data_9EDP
# 
_entry.id   9EDP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EDP         pdb_00009edp 10.2210/pdb9edp/pdb 
WWPDB D_1000290128 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-05 ? 
2 'Structure model' 1 1 2025-03-19 ? 
3 'Structure model' 1 2 2025-04-23 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 3 'Structure model' '_citation.journal_volume'          
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EDP 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              g.hansman@griffith.edu.au 
_pdbx_contact_author.name_first         Grant 
_pdbx_contact_author.name_last          Hansman 
_pdbx_contact_author.name_mi            S. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8735-4618 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Holroyd, D.L.' 1 0009-0002-2830-6020 
'Kumar, A.'     2 0000-0001-7540-6177 
'Bruning, J.B.' 3 0000-0002-6919-1824 
'Hansman, G.S.' 4 0000-0001-8735-4618 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Virol. 
_citation.journal_id_ASTM           JOVIAM 
_citation.journal_id_CSD            0825 
_citation.journal_id_ISSN           1098-5514 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            99 
_citation.language                  ? 
_citation.page_first                e0197124 
_citation.page_last                 e0197124 
_citation.title                     'Antigenic structural analysis of bat and human norovirus protruding (P) domains.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1128/jvi.01971-24 
_citation.pdbx_database_id_PubMed   40062838 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Holroyd, D.L.'    1 0009-0002-2830-6020 
primary 'Kumar, A.'        2 0000-0001-7540-6177 
primary 'Vasquez, E.'      3 ?                   
primary 'Masic, V.'        4 ?                   
primary 'von Itzstein, M.' 5 0000-0001-6302-7524 
primary 'Bruning, J.B.'    6 0000-0002-6919-1824 
primary 'Hansman, G.S.'    7 0000-0001-8735-4618 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man VP1            35629.793 1   ? ? 'protruding domain' ? 
2 non-polymer syn 'CHLORIDE ION' 35.453    1   ? ? ?                   ? 
3 water       nat water          18.015    665 ? ? ?                   ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSTPFTLPRLPISEMTNSRFPLVIKGMVVDPNLPLQANFQNGRITLDGELQGTTLPTSTSIGRISGTYMSSTPSRIIQHE
DSGDSTQPRVFNPVWMDLTENNWTEFQPFNDQPAPLGCPDFKAKILGTLIRQPNNGSYYFDAYLDTRQHGTFAPYTGHAA
VHSDQQAGHLAQGYKIQFSPTGIESDQNTDLNQLPDYGGAMTVSKGLAPAAAPDFPGEMILYFVSDMPVRNPNGERRDTE
ILCLLPQEMVTHFYEQQAPSQGDVALVRYINAETGRVMFEGKLHRNGFFTVSATARTLIVPDGYFRFDSWVNRFYTLSPM
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSTPFTLPRLPISEMTNSRFPLVIKGMVVDPNLPLQANFQNGRITLDGELQGTTLPTSTSIGRISGTYMSSTPSRIIQHE
DSGDSTQPRVFNPVWMDLTENNWTEFQPFNDQPAPLGCPDFKAKILGTLIRQPNNGSYYFDAYLDTRQHGTFAPYTGHAA
VHSDQQAGHLAQGYKIQFSPTGIESDQNTDLNQLPDYGGAMTVSKGLAPAAAPDFPGEMILYFVSDMPVRNPNGERRDTE
ILCLLPQEMVTHFYEQQAPSQGDVALVRYINAETGRVMFEGKLHRNGFFTVSATARTLIVPDGYFRFDSWVNRFYTLSPM
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CHLORIDE ION' CL  
3 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   THR n 
1 4   PRO n 
1 5   PHE n 
1 6   THR n 
1 7   LEU n 
1 8   PRO n 
1 9   ARG n 
1 10  LEU n 
1 11  PRO n 
1 12  ILE n 
1 13  SER n 
1 14  GLU n 
1 15  MET n 
1 16  THR n 
1 17  ASN n 
1 18  SER n 
1 19  ARG n 
1 20  PHE n 
1 21  PRO n 
1 22  LEU n 
1 23  VAL n 
1 24  ILE n 
1 25  LYS n 
1 26  GLY n 
1 27  MET n 
1 28  VAL n 
1 29  VAL n 
1 30  ASP n 
1 31  PRO n 
1 32  ASN n 
1 33  LEU n 
1 34  PRO n 
1 35  LEU n 
1 36  GLN n 
1 37  ALA n 
1 38  ASN n 
1 39  PHE n 
1 40  GLN n 
1 41  ASN n 
1 42  GLY n 
1 43  ARG n 
1 44  ILE n 
1 45  THR n 
1 46  LEU n 
1 47  ASP n 
1 48  GLY n 
1 49  GLU n 
1 50  LEU n 
1 51  GLN n 
1 52  GLY n 
1 53  THR n 
1 54  THR n 
1 55  LEU n 
1 56  PRO n 
1 57  THR n 
1 58  SER n 
1 59  THR n 
1 60  SER n 
1 61  ILE n 
1 62  GLY n 
1 63  ARG n 
1 64  ILE n 
1 65  SER n 
1 66  GLY n 
1 67  THR n 
1 68  TYR n 
1 69  MET n 
1 70  SER n 
1 71  SER n 
1 72  THR n 
1 73  PRO n 
1 74  SER n 
1 75  ARG n 
1 76  ILE n 
1 77  ILE n 
1 78  GLN n 
1 79  HIS n 
1 80  GLU n 
1 81  ASP n 
1 82  SER n 
1 83  GLY n 
1 84  ASP n 
1 85  SER n 
1 86  THR n 
1 87  GLN n 
1 88  PRO n 
1 89  ARG n 
1 90  VAL n 
1 91  PHE n 
1 92  ASN n 
1 93  PRO n 
1 94  VAL n 
1 95  TRP n 
1 96  MET n 
1 97  ASP n 
1 98  LEU n 
1 99  THR n 
1 100 GLU n 
1 101 ASN n 
1 102 ASN n 
1 103 TRP n 
1 104 THR n 
1 105 GLU n 
1 106 PHE n 
1 107 GLN n 
1 108 PRO n 
1 109 PHE n 
1 110 ASN n 
1 111 ASP n 
1 112 GLN n 
1 113 PRO n 
1 114 ALA n 
1 115 PRO n 
1 116 LEU n 
1 117 GLY n 
1 118 CYS n 
1 119 PRO n 
1 120 ASP n 
1 121 PHE n 
1 122 LYS n 
1 123 ALA n 
1 124 LYS n 
1 125 ILE n 
1 126 LEU n 
1 127 GLY n 
1 128 THR n 
1 129 LEU n 
1 130 ILE n 
1 131 ARG n 
1 132 GLN n 
1 133 PRO n 
1 134 ASN n 
1 135 ASN n 
1 136 GLY n 
1 137 SER n 
1 138 TYR n 
1 139 TYR n 
1 140 PHE n 
1 141 ASP n 
1 142 ALA n 
1 143 TYR n 
1 144 LEU n 
1 145 ASP n 
1 146 THR n 
1 147 ARG n 
1 148 GLN n 
1 149 HIS n 
1 150 GLY n 
1 151 THR n 
1 152 PHE n 
1 153 ALA n 
1 154 PRO n 
1 155 TYR n 
1 156 THR n 
1 157 GLY n 
1 158 HIS n 
1 159 ALA n 
1 160 ALA n 
1 161 VAL n 
1 162 HIS n 
1 163 SER n 
1 164 ASP n 
1 165 GLN n 
1 166 GLN n 
1 167 ALA n 
1 168 GLY n 
1 169 HIS n 
1 170 LEU n 
1 171 ALA n 
1 172 GLN n 
1 173 GLY n 
1 174 TYR n 
1 175 LYS n 
1 176 ILE n 
1 177 GLN n 
1 178 PHE n 
1 179 SER n 
1 180 PRO n 
1 181 THR n 
1 182 GLY n 
1 183 ILE n 
1 184 GLU n 
1 185 SER n 
1 186 ASP n 
1 187 GLN n 
1 188 ASN n 
1 189 THR n 
1 190 ASP n 
1 191 LEU n 
1 192 ASN n 
1 193 GLN n 
1 194 LEU n 
1 195 PRO n 
1 196 ASP n 
1 197 TYR n 
1 198 GLY n 
1 199 GLY n 
1 200 ALA n 
1 201 MET n 
1 202 THR n 
1 203 VAL n 
1 204 SER n 
1 205 LYS n 
1 206 GLY n 
1 207 LEU n 
1 208 ALA n 
1 209 PRO n 
1 210 ALA n 
1 211 ALA n 
1 212 ALA n 
1 213 PRO n 
1 214 ASP n 
1 215 PHE n 
1 216 PRO n 
1 217 GLY n 
1 218 GLU n 
1 219 MET n 
1 220 ILE n 
1 221 LEU n 
1 222 TYR n 
1 223 PHE n 
1 224 VAL n 
1 225 SER n 
1 226 ASP n 
1 227 MET n 
1 228 PRO n 
1 229 VAL n 
1 230 ARG n 
1 231 ASN n 
1 232 PRO n 
1 233 ASN n 
1 234 GLY n 
1 235 GLU n 
1 236 ARG n 
1 237 ARG n 
1 238 ASP n 
1 239 THR n 
1 240 GLU n 
1 241 ILE n 
1 242 LEU n 
1 243 CYS n 
1 244 LEU n 
1 245 LEU n 
1 246 PRO n 
1 247 GLN n 
1 248 GLU n 
1 249 MET n 
1 250 VAL n 
1 251 THR n 
1 252 HIS n 
1 253 PHE n 
1 254 TYR n 
1 255 GLU n 
1 256 GLN n 
1 257 GLN n 
1 258 ALA n 
1 259 PRO n 
1 260 SER n 
1 261 GLN n 
1 262 GLY n 
1 263 ASP n 
1 264 VAL n 
1 265 ALA n 
1 266 LEU n 
1 267 VAL n 
1 268 ARG n 
1 269 TYR n 
1 270 ILE n 
1 271 ASN n 
1 272 ALA n 
1 273 GLU n 
1 274 THR n 
1 275 GLY n 
1 276 ARG n 
1 277 VAL n 
1 278 MET n 
1 279 PHE n 
1 280 GLU n 
1 281 GLY n 
1 282 LYS n 
1 283 LEU n 
1 284 HIS n 
1 285 ARG n 
1 286 ASN n 
1 287 GLY n 
1 288 PHE n 
1 289 PHE n 
1 290 THR n 
1 291 VAL n 
1 292 SER n 
1 293 ALA n 
1 294 THR n 
1 295 ALA n 
1 296 ARG n 
1 297 THR n 
1 298 LEU n 
1 299 ILE n 
1 300 VAL n 
1 301 PRO n 
1 302 ASP n 
1 303 GLY n 
1 304 TYR n 
1 305 PHE n 
1 306 ARG n 
1 307 PHE n 
1 308 ASP n 
1 309 SER n 
1 310 TRP n 
1 311 VAL n 
1 312 ASN n 
1 313 ARG n 
1 314 PHE n 
1 315 TYR n 
1 316 THR n 
1 317 LEU n 
1 318 SER n 
1 319 PRO n 
1 320 MET n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   320 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    GVIII 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Chiba-040502 virus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2759888 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   223 223 GLY GLY A . n 
A 1 2   SER 2   224 224 SER SER A . n 
A 1 3   THR 3   225 225 THR THR A . n 
A 1 4   PRO 4   226 226 PRO PRO A . n 
A 1 5   PHE 5   227 227 PHE PHE A . n 
A 1 6   THR 6   228 228 THR THR A . n 
A 1 7   LEU 7   229 229 LEU LEU A . n 
A 1 8   PRO 8   230 230 PRO PRO A . n 
A 1 9   ARG 9   231 231 ARG ARG A . n 
A 1 10  LEU 10  232 232 LEU LEU A . n 
A 1 11  PRO 11  233 233 PRO PRO A . n 
A 1 12  ILE 12  234 234 ILE ILE A . n 
A 1 13  SER 13  235 235 SER SER A . n 
A 1 14  GLU 14  236 236 GLU GLU A . n 
A 1 15  MET 15  237 237 MET MET A . n 
A 1 16  THR 16  238 238 THR THR A . n 
A 1 17  ASN 17  239 239 ASN ASN A . n 
A 1 18  SER 18  240 240 SER SER A . n 
A 1 19  ARG 19  241 241 ARG ARG A . n 
A 1 20  PHE 20  242 242 PHE PHE A . n 
A 1 21  PRO 21  243 243 PRO PRO A . n 
A 1 22  LEU 22  244 244 LEU LEU A . n 
A 1 23  VAL 23  245 245 VAL VAL A . n 
A 1 24  ILE 24  246 246 ILE ILE A . n 
A 1 25  LYS 25  247 247 LYS LYS A . n 
A 1 26  GLY 26  248 248 GLY GLY A . n 
A 1 27  MET 27  249 249 MET MET A . n 
A 1 28  VAL 28  250 250 VAL VAL A . n 
A 1 29  VAL 29  251 251 VAL VAL A . n 
A 1 30  ASP 30  252 252 ASP ASP A . n 
A 1 31  PRO 31  253 253 PRO PRO A . n 
A 1 32  ASN 32  254 254 ASN ASN A . n 
A 1 33  LEU 33  255 255 LEU LEU A . n 
A 1 34  PRO 34  256 256 PRO PRO A . n 
A 1 35  LEU 35  257 257 LEU LEU A . n 
A 1 36  GLN 36  258 258 GLN GLN A . n 
A 1 37  ALA 37  259 259 ALA ALA A . n 
A 1 38  ASN 38  260 260 ASN ASN A . n 
A 1 39  PHE 39  261 261 PHE PHE A . n 
A 1 40  GLN 40  262 262 GLN GLN A . n 
A 1 41  ASN 41  263 263 ASN ASN A . n 
A 1 42  GLY 42  264 264 GLY GLY A . n 
A 1 43  ARG 43  265 265 ARG ARG A . n 
A 1 44  ILE 44  266 266 ILE ILE A . n 
A 1 45  THR 45  267 267 THR THR A . n 
A 1 46  LEU 46  268 268 LEU LEU A . n 
A 1 47  ASP 47  269 269 ASP ASP A . n 
A 1 48  GLY 48  270 270 GLY GLY A . n 
A 1 49  GLU 49  271 271 GLU GLU A . n 
A 1 50  LEU 50  272 272 LEU LEU A . n 
A 1 51  GLN 51  273 273 GLN GLN A . n 
A 1 52  GLY 52  274 274 GLY GLY A . n 
A 1 53  THR 53  275 275 THR THR A . n 
A 1 54  THR 54  276 276 THR THR A . n 
A 1 55  LEU 55  277 277 LEU LEU A . n 
A 1 56  PRO 56  278 278 PRO PRO A . n 
A 1 57  THR 57  279 279 THR THR A . n 
A 1 58  SER 58  280 280 SER SER A . n 
A 1 59  THR 59  281 281 THR THR A . n 
A 1 60  SER 60  282 282 SER SER A . n 
A 1 61  ILE 61  283 283 ILE ILE A . n 
A 1 62  GLY 62  284 284 GLY GLY A . n 
A 1 63  ARG 63  285 285 ARG ARG A . n 
A 1 64  ILE 64  286 286 ILE ILE A . n 
A 1 65  SER 65  287 287 SER SER A . n 
A 1 66  GLY 66  288 288 GLY GLY A . n 
A 1 67  THR 67  289 289 THR THR A . n 
A 1 68  TYR 68  290 290 TYR TYR A . n 
A 1 69  MET 69  291 291 MET MET A . n 
A 1 70  SER 70  292 292 SER SER A . n 
A 1 71  SER 71  293 293 SER SER A . n 
A 1 72  THR 72  294 294 THR THR A . n 
A 1 73  PRO 73  295 295 PRO PRO A . n 
A 1 74  SER 74  296 ?   ?   ?   A . n 
A 1 75  ARG 75  297 ?   ?   ?   A . n 
A 1 76  ILE 76  298 ?   ?   ?   A . n 
A 1 77  ILE 77  299 ?   ?   ?   A . n 
A 1 78  GLN 78  300 ?   ?   ?   A . n 
A 1 79  HIS 79  301 ?   ?   ?   A . n 
A 1 80  GLU 80  302 ?   ?   ?   A . n 
A 1 81  ASP 81  303 ?   ?   ?   A . n 
A 1 82  SER 82  304 ?   ?   ?   A . n 
A 1 83  GLY 83  305 ?   ?   ?   A . n 
A 1 84  ASP 84  306 ?   ?   ?   A . n 
A 1 85  SER 85  307 ?   ?   ?   A . n 
A 1 86  THR 86  308 ?   ?   ?   A . n 
A 1 87  GLN 87  309 ?   ?   ?   A . n 
A 1 88  PRO 88  310 ?   ?   ?   A . n 
A 1 89  ARG 89  311 311 ARG ARG A . n 
A 1 90  VAL 90  312 312 VAL VAL A . n 
A 1 91  PHE 91  313 313 PHE PHE A . n 
A 1 92  ASN 92  314 314 ASN ASN A . n 
A 1 93  PRO 93  315 315 PRO PRO A . n 
A 1 94  VAL 94  316 316 VAL VAL A . n 
A 1 95  TRP 95  317 317 TRP TRP A . n 
A 1 96  MET 96  318 318 MET MET A . n 
A 1 97  ASP 97  319 319 ASP ASP A . n 
A 1 98  LEU 98  320 320 LEU LEU A . n 
A 1 99  THR 99  321 321 THR THR A . n 
A 1 100 GLU 100 322 322 GLU GLU A . n 
A 1 101 ASN 101 323 323 ASN ASN A . n 
A 1 102 ASN 102 324 324 ASN ASN A . n 
A 1 103 TRP 103 325 325 TRP TRP A . n 
A 1 104 THR 104 326 326 THR THR A . n 
A 1 105 GLU 105 327 327 GLU GLU A . n 
A 1 106 PHE 106 328 328 PHE PHE A . n 
A 1 107 GLN 107 329 329 GLN GLN A . n 
A 1 108 PRO 108 330 330 PRO PRO A . n 
A 1 109 PHE 109 331 331 PHE PHE A . n 
A 1 110 ASN 110 332 332 ASN ASN A . n 
A 1 111 ASP 111 333 333 ASP ASP A . n 
A 1 112 GLN 112 334 334 GLN GLN A . n 
A 1 113 PRO 113 335 335 PRO PRO A . n 
A 1 114 ALA 114 336 336 ALA ALA A . n 
A 1 115 PRO 115 337 337 PRO PRO A . n 
A 1 116 LEU 116 338 338 LEU LEU A . n 
A 1 117 GLY 117 339 339 GLY GLY A . n 
A 1 118 CYS 118 340 340 CYS CYS A . n 
A 1 119 PRO 119 341 341 PRO PRO A . n 
A 1 120 ASP 120 342 342 ASP ASP A . n 
A 1 121 PHE 121 343 343 PHE PHE A . n 
A 1 122 LYS 122 344 344 LYS LYS A . n 
A 1 123 ALA 123 345 345 ALA ALA A . n 
A 1 124 LYS 124 346 346 LYS LYS A . n 
A 1 125 ILE 125 347 347 ILE ILE A . n 
A 1 126 LEU 126 348 348 LEU LEU A . n 
A 1 127 GLY 127 349 349 GLY GLY A . n 
A 1 128 THR 128 350 350 THR THR A . n 
A 1 129 LEU 129 351 351 LEU LEU A . n 
A 1 130 ILE 130 352 352 ILE ILE A . n 
A 1 131 ARG 131 353 353 ARG ARG A . n 
A 1 132 GLN 132 354 354 GLN GLN A . n 
A 1 133 PRO 133 355 355 PRO PRO A . n 
A 1 134 ASN 134 356 356 ASN ASN A . n 
A 1 135 ASN 135 357 357 ASN ASN A . n 
A 1 136 GLY 136 358 358 GLY GLY A . n 
A 1 137 SER 137 359 359 SER SER A . n 
A 1 138 TYR 138 360 360 TYR TYR A . n 
A 1 139 TYR 139 361 361 TYR TYR A . n 
A 1 140 PHE 140 362 362 PHE PHE A . n 
A 1 141 ASP 141 363 363 ASP ASP A . n 
A 1 142 ALA 142 364 364 ALA ALA A . n 
A 1 143 TYR 143 365 365 TYR TYR A . n 
A 1 144 LEU 144 366 366 LEU LEU A . n 
A 1 145 ASP 145 367 367 ASP ASP A . n 
A 1 146 THR 146 368 368 THR THR A . n 
A 1 147 ARG 147 369 369 ARG ARG A . n 
A 1 148 GLN 148 370 370 GLN GLN A . n 
A 1 149 HIS 149 371 371 HIS HIS A . n 
A 1 150 GLY 150 372 372 GLY GLY A . n 
A 1 151 THR 151 373 373 THR THR A . n 
A 1 152 PHE 152 374 374 PHE PHE A . n 
A 1 153 ALA 153 375 375 ALA ALA A . n 
A 1 154 PRO 154 376 376 PRO PRO A . n 
A 1 155 TYR 155 377 377 TYR TYR A . n 
A 1 156 THR 156 378 378 THR THR A . n 
A 1 157 GLY 157 379 379 GLY GLY A . n 
A 1 158 HIS 158 380 380 HIS HIS A . n 
A 1 159 ALA 159 381 381 ALA ALA A . n 
A 1 160 ALA 160 382 382 ALA ALA A . n 
A 1 161 VAL 161 383 383 VAL VAL A . n 
A 1 162 HIS 162 384 384 HIS HIS A . n 
A 1 163 SER 163 385 385 SER SER A . n 
A 1 164 ASP 164 386 386 ASP ASP A . n 
A 1 165 GLN 165 387 387 GLN GLN A . n 
A 1 166 GLN 166 388 388 GLN GLN A . n 
A 1 167 ALA 167 389 389 ALA ALA A . n 
A 1 168 GLY 168 390 390 GLY GLY A . n 
A 1 169 HIS 169 391 391 HIS HIS A . n 
A 1 170 LEU 170 392 392 LEU LEU A . n 
A 1 171 ALA 171 393 393 ALA ALA A . n 
A 1 172 GLN 172 394 394 GLN GLN A . n 
A 1 173 GLY 173 395 395 GLY GLY A . n 
A 1 174 TYR 174 396 396 TYR TYR A . n 
A 1 175 LYS 175 397 397 LYS LYS A . n 
A 1 176 ILE 176 398 398 ILE ILE A . n 
A 1 177 GLN 177 399 399 GLN GLN A . n 
A 1 178 PHE 178 400 400 PHE PHE A . n 
A 1 179 SER 179 401 401 SER SER A . n 
A 1 180 PRO 180 402 402 PRO PRO A . n 
A 1 181 THR 181 403 403 THR THR A . n 
A 1 182 GLY 182 404 404 GLY GLY A . n 
A 1 183 ILE 183 405 405 ILE ILE A . n 
A 1 184 GLU 184 406 406 GLU GLU A . n 
A 1 185 SER 185 407 407 SER SER A . n 
A 1 186 ASP 186 408 408 ASP ASP A . n 
A 1 187 GLN 187 409 409 GLN GLN A . n 
A 1 188 ASN 188 410 410 ASN ASN A . n 
A 1 189 THR 189 411 411 THR THR A . n 
A 1 190 ASP 190 412 412 ASP ASP A . n 
A 1 191 LEU 191 413 413 LEU LEU A . n 
A 1 192 ASN 192 414 414 ASN ASN A . n 
A 1 193 GLN 193 415 415 GLN GLN A . n 
A 1 194 LEU 194 416 416 LEU LEU A . n 
A 1 195 PRO 195 417 417 PRO PRO A . n 
A 1 196 ASP 196 418 418 ASP ASP A . n 
A 1 197 TYR 197 419 419 TYR TYR A . n 
A 1 198 GLY 198 420 420 GLY GLY A . n 
A 1 199 GLY 199 421 421 GLY GLY A . n 
A 1 200 ALA 200 422 422 ALA ALA A . n 
A 1 201 MET 201 423 423 MET MET A . n 
A 1 202 THR 202 424 424 THR THR A . n 
A 1 203 VAL 203 425 425 VAL VAL A . n 
A 1 204 SER 204 426 426 SER SER A . n 
A 1 205 LYS 205 427 427 LYS LYS A . n 
A 1 206 GLY 206 428 428 GLY GLY A . n 
A 1 207 LEU 207 429 429 LEU LEU A . n 
A 1 208 ALA 208 430 430 ALA ALA A . n 
A 1 209 PRO 209 431 431 PRO PRO A . n 
A 1 210 ALA 210 432 432 ALA ALA A . n 
A 1 211 ALA 211 433 433 ALA ALA A . n 
A 1 212 ALA 212 434 434 ALA ALA A . n 
A 1 213 PRO 213 435 435 PRO PRO A . n 
A 1 214 ASP 214 436 436 ASP ASP A . n 
A 1 215 PHE 215 437 437 PHE PHE A . n 
A 1 216 PRO 216 438 438 PRO PRO A . n 
A 1 217 GLY 217 439 439 GLY GLY A . n 
A 1 218 GLU 218 440 440 GLU GLU A . n 
A 1 219 MET 219 441 441 MET MET A . n 
A 1 220 ILE 220 442 442 ILE ILE A . n 
A 1 221 LEU 221 443 443 LEU LEU A . n 
A 1 222 TYR 222 444 444 TYR TYR A . n 
A 1 223 PHE 223 445 445 PHE PHE A . n 
A 1 224 VAL 224 446 446 VAL VAL A . n 
A 1 225 SER 225 447 447 SER SER A . n 
A 1 226 ASP 226 448 448 ASP ASP A . n 
A 1 227 MET 227 449 449 MET MET A . n 
A 1 228 PRO 228 450 450 PRO PRO A . n 
A 1 229 VAL 229 451 451 VAL VAL A . n 
A 1 230 ARG 230 452 452 ARG ARG A . n 
A 1 231 ASN 231 453 453 ASN ASN A . n 
A 1 232 PRO 232 454 454 PRO PRO A . n 
A 1 233 ASN 233 455 455 ASN ASN A . n 
A 1 234 GLY 234 456 456 GLY GLY A . n 
A 1 235 GLU 235 457 457 GLU GLU A . n 
A 1 236 ARG 236 458 458 ARG ARG A . n 
A 1 237 ARG 237 459 459 ARG ARG A . n 
A 1 238 ASP 238 460 460 ASP ASP A . n 
A 1 239 THR 239 461 461 THR THR A . n 
A 1 240 GLU 240 462 462 GLU GLU A . n 
A 1 241 ILE 241 463 463 ILE ILE A . n 
A 1 242 LEU 242 464 464 LEU LEU A . n 
A 1 243 CYS 243 465 465 CYS CYS A . n 
A 1 244 LEU 244 466 466 LEU LEU A . n 
A 1 245 LEU 245 467 467 LEU LEU A . n 
A 1 246 PRO 246 468 468 PRO PRO A . n 
A 1 247 GLN 247 469 469 GLN GLN A . n 
A 1 248 GLU 248 470 470 GLU GLU A . n 
A 1 249 MET 249 471 471 MET MET A . n 
A 1 250 VAL 250 472 472 VAL VAL A . n 
A 1 251 THR 251 473 473 THR THR A . n 
A 1 252 HIS 252 474 474 HIS HIS A . n 
A 1 253 PHE 253 475 475 PHE PHE A . n 
A 1 254 TYR 254 476 476 TYR TYR A . n 
A 1 255 GLU 255 477 477 GLU GLU A . n 
A 1 256 GLN 256 478 478 GLN GLN A . n 
A 1 257 GLN 257 479 479 GLN GLN A . n 
A 1 258 ALA 258 480 480 ALA ALA A . n 
A 1 259 PRO 259 481 481 PRO PRO A . n 
A 1 260 SER 260 482 482 SER SER A . n 
A 1 261 GLN 261 483 483 GLN GLN A . n 
A 1 262 GLY 262 484 484 GLY GLY A . n 
A 1 263 ASP 263 485 485 ASP ASP A . n 
A 1 264 VAL 264 486 486 VAL VAL A . n 
A 1 265 ALA 265 487 487 ALA ALA A . n 
A 1 266 LEU 266 488 488 LEU LEU A . n 
A 1 267 VAL 267 489 489 VAL VAL A . n 
A 1 268 ARG 268 490 490 ARG ARG A . n 
A 1 269 TYR 269 491 491 TYR TYR A . n 
A 1 270 ILE 270 492 492 ILE ILE A . n 
A 1 271 ASN 271 493 493 ASN ASN A . n 
A 1 272 ALA 272 494 494 ALA ALA A . n 
A 1 273 GLU 273 495 495 GLU GLU A . n 
A 1 274 THR 274 496 496 THR THR A . n 
A 1 275 GLY 275 497 497 GLY GLY A . n 
A 1 276 ARG 276 498 498 ARG ARG A . n 
A 1 277 VAL 277 499 499 VAL VAL A . n 
A 1 278 MET 278 500 500 MET MET A . n 
A 1 279 PHE 279 501 501 PHE PHE A . n 
A 1 280 GLU 280 502 502 GLU GLU A . n 
A 1 281 GLY 281 503 503 GLY GLY A . n 
A 1 282 LYS 282 504 504 LYS LYS A . n 
A 1 283 LEU 283 505 505 LEU LEU A . n 
A 1 284 HIS 284 506 506 HIS HIS A . n 
A 1 285 ARG 285 507 507 ARG ARG A . n 
A 1 286 ASN 286 508 508 ASN ASN A . n 
A 1 287 GLY 287 509 509 GLY GLY A . n 
A 1 288 PHE 288 510 510 PHE PHE A . n 
A 1 289 PHE 289 511 511 PHE PHE A . n 
A 1 290 THR 290 512 512 THR THR A . n 
A 1 291 VAL 291 513 513 VAL VAL A . n 
A 1 292 SER 292 514 514 SER SER A . n 
A 1 293 ALA 293 515 515 ALA ALA A . n 
A 1 294 THR 294 516 516 THR THR A . n 
A 1 295 ALA 295 517 517 ALA ALA A . n 
A 1 296 ARG 296 518 518 ARG ARG A . n 
A 1 297 THR 297 519 519 THR THR A . n 
A 1 298 LEU 298 520 520 LEU LEU A . n 
A 1 299 ILE 299 521 521 ILE ILE A . n 
A 1 300 VAL 300 522 522 VAL VAL A . n 
A 1 301 PRO 301 523 523 PRO PRO A . n 
A 1 302 ASP 302 524 524 ASP ASP A . n 
A 1 303 GLY 303 525 525 GLY GLY A . n 
A 1 304 TYR 304 526 526 TYR TYR A . n 
A 1 305 PHE 305 527 527 PHE PHE A . n 
A 1 306 ARG 306 528 528 ARG ARG A . n 
A 1 307 PHE 307 529 529 PHE PHE A . n 
A 1 308 ASP 308 530 530 ASP ASP A . n 
A 1 309 SER 309 531 531 SER SER A . n 
A 1 310 TRP 310 532 532 TRP TRP A . n 
A 1 311 VAL 311 533 533 VAL VAL A . n 
A 1 312 ASN 312 534 534 ASN ASN A . n 
A 1 313 ARG 313 535 535 ARG ARG A . n 
A 1 314 PHE 314 536 536 PHE PHE A . n 
A 1 315 TYR 315 537 537 TYR TYR A . n 
A 1 316 THR 316 538 538 THR THR A . n 
A 1 317 LEU 317 539 539 LEU LEU A . n 
A 1 318 SER 318 540 540 SER SER A . n 
A 1 319 PRO 319 541 541 PRO PRO A . n 
A 1 320 MET 320 542 542 MET MET A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CL  1   601  1   CL  CL  A . 
C 3 HOH 1   701  571 HOH HOH A . 
C 3 HOH 2   702  371 HOH HOH A . 
C 3 HOH 3   703  894 HOH HOH A . 
C 3 HOH 4   704  675 HOH HOH A . 
C 3 HOH 5   705  714 HOH HOH A . 
C 3 HOH 6   706  857 HOH HOH A . 
C 3 HOH 7   707  779 HOH HOH A . 
C 3 HOH 8   708  20  HOH HOH A . 
C 3 HOH 9   709  475 HOH HOH A . 
C 3 HOH 10  710  295 HOH HOH A . 
C 3 HOH 11  711  511 HOH HOH A . 
C 3 HOH 12  712  659 HOH HOH A . 
C 3 HOH 13  713  153 HOH HOH A . 
C 3 HOH 14  714  610 HOH HOH A . 
C 3 HOH 15  715  601 HOH HOH A . 
C 3 HOH 16  716  505 HOH HOH A . 
C 3 HOH 17  717  358 HOH HOH A . 
C 3 HOH 18  718  282 HOH HOH A . 
C 3 HOH 19  719  67  HOH HOH A . 
C 3 HOH 20  720  512 HOH HOH A . 
C 3 HOH 21  721  841 HOH HOH A . 
C 3 HOH 22  722  896 HOH HOH A . 
C 3 HOH 23  723  112 HOH HOH A . 
C 3 HOH 24  724  485 HOH HOH A . 
C 3 HOH 25  725  389 HOH HOH A . 
C 3 HOH 26  726  8   HOH HOH A . 
C 3 HOH 27  727  340 HOH HOH A . 
C 3 HOH 28  728  463 HOH HOH A . 
C 3 HOH 29  729  849 HOH HOH A . 
C 3 HOH 30  730  643 HOH HOH A . 
C 3 HOH 31  731  58  HOH HOH A . 
C 3 HOH 32  732  756 HOH HOH A . 
C 3 HOH 33  733  426 HOH HOH A . 
C 3 HOH 34  734  321 HOH HOH A . 
C 3 HOH 35  735  856 HOH HOH A . 
C 3 HOH 36  736  487 HOH HOH A . 
C 3 HOH 37  737  585 HOH HOH A . 
C 3 HOH 38  738  667 HOH HOH A . 
C 3 HOH 39  739  327 HOH HOH A . 
C 3 HOH 40  740  35  HOH HOH A . 
C 3 HOH 41  741  210 HOH HOH A . 
C 3 HOH 42  742  129 HOH HOH A . 
C 3 HOH 43  743  121 HOH HOH A . 
C 3 HOH 44  744  457 HOH HOH A . 
C 3 HOH 45  745  305 HOH HOH A . 
C 3 HOH 46  746  186 HOH HOH A . 
C 3 HOH 47  747  719 HOH HOH A . 
C 3 HOH 48  748  285 HOH HOH A . 
C 3 HOH 49  749  307 HOH HOH A . 
C 3 HOH 50  750  143 HOH HOH A . 
C 3 HOH 51  751  694 HOH HOH A . 
C 3 HOH 52  752  89  HOH HOH A . 
C 3 HOH 53  753  604 HOH HOH A . 
C 3 HOH 54  754  211 HOH HOH A . 
C 3 HOH 55  755  233 HOH HOH A . 
C 3 HOH 56  756  230 HOH HOH A . 
C 3 HOH 57  757  346 HOH HOH A . 
C 3 HOH 58  758  28  HOH HOH A . 
C 3 HOH 59  759  860 HOH HOH A . 
C 3 HOH 60  760  762 HOH HOH A . 
C 3 HOH 61  761  76  HOH HOH A . 
C 3 HOH 62  762  806 HOH HOH A . 
C 3 HOH 63  763  793 HOH HOH A . 
C 3 HOH 64  764  237 HOH HOH A . 
C 3 HOH 65  765  177 HOH HOH A . 
C 3 HOH 66  766  685 HOH HOH A . 
C 3 HOH 67  767  53  HOH HOH A . 
C 3 HOH 68  768  869 HOH HOH A . 
C 3 HOH 69  769  488 HOH HOH A . 
C 3 HOH 70  770  54  HOH HOH A . 
C 3 HOH 71  771  376 HOH HOH A . 
C 3 HOH 72  772  253 HOH HOH A . 
C 3 HOH 73  773  34  HOH HOH A . 
C 3 HOH 74  774  183 HOH HOH A . 
C 3 HOH 75  775  722 HOH HOH A . 
C 3 HOH 76  776  408 HOH HOH A . 
C 3 HOH 77  777  709 HOH HOH A . 
C 3 HOH 78  778  172 HOH HOH A . 
C 3 HOH 79  779  98  HOH HOH A . 
C 3 HOH 80  780  670 HOH HOH A . 
C 3 HOH 81  781  208 HOH HOH A . 
C 3 HOH 82  782  288 HOH HOH A . 
C 3 HOH 83  783  614 HOH HOH A . 
C 3 HOH 84  784  575 HOH HOH A . 
C 3 HOH 85  785  40  HOH HOH A . 
C 3 HOH 86  786  209 HOH HOH A . 
C 3 HOH 87  787  260 HOH HOH A . 
C 3 HOH 88  788  30  HOH HOH A . 
C 3 HOH 89  789  56  HOH HOH A . 
C 3 HOH 90  790  730 HOH HOH A . 
C 3 HOH 91  791  462 HOH HOH A . 
C 3 HOH 92  792  180 HOH HOH A . 
C 3 HOH 93  793  267 HOH HOH A . 
C 3 HOH 94  794  49  HOH HOH A . 
C 3 HOH 95  795  149 HOH HOH A . 
C 3 HOH 96  796  21  HOH HOH A . 
C 3 HOH 97  797  279 HOH HOH A . 
C 3 HOH 98  798  5   HOH HOH A . 
C 3 HOH 99  799  60  HOH HOH A . 
C 3 HOH 100 800  32  HOH HOH A . 
C 3 HOH 101 801  65  HOH HOH A . 
C 3 HOH 102 802  444 HOH HOH A . 
C 3 HOH 103 803  390 HOH HOH A . 
C 3 HOH 104 804  243 HOH HOH A . 
C 3 HOH 105 805  342 HOH HOH A . 
C 3 HOH 106 806  133 HOH HOH A . 
C 3 HOH 107 807  384 HOH HOH A . 
C 3 HOH 108 808  2   HOH HOH A . 
C 3 HOH 109 809  284 HOH HOH A . 
C 3 HOH 110 810  23  HOH HOH A . 
C 3 HOH 111 811  138 HOH HOH A . 
C 3 HOH 112 812  41  HOH HOH A . 
C 3 HOH 113 813  359 HOH HOH A . 
C 3 HOH 114 814  39  HOH HOH A . 
C 3 HOH 115 815  11  HOH HOH A . 
C 3 HOH 116 816  900 HOH HOH A . 
C 3 HOH 117 817  191 HOH HOH A . 
C 3 HOH 118 818  105 HOH HOH A . 
C 3 HOH 119 819  370 HOH HOH A . 
C 3 HOH 120 820  372 HOH HOH A . 
C 3 HOH 121 821  778 HOH HOH A . 
C 3 HOH 122 822  162 HOH HOH A . 
C 3 HOH 123 823  18  HOH HOH A . 
C 3 HOH 124 824  164 HOH HOH A . 
C 3 HOH 125 825  106 HOH HOH A . 
C 3 HOH 126 826  203 HOH HOH A . 
C 3 HOH 127 827  25  HOH HOH A . 
C 3 HOH 128 828  31  HOH HOH A . 
C 3 HOH 129 829  51  HOH HOH A . 
C 3 HOH 130 830  263 HOH HOH A . 
C 3 HOH 131 831  24  HOH HOH A . 
C 3 HOH 132 832  424 HOH HOH A . 
C 3 HOH 133 833  184 HOH HOH A . 
C 3 HOH 134 834  43  HOH HOH A . 
C 3 HOH 135 835  636 HOH HOH A . 
C 3 HOH 136 836  27  HOH HOH A . 
C 3 HOH 137 837  3   HOH HOH A . 
C 3 HOH 138 838  10  HOH HOH A . 
C 3 HOH 139 839  38  HOH HOH A . 
C 3 HOH 140 840  16  HOH HOH A . 
C 3 HOH 141 841  192 HOH HOH A . 
C 3 HOH 142 842  82  HOH HOH A . 
C 3 HOH 143 843  753 HOH HOH A . 
C 3 HOH 144 844  494 HOH HOH A . 
C 3 HOH 145 845  135 HOH HOH A . 
C 3 HOH 146 846  99  HOH HOH A . 
C 3 HOH 147 847  145 HOH HOH A . 
C 3 HOH 148 848  132 HOH HOH A . 
C 3 HOH 149 849  103 HOH HOH A . 
C 3 HOH 150 850  151 HOH HOH A . 
C 3 HOH 151 851  144 HOH HOH A . 
C 3 HOH 152 852  77  HOH HOH A . 
C 3 HOH 153 853  73  HOH HOH A . 
C 3 HOH 154 854  63  HOH HOH A . 
C 3 HOH 155 855  252 HOH HOH A . 
C 3 HOH 156 856  64  HOH HOH A . 
C 3 HOH 157 857  215 HOH HOH A . 
C 3 HOH 158 858  118 HOH HOH A . 
C 3 HOH 159 859  431 HOH HOH A . 
C 3 HOH 160 860  86  HOH HOH A . 
C 3 HOH 161 861  115 HOH HOH A . 
C 3 HOH 162 862  117 HOH HOH A . 
C 3 HOH 163 863  702 HOH HOH A . 
C 3 HOH 164 864  6   HOH HOH A . 
C 3 HOH 165 865  641 HOH HOH A . 
C 3 HOH 166 866  899 HOH HOH A . 
C 3 HOH 167 867  381 HOH HOH A . 
C 3 HOH 168 868  318 HOH HOH A . 
C 3 HOH 169 869  29  HOH HOH A . 
C 3 HOH 170 870  570 HOH HOH A . 
C 3 HOH 171 871  171 HOH HOH A . 
C 3 HOH 172 872  93  HOH HOH A . 
C 3 HOH 173 873  287 HOH HOH A . 
C 3 HOH 174 874  674 HOH HOH A . 
C 3 HOH 175 875  319 HOH HOH A . 
C 3 HOH 176 876  50  HOH HOH A . 
C 3 HOH 177 877  74  HOH HOH A . 
C 3 HOH 178 878  15  HOH HOH A . 
C 3 HOH 179 879  36  HOH HOH A . 
C 3 HOH 180 880  262 HOH HOH A . 
C 3 HOH 181 881  178 HOH HOH A . 
C 3 HOH 182 882  259 HOH HOH A . 
C 3 HOH 183 883  61  HOH HOH A . 
C 3 HOH 184 884  161 HOH HOH A . 
C 3 HOH 185 885  255 HOH HOH A . 
C 3 HOH 186 886  47  HOH HOH A . 
C 3 HOH 187 887  534 HOH HOH A . 
C 3 HOH 188 888  26  HOH HOH A . 
C 3 HOH 189 889  7   HOH HOH A . 
C 3 HOH 190 890  373 HOH HOH A . 
C 3 HOH 191 891  88  HOH HOH A . 
C 3 HOH 192 892  96  HOH HOH A . 
C 3 HOH 193 893  688 HOH HOH A . 
C 3 HOH 194 894  889 HOH HOH A . 
C 3 HOH 195 895  711 HOH HOH A . 
C 3 HOH 196 896  214 HOH HOH A . 
C 3 HOH 197 897  888 HOH HOH A . 
C 3 HOH 198 898  580 HOH HOH A . 
C 3 HOH 199 899  595 HOH HOH A . 
C 3 HOH 200 900  467 HOH HOH A . 
C 3 HOH 201 901  250 HOH HOH A . 
C 3 HOH 202 902  9   HOH HOH A . 
C 3 HOH 203 903  612 HOH HOH A . 
C 3 HOH 204 904  79  HOH HOH A . 
C 3 HOH 205 905  85  HOH HOH A . 
C 3 HOH 206 906  169 HOH HOH A . 
C 3 HOH 207 907  268 HOH HOH A . 
C 3 HOH 208 908  706 HOH HOH A . 
C 3 HOH 209 909  68  HOH HOH A . 
C 3 HOH 210 910  514 HOH HOH A . 
C 3 HOH 211 911  201 HOH HOH A . 
C 3 HOH 212 912  116 HOH HOH A . 
C 3 HOH 213 913  66  HOH HOH A . 
C 3 HOH 214 914  299 HOH HOH A . 
C 3 HOH 215 915  156 HOH HOH A . 
C 3 HOH 216 916  216 HOH HOH A . 
C 3 HOH 217 917  712 HOH HOH A . 
C 3 HOH 218 918  101 HOH HOH A . 
C 3 HOH 219 919  159 HOH HOH A . 
C 3 HOH 220 920  37  HOH HOH A . 
C 3 HOH 221 921  22  HOH HOH A . 
C 3 HOH 222 922  57  HOH HOH A . 
C 3 HOH 223 923  459 HOH HOH A . 
C 3 HOH 224 924  14  HOH HOH A . 
C 3 HOH 225 925  114 HOH HOH A . 
C 3 HOH 226 926  264 HOH HOH A . 
C 3 HOH 227 927  842 HOH HOH A . 
C 3 HOH 228 928  111 HOH HOH A . 
C 3 HOH 229 929  154 HOH HOH A . 
C 3 HOH 230 930  759 HOH HOH A . 
C 3 HOH 231 931  91  HOH HOH A . 
C 3 HOH 232 932  421 HOH HOH A . 
C 3 HOH 233 933  590 HOH HOH A . 
C 3 HOH 234 934  339 HOH HOH A . 
C 3 HOH 235 935  553 HOH HOH A . 
C 3 HOH 236 936  306 HOH HOH A . 
C 3 HOH 237 937  412 HOH HOH A . 
C 3 HOH 238 938  656 HOH HOH A . 
C 3 HOH 239 939  42  HOH HOH A . 
C 3 HOH 240 940  187 HOH HOH A . 
C 3 HOH 241 941  309 HOH HOH A . 
C 3 HOH 242 942  715 HOH HOH A . 
C 3 HOH 243 943  573 HOH HOH A . 
C 3 HOH 244 944  173 HOH HOH A . 
C 3 HOH 245 945  170 HOH HOH A . 
C 3 HOH 246 946  436 HOH HOH A . 
C 3 HOH 247 947  256 HOH HOH A . 
C 3 HOH 248 948  236 HOH HOH A . 
C 3 HOH 249 949  628 HOH HOH A . 
C 3 HOH 250 950  84  HOH HOH A . 
C 3 HOH 251 951  598 HOH HOH A . 
C 3 HOH 252 952  95  HOH HOH A . 
C 3 HOH 253 953  231 HOH HOH A . 
C 3 HOH 254 954  131 HOH HOH A . 
C 3 HOH 255 955  261 HOH HOH A . 
C 3 HOH 256 956  325 HOH HOH A . 
C 3 HOH 257 957  298 HOH HOH A . 
C 3 HOH 258 958  420 HOH HOH A . 
C 3 HOH 259 959  152 HOH HOH A . 
C 3 HOH 260 960  46  HOH HOH A . 
C 3 HOH 261 961  228 HOH HOH A . 
C 3 HOH 262 962  80  HOH HOH A . 
C 3 HOH 263 963  1   HOH HOH A . 
C 3 HOH 264 964  668 HOH HOH A . 
C 3 HOH 265 965  168 HOH HOH A . 
C 3 HOH 266 966  380 HOH HOH A . 
C 3 HOH 267 967  528 HOH HOH A . 
C 3 HOH 268 968  400 HOH HOH A . 
C 3 HOH 269 969  407 HOH HOH A . 
C 3 HOH 270 970  126 HOH HOH A . 
C 3 HOH 271 971  218 HOH HOH A . 
C 3 HOH 272 972  52  HOH HOH A . 
C 3 HOH 273 973  148 HOH HOH A . 
C 3 HOH 274 974  48  HOH HOH A . 
C 3 HOH 275 975  301 HOH HOH A . 
C 3 HOH 276 976  97  HOH HOH A . 
C 3 HOH 277 977  113 HOH HOH A . 
C 3 HOH 278 978  157 HOH HOH A . 
C 3 HOH 279 979  181 HOH HOH A . 
C 3 HOH 280 980  836 HOH HOH A . 
C 3 HOH 281 981  92  HOH HOH A . 
C 3 HOH 282 982  4   HOH HOH A . 
C 3 HOH 283 983  619 HOH HOH A . 
C 3 HOH 284 984  535 HOH HOH A . 
C 3 HOH 285 985  276 HOH HOH A . 
C 3 HOH 286 986  219 HOH HOH A . 
C 3 HOH 287 987  624 HOH HOH A . 
C 3 HOH 288 988  242 HOH HOH A . 
C 3 HOH 289 989  136 HOH HOH A . 
C 3 HOH 290 990  649 HOH HOH A . 
C 3 HOH 291 991  526 HOH HOH A . 
C 3 HOH 292 992  395 HOH HOH A . 
C 3 HOH 293 993  865 HOH HOH A . 
C 3 HOH 294 994  137 HOH HOH A . 
C 3 HOH 295 995  606 HOH HOH A . 
C 3 HOH 296 996  165 HOH HOH A . 
C 3 HOH 297 997  286 HOH HOH A . 
C 3 HOH 298 998  102 HOH HOH A . 
C 3 HOH 299 999  193 HOH HOH A . 
C 3 HOH 300 1000 128 HOH HOH A . 
C 3 HOH 301 1001 75  HOH HOH A . 
C 3 HOH 302 1002 596 HOH HOH A . 
C 3 HOH 303 1003 150 HOH HOH A . 
C 3 HOH 304 1004 225 HOH HOH A . 
C 3 HOH 305 1005 100 HOH HOH A . 
C 3 HOH 306 1006 175 HOH HOH A . 
C 3 HOH 307 1007 204 HOH HOH A . 
C 3 HOH 308 1008 484 HOH HOH A . 
C 3 HOH 309 1009 59  HOH HOH A . 
C 3 HOH 310 1010 679 HOH HOH A . 
C 3 HOH 311 1011 87  HOH HOH A . 
C 3 HOH 312 1012 62  HOH HOH A . 
C 3 HOH 313 1013 769 HOH HOH A . 
C 3 HOH 314 1014 654 HOH HOH A . 
C 3 HOH 315 1015 337 HOH HOH A . 
C 3 HOH 316 1016 155 HOH HOH A . 
C 3 HOH 317 1017 623 HOH HOH A . 
C 3 HOH 318 1018 546 HOH HOH A . 
C 3 HOH 319 1019 107 HOH HOH A . 
C 3 HOH 320 1020 479 HOH HOH A . 
C 3 HOH 321 1021 78  HOH HOH A . 
C 3 HOH 322 1022 323 HOH HOH A . 
C 3 HOH 323 1023 238 HOH HOH A . 
C 3 HOH 324 1024 130 HOH HOH A . 
C 3 HOH 325 1025 206 HOH HOH A . 
C 3 HOH 326 1026 274 HOH HOH A . 
C 3 HOH 327 1027 351 HOH HOH A . 
C 3 HOH 328 1028 499 HOH HOH A . 
C 3 HOH 329 1029 583 HOH HOH A . 
C 3 HOH 330 1030 817 HOH HOH A . 
C 3 HOH 331 1031 502 HOH HOH A . 
C 3 HOH 332 1032 69  HOH HOH A . 
C 3 HOH 333 1033 584 HOH HOH A . 
C 3 HOH 334 1034 690 HOH HOH A . 
C 3 HOH 335 1035 767 HOH HOH A . 
C 3 HOH 336 1036 492 HOH HOH A . 
C 3 HOH 337 1037 369 HOH HOH A . 
C 3 HOH 338 1038 343 HOH HOH A . 
C 3 HOH 339 1039 451 HOH HOH A . 
C 3 HOH 340 1040 44  HOH HOH A . 
C 3 HOH 341 1041 320 HOH HOH A . 
C 3 HOH 342 1042 119 HOH HOH A . 
C 3 HOH 343 1043 357 HOH HOH A . 
C 3 HOH 344 1044 227 HOH HOH A . 
C 3 HOH 345 1045 142 HOH HOH A . 
C 3 HOH 346 1046 507 HOH HOH A . 
C 3 HOH 347 1047 55  HOH HOH A . 
C 3 HOH 348 1048 618 HOH HOH A . 
C 3 HOH 349 1049 386 HOH HOH A . 
C 3 HOH 350 1050 565 HOH HOH A . 
C 3 HOH 351 1051 560 HOH HOH A . 
C 3 HOH 352 1052 185 HOH HOH A . 
C 3 HOH 353 1053 548 HOH HOH A . 
C 3 HOH 354 1054 648 HOH HOH A . 
C 3 HOH 355 1055 202 HOH HOH A . 
C 3 HOH 356 1056 705 HOH HOH A . 
C 3 HOH 357 1057 754 HOH HOH A . 
C 3 HOH 358 1058 17  HOH HOH A . 
C 3 HOH 359 1059 897 HOH HOH A . 
C 3 HOH 360 1060 360 HOH HOH A . 
C 3 HOH 361 1061 578 HOH HOH A . 
C 3 HOH 362 1062 188 HOH HOH A . 
C 3 HOH 363 1063 622 HOH HOH A . 
C 3 HOH 364 1064 627 HOH HOH A . 
C 3 HOH 365 1065 666 HOH HOH A . 
C 3 HOH 366 1066 403 HOH HOH A . 
C 3 HOH 367 1067 356 HOH HOH A . 
C 3 HOH 368 1068 642 HOH HOH A . 
C 3 HOH 369 1069 350 HOH HOH A . 
C 3 HOH 370 1070 450 HOH HOH A . 
C 3 HOH 371 1071 671 HOH HOH A . 
C 3 HOH 372 1072 698 HOH HOH A . 
C 3 HOH 373 1073 401 HOH HOH A . 
C 3 HOH 374 1074 786 HOH HOH A . 
C 3 HOH 375 1075 827 HOH HOH A . 
C 3 HOH 376 1076 764 HOH HOH A . 
C 3 HOH 377 1077 752 HOH HOH A . 
C 3 HOH 378 1078 576 HOH HOH A . 
C 3 HOH 379 1079 72  HOH HOH A . 
C 3 HOH 380 1080 332 HOH HOH A . 
C 3 HOH 381 1081 611 HOH HOH A . 
C 3 HOH 382 1082 399 HOH HOH A . 
C 3 HOH 383 1083 713 HOH HOH A . 
C 3 HOH 384 1084 385 HOH HOH A . 
C 3 HOH 385 1085 822 HOH HOH A . 
C 3 HOH 386 1086 608 HOH HOH A . 
C 3 HOH 387 1087 844 HOH HOH A . 
C 3 HOH 388 1088 701 HOH HOH A . 
C 3 HOH 389 1089 874 HOH HOH A . 
C 3 HOH 390 1090 410 HOH HOH A . 
C 3 HOH 391 1091 655 HOH HOH A . 
C 3 HOH 392 1092 527 HOH HOH A . 
C 3 HOH 393 1093 316 HOH HOH A . 
C 3 HOH 394 1094 140 HOH HOH A . 
C 3 HOH 395 1095 845 HOH HOH A . 
C 3 HOH 396 1096 746 HOH HOH A . 
C 3 HOH 397 1097 687 HOH HOH A . 
C 3 HOH 398 1098 651 HOH HOH A . 
C 3 HOH 399 1099 826 HOH HOH A . 
C 3 HOH 400 1100 680 HOH HOH A . 
C 3 HOH 401 1101 12  HOH HOH A . 
C 3 HOH 402 1102 417 HOH HOH A . 
C 3 HOH 403 1103 404 HOH HOH A . 
C 3 HOH 404 1104 468 HOH HOH A . 
C 3 HOH 405 1105 717 HOH HOH A . 
C 3 HOH 406 1106 870 HOH HOH A . 
C 3 HOH 407 1107 94  HOH HOH A . 
C 3 HOH 408 1108 828 HOH HOH A . 
C 3 HOH 409 1109 615 HOH HOH A . 
C 3 HOH 410 1110 804 HOH HOH A . 
C 3 HOH 411 1111 609 HOH HOH A . 
C 3 HOH 412 1112 269 HOH HOH A . 
C 3 HOH 413 1113 387 HOH HOH A . 
C 3 HOH 414 1114 729 HOH HOH A . 
C 3 HOH 415 1115 525 HOH HOH A . 
C 3 HOH 416 1116 398 HOH HOH A . 
C 3 HOH 417 1117 362 HOH HOH A . 
C 3 HOH 418 1118 447 HOH HOH A . 
C 3 HOH 419 1119 644 HOH HOH A . 
C 3 HOH 420 1120 483 HOH HOH A . 
C 3 HOH 421 1121 271 HOH HOH A . 
C 3 HOH 422 1122 529 HOH HOH A . 
C 3 HOH 423 1123 265 HOH HOH A . 
C 3 HOH 424 1124 338 HOH HOH A . 
C 3 HOH 425 1125 891 HOH HOH A . 
C 3 HOH 426 1126 650 HOH HOH A . 
C 3 HOH 427 1127 658 HOH HOH A . 
C 3 HOH 428 1128 782 HOH HOH A . 
C 3 HOH 429 1129 220 HOH HOH A . 
C 3 HOH 430 1130 549 HOH HOH A . 
C 3 HOH 431 1131 454 HOH HOH A . 
C 3 HOH 432 1132 176 HOH HOH A . 
C 3 HOH 433 1133 653 HOH HOH A . 
C 3 HOH 434 1134 315 HOH HOH A . 
C 3 HOH 435 1135 294 HOH HOH A . 
C 3 HOH 436 1136 347 HOH HOH A . 
C 3 HOH 437 1137 591 HOH HOH A . 
C 3 HOH 438 1138 158 HOH HOH A . 
C 3 HOH 439 1139 602 HOH HOH A . 
C 3 HOH 440 1140 829 HOH HOH A . 
C 3 HOH 441 1141 710 HOH HOH A . 
C 3 HOH 442 1142 632 HOH HOH A . 
C 3 HOH 443 1143 257 HOH HOH A . 
C 3 HOH 444 1144 160 HOH HOH A . 
C 3 HOH 445 1145 354 HOH HOH A . 
C 3 HOH 446 1146 200 HOH HOH A . 
C 3 HOH 447 1147 348 HOH HOH A . 
C 3 HOH 448 1148 895 HOH HOH A . 
C 3 HOH 449 1149 862 HOH HOH A . 
C 3 HOH 450 1150 328 HOH HOH A . 
C 3 HOH 451 1151 699 HOH HOH A . 
C 3 HOH 452 1152 365 HOH HOH A . 
C 3 HOH 453 1153 213 HOH HOH A . 
C 3 HOH 454 1154 207 HOH HOH A . 
C 3 HOH 455 1155 597 HOH HOH A . 
C 3 HOH 456 1156 423 HOH HOH A . 
C 3 HOH 457 1157 559 HOH HOH A . 
C 3 HOH 458 1158 293 HOH HOH A . 
C 3 HOH 459 1159 875 HOH HOH A . 
C 3 HOH 460 1160 189 HOH HOH A . 
C 3 HOH 461 1161 518 HOH HOH A . 
C 3 HOH 462 1162 334 HOH HOH A . 
C 3 HOH 463 1163 557 HOH HOH A . 
C 3 HOH 464 1164 581 HOH HOH A . 
C 3 HOH 465 1165 725 HOH HOH A . 
C 3 HOH 466 1166 473 HOH HOH A . 
C 3 HOH 467 1167 835 HOH HOH A . 
C 3 HOH 468 1168 281 HOH HOH A . 
C 3 HOH 469 1169 123 HOH HOH A . 
C 3 HOH 470 1170 278 HOH HOH A . 
C 3 HOH 471 1171 727 HOH HOH A . 
C 3 HOH 472 1172 522 HOH HOH A . 
C 3 HOH 473 1173 592 HOH HOH A . 
C 3 HOH 474 1174 251 HOH HOH A . 
C 3 HOH 475 1175 458 HOH HOH A . 
C 3 HOH 476 1176 336 HOH HOH A . 
C 3 HOH 477 1177 290 HOH HOH A . 
C 3 HOH 478 1178 901 HOH HOH A . 
C 3 HOH 479 1179 733 HOH HOH A . 
C 3 HOH 480 1180 805 HOH HOH A . 
C 3 HOH 481 1181 245 HOH HOH A . 
C 3 HOH 482 1182 449 HOH HOH A . 
C 3 HOH 483 1183 898 HOH HOH A . 
C 3 HOH 484 1184 634 HOH HOH A . 
C 3 HOH 485 1185 493 HOH HOH A . 
C 3 HOH 486 1186 550 HOH HOH A . 
C 3 HOH 487 1187 810 HOH HOH A . 
C 3 HOH 488 1188 495 HOH HOH A . 
C 3 HOH 489 1189 240 HOH HOH A . 
C 3 HOH 490 1190 196 HOH HOH A . 
C 3 HOH 491 1191 291 HOH HOH A . 
C 3 HOH 492 1192 229 HOH HOH A . 
C 3 HOH 493 1193 720 HOH HOH A . 
C 3 HOH 494 1194 811 HOH HOH A . 
C 3 HOH 495 1195 480 HOH HOH A . 
C 3 HOH 496 1196 249 HOH HOH A . 
C 3 HOH 497 1197 737 HOH HOH A . 
C 3 HOH 498 1198 751 HOH HOH A . 
C 3 HOH 499 1199 139 HOH HOH A . 
C 3 HOH 500 1200 433 HOH HOH A . 
C 3 HOH 501 1201 416 HOH HOH A . 
C 3 HOH 502 1202 682 HOH HOH A . 
C 3 HOH 503 1203 304 HOH HOH A . 
C 3 HOH 504 1204 543 HOH HOH A . 
C 3 HOH 505 1205 540 HOH HOH A . 
C 3 HOH 506 1206 639 HOH HOH A . 
C 3 HOH 507 1207 326 HOH HOH A . 
C 3 HOH 508 1208 657 HOH HOH A . 
C 3 HOH 509 1209 466 HOH HOH A . 
C 3 HOH 510 1210 310 HOH HOH A . 
C 3 HOH 511 1211 272 HOH HOH A . 
C 3 HOH 512 1212 813 HOH HOH A . 
C 3 HOH 513 1213 780 HOH HOH A . 
C 3 HOH 514 1214 890 HOH HOH A . 
C 3 HOH 515 1215 530 HOH HOH A . 
C 3 HOH 516 1216 743 HOH HOH A . 
C 3 HOH 517 1217 345 HOH HOH A . 
C 3 HOH 518 1218 413 HOH HOH A . 
C 3 HOH 519 1219 542 HOH HOH A . 
C 3 HOH 520 1220 81  HOH HOH A . 
C 3 HOH 521 1221 392 HOH HOH A . 
C 3 HOH 522 1222 452 HOH HOH A . 
C 3 HOH 523 1223 765 HOH HOH A . 
C 3 HOH 524 1224 574 HOH HOH A . 
C 3 HOH 525 1225 768 HOH HOH A . 
C 3 HOH 526 1226 863 HOH HOH A . 
C 3 HOH 527 1227 539 HOH HOH A . 
C 3 HOH 528 1228 569 HOH HOH A . 
C 3 HOH 529 1229 90  HOH HOH A . 
C 3 HOH 530 1230 317 HOH HOH A . 
C 3 HOH 531 1231 790 HOH HOH A . 
C 3 HOH 532 1232 71  HOH HOH A . 
C 3 HOH 533 1233 691 HOH HOH A . 
C 3 HOH 534 1234 195 HOH HOH A . 
C 3 HOH 535 1235 672 HOH HOH A . 
C 3 HOH 536 1236 174 HOH HOH A . 
C 3 HOH 537 1237 558 HOH HOH A . 
C 3 HOH 538 1238 603 HOH HOH A . 
C 3 HOH 539 1239 441 HOH HOH A . 
C 3 HOH 540 1240 567 HOH HOH A . 
C 3 HOH 541 1241 361 HOH HOH A . 
C 3 HOH 542 1242 104 HOH HOH A . 
C 3 HOH 543 1243 892 HOH HOH A . 
C 3 HOH 544 1244 322 HOH HOH A . 
C 3 HOH 545 1245 212 HOH HOH A . 
C 3 HOH 546 1246 545 HOH HOH A . 
C 3 HOH 547 1247 886 HOH HOH A . 
C 3 HOH 548 1248 564 HOH HOH A . 
C 3 HOH 549 1249 788 HOH HOH A . 
C 3 HOH 550 1250 270 HOH HOH A . 
C 3 HOH 551 1251 732 HOH HOH A . 
C 3 HOH 552 1252 124 HOH HOH A . 
C 3 HOH 553 1253 221 HOH HOH A . 
C 3 HOH 554 1254 640 HOH HOH A . 
C 3 HOH 555 1255 205 HOH HOH A . 
C 3 HOH 556 1256 633 HOH HOH A . 
C 3 HOH 557 1257 555 HOH HOH A . 
C 3 HOH 558 1258 330 HOH HOH A . 
C 3 HOH 559 1259 652 HOH HOH A . 
C 3 HOH 560 1260 904 HOH HOH A . 
C 3 HOH 561 1261 556 HOH HOH A . 
C 3 HOH 562 1262 599 HOH HOH A . 
C 3 HOH 563 1263 579 HOH HOH A . 
C 3 HOH 564 1264 464 HOH HOH A . 
C 3 HOH 565 1265 803 HOH HOH A . 
C 3 HOH 566 1266 825 HOH HOH A . 
C 3 HOH 567 1267 223 HOH HOH A . 
C 3 HOH 568 1268 777 HOH HOH A . 
C 3 HOH 569 1269 108 HOH HOH A . 
C 3 HOH 570 1270 877 HOH HOH A . 
C 3 HOH 571 1271 626 HOH HOH A . 
C 3 HOH 572 1272 663 HOH HOH A . 
C 3 HOH 573 1273 224 HOH HOH A . 
C 3 HOH 574 1274 364 HOH HOH A . 
C 3 HOH 575 1275 647 HOH HOH A . 
C 3 HOH 576 1276 887 HOH HOH A . 
C 3 HOH 577 1277 605 HOH HOH A . 
C 3 HOH 578 1278 846 HOH HOH A . 
C 3 HOH 579 1279 110 HOH HOH A . 
C 3 HOH 580 1280 600 HOH HOH A . 
C 3 HOH 581 1281 289 HOH HOH A . 
C 3 HOH 582 1282 314 HOH HOH A . 
C 3 HOH 583 1283 783 HOH HOH A . 
C 3 HOH 584 1284 134 HOH HOH A . 
C 3 HOH 585 1285 616 HOH HOH A . 
C 3 HOH 586 1286 577 HOH HOH A . 
C 3 HOH 587 1287 198 HOH HOH A . 
C 3 HOH 588 1288 572 HOH HOH A . 
C 3 HOH 589 1289 785 HOH HOH A . 
C 3 HOH 590 1290 741 HOH HOH A . 
C 3 HOH 591 1291 620 HOH HOH A . 
C 3 HOH 592 1292 311 HOH HOH A . 
C 3 HOH 593 1293 563 HOH HOH A . 
C 3 HOH 594 1294 638 HOH HOH A . 
C 3 HOH 595 1295 787 HOH HOH A . 
C 3 HOH 596 1296 277 HOH HOH A . 
C 3 HOH 597 1297 402 HOH HOH A . 
C 3 HOH 598 1298 396 HOH HOH A . 
C 3 HOH 599 1299 83  HOH HOH A . 
C 3 HOH 600 1300 194 HOH HOH A . 
C 3 HOH 601 1301 378 HOH HOH A . 
C 3 HOH 602 1302 222 HOH HOH A . 
C 3 HOH 603 1303 544 HOH HOH A . 
C 3 HOH 604 1304 446 HOH HOH A . 
C 3 HOH 605 1305 693 HOH HOH A . 
C 3 HOH 606 1306 532 HOH HOH A . 
C 3 HOH 607 1307 773 HOH HOH A . 
C 3 HOH 608 1308 903 HOH HOH A . 
C 3 HOH 609 1309 353 HOH HOH A . 
C 3 HOH 610 1310 33  HOH HOH A . 
C 3 HOH 611 1311 331 HOH HOH A . 
C 3 HOH 612 1312 735 HOH HOH A . 
C 3 HOH 613 1313 300 HOH HOH A . 
C 3 HOH 614 1314 235 HOH HOH A . 
C 3 HOH 615 1315 179 HOH HOH A . 
C 3 HOH 616 1316 394 HOH HOH A . 
C 3 HOH 617 1317 254 HOH HOH A . 
C 3 HOH 618 1318 607 HOH HOH A . 
C 3 HOH 619 1319 589 HOH HOH A . 
C 3 HOH 620 1320 629 HOH HOH A . 
C 3 HOH 621 1321 329 HOH HOH A . 
C 3 HOH 622 1322 437 HOH HOH A . 
C 3 HOH 623 1323 341 HOH HOH A . 
C 3 HOH 624 1324 796 HOH HOH A . 
C 3 HOH 625 1325 868 HOH HOH A . 
C 3 HOH 626 1326 524 HOH HOH A . 
C 3 HOH 627 1327 147 HOH HOH A . 
C 3 HOH 628 1328 503 HOH HOH A . 
C 3 HOH 629 1329 197 HOH HOH A . 
C 3 HOH 630 1330 440 HOH HOH A . 
C 3 HOH 631 1331 613 HOH HOH A . 
C 3 HOH 632 1332 541 HOH HOH A . 
C 3 HOH 633 1333 167 HOH HOH A . 
C 3 HOH 634 1334 684 HOH HOH A . 
C 3 HOH 635 1335 141 HOH HOH A . 
C 3 HOH 636 1336 453 HOH HOH A . 
C 3 HOH 637 1337 368 HOH HOH A . 
C 3 HOH 638 1338 677 HOH HOH A . 
C 3 HOH 639 1339 239 HOH HOH A . 
C 3 HOH 640 1340 109 HOH HOH A . 
C 3 HOH 641 1341 859 HOH HOH A . 
C 3 HOH 642 1342 241 HOH HOH A . 
C 3 HOH 643 1343 275 HOH HOH A . 
C 3 HOH 644 1344 531 HOH HOH A . 
C 3 HOH 645 1345 594 HOH HOH A . 
C 3 HOH 646 1346 248 HOH HOH A . 
C 3 HOH 647 1347 434 HOH HOH A . 
C 3 HOH 648 1348 190 HOH HOH A . 
C 3 HOH 649 1349 736 HOH HOH A . 
C 3 HOH 650 1350 442 HOH HOH A . 
C 3 HOH 651 1351 474 HOH HOH A . 
C 3 HOH 652 1352 537 HOH HOH A . 
C 3 HOH 653 1353 366 HOH HOH A . 
C 3 HOH 654 1354 593 HOH HOH A . 
C 3 HOH 655 1355 521 HOH HOH A . 
C 3 HOH 656 1356 724 HOH HOH A . 
C 3 HOH 657 1357 755 HOH HOH A . 
C 3 HOH 658 1358 430 HOH HOH A . 
C 3 HOH 659 1359 678 HOH HOH A . 
