data_9EET
# 
_entry.id   9EET 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EET         pdb_00009eet 10.2210/pdb9eet/pdb 
WWPDB D_1000287643 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EET 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'omicron variant of nsp5 in complex with GC376' 
_pdbx_database_related.db_id          9EEI 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              ssarafi@emory.edu 
_pdbx_contact_author.name_first         Stefan 
_pdbx_contact_author.name_last          Sarafianos 
_pdbx_contact_author.name_mi            G 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5840-154X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Neilsen, G.'      1 0000-0001-9344-1160 
'Kirby, K.A.'      2 0000-0003-2468-4796 
'Sarafianos, S.G.' 3 0000-0002-5840-154X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci Adv' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2375-2548 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            11 
_citation.language                  ? 
_citation.page_first                eadv8875 
_citation.page_last                 eadv8875 
_citation.title                     'Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/sciadv.adv8875 
_citation.pdbx_database_id_PubMed   40479048 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Neilsen, G.'            1  0000-0001-9344-1160 
primary 'Lan, S.'                2  0009-0002-4101-9894 
primary 'Slack, R.L.'            3  0000-0002-5928-6205 
primary 'Lorson, Z.C.'           4  0009-0002-1404-9086 
primary 'Emanuelli Castaner, A.' 5  ?                   
primary 'Lee, R.'                6  0000-0002-5190-614X 
primary 'Edwards, K.G.'          7  ?                   
primary 'Zhang, H.'              8  ?                   
primary 'Lee, J.'                9  0000-0003-0472-827X 
primary 'Cantara, W.A.'          10 ?                   
primary 'Cilento, M.E.'          11 ?                   
primary 'Zhang, H.'              12 ?                   
primary 'De, R.'                 13 ?                   
primary 'Amblard, F.'            14 ?                   
primary 'Tedbury, P.R.'          15 0000-0001-8151-4967 
primary 'Kirby, K.A.'            16 0000-0003-2468-4796 
primary 'Schinazi, R.F.'         17 0000-0002-6688-3614 
primary 'Sarafianos, S.G.'       18 0000-0002-5840-154X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33795.562 
1  3.4.22.69 E166V 'UNP residues 3264-3569' ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1  ?         ?     ?                        ? 
3 water       nat water                                                                                                  18.015    
73 ?         ?     ?                        ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 VAL n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              WA1 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              RIL 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 GLN 306 306 306 GLN GLN A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1  401 401 UED K36 A . 
C 3 HOH 1  501 501 HOH HOH A . 
C 3 HOH 2  502 502 HOH HOH A . 
C 3 HOH 3  503 503 HOH HOH A . 
C 3 HOH 4  504 504 HOH HOH A . 
C 3 HOH 5  505 505 HOH HOH A . 
C 3 HOH 6  506 506 HOH HOH A . 
C 3 HOH 7  507 507 HOH HOH A . 
C 3 HOH 8  508 508 HOH HOH A . 
C 3 HOH 9  509 509 HOH HOH A . 
C 3 HOH 10 510 510 HOH HOH A . 
C 3 HOH 11 511 511 HOH HOH A . 
C 3 HOH 12 512 512 HOH HOH A . 
C 3 HOH 13 513 513 HOH HOH A . 
C 3 HOH 14 514 514 HOH HOH A . 
C 3 HOH 15 515 515 HOH HOH A . 
C 3 HOH 16 516 516 HOH HOH A . 
C 3 HOH 17 517 517 HOH HOH A . 
C 3 HOH 18 518 518 HOH HOH A . 
C 3 HOH 19 519 519 HOH HOH A . 
C 3 HOH 20 520 520 HOH HOH A . 
C 3 HOH 21 521 521 HOH HOH A . 
C 3 HOH 22 522 522 HOH HOH A . 
C 3 HOH 23 523 523 HOH HOH A . 
C 3 HOH 24 524 524 HOH HOH A . 
C 3 HOH 25 525 525 HOH HOH A . 
C 3 HOH 26 526 526 HOH HOH A . 
C 3 HOH 27 527 527 HOH HOH A . 
C 3 HOH 28 528 528 HOH HOH A . 
C 3 HOH 29 529 529 HOH HOH A . 
C 3 HOH 30 530 530 HOH HOH A . 
C 3 HOH 31 531 531 HOH HOH A . 
C 3 HOH 32 532 532 HOH HOH A . 
C 3 HOH 33 533 533 HOH HOH A . 
C 3 HOH 34 534 534 HOH HOH A . 
C 3 HOH 35 535 535 HOH HOH A . 
C 3 HOH 36 536 536 HOH HOH A . 
C 3 HOH 37 537 537 HOH HOH A . 
C 3 HOH 38 538 538 HOH HOH A . 
C 3 HOH 39 539 539 HOH HOH A . 
C 3 HOH 40 540 540 HOH HOH A . 
C 3 HOH 41 541 541 HOH HOH A . 
C 3 HOH 42 542 542 HOH HOH A . 
C 3 HOH 43 543 543 HOH HOH A . 
C 3 HOH 44 544 544 HOH HOH A . 
C 3 HOH 45 545 545 HOH HOH A . 
C 3 HOH 46 546 546 HOH HOH A . 
C 3 HOH 47 547 547 HOH HOH A . 
C 3 HOH 48 548 548 HOH HOH A . 
C 3 HOH 49 549 549 HOH HOH A . 
C 3 HOH 50 550 550 HOH HOH A . 
C 3 HOH 51 551 551 HOH HOH A . 
C 3 HOH 52 552 552 HOH HOH A . 
C 3 HOH 53 553 553 HOH HOH A . 
C 3 HOH 54 554 554 HOH HOH A . 
C 3 HOH 55 555 555 HOH HOH A . 
C 3 HOH 56 556 556 HOH HOH A . 
C 3 HOH 57 557 557 HOH HOH A . 
C 3 HOH 58 558 558 HOH HOH A . 
C 3 HOH 59 559 559 HOH HOH A . 
C 3 HOH 60 560 560 HOH HOH A . 
C 3 HOH 61 561 561 HOH HOH A . 
C 3 HOH 62 562 562 HOH HOH A . 
C 3 HOH 63 563 563 HOH HOH A . 
C 3 HOH 64 564 564 HOH HOH A . 
C 3 HOH 65 565 565 HOH HOH A . 
C 3 HOH 66 566 566 HOH HOH A . 
C 3 HOH 67 567 567 HOH HOH A . 
C 3 HOH 68 568 568 HOH HOH A . 
C 3 HOH 69 569 569 HOH HOH A . 
C 3 HOH 70 570 570 HOH HOH A . 
C 3 HOH 71 571 571 HOH HOH A . 
C 3 HOH 72 572 572 HOH HOH A . 
C 3 HOH 73 573 573 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.840 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EET 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.097 
_cell.length_a_esd                 ? 
_cell.length_b                     53.533 
_cell.length_b_esd                 ? 
_cell.length_c                     113.680 
_cell.length_c_esd                 ? 
_cell.volume                       269546.601 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EET 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EET 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.99 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.3 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG3350, ammonium formate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Si(111) DCM' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979338 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979338 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          40.14 
_reflns.entry_id                                       9EET 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.39 
_reflns.d_resolution_low                               34.13 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10643 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.99 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.123 
_reflns.pdbx_Rpim_I_all                                0.065 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       37006 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.104 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.39 
_reflns_shell.d_res_low                                     2.48 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           3654 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1086 
_reflns_shell.percent_possible_obs                          98.2 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.4 
_reflns_shell.pdbx_chi_squared                              0.97 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.6 
_reflns_shell.pdbx_Rrim_I_all                               0.847 
_reflns_shell.pdbx_Rpim_I_all                               0.453 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.614 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.713 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               41.28 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EET 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.39 
_refine.ls_d_res_low                             34.13 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10639 
_refine.ls_number_reflns_R_free                  558 
_refine.ls_number_reflns_R_work                  10081 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.65 
_refine.ls_percent_reflns_R_free                 5.24 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1949 
_refine.ls_R_factor_R_free                       0.2288 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1932 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.1893 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2920 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.39 
_refine_hist.d_res_low                        34.13 
_refine_hist.number_atoms_solvent             73 
_refine_hist.number_atoms_total               2467 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2365 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0044  ? 2493 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7000  ? 3395 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0483  ? 381  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0053  ? 442  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.7759 ? 895  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.39 2.63  . . 152 2467 99.09 . . . . 0.2724 . . . . . . . . . . . 0.3119 
'X-RAY DIFFRACTION' 2.63 3.01  . . 140 2512 99.81 . . . . 0.2340 . . . . . . . . . . . 0.2843 
'X-RAY DIFFRACTION' 3.01 3.79  . . 140 2511 99.92 . . . . 0.1927 . . . . . . . . . . . 0.2324 
'X-RAY DIFFRACTION' 3.79 34.13 . . 126 2591 99.82 . . . . 0.1621 . . . . . . . . . . . 0.1808 
# 
_struct.entry_id                     9EET 
_struct.title                        
'Crystal structure of the SARS-CoV-2 nsp5 main protease (Mpro) E166V mutant in complex with inhibitor GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EET 
_struct_keywords.text            'viral protein, NSP5, SARS-COV-2, GC376, drug resistance, HYDROLASE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   HYDROLASE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EET 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9EET 
_struct_ref_seq_dif.mon_id                       VAL 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      166 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    GLU 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3429 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            166 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3150  ? 
1 MORE         -18   ? 
1 'SSA (A^2)'  25000 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'light scattering' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_655 -x+1,y,-z -1.0000000000 0.0000000000 0.0000000000 45.0970000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? GLY A 215 ? ILE A 200 GLY A 215 1 ? 16 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.767 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O GLN A 69  ? O GLN A 69  N GLN A 19  ? N GLN A 19  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O CYS A 156 ? O CYS A 156 N ASP A 153 ? N ASP A 153 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9EET 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 53.27   -130.43 
2 1 ASN A 51  ? ? -153.81 75.67   
3 1 ASN A 84  ? ? 58.00   -120.40 
4 1 TYR A 154 ? ? 54.92   -88.14  
5 1 PRO A 184 ? ? -88.24  37.25   
6 1 ASN A 221 ? ? -103.93 -166.02 
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R01 AI167356' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7TGR 
_pdbx_initial_refinement_model.details          'ligand and solvent removed for MR' 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9EET 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022174 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004246 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018680 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008956 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? 6.76000  -21.66500 5.52400   1.000 51.55594 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? 7.43200  -20.55000 6.18400   1.000 50.50821 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? 8.92200  -20.52300 5.83600   1.000 51.45171 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? 9.62300  -21.52400 5.99500   1.000 45.03609 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? 7.24200  -20.62900 7.70400   1.000 47.88693 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? 7.71900  -21.85400 8.23300   1.000 44.76296 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? 9.39000  -19.37900 5.34900   1.000 52.95851 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? 10.79200 -19.17400 5.00400   1.000 46.07174 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? 11.11700 -19.60500 3.58700   1.000 48.17158 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? 10.48000 -20.48300 3.00600   1.000 50.60566 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? 12.14000 -18.97000 3.01500   1.000 45.65367 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? 12.60200 -19.29100 1.66600   1.000 44.24574 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? 14.12000 -19.38700 1.67500   1.000 42.23001 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? 14.80100 -18.42000 2.02800   1.000 44.32969 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? 12.13200 -18.24800 0.64400   1.000 41.09697 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? 12.00900 -18.78500 -0.75600  1.000 42.18339 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? 10.98800 -19.66500 -1.08300  1.000 41.16873 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? 12.90700 -18.40900 -1.74400  1.000 39.09028 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? 10.86300 -20.16100 -2.36700  1.000 44.43631 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? 12.78600 -18.90000 -3.03200  1.000 38.39892 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? 11.76200 -19.77800 -3.34300  1.000 43.38171 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? 14.64300 -20.55200 1.28600   1.000 39.79746 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? 16.06900 -20.84200 1.31500   1.000 35.06650 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? 16.51600 -21.37200 -0.04100  1.000 41.69572 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? 15.72700 -21.95700 -0.78800  1.000 37.33785 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? 16.41300 -21.87900 2.39700   1.000 33.50348 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? 16.14100 -21.42900 3.82100   1.000 45.39359 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? 17.04200 -20.26600 4.20400   1.000 45.09142 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? 18.41500 -20.53600 3.80800   1.000 42.96257 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? 19.25900 -21.28500 4.50300   1.000 46.42532 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? 18.92600 -21.78800 5.68200   1.000 42.79936 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? 20.46100 -21.55000 3.99600   1.000 41.35601 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? 17.79500 -21.16800 -0.35000  1.000 39.23574 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? 18.41200 -21.77700 -1.52800  1.000 42.33017 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? 18.79500 -23.20000 -1.14600  1.000 38.02888 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? 19.89000 -23.46400 -0.65000  1.000 41.38029 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? 19.62300 -20.97400 -1.98900  1.000 34.19977 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? 20.01100 -21.23200 -3.43100  1.000 42.28040 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? 21.03700 -20.22400 -3.91700  1.000 45.80350 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? 20.48800 -18.81200 -3.85400  1.000 46.76890 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? 21.45100 -17.88700 -3.20200  1.000 46.47012 ? 5   LYS A NZ  1 
ATOM   42   N N   A MET A 1 6   ? 17.87200 -24.13100 -1.36900  0.131 37.14493 ? 6   MET A N   1 
ATOM   43   N N   B MET A 1 6   ? 17.87900 -24.12800 -1.35700  0.869 37.08727 ? 6   MET A N   1 
ATOM   44   C CA  A MET A 1 6   ? 18.06400 -25.52100 -0.98500  0.131 37.98514 ? 6   MET A CA  1 
ATOM   45   C CA  B MET A 1 6   ? 18.12700 -25.50700 -0.98200  0.869 38.07630 ? 6   MET A CA  1 
ATOM   46   C C   A MET A 1 6   ? 18.41100 -26.36700 -2.20500  0.131 37.52613 ? 6   MET A C   1 
ATOM   47   C C   B MET A 1 6   ? 18.47300 -26.33300 -2.21200  0.869 37.70388 ? 6   MET A C   1 
ATOM   48   O O   A MET A 1 6   ? 17.97300 -26.08600 -3.32400  0.131 39.18828 ? 6   MET A O   1 
ATOM   49   O O   B MET A 1 6   ? 18.08200 -26.02000 -3.33700  0.869 39.08255 ? 6   MET A O   1 
ATOM   50   C CB  A MET A 1 6   ? 16.81400 -26.07100 -0.29400  0.131 37.82677 ? 6   MET A CB  1 
ATOM   51   C CB  B MET A 1 6   ? 16.91800 -26.10200 -0.25900  0.869 37.80773 ? 6   MET A CB  1 
ATOM   52   C CG  A MET A 1 6   ? 15.53600 -25.90000 -1.08900  0.131 39.23574 ? 6   MET A CG  1 
ATOM   53   C CG  B MET A 1 6   ? 15.70700 -26.35900 -1.13000  0.869 39.14878 ? 6   MET A CG  1 
ATOM   54   S SD  A MET A 1 6   ? 14.08100 -26.36200 -0.13300  0.131 41.80618 ? 6   MET A SD  1 
ATOM   55   S SD  B MET A 1 6   ? 14.43400 -27.18400 -0.15600  0.869 47.64454 ? 6   MET A SD  1 
ATOM   56   C CE  A MET A 1 6   ? 13.05800 -27.07500 -1.41800  0.131 43.61397 ? 6   MET A CE  1 
ATOM   57   C CE  B MET A 1 6   ? 14.19600 -25.98900 1.15200   0.869 32.88519 ? 6   MET A CE  1 
ATOM   58   N N   . ALA A 1 7   ? 19.22200 -27.39800 -1.97800  1.000 37.03662 ? 7   ALA A N   1 
ATOM   59   C CA  . ALA A 1 7   ? 19.64600 -28.31000 -3.02500  1.000 37.32527 ? 7   ALA A CA  1 
ATOM   60   C C   . ALA A 1 7   ? 18.89400 -29.63000 -2.90700  1.000 32.71247 ? 7   ALA A C   1 
ATOM   61   O O   . ALA A 1 7   ? 18.32100 -29.94700 -1.86300  1.000 33.48640 ? 7   ALA A O   1 
ATOM   62   C CB  . ALA A 1 7   ? 21.15600 -28.54600 -2.95000  1.000 29.25766 ? 7   ALA A CB  1 
ATOM   63   N N   . PHE A 1 8   ? 18.89900 -30.39400 -4.00300  1.000 39.08892 ? 8   PHE A N   1 
ATOM   64   C CA  . PHE A 1 8   ? 18.32800 -31.73400 -4.00500  1.000 36.34668 ? 8   PHE A CA  1 
ATOM   65   C C   . PHE A 1 8   ? 19.06000 -32.63500 -3.01200  1.000 36.85688 ? 8   PHE A C   1 
ATOM   66   O O   . PHE A 1 8   ? 20.24100 -32.42600 -2.71600  1.000 32.49831 ? 8   PHE A O   1 
ATOM   67   C CB  . PHE A 1 8   ? 18.40900 -32.37400 -5.39500  1.000 35.94447 ? 8   PHE A CB  1 
ATOM   68   C CG  . PHE A 1 8   ? 17.54100 -31.72000 -6.43200  1.000 40.49376 ? 8   PHE A CG  1 
ATOM   69   C CD1 . PHE A 1 8   ? 16.21700 -32.08000 -6.58500  1.000 42.53368 ? 8   PHE A CD1 1 
ATOM   70   C CD2 . PHE A 1 8   ? 18.07100 -30.75300 -7.26800  1.000 41.78559 ? 8   PHE A CD2 1 
ATOM   71   C CE1 . PHE A 1 8   ? 15.44300 -31.47000 -7.55300  1.000 42.35204 ? 8   PHE A CE1 1 
ATOM   72   C CE2 . PHE A 1 8   ? 17.31200 -30.13700 -8.23100  1.000 39.25172 ? 8   PHE A CE2 1 
ATOM   73   C CZ  . PHE A 1 8   ? 16.01400 -30.49800 -8.38400  1.000 43.34002 ? 8   PHE A CZ  1 
ATOM   74   N N   . PRO A 1 9   ? 18.38000 -33.65500 -2.49800  1.000 37.34569 ? 9   PRO A N   1 
ATOM   75   C CA  . PRO A 1 9   ? 19.07400 -34.71700 -1.75800  1.000 36.77561 ? 9   PRO A CA  1 
ATOM   76   C C   . PRO A 1 9   ? 20.07500 -35.42700 -2.65800  1.000 38.44703 ? 9   PRO A C   1 
ATOM   77   O O   . PRO A 1 9   ? 19.71400 -36.00300 -3.68900  1.000 42.23690 ? 9   PRO A O   1 
ATOM   78   C CB  . PRO A 1 9   ? 17.93200 -35.64400 -1.32800  1.000 38.55787 ? 9   PRO A CB  1 
ATOM   79   C CG  . PRO A 1 9   ? 16.69400 -34.78800 -1.40200  1.000 41.90223 ? 9   PRO A CG  1 
ATOM   80   C CD  . PRO A 1 9   ? 16.92600 -33.87400 -2.55300  1.000 40.31206 ? 9   PRO A CD  1 
ATOM   81   N N   . SER A 1 10  ? 21.34400 -35.39300 -2.25100  1.000 33.76811 ? 10  SER A N   1 
ATOM   82   C CA  . SER A 1 10  ? 22.45100 -35.88800 -3.05800  1.000 34.37063 ? 10  SER A CA  1 
ATOM   83   C C   . SER A 1 10  ? 22.74500 -37.36700 -2.83900  1.000 33.90920 ? 10  SER A C   1 
ATOM   84   O O   . SER A 1 10  ? 23.76600 -37.85800 -3.32900  1.000 29.82506 ? 10  SER A O   1 
ATOM   85   C CB  . SER A 1 10  ? 23.71100 -35.06700 -2.77200  1.000 35.07903 ? 10  SER A CB  1 
ATOM   86   O OG  . SER A 1 10  ? 24.10800 -35.20600 -1.41800  1.000 33.24823 ? 10  SER A OG  1 
ATOM   87   N N   . GLY A 1 11  ? 21.87100 -38.08900 -2.13400  1.000 40.94370 ? 11  GLY A N   1 
ATOM   88   C CA  . GLY A 1 11  ? 22.16600 -39.47700 -1.80500  1.000 39.56775 ? 11  GLY A CA  1 
ATOM   89   C C   . GLY A 1 11  ? 22.30500 -40.36900 -3.02500  1.000 35.81523 ? 11  GLY A C   1 
ATOM   90   O O   . GLY A 1 11  ? 23.14800 -41.26800 -3.05400  1.000 41.46682 ? 11  GLY A O   1 
ATOM   91   N N   . LYS A 1 12  ? 21.47800 -40.14100 -4.04700  1.000 37.04360 ? 12  LYS A N   1 
ATOM   92   C CA  . LYS A 1 12  ? 21.56200 -40.95800 -5.25200  1.000 34.66925 ? 12  LYS A CA  1 
ATOM   93   C C   . LYS A 1 12  ? 22.82400 -40.67400 -6.05600  1.000 41.31247 ? 12  LYS A C   1 
ATOM   94   O O   . LYS A 1 12  ? 23.26400 -41.53900 -6.82100  1.000 44.15050 ? 12  LYS A O   1 
ATOM   95   C CB  . LYS A 1 12  ? 20.32300 -40.74100 -6.12300  1.000 35.10347 ? 12  LYS A CB  1 
ATOM   96   C CG  . LYS A 1 12  ? 19.03900 -41.31100 -5.53700  1.000 31.16020 ? 12  LYS A CG  1 
ATOM   97   C CD  . LYS A 1 12  ? 17.82500 -40.84800 -6.32500  1.000 40.75487 ? 12  LYS A CD  1 
ATOM   98   C CE  . LYS A 1 12  ? 16.55800 -41.54500 -5.86200  1.000 42.50916 ? 12  LYS A CE  1 
ATOM   99   N NZ  . LYS A 1 12  ? 16.60500 -43.00300 -6.15300  1.000 50.84675 ? 12  LYS A NZ  1 
ATOM   100  N N   . VAL A 1 13  ? 23.41200 -39.49000 -5.89800  1.000 33.24403 ? 13  VAL A N   1 
ATOM   101  C CA  . VAL A 1 13  ? 24.61800 -39.14100 -6.63600  1.000 30.28216 ? 13  VAL A CA  1 
ATOM   102  C C   . VAL A 1 13  ? 25.88500 -39.55500 -5.88700  1.000 35.05722 ? 13  VAL A C   1 
ATOM   103  O O   . VAL A 1 13  ? 26.88900 -39.89800 -6.52000  1.000 36.68602 ? 13  VAL A O   1 
ATOM   104  C CB  . VAL A 1 13  ? 24.62100 -37.63500 -6.94700  1.000 33.89576 ? 13  VAL A CB  1 
ATOM   105  C CG1 . VAL A 1 13  ? 25.80700 -37.26500 -7.82800  1.000 30.00666 ? 13  VAL A CG1 1 
ATOM   106  C CG2 . VAL A 1 13  ? 23.31600 -37.23500 -7.61300  1.000 31.14362 ? 13  VAL A CG2 1 
ATOM   107  N N   . GLU A 1 14  ? 25.85700 -39.53800 -4.55000  1.000 34.95552 ? 14  GLU A N   1 
ATOM   108  C CA  . GLU A 1 14  ? 27.01200 -39.98500 -3.77200  1.000 36.33383 ? 14  GLU A CA  1 
ATOM   109  C C   . GLU A 1 14  ? 27.42000 -41.40500 -4.14600  1.000 37.53112 ? 14  GLU A C   1 
ATOM   110  O O   . GLU A 1 14  ? 28.61400 -41.71800 -4.21900  1.000 34.89413 ? 14  GLU A O   1 
ATOM   111  C CB  . GLU A 1 14  ? 26.70500 -39.89800 -2.27600  1.000 34.01513 ? 14  GLU A CB  1 
ATOM   112  C CG  . GLU A 1 14  ? 26.44400 -38.49300 -1.77300  1.000 37.90733 ? 14  GLU A CG  1 
ATOM   113  C CD  . GLU A 1 14  ? 25.85700 -38.46800 -0.37400  1.000 36.46933 ? 14  GLU A CD  1 
ATOM   114  O OE1 . GLU A 1 14  ? 26.14400 -39.39000 0.41500   1.000 43.68914 ? 14  GLU A OE1 1 
ATOM   115  O OE2 . GLU A 1 14  ? 25.10000 -37.52600 -0.06700  1.000 35.62212 ? 14  GLU A OE2 1 
ATOM   116  N N   . GLY A 1 15  ? 26.44500 -42.27700 -4.39700  1.000 35.26329 ? 15  GLY A N   1 
ATOM   117  C CA  . GLY A 1 15  ? 26.75000 -43.64300 -4.77700  1.000 39.83684 ? 15  GLY A CA  1 
ATOM   118  C C   . GLY A 1 15  ? 27.38600 -43.81300 -6.14000  1.000 38.68812 ? 15  GLY A C   1 
ATOM   119  O O   . GLY A 1 15  ? 27.76900 -44.93500 -6.48500  1.000 38.27467 ? 15  GLY A O   1 
ATOM   120  N N   . CYS A 1 16  ? 27.51600 -42.73800 -6.91900  1.000 40.56789 ? 16  CYS A N   1 
ATOM   121  C CA  . CYS A 1 16  ? 28.08000 -42.80100 -8.26000  1.000 36.42877 ? 16  CYS A CA  1 
ATOM   122  C C   . CYS A 1 16  ? 29.44000 -42.13000 -8.37500  1.000 35.45926 ? 16  CYS A C   1 
ATOM   123  O O   . CYS A 1 16  ? 30.01700 -42.12000 -9.46800  1.000 38.44609 ? 16  CYS A O   1 
ATOM   124  C CB  . CYS A 1 16  ? 27.12100 -42.15900 -9.26800  1.000 39.02972 ? 16  CYS A CB  1 
ATOM   125  S SG  . CYS A 1 16  ? 25.42500 -42.75400 -9.19000  1.000 43.52937 ? 16  CYS A SG  1 
ATOM   126  N N   . MET A 1 17  ? 29.96400 -41.56300 -7.29300  1.000 33.66564 ? 17  MET A N   1 
ATOM   127  C CA  . MET A 1 17  ? 31.20900 -40.80900 -7.34400  1.000 32.96927 ? 17  MET A CA  1 
ATOM   128  C C   . MET A 1 17  ? 32.38900 -41.73600 -7.08000  1.000 38.85218 ? 17  MET A C   1 
ATOM   129  O O   . MET A 1 17  ? 32.45800 -42.37800 -6.02700  1.000 40.98300 ? 17  MET A O   1 
ATOM   130  C CB  . MET A 1 17  ? 31.18800 -39.66700 -6.33100  1.000 35.98574 ? 17  MET A CB  1 
ATOM   131  C CG  . MET A 1 17  ? 30.07700 -38.66500 -6.56800  1.000 36.02152 ? 17  MET A CG  1 
ATOM   132  S SD  . MET A 1 17  ? 30.02100 -38.11400 -8.28100  1.000 35.56551 ? 17  MET A SD  1 
ATOM   133  C CE  . MET A 1 17  ? 31.62700 -37.33800 -8.44600  1.000 32.27366 ? 17  MET A CE  1 
ATOM   134  N N   . VAL A 1 18  ? 33.31700 -41.79700 -8.03400  1.000 40.73715 ? 18  VAL A N   1 
ATOM   135  C CA  . VAL A 1 18  ? 34.52400 -42.60100 -7.91300  1.000 37.16011 ? 18  VAL A CA  1 
ATOM   136  C C   . VAL A 1 18  ? 35.73700 -41.69400 -8.09400  1.000 36.70508 ? 18  VAL A C   1 
ATOM   137  O O   . VAL A 1 18  ? 35.61900 -40.51200 -8.41400  1.000 37.41238 ? 18  VAL A O   1 
ATOM   138  C CB  . VAL A 1 18  ? 34.55900 -43.76300 -8.92200  1.000 39.21415 ? 18  VAL A CB  1 
ATOM   139  C CG1 . VAL A 1 18  ? 33.32500 -44.63000 -8.77100  1.000 42.94497 ? 18  VAL A CG1 1 
ATOM   140  C CG2 . VAL A 1 18  ? 34.67500 -43.23000 -10.34200 1.000 36.11596 ? 18  VAL A CG2 1 
ATOM   141  N N   . GLN A 1 19  ? 36.91300 -42.27300 -7.88100  1.000 40.06297 ? 19  GLN A N   1 
ATOM   142  C CA  . GLN A 1 19  ? 38.18100 -41.57200 -8.01100  1.000 38.39723 ? 19  GLN A CA  1 
ATOM   143  C C   . GLN A 1 19  ? 38.91600 -42.10700 -9.23200  1.000 41.36121 ? 19  GLN A C   1 
ATOM   144  O O   . GLN A 1 19  ? 38.99400 -43.32400 -9.42800  1.000 46.03200 ? 19  GLN A O   1 
ATOM   145  C CB  . GLN A 1 19  ? 39.02700 -41.75100 -6.74900  1.000 40.13754 ? 19  GLN A CB  1 
ATOM   146  C CG  . GLN A 1 19  ? 40.37400 -41.05500 -6.79700  1.000 47.43796 ? 19  GLN A CG  1 
ATOM   147  C CD  . GLN A 1 19  ? 41.26000 -41.42200 -5.62200  1.000 47.35441 ? 19  GLN A CD  1 
ATOM   148  O OE1 . GLN A 1 19  ? 41.46200 -42.60000 -5.32800  1.000 54.86405 ? 19  GLN A OE1 1 
ATOM   149  N NE2 . GLN A 1 19  ? 41.78800 -40.41300 -4.93900  1.000 47.29286 ? 19  GLN A NE2 1 
ATOM   150  N N   . VAL A 1 20  ? 39.44700 -41.20200 -10.05200 1.000 36.87019 ? 20  VAL A N   1 
ATOM   151  C CA  . VAL A 1 20  ? 40.13600 -41.56700 -11.28500 1.000 36.66780 ? 20  VAL A CA  1 
ATOM   152  C C   . VAL A 1 20  ? 41.48800 -40.87800 -11.30300 1.000 40.43520 ? 20  VAL A C   1 
ATOM   153  O O   . VAL A 1 20  ? 41.56700 -39.65000 -11.17200 1.000 37.35354 ? 20  VAL A O   1 
ATOM   154  C CB  . VAL A 1 20  ? 39.33000 -41.18800 -12.53700 1.000 39.16535 ? 20  VAL A CB  1 
ATOM   155  C CG1 . VAL A 1 20  ? 40.11200 -41.54500 -13.79300 1.000 40.77325 ? 20  VAL A CG1 1 
ATOM   156  C CG2 . VAL A 1 20  ? 37.98200 -41.88600 -12.52900 1.000 39.46414 ? 20  VAL A CG2 1 
ATOM   157  N N   . THR A 1 21  ? 42.54700 -41.66300 -11.46700 1.000 41.16818 ? 21  THR A N   1 
ATOM   158  C CA  . THR A 1 21  ? 43.88800 -41.13200 -11.63600 1.000 40.64776 ? 21  THR A CA  1 
ATOM   159  C C   . THR A 1 21  ? 44.48000 -41.65000 -12.93800 1.000 39.50134 ? 21  THR A C   1 
ATOM   160  O O   . THR A 1 21  ? 44.30200 -42.81900 -13.28900 1.000 43.18050 ? 21  THR A O   1 
ATOM   161  C CB  . THR A 1 21  ? 44.80000 -41.52100 -10.46700 1.000 46.29773 ? 21  THR A CB  1 
ATOM   162  O OG1 . THR A 1 21  ? 44.18500 -41.14900 -9.22900  1.000 40.84301 ? 21  THR A OG1 1 
ATOM   163  C CG2 . THR A 1 21  ? 46.13700 -40.82200 -10.58600 1.000 42.03730 ? 21  THR A CG2 1 
ATOM   164  N N   . CYS A 1 22  ? 45.16800 -40.76800 -13.65700 1.000 42.50947 ? 22  CYS A N   1 
ATOM   165  C CA  . CYS A 1 22  ? 45.95900 -41.12800 -14.82700 1.000 38.91073 ? 22  CYS A CA  1 
ATOM   166  C C   . CYS A 1 22  ? 47.29800 -40.42500 -14.67100 1.000 49.49880 ? 22  CYS A C   1 
ATOM   167  O O   . CYS A 1 22  ? 47.37400 -39.19500 -14.76400 1.000 48.18348 ? 22  CYS A O   1 
ATOM   168  C CB  . CYS A 1 22  ? 45.26200 -40.72400 -16.12700 1.000 39.93115 ? 22  CYS A CB  1 
ATOM   169  S SG  . CYS A 1 22  ? 46.06200 -41.35400 -17.62500 1.000 47.55911 ? 22  CYS A SG  1 
ATOM   170  N N   . GLY A 1 23  ? 48.34800 -41.20000 -14.41900 1.000 48.66941 ? 23  GLY A N   1 
ATOM   171  C CA  . GLY A 1 23  ? 49.62800 -40.61800 -14.07700 1.000 47.26235 ? 23  GLY A CA  1 
ATOM   172  C C   . GLY A 1 23  ? 49.60800 -40.00100 -12.69400 1.000 50.62513 ? 23  GLY A C   1 
ATOM   173  O O   . GLY A 1 23  ? 49.35000 -40.69200 -11.70300 1.000 48.59285 ? 23  GLY A O   1 
ATOM   174  N N   . THR A 1 24  ? 49.87100 -38.69600 -12.61300 1.000 57.36687 ? 24  THR A N   1 
ATOM   175  C CA  . THR A 1 24  ? 49.86900 -37.97900 -11.34500 1.000 56.65117 ? 24  THR A CA  1 
ATOM   176  C C   . THR A 1 24  ? 48.59700 -37.17300 -11.10900 1.000 55.34435 ? 24  THR A C   1 
ATOM   177  O O   . THR A 1 24  ? 48.39400 -36.68300 -9.99300  1.000 66.37491 ? 24  THR A O   1 
ATOM   178  C CB  . THR A 1 24  ? 51.08100 -37.04000 -11.26400 1.000 61.04452 ? 24  THR A CB  1 
ATOM   179  O OG1 . THR A 1 24  ? 50.99500 -36.05700 -12.30300 1.000 59.40862 ? 24  THR A OG1 1 
ATOM   180  C CG2 . THR A 1 24  ? 52.37600 -37.82200 -11.42200 1.000 62.96555 ? 24  THR A CG2 1 
ATOM   181  N N   . THR A 1 25  ? 47.74200 -37.02500 -12.11700 1.000 48.81899 ? 25  THR A N   1 
ATOM   182  C CA  . THR A 1 25  ? 46.52800 -36.22800 -11.99700 1.000 48.65132 ? 25  THR A CA  1 
ATOM   183  C C   . THR A 1 25  ? 45.38900 -37.08100 -11.45300 1.000 43.74799 ? 25  THR A C   1 
ATOM   184  O O   . THR A 1 25  ? 45.14400 -38.18400 -11.94800 1.000 44.35702 ? 25  THR A O   1 
ATOM   185  C CB  . THR A 1 25  ? 46.13700 -35.63900 -13.35300 1.000 45.94976 ? 25  THR A CB  1 
ATOM   186  O OG1 . THR A 1 25  ? 47.21100 -34.83400 -13.85600 1.000 54.51141 ? 25  THR A OG1 1 
ATOM   187  C CG2 . THR A 1 25  ? 44.88800 -34.78500 -13.22100 1.000 44.79752 ? 25  THR A CG2 1 
ATOM   188  N N   . THR A 1 26  ? 44.68900 -36.56300 -10.44600 1.000 46.68875 ? 26  THR A N   1 
ATOM   189  C CA  . THR A 1 26  ? 43.55800 -37.25600 -9.84100  1.000 41.37433 ? 26  THR A CA  1 
ATOM   190  C C   . THR A 1 26  ? 42.34200 -36.34400 -9.83900  1.000 37.02348 ? 26  THR A C   1 
ATOM   191  O O   . THR A 1 26  ? 42.42600 -35.19400 -9.39700  1.000 44.13811 ? 26  THR A O   1 
ATOM   192  C CB  . THR A 1 26  ? 43.87100 -37.70200 -8.41000  1.000 40.70588 ? 26  THR A CB  1 
ATOM   193  O OG1 . THR A 1 26  ? 44.93100 -38.66500 -8.42900  1.000 53.38381 ? 26  THR A OG1 1 
ATOM   194  C CG2 . THR A 1 26  ? 42.63900 -38.32400 -7.76300  1.000 39.83020 ? 26  THR A CG2 1 
ATOM   195  N N   . LEU A 1 27  ? 41.21600 -36.85900 -10.32500 1.000 36.08720 ? 27  LEU A N   1 
ATOM   196  C CA  . LEU A 1 27  ? 39.95700 -36.13200 -10.27600 1.000 36.70913 ? 27  LEU A CA  1 
ATOM   197  C C   . LEU A 1 27  ? 38.82200 -37.13200 -10.07700 1.000 38.32571 ? 27  LEU A C   1 
ATOM   198  O O   . LEU A 1 27  ? 39.04400 -38.34000 -9.94700  1.000 36.65998 ? 27  LEU A O   1 
ATOM   199  C CB  . LEU A 1 27  ? 39.77100 -35.27300 -11.53300 1.000 36.00426 ? 27  LEU A CB  1 
ATOM   200  C CG  . LEU A 1 27  ? 40.13000 -35.84800 -12.90300 1.000 34.18658 ? 27  LEU A CG  1 
ATOM   201  C CD1 . LEU A 1 27  ? 39.12900 -36.89900 -13.34800 1.000 35.29121 ? 27  LEU A CD1 1 
ATOM   202  C CD2 . LEU A 1 27  ? 40.21300 -34.72600 -13.92300 1.000 33.16959 ? 27  LEU A CD2 1 
ATOM   203  N N   . ASN A 1 28  ? 37.59700 -36.61800 -10.06000 1.000 34.43997 ? 28  ASN A N   1 
ATOM   204  C CA  . ASN A 1 28  ? 36.43000 -37.42900 -9.75400  1.000 32.49960 ? 28  ASN A CA  1 
ATOM   205  C C   . ASN A 1 28  ? 35.80300 -37.98800 -11.02700 1.000 33.95376 ? 28  ASN A C   1 
