 1 
ATOM   3178 N  N   . PRO A 1 413 ? -20.740 -18.392 11.280  1.00 7.47  ?  414  PRO A N   1 
ATOM   3179 C  CA  . PRO A 1 413 ? -19.844 -18.579 10.125  1.00 8.67  ?  414  PRO A CA  1 
ATOM   3180 C  C   . PRO A 1 413 ? -19.527 -17.308 9.343   1.00 9.78  ?  414  PRO A C   1 
ATOM   3181 O  O   . PRO A 1 413 ? -18.374 -17.145 8.925   1.00 9.19  ?  414  PRO A O   1 
ATOM   3182 C  CB  . PRO A 1 413 ? -20.574 -19.640 9.287   1.00 9.97  ?  414  PRO A CB  1 
ATOM   3183 C  CG  . PRO A 1 413 ? -21.357 -20.418 10.326  1.00 10.05 ?  414  PRO A CG  1 
ATOM   3184 C  CD  . PRO A 1 413 ? -21.840 -19.374 11.295  1.00 8.91  ?  414  PRO A CD  1 
ATOM   3185 N  N   . LYS A 1 414 ? -20.494 -16.401 9.155   1.00 8.06  ?  415  LYS A N   1 
ATOM   3186 C  CA  A LYS A 1 414 ? -20.289 -15.183 8.375   0.70 8.87  ?  415  LYS A CA  1 
ATOM   3187 C  CA  B LYS A 1 414 ? -20.314 -15.177 8.381   0.30 8.91  ?  415  LYS A CA  1 
ATOM   3188 C  C   . LYS A 1 414 ? -19.877 -13.995 9.244   1.00 8.70  ?  415  LYS A C   1 
ATOM   3189 O  O   . LYS A 1 414 ? -19.817 -12.860 8.752   1.00 8.96  ?  415  LYS A O   1 
ATOM   3190 C  CB  A LYS A 1 414 ? -21.547 -14.864 7.557   0.70 9.86  ?  415  LYS A CB  1 
ATOM   3191 C  CB  B LYS A 1 414 ? -21.607 -14.836 7.631   0.30 9.87  ?  415  LYS A CB  1 
ATOM   3192 C  CG  A LYS A 1 414 ? -21.600 -15.530 6.175   0.70 12.31 ?  415  LYS A CG  1 
ATOM   3193 C  CG  B LYS A 1 414 ? -21.719 -15.455 6.241   0.30 12.42 ?  415  LYS A CG  1 
ATOM   3194 C  CD  A LYS A 1 414 ? -21.391 -17.037 6.221   0.70 10.78 ?  415  LYS A CD  1 
ATOM   3195 C  CD  B LYS A 1 414 ? -21.691 -16.975 6.291   0.30 11.22 ?  415  LYS A CD  1 
ATOM   3196 C  CE  A LYS A 1 414 ? -21.650 -17.672 4.846   0.70 10.67 ?  415  LYS A CE  1 
ATOM   3197 C  CE  B LYS A 1 414 ? -21.653 -17.578 4.893   0.30 10.76 ?  415  LYS A CE  1 
ATOM   3198 N  NZ  A LYS A 1 414 ? -20.615 -17.264 3.843   0.70 10.05 ?  415  LYS A NZ  1 
ATOM   3199 N  NZ  B LYS A 1 414 ? -21.421 -19.044 4.945   0.30 15.63 ?  415  LYS A NZ  1 
ATOM   3200 N  N   . GLY A 1 415 ? -19.598 -14.229 10.520  1.00 8.53  ?  416  GLY A N   1 
ATOM   3201 C  CA  . GLY A 1 415 ? -19.014 -13.227 11.376  1.00 7.68  ?  416  GLY A CA  1 
ATOM   3202 C  C   . GLY A 1 415 ? -19.769 -11.916 11.407  1.00 8.68  ?  416  GLY A C   1 
ATOM   3203 O  O   . GLY A 1 415 ? -20.967 -11.861 11.703  1.00 8.63  ?  416  GLY A O   1 
ATOM   3204 N  N   . PRO A 1 416 ? -19.072 -10.823 11.081  1.00 7.26  ?  417  PRO A N   1 
ATOM   3205 C  CA  . PRO A 1 416 ? -19.668 -9.492  11.232  1.00 7.99  ?  417  PRO A CA  1 
ATOM   3206 C  C   . PRO A 1 416 ? -20.744 -9.162  10.211  1.00 8.11  ?  417  PRO A C   1 
ATOM   3207 O  O   . PRO A 1 416 ? -21.334 -8.079  10.305  1.00 9.45  ?  417  PRO A O   1 
ATOM   3208 C  CB  . PRO A 1 416 ? -18.446 -8.563  11.127  1.00 8.47  ?  417  PRO A CB  1 
ATOM   3209 C  CG  . PRO A 1 416 ? -17.571 -9.282  10.130  1.00 7.90  ?  417  PRO A CG  1 
ATOM   3210 C  CD  . PRO A 1 416 ? -17.688 -10.744 10.566  1.00 7.38  ?  417  PRO A CD  1 
ATOM   3211 N  N   . TYR A 1 417 ? -21.044 -10.053 9.263   1.00 7.36  ?  418  TYR A N   1 
ATOM   3212 C  CA  . TYR A 1 417 ? -22.191 -9.864  8.386   1.00 8.32  ?  418  TYR A CA  1 
ATOM   3213 C  C   . TYR A 1 417 ? -23.471 -10.432 9.000   1.00 10.08 ?  418  TYR A C   1 
ATOM   3214 O  O   . TYR A 1 417 ? -24.531 -10.396 8.362   1.00 11.19 ?  418  TYR A O   1 
ATOM   3215 C  CB  . TYR A 1 417 ? -21.914 -10.502 7.021   1.00 8.40  ?  418  TYR A CB  1 
ATOM   3216 C  CG  . TYR A 1 417 ? -20.822 -9.813  6.202   1.00 7.26  ?  418  TYR A CG  1 
ATOM   3217 C  CD1 . TYR A 1 417 ? -20.258 -8.589  6.579   1.00 7.63  ?  418  TYR A CD1 1 
ATOM   3218 C  CD2 . TYR A 1 417 ? -20.332 -10.421 5.054   1.00 9.69  ?  418  TYR A CD2 1 
ATOM   3219 C  CE1 . TYR A 1 417 ? -19.240 -7.996  5.814   1.00 9.41  ?  418  TYR A CE1 1 
ATOM   3220 C  CE2 . TYR A 1 417 ? -19.328 -9.839  4.288   1.00 8.11  ?  418  TYR A CE2 1 
ATOM   3221 C  CZ  . TYR A 1 417 ? -18.783 -8.639  4.666   1.00 7.88  ?  418  TYR A CZ  1 
ATOM   3222 O  OH  . TYR A 1 417 ? -17.769 -8.108  3.888   1.00 9.02  ?  418  TYR A OH  1 
ATOM   3223 N  N   . VAL A 1 418 ? -23.399 -10.926 10.239  1.00 8.59  ?  419  VAL A N   1 
ATOM   3224 C  CA  . VAL A 1 418 ? -24.562 -11.355 11.005  1.00 8.98  ?  419  VAL A CA  1 
ATOM   3225 C  C   . VAL A 1 418 ? -24.674 -10.436 12.212  1.00 9.15  ?  419  VAL A C   1 
ATOM   3226 O  O   . VAL A 1 418 ? -23.664 -9.953  12.739  1.00 11.03 ?  419  VAL A O   1 
ATOM   3227 C  CB  . VAL A 1 418 ? -24.392 -12.824 11.457  1.00 7.37  ?  419  VAL A CB  1 
ATOM   3228 C  CG1 . VAL A 1 418 ? -25.556 -13.276 12.333  1.00 10.02 ?  419  VAL A CG1 1 
ATOM   3229 C  CG2 . VAL A 1 418 ? -24.220 -13.726 10.259  1.00 9.57  ?  419  VAL A CG2 1 
ATOM   3230 N  N   . LEU A 1 419 ? -25.908 -10.204 12.660  1.00 9.10  ?  420  LEU A N   1 
ATOM   3231 C  CA  . LEU A 1 419 ? -26.176 -9.434  13.871  1.00 10.59 ?  420  LEU A CA  1 
ATOM   3232 C  C   . LEU A 1 419 ? -26.708 -10.385 14.939  1.00 11.97 ?  420  LEU A C   1 
ATOM   3233 O  O   . LEU A 1 419 ? -27.924 -10.630 15.012  1.00 13.15 ?  420  LEU A O   1 
ATOM   3234 C  CB  . LEU A 1 419 ? -27.199 -8.343  13.550  1.00 15.18 ?  420  LEU A CB  1 
ATOM   3235 C  CG  . LEU A 1 419 ? -27.282 -7.146  14.481  1.00 24.08 ?  420  LEU A CG  1 
ATOM   3236 C  CD1 . LEU A 1 419 ? -25.943 -6.417  14.425  1.00 24.42 ?  420  LEU A CD1 1 
ATOM   3237 C  CD2 . LEU A 1 419 ? -28.395 -6.221  14.013  1.00 18.96 ?  420  LEU A CD2 1 
ATOM   3238 N  N   . PRO A 1 420 ? -25.841 -10.975 15.763  1.00 10.89 ?  421  PRO A N   1 
ATOM   3239 C  CA  . PRO A 1 420 ? -26.321 -11.875 16.817  1.00 12.54 ?  421  PRO A CA  1 
ATOM   3240 C  C   . PRO A 1 420 ? -26.966 -11.096 17.948  1.00 15.82 ?  421  PRO A C   1 
ATOM   3241 O  O   . PRO A 1 420 ? -26.510 -10.015 18.325  1.00 18.87 ?  421  PRO A O   1 
ATOM   3242 C  CB  . PRO A 1 420 ? -25.044 -12.577 17.286  1.00 16.30 ?  421  PRO A CB  1 
ATOM   3243 C  CG  . PRO A 1 420 ? -23.961 -11.627 17.001  1.00 15.76 ?  421  PRO A CG  1 
ATOM   3244 C  CD  . PRO A 1 420 ? -24.371 -10.868 15.750  1.00 11.76 ?  421  PRO A CD  1 
ATOM   3245 N  N   . VAL A 1 421 ? -28.058 -11.645 18.473  1.00 17.57 ?  422  VAL A N   1 
ATOM   3246 C  CA  . VAL A 1 421 ? -28.847 -10.965 19.491  1.00 20.48 ?  422  VAL A CA  1 
ATOM   3247 C  C   . VAL A 1 421 ? -29.332 -11.987 20.508  1.00 21.53 ?  422  VAL A C   1 
ATOM   3248 O  O   . VAL A 1 421 ? -29.449 -13.180 20.217  1.00 21.61 ?  422  VAL A O   1 
ATOM   3249 C  CB  . VAL A 1 421 ? -30.039 -10.187 18.891  1.00 21.79 ?  422  VAL A CB  1 
ATOM   3250 C  CG1 . VAL A 1 421 ? -29.542 -8.985  18.091  1.00 21.57 ?  422  VAL A CG1 1 
ATOM   3251 C  CG2 . VAL A 1 421 ? -30.880 -11.097 18.032  1.00 25.00 ?  422  VAL A CG2 1 
ATOM   3252 N  N   . VAL A 1 422 ? -29.595 -11.506 21.716  1.00 22.11 ?  423  VAL A N   1 
ATOM   3253 C  CA  . VAL A 1 422 ? -30.195 -12.309 22.771  1.00 23.02 ?  423  VAL A CA  1 
ATOM   3254 C  C   . VAL A 1 422 ? -31.659 -11.902 22.859  1.00 23.80 ?  423  VAL A C   1 
ATOM   3255 O  O   . VAL A 1 422 ? -31.969 -10.720 23.051  1.00 28.25 ?  423  VAL A O   1 
ATOM   3256 C  CB  . VAL A 1 422 ? -29.493 -12.069 24.116  1.00 19.97 ?  423  VAL A CB  1 
ATOM   3257 C  CG1 . VAL A 1 422 ? -30.284 -12.731 25.246  1.00 20.96 ?  423  VAL A CG1 1 
ATOM   3258 C  CG2 . VAL A 1 422 ? -28.060 -12.567 24.076  1.00 19.52 ?  423  VAL A CG2 1 
ATOM   3259 N  N   . ASP A 1 423 ? -32.561 -12.866 22.700  1.00 28.97 ?  424  ASP A N   1 
ATOM   3260 C  CA  . ASP A 1 423 ? -33.980 -12.626 22.937  1.00 34.57 ?  424  ASP A CA  1 
ATOM   3261 C  C   . ASP A 1 423 ? -34.411 -13.454 24.140  1.00 30.84 ?  424  ASP A C   1 
