data_9E70
# 
_entry.id   9E70 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9E70         pdb_00009e70 10.2210/pdb9e70/pdb 
WWPDB D_1000281345 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-09 ? 
2 'Structure model' 1 1 2025-04-23 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9E70 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              aboriacksjodin@accenttx.com 
_pdbx_contact_author.name_first         Ann 
_pdbx_contact_author.name_last          Boriack-Sjodin 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0179-5936 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lockbaum, G.J.'       1 0000-0003-2720-6984 
'Lynes, M.M.'          2 0000-0001-6808-5109 
'Sickmier, E.A.'       3 0000-0002-5595-9257 
'Grigoriu, S.'         4 0000-0002-5525-7300 
'Boriack-Sjodin, P.A.' 5 0000-0003-0179-5936 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Commun Biol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2399-3642 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            8 
_citation.language                  ? 
_citation.page_first                589 
_citation.page_last                 589 
_citation.title                     
;Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s42003-025-08005-y 
_citation.pdbx_database_id_PubMed   40205031 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lockbaum, G.J.'       1  0000-0003-2720-6984 
primary 'Lynes, M.M.'          2  0000-0001-6808-5109 
primary 'Shen, S.A.'           3  ?                   
primary 'Liu, J.'              4  ?                   
primary 'Holt, N.'             5  ?                   
primary 'Nayak, S.P.'          6  ?                   
primary 'Knockenhauer, K.E.'   7  ?                   
primary 'Yao, S.'              8  ?                   
primary 'Sickmier, E.A.'       9  ?                   
primary 'Raman, A.'            10 ?                   
primary 'Wu, J.'               11 0000-0002-0989-8115 
primary 'Case, A.'             12 ?                   
primary 'Shehaj, L.'           13 ?                   
primary 'Buker, S.M.'          14 ?                   
primary 'Grigoriu, S.'         15 ?                   
primary 'Ribich, S.'           16 ?                   
primary 'Blakemore, S.J.'      17 ?                   
primary 'Sparling, B.A.'       18 0000-0001-5184-0956 
primary 'Duncan, K.W.'         19 0000-0002-3047-7825 
primary 'Copeland, R.A.'       20 0000-0002-1897-6533 
primary 'Silver, S.J.'         21 0000-0001-8090-2941 
primary 'Boriack-Sjodin, P.A.' 22 0000-0003-0179-5936 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;5'-3' exoribonuclease 1
;
78101.648 2   3.1.13.- ? ? ? 
2 non-polymer syn "ADENOSINE-3'-5'-DIPHOSPHATE" 427.201   1   ?        ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'               24.305    2   ?        ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                62.068    16  ?        ? ? ? 
5 non-polymer syn 'CHLORIDE ION'                35.453    1   ?        ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'       106.120   1   ?        ? ? ? 
7 water       nat water                         18.015    723 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Strand-exchange protein 1 homolog' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKV
FFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKS
WQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPE
LGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWT
ALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEW
EAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVD
INKNKITRIDQKADYKDDDDK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKV
FFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKS
WQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPE
LGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWT
ALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEW
EAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVD
INKNKITRIDQKADYKDDDDK
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "ADENOSINE-3'-5'-DIPHOSPHATE" A3P 
3 'MAGNESIUM ION'               MG  
4 1,2-ETHANEDIOL                EDO 
5 'CHLORIDE ION'                CL  
6 'DI(HYDROXYETHYL)ETHER'       PEG 
7 water                         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   VAL n 
1 4   PRO n 
1 5   LYS n 
1 6   PHE n 
1 7   TYR n 
1 8   ARG n 
1 9   TRP n 
1 10  ILE n 
1 11  SER n 
1 12  GLU n 
1 13  ARG n 
1 14  TYR n 
1 15  PRO n 
1 16  CYS n 
1 17  LEU n 
1 18  SER n 
1 19  GLU n 
1 20  VAL n 
1 21  VAL n 
1 22  LYS n 
1 23  GLU n 
1 24  HIS n 
1 25  GLN n 
1 26  ILE n 
1 27  PRO n 
1 28  GLU n 
1 29  PHE n 
1 30  ASP n 
1 31  ASN n 
1 32  LEU n 
1 33  TYR n 
1 34  LEU n 
1 35  ASP n 
1 36  MET n 
1 37  ASN n 
1 38  GLY n 
1 39  ILE n 
1 40  ILE n 
1 41  HIS n 
1 42  GLN n 
1 43  CYS n 
1 44  SER n 
1 45  HIS n 
1 46  PRO n 
1 47  ASN n 
1 48  ASP n 
1 49  ASP n 
1 50  ASP n 
1 51  VAL n 
1 52  HIS n 
1 53  PHE n 
1 54  ARG n 
1 55  ILE n 
1 56  SER n 
1 57  ASP n 
1 58  ASP n 
1 59  LYS n 
1 60  ILE n 
1 61  PHE n 
1 62  THR n 
1 63  ASP n 
1 64  ILE n 
1 65  PHE n 
1 66  HIS n 
1 67  TYR n 
1 68  LEU n 
1 69  GLU n 
1 70  VAL n 
1 71  LEU n 
1 72  PHE n 
1 73  ARG n 
1 74  ILE n 
1 75  ILE n 
1 76  LYS n 
1 77  PRO n 
1 78  ARG n 
1 79  LYS n 
1 80  VAL n 
1 81  PHE n 
1 82  PHE n 
1 83  MET n 
1 84  ALA n 
1 85  VAL n 
1 86  ASP n 
1 87  GLY n 
1 88  VAL n 
1 89  ALA n 
1 90  PRO n 
1 91  ARG n 
1 92  ALA n 
1 93  LYS n 
1 94  MET n 
1 95  ASN n 
1 96  GLN n 
1 97  GLN n 
1 98  ARG n 
1 99  GLY n 
1 100 ARG n 
1 101 ARG n 
1 102 PHE n 
1 103 ARG n 
1 104 SER n 
1 105 ALA n 
1 106 LYS n 
1 107 GLU n 
1 108 ALA n 
1 109 GLU n 
1 110 ASP n 
1 111 LYS n 
1 112 ILE n 
1 113 LYS n 
1 114 LYS n 
1 115 ALA n 
1 116 ILE n 
1 117 GLU n 
1 118 LYS n 
1 119 GLY n 
1 120 GLU n 
1 121 THR n 
1 122 LEU n 
1 123 PRO n 
1 124 THR n 
1 125 GLU n 
1 126 ALA n 
1 127 ARG n 
1 128 PHE n 
1 129 ASP n 
1 130 SER n 
1 131 ASN n 
1 132 CYS n 
1 133 ILE n 
1 134 THR n 
1 135 PRO n 
1 136 GLY n 
1 137 THR n 
1 138 GLU n 
1 139 PHE n 
1 140 MET n 
1 141 ALA n 
1 142 ARG n 
1 143 LEU n 
1 144 HIS n 
1 145 GLU n 
1 146 HIS n 
1 147 LEU n 
1 148 LYS n 
1 149 TYR n 
1 150 PHE n 
1 151 VAL n 
1 152 ASN n 
1 153 MET n 
1 154 LYS n 
1 155 ILE n 
1 156 SER n 
1 157 THR n 
1 158 ASP n 
1 159 LYS n 
1 160 SER n 
1 161 TRP n 
1 162 GLN n 
1 163 GLY n 
1 164 VAL n 
1 165 THR n 
1 166 ILE n 
1 167 TYR n 
1 168 PHE n 
1 169 SER n 
1 170 GLY n 
1 171 HIS n 
1 172 GLU n 
1 173 THR n 
1 174 PRO n 
1 175 GLY n 
1 176 GLU n 
1 177 GLY n 
1 178 GLU n 
1 179 HIS n 
1 180 LYS n 
1 181 ILE n 
1 182 MET n 
1 183 GLU n 
1 184 PHE n 
1 185 ILE n 
1 186 ARG n 
1 187 SER n 
1 188 GLU n 
1 189 LYS n 
1 190 ALA n 
1 191 LYS n 
1 192 PRO n 
1 193 ASP n 
1 194 HIS n 
1 195 ASP n 
1 196 PRO n 
1 197 ASN n 
1 198 THR n 
1 199 ARG n 
1 200 HIS n 
1 201 CYS n 
1 202 LEU n 
1 203 TYR n 
1 204 GLY n 
1 205 LEU n 
1 206 ASP n 
1 207 ALA n 
1 208 ASP n 
1 209 LEU n 
1 210 ILE n 
1 211 MET n 
1 212 LEU n 
1 213 GLY n 
1 214 LEU n 
1 215 THR n 
1 216 SER n 
1 217 HIS n 
1 218 GLU n 
1 219 ALA n 
1 220 HIS n 
1 221 PHE n 
1 222 SER n 
1 223 LEU n 
1 224 LEU n 
1 225 ARG n 
1 226 GLU n 
1 227 GLU n 
1 228 VAL n 
1 229 ARG n 
1 230 PHE n 
1 231 GLY n 
1 232 GLY n 
1 233 LYS n 
1 234 LYS n 
1 235 THR n 
1 236 GLN n 
1 237 ARG n 
1 238 VAL n 
1 239 CYS n 
1 240 ALA n 
1 241 PRO n 
1 242 GLU n 
1 243 GLU n 
1 244 THR n 
1 245 THR n 
1 246 PHE n 
1 247 HIS n 
1 248 LEU n 
1 249 LEU n 
1 250 HIS n 
1 251 LEU n 
1 252 SER n 
1 253 LEU n 
1 254 MET n 
1 255 ARG n 
1 256 GLU n 
1 257 TYR n 
1 258 ILE n 
1 259 ASP n 
1 260 TYR n 
1 261 GLU n 
1 262 PHE n 
1 263 SER n 
1 264 VAL n 
1 265 LEU n 
1 266 LYS n 
1 267 GLU n 
1 268 LYS n 
1 269 ILE n 
1 270 THR n 
1 271 PHE n 
1 272 LYS n 
1 273 TYR n 
1 274 ASP n 
1 275 ILE n 
1 276 GLU n 
1 277 ARG n 
1 278 ILE n 
1 279 ILE n 
1 280 ASP n 
1 281 ASP n 
1 282 TRP n 
1 283 ILE n 
1 284 LEU n 
1 285 MET n 
1 286 GLY n 
1 287 PHE n 
1 288 LEU n 
1 289 VAL n 
1 290 GLY n 
1 291 ASN n 
1 292 ASP n 
1 293 PHE n 
1 294 ILE n 
1 295 PRO n 
1 296 HIS n 
1 297 LEU n 
1 298 PRO n 
1 299 HIS n 
1 300 LEU n 
1 301 HIS n 
1 302 ILE n 
1 303 ASN n 
1 304 HIS n 
1 305 ASP n 
1 306 ALA n 
1 307 LEU n 
1 308 PRO n 
1 309 LEU n 
1 310 LEU n 
1 311 TYR n 
1 312 GLY n 
1 313 THR n 
1 314 TYR n 
1 315 VAL n 
1 316 THR n 
1 317 ILE n 
1 318 LEU n 
1 319 PRO n 
1 320 GLU n 
1 321 LEU n 
1 322 GLY n 
1 323 GLY n 
1 324 TYR n 
1 325 ILE n 
1 326 ASN n 
1 327 GLU n 
1 328 SER n 
1 329 GLY n 
1 330 HIS n 
1 331 LEU n 
1 332 ASN n 
1 333 LEU n 
1 334 PRO n 
1 335 ARG n 
1 336 PHE n 
1 337 GLU n 
1 338 LYS n 
1 339 TYR n 
1 340 LEU n 
1 341 VAL n 
1 342 LYS n 
1 343 LEU n 
1 344 SER n 
1 345 ASP n 
1 346 PHE n 
1 347 ASP n 
1 348 ARG n 
1 349 GLU n 
1 350 HIS n 
1 351 PHE n 
1 352 SER n 
1 353 GLU n 
1 354 VAL n 
1 355 PHE n 
1 356 VAL n 
1 357 ASP n 
1 358 LEU n 
1 359 LYS n 
1 360 TRP n 
1 361 PHE n 
1 362 GLU n 
1 363 SER n 
1 364 LYS n 
1 365 VAL n 
1 366 GLY n 
1 367 ASN n 
1 368 LYS n 
1 369 TYR n 
1 370 LEU n 
1 371 ASN n 
1 372 GLU n 
1 373 ALA n 
1 374 ALA n 
1 375 GLY n 
1 376 VAL n 
1 377 ALA n 
1 378 ALA n 
1 379 GLU n 
1 380 GLU n 
1 381 ALA n 
1 382 ARG n 
1 383 ASN n 
1 384 TYR n 
1 385 LYS n 
1 386 GLU n 
1 387 LYS n 
1 388 LYS n 
1 389 LYS n 
1 390 LEU n 
1 391 LYS n 
1 392 GLY n 
1 393 GLN n 
1 394 GLU n 
1 395 ASN n 
1 396 SER n 
1 397 LEU n 
1 398 CYS n 
1 399 TRP n 
1 400 THR n 
1 401 ALA n 
1 402 LEU n 
1 403 ASP n 
1 404 LYS n 
1 405 ASN n 
1 406 GLU n 
1 407 GLY n 
1 408 GLU n 
1 409 MET n 
1 410 ILE n 
1 411 THR n 
1 412 SER n 
1 413 LYS n 
1 414 ASP n 
1 415 ASN n 
1 416 LEU n 
1 417 GLU n 
1 418 ASP n 
1 419 GLU n 
1 420 THR n 
1 421 GLU n 
1 422 ASP n 
1 423 ASP n 
1 424 ASP n 
1 425 LEU n 
1 426 PHE n 
1 427 GLU n 
1 428 THR n 
1 429 GLU n 
1 430 PHE n 
1 431 ARG n 
1 432 GLN n 
1 433 TYR n 
1 434 LYS n 
1 435 ARG n 
1 436 THR n 
1 437 TYR n 
1 438 TYR n 
1 439 MET n 
1 440 THR n 
1 441 LYS n 
1 442 MET n 
1 443 GLY n 
1 444 VAL n 
1 445 ASP n 
1 446 VAL n 
1 447 VAL n 
1 448 SER n 
1 449 ASP n 
1 450 ASP n 
1 451 PHE n 
1 452 LEU n 
1 453 ALA n 
1 454 ASP n 
1 455 GLN n 
1 456 ALA n 
1 457 ALA n 
1 458 CYS n 
1 459 TYR n 
1 460 VAL n 
1 461 GLN n 
1 462 ALA n 
1 463 ILE n 
1 464 GLN n 
1 465 TRP n 
1 466 ILE n 
1 467 LEU n 
1 468 HIS n 
1 469 TYR n 
1 470 TYR n 
1 471 TYR n 
1 472 HIS n 
1 473 GLY n 
1 474 VAL n 
1 475 GLN n 
1 476 SER n 
1 477 TRP n 
1 478 SER n 
1 479 TRP n 
1 480 TYR n 
1 481 TYR n 
1 482 PRO n 
1 483 TYR n 
1 484 HIS n 
1 485 TYR n 
1 486 ALA n 
1 487 PRO n 
1 488 PHE n 
1 489 LEU n 
1 490 SER n 
1 491 ASP n 
1 492 ILE n 
1 493 HIS n 
1 494 ASN n 
1 495 ILE n 
1 496 SER n 
1 497 THR n 
1 498 LEU n 
1 499 LYS n 
1 500 ILE n 
1 501 HIS n 
1 502 PHE n 
1 503 GLU n 
1 504 LEU n 
1 505 GLY n 
1 506 LYS n 
1 507 PRO n 
1 508 PHE n 
1 509 LYS n 
1 510 PRO n 
1 511 PHE n 
1 512 GLU n 
1 513 GLN n 
1 514 LEU n 
1 515 LEU n 
1 516 ALA n 
1 517 VAL n 
1 518 LEU n 
1 519 PRO n 
1 520 ALA n 
1 521 ALA n 
1 522 SER n 
1 523 LYS n 
1 524 ASN n 
1 525 LEU n 
1 526 LEU n 
1 527 PRO n 
1 528 ALA n 
1 529 CYS n 
1 530 TYR n 
1 531 GLN n 
1 532 HIS n 
1 533 LEU n 
1 534 MET n 
1 535 THR n 
1 536 ASN n 
1 537 GLU n 
1 538 ASP n 
1 539 SER n 
1 540 PRO n 
1 541 ILE n 
1 542 ILE n 
1 543 GLU n 
1 544 TYR n 
1 545 TYR n 
1 546 PRO n 
1 547 PRO n 
1 548 ASP n 
1 549 PHE n 
1 550 LYS n 
1 551 THR n 
1 552 ASP n 
1 553 LEU n 
1 554 ASN n 
1 555 GLY n 
1 556 LYS n 
1 557 GLN n 
1 558 GLN n 
1 559 GLU n 
1 560 TRP n 
1 561 GLU n 
1 562 ALA n 
1 563 VAL n 
1 564 VAL n 
1 565 LEU n 
1 566 ILE n 
1 567 PRO n 
1 568 PHE n 
1 569 ILE n 
1 570 ASP n 
1 571 GLU n 
1 572 LYS n 
1 573 ARG n 
1 574 LEU n 
1 575 LEU n 
1 576 GLU n 
1 577 ALA n 
1 578 MET n 
1 579 GLU n 
1 580 THR n 
1 581 CYS n 
1 582 ASN n 
1 583 HIS n 
1 584 SER n 
1 585 LEU n 
1 586 LYS n 
1 587 LYS n 
1 588 GLU n 
1 589 GLU n 
1 590 ARG n 
1 591 LYS n 
1 592 ARG n 
1 593 ASN n 
1 594 GLN n 
1 595 HIS n 
1 596 SER n 
1 597 GLU n 
1 598 CYS n 
1 599 LEU n 
1 600 MET n 
1 601 CYS n 
1 602 TRP n 
1 603 TYR n 
1 604 ASP n 
1 605 ARG n 
1 606 ASP n 
1 607 THR n 
1 608 GLU n 
1 609 PHE n 
1 610 ILE n 
1 611 TYR n 
1 612 PRO n 
1 613 SER n 
1 614 PRO n 
1 615 TRP n 
1 616 PRO n 
1 617 GLU n 
1 618 LYS n 
1 619 PHE n 
1 620 PRO n 
1 621 ALA n 
1 622 ILE n 
1 623 GLU n 
1 624 ARG n 
1 625 CYS n 
1 626 CYS n 
1 627 THR n 
1 628 ARG n 
1 629 TYR n 
1 630 LYS n 
1 631 ILE n 
1 632 ILE n 
1 633 SER n 
1 634 LEU n 
1 635 ASP n 
1 636 ALA n 
1 637 TRP n 
1 638 ARG n 
1 639 VAL n 
1 640 ASP n 
1 641 ILE n 
1 642 ASN n 
1 643 LYS n 
1 644 ASN n 
1 645 LYS n 
1 646 ILE n 
1 647 THR n 
1 648 ARG n 
1 649 ILE n 
1 650 ASP n 
1 651 GLN n 
1 652 LYS n 
1 653 ALA n 
1 654 ASP n 
1 655 TYR n 
1 656 LYS n 
1 657 ASP n 
1 658 ASP n 
1 659 ASP n 
1 660 ASP n 
1 661 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   661 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'XRN1, SEP1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 Expi293F 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A3P 'RNA linking'       n "ADENOSINE-3'-5'-DIPHOSPHATE" ?                 'C10 H15 N5 O10 P2' 427.201 
ALA 'L-peptide linking' y ALANINE                       ?                 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                      ?                 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                    ?                 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'               ?                 'C4 H7 N O4'        133.103 
CL  non-polymer         . 'CHLORIDE ION'                ?                 'Cl -1'             35.453  
CYS 'L-peptide linking' y CYSTEINE                      ?                 'C3 H7 N O2 S'      121.158 
EDO non-polymer         . 1,2-ETHANEDIOL                'ETHYLENE GLYCOL' 'C2 H6 O2'          62.068  
GLN 'L-peptide linking' y GLUTAMINE                     ?                 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'               ?                 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                       ?                 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                     ?                 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                         ?                 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                    ?                 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                       ?                 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                        ?                 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                    ?                 'C5 H11 N O2 S'     149.211 
MG  non-polymer         . 'MAGNESIUM ION'               ?                 'Mg 2'              24.305  
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'       ?                 'C4 H10 O3'         106.120 
PHE 'L-peptide linking' y PHENYLALANINE                 ?                 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                       ?                 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                        ?                 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                     ?                 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                    ?                 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                      ?                 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                        ?                 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   VAL 3   3   3   VAL VAL A . n 
A 1 4   PRO 4   4   4   PRO PRO A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   PHE 6   6   6   PHE PHE A . n 
A 1 7   TYR 7   7   7   TYR TYR A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   TRP 9   9   9   TRP TRP A . n 
A 1 10  ILE 10  10  10  ILE ILE A . n 
A 1 11  SER 11  11  11  SER SER A . n 
A 1 12  GLU 12  12  12  GLU GLU A . n 
A 1 13  ARG 13  13  13  ARG ARG A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  PRO 15  15  15  PRO PRO A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  VAL 21  21  21  VAL VAL A . n 
A 1 22  LYS 22  22  22  LYS LYS A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  HIS 24  24  24  HIS HIS A . n 
A 1 25  GLN 25  25  25  GLN GLN A . n 
A 1 26  ILE 26  26  26  ILE ILE A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  GLU 28  28  28  GLU GLU A . n 
A 1 29  PHE 29  29  29  PHE PHE A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  ASN 31  31  31  ASN ASN A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  TYR 33  33  33  TYR TYR A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  ASN 37  37  37  ASN ASN A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  ILE 39  39  39  ILE ILE A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  GLN 42  42  42  GLN GLN A . n 
A 1 43  CYS 43  43  43  CYS CYS A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  HIS 45  45  45  HIS HIS A . n 
A 1 46  PRO 46  46  46  PRO PRO A . n 
A 1 47  ASN 47  47  47  ASN ASN A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  ASP 49  49  49  ASP ASP A . n 
A 1 50  ASP 50  50  50  ASP ASP A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  HIS 52  52  52  HIS HIS A . n 
A 1 53  PHE 53  53  53  PHE PHE A . n 
A 1 54  ARG 54  54  54  ARG ARG A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  ASP 57  57  57  ASP ASP A . n 
A 1 58  ASP 58  58  58  ASP ASP A . n 
A 1 59  LYS 59  59  59  LYS LYS A . n 
A 1 60  ILE 60  60  60  ILE ILE A . n 