ATOM   206  O O   . ASN A 1 28  ? 35.96400 -37.44400 -12.12200 1.000 32.08585 ? 28  ASN A O   1 
ATOM   207  C CB  . ASN A 1 28  ? 35.40100 -36.60700 -8.98000  1.000 33.52507 ? 28  ASN A CB  1 
ATOM   208  C CG  . ASN A 1 28  ? 35.99400 -35.93900 -7.75600  1.000 40.16359 ? 28  ASN A CG  1 
ATOM   209  O OD1 . ASN A 1 28  ? 36.27200 -36.59700 -6.75300  1.000 40.06896 ? 28  ASN A OD1 1 
ATOM   210  N ND2 . ASN A 1 28  ? 36.19200 -34.62600 -7.83300  1.000 35.36483 ? 28  ASN A ND2 1 
ATOM   211  N N   . GLY A 1 29  ? 35.08100 -39.08800 -10.86600 1.000 28.06854 ? 29  GLY A N   1 
ATOM   212  C CA  . GLY A 1 29  ? 34.39700 -39.71700 -11.98100 1.000 30.82282 ? 29  GLY A CA  1 
ATOM   213  C C   . GLY A 1 29  ? 32.97800 -40.08500 -11.60600 1.000 35.68199 ? 29  GLY A C   1 
ATOM   214  O O   . GLY A 1 29  ? 32.64800 -40.26700 -10.43200 1.000 34.91307 ? 29  GLY A O   1 
ATOM   215  N N   . LEU A 1 30  ? 32.13100 -40.18900 -12.62700 1.000 27.70411 ? 30  LEU A N   1 
ATOM   216  C CA  . LEU A 1 30  ? 30.72900 -40.54900 -12.45600 1.000 29.37346 ? 30  LEU A CA  1 
ATOM   217  C C   . LEU A 1 30  ? 30.53300 -41.98300 -12.93000 1.000 33.55507 ? 30  LEU A C   1 
ATOM   218  O O   . LEU A 1 30  ? 30.71300 -42.28000 -14.11600 1.000 31.18712 ? 30  LEU A O   1 
ATOM   219  C CB  . LEU A 1 30  ? 29.81300 -39.59800 -13.22700 1.000 29.92472 ? 30  LEU A CB  1 
ATOM   220  C CG  . LEU A 1 30  ? 28.30800 -39.78200 -13.00300 1.000 30.37538 ? 30  LEU A CG  1 
ATOM   221  C CD1 . LEU A 1 30  ? 27.93200 -39.39600 -11.58300 1.000 31.44108 ? 30  LEU A CD1 1 
ATOM   222  C CD2 . LEU A 1 30  ? 27.49100 -38.98700 -14.01100 1.000 23.83735 ? 30  LEU A CD2 1 
ATOM   223  N N   . TRP A 1 31  ? 30.16700 -42.86500 -12.00800 1.000 35.09948 ? 31  TRP A N   1 
ATOM   224  C CA  . TRP A 1 31  ? 30.05500 -44.29200 -12.28000 1.000 36.42862 ? 31  TRP A CA  1 
ATOM   225  C C   . TRP A 1 31  ? 28.58100 -44.64300 -12.45500 1.000 36.50255 ? 31  TRP A C   1 
ATOM   226  O O   . TRP A 1 31  ? 27.82700 -44.70300 -11.47900 1.000 37.19700 ? 31  TRP A O   1 
ATOM   227  C CB  . TRP A 1 31  ? 30.69600 -45.10100 -11.15400 1.000 36.27099 ? 31  TRP A CB  1 
ATOM   228  C CG  . TRP A 1 31  ? 30.73100 -46.57600 -11.38900 1.000 39.67721 ? 31  TRP A CG  1 
ATOM   229  C CD1 . TRP A 1 31  ? 30.55400 -47.22800 -12.57600 1.000 42.63568 ? 31  TRP A CD1 1 
ATOM   230  C CD2 . TRP A 1 31  ? 30.94700 -47.59100 -10.40200 1.000 42.54042 ? 31  TRP A CD2 1 
ATOM   231  N NE1 . TRP A 1 31  ? 30.65000 -48.58700 -12.38800 1.000 43.56485 ? 31  TRP A NE1 1 
ATOM   232  C CE2 . TRP A 1 31  ? 30.89100 -48.83500 -11.06200 1.000 43.01232 ? 31  TRP A CE2 1 
ATOM   233  C CE3 . TRP A 1 31  ? 31.18100 -47.56900 -9.02400  1.000 43.50366 ? 31  TRP A CE3 1 
ATOM   234  C CZ2 . TRP A 1 31  ? 31.06300 -50.04200 -10.39200 1.000 42.83964 ? 31  TRP A CZ2 1 
ATOM   235  C CZ3 . TRP A 1 31  ? 31.35200 -48.76900 -8.36100  1.000 46.60649 ? 31  TRP A CZ3 1 
ATOM   236  C CH2 . TRP A 1 31  ? 31.29100 -49.98800 -9.04500  1.000 42.76153 ? 31  TRP A CH2 1 
ATOM   237  N N   . LEU A 1 32  ? 28.17700 -44.86500 -13.70200 1.000 32.42455 ? 32  LEU A N   1 
ATOM   238  C CA  . LEU A 1 32  ? 26.82100 -45.27000 -14.03800 1.000 33.89446 ? 32  LEU A CA  1 
ATOM   239  C C   . LEU A 1 32  ? 26.89900 -46.51800 -14.89900 1.000 41.82948 ? 32  LEU A C   1 
ATOM   240  O O   . LEU A 1 32  ? 27.65100 -46.54700 -15.88100 1.000 34.16543 ? 32  LEU A O   1 
ATOM   241  C CB  . LEU A 1 32  ? 26.07400 -44.15600 -14.77700 1.000 36.13005 ? 32  LEU A CB  1 
ATOM   242  C CG  . LEU A 1 32  ? 25.94400 -42.83200 -14.02500 1.000 34.24157 ? 32  LEU A CG  1 
ATOM   243  C CD1 . LEU A 1 32  ? 25.34100 -41.77300 -14.92500 1.000 35.39819 ? 32  LEU A CD1 1 
ATOM   244  C CD2 . LEU A 1 32  ? 25.11100 -43.01000 -12.77000 1.000 33.62933 ? 32  LEU A CD2 1 
ATOM   245  N N   . ASP A 1 33  ? 26.12900 -47.54000 -14.52800 1.000 38.08001 ? 33  ASP A N   1 
ATOM   246  C CA  . ASP A 1 33  ? 26.16000 -48.84900 -15.19400 1.000 40.40524 ? 33  ASP A CA  1 
ATOM   247  C C   . ASP A 1 33  ? 27.61900 -49.30400 -15.19800 1.000 43.01617 ? 33  ASP A C   1 
ATOM   248  O O   . ASP A 1 33  ? 28.27100 -49.24700 -14.14300 1.000 42.18324 ? 33  ASP A O   1 
ATOM   249  C CB  . ASP A 1 33  ? 25.49300 -48.74600 -16.56100 1.000 36.28711 ? 33  ASP A CB  1 
ATOM   250  C CG  . ASP A 1 33  ? 24.06100 -48.24500 -16.47500 1.000 46.45104 ? 33  ASP A CG  1 
ATOM   251  O OD1 . ASP A 1 33  ? 23.39300 -48.52000 -15.45500 1.000 49.93220 ? 33  ASP A OD1 1 
ATOM   252  O OD2 . ASP A 1 33  ? 23.59900 -47.58100 -17.42800 1.000 44.15853 ? 33  ASP A OD2 1 
ATOM   253  N N   . ASP A 1 34  ? 28.17300 -49.73400 -16.33200 1.000 38.77415 ? 34  ASP A N   1 
ATOM   254  C CA  . ASP A 1 34  ? 29.55800 -50.17800 -16.41400 1.000 39.40883 ? 34  ASP A CA  1 
ATOM   255  C C   . ASP A 1 34  ? 30.44400 -49.15200 -17.11600 1.000 41.19617 ? 34  ASP A C   1 
ATOM   256  O O   . ASP A 1 34  ? 31.40700 -49.51400 -17.79600 1.000 40.33593 ? 34  ASP A O   1 
ATOM   257  C CB  . ASP A 1 34  ? 29.64700 -51.53000 -17.12200 1.000 40.34321 ? 34  ASP A CB  1 
ATOM   258  C CG  . ASP A 1 34  ? 29.02600 -51.50600 -18.50300 1.000 40.92502 ? 34  ASP A CG  1 
ATOM   259  O OD1 . ASP A 1 34  ? 28.37300 -50.50100 -18.85000 1.000 52.60731 ? 34  ASP A OD1 1 
ATOM   260  O OD2 . ASP A 1 34  ? 29.18900 -52.49400 -19.24500 1.000 46.61047 ? 34  ASP A OD2 1 
ATOM   261  N N   . VAL A 1 35  ? 30.12300 -47.86900 -16.96300 1.000 41.26748 ? 35  VAL A N   1 
ATOM   262  C CA  . VAL A 1 35  ? 30.86400 -46.78200 -17.58900 1.000 35.03311 ? 35  VAL A CA  1 
ATOM   263  C C   . VAL A 1 35  ? 31.21800 -45.76100 -16.51700 1.000 34.54606 ? 35  VAL A C   1 
ATOM   264  O O   . VAL A 1 35  ? 30.41300 -45.48300 -15.62000 1.000 34.44132 ? 35  VAL A O   1 
ATOM   265  C CB  . VAL A 1 35  ? 30.05000 -46.12300 -18.72600 1.000 33.62942 ? 35  VAL A CB  1 
ATOM   266  C CG1 . VAL A 1 35  ? 30.86400 -45.03800 -19.42100 1.000 32.95452 ? 35  VAL A CG1 1 
ATOM   267  C CG2 . VAL A 1 35  ? 29.57400 -47.16700 -19.72400 1.000 26.15775 ? 35  VAL A CG2 1 
ATOM   268  N N   . VAL A 1 36  ? 32.42500 -45.20800 -16.60100 1.000 35.95065 ? 36  VAL A N   1 
ATOM   269  C CA  . VAL A 1 36  ? 32.86500 -44.13900 -15.71200 1.000 32.42429 ? 36  VAL A CA  1 
ATOM   270  C C   . VAL A 1 36  ? 33.14100 -42.91100 -16.56700 1.000 34.39079 ? 36  VAL A C   1 
ATOM   271  O O   . VAL A 1 36  ? 33.92700 -42.97600 -17.52100 1.000 36.15425 ? 36  VAL A O   1 
ATOM   272  C CB  . VAL A 1 36  ? 34.10400 -44.54000 -14.89700 1.000 33.91255 ? 36  VAL A CB  1 
ATOM   273  C CG1 . VAL A 1 36  ? 34.63800 -43.34900 -14.11500 1.000 29.91794 ? 36  VAL A CG1 1 
ATOM   274  C CG2 . VAL A 1 36  ? 33.76000 -45.67900 -13.95400 1.000 35.00627 ? 36  VAL A CG2 1 
ATOM   275  N N   . TYR A 1 37  ? 32.48100 -41.80500 -16.23800 1.000 32.79748 ? 37  TYR A N   1 
ATOM   276  C CA  . TYR A 1 37  ? 32.63200 -40.54200 -16.94900 1.000 28.53950 ? 37  TYR A CA  1 
ATOM   277  C C   . TYR A 1 37  ? 33.49100 -39.60300 -16.11400 1.000 28.28797 ? 37  TYR A C   1 
ATOM   278  O O   . TYR A 1 37  ? 33.28300 -39.48400 -14.90400 1.000 29.69433 ? 37  TYR A O   1 
ATOM   279  C CB  . TYR A 1 37  ? 31.26800 -39.90200 -17.21900 1.000 30.92483 ? 37  TYR A CB  1 
ATOM   280  C CG  . TYR A 1 37  ? 30.28000 -40.80600 -17.92100 1.000 30.64465 ? 37  TYR A CG  1 
ATOM   281  C CD1 . TYR A 1 37  ? 29.55000 -41.75600 -17.21600 1.000 30.14870 ? 37  TYR A CD1 1 
ATOM   282  C CD2 . TYR A 1 37  ? 30.07200 -40.70500 -19.29000 1.000 32.51333 ? 37  TYR A CD2 1 
ATOM   283  C CE1 . TYR A 1 37  ? 28.64700 -42.58500 -17.85800 1.000 28.43279 ? 37  TYR A CE1 1 
ATOM   284  C CE2 . TYR A 1 37  ? 29.17100 -41.52600 -19.93900 1.000 26.97916 ? 37  TYR A CE2 1 
ATOM   285  C CZ  . TYR A 1 37  ? 28.46100 -42.46300 -19.22100 1.000 31.94202 ? 37  TYR A CZ  1 
ATOM   286  O OH  . TYR A 1 37  ? 27.56100 -43.28100 -19.87100 1.000 32.49889 ? 37  TYR A OH  1 
ATOM   287  N N   . CYS A 1 38  ? 34.45000 -38.94200 -16.75700 1.000 30.87753 ? 38  CYS A N   1 
ATOM   288  C CA  . CYS A 1 38  ? 35.32500 -37.99400 -16.08200 1.000 32.60298 ? 38  CYS A CA  1 
ATOM   289  C C   . CYS A 1 38  ? 35.90500 -37.04900 -17.12500 1.000 29.09129 ? 38  CYS A C   1 
ATOM   290  O O   . CYS A 1 38  ? 35.97000 -37.39600 -18.30900 1.000 32.53333 ? 38  CYS A O   1 
ATOM   291  C CB  . CYS A 1 38  ? 36.45000 -38.71600 -15.31900 1.000 32.94882 ? 38  CYS A CB  1 
ATOM   292  S SG  . CYS A 1 38  ? 37.79500 -39.32400 -16.36200 1.000 33.77940 ? 38  CYS A SG  1 
ATOM   293  N N   . PRO A 1 39  ? 36.33800 -35.85300 -16.72100 1.000 30.24915 ? 39  PRO A N   1 
ATOM   294  C CA  . PRO A 1 39  ? 36.96200 -34.93500 -17.68300 1.000 29.36622 ? 39  PRO A CA  1 
ATOM   295  C C   . PRO A 1 39  ? 38.19300 -35.55500 -18.32800 1.000 32.24364 ? 39  PRO A C   1 
ATOM   296  O O   . PRO A 1 39  ? 38.90200 -36.36400 -17.72400 1.000 31.35332 ? 39  PRO A O   1 
ATOM   297  C CB  . PRO A 1 39  ? 37.33300 -33.71900 -16.82500 1.000 29.96284 ? 39  PRO A CB  1 
ATOM   298  C CG  . PRO A 1 39  ? 36.40900 -33.79100 -15.65300 1.000 30.18379 ? 39  PRO A CG  1 
ATOM   299  C CD  . PRO A 1 39  ? 36.22700 -35.25200 -15.38100 1.000 29.43065 ? 39  PRO A CD  1 
ATOM   300  N N   . ARG A 1 40  ? 38.44400 -35.16700 -19.57800 1.000 30.73519 ? 40  ARG A N   1 
ATOM   301  C CA  . ARG A 1 40  ? 39.52300 -35.79000 -20.33000 1.000 30.24722 ? 40  ARG A CA  1 
ATOM   302  C C   . ARG A 1 40  ? 40.89900 -35.25400 -19.95900 1.000 34.16724 ? 40  ARG A C   1 
ATOM   303  O O   . ARG A 1 40  ? 41.90100 -35.90100 -20.28100 1.000 34.60228 ? 40  ARG A O   1 
ATOM   304  C CB  . ARG A 1 40  ? 39.29000 -35.62500 -21.83500 1.000 29.64916 ? 40  ARG A CB  1 
ATOM   305  C CG  . ARG A 1 40  ? 39.40100 -34.20100 -22.34900 1.000 28.78038 ? 40  ARG A CG  1 
ATOM   306  C CD  . ARG A 1 40  ? 39.29100 -34.16100 -23.86800 1.000 25.79205 ? 40  ARG A CD  1 
ATOM   307  N NE  . ARG A 1 40  ? 39.17100 -32.79600 -24.36400 1.000 28.35621 ? 40  ARG A NE  1 
ATOM   308  C CZ  . ARG A 1 40  ? 39.11600 -32.46300 -25.64600 1.000 32.12826 ? 40  ARG A CZ  1 
ATOM   309  N NH1 . ARG A 1 40  ? 39.16800 -33.37700 -26.60000 1.000 37.15426 ? 40  ARG A NH1 1 
ATOM   310  N NH2 . ARG A 1 40  ? 39.01500 -31.17900 -25.97900 1.000 29.74856 ? 40  ARG A NH2 1 
ATOM   311  N N   . HIS A 1 41  ? 40.98500 -34.10800 -19.28000 1.000 30.43924 ? 41  HIS A N   1 
ATOM   312  C CA  . HIS A 1 41  ? 42.29000 -33.58100 -18.90000 1.000 29.74341 ? 41  HIS A CA  1 
ATOM   313  C C   . HIS A 1 41  ? 42.90500 -34.32300 -17.71600 1.000 35.83450 ? 41  HIS A C   1 
ATOM   314  O O   . HIS A 1 41  ? 43.93600 -33.88600 -17.19100 1.000 33.69208 ? 41  HIS A O   1 
ATOM   315  C CB  . HIS A 1 41  ? 42.21200 -32.07800 -18.60700 1.000 25.23355 ? 41  HIS A CB  1 
ATOM   316  C CG  . HIS A 1 41  ? 41.45900 -31.72500 -17.36100 1.000 31.31300 ? 41  HIS A CG  1 
ATOM   317  N ND1 . HIS A 1 41  ? 40.21300 -31.13500 -17.38800 1.000 31.61687 ? 41  HIS A ND1 1 
ATOM   318  C CD2 . HIS A 1 41  ? 41.79100 -31.83800 -16.05300 1.000 29.24946 ? 41  HIS A CD2 1 
ATOM   319  C CE1 . HIS A 1 41  ? 39.80200 -30.92000 -16.15100 1.000 33.60859 ? 41  HIS A CE1 1 
ATOM   320  N NE2 . HIS A 1 41  ? 40.74000 -31.33900 -15.32200 1.000 31.04121 ? 41  HIS A NE2 1 
ATOM   321  N N   . VAL A 1 42  ? 42.30300 -35.43700 -17.29200 1.000 29.30507 ? 42  VAL A N   1 
ATOM   322  C CA  . VAL A 1 42  ? 42.97100 -36.32200 -16.34900 1.000 36.20687 ? 42  VAL A CA  1 
ATOM   323  C C   . VAL A 1 42  ? 44.21700 -36.94300 -16.97300 1.000 38.63180 ? 42  VAL A C   1 
ATOM   324  O O   . VAL A 1 42  ? 45.12200 -37.37500 -16.24900 1.000 43.01603 ? 42  VAL A O   1 
ATOM   325  C CB  . VAL A 1 42  ? 41.99300 -37.40600 -15.84900 1.000 30.97519 ? 42  VAL A CB  1 
ATOM   326  C CG1 . VAL A 1 42  ? 41.66100 -38.39100 -16.96100 1.000 27.91447 ? 42  VAL A CG1 1 
ATOM   327  C CG2 . VAL A 1 42  ? 42.55200 -38.12200 -14.62400 1.000 32.58792 ? 42  VAL A CG2 1 
ATOM   328  N N   . ILE A 1 43  ? 44.29600 -36.98800 -18.30900 1.000 37.28296 ? 43  ILE A N   1 
ATOM   329  C CA  . ILE A 1 43  ? 45.47000 -37.52800 -18.98700 1.000 36.34195 ? 43  ILE A CA  1 
ATOM   330  C C   . ILE A 1 43  ? 46.55800 -36.48300 -19.17700 1.000 31.22389 ? 43  ILE A C   1 
ATOM   331  O O   . ILE A 1 43  ? 47.62100 -36.80400 -19.72200 1.000 39.19640 ? 43  ILE A O   1 
ATOM   332  C CB  . ILE A 1 43  ? 45.09200 -38.13100 -20.35700 1.000 35.83083 ? 43  ILE A CB  1 
ATOM   333  C CG1 . ILE A 1 43  ? 44.78600 -37.02300 -21.36600 1.000 33.23164 ? 43  ILE A CG1 1 
ATOM   334  C CG2 . ILE A 1 43  ? 43.89800 -39.07400 -20.22000 1.000 30.59891 ? 43  ILE A CG2 1 
ATOM   335  C CD1 . ILE A 1 43  ? 44.43600 -37.53600 -22.74800 1.000 30.74206 ? 43  ILE A CD1 1 
ATOM   336  N N   . CYS A 1 44  ? 46.33200 -35.24800 -18.74000 1.000 39.32497 ? 44  CYS A N   1 
ATOM   337  C CA  . CYS A 1 44  ? 47.28500 -34.16400 -18.93900 1.000 36.92752 ? 44  CYS A CA  1 
ATOM   338  C C   . CYS A 1 44  ? 48.27200 -34.08000 -17.78400 1.000 40.94881 ? 44  CYS A C   1 
ATOM   339  O O   . CYS A 1 44  ? 47.89400 -34.20700 -16.61600 1.000 42.38804 ? 44  CYS A O   1 
ATOM   340  C CB  . CYS A 1 44  ? 46.56000 -32.82500 -19.07300 1.000 31.20254 ? 44  CYS A CB  1 
ATOM   341  S SG  . CYS A 1 44  ? 45.67300 -32.59400 -20.60800 1.000 37.89368 ? 44  CYS A SG  1 
ATOM   342  N N   . THR A 1 45  ? 49.53800 -33.85200 -18.11800 1.000 41.36237 ? 45  THR A N   1 
ATOM   343  C CA  . THR A 1 45  ? 50.51200 -33.47300 -17.11000 1.000 46.47276 ? 45  THR A CA  1 
ATOM   344  C C   . THR A 1 45  ? 50.38700 -31.98100 -16.82000 1.000 49.01141 ? 45  THR A C   1 
ATOM   345  O O   . THR A 1 45  ? 49.62100 -31.25800 -17.46400 1.000 52.21381 ? 45  THR A O   1 
ATOM   346  C CB  . THR A 1 45  ? 51.92800 -33.81400 -17.56400 1.000 44.24583 ? 45  THR A CB  1 
ATOM   347  O OG1 . THR A 1 45  ? 52.32300 -32.91100 -18.60400 1.000 51.84393 ? 45  THR A OG1 1 
ATOM   348  C CG2 . THR A 1 45  ? 51.99200 -35.24000 -18.08200 1.000 36.71479 ? 45  THR A CG2 1 
ATOM   349  N N   . SER A 1 46  ? 51.16100 -31.50900 -15.83900 1.000 59.15234 ? 46  SER A N   1 
ATOM   350  C CA  . SER A 1 46  ? 51.12500 -30.09300 -15.48900 1.000 52.42960 ? 46  SER A CA  1 
ATOM   351  C C   . SER A 1 46  ? 51.55800 -29.21800 -16.65900 1.000 57.68849 ? 46  SER A C   1 
ATOM   352  O O   . SER A 1 46  ? 51.09000 -28.08200 -16.79100 1.000 59.20509 ? 46  SER A O   1 
ATOM   353  C CB  . SER A 1 46  ? 52.00700 -29.83100 -14.26900 1.000 57.59169 ? 46  SER A CB  1 
ATOM   354  O OG  . SER A 1 46  ? 51.76200 -28.54300 -13.73400 1.000 66.80093 ? 46  SER A OG  1 
ATOM   355  N N   . GLU A 1 47  ? 52.43400 -29.73400 -17.52400 1.000 53.58368 ? 47  GLU A N   1 
ATOM   356  C CA  . GLU A 1 47  ? 52.88000 -28.97600 -18.68700 1.000 53.68190 ? 47  GLU A CA  1 
ATOM   357  C C   . GLU A 1 47  ? 51.88900 -29.05700 -19.84100 1.000 52.35400 ? 47  GLU A C   1 
ATOM   358  O O   . GLU A 1 47  ? 51.72600 -28.07900 -20.58200 1.000 51.40135 ? 47  GLU A O   1 
ATOM   359  C CB  . GLU A 1 47  ? 54.25500 -29.48000 -19.13300 1.000 58.20604 ? 47  GLU A CB  1 
ATOM   360  C CG  . GLU A 1 47  ? 54.78300 -28.84900 -20.41000 1.000 64.18993 ? 47  GLU A CG  1 
ATOM   361  C CD  . GLU A 1 47  ? 56.15100 -29.38600 -20.79200 1.000 74.84057 ? 47  GLU A CD  1 
ATOM   362  O OE1 . GLU A 1 47  ? 56.71700 -30.18300 -20.01300 1.000 73.41584 ? 47  GLU A OE1 1 
ATOM   363  O OE2 . GLU A 1 47  ? 56.66000 -29.01300 -21.87100 1.000 79.80020 ? 47  GLU A OE2 1 
ATOM   364  N N   . ASP A 1 48  ? 51.21100 -30.19800 -19.99900 1.000 49.20060 ? 48  ASP A N   1 
ATOM   365  C CA  . ASP A 1 48  ? 50.32800 -30.39000 -21.14500 1.000 45.77378 ? 48  ASP A CA  1 
ATOM   366  C C   . ASP A 1 48  ? 49.13200 -29.44500 -21.12300 1.000 48.24403 ? 48  ASP A C   1 
ATOM   367  O O   . ASP A 1 48  ? 48.56000 -29.14900 -22.17900 1.000 50.75860 ? 48  ASP A O   1 
ATOM   368  C CB  . ASP A 1 48  ? 49.84200 -31.83800 -21.19500 1.000 44.14681 ? 48  ASP A CB  1 
ATOM   369  C CG  . ASP A 1 48  ? 50.92500 -32.80100 -21.63400 1.000 49.79424 ? 48  ASP A CG  1 
ATOM   370  O OD1 . ASP A 1 48  ? 51.80600 -32.38900 -22.42000 1.000 54.20900 ? 48  ASP A OD1 1 
ATOM   371  O OD2 . ASP A 1 48  ? 50.89300 -33.97000 -21.19500 1.000 43.21202 ? 48  ASP A OD2 1 
ATOM   372  N N   . MET A 1 49  ? 48.74100 -28.95800 -19.94500 1.000 48.57595 ? 49  MET A N   1 
ATOM   373  C CA  . MET A 1 49  ? 47.50400 -28.19600 -19.83200 1.000 45.04579 ? 49  MET A CA  1 
ATOM   374  C C   . MET A 1 49  ? 47.56700 -26.84100 -20.52400 1.000 43.88044 ? 49  MET A C   1 
ATOM   375  O O   . MET A 1 49  ? 46.51300 -26.24000 -20.75400 1.000 45.48824 ? 49  MET A O   1 
ATOM   376  C CB  . MET A 1 49  ? 47.13500 -28.02000 -18.35800 1.000 39.89557 ? 49  MET A CB  1 
ATOM   377  C CG  . MET A 1 49  ? 46.77600 -29.32300 -17.66900 1.000 38.78988 ? 49  MET A CG  1 
ATOM   378  S SD  . MET A 1 49  ? 46.36100 -29.12700 -15.92800 1.000 56.66003 ? 49  MET A SD  1 
ATOM   379  C CE  . MET A 1 49  ? 45.74800 -30.76700 -15.53900 1.000 36.80405 ? 49  MET A CE  1 
ATOM   380  N N   . LEU A 1 50  ? 48.75900 -26.35400 -20.87500 1.000 40.30506 ? 50  LEU A N   1 
ATOM   381  C CA  . LEU A 1 50  ? 48.85600 -25.05400 -21.53600 1.000 41.99447 ? 50  LEU A CA  1 
ATOM   382  C C   . LEU A 1 50  ? 48.32400 -25.11100 -22.96400 1.000 47.41488 ? 50  LEU A C   1 
ATOM   383  O O   . LEU A 1 50  ? 47.63300 -24.18800 -23.41200 1.000 43.37091 ? 50  LEU A O   1 
ATOM   384  C CB  . LEU A 1 50  ? 50.30200 -24.56600 -21.51800 1.000 47.35307 ? 50  LEU A CB  1 
ATOM   385  C CG  . LEU A 1 50  ? 50.81600 -24.09300 -20.15700 1.000 53.21051 ? 50  LEU A CG  1 
ATOM   386  C CD1 . LEU A 1 50  ? 52.29700 -23.74000 -20.22700 1.000 48.79774 ? 50  LEU A CD1 1 
ATOM   387  C CD2 . LEU A 1 50  ? 49.99900 -22.90200 -19.67800 1.000 44.13572 ? 50  LEU A CD2 1 
ATOM   388  N N   . ASN A 1 51  ? 48.63800 -26.17500 -23.69400 1.000 46.51364 ? 51  ASN A N   1 
ATOM   389  C CA  . ASN A 1 51  ? 48.13300 -26.34600 -25.04900 1.000 45.57605 ? 51  ASN A CA  1 
ATOM   390  C C   . ASN A 1 51  ? 48.08400 -27.83000 -25.38500 1.000 45.59532 ? 51  ASN A C   1 
ATOM   391  O O   . ASN A 1 51  ? 48.93700 -28.32700 -26.13000 1.000 50.42977 ? 51  ASN A O   1 
ATOM   392  C CB  . ASN A 1 51  ? 49.00600 -25.58700 -26.04900 1.000 51.16338 ? 51  ASN A CB  1 
ATOM   393  C CG  . ASN A 1 51  ? 48.36200 -25.47900 -27.41500 1.000 58.34693 ? 51  ASN A CG  1 
ATOM   394  O OD1 . ASN A 1 51  ? 47.17700 -25.77900 -27.58100 1.000 58.22494 ? 51  ASN A OD1 1 
ATOM   395  N ND2 . ASN A 1 51  ? 49.13800 -25.04400 -28.40200 1.000 57.74698 ? 51  ASN A ND2 1 
ATOM   396  N N   . PRO A 1 52  ? 47.10900 -28.56800 -24.86100 1.000 43.46748 ? 52  PRO A N   1 
ATOM   397  C CA  . PRO A 1 52  ? 47.12100 -30.02500 -25.02200 1.000 38.52596 ? 52  PRO A CA  1 
ATOM   398  C C   . PRO A 1 52  ? 46.53200 -30.47200 -26.34900 1.000 36.44531 ? 52  PRO A C   1 
ATOM   399  O O   . PRO A 1 52  ? 45.55000 -29.91500 -26.84400 1.000 39.18811 ? 52  PRO A O   1 
ATOM   400  C CB  . PRO A 1 52  ? 46.25700 -30.50800 -23.85200 1.000 42.30571 ? 52  PRO A CB  1 
ATOM   401  C CG  . PRO A 1 52  ? 45.27300 -29.40000 -23.66500 1.000 43.47191 ? 52  PRO A CG  1 
ATOM   402  C CD  . PRO A 1 52  ? 45.98700 -28.11500 -24.01900 1.000 43.20065 ? 52  PRO A CD  1 
ATOM   403  N N   . ASN A 1 53  ? 47.15200 -31.49900 -26.92200 1.000 33.60399 ? 53  ASN A N   1 
ATOM   404  C CA  . ASN A 1 53  ? 46.59600 -32.22700 -28.06000 1.000 34.47627 ? 53  ASN A CA  1 
ATOM   405  C C   . ASN A 1 53  ? 46.04400 -33.53500 -27.49800 1.000 36.96062 ? 53  ASN A C   1 
ATOM   406  O O   . ASN A 1 53  ? 46.75800 -34.53400 -27.38500 1.000 33.88463 ? 53  ASN A O   1 
ATOM   407  C CB  . ASN A 1 53  ? 47.65500 -32.45400 -29.13500 1.000 35.17770 ? 53  ASN A CB  1 
ATOM   408  C CG  . ASN A 1 53  ? 47.06900 -32.96500 -30.43800 1.000 37.20327 ? 53  ASN A CG  1 
ATOM   409  O OD1 . ASN A 1 53  ? 46.09700 -33.72300 -30.44400 1.000 41.78549 ? 53  ASN A OD1 1 
ATOM   410  N ND2 . ASN A 1 53  ? 47.66300 -32.55300 -31.55200 1.000 38.16408 ? 53  ASN A ND2 1 
ATOM   411  N N   . TYR A 1 54  ? 44.75500 -33.52100 -27.13800 1.000 33.51034 ? 54  TYR A N   1 
ATOM   412  C CA  . TYR A 1 54  ? 44.16800 -34.66400 -26.44600 1.000 39.35675 ? 54  TYR A CA  1 
ATOM   413  C C   . TYR A 1 54  ? 44.20100 -35.92500 -27.29800 1.000 38.16090 ? 54  TYR A C   1 
ATOM   414  O O   . TYR A 1 54  ? 44.30200 -37.03300 -26.76100 1.000 39.10989 ? 54  TYR A O   1 
ATOM   415  C CB  . TYR A 1 54  ? 42.73500 -34.34000 -26.01700 1.000 36.22070 ? 54  TYR A CB  1 
ATOM   416  C CG  . TYR A 1 54  ? 42.67200 -33.32800 -24.89800 1.000 35.97949 ? 54  TYR A CG  1 
ATOM   417  C CD1 . TYR A 1 54  ? 42.93700 -33.70100 -23.58800 1.000 33.60830 ? 54  TYR A CD1 1 
ATOM   418  C CD2 . TYR A 1 54  ? 42.35500 -31.99900 -25.15000 1.000 33.30734 ? 54  TYR A CD2 1 
ATOM   419  C CE1 . TYR A 1 54  ? 42.88500 -32.78100 -22.56000 1.000 33.13705 ? 54  TYR A CE1 1 
ATOM   420  C CE2 . TYR A 1 54  ? 42.29500 -31.07500 -24.12500 1.000 31.67654 ? 54  TYR A CE2 1 
ATOM   421  C CZ  . TYR A 1 54  ? 42.56300 -31.47400 -22.83500 1.000 32.43534 ? 54  TYR A CZ  1 
ATOM   422  O OH  . TYR A 1 54  ? 42.51600 -30.56400 -21.81000 1.000 35.24975 ? 54  TYR A OH  1 
ATOM   423  N N   A GLU A 1 55  ? 44.08800 -35.78300 -28.61900 0.631 38.70942 ? 55  GLU A N   1 
ATOM   424  N N   B GLU A 1 55  ? 44.10700 -35.78500 -28.62100 0.369 38.74081 ? 55  GLU A N   1 
ATOM   425  C CA  A GLU A 1 55  ? 44.19500 -36.94700 -29.49000 0.631 39.43918 ? 55  GLU A CA  1 
ATOM   426  C CA  B GLU A 1 55  ? 44.19700 -36.94700 -29.49900 0.369 39.45300 ? 55  GLU A CA  1 
ATOM   427  C C   A GLU A 1 55  ? 45.57100 -37.59100 -29.37900 0.631 38.35036 ? 55  GLU A C   1 
ATOM   428  C C   B GLU A 1 55  ? 45.57100 -37.59500 -29.39300 0.369 38.41285 ? 55  GLU A C   1 
ATOM   429  O O   A GLU A 1 55  ? 45.68600 -38.81400 -29.25200 0.631 40.05208 ? 55  GLU A O   1 
ATOM   430  O O   B GLU A 1 55  ? 45.68300 -38.81400 -29.22200 0.369 40.03081 ? 55  GLU A O   1 
ATOM   431  C CB  A GLU A 1 55  ? 43.90500 -36.55600 -30.93600 0.631 41.13014 ? 55  GLU A CB  1 
ATOM   432  C CB  B GLU A 1 55  ? 43.88400 -36.52400 -30.93500 0.369 41.12459 ? 55  GLU A CB  1 
ATOM   433  C CG  A GLU A 1 55  ? 42.57400 -35.87500 -31.13100 0.631 41.76126 ? 55  GLU A CG  1 
ATOM   434  C CG  B GLU A 1 55  ? 43.99100 -37.62000 -31.96600 0.369 44.28189 ? 55  GLU A CG  1 
ATOM   435  C CD  A GLU A 1 55  ? 42.56600 -34.44300 -30.62200 0.631 42.28743 ? 55  GLU A CD  1 
ATOM   436  C CD  B GLU A 1 55  ? 43.75400 -37.10000 -33.38300 0.369 44.95093 ? 55  GLU A CD  1 
ATOM   437  O OE1 A GLU A 1 55  ? 43.32100 -33.60700 -31.16000 0.631 41.96414 ? 55  GLU A OE1 1 
ATOM   438  O OE1 B GLU A 1 55  ? 43.32000 -35.94300 -33.55000 0.369 44.70214 ? 55  GLU A OE1 1 
ATOM   439  O OE2 A GLU A 1 55  ? 41.80000 -34.14800 -29.68200 0.631 43.10319 ? 55  GLU A OE2 1 
ATOM   440  O OE2 B GLU A 1 55  ? 44.01600 -37.83700 -34.34900 0.369 43.81714 ? 55  GLU A OE2 1 
ATOM   441  N N   . ASP A 1 56  ? 46.63100 -36.78300 -29.44100 1.000 36.42399 ? 56  ASP A N   1 
ATOM   442  C CA  . ASP A 1 56  ? 47.98100 -37.32400 -29.31500 1.000 40.06186 ? 56  ASP A CA  1 
ATOM   443  C C   . ASP A 1 56  ? 48.28300 -37.77800 -27.88900 1.000 41.22418 ? 56  ASP A C   1 
ATOM   444  O O   . ASP A 1 56  ? 49.04900 -38.73000 -27.69700 1.000 42.39915 ? 56  ASP A O   1 
ATOM   445  C CB  . ASP A 1 56  ? 49.01500 -36.28800 -29.76200 1.000 38.35939 ? 56  ASP A CB  1 
ATOM   446  C CG  . ASP A 1 56  ? 48.91500 -35.94600 -31.23700 1.000 41.17527 ? 56  ASP A CG  1 
ATOM   447  O OD1 . ASP A 1 56  ? 48.08700 -36.54900 -31.95900 1.000 39.16792 ? 56  ASP A OD1 1 
ATOM   448  O OD2 . ASP A 1 56  ? 49.67300 -35.06200 -31.67500 1.000 40.87413 ? 56  ASP A OD2 1 
ATOM   449  N N   . LEU A 1 57  ? 47.68800 -37.12700 -26.88400 1.000 40.41830 ? 57  LEU A N   1 
ATOM   450  C CA  . LEU A 1 57  ? 47.94700 -37.50800 -25.49700 1.000 38.24551 ? 57  LEU A CA  1 
ATOM   451  C C   . LEU A 1 57  ? 47.22200 -38.79400 -25.12700 1.000 38.84567 ? 57  LEU A C   1 
ATOM   452  O O   . LEU A 1 57  ? 47.78100 -39.65200 -24.43200 1.000 36.96322 ? 57  LEU A O   1 
ATOM   453  C CB  . LEU A 1 57  ? 47.53800 -36.38000 -24.54800 1.000 35.61066 ? 57  LEU A CB  1 
ATOM   454  C CG  . LEU A 1 57  ? 48.39000 -35.11400 -24.58800 1.000 41.11720 ? 57  LEU A CG  1 
ATOM   455  C CD1 . LEU A 1 57  ? 47.76200 -34.00600 -23.75600 1.000 34.05772 ? 57  LEU A CD1 1 
ATOM   456  C CD2 . LEU A 1 57  ? 49.80600 -35.41100 -24.11200 1.000 38.11145 ? 57  LEU A CD2 1 
ATOM   457  N N   . LEU A 1 58  ? 45.97700 -38.94800 -25.58400 1.000 44.04013 ? 58  LEU A N   1 
ATOM   458  C CA  . LEU A 1 58  ? 45.20800 -40.14500 -25.25700 1.000 40.62216 ? 58  LEU A CA  1 
ATOM   459  C C   . LEU A 1 58  ? 45.78600 -41.38600 -25.92300 1.000 38.49745 ? 58  LEU A C   1 
ATOM   460  O O   . LEU A 1 58  ? 45.69000 -42.48800 -25.37000 1.000 36.69595 ? 58  LEU A O   1 
ATOM   461  C CB  . LEU A 1 58  ? 43.74800 -39.95700 -25.66900 1.000 31.16148 ? 58  LEU A CB  1 
ATOM   462  C CG  . LEU A 1 58  ? 42.80200 -41.10000 -25.31700 1.000 34.04817 ? 58  LEU A CG  1 
ATOM   463  C CD1 . LEU A 1 58  ? 42.81100 -41.34200 -23.81600 1.000 37.66973 ? 58  LEU A CD1 1 
ATOM   464  C CD2 . LEU A 1 58  ? 41.40000 -40.79600 -25.81000 1.000 38.94936 ? 58  LEU A CD2 1 
ATOM   465  N N   . ILE A 1 59  ? 46.39400 -41.22500 -27.09900 1.000 41.36716 ? 59  ILE A N   1 
ATOM   466  C CA  . ILE A 1 59  ? 46.89800 -42.36700 -27.85600 1.000 38.63481 ? 59  ILE A CA  1 
ATOM   467  C C   . ILE A 1 59  ? 47.99700 -43.09400 -27.09300 1.000 44.24120 ? 59  ILE A C   1 
ATOM   468  O O   . ILE A 1 59  ? 48.12700 -44.32100 -27.19200 1.000 47.67485 ? 59  ILE A O   1 
ATOM   469  C CB  . ILE A 1 59  ? 47.36300 -41.89100 -29.24500 1.000 41.48858 ? 59  ILE A CB  1 
ATOM   470  C CG1 . ILE A 1 59  ? 46.16500 -41.84800 -30.19500 1.000 39.39602 ? 59  ILE A CG1 1 
ATOM   471  C CG2 . ILE A 1 59  ? 48.48600 -42.76400 -29.79200 1.000 42.58220 ? 59  ILE A CG2 1 
ATOM   472  C CD1 . ILE A 1 59  ? 46.45500 -41.18900 -31.49500 1.000 37.74314 ? 59  ILE A CD1 1 
ATOM   473  N N   . ARG A 1 60  ? 48.78000 -42.37000 -26.30100 1.000 40.30129 ? 60  ARG A N   1 
ATOM   474  C CA  . ARG A 1 60  ? 49.80900 -43.00200 -25.48900 1.000 39.34404 ? 60  ARG A CA  1 
ATOM   475  C C   . ARG A 1 60  ? 49.26900 -43.57100 -24.18000 1.000 46.71836 ? 60  ARG A C   1 
ATOM   476  O O   . ARG A 1 60  ? 50.06200 -43.90200 -23.29200 1.000 46.66457 ? 60  ARG A O   1 
ATOM   477  C CB  . ARG A 1 60  ? 50.93700 -42.00700 -25.21200 1.000 40.35066 ? 60  ARG A CB  1 
ATOM   478  C CG  . ARG A 1 60  ? 51.73100 -41.65300 -26.46200 1.000 44.65802 ? 60  ARG A CG  1 
ATOM   479  C CD  . ARG A 1 60  ? 53.02400 -40.94300 -26.11900 1.000 58.32730 ? 60  ARG A CD  1 
ATOM   480  N NE  . ARG A 1 60  ? 52.77900 -39.66600 -25.46200 1.000 60.39001 ? 60  ARG A NE  1 
ATOM   481  C CZ  . ARG A 1 60  ? 52.57700 -38.52400 -26.10400 1.000 64.41971 ? 60  ARG A CZ  1 
ATOM   482  N NH1 . ARG A 1 60  ? 52.57600 -38.46400 -27.42700 1.000 58.40292 ? 60  ARG A NH1 1 
ATOM   483  N NH2 . ARG A 1 60  ? 52.36800 -37.41400 -25.40100 1.000 68.24550 ? 60  ARG A NH2 1 
ATOM   484  N N   . LYS A 1 61  ? 47.95000 -43.70700 -24.04700 1.000 40.23573 ? 61  LYS A N   1 
ATOM   485  C CA  . LYS A 1 61  ? 47.32100 -44.20100 -22.83200 1.000 37.94382 ? 61  LYS A CA  1 
ATOM   486  C C   . LYS A 1 61  ? 46.58700 -45.50300 -23.11700 1.000 38.17307 ? 61  LYS A C   1 
ATOM   487  O O   . LYS A 1 61  ? 45.88200 -45.62300 -24.12400 1.000 37.98493 ? 61  LYS A O   1 
ATOM   488  C CB  . LYS A 1 61  ? 46.34000 -43.17000 -22.25500 1.000 36.74080 ? 61  LYS A CB  1 
ATOM   489  C CG  . LYS A 1 61  ? 46.88100 -42.36900 -21.08100 1.000 36.56417 ? 61  LYS A CG  1 
ATOM   490  C CD  . LYS A 1 61  ? 48.10300 -41.55900 -21.46500 1.000 36.09344 ? 61  LYS A CD  1 
ATOM   491  C CE  . LYS A 1 61  ? 48.59300 -40.73200 -20.29300 1.000 33.97826 ? 61  LYS A CE  1 
ATOM   492  N NZ  . LYS A 1 61  ? 48.90100 -41.59000 -19.12200 1.000 45.71587 ? 61  LYS A NZ  1 
ATOM   493  N N   . SER A 1 62  ? 46.75300 -46.47400 -22.22500 1.000 36.17086 ? 62  SER A N   1 
ATOM   494  C CA  . SER A 1 62  ? 46.06300 -47.75200 -22.29400 1.000 37.49538 ? 62  SER A CA  1 
ATOM   495  C C   . SER A 1 62  ? 45.08900 -47.86600 -21.12500 1.000 41.80035 ? 62  SER A C   1 
ATOM   496  O O   . SER A 1 62  ? 45.02900 -46.99800 -20.24900 1.000 41.15191 ? 62  SER A O   1 
ATOM   497  C CB  . SER A 1 62  ? 47.06400 -48.91200 -22.29600 1.000 37.32815 ? 62  SER A CB  1 
ATOM   498  O OG  . SER A 1 62  ? 47.93700 -48.84200 -23.41300 1.000 40.54590 ? 62  SER A OG  1 
ATOM   499  N N   . ASN A 1 63  ? 44.32300 -48.96000 -21.11700 1.000 38.90999 ? 63  ASN A N   1 
ATOM   500  C CA  . ASN A 1 63  ? 43.32600 -49.16200 -20.07000 1.000 39.04625 ? 63  ASN A CA  1 
ATOM   501  C C   . ASN A 1 63  ? 43.96300 -49.19800 -18.68600 1.000 37.38789 ? 63  ASN A C   1 
ATOM   502  O O   . ASN A 1 63  ? 43.43900 -48.59800 -17.74100 1.000 43.52220 ? 63  ASN A O   1 
ATOM   503  C CB  . ASN A 1 63  ? 42.54400 -50.45000 -20.32900 1.000 37.58092 ? 63  ASN A CB  1 
ATOM   504  C CG  . ASN A 1 63  ? 41.68800 -50.36800 -21.57300 1.000 43.43870 ? 63  ASN A CG  1 
ATOM   505  O OD1 . ASN A 1 63  ? 41.28800 -49.28400 -21.99500 1.000 42.83132 ? 63  ASN A OD1 1 
ATOM   506  N ND2 . ASN A 1 63  ? 41.39800 -51.51800 -22.16700 1.000 44.68948 ? 63  ASN A ND2 1 
ATOM   507  N N   . HIS A 1 64  ? 45.09300 -49.89200 -18.54400 1.000 36.68845 ? 64  HIS A N   1 
ATOM   508  C CA  . HIS A 1 64  ? 45.71100 -50.03000 -17.23000 1.000 39.83389 ? 64  HIS A CA  1 
ATOM   509  C C   . HIS A 1 64  ? 46.30900 -48.72600 -16.71600 1.000 36.29916 ? 64  HIS A C   1 
ATOM   510  O O   . HIS A 1 64  ? 46.63600 -48.64600 -15.52800 1.000 46.42748 ? 64  HIS A O   1 
ATOM   511  C CB  . HIS A 1 64  ? 46.78700 -51.12100 -17.25900 1.000 40.41164 ? 64  HIS A CB  1 
ATOM   512  C CG  . HIS A 1 64  ? 47.96200 -50.79300 -18.12400 1.000 35.49882 ? 64  HIS A CG  1 
ATOM   513  N ND1 . HIS A 1 64  ? 48.06600 -51.22000 -19.43000 1.000 41.53628 ? 64  HIS A ND1 1 
ATOM   514  C CD2 . HIS A 1 64  ? 49.08700 -50.08300 -17.86900 1.000 34.57016 ? 64  HIS A CD2 1 
ATOM   515  C CE1 . HIS A 1 64  ? 49.20200 -50.78300 -19.94400 1.000 43.77243 ? 64  HIS A CE1 1 
ATOM   516  N NE2 . HIS A 1 64  ? 49.84000 -50.09100 -19.01800 1.000 36.18377 ? 64  HIS A NE2 1 
ATOM   517  N N   . ASN A 1 65  ? 46.45600 -47.70900 -17.56600 1.000 38.17976 ? 65  ASN A N   1 
ATOM   518  C CA  . ASN A 1 65  ? 46.92600 -46.40600 -17.11400 1.000 39.45055 ? 65  ASN A CA  1 
ATOM   519  C C   . ASN A 1 65  ? 45.86600 -45.61500 -16.35800 1.000 38.98727 ? 65  ASN A C   1 
ATOM   520  O O   . ASN A 1 65  ? 46.16900 -44.52400 -15.86400 1.000 34.54984 ? 65  ASN A O   1 
ATOM   521  C CB  . ASN A 1 65  ? 47.41500 -45.57700 -18.30200 1.000 36.55900 ? 65  ASN A CB  1 
ATOM   522  C CG  . ASN A 1 65  ? 48.68500 -46.12400 -18.91000 1.000 41.93641 ? 65  ASN A CG  1 
ATOM   523  O OD1 . ASN A 1 65  ? 48.79800 -46.25100 -20.12900 1.000 46.99887 ? 65  ASN A OD1 1 
ATOM   524  N ND2 . ASN A 1 65  ? 49.65100 -46.45400 -18.06200 1.000 40.77963 ? 65  ASN A ND2 1 
ATOM   525  N N   . PHE A 1 66  ? 44.64000 -46.12300 -16.26300 1.000 40.09917 ? 66  PHE A N   1 
ATOM   526  C CA  . PHE A 1 66  ? 43.54600 -45.43700 -15.58300 1.000 42.57538 ? 66  PHE A CA  1 
ATOM   527  C C   . PHE A 1 66  ? 43.24200 -46.16900 -14.28100 1.000 41.21077 ? 66  PHE A C   1 
ATOM   528  O O   . PHE A 1 66  ? 42.76800 -47.31000 -14.29900 1.000 44.98464 ? 66  PHE A O   1 
ATOM   529  C CB  . PHE A 1 66  ? 42.30600 -45.36800 -16.47100 1.000 39.39486 ? 66  PHE A CB  1 
ATOM   530  C CG  . PHE A 1 66  ? 42.47500 -44.49700 -17.67800 1.000 39.44153 ? 66  PHE A CG  1 
ATOM   531  C CD1 . PHE A 1 66  ? 42.31100 -43.12300 -17.58500 1.000 43.09869 ? 66  PHE A CD1 1 
ATOM   532  C CD2 . PHE A 1 66  ? 42.79400 -45.04800 -18.90800 1.000 37.64180 ? 66  PHE A CD2 1 
ATOM   533  C CE1 . PHE A 1 66  ? 42.46300 -42.31500 -18.69800 1.000 41.60335 ? 66  PHE A CE1 1 
ATOM   534  C CE2 . PHE A 1 66  ? 42.94700 -44.24600 -20.02400 1.000 37.61720 ? 66  PHE A CE2 1 