ATOM   3262 O  O   . ASP A 1 423 ? -34.592 -14.675 24.018  1.00 29.98 ?  424  ASP A O   1 
ATOM   3263 C  CB  . ASP A 1 423 ? -34.810 -13.000 21.706  1.00 32.33 ?  424  ASP A CB  1 
ATOM   3264 C  CG  . ASP A 1 423 ? -36.249 -12.524 21.808  1.00 43.34 ?  424  ASP A CG  1 
ATOM   3265 O  OD1 . ASP A 1 423 ? -36.638 -12.004 22.880  1.00 39.44 ?  424  ASP A OD1 1 
ATOM   3266 O  OD2 . ASP A 1 423 ? -36.993 -12.671 20.815  1.00 49.04 -1 424  ASP A OD2 1 
ATOM   3267 N  N   . PRO A 1 424 ? -34.591 -12.845 25.319  1.00 33.91 ?  425  PRO A N   1 
ATOM   3268 C  CA  . PRO A 1 424 ? -34.940 -13.630 26.515  1.00 36.01 ?  425  PRO A CA  1 
ATOM   3269 C  C   . PRO A 1 424 ? -36.321 -14.253 26.459  1.00 40.16 ?  425  PRO A C   1 
ATOM   3270 O  O   . PRO A 1 424 ? -36.617 -15.128 27.285  1.00 38.18 ?  425  PRO A O   1 
ATOM   3271 C  CB  . PRO A 1 424 ? -34.844 -12.595 27.652  1.00 37.63 ?  425  PRO A CB  1 
ATOM   3272 C  CG  . PRO A 1 424 ? -34.054 -11.439 27.040  1.00 40.37 ?  425  PRO A CG  1 
ATOM   3273 C  CD  . PRO A 1 424 ? -34.557 -11.412 25.634  1.00 34.03 ?  425  PRO A CD  1 
ATOM   3274 N  N   . THR A 1 425 ? -37.166 -13.836 25.522  1.00 37.83 ?  426  THR A N   1 
ATOM   3275 C  CA  . THR A 1 425 ? -38.503 -14.388 25.385  1.00 39.18 ?  426  THR A CA  1 
ATOM   3276 C  C   . THR A 1 425 ? -38.471 -15.606 24.470  1.00 39.73 ?  426  THR A C   1 
ATOM   3277 O  O   . THR A 1 425 ? -39.454 -16.339 24.366  1.00 49.72 ?  426  THR A O   1 
ATOM   3278 C  CB  . THR A 1 425 ? -39.479 -13.347 24.806  1.00 41.32 ?  426  THR A CB  1 
ATOM   3279 O  OG1 . THR A 1 425 ? -39.180 -13.129 23.422  1.00 41.40 ?  426  THR A OG1 1 
ATOM   3280 C  CG2 . THR A 1 425 ? -39.357 -12.026 25.559  1.00 41.60 ?  426  THR A CG2 1 
HETATM 3281 C  CAA . UCU B 2 .   ? -13.792 0.394   8.307   1.00 6.74  ?  501  UCU A CAA 1 
HETATM 3282 C  CAB . UCU B 2 .   ? -12.943 1.118   9.302   1.00 14.50 ?  501  UCU A CAB 1 
HETATM 3283 C  CAC . UCU B 2 .   ? -12.901 0.223   10.533  1.00 13.62 ?  501  UCU A CAC 1 
HETATM 3284 C  CAD . UCU B 2 .   ? -12.622 1.084   11.758  1.00 21.46 ?  501  UCU A CAD 1 
HETATM 3285 O  OAE . UCU B 2 .   ? -13.291 -0.077  7.236   1.00 9.27  -1 501  UCU A OAE 1 
HETATM 3286 O  OAF . UCU B 2 .   ? -15.023 0.253   8.547   1.00 10.47 ?  501  UCU A OAF 1 
HETATM 3287 O  OAG . UCU B 2 .   ? -11.685 1.286   8.748   1.00 11.11 ?  501  UCU A OAG 1 
HETATM 3288 C  C2  . 4EY C 3 .   ? -15.473 3.334   5.955   1.00 8.02  ?  502  4EY A C2  1 
HETATM 3289 C  C3  . 4EY C 3 .   ? -15.435 3.571   7.339   1.00 7.93  ?  502  4EY A C3  1 
HETATM 3290 C  C1  . 4EY C 3 .   ? -11.857 4.409   7.779   1.00 7.39  ?  502  4EY A C1  1 
HETATM 3291 C  C4  . 4EY C 3 .   ? -14.235 3.940   7.937   1.00 7.86  ?  502  4EY A C4  1 
HETATM 3292 C  C5  . 4EY C 3 .   ? -13.106 3.991   7.139   1.00 7.75  ?  502  4EY A C5  1 
HETATM 3293 C  C6  . 4EY C 3 .   ? -13.193 3.740   5.769   1.00 8.64  ?  502  4EY A C6  1 
HETATM 3294 O  O2  . 4EY C 3 .   ? -10.792 4.438   7.191   1.00 9.35  ?  502  4EY A O2  1 
HETATM 3295 O  O2P . 4EY C 3 .   ? -18.805 1.403   5.713   1.00 6.95  -1 502  4EY A O2P 1 
HETATM 3296 P  P   . 4EY C 3 .   ? -19.006 1.748   4.195   1.00 7.17  ?  502  4EY A P   1 
HETATM 3297 O  O3P . 4EY C 3 .   ? -18.752 0.582   3.315   1.00 7.97  ?  502  4EY A O3P 1 
HETATM 3298 O  O1P . 4EY C 3 .   ? -20.406 2.405   3.904   1.00 8.82  -1 502  4EY A O1P 1 
HETATM 3299 O  O5R . 4EY C 3 .   ? -17.838 2.824   3.968   1.00 7.64  ?  502  4EY A O5R 1 
HETATM 3300 C  C5R . 4EY C 3 .   ? -17.728 3.524   2.721   1.00 7.25  ?  502  4EY A C5R 1 
HETATM 3301 C  C4R . 4EY C 3 .   ? -16.261 3.504   2.270   1.00 6.51  ?  502  4EY A C4R 1 
HETATM 3302 O  O4R . 4EY C 3 .   ? -15.435 4.128   3.304   1.00 7.16  ?  502  4EY A O4R 1 
HETATM 3303 C  C3R . 4EY C 3 .   ? -15.693 2.083   2.080   1.00 5.67  ?  502  4EY A C3R 1 
HETATM 3304 O  O3R . 4EY C 3 .   ? -14.759 2.070   0.994   1.00 7.05  ?  502  4EY A O3R 1 
HETATM 3305 C  C2R . 4EY C 3 .   ? -14.956 1.813   3.404   1.00 6.41  ?  502  4EY A C2R 1 
HETATM 3306 O  O2R . 4EY C 3 .   ? -13.881 0.879   3.248   1.00 7.51  ?  502  4EY A O2R 1 
HETATM 3307 C  C1R . 4EY C 3 .   ? -14.426 3.197   3.777   1.00 7.66  ?  502  4EY A C1R 1 
HETATM 3308 N  N1  . 4EY C 3 .   ? -14.356 3.408   5.223   1.00 7.04  ?  502  4EY A N1  1 
HETATM 3309 C  C7  . 4EY C 3 .   ? -16.599 3.544   8.228   1.00 6.77  ?  502  4EY A C7  1 
HETATM 3310 S  S7  . 4EY C 3 .   ? -16.414 4.207   9.703   1.00 8.33  ?  502  4EY A S7  1 
HETATM 3311 S  S2  . 4EY C 3 .   ? -12.060 4.975   9.416   1.00 10.60 ?  502  4EY A S2  1 
HETATM 3312 NI NI  . NI  D 4 .   ? -14.240 4.681   9.683   0.79 7.48  ?  503  NI  A NI  1 
HETATM 3313 P  P   . PO4 E 5 .   ? -19.394 9.059   -24.915 1.00 13.65 ?  504  PO4 A P   1 
HETATM 3314 O  O1  . PO4 E 5 .   ? -18.180 9.651   -24.262 1.00 14.28 ?  504  PO4 A O1  1 
HETATM 3315 O  O2  . PO4 E 5 .   ? -19.767 9.861   -26.129 1.00 23.10 ?  504  PO4 A O2  1 
HETATM 3316 O  O3  . PO4 E 5 .   ? -19.077 7.655   -25.369 1.00 19.05 -1 504  PO4 A O3  1 
HETATM 3317 O  O4  . PO4 E 5 .   ? -20.542 9.050   -23.945 1.00 24.03 ?  504  PO4 A O4  1 
HETATM 3318 P  P   . PO4 F 5 .   ? -30.832 15.381  13.004  1.00 19.64 ?  505  PO4 A P   1 
HETATM 3319 O  O1  . PO4 F 5 .   ? -29.370 15.051  12.823  1.00 20.30 ?  505  PO4 A O1  1 
HETATM 3320 O  O2  . PO4 F 5 .   ? -31.558 15.279  11.681  1.00 25.76 ?  505  PO4 A O2  1 
HETATM 3321 O  O3  . PO4 F 5 .   ? -31.451 14.411  13.984  1.00 29.73 -1 505  PO4 A O3  1 
HETATM 3322 O  O4  . PO4 F 5 .   ? -30.976 16.788  13.531  1.00 25.50 ?  505  PO4 A O4  1 
HETATM 3323 O  O   . HOH G 6 .   ? -9.508  13.568  -12.619 1.00 33.62 ?  601  HOH A O   1 
HETATM 3324 O  O   . HOH G 6 .   ? -20.242 22.177  -9.918  1.00 31.71 ?  602  HOH A O   1 
HETATM 3325 O  O   . HOH G 6 .   ? 5.006   -12.441 21.261  1.00 29.02 ?  603  HOH A O   1 
HETATM 3326 O  O   . HOH G 6 .   ? -25.791 -8.041  17.209  1.00 21.63 ?  604  HOH A O   1 
HETATM 3327 O  O   . HOH G 6 .   ? -30.397 -19.030 7.734   1.00 27.88 ?  605  HOH A O   1 
HETATM 3328 O  O   . HOH G 6 .   ? -4.519  -24.025 11.634  1.00 17.66 ?  606  HOH A O   1 
HETATM 3329 O  O   . HOH G 6 .   ? -11.159 -29.749 10.849  1.00 15.52 ?  607  HOH A O   1 
HETATM 3330 O  O   . HOH G 6 .   ? -6.655  5.701   35.066  1.00 23.83 ?  608  HOH A O   1 
HETATM 3331 O  O   . HOH G 6 .   ? 0.824   7.653   17.804  1.00 32.84 ?  609  HOH A O   1 
HETATM 3332 O  O   . HOH G 6 .   ? 5.092   -3.927  10.126  1.00 35.69 ?  610  HOH A O   1 
HETATM 3333 O  O   . HOH G 6 .   ? -23.347 -28.699 29.419  1.00 23.90 ?  611  HOH A O   1 
HETATM 3334 O  O   . HOH G 6 .   ? -22.933 -26.762 10.959  1.00 29.88 ?  612  HOH A O   1 
HETATM 3335 O  O   . HOH G 6 .   ? -22.166 -20.955 28.420  1.00 9.77  ?  613  HOH A O   1 
HETATM 3336 O  O   . HOH G 6 .   ? 1.863   -5.090  22.049  1.00 20.14 ?  614  HOH A O   1 
HETATM 3337 O  O   . HOH G 6 .   ? -25.411 -9.664  6.041   1.00 15.14 ?  615  HOH A O   1 
HETATM 3338 O  O   . HOH G 6 .   ? -38.807 9.859   -9.619  1.00 24.11 ?  616  HOH A O   1 
HETATM 3339 O  O   . HOH G 6 .   ? -8.374  3.482   8.264   1.00 13.94 ?  617  HOH A O   1 
HETATM 3340 O  O   . HOH G 6 .   ? -2.316  16.772  -3.534  1.00 21.60 ?  618  HOH A O   1 
HETATM 3341 O  O   . HOH G 6 .   ? -37.462 2.589   -6.322  1.00 24.61 ?  619  HOH A O   1 
HETATM 3342 O  O   . HOH G 6 .   ? -35.782 0.171   9.962   1.00 23.79 ?  620  HOH A O   1 
HETATM 3343 O  O   . HOH G 6 .   ? -30.334 12.683  15.611  1.00 26.65 ?  621  HOH A O   1 
HETATM 3344 O  O   . HOH G 6 .   ? -17.307 7.426   14.535  1.00 14.50 ?  622  HOH A O   1 
HETATM 3345 O  O   . HOH G 6 .   ? -10.106 -32.627 18.713  1.00 32.63 ?  623  HOH A O   1 