A 1 61  PHE 61  61  61  PHE PHE A . n 
A 1 62  THR 62  62  62  THR THR A . n 
A 1 63  ASP 63  63  63  ASP ASP A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  HIS 66  66  66  HIS HIS A . n 
A 1 67  TYR 67  67  67  TYR TYR A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  VAL 70  70  70  VAL VAL A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  PHE 72  72  72  PHE PHE A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  ILE 75  75  75  ILE ILE A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  PRO 77  77  77  PRO PRO A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  LYS 79  79  79  LYS LYS A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  ASP 86  86  86  ASP ASP A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  ALA 89  89  89  ALA ALA A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  ARG 91  91  91  ARG ARG A . n 
A 1 92  ALA 92  92  92  ALA ALA A . n 
A 1 93  LYS 93  93  93  LYS LYS A . n 
A 1 94  MET 94  94  94  MET MET A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  GLN 96  96  96  GLN GLN A . n 
A 1 97  GLN 97  97  97  GLN GLN A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 ARG 101 101 101 ARG ARG A . n 
A 1 102 PHE 102 102 102 PHE PHE A . n 
A 1 103 ARG 103 103 103 ARG ARG A . n 
A 1 104 SER 104 104 104 SER SER A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 GLU 107 107 107 GLU GLU A . n 
A 1 108 ALA 108 108 108 ALA ALA A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 ILE 112 112 112 ILE ILE A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 GLY 119 119 119 GLY GLY A . n 
A 1 120 GLU 120 120 120 GLU GLU A . n 
A 1 121 THR 121 121 121 THR THR A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 ARG 127 127 127 ARG ARG A . n 
A 1 128 PHE 128 128 128 PHE PHE A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 SER 130 130 130 SER SER A . n 
A 1 131 ASN 131 131 131 ASN ASN A . n 
A 1 132 CYS 132 132 132 CYS CYS A . n 
A 1 133 ILE 133 133 133 ILE ILE A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 THR 137 137 137 THR THR A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 MET 140 140 140 MET MET A . n 
A 1 141 ALA 141 141 141 ALA ALA A . n 
A 1 142 ARG 142 142 142 ARG ARG A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 HIS 144 144 144 HIS HIS A . n 
A 1 145 GLU 145 145 145 GLU GLU A . n 
A 1 146 HIS 146 146 146 HIS HIS A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 MET 153 153 153 MET MET A . n 
A 1 154 LYS 154 154 154 LYS LYS A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 THR 157 157 157 THR THR A . n 
A 1 158 ASP 158 158 158 ASP ASP A . n 
A 1 159 LYS 159 159 159 LYS LYS A . n 
A 1 160 SER 160 160 160 SER SER A . n 
A 1 161 TRP 161 161 161 TRP TRP A . n 
A 1 162 GLN 162 162 162 GLN GLN A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 THR 165 165 165 THR THR A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 TYR 167 167 167 TYR TYR A . n 
A 1 168 PHE 168 168 168 PHE PHE A . n 
A 1 169 SER 169 169 169 SER SER A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 HIS 171 171 171 HIS HIS A . n 
A 1 172 GLU 172 172 172 GLU GLU A . n 
A 1 173 THR 173 173 173 THR THR A . n 
A 1 174 PRO 174 174 174 PRO PRO A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 GLU 176 176 176 GLU GLU A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 HIS 179 179 179 HIS HIS A . n 
A 1 180 LYS 180 180 180 LYS LYS A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 MET 182 182 182 MET MET A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 ILE 185 185 185 ILE ILE A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 GLU 188 188 188 GLU GLU A . n 
A 1 189 LYS 189 189 189 LYS LYS A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 PRO 192 192 192 PRO PRO A . n 
A 1 193 ASP 193 193 193 ASP ASP A . n 
A 1 194 HIS 194 194 194 HIS HIS A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PRO 196 196 196 PRO PRO A . n 
A 1 197 ASN 197 197 197 ASN ASN A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 ARG 199 199 199 ARG ARG A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 CYS 201 201 201 CYS CYS A . n 
A 1 202 LEU 202 202 202 LEU LEU A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 GLY 204 204 204 GLY GLY A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ASP 206 206 206 ASP ASP A . n 
A 1 207 ALA 207 207 207 ALA ALA A . n 
A 1 208 ASP 208 208 208 ASP ASP A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 ILE 210 210 210 ILE ILE A . n 
A 1 211 MET 211 211 211 MET MET A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 GLY 213 213 213 GLY GLY A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 HIS 217 217 217 HIS HIS A . n 
A 1 218 GLU 218 218 218 GLU GLU A . n 
A 1 219 ALA 219 219 219 ALA ALA A . n 
A 1 220 HIS 220 220 220 HIS HIS A . n 
A 1 221 PHE 221 221 221 PHE PHE A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 LEU 223 223 223 LEU LEU A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 ARG 225 225 225 ARG ARG A . n 
A 1 226 GLU 226 226 226 GLU GLU A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 ARG 229 229 229 ARG ARG A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 GLY 231 231 ?   ?   ?   A . n 
A 1 232 GLY 232 232 ?   ?   ?   A . n 
A 1 233 LYS 233 233 ?   ?   ?   A . n 
A 1 234 LYS 234 234 ?   ?   ?   A . n 
A 1 235 THR 235 235 ?   ?   ?   A . n 
A 1 236 GLN 236 236 ?   ?   ?   A . n 
A 1 237 ARG 237 237 ?   ?   ?   A . n 
A 1 238 VAL 238 238 ?   ?   ?   A . n 
A 1 239 CYS 239 239 ?   ?   ?   A . n 
A 1 240 ALA 240 240 ?   ?   ?   A . n 
A 1 241 PRO 241 241 ?   ?   ?   A . n 
A 1 242 GLU 242 242 ?   ?   ?   A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 THR 244 244 244 THR THR A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 PHE 246 246 246 PHE PHE A . n 
A 1 247 HIS 247 247 247 HIS HIS A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 HIS 250 250 250 HIS HIS A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 SER 252 252 252 SER SER A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 MET 254 254 254 MET MET A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 GLU 256 256 256 GLU GLU A . n 
A 1 257 TYR 257 257 257 TYR TYR A . n 
A 1 258 ILE 258 258 258 ILE ILE A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 GLU 261 261 261 GLU GLU A . n 
A 1 262 PHE 262 262 262 PHE PHE A . n 
A 1 263 SER 263 263 263 SER SER A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 LEU 265 265 265 LEU LEU A . n 
A 1 266 LYS 266 266 266 LYS LYS A . n 
A 1 267 GLU 267 267 267 GLU GLU A . n 
A 1 268 LYS 268 268 268 LYS LYS A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 THR 270 270 270 THR THR A . n 
A 1 271 PHE 271 271 271 PHE PHE A . n 
A 1 272 LYS 272 272 272 LYS LYS A . n 
A 1 273 TYR 273 273 273 TYR TYR A . n 
A 1 274 ASP 274 274 274 ASP ASP A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 GLU 276 276 276 GLU GLU A . n 
A 1 277 ARG 277 277 277 ARG ARG A . n 
A 1 278 ILE 278 278 278 ILE ILE A . n 
A 1 279 ILE 279 279 279 ILE ILE A . n 
A 1 280 ASP 280 280 280 ASP ASP A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 TRP 282 282 282 TRP TRP A . n 
A 1 283 ILE 283 283 283 ILE ILE A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 GLY 286 286 286 GLY GLY A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 LEU 288 288 288 LEU LEU A . n 
A 1 289 VAL 289 289 289 VAL VAL A . n 
A 1 290 GLY 290 290 290 GLY GLY A . n 
A 1 291 ASN 291 291 291 ASN ASN A . n 
A 1 292 ASP 292 292 292 ASP ASP A . n 
A 1 293 PHE 293 293 293 PHE PHE A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 PRO 295 295 295 PRO PRO A . n 
A 1 296 HIS 296 296 296 HIS HIS A . n 
A 1 297 LEU 297 297 297 LEU LEU A . n 
A 1 298 PRO 298 298 298 PRO PRO A . n 
A 1 299 HIS 299 299 299 HIS HIS A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 HIS 301 301 301 HIS HIS A . n 
A 1 302 ILE 302 302 302 ILE ILE A . n 
A 1 303 ASN 303 303 303 ASN ASN A . n 
A 1 304 HIS 304 304 304 HIS HIS A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 ALA 306 306 306 ALA ALA A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 PRO 308 308 308 PRO PRO A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 TYR 311 311 311 TYR TYR A . n 
A 1 312 GLY 312 312 312 GLY GLY A . n 
A 1 313 THR 313 313 313 THR THR A . n 
A 1 314 TYR 314 314 314 TYR TYR A . n 
A 1 315 VAL 315 315 315 VAL VAL A . n 
A 1 316 THR 316 316 316 THR THR A . n 
A 1 317 ILE 317 317 317 ILE ILE A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 PRO 319 319 319 PRO PRO A . n 
A 1 320 GLU 320 320 320 GLU GLU A . n 
A 1 321 LEU 321 321 321 LEU LEU A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 GLY 323 323 323 GLY GLY A . n 
A 1 324 TYR 324 324 324 TYR TYR A . n 
A 1 325 ILE 325 325 325 ILE ILE A . n 
A 1 326 ASN 326 326 326 ASN ASN A . n 
A 1 327 GLU 327 327 327 GLU GLU A . n 
A 1 328 SER 328 328 328 SER SER A . n 
A 1 329 GLY 329 329 329 GLY GLY A . n 
A 1 330 HIS 330 330 330 HIS HIS A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 ASN 332 332 332 ASN ASN A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 PRO 334 334 334 PRO PRO A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 PHE 336 336 336 PHE PHE A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 LYS 338 338 338 LYS LYS A . n 
A 1 339 TYR 339 339 339 TYR TYR A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 LYS 342 342 342 LYS LYS A . n 
A 1 343 LEU 343 343 343 LEU LEU A . n 
A 1 344 SER 344 344 344 SER SER A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 PHE 346 346 346 PHE PHE A . n 
A 1 347 ASP 347 347 347 ASP ASP A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 HIS 350 350 350 HIS HIS A . n 
A 1 351 PHE 351 351 351 PHE PHE A . n 
A 1 352 SER 352 352 352 SER SER A . n 
A 1 353 GLU 353 353 353 GLU GLU A . n 
A 1 354 VAL 354 354 354 VAL VAL A . n 
A 1 355 PHE 355 355 ?   ?   ?   A . n 
A 1 356 VAL 356 356 ?   ?   ?   A . n 
A 1 357 ASP 357 357 ?   ?   ?   A . n 
A 1 358 LEU 358 358 ?   ?   ?   A . n 
A 1 359 LYS 359 359 ?   ?   ?   A . n 
A 1 360 TRP 360 360 ?   ?   ?   A . n 
A 1 361 PHE 361 361 ?   ?   ?   A . n 
A 1 362 GLU 362 362 ?   ?   ?   A . n 
A 1 363 SER 363 363 ?   ?   ?   A . n 
A 1 364 LYS 364 364 ?   ?   ?   A . n 
A 1 365 VAL 365 365 ?   ?   ?   A . n 
A 1 366 GLY 366 366 ?   ?   ?   A . n 
A 1 367 ASN 367 367 ?   ?   ?   A . n 
A 1 368 LYS 368 368 ?   ?   ?   A . n 
A 1 369 TYR 369 369 ?   ?   ?   A . n 
A 1 370 LEU 370 370 ?   ?   ?   A . n 
A 1 371 ASN 371 371 ?   ?   ?   A . n 
A 1 372 GLU 372 372 ?   ?   ?   A . n 
A 1 373 ALA 373 373 ?   ?   ?   A . n 
A 1 374 ALA 374 374 ?   ?   ?   A . n 
A 1 375 GLY 375 375 ?   ?   ?   A . n 
A 1 376 VAL 376 376 ?   ?   ?   A . n 
A 1 377 ALA 377 377 ?   ?   ?   A . n 
A 1 378 ALA 378 378 ?   ?   ?   A . n 
A 1 379 GLU 379 379 ?   ?   ?   A . n 
A 1 380 GLU 380 380 ?   ?   ?   A . n 
A 1 381 ALA 381 381 ?   ?   ?   A . n 
A 1 382 ARG 382 382 ?   ?   ?   A . n 
A 1 383 ASN 383 383 ?   ?   ?   A . n 
A 1 384 TYR 384 384 ?   ?   ?   A . n 
A 1 385 LYS 385 385 ?   ?   ?   A . n 
A 1 386 GLU 386 386 ?   ?   ?   A . n 
A 1 387 LYS 387 387 ?   ?   ?   A . n 
A 1 388 LYS 388 388 ?   ?   ?   A . n 
A 1 389 LYS 389 389 ?   ?   ?   A . n 
A 1 390 LEU 390 390 ?   ?   ?   A . n 
A 1 391 LYS 391 391 ?   ?   ?   A . n 
A 1 392 GLY 392 392 ?   ?   ?   A . n 
A 1 393 GLN 393 393 ?   ?   ?   A . n 
A 1 394 GLU 394 394 ?   ?   ?   A . n 
A 1 395 ASN 395 395 ?   ?   ?   A . n 
A 1 396 SER 396 396 ?   ?   ?   A . n 
A 1 397 LEU 397 397 ?   ?   ?   A . n 
A 1 398 CYS 398 398 ?   ?   ?   A . n 
A 1 399 TRP 399 399 ?   ?   ?   A . n 
A 1 400 THR 400 400 ?   ?   ?   A . n 
A 1 401 ALA 401 401 ?   ?   ?   A . n 
A 1 402 LEU 402 402 ?   ?   ?   A . n 
A 1 403 ASP 403 403 ?   ?   ?   A . n 
A 1 404 LYS 404 404 ?   ?   ?   A . n 
A 1 405 ASN 405 405 ?   ?   ?   A . n 
A 1 406 GLU 406 406 ?   ?   ?   A . n 
A 1 407 GLY 407 407 ?   ?   ?   A . n 
A 1 408 GLU 408 408 ?   ?   ?   A . n 
A 1 409 MET 409 409 ?   ?   ?   A . n 
A 1 410 ILE 410 410 ?   ?   ?   A . n 
A 1 411 THR 411 411 ?   ?   ?   A . n 
A 1 412 SER 412 412 ?   ?   ?   A . n 
A 1 413 LYS 413 413 ?   ?   ?   A . n 
A 1 414 ASP 414 414 ?   ?   ?   A . n 
A 1 415 ASN 415 415 ?   ?   ?   A . n 
A 1 416 LEU 416 416 ?   ?   ?   A . n 
A 1 417 GLU 417 417 ?   ?   ?   A . n 
A 1 418 ASP 418 418 ?   ?   ?   A . n 
A 1 419 GLU 419 419 ?   ?   ?   A . n 
A 1 420 THR 420 420 ?   ?   ?   A . n 
A 1 421 GLU 421 421 ?   ?   ?   A . n 
A 1 422 ASP 422 422 ?   ?   ?   A . n 
A 1 423 ASP 423 423 ?   ?   ?   A . n 
A 1 424 ASP 424 424 424 ASP ASP A . n 
A 1 425 LEU 425 425 425 LEU LEU A . n 
A 1 426 PHE 426 426 426 PHE PHE A . n 
A 1 427 GLU 427 427 427 GLU GLU A . n 
A 1 428 THR 428 428 428 THR THR A . n 
A 1 429 GLU 429 429 429 GLU GLU A . n 
A 1 430 PHE 430 430 430 PHE PHE A . n 
A 1 431 ARG 431 431 431 ARG ARG A . n 
A 1 432 GLN 432 432 432 GLN GLN A . n 
A 1 433 TYR 433 433 433 TYR TYR A . n 
A 1 434 LYS 434 434 434 LYS LYS A . n 
A 1 435 ARG 435 435 435 ARG ARG A . n 
A 1 436 THR 436 436 436 THR THR A . n 
A 1 437 TYR 437 437 437 TYR TYR A . n 
A 1 438 TYR 438 438 438 TYR TYR A . n 
A 1 439 MET 439 439 439 MET MET A . n 
A 1 440 THR 440 440 440 THR THR A . n 
A 1 441 LYS 441 441 441 LYS LYS A . n 
A 1 442 MET 442 442 442 MET MET A . n 
A 1 443 GLY 443 443 443 GLY GLY A . n 
A 1 444 VAL 444 444 444 VAL VAL A . n 
A 1 445 ASP 445 445 445 ASP ASP A . n 
A 1 446 VAL 446 446 446 VAL VAL A . n 
A 1 447 VAL 447 447 447 VAL VAL A . n 
A 1 448 SER 448 448 448 SER SER A . n 
A 1 449 ASP 449 449 449 ASP ASP A . n 
A 1 450 ASP 450 450 450 ASP ASP A . n 
A 1 451 PHE 451 451 451 PHE PHE A . n 
A 1 452 LEU 452 452 452 LEU LEU A . n 
A 1 453 ALA 453 453 453 ALA ALA A . n 
A 1 454 ASP 454 454 454 ASP ASP A . n 
A 1 455 GLN 455 455 455 GLN GLN A . n 
A 1 456 ALA 456 456 456 ALA ALA A . n 
A 1 457 ALA 457 457 457 ALA ALA A . n 
A 1 458 CYS 458 458 458 CYS CYS A . n 
A 1 459 TYR 459 459 459 TYR TYR A . n 
A 1 460 VAL 460 460 460 VAL VAL A . n 
A 1 461 GLN 461 461 461 GLN GLN A . n 
A 1 462 ALA 462 462 462 ALA ALA A . n 
A 1 463 ILE 463 463 463 ILE ILE A . n 
A 1 464 GLN 464 464 464 GLN GLN A . n 
A 1 465 TRP 465 465 465 TRP TRP A . n 
A 1 466 ILE 466 466 466 ILE ILE A . n 
A 1 467 LEU 467 467 467 LEU LEU A . n 
A 1 468 HIS 468 468 468 HIS HIS A . n 
A 1 469 TYR 469 469 469 TYR TYR A . n 
A 1 470 TYR 470 470 470 TYR TYR A . n 
A 1 471 TYR 471 471 471 TYR TYR A . n 
A 1 472 HIS 472 472 472 HIS HIS A . n 
A 1 473 GLY 473 473 473 GLY GLY A . n 
A 1 474 VAL 474 474 474 VAL VAL A . n 
A 1 475 GLN 475 475 475 GLN GLN A . n 
A 1 476 SER 476 476 476 SER SER A . n 
A 1 477 TRP 477 477 477 TRP TRP A . n 
A 1 478 SER 478 478 478 SER SER A . n 
A 1 479 TRP 479 479 479 TRP TRP A . n 
A 1 480 TYR 480 480 480 TYR TYR A . n 
A 1 481 TYR 481 481 481 TYR TYR A . n 
A 1 482 PRO 482 482 482 PRO PRO A . n 
A 1 483 TYR 483 483 483 TYR TYR A . n 
A 1 484 HIS 484 484 484 HIS HIS A . n 
A 1 485 TYR 485 485 485 TYR TYR A . n 
A 1 486 ALA 486 486 486 ALA ALA A . n 
A 1 487 PRO 487 487 487 PRO PRO A . n 
A 1 488 PHE 488 488 488 PHE PHE A . n 
A 1 489 LEU 489 489 489 LEU LEU A . n 
A 1 490 SER 490 490 490 SER SER A . n 
A 1 491 ASP 491 491 491 ASP ASP A . n 
A 1 492 ILE 492 492 492 ILE ILE A . n 
A 1 493 HIS 493 493 493 HIS HIS A . n 
A 1 494 ASN 494 494 494 ASN ASN A . n 
A 1 495 ILE 495 495 495 ILE ILE A . n 
A 1 496 SER 496 496 496 SER SER A . n 
A 1 497 THR 497 497 497 THR THR A . n 
A 1 498 LEU 498 498 498 LEU LEU A . n 
A 1 499 LYS 499 499 499 LYS LYS A . n 
A 1 500 ILE 500 500 500 ILE ILE A . n 
A 1 501 HIS 501 501 501 HIS HIS A . n 
A 1 502 PHE 502 502 502 PHE PHE A . n 
A 1 503 GLU 503 503 503 GLU GLU A . n 
A 1 504 LEU 504 504 504 LEU LEU A . n 
A 1 505 GLY 505 505 505 GLY GLY A . n 
A 1 506 LYS 506 506 506 LYS LYS A . n 
A 1 507 PRO 507 507 507 PRO PRO A . n 
A 1 508 PHE 508 508 508 PHE PHE A . n 
A 1 509 LYS 509 509 509 LYS LYS A . n 
A 1 510 PRO 510 510 510 PRO PRO A . n 
A 1 511 PHE 511 511 511 PHE PHE A . n 
A 1 512 GLU 512 512 512 GLU GLU A . n 
A 1 513 GLN 513 513 513 GLN GLN A . n 
A 1 514 LEU 514 514 514 LEU LEU A . n 
A 1 515 LEU 515 515 515 LEU LEU A . n 
A 1 516 ALA 516 516 516 ALA ALA A . n 
A 1 517 VAL 517 517 517 VAL VAL A . n 
A 1 518 LEU 518 518 518 LEU LEU A . n 
A 1 519 PRO 519 519 519 PRO PRO A . n 
A 1 520 ALA 520 520 520 ALA ALA A . n 
A 1 521 ALA 521 521 521 ALA ALA A . n 
A 1 522 SER 522 522 522 SER SER A . n 
A 1 523 LYS 523 523 523 LYS LYS A . n 
A 1 524 ASN 524 524 524 ASN ASN A . n 
A 1 525 LEU 525 525 525 LEU LEU A . n 
A 1 526 LEU 526 526 526 LEU LEU A . n 
A 1 527 PRO 527 527 527 PRO PRO A . n 
A 1 528 ALA 528 528 528 ALA ALA A . n 
A 1 529 CYS 529 529 529 CYS CYS A . n 
A 1 530 TYR 530 530 530 TYR TYR A . n 
A 1 531 GLN 531 531 531 GLN GLN A . n 
A 1 532 HIS 532 532 532 HIS HIS A . n 
A 1 533 LEU 533 533 533 LEU LEU A . n 
A 1 534 MET 534 534 534 MET MET A . n 
A 1 535 THR 535 535 535 THR THR A . n 
A 1 536 ASN 536 536 536 ASN ASN A . n 
A 1 537 GLU 537 537 537 GLU GLU A . n 
A 1 538 ASP 538 538 538 ASP ASP A . n 
A 1 539 SER 539 539 539 SER SER A . n 
A 1 540 PRO 540 540 540 PRO PRO A . n 
A 1 541 ILE 541 541 541 ILE ILE A . n 
A 1 542 ILE 542 542 542 ILE ILE A . n 
A 1 543 GLU 543 543 543 GLU GLU A . n 
A 1 544 TYR 544 544 544 TYR TYR A . n 
A 1 545 TYR 545 545 545 TYR TYR A . n 
A 1 546 PRO 546 546 546 PRO PRO A . n 
A 1 547 PRO 547 547 547 PRO PRO A . n 
A 1 548 ASP 548 548 548 ASP ASP A . n 
A 1 549 PHE 549 549 549 PHE PHE A . n 
A 1 550 LYS 550 550 550 LYS LYS A . n 
A 1 551 THR 551 551 551 THR THR A . n 
A 1 552 ASP 552 552 552 ASP ASP A . n 
A 1 553 LEU 553 553 553 LEU LEU A . n 
A 1 554 ASN 554 554 554 ASN ASN A . n 
A 1 555 GLY 555 555 555 GLY GLY A . n 
A 1 556 LYS 556 556 ?   ?   ?   A . n 