ATOM   535  C CZ  . PHE A 1 66  ? 42.78300 -42.87600 -19.91800 1.000 35.10596 ? 66  PHE A CZ  1 
ATOM   536  N N   . LEU A 1 67  ? 43.50700 -45.51100 -13.15800 1.000 33.97915 ? 67  LEU A N   1 
ATOM   537  C CA  . LEU A 1 67  ? 43.23100 -46.06900 -11.83700 1.000 44.59659 ? 67  LEU A CA  1 
ATOM   538  C C   . LEU A 1 67  ? 41.87500 -45.54200 -11.37800 1.000 44.27078 ? 67  LEU A C   1 
ATOM   539  O O   . LEU A 1 67  ? 41.76000 -44.39700 -10.93300 1.000 42.44976 ? 67  LEU A O   1 
ATOM   540  C CB  . LEU A 1 67  ? 44.33700 -45.71300 -10.84700 1.000 44.45683 ? 67  LEU A CB  1 
ATOM   541  C CG  . LEU A 1 67  ? 45.65500 -46.48600 -10.95100 1.000 47.16736 ? 67  LEU A CG  1 
ATOM   542  C CD1 . LEU A 1 67  ? 45.39200 -47.98400 -11.05100 1.000 53.34702 ? 67  LEU A CD1 1 
ATOM   543  C CD2 . LEU A 1 67  ? 46.50900 -46.00100 -12.11900 1.000 54.25995 ? 67  LEU A CD2 1 
ATOM   544  N N   . VAL A 1 68  ? 40.84900 -46.37900 -11.49000 1.000 39.72822 ? 68  VAL A N   1 
ATOM   545  C CA  . VAL A 1 68  ? 39.49800 -46.03800 -11.06300 1.000 41.71785 ? 68  VAL A CA  1 
ATOM   546  C C   . VAL A 1 68  ? 39.25000 -46.69600 -9.71400  1.000 44.71261 ? 68  VAL A C   1 
ATOM   547  O O   . VAL A 1 68  ? 39.26200 -47.92800 -9.60400  1.000 46.50290 ? 68  VAL A O   1 
ATOM   548  C CB  . VAL A 1 68  ? 38.45100 -46.48200 -12.09500 1.000 42.86714 ? 68  VAL A CB  1 
ATOM   549  C CG1 . VAL A 1 68  ? 37.05800 -46.06100 -11.65000 1.000 41.08362 ? 68  VAL A CG1 1 
ATOM   550  C CG2 . VAL A 1 68  ? 38.77800 -45.91100 -13.46400 1.000 34.46276 ? 68  VAL A CG2 1 
ATOM   551  N N   . GLN A 1 69  ? 39.02900 -45.88200 -8.68500  1.000 46.10958 ? 69  GLN A N   1 
ATOM   552  C CA  . GLN A 1 69  ? 38.79600 -46.37500 -7.33300  1.000 50.61133 ? 69  GLN A CA  1 
ATOM   553  C C   . GLN A 1 69  ? 37.41200 -45.94700 -6.86700  1.000 50.24163 ? 69  GLN A C   1 
ATOM   554  O O   . GLN A 1 69  ? 37.08300 -44.75600 -6.89100  1.000 46.62666 ? 69  GLN A O   1 
ATOM   555  C CB  . GLN A 1 69  ? 39.86500 -45.86900 -6.36700  1.000 51.73975 ? 69  GLN A CB  1 
ATOM   556  C CG  . GLN A 1 69  ? 39.64100 -46.32000 -4.93700  1.000 60.83877 ? 69  GLN A CG  1 
ATOM   557  C CD  . GLN A 1 69  ? 40.90200 -46.26700 -4.10300  1.000 60.72966 ? 69  GLN A CD  1 
ATOM   558  O OE1 . GLN A 1 69  ? 41.97500 -45.92700 -4.60100  1.000 63.38619 ? 69  GLN A OE1 1 
ATOM   559  N NE2 . GLN A 1 69  ? 40.78000 -46.60700 -2.82600  1.000 66.35298 ? 69  GLN A NE2 1 
ATOM   560  N N   . ALA A 1 70  ? 36.61100 -46.91800 -6.44500  1.000 51.22976 ? 70  ALA A N   1 
ATOM   561  C CA  . ALA A 1 70  ? 35.28400 -46.68400 -5.88500  1.000 51.93548 ? 70  ALA A CA  1 
ATOM   562  C C   . ALA A 1 70  ? 35.35700 -47.05900 -4.40600  1.000 59.81161 ? 70  ALA A C   1 
ATOM   563  O O   . ALA A 1 70  ? 35.09000 -48.19900 -4.02400  1.000 61.41638 ? 70  ALA A O   1 
ATOM   564  C CB  . ALA A 1 70  ? 34.22300 -47.49400 -6.62400  1.000 48.26804 ? 70  ALA A CB  1 
ATOM   565  N N   . GLY A 1 71  ? 35.73600 -46.09000 -3.57700  1.000 56.64876 ? 71  GLY A N   1 
ATOM   566  C CA  . GLY A 1 71  ? 35.90200 -46.34600 -2.16000  1.000 55.54557 ? 71  GLY A CA  1 
ATOM   567  C C   . GLY A 1 71  ? 37.12900 -47.18100 -1.86000  1.000 63.08917 ? 71  GLY A C   1 
ATOM   568  O O   . GLY A 1 71  ? 38.26000 -46.69700 -1.97100  1.000 63.25663 ? 71  GLY A O   1 
ATOM   569  N N   . ASN A 1 72  ? 36.92100 -48.44300 -1.48300  1.000 61.23503 ? 72  ASN A N   1 
ATOM   570  C CA  . ASN A 1 72  ? 38.02600 -49.33700 -1.16200  1.000 71.18513 ? 72  ASN A CA  1 
ATOM   571  C C   . ASN A 1 72  ? 38.44100 -50.23600 -2.31800  1.000 67.61865 ? 72  ASN A C   1 
ATOM   572  O O   . ASN A 1 72  ? 39.58700 -50.69900 -2.33500  1.000 68.50147 ? 72  ASN A O   1 
ATOM   573  C CB  . ASN A 1 72  ? 37.67000 -50.22400 0.03900   1.000 77.14161 ? 72  ASN A CB  1 
ATOM   574  C CG  . ASN A 1 72  ? 37.84100 -49.51000 1.36300   1.000 84.34596 ? 72  ASN A CG  1 
ATOM   575  O OD1 . ASN A 1 72  ? 38.54900 -48.50600 1.45400   1.000 87.13979 ? 72  ASN A OD1 1 
ATOM   576  N ND2 . ASN A 1 72  ? 37.19700 -50.03100 2.40300   1.000 80.99142 ? 72  ASN A ND2 1 
ATOM   577  N N   . VAL A 1 73  ? 37.55500 -50.49300 -3.27300  1.000 60.88320 ? 73  VAL A N   1 
ATOM   578  C CA  . VAL A 1 73  ? 37.82400 -51.45000 -4.33900  1.000 64.40816 ? 73  VAL A CA  1 
ATOM   579  C C   . VAL A 1 73  ? 38.13700 -50.70300 -5.62700  1.000 65.51485 ? 73  VAL A C   1 
ATOM   580  O O   . VAL A 1 73  ? 37.62800 -49.60200 -5.87900  1.000 60.35986 ? 73  VAL A O   1 
ATOM   581  C CB  . VAL A 1 73  ? 36.63700 -52.42300 -4.52300  1.000 63.84924 ? 73  VAL A CB  1 
ATOM   582  C CG1 . VAL A 1 73  ? 35.43600 -51.70900 -5.12800  1.000 62.96735 ? 73  VAL A CG1 1 
ATOM   583  C CG2 . VAL A 1 73  ? 37.04800 -53.62600 -5.36900  1.000 68.68474 ? 73  VAL A CG2 1 
ATOM   584  N N   . GLN A 1 74  ? 39.00300 -51.30000 -6.44300  1.000 61.67672 ? 74  GLN A N   1 
ATOM   585  C CA  . GLN A 1 74  ? 39.29500 -50.78700 -7.77200  1.000 59.07003 ? 74  GLN A CA  1 
ATOM   586  C C   . GLN A 1 74  ? 38.28700 -51.31900 -8.78100  1.000 58.39044 ? 74  GLN A C   1 
ATOM   587  O O   . GLN A 1 74  ? 37.59900 -52.31500 -8.55000  1.000 58.90430 ? 74  GLN A O   1 
ATOM   588  C CB  . GLN A 1 74  ? 40.70200 -51.17700 -8.22100  1.000 54.80772 ? 74  GLN A CB  1 
ATOM   589  C CG  . GLN A 1 74  ? 41.81200 -50.62800 -7.36500  1.000 58.86737 ? 74  GLN A CG  1 
ATOM   590  C CD  . GLN A 1 74  ? 41.93500 -49.11900 -7.43800  1.000 67.57084 ? 74  GLN A CD  1 
ATOM   591  O OE1 . GLN A 1 74  ? 41.89900 -48.43300 -6.41700  1.000 77.18709 ? 74  GLN A OE1 1 
ATOM   592  N NE2 . GLN A 1 74  ? 42.09700 -48.59400 -8.64800  1.000 65.43109 ? 74  GLN A NE2 1 
ATOM   593  N N   . LEU A 1 75  ? 38.21500 -50.63700 -9.91700  1.000 50.97111 ? 75  LEU A N   1 
ATOM   594  C CA  . LEU A 1 75  ? 37.46400 -51.10400 -11.07000 1.000 46.89804 ? 75  LEU A CA  1 
ATOM   595  C C   . LEU A 1 75  ? 38.44800 -51.42700 -12.18100 1.000 48.94213 ? 75  LEU A C   1 
ATOM   596  O O   . LEU A 1 75  ? 39.34000 -50.62400 -12.48000 1.000 50.96989 ? 75  LEU A O   1 
ATOM   597  C CB  . LEU A 1 75  ? 36.45300 -50.05900 -11.54300 1.000 51.80078 ? 75  LEU A CB  1 
ATOM   598  C CG  . LEU A 1 75  ? 35.30700 -49.70900 -10.59500 1.000 46.86932 ? 75  LEU A CG  1 
ATOM   599  C CD1 . LEU A 1 75  ? 34.29600 -48.84200 -11.31900 1.000 45.39198 ? 75  LEU A CD1 1 
ATOM   600  C CD2 . LEU A 1 75  ? 34.65500 -50.96800 -10.05400 1.000 47.10556 ? 75  LEU A CD2 1 
ATOM   601  N N   . ARG A 1 76  ? 38.29800 -52.60300 -12.77500 1.000 40.96517 ? 76  ARG A N   1 
ATOM   602  C CA  . ARG A 1 76  ? 39.14200 -52.99500 -13.89200 1.000 47.79534 ? 76  ARG A CA  1 
ATOM   603  C C   . ARG A 1 76  ? 38.64800 -52.29800 -15.15400 1.000 46.44465 ? 76  ARG A C   1 
ATOM   604  O O   . ARG A 1 76  ? 37.51300 -52.52100 -15.58800 1.000 44.68215 ? 76  ARG A O   1 
ATOM   605  C CB  . ARG A 1 76  ? 39.12900 -54.51200 -14.05600 1.000 49.41835 ? 76  ARG A CB  1 
ATOM   606  C CG  . ARG A 1 76  ? 40.10700 -55.03900 -15.08400 1.000 46.98875 ? 76  ARG A CG  1 
ATOM   607  C CD  . ARG A 1 76  ? 39.99000 -56.54800 -15.19600 1.000 57.29991 ? 76  ARG A CD  1 
ATOM   608  N NE  . ARG A 1 76  ? 40.18100 -57.19800 -13.90500 1.000 57.37654 ? 76  ARG A NE  1 
ATOM   609  C CZ  . ARG A 1 76  ? 41.36000 -57.55800 -13.41900 1.000 44.81585 ? 76  ARG A CZ  1 
ATOM   610  N NH1 . ARG A 1 76  ? 42.47800 -57.34600 -14.09400 1.000 38.01415 ? 76  ARG A NH1 1 
ATOM   611  N NH2 . ARG A 1 76  ? 41.41900 -58.14500 -12.22600 1.000 45.58892 ? 76  ARG A NH2 1 
ATOM   612  N N   . VAL A 1 77  ? 39.48900 -51.44200 -15.72700 1.000 46.47514 ? 77  VAL A N   1 
ATOM   613  C CA  . VAL A 1 77  ? 39.15400 -50.74900 -16.96600 1.000 42.05248 ? 77  VAL A CA  1 
ATOM   614  C C   . VAL A 1 77  ? 39.34200 -51.71100 -18.13000 1.000 44.27110 ? 77  VAL A C   1 
ATOM   615  O O   . VAL A 1 77  ? 40.40100 -52.33500 -18.27200 1.000 44.39089 ? 77  VAL A O   1 
ATOM   616  C CB  . VAL A 1 77  ? 40.01900 -49.49000 -17.13600 1.000 41.90838 ? 77  VAL A CB  1 
ATOM   617  C CG1 . VAL A 1 77  ? 39.62700 -48.73700 -18.40100 1.000 36.64580 ? 77  VAL A CG1 1 
ATOM   618  C CG2 . VAL A 1 77  ? 39.89500 -48.59200 -15.91200 1.000 41.47354 ? 77  VAL A CG2 1 
ATOM   619  N N   . ILE A 1 78  ? 38.31200 -51.84100 -18.96300 1.000 41.04615 ? 78  ILE A N   1 
ATOM   620  C CA  . ILE A 1 78  ? 38.34400 -52.75100 -20.09900 1.000 39.83192 ? 78  ILE A CA  1 
ATOM   621  C C   . ILE A 1 78  ? 38.07000 -52.01600 -21.41200 1.000 41.23271 ? 78  ILE A C   1 
ATOM   622  O O   . ILE A 1 78  ? 37.74400 -52.63800 -22.41600 1.000 44.33700 ? 78  ILE A O   1 
ATOM   623  C CB  . ILE A 1 78  ? 37.36200 -53.92100 -19.89600 1.000 37.27239 ? 78  ILE A CB  1 
ATOM   624  C CG1 . ILE A 1 78  ? 35.92300 -53.41300 -19.82600 1.000 45.06200 ? 78  ILE A CG1 1 
ATOM   625  C CG2 . ILE A 1 78  ? 37.69200 -54.67500 -18.61900 1.000 38.45003 ? 78  ILE A CG2 1 
ATOM   626  C CD1 . ILE A 1 78  ? 34.89400 -54.51800 -19.64700 1.000 43.13597 ? 78  ILE A CD1 1 
ATOM   627  N N   . GLY A 1 79  ? 38.20900 -50.69300 -21.41200 1.000 44.13079 ? 79  GLY A N   1 
ATOM   628  C CA  . GLY A 1 79  ? 37.95000 -49.89900 -22.59700 1.000 38.33973 ? 79  GLY A CA  1 
ATOM   629  C C   . GLY A 1 79  ? 37.88500 -48.41500 -22.29900 1.000 39.49688 ? 79  GLY A C   1 
ATOM   630  O O   . GLY A 1 79  ? 37.44700 -48.01100 -21.21700 1.000 41.88985 ? 79  GLY A O   1 
ATOM   631  N N   . HIS A 1 80  ? 38.32300 -47.59200 -23.24900 1.000 33.12460 ? 80  HIS A N   1 
ATOM   632  C CA  . HIS A 1 80  ? 38.31900 -46.15000 -23.06200 1.000 36.85031 ? 80  HIS A CA  1 
ATOM   633  C C   . HIS A 1 80  ? 38.04000 -45.47000 -24.39300 1.000 41.08983 ? 80  HIS A C   1 
ATOM   634  O O   . HIS A 1 80  ? 38.49500 -45.93000 -25.44400 1.000 37.27988 ? 80  HIS A O   1 
ATOM   635  C CB  . HIS A 1 80  ? 39.64900 -45.65200 -22.47900 1.000 36.86750 ? 80  HIS A CB  1 
ATOM   636  C CG  . HIS A 1 80  ? 40.82500 -45.85700 -23.38400 1.000 40.53859 ? 80  HIS A CG  1 
ATOM   637  N ND1 . HIS A 1 80  ? 41.66000 -46.95000 -23.28500 1.000 40.37549 ? 80  HIS A ND1 1 
ATOM   638  C CD2 . HIS A 1 80  ? 41.30800 -45.10800 -24.40400 1.000 40.62874 ? 80  HIS A CD2 1 
ATOM   639  C CE1 . HIS A 1 80  ? 42.60500 -46.86600 -24.20300 1.000 38.55401 ? 80  HIS A CE1 1 
ATOM   640  N NE2 . HIS A 1 80  ? 42.41500 -45.75700 -24.89600 1.000 39.01293 ? 80  HIS A NE2 1 
ATOM   641  N N   . SER A 1 81  ? 37.28700 -44.37500 -24.33700 1.000 38.70033 ? 81  SER A N   1 
ATOM   642  C CA  . SER A 1 81  ? 37.02300 -43.57400 -25.52000 1.000 41.50096 ? 81  SER A CA  1 
ATOM   643  C C   . SER A 1 81  ? 36.88900 -42.11900 -25.10100 1.000 44.11506 ? 81  SER A C   1 
ATOM   644  O O   . SER A 1 81  ? 36.66600 -41.80800 -23.92900 1.000 40.41574 ? 81  SER A O   1 
ATOM   645  C CB  . SER A 1 81  ? 35.76500 -44.04800 -26.25500 1.000 36.64330 ? 81  SER A CB  1 
ATOM   646  O OG  . SER A 1 81  ? 34.65100 -44.07900 -25.38600 1.000 44.57446 ? 81  SER A OG  1 
ATOM   647  N N   . MET A 1 82  ? 37.03700 -41.22700 -26.07600 1.000 39.44742 ? 82  MET A N   1 
ATOM   648  C CA  . MET A 1 82  ? 36.93400 -39.79300 -25.84300 1.000 33.54626 ? 82  MET A CA  1 
ATOM   649  C C   . MET A 1 82  ? 35.73300 -39.25000 -26.60400 1.000 37.30021 ? 82  MET A C   1 
ATOM   650  O O   . MET A 1 82  ? 35.69700 -39.30500 -27.83800 1.000 36.29348 ? 82  MET A O   1 
ATOM   651  C CB  . MET A 1 82  ? 38.21200 -39.07000 -26.26700 1.000 33.26488 ? 82  MET A CB  1 
ATOM   652  C CG  . MET A 1 82  ? 38.24600 -37.61400 -25.84100 1.000 37.69001 ? 82  MET A CG  1 
ATOM   653  S SD  . MET A 1 82  ? 39.79200 -36.79000 -26.24000 1.000 33.03019 ? 82  MET A SD  1 
ATOM   654  C CE  . MET A 1 82  ? 39.75800 -36.84300 -28.03000 1.000 36.84799 ? 82  MET A CE  1 
ATOM   655  N N   . GLN A 1 83  ? 34.75900 -38.72300 -25.86800 1.000 36.26099 ? 83  GLN A N   1 
ATOM   656  C CA  . GLN A 1 83  ? 33.58100 -38.07700 -26.44000 1.000 35.01860 ? 83  GLN A CA  1 
ATOM   657  C C   . GLN A 1 83  ? 33.64200 -36.60000 -26.06900 1.000 34.49062 ? 83  GLN A C   1 
ATOM   658  O O   . GLN A 1 83  ? 33.34900 -36.22700 -24.93100 1.000 36.06099 ? 83  GLN A O   1 
ATOM   659  C CB  . GLN A 1 83  ? 32.29700 -38.72600 -25.93400 1.000 25.90999 ? 83  GLN A CB  1 
ATOM   660  C CG  . GLN A 1 83  ? 31.02800 -38.07800 -26.46600 1.000 31.00655 ? 83  GLN A CG  1 
ATOM   661  C CD  . GLN A 1 83  ? 29.76400 -38.70000 -25.89000 1.000 37.78234 ? 83  GLN A CD  1 
ATOM   662  O OE1 . GLN A 1 83  ? 29.81700 -39.50800 -24.95600 1.000 31.93136 ? 83  GLN A OE1 1 
ATOM   663  N NE2 . GLN A 1 83  ? 28.61900 -38.32500 -26.44900 1.000 36.83724 ? 83  GLN A NE2 1 
ATOM   664  N N   . ASN A 1 84  ? 34.01800 -35.76200 -27.03500 1.000 28.58442 ? 84  ASN A N   1 
ATOM   665  C CA  . ASN A 1 84  ? 34.17900 -34.32100 -26.82200 1.000 29.71513 ? 84  ASN A CA  1 
ATOM   666  C C   . ASN A 1 84  ? 35.20700 -34.13700 -25.71100 1.000 33.18110 ? 84  ASN A C   1 
ATOM   667  O O   . ASN A 1 84  ? 36.34500 -34.61600 -25.86300 1.000 35.02061 ? 84  ASN A O   1 
ATOM   668  C CB  . ASN A 1 84  ? 32.80600 -33.69200 -26.57400 1.000 29.85924 ? 84  ASN A CB  1 
ATOM   669  C CG  . ASN A 1 84  ? 31.81300 -34.00500 -27.67400 1.000 33.85085 ? 84  ASN A CG  1 
ATOM   670  O OD1 . ASN A 1 84  ? 32.12100 -33.88600 -28.86100 1.000 29.40096 ? 84  ASN A OD1 1 
ATOM   671  N ND2 . ASN A 1 84  ? 30.61000 -34.41500 -27.28200 1.000 39.22964 ? 84  ASN A ND2 1 
ATOM   672  N N   . CYS A 1 85  ? 34.87500 -33.49600 -24.59000 1.000 25.95830 ? 85  CYS A N   1 
ATOM   673  C CA  . CYS A 1 85  ? 35.85100 -33.22500 -23.54300 1.000 27.74295 ? 85  CYS A CA  1 
ATOM   674  C C   . CYS A 1 85  ? 35.72100 -34.16800 -22.34700 1.000 27.61823 ? 85  CYS A C   1 
ATOM   675  O O   . CYS A 1 85  ? 36.23400 -33.86000 -21.26600 1.000 29.65079 ? 85  CYS A O   1 
ATOM   676  C CB  . CYS A 1 85  ? 35.74100 -31.77000 -23.09100 1.000 26.27254 ? 85  CYS A CB  1 
ATOM   677  S SG  . CYS A 1 85  ? 35.84800 -30.58100 -24.44800 1.000 30.37469 ? 85  CYS A SG  1 
ATOM   678  N N   . VAL A 1 86  ? 35.06100 -35.31400 -22.51600 1.000 27.50563 ? 86  VAL A N   1 
ATOM   679  C CA  . VAL A 1 86  ? 34.89700 -36.28500 -21.44300 1.000 27.09103 ? 86  VAL A CA  1 
ATOM   680  C C   . VAL A 1 86  ? 35.43400 -37.63200 -21.91100 1.000 35.79052 ? 86  VAL A C   1 
ATOM   681  O O   . VAL A 1 86  ? 35.39000 -37.96100 -23.10100 1.000 32.71744 ? 86  VAL A O   1 
ATOM   682  C CB  . VAL A 1 86  ? 33.41600 -36.39500 -20.99300 1.000 35.12919 ? 86  VAL A CB  1 
ATOM   683  C CG1 . VAL A 1 86  ? 32.55600 -37.03400 -22.07200 1.000 35.70121 ? 86  VAL A CG1 1 
ATOM   684  C CG2 . VAL A 1 86  ? 33.29100 -37.16900 -19.69500 1.000 38.78728 ? 86  VAL A CG2 1 
ATOM   685  N N   . LEU A 1 87  ? 35.97600 -38.39800 -20.96700 1.000 33.23630 ? 87  LEU A N   1 
ATOM   686  C CA  . LEU A 1 87  ? 36.39900 -39.76900 -21.21900 1.000 37.69175 ? 87  LEU A CA  1 
ATOM   687  C C   . LEU A 1 87  ? 35.33800 -40.73200 -20.70700 1.000 35.13443 ? 87  LEU A C   1 
ATOM   688  O O   . LEU A 1 87  ? 34.73900 -40.50700 -19.65200 1.000 33.78032 ? 87  LEU A O   1 
ATOM   689  C CB  . LEU A 1 87  ? 37.73700 -40.08000 -20.54500 1.000 38.23706 ? 87  LEU A CB  1 
ATOM   690  C CG  . LEU A 1 87  ? 38.98400 -39.34700 -21.03800 1.000 36.83342 ? 87  LEU A CG  1 
ATOM   691  C CD1 . LEU A 1 87  ? 40.22400 -39.88700 -20.34300 1.000 38.08605 ? 87  LEU A CD1 1 
ATOM   692  C CD2 . LEU A 1 87  ? 39.11600 -39.46300 -22.54500 1.000 40.72981 ? 87  LEU A CD2 1 
ATOM   693  N N   . LYS A 1 88  ? 35.10800 -41.80000 -21.46000 1.000 37.85272 ? 88  LYS A N   1 
ATOM   694  C CA  . LYS A 1 88  ? 34.17700 -42.85600 -21.07700 1.000 38.07451 ? 88  LYS A CA  1 
ATOM   695  C C   . LYS A 1 88  ? 35.00000 -44.11600 -20.82700 1.000 39.99180 ? 88  LYS A C   1 
ATOM   696  O O   . LYS A 1 88  ? 35.43000 -44.79000 -21.76900 1.000 45.21860 ? 88  LYS A O   1 
ATOM   697  C CB  . LYS A 1 88  ? 33.10800 -43.06100 -22.14900 1.000 32.63576 ? 88  LYS A CB  1 
ATOM   698  C CG  . LYS A 1 88  ? 32.15800 -41.87100 -22.28300 1.000 31.94872 ? 88  LYS A CG  1 
ATOM   699  C CD  . LYS A 1 88  ? 30.95600 -42.18300 -23.15200 1.000 29.40737 ? 88  LYS A CD  1 
ATOM   700  C CE  . LYS A 1 88  ? 31.36200 -42.44700 -24.59100 1.000 39.37515 ? 88  LYS A CE  1 
ATOM   701  N NZ  . LYS A 1 88  ? 30.17700 -42.73800 -25.44500 1.000 33.29498 ? 88  LYS A NZ  1 
ATOM   702  N N   . LEU A 1 89  ? 35.23200 -44.41700 -19.55200 1.000 35.63879 ? 89  LEU A N   1 
ATOM   703  C CA  . LEU A 1 89  ? 36.01900 -45.57600 -19.14900 1.000 37.37614 ? 89  LEU A CA  1 
ATOM   704  C C   . LEU A 1 89  ? 35.07400 -46.74900 -18.92900 1.000 37.10944 ? 89  LEU A C   1 
ATOM   705  O O   . LEU A 1 89  ? 34.26200 -46.73300 -17.99800 1.000 38.18258 ? 89  LEU A O   1 
ATOM   706  C CB  . LEU A 1 89  ? 36.81500 -45.27500 -17.88300 1.000 30.70461 ? 89  LEU A CB  1 
ATOM   707  C CG  . LEU A 1 89  ? 37.63800 -43.99000 -17.90600 1.000 35.35053 ? 89  LEU A CG  1 
ATOM   708  C CD1 . LEU A 1 89  ? 38.22700 -43.71300 -16.52800 1.000 35.42666 ? 89  LEU A CD1 1 
ATOM   709  C CD2 . LEU A 1 89  ? 38.72900 -44.07900 -18.95800 1.000 33.28643 ? 89  LEU A CD2 1 
ATOM   710  N N   . LYS A 1 90  ? 35.17500 -47.76100 -19.78600 1.000 37.92652 ? 90  LYS A N   1 
ATOM   711  C CA  . LYS A 1 90  ? 34.37200 -48.96400 -19.63300 1.000 34.39738 ? 90  LYS A CA  1 
ATOM   712  C C   . LYS A 1 90  ? 34.99700 -49.86100 -18.57300 1.000 39.06987 ? 90  LYS A C   1 
ATOM   713  O O   . LYS A 1 90  ? 36.19700 -50.15200 -18.62100 1.000 40.44294 ? 90  LYS A O   1 
ATOM   714  C CB  . LYS A 1 90  ? 34.26100 -49.70300 -20.96600 1.000 39.70941 ? 90  LYS A CB  1 
ATOM   715  C CG  . LYS A 1 90  ? 33.52200 -51.03400 -20.89200 1.000 38.41892 ? 90  LYS A CG  1 
ATOM   716  C CD  . LYS A 1 90  ? 32.13300 -50.93900 -21.49300 1.000 46.66994 ? 90  LYS A CD  1 
ATOM   717  C CE  . LYS A 1 90  ? 31.42200 -52.28600 -21.45100 1.000 48.94661 ? 90  LYS A CE  1 
ATOM   718  N NZ  . LYS A 1 90  ? 32.16400 -53.34800 -22.19000 1.000 48.02650 ? 90  LYS A NZ  1 
ATOM   719  N N   . VAL A 1 91  ? 34.18700 -50.28800 -17.60800 1.000 36.86455 ? 91  VAL A N   1 
ATOM   720  C CA  . VAL A 1 91  ? 34.64500 -51.14500 -16.52500 1.000 38.05711 ? 91  VAL A CA  1 
ATOM   721  C C   . VAL A 1 91  ? 33.87700 -52.45900 -16.58100 1.000 45.12738 ? 91  VAL A C   1 
ATOM   722  O O   . VAL A 1 91  ? 32.83100 -52.57300 -17.22600 1.000 39.53452 ? 91  VAL A O   1 
ATOM   723  C CB  . VAL A 1 91  ? 34.48500 -50.47600 -15.14600 1.000 38.54468 ? 91  VAL A CB  1 
ATOM   724  C CG1 . VAL A 1 91  ? 35.37400 -49.24500 -15.05000 1.000 39.23337 ? 91  VAL A CG1 1 
ATOM   725  C CG2 . VAL A 1 91  ? 33.03600 -50.10400 -14.90800 1.000 39.44794 ? 91  VAL A CG2 1 
ATOM   726  N N   . ASP A 1 92  ? 34.41800 -53.46500 -15.89100 1.000 45.10381 ? 92  ASP A N   1 
ATOM   727  C CA  . ASP A 1 92  ? 33.82100 -54.79400 -15.88500 1.000 43.03879 ? 92  ASP A CA  1 
ATOM   728  C C   . ASP A 1 92  ? 32.72200 -54.95000 -14.84600 1.000 43.73557 ? 92  ASP A C   1 
ATOM   729  O O   . ASP A 1 92  ? 32.02500 -55.97000 -14.85500 1.000 47.76254 ? 92  ASP A O   1 
ATOM   730  C CB  . ASP A 1 92  ? 34.89900 -55.85900 -15.64500 1.000 51.60529 ? 92  ASP A CB  1 
ATOM   731  C CG  . ASP A 1 92  ? 35.59100 -55.70600 -14.30100 1.000 46.86968 ? 92  ASP A CG  1 
ATOM   732  O OD1 . ASP A 1 92  ? 35.38000 -54.67900 -13.62000 1.000 51.47351 ? 92  ASP A OD1 1 
ATOM   733  O OD2 . ASP A 1 92  ? 36.35400 -56.61900 -13.92400 1.000 50.60147 ? 92  ASP A OD2 1 
ATOM   734  N N   . THR A 1 93  ? 32.55000 -53.97500 -13.95900 1.000 49.06685 ? 93  THR A N   1 
ATOM   735  C CA  . THR A 1 93  ? 31.58100 -54.05200 -12.87500 1.000 45.91826 ? 93  THR A CA  1 
ATOM   736  C C   . THR A 1 93  ? 30.54700 -52.95200 -13.05500 1.000 47.34094 ? 93  THR A C   1 
ATOM   737  O O   . THR A 1 93  ? 30.89800 -51.76900 -13.11300 1.000 47.17566 ? 93  THR A O   1 
ATOM   738  C CB  . THR A 1 93  ? 32.27300 -53.92000 -11.51700 1.000 46.12128 ? 93  THR A CB  1 
ATOM   739  O OG1 . THR A 1 93  ? 33.30100 -54.91300 -11.40600 1.000 54.37822 ? 93  THR A OG1 1 
ATOM   740  C CG2 . THR A 1 93  ? 31.27300 -54.10800 -10.38700 1.000 44.64667 ? 93  THR A CG2 1 
ATOM   741  N N   . ALA A 1 94  ? 29.27900 -53.34000 -13.15200 1.000 48.04855 ? 94  ALA A N   1 
ATOM   742  C CA  . ALA A 1 94  ? 28.19400 -52.37100 -13.16200 1.000 37.93044 ? 94  ALA A CA  1 
ATOM   743  C C   . ALA A 1 94  ? 27.96500 -51.84700 -11.75300 1.000 41.57234 ? 94  ALA A C   1 
ATOM   744  O O   . ALA A 1 94  ? 27.96300 -52.61400 -10.78500 1.000 43.26233 ? 94  ALA A O   1 
ATOM   745  C CB  . ALA A 1 94  ? 26.91200 -53.00000 -13.70600 1.000 35.19612 ? 94  ALA A CB  1 
ATOM   746  N N   . ASN A 1 95  ? 27.78900 -50.53700 -11.63900 1.000 43.57927 ? 95  ASN A N   1 
ATOM   747  C CA  . ASN A 1 95  ? 27.55400 -49.91700 -10.33900 1.000 42.39333 ? 95  ASN A CA  1 
ATOM   748  C C   . ASN A 1 95  ? 26.22600 -50.40500 -9.77300  1.000 39.52748 ? 95  ASN A C   1 
ATOM   749  O O   . ASN A 1 95  ? 25.17400 -50.14300 -10.37200 1.000 40.39206 ? 95  ASN A O   1 
ATOM   750  C CB  . ASN A 1 95  ? 27.56600 -48.39400 -10.47400 1.000 42.75732 ? 95  ASN A CB  1 
ATOM   751  C CG  . ASN A 1 95  ? 27.39400 -47.67200 -9.13900  1.000 46.19961 ? 95  ASN A CG  1 
ATOM   752  O OD1 . ASN A 1 95  ? 27.38200 -48.28700 -8.07100  1.000 39.70939 ? 95  ASN A OD1 1 
ATOM   753  N ND2 . ASN A 1 95  ? 27.26900 -46.35000 -9.20200  1.000 43.99050 ? 95  ASN A ND2 1 
ATOM   754  N N   . PRO A 1 96  ? 26.22100 -51.12300 -8.64600  1.000 37.37761 ? 96  PRO A N   1 
ATOM   755  C CA  . PRO A 1 96  ? 24.94600 -51.58300 -8.08000  1.000 41.00895 ? 96  PRO A CA  1 
ATOM   756  C C   . PRO A 1 96  ? 24.07500 -50.45500 -7.56000  1.000 43.73955 ? 96  PRO A C   1 
ATOM   757  O O   . PRO A 1 96  ? 22.85600 -50.63600 -7.45100  1.000 38.81970 ? 96  PRO A O   1 
ATOM   758  C CB  . PRO A 1 96  ? 25.38400 -52.51900 -6.94600  1.000 39.04020 ? 96  PRO A CB  1 
ATOM   759  C CG  . PRO A 1 96  ? 26.72700 -52.01800 -6.55300  1.000 33.90853 ? 96  PRO A CG  1 
ATOM   760  C CD  . PRO A 1 96  ? 27.37200 -51.53100 -7.82100  1.000 37.80681 ? 96  PRO A CD  1 
ATOM   761  N N   . LYS A 1 97  ? 24.65300 -49.29800 -7.24300  1.000 44.60654 ? 97  LYS A N   1 
ATOM   762  C CA  . LYS A 1 97  ? 23.89100 -48.15500 -6.76500  1.000 41.42724 ? 97  LYS A CA  1 
ATOM   763  C C   . LYS A 1 97  ? 23.48200 -47.21400 -7.89300  1.000 41.71277 ? 97  LYS A C   1 
ATOM   764  O O   . LYS A 1 97  ? 23.17300 -46.04700 -7.63000  1.000 49.14868 ? 97  LYS A O   1 
ATOM   765  C CB  . LYS A 1 97  ? 24.69000 -47.39400 -5.70400  1.000 37.48176 ? 97  LYS A CB  1 
ATOM   766  C CG  . LYS A 1 97  ? 25.48500 -48.29800 -4.77100  1.000 41.05572 ? 97  LYS A CG  1 
ATOM   767  C CD  . LYS A 1 97  ? 25.44400 -47.80800 -3.32900  1.000 47.98293 ? 97  LYS A CD  1 
ATOM   768  C CE  . LYS A 1 97  ? 24.04100 -47.93300 -2.74400  1.000 59.94928 ? 97  LYS A CE  1 
ATOM   769  N NZ  . LYS A 1 97  ? 23.98800 -47.53500 -1.30600  1.000 60.22726 ? 97  LYS A NZ  1 
ATOM   770  N N   . THR A 1 98  ? 23.47500 -47.69400 -9.13100  1.000 40.73930 ? 98  THR A N   1 
ATOM   771  C CA  . THR A 1 98  ? 23.07300 -46.86900 -10.26800 1.000 38.63098 ? 98  THR A CA  1 
ATOM   772  C C   . THR A 1 98  ? 21.60100 -46.49500 -10.14800 1.000 38.93156 ? 98  THR A C   1 
ATOM   773  O O   . THR A 1 98  ? 20.74500 -47.38900 -10.13100 1.000 40.54085 ? 98  THR A O   1 
ATOM   774  C CB  . THR A 1 98  ? 23.30700 -47.60500 -11.58700 1.000 40.39080 ? 98  THR A CB  1 
ATOM   775  O OG1 . THR A 1 98  ? 24.68400 -47.98100 -11.70100 1.000 43.71636 ? 98  THR A OG1 1 
ATOM   776  C CG2 . THR A 1 98  ? 22.92700 -46.71600 -12.76500 1.000 32.64397 ? 98  THR A CG2 1 
ATOM   777  N N   . PRO A 1 99  ? 21.26000 -45.21600 -10.06900 1.000 42.09379 ? 99  PRO A N   1 
ATOM   778  C CA  . PRO A 1 99  ? 19.85400 -44.81500 -10.04400 1.000 40.47637 ? 99  PRO A CA  1 
ATOM   779  C C   . PRO A 1 99  ? 19.30200 -44.67600 -11.45700 1.000 43.26691 ? 99  PRO A C   1 
ATOM   780  O O   . PRO A 1 99  ? 20.03700 -44.69800 -12.44700 1.000 46.59372 ? 99  PRO A O   1 
ATOM   781  C CB  . PRO A 1 99  ? 19.90300 -43.45400 -9.34400  1.000 43.43171 ? 99  PRO A CB  1 
ATOM   782  C CG  . PRO A 1 99  ? 21.21400 -42.88400 -9.79200  1.000 41.60695 ? 99  PRO A CG  1 
ATOM   783  C CD  . PRO A 1 99  ? 22.16300 -44.05900 -9.92600  1.000 40.81392 ? 99  PRO A CD  1 
ATOM   784  N N   . LYS A 1 100 ? 17.98100 -44.54600 -11.52900 1.000 39.04885 ? 100 LYS A N   1 
ATOM   785  C CA  . LYS A 1 100 ? 17.34600 -44.12200 -12.76800 1.000 44.14004 ? 100 LYS A CA  1 
ATOM   786  C C   . LYS A 1 100 ? 17.91800 -42.76900 -13.17200 1.000 42.67434 ? 100 LYS A C   1 
ATOM   787  O O   . LYS A 1 100 ? 17.85200 -41.80600 -12.40200 1.000 41.71233 ? 100 LYS A O   1 
ATOM   788  C CB  . LYS A 1 100 ? 15.83000 -44.04500 -12.57900 1.000 47.58998 ? 100 LYS A CB  1 
ATOM   789  C CG  . LYS A 1 100 ? 15.06200 -43.39400 -13.72600 1.000 56.09972 ? 100 LYS A CG  1 
ATOM   790  C CD  . LYS A 1 100 ? 14.81400 -44.35600 -14.88100 1.000 62.10663 ? 100 LYS A CD  1 
ATOM   791  C CE  . LYS A 1 100 ? 13.87400 -43.74100 -15.91600 1.000 61.75997 ? 100 LYS A CE  1 
ATOM   792  N NZ  . LYS A 1 100 ? 14.39200 -42.44900 -16.45900 1.000 52.67137 ? 100 LYS A NZ  1 
ATOM   793  N N   . TYR A 1 101 ? 18.51200 -42.70100 -14.36100 1.000 37.79759 ? 101 TYR A N   1 
ATOM   794  C CA  . TYR A 1 101 ? 19.21100 -41.49500 -14.77400 1.000 37.47270 ? 101 TYR A CA  1 
ATOM   795  C C   . TYR A 1 101 ? 19.04000 -41.26100 -16.26700 1.000 36.00992 ? 101 TYR A C   1 
ATOM   796  O O   . TYR A 1 101 ? 18.71400 -42.17000 -17.03300 1.000 36.33435 ? 101 TYR A O   1 
ATOM   797  C CB  . TYR A 1 101 ? 20.71000 -41.56300 -14.44100 1.000 36.52079 ? 101 TYR A CB  1 
ATOM   798  C CG  . TYR A 1 101 ? 21.49900 -42.48000 -15.35400 1.000 35.74272 ? 101 TYR A CG  1 
ATOM   799  C CD1 . TYR A 1 101 ? 21.59800 -43.83700 -15.08600 1.000 37.13523 ? 101 TYR A CD1 1 
ATOM   800  C CD2 . TYR A 1 101 ? 22.14500 -41.98600 -16.48300 1.000 33.19899 ? 101 TYR A CD2 1 
ATOM   801  C CE1 . TYR A 1 101 ? 22.31300 -44.67900 -15.91300 1.000 38.71090 ? 101 TYR A CE1 1 
ATOM   802  C CE2 . TYR A 1 101 ? 22.85900 -42.82100 -17.31700 1.000 38.76939 ? 101 TYR A CE2 1 
ATOM   803  C CZ  . TYR A 1 101 ? 22.94000 -44.16700 -17.02600 1.000 37.79894 ? 101 TYR A CZ  1 
ATOM   804  O OH  . TYR A 1 101 ? 23.65000 -45.00400 -17.85200 1.000 43.11826 ? 101 TYR A OH  1 
ATOM   805  N N   . LYS A 1 102 ? 19.28200 -40.01700 -16.66600 1.000 39.47171 ? 102 LYS A N   1 
ATOM   806  C CA  . LYS A 1 102 ? 19.43500 -39.66300 -18.06800 1.000 39.74493 ? 102 LYS A CA  1 
ATOM   807  C C   . LYS A 1 102 ? 20.28800 -38.40600 -18.14500 1.000 37.44890 ? 102 LYS A C   1 
ATOM   808  O O   . LYS A 1 102 ? 20.47800 -37.69800 -17.15200 1.000 30.59168 ? 102 LYS A O   1 
ATOM   809  C CB  . LYS A 1 102 ? 18.08100 -39.46100 -18.75900 1.000 40.25543 ? 102 LYS A CB  1 
ATOM   810  C CG  . LYS A 1 102 ? 17.16900 -38.43800 -18.10300 1.000 37.38622 ? 102 LYS A CG  1 
ATOM   811  C CD  . LYS A 1 102 ? 15.73100 -38.61100 -18.59400 1.000 51.45357 ? 102 LYS A CD  1 
ATOM   812  C CE  . LYS A 1 102 ? 14.79100 -37.55400 -18.02100 1.000 43.60192 ? 102 LYS A CE  1 
ATOM   813  N NZ  . LYS A 1 102 ? 14.62600 -36.38700 -18.93200 1.000 47.65535 ? 102 LYS A NZ  1 
ATOM   814  N N   . PHE A 1 103 ? 20.81500 -38.15000 -19.33400 1.000 36.18433 ? 103 PHE A N   1 
ATOM   815  C CA  . PHE A 1 103 ? 21.64300 -36.98200 -19.57700 1.000 29.40058 ? 103 PHE A CA  1 
ATOM   816  C C   . PHE A 1 103 ? 20.79800 -35.88300 -20.20300 1.000 36.58246 ? 103 PHE A C   1 
ATOM   817  O O   . PHE A 1 103 ? 19.98300 -36.14000 -21.09600 1.000 38.87106 ? 103 PHE A O   1 
ATOM   818  C CB  . PHE A 1 103 ? 22.82900 -37.32700 -20.47900 1.000 29.90379 ? 103 PHE A CB  1 
ATOM   819  C CG  . PHE A 1 103 ? 23.82200 -38.26400 -19.84400 1.000 33.48538 ? 103 PHE A CG  1 
ATOM   820  C CD1 . PHE A 1 103 ? 23.87100 -38.41500 -18.46500 1.000 24.10626 ? 103 PHE A CD1 1 
ATOM   821  C CD2 . PHE A 1 103 ? 24.71000 -38.99100 -20.62700 1.000 28.85602 ? 103 PHE A CD2 1 
ATOM   822  C CE1 . PHE A 1 103 ? 24.78300 -39.27200 -17.87800 1.000 23.45567 ? 103 PHE A CE1 1 
ATOM   823  C CE2 . PHE A 1 103 ? 25.62300 -39.84900 -20.04900 1.000 26.36747 ? 103 PHE A CE2 1 
ATOM   824  C CZ  . PHE A 1 103 ? 25.66100 -39.99200 -18.67100 1.000 31.40942 ? 103 PHE A CZ  1 
ATOM   825  N N   . VAL A 1 104 ? 20.98900 -34.66000 -19.72000 1.000 31.01685 ? 104 VAL A N   1 
ATOM   826  C CA  . VAL A 1 104 ? 20.21000 -33.51100 -20.15800 1.000 34.90424 ? 104 VAL A CA  1 
ATOM   827  C C   . VAL A 1 104 ? 21.15600 -32.33600 -20.34800 1.000 36.59639 ? 104 VAL A C   1 
ATOM   828  O O   . VAL A 1 104 ? 21.99600 -32.06300 -19.48400 1.000 33.66097 ? 104 VAL A O   1 
ATOM   829  C CB  . VAL A 1 104 ? 19.09900 -33.15900 -19.14700 1.000 38.67020 ? 104 VAL A CB  1 
ATOM   830  C CG1 . VAL A 1 104 ? 18.58500 -31.74200 -19.37200 1.000 36.28411 ? 104 VAL A CG1 1 
ATOM   831  C CG2 . VAL A 1 104 ? 17.95500 -34.16100 -19.24700 1.000 37.69913 ? 104 VAL A CG2 1 
ATOM   832  N N   . ARG A 1 105 ? 21.03700 -31.65500 -21.48100 1.000 31.27308 ? 105 ARG A N   1 
ATOM   833  C CA  . ARG A 1 105 ? 21.73100 -30.39300 -21.68600 1.000 31.46074 ? 105 ARG A CA  1 
ATOM   834  C C   . ARG A 1 105 ? 20.83100 -29.28600 -21.15900 1.000 36.14846 ? 105 ARG A C   1 
ATOM   835  O O   . ARG A 1 105 ? 19.81300 -28.95700 -21.77500 1.000 38.96794 ? 105 ARG A O   1 
ATOM   836  C CB  . ARG A 1 105 ? 22.08000 -30.17300 -23.15400 1.000 30.23794 ? 105 ARG A CB  1 
ATOM   837  C CG  . ARG A 1 105 ? 22.89100 -28.90700 -23.37700 1.000 34.94740 ? 105 ARG A CG  1 
ATOM   838  C CD  . ARG A 1 105 ? 23.56600 -28.90200 -24.73500 1.000 35.05518 ? 105 ARG A CD  1 
ATOM   839  N NE  . ARG A 1 105 ? 24.37300 -27.70500 -24.92200 1.000 33.88268 ? 105 ARG A NE  1 
ATOM   840  C CZ  . ARG A 1 105 ? 25.62600 -27.57600 -24.50900 1.000 31.68373 ? 105 ARG A CZ  1 
ATOM   841  N NH1 . ARG A 1 105 ? 26.24600 -28.55400 -23.87000 1.000 32.24746 ? 105 ARG A NH1 1 
ATOM   842  N NH2 . ARG A 1 105 ? 26.27200 -26.43700 -24.74200 1.000 28.18187 ? 105 ARG A NH2 1 
ATOM   843  N N   . ILE A 1 106 ? 21.20500 -28.72200 -20.01100 1.000 39.42082 ? 106 ILE A N   1 
ATOM   844  C CA  . ILE A 1 106 ? 20.38800 -27.70000 -19.38200 1.000 30.88382 ? 106 ILE A CA  1 
ATOM   845  C C   . ILE A 1 106 ? 20.36800 -26.44000 -20.24400 1.000 36.00369 ? 106 ILE A C   1 
ATOM   846  O O   . ILE A 1 106 ? 21.20900 -26.23300 -21.12800 1.000 33.42304 ? 106 ILE A O   1 
ATOM   847  C CB  . ILE A 1 106 ? 20.90500 -27.40900 -17.96300 1.000 30.33216 ? 106 ILE A CB  1 
ATOM   848  C CG1 . ILE A 1 106 ? 19.73800 -27.21100 -17.00200 1.000 37.00371 ? 106 ILE A CG1 1 
ATOM   849  C CG2 . ILE A 1 106 ? 21.84000 -26.20700 -17.95000 1.000 34.32512 ? 106 ILE A CG2 1 
ATOM   850  C CD1 . ILE A 1 106 ? 18.89200 -28.45000 -16.84000 1.000 40.67718 ? 106 ILE A CD1 1 
ATOM   851  N N   . GLN A 1 107 ? 19.37200 -25.59300 -19.99000 1.000 41.58220 ? 107 GLN A N   1 
ATOM   852  C CA  . GLN A 1 107 ? 19.21600 -24.31100 -20.65700 1.000 39.05986 ? 107 GLN A CA  1 
ATOM   853  C C   . GLN A 1 107 ? 19.71900 -23.18600 -19.76300 1.000 33.94838 ? 107 GLN A C   1 
ATOM   854  O O   . GLN A 1 107 ? 19.66900 -23.29500 -18.53500 1.000 33.04815 ? 107 GLN A O   1 
ATOM   855  C CB  . GLN A 1 107 ? 17.74600 -24.05900 -21.00900 1.000 41.27158 ? 107 GLN A CB  1 
ATOM   856  C CG  . GLN A 1 107 ? 17.19900 -24.98400 -22.07700 1.000 40.20083 ? 107 GLN A CG  1 
ATOM   857  C CD  . GLN A 1 107 ? 17.85900 -24.76400 -23.42500 1.000 52.12975 ? 107 GLN A CD  1 
ATOM   858  O OE1 . GLN A 1 107 ? 17.86000 -23.65000 -23.95500 1.000 52.24806 ? 107 GLN A OE1 1 
ATOM   859  N NE2 . GLN A 1 107 ? 18.43400 -25.82500 -23.98400 1.000 47.56769 ? 107 GLN A NE2 1 
ATOM   860  N N   . PRO A 1 108 ? 20.22000 -22.09800 -20.34500 1.000 38.95632 ? 108 PRO A N   1 
ATOM   861  C CA  . PRO A 1 108 ? 20.63200 -20.95400 -19.52200 1.000 36.39578 ? 108 PRO A CA  1 
ATOM   862  C C   . PRO A 1 108 ? 19.44600 -20.40400 -18.74700 1.000 35.98693 ? 108 PRO A C   1 