HETATM 3346 O  O   . HOH G 6 .   ? -26.887 -2.897  -17.376 1.00 18.21 ?  624  HOH A O   1 
HETATM 3347 O  O   . HOH G 6 .   ? -26.151 16.589  -20.582 1.00 23.27 ?  625  HOH A O   1 
HETATM 3348 O  O   . HOH G 6 .   ? -0.171  -3.319  22.803  1.00 14.95 ?  626  HOH A O   1 
HETATM 3349 O  O   . HOH G 6 .   ? -29.978 12.446  -2.325  1.00 18.41 ?  627  HOH A O   1 
HETATM 3350 O  O   . HOH G 6 .   ? -25.277 -24.151 30.245  1.00 24.56 ?  628  HOH A O   1 
HETATM 3351 O  O   . HOH G 6 .   ? -12.501 -17.825 -3.779  1.00 26.84 ?  629  HOH A O   1 
HETATM 3352 O  O   . HOH G 6 .   ? -28.362 13.098  11.373  1.00 14.13 ?  630  HOH A O   1 
HETATM 3353 O  O   . HOH G 6 .   ? -4.776  12.093  23.695  1.00 32.37 ?  631  HOH A O   1 
HETATM 3354 O  O   . HOH G 6 .   ? -27.376 15.660  19.167  1.00 14.59 ?  632  HOH A O   1 
HETATM 3355 O  O   . HOH G 6 .   ? -14.452 -30.164 18.104  1.00 27.90 ?  633  HOH A O   1 
HETATM 3356 O  O   . HOH G 6 .   ? -0.798  -17.281 13.874  1.00 28.44 ?  634  HOH A O   1 
HETATM 3357 O  O   . HOH G 6 .   ? -21.838 -10.371 -5.250  1.00 21.34 ?  635  HOH A O   1 
HETATM 3358 O  O   . HOH G 6 .   ? -25.272 -19.472 31.189  1.00 26.35 ?  636  HOH A O   1 
HETATM 3359 O  O   . HOH G 6 .   ? -25.202 -8.692  -14.319 1.00 18.97 ?  637  HOH A O   1 
HETATM 3360 O  O   . HOH G 6 .   ? 0.182   -12.381 5.521   1.00 25.81 ?  638  HOH A O   1 
HETATM 3361 O  O   . HOH G 6 .   ? -5.940  -6.998  -2.108  1.00 14.35 ?  639  HOH A O   1 
HETATM 3362 O  O   . HOH G 6 .   ? -17.918 1.864   19.660  1.00 13.31 ?  640  HOH A O   1 
HETATM 3363 O  O   . HOH G 6 .   ? -20.536 -18.444 33.051  1.00 25.96 ?  641  HOH A O   1 
HETATM 3364 O  O   . HOH G 6 .   ? -35.901 -0.852  -4.343  1.00 29.45 ?  642  HOH A O   1 
HETATM 3365 O  O   . HOH G 6 .   ? -7.038  14.110  -9.826  1.00 29.28 ?  643  HOH A O   1 
HETATM 3366 O  O   . HOH G 6 .   ? -3.642  10.034  2.771   1.00 16.37 ?  644  HOH A O   1 
HETATM 3367 O  O   . HOH G 6 .   ? -19.721 -2.974  7.087   1.00 11.59 ?  645  HOH A O   1 
HETATM 3368 O  O   . HOH G 6 .   ? -7.523  -16.623 25.523  1.00 24.83 ?  646  HOH A O   1 
HETATM 3369 O  O   . HOH G 6 .   ? -20.855 -17.808 -2.800  1.00 32.82 ?  647  HOH A O   1 
HETATM 3370 O  O   . HOH G 6 .   ? -37.524 -3.915  8.700   1.00 22.95 ?  648  HOH A O   1 
HETATM 3371 O  O   . HOH G 6 .   ? -18.694 -19.880 5.200   1.00 16.98 ?  649  HOH A O   1 
HETATM 3372 O  O   . HOH G 6 .   ? -13.109 9.613   -16.998 1.00 17.00 ?  650  HOH A O   1 
HETATM 3373 O  O   . HOH G 6 .   ? -3.798  6.424   -6.154  1.00 20.28 ?  651  HOH A O   1 
HETATM 3374 O  O   . HOH G 6 .   ? -2.429  2.964   -5.578  1.00 23.91 ?  652  HOH A O   1 
HETATM 3375 O  O   . HOH G 6 .   ? -24.674 -1.696  22.290  1.00 19.52 ?  653  HOH A O   1 
HETATM 3376 O  O   . HOH G 6 .   ? -22.347 -8.131  14.174  1.00 19.26 ?  654  HOH A O   1 
HETATM 3377 O  O   . HOH G 6 .   ? -27.856 -13.279 -11.020 1.00 24.75 ?  655  HOH A O   1 
HETATM 3378 O  O   . HOH G 6 .   ? -28.716 -11.921 -6.861  1.00 11.26 ?  656  HOH A O   1 
HETATM 3379 O  O   . HOH G 6 .   ? -18.696 -11.885 14.529  1.00 13.43 ?  657  HOH A O   1 
HETATM 3380 O  O   . HOH G 6 .   ? -27.591 -9.344  4.169   1.00 12.08 ?  658  HOH A O   1 
HETATM 3381 O  O   . HOH G 6 .   ? -28.535 8.537   15.362  1.00 16.31 ?  659  HOH A O   1 
HETATM 3382 O  O   . HOH G 6 .   ? 1.279   -6.742  3.810   1.00 30.87 ?  660  HOH A O   1 
HETATM 3383 O  O   . HOH G 6 .   ? -30.622 -15.230 0.697   1.00 15.08 ?  661  HOH A O   1 
HETATM 3384 O  O   . HOH G 6 .   ? -33.158 1.033   12.280  1.00 23.83 ?  662  HOH A O   1 
HETATM 3385 O  O   . HOH G 6 .   ? -34.863 -10.714 -1.358  1.00 12.88 ?  663  HOH A O   1 
HETATM 3386 O  O   . HOH G 6 .   ? -8.977  23.440  0.401   1.00 24.02 ?  664  HOH A O   1 
HETATM 3387 O  O   . HOH G 6 .   ? -20.308 -14.016 33.110  1.00 30.86 ?  665  HOH A O   1 
HETATM 3388 O  O   . HOH G 6 .   ? -13.416 23.119  -3.858  1.00 17.34 ?  666  HOH A O   1 
HETATM 3389 O  O   . HOH G 6 .   ? -16.853 27.929  10.187  1.00 21.82 ?  667  HOH A O   1 
HETATM 3390 O  O   . HOH G 6 .   ? -25.045 6.663   -28.233 1.00 28.72 ?  668  HOH A O   1 
HETATM 3391 O  O   . HOH G 6 .   ? -17.812 -35.283 13.483  1.00 29.91 ?  669  HOH A O   1 
HETATM 3392 O  O   . HOH G 6 .   ? -22.102 -5.005  21.555  1.00 22.52 ?  670  HOH A O   1 
HETATM 3393 O  O   . HOH G 6 .   ? -7.053  3.092   -20.813 1.00 28.52 ?  671  HOH A O   1 
HETATM 3394 O  O   . HOH G 6 .   ? -30.849 -3.041  13.374  1.00 16.88 ?  672  HOH A O   1 
HETATM 3395 O  O   . HOH G 6 .   ? -26.827 -8.881  24.387  1.00 25.79 ?  673  HOH A O   1 
HETATM 3396 O  O   . HOH G 6 .   ? -37.023 -13.331 3.576   1.00 27.37 ?  674  HOH A O   1 
HETATM 3397 O  O   . HOH G 6 .   ? -23.801 -10.501 3.735   1.00 11.99 ?  675  HOH A O   1 
HETATM 3398 O  O   . HOH G 6 .   ? 4.139   -2.850  23.494  1.00 29.97 ?  676  HOH A O   1 
HETATM 3399 O  O   . HOH G 6 .   ? -21.683 -6.075  25.704  1.00 30.79 ?  677  HOH A O   1 
HETATM 3400 O  O   . HOH G 6 .   ? -0.889  7.070   21.274  1.00 26.42 ?  678  HOH A O   1 
HETATM 3401 O  O   . HOH G 6 .   ? -38.586 1.066   -13.388 1.00 23.00 ?  679  HOH A O   1 
HETATM 3402 O  O   . HOH G 6 .   ? -8.598  4.482   -16.253 1.00 21.36 ?  680  HOH A O   1 
HETATM 3403 O  O   . HOH G 6 .   ? -20.657 6.381   -19.633 1.00 12.75 ?  681  HOH A O   1 
HETATM 3404 O  O   . HOH G 6 .   ? -7.156  7.673   3.015   1.00 9.57  ?  682  HOH A O   1 
HETATM 3405 O  O   . HOH G 6 .   ? -34.510 12.870  2.118   1.00 25.55 ?  683  HOH A O   1 
HETATM 3406 O  O   . HOH G 6 .   ? -33.545 17.175  -16.776 1.00 33.12 ?  684  HOH A O   1 
HETATM 3407 O  O   . HOH G 6 .   ? -8.518  20.947  -2.959  1.00 17.18 ?  685  HOH A O   1 
HETATM 3408 O  O   . HOH G 6 .   ? 4.083   -4.402  14.096  1.00 18.81 ?  686  HOH A O   1 
HETATM 3409 O  O   . HOH G 6 .   ? -24.716 -5.362  -18.801 1.00 31.19 ?  687  HOH A O   1 
HETATM 3410 O  O   . HOH G 6 .   ? -20.605 8.543   -21.275 1.00 14.44 ?  688  HOH A O   1 
HETATM 3411 O  O   . HOH G 6 .   ? -21.353 -21.520 6.064   1.00 26.95 ?  689  HOH A O   1 
HETATM 3412 O  O   . HOH G 6 .   ? -28.981 -20.738 16.890  1.00 28.74 ?  690  HOH A O   1 
HETATM 3413 O  O   . HOH G 6 .   ? -19.491 -13.962 3.486   1.00 15.60 ?  691  HOH A O   1 
HETATM 3414 O  O   . HOH G 6 .   ? -32.266 12.709  11.139  1.00 26.40 ?  692  HOH A O   1 
HETATM 3415 O  O   . HOH G 6 .   ? -32.583 2.951   -16.149 1.00 10.74 ?  693  HOH A O   1 
HETATM 3416 O  O   . HOH G 6 .   ? -24.268 -21.644 17.226  1.00 11.76 ?  694  HOH A O   1 
HETATM 3417 O  O   . HOH G 6 .   ? -9.668  9.399   16.546  1.00 13.68 ?  695  HOH A O   1 
HETATM 3418 O  O   . HOH G 6 .   ? -23.556 22.861  2.463   1.00 29.01 ?  696  HOH A O   1 
HETATM 3419 O  O   . HOH G 6 .   ? -18.790 -2.106  18.265  1.00 15.16 ?  697  HOH A O   1 
HETATM 3420 O  O   . HOH G 6 .   ? -17.043 -21.243 34.521  1.00 16.94 ?  698  HOH A O   1 
HETATM 3421 O  O   . HOH G 6 .   ? -29.526 -10.791 2.423   1.00 11.47 ?  699  HOH A O   1 
HETATM 3422 O  O   . HOH G 6 .   ? 1.641   5.443   6.248   1.00 34.02 ?  700  HOH A O   1 
HETATM 3423 O  O   . HOH G 6 .   ? -30.267 14.662  2.663   1.00 20.43 ?  701  HOH A O   1 
HETATM 3424 O  O   . HOH G 6 .   ? -39.653 7.227   -8.834  1.00 24.63 ?  702  HOH A O   1 
HETATM 3425 O  O   . HOH G 6 .   ? -20.521 0.538   -7.632  1.00 24.73 ?  703  HOH A O   1 
HETATM 3426 O  O   . HOH G 6 .   ? -1.387  -12.329 23.831  1.00 27.10 ?  704  HOH A O   1 
HETATM 3427 O  O   . HOH G 6 .   ? -29.415 1.171   -18.807 1.00 17.41 ?  705  HOH A O   1 
HETATM 3428 O  O   . HOH G 6 .   ? -20.293 2.275   -20.062 1.00 25.57 ?  706  HOH A O   1 
HETATM 3429 O  O   . HOH G 6 .   ? -38.194 6.979   -15.723 1.00 25.46 ?  707  HOH A O   1 