A 1 557 GLN 557 557 ?   ?   ?   A . n 
A 1 558 GLN 558 558 ?   ?   ?   A . n 
A 1 559 GLU 559 559 559 GLU GLU A . n 
A 1 560 TRP 560 560 560 TRP TRP A . n 
A 1 561 GLU 561 561 561 GLU GLU A . n 
A 1 562 ALA 562 562 562 ALA ALA A . n 
A 1 563 VAL 563 563 563 VAL VAL A . n 
A 1 564 VAL 564 564 564 VAL VAL A . n 
A 1 565 LEU 565 565 565 LEU LEU A . n 
A 1 566 ILE 566 566 566 ILE ILE A . n 
A 1 567 PRO 567 567 567 PRO PRO A . n 
A 1 568 PHE 568 568 568 PHE PHE A . n 
A 1 569 ILE 569 569 569 ILE ILE A . n 
A 1 570 ASP 570 570 570 ASP ASP A . n 
A 1 571 GLU 571 571 571 GLU GLU A . n 
A 1 572 LYS 572 572 572 LYS LYS A . n 
A 1 573 ARG 573 573 573 ARG ARG A . n 
A 1 574 LEU 574 574 574 LEU LEU A . n 
A 1 575 LEU 575 575 575 LEU LEU A . n 
A 1 576 GLU 576 576 576 GLU GLU A . n 
A 1 577 ALA 577 577 577 ALA ALA A . n 
A 1 578 MET 578 578 578 MET MET A . n 
A 1 579 GLU 579 579 579 GLU GLU A . n 
A 1 580 THR 580 580 580 THR THR A . n 
A 1 581 CYS 581 581 581 CYS CYS A . n 
A 1 582 ASN 582 582 582 ASN ASN A . n 
A 1 583 HIS 583 583 583 HIS HIS A . n 
A 1 584 SER 584 584 584 SER SER A . n 
A 1 585 LEU 585 585 585 LEU LEU A . n 
A 1 586 LYS 586 586 586 LYS LYS A . n 
A 1 587 LYS 587 587 587 LYS LYS A . n 
A 1 588 GLU 588 588 588 GLU GLU A . n 
A 1 589 GLU 589 589 589 GLU GLU A . n 
A 1 590 ARG 590 590 590 ARG ARG A . n 
A 1 591 LYS 591 591 591 LYS LYS A . n 
A 1 592 ARG 592 592 592 ARG ARG A . n 
A 1 593 ASN 593 593 593 ASN ASN A . n 
A 1 594 GLN 594 594 594 GLN GLN A . n 
A 1 595 HIS 595 595 595 HIS HIS A . n 
A 1 596 SER 596 596 596 SER SER A . n 
A 1 597 GLU 597 597 597 GLU GLU A . n 
A 1 598 CYS 598 598 598 CYS CYS A . n 
A 1 599 LEU 599 599 599 LEU LEU A . n 
A 1 600 MET 600 600 600 MET MET A . n 
A 1 601 CYS 601 601 601 CYS CYS A . n 
A 1 602 TRP 602 602 602 TRP TRP A . n 
A 1 603 TYR 603 603 603 TYR TYR A . n 
A 1 604 ASP 604 604 604 ASP ASP A . n 
A 1 605 ARG 605 605 605 ARG ARG A . n 
A 1 606 ASP 606 606 606 ASP ASP A . n 
A 1 607 THR 607 607 607 THR THR A . n 
A 1 608 GLU 608 608 608 GLU GLU A . n 
A 1 609 PHE 609 609 609 PHE PHE A . n 
A 1 610 ILE 610 610 610 ILE ILE A . n 
A 1 611 TYR 611 611 611 TYR TYR A . n 
A 1 612 PRO 612 612 612 PRO PRO A . n 
A 1 613 SER 613 613 613 SER SER A . n 
A 1 614 PRO 614 614 614 PRO PRO A . n 
A 1 615 TRP 615 615 615 TRP TRP A . n 
A 1 616 PRO 616 616 616 PRO PRO A . n 
A 1 617 GLU 617 617 617 GLU GLU A . n 
A 1 618 LYS 618 618 618 LYS LYS A . n 
A 1 619 PHE 619 619 619 PHE PHE A . n 
A 1 620 PRO 620 620 620 PRO PRO A . n 
A 1 621 ALA 621 621 621 ALA ALA A . n 
A 1 622 ILE 622 622 622 ILE ILE A . n 
A 1 623 GLU 623 623 623 GLU GLU A . n 
A 1 624 ARG 624 624 624 ARG ARG A . n 
A 1 625 CYS 625 625 625 CYS CYS A . n 
A 1 626 CYS 626 626 626 CYS CYS A . n 
A 1 627 THR 627 627 627 THR THR A . n 
A 1 628 ARG 628 628 628 ARG ARG A . n 
A 1 629 TYR 629 629 629 TYR TYR A . n 
A 1 630 LYS 630 630 630 LYS LYS A . n 
A 1 631 ILE 631 631 631 ILE ILE A . n 
A 1 632 ILE 632 632 632 ILE ILE A . n 
A 1 633 SER 633 633 633 SER SER A . n 
A 1 634 LEU 634 634 634 LEU LEU A . n 
A 1 635 ASP 635 635 635 ASP ASP A . n 
A 1 636 ALA 636 636 636 ALA ALA A . n 
A 1 637 TRP 637 637 637 TRP TRP A . n 
A 1 638 ARG 638 638 638 ARG ARG A . n 
A 1 639 VAL 639 639 639 VAL VAL A . n 
A 1 640 ASP 640 640 640 ASP ASP A . n 
A 1 641 ILE 641 641 641 ILE ILE A . n 
A 1 642 ASN 642 642 ?   ?   ?   A . n 
A 1 643 LYS 643 643 ?   ?   ?   A . n 
A 1 644 ASN 644 644 ?   ?   ?   A . n 
A 1 645 LYS 645 645 ?   ?   ?   A . n 
A 1 646 ILE 646 646 ?   ?   ?   A . n 
A 1 647 THR 647 647 ?   ?   ?   A . n 
A 1 648 ARG 648 648 ?   ?   ?   A . n 
A 1 649 ILE 649 649 ?   ?   ?   A . n 
A 1 650 ASP 650 650 ?   ?   ?   A . n 
A 1 651 GLN 651 651 ?   ?   ?   A . n 
A 1 652 LYS 652 652 ?   ?   ?   A . n 
A 1 653 ALA 653 653 ?   ?   ?   A . n 
A 1 654 ASP 654 654 ?   ?   ?   A . n 
A 1 655 TYR 655 655 ?   ?   ?   A . n 
A 1 656 LYS 656 656 ?   ?   ?   A . n 
A 1 657 ASP 657 657 ?   ?   ?   A . n 
A 1 658 ASP 658 658 ?   ?   ?   A . n 
A 1 659 ASP 659 659 ?   ?   ?   A . n 
A 1 660 ASP 660 660 ?   ?   ?   A . n 
A 1 661 LYS 661 661 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLY 2   2   2   GLY GLY B . n 
B 1 3   VAL 3   3   3   VAL VAL B . n 
B 1 4   PRO 4   4   4   PRO PRO B . n 
B 1 5   LYS 5   5   5   LYS LYS B . n 
B 1 6   PHE 6   6   6   PHE PHE B . n 
B 1 7   TYR 7   7   7   TYR TYR B . n 
B 1 8   ARG 8   8   8   ARG ARG B . n 
B 1 9   TRP 9   9   9   TRP TRP B . n 
B 1 10  ILE 10  10  10  ILE ILE B . n 
B 1 11  SER 11  11  11  SER SER B . n 
B 1 12  GLU 12  12  12  GLU GLU B . n 
B 1 13  ARG 13  13  13  ARG ARG B . n 
B 1 14  TYR 14  14  14  TYR TYR B . n 
B 1 15  PRO 15  15  15  PRO PRO B . n 
B 1 16  CYS 16  16  16  CYS CYS B . n 
B 1 17  LEU 17  17  17  LEU LEU B . n 
B 1 18  SER 18  18  18  SER SER B . n 
B 1 19  GLU 19  19  19  GLU GLU B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  VAL 21  21  21  VAL VAL B . n 
B 1 22  LYS 22  22  22  LYS LYS B . n 
B 1 23  GLU 23  23  23  GLU GLU B . n 
B 1 24  HIS 24  24  24  HIS HIS B . n 
B 1 25  GLN 25  25  25  GLN GLN B . n 
B 1 26  ILE 26  26  26  ILE ILE B . n 
B 1 27  PRO 27  27  27  PRO PRO B . n 
B 1 28  GLU 28  28  28  GLU GLU B . n 
B 1 29  PHE 29  29  29  PHE PHE B . n 
B 1 30  ASP 30  30  30  ASP ASP B . n 
B 1 31  ASN 31  31  31  ASN ASN B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  TYR 33  33  33  TYR TYR B . n 
B 1 34  LEU 34  34  34  LEU LEU B . n 
B 1 35  ASP 35  35  35  ASP ASP B . n 
B 1 36  MET 36  36  36  MET MET B . n 
B 1 37  ASN 37  37  37  ASN ASN B . n 
B 1 38  GLY 38  38  38  GLY GLY B . n 
B 1 39  ILE 39  39  39  ILE ILE B . n 
B 1 40  ILE 40  40  40  ILE ILE B . n 
B 1 41  HIS 41  41  41  HIS HIS B . n 
B 1 42  GLN 42  42  42  GLN GLN B . n 
B 1 43  CYS 43  43  43  CYS CYS B . n 
B 1 44  SER 44  44  44  SER SER B . n 
B 1 45  HIS 45  45  45  HIS HIS B . n 
B 1 46  PRO 46  46  46  PRO PRO B . n 
B 1 47  ASN 47  47  47  ASN ASN B . n 
B 1 48  ASP 48  48  48  ASP ASP B . n 
B 1 49  ASP 49  49  49  ASP ASP B . n 
B 1 50  ASP 50  50  50  ASP ASP B . n 
B 1 51  VAL 51  51  51  VAL VAL B . n 
B 1 52  HIS 52  52  52  HIS HIS B . n 
B 1 53  PHE 53  53  53  PHE PHE B . n 
B 1 54  ARG 54  54  54  ARG ARG B . n 
B 1 55  ILE 55  55  55  ILE ILE B . n 
B 1 56  SER 56  56  56  SER SER B . n 
B 1 57  ASP 57  57  57  ASP ASP B . n 
B 1 58  ASP 58  58  58  ASP ASP B . n 
B 1 59  LYS 59  59  59  LYS LYS B . n 
B 1 60  ILE 60  60  60  ILE ILE B . n 
B 1 61  PHE 61  61  61  PHE PHE B . n 
B 1 62  THR 62  62  62  THR THR B . n 
B 1 63  ASP 63  63  63  ASP ASP B . n 
B 1 64  ILE 64  64  64  ILE ILE B . n 
B 1 65  PHE 65  65  65  PHE PHE B . n 
B 1 66  HIS 66  66  66  HIS HIS B . n 
B 1 67  TYR 67  67  67  TYR TYR B . n 
B 1 68  LEU 68  68  68  LEU LEU B . n 
B 1 69  GLU 69  69  69  GLU GLU B . n 
B 1 70  VAL 70  70  70  VAL VAL B . n 
B 1 71  LEU 71  71  71  LEU LEU B . n 
B 1 72  PHE 72  72  72  PHE PHE B . n 
B 1 73  ARG 73  73  73  ARG ARG B . n 
B 1 74  ILE 74  74  74  ILE ILE B . n 
B 1 75  ILE 75  75  75  ILE ILE B . n 
B 1 76  LYS 76  76  76  LYS LYS B . n 
B 1 77  PRO 77  77  77  PRO PRO B . n 
B 1 78  ARG 78  78  78  ARG ARG B . n 
B 1 79  LYS 79  79  79  LYS LYS B . n 
B 1 80  VAL 80  80  80  VAL VAL B . n 
B 1 81  PHE 81  81  81  PHE PHE B . n 
B 1 82  PHE 82  82  82  PHE PHE B . n 
B 1 83  MET 83  83  83  MET MET B . n 
B 1 84  ALA 84  84  84  ALA ALA B . n 
B 1 85  VAL 85  85  85  VAL VAL B . n 
B 1 86  ASP 86  86  86  ASP ASP B . n 
B 1 87  GLY 87  87  87  GLY GLY B . n 
B 1 88  VAL 88  88  88  VAL VAL B . n 
B 1 89  ALA 89  89  89  ALA ALA B . n 
B 1 90  PRO 90  90  90  PRO PRO B . n 
B 1 91  ARG 91  91  91  ARG ARG B . n 
B 1 92  ALA 92  92  92  ALA ALA B . n 
B 1 93  LYS 93  93  93  LYS LYS B . n 
B 1 94  MET 94  94  94  MET MET B . n 
B 1 95  ASN 95  95  95  ASN ASN B . n 
B 1 96  GLN 96  96  96  GLN GLN B . n 
B 1 97  GLN 97  97  97  GLN GLN B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  GLY 99  99  99  GLY GLY B . n 
B 1 100 ARG 100 100 100 ARG ARG B . n 
B 1 101 ARG 101 101 101 ARG ARG B . n 
B 1 102 PHE 102 102 102 PHE PHE B . n 
B 1 103 ARG 103 103 103 ARG ARG B . n 
B 1 104 SER 104 104 104 SER SER B . n 
B 1 105 ALA 105 105 105 ALA ALA B . n 
B 1 106 LYS 106 106 106 LYS LYS B . n 
B 1 107 GLU 107 107 107 GLU GLU B . n 
B 1 108 ALA 108 108 108 ALA ALA B . n 
B 1 109 GLU 109 109 109 GLU GLU B . n 
B 1 110 ASP 110 110 110 ASP ASP B . n 
B 1 111 LYS 111 111 111 LYS LYS B . n 
B 1 112 ILE 112 112 112 ILE ILE B . n 
B 1 113 LYS 113 113 113 LYS LYS B . n 
B 1 114 LYS 114 114 114 LYS LYS B . n 
B 1 115 ALA 115 115 115 ALA ALA B . n 
B 1 116 ILE 116 116 116 ILE ILE B . n 
B 1 117 GLU 117 117 117 GLU GLU B . n 
B 1 118 LYS 118 118 118 LYS LYS B . n 
B 1 119 GLY 119 119 119 GLY GLY B . n 
B 1 120 GLU 120 120 120 GLU GLU B . n 
B 1 121 THR 121 121 121 THR THR B . n 
B 1 122 LEU 122 122 122 LEU LEU B . n 
B 1 123 PRO 123 123 123 PRO PRO B . n 
B 1 124 THR 124 124 124 THR THR B . n 
B 1 125 GLU 125 125 125 GLU GLU B . n 
B 1 126 ALA 126 126 126 ALA ALA B . n 
B 1 127 ARG 127 127 127 ARG ARG B . n 
B 1 128 PHE 128 128 128 PHE PHE B . n 
B 1 129 ASP 129 129 129 ASP ASP B . n 
B 1 130 SER 130 130 130 SER SER B . n 
B 1 131 ASN 131 131 131 ASN ASN B . n 
B 1 132 CYS 132 132 132 CYS CYS B . n 
B 1 133 ILE 133 133 133 ILE ILE B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 PRO 135 135 135 PRO PRO B . n 
B 1 136 GLY 136 136 136 GLY GLY B . n 
B 1 137 THR 137 137 137 THR THR B . n 
B 1 138 GLU 138 138 138 GLU GLU B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 MET 140 140 140 MET MET B . n 
B 1 141 ALA 141 141 141 ALA ALA B . n 
B 1 142 ARG 142 142 142 ARG ARG B . n 
B 1 143 LEU 143 143 143 LEU LEU B . n 
B 1 144 HIS 144 144 144 HIS HIS B . n 
B 1 145 GLU 145 145 145 GLU GLU B . n 
B 1 146 HIS 146 146 146 HIS HIS B . n 
B 1 147 LEU 147 147 147 LEU LEU B . n 
B 1 148 LYS 148 148 148 LYS LYS B . n 
B 1 149 TYR 149 149 149 TYR TYR B . n 
B 1 150 PHE 150 150 150 PHE PHE B . n 
B 1 151 VAL 151 151 151 VAL VAL B . n 
B 1 152 ASN 152 152 152 ASN ASN B . n 
B 1 153 MET 153 153 153 MET MET B . n 
B 1 154 LYS 154 154 154 LYS LYS B . n 
B 1 155 ILE 155 155 155 ILE ILE B . n 
B 1 156 SER 156 156 156 SER SER B . n 
B 1 157 THR 157 157 157 THR THR B . n 
B 1 158 ASP 158 158 158 ASP ASP B . n 
B 1 159 LYS 159 159 159 LYS LYS B . n 
B 1 160 SER 160 160 160 SER SER B . n 
B 1 161 TRP 161 161 161 TRP TRP B . n 
B 1 162 GLN 162 162 162 GLN GLN B . n 
B 1 163 GLY 163 163 163 GLY GLY B . n 
B 1 164 VAL 164 164 164 VAL VAL B . n 
B 1 165 THR 165 165 165 THR THR B . n 
B 1 166 ILE 166 166 166 ILE ILE B . n 
B 1 167 TYR 167 167 167 TYR TYR B . n 
B 1 168 PHE 168 168 168 PHE PHE B . n 
B 1 169 SER 169 169 169 SER SER B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 HIS 171 171 171 HIS HIS B . n 
B 1 172 GLU 172 172 172 GLU GLU B . n 
B 1 173 THR 173 173 173 THR THR B . n 
B 1 174 PRO 174 174 174 PRO PRO B . n 
B 1 175 GLY 175 175 175 GLY GLY B . n 
B 1 176 GLU 176 176 176 GLU GLU B . n 
B 1 177 GLY 177 177 177 GLY GLY B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 HIS 179 179 179 HIS HIS B . n 
B 1 180 LYS 180 180 180 LYS LYS B . n 
B 1 181 ILE 181 181 181 ILE ILE B . n 
B 1 182 MET 182 182 182 MET MET B . n 
B 1 183 GLU 183 183 183 GLU GLU B . n 
B 1 184 PHE 184 184 184 PHE PHE B . n 
B 1 185 ILE 185 185 185 ILE ILE B . n 
B 1 186 ARG 186 186 186 ARG ARG B . n 
B 1 187 SER 187 187 187 SER SER B . n 
B 1 188 GLU 188 188 188 GLU GLU B . n 
B 1 189 LYS 189 189 189 LYS LYS B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 LYS 191 191 191 LYS LYS B . n 
B 1 192 PRO 192 192 192 PRO PRO B . n 
B 1 193 ASP 193 193 193 ASP ASP B . n 
B 1 194 HIS 194 194 194 HIS HIS B . n 
B 1 195 ASP 195 195 195 ASP ASP B . n 
B 1 196 PRO 196 196 196 PRO PRO B . n 
B 1 197 ASN 197 197 197 ASN ASN B . n 
B 1 198 THR 198 198 198 THR THR B . n 
B 1 199 ARG 199 199 199 ARG ARG B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 CYS 201 201 201 CYS CYS B . n 
B 1 202 LEU 202 202 202 LEU LEU B . n 
B 1 203 TYR 203 203 203 TYR TYR B . n 
B 1 204 GLY 204 204 204 GLY GLY B . n 
B 1 205 LEU 205 205 205 LEU LEU B . n 
B 1 206 ASP 206 206 206 ASP ASP B . n 
B 1 207 ALA 207 207 207 ALA ALA B . n 
B 1 208 ASP 208 208 208 ASP ASP B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 ILE 210 210 210 ILE ILE B . n 
B 1 211 MET 211 211 211 MET MET B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 GLY 213 213 213 GLY GLY B . n 
B 1 214 LEU 214 214 214 LEU LEU B . n 
B 1 215 THR 215 215 215 THR THR B . n 
B 1 216 SER 216 216 216 SER SER B . n 
B 1 217 HIS 217 217 217 HIS HIS B . n 
B 1 218 GLU 218 218 218 GLU GLU B . n 
B 1 219 ALA 219 219 219 ALA ALA B . n 
B 1 220 HIS 220 220 220 HIS HIS B . n 
B 1 221 PHE 221 221 221 PHE PHE B . n 
B 1 222 SER 222 222 222 SER SER B . n 
B 1 223 LEU 223 223 223 LEU LEU B . n 
B 1 224 LEU 224 224 224 LEU LEU B . n 
B 1 225 ARG 225 225 225 ARG ARG B . n 
B 1 226 GLU 226 226 226 GLU GLU B . n 
B 1 227 GLU 227 227 227 GLU GLU B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 ARG 229 229 229 ARG ARG B . n 
B 1 230 PHE 230 230 230 PHE PHE B . n 
B 1 231 GLY 231 231 ?   ?   ?   B . n 
B 1 232 GLY 232 232 ?   ?   ?   B . n 
B 1 233 LYS 233 233 ?   ?   ?   B . n 
B 1 234 LYS 234 234 ?   ?   ?   B . n 
B 1 235 THR 235 235 ?   ?   ?   B . n 
B 1 236 GLN 236 236 ?   ?   ?   B . n 
B 1 237 ARG 237 237 ?   ?   ?   B . n 
B 1 238 VAL 238 238 ?   ?   ?   B . n 
B 1 239 CYS 239 239 ?   ?   ?   B . n 
B 1 240 ALA 240 240 ?   ?   ?   B . n 
B 1 241 PRO 241 241 ?   ?   ?   B . n 
B 1 242 GLU 242 242 ?   ?   ?   B . n 
B 1 243 GLU 243 243 ?   ?   ?   B . n 
B 1 244 THR 244 244 244 THR THR B . n 
B 1 245 THR 245 245 245 THR THR B . n 
B 1 246 PHE 246 246 246 PHE PHE B . n 
B 1 247 HIS 247 247 247 HIS HIS B . n 
B 1 248 LEU 248 248 248 LEU LEU B . n 
B 1 249 LEU 249 249 249 LEU LEU B . n 
B 1 250 HIS 250 250 250 HIS HIS B . n 
B 1 251 LEU 251 251 251 LEU LEU B . n 
B 1 252 SER 252 252 252 SER SER B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 MET 254 254 254 MET MET B . n 
B 1 255 ARG 255 255 255 ARG ARG B . n 
B 1 256 GLU 256 256 256 GLU GLU B . n 
B 1 257 TYR 257 257 257 TYR TYR B . n 
B 1 258 ILE 258 258 258 ILE ILE B . n 
B 1 259 ASP 259 259 259 ASP ASP B . n 
B 1 260 TYR 260 260 260 TYR TYR B . n 
B 1 261 GLU 261 261 261 GLU GLU B . n 
B 1 262 PHE 262 262 262 PHE PHE B . n 
B 1 263 SER 263 263 263 SER SER B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 LEU 265 265 265 LEU LEU B . n 
B 1 266 LYS 266 266 266 LYS LYS B . n 
B 1 267 GLU 267 267 267 GLU GLU B . n 
B 1 268 LYS 268 268 268 LYS LYS B . n 
B 1 269 ILE 269 269 269 ILE ILE B . n 
B 1 270 THR 270 270 270 THR THR B . n 
B 1 271 PHE 271 271 271 PHE PHE B . n 
B 1 272 LYS 272 272 272 LYS LYS B . n 
B 1 273 TYR 273 273 273 TYR TYR B . n 
B 1 274 ASP 274 274 274 ASP ASP B . n 
B 1 275 ILE 275 275 275 ILE ILE B . n 
B 1 276 GLU 276 276 276 GLU GLU B . n 
B 1 277 ARG 277 277 277 ARG ARG B . n 
B 1 278 ILE 278 278 278 ILE ILE B . n 
B 1 279 ILE 279 279 279 ILE ILE B . n 
B 1 280 ASP 280 280 280 ASP ASP B . n 
B 1 281 ASP 281 281 281 ASP ASP B . n 
B 1 282 TRP 282 282 282 TRP TRP B . n 
B 1 283 ILE 283 283 283 ILE ILE B . n 
B 1 284 LEU 284 284 284 LEU LEU B . n 
B 1 285 MET 285 285 285 MET MET B . n 
B 1 286 GLY 286 286 286 GLY GLY B . n 
B 1 287 PHE 287 287 287 PHE PHE B . n 
B 1 288 LEU 288 288 288 LEU LEU B . n 
B 1 289 VAL 289 289 289 VAL VAL B . n 
B 1 290 GLY 290 290 290 GLY GLY B . n 
B 1 291 ASN 291 291 291 ASN ASN B . n 
B 1 292 ASP 292 292 292 ASP ASP B . n 
B 1 293 PHE 293 293 293 PHE PHE B . n 
B 1 294 ILE 294 294 294 ILE ILE B . n 
B 1 295 PRO 295 295 295 PRO PRO B . n 
B 1 296 HIS 296 296 296 HIS HIS B . n 
B 1 297 LEU 297 297 297 LEU LEU B . n 
B 1 298 PRO 298 298 298 PRO PRO B . n 
B 1 299 HIS 299 299 299 HIS HIS B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 HIS 301 301 301 HIS HIS B . n 
B 1 302 ILE 302 302 302 ILE ILE B . n 
B 1 303 ASN 303 303 303 ASN ASN B . n 
B 1 304 HIS 304 304 304 HIS HIS B . n 
B 1 305 ASP 305 305 305 ASP ASP B . n 
B 1 306 ALA 306 306 306 ALA ALA B . n 
B 1 307 LEU 307 307 307 LEU LEU B . n 
B 1 308 PRO 308 308 308 PRO PRO B . n 
B 1 309 LEU 309 309 309 LEU LEU B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 TYR 311 311 311 TYR TYR B . n 
B 1 312 GLY 312 312 312 GLY GLY B . n 
B 1 313 THR 313 313 313 THR THR B . n 
B 1 314 TYR 314 314 314 TYR TYR B . n 
B 1 315 VAL 315 315 315 VAL VAL B . n 
B 1 316 THR 316 316 316 THR THR B . n 
B 1 317 ILE 317 317 317 ILE ILE B . n 
B 1 318 LEU 318 318 318 LEU LEU B . n 
B 1 319 PRO 319 319 319 PRO PRO B . n 
B 1 320 GLU 320 320 320 GLU GLU B . n 
B 1 321 LEU 321 321 321 LEU LEU B . n 
B 1 322 GLY 322 322 322 GLY GLY B . n 
B 1 323 GLY 323 323 323 GLY GLY B . n 
B 1 324 TYR 324 324 324 TYR TYR B . n 
B 1 325 ILE 325 325 325 ILE ILE B . n 
B 1 326 ASN 326 326 326 ASN ASN B . n 
B 1 327 GLU 327 327 327 GLU GLU B . n 
B 1 328 SER 328 328 328 SER SER B . n 
B 1 329 GLY 329 329 329 GLY GLY B . n 
B 1 330 HIS 330 330 330 HIS HIS B . n 
B 1 331 LEU 331 331 331 LEU LEU B . n 
B 1 332 ASN 332 332 332 ASN ASN B . n 
B 1 333 LEU 333 333 333 LEU LEU B . n 
B 1 334 PRO 334 334 334 PRO PRO B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 PHE 336 336 336 PHE PHE B . n 
B 1 337 GLU 337 337 337 GLU GLU B . n 
B 1 338 LYS 338 338 338 LYS LYS B . n 
B 1 339 TYR 339 339 339 TYR TYR B . n 
B 1 340 LEU 340 340 340 LEU LEU B . n 
B 1 341 VAL 341 341 341 VAL VAL B . n 
B 1 342 LYS 342 342 342 LYS LYS B . n 
B 1 343 LEU 343 343 343 LEU LEU B . n 
B 1 344 SER 344 344 344 SER SER B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 PHE 346 346 346 PHE PHE B . n 
B 1 347 ASP 347 347 347 ASP ASP B . n 