ATOM   863  O O   . PRO A 1 108 ? 18.34700 -20.24700 -19.28600 1.000 35.53211 ? 108 PRO A O   1 
ATOM   864  C CB  . PRO A 1 108 ? 21.16300 -19.94600 -20.54900 1.000 37.77547 ? 108 PRO A CB  1 
ATOM   865  C CG  . PRO A 1 108 ? 20.51900 -20.34300 -21.83700 1.000 36.22122 ? 108 PRO A CG  1 
ATOM   866  C CD  . PRO A 1 108 ? 20.40300 -21.83800 -21.78300 1.000 35.11410 ? 108 PRO A CD  1 
ATOM   867  N N   . GLY A 1 109 ? 19.67200 -20.13000 -17.46200 1.000 35.81753 ? 109 GLY A N   1 
ATOM   868  C CA  . GLY A 1 109 ? 18.64000 -19.68900 -16.55600 1.000 34.84024 ? 109 GLY A CA  1 
ATOM   869  C C   . GLY A 1 109 ? 18.10800 -20.78500 -15.65600 1.000 33.13874 ? 109 GLY A C   1 
ATOM   870  O O   . GLY A 1 109 ? 17.62500 -20.49300 -14.55600 1.000 34.90589 ? 109 GLY A O   1 
ATOM   871  N N   . GLN A 1 110 ? 18.18600 -22.03600 -16.09500 1.000 37.05997 ? 110 GLN A N   1 
ATOM   872  C CA  . GLN A 1 110 ? 17.76700 -23.14200 -15.25200 1.000 36.80396 ? 110 GLN A CA  1 
ATOM   873  C C   . GLN A 1 110 ? 18.75800 -23.35200 -14.11200 1.000 38.01139 ? 110 GLN A C   1 
ATOM   874  O O   . GLN A 1 110 ? 19.89900 -22.87600 -14.14100 1.000 36.87051 ? 110 GLN A O   1 
ATOM   875  C CB  . GLN A 1 110 ? 17.63100 -24.42300 -16.07000 1.000 38.62642 ? 110 GLN A CB  1 
ATOM   876  C CG  . GLN A 1 110 ? 16.58700 -24.34000 -17.16900 1.000 48.34250 ? 110 GLN A CG  1 
ATOM   877  C CD  . GLN A 1 110 ? 16.00400 -25.69700 -17.50500 1.000 57.27604 ? 110 GLN A CD  1 
ATOM   878  O OE1 . GLN A 1 110 ? 16.17700 -26.20600 -18.61600 1.000 60.48702 ? 110 GLN A OE1 1 
ATOM   879  N NE2 . GLN A 1 110 ? 15.30900 -26.29400 -16.54300 1.000 45.61903 ? 110 GLN A NE2 1 
ATOM   880  N N   . THR A 1 111 ? 18.30700 -24.08100 -13.09800 1.000 31.76686 ? 111 THR A N   1 
ATOM   881  C CA  . THR A 1 111 ? 19.10300 -24.34100 -11.91100 1.000 36.64106 ? 111 THR A CA  1 
ATOM   882  C C   . THR A 1 111 ? 19.33000 -25.83800 -11.75200 1.000 33.62264 ? 111 THR A C   1 
ATOM   883  O O   . THR A 1 111 ? 18.64900 -26.66300 -12.36900 1.000 33.11907 ? 111 THR A O   1 
ATOM   884  C CB  . THR A 1 111 ? 18.42800 -23.78400 -10.65200 1.000 36.79085 ? 111 THR A CB  1 
ATOM   885  O OG1 . THR A 1 111 ? 17.12800 -24.36500 -10.51400 1.000 30.71524 ? 111 THR A OG1 1 
ATOM   886  C CG2 . THR A 1 111 ? 18.30100 -22.27100 -10.73700 1.000 32.40227 ? 111 THR A CG2 1 
ATOM   887  N N   . PHE A 1 112 ? 20.30200 -26.17400 -10.90900 1.000 35.22110 ? 112 PHE A N   1 
ATOM   888  C CA  . PHE A 1 112 ? 20.63600 -27.55800 -10.60400 1.000 32.90493 ? 112 PHE A CA  1 
ATOM   889  C C   . PHE A 1 112 ? 21.53200 -27.57100 -9.37600  1.000 27.51676 ? 112 PHE A C   1 
ATOM   890  O O   . PHE A 1 112 ? 22.09800 -26.54400 -8.99300  1.000 31.79794 ? 112 PHE A O   1 
ATOM   891  C CB  . PHE A 1 112 ? 21.31700 -28.25200 -11.78900 1.000 33.28608 ? 112 PHE A CB  1 
ATOM   892  C CG  . PHE A 1 112 ? 22.56700 -27.56100 -12.27100 1.000 37.34468 ? 112 PHE A CG  1 
ATOM   893  C CD1 . PHE A 1 112 ? 22.49500 -26.53100 -13.19900 1.000 32.83530 ? 112 PHE A CD1 1 
ATOM   894  C CD2 . PHE A 1 112 ? 23.81600 -27.95500 -11.81300 1.000 33.41533 ? 112 PHE A CD2 1 
ATOM   895  C CE1 . PHE A 1 112 ? 23.64200 -25.90500 -13.65100 1.000 30.78506 ? 112 PHE A CE1 1 
ATOM   896  C CE2 . PHE A 1 112 ? 24.96500 -27.33300 -12.26200 1.000 30.62084 ? 112 PHE A CE2 1 
ATOM   897  C CZ  . PHE A 1 112 ? 24.87800 -26.30500 -13.18300 1.000 29.37530 ? 112 PHE A CZ  1 
ATOM   898  N N   . SER A 1 113 ? 21.64800 -28.74400 -8.76200  1.000 27.80790 ? 113 SER A N   1 
ATOM   899  C CA  . SER A 1 113 ? 22.47500 -28.93300 -7.57900  1.000 30.59539 ? 113 SER A CA  1 
ATOM   900  C C   . SER A 1 113 ? 23.83000 -29.50600 -7.97100  1.000 34.42426 ? 113 SER A C   1 
ATOM   901  O O   . SER A 1 113 ? 23.91900 -30.37500 -8.84400  1.000 35.63017 ? 113 SER A O   1 
ATOM   902  C CB  . SER A 1 113 ? 21.79600 -29.86600 -6.57200  1.000 29.37842 ? 113 SER A CB  1 
ATOM   903  O OG  . SER A 1 113 ? 20.58000 -29.31600 -6.09600  1.000 35.10202 ? 113 SER A OG  1 
ATOM   904  N N   . VAL A 1 114 ? 24.88100 -29.01900 -7.31800  1.000 29.19998 ? 114 VAL A N   1 
ATOM   905  C CA  . VAL A 1 114 ? 26.24300 -29.50000 -7.52100  1.000 30.47254 ? 114 VAL A CA  1 
ATOM   906  C C   . VAL A 1 114 ? 26.68200 -30.23400 -6.26000  1.000 29.52401 ? 114 VAL A C   1 
ATOM   907  O O   . VAL A 1 114 ? 26.48300 -29.74000 -5.14400  1.000 27.03122 ? 114 VAL A O   1 
ATOM   908  C CB  . VAL A 1 114 ? 27.20900 -28.34700 -7.85600  1.000 29.43388 ? 114 VAL A CB  1 
ATOM   909  C CG1 . VAL A 1 114 ? 28.65600 -28.80200 -7.74200  1.000 27.61096 ? 114 VAL A CG1 1 
ATOM   910  C CG2 . VAL A 1 114 ? 26.93500 -27.81300 -9.25200  1.000 31.96402 ? 114 VAL A CG2 1 
ATOM   911  N N   . LEU A 1 115 ? 27.26200 -31.41400 -6.43700  1.000 30.23159 ? 115 LEU A N   1 
ATOM   912  C CA  . LEU A 1 115 ? 27.86100 -32.17800 -5.34700  1.000 26.18662 ? 115 LEU A CA  1 
ATOM   913  C C   . LEU A 1 115 ? 29.37300 -32.08500 -5.52000  1.000 32.21356 ? 115 LEU A C   1 
ATOM   914  O O   . LEU A 1 115 ? 29.96500 -32.83100 -6.30700  1.000 30.66739 ? 115 LEU A O   1 
ATOM   915  C CB  . LEU A 1 115 ? 27.37400 -33.62400 -5.35600  1.000 27.89056 ? 115 LEU A CB  1 
ATOM   916  C CG  . LEU A 1 115 ? 27.99400 -34.54600 -4.30100  1.000 33.00618 ? 115 LEU A CG  1 
ATOM   917  C CD1 . LEU A 1 115 ? 27.59800 -34.11700 -2.89200  1.000 28.93960 ? 115 LEU A CD1 1 
ATOM   918  C CD2 . LEU A 1 115 ? 27.61900 -35.99900 -4.55600  1.000 30.55970 ? 115 LEU A CD2 1 
ATOM   919  N N   . ALA A 1 116 ? 29.98900 -31.15200 -4.79800  1.000 34.35454 ? 116 ALA A N   1 
ATOM   920  C CA  . ALA A 1 116 ? 31.42900 -30.96000 -4.88200  1.000 28.43757 ? 116 ALA A CA  1 
ATOM   921  C C   . ALA A 1 116 ? 32.15300 -32.14300 -4.25500  1.000 35.86712 ? 116 ALA A C   1 
ATOM   922  O O   . ALA A 1 116 ? 31.85800 -32.53400 -3.12100  1.000 36.96756 ? 116 ALA A O   1 
ATOM   923  C CB  . ALA A 1 116 ? 31.83000 -29.66100 -4.18700  1.000 34.86384 ? 116 ALA A CB  1 
ATOM   924  N N   . CYS A 1 117 ? 33.10300 -32.71600 -4.99700  1.000 33.83545 ? 117 CYS A N   1 
ATOM   925  C CA  . CYS A 1 117 ? 33.83500 -33.89400 -4.56100  1.000 34.21276 ? 117 CYS A CA  1 
ATOM   926  C C   . CYS A 1 117 ? 35.33300 -33.67100 -4.70700  1.000 39.37233 ? 117 CYS A C   1 
ATOM   927  O O   . CYS A 1 117 ? 35.78500 -32.87000 -5.53100  1.000 36.80775 ? 117 CYS A O   1 
ATOM   928  C CB  . CYS A 1 117 ? 33.42700 -35.13600 -5.36200  1.000 36.72545 ? 117 CYS A CB  1 
ATOM   929  S SG  . CYS A 1 117 ? 31.68100 -35.56800 -5.23800  1.000 38.27519 ? 117 CYS A SG  1 
ATOM   930  N N   . TYR A 1 118 ? 36.09700 -34.39200 -3.88900  1.000 42.58573 ? 118 TYR A N   1 
ATOM   931  C CA  . TYR A 1 118 ? 37.55100 -34.43100 -3.98700  1.000 41.83610 ? 118 TYR A CA  1 
ATOM   932  C C   . TYR A 1 118 ? 38.00400 -35.85300 -3.70000  1.000 42.73557 ? 118 TYR A C   1 
ATOM   933  O O   . TYR A 1 118 ? 37.60100 -36.43900 -2.69100  1.000 48.71016 ? 118 TYR A O   1 
ATOM   934  C CB  . TYR A 1 118 ? 38.21100 -33.44400 -3.01300  1.000 43.18551 ? 118 TYR A CB  1 
ATOM   935  C CG  . TYR A 1 118 ? 37.77900 -32.01200 -3.23600  1.000 45.29147 ? 118 TYR A CG  1 
ATOM   936  C CD1 . TYR A 1 118 ? 38.44800 -31.19800 -4.14300  1.000 39.13239 ? 118 TYR A CD1 1 
ATOM   937  C CD2 . TYR A 1 118 ? 36.69000 -31.47900 -2.55500  1.000 41.71752 ? 118 TYR A CD2 1 
ATOM   938  C CE1 . TYR A 1 118 ? 38.05200 -29.89200 -4.35700  1.000 37.56110 ? 118 TYR A CE1 1 
ATOM   939  C CE2 . TYR A 1 118 ? 36.28400 -30.17400 -2.76400  1.000 39.62020 ? 118 TYR A CE2 1 
ATOM   940  C CZ  . TYR A 1 118 ? 36.97000 -29.38500 -3.66600  1.000 40.36066 ? 118 TYR A CZ  1 
ATOM   941  O OH  . TYR A 1 118 ? 36.56900 -28.08600 -3.87800  1.000 43.50013 ? 118 TYR A OH  1 
ATOM   942  N N   . ASN A 1 119 ? 38.82800 -36.40400 -4.59500  1.000 39.18724 ? 119 ASN A N   1 
ATOM   943  C CA  . ASN A 1 119 ? 39.31700 -37.78000 -4.48400  1.000 44.46113 ? 119 ASN A CA  1 
ATOM   944  C C   . ASN A 1 119 ? 38.16300 -38.78000 -4.44600  1.000 44.66828 ? 119 ASN A C   1 
ATOM   945  O O   . ASN A 1 119 ? 38.20800 -39.78100 -3.72700  1.000 44.94579 ? 119 ASN A O   1 
ATOM   946  C CB  . ASN A 1 119 ? 40.22300 -37.95400 -3.26200  1.000 42.59346 ? 119 ASN A CB  1 
ATOM   947  C CG  . ASN A 1 119 ? 41.45900 -37.08800 -3.32800  1.000 48.70926 ? 119 ASN A CG  1 
ATOM   948  O OD1 . ASN A 1 119 ? 42.38500 -37.36300 -4.09300  1.000 53.42672 ? 119 ASN A OD1 1 
ATOM   949  N ND2 . ASN A 1 119 ? 41.48400 -36.03300 -2.52400  1.000 48.36924 ? 119 ASN A ND2 1 
ATOM   950  N N   . GLY A 1 120 ? 37.11700 -38.50600 -5.22200  1.000 40.86815 ? 120 GLY A N   1 
ATOM   951  C CA  . GLY A 1 120 ? 35.97100 -39.38700 -5.29800  1.000 43.55032 ? 120 GLY A CA  1 
ATOM   952  C C   . GLY A 1 120 ? 35.05700 -39.37900 -4.09300  1.000 45.13937 ? 120 GLY A C   1 
ATOM   953  O O   . GLY A 1 120 ? 34.09600 -40.15900 -4.06600  1.000 41.45515 ? 120 GLY A O   1 
ATOM   954  N N   . SER A 1 121 ? 35.31700 -38.53200 -3.09400  1.000 42.01623 ? 121 SER A N   1 
ATOM   955  C CA  . SER A 1 121 ? 34.48500 -38.47300 -1.90100  1.000 47.71062 ? 121 SER A CA  1 
ATOM   956  C C   . SER A 1 121 ? 33.71600 -37.16200 -1.85800  1.000 48.91606 ? 121 SER A C   1 
ATOM   957  O O   . SER A 1 121 ? 34.29800 -36.10000 -2.11900  1.000 44.70048 ? 121 SER A O   1 
ATOM   958  C CB  . SER A 1 121 ? 35.33900 -38.61700 -0.63600  1.000 46.90367 ? 121 SER A CB  1 
ATOM   959  O OG  . SER A 1 121 ? 35.96000 -39.89100 -0.58200  1.000 53.67767 ? 121 SER A OG  1 
ATOM   960  N N   . PRO A 1 122 ? 32.42200 -37.19100 -1.54400  1.000 46.56996 ? 122 PRO A N   1 
ATOM   961  C CA  . PRO A 1 122 ? 31.65200 -35.94400 -1.49500  1.000 42.81041 ? 122 PRO A CA  1 
ATOM   962  C C   . PRO A 1 122 ? 32.12900 -35.03300 -0.37600  1.000 43.41306 ? 122 PRO A C   1 
ATOM   963  O O   . PRO A 1 122 ? 32.47700 -35.48400 0.71700   1.000 48.92296 ? 122 PRO A O   1 
ATOM   964  C CB  . PRO A 1 122 ? 30.21500 -36.42200 -1.25300  1.000 41.88593 ? 122 PRO A CB  1 
ATOM   965  C CG  . PRO A 1 122 ? 30.19900 -37.83500 -1.73900  1.000 48.81341 ? 122 PRO A CG  1 
ATOM   966  C CD  . PRO A 1 122 ? 31.56000 -38.37600 -1.40400  1.000 51.53198 ? 122 PRO A CD  1 
ATOM   967  N N   . SER A 1 123 ? 32.14300 -33.73600 -0.66500  1.000 45.15301 ? 123 SER A N   1 
ATOM   968  C CA  . SER A 1 123 ? 32.51200 -32.71900 0.30700   1.000 40.78390 ? 123 SER A CA  1 
ATOM   969  C C   . SER A 1 123 ? 31.35700 -31.81400 0.69800   1.000 41.81719 ? 123 SER A C   1 
ATOM   970  O O   . SER A 1 123 ? 31.35900 -31.27500 1.80700   1.000 47.87041 ? 123 SER A O   1 
ATOM   971  C CB  . SER A 1 123 ? 33.65900 -31.85900 -0.24100  1.000 40.18040 ? 123 SER A CB  1 
ATOM   972  O OG  . SER A 1 123 ? 33.93000 -30.76000 0.61000   1.000 48.54399 ? 123 SER A OG  1 
ATOM   973  N N   . GLY A 1 124 ? 30.37400 -31.64300 -0.17600  1.000 37.46553 ? 124 GLY A N   1 
ATOM   974  C CA  . GLY A 1 124 ? 29.26800 -30.74600 0.10000   1.000 36.12209 ? 124 GLY A CA  1 
ATOM   975  C C   . GLY A 1 124 ? 28.37000 -30.65000 -1.11200  1.000 36.55522 ? 124 GLY A C   1 
ATOM   976  O O   . GLY A 1 124 ? 28.71800 -31.09300 -2.21100  1.000 39.31530 ? 124 GLY A O   1 
ATOM   977  N N   . VAL A 1 125 ? 27.20000 -30.05500 -0.89400  1.000 32.42667 ? 125 VAL A N   1 
ATOM   978  C CA  . VAL A 1 125 ? 26.17800 -29.93300 -1.92600  1.000 33.54220 ? 125 VAL A CA  1 
ATOM   979  C C   . VAL A 1 125 ? 25.58900 -28.53000 -1.85800  1.000 33.58943 ? 125 VAL A C   1 
ATOM   980  O O   . VAL A 1 125 ? 25.31200 -28.02100 -0.76700  1.000 32.49208 ? 125 VAL A O   1 
ATOM   981  C CB  . VAL A 1 125 ? 25.08300 -31.01100 -1.76500  1.000 34.55498 ? 125 VAL A CB  1 
ATOM   982  C CG1 . VAL A 1 125 ? 24.53300 -31.01600 -0.34400  1.000 39.26335 ? 125 VAL A CG1 1 
ATOM   983  C CG2 . VAL A 1 125 ? 23.96400 -30.81300 -2.78100  1.000 27.01368 ? 125 VAL A CG2 1 
ATOM   984  N N   . TYR A 1 126 ? 25.42000 -27.89600 -3.02000  1.000 27.54434 ? 126 TYR A N   1 
ATOM   985  C CA  . TYR A 1 126 ? 24.87200 -26.54900 -3.08400  1.000 27.50315 ? 126 TYR A CA  1 
ATOM   986  C C   . TYR A 1 126 ? 24.14200 -26.35700 -4.40600  1.000 28.72383 ? 126 TYR A C   1 
ATOM   987  O O   . TYR A 1 126 ? 24.38800 -27.06300 -5.38600  1.000 26.87520 ? 126 TYR A O   1 
ATOM   988  C CB  . TYR A 1 126 ? 25.96300 -25.48000 -2.91500  1.000 31.23320 ? 126 TYR A CB  1 
ATOM   989  C CG  . TYR A 1 126 ? 27.14700 -25.62300 -3.85000  1.000 34.25115 ? 126 TYR A CG  1 
ATOM   990  C CD1 . TYR A 1 126 ? 27.11900 -25.08500 -5.12900  1.000 35.66799 ? 126 TYR A CD1 1 
ATOM   991  C CD2 . TYR A 1 126 ? 28.29900 -26.28000 -3.44600  1.000 32.09867 ? 126 TYR A CD2 1 
ATOM   992  C CE1 . TYR A 1 126 ? 28.20000 -25.21000 -5.98100  1.000 30.33939 ? 126 TYR A CE1 1 
ATOM   993  C CE2 . TYR A 1 126 ? 29.38400 -26.40700 -4.29400  1.000 36.30191 ? 126 TYR A CE2 1 
ATOM   994  C CZ  . TYR A 1 126 ? 29.32600 -25.87000 -5.56100  1.000 36.12771 ? 126 TYR A CZ  1 
ATOM   995  O OH  . TYR A 1 126 ? 30.40400 -25.99300 -6.41000  1.000 43.08024 ? 126 TYR A OH  1 
ATOM   996  N N   . GLN A 1 127 ? 23.24400 -25.37500 -4.41700  1.000 31.52830 ? 127 GLN A N   1 
ATOM   997  C CA  . GLN A 1 127 ? 22.39000 -25.08000 -5.56000  1.000 31.63895 ? 127 GLN A CA  1 
ATOM   998  C C   . GLN A 1 127 ? 22.98700 -23.93400 -6.36500  1.000 32.72169 ? 127 GLN A C   1 
ATOM   999  O O   . GLN A 1 127 ? 23.34200 -22.89500 -5.80000  1.000 40.10312 ? 127 GLN A O   1 
ATOM   1000 C CB  . GLN A 1 127 ? 20.97900 -24.71500 -5.09100  1.000 36.93028 ? 127 GLN A CB  1 
ATOM   1001 C CG  . GLN A 1 127 ? 19.94200 -24.59300 -6.19700  1.000 36.41844 ? 127 GLN A CG  1 
ATOM   1002 C CD  . GLN A 1 127 ? 19.45100 -25.94200 -6.68700  1.000 38.70610 ? 127 GLN A CD  1 
ATOM   1003 O OE1 . GLN A 1 127 ? 19.87300 -26.98800 -6.19200  1.000 38.42721 ? 127 GLN A OE1 1 
ATOM   1004 N NE2 . GLN A 1 127 ? 18.55200 -25.92400 -7.66600  1.000 35.25414 ? 127 GLN A NE2 1 
ATOM   1005 N N   . CYS A 1 128 ? 23.09000 -24.12000 -7.67800  1.000 29.49108 ? 128 CYS A N   1 
ATOM   1006 C CA  A CYS A 1 128 ? 23.63600 -23.13300 -8.60000  0.469 36.04510 ? 128 CYS A CA  1 
ATOM   1007 C CA  B CYS A 1 128 ? 23.58300 -23.06500 -8.54900  0.531 35.91986 ? 128 CYS A CA  1 
ATOM   1008 C C   . CYS A 1 128 ? 22.68200 -22.93900 -9.76900  1.000 33.96663 ? 128 CYS A C   1 
ATOM   1009 O O   . CYS A 1 128 ? 21.73700 -23.70900 -9.96400  1.000 37.13012 ? 128 CYS A O   1 
ATOM   1010 C CB  A CYS A 1 128 ? 25.01300 -23.55300 -9.13400  0.469 34.19311 ? 128 CYS A CB  1 
ATOM   1011 C CB  B CYS A 1 128 ? 25.03400 -23.31500 -8.97700  0.531 34.49409 ? 128 CYS A CB  1 
ATOM   1012 S SG  A CYS A 1 128 ? 26.38600 -23.24700 -8.02300  0.469 42.17606 ? 128 CYS A SG  1 
ATOM   1013 S SG  B CYS A 1 128 ? 25.22500 -24.63600 -10.16600 0.531 35.03552 ? 128 CYS A SG  1 
ATOM   1014 N N   . ALA A 1 129 ? 22.97000 -21.92300 -10.57500 1.000 33.84729 ? 129 ALA A N   1 
ATOM   1015 C CA  . ALA A 1 129 ? 22.21600 -21.63300 -11.78400 1.000 33.76341 ? 129 ALA A CA  1 
ATOM   1016 C C   . ALA A 1 129 ? 23.17600 -21.51900 -12.95600 1.000 33.00385 ? 129 ALA A C   1 
ATOM   1017 O O   . ALA A 1 129 ? 24.30200 -21.03500 -12.80600 1.000 28.08727 ? 129 ALA A O   1 
ATOM   1018 C CB  . ALA A 1 129 ? 21.40700 -20.33600 -11.64500 1.000 35.56850 ? 129 ALA A CB  1 
ATOM   1019 N N   . MET A 1 130 ? 22.72900 -21.98300 -14.12000 1.000 32.07933 ? 130 MET A N   1 
ATOM   1020 C CA  . MET A 1 130 ? 23.47000 -21.78500 -15.35900 1.000 29.04827 ? 130 MET A CA  1 
ATOM   1021 C C   . MET A 1 130 ? 23.24300 -20.34900 -15.81800 1.000 33.40604 ? 130 MET A C   1 
ATOM   1022 O O   . MET A 1 130 ? 22.16100 -20.01500 -16.31100 1.000 35.40481 ? 130 MET A O   1 
ATOM   1023 C CB  . MET A 1 130 ? 23.01500 -22.78800 -16.41600 1.000 32.41743 ? 130 MET A CB  1 
ATOM   1024 C CG  . MET A 1 130 ? 23.72900 -22.66400 -17.75100 1.000 30.08896 ? 130 MET A CG  1 
ATOM   1025 S SD  . MET A 1 130 ? 25.49500 -22.99200 -17.60300 1.000 37.62162 ? 130 MET A SD  1 
ATOM   1026 C CE  . MET A 1 130 ? 25.47200 -24.67700 -16.99800 1.000 28.44943 ? 130 MET A CE  1 
ATOM   1027 N N   . ARG A 1 131 ? 24.25400 -19.49200 -15.64200 1.000 37.64593 ? 131 ARG A N   1 
ATOM   1028 C CA  . ARG A 1 131 ? 24.11200 -18.09000 -15.99500 1.000 33.42131 ? 131 ARG A CA  1 
ATOM   1029 C C   . ARG A 1 131 ? 23.83700 -17.95200 -17.49200 1.000 32.61046 ? 131 ARG A C   1 
ATOM   1030 O O   . ARG A 1 131 ? 24.14000 -18.85600 -18.27200 1.000 32.51436 ? 131 ARG A O   1 
ATOM   1031 C CB  . ARG A 1 131 ? 25.37300 -17.30900 -15.62100 1.000 30.19470 ? 131 ARG A CB  1 
ATOM   1032 C CG  . ARG A 1 131 ? 25.86400 -17.49100 -14.18200 1.000 38.31347 ? 131 ARG A CG  1 
ATOM   1033 C CD  . ARG A 1 131 ? 24.89300 -16.94100 -13.16000 1.000 40.22626 ? 131 ARG A CD  1 
ATOM   1034 N NE  . ARG A 1 131 ? 24.49400 -15.57700 -13.47800 1.000 42.67521 ? 131 ARG A NE  1 
ATOM   1035 C CZ  . ARG A 1 131 ? 23.47100 -14.95100 -12.91500 1.000 38.79846 ? 131 ARG A CZ  1 
ATOM   1036 N NH1 . ARG A 1 131 ? 22.75400 -15.52200 -11.96100 1.000 33.36307 ? 131 ARG A NH1 1 
ATOM   1037 N NH2 . ARG A 1 131 ? 23.15300 -13.72700 -13.32700 1.000 35.17103 ? 131 ARG A NH2 1 
ATOM   1038 N N   . PRO A 1 132 ? 23.24100 -16.83000 -17.91100 1.000 38.92571 ? 132 PRO A N   1 
ATOM   1039 C CA  . PRO A 1 132 ? 23.03000 -16.61000 -19.35200 1.000 35.22731 ? 132 PRO A CA  1 
ATOM   1040 C C   . PRO A 1 132 ? 24.29800 -16.71200 -20.18000 1.000 37.96569 ? 132 PRO A C   1 
ATOM   1041 O O   . PRO A 1 132 ? 24.22500 -17.11100 -21.34900 1.000 40.35247 ? 132 PRO A O   1 
ATOM   1042 C CB  . PRO A 1 132 ? 22.43800 -15.19500 -19.40000 1.000 31.71553 ? 132 PRO A CB  1 
ATOM   1043 C CG  . PRO A 1 132 ? 21.72400 -15.06200 -18.10200 1.000 35.40182 ? 132 PRO A CG  1 
ATOM   1044 C CD  . PRO A 1 132 ? 22.55600 -15.81300 -17.09300 1.000 37.34783 ? 132 PRO A CD  1 
ATOM   1045 N N   . ASN A 1 133 ? 25.45500 -16.36400 -19.61600 1.000 33.70690 ? 133 ASN A N   1 
ATOM   1046 C CA  . ASN A 1 133 ? 26.72800 -16.48800 -20.31200 1.000 30.17145 ? 133 ASN A CA  1 
ATOM   1047 C C   . ASN A 1 133 ? 27.35000 -17.87300 -20.15500 1.000 35.53968 ? 133 ASN A C   1 
ATOM   1048 O O   . ASN A 1 133 ? 28.54300 -18.04200 -20.43500 1.000 33.96714 ? 133 ASN A O   1 
ATOM   1049 C CB  . ASN A 1 133 ? 27.70300 -15.40700 -19.83000 1.000 30.89747 ? 133 ASN A CB  1 
ATOM   1050 C CG  . ASN A 1 133 ? 28.18100 -15.63000 -18.40200 1.000 38.14026 ? 133 ASN A CG  1 
ATOM   1051 O OD1 . ASN A 1 133 ? 27.63000 -16.44500 -17.66100 1.000 32.33524 ? 133 ASN A OD1 1 
ATOM   1052 N ND2 . ASN A 1 133 ? 29.21300 -14.89100 -18.00900 1.000 40.10906 ? 133 ASN A ND2 1 
ATOM   1053 N N   . PHE A 1 134 ? 26.56700 -18.85600 -19.70100 1.000 33.93730 ? 134 PHE A N   1 
ATOM   1054 C CA  . PHE A 1 134 ? 26.98500 -20.25900 -19.62900 1.000 34.88539 ? 134 PHE A CA  1 
ATOM   1055 C C   . PHE A 1 134 ? 28.16300 -20.46300 -18.67600 1.000 34.59987 ? 134 PHE A C   1 
ATOM   1056 O O   . PHE A 1 134 ? 29.06800 -21.25700 -18.93900 1.000 33.63736 ? 134 PHE A O   1 
ATOM   1057 C CB  . PHE A 1 134 ? 27.30700 -20.81300 -21.01800 1.000 32.17707 ? 134 PHE A CB  1 
ATOM   1058 C CG  . PHE A 1 134 ? 26.10600 -20.94300 -21.91300 1.000 31.35229 ? 134 PHE A CG  1 
ATOM   1059 C CD1 . PHE A 1 134 ? 25.21400 -21.99100 -21.75000 1.000 33.62983 ? 134 PHE A CD1 1 
ATOM   1060 C CD2 . PHE A 1 134 ? 25.87500 -20.02400 -22.92400 1.000 30.97609 ? 134 PHE A CD2 1 
ATOM   1061 C CE1 . PHE A 1 134 ? 24.11000 -22.11900 -22.57600 1.000 38.45085 ? 134 PHE A CE1 1 
ATOM   1062 C CE2 . PHE A 1 134 ? 24.77700 -20.14400 -23.75200 1.000 32.75166 ? 134 PHE A CE2 1 
ATOM   1063 C CZ  . PHE A 1 134 ? 23.89100 -21.19400 -23.57800 1.000 37.92559 ? 134 PHE A CZ  1 
ATOM   1064 N N   . THR A 1 135 ? 28.15000 -19.74300 -17.56000 1.000 32.85664 ? 135 THR A N   1 
ATOM   1065 C CA  . THR A 1 135 ? 29.05400 -19.98300 -16.44500 1.000 31.99741 ? 135 THR A CA  1 
ATOM   1066 C C   . THR A 1 135 ? 28.22900 -20.27900 -15.20000 1.000 35.51882 ? 135 THR A C   1 
ATOM   1067 O O   . THR A 1 135 ? 27.00300 -20.14000 -15.19400 1.000 36.64864 ? 135 THR A O   1 
ATOM   1068 C CB  . THR A 1 135 ? 29.97700 -18.78200 -16.19700 1.000 32.74507 ? 135 THR A CB  1 
ATOM   1069 O OG1 . THR A 1 135 ? 29.19000 -17.62500 -15.88800 1.000 34.83414 ? 135 THR A OG1 1 
ATOM   1070 C CG2 . THR A 1 135 ? 30.82400 -18.49700 -17.42800 1.000 34.99181 ? 135 THR A CG2 1 
ATOM   1071 N N   . ILE A 1 136 ? 28.90700 -20.71400 -14.13900 1.000 31.84872 ? 136 ILE A N   1 
ATOM   1072 C CA  . ILE A 1 136 ? 28.26500 -20.88500 -12.84200 1.000 33.42289 ? 136 ILE A CA  1 
ATOM   1073 C C   . ILE A 1 136 ? 29.14400 -20.24900 -11.77700 1.000 36.33681 ? 136 ILE A C   1 
ATOM   1074 O O   . ILE A 1 136 ? 30.35400 -20.08100 -11.95700 1.000 32.36064 ? 136 ILE A O   1 
ATOM   1075 C CB  . ILE A 1 136 ? 27.98300 -22.36500 -12.49300 1.000 30.76070 ? 136 ILE A CB  1 
ATOM   1076 C CG1 . ILE A 1 136 ? 29.28500 -23.13900 -12.28900 1.000 31.49161 ? 136 ILE A CG1 1 
ATOM   1077 C CG2 . ILE A 1 136 ? 27.12400 -23.02700 -13.56700 1.000 33.90914 ? 136 ILE A CG2 1 
ATOM   1078 C CD1 . ILE A 1 136 ? 29.06700 -24.55400 -11.80500 1.000 30.15249 ? 136 ILE A CD1 1 
ATOM   1079 N N   . LYS A 1 137 ? 28.51700 -19.88600 -10.66300 1.000 37.33603 ? 137 LYS A N   1 
ATOM   1080 C CA  . LYS A 1 137 ? 29.19300 -19.31000 -9.50700  1.000 35.83339 ? 137 LYS A CA  1 
ATOM   1081 C C   . LYS A 1 137 ? 29.20200 -20.37800 -8.41600  1.000 44.38191 ? 137 LYS A C   1 
ATOM   1082 O O   . LYS A 1 137 ? 28.34500 -20.40600 -7.53000  1.000 41.66228 ? 137 LYS A O   1 
ATOM   1083 C CB  . LYS A 1 137 ? 28.49700 -18.02700 -9.05000  1.000 31.31853 ? 137 LYS A CB  1 
ATOM   1084 C CG  . LYS A 1 137 ? 28.56400 -16.89200 -10.05800 1.000 36.25840 ? 137 LYS A CG  1 
ATOM   1085 C CD  . LYS A 1 137 ? 27.63600 -15.75200 -9.66700  1.000 47.61174 ? 137 LYS A CD  1 
ATOM   1086 C CE  . LYS A 1 137 ? 27.94200 -14.48200 -10.45600 1.000 48.92495 ? 137 LYS A CE  1 
ATOM   1087 N NZ  . LYS A 1 137 ? 29.29000 -13.93300 -10.12400 1.000 59.48106 ? 137 LYS A NZ  1 
ATOM   1088 N N   . GLY A 1 138 ? 30.19900 -21.25500 -8.48000  1.000 39.21763 ? 138 GLY A N   1 
ATOM   1089 C CA  . GLY A 1 138 ? 30.26600 -22.34200 -7.49900  1.000 38.15534 ? 138 GLY A CA  1 
ATOM   1090 C C   . GLY A 1 138 ? 31.43400 -22.23300 -6.54800  1.000 40.14906 ? 138 GLY A C   1 
ATOM   1091 O O   . GLY A 1 138 ? 32.00900 -21.14200 -6.43900  1.000 36.95151 ? 138 GLY A O   1 
ATOM   1092 N N   . SER A 1 139 ? 31.72200 -23.32000 -5.83800  1.000 41.20736 ? 139 SER A N   1 
ATOM   1093 C CA  . SER A 1 139 ? 32.86400 -23.37800 -4.89800  1.000 35.97368 ? 139 SER A CA  1 
ATOM   1094 C C   . SER A 1 139 ? 33.70200 -24.56700 -5.34700  1.000 41.10774 ? 139 SER A C   1 
ATOM   1095 O O   . SER A 1 139 ? 33.36800 -25.69700 -4.98400  1.000 48.98354 ? 139 SER A O   1 
ATOM   1096 C CB  . SER A 1 139 ? 32.40800 -23.53100 -3.49800  1.000 37.55354 ? 139 SER A CB  1 
ATOM   1097 O OG  . SER A 1 139 ? 33.47200 -23.29200 -2.59500  1.000 47.64797 ? 139 SER A OG  1 
ATOM   1098 N N   . PHE A 1 140 ? 34.72500 -24.30700 -6.14200  1.000 37.06253 ? 140 PHE A N   1 
ATOM   1099 C CA  . PHE A 1 140 ? 35.49200 -25.43000 -6.70900  1.000 37.43645 ? 140 PHE A CA  1 
ATOM   1100 C C   . PHE A 1 140 ? 36.96800 -25.16600 -6.45900  1.000 42.66831 ? 140 PHE A C   1 
ATOM   1101 O O   . PHE A 1 140 ? 37.44700 -24.08300 -6.80100  1.000 47.80811 ? 140 PHE A O   1 
ATOM   1102 C CB  . PHE A 1 140 ? 35.21200 -25.56300 -8.20300  1.000 37.59063 ? 140 PHE A CB  1 
ATOM   1103 C CG  . PHE A 1 140 ? 33.87300 -26.13800 -8.58100  1.000 38.31951 ? 140 PHE A CG  1 
ATOM   1104 C CD1 . PHE A 1 140 ? 33.58400 -27.47100 -8.36100  1.000 33.18961 ? 140 PHE A CD1 1 
ATOM   1105 C CD2 . PHE A 1 140 ? 32.91200 -25.34800 -9.18400  1.000 35.60948 ? 140 PHE A CD2 1 
ATOM   1106 C CE1 . PHE A 1 140 ? 32.35900 -27.99700 -8.72700  1.000 36.87835 ? 140 PHE A CE1 1 
ATOM   1107 C CE2 . PHE A 1 140 ? 31.68900 -25.87500 -9.55400  1.000 33.26108 ? 140 PHE A CE2 1 
ATOM   1108 C CZ  . PHE A 1 140 ? 31.41600 -27.20000 -9.32600  1.000 37.46737 ? 140 PHE A CZ  1 
ATOM   1109 N N   . LEU A 1 141 ? 37.64600 -26.14300 -5.87600  1.000 39.81073 ? 141 LEU A N   1 
ATOM   1110 C CA  . LEU A 1 141 ? 39.09400 -26.00000 -5.63200  1.000 41.51884 ? 141 LEU A CA  1 
ATOM   1111 C C   . LEU A 1 141 ? 39.84600 -26.97800 -6.52600  1.000 43.42777 ? 141 LEU A C   1 
ATOM   1112 O O   . LEU A 1 141 ? 39.22200 -27.59800 -7.38500  1.000 43.49626 ? 141 LEU A O   1 
ATOM   1113 C CB  . LEU A 1 141 ? 39.38700 -26.28400 -4.15700  1.000 39.07855 ? 141 LEU A CB  1 
ATOM   1114 C CG  . LEU A 1 141 ? 38.72400 -25.35200 -3.15000  1.000 45.71117 ? 141 LEU A CG  1 
ATOM   1115 C CD1 . LEU A 1 141 ? 38.77800 -25.95700 -1.75900  1.000 46.10858 ? 141 LEU A CD1 1 
ATOM   1116 C CD2 . LEU A 1 141 ? 39.39400 -23.99000 -3.16400  1.000 48.24150 ? 141 LEU A CD2 1 
ATOM   1117 N N   . ASN A 1 142 ? 41.15100 -27.08300 -6.31000  1.000 49.00345 ? 142 ASN A N   1 
ATOM   1118 C CA  . ASN A 1 142 ? 41.98300 -28.03700 -7.07500  1.000 39.86557 ? 142 ASN A CA  1 
ATOM   1119 C C   . ASN A 1 142 ? 41.56300 -29.45500 -6.68300  1.000 42.44018 ? 142 ASN A C   1 
ATOM   1120 O O   . ASN A 1 142 ? 41.52300 -29.75000 -5.48600  1.000 38.23511 ? 142 ASN A O   1 
ATOM   1121 C CB  . ASN A 1 142 ? 43.46700 -27.74000 -6.86700  1.000 38.40225 ? 142 ASN A CB  1 
ATOM   1122 C CG  . ASN A 1 142 ? 43.93900 -26.51100 -7.60900  1.000 55.06502 ? 142 ASN A CG  1 
ATOM   1123 O OD1 . ASN A 1 142 ? 44.63100 -26.62100 -8.61700  1.000 59.00751 ? 142 ASN A OD1 1 
ATOM   1124 N ND2 . ASN A 1 142 ? 43.57700 -25.33900 -7.11600  1.000 60.93573 ? 142 ASN A ND2 1 
ATOM   1125 N N   . GLY A 1 143 ? 41.24400 -30.28500 -7.67300  1.000 40.57894 ? 143 GLY A N   1 
ATOM   1126 C CA  . GLY A 1 143 ? 40.77400 -31.65100 -7.40200  1.000 38.15789 ? 143 GLY A CA  1 
ATOM   1127 C C   . GLY A 1 143 ? 39.27300 -31.76700 -7.53300  1.000 38.88790 ? 143 GLY A C   1 
ATOM   1128 O O   . GLY A 1 143 ? 38.77500 -32.88700 -7.45200  1.000 44.38740 ? 143 GLY A O   1 
ATOM   1129 N N   . SER A 1 144 ? 38.58200 -30.65100 -7.73900  1.000 37.15801 ? 144 SER A N   1 
ATOM   1130 C CA  . SER A 1 144 ? 37.12700 -30.72600 -7.77100  1.000 42.56118 ? 144 SER A CA  1 
ATOM   1131 C C   . SER A 1 144 ? 36.57500 -31.16200 -9.12200  1.000 41.81582 ? 144 SER A C   1 
ATOM   1132 O O   . SER A 1 144 ? 35.37100 -31.43000 -9.21600  1.000 33.68804 ? 144 SER A O   1 
ATOM   1133 C CB  . SER A 1 144 ? 36.51600 -29.37200 -7.40400  1.000 38.32542 ? 144 SER A CB  1 
ATOM   1134 O OG  . SER A 1 144 ? 36.72000 -28.43500 -8.44500  1.000 38.17198 ? 144 SER A OG  1 
ATOM   1135 N N   . CYS A 1 145 ? 37.40800 -31.22600 -10.16100 1.000 34.87975 ? 145 CYS A N   1 
ATOM   1136 C CA  . CYS A 1 145 ? 36.91200 -31.58700 -11.48100 1.000 34.64294 ? 145 CYS A CA  1 
ATOM   1137 C C   . CYS A 1 145 ? 36.31500 -32.98800 -11.46000 1.000 33.14655 ? 145 CYS A C   1 
ATOM   1138 O O   . CYS A 1 145 ? 36.71900 -33.85000 -10.67600 1.000 33.30657 ? 145 CYS A O   1 
ATOM   1139 C CB  . CYS A 1 145 ? 38.02800 -31.49800 -12.51900 1.000 32.60353 ? 145 CYS A CB  1 
ATOM   1140 S SG  . CYS A 1 145 ? 38.53300 -29.80400 -12.90000 1.000 34.93067 ? 145 CYS A SG  1 
ATOM   1141 N N   . GLY A 1 146 ? 35.33400 -33.20900 -12.33300 1.000 33.58445 ? 146 GLY A N   1 
ATOM   1142 C CA  . GLY A 1 146 ? 34.54900 -34.41700 -12.31600 1.000 33.30814 ? 146 GLY A CA  1 
ATOM   1143 C C   . GLY A 1 146 ? 33.32200 -34.34900 -11.43600 1.000 29.02743 ? 146 GLY A C   1 
ATOM   1144 O O   . GLY A 1 146 ? 32.45300 -35.22200 -11.54300 1.000 29.80473 ? 146 GLY A O   1 
ATOM   1145 N N   . SER A 1 147 ? 33.23700 -33.34800 -10.56000 1.000 27.79570 ? 147 SER A N   1 
ATOM   1146 C CA  . SER A 1 147 ? 32.00800 -33.09600 -9.82200  1.000 28.28148 ? 147 SER A CA  1 
ATOM   1147 C C   . SER A 1 147 ? 30.88200 -32.78300 -10.79800 1.000 35.21737 ? 147 SER A C   1 
ATOM   1148 O O   . SER A 1 147 ? 31.09600 -32.13800 -11.83100 1.000 33.10880 ? 147 SER A O   1 
ATOM   1149 C CB  . SER A 1 147 ? 32.20100 -31.93500 -8.84700  1.000 32.47816 ? 147 SER A CB  1 
ATOM   1150 O OG  . SER A 1 147 ? 33.24500 -32.21500 -7.92900  1.000 38.40622 ? 147 SER A OG  1 
ATOM   1151 N N   . VAL A 1 148 ? 29.67800 -33.24600 -10.47000 1.000 28.88706 ? 148 VAL A N   1 
ATOM   1152 C CA  . VAL A 1 148 ? 28.56600 -33.20300 -11.40700 1.000 30.01282 ? 148 VAL A CA  1 
ATOM   1153 C C   . VAL A 1 148 ? 27.43400 -32.35700 -10.84400 1.000 28.96288 ? 148 VAL A C   1 
ATOM   1154 O O   . VAL A 1 148 ? 27.25000 -32.25100 -9.62600  1.000 27.28975 ? 148 VAL A O   1 
ATOM   1155 C CB  . VAL A 1 148 ? 28.07000 -34.62300 -11.75300 1.000 24.70281 ? 148 VAL A CB  1 
ATOM   1156 C CG1 . VAL A 1 148 ? 29.18600 -35.41800 -12.39900 1.000 31.02139 ? 148 VAL A CG1 1 
ATOM   1157 C CG2 . VAL A 1 148 ? 27.57200 -35.32600 -10.50700 1.000 29.27085 ? 148 VAL A CG2 1 
ATOM   1158 N N   . GLY A 1 149 ? 26.67900 -31.74100 -11.75300 1.000 30.15221 ? 149 GLY A N   1 
ATOM   1159 C CA  . GLY A 1 149 ? 25.45100 -31.04300 -11.42100 1.000 28.71126 ? 149 GLY A CA  1 
ATOM   1160 C C   . GLY A 1 149 ? 24.26300 -31.84400 -11.91900 1.000 28.21283 ? 149 GLY A C   1 
ATOM   1161 O O   . GLY A 1 149 ? 24.35100 -32.52800 -12.94000 1.000 27.98231 ? 149 GLY A O   1 
ATOM   1162 N N   . PHE A 1 150 ? 23.17700 -31.73400 -11.17700 1.000 26.38843 ? 150 PHE A N   1 
ATOM   1163 C CA  . PHE A 1 150 ? 22.03100 -32.60300 -11.47900 1.000 33.10295 ? 150 PHE A CA  1 
ATOM   1164 C C   . PHE A 1 150 ? 20.71500 -32.06600 -10.92700 1.000 34.63249 ? 150 PHE A C   1 
ATOM   1165 O O   . PHE A 1 150 ? 20.70600 -31.18800 -10.06200 1.000 31.05289 ? 150 PHE A O   1 
ATOM   1166 C CB  . PHE A 1 150 ? 22.25300 -33.95300 -10.79200 1.000 28.74819 ? 150 PHE A CB  1 
ATOM   1167 C CG  . PHE A 1 150 ? 22.46600 -33.86800 -9.30100  1.000 30.06084 ? 150 PHE A CG  1 
ATOM   1168 C CD1 . PHE A 1 150 ? 23.71500 -33.58600 -8.77500  1.000 29.69770 ? 150 PHE A CD1 1 
ATOM   1169 C CD2 . PHE A 1 150 ? 21.41600 -34.06800 -8.42100  1.000 30.05780 ? 150 PHE A CD2 1 
ATOM   1170 C CE1 . PHE A 1 150 ? 23.90600 -33.49100 -7.40700  1.000 31.83438 ? 150 PHE A CE1 1 
ATOM   1171 C CE2 . PHE A 1 150 ? 21.60900 -33.97600 -7.05400  1.000 33.28172 ? 150 PHE A CE2 1 
ATOM   1172 C CZ  . PHE A 1 150 ? 22.85300 -33.69000 -6.55000  1.000 30.22688 ? 150 PHE A CZ  1 
ATOM   1173 N N   . ASN A 1 151 ? 19.62900 -32.65000 -11.40300 1.000 32.00068 ? 151 ASN A N   1 
ATOM   1174 C CA  . ASN A 1 151 ? 18.29500 -32.32400 -10.86600 1.000 37.36366 ? 151 ASN A CA  1 
ATOM   1175 C C   . ASN A 1 151 ? 17.67900 -33.67600 -10.49500 1.000 40.33089 ? 151 ASN A C   1 
ATOM   1176 O O   . ASN A 1 151 ? 18.12800 -34.68600 -11.04700 1.000 37.87459 ? 151 ASN A O   1 
ATOM   1177 C CB  . ASN A 1 151 ? 17.48100 -31.49200 -11.85800 1.000 35.97052 ? 151 ASN A CB  1 
ATOM   1178 C CG  . ASN A 1 151 ? 17.91500 -30.04600 -11.94800 1.000 42.97502 ? 151 ASN A CG  1 
ATOM   1179 O OD1 . ASN A 1 151 ? 18.59800 -29.65400 -12.88700 1.000 46.50741 ? 151 ASN A OD1 1 
ATOM   1180 N ND2 . ASN A 1 151 ? 17.54400 -29.24700 -10.96400 1.000 42.42992 ? 151 ASN A ND2 1 
ATOM   1181 N N   . ILE A 1 152 ? 16.71900 -33.70400 -9.57700  1.000 41.18271 ? 152 ILE A N   1 
ATOM   1182 C CA  . ILE A 1 152 ? 16.02400 -34.98500 -9.26900  1.000 41.14241 ? 152 ILE A CA  1 
ATOM   1183 C C   . ILE A 1 152 ? 14.51700 -34.85400 -9.50000  1.000 48.38882 ? 152 ILE A C   1 
ATOM   1184 O O   . ILE A 1 152 ? 13.93900 -33.89300 -8.99900  1.000 50.08899 ? 152 ILE A O   1 
ATOM   1185 C CB  . ILE A 1 152 ? 16.34700 -35.49400 -7.84800  1.000 41.55604 ? 152 ILE A CB  1 
ATOM   1186 C CG1 . ILE A 1 152 ? 17.81800 -35.29400 -7.48200  1.000 35.28598 ? 152 ILE A CG1 1 
ATOM   1187 C CG2 . ILE A 1 152 ? 15.91700 -36.94300 -7.68800  1.000 42.34138 ? 152 ILE A CG2 1 
ATOM   1188 C CD1 . ILE A 1 152 ? 18.64000 -36.54800 -7.56700  1.000 48.79248 ? 152 ILE A CD1 1 
ATOM   1189 N N   . ASP A 1 153 ? 13.92200 -35.76800 -10.26900 1.000 54.05048 ? 153 ASP A N   1 
ATOM   1190 C CA  . ASP A 1 153 ? 12.47800 -35.85600 -10.48900 1.000 51.00990 ? 153 ASP A CA  1 