HETATM 3430 O  O   . HOH G 6 .   ? -6.728  -7.554  -6.463  1.00 17.60 ?  708  HOH A O   1 
HETATM 3431 O  O   . HOH G 6 .   ? -2.954  -5.507  -4.821  1.00 21.03 ?  709  HOH A O   1 
HETATM 3432 O  O   . HOH G 6 .   ? -23.678 -10.642 26.303  1.00 26.32 ?  710  HOH A O   1 
HETATM 3433 O  O   . HOH G 6 .   ? -10.063 -5.925  4.494   1.00 10.01 ?  711  HOH A O   1 
HETATM 3434 O  O   . HOH G 6 .   ? -9.971  -18.644 26.783  1.00 23.52 ?  712  HOH A O   1 
HETATM 3435 O  O   . HOH G 6 .   ? -15.229 5.855   28.265  1.00 20.49 ?  713  HOH A O   1 
HETATM 3436 O  O   . HOH G 6 .   ? -18.600 -5.754  13.787  1.00 9.37  ?  714  HOH A O   1 
HETATM 3437 O  O   . HOH G 6 .   ? -37.914 -9.093  4.056   1.00 22.33 ?  715  HOH A O   1 
HETATM 3438 O  O   . HOH G 6 .   ? -22.697 -27.659 27.005  1.00 17.79 ?  716  HOH A O   1 
HETATM 3439 O  O   . HOH G 6 .   ? -0.160  12.720  3.674   1.00 32.25 ?  717  HOH A O   1 
HETATM 3440 O  O   . HOH G 6 .   ? -0.673  8.638   8.042   1.00 19.98 ?  718  HOH A O   1 
HETATM 3441 O  O   . HOH G 6 .   ? -19.197 -25.604 3.013   1.00 25.10 ?  719  HOH A O   1 
HETATM 3442 O  O   . HOH G 6 .   ? -31.182 8.816   16.938  1.00 27.56 ?  720  HOH A O   1 
HETATM 3443 O  O   . HOH G 6 .   ? -26.219 -19.860 27.784  1.00 27.18 ?  721  HOH A O   1 
HETATM 3444 O  O   . HOH G 6 .   ? -7.205  -20.009 2.796   1.00 26.15 ?  722  HOH A O   1 
HETATM 3445 O  O   . HOH G 6 .   ? -3.882  -21.436 11.647  1.00 25.92 ?  723  HOH A O   1 
HETATM 3446 O  O   . HOH G 6 .   ? -37.079 5.231   3.285   1.00 19.42 ?  724  HOH A O   1 
HETATM 3447 O  O   . HOH G 6 .   ? -19.507 -9.511  -4.165  1.00 18.42 ?  725  HOH A O   1 
HETATM 3448 O  O   . HOH G 6 .   ? -3.142  8.519   19.686  1.00 24.58 ?  726  HOH A O   1 
HETATM 3449 O  O   . HOH G 6 .   ? -19.083 0.652   -4.178  1.00 7.81  ?  727  HOH A O   1 
HETATM 3450 O  O   . HOH G 6 .   ? -0.475  -5.203  6.954   1.00 12.75 ?  728  HOH A O   1 
HETATM 3451 O  O   . HOH G 6 .   ? -24.877 -4.647  18.486  1.00 17.95 ?  729  HOH A O   1 
HETATM 3452 O  O   . HOH G 6 .   ? -27.546 -9.146  -13.052 1.00 11.68 ?  730  HOH A O   1 
HETATM 3453 O  O   . HOH G 6 .   ? -14.110 24.087  13.212  1.00 17.08 ?  731  HOH A O   1 
HETATM 3454 O  O   . HOH G 6 .   ? -30.838 17.933  -14.744 1.00 24.81 ?  732  HOH A O   1 
HETATM 3455 O  O   . HOH G 6 .   ? -31.822 5.552   -16.699 1.00 13.37 ?  733  HOH A O   1 
HETATM 3456 O  O   . HOH G 6 .   ? -24.671 10.685  -25.390 1.00 29.32 ?  734  HOH A O   1 
HETATM 3457 O  O   . HOH G 6 .   ? -10.423 6.981   18.871  1.00 11.98 ?  735  HOH A O   1 
HETATM 3458 O  O   . HOH G 6 .   ? -7.876  -24.262 28.896  1.00 30.42 ?  736  HOH A O   1 
HETATM 3459 O  O   . HOH G 6 .   ? -6.165  10.029  -13.089 1.00 25.59 ?  737  HOH A O   1 
HETATM 3460 O  O   . HOH G 6 .   ? -13.527 -8.648  -3.927  1.00 19.32 ?  738  HOH A O   1 
HETATM 3461 O  O   . HOH G 6 .   ? -6.957  -7.772  -10.411 1.00 19.05 ?  739  HOH A O   1 
HETATM 3462 O  O   . HOH G 6 .   ? -37.171 13.611  -1.739  1.00 22.92 ?  740  HOH A O   1 
HETATM 3463 O  O   . HOH G 6 .   ? -3.511  -16.572 5.400   1.00 22.15 ?  741  HOH A O   1 
HETATM 3464 O  O   . HOH G 6 .   ? -2.087  -20.631 22.848  1.00 22.03 ?  742  HOH A O   1 
HETATM 3465 O  O   . HOH G 6 .   ? -12.287 -29.591 26.315  1.00 20.21 ?  743  HOH A O   1 
HETATM 3466 O  O   . HOH G 6 .   ? -1.377  -3.299  5.180   1.00 18.08 ?  744  HOH A O   1 
HETATM 3467 O  O   . HOH G 6 .   ? -12.662 -14.591 8.001   1.00 7.41  ?  745  HOH A O   1 
HETATM 3468 O  O   . HOH G 6 .   ? -15.921 -28.639 29.571  1.00 15.15 ?  746  HOH A O   1 
HETATM 3469 O  O   . HOH G 6 .   ? -7.954  0.410   0.728   1.00 9.02  ?  747  HOH A O   1 
HETATM 3470 O  O   . HOH G 6 .   ? -20.105 -1.788  2.882   1.00 10.32 ?  748  HOH A O   1 
HETATM 3471 O  O   . HOH G 6 .   ? -23.325 24.111  12.353  1.00 29.57 ?  749  HOH A O   1 
HETATM 3472 O  O   . HOH G 6 .   ? -1.912  0.636   -1.640  1.00 14.98 ?  750  HOH A O   1 
HETATM 3473 O  O   . HOH G 6 .   ? -13.492 -23.082 -1.207  1.00 19.74 ?  751  HOH A O   1 
HETATM 3474 O  O   . HOH G 6 .   ? -23.268 -17.089 9.532   1.00 10.77 ?  752  HOH A O   1 
HETATM 3475 O  O   . HOH G 6 .   ? -9.155  16.178  -4.329  1.00 17.41 ?  753  HOH A O   1 
HETATM 3476 O  O   . HOH G 6 .   ? -31.500 2.454   19.591  1.00 28.93 ?  754  HOH A O   1 
HETATM 3477 O  O   . HOH G 6 .   ? -17.113 -4.167  26.644  1.00 15.95 ?  755  HOH A O   1 
HETATM 3478 O  O   . HOH G 6 .   ? -7.982  12.854  -1.384  1.00 9.97  ?  756  HOH A O   1 
HETATM 3479 O  O   . HOH G 6 .   ? -1.111  5.965   28.963  1.00 19.68 ?  757  HOH A O   1 
HETATM 3480 O  O   . HOH G 6 .   ? -19.640 12.242  24.877  1.00 26.97 ?  758  HOH A O   1 
HETATM 3481 O  O   . HOH G 6 .   ? -23.603 17.939  15.162  1.00 12.20 ?  759  HOH A O   1 
HETATM 3482 O  O   . HOH G 6 .   ? 1.568   -1.713  6.893   1.00 24.35 ?  760  HOH A O   1 
HETATM 3483 O  O   . HOH G 6 .   ? -17.357 2.762   26.752  1.00 22.49 ?  761  HOH A O   1 
HETATM 3484 O  O   . HOH G 6 .   ? -16.991 -5.486  4.372   1.00 9.15  ?  762  HOH A O   1 
HETATM 3485 O  O   . HOH G 6 .   ? -17.995 20.839  -13.571 1.00 31.35 ?  763  HOH A O   1 
HETATM 3486 O  O   . HOH G 6 .   ? -20.792 -22.104 32.151  1.00 19.26 ?  764  HOH A O   1 
HETATM 3487 O  O   . HOH G 6 .   ? 4.680   0.918   12.264  1.00 19.92 ?  765  HOH A O   1 
HETATM 3488 O  O   . HOH G 6 .   ? -26.111 -25.287 32.603  1.00 18.50 ?  766  HOH A O   1 
HETATM 3489 O  O   . HOH G 6 .   ? -3.495  -20.177 14.112  1.00 17.92 ?  767  HOH A O   1 
HETATM 3490 O  O   . HOH G 6 .   ? -14.373 13.949  19.125  1.00 18.08 ?  768  HOH A O   1 
HETATM 3491 O  O   . HOH G 6 .   ? -14.752 16.288  -10.349 1.00 22.34 ?  769  HOH A O   1 
HETATM 3492 O  O   . HOH G 6 .   ? -27.039 20.777  4.028   1.00 18.35 ?  770  HOH A O   1 
HETATM 3493 O  O   . HOH G 6 .   ? -2.319  4.581   6.902   1.00 16.62 ?  771  HOH A O   1 
HETATM 3494 O  O   . HOH G 6 .   ? -32.936 15.059  5.489   1.00 27.38 ?  772  HOH A O   1 
HETATM 3495 O  O   . HOH G 6 .   ? -12.389 -15.553 32.063  1.00 17.75 ?  773  HOH A O   1 
HETATM 3496 O  O   . HOH G 6 .   ? -1.472  11.660  13.683  1.00 27.64 ?  774  HOH A O   1 
HETATM 3497 O  O   . HOH G 6 .   ? -4.818  -21.761 26.416  1.00 30.07 ?  775  HOH A O   1 
HETATM 3498 O  O   . HOH G 6 .   ? -13.743 6.276   -22.276 1.00 22.67 ?  776  HOH A O   1 
HETATM 3499 O  O   . HOH G 6 .   ? -31.489 -9.076  -18.413 1.00 25.61 ?  777  HOH A O   1 
HETATM 3500 O  O   . HOH G 6 .   ? 0.043   6.505   -3.416  1.00 28.77 ?  778  HOH A O   1 
HETATM 3501 O  O   . HOH G 6 .   ? -31.496 -14.419 28.375  1.00 35.14 ?  779  HOH A O   1 
HETATM 3502 O  O   . HOH G 6 .   ? -28.774 -7.454  -16.711 1.00 16.61 ?  780  HOH A O   1 
HETATM 3503 O  O   . HOH G 6 .   ? -13.236 20.675  -10.983 1.00 32.16 ?  781  HOH A O   1 
HETATM 3504 O  O   . HOH G 6 .   ? -20.840 -6.604  12.633  1.00 12.09 ?  782  HOH A O   1 
HETATM 3505 O  O   . HOH G 6 .   ? -37.254 -2.217  2.640   1.00 21.92 ?  783  HOH A O   1 
HETATM 3506 O  O   . HOH G 6 .   ? -28.217 -10.729 -17.129 1.00 21.56 ?  784  HOH A O   1 
HETATM 3507 O  O   . HOH G 6 .   ? -7.893  -4.408  5.296   1.00 9.38  ?  785  HOH A O   1 
HETATM 3508 O  O   . HOH G 6 .   ? -33.514 -10.316 11.095  1.00 25.72 ?  786  HOH A O   1 
HETATM 3509 O  O   . HOH G 6 .   ? -30.469 -16.200 -11.023 1.00 15.19 ?  787  HOH A O   1 
HETATM 3510 O  O   . HOH G 6 .   ? -22.566 1.070   -19.130 1.00 19.71 ?  788  HOH A O   1 
HETATM 3511 O  O   . HOH G 6 .   ? -13.947 22.416  15.380  1.00 28.23 ?  789  HOH A O   1 
HETATM 3512 O  O   . HOH G 6 .   ? -23.301 -2.873  -21.012 1.00 31.04 ?  790  HOH A O   1 
HETATM 3513 O  O   . HOH G 6 .   ? -5.556  6.388   0.487   1.00 11.33 ?  791  HOH A O   1 