B 1 348 ARG 348 348 348 ARG ARG B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 HIS 350 350 350 HIS HIS B . n 
B 1 351 PHE 351 351 351 PHE PHE B . n 
B 1 352 SER 352 352 352 SER SER B . n 
B 1 353 GLU 353 353 353 GLU GLU B . n 
B 1 354 VAL 354 354 354 VAL VAL B . n 
B 1 355 PHE 355 355 355 PHE PHE B . n 
B 1 356 VAL 356 356 356 VAL VAL B . n 
B 1 357 ASP 357 357 357 ASP ASP B . n 
B 1 358 LEU 358 358 358 LEU LEU B . n 
B 1 359 LYS 359 359 359 LYS LYS B . n 
B 1 360 TRP 360 360 360 TRP TRP B . n 
B 1 361 PHE 361 361 ?   ?   ?   B . n 
B 1 362 GLU 362 362 ?   ?   ?   B . n 
B 1 363 SER 363 363 ?   ?   ?   B . n 
B 1 364 LYS 364 364 ?   ?   ?   B . n 
B 1 365 VAL 365 365 ?   ?   ?   B . n 
B 1 366 GLY 366 366 ?   ?   ?   B . n 
B 1 367 ASN 367 367 ?   ?   ?   B . n 
B 1 368 LYS 368 368 ?   ?   ?   B . n 
B 1 369 TYR 369 369 ?   ?   ?   B . n 
B 1 370 LEU 370 370 ?   ?   ?   B . n 
B 1 371 ASN 371 371 ?   ?   ?   B . n 
B 1 372 GLU 372 372 ?   ?   ?   B . n 
B 1 373 ALA 373 373 ?   ?   ?   B . n 
B 1 374 ALA 374 374 ?   ?   ?   B . n 
B 1 375 GLY 375 375 ?   ?   ?   B . n 
B 1 376 VAL 376 376 ?   ?   ?   B . n 
B 1 377 ALA 377 377 ?   ?   ?   B . n 
B 1 378 ALA 378 378 ?   ?   ?   B . n 
B 1 379 GLU 379 379 ?   ?   ?   B . n 
B 1 380 GLU 380 380 ?   ?   ?   B . n 
B 1 381 ALA 381 381 ?   ?   ?   B . n 
B 1 382 ARG 382 382 ?   ?   ?   B . n 
B 1 383 ASN 383 383 ?   ?   ?   B . n 
B 1 384 TYR 384 384 ?   ?   ?   B . n 
B 1 385 LYS 385 385 ?   ?   ?   B . n 
B 1 386 GLU 386 386 ?   ?   ?   B . n 
B 1 387 LYS 387 387 ?   ?   ?   B . n 
B 1 388 LYS 388 388 ?   ?   ?   B . n 
B 1 389 LYS 389 389 ?   ?   ?   B . n 
B 1 390 LEU 390 390 ?   ?   ?   B . n 
B 1 391 LYS 391 391 ?   ?   ?   B . n 
B 1 392 GLY 392 392 ?   ?   ?   B . n 
B 1 393 GLN 393 393 ?   ?   ?   B . n 
B 1 394 GLU 394 394 ?   ?   ?   B . n 
B 1 395 ASN 395 395 ?   ?   ?   B . n 
B 1 396 SER 396 396 ?   ?   ?   B . n 
B 1 397 LEU 397 397 ?   ?   ?   B . n 
B 1 398 CYS 398 398 ?   ?   ?   B . n 
B 1 399 TRP 399 399 ?   ?   ?   B . n 
B 1 400 THR 400 400 ?   ?   ?   B . n 
B 1 401 ALA 401 401 ?   ?   ?   B . n 
B 1 402 LEU 402 402 ?   ?   ?   B . n 
B 1 403 ASP 403 403 ?   ?   ?   B . n 
B 1 404 LYS 404 404 ?   ?   ?   B . n 
B 1 405 ASN 405 405 ?   ?   ?   B . n 
B 1 406 GLU 406 406 ?   ?   ?   B . n 
B 1 407 GLY 407 407 ?   ?   ?   B . n 
B 1 408 GLU 408 408 ?   ?   ?   B . n 
B 1 409 MET 409 409 ?   ?   ?   B . n 
B 1 410 ILE 410 410 ?   ?   ?   B . n 
B 1 411 THR 411 411 ?   ?   ?   B . n 
B 1 412 SER 412 412 ?   ?   ?   B . n 
B 1 413 LYS 413 413 ?   ?   ?   B . n 
B 1 414 ASP 414 414 ?   ?   ?   B . n 
B 1 415 ASN 415 415 ?   ?   ?   B . n 
B 1 416 LEU 416 416 ?   ?   ?   B . n 
B 1 417 GLU 417 417 ?   ?   ?   B . n 
B 1 418 ASP 418 418 ?   ?   ?   B . n 
B 1 419 GLU 419 419 ?   ?   ?   B . n 
B 1 420 THR 420 420 ?   ?   ?   B . n 
B 1 421 GLU 421 421 ?   ?   ?   B . n 
B 1 422 ASP 422 422 ?   ?   ?   B . n 
B 1 423 ASP 423 423 ?   ?   ?   B . n 
B 1 424 ASP 424 424 ?   ?   ?   B . n 
B 1 425 LEU 425 425 425 LEU LEU B . n 
B 1 426 PHE 426 426 426 PHE PHE B . n 
B 1 427 GLU 427 427 427 GLU GLU B . n 
B 1 428 THR 428 428 428 THR THR B . n 
B 1 429 GLU 429 429 429 GLU GLU B . n 
B 1 430 PHE 430 430 430 PHE PHE B . n 
B 1 431 ARG 431 431 431 ARG ARG B . n 
B 1 432 GLN 432 432 432 GLN GLN B . n 
B 1 433 TYR 433 433 433 TYR TYR B . n 
B 1 434 LYS 434 434 434 LYS LYS B . n 
B 1 435 ARG 435 435 435 ARG ARG B . n 
B 1 436 THR 436 436 436 THR THR B . n 
B 1 437 TYR 437 437 437 TYR TYR B . n 
B 1 438 TYR 438 438 438 TYR TYR B . n 
B 1 439 MET 439 439 439 MET MET B . n 
B 1 440 THR 440 440 440 THR THR B . n 
B 1 441 LYS 441 441 ?   ?   ?   B . n 
B 1 442 MET 442 442 ?   ?   ?   B . n 
B 1 443 GLY 443 443 ?   ?   ?   B . n 
B 1 444 VAL 444 444 ?   ?   ?   B . n 
B 1 445 ASP 445 445 ?   ?   ?   B . n 
B 1 446 VAL 446 446 ?   ?   ?   B . n 
B 1 447 VAL 447 447 ?   ?   ?   B . n 
B 1 448 SER 448 448 448 SER SER B . n 
B 1 449 ASP 449 449 449 ASP ASP B . n 
B 1 450 ASP 450 450 450 ASP ASP B . n 
B 1 451 PHE 451 451 451 PHE PHE B . n 
B 1 452 LEU 452 452 452 LEU LEU B . n 
B 1 453 ALA 453 453 453 ALA ALA B . n 
B 1 454 ASP 454 454 454 ASP ASP B . n 
B 1 455 GLN 455 455 455 GLN GLN B . n 
B 1 456 ALA 456 456 456 ALA ALA B . n 
B 1 457 ALA 457 457 457 ALA ALA B . n 
B 1 458 CYS 458 458 458 CYS CYS B . n 
B 1 459 TYR 459 459 459 TYR TYR B . n 
B 1 460 VAL 460 460 460 VAL VAL B . n 
B 1 461 GLN 461 461 461 GLN GLN B . n 
B 1 462 ALA 462 462 462 ALA ALA B . n 
B 1 463 ILE 463 463 463 ILE ILE B . n 
B 1 464 GLN 464 464 464 GLN GLN B . n 
B 1 465 TRP 465 465 465 TRP TRP B . n 
B 1 466 ILE 466 466 466 ILE ILE B . n 
B 1 467 LEU 467 467 467 LEU LEU B . n 
B 1 468 HIS 468 468 468 HIS HIS B . n 
B 1 469 TYR 469 469 469 TYR TYR B . n 
B 1 470 TYR 470 470 470 TYR TYR B . n 
B 1 471 TYR 471 471 471 TYR TYR B . n 
B 1 472 HIS 472 472 472 HIS HIS B . n 
B 1 473 GLY 473 473 473 GLY GLY B . n 
B 1 474 VAL 474 474 474 VAL VAL B . n 
B 1 475 GLN 475 475 475 GLN GLN B . n 
B 1 476 SER 476 476 476 SER SER B . n 
B 1 477 TRP 477 477 477 TRP TRP B . n 
B 1 478 SER 478 478 478 SER SER B . n 
B 1 479 TRP 479 479 479 TRP TRP B . n 
B 1 480 TYR 480 480 480 TYR TYR B . n 
B 1 481 TYR 481 481 481 TYR TYR B . n 
B 1 482 PRO 482 482 482 PRO PRO B . n 
B 1 483 TYR 483 483 483 TYR TYR B . n 
B 1 484 HIS 484 484 484 HIS HIS B . n 
B 1 485 TYR 485 485 485 TYR TYR B . n 
B 1 486 ALA 486 486 486 ALA ALA B . n 
B 1 487 PRO 487 487 487 PRO PRO B . n 
B 1 488 PHE 488 488 488 PHE PHE B . n 
B 1 489 LEU 489 489 489 LEU LEU B . n 
B 1 490 SER 490 490 490 SER SER B . n 
B 1 491 ASP 491 491 491 ASP ASP B . n 
B 1 492 ILE 492 492 492 ILE ILE B . n 
B 1 493 HIS 493 493 493 HIS HIS B . n 
B 1 494 ASN 494 494 494 ASN ASN B . n 
B 1 495 ILE 495 495 495 ILE ILE B . n 
B 1 496 SER 496 496 496 SER SER B . n 
B 1 497 THR 497 497 497 THR THR B . n 
B 1 498 LEU 498 498 498 LEU LEU B . n 
B 1 499 LYS 499 499 499 LYS LYS B . n 
B 1 500 ILE 500 500 500 ILE ILE B . n 
B 1 501 HIS 501 501 501 HIS HIS B . n 
B 1 502 PHE 502 502 502 PHE PHE B . n 
B 1 503 GLU 503 503 503 GLU GLU B . n 
B 1 504 LEU 504 504 504 LEU LEU B . n 
B 1 505 GLY 505 505 505 GLY GLY B . n 
B 1 506 LYS 506 506 506 LYS LYS B . n 
B 1 507 PRO 507 507 507 PRO PRO B . n 
B 1 508 PHE 508 508 508 PHE PHE B . n 
B 1 509 LYS 509 509 509 LYS LYS B . n 
B 1 510 PRO 510 510 510 PRO PRO B . n 
B 1 511 PHE 511 511 511 PHE PHE B . n 
B 1 512 GLU 512 512 512 GLU GLU B . n 
B 1 513 GLN 513 513 513 GLN GLN B . n 
B 1 514 LEU 514 514 514 LEU LEU B . n 
B 1 515 LEU 515 515 515 LEU LEU B . n 
B 1 516 ALA 516 516 516 ALA ALA B . n 
B 1 517 VAL 517 517 517 VAL VAL B . n 
B 1 518 LEU 518 518 518 LEU LEU B . n 
B 1 519 PRO 519 519 519 PRO PRO B . n 
B 1 520 ALA 520 520 520 ALA ALA B . n 
B 1 521 ALA 521 521 521 ALA ALA B . n 
B 1 522 SER 522 522 522 SER SER B . n 
B 1 523 LYS 523 523 523 LYS LYS B . n 
B 1 524 ASN 524 524 524 ASN ASN B . n 
B 1 525 LEU 525 525 525 LEU LEU B . n 
B 1 526 LEU 526 526 526 LEU LEU B . n 
B 1 527 PRO 527 527 527 PRO PRO B . n 
B 1 528 ALA 528 528 528 ALA ALA B . n 
B 1 529 CYS 529 529 529 CYS CYS B . n 
B 1 530 TYR 530 530 530 TYR TYR B . n 
B 1 531 GLN 531 531 531 GLN GLN B . n 
B 1 532 HIS 532 532 532 HIS HIS B . n 
B 1 533 LEU 533 533 533 LEU LEU B . n 
B 1 534 MET 534 534 534 MET MET B . n 
B 1 535 THR 535 535 535 THR THR B . n 
B 1 536 ASN 536 536 536 ASN ASN B . n 
B 1 537 GLU 537 537 537 GLU GLU B . n 
B 1 538 ASP 538 538 538 ASP ASP B . n 
B 1 539 SER 539 539 539 SER SER B . n 
B 1 540 PRO 540 540 540 PRO PRO B . n 
B 1 541 ILE 541 541 541 ILE ILE B . n 
B 1 542 ILE 542 542 542 ILE ILE B . n 
B 1 543 GLU 543 543 543 GLU GLU B . n 
B 1 544 TYR 544 544 544 TYR TYR B . n 
B 1 545 TYR 545 545 545 TYR TYR B . n 
B 1 546 PRO 546 546 546 PRO PRO B . n 
B 1 547 PRO 547 547 547 PRO PRO B . n 
B 1 548 ASP 548 548 548 ASP ASP B . n 
B 1 549 PHE 549 549 549 PHE PHE B . n 
B 1 550 LYS 550 550 550 LYS LYS B . n 
B 1 551 THR 551 551 551 THR THR B . n 
B 1 552 ASP 552 552 552 ASP ASP B . n 
B 1 553 LEU 553 553 ?   ?   ?   B . n 
B 1 554 ASN 554 554 ?   ?   ?   B . n 
B 1 555 GLY 555 555 ?   ?   ?   B . n 
B 1 556 LYS 556 556 ?   ?   ?   B . n 
B 1 557 GLN 557 557 ?   ?   ?   B . n 
B 1 558 GLN 558 558 ?   ?   ?   B . n 
B 1 559 GLU 559 559 ?   ?   ?   B . n 
B 1 560 TRP 560 560 ?   ?   ?   B . n 
B 1 561 GLU 561 561 ?   ?   ?   B . n 
B 1 562 ALA 562 562 562 ALA ALA B . n 
B 1 563 VAL 563 563 563 VAL VAL B . n 
B 1 564 VAL 564 564 564 VAL VAL B . n 
B 1 565 LEU 565 565 565 LEU LEU B . n 
B 1 566 ILE 566 566 566 ILE ILE B . n 
B 1 567 PRO 567 567 567 PRO PRO B . n 
B 1 568 PHE 568 568 568 PHE PHE B . n 
B 1 569 ILE 569 569 569 ILE ILE B . n 
B 1 570 ASP 570 570 570 ASP ASP B . n 
B 1 571 GLU 571 571 571 GLU GLU B . n 
B 1 572 LYS 572 572 572 LYS LYS B . n 
B 1 573 ARG 573 573 573 ARG ARG B . n 
B 1 574 LEU 574 574 574 LEU LEU B . n 
B 1 575 LEU 575 575 575 LEU LEU B . n 
B 1 576 GLU 576 576 576 GLU GLU B . n 
B 1 577 ALA 577 577 577 ALA ALA B . n 
B 1 578 MET 578 578 578 MET MET B . n 
B 1 579 GLU 579 579 579 GLU GLU B . n 
B 1 580 THR 580 580 580 THR THR B . n 
B 1 581 CYS 581 581 581 CYS CYS B . n 
B 1 582 ASN 582 582 582 ASN ASN B . n 
B 1 583 HIS 583 583 583 HIS HIS B . n 
B 1 584 SER 584 584 584 SER SER B . n 
B 1 585 LEU 585 585 585 LEU LEU B . n 
B 1 586 LYS 586 586 586 LYS LYS B . n 
B 1 587 LYS 587 587 587 LYS LYS B . n 
B 1 588 GLU 588 588 588 GLU GLU B . n 
B 1 589 GLU 589 589 589 GLU GLU B . n 
B 1 590 ARG 590 590 590 ARG ARG B . n 
B 1 591 LYS 591 591 591 LYS LYS B . n 
B 1 592 ARG 592 592 592 ARG ARG B . n 
B 1 593 ASN 593 593 593 ASN ASN B . n 
B 1 594 GLN 594 594 594 GLN GLN B . n 
B 1 595 HIS 595 595 595 HIS HIS B . n 
B 1 596 SER 596 596 596 SER SER B . n 
B 1 597 GLU 597 597 597 GLU GLU B . n 
B 1 598 CYS 598 598 598 CYS CYS B . n 
B 1 599 LEU 599 599 599 LEU LEU B . n 
B 1 600 MET 600 600 600 MET MET B . n 
B 1 601 CYS 601 601 601 CYS CYS B . n 
B 1 602 TRP 602 602 602 TRP TRP B . n 
B 1 603 TYR 603 603 603 TYR TYR B . n 
B 1 604 ASP 604 604 604 ASP ASP B . n 
B 1 605 ARG 605 605 605 ARG ARG B . n 
B 1 606 ASP 606 606 606 ASP ASP B . n 
B 1 607 THR 607 607 607 THR THR B . n 
B 1 608 GLU 608 608 608 GLU GLU B . n 
B 1 609 PHE 609 609 609 PHE PHE B . n 
B 1 610 ILE 610 610 610 ILE ILE B . n 
B 1 611 TYR 611 611 611 TYR TYR B . n 
B 1 612 PRO 612 612 612 PRO PRO B . n 
B 1 613 SER 613 613 613 SER SER B . n 
B 1 614 PRO 614 614 614 PRO PRO B . n 
B 1 615 TRP 615 615 615 TRP TRP B . n 
B 1 616 PRO 616 616 616 PRO PRO B . n 
B 1 617 GLU 617 617 617 GLU GLU B . n 
B 1 618 LYS 618 618 618 LYS LYS B . n 
B 1 619 PHE 619 619 619 PHE PHE B . n 
B 1 620 PRO 620 620 620 PRO PRO B . n 
B 1 621 ALA 621 621 621 ALA ALA B . n 
B 1 622 ILE 622 622 622 ILE ILE B . n 
B 1 623 GLU 623 623 623 GLU GLU B . n 
B 1 624 ARG 624 624 624 ARG ARG B . n 
B 1 625 CYS 625 625 625 CYS CYS B . n 
B 1 626 CYS 626 626 626 CYS CYS B . n 
B 1 627 THR 627 627 627 THR THR B . n 
B 1 628 ARG 628 628 628 ARG ARG B . n 
B 1 629 TYR 629 629 629 TYR TYR B . n 
B 1 630 LYS 630 630 630 LYS LYS B . n 
B 1 631 ILE 631 631 631 ILE ILE B . n 
B 1 632 ILE 632 632 632 ILE ILE B . n 
B 1 633 SER 633 633 633 SER SER B . n 
B 1 634 LEU 634 634 634 LEU LEU B . n 
B 1 635 ASP 635 635 635 ASP ASP B . n 
B 1 636 ALA 636 636 636 ALA ALA B . n 
B 1 637 TRP 637 637 637 TRP TRP B . n 
B 1 638 ARG 638 638 638 ARG ARG B . n 
B 1 639 VAL 639 639 639 VAL VAL B . n 
B 1 640 ASP 640 640 640 ASP ASP B . n 
B 1 641 ILE 641 641 641 ILE ILE B . n 
B 1 642 ASN 642 642 ?   ?   ?   B . n 
B 1 643 LYS 643 643 ?   ?   ?   B . n 
B 1 644 ASN 644 644 ?   ?   ?   B . n 
B 1 645 LYS 645 645 ?   ?   ?   B . n 
B 1 646 ILE 646 646 ?   ?   ?   B . n 
B 1 647 THR 647 647 ?   ?   ?   B . n 
B 1 648 ARG 648 648 ?   ?   ?   B . n 
B 1 649 ILE 649 649 ?   ?   ?   B . n 
B 1 650 ASP 650 650 ?   ?   ?   B . n 
B 1 651 GLN 651 651 ?   ?   ?   B . n 
B 1 652 LYS 652 652 ?   ?   ?   B . n 
B 1 653 ALA 653 653 ?   ?   ?   B . n 
B 1 654 ASP 654 654 ?   ?   ?   B . n 
B 1 655 TYR 655 655 ?   ?   ?   B . n 
B 1 656 LYS 656 656 ?   ?   ?   B . n 
B 1 657 ASP 657 657 ?   ?   ?   B . n 
B 1 658 ASP 658 658 ?   ?   ?   B . n 
B 1 659 ASP 659 659 ?   ?   ?   B . n 
B 1 660 ASP 660 660 ?   ?   ?   B . n 
B 1 661 LYS 661 661 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A3P 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A3P 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 A3P 1   701  701  A3P A3P A . 
D 3 MG  1   702  702  MG  MG  A . 
E 3 MG  1   703  703  MG  MG  A . 
F 4 EDO 1   704  704  EDO EDO A . 
G 4 EDO 1   705  705  EDO EDO A . 
H 4 EDO 1   706  706  EDO EDO A . 
I 4 EDO 1   707  707  EDO EDO A . 
J 4 EDO 1   708  708  EDO EDO A . 
K 4 EDO 1   709  709  EDO EDO A . 
L 4 EDO 1   710  710  EDO EDO A . 
M 4 EDO 1   711  711  EDO EDO A . 
N 4 EDO 1   712  712  EDO EDO A . 
O 4 EDO 1   713  713  EDO EDO A . 
P 4 EDO 1   714  714  EDO EDO A . 
Q 4 EDO 1   715  715  EDO EDO A . 
R 4 EDO 1   716  716  EDO EDO A . 
S 4 EDO 1   717  717  EDO EDO A . 
T 5 CL  1   718  719  CL  CL  A . 
U 6 PEG 1   719  720  PEG PEG A . 
V 4 EDO 1   701  701  EDO EDO B . 
W 4 EDO 1   702  702  EDO EDO B . 
X 7 HOH 1   801  802  HOH HOH A . 
X 7 HOH 2   802  801  HOH HOH A . 
X 7 HOH 3   803  803  HOH HOH A . 
X 7 HOH 4   804  804  HOH HOH A . 
X 7 HOH 5   805  807  HOH HOH A . 
X 7 HOH 6   806  814  HOH HOH A . 
X 7 HOH 7   807  810  HOH HOH A . 
X 7 HOH 8   808  811  HOH HOH A . 
X 7 HOH 9   809  806  HOH HOH A . 
X 7 HOH 10  810  899  HOH HOH A . 
X 7 HOH 11  811  830  HOH HOH A . 
X 7 HOH 12  812  816  HOH HOH A . 
X 7 HOH 13  813  809  HOH HOH A . 
X 7 HOH 14  814  819  HOH HOH A . 
X 7 HOH 15  815  851  HOH HOH A . 
X 7 HOH 16  816  805  HOH HOH A . 
X 7 HOH 17  817  817  HOH HOH A . 
X 7 HOH 18  818  813  HOH HOH A . 
X 7 HOH 19  819  822  HOH HOH A . 
X 7 HOH 20  820  823  HOH HOH A . 
X 7 HOH 21  821  843  HOH HOH A . 
X 7 HOH 22  822  818  HOH HOH A . 
X 7 HOH 23  823  833  HOH HOH A . 
X 7 HOH 24  824  850  HOH HOH A . 
X 7 HOH 25  825  824  HOH HOH A . 
X 7 HOH 26  826  883  HOH HOH A . 
X 7 HOH 27  827  827  HOH HOH A . 
X 7 HOH 28  828  820  HOH HOH A . 
X 7 HOH 29  829  859  HOH HOH A . 
X 7 HOH 30  830  838  HOH HOH A . 
X 7 HOH 31  831  815  HOH HOH A . 
X 7 HOH 32  832  821  HOH HOH A . 
X 7 HOH 33  833  835  HOH HOH A . 
X 7 HOH 34  834  831  HOH HOH A . 
X 7 HOH 35  835  856  HOH HOH A . 
X 7 HOH 36  836  870  HOH HOH A . 
X 7 HOH 37  837  847  HOH HOH A . 
X 7 HOH 38  838  837  HOH HOH A . 
X 7 HOH 39  839  877  HOH HOH A . 
X 7 HOH 40  840  834  HOH HOH A . 
X 7 HOH 41  841  841  HOH HOH A . 
X 7 HOH 42  842  889  HOH HOH A . 
X 7 HOH 43  843  826  HOH HOH A . 
X 7 HOH 44  844  904  HOH HOH A . 
X 7 HOH 45  845  849  HOH HOH A . 
X 7 HOH 46  846  844  HOH HOH A . 
X 7 HOH 47  847  846  HOH HOH A . 
X 7 HOH 48  848  864  HOH HOH A . 
X 7 HOH 49  849  829  HOH HOH A . 
X 7 HOH 50  850  854  HOH HOH A . 
X 7 HOH 51  851  911  HOH HOH A . 
X 7 HOH 52  852  848  HOH HOH A . 
X 7 HOH 53  853  860  HOH HOH A . 
X 7 HOH 54  854  852  HOH HOH A . 
X 7 HOH 55  855  888  HOH HOH A . 
X 7 HOH 56  856  872  HOH HOH A . 
X 7 HOH 57  857  825  HOH HOH A . 
X 7 HOH 58  858  863  HOH HOH A . 
X 7 HOH 59  859  865  HOH HOH A . 
X 7 HOH 60  860  900  HOH HOH A . 
X 7 HOH 61  861  867  HOH HOH A . 
X 7 HOH 62  862  855  HOH HOH A . 
X 7 HOH 63  863  839  HOH HOH A . 
X 7 HOH 64  864  907  HOH HOH A . 
X 7 HOH 65  865  878  HOH HOH A . 
X 7 HOH 66  866  869  HOH HOH A . 
X 7 HOH 67  867  832  HOH HOH A . 
X 7 HOH 68  868  836  HOH HOH A . 
X 7 HOH 69  869  842  HOH HOH A . 
X 7 HOH 70  870  954  HOH HOH A . 
X 7 HOH 71  871  840  HOH HOH A . 
X 7 HOH 72  872  890  HOH HOH A . 
X 7 HOH 73  873  876  HOH HOH A . 
X 7 HOH 74  874  853  HOH HOH A . 
X 7 HOH 75  875  884  HOH HOH A . 
X 7 HOH 76  876  875  HOH HOH A . 
X 7 HOH 77  877  858  HOH HOH A . 
X 7 HOH 78  878  874  HOH HOH A . 
X 7 HOH 79  879  845  HOH HOH A . 
X 7 HOH 80  880  909  HOH HOH A . 
X 7 HOH 81  881  886  HOH HOH A . 
X 7 HOH 82  882  897  HOH HOH A . 
X 7 HOH 83  883  1004 HOH HOH A . 
X 7 HOH 84  884  879  HOH HOH A . 
X 7 HOH 85  885  852  HOH HOH A . 
X 7 HOH 86  886  868  HOH HOH A . 
X 7 HOH 87  887  1012 HOH HOH A . 
X 7 HOH 88  888  808  HOH HOH A . 
X 7 HOH 89  889  873  HOH HOH A . 
X 7 HOH 90  890  929  HOH HOH A . 
X 7 HOH 91  891  935  HOH HOH A . 
X 7 HOH 92  892  905  HOH HOH A . 
X 7 HOH 93  893  947  HOH HOH A . 
X 7 HOH 94  894  871  HOH HOH A . 
X 7 HOH 95  895  924  HOH HOH A . 
X 7 HOH 96  896  908  HOH HOH A . 
X 7 HOH 97  897  955  HOH HOH A . 
X 7 HOH 98  898  913  HOH HOH A . 
X 7 HOH 99  899  992  HOH HOH A . 
X 7 HOH 100 900  862  HOH HOH A . 
X 7 HOH 101 901  910  HOH HOH A . 
X 7 HOH 102 902  828  HOH HOH A . 
X 7 HOH 103 903  885  HOH HOH A . 
X 7 HOH 104 904  974  HOH HOH A . 
X 7 HOH 105 905  857  HOH HOH A . 
X 7 HOH 106 906  893  HOH HOH A . 
X 7 HOH 107 907  1021 HOH HOH A . 
X 7 HOH 108 908  982  HOH HOH A . 
X 7 HOH 109 909  952  HOH HOH A . 
X 7 HOH 110 910  896  HOH HOH A . 
X 7 HOH 111 911  938  HOH HOH A . 
X 7 HOH 112 912  894  HOH HOH A . 
X 7 HOH 113 913  898  HOH HOH A . 
X 7 HOH 114 914  939  HOH HOH A . 
X 7 HOH 115 915  812  HOH HOH A . 
X 7 HOH 116 916  866  HOH HOH A . 
X 7 HOH 117 917  902  HOH HOH A . 
X 7 HOH 118 918  979  HOH HOH A . 
X 7 HOH 119 919  892  HOH HOH A . 
X 7 HOH 120 920  951  HOH HOH A . 
X 7 HOH 121 921  944  HOH HOH A . 
X 7 HOH 122 922  882  HOH HOH A . 
X 7 HOH 123 923  923  HOH HOH A . 
X 7 HOH 124 924  981  HOH HOH A . 
X 7 HOH 125 925  912  HOH HOH A . 
X 7 HOH 126 926  903  HOH HOH A . 
X 7 HOH 127 927  945  HOH HOH A . 
X 7 HOH 128 928  930  HOH HOH A . 