ATOM   1191 C C   . ASP A 1 153 ? 12.02000 -37.19100 -9.90800  1.000 49.40679 ? 153 ASP A C   1 
ATOM   1192 O O   . ASP A 1 153 ? 12.19500 -38.24000 -10.53600 1.000 51.39281 ? 153 ASP A O   1 
ATOM   1193 C CB  . ASP A 1 153 ? 12.12800 -35.73700 -11.97000 1.000 53.66901 ? 153 ASP A CB  1 
ATOM   1194 C CG  . ASP A 1 153 ? 10.62600 -35.68800 -12.21600 1.000 66.90359 ? 153 ASP A CG  1 
ATOM   1195 O OD1 . ASP A 1 153 ? 9.85700  -35.61500 -11.23400 1.000 65.40110 ? 153 ASP A OD1 1 
ATOM   1196 O OD2 . ASP A 1 153 ? 10.21300 -35.72300 -13.39500 1.000 75.28389 ? 153 ASP A OD2 1 
ATOM   1197 N N   . TYR A 1 154 ? 11.43000 -37.14100 -8.71200  1.000 49.45444 ? 154 TYR A N   1 
ATOM   1198 C CA  . TYR A 1 154 ? 11.04000 -38.33200 -7.96500  1.000 50.27174 ? 154 TYR A CA  1 
ATOM   1199 C C   . TYR A 1 154 ? 12.23100 -39.26400 -7.77500  1.000 49.73939 ? 154 TYR A C   1 
ATOM   1200 O O   . TYR A 1 154 ? 12.94100 -39.17200 -6.76800  1.000 53.25323 ? 154 TYR A O   1 
ATOM   1201 C CB  . TYR A 1 154 ? 9.88300  -39.06100 -8.65600  1.000 54.79612 ? 154 TYR A CB  1 
ATOM   1202 C CG  . TYR A 1 154 ? 9.39600  -40.28100 -7.90100  1.000 57.20434 ? 154 TYR A CG  1 
ATOM   1203 C CD1 . TYR A 1 154 ? 9.09800  -40.20900 -6.54400  1.000 62.90283 ? 154 TYR A CD1 1 
ATOM   1204 C CD2 . TYR A 1 154 ? 9.22700  -41.50100 -8.54400  1.000 53.50924 ? 154 TYR A CD2 1 
ATOM   1205 C CE1 . TYR A 1 154 ? 8.65400  -41.32000 -5.84700  1.000 58.56745 ? 154 TYR A CE1 1 
ATOM   1206 C CE2 . TYR A 1 154 ? 8.78100  -42.61700 -7.85600  1.000 60.53597 ? 154 TYR A CE2 1 
ATOM   1207 C CZ  . TYR A 1 154 ? 8.49700  -42.52100 -6.50800  1.000 61.96684 ? 154 TYR A CZ  1 
ATOM   1208 O OH  . TYR A 1 154 ? 8.05500  -43.62900 -5.82100  1.000 68.92291 ? 154 TYR A OH  1 
ATOM   1209 N N   . ASP A 1 155 ? 12.46500 -40.16200 -8.73100  1.000 48.69337 ? 155 ASP A N   1 
ATOM   1210 C CA  . ASP A 1 155 ? 13.58000 -41.09400 -8.64800  1.000 48.92052 ? 155 ASP A CA  1 
ATOM   1211 C C   . ASP A 1 155 ? 14.52100 -41.01700 -9.84200  1.000 45.85166 ? 155 ASP A C   1 
ATOM   1212 O O   . ASP A 1 155 ? 15.46000 -41.81900 -9.92200  1.000 48.78722 ? 155 ASP A O   1 
ATOM   1213 C CB  . ASP A 1 155 ? 13.06800 -42.53500 -8.48700  1.000 53.02806 ? 155 ASP A CB  1 
ATOM   1214 C CG  . ASP A 1 155 ? 12.06800 -42.93300 -9.56200  1.000 53.15933 ? 155 ASP A CG  1 
ATOM   1215 O OD1 . ASP A 1 155 ? 11.83800 -42.14300 -10.50400 1.000 49.74735 ? 155 ASP A OD1 1 
ATOM   1216 O OD2 . ASP A 1 155 ? 11.50100 -44.04300 -9.45600  1.000 56.14214 ? 155 ASP A OD2 1 
ATOM   1217 N N   . CYS A 1 156 ? 14.30500 -40.08000 -10.76200 1.000 39.51125 ? 156 CYS A N   1 
ATOM   1218 C CA  . CYS A 1 156 ? 15.13300 -39.93800 -11.95100 1.000 44.78887 ? 156 CYS A CA  1 
ATOM   1219 C C   . CYS A 1 156 ? 16.14200 -38.81600 -11.73000 1.000 42.92732 ? 156 CYS A C   1 
ATOM   1220 O O   . CYS A 1 156 ? 15.75600 -37.66800 -11.48100 1.000 41.00703 ? 156 CYS A O   1 
ATOM   1221 C CB  . CYS A 1 156 ? 14.27400 -39.65300 -13.18200 1.000 41.11531 ? 156 CYS A CB  1 
ATOM   1222 S SG  . CYS A 1 156 ? 15.17100 -39.78900 -14.75000 1.000 52.09940 ? 156 CYS A SG  1 
ATOM   1223 N N   . VAL A 1 157 ? 17.42600 -39.14800 -11.82300 1.000 36.59148 ? 157 VAL A N   1 
ATOM   1224 C CA  . VAL A 1 157 ? 18.49700 -38.16600 -11.71200 1.000 35.97273 ? 157 VAL A CA  1 
ATOM   1225 C C   . VAL A 1 157 ? 18.84500 -37.67600 -13.11200 1.000 34.26379 ? 157 VAL A C   1 
ATOM   1226 O O   . VAL A 1 157 ? 19.23700 -38.46700 -13.97500 1.000 32.66869 ? 157 VAL A O   1 
ATOM   1227 C CB  . VAL A 1 157 ? 19.73000 -38.76100 -11.01600 1.000 32.85684 ? 157 VAL A CB  1 
ATOM   1228 C CG1 . VAL A 1 157 ? 20.77700 -37.68100 -10.77800 1.000 28.65848 ? 157 VAL A CG1 1 
ATOM   1229 C CG2 . VAL A 1 157 ? 19.33300 -39.43100 -9.70900  1.000 30.30109 ? 157 VAL A CG2 1 
ATOM   1230 N N   . SER A 1 158 ? 18.69400 -36.37400 -13.34300 1.000 33.81649 ? 158 SER A N   1 
ATOM   1231 C CA  . SER A 1 158 ? 19.04100 -35.76000 -14.62400 1.000 30.51802 ? 158 SER A CA  1 
ATOM   1232 C C   . SER A 1 158 ? 20.38900 -35.06700 -14.46000 1.000 32.82768 ? 158 SER A C   1 
ATOM   1233 O O   . SER A 1 158 ? 20.47200 -33.92200 -14.01600 1.000 31.56560 ? 158 SER A O   1 
ATOM   1234 C CB  . SER A 1 158 ? 17.96300 -34.78500 -15.08200 1.000 29.63038 ? 158 SER A CB  1 
ATOM   1235 O OG  . SER A 1 158 ? 16.79800 -35.46800 -15.50600 1.000 42.00710 ? 158 SER A OG  1 
ATOM   1236 N N   . PHE A 1 159 ? 21.45400 -35.77300 -14.82100 1.000 33.51898 ? 159 PHE A N   1 
ATOM   1237 C CA  . PHE A 1 159 ? 22.77700 -35.16600 -14.82600 1.000 31.79698 ? 159 PHE A CA  1 
ATOM   1238 C C   . PHE A 1 159 ? 22.87600 -34.15700 -15.96300 1.000 30.39389 ? 159 PHE A C   1 
ATOM   1239 O O   . PHE A 1 159 ? 22.50800 -34.45300 -17.10600 1.000 29.35485 ? 159 PHE A O   1 
ATOM   1240 C CB  . PHE A 1 159 ? 23.85100 -36.24400 -14.96300 1.000 25.14419 ? 159 PHE A CB  1 
ATOM   1241 C CG  . PHE A 1 159 ? 23.87500 -37.21700 -13.81800 1.000 28.10993 ? 159 PHE A CG  1 
ATOM   1242 C CD1 . PHE A 1 159 ? 24.49100 -36.88100 -12.62300 1.000 23.77448 ? 159 PHE A CD1 1 
ATOM   1243 C CD2 . PHE A 1 159 ? 23.27300 -38.45900 -13.93200 1.000 28.08329 ? 159 PHE A CD2 1 
ATOM   1244 C CE1 . PHE A 1 159 ? 24.51500 -37.76900 -11.56800 1.000 27.89901 ? 159 PHE A CE1 1 
ATOM   1245 C CE2 . PHE A 1 159 ? 23.28900 -39.35500 -12.87700 1.000 23.79200 ? 159 PHE A CE2 1 
ATOM   1246 C CZ  . PHE A 1 159 ? 23.90800 -39.01200 -11.69600 1.000 30.17576 ? 159 PHE A CZ  1 
ATOM   1247 N N   . CYS A 1 160 ? 23.36800 -32.95600 -15.64600 1.000 24.52052 ? 160 CYS A N   1 
ATOM   1248 C CA  . CYS A 1 160 ? 23.45500 -31.88400 -16.62500 1.000 25.11889 ? 160 CYS A CA  1 
ATOM   1249 C C   . CYS A 1 160 ? 24.79900 -31.17100 -16.67300 1.000 27.42257 ? 160 CYS A C   1 
ATOM   1250 O O   . CYS A 1 160 ? 25.03500 -30.42500 -17.63000 1.000 30.29971 ? 160 CYS A O   1 
ATOM   1251 C CB  . CYS A 1 160 ? 22.35900 -30.83600 -16.37000 1.000 29.03318 ? 160 CYS A CB  1 
ATOM   1252 S SG  . CYS A 1 160 ? 22.41400 -30.05900 -14.72700 1.000 33.66891 ? 160 CYS A SG  1 
ATOM   1253 N N   . TYR A 1 161 ? 25.68300 -31.36700 -15.69600 1.000 26.99898 ? 161 TYR A N   1 
ATOM   1254 C CA  . TYR A 1 161 ? 26.89900 -30.57100 -15.61600 1.000 28.46760 ? 161 TYR A CA  1 
ATOM   1255 C C   . TYR A 1 161 ? 28.04800 -31.41400 -15.08500 1.000 27.96819 ? 161 TYR A C   1 
ATOM   1256 O O   . TYR A 1 161 ? 27.85800 -32.27500 -14.22200 1.000 24.04204 ? 161 TYR A O   1 
ATOM   1257 C CB  . TYR A 1 161 ? 26.69900 -29.34600 -14.71300 1.000 28.59134 ? 161 TYR A CB  1 
ATOM   1258 C CG  . TYR A 1 161 ? 27.92100 -28.46500 -14.58200 1.000 26.07606 ? 161 TYR A CG  1 
ATOM   1259 C CD1 . TYR A 1 161 ? 28.22200 -27.52200 -15.55200 1.000 28.81731 ? 161 TYR A CD1 1 
ATOM   1260 C CD2 . TYR A 1 161 ? 28.76900 -28.57200 -13.48600 1.000 25.09047 ? 161 TYR A CD2 1 
ATOM   1261 C CE1 . TYR A 1 161 ? 29.33500 -26.70900 -15.44000 1.000 29.32469 ? 161 TYR A CE1 1 
ATOM   1262 C CE2 . TYR A 1 161 ? 29.88500 -27.76400 -13.36500 1.000 26.95695 ? 161 TYR A CE2 1 
ATOM   1263 C CZ  . TYR A 1 161 ? 30.16200 -26.83300 -14.34600 1.000 28.40092 ? 161 TYR A CZ  1 
ATOM   1264 O OH  . TYR A 1 161 ? 31.26900 -26.02400 -14.24200 1.000 27.03520 ? 161 TYR A OH  1 
ATOM   1265 N N   . MET A 1 162 ? 29.24600 -31.14900 -15.60400 1.000 25.68360 ? 162 MET A N   1 
ATOM   1266 C CA  . MET A 1 162 ? 30.47600 -31.71200 -15.05600 1.000 30.05218 ? 162 MET A CA  1 
ATOM   1267 C C   . MET A 1 162 ? 31.53700 -30.62300 -15.03600 1.000 29.06802 ? 162 MET A C   1 
ATOM   1268 O O   . MET A 1 162 ? 31.79200 -29.99100 -16.06400 1.000 28.38973 ? 162 MET A O   1 
ATOM   1269 C CB  . MET A 1 162 ? 30.95400 -32.91800 -15.86700 1.000 24.53877 ? 162 MET A CB  1 
ATOM   1270 C CG  . MET A 1 162 ? 32.24700 -33.51500 -15.35200 1.000 28.37402 ? 162 MET A CG  1 
ATOM   1271 S SD  . MET A 1 162 ? 32.64600 -35.09800 -16.11600 1.000 32.79914 ? 162 MET A SD  1 
ATOM   1272 C CE  . MET A 1 162 ? 31.62500 -36.20900 -15.15100 1.000 32.76624 ? 162 MET A CE  1 
ATOM   1273 N N   . HIS A 1 163 ? 32.15300 -30.40700 -13.87500 1.000 30.26424 ? 163 HIS A N   1 
ATOM   1274 C CA  . HIS A 1 163 ? 33.07400 -29.29000 -13.71800 1.000 29.06402 ? 163 HIS A CA  1 
ATOM   1275 C C   . HIS A 1 163 ? 34.40400 -29.57100 -14.40500 1.000 28.90604 ? 163 HIS A C   1 
ATOM   1276 O O   . HIS A 1 163 ? 34.91600 -30.69300 -14.36800 1.000 29.15876 ? 163 HIS A O   1 
ATOM   1277 C CB  . HIS A 1 163 ? 33.30800 -28.99700 -12.23900 1.000 29.80303 ? 163 HIS A CB  1 
ATOM   1278 C CG  . HIS A 1 163 ? 34.22800 -27.84300 -11.99900 1.000 30.81217 ? 163 HIS A CG  1 
ATOM   1279 N ND1 . HIS A 1 163 ? 33.93700 -26.56400 -12.42000 1.000 28.87094 ? 163 HIS A ND1 1 
ATOM   1280 C CD2 . HIS A 1 163 ? 35.44000 -27.77600 -11.39900 1.000 31.80407 ? 163 HIS A CD2 1 
ATOM   1281 C CE1 . HIS A 1 163 ? 34.92600 -25.75600 -12.08100 1.000 34.16548 ? 163 HIS A CE1 1 
ATOM   1282 N NE2 . HIS A 1 163 ? 35.85100 -26.46700 -11.46200 1.000 36.63872 ? 163 HIS A NE2 1 
ATOM   1283 N N   . HIS A 1 164 ? 34.97400 -28.53500 -15.02200 1.000 29.20135 ? 164 HIS A N   1 
ATOM   1284 C CA  . HIS A 1 164 ? 36.23600 -28.67100 -15.74500 1.000 30.26496 ? 164 HIS A CA  1 
ATOM   1285 C C   . HIS A 1 164 ? 37.28000 -27.63300 -15.36500 1.000 32.60662 ? 164 HIS A C   1 
ATOM   1286 O O   . HIS A 1 164 ? 38.46800 -27.96000 -15.34100 1.000 40.57975 ? 164 HIS A O   1 
ATOM   1287 C CB  . HIS A 1 164 ? 36.00500 -28.60200 -17.26300 1.000 28.50254 ? 164 HIS A CB  1 
ATOM   1288 C CG  . HIS A 1 164 ? 35.53500 -29.88900 -17.86800 1.000 26.51052 ? 164 HIS A CG  1 
ATOM   1289 N ND1 . HIS A 1 164 ? 34.29600 -30.43000 -17.59900 1.000 28.69376 ? 164 HIS A ND1 1 
ATOM   1290 C CD2 . HIS A 1 164 ? 36.13500 -30.73700 -18.73500 1.000 23.15625 ? 164 HIS A CD2 1 
ATOM   1291 C CE1 . HIS A 1 164 ? 34.15500 -31.55900 -18.27000 1.000 27.75464 ? 164 HIS A CE1 1 
ATOM   1292 N NE2 . HIS A 1 164 ? 35.25600 -31.76700 -18.96900 1.000 30.15189 ? 164 HIS A NE2 1 
ATOM   1293 N N   . MET A 1 165 ? 36.88300 -26.39300 -15.08500 1.000 30.82082 ? 165 MET A N   1 
ATOM   1294 C CA  . MET A 1 165 ? 37.88100 -25.34600 -14.89700 1.000 38.24103 ? 165 MET A CA  1 
ATOM   1295 C C   . MET A 1 165 ? 37.23900 -24.10500 -14.29200 1.000 36.73043 ? 165 MET A C   1 
ATOM   1296 O O   . MET A 1 165 ? 36.01400 -23.97600 -14.23000 1.000 34.69788 ? 165 MET A O   1 
ATOM   1297 C CB  . MET A 1 165 ? 38.55600 -24.99600 -16.22100 1.000 35.04852 ? 165 MET A CB  1 
ATOM   1298 C CG  . MET A 1 165 ? 37.58000 -24.52500 -17.26100 1.000 34.45068 ? 165 MET A CG  1 
ATOM   1299 S SD  . MET A 1 165 ? 38.35000 -24.42900 -18.87400 1.000 52.47394 ? 165 MET A SD  1 
ATOM   1300 C CE  . MET A 1 165 ? 37.01700 -23.68000 -19.78800 1.000 35.71392 ? 165 MET A CE  1 
ATOM   1301 N N   . VAL A 1 166 ? 38.10000 -23.18500 -13.85700 1.000 34.34002 ? 166 VAL A N   1 
ATOM   1302 C CA  . VAL A 1 166 ? 37.70100 -21.87200 -13.36600 1.000 35.35932 ? 166 VAL A CA  1 
ATOM   1303 C C   . VAL A 1 166 ? 38.21900 -20.82200 -14.33900 1.000 35.18548 ? 166 VAL A C   1 
ATOM   1304 O O   . VAL A 1 166 ? 39.27300 -20.98700 -14.96300 1.000 39.68356 ? 166 VAL A O   1 
ATOM   1305 C CB  . VAL A 1 166 ? 38.22300 -21.60800 -11.93500 1.000 36.34458 ? 166 VAL A CB  1 
ATOM   1306 C CG1 . VAL A 1 166 ? 39.74200 -21.61800 -11.90600 1.000 33.16884 ? 166 VAL A CG1 1 
ATOM   1307 C CG2 . VAL A 1 166 ? 37.68400 -20.28900 -11.39300 1.000 31.46570 ? 166 VAL A CG2 1 
ATOM   1308 N N   . LEU A 1 167 ? 37.46200 -19.74700 -14.48100 1.000 36.71091 ? 167 LEU A N   1 
ATOM   1309 C CA  . LEU A 1 167 ? 37.83700 -18.63700 -15.34500 1.000 38.22491 ? 167 LEU A CA  1 
ATOM   1310 C C   . LEU A 1 167 ? 38.62300 -17.60500 -14.55400 1.000 45.30549 ? 167 LEU A C   1 
ATOM   1311 O O   . LEU A 1 167 ? 38.67900 -17.65300 -13.32100 1.000 44.01479 ? 167 LEU A O   1 
ATOM   1312 C CB  . LEU A 1 167 ? 36.58300 -18.02500 -15.96600 1.000 37.37866 ? 167 LEU A CB  1 
ATOM   1313 C CG  . LEU A 1 167 ? 35.76500 -18.93100 -16.89100 1.000 38.31826 ? 167 LEU A CG  1 
ATOM   1314 C CD1 . LEU A 1 167 ? 34.73700 -18.11400 -17.65400 1.000 42.50503 ? 167 LEU A CD1 1 
ATOM   1315 C CD2 . LEU A 1 167 ? 36.66400 -19.69700 -17.84900 1.000 32.37957 ? 167 LEU A CD2 1 
ATOM   1316 N N   . PRO A 1 168 ? 39.27700 -16.65900 -15.23900 1.000 46.39613 ? 168 PRO A N   1 
ATOM   1317 C CA  . PRO A 1 168 ? 39.99900 -15.60200 -14.51000 1.000 41.87631 ? 168 PRO A CA  1 
ATOM   1318 C C   . PRO A 1 168 ? 39.12600 -14.80300 -13.56000 1.000 44.94367 ? 168 PRO A C   1 
ATOM   1319 O O   . PRO A 1 168 ? 39.62500 -14.34000 -12.52600 1.000 45.16224 ? 168 PRO A O   1 
ATOM   1320 C CB  . PRO A 1 168 ? 40.55400 -14.72400 -15.63900 1.000 43.71938 ? 168 PRO A CB  1 
ATOM   1321 C CG  . PRO A 1 168 ? 40.73400 -15.66400 -16.77700 1.000 42.17297 ? 168 PRO A CG  1 
ATOM   1322 C CD  . PRO A 1 168 ? 39.59200 -16.64100 -16.68000 1.000 48.98175 ? 168 PRO A CD  1 
ATOM   1323 N N   . THR A 1 169 ? 37.84000 -14.62800 -13.86800 1.000 43.80619 ? 169 THR A N   1 
ATOM   1324 C CA  . THR A 1 169 ? 36.94900 -13.86700 -12.99900 1.000 41.70144 ? 169 THR A CA  1 
ATOM   1325 C C   . THR A 1 169 ? 36.49400 -14.65100 -11.77500 1.000 41.36585 ? 169 THR A C   1 
ATOM   1326 O O   . THR A 1 169 ? 35.73700 -14.10900 -10.96100 1.000 44.86448 ? 169 THR A O   1 
ATOM   1327 C CB  . THR A 1 169 ? 35.71900 -13.38700 -13.78000 1.000 44.82988 ? 169 THR A CB  1 
ATOM   1328 O OG1 . THR A 1 169 ? 35.10000 -14.49800 -14.44200 1.000 47.13721 ? 169 THR A OG1 1 
ATOM   1329 C CG2 . THR A 1 169 ? 36.10900 -12.33300 -14.80900 1.000 36.29138 ? 169 THR A CG2 1 
ATOM   1330 N N   . GLY A 1 170 ? 36.92800 -15.90100 -11.62000 1.000 39.72899 ? 170 GLY A N   1 
ATOM   1331 C CA  . GLY A 1 170 ? 36.52700 -16.71400 -10.49400 1.000 38.88459 ? 170 GLY A CA  1 
ATOM   1332 C C   . GLY A 1 170 ? 35.30400 -17.57400 -10.72400 1.000 35.95853 ? 170 GLY A C   1 
ATOM   1333 O O   . GLY A 1 170 ? 35.01800 -18.44500 -9.89200  1.000 38.45509 ? 170 GLY A O   1 
ATOM   1334 N N   . VAL A 1 171 ? 34.56800 -17.35600 -11.81500 1.000 40.27481 ? 171 VAL A N   1 
ATOM   1335 C CA  . VAL A 1 171 ? 33.43600 -18.21400 -12.14600 1.000 32.90783 ? 171 VAL A CA  1 
ATOM   1336 C C   . VAL A 1 171 ? 33.94000 -19.49500 -12.80600 1.000 38.86709 ? 171 VAL A C   1 
ATOM   1337 O O   . VAL A 1 171 ? 35.08300 -19.58700 -13.26700 1.000 36.03450 ? 171 VAL A O   1 
ATOM   1338 C CB  . VAL A 1 171 ? 32.42700 -17.48200 -13.04800 1.000 36.96800 ? 171 VAL A CB  1 
ATOM   1339 C CG1 . VAL A 1 171 ? 31.96600 -16.18800 -12.39400 1.000 35.59262 ? 171 VAL A CG1 1 
ATOM   1340 C CG2 . VAL A 1 171 ? 33.03900 -17.21200 -14.41400 1.000 35.58074 ? 171 VAL A CG2 1 
ATOM   1341 N N   . HIS A 1 172 ? 33.06400 -20.49300 -12.86900 1.000 35.49332 ? 172 HIS A N   1 
ATOM   1342 C CA  . HIS A 1 172 ? 33.44300 -21.83000 -13.29400 1.000 35.34590 ? 172 HIS A CA  1 
ATOM   1343 C C   . HIS A 1 172 ? 32.77900 -22.20300 -14.61300 1.000 32.51301 ? 172 HIS A C   1 
ATOM   1344 O O   . HIS A 1 172 ? 31.73900 -21.65900 -14.99200 1.000 34.87576 ? 172 HIS A O   1 
ATOM   1345 C CB  . HIS A 1 172 ? 33.09000 -22.85000 -12.20900 1.000 32.62614 ? 172 HIS A CB  1 
ATOM   1346 C CG  . HIS A 1 172 ? 33.66100 -22.50600 -10.87100 1.000 38.72558 ? 172 HIS A CG  1 
ATOM   1347 N ND1 . HIS A 1 172 ? 32.99500 -21.71900 -9.95700  1.000 41.21808 ? 172 HIS A ND1 1 
ATOM   1348 C CD2 . HIS A 1 172 ? 34.85300 -22.81200 -10.30500 1.000 37.44916 ? 172 HIS A CD2 1 
ATOM   1349 C CE1 . HIS A 1 172 ? 33.74300 -21.57000 -8.87900  1.000 39.08251 ? 172 HIS A CE1 1 
ATOM   1350 N NE2 . HIS A 1 172 ? 34.87500 -22.22600 -9.06400  1.000 39.60518 ? 172 HIS A NE2 1 
ATOM   1351 N N   . ALA A 1 173 ? 33.40700 -23.14700 -15.31200 1.000 30.23126 ? 173 ALA A N   1 
ATOM   1352 C CA  . ALA A 1 173 ? 32.94900 -23.59100 -16.61800 1.000 30.56413 ? 173 ALA A CA  1 
ATOM   1353 C C   . ALA A 1 173 ? 33.03800 -25.10800 -16.69300 1.000 30.36818 ? 173 ALA A C   1 
ATOM   1354 O O   . ALA A 1 173 ? 33.93300 -25.72200 -16.10800 1.000 34.16304 ? 173 ALA A O   1 
ATOM   1355 C CB  . ALA A 1 173 ? 33.77100 -22.95900 -17.74900 1.000 29.50628 ? 173 ALA A CB  1 
ATOM   1356 N N   . GLY A 1 174 ? 32.10400 -25.70600 -17.42100 1.000 31.61497 ? 174 GLY A N   1 
ATOM   1357 C CA  . GLY A 1 174 ? 32.05800 -27.14600 -17.52700 1.000 30.03805 ? 174 GLY A CA  1 
ATOM   1358 C C   . GLY A 1 174 ? 31.22300 -27.59200 -18.70800 1.000 28.43903 ? 174 GLY A C   1 
ATOM   1359 O O   . GLY A 1 174 ? 30.81700 -26.78600 -19.54700 1.000 26.24849 ? 174 GLY A O   1 
ATOM   1360 N N   . THR A 1 175 ? 30.97000 -28.89600 -18.76000 1.000 23.43587 ? 175 THR A N   1 
ATOM   1361 C CA  . THR A 1 175 ? 30.30900 -29.52300 -19.89400 1.000 28.04070 ? 175 THR A CA  1 
ATOM   1362 C C   . THR A 1 175 ? 29.04500 -30.23900 -19.44200 1.000 28.95467 ? 175 THR A C   1 
ATOM   1363 O O   . THR A 1 175 ? 28.78000 -30.39200 -18.24600 1.000 31.04920 ? 175 THR A O   1 
ATOM   1364 C CB  . THR A 1 175 ? 31.23200 -30.53300 -20.59100 1.000 25.56075 ? 175 THR A CB  1 
ATOM   1365 O OG1 . THR A 1 175 ? 31.41700 -31.66500 -19.73500 1.000 23.30785 ? 175 THR A OG1 1 
ATOM   1366 C CG2 . THR A 1 175 ? 32.58200 -29.91300 -20.90000 1.000 22.50067 ? 175 THR A CG2 1 
ATOM   1367 N N   . ASP A 1 176 ? 28.26100 -30.67800 -20.42600 1.000 25.56211 ? 176 ASP A N   1 
ATOM   1368 C CA  . ASP A 1 176 ? 27.23100 -31.67000 -20.17200 1.000 26.00872 ? 176 ASP A CA  1 
ATOM   1369 C C   . ASP A 1 176 ? 27.88700 -33.04600 -20.05700 1.000 24.93317 ? 176 ASP A C   1 
ATOM   1370 O O   . ASP A 1 176 ? 29.10500 -33.19200 -20.19200 1.000 22.83435 ? 176 ASP A O   1 
ATOM   1371 C CB  . ASP A 1 176 ? 26.15800 -31.62100 -21.26200 1.000 29.47651 ? 176 ASP A CB  1 
ATOM   1372 C CG  . ASP A 1 176 ? 26.70400 -31.88900 -22.66600 1.000 28.97171 ? 176 ASP A CG  1 
ATOM   1373 O OD1 . ASP A 1 176 ? 27.70100 -32.62300 -22.82000 1.000 23.96837 ? 176 ASP A OD1 1 
ATOM   1374 O OD2 . ASP A 1 176 ? 26.11700 -31.35900 -23.63200 1.000 35.12493 ? 176 ASP A OD2 1 
ATOM   1375 N N   . LEU A 1 177 ? 27.08100 -34.07800 -19.82600 1.000 25.67911 ? 177 LEU A N   1 
ATOM   1376 C CA  . LEU A 1 177 ? 27.64700 -35.41400 -19.68300 1.000 28.78880 ? 177 LEU A CA  1 
ATOM   1377 C C   . LEU A 1 177 ? 28.02200 -36.04900 -21.01600 1.000 32.28888 ? 177 LEU A C   1 
ATOM   1378 O O   . LEU A 1 177 ? 28.53700 -37.17300 -21.02500 1.000 31.07739 ? 177 LEU A O   1 
ATOM   1379 C CB  . LEU A 1 177 ? 26.68700 -36.32200 -18.91400 1.000 24.10623 ? 177 LEU A CB  1 
ATOM   1380 C CG  . LEU A 1 177 ? 27.05400 -36.43500 -17.43200 1.000 28.38785 ? 177 LEU A CG  1 
ATOM   1381 C CD1 . LEU A 1 177 ? 28.44200 -37.03000 -17.28800 1.000 25.63482 ? 177 LEU A CD1 1 
ATOM   1382 C CD2 . LEU A 1 177 ? 26.99300 -35.07500 -16.74400 1.000 25.78055 ? 177 LEU A CD2 1 
ATOM   1383 N N   . GLU A 1 178 ? 27.79000 -35.36300 -22.13200 1.000 34.30975 ? 178 GLU A N   1 
ATOM   1384 C CA  . GLU A 1 178 ? 28.30700 -35.78100 -23.42600 1.000 30.43739 ? 178 GLU A CA  1 
ATOM   1385 C C   . GLU A 1 178 ? 29.60800 -35.07800 -23.78500 1.000 29.26325 ? 178 GLU A C   1 
ATOM   1386 O O   . GLU A 1 178 ? 30.12500 -35.28300 -24.88700 1.000 31.97911 ? 178 GLU A O   1 
ATOM   1387 C CB  . GLU A 1 178 ? 27.26900 -35.53300 -24.52300 1.000 28.04539 ? 178 GLU A CB  1 
ATOM   1388 C CG  . GLU A 1 178 ? 26.00800 -36.35600 -24.37400 1.000 38.26627 ? 178 GLU A CG  1 
ATOM   1389 C CD  . GLU A 1 178 ? 25.05300 -36.16000 -25.53200 1.000 46.10849 ? 178 GLU A CD  1 
ATOM   1390 O OE1 . GLU A 1 178 ? 25.49700 -35.67700 -26.59600 1.000 51.71951 ? 178 GLU A OE1 1 
ATOM   1391 O OE2 . GLU A 1 178 ? 23.85700 -36.48300 -25.37800 1.000 57.97816 ? 178 GLU A OE2 1 
ATOM   1392 N N   . GLY A 1 179 ? 30.13800 -34.24700 -22.89100 1.000 29.17837 ? 179 GLY A N   1 
ATOM   1393 C CA  . GLY A 1 179 ? 31.41100 -33.59400 -23.10300 1.000 28.77138 ? 179 GLY A CA  1 
ATOM   1394 C C   . GLY A 1 179 ? 31.35300 -32.25500 -23.80400 1.000 25.38726 ? 179 GLY A C   1 
ATOM   1395 O O   . GLY A 1 179 ? 32.40400 -31.63100 -23.99500 1.000 30.73218 ? 179 GLY A O   1 
ATOM   1396 N N   . ASN A 1 180 ? 30.17600 -31.79100 -24.19800 1.000 28.08136 ? 180 ASN A N   1 
ATOM   1397 C CA  . ASN A 1 180 ? 30.06100 -30.50300 -24.86900 1.000 28.72285 ? 180 ASN A CA  1 
ATOM   1398 C C   . ASN A 1 180 ? 30.05400 -29.39100 -23.83200 1.000 27.42380 ? 180 ASN A C   1 
ATOM   1399 O O   . ASN A 1 180 ? 29.19400 -29.36400 -22.94600 1.000 28.06243 ? 180 ASN A O   1 
ATOM   1400 C CB  . ASN A 1 180 ? 28.79700 -30.45100 -25.72100 1.000 31.10259 ? 180 ASN A CB  1 
ATOM   1401 C CG  . ASN A 1 180 ? 28.75900 -31.54600 -26.75800 1.000 35.91776 ? 180 ASN A CG  1 
ATOM   1402 O OD1 . ASN A 1 180 ? 29.57200 -31.56400 -27.68100 1.000 34.37180 ? 180 ASN A OD1 1 
ATOM   1403 N ND2 . ASN A 1 180 ? 27.81500 -32.47200 -26.61100 1.000 34.73712 ? 180 ASN A ND2 1 
ATOM   1404 N N   . PHE A 1 181 ? 31.01300 -28.47800 -23.94500 1.000 26.23013 ? 181 PHE A N   1 
ATOM   1405 C CA  . PHE A 1 181 ? 31.07800 -27.34500 -23.03600 1.000 27.40114 ? 181 PHE A CA  1 
ATOM   1406 C C   . PHE A 1 181 ? 29.82100 -26.49900 -23.13700 1.000 29.00045 ? 181 PHE A C   1 
ATOM   1407 O O   . PHE A 1 181 ? 29.26700 -26.30200 -24.22300 1.000 33.65810 ? 181 PHE A O   1 
ATOM   1408 C CB  . PHE A 1 181 ? 32.30200 -26.48100 -23.34400 1.000 28.87888 ? 181 PHE A CB  1 
ATOM   1409 C CG  . PHE A 1 181 ? 33.45100 -26.71100 -22.41300 1.000 31.78645 ? 181 PHE A CG  1 
ATOM   1410 C CD1 . PHE A 1 181 ? 33.48600 -26.09000 -21.17500 1.000 28.73997 ? 181 PHE A CD1 1 
ATOM   1411 C CD2 . PHE A 1 181 ? 34.49400 -27.55200 -22.77000 1.000 27.14701 ? 181 PHE A CD2 1 
ATOM   1412 C CE1 . PHE A 1 181 ? 34.54100 -26.30200 -20.30900 1.000 32.36794 ? 181 PHE A CE1 1 
ATOM   1413 C CE2 . PHE A 1 181 ? 35.55300 -27.76800 -21.91000 1.000 29.16013 ? 181 PHE A CE2 1 
ATOM   1414 C CZ  . PHE A 1 181 ? 35.57900 -27.14300 -20.67800 1.000 28.51367 ? 181 PHE A CZ  1 
ATOM   1415 N N   . TYR A 1 182 ? 29.35600 -26.02300 -21.98600 1.000 28.61460 ? 182 TYR A N   1 
ATOM   1416 C CA  . TYR A 1 182 ? 28.44000 -24.89700 -21.94200 1.000 29.40678 ? 182 TYR A CA  1 
ATOM   1417 C C   . TYR A 1 182 ? 29.24100 -23.62900 -22.20900 1.000 28.63835 ? 182 TYR A C   1 
ATOM   1418 O O   . TYR A 1 182 ? 30.16300 -23.30700 -21.45400 1.000 34.67780 ? 182 TYR A O   1 
ATOM   1419 C CB  . TYR A 1 182 ? 27.74200 -24.82100 -20.58700 1.000 32.59104 ? 182 TYR A CB  1 
ATOM   1420 C CG  . TYR A 1 182 ? 26.76200 -25.94300 -20.32600 1.000 36.07468 ? 182 TYR A CG  1 
ATOM   1421 C CD1 . TYR A 1 182 ? 25.43200 -25.83200 -20.70800 1.000 30.01620 ? 182 TYR A CD1 1 
ATOM   1422 C CD2 . TYR A 1 182 ? 27.16400 -27.10900 -19.68800 1.000 29.88109 ? 182 TYR A CD2 1 
ATOM   1423 C CE1 . TYR A 1 182 ? 24.53200 -26.85300 -20.46700 1.000 33.69439 ? 182 TYR A CE1 1 
ATOM   1424 C CE2 . TYR A 1 182 ? 26.27300 -28.13200 -19.44200 1.000 26.19091 ? 182 TYR A CE2 1 
ATOM   1425 C CZ  . TYR A 1 182 ? 24.96000 -28.00200 -19.83300 1.000 30.46419 ? 182 TYR A CZ  1 
ATOM   1426 O OH  . TYR A 1 182 ? 24.07200 -29.02700 -19.59100 1.000 22.73741 ? 182 TYR A OH  1 
ATOM   1427 N N   . GLY A 1 183 ? 28.91400 -22.92500 -23.28700 1.000 34.47188 ? 183 GLY A N   1 
ATOM   1428 C CA  . GLY A 1 183 ? 29.60000 -21.70000 -23.61900 1.000 30.88242 ? 183 GLY A CA  1 
ATOM   1429 C C   . GLY A 1 183 ? 30.74000 -21.90800 -24.59400 1.000 34.24676 ? 183 GLY A C   1 
ATOM   1430 O O   . GLY A 1 183 ? 30.99200 -23.02100 -25.06800 1.000 38.76625 ? 183 GLY A O   1 
ATOM   1431 N N   . PRO A 1 184 ? 31.46500 -20.83000 -24.90500 1.000 33.88491 ? 184 PRO A N   1 
ATOM   1432 C CA  . PRO A 1 184 ? 32.52100 -20.91400 -25.92100 1.000 38.85490 ? 184 PRO A CA  1 
ATOM   1433 C C   . PRO A 1 184 ? 33.86000 -21.32700 -25.33800 1.000 37.75492 ? 184 PRO A C   1 
ATOM   1434 O O   . PRO A 1 184 ? 34.90600 -20.83400 -25.76700 1.000 49.40536 ? 184 PRO A O   1 
ATOM   1435 C CB  . PRO A 1 184 ? 32.57700 -19.48400 -26.46200 1.000 34.40963 ? 184 PRO A CB  1 
ATOM   1436 C CG  . PRO A 1 184 ? 32.30500 -18.66200 -25.23500 1.000 39.79302 ? 184 PRO A CG  1 
ATOM   1437 C CD  . PRO A 1 184 ? 31.31800 -19.45800 -24.39000 1.000 35.08030 ? 184 PRO A CD  1 
ATOM   1438 N N   . PHE A 1 185 ? 33.84100 -22.22500 -24.36500 1.000 33.55464 ? 185 PHE A N   1 
ATOM   1439 C CA  . PHE A 1 185 ? 35.01900 -22.53800 -23.57700 1.000 32.71552 ? 185 PHE A CA  1 
ATOM   1440 C C   . PHE A 1 185 ? 35.69200 -23.81400 -24.07300 1.000 29.30066 ? 185 PHE A C   1 
ATOM   1441 O O   . PHE A 1 185 ? 35.04400 -24.71400 -24.61300 1.000 30.72643 ? 185 PHE A O   1 
ATOM   1442 C CB  . PHE A 1 185 ? 34.64000 -22.66800 -22.10100 1.000 32.86196 ? 185 PHE A CB  1 
ATOM   1443 C CG  . PHE A 1 185 ? 33.93400 -21.45900 -21.55500 1.000 31.18052 ? 185 PHE A CG  1 
ATOM   1444 C CD1 . PHE A 1 185 ? 34.59200 -20.24500 -21.45700 1.000 30.60082 ? 185 PHE A CD1 1 
ATOM   1445 C CD2 . PHE A 1 185 ? 32.61400 -21.53100 -21.15000 1.000 33.70518 ? 185 PHE A CD2 1 
ATOM   1446 C CE1 . PHE A 1 185 ? 33.94800 -19.12800 -20.96400 1.000 31.96819 ? 185 PHE A CE1 1 
ATOM   1447 C CE2 . PHE A 1 185 ? 31.96300 -20.41700 -20.65400 1.000 32.24959 ? 185 PHE A CE2 1 
ATOM   1448 C CZ  . PHE A 1 185 ? 32.63100 -19.21500 -20.56000 1.000 32.46444 ? 185 PHE A CZ  1 
ATOM   1449 N N   . VAL A 1 186 ? 37.01300 -23.87100 -23.90200 1.000 26.81268 ? 186 VAL A N   1 
ATOM   1450 C CA  . VAL A 1 186 ? 37.80600 -25.04200 -24.25400 1.000 31.78401 ? 186 VAL A CA  1 
ATOM   1451 C C   . VAL A 1 186 ? 38.60100 -25.47400 -23.03100 1.000 29.97688 ? 186 VAL A C   1 
ATOM   1452 O O   . VAL A 1 186 ? 38.93200 -24.65900 -22.16400 1.000 28.75058 ? 186 VAL A O   1 
ATOM   1453 C CB  . VAL A 1 186 ? 38.74500 -24.77200 -25.45400 1.000 33.74587 ? 186 VAL A CB  1 
ATOM   1454 C CG1 . VAL A 1 186 ? 37.93300 -24.52500 -26.71900 1.000 34.96695 ? 186 VAL A CG1 1 
ATOM   1455 C CG2 . VAL A 1 186 ? 39.66000 -23.58900 -25.16900 1.000 28.56221 ? 186 VAL A CG2 1 
ATOM   1456 N N   . ASP A 1 187 ? 38.90100 -26.77300 -22.95600 1.000 31.20066 ? 187 ASP A N   1 
ATOM   1457 C CA  . ASP A 1 187 ? 39.63600 -27.32300 -21.81500 1.000 29.74221 ? 187 ASP A CA  1 
ATOM   1458 C C   . ASP A 1 187 ? 41.13000 -27.14300 -22.06100 1.000 31.40703 ? 187 ASP A C   1 
ATOM   1459 O O   . ASP A 1 187 ? 41.86400 -28.07000 -22.41000 1.000 32.52341 ? 187 ASP A O   1 
ATOM   1460 C CB  . ASP A 1 187 ? 39.26400 -28.78200 -21.55900 1.000 28.21655 ? 187 ASP A CB  1 
ATOM   1461 C CG  . ASP A 1 187 ? 39.19100 -29.61500 -22.82300 1.000 28.49603 ? 187 ASP A CG  1 
ATOM   1462 O OD1 . ASP A 1 187 ? 39.31000 -29.06400 -23.93600 1.000 35.60843 ? 187 ASP A OD1 1 
ATOM   1463 O OD2 . ASP A 1 187 ? 39.00900 -30.84100 -22.69200 1.000 30.67233 ? 187 ASP A OD2 1 
ATOM   1464 N N   . ARG A 1 188 ? 41.57900 -25.90600 -21.85900 1.000 37.01248 ? 188 ARG A N   1 
ATOM   1465 C CA  . ARG A 1 188 ? 42.97100 -25.52200 -22.02200 1.000 33.70897 ? 188 ARG A CA  1 
ATOM   1466 C C   . ARG A 1 188 ? 43.26300 -24.38600 -21.05100 1.000 36.54190 ? 188 ARG A C   1 
ATOM   1467 O O   . ARG A 1 188 ? 42.41500 -23.51500 -20.84200 1.000 40.13367 ? 188 ARG A O   1 
ATOM   1468 C CB  . ARG A 1 188 ? 43.25900 -25.09800 -23.46900 1.000 37.65314 ? 188 ARG A CB  1 
ATOM   1469 C CG  . ARG A 1 188 ? 44.46100 -24.19800 -23.62000 1.000 49.73870 ? 188 ARG A CG  1 
ATOM   1470 C CD  . ARG A 1 188 ? 44.73900 -23.84100 -25.06600 1.000 46.11870 ? 188 ARG A CD  1 
ATOM   1471 N NE  . ARG A 1 188 ? 45.92300 -22.99600 -25.16200 1.000 54.53553 ? 188 ARG A NE  1 
ATOM   1472 C CZ  . ARG A 1 188 ? 46.48600 -22.61300 -26.29900 1.000 60.43905 ? 188 ARG A CZ  1 
ATOM   1473 N NH1 . ARG A 1 188 ? 46.00200 -22.99100 -27.47100 1.000 63.70469 ? 188 ARG A NH1 1 
ATOM   1474 N NH2 . ARG A 1 188 ? 47.56100 -21.83100 -26.25900 1.000 57.61315 ? 188 ARG A NH2 1 
ATOM   1475 N N   . GLN A 1 189 ? 44.45200 -24.40600 -20.44900 1.000 39.16452 ? 189 GLN A N   1 
ATOM   1476 C CA  . GLN A 1 189 ? 44.84400 -23.35500 -19.51600 1.000 40.05728 ? 189 GLN A CA  1 
ATOM   1477 C C   . GLN A 1 189 ? 45.18300 -22.07100 -20.26000 1.000 45.17119 ? 189 GLN A C   1 
ATOM   1478 O O   . GLN A 1 189 ? 46.34600 -21.82400 -20.59600 1.000 46.58639 ? 189 GLN A O   1 
ATOM   1479 C CB  . GLN A 1 189 ? 46.03300 -23.79900 -18.66000 1.000 41.85365 ? 189 GLN A CB  1 
ATOM   1480 C CG  . GLN A 1 189 ? 46.48500 -22.75800 -17.64400 1.000 47.94166 ? 189 GLN A CG  1 
ATOM   1481 C CD  . GLN A 1 189 ? 47.64500 -23.23700 -16.79200 1.000 51.98314 ? 189 GLN A CD  1 
ATOM   1482 O OE1 . GLN A 1 189 ? 47.73700 -24.41900 -16.46100 1.000 53.96602 ? 189 GLN A OE1 1 
ATOM   1483 N NE2 . GLN A 1 189 ? 48.54100 -22.32100 -16.43600 1.000 48.68902 ? 189 GLN A NE2 1 
ATOM   1484 N N   . THR A 1 190 ? 44.17300 -21.24800 -20.52600 1.000 45.91354 ? 190 THR A N   1 
ATOM   1485 C CA  . THR A 1 190 ? 44.38700 -19.96300 -21.17000 1.000 43.00410 ? 190 THR A CA  1 
ATOM   1486 C C   . THR A 1 190 ? 43.29000 -19.01100 -20.71900 1.000 45.85326 ? 190 THR A C   1 
ATOM   1487 O O   . THR A 1 190 ? 42.20000 -19.43800 -20.33000 1.000 49.76664 ? 190 THR A O   1 
ATOM   1488 C CB  . THR A 1 190 ? 44.40200 -20.08900 -22.69700 1.000 45.10121 ? 190 THR A CB  1 
ATOM   1489 O OG1 . THR A 1 190 ? 44.62200 -18.79900 -23.27900 1.000 51.47505 ? 190 THR A OG1 1 
ATOM   1490 C CG2 . THR A 1 190 ? 43.08300 -20.64800 -23.19900 1.000 43.62425 ? 190 THR A CG2 1 
ATOM   1491 N N   . ALA A 1 191 ? 43.59300 -17.71700 -20.75500 1.000 48.32949 ? 191 ALA A N   1 
ATOM   1492 C CA  . ALA A 1 191 ? 42.64000 -16.70500 -20.31100 1.000 44.25266 ? 191 ALA A CA  1 
ATOM   1493 C C   . ALA A 1 191 ? 41.44900 -16.68000 -21.26100 1.000 44.58572 ? 191 ALA A C   1 
ATOM   1494 O O   . ALA A 1 191 ? 41.57700 -16.24700 -22.41000 1.000 45.19466 ? 191 ALA A O   1 
ATOM   1495 C CB  . ALA A 1 191 ? 43.32300 -15.34300 -20.24500 1.000 42.16778 ? 191 ALA A CB  1 
ATOM   1496 N N   . GLN A 1 192 ? 40.29300 -17.14800 -20.79400 1.000 41.38596 ? 192 GLN A N   1 
ATOM   1497 C CA  . GLN A 1 192 ? 39.08500 -17.21000 -21.60700 1.000 44.96074 ? 192 GLN A CA  1 
ATOM   1498 C C   . GLN A 1 192 ? 38.03700 -16.26700 -21.03800 1.000 40.19346 ? 192 GLN A C   1 
ATOM   1499 O O   . GLN A 1 192 ? 37.85800 -16.19200 -19.81700 1.000 41.40704 ? 192 GLN A O   1 
ATOM   1500 C CB  . GLN A 1 192 ? 38.54500 -18.63700 -21.67600 1.000 33.30031 ? 192 GLN A CB  1 
ATOM   1501 C CG  . GLN A 1 192 ? 39.54400 -19.61700 -22.24500 1.000 36.58753 ? 192 GLN A CG  1 
ATOM   1502 C CD  . GLN A 1 192 ? 38.98200 -21.00800 -22.28900 1.000 36.08361 ? 192 GLN A CD  1 
ATOM   1503 O OE1 . GLN A 1 192 ? 37.84200 -21.20800 -22.70300 1.000 36.11506 ? 192 GLN A OE1 1 
ATOM   1504 N NE2 . GLN A 1 192 ? 39.76300 -21.97900 -21.83600 1.000 30.50963 ? 192 GLN A NE2 1 
ATOM   1505 N N   . ALA A 1 193 ? 37.35600 -15.55100 -21.92500 1.000 38.80621 ? 193 ALA A N   1 
ATOM   1506 C CA  . ALA A 1 193 ? 36.37400 -14.56100 -21.52600 1.000 39.22839 ? 193 ALA A CA  1 
ATOM   1507 C C   . ALA A 1 193 ? 34.97400 -15.14800 -21.55100 1.000 39.85273 ? 193 ALA A C   1 
ATOM   1508 O O   . ALA A 1 193 ? 34.60600 -15.88400 -22.47100 1.000 36.52762 ? 193 ALA A O   1 
ATOM   1509 C CB  . ALA A 1 193 ? 36.43800 -13.34600 -22.44700 1.000 42.19260 ? 193 ALA A CB  1 
ATOM   1510 N N   . ALA A 1 194 ? 34.17800 -14.77200 -20.56000 1.000 43.28560 ? 194 ALA A N   1 
ATOM   1511 C CA  . ALA A 1 194 ? 32.81600 -15.25700 -20.46200 1.000 36.67725 ? 194 ALA A CA  1 
ATOM   1512 C C   . ALA A 1 194 ? 31.79700 -14.27100 -21.00900 1.000 44.21074 ? 194 ALA A C   1 
ATOM   1513 O O   . ALA A 1 194 ? 30.64100 -14.65300 -21.22400 1.000 49.25343 ? 194 ALA A O   1 
ATOM   1514 C CB  . ALA A 1 194 ? 32.48700 -15.59000 -19.00500 1.000 40.00434 ? 194 ALA A CB  1 
ATOM   1515 N N   . GLY A 1 195 ? 32.19200 -13.02500 -21.25100 1.000 39.55231 ? 195 GLY A N   1 
ATOM   1516 C CA  . GLY A 1 195 ? 31.26800 -12.03500 -21.75800 1.000 44.18897 ? 195 GLY A CA  1 
ATOM   1517 C C   . GLY A 1 195 ? 30.36300 -11.47700 -20.67800 1.000 37.84565 ? 195 GLY A C   1 
ATOM   1518 O O   . GLY A 1 195 ? 30.37100 -11.90100 -19.52200 1.000 39.08178 ? 195 GLY A O   1 