HETATM 3514 O  O   . HOH G 6 .   ? -26.018 -7.164  3.139   1.00 10.23 ?  792  HOH A O   1 
HETATM 3515 O  O   . HOH G 6 .   ? -35.863 -3.168  -6.126  1.00 28.61 ?  793  HOH A O   1 
HETATM 3516 O  O   . HOH G 6 .   ? -22.772 24.549  18.384  1.00 32.01 ?  794  HOH A O   1 
HETATM 3517 O  O   . HOH G 6 .   ? -38.646 13.413  -14.356 1.00 25.71 ?  795  HOH A O   1 
HETATM 3518 O  O   . HOH G 6 .   ? -21.755 -5.753  18.700  1.00 17.83 ?  796  HOH A O   1 
HETATM 3519 O  O   . HOH G 6 .   ? -19.736 5.116   -24.366 1.00 13.26 ?  797  HOH A O   1 
HETATM 3520 O  O   . HOH G 6 .   ? -23.135 -7.569  16.806  1.00 13.51 ?  798  HOH A O   1 
HETATM 3521 O  O   . HOH G 6 .   ? -34.977 2.035   8.186   1.00 15.20 ?  799  HOH A O   1 
HETATM 3522 O  O   . HOH G 6 .   ? -7.413  10.718  21.190  1.00 21.78 ?  800  HOH A O   1 
HETATM 3523 O  O   . HOH G 6 .   ? -28.750 -8.869  22.224  1.00 24.25 ?  801  HOH A O   1 
HETATM 3524 O  O   . HOH G 6 .   ? -28.455 7.352   22.570  1.00 22.20 ?  802  HOH A O   1 
HETATM 3525 O  O   . HOH G 6 .   ? -30.749 -13.266 2.867   1.00 12.43 ?  803  HOH A O   1 
HETATM 3526 O  O   . HOH G 6 .   ? -15.850 14.696  -12.528 1.00 23.30 ?  804  HOH A O   1 
HETATM 3527 O  O   . HOH G 6 .   ? -7.211  -12.500 4.001   1.00 9.40  ?  805  HOH A O   1 
HETATM 3528 O  O   . HOH G 6 .   ? -4.187  -7.199  0.049   1.00 16.42 ?  806  HOH A O   1 
HETATM 3529 O  O   . HOH G 6 .   ? -13.495 -28.345 32.803  1.00 25.49 ?  807  HOH A O   1 
HETATM 3530 O  O   . HOH G 6 .   ? -33.257 7.270   -15.146 1.00 12.67 ?  808  HOH A O   1 
HETATM 3531 O  O   . HOH G 6 .   ? -22.640 -15.151 -5.328  1.00 25.65 ?  809  HOH A O   1 
HETATM 3532 O  O   . HOH G 6 .   ? -5.545  7.320   -10.198 1.00 31.64 ?  810  HOH A O   1 
HETATM 3533 O  O   . HOH G 6 .   ? -4.798  3.520   7.366   1.00 14.92 ?  811  HOH A O   1 
HETATM 3534 O  O   . HOH G 6 .   ? -3.966  2.473   -9.149  1.00 16.93 ?  812  HOH A O   1 
HETATM 3535 O  O   . HOH G 6 .   ? -21.304 17.003  -20.029 1.00 30.13 ?  813  HOH A O   1 
HETATM 3536 O  O   . HOH G 6 .   ? -7.154  9.421   30.683  1.00 28.97 ?  814  HOH A O   1 
HETATM 3537 O  O   . HOH G 6 .   ? -20.291 -30.877 29.056  1.00 23.52 ?  815  HOH A O   1 
HETATM 3538 O  O   . HOH G 6 .   ? -16.358 7.182   -24.729 1.00 15.13 ?  816  HOH A O   1 
HETATM 3539 O  O   . HOH G 6 .   ? -13.103 1.129   24.430  1.00 11.30 ?  817  HOH A O   1 
HETATM 3540 O  O   . HOH G 6 .   ? -4.981  -0.359  9.414   1.00 12.10 ?  818  HOH A O   1 
HETATM 3541 O  O   . HOH G 6 .   ? -20.602 -34.064 20.931  1.00 28.30 ?  819  HOH A O   1 
HETATM 3542 O  O   . HOH G 6 .   ? 2.351   -3.785  15.988  1.00 20.85 ?  820  HOH A O   1 
HETATM 3543 O  O   . HOH G 6 .   ? -26.261 -17.023 29.914  1.00 27.08 ?  821  HOH A O   1 
HETATM 3544 O  O   . HOH G 6 .   ? -21.252 -10.998 14.401  1.00 10.71 ?  822  HOH A O   1 
HETATM 3545 O  O   . HOH G 6 .   ? -20.866 -0.656  22.244  1.00 22.88 ?  823  HOH A O   1 
HETATM 3546 O  O   . HOH G 6 .   ? -14.307 -17.462 2.864   1.00 13.25 ?  824  HOH A O   1 
HETATM 3547 O  O   . HOH G 6 .   ? -18.398 -27.741 6.685   1.00 23.61 ?  825  HOH A O   1 
HETATM 3548 O  O   . HOH G 6 .   ? -17.704 -16.245 31.516  1.00 19.76 ?  826  HOH A O   1 
HETATM 3549 O  O   . HOH G 6 .   ? -20.432 20.050  -1.665  1.00 18.92 ?  827  HOH A O   1 
HETATM 3550 O  O   . HOH G 6 .   ? -1.462  1.002   31.954  1.00 23.35 ?  828  HOH A O   1 
HETATM 3551 O  O   . HOH G 6 .   ? -21.204 -24.226 7.233   1.00 21.20 ?  829  HOH A O   1 
HETATM 3552 O  O   . HOH G 6 .   ? -26.092 18.894  8.443   1.00 17.99 ?  830  HOH A O   1 
HETATM 3553 O  O   . HOH G 6 .   ? -27.626 -16.346 3.351   1.00 26.17 ?  831  HOH A O   1 
HETATM 3554 O  O   . HOH G 6 .   ? -7.660  -8.895  -3.072  1.00 16.48 ?  832  HOH A O   1 
HETATM 3555 O  O   . HOH G 6 .   ? -10.328 21.987  10.645  1.00 14.28 ?  833  HOH A O   1 
HETATM 3556 O  O   . HOH G 6 .   ? -9.971  19.012  13.310  1.00 21.47 ?  834  HOH A O   1 
HETATM 3557 O  O   . HOH G 6 .   ? -37.875 -1.376  -9.511  1.00 28.79 ?  835  HOH A O   1 
HETATM 3558 O  O   . HOH G 6 .   ? -27.647 7.907   4.043   1.00 9.23  ?  836  HOH A O   1 
HETATM 3559 O  O   . HOH G 6 .   ? -26.686 18.246  -8.800  1.00 26.55 ?  837  HOH A O   1 
HETATM 3560 O  O   . HOH G 6 .   ? -8.038  -21.633 27.426  1.00 20.99 ?  838  HOH A O   1 
HETATM 3561 O  O   . HOH G 6 .   ? -9.346  -3.097  27.319  1.00 12.56 ?  839  HOH A O   1 
HETATM 3562 O  O   . HOH G 6 .   ? -30.720 12.822  0.965   1.00 26.42 ?  840  HOH A O   1 
HETATM 3563 O  O   . HOH G 6 .   ? 3.500   -19.006 14.098  1.00 25.10 ?  841  HOH A O   1 
HETATM 3564 O  O   . HOH G 6 .   ? -33.270 16.927  10.072  1.00 35.99 ?  842  HOH A O   1 
HETATM 3565 O  O   . HOH G 6 .   ? -29.924 18.827  11.799  1.00 26.67 ?  843  HOH A O   1 
HETATM 3566 O  O   . HOH G 6 .   ? -6.053  -11.098 -3.222  1.00 19.11 ?  844  HOH A O   1 
HETATM 3567 O  O   . HOH G 6 .   ? -4.488  7.228   4.985   1.00 21.74 ?  845  HOH A O   1 
HETATM 3568 O  O   . HOH G 6 .   ? -35.532 -7.252  -2.766  1.00 18.35 ?  846  HOH A O   1 
HETATM 3569 O  O   . HOH G 6 .   ? -5.872  10.439  -6.353  1.00 26.46 ?  847  HOH A O   1 
HETATM 3570 O  O   . HOH G 6 .   ? -12.044 -7.954  -14.927 1.00 23.07 ?  848  HOH A O   1 
HETATM 3571 O  O   . HOH G 6 .   ? -15.490 -4.990  -4.901  1.00 13.89 ?  849  HOH A O   1 
HETATM 3572 O  O   . HOH G 6 .   ? -6.008  -3.571  3.606   1.00 12.20 ?  850  HOH A O   1 
HETATM 3573 O  O   . HOH G 6 .   ? -30.930 9.124   7.180   1.00 17.61 ?  851  HOH A O   1 
HETATM 3574 O  O   . HOH G 6 .   ? -5.970  -21.218 10.003  1.00 19.76 ?  852  HOH A O   1 
HETATM 3575 O  O   . HOH G 6 .   ? -13.908 -6.151  -2.933  1.00 13.29 ?  853  HOH A O   1 
HETATM 3576 O  O   . HOH G 6 .   ? -28.711 18.296  9.176   1.00 19.30 ?  854  HOH A O   1 
HETATM 3577 O  O   . HOH G 6 .   ? -19.065 1.580   23.041  1.00 18.70 ?  855  HOH A O   1 
HETATM 3578 O  O   . HOH G 6 .   ? -27.469 -17.773 5.501   1.00 24.20 ?  856  HOH A O   1 
HETATM 3579 O  O   . HOH G 6 .   ? -17.013 -31.616 25.802  1.00 27.84 ?  857  HOH A O   1 
HETATM 3580 O  O   . HOH G 6 .   ? 2.376   -4.945  7.639   1.00 24.57 ?  858  HOH A O   1 
HETATM 3581 O  O   . HOH G 6 .   ? -0.612  -3.080  1.398   1.00 27.33 ?  859  HOH A O   1 
HETATM 3582 O  O   . HOH G 6 .   ? -13.236 12.347  20.998  1.00 16.60 ?  860  HOH A O   1 
HETATM 3583 O  O   . HOH G 6 .   ? -5.682  -0.982  -22.305 1.00 31.73 ?  861  HOH A O   1 
HETATM 3584 O  O   . HOH G 6 .   ? -21.064 0.942   1.462   1.00 8.44  ?  862  HOH A O   1 
HETATM 3585 O  O   . HOH G 6 .   ? -31.208 8.771   9.992   1.00 20.88 ?  863  HOH A O   1 
HETATM 3586 O  O   . HOH G 6 .   ? -0.599  17.300  3.694   1.00 28.29 ?  864  HOH A O   1 
HETATM 3587 O  O   . HOH G 6 .   ? -30.266 -2.357  -0.529  1.00 16.54 ?  865  HOH A O   1 
HETATM 3588 O  O   . HOH G 6 .   ? -4.802  1.337   5.476   1.00 12.05 ?  866  HOH A O   1 
HETATM 3589 O  O   . HOH G 6 .   ? -0.627  -8.362  23.653  1.00 16.56 ?  867  HOH A O   1 
HETATM 3590 O  O   . HOH G 6 .   ? -21.216 11.773  21.118  1.00 17.39 ?  868  HOH A O   1 
HETATM 3591 O  O   . HOH G 6 .   ? 5.625   -17.204 15.945  1.00 20.98 ?  869  HOH A O   1 
HETATM 3592 O  O   . HOH G 6 .   ? -1.817  -23.708 19.578  1.00 15.50 ?  870  HOH A O   1 
HETATM 3593 O  O   . HOH G 6 .   ? 1.686   -7.298  9.212   1.00 16.22 ?  871  HOH A O   1 
HETATM 3594 O  O   . HOH G 6 .   ? -27.074 4.901   -22.981 1.00 19.16 ?  872  HOH A O   1 
HETATM 3595 O  O   . HOH G 6 .   ? -28.285 20.194  -15.186 1.00 27.76 ?  873  HOH A O   1 
HETATM 3596 O  O   . HOH G 6 .   ? -33.924 -3.655  -16.668 1.00 13.27 ?  874  HOH A O   1 
HETATM 3597 O  O   . HOH G 6 .   ? -7.164  9.647   15.421  1.00 14.78 ?  875  HOH A O   1 
HETATM 3598 O  O   . HOH G 6 .   ? -2.396  -23.335 22.305  1.00 16.88 ?  876  HOH A O   1 