X 7 HOH 129 929  925  HOH HOH A . 
X 7 HOH 130 930  895  HOH HOH A . 
X 7 HOH 131 931  933  HOH HOH A . 
X 7 HOH 132 932  937  HOH HOH A . 
X 7 HOH 133 933  922  HOH HOH A . 
X 7 HOH 134 934  918  HOH HOH A . 
X 7 HOH 135 935  861  HOH HOH A . 
X 7 HOH 136 936  881  HOH HOH A . 
X 7 HOH 137 937  920  HOH HOH A . 
X 7 HOH 138 938  917  HOH HOH A . 
X 7 HOH 139 939  880  HOH HOH A . 
X 7 HOH 140 940  887  HOH HOH A . 
X 7 HOH 141 941  936  HOH HOH A . 
X 7 HOH 142 942  996  HOH HOH A . 
X 7 HOH 143 943  932  HOH HOH A . 
X 7 HOH 144 944  962  HOH HOH A . 
X 7 HOH 145 945  998  HOH HOH A . 
X 7 HOH 146 946  901  HOH HOH A . 
X 7 HOH 147 947  927  HOH HOH A . 
X 7 HOH 148 948  1026 HOH HOH A . 
X 7 HOH 149 949  1024 HOH HOH A . 
X 7 HOH 150 950  989  HOH HOH A . 
X 7 HOH 151 951  1041 HOH HOH A . 
X 7 HOH 152 952  891  HOH HOH A . 
X 7 HOH 153 953  934  HOH HOH A . 
X 7 HOH 154 954  946  HOH HOH A . 
X 7 HOH 155 955  926  HOH HOH A . 
X 7 HOH 156 956  943  HOH HOH A . 
X 7 HOH 157 957  956  HOH HOH A . 
X 7 HOH 158 958  953  HOH HOH A . 
X 7 HOH 159 959  950  HOH HOH A . 
X 7 HOH 160 960  928  HOH HOH A . 
X 7 HOH 161 961  906  HOH HOH A . 
X 7 HOH 162 962  916  HOH HOH A . 
X 7 HOH 163 963  973  HOH HOH A . 
X 7 HOH 164 964  1000 HOH HOH A . 
X 7 HOH 165 965  914  HOH HOH A . 
X 7 HOH 166 966  942  HOH HOH A . 
X 7 HOH 167 967  963  HOH HOH A . 
X 7 HOH 168 968  986  HOH HOH A . 
X 7 HOH 169 969  949  HOH HOH A . 
X 7 HOH 170 970  915  HOH HOH A . 
X 7 HOH 171 971  919  HOH HOH A . 
X 7 HOH 172 972  972  HOH HOH A . 
X 7 HOH 173 973  975  HOH HOH A . 
X 7 HOH 174 974  958  HOH HOH A . 
X 7 HOH 175 975  983  HOH HOH A . 
X 7 HOH 176 976  960  HOH HOH A . 
X 7 HOH 177 977  921  HOH HOH A . 
X 7 HOH 178 978  967  HOH HOH A . 
X 7 HOH 179 979  970  HOH HOH A . 
X 7 HOH 180 980  940  HOH HOH A . 
X 7 HOH 181 981  969  HOH HOH A . 
X 7 HOH 182 982  990  HOH HOH A . 
X 7 HOH 183 983  988  HOH HOH A . 
X 7 HOH 184 984  991  HOH HOH A . 
X 7 HOH 185 985  1023 HOH HOH A . 
X 7 HOH 186 986  1001 HOH HOH A . 
X 7 HOH 187 987  1065 HOH HOH A . 
X 7 HOH 188 988  978  HOH HOH A . 
X 7 HOH 189 989  1008 HOH HOH A . 
X 7 HOH 190 990  994  HOH HOH A . 
X 7 HOH 191 991  957  HOH HOH A . 
X 7 HOH 192 992  1015 HOH HOH A . 
X 7 HOH 193 993  984  HOH HOH A . 
X 7 HOH 194 994  961  HOH HOH A . 
X 7 HOH 195 995  985  HOH HOH A . 
X 7 HOH 196 996  980  HOH HOH A . 
X 7 HOH 197 997  1003 HOH HOH A . 
X 7 HOH 198 998  966  HOH HOH A . 
X 7 HOH 199 999  971  HOH HOH A . 
X 7 HOH 200 1000 964  HOH HOH A . 
X 7 HOH 201 1001 1103 HOH HOH A . 
X 7 HOH 202 1002 1016 HOH HOH A . 
X 7 HOH 203 1003 977  HOH HOH A . 
X 7 HOH 204 1004 1061 HOH HOH A . 
X 7 HOH 205 1005 941  HOH HOH A . 
X 7 HOH 206 1006 1017 HOH HOH A . 
X 7 HOH 207 1007 976  HOH HOH A . 
X 7 HOH 208 1008 1034 HOH HOH A . 
X 7 HOH 209 1009 1010 HOH HOH A . 
X 7 HOH 210 1010 1052 HOH HOH A . 
X 7 HOH 211 1011 1031 HOH HOH A . 
X 7 HOH 212 1012 1050 HOH HOH A . 
X 7 HOH 213 1013 993  HOH HOH A . 
X 7 HOH 214 1014 1037 HOH HOH A . 
X 7 HOH 215 1015 1028 HOH HOH A . 
X 7 HOH 216 1016 968  HOH HOH A . 
X 7 HOH 217 1017 1059 HOH HOH A . 
X 7 HOH 218 1018 1053 HOH HOH A . 
X 7 HOH 219 1019 987  HOH HOH A . 
X 7 HOH 220 1020 1064 HOH HOH A . 
X 7 HOH 221 1021 1046 HOH HOH A . 
X 7 HOH 222 1022 965  HOH HOH A . 
X 7 HOH 223 1023 1082 HOH HOH A . 
X 7 HOH 224 1024 1038 HOH HOH A . 
X 7 HOH 225 1025 1069 HOH HOH A . 
X 7 HOH 226 1026 1030 HOH HOH A . 
X 7 HOH 227 1027 1077 HOH HOH A . 
X 7 HOH 228 1028 1022 HOH HOH A . 
X 7 HOH 229 1029 997  HOH HOH A . 
X 7 HOH 230 1030 1042 HOH HOH A . 
X 7 HOH 231 1031 931  HOH HOH A . 
X 7 HOH 232 1032 1029 HOH HOH A . 
X 7 HOH 233 1033 1019 HOH HOH A . 
X 7 HOH 234 1034 1078 HOH HOH A . 
X 7 HOH 235 1035 1027 HOH HOH A . 
X 7 HOH 236 1036 1074 HOH HOH A . 
X 7 HOH 237 1037 1060 HOH HOH A . 
X 7 HOH 238 1038 1039 HOH HOH A . 
X 7 HOH 239 1039 1013 HOH HOH A . 
X 7 HOH 240 1040 1047 HOH HOH A . 
X 7 HOH 241 1041 1044 HOH HOH A . 
X 7 HOH 242 1042 1079 HOH HOH A . 
X 7 HOH 243 1043 1033 HOH HOH A . 
X 7 HOH 244 1044 1014 HOH HOH A . 
X 7 HOH 245 1045 1054 HOH HOH A . 
X 7 HOH 246 1046 1045 HOH HOH A . 
X 7 HOH 247 1047 1076 HOH HOH A . 
X 7 HOH 248 1048 1036 HOH HOH A . 
X 7 HOH 249 1049 1057 HOH HOH A . 
X 7 HOH 250 1050 1067 HOH HOH A . 
X 7 HOH 251 1051 1020 HOH HOH A . 
X 7 HOH 252 1052 1062 HOH HOH A . 
X 7 HOH 253 1053 1168 HOH HOH A . 
X 7 HOH 254 1054 995  HOH HOH A . 
X 7 HOH 255 1055 1002 HOH HOH A . 
X 7 HOH 256 1056 1095 HOH HOH A . 
X 7 HOH 257 1057 1009 HOH HOH A . 
X 7 HOH 258 1058 1098 HOH HOH A . 
X 7 HOH 259 1059 1058 HOH HOH A . 
X 7 HOH 260 1060 1006 HOH HOH A . 
X 7 HOH 261 1061 1068 HOH HOH A . 
X 7 HOH 262 1062 999  HOH HOH A . 
X 7 HOH 263 1063 1043 HOH HOH A . 
X 7 HOH 264 1064 1055 HOH HOH A . 
X 7 HOH 265 1065 1090 HOH HOH A . 
X 7 HOH 266 1066 1035 HOH HOH A . 
X 7 HOH 267 1067 1005 HOH HOH A . 
X 7 HOH 268 1068 1102 HOH HOH A . 
X 7 HOH 269 1069 1049 HOH HOH A . 
X 7 HOH 270 1070 1083 HOH HOH A . 
X 7 HOH 271 1071 1091 HOH HOH A . 
X 7 HOH 272 1072 1007 HOH HOH A . 
X 7 HOH 273 1073 1048 HOH HOH A . 
X 7 HOH 274 1074 1111 HOH HOH A . 
X 7 HOH 275 1075 1097 HOH HOH A . 
X 7 HOH 276 1076 1066 HOH HOH A . 
X 7 HOH 277 1077 1071 HOH HOH A . 
X 7 HOH 278 1078 1073 HOH HOH A . 
X 7 HOH 279 1079 1089 HOH HOH A . 
X 7 HOH 280 1080 1114 HOH HOH A . 
X 7 HOH 281 1081 1040 HOH HOH A . 
X 7 HOH 282 1082 1070 HOH HOH A . 
X 7 HOH 283 1083 948  HOH HOH A . 
X 7 HOH 284 1084 1117 HOH HOH A . 
X 7 HOH 285 1085 1085 HOH HOH A . 
X 7 HOH 286 1086 1025 HOH HOH A . 
X 7 HOH 287 1087 1056 HOH HOH A . 
X 7 HOH 288 1088 1147 HOH HOH A . 
X 7 HOH 289 1089 1100 HOH HOH A . 
X 7 HOH 290 1090 1086 HOH HOH A . 
X 7 HOH 291 1091 1105 HOH HOH A . 
X 7 HOH 292 1092 1032 HOH HOH A . 
X 7 HOH 293 1093 1084 HOH HOH A . 
X 7 HOH 294 1094 1011 HOH HOH A . 
X 7 HOH 295 1095 1146 HOH HOH A . 
X 7 HOH 296 1096 1072 HOH HOH A . 
X 7 HOH 297 1097 1118 HOH HOH A . 
X 7 HOH 298 1098 1075 HOH HOH A . 
X 7 HOH 299 1099 1137 HOH HOH A . 
X 7 HOH 300 1100 1088 HOH HOH A . 
X 7 HOH 301 1101 1119 HOH HOH A . 
X 7 HOH 302 1102 1063 HOH HOH A . 
X 7 HOH 303 1103 1121 HOH HOH A . 
X 7 HOH 304 1104 1313 HOH HOH A . 
X 7 HOH 305 1105 1115 HOH HOH A . 
X 7 HOH 306 1106 1092 HOH HOH A . 
X 7 HOH 307 1107 1080 HOH HOH A . 
X 7 HOH 308 1108 1099 HOH HOH A . 
X 7 HOH 309 1109 1142 HOH HOH A . 
X 7 HOH 310 1110 1129 HOH HOH A . 
X 7 HOH 311 1111 1136 HOH HOH A . 
X 7 HOH 312 1112 1106 HOH HOH A . 
X 7 HOH 313 1113 1124 HOH HOH A . 
X 7 HOH 314 1114 1101 HOH HOH A . 
X 7 HOH 315 1115 1125 HOH HOH A . 
X 7 HOH 316 1116 1096 HOH HOH A . 
X 7 HOH 317 1117 1134 HOH HOH A . 
X 7 HOH 318 1118 1104 HOH HOH A . 
X 7 HOH 319 1119 1110 HOH HOH A . 
X 7 HOH 320 1120 1018 HOH HOH A . 
X 7 HOH 321 1121 1120 HOH HOH A . 
X 7 HOH 322 1122 1109 HOH HOH A . 
X 7 HOH 323 1123 1112 HOH HOH A . 
X 7 HOH 324 1124 1107 HOH HOH A . 
X 7 HOH 325 1125 1128 HOH HOH A . 
X 7 HOH 326 1126 1143 HOH HOH A . 
X 7 HOH 327 1127 1116 HOH HOH A . 
X 7 HOH 328 1128 1131 HOH HOH A . 
X 7 HOH 329 1129 1132 HOH HOH A . 
X 7 HOH 330 1130 1133 HOH HOH A . 
X 7 HOH 331 1131 1138 HOH HOH A . 
X 7 HOH 332 1132 1144 HOH HOH A . 
X 7 HOH 333 1133 1093 HOH HOH A . 
X 7 HOH 334 1134 959  HOH HOH A . 
X 7 HOH 335 1135 1081 HOH HOH A . 
X 7 HOH 336 1136 1087 HOH HOH A . 
X 7 HOH 337 1137 1127 HOH HOH A . 
X 7 HOH 338 1138 1113 HOH HOH A . 
X 7 HOH 339 1139 1151 HOH HOH A . 
X 7 HOH 340 1140 1145 HOH HOH A . 
X 7 HOH 341 1141 1123 HOH HOH A . 
X 7 HOH 342 1142 1122 HOH HOH A . 
X 7 HOH 343 1143 1108 HOH HOH A . 
X 7 HOH 344 1144 1155 HOH HOH A . 
X 7 HOH 345 1145 1135 HOH HOH A . 
X 7 HOH 346 1146 1130 HOH HOH A . 
X 7 HOH 347 1147 1157 HOH HOH A . 
X 7 HOH 348 1148 1141 HOH HOH A . 
X 7 HOH 349 1149 1051 HOH HOH A . 
X 7 HOH 350 1150 1154 HOH HOH A . 
X 7 HOH 351 1151 1163 HOH HOH A . 
X 7 HOH 352 1152 1140 HOH HOH A . 
X 7 HOH 353 1153 1159 HOH HOH A . 
X 7 HOH 354 1154 1183 HOH HOH A . 
X 7 HOH 355 1155 1167 HOH HOH A . 
X 7 HOH 356 1156 1139 HOH HOH A . 
X 7 HOH 357 1157 1149 HOH HOH A . 
X 7 HOH 358 1158 1156 HOH HOH A . 
X 7 HOH 359 1159 1164 HOH HOH A . 
X 7 HOH 360 1160 1174 HOH HOH A . 
X 7 HOH 361 1161 1170 HOH HOH A . 
X 7 HOH 362 1162 1094 HOH HOH A . 
X 7 HOH 363 1163 1166 HOH HOH A . 
X 7 HOH 364 1164 1152 HOH HOH A . 
X 7 HOH 365 1165 1158 HOH HOH A . 
X 7 HOH 366 1166 1178 HOH HOH A . 
X 7 HOH 367 1167 1161 HOH HOH A . 
X 7 HOH 368 1168 1150 HOH HOH A . 
X 7 HOH 369 1169 1210 HOH HOH A . 
X 7 HOH 370 1170 1126 HOH HOH A . 
X 7 HOH 371 1171 1171 HOH HOH A . 
X 7 HOH 372 1172 1177 HOH HOH A . 
X 7 HOH 373 1173 1153 HOH HOH A . 
X 7 HOH 374 1174 1162 HOH HOH A . 
X 7 HOH 375 1175 1173 HOH HOH A . 
X 7 HOH 376 1176 1148 HOH HOH A . 
X 7 HOH 377 1177 1180 HOH HOH A . 
X 7 HOH 378 1178 1160 HOH HOH A . 
X 7 HOH 379 1179 1176 HOH HOH A . 
X 7 HOH 380 1180 1172 HOH HOH A . 
X 7 HOH 381 1181 1169 HOH HOH A . 
X 7 HOH 382 1182 1165 HOH HOH A . 
X 7 HOH 383 1183 1182 HOH HOH A . 
X 7 HOH 384 1184 1192 HOH HOH A . 
X 7 HOH 385 1185 1189 HOH HOH A . 
X 7 HOH 386 1186 1181 HOH HOH A . 
X 7 HOH 387 1187 1207 HOH HOH A . 
X 7 HOH 388 1188 1184 HOH HOH A . 
X 7 HOH 389 1189 1187 HOH HOH A . 
X 7 HOH 390 1190 1188 HOH HOH A . 
X 7 HOH 391 1191 1190 HOH HOH A . 
X 7 HOH 392 1192 1204 HOH HOH A . 
X 7 HOH 393 1193 1179 HOH HOH A . 
X 7 HOH 394 1194 1194 HOH HOH A . 
X 7 HOH 395 1195 1185 HOH HOH A . 
X 7 HOH 396 1196 1314 HOH HOH A . 
X 7 HOH 397 1197 1195 HOH HOH A . 
X 7 HOH 398 1198 1200 HOH HOH A . 
X 7 HOH 399 1199 1186 HOH HOH A . 
X 7 HOH 400 1200 1175 HOH HOH A . 
X 7 HOH 401 1201 1196 HOH HOH A . 
X 7 HOH 402 1202 1208 HOH HOH A . 
X 7 HOH 403 1203 1191 HOH HOH A . 
X 7 HOH 404 1204 1198 HOH HOH A . 
X 7 HOH 405 1205 1199 HOH HOH A . 
X 7 HOH 406 1206 1193 HOH HOH A . 
X 7 HOH 407 1207 1205 HOH HOH A . 
X 7 HOH 408 1208 1234 HOH HOH A . 
X 7 HOH 409 1209 1263 HOH HOH A . 
X 7 HOH 410 1210 1206 HOH HOH A . 
X 7 HOH 411 1211 1211 HOH HOH A . 
X 7 HOH 412 1212 1203 HOH HOH A . 
X 7 HOH 413 1213 1209 HOH HOH A . 
X 7 HOH 414 1214 1219 HOH HOH A . 
X 7 HOH 415 1215 1225 HOH HOH A . 
X 7 HOH 416 1216 1214 HOH HOH A . 
X 7 HOH 417 1217 1215 HOH HOH A . 
X 7 HOH 418 1218 1220 HOH HOH A . 
X 7 HOH 419 1219 1222 HOH HOH A . 
X 7 HOH 420 1220 1216 HOH HOH A . 
X 7 HOH 421 1221 1250 HOH HOH A . 
X 7 HOH 422 1222 1221 HOH HOH A . 
X 7 HOH 423 1223 1201 HOH HOH A . 
X 7 HOH 424 1224 1228 HOH HOH A . 
X 7 HOH 425 1225 1202 HOH HOH A . 
X 7 HOH 426 1226 1212 HOH HOH A . 
X 7 HOH 427 1227 1233 HOH HOH A . 
X 7 HOH 428 1228 1218 HOH HOH A . 
X 7 HOH 429 1229 1235 HOH HOH A . 
X 7 HOH 430 1230 1226 HOH HOH A . 
X 7 HOH 431 1231 1227 HOH HOH A . 
X 7 HOH 432 1232 1230 HOH HOH A . 
X 7 HOH 433 1233 1217 HOH HOH A . 
X 7 HOH 434 1234 1242 HOH HOH A . 
X 7 HOH 435 1235 1224 HOH HOH A . 
X 7 HOH 436 1236 1229 HOH HOH A . 
X 7 HOH 437 1237 1232 HOH HOH A . 
X 7 HOH 438 1238 1223 HOH HOH A . 
X 7 HOH 439 1239 1213 HOH HOH A . 
X 7 HOH 440 1240 1236 HOH HOH A . 
X 7 HOH 441 1241 1240 HOH HOH A . 
X 7 HOH 442 1242 1238 HOH HOH A . 
X 7 HOH 443 1243 1243 HOH HOH A . 
X 7 HOH 444 1244 1265 HOH HOH A . 
X 7 HOH 445 1245 1257 HOH HOH A . 
X 7 HOH 446 1246 1262 HOH HOH A . 
X 7 HOH 447 1247 1241 HOH HOH A . 
X 7 HOH 448 1248 1244 HOH HOH A . 
X 7 HOH 449 1249 1271 HOH HOH A . 
X 7 HOH 450 1250 1245 HOH HOH A . 
X 7 HOH 451 1251 1255 HOH HOH A . 
X 7 HOH 452 1252 1247 HOH HOH A . 
X 7 HOH 453 1253 1246 HOH HOH A . 
X 7 HOH 454 1254 1237 HOH HOH A . 
X 7 HOH 455 1255 1254 HOH HOH A . 
X 7 HOH 456 1256 1239 HOH HOH A . 
X 7 HOH 457 1257 1248 HOH HOH A . 
X 7 HOH 458 1258 1252 HOH HOH A . 
X 7 HOH 459 1259 1253 HOH HOH A . 
X 7 HOH 460 1260 1256 HOH HOH A . 
X 7 HOH 461 1261 1264 HOH HOH A . 
X 7 HOH 462 1262 1266 HOH HOH A . 
X 7 HOH 463 1263 1249 HOH HOH A . 
X 7 HOH 464 1264 1269 HOH HOH A . 
X 7 HOH 465 1265 1251 HOH HOH A . 
X 7 HOH 466 1266 1261 HOH HOH A . 
X 7 HOH 467 1267 1260 HOH HOH A . 
X 7 HOH 468 1268 1270 HOH HOH A . 
X 7 HOH 469 1269 1259 HOH HOH A . 
X 7 HOH 470 1270 1267 HOH HOH A . 
X 7 HOH 471 1271 1277 HOH HOH A . 
X 7 HOH 472 1272 1272 HOH HOH A . 
X 7 HOH 473 1273 1273 HOH HOH A . 
X 7 HOH 474 1274 1258 HOH HOH A . 
X 7 HOH 475 1275 1268 HOH HOH A . 
X 7 HOH 476 1276 1278 HOH HOH A . 
X 7 HOH 477 1277 1275 HOH HOH A . 
X 7 HOH 478 1278 1279 HOH HOH A . 
X 7 HOH 479 1279 1280 HOH HOH A . 
X 7 HOH 480 1280 1281 HOH HOH A . 
X 7 HOH 481 1281 1276 HOH HOH A . 
X 7 HOH 482 1282 1282 HOH HOH A . 
X 7 HOH 483 1283 1283 HOH HOH A . 
X 7 HOH 484 1284 1286 HOH HOH A . 
X 7 HOH 485 1285 1285 HOH HOH A . 
X 7 HOH 486 1286 1287 HOH HOH A . 
X 7 HOH 487 1287 1292 HOH HOH A . 
X 7 HOH 488 1288 1291 HOH HOH A . 
X 7 HOH 489 1289 1288 HOH HOH A . 
X 7 HOH 490 1290 1284 HOH HOH A . 
X 7 HOH 491 1291 1274 HOH HOH A . 
X 7 HOH 492 1292 1301 HOH HOH A . 
X 7 HOH 493 1293 1290 HOH HOH A . 
X 7 HOH 494 1294 1289 HOH HOH A . 
X 7 HOH 495 1295 1297 HOH HOH A . 
X 7 HOH 496 1296 1293 HOH HOH A . 
X 7 HOH 497 1297 1294 HOH HOH A . 
X 7 HOH 498 1298 1296 HOH HOH A . 
X 7 HOH 499 1299 1300 HOH HOH A . 
X 7 HOH 500 1300 1298 HOH HOH A . 
X 7 HOH 501 1301 1299 HOH HOH A . 
X 7 HOH 502 1302 1307 HOH HOH A . 
X 7 HOH 503 1303 1295 HOH HOH A . 
X 7 HOH 504 1304 1302 HOH HOH A . 
X 7 HOH 505 1305 1303 HOH HOH A . 
X 7 HOH 506 1306 1304 HOH HOH A . 
X 7 HOH 507 1307 1305 HOH HOH A . 
X 7 HOH 508 1308 1306 HOH HOH A . 
X 7 HOH 509 1309 1308 HOH HOH A . 
X 7 HOH 510 1310 1311 HOH HOH A . 
X 7 HOH 511 1311 1310 HOH HOH A . 
X 7 HOH 512 1312 1309 HOH HOH A . 
X 7 HOH 513 1313 1312 HOH HOH A . 
Y 7 HOH 1   801  801  HOH HOH B . 
Y 7 HOH 2   802  802  HOH HOH B . 
Y 7 HOH 3   803  803  HOH HOH B . 
Y 7 HOH 4   804  810  HOH HOH B . 
Y 7 HOH 5   805  805  HOH HOH B . 
Y 7 HOH 6   806  818  HOH HOH B . 
Y 7 HOH 7   807  806  HOH HOH B . 
Y 7 HOH 8   808  808  HOH HOH B . 
Y 7 HOH 9   809  809  HOH HOH B . 
Y 7 HOH 10  810  807  HOH HOH B . 
Y 7 HOH 11  811  804  HOH HOH B . 
Y 7 HOH 12  812  825  HOH HOH B . 
Y 7 HOH 13  813  816  HOH HOH B . 
Y 7 HOH 14  814  812  HOH HOH B . 
Y 7 HOH 15  815  847  HOH HOH B . 
Y 7 HOH 16  816  813  HOH HOH B . 
Y 7 HOH 17  817  827  HOH HOH B . 
Y 7 HOH 18  818  845  HOH HOH B . 
Y 7 HOH 19  819  836  HOH HOH B . 
Y 7 HOH 20  820  826  HOH HOH B . 
Y 7 HOH 21  821  823  HOH HOH B . 
Y 7 HOH 22  822  814  HOH HOH B . 
Y 7 HOH 23  823  879  HOH HOH B . 
Y 7 HOH 24  824  839  HOH HOH B . 
Y 7 HOH 25  825  885  HOH HOH B . 
Y 7 HOH 26  826  815  HOH HOH B . 
Y 7 HOH 27  827  820  HOH HOH B . 
Y 7 HOH 28  828  843  HOH HOH B . 
Y 7 HOH 29  829  857  HOH HOH B . 