C 3 HOH 660 1360 831 HOH HOH A . 
C 3 HOH 661 1361 683 HOH HOH A . 
C 3 HOH 662 1362 864 HOH HOH A . 
C 3 HOH 663 1363 646 HOH HOH A . 
C 3 HOH 664 1364 878 HOH HOH A . 
C 3 HOH 665 1365 438 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? 0.7.8       2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .           3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? 9.0.002     4 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? .           5 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EDP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     107.241 
_cell.length_a_esd                 ? 
_cell.length_b                     107.241 
_cell.length_b_esd                 ? 
_cell.length_c                     61.577 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EDP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EDP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.88 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.31 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Bis-Tris (pH 5.5), 25% w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-12-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.95372 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.95372 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX1 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EDP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.76 
_reflns.d_resolution_low                               46.44 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40834 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.57 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.108 
_reflns.pdbx_Rpim_I_all                                0.029 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       563727 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.104 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.76 
_reflns_shell.d_res_low                                     1.79 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           31242 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2291 
_reflns_shell.percent_possible_obs                          99.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.6 
_reflns_shell.pdbx_chi_squared                              0.53 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.2 
_reflns_shell.pdbx_Rrim_I_all                               1.030 
_reflns_shell.pdbx_Rpim_I_all                               0.273 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.843 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.992 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EDP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.76 
_refine.ls_d_res_low                             46.44 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     40809 
_refine.ls_number_reflns_R_free                  1998 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.89 
_refine.ls_percent_reflns_R_free                 4.90 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1415 
_refine.ls_R_factor_R_free                       0.1807 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1395 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.44 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.17 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.76 
_refine_hist.d_res_low                        46.44 
_refine_hist.number_atoms_solvent             665 
_refine_hist.number_atoms_total               3060 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2394 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006  ? 2682 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.821  ? 3697 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 11.832 ? 1037 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.058  ? 399  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007  ? 500  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.76 1.80  . . 139 2694 99.00  . . . . 0.2201 . . . . . . . . . . . 0.2591 
'X-RAY DIFFRACTION' 1.80 1.85  . . 142 2758 100.00 . . . . 0.1873 . . . . . . . . . . . 0.2549 
'X-RAY DIFFRACTION' 1.85 1.90  . . 143 2752 100.00 . . . . 0.1725 . . . . . . . . . . . 0.2166 
'X-RAY DIFFRACTION' 1.91 1.97  . . 144 2727 100.00 . . . . 0.1579 . . . . . . . . . . . 0.1937 
'X-RAY DIFFRACTION' 1.97 2.04  . . 142 2769 100.00 . . . . 0.1636 . . . . . . . . . . . 0.2095 
'X-RAY DIFFRACTION' 2.04 2.12  . . 141 2749 100.00 . . . . 0.1464 . . . . . . . . . . . 0.1791 
'X-RAY DIFFRACTION' 2.12 2.21  . . 144 2749 100.00 . . . . 0.1459 . . . . . . . . . . . 0.1892 
'X-RAY DIFFRACTION' 2.21 2.33  . . 144 2788 100.00 . . . . 0.1416 . . . . . . . . . . . 0.1989 
'X-RAY DIFFRACTION' 2.33 2.48  . . 140 2775 100.00 . . . . 0.1487 . . . . . . . . . . . 0.1954 
'X-RAY DIFFRACTION' 2.48 2.67  . . 140 2757 100.00 . . . . 0.1428 . . . . . . . . . . . 0.1778 
'X-RAY DIFFRACTION' 2.67 2.94  . . 147 2782 100.00 . . . . 0.1490 . . . . . . . . . . . 0.1755 
'X-RAY DIFFRACTION' 2.94 3.36  . . 140 2790 100.00 . . . . 0.1241 . . . . . . . . . . . 0.1788 
'X-RAY DIFFRACTION' 3.36 4.24  . . 147 2817 100.00 . . . . 0.1127 . . . . . . . . . . . 0.1462 
'X-RAY DIFFRACTION' 4.24 46.44 . . 145 2904 100.00 . . . . 0.1258 . . . . . . . . . . . 0.1642 
# 
_struct.entry_id                     9EDP 
_struct.title                        'GVIII-Chiba040502 norovirus protruding domain' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EDP 
_struct_keywords.text            'norovirus, P domain, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q3V574_9CALI 
_struct_ref.pdbx_db_accession          Q3V574 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;TPFTLPRLPISEMTNSRFPLVIKGMVVDPNLPLQANFQNGRITLDGELQGTTLPTSTSIGRISGTYMSSTPSRIIQHEDS
GDSTQPRVFNPVWMDLTENNWTEFQPFNDQPAPLGCPDFKAKILGTLIRQPNNGSYYFDAYLDTRQHGTFAPYTGHAAVH
SDQQAGHLAQGYKIQFSPTGIESDQNTDLNQLPDYGGAMTVSKGLAPAAAPDFPGEMILYFVSDMPVRNPNGERRDTEIL
CLLPQEMVTHFYEQQAPSQGDVALVRYINAETGRVMFEGKLHRNGFFTVSATARTLIVPDGYFRFDSWVNRFYTLSPM
;
_struct_ref.pdbx_align_begin           225 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EDP 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 320 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q3V574 
_struct_ref_seq.db_align_beg                  225 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       225 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EDP GLY A 1 ? UNP Q3V574 ? ? 'expression tag' 223 1 
1 9EDP SER A 2 ? UNP Q3V574 ? ? 'expression tag' 224 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3520  ? 
1 MORE         -37   ? 
1 'SSA (A^2)'  24520 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z  1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 4_555 y,x,-z -0.5000000000 0.8660254038 0.0000000000 0.0000000000 0.8660254038 0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PRO A 11  ? MET A 15  ? PRO A 233 MET A 237 5 ? 5  
HELX_P HELX_P2 AA2 PRO A 133 ? GLY A 136 ? PRO A 355 GLY A 358 5 ? 4  
HELX_P HELX_P3 AA3 PRO A 154 ? THR A 156 ? PRO A 376 THR A 378 5 ? 3  
HELX_P HELX_P4 AA4 ASN A 231 ? GLU A 235 ? ASN A 453 GLU A 457 5 ? 5  
HELX_P HELX_P5 AA5 PRO A 246 ? GLN A 257 ? PRO A 468 GLN A 479 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? anti-parallel 
AA3 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 239 ? CYS A 243 ? THR A 461 CYS A 465 
AA1 2 GLU A 218 ? MET A 227 ? GLU A 440 MET A 449 
AA1 3 GLY A 26  ? VAL A 29  ? GLY A 248 VAL A 251 
AA1 4 THR A 297 ? ILE A 299 ? THR A 519 ILE A 521 
AA2 1 THR A 239 ? CYS A 243 ? THR A 461 CYS A 465 
AA2 2 GLU A 218 ? MET A 227 ? GLU A 440 MET A 449 
AA2 3 PHE A 288 ? SER A 292 ? PHE A 510 SER A 514 
AA2 4 VAL A 277 ? HIS A 284 ? VAL A 499 HIS A 506 
AA2 5 VAL A 264 ? ASN A 271 ? VAL A 486 ASN A 493 
AA2 6 GLY A 303 ? VAL A 311 ? GLY A 525 VAL A 533 
AA3 1 PHE A 152 ? ALA A 153 ? PHE A 374 ALA A 375 
AA3 2 HIS A 158 ? SER A 163 ? HIS A 380 SER A 385 
AA3 3 TYR A 138 ? ASP A 145 ? TYR A 360 ASP A 367 
AA3 4 LYS A 124 ? ARG A 131 ? LYS A 346 ARG A 353 
AA3 5 LYS A 175 ? ILE A 183 ? LYS A 397 ILE A 405 
AA3 6 ILE A 64  ? MET A 69  ? ILE A 286 MET A 291 
AA3 7 ASN A 92  ? THR A 99  ? ASN A 314 THR A 321 
AA3 8 HIS A 158 ? SER A 163 ? HIS A 380 SER A 385 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O CYS A 243 ? O CYS A 465 N PHE A 223 ? N PHE A 445 
AA1 2 3 O TYR A 222 ? O TYR A 444 N VAL A 28  ? N VAL A 250 
AA1 3 4 N MET A 27  ? N MET A 249 O ILE A 299 ? O ILE A 521 
AA2 1 2 O CYS A 243 ? O CYS A 465 N PHE A 223 ? N PHE A 445 
AA2 2 3 N LEU A 221 ? N LEU A 443 O PHE A 289 ? O PHE A 511 
AA2 3 4 O PHE A 288 ? O PHE A 510 N HIS A 284 ? N HIS A 506 
AA2 4 5 O MET A 278 ? O MET A 500 N TYR A 269 ? N TYR A 491 
AA2 5 6 N LEU A 266 ? N LEU A 488 O SER A 309 ? O SER A 531 
AA3 1 2 N ALA A 153 ? N ALA A 375 O HIS A 158 ? O HIS A 380 
AA3 2 3 O HIS A 162 ? O HIS A 384 N TYR A 143 ? N TYR A 365 
AA3 3 4 O PHE A 140 ? O PHE A 362 N LEU A 129 ? N LEU A 351 
AA3 4 5 N LEU A 126 ? N LEU A 348 O THR A 181 ? O THR A 403 
AA3 5 6 O PHE A 178 ? O PHE A 400 N ILE A 64  ? N ILE A 286 
AA3 6 7 N THR A 67  ? N THR A 289 O ASP A 97  ? O ASP A 319 
AA3 7 8 N VAL A 94  ? N VAL A 316 O VAL A 161 ? O VAL A 383 
# 
_pdbx_entry_details.entry_id                   9EDP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 282 ? ? -158.20 36.54   
2 1 ASN A 332 ? ? -115.65 -132.67 
3 1 VAL A 425 ? A -65.13  81.17   
4 1 SER A 426 ? B -132.71 -32.88  
5 1 ARG A 459 ? ? -152.04 84.98   
6 1 ASP A 524 ? ? -92.71  49.66   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 702  ? C HOH . 
2 1 A HOH 812  ? C HOH . 
3 1 A HOH 957  ? C HOH . 
4 1 A HOH 1059 ? C HOH . 
5 1 A HOH 1298 ? C HOH . 
6 1 A HOH 1306 ? C HOH . 
7 1 A HOH 1310 ? C HOH . 
8 1 A HOH 1344 ? C HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1358 ? 5.81 . 
2 1 O ? A HOH 1359 ? 5.96 . 
3 1 O ? A HOH 1360 ? 6.16 . 
4 1 O ? A HOH 1361 ? 6.26 . 
5 1 O ? A HOH 1362 ? 6.80 . 
6 1 O ? A HOH 1363 ? 6.84 . 
7 1 O ? A HOH 1364 ? 6.86 . 
8 1 O ? A HOH 1365 ? 6.99 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 296 ? A SER 74 
2  1 Y 1 A ARG 297 ? A ARG 75 
3  1 Y 1 A ILE 298 ? A ILE 76 
4  1 Y 1 A ILE 299 ? A ILE 77 
5  1 Y 1 A GLN 300 ? A GLN 78 
6  1 Y 1 A HIS 301 ? A HIS 79 
7  1 Y 1 A GLU 302 ? A GLU 80 
8  1 Y 1 A ASP 303 ? A ASP 81 
9  1 Y 1 A SER 304 ? A SER 82 
10 1 Y 1 A GLY 305 ? A GLY 83 
11 1 Y 1 A ASP 306 ? A ASP 84 
12 1 Y 1 A SER 307 ? A SER 85 
13 1 Y 1 A THR 308 ? A THR 86 
14 1 Y 1 A GLN 309 ? A GLN 87 
15 1 Y 1 A PRO 310 ? A PRO 88 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
THR N    N  N N 305 
THR CA   C  N S 306 
THR C    C  N N 307 
THR O    O  N N 308 
THR CB   C  N R 309 
THR OG1  O  N N 310 
THR CG2  C  N N 311 
THR OXT  O  N N 312 
THR H    H  N N 313 
THR H2   H  N N 314 
THR HA   H  N N 315 
THR HB   H  N N 316 
THR HG1  H  N N 317 
THR HG21 H  N N 318 
THR HG22 H  N N 319 
THR HG23 H  N N 320 
THR HXT  H  N N 321 
TRP N    N  N N 322 
TRP CA   C  N S 323 
TRP C    C  N N 324 
TRP O    O  N N 325 
TRP CB   C  N N 326 
TRP CG   C  Y N 327 
TRP CD1  C  Y N 328 
TRP CD2  C  Y N 329 
TRP NE1  N  Y N 330 
TRP CE2  C  Y N 331 
TRP CE3  C  Y N 332 
TRP CZ2  C  Y N 333 
TRP CZ3  C  Y N 334 
TRP CH2  C  Y N 335 
TRP OXT  O  N N 336 
TRP H    H  N N 337 
TRP H2   H  N N 338 
TRP HA   H  N N 339 
TRP HB2  H  N N 340 
TRP HB3  H  N N 341 
TRP HD1  H  N N 342 
TRP HE1  H  N N 343 
TRP HE3  H  N N 344 
TRP HZ2  H  N N 345 
TRP HZ3  H  N N 346 
TRP HH2  H  N N 347 
TRP HXT  H  N N 348 
TYR N    N  N N 349 
TYR CA   C  N S 350 
TYR C    C  N N 351 
TYR O    O  N N 352 
TYR CB   C  N N 353 
TYR CG   C  Y N 354 
TYR CD1  C  Y N 355 
TYR CD2  C  Y N 356 
TYR CE1  C  Y N 357 
TYR CE2  C  Y N 358 
TYR CZ   C  Y N 359 
TYR OH   O  N N 360 
TYR OXT  O  N N 361 
TYR H    H  N N 362 
TYR H2   H  N N 363 
TYR HA   H  N N 364 
TYR HB2  H  N N 365 
TYR HB3  H  N N 366 
TYR HD1  H  N N 367 
TYR HD2  H  N N 368 
TYR HE1  H  N N 369 
TYR HE2  H  N N 370 
TYR HH   H  N N 371 
TYR HXT  H  N N 372 
VAL N    N  N N 373 
VAL CA   C  N S 374 
VAL C    C  N N 375 
VAL O    O  N N 376 
VAL CB   C  N N 377 
VAL CG1  C  N N 378 
VAL CG2  C  N N 379 
VAL OXT  O  N N 380 
VAL H    H  N N 381 
VAL H2   H  N N 382 
VAL HA   H  N N 383 
VAL HB   H  N N 384 
VAL HG11 H  N N 385 
VAL HG12 H  N N 386 
VAL HG13 H  N N 387 
VAL HG21 H  N N 388 
VAL HG22 H  N N 389 
VAL HG23 H  N N 390 
VAL HXT  H  N N 391 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5F4M 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EDP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009325 
_atom_sites.fract_transf_matrix[1][2]   0.005384 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010767 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016240 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY A 1 1   ? -36.905 -67.350 8.544   1.00 58.37 ? 223  GLY A N   1 
ATOM   2    C  CA  . GLY A 1 1   ? -37.557 -66.076 8.781   1.00 59.16 ? 223  GLY A CA  1 
ATOM   3    C  C   . GLY A 1 1   ? -36.607 -64.899 8.923   1.00 50.81 ? 223  GLY A C   1 
ATOM   4    O  O   . GLY A 1 1   ? -36.993 -63.754 8.684   1.00 58.06 ? 223  GLY A O   1 
ATOM   5    N  N   . SER A 1 2   ? -35.361 -65.168 9.310   1.00 48.21 ? 224  SER A N   1 
ATOM   6    C  CA  . SER A 1 2   ? -34.401 -64.093 9.526   1.00 48.07 ? 224  SER A CA  1 
ATOM   7    C  C   . SER A 1 2   ? -33.847 -63.590 8.196   1.00 38.29 ? 224  SER A C   1 
ATOM   8    O  O   . SER A 1 2   ? -33.661 -64.359 7.249   1.00 35.03 ? 224  SER A O   1 
ATOM   9    C  CB  . SER A 1 2   ? -33.266 -64.553 10.444  1.00 39.97 ? 224  SER A CB  1 
ATOM   10   O  OG  . SER A 1 2   ? -32.441 -65.521 9.818   1.00 57.66 ? 224  SER A OG  1 
ATOM   11   N  N   . THR A 1 3   ? -33.604 -62.289 8.130   1.00 34.01 ? 225  THR A N   1 
ATOM   12   C  CA  . THR A 1 3   ? -33.106 -61.653 6.918   1.00 27.46 ? 225  THR A CA  1 
ATOM   13   C  C   . THR A 1 3   ? -31.761 -62.245 6.513   1.00 22.50 ? 225  THR A C   1 
ATOM   14   O  O   . THR A 1 3   ? -30.822 -62.237 7.328   1.00 27.30 ? 225  THR A O   1 
ATOM   15   C  CB  . THR A 1 3   ? -32.961 -60.152 7.150   1.00 29.62 ? 225  THR A CB  1 
ATOM   16   O  OG1 . THR A 1 3   ? -34.242 -59.592 7.460   1.00 32.39 ? 225  THR A OG1 1 
ATOM   17   C  CG2 . THR A 1 3   ? -32.383 -59.473 5.919   1.00 30.06 ? 225  THR A CG2 1 
ATOM   18   N  N   . PRO A 1 4   ? -31.620 -62.772 5.299   1.00 24.63 ? 226  PRO A N   1 
ATOM   19   C  CA  . PRO A 1 4   ? -30.318 -63.301 4.882   1.00 25.95 ? 226  PRO A CA  1 
ATOM   20   C  C   . PRO A 1 4   ? -29.297 -62.185 4.775   1.00 22.89 ? 226  PRO A C   1 
ATOM   21   O  O   . PRO A 1 4   ? -29.611 -61.072 4.353   1.00 20.31 ? 226  PRO A O   1 
ATOM   22   C  CB  . PRO A 1 4   ? -30.604 -63.928 3.510   1.00 26.87 ? 226  PRO A CB  1 
ATOM   23   C  CG  . PRO A 1 4   ? -32.090 -64.123 3.472   1.00 32.28 ? 226  PRO A CG  1 
ATOM   24   C  CD  . PRO A 1 4   ? -32.666 -63.010 4.290   1.00 26.24 ? 226  PRO A CD  1 
ATOM   25   N  N   . PHE A 1 5   ? -28.065 -62.496 5.154   1.00 21.21 ? 227  PHE A N   1 
ATOM   26   C  CA  . PHE A 1 5   ? -26.989 -61.528 5.012   1.00 20.87 ? 227  PHE A CA  1 
ATOM   27   C  C   . PHE A 1 5   ? -26.621 -61.367 3.545   1.00 17.92 ? 227  PHE A C   1 
ATOM   28   O  O   . PHE A 1 5   ? -26.479 -62.355 2.816   1.00 17.22 ? 227  PHE A O   1 
ATOM   29   C  CB  . PHE A 1 5   ? -25.763 -61.966 5.812   1.00 20.40 ? 227  PHE A CB  1 
ATOM   30   C  CG  . PHE A 1 5   ? -24.614 -61.011 5.702   1.00 15.52 ? 227  PHE A CG  1 
ATOM   31   C  CD1 . PHE A 1 5   ? -24.698 -59.745 6.267   1.00 15.71 ? 227  PHE A CD1 1 
ATOM   32   C  CD2 . PHE A 1 5   ? -23.464 -61.364 5.015   1.00 15.54 ? 227  PHE A CD2 1 
ATOM   33   C  CE1 . PHE A 1 5   ? -23.642 -58.856 6.161   1.00 15.18 ? 227  PHE A CE1 1 
ATOM   34   C  CE2 . PHE A 1 5   ? -22.410 -60.474 4.909   1.00 14.83 ? 227  PHE A CE2 1 
ATOM   35   C  CZ  . PHE A 1 5   ? -22.499 -59.225 5.486   1.00 14.62 ? 227  PHE A CZ  1 
ATOM   36   N  N   . THR A 1 6   ? -26.468 -60.117 3.109   1.00 17.46 ? 228  THR A N   1 
ATOM   37   C  CA  . THR A 1 6   ? -26.061 -59.814 1.745   1.00 15.61 ? 228  THR A CA  1 
ATOM   38   C  C   . THR A 1 6   ? -25.120 -58.618 1.753   1.00 14.28 ? 228  THR A C   1 
ATOM   39   O  O   . THR A 1 6   ? -25.061 -57.851 2.717   1.00 16.06 ? 228  THR A O   1 
ATOM   40   C  CB  . THR A 1 6   ? -27.254 -59.475 0.822   1.00 19.66 ? 228  THR A CB  1 
ATOM   41   O  OG1 . THR A 1 6   ? -27.871 -58.254 1.259   1.00 18.26 ? 228  THR A OG1 1 
ATOM   42   C  CG2 . THR A 1 6   ? -28.299 -60.603 0.792   1.00 20.17 ? 228  THR A CG2 1 
ATOM   43   N  N   . LEU A 1 7   ? -24.366 -58.485 0.656   1.00 15.56 ? 229  LEU A N   1 
ATOM   44   C  CA  A LEU A 1 7   ? -23.579 -57.318 0.314   0.55 15.58 ? 229  LEU A CA  1 
ATOM   45   C  CA  B LEU A 1 7   ? -23.562 -57.328 0.293   0.45 15.59 ? 229  LEU A CA  1 
ATOM   46   C  C   . LEU A 1 7   ? -24.308 -56.502 -0.745  1.00 15.91 ? 229  LEU A C   1 
ATOM   47   O  O   . LEU A 1 7   ? -25.106 -57.046 -1.510  1.00 15.26 ? 229  LEU A O   1 
ATOM   48   C  CB  A LEU A 1 7   ? -22.205 -57.731 -0.215  0.55 15.00 ? 229  LEU A CB  1 
ATOM   49   C  CB  B LEU A 1 7   ? -22.205 -57.747 -0.289  0.45 14.97 ? 229  LEU A CB  1 
ATOM   50   C  CG  A LEU A 1 7   ? -21.339 -58.346 0.885   0.55 22.37 ? 229  LEU A CG  1 
ATOM   51   C  CG  B LEU A 1 7   ? -21.015 -58.090 0.623   0.45 21.44 ? 229  LEU A CG  1 
ATOM   52   C  CD1 A LEU A 1 7   ? -20.215 -59.183 0.310   0.55 14.88 ? 229  LEU A CD1 1 
ATOM   53   C  CD1 B LEU A 1 7   ? -20.150 -56.867 0.899   0.45 18.06 ? 229  LEU A CD1 1 
ATOM   54   C  CD2 A LEU A 1 7   ? -20.803 -57.224 1.751   0.55 18.42 ? 229  LEU A CD2 1 
ATOM   55   C  CD2 B LEU A 1 7   ? -21.482 -58.712 1.928   0.45 15.22 ? 229  LEU A CD2 1 
ATOM   56   N  N   . PRO A 1 8   ? -24.090 -55.191 -0.808  1.00 13.18 ? 230  PRO A N   1 
ATOM   57   C  CA  . PRO A 1 8   ? -24.732 -54.408 -1.873  1.00 15.17 ? 230  PRO A CA  1 
ATOM   58   C  C   . PRO A 1 8   ? -24.159 -54.813 -3.223  1.00 17.16 ? 230  PRO A C   1 
ATOM   59   O  O   . PRO A 1 8   ? -22.944 -54.938 -3.381  1.00 19.27 ? 230  PRO A O   1 
ATOM   60   C  CB  . PRO A 1 8   ? -24.381 -52.958 -1.517  1.00 18.24 ? 230  PRO A CB  1 
ATOM   61   C  CG  . PRO A 1 8   ? -23.148 -53.049 -0.691  1.00 20.18 ? 230  PRO A CG  1 
ATOM   62   C  CD  . PRO A 1 8   ? -23.209 -54.366 0.042   1.00 14.85 ? 230  PRO A CD  1 
ATOM   63   N  N   . ARG A 1 9   ? -25.038 -55.038 -4.205  1.00 16.50 ? 231  ARG A N   1 
ATOM   64   C  CA  A ARG A 1 9   ? -24.586 -55.435 -5.538  0.42 17.95 ? 231  ARG A CA  1 
ATOM   65   C  CA  B ARG A 1 9   ? -24.580 -55.436 -5.536  0.58 17.87 ? 231  ARG A CA  1 
ATOM   66   C  C   . ARG A 1 9   ? -24.207 -54.176 -6.316  1.00 22.08 ? 231  ARG A C   1 
ATOM   67   O  O   . ARG A 1 9   ? -24.914 -53.705 -7.208  1.00 19.25 ? 231  ARG A O   1 
ATOM   68   C  CB  A ARG A 1 9   ? -25.650 -56.251 -6.260  0.42 25.99 ? 231  ARG A CB  1 
ATOM   69   C  CB  B ARG A 1 9   ? -25.633 -56.271 -6.252  0.58 26.00 ? 231  ARG A CB  1 
ATOM   70   C  CG  A ARG A 1 9   ? -25.170 -56.811 -7.596  0.42 30.47 ? 231  ARG A CG  1 
ATOM   71   C  CG  B ARG A 1 9   ? -25.026 -57.378 -7.110  0.58 32.33 ? 231  ARG A CG  1 
ATOM   72   C  CD  A ARG A 1 9   ? -26.144 -57.821 -8.182  0.42 37.69 ? 231  ARG A CD  1 
ATOM   73   C  CD  B ARG A 1 9   ? -25.893 -58.632 -7.100  0.58 48.49 ? 231  ARG A CD  1 
ATOM   74   N  NE  A ARG A 1 9   ? -25.754 -58.222 -9.529  0.42 41.95 ? 231  ARG A NE  1 
ATOM   75   N  NE  B ARG A 1 9   ? -25.143 -59.828 -7.470  0.58 47.52 ? 231  ARG A NE  1 
ATOM   76   C  CZ  A ARG A 1 9   ? -24.878 -59.179 -9.802  0.42 39.28 ? 231  ARG A CZ  1 
ATOM   77   C  CZ  B ARG A 1 9   ? -24.530 -60.624 -6.604  0.58 40.92 ? 231  ARG A CZ  1 
ATOM   78   N  NH1 A ARG A 1 9   ? -24.279 -59.863 -8.841  0.42 41.33 ? 231  ARG A NH1 1 
ATOM   79   N  NH1 B ARG A 1 9   ? -24.553 -60.379 -5.304  0.58 28.54 ? 231  ARG A NH1 1 
ATOM   80   N  NH2 A ARG A 1 9   ? -24.596 -59.457 -11.072 0.42 40.35 ? 231  ARG A NH2 1 
ATOM   81   N  NH2 B ARG A 1 9   ? -23.879 -61.694 -7.053  0.58 42.94 ? 231  ARG A NH2 1 
ATOM   82   N  N   . LEU A 1 10  ? -23.061 -53.615 -5.938  1.00 16.64 ? 232  LEU A N   1 
ATOM   83   C  CA  . LEU A 1 10  ? -22.514 -52.425 -6.554  1.00 15.70 ? 232  LEU A CA  1 
ATOM   84   C  C   . LEU A 1 10  ? -21.022 -52.652 -6.711  1.00 14.51 ? 232  LEU A C   1 
ATOM   85   O  O   . LEU A 1 10  ? -20.389 -53.190 -5.792  1.00 14.95 ? 232  LEU A O   1 
ATOM   86   C  CB  . LEU A 1 10  ? -22.732 -51.180 -5.688  1.00 14.03 ? 232  LEU A CB  1 
ATOM   87   C  CG  . LEU A 1 10  ? -24.156 -50.797 -5.320  1.00 20.03 ? 232  LEU A CG  1 
ATOM   88   C  CD1 . LEU A 1 10  ? -24.112 -49.689 -4.272  1.00 22.48 ? 232  LEU A CD1 1 
ATOM   89   C  CD2 . LEU A 1 10  ? -24.912 -50.363 -6.566  1.00 24.75 ? 232  LEU A CD2 1 
ATOM   90   N  N   . PRO A 1 11  ? -20.424 -52.231 -7.820  1.00 15.98 ? 233  PRO A N   1 
ATOM   91   C  CA  . PRO A 1 11  ? -18.964 -52.303 -7.917  1.00 15.44 ? 233  PRO A CA  1 
ATOM   92   C  C   . PRO A 1 11  ? -18.326 -51.321 -6.951  1.00 13.80 ? 233  PRO A C   1 
ATOM   93   O  O   . PRO A 1 11  ? -18.893 -50.271 -6.633  1.00 13.01 ? 233  PRO A O   1 
ATOM   94   C  CB  . PRO A 1 11  ? -18.674 -51.923 -9.372  1.00 15.23 ? 233  PRO A CB  1 
ATOM   95   C  CG  . PRO A 1 11  ? -19.820 -51.030 -9.744  1.00 16.50 ? 233  PRO A CG  1 
ATOM   96   C  CD  . PRO A 1 11  ? -21.028 -51.556 -8.984  1.00 17.68 ? 233  PRO A CD  1 
ATOM   97   N  N   . ILE A 1 12  ? -17.140 -51.700 -6.458  1.00 11.71 ? 234  ILE A N   1 
ATOM   98   C  CA  . ILE A 1 12  ? -16.429 -50.852 -5.503  1.00 12.90 ? 234  ILE A CA  1 
ATOM   99   C  C   . ILE A 1 12  ? -16.169 -49.474 -6.093  1.00 9.81  ? 234  ILE A C   1 
ATOM   100  O  O   . ILE A 1 12  ? -16.102 -48.477 -5.359  1.00 13.29 ? 234  ILE A O   1 
ATOM   101  C  CB  . ILE A 1 12  ? -15.118 -51.532 -5.064  1.00 15.17 ? 234  ILE A CB  1 
ATOM   102  C  CG1 . ILE A 1 12  ? -15.408 -52.912 -4.471  1.00 15.42 ? 234  ILE A CG1 1 
ATOM   103  C  CG2 . ILE A 1 12  ? -14.379 -50.669 -4.046  1.00 17.11 ? 234  ILE A CG2 1 
ATOM   104  C  CD1 . ILE A 1 12  ? -16.344 -52.868 -3.291  1.00 19.05 ? 234  ILE A CD1 1 
ATOM   105  N  N   . SER A 1 13  ? -16.016 -49.393 -7.421  1.00 12.39 ? 235  SER A N   1 
ATOM   106  C  CA  . SER A 1 13  ? -15.759 -48.124 -8.084  1.00 14.14 ? 235  SER A CA  1 
ATOM   107  C  C   . SER A 1 13  ? -16.893 -47.123 -7.888  1.00 15.26 ? 235  SER A C   1 
ATOM   108  O  O   . SER A 1 13  ? -16.680 -45.922 -8.085  1.00 15.12 ? 235  SER A O   1 
ATOM   109  C  CB  . SER A 1 13  ? -15.546 -48.355 -9.588  1.00 12.83 ? 235  SER A CB  1 
ATOM   110  O  OG  . SER A 1 13  ? -16.716 -48.921 -10.167 1.00 15.94 ? 235  SER A OG  1 
ATOM   111  N  N   . GLU A 1 14  ? -18.091 -47.584 -7.530  1.00 12.56 ? 236  GLU A N   1 
ATOM   112  C  CA  . GLU A 1 14  ? -19.226 -46.695 -7.314  1.00 12.50 ? 236  GLU A CA  1 
ATOM   113  C  C   . GLU A 1 14  ? -19.453 -46.394 -5.837  1.00 15.80 ? 236  GLU A C   1 
ATOM   114  O  O   . GLU A 1 14  ? -20.450 -45.756 -5.481  1.00 14.51 ? 236  GLU A O   1 
ATOM   115  C  CB  . GLU A 1 14  ? -20.481 -47.291 -7.955  1.00 15.10 ? 236  GLU A CB  1 
ATOM   116  C  CG  . GLU A 1 14  ? -20.358 -47.258 -9.482  1.00 13.88 ? 236  GLU A CG  1 
ATOM   117  C  CD  . GLU A 1 14  ? -21.480 -47.956 -10.232 1.00 20.93 ? 236  GLU A CD  1 
ATOM   118  O  OE1 . GLU A 1 14  ? -22.386 -48.521 -9.599  1.00 17.45 ? 236  GLU A OE1 1 
ATOM   119  O  OE2 . GLU A 1 14  ? -21.435 -47.939 -11.478 1.00 28.96 ? 236  GLU A OE2 1 
ATOM   120  N  N   . MET A 1 15  ? -18.537 -46.809 -4.977  1.00 12.57 ? 237  MET A N   1 
ATOM   121  C  CA  . MET A 1 15  ? -18.679 -46.582 -3.552  1.00 10.72 ? 237  MET A CA  1 
ATOM   122  C  C   . MET A 1 15  ? -17.809 -45.417 -3.094  1.00 13.51 ? 237  MET A C   1 
ATOM   123  O  O   . MET A 1 15  ? -16.939 -44.927 -3.817  1.00 12.38 ? 237  MET A O   1 
ATOM   124  C  CB  . MET A 1 15  ? -18.324 -47.857 -2.787  1.00 12.31 ? 237  MET A CB  1 
ATOM   125  C  CG  . MET A 1 15  ? -19.248 -48.992 -3.117  1.00 12.44 ? 237  MET A CG  1 
ATOM   126  S  SD  . MET A 1 15  ? -18.957 -50.374 -2.008  1.00 14.32 ? 237  MET A SD  1 
ATOM   127  C  CE  . MET A 1 15  ? -20.195 -51.540 -2.594  1.00 17.21 ? 237  MET A CE  1 
ATOM   128  N  N   . THR A 1 16  ? -18.048 -44.980 -1.858  1.00 11.39 ? 238  THR A N   1 
ATOM   129  C  CA  . THR A 1 16  ? -17.378 -43.811 -1.319  1.00 9.60  ? 238  THR A CA  1 
ATOM   130  C  C   . THR A 1 16  ? -16.767 -44.138 0.036   1.00 12.19 ? 238  THR A C   1 
ATOM   131  O  O   . THR A 1 16  ? -17.189 -45.068 0.724   1.00 11.85 ? 238  THR A O   1 
ATOM   132  C  CB  . THR A 1 16  ? -18.335 -42.621 -1.172  1.00 14.29 ? 238  THR A CB  1 
ATOM   133  O  OG1 . THR A 1 16  ? -19.452 -43.019 -0.371  1.00 14.60 ? 238  THR A OG1 1 
ATOM   134  C  CG2 . THR A 1 16  ? -18.827 -42.174 -2.553  1.00 12.61 ? 238  THR A CG2 1 
ATOM   135  N  N   . ASN A 1 17  ? -15.746 -43.361 0.392   1.00 10.43 ? 239  ASN A N   1 
ATOM   136  C  CA  . ASN A 1 17  ? -15.017 -43.584 1.635   1.00 10.22 ? 239  ASN A CA  1 
ATOM   137  C  C   . ASN A 1 17  ? -15.895 -43.272 2.842   1.00 13.29 ? 239  ASN A C   1 
ATOM   138  O  O   . ASN A 1 17  ? -16.674 -42.312 2.836   1.00 14.82 ? 239  ASN A O   1 
ATOM   139  C  CB  . ASN A 1 17  ? -13.760 -42.705 1.640   1.00 11.54 ? 239  ASN A CB  1 
ATOM   140  C  CG  . ASN A 1 17  ? -12.633 -43.269 2.500   1.00 13.43 ? 239  ASN A CG  1 
ATOM   141  O  OD1 . ASN A 1 17  ? -12.710 -43.243 3.724   1.00 13.44 ? 239  ASN A OD1 1 
ATOM   142  N  ND2 . ASN A 1 17  ? -11.549 -43.725 1.855   1.00 11.99 ? 239  ASN A ND2 1 
ATOM   143  N  N   . SER A 1 18  ? -15.754 -44.075 3.894   1.00 12.01 ? 240  SER A N   1 
ATOM   144  C  CA  . SER A 1 18  ? -16.504 -43.850 5.124   1.00 10.40 ? 240  SER A CA  1 
ATOM   145  C  C   . SER A 1 18  ? -15.824 -42.878 6.089   1.00 12.18 ? 240  SER A C   1 
ATOM   146  O  O   . SER A 1 18  ? -16.402 -42.575 7.141   1.00 13.00 ? 240  SER A O   1 
ATOM   147  C  CB  . SER A 1 18  ? -16.739 -45.188 5.836   1.00 9.77  ? 240  SER A CB  1 
ATOM   148  O  OG  . SER A 1 18  ? -15.517 -45.896 5.985   1.00 13.14 ? 240  SER A OG  1 
ATOM   149  N  N   . ARG A 1 19  ? -14.616 -42.396 5.771   1.00 10.41 ? 241  ARG A N   1 
ATOM   150  C  CA  . ARG A 1 19  ? -13.883 -41.490 6.650   1.00 8.97  ? 241  ARG A CA  1 
ATOM   151  C  C   . ARG A 1 19  ? -13.722 -40.085 6.079   1.00 15.20 ? 241  ARG A C   1 
ATOM   152  O  O   . ARG A 1 19  ? -13.259 -39.187 6.799   1.00 12.65 ? 241  ARG A O   1 
ATOM   153  C  CB  . ARG A 1 19  ? -12.493 -42.079 6.969   1.00 13.74 ? 241  ARG A CB  1 
ATOM   154  C  CG  . ARG A 1 19  ? -12.559 -43.427 7.706   1.00 11.76 ? 241  ARG A CG  1 
ATOM   155  C  CD  . ARG A 1 19  ? -11.161 -44.000 7.970   1.00 12.40 ? 241  ARG A CD  1 
ATOM   156  N  NE  . ARG A 1 19  ? -10.387 -43.121 8.839   1.00 12.84 ? 241  ARG A NE  1 
ATOM   157  C  CZ  . ARG A 1 19  ? -9.090  -42.877 8.702   1.00 14.96 ? 241  ARG A CZ  1 
ATOM   158  N  NH1 . ARG A 1 19  ? -8.374  -43.446 7.740   1.00 13.27 ? 241  ARG A NH1 1 
ATOM   159  N  NH2 . ARG A 1 19  ? -8.500  -42.031 9.545   1.00 14.02 ? 241  ARG A NH2 1 
ATOM   160  N  N   . PHE A 1 20  ? -14.098 -39.868 4.821   1.00 11.77 ? 242  PHE A N   1 
ATOM   161  C  CA  . PHE A 1 20  ? -14.032 -38.556 4.181   1.00 15.76 ? 242  PHE A CA  1 
ATOM   162  C  C   . PHE A 1 20  ? -14.853 -38.646 2.897   1.00 14.50 ? 242  PHE A C   1 
ATOM   163  O  O   . PHE A 1 20  ? -14.932 -39.723 2.293   1.00 13.32 ? 242  PHE A O   1 
ATOM   164  C  CB  . PHE A 1 20  ? -12.578 -38.155 3.901   1.00 12.35 ? 242  PHE A CB  1 
ATOM   165  C  CG  . PHE A 1 20  ? -12.332 -36.656 3.891   1.00 11.55 ? 242  PHE A CG  1 
ATOM   166  C  CD1 . PHE A 1 20  ? -12.276 -35.938 5.083   1.00 12.20 ? 242  PHE A CD1 1 
ATOM   167  C  CD2 . PHE A 1 20  ? -12.126 -35.984 2.697   1.00 14.65 ? 242  PHE A CD2 1 
ATOM   168  C  CE1 . PHE A 1 20  ? -12.033 -34.572 5.077   1.00 17.68 ? 242  PHE A CE1 1 
ATOM   169  C  CE2 . PHE A 1 20  ? -11.890 -34.614 2.684   1.00 17.00 ? 242  PHE A CE2 1 
ATOM   170  C  CZ  . PHE A 1 20  ? -11.841 -33.911 3.891   1.00 17.55 ? 242  PHE A CZ  1 
ATOM   171  N  N   . PRO A 1 21  ? -15.514 -37.561 2.474   1.00 15.17 ? 243  PRO A N   1 
ATOM   172  C  CA  . PRO A 1 21  ? -16.417 -37.648 1.312   1.00 17.52 ? 243  PRO A CA  1 
ATOM   173  C  C   . PRO A 1 21  ? -15.666 -37.777 -0.006  1.00 16.39 ? 243  PRO A C   1 
ATOM   174  O  O   . PRO A 1 21  ? -15.407 -36.778 -0.682  1.00 15.09 ? 243  PRO A O   1 
ATOM   175  C  CB  . PRO A 1 21  ? -17.216 -36.335 1.378   1.00 16.26 ? 243  PRO A CB  1 
ATOM   176  C  CG  . PRO A 1 21  ? -16.404 -35.409 2.235   1.00 20.54 ? 243  PRO A CG  1 
ATOM   177  C  CD  . PRO A 1 21  ? -15.666 -36.298 3.222   1.00 16.54 ? 243  PRO A CD  1 
ATOM   178  N  N   . LEU A 1 22  ? -15.302 -39.008 -0.361  1.00 13.92 ? 244  LEU A N   1 
ATOM   179  C  CA  . LEU A 1 22  ? -14.422 -39.283 -1.496  1.00 11.07 ? 244  LEU A CA  1 
ATOM   180  C  C   . LEU A 1 22  ? -14.824 -40.606 -2.129  1.00 11.95 ? 244  LEU A C   1 
ATOM   181  O  O   . LEU A 1 22  ? -15.321 -41.503 -1.452  1.00 14.80 ? 244  LEU A O   1 
ATOM   182  C  CB  . LEU A 1 22  ? -12.961 -39.381 -1.047  1.00 12.33 ? 244  LEU A CB  1 
ATOM   183  C  CG  . LEU A 1 22  ? -12.369 -38.206 -0.277  1.00 12.68 ? 244  LEU A CG  1 
ATOM   184  C  CD1 . LEU A 1 22  ? -11.044 -38.637 0.345   1.00 13.31 ? 244  LEU A CD1 1 
ATOM   185  C  CD2 . LEU A 1 22  ? -12.177 -37.045 -1.232  1.00 15.04 ? 244  LEU A CD2 1 
ATOM   186  N  N   . VAL A 1 23  ? -14.599 -40.731 -3.440  1.00 12.39 ? 245  VAL A N   1 
ATOM   187  C  CA  . VAL A 1 23  ? -14.839 -42.005 -4.105  1.00 11.34 ? 245  VAL A CA  1 
ATOM   188  C  C   . VAL A 1 23  ? -13.726 -42.990 -3.753  1.00 9.80  ? 245  VAL A C   1 
ATOM   189  O  O   . VAL A 1 23  ? -12.582 -42.612 -3.477  1.00 13.18 ? 245  VAL A O   1 
ATOM   190  C  CB  . VAL A 1 23  ? -14.948 -41.798 -5.629  1.00 11.96 ? 245  VAL A CB  1 
ATOM   191  C  CG1 . VAL A 1 23  ? -13.588 -41.422 -6.210  1.00 18.52 ? 245  VAL A CG1 1 
ATOM   192  C  CG2 . VAL A 1 23  ? -15.517 -43.046 -6.313  1.00 13.14 ? 245  VAL A CG2 1 
ATOM   193  N  N   . ILE A 1 24  ? -14.071 -44.272 -3.757  1.00 12.66 ? 246  ILE A N   1 
ATOM   194  C  CA  . ILE A 1 24  ? -13.081 -45.331 -3.593  1.00 9.56  ? 246  ILE A CA  1 
ATOM   195  C  C   . ILE A 1 24  ? -12.378 -45.524 -4.924  1.00 14.12 ? 246  ILE A C   1 
ATOM   196  O  O   . ILE A 1 24  ? -13.034 -45.695 -5.960  1.00 14.74 ? 246  ILE A O   1 
ATOM   197  C  CB  . ILE A 1 24  ? -13.740 -46.641 -3.143  1.00 11.74 ? 246  ILE A CB  1 
ATOM   198  C  CG1 . ILE A 1 24  ? -14.474 -46.465 -1.801  1.00 12.10 ? 246  ILE A CG1 1 
ATOM   199  C  CG2 . ILE A 1 24  ? -12.676 -47.747 -3.027  1.00 12.12 ? 246  ILE A CG2 1 
ATOM   200  C  CD1 . ILE A 1 24  ? -13.555 -46.091 -0.666  1.00 12.49 ? 246  ILE A CD1 1 
ATOM   201  N  N   . LYS A 1 25  ? -11.048 -45.502 -4.904  1.00 12.10 ? 247  LYS A N   1 
ATOM   202  C  CA  . LYS A 1 25  ? -10.280 -45.709 -6.127  1.00 12.23 ? 247  LYS A CA  1 
ATOM   203  C  C   . LYS A 1 25  ? -9.662  -47.102 -6.224  1.00 15.39 ? 247  LYS A C   1 
ATOM   204  O  O   . LYS A 1 25  ? -9.102  -47.440 -7.275  1.00 14.43 ? 247  LYS A O   1 
ATOM   205  C  CB  . LYS A 1 25  ? -9.178  -44.652 -6.233  1.00 18.77 ? 247  LYS A CB  1 
ATOM   206  C  CG  . LYS A 1 25  ? -8.056  -44.900 -5.262  1.00 19.28 ? 247  LYS A CG  1 
ATOM   207  C  CD  . LYS A 1 25  ? -6.889  -43.958 -5.495  1.00 27.50 ? 247  LYS A CD  1 
ATOM   208  C  CE  . LYS A 1 25  ? -6.374  -44.046 -6.909  1.00 28.34 ? 247  LYS A CE  1 
ATOM   209  N  NZ  . LYS A 1 25  ? -5.347  -43.000 -7.170  1.00 30.80 ? 247  LYS A NZ  1 
ATOM   210  N  N   . GLY A 1 26  ? -9.749  -47.907 -5.176  1.00 13.81 ? 248  GLY A N   1 
ATOM   211  C  CA  . GLY A 1 26  ? -9.238  -49.263 -5.225  1.00 13.47 ? 248  GLY A CA  1 
ATOM   212  C  C   . GLY A 1 26  ? -9.120  -49.838 -3.826  1.00 15.30 ? 248  GLY A C   1 
ATOM   213  O  O   . GLY A 1 26  ? -9.598  -49.261 -2.855  1.00 12.86 ? 248  GLY A O   1 
ATOM   214  N  N   . MET A 1 27  ? -8.487  -51.006 -3.753  1.00 12.72 ? 249  MET A N   1 
ATOM   215  C  CA  . MET A 1 27  ? -8.225  -51.659 -2.476  1.00 11.45 ? 249  MET A CA  1 
ATOM   216  C  C   . MET A 1 27  ? -6.745  -52.003 -2.390  1.00 14.27 ? 249  MET A C   1 
ATOM   217  O  O   . MET A 1 27  ? -6.073  -52.159 -3.407  1.00 12.87 ? 249  MET A O   1 
ATOM   218  C  CB  . MET A 1 27  ? -9.078  -52.926 -2.323  1.00 11.41 ? 249  MET A CB  1 
ATOM   219  C  CG  . MET A 1 27  ? -10.547 -52.611 -2.120  1.00 14.15 ? 249  MET A CG  1 
ATOM   220  S  SD  . MET A 1 27  ? -11.580 -53.869 -2.874  1.00 19.85 ? 249  MET A SD  1 
ATOM   221  C  CE  . MET A 1 27  ? -11.386 -53.435 -4.619  1.00 20.88 ? 249  MET A CE  1 
ATOM   222  N  N   . VAL A 1 28  ? -6.233  -52.128 -1.167  1.00 12.55 ? 250  VAL A N   1 
ATOM   223  C  CA  . VAL A 1 28  ? -4.824  -52.464 -0.981  1.00 12.75 ? 250  VAL A CA  1 
ATOM   224  C  C   . VAL A 1 28  ? -4.667  -53.385 0.214   1.00 13.46 ? 250  VAL A C   1 
ATOM   225  O  O   . VAL A 1 28  ? -5.311  -53.197 1.251   1.00 14.24 ? 250  VAL A O   1 
ATOM   226  C  CB  . VAL A 1 28  ? -3.936  -51.209 -0.812  1.00 13.59 ? 250  VAL A CB  1 
ATOM   227  C  CG1 . VAL A 1 28  ? -4.381  -50.364 0.365   1.00 11.84 ? 250  VAL A CG1 1 
ATOM   228  C  CG2 . VAL A 1 28  ? -2.454  -51.606 -0.613  1.00 13.10 ? 250  VAL A CG2 1 
ATOM   229  N  N   A VAL A 1 29  ? -3.832  -54.408 0.062   0.92 12.85 ? 251  VAL A N   1 
ATOM   230  N  N   B VAL A 1 29  ? -3.800  -54.380 0.051   0.08 12.97 ? 251  VAL A N   1 
ATOM   231  C  CA  A VAL A 1 29  ? -3.314  -55.162 1.196   0.92 13.14 ? 251  VAL A CA  1 
ATOM   232  C  CA  B VAL A 1 29  ? -3.271  -55.200 1.130   0.08 13.29 ? 251  VAL A CA  1 
ATOM   233  C  C   A VAL A 1 29  ? -1.796  -55.025 1.160   0.92 14.86 ? 251  VAL A C   1 
ATOM   234  C  C   B VAL A 1 29  ? -1.761  -55.015 1.137   0.08 14.84 ? 251  VAL A C   1 
ATOM   235  O  O   A VAL A 1 29  ? -1.185  -55.095 0.091   0.92 14.95 ? 251  VAL A O   1 
ATOM   236  O  O   B VAL A 1 29  ? -1.123  -55.081 0.080   0.08 15.00 ? 251  VAL A O   1 
ATOM   237  C  CB  A VAL A 1 29  ? -3.780  -56.643 1.173   0.92 15.35 ? 251  VAL A CB  1 
ATOM   238  C  CB  B VAL A 1 29  ? -3.653  -56.677 0.944   0.08 15.37 ? 251  VAL A CB  1 
ATOM   239  C  CG1 A VAL A 1 29  ? -3.333  -57.360 -0.108  0.92 16.29 ? 251  VAL A CG1 1 
ATOM   240  C  CG1 B VAL A 1 29  ? -2.579  -57.585 1.483   0.08 15.72 ? 251  VAL A CG1 1 
ATOM   241  C  CG2 A VAL A 1 29  ? -3.308  -57.396 2.408   0.92 15.80 ? 251  VAL A CG2 1 
ATOM   242  C  CG2 B VAL A 1 29  ? -4.938  -56.944 1.639   0.08 13.28 ? 251  VAL A CG2 1 
ATOM   243  N  N   . ASP A 1 30  ? -1.191  -54.774 2.317   1.00 14.68 ? 252  ASP A N   1 
ATOM   244  C  CA  . ASP A 1 30  ? 0.224   -54.423 2.337   1.00 14.26 ? 252  ASP A CA  1 
ATOM   245  C  C   . ASP A 1 30  ? 0.806   -54.696 3.713   1.00 15.91 ? 252  ASP A C   1 
ATOM   246  O  O   . ASP A 1 30  ? 0.297   -54.171 4.708   1.00 15.44 ? 252  ASP A O   1 
ATOM   247  C  CB  . ASP A 1 30  ? 0.372   -52.943 1.971   1.00 15.11 ? 252  ASP A CB  1 
ATOM   248  C  CG  . ASP A 1 30  ? 1.806   -52.511 1.756   1.00 17.48 ? 252  ASP A CG  1 
ATOM   249  O  OD1 . ASP A 1 30  ? 2.753   -53.252 2.097   1.00 17.70 ? 252  ASP A OD1 1 
ATOM   250  O  OD2 . ASP A 1 30  ? 1.980   -51.400 1.222   1.00 18.39 ? 252  ASP A OD2 1 
ATOM   251  N  N   . PRO A 1 31  ? 1.873   -55.487 3.818   1.00 17.97 ? 253  PRO A N   1 
ATOM   252  C  CA  . PRO A 1 31  ? 2.510   -55.668 5.132   1.00 18.49 ? 253  PRO A CA  1 
ATOM   253  C  C   . PRO A 1 31  ? 3.106   -54.394 5.697   1.00 19.77 ? 253  PRO A C   1 
ATOM   254  O  O   . PRO A 1 31  ? 3.417   -54.358 6.892   1.00 20.42 ? 253  PRO A O   1 
ATOM   255  C  CB  . PRO A 1 31  ? 3.595   -56.720 4.855   1.00 23.73 ? 253  PRO A CB  1 
ATOM   256  C  CG  . PRO A 1 31  ? 3.886   -56.586 3.416   1.00 19.14 ? 253  PRO A CG  1 
ATOM   257  C  CD  . PRO A 1 31  ? 2.580   -56.225 2.758   1.00 18.46 ? 253  PRO A CD  1 
ATOM   258  N  N   . ASN A 1 32  ? 3.291   -53.352 4.886   1.00 17.28 ? 254  ASN A N   1 
ATOM   259  C  CA  . ASN A 1 32  ? 3.811   -52.090 5.387   1.00 18.59 ? 254  ASN A CA  1 
ATOM   260  C  C   . ASN A 1 32  ? 2.716   -51.084 5.722   1.00 20.81 ? 254  ASN A C   1 
ATOM   261  O  O   . ASN A 1 32  ? 3.029   -49.953 6.106   1.00 22.94 ? 254  ASN A O   1 
ATOM   262  C  CB  . ASN A 1 32  ? 4.810   -51.496 4.386   1.00 23.26 ? 254  ASN A CB  1 
ATOM   263  C  CG  . ASN A 1 32  ? 6.074   -52.347 4.261   1.00 34.92 ? 254  ASN A CG  1 
ATOM   264  O  OD1 . ASN A 1 32  ? 6.513   -52.675 3.160   1.00 53.97 ? 254  ASN A OD1 1 
ATOM   265  N  ND2 . ASN A 1 32  ? 6.641   -52.732 5.399   1.00 41.02 ? 254  ASN A ND2 1 
ATOM   266  N  N   . LEU A 1 33  ? 1.449   -51.464 5.598   1.00 17.35 ? 255  LEU A N   1 
ATOM   267  C  CA  . LEU A 1 33  ? 0.373   -50.694 6.212   1.00 14.32 ? 255  LEU A CA  1 
ATOM   268  C  C   . LEU A 1 33  ? 0.090   -51.254 7.597   1.00 16.06 ? 255  LEU A C   1 
ATOM   269  O  O   . LEU A 1 33  ? 0.495   -52.380 7.905   1.00 16.19 ? 255  LEU A O   1 
ATOM   270  C  CB  . LEU A 1 33  ? -0.887  -50.759 5.341   1.00 12.55 ? 255  LEU A CB  1 
ATOM   271  C  CG  . LEU A 1 33  ? -0.786  -50.028 3.998   1.00 15.08 ? 255  LEU A CG  1 
ATOM   272  C  CD1 . LEU A 1 33  ? -2.001  -50.358 3.123   1.00 15.14 ? 255  LEU A CD1 1 
ATOM   273  C  CD2 . LEU A 1 33  ? -0.649  -48.522 4.177   1.00 17.03 ? 255  LEU A CD2 1 
ATOM   274  N  N   . PRO A 1 34  ? -0.578  -50.497 8.470   1.00 15.48 ? 256  PRO A N   1 
ATOM   275  C  CA  . PRO A 1 34  ? -0.776  -50.979 9.844   1.00 16.20 ? 256  PRO A CA  1 
ATOM   276  C  C   . PRO A 1 34  ? -1.460  -52.335 9.854   1.00 17.00 ? 256  PRO A C   1 
ATOM   277  O  O   . PRO A 1 34  ? -2.415  -52.576 9.114   1.00 14.94 ? 256  PRO A O   1 
ATOM   278  C  CB  . PRO A 1 34  ? -1.649  -49.892 10.478  1.00 17.27 ? 256  PRO A CB  1 
ATOM   279  C  CG  . PRO A 1 34  ? -1.248  -48.666 9.762   1.00 18.92 ? 256  PRO A CG  1 
ATOM   280  C  CD  . PRO A 1 34  ? -1.025  -49.100 8.326   1.00 15.38 ? 256  PRO A CD  1 
ATOM   281  N  N   . LEU A 1 35  ? -0.936  -53.240 10.680  1.00 13.72 ? 257  LEU A N   1 
ATOM   282  C  CA  . LEU A 1 35  ? -1.489  -54.589 10.711  1.00 15.61 ? 257  LEU A CA  1 
ATOM   283  C  C   . LEU A 1 35  ? -2.854  -54.616 11.373  1.00 17.89 ? 257  LEU A C   1 
ATOM   284  O  O   . LEU A 1 35  ? -3.674  -55.487 11.061  1.00 20.24 ? 257  LEU A O   1 
ATOM   285  C  CB  . LEU A 1 35  ? -0.527  -55.531 11.435  1.00 17.80 ? 257  LEU A CB  1 
ATOM   286  C  CG  . LEU A 1 35  ? 0.847   -55.650 10.768  1.00 25.04 ? 257  LEU A CG  1 
ATOM   287  C  CD1 . LEU A 1 35  ? 1.696   -56.672 11.513  1.00 25.51 ? 257  LEU A CD1 1 
ATOM   288  C  CD2 . LEU A 1 35  ? 0.736   -56.019 9.287   1.00 24.97 ? 257  LEU A CD2 1 
ATOM   289  N  N   . GLN A 1 36  ? -3.109  -53.683 12.285  1.00 15.74 ? 258  GLN A N   1 
ATOM   290  C  CA  . GLN A 1 36  ? -4.411  -53.498 12.900  1.00 15.30 ? 258  GLN A CA  1 
ATOM   291  C  C   . GLN A 1 36  ? -4.892  -52.088 12.603  1.00 14.03 ? 258  GLN A C   1 
ATOM   292  O  O   . GLN A 1 36  ? -4.085  -51.172 12.444  1.00 16.54 ? 258  GLN A O   1 
ATOM   293  C  CB  . GLN A 1 36  ? -4.347  -53.716 14.422  1.00 16.41 ? 258  GLN A CB  1 
ATOM   294  C  CG  . GLN A 1 36  ? -3.686  -55.030 14.796  1.00 24.55 ? 258  GLN A CG  1 
ATOM   295  C  CD  . GLN A 1 36  ? -3.818  -55.353 16.273  1.00 38.45 ? 258  GLN A CD  1 
ATOM   296  O  OE1 . GLN A 1 36  ? -4.479  -54.630 17.023  1.00 32.63 ? 258  GLN A OE1 1 
ATOM   297  N  NE2 . GLN A 1 36  ? -3.180  -56.443 16.701  1.00 27.97 ? 258  GLN A NE2 1 
ATOM   298  N  N   . ALA A 1 37  ? -6.213  -51.925 12.520  1.00 13.91 ? 259  ALA A N   1 
ATOM   299  C  CA  . ALA A 1 37  ? -6.830  -50.644 12.199  1.00 12.06 ? 259  ALA A CA  1 
ATOM   300  C  C   . ALA A 1 37  ? -7.729  -50.206 13.344  1.00 12.94 ? 259  ALA A C   1 
ATOM   301  O  O   . ALA A 1 37  ? -8.462  -51.019 13.910  1.00 13.53 ? 259  ALA A O   1 
ATOM   302  C  CB  . ALA A 1 37  ? -7.653  -50.746 10.902  1.00 10.09 ? 259  ALA A CB  1 
ATOM   303  N  N   . ASN A 1 38  ? -7.692  -48.909 13.664  1.00 11.28 ? 260  ASN A N   1 
ATOM   304  C  CA  . ASN A 1 38  ? -8.452  -48.384 14.790  1.00 11.35 ? 260  ASN A CA  1 
ATOM   305  C  C   . ASN A 1 38  ? -9.390  -47.248 14.402  1.00 11.96 ? 260  ASN A C   1 
ATOM   306  O  O   . ASN A 1 38  ? -9.795  -46.471 15.272  1.00 12.78 ? 260  ASN A O   1 
ATOM   307  C  CB  . ASN A 1 38  ? -7.490  -47.936 15.890  1.00 14.33 ? 260  ASN A CB  1 
ATOM   308  C  CG  . ASN A 1 38  ? -6.872  -49.116 16.614  1.00 17.56 ? 260  ASN A CG  1 
ATOM   309  O  OD1 . ASN A 1 38  ? -7.496  -49.696 17.496  1.00 18.66 ? 260  ASN A OD1 1 
ATOM   310  N  ND2 . ASN A 1 38  ? -5.654  -49.490 16.229  1.00 18.34 ? 260  ASN A ND2 1 
ATOM   311  N  N   . PHE A 1 39  ? -9.764  -47.144 13.125  1.00 13.00 ? 261  PHE A N   1 
ATOM   312  C  CA  . PHE A 1 39  ? -10.641 -46.062 12.693  1.00 14.51 ? 261  PHE A CA  1 
ATOM   313  C  C   . PHE A 1 39  ? -11.927 -46.059 13.510  1.00 13.04 ? 261  PHE A C   1 
ATOM   314  O  O   . PHE A 1 39  ? -12.417 -47.107 13.943  1.00 12.68 ? 261  PHE A O   1 
ATOM   315  C  CB  . PHE A 1 39  ? -11.010 -46.213 11.215  1.00 9.21  ? 261  PHE A CB  1 
ATOM   316  C  CG  . PHE A 1 39  ? -9.845  -46.490 10.307  1.00 12.04 ? 261  PHE A CG  1 
ATOM   317  C  CD1 . PHE A 1 39  ? -8.653  -45.802 10.443  1.00 10.86 ? 261  PHE A CD1 1 
ATOM   318  C  CD2 . PHE A 1 39  ? -9.964  -47.437 9.300   1.00 11.85 ? 261  PHE A CD2 1 
ATOM   319  C  CE1 . PHE A 1 39  ? -7.573  -46.056 9.580   1.00 13.59 ? 261  PHE A CE1 1 
ATOM   320  C  CE2 . PHE A 1 39  ? -8.913  -47.703 8.440   1.00 11.56 ? 261  PHE A CE2 1 
ATOM   321  C  CZ  . PHE A 1 39  ? -7.710  -47.011 8.577   1.00 17.36 ? 261  PHE A CZ  1 
ATOM   322  N  N   . GLN A 1 40  ? -12.484 -44.864 13.708  1.00 11.42 ? 262  GLN A N   1 
ATOM   323  C  CA  . GLN A 1 40  ? -13.752 -44.732 14.411  1.00 9.23  ? 262  GLN A CA  1 
ATOM   324  C  C   . GLN A 1 40  ? -14.913 -44.476 13.468  1.00 11.32 ? 262  GLN A C   1 
ATOM   325  O  O   . GLN A 1 40  ? -16.069 -44.699 13.851  1.00 12.65 ? 262  GLN A O   1 
ATOM   326  C  CB  . GLN A 1 40  ? -13.662 -43.606 15.447  1.00 13.58 ? 262  GLN A CB  1 
ATOM   327  C  CG  . GLN A 1 40  ? -12.658 -43.935 16.550  1.00 11.47 ? 262  GLN A CG  1 
ATOM   328  C  CD  . GLN A 1 40  ? -13.003 -45.237 17.229  1.00 13.70 ? 262  GLN A CD  1 
ATOM   329  O  OE1 . GLN A 1 40  ? -14.097 -45.391 17.774  1.00 16.10 ? 262  GLN A OE1 1 
ATOM   330  N  NE2 . GLN A 1 40  ? -12.088 -46.191 17.184  1.00 12.70 ? 262  GLN A NE2 1 
ATOM   331  N  N   . ASN A 1 41  ? -14.632 -44.025 12.251  1.00 12.19 ? 263  ASN A N   1 
ATOM   332  C  CA  . ASN A 1 41  ? -15.639 -43.906 11.213  1.00 11.00 ? 263  ASN A CA  1 
ATOM   333  C  C   . ASN A 1 41  ? -15.562 -45.111 10.284  1.00 10.78 ? 263  ASN A C   1 
ATOM   334  O  O   . ASN A 1 41  ? -14.517 -45.753 10.150  1.00 13.10 ? 263  ASN A O   1 
ATOM   335  C  CB  . ASN A 1 41  ? -15.459 -42.594 10.439  1.00 11.33 ? 263  ASN A CB  1 
ATOM   336  C  CG  . ASN A 1 41  ? -15.908 -41.397 11.253  1.00 12.69 ? 263  ASN A CG  1 
ATOM   337  O  OD1 . ASN A 1 41  ? -16.906 -41.476 11.969  1.00 12.71 ? 263  ASN A OD1 1 
ATOM   338  N  ND2 . ASN A 1 41  ? -15.173 -40.290 11.161  1.00 13.22 ? 263  ASN A ND2 1 
ATOM   339  N  N   . GLY A 1 42  ? -16.695 -45.435 9.670   1.00 10.27 ? 264  GLY A N   1 
ATOM   340  C  CA  . GLY A 1 42  ? -16.756 -46.625 8.845   1.00 11.63 ? 264  GLY A CA  1 
ATOM   341  C  C   . GLY A 1 42  ? -16.698 -47.912 9.627   1.00 13.40 ? 264  GLY A C   1 
ATOM   342  O  O   . GLY A 1 42  ? -16.122 -48.895 9.142   1.00 13.67 ? 264  GLY A O   1 
ATOM   343  N  N   . ARG A 1 43  ? -17.279 -47.930 10.831  1.00 9.83  ? 265  ARG A N   1 