HETATM 3599 O  O   . HOH G 6 .   ? -11.375 24.563  1.716   1.00 18.16 ?  877  HOH A O   1 
HETATM 3600 O  O   . HOH G 6 .   ? 2.517   -11.541 8.396   1.00 32.28 ?  878  HOH A O   1 
HETATM 3601 O  O   . HOH G 6 .   ? -23.820 -26.484 15.581  1.00 28.47 ?  879  HOH A O   1 
HETATM 3602 O  O   . HOH G 6 .   ? -20.018 26.145  10.031  1.00 19.95 ?  880  HOH A O   1 
HETATM 3603 O  O   . HOH G 6 .   ? -20.431 24.851  14.745  1.00 23.85 ?  881  HOH A O   1 
HETATM 3604 O  O   . HOH G 6 .   ? -25.772 -11.246 -7.055  1.00 15.27 ?  882  HOH A O   1 
HETATM 3605 O  O   . HOH G 6 .   ? -9.594  -5.310  -21.688 1.00 26.09 ?  883  HOH A O   1 
HETATM 3606 O  O   . HOH G 6 .   ? -17.791 -11.323 -2.997  1.00 14.09 ?  884  HOH A O   1 
HETATM 3607 O  O   . HOH G 6 .   ? -8.138  1.998   -13.011 1.00 18.43 ?  885  HOH A O   1 
HETATM 3608 O  O   . HOH G 6 .   ? -40.303 7.775   -4.203  1.00 26.26 ?  886  HOH A O   1 
HETATM 3609 O  O   . HOH G 6 .   ? -8.523  -11.382 -5.329  1.00 27.01 ?  887  HOH A O   1 
HETATM 3610 O  O   . HOH G 6 .   ? -18.667 12.284  -27.347 1.00 20.95 ?  888  HOH A O   1 
HETATM 3611 O  O   . HOH G 6 .   ? -0.897  5.015   31.534  1.00 26.94 ?  889  HOH A O   1 
HETATM 3612 O  O   . HOH G 6 .   ? -15.608 -10.030 3.279   1.00 8.46  ?  890  HOH A O   1 
HETATM 3613 O  O   . HOH G 6 .   ? -13.896 -31.204 4.590   1.00 21.25 ?  891  HOH A O   1 
HETATM 3614 O  O   . HOH G 6 .   ? -17.579 -1.324  26.986  1.00 24.82 ?  892  HOH A O   1 
HETATM 3615 O  O   . HOH G 6 .   ? -18.238 -3.972  11.616  1.00 9.08  ?  893  HOH A O   1 
HETATM 3616 O  O   . HOH G 6 .   ? -13.931 -6.400  -17.893 1.00 19.55 ?  894  HOH A O   1 
HETATM 3617 O  O   . HOH G 6 .   ? -34.093 10.882  7.054   1.00 26.74 ?  895  HOH A O   1 
HETATM 3618 O  O   . HOH G 6 .   ? -29.752 2.319   -16.335 1.00 12.13 ?  896  HOH A O   1 
HETATM 3619 O  O   . HOH G 6 .   ? -15.666 -2.245  -3.652  1.00 10.12 ?  897  HOH A O   1 
HETATM 3620 O  O   . HOH G 6 .   ? -2.519  17.465  5.189   1.00 20.66 ?  898  HOH A O   1 
HETATM 3621 O  O   . HOH G 6 .   ? -7.203  -13.386 25.202  1.00 15.53 ?  899  HOH A O   1 
HETATM 3622 O  O   . HOH G 6 .   ? -13.439 -28.773 20.117  1.00 19.52 ?  900  HOH A O   1 
HETATM 3623 O  O   . HOH G 6 .   ? 3.657   -11.498 23.423  1.00 29.99 ?  901  HOH A O   1 
HETATM 3624 O  O   . HOH G 6 .   ? -35.520 -2.764  -2.401  1.00 26.93 ?  902  HOH A O   1 
HETATM 3625 O  O   . HOH G 6 .   ? -21.800 -12.543 2.719   1.00 14.71 ?  903  HOH A O   1 
HETATM 3626 O  O   . HOH G 6 .   ? -24.062 5.146   -0.740  1.00 9.21  ?  904  HOH A O   1 
HETATM 3627 O  O   . HOH G 6 .   ? -7.674  6.054   -14.187 1.00 20.10 ?  905  HOH A O   1 
HETATM 3628 O  O   . HOH G 6 .   ? -5.257  23.061  -1.831  1.00 27.31 ?  906  HOH A O   1 
HETATM 3629 O  O   . HOH G 6 .   ? -10.231 -0.615  28.480  1.00 20.67 ?  907  HOH A O   1 
HETATM 3630 O  O   . HOH G 6 .   ? -31.642 1.798   14.624  1.00 17.87 ?  908  HOH A O   1 
HETATM 3631 O  O   . HOH G 6 .   ? -28.398 -3.822  17.000  1.00 26.84 ?  909  HOH A O   1 
HETATM 3632 O  O   . HOH G 6 .   ? -15.000 -14.858 0.193   1.00 25.16 ?  910  HOH A O   1 
HETATM 3633 O  O   . HOH G 6 .   ? 2.667   6.201   13.788  1.00 33.57 ?  911  HOH A O   1 
HETATM 3634 O  O   . HOH G 6 .   ? -28.341 8.524   6.726   1.00 10.76 ?  912  HOH A O   1 
HETATM 3635 O  O   . HOH G 6 .   ? 2.215   -16.199 9.206   1.00 28.98 ?  913  HOH A O   1 
HETATM 3636 O  O   . HOH G 6 .   ? -35.028 1.729   -5.449  1.00 20.60 ?  914  HOH A O   1 
HETATM 3637 O  O   . HOH G 6 .   ? -22.952 11.094  -23.950 1.00 25.56 ?  915  HOH A O   1 
HETATM 3638 O  O   . HOH G 6 .   ? -6.261  -0.472  -12.642 1.00 21.76 ?  916  HOH A O   1 
HETATM 3639 O  O   . HOH G 6 .   ? -8.498  -1.667  5.680   1.00 10.20 ?  917  HOH A O   1 
HETATM 3640 O  O   . HOH G 6 .   ? -21.313 22.031  0.124   1.00 29.45 ?  918  HOH A O   1 
HETATM 3641 O  O   . HOH G 6 .   ? -25.156 5.508   23.063  1.00 20.17 ?  919  HOH A O   1 
HETATM 3642 O  O   . HOH G 6 .   ? -5.304  12.275  -5.230  1.00 23.96 ?  920  HOH A O   1 
HETATM 3643 O  O   . HOH G 6 .   ? -1.215  9.199   12.617  1.00 17.45 ?  921  HOH A O   1 
HETATM 3644 O  O   . HOH G 6 .   ? -1.080  20.549  3.171   1.00 25.13 ?  922  HOH A O   1 
HETATM 3645 O  O   . HOH G 6 .   ? -19.502 17.708  20.835  1.00 34.32 ?  923  HOH A O   1 
HETATM 3646 O  O   . HOH G 6 .   ? -28.003 -23.712 25.820  1.00 36.68 ?  924  HOH A O   1 
HETATM 3647 O  O   . HOH G 6 .   ? -16.064 -28.384 1.888   1.00 15.31 ?  925  HOH A O   1 
HETATM 3648 O  O   . HOH G 6 .   ? -29.495 -18.465 12.825  1.00 30.71 ?  926  HOH A O   1 
HETATM 3649 O  O   . HOH G 6 .   ? -24.400 -7.722  -17.668 1.00 29.63 ?  927  HOH A O   1 
HETATM 3650 O  O   . HOH G 6 .   ? -21.477 21.113  -4.141  1.00 20.90 ?  928  HOH A O   1 
HETATM 3651 O  O   . HOH G 6 .   ? -8.528  -0.885  -1.730  1.00 8.84  ?  929  HOH A O   1 
HETATM 3652 O  O   . HOH G 6 .   ? -13.886 -9.660  31.223  1.00 22.61 ?  930  HOH A O   1 
HETATM 3653 O  O   . HOH G 6 .   ? -29.880 -18.275 15.547  1.00 32.35 ?  931  HOH A O   1 
HETATM 3654 O  O   . HOH G 6 .   ? -7.496  22.389  1.846   1.00 24.23 ?  932  HOH A O   1 
HETATM 3655 O  O   . HOH G 6 .   ? -18.721 -5.455  9.304   1.00 10.06 ?  933  HOH A O   1 
HETATM 3656 O  O   . HOH G 6 .   ? -17.346 -4.167  6.955   1.00 7.93  ?  934  HOH A O   1 
HETATM 3657 O  O   . HOH G 6 .   ? -20.506 21.452  -7.499  1.00 29.22 ?  935  HOH A O   1 
HETATM 3658 O  O   . HOH G 6 .   ? 2.894   -7.650  16.540  1.00 27.12 ?  936  HOH A O   1 
HETATM 3659 O  O   . HOH G 6 .   ? -34.791 -4.926  -4.328  1.00 17.10 ?  937  HOH A O   1 
HETATM 3660 O  O   . HOH G 6 .   ? -41.202 -14.828 21.954  1.00 36.58 ?  938  HOH A O   1 
HETATM 3661 O  O   . HOH G 6 .   ? -40.194 11.433  -1.237  1.00 28.12 ?  939  HOH A O   1 
HETATM 3662 O  O   . HOH G 6 .   ? 0.736   0.516   28.909  1.00 14.95 ?  940  HOH A O   1 
HETATM 3663 O  O   . HOH G 6 .   ? -29.756 16.125  -4.441  1.00 27.25 ?  941  HOH A O   1 
HETATM 3664 O  O   . HOH G 6 .   ? -20.371 -8.339  -13.500 1.00 24.16 ?  942  HOH A O   1 
HETATM 3665 O  O   . HOH G 6 .   ? -18.334 -7.715  -14.953 1.00 27.30 ?  943  HOH A O   1 
HETATM 3666 O  O   . HOH G 6 .   ? -3.999  -27.300 24.520  1.00 22.51 ?  944  HOH A O   1 
HETATM 3667 O  O   . HOH G 6 .   ? -5.349  -3.719  29.829  1.00 12.45 ?  945  HOH A O   1 
HETATM 3668 O  O   . HOH G 6 .   ? -5.380  8.382   -7.536  1.00 19.20 ?  946  HOH A O   1 
HETATM 3669 O  O   . HOH G 6 .   ? -6.658  4.140   -12.426 1.00 23.84 ?  947  HOH A O   1 
HETATM 3670 O  O   . HOH G 6 .   ? -33.238 -15.876 14.793  1.00 37.18 ?  948  HOH A O   1 
HETATM 3671 O  O   . HOH G 6 .   ? 3.216   -16.756 20.733  1.00 30.54 ?  949  HOH A O   1 
HETATM 3672 O  O   . HOH G 6 .   ? -1.564  -23.779 13.054  1.00 36.35 ?  950  HOH A O   1 
HETATM 3673 O  O   . HOH G 6 .   ? -6.914  -15.200 27.500  1.00 18.49 ?  951  HOH A O   1 
HETATM 3674 O  O   . HOH G 6 .   ? -1.345  -3.839  -8.523  1.00 16.53 ?  952  HOH A O   1 
HETATM 3675 O  O   . HOH G 6 .   ? -12.567 8.606   -19.662 1.00 23.37 ?  953  HOH A O   1 
HETATM 3676 O  O   . HOH G 6 .   ? -0.428  10.661  1.398   1.00 27.31 ?  954  HOH A O   1 
HETATM 3677 O  O   . HOH G 6 .   ? -26.685 -17.627 1.256   1.00 25.67 ?  955  HOH A O   1 
HETATM 3678 O  O   . HOH G 6 .   ? -0.772  10.498  -5.560  1.00 32.95 ?  956  HOH A O   1 
HETATM 3679 O  O   . HOH G 6 .   ? -27.341 19.906  17.647  1.00 21.24 ?  957  HOH A O   1 
HETATM 3680 O  O   . HOH G 6 .   ? -9.334  22.537  -7.360  1.00 27.68 ?  958  HOH A O   1 
HETATM 3681 O  O   . HOH G 6 .   ? 0.573   2.941   27.752  1.00 14.86 ?  959  HOH A O   1 
HETATM 3682 O  O   . HOH G 6 .   ? -8.723  -14.734 -6.541  1.00 34.61 ?  960  HOH A O   1 