Y 7 HOH 30  830  853  HOH HOH B . 
Y 7 HOH 31  831  828  HOH HOH B . 
Y 7 HOH 32  832  817  HOH HOH B . 
Y 7 HOH 33  833  858  HOH HOH B . 
Y 7 HOH 34  834  831  HOH HOH B . 
Y 7 HOH 35  835  874  HOH HOH B . 
Y 7 HOH 36  836  835  HOH HOH B . 
Y 7 HOH 37  837  822  HOH HOH B . 
Y 7 HOH 38  838  811  HOH HOH B . 
Y 7 HOH 39  839  884  HOH HOH B . 
Y 7 HOH 40  840  819  HOH HOH B . 
Y 7 HOH 41  841  842  HOH HOH B . 
Y 7 HOH 42  842  840  HOH HOH B . 
Y 7 HOH 43  843  876  HOH HOH B . 
Y 7 HOH 44  844  851  HOH HOH B . 
Y 7 HOH 45  845  871  HOH HOH B . 
Y 7 HOH 46  846  838  HOH HOH B . 
Y 7 HOH 47  847  844  HOH HOH B . 
Y 7 HOH 48  848  833  HOH HOH B . 
Y 7 HOH 49  849  860  HOH HOH B . 
Y 7 HOH 50  850  863  HOH HOH B . 
Y 7 HOH 51  851  850  HOH HOH B . 
Y 7 HOH 52  852  824  HOH HOH B . 
Y 7 HOH 53  853  841  HOH HOH B . 
Y 7 HOH 54  854  830  HOH HOH B . 
Y 7 HOH 55  855  859  HOH HOH B . 
Y 7 HOH 56  856  837  HOH HOH B . 
Y 7 HOH 57  857  890  HOH HOH B . 
Y 7 HOH 58  858  829  HOH HOH B . 
Y 7 HOH 59  859  865  HOH HOH B . 
Y 7 HOH 60  860  849  HOH HOH B . 
Y 7 HOH 61  861  866  HOH HOH B . 
Y 7 HOH 62  862  832  HOH HOH B . 
Y 7 HOH 63  863  861  HOH HOH B . 
Y 7 HOH 64  864  848  HOH HOH B . 
Y 7 HOH 65  865  855  HOH HOH B . 
Y 7 HOH 66  866  886  HOH HOH B . 
Y 7 HOH 67  867  864  HOH HOH B . 
Y 7 HOH 68  868  867  HOH HOH B . 
Y 7 HOH 69  869  834  HOH HOH B . 
Y 7 HOH 70  870  882  HOH HOH B . 
Y 7 HOH 71  871  846  HOH HOH B . 
Y 7 HOH 72  872  856  HOH HOH B . 
Y 7 HOH 73  873  889  HOH HOH B . 
Y 7 HOH 74  874  877  HOH HOH B . 
Y 7 HOH 75  875  910  HOH HOH B . 
Y 7 HOH 76  876  868  HOH HOH B . 
Y 7 HOH 77  877  972  HOH HOH B . 
Y 7 HOH 78  878  903  HOH HOH B . 
Y 7 HOH 79  879  888  HOH HOH B . 
Y 7 HOH 80  880  870  HOH HOH B . 
Y 7 HOH 81  881  880  HOH HOH B . 
Y 7 HOH 82  882  887  HOH HOH B . 
Y 7 HOH 83  883  878  HOH HOH B . 
Y 7 HOH 84  884  893  HOH HOH B . 
Y 7 HOH 85  885  869  HOH HOH B . 
Y 7 HOH 86  886  872  HOH HOH B . 
Y 7 HOH 87  887  892  HOH HOH B . 
Y 7 HOH 88  888  854  HOH HOH B . 
Y 7 HOH 89  889  901  HOH HOH B . 
Y 7 HOH 90  890  898  HOH HOH B . 
Y 7 HOH 91  891  912  HOH HOH B . 
Y 7 HOH 92  892  899  HOH HOH B . 
Y 7 HOH 93  893  925  HOH HOH B . 
Y 7 HOH 94  894  895  HOH HOH B . 
Y 7 HOH 95  895  915  HOH HOH B . 
Y 7 HOH 96  896  909  HOH HOH B . 
Y 7 HOH 97  897  881  HOH HOH B . 
Y 7 HOH 98  898  911  HOH HOH B . 
Y 7 HOH 99  899  919  HOH HOH B . 
Y 7 HOH 100 900  873  HOH HOH B . 
Y 7 HOH 101 901  930  HOH HOH B . 
Y 7 HOH 102 902  875  HOH HOH B . 
Y 7 HOH 103 903  923  HOH HOH B . 
Y 7 HOH 104 904  902  HOH HOH B . 
Y 7 HOH 105 905  897  HOH HOH B . 
Y 7 HOH 106 906  900  HOH HOH B . 
Y 7 HOH 107 907  928  HOH HOH B . 
Y 7 HOH 108 908  920  HOH HOH B . 
Y 7 HOH 109 909  931  HOH HOH B . 
Y 7 HOH 110 910  917  HOH HOH B . 
Y 7 HOH 111 911  905  HOH HOH B . 
Y 7 HOH 112 912  907  HOH HOH B . 
Y 7 HOH 113 913  904  HOH HOH B . 
Y 7 HOH 114 914  906  HOH HOH B . 
Y 7 HOH 115 915  929  HOH HOH B . 
Y 7 HOH 116 916  894  HOH HOH B . 
Y 7 HOH 117 917  924  HOH HOH B . 
Y 7 HOH 118 918  908  HOH HOH B . 
Y 7 HOH 119 919  891  HOH HOH B . 
Y 7 HOH 120 920  914  HOH HOH B . 
Y 7 HOH 121 921  896  HOH HOH B . 
Y 7 HOH 122 922  921  HOH HOH B . 
Y 7 HOH 123 923  913  HOH HOH B . 
Y 7 HOH 124 924  935  HOH HOH B . 
Y 7 HOH 125 925  937  HOH HOH B . 
Y 7 HOH 126 926  927  HOH HOH B . 
Y 7 HOH 127 927  916  HOH HOH B . 
Y 7 HOH 128 928  941  HOH HOH B . 
Y 7 HOH 129 929  922  HOH HOH B . 
Y 7 HOH 130 930  883  HOH HOH B . 
Y 7 HOH 131 931  946  HOH HOH B . 
Y 7 HOH 132 932  945  HOH HOH B . 
Y 7 HOH 133 933  948  HOH HOH B . 
Y 7 HOH 134 934  932  HOH HOH B . 
Y 7 HOH 135 935  821  HOH HOH B . 
Y 7 HOH 136 936  933  HOH HOH B . 
Y 7 HOH 137 937  957  HOH HOH B . 
Y 7 HOH 138 938  918  HOH HOH B . 
Y 7 HOH 139 939  950  HOH HOH B . 
Y 7 HOH 140 940  954  HOH HOH B . 
Y 7 HOH 141 941  947  HOH HOH B . 
Y 7 HOH 142 942  944  HOH HOH B . 
Y 7 HOH 143 943  939  HOH HOH B . 
Y 7 HOH 144 944  926  HOH HOH B . 
Y 7 HOH 145 945  958  HOH HOH B . 
Y 7 HOH 146 946  952  HOH HOH B . 
Y 7 HOH 147 947  934  HOH HOH B . 
Y 7 HOH 148 948  936  HOH HOH B . 
Y 7 HOH 149 949  943  HOH HOH B . 
Y 7 HOH 150 950  940  HOH HOH B . 
Y 7 HOH 151 951  942  HOH HOH B . 
Y 7 HOH 152 952  964  HOH HOH B . 
Y 7 HOH 153 953  955  HOH HOH B . 
Y 7 HOH 154 954  949  HOH HOH B . 
Y 7 HOH 155 955  969  HOH HOH B . 
Y 7 HOH 156 956  953  HOH HOH B . 
Y 7 HOH 157 957  962  HOH HOH B . 
Y 7 HOH 158 958  971  HOH HOH B . 
Y 7 HOH 159 959  959  HOH HOH B . 
Y 7 HOH 160 960  961  HOH HOH B . 
Y 7 HOH 161 961  951  HOH HOH B . 
Y 7 HOH 162 962  981  HOH HOH B . 
Y 7 HOH 163 963  968  HOH HOH B . 
Y 7 HOH 164 964  956  HOH HOH B . 
Y 7 HOH 165 965  965  HOH HOH B . 
Y 7 HOH 166 966  976  HOH HOH B . 
Y 7 HOH 167 967  970  HOH HOH B . 
Y 7 HOH 168 968  967  HOH HOH B . 
Y 7 HOH 169 969  973  HOH HOH B . 
Y 7 HOH 170 970  938  HOH HOH B . 
Y 7 HOH 171 971  979  HOH HOH B . 
Y 7 HOH 172 972  991  HOH HOH B . 
Y 7 HOH 173 973  977  HOH HOH B . 
Y 7 HOH 174 974  960  HOH HOH B . 
Y 7 HOH 175 975  966  HOH HOH B . 
Y 7 HOH 176 976  963  HOH HOH B . 
Y 7 HOH 177 977  975  HOH HOH B . 
Y 7 HOH 178 978  974  HOH HOH B . 
Y 7 HOH 179 979  984  HOH HOH B . 
Y 7 HOH 180 980  996  HOH HOH B . 
Y 7 HOH 181 981  982  HOH HOH B . 
Y 7 HOH 182 982  983  HOH HOH B . 
Y 7 HOH 183 983  994  HOH HOH B . 
Y 7 HOH 184 984  986  HOH HOH B . 
Y 7 HOH 185 985  998  HOH HOH B . 
Y 7 HOH 186 986  980  HOH HOH B . 
Y 7 HOH 187 987  978  HOH HOH B . 
Y 7 HOH 188 988  993  HOH HOH B . 
Y 7 HOH 189 989  989  HOH HOH B . 
Y 7 HOH 190 990  997  HOH HOH B . 
Y 7 HOH 191 991  990  HOH HOH B . 
Y 7 HOH 192 992  995  HOH HOH B . 
Y 7 HOH 193 993  992  HOH HOH B . 
Y 7 HOH 194 994  987  HOH HOH B . 
Y 7 HOH 195 995  988  HOH HOH B . 
Y 7 HOH 196 996  985  HOH HOH B . 
Y 7 HOH 197 997  999  HOH HOH B . 
Y 7 HOH 198 998  1000 HOH HOH B . 
Y 7 HOH 199 999  1001 HOH HOH B . 
Y 7 HOH 200 1000 1009 HOH HOH B . 
Y 7 HOH 201 1001 1008 HOH HOH B . 
Y 7 HOH 202 1002 1003 HOH HOH B . 
Y 7 HOH 203 1003 1011 HOH HOH B . 
Y 7 HOH 204 1004 1002 HOH HOH B . 
Y 7 HOH 205 1005 1005 HOH HOH B . 
Y 7 HOH 206 1006 1004 HOH HOH B . 
Y 7 HOH 207 1007 1010 HOH HOH B . 
Y 7 HOH 208 1008 1006 HOH HOH B . 
Y 7 HOH 209 1009 1007 HOH HOH B . 
Y 7 HOH 210 1010 1012 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        3 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot    ? ? ? .        4 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        5 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9E70 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     60.91 
_cell.length_a_esd                 ? 
_cell.length_b                     63.97 
_cell.length_b_esd                 ? 
_cell.length_c                     363.15 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9E70 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9E70 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.29 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.38 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.3 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Potassium fluoride, pH 7.3, 20% w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-07-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9E70 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.10 
_reflns.d_resolution_low                               48.051 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     84285 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.98 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.163 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.154 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.1 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5788 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.2 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.002 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            -0.013 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            0.015 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               44.990 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.958 
_refine.correlation_coeff_Fo_to_Fc_free          0.942 
_refine.details                                  'Hydrogens have not been used' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9E70 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.100 
_refine.ls_d_res_low                             48.051 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     84285 
_refine.ls_number_reflns_R_free                  4332 
_refine.ls_number_reflns_R_work                  79953 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.983 
_refine.ls_percent_reflns_R_free                 5.140 
_refine.ls_R_factor_all                          0.189 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2274 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1866 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.203 
_refine.pdbx_overall_ESU_R_Free                  0.173 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             5.088 
_refine.overall_SU_ML                            0.133 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.100 
_refine_hist.d_res_low                        48.051 
_refine_hist.number_atoms_solvent             723 
_refine_hist.number_atoms_total               10076 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        9252 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         101 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.012  9744  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 1.799  1.848  13179 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.547  5.000  1124  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 6.197  5.000  60    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.366 10.000 1664  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.574 10.000 499   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.127  0.200  1373  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  7511  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.223  0.200  4509  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.316  0.200  6477  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.172  0.200  696   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.228  0.200  87    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  35    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 4.040  4.171  4433  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.704  7.457  5533  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.545  4.710  5311  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.236  8.394  7631  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 10.637 45.839 15167 ? r_lrange_it                    ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.100 2.154  6123 . 335 5788 100.0000 . 0.260 . . 0.259 . . . . . 0.229 . 20 . 0.954 0.938 0.294 
'X-RAY DIFFRACTION' 2.154 2.213  5970 . 297 5673 100.0000 . 0.239 . . 0.236 . . . . . 0.205 . 20 . 0.961 0.939 0.297 
'X-RAY DIFFRACTION' 2.213 2.277  5818 . 294 5524 100.0000 . 0.224 . . 0.222 . . . . . 0.189 . 20 . 0.966 0.946 0.275 
'X-RAY DIFFRACTION' 2.277 2.347  5650 . 260 5390 100.0000 . 0.211 . . 0.209 . . . . . 0.179 . 20 . 0.970 0.958 0.251 
'X-RAY DIFFRACTION' 2.347 2.424  5486 . 280 5206 100.0000 . 0.209 . . 0.206 . . . . . 0.176 . 20 . 0.971 0.953 0.273 
'X-RAY DIFFRACTION' 2.424 2.509  5305 . 242 5063 100.0000 . 0.215 . . 0.212 . . . . . 0.179 . 20 . 0.971 0.955 0.268 
'X-RAY DIFFRACTION' 2.509 2.603  5133 . 276 4856 99.9805  . 0.199 . . 0.196 . . . . . 0.167 . 20 . 0.974 0.956 0.257 
'X-RAY DIFFRACTION' 2.603 2.709  4956 . 241 4715 100.0000 . 0.205 . . 0.201 . . . . . 0.172 . 20 . 0.973 0.949 0.289 
'X-RAY DIFFRACTION' 2.709 2.829  4765 . 253 4512 100.0000 . 0.207 . . 0.204 . . . . . 0.179 . 20 . 0.973 0.951 0.275 
'X-RAY DIFFRACTION' 2.829 2.967  4547 . 228 4319 100.0000 . 0.199 . . 0.195 . . . . . 0.173 . 20 . 0.975 0.952 0.272 
'X-RAY DIFFRACTION' 2.967 3.127  4356 . 207 4149 100.0000 . 0.189 . . 0.187 . . . . . 0.168 . 20 . 0.977 0.963 0.231 
'X-RAY DIFFRACTION' 3.127 3.316  4128 . 233 3895 100.0000 . 0.189 . . 0.187 . . . . . 0.172 . 20 . 0.978 0.963 0.233 
'X-RAY DIFFRACTION' 3.316 3.543  3931 . 212 3718 99.9746  . 0.186 . . 0.184 . . . . . 0.176 . 20 . 0.981 0.971 0.211 
'X-RAY DIFFRACTION' 3.543 3.826  3632 . 179 3453 100.0000 . 0.181 . . 0.179 . . . . . 0.175 . 20 . 0.983 0.966 0.231 
'X-RAY DIFFRACTION' 3.826 4.188  3349 . 166 3183 100.0000 . 0.155 . . 0.154 . . . . . 0.154 . 20 . 0.986 0.978 0.178 
'X-RAY DIFFRACTION' 4.188 4.678  3069 . 165 2904 100.0000 . 0.152 . . 0.150 . . . . . 0.154 . 20 . 0.986 0.977 0.194 
'X-RAY DIFFRACTION' 4.678 5.393  2704 . 142 2562 100.0000 . 0.151 . . 0.149 . . . . . 0.155 . 20 . 0.986 0.978 0.192 
'X-RAY DIFFRACTION' 5.393 6.584  2353 . 140 2213 100.0000 . 0.194 . . 0.192 . . . . . 0.197 . 20 . 0.983 0.976 0.220 
'X-RAY DIFFRACTION' 6.584 9.226  1868 . 113 1755 100.0000 . 0.184 . . 0.183 . . . . . 0.192 . 20 . 0.983 0.979 0.197 
'X-RAY DIFFRACTION' 9.226 48.051 1145 . 69  1075 99.9127  . 0.188 . . 0.191 . . . . . 0.228 . 20 . 0.973 0.986 0.153 
# 
_struct.entry_id                     9E70 
_struct.title                        
;Human XRN1 with Adenosine-3',5'-Bisphosphate (pAp) Bound
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9E70 
_struct_keywords.text            'Exonuclease, XRN1, pAp, Inhibitor, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 4 ? 
R N N 4 ? 
S N N 4 ? 
T N N 5 ? 
U N N 6 ? 
V N N 4 ? 
W N N 4 ? 
X N N 7 ? 
Y N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    XRN1_HUMAN 
_struct_ref.pdbx_db_accession          Q8IZH2 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKV
FFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKS
WQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPE
LGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWT
ALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEW
EAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVD
INKNKITRIDQKA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9E70 A 1 ? 653 ? Q8IZH2 1 ? 653 ? 1 653 
2 1 9E70 B 1 ? 653 ? Q8IZH2 1 ? 653 ? 1 653 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9E70 ASP A 654 ? UNP Q8IZH2 ? ? 'expression tag' 654 1  
1 9E70 TYR A 655 ? UNP Q8IZH2 ? ? 'expression tag' 655 2  
1 9E70 LYS A 656 ? UNP Q8IZH2 ? ? 'expression tag' 656 3  
1 9E70 ASP A 657 ? UNP Q8IZH2 ? ? 'expression tag' 657 4  
1 9E70 ASP A 658 ? UNP Q8IZH2 ? ? 'expression tag' 658 5  
1 9E70 ASP A 659 ? UNP Q8IZH2 ? ? 'expression tag' 659 6  
1 9E70 ASP A 660 ? UNP Q8IZH2 ? ? 'expression tag' 660 7  
1 9E70 LYS A 661 ? UNP Q8IZH2 ? ? 'expression tag' 661 8  
2 9E70 ASP B 654 ? UNP Q8IZH2 ? ? 'expression tag' 654 9  
2 9E70 TYR B 655 ? UNP Q8IZH2 ? ? 'expression tag' 655 10 
2 9E70 LYS B 656 ? UNP Q8IZH2 ? ? 'expression tag' 656 11 
2 9E70 ASP B 657 ? UNP Q8IZH2 ? ? 'expression tag' 657 12 
2 9E70 ASP B 658 ? UNP Q8IZH2 ? ? 'expression tag' 658 13 
2 9E70 ASP B 659 ? UNP Q8IZH2 ? ? 'expression tag' 659 14 
2 9E70 ASP B 660 ? UNP Q8IZH2 ? ? 'expression tag' 660 15 
2 9E70 LYS B 661 ? UNP Q8IZH2 ? ? 'expression tag' 661 16 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 4   ? TYR A 14  ? PRO A 4   TYR A 14  1 ? 11 
HELX_P HELX_P2  AA2 HIS A 24  ? ILE A 26  ? HIS A 24  ILE A 26  5 ? 3  
HELX_P HELX_P3  AA3 MET A 36  ? HIS A 45  ? MET A 36  HIS A 45  1 ? 10 
HELX_P HELX_P4  AA4 SER A 56  ? LYS A 76  ? SER A 56  LYS A 76  1 ? 21 
HELX_P HELX_P5  AA5 PRO A 90  ? ALA A 92  ? PRO A 90  ALA A 92  5 ? 3  
HELX_P HELX_P6  AA6 LYS A 93  ? LYS A 118 ? LYS A 93  LYS A 118 1 ? 26 
HELX_P HELX_P7  AA7 ASP A 129 ? ILE A 133 ? ASP A 129 ILE A 133 5 ? 5  
HELX_P HELX_P8  AA8 THR A 137 ? ASP A 158 ? THR A 137 ASP A 158 1 ? 22 
HELX_P HELX_P9  AA9 LYS A 159 ? GLN A 162 ? LYS A 159 GLN A 162 5 ? 4  
HELX_P HELX_P10 AB1 GLU A 176 ? ALA A 190 ? GLU A 176 ALA A 190 1 ? 15 
HELX_P HELX_P11 AB2 ASP A 206 ? SER A 216 ? ASP A 206 SER A 216 1 ? 11 
HELX_P HELX_P12 AB3 LEU A 251 ? PHE A 262 ? LEU A 251 PHE A 262 1 ? 12 
HELX_P HELX_P13 AB4 VAL A 264 ? ILE A 269 ? VAL A 264 ILE A 269 1 ? 6  
HELX_P HELX_P14 AB5 ASP A 274 ? PHE A 287 ? ASP A 274 PHE A 287 1 ? 14 
HELX_P HELX_P15 AB6 LEU A 288 ? GLY A 290 ? LEU A 288 GLY A 290 5 ? 3  
HELX_P HELX_P16 AB7 ASP A 305 ? LEU A 318 ? ASP A 305 LEU A 318 1 ? 14 
HELX_P HELX_P17 AB8 PRO A 319 ? LEU A 321 ? PRO A 319 LEU A 321 5 ? 3  
HELX_P HELX_P18 AB9 ASN A 332 ? SER A 344 ? ASN A 332 SER A 344 1 ? 13 
HELX_P HELX_P19 AC1 SER A 344 ? VAL A 354 ? SER A 344 VAL A 354 1 ? 11 
HELX_P HELX_P20 AC2 LEU A 425 ? MET A 442 ? LEU A 425 MET A 442 1 ? 18 
HELX_P HELX_P21 AC3 SER A 448 ? GLY A 473 ? SER A 448 GLY A 473 1 ? 26 
HELX_P HELX_P22 AC4 PHE A 488 ? ILE A 492 ? PHE A 488 ILE A 492 5 ? 5  
HELX_P HELX_P23 AC5 LYS A 509 ? LEU A 518 ? LYS A 509 LEU A 518 1 ? 10 
HELX_P HELX_P24 AC6 PRO A 519 ? LEU A 526 ? PRO A 519 LEU A 526 5 ? 8  
HELX_P HELX_P25 AC7 PRO A 527 ? ASN A 536 ? PRO A 527 ASN A 536 1 ? 10 
HELX_P HELX_P26 AC8 ILE A 541 ? TYR A 545 ? ILE A 541 TYR A 545 5 ? 5  
HELX_P HELX_P27 AC9 ASP A 570 ? THR A 580 ? ASP A 570 THR A 580 1 ? 11 
HELX_P HELX_P28 AD1 CYS A 581 ? LEU A 585 ? CYS A 581 LEU A 585 5 ? 5  
HELX_P HELX_P29 AD2 LYS A 586 ? ASN A 593 ? LYS A 586 ASN A 593 1 ? 8  
HELX_P HELX_P30 AD3 PRO B 4   ? TYR B 14  ? PRO B 4   TYR B 14  1 ? 11 
HELX_P HELX_P31 AD4 HIS B 24  ? ILE B 26  ? HIS B 24  ILE B 26  5 ? 3  
HELX_P HELX_P32 AD5 MET B 36  ? HIS B 45  ? MET B 36  HIS B 45  1 ? 10 
HELX_P HELX_P33 AD6 SER B 56  ? LYS B 76  ? SER B 56  LYS B 76  1 ? 21 
HELX_P HELX_P34 AD7 PRO B 90  ? LYS B 118 ? PRO B 90  LYS B 118 1 ? 29 
HELX_P HELX_P35 AD8 ASP B 129 ? ILE B 133 ? ASP B 129 ILE B 133 5 ? 5  
HELX_P HELX_P36 AD9 THR B 137 ? ASP B 158 ? THR B 137 ASP B 158 1 ? 22 
HELX_P HELX_P37 AE1 LYS B 159 ? GLN B 162 ? LYS B 159 GLN B 162 5 ? 4  
HELX_P HELX_P38 AE2 GLU B 176 ? LYS B 191 ? GLU B 176 LYS B 191 1 ? 16 
HELX_P HELX_P39 AE3 ASP B 206 ? SER B 216 ? ASP B 206 SER B 216 1 ? 11 
HELX_P HELX_P40 AE4 LEU B 251 ? SER B 263 ? LEU B 251 SER B 263 1 ? 13 
HELX_P HELX_P41 AE5 VAL B 264 ? LYS B 268 ? VAL B 264 LYS B 268 5 ? 5  
HELX_P HELX_P42 AE6 ASP B 274 ? GLY B 290 ? ASP B 274 GLY B 290 1 ? 17 
HELX_P HELX_P43 AE7 LEU B 297 ? HIS B 301 ? LEU B 297 HIS B 301 5 ? 5  
HELX_P HELX_P44 AE8 ASN B 303 ? ASP B 305 ? ASN B 303 ASP B 305 5 ? 3  
HELX_P HELX_P45 AE9 ALA B 306 ? GLY B 322 ? ALA B 306 GLY B 322 1 ? 17 
HELX_P HELX_P46 AF1 ASN B 332 ? SER B 344 ? ASN B 332 SER B 344 1 ? 13 
HELX_P HELX_P47 AF2 ASP B 345 ? LYS B 359 ? ASP B 345 LYS B 359 1 ? 15 
HELX_P HELX_P48 AF3 PHE B 426 ? MET B 439 ? PHE B 426 MET B 439 1 ? 14 
HELX_P HELX_P49 AF4 ASP B 449 ? HIS B 472 ? ASP B 449 HIS B 472 1 ? 24 
HELX_P HELX_P50 AF5 PHE B 488 ? ILE B 492 ? PHE B 488 ILE B 492 5 ? 5  
HELX_P HELX_P51 AF6 LYS B 509 ? LEU B 518 ? LYS B 509 LEU B 518 1 ? 10 
HELX_P HELX_P52 AF7 PRO B 519 ? LEU B 526 ? PRO B 519 LEU B 526 5 ? 8  
HELX_P HELX_P53 AF8 PRO B 527 ? ASN B 536 ? PRO B 527 ASN B 536 1 ? 10 
HELX_P HELX_P54 AF9 ILE B 541 ? TYR B 545 ? ILE B 541 TYR B 545 5 ? 5  
HELX_P HELX_P55 AG1 ASP B 570 ? THR B 580 ? ASP B 570 THR B 580 1 ? 11 
HELX_P HELX_P56 AG2 CYS B 581 ? LEU B 585 ? CYS B 581 LEU B 585 5 ? 5  
HELX_P HELX_P57 AG3 LYS B 586 ? ASN B 593 ? LYS B 586 ASN B 593 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A ASP 86  OD2 ? ? ? 1_555 D MG  . MG ? ? A ASP 86  A MG  702 1_555 ? ? ? ? ? ? ? 2.415 ? ? 
metalc2 metalc ? ? A GLU 176 OE1 ? ? ? 1_555 D MG  . MG ? ? A GLU 176 A MG  702 1_555 ? ? ? ? ? ? ? 2.393 ? ? 
metalc3 metalc ? ? A GLU 176 OE1 ? ? ? 1_555 E MG  . MG ? ? A GLU 176 A MG  703 1_555 ? ? ? ? ? ? ? 2.310 ? ? 
metalc4 metalc ? ? A GLU 178 OE1 ? ? ? 1_555 D MG  . MG ? ? A GLU 178 A MG  702 1_555 ? ? ? ? ? ? ? 2.332 ? ? 
metalc5 metalc ? ? A ASP 292 OD2 ? ? ? 1_555 E MG  . MG ? ? A ASP 292 A MG  703 1_555 ? ? ? ? ? ? ? 2.208 ? ? 
metalc6 metalc ? ? C A3P .   O2P A ? ? 1_555 D MG  . MG ? ? A A3P 701 A MG  702 1_555 ? ? ? ? ? ? ? 2.099 ? ? 
metalc7 metalc ? ? D MG  .   MG  ? ? ? 1_555 X HOH . O  B ? A MG  702 A HOH 915 1_555 ? ? ? ? ? ? ? 2.100 ? ? 
metalc8 metalc ? ? E MG  .   MG  ? ? ? 1_555 X HOH . O  ? ? A MG  703 A HOH 802 1_555 ? ? ? ? ? ? ? 2.124 ? ? 
metalc9 metalc ? ? E MG  .   MG  ? ? ? 1_555 X HOH . O  B ? A MG  703 A HOH 915 1_555 ? ? ? ? ? ? ? 2.947 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD2 ? A ASP 86  ? A ASP 86  ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 OE1 ? A GLU 176 ? A GLU 176 ? 1_555 128.1 ? 