ATOM   344  C  CA  . ARG A 1 43  ? -17.276 -49.096 11.713  1.00 11.72 ? 265  ARG A CA  1 
ATOM   345  C  C   . ARG A 1 43  ? -18.712 -49.535 11.983  1.00 11.46 ? 265  ARG A C   1 
ATOM   346  O  O   . ARG A 1 43  ? -19.506 -48.774 12.544  1.00 12.25 ? 265  ARG A O   1 
ATOM   347  C  CB  . ARG A 1 43  ? -16.560 -48.793 13.036  1.00 10.24 ? 265  ARG A CB  1 
ATOM   348  C  CG  . ARG A 1 43  ? -15.122 -48.238 12.870  1.00 10.60 ? 265  ARG A CG  1 
ATOM   349  C  CD  . ARG A 1 43  ? -14.178 -49.238 12.167  1.00 12.32 ? 265  ARG A CD  1 
ATOM   350  N  NE  . ARG A 1 43  ? -14.123 -50.536 12.840  1.00 12.06 ? 265  ARG A NE  1 
ATOM   351  C  CZ  . ARG A 1 43  ? -13.281 -50.841 13.822  1.00 14.64 ? 265  ARG A CZ  1 
ATOM   352  N  NH1 . ARG A 1 43  ? -12.400 -49.960 14.280  1.00 14.58 ? 265  ARG A NH1 1 
ATOM   353  N  NH2 . ARG A 1 43  ? -13.324 -52.059 14.360  1.00 16.45 ? 265  ARG A NH2 1 
ATOM   354  N  N   . ILE A 1 44  ? -19.034 -50.762 11.600  1.00 13.26 ? 266  ILE A N   1 
ATOM   355  C  CA  . ILE A 1 44  ? -20.341 -51.347 11.880  1.00 11.16 ? 266  ILE A CA  1 
ATOM   356  C  C   . ILE A 1 44  ? -20.160 -52.855 11.904  1.00 11.19 ? 266  ILE A C   1 
ATOM   357  O  O   . ILE A 1 44  ? -19.307 -53.401 11.202  1.00 14.39 ? 266  ILE A O   1 
ATOM   358  C  CB  . ILE A 1 44  ? -21.390 -50.909 10.828  1.00 12.08 ? 266  ILE A CB  1 
ATOM   359  C  CG1 . ILE A 1 44  ? -22.805 -51.274 11.280  1.00 14.59 ? 266  ILE A CG1 1 
ATOM   360  C  CG2 . ILE A 1 44  ? -21.058 -51.495 9.447   1.00 12.95 ? 266  ILE A CG2 1 
ATOM   361  C  CD1 . ILE A 1 44  ? -23.908 -50.660 10.373  1.00 12.25 ? 266  ILE A CD1 1 
ATOM   362  N  N   . THR A 1 45  ? -20.940 -53.532 12.745  1.00 13.13 ? 267  THR A N   1 
ATOM   363  C  CA  . THR A 1 45  ? -20.954 -54.986 12.672  1.00 11.71 ? 267  THR A CA  1 
ATOM   364  C  C   . THR A 1 45  ? -21.741 -55.436 11.446  1.00 13.42 ? 267  THR A C   1 
ATOM   365  O  O   . THR A 1 45  ? -22.523 -54.678 10.866  1.00 13.76 ? 267  THR A O   1 
ATOM   366  C  CB  . THR A 1 45  ? -21.594 -55.600 13.918  1.00 14.79 ? 267  THR A CB  1 
ATOM   367  O  OG1 . THR A 1 45  ? -22.965 -55.197 13.979  1.00 14.03 ? 267  THR A OG1 1 
ATOM   368  C  CG2 . THR A 1 45  ? -20.882 -55.134 15.173  1.00 14.19 ? 267  THR A CG2 1 
ATOM   369  N  N   . LEU A 1 46  ? -21.541 -56.699 11.061  1.00 11.42 ? 268  LEU A N   1 
ATOM   370  C  CA  . LEU A 1 46  ? -22.267 -57.212 9.906   1.00 10.26 ? 268  LEU A CA  1 
ATOM   371  C  C   . LEU A 1 46  ? -23.765 -57.272 10.163  1.00 13.58 ? 268  LEU A C   1 
ATOM   372  O  O   . LEU A 1 46  ? -24.550 -57.206 9.211   1.00 14.43 ? 268  LEU A O   1 
ATOM   373  C  CB  . LEU A 1 46  ? -21.753 -58.592 9.512   1.00 12.49 ? 268  LEU A CB  1 
ATOM   374  C  CG  . LEU A 1 46  ? -20.274 -58.617 9.111   1.00 13.64 ? 268  LEU A CG  1 
ATOM   375  C  CD1 . LEU A 1 46  ? -19.910 -59.997 8.582   1.00 12.44 ? 268  LEU A CD1 1 
ATOM   376  C  CD2 . LEU A 1 46  ? -19.974 -57.538 8.070   1.00 11.54 ? 268  LEU A CD2 1 
ATOM   377  N  N   . ASP A 1 47  ? -24.189 -57.387 11.425  1.00 13.89 ? 269  ASP A N   1 
ATOM   378  C  CA  . ASP A 1 47  ? -25.621 -57.387 11.695  1.00 16.92 ? 269  ASP A CA  1 
ATOM   379  C  C   . ASP A 1 47  ? -26.163 -55.986 11.959  1.00 19.52 ? 269  ASP A C   1 
ATOM   380  O  O   . ASP A 1 47  ? -27.320 -55.842 12.364  1.00 16.77 ? 269  ASP A O   1 
ATOM   381  C  CB  . ASP A 1 47  ? -25.980 -58.376 12.831  1.00 18.27 ? 269  ASP A CB  1 
ATOM   382  C  CG  . ASP A 1 47  ? -25.387 -58.026 14.190  1.00 24.53 ? 269  ASP A CG  1 
ATOM   383  O  OD1 . ASP A 1 47  ? -24.863 -56.921 14.409  1.00 21.08 ? 269  ASP A OD1 1 
ATOM   384  O  OD2 . ASP A 1 47  ? -25.476 -58.905 15.078  1.00 27.51 ? 269  ASP A OD2 1 
ATOM   385  N  N   . GLY A 1 48  ? -25.373 -54.954 11.688  1.00 14.23 ? 270  GLY A N   1 
ATOM   386  C  CA  . GLY A 1 48  ? -25.887 -53.604 11.584  1.00 13.97 ? 270  GLY A CA  1 
ATOM   387  C  C   . GLY A 1 48  ? -25.767 -52.737 12.814  1.00 17.15 ? 270  GLY A C   1 
ATOM   388  O  O   . GLY A 1 48  ? -26.520 -51.764 12.927  1.00 14.69 ? 270  GLY A O   1 
ATOM   389  N  N   . GLU A 1 49  ? -24.844 -53.035 13.726  1.00 13.51 ? 271  GLU A N   1 
ATOM   390  C  CA  . GLU A 1 49  ? -24.645 -52.228 14.924  1.00 13.67 ? 271  GLU A CA  1 
ATOM   391  C  C   . GLU A 1 49  ? -23.509 -51.237 14.673  1.00 15.24 ? 271  GLU A C   1 
ATOM   392  O  O   . GLU A 1 49  ? -22.343 -51.633 14.568  1.00 12.98 ? 271  GLU A O   1 
ATOM   393  C  CB  . GLU A 1 49  ? -24.345 -53.114 16.134  1.00 14.59 ? 271  GLU A CB  1 
ATOM   394  C  CG  . GLU A 1 49  ? -24.172 -52.327 17.423  1.00 19.33 ? 271  GLU A CG  1 
ATOM   395  C  CD  . GLU A 1 49  ? -23.741 -53.209 18.597  1.00 38.89 ? 271  GLU A CD  1 
ATOM   396  O  OE1 . GLU A 1 49  ? -23.712 -54.448 18.439  1.00 34.67 ? 271  GLU A OE1 1 
ATOM   397  O  OE2 . GLU A 1 49  ? -23.430 -52.662 19.674  1.00 47.01 ? 271  GLU A OE2 1 
ATOM   398  N  N   . LEU A 1 50  ? -23.854 -49.953 14.589  1.00 13.77 ? 272  LEU A N   1 
ATOM   399  C  CA  . LEU A 1 50  ? -22.861 -48.904 14.407  1.00 11.13 ? 272  LEU A CA  1 
ATOM   400  C  C   . LEU A 1 50  ? -21.909 -48.859 15.594  1.00 15.23 ? 272  LEU A C   1 
ATOM   401  O  O   . LEU A 1 50  ? -22.303 -49.088 16.741  1.00 13.80 ? 272  LEU A O   1 
ATOM   402  C  CB  . LEU A 1 50  ? -23.550 -47.541 14.265  1.00 11.56 ? 272  LEU A CB  1 
ATOM   403  C  CG  . LEU A 1 50  ? -24.456 -47.440 13.035  1.00 12.72 ? 272  LEU A CG  1 
ATOM   404  C  CD1 . LEU A 1 50  ? -25.412 -46.260 13.159  1.00 13.94 ? 272  LEU A CD1 1 
ATOM   405  C  CD2 . LEU A 1 50  ? -23.604 -47.312 11.777  1.00 14.72 ? 272  LEU A CD2 1 
ATOM   406  N  N   . GLN A 1 51  ? -20.652 -48.533 15.316  1.00 12.57 ? 273  GLN A N   1 
ATOM   407  C  CA  A GLN A 1 51  ? -19.616 -48.463 16.337  0.63 13.82 ? 273  GLN A CA  1 
ATOM   408  C  CA  B GLN A 1 51  ? -19.620 -48.464 16.339  0.37 13.88 ? 273  GLN A CA  1 
ATOM   409  C  C   . GLN A 1 51  ? -18.865 -47.149 16.216  1.00 16.41 ? 273  GLN A C   1 
ATOM   410  O  O   . GLN A 1 51  ? -18.931 -46.464 15.193  1.00 13.54 ? 273  GLN A O   1 
ATOM   411  C  CB  A GLN A 1 51  ? -18.607 -49.609 16.213  0.63 15.47 ? 273  GLN A CB  1 
ATOM   412  C  CB  B GLN A 1 51  ? -18.637 -49.640 16.225  0.37 15.51 ? 273  GLN A CB  1 
ATOM   413  C  CG  A GLN A 1 51  ? -19.197 -50.997 16.204  0.63 16.55 ? 273  GLN A CG  1 
ATOM   414  C  CG  B GLN A 1 51  ? -19.296 -51.006 16.093  0.37 16.64 ? 273  GLN A CG  1 
ATOM   415  C  CD  A GLN A 1 51  ? -18.148 -52.034 15.868  0.63 23.29 ? 273  GLN A CD  1 
ATOM   416  C  CD  B GLN A 1 51  ? -19.990 -51.450 17.364  0.37 21.30 ? 273  GLN A CD  1 
ATOM   417  O  OE1 A GLN A 1 51  ? -17.140 -52.156 16.559  0.63 22.95 ? 273  GLN A OE1 1 
ATOM   418  O  OE1 B GLN A 1 51  ? -19.724 -50.928 18.445  0.37 26.29 ? 273  GLN A OE1 1 
ATOM   419  N  NE2 A GLN A 1 51  ? -18.362 -52.765 14.783  0.63 23.55 ? 273  GLN A NE2 1 
ATOM   420  N  NE2 B GLN A 1 51  ? -20.887 -52.422 17.240  0.37 23.63 ? 273  GLN A NE2 1 
ATOM   421  N  N   . GLY A 1 52  ? -18.126 -46.815 17.272  1.00 12.19 ? 274  GLY A N   1 
ATOM   422  C  CA  . GLY A 1 52  ? -17.258 -45.649 17.212  1.00 11.86 ? 274  GLY A CA  1 
ATOM   423  C  C   . GLY A 1 52  ? -18.047 -44.366 17.045  1.00 13.85 ? 274  GLY A C   1 
ATOM   424  O  O   . GLY A 1 52  ? -18.952 -44.054 17.830  1.00 15.06 ? 274  GLY A O   1 
ATOM   425  N  N   . THR A 1 53  ? -17.685 -43.596 16.024  1.00 14.02 ? 275  THR A N   1 
ATOM   426  C  CA  . THR A 1 53  ? -18.389 -42.368 15.669  1.00 13.21 ? 275  THR A CA  1 
ATOM   427  C  C   . THR A 1 53  ? -19.107 -42.509 14.329  1.00 13.37 ? 275  THR A C   1 
ATOM   428  O  O   . THR A 1 53  ? -19.341 -41.520 13.641  1.00 13.71 ? 275  THR A O   1 
ATOM   429  C  CB  . THR A 1 53  ? -17.424 -41.178 15.637  1.00 14.34 ? 275  THR A CB  1 
ATOM   430  O  OG1 . THR A 1 53  ? -16.382 -41.424 14.679  1.00 15.50 ? 275  THR A OG1 1 
ATOM   431  C  CG2 . THR A 1 53  ? -16.785 -40.960 17.017  1.00 12.68 ? 275  THR A CG2 1 
ATOM   432  N  N   . THR A 1 54  ? -19.467 -43.734 13.950  1.00 11.50 ? 276  THR A N   1 
ATOM   433  C  CA  . THR A 1 54  ? -19.877 -43.992 12.567  1.00 11.17 ? 276  THR A CA  1 
ATOM   434  C  C   . THR A 1 54  ? -21.331 -43.595 12.328  1.00 13.60 ? 276  THR A C   1 
ATOM   435  O  O   . THR A 1 54  ? -22.236 -44.051 13.034  1.00 12.98 ? 276  THR A O   1 
ATOM   436  C  CB  . THR A 1 54  ? -19.666 -45.466 12.238  1.00 9.33  ? 276  THR A CB  1 
ATOM   437  O  OG1 . THR A 1 54  ? -18.260 -45.734 12.270  1.00 13.33 ? 276  THR A OG1 1 
ATOM   438  C  CG2 . THR A 1 54  ? -20.212 -45.813 10.837  1.00 9.92  ? 276  THR A CG2 1 
ATOM   439  N  N   . LEU A 1 55  ? -21.539 -42.736 11.328  1.00 11.36 ? 277  LEU A N   1 
ATOM   440  C  CA  . LEU A 1 55  ? -22.872 -42.421 10.826  1.00 14.56 ? 277  LEU A CA  1 
ATOM   441  C  C   . LEU A 1 55  ? -23.421 -43.567 9.975   1.00 12.08 ? 277  LEU A C   1 
ATOM   442  O  O   . LEU A 1 55  ? -22.669 -44.250 9.285   1.00 12.85 ? 277  LEU A O   1 
ATOM   443  C  CB  . LEU A 1 55  ? -22.829 -41.162 9.961   1.00 12.72 ? 277  LEU A CB  1 
ATOM   444  C  CG  . LEU A 1 55  ? -22.479 -39.845 10.649  1.00 13.87 ? 277  LEU A CG  1 
ATOM   445  C  CD1 . LEU A 1 55  ? -21.973 -38.820 9.614   1.00 13.14 ? 277  LEU A CD1 1 
ATOM   446  C  CD2 . LEU A 1 55  ? -23.696 -39.328 11.404  1.00 13.76 ? 277  LEU A CD2 1 
ATOM   447  N  N   . PRO A 1 56  ? -24.741 -43.752 9.954   1.00 13.01 ? 278  PRO A N   1 
ATOM   448  C  CA  . PRO A 1 56  ? -25.313 -44.813 9.111   1.00 13.26 ? 278  PRO A CA  1 
ATOM   449  C  C   . PRO A 1 56  ? -25.283 -44.500 7.618   1.00 10.14 ? 278  PRO A C   1 
ATOM   450  O  O   . PRO A 1 56  ? -25.292 -45.432 6.800   1.00 13.16 ? 278  PRO A O   1 
ATOM   451  C  CB  . PRO A 1 56  ? -26.751 -44.924 9.633   1.00 14.37 ? 278  PRO A CB  1 
ATOM   452  C  CG  . PRO A 1 56  ? -27.063 -43.544 10.156  1.00 14.65 ? 278  PRO A CG  1 
ATOM   453  C  CD  . PRO A 1 56  ? -25.762 -43.070 10.774  1.00 14.62 ? 278  PRO A CD  1 
ATOM   454  N  N   . THR A 1 57  ? -25.281 -43.219 7.245   1.00 13.10 ? 279  THR A N   1 
ATOM   455  C  CA  . THR A 1 57  ? -25.299 -42.768 5.857   1.00 10.64 ? 279  THR A CA  1 
ATOM   456  C  C   . THR A 1 57  ? -24.334 -41.594 5.723   1.00 12.63 ? 279  THR A C   1 
ATOM   457  O  O   . THR A 1 57  ? -23.838 -41.061 6.716   1.00 12.96 ? 279  THR A O   1 
ATOM   458  C  CB  . THR A 1 57  ? -26.710 -42.333 5.428   1.00 11.35 ? 279  THR A CB  1 
ATOM   459  O  OG1 . THR A 1 57  ? -27.209 -41.410 6.400   1.00 13.19 ? 279  THR A OG1 1 
ATOM   460  C  CG2 . THR A 1 57  ? -27.650 -43.524 5.375   1.00 11.94 ? 279  THR A CG2 1 
ATOM   461  N  N   . SER A 1 58  ? -24.106 -41.138 4.491   1.00 12.63 ? 280  SER A N   1 
ATOM   462  C  CA  A SER A 1 58  ? -23.125 -40.083 4.216   0.57 13.83 ? 280  SER A CA  1 
ATOM   463  C  CA  B SER A 1 58  ? -23.114 -40.086 4.247   0.28 13.86 ? 280  SER A CA  1 
ATOM   464  C  CA  C SER A 1 58  ? -23.117 -40.086 4.238   0.15 13.88 ? 280  SER A CA  1 
ATOM   465  C  C   . SER A 1 58  ? -23.736 -38.696 4.394   1.00 16.31 ? 280  SER A C   1 
ATOM   466  O  O   . SER A 1 58  ? -23.709 -37.853 3.493   1.00 15.29 ? 280  SER A O   1 
ATOM   467  C  CB  A SER A 1 58  ? -22.567 -40.235 2.805   0.57 16.14 ? 280  SER A CB  1 
ATOM   468  C  CB  B SER A 1 58  ? -22.481 -40.271 2.874   0.28 16.14 ? 280  SER A CB  1 
ATOM   469  C  CB  C SER A 1 58  ? -22.502 -40.267 2.855   0.15 16.14 ? 280  SER A CB  1 
ATOM   470  O  OG  A SER A 1 58  ? -21.989 -41.502 2.606   0.57 13.88 ? 280  SER A OG  1 
ATOM   471  O  OG  B SER A 1 58  ? -23.469 -40.241 1.866   0.28 13.38 ? 280  SER A OG  1 
ATOM   472  O  OG  C SER A 1 58  ? -21.441 -39.350 2.653   0.15 16.69 ? 280  SER A OG  1 
ATOM   473  N  N   . THR A 1 59  ? -24.280 -38.444 5.585   1.00 14.60 ? 281  THR A N   1 
ATOM   474  C  CA  . THR A 1 59  ? -24.896 -37.142 5.798   1.00 14.23 ? 281  THR A CA  1 
ATOM   475  C  C   . THR A 1 59  ? -23.866 -36.065 6.111   1.00 15.27 ? 281  THR A C   1 
ATOM   476  O  O   . THR A 1 59  ? -23.998 -34.924 5.652   1.00 20.05 ? 281  THR A O   1 
ATOM   477  C  CB  . THR A 1 59  ? -25.923 -37.221 6.927   1.00 12.00 ? 281  THR A CB  1 
ATOM   478  O  OG1 . THR A 1 59  ? -25.332 -37.853 8.072   1.00 14.60 ? 281  THR A OG1 1 
ATOM   479  C  CG2 . THR A 1 59  ? -27.142 -38.004 6.479   1.00 11.57 ? 281  THR A CG2 1 
ATOM   480  N  N   . SER A 1 60  ? -22.844 -36.396 6.892   1.00 12.26 ? 282  SER A N   1 
ATOM   481  C  CA  . SER A 1 60  ? -21.981 -35.357 7.435   1.00 12.08 ? 282  SER A CA  1 
ATOM   482  C  C   . SER A 1 60  ? -20.621 -35.904 7.832   1.00 13.23 ? 282  SER A C   1 
ATOM   483  O  O   . SER A 1 60  ? -20.049 -35.482 8.840   1.00 13.98 ? 282  SER A O   1 
ATOM   484  C  CB  . SER A 1 60  ? -22.650 -34.707 8.649   1.00 14.31 ? 282  SER A CB  1 
ATOM   485  O  OG  . SER A 1 60  ? -22.897 -35.686 9.643   1.00 13.92 ? 282  SER A OG  1 
ATOM   486  N  N   . ILE A 1 61  ? -20.102 -36.857 7.057   1.00 12.78 ? 283  ILE A N   1 
ATOM   487  C  CA  . ILE A 1 61  ? -18.804 -37.438 7.379   1.00 10.21 ? 283  ILE A CA  1 
ATOM   488  C  C   . ILE A 1 61  ? -17.734 -36.363 7.325   1.00 15.01 ? 283  ILE A C   1 
ATOM   489  O  O   . ILE A 1 61  ? -17.617 -35.627 6.335   1.00 14.95 ? 283  ILE A O   1 
ATOM   490  C  CB  . ILE A 1 61  ? -18.485 -38.584 6.407   1.00 13.84 ? 283  ILE A CB  1 
ATOM   491  C  CG1 . ILE A 1 61  ? -19.516 -39.697 6.562   1.00 13.50 ? 283  ILE A CG1 1 
ATOM   492  C  CG2 . ILE A 1 61  ? -17.076 -39.128 6.664   1.00 16.57 ? 283  ILE A CG2 1 
ATOM   493  C  CD1 . ILE A 1 61  ? -19.438 -40.762 5.448   1.00 17.53 ? 283  ILE A CD1 1 
ATOM   494  N  N   . GLY A 1 62  ? -16.930 -36.283 8.386   1.00 12.81 ? 284  GLY A N   1 
ATOM   495  C  CA  . GLY A 1 62  ? -15.859 -35.312 8.479   1.00 13.74 ? 284  GLY A CA  1 
ATOM   496  C  C   . GLY A 1 62  ? -16.275 -33.963 9.019   1.00 11.46 ? 284  GLY A C   1 
ATOM   497  O  O   . GLY A 1 62  ? -15.412 -33.096 9.210   1.00 12.34 ? 284  GLY A O   1 
ATOM   498  N  N   . ARG A 1 63  ? -17.562 -33.757 9.282   1.00 11.68 ? 285  ARG A N   1 
ATOM   499  C  CA  . ARG A 1 63  ? -18.038 -32.477 9.784   1.00 11.13 ? 285  ARG A CA  1 
ATOM   500  C  C   . ARG A 1 63  ? -18.125 -32.477 11.306  1.00 11.81 ? 285  ARG A C   1 
ATOM   501  O  O   . ARG A 1 63  ? -18.251 -33.526 11.937  1.00 12.98 ? 285  ARG A O   1 
ATOM   502  C  CB  . ARG A 1 63  ? -19.414 -32.154 9.195   1.00 11.70 ? 285  ARG A CB  1 
ATOM   503  C  CG  . ARG A 1 63  ? -19.424 -32.182 7.670   1.00 11.21 ? 285  ARG A CG  1 
ATOM   504  C  CD  . ARG A 1 63  ? -20.656 -31.511 7.095   1.00 13.62 ? 285  ARG A CD  1 
ATOM   505  N  NE  . ARG A 1 63  ? -20.692 -31.739 5.652   1.00 12.08 ? 285  ARG A NE  1 
ATOM   506  C  CZ  . ARG A 1 63  ? -21.271 -30.927 4.783   1.00 13.93 ? 285  ARG A CZ  1 
ATOM   507  N  NH1 . ARG A 1 63  ? -21.916 -29.840 5.181   1.00 13.91 ? 285  ARG A NH1 1 
ATOM   508  N  NH2 . ARG A 1 63  ? -21.174 -31.197 3.482   1.00 14.08 ? 285  ARG A NH2 1 
ATOM   509  N  N   . ILE A 1 64  ? -18.051 -31.275 11.896  1.00 11.38 ? 286  ILE A N   1 
ATOM   510  C  CA  . ILE A 1 64  ? -18.465 -31.065 13.281  1.00 11.59 ? 286  ILE A CA  1 
ATOM   511  C  C   . ILE A 1 64  ? -19.436 -29.891 13.307  1.00 12.46 ? 286  ILE A C   1 
ATOM   512  O  O   . ILE A 1 64  ? -19.421 -29.021 12.434  1.00 15.33 ? 286  ILE A O   1 
ATOM   513  C  CB  . ILE A 1 64  ? -17.287 -30.810 14.251  1.00 12.44 ? 286  ILE A CB  1 
ATOM   514  C  CG1 . ILE A 1 64  ? -16.513 -29.556 13.863  1.00 13.51 ? 286  ILE A CG1 1 
ATOM   515  C  CG2 . ILE A 1 64  ? -16.369 -32.050 14.346  1.00 12.35 ? 286  ILE A CG2 1 
ATOM   516  C  CD1 . ILE A 1 64  ? -15.544 -29.117 14.968  1.00 17.33 ? 286  ILE A CD1 1 
ATOM   517  N  N   . SER A 1 65  ? -20.292 -29.878 14.330  1.00 11.19 ? 287  SER A N   1 
ATOM   518  C  CA  . SER A 1 65  ? -21.388 -28.919 14.396  1.00 12.01 ? 287  SER A CA  1 
ATOM   519  C  C   . SER A 1 65  ? -21.606 -28.496 15.838  1.00 13.71 ? 287  SER A C   1 
ATOM   520  O  O   . SER A 1 65  ? -21.280 -29.226 16.770  1.00 12.64 ? 287  SER A O   1 
ATOM   521  C  CB  . SER A 1 65  ? -22.711 -29.495 13.878  1.00 14.32 ? 287  SER A CB  1 
ATOM   522  O  OG  . SER A 1 65  ? -22.593 -29.986 12.563  1.00 15.15 ? 287  SER A OG  1 
ATOM   523  N  N   . GLY A 1 66  ? -22.219 -27.332 16.007  1.00 15.25 ? 288  GLY A N   1 
ATOM   524  C  CA  . GLY A 1 66  ? -22.586 -26.903 17.345  1.00 18.01 ? 288  GLY A CA  1 
ATOM   525  C  C   . GLY A 1 66  ? -23.057 -25.468 17.321  1.00 14.56 ? 288  GLY A C   1 
ATOM   526  O  O   . GLY A 1 66  ? -23.456 -24.955 16.279  1.00 16.05 ? 288  GLY A O   1 
ATOM   527  N  N   . THR A 1 67  ? -23.009 -24.831 18.487  1.00 16.38 ? 289  THR A N   1 
ATOM   528  C  CA  . THR A 1 67  ? -23.415 -23.441 18.604  1.00 17.52 ? 289  THR A CA  1 
ATOM   529  C  C   . THR A 1 67  ? -22.215 -22.595 19.003  1.00 21.49 ? 289  THR A C   1 
ATOM   530  O  O   . THR A 1 67  ? -21.340 -23.045 19.749  1.00 20.16 ? 289  THR A O   1 
ATOM   531  C  CB  . THR A 1 67  ? -24.551 -23.278 19.610  1.00 19.60 ? 289  THR A CB  1 
ATOM   532  O  OG1 . THR A 1 67  ? -24.117 -23.744 20.887  1.00 20.72 ? 289  THR A OG1 1 
ATOM   533  C  CG2 . THR A 1 67  ? -25.759 -24.090 19.172  1.00 20.98 ? 289  THR A CG2 1 
ATOM   534  N  N   . TYR A 1 68  ? -22.179 -21.374 18.482  1.00 17.58 ? 290  TYR A N   1 
ATOM   535  C  CA  . TYR A 1 68  ? -21.030 -20.505 18.671  1.00 16.49 ? 290  TYR A CA  1 
ATOM   536  C  C   . TYR A 1 68  ? -20.935 -20.064 20.125  1.00 19.70 ? 290  TYR A C   1 
ATOM   537  O  O   . TYR A 1 68  ? -21.943 -19.729 20.747  1.00 19.81 ? 290  TYR A O   1 
ATOM   538  C  CB  . TYR A 1 68  ? -21.152 -19.286 17.762  1.00 18.59 ? 290  TYR A CB  1 
ATOM   539  C  CG  . TYR A 1 68  ? -20.063 -18.274 17.964  1.00 22.32 ? 290  TYR A CG  1 
ATOM   540  C  CD1 . TYR A 1 68  ? -18.763 -18.541 17.560  1.00 23.30 ? 290  TYR A CD1 1 
ATOM   541  C  CD2 . TYR A 1 68  ? -20.333 -17.047 18.549  1.00 21.27 ? 290  TYR A CD2 1 
ATOM   542  C  CE1 . TYR A 1 68  ? -17.760 -17.613 17.737  1.00 23.74 ? 290  TYR A CE1 1 
ATOM   543  C  CE2 . TYR A 1 68  ? -19.336 -16.111 18.731  1.00 22.43 ? 290  TYR A CE2 1 
ATOM   544  C  CZ  . TYR A 1 68  ? -18.054 -16.400 18.328  1.00 26.31 ? 290  TYR A CZ  1 
ATOM   545  O  OH  . TYR A 1 68  ? -17.056 -15.475 18.504  1.00 24.48 ? 290  TYR A OH  1 
ATOM   546  N  N   . MET A 1 69  ? -19.716 -20.086 20.660  1.00 17.88 ? 291  MET A N   1 
ATOM   547  C  CA  . MET A 1 69  ? -19.405 -19.589 22.000  1.00 19.11 ? 291  MET A CA  1 
ATOM   548  C  C   . MET A 1 69  ? -18.561 -18.329 21.863  1.00 21.79 ? 291  MET A C   1 
ATOM   549  O  O   . MET A 1 69  ? -17.451 -18.380 21.328  1.00 24.62 ? 291  MET A O   1 
ATOM   550  C  CB  . MET A 1 69  ? -18.656 -20.642 22.813  1.00 21.30 ? 291  MET A CB  1 
ATOM   551  C  CG  . MET A 1 69  ? -19.402 -21.947 22.971  1.00 21.16 ? 291  MET A CG  1 
ATOM   552  S  SD  . MET A 1 69  ? -18.362 -23.233 23.689  1.00 28.57 ? 291  MET A SD  1 
ATOM   553  C  CE  . MET A 1 69  ? -18.358 -22.751 25.420  1.00 33.40 ? 291  MET A CE  1 
ATOM   554  N  N   . SER A 1 70  ? -19.085 -17.195 22.336  1.00 26.18 ? 292  SER A N   1 
ATOM   555  C  CA  . SER A 1 70  ? -18.315 -15.960 22.242  1.00 36.10 ? 292  SER A CA  1 
ATOM   556  C  C   . SER A 1 70  ? -17.118 -15.938 23.188  1.00 46.25 ? 292  SER A C   1 
ATOM   557  O  O   . SER A 1 70  ? -16.316 -15.001 23.122  1.00 51.10 ? 292  SER A O   1 
ATOM   558  C  CB  . SER A 1 70  ? -19.221 -14.757 22.510  1.00 35.98 ? 292  SER A CB  1 
ATOM   559  O  OG  . SER A 1 70  ? -19.938 -14.933 23.716  1.00 45.96 ? 292  SER A OG  1 
ATOM   560  N  N   . SER A 1 71  ? -16.973 -16.942 24.050  1.00 44.74 ? 293  SER A N   1 
ATOM   561  C  CA  . SER A 1 71  ? -15.844 -17.035 24.964  1.00 65.20 ? 293  SER A CA  1 
ATOM   562  C  C   . SER A 1 71  ? -15.307 -18.460 24.975  1.00 57.29 ? 293  SER A C   1 
ATOM   563  O  O   . SER A 1 71  ? -16.060 -19.428 24.834  1.00 52.21 ? 293  SER A O   1 
ATOM   564  C  CB  . SER A 1 71  ? -16.232 -16.620 26.394  1.00 64.04 ? 293  SER A CB  1 
ATOM   565  O  OG  . SER A 1 71  ? -16.726 -15.293 26.434  1.00 63.41 ? 293  SER A OG  1 
ATOM   566  N  N   . THR A 1 72  ? -13.992 -18.576 25.148  1.00 51.61 ? 294  THR A N   1 
ATOM   567  C  CA  . THR A 1 72  ? -13.366 -19.877 25.330  1.00 53.60 ? 294  THR A CA  1 
ATOM   568  C  C   . THR A 1 72  ? -13.943 -20.572 26.567  1.00 60.70 ? 294  THR A C   1 
ATOM   569  O  O   . THR A 1 72  ? -14.336 -19.909 27.533  1.00 64.78 ? 294  THR A O   1 
ATOM   570  C  CB  . THR A 1 72  ? -11.849 -19.712 25.465  1.00 56.91 ? 294  THR A CB  1 
ATOM   571  O  OG1 . THR A 1 72  ? -11.266 -20.906 26.007  1.00 57.32 ? 294  THR A OG1 1 
ATOM   572  C  CG2 . THR A 1 72  ? -11.516 -18.534 26.368  1.00 60.73 ? 294  THR A CG2 1 
ATOM   573  N  N   A PRO A 1 73  ? -14.008 -21.915 26.563  0.45 54.93 ? 295  PRO A N   1 
ATOM   574  N  N   B PRO A 1 73  ? -14.040 -21.914 26.550  0.55 54.93 ? 295  PRO A N   1 
ATOM   575  C  CA  A PRO A 1 73  ? -14.434 -22.701 27.728  0.45 56.63 ? 295  PRO A CA  1 
ATOM   576  C  CA  B PRO A 1 73  ? -14.561 -22.706 27.674  0.55 56.62 ? 295  PRO A CA  1 
ATOM   577  C  C   A PRO A 1 73  ? -13.634 -22.383 28.992  0.45 52.34 ? 295  PRO A C   1 
ATOM   578  C  C   B PRO A 1 73  ? -13.918 -22.366 29.020  0.55 52.47 ? 295  PRO A C   1 
ATOM   579  O  O   A PRO A 1 73  ? -12.506 -22.859 29.128  0.45 47.42 ? 295  PRO A O   1 
ATOM   580  O  O   B PRO A 1 73  ? -14.645 -22.040 29.959  0.55 50.53 ? 295  PRO A O   1 
ATOM   581  C  CB  A PRO A 1 73  ? -14.184 -24.145 27.282  0.45 51.18 ? 295  PRO A CB  1 
ATOM   582  C  CB  B PRO A 1 73  ? -14.224 -24.143 27.266  0.55 51.21 ? 295  PRO A CB  1 
ATOM   583  C  CG  A PRO A 1 73  ? -14.318 -24.101 25.805  0.45 44.53 ? 295  PRO A CG  1 
ATOM   584  C  CG  B PRO A 1 73  ? -14.255 -24.114 25.785  0.55 44.54 ? 295  PRO A CG  1 
ATOM   585  C  CD  A PRO A 1 73  ? -13.763 -22.768 25.387  0.45 44.65 ? 295  PRO A CD  1 
ATOM   586  C  CD  B PRO A 1 73  ? -13.724 -22.763 25.387  0.55 44.63 ? 295  PRO A CD  1 
ATOM   587  N  N   . ARG A 1 89  ? -1.567  -14.310 7.720   1.00 68.73 ? 311  ARG A N   1 
ATOM   588  C  CA  . ARG A 1 89  ? -2.712  -13.764 8.442   1.00 67.25 ? 311  ARG A CA  1 
ATOM   589  C  C   . ARG A 1 89  ? -2.798  -14.340 9.850   1.00 54.60 ? 311  ARG A C   1 
ATOM   590  O  O   . ARG A 1 89  ? -2.051  -15.259 10.198  1.00 53.38 ? 311  ARG A O   1 
ATOM   591  C  CB  . ARG A 1 89  ? -4.015  -14.038 7.686   1.00 60.91 ? 311  ARG A CB  1 
ATOM   592  C  CG  . ARG A 1 89  ? -4.099  -13.381 6.317   1.00 70.73 ? 311  ARG A CG  1 
ATOM   593  C  CD  . ARG A 1 89  ? -3.615  -14.317 5.222   1.00 73.69 ? 311  ARG A CD  1 
ATOM   594  N  NE  . ARG A 1 89  ? -4.417  -15.533 5.162   1.00 73.77 ? 311  ARG A NE  1 
ATOM   595  C  CZ  . ARG A 1 89  ? -5.535  -15.659 4.461   1.00 70.16 ? 311  ARG A CZ  1 
ATOM   596  N  NH1 . ARG A 1 89  ? -6.011  -14.660 3.735   1.00 69.39 ? 311  ARG A NH1 1 
ATOM   597  N  NH2 . ARG A 1 89  ? -6.191  -16.816 4.488   1.00 58.79 ? 311  ARG A NH2 1 
ATOM   598  N  N   . VAL A 1 90  ? -3.712  -13.797 10.652  1.00 47.77 ? 312  VAL A N   1 
ATOM   599  C  CA  . VAL A 1 90  ? -3.908  -14.209 12.040  1.00 47.91 ? 312  VAL A CA  1 
ATOM   600  C  C   . VAL A 1 90  ? -5.245  -14.936 12.143  1.00 38.23 ? 312  VAL A C   1 
ATOM   601  O  O   . VAL A 1 90  ? -6.304  -14.364 11.854  1.00 34.94 ? 312  VAL A O   1 
ATOM   602  C  CB  . VAL A 1 90  ? -3.846  -13.013 13.003  1.00 54.38 ? 312  VAL A CB  1 
ATOM   603  C  CG1 . VAL A 1 90  ? -4.604  -11.818 12.429  1.00 66.01 ? 312  VAL A CG1 1 
ATOM   604  C  CG2 . VAL A 1 90  ? -4.391  -13.404 14.373  1.00 47.38 ? 312  VAL A CG2 1 
ATOM   605  N  N   . PHE A 1 91  ? -5.194  -16.195 12.560  1.00 39.59 ? 313  PHE A N   1 
ATOM   606  C  CA  . PHE A 1 91  ? -6.361  -17.068 12.600  1.00 35.28 ? 313  PHE A CA  1 
ATOM   607  C  C   . PHE A 1 91  ? -6.810  -17.232 14.045  1.00 36.49 ? 313  PHE A C   1 
ATOM   608  O  O   . PHE A 1 91  ? -6.094  -17.817 14.864  1.00 45.16 ? 313  PHE A O   1 
ATOM   609  C  CB  . PHE A 1 91  ? -6.037  -18.413 11.958  1.00 31.53 ? 313  PHE A CB  1 
ATOM   610  C  CG  . PHE A 1 91  ? -5.750  -18.313 10.492  1.00 34.40 ? 313  PHE A CG  1 
ATOM   611  C  CD1 . PHE A 1 91  ? -4.462  -18.083 10.039  1.00 39.83 ? 313  PHE A CD1 1 
ATOM   612  C  CD2 . PHE A 1 91  ? -6.772  -18.424 9.564   1.00 33.90 ? 313  PHE A CD2 1 
ATOM   613  C  CE1 . PHE A 1 91  ? -4.199  -17.978 8.691   1.00 44.40 ? 313  PHE A CE1 1 
ATOM   614  C  CE2 . PHE A 1 91  ? -6.513  -18.318 8.212   1.00 32.04 ? 313  PHE A CE2 1 
ATOM   615  C  CZ  . PHE A 1 91  ? -5.225  -18.093 7.777   1.00 40.30 ? 313  PHE A CZ  1 
ATOM   616  N  N   . ASN A 1 92  ? -7.992  -16.719 14.352  1.00 24.78 ? 314  ASN A N   1 
ATOM   617  C  CA  . ASN A 1 92  ? -8.483  -16.811 15.711  1.00 25.92 ? 314  ASN A CA  1 
ATOM   618  C  C   . ASN A 1 92  ? -9.444  -17.983 15.860  1.00 23.63 ? 314  ASN A C   1 
ATOM   619  O  O   . ASN A 1 92  ? -10.134 -18.354 14.906  1.00 22.01 ? 314  ASN A O   1 
ATOM   620  C  CB  . ASN A 1 92  ? -9.180  -15.510 16.112  1.00 24.74 ? 314  ASN A CB  1 
ATOM   621  C  CG  . ASN A 1 92  ? -8.195  -14.386 16.321  1.00 39.01 ? 314  ASN A CG  1 
ATOM   622  O  OD1 . ASN A 1 92  ? -7.481  -14.360 17.320  1.00 43.72 ? 314  ASN A OD1 1 
ATOM   623  N  ND2 . ASN A 1 92  ? -8.127  -13.470 15.368  1.00 46.34 ? 314  ASN A ND2 1 
ATOM   624  N  N   . PRO A 1 93  ? -9.486  -18.591 17.046  1.00 25.18 ? 315  PRO A N   1 
ATOM   625  C  CA  . PRO A 1 93  ? -10.382 -19.731 17.250  1.00 23.32 ? 315  PRO A CA  1 
ATOM   626  C  C   . PRO A 1 93  ? -11.836 -19.296 17.259  1.00 22.84 ? 315  PRO A C   1 
ATOM   627  O  O   . PRO A 1 93  ? -12.184 -18.221 17.756  1.00 22.92 ? 315  PRO A O   1 
ATOM   628  C  CB  . PRO A 1 93  ? -9.948  -20.288 18.612  1.00 23.20 ? 315  PRO A CB  1 
ATOM   629  C  CG  . PRO A 1 93  ? -9.309  -19.133 19.300  1.00 32.40 ? 315  PRO A CG  1 
ATOM   630  C  CD  . PRO A 1 93  ? -8.630  -18.346 18.221  1.00 31.29 ? 315  PRO A CD  1 
ATOM   631  N  N   . VAL A 1 94  ? -12.679 -20.137 16.677  1.00 18.21 ? 316  VAL A N   1 
ATOM   632  C  CA  . VAL A 1 94  ? -14.128 -19.985 16.701  1.00 20.36 ? 316  VAL A CA  1 
ATOM   633  C  C   . VAL A 1 94  ? -14.645 -21.163 17.513  1.00 20.12 ? 316  VAL A C   1 
ATOM   634  O  O   . VAL A 1 94  ? -14.657 -22.297 17.020  1.00 19.99 ? 316  VAL A O   1 
ATOM   635  C  CB  . VAL A 1 94  ? -14.735 -19.973 15.292  1.00 21.12 ? 316  VAL A CB  1 
ATOM   636  C  CG1 . VAL A 1 94  ? -16.246 -19.873 15.371  1.00 22.27 ? 316  VAL A CG1 1 
ATOM   637  C  CG2 . VAL A 1 94  ? -14.152 -18.846 14.441  1.00 18.18 ? 316  VAL A CG2 1 
ATOM   638  N  N   . TRP A 1 95  ? -15.053 -20.911 18.758  1.00 18.20 ? 317  TRP A N   1 
ATOM   639  C  CA  . TRP A 1 95  ? -15.393 -21.988 19.675  1.00 16.94 ? 317  TRP A CA  1 
ATOM   640  C  C   . TRP A 1 95  ? -16.812 -22.490 19.456  1.00 17.27 ? 317  TRP A C   1 
ATOM   641  O  O   . TRP A 1 95  ? -17.745 -21.715 19.225  1.00 17.22 ? 317  TRP A O   1 
ATOM   642  C  CB  . TRP A 1 95  ? -15.210 -21.537 21.125  1.00 20.69 ? 317  TRP A CB  1 
ATOM   643  C  CG  . TRP A 1 95  ? -13.784 -21.669 21.576  1.00 19.68 ? 317  TRP A CG  1 
ATOM   644  C  CD1 . TRP A 1 95  ? -12.842 -20.684 21.631  1.00 23.08 ? 317  TRP A CD1 1 
ATOM   645  C  CD2 . TRP A 1 95  ? -13.132 -22.874 21.998  1.00 17.74 ? 317  TRP A CD2 1 
ATOM   646  N  NE1 . TRP A 1 95  ? -11.647 -21.199 22.076  1.00 23.34 ? 317  TRP A NE1 1 
ATOM   647  C  CE2 . TRP A 1 95  ? -11.800 -22.539 22.313  1.00 26.10 ? 317  TRP A CE2 1 
ATOM   648  C  CE3 . TRP A 1 95  ? -13.550 -24.201 22.150  1.00 21.21 ? 317  TRP A CE3 1 
ATOM   649  C  CZ2 . TRP A 1 95  ? -10.879 -23.483 22.767  1.00 25.04 ? 317  TRP A CZ2 1 
ATOM   650  C  CZ3 . TRP A 1 95  ? -12.640 -25.136 22.604  1.00 21.70 ? 317  TRP A CZ3 1 
ATOM   651  C  CH2 . TRP A 1 95  ? -11.318 -24.773 22.910  1.00 20.49 ? 317  TRP A CH2 1 
ATOM   652  N  N   . MET A 1 96  ? -16.971 -23.806 19.557  1.00 16.33 ? 318  MET A N   1 
ATOM   653  C  CA  . MET A 1 96  ? -18.232 -24.472 19.278  1.00 14.80 ? 318  MET A CA  1 
ATOM   654  C  C   . MET A 1 96  ? -18.624 -25.323 20.471  1.00 17.12 ? 318  MET A C   1 
ATOM   655  O  O   . MET A 1 96  ? -17.829 -26.134 20.954  1.00 19.45 ? 318  MET A O   1 
ATOM   656  C  CB  . MET A 1 96  ? -18.117 -25.338 18.012  1.00 19.09 ? 318  MET A CB  1 
ATOM   657  C  CG  . MET A 1 96  ? -17.692 -24.523 16.788  1.00 19.15 ? 318  MET A CG  1 
ATOM   658  S  SD  . MET A 1 96  ? -17.284 -25.533 15.340  1.00 23.53 ? 318  MET A SD  1 
ATOM   659  C  CE  . MET A 1 96  ? -18.713 -26.605 15.333  1.00 16.72 ? 318  MET A CE  1 
ATOM   660  N  N   . ASP A 1 97  ? -19.841 -25.113 20.953  1.00 19.36 ? 319  ASP A N   1 
ATOM   661  C  CA  . ASP A 1 97  ? -20.469 -25.997 21.926  1.00 18.38 ? 319  ASP A CA  1 
ATOM   662  C  C   . ASP A 1 97  ? -21.096 -27.124 21.111  1.00 18.62 ? 319  ASP A C   1 
ATOM   663  O  O   . ASP A 1 97  ? -22.113 -26.929 20.449  1.00 17.55 ? 319  ASP A O   1 
ATOM   664  C  CB  . ASP A 1 97  ? -21.496 -25.216 22.736  1.00 20.40 ? 319  ASP A CB  1 
ATOM   665  C  CG  . ASP A 1 97  ? -21.989 -25.963 23.944  1.00 33.03 ? 319  ASP A CG  1 
ATOM   666  O  OD1 . ASP A 1 97  ? -21.696 -27.170 24.069  1.00 29.48 ? 319  ASP A OD1 1 
ATOM   667  O  OD2 . ASP A 1 97  ? -22.679 -25.326 24.775  1.00 34.04 ? 319  ASP A OD2 1 
ATOM   668  N  N   . LEU A 1 98  ? -20.460 -28.294 21.121  1.00 16.72 ? 320  LEU A N   1 
ATOM   669  C  CA  . LEU A 1 98  ? -20.725 -29.303 20.098  1.00 18.38 ? 320  LEU A CA  1 
ATOM   670  C  C   . LEU A 1 98  ? -22.110 -29.925 20.229  1.00 18.65 ? 320  LEU A C   1 
ATOM   671  O  O   . LEU A 1 98  ? -22.603 -30.172 21.332  1.00 16.75 ? 320  LEU A O   1 
ATOM   672  C  CB  . LEU A 1 98  ? -19.670 -30.407 20.166  1.00 15.23 ? 320  LEU A CB  1 
ATOM   673  C  CG  . LEU A 1 98  ? -18.250 -29.978 19.810  1.00 15.77 ? 320  LEU A CG  1 
ATOM   674  C  CD1 . LEU A 1 98  ? -17.302 -31.151 20.012  1.00 18.41 ? 320  LEU A CD1 1 
ATOM   675  C  CD2 . LEU A 1 98  ? -18.180 -29.468 18.364  1.00 19.16 ? 320  LEU A CD2 1 
ATOM   676  N  N   . THR A 1 99  ? -22.726 -30.194 19.077  1.00 13.97 ? 321  THR A N   1 
ATOM   677  C  CA  . THR A 1 99  ? -23.914 -31.024 18.945  1.00 14.73 ? 321  THR A CA  1 
ATOM   678  C  C   . THR A 1 99  ? -23.574 -32.163 17.992  1.00 12.73 ? 321  THR A C   1 
ATOM   679  O  O   . THR A 1 99  ? -22.496 -32.179 17.395  1.00 14.01 ? 321  THR A O   1 
ATOM   680  C  CB  . THR A 1 99  ? -25.108 -30.220 18.401  1.00 15.18 ? 321  THR A CB  1 
ATOM   681  O  OG1 . THR A 1 99  ? -24.772 -29.681 17.111  1.00 16.30 ? 321  THR A OG1 1 
ATOM   682  C  CG2 . THR A 1 99  ? -25.456 -29.061 19.328  1.00 16.31 ? 321  THR A CG2 1 
ATOM   683  N  N   . GLU A 1 100 ? -24.491 -33.119 17.841  1.00 14.68 ? 322  GLU A N   1 
ATOM   684  C  CA  . GLU A 1 100 ? -24.401 -33.980 16.670  1.00 14.93 ? 322  GLU A CA  1 
ATOM   685  C  C   . GLU A 1 100 ? -24.595 -33.130 15.418  1.00 15.22 ? 322  GLU A C   1 
ATOM   686  O  O   . GLU A 1 100 ? -25.125 -32.012 15.473  1.00 15.12 ? 322  GLU A O   1 
ATOM   687  C  CB  . GLU A 1 100 ? -25.445 -35.100 16.721  1.00 15.94 ? 322  GLU A CB  1 
ATOM   688  C  CG  . GLU A 1 100 ? -25.321 -36.028 17.926  1.00 15.17 ? 322  GLU A CG  1 
ATOM   689  C  CD  . GLU A 1 100 ? -24.119 -36.965 17.866  1.00 18.53 ? 322  GLU A CD  1 
ATOM   690  O  OE1 . GLU A 1 100 ? -23.416 -37.004 16.833  1.00 17.78 ? 322  GLU A OE1 1 
ATOM   691  O  OE2 . GLU A 1 100 ? -23.884 -37.664 18.871  1.00 16.86 ? 322  GLU A OE2 1 
ATOM   692  N  N   . ASN A 1 101 ? -24.161 -33.661 14.271  1.00 11.57 ? 323  ASN A N   1 
ATOM   693  C  CA  . ASN A 1 101 ? -24.309 -32.897 13.037  1.00 13.81 ? 323  ASN A CA  1 
ATOM   694  C  C   . ASN A 1 101 ? -25.765 -32.744 12.622  1.00 15.24 ? 323  ASN A C   1 
ATOM   695  O  O   . ASN A 1 101 ? -26.064 -31.894 11.780  1.00 15.86 ? 323  ASN A O   1 
ATOM   696  C  CB  . ASN A 1 101 ? -23.508 -33.543 11.897  1.00 12.19 ? 323  ASN A CB  1 
ATOM   697  C  CG  . ASN A 1 101 ? -22.011 -33.404 12.100  1.00 15.89 ? 323  ASN A CG  1 
ATOM   698  O  OD1 . ASN A 1 101 ? -21.545 -32.386 12.609  1.00 14.93 ? 323  ASN A OD1 1 
ATOM   699  N  ND2 . ASN A 1 101 ? -21.250 -34.427 11.718  1.00 12.55 ? 323  ASN A ND2 1 
ATOM   700  N  N   . ASN A 1 102 ? -26.667 -33.562 13.159  1.00 14.82 ? 324  ASN A N   1 
ATOM   701  C  CA  . ASN A 1 102 ? -28.094 -33.380 12.911  1.00 18.25 ? 324  ASN A CA  1 
ATOM   702  C  C   . ASN A 1 102 ? -28.732 -32.458 13.940  1.00 17.97 ? 324  ASN A C   1 
ATOM   703  O  O   . ASN A 1 102 ? -29.969 -32.390 14.024  1.00 17.87 ? 324  ASN A O   1 
ATOM   704  C  CB  . ASN A 1 102 ? -28.815 -34.738 12.878  1.00 18.25 ? 324  ASN A CB  1 
ATOM   705  C  CG  . ASN A 1 102 ? -28.864 -35.413 14.238  1.00 21.17 ? 324  ASN A CG  1 
ATOM   706  O  OD1 . ASN A 1 102 ? -28.362 -34.881 15.226  1.00 17.80 ? 324  ASN A OD1 1 
ATOM   707  N  ND2 . ASN A 1 102 ? -29.474 -36.590 14.294  1.00 21.62 ? 324  ASN A ND2 1 
ATOM   708  N  N   . TRP A 1 103 ? -27.905 -31.787 14.745  1.00 16.96 ? 325  TRP A N   1 
ATOM   709  C  CA  . TRP A 1 103 ? -28.231 -30.726 15.692  1.00 18.14 ? 325  TRP A CA  1 
ATOM   710  C  C   . TRP A 1 103 ? -28.860 -31.267 16.972  1.00 21.39 ? 325  TRP A C   1 
ATOM   711  O  O   . TRP A 1 103 ? -29.202 -30.469 17.847  1.00 25.26 ? 325  TRP A O   1 
ATOM   712  C  CB  . TRP A 1 103 ? -29.129 -29.653 15.050  1.00 21.11 ? 325  TRP A CB  1 
ATOM   713  C  CG  . TRP A 1 103 ? -28.498 -29.173 13.774  1.00 18.77 ? 325  TRP A CG  1 
ATOM   714  C  CD1 . TRP A 1 103 ? -28.863 -29.504 12.501  1.00 21.60 ? 325  TRP A CD1 1 
ATOM   715  C  CD2 . TRP A 1 103 ? -27.339 -28.337 13.656  1.00 17.89 ? 325  TRP A CD2 1 
ATOM   716  N  NE1 . TRP A 1 103 ? -28.020 -28.905 11.596  1.00 18.96 ? 325  TRP A NE1 1 
ATOM   717  C  CE2 . TRP A 1 103 ? -27.075 -28.184 12.280  1.00 17.49 ? 325  TRP A CE2 1 
ATOM   718  C  CE3 . TRP A 1 103 ? -26.508 -27.696 14.576  1.00 18.37 ? 325  TRP A CE3 1 
ATOM   719  C  CZ2 . TRP A 1 103 ? -26.018 -27.416 11.806  1.00 16.15 ? 325  TRP A CZ2 1 
ATOM   720  C  CZ3 . TRP A 1 103 ? -25.458 -26.936 14.103  1.00 16.41 ? 325  TRP A CZ3 1 
ATOM   721  C  CH2 . TRP A 1 103 ? -25.225 -26.797 12.729  1.00 16.87 ? 325  TRP A CH2 1 
ATOM   722  N  N   . THR A 1 104 ? -28.992 -32.584 17.129  1.00 17.77 ? 326  THR A N   1 
ATOM   723  C  CA  . THR A 1 104 ? -29.402 -33.141 18.408  1.00 21.10 ? 326  THR A CA  1 
ATOM   724  C  C   . THR A 1 104 ? -28.246 -33.052 19.407  1.00 22.72 ? 326  THR A C   1 
ATOM   725  O  O   . THR A 1 104 ? -27.098 -32.780 19.055  1.00 16.30 ? 326  THR A O   1 
ATOM   726  C  CB  . THR A 1 104 ? -29.880 -34.585 18.242  1.00 19.39 ? 326  THR A CB  1 
ATOM   727  O  OG1 . THR A 1 104 ? -28.818 -35.395 17.726  1.00 18.17 ? 326  THR A OG1 1 
ATOM   728  C  CG2 . THR A 1 104 ? -31.075 -34.655 17.294  1.00 21.33 ? 326  THR A CG2 1 
ATOM   729  N  N   . GLU A 1 105 ? -28.548 -33.276 20.677  1.00 19.55 ? 327  GLU A N   1 
ATOM   730  C  CA  A GLU A 1 105 ? -27.577 -33.069 21.746  0.52 21.50 ? 327  GLU A CA  1 
ATOM   731  C  CA  B GLU A 1 105 ? -27.518 -33.006 21.660  0.48 21.40 ? 327  GLU A CA  1 
ATOM   732  C  C   . GLU A 1 105 ? -26.488 -34.134 21.713  1.00 18.85 ? 327  GLU A C   1 
ATOM   733  O  O   . GLU A 1 105 ? -26.768 -35.301 21.432  1.00 18.32 ? 327  GLU A O   1 
ATOM   734  C  CB  A GLU A 1 105 ? -28.289 -33.103 23.101  0.52 26.40 ? 327  GLU A CB  1 
ATOM   735  C  CB  B GLU A 1 105 ? -28.139 -32.741 23.031  0.48 28.11 ? 327  GLU A CB  1 
ATOM   736  C  CG  A GLU A 1 105 ? -27.372 -33.301 24.297  0.52 25.27 ? 327  GLU A CG  1 
ATOM   737  C  CG  B GLU A 1 105 ? -28.915 -31.411 23.080  0.48 22.19 ? 327  GLU A CG  1 
ATOM   738  C  CD  A GLU A 1 105 ? -28.120 -33.737 25.541  0.52 37.86 ? 327  GLU A CD  1 
ATOM   739  C  CD  B GLU A 1 105 ? -28.074 -30.187 22.675  0.48 22.50 ? 327  GLU A CD  1 
ATOM   740  O  OE1 A GLU A 1 105 ? -29.347 -33.509 25.606  0.52 40.92 ? 327  GLU A OE1 1 
ATOM   741  O  OE1 B GLU A 1 105 ? -26.979 -29.986 23.237  0.48 30.03 ? 327  GLU A OE1 1 
ATOM   742  O  OE2 A GLU A 1 105 ? -27.481 -34.314 26.448  0.52 34.04 ? 327  GLU A OE2 1 
ATOM   743  O  OE2 B GLU A 1 105 ? -28.510 -29.422 21.791  0.48 28.19 ? 327  GLU A OE2 1 
ATOM   744  N  N   . PHE A 1 106 ? -25.250 -33.732 22.014  1.00 14.37 ? 328  PHE A N   1 
ATOM   745  C  CA  . PHE A 1 106 ? -24.125 -34.632 22.252  1.00 15.44 ? 328  PHE A CA  1 
ATOM   746  C  C   . PHE A 1 106 ? -23.780 -34.569 23.735  1.00 17.58 ? 328  PHE A C   1 
ATOM   747  O  O   . PHE A 1 106 ? -23.467 -33.494 24.246  1.00 18.38 ? 328  PHE A O   1 
ATOM   748  C  CB  . PHE A 1 106 ? -22.893 -34.236 21.432  1.00 15.86 ? 328  PHE A CB  1 
ATOM   749  C  CG  . PHE A 1 106 ? -21.655 -35.014 21.793  1.00 17.73 ? 328  PHE A CG  1 
ATOM   750  C  CD1 . PHE A 1 106 ? -21.541 -36.358 21.449  1.00 15.16 ? 328  PHE A CD1 1 
ATOM   751  C  CD2 . PHE A 1 106 ? -20.604 -34.407 22.472  1.00 17.68 ? 328  PHE A CD2 1 
ATOM   752  C  CE1 . PHE A 1 106 ? -20.408 -37.085 21.779  1.00 16.42 ? 328  PHE A CE1 1 
ATOM   753  C  CE2 . PHE A 1 106 ? -19.463 -35.127 22.805  1.00 12.83 ? 328  PHE A CE2 1 
ATOM   754  C  CZ  . PHE A 1 106 ? -19.363 -36.458 22.468  1.00 17.40 ? 328  PHE A CZ  1 
ATOM   755  N  N   . GLN A 1 107 ? -23.818 -35.710 24.416  1.00 15.45 ? 329  GLN A N   1 
ATOM   756  C  CA  . GLN A 1 107 ? -23.458 -35.745 25.831  1.00 15.81 ? 329  GLN A CA  1 
ATOM   757  C  C   . GLN A 1 107 ? -21.961 -35.979 25.971  1.00 16.09 ? 329  GLN A C   1 
ATOM   758  O  O   . GLN A 1 107 ? -21.481 -37.073 25.631  1.00 19.54 ? 329  GLN A O   1 
ATOM   759  C  CB  . GLN A 1 107 ? -24.231 -36.833 26.556  1.00 17.23 ? 329  GLN A CB  1 
ATOM   760  C  CG  . GLN A 1 107 ? -23.871 -36.933 28.031  1.00 21.86 ? 329  GLN A CG  1 
ATOM   761  C  CD  . GLN A 1 107 ? -24.654 -38.012 28.751  1.00 21.51 ? 329  GLN A CD  1 
ATOM   762  O  OE1 . GLN A 1 107 ? -25.729 -38.417 28.306  1.00 26.74 ? 329  GLN A OE1 1 
ATOM   763  N  NE2 . GLN A 1 107 ? -24.110 -38.497 29.860  1.00 21.29 ? 329  GLN A NE2 1 
ATOM   764  N  N   . PRO A 1 108 ? -21.197 -35.024 26.487  1.00 16.17 ? 330  PRO A N   1 
ATOM   765  C  CA  . PRO A 1 108 ? -19.755 -35.224 26.648  1.00 17.23 ? 330  PRO A CA  1 
ATOM   766  C  C   . PRO A 1 108 ? -19.451 -36.119 27.845  1.00 22.85 ? 330  PRO A C   1 
ATOM   767  O  O   . PRO A 1 108 ? -20.310 -36.411 28.679  1.00 19.10 ? 330  PRO A O   1 
ATOM   768  C  CB  . PRO A 1 108 ? -19.232 -33.805 26.870  1.00 18.04 ? 330  PRO A CB  1 
ATOM   769  C  CG  . PRO A 1 108 ? -20.376 -33.114 27.578  1.00 20.47 ? 330  PRO A CG  1 
ATOM   770  C  CD  . PRO A 1 108 ? -21.645 -33.721 27.018  1.00 18.71 ? 330  PRO A CD  1 
ATOM   771  N  N   . PHE A 1 109 ? -18.200 -36.576 27.896  1.00 17.84 ? 331  PHE A N   1 
ATOM   772  C  CA  . PHE A 1 109 ? -17.696 -37.382 29.010  1.00 17.85 ? 331  PHE A CA  1 
ATOM   773  C  C   . PHE A 1 109 ? -18.491 -38.674 29.191  1.00 20.74 ? 331  PHE A C   1 
ATOM   774  O  O   . PHE A 1 109 ? -18.554 -39.222 30.293  1.00 22.42 ? 331  PHE A O   1 
ATOM   775  C  CB  . PHE A 1 109 ? -17.690 -36.563 30.309  1.00 16.89 ? 331  PHE A CB  1 
ATOM   776  C  CG  . PHE A 1 109 ? -16.883 -35.297 30.218  1.00 19.05 ? 331  PHE A CG  1 
ATOM   777  C  CD1 . PHE A 1 109 ? -15.499 -35.344 30.174  1.00 19.63 ? 331  PHE A CD1 1 
ATOM   778  C  CD2 . PHE A 1 109 ? -17.504 -34.068 30.177  1.00 15.75 ? 331  PHE A CD2 1 
ATOM   779  C  CE1 . PHE A 1 109 ? -14.753 -34.184 30.085  1.00 22.90 ? 331  PHE A CE1 1 
ATOM   780  C  CE2 . PHE A 1 109 ? -16.765 -32.900 30.101  1.00 24.91 ? 331  PHE A CE2 1 
ATOM   781  C  CZ  . PHE A 1 109 ? -15.386 -32.960 30.053  1.00 23.77 ? 331  PHE A CZ  1 
ATOM   782  N  N   . ASN A 1 110 ? -19.118 -39.180 28.121  1.00 18.18 ? 332  ASN A N   1 
ATOM   783  C  CA  . ASN A 1 110 ? -19.959 -40.362 28.270  1.00 18.20 ? 332  ASN A CA  1 
ATOM   784  C  C   . ASN A 1 110 ? -19.396 -41.544 27.487  1.00 23.24 ? 332  ASN A C   1 
ATOM   785  O  O   . ASN A 1 110 ? -18.193 -41.821 27.563  1.00 19.48 ? 332  ASN A O   1 
ATOM   786  C  CB  . ASN A 1 110 ? -21.403 -40.060 27.853  1.00 18.74 ? 332  ASN A CB  1 
ATOM   787  C  CG  . ASN A 1 110 ? -22.415 -41.048 28.454  1.00 31.27 ? 332  ASN A CG  1 
ATOM   788  O  OD1 . ASN A 1 110 ? -22.190 -41.622 29.524  1.00 27.78 ? 332  ASN A OD1 1 
ATOM   789  N  ND2 . ASN A 1 110 ? -23.527 -41.256 27.753  1.00 29.92 ? 332  ASN A ND2 1 
ATOM   790  N  N   . ASP A 1 111 ? -20.246 -42.234 26.723  1.00 18.96 ? 333  ASP A N   1 
ATOM   791  C  CA  A ASP A 1 111 ? -19.869 -43.492 26.089  0.59 21.02 ? 333  ASP A CA  1 
ATOM   792  C  CA  B ASP A 1 111 ? -19.896 -43.497 26.085  0.41 21.06 ? 333  ASP A CA  1 
ATOM   793  C  C   . ASP A 1 111 ? -19.689 -43.359 24.578  1.00 23.90 ? 333  ASP A C   1 
ATOM   794  O  O   . ASP A 1 111 ? -19.827 -44.342 23.846  1.00 20.52 ? 333  ASP A O   1 
ATOM   795  C  CB  A ASP A 1 111 ? -20.892 -44.581 26.404  0.59 23.46 ? 333  ASP A CB  1 
ATOM   796  C  CB  B ASP A 1 111 ? -20.977 -44.538 26.372  0.41 23.47 ? 333  ASP A CB  1 
ATOM   797  C  CG  A ASP A 1 111 ? -22.256 -44.308 25.798  0.59 24.78 ? 333  ASP A CG  1 
ATOM   798  C  CG  B ASP A 1 111 ? -20.454 -45.956 26.306  0.41 27.11 ? 333  ASP A CG  1 
ATOM   799  O  OD1 A ASP A 1 111 ? -22.468 -43.212 25.235  0.59 27.92 ? 333  ASP A OD1 1 
ATOM   800  O  OD1 B ASP A 1 111 ? -19.220 -46.140 26.363  0.41 33.37 ? 333  ASP A OD1 1 
ATOM   801  O  OD2 A ASP A 1 111 ? -23.126 -45.204 25.887  0.59 34.41 ? 333  ASP A OD2 1 
ATOM   802  O  OD2 B ASP A 1 111 ? -21.277 -46.889 26.197  0.41 34.74 ? 333  ASP A OD2 1 
ATOM   803  N  N   . GLN A 1 112 ? -19.368 -42.158 24.101  1.00 18.98 ? 334  GLN A N   1 
ATOM   804  C  CA  . GLN A 1 112 ? -19.165 -41.912 22.676  1.00 14.50 ? 334  GLN A CA  1 
ATOM   805  C  C   . GLN A 1 112 ? -17.985 -40.950 22.574  1.00 15.59 ? 334  GLN A C   1 
ATOM   806  O  O   . GLN A 1 112 ? -17.979 -39.913 23.260  1.00 18.24 ? 334  GLN A O   1 
ATOM   807  C  CB  . GLN A 1 112 ? -20.422 -41.322 22.032  1.00 15.50 ? 334  GLN A CB  1 
ATOM   808  C  CG  . GLN A 1 112 ? -20.372 -41.200 20.495  1.00 15.06 ? 334  GLN A CG  1 
ATOM   809  C  CD  . GLN A 1 112 ? -21.689 -40.686 19.944  1.00 14.46 ? 334  GLN A CD  1 
ATOM   810  O  OE1 . GLN A 1 112 ? -22.733 -41.310 20.137  1.00 19.71 ? 334  GLN A OE1 1 
ATOM   811  N  NE2 . GLN A 1 112 ? -21.657 -39.527 19.292  1.00 13.85 ? 334  GLN A NE2 1 
ATOM   812  N  N   . PRO A 1 113 ? -16.982 -41.254 21.737  1.00 15.59 ? 335  PRO A N   1 
ATOM   813  C  CA  . PRO A 1 113 ? -15.728 -40.476 21.772  1.00 13.16 ? 335  PRO A CA  1 
ATOM   814  C  C   . PRO A 1 113 ? -15.859 -39.050 21.283  1.00 15.59 ? 335  PRO A C   1 
ATOM   815  O  O   . PRO A 1 113 ? -15.067 -38.191 21.694  1.00 15.18 ? 335  PRO A O   1 
ATOM   816  C  CB  . PRO A 1 113 ? -14.788 -41.270 20.847  1.00 17.15 ? 335  PRO A CB  1 
ATOM   817  C  CG  . PRO A 1 113 ? -15.436 -42.586 20.634  1.00 17.41 ? 335  PRO A CG  1 
ATOM   818  C  CD  . PRO A 1 113 ? -16.908 -42.397 20.814  1.00 17.77 ? 335  PRO A CD  1 
ATOM   819  N  N   . ALA A 1 114 ? -16.794 -38.787 20.379  1.00 14.92 ? 336  ALA A N   1 
ATOM   820  C  CA  . ALA A 1 114 ? -16.991 -37.491 19.751  1.00 17.35 ? 336  ALA A CA  1 
ATOM   821  C  C   . ALA A 1 114 ? -18.336 -37.583 19.050  1.00 14.07 ? 336  ALA A C   1 
ATOM   822  O  O   . ALA A 1 114 ? -18.880 -38.689 18.937  1.00 14.67 ? 336  ALA A O   1 
ATOM   823  C  CB  . ALA A 1 114 ? -15.859 -37.174 18.763  1.00 17.03 ? 336  ALA A CB  1 
ATOM   824  N  N   . PRO A 1 115 ? -18.917 -36.469 18.599  1.00 12.67 ? 337  PRO A N   1 
ATOM   825  C  CA  . PRO A 1 115 ? -20.141 -36.559 17.792  1.00 12.55 ? 337  PRO A CA  1 
ATOM   826  C  C   . PRO A 1 115 ? -19.918 -37.445 16.574  1.00 14.26 ? 337  PRO A C   1 
ATOM   827  O  O   . PRO A 1 115 ? -18.797 -37.586 16.079  1.00 13.64 ? 337  PRO A O   1 
ATOM   828  C  CB  . PRO A 1 115 ? -20.407 -35.107 17.379  1.00 11.78 ? 337  PRO A CB  1 