HETATM 3683 O  O   . HOH G 6 .   ? -0.238  -21.086 19.056  1.00 31.42 ?  961  HOH A O   1 
HETATM 3684 O  O   . HOH G 6 .   ? -0.833  15.243  7.165   1.00 35.32 ?  962  HOH A O   1 
HETATM 3685 O  O   . HOH G 6 .   ? -7.574  -13.325 1.024   1.00 7.94  ?  963  HOH A O   1 
HETATM 3686 O  O   . HOH G 6 .   ? -16.511 1.702   24.356  1.00 21.33 ?  964  HOH A O   1 
HETATM 3687 O  O   . HOH G 6 .   ? -2.458  14.744  16.861  1.00 29.39 ?  965  HOH A O   1 
HETATM 3688 O  O   . HOH G 6 .   ? -33.800 5.416   11.369  1.00 27.33 ?  966  HOH A O   1 
HETATM 3689 O  O   . HOH G 6 .   ? -10.604 23.952  -1.301  1.00 30.06 ?  967  HOH A O   1 
HETATM 3690 O  O   . HOH G 6 .   ? -37.769 -3.867  -16.882 1.00 29.47 ?  968  HOH A O   1 
HETATM 3691 O  O   . HOH G 6 .   ? -6.445  15.775  7.119   1.00 16.03 ?  969  HOH A O   1 
HETATM 3692 O  O   . HOH G 6 .   ? -16.362 -28.699 8.149   1.00 21.05 ?  970  HOH A O   1 
HETATM 3693 O  O   . HOH G 6 .   ? -10.823 12.976  22.112  1.00 30.38 ?  971  HOH A O   1 
HETATM 3694 O  O   . HOH G 6 .   ? -2.702  -4.699  -2.094  1.00 25.91 ?  972  HOH A O   1 
HETATM 3695 O  O   . HOH G 6 .   ? -10.872 13.897  -18.131 1.00 24.76 ?  973  HOH A O   1 
HETATM 3696 O  O   . HOH G 6 .   ? -12.103 15.588  -11.159 1.00 29.52 ?  974  HOH A O   1 
HETATM 3697 O  O   . HOH G 6 .   ? -24.982 -16.792 6.850   1.00 10.52 ?  975  HOH A O   1 
HETATM 3698 O  O   . HOH G 6 .   ? -15.146 9.928   25.765  1.00 29.16 ?  976  HOH A O   1 
HETATM 3699 O  O   . HOH G 6 .   ? -23.620 -20.189 7.100   1.00 30.65 ?  977  HOH A O   1 
HETATM 3700 O  O   . HOH G 6 .   ? -3.461  14.844  8.063   1.00 28.01 ?  978  HOH A O   1 
HETATM 3701 O  O   . HOH G 6 .   ? -0.991  -15.143 24.126  1.00 32.54 ?  979  HOH A O   1 
HETATM 3702 O  O   . HOH G 6 .   ? -15.475 18.750  -11.307 1.00 25.54 ?  980  HOH A O   1 
HETATM 3703 O  O   . HOH G 6 .   ? -16.175 -15.545 2.656   1.00 27.28 ?  981  HOH A O   1 
HETATM 3704 O  O   . HOH G 6 .   ? -15.272 -7.884  -6.159  1.00 32.69 ?  982  HOH A O   1 
HETATM 3705 O  O   . HOH G 6 .   ? -9.218  7.198   -17.996 1.00 30.32 ?  983  HOH A O   1 
HETATM 3706 O  O   . HOH G 6 .   ? -4.383  -2.181  5.427   1.00 15.83 ?  984  HOH A O   1 
HETATM 3707 O  O   . HOH G 6 .   ? -37.534 3.064   4.970   1.00 26.33 ?  985  HOH A O   1 
HETATM 3708 O  O   . HOH G 6 .   ? -23.716 -13.394 -7.082  1.00 28.69 ?  986  HOH A O   1 
HETATM 3709 O  O   . HOH G 6 .   ? -24.633 -18.897 2.706   1.00 26.00 ?  987  HOH A O   1 
HETATM 3710 O  O   . HOH G 6 .   ? -18.460 -15.634 1.481   1.00 26.16 ?  988  HOH A O   1 
HETATM 3711 O  O   . HOH G 6 .   ? -38.024 -4.537  4.177   1.00 24.70 ?  989  HOH A O   1 
HETATM 3712 O  O   . HOH G 6 .   ? -1.338  -2.260  -1.130  1.00 20.04 ?  990  HOH A O   1 
HETATM 3713 O  O   . HOH G 6 .   ? -3.807  -4.399  -12.691 1.00 25.56 ?  991  HOH A O   1 
HETATM 3714 O  O   . HOH G 6 .   ? -34.761 16.393  -12.751 1.00 16.40 ?  992  HOH A O   1 
HETATM 3715 O  O   . HOH G 6 .   ? -16.746 -19.840 2.832   1.00 26.65 ?  993  HOH A O   1 
HETATM 3716 O  O   . HOH G 6 .   ? -19.929 26.581  12.848  1.00 24.85 ?  994  HOH A O   1 
HETATM 3717 O  O   . HOH G 6 .   ? -31.089 5.874   -19.331 1.00 16.21 ?  995  HOH A O   1 
HETATM 3718 O  O   . HOH G 6 .   ? -7.997  -28.699 25.675  1.00 41.49 ?  996  HOH A O   1 
HETATM 3719 O  O   . HOH G 6 .   ? -1.827  8.709   29.326  1.00 26.03 ?  997  HOH A O   1 
HETATM 3720 O  O   . HOH G 6 .   ? 1.950   -5.707  17.774  1.00 19.70 ?  998  HOH A O   1 
HETATM 3721 O  O   . HOH G 6 .   ? -6.948  15.583  -5.875  1.00 29.17 ?  999  HOH A O   1 
HETATM 3722 O  O   . HOH G 6 .   ? -14.960 -10.864 -2.902  1.00 19.59 ?  1000 HOH A O   1 
HETATM 3723 O  O   . HOH G 6 .   ? -27.758 20.208  12.535  1.00 26.14 ?  1001 HOH A O   1 
HETATM 3724 O  O   . HOH G 6 .   ? -12.735 11.813  25.948  1.00 34.89 ?  1002 HOH A O   1 
HETATM 3725 O  O   . HOH G 6 .   ? -6.471  19.242  -4.925  1.00 30.75 ?  1003 HOH A O   1 
HETATM 3726 O  O   . HOH G 6 .   ? -35.423 9.820   4.805   1.00 28.25 ?  1004 HOH A O   1 
HETATM 3727 O  O   . HOH G 6 .   ? -21.847 18.543  23.310  1.00 28.64 ?  1005 HOH A O   1 
HETATM 3728 O  O   . HOH G 6 .   ? 3.512   5.107   11.741  1.00 29.54 ?  1006 HOH A O   1 
HETATM 3729 O  O   . HOH G 6 .   ? -20.348 -3.441  22.699  1.00 25.98 ?  1007 HOH A O   1 
HETATM 3730 O  O   . HOH G 6 .   ? -3.755  7.238   2.295   1.00 14.42 ?  1008 HOH A O   1 
HETATM 3731 O  O   . HOH G 6 .   ? -27.952 6.190   -25.234 1.00 29.77 ?  1009 HOH A O   1 
HETATM 3732 O  O   . HOH G 6 .   ? -26.998 -6.333  18.608  1.00 27.35 ?  1010 HOH A O   1 
HETATM 3733 O  O   . HOH G 6 .   ? -34.590 18.424  -14.713 1.00 24.97 ?  1011 HOH A O   1 
HETATM 3734 O  O   . HOH G 6 .   ? -19.449 -4.042  4.411   1.00 13.43 ?  1012 HOH A O   1 
HETATM 3735 O  O   . HOH G 6 .   ? -17.394 -4.839  29.306  1.00 23.07 ?  1013 HOH A O   1 
HETATM 3736 O  O   . HOH G 6 .   ? -15.780 -30.679 31.091  1.00 29.46 ?  1014 HOH A O   1 
HETATM 3737 O  O   . HOH G 6 .   ? -23.231 -5.981  23.592  1.00 29.90 ?  1015 HOH A O   1 
HETATM 3738 O  O   . HOH G 6 .   ? 6.074   -18.161 18.403  1.00 32.31 ?  1016 HOH A O   1 
HETATM 3739 O  O   . HOH G 6 .   ? -1.187  -4.487  -11.300 1.00 29.36 ?  1017 HOH A O   1 
HETATM 3740 O  O   . HOH G 6 .   ? -39.450 -4.146  6.676   1.00 31.05 ?  1018 HOH A O   1 
HETATM 3741 O  O   . HOH G 6 .   ? -13.650 -30.194 28.422  1.00 25.93 ?  1019 HOH A O   1 
HETATM 3742 O  O   . HOH G 6 .   ? -2.053  -0.127  5.140   1.00 9.35  ?  1020 HOH A O   1 
HETATM 3743 O  O   . HOH G 6 .   ? -29.185 -4.866  -17.467 1.00 19.08 ?  1021 HOH A O   1 
HETATM 3744 O  O   . HOH G 6 .   ? -9.227  -9.297  -11.113 1.00 28.97 ?  1022 HOH A O   1 
HETATM 3745 O  O   . HOH G 6 .   ? -9.742  -30.608 26.306  1.00 32.49 ?  1023 HOH A O   1 
HETATM 3746 O  O   . HOH G 6 .   ? -28.768 21.390  15.362  1.00 34.69 ?  1024 HOH A O   1 
HETATM 3747 O  O   . HOH G 6 .   ? -29.714 3.753   -20.157 1.00 26.10 ?  1025 HOH A O   1 
HETATM 3748 O  O   . HOH G 6 .   ? -8.699  -30.338 20.843  1.00 29.38 ?  1026 HOH A O   1 
HETATM 3749 O  O   . HOH G 6 .   ? -34.720 13.844  7.130   1.00 35.42 ?  1027 HOH A O   1 
HETATM 3750 O  O   . HOH G 6 .   ? -2.288  7.329   6.370   1.00 23.65 ?  1028 HOH A O   1 
HETATM 3751 O  O   . HOH G 6 .   ? -7.531  -1.178  3.097   1.00 11.16 ?  1029 HOH A O   1 
HETATM 3752 O  O   . HOH G 6 .   ? 4.603   -7.063  13.951  1.00 26.10 ?  1030 HOH A O   1 
HETATM 3753 O  O   . HOH G 6 .   ? -20.288 -7.910  -10.670 1.00 23.27 ?  1031 HOH A O   1 
HETATM 3754 O  O   . HOH G 6 .   ? -17.715 -8.933  -6.341  1.00 25.29 ?  1032 HOH A O   1 
HETATM 3755 O  O   . HOH G 6 .   ? -18.282 -6.993  30.620  1.00 28.55 ?  1033 HOH A O   1 
HETATM 3756 O  O   . HOH G 6 .   ? -19.197 -34.590 27.454  1.00 33.43 ?  1034 HOH A O   1 
HETATM 3757 O  O   . HOH G 6 .   ? -27.453 -25.258 28.895  1.00 30.35 ?  1035 HOH A O   1 
HETATM 3758 O  O   . HOH G 6 .   ? -15.730 4.798   -23.691 1.00 13.69 ?  1036 HOH A O   1 
HETATM 3759 O  O   . HOH G 6 .   ? -30.165 11.082  11.358  1.00 21.91 ?  1037 HOH A O   1 
HETATM 3760 O  O   . HOH G 6 .   ? -17.527 -15.671 -1.048  1.00 42.04 ?  1038 HOH A O   1 
HETATM 3761 O  O   . HOH G 6 .   ? -0.882  -5.694  -6.666  1.00 31.53 ?  1039 HOH A O   1 
HETATM 3762 O  O   . HOH G 6 .   ? 3.642   -7.874  11.130  1.00 26.61 ?  1040 HOH A O   1 
HETATM 3763 O  O   . HOH G 6 .   ? -29.815 10.315  13.965  1.00 27.07 ?  1041 HOH A O   1 
HETATM 3764 O  O   . HOH G 6 .   ? -3.506  -9.949  0.195   1.00 23.45 ?  1042 HOH A O   1 
HETATM 3765 O  O   . HOH G 6 .   ? -23.661 -2.557  24.688  1.00 28.83 ?  1043 HOH A O   1 
HETATM 3766 O  O   . HOH G 6 .   ? -1.854  -6.438  -0.862  1.00 28.10 ?  1044 HOH A O   1 