ATOM   1519 N N   . THR A 1 196 ? 29.56400 -10.49000 -21.07900 1.000 32.02691 ? 196 THR A N   1 
ATOM   1520 C CA  . THR A 1 196 ? 28.66500 -9.81600  -20.15100 1.000 34.61061 ? 196 THR A CA  1 
ATOM   1521 C C   . THR A 1 196 ? 27.62800 -10.80200 -19.62900 1.000 36.35931 ? 196 THR A C   1 
ATOM   1522 O O   . THR A 1 196 ? 26.82800 -11.33900 -20.40100 1.000 37.61121 ? 196 THR A O   1 
ATOM   1523 C CB  . THR A 1 196 ? 27.98000 -8.63900  -20.84100 1.000 32.47960 ? 196 THR A CB  1 
ATOM   1524 O OG1 . THR A 1 196 ? 28.93100 -7.94200  -21.65300 1.000 46.88292 ? 196 THR A OG1 1 
ATOM   1525 C CG2 . THR A 1 196 ? 27.40900 -7.67800  -19.81200 1.000 37.51658 ? 196 THR A CG2 1 
ATOM   1526 N N   . ASP A 1 197 ? 27.64800 -11.05100 -18.32300 1.000 36.54331 ? 197 ASP A N   1 
ATOM   1527 C CA  . ASP A 1 197 ? 26.65000 -11.90000 -17.68900 1.000 37.75066 ? 197 ASP A CA  1 
ATOM   1528 C C   . ASP A 1 197 ? 25.44100 -11.05000 -17.32600 1.000 38.23251 ? 197 ASP A C   1 
ATOM   1529 O O   . ASP A 1 197 ? 25.55200 -10.10700 -16.53600 1.000 44.98324 ? 197 ASP A O   1 
ATOM   1530 C CB  . ASP A 1 197 ? 27.20600 -12.58400 -16.44200 1.000 38.11350 ? 197 ASP A CB  1 
ATOM   1531 C CG  . ASP A 1 197 ? 26.21700 -13.56400 -15.83300 1.000 44.18967 ? 197 ASP A CG  1 
ATOM   1532 O OD1 . ASP A 1 197 ? 25.31400 -14.03100 -16.56800 1.000 39.67947 ? 197 ASP A OD1 1 
ATOM   1533 O OD2 . ASP A 1 197 ? 26.33300 -13.86200 -14.62400 1.000 43.92668 ? 197 ASP A OD2 1 
ATOM   1534 N N   . THR A 1 198 ? 24.29500 -11.38000 -17.90100 1.000 41.16739 ? 198 THR A N   1 
ATOM   1535 C CA  . THR A 1 198 ? 23.06900 -10.66400 -17.60000 1.000 42.57763 ? 198 THR A CA  1 
ATOM   1536 C C   . THR A 1 198 ? 22.29600 -11.38200 -16.50000 1.000 40.76430 ? 198 THR A C   1 
ATOM   1537 O O   . THR A 1 198 ? 22.55400 -12.54400 -16.17700 1.000 34.60710 ? 198 THR A O   1 
ATOM   1538 C CB  . THR A 1 198 ? 22.20700 -10.52000 -18.85500 1.000 48.10211 ? 198 THR A CB  1 
ATOM   1539 O OG1 . THR A 1 198 ? 21.78300 -11.81400 -19.30100 1.000 49.33347 ? 198 THR A OG1 1 
ATOM   1540 C CG2 . THR A 1 198 ? 23.00500 -9.84100  -19.96500 1.000 40.41950 ? 198 THR A CG2 1 
ATOM   1541 N N   . THR A 1 199 ? 21.34800 -10.66100 -15.91300 1.000 37.16560 ? 199 THR A N   1 
ATOM   1542 C CA  . THR A 1 199 ? 20.52600 -11.19200 -14.83800 1.000 36.64759 ? 199 THR A CA  1 
ATOM   1543 C C   . THR A 1 199 ? 19.31900 -11.92100 -15.41800 1.000 39.37817 ? 199 THR A C   1 
ATOM   1544 O O   . THR A 1 199 ? 18.69000 -11.44900 -16.37000 1.000 37.23839 ? 199 THR A O   1 
ATOM   1545 C CB  . THR A 1 199 ? 20.07600 -10.06200 -13.90900 1.000 35.15747 ? 199 THR A CB  1 
ATOM   1546 O OG1 . THR A 1 199 ? 21.22600 -9.35000  -13.43200 1.000 36.33646 ? 199 THR A OG1 1 
ATOM   1547 C CG2 . THR A 1 199 ? 19.30200 -10.61400 -12.72300 1.000 28.48456 ? 199 THR A CG2 1 
ATOM   1548 N N   . ILE A 1 200 ? 19.01000 -13.08300 -14.84300 1.000 35.25581 ? 200 ILE A N   1 
ATOM   1549 C CA  . ILE A 1 200 ? 17.88300 -13.89800 -15.28300 1.000 33.58548 ? 200 ILE A CA  1 
ATOM   1550 C C   . ILE A 1 200 ? 16.59600 -13.24600 -14.80200 1.000 35.28480 ? 200 ILE A C   1 
ATOM   1551 O O   . ILE A 1 200 ? 16.16000 -13.47200 -13.66700 1.000 34.04423 ? 200 ILE A O   1 
ATOM   1552 C CB  . ILE A 1 200 ? 18.00300 -15.34200 -14.76500 1.000 31.93918 ? 200 ILE A CB  1 
ATOM   1553 C CG1 . ILE A 1 200 ? 19.42700 -15.85900 -14.96800 1.000 37.91101 ? 200 ILE A CG1 1 
ATOM   1554 C CG2 . ILE A 1 200 ? 17.00800 -16.25100 -15.47100 1.000 29.55952 ? 200 ILE A CG2 1 
ATOM   1555 C CD1 . ILE A 1 200 ? 19.72700 -17.13000 -14.20000 1.000 37.27507 ? 200 ILE A CD1 1 
ATOM   1556 N N   . THR A 1 201 ? 15.97300 -12.44700 -15.67400 1.000 36.53456 ? 201 THR A N   1 
ATOM   1557 C CA  . THR A 1 201 ? 14.84500 -11.61500 -15.26700 1.000 28.37722 ? 201 THR A CA  1 
ATOM   1558 C C   . THR A 1 201 ? 13.66500 -12.45100 -14.78500 1.000 31.14334 ? 201 THR A C   1 
ATOM   1559 O O   . THR A 1 201 ? 13.04000 -12.12200 -13.76900 1.000 29.82676 ? 201 THR A O   1 
ATOM   1560 C CB  . THR A 1 201 ? 14.42000 -10.72100 -16.42600 1.000 35.69136 ? 201 THR A CB  1 
ATOM   1561 O OG1 . THR A 1 201 ? 15.57700 -10.08900 -16.98700 1.000 33.78828 ? 201 THR A OG1 1 
ATOM   1562 C CG2 . THR A 1 201 ? 13.44800 -9.65900  -15.94000 1.000 35.96499 ? 201 THR A CG2 1 
ATOM   1563 N N   . VAL A 1 202 ? 13.33900 -13.53100 -15.49700 1.000 31.49203 ? 202 VAL A N   1 
ATOM   1564 C CA  . VAL A 1 202 ? 12.20400 -14.35200 -15.08900 1.000 30.73930 ? 202 VAL A CA  1 
ATOM   1565 C C   . VAL A 1 202 ? 12.44600 -14.95200 -13.70900 1.000 34.56497 ? 202 VAL A C   1 
ATOM   1566 O O   . VAL A 1 202 ? 11.50700 -15.11500 -12.91900 1.000 30.18976 ? 202 VAL A O   1 
ATOM   1567 C CB  . VAL A 1 202 ? 11.91100 -15.43400 -16.15300 1.000 31.27543 ? 202 VAL A CB  1 
ATOM   1568 C CG1 . VAL A 1 202 ? 13.06000 -16.43000 -16.26100 1.000 34.99621 ? 202 VAL A CG1 1 
ATOM   1569 C CG2 . VAL A 1 202 ? 10.60200 -16.14800 -15.84700 1.000 35.56991 ? 202 VAL A CG2 1 
ATOM   1570 N N   . ASN A 1 203 ? 13.70300 -15.26000 -13.38100 1.000 35.56991 ? 203 ASN A N   1 
ATOM   1571 C CA  . ASN A 1 203 ? 14.01000 -15.79800 -12.06000 1.000 32.81795 ? 203 ASN A CA  1 
ATOM   1572 C C   . ASN A 1 203 ? 13.81900 -14.74600 -10.97200 1.000 33.14116 ? 203 ASN A C   1 
ATOM   1573 O O   . ASN A 1 203 ? 13.32300 -15.05800 -9.88200  1.000 29.36810 ? 203 ASN A O   1 
ATOM   1574 C CB  . ASN A 1 203 ? 15.43700 -16.34000 -12.03400 1.000 36.26399 ? 203 ASN A CB  1 
ATOM   1575 C CG  . ASN A 1 203 ? 15.56700 -17.68400 -12.72300 1.000 34.50795 ? 203 ASN A CG  1 
ATOM   1576 O OD1 . ASN A 1 203 ? 14.60900 -18.20100 -13.29500 1.000 37.34647 ? 203 ASN A OD1 1 
ATOM   1577 N ND2 . ASN A 1 203 ? 16.76300 -18.25300 -12.67900 1.000 30.38230 ? 203 ASN A ND2 1 
ATOM   1578 N N   . VAL A 1 204 ? 14.21000 -13.49800 -11.24600 1.000 31.58383 ? 204 VAL A N   1 
ATOM   1579 C CA  . VAL A 1 204 ? 14.00400 -12.42300 -10.27700 1.000 33.59483 ? 204 VAL A CA  1 
ATOM   1580 C C   . VAL A 1 204 ? 12.51900 -12.24300 -9.98800  1.000 35.16909 ? 204 VAL A C   1 
ATOM   1581 O O   . VAL A 1 204 ? 12.10800 -12.11200 -8.82800  1.000 37.38175 ? 204 VAL A O   1 
ATOM   1582 C CB  . VAL A 1 204 ? 14.64000 -11.11400 -10.77800 1.000 32.82465 ? 204 VAL A CB  1 
ATOM   1583 C CG1 . VAL A 1 204 ? 14.17700 -9.94400  -9.92400  1.000 35.01565 ? 204 VAL A CG1 1 
ATOM   1584 C CG2 . VAL A 1 204 ? 16.15800 -11.21600 -10.76400 1.000 26.32650 ? 204 VAL A CG2 1 
ATOM   1585 N N   . LEU A 1 205 ? 11.69100 -12.24000 -11.03700 1.000 33.46077 ? 205 LEU A N   1 
ATOM   1586 C CA  . LEU A 1 205 ? 10.25300 -12.07600 -10.84600 1.000 32.60708 ? 205 LEU A CA  1 
ATOM   1587 C C   . LEU A 1 205 ? 9.66900  -13.22200 -10.03100 1.000 34.34051 ? 205 LEU A C   1 
ATOM   1588 O O   . LEU A 1 205 ? 8.83500  -13.00000 -9.14700  1.000 33.25707 ? 205 LEU A O   1 
ATOM   1589 C CB  . LEU A 1 205 ? 9.55400  -11.96400 -12.20200 1.000 29.40346 ? 205 LEU A CB  1 
ATOM   1590 C CG  . LEU A 1 205 ? 9.87000  -10.67800 -12.97000 1.000 36.49382 ? 205 LEU A CG  1 
ATOM   1591 C CD1 . LEU A 1 205 ? 9.42900  -10.78500 -14.41900 1.000 36.31218 ? 205 LEU A CD1 1 
ATOM   1592 C CD2 . LEU A 1 205 ? 9.20300  -9.48900  -12.29200 1.000 37.30374 ? 205 LEU A CD2 1 
ATOM   1593 N N   . ALA A 1 206 ? 10.10000 -14.45500 -10.31000 1.000 34.08610 ? 206 ALA A N   1 
ATOM   1594 C CA  . ALA A 1 206 ? 9.61900  -15.59500 -9.53700  1.000 31.18260 ? 206 ALA A CA  1 
ATOM   1595 C C   . ALA A 1 206 ? 10.04600 -15.49800 -8.08000  1.000 32.96765 ? 206 ALA A C   1 
ATOM   1596 O O   . ALA A 1 206 ? 9.32800  -15.96100 -7.18600  1.000 34.48264 ? 206 ALA A O   1 
ATOM   1597 C CB  . ALA A 1 206 ? 10.12300 -16.89900 -10.15200 1.000 29.67066 ? 206 ALA A CB  1 
ATOM   1598 N N   . TRP A 1 207 ? 11.21000 -14.90000 -7.82600  1.000 31.80371 ? 207 TRP A N   1 
ATOM   1599 C CA  . TRP A 1 207 ? 11.66600 -14.70300 -6.45600  1.000 32.05846 ? 207 TRP A CA  1 
ATOM   1600 C C   . TRP A 1 207 ? 10.81200 -13.66200 -5.74200  1.000 33.91297 ? 207 TRP A C   1 
ATOM   1601 O O   . TRP A 1 207 ? 10.48500 -13.82200 -4.55900  1.000 28.37069 ? 207 TRP A O   1 
ATOM   1602 C CB  . TRP A 1 207 ? 13.14300 -14.30800 -6.47700  1.000 33.30416 ? 207 TRP A CB  1 
ATOM   1603 C CG  . TRP A 1 207 ? 13.75300 -13.95800 -5.15900  1.000 32.83704 ? 207 TRP A CG  1 
ATOM   1604 C CD1 . TRP A 1 207 ? 14.07500 -14.81500 -4.14500  1.000 33.05010 ? 207 TRP A CD1 1 
ATOM   1605 C CD2 . TRP A 1 207 ? 14.16700 -12.65700 -4.73300  1.000 31.06397 ? 207 TRP A CD2 1 
ATOM   1606 N NE1 . TRP A 1 207 ? 14.64600 -14.12100 -3.10600  1.000 33.71598 ? 207 TRP A NE1 1 
ATOM   1607 C CE2 . TRP A 1 207 ? 14.71300 -12.79400 -3.44300  1.000 32.43219 ? 207 TRP A CE2 1 
ATOM   1608 C CE3 . TRP A 1 207 ? 14.12600 -11.38700 -5.31700  1.000 34.02730 ? 207 TRP A CE3 1 
ATOM   1609 C CZ2 . TRP A 1 207 ? 15.20800 -11.71000 -2.72600  1.000 33.59932 ? 207 TRP A CZ2 1 
ATOM   1610 C CZ3 . TRP A 1 207 ? 14.61700 -10.31200 -4.60200  1.000 33.15808 ? 207 TRP A CZ3 1 
ATOM   1611 C CH2 . TRP A 1 207 ? 15.15200 -10.48000 -3.32200  1.000 33.14804 ? 207 TRP A CH2 1 
ATOM   1612 N N   . LEU A 1 208 ? 10.42700 -12.59600 -6.45000  1.000 31.34976 ? 208 LEU A N   1 
ATOM   1613 C CA  . LEU A 1 208 ? 9.52000  -11.60900 -5.87300  1.000 31.45383 ? 208 LEU A CA  1 
ATOM   1614 C C   . LEU A 1 208 ? 8.15100  -12.20800 -5.58000  1.000 31.88522 ? 208 LEU A C   1 
ATOM   1615 O O   . LEU A 1 208 ? 7.49700  -11.80700 -4.61200  1.000 34.24673 ? 208 LEU A O   1 
ATOM   1616 C CB  . LEU A 1 208 ? 9.38900  -10.40900 -6.80900  1.000 32.25871 ? 208 LEU A CB  1 
ATOM   1617 C CG  . LEU A 1 208 ? 10.67500 -9.60200  -6.97000  1.000 34.15022 ? 208 LEU A CG  1 
ATOM   1618 C CD1 . LEU A 1 208 ? 10.50100 -8.51000  -8.00700  1.000 35.14256 ? 208 LEU A CD1 1 
ATOM   1619 C CD2 . LEU A 1 208 ? 11.08700 -9.01800  -5.62800  1.000 35.38486 ? 208 LEU A CD2 1 
ATOM   1620 N N   . TYR A 1 209 ? 7.70200  -13.16200 -6.39900  1.000 35.44077 ? 209 TYR A N   1 
ATOM   1621 C CA  . TYR A 1 209 ? 6.46000  -13.86300 -6.09400  1.000 30.51280 ? 209 TYR A CA  1 
ATOM   1622 C C   . TYR A 1 209 ? 6.59700  -14.70400 -4.83200  1.000 31.93769 ? 209 TYR A C   1 
ATOM   1623 O O   . TYR A 1 209 ? 5.65100  -14.80600 -4.04400  1.000 35.24680 ? 209 TYR A O   1 
ATOM   1624 C CB  . TYR A 1 209 ? 6.03800  -14.73600 -7.27500  1.000 35.28849 ? 209 TYR A CB  1 
ATOM   1625 C CG  . TYR A 1 209 ? 5.23000  -13.99900 -8.31400  1.000 39.31017 ? 209 TYR A CG  1 
ATOM   1626 C CD1 . TYR A 1 209 ? 3.89600  -13.67700 -8.08300  1.000 43.18299 ? 209 TYR A CD1 1 
ATOM   1627 C CD2 . TYR A 1 209 ? 5.79400  -13.62900 -9.52700  1.000 30.86295 ? 209 TYR A CD2 1 
ATOM   1628 C CE1 . TYR A 1 209 ? 3.15100  -13.00100 -9.02700  1.000 43.47020 ? 209 TYR A CE1 1 
ATOM   1629 C CE2 . TYR A 1 209 ? 5.05800  -12.95200 -10.47700 1.000 40.47603 ? 209 TYR A CE2 1 
ATOM   1630 C CZ  . TYR A 1 209 ? 3.73600  -12.64000 -10.22400 1.000 46.16927 ? 209 TYR A CZ  1 
ATOM   1631 O OH  . TYR A 1 209 ? 2.99600  -11.96900 -11.17000 1.000 44.35879 ? 209 TYR A OH  1 
ATOM   1632 N N   . ALA A 1 210 ? 7.76400  -15.32100 -4.62600  1.000 35.61654 ? 210 ALA A N   1 
ATOM   1633 C CA  . ALA A 1 210 ? 7.97600  -16.08700 -3.40200  1.000 37.29161 ? 210 ALA A CA  1 
ATOM   1634 C C   . ALA A 1 210 ? 8.00300  -15.18100 -2.18100  1.000 33.12479 ? 210 ALA A C   1 
ATOM   1635 O O   . ALA A 1 210 ? 7.60900  -15.60400 -1.08900  1.000 37.82685 ? 210 ALA A O   1 
ATOM   1636 C CB  . ALA A 1 210 ? 9.27400  -16.89100 -3.49300  1.000 34.83338 ? 210 ALA A CB  1 
ATOM   1637 N N   . ALA A 1 211 ? 8.45900  -13.93700 -2.35100  1.000 31.99302 ? 211 ALA A N   1 
ATOM   1638 C CA  . ALA A 1 211 ? 8.48200  -12.98900 -1.24300  1.000 36.13784 ? 211 ALA A CA  1 
ATOM   1639 C C   . ALA A 1 211 ? 7.07200  -12.62600 -0.79200  1.000 37.16022 ? 211 ALA A C   1 
ATOM   1640 O O   . ALA A 1 211 ? 6.79300  -12.58600 0.41200   1.000 42.89447 ? 211 ALA A O   1 
ATOM   1641 C CB  . ALA A 1 211 ? 9.25400  -11.73600 -1.65000  1.000 36.33175 ? 211 ALA A CB  1 
ATOM   1642 N N   . VAL A 1 212 ? 6.17500  -12.35200 -1.74200  1.000 35.12596 ? 212 VAL A N   1 
ATOM   1643 C CA  . VAL A 1 212 ? 4.79000  -12.04600 -1.39500  1.000 42.62088 ? 212 VAL A CA  1 
ATOM   1644 C C   . VAL A 1 212 ? 4.13700  -13.24000 -0.71000  1.000 42.58155 ? 212 VAL A C   1 
ATOM   1645 O O   . VAL A 1 212 ? 3.35700  -13.08300 0.23700   1.000 47.84544 ? 212 VAL A O   1 
ATOM   1646 C CB  . VAL A 1 212 ? 4.00900  -11.61400 -2.65200  1.000 38.14370 ? 212 VAL A CB  1 
ATOM   1647 C CG1 . VAL A 1 212 ? 2.55500  -11.32800 -2.30900  1.000 44.69217 ? 212 VAL A CG1 1 
ATOM   1648 C CG2 . VAL A 1 212 ? 4.65900  -10.40100 -3.28900  1.000 36.75979 ? 212 VAL A CG2 1 
ATOM   1649 N N   . ILE A 1 213 ? 4.44700  -14.45300 -1.17400  1.000 44.82311 ? 213 ILE A N   1 
ATOM   1650 C CA  . ILE A 1 213 ? 3.89700  -15.64900 -0.54600  1.000 39.50858 ? 213 ILE A CA  1 
ATOM   1651 C C   . ILE A 1 213 ? 4.36900  -15.76600 0.89500   1.000 40.93619 ? 213 ILE A C   1 
ATOM   1652 O O   . ILE A 1 213 ? 3.64600  -16.28800 1.74900   1.000 46.27813 ? 213 ILE A O   1 
ATOM   1653 C CB  . ILE A 1 213 ? 4.27000  -16.89800 -1.36600  1.000 39.28522 ? 213 ILE A CB  1 
ATOM   1654 C CG1 . ILE A 1 213 ? 3.65500  -16.82400 -2.76400  1.000 41.24065 ? 213 ILE A CG1 1 
ATOM   1655 C CG2 . ILE A 1 213 ? 3.82100  -18.16800 -0.66100  1.000 36.10108 ? 213 ILE A CG2 1 
ATOM   1656 C CD1 . ILE A 1 213 ? 4.09000  -17.95500 -3.68200  1.000 35.39244 ? 213 ILE A CD1 1 
ATOM   1657 N N   . ASN A 1 214 ? 5.56800  -15.27400 1.20000   1.000 39.07396 ? 214 ASN A N   1 
ATOM   1658 C CA  . ASN A 1 214 ? 6.12700  -15.40100 2.53800   1.000 41.59452 ? 214 ASN A CA  1 
ATOM   1659 C C   . ASN A 1 214 ? 5.89600  -14.17800 3.41400   1.000 38.50962 ? 214 ASN A C   1 
ATOM   1660 O O   . ASN A 1 214 ? 6.30400  -14.18500 4.57800   1.000 48.72883 ? 214 ASN A O   1 
ATOM   1661 C CB  . ASN A 1 214 ? 7.62500  -15.70200 2.45800   1.000 41.89861 ? 214 ASN A CB  1 
ATOM   1662 C CG  . ASN A 1 214 ? 7.90600  -17.17800 2.29000   1.000 46.36116 ? 214 ASN A CG  1 
ATOM   1663 O OD1 . ASN A 1 214 ? 8.07400  -17.90200 3.27200   1.000 50.64953 ? 214 ASN A OD1 1 
ATOM   1664 N ND2 . ASN A 1 214 ? 7.95100  -17.63800 1.04300   1.000 42.11826 ? 214 ASN A ND2 1 
ATOM   1665 N N   . GLY A 1 215 ? 5.31000  -13.12200 2.86300   1.000 42.28065 ? 215 GLY A N   1 
ATOM   1666 C CA  . GLY A 1 215 ? 4.97100  -11.94100 3.67800   1.000 43.71794 ? 215 GLY A CA  1 
ATOM   1667 C C   . GLY A 1 215 ? 5.71000  -10.66000 3.32100   1.000 47.11445 ? 215 GLY A C   1 
ATOM   1668 O O   . GLY A 1 215 ? 5.24700  -9.60300  3.75700   1.000 47.05944 ? 215 GLY A O   1 
ATOM   1669 N N   . ASP A 1 216 ? 6.82200  -10.73300 2.58400   1.000 46.81865 ? 216 ASP A N   1 
ATOM   1670 C CA  . ASP A 1 216 ? 7.52000  -9.49100  2.14400   1.000 46.60866 ? 216 ASP A CA  1 
ATOM   1671 C C   . ASP A 1 216 ? 6.72400  -8.86800  0.99400   1.000 48.22840 ? 216 ASP A C   1 
ATOM   1672 O O   . ASP A 1 216 ? 6.64600  -9.48300  -0.07200  1.000 44.49756 ? 216 ASP A O   1 
ATOM   1673 C CB  . ASP A 1 216 ? 9.00400  -9.72700  1.85600   1.000 41.95404 ? 216 ASP A CB  1 
ATOM   1674 C CG  . ASP A 1 216 ? 9.81900  -9.97300  3.11000   1.000 52.65526 ? 216 ASP A CG  1 
ATOM   1675 O OD1 . ASP A 1 216 ? 9.50400  -9.35000  4.13600   1.000 62.63283 ? 216 ASP A OD1 1 
ATOM   1676 O OD2 . ASP A 1 216 ? 10.75100 -10.79000 3.05100   1.000 53.28936 ? 216 ASP A OD2 1 
ATOM   1677 N N   . ARG A 1 217 ? 6.13600  -7.69000  1.23900   1.000 47.17490 ? 217 ARG A N   1 
ATOM   1678 C CA  . ARG A 1 217 ? 5.25600  -7.07000  0.22100   1.000 43.40836 ? 217 ARG A CA  1 
ATOM   1679 C C   . ARG A 1 217 ? 5.56400  -5.57800  0.09200   1.000 43.98091 ? 217 ARG A C   1 
ATOM   1680 O O   . ARG A 1 217 ? 4.90900  -4.92400  -0.71300  1.000 48.47597 ? 217 ARG A O   1 
ATOM   1681 C CB  . ARG A 1 217 ? 3.79900  -7.29200  0.62800   1.000 45.99754 ? 217 ARG A CB  1 
ATOM   1682 C CG  . ARG A 1 217 ? 3.25400  -8.67300  0.29800   1.000 52.09720 ? 217 ARG A CG  1 
ATOM   1683 C CD  . ARG A 1 217 ? 2.52800  -9.29300  1.47400   1.000 54.17022 ? 217 ARG A CD  1 
ATOM   1684 N NE  . ARG A 1 217 ? 1.71600  -10.44100 1.09900   1.000 57.36325 ? 217 ARG A NE  1 
ATOM   1685 C CZ  . ARG A 1 217 ? 1.33800  -11.39500 1.94000   1.000 55.24884 ? 217 ARG A CZ  1 
ATOM   1686 N NH1 . ARG A 1 217 ? 1.66400  -11.31600 3.21600   1.000 53.99156 ? 217 ARG A NH1 1 
ATOM   1687 N NH2 . ARG A 1 217 ? 0.64200  -12.42800 1.50100   1.000 52.80935 ? 217 ARG A NH2 1 
ATOM   1688 N N   . TRP A 1 218 ? 6.53000  -5.07100  0.84700   1.000 48.04704 ? 218 TRP A N   1 
ATOM   1689 C CA  . TRP A 1 218 ? 6.81200  -3.63900  0.80900   1.000 44.01597 ? 218 TRP A CA  1 
ATOM   1690 C C   . TRP A 1 218 ? 7.18500  -3.17100  -0.59300  1.000 44.64654 ? 218 TRP A C   1 
ATOM   1691 O O   . TRP A 1 218 ? 6.95100  -2.00800  -0.93900  1.000 54.39537 ? 218 TRP A O   1 
ATOM   1692 C CB  . TRP A 1 218 ? 7.91900  -3.29000  1.80800   1.000 44.07146 ? 218 TRP A CB  1 
ATOM   1693 C CG  . TRP A 1 218 ? 9.25900  -3.89800  1.50300   1.000 46.32993 ? 218 TRP A CG  1 
ATOM   1694 C CD1 . TRP A 1 218 ? 9.77200  -5.05500  2.01500   1.000 43.49090 ? 218 TRP A CD1 1 
ATOM   1695 C CD2 . TRP A 1 218 ? 10.26300 -3.36900  0.62800   1.000 44.29154 ? 218 TRP A CD2 1 
ATOM   1696 N NE1 . TRP A 1 218 ? 11.03000 -5.28200  1.50900   1.000 41.62020 ? 218 TRP A NE1 1 
ATOM   1697 C CE2 . TRP A 1 218 ? 11.35300 -4.26200  0.65400   1.000 45.19521 ? 218 TRP A CE2 1 
ATOM   1698 C CE3 . TRP A 1 218 ? 10.34500 -2.23000  -0.17700  1.000 46.22741 ? 218 TRP A CE3 1 
ATOM   1699 C CZ2 . TRP A 1 218 ? 12.51000 -4.05000  -0.09300  1.000 45.36649 ? 218 TRP A CZ2 1 
ATOM   1700 C CZ3 . TRP A 1 218 ? 11.49400 -2.02300  -0.91900  1.000 50.83488 ? 218 TRP A CZ3 1 
ATOM   1701 C CH2 . TRP A 1 218 ? 12.56000 -2.92900  -0.87200  1.000 43.29015 ? 218 TRP A CH2 1 
ATOM   1702 N N   . PHE A 1 219 ? 7.75100  -4.05300  -1.41600  1.000 45.15894 ? 219 PHE A N   1 
ATOM   1703 C CA  . PHE A 1 219 ? 8.13400  -3.67800  -2.77100  1.000 46.76492 ? 219 PHE A CA  1 
ATOM   1704 C C   . PHE A 1 219 ? 6.95000  -3.61500  -3.73100  1.000 46.84537 ? 219 PHE A C   1 
ATOM   1705 O O   . PHE A 1 219 ? 7.12500  -3.17600  -4.87200  1.000 43.60222 ? 219 PHE A O   1 
ATOM   1706 C CB  . PHE A 1 219 ? 9.18300  -4.65400  -3.31100  1.000 42.32754 ? 219 PHE A CB  1 
ATOM   1707 C CG  . PHE A 1 219 ? 8.73000  -6.08200  -3.31300  1.000 37.34136 ? 219 PHE A CG  1 
ATOM   1708 C CD1 . PHE A 1 219 ? 8.93900  -6.88700  -2.20800  1.000 36.16316 ? 219 PHE A CD1 1 
ATOM   1709 C CD2 . PHE A 1 219 ? 8.09100  -6.61800  -4.41900  1.000 41.88862 ? 219 PHE A CD2 1 
ATOM   1710 C CE1 . PHE A 1 219 ? 8.51600  -8.20100  -2.20400  1.000 41.72113 ? 219 PHE A CE1 1 
ATOM   1711 C CE2 . PHE A 1 219 ? 7.66600  -7.93300  -4.42300  1.000 39.79694 ? 219 PHE A CE2 1 
ATOM   1712 C CZ  . PHE A 1 219 ? 7.87700  -8.72500  -3.31400  1.000 37.49076 ? 219 PHE A CZ  1 
ATOM   1713 N N   . LEU A 1 220 ? 5.76400  -4.04700  -3.31000  1.000 43.41820 ? 220 LEU A N   1 
ATOM   1714 C CA  . LEU A 1 220 ? 4.58700  -3.95800  -4.16300  1.000 44.22226 ? 220 LEU A CA  1 
ATOM   1715 C C   . LEU A 1 220 ? 4.16400  -2.50100  -4.30100  1.000 53.39877 ? 220 LEU A C   1 
ATOM   1716 O O   . LEU A 1 220 ? 3.87400  -1.83200  -3.30300  1.000 54.28890 ? 220 LEU A O   1 
ATOM   1717 C CB  . LEU A 1 220 ? 3.44900  -4.79700  -3.58900  1.000 39.07346 ? 220 LEU A CB  1 
ATOM   1718 C CG  . LEU A 1 220 ? 3.61600  -6.31400  -3.68700  1.000 44.95518 ? 220 LEU A CG  1 
ATOM   1719 C CD1 . LEU A 1 220 ? 2.40900  -7.02500  -3.09600  1.000 41.69668 ? 220 LEU A CD1 1 
ATOM   1720 C CD2 . LEU A 1 220 ? 3.84100  -6.73800  -5.13000  1.000 39.61260 ? 220 LEU A CD2 1 
ATOM   1721 N N   . ASN A 1 221 ? 4.13000  -2.00900  -5.53100  1.000 54.52176 ? 221 ASN A N   1 
ATOM   1722 C CA  . ASN A 1 221 ? 3.78800  -0.62100  -5.77700  1.000 57.46446 ? 221 ASN A CA  1 
ATOM   1723 C C   . ASN A 1 221 ? 2.35700  -0.52700  -6.30800  1.000 53.81445 ? 221 ASN A C   1 
ATOM   1724 O O   . ASN A 1 221 ? 1.58800  -1.49300  -6.24900  1.000 55.50732 ? 221 ASN A O   1 
ATOM   1725 C CB  . ASN A 1 221 ? 4.81000  0.00400   -6.73700  1.000 53.78273 ? 221 ASN A CB  1 
ATOM   1726 C CG  . ASN A 1 221 ? 4.72600  -0.56700  -8.14900  1.000 59.22929 ? 221 ASN A CG  1 
ATOM   1727 O OD1 . ASN A 1 221 ? 3.92500  -1.46100  -8.43700  1.000 55.88783 ? 221 ASN A OD1 1 
ATOM   1728 N ND2 . ASN A 1 221 ? 5.55900  -0.04100  -9.04100  1.000 57.12923 ? 221 ASN A ND2 1 
ATOM   1729 N N   . ARG A 1 222 ? 2.00300  0.63500   -6.84600  1.000 57.00119 ? 222 ARG A N   1 
ATOM   1730 C CA  . ARG A 1 222 ? 0.68400  0.89200   -7.40100  1.000 59.22984 ? 222 ARG A CA  1 
ATOM   1731 C C   . ARG A 1 222 ? 0.78500  1.30800   -8.86600  1.000 58.71277 ? 222 ARG A C   1 
ATOM   1732 O O   . ARG A 1 222 ? -0.09500 1.99300   -9.39200  1.000 62.14641 ? 222 ARG A O   1 
ATOM   1733 C CB  . ARG A 1 222 ? -0.03800 1.94900   -6.56700  1.000 65.58442 ? 222 ARG A CB  1 
ATOM   1734 C CG  . ARG A 1 222 ? -0.12200 1.58500   -5.08500  1.000 70.54661 ? 222 ARG A CG  1 
ATOM   1735 C CD  . ARG A 1 222 ? -0.67000 2.71900   -4.22500  1.000 75.33818 ? 222 ARG A CD  1 
ATOM   1736 N NE  . ARG A 1 222 ? -2.08700 2.96000   -4.46700  1.000 70.52236 ? 222 ARG A NE  1 
ATOM   1737 C CZ  . ARG A 1 222 ? -2.85000 3.76200   -3.73600  1.000 74.73274 ? 222 ARG A CZ  1 
ATOM   1738 N NH1 . ARG A 1 222 ? -2.36800 4.40800   -2.68700  1.000 75.38927 ? 222 ARG A NH1 1 
ATOM   1739 N NH2 . ARG A 1 222 ? -4.13000 3.91700   -4.06600  1.000 75.09032 ? 222 ARG A NH2 1 
ATOM   1740 N N   . PHE A 1 223 ? 1.86400  0.89500   -9.52700  1.000 51.45581 ? 223 PHE A N   1 
ATOM   1741 C CA  . PHE A 1 223 ? 2.11200  1.15700   -10.93600 1.000 45.02456 ? 223 PHE A CA  1 
ATOM   1742 C C   . PHE A 1 223 ? 1.94800  -0.12100  -11.74500 1.000 45.64732 ? 223 PHE A C   1 
ATOM   1743 O O   . PHE A 1 223 ? 1.83200  -1.22400  -11.20400 1.000 52.06140 ? 223 PHE A O   1 
ATOM   1744 C CB  . PHE A 1 223 ? 3.52300  1.71500   -11.15500 1.000 52.18087 ? 223 PHE A CB  1 
ATOM   1745 C CG  . PHE A 1 223 ? 3.76900  3.03800   -10.49900 1.000 60.29373 ? 223 PHE A CG  1 
ATOM   1746 C CD1 . PHE A 1 223 ? 4.17200  3.10500   -9.17400  1.000 58.33316 ? 223 PHE A CD1 1 
ATOM   1747 C CD2 . PHE A 1 223 ? 3.61900  4.21600   -11.21200 1.000 63.92190 ? 223 PHE A CD2 1 
ATOM   1748 C CE1 . PHE A 1 223 ? 4.40500  4.32500   -8.56800  1.000 65.96916 ? 223 PHE A CE1 1 
ATOM   1749 C CE2 . PHE A 1 223 ? 3.85300  5.44000   -10.61400 1.000 64.24331 ? 223 PHE A CE2 1 
ATOM   1750 C CZ  . PHE A 1 223 ? 4.24600  5.49500   -9.28900  1.000 67.03241 ? 223 PHE A CZ  1 
ATOM   1751 N N   . THR A 1 224 ? 1.94900  0.04700   -13.06500 1.000 40.90213 ? 224 THR A N   1 
ATOM   1752 C CA  . THR A 1 224 ? 2.00100  -1.06300  -14.00500 1.000 42.46226 ? 224 THR A CA  1 
ATOM   1753 C C   . THR A 1 224 ? 2.90500  -0.65500  -15.16000 1.000 43.19960 ? 224 THR A C   1 
ATOM   1754 O O   . THR A 1 224 ? 3.42400  0.46500   -15.20100 1.000 40.46704 ? 224 THR A O   1 
ATOM   1755 C CB  . THR A 1 224 ? 0.60500  -1.45600  -14.49900 1.000 44.73610 ? 224 THR A CB  1 
ATOM   1756 O OG1 . THR A 1 224 ? 0.67500  -2.72800  -15.15800 1.000 46.96328 ? 224 THR A OG1 1 
ATOM   1757 C CG2 . THR A 1 224 ? 0.07100  -0.41300  -15.47000 1.000 36.41591 ? 224 THR A CG2 1 
ATOM   1758 N N   . THR A 1 225 ? 3.14700  -1.59100  -16.06900 1.000 44.24556 ? 225 THR A N   1 
ATOM   1759 C CA  . THR A 1 225 ? 4.06600  -1.28800  -17.19200 1.000 45.77943 ? 225 THR A CA  1 
ATOM   1760 C C   . THR A 1 225 ? 3.76700  -2.17000  -18.40300 1.000 46.49887 ? 225 THR A C   1 
ATOM   1761 O O   . THR A 1 225 ? 2.86700  -3.01400  -18.32000 1.000 44.76955 ? 225 THR A O   1 
ATOM   1762 C CB  . THR A 1 225 ? 5.53600  -1.44100  -16.77200 1.000 48.55489 ? 225 THR A CB  1 
ATOM   1763 O OG1 . THR A 1 225 ? 6.35500  -0.83700  -17.77300 1.000 55.10293 ? 225 THR A OG1 1 
ATOM   1764 C CG2 . THR A 1 225 ? 5.95100  -2.88100  -16.57300 1.000 50.91824 ? 225 THR A CG2 1 
ATOM   1765 N N   . THR A 1 226 ? 4.51300  -1.95400  -19.48100 1.000 50.08091 ? 226 THR A N   1 
ATOM   1766 C CA  . THR A 1 226 ? 4.37900  -2.78800  -20.69800 1.000 48.57075 ? 226 THR A CA  1 
ATOM   1767 C C   . THR A 1 226 ? 5.65600  -3.61300  -20.87100 1.000 45.67255 ? 226 THR A C   1 
ATOM   1768 O O   . THR A 1 226 ? 6.71400  -3.14800  -20.44400 1.000 47.54482 ? 226 THR A O   1 
ATOM   1769 C CB  . THR A 1 226 ? 4.12100  -1.91500  -21.92900 1.000 43.49943 ? 226 THR A CB  1 
ATOM   1770 O OG1 . THR A 1 226 ? 5.34800  -1.29000  -22.30000 1.000 45.00209 ? 226 THR A OG1 1 
ATOM   1771 C CG2 . THR A 1 226 ? 3.06100  -0.86500  -21.69500 1.000 46.46455 ? 226 THR A CG2 1 
ATOM   1772 N N   . LEU A 1 227 ? 5.54300  -4.78300  -21.48200 1.000 39.60438 ? 227 LEU A N   1 
ATOM   1773 C CA  . LEU A 1 227 ? 6.71300  -5.65300  -21.73500 1.000 43.02426 ? 227 LEU A CA  1 
ATOM   1774 C C   . LEU A 1 227 ? 7.82700  -4.82200  -22.36600 1.000 51.32392 ? 227 LEU A C   1 
ATOM   1775 O O   . LEU A 1 227 ? 8.97600  -4.96600  -21.94000 1.000 51.80928 ? 227 LEU A O   1 
ATOM   1776 C CB  . LEU A 1 227 ? 6.26700  -6.77300  -22.67800 1.000 39.46405 ? 227 LEU A CB  1 
ATOM   1777 C CG  . LEU A 1 227 ? 6.09300  -8.14500  -22.03100 1.000 45.72356 ? 227 LEU A CG  1 
ATOM   1778 C CD1 . LEU A 1 227 ? 6.10600  -9.24600  -23.07700 1.000 37.62053 ? 227 LEU A CD1 1 
ATOM   1779 C CD2 . LEU A 1 227 ? 7.17800  -8.38700  -20.99800 1.000 52.14099 ? 227 LEU A CD2 1 
ATOM   1780 N N   . ASN A 1 228 ? 7.47800  -3.96600  -23.32100 1.000 48.66784 ? 228 ASN A N   1 
ATOM   1781 C CA  . ASN A 1 228 ? 8.49900  -3.17900  -24.04700 1.000 47.44833 ? 228 ASN A CA  1 
ATOM   1782 C C   . ASN A 1 228 ? 9.11500  -2.13900  -23.11000 1.000 48.32809 ? 228 ASN A C   1 
ATOM   1783 O O   . ASN A 1 228 ? 10.33800 -1.96800  -23.14700 1.000 55.74488 ? 228 ASN A O   1 
ATOM   1784 C CB  . ASN A 1 228 ? 7.91900  -2.58900  -25.33500 1.000 46.27280 ? 228 ASN A CB  1 
ATOM   1785 C CG  . ASN A 1 228 ? 7.82900  -3.59600  -26.46400 1.000 52.51289 ? 228 ASN A CG  1 
ATOM   1786 O OD1 . ASN A 1 228 ? 8.19100  -4.75800  -26.30000 1.000 53.08363 ? 228 ASN A OD1 1 
ATOM   1787 N ND2 . ASN A 1 228 ? 7.35300  -3.16000  -27.61700 1.000 45.69095 ? 228 ASN A ND2 1 
ATOM   1788 N N   . ASP A 1 229 ? 8.30300  -1.47700  -22.30300 1.000 46.81992 ? 229 ASP A N   1 
ATOM   1789 C CA  . ASP A 1 229 ? 8.84900  -0.40300  -21.44100 1.000 54.77673 ? 229 ASP A CA  1 
ATOM   1790 C C   . ASP A 1 229 ? 9.68600  -1.04500  -20.33000 1.000 55.12913 ? 229 ASP A C   1 
ATOM   1791 O O   . ASP A 1 229 ? 10.72500 -0.47800  -19.96500 1.000 48.83033 ? 229 ASP A O   1 
ATOM   1792 C CB  . ASP A 1 229 ? 7.73500  0.53400   -20.96700 1.000 51.60018 ? 229 ASP A CB  1 
ATOM   1793 C CG  . ASP A 1 229 ? 7.23700  1.43600   -22.08300 1.000 65.54831 ? 229 ASP A CG  1 
ATOM   1794 O OD1 . ASP A 1 229 ? 7.80800  2.53100   -22.24500 1.000 63.79561 ? 229 ASP A OD1 1 
ATOM   1795 O OD2 . ASP A 1 229 ? 6.29200  1.03600   -22.79000 1.000 69.18853 ? 229 ASP A OD2 1 
ATOM   1796 N N   . PHE A 1 230 ? 9.25900  -2.20600  -19.83900 1.000 53.80001 ? 230 PHE A N   1 
ATOM   1797 C CA  . PHE A 1 230 ? 10.07300 -2.91700  -18.82400 1.000 54.78420 ? 230 PHE A CA  1 
ATOM   1798 C C   . PHE A 1 230 ? 11.41400 -3.31700  -19.44000 1.000 49.49581 ? 230 PHE A C   1 
ATOM   1799 O O   . PHE A 1 230 ? 12.44000 -3.09400  -18.81200 1.000 53.04411 ? 230 PHE A O   1 
ATOM   1800 C CB  . PHE A 1 230 ? 9.34600  -4.14500  -18.28300 1.000 46.40703 ? 230 PHE A CB  1 
ATOM   1801 C CG  . PHE A 1 230 ? 10.21700 -4.97700  -17.38500 1.000 52.89537 ? 230 PHE A CG  1 
ATOM   1802 C CD1 . PHE A 1 230 ? 10.59300 -4.50500  -16.14000 1.000 51.08894 ? 230 PHE A CD1 1 
ATOM   1803 C CD2 . PHE A 1 230 ? 10.70300 -6.20200  -17.80700 1.000 57.86262 ? 230 PHE A CD2 1 
ATOM   1804 C CE1 . PHE A 1 230 ? 11.42100 -5.25300  -15.32300 1.000 50.57697 ? 230 PHE A CE1 1 
ATOM   1805 C CE2 . PHE A 1 230 ? 11.53000 -6.94900  -16.98900 1.000 45.26414 ? 230 PHE A CE2 1 
ATOM   1806 C CZ  . PHE A 1 230 ? 11.88500 -6.47200  -15.75100 1.000 48.30200 ? 230 PHE A CZ  1 
ATOM   1807 N N   . ASN A 1 231 ? 11.38700 -3.86300  -20.65100 1.000 51.24759 ? 231 ASN A N   1 
ATOM   1808 C CA  . ASN A 1 231 ? 12.63500 -4.34600  -21.29400 1.000 50.37582 ? 231 ASN A CA  1 
ATOM   1809 C C   . ASN A 1 231 ? 13.52500 -3.14800  -21.62500 1.000 51.58696 ? 231 ASN A C   1 
ATOM   1810 O O   . ASN A 1 231 ? 14.73000 -3.35400  -21.76600 1.000 54.36897 ? 231 ASN A O   1 
ATOM   1811 C CB  . ASN A 1 231 ? 12.34800 -5.26600  -22.47900 1.000 49.95314 ? 231 ASN A CB  1 
ATOM   1812 C CG  . ASN A 1 231 ? 11.77000 -6.59800  -22.06200 1.000 50.19094 ? 231 ASN A CG  1 
ATOM   1813 O OD1 . ASN A 1 231 ? 11.90600 -7.00100  -20.91200 1.000 55.68678 ? 231 ASN A OD1 1 
ATOM   1814 N ND2 . ASN A 1 231 ? 11.12400 -7.28400  -22.98900 1.000 48.16491 ? 231 ASN A ND2 1 
ATOM   1815 N N   . LEU A 1 232 ? 12.96000 -1.94600  -21.71400 1.000 53.40883 ? 232 LEU A N   1 
ATOM   1816 C CA  . LEU A 1 232 ? 13.81500 -0.74500  -21.89200 1.000 52.83334 ? 232 LEU A CA  1 
ATOM   1817 C C   . LEU A 1 232 ? 14.62500 -0.55700  -20.60700 1.000 54.06414 ? 232 LEU A C   1 
ATOM   1818 O O   . LEU A 1 232 ? 15.81500 -0.22900  -20.71100 1.000 55.64857 ? 232 LEU A O   1 
ATOM   1819 C CB  . LEU A 1 232 ? 12.94100 0.47200   -22.18500 1.000 48.84280 ? 232 LEU A CB  1 
ATOM   1820 C CG  . LEU A 1 232 ? 12.17200 0.41700   -23.50100 1.000 60.37520 ? 232 LEU A CG  1 
ATOM   1821 C CD1 . LEU A 1 232 ? 11.23000 1.60400   -23.61600 1.000 60.48308 ? 232 LEU A CD1 1 
ATOM   1822 C CD2 . LEU A 1 232 ? 13.13200 0.38100   -24.67700 1.000 53.50472 ? 232 LEU A CD2 1 
ATOM   1823 N N   . VAL A 1 233 ? 14.00000 -0.77300  -19.44900 1.000 49.28862 ? 233 VAL A N   1 
ATOM   1824 C CA  . VAL A 1 233 ? 14.74000 -0.70800  -18.15600 1.000 51.96979 ? 233 VAL A CA  1 
ATOM   1825 C C   . VAL A 1 233 ? 15.63600 -1.93700  -18.03900 1.000 49.72952 ? 233 VAL A C   1 
ATOM   1826 O O   . VAL A 1 233 ? 16.75600 -1.80300  -17.54700 1.000 52.70464 ? 233 VAL A O   1 
ATOM   1827 C CB  . VAL A 1 233 ? 13.76900 -0.63500  -16.97000 1.000 53.77565 ? 233 VAL A CB  1 
ATOM   1828 C CG1 . VAL A 1 233 ? 14.47500 -0.29900  -15.66800 1.000 52.82090 ? 233 VAL A CG1 1 
ATOM   1829 C CG2 . VAL A 1 233 ? 12.65100 0.35500   -17.24700 1.000 58.84644 ? 233 VAL A CG2 1 
ATOM   1830 N N   . ALA A 1 234 ? 15.15100 -3.08300  -18.49500 1.000 45.63555 ? 234 ALA A N   1 
ATOM   1831 C CA  . ALA A 1 234 ? 15.92300 -4.31100  -18.33600 1.000 47.80500 ? 234 ALA A CA  1 
ATOM   1832 C C   . ALA A 1 234 ? 17.25200 -4.22400  -19.07600 1.000 48.87133 ? 234 ALA A C   1 
ATOM   1833 O O   . ALA A 1 234 ? 18.31400 -4.47700  -18.49700 1.000 47.91976 ? 234 ALA A O   1 
ATOM   1834 C CB  . ALA A 1 234 ? 15.10600 -5.50700  -18.82700 1.000 42.34911 ? 234 ALA A CB  1 
ATOM   1835 N N   . MET A 1 235 ? 17.20900 -3.85800  -20.36000 1.000 49.46458 ? 235 MET A N   1 
ATOM   1836 C CA  . MET A 1 235 ? 18.43000 -3.78400  -21.15600 1.000 50.63801 ? 235 MET A CA  1 
ATOM   1837 C C   . MET A 1 235 ? 19.43700 -2.81500  -20.54800 1.000 52.44808 ? 235 MET A C   1 
ATOM   1838 O O   . MET A 1 235 ? 20.64900 -3.05600  -20.59800 1.000 47.62209 ? 235 MET A O   1 
ATOM   1839 C CB  . MET A 1 235 ? 18.09200 -3.37900  -22.59000 1.000 61.94725 ? 235 MET A CB  1 
ATOM   1840 C CG  . MET A 1 235 ? 17.43600 -4.48500  -23.40200 1.000 67.48892 ? 235 MET A CG  1 
ATOM   1841 S SD  . MET A 1 235 ? 18.46300 -5.03900  -24.77800 1.000 91.71335 ? 235 MET A SD  1 
ATOM   1842 C CE  . MET A 1 235 ? 18.13700 -3.75500  -25.98700 1.000 75.53115 ? 235 MET A CE  1 
ATOM   1843 N N   . LYS A 1 236 ? 18.95600 -1.71400  -19.96400 1.000 51.17049 ? 236 LYS A N   1 
ATOM   1844 C CA  . LYS A 1 236 ? 19.86900 -0.75100  -19.35700 1.000 51.97317 ? 236 LYS A CA  1 
ATOM   1845 C C   . LYS A 1 236 ? 20.57400 -1.34700  -18.14500 1.000 47.50028 ? 236 LYS A C   1 
ATOM   1846 O O   . LYS A 1 236 ? 21.75200 -1.06100  -17.90300 1.000 50.74174 ? 236 LYS A O   1 
ATOM   1847 C CB  . LYS A 1 236 ? 19.11300 0.51700   -18.96200 1.000 52.76055 ? 236 LYS A CB  1 