ATOM   829  C  CG  . PRO A 1 115 ? -19.731 -34.278 18.481  1.00 13.89 ? 337  PRO A CG  1 
ATOM   830  C  CD  . PRO A 1 115 ? -18.495 -35.072 18.825  1.00 14.52 ? 337  PRO A CD  1 
ATOM   831  N  N   . LEU A 1 116 ? -21.002 -38.041 16.088  1.00 11.96 ? 338  LEU A N   1 
ATOM   832  C  CA  . LEU A 1 116 ? -20.865 -38.951 14.961  1.00 12.07 ? 338  LEU A CA  1 
ATOM   833  C  C   . LEU A 1 116 ? -20.360 -38.188 13.747  1.00 11.09 ? 338  LEU A C   1 
ATOM   834  O  O   . LEU A 1 116 ? -20.712 -37.024 13.535  1.00 14.36 ? 338  LEU A O   1 
ATOM   835  C  CB  . LEU A 1 116 ? -22.200 -39.628 14.646  1.00 12.16 ? 338  LEU A CB  1 
ATOM   836  C  CG  . LEU A 1 116 ? -22.866 -40.420 15.785  1.00 11.93 ? 338  LEU A CG  1 
ATOM   837  C  CD1 . LEU A 1 116 ? -24.091 -41.167 15.252  1.00 14.61 ? 338  LEU A CD1 1 
ATOM   838  C  CD2 . LEU A 1 116 ? -21.891 -41.400 16.437  1.00 11.46 ? 338  LEU A CD2 1 
ATOM   839  N  N   . GLY A 1 117 ? -19.510 -38.842 12.954  1.00 11.54 ? 339  GLY A N   1 
ATOM   840  C  CA  . GLY A 1 117 ? -18.953 -38.209 11.780  1.00 10.75 ? 339  GLY A CA  1 
ATOM   841  C  C   . GLY A 1 117 ? -17.744 -37.338 12.033  1.00 12.21 ? 339  GLY A C   1 
ATOM   842  O  O   . GLY A 1 117 ? -17.085 -36.926 11.070  1.00 13.37 ? 339  GLY A O   1 
ATOM   843  N  N   . CYS A 1 118 ? -17.427 -37.047 13.289  1.00 10.63 ? 340  CYS A N   1 
ATOM   844  C  CA  . CYS A 1 118 ? -16.238 -36.268 13.609  1.00 12.71 ? 340  CYS A CA  1 
ATOM   845  C  C   . CYS A 1 118 ? -15.008 -36.900 12.953  1.00 11.63 ? 340  CYS A C   1 
ATOM   846  O  O   . CYS A 1 118 ? -14.887 -38.128 12.937  1.00 12.50 ? 340  CYS A O   1 
ATOM   847  C  CB  . CYS A 1 118 ? -16.061 -36.216 15.131  1.00 13.59 ? 340  CYS A CB  1 
ATOM   848  S  SG  . CYS A 1 118 ? -14.617 -35.307 15.708  1.00 15.03 ? 340  CYS A SG  1 
ATOM   849  N  N   . PRO A 1 119 ? -14.092 -36.106 12.389  1.00 12.40 ? 341  PRO A N   1 
ATOM   850  C  CA  . PRO A 1 119 ? -12.862 -36.682 11.824  1.00 11.25 ? 341  PRO A CA  1 
ATOM   851  C  C   . PRO A 1 119 ? -12.158 -37.615 12.805  1.00 13.12 ? 341  PRO A C   1 
ATOM   852  O  O   . PRO A 1 119 ? -12.094 -37.351 14.010  1.00 14.26 ? 341  PRO A O   1 
ATOM   853  C  CB  . PRO A 1 119 ? -12.008 -35.447 11.513  1.00 13.45 ? 341  PRO A CB  1 
ATOM   854  C  CG  . PRO A 1 119 ? -13.031 -34.357 11.228  1.00 13.10 ? 341  PRO A CG  1 
ATOM   855  C  CD  . PRO A 1 119 ? -14.190 -34.651 12.152  1.00 12.99 ? 341  PRO A CD  1 
ATOM   856  N  N   . ASP A 1 120 ? -11.621 -38.721 12.283  1.00 12.14 ? 342  ASP A N   1 
ATOM   857  C  CA  . ASP A 1 120 ? -10.891 -39.688 13.096  1.00 13.30 ? 342  ASP A CA  1 
ATOM   858  C  C   . ASP A 1 120 ? -9.433  -39.775 12.656  1.00 13.54 ? 342  ASP A C   1 
ATOM   859  O  O   . ASP A 1 120 ? -8.810  -40.835 12.694  1.00 14.45 ? 342  ASP A O   1 
ATOM   860  C  CB  . ASP A 1 120 ? -11.571 -41.064 13.082  1.00 12.86 ? 342  ASP A CB  1 
ATOM   861  C  CG  . ASP A 1 120 ? -11.532 -41.751 11.724  1.00 14.41 ? 342  ASP A CG  1 
ATOM   862  O  OD1 . ASP A 1 120 ? -11.136 -41.127 10.720  1.00 15.35 ? 342  ASP A OD1 1 
ATOM   863  O  OD2 . ASP A 1 120 ? -11.927 -42.938 11.665  1.00 13.91 ? 342  ASP A OD2 1 
ATOM   864  N  N   . PHE A 1 121 ? -8.873  -38.639 12.245  1.00 13.18 ? 343  PHE A N   1 
ATOM   865  C  CA  . PHE A 1 121 ? -7.464  -38.540 11.900  1.00 13.11 ? 343  PHE A CA  1 
ATOM   866  C  C   . PHE A 1 121 ? -6.944  -37.184 12.360  1.00 18.03 ? 343  PHE A C   1 
ATOM   867  O  O   . PHE A 1 121 ? -7.718  -36.273 12.689  1.00 16.25 ? 343  PHE A O   1 
ATOM   868  C  CB  . PHE A 1 121 ? -7.242  -38.756 10.392  1.00 13.48 ? 343  PHE A CB  1 
ATOM   869  C  CG  . PHE A 1 121 ? -8.067  -37.851 9.518   1.00 15.60 ? 343  PHE A CG  1 
ATOM   870  C  CD1 . PHE A 1 121 ? -7.616  -36.589 9.187   1.00 14.31 ? 343  PHE A CD1 1 
ATOM   871  C  CD2 . PHE A 1 121 ? -9.295  -38.272 9.023   1.00 14.52 ? 343  PHE A CD2 1 
ATOM   872  C  CE1 . PHE A 1 121 ? -8.369  -35.757 8.381   1.00 15.63 ? 343  PHE A CE1 1 
ATOM   873  C  CE2 . PHE A 1 121 ? -10.063 -37.448 8.218   1.00 14.05 ? 343  PHE A CE2 1 
ATOM   874  C  CZ  . PHE A 1 121 ? -9.597  -36.187 7.896   1.00 16.59 ? 343  PHE A CZ  1 
ATOM   875  N  N   . LYS A 1 122 ? -5.613  -37.062 12.389  1.00 17.05 ? 344  LYS A N   1 
ATOM   876  C  CA  . LYS A 1 122 ? -4.927  -35.869 12.875  1.00 14.50 ? 344  LYS A CA  1 
ATOM   877  C  C   . LYS A 1 122 ? -4.385  -35.080 11.691  1.00 17.58 ? 344  LYS A C   1 
ATOM   878  O  O   . LYS A 1 122 ? -3.444  -35.521 11.028  1.00 19.79 ? 344  LYS A O   1 
ATOM   879  C  CB  . LYS A 1 122 ? -3.794  -36.258 13.823  1.00 15.86 ? 344  LYS A CB  1 
ATOM   880  C  CG  . LYS A 1 122 ? -4.288  -36.810 15.154  1.00 15.81 ? 344  LYS A CG  1 
ATOM   881  C  CD  . LYS A 1 122 ? -3.134  -37.105 16.106  1.00 20.05 ? 344  LYS A CD  1 
ATOM   882  C  CE  . LYS A 1 122 ? -2.288  -38.262 15.602  1.00 27.64 ? 344  LYS A CE  1 
ATOM   883  N  NZ  . LYS A 1 122 ? -1.175  -38.566 16.556  1.00 43.85 ? 344  LYS A NZ  1 
ATOM   884  N  N   . ALA A 1 123 ? -4.953  -33.904 11.441  1.00 15.23 ? 345  ALA A N   1 
ATOM   885  C  CA  . ALA A 1 123 ? -4.472  -33.067 10.353  1.00 15.53 ? 345  ALA A CA  1 
ATOM   886  C  C   . ALA A 1 123 ? -5.011  -31.661 10.533  1.00 13.13 ? 345  ALA A C   1 
ATOM   887  O  O   . ALA A 1 123 ? -5.989  -31.440 11.245  1.00 16.65 ? 345  ALA A O   1 
ATOM   888  C  CB  . ALA A 1 123 ? -4.896  -33.612 8.977   1.00 15.63 ? 345  ALA A CB  1 
ATOM   889  N  N   . LYS A 1 124 ? -4.371  -30.712 9.857   1.00 13.83 ? 346  LYS A N   1 
ATOM   890  C  CA  . LYS A 1 124 ? -4.987  -29.410 9.619   1.00 16.78 ? 346  LYS A CA  1 
ATOM   891  C  C   . LYS A 1 124 ? -5.994  -29.590 8.485   1.00 17.64 ? 346  LYS A C   1 
ATOM   892  O  O   . LYS A 1 124 ? -5.619  -29.690 7.315   1.00 16.10 ? 346  LYS A O   1 
ATOM   893  C  CB  . LYS A 1 124 ? -3.939  -28.358 9.275   1.00 15.80 ? 346  LYS A CB  1 
ATOM   894  C  CG  . LYS A 1 124 ? -4.512  -26.964 9.123   1.00 19.16 ? 346  LYS A CG  1 
ATOM   895  C  CD  . LYS A 1 124 ? -3.403  -25.934 8.947   1.00 23.47 ? 346  LYS A CD  1 
ATOM   896  C  CE  . LYS A 1 124 ? -3.961  -24.554 8.680   1.00 28.08 ? 346  LYS A CE  1 
ATOM   897  N  NZ  . LYS A 1 124 ? -2.853  -23.559 8.551   1.00 38.81 ? 346  LYS A NZ  1 
ATOM   898  N  N   . ILE A 1 125 ? -7.277  -29.656 8.834   1.00 15.31 ? 347  ILE A N   1 
ATOM   899  C  CA  . ILE A 1 125 ? -8.337  -29.936 7.869   1.00 14.40 ? 347  ILE A CA  1 
ATOM   900  C  C   . ILE A 1 125 ? -8.901  -28.613 7.378   1.00 14.36 ? 347  ILE A C   1 
ATOM   901  O  O   . ILE A 1 125 ? -9.434  -27.832 8.172   1.00 15.24 ? 347  ILE A O   1 
ATOM   902  C  CB  . ILE A 1 125 ? -9.448  -30.789 8.498   1.00 13.43 ? 347  ILE A CB  1 
ATOM   903  C  CG1 . ILE A 1 125 ? -8.866  -32.025 9.201   1.00 14.83 ? 347  ILE A CG1 1 
ATOM   904  C  CG2 . ILE A 1 125 ? -10.463 -31.194 7.426   1.00 14.04 ? 347  ILE A CG2 1 
ATOM   905  C  CD1 . ILE A 1 125 ? -9.926  -32.856 9.959   1.00 16.16 ? 347  ILE A CD1 1 
ATOM   906  N  N   . LEU A 1 126 ? -8.803  -28.364 6.075   1.00 12.96 ? 348  LEU A N   1 
ATOM   907  C  CA  . LEU A 1 126 ? -9.307  -27.126 5.499   1.00 12.03 ? 348  LEU A CA  1 
ATOM   908  C  C   . LEU A 1 126 ? -10.775 -27.275 5.145   1.00 13.84 ? 348  LEU A C   1 
ATOM   909  O  O   . LEU A 1 126 ? -11.243 -28.360 4.805   1.00 15.89 ? 348  LEU A O   1 
ATOM   910  C  CB  . LEU A 1 126 ? -8.525  -26.754 4.238   1.00 15.50 ? 348  LEU A CB  1 
ATOM   911  C  CG  . LEU A 1 126 ? -7.020  -26.836 4.449   1.00 19.87 ? 348  LEU A CG  1 
ATOM   912  C  CD1 . LEU A 1 126 ? -6.281  -26.780 3.129   1.00 20.26 ? 348  LEU A CD1 1 
ATOM   913  C  CD2 . LEU A 1 126 ? -6.597  -25.700 5.384   1.00 17.46 ? 348  LEU A CD2 1 
ATOM   914  N  N   . GLY A 1 127 ? -11.500 -26.170 5.209   1.00 15.89 ? 349  GLY A N   1 
ATOM   915  C  CA  . GLY A 1 127 ? -12.898 -26.242 4.840   1.00 16.82 ? 349  GLY A CA  1 
ATOM   916  C  C   . GLY A 1 127 ? -13.599 -24.916 4.978   1.00 17.00 ? 349  GLY A C   1 
ATOM   917  O  O   . GLY A 1 127 ? -12.981 -23.859 4.835   1.00 16.83 ? 349  GLY A O   1 
ATOM   918  N  N   . THR A 1 128 ? -14.897 -24.962 5.249   1.00 13.49 ? 350  THR A N   1 
ATOM   919  C  CA  . THR A 1 128 ? -15.672 -23.759 5.482   1.00 15.54 ? 350  THR A CA  1 
ATOM   920  C  C   . THR A 1 128 ? -16.494 -23.937 6.749   1.00 17.88 ? 350  THR A C   1 
ATOM   921  O  O   . THR A 1 128 ? -16.779 -25.059 7.187   1.00 16.25 ? 350  THR A O   1 
ATOM   922  C  CB  . THR A 1 128 ? -16.604 -23.440 4.310   1.00 16.37 ? 350  THR A CB  1 
ATOM   923  O  OG1 . THR A 1 128 ? -17.476 -24.554 4.097   1.00 16.84 ? 350  THR A OG1 1 
ATOM   924  C  CG2 . THR A 1 128 ? -15.804 -23.140 3.023   1.00 18.02 ? 350  THR A CG2 1 
ATOM   925  N  N   . LEU A 1 129 ? -16.882 -22.806 7.329   1.00 15.37 ? 351  LEU A N   1 
ATOM   926  C  CA  . LEU A 1 129 ? -17.769 -22.770 8.482   1.00 14.85 ? 351  LEU A CA  1 
ATOM   927  C  C   . LEU A 1 129 ? -19.092 -22.184 8.026   1.00 16.17 ? 351  LEU A C   1 
ATOM   928  O  O   . LEU A 1 129 ? -19.115 -21.105 7.424   1.00 15.30 ? 351  LEU A O   1 
ATOM   929  C  CB  . LEU A 1 129 ? -17.170 -21.934 9.620   1.00 13.46 ? 351  LEU A CB  1 
ATOM   930  C  CG  . LEU A 1 129 ? -17.948 -22.040 10.930  1.00 16.09 ? 351  LEU A CG  1 
ATOM   931  C  CD1 . LEU A 1 129 ? -17.795 -23.443 11.529  1.00 16.24 ? 351  LEU A CD1 1 
ATOM   932  C  CD2 . LEU A 1 129 ? -17.508 -20.960 11.926  1.00 20.07 ? 351  LEU A CD2 1 
ATOM   933  N  N   . ILE A 1 130 ? -20.182 -22.901 8.289   1.00 15.01 ? 352  ILE A N   1 
ATOM   934  C  CA  . ILE A 1 130 ? -21.480 -22.611 7.687   1.00 14.86 ? 352  ILE A CA  1 
ATOM   935  C  C   . ILE A 1 130 ? -22.409 -22.089 8.768   1.00 14.09 ? 352  ILE A C   1 
ATOM   936  O  O   . ILE A 1 130 ? -22.741 -22.819 9.708   1.00 14.29 ? 352  ILE A O   1 
ATOM   937  C  CB  . ILE A 1 130 ? -22.086 -23.856 7.023   1.00 13.21 ? 352  ILE A CB  1 
ATOM   938  C  CG1 . ILE A 1 130 ? -21.143 -24.410 5.951   1.00 15.51 ? 352  ILE A CG1 1 
ATOM   939  C  CG2 . ILE A 1 130 ? -23.413 -23.504 6.384   1.00 13.03 ? 352  ILE A CG2 1 
ATOM   940  C  CD1 . ILE A 1 130 ? -21.528 -25.823 5.488   1.00 16.61 ? 352  ILE A CD1 1 
ATOM   941  N  N   . ARG A 1 131 ? -22.824 -20.828 8.633   1.00 16.26 ? 353  ARG A N   1 
ATOM   942  C  CA  . ARG A 1 131 ? -23.874 -20.278 9.478   1.00 16.19 ? 353  ARG A CA  1 
ATOM   943  C  C   . ARG A 1 131 ? -25.219 -20.761 8.958   1.00 16.89 ? 353  ARG A C   1 
ATOM   944  O  O   . ARG A 1 131 ? -25.497 -20.680 7.757   1.00 16.67 ? 353  ARG A O   1 
ATOM   945  C  CB  . ARG A 1 131 ? -23.800 -18.744 9.486   1.00 17.97 ? 353  ARG A CB  1 
ATOM   946  C  CG  . ARG A 1 131 ? -24.797 -18.060 10.423  1.00 18.35 ? 353  ARG A CG  1 
ATOM   947  C  CD  . ARG A 1 131 ? -24.569 -16.546 10.437  1.00 16.03 ? 353  ARG A CD  1 
ATOM   948  N  NE  . ARG A 1 131 ? -24.994 -15.912 9.189   1.00 17.17 ? 353  ARG A NE  1 
ATOM   949  C  CZ  . ARG A 1 131 ? -24.756 -14.643 8.876   1.00 19.80 ? 353  ARG A CZ  1 
ATOM   950  N  NH1 . ARG A 1 131 ? -24.028 -13.861 9.661   1.00 20.67 ? 353  ARG A NH1 1 
ATOM   951  N  NH2 . ARG A 1 131 ? -25.260 -14.147 7.749   1.00 21.82 ? 353  ARG A NH2 1 
ATOM   952  N  N   . GLN A 1 132 ? -26.048 -21.278 9.857   1.00 17.14 ? 354  GLN A N   1 
ATOM   953  C  CA  . GLN A 1 132 ? -27.236 -22.003 9.445   1.00 16.75 ? 354  GLN A CA  1 
ATOM   954  C  C   . GLN A 1 132 ? -28.345 -21.035 9.031   1.00 20.41 ? 354  GLN A C   1 
ATOM   955  O  O   . GLN A 1 132 ? -28.287 -19.840 9.340   1.00 21.03 ? 354  GLN A O   1 
ATOM   956  C  CB  . GLN A 1 132 ? -27.673 -22.941 10.570  1.00 18.52 ? 354  GLN A CB  1 
ATOM   957  C  CG  . GLN A 1 132 ? -26.647 -24.064 10.820  1.00 18.25 ? 354  GLN A CG  1 
ATOM   958  C  CD  . GLN A 1 132 ? -26.373 -24.905 9.564   1.00 19.60 ? 354  GLN A CD  1 
ATOM   959  O  OE1 . GLN A 1 132 ? -25.244 -24.949 9.046   1.00 20.51 ? 354  GLN A OE1 1 
ATOM   960  N  NE2 . GLN A 1 132 ? -27.404 -25.575 9.079   1.00 13.66 ? 354  GLN A NE2 1 
ATOM   961  N  N   . PRO A 1 133 ? -29.341 -21.514 8.276   1.00 18.69 ? 355  PRO A N   1 
ATOM   962  C  CA  . PRO A 1 133 ? -30.312 -20.580 7.672   1.00 21.98 ? 355  PRO A CA  1 
ATOM   963  C  C   . PRO A 1 133 ? -31.092 -19.735 8.671   1.00 24.81 ? 355  PRO A C   1 
ATOM   964  O  O   . PRO A 1 133 ? -31.491 -18.615 8.325   1.00 23.21 ? 355  PRO A O   1 
ATOM   965  C  CB  . PRO A 1 133 ? -31.238 -21.513 6.879   1.00 23.42 ? 355  PRO A CB  1 
ATOM   966  C  CG  . PRO A 1 133 ? -30.364 -22.690 6.543   1.00 21.27 ? 355  PRO A CG  1 
ATOM   967  C  CD  . PRO A 1 133 ? -29.503 -22.887 7.755   1.00 20.34 ? 355  PRO A CD  1 
ATOM   968  N  N   . ASN A 1 134 ? -31.314 -20.206 9.902   1.00 21.40 ? 356  ASN A N   1 
ATOM   969  C  CA  A ASN A 1 134 ? -32.073 -19.414 10.867  0.45 23.70 ? 356  ASN A CA  1 
ATOM   970  C  CA  B ASN A 1 134 ? -32.080 -19.412 10.845  0.32 23.73 ? 356  ASN A CA  1 
ATOM   971  C  CA  C ASN A 1 134 ? -32.069 -19.420 10.876  0.23 23.74 ? 356  ASN A CA  1 
ATOM   972  C  C   . ASN A 1 134 ? -31.374 -18.105 11.201  1.00 24.32 ? 356  ASN A C   1 
ATOM   973  O  O   . ASN A 1 134 ? -32.030 -17.134 11.595  1.00 27.77 ? 356  ASN A O   1 
ATOM   974  C  CB  A ASN A 1 134 ? -32.323 -20.219 12.148  0.45 24.05 ? 356  ASN A CB  1 
ATOM   975  C  CB  B ASN A 1 134 ? -32.366 -20.204 12.112  0.32 24.08 ? 356  ASN A CB  1 
ATOM   976  C  CB  C ASN A 1 134 ? -32.296 -20.221 12.160  0.23 24.10 ? 356  ASN A CB  1 
ATOM   977  C  CG  A ASN A 1 134 ? -31.039 -20.583 12.879  0.45 25.91 ? 356  ASN A CG  1 
ATOM   978  C  CG  B ASN A 1 134 ? -33.634 -19.752 12.771  0.32 25.84 ? 356  ASN A CG  1 
ATOM   979  C  CG  C ASN A 1 134 ? -33.472 -21.165 12.049  0.23 25.56 ? 356  ASN A CG  1 
ATOM   980  O  OD1 A ASN A 1 134 ? -30.090 -21.096 12.286  0.45 24.66 ? 356  ASN A OD1 1 
ATOM   981  O  OD1 B ASN A 1 134 ? -34.490 -19.162 12.111  0.32 26.96 ? 356  ASN A OD1 1 
ATOM   982  O  OD1 C ASN A 1 134 ? -33.910 -21.488 10.948  0.23 31.24 ? 356  ASN A OD1 1 
ATOM   983  N  ND2 A ASN A 1 134 ? -31.012 -20.330 14.183  0.45 27.40 ? 356  ASN A ND2 1 
ATOM   984  N  ND2 B ASN A 1 134 ? -33.768 -20.004 14.067  0.32 31.72 ? 356  ASN A ND2 1 
ATOM   985  N  ND2 C ASN A 1 134 ? -33.990 -21.612 13.188  0.23 22.24 ? 356  ASN A ND2 1 
ATOM   986  N  N   A ASN A 1 135 ? -30.055 -18.045 11.042  0.99 22.63 ? 357  ASN A N   1 
ATOM   987  C  CA  A ASN A 1 135 ? -29.321 -16.809 11.262  0.99 24.59 ? 357  ASN A CA  1 
ATOM   988  C  C   A ASN A 1 135 ? -28.780 -16.224 9.964   0.99 25.65 ? 357  ASN A C   1 
ATOM   989  O  O   A ASN A 1 135 ? -27.806 -15.460 9.983   0.99 25.13 ? 357  ASN A O   1 
ATOM   990  C  CB  A ASN A 1 135 ? -28.207 -17.047 12.275  0.99 24.86 ? 357  ASN A CB  1 
ATOM   991  C  CG  A ASN A 1 135 ? -28.755 -17.312 13.668  0.99 29.55 ? 357  ASN A CG  1 
ATOM   992  O  OD1 A ASN A 1 135 ? -28.481 -18.343 14.265  0.99 32.24 ? 357  ASN A OD1 1 
ATOM   993  N  ND2 A ASN A 1 135 ? -29.558 -16.381 14.176  0.99 31.98 ? 357  ASN A ND2 1 
ATOM   994  N  N   . GLY A 1 136 ? -29.407 -16.553 8.841   1.00 20.14 ? 358  GLY A N   1 
ATOM   995  C  CA  . GLY A 1 136 ? -28.939 -16.099 7.547   1.00 22.75 ? 358  GLY A CA  1 
ATOM   996  C  C   . GLY A 1 136 ? -27.876 -17.021 6.987   1.00 19.89 ? 358  GLY A C   1 
ATOM   997  O  O   . GLY A 1 136 ? -26.783 -17.128 7.551   1.00 18.78 ? 358  GLY A O   1 
ATOM   998  N  N   . SER A 1 137 ? -28.181 -17.716 5.901   1.00 18.62 ? 359  SER A N   1 
ATOM   999  C  CA  A SER A 1 137 ? -27.194 -18.613 5.310   0.84 17.50 ? 359  SER A CA  1 
ATOM   1000 C  CA  B SER A 1 137 ? -27.203 -18.612 5.299   0.16 17.53 ? 359  SER A CA  1 
ATOM   1001 C  C   . SER A 1 137 ? -25.984 -17.823 4.837   1.00 15.60 ? 359  SER A C   1 
ATOM   1002 O  O   . SER A 1 137 ? -26.110 -16.878 4.054   1.00 18.02 ? 359  SER A O   1 
ATOM   1003 C  CB  A SER A 1 137 ? -27.802 -19.395 4.145   0.84 18.03 ? 359  SER A CB  1 
ATOM   1004 C  CB  B SER A 1 137 ? -27.831 -19.363 4.126   0.16 17.98 ? 359  SER A CB  1 
ATOM   1005 O  OG  A SER A 1 137 ? -28.587 -20.474 4.617   0.84 14.67 ? 359  SER A OG  1 
ATOM   1006 O  OG  B SER A 1 137 ? -26.924 -20.306 3.588   0.16 15.94 ? 359  SER A OG  1 
ATOM   1007 N  N   . TYR A 1 138 ? -24.815 -18.215 5.324   1.00 13.93 ? 360  TYR A N   1 
ATOM   1008 C  CA  . TYR A 1 138 ? -23.550 -17.615 4.942   1.00 17.24 ? 360  TYR A CA  1 
ATOM   1009 C  C   . TYR A 1 138 ? -22.477 -18.620 5.306   1.00 16.79 ? 360  TYR A C   1 
ATOM   1010 O  O   . TYR A 1 138 ? -22.671 -19.435 6.208   1.00 17.73 ? 360  TYR A O   1 
ATOM   1011 C  CB  . TYR A 1 138 ? -23.319 -16.278 5.655   1.00 18.22 ? 360  TYR A CB  1 
ATOM   1012 C  CG  . TYR A 1 138 ? -22.024 -15.603 5.294   1.00 16.45 ? 360  TYR A CG  1 
ATOM   1013 C  CD1 . TYR A 1 138 ? -21.774 -15.187 3.992   1.00 19.60 ? 360  TYR A CD1 1 
ATOM   1014 C  CD2 . TYR A 1 138 ? -21.051 -15.374 6.255   1.00 18.53 ? 360  TYR A CD2 1 
ATOM   1015 C  CE1 . TYR A 1 138 ? -20.579 -14.559 3.662   1.00 23.17 ? 360  TYR A CE1 1 
ATOM   1016 C  CE2 . TYR A 1 138 ? -19.855 -14.759 5.933   1.00 23.88 ? 360  TYR A CE2 1 
ATOM   1017 C  CZ  . TYR A 1 138 ? -19.628 -14.347 4.640   1.00 24.52 ? 360  TYR A CZ  1 
ATOM   1018 O  OH  . TYR A 1 138 ? -18.438 -13.729 4.330   1.00 25.77 ? 360  TYR A OH  1 
ATOM   1019 N  N   . TYR A 1 139 ? -21.362 -18.591 4.585   1.00 15.29 ? 361  TYR A N   1 
ATOM   1020 C  CA  . TYR A 1 139 ? -20.247 -19.416 5.017   1.00 16.00 ? 361  TYR A CA  1 
ATOM   1021 C  C   . TYR A 1 139 ? -18.938 -18.749 4.645   1.00 14.70 ? 361  TYR A C   1 
ATOM   1022 O  O   . TYR A 1 139 ? -18.883 -17.889 3.764   1.00 17.22 ? 361  TYR A O   1 
ATOM   1023 C  CB  . TYR A 1 139 ? -20.331 -20.839 4.448   1.00 17.55 ? 361  TYR A CB  1 
ATOM   1024 C  CG  . TYR A 1 139 ? -20.281 -21.034 2.940   1.00 14.65 ? 361  TYR A CG  1 
ATOM   1025 C  CD1 . TYR A 1 139 ? -19.070 -21.148 2.267   1.00 17.57 ? 361  TYR A CD1 1 
ATOM   1026 C  CD2 . TYR A 1 139 ? -21.451 -21.217 2.212   1.00 14.38 ? 361  TYR A CD2 1 
ATOM   1027 C  CE1 . TYR A 1 139 ? -19.029 -21.398 0.891   1.00 16.33 ? 361  TYR A CE1 1 
ATOM   1028 C  CE2 . TYR A 1 139 ? -21.424 -21.459 0.841   1.00 12.55 ? 361  TYR A CE2 1 
ATOM   1029 C  CZ  . TYR A 1 139 ? -20.212 -21.550 0.189   1.00 16.75 ? 361  TYR A CZ  1 
ATOM   1030 O  OH  . TYR A 1 139 ? -20.205 -21.806 -1.163  1.00 17.06 ? 361  TYR A OH  1 
ATOM   1031 N  N   . PHE A 1 140 ? -17.878 -19.154 5.342   1.00 15.11 ? 362  PHE A N   1 
ATOM   1032 C  CA  . PHE A 1 140 ? -16.560 -18.578 5.111   1.00 19.62 ? 362  PHE A CA  1 
ATOM   1033 C  C   . PHE A 1 140 ? -15.499 -19.624 5.416   1.00 17.06 ? 362  PHE A C   1 
ATOM   1034 O  O   . PHE A 1 140 ? -15.776 -20.655 6.031   1.00 19.36 ? 362  PHE A O   1 
ATOM   1035 C  CB  . PHE A 1 140 ? -16.362 -17.302 5.949   1.00 17.99 ? 362  PHE A CB  1 
ATOM   1036 C  CG  . PHE A 1 140 ? -16.655 -17.473 7.421   1.00 16.81 ? 362  PHE A CG  1 
ATOM   1037 C  CD1 . PHE A 1 140 ? -15.677 -17.933 8.286   1.00 17.47 ? 362  PHE A CD1 1 
ATOM   1038 C  CD2 . PHE A 1 140 ? -17.897 -17.140 7.941   1.00 19.40 ? 362  PHE A CD2 1 
ATOM   1039 C  CE1 . PHE A 1 140 ? -15.932 -18.078 9.633   1.00 18.20 ? 362  PHE A CE1 1 
ATOM   1040 C  CE2 . PHE A 1 140 ? -18.156 -17.282 9.299   1.00 21.38 ? 362  PHE A CE2 1 
ATOM   1041 C  CZ  . PHE A 1 140 ? -17.177 -17.750 10.140  1.00 22.15 ? 362  PHE A CZ  1 
ATOM   1042 N  N   . ASP A 1 141 ? -14.269 -19.344 4.982   1.00 18.06 ? 363  ASP A N   1 
ATOM   1043 C  CA  . ASP A 1 141 ? -13.183 -20.306 5.122   1.00 16.95 ? 363  ASP A CA  1 
ATOM   1044 C  C   . ASP A 1 141 ? -12.781 -20.482 6.578   1.00 18.07 ? 363  ASP A C   1 
ATOM   1045 O  O   . ASP A 1 141 ? -12.728 -19.521 7.353   1.00 21.08 ? 363  ASP A O   1 
ATOM   1046 C  CB  . ASP A 1 141 ? -11.962 -19.864 4.322   1.00 19.97 ? 363  ASP A CB  1 
ATOM   1047 C  CG  . ASP A 1 141 ? -12.146 -20.021 2.837   1.00 32.77 ? 363  ASP A CG  1 
ATOM   1048 O  OD1 . ASP A 1 141 ? -13.152 -20.628 2.409   1.00 26.88 ? 363  ASP A OD1 1 
ATOM   1049 O  OD2 . ASP A 1 141 ? -11.267 -19.537 2.095   1.00 36.04 ? 363  ASP A OD2 1 
ATOM   1050 N  N   . ALA A 1 142 ? -12.459 -21.719 6.941   1.00 17.09 ? 364  ALA A N   1 
ATOM   1051 C  CA  . ALA A 1 142 ? -11.959 -22.012 8.278   1.00 15.83 ? 364  ALA A CA  1 
ATOM   1052 C  C   . ALA A 1 142 ? -11.215 -23.333 8.212   1.00 17.96 ? 364  ALA A C   1 
ATOM   1053 O  O   . ALA A 1 142 ? -11.366 -24.094 7.261   1.00 20.43 ? 364  ALA A O   1 
ATOM   1054 C  CB  . ALA A 1 142 ? -13.095 -22.081 9.309   1.00 16.88 ? 364  ALA A CB  1 
ATOM   1055 N  N   . TYR A 1 143 ? -10.408 -23.605 9.230   1.00 16.36 ? 365  TYR A N   1 
ATOM   1056 C  CA  . TYR A 1 143 ? -9.781  -24.913 9.314   1.00 15.48 ? 365  TYR A CA  1 
ATOM   1057 C  C   . TYR A 1 143 ? -9.983  -25.501 10.698  1.00 16.69 ? 365  TYR A C   1 
ATOM   1058 O  O   . TYR A 1 143 ? -10.204 -24.784 11.678  1.00 16.74 ? 365  TYR A O   1 
ATOM   1059 C  CB  . TYR A 1 143 ? -8.288  -24.886 8.956   1.00 14.00 ? 365  TYR A CB  1 
ATOM   1060 C  CG  . TYR A 1 143 ? -7.367  -24.102 9.869   1.00 17.12 ? 365  TYR A CG  1 
ATOM   1061 C  CD1 . TYR A 1 143 ? -6.832  -24.684 11.013  1.00 18.77 ? 365  TYR A CD1 1 
ATOM   1062 C  CD2 . TYR A 1 143 ? -6.976  -22.807 9.544   1.00 22.52 ? 365  TYR A CD2 1 
ATOM   1063 C  CE1 . TYR A 1 143 ? -5.959  -23.983 11.838  1.00 22.18 ? 365  TYR A CE1 1 
ATOM   1064 C  CE2 . TYR A 1 143 ? -6.108  -22.099 10.359  1.00 20.72 ? 365  TYR A CE2 1 
ATOM   1065 C  CZ  . TYR A 1 143 ? -5.602  -22.692 11.500  1.00 23.83 ? 365  TYR A CZ  1 
ATOM   1066 O  OH  . TYR A 1 143 ? -4.739  -21.993 12.316  1.00 25.90 ? 365  TYR A OH  1 
ATOM   1067 N  N   . LEU A 1 144 ? -9.952  -26.826 10.747  1.00 14.75 ? 366  LEU A N   1 
ATOM   1068 C  CA  . LEU A 1 144 ? -10.059 -27.588 11.985  1.00 14.00 ? 366  LEU A CA  1 
ATOM   1069 C  C   . LEU A 1 144 ? -8.766  -28.381 12.130  1.00 16.71 ? 366  LEU A C   1 
ATOM   1070 O  O   . LEU A 1 144 ? -8.518  -29.311 11.359  1.00 16.73 ? 366  LEU A O   1 
ATOM   1071 C  CB  . LEU A 1 144 ? -11.279 -28.513 11.953  1.00 14.60 ? 366  LEU A CB  1 
ATOM   1072 C  CG  . LEU A 1 144 ? -11.420 -29.455 13.151  1.00 13.11 ? 366  LEU A CG  1 
ATOM   1073 C  CD1 . LEU A 1 144 ? -11.723 -28.665 14.433  1.00 15.55 ? 366  LEU A CD1 1 
ATOM   1074 C  CD2 . LEU A 1 144 ? -12.497 -30.541 12.922  1.00 13.01 ? 366  LEU A CD2 1 
ATOM   1075 N  N   . ASP A 1 145 ? -7.933  -28.019 13.101  1.00 14.56 ? 367  ASP A N   1 
ATOM   1076 C  CA  . ASP A 1 145 ? -6.656  -28.706 13.301  1.00 17.69 ? 367  ASP A CA  1 
ATOM   1077 C  C   . ASP A 1 145 ? -6.836  -29.767 14.387  1.00 18.63 ? 367  ASP A C   1 
ATOM   1078 O  O   . ASP A 1 145 ? -6.778  -29.472 15.583  1.00 17.05 ? 367  ASP A O   1 
ATOM   1079 C  CB  . ASP A 1 145 ? -5.551  -27.714 13.654  1.00 21.14 ? 367  ASP A CB  1 
ATOM   1080 C  CG  . ASP A 1 145 ? -4.173  -28.350 13.629  1.00 24.45 ? 367  ASP A CG  1 
ATOM   1081 O  OD1 . ASP A 1 145 ? -4.083  -29.593 13.682  1.00 18.15 ? 367  ASP A OD1 1 
ATOM   1082 O  OD2 . ASP A 1 145 ? -3.174  -27.608 13.553  1.00 23.83 ? 367  ASP A OD2 1 
ATOM   1083 N  N   . THR A 1 146 ? -7.023  -31.018 13.968  1.00 13.75 ? 368  THR A N   1 
ATOM   1084 C  CA  . THR A 1 146 ? -7.300  -32.091 14.912  1.00 12.48 ? 368  THR A CA  1 
ATOM   1085 C  C   . THR A 1 146 ? -6.039  -32.646 15.569  1.00 17.41 ? 368  THR A C   1 
ATOM   1086 O  O   . THR A 1 146 ? -6.106  -33.672 16.257  1.00 16.48 ? 368  THR A O   1 
ATOM   1087 C  CB  . THR A 1 146 ? -8.074  -33.205 14.210  1.00 15.95 ? 368  THR A CB  1 
ATOM   1088 O  OG1 . THR A 1 146 ? -7.304  -33.695 13.110  1.00 16.56 ? 368  THR A OG1 1 
ATOM   1089 C  CG2 . THR A 1 146 ? -9.394  -32.654 13.697  1.00 12.99 ? 368  THR A CG2 1 
ATOM   1090 N  N   . ARG A 1 147 ? -4.898  -31.989 15.374  1.00 17.49 ? 369  ARG A N   1 
ATOM   1091 C  CA  . ARG A 1 147 ? -3.673  -32.354 16.062  1.00 20.38 ? 369  ARG A CA  1 
ATOM   1092 C  C   . ARG A 1 147 ? -3.530  -31.673 17.418  1.00 25.45 ? 369  ARG A C   1 
ATOM   1093 O  O   . ARG A 1 147 ? -2.666  -32.081 18.200  1.00 22.80 ? 369  ARG A O   1 
ATOM   1094 C  CB  . ARG A 1 147 ? -2.457  -32.002 15.192  1.00 18.32 ? 369  ARG A CB  1 
ATOM   1095 C  CG  . ARG A 1 147 ? -2.459  -32.647 13.812  1.00 20.50 ? 369  ARG A CG  1 
ATOM   1096 C  CD  . ARG A 1 147 ? -1.368  -32.062 12.929  1.00 18.82 ? 369  ARG A CD  1 
ATOM   1097 N  NE  . ARG A 1 147 ? -1.570  -30.636 12.698  1.00 21.47 ? 369  ARG A NE  1 
ATOM   1098 C  CZ  . ARG A 1 147 ? -0.749  -29.860 12.003  1.00 23.25 ? 369  ARG A CZ  1 
ATOM   1099 N  NH1 . ARG A 1 147 ? 0.336   -30.347 11.416  1.00 22.46 ? 369  ARG A NH1 1 
ATOM   1100 N  NH2 . ARG A 1 147 ? -1.013  -28.561 11.907  1.00 25.40 ? 369  ARG A NH2 1 
ATOM   1101 N  N   . GLN A 1 148 ? -4.355  -30.667 17.722  1.00 21.22 ? 370  GLN A N   1 
ATOM   1102 C  CA  . GLN A 1 148 ? -4.140  -29.778 18.863  1.00 17.68 ? 370  GLN A CA  1 
ATOM   1103 C  C   . GLN A 1 148 ? -5.010  -30.184 20.047  1.00 22.31 ? 370  GLN A C   1 
ATOM   1104 O  O   . GLN A 1 148 ? -6.241  -30.183 19.947  1.00 21.26 ? 370  GLN A O   1 
ATOM   1105 C  CB  . GLN A 1 148 ? -4.436  -28.323 18.489  1.00 18.37 ? 370  GLN A CB  1 
ATOM   1106 C  CG  . GLN A 1 148 ? -3.744  -27.815 17.230  1.00 23.86 ? 370  GLN A CG  1 
ATOM   1107 C  CD  . GLN A 1 148 ? -2.232  -27.999 17.265  1.00 38.61 ? 370  GLN A CD  1 
ATOM   1108 O  OE1 . GLN A 1 148 ? -1.615  -27.973 18.333  1.00 39.58 ? 370  GLN A OE1 1 
ATOM   1109 N  NE2 . GLN A 1 148 ? -1.629  -28.196 16.090  1.00 32.02 ? 370  GLN A NE2 1 
ATOM   1110 N  N   . HIS A 1 149 ? -4.371  -30.479 21.182  1.00 20.17 ? 371  HIS A N   1 
ATOM   1111 C  CA  . HIS A 1 149 ? -5.115  -30.830 22.390  1.00 25.05 ? 371  HIS A CA  1 
ATOM   1112 C  C   . HIS A 1 149 ? -5.987  -29.686 22.896  1.00 23.67 ? 371  HIS A C   1 
ATOM   1113 O  O   . HIS A 1 149 ? -7.061  -29.929 23.457  1.00 25.21 ? 371  HIS A O   1 
ATOM   1114 C  CB  . HIS A 1 149 ? -4.145  -31.245 23.500  1.00 28.84 ? 371  HIS A CB  1 
ATOM   1115 C  CG  . HIS A 1 149 ? -3.560  -32.605 23.311  1.00 31.36 ? 371  HIS A CG  1 
ATOM   1116 N  ND1 . HIS A 1 149 ? -2.687  -33.171 24.214  1.00 37.20 ? 371  HIS A ND1 1 
ATOM   1117 C  CD2 . HIS A 1 149 ? -3.717  -33.511 22.317  1.00 25.71 ? 371  HIS A CD2 1 
ATOM   1118 C  CE1 . HIS A 1 149 ? -2.332  -34.369 23.785  1.00 34.36 ? 371  HIS A CE1 1 
ATOM   1119 N  NE2 . HIS A 1 149 ? -2.943  -34.599 22.637  1.00 31.31 ? 371  HIS A NE2 1 
ATOM   1120 N  N   . GLY A 1 150 ? -5.536  -28.440 22.747  1.00 23.14 ? 372  GLY A N   1 
ATOM   1121 C  CA  . GLY A 1 150 ? -6.235  -27.336 23.382  1.00 22.39 ? 372  GLY A CA  1 
ATOM   1122 C  C   . GLY A 1 150 ? -7.527  -26.954 22.706  1.00 25.89 ? 372  GLY A C   1 
ATOM   1123 O  O   . GLY A 1 150 ? -8.467  -26.505 23.370  1.00 25.96 ? 372  GLY A O   1 
ATOM   1124 N  N   . THR A 1 151 ? -7.600  -27.125 21.390  1.00 19.75 ? 373  THR A N   1 
ATOM   1125 C  CA  . THR A 1 151 ? -8.755  -26.700 20.616  1.00 19.15 ? 373  THR A CA  1 
ATOM   1126 C  C   . THR A 1 151 ? -9.495  -27.853 19.956  1.00 20.86 ? 373  THR A C   1 
ATOM   1127 O  O   . THR A 1 151 ? -10.518 -27.619 19.299  1.00 23.01 ? 373  THR A O   1 
ATOM   1128 C  CB  . THR A 1 151 ? -8.328  -25.692 19.542  1.00 20.84 ? 373  THR A CB  1 
ATOM   1129 O  OG1 . THR A 1 151 ? -7.099  -26.132 18.951  1.00 21.56 ? 373  THR A OG1 1 
ATOM   1130 C  CG2 . THR A 1 151 ? -8.122  -24.298 20.151  1.00 21.58 ? 373  THR A CG2 1 
ATOM   1131 N  N   . PHE A 1 152 ? -9.014  -29.091 20.092  1.00 17.94 ? 374  PHE A N   1 
ATOM   1132 C  CA  . PHE A 1 152 ? -9.735  -30.248 19.548  1.00 19.01 ? 374  PHE A CA  1 
ATOM   1133 C  C   . PHE A 1 152 ? -9.813  -31.327 20.613  1.00 18.55 ? 374  PHE A C   1 
ATOM   1134 O  O   . PHE A 1 152 ? -9.039  -32.284 20.628  1.00 20.98 ? 374  PHE A O   1 
ATOM   1135 C  CB  . PHE A 1 152 ? -9.106  -30.776 18.266  1.00 16.09 ? 374  PHE A CB  1 
ATOM   1136 C  CG  . PHE A 1 152 ? -9.930  -31.859 17.619  1.00 13.92 ? 374  PHE A CG  1 
ATOM   1137 C  CD1 . PHE A 1 152 ? -11.161 -31.556 17.062  1.00 15.01 ? 374  PHE A CD1 1 
ATOM   1138 C  CD2 . PHE A 1 152 ? -9.493  -33.177 17.607  1.00 18.03 ? 374  PHE A CD2 1 
ATOM   1139 C  CE1 . PHE A 1 152 ? -11.939 -32.544 16.474  1.00 15.75 ? 374  PHE A CE1 1 
ATOM   1140 C  CE2 . PHE A 1 152 ? -10.261 -34.171 17.013  1.00 20.26 ? 374  PHE A CE2 1 
ATOM   1141 C  CZ  . PHE A 1 152 ? -11.484 -33.851 16.449  1.00 17.60 ? 374  PHE A CZ  1 
ATOM   1142 N  N   . ALA A 1 153 ? -10.771 -31.170 21.514  1.00 16.26 ? 375  ALA A N   1 
ATOM   1143 C  CA  . ALA A 1 153 ? -11.075 -32.168 22.537  1.00 16.98 ? 375  ALA A CA  1 
ATOM   1144 C  C   . ALA A 1 153 ? -12.577 -32.428 22.527  1.00 18.75 ? 375  ALA A C   1 
ATOM   1145 O  O   . ALA A 1 153 ? -13.283 -32.157 23.511  1.00 18.76 ? 375  ALA A O   1 
ATOM   1146 C  CB  . ALA A 1 153 ? -10.587 -31.701 23.911  1.00 19.40 ? 375  ALA A CB  1 
ATOM   1147 N  N   . PRO A 1 154 ? -13.097 -32.987 21.424  1.00 14.31 ? 376  PRO A N   1 
ATOM   1148 C  CA  . PRO A 1 154 ? -14.557 -33.106 21.271  1.00 16.77 ? 376  PRO A CA  1 
ATOM   1149 C  C   . PRO A 1 154 ? -15.235 -33.989 22.310  1.00 15.50 ? 376  PRO A C   1 
ATOM   1150 O  O   . PRO A 1 154 ? -16.436 -33.807 22.559  1.00 17.49 ? 376  PRO A O   1 
ATOM   1151 C  CB  . PRO A 1 154 ? -14.707 -33.685 19.855  1.00 15.58 ? 376  PRO A CB  1 
ATOM   1152 C  CG  . PRO A 1 154 ? -13.421 -34.431 19.629  1.00 13.11 ? 376  PRO A CG  1 
ATOM   1153 C  CD  . PRO A 1 154 ? -12.368 -33.584 20.290  1.00 16.36 ? 376  PRO A CD  1 
ATOM   1154 N  N   . TYR A 1 155 ? -14.513 -34.934 22.922  1.00 15.81 ? 377  TYR A N   1 
ATOM   1155 C  CA  . TYR A 1 155 ? -15.106 -35.737 23.990  1.00 16.19 ? 377  TYR A CA  1 
ATOM   1156 C  C   . TYR A 1 155 ? -15.591 -34.863 25.139  1.00 19.63 ? 377  TYR A C   1 
ATOM   1157 O  O   . TYR A 1 155 ? -16.522 -35.250 25.860  1.00 17.37 ? 377  TYR A O   1 
ATOM   1158 C  CB  . TYR A 1 155 ? -14.098 -36.760 24.507  1.00 17.06 ? 377  TYR A CB  1 
ATOM   1159 C  CG  . TYR A 1 155 ? -14.631 -37.739 25.546  1.00 20.59 ? 377  TYR A CG  1 
ATOM   1160 C  CD1 . TYR A 1 155 ? -15.594 -38.692 25.211  1.00 16.58 ? 377  TYR A CD1 1 
ATOM   1161 C  CD2 . TYR A 1 155 ? -14.142 -37.733 26.850  1.00 19.89 ? 377  TYR A CD2 1 
ATOM   1162 C  CE1 . TYR A 1 155 ? -16.061 -39.609 26.142  1.00 19.66 ? 377  TYR A CE1 1 
ATOM   1163 C  CE2 . TYR A 1 155 ? -14.606 -38.641 27.790  1.00 19.92 ? 377  TYR A CE2 1 
ATOM   1164 C  CZ  . TYR A 1 155 ? -15.557 -39.571 27.441  1.00 21.36 ? 377  TYR A CZ  1 
ATOM   1165 O  OH  . TYR A 1 155 ? -16.006 -40.469 28.381  1.00 20.15 ? 377  TYR A OH  1 
ATOM   1166 N  N   . THR A 1 156 ? -14.991 -33.683 25.312  1.00 21.77 ? 378  THR A N   1 
ATOM   1167 C  CA  . THR A 1 156 ? -15.404 -32.753 26.361  1.00 20.07 ? 378  THR A CA  1 
ATOM   1168 C  C   . THR A 1 156 ? -16.576 -31.876 25.959  1.00 22.89 ? 378  THR A C   1 
ATOM   1169 O  O   . THR A 1 156 ? -17.048 -31.090 26.787  1.00 20.71 ? 378  THR A O   1 
ATOM   1170 C  CB  . THR A 1 156 ? -14.250 -31.839 26.760  1.00 21.94 ? 378  THR A CB  1 
ATOM   1171 O  OG1 . THR A 1 156 ? -14.007 -30.896 25.706  1.00 20.76 ? 378  THR A OG1 1 
ATOM   1172 C  CG2 . THR A 1 156 ? -13.004 -32.642 27.036  1.00 19.46 ? 378  THR A CG2 1 
ATOM   1173 N  N   . GLY A 1 157 ? -17.043 -31.969 24.714  1.00 17.52 ? 379  GLY A N   1 
ATOM   1174 C  CA  . GLY A 1 157 ? -18.189 -31.201 24.282  1.00 16.10 ? 379  GLY A CA  1 
ATOM   1175 C  C   . GLY A 1 157 ? -17.858 -29.873 23.644  1.00 16.77 ? 379  GLY A C   1 
ATOM   1176 O  O   . GLY A 1 157 ? -18.780 -29.146 23.259  1.00 21.35 ? 379  GLY A O   1 
ATOM   1177 N  N   . HIS A 1 158 ? -16.578 -29.536 23.510  1.00 21.10 ? 380  HIS A N   1 
ATOM   1178 C  CA  . HIS A 1 158 ? -16.174 -28.284 22.888  1.00 22.47 ? 380  HIS A CA  1 
ATOM   1179 C  C   . HIS A 1 158 ? -15.036 -28.535 21.918  1.00 19.02 ? 380  HIS A C   1 
ATOM   1180 O  O   . HIS A 1 158 ? -14.205 -29.424 22.123  1.00 22.36 ? 380  HIS A O   1 
ATOM   1181 C  CB  . HIS A 1 158 ? -15.703 -27.236 23.911  1.00 25.93 ? 380  HIS A CB  1 
ATOM   1182 C  CG  . HIS A 1 158 ? -16.649 -27.028 25.048  1.00 30.91 ? 380  HIS A CG  1 
ATOM   1183 N  ND1 . HIS A 1 158 ? -17.866 -26.398 24.900  1.00 30.16 ? 380  HIS A ND1 1 
ATOM   1184 C  CD2 . HIS A 1 158 ? -16.550 -27.354 26.358  1.00 30.16 ? 380  HIS A CD2 1 
ATOM   1185 C  CE1 . HIS A 1 158 ? -18.480 -26.351 26.070  1.00 30.17 ? 380  HIS A CE1 1 
ATOM   1186 N  NE2 . HIS A 1 158 ? -17.703 -26.925 26.970  1.00 41.41 ? 380  HIS A NE2 1 
ATOM   1187 N  N   . ALA A 1 159 ? -14.997 -27.717 20.869  1.00 19.19 ? 381  ALA A N   1 
ATOM   1188 C  CA  . ALA A 1 159 ? -13.885 -27.700 19.930  1.00 19.23 ? 381  ALA A CA  1 
ATOM   1189 C  C   . ALA A 1 159 ? -13.912 -26.357 19.227  1.00 15.38 ? 381  ALA A C   1 
ATOM   1190 O  O   . ALA A 1 159 ? -14.944 -25.686 19.188  1.00 16.27 ? 381  ALA A O   1 
ATOM   1191 C  CB  . ALA A 1 159 ? -13.969 -28.847 18.915  1.00 22.83 ? 381  ALA A CB  1 
ATOM   1192 N  N   . ALA A 1 160 ? -12.770 -25.959 18.681  1.00 16.32 ? 382  ALA A N   1 
ATOM   1193 C  CA  . ALA A 1 160 ? -12.690 -24.710 17.939  1.00 17.07 ? 382  ALA A CA  1 
ATOM   1194 C  C   . ALA A 1 160 ? -12.149 -24.960 16.540  1.00 17.29 ? 382  ALA A C   1 
ATOM   1195 O  O   . ALA A 1 160 ? -11.194 -25.723 16.367  1.00 18.93 ? 382  ALA A O   1 
ATOM   1196 C  CB  . ALA A 1 160 ? -11.797 -23.687 18.653  1.00 18.45 ? 382  ALA A CB  1 
ATOM   1197 N  N   . VAL A 1 161 ? -12.760 -24.307 15.549  1.00 15.07 ? 383  VAL A N   1 
ATOM   1198 C  CA  . VAL A 1 161 ? -12.115 -24.122 14.255  1.00 13.65 ? 383  VAL A CA  1 
ATOM   1199 C  C   . VAL A 1 161 ? -11.331 -22.818 14.313  1.00 20.12 ? 383  VAL A C   1 
ATOM   1200 O  O   . VAL A 1 161 ? -11.453 -22.053 15.277  1.00 24.22 ? 383  VAL A O   1 
ATOM   1201 C  CB  . VAL A 1 161 ? -13.127 -24.108 13.093  1.00 15.68 ? 383  VAL A CB  1 
ATOM   1202 C  CG1 . VAL A 1 161 ? -13.915 -25.419 13.051  1.00 16.98 ? 383  VAL A CG1 1 
ATOM   1203 C  CG2 . VAL A 1 161 ? -14.064 -22.903 13.188  1.00 19.26 ? 383  VAL A CG2 1 
ATOM   1204 N  N   . HIS A 1 162 ? -10.521 -22.555 13.296  1.00 15.49 ? 384  HIS A N   1 
ATOM   1205 C  CA  . HIS A 1 162 ? -9.747  -21.322 13.220  1.00 20.85 ? 384  HIS A CA  1 
ATOM   1206 C  C   . HIS A 1 162 ? -10.051 -20.606 11.916  1.00 21.39 ? 384  HIS A C   1 
ATOM   1207 O  O   . HIS A 1 162 ? -10.183 -21.239 10.864  1.00 21.74 ? 384  HIS A O   1 
ATOM   1208 C  CB  . HIS A 1 162 ? -8.244  -21.601 13.337  1.00 18.22 ? 384  HIS A CB  1 
ATOM   1209 C  CG  . HIS A 1 162 ? -7.826  -22.008 14.713  1.00 20.89 ? 384  HIS A CG  1 
ATOM   1210 N  ND1 . HIS A 1 162 ? -7.987  -23.292 15.189  1.00 22.72 ? 384  HIS A ND1 1 
ATOM   1211 C  CD2 . HIS A 1 162 ? -7.298  -21.291 15.734  1.00 20.27 ? 384  HIS A CD2 1 
ATOM   1212 C  CE1 . HIS A 1 162 ? -7.563  -23.352 16.439  1.00 25.96 ? 384  HIS A CE1 1 
ATOM   1213 N  NE2 . HIS A 1 162 ? -7.138  -22.151 16.793  1.00 22.45 ? 384  HIS A NE2 1 
ATOM   1214 N  N   . SER A 1 163 ? -10.146 -19.280 11.983  1.00 17.69 ? 385  SER A N   1 
ATOM   1215 C  CA  . SER A 1 163 ? -10.546 -18.512 10.811  1.00 20.07 ? 385  SER A CA  1 
ATOM   1216 C  C   . SER A 1 163 ? -10.005 -17.099 10.945  1.00 23.85 ? 385  SER A C   1 
ATOM   1217 O  O   . SER A 1 163 ? -9.822  -16.600 12.057  1.00 24.42 ? 385  SER A O   1 
ATOM   1218 C  CB  . SER A 1 163 ? -12.073 -18.480 10.665  1.00 17.18 ? 385  SER A CB  1 
ATOM   1219 O  OG  . SER A 1 163 ? -12.471 -17.835 9.469   1.00 18.90 ? 385  SER A OG  1 
ATOM   1220 N  N   . ASP A 1 164 ? -9.753  -16.464 9.803   1.00 20.66 ? 386  ASP A N   1 
ATOM   1221 C  CA  . ASP A 1 164 ? -9.533  -15.025 9.761   1.00 26.51 ? 386  ASP A CA  1 
ATOM   1222 C  C   . ASP A 1 164 ? -10.656 -14.300 9.021   1.00 30.97 ? 386  ASP A C   1 
ATOM   1223 O  O   . ASP A 1 164 ? -10.501 -13.126 8.663   1.00 28.23 ? 386  ASP A O   1 
ATOM   1224 C  CB  . ASP A 1 164 ? -8.167  -14.708 9.139   1.00 27.91 ? 386  ASP A CB  1 
ATOM   1225 C  CG  . ASP A 1 164 ? -8.132  -14.893 7.625   1.00 36.94 ? 386  ASP A CG  1 
ATOM   1226 O  OD1 . ASP A 1 164 ? -8.939  -15.667 7.064   1.00 27.81 ? 386  ASP A OD1 1 
ATOM   1227 O  OD2 . ASP A 1 164 ? -7.267  -14.257 6.984   1.00 44.76 ? 386  ASP A OD2 1 
ATOM   1228 N  N   . GLN A 1 165 ? -11.797 -14.969 8.812   1.00 23.51 ? 387  GLN A N   1 
ATOM   1229 C  CA  A GLN A 1 165 ? -12.911 -14.423 8.044   0.59 20.83 ? 387  GLN A CA  1 
ATOM   1230 C  CA  B GLN A 1 165 ? -12.905 -14.397 8.052   0.41 20.90 ? 387  GLN A CA  1 
ATOM   1231 C  C   . GLN A 1 165 ? -14.201 -14.314 8.852   1.00 22.64 ? 387  GLN A C   1 
ATOM   1232 O  O   . GLN A 1 165 ? -15.263 -14.051 8.272   1.00 24.17 ? 387  GLN A O   1 
ATOM   1233 C  CB  A GLN A 1 165 ? -13.166 -15.283 6.800   0.59 22.09 ? 387  GLN A CB  1 
ATOM   1234 C  CB  B GLN A 1 165 ? -13.140 -15.204 6.769   0.41 22.18 ? 387  GLN A CB  1 
ATOM   1235 C  CG  A GLN A 1 165 ? -11.947 -15.508 5.920   0.59 25.00 ? 387  GLN A CG  1 
ATOM   1236 C  CG  B GLN A 1 165 ? -12.016 -15.100 5.751   0.41 25.32 ? 387  GLN A CG  1 
ATOM   1237 C  CD  A GLN A 1 165 ? -11.491 -14.245 5.224   0.59 29.53 ? 387  GLN A CD  1 
ATOM   1238 C  CD  B GLN A 1 165 ? -12.261 -15.945 4.517   0.41 29.46 ? 387  GLN A CD  1 
ATOM   1239 O  OE1 A GLN A 1 165 ? -12.295 -13.533 4.626   0.59 31.89 ? 387  GLN A OE1 1 
ATOM   1240 O  OE1 B GLN A 1 165 ? -13.290 -16.614 4.399   0.41 22.79 ? 387  GLN A OE1 1 
ATOM   1241 N  NE2 A GLN A 1 165 ? -10.193 -13.957 5.300   0.59 30.01 ? 387  GLN A NE2 1 
ATOM   1242 N  NE2 B GLN A 1 165 ? -11.312 -15.920 3.587   0.41 30.05 ? 387  GLN A NE2 1 
ATOM   1243 N  N   . GLN A 1 166 ? -14.150 -14.510 10.164  1.00 20.47 ? 388  GLN A N   1 
ATOM   1244 C  CA  A GLN A 1 166 ? -15.393 -14.577 10.914  0.66 20.19 ? 388  GLN A CA  1 
ATOM   1245 C  CA  B GLN A 1 166 ? -15.357 -14.586 10.980  0.34 20.35 ? 388  GLN A CA  1 
ATOM   1246 C  C   . GLN A 1 166 ? -15.916 -13.214 11.348  1.00 28.32 ? 388  GLN A C   1 
ATOM   1247 O  O   . GLN A 1 166 ? -17.118 -13.091 11.614  1.00 27.36 ? 388  GLN A O   1 
ATOM   1248 C  CB  A GLN A 1 166 ? -15.232 -15.475 12.146  0.66 24.58 ? 388  GLN A CB  1 
ATOM   1249 C  CB  B GLN A 1 166 ? -15.059 -15.375 12.259  0.34 24.56 ? 388  GLN A CB  1 
ATOM   1250 C  CG  A GLN A 1 166 ? -14.312 -14.938 13.228  0.66 21.99 ? 388  GLN A CG  1 
ATOM   1251 C  CG  B GLN A 1 166 ? -16.149 -15.307 13.318  0.34 19.46 ? 388  GLN A CG  1 
ATOM   1252 C  CD  A GLN A 1 166 ? -12.862 -15.337 13.023  0.66 20.32 ? 388  GLN A CD  1 
ATOM   1253 C  CD  B GLN A 1 166 ? -15.603 -15.314 14.727  0.34 26.09 ? 388  GLN A CD  1 
ATOM   1254 O  OE1 A GLN A 1 166 ? -12.272 -15.072 11.974  0.66 26.64 ? 388  GLN A OE1 1 
ATOM   1255 O  OE1 B GLN A 1 166 ? -14.439 -15.639 14.954  0.34 28.84 ? 388  GLN A OE1 1 
ATOM   1256 N  NE2 A GLN A 1 166 ? -12.275 -15.970 14.035  0.66 24.58 ? 388  GLN A NE2 1 
ATOM   1257 N  NE2 B GLN A 1 166 ? -16.444 -14.947 15.688  0.34 23.59 ? 388  GLN A NE2 1 
ATOM   1258 N  N   . ALA A 1 167 ? -15.070 -12.186 11.372  1.00 26.87 ? 389  ALA A N   1 
ATOM   1259 C  CA  . ALA A 1 167 ? -15.410 -10.918 12.018  1.00 33.34 ? 389  ALA A CA  1 
ATOM   1260 C  C   . ALA A 1 167 ? -16.786 -10.407 11.622  1.00 26.65 ? 389  ALA A C   1 
ATOM   1261 O  O   . ALA A 1 167 ? -17.060 -10.169 10.442  1.00 37.97 ? 389  ALA A O   1 
ATOM   1262 C  CB  . ALA A 1 167 ? -14.346 -9.869  11.694  1.00 45.61 ? 389  ALA A CB  1 
ATOM   1263 N  N   . GLY A 1 168 ? -17.652 -10.258 12.624  1.00 28.07 ? 390  GLY A N   1 
ATOM   1264 C  CA  . GLY A 1 168 ? -18.962 -9.672  12.452  1.00 28.18 ? 390  GLY A CA  1 
ATOM   1265 C  C   . GLY A 1 168 ? -20.075 -10.641 12.117  1.00 34.75 ? 390  GLY A C   1 
ATOM   1266 O  O   . GLY A 1 168 ? -21.248 -10.247 12.149  1.00 29.13 ? 390  GLY A O   1 
ATOM   1267 N  N   . HIS A 1 169 ? -19.759 -11.898 11.816  1.00 22.73 ? 391  HIS A N   1 
ATOM   1268 C  CA  . HIS A 1 169 ? -20.747 -12.809 11.261  1.00 22.93 ? 391  HIS A CA  1 
ATOM   1269 C  C   . HIS A 1 169 ? -21.353 -13.765 12.279  1.00 23.94 ? 391  HIS A C   1 
ATOM   1270 O  O   . HIS A 1 169 ? -22.342 -14.432 11.953  1.00 21.23 ? 391  HIS A O   1 
ATOM   1271 C  CB  . HIS A 1 169 ? -20.124 -13.616 10.114  1.00 20.43 ? 391  HIS A CB  1 
ATOM   1272 C  CG  . HIS A 1 169 ? -19.715 -12.776 8.948   1.00 23.79 ? 391  HIS A CG  1 
ATOM   1273 N  ND1 . HIS A 1 169 ? -20.589 -11.929 8.301   1.00 25.70 ? 391  HIS A ND1 1 
ATOM   1274 C  CD2 . HIS A 1 169 ? -18.526 -12.647 8.314   1.00 25.20 ? 391  HIS A CD2 1 
ATOM   1275 C  CE1 . HIS A 1 169 ? -19.957 -11.315 7.317   1.00 28.25 ? 391  HIS A CE1 1 
ATOM   1276 N  NE2 . HIS A 1 169 ? -18.705 -11.736 7.301   1.00 28.48 ? 391  HIS A NE2 1 
ATOM   1277 N  N   . LEU A 1 170 ? -20.811 -13.847 13.495  1.00 20.30 ? 392  LEU A N   1 
ATOM   1278 C  CA  . LEU A 1 170 ? -21.300 -14.802 14.476  1.00 20.19 ? 392  LEU A CA  1 
ATOM   1279 C  C   . LEU A 1 170 ? -21.673 -14.093 15.769  1.00 22.29 ? 392  LEU A C   1 
ATOM   1280 O  O   . LEU A 1 170 ? -21.045 -13.106 16.160  1.00 26.89 ? 392  LEU A O   1 
ATOM   1281 C  CB  . LEU A 1 170 ? -20.257 -15.885 14.777  1.00 21.53 ? 392  LEU A CB  1 
ATOM   1282 C  CG  . LEU A 1 170 ? -19.800 -16.710 13.571  1.00 23.87 ? 392  LEU A CG  1 
ATOM   1283 C  CD1 . LEU A 1 170 ? -18.736 -17.693 14.011  1.00 27.61 ? 392  LEU A CD1 1 
ATOM   1284 C  CD2 . LEU A 1 170 ? -20.971 -17.430 12.927  1.00 25.14 ? 392  LEU A CD2 1 
ATOM   1285 N  N   . ALA A 1 171 ? -22.703 -14.613 16.425  1.00 21.72 ? 393  ALA A N   1 
ATOM   1286 C  CA  . ALA A 1 171 ? -23.077 -14.172 17.760  1.00 25.07 ? 393  ALA A CA  1 
ATOM   1287 C  C   . ALA A 1 171 ? -23.369 -15.396 18.613  1.00 23.32 ? 393  ALA A C   1 
ATOM   1288 O  O   . ALA A 1 171 ? -23.681 -16.474 18.099  1.00 23.31 ? 393  ALA A O   1 
ATOM   1289 C  CB  . ALA A 1 171 ? -24.294 -13.243 17.738  1.00 23.36 ? 393  ALA A CB  1 
ATOM   1290 N  N   . GLN A 1 172 ? -23.266 -15.212 19.930  1.00 22.06 ? 394  GLN A N   1 
ATOM   1291 C  CA  . GLN A 1 172 ? -23.496 -16.281 20.893  1.00 21.60 ? 394  GLN A CA  1 
ATOM   1292 C  C   . GLN A 1 172 ? -24.716 -17.113 20.520  1.00 23.41 ? 394  GLN A C   1 
ATOM   1293 O  O   . GLN A 1 172 ? -25.796 -16.573 20.275  1.00 22.74 ? 394  GLN A O   1 
ATOM   1294 C  CB  . GLN A 1 172 ? -23.689 -15.677 22.287  1.00 25.82 ? 394  GLN A CB  1 
ATOM   1295 C  CG  . GLN A 1 172 ? -23.964 -16.694 23.367  1.00 20.38 ? 394  GLN A CG  1 
ATOM   1296 C  CD  . GLN A 1 172 ? -22.754 -17.528 23.707  1.00 21.79 ? 394  GLN A CD  1 
ATOM   1297 O  OE1 . GLN A 1 172 ? -21.614 -17.093 23.550  1.00 27.31 ? 394  GLN A OE1 1 
ATOM   1298 N  NE2 . GLN A 1 172 ? -22.995 -18.737 24.187  1.00 28.91 ? 394  GLN A NE2 1 
ATOM   1299 N  N   . GLY A 1 173 ? -24.527 -18.436 20.447  1.00 19.91 ? 395  GLY A N   1 
ATOM   1300 C  CA  . GLY A 1 173 ? -25.615 -19.361 20.213  1.00 19.51 ? 395  GLY A CA  1 
ATOM   1301 C  C   . GLY A 1 173 ? -25.928 -19.691 18.766  1.00 17.35 ? 395  GLY A C   1 
ATOM   1302 O  O   . GLY A 1 173 ? -26.759 -20.581 18.524  1.00 19.38 ? 395  GLY A O   1 
ATOM   1303 N  N   . TYR A 1 174 ? -25.329 -18.995 17.801  1.00 20.03 ? 396  TYR A N   1 
ATOM   1304 C  CA  . TYR A 1 174 ? -25.585 -19.304 16.394  1.00 19.21 ? 396  TYR A CA  1 
ATOM   1305 C  C   . TYR A 1 174 ? -25.180 -20.741 16.088  1.00 17.84 ? 396  TYR A C   1 
ATOM   1306 O  O   . TYR A 1 174 ? -24.110 -21.190 16.492  1.00 18.56 ? 396  TYR A O   1 
ATOM   1307 C  CB  . TYR A 1 174 ? -24.795 -18.369 15.477  1.00 19.56 ? 396  TYR A CB  1 
ATOM   1308 C  CG  . TYR A 1 174 ? -25.359 -16.981 15.278  1.00 20.71 ? 396  TYR A CG  1 
ATOM   1309 C  CD1 . TYR A 1 174 ? -26.352 -16.478 16.101  1.00 27.94 ? 396  TYR A CD1 1 
ATOM   1310 C  CD2 . TYR A 1 174 ? -24.894 -16.179 14.247  1.00 20.57 ? 396  TYR A CD2 1 
ATOM   1311 C  CE1 . TYR A 1 174 ? -26.855 -15.199 15.905  1.00 24.95 ? 396  TYR A CE1 1 
ATOM   1312 C  CE2 . TYR A 1 174 ? -25.391 -14.908 14.043  1.00 23.12 ? 396  TYR A CE2 1 