HETATM 3767 O  O   . HOH G 6 .   ? -9.244  18.482  -6.928  1.00 30.53 ?  1045 HOH A O   1 
HETATM 3768 O  O   . HOH G 6 .   ? -36.323 0.652   -17.060 1.00 27.51 ?  1046 HOH A O   1 
HETATM 3769 O  O   . HOH G 6 .   ? -31.284 -0.030  -20.309 1.00 29.36 ?  1047 HOH A O   1 
HETATM 3770 O  O   . HOH G 6 .   ? -39.803 -10.015 5.679   1.00 29.73 ?  1048 HOH A O   1 
HETATM 3771 O  O   . HOH G 6 .   ? -37.372 3.501   7.612   1.00 26.91 ?  1049 HOH A O   1 
HETATM 3772 O  O   . HOH G 6 .   ? -4.567  9.221   -11.021 1.00 34.45 ?  1050 HOH A O   1 
HETATM 3773 O  O   . HOH G 6 .   ? -0.202  7.658   4.346   1.00 30.23 ?  1051 HOH A O   1 
HETATM 3774 O  O   . HOH G 6 .   ? -5.957  -9.273  -8.430  1.00 23.69 ?  1052 HOH A O   1 
HETATM 3775 O  O   . HOH G 6 .   ? -17.572 11.341  26.257  1.00 33.16 ?  1053 HOH A O   1 
HETATM 3776 O  O   . HOH G 6 .   ? -16.235 -16.690 33.718  1.00 25.81 ?  1054 HOH A O   1 
HETATM 3777 O  O   . HOH G 6 .   ? -17.256 27.788  12.802  1.00 27.30 ?  1055 HOH A O   1 
HETATM 3778 O  O   . HOH G 6 .   ? -5.914  0.844   -17.022 1.00 34.54 ?  1056 HOH A O   1 
HETATM 3779 O  O   . HOH G 6 .   ? -4.753  -7.533  -4.601  1.00 16.53 ?  1057 HOH A O   1 
HETATM 3780 O  O   . HOH G 6 .   ? -13.995 -29.576 0.537   1.00 14.94 ?  1058 HOH A O   1 
HETATM 3781 O  O   . HOH G 6 .   ? -0.618  -24.851 23.739  1.00 34.71 ?  1059 HOH A O   1 
HETATM 3782 O  O   . HOH G 6 .   ? 2.703   -9.161  7.382   1.00 24.23 ?  1060 HOH A O   1 
HETATM 3783 O  O   . HOH G 6 .   ? -38.346 -1.228  9.509   1.00 26.23 ?  1061 HOH A O   1 
HETATM 3784 O  O   . HOH G 6 .   ? -19.933 -16.299 34.110  1.00 33.08 ?  1062 HOH A O   1 
HETATM 3785 O  O   . HOH G 6 .   ? -17.156 -33.483 28.063  1.00 33.16 ?  1063 HOH A O   1 
HETATM 3786 O  O   . HOH G 6 .   ? -33.806 8.207   10.730  1.00 37.31 ?  1064 HOH A O   1 
HETATM 3787 O  O   . HOH G 6 .   ? -32.234 11.435  16.928  1.00 32.53 ?  1065 HOH A O   1 
HETATM 3788 O  O   . HOH G 6 .   ? -16.193 -19.227 -1.060  1.00 43.40 ?  1066 HOH A O   1 
HETATM 3789 O  O   . HOH G 6 .   ? -5.373  -11.860 -0.571  1.00 17.33 ?  1067 HOH A O   1 
HETATM 3790 O  O   . HOH G 6 .   ? -0.732  1.560   -3.939  1.00 25.12 ?  1068 HOH A O   1 
HETATM 3791 O  O   . HOH G 6 .   ? -34.414 2.575   -18.155 1.00 17.79 ?  1069 HOH A O   1 
HETATM 3792 O  O   . HOH G 6 .   ? -38.526 0.897   -15.716 1.00 30.95 ?  1070 HOH A O   1 
HETATM 3793 O  O   . HOH G 6 .   ? -26.497 21.017  -7.736  1.00 24.34 ?  1071 HOH A O   1 
HETATM 3794 O  O   . HOH G 6 .   ? -31.530 20.800  15.044  1.00 39.23 ?  1072 HOH A O   1 
HETATM 3795 O  O   . HOH G 6 .   ? -35.533 7.312   -16.749 1.00 20.45 ?  1073 HOH A O   1 
HETATM 3796 O  O   . HOH G 6 .   ? -32.806 8.397   -23.049 1.00 33.94 ?  1074 HOH A O   1 
HETATM 3797 O  O   . HOH G 6 .   ? -30.245 -21.117 19.469  1.00 32.82 ?  1075 HOH A O   1 
HETATM 3798 O  O   . HOH G 6 .   ? -26.429 21.031  6.786   1.00 26.57 ?  1076 HOH A O   1 
HETATM 3799 O  O   . HOH G 6 .   ? -4.246  -2.643  -14.530 1.00 33.20 ?  1077 HOH A O   1 
HETATM 3800 O  O   . HOH G 6 .   ? -0.726  10.266  9.943   1.00 25.01 ?  1078 HOH A O   1 
HETATM 3801 O  O   . HOH G 6 .   ? -1.095  3.107   4.916   1.00 22.99 ?  1079 HOH A O   1 
HETATM 3802 O  O   . HOH G 6 .   ? -13.221 -14.746 -2.366  1.00 30.53 ?  1080 HOH A O   1 
HETATM 3803 O  O   . HOH G 6 .   ? 0.158   -0.430  2.382   1.00 32.36 ?  1081 HOH A O   1 
HETATM 3804 O  O   . HOH G 6 .   ? -39.151 5.304   1.622   1.00 32.09 ?  1082 HOH A O   1 
HETATM 3805 O  O   . HOH G 6 .   ? -25.510 19.761  10.928  1.00 25.19 ?  1083 HOH A O   1 
HETATM 3806 O  O   . HOH G 6 .   ? -38.883 -6.841  3.086   1.00 29.49 ?  1084 HOH A O   1 
HETATM 3807 O  O   . HOH G 6 .   ? -6.134  -0.665  6.819   1.00 16.16 ?  1085 HOH A O   1 
HETATM 3808 O  O   . HOH G 6 .   ? -1.588  3.130   -8.099  1.00 30.07 ?  1086 HOH A O   1 
HETATM 3809 O  O   . HOH G 6 .   ? -18.069 -13.889 -3.980  1.00 26.85 ?  1087 HOH A O   1 
HETATM 3810 O  O   . HOH G 6 .   ? -5.028  -7.010  -12.575 1.00 30.14 ?  1088 HOH A O   1 
HETATM 3811 O  O   . HOH G 6 .   ? -30.092 0.540   -23.108 1.00 29.57 ?  1089 HOH A O   1 
HETATM 3812 O  O   . HOH G 6 .   ? 6.735   1.732   16.238  1.00 34.60 ?  1090 HOH A O   1 
HETATM 3813 O  O   . HOH G 6 .   ? -31.511 -2.259  -19.923 1.00 31.66 ?  1091 HOH A O   1 
HETATM 3814 O  O   . HOH G 6 .   ? -29.727 -20.775 1.425   1.00 29.75 ?  1092 HOH A O   1 
HETATM 3815 O  O   . HOH G 6 .   ? -27.441 -20.465 5.152   1.00 33.60 ?  1093 HOH A O   1 
HETATM 3816 O  O   . HOH G 6 .   ? 3.877   -10.626 10.506  1.00 29.93 ?  1094 HOH A O   1 
HETATM 3817 O  O   . HOH G 6 .   ? -20.644 -19.474 -0.471  1.00 31.43 ?  1095 HOH A O   1 
HETATM 3818 O  O   . HOH G 6 .   ? -15.637 24.525  -3.968  1.00 27.72 ?  1096 HOH A O   1 
HETATM 3819 O  O   . HOH G 6 .   ? -4.525  1.853   -12.049 1.00 30.01 ?  1097 HOH A O   1 
HETATM 3820 O  O   . HOH G 6 .   ? -36.976 7.619   5.056   1.00 32.64 ?  1098 HOH A O   1 
HETATM 3821 O  O   . HOH G 6 .   ? -0.683  3.892   2.219   1.00 25.49 ?  1099 HOH A O   1 
HETATM 3822 O  O   . HOH G 6 .   ? -35.795 -1.956  -17.655 1.00 19.25 ?  1100 HOH A O   1 
HETATM 3823 O  O   . HOH G 6 .   ? 7.488   -13.347 13.896  1.00 43.31 ?  1101 HOH A O   1 
HETATM 3824 O  O   . HOH G 6 .   ? -17.162 -26.147 0.725   1.00 29.18 ?  1102 HOH A O   1 
HETATM 3825 O  O   . HOH G 6 .   ? -15.221 -19.308 34.572  1.00 28.38 ?  1103 HOH A O   1 
HETATM 3826 O  O   . HOH G 6 .   ? 1.123   8.481   13.490  1.00 27.42 ?  1104 HOH A O   1 
HETATM 3827 O  O   . HOH G 6 .   ? -29.421 3.342   -22.918 1.00 24.96 ?  1105 HOH A O   1 
HETATM 3828 O  O   . HOH G 6 .   ? -36.707 -17.112 8.132   1.00 33.01 ?  1106 HOH A O   1 
HETATM 3829 O  O   . HOH G 6 .   ? -33.561 2.896   10.481  1.00 22.52 ?  1107 HOH A O   1 
HETATM 3830 O  O   . HOH G 6 .   ? -31.724 -4.179  -18.256 1.00 21.95 ?  1108 HOH A O   1 
HETATM 3831 O  O   . HOH G 6 .   ? -6.398  8.290   -14.938 1.00 30.77 ?  1109 HOH A O   1 
HETATM 3832 O  O   . HOH G 6 .   ? -25.961 -11.321 -15.640 1.00 27.83 ?  1110 HOH A O   1 
HETATM 3833 O  O   . HOH G 6 .   ? -10.451 -17.750 -5.786  1.00 30.12 ?  1111 HOH A O   1 
HETATM 3834 O  O   . HOH G 6 .   ? -0.263  1.602   0.351   1.00 25.71 ?  1112 HOH A O   1 
HETATM 3835 O  O   . HOH G 6 .   ? -19.548 -4.445  25.236  1.00 23.07 ?  1113 HOH A O   1 
HETATM 3836 O  O   . HOH G 6 .   ? 7.792   -15.947 14.677  1.00 34.40 ?  1114 HOH A O   1 
HETATM 3837 O  O   . HOH G 6 .   ? 2.952   -21.318 15.609  1.00 42.61 ?  1115 HOH A O   1 
HETATM 3838 O  O   . HOH G 6 .   ? -15.255 8.568   27.868  1.00 26.37 ?  1116 HOH A O   1 
HETATM 3839 O  O   . HOH G 6 .   ? -27.366 -1.938  23.438  1.00 30.12 ?  1117 HOH A O   1 
HETATM 3840 O  O   . HOH G 6 .   ? -0.979  -26.463 19.429  1.00 40.60 ?  1118 HOH A O   1 
HETATM 3841 O  O   . HOH G 6 .   ? -37.816 -11.119 2.106   1.00 20.56 ?  1119 HOH A O   1 
HETATM 3842 O  O   . HOH G 6 .   ? -4.717  -17.877 -2.813  1.00 31.14 ?  1120 HOH A O   1 
HETATM 3843 O  O   . HOH G 6 .   ? 0.809   1.870   -8.533  1.00 32.76 ?  1121 HOH A O   1 
HETATM 3844 O  O   . HOH G 6 .   ? -3.425  -9.940  -4.447  1.00 34.57 ?  1122 HOH A O   1 
HETATM 3845 O  O   . HOH G 6 .   ? -31.371 0.855   21.864  1.00 32.45 ?  1123 HOH A O   1 
HETATM 3846 O  O   . HOH G 6 .   ? -41.083 -8.404  7.303   1.00 30.47 ?  1124 HOH A O   1 
HETATM 3847 O  O   . HOH G 6 .   ? 3.084   1.440   4.229   1.00 36.36 ?  1125 HOH A O   1 
HETATM 3848 O  O   . HOH G 6 .   ? -22.155 -9.958  -9.891  1.00 25.44 ?  1126 HOH A O   1 
HETATM 3849 O  O   . HOH G 6 .   ? -35.374 5.315   -18.600 1.00 26.52 ?  1127 HOH A O   1 
HETATM 3850 O  O   . HOH G 6 .   ? -0.381  -27.603 17.088  1.00 40.42 ?  1128 HOH A O   1 
# 