ATOM   1848 C CG  . LYS A 1 236 ? 20.01900 1.66500   -18.54100 1.000 58.47794 ? 236 LYS A CG  1 
ATOM   1849 C CD  . LYS A 1 236 ? 19.57000 2.28300   -17.22400 1.000 57.93255 ? 236 LYS A CD  1 
ATOM   1850 C CE  . LYS A 1 236 ? 20.24800 3.62800   -16.99400 1.000 56.10073 ? 236 LYS A CE  1 
ATOM   1851 N NZ  . LYS A 1 236 ? 19.89400 4.22600   -15.67800 1.000 56.36861 ? 236 LYS A NZ  1 
ATOM   1852 N N   . TYR A 1 237 ? 19.87100 -2.17500  -17.37300 1.000 45.28765 ? 237 TYR A N   1 
ATOM   1853 C CA  . TYR A 1 237 ? 20.42300 -2.78600  -16.17300 1.000 51.83188 ? 237 TYR A CA  1 
ATOM   1854 C C   . TYR A 1 237 ? 20.95400 -4.19700  -16.42300 1.000 48.34307 ? 237 TYR A C   1 
ATOM   1855 O O   . TYR A 1 237 ? 21.10300 -4.97300  -15.47200 1.000 46.73436 ? 237 TYR A O   1 
ATOM   1856 C CB  . TYR A 1 237 ? 19.37400 -2.79000  -15.05900 1.000 44.77601 ? 237 TYR A CB  1 
ATOM   1857 C CG  . TYR A 1 237 ? 19.16200 -1.42800  -14.42700 1.000 49.68147 ? 237 TYR A CG  1 
ATOM   1858 C CD1 . TYR A 1 237 ? 19.97200 -0.99600  -13.38000 1.000 49.99535 ? 237 TYR A CD1 1 
ATOM   1859 C CD2 . TYR A 1 237 ? 18.16200 -0.57200  -14.87900 1.000 44.22345 ? 237 TYR A CD2 1 
ATOM   1860 C CE1 . TYR A 1 237 ? 19.79000 0.24400   -12.79800 1.000 48.85334 ? 237 TYR A CE1 1 
ATOM   1861 C CE2 . TYR A 1 237 ? 17.97200 0.67200   -14.30400 1.000 42.12691 ? 237 TYR A CE2 1 
ATOM   1862 C CZ  . TYR A 1 237 ? 18.78900 1.07400   -13.26300 1.000 51.35967 ? 237 TYR A CZ  1 
ATOM   1863 O OH  . TYR A 1 237 ? 18.61700 2.30800   -12.67900 1.000 46.73835 ? 237 TYR A OH  1 
ATOM   1864 N N   . ASN A 1 238 ? 21.25800 -4.53100  -17.67800 1.000 41.93658 ? 238 ASN A N   1 
ATOM   1865 C CA  . ASN A 1 238 ? 21.77700 -5.84600  -18.05600 1.000 43.13596 ? 238 ASN A CA  1 
ATOM   1866 C C   . ASN A 1 238 ? 20.88100 -6.96600  -17.53000 1.000 41.54407 ? 238 ASN A C   1 
ATOM   1867 O O   . ASN A 1 238 ? 21.32400 -7.87500  -16.82700 1.000 44.64961 ? 238 ASN A O   1 
ATOM   1868 C CB  . ASN A 1 238 ? 23.22000 -6.02800  -17.57900 1.000 49.14468 ? 238 ASN A CB  1 
ATOM   1869 C CG  . ASN A 1 238 ? 24.21500 -5.21700  -18.39400 1.000 53.39699 ? 238 ASN A CG  1 
ATOM   1870 O OD1 . ASN A 1 238 ? 23.97300 -4.90300  -19.56000 1.000 52.50037 ? 238 ASN A OD1 1 
ATOM   1871 N ND2 . ASN A 1 238 ? 25.34600 -4.88400  -17.78400 1.000 53.85790 ? 238 ASN A ND2 1 
ATOM   1872 N N   . TYR A 1 239 ? 19.60500 -6.87700  -17.88700 1.000 35.55326 ? 239 TYR A N   1 
ATOM   1873 C CA  . TYR A 1 239 ? 18.63600 -7.91700  -17.49300 1.000 33.19028 ? 239 TYR A CA  1 
ATOM   1874 C C   . TYR A 1 239 ? 18.13600 -8.60600  -18.75900 1.000 35.48649 ? 239 TYR A C   1 
ATOM   1875 O O   . TYR A 1 239 ? 18.08600 -7.96600  -19.80800 1.000 35.48019 ? 239 TYR A O   1 
ATOM   1876 C CB  . TYR A 1 239 ? 17.47000 -7.31100  -16.72100 1.000 39.66201 ? 239 TYR A CB  1 
ATOM   1877 C CG  . TYR A 1 239 ? 17.53800 -7.38600  -15.22000 1.000 36.35893 ? 239 TYR A CG  1 
ATOM   1878 C CD1 . TYR A 1 239 ? 18.52000 -6.71600  -14.51600 1.000 35.46100 ? 239 TYR A CD1 1 
ATOM   1879 C CD2 . TYR A 1 239 ? 16.59100 -8.09300  -14.50400 1.000 28.23366 ? 239 TYR A CD2 1 
ATOM   1880 C CE1 . TYR A 1 239 ? 18.57700 -6.76800  -13.13600 1.000 33.12612 ? 239 TYR A CE1 1 
ATOM   1881 C CE2 . TYR A 1 239 ? 16.63000 -8.15300  -13.12300 1.000 34.17429 ? 239 TYR A CE2 1 
ATOM   1882 C CZ  . TYR A 1 239 ? 17.62800 -7.48800  -12.43700 1.000 30.96519 ? 239 TYR A CZ  1 
ATOM   1883 O OH  . TYR A 1 239 ? 17.68400 -7.54400  -11.07400 1.000 31.44267 ? 239 TYR A OH  1 
ATOM   1884 N N   . GLU A 1 240 ? 17.80500 -9.88500  -18.65100 1.000 39.41834 ? 240 GLU A N   1 
ATOM   1885 C CA  . GLU A 1 240 ? 17.30100 -10.66600 -19.80600 1.000 41.14949 ? 240 GLU A CA  1 
ATOM   1886 C C   . GLU A 1 240 ? 15.99100 -10.06200 -20.29900 1.000 41.23421 ? 240 GLU A C   1 
ATOM   1887 O O   . GLU A 1 240 ? 15.14200 -9.71600  -19.48400 1.000 44.36220 ? 240 GLU A O   1 
ATOM   1888 C CB  . GLU A 1 240 ? 17.03000 -12.10700 -19.39500 1.000 42.35045 ? 240 GLU A CB  1 
ATOM   1889 C CG  . GLU A 1 240 ? 18.19900 -13.04700 -19.57300 1.000 47.37545 ? 240 GLU A CG  1 
ATOM   1890 C CD  . GLU A 1 240 ? 17.83700 -14.46300 -19.16900 1.000 55.01615 ? 240 GLU A CD  1 
ATOM   1891 O OE1 . GLU A 1 240 ? 16.63400 -14.74400 -19.02300 1.000 48.86592 ? 240 GLU A OE1 1 
ATOM   1892 O OE2 . GLU A 1 240 ? 18.75300 -15.27800 -18.99800 1.000 57.79806 ? 240 GLU A OE2 1 
ATOM   1893 N N   . PRO A 1 241 ? 15.79900 -9.92000  -21.61600 1.000 42.58942 ? 241 PRO A N   1 
ATOM   1894 C CA  . PRO A 1 241 ? 14.54300 -9.40700  -22.12000 1.000 43.69972 ? 241 PRO A CA  1 
ATOM   1895 C C   . PRO A 1 241 ? 13.40100 -10.37400 -21.77700 1.000 48.73866 ? 241 PRO A C   1 
ATOM   1896 O O   . PRO A 1 241 ? 13.55300 -11.54900 -21.99000 1.000 49.65649 ? 241 PRO A O   1 
ATOM   1897 C CB  . PRO A 1 241 ? 14.80900 -9.28900  -23.62400 1.000 45.49395 ? 241 PRO A CB  1 
ATOM   1898 C CG  . PRO A 1 241 ? 16.31400 -9.24600  -23.73700 1.000 46.10169 ? 241 PRO A CG  1 
ATOM   1899 C CD  . PRO A 1 241 ? 16.78600 -10.18700 -22.65400 1.000 44.15656 ? 241 PRO A CD  1 
ATOM   1900 N N   . LEU A 1 242 ? 12.30700 -9.84900  -21.23100 1.000 47.38536 ? 242 LEU A N   1 
ATOM   1901 C CA  . LEU A 1 242 ? 11.16300 -10.66800 -20.86200 1.000 46.67133 ? 242 LEU A CA  1 
ATOM   1902 C C   . LEU A 1 242 ? 10.30400 -10.92200 -22.09300 1.000 47.21138 ? 242 LEU A C   1 
ATOM   1903 O O   . LEU A 1 242 ? 10.04900 -10.00600 -22.88100 1.000 52.47509 ? 242 LEU A O   1 
ATOM   1904 C CB  . LEU A 1 242 ? 10.34600 -9.98500  -19.76400 1.000 44.89753 ? 242 LEU A CB  1 
ATOM   1905 C CG  . LEU A 1 242 ? 9.54000  -10.91000 -18.85000 1.000 48.35915 ? 242 LEU A CG  1 
ATOM   1906 C CD1 . LEU A 1 242 ? 10.46200 -11.65000 -17.88800 1.000 43.49582 ? 242 LEU A CD1 1 
ATOM   1907 C CD2 . LEU A 1 242 ? 8.47300  -10.14200 -18.09300 1.000 45.86295 ? 242 LEU A CD2 1 
ATOM   1908 N N   . THR A 1 243 ? 9.87500  -12.16800 -22.26500 1.000 50.95286 ? 243 THR A N   1 
ATOM   1909 C CA  . THR A 1 243 ? 9.06200  -12.57900 -23.39800 1.000 44.49491 ? 243 THR A CA  1 
ATOM   1910 C C   . THR A 1 243 ? 7.71800  -13.09800 -22.90800 1.000 48.57621 ? 243 THR A C   1 
ATOM   1911 O O   . THR A 1 243 ? 7.48800  -13.27200 -21.70900 1.000 51.12856 ? 243 THR A O   1 
ATOM   1912 C CB  . THR A 1 243 ? 9.76800  -13.66100 -24.22500 1.000 43.55957 ? 243 THR A CB  1 
ATOM   1913 O OG1 . THR A 1 243 ? 9.82500  -14.87700 -23.47000 1.000 48.38589 ? 243 THR A OG1 1 
ATOM   1914 C CG2 . THR A 1 243 ? 11.18100 -13.22600 -24.57500 1.000 45.72658 ? 243 THR A CG2 1 
ATOM   1915 N N   . GLN A 1 244 ? 6.82000  -13.34700 -23.86400 1.000 51.71563 ? 244 GLN A N   1 
ATOM   1916 C CA  . GLN A 1 244 ? 5.51600  -13.90200 -23.52100 1.000 47.64366 ? 244 GLN A CA  1 
ATOM   1917 C C   . GLN A 1 244 ? 5.64300  -15.30600 -22.94300 1.000 50.12159 ? 244 GLN A C   1 
ATOM   1918 O O   . GLN A 1 244 ? 4.84800  -15.69600 -22.07900 1.000 46.27490 ? 244 GLN A O   1 
ATOM   1919 C CB  . GLN A 1 244 ? 4.60700  -13.90200 -24.75100 1.000 46.29125 ? 244 GLN A CB  1 
ATOM   1920 C CG  . GLN A 1 244 ? 3.18600  -14.36000 -24.46700 1.000 49.13794 ? 244 GLN A CG  1 
ATOM   1921 C CD  . GLN A 1 244 ? 2.54000  -13.58100 -23.33800 1.000 48.92684 ? 244 GLN A CD  1 
ATOM   1922 O OE1 . GLN A 1 244 ? 2.63400  -12.35400 -23.28200 1.000 49.89921 ? 244 GLN A OE1 1 
ATOM   1923 N NE2 . GLN A 1 244 ? 1.88500  -14.29300 -22.42600 1.000 47.24410 ? 244 GLN A NE2 1 
ATOM   1924 N N   . ASP A 1 245 ? 6.63200  -16.07800 -23.40200 1.000 45.80882 ? 245 ASP A N   1 
ATOM   1925 C CA  . ASP A 1 245 ? 6.91500  -17.35800 -22.76200 1.000 47.33084 ? 245 ASP A CA  1 
ATOM   1926 C C   . ASP A 1 245 ? 7.25600  -17.16500 -21.29100 1.000 48.74602 ? 245 ASP A C   1 
ATOM   1927 O O   . ASP A 1 245 ? 6.75300  -17.89400 -20.42800 1.000 44.43828 ? 245 ASP A O   1 
ATOM   1928 C CB  . ASP A 1 245 ? 8.05800  -18.07200 -23.48200 1.000 47.22333 ? 245 ASP A CB  1 
ATOM   1929 C CG  . ASP A 1 245 ? 7.67600  -18.52800 -24.87200 1.000 59.26226 ? 245 ASP A CG  1 
ATOM   1930 O OD1 . ASP A 1 245 ? 6.49600  -18.37000 -25.25200 1.000 66.68519 ? 245 ASP A OD1 1 
ATOM   1931 O OD2 . ASP A 1 245 ? 8.55700  -19.04700 -25.58700 1.000 60.67941 ? 245 ASP A OD2 1 
ATOM   1932 N N   . HIS A 1 246 ? 8.10700  -16.18100 -20.98800 1.000 45.73213 ? 246 HIS A N   1 
ATOM   1933 C CA  . HIS A 1 246 ? 8.43200  -15.88000 -19.59700 1.000 49.04194 ? 246 HIS A CA  1 
ATOM   1934 C C   . HIS A 1 246 ? 7.18200  -15.51100 -18.80700 1.000 46.12780 ? 246 HIS A C   1 
ATOM   1935 O O   . HIS A 1 246 ? 7.02700  -15.92200 -17.65000 1.000 45.29214 ? 246 HIS A O   1 
ATOM   1936 C CB  . HIS A 1 246 ? 9.46000  -14.75000 -19.52900 1.000 45.28700 ? 246 HIS A CB  1 
ATOM   1937 C CG  . HIS A 1 246 ? 10.81400 -15.12800 -20.04200 1.000 47.02996 ? 246 HIS A CG  1 
ATOM   1938 N ND1 . HIS A 1 246 ? 11.67000 -14.21500 -20.62200 1.000 46.16485 ? 246 HIS A ND1 1 
ATOM   1939 C CD2 . HIS A 1 246 ? 11.46700 -16.31500 -20.05300 1.000 43.27466 ? 246 HIS A CD2 1 
ATOM   1940 C CE1 . HIS A 1 246 ? 12.78900 -14.82400 -20.97100 1.000 40.28179 ? 246 HIS A CE1 1 
ATOM   1941 N NE2 . HIS A 1 246 ? 12.69200 -16.09900 -20.63600 1.000 45.97571 ? 246 HIS A NE2 1 
ATOM   1942 N N   . VAL A 1 247 ? 6.28000  -14.73600 -19.41400 1.000 41.23624 ? 247 VAL A N   1 
ATOM   1943 C CA  . VAL A 1 247 ? 5.03200  -14.39100 -18.74000 1.000 44.38594 ? 247 VAL A CA  1 
ATOM   1944 C C   . VAL A 1 247 ? 4.19200  -15.63900 -18.49400 1.000 44.75773 ? 247 VAL A C   1 
ATOM   1945 O O   . VAL A 1 247 ? 3.58500  -15.79200 -17.42700 1.000 49.25820 ? 247 VAL A O   1 
ATOM   1946 C CB  . VAL A 1 247 ? 4.25700  -13.33600 -19.55000 1.000 45.44336 ? 247 VAL A CB  1 
ATOM   1947 C CG1 . VAL A 1 247 ? 2.91900  -13.03800 -18.88800 1.000 45.00489 ? 247 VAL A CG1 1 
ATOM   1948 C CG2 . VAL A 1 247 ? 5.07900  -12.06700 -19.68900 1.000 41.73829 ? 247 VAL A CG2 1 
ATOM   1949 N N   . ASP A 1 248 ? 4.15000  -16.55500 -19.46500 1.000 42.15364 ? 248 ASP A N   1 
ATOM   1950 C CA  . ASP A 1 248 ? 3.35000  -17.76600 -19.29600 1.000 46.74190 ? 248 ASP A CA  1 
ATOM   1951 C C   . ASP A 1 248 ? 3.92600  -18.66600 -18.21100 1.000 45.58002 ? 248 ASP A C   1 
ATOM   1952 O O   . ASP A 1 248 ? 3.17500  -19.32100 -17.47800 1.000 48.12925 ? 248 ASP A O   1 
ATOM   1953 C CB  . ASP A 1 248 ? 3.24800  -18.52600 -20.62000 1.000 50.11908 ? 248 ASP A CB  1 
ATOM   1954 C CG  . ASP A 1 248 ? 2.37600  -17.81500 -21.63800 1.000 53.18607 ? 248 ASP A CG  1 
ATOM   1955 O OD1 . ASP A 1 248 ? 1.46500  -17.05800 -21.22700 1.000 52.72869 ? 248 ASP A OD1 1 
ATOM   1956 O OD2 . ASP A 1 248 ? 2.60300  -18.01900 -22.85100 1.000 54.73016 ? 248 ASP A OD2 1 
ATOM   1957 N N   . ILE A 1 249 ? 5.25500  -18.71800 -18.09600 1.000 47.53361 ? 249 ILE A N   1 
ATOM   1958 C CA  . ILE A 1 249 ? 5.87900  -19.53000 -17.05500 1.000 45.78910 ? 249 ILE A CA  1 
ATOM   1959 C C   . ILE A 1 249 ? 5.57200  -18.95400 -15.67900 1.000 37.43459 ? 249 ILE A C   1 
ATOM   1960 O O   . ILE A 1 249 ? 5.41800  -19.69300 -14.69900 1.000 40.78902 ? 249 ILE A O   1 
ATOM   1961 C CB  . ILE A 1 249 ? 7.39500  -19.64400 -17.30800 1.000 46.27354 ? 249 ILE A CB  1 
ATOM   1962 C CG1 . ILE A 1 249 ? 7.66400  -20.31100 -18.65900 1.000 37.72752 ? 249 ILE A CG1 1 
ATOM   1963 C CG2 . ILE A 1 249 ? 8.07700  -20.43000 -16.19800 1.000 45.23032 ? 249 ILE A CG2 1 
ATOM   1964 C CD1 . ILE A 1 249 ? 9.11600  -20.29500 -19.07000 1.000 36.75410 ? 249 ILE A CD1 1 
ATOM   1965 N N   . LEU A 1 250 ? 5.46400  -17.63000 -15.58500 1.000 39.48714 ? 250 LEU A N   1 
ATOM   1966 C CA  . LEU A 1 250 ? 5.09000  -16.95400 -14.34900 1.000 41.70895 ? 250 LEU A CA  1 
ATOM   1967 C C   . LEU A 1 250 ? 3.58100  -16.91400 -14.13300 1.000 45.38436 ? 250 LEU A C   1 
ATOM   1968 O O   . LEU A 1 250 ? 3.12600  -16.32000 -13.15000 1.000 48.54582 ? 250 LEU A O   1 
ATOM   1969 C CB  . LEU A 1 250 ? 5.65900  -15.53100 -14.33800 1.000 37.11209 ? 250 LEU A CB  1 
ATOM   1970 C CG  . LEU A 1 250 ? 7.18900  -15.41000 -14.28900 1.000 42.05837 ? 250 LEU A CG  1 
ATOM   1971 C CD1 . LEU A 1 250 ? 7.63500  -13.99300 -14.61900 1.000 36.40083 ? 250 LEU A CD1 1 
ATOM   1972 C CD2 . LEU A 1 250 ? 7.72800  -15.83200 -12.92500 1.000 31.33817 ? 250 LEU A CD2 1 
ATOM   1973 N N   . GLY A 1 251 ? 2.80900  -17.53500 -15.02100 1.000 42.95556 ? 251 GLY A N   1 
ATOM   1974 C CA  . GLY A 1 251 ? 1.36700  -17.53100 -14.94400 1.000 47.94473 ? 251 GLY A CA  1 
ATOM   1975 C C   . GLY A 1 251 ? 0.80500  -18.07800 -13.64500 1.000 45.25347 ? 251 GLY A C   1 
ATOM   1976 O O   . GLY A 1 251 ? 0.11000  -17.37200 -12.90700 1.000 47.14525 ? 251 GLY A O   1 
ATOM   1977 N N   . PRO A 1 252 ? 1.07800  -19.35600 -13.35000 1.000 39.41847 ? 252 PRO A N   1 
ATOM   1978 C CA  . PRO A 1 252 ? 0.53500  -19.95800 -12.11700 1.000 38.12662 ? 252 PRO A CA  1 
ATOM   1979 C C   . PRO A 1 252 ? 0.87100  -19.19300 -10.84700 1.000 42.12989 ? 252 PRO A C   1 
ATOM   1980 O O   . PRO A 1 252 ? 0.03200  -19.11400 -9.94000  1.000 43.52555 ? 252 PRO A O   1 
ATOM   1981 C CB  . PRO A 1 252 ? 1.16700  -21.35600 -12.11900 1.000 48.05636 ? 252 PRO A CB  1 
ATOM   1982 C CG  . PRO A 1 252 ? 1.37800  -21.66000 -13.55900 1.000 42.35954 ? 252 PRO A CG  1 
ATOM   1983 C CD  . PRO A 1 252 ? 1.74800  -20.35600 -14.20200 1.000 42.52587 ? 252 PRO A CD  1 
ATOM   1984 N N   . LEU A 1 253 ? 2.07800  -18.63400 -10.74600 1.000 45.60580 ? 253 LEU A N   1 
ATOM   1985 C CA  . LEU A 1 253 ? 2.40000  -17.80000 -9.59400  1.000 43.81579 ? 253 LEU A CA  1 
ATOM   1986 C C   . LEU A 1 253 ? 1.62300  -16.49200 -9.61600  1.000 45.21303 ? 253 LEU A C   1 
ATOM   1987 O O   . LEU A 1 253 ? 1.26600  -15.96800 -8.55500  1.000 47.28092 ? 253 LEU A O   1 
ATOM   1988 C CB  . LEU A 1 253 ? 3.90000  -17.52000 -9.54700  1.000 43.14914 ? 253 LEU A CB  1 
ATOM   1989 C CG  . LEU A 1 253 ? 4.78800  -18.67700 -9.09300  1.000 41.30647 ? 253 LEU A CG  1 
ATOM   1990 C CD1 . LEU A 1 253 ? 6.25200  -18.29700 -9.23900  1.000 32.98680 ? 253 LEU A CD1 1 
ATOM   1991 C CD2 . LEU A 1 253 ? 4.46700  -19.05300 -7.65600  1.000 37.12028 ? 253 LEU A CD2 1 
ATOM   1992 N N   . SER A 1 254 ? 1.35500  -15.95200 -10.80800 1.000 45.78335 ? 254 SER A N   1 
ATOM   1993 C CA  . SER A 1 254 ? 0.59000  -14.71300 -10.90400 1.000 45.87086 ? 254 SER A CA  1 
ATOM   1994 C C   . SER A 1 254 ? -0.85700 -14.92300 -10.48000 1.000 44.54013 ? 254 SER A C   1 
ATOM   1995 O O   . SER A 1 254 ? -1.43200 -14.08600 -9.77600  1.000 46.92885 ? 254 SER A O   1 
ATOM   1996 C CB  . SER A 1 254 ? 0.65500  -14.16500 -12.32900 1.000 47.81114 ? 254 SER A CB  1 
ATOM   1997 O OG  . SER A 1 254 ? -0.07200 -12.95600 -12.43600 1.000 51.38921 ? 254 SER A OG  1 
ATOM   1998 N N   . ALA A 1 255 ? -1.46200 -16.03600 -10.89900 1.000 44.88353 ? 255 ALA A N   1 
ATOM   1999 C CA  . ALA A 1 255 ? -2.83700 -16.31600 -10.50700 1.000 47.29666 ? 255 ALA A CA  1 
ATOM   2000 C C   . ALA A 1 255 ? -2.93700 -16.67500 -9.03200  1.000 47.94507 ? 255 ALA A C   1 
ATOM   2001 O O   . ALA A 1 255 ? -3.91800 -16.31100 -8.37400  1.000 50.68109 ? 255 ALA A O   1 
ATOM   2002 C CB  . ALA A 1 255 ? -3.41200 -17.43900 -11.37100 1.000 48.39715 ? 255 ALA A CB  1 
ATOM   2003 N N   . GLN A 1 256 ? -1.93900 -17.38200 -8.49700  1.000 47.51658 ? 256 GLN A N   1 
ATOM   2004 C CA  . GLN A 1 256 ? -1.96000 -17.74000 -7.08200  1.000 43.85928 ? 256 GLN A CA  1 
ATOM   2005 C C   . GLN A 1 256 ? -1.96400 -16.49600 -6.20200  1.000 46.72799 ? 256 GLN A C   1 
ATOM   2006 O O   . GLN A 1 256 ? -2.81100 -16.35300 -5.31400  1.000 44.62958 ? 256 GLN A O   1 
ATOM   2007 C CB  . GLN A 1 256 ? -0.76500 -18.63300 -6.75100  1.000 47.29133 ? 256 GLN A CB  1 
ATOM   2008 C CG  . GLN A 1 256 ? -0.71000 -19.09600 -5.30800  1.000 42.48226 ? 256 GLN A CG  1 
ATOM   2009 C CD  . GLN A 1 256 ? 0.51800  -19.94100 -5.01700  1.000 55.82247 ? 256 GLN A CD  1 
ATOM   2010 O OE1 . GLN A 1 256 ? 1.14000  -20.48900 -5.92900  1.000 56.96537 ? 256 GLN A OE1 1 
ATOM   2011 N NE2 . GLN A 1 256 ? 0.87800  -20.04400 -3.74000  1.000 48.91083 ? 256 GLN A NE2 1 
ATOM   2012 N N   . THR A 1 257 ? -1.03300 -15.57300 -6.44500  1.000 41.11330 ? 257 THR A N   1 
ATOM   2013 C CA  . THR A 1 257 ? -0.92100 -14.38700 -5.60800  1.000 46.06274 ? 257 THR A CA  1 
ATOM   2014 C C   . THR A 1 257 ? -1.85600 -13.25900 -6.02800  1.000 41.62872 ? 257 THR A C   1 
ATOM   2015 O O   . THR A 1 257 ? -1.91900 -12.24000 -5.33100  1.000 41.36008 ? 257 THR A O   1 
ATOM   2016 C CB  . THR A 1 257 ? 0.52500  -13.87300 -5.60000  1.000 40.42806 ? 257 THR A CB  1 
ATOM   2017 O OG1 . THR A 1 257 ? 0.88200  -13.41400 -6.90800  1.000 42.00016 ? 257 THR A OG1 1 
ATOM   2018 C CG2 . THR A 1 257 ? 1.47500  -14.97800 -5.18200  1.000 41.06236 ? 257 THR A CG2 1 
ATOM   2019 N N   . GLY A 1 258 ? -2.57900 -13.40900 -7.13400  1.000 40.90178 ? 258 GLY A N   1 
ATOM   2020 C CA  . GLY A 1 258 ? -3.45900 -12.34900 -7.58100  1.000 40.15016 ? 258 GLY A CA  1 
ATOM   2021 C C   . GLY A 1 258 ? -2.75800 -11.10100 -8.06400  1.000 45.04150 ? 258 GLY A C   1 
ATOM   2022 O O   . GLY A 1 258 ? -3.39000 -10.04800 -8.16400  1.000 54.11153 ? 258 GLY A O   1 
ATOM   2023 N N   . ILE A 1 259 ? -1.46700 -11.18600 -8.37100  1.000 42.16967 ? 259 ILE A N   1 
ATOM   2024 C CA  . ILE A 1 259 ? -0.68500 -10.05200 -8.84900  1.000 43.21045 ? 259 ILE A CA  1 
ATOM   2025 C C   . ILE A 1 259 ? -0.34100 -10.30300 -10.30900 1.000 47.72741 ? 259 ILE A C   1 
ATOM   2026 O O   . ILE A 1 259 ? 0.31400  -11.30200 -10.63600 1.000 43.81660 ? 259 ILE A O   1 
ATOM   2027 C CB  . ILE A 1 259 ? 0.58900  -9.84700  -8.01600  1.000 43.68264 ? 259 ILE A CB  1 
ATOM   2028 C CG1 . ILE A 1 259 ? 0.24200  -9.70400  -6.53400  1.000 40.67948 ? 259 ILE A CG1 1 
ATOM   2029 C CG2 . ILE A 1 259 ? 1.36000  -8.63000  -8.51100  1.000 44.84348 ? 259 ILE A CG2 1 
ATOM   2030 C CD1 . ILE A 1 259 ? 1.43700  -9.80100  -5.61800  1.000 42.95423 ? 259 ILE A CD1 1 
ATOM   2031 N N   . ALA A 1 260 ? -0.78100 -9.40100  -11.18400 1.000 45.84871 ? 260 ALA A N   1 
ATOM   2032 C CA  . ALA A 1 260 ? -0.47400 -9.52800  -12.60100 1.000 46.84974 ? 260 ALA A CA  1 
ATOM   2033 C C   . ALA A 1 260 ? 1.03200  -9.47100  -12.83000 1.000 46.16770 ? 260 ALA A C   1 
ATOM   2034 O O   . ALA A 1 260 ? 1.77400  -8.82200  -12.08600 1.000 49.10987 ? 260 ALA A O   1 
ATOM   2035 C CB  . ALA A 1 260 ? -1.17100 -8.42600  -13.39900 1.000 44.75074 ? 260 ALA A CB  1 
ATOM   2036 N N   . VAL A 1 261 ? 1.48100  -10.17200 -13.87400 1.000 42.05215 ? 261 VAL A N   1 
ATOM   2037 C CA  . VAL A 1 261 ? 2.90500  -10.21400 -14.19600 1.000 40.13296 ? 261 VAL A CA  1 
ATOM   2038 C C   . VAL A 1 261 ? 3.42800  -8.81500  -14.49600 1.000 45.85406 ? 261 VAL A C   1 
ATOM   2039 O O   . VAL A 1 261 ? 4.50100  -8.42000  -14.01900 1.000 40.01146 ? 261 VAL A O   1 
ATOM   2040 C CB  . VAL A 1 261 ? 3.15200  -11.17900 -15.37100 1.000 45.09894 ? 261 VAL A CB  1 
ATOM   2041 C CG1 . VAL A 1 261 ? 4.55800  -11.00500 -15.92800 1.000 41.02365 ? 261 VAL A CG1 1 
ATOM   2042 C CG2 . VAL A 1 261 ? 2.92200  -12.61500 -14.93100 1.000 42.98805 ? 261 VAL A CG2 1 
ATOM   2043 N N   . LEU A 1 262 ? 2.67700  -8.03900  -15.28300 1.000 47.71991 ? 262 LEU A N   1 
ATOM   2044 C CA  . LEU A 1 262 ? 3.11900  -6.69200  -15.62600 1.000 42.41692 ? 262 LEU A CA  1 
ATOM   2045 C C   . LEU A 1 262 ? 3.16600  -5.79000  -14.40000 1.000 44.23840 ? 262 LEU A C   1 
ATOM   2046 O O   . LEU A 1 262 ? 4.03000  -4.90900  -14.30700 1.000 39.58697 ? 262 LEU A O   1 
ATOM   2047 C CB  . LEU A 1 262 ? 2.20400  -6.09100  -16.69400 1.000 47.81086 ? 262 LEU A CB  1 
ATOM   2048 C CG  . LEU A 1 262 ? 2.17300  -6.75100  -18.07600 1.000 41.63029 ? 262 LEU A CG  1 
ATOM   2049 C CD1 . LEU A 1 262 ? 3.58300  -7.10500  -18.53300 1.000 41.06085 ? 262 LEU A CD1 1 
ATOM   2050 C CD2 . LEU A 1 262 ? 1.25900  -7.97300  -18.10400 1.000 47.26553 ? 262 LEU A CD2 1 
ATOM   2051 N N   . ASP A 1 263 ? 2.24700  -5.98700  -13.45200 1.000 39.35719 ? 263 ASP A N   1 
ATOM   2052 C CA  . ASP A 1 263 ? 2.31800  -5.24000  -12.20200 1.000 40.19297 ? 263 ASP A CA  1 
ATOM   2053 C C   . ASP A 1 263 ? 3.56800  -5.61400  -11.41400 1.000 47.94164 ? 263 ASP A C   1 
ATOM   2054 O O   . ASP A 1 263 ? 4.23200  -4.74200  -10.84100 1.000 41.50038 ? 263 ASP A O   1 
ATOM   2055 C CB  . ASP A 1 263 ? 1.05700  -5.47800  -11.36900 1.000 42.91489 ? 263 ASP A CB  1 
ATOM   2056 C CG  . ASP A 1 263 ? -0.19400 -4.89700  -12.01600 1.000 42.88326 ? 263 ASP A CG  1 
ATOM   2057 O OD1 . ASP A 1 263 ? -0.10500 -4.38700  -13.15300 1.000 43.63654 ? 263 ASP A OD1 1 
ATOM   2058 O OD2 . ASP A 1 263 ? -1.27000 -4.94900  -11.38300 1.000 43.88545 ? 263 ASP A OD2 1 
ATOM   2059 N N   . MET A 1 264 ? 3.91500  -6.90400  -11.38500 1.000 47.32222 ? 264 MET A N   1 
ATOM   2060 C CA  . MET A 1 264 ? 5.16200  -7.29800  -10.74000 1.000 44.18921 ? 264 MET A CA  1 
ATOM   2061 C C   . MET A 1 264 ? 6.37000  -6.74300  -11.48200 1.000 39.43908 ? 264 MET A C   1 
ATOM   2062 O O   . MET A 1 264 ? 7.37400  -6.39600  -10.85000 1.000 43.69720 ? 264 MET A O   1 
ATOM   2063 C CB  . MET A 1 264 ? 5.25600  -8.82100  -10.63200 1.000 40.64568 ? 264 MET A CB  1 
ATOM   2064 C CG  . MET A 1 264 ? 6.35000  -9.29200  -9.68800  1.000 38.81878 ? 264 MET A CG  1 
ATOM   2065 S SD  . MET A 1 264 ? 6.07200  -8.77300  -7.97800  1.000 41.57976 ? 264 MET A SD  1 
ATOM   2066 C CE  . MET A 1 264 ? 5.55300  -10.32000 -7.23700  1.000 37.80628 ? 264 MET A CE  1 
ATOM   2067 N N   . CYS A 1 265 ? 6.29200  -6.64000  -12.81200 1.000 40.22229 ? 265 CYS A N   1 
ATOM   2068 C CA  . CYS A 1 265 ? 7.37300  -6.01500  -13.56900 1.000 38.00459 ? 265 CYS A CA  1 
ATOM   2069 C C   . CYS A 1 265 ? 7.54700  -4.55500  -13.17700 1.000 40.87819 ? 265 CYS A C   1 
ATOM   2070 O O   . CYS A 1 265 ? 8.67300  -4.04700  -13.13300 1.000 44.59404 ? 265 CYS A O   1 
ATOM   2071 C CB  . CYS A 1 265 ? 7.10700  -6.13000  -15.07000 1.000 39.72326 ? 265 CYS A CB  1 
ATOM   2072 S SG  . CYS A 1 265 ? 7.17600  -7.81100  -15.72100 1.000 45.50623 ? 265 CYS A SG  1 
ATOM   2073 N N   . ALA A 1 266 ? 6.44000  -3.86200  -12.89300 1.000 47.80464 ? 266 ALA A N   1 
ATOM   2074 C CA  . ALA A 1 266 ? 6.52800  -2.46200  -12.49000 1.000 43.19979 ? 266 ALA A CA  1 
ATOM   2075 C C   . ALA A 1 266 ? 7.16400  -2.32100  -11.11400 1.000 44.05983 ? 266 ALA A C   1 
ATOM   2076 O O   . ALA A 1 266 ? 7.90400  -1.36500  -10.86200 1.000 44.36454 ? 266 ALA A O   1 
ATOM   2077 C CB  . ALA A 1 266 ? 5.14300  -1.82200  -12.50700 1.000 45.93348 ? 266 ALA A CB  1 
ATOM   2078 N N   . SER A 1 267 ? 6.87900  -3.25800  -10.20700 1.000 46.52451 ? 267 SER A N   1 
ATOM   2079 C CA  . SER A 1 267 ? 7.55600  -3.25600  -8.91500  1.000 48.91682 ? 267 SER A CA  1 
ATOM   2080 C C   . SER A 1 267 ? 9.04900  -3.51000  -9.07700  1.000 42.34863 ? 267 SER A C   1 
ATOM   2081 O O   . SER A 1 267 ? 9.86900  -2.88200  -8.39700  1.000 39.24322 ? 267 SER A O   1 
ATOM   2082 C CB  . SER A 1 267 ? 6.92600  -4.29700  -7.99100  1.000 41.02525 ? 267 SER A CB  1 
ATOM   2083 O OG  . SER A 1 267 ? 5.63400  -3.88900  -7.58100  1.000 43.65185 ? 267 SER A OG  1 
ATOM   2084 N N   . LEU A 1 268 ? 9.42200  -4.42300  -9.97700  1.000 40.64326 ? 268 LEU A N   1 
ATOM   2085 C CA  . LEU A 1 268 ? 10.83600 -4.66400  -10.24300 1.000 41.74043 ? 268 LEU A CA  1 
ATOM   2086 C C   . LEU A 1 268 ? 11.48100 -3.46800  -10.92800 1.000 44.13289 ? 268 LEU A C   1 
ATOM   2087 O O   . LEU A 1 268 ? 12.66500 -3.18900  -10.70500 1.000 44.52177 ? 268 LEU A O   1 
ATOM   2088 C CB  . LEU A 1 268 ? 11.00300 -5.92500  -11.09400 1.000 36.15168 ? 268 LEU A CB  1 
ATOM   2089 C CG  . LEU A 1 268 ? 12.42000 -6.27600  -11.54700 1.000 29.17951 ? 268 LEU A CG  1 
ATOM   2090 C CD1 . LEU A 1 268 ? 13.34100 -6.38700  -10.34700 1.000 41.67749 ? 268 LEU A CD1 1 
ATOM   2091 C CD2 . LEU A 1 268 ? 12.43000 -7.56600  -12.34800 1.000 31.08195 ? 268 LEU A CD2 1 
ATOM   2092 N N   . LYS A 1 269 ? 10.74300 -2.75400  -11.76500 1.000 41.47375 ? 269 LYS A N   1 
ATOM   2093 C CA  . LYS A 1 269 ? 11.30500 -1.54200  -12.41500 1.000 46.36046 ? 269 LYS A CA  1 
ATOM   2094 C C   . LYS A 1 269 ? 11.73400 -0.52100  -11.35300 1.000 43.56485 ? 269 LYS A C   1 
ATOM   2095 O O   . LYS A 1 269 ? 12.87900 -0.05200  -11.41100 1.000 41.75064 ? 269 LYS A O   1 
ATOM   2096 C CB  . LYS A 1 269 ? 10.30800 -0.93700  -13.40800 1.000 47.17368 ? 269 LYS A CB  1 
ATOM   2097 C CG  . LYS A 1 269 ? 10.82000 0.27000   -14.17900 1.000 49.25369 ? 269 LYS A CG  1 
ATOM   2098 C CD  . LYS A 1 269 ? 9.82800  0.80600   -15.17900 1.000 62.29000 ? 269 LYS A CD  1 
ATOM   2099 C CE  . LYS A 1 269 ? 10.33200 2.02200   -15.92800 1.000 64.37819 ? 269 LYS A CE  1 
ATOM   2100 N NZ  . LYS A 1 269 ? 9.33500  2.52500   -16.90200 1.000 65.47720 ? 269 LYS A NZ  1 
ATOM   2101 N N   . GLU A 1 270 ? 10.83700 -0.18300  -10.43500 1.000 40.27590 ? 270 GLU A N   1 
ATOM   2102 C CA  . GLU A 1 270 ? 11.14500 0.81100   -9.38000  1.000 44.98376 ? 270 GLU A CA  1 
ATOM   2103 C C   . GLU A 1 270 ? 12.35100 0.34500   -8.56300  1.000 46.24066 ? 270 GLU A C   1 
ATOM   2104 O O   . GLU A 1 270 ? 13.13800 1.19500   -8.14500  1.000 45.96110 ? 270 GLU A O   1 
ATOM   2105 C CB  . GLU A 1 270 ? 9.92200  1.02000   -8.49000  1.000 40.79499 ? 270 GLU A CB  1 
ATOM   2106 C CG  . GLU A 1 270 ? 8.64600  1.24700   -9.26700  1.000 52.14987 ? 270 GLU A CG  1 
ATOM   2107 C CD  . GLU A 1 270 ? 8.54300  2.60400   -9.93400  1.000 53.05486 ? 270 GLU A CD  1 
ATOM   2108 O OE1 . GLU A 1 270 ? 8.62900  3.61100   -9.21600  1.000 59.84449 ? 270 GLU A OE1 1 
ATOM   2109 O OE2 . GLU A 1 270 ? 8.37000  2.64800   -11.16400 1.000 52.80232 ? 270 GLU A OE2 1 
ATOM   2110 N N   . LEU A 1 271 ? 12.48200 -0.96100  -8.35700  1.000 41.60406 ? 271 LEU A N   1 
ATOM   2111 C CA  . LEU A 1 271 ? 13.60400 -1.50200  -7.55700  1.000 42.33940 ? 271 LEU A CA  1 
ATOM   2112 C C   . LEU A 1 271 ? 14.92300 -1.30600  -8.31000  1.000 42.16011 ? 271 LEU A C   1 
ATOM   2113 O O   . LEU A 1 271 ? 15.92700 -1.05600  -7.65500  1.000 43.64119 ? 271 LEU A O   1 
ATOM   2114 C CB  . LEU A 1 271 ? 13.34000 -2.98200  -7.27400  1.000 45.28127 ? 271 LEU A CB  1 
ATOM   2115 C CG  . LEU A 1 271 ? 12.35400 -3.28900  -6.15100  1.000 43.46892 ? 271 LEU A CG  1 
ATOM   2116 C CD1 . LEU A 1 271 ? 12.14800 -4.78700  -6.01500  1.000 36.89116 ? 271 LEU A CD1 1 
ATOM   2117 C CD2 . LEU A 1 271 ? 12.82700 -2.69600  -4.83600  1.000 40.32232 ? 271 LEU A CD2 1 
ATOM   2118 N N   . LEU A 1 272 ? 14.90400 -1.43000  -9.63300  1.000 38.48621 ? 272 LEU A N   1 
ATOM   2119 C CA  . LEU A 1 272 ? 16.13000 -1.21200  -10.39200 1.000 44.87540 ? 272 LEU A CA  1 
ATOM   2120 C C   . LEU A 1 272 ? 16.51400 0.26000   -10.42800 1.000 44.26090 ? 272 LEU A C   1 
ATOM   2121 O O   . LEU A 1 272 ? 17.70500 0.59000   -10.40800 1.000 44.18342 ? 272 LEU A O   1 
ATOM   2122 C CB  . LEU A 1 272 ? 15.97400 -1.74800  -11.81500 1.000 42.70523 ? 272 LEU A CB  1 
ATOM   2123 C CG  . LEU A 1 272 ? 15.82100 -3.26000  -11.95600 1.000 42.96627 ? 272 LEU A CG  1 
ATOM   2124 C CD1 . LEU A 1 272 ? 15.56700 -3.63500  -13.40600 1.000 41.32929 ? 272 LEU A CD1 1 
ATOM   2125 C CD2 . LEU A 1 272 ? 17.05900 -3.96000  -11.42700 1.000 45.34790 ? 272 LEU A CD2 1 
ATOM   2126 N N   . GLN A 1 273 ? 15.52800 1.15400   -10.47500 1.000 46.93720 ? 273 GLN A N   1 
ATOM   2127 C CA  . GLN A 1 273 ? 15.79600 2.58100   -10.59700 1.000 43.46310 ? 273 GLN A CA  1 
ATOM   2128 C C   . GLN A 1 273 ? 16.04900 3.25700   -9.25900  1.000 46.00610 ? 273 GLN A C   1 
ATOM   2129 O O   . GLN A 1 273 ? 16.85600 4.19100   -9.19000  1.000 57.00571 ? 273 GLN A O   1 
ATOM   2130 C CB  . GLN A 1 273 ? 14.63100 3.26700   -11.30900 1.000 43.80512 ? 273 GLN A CB  1 
ATOM   2131 C CG  . GLN A 1 273 ? 14.36900 2.71800   -12.69700 1.000 44.84554 ? 273 GLN A CG  1 
ATOM   2132 C CD  . GLN A 1 273 ? 13.21800 3.41200   -13.39500 1.000 47.49283 ? 273 GLN A CD  1 
ATOM   2133 O OE1 . GLN A 1 273 ? 12.27200 3.87100   -12.75600 1.000 46.20806 ? 273 GLN A OE1 1 
ATOM   2134 N NE2 . GLN A 1 273 ? 13.29600 3.49500   -14.71700 1.000 55.76935 ? 273 GLN A NE2 1 
ATOM   2135 N N   . ASN A 1 274 ? 15.38800 2.80800   -8.19400  1.000 49.81707 ? 274 ASN A N   1 
ATOM   2136 C CA  . ASN A 1 274 ? 15.51300 3.42400   -6.88200  1.000 46.25685 ? 274 ASN A CA  1 
ATOM   2137 C C   . ASN A 1 274 ? 16.34200 2.60400   -5.90600  1.000 52.06978 ? 274 ASN A C   1 
ATOM   2138 O O   . ASN A 1 274 ? 16.56000 3.04800   -4.77500  1.000 52.90075 ? 274 ASN A O   1 
ATOM   2139 C CB  . ASN A 1 274 ? 14.12500 3.67400   -6.28500  1.000 48.08291 ? 274 ASN A CB  1 
ATOM   2140 C CG  . ASN A 1 274 ? 13.32700 4.68300   -7.07800  1.000 54.43846 ? 274 ASN A CG  1 
ATOM   2141 O OD1 . ASN A 1 274 ? 12.72900 4.35400   -8.10400  1.000 55.88640 ? 274 ASN A OD1 1 
ATOM   2142 N ND2 . ASN A 1 274 ? 13.30700 5.92400   -6.60300  1.000 59.96870 ? 274 ASN A ND2 1 
ATOM   2143 N N   . GLY A 1 275 ? 16.81200 1.42900   -6.30400  1.000 51.80679 ? 275 GLY A N   1 
ATOM   2144 C CA  . GLY A 1 275 ? 17.52300 0.57900   -5.37200  1.000 49.41447 ? 275 GLY A CA  1 
ATOM   2145 C C   . GLY A 1 275 ? 16.57300 -0.06400  -4.37400  1.000 50.69540 ? 275 GLY A C   1 
ATOM   2146 O O   . GLY A 1 275 ? 15.41700 -0.36100  -4.67700  1.000 48.09685 ? 275 GLY A O   1 
ATOM   2147 N N   . MET A 1 276 ? 17.07900 -0.27300  -3.16100  1.000 51.17228 ? 276 MET A N   1 
ATOM   2148 C CA  . MET A 1 276 ? 16.32000 -0.94600  -2.12000  1.000 49.62891 ? 276 MET A CA  1 
ATOM   2149 C C   . MET A 1 276 ? 16.22100 -0.14100  -0.83200  1.000 50.35622 ? 276 MET A C   1 
ATOM   2150 O O   . MET A 1 276 ? 15.52900 -0.57700  0.09400   1.000 46.20891 ? 276 MET A O   1 
ATOM   2151 C CB  . MET A 1 276 ? 16.93600 -2.32400  -1.82100  1.000 51.91590 ? 276 MET A CB  1 
ATOM   2152 C CG  . MET A 1 276 ? 15.91300 -3.43100  -1.62300  1.000 49.62383 ? 276 MET A CG  1 
ATOM   2153 S SD  . MET A 1 276 ? 16.62500 -5.08200  -1.76500  1.000 53.51660 ? 276 MET A SD  1 
ATOM   2154 C CE  . MET A 1 276 ? 17.13800 -5.08500  -3.47800  1.000 40.46125 ? 276 MET A CE  1 
ATOM   2155 N N   . ASN A 1 277 ? 16.88700 1.01500   -0.74900  1.000 54.95356 ? 277 ASN A N   1 
ATOM   2156 C CA  . ASN A 1 277 ? 16.79200 1.91400   0.40400   1.000 50.35043 ? 277 ASN A CA  1 
ATOM   2157 C C   . ASN A 1 277 ? 17.21900 1.22300   1.69700   1.000 49.87992 ? 277 ASN A C   1 
ATOM   2158 O O   . ASN A 1 277 ? 16.65400 1.46500   2.76500   1.000 51.09658 ? 277 ASN A O   1 
ATOM   2159 C CB  . ASN A 1 277 ? 15.38200 2.49400   0.54000   1.000 47.10463 ? 277 ASN A CB  1 
ATOM   2160 C CG  . ASN A 1 277 ? 15.31300 3.95000   0.13800   1.000 51.50837 ? 277 ASN A CG  1 
ATOM   2161 O OD1 . ASN A 1 277 ? 16.16800 4.44400   -0.59700  1.000 61.18533 ? 277 ASN A OD1 1 
ATOM   2162 N ND2 . ASN A 1 277 ? 14.29600 4.65000   0.62500   1.000 55.52006 ? 277 ASN A ND2 1 
ATOM   2163 N N   . GLY A 1 278 ? 18.22800 0.35900   1.60100   1.000 52.78931 ? 278 GLY A N   1 
ATOM   2164 C CA  . GLY A 1 278 ? 18.71400 -0.35000  2.76800   1.000 48.86006 ? 278 GLY A CA  1 
ATOM   2165 C C   . GLY A 1 278 ? 17.77800 -1.39900  3.32000   1.000 49.61991 ? 278 GLY A C   1 
ATOM   2166 O O   . GLY A 1 278 ? 17.99100 -1.87000  4.44200   1.000 52.44497 ? 278 GLY A O   1 
ATOM   2167 N N   . ARG A 1 279 ? 16.74900 -1.77900  2.57500   1.000 44.98020 ? 279 ARG A N   1 
ATOM   2168 C CA  . ARG A 1 279 ? 15.80500 -2.79700  3.00500   1.000 46.48005 ? 279 ARG A CA  1 
ATOM   2169 C C   . ARG A 1 279 ? 16.19700 -4.14900  2.42400   1.000 45.90960 ? 279 ARG A C   1 
ATOM   2170 O O   . ARG A 1 279 ? 17.12100 -4.26400  1.61500   1.000 48.75050 ? 279 ARG A O   1 
ATOM   2171 C CB  . ARG A 1 279 ? 14.38300 -2.41700  2.58500   1.000 47.11051 ? 279 ARG A CB  1 
ATOM   2172 C CG  . ARG A 1 279 ? 14.00500 -0.99900  2.97100   1.000 48.19605 ? 279 ARG A CG  1 
ATOM   2173 C CD  . ARG A 1 279 ? 12.59600 -0.66400  2.53000   1.000 51.89349 ? 279 ARG A CD  1 
ATOM   2174 N NE  . ARG A 1 279 ? 11.63300 -1.65300  3.00000   1.000 61.74761 ? 279 ARG A NE  1 
ATOM   2175 C CZ  . ARG A 1 279 ? 11.18400 -1.73100  4.24600   1.000 62.77919 ? 279 ARG A CZ  1 