ATOM   1313 C  CZ  . TYR A 1 174 ? -26.370 -14.425 14.870  1.00 26.54 ? 396  TYR A CZ  1 
ATOM   1314 O  OH  . TYR A 1 174 ? -26.853 -13.154 14.653  1.00 29.48 ? 396  TYR A OH  1 
ATOM   1315 N  N   A LYS A 1 175 ? -26.032 -21.459 15.364  0.40 21.04 ? 397  LYS A N   1 
ATOM   1316 N  N   B LYS A 1 175 ? -26.047 -21.460 15.375  0.60 21.05 ? 397  LYS A N   1 
ATOM   1317 C  CA  A LYS A 1 175 ? -25.670 -22.793 14.899  0.40 20.89 ? 397  LYS A CA  1 
ATOM   1318 C  CA  B LYS A 1 175 ? -25.683 -22.777 14.860  0.60 20.96 ? 397  LYS A CA  1 
ATOM   1319 C  C   A LYS A 1 175 ? -24.681 -22.685 13.743  0.40 17.63 ? 397  LYS A C   1 
ATOM   1320 C  C   B LYS A 1 175 ? -24.644 -22.635 13.755  0.60 17.59 ? 397  LYS A C   1 
ATOM   1321 O  O   A LYS A 1 175 ? -24.912 -21.944 12.782  0.40 17.81 ? 397  LYS A O   1 
ATOM   1322 O  O   B LYS A 1 175 ? -24.811 -21.836 12.827  0.60 17.76 ? 397  LYS A O   1 
ATOM   1323 C  CB  A LYS A 1 175 ? -26.913 -23.575 14.474  0.40 19.87 ? 397  LYS A CB  1 
ATOM   1324 C  CB  B LYS A 1 175 ? -26.912 -23.505 14.317  0.60 19.62 ? 397  LYS A CB  1 
ATOM   1325 C  CG  A LYS A 1 175 ? -27.751 -24.084 15.644  0.40 21.06 ? 397  LYS A CG  1 
ATOM   1326 C  CG  B LYS A 1 175 ? -27.884 -24.034 15.361  0.60 21.86 ? 397  LYS A CG  1 
ATOM   1327 C  CD  A LYS A 1 175 ? -28.966 -24.867 15.166  0.40 25.72 ? 397  LYS A CD  1 
ATOM   1328 C  CD  B LYS A 1 175 ? -29.018 -24.779 14.660  0.60 25.43 ? 397  LYS A CD  1 
ATOM   1329 C  CE  A LYS A 1 175 ? -29.852 -25.287 16.328  0.40 29.00 ? 397  LYS A CE  1 
ATOM   1330 C  CE  B LYS A 1 175 ? -30.124 -25.185 15.607  0.60 35.95 ? 397  LYS A CE  1 
ATOM   1331 N  NZ  A LYS A 1 175 ? -29.161 -26.228 17.252  0.40 35.09 ? 397  LYS A NZ  1 
ATOM   1332 N  NZ  B LYS A 1 175 ? -31.222 -25.843 14.843  0.60 38.97 ? 397  LYS A NZ  1 
ATOM   1333 N  N   . ILE A 1 176 ? -23.573 -23.419 13.844  1.00 19.26 ? 398  ILE A N   1 
ATOM   1334 C  CA  . ILE A 1 176 ? -22.515 -23.389 12.842  1.00 15.97 ? 398  ILE A CA  1 
ATOM   1335 C  C   . ILE A 1 176 ? -22.026 -24.806 12.593  1.00 16.61 ? 398  ILE A C   1 
ATOM   1336 O  O   . ILE A 1 176 ? -21.985 -25.640 13.500  1.00 14.37 ? 398  ILE A O   1 
ATOM   1337 C  CB  . ILE A 1 176 ? -21.339 -22.483 13.273  1.00 15.24 ? 398  ILE A CB  1 
ATOM   1338 C  CG1 . ILE A 1 176 ? -21.036 -22.693 14.765  1.00 16.65 ? 398  ILE A CG1 1 
ATOM   1339 C  CG2 . ILE A 1 176 ? -21.672 -21.018 12.971  1.00 19.17 ? 398  ILE A CG2 1 
ATOM   1340 C  CD1 . ILE A 1 176 ? -19.774 -21.980 15.232  1.00 19.44 ? 398  ILE A CD1 1 
ATOM   1341 N  N   . GLN A 1 177 ? -21.634 -25.074 11.352  1.00 15.30 ? 399  GLN A N   1 
ATOM   1342 C  CA  . GLN A 1 177 ? -21.149 -26.392 10.974  1.00 15.85 ? 399  GLN A CA  1 
ATOM   1343 C  C   . GLN A 1 177 ? -19.889 -26.247 10.142  1.00 14.30 ? 399  GLN A C   1 
ATOM   1344 O  O   . GLN A 1 177 ? -19.852 -25.444 9.205   1.00 14.33 ? 399  GLN A O   1 
ATOM   1345 C  CB  . GLN A 1 177 ? -22.203 -27.159 10.177  1.00 14.87 ? 399  GLN A CB  1 
ATOM   1346 C  CG  . GLN A 1 177 ? -21.734 -28.536 9.734   1.00 10.56 ? 399  GLN A CG  1 
ATOM   1347 C  CD  . GLN A 1 177 ? -22.850 -29.297 9.051   1.00 13.56 ? 399  GLN A CD  1 
ATOM   1348 O  OE1 . GLN A 1 177 ? -22.998 -29.228 7.836   1.00 16.61 ? 399  GLN A OE1 1 
ATOM   1349 N  NE2 . GLN A 1 177 ? -23.669 -29.998 9.838   1.00 13.36 ? 399  GLN A NE2 1 
ATOM   1350 N  N   . PHE A 1 178 ? -18.871 -27.037 10.480  1.00 13.03 ? 400  PHE A N   1 
ATOM   1351 C  CA  . PHE A 1 178 ? -17.635 -27.101 9.715   1.00 12.97 ? 400  PHE A CA  1 
ATOM   1352 C  C   . PHE A 1 178 ? -17.754 -28.191 8.662   1.00 12.39 ? 400  PHE A C   1 
ATOM   1353 O  O   . PHE A 1 178 ? -18.080 -29.335 8.992   1.00 14.65 ? 400  PHE A O   1 
ATOM   1354 C  CB  . PHE A 1 178 ? -16.445 -27.404 10.630  1.00 14.41 ? 400  PHE A CB  1 
ATOM   1355 C  CG  . PHE A 1 178 ? -15.168 -27.656 9.878   1.00 13.81 ? 400  PHE A CG  1 
ATOM   1356 C  CD1 . PHE A 1 178 ? -14.491 -26.607 9.267   1.00 16.80 ? 400  PHE A CD1 1 
ATOM   1357 C  CD2 . PHE A 1 178 ? -14.663 -28.940 9.757   1.00 16.24 ? 400  PHE A CD2 1 
ATOM   1358 C  CE1 . PHE A 1 178 ? -13.321 -26.840 8.553   1.00 16.76 ? 400  PHE A CE1 1 
ATOM   1359 C  CE2 . PHE A 1 178 ? -13.493 -29.177 9.044   1.00 13.96 ? 400  PHE A CE2 1 
ATOM   1360 C  CZ  . PHE A 1 178 ? -12.825 -28.135 8.449   1.00 16.24 ? 400  PHE A CZ  1 
ATOM   1361 N  N   . SER A 1 179 ? -17.472 -27.840 7.406   1.00 11.41 ? 401  SER A N   1 
ATOM   1362 C  CA  . SER A 1 179 ? -17.514 -28.794 6.304   1.00 12.64 ? 401  SER A CA  1 
ATOM   1363 C  C   . SER A 1 179 ? -16.136 -28.869 5.658   1.00 12.03 ? 401  SER A C   1 
ATOM   1364 O  O   . SER A 1 179 ? -15.643 -27.848 5.147   1.00 12.48 ? 401  SER A O   1 
ATOM   1365 C  CB  . SER A 1 179 ? -18.567 -28.381 5.275   1.00 15.02 ? 401  SER A CB  1 
ATOM   1366 O  OG  . SER A 1 179 ? -18.562 -29.269 4.168   1.00 15.24 ? 401  SER A OG  1 
ATOM   1367 N  N   . PRO A 1 180 ? -15.483 -30.027 5.655   1.00 13.46 ? 402  PRO A N   1 
ATOM   1368 C  CA  . PRO A 1 180 ? -14.106 -30.104 5.152   1.00 12.97 ? 402  PRO A CA  1 
ATOM   1369 C  C   . PRO A 1 180 ? -14.021 -30.228 3.638   1.00 17.10 ? 402  PRO A C   1 
ATOM   1370 O  O   . PRO A 1 180 ? -14.864 -30.850 2.984   1.00 12.92 ? 402  PRO A O   1 
ATOM   1371 C  CB  . PRO A 1 180 ? -13.576 -31.383 5.805   1.00 15.22 ? 402  PRO A CB  1 
ATOM   1372 C  CG  . PRO A 1 180 ? -14.783 -32.243 5.919   1.00 14.87 ? 402  PRO A CG  1 
ATOM   1373 C  CD  . PRO A 1 180 ? -15.904 -31.282 6.302   1.00 13.58 ? 402  PRO A CD  1 
ATOM   1374 N  N   . THR A 1 181 ? -12.965 -29.634 3.091   1.00 14.05 ? 403  THR A N   1 
ATOM   1375 C  CA  A THR A 1 181 ? -12.620 -29.821 1.688   0.96 11.44 ? 403  THR A CA  1 
ATOM   1376 C  CA  B THR A 1 181 ? -12.610 -29.802 1.692   0.04 11.81 ? 403  THR A CA  1 
ATOM   1377 C  C   . THR A 1 181 ? -11.386 -30.680 1.488   1.00 13.12 ? 403  THR A C   1 
ATOM   1378 O  O   . THR A 1 181 ? -11.256 -31.304 0.437   1.00 16.74 ? 403  THR A O   1 
ATOM   1379 C  CB  A THR A 1 181 ? -12.377 -28.479 0.975   0.96 15.92 ? 403  THR A CB  1 
ATOM   1380 C  CB  B THR A 1 181 ? -12.357 -28.432 1.049   0.04 15.93 ? 403  THR A CB  1 
ATOM   1381 O  OG1 A THR A 1 181 ? -11.377 -27.723 1.678   0.96 18.41 ? 403  THR A OG1 1 
ATOM   1382 O  OG1 B THR A 1 181 ? -13.185 -27.450 1.684   0.04 17.20 ? 403  THR A OG1 1 
ATOM   1383 C  CG2 A THR A 1 181 ? -13.664 -27.669 0.866   0.96 18.94 ? 403  THR A CG2 1 
ATOM   1384 C  CG2 B THR A 1 181 ? -12.698 -28.470 -0.420  0.04 16.26 ? 403  THR A CG2 1 
ATOM   1385 N  N   . GLY A 1 182 ? -10.490 -30.738 2.468   1.00 13.57 ? 404  GLY A N   1 
ATOM   1386 C  CA  . GLY A 1 182 ? -9.230  -31.432 2.286   1.00 13.90 ? 404  GLY A CA  1 
ATOM   1387 C  C   . GLY A 1 182 ? -8.301  -31.132 3.445   1.00 14.98 ? 404  GLY A C   1 
ATOM   1388 O  O   . GLY A 1 182 ? -8.733  -30.637 4.485   1.00 15.90 ? 404  GLY A O   1 
ATOM   1389 N  N   . ILE A 1 183 ? -7.016  -31.452 3.259   1.00 14.51 ? 405  ILE A N   1 
ATOM   1390 C  CA  . ILE A 1 183 ? -6.050  -31.255 4.336   1.00 13.02 ? 405  ILE A CA  1 
ATOM   1391 C  C   . ILE A 1 183 ? -4.813  -30.536 3.820   1.00 14.57 ? 405  ILE A C   1 
ATOM   1392 O  O   . ILE A 1 183 ? -4.539  -30.485 2.619   1.00 14.98 ? 405  ILE A O   1 
ATOM   1393 C  CB  . ILE A 1 183 ? -5.608  -32.578 5.003   1.00 14.03 ? 405  ILE A CB  1 
ATOM   1394 C  CG1 . ILE A 1 183 ? -4.859  -33.456 3.986   1.00 15.85 ? 405  ILE A CG1 1 
ATOM   1395 C  CG2 . ILE A 1 183 ? -6.810  -33.324 5.611   1.00 14.35 ? 405  ILE A CG2 1 
ATOM   1396 C  CD1 . ILE A 1 183 ? -4.190  -34.675 4.620   1.00 17.92 ? 405  ILE A CD1 1 
ATOM   1397 N  N   . GLU A 1 184 ? -4.062  -29.978 4.759   1.00 16.92 ? 406  GLU A N   1 
ATOM   1398 C  CA  . GLU A 1 184 ? -2.638  -29.782 4.559   1.00 16.16 ? 406  GLU A CA  1 
ATOM   1399 C  C   . GLU A 1 184 ? -1.941  -31.068 4.963   1.00 16.94 ? 406  GLU A C   1 
ATOM   1400 O  O   . GLU A 1 184 ? -2.391  -31.779 5.862   1.00 20.43 ? 406  GLU A O   1 
ATOM   1401 C  CB  . GLU A 1 184 ? -2.105  -28.602 5.383   1.00 20.73 ? 406  GLU A CB  1 
ATOM   1402 C  CG  . GLU A 1 184 ? -2.666  -27.253 4.951   1.00 22.18 ? 406  GLU A CG  1 
ATOM   1403 C  CD  . GLU A 1 184 ? -1.990  -26.079 5.646   1.00 34.44 ? 406  GLU A CD  1 
ATOM   1404 O  OE1 . GLU A 1 184 ? -0.997  -26.299 6.371   1.00 27.71 ? 406  GLU A OE1 1 
ATOM   1405 O  OE2 . GLU A 1 184 ? -2.455  -24.934 5.462   1.00 28.26 ? 406  GLU A OE2 1 
ATOM   1406 N  N   . SER A 1 185 ? -0.844  -31.374 4.284   1.00 18.40 ? 407  SER A N   1 
ATOM   1407 C  CA  A SER A 1 185 ? -0.090  -32.593 4.542   0.60 19.10 ? 407  SER A CA  1 
ATOM   1408 C  CA  B SER A 1 185 ? -0.092  -32.595 4.534   0.40 19.13 ? 407  SER A CA  1 
ATOM   1409 C  C   . SER A 1 185 ? 1.384   -32.248 4.661   1.00 23.30 ? 407  SER A C   1 
ATOM   1410 O  O   . SER A 1 185 ? 1.911   -31.487 3.847   1.00 27.89 ? 407  SER A O   1 
ATOM   1411 C  CB  A SER A 1 185 ? -0.288  -33.611 3.424   0.60 19.00 ? 407  SER A CB  1 
ATOM   1412 C  CB  B SER A 1 185 ? -0.320  -33.606 3.404   0.40 19.05 ? 407  SER A CB  1 
ATOM   1413 O  OG  A SER A 1 185 ? 0.310   -33.124 2.238   0.60 19.81 ? 407  SER A OG  1 
ATOM   1414 O  OG  B SER A 1 185 ? 0.091   -34.910 3.767   0.40 15.94 ? 407  SER A OG  1 
ATOM   1415 N  N   . ASP A 1 186 ? 2.045   -32.804 5.678   1.00 23.89 ? 408  ASP A N   1 
ATOM   1416 C  CA  . ASP A 1 186 ? 3.481   -32.593 5.835   1.00 31.47 ? 408  ASP A CA  1 
ATOM   1417 C  C   . ASP A 1 186 ? 4.193   -33.911 6.109   1.00 39.58 ? 408  ASP A C   1 
ATOM   1418 O  O   . ASP A 1 186 ? 3.593   -34.986 5.997   1.00 25.68 ? 408  ASP A O   1 
ATOM   1419 C  CB  . ASP A 1 186 ? 3.785   -31.575 6.943   1.00 29.02 ? 408  ASP A CB  1 
ATOM   1420 C  CG  . ASP A 1 186 ? 3.206   -31.961 8.299   1.00 33.74 ? 408  ASP A CG  1 
ATOM   1421 O  OD1 . ASP A 1 186 ? 3.238   -33.153 8.670   1.00 30.10 ? 408  ASP A OD1 1 
ATOM   1422 O  OD2 . ASP A 1 186 ? 2.747   -31.049 9.021   1.00 38.40 ? 408  ASP A OD2 1 
ATOM   1423 N  N   . GLN A 1 187 ? 5.472   -33.827 6.478   1.00 39.26 ? 409  GLN A N   1 
ATOM   1424 C  CA  A GLN A 1 187 ? 6.287   -35.020 6.684   0.49 39.83 ? 409  GLN A CA  1 
ATOM   1425 C  CA  B GLN A 1 187 ? 6.270   -35.035 6.669   0.51 39.81 ? 409  GLN A CA  1 
ATOM   1426 C  C   . GLN A 1 187 ? 5.747   -35.898 7.806   1.00 33.11 ? 409  GLN A C   1 
ATOM   1427 O  O   . GLN A 1 187 ? 6.001   -37.107 7.820   1.00 39.26 ? 409  GLN A O   1 
ATOM   1428 C  CB  A GLN A 1 187 ? 7.736   -34.610 6.973   0.49 36.00 ? 409  GLN A CB  1 
ATOM   1429 C  CB  B GLN A 1 187 ? 7.741   -34.674 6.919   0.51 36.00 ? 409  GLN A CB  1 
ATOM   1430 C  CG  A GLN A 1 187 ? 7.904   -33.638 8.147   0.49 36.21 ? 409  GLN A CG  1 
ATOM   1431 C  CG  B GLN A 1 187 ? 7.998   -33.943 8.230   0.51 36.04 ? 409  GLN A CG  1 
ATOM   1432 C  CD  A GLN A 1 187 ? 7.450   -32.214 7.835   0.49 41.50 ? 409  GLN A CD  1 
ATOM   1433 C  CD  B GLN A 1 187 ? 9.471   -33.639 8.458   0.51 41.13 ? 409  GLN A CD  1 
ATOM   1434 O  OE1 A GLN A 1 187 ? 7.285   -31.835 6.671   0.49 34.14 ? 409  GLN A OE1 1 
ATOM   1435 O  OE1 B GLN A 1 187 ? 10.318  -33.939 7.615   0.51 45.53 ? 409  GLN A OE1 1 
ATOM   1436 N  NE2 A GLN A 1 187 ? 7.235   -31.423 8.881   0.49 45.04 ? 409  GLN A NE2 1 
ATOM   1437 N  NE2 B GLN A 1 187 ? 9.781   -33.043 9.604   0.51 42.99 ? 409  GLN A NE2 1 
ATOM   1438 N  N   . ASN A 1 188 ? 5.013   -35.318 8.748   1.00 28.71 ? 410  ASN A N   1 
ATOM   1439 C  CA  . ASN A 1 188 ? 4.479   -36.065 9.875   1.00 27.67 ? 410  ASN A CA  1 
ATOM   1440 C  C   . ASN A 1 188 ? 3.063   -36.576 9.652   1.00 23.81 ? 410  ASN A C   1 
ATOM   1441 O  O   . ASN A 1 188 ? 2.527   -37.245 10.539  1.00 28.78 ? 410  ASN A O   1 
ATOM   1442 C  CB  . ASN A 1 188 ? 4.506   -35.199 11.136  1.00 32.00 ? 410  ASN A CB  1 
ATOM   1443 C  CG  . ASN A 1 188 ? 5.898   -34.738 11.484  1.00 49.07 ? 410  ASN A CG  1 
ATOM   1444 O  OD1 . ASN A 1 188 ? 6.860   -35.499 11.365  1.00 43.59 ? 410  ASN A OD1 1 
ATOM   1445 N  ND2 . ASN A 1 188 ? 6.021   -33.478 11.897  1.00 32.94 ? 410  ASN A ND2 1 
ATOM   1446 N  N   . THR A 1 189 ? 2.442   -36.276 8.510   1.00 26.45 ? 411  THR A N   1 
ATOM   1447 C  CA  . THR A 1 189 ? 1.055   -36.676 8.313   1.00 20.62 ? 411  THR A CA  1 
ATOM   1448 C  C   . THR A 1 189 ? 0.946   -38.193 8.282   1.00 19.92 ? 411  THR A C   1 
ATOM   1449 O  O   . THR A 1 189 ? 1.667   -38.868 7.547   1.00 17.57 ? 411  THR A O   1 
ATOM   1450 C  CB  . THR A 1 189 ? 0.495   -36.073 7.025   1.00 19.29 ? 411  THR A CB  1 
ATOM   1451 O  OG1 . THR A 1 189 ? 0.442   -34.650 7.159   1.00 22.95 ? 411  THR A OG1 1 
ATOM   1452 C  CG2 . THR A 1 189 ? -0.927  -36.596 6.768   1.00 20.86 ? 411  THR A CG2 1 
ATOM   1453 N  N   . ASP A 1 190 ? 0.044   -38.722 9.101   1.00 19.53 ? 412  ASP A N   1 
ATOM   1454 C  CA  . ASP A 1 190 ? -0.202  -40.157 9.185   1.00 21.13 ? 412  ASP A CA  1 
ATOM   1455 C  C   . ASP A 1 190 ? -1.680  -40.286 9.539   1.00 18.91 ? 412  ASP A C   1 
ATOM   1456 O  O   . ASP A 1 190 ? -2.056  -40.079 10.695  1.00 20.35 ? 412  ASP A O   1 
ATOM   1457 C  CB  . ASP A 1 190 ? 0.698   -40.806 10.230  1.00 22.56 ? 412  ASP A CB  1 
ATOM   1458 C  CG  . ASP A 1 190 ? 0.436   -42.292 10.402  1.00 29.62 ? 412  ASP A CG  1 
ATOM   1459 O  OD1 . ASP A 1 190 ? -0.498  -42.828 9.774   1.00 23.38 ? 412  ASP A OD1 1 
ATOM   1460 O  OD2 . ASP A 1 190 ? 1.175   -42.934 11.176  1.00 25.55 ? 412  ASP A OD2 1 
ATOM   1461 N  N   . LEU A 1 191 ? -2.508  -40.576 8.540   1.00 15.97 ? 413  LEU A N   1 
ATOM   1462 C  CA  . LEU A 1 191 ? -3.947  -40.601 8.762   1.00 14.22 ? 413  LEU A CA  1 
ATOM   1463 C  C   . LEU A 1 191 ? -4.412  -41.902 9.404   1.00 14.52 ? 413  LEU A C   1 
ATOM   1464 O  O   . LEU A 1 191 ? -5.614  -42.075 9.631   1.00 16.54 ? 413  LEU A O   1 
ATOM   1465 C  CB  . LEU A 1 191 ? -4.686  -40.354 7.437   1.00 11.85 ? 413  LEU A CB  1 
ATOM   1466 C  CG  . LEU A 1 191 ? -4.316  -39.058 6.696   1.00 11.49 ? 413  LEU A CG  1 
ATOM   1467 C  CD1 . LEU A 1 191 ? -5.190  -38.895 5.451   1.00 15.08 ? 413  LEU A CD1 1 
ATOM   1468 C  CD2 . LEU A 1 191 ? -4.404  -37.814 7.598   1.00 12.85 ? 413  LEU A CD2 1 
ATOM   1469 N  N   . ASN A 1 192 ? -3.495  -42.813 9.720   1.00 15.21 ? 414  ASN A N   1 
ATOM   1470 C  CA  . ASN A 1 192 ? -3.850  -44.039 10.411  1.00 17.63 ? 414  ASN A CA  1 
ATOM   1471 C  C   . ASN A 1 192 ? -3.658  -43.934 11.921  1.00 19.95 ? 414  ASN A C   1 
ATOM   1472 O  O   . ASN A 1 192 ? -3.597  -44.960 12.603  1.00 20.94 ? 414  ASN A O   1 
ATOM   1473 C  CB  . ASN A 1 192 ? -3.048  -45.208 9.848   1.00 14.48 ? 414  ASN A CB  1 
ATOM   1474 C  CG  . ASN A 1 192 ? -3.427  -45.524 8.424   1.00 17.17 ? 414  ASN A CG  1 
ATOM   1475 O  OD1 . ASN A 1 192 ? -4.607  -45.653 8.104   1.00 19.50 ? 414  ASN A OD1 1 
ATOM   1476 N  ND2 . ASN A 1 192 ? -2.429  -45.624 7.550   1.00 15.43 ? 414  ASN A ND2 1 
ATOM   1477 N  N   . GLN A 1 193 ? -3.571  -42.720 12.457  1.00 14.49 ? 415  GLN A N   1 
ATOM   1478 C  CA  . GLN A 1 193 ? -3.505  -42.508 13.898  1.00 15.41 ? 415  GLN A CA  1 
ATOM   1479 C  C   . GLN A 1 193 ? -4.715  -41.710 14.348  1.00 20.77 ? 415  GLN A C   1 
ATOM   1480 O  O   . GLN A 1 193 ? -5.001  -40.647 13.786  1.00 21.20 ? 415  GLN A O   1 
ATOM   1481 C  CB  . GLN A 1 193 ? -2.238  -41.761 14.301  1.00 18.68 ? 415  GLN A CB  1 
ATOM   1482 C  CG  . GLN A 1 193 ? -0.960  -42.457 13.886  1.00 26.78 ? 415  GLN A CG  1 
ATOM   1483 C  CD  . GLN A 1 193 ? 0.263   -41.701 14.352  1.00 37.31 ? 415  GLN A CD  1 
ATOM   1484 O  OE1 . GLN A 1 193 ? 0.152   -40.703 15.065  1.00 49.19 ? 415  GLN A OE1 1 
ATOM   1485 N  NE2 . GLN A 1 193 ? 1.436   -42.169 13.951  1.00 37.91 ? 415  GLN A NE2 1 
ATOM   1486 N  N   . LEU A 1 194 ? -5.404  -42.208 15.373  1.00 16.43 ? 416  LEU A N   1 
ATOM   1487 C  CA  . LEU A 1 194 ? -6.571  -41.510 15.882  1.00 13.37 ? 416  LEU A CA  1 
ATOM   1488 C  C   . LEU A 1 194 ? -6.160  -40.215 16.571  1.00 16.82 ? 416  LEU A C   1 
ATOM   1489 O  O   . LEU A 1 194 ? -5.081  -40.134 17.166  1.00 17.15 ? 416  LEU A O   1 
ATOM   1490 C  CB  . LEU A 1 194 ? -7.320  -42.378 16.877  1.00 14.29 ? 416  LEU A CB  1 
ATOM   1491 C  CG  . LEU A 1 194 ? -8.099  -43.579 16.364  1.00 13.84 ? 416  LEU A CG  1 
ATOM   1492 C  CD1 . LEU A 1 194 ? -8.749  -44.232 17.546  1.00 13.33 ? 416  LEU A CD1 1 
ATOM   1493 C  CD2 . LEU A 1 194 ? -9.149  -43.125 15.337  1.00 11.76 ? 416  LEU A CD2 1 
ATOM   1494 N  N   . PRO A 1 195 ? -7.009  -39.194 16.530  1.00 16.09 ? 417  PRO A N   1 
ATOM   1495 C  CA  . PRO A 1 195 ? -6.753  -38.007 17.345  1.00 16.00 ? 417  PRO A CA  1 
ATOM   1496 C  C   . PRO A 1 195 ? -7.000  -38.323 18.811  1.00 16.51 ? 417  PRO A C   1 
ATOM   1497 O  O   . PRO A 1 195 ? -7.570  -39.353 19.168  1.00 16.50 ? 417  PRO A O   1 
ATOM   1498 C  CB  . PRO A 1 195 ? -7.740  -36.969 16.805  1.00 16.48 ? 417  PRO A CB  1 
ATOM   1499 C  CG  . PRO A 1 195 ? -8.835  -37.759 16.173  1.00 17.45 ? 417  PRO A CG  1 
ATOM   1500 C  CD  . PRO A 1 195 ? -8.227  -39.066 15.708  1.00 14.72 ? 417  PRO A CD  1 
ATOM   1501 N  N   . ASP A 1 196 ? -6.541  -37.419 19.670  1.00 16.46 ? 418  ASP A N   1 
ATOM   1502 C  CA  . ASP A 1 196 ? -6.794  -37.528 21.107  1.00 16.92 ? 418  ASP A CA  1 
ATOM   1503 C  C   . ASP A 1 196 ? -8.122  -36.830 21.365  1.00 17.33 ? 418  ASP A C   1 
ATOM   1504 O  O   . ASP A 1 196 ? -8.190  -35.611 21.519  1.00 18.64 ? 418  ASP A O   1 
ATOM   1505 C  CB  . ASP A 1 196 ? -5.656  -36.908 21.908  1.00 21.70 ? 418  ASP A CB  1 
ATOM   1506 C  CG  . ASP A 1 196 ? -4.328  -37.603 21.671  1.00 28.54 ? 418  ASP A CG  1 
ATOM   1507 O  OD1 . ASP A 1 196 ? -4.311  -38.850 21.604  1.00 27.02 ? 418  ASP A OD1 1 
ATOM   1508 O  OD2 . ASP A 1 196 ? -3.298  -36.902 21.543  1.00 33.70 ? 418  ASP A OD2 1 
ATOM   1509 N  N   . TYR A 1 197 ? -9.199  -37.620 21.382  1.00 14.15 ? 419  TYR A N   1 
ATOM   1510 C  CA  . TYR A 1 197 ? -10.538 -37.046 21.449  1.00 14.58 ? 419  TYR A CA  1 
ATOM   1511 C  C   . TYR A 1 197 ? -10.769 -36.264 22.733  1.00 16.75 ? 419  TYR A C   1 
ATOM   1512 O  O   . TYR A 1 197 ? -11.603 -35.359 22.757  1.00 14.19 ? 419  TYR A O   1 
ATOM   1513 C  CB  . TYR A 1 197 ? -11.586 -38.146 21.339  1.00 14.11 ? 419  TYR A CB  1 
ATOM   1514 C  CG  . TYR A 1 197 ? -11.646 -38.791 19.966  1.00 14.24 ? 419  TYR A CG  1 
ATOM   1515 C  CD1 . TYR A 1 197 ? -12.260 -38.137 18.899  1.00 13.92 ? 419  TYR A CD1 1 
ATOM   1516 C  CD2 . TYR A 1 197 ? -11.127 -40.064 19.753  1.00 14.71 ? 419  TYR A CD2 1 
ATOM   1517 C  CE1 . TYR A 1 197 ? -12.332 -38.737 17.630  1.00 14.98 ? 419  TYR A CE1 1 
ATOM   1518 C  CE2 . TYR A 1 197 ? -11.188 -40.666 18.487  1.00 15.74 ? 419  TYR A CE2 1 
ATOM   1519 C  CZ  . TYR A 1 197 ? -11.799 -40.005 17.442  1.00 17.04 ? 419  TYR A CZ  1 
ATOM   1520 O  OH  . TYR A 1 197 ? -11.874 -40.614 16.201  1.00 14.02 ? 419  TYR A OH  1 
ATOM   1521 N  N   . GLY A 1 198 ? -10.091 -36.633 23.810  1.00 19.78 ? 420  GLY A N   1 
ATOM   1522 C  CA  . GLY A 1 198 ? -10.231 -35.924 25.066  1.00 21.76 ? 420  GLY A CA  1 
ATOM   1523 C  C   . GLY A 1 198 ? -9.175  -34.869 25.291  1.00 24.01 ? 420  GLY A C   1 
ATOM   1524 O  O   . GLY A 1 198 ? -9.105  -34.298 26.385  1.00 28.37 ? 420  GLY A O   1 
ATOM   1525 N  N   . GLY A 1 199 ? -8.348  -34.598 24.287  1.00 19.09 ? 421  GLY A N   1 
ATOM   1526 C  CA  . GLY A 1 199 ? -7.260  -33.646 24.455  1.00 22.79 ? 421  GLY A CA  1 
ATOM   1527 C  C   . GLY A 1 199 ? -6.171  -34.247 25.321  1.00 24.95 ? 421  GLY A C   1 
ATOM   1528 O  O   . GLY A 1 199 ? -5.731  -35.383 25.108  1.00 28.06 ? 421  GLY A O   1 
ATOM   1529 N  N   . ALA A 1 200 ? -5.721  -33.486 26.322  1.00 29.62 ? 422  ALA A N   1 
ATOM   1530 C  CA  . ALA A 1 200 ? -4.726  -34.026 27.241  1.00 43.88 ? 422  ALA A CA  1 
ATOM   1531 C  C   . ALA A 1 200 ? -5.267  -35.204 28.046  1.00 43.96 ? 422  ALA A C   1 
ATOM   1532 O  O   . ALA A 1 200 ? -4.481  -36.032 28.519  1.00 42.90 ? 422  ALA A O   1 
ATOM   1533 C  CB  . ALA A 1 200 ? -4.224  -32.925 28.175  1.00 48.96 ? 422  ALA A CB  1 
ATOM   1534 N  N   . MET A 1 201 ? -6.588  -35.313 28.185  1.00 51.84 ? 423  MET A N   1 
ATOM   1535 C  CA  . MET A 1 201 ? -7.225  -36.396 28.930  1.00 36.69 ? 423  MET A CA  1 
ATOM   1536 C  C   . MET A 1 201 ? -7.449  -37.609 28.030  1.00 55.24 ? 423  MET A C   1 
ATOM   1537 O  O   . MET A 1 201 ? -8.149  -37.520 27.015  1.00 37.29 ? 423  MET A O   1 
ATOM   1538 C  CB  . MET A 1 201 ? -8.554  -35.925 29.511  1.00 37.49 ? 423  MET A CB  1 
ATOM   1539 C  CG  . MET A 1 201 ? -9.442  -37.049 30.003  1.00 44.59 ? 423  MET A CG  1 
ATOM   1540 S  SD  . MET A 1 201 ? -11.113 -36.477 30.365  1.00 68.75 ? 423  MET A SD  1 
ATOM   1541 C  CE  . MET A 1 201 ? -11.599 -35.835 28.768  1.00 47.07 ? 423  MET A CE  1 
ATOM   1542 N  N   A THR A 1 202 ? -6.751  -38.702 28.331  0.40 44.73 ? 424  THR A N   1 
ATOM   1543 N  N   B THR A 1 202 ? -6.974  -38.769 28.483  0.60 44.04 ? 424  THR A N   1 
ATOM   1544 C  CA  A THR A 1 202 ? -6.866  -39.902 27.516  0.40 46.23 ? 424  THR A CA  1 
ATOM   1545 C  CA  B THR A 1 202 ? -7.223  -40.024 27.782  0.60 44.76 ? 424  THR A CA  1 
ATOM   1546 C  C   A THR A 1 202 ? -8.162  -40.649 27.777  0.40 41.48 ? 424  THR A C   1 
ATOM   1547 C  C   B THR A 1 202 ? -8.718  -40.311 27.649  0.60 39.71 ? 424  THR A C   1 
ATOM   1548 O  O   A THR A 1 202 ? -8.527  -41.529 26.989  0.40 47.89 ? 424  THR A O   1 
ATOM   1549 O  O   B THR A 1 202 ? -9.530  -39.912 28.488  0.60 40.52 ? 424  THR A O   1 
ATOM   1550 C  CB  A THR A 1 202 ? -5.668  -40.827 27.757  0.40 47.66 ? 424  THR A CB  1 
ATOM   1551 C  CB  B THR A 1 202 ? -6.555  -41.186 28.518  0.60 47.91 ? 424  THR A CB  1 
ATOM   1552 O  OG1 A THR A 1 202 ? -6.031  -42.179 27.446  0.40 52.01 ? 424  THR A OG1 1 
ATOM   1553 O  OG1 B THR A 1 202 ? -7.067  -42.428 28.015  0.60 49.47 ? 424  THR A OG1 1 
ATOM   1554 C  CG2 A THR A 1 202 ? -5.202  -40.739 29.202  0.40 45.74 ? 424  THR A CG2 1 
ATOM   1555 C  CG2 B THR A 1 202 ? -6.834  -41.096 30.014  0.60 48.38 ? 424  THR A CG2 1 
ATOM   1556 N  N   A VAL A 1 203 ? -8.866  -40.307 28.852  0.40 44.98 ? 425  VAL A N   1 
ATOM   1557 N  N   B VAL A 1 203 ? -9.078  -41.016 26.573  0.60 37.51 ? 425  VAL A N   1 
ATOM   1558 C  CA  A VAL A 1 203 ? -10.151 -40.910 29.169  0.40 44.18 ? 425  VAL A CA  1 
ATOM   1559 C  CA  B VAL A 1 203 ? -10.439 -41.489 26.344  0.60 28.72 ? 425  VAL A CA  1 
ATOM   1560 C  C   A VAL A 1 203 ? -11.152 -40.531 28.088  0.40 34.36 ? 425  VAL A C   1 
ATOM   1561 C  C   B VAL A 1 203 ? -10.381 -42.943 25.891  0.60 39.30 ? 425  VAL A C   1 
ATOM   1562 O  O   A VAL A 1 203 ? -11.922 -39.581 28.249  0.40 42.02 ? 425  VAL A O   1 
ATOM   1563 O  O   B VAL A 1 203 ? -9.535  -43.316 25.069  0.60 34.09 ? 425  VAL A O   1 
ATOM   1564 C  CB  A VAL A 1 203 ? -10.646 -40.469 30.559  0.40 44.96 ? 425  VAL A CB  1 
ATOM   1565 C  CB  B VAL A 1 203 ? -11.187 -40.632 25.301  0.60 31.06 ? 425  VAL A CB  1 
ATOM   1566 C  CG1 A VAL A 1 203 ? -11.868 -41.276 30.966  0.40 49.37 ? 425  VAL A CG1 1 
ATOM   1567 C  CG1 B VAL A 1 203 ? -12.627 -41.098 25.160  0.60 26.94 ? 425  VAL A CG1 1 
ATOM   1568 C  CG2 A VAL A 1 203 ? -9.533  -40.599 31.590  0.40 41.94 ? 425  VAL A CG2 1 
ATOM   1569 C  CG2 B VAL A 1 203 ? -11.145 -39.182 25.685  0.60 32.55 ? 425  VAL A CG2 1 
ATOM   1570 N  N   A SER A 1 204 ? -11.117 -41.243 26.968  0.40 36.17 ? 426  SER A N   1 
ATOM   1571 N  N   B SER A 1 204 ? -11.284 -43.764 26.425  0.60 33.21 ? 426  SER A N   1 
ATOM   1572 C  CA  A SER A 1 204 ? -12.175 -41.213 25.971  0.40 25.77 ? 426  SER A CA  1 
ATOM   1573 C  CA  B SER A 1 204 ? -11.321 -45.180 26.079  0.60 25.77 ? 426  SER A CA  1 
ATOM   1574 C  C   A SER A 1 204 ? -12.783 -42.603 25.900  0.40 23.13 ? 426  SER A C   1 
ATOM   1575 C  C   B SER A 1 204 ? -12.749 -45.602 25.760  0.60 37.76 ? 426  SER A C   1 
ATOM   1576 O  O   A SER A 1 204 ? -12.065 -43.604 25.973  0.40 27.59 ? 426  SER A O   1 
ATOM   1577 O  O   B SER A 1 204 ? -12.982 -46.454 24.889  0.60 25.48 ? 426  SER A O   1 
ATOM   1578 C  CB  A SER A 1 204 ? -11.649 -40.781 24.598  0.40 31.05 ? 426  SER A CB  1 
ATOM   1579 C  CB  B SER A 1 204 ? -10.750 -46.028 27.220  0.60 37.24 ? 426  SER A CB  1 
ATOM   1580 O  OG  A SER A 1 204 ? -12.419 -41.346 23.553  0.40 20.78 ? 426  SER A OG  1 
ATOM   1581 O  OG  B SER A 1 204 ? -11.415 -45.760 28.448  0.60 28.85 ? 426  SER A OG  1 
ATOM   1582 N  N   A LYS A 1 205 ? -14.106 -42.669 25.786  0.40 18.69 ? 427  LYS A N   1 
ATOM   1583 N  N   B LYS A 1 205 ? -13.706 -44.973 26.443  0.60 25.70 ? 427  LYS A N   1 
ATOM   1584 C  CA  A LYS A 1 205 ? -14.815 -43.935 25.874  0.40 18.90 ? 427  LYS A CA  1 
ATOM   1585 C  CA  B LYS A 1 205 ? -15.095 -45.403 26.379  0.60 26.53 ? 427  LYS A CA  1 
ATOM   1586 C  C   A LYS A 1 205 ? -15.698 -44.132 24.649  0.40 21.27 ? 427  LYS A C   1 
ATOM   1587 C  C   B LYS A 1 205 ? -15.684 -45.171 24.995  0.60 17.22 ? 427  LYS A C   1 
ATOM   1588 O  O   A LYS A 1 205 ? -15.985 -43.194 23.902  0.40 16.40 ? 427  LYS A O   1 
ATOM   1589 O  O   B LYS A 1 205 ? -15.531 -44.095 24.410  0.60 21.85 ? 427  LYS A O   1 
ATOM   1590 C  CB  A LYS A 1 205 ? -15.661 -44.012 27.149  0.40 21.27 ? 427  LYS A CB  1 
ATOM   1591 C  CB  B LYS A 1 205 ? -15.923 -44.666 27.430  0.60 24.44 ? 427  LYS A CB  1 
ATOM   1592 C  CG  A LYS A 1 205 ? -14.871 -43.774 28.427  0.40 27.37 ? 427  LYS A CG  1 
ATOM   1593 C  CG  B LYS A 1 205 ? -15.402 -44.858 28.849  0.60 32.78 ? 427  LYS A CG  1 
ATOM   1594 C  CD  A LYS A 1 205 ? -15.739 -44.017 29.649  0.40 36.17 ? 427  LYS A CD  1 
ATOM   1595 C  CD  B LYS A 1 205 ? -16.259 -44.120 29.861  0.60 36.62 ? 427  LYS A CD  1 
ATOM   1596 C  CE  A LYS A 1 205 ? -15.129 -43.399 30.893  0.40 40.06 ? 427  LYS A CE  1 
ATOM   1597 C  CE  B LYS A 1 205 ? -15.548 -43.998 31.197  0.60 44.50 ? 427  LYS A CE  1 
ATOM   1598 N  NZ  A LYS A 1 205 ? -15.104 -41.912 30.809  0.40 34.85 ? 427  LYS A NZ  1 
ATOM   1599 N  NZ  B LYS A 1 205 ? -14.277 -43.237 31.050  0.60 44.73 ? 427  LYS A NZ  1 
ATOM   1600 N  N   A GLY A 1 206 ? -16.128 -45.375 24.455  0.40 17.66 ? 428  GLY A N   1 
ATOM   1601 N  N   B GLY A 1 206 ? -16.376 -46.181 24.485  0.60 19.55 ? 428  GLY A N   1 
ATOM   1602 C  CA  A GLY A 1 206 ? -16.976 -45.710 23.330  0.40 19.37 ? 428  GLY A CA  1 
ATOM   1603 C  CA  B GLY A 1 206 ? -17.100 -46.043 23.249  0.60 20.17 ? 428  GLY A CA  1 
ATOM   1604 C  C   A GLY A 1 206 ? -16.242 -45.975 22.038  0.40 18.10 ? 428  GLY A C   1 
ATOM   1605 C  C   B GLY A 1 206 ? -16.267 -46.130 21.994  0.60 17.97 ? 428  GLY A C   1 
ATOM   1606 O  O   A GLY A 1 206 ? -16.860 -45.933 20.970  0.40 17.32 ? 428  GLY A O   1 
ATOM   1607 O  O   B GLY A 1 206 ? -16.838 -46.072 20.899  0.60 17.39 ? 428  GLY A O   1 
ATOM   1608 N  N   . LEU A 1 207 ? -14.944 -46.252 22.103  1.00 16.82 ? 429  LEU A N   1 
ATOM   1609 C  CA  . LEU A 1 207 ? -14.144 -46.445 20.899  1.00 16.82 ? 429  LEU A CA  1 
ATOM   1610 C  C   . LEU A 1 207 ? -14.490 -47.772 20.241  1.00 17.23 ? 429  LEU A C   1 
ATOM   1611 O  O   . LEU A 1 207 ? -14.641 -48.798 20.909  1.00 16.80 ? 429  LEU A O   1 
ATOM   1612 C  CB  . LEU A 1 207 ? -12.646 -46.417 21.224  1.00 18.02 ? 429  LEU A CB  1 
ATOM   1613 C  CG  . LEU A 1 207 ? -11.996 -45.094 21.646  1.00 22.68 ? 429  LEU A CG  1 
ATOM   1614 C  CD1 . LEU A 1 207 ? -10.543 -45.333 22.042  1.00 25.59 ? 429  LEU A CD1 1 
ATOM   1615 C  CD2 . LEU A 1 207 ? -12.072 -44.056 20.545  1.00 20.38 ? 429  LEU A CD2 1 
ATOM   1616 N  N   . ALA A 1 208 ? -14.620 -47.752 18.920  1.00 15.98 ? 430  ALA A N   1 
ATOM   1617 C  CA  . ALA A 1 208 ? -14.655 -49.005 18.189  1.00 14.32 ? 430  ALA A CA  1 
ATOM   1618 C  C   . ALA A 1 208 ? -13.322 -49.720 18.381  1.00 14.28 ? 430  ALA A C   1 
ATOM   1619 O  O   . ALA A 1 208 ? -12.262 -49.079 18.342  1.00 16.27 ? 430  ALA A O   1 
ATOM   1620 C  CB  . ALA A 1 208 ? -14.897 -48.763 16.694  1.00 14.01 ? 430  ALA A CB  1 
ATOM   1621 N  N   . PRO A 1 209 ? -13.329 -51.031 18.569  1.00 16.18 ? 431  PRO A N   1 
ATOM   1622 C  CA  . PRO A 1 209 ? -12.093 -51.744 18.893  1.00 20.17 ? 431  PRO A CA  1 
ATOM   1623 C  C   . PRO A 1 209 ? -11.199 -51.905 17.671  1.00 19.62 ? 431  PRO A C   1 
ATOM   1624 O  O   . PRO A 1 209 ? -11.616 -51.731 16.525  1.00 17.55 ? 431  PRO A O   1 
ATOM   1625 C  CB  . PRO A 1 209 ? -12.602 -53.103 19.370  1.00 22.92 ? 431  PRO A CB  1 
ATOM   1626 C  CG  . PRO A 1 209 ? -13.825 -53.313 18.521  1.00 24.49 ? 431  PRO A CG  1 
ATOM   1627 C  CD  . PRO A 1 209 ? -14.471 -51.951 18.432  1.00 23.13 ? 431  PRO A CD  1 
ATOM   1628 N  N   . ALA A 1 210 ? -9.953  -52.281 17.942  1.00 16.11 ? 432  ALA A N   1 
ATOM   1629 C  CA  . ALA A 1 210 ? -9.027  -52.576 16.862  1.00 15.58 ? 432  ALA A CA  1 
ATOM   1630 C  C   . ALA A 1 210 ? -9.589  -53.679 15.978  1.00 14.66 ? 432  ALA A C   1 
ATOM   1631 O  O   . ALA A 1 210 ? -10.128 -54.676 16.468  1.00 16.39 ? 432  ALA A O   1 
ATOM   1632 C  CB  . ALA A 1 210 ? -7.668  -53.002 17.419  1.00 20.45 ? 432  ALA A CB  1 
ATOM   1633 N  N   . ALA A 1 211 ? -9.476  -53.481 14.669  1.00 14.31 ? 433  ALA A N   1 
ATOM   1634 C  CA  . ALA A 1 211 ? -9.756  -54.522 13.690  1.00 13.69 ? 433  ALA A CA  1 
ATOM   1635 C  C   . ALA A 1 211 ? -8.442  -55.210 13.357  1.00 16.11 ? 433  ALA A C   1 
ATOM   1636 O  O   . ALA A 1 211 ? -7.481  -54.544 12.965  1.00 14.86 ? 433  ALA A O   1 
ATOM   1637 C  CB  . ALA A 1 211 ? -10.382 -53.924 12.430  1.00 13.43 ? 433  ALA A CB  1 
ATOM   1638 N  N   . ALA A 1 212 ? -8.392  -56.536 13.523  1.00 15.60 ? 434  ALA A N   1 
ATOM   1639 C  CA  . ALA A 1 212 ? -7.125  -57.220 13.324  1.00 22.86 ? 434  ALA A CA  1 
ATOM   1640 C  C   . ALA A 1 212 ? -7.383  -58.610 12.774  1.00 19.16 ? 434  ALA A C   1 
ATOM   1641 O  O   . ALA A 1 212 ? -8.342  -59.263 13.208  1.00 18.76 ? 434  ALA A O   1 
ATOM   1642 C  CB  . ALA A 1 212 ? -6.342  -57.325 14.637  1.00 33.63 ? 434  ALA A CB  1 
ATOM   1643 N  N   . PRO A 1 213 ? -6.564  -59.094 11.846  1.00 16.24 ? 435  PRO A N   1 
ATOM   1644 C  CA  . PRO A 1 213 ? -6.694  -60.493 11.430  1.00 14.27 ? 435  PRO A CA  1 
ATOM   1645 C  C   . PRO A 1 213 ? -6.359  -61.387 12.607  1.00 14.37 ? 435  PRO A C   1 
ATOM   1646 O  O   . PRO A 1 213 ? -5.641  -60.984 13.527  1.00 16.84 ? 435  PRO A O   1 
ATOM   1647 C  CB  . PRO A 1 213 ? -5.657  -60.641 10.305  1.00 19.27 ? 435  PRO A CB  1 
ATOM   1648 C  CG  . PRO A 1 213 ? -5.320  -59.226 9.899   1.00 21.81 ? 435  PRO A CG  1 
ATOM   1649 C  CD  . PRO A 1 213 ? -5.472  -58.405 11.138  1.00 21.05 ? 435  PRO A CD  1 
ATOM   1650 N  N   . ASP A 1 214 ? -6.902  -62.604 12.590  1.00 14.62 ? 436  ASP A N   1 
ATOM   1651 C  CA  . ASP A 1 214 ? -6.520  -63.582 13.604  1.00 14.45 ? 436  ASP A CA  1 
ATOM   1652 C  C   . ASP A 1 214 ? -5.877  -64.815 12.987  1.00 18.91 ? 436  ASP A C   1 
ATOM   1653 O  O   . ASP A 1 214 ? -5.624  -65.794 13.692  1.00 19.35 ? 436  ASP A O   1 
ATOM   1654 C  CB  . ASP A 1 214 ? -7.713  -63.959 14.499  1.00 18.40 ? 436  ASP A CB  1 
ATOM   1655 C  CG  . ASP A 1 214 ? -8.886  -64.561 13.744  1.00 22.74 ? 436  ASP A CG  1 
ATOM   1656 O  OD1 . ASP A 1 214 ? -8.763  -64.901 12.548  1.00 19.79 ? 436  ASP A OD1 1 
ATOM   1657 O  OD2 . ASP A 1 214 ? -9.959  -64.689 14.383  1.00 21.87 ? 436  ASP A OD2 1 
ATOM   1658 N  N   . PHE A 1 215 ? -5.590  -64.773 11.689  1.00 13.96 ? 437  PHE A N   1 
ATOM   1659 C  CA  . PHE A 1 215 ? -4.913  -65.828 10.968  1.00 16.36 ? 437  PHE A CA  1 
ATOM   1660 C  C   . PHE A 1 215 ? -3.547  -65.312 10.581  1.00 26.67 ? 437  PHE A C   1 
ATOM   1661 O  O   . PHE A 1 215 ? -3.471  -64.297 9.868   1.00 19.07 ? 437  PHE A O   1 
ATOM   1662 C  CB  . PHE A 1 215 ? -5.687  -66.191 9.704   1.00 20.85 ? 437  PHE A CB  1 
ATOM   1663 C  CG  . PHE A 1 215 ? -6.279  -67.552 9.704   1.00 19.59 ? 437  PHE A CG  1 
ATOM   1664 C  CD1 . PHE A 1 215 ? -7.183  -67.926 10.675  1.00 19.69 ? 437  PHE A CD1 1 
ATOM   1665 C  CD2 . PHE A 1 215 ? -5.996  -68.435 8.665   1.00 22.22 ? 437  PHE A CD2 1 
ATOM   1666 C  CE1 . PHE A 1 215 ? -7.762  -69.173 10.641  1.00 19.22 ? 437  PHE A CE1 1 
ATOM   1667 C  CE2 . PHE A 1 215 ? -6.569  -69.688 8.629   1.00 21.14 ? 437  PHE A CE2 1 
ATOM   1668 C  CZ  . PHE A 1 215 ? -7.457  -70.053 9.615   1.00 18.74 ? 437  PHE A CZ  1 
ATOM   1669 N  N   . PRO A 1 216 ? -2.456  -65.947 10.992  1.00 18.23 ? 438  PRO A N   1 
ATOM   1670 C  CA  . PRO A 1 216 ? -1.174  -65.613 10.378  1.00 19.74 ? 438  PRO A CA  1 
ATOM   1671 C  C   . PRO A 1 216 ? -1.273  -65.865 8.876   1.00 20.73 ? 438  PRO A C   1 
ATOM   1672 O  O   . PRO A 1 216 ? -1.906  -66.823 8.422   1.00 28.60 ? 438  PRO A O   1 
ATOM   1673 C  CB  . PRO A 1 216 ? -0.186  -66.563 11.068  1.00 28.69 ? 438  PRO A CB  1 
ATOM   1674 C  CG  . PRO A 1 216 ? -0.865  -66.947 12.363  1.00 20.09 ? 438  PRO A CG  1 
ATOM   1675 C  CD  . PRO A 1 216 ? -2.328  -67.020 11.995  1.00 17.29 ? 438  PRO A CD  1 
ATOM   1676 N  N   . GLY A 1 217 ? -0.686  -64.975 8.103   1.00 27.24 ? 439  GLY A N   1 
ATOM   1677 C  CA  . GLY A 1 217 ? -0.818  -65.082 6.673   1.00 20.36 ? 439  GLY A CA  1 
ATOM   1678 C  C   . GLY A 1 217 ? -1.973  -64.300 6.097   1.00 23.48 ? 439  GLY A C   1 
ATOM   1679 O  O   . GLY A 1 217 ? -2.024  -64.123 4.876   1.00 16.46 ? 439  GLY A O   1 
ATOM   1680 N  N   . GLU A 1 218 ? -2.896  -63.824 6.931   1.00 16.16 ? 440  GLU A N   1 
ATOM   1681 C  CA  . GLU A 1 218 ? -3.950  -62.923 6.483   1.00 15.43 ? 440  GLU A CA  1 
ATOM   1682 C  C   . GLU A 1 218 ? -3.622  -61.489 6.875   1.00 15.13 ? 440  GLU A C   1 
ATOM   1683 O  O   . GLU A 1 218 ? -2.970  -61.232 7.887   1.00 16.80 ? 440  GLU A O   1 
ATOM   1684 C  CB  . GLU A 1 218 ? -5.315  -63.311 7.065   1.00 15.13 ? 440  GLU A CB  1 
ATOM   1685 C  CG  . GLU A 1 218 ? -5.930  -64.546 6.425   1.00 14.96 ? 440  GLU A CG  1 
ATOM   1686 C  CD  . GLU A 1 218 ? -7.300  -64.880 7.000   1.00 17.62 ? 440  GLU A CD  1 
ATOM   1687 O  OE1 . GLU A 1 218 ? -7.929  -63.984 7.610   1.00 19.00 ? 440  GLU A OE1 1 
ATOM   1688 O  OE2 . GLU A 1 218 ? -7.741  -66.039 6.845   1.00 16.97 ? 440  GLU A OE2 1 
ATOM   1689 N  N   A MET A 1 219 ? -4.075  -60.547 6.058   0.46 12.44 ? 441  MET A N   1 
ATOM   1690 N  N   B MET A 1 219 ? -4.089  -60.555 6.047   0.54 12.41 ? 441  MET A N   1 
ATOM   1691 C  CA  A MET A 1 219 ? -3.924  -59.145 6.392   0.46 13.95 ? 441  MET A CA  1 
ATOM   1692 C  CA  B MET A 1 219 ? -3.893  -59.132 6.255   0.54 14.16 ? 441  MET A CA  1 
ATOM   1693 C  C   A MET A 1 219 ? -5.183  -58.410 5.974   0.46 14.62 ? 441  MET A C   1 
ATOM   1694 C  C   B MET A 1 219 ? -5.209  -58.423 5.985   0.54 14.61 ? 441  MET A C   1 
ATOM   1695 O  O   A MET A 1 219 ? -5.984  -58.906 5.177   0.46 13.91 ? 441  MET A O   1 
ATOM   1696 O  O   B MET A 1 219 ? -6.083  -58.952 5.293   0.54 13.90 ? 441  MET A O   1 
ATOM   1697 C  CB  A MET A 1 219 ? -2.686  -58.519 5.729   0.46 20.19 ? 441  MET A CB  1 
ATOM   1698 C  CB  B MET A 1 219 ? -2.794  -58.569 5.334   0.54 16.08 ? 441  MET A CB  1 
ATOM   1699 C  CG  A MET A 1 219 ? -1.377  -58.824 6.454   0.46 17.32 ? 441  MET A CG  1 
ATOM   1700 C  CG  B MET A 1 219 ? -1.392  -59.021 5.714   0.54 21.18 ? 441  MET A CG  1 
ATOM   1701 S  SD  A MET A 1 219 ? 0.033   -58.019 5.667   0.46 17.10 ? 441  MET A SD  1 
ATOM   1702 S  SD  B MET A 1 219 ? -0.108  -58.179 4.773   0.54 28.17 ? 441  MET A SD  1 
ATOM   1703 C  CE  A MET A 1 219 ? -0.195  -58.557 3.970   0.46 21.24 ? 441  MET A CE  1 
ATOM   1704 C  CE  B MET A 1 219 ? -0.119  -59.142 3.271   0.54 20.35 ? 441  MET A CE  1 
ATOM   1705 N  N   . ILE A 1 220 ? -5.342  -57.212 6.529   1.00 14.41 ? 442  ILE A N   1 
ATOM   1706 C  CA  . ILE A 1 220 ? -6.520  -56.400 6.256   1.00 10.19 ? 442  ILE A CA  1 
ATOM   1707 C  C   . ILE A 1 220 ? -6.514  -55.960 4.804   1.00 13.42 ? 442  ILE A C   1 
ATOM   1708 O  O   . ILE A 1 220 ? -5.493  -55.500 4.281   1.00 14.43 ? 442  ILE A O   1 
ATOM   1709 C  CB  . ILE A 1 220 ? -6.560  -55.170 7.173   1.00 13.07 ? 442  ILE A CB  1 
ATOM   1710 C  CG1 . ILE A 1 220 ? -6.728  -55.585 8.638   1.00 17.27 ? 442  ILE A CG1 1 
ATOM   1711 C  CG2 . ILE A 1 220 ? -7.670  -54.193 6.725   1.00 11.63 ? 442  ILE A CG2 1 
ATOM   1712 C  CD1 . ILE A 1 220 ? -6.646  -54.394 9.602   1.00 16.88 ? 442  ILE A CD1 1 
ATOM   1713 N  N   . LEU A 1 221 ? -7.664  -56.076 4.157   1.00 13.16 ? 443  LEU A N   1 
ATOM   1714 C  CA  . LEU A 1 221 ? -7.883  -55.471 2.853   1.00 12.60 ? 443  LEU A CA  1 
ATOM   1715 C  C   . LEU A 1 221 ? -8.486  -54.093 3.086   1.00 12.03 ? 443  LEU A C   1 
ATOM   1716 O  O   . LEU A 1 221 ? -9.631  -53.984 3.524   1.00 14.35 ? 443  LEU A O   1 
ATOM   1717 C  CB  . LEU A 1 221 ? -8.806  -56.353 2.015   1.00 11.71 ? 443  LEU A CB  1 
ATOM   1718 C  CG  . LEU A 1 221 ? -9.048  -55.863 0.586   1.00 15.05 ? 443  LEU A CG  1 
ATOM   1719 C  CD1 . LEU A 1 221 ? -7.744  -55.910 -0.199  1.00 15.72 ? 443  LEU A CD1 1 
ATOM   1720 C  CD2 . LEU A 1 221 ? -10.103 -56.726 -0.098  1.00 18.60 ? 443  LEU A CD2 1 
ATOM   1721 N  N   . TYR A 1 222 ? -7.726  -53.044 2.790   1.00 11.03 ? 444  TYR A N   1 
ATOM   1722 C  CA  . TYR A 1 222 ? -8.203  -51.683 2.984   1.00 10.47 ? 444  TYR A CA  1 
ATOM   1723 C  C   . TYR A 1 222 ? -8.824  -51.137 1.709   1.00 11.88 ? 444  TYR A C   1 
ATOM   1724 O  O   . TYR A 1 222 ? -8.399  -51.476 0.607   1.00 12.39 ? 444  TYR A O   1 
ATOM   1725 C  CB  . TYR A 1 222 ? -7.054  -50.756 3.367   1.00 11.20 ? 444  TYR A CB  1 
ATOM   1726 C  CG  . TYR A 1 222 ? -6.471  -50.926 4.754   1.00 10.72 ? 444  TYR A CG  1 
ATOM   1727 C  CD1 . TYR A 1 222 ? -7.087  -50.339 5.860   1.00 12.46 ? 444  TYR A CD1 1 
ATOM   1728 C  CD2 . TYR A 1 222 ? -5.274  -51.603 4.946   1.00 10.26 ? 444  TYR A CD2 1 
ATOM   1729 C  CE1 . TYR A 1 222 ? -6.527  -50.438 7.123   1.00 11.66 ? 444  TYR A CE1 1 
ATOM   1730 C  CE2 . TYR A 1 222 ? -4.710  -51.717 6.226   1.00 11.06 ? 444  TYR A CE2 1 
ATOM   1731 C  CZ  . TYR A 1 222 ? -5.343  -51.124 7.300   1.00 17.28 ? 444  TYR A CZ  1 
ATOM   1732 O  OH  . TYR A 1 222 ? -4.785  -51.208 8.565   1.00 14.53 ? 444  TYR A OH  1 
ATOM   1733 N  N   . PHE A 1 223 ? -9.804  -50.249 1.868   1.00 11.90 ? 445  PHE A N   1 
ATOM   1734 C  CA  . PHE A 1 223 ? -10.349 -49.485 0.750   1.00 11.70 ? 445  PHE A CA  1 
ATOM   1735 C  C   . PHE A 1 223 ? -9.666  -48.126 0.733   1.00 11.93 ? 445  PHE A C   1 
ATOM   1736 O  O   . PHE A 1 223 ? -9.447  -47.532 1.791   1.00 14.72 ? 445  PHE A O   1 
ATOM   1737 C  CB  . PHE A 1 223 ? -11.868 -49.357 0.888   1.00 10.30 ? 445  PHE A CB  1 
ATOM   1738 C  CG  . PHE A 1 223 ? -12.571 -50.685 0.842   1.00 12.72 ? 445  PHE A CG  1 
ATOM   1739 C  CD1 . PHE A 1 223 ? -12.640 -51.488 1.975   1.00 11.39 ? 445  PHE A CD1 1 
ATOM   1740 C  CD2 . PHE A 1 223 ? -13.113 -51.152 -0.346  1.00 13.16 ? 445  PHE A CD2 1 
ATOM   1741 C  CE1 . PHE A 1 223 ? -13.252 -52.724 1.933   1.00 10.69 ? 445  PHE A CE1 1 
ATOM   1742 C  CE2 . PHE A 1 223 ? -13.733 -52.383 -0.400  1.00 13.04 ? 445  PHE A CE2 1 
ATOM   1743 C  CZ  . PHE A 1 223 ? -13.804 -53.173 0.756   1.00 11.71 ? 445  PHE A CZ  1 
ATOM   1744 N  N   . VAL A 1 224 ? -9.323  -47.629 -0.464  1.00 11.11 ? 446  VAL A N   1 
ATOM   1745 C  CA  A VAL A 1 224 ? -8.410  -46.499 -0.675  0.73 12.07 ? 446  VAL A CA  1 
ATOM   1746 C  CA  B VAL A 1 224 ? -8.471  -46.455 -0.545  0.27 11.78 ? 446  VAL A CA  1 
ATOM   1747 C  C   . VAL A 1 224 ? -9.136  -45.350 -1.359  1.00 12.79 ? 446  VAL A C   1 
ATOM   1748 O  O   . VAL A 1 224 ? -9.853  -45.588 -2.338  1.00 12.73 ? 446  VAL A O   1 
ATOM   1749 C  CB  A VAL A 1 224 ? -7.226  -46.904 -1.587  0.73 11.83 ? 446  VAL A CB  1 
ATOM   1750 C  CB  B VAL A 1 224 ? -7.078  -46.811 -1.108  0.27 15.14 ? 446  VAL A CB  1 
ATOM   1751 C  CG1 A VAL A 1 224 ? -6.303  -45.709 -1.834  0.73 15.12 ? 446  VAL A CG1 1 
ATOM   1752 C  CG1 B VAL A 1 224 ? -7.142  -47.065 -2.594  0.27 16.24 ? 446  VAL A CG1 1 
ATOM   1753 C  CG2 A VAL A 1 224 ? -6.484  -48.064 -1.047  0.73 11.99 ? 446  VAL A CG2 1 
ATOM   1754 C  CG2 B VAL A 1 224 ? -6.074  -45.720 -0.759  0.27 9.27  ? 446  VAL A CG2 1 
ATOM   1755 N  N   . SER A 1 225 ? -8.887  -44.115 -0.917  1.00 11.91 ? 447  SER A N   1 
ATOM   1756 C  CA  . SER A 1 225 ? -9.235  -42.905 -1.659  1.00 13.19 ? 447  SER A CA  1 
ATOM   1757 C  C   . SER A 1 225 ? -8.034  -41.964 -1.666  1.00 12.68 ? 447  SER A C   1 
ATOM   1758 O  O   . SER A 1 225 ? -7.171  -42.019 -0.784  1.00 14.22 ? 447  SER A O   1 
ATOM   1759 C  CB  . SER A 1 225 ? -10.438 -42.166 -1.046  1.00 14.40 ? 447  SER A CB  1 
ATOM   1760 O  OG  . SER A 1 225 ? -11.572 -43.002 -0.957  1.00 12.76 ? 447  SER A OG  1 
ATOM   1761 N  N   . ASP A 1 226 ? -8.002  -41.057 -2.643  1.00 12.91 ? 448  ASP A N   1 
ATOM   1762 C  CA  . ASP A 1 226 ? -7.013  -39.978 -2.638  1.00 12.44 ? 448  ASP A CA  1 
ATOM   1763 C  C   . ASP A 1 226 ? -7.577  -38.787 -1.868  1.00 14.95 ? 448  ASP A C   1 
ATOM   1764 O  O   . ASP A 1 226 ? -8.660  -38.288 -2.198  1.00 14.41 ? 448  ASP A O   1 
ATOM   1765 C  CB  . ASP A 1 226 ? -6.653  -39.560 -4.063  1.00 12.89 ? 448  ASP A CB  1 
ATOM   1766 C  CG  . ASP A 1 226 ? -5.799  -40.585 -4.780  1.00 15.23 ? 448  ASP A CG  1 
ATOM   1767 O  OD1 . ASP A 1 226 ? -4.885  -41.172 -4.157  1.00 17.30 ? 448  ASP A OD1 1 
ATOM   1768 O  OD2 . ASP A 1 226 ? -6.046  -40.798 -5.980  1.00 18.35 ? 448  ASP A OD2 1 
ATOM   1769 N  N   . MET A 1 227 ? -6.840  -38.343 -0.835  1.00 12.27 ? 449  MET A N   1 
ATOM   1770 C  CA  A MET A 1 227 ? -7.240  -37.184 -0.051  0.67 14.53 ? 449  MET A CA  1 
ATOM   1771 C  CA  B MET A 1 227 ? -7.211  -37.171 -0.034  0.33 14.58 ? 449  MET A CA  1 
ATOM   1772 C  C   . MET A 1 227 ? -6.874  -35.896 -0.792  1.00 16.58 ? 449  MET A C   1 
ATOM   1773 O  O   . MET A 1 227 ? -5.734  -35.744 -1.245  1.00 16.39 ? 449  MET A O   1 
ATOM   1774 C  CB  A MET A 1 227 ? -6.563  -37.238 1.326   0.67 14.87 ? 449  MET A CB  1 
ATOM   1775 C  CB  B MET A 1 227 ? -6.442  -37.149 1.287   0.33 14.95 ? 449  MET A CB  1 
ATOM   1776 C  CG  A MET A 1 227 ? -6.731  -35.997 2.180   0.67 15.08 ? 449  MET A CG  1 
ATOM   1777 C  CG  B MET A 1 227 ? -6.990  -37.999 2.385   0.33 16.85 ? 449  MET A CG  1 
ATOM   1778 S  SD  A MET A 1 227 ? -8.441  -35.653 2.629   0.67 15.53 ? 449  MET A SD  1 
ATOM   1779 S  SD  B MET A 1 227 ? -8.601  -37.462 2.960   0.33 15.05 ? 449  MET A SD  1 
ATOM   1780 C  CE  A MET A 1 227 ? -8.613  -36.615 4.133   0.67 11.13 ? 449  MET A CE  1 
ATOM   1781 C  CE  B MET A 1 227 ? -8.275  -35.764 3.418   0.33 13.26 ? 449  MET A CE  1 
ATOM   1782 N  N   . PRO A 1 228 ? -7.810  -34.955 -0.946  1.00 15.18 ? 450  PRO A N   1 
ATOM   1783 C  CA  A PRO A 1 228 ? -7.434  -33.656 -1.520  0.60 14.68 ? 450  PRO A CA  1 
ATOM   1784 C  CA  B PRO A 1 228 ? -7.444  -33.650 -1.515  0.40 14.72 ? 450  PRO A CA  1 
ATOM   1785 C  C   . PRO A 1 228 ? -6.513  -32.906 -0.566  1.00 15.55 ? 450  PRO A C   1 
ATOM   1786 O  O   . PRO A 1 228 ? -6.757  -32.845 0.641   1.00 15.01 ? 450  PRO A O   1 
ATOM   1787 C  CB  A PRO A 1 228 ? -8.777  -32.936 -1.711  0.60 16.37 ? 450  PRO A CB  1 
ATOM   1788 C  CB  B PRO A 1 228 ? -8.791  -32.928 -1.670  0.40 16.36 ? 450  PRO A CB  1 
ATOM   1789 C  CG  A PRO A 1 228 ? -9.727  -33.642 -0.802  0.60 16.54 ? 450  PRO A CG  1 
ATOM   1790 C  CG  B PRO A 1 228 ? -9.837  -34.002 -1.563  0.40 15.39 ? 450  PRO A CG  1 
ATOM   1791 C  CD  A PRO A 1 228 ? -9.262  -35.067 -0.728  0.60 15.62 ? 450  PRO A CD  1 
ATOM   1792 C  CD  B PRO A 1 228 ? -9.249  -35.044 -0.654  0.40 15.62 ? 450  PRO A CD  1 
ATOM   1793 N  N   . VAL A 1 229 ? -5.446  -32.340 -1.125  1.00 15.81 ? 451  VAL A N   1 
ATOM   1794 C  CA  . VAL A 1 229 ? -4.403  -31.672 -0.358  1.00 15.61 ? 451  VAL A CA  1 
ATOM   1795 C  C   . VAL A 1 229 ? -4.241  -30.260 -0.899  1.00 14.85 ? 451  VAL A C   1 
ATOM   1796 O  O   . VAL A 1 229 ? -4.248  -30.053 -2.116  1.00 14.82 ? 451  VAL A O   1 
ATOM   1797 C  CB  . VAL A 1 229 ? -3.070  -32.448 -0.445  1.00 19.33 ? 451  VAL A CB  1 