2  OD2 ? A ASP 86  ? A ASP 86  ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 OE1 ? A GLU 178 ? A GLU 178 ? 1_555 114.0 ? 
3  OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 OE1 ? A GLU 178 ? A GLU 178 ? 1_555 98.4  ? 
4  OD2 ? A ASP 86  ? A ASP 86  ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O2P A C A3P .   ? A A3P 701 ? 1_555 88.2  ? 
5  OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O2P A C A3P .   ? A A3P 701 ? 1_555 142.4 ? 
6  OE1 ? A GLU 178 ? A GLU 178 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O2P A C A3P .   ? A A3P 701 ? 1_555 70.1  ? 
7  OD2 ? A ASP 86  ? A ASP 86  ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 147.7 ? 
8  OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 72.7  ? 
9  OE1 ? A GLU 178 ? A GLU 178 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 81.7  ? 
10 O2P A C A3P .   ? A A3P 701 ? 1_555 MG ? D MG . ? A MG 702 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 70.3  ? 
11 OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 OD2 ? A ASP 292 ? A ASP 292 ? 1_555 132.1 ? 
12 OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 O   ? X HOH .   ? A HOH 802 ? 1_555 113.7 ? 
13 OD2 ? A ASP 292 ? A ASP 292 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 O   ? X HOH .   ? A HOH 802 ? 1_555 71.8  ? 
14 OE1 ? A GLU 176 ? A GLU 176 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 59.7  ? 
15 OD2 ? A ASP 292 ? A ASP 292 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 102.5 ? 
16 O   ? X HOH .   ? A HOH 802 ? 1_555 MG ? E MG . ? A MG 703 ? 1_555 O   B X HOH .   ? A HOH 915 ? 1_555 54.5  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 9 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 9 ? 
AA6 ? 2 ? 
AA7 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? anti-parallel 
AA1 8 9 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? parallel      
AA5 4 5 ? parallel      
AA5 5 6 ? parallel      
AA5 6 7 ? parallel      
AA5 7 8 ? anti-parallel 
AA5 8 9 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 18  ? LYS A 22  ? SER A 18  LYS A 22  
AA1 2 THR A 245 ? HIS A 250 ? THR A 245 HIS A 250 
AA1 3 PHE A 221 ? GLU A 226 ? PHE A 221 GLU A 226 
AA1 4 HIS A 200 ? TYR A 203 ? HIS A 200 TYR A 203 
AA1 5 ASN A 31  ? ASP A 35  ? ASN A 31  ASP A 35  
AA1 6 VAL A 80  ? ALA A 84  ? VAL A 80  ALA A 84  
AA1 7 THR A 165 ? SER A 169 ? THR A 165 SER A 169 
AA1 8 LEU A 599 ? TYR A 603 ? LEU A 599 TYR A 603 
AA1 9 THR A 627 ? ILE A 631 ? THR A 627 ILE A 631 
AA2 1 ASN A 326 ? GLU A 327 ? ASN A 326 GLU A 327 
AA2 2 HIS A 330 ? LEU A 331 ? HIS A 330 LEU A 331 
AA3 1 LYS A 550 ? ASP A 552 ? LYS A 550 ASP A 552 
AA3 2 VAL A 563 ? LEU A 565 ? VAL A 563 LEU A 565 
AA4 1 PHE A 609 ? TYR A 611 ? PHE A 609 TYR A 611 
AA4 2 ILE A 622 ? CYS A 625 ? ILE A 622 CYS A 625 
AA5 1 GLU B 19  ? LYS B 22  ? GLU B 19  LYS B 22  
AA5 2 THR B 245 ? HIS B 250 ? THR B 245 HIS B 250 
AA5 3 HIS B 220 ? GLU B 226 ? HIS B 220 GLU B 226 
AA5 4 ARG B 199 ? TYR B 203 ? ARG B 199 TYR B 203 
AA5 5 ASN B 31  ? ASP B 35  ? ASN B 31  ASP B 35  
AA5 6 VAL B 80  ? ALA B 84  ? VAL B 80  ALA B 84  
AA5 7 THR B 165 ? SER B 169 ? THR B 165 SER B 169 
AA5 8 CYS B 598 ? TYR B 603 ? CYS B 598 TYR B 603 
AA5 9 THR B 627 ? ILE B 632 ? THR B 627 ILE B 632 
AA6 1 ASN B 326 ? GLU B 327 ? ASN B 326 GLU B 327 
AA6 2 HIS B 330 ? LEU B 331 ? HIS B 330 LEU B 331 
AA7 1 LYS B 550 ? THR B 551 ? LYS B 550 THR B 551 
AA7 2 VAL B 564 ? LEU B 565 ? VAL B 564 LEU B 565 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 21  ? N VAL A 21  O PHE A 246 ? O PHE A 246 
AA1 2 3 O LEU A 249 ? O LEU A 249 N LEU A 223 ? N LEU A 223 
AA1 3 4 O SER A 222 ? O SER A 222 N HIS A 200 ? N HIS A 200 
AA1 4 5 O CYS A 201 ? O CYS A 201 N TYR A 33  ? N TYR A 33  
AA1 5 6 N LEU A 32  ? N LEU A 32  O PHE A 82  ? O PHE A 82  
AA1 6 7 N MET A 83  ? N MET A 83  O TYR A 167 ? O TYR A 167 
AA1 7 8 N ILE A 166 ? N ILE A 166 O CYS A 601 ? O CYS A 601 
AA1 8 9 N TRP A 602 ? N TRP A 602 O ARG A 628 ? O ARG A 628 
AA2 1 2 N GLU A 327 ? N GLU A 327 O HIS A 330 ? O HIS A 330 
AA3 1 2 N ASP A 552 ? N ASP A 552 O VAL A 563 ? O VAL A 563 
AA4 1 2 N PHE A 609 ? N PHE A 609 O CYS A 625 ? O CYS A 625 
AA5 1 2 N VAL B 21  ? N VAL B 21  O PHE B 246 ? O PHE B 246 
AA5 2 3 O LEU B 249 ? O LEU B 249 N LEU B 223 ? N LEU B 223 
AA5 3 4 O HIS B 220 ? O HIS B 220 N HIS B 200 ? N HIS B 200 
AA5 4 5 O CYS B 201 ? O CYS B 201 N TYR B 33  ? N TYR B 33  
AA5 5 6 N LEU B 34  ? N LEU B 34  O ALA B 84  ? O ALA B 84  
AA5 6 7 N PHE B 81  ? N PHE B 81  O TYR B 167 ? O TYR B 167 
AA5 7 8 N ILE B 166 ? N ILE B 166 O CYS B 601 ? O CYS B 601 
AA5 8 9 N TRP B 602 ? N TRP B 602 O ARG B 628 ? O ARG B 628 
AA6 1 2 N GLU B 327 ? N GLU B 327 O HIS B 330 ? O HIS B 330 
AA7 1 2 N LYS B 550 ? N LYS B 550 O LEU B 565 ? O LEU B 565 
# 
_pdbx_entry_details.entry_id                   9E70 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   B HOH 969  ? ? O B HOH 978  ? ? 2.06 
2 1 O   A HOH 888  ? ? O A HOH 1204 ? ? 2.11 
3 1 O3P A A3P 701  ? A O A HOH 801  ? ? 2.11 
4 1 O   B ARG 624  ? ? O B HOH 801  ? ? 2.14 
5 1 O   A HOH 1093 ? ? O A HOH 1182 ? ? 2.19 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CG A MET 83  ? B SD A MET 83  ? B CE  A MET 83  ? B 86.29  100.20 -13.91 1.60 N 
2 1 CG A ARG 127 ? ? CD A ARG 127 ? ? NE  A ARG 127 ? ? 97.02  111.80 -14.78 2.10 N 
3 1 NE A ARG 624 ? ? CZ A ARG 624 ? ? NH1 A ARG 624 ? ? 123.62 120.30 3.32   0.50 N 
4 1 CG B MET 140 ? ? SD B MET 140 ? ? CE  B MET 140 ? ? 88.72  100.20 -11.48 1.60 N 
5 1 CB B TYR 629 ? ? CA B TYR 629 ? ? C   B TYR 629 ? ? 97.90  110.40 -12.50 2.00 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 291 ? ? -154.38 -158.80 
2  1 ASN A 303 ? ? -174.13 -161.23 
3  1 ASN A 494 ? ? 70.93   40.54   
4  1 ASN A 593 ? ? -90.39  57.00   
5  1 TRP A 615 ? ? -150.99 81.52   
6  1 CYS B 16  ? ? 72.16   -8.09   
7  1 PRO B 27  ? ? -62.52  -175.82 
8  1 GLU B 227 ? ? -75.24  -73.10  
9  1 ARG B 229 ? ? -69.43  70.60   
10 1 PHE B 293 ? ? -134.20 -71.66  
11 1 ASN B 303 ? ? -150.04 -152.79 
12 1 PRO B 482 ? ? -87.48  39.25   
13 1 ASN B 593 ? ? -85.55  39.99   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 127 ? ? 0.086 'SIDE CHAIN' 
2 1 ARG A 186 ? ? 0.074 'SIDE CHAIN' 
3 1 ARG B 91  ? ? 0.089 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A GLY 231 ? A GLY 231 
3   1 Y 1 A GLY 232 ? A GLY 232 
4   1 Y 1 A LYS 233 ? A LYS 233 
5   1 Y 1 A LYS 234 ? A LYS 234 
6   1 Y 1 A THR 235 ? A THR 235 
7   1 Y 1 A GLN 236 ? A GLN 236 
8   1 Y 1 A ARG 237 ? A ARG 237 
9   1 Y 1 A VAL 238 ? A VAL 238 
10  1 Y 1 A CYS 239 ? A CYS 239 
11  1 Y 1 A ALA 240 ? A ALA 240 
12  1 Y 1 A PRO 241 ? A PRO 241 
13  1 Y 1 A GLU 242 ? A GLU 242 
14  1 Y 1 A PHE 355 ? A PHE 355 
15  1 Y 1 A VAL 356 ? A VAL 356 
16  1 Y 1 A ASP 357 ? A ASP 357 
17  1 Y 1 A LEU 358 ? A LEU 358 
18  1 Y 1 A LYS 359 ? A LYS 359 
19  1 Y 1 A TRP 360 ? A TRP 360 
20  1 Y 1 A PHE 361 ? A PHE 361 
21  1 Y 1 A GLU 362 ? A GLU 362 
22  1 Y 1 A SER 363 ? A SER 363 
23  1 Y 1 A LYS 364 ? A LYS 364 
24  1 Y 1 A VAL 365 ? A VAL 365 
25  1 Y 1 A GLY 366 ? A GLY 366 
26  1 Y 1 A ASN 367 ? A ASN 367 
27  1 Y 1 A LYS 368 ? A LYS 368 
28  1 Y 1 A TYR 369 ? A TYR 369 
29  1 Y 1 A LEU 370 ? A LEU 370 
30  1 Y 1 A ASN 371 ? A ASN 371 
31  1 Y 1 A GLU 372 ? A GLU 372 
32  1 Y 1 A ALA 373 ? A ALA 373 
33  1 Y 1 A ALA 374 ? A ALA 374 
34  1 Y 1 A GLY 375 ? A GLY 375 
35  1 Y 1 A VAL 376 ? A VAL 376 
36  1 Y 1 A ALA 377 ? A ALA 377 
37  1 Y 1 A ALA 378 ? A ALA 378 
38  1 Y 1 A GLU 379 ? A GLU 379 
39  1 Y 1 A GLU 380 ? A GLU 380 
40  1 Y 1 A ALA 381 ? A ALA 381 
41  1 Y 1 A ARG 382 ? A ARG 382 
42  1 Y 1 A ASN 383 ? A ASN 383 
43  1 Y 1 A TYR 384 ? A TYR 384 
44  1 Y 1 A LYS 385 ? A LYS 385 
45  1 Y 1 A GLU 386 ? A GLU 386 
46  1 Y 1 A LYS 387 ? A LYS 387 
47  1 Y 1 A LYS 388 ? A LYS 388 
48  1 Y 1 A LYS 389 ? A LYS 389 
49  1 Y 1 A LEU 390 ? A LEU 390 
50  1 Y 1 A LYS 391 ? A LYS 391 
51  1 Y 1 A GLY 392 ? A GLY 392 
52  1 Y 1 A GLN 393 ? A GLN 393 
53  1 Y 1 A GLU 394 ? A GLU 394 
54  1 Y 1 A ASN 395 ? A ASN 395 
55  1 Y 1 A SER 396 ? A SER 396 
56  1 Y 1 A LEU 397 ? A LEU 397 
57  1 Y 1 A CYS 398 ? A CYS 398 
58  1 Y 1 A TRP 399 ? A TRP 399 
59  1 Y 1 A THR 400 ? A THR 400 
60  1 Y 1 A ALA 401 ? A ALA 401 
61  1 Y 1 A LEU 402 ? A LEU 402 
62  1 Y 1 A ASP 403 ? A ASP 403 
63  1 Y 1 A LYS 404 ? A LYS 404 
64  1 Y 1 A ASN 405 ? A ASN 405 
65  1 Y 1 A GLU 406 ? A GLU 406 
66  1 Y 1 A GLY 407 ? A GLY 407 
67  1 Y 1 A GLU 408 ? A GLU 408 
68  1 Y 1 A MET 409 ? A MET 409 
69  1 Y 1 A ILE 410 ? A ILE 410 
70  1 Y 1 A THR 411 ? A THR 411 
71  1 Y 1 A SER 412 ? A SER 412 
72  1 Y 1 A LYS 413 ? A LYS 413 
73  1 Y 1 A ASP 414 ? A ASP 414 
74  1 Y 1 A ASN 415 ? A ASN 415 
75  1 Y 1 A LEU 416 ? A LEU 416 
76  1 Y 1 A GLU 417 ? A GLU 417 
77  1 Y 1 A ASP 418 ? A ASP 418 
78  1 Y 1 A GLU 419 ? A GLU 419 
79  1 Y 1 A THR 420 ? A THR 420 
80  1 Y 1 A GLU 421 ? A GLU 421 
81  1 Y 1 A ASP 422 ? A ASP 422 
82  1 Y 1 A ASP 423 ? A ASP 423 
83  1 Y 1 A LYS 556 ? A LYS 556 
84  1 Y 1 A GLN 557 ? A GLN 557 
85  1 Y 1 A GLN 558 ? A GLN 558 
86  1 Y 1 A ASN 642 ? A ASN 642 
87  1 Y 1 A LYS 643 ? A LYS 643 
88  1 Y 1 A ASN 644 ? A ASN 644 
89  1 Y 1 A LYS 645 ? A LYS 645 
90  1 Y 1 A ILE 646 ? A ILE 646 
91  1 Y 1 A THR 647 ? A THR 647 
92  1 Y 1 A ARG 648 ? A ARG 648 
93  1 Y 1 A ILE 649 ? A ILE 649 
94  1 Y 1 A ASP 650 ? A ASP 650 
95  1 Y 1 A GLN 651 ? A GLN 651 
96  1 Y 1 A LYS 652 ? A LYS 652 
97  1 Y 1 A ALA 653 ? A ALA 653 
98  1 Y 1 A ASP 654 ? A ASP 654 
99  1 Y 1 A TYR 655 ? A TYR 655 
100 1 Y 1 A LYS 656 ? A LYS 656 
101 1 Y 1 A ASP 657 ? A ASP 657 
102 1 Y 1 A ASP 658 ? A ASP 658 
103 1 Y 1 A ASP 659 ? A ASP 659 
104 1 Y 1 A ASP 660 ? A ASP 660 
105 1 Y 1 A LYS 661 ? A LYS 661 
106 1 Y 1 B MET 1   ? B MET 1   
107 1 Y 1 B GLY 231 ? B GLY 231 
108 1 Y 1 B GLY 232 ? B GLY 232 
109 1 Y 1 B LYS 233 ? B LYS 233 
110 1 Y 1 B LYS 234 ? B LYS 234 
111 1 Y 1 B THR 235 ? B THR 235 
112 1 Y 1 B GLN 236 ? B GLN 236 
113 1 Y 1 B ARG 237 ? B ARG 237 
114 1 Y 1 B VAL 238 ? B VAL 238 
115 1 Y 1 B CYS 239 ? B CYS 239 
116 1 Y 1 B ALA 240 ? B ALA 240 
117 1 Y 1 B PRO 241 ? B PRO 241 
118 1 Y 1 B GLU 242 ? B GLU 242 
119 1 Y 1 B GLU 243 ? B GLU 243 
120 1 Y 1 B PHE 361 ? B PHE 361 
121 1 Y 1 B GLU 362 ? B GLU 362 
122 1 Y 1 B SER 363 ? B SER 363 
123 1 Y 1 B LYS 364 ? B LYS 364 
124 1 Y 1 B VAL 365 ? B VAL 365 
125 1 Y 1 B GLY 366 ? B GLY 366 
126 1 Y 1 B ASN 367 ? B ASN 367 
127 1 Y 1 B LYS 368 ? B LYS 368 
128 1 Y 1 B TYR 369 ? B TYR 369 
129 1 Y 1 B LEU 370 ? B LEU 370 
130 1 Y 1 B ASN 371 ? B ASN 371 
131 1 Y 1 B GLU 372 ? B GLU 372 
132 1 Y 1 B ALA 373 ? B ALA 373 
133 1 Y 1 B ALA 374 ? B ALA 374 
134 1 Y 1 B GLY 375 ? B GLY 375 
135 1 Y 1 B VAL 376 ? B VAL 376 
136 1 Y 1 B ALA 377 ? B ALA 377 
137 1 Y 1 B ALA 378 ? B ALA 378 
138 1 Y 1 B GLU 379 ? B GLU 379 
139 1 Y 1 B GLU 380 ? B GLU 380 
140 1 Y 1 B ALA 381 ? B ALA 381 
141 1 Y 1 B ARG 382 ? B ARG 382 
142 1 Y 1 B ASN 383 ? B ASN 383 
143 1 Y 1 B TYR 384 ? B TYR 384 
144 1 Y 1 B LYS 385 ? B LYS 385 
145 1 Y 1 B GLU 386 ? B GLU 386 
146 1 Y 1 B LYS 387 ? B LYS 387 
147 1 Y 1 B LYS 388 ? B LYS 388 
148 1 Y 1 B LYS 389 ? B LYS 389 
149 1 Y 1 B LEU 390 ? B LEU 390 
150 1 Y 1 B LYS 391 ? B LYS 391 
151 1 Y 1 B GLY 392 ? B GLY 392 
152 1 Y 1 B GLN 393 ? B GLN 393 
153 1 Y 1 B GLU 394 ? B GLU 394 
154 1 Y 1 B ASN 395 ? B ASN 395 
155 1 Y 1 B SER 396 ? B SER 396 
156 1 Y 1 B LEU 397 ? B LEU 397 
157 1 Y 1 B CYS 398 ? B CYS 398 
158 1 Y 1 B TRP 399 ? B TRP 399 
159 1 Y 1 B THR 400 ? B THR 400 
160 1 Y 1 B ALA 401 ? B ALA 401 
161 1 Y 1 B LEU 402 ? B LEU 402 
162 1 Y 1 B ASP 403 ? B ASP 403 
163 1 Y 1 B LYS 404 ? B LYS 404 
164 1 Y 1 B ASN 405 ? B ASN 405 
165 1 Y 1 B GLU 406 ? B GLU 406 
166 1 Y 1 B GLY 407 ? B GLY 407 
167 1 Y 1 B GLU 408 ? B GLU 408 
168 1 Y 1 B MET 409 ? B MET 409 
169 1 Y 1 B ILE 410 ? B ILE 410 
170 1 Y 1 B THR 411 ? B THR 411 
171 1 Y 1 B SER 412 ? B SER 412 
172 1 Y 1 B LYS 413 ? B LYS 413 
173 1 Y 1 B ASP 414 ? B ASP 414 
174 1 Y 1 B ASN 415 ? B ASN 415 
175 1 Y 1 B LEU 416 ? B LEU 416 
176 1 Y 1 B GLU 417 ? B GLU 417 
177 1 Y 1 B ASP 418 ? B ASP 418 
178 1 Y 1 B GLU 419 ? B GLU 419 
179 1 Y 1 B THR 420 ? B THR 420 
180 1 Y 1 B GLU 421 ? B GLU 421 
181 1 Y 1 B ASP 422 ? B ASP 422 
182 1 Y 1 B ASP 423 ? B ASP 423 
183 1 Y 1 B ASP 424 ? B ASP 424 
184 1 Y 1 B LYS 441 ? B LYS 441 
185 1 Y 1 B MET 442 ? B MET 442 
186 1 Y 1 B GLY 443 ? B GLY 443 
187 1 Y 1 B VAL 444 ? B VAL 444 
188 1 Y 1 B ASP 445 ? B ASP 445 
189 1 Y 1 B VAL 446 ? B VAL 446 
190 1 Y 1 B VAL 447 ? B VAL 447 
191 1 Y 1 B LEU 553 ? B LEU 553 
192 1 Y 1 B ASN 554 ? B ASN 554 
193 1 Y 1 B GLY 555 ? B GLY 555 
194 1 Y 1 B LYS 556 ? B LYS 556 
195 1 Y 1 B GLN 557 ? B GLN 557 
196 1 Y 1 B GLN 558 ? B GLN 558 
197 1 Y 1 B GLU 559 ? B GLU 559 
198 1 Y 1 B TRP 560 ? B TRP 560 
199 1 Y 1 B GLU 561 ? B GLU 561 
200 1 Y 1 B ASN 642 ? B ASN 642 
201 1 Y 1 B LYS 643 ? B LYS 643 
202 1 Y 1 B ASN 644 ? B ASN 644 
203 1 Y 1 B LYS 645 ? B LYS 645 
204 1 Y 1 B ILE 646 ? B ILE 646 
205 1 Y 1 B THR 647 ? B THR 647 
206 1 Y 1 B ARG 648 ? B ARG 648 
207 1 Y 1 B ILE 649 ? B ILE 649 
208 1 Y 1 B ASP 650 ? B ASP 650 
209 1 Y 1 B GLN 651 ? B GLN 651 
210 1 Y 1 B LYS 652 ? B LYS 652 
211 1 Y 1 B ALA 653 ? B ALA 653 
212 1 Y 1 B ASP 654 ? B ASP 654 
213 1 Y 1 B TYR 655 ? B TYR 655 
214 1 Y 1 B LYS 656 ? B LYS 656 
215 1 Y 1 B ASP 657 ? B ASP 657 
216 1 Y 1 B ASP 658 ? B ASP 658 
217 1 Y 1 B ASP 659 ? B ASP 659 
218 1 Y 1 B ASP 660 ? B ASP 660 
219 1 Y 1 B LYS 661 ? B LYS 661 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A3P P1     P  N N 1   
A3P O1P    O  N N 2   
A3P O2P    O  N N 3   
A3P O3P    O  N N 4   
A3P P2     P  N N 5   
A3P O4P    O  N N 6   
A3P O5P    O  N N 7   
A3P O6P    O  N N 8   
A3P "O5'"  O  N N 9   
A3P "C5'"  C  N N 10  
A3P "C4'"  C  N R 11  
A3P "O4'"  O  N N 12  
A3P "C3'"  C  N S 13  
A3P "O3'"  O  N N 14  
A3P "C2'"  C  N R 15  
A3P "O2'"  O  N N 16  
A3P "C1'"  C  N R 17  
A3P N9     N  Y N 18  
A3P C8     C  Y N 19  
A3P N7     N  Y N 20  
A3P C5     C  Y N 21  
A3P C6     C  Y N 22  
A3P N6     N  N N 23  
A3P N1     N  Y N 24  
A3P C2     C  Y N 25  
A3P N3     N  Y N 26  
A3P C4     C  Y N 27  
A3P HOP2   H  N N 28  
A3P HOP3   H  N N 29  
A3P HOP5   H  N N 30  
A3P HOP6   H  N N 31  
A3P "H5'1" H  N N 32  
A3P "H5'2" H  N N 33  
A3P "H4'"  H  N N 34  
A3P "H3'"  H  N N 35  
A3P "H2'"  H  N N 36  
A3P "HO2'" H  N N 37  
A3P "H1'"  H  N N 38  
A3P H8     H  N N 39  
A3P HN61   H  N N 40  
A3P HN62   H  N N 41  
A3P H2     H  N N 42  
ALA N      N  N N 43  
ALA CA     C  N S 44  
ALA C      C  N N 45  
ALA O      O  N N 46  
ALA CB     C  N N 47  
ALA OXT    O  N N 48  
ALA H      H  N N 49  
ALA H2     H  N N 50  
ALA HA     H  N N 51  
ALA HB1    H  N N 52  
ALA HB2    H  N N 53  
ALA HB3    H  N N 54  
ALA HXT    H  N N 55  
ARG N      N  N N 56  
ARG CA     C  N S 57  
ARG C      C  N N 58  
ARG O      O  N N 59  
ARG CB     C  N N 60  
ARG CG     C  N N 61  
ARG CD     C  N N 62  
ARG NE     N  N N 63  
ARG CZ     C  N N 64  
ARG NH1    N  N N 65  
ARG NH2    N  N N 66  
ARG OXT    O  N N 67  
ARG H      H  N N 68  
ARG H2     H  N N 69  
ARG HA     H  N N 70  
ARG HB2    H  N N 71  
ARG HB3    H  N N 72  
ARG HG2    H  N N 73  
ARG HG3    H  N N 74  
ARG HD2    H  N N 75  
ARG HD3    H  N N 76  
ARG HE     H  N N 77  
ARG HH11   H  N N 78  
ARG HH12   H  N N 79  
ARG HH21   H  N N 80  
ARG HH22   H  N N 81  
ARG HXT    H  N N 82  
ASN N      N  N N 83  
ASN CA     C  N S 84  
ASN C      C  N N 85  
ASN O      O  N N 86  
ASN CB     C  N N 87  
ASN CG     C  N N 88  