ATOM   2176 N NH1 . ARG A 1 279 ? 11.61500 -0.91000  5.19100   1.000 64.84372 ? 279 ARG A NH1 1 
ATOM   2177 N NH2 . ARG A 1 279 ? 10.27800 -2.65600  4.55200   1.000 59.05560 ? 279 ARG A NH2 1 
ATOM   2178 N N   . THR A 1 280 ? 15.48700 -5.18600  2.85400   1.000 38.48228 ? 280 THR A N   1 
ATOM   2179 C CA  . THR A 1 280 ? 15.78100 -6.53800  2.41100   1.000 39.07316 ? 280 THR A CA  1 
ATOM   2180 C C   . THR A 1 280 ? 14.50800 -7.23000  1.95500   1.000 43.39901 ? 280 THR A C   1 
ATOM   2181 O O   . THR A 1 280 ? 13.41400 -6.96100  2.46000   1.000 45.13828 ? 280 THR A O   1 
ATOM   2182 C CB  . THR A 1 280 ? 16.45000 -7.37500  3.51300   1.000 43.74867 ? 280 THR A CB  1 
ATOM   2183 O OG1 . THR A 1 280 ? 15.57400 -7.47700  4.64300   1.000 42.77169 ? 280 THR A OG1 1 
ATOM   2184 C CG2 . THR A 1 280 ? 17.77000 -6.74200  3.93900   1.000 37.73305 ? 280 THR A CG2 1 
ATOM   2185 N N   . ILE A 1 281 ? 14.67000 -8.12400  0.98700   1.000 38.42581 ? 281 ILE A N   1 
ATOM   2186 C CA  . ILE A 1 281 ? 13.59800 -8.97800  0.49900   1.000 39.31223 ? 281 ILE A CA  1 
ATOM   2187 C C   . ILE A 1 281 ? 14.02800 -10.41500 0.73800   1.000 42.13205 ? 281 ILE A C   1 
ATOM   2188 O O   . ILE A 1 281 ? 15.09200 -10.83300 0.26400   1.000 39.61789 ? 281 ILE A O   1 
ATOM   2189 C CB  . ILE A 1 281 ? 13.30000 -8.72900  -0.98500  1.000 37.70762 ? 281 ILE A CB  1 
ATOM   2190 C CG1 . ILE A 1 281 ? 12.94600 -7.26000  -1.21000  1.000 37.68378 ? 281 ILE A CG1 1 
ATOM   2191 C CG2 . ILE A 1 281 ? 12.17900 -9.63500  -1.45600  1.000 33.30127 ? 281 ILE A CG2 1 
ATOM   2192 C CD1 . ILE A 1 281 ? 12.64400 -6.91400  -2.64900  1.000 40.06900 ? 281 ILE A CD1 1 
ATOM   2193 N N   . LEU A 1 282 ? 13.21900 -11.15900 1.49100   1.000 37.25511 ? 282 LEU A N   1 
ATOM   2194 C CA  . LEU A 1 282 ? 13.53300 -12.54300 1.84400   1.000 37.00732 ? 282 LEU A CA  1 
ATOM   2195 C C   . LEU A 1 282 ? 14.93000 -12.66000 2.44600   1.000 38.35704 ? 282 LEU A C   1 
ATOM   2196 O O   . LEU A 1 282 ? 15.65600 -13.62800 2.20600   1.000 38.62742 ? 282 LEU A O   1 
ATOM   2197 C CB  . LEU A 1 282 ? 13.38300 -13.46300 0.63100   1.000 42.54716 ? 282 LEU A CB  1 
ATOM   2198 C CG  . LEU A 1 282 ? 11.95400 -13.70000 0.14500   1.000 42.08256 ? 282 LEU A CG  1 
ATOM   2199 C CD1 . LEU A 1 282 ? 11.96100 -14.51600 -1.13600  1.000 37.07923 ? 282 LEU A CD1 1 
ATOM   2200 C CD2 . LEU A 1 282 ? 11.13300 -14.39300 1.22200   1.000 39.68137 ? 282 LEU A CD2 1 
ATOM   2201 N N   . GLY A 1 283 ? 15.31600 -11.65500 3.23000   1.000 40.68957 ? 283 GLY A N   1 
ATOM   2202 C CA  . GLY A 1 283 ? 16.60700 -11.64100 3.87900   1.000 38.88121 ? 283 GLY A CA  1 
ATOM   2203 C C   . GLY A 1 283 ? 17.77700 -11.26400 2.99800   1.000 41.07131 ? 283 GLY A C   1 
ATOM   2204 O O   . GLY A 1 283 ? 18.92400 -11.33300 3.46000   1.000 49.30729 ? 283 GLY A O   1 
ATOM   2205 N N   . SER A 1 284 ? 17.53800 -10.87200 1.75100   1.000 41.82792 ? 284 SER A N   1 
ATOM   2206 C CA  . SER A 1 284 ? 18.59800 -10.48800 0.83200   1.000 38.27159 ? 284 SER A CA  1 
ATOM   2207 C C   . SER A 1 284 ? 18.52400 -8.99700  0.53600   1.000 37.93373 ? 284 SER A C   1 
ATOM   2208 O O   . SER A 1 284 ? 17.43300 -8.42900  0.42200   1.000 35.14025 ? 284 SER A O   1 
ATOM   2209 C CB  . SER A 1 284 ? 18.50600 -11.27400 -0.47700  1.000 35.42959 ? 284 SER A CB  1 
ATOM   2210 O OG  . SER A 1 284 ? 19.36400 -10.71500 -1.45800  1.000 37.97331 ? 284 SER A OG  1 
ATOM   2211 N N   . ALA A 1 285 ? 19.69000 -8.36900  0.41200   1.000 39.53021 ? 285 ALA A N   1 
ATOM   2212 C CA  . ALA A 1 285 ? 19.78400 -6.97700  -0.00000  1.000 32.79635 ? 285 ALA A CA  1 
ATOM   2213 C C   . ALA A 1 285 ? 19.97900 -6.81900  -1.50200  1.000 36.60313 ? 285 ALA A C   1 
ATOM   2214 O O   . ALA A 1 285 ? 20.08600 -5.68700  -1.98200  1.000 41.63528 ? 285 ALA A O   1 
ATOM   2215 C CB  . ALA A 1 285 ? 20.92400 -6.28300  0.74600   1.000 30.35978 ? 285 ALA A CB  1 
ATOM   2216 N N   . LEU A 1 286 ? 20.03100 -7.91600  -2.25100  1.000 34.13280 ? 286 LEU A N   1 
ATOM   2217 C CA  . LEU A 1 286 ? 20.12500 -7.88800  -3.70200  1.000 37.62913 ? 286 LEU A CA  1 
ATOM   2218 C C   . LEU A 1 286 ? 18.96000 -8.66100  -4.30500  1.000 41.80998 ? 286 LEU A C   1 
ATOM   2219 O O   . LEU A 1 286 ? 18.26500 -9.42300  -3.62600  1.000 37.12878 ? 286 LEU A O   1 
ATOM   2220 C CB  . LEU A 1 286 ? 21.45200 -8.48200  -4.18800  1.000 36.22805 ? 286 LEU A CB  1 
ATOM   2221 C CG  . LEU A 1 286 ? 22.74000 -7.82600  -3.69500  1.000 46.12343 ? 286 LEU A CG  1 
ATOM   2222 C CD1 . LEU A 1 286 ? 23.94300 -8.65900  -4.11000  1.000 44.52767 ? 286 LEU A CD1 1 
ATOM   2223 C CD2 . LEU A 1 286 ? 22.85900 -6.40300  -4.22100  1.000 40.27240 ? 286 LEU A CD2 1 
ATOM   2224 N N   . LEU A 1 287 ? 18.75800 -8.46300  -5.60500  1.000 35.40601 ? 287 LEU A N   1 
ATOM   2225 C CA  . LEU A 1 287 ? 17.71700 -9.17400  -6.33800  1.000 36.53284 ? 287 LEU A CA  1 
ATOM   2226 C C   . LEU A 1 287 ? 18.24100 -10.55100 -6.73500  1.000 36.92620 ? 287 LEU A C   1 
ATOM   2227 O O   . LEU A 1 287 ? 19.16700 -10.66200 -7.54200  1.000 34.99468 ? 287 LEU A O   1 
ATOM   2228 C CB  . LEU A 1 287 ? 17.28700 -8.36100  -7.55300  1.000 34.42564 ? 287 LEU A CB  1 
ATOM   2229 C CG  . LEU A 1 287 ? 16.66000 -7.01200  -7.19000  1.000 37.37000 ? 287 LEU A CG  1 
ATOM   2230 C CD1 . LEU A 1 287 ? 16.53000 -6.12000  -8.40900  1.000 39.96560 ? 287 LEU A CD1 1 
ATOM   2231 C CD2 . LEU A 1 287 ? 15.30700 -7.21700  -6.52800  1.000 34.25778 ? 287 LEU A CD2 1 
ATOM   2232 N N   . GLU A 1 288 ? 17.65100 -11.59800 -6.16600  1.000 35.39214 ? 288 GLU A N   1 
ATOM   2233 C CA  . GLU A 1 288 ? 18.09300 -12.96200 -6.42400  1.000 34.12357 ? 288 GLU A CA  1 
ATOM   2234 C C   . GLU A 1 288 ? 17.55000 -13.46700 -7.75500  1.000 34.29336 ? 288 GLU A C   1 
ATOM   2235 O O   . GLU A 1 288 ? 16.36100 -13.31700 -8.04800  1.000 31.19865 ? 288 GLU A O   1 
ATOM   2236 C CB  . GLU A 1 288 ? 17.64600 -13.88200 -5.29000  1.000 35.85026 ? 288 GLU A CB  1 
ATOM   2237 C CG  . GLU A 1 288 ? 18.67700 -14.03400 -4.19200  1.000 40.91591 ? 288 GLU A CG  1 
ATOM   2238 C CD  . GLU A 1 288 ? 19.90900 -14.77500 -4.67100  1.000 49.35938 ? 288 GLU A CD  1 
ATOM   2239 O OE1 . GLU A 1 288 ? 19.75300 -15.80000 -5.37500  1.000 50.14254 ? 288 GLU A OE1 1 
ATOM   2240 O OE2 . GLU A 1 288 ? 21.03200 -14.32700 -4.35700  1.000 49.67262 ? 288 GLU A OE2 1 
ATOM   2241 N N   . ASP A 1 289 ? 18.42100 -14.08700 -8.55400  1.000 34.20239 ? 289 ASP A N   1 
ATOM   2242 C CA  . ASP A 1 289 ? 18.02300 -14.59900 -9.86000  1.000 34.45434 ? 289 ASP A CA  1 
ATOM   2243 C C   . ASP A 1 289 ? 18.35700 -16.07800 -10.02700 1.000 33.76100 ? 289 ASP A C   1 
ATOM   2244 O O   . ASP A 1 289 ? 18.39700 -16.57300 -11.15800 1.000 34.72232 ? 289 ASP A O   1 
ATOM   2245 C CB  . ASP A 1 289 ? 18.67100 -13.78000 -10.98000 1.000 30.73252 ? 289 ASP A CB  1 
ATOM   2246 C CG  . ASP A 1 289 ? 20.14800 -14.06700 -11.13700 1.000 33.79435 ? 289 ASP A CG  1 
ATOM   2247 O OD1 . ASP A 1 289 ? 20.79400 -14.48300 -10.14800 1.000 34.62912 ? 289 ASP A OD1 1 
ATOM   2248 O OD2 . ASP A 1 289 ? 20.66500 -13.87000 -12.25800 1.000 36.22338 ? 289 ASP A OD2 1 
ATOM   2249 N N   . GLU A 1 290 ? 18.60500 -16.79600 -8.93300  1.000 35.99751 ? 290 GLU A N   1 
ATOM   2250 C CA  . GLU A 1 290 ? 18.92300 -18.21700 -9.00800  1.000 40.62289 ? 290 GLU A CA  1 
ATOM   2251 C C   . GLU A 1 290 ? 17.77600 -19.09400 -8.51800  1.000 37.37538 ? 290 GLU A C   1 
ATOM   2252 O O   . GLU A 1 290 ? 17.98800 -20.26700 -8.19900  1.000 39.58071 ? 290 GLU A O   1 
ATOM   2253 C CB  . GLU A 1 290 ? 20.20700 -18.52100 -8.23500  1.000 36.36859 ? 290 GLU A CB  1 
ATOM   2254 C CG  . GLU A 1 290 ? 21.41700 -17.78000 -8.78000  1.000 36.35787 ? 290 GLU A CG  1 
ATOM   2255 C CD  . GLU A 1 290 ? 22.72400 -18.51000 -8.53200  1.000 47.52920 ? 290 GLU A CD  1 
ATOM   2256 O OE1 . GLU A 1 290 ? 22.83700 -19.21100 -7.49800  1.000 43.03567 ? 290 GLU A OE1 1 
ATOM   2257 O OE2 . GLU A 1 290 ? 23.63500 -18.38600 -9.38200  1.000 36.52386 ? 290 GLU A OE2 1 
ATOM   2258 N N   . PHE A 1 291 ? 16.56300 -18.54600 -8.45400  1.000 36.50550 ? 291 PHE A N   1 
ATOM   2259 C CA  . PHE A 1 291 ? 15.34800 -19.32100 -8.21800  1.000 35.16678 ? 291 PHE A CA  1 
ATOM   2260 C C   . PHE A 1 291 ? 14.48800 -19.22400 -9.47200  1.000 35.70969 ? 291 PHE A C   1 
ATOM   2261 O O   . PHE A 1 291 ? 14.04200 -18.13100 -9.83700  1.000 32.31638 ? 291 PHE A O   1 
ATOM   2262 C CB  . PHE A 1 291 ? 14.58300 -18.81300 -6.99500  1.000 35.05159 ? 291 PHE A CB  1 
ATOM   2263 C CG  . PHE A 1 291 ? 15.33300 -18.95200 -5.69900  1.000 37.91415 ? 291 PHE A CG  1 
ATOM   2264 C CD1 . PHE A 1 291 ? 15.35600 -20.16000 -5.02100  1.000 36.96744 ? 291 PHE A CD1 1 
ATOM   2265 C CD2 . PHE A 1 291 ? 15.99600 -17.86500 -5.14700  1.000 39.30983 ? 291 PHE A CD2 1 
ATOM   2266 C CE1 . PHE A 1 291 ? 16.04000 -20.28800 -3.82300  1.000 37.80918 ? 291 PHE A CE1 1 
ATOM   2267 C CE2 . PHE A 1 291 ? 16.68100 -17.98500 -3.95100  1.000 39.03682 ? 291 PHE A CE2 1 
ATOM   2268 C CZ  . PHE A 1 291 ? 16.70300 -19.19900 -3.28800  1.000 41.91624 ? 291 PHE A CZ  1 
ATOM   2269 N N   . THR A 1 292 ? 14.26700 -20.35900 -10.13600 1.000 33.42815 ? 292 THR A N   1 
ATOM   2270 C CA  . THR A 1 292 ? 13.35700 -20.40000 -11.27000 1.000 36.20616 ? 292 THR A CA  1 
ATOM   2271 C C   . THR A 1 292 ? 11.91000 -20.47200 -10.78600 1.000 37.97596 ? 292 THR A C   1 
ATOM   2272 O O   . THR A 1 292 ? 11.65200 -20.78700 -9.62100  1.000 34.17179 ? 292 THR A O   1 
ATOM   2273 C CB  . THR A 1 292 ? 13.66400 -21.60300 -12.15700 1.000 30.05549 ? 292 THR A CB  1 
ATOM   2274 O OG1 . THR A 1 292 ? 13.39200 -22.80900 -11.43500 1.000 37.46264 ? 292 THR A OG1 1 
ATOM   2275 C CG2 . THR A 1 292 ? 15.11500 -21.59300 -12.59600 1.000 38.82816 ? 292 THR A CG2 1 
ATOM   2276 N N   . PRO A 1 293 ? 10.94400 -20.16200 -11.65800 1.000 28.25456 ? 293 PRO A N   1 
ATOM   2277 C CA  . PRO A 1 293 ? 9.53400  -20.32000 -11.26500 1.000 35.43257 ? 293 PRO A CA  1 
ATOM   2278 C C   . PRO A 1 293 ? 9.19300  -21.71300 -10.77500 1.000 36.55008 ? 293 PRO A C   1 
ATOM   2279 O O   . PRO A 1 293 ? 8.33700  -21.85600 -9.89200  1.000 36.76374 ? 293 PRO A O   1 
ATOM   2280 C CB  . PRO A 1 293 ? 8.78100  -19.96900 -12.55300 1.000 35.07765 ? 293 PRO A CB  1 
ATOM   2281 C CG  . PRO A 1 293 ? 9.66800  -18.99100 -13.22500 1.000 35.31374 ? 293 PRO A CG  1 
ATOM   2282 C CD  . PRO A 1 293 ? 11.07400 -19.45200 -12.94300 1.000 30.61781 ? 293 PRO A CD  1 
ATOM   2283 N N   . PHE A 1 294 ? 9.83200  -22.74900 -11.32000 1.000 39.62200 ? 294 PHE A N   1 
ATOM   2284 C CA  A PHE A 1 294 ? 9.61700  -24.10200 -10.82000 0.539 40.29114 ? 294 PHE A CA  1 
ATOM   2285 C CA  B PHE A 1 294 ? 9.60600  -24.09700 -10.81600 0.461 40.31818 ? 294 PHE A CA  1 
ATOM   2286 C C   . PHE A 1 294 ? 10.26700 -24.30900 -9.45800  1.000 41.27516 ? 294 PHE A C   1 
ATOM   2287 O O   . PHE A 1 294 ? 9.75200  -25.07900 -8.64000  1.000 41.84415 ? 294 PHE A O   1 
ATOM   2288 C CB  A PHE A 1 294 ? 10.14900 -25.12800 -11.82500 0.539 43.85355 ? 294 PHE A CB  1 
ATOM   2289 C CB  B PHE A 1 294 ? 10.09800 -25.12500 -11.83900 0.461 43.84863 ? 294 PHE A CB  1 
ATOM   2290 C CG  A PHE A 1 294 ? 9.89100  -26.55800 -11.43300 0.539 43.83372 ? 294 PHE A CG  1 
ATOM   2291 C CG  B PHE A 1 294 ? 9.32300  -25.10300 -13.13200 0.461 46.80667 ? 294 PHE A CG  1 
ATOM   2292 C CD1 A PHE A 1 294 ? 8.59800  -27.05300 -11.37900 0.539 47.28001 ? 294 PHE A CD1 1 
ATOM   2293 C CD1 B PHE A 1 294 ? 8.08600  -25.72300 -13.22300 0.461 48.45173 ? 294 PHE A CD1 1 
ATOM   2294 C CD2 A PHE A 1 294 ? 10.94000 -27.41100 -11.13000 0.539 45.86422 ? 294 PHE A CD2 1 
ATOM   2295 C CD2 B PHE A 1 294 ? 9.82100  -24.45000 -14.24800 0.461 47.96447 ? 294 PHE A CD2 1 
ATOM   2296 C CE1 A PHE A 1 294 ? 8.35600  -28.36800 -11.02100 0.539 48.00156 ? 294 PHE A CE1 1 
ATOM   2297 C CE1 B PHE A 1 294 ? 7.36400  -25.69800 -14.40500 0.461 47.75236 ? 294 PHE A CE1 1 
ATOM   2298 C CE2 A PHE A 1 294 ? 10.70400 -28.72800 -10.77300 0.539 44.01492 ? 294 PHE A CE2 1 
ATOM   2299 C CE2 B PHE A 1 294 ? 9.10200  -24.42400 -15.43400 0.461 50.15976 ? 294 PHE A CE2 1 
ATOM   2300 C CZ  A PHE A 1 294 ? 9.41000  -29.20500 -10.71800 0.539 46.78073 ? 294 PHE A CZ  1 
ATOM   2301 C CZ  B PHE A 1 294 ? 7.87300  -25.04900 -15.51100 0.461 47.38862 ? 294 PHE A CZ  1 
ATOM   2302 N N   . ASP A 1 295 ? 11.38600 -23.62500 -9.19400  1.000 38.61544 ? 295 ASP A N   1 
ATOM   2303 C CA  . ASP A 1 295 ? 12.01700 -23.72000 -7.88000  1.000 37.85468 ? 295 ASP A CA  1 
ATOM   2304 C C   . ASP A 1 295 ? 11.17300 -23.04400 -6.81100  1.000 44.04075 ? 295 ASP A C   1 
ATOM   2305 O O   . ASP A 1 295 ? 11.24500 -23.40900 -5.63200  1.000 46.28411 ? 295 ASP A O   1 
ATOM   2306 C CB  . ASP A 1 295 ? 13.40400 -23.08900 -7.89400  1.000 34.49696 ? 295 ASP A CB  1 
ATOM   2307 C CG  . ASP A 1 295 ? 14.34900 -23.78400 -8.82900  1.000 39.32860 ? 295 ASP A CG  1 
ATOM   2308 O OD1 . ASP A 1 295 ? 14.21200 -25.01400 -9.02100  1.000 45.70027 ? 295 ASP A OD1 1 
ATOM   2309 O OD2 . ASP A 1 295 ? 15.23300 -23.09200 -9.37600  1.000 38.02421 ? 295 ASP A OD2 1 
ATOM   2310 N N   . VAL A 1 296 ? 10.40500 -22.02200 -7.18900  1.000 40.06610 ? 296 VAL A N   1 
ATOM   2311 C CA  . VAL A 1 296 ? 9.54400  -21.36100 -6.21400  1.000 36.05567 ? 296 VAL A CA  1 
ATOM   2312 C C   . VAL A 1 296 ? 8.35400  -22.24900 -5.87100  1.000 40.56525 ? 296 VAL A C   1 
ATOM   2313 O O   . VAL A 1 296 ? 8.00700  -22.42000 -4.69700  1.000 43.91854 ? 296 VAL A O   1 
ATOM   2314 C CB  . VAL A 1 296 ? 9.09400  -19.98400 -6.73400  1.000 39.14972 ? 296 VAL A CB  1 
ATOM   2315 C CG1 . VAL A 1 296 ? 8.06000  -19.37800 -5.80400  1.000 38.34601 ? 296 VAL A CG1 1 
ATOM   2316 C CG2 . VAL A 1 296 ? 10.28500 -19.04600 -6.86600  1.000 38.75721 ? 296 VAL A CG2 1 
ATOM   2317 N N   . VAL A 1 297 ? 7.72400  -22.84200 -6.88900  1.000 38.50951 ? 297 VAL A N   1 
ATOM   2318 C CA  . VAL A 1 297 ? 6.56000  -23.69700 -6.65800  1.000 39.84099 ? 297 VAL A CA  1 
ATOM   2319 C C   . VAL A 1 297 ? 6.94500  -24.93500 -5.85500  1.000 48.89002 ? 297 VAL A C   1 
ATOM   2320 O O   . VAL A 1 297 ? 6.19200  -25.38800 -4.98300  1.000 51.13392 ? 297 VAL A O   1 
ATOM   2321 C CB  . VAL A 1 297 ? 5.90700  -24.07000 -8.00300  1.000 38.24378 ? 297 VAL A CB  1 
ATOM   2322 C CG1 . VAL A 1 297 ? 4.84800  -25.12500 -7.80400  1.000 33.46983 ? 297 VAL A CG1 1 
ATOM   2323 C CG2 . VAL A 1 297 ? 5.31500  -22.83700 -8.66500  1.000 36.85418 ? 297 VAL A CG2 1 
ATOM   2324 N N   . ARG A 1 298 ? 8.12400  -25.49700 -6.12600  1.000 47.50220 ? 298 ARG A N   1 
ATOM   2325 C CA  A ARG A 1 298 ? 8.57600  -26.70100 -5.43400  0.587 45.96563 ? 298 ARG A CA  1 
ATOM   2326 C CA  B ARG A 1 298 ? 8.51600  -26.71000 -5.42600  0.413 45.65420 ? 298 ARG A CA  1 
ATOM   2327 C C   . ARG A 1 298 ? 8.75500  -26.44300 -3.94300  1.000 47.59066 ? 298 ARG A C   1 
ATOM   2328 O O   . ARG A 1 298 ? 8.36800  -27.25800 -3.10100  1.000 54.24319 ? 298 ARG A O   1 
ATOM   2329 C CB  A ARG A 1 298 ? 9.88800  -27.18200 -6.06000  0.587 46.55797 ? 298 ARG A CB  1 
ATOM   2330 C CB  B ARG A 1 298 ? 9.76600  -27.29600 -6.05700  0.413 46.55619 ? 298 ARG A CB  1 
ATOM   2331 C CG  A ARG A 1 298 ? 10.83000 -27.94600 -5.12400  0.587 48.34831 ? 298 ARG A CG  1 
ATOM   2332 C CG  B ARG A 1 298 ? 10.94700 -26.35600 -5.78000  0.413 47.56536 ? 298 ARG A CG  1 
ATOM   2333 C CD  A ARG A 1 298 ? 12.24000 -27.99900 -5.69800  0.587 49.78305 ? 298 ARG A CD  1 
ATOM   2334 C CD  B ARG A 1 298 ? 12.23200 -26.85000 -6.23100  0.413 49.61148 ? 298 ARG A CD  1 
ATOM   2335 N NE  A ARG A 1 298 ? 13.23100 -28.41000 -4.71000  0.587 49.78268 ? 298 ARG A NE  1 
ATOM   2336 N NE  B ARG A 1 298 ? 12.18700 -27.09800 -7.66100  0.413 47.42414 ? 298 ARG A NE  1 
ATOM   2337 C CZ  A ARG A 1 298 ? 14.54200 -28.27600 -4.86200  0.587 47.79583 ? 298 ARG A CZ  1 
ATOM   2338 C CZ  B ARG A 1 298 ? 13.04200 -27.89300 -8.28500  0.413 46.53544 ? 298 ARG A CZ  1 
ATOM   2339 N NH1 A ARG A 1 298 ? 15.06000 -27.72900 -5.95000  0.587 48.28296 ? 298 ARG A NH1 1 
ATOM   2340 N NH1 B ARG A 1 298 ? 13.94900 -28.58300 -7.61900  0.413 48.22807 ? 298 ARG A NH1 1 
ATOM   2341 N NH2 A ARG A 1 298 ? 15.35400 -28.69500 -3.89600  0.587 43.66667 ? 298 ARG A NH2 1 
ATOM   2342 N NH2 B ARG A 1 298 ? 13.00800 -27.97700 -9.61000  0.413 46.22520 ? 298 ARG A NH2 1 
ATOM   2343 N N   . GLN A 1 299 ? 9.37000  -25.30300 -3.60200  1.000 46.13535 ? 299 GLN A N   1 
ATOM   2344 C CA  . GLN A 1 299 ? 9.69100  -25.03800 -2.20500  1.000 47.20286 ? 299 GLN A CA  1 
ATOM   2345 C C   . GLN A 1 299 ? 8.47500  -24.54000 -1.44900  1.000 54.59703 ? 299 GLN A C   1 
ATOM   2346 O O   . GLN A 1 299 ? 8.32900  -24.82000 -0.25300  1.000 57.16168 ? 299 GLN A O   1 
ATOM   2347 C CB  . GLN A 1 299 ? 10.83800 -24.02800 -2.09300  1.000 45.33443 ? 299 GLN A CB  1 
ATOM   2348 C CG  . GLN A 1 299 ? 11.26500 -23.71900 -0.65400  1.000 46.65653 ? 299 GLN A CG  1 
ATOM   2349 C CD  . GLN A 1 299 ? 12.57100 -22.94900 -0.57300  1.000 41.52030 ? 299 GLN A CD  1 
ATOM   2350 O OE1 . GLN A 1 299 ? 12.88700 -22.34500 0.45400   1.000 39.55724 ? 299 GLN A OE1 1 
ATOM   2351 N NE2 . GLN A 1 299 ? 13.34100 -22.97500 -1.65400  1.000 41.54074 ? 299 GLN A NE2 1 
ATOM   2352 N N   . CYS A 1 300 ? 7.58400  -23.82900 -2.13400  1.000 49.94403 ? 300 CYS A N   1 
ATOM   2353 C CA  . CYS A 1 300 ? 6.40700  -23.28000 -1.48300  1.000 49.66059 ? 300 CYS A CA  1 
ATOM   2354 C C   . CYS A 1 300 ? 5.25100  -24.26900 -1.40200  1.000 52.28503 ? 300 CYS A C   1 
ATOM   2355 O O   . CYS A 1 300 ? 4.24100  -23.95500 -0.76300  1.000 48.73200 ? 300 CYS A O   1 
ATOM   2356 C CB  . CYS A 1 300 ? 5.96300  -22.00400 -2.20200  1.000 39.25220 ? 300 CYS A CB  1 
ATOM   2357 S SG  . CYS A 1 300 ? 7.06800  -20.59600 -1.90500  1.000 55.49414 ? 300 CYS A SG  1 
ATOM   2358 N N   . SER A 1 301 ? 5.37200  -25.44900 -2.01700  1.000 53.06524 ? 301 SER A N   1 
ATOM   2359 C CA  . SER A 1 301 ? 4.35900  -26.48900 -1.90300  1.000 48.15883 ? 301 SER A CA  1 
ATOM   2360 C C   . SER A 1 301 ? 4.88000  -27.78800 -1.30200  1.000 57.47636 ? 301 SER A C   1 
ATOM   2361 O O   . SER A 1 301 ? 4.07500  -28.68800 -1.03600  1.000 59.72219 ? 301 SER A O   1 
ATOM   2362 C CB  . SER A 1 301 ? 3.73800  -26.79800 -3.27500  1.000 53.11118 ? 301 SER A CB  1 
ATOM   2363 O OG  . SER A 1 301 ? 4.57100  -27.66100 -4.03100  1.000 56.71126 ? 301 SER A OG  1 
ATOM   2364 N N   . GLY A 1 302 ? 6.18800  -27.91900 -1.09700  1.000 55.52197 ? 302 GLY A N   1 
ATOM   2365 C CA  . GLY A 1 302 ? 6.74000  -29.08700 -0.43200  1.000 50.70980 ? 302 GLY A CA  1 
ATOM   2366 C C   . GLY A 1 302 ? 6.88500  -30.31900 -1.29700  1.000 55.56647 ? 302 GLY A C   1 
ATOM   2367 O O   . GLY A 1 302 ? 6.57800  -31.42900 -0.84200  1.000 56.49276 ? 302 GLY A O   1 
ATOM   2368 N N   . VAL A 1 303 ? 7.35400  -30.15900 -2.53500  1.000 54.53679 ? 303 VAL A N   1 
ATOM   2369 C CA  . VAL A 1 303 ? 7.52500  -31.29900 -3.43000  1.000 61.03002 ? 303 VAL A CA  1 
ATOM   2370 C C   . VAL A 1 303 ? 8.68200  -32.16100 -2.94200  1.000 56.33319 ? 303 VAL A C   1 
ATOM   2371 O O   . VAL A 1 303 ? 9.77700  -31.65800 -2.65900  1.000 54.44979 ? 303 VAL A O   1 
ATOM   2372 C CB  . VAL A 1 303 ? 7.74900  -30.82000 -4.87300  1.000 60.03631 ? 303 VAL A CB  1 
ATOM   2373 C CG1 . VAL A 1 303 ? 8.39500  -31.91500 -5.71100  1.000 58.54515 ? 303 VAL A CG1 1 
ATOM   2374 C CG2 . VAL A 1 303 ? 6.42900  -30.38300 -5.49700  1.000 52.39073 ? 303 VAL A CG2 1 
ATOM   2375 N N   . THR A 1 304 ? 8.44300  -33.46600 -2.83800  1.000 54.61580 ? 304 THR A N   1 
ATOM   2376 C CA  . THR A 1 304 ? 9.43700  -34.41900 -2.36700  1.000 58.33473 ? 304 THR A CA  1 
ATOM   2377 C C   . THR A 1 304 ? 9.86300  -35.35100 -3.49600  1.000 61.89319 ? 304 THR A C   1 
ATOM   2378 O O   . THR A 1 304 ? 9.27700  -35.36900 -4.58300  1.000 62.11912 ? 304 THR A O   1 
ATOM   2379 C CB  . THR A 1 304 ? 8.89800  -35.22800 -1.17900  1.000 55.87760 ? 304 THR A CB  1 
ATOM   2380 O OG1 . THR A 1 304 ? 7.74100  -35.97000 -1.58400  1.000 66.15037 ? 304 THR A OG1 1 
ATOM   2381 C CG2 . THR A 1 304 ? 8.52100  -34.30300 -0.03600  1.000 53.09628 ? 304 THR A CG2 1 
ATOM   2382 N N   . PHE A 1 305 ? 10.91100 -36.13000 -3.22200  1.000 55.12989 ? 305 PHE A N   1 
ATOM   2383 C CA  . PHE A 1 305 ? 11.46300 -37.08700 -4.17200  1.000 62.16621 ? 305 PHE A CA  1 
ATOM   2384 C C   . PHE A 1 305 ? 11.74000 -38.39100 -3.43100  1.000 61.30410 ? 305 PHE A C   1 
ATOM   2385 O O   . PHE A 1 305 ? 11.48100 -38.51100 -2.23000  1.000 63.63007 ? 305 PHE A O   1 
ATOM   2386 C CB  . PHE A 1 305 ? 12.73000 -36.53400 -4.84300  1.000 61.38671 ? 305 PHE A CB  1 
ATOM   2387 C CG  . PHE A 1 305 ? 12.64200 -35.07300 -5.19500  1.000 57.60012 ? 305 PHE A CG  1 
ATOM   2388 C CD1 . PHE A 1 305 ? 12.01000 -34.66100 -6.35800  1.000 59.45002 ? 305 PHE A CD1 1 
ATOM   2389 C CD2 . PHE A 1 305 ? 13.18400 -34.11200 -4.35600  1.000 55.87232 ? 305 PHE A CD2 1 
ATOM   2390 C CE1 . PHE A 1 305 ? 11.92000 -33.31500 -6.67900  1.000 57.28292 ? 305 PHE A CE1 1 
ATOM   2391 C CE2 . PHE A 1 305 ? 13.09800 -32.76600 -4.67200  1.000 57.34638 ? 305 PHE A CE2 1 
ATOM   2392 C CZ  . PHE A 1 305 ? 12.46500 -32.36800 -5.83600  1.000 56.31064 ? 305 PHE A CZ  1 
ATOM   2393 N N   . GLN A 1 306 ? 12.27000 -39.37800 -4.15100  1.000 60.37913 ? 306 GLN A N   1 
ATOM   2394 C CA  . GLN A 1 306 ? 12.58000 -40.67400 -3.54600  1.000 64.25819 ? 306 GLN A CA  1 
ATOM   2395 C C   . GLN A 1 306 ? 13.75200 -40.57000 -2.57500  1.000 59.64461 ? 306 GLN A C   1 
ATOM   2396 O O   . GLN A 1 306 ? 13.73600 -41.17400 -1.50200  1.000 63.18498 ? 306 GLN A O   1 
ATOM   2397 C CB  . GLN A 1 306 ? 12.89000 -41.72200 -4.61900  1.000 59.26089 ? 306 GLN A CB  1 
ATOM   2398 C CG  . GLN A 1 306 ? 13.12500 -43.12000 -4.05500  1.000 56.37542 ? 306 GLN A CG  1 
ATOM   2399 C CD  . GLN A 1 306 ? 13.22400 -44.18400 -5.13200  1.000 57.22402 ? 306 GLN A CD  1 
ATOM   2400 O OE1 . GLN A 1 306 ? 14.14800 -44.18200 -5.94400  1.000 63.28288 ? 306 GLN A OE1 1 
ATOM   2401 N NE2 . GLN A 1 306 ? 12.26600 -45.10200 -5.14300  1.000 60.97869 ? 306 GLN A NE2 1 
HETATM 2402 C C7  . UED B 2 .   ? 42.34300 -22.05400 -14.35900 1.000 40.06553 ? 401 UED A C7  1 
HETATM 2403 O O8  . UED B 2 .   ? 42.86600 -23.27900 -14.92500 1.000 34.92891 ? 401 UED A O8  1 
HETATM 2404 C C9  . UED B 2 .   ? 42.02200 -24.33000 -14.88500 1.000 39.05886 ? 401 UED A C9  1 
HETATM 2405 O O10 . UED B 2 .   ? 40.95800 -24.34900 -14.30900 1.000 40.02933 ? 401 UED A O10 1 
HETATM 2406 C C1  . UED B 2 .   ? 42.71900 -20.86900 -15.24200 1.000 47.35240 ? 401 UED A C1  1 
HETATM 2407 C C2  . UED B 2 .   ? 43.04600 -21.07000 -16.57300 1.000 50.88564 ? 401 UED A C2  1 
HETATM 2408 C C3  . UED B 2 .   ? 43.38800 -19.98800 -17.37200 1.000 52.24656 ? 401 UED A C3  1 
HETATM 2409 C C4  . UED B 2 .   ? 43.39700 -18.70800 -16.84000 1.000 45.59611 ? 401 UED A C4  1 
HETATM 2410 C C5  . UED B 2 .   ? 43.06500 -18.50900 -15.51000 1.000 44.69024 ? 401 UED A C5  1 
HETATM 2411 C C6  . UED B 2 .   ? 42.72700 -19.58900 -14.71000 1.000 48.24544 ? 401 UED A C6  1 
HETATM 2412 N N11 . UED B 2 .   ? 42.48900 -25.39000 -15.56300 1.000 38.35684 ? 401 UED A N11 1 
HETATM 2413 C C12 . UED B 2 .   ? 41.79000 -26.66100 -15.52300 1.000 33.47908 ? 401 UED A C12 1 
HETATM 2414 C C17 . UED B 2 .   ? 41.72400 -27.18000 -14.09000 1.000 34.15537 ? 401 UED A C17 1 
HETATM 2415 O O18 . UED B 2 .   ? 42.76200 -27.40700 -13.47600 1.000 37.64620 ? 401 UED A O18 1 
HETATM 2416 C C13 . UED B 2 .   ? 42.50400 -27.67400 -16.41400 1.000 32.16936 ? 401 UED A C13 1 
HETATM 2417 C C14 . UED B 2 .   ? 42.33500 -27.27600 -17.87800 1.000 35.78915 ? 401 UED A C14 1 
HETATM 2418 C C15 . UED B 2 .   ? 43.04600 -28.29200 -18.76900 1.000 34.09948 ? 401 UED A C15 1 
HETATM 2419 C C16 . UED B 2 .   ? 40.85000 -27.21500 -18.23200 1.000 37.74130 ? 401 UED A C16 1 
HETATM 2420 N N19 . UED B 2 .   ? 40.53900 -27.38200 -13.51800 1.000 34.90729 ? 401 UED A N19 1 
HETATM 2421 C C20 . UED B 2 .   ? 40.44900 -27.88400 -12.15800 1.000 34.33947 ? 401 UED A C20 1 
HETATM 2422 C C21 . UED B 2 .   ? 40.10000 -29.37000 -12.20900 1.000 35.68454 ? 401 UED A C21 1 
HETATM 2423 O O22 . UED B 2 .   ? 39.97500 -29.87600 -10.90700 1.000 38.55567 ? 401 UED A O22 1 
HETATM 2424 C C24 . UED B 2 .   ? 39.40900 -27.08300 -11.37600 1.000 31.22987 ? 401 UED A C24 1 
HETATM 2425 C C25 . UED B 2 .   ? 39.96500 -25.68700 -11.02300 1.000 38.45943 ? 401 UED A C25 1 
HETATM 2426 C C26 . UED B 2 .   ? 41.15900 -25.63200 -10.05200 1.000 39.83723 ? 401 UED A C26 1 
HETATM 2427 C C27 . UED B 2 .   ? 40.92500 -24.39400 -9.18600  1.000 38.99553 ? 401 UED A C27 1 
HETATM 2428 N N28 . UED B 2 .   ? 39.50600 -24.10900 -9.38100  1.000 38.75838 ? 401 UED A N28 1 
HETATM 2429 C C29 . UED B 2 .   ? 38.92400 -24.78500 -10.37100 1.000 38.04238 ? 401 UED A C29 1 
HETATM 2430 O O30 . UED B 2 .   ? 37.74500 -24.69500 -10.70700 1.000 37.44328 ? 401 UED A O30 1 
HETATM 2431 O O   . HOH C 3 .   ? 28.81000 -39.12200 -22.79400 1.000 36.22525 ? 501 HOH A O   1 
HETATM 2432 O O   . HOH C 3 .   ? 16.14400 -20.93200 -18.49400 1.000 46.33877 ? 502 HOH A O   1 
HETATM 2433 O O   . HOH C 3 .   ? 29.45200 -34.69900 -7.81400  1.000 32.20494 ? 503 HOH A O   1 
HETATM 2434 O O   . HOH C 3 .   ? 2.56100  -3.37100  -7.70500  1.000 51.47383 ? 504 HOH A O   1 
HETATM 2435 O O   . HOH C 3 .   ? 8.38900  -21.75500 3.28500   1.000 45.36523 ? 505 HOH A O   1 
HETATM 2436 O O   . HOH C 3 .   ? 42.51000 -42.98500 -8.87600  1.000 43.75276 ? 506 HOH A O   1 
HETATM 2437 O O   . HOH C 3 .   ? 19.37900 -38.46800 -3.32000  1.000 40.38944 ? 507 HOH A O   1 
HETATM 2438 O O   . HOH C 3 .   ? 14.12000 -29.37700 -11.41700 1.000 47.79188 ? 508 HOH A O   1 
HETATM 2439 O O   . HOH C 3 .   ? 44.28000 -44.34100 -26.42900 1.000 38.84722 ? 509 HOH A O   1 
HETATM 2440 O O   . HOH C 3 .   ? 15.14000 -36.04700 -13.38100 1.000 41.74164 ? 510 HOH A O   1 
HETATM 2441 O O   . HOH C 3 .   ? 11.48900 -7.69600  4.14500   1.000 48.21347 ? 511 HOH A O   1 
HETATM 2442 O O   . HOH C 3 .   ? 24.69900 -32.56600 -25.44300 1.000 43.52414 ? 512 HOH A O   1 
HETATM 2443 O O   . HOH C 3 .   ? 42.89500 -31.91800 -28.92000 1.000 41.34052 ? 513 HOH A O   1 
HETATM 2444 O O   . HOH C 3 .   ? 50.28200 -47.75000 -23.08800 1.000 44.86924 ? 514 HOH A O   1 
HETATM 2445 O O   . HOH C 3 .   ? 10.47100 5.13800   -10.27500 1.000 52.11259 ? 515 HOH A O   1 
HETATM 2446 O O   . HOH C 3 .   ? 41.45500 -49.33400 -11.63500 1.000 48.73244 ? 516 HOH A O   1 
HETATM 2447 O O   . HOH C 3 .   ? 24.45300 -33.97100 -19.86100 1.000 28.81492 ? 517 HOH A O   1 
HETATM 2448 O O   . HOH C 3 .   ? 19.31200 -31.63300 -14.73000 1.000 36.42168 ? 518 HOH A O   1 
HETATM 2449 O O   . HOH C 3 .   ? 23.00900 -0.03100  -15.77900 1.000 50.41753 ? 519 HOH A O   1 
HETATM 2450 O O   . HOH C 3 .   ? 45.97800 -51.85700 -20.97900 1.000 35.43864 ? 520 HOH A O   1 
HETATM 2451 O O   . HOH C 3 .   ? 37.63700 -27.81500 -25.64300 1.000 34.15316 ? 521 HOH A O   1 
HETATM 2452 O O   . HOH C 3 .   ? 25.75100 -19.71100 -10.95500 1.000 33.25363 ? 522 HOH A O   1 
HETATM 2453 O O   . HOH C 3 .   ? 15.55400 -15.88600 -8.21500  1.000 35.60264 ? 523 HOH A O   1 
HETATM 2454 O O   . HOH C 3 .   ? 19.01200 -16.97400 -21.10100 1.000 48.85471 ? 524 HOH A O   1 
HETATM 2455 O O   . HOH C 3 .   ? 14.28800 -25.73800 -11.64200 1.000 41.28039 ? 525 HOH A O   1 
HETATM 2456 O O   . HOH C 3 .   ? 30.56200 -23.53000 -18.70900 1.000 27.39585 ? 526 HOH A O   1 
HETATM 2457 O O   . HOH C 3 .   ? 45.96300 -35.26300 -33.87500 1.000 47.78946 ? 527 HOH A O   1 
HETATM 2458 O O   . HOH C 3 .   ? 22.14300 -24.99700 -23.42000 1.000 34.97849 ? 528 HOH A O   1 
HETATM 2459 O O   . HOH C 3 .   ? 25.29900 -41.92400 1.16900   1.000 40.08027 ? 529 HOH A O   1 
HETATM 2460 O O   . HOH C 3 .   ? 35.08800 -43.46300 -4.23400  1.000 43.73514 ? 530 HOH A O   1 
HETATM 2461 O O   . HOH C 3 .   ? 38.79600 -31.51200 -19.77800 1.000 30.04294 ? 531 HOH A O   1 
HETATM 2462 O O   . HOH C 3 .   ? 23.32200 -51.77600 -11.74600 1.000 43.80443 ? 532 HOH A O   1 
HETATM 2463 O O   . HOH C 3 .   ? 19.340   6.763     -14.555   1.000 39.42929 ? 533 HOH A O   1 
HETATM 2464 O O   . HOH C 3 .   ? 20.42800 -39.91500 -21.51200 1.000 38.54315 ? 534 HOH A O   1 
HETATM 2465 O O   . HOH C 3 .   ? 25.67400 -19.47000 -7.50800  1.000 37.55825 ? 535 HOH A O   1 
HETATM 2466 O O   . HOH C 3 .   ? 16.56800 -44.42200 -8.61000  1.000 51.51397 ? 536 HOH A O   1 
HETATM 2467 O O   . HOH C 3 .   ? 43.21400 -40.21800 -29.14000 1.000 39.14796 ? 537 HOH A O   1 
HETATM 2468 O O   . HOH C 3 .   ? 30.24400 -15.04400 -15.27900 1.000 33.20741 ? 538 HOH A O   1 
HETATM 2469 O O   . HOH C 3 .   ? 33.87400 -36.81500 -29.69800 1.000 39.31230 ? 539 HOH A O   1 
HETATM 2470 O O   . HOH C 3 .   ? 15.98300 -26.24200 -13.36600 1.000 41.09320 ? 540 HOH A O   1 
HETATM 2471 O O   . HOH C 3 .   ? 32.96300 -24.08300 -26.93100 1.000 42.39023 ? 541 HOH A O   1 
HETATM 2472 O O   . HOH C 3 .   ? -2.87700 -7.56100  -9.60200  1.000 54.79440 ? 542 HOH A O   1 
HETATM 2473 O O   . HOH C 3 .   ? 40.73000 -13.44000 -22.23900 1.000 47.15412 ? 543 HOH A O   1 
HETATM 2474 O O   . HOH C 3 .   ? 22.27300 -25.01200 -1.41200  1.000 37.97844 ? 544 HOH A O   1 
HETATM 2475 O O   . HOH C 3 .   ? 29.23600 -45.40400 -24.62700 1.000 57.48757 ? 545 HOH A O   1 
HETATM 2476 O O   . HOH C 3 .   ? 13.52400 -9.80400  4.71800   1.000 43.09757 ? 546 HOH A O   1 
HETATM 2477 O O   . HOH C 3 .   ? 19.83700 -5.97100  -9.75300  1.000 39.35454 ? 547 HOH A O   1 
HETATM 2478 O O   . HOH C 3 .   ? -1.95900 -21.34400 -9.79700  1.000 39.10957 ? 548 HOH A O   1 
HETATM 2479 O O   . HOH C 3 .   ? 14.34300 -19.74500 -15.86300 1.000 37.39921 ? 549 HOH A O   1 
HETATM 2480 O O   . HOH C 3 .   ? 5.19700  -37.21500 -0.56600  1.000 42.65369 ? 550 HOH A O   1 
HETATM 2481 O O   . HOH C 3 .   ? 16.61600 -14.57900 -0.82900  1.000 42.81247 ? 551 HOH A O   1 
HETATM 2482 O O   . HOH C 3 .   ? 38.78100 -42.01000 -28.45700 1.000 38.24365 ? 552 HOH A O   1 
HETATM 2483 O O   . HOH C 3 .   ? 21.49500 -16.73200 -22.79900 1.000 47.78449 ? 553 HOH A O   1 
HETATM 2484 O O   . HOH C 3 .   ? 40.42500 -46.70000 -27.78800 1.000 39.14525 ? 554 HOH A O   1 
HETATM 2485 O O   . HOH C 3 .   ? 44.11700 -50.54400 -23.83400 1.000 33.42786 ? 555 HOH A O   1 
HETATM 2486 O O   . HOH C 3 .   ? 25.55000 -51.83200 -18.35700 1.000 46.08444 ? 556 HOH A O   1 
HETATM 2487 O O   . HOH C 3 .   ? 34.63500 -27.36400 -26.37100 1.000 36.98713 ? 557 HOH A O   1 
HETATM 2488 O O   . HOH C 3 .   ? 41.65600 -54.60600 -21.12300 1.000 44.57497 ? 558 HOH A O   1 
HETATM 2489 O O   . HOH C 3 .   ? 20.63300 -6.28400  -7.20300  1.000 45.11492 ? 559 HOH A O   1 
HETATM 2490 O O   . HOH C 3 .   ? 40.66200 -44.01900 -27.12300 1.000 41.07543 ? 560 HOH A O   1 
HETATM 2491 O O   . HOH C 3 .   ? 40.07700 -48.95500 -25.72300 1.000 43.86683 ? 561 HOH A O   1 
HETATM 2492 O O   . HOH C 3 .   ? 26.61600 -23.14700 -25.68600 1.000 39.76896 ? 562 HOH A O   1 
HETATM 2493 O O   . HOH C 3 .   ? 32.34500 -12.94800 -15.62800 1.000 49.42782 ? 563 HOH A O   1 
HETATM 2494 O O   . HOH C 3 .   ? 23.74700 -24.27100 -25.71500 1.000 40.84908 ? 564 HOH A O   1 
HETATM 2495 O O   . HOH C 3 .   ? 40.59200 -29.99600 -28.95500 1.000 42.56440 ? 565 HOH A O   1 
HETATM 2496 O O   . HOH C 3 .   ? 3.963    -21.251   7.742     1.000 46.61042 ? 566 HOH A O   1 
HETATM 2497 O O   . HOH C 3 .   ? 23.59200 -34.08000 -22.71200 1.000 40.92777 ? 567 HOH A O   1 
HETATM 2498 O O   . HOH C 3 .   ? 42.25000 -50.35600 -25.76500 1.000 35.97140 ? 568 HOH A O   1 
HETATM 2499 O O   . HOH C 3 .   ? 44.35100 -53.70600 -19.40200 1.000 42.41294 ? 569 HOH A O   1 
HETATM 2500 O O   . HOH C 3 .   ? 39.97600 -27.55700 -27.63400 1.000 34.96417 ? 570 HOH A O   1 
HETATM 2501 O O   . HOH C 3 .   ? 45.39300 -52.43300 -23.36000 1.000 41.22569 ? 571 HOH A O   1 
HETATM 2502 O O   . HOH C 3 .   ? 35.553   -16.599   -26.798   1.000 34.49416 ? 572 HOH A O   1 
HETATM 2503 O O   . HOH C 3 .   ? 13.14200 -9.90900  7.59400   1.000 38.87711 ? 573 HOH A O   1 
# 