ATOM   1798 C  CG1 . VAL A 1 229 ? -1.927  -31.660 0.217   1.00 18.19 ? 451  VAL A CG1 1 
ATOM   1799 C  CG2 . VAL A 1 229 ? -3.222  -33.852 0.165   1.00 14.98 ? 451  VAL A CG2 1 
ATOM   1800 N  N   . ARG A 1 230 ? -4.101  -29.290 0.002   1.00 14.88 ? 452  ARG A N   1 
ATOM   1801 C  CA  . ARG A 1 230 ? -3.821  -27.901 -0.384  1.00 15.46 ? 452  ARG A CA  1 
ATOM   1802 C  C   . ARG A 1 230 ? -2.737  -27.402 0.567   1.00 16.33 ? 452  ARG A C   1 
ATOM   1803 O  O   . ARG A 1 230 ? -3.027  -26.928 1.668   1.00 17.47 ? 452  ARG A O   1 
ATOM   1804 C  CB  . ARG A 1 230 ? -5.064  -27.018 -0.336  1.00 15.76 ? 452  ARG A CB  1 
ATOM   1805 C  CG  . ARG A 1 230 ? -4.776  -25.534 -0.626  1.00 17.38 ? 452  ARG A CG  1 
ATOM   1806 C  CD  . ARG A 1 230 ? -6.034  -24.673 -0.542  1.00 20.78 ? 452  ARG A CD  1 
ATOM   1807 N  NE  . ARG A 1 230 ? -5.692  -23.264 -0.385  1.00 23.47 ? 452  ARG A NE  1 
ATOM   1808 C  CZ  . ARG A 1 230 ? -5.328  -22.463 -1.378  1.00 28.07 ? 452  ARG A CZ  1 
ATOM   1809 N  NH1 . ARG A 1 230 ? -5.269  -22.890 -2.624  1.00 26.03 ? 452  ARG A NH1 1 
ATOM   1810 N  NH2 . ARG A 1 230 ? -4.998  -21.203 -1.109  1.00 27.88 ? 452  ARG A NH2 1 
ATOM   1811 N  N   . ASN A 1 231 ? -1.507  -27.530 0.150   1.00 18.11 ? 453  ASN A N   1 
ATOM   1812 C  CA  . ASN A 1 231 ? -0.401  -26.999 0.932   1.00 15.75 ? 453  ASN A CA  1 
ATOM   1813 C  C   . ASN A 1 231 ? -0.008  -25.625 0.411   1.00 25.02 ? 453  ASN A C   1 
ATOM   1814 O  O   . ASN A 1 231 ? -0.229  -25.320 -0.763  1.00 24.04 ? 453  ASN A O   1 
ATOM   1815 C  CB  . ASN A 1 231 ? 0.816   -27.929 0.849   1.00 20.53 ? 453  ASN A CB  1 
ATOM   1816 C  CG  . ASN A 1 231 ? 0.586   -29.241 1.551   1.00 22.87 ? 453  ASN A CG  1 
ATOM   1817 O  OD1 . ASN A 1 231 ? -0.101  -29.287 2.564   1.00 21.96 ? 453  ASN A OD1 1 
ATOM   1818 N  ND2 . ASN A 1 231 ? 1.167   -30.324 1.018   1.00 19.00 ? 453  ASN A ND2 1 
ATOM   1819 N  N   . PRO A 1 232 ? 0.573   -24.781 1.261   1.00 27.77 ? 454  PRO A N   1 
ATOM   1820 C  CA  . PRO A 1 232 ? 1.054   -23.477 0.790   1.00 33.82 ? 454  PRO A CA  1 
ATOM   1821 C  C   . PRO A 1 232 ? 1.936   -23.621 -0.445  1.00 32.89 ? 454  PRO A C   1 
ATOM   1822 O  O   . PRO A 1 232 ? 2.779   -24.516 -0.531  1.00 35.36 ? 454  PRO A O   1 
ATOM   1823 C  CB  . PRO A 1 232 ? 1.841   -22.944 1.989   1.00 37.43 ? 454  PRO A CB  1 
ATOM   1824 C  CG  . PRO A 1 232 ? 1.174   -23.572 3.165   1.00 33.22 ? 454  PRO A CG  1 
ATOM   1825 C  CD  . PRO A 1 232 ? 0.781   -24.957 2.709   1.00 25.99 ? 454  PRO A CD  1 
ATOM   1826 N  N   . ASN A 1 233 ? 1.698   -22.749 -1.422  1.00 34.14 ? 455  ASN A N   1 
ATOM   1827 C  CA  . ASN A 1 233 ? 2.439   -22.703 -2.682  1.00 47.94 ? 455  ASN A CA  1 
ATOM   1828 C  C   . ASN A 1 233 ? 2.299   -23.987 -3.497  1.00 42.03 ? 455  ASN A C   1 
ATOM   1829 O  O   . ASN A 1 233 ? 3.092   -24.232 -4.410  1.00 35.20 ? 455  ASN A O   1 
ATOM   1830 C  CB  . ASN A 1 233 ? 3.923   -22.391 -2.447  1.00 38.77 ? 455  ASN A CB  1 
ATOM   1831 C  CG  . ASN A 1 233 ? 4.134   -21.261 -1.456  1.00 53.12 ? 455  ASN A CG  1 
ATOM   1832 O  OD1 . ASN A 1 233 ? 3.877   -20.096 -1.762  1.00 60.02 ? 455  ASN A OD1 1 
ATOM   1833 N  ND2 . ASN A 1 233 ? 4.608   -21.601 -0.261  1.00 52.98 ? 455  ASN A ND2 1 
ATOM   1834 N  N   . GLY A 1 234 ? 1.300   -24.818 -3.199  1.00 32.98 ? 456  GLY A N   1 
ATOM   1835 C  CA  . GLY A 1 234 ? 1.136   -26.043 -3.956  1.00 25.71 ? 456  GLY A CA  1 
ATOM   1836 C  C   . GLY A 1 234 ? 2.164   -27.113 -3.668  1.00 22.41 ? 456  GLY A C   1 
ATOM   1837 O  O   . GLY A 1 234 ? 2.303   -28.052 -4.462  1.00 22.81 ? 456  GLY A O   1 
ATOM   1838 N  N   . GLU A 1 235 ? 2.889   -27.001 -2.555  1.00 22.34 ? 457  GLU A N   1 
ATOM   1839 C  CA  A GLU A 1 235 ? 3.878   -28.009 -2.195  0.43 25.52 ? 457  GLU A CA  1 
ATOM   1840 C  CA  B GLU A 1 235 ? 3.879   -28.009 -2.200  0.57 25.48 ? 457  GLU A CA  1 
ATOM   1841 C  C   . GLU A 1 235 ? 3.255   -29.398 -2.234  1.00 28.90 ? 457  GLU A C   1 
ATOM   1842 O  O   . GLU A 1 235 ? 2.150   -29.613 -1.731  1.00 22.17 ? 457  GLU A O   1 
ATOM   1843 C  CB  A GLU A 1 235 ? 4.448   -27.708 -0.807  0.43 25.97 ? 457  GLU A CB  1 
ATOM   1844 C  CB  B GLU A 1 235 ? 4.461   -27.723 -0.816  0.57 25.90 ? 457  GLU A CB  1 
ATOM   1845 C  CG  A GLU A 1 235 ? 5.387   -26.513 -0.795  0.43 39.00 ? 457  GLU A CG  1 
ATOM   1846 C  CG  B GLU A 1 235 ? 5.499   -28.738 -0.390  0.57 26.69 ? 457  GLU A CG  1 
ATOM   1847 C  CD  A GLU A 1 235 ? 5.284   -25.680 0.469   0.43 43.02 ? 457  GLU A CD  1 
ATOM   1848 C  CD  B GLU A 1 235 ? 6.248   -28.324 0.855   0.57 42.78 ? 457  GLU A CD  1 
ATOM   1849 O  OE1 A GLU A 1 235 ? 4.377   -25.940 1.290   0.43 37.55 ? 457  GLU A OE1 1 
ATOM   1850 O  OE1 B GLU A 1 235 ? 5.799   -27.379 1.537   0.57 44.05 ? 457  GLU A OE1 1 
ATOM   1851 O  OE2 A GLU A 1 235 ? 6.105   -24.753 0.631   0.43 44.30 ? 457  GLU A OE2 1 
ATOM   1852 O  OE2 B GLU A 1 235 ? 7.293   -28.942 1.147   0.57 41.02 ? 457  GLU A OE2 1 
ATOM   1853 N  N   . ARG A 1 236 ? 3.965   -30.335 -2.844  1.00 23.44 ? 458  ARG A N   1 
ATOM   1854 C  CA  . ARG A 1 236 ? 3.404   -31.644 -3.142  1.00 19.90 ? 458  ARG A CA  1 
ATOM   1855 C  C   . ARG A 1 236 ? 3.699   -32.637 -2.027  1.00 24.03 ? 458  ARG A C   1 
ATOM   1856 O  O   . ARG A 1 236 ? 4.862   -32.895 -1.706  1.00 21.40 ? 458  ARG A O   1 
ATOM   1857 C  CB  . ARG A 1 236 ? 3.951   -32.160 -4.468  1.00 22.75 ? 458  ARG A CB  1 
ATOM   1858 C  CG  . ARG A 1 236 ? 3.382   -33.499 -4.849  1.00 25.95 ? 458  ARG A CG  1 
ATOM   1859 C  CD  . ARG A 1 236 ? 3.920   -33.959 -6.182  1.00 24.22 ? 458  ARG A CD  1 
ATOM   1860 N  NE  . ARG A 1 236 ? 3.156   -35.094 -6.680  1.00 20.44 ? 458  ARG A NE  1 
ATOM   1861 C  CZ  . ARG A 1 236 ? 3.315   -35.627 -7.881  1.00 30.54 ? 458  ARG A CZ  1 
ATOM   1862 N  NH1 . ARG A 1 236 ? 4.240   -35.180 -8.719  1.00 31.95 ? 458  ARG A NH1 1 
ATOM   1863 N  NH2 . ARG A 1 236 ? 2.523   -36.628 -8.254  1.00 27.37 ? 458  ARG A NH2 1 
ATOM   1864 N  N   . ARG A 1 237 ? 2.642   -33.210 -1.457  0.93 18.69 ? 459  ARG A N   1 
ATOM   1865 C  CA  . ARG A 1 237 ? 2.775   -34.394 -0.611  0.93 17.86 ? 459  ARG A CA  1 
ATOM   1866 C  C   . ARG A 1 237 ? 1.448   -35.147 -0.731  0.93 21.02 ? 459  ARG A C   1 
ATOM   1867 O  O   . ARG A 1 237 ? 0.543   -34.971 0.090   0.93 17.68 ? 459  ARG A O   1 
ATOM   1868 C  CB  . ARG A 1 237 ? 3.096   -34.050 0.832   0.93 18.29 ? 459  ARG A CB  1 
ATOM   1869 C  CG  . ARG A 1 237 ? 3.324   -35.295 1.656   0.93 28.62 ? 459  ARG A CG  1 
ATOM   1870 C  CD  . ARG A 1 237 ? 3.701   -34.949 3.048   0.93 43.37 ? 459  ARG A CD  1 
ATOM   1871 N  NE  . ARG A 1 237 ? 4.992   -34.273 3.129   0.93 49.89 ? 459  ARG A NE  1 
ATOM   1872 C  CZ  . ARG A 1 237 ? 6.152   -34.892 3.313   0.93 50.63 ? 459  ARG A CZ  1 
ATOM   1873 N  NH1 . ARG A 1 237 ? 6.221   -36.209 3.435   0.93 47.02 ? 459  ARG A NH1 1 
ATOM   1874 N  NH2 . ARG A 1 237 ? 7.267   -34.171 3.391   0.93 46.41 ? 459  ARG A NH2 1 
ATOM   1875 N  N   . ASP A 1 238 ? 1.349   -35.969 -1.769  1.00 17.09 ? 460  ASP A N   1 
ATOM   1876 C  CA  . ASP A 1 238 ? 0.104   -36.667 -2.056  1.00 19.71 ? 460  ASP A CA  1 
ATOM   1877 C  C   . ASP A 1 238 ? -0.183  -37.675 -0.950  1.00 21.11 ? 460  ASP A C   1 
ATOM   1878 O  O   . ASP A 1 238 ? 0.733   -38.289 -0.396  1.00 18.19 ? 460  ASP A O   1 
ATOM   1879 C  CB  . ASP A 1 238 ? 0.191   -37.351 -3.421  1.00 18.11 ? 460  ASP A CB  1 
ATOM   1880 C  CG  . ASP A 1 238 ? 0.505   -36.372 -4.547  1.00 24.11 ? 460  ASP A CG  1 
ATOM   1881 O  OD1 . ASP A 1 238 ? 0.117   -35.190 -4.450  1.00 19.83 ? 460  ASP A OD1 1 
ATOM   1882 O  OD2 . ASP A 1 238 ? 1.158   -36.778 -5.536  1.00 24.09 ? 460  ASP A OD2 1 
ATOM   1883 N  N   . THR A 1 239 ? -1.465  -37.826 -0.613  1.00 15.80 ? 461  THR A N   1 
ATOM   1884 C  CA  . THR A 1 239 ? -1.869  -38.579 0.571   1.00 14.57 ? 461  THR A CA  1 
ATOM   1885 C  C   . THR A 1 239 ? -3.119  -39.392 0.269   1.00 14.94 ? 461  THR A C   1 
ATOM   1886 O  O   . THR A 1 239 ? -4.107  -38.848 -0.232  1.00 15.80 ? 461  THR A O   1 
ATOM   1887 C  CB  . THR A 1 239 ? -2.139  -37.624 1.745   1.00 18.05 ? 461  THR A CB  1 
ATOM   1888 O  OG1 . THR A 1 239 ? -0.986  -36.796 1.964   1.00 19.04 ? 461  THR A OG1 1 
ATOM   1889 C  CG2 . THR A 1 239 ? -2.449  -38.391 3.010   1.00 19.67 ? 461  THR A CG2 1 
ATOM   1890 N  N   . GLU A 1 240 ? -3.073  -40.685 0.572   1.00 13.99 ? 462  GLU A N   1 
ATOM   1891 C  CA  . GLU A 1 240 ? -4.245  -41.553 0.514   1.00 13.74 ? 462  GLU A CA  1 
ATOM   1892 C  C   . GLU A 1 240 ? -4.912  -41.600 1.883   1.00 11.57 ? 462  GLU A C   1 
ATOM   1893 O  O   . GLU A 1 240 ? -4.283  -41.330 2.903   1.00 14.68 ? 462  GLU A O   1 
ATOM   1894 C  CB  . GLU A 1 240 ? -3.850  -42.972 0.095   1.00 15.51 ? 462  GLU A CB  1 
ATOM   1895 C  CG  . GLU A 1 240 ? -3.378  -43.098 -1.369  1.00 16.41 ? 462  GLU A CG  1 
ATOM   1896 C  CD  . GLU A 1 240 ? -2.941  -44.516 -1.707  1.00 24.37 ? 462  GLU A CD  1 
ATOM   1897 O  OE1 . GLU A 1 240 ? -2.826  -45.338 -0.769  1.00 21.11 ? 462  GLU A OE1 1 
ATOM   1898 O  OE2 . GLU A 1 240 ? -2.718  -44.816 -2.903  1.00 18.44 ? 462  GLU A OE2 1 
ATOM   1899 N  N   . ILE A 1 241 ? -6.201  -41.941 1.904   1.00 14.43 ? 463  ILE A N   1 
ATOM   1900 C  CA  . ILE A 1 241 ? -6.881  -42.248 3.161   1.00 10.64 ? 463  ILE A CA  1 
ATOM   1901 C  C   . ILE A 1 241 ? -7.577  -43.591 3.007   1.00 12.46 ? 463  ILE A C   1 
ATOM   1902 O  O   . ILE A 1 241 ? -8.267  -43.832 2.007   1.00 13.60 ? 463  ILE A O   1 
ATOM   1903 C  CB  . ILE A 1 241 ? -7.874  -41.144 3.591   1.00 11.97 ? 463  ILE A CB  1 
ATOM   1904 C  CG1 . ILE A 1 241 ? -8.501  -41.493 4.945   1.00 12.19 ? 463  ILE A CG1 1 
ATOM   1905 C  CG2 . ILE A 1 241 ? -8.951  -40.875 2.520   1.00 12.55 ? 463  ILE A CG2 1 
ATOM   1906 C  CD1 . ILE A 1 241 ? -9.228  -40.317 5.579   1.00 14.34 ? 463  ILE A CD1 1 
ATOM   1907 N  N   . LEU A 1 242 ? -7.373  -44.468 3.983   1.00 10.50 ? 464  LEU A N   1 
ATOM   1908 C  CA  . LEU A 1 242 ? -7.892  -45.828 3.976   1.00 14.05 ? 464  LEU A CA  1 
ATOM   1909 C  C   . LEU A 1 242 ? -9.174  -45.909 4.790   1.00 15.35 ? 464  LEU A C   1 
ATOM   1910 O  O   . LEU A 1 242 ? -9.370  -45.136 5.721   1.00 14.18 ? 464  LEU A O   1 
ATOM   1911 C  CB  . LEU A 1 242 ? -6.874  -46.787 4.590   1.00 14.96 ? 464  LEU A CB  1 
ATOM   1912 C  CG  . LEU A 1 242 ? -5.441  -46.737 4.043   1.00 17.76 ? 464  LEU A CG  1 
ATOM   1913 C  CD1 . LEU A 1 242 ? -4.553  -47.649 4.859   1.00 17.83 ? 464  LEU A CD1 1 
ATOM   1914 C  CD2 . LEU A 1 242 ? -5.426  -47.125 2.575   1.00 17.64 ? 464  LEU A CD2 1 
ATOM   1915 N  N   . CYS A 1 243 ? -10.029 -46.880 4.468   1.00 13.04 ? 465  CYS A N   1 
ATOM   1916 C  CA  . CYS A 1 243 ? -11.111 -47.228 5.385   1.00 12.12 ? 465  CYS A CA  1 
ATOM   1917 C  C   . CYS A 1 243 ? -11.330 -48.732 5.342   1.00 12.94 ? 465  CYS A C   1 
ATOM   1918 O  O   . CYS A 1 243 ? -10.841 -49.428 4.451   1.00 11.97 ? 465  CYS A O   1 
ATOM   1919 C  CB  . CYS A 1 243 ? -12.412 -46.462 5.078   1.00 12.43 ? 465  CYS A CB  1 
ATOM   1920 S  SG  . CYS A 1 243 ? -13.207 -46.843 3.489   1.00 13.23 ? 465  CYS A SG  1 
ATOM   1921 N  N   . LEU A 1 244 ? -12.056 -49.238 6.335   1.00 11.01 ? 466  LEU A N   1 
ATOM   1922 C  CA  . LEU A 1 244 ? -12.312 -50.672 6.410   1.00 9.94  ? 466  LEU A CA  1 
ATOM   1923 C  C   . LEU A 1 244 ? -13.546 -51.099 5.628   1.00 10.46 ? 466  LEU A C   1 
ATOM   1924 O  O   . LEU A 1 244 ? -13.617 -52.255 5.193   1.00 10.99 ? 466  LEU A O   1 
ATOM   1925 C  CB  . LEU A 1 244 ? -12.481 -51.102 7.869   1.00 12.41 ? 466  LEU A CB  1 
ATOM   1926 C  CG  . LEU A 1 244 ? -11.219 -50.933 8.726   1.00 10.28 ? 466  LEU A CG  1 
ATOM   1927 C  CD1 . LEU A 1 244 ? -11.550 -51.190 10.197  1.00 13.38 ? 466  LEU A CD1 1 
ATOM   1928 C  CD2 . LEU A 1 244 ? -10.146 -51.891 8.239   1.00 11.43 ? 466  LEU A CD2 1 
ATOM   1929 N  N   . LEU A 1 245 ? -14.530 -50.196 5.473   1.00 11.70 ? 467  LEU A N   1 
ATOM   1930 C  CA  . LEU A 1 245 ? -15.778 -50.463 4.760   1.00 13.63 ? 467  LEU A CA  1 
ATOM   1931 C  C   . LEU A 1 245 ? -16.159 -49.185 4.026   1.00 12.19 ? 467  LEU A C   1 
ATOM   1932 O  O   . LEU A 1 245 ? -16.237 -48.123 4.657   1.00 12.25 ? 467  LEU A O   1 
ATOM   1933 C  CB  . LEU A 1 245 ? -16.910 -50.846 5.715   1.00 13.25 ? 467  LEU A CB  1 
ATOM   1934 C  CG  . LEU A 1 245 ? -16.772 -52.077 6.591   1.00 15.04 ? 467  LEU A CG  1 
ATOM   1935 C  CD1 . LEU A 1 245 ? -17.978 -52.107 7.545   1.00 13.82 ? 467  LEU A CD1 1 
ATOM   1936 C  CD2 . LEU A 1 245 ? -16.702 -53.318 5.728   1.00 13.34 ? 467  LEU A CD2 1 
ATOM   1937 N  N   . PRO A 1 246 ? -16.453 -49.239 2.731   1.00 11.71 ? 468  PRO A N   1 
ATOM   1938 C  CA  . PRO A 1 246 ? -17.054 -48.065 2.089   1.00 10.15 ? 468  PRO A CA  1 
ATOM   1939 C  C   . PRO A 1 246 ? -18.405 -47.762 2.725   1.00 11.23 ? 468  PRO A C   1 
ATOM   1940 O  O   . PRO A 1 246 ? -19.068 -48.646 3.268   1.00 12.44 ? 468  PRO A O   1 
ATOM   1941 C  CB  . PRO A 1 246 ? -17.199 -48.492 0.625   1.00 14.97 ? 468  PRO A CB  1 
ATOM   1942 C  CG  . PRO A 1 246 ? -16.172 -49.613 0.446   1.00 13.02 ? 468  PRO A CG  1 
ATOM   1943 C  CD  . PRO A 1 246 ? -16.216 -50.339 1.780   1.00 11.80 ? 468  PRO A CD  1 
ATOM   1944 N  N   . GLN A 1 247 ? -18.813 -46.490 2.662   1.00 11.06 ? 469  GLN A N   1 
ATOM   1945 C  CA  . GLN A 1 247 ? -20.029 -46.100 3.377   1.00 12.59 ? 469  GLN A CA  1 
ATOM   1946 C  C   . GLN A 1 247 ? -21.260 -46.831 2.844   1.00 12.22 ? 469  GLN A C   1 
ATOM   1947 O  O   . GLN A 1 247 ? -22.199 -47.113 3.603   1.00 11.49 ? 469  GLN A O   1 
ATOM   1948 C  CB  . GLN A 1 247 ? -20.228 -44.586 3.306   1.00 11.14 ? 469  GLN A CB  1 
ATOM   1949 C  CG  . GLN A 1 247 ? -21.402 -44.095 4.175   1.00 14.39 ? 469  GLN A CG  1 
ATOM   1950 C  CD  . GLN A 1 247 ? -21.157 -44.308 5.656   1.00 14.92 ? 469  GLN A CD  1 
ATOM   1951 O  OE1 . GLN A 1 247 ? -20.024 -44.216 6.127   1.00 17.68 ? 469  GLN A OE1 1 
ATOM   1952 N  NE2 . GLN A 1 247 ? -22.216 -44.620 6.395   1.00 14.19 ? 469  GLN A NE2 1 
ATOM   1953 N  N   . GLU A 1 248 ? -21.266 -47.188 1.560   1.00 11.54 ? 470  GLU A N   1 
ATOM   1954 C  CA  . GLU A 1 248 ? -22.430 -47.897 1.036   1.00 11.73 ? 470  GLU A CA  1 
ATOM   1955 C  C   . GLU A 1 248 ? -22.568 -49.287 1.640   1.00 12.25 ? 470  GLU A C   1 
ATOM   1956 O  O   . GLU A 1 248 ? -23.687 -49.803 1.744   1.00 12.21 ? 470  GLU A O   1 
ATOM   1957 C  CB  . GLU A 1 248 ? -22.359 -47.991 -0.485  1.00 11.58 ? 470  GLU A CB  1 
ATOM   1958 C  CG  . GLU A 1 248 ? -22.560 -46.651 -1.174  1.00 13.05 ? 470  GLU A CG  1 
ATOM   1959 C  CD  . GLU A 1 248 ? -21.336 -45.761 -1.116  1.00 15.42 ? 470  GLU A CD  1 
ATOM   1960 O  OE1 . GLU A 1 248 ? -20.236 -46.257 -0.801  1.00 12.92 ? 470  GLU A OE1 1 
ATOM   1961 O  OE2 . GLU A 1 248 ? -21.482 -44.551 -1.377  1.00 17.48 ? 470  GLU A OE2 1 
ATOM   1962 N  N   . MET A 1 249 ? -21.453 -49.914 2.029   1.00 11.76 ? 471  MET A N   1 
ATOM   1963 C  CA  . MET A 1 249 ? -21.558 -51.168 2.770   1.00 10.83 ? 471  MET A CA  1 
ATOM   1964 C  C   . MET A 1 249 ? -22.064 -50.925 4.181   1.00 10.88 ? 471  MET A C   1 
ATOM   1965 O  O   . MET A 1 249 ? -22.909 -51.679 4.677   1.00 13.29 ? 471  MET A O   1 
ATOM   1966 C  CB  . MET A 1 249 ? -20.204 -51.882 2.819   1.00 12.19 ? 471  MET A CB  1 
ATOM   1967 C  CG  . MET A 1 249 ? -19.740 -52.382 1.451   1.00 11.53 ? 471  MET A CG  1 
ATOM   1968 S  SD  . MET A 1 249 ? -18.348 -53.504 1.668   1.00 13.54 ? 471  MET A SD  1 
ATOM   1969 C  CE  . MET A 1 249 ? -17.821 -53.683 -0.043  1.00 14.25 ? 471  MET A CE  1 
ATOM   1970 N  N   . VAL A 1 250 ? -21.558 -49.882 4.846   1.00 11.33 ? 472  VAL A N   1 
ATOM   1971 C  CA  . VAL A 1 250 ? -22.086 -49.522 6.165   1.00 12.54 ? 472  VAL A CA  1 
ATOM   1972 C  C   . VAL A 1 250 ? -23.600 -49.354 6.096   1.00 14.21 ? 472  VAL A C   1 
ATOM   1973 O  O   . VAL A 1 250 ? -24.345 -49.944 6.891   1.00 13.09 ? 472  VAL A O   1 
ATOM   1974 C  CB  . VAL A 1 250 ? -21.408 -48.245 6.698   1.00 11.86 ? 472  VAL A CB  1 
ATOM   1975 C  CG1 . VAL A 1 250 ? -22.047 -47.819 8.024   1.00 12.18 ? 472  VAL A CG1 1 
ATOM   1976 C  CG2 . VAL A 1 250 ? -19.895 -48.442 6.860   1.00 12.08 ? 472  VAL A CG2 1 
ATOM   1977 N  N   . THR A 1 251 ? -24.078 -48.542 5.138   1.00 10.84 ? 473  THR A N   1 
ATOM   1978 C  CA  . THR A 1 251 ? -25.519 -48.298 5.021   1.00 11.47 ? 473  THR A CA  1 
ATOM   1979 C  C   . THR A 1 251 ? -26.278 -49.590 4.754   1.00 11.71 ? 473  THR A C   1 
ATOM   1980 O  O   . THR A 1 251 ? -27.338 -49.830 5.346   1.00 12.91 ? 473  THR A O   1 
ATOM   1981 C  CB  . THR A 1 251 ? -25.801 -47.286 3.910   1.00 12.49 ? 473  THR A CB  1 
ATOM   1982 O  OG1 . THR A 1 251 ? -25.154 -46.046 4.213   1.00 11.33 ? 473  THR A OG1 1 
ATOM   1983 C  CG2 . THR A 1 251 ? -27.310 -47.042 3.768   1.00 11.31 ? 473  THR A CG2 1 
ATOM   1984 N  N   . HIS A 1 252 ? -25.743 -50.441 3.872   1.00 12.22 ? 474  HIS A N   1 
ATOM   1985 C  CA  . HIS A 1 252 ? -26.398 -51.705 3.550   1.00 13.04 ? 474  HIS A CA  1 
ATOM   1986 C  C   . HIS A 1 252 ? -26.578 -52.575 4.791   1.00 15.42 ? 474  HIS A C   1 
ATOM   1987 O  O   . HIS A 1 252 ? -27.671 -53.090 5.044   1.00 11.99 ? 474  HIS A O   1 
ATOM   1988 C  CB  . HIS A 1 252 ? -25.589 -52.450 2.484   1.00 15.47 ? 474  HIS A CB  1 
ATOM   1989 C  CG  . HIS A 1 252 ? -26.310 -53.619 1.883   1.00 17.39 ? 474  HIS A CG  1 
ATOM   1990 N  ND1 . HIS A 1 252 ? -27.249 -53.482 0.881   1.00 16.04 ? 474  HIS A ND1 1 
ATOM   1991 C  CD2 . HIS A 1 252 ? -26.228 -54.947 2.144   1.00 15.70 ? 474  HIS A CD2 1 
ATOM   1992 C  CE1 . HIS A 1 252 ? -27.713 -54.677 0.551   1.00 21.92 ? 474  HIS A CE1 1 
ATOM   1993 N  NE2 . HIS A 1 252 ? -27.107 -55.583 1.300   1.00 17.94 ? 474  HIS A NE2 1 
ATOM   1994 N  N   . PHE A 1 253 ? -25.509 -52.755 5.579   1.00 13.37 ? 475  PHE A N   1 
ATOM   1995 C  CA  . PHE A 1 253 ? -25.615 -53.599 6.769   1.00 12.87 ? 475  PHE A CA  1 
ATOM   1996 C  C   . PHE A 1 253 ? -26.541 -52.970 7.802   1.00 11.95 ? 475  PHE A C   1 
ATOM   1997 O  O   . PHE A 1 253 ? -27.307 -53.669 8.474   1.00 14.82 ? 475  PHE A O   1 
ATOM   1998 C  CB  . PHE A 1 253 ? -24.234 -53.835 7.392   1.00 12.12 ? 475  PHE A CB  1 
ATOM   1999 C  CG  . PHE A 1 253 ? -23.213 -54.418 6.445   1.00 12.90 ? 475  PHE A CG  1 
ATOM   2000 C  CD1 . PHE A 1 253 ? -23.599 -55.187 5.349   1.00 12.71 ? 475  PHE A CD1 1 
ATOM   2001 C  CD2 . PHE A 1 253 ? -21.851 -54.194 6.659   1.00 16.24 ? 475  PHE A CD2 1 
ATOM   2002 C  CE1 . PHE A 1 253 ? -22.647 -55.707 4.477   1.00 15.77 ? 475  PHE A CE1 1 
ATOM   2003 C  CE2 . PHE A 1 253 ? -20.896 -54.715 5.797   1.00 12.86 ? 475  PHE A CE2 1 
ATOM   2004 C  CZ  . PHE A 1 253 ? -21.293 -55.470 4.696   1.00 13.58 ? 475  PHE A CZ  1 
ATOM   2005 N  N   . TYR A 1 254 ? -26.464 -51.650 7.947   1.00 11.81 ? 476  TYR A N   1 
ATOM   2006 C  CA  . TYR A 1 254 ? -27.336 -50.938 8.867   1.00 13.29 ? 476  TYR A CA  1 
ATOM   2007 C  C   . TYR A 1 254 ? -28.796 -51.093 8.473   1.00 15.54 ? 476  TYR A C   1 
ATOM   2008 O  O   . TYR A 1 254 ? -29.662 -51.292 9.333   1.00 15.68 ? 476  TYR A O   1 
ATOM   2009 C  CB  . TYR A 1 254 ? -26.951 -49.464 8.876   1.00 11.77 ? 476  TYR A CB  1 
ATOM   2010 C  CG  . TYR A 1 254 ? -27.818 -48.627 9.763   1.00 14.05 ? 476  TYR A CG  1 
ATOM   2011 C  CD1 . TYR A 1 254 ? -27.709 -48.722 11.137  1.00 14.71 ? 476  TYR A CD1 1 
ATOM   2012 C  CD2 . TYR A 1 254 ? -28.735 -47.731 9.226   1.00 16.54 ? 476  TYR A CD2 1 
ATOM   2013 C  CE1 . TYR A 1 254 ? -28.488 -47.944 11.964  1.00 19.71 ? 476  TYR A CE1 1 
ATOM   2014 C  CE2 . TYR A 1 254 ? -29.516 -46.943 10.050  1.00 19.60 ? 476  TYR A CE2 1 
ATOM   2015 C  CZ  . TYR A 1 254 ? -29.383 -47.057 11.415  1.00 25.35 ? 476  TYR A CZ  1 
ATOM   2016 O  OH  . TYR A 1 254 ? -30.157 -46.286 12.249  1.00 33.01 ? 476  TYR A OH  1 
ATOM   2017 N  N   . GLU A 1 255 ? -29.082 -51.016 7.170   1.00 12.85 ? 477  GLU A N   1 
ATOM   2018 C  CA  . GLU A 1 255 ? -30.465 -51.050 6.707   1.00 15.59 ? 477  GLU A CA  1 
ATOM   2019 C  C   . GLU A 1 255 ? -31.060 -52.452 6.810   1.00 19.53 ? 477  GLU A C   1 
ATOM   2020 O  O   . GLU A 1 255 ? -32.238 -52.605 7.145   1.00 18.13 ? 477  GLU A O   1 
ATOM   2021 C  CB  . GLU A 1 255 ? -30.525 -50.522 5.267   1.00 17.19 ? 477  GLU A CB  1 
ATOM   2022 C  CG  . GLU A 1 255 ? -31.920 -50.293 4.683   1.00 22.20 ? 477  GLU A CG  1 
ATOM   2023 C  CD  . GLU A 1 255 ? -32.513 -51.536 4.013   1.00 31.06 ? 477  GLU A CD  1 
ATOM   2024 O  OE1 . GLU A 1 255 ? -31.752 -52.478 3.701   1.00 25.10 ? 477  GLU A OE1 1 
ATOM   2025 O  OE2 . GLU A 1 255 ? -33.748 -51.576 3.801   1.00 21.40 ? 477  GLU A OE2 1 
ATOM   2026 N  N   . GLN A 1 256 ? -30.266 -53.490 6.542   1.00 13.86 ? 478  GLN A N   1 
ATOM   2027 C  CA  A GLN A 1 256 ? -30.776 -54.857 6.473   0.58 17.53 ? 478  GLN A CA  1 
ATOM   2028 C  CA  B GLN A 1 256 ? -30.834 -54.831 6.485   0.42 17.56 ? 478  GLN A CA  1 
ATOM   2029 C  C   . GLN A 1 256 ? -30.870 -55.516 7.844   1.00 20.68 ? 478  GLN A C   1 
ATOM   2030 O  O   . GLN A 1 256 ? -31.751 -56.352 8.067   1.00 19.67 ? 478  GLN A O   1 
ATOM   2031 C  CB  A GLN A 1 256 ? -29.885 -55.696 5.550   0.58 18.50 ? 478  GLN A CB  1 
ATOM   2032 C  CB  B GLN A 1 256 ? -30.078 -55.710 5.474   0.42 18.95 ? 478  GLN A CB  1 
ATOM   2033 C  CG  A GLN A 1 256 ? -29.972 -55.295 4.079   0.58 16.28 ? 478  GLN A CG  1 
ATOM   2034 C  CG  B GLN A 1 256 ? -28.638 -55.980 5.815   0.42 14.55 ? 478  GLN A CG  1 
ATOM   2035 C  CD  A GLN A 1 256 ? -31.219 -55.835 3.404   0.58 24.01 ? 478  GLN A CD  1 
ATOM   2036 C  CD  B GLN A 1 256 ? -27.971 -57.006 4.902   0.42 22.19 ? 478  GLN A CD  1 
ATOM   2037 O  OE1 A GLN A 1 256 ? -31.420 -57.043 3.340   0.58 18.06 ? 478  GLN A OE1 1 
ATOM   2038 O  OE1 B GLN A 1 256 ? -26.801 -57.364 5.096   0.42 9.29  ? 478  GLN A OE1 1 
ATOM   2039 N  NE2 A GLN A 1 256 ? -32.058 -54.941 2.891   0.58 20.14 ? 478  GLN A NE2 1 
ATOM   2040 N  NE2 B GLN A 1 256 ? -28.711 -57.486 3.907   0.42 22.03 ? 478  GLN A NE2 1 
ATOM   2041 N  N   . GLN A 1 257 ? -29.962 -55.177 8.761   1.00 17.56 ? 479  GLN A N   1 
ATOM   2042 C  CA  . GLN A 1 257 ? -29.950 -55.756 10.111  1.00 15.78 ? 479  GLN A CA  1 
ATOM   2043 C  C   . GLN A 1 257 ? -30.017 -57.287 10.064  1.00 23.24 ? 479  GLN A C   1 
ATOM   2044 O  O   . GLN A 1 257 ? -30.788 -57.929 10.780  1.00 22.19 ? 479  GLN A O   1 
ATOM   2045 C  CB  . GLN A 1 257 ? -31.091 -55.181 10.956  1.00 18.92 ? 479  GLN A CB  1 
ATOM   2046 C  CG  . GLN A 1 257 ? -31.027 -53.660 11.142  1.00 21.57 ? 479  GLN A CG  1 
ATOM   2047 C  CD  . GLN A 1 257 ? -30.031 -53.247 12.218  1.00 30.41 ? 479  GLN A CD  1 
ATOM   2048 O  OE1 . GLN A 1 257 ? -29.961 -53.874 13.276  1.00 29.66 ? 479  GLN A OE1 1 
ATOM   2049 N  NE2 . GLN A 1 257 ? -29.255 -52.185 11.953  1.00 22.12 ? 479  GLN A NE2 1 
ATOM   2050 N  N   . ALA A 1 258 ? -29.185 -57.875 9.216   1.00 16.64 ? 480  ALA A N   1 
ATOM   2051 C  CA  . ALA A 1 258 ? -29.228 -59.316 8.997   1.00 17.52 ? 480  ALA A CA  1 
ATOM   2052 C  C   . ALA A 1 258 ? -28.443 -60.041 10.085  1.00 22.16 ? 480  ALA A C   1 
ATOM   2053 O  O   . ALA A 1 258 ? -27.264 -59.736 10.293  1.00 17.68 ? 480  ALA A O   1 
ATOM   2054 C  CB  . ALA A 1 258 ? -28.669 -59.656 7.622   1.00 15.43 ? 480  ALA A CB  1 
ATOM   2055 N  N   . PRO A 1 259 ? -29.049 -60.984 10.803  1.00 21.28 ? 481  PRO A N   1 
ATOM   2056 C  CA  . PRO A 1 259 ? -28.296 -61.730 11.817  1.00 18.99 ? 481  PRO A CA  1 
ATOM   2057 C  C   . PRO A 1 259 ? -27.120 -62.482 11.209  1.00 16.13 ? 481  PRO A C   1 
ATOM   2058 O  O   . PRO A 1 259 ? -27.215 -63.050 10.120  1.00 19.61 ? 481  PRO A O   1 
ATOM   2059 C  CB  . PRO A 1 259 ? -29.340 -62.699 12.391  1.00 24.69 ? 481  PRO A CB  1 
ATOM   2060 C  CG  . PRO A 1 259 ? -30.654 -62.029 12.142  1.00 24.72 ? 481  PRO A CG  1 
ATOM   2061 C  CD  . PRO A 1 259 ? -30.488 -61.301 10.827  1.00 24.83 ? 481  PRO A CD  1 
ATOM   2062 N  N   . SER A 1 260 ? -26.005 -62.497 11.938  1.00 17.80 ? 482  SER A N   1 
ATOM   2063 C  CA  . SER A 1 260 ? -24.840 -63.259 11.513  1.00 18.05 ? 482  SER A CA  1 
ATOM   2064 C  C   . SER A 1 260 ? -25.036 -64.715 11.909  1.00 21.70 ? 482  SER A C   1 
ATOM   2065 O  O   . SER A 1 260 ? -25.419 -65.009 13.045  1.00 24.50 ? 482  SER A O   1 
ATOM   2066 C  CB  . SER A 1 260 ? -23.565 -62.696 12.142  1.00 18.66 ? 482  SER A CB  1 
ATOM   2067 O  OG  . SER A 1 260 ? -23.416 -61.310 11.850  1.00 20.54 ? 482  SER A OG  1 
ATOM   2068 N  N   . GLN A 1 261 ? -24.797 -65.624 10.972  1.00 16.23 ? 483  GLN A N   1 
ATOM   2069 C  CA  . GLN A 1 261 ? -25.122 -67.031 11.178  1.00 16.69 ? 483  GLN A CA  1 
ATOM   2070 C  C   . GLN A 1 261 ? -23.890 -67.928 11.097  1.00 24.63 ? 483  GLN A C   1 
ATOM   2071 O  O   . GLN A 1 261 ? -23.974 -69.076 10.653  1.00 27.06 ? 483  GLN A O   1 
ATOM   2072 C  CB  . GLN A 1 261 ? -26.189 -67.475 10.182  1.00 21.86 ? 483  GLN A CB  1 
ATOM   2073 C  CG  . GLN A 1 261 ? -27.430 -66.605 10.263  1.00 19.29 ? 483  GLN A CG  1 
ATOM   2074 C  CD  . GLN A 1 261 ? -28.697 -67.342 9.907   1.00 45.09 ? 483  GLN A CD  1 
ATOM   2075 O  OE1 . GLN A 1 261 ? -28.838 -68.532 10.189  1.00 46.95 ? 483  GLN A OE1 1 
ATOM   2076 N  NE2 . GLN A 1 261 ? -29.634 -66.636 9.284   1.00 32.15 ? 483  GLN A NE2 1 
ATOM   2077 N  N   . GLY A 1 262 ? -22.745 -67.422 11.529  1.00 20.62 ? 484  GLY A N   1 
ATOM   2078 C  CA  . GLY A 1 262 ? -21.532 -68.222 11.568  1.00 20.17 ? 484  GLY A CA  1 
ATOM   2079 C  C   . GLY A 1 262 ? -20.392 -67.377 12.094  1.00 20.62 ? 484  GLY A C   1 
ATOM   2080 O  O   . GLY A 1 262 ? -20.565 -66.198 12.417  1.00 19.75 ? 484  GLY A O   1 
ATOM   2081 N  N   . ASP A 1 263 ? -19.206 -67.998 12.184  1.00 16.75 ? 485  ASP A N   1 
ATOM   2082 C  CA  . ASP A 1 263 ? -18.067 -67.289 12.768  1.00 17.99 ? 485  ASP A CA  1 
ATOM   2083 C  C   . ASP A 1 263 ? -17.627 -66.111 11.904  1.00 17.32 ? 485  ASP A C   1 
ATOM   2084 O  O   . ASP A 1 263 ? -17.299 -65.034 12.426  1.00 18.10 ? 485  ASP A O   1 
ATOM   2085 C  CB  . ASP A 1 263 ? -16.890 -68.238 12.969  1.00 15.81 ? 485  ASP A CB  1 
ATOM   2086 C  CG  . ASP A 1 263 ? -17.128 -69.244 14.076  1.00 18.36 ? 485  ASP A CG  1 
ATOM   2087 O  OD1 . ASP A 1 263 ? -18.110 -69.082 14.826  1.00 20.08 ? 485  ASP A OD1 1 
ATOM   2088 O  OD2 . ASP A 1 263 ? -16.324 -70.194 14.182  1.00 18.40 ? 485  ASP A OD2 1 
ATOM   2089 N  N   . VAL A 1 264 ? -17.587 -66.304 10.589  1.00 14.57 ? 486  VAL A N   1 
ATOM   2090 C  CA  . VAL A 1 264 ? -17.049 -65.291 9.686   1.00 14.08 ? 486  VAL A CA  1 
ATOM   2091 C  C   . VAL A 1 264 ? -17.685 -65.509 8.320   1.00 14.47 ? 486  VAL A C   1 
ATOM   2092 O  O   . VAL A 1 264 ? -18.122 -66.615 7.992   1.00 18.22 ? 486  VAL A O   1 
ATOM   2093 C  CB  . VAL A 1 264 ? -15.498 -65.361 9.663   1.00 19.51 ? 486  VAL A CB  1 
ATOM   2094 C  CG1 . VAL A 1 264 ? -15.020 -66.698 9.122   1.00 19.86 ? 486  VAL A CG1 1 
ATOM   2095 C  CG2 . VAL A 1 264 ? -14.892 -64.200 8.884   1.00 17.96 ? 486  VAL A CG2 1 
ATOM   2096 N  N   . ALA A 1 265 ? -17.798 -64.434 7.540   1.00 13.75 ? 487  ALA A N   1 
ATOM   2097 C  CA  . ALA A 1 265 ? -18.448 -64.508 6.239   1.00 14.70 ? 487  ALA A CA  1 
ATOM   2098 C  C   . ALA A 1 265 ? -17.409 -64.736 5.151   1.00 19.58 ? 487  ALA A C   1 
ATOM   2099 O  O   . ALA A 1 265 ? -16.404 -64.017 5.081   1.00 18.12 ? 487  ALA A O   1 
ATOM   2100 C  CB  . ALA A 1 265 ? -19.236 -63.221 5.965   1.00 13.28 ? 487  ALA A CB  1 
ATOM   2101 N  N   . LEU A 1 266 ? -17.645 -65.735 4.301   1.00 13.52 ? 488  LEU A N   1 
ATOM   2102 C  CA  . LEU A 1 266 ? -16.791 -65.961 3.140   1.00 13.00 ? 488  LEU A CA  1 
ATOM   2103 C  C   . LEU A 1 266 ? -17.330 -65.156 1.965   1.00 16.56 ? 488  LEU A C   1 
ATOM   2104 O  O   . LEU A 1 266 ? -18.495 -65.314 1.586   1.00 17.54 ? 488  LEU A O   1 
ATOM   2105 C  CB  . LEU A 1 266 ? -16.731 -67.443 2.786   1.00 13.78 ? 488  LEU A CB  1 
ATOM   2106 C  CG  . LEU A 1 266 ? -15.910 -67.851 1.555   1.00 16.02 ? 488  LEU A CG  1 
ATOM   2107 C  CD1 . LEU A 1 266 ? -14.432 -67.433 1.665   1.00 16.92 ? 488  LEU A CD1 1 
ATOM   2108 C  CD2 . LEU A 1 266 ? -16.028 -69.362 1.350   1.00 20.51 ? 488  LEU A CD2 1 
ATOM   2109 N  N   . VAL A 1 267 ? -16.489 -64.302 1.389   1.00 14.92 ? 489  VAL A N   1 
ATOM   2110 C  CA  . VAL A 1 267 ? -16.905 -63.432 0.296   1.00 13.48 ? 489  VAL A CA  1 
ATOM   2111 C  C   . VAL A 1 267 ? -15.962 -63.630 -0.875  1.00 15.61 ? 489  VAL A C   1 
ATOM   2112 O  O   . VAL A 1 267 ? -14.780 -63.935 -0.699  1.00 16.50 ? 489  VAL A O   1 
ATOM   2113 C  CB  . VAL A 1 267 ? -16.934 -61.949 0.713   1.00 13.49 ? 489  VAL A CB  1 
ATOM   2114 C  CG1 . VAL A 1 267 ? -17.955 -61.735 1.835   1.00 13.65 ? 489  VAL A CG1 1 
ATOM   2115 C  CG2 . VAL A 1 267 ? -15.527 -61.487 1.140   1.00 15.48 ? 489  VAL A CG2 1 
ATOM   2116 N  N   . ARG A 1 268 ? -16.488 -63.446 -2.081  1.00 14.17 ? 490  ARG A N   1 
ATOM   2117 C  CA  . ARG A 1 268 ? -15.698 -63.543 -3.299  1.00 15.59 ? 490  ARG A CA  1 
ATOM   2118 C  C   . ARG A 1 268 ? -15.758 -62.210 -4.034  1.00 17.53 ? 490  ARG A C   1 
ATOM   2119 O  O   . ARG A 1 268 ? -16.808 -61.562 -4.076  1.00 15.49 ? 490  ARG A O   1 
ATOM   2120 C  CB  . ARG A 1 268 ? -16.205 -64.682 -4.205  1.00 17.56 ? 490  ARG A CB  1 
ATOM   2121 C  CG  . ARG A 1 268 ? -15.540 -66.040 -3.941  1.00 18.35 ? 490  ARG A CG  1 
ATOM   2122 C  CD  . ARG A 1 268 ? -15.831 -66.561 -2.526  1.00 23.87 ? 490  ARG A CD  1 
ATOM   2123 N  NE  . ARG A 1 268 ? -15.225 -67.873 -2.302  1.00 22.35 ? 490  ARG A NE  1 
ATOM   2124 C  CZ  . ARG A 1 268 ? -15.853 -69.028 -2.483  1.00 26.59 ? 490  ARG A CZ  1 
ATOM   2125 N  NH1 . ARG A 1 268 ? -17.134 -69.075 -2.809  1.00 23.83 ? 490  ARG A NH1 1 
ATOM   2126 N  NH2 . ARG A 1 268 ? -15.179 -70.164 -2.337  1.00 22.51 ? 490  ARG A NH2 1 
ATOM   2127 N  N   . TYR A 1 269 ? -14.621 -61.783 -4.573  1.00 14.45 ? 491  TYR A N   1 
ATOM   2128 C  CA  . TYR A 1 269 ? -14.562 -60.565 -5.370  1.00 15.24 ? 491  TYR A CA  1 
ATOM   2129 C  C   . TYR A 1 269 ? -14.730 -60.969 -6.825  1.00 15.31 ? 491  TYR A C   1 
ATOM   2130 O  O   . TYR A 1 269 ? -13.965 -61.799 -7.332  1.00 17.38 ? 491  TYR A O   1 
ATOM   2131 C  CB  . TYR A 1 269 ? -13.240 -59.832 -5.161  1.00 15.02 ? 491  TYR A CB  1 
ATOM   2132 C  CG  . TYR A 1 269 ? -13.170 -58.451 -5.781  1.00 15.45 ? 491  TYR A CG  1 
ATOM   2133 C  CD1 . TYR A 1 269 ? -13.890 -57.393 -5.248  1.00 15.55 ? 491  TYR A CD1 1 
ATOM   2134 C  CD2 . TYR A 1 269 ? -12.352 -58.201 -6.882  1.00 18.04 ? 491  TYR A CD2 1 
ATOM   2135 C  CE1 . TYR A 1 269 ? -13.814 -56.119 -5.811  1.00 14.92 ? 491  TYR A CE1 1 
ATOM   2136 C  CE2 . TYR A 1 269 ? -12.262 -56.930 -7.444  1.00 16.20 ? 491  TYR A CE2 1 
ATOM   2137 C  CZ  . TYR A 1 269 ? -12.997 -55.899 -6.903  1.00 17.57 ? 491  TYR A CZ  1 
ATOM   2138 O  OH  . TYR A 1 269 ? -12.911 -54.646 -7.451  1.00 17.56 ? 491  TYR A OH  1 
ATOM   2139 N  N   . ILE A 1 270 ? -15.739 -60.400 -7.478  1.00 16.74 ? 492  ILE A N   1 
ATOM   2140 C  CA  . ILE A 1 270 ? -16.168 -60.814 -8.810  1.00 18.52 ? 492  ILE A CA  1 
ATOM   2141 C  C   . ILE A 1 270 ? -15.835 -59.697 -9.786  1.00 20.40 ? 492  ILE A C   1 
ATOM   2142 O  O   . ILE A 1 270 ? -16.241 -58.551 -9.571  1.00 19.93 ? 492  ILE A O   1 
ATOM   2143 C  CB  . ILE A 1 270 ? -17.678 -61.109 -8.841  1.00 17.04 ? 492  ILE A CB  1 
ATOM   2144 C  CG1 . ILE A 1 270 ? -18.096 -62.070 -7.714  1.00 17.91 ? 492  ILE A CG1 1 
ATOM   2145 C  CG2 . ILE A 1 270 ? -18.104 -61.607 -10.241 1.00 19.63 ? 492  ILE A CG2 1 
ATOM   2146 C  CD1 . ILE A 1 270 ? -17.409 -63.409 -7.733  1.00 21.17 ? 492  ILE A CD1 1 
ATOM   2147 N  N   . ASN A 1 271 ? -15.118 -60.030 -10.863 1.00 19.36 ? 493  ASN A N   1 
ATOM   2148 C  CA  . ASN A 1 271 ? -14.869 -59.050 -11.914 1.00 23.52 ? 493  ASN A CA  1 
ATOM   2149 C  C   . ASN A 1 271 ? -16.187 -58.624 -12.556 1.00 25.25 ? 493  ASN A C   1 
ATOM   2150 O  O   . ASN A 1 271 ? -17.001 -59.464 -12.951 1.00 24.36 ? 493  ASN A O   1 
ATOM   2151 C  CB  . ASN A 1 271 ? -13.922 -59.627 -12.968 1.00 25.08 ? 493  ASN A CB  1 
ATOM   2152 C  CG  . ASN A 1 271 ? -13.522 -58.599 -14.013 1.00 32.30 ? 493  ASN A CG  1 
ATOM   2153 O  OD1 . ASN A 1 271 ? -14.238 -58.383 -14.983 1.00 26.91 ? 493  ASN A OD1 1 
ATOM   2154 N  ND2 . ASN A 1 271 ? -12.382 -57.954 -13.808 1.00 30.26 ? 493  ASN A ND2 1 
ATOM   2155 N  N   . ALA A 1 272 ? -16.406 -57.309 -12.650 1.00 23.72 ? 494  ALA A N   1 
ATOM   2156 C  CA  . ALA A 1 272 ? -17.699 -56.817 -13.123 1.00 26.52 ? 494  ALA A CA  1 
ATOM   2157 C  C   . ALA A 1 272 ? -17.911 -57.114 -14.603 1.00 28.02 ? 494  ALA A C   1 
ATOM   2158 O  O   . ALA A 1 272 ? -19.044 -57.363 -15.029 1.00 39.45 ? 494  ALA A O   1 
ATOM   2159 C  CB  . ALA A 1 272 ? -17.825 -55.316 -12.873 1.00 28.48 ? 494  ALA A CB  1 
ATOM   2160 N  N   . GLU A 1 273 ? -16.840 -57.094 -15.391 1.00 25.07 ? 495  GLU A N   1 
ATOM   2161 C  CA  . GLU A 1 273 ? -16.962 -57.357 -16.820 1.00 30.94 ? 495  GLU A CA  1 
ATOM   2162 C  C   . GLU A 1 273 ? -17.202 -58.837 -17.088 1.00 38.40 ? 495  GLU A C   1 
ATOM   2163 O  O   . GLU A 1 273 ? -18.195 -59.216 -17.719 1.00 47.27 ? 495  GLU A O   1 
ATOM   2164 C  CB  . GLU A 1 273 ? -15.700 -56.879 -17.535 1.00 35.54 ? 495  GLU A CB  1 
ATOM   2165 C  CG  . GLU A 1 273 ? -15.808 -56.838 -19.046 1.00 53.32 ? 495  GLU A CG  1 
ATOM   2166 C  CD  . GLU A 1 273 ? -14.536 -56.329 -19.692 1.00 77.33 ? 495  GLU A CD  1 
ATOM   2167 O  OE1 . GLU A 1 273 ? -13.440 -56.740 -19.255 1.00 73.99 ? 495  GLU A OE1 1 
ATOM   2168 O  OE2 . GLU A 1 273 ? -14.630 -55.508 -20.629 1.00 97.04 ? 495  GLU A OE2 1 
ATOM   2169 N  N   . THR A 1 274 ? -16.298 -59.693 -16.608 1.00 34.18 ? 496  THR A N   1 
ATOM   2170 C  CA  . THR A 1 274 ? -16.315 -61.103 -16.971 1.00 31.02 ? 496  THR A CA  1 
ATOM   2171 C  C   . THR A 1 274 ? -17.130 -61.969 -16.026 1.00 44.45 ? 496  THR A C   1 
ATOM   2172 O  O   . THR A 1 274 ? -17.517 -63.078 -16.405 1.00 34.31 ? 496  THR A O   1 
ATOM   2173 C  CB  . THR A 1 274 ? -14.885 -61.644 -17.033 1.00 31.48 ? 496  THR A CB  1 
ATOM   2174 O  OG1 . THR A 1 274 ? -14.334 -61.715 -15.712 1.00 38.88 ? 496  THR A OG1 1 
ATOM   2175 C  CG2 . THR A 1 274 ? -14.014 -60.728 -17.872 1.00 42.16 ? 496  THR A CG2 1 
ATOM   2176 N  N   . GLY A 1 275 ? -17.403 -61.505 -14.812 1.00 28.05 ? 497  GLY A N   1 
ATOM   2177 C  CA  . GLY A 1 275 ? -18.003 -62.362 -13.819 1.00 26.40 ? 497  GLY A CA  1 
ATOM   2178 C  C   . GLY A 1 275 ? -17.046 -63.358 -13.199 1.00 21.76 ? 497  GLY A C   1 
ATOM   2179 O  O   . GLY A 1 275 ? -17.485 -64.193 -12.401 1.00 29.61 ? 497  GLY A O   1 
ATOM   2180 N  N   . ARG A 1 276 ? -15.758 -63.292 -13.535 0.89 25.30 ? 498  ARG A N   1 
ATOM   2181 C  CA  . ARG A 1 276 ? -14.786 -64.226 -12.987 0.89 25.44 ? 498  ARG A CA  1 
ATOM   2182 C  C   . ARG A 1 276 ? -14.553 -63.941 -11.507 0.89 23.60 ? 498  ARG A C   1 
ATOM   2183 O  O   . ARG A 1 276 ? -14.508 -62.784 -11.085 0.89 20.47 ? 498  ARG A O   1 
ATOM   2184 C  CB  . ARG A 1 276 ? -13.467 -64.123 -13.749 0.89 30.32 ? 498  ARG A CB  1 
ATOM   2185 C  CG  . ARG A 1 276 ? -12.412 -65.126 -13.313 0.89 39.26 ? 498  ARG A CG  1 
ATOM   2186 C  CD  . ARG A 1 276 ? -11.128 -65.009 -14.127 0.89 52.36 ? 498  ARG A CD  1 
ATOM   2187 N  NE  . ARG A 1 276 ? -10.257 -63.942 -13.647 0.89 54.30 ? 498  ARG A NE  1 
ATOM   2188 C  CZ  . ARG A 1 276 ? -9.401  -64.071 -12.641 0.89 57.75 ? 498  ARG A CZ  1 
ATOM   2189 N  NH1 . ARG A 1 276 ? -9.287  -65.208 -11.969 0.89 47.24 ? 498  ARG A NH1 1 
ATOM   2190 N  NH2 . ARG A 1 276 ? -8.643  -63.031 -12.298 0.89 48.88 ? 498  ARG A NH2 1 
ATOM   2191 N  N   . VAL A 1 277 ? -14.409 -65.006 -10.721 1.00 24.83 ? 499  VAL A N   1 
ATOM   2192 C  CA  . VAL A 1 277 ? -13.976 -64.870 -9.335  1.00 21.54 ? 499  VAL A CA  1 
ATOM   2193 C  C   . VAL A 1 277 ? -12.499 -64.509 -9.334  1.00 23.35 ? 499  VAL A C   1 
ATOM   2194 O  O   . VAL A 1 277 ? -11.660 -65.271 -9.829  1.00 21.21 ? 499  VAL A O   1 
ATOM   2195 C  CB  . VAL A 1 277 ? -14.224 -66.164 -8.547  1.00 19.64 ? 499  VAL A CB  1 
ATOM   2196 C  CG1 . VAL A 1 277 ? -13.613 -66.050 -7.156  1.00 19.93 ? 499  VAL A CG1 1 
ATOM   2197 C  CG2 . VAL A 1 277 ? -15.713 -66.455 -8.443  1.00 20.72 ? 499  VAL A CG2 1 
ATOM   2198 N  N   . MET A 1 278 ? -12.169 -63.353 -8.762  1.00 18.24 ? 500  MET A N   1 
ATOM   2199 C  CA  A MET A 1 278 ? -10.782 -62.915 -8.767  0.43 20.78 ? 500  MET A CA  1 
ATOM   2200 C  CA  B MET A 1 278 ? -10.795 -62.862 -8.737  0.57 20.74 ? 500  MET A CA  1 
ATOM   2201 C  C   . MET A 1 278 ? -10.030 -63.357 -7.518  1.00 16.53 ? 500  MET A C   1 
ATOM   2202 O  O   . MET A 1 278 ? -8.850  -63.709 -7.613  1.00 20.26 ? 500  MET A O   1 
ATOM   2203 C  CB  A MET A 1 278 ? -10.710 -61.396 -8.929  0.43 22.08 ? 500  MET A CB  1 
ATOM   2204 C  CB  B MET A 1 278 ? -10.785 -61.332 -8.753  0.57 22.28 ? 500  MET A CB  1 
ATOM   2205 C  CG  A MET A 1 278 ? -11.522 -60.887 -10.109 0.43 24.46 ? 500  MET A CG  1 
ATOM   2206 C  CG  B MET A 1 278 ? -11.566 -60.733 -9.898  0.57 24.86 ? 500  MET A CG  1 
ATOM   2207 S  SD  A MET A 1 278 ? -11.306 -59.127 -10.398 0.43 25.71 ? 500  MET A SD  1 
ATOM   2208 S  SD  B MET A 1 278 ? -10.699 -61.036 -11.431 0.57 28.73 ? 500  MET A SD  1 
ATOM   2209 C  CE  A MET A 1 278 ? -9.644  -59.102 -11.060 0.43 34.16 ? 500  MET A CE  1 
ATOM   2210 C  CE  B MET A 1 278 ? -9.339  -59.881 -11.271 0.57 33.40 ? 500  MET A CE  1 
ATOM   2211 N  N   . PHE A 1 279 ? -10.678 -63.345 -6.361  1.00 16.40 ? 501  PHE A N   1 
ATOM   2212 C  CA  . PHE A 1 279 ? -10.080 -63.814 -5.115  1.00 14.98 ? 501  PHE A CA  1 
ATOM   2213 C  C   . PHE A 1 279 ? -11.209 -63.926 -4.105  1.00 16.17 ? 501  PHE A C   1 
ATOM   2214 O  O   . PHE A 1 279 ? -12.337 -63.495 -4.359  1.00 18.29 ? 501  PHE A O   1 
ATOM   2215 C  CB  . PHE A 1 279 ? -8.955  -62.891 -4.613  1.00 18.29 ? 501  PHE A CB  1 
ATOM   2216 C  CG  . PHE A 1 279 ? -9.400  -61.481 -4.282  1.00 18.41 ? 501  PHE A CG  1 
ATOM   2217 C  CD1 . PHE A 1 279 ? -9.874  -61.164 -3.011  1.00 17.21 ? 501  PHE A CD1 1 
ATOM   2218 C  CD2 . PHE A 1 279 ? -9.324  -60.474 -5.239  1.00 18.96 ? 501  PHE A CD2 1 
ATOM   2219 C  CE1 . PHE A 1 279 ? -10.274 -59.864 -2.702  1.00 17.08 ? 501  PHE A CE1 1 
ATOM   2220 C  CE2 . PHE A 1 279 ? -9.720  -59.187 -4.940  1.00 18.66 ? 501  PHE A CE2 1 
ATOM   2221 C  CZ  . PHE A 1 279 ? -10.195 -58.881 -3.664  1.00 15.27 ? 501  PHE A CZ  1 
ATOM   2222 N  N   . GLU A 1 280 ? -10.908 -64.531 -2.965  1.00 16.57 ? 502  GLU A N   1 
ATOM   2223 C  CA  . GLU A 1 280 ? -11.875 -64.605 -1.886  1.00 15.91 ? 502  GLU A CA  1 
ATOM   2224 C  C   . GLU A 1 280 ? -11.271 -63.991 -0.629  1.00 14.79 ? 502  GLU A C   1 
ATOM   2225 O  O   . GLU A 1 280 ? -10.057 -63.790 -0.524  1.00 14.66 ? 502  GLU A O   1 
ATOM   2226 C  CB  . GLU A 1 280 ? -12.321 -66.053 -1.633  1.00 17.32 ? 502  GLU A CB  1 
ATOM   2227 C  CG  . GLU A 1 280 ? -11.192 -66.996 -1.260  1.00 19.80 ? 502  GLU A CG  1 
ATOM   2228 C  CD  . GLU A 1 280 ? -11.666 -68.436 -1.101  1.00 26.72 ? 502  GLU A CD  1 
ATOM   2229 O  OE1 . GLU A 1 280 ? -12.630 -68.831 -1.791  1.00 26.43 ? 502  GLU A OE1 1 
ATOM   2230 O  OE2 . GLU A 1 280 ? -11.079 -69.170 -0.285  1.00 19.48 ? 502  GLU A OE2 1 
ATOM   2231 N  N   . GLY A 1 281 ? -12.143 -63.663 0.316   1.00 14.47 ? 503  GLY A N   1 
ATOM   2232 C  CA  . GLY A 1 281 ? -11.690 -63.090 1.567   1.00 12.22 ? 503  GLY A CA  1 
ATOM   2233 C  C   . GLY A 1 281 ? -12.655 -63.435 2.674   1.00 12.39 ? 503  GLY A C   1 
ATOM   2234 O  O   . GLY A 1 281 ? -13.722 -64.011 2.447   1.00 14.49 ? 503  GLY A O   1 
ATOM   2235 N  N   . LYS A 1 282 ? -12.254 -63.078 3.892   1.00 12.39 ? 504  LYS A N   1 
ATOM   2236 C  CA  . LYS A 1 282 ? -13.112 -63.175 5.058   1.00 11.28 ? 504  LYS A CA  1 
ATOM   2237 C  C   . LYS A 1 282 ? -13.672 -61.800 5.352   1.00 14.45 ? 504  LYS A C   1 
ATOM   2238 O  O   . LYS A 1 282 ? -12.927 -60.817 5.386   1.00 14.15 ? 504  LYS A O   1 
ATOM   2239 C  CB  . LYS A 1 282 ? -12.349 -63.685 6.285   1.00 11.79 ? 504  LYS A CB  1 
ATOM   2240 C  CG  . LYS A 1 282 ? -12.151 -65.185 6.309   1.00 12.60 ? 504  LYS A CG  1 
ATOM   2241 C  CD  . LYS A 1 282 ? -11.185 -65.562 7.427   1.00 14.32 ? 504  LYS A CD  1 
ATOM   2242 C  CE  . LYS A 1 282 ? -10.847 -67.043 7.383   1.00 15.22 ? 504  LYS A CE  1 
ATOM   2243 N  NZ  . LYS A 1 282 ? -9.668  -67.336 8.284   1.00 14.79 ? 504  LYS A NZ  1 
ATOM   2244 N  N   . LEU A 1 283 ? -14.970 -61.735 5.567   1.00 11.51 ? 505  LEU A N   1 
ATOM   2245 C  CA  . LEU A 1 283 ? -15.616 -60.523 6.040   1.00 12.37 ? 505  LEU A CA  1 
ATOM   2246 C  C   . LEU A 1 283 ? -16.001 -60.782 7.488   1.00 12.68 ? 505  LEU A C   1 
ATOM   2247 O  O   . LEU A 1 283 ? -16.868 -61.618 7.770   1.00 12.92 ? 505  LEU A O   1 
ATOM   2248 C  CB  . LEU A 1 283 ? -16.821 -60.171 5.166   1.00 13.46 ? 505  LEU A CB  1 
ATOM   2249 C  CG  . LEU A 1 283 ? -17.629 -58.944 5.579   1.00 11.49 ? 505  LEU A CG  1 
ATOM   2250 C  CD1 . LEU A 1 283 ? -16.753 -57.706 5.766   1.00 12.52 ? 505  LEU A CD1 1 
ATOM   2251 C  CD2 . LEU A 1 283 ? -18.750 -58.686 4.546   1.00 12.02 ? 505  LEU A CD2 1 
ATOM   2252 N  N   . HIS A 1 284 ? -15.340 -60.081 8.401   1.00 12.09 ? 506  HIS A N   1 
ATOM   2253 C  CA  . HIS A 1 284 ? -15.458 -60.371 9.826   1.00 12.64 ? 506  HIS A CA  1 
ATOM   2254 C  C   . HIS A 1 284 ? -16.677 -59.692 10.431  1.00 13.10 ? 506  HIS A C   1 
ATOM   2255 O  O   . HIS A 1 284 ? -17.087 -58.616 10.000  1.00 13.42 ? 506  HIS A O   1 
ATOM   2256 C  CB  . HIS A 1 284 ? -14.191 -59.917 10.544  1.00 13.20 ? 506  HIS A CB  1 
ATOM   2257 C  CG  . HIS A 1 284 ? -12.970 -60.645 10.087  1.00 12.96 ? 506  HIS A CG  1 
ATOM   2258 N  ND1 . HIS A 1 284 ? -12.363 -61.625 10.838  1.00 17.62 ? 506  HIS A ND1 1 
ATOM   2259 C  CD2 . HIS A 1 284 ? -12.269 -60.566 8.929   1.00 14.41 ? 506  HIS A CD2 1 
ATOM   2260 C  CE1 . HIS A 1 284 ? -11.329 -62.111 10.170  1.00 19.67 ? 506  HIS A CE1 1 
ATOM   2261 N  NE2 . HIS A 1 284 ? -11.245 -61.478 9.012   1.00 18.51 ? 506  HIS A NE2 1 
ATOM   2262 N  N   . ARG A 1 285 ? -17.238 -60.333 11.469  1.00 13.21 ? 507  ARG A N   1 
ATOM   2263 C  CA  A ARG A 1 285 ? -18.443 -59.823 12.120  0.50 14.13 ? 507  ARG A CA  1 
ATOM   2264 C  CA  B ARG A 1 285 ? -18.450 -59.817 12.093  0.50 14.10 ? 507  ARG A CA  1 
ATOM   2265 C  C   . ARG A 1 285 ? -18.278 -58.395 12.606  1.00 13.98 ? 507  ARG A C   1 
ATOM   2266 O  O   . ARG A 1 285 ? -19.243 -57.627 12.608  1.00 14.80 ? 507  ARG A O   1 
ATOM   2267 C  CB  A ARG A 1 285 ? -18.827 -60.718 13.303  0.50 16.25 ? 507  ARG A CB  1 
ATOM   2268 C  CB  B ARG A 1 285 ? -18.888 -60.750 13.226  0.50 16.38 ? 507  ARG A CB  1 
ATOM   2269 C  CG  A ARG A 1 285 ? -19.597 -61.976 12.930  0.50 18.34 ? 507  ARG A CG  1 
ATOM   2270 C  CG  B ARG A 1 285 ? -19.351 -62.123 12.730  0.50 17.00 ? 507  ARG A CG  1 
ATOM   2271 C  CD  A ARG A 1 285 ? -19.694 -62.903 14.146  0.50 23.95 ? 507  ARG A CD  1 
ATOM   2272 C  CD  B ARG A 1 285 ? -19.585 -63.086 13.895  0.50 24.33 ? 507  ARG A CD  1 
ATOM   2273 N  NE  A ARG A 1 285 ? -20.589 -64.033 13.933  0.50 21.78 ? 507  ARG A NE  1 
ATOM   2274 N  NE  B ARG A 1 285 ? -20.649 -62.617 14.773  0.50 21.61 ? 507  ARG A NE  1 
ATOM   2275 C  CZ  A ARG A 1 285 ? -21.705 -64.247 14.619  0.50 20.87 ? 507  ARG A CZ  1 
ATOM   2276 C  CZ  B ARG A 1 285 ? -21.729 -63.319 15.094  0.50 25.43 ? 507  ARG A CZ  1 
ATOM   2277 N  NH1 A ARG A 1 285 ? -22.097 -63.426 15.579  0.50 23.71 ? 507  ARG A NH1 1 
ATOM   2278 N  NH1 B ARG A 1 285 ? -21.901 -64.560 14.670  0.50 18.87 ? 507  ARG A NH1 1 
ATOM   2279 N  NH2 A ARG A 1 285 ? -22.446 -65.313 14.334  0.50 21.22 ? 507  ARG A NH2 1 
ATOM   2280 N  NH2 B ARG A 1 285 ? -22.655 -62.763 15.867  0.50 21.97 ? 507  ARG A NH2 1 
ATOM   2281 N  N   . ASN A 1 286 ? -17.079 -58.019 13.051  1.00 14.33 ? 508  ASN A N   1 
ATOM   2282 C  CA  A ASN A 1 286 ? -16.851 -56.657 13.518  0.54 12.35 ? 508  ASN A CA  1 
ATOM   2283 C  CA  B ASN A 1 286 ? -16.906 -56.651 13.517  0.46 12.37 ? 508  ASN A CA  1 
ATOM   2284 C  C   . ASN A 1 286 ? -16.752 -55.654 12.378  1.00 13.58 ? 508  ASN A C   1 
ATOM   2285 O  O   . ASN A 1 286 ? -16.631 -54.458 12.642  1.00 15.95 ? 508  ASN A O   1 
ATOM   2286 C  CB  A ASN A 1 286 ? -15.586 -56.590 14.379  0.54 13.88 ? 508  ASN A CB  1 
ATOM   2287 C  CB  B ASN A 1 286 ? -15.723 -56.569 14.476  0.46 14.07 ? 508  ASN A CB  1 
ATOM   2288 C  CG  A ASN A 1 286 ? -15.412 -55.238 15.054  0.54 20.40 ? 508  ASN A CG  1 
ATOM   2289 C  CG  B ASN A 1 286 ? -16.083 -57.061 15.862  0.46 27.76 ? 508  ASN A CG  1 
ATOM   2290 O  OD1 A ASN A 1 286 ? -14.469 -54.506 14.760  0.54 24.35 ? 508  ASN A OD1 1 
ATOM   2291 O  OD1 B ASN A 1 286 ? -17.255 -57.044 16.246  0.46 24.65 ? 508  ASN A OD1 1 
ATOM   2292 N  ND2 A ASN A 1 286 ? -16.333 -54.894 15.946  0.54 23.89 ? 508  ASN A ND2 1 
ATOM   2293 N  ND2 B ASN A 1 286 ? -15.087 -57.507 16.617  0.46 25.12 ? 508  ASN A ND2 1 
ATOM   2294 N  N   . GLY A 1 287 ? -16.777 -56.111 11.130  1.00 12.66 ? 509  GLY A N   1 
ATOM   2295 C  CA  . GLY A 1 287 ? -16.914 -55.214 9.993   1.00 11.98 ? 509  GLY A CA  1 
ATOM   2296 C  C   . GLY A 1 287 ? -15.635 -54.821 9.280   1.00 12.61 ? 509  GLY A C   1 
ATOM   2297 O  O   . GLY A 1 287 ? -15.325 -53.631 9.172   1.00 14.04 ? 509  GLY A O   1 
ATOM   2298 N  N   . PHE A 1 288 ? -14.895 -55.802 8.777   1.00 11.50 ? 510  PHE A N   1 
ATOM   2299 C  CA  . PHE A 1 288 ? -13.713 -55.513 7.971   1.00 12.80 ? 510  PHE A CA  1 
ATOM   2300 C  C   . PHE A 1 288 ? -13.351 -56.773 7.210   1.00 11.13 ? 510  PHE A C   1 
ATOM   2301 O  O   . PHE A 1 288 ? -13.785 -57.874 7.570   1.00 11.17 ? 510  PHE A O   1 
ATOM   2302 C  CB  . PHE A 1 288 ? -12.534 -55.033 8.827   1.00 11.81 ? 510  PHE A CB  1 
ATOM   2303 C  CG  . PHE A 1 288 ? -12.055 -56.048 9.840   1.00 12.08 ? 510  PHE A CG  1 
ATOM   2304 C  CD1 . PHE A 1 288 ? -12.683 -56.170 11.076  1.00 13.73 ? 510  PHE A CD1 1 
ATOM   2305 C  CD2 . PHE A 1 288 ? -10.959 -56.851 9.572   1.00 14.78 ? 510  PHE A CD2 1 
ATOM   2306 C  CE1 . PHE A 1 288 ? -12.238 -57.093 12.021  1.00 15.89 ? 510  PHE A CE1 1 
ATOM   2307 C  CE2 . PHE A 1 288 ? -10.505 -57.780 10.519  1.00 14.34 ? 510  PHE A CE2 1 
ATOM   2308 C  CZ  . PHE A 1 288 ? -11.147 -57.898 11.735  1.00 13.10 ? 510  PHE A CZ  1 
ATOM   2309 N  N   . PHE A 1 289 ? -12.542 -56.599 6.159   1.00 12.47 ? 511  PHE A N   1 
ATOM   2310 C  CA  . PHE A 1 289 ? -12.131 -57.688 5.278   1.00 12.04 ? 511  PHE A CA  1 
ATOM   2311 C  C   . PHE A 1 289 ? -10.693 -58.100 5.553   1.00 11.52 ? 511  PHE A C   1 
ATOM   2312 O  O   . PHE A 1 289 ? -9.831  -57.249 5.782   1.00 10.81 ? 511  PHE A O   1 
ATOM   2313 C  CB  . PHE A 1 289 ? -12.199 -57.277 3.802   1.00 9.25  ? 511  PHE A CB  1 
ATOM   2314 C  CG  . PHE A 1 289 ? -13.582 -56.984 3.293   1.00 10.42 ? 511  PHE A CG  1 
ATOM   2315 C  CD1 . PHE A 1 289 ? -14.197 -55.771 3.561   1.00 13.56 ? 511  PHE A CD1 1 
ATOM   2316 C  CD2 . PHE A 1 289 ? -14.234 -57.896 2.495   1.00 12.07 ? 511  PHE A CD2 1 
ATOM   2317 C  CE1 . PHE A 1 289 ? -15.462 -55.489 3.054   1.00 13.02 ? 511  PHE A CE1 1 
ATOM   2318 C  CE2 . PHE A 1 289 ? -15.501 -57.631 1.986   1.00 14.77 ? 511  PHE A CE2 1 
ATOM   2319 C  CZ  . PHE A 1 289 ? -16.116 -56.426 2.265   1.00 15.84 ? 511  PHE A CZ  1 
ATOM   2320 N  N   . THR A 1 290 ? -10.425 -59.400 5.476   1.00 11.83 ? 512  THR A N   1 
ATOM   2321 C  CA  . THR A 1 290 ? -9.049  -59.871 5.399   1.00 12.46 ? 512  THR A CA  1 
ATOM   2322 C  C   . THR A 1 290 ? -8.902  -60.824 4.224   1.00 13.17 ? 512  THR A C   1 
ATOM   2323 O  O   . THR A 1 290 ? -9.863  -61.454 3.778   1.00 14.59 ? 512  THR A O   1 
ATOM   2324 C  CB  . THR A 1 290 ? -8.570  -60.577 6.682   1.00 12.85 ? 512  THR A CB  1 
ATOM   2325 O  OG1 . THR A 1 290 ? -9.359  -61.747 6.920   1.00 14.13 ? 512  THR A OG1 1 
ATOM   2326 C  CG2 . THR A 1 290 ? -8.656  -59.642 7.888   1.00 13.47 ? 512  THR A CG2 1 
ATOM   2327 N  N   . VAL A 1 291 ? -7.673  -60.922 3.722   1.00 12.51 ? 513  VAL A N   1 
ATOM   2328 C  CA  . VAL A 1 291 ? -7.356  -61.829 2.632   1.00 14.09 ? 513  VAL A CA  1 
ATOM   2329 C  C   . VAL A 1 291 ? -6.045  -62.521 2.962   1.00 15.14 ? 513  VAL A C   1 
ATOM   2330 O  O   . VAL A 1 291 ? -5.255  -62.040 3.775   1.00 14.62 ? 513  VAL A O   1 
ATOM   2331 C  CB  . VAL A 1 291 ? -7.229  -61.098 1.284   1.00 12.84 ? 513  VAL A CB  1 
ATOM   2332 C  CG1 . VAL A 1 291 ? -8.557  -60.464 0.887   1.00 14.31 ? 513  VAL A CG1 1 
ATOM   2333 C  CG2 . VAL A 1 291 ? -6.149  -60.052 1.394   1.00 14.70 ? 513  VAL A CG2 1 
ATOM   2334 N  N   . SER A 1 292 ? -5.807  -63.637 2.275   1.00 15.76 ? 514  SER A N   1 
ATOM   2335 C  CA  . SER A 1 292 ? -4.569  -64.401 2.406   1.00 17.61 ? 514  SER A CA  1 
ATOM   2336 C  C   . SER A 1 292 ? -3.547  -63.852 1.415   1.00 16.19 ? 514  SER A C   1 
ATOM   2337 O  O   . SER A 1 292 ? -3.671  -64.065 0.205   1.00 19.02 ? 514  SER A O   1 
ATOM   2338 C  CB  . SER A 1 292 ? -4.830  -65.887 2.158   1.00 18.72 ? 514  SER A CB  1 
ATOM   2339 O  OG  . SER A 1 292 ? -3.605  -66.603 2.097   1.00 20.96 ? 514  SER A OG  1 
ATOM   2340 N  N   . ALA A 1 293 ? -2.538  -63.143 1.923   1.00 17.41 ? 515  ALA A N   1 
ATOM   2341 C  CA  . ALA A 1 293 ? -1.537  -62.525 1.070   1.00 18.78 ? 515  ALA A CA  1 
ATOM   2342 C  C   . ALA A 1 293 ? -0.249  -62.334 1.857   1.00 18.74 ? 515  ALA A C   1 
ATOM   2343 O  O   . ALA A 1 293 ? -0.251  -62.267 3.087   1.00 22.90 ? 515  ALA A O   1 
ATOM   2344 C  CB  . ALA A 1 293 ? -2.013  -61.176 0.515   1.00 18.13 ? 515  ALA A CB  1 
ATOM   2345 N  N   . THR A 1 294 ? 0.863   -62.229 1.126   1.00 23.98 ? 516  THR A N   1 
ATOM   2346 C  CA  . THR A 1 294 ? 2.153   -61.954 1.745   1.00 25.56 ? 516  THR A CA  1 
ATOM   2347 C  C   . THR A 1 294 ? 2.785   -60.650 1.292   1.00 26.33 ? 516  THR A C   1 
ATOM   2348 O  O   . THR A 1 294 ? 3.581   -60.078 2.043   1.00 30.49 ? 516  THR A O   1 
ATOM   2349 C  CB  . THR A 1 294 ? 3.148   -63.092 1.466   1.00 32.65 ? 516  THR A CB  1 
ATOM   2350 O  OG1 . THR A 1 294 ? 3.297   -63.267 0.051   1.00 32.61 ? 516  THR A OG1 1 
ATOM   2351 C  CG2 . THR A 1 294 ? 2.661   -64.390 2.087   1.00 31.65 ? 516  THR A CG2 1 
ATOM   2352 N  N   . ALA A 1 295 ? 2.451   -60.158 0.110   1.00 22.36 ? 517  ALA A N   1 
ATOM   2353 C  CA  . ALA A 1 295 ? 3.097   -58.977 -0.435  1.00 23.51 ? 517  ALA A CA  1 
ATOM   2354 C  C   . ALA A 1 295 ? 2.047   -57.937 -0.786  1.00 20.20 ? 517  ALA A C   1 
ATOM   2355 O  O   . ALA A 1 295 ? 0.865   -58.250 -0.944  1.00 19.85 ? 517  ALA A O   1 
ATOM   2356 C  CB  . ALA A 1 295 ? 3.924   -59.313 -1.681  1.00 28.67 ? 517  ALA A CB  1 
ATOM   2357 N  N   . ARG A 1 296 ? 2.511   -56.698 -0.921  1.00 15.03 ? 518  ARG A N   1 
ATOM   2358 C  CA  . ARG A 1 296 ? 1.647   -55.595 -1.327  1.00 17.65 ? 518  ARG A CA  1 
ATOM   2359 C  C   . ARG A 1 296 ? 0.894   -55.947 -2.600  1.00 21.54 ? 518  ARG A C   1 
ATOM   2360 O  O   . ARG A 1 296 ? 1.490   -56.359 -3.600  1.00 16.51 ? 518  ARG A O   1 
ATOM   2361 C  CB  . ARG A 1 296 ? 2.469   -54.323 -1.538  1.00 16.67 ? 518  ARG A CB  1 
ATOM   2362 C  CG  . ARG A 1 296 ? 1.639   -53.145 -2.027  1.00 17.07 ? 518  ARG A CG  1 
ATOM   2363 C  CD  . ARG A 1 296 ? 2.492   -51.891 -2.244  1.00 18.25 ? 518  ARG A CD  1 
ATOM   2364 N  NE  . ARG A 1 296 ? 3.366   -52.022 -3.405  1.00 28.03 ? 518  ARG A NE  1 
ATOM   2365 C  CZ  . ARG A 1 296 ? 4.663   -52.289 -3.352  1.00 34.94 ? 518  ARG A CZ  1 
ATOM   2366 N  NH1 . ARG A 1 296 ? 5.299   -52.408 -2.196  1.00 23.54 ? 518  ARG A NH1 1 
ATOM   2367 N  NH2 . ARG A 1 296 ? 5.341   -52.439 -4.489  1.00 30.29 ? 518  ARG A NH2 1 
ATOM   2368 N  N   . THR A 1 297 ? -0.425  -55.794 -2.553  1.00 16.31 ? 519  THR A N   1 
ATOM   2369 C  CA  . THR A 1 297 ? -1.280  -56.126 -3.680  1.00 12.45 ? 519  THR A CA  1 
ATOM   2370 C  C   . THR A 1 297 ? -2.322  -55.030 -3.826  1.00 17.21 ? 519  THR A C   1 
ATOM   2371 O  O   . THR A 1 297 ? -3.007  -54.694 -2.855  1.00 15.96 ? 519  THR A O   1 
ATOM   2372 C  CB  . THR A 1 297 ? -1.959  -57.482 -3.474  1.00 13.68 ? 519  THR A CB  1 
ATOM   2373 O  OG1 . THR A 1 297 ? -0.974  -58.478 -3.139  1.00 19.45 ? 519  THR A OG1 1 
ATOM   2374 C  CG2 . THR A 1 297 ? -2.687  -57.903 -4.740  1.00 16.41 ? 519  THR A CG2 1 
ATOM   2375 N  N   . LEU A 1 298 ? -2.418  -54.460 -5.023  1.00 13.89 ? 520  LEU A N   1 
ATOM   2376 C  CA  . LEU A 1 298 ? -3.346  -53.374 -5.316  1.00 12.36 ? 520  LEU A CA  1 
ATOM   2377 C  C   . LEU A 1 298 ? -4.469  -53.909 -6.194  1.00 16.35 ? 520  LEU A C   1 
ATOM   2378 O  O   . LEU A 1 298 ? -4.209  -54.528 -7.233  1.00 17.66 ? 520  LEU A O   1 
ATOM   2379 C  CB  . LEU A 1 298 ? -2.634  -52.216 -6.028  1.00 13.41 ? 520  LEU A CB  1 
ATOM   2380 C  CG  . LEU A 1 298 ? -1.412  -51.631 -5.323  1.00 20.05 ? 520  LEU A CG  1 
ATOM   2381 C  CD1 . LEU A 1 298 ? -0.744  -50.586 -6.196  1.00 17.82 ? 520  LEU A CD1 1 
ATOM   2382 C  CD2 . LEU A 1 298 ? -1.813  -51.003 -4.004  1.00 18.10 ? 520  LEU A CD2 1 
ATOM   2383 N  N   . ILE A 1 299 ? -5.712  -53.649 -5.795  1.00 12.74 ? 521  ILE A N   1 
ATOM   2384 C  CA  . ILE A 1 299 ? -6.892  -54.176 -6.477  1.00 12.75 ? 521  ILE A CA  1 
ATOM   2385 C  C   . ILE A 1 299 ? -7.654  -53.011 -7.100  1.00 14.65 ? 521  ILE A C   1 
ATOM   2386 O  O   . ILE A 1 299 ? -8.104  -52.100 -6.391  1.00 14.23 ? 521  ILE A O   1 
ATOM   2387 C  CB  . ILE A 1 299 ? -7.796  -54.962 -5.511  1.00 14.79 ? 521  ILE A CB  1 
ATOM   2388 C  CG1 . ILE A 1 299 ? -6.994  -56.034 -4.765  1.00 19.07 ? 521  ILE A CG1 1 
ATOM   2389 C  CG2 . ILE A 1 299 ? -8.968  -55.588 -6.266  1.00 16.66 ? 521  ILE A CG2 1 
ATOM   2390 C  CD1 . ILE A 1 299 ? -6.397  -57.106 -5.675  1.00 22.29 ? 521  ILE A CD1 1 
ATOM   2391 N  N   . VAL A 1 300 ? -7.805  -53.036 -8.423  1.00 13.37 ? 522  VAL A N   1 
ATOM   2392 C  CA  . VAL A 1 300 ? -8.595  -52.015 -9.104  1.00 10.88 ? 522  VAL A CA  1 
ATOM   2393 C  C   . VAL A 1 300 ? -10.068 -52.273 -8.805  1.00 17.77 ? 522  VAL A C   1 
ATOM   2394 O  O   . VAL A 1 300 ? -10.476 -53.435 -8.639  1.00 16.28 ? 522  VAL A O   1 
ATOM   2395 C  CB  . VAL A 1 300 ? -8.306  -51.995 -10.615 1.00 19.72 ? 522  VAL A CB  1 
ATOM   2396 C  CG1 . VAL A 1 300 ? -6.886  -51.505 -10.856 1.00 22.29 ? 522  VAL A CG1 1 
ATOM   2397 C  CG2 . VAL A 1 300 ? -8.515  -53.365 -11.214 1.00 30.11 ? 522  VAL A CG2 1 
ATOM   2398 N  N   . PRO A 1 301 ? -10.897 -51.229 -8.730  1.00 13.68 ? 523  PRO A N   1 
ATOM   2399 C  CA  . PRO A 1 301 ? -12.234 -51.379 -8.144  1.00 17.26 ? 523  PRO A CA  1 
ATOM   2400 C  C   . PRO A 1 301 ? -13.318 -51.783 -9.128  1.00 19.06 ? 523  PRO A C   1 
ATOM   2401 O  O   . PRO A 1 301 ? -14.499 -51.529 -8.873  1.00 17.02 ? 523  PRO A O   1 
ATOM   2402 C  CB  . PRO A 1 301 ? -12.511 -49.982 -7.578  1.00 16.71 ? 523  PRO A CB  1 
ATOM   2403 C  CG  . PRO A 1 301 ? -11.799 -49.066 -8.531  1.00 17.07 ? 523  PRO A CG  1 
ATOM   2404 C  CD  . PRO A 1 301 ? -10.551 -49.816 -8.973  1.00 18.69 ? 523  PRO A CD  1 
ATOM   2405 N  N   . ASP A 1 302 ? -12.953 -52.423 -10.234 1.00 15.64 ? 524  ASP A N   1 
ATOM   2406 C  CA  . ASP A 1 302 ? -13.965 -52.781 -11.227 1.00 19.09 ? 524  ASP A CA  1 
ATOM   2407 C  C   . ASP A 1 302 ? -14.502 -54.189 -10.988 1.00 21.73 ? 524  ASP A C   1 
ATOM   2408 O  O   . ASP A 1 302 ? -14.585 -55.027 -11.886 1.00 22.46 ? 524  ASP A O   1 
ATOM   2409 C  CB  . ASP A 1 302 ? -13.405 -52.614 -12.636 1.00 26.92 ? 524  ASP A CB  1 
ATOM   2410 C  CG  . ASP A 1 302 ? -12.171 -53.457 -12.895 1.00 38.65 ? 524  ASP A CG  1 
ATOM   2411 O  OD1 . ASP A 1 302 ? -11.739 -54.199 -11.993 1.00 35.23 ? 524  ASP A OD1 1 
ATOM   2412 O  OD2 . ASP A 1 302 ? -11.637 -53.379 -14.026 1.00 52.58 ? 524  ASP A OD2 1 
ATOM   2413 N  N   . GLY A 1 303 ? -14.883 -54.441 -9.739  1.00 16.05 ? 525  GLY A N   1 
ATOM   2414 C  CA  . GLY A 1 303 ? -15.488 -55.693 -9.336  1.00 14.53 ? 525  GLY A CA  1 
ATOM   2415 C  C   . GLY A 1 303 ? -16.399 -55.442 -8.153  1.00 17.78 ? 525  GLY A C   1 
ATOM   2416 O  O   . GLY A 1 303 ? -16.461 -54.329 -7.631  1.00 14.95 ? 525  GLY A O   1 
ATOM   2417 N  N   . TYR A 1 304 ? -17.126 -56.478 -7.737  1.00 15.28 ? 526  TYR A N   1 
ATOM   2418 C  CA  . TYR A 1 304 ? -17.984 -56.365 -6.566  1.00 14.96 ? 526  TYR A CA  1 
ATOM   2419 C  C   . TYR A 1 304 ? -17.781 -57.567 -5.653  1.00 15.93 ? 526  TYR A C   1 
ATOM   2420 O  O   . TYR A 1 304 ? -17.345 -58.637 -6.083  1.00 16.83 ? 526  TYR A O   1 
ATOM   2421 C  CB  . TYR A 1 304 ? -19.469 -56.227 -6.954  1.00 21.28 ? 526  TYR A CB  1 
ATOM   2422 C  CG  . TYR A 1 304 ? -20.027 -57.418 -7.696  1.00 18.41 ? 526  TYR A CG  1 
ATOM   2423 C  CD1 . TYR A 1 304 ? -19.889 -57.522 -9.077  1.00 22.20 ? 526  TYR A CD1 1 
ATOM   2424 C  CD2 . TYR A 1 304 ? -20.690 -58.437 -7.018  1.00 22.50 ? 526  TYR A CD2 1 
ATOM   2425 C  CE1 . TYR A 1 304 ? -20.396 -58.615 -9.765  1.00 33.85 ? 526  TYR A CE1 1 
ATOM   2426 C  CE2 . TYR A 1 304 ? -21.205 -59.537 -7.703  1.00 25.39 ? 526  TYR A CE2 1 
ATOM   2427 C  CZ  . TYR A 1 304 ? -21.052 -59.616 -9.073  1.00 33.56 ? 526  TYR A CZ  1 
ATOM   2428 O  OH  . TYR A 1 304 ? -21.557 -60.700 -9.759  1.00 32.31 ? 526  TYR A OH  1 
ATOM   2429 N  N   . PHE A 1 305 ? -18.091 -57.375 -4.374  1.00 15.21 ? 527  PHE A N   1 
ATOM   2430 C  CA  . PHE A 1 305 ? -18.041 -58.469 -3.418  1.00 12.58 ? 527  PHE A CA  1 
ATOM   2431 C  C   . PHE A 1 305 ? -19.388 -59.168 -3.336  1.00 15.98 ? 527  PHE A C   1 
ATOM   2432 O  O   . PHE A 1 305 ? -20.443 -58.526 -3.289  1.00 17.17 ? 527  PHE A O   1 
ATOM   2433 C  CB  . PHE A 1 305 ? -17.641 -57.973 -2.029  1.00 13.76 ? 527  PHE A CB  1 
ATOM   2434 C  CG  . PHE A 1 305 ? -16.175 -57.728 -1.881  1.00 13.14 ? 527  PHE A CG  1 
ATOM   2435 C  CD1 . PHE A 1 305 ? -15.308 -58.791 -1.702  1.00 12.85 ? 527  PHE A CD1 1 
ATOM   2436 C  CD2 . PHE A 1 305 ? -15.663 -56.439 -1.918  1.00 18.31 ? 527  PHE A CD2 1 
ATOM   2437 C  CE1 . PHE A 1 305 ? -13.961 -58.587 -1.555  1.00 16.71 ? 527  PHE A CE1 1 
ATOM   2438 C  CE2 . PHE A 1 305 ? -14.312 -56.220 -1.769  1.00 16.54 ? 527  PHE A CE2 1 
ATOM   2439 C  CZ  . PHE A 1 305 ? -13.455 -57.298 -1.587  1.00 18.24 ? 527  PHE A CZ  1 
ATOM   2440 N  N   . ARG A 1 306 ? -19.333 -60.491 -3.279  1.00 17.78 ? 528  ARG A N   1 
ATOM   2441 C  CA  . ARG A 1 306 ? -20.504 -61.351 -3.223  1.00 16.98 ? 528  ARG A CA  1 
ATOM   2442 C  C   . ARG A 1 306 ? -20.374 -62.233 -1.992  1.00 20.88 ? 528  ARG A C   1 
ATOM   2443 O  O   . ARG A 1 306 ? -19.335 -62.871 -1.800  1.00 17.28 ? 528  ARG A O   1 
ATOM   2444 C  CB  . ARG A 1 306 ? -20.585 -62.199 -4.500  1.00 20.45 ? 528  ARG A CB  1 
ATOM   2445 C  CG  . ARG A 1 306 ? -21.809 -63.073 -4.650  1.00 26.17 ? 528  ARG A CG  1 
ATOM   2446 C  CD  . ARG A 1 306 ? -21.629 -63.976 -5.863  1.00 27.24 ? 528  ARG A CD  1 
ATOM   2447 N  NE  . ARG A 1 306 ? -20.611 -64.994 -5.618  1.00 26.45 ? 528  ARG A NE  1 
ATOM   2448 C  CZ  . ARG A 1 306 ? -19.983 -65.679 -6.562  1.00 29.44 ? 528  ARG A CZ  1 
ATOM   2449 N  NH1 . ARG A 1 306 ? -20.219 -65.461 -7.847  1.00 35.07 ? 528  ARG A NH1 1 
ATOM   2450 N  NH2 . ARG A 1 306 ? -19.086 -66.598 -6.209  1.00 30.47 ? 528  ARG A NH2 1 
ATOM   2451 N  N   . PHE A 1 307 ? -21.398 -62.236 -1.143  1.00 16.52 ? 529  PHE A N   1 
ATOM   2452 C  CA  . PHE A 1 307 ? -21.407 -63.115 0.022   1.00 16.31 ? 529  PHE A CA  1 
ATOM   2453 C  C   . PHE A 1 307 ? -21.746 -64.529 -0.417  1.00 19.58 ? 529  PHE A C   1 
ATOM   2454 O  O   . PHE A 1 307 ? -22.769 -64.758 -1.069  1.00 18.69 ? 529  PHE A O   1 
ATOM   2455 C  CB  . PHE A 1 307 ? -22.418 -62.632 1.064   1.00 18.86 ? 529  PHE A CB  1 
ATOM   2456 C  CG  . PHE A 1 307 ? -22.670 -63.627 2.176   1.00 15.70 ? 529  PHE A CG  1 
ATOM   2457 C  CD1 . PHE A 1 307 ? -21.663 -63.960 3.062   1.00 15.85 ? 529  PHE A CD1 1 
ATOM   2458 C  CD2 . PHE A 1 307 ? -23.913 -64.223 2.331   1.00 20.01 ? 529  PHE A CD2 1 
ATOM   2459 C  CE1 . PHE A 1 307 ? -21.886 -64.868 4.088   1.00 16.65 ? 529  PHE A CE1 1 
ATOM   2460 C  CE2 . PHE A 1 307 ? -24.141 -65.132 3.352   1.00 23.76 ? 529  PHE A CE2 1 
ATOM   2461 C  CZ  . PHE A 1 307 ? -23.119 -65.453 4.234   1.00 21.45 ? 529  PHE A CZ  1 
ATOM   2462 N  N   . ASP A 1 308 ? -20.898 -65.485 -0.059  1.00 18.88 ? 530  ASP A N   1 
ATOM   2463 C  CA  . ASP A 1 308 ? -21.161 -66.856 -0.467  1.00 18.12 ? 530  ASP A CA  1 
ATOM   2464 C  C   . ASP A 1 308 ? -21.610 -67.766 0.671   1.00 22.41 ? 530  ASP A C   1 
ATOM   2465 O  O   . ASP A 1 308 ? -22.568 -68.525 0.490   1.00 19.13 ? 530  ASP A O   1 
ATOM   2466 C  CB  . ASP A 1 308 ? -19.933 -67.424 -1.189  1.00 21.57 ? 530  ASP A CB  1 
ATOM   2467 C  CG  . ASP A 1 308 ? -19.848 -66.934 -2.647  1.00 32.23 ? 530  ASP A CG  1 
ATOM   2468 O  OD1 . ASP A 1 308 ? -20.810 -66.284 -3.117  1.00 28.43 ? 530  ASP A OD1 1 
ATOM   2469 O  OD2 . ASP A 1 308 ? -18.833 -67.186 -3.329  1.00 30.38 ? 530  ASP A OD2 1 
ATOM   2470 N  N   . SER A 1 309 ? -21.015 -67.686 1.862   1.00 18.58 ? 531  SER A N   1 
ATOM   2471 C  CA  . SER A 1 309 ? -21.482 -68.548 2.948   1.00 18.85 ? 531  SER A CA  1 
ATOM   2472 C  C   . SER A 1 309 ? -20.853 -68.123 4.261   1.00 17.02 ? 531  SER A C   1 
ATOM   2473 O  O   . SER A 1 309 ? -19.798 -67.488 4.289   1.00 17.54 ? 531  SER A O   1 
ATOM   2474 C  CB  . SER A 1 309 ? -21.153 -70.022 2.694   1.00 27.19 ? 531  SER A CB  1 
ATOM   2475 O  OG  . SER A 1 309 ? -19.778 -70.184 2.429   1.00 30.01 ? 531  SER A OG  1 
ATOM   2476 N  N   . TRP A 1 310 ? -21.504 -68.519 5.349   1.00 16.57 ? 532  TRP A N   1 
ATOM   2477 C  CA  . TRP A 1 310 ? -20.907 -68.400 6.674   1.00 18.07 ? 532  TRP A CA  1 
ATOM   2478 C  C   . TRP A 1 310 ? -19.988 -69.593 6.899   1.00 25.16 ? 532  TRP A C   1 
ATOM   2479 O  O   . TRP A 1 310 ? -20.360 -70.729 6.589   1.00 24.38 ? 532  TRP A O   1 
ATOM   2480 C  CB  . TRP A 1 310 ? -21.991 -68.351 7.747   1.00 19.55 ? 532  TRP A CB  1 
ATOM   2481 C  CG  . TRP A 1 310 ? -22.831 -67.102 7.705   1.00 19.19 ? 532  TRP A CG  1 
ATOM   2482 C  CD1 . TRP A 1 310 ? -24.099 -66.976 7.192   1.00 18.07 ? 532  TRP A CD1 1 
ATOM   2483 C  CD2 . TRP A 1 310 ? -22.453 -65.800 8.164   1.00 17.44 ? 532  TRP A CD2 1 
ATOM   2484 N  NE1 . TRP A 1 310 ? -24.529 -65.678 7.320   1.00 18.19 ? 532  TRP A NE1 1 
ATOM   2485 C  CE2 . TRP A 1 310 ? -23.544 -64.937 7.920   1.00 17.99 ? 532  TRP A CE2 1 
ATOM   2486 C  CE3 . TRP A 1 310 ? -21.307 -65.285 8.779   1.00 14.99 ? 532  TRP A CE3 1 
ATOM   2487 C  CZ2 . TRP A 1 310 ? -23.517 -63.585 8.254   1.00 17.86 ? 532  TRP A CZ2 1 
ATOM   2488 C  CZ3 . TRP A 1 310 ? -21.280 -63.938 9.118   1.00 19.37 ? 532  TRP A CZ3 1 
ATOM   2489 C  CH2 . TRP A 1 310 ? -22.377 -63.099 8.849   1.00 15.68 ? 532  TRP A CH2 1 
ATOM   2490 N  N   . VAL A 1 311 ? -18.786 -69.346 7.421   1.00 17.10 ? 533  VAL A N   1 
ATOM   2491 C  CA  . VAL A 1 311 ? -17.806 -70.413 7.599   1.00 18.88 ? 533  VAL A CA  1 
ATOM   2492 C  C   . VAL A 1 311 ? -17.236 -70.353 9.009   1.00 22.36 ? 533  VAL A C   1 
ATOM   2493 O  O   . VAL A 1 311 ? -17.370 -69.353 9.716   1.00 16.78 ? 533  VAL A O   1 
ATOM   2494 C  CB  . VAL A 1 311 ? -16.663 -70.361 6.558   1.00 19.88 ? 533  VAL A CB  1 
ATOM   2495 C  CG1 . VAL A 1 311 ? -17.194 -70.616 5.155   1.00 17.39 ? 533  VAL A CG1 1 
ATOM   2496 C  CG2 . VAL A 1 311 ? -15.934 -69.033 6.618   1.00 16.37 ? 533  VAL A CG2 1 
ATOM   2497 N  N   . ASN A 1 312 ? -16.599 -71.455 9.410   1.00 21.26 ? 534  ASN A N   1 
ATOM   2498 C  CA  . ASN A 1 312 ? -15.971 -71.555 10.724  1.00 23.15 ? 534  ASN A CA  1 
ATOM   2499 C  C   . ASN A 1 312 ? -14.729 -70.669 10.782  1.00 16.97 ? 534  ASN A C   1 
ATOM   2500 O  O   . ASN A 1 312 ? -14.109 -70.354 9.766   1.00 17.12 ? 534  ASN A O   1 
ATOM   2501 C  CB  . ASN A 1 312 ? -15.605 -73.017 11.028  1.00 22.13 ? 534  ASN A CB  1 
ATOM   2502 C  CG  . ASN A 1 312 ? -15.089 -73.220 12.453  1.00 23.99 ? 534  ASN A CG  1 
ATOM   2503 O  OD1 . ASN A 1 312 ? -13.888 -73.220 12.686  1.00 26.82 ? 534  ASN A OD1 1 
ATOM   2504 N  ND2 . ASN A 1 312 ? -15.999 -73.387 13.401  1.00 20.31 ? 534  ASN A ND2 1 
ATOM   2505 N  N   . ARG A 1 313 ? -14.360 -70.267 12.000  1.00 15.69 ? 535  ARG A N   1 
ATOM   2506 C  CA  . ARG A 1 313 ? -13.229 -69.355 12.147  1.00 15.56 ? 535  ARG A CA  1 
ATOM   2507 C  C   . ARG A 1 313 ? -11.905 -69.970 11.704  1.00 15.94 ? 535  ARG A C   1 
ATOM   2508 O  O   . ARG A 1 313 ? -10.951 -69.226 11.442  1.00 15.67 ? 535  ARG A O   1 
ATOM   2509 C  CB  . ARG A 1 313 ? -13.134 -68.855 13.595  1.00 15.61 ? 535  ARG A CB  1 
ATOM   2510 C  CG  . ARG A 1 313 ? -12.903 -69.930 14.669  1.00 14.34 ? 535  ARG A CG  1 
ATOM   2511 C  CD  . ARG A 1 313 ? -13.032 -69.252 16.032  1.00 16.45 ? 535  ARG A CD  1 
ATOM   2512 N  NE  . ARG A 1 313 ? -12.513 -70.028 17.151  1.00 18.55 ? 535  ARG A NE  1 
ATOM   2513 C  CZ  . ARG A 1 313 ? -11.974 -69.483 18.233  1.00 19.76 ? 535  ARG A CZ  1 
ATOM   2514 N  NH1 . ARG A 1 313 ? -11.832 -68.168 18.349  1.00 17.56 ? 535  ARG A NH1 1 
ATOM   2515 N  NH2 . ARG A 1 313 ? -11.556 -70.273 19.218  1.00 16.43 ? 535  ARG A NH2 1 
ATOM   2516 N  N   . PHE A 1 314 ? -11.816 -71.295 11.601  1.00 16.49 ? 536  PHE A N   1 
ATOM   2517 C  CA  . PHE A 1 314 ? -10.583 -71.934 11.151  1.00 16.11 ? 536  PHE A CA  1 
ATOM   2518 C  C   . PHE A 1 314 ? -10.537 -72.142 9.639   1.00 14.98 ? 536  PHE A C   1 
ATOM   2519 O  O   . PHE A 1 314 ? -9.629  -72.822 9.144   1.00 18.47 ? 536  PHE A O   1 
ATOM   2520 C  CB  . PHE A 1 314 ? -10.380 -73.266 11.890  1.00 20.17 ? 536  PHE A CB  1 
ATOM   2521 C  CG  . PHE A 1 314 ? -9.807  -73.096 13.276  1.00 18.04 ? 536  PHE A CG  1 
ATOM   2522 C  CD1 . PHE A 1 314 ? -8.434  -73.003 13.459  1.00 16.49 ? 536  PHE A CD1 1 
ATOM   2523 C  CD2 . PHE A 1 314 ? -10.638 -72.989 14.385  1.00 20.40 ? 536  PHE A CD2 1 
ATOM   2524 C  CE1 . PHE A 1 314 ? -7.895  -72.823 14.728  1.00 16.40 ? 536  PHE A CE1 1 
ATOM   2525 C  CE2 . PHE A 1 314 ? -10.101 -72.809 15.667  1.00 16.99 ? 536  PHE A CE2 1 
ATOM   2526 C  CZ  . PHE A 1 314 ? -8.725  -72.729 15.830  1.00 16.58 ? 536  PHE A CZ  1 
ATOM   2527 N  N   . TYR A 1 315 ? -11.456 -71.530 8.892   1.00 16.48 ? 537  TYR A N   1 
ATOM   2528 C  CA  . TYR A 1 315 ? -11.451 -71.644 7.433   1.00 18.04 ? 537  TYR A CA  1 
ATOM   2529 C  C   . TYR A 1 315 ? -10.184 -71.035 6.850   1.00 18.41 ? 537  TYR A C   1 
ATOM   2530 O  O   . TYR A 1 315 ? -9.774  -69.943 7.246   1.00 18.63 ? 537  TYR A O   1 
ATOM   2531 C  CB  . TYR A 1 315 ? -12.682 -70.944 6.864   1.00 16.60 ? 537  TYR A CB  1 
ATOM   2532 C  CG  . TYR A 1 315 ? -12.913 -71.200 5.391   1.00 15.33 ? 537  TYR A CG  1 
ATOM   2533 C  CD1 . TYR A 1 315 ? -12.345 -70.380 4.419   1.00 21.39 ? 537  TYR A CD1 1 
ATOM   2534 C  CD2 . TYR A 1 315 ? -13.702 -72.267 4.979   1.00 24.60 ? 537  TYR A CD2 1 
ATOM   2535 C  CE1 . TYR A 1 315 ? -12.558 -70.626 3.055   1.00 19.77 ? 537  TYR A CE1 1 
ATOM   2536 C  CE2 . TYR A 1 315 ? -13.923 -72.516 3.625   1.00 27.09 ? 537  TYR A CE2 1 
ATOM   2537 C  CZ  . TYR A 1 315 ? -13.350 -71.697 2.676   1.00 29.38 ? 537  TYR A CZ  1 
ATOM   2538 O  OH  . TYR A 1 315 ? -13.578 -71.963 1.343   1.00 34.32 ? 537  TYR A OH  1 
ATOM   2539 N  N   . THR A 1 316 ? -9.555  -71.745 5.906   1.00 16.41 ? 538  THR A N   1 
ATOM   2540 C  CA  . THR A 1 316 ? -8.352  -71.270 5.241   1.00 16.35 ? 538  THR A CA  1 
ATOM   2541 C  C   . THR A 1 316 ? -8.736  -70.725 3.874   1.00 15.65 ? 538  THR A C   1 
ATOM   2542 O  O   . THR A 1 316 ? -9.278  -71.460 3.044   1.00 18.32 ? 538  THR A O   1 
ATOM   2543 C  CB  . THR A 1 316 ? -7.309  -72.381 5.079   1.00 21.68 ? 538  THR A CB  1 
ATOM   2544 O  OG1 . THR A 1 316 ? -6.854  -72.805 6.371   1.00 24.03 ? 538  THR A OG1 1 
ATOM   2545 C  CG2 . THR A 1 316 ? -6.124  -71.878 4.281   1.00 25.80 ? 538  THR A CG2 1 
ATOM   2546 N  N   . LEU A 1 317 ? -8.457  -69.445 3.653   1.00 16.79 ? 539  LEU A N   1 
ATOM   2547 C  CA  . LEU A 1 317 ? -8.741  -68.815 2.372   1.00 15.86 ? 539  LEU A CA  1 
ATOM   2548 C  C   . LEU A 1 317 ? -7.779  -69.293 1.293   1.00 20.05 ? 539  LEU A C   1 
ATOM   2549 O  O   . LEU A 1 317 ? -6.609  -69.581 1.552   1.00 22.15 ? 539  LEU A O   1 
ATOM   2550 C  CB  . LEU A 1 317 ? -8.616  -67.292 2.484   1.00 16.15 ? 539  LEU A CB  1 
ATOM   2551 C  CG  . LEU A 1 317 ? -9.619  -66.557 3.361   1.00 18.40 ? 539  LEU A CG  1 
ATOM   2552 C  CD1 . LEU A 1 317 ? -9.151  -65.125 3.590   1.00 16.11 ? 539  LEU A CD1 1 
ATOM   2553 C  CD2 . LEU A 1 317 ? -10.999 -66.574 2.708   1.00 15.12 ? 539  LEU A CD2 1 
ATOM   2554 N  N   . SER A 1 318 ? -8.270  -69.338 0.063   1.00 20.59 ? 540  SER A N   1 
ATOM   2555 C  CA  A SER A 1 318 ? -7.375  -69.514 -1.070  0.77 18.07 ? 540  SER A CA  1 
ATOM   2556 C  CA  B SER A 1 318 ? -7.377  -69.512 -1.073  0.23 18.33 ? 540  SER A CA  1 
ATOM   2557 C  C   . SER A 1 318 ? -6.458  -68.300 -1.163  1.00 18.49 ? 540  SER A C   1 
ATOM   2558 O  O   . SER A 1 318 ? -6.938  -67.157 -1.066  1.00 19.57 ? 540  SER A O   1 
ATOM   2559 C  CB  A SER A 1 318 ? -8.173  -69.690 -2.365  0.77 23.95 ? 540  SER A CB  1 
ATOM   2560 C  CB  B SER A 1 318 ? -8.165  -69.671 -2.374  0.23 23.94 ? 540  SER A CB  1 
ATOM   2561 O  OG  A SER A 1 318 ? -7.317  -69.818 -3.482  0.77 23.71 ? 540  SER A OG  1 
ATOM   2562 O  OG  B SER A 1 318 ? -9.008  -70.805 -2.331  0.23 20.85 ? 540  SER A OG  1 
ATOM   2563 N  N   . PRO A 1 319 ? -5.150  -68.488 -1.309  1.00 21.28 ? 541  PRO A N   1 
ATOM   2564 C  CA  . PRO A 1 319 ? -4.249  -67.338 -1.412  1.00 19.60 ? 541  PRO A CA  1 
ATOM   2565 C  C   . PRO A 1 319 ? -4.670  -66.404 -2.537  1.00 28.45 ? 541  PRO A C   1 
ATOM   2566 O  O   . PRO A 1 319 ? -5.150  -66.836 -3.587  1.00 24.31 ? 541  PRO A O   1 
ATOM   2567 C  CB  . PRO A 1 319 ? -2.887  -67.980 -1.690  1.00 24.24 ? 541  PRO A CB  1 
ATOM   2568 C  CG  . PRO A 1 319 ? -2.972  -69.299 -1.013  1.00 21.88 ? 541  PRO A CG  1 
ATOM   2569 C  CD  . PRO A 1 319 ? -4.407  -69.761 -1.201  1.00 23.78 ? 541  PRO A CD  1 
ATOM   2570 N  N   . MET A 1 320 ? -4.502  -65.111 -2.297  1.00 18.87 ? 542  MET A N   1 
ATOM   2571 C  CA  A MET A 1 320 ? -4.881  -64.124 -3.302  0.87 27.66 ? 542  MET A CA  1 
ATOM   2572 C  CA  B MET A 1 320 ? -4.840  -64.086 -3.270  0.13 27.70 ? 542  MET A CA  1 
ATOM   2573 C  C   . MET A 1 320 ? -4.011  -64.269 -4.534  1.00 37.62 ? 542  MET A C   1 
ATOM   2574 O  O   . MET A 1 320 ? -4.502  -64.111 -5.653  1.00 37.48 ? 542  MET A O   1 
ATOM   2575 C  CB  A MET A 1 320 ? -4.780  -62.704 -2.748  0.87 29.59 ? 542  MET A CB  1 
ATOM   2576 C  CB  B MET A 1 320 ? -4.617  -62.697 -2.665  0.13 29.12 ? 542  MET A CB  1 
ATOM   2577 C  CG  A MET A 1 320 ? -6.098  -62.185 -2.195  0.87 28.60 ? 542  MET A CG  1 
ATOM   2578 C  CG  B MET A 1 320 ? -4.740  -61.550 -3.643  0.13 29.86 ? 542  MET A CG  1 
ATOM   2579 S  SD  A MET A 1 320 ? -6.313  -60.446 -2.554  0.87 37.25 ? 542  MET A SD  1 
ATOM   2580 S  SD  B MET A 1 320 ? -4.927  -59.957 -2.821  0.13 25.17 ? 542  MET A SD  1 
ATOM   2581 C  CE  A MET A 1 320 ? -4.650  -59.890 -2.266  0.87 24.28 ? 542  MET A CE  1 
ATOM   2582 C  CE  B MET A 1 320 ? -6.626  -60.054 -2.272  0.13 29.82 ? 542  MET A CE  1 
ATOM   2583 O  OXT A MET A 1 320 ? -2.820  -64.572 -4.424  0.87 34.00 ? 542  MET A OXT 1 
ATOM   2584 O  OXT B MET A 1 320 ? -2.825  -64.593 -4.466  0.13 33.92 ? 542  MET A OXT 1 
HETATM 2585 CL CL  . CL  B 2 .   ? -24.201 -60.697 -1.590  1.00 28.06 ? 601  CL  A CL  1 
HETATM 2586 O  O   . HOH C 3 .   ? -18.406 -56.343 18.000  1.00 48.71 ? 701  HOH A O   1 
HETATM 2587 O  O   . HOH C 3 .   ? -23.928 -41.445 0.000   0.50 26.58 ? 702  HOH A O   1 
HETATM 2588 O  O   . HOH C 3 .   ? 7.552   -29.396 9.848   1.00 61.06 ? 703  HOH A O   1 
HETATM 2589 O  O   . HOH C 3 .   ? -11.627 -56.312 -11.174 1.00 45.99 ? 704  HOH A O   1 
HETATM 2590 O  O   . HOH C 3 .   ? -15.425 -10.361 8.796   1.00 44.74 ? 705  HOH A O   1 
HETATM 2591 O  O   . HOH C 3 .   ? -8.757  -61.469 -14.029 1.00 51.04 ? 706  HOH A O   1 
HETATM 2592 O  O   . HOH C 3 .   ? -6.448  -19.086 3.996   1.00 53.37 ? 707  HOH A O   1 
HETATM 2593 O  O   . HOH C 3 .   ? -24.971 -30.994 22.592  1.00 20.32 ? 708  HOH A O   1 
HETATM 2594 O  O   . HOH C 3 .   ? -31.367 -33.246 24.410  1.00 47.60 ? 709  HOH A O   1 
HETATM 2595 O  O   . HOH C 3 .   ? -32.131 -45.143 11.586  1.00 37.04 ? 710  HOH A O   1 
HETATM 2596 O  O   . HOH C 3 .   ? -17.654 -51.013 19.628  1.00 36.85 ? 711  HOH A O   1 
HETATM 2597 O  O   . HOH C 3 .   ? 3.675   -27.794 2.664   1.00 48.30 ? 712  HOH A O   1 
HETATM 2598 O  O   . HOH C 3 .   ? -11.877 -71.583 -0.329  1.00 32.54 ? 713  HOH A O   1 
HETATM 2599 O  O   . HOH C 3 .   ? 0.955   -27.575 7.026   1.00 47.66 ? 714  HOH A O   1 
HETATM 2600 O  O   . HOH C 3 .   ? -15.533 -23.717 31.470  1.00 55.74 ? 715  HOH A O   1 
HETATM 2601 O  O   . HOH C 3 .   ? -24.782 -38.772 0.441   1.00 39.08 ? 716  HOH A O   1 
HETATM 2602 O  O   . HOH C 3 .   ? -25.526 -33.642 27.730  1.00 36.26 ? 717  HOH A O   1 
HETATM 2603 O  O   A HOH C 3 .   ? -21.306 -60.954 -12.167 0.73 33.20 ? 718  HOH A O   1 
HETATM 2604 O  O   . HOH C 3 .   ? -7.315  -27.021 16.689  1.00 23.51 ? 719  HOH A O   1 
HETATM 2605 O  O   . HOH C 3 .   ? -21.812 -50.123 19.418  1.00 41.60 ? 720  HOH A O   1 
HETATM 2606 O  O   A HOH C 3 .   ? -23.909 -31.148 24.760  0.61 20.45 ? 721  HOH A O   1 
HETATM 2607 O  O   . HOH C 3 .   ? -34.152 -56.773 7.798   1.00 41.29 ? 722  HOH A O   1 
HETATM 2608 O  O   . HOH C 3 .   ? -24.654 -21.177 3.990   1.00 22.02 ? 723  HOH A O   1 
HETATM 2609 O  O   . HOH C 3 .   ? -2.594  -69.177 8.669   1.00 32.21 ? 724  HOH A O   1 
HETATM 2610 O  O   . HOH C 3 .   ? -28.110 -54.267 14.883  1.00 35.43 ? 725  HOH A O   1 
HETATM 2611 O  O   . HOH C 3 .   ? -4.166  -39.290 11.875  1.00 17.49 ? 726  HOH A O   1 
HETATM 2612 O  O   . HOH C 3 .   ? -14.548 -16.286 17.356  1.00 39.52 ? 727  HOH A O   1 
HETATM 2613 O  O   B HOH C 3 .   ? -19.540 -47.574 -13.070 0.77 35.57 ? 728  HOH A O   1 
HETATM 2614 O  O   . HOH C 3 .   ? -7.288  -15.417 1.717   1.00 63.55 ? 729  HOH A O   1 
HETATM 2615 O  O   . HOH C 3 .   ? -32.303 -24.355 13.136  1.00 51.26 ? 730  HOH A O   1 
HETATM 2616 O  O   . HOH C 3 .   ? -7.757  -39.792 -7.535  1.00 25.86 ? 731  HOH A O   1 
HETATM 2617 O  O   . HOH C 3 .   ? -26.037 -55.453 18.564  1.00 54.20 ? 732  HOH A O   1 
HETATM 2618 O  O   . HOH C 3 .   ? -15.714 -48.372 25.613  1.00 49.97 ? 733  HOH A O   1 
HETATM 2619 O  O   . HOH C 3 .   ? -26.026 -41.193 28.269  1.00 44.23 ? 734  HOH A O   1 
HETATM 2620 O  O   B HOH C 3 .   ? -1.467  -64.327 -2.316  0.76 37.49 ? 735  HOH A O   1 
HETATM 2621 O  O   . HOH C 3 .   ? 5.040   -60.511 4.100   1.00 44.45 ? 736  HOH A O   1 
HETATM 2622 O  O   B HOH C 3 .   ? -27.505 -31.633 9.680   0.57 21.83 ? 737  HOH A O   1 
HETATM 2623 O  O   B HOH C 3 .   ? -9.474  -72.610 0.764   0.73 38.37 ? 738  HOH A O   1 
HETATM 2624 O  O   . HOH C 3 .   ? -29.941 -51.995 1.953   1.00 36.79 ? 739  HOH A O   1 
HETATM 2625 O  O   . HOH C 3 .   ? -1.945  -31.593 8.379   1.00 17.71 ? 740  HOH A O   1 
HETATM 2626 O  O   . HOH C 3 .   ? -8.875  -46.573 -9.679  1.00 23.82 ? 741  HOH A O   1 
HETATM 2627 O  O   . HOH C 3 .   ? -1.281  -36.903 11.020  1.00 25.52 ? 742  HOH A O   1 
HETATM 2628 O  O   C HOH C 3 .   ? -12.394 -65.318 13.866  0.77 25.88 ? 743  HOH A O   1 
HETATM 2629 O  O   . HOH C 3 .   ? -23.262 -66.641 -3.804  1.00 38.60 ? 744  HOH A O   1 
HETATM 2630 O  O   A HOH C 3 .   ? -27.449 -64.299 1.439   0.83 27.81 ? 745  HOH A O   1 
HETATM 2631 O  O   . HOH C 3 .   ? -28.488 -21.558 20.164  1.00 31.14 ? 746  HOH A O   1 
HETATM 2632 O  O   . HOH C 3 .   ? -0.752  -37.092 21.186  1.00 58.46 ? 747  HOH A O   1 
HETATM 2633 O  O   . HOH C 3 .   ? -3.803  -43.495 -4.833  1.00 20.13 ? 748  HOH A O   1 
HETATM 2634 O  O   . HOH C 3 .   ? -24.432 -43.612 23.613  1.00 47.41 ? 749  HOH A O   1 
HETATM 2635 O  O   . HOH C 3 .   ? 4.984   -53.278 0.797   1.00 32.65 ? 750  HOH A O   1 
HETATM 2636 O  O   . HOH C 3 .   ? 0.772   -63.381 9.520   1.00 46.24 ? 751  HOH A O   1 
HETATM 2637 O  O   . HOH C 3 .   ? -4.309  -69.203 2.690   1.00 22.26 ? 752  HOH A O   1 
HETATM 2638 O  O   . HOH C 3 .   ? -8.628  -17.418 5.175   1.00 44.74 ? 753  HOH A O   1 
HETATM 2639 O  O   . HOH C 3 .   ? -21.202 -29.270 25.512  1.00 38.59 ? 754  HOH A O   1 
HETATM 2640 O  O   . HOH C 3 .   ? -3.503  -59.702 14.262  1.00 40.06 ? 755  HOH A O   1 
HETATM 2641 O  O   . HOH C 3 .   ? 4.130   -50.023 0.733   1.00 32.54 ? 756  HOH A O   1 
HETATM 2642 O  O   . HOH C 3 .   ? -22.170 -72.445 5.854   1.00 34.82 ? 757  HOH A O   1 
HETATM 2643 O  O   . HOH C 3 .   ? -25.582 -37.938 20.824  1.00 20.59 ? 758  HOH A O   1 
HETATM 2644 O  O   . HOH C 3 .   ? -26.254 -58.669 17.552  1.00 54.91 ? 759  HOH A O   1 
HETATM 2645 O  O   . HOH C 3 .   ? -29.952 -32.924 28.071  1.00 51.85 ? 760  HOH A O   1 
HETATM 2646 O  O   . HOH C 3 .   ? -8.319  -63.464 10.135  1.00 19.71 ? 761  HOH A O   1 
HETATM 2647 O  O   . HOH C 3 .   ? -18.936 -45.293 28.813  1.00 51.46 ? 762  HOH A O   1 
HETATM 2648 O  O   B HOH C 3 .   ? -25.091 -32.556 5.565   0.78 32.90 ? 763  HOH A O   1 
HETATM 2649 O  O   . HOH C 3 .   ? -12.526 -55.744 15.987  1.00 31.78 ? 764  HOH A O   1 
HETATM 2650 O  O   . HOH C 3 .   ? -8.624  -74.519 7.433   1.00 32.09 ? 765  HOH A O   1 
HETATM 2651 O  O   B HOH C 3 .   ? -8.163  -29.735 25.819  0.65 35.40 ? 766  HOH A O   1 
HETATM 2652 O  O   . HOH C 3 .   ? -16.038 -62.761 12.127  1.00 17.19 ? 767  HOH A O   1 
HETATM 2653 O  O   . HOH C 3 .   ? -5.319  -18.652 17.221  1.00 46.66 ? 768  HOH A O   1 
HETATM 2654 O  O   . HOH C 3 .   ? -34.407 -16.487 10.704  1.00 35.45 ? 769  HOH A O   1 
HETATM 2655 O  O   . HOH C 3 .   ? -29.069 -63.935 8.495   1.00 19.81 ? 770  HOH A O   1 
HETATM 2656 O  O   . HOH C 3 .   ? -23.129 -11.285 8.359   1.00 35.68 ? 771  HOH A O   1 
HETATM 2657 O  O   . HOH C 3 .   ? -25.131 -63.513 16.299  1.00 42.67 ? 772  HOH A O   1 
HETATM 2658 O  O   . HOH C 3 .   ? -18.944 -28.047 1.875   1.00 17.91 ? 773  HOH A O   1 
HETATM 2659 O  O   . HOH C 3 .   ? -20.600 -55.645 -2.426  1.00 25.37 ? 774  HOH A O   1 
HETATM 2660 O  O   . HOH C 3 .   ? -5.233  -42.524 -9.752  1.00 51.12 ? 775  HOH A O   1 
HETATM 2661 O  O   . HOH C 3 .   ? -29.104 -20.920 15.892  1.00 37.47 ? 776  HOH A O   1 
HETATM 2662 O  O   . HOH C 3 .   ? -8.864  -32.253 28.020  1.00 52.24 ? 777  HOH A O   1 
HETATM 2663 O  O   . HOH C 3 .   ? -3.005  -24.985 13.628  1.00 37.91 ? 778  HOH A O   1 
HETATM 2664 O  O   . HOH C 3 .   ? -11.693 -28.713 22.441  1.00 23.49 ? 779  HOH A O   1 
HETATM 2665 O  O   . HOH C 3 .   ? -17.845 -11.825 2.615   1.00 49.60 ? 780  HOH A O   1 
HETATM 2666 O  O   . HOH C 3 .   ? -27.724 -11.552 16.550  1.00 36.63 ? 781  HOH A O   1 
HETATM 2667 O  O   . HOH C 3 .   ? -35.334 -52.724 2.038   1.00 25.39 ? 782  HOH A O   1 
HETATM 2668 O  O   . HOH C 3 .   ? -34.301 -20.639 8.484   1.00 41.56 ? 783  HOH A O   1 
HETATM 2669 O  O   . HOH C 3 .   ? -26.733 -56.147 -10.826 1.00 48.10 ? 784  HOH A O   1 
HETATM 2670 O  O   . HOH C 3 .   ? -26.711 -22.016 5.643   1.00 20.21 ? 785  HOH A O   1 
HETATM 2671 O  O   . HOH C 3 .   ? -4.940  -69.111 -4.903  1.00 39.10 ? 786  HOH A O   1 
HETATM 2672 O  O   . HOH C 3 .   ? 0.738   -45.524 11.446  1.00 31.09 ? 787  HOH A O   1 
HETATM 2673 O  O   . HOH C 3 .   ? -26.245 -61.394 14.631  1.00 20.88 ? 788  HOH A O   1 
HETATM 2674 O  O   . HOH C 3 .   ? -15.987 -71.713 16.320  1.00 22.45 ? 789  HOH A O   1 
HETATM 2675 O  O   B HOH C 3 .   ? -32.819 -15.351 13.383  0.54 36.13 ? 790  HOH A O   1 
HETATM 2676 O  O   . HOH C 3 .   ? 2.907   -65.704 -0.905  1.00 52.96 ? 791  HOH A O   1 
HETATM 2677 O  O   . HOH C 3 .   ? -1.205  -61.111 -3.286  1.00 32.36 ? 792  HOH A O   1 
HETATM 2678 O  O   . HOH C 3 .   ? -16.471 -49.619 22.641  1.00 41.43 ? 793  HOH A O   1 
HETATM 2679 O  O   . HOH C 3 .   ? -19.253 -34.231 4.784   1.00 21.38 ? 794  HOH A O   1 
HETATM 2680 O  O   . HOH C 3 .   ? -23.215 -58.561 -3.910  1.00 28.89 ? 795  HOH A O   1 
HETATM 2681 O  O   . HOH C 3 .   ? -9.006  -25.862 14.873  1.00 17.63 ? 796  HOH A O   1 
HETATM 2682 O  O   . HOH C 3 .   ? -10.036 -61.315 13.199  1.00 26.02 ? 797  HOH A O   1 
HETATM 2683 O  O   . HOH C 3 .   ? -14.136 -39.880 14.998  1.00 13.85 ? 798  HOH A O   1 
HETATM 2684 O  O   . HOH C 3 .   ? -6.639  -67.872 5.253   1.00 19.50 ? 799  HOH A O   1 
HETATM 2685 O  O   . HOH C 3 .   ? -12.412 -31.331 -1.966  1.00 18.40 ? 800  HOH A O   1 
HETATM 2686 O  O   . HOH C 3 .   ? -21.303 -45.260 21.822  1.00 24.32 ? 801  HOH A O   1 
HETATM 2687 O  O   A HOH C 3 .   ? -9.418  -52.347 -15.090 0.96 51.24 ? 802  HOH A O   1 
HETATM 2688 O  O   . HOH C 3 .   ? -4.800  -24.786 19.142  1.00 34.95 ? 803  HOH A O   1 
HETATM 2689 O  O   . HOH C 3 .   ? -23.886 -56.767 17.124  1.00 35.19 ? 804  HOH A O   1 
HETATM 2690 O  O   . HOH C 3 .   ? 3.726   -42.251 11.583  1.00 50.51 ? 805  HOH A O   1 
HETATM 2691 O  O   . HOH C 3 .   ? -5.458  -54.815 -9.578  1.00 27.43 ? 806  HOH A O   1 
HETATM 2692 O  O   C HOH C 3 .   ? -29.662 -30.193 20.467  0.89 34.57 ? 807  HOH A O   1 
HETATM 2693 O  O   . HOH C 3 .   ? -18.584 -43.439 8.426   1.00 11.39 ? 808  HOH A O   1 
HETATM 2694 O  O   B HOH C 3 .   ? -16.581 -50.728 -12.136 0.99 29.67 ? 809  HOH A O   1 
HETATM 2695 O  O   . HOH C 3 .   ? -20.830 -37.236 4.178   1.00 16.28 ? 810  HOH A O   1 
HETATM 2696 O  O   . HOH C 3 .   ? -19.322 -71.037 16.198  1.00 29.83 ? 811  HOH A O   1 
HETATM 2697 O  O   . HOH C 3 .   ? -21.611 -37.431 30.788  0.50 18.69 ? 812  HOH A O   1 
HETATM 2698 O  O   A HOH C 3 .   ? -28.585 -36.913 20.294  0.93 40.06 ? 813  HOH A O   1 
HETATM 2699 O  O   . HOH C 3 .   ? -19.287 -44.983 20.324  1.00 17.48 ? 814  HOH A O   1 
HETATM 2700 O  O   . HOH C 3 .   ? -23.185 -36.175 14.290  1.00 15.28 ? 815  HOH A O   1 
HETATM 2701 O  O   . HOH C 3 .   ? -17.207 -43.876 -9.742  1.00 28.36 ? 816  HOH A O   1 
HETATM 2702 O  O   . HOH C 3 .   ? -22.922 -43.880 20.894  1.00 42.89 ? 817  HOH A O   1 
HETATM 2703 O  O   . HOH C 3 .   ? 4.085   -56.692 -4.224  1.00 21.78 ? 818  HOH A O   1 
HETATM 2704 O  O   . HOH C 3 .   ? -26.908 -56.604 8.059   1.00 18.01 ? 819  HOH A O   1 
HETATM 2705 O  O   . HOH C 3 .   ? -28.362 -36.665 27.422  1.00 48.45 ? 820  HOH A O   1 
HETATM 2706 O  O   . HOH C 3 .   ? -18.174 -15.461 28.700  1.00 64.13 ? 821  HOH A O   1 
HETATM 2707 O  O   . HOH C 3 .   ? -1.727  -45.562 1.681   1.00 25.79 ? 822  HOH A O   1 
HETATM 2708 O  O   . HOH C 3 .   ? -12.954 -39.569 9.478   1.00 14.58 ? 823  HOH A O   1 
HETATM 2709 O  O   A HOH C 3 .   ? -31.072 -23.196 10.906  0.97 30.06 ? 824  HOH A O   1 
HETATM 2710 O  O   . HOH C 3 .   ? -13.815 -45.265 -8.507  1.00 23.09 ? 825  HOH A O   1 
HETATM 2711 O  O   . HOH C 3 .   ? -16.232 -13.289 5.871   1.00 33.66 ? 826  HOH A O   1 
HETATM 2712 O  O   . HOH C 3 .   ? -14.686 -34.205 -1.071  1.00 18.03 ? 827  HOH A O   1 
HETATM 2713 O  O   . HOH C 3 .   ? -25.560 -36.135 10.144  1.00 15.87 ? 828  HOH A O   1 
HETATM 2714 O  O   . HOH C 3 .   ? -6.637  -33.521 20.652  1.00 18.74 ? 829  HOH A O   1 
HETATM 2715 O  O   . HOH C 3 .   ? -11.364 -25.057 1.236   1.00 24.09 ? 830  HOH A O   1 
HETATM 2716 O  O   . HOH C 3 .   ? -16.100 -52.111 11.408  1.00 14.07 ? 831  HOH A O   1 
HETATM 2717 O  O   . HOH C 3 .   ? -10.482 -71.289 -4.546  1.00 46.84 ? 832  HOH A O   1 
HETATM 2718 O  O   . HOH C 3 .   ? -25.258 -41.065 19.197  1.00 34.92 ? 833  HOH A O   1 
HETATM 2719 O  O   . HOH C 3 .   ? -10.250 -37.830 -4.340  1.00 18.45 ? 834  HOH A O   1 
HETATM 2720 O  O   C HOH C 3 .   ? -12.510 -15.876 16.442  0.57 30.71 ? 835  HOH A O   1 
HETATM 2721 O  O   . HOH C 3 .   ? -3.553  -36.770 -2.481  1.00 17.43 ? 836  HOH A O   1 
HETATM 2722 O  O   . HOH C 3 .   ? -11.574 -54.000 5.547   1.00 11.50 ? 837  HOH A O   1 
HETATM 2723 O  O   . HOH C 3 .   ? -3.426  -42.929 4.920   1.00 14.98 ? 838  HOH A O   1 
HETATM 2724 O  O   . HOH C 3 .   ? -19.535 -39.026 25.302  1.00 17.00 ? 839  HOH A O   1 
HETATM 2725 O  O   . HOH C 3 .   ? -24.978 -44.857 1.777   1.00 18.02 ? 840  HOH A O   1 
HETATM 2726 O  O   . HOH C 3 .   ? -24.726 -48.601 17.872  1.00 24.34 ? 841  HOH A O   1 
HETATM 2727 O  O   . HOH C 3 .   ? 0.410   -49.296 0.518   1.00 20.38 ? 842  HOH A O   1 
HETATM 2728 O  O   . HOH C 3 .   ? -19.628 -70.383 -0.279  1.00 42.81 ? 843  HOH A O   1 
HETATM 2729 O  O   . HOH C 3 .   ? -29.152 -44.236 13.728  1.00 38.89 ? 844  HOH A O   1 
HETATM 2730 O  O   . HOH C 3 .   ? -15.544 -19.525 1.709   1.00 33.68 ? 845  HOH A O   1 
HETATM 2731 O  O   . HOH C 3 .   ? -4.230  -51.952 17.465  1.00 25.45 ? 846  HOH A O   1 
HETATM 2732 O  O   . HOH C 3 .   ? -12.467 -68.685 -4.509  1.00 26.99 ? 847  HOH A O   1 
HETATM 2733 O  O   . HOH C 3 .   ? -28.202 -26.118 6.528   1.00 27.62 ? 848  HOH A O   1 
HETATM 2734 O  O   . HOH C 3 .   ? -23.324 -21.578 22.344  1.00 20.59 ? 849  HOH A O   1 
HETATM 2735 O  O   . HOH C 3 .   ? -9.970  -55.872 18.917  1.00 29.36 ? 850  HOH A O   1 
HETATM 2736 O  O   . HOH C 3 .   ? -30.159 -38.366 16.252  1.00 33.27 ? 851  HOH A O   1 
HETATM 2737 O  O   . HOH C 3 .   ? -0.351  -65.768 3.478   1.00 23.61 ? 852  HOH A O   1 
HETATM 2738 O  O   . HOH C 3 .   ? -19.109 -41.375 2.022   1.00 21.78 ? 853  HOH A O   1 
HETATM 2739 O  O   . HOH C 3 .   ? -2.933  -39.455 -3.313  1.00 18.91 ? 854  HOH A O   1 
HETATM 2740 O  O   . HOH C 3 .   ? -23.875 -69.013 -1.862  1.00 41.30 ? 855  HOH A O   1 
HETATM 2741 O  O   . HOH C 3 .   ? 1.084   -62.222 5.474   1.00 27.44 ? 856  HOH A O   1 
HETATM 2742 O  O   . HOH C 3 .   ? 2.961   -47.260 5.626   1.00 45.63 ? 857  HOH A O   1 
HETATM 2743 O  O   . HOH C 3 .   ? 3.388   -38.323 -5.170  1.00 32.26 ? 858  HOH A O   1 
HETATM 2744 O  O   . HOH C 3 .   ? -21.761 -63.402 -9.341  1.00 36.84 ? 859  HOH A O   1 
HETATM 2745 O  O   . HOH C 3 .   ? -19.094 -54.666 -3.878  1.00 21.98 ? 860  HOH A O   1 
HETATM 2746 O  O   A HOH C 3 .   ? -13.484 -62.683 13.106  1.00 24.24 ? 861  HOH A O   1 
HETATM 2747 O  O   . HOH C 3 .   ? -16.917 -64.723 15.124  1.00 24.04 ? 862  HOH A O   1 
HETATM 2748 O  O   . HOH C 3 .   ? -30.651 -26.671 12.290  1.00 49.52 ? 863  HOH A O   1 
HETATM 2749 O  O   . HOH C 3 .   ? -3.006  -54.364 4.523   1.00 15.44 ? 864  HOH A O   1 
HETATM 2750 O  O   . HOH C 3 .   ? -32.229 -33.478 12.908  1.00 46.69 ? 865  HOH A O   1 
HETATM 2751 O  O   A HOH C 3 .   ? -17.921 -47.376 -12.091 0.75 24.40 ? 866  HOH A O   1 
HETATM 2752 O  O   . HOH C 3 .   ? 2.681   -27.363 -7.094  1.00 40.09 ? 867  HOH A O   1 
HETATM 2753 O  O   . HOH C 3 .   ? -29.886 -25.930 10.201  1.00 25.66 ? 868  HOH A O   1 
HETATM 2754 O  O   . HOH C 3 .   ? -20.113 -32.137 15.884  1.00 14.87 ? 869  HOH A O   1 
HETATM 2755 O  O   C HOH C 3 .   ? -15.919 -52.819 14.854  0.47 23.39 ? 870  HOH A O   1 
HETATM 2756 O  O   . HOH C 3 .   ? -14.963 -55.089 -14.609 1.00 35.17 ? 871  HOH A O   1 
HETATM 2757 O  O   . HOH C 3 .   ? -17.498 -31.704 3.458   1.00 18.96 ? 872  HOH A O   1 
HETATM 2758 O  O   . HOH C 3 .   ? -3.238  -39.188 19.093  1.00 41.05 ? 873  HOH A O   1 
HETATM 2759 O  O   . HOH C 3 .   ? -7.529  -64.869 -9.731  0.92 49.11 ? 874  HOH A O   1 
HETATM 2760 O  O   . HOH C 3 .   ? 3.454   -38.573 -0.709  1.00 35.82 ? 875  HOH A O   1 
HETATM 2761 O  O   . HOH C 3 .   ? -15.137 -18.256 19.840  1.00 21.79 ? 876  HOH A O   1 
HETATM 2762 O  O   . HOH C 3 .   ? -16.499 -26.708 2.684   1.00 17.06 ? 877  HOH A O   1 
HETATM 2763 O  O   . HOH C 3 .   ? -23.752 -43.222 -2.200  1.00 15.88 ? 878  HOH A O   1 
HETATM 2764 O  O   . HOH C 3 .   ? -19.200 -34.511 14.331  1.00 15.08 ? 879  HOH A O   1 
HETATM 2765 O  O   . HOH C 3 .   ? -19.912 -24.201 2.849   1.00 17.91 ? 880  HOH A O   1 
HETATM 2766 O  O   . HOH C 3 .   ? -20.347 -67.674 15.627  1.00 34.65 ? 881  HOH A O   1 
HETATM 2767 O  O   A HOH C 3 .   ? -11.028 -67.770 -8.834  0.66 29.81 ? 882  HOH A O   1 
HETATM 2768 O  O   . HOH C 3 .   ? -5.350  -34.831 18.650  1.00 20.14 ? 883  HOH A O   1 
HETATM 2769 O  O   . HOH C 3 .   ? -12.368 -11.570 9.986   1.00 39.55 ? 884  HOH A O   1 
HETATM 2770 O  O   . HOH C 3 .   ? -6.216  -50.334 19.865  1.00 35.83 ? 885  HOH A O   1 
HETATM 2771 O  O   . HOH C 3 .   ? -24.721 -60.519 9.530   1.00 18.11 ? 886  HOH A O   1 
HETATM 2772 O  O   A HOH C 3 .   ? -25.977 -31.237 8.939   0.61 23.14 ? 887  HOH A O   1 
HETATM 2773 O  O   . HOH C 3 .   ? -5.698  -43.827 6.329   1.00 13.47 ? 888  HOH A O   1 
HETATM 2774 O  O   . HOH C 3 .   ? -26.343 -40.382 8.826   1.00 15.58 ? 889  HOH A O   1 
HETATM 2775 O  O   . HOH C 3 .   ? 5.740   -62.667 -1.120  1.00 33.51 ? 890  HOH A O   1 
HETATM 2776 O  O   . HOH C 3 .   ? -3.387  -24.402 2.902   1.00 32.52 ? 891  HOH A O   1 
HETATM 2777 O  O   . HOH C 3 .   ? -9.583  -48.649 18.998  1.00 22.18 ? 892  HOH A O   1 
HETATM 2778 O  O   . HOH C 3 .   ? -36.302 -59.754 5.604   1.00 50.50 ? 893  HOH A O   1 
HETATM 2779 O  O   . HOH C 3 .   ? -6.986  -65.291 -6.044  1.00 30.03 ? 894  HOH A O   1 
HETATM 2780 O  O   . HOH C 3 .   ? -13.773 -11.303 5.393   1.00 56.99 ? 895  HOH A O   1 
HETATM 2781 O  O   . HOH C 3 .   ? -16.121 -72.901 0.688   1.00 38.40 ? 896  HOH A O   1 
HETATM 2782 O  O   . HOH C 3 .   ? -8.339  -65.918 -3.135  1.00 19.29 ? 897  HOH A O   1 
HETATM 2783 O  O   B HOH C 3 .   ? -28.750 -37.982 18.768  0.83 35.35 ? 898  HOH A O   1 
HETATM 2784 O  O   . HOH C 3 .   ? -5.802  -21.405 19.126  1.00 33.21 ? 899  HOH A O   1 
HETATM 2785 O  O   . HOH C 3 .   ? 3.541   -39.239 12.207  1.00 50.40 ? 900  HOH A O   1 
HETATM 2786 O  O   . HOH C 3 .   ? -23.053 -46.188 23.274  1.00 48.00 ? 901  HOH A O   1 
HETATM 2787 O  O   . HOH C 3 .   ? -24.819 -27.210 7.190   1.00 16.52 ? 902  HOH A O   1 
HETATM 2788 O  O   . HOH C 3 .   ? -29.156 -13.150 13.069  1.00 41.32 ? 903  HOH A O   1 
HETATM 2789 O  O   . HOH C 3 .   ? -21.585 -31.153 23.744  1.00 20.37 ? 904  HOH A O   1 
HETATM 2790 O  O   . HOH C 3 .   ? -22.315 -59.101 13.165  1.00 20.20 ? 905  HOH A O   1 
HETATM 2791 O  O   . HOH C 3 .   ? -22.868 -43.616 0.997   1.00 22.52 ? 906  HOH A O   1 
HETATM 2792 O  O   . HOH C 3 .   ? -27.396 -51.137 -0.639  1.00 29.22 ? 907  HOH A O   1 
HETATM 2793 O  O   . HOH C 3 .   ? -2.283  -22.161 5.812   1.00 58.46 ? 908  HOH A O   1 
HETATM 2794 O  O   . HOH C 3 .   ? -6.870  -42.800 12.226  1.00 18.95 ? 909  HOH A O   1 
HETATM 2795 O  O   . HOH C 3 .   ? -9.124  -10.889 7.688   1.00 44.58 ? 910  HOH A O   1 
HETATM 2796 O  O   . HOH C 3 .   ? -26.689 -13.934 20.580  1.00 29.62 ? 911  HOH A O   1 
HETATM 2797 O  O   . HOH C 3 .   ? -1.052  -33.885 9.404   1.00 24.44 ? 912  HOH A O   1 
HETATM 2798 O  O   . HOH C 3 .   ? -1.096  -66.249 0.898   1.00 23.08 ? 913  HOH A O   1 
HETATM 2799 O  O   . HOH C 3 .   ? -24.221 -66.524 16.145  1.00 42.41 ? 914  HOH A O   1 
HETATM 2800 O  O   . HOH C 3 .   ? -9.146  -52.459 20.628  1.00 26.61 ? 915  HOH A O   1 
HETATM 2801 O  O   . HOH C 3 .   ? -14.448 -67.525 -11.969 1.00 32.45 ? 916  HOH A O   1 
HETATM 2802 O  O   . HOH C 3 .   ? -18.909 -8.481  9.162   1.00 52.59 ? 917  HOH A O   1 
HETATM 2803 O  O   . HOH C 3 .   ? -7.740  -38.129 24.191  1.00 29.91 ? 918  HOH A O   1 
HETATM 2804 O  O   . HOH C 3 .   ? -3.245  -42.096 17.997  1.00 34.24 ? 919  HOH A O   1 
HETATM 2805 O  O   . HOH C 3 .   ? -10.491 -66.444 10.952  1.00 17.97 ? 920  HOH A O   1 
HETATM 2806 O  O   . HOH C 3 .   ? -7.444  -64.612 0.129   1.00 14.98 ? 921  HOH A O   1 
HETATM 2807 O  O   . HOH C 3 .   ? 0.100   -32.925 -2.643  1.00 21.04 ? 922  HOH A O   1 
HETATM 2808 O  O   . HOH C 3 .   ? -3.618  -21.045 7.529   1.00 53.24 ? 923  HOH A O   1 
HETATM 2809 O  O   . HOH C 3 .   ? -19.258 -41.446 10.281  1.00 14.47 ? 924  HOH A O   1 
HETATM 2810 O  O   . HOH C 3 .   ? 0.826   -62.174 -1.697  1.00 27.48 ? 925  HOH A O   1 
HETATM 2811 O  O   . HOH C 3 .   ? 1.254   -52.379 12.244  1.00 28.21 ? 926  HOH A O   1 
HETATM 2812 O  O   . HOH C 3 .   ? -8.600  -19.532 3.030   1.00 52.86 ? 927  HOH A O   1 
HETATM 2813 O  O   . HOH C 3 .   ? 0.223   -30.090 8.186   1.00 29.80 ? 928  HOH A O   1 
HETATM 2814 O  O   . HOH C 3 .   ? -3.916  -48.790 13.957  1.00 29.67 ? 929  HOH A O   1 
HETATM 2815 O  O   . HOH C 3 .   ? -13.541 -47.619 28.606  1.00 56.28 ? 930  HOH A O   1 
HETATM 2816 O  O   . HOH C 3 .   ? -26.784 -14.403 5.378   1.00 21.07 ? 931  HOH A O   1 
HETATM 2817 O  O   . HOH C 3 .   ? -23.707 -64.207 18.062  1.00 49.50 ? 932  HOH A O   1 
HETATM 2818 O  O   . HOH C 3 .   ? -13.524 -28.297 26.719  1.00 45.73 ? 933  HOH A O   1 
HETATM 2819 O  O   . HOH C 3 .   ? -30.039 -58.630 13.419  1.00 40.47 ? 934  HOH A O   1 
HETATM 2820 O  O   . HOH C 3 .   ? -28.759 -56.757 14.626  1.00 50.17 ? 935  HOH A O   1 
HETATM 2821 O  O   . HOH C 3 .   ? -5.097  -61.558 -6.730  1.00 38.63 ? 936  HOH A O   1 
HETATM 2822 O  O   . HOH C 3 .   ? 4.384   -30.904 2.590   1.00 41.20 ? 937  HOH A O   1 
HETATM 2823 O  O   . HOH C 3 .   ? -9.699  -13.319 13.011  1.00 51.99 ? 938  HOH A O   1 
HETATM 2824 O  O   . HOH C 3 .   ? -1.371  -41.406 6.075   1.00 20.62 ? 939  HOH A O   1 
HETATM 2825 O  O   . HOH C 3 .   ? -9.630  -55.963 -9.619  1.00 26.52 ? 940  HOH A O   1 
HETATM 2826 O  O   . HOH C 3 .   ? 0.768   -27.013 10.324  1.00 41.23 ? 941  HOH A O   1 
HETATM 2827 O  O   . HOH C 3 .   ? 3.019   -38.170 5.147   1.00 45.72 ? 942  HOH A O   1 
HETATM 2828 O  O   B HOH C 3 .   ? 7.697   -52.161 -6.055  0.62 28.24 ? 943  HOH A O   1 
HETATM 2829 O  O   . HOH C 3 .   ? -28.342 -17.188 19.165  1.00 35.05 ? 944  HOH A O   1 
HETATM 2830 O  O   . HOH C 3 .   ? -12.592 -50.101 22.391  1.00 29.02 ? 945  HOH A O   1 
HETATM 2831 O  O   . HOH C 3 .   ? -24.083 -26.859 26.717  1.00 54.13 ? 946  HOH A O   1 
HETATM 2832 O  O   . HOH C 3 .   ? -32.227 -31.607 15.571  1.00 41.32 ? 947  HOH A O   1 
HETATM 2833 O  O   . HOH C 3 .   ? -23.882 -28.729 25.018  1.00 37.73 ? 948  HOH A O   1 
HETATM 2834 O  O   . HOH C 3 .   ? -16.763 -65.653 -15.446 1.00 52.01 ? 949  HOH A O   1 
HETATM 2835 O  O   . HOH C 3 .   ? -3.170  -56.523 8.241   1.00 19.69 ? 950  HOH A O   1 
HETATM 2836 O  O   . HOH C 3 .   ? -7.992  -24.322 25.141  1.00 48.57 ? 951  HOH A O   1 
HETATM 2837 O  O   . HOH C 3 .   ? -10.031 -18.597 7.454   1.00 25.23 ? 952  HOH A O   1 
HETATM 2838 O  O   . HOH C 3 .   ? -0.157  -61.708 7.840   1.00 38.64 ? 953  HOH A O   1 
HETATM 2839 O  O   . HOH C 3 .   ? 4.489   -56.405 8.567   1.00 29.66 ? 954  HOH A O   1 
HETATM 2840 O  O   . HOH C 3 .   ? -6.606  -72.582 -3.362  1.00 42.63 ? 955  HOH A O   1 
HETATM 2841 O  O   . HOH C 3 .   ? -27.704 -26.830 20.898  1.00 30.81 ? 956  HOH A O   1 
HETATM 2842 O  O   . HOH C 3 .   ? -24.574 -42.563 30.788  0.50 42.18 ? 957  HOH A O   1 
HETATM 2843 O  O   B HOH C 3 .   ? -19.270 -67.577 -9.517  0.83 38.64 ? 958  HOH A O   1 
HETATM 2844 O  O   . HOH C 3 .   ? -22.718 -22.469 24.717  1.00 33.70 ? 959  HOH A O   1 
HETATM 2845 O  O   . HOH C 3 .   ? -24.837 -15.029 2.284   1.00 18.42 ? 960  HOH A O   1 
HETATM 2846 O  O   . HOH C 3 .   ? 4.011   -31.462 11.633  1.00 36.17 ? 961  HOH A O   1 
HETATM 2847 O  O   . HOH C 3 .   ? -33.469 -50.736 8.924   1.00 24.70 ? 962  HOH A O   1 
HETATM 2848 O  O   . HOH C 3 .   ? -13.563 -47.848 8.394   1.00 13.69 ? 963  HOH A O   1 
HETATM 2849 O  O   B HOH C 3 .   ? -10.107 -74.201 3.109   0.97 39.95 ? 964  HOH A O   1 
HETATM 2850 O  O   . HOH C 3 .   ? -3.068  -27.261 21.894  1.00 30.90 ? 965  HOH A O   1 
HETATM 2851 O  O   A HOH C 3 .   ? -6.648  -30.776 26.411  1.00 40.10 ? 966  HOH A O   1 
HETATM 2852 O  O   B HOH C 3 .   ? -24.511 -38.198 23.173  1.00 23.67 ? 967  HOH A O   1 
HETATM 2853 O  O   . HOH C 3 .   ? 2.785   -41.485 7.205   1.00 39.35 ? 968  HOH A O   1 
HETATM 2854 O  O   . HOH C 3 .   ? -4.029  -22.913 14.938  1.00 38.75 ? 969  HOH A O   1 
HETATM 2855 O  O   . HOH C 3 .   ? 3.051   -52.336 9.213   1.00 27.23 ? 970  HOH A O   1 
HETATM 2856 O  O   . HOH C 3 .   ? 6.109   -35.224 -2.832  1.00 47.98 ? 971  HOH A O   1 
HETATM 2857 O  O   . HOH C 3 .   ? -5.653  -47.497 12.212  1.00 18.67 ? 972  HOH A O   1 
HETATM 2858 O  O   . HOH C 3 .   ? -24.904 -26.397 21.663  1.00 30.39 ? 973  HOH A O   1 
HETATM 2859 O  O   . HOH C 3 .   ? -10.249 -41.242 -4.449  1.00 14.50 ? 974  HOH A O   1 
HETATM 2860 O  O   . HOH C 3 .   ? -12.343 -55.492 -15.844 1.00 50.59 ? 975  HOH A O   1 
HETATM 2861 O  O   . HOH C 3 .   ? -18.148 -48.439 19.649  1.00 23.35 ? 976  HOH A O   1 
HETATM 2862 O  O   . HOH C 3 .   ? -25.958 -48.942 0.192   1.00 22.74 ? 977  HOH A O   1 
HETATM 2863 O  O   . HOH C 3 .   ? -13.065 -66.015 16.878  1.00 29.90 ? 978  HOH A O   1 
HETATM 2864 O  O   . HOH C 3 .   ? 6.331   -29.579 -4.311  1.00 32.15 ? 979  HOH A O   1 
HETATM 2865 O  O   . HOH C 3 .   ? -27.893 -65.713 14.352  1.00 48.99 ? 980  HOH A O   1 
HETATM 2866 O  O   . HOH C 3 .   ? -27.283 -64.992 6.375   1.00 20.06 ? 981  HOH A O   1 
HETATM 2867 O  O   . HOH C 3 .   ? -22.828 -28.055 3.101   1.00 14.34 ? 982  HOH A O   1 
HETATM 2868 O  O   A HOH C 3 .   ? -18.977 -65.882 -10.422 0.47 33.36 ? 983  HOH A O   1 
HETATM 2869 O  O   A HOH C 3 .   ? -10.488 -74.366 5.120   0.85 29.91 ? 984  HOH A O   1 
HETATM 2870 O  O   . HOH C 3 .   ? -11.273 -16.054 19.450  1.00 39.36 ? 985  HOH A O   1 
HETATM 2871 O  O   . HOH C 3 .   ? -25.179 -63.230 -1.590  1.00 34.31 ? 986  HOH A O   1 
HETATM 2872 O  O   . HOH C 3 .   ? -11.506 -61.188 -15.338 1.00 51.30 ? 987  HOH A O   1 
HETATM 2873 O  O   . HOH C 3 .   ? 6.633   -33.641 -8.152  1.00 37.33 ? 988  HOH A O   1 
HETATM 2874 O  O   . HOH C 3 .   ? -1.475  -30.608 21.322  1.00 28.57 ? 989  HOH A O   1 
HETATM 2875 O  O   . HOH C 3 .   ? -27.353 -12.784 11.012  1.00 50.29 ? 990  HOH A O   1 
HETATM 2876 O  O   B HOH C 3 .   ? -23.015 -44.634 15.769  1.00 16.32 ? 991  HOH A O   1 
HETATM 2877 O  O   . HOH C 3 .   ? -5.979  -55.698 19.268  1.00 45.05 ? 992  HOH A O   1 
HETATM 2878 O  O   . HOH C 3 .   ? 3.789   -28.395 8.471   1.00 56.28 ? 993  HOH A O   1 
HETATM 2879 O  O   . HOH C 3 .   ? -31.333 -33.720 21.371  1.00 31.28 ? 994  HOH A O   1 
HETATM 2880 O  O   C HOH C 3 .   ? -28.822 -27.609 18.198  0.62 28.86 ? 995  HOH A O   1 
HETATM 2881 O  O   . HOH C 3 .   ? -23.888 -70.098 4.828   1.00 28.84 ? 996  HOH A O   1 
HETATM 2882 O  O   . HOH C 3 .   ? 0.348   -45.458 8.398   1.00 24.44 ? 997  HOH A O   1 
HETATM 2883 O  O   . HOH C 3 .   ? 5.247   -56.150 -0.090  1.00 26.75 ? 998  HOH A O   1 
HETATM 2884 O  O   C HOH C 3 .   ? -14.038 -17.136 3.098   0.94 26.68 ? 999  HOH A O   1 
HETATM 2885 O  O   . HOH C 3 .   ? -22.402 -12.600 20.893  1.00 32.68 ? 1000 HOH A O   1 
HETATM 2886 O  O   . HOH C 3 .   ? -0.710  -41.869 1.823   1.00 23.91 ? 1001 HOH A O   1 
HETATM 2887 O  O   . HOH C 3 .   ? -2.610  -17.414 13.185  1.00 39.38 ? 1002 HOH A O   1 
HETATM 2888 O  O   . HOH C 3 .   ? -10.124 -23.304 4.509   1.00 30.71 ? 1003 HOH A O   1 
HETATM 2889 O  O   . HOH C 3 .   ? -15.099 -14.031 3.934   1.00 31.78 ? 1004 HOH A O   1 
HETATM 2890 O  O   . HOH C 3 .   ? -19.450 -70.893 11.797  1.00 23.98 ? 1005 HOH A O   1 
HETATM 2891 O  O   . HOH C 3 .   ? -33.654 -57.767 10.183  1.00 34.91 ? 1006 HOH A O   1 
HETATM 2892 O  O   . HOH C 3 .   ? -2.290  -61.794 10.837  1.00 31.88 ? 1007 HOH A O   1 
HETATM 2893 O  O   . HOH C 3 .   ? -8.023  -41.793 20.740  1.00 38.79 ? 1008 HOH A O   1 
HETATM 2894 O  O   . HOH C 3 .   ? -1.690  -54.435 6.957   1.00 18.02 ? 1009 HOH A O   1 
HETATM 2895 O  O   B HOH C 3 .   ? -20.206 -59.577 -13.481 0.62 39.67 ? 1010 HOH A O   1 
HETATM 2896 O  O   . HOH C 3 .   ? -26.621 -49.226 15.286  1.00 22.94 ? 1011 HOH A O   1 
HETATM 2897 O  O   . HOH C 3 .   ? 3.887   -36.737 -3.062  1.00 19.77 ? 1012 HOH A O   1 
HETATM 2898 O  O   . HOH C 3 .   ? -17.749 -13.091 20.098  1.00 51.89 ? 1013 HOH A O   1 
HETATM 2899 O  O   . HOH C 3 .   ? -7.236  -41.096 24.265  1.00 51.48 ? 1014 HOH A O   1 
HETATM 2900 O  O   . HOH C 3 .   ? -18.174 -29.348 28.891  1.00 42.20 ? 1015 HOH A O   1 
HETATM 2901 O  O   . HOH C 3 .   ? 1.227   -33.336 10.827  1.00 32.80 ? 1016 HOH A O   1 
HETATM 2902 O  O   A HOH C 3 .   ? -6.071  -62.127 -11.139 1.00 50.01 ? 1017 HOH A O   1 
HETATM 2903 O  O   B HOH C 3 .   ? -6.893  -61.868 -8.866  1.00 38.54 ? 1018 HOH A O   1 
HETATM 2904 O  O   . HOH C 3 .   ? -15.617 -31.990 0.349   1.00 22.31 ? 1019 HOH A O   1 
HETATM 2905 O  O   . HOH C 3 .   ? -18.079 -41.979 31.291  1.00 40.01 ? 1020 HOH A O   1 
HETATM 2906 O  O   . HOH C 3 .   ? -19.597 -33.390 2.242   1.00 25.17 ? 1021 HOH A O   1 
HETATM 2907 O  O   . HOH C 3 .   ? -5.109  -20.455 1.766   1.00 47.52 ? 1022 HOH A O   1 
HETATM 2908 O  O   . HOH C 3 .   ? -18.522 -72.861 2.742   1.00 43.38 ? 1023 HOH A O   1 
HETATM 2909 O  O   . HOH C 3 .   ? 1.353   -38.252 3.087   1.00 37.61 ? 1024 HOH A O   1 
HETATM 2910 O  O   . HOH C 3 .   ? -10.309 -57.941 15.315  1.00 30.35 ? 1025 HOH A O   1 
HETATM 2911 O  O   . HOH C 3 .   ? -25.539 -11.658 12.435  1.00 42.71 ? 1026 HOH A O   1 
HETATM 2912 O  O   . HOH C 3 .   ? -1.269  -31.170 25.909  1.00 48.49 ? 1027 HOH A O   1 
HETATM 2913 O  O   B HOH C 3 .   ? -13.113 -38.409 -4.575  0.83 16.78 ? 1028 HOH A O   1 
HETATM 2914 O  O   . HOH C 3 .   ? -21.483 -45.268 -12.803 1.00 49.71 ? 1029 HOH A O   1 
HETATM 2915 O  O   . HOH C 3 .   ? 7.346   -31.491 -2.577  1.00 56.15 ? 1030 HOH A O   1 
HETATM 2916 O  O   . HOH C 3 .   ? -34.200 -60.941 10.725  1.00 33.66 ? 1031 HOH A O   1 
HETATM 2917 O  O   . HOH C 3 .   ? -18.320 -12.633 14.604  1.00 28.68 ? 1032 HOH A O   1 
HETATM 2918 O  O   A HOH C 3 .   ? -29.380 -37.984 11.655  0.47 28.25 ? 1033 HOH A O   1 
HETATM 2919 O  O   . HOH C 3 .   ? 6.860   -50.427 1.213   1.00 54.38 ? 1034 HOH A O   1 
HETATM 2920 O  O   B HOH C 3 .   ? -9.034  -19.988 22.939  0.71 32.44 ? 1035 HOH A O   1 
HETATM 2921 O  O   B HOH C 3 .   ? -31.187 -37.503 11.998  0.58 23.87 ? 1036 HOH A O   1 
HETATM 2922 O  O   . HOH C 3 .   ? -2.669  -20.492 10.726  1.00 49.48 ? 1037 HOH A O   1 
HETATM 2923 O  O   . HOH C 3 .   ? -20.985 -25.327 27.267  1.00 42.90 ? 1038 HOH A O   1 
HETATM 2924 O  O   . HOH C 3 .   ? -1.942  -22.841 -0.920  1.00 39.22 ? 1039 HOH A O   1 
HETATM 2925 O  O   . HOH C 3 .   ? -15.023 -59.941 14.139  1.00 17.88 ? 1040 HOH A O   1 
HETATM 2926 O  O   . HOH C 3 .   ? -20.048 -43.660 30.127  1.00 42.73 ? 1041 HOH A O   1 
HETATM 2927 O  O   . HOH C 3 .   ? -31.794 -49.593 10.640  1.00 26.02 ? 1042 HOH A O   1 
HETATM 2928 O  O   B HOH C 3 .   ? -15.834 -39.815 31.481  1.00 37.61 ? 1043 HOH A O   1 
HETATM 2929 O  O   . HOH C 3 .   ? 0.319   -39.478 -6.623  1.00 38.17 ? 1044 HOH A O   1 
HETATM 2930 O  O   . HOH C 3 .   ? -2.609  -34.996 19.283  1.00 33.48 ? 1045 HOH A O   1 
HETATM 2931 O  O   . HOH C 3 .   ? -21.410 -50.510 -13.097 1.00 36.83 ? 1046 HOH A O   1 
HETATM 2932 O  O   . HOH C 3 .   ? -4.770  -48.338 9.575   1.00 16.96 ? 1047 HOH A O   1 
HETATM 2933 O  O   . HOH C 3 .   ? -21.331 -56.769 -13.104 1.00 48.11 ? 1048 HOH A O   1 
HETATM 2934 O  O   . HOH C 3 .   ? -32.191 -55.339 14.755  1.00 47.54 ? 1049 HOH A O   1 
HETATM 2935 O  O   . HOH C 3 .   ? -0.894  -62.604 -5.745  1.00 50.43 ? 1050 HOH A O   1 
HETATM 2936 O  O   B HOH C 3 .   ? -23.843 -34.303 2.657   0.89 38.26 ? 1051 HOH A O   1 
HETATM 2937 O  O   . HOH C 3 .   ? 0.671   -43.087 6.954   1.00 32.44 ? 1052 HOH A O   1 
HETATM 2938 O  O   B HOH C 3 .   ? -24.052 -40.394 24.859  1.00 42.98 ? 1053 HOH A O   1 
HETATM 2939 O  O   . HOH C 3 .   ? -23.760 -10.795 10.467  1.00 50.81 ? 1054 HOH A O   1 
HETATM 2940 O  O   . HOH C 3 .   ? -1.104  -46.706 13.070  1.00 44.06 ? 1055 HOH A O   1 
HETATM 2941 O  O   . HOH C 3 .   ? -24.200 -45.022 28.768  1.00 53.72 ? 1056 HOH A O   1 
HETATM 2942 O  O   . HOH C 3 .   ? -33.663 -24.192 15.749  1.00 53.31 ? 1057 HOH A O   1 
HETATM 2943 O  O   . HOH C 3 .   ? -4.879  -45.204 15.908  1.00 21.32 ? 1058 HOH A O   1 
HETATM 2944 O  O   . HOH C 3 .   ? -31.279 -54.177 0.000   0.50 38.33 ? 1059 HOH A O   1 
HETATM 2945 O  O   . HOH C 3 .   ? -0.737  -57.148 14.945  1.00 45.53 ? 1060 HOH A O   1 
HETATM 2946 O  O   . HOH C 3 .   ? -20.492 -47.261 23.080  1.00 46.58 ? 1061 HOH A O   1 
HETATM 2947 O  O   . HOH C 3 .   ? -29.489 -18.453 17.185  1.00 31.09 ? 1062 HOH A O   1 
HETATM 2948 O  O   B HOH C 3 .   ? -9.665  -67.016 -8.237  0.74 36.63 ? 1063 HOH A O   1 
HETATM 2949 O  O   . HOH C 3 .   ? -11.757 -58.036 -17.008 1.00 49.26 ? 1064 HOH A O   1 
HETATM 2950 O  O   B HOH C 3 .   ? -3.364  -67.329 5.729   0.52 26.76 ? 1065 HOH A O   1 
HETATM 2951 O  O   A HOH C 3 .   ? 1.159   -59.014 -5.330  1.00 27.73 ? 1066 HOH A O   1 
HETATM 2952 O  O   . HOH C 3 .   ? 8.407   -52.434 -2.138  1.00 49.52 ? 1067 HOH A O   1 
HETATM 2953 O  O   B HOH C 3 .   ? -30.699 -27.755 18.084  0.62 32.46 ? 1068 HOH A O   1 
HETATM 2954 O  O   . HOH C 3 .   ? -23.212 -68.613 14.366  1.00 43.68 ? 1069 HOH A O   1 
HETATM 2955 O  O   A HOH C 3 .   ? -0.999  -52.215 14.046  0.85 30.35 ? 1070 HOH A O   1 
HETATM 2956 O  O   . HOH C 3 .   ? 6.731   -34.748 -0.030  1.00 53.62 ? 1071 HOH A O   1 
HETATM 2957 O  O   . HOH C 3 .   ? -17.407 -20.425 27.752  1.00 57.96 ? 1072 HOH A O   1 
HETATM 2958 O  O   . HOH C 3 .   ? -20.536 -64.292 -11.742 1.00 50.06 ? 1073 HOH A O   1 
HETATM 2959 O  O   . HOH C 3 .   ? -36.746 -60.665 9.159   1.00 50.42 ? 1074 HOH A O   1 
HETATM 2960 O  O   . HOH C 3 .   ? -1.631  -23.637 11.440  1.00 54.36 ? 1075 HOH A O   1 
HETATM 2961 O  O   D HOH C 3 .   ? -16.184 -73.963 7.566   1.00 26.36 ? 1076 HOH A O   1 
HETATM 2962 O  O   . HOH C 3 .   ? -25.401 -68.463 1.887   1.00 50.24 ? 1077 HOH A O   1 
HETATM 2963 O  O   . HOH C 3 .   ? -24.480 -49.738 20.256  1.00 55.92 ? 1078 HOH A O   1 
HETATM 2964 O  O   . HOH C 3 .   ? -25.610 -36.543 13.024  1.00 17.87 ? 1079 HOH A O   1 
HETATM 2965 O  O   . HOH C 3 .   ? -0.406  -38.389 12.964  1.00 39.19 ? 1080 HOH A O   1 
HETATM 2966 O  O   . HOH C 3 .   ? 0.006   -23.314 6.834   1.00 50.43 ? 1081 HOH A O   1 
HETATM 2967 O  O   . HOH C 3 .   ? 5.605   -49.322 7.869   1.00 51.21 ? 1082 HOH A O   1 
HETATM 2968 O  O   . HOH C 3 .   ? -19.955 -12.199 19.012  1.00 49.96 ? 1083 HOH A O   1 
HETATM 2969 O  O   . HOH C 3 .   ? -34.631 -54.429 8.190   1.00 46.53 ? 1084 HOH A O   1 
HETATM 2970 O  O   . HOH C 3 .   ? -16.691 -63.978 -19.349 1.00 51.62 ? 1085 HOH A O   1 
HETATM 2971 O  O   . HOH C 3 .   ? -27.756 -36.801 24.464  1.00 48.27 ? 1086 HOH A O   1 
HETATM 2972 O  O   . HOH C 3 .   ? 3.918   -29.270 -6.934  1.00 50.25 ? 1087 HOH A O   1 
HETATM 2973 O  O   . HOH C 3 .   ? -29.490 -23.793 19.299  1.00 51.60 ? 1088 HOH A O   1 
HETATM 2974 O  O   . HOH C 3 .   ? -31.581 -66.741 6.749   1.00 44.80 ? 1089 HOH A O   1 
HETATM 2975 O  O   . HOH C 3 .   ? 2.256   -47.399 7.872   1.00 38.92 ? 1090 HOH A O   1 
HETATM 2976 O  O   B HOH C 3 .   ? -19.720 -29.385 27.327  0.47 31.41 ? 1091 HOH A O   1 
HETATM 2977 O  O   A HOH C 3 .   ? -21.912 -45.271 17.754  1.00 32.63 ? 1092 HOH A O   1 
HETATM 2978 O  O   . HOH C 3 .   ? -16.806 -68.641 17.719  1.00 38.45 ? 1093 HOH A O   1 
HETATM 2979 O  O   . HOH C 3 .   ? -5.864  -22.886 2.793   1.00 31.98 ? 1094 HOH A O   1 
HETATM 2980 O  O   B HOH C 3 .   ? -12.625 -65.066 12.624  0.90 37.49 ? 1095 HOH A O   1 
HETATM 2981 O  O   . HOH C 3 .   ? -34.444 -58.144 3.385   1.00 50.62 ? 1096 HOH A O   1 
HETATM 2982 O  O   . HOH C 3 .   ? -34.530 -55.901 4.717   1.00 46.38 ? 1097 HOH A O   1 
HETATM 2983 O  O   . HOH C 3 .   ? -16.016 -10.476 6.045   1.00 52.06 ? 1098 HOH A O   1 
HETATM 2984 O  O   B HOH C 3 .   ? -0.434  -35.643 17.706  1.00 58.38 ? 1099 HOH A O   1 
HETATM 2985 O  O   . HOH C 3 .   ? -36.828 -62.484 5.717   1.00 56.88 ? 1100 HOH A O   1 
HETATM 2986 O  O   . HOH C 3 .   ? -2.067  -45.120 4.372   1.00 15.80 ? 1101 HOH A O   1 
HETATM 2987 O  O   . HOH C 3 .   ? -28.807 -57.366 -10.188 1.00 48.82 ? 1102 HOH A O   1 
HETATM 2988 O  O   . HOH C 3 .   ? -24.270 -52.337 -10.081 1.00 34.31 ? 1103 HOH A O   1 
HETATM 2989 O  O   . HOH C 3 .   ? 0.488   -31.303 18.218  1.00 49.71 ? 1104 HOH A O   1 
HETATM 2990 O  O   . HOH C 3 .   ? 4.984   -38.537 1.529   1.00 55.71 ? 1105 HOH A O   1 
HETATM 2991 O  O   . HOH C 3 .   ? -13.161 -15.795 26.627  1.00 61.65 ? 1106 HOH A O   1 
HETATM 2992 O  O   . HOH C 3 .   ? -6.697  -45.369 13.524  1.00 19.36 ? 1107 HOH A O   1 
HETATM 2993 O  O   . HOH C 3 .   ? 8.167   -52.112 0.407   1.00 50.73 ? 1108 HOH A O   1 
HETATM 2994 O  O   . HOH C 3 .   ? -31.725 -60.316 1.981   1.00 49.16 ? 1109 HOH A O   1 
HETATM 2995 O  O   . HOH C 3 .   ? -30.187 -13.962 16.281  1.00 52.97 ? 1110 HOH A O   1 
HETATM 2996 O  O   B HOH C 3 .   ? -25.502 -31.543 25.917  0.88 39.83 ? 1111 HOH A O   1 
HETATM 2997 O  O   . HOH C 3 .   ? -25.405 -70.883 8.317   1.00 43.34 ? 1112 HOH A O   1 
HETATM 2998 O  O   . HOH C 3 .   ? 2.288   -28.321 4.629   1.00 45.98 ? 1113 HOH A O   1 
HETATM 2999 O  O   . HOH C 3 .   ? -17.691 -72.038 -1.352  1.00 50.33 ? 1114 HOH A O   1 
HETATM 3000 O  O   . HOH C 3 .   ? -20.453 -61.458 -16.886 1.00 50.78 ? 1115 HOH A O   1 
HETATM 3001 O  O   . HOH C 3 .   ? -28.456 -51.414 15.574  1.00 44.22 ? 1116 HOH A O   1 
HETATM 3002 O  O   . HOH C 3 .   ? -35.077 -53.820 5.823   1.00 39.62 ? 1117 HOH A O   1 
HETATM 3003 O  O   B HOH C 3 .   ? -30.338 -56.989 -0.535  0.99 33.56 ? 1118 HOH A O   1 
HETATM 3004 O  O   B HOH C 3 .   ? -32.530 -23.275 10.089  0.69 28.49 ? 1119 HOH A O   1 
HETATM 3005 O  O   . HOH C 3 .   ? -26.223 -19.410 23.875  1.00 42.88 ? 1120 HOH A O   1 
HETATM 3006 O  O   . HOH C 3 .   ? -21.329 -20.933 26.037  1.00 47.54 ? 1121 HOH A O   1 
HETATM 3007 O  O   A HOH C 3 .   ? -22.939 -39.341 23.684  1.00 28.19 ? 1122 HOH A O   1 
HETATM 3008 O  O   . HOH C 3 .   ? 0.715   -41.613 -0.575  1.00 34.01 ? 1123 HOH A O   1 
HETATM 3009 O  O   . HOH C 3 .   ? -19.873 -19.014 25.645  1.00 42.41 ? 1124 HOH A O   1 
HETATM 3010 O  O   . HOH C 3 .   ? -7.904  -67.402 -5.709  1.00 46.20 ? 1125 HOH A O   1 
HETATM 3011 O  O   . HOH C 3 .   ? -18.011 -8.587  6.407   1.00 54.59 ? 1126 HOH A O   1 
HETATM 3012 O  O   . HOH C 3 .   ? 3.959   -33.263 -11.457 1.00 49.51 ? 1127 HOH A O   1 
HETATM 3013 O  O   . HOH C 3 .   ? 1.495   -27.848 14.912  1.00 47.64 ? 1128 HOH A O   1 
HETATM 3014 O  O   . HOH C 3 .   ? -17.061 -69.268 -6.457  1.00 46.45 ? 1129 HOH A O   1 
HETATM 3015 O  O   B HOH C 3 .   ? -26.774 -64.256 0.052   0.69 38.30 ? 1130 HOH A O   1 
HETATM 3016 O  O   A HOH C 3 .   ? -0.412  -33.243 20.873  1.00 46.64 ? 1131 HOH A O   1 
HETATM 3017 O  O   . HOH C 3 .   ? -1.615  -59.081 10.102  1.00 38.63 ? 1132 HOH A O   1 
HETATM 3018 O  O   . HOH C 3 .   ? -4.077  -38.270 25.662  1.00 43.51 ? 1133 HOH A O   1 
HETATM 3019 O  O   . HOH C 3 .   ? 2.826   -63.296 -3.299  1.00 43.43 ? 1134 HOH A O   1 
HETATM 3020 O  O   B HOH C 3 .   ? -22.933 -36.813 0.363   1.00 40.91 ? 1135 HOH A O   1 
HETATM 3021 O  O   . HOH C 3 .   ? -3.804  -71.345 6.638   1.00 38.91 ? 1136 HOH A O   1 
HETATM 3022 O  O   . HOH C 3 .   ? -10.997 -27.879 25.173  1.00 44.74 ? 1137 HOH A O   1 
HETATM 3023 O  O   . HOH C 3 .   ? -27.229 -28.862 8.207   1.00 26.62 ? 1138 HOH A O   1 
HETATM 3024 O  O   . HOH C 3 .   ? -17.344 -22.150 32.037  1.00 61.51 ? 1139 HOH A O   1 
HETATM 3025 O  O   . HOH C 3 .   ? -16.333 -11.636 23.688  1.00 64.44 ? 1140 HOH A O   1 
HETATM 3026 O  O   . HOH C 3 .   ? -18.120 -10.153 4.332   1.00 55.34 ? 1141 HOH A O   1 
HETATM 3027 O  O   . HOH C 3 .   ? 3.219   -60.272 5.434   1.00 47.34 ? 1142 HOH A O   1 
HETATM 3028 O  O   . HOH C 3 .   ? -32.607 -30.561 18.127  1.00 47.42 ? 1143 HOH A O   1 
HETATM 3029 O  O   . HOH C 3 .   ? 2.518   -49.453 9.486   1.00 36.34 ? 1144 HOH A O   1 
HETATM 3030 O  O   . HOH C 3 .   ? -9.021  -40.791 22.808  1.00 34.16 ? 1145 HOH A O   1 
HETATM 3031 O  O   . HOH C 3 .   ? -2.172  -63.201 13.028  1.00 34.79 ? 1146 HOH A O   1 
HETATM 3032 O  O   . HOH C 3 .   ? -28.905 -46.980 15.371  1.00 48.01 ? 1147 HOH A O   1 
HETATM 3033 O  O   . HOH C 3 .   ? -14.715 -72.243 -5.033  1.00 49.20 ? 1148 HOH A O   1 
HETATM 3034 O  O   . HOH C 3 .   ? -19.833 -62.993 18.130  1.00 45.83 ? 1149 HOH A O   1 
HETATM 3035 O  O   . HOH C 3 .   ? -19.616 -70.503 -4.714  1.00 50.63 ? 1150 HOH A O   1 
HETATM 3036 O  O   . HOH C 3 .   ? -11.620 -11.810 12.855  1.00 59.27 ? 1151 HOH A O   1 
HETATM 3037 O  O   . HOH C 3 .   ? -23.841 -11.193 14.222  1.00 45.86 ? 1152 HOH A O   1 
HETATM 3038 O  O   . HOH C 3 .   ? -18.794 -65.026 16.722  1.00 38.28 ? 1153 HOH A O   1 
HETATM 3039 O  O   . HOH C 3 .   ? -0.261  -69.875 8.394   1.00 32.97 ? 1154 HOH A O   1 
HETATM 3040 O  O   . HOH C 3 .   ? -3.576  -20.098 15.629  1.00 51.16 ? 1155 HOH A O   1 
HETATM 3041 O  O   . HOH C 3 .   ? 5.829   -51.874 8.678   1.00 53.60 ? 1156 HOH A O   1 
HETATM 3042 O  O   A HOH C 3 .   ? -19.451 -54.241 -16.527 1.00 54.49 ? 1157 HOH A O   1 
HETATM 3043 O  O   . HOH C 3 .   ? -12.930 -72.824 -2.511  1.00 45.71 ? 1158 HOH A O   1 
HETATM 3044 O  O   . HOH C 3 .   ? -30.175 -66.484 12.731  1.00 58.49 ? 1159 HOH A O   1 
HETATM 3045 O  O   C HOH C 3 .   ? -27.236 -20.001 12.894  0.75 25.82 ? 1160 HOH A O   1 
HETATM 3046 O  O   . HOH C 3 .   ? -15.983 -66.904 16.564  1.00 44.02 ? 1161 HOH A O   1 
HETATM 3047 O  O   . HOH C 3 .   ? 0.135   -36.246 12.930  1.00 43.71 ? 1162 HOH A O   1 
HETATM 3048 O  O   . HOH C 3 .   ? -13.208 -50.816 -15.877 1.00 44.65 ? 1163 HOH A O   1 
HETATM 3049 O  O   B HOH C 3 .   ? -26.658 -39.521 17.716  0.70 37.10 ? 1164 HOH A O   1 
HETATM 3050 O  O   . HOH C 3 .   ? -21.216 -57.470 -18.371 1.00 57.72 ? 1165 HOH A O   1 
HETATM 3051 O  O   . HOH C 3 .   ? -2.373  -45.641 15.884  1.00 46.59 ? 1166 HOH A O   1 
HETATM 3052 O  O   . HOH C 3 .   ? -28.796 -12.378 8.482   1.00 51.26 ? 1167 HOH A O   1 
HETATM 3053 O  O   . HOH C 3 .   ? -9.428  -58.816 -15.617 1.00 43.28 ? 1168 HOH A O   1 
HETATM 3054 O  O   . HOH C 3 .   ? -26.800 -38.894 13.734  1.00 33.05 ? 1169 HOH A O   1 
HETATM 3055 O  O   . HOH C 3 .   ? 7.555   -49.652 -2.553  1.00 46.60 ? 1170 HOH A O   1 
HETATM 3056 O  O   . HOH C 3 .   ? 6.711   -61.024 0.579   1.00 42.70 ? 1171 HOH A O   1 
HETATM 3057 O  O   A HOH C 3 .   ? -22.006 -34.949 2.259   1.00 41.78 ? 1172 HOH A O   1 
HETATM 3058 O  O   A HOH C 3 .   ? -9.718  -18.320 23.038  0.65 46.12 ? 1173 HOH A O   1 
HETATM 3059 O  O   . HOH C 3 .   ? -10.783 -50.200 -12.565 1.00 40.23 ? 1174 HOH A O   1 
HETATM 3060 O  O   . HOH C 3 .   ? 1.221   -30.142 15.008  1.00 40.58 ? 1175 HOH A O   1 
HETATM 3061 O  O   . HOH C 3 .   ? -28.925 -60.009 14.997  1.00 44.53 ? 1176 HOH A O   1 
HETATM 3062 O  O   . HOH C 3 .   ? -21.385 -59.205 15.746  1.00 38.01 ? 1177 HOH A O   1 
HETATM 3063 O  O   . HOH C 3 .   ? -16.405 -6.920  13.283  1.00 54.13 ? 1178 HOH A O   1 
HETATM 3064 O  O   . HOH C 3 .   ? -6.640  -72.817 -0.099  1.00 54.04 ? 1179 HOH A O   1 
HETATM 3065 O  O   . HOH C 3 .   ? -31.850 -18.044 16.895  1.00 51.24 ? 1180 HOH A O   1 
HETATM 3066 O  O   . HOH C 3 .   ? -8.888  -56.904 -13.778 1.00 39.48 ? 1181 HOH A O   1 
HETATM 3067 O  O   . HOH C 3 .   ? -23.195 -67.443 -6.431  1.00 52.41 ? 1182 HOH A O   1 
HETATM 3068 O  O   A HOH C 3 .   ? -25.461 -30.764 5.078   0.72 23.51 ? 1183 HOH A O   1 
HETATM 3069 O  O   . HOH C 3 .   ? -15.690 -70.073 18.983  1.00 48.45 ? 1184 HOH A O   1 
HETATM 3070 O  O   . HOH C 3 .   ? -13.976 -11.810 14.866  1.00 44.53 ? 1185 HOH A O   1 
HETATM 3071 O  O   . HOH C 3 .   ? -25.308 -63.985 -4.528  1.00 50.14 ? 1186 HOH A O   1 
HETATM 3072 O  O   B HOH C 3 .   ? -12.956 -23.728 0.392   0.82 43.98 ? 1187 HOH A O   1 
HETATM 3073 O  O   A HOH C 3 .   ? -31.898 -49.941 13.265  0.97 41.68 ? 1188 HOH A O   1 
HETATM 3074 O  O   . HOH C 3 .   ? 4.697   -48.805 -1.554  1.00 45.42 ? 1189 HOH A O   1 
HETATM 3075 O  O   . HOH C 3 .   ? -14.516 -69.698 -5.968  1.00 32.90 ? 1190 HOH A O   1 
HETATM 3076 O  O   A HOH C 3 .   ? 9.005   -52.545 -5.140  0.89 27.74 ? 1191 HOH A O   1 
HETATM 3077 O  O   . HOH C 3 .   ? -13.654 -68.813 21.928  1.00 31.97 ? 1192 HOH A O   1 
HETATM 3078 O  O   . HOH C 3 .   ? -1.974  -38.219 24.776  1.00 52.80 ? 1193 HOH A O   1 
HETATM 3079 O  O   C HOH C 3 .   ? -30.256 -14.853 13.962  0.71 37.06 ? 1194 HOH A O   1 
HETATM 3080 O  O   A HOH C 3 .   ? -8.757  -21.511 6.443   1.00 30.85 ? 1195 HOH A O   1 
HETATM 3081 O  O   . HOH C 3 .   ? -2.361  -22.471 1.556   1.00 42.35 ? 1196 HOH A O   1 
HETATM 3082 O  O   . HOH C 3 .   ? -13.131 -74.877 8.695   1.00 44.78 ? 1197 HOH A O   1 
HETATM 3083 O  O   . HOH C 3 .   ? -25.823 -67.150 -0.767  1.00 55.27 ? 1198 HOH A O   1 
HETATM 3084 O  O   . HOH C 3 .   ? -7.690  -46.835 19.959  1.00 26.08 ? 1199 HOH A O   1 
HETATM 3085 O  O   . HOH C 3 .   ? -13.079 -17.052 21.241  1.00 45.87 ? 1200 HOH A O   1 
HETATM 3086 O  O   . HOH C 3 .   ? 1.562   -67.951 7.415   1.00 39.14 ? 1201 HOH A O   1 
HETATM 3087 O  O   . HOH C 3 .   ? -18.092 -60.667 17.015  1.00 51.96 ? 1202 HOH A O   1 
HETATM 3088 O  O   . HOH C 3 .   ? -3.927  -48.046 19.294  1.00 49.55 ? 1203 HOH A O   1 
HETATM 3089 O  O   . HOH C 3 .   ? -22.676 -54.740 -10.107 1.00 43.28 ? 1204 HOH A O   1 
HETATM 3090 O  O   C HOH C 3 .   ? -19.040 -58.193 16.372  0.79 30.67 ? 1205 HOH A O   1 
HETATM 3091 O  O   . HOH C 3 .   ? -0.102  -30.350 24.083  1.00 55.80 ? 1206 HOH A O   1 
HETATM 3092 O  O   A HOH C 3 .   ? -0.339  -65.085 -1.389  0.93 32.52 ? 1207 HOH A O   1 
HETATM 3093 O  O   . HOH C 3 .   ? -27.505 -14.767 23.201  1.00 53.51 ? 1208 HOH A O   1 
HETATM 3094 O  O   . HOH C 3 .   ? 2.786   -31.948 13.914  1.00 52.34 ? 1209 HOH A O   1 
HETATM 3095 O  O   A HOH C 3 .   ? -27.136 -38.960 16.241  1.00 38.98 ? 1210 HOH A O   1 
HETATM 3096 O  O   . HOH C 3 .   ? -0.564  -40.982 -2.840  1.00 24.26 ? 1211 HOH A O   1 
HETATM 3097 O  O   . HOH C 3 .   ? -31.777 -28.086 20.209  1.00 61.40 ? 1212 HOH A O   1 
HETATM 3098 O  O   . HOH C 3 .   ? -5.142  -21.761 6.003   1.00 54.33 ? 1213 HOH A O   1 
HETATM 3099 O  O   . HOH C 3 .   ? -10.451 -67.447 -5.477  1.00 29.14 ? 1214 HOH A O   1 
HETATM 3100 O  O   . HOH C 3 .   ? -26.887 -38.844 24.631  1.00 36.67 ? 1215 HOH A O   1 
HETATM 3101 O  O   . HOH C 3 .   ? -34.846 -56.875 1.004   1.00 51.43 ? 1216 HOH A O   1 
HETATM 3102 O  O   . HOH C 3 .   ? -27.124 -22.160 22.787  1.00 48.60 ? 1217 HOH A O   1 
HETATM 3103 O  O   . HOH C 3 .   ? -2.179  -61.305 -7.045  1.00 42.61 ? 1218 HOH A O   1 
HETATM 3104 O  O   A HOH C 3 .   ? -9.300  -24.030 0.893   0.94 41.00 ? 1219 HOH A O   1 
HETATM 3105 O  O   A HOH C 3 .   ? -19.448 -38.556 2.266   0.93 19.92 ? 1220 HOH A O   1 
HETATM 3106 O  O   . HOH C 3 .   ? -21.419 -47.552 20.230  1.00 50.13 ? 1221 HOH A O   1 
HETATM 3107 O  O   . HOH C 3 .   ? -30.720 -30.693 9.397   1.00 37.21 ? 1222 HOH A O   1 
HETATM 3108 O  O   . HOH C 3 .   ? -7.871  -41.479 -9.751  1.00 52.66 ? 1223 HOH A O   1 
HETATM 3109 O  O   B HOH C 3 .   ? -30.697 -50.123 14.956  0.99 46.45 ? 1224 HOH A O   1 
HETATM 3110 O  O   B HOH C 3 .   ? -4.111  -24.597 16.312  0.41 29.98 ? 1225 HOH A O   1 
HETATM 3111 O  O   . HOH C 3 .   ? -0.326  -54.212 18.209  1.00 56.99 ? 1226 HOH A O   1 
HETATM 3112 O  O   . HOH C 3 .   ? -14.531 -66.203 14.951  1.00 40.47 ? 1227 HOH A O   1 
HETATM 3113 O  O   . HOH C 3 .   ? -7.919  -56.847 18.882  1.00 53.57 ? 1228 HOH A O   1 
HETATM 3114 O  O   . HOH C 3 .   ? 0.575   -44.985 5.098   1.00 26.88 ? 1229 HOH A O   1 
HETATM 3115 O  O   . HOH C 3 .   ? 6.733   -57.760 1.560   1.00 44.23 ? 1230 HOH A O   1 
HETATM 3116 O  O   B HOH C 3 .   ? -21.100 -54.007 -15.329 1.00 53.80 ? 1231 HOH A O   1 
HETATM 3117 O  O   . HOH C 3 .   ? -27.638 -34.681 9.442   1.00 22.62 ? 1232 HOH A O   1 
HETATM 3118 O  O   . HOH C 3 .   ? -1.491  -49.117 14.644  1.00 52.49 ? 1233 HOH A O   1 
HETATM 3119 O  O   . HOH C 3 .   ? 6.388   -56.182 -2.838  1.00 40.52 ? 1234 HOH A O   1 
HETATM 3120 O  O   . HOH C 3 .   ? 7.312   -33.699 -4.742  1.00 52.61 ? 1235 HOH A O   1 
HETATM 3121 O  O   . HOH C 3 .   ? 0.320   -40.708 4.273   1.00 34.38 ? 1236 HOH A O   1 
HETATM 3122 O  O   B HOH C 3 .   ? -14.547 -49.595 -13.454 1.00 42.38 ? 1237 HOH A O   1 
HETATM 3123 O  O   B HOH C 3 .   ? -8.504  -23.118 2.451   0.90 40.79 ? 1238 HOH A O   1 
HETATM 3124 O  O   . HOH C 3 .   ? -31.439 -37.974 19.317  1.00 50.73 ? 1239 HOH A O   1 
HETATM 3125 O  O   . HOH C 3 .   ? -2.119  -51.375 16.328  1.00 47.49 ? 1240 HOH A O   1 
HETATM 3126 O  O   . HOH C 3 .   ? 6.973   -37.003 -0.421  1.00 53.91 ? 1241 HOH A O   1 
HETATM 3127 O  O   . HOH C 3 .   ? -7.896  -35.462 -4.943  1.00 23.27 ? 1242 HOH A O   1 
HETATM 3128 O  O   . HOH C 3 .   ? -2.045  -48.085 17.283  1.00 54.73 ? 1243 HOH A O   1 
HETATM 3129 O  O   . HOH C 3 .   ? 7.437   -35.491 -6.311  1.00 42.73 ? 1244 HOH A O   1 
HETATM 3130 O  O   . HOH C 3 .   ? -1.157  -68.564 4.609   1.00 39.00 ? 1245 HOH A O   1 
HETATM 3131 O  O   A HOH C 3 .   ? -7.277  -60.053 -8.198  0.98 28.22 ? 1246 HOH A O   1 
HETATM 3132 O  O   . HOH C 3 .   ? -4.514  -72.938 0.822   1.00 53.44 ? 1247 HOH A O   1 
HETATM 3133 O  O   B HOH C 3 .   ? 1.751   -60.790 -4.990  0.80 45.14 ? 1248 HOH A O   1 
HETATM 3134 O  O   . HOH C 3 .   ? -27.946 -55.716 16.723  1.00 54.93 ? 1249 HOH A O   1 
HETATM 3135 O  O   . HOH C 3 .   ? -15.705 -53.223 -15.693 1.00 33.37 ? 1250 HOH A O   1 
HETATM 3136 O  O   A HOH C 3 .   ? -9.443  -73.110 -0.830  0.67 40.46 ? 1251 HOH A O   1 
HETATM 3137 O  O   A HOH C 3 .   ? -3.925  -68.940 5.619   1.00 28.89 ? 1252 HOH A O   1 
HETATM 3138 O  O   . HOH C 3 .   ? -5.578  -46.081 18.430  1.00 27.55 ? 1253 HOH A O   1 
HETATM 3139 O  O   . HOH C 3 .   ? -21.269 -27.082 28.903  1.00 52.09 ? 1254 HOH A O   1 
HETATM 3140 O  O   . HOH C 3 .   ? 2.793   -64.356 6.102   1.00 47.12 ? 1255 HOH A O   1 
HETATM 3141 O  O   . HOH C 3 .   ? -19.680 -69.228 18.587  1.00 54.23 ? 1256 HOH A O   1 
HETATM 3142 O  O   . HOH C 3 .   ? -32.927 -35.533 12.393  0.75 41.84 ? 1257 HOH A O   1 
HETATM 3143 O  O   A HOH C 3 .   ? -0.060  -34.852 15.273  0.85 32.53 ? 1258 HOH A O   1 
HETATM 3144 O  O   . HOH C 3 .   ? -4.077  -24.718 21.321  1.00 54.37 ? 1259 HOH A O   1 
HETATM 3145 O  O   B HOH C 3 .   ? -28.694 -38.783 22.413  1.00 53.91 ? 1260 HOH A O   1 
HETATM 3146 O  O   A HOH C 3 .   ? -12.968 -48.932 -12.416 0.69 38.77 ? 1261 HOH A O   1 
HETATM 3147 O  O   . HOH C 3 .   ? -5.573  -23.592 22.945  1.00 48.36 ? 1262 HOH A O   1 
HETATM 3148 O  O   . HOH C 3 .   ? -26.131 -42.996 18.468  1.00 46.62 ? 1263 HOH A O   1 
HETATM 3149 O  O   . HOH C 3 .   ? -0.082  -54.184 15.080  1.00 53.13 ? 1264 HOH A O   1 
HETATM 3150 O  O   . HOH C 3 .   ? -25.124 -11.794 21.388  1.00 49.38 ? 1265 HOH A O   1 
HETATM 3151 O  O   . HOH C 3 .   ? -4.271  -29.047 26.658  1.00 47.80 ? 1266 HOH A O   1 
HETATM 3152 O  O   . HOH C 3 .   ? -20.471 -43.937 -10.899 1.00 21.64 ? 1267 HOH A O   1 
HETATM 3153 O  O   B HOH C 3 .   ? -23.475 -29.018 27.345  0.99 50.56 ? 1268 HOH A O   1 
HETATM 3154 O  O   . HOH C 3 .   ? -9.668  -49.678 21.541  1.00 28.69 ? 1269 HOH A O   1 
HETATM 3155 O  O   . HOH C 3 .   ? -7.111  -46.529 27.275  1.00 49.48 ? 1270 HOH A O   1 
HETATM 3156 O  O   . HOH C 3 .   ? -7.921  -54.822 -15.249 1.00 52.22 ? 1271 HOH A O   1 
HETATM 3157 O  O   . HOH C 3 .   ? -16.662 -52.362 21.695  0.57 35.81 ? 1272 HOH A O   1 
HETATM 3158 O  O   . HOH C 3 .   ? -1.620  -58.604 12.939  1.00 42.62 ? 1273 HOH A O   1 
HETATM 3159 O  O   . HOH C 3 .   ? -27.847 -66.985 5.128   1.00 41.52 ? 1274 HOH A O   1 
HETATM 3160 O  O   C HOH C 3 .   ? -25.033 -44.791 26.072  0.99 56.35 ? 1275 HOH A O   1 
HETATM 3161 O  O   B HOH C 3 .   ? -18.061 -53.088 -15.664 0.58 36.29 ? 1276 HOH A O   1 
HETATM 3162 O  O   . HOH C 3 .   ? -26.691 -41.893 25.045  1.00 59.80 ? 1277 HOH A O   1 
HETATM 3163 O  O   A HOH C 3 .   ? -7.826  -44.520 24.092  0.74 40.10 ? 1278 HOH A O   1 
HETATM 3164 O  O   . HOH C 3 .   ? -10.147 -40.584 -7.017  1.00 29.89 ? 1279 HOH A O   1 
HETATM 3165 O  O   . HOH C 3 .   ? -18.753 -22.691 29.127  1.00 56.94 ? 1280 HOH A O   1 
HETATM 3166 O  O   . HOH C 3 .   ? -30.167 -33.262 9.869   1.00 36.14 ? 1281 HOH A O   1 
HETATM 3167 O  O   A HOH C 3 .   ? -23.252 -30.795 27.530  0.84 40.78 ? 1282 HOH A O   1 
HETATM 3168 O  O   . HOH C 3 .   ? 1.500   -33.776 13.654  1.00 54.07 ? 1283 HOH A O   1 
HETATM 3169 O  O   . HOH C 3 .   ? 1.818   -66.645 5.083   1.00 33.59 ? 1284 HOH A O   1 
HETATM 3170 O  O   . HOH C 3 .   ? -27.416 -66.501 2.408   1.00 51.57 ? 1285 HOH A O   1 
HETATM 3171 O  O   . HOH C 3 .   ? -22.398 -49.442 22.289  1.00 60.85 ? 1286 HOH A O   1 
HETATM 3172 O  O   . HOH C 3 .   ? -28.154 -12.705 18.706  1.00 43.06 ? 1287 HOH A O   1 
HETATM 3173 O  O   A HOH C 3 .   ? -15.761 -57.749 19.124  1.00 50.73 ? 1288 HOH A O   1 
HETATM 3174 O  O   . HOH C 3 .   ? -35.280 -60.747 3.439   1.00 51.23 ? 1289 HOH A O   1 
HETATM 3175 O  O   . HOH C 3 .   ? -32.682 -29.940 11.711  1.00 54.34 ? 1290 HOH A O   1 
HETATM 3176 O  O   . HOH C 3 .   ? -17.473 -69.597 -8.883  1.00 54.70 ? 1291 HOH A O   1 
HETATM 3177 O  O   . HOH C 3 .   ? -29.557 -18.829 21.340  1.00 50.65 ? 1292 HOH A O   1 
HETATM 3178 O  O   . HOH C 3 .   ? 2.462   -46.450 3.608   1.00 43.60 ? 1293 HOH A O   1 
HETATM 3179 O  O   . HOH C 3 .   ? 1.314   -32.461 16.506  1.00 58.19 ? 1294 HOH A O   1 
HETATM 3180 O  O   . HOH C 3 .   ? -33.813 -56.548 13.577  1.00 56.20 ? 1295 HOH A O   1 
HETATM 3181 O  O   . HOH C 3 .   ? -2.751  -71.550 2.070   1.00 43.06 ? 1296 HOH A O   1 
HETATM 3182 O  O   . HOH C 3 .   ? -20.205 -46.606 -15.454 1.00 53.31 ? 1297 HOH A O   1 
HETATM 3183 O  O   . HOH C 3 .   ? -16.602 -28.755 30.788  0.50 48.84 ? 1298 HOH A O   1 
HETATM 3184 O  O   . HOH C 3 .   ? -25.088 -26.896 4.488   1.00 21.36 ? 1299 HOH A O   1 
HETATM 3185 O  O   . HOH C 3 .   ? 1.079   -59.680 8.530   1.00 47.84 ? 1300 HOH A O   1 
HETATM 3186 O  O   A HOH C 3 .   ? -27.213 -39.776 20.810  1.00 46.26 ? 1301 HOH A O   1 
HETATM 3187 O  O   A HOH C 3 .   ? 2.074   -49.572 11.860  0.60 27.71 ? 1302 HOH A O   1 
HETATM 3188 O  O   . HOH C 3 .   ? -20.808 -54.871 -11.335 1.00 39.69 ? 1303 HOH A O   1 
HETATM 3189 O  O   A HOH C 3 .   ? -9.531  -30.000 27.355  1.00 45.26 ? 1304 HOH A O   1 
HETATM 3190 O  O   . HOH C 3 .   ? -6.300  -53.013 20.731  1.00 48.18 ? 1305 HOH A O   1 
HETATM 3191 O  O   . HOH C 3 .   ? -18.628 -32.264 0.000   0.50 35.90 ? 1306 HOH A O   1 
HETATM 3192 O  O   . HOH C 3 .   ? -33.859 -34.291 15.057  1.00 47.17 ? 1307 HOH A O   1 
HETATM 3193 O  O   . HOH C 3 .   ? -30.093 -38.376 27.425  1.00 58.45 ? 1308 HOH A O   1 
HETATM 3194 O  O   . HOH C 3 .   ? -12.207 -68.329 -13.218 1.00 52.89 ? 1309 HOH A O   1 
HETATM 3195 O  O   . HOH C 3 .   ? -26.620 -46.106 0.000   0.50 17.36 ? 1310 HOH A O   1 
HETATM 3196 O  O   . HOH C 3 .   ? -16.134 -61.768 15.806  1.00 30.36 ? 1311 HOH A O   1 
HETATM 3197 O  O   . HOH C 3 .   ? 0.383   -67.384 -3.075  1.00 48.44 ? 1312 HOH A O   1 
HETATM 3198 O  O   . HOH C 3 .   ? 5.271   -55.426 10.858  1.00 47.32 ? 1313 HOH A O   1 
HETATM 3199 O  O   . HOH C 3 .   ? -29.686 -64.017 0.108   1.00 31.96 ? 1314 HOH A O   1 
HETATM 3200 O  O   . HOH C 3 .   ? 3.379   -58.641 8.333   1.00 38.01 ? 1315 HOH A O   1 
HETATM 3201 O  O   . HOH C 3 .   ? -18.609 -26.706 31.395  1.00 47.14 ? 1316 HOH A O   1 
HETATM 3202 O  O   . HOH C 3 .   ? -7.721  -76.905 8.611   1.00 43.70 ? 1317 HOH A O   1 
HETATM 3203 O  O   . HOH C 3 .   ? -31.970 -36.261 21.062  1.00 52.25 ? 1318 HOH A O   1 
HETATM 3204 O  O   A HOH C 3 .   ? -21.279 -29.434 28.269  0.70 33.40 ? 1319 HOH A O   1 
HETATM 3205 O  O   C HOH C 3 .   ? -23.960 -57.186 -11.396 1.00 53.44 ? 1320 HOH A O   1 
HETATM 3206 O  O   . HOH C 3 .   ? -12.919 -52.141 23.492  1.00 44.36 ? 1321 HOH A O   1 
HETATM 3207 O  O   . HOH C 3 .   ? -26.690 -69.613 6.308   1.00 49.78 ? 1322 HOH A O   1 
HETATM 3208 O  O   . HOH C 3 .   ? -34.956 -56.286 11.666  1.00 55.37 ? 1323 HOH A O   1 
HETATM 3209 O  O   B HOH C 3 .   ? 0.904   -49.854 13.162  0.63 31.95 ? 1324 HOH A O   1 
HETATM 3210 O  O   . HOH C 3 .   ? 7.460   -27.427 -3.593  1.00 51.19 ? 1325 HOH A O   1 
HETATM 3211 O  O   . HOH C 3 .   ? -23.688 -47.097 20.663  1.00 54.88 ? 1326 HOH A O   1 
HETATM 3212 O  O   . HOH C 3 .   ? -7.309  -57.502 -9.467  1.00 29.88 ? 1327 HOH A O   1 
HETATM 3213 O  O   . HOH C 3 .   ? -23.720 -45.163 -14.375 1.00 31.94 ? 1328 HOH A O   1 
HETATM 3214 O  O   . HOH C 3 .   ? -4.991  -43.792 19.988  1.00 40.52 ? 1329 HOH A O   1 
HETATM 3215 O  O   . HOH C 3 .   ? -25.348 -45.116 20.450  1.00 57.79 ? 1330 HOH A O   1 
HETATM 3216 O  O   . HOH C 3 .   ? -29.776 -14.794 18.524  1.00 46.56 ? 1331 HOH A O   1 
HETATM 3217 O  O   B HOH C 3 .   ? -7.267  -21.207 5.567   1.00 53.26 ? 1332 HOH A O   1 
HETATM 3218 O  O   . HOH C 3 .   ? 0.318   -68.555 0.521   1.00 34.16 ? 1333 HOH A O   1 
HETATM 3219 O  O   C HOH C 3 .   ? -13.868 -56.953 18.057  0.53 30.12 ? 1334 HOH A O   1 
HETATM 3220 O  O   . HOH C 3 .   ? -12.804 -69.604 -8.541  1.00 40.52 ? 1335 HOH A O   1 
HETATM 3221 O  O   . HOH C 3 .   ? -12.322 -46.263 -10.559 1.00 39.19 ? 1336 HOH A O   1 
HETATM 3222 O  O   . HOH C 3 .   ? 4.299   -53.500 11.419  1.00 50.18 ? 1337 HOH A O   1 
HETATM 3223 O  O   A HOH C 3 .   ? -18.414 -52.106 -13.196 1.00 39.39 ? 1338 HOH A O   1 
HETATM 3224 O  O   . HOH C 3 .   ? -14.739 -69.729 -10.481 1.00 41.10 ? 1339 HOH A O   1 
HETATM 3225 O  O   . HOH C 3 .   ? -25.631 -44.219 16.339  1.00 22.73 ? 1340 HOH A O   1 
HETATM 3226 O  O   . HOH C 3 .   ? -14.693 -53.389 22.480  0.55 38.65 ? 1341 HOH A O   1 
HETATM 3227 O  O   . HOH C 3 .   ? -7.060  -44.199 21.090  1.00 37.40 ? 1342 HOH A O   1 
HETATM 3228 O  O   . HOH C 3 .   ? -31.415 -62.220 0.059   1.00 44.21 ? 1343 HOH A O   1 
HETATM 3229 O  O   . HOH C 3 .   ? -19.744 -34.197 0.000   0.50 29.13 ? 1344 HOH A O   1 
HETATM 3230 O  O   . HOH C 3 .   ? -6.847  -21.172 21.715  1.00 40.13 ? 1345 HOH A O   1 
HETATM 3231 O  O   . HOH C 3 .   ? -8.756  -48.592 23.746  1.00 44.43 ? 1346 HOH A O   1 
HETATM 3232 O  O   . HOH C 3 .   ? -6.411  -48.058 21.992  1.00 48.46 ? 1347 HOH A O   1 
HETATM 3233 O  O   . HOH C 3 .   ? -26.654 -46.670 16.955  1.00 40.11 ? 1348 HOH A O   1 
HETATM 3234 O  O   . HOH C 3 .   ? 2.645   -68.129 1.138   1.00 55.53 ? 1349 HOH A O   1 
HETATM 3235 O  O   . HOH C 3 .   ? -0.430  -70.580 1.778   1.00 54.27 ? 1350 HOH A O   1 
HETATM 3236 O  O   . HOH C 3 .   ? -11.175 -54.520 22.378  1.00 50.97 ? 1351 HOH A O   1 
HETATM 3237 O  O   B HOH C 3 .   ? -20.275 -52.692 -12.999 0.73 31.47 ? 1352 HOH A O   1 
HETATM 3238 O  O   . HOH C 3 .   ? -30.262 -60.739 -2.539  1.00 47.78 ? 1353 HOH A O   1 
HETATM 3239 O  O   . HOH C 3 .   ? -8.032  -17.264 21.787  1.00 50.95 ? 1354 HOH A O   1 
HETATM 3240 O  O   . HOH C 3 .   ? 3.355   -53.863 13.470  1.00 52.83 ? 1355 HOH A O   1 
HETATM 3241 O  O   . HOH C 3 .   ? -30.664 -62.732 15.811  1.00 50.93 ? 1356 HOH A O   1 
HETATM 3242 O  O   . HOH C 3 .   ? -7.055  -60.534 -17.123 1.00 61.85 ? 1357 HOH A O   1 
HETATM 3243 O  O   . HOH C 3 .   ? 2.432   -55.953 15.289  1.00 52.87 ? 1358 HOH A O   1 
HETATM 3244 O  O   . HOH C 3 .   ? 0.708   -69.345 -1.991  1.00 50.46 ? 1359 HOH A O   1 
HETATM 3245 O  O   . HOH C 3 .   ? -34.867 -34.351 18.230  1.00 52.68 ? 1360 HOH A O   1 
HETATM 3246 O  O   . HOH C 3 .   ? -16.325 -63.900 19.217  1.00 56.27 ? 1361 HOH A O   1 
HETATM 3247 O  O   . HOH C 3 .   ? 4.986   -50.207 12.618  1.00 54.19 ? 1362 HOH A O   1 
HETATM 3248 O  O   . HOH C 3 .   ? -29.158 -42.540 18.154  1.00 51.60 ? 1363 HOH A O   1 
HETATM 3249 O  O   . HOH C 3 .   ? -6.372  -54.177 23.603  1.00 52.15 ? 1364 HOH A O   1 
HETATM 3250 O  O   . HOH C 3 .   ? 4.570   -56.601 13.411  1.00 52.47 ? 1365 HOH A O   1 
# 