ASN OD1    O  N N 89  
ASN ND2    N  N N 90  
ASN OXT    O  N N 91  
ASN H      H  N N 92  
ASN H2     H  N N 93  
ASN HA     H  N N 94  
ASN HB2    H  N N 95  
ASN HB3    H  N N 96  
ASN HD21   H  N N 97  
ASN HD22   H  N N 98  
ASN HXT    H  N N 99  
ASP N      N  N N 100 
ASP CA     C  N S 101 
ASP C      C  N N 102 
ASP O      O  N N 103 
ASP CB     C  N N 104 
ASP CG     C  N N 105 
ASP OD1    O  N N 106 
ASP OD2    O  N N 107 
ASP OXT    O  N N 108 
ASP H      H  N N 109 
ASP H2     H  N N 110 
ASP HA     H  N N 111 
ASP HB2    H  N N 112 
ASP HB3    H  N N 113 
ASP HD2    H  N N 114 
ASP HXT    H  N N 115 
CL  CL     CL N N 116 
CYS N      N  N N 117 
CYS CA     C  N R 118 
CYS C      C  N N 119 
CYS O      O  N N 120 
CYS CB     C  N N 121 
CYS SG     S  N N 122 
CYS OXT    O  N N 123 
CYS H      H  N N 124 
CYS H2     H  N N 125 
CYS HA     H  N N 126 
CYS HB2    H  N N 127 
CYS HB3    H  N N 128 
CYS HG     H  N N 129 
CYS HXT    H  N N 130 
EDO C1     C  N N 131 
EDO O1     O  N N 132 
EDO C2     C  N N 133 
EDO O2     O  N N 134 
EDO H11    H  N N 135 
EDO H12    H  N N 136 
EDO HO1    H  N N 137 
EDO H21    H  N N 138 
EDO H22    H  N N 139 
EDO HO2    H  N N 140 
GLN N      N  N N 141 
GLN CA     C  N S 142 
GLN C      C  N N 143 
GLN O      O  N N 144 
GLN CB     C  N N 145 
GLN CG     C  N N 146 
GLN CD     C  N N 147 
GLN OE1    O  N N 148 
GLN NE2    N  N N 149 
GLN OXT    O  N N 150 
GLN H      H  N N 151 
GLN H2     H  N N 152 
GLN HA     H  N N 153 
GLN HB2    H  N N 154 
GLN HB3    H  N N 155 
GLN HG2    H  N N 156 
GLN HG3    H  N N 157 
GLN HE21   H  N N 158 
GLN HE22   H  N N 159 
GLN HXT    H  N N 160 
GLU N      N  N N 161 
GLU CA     C  N S 162 
GLU C      C  N N 163 
GLU O      O  N N 164 
GLU CB     C  N N 165 
GLU CG     C  N N 166 
GLU CD     C  N N 167 
GLU OE1    O  N N 168 
GLU OE2    O  N N 169 
GLU OXT    O  N N 170 
GLU H      H  N N 171 
GLU H2     H  N N 172 
GLU HA     H  N N 173 
GLU HB2    H  N N 174 
GLU HB3    H  N N 175 
GLU HG2    H  N N 176 
GLU HG3    H  N N 177 
GLU HE2    H  N N 178 
GLU HXT    H  N N 179 
GLY N      N  N N 180 
GLY CA     C  N N 181 
GLY C      C  N N 182 
GLY O      O  N N 183 
GLY OXT    O  N N 184 
GLY H      H  N N 185 
GLY H2     H  N N 186 
GLY HA2    H  N N 187 
GLY HA3    H  N N 188 
GLY HXT    H  N N 189 
HIS N      N  N N 190 
HIS CA     C  N S 191 
HIS C      C  N N 192 
HIS O      O  N N 193 
HIS CB     C  N N 194 
HIS CG     C  Y N 195 
HIS ND1    N  Y N 196 
HIS CD2    C  Y N 197 
HIS CE1    C  Y N 198 
HIS NE2    N  Y N 199 
HIS OXT    O  N N 200 
HIS H      H  N N 201 
HIS H2     H  N N 202 
HIS HA     H  N N 203 
HIS HB2    H  N N 204 
HIS HB3    H  N N 205 
HIS HD1    H  N N 206 
HIS HD2    H  N N 207 
HIS HE1    H  N N 208 
HIS HE2    H  N N 209 
HIS HXT    H  N N 210 
HOH O      O  N N 211 
HOH H1     H  N N 212 
HOH H2     H  N N 213 
ILE N      N  N N 214 
ILE CA     C  N S 215 
ILE C      C  N N 216 
ILE O      O  N N 217 
ILE CB     C  N S 218 
ILE CG1    C  N N 219 
ILE CG2    C  N N 220 
ILE CD1    C  N N 221 
ILE OXT    O  N N 222 
ILE H      H  N N 223 
ILE H2     H  N N 224 
ILE HA     H  N N 225 
ILE HB     H  N N 226 
ILE HG12   H  N N 227 
ILE HG13   H  N N 228 
ILE HG21   H  N N 229 
ILE HG22   H  N N 230 
ILE HG23   H  N N 231 
ILE HD11   H  N N 232 
ILE HD12   H  N N 233 
ILE HD13   H  N N 234 
ILE HXT    H  N N 235 
LEU N      N  N N 236 
LEU CA     C  N S 237 
LEU C      C  N N 238 
LEU O      O  N N 239 
LEU CB     C  N N 240 
LEU CG     C  N N 241 
LEU CD1    C  N N 242 
LEU CD2    C  N N 243 
LEU OXT    O  N N 244 
LEU H      H  N N 245 
LEU H2     H  N N 246 
LEU HA     H  N N 247 
LEU HB2    H  N N 248 
LEU HB3    H  N N 249 
LEU HG     H  N N 250 
LEU HD11   H  N N 251 
LEU HD12   H  N N 252 
LEU HD13   H  N N 253 
LEU HD21   H  N N 254 
LEU HD22   H  N N 255 
LEU HD23   H  N N 256 
LEU HXT    H  N N 257 
LYS N      N  N N 258 
LYS CA     C  N S 259 
LYS C      C  N N 260 
LYS O      O  N N 261 
LYS CB     C  N N 262 
LYS CG     C  N N 263 
LYS CD     C  N N 264 
LYS CE     C  N N 265 
LYS NZ     N  N N 266 
LYS OXT    O  N N 267 
LYS H      H  N N 268 
LYS H2     H  N N 269 
LYS HA     H  N N 270 
LYS HB2    H  N N 271 
LYS HB3    H  N N 272 
LYS HG2    H  N N 273 
LYS HG3    H  N N 274 
LYS HD2    H  N N 275 
LYS HD3    H  N N 276 
LYS HE2    H  N N 277 
LYS HE3    H  N N 278 
LYS HZ1    H  N N 279 
LYS HZ2    H  N N 280 
LYS HZ3    H  N N 281 
LYS HXT    H  N N 282 
MET N      N  N N 283 
MET CA     C  N S 284 
MET C      C  N N 285 
MET O      O  N N 286 
MET CB     C  N N 287 
MET CG     C  N N 288 
MET SD     S  N N 289 
MET CE     C  N N 290 
MET OXT    O  N N 291 
MET H      H  N N 292 
MET H2     H  N N 293 
MET HA     H  N N 294 
MET HB2    H  N N 295 
MET HB3    H  N N 296 
MET HG2    H  N N 297 
MET HG3    H  N N 298 
MET HE1    H  N N 299 
MET HE2    H  N N 300 
MET HE3    H  N N 301 
MET HXT    H  N N 302 
MG  MG     MG N N 303 
PEG C1     C  N N 304 
PEG O1     O  N N 305 
PEG C2     C  N N 306 
PEG O2     O  N N 307 
PEG C3     C  N N 308 
PEG C4     C  N N 309 
PEG O4     O  N N 310 
PEG H11    H  N N 311 
PEG H12    H  N N 312 
PEG HO1    H  N N 313 
PEG H21    H  N N 314 
PEG H22    H  N N 315 
PEG H31    H  N N 316 
PEG H32    H  N N 317 
PEG H41    H  N N 318 
PEG H42    H  N N 319 
PEG HO4    H  N N 320 
PHE N      N  N N 321 
PHE CA     C  N S 322 
PHE C      C  N N 323 
PHE O      O  N N 324 
PHE CB     C  N N 325 
PHE CG     C  Y N 326 
PHE CD1    C  Y N 327 
PHE CD2    C  Y N 328 
PHE CE1    C  Y N 329 
PHE CE2    C  Y N 330 
PHE CZ     C  Y N 331 
PHE OXT    O  N N 332 
PHE H      H  N N 333 
PHE H2     H  N N 334 
PHE HA     H  N N 335 
PHE HB2    H  N N 336 
PHE HB3    H  N N 337 
PHE HD1    H  N N 338 
PHE HD2    H  N N 339 
PHE HE1    H  N N 340 
PHE HE2    H  N N 341 
PHE HZ     H  N N 342 
PHE HXT    H  N N 343 
PRO N      N  N N 344 
PRO CA     C  N S 345 
PRO C      C  N N 346 
PRO O      O  N N 347 
PRO CB     C  N N 348 
PRO CG     C  N N 349 
PRO CD     C  N N 350 
PRO OXT    O  N N 351 
PRO H      H  N N 352 
PRO HA     H  N N 353 
PRO HB2    H  N N 354 
PRO HB3    H  N N 355 
PRO HG2    H  N N 356 
PRO HG3    H  N N 357 
PRO HD2    H  N N 358 
PRO HD3    H  N N 359 
PRO HXT    H  N N 360 
SER N      N  N N 361 
SER CA     C  N S 362 
SER C      C  N N 363 
SER O      O  N N 364 
SER CB     C  N N 365 
SER OG     O  N N 366 
SER OXT    O  N N 367 
SER H      H  N N 368 
SER H2     H  N N 369 
SER HA     H  N N 370 
SER HB2    H  N N 371 
SER HB3    H  N N 372 
SER HG     H  N N 373 
SER HXT    H  N N 374 
THR N      N  N N 375 
THR CA     C  N S 376 
THR C      C  N N 377 
THR O      O  N N 378 
THR CB     C  N R 379 
THR OG1    O  N N 380 
THR CG2    C  N N 381 
THR OXT    O  N N 382 
THR H      H  N N 383 
THR H2     H  N N 384 
THR HA     H  N N 385 
THR HB     H  N N 386 
THR HG1    H  N N 387 
THR HG21   H  N N 388 
THR HG22   H  N N 389 
THR HG23   H  N N 390 
THR HXT    H  N N 391 
TRP N      N  N N 392 
TRP CA     C  N S 393 
TRP C      C  N N 394 
TRP O      O  N N 395 
TRP CB     C  N N 396 
TRP CG     C  Y N 397 
TRP CD1    C  Y N 398 
TRP CD2    C  Y N 399 
TRP NE1    N  Y N 400 
TRP CE2    C  Y N 401 
TRP CE3    C  Y N 402 
TRP CZ2    C  Y N 403 
TRP CZ3    C  Y N 404 
TRP CH2    C  Y N 405 
TRP OXT    O  N N 406 
TRP H      H  N N 407 
TRP H2     H  N N 408 
TRP HA     H  N N 409 
TRP HB2    H  N N 410 
TRP HB3    H  N N 411 
TRP HD1    H  N N 412 
TRP HE1    H  N N 413 
TRP HE3    H  N N 414 
TRP HZ2    H  N N 415 
TRP HZ3    H  N N 416 
TRP HH2    H  N N 417 
TRP HXT    H  N N 418 
TYR N      N  N N 419 
TYR CA     C  N S 420 
TYR C      C  N N 421 
TYR O      O  N N 422 
TYR CB     C  N N 423 
TYR CG     C  Y N 424 
TYR CD1    C  Y N 425 
TYR CD2    C  Y N 426 
TYR CE1    C  Y N 427 
TYR CE2    C  Y N 428 
TYR CZ     C  Y N 429 
TYR OH     O  N N 430 
TYR OXT    O  N N 431 
TYR H      H  N N 432 
TYR H2     H  N N 433 
TYR HA     H  N N 434 
TYR HB2    H  N N 435 
TYR HB3    H  N N 436 
TYR HD1    H  N N 437 
TYR HD2    H  N N 438 
TYR HE1    H  N N 439 
TYR HE2    H  N N 440 
TYR HH     H  N N 441 
TYR HXT    H  N N 442 
VAL N      N  N N 443 
VAL CA     C  N S 444 
VAL C      C  N N 445 
VAL O      O  N N 446 
VAL CB     C  N N 447 
VAL CG1    C  N N 448 
VAL CG2    C  N N 449 
VAL OXT    O  N N 450 
VAL H      H  N N 451 
VAL H2     H  N N 452 
VAL HA     H  N N 453 
VAL HB     H  N N 454 
VAL HG11   H  N N 455 
VAL HG12   H  N N 456 
VAL HG13   H  N N 457 
VAL HG21   H  N N 458 
VAL HG22   H  N N 459 
VAL HG23   H  N N 460 
VAL HXT    H  N N 461 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A3P P1    O1P    doub N N 1   
A3P P1    O2P    sing N N 2   
A3P P1    O3P    sing N N 3   
A3P P1    "O3'"  sing N N 4   
A3P O2P   HOP2   sing N N 5   
A3P O3P   HOP3   sing N N 6   
A3P P2    O4P    doub N N 7   
A3P P2    O5P    sing N N 8   
A3P P2    O6P    sing N N 9   
A3P P2    "O5'"  sing N N 10  
A3P O5P   HOP5   sing N N 11  
A3P O6P   HOP6   sing N N 12  
A3P "O5'" "C5'"  sing N N 13  
A3P "C5'" "C4'"  sing N N 14  
A3P "C5'" "H5'1" sing N N 15  
A3P "C5'" "H5'2" sing N N 16  
A3P "C4'" "O4'"  sing N N 17  
A3P "C4'" "C3'"  sing N N 18  
A3P "C4'" "H4'"  sing N N 19  
A3P "O4'" "C1'"  sing N N 20  
A3P "C3'" "O3'"  sing N N 21  
A3P "C3'" "C2'"  sing N N 22  
A3P "C3'" "H3'"  sing N N 23  
A3P "C2'" "O2'"  sing N N 24  
A3P "C2'" "C1'"  sing N N 25  
A3P "C2'" "H2'"  sing N N 26  
A3P "O2'" "HO2'" sing N N 27  
A3P "C1'" N9     sing N N 28  
A3P "C1'" "H1'"  sing N N 29  
A3P N9    C8     sing Y N 30  
A3P N9    C4     sing Y N 31  
A3P C8    N7     doub Y N 32  
A3P C8    H8     sing N N 33  
A3P N7    C5     sing Y N 34  
A3P C5    C6     sing Y N 35  
A3P C5    C4     doub Y N 36  
A3P C6    N6     sing N N 37  
A3P C6    N1     doub Y N 38  
A3P N6    HN61   sing N N 39  
A3P N6    HN62   sing N N 40  
A3P N1    C2     sing Y N 41  
A3P C2    N3     doub Y N 42  
A3P C2    H2     sing N N 43  
A3P N3    C4     sing Y N 44  
ALA N     CA     sing N N 45  
ALA N     H      sing N N 46  
ALA N     H2     sing N N 47  
ALA CA    C      sing N N 48  
ALA CA    CB     sing N N 49  
ALA CA    HA     sing N N 50  
ALA C     O      doub N N 51  
ALA C     OXT    sing N N 52  
ALA CB    HB1    sing N N 53  
ALA CB    HB2    sing N N 54  
ALA CB    HB3    sing N N 55  
ALA OXT   HXT    sing N N 56  
ARG N     CA     sing N N 57  
ARG N     H      sing N N 58  
ARG N     H2     sing N N 59  
ARG CA    C      sing N N 60  
ARG CA    CB     sing N N 61  
ARG CA    HA     sing N N 62  
ARG C     O      doub N N 63  
ARG C     OXT    sing N N 64  
ARG CB    CG     sing N N 65  
ARG CB    HB2    sing N N 66  
ARG CB    HB3    sing N N 67  
ARG CG    CD     sing N N 68  
ARG CG    HG2    sing N N 69  
ARG CG    HG3    sing N N 70  
ARG CD    NE     sing N N 71  
ARG CD    HD2    sing N N 72  
ARG CD    HD3    sing N N 73  
ARG NE    CZ     sing N N 74  
ARG NE    HE     sing N N 75  
ARG CZ    NH1    sing N N 76  
ARG CZ    NH2    doub N N 77  
ARG NH1   HH11   sing N N 78  
ARG NH1   HH12   sing N N 79  
ARG NH2   HH21   sing N N 80  
ARG NH2   HH22   sing N N 81  
ARG OXT   HXT    sing N N 82  
ASN N     CA     sing N N 83  
ASN N     H      sing N N 84  
ASN N     H2     sing N N 85  
ASN CA    C      sing N N 86  
ASN CA    CB     sing N N 87  
ASN CA    HA     sing N N 88  
ASN C     O      doub N N 89  
ASN C     OXT    sing N N 90  
ASN CB    CG     sing N N 91  
ASN CB    HB2    sing N N 92  
ASN CB    HB3    sing N N 93  
ASN CG    OD1    doub N N 94  
ASN CG    ND2    sing N N 95  
ASN ND2   HD21   sing N N 96  
ASN ND2   HD22   sing N N 97  
ASN OXT   HXT    sing N N 98  
ASP N     CA     sing N N 99  
ASP N     H      sing N N 100 
ASP N     H2     sing N N 101 
ASP CA    C      sing N N 102 
ASP CA    CB     sing N N 103 
ASP CA    HA     sing N N 104 
ASP C     O      doub N N 105 
ASP C     OXT    sing N N 106 
ASP CB    CG     sing N N 107 
ASP CB    HB2    sing N N 108 
ASP CB    HB3    sing N N 109 
ASP CG    OD1    doub N N 110 
ASP CG    OD2    sing N N 111 
ASP OD2   HD2    sing N N 112 
ASP OXT   HXT    sing N N 113 
CYS N     CA     sing N N 114 
CYS N     H      sing N N 115 
CYS N     H2     sing N N 116 
CYS CA    C      sing N N 117 
CYS CA    CB     sing N N 118 
CYS CA    HA     sing N N 119 
CYS C     O      doub N N 120 
CYS C     OXT    sing N N 121 
CYS CB    SG     sing N N 122 
CYS CB    HB2    sing N N 123 
CYS CB    HB3    sing N N 124 
CYS SG    HG     sing N N 125 
CYS OXT   HXT    sing N N 126 
EDO C1    O1     sing N N 127 
EDO C1    C2     sing N N 128 
EDO C1    H11    sing N N 129 
EDO C1    H12    sing N N 130 
EDO O1    HO1    sing N N 131 
EDO C2    O2     sing N N 132 
EDO C2    H21    sing N N 133 
EDO C2    H22    sing N N 134 
EDO O2    HO2    sing N N 135 
GLN N     CA     sing N N 136 
GLN N     H      sing N N 137 
GLN N     H2     sing N N 138 
GLN CA    C      sing N N 139 
GLN CA    CB     sing N N 140 
GLN CA    HA     sing N N 141 
GLN C     O      doub N N 142 
GLN C     OXT    sing N N 143 
GLN CB    CG     sing N N 144 
GLN CB    HB2    sing N N 145 
GLN CB    HB3    sing N N 146 
GLN CG    CD     sing N N 147 
GLN CG    HG2    sing N N 148 
GLN CG    HG3    sing N N 149 
GLN CD    OE1    doub N N 150 
GLN CD    NE2    sing N N 151 
GLN NE2   HE21   sing N N 152 
GLN NE2   HE22   sing N N 153 
GLN OXT   HXT    sing N N 154 
GLU N     CA     sing N N 155 
GLU N     H      sing N N 156 
GLU N     H2     sing N N 157 
GLU CA    C      sing N N 158 
GLU CA    CB     sing N N 159 
GLU CA    HA     sing N N 160 
GLU C     O      doub N N 161 
GLU C     OXT    sing N N 162 
GLU CB    CG     sing N N 163 
GLU CB    HB2    sing N N 164 
GLU CB    HB3    sing N N 165 
GLU CG    CD     sing N N 166 
GLU CG    HG2    sing N N 167 
GLU CG    HG3    sing N N 168 
GLU CD    OE1    doub N N 169 
GLU CD    OE2    sing N N 170 
GLU OE2   HE2    sing N N 171 
GLU OXT   HXT    sing N N 172 
GLY N     CA     sing N N 173 
GLY N     H      sing N N 174 
GLY N     H2     sing N N 175 
GLY CA    C      sing N N 176 
GLY CA    HA2    sing N N 177 
GLY CA    HA3    sing N N 178 
GLY C     O      doub N N 179 
GLY C     OXT    sing N N 180 
GLY OXT   HXT    sing N N 181 
HIS N     CA     sing N N 182 
HIS N     H      sing N N 183 
HIS N     H2     sing N N 184 
HIS CA    C      sing N N 185 
HIS CA    CB     sing N N 186 
HIS CA    HA     sing N N 187 
HIS C     O      doub N N 188 
HIS C     OXT    sing N N 189 
HIS CB    CG     sing N N 190 
HIS CB    HB2    sing N N 191 
HIS CB    HB3    sing N N 192 
HIS CG    ND1    sing Y N 193 
HIS CG    CD2    doub Y N 194 
HIS ND1   CE1    doub Y N 195 
HIS ND1   HD1    sing N N 196 
HIS CD2   NE2    sing Y N 197 
HIS CD2   HD2    sing N N 198 
HIS CE1   NE2    sing Y N 199 
HIS CE1   HE1    sing N N 200 
HIS NE2   HE2    sing N N 201 
HIS OXT   HXT    sing N N 202 
HOH O     H1     sing N N 203 
HOH O     H2     sing N N 204 
ILE N     CA     sing N N 205 
ILE N     H      sing N N 206 
ILE N     H2     sing N N 207 
ILE CA    C      sing N N 208 
ILE CA    CB     sing N N 209 
ILE CA    HA     sing N N 210 
ILE C     O      doub N N 211 
ILE C     OXT    sing N N 212 
ILE CB    CG1    sing N N 213 
ILE CB    CG2    sing N N 214 
ILE CB    HB     sing N N 215 
ILE CG1   CD1    sing N N 216 
ILE CG1   HG12   sing N N 217 
ILE CG1   HG13   sing N N 218 
ILE CG2   HG21   sing N N 219 
ILE CG2   HG22   sing N N 220 
ILE CG2   HG23   sing N N 221 
ILE CD1   HD11   sing N N 222 
ILE CD1   HD12   sing N N 223 
ILE CD1   HD13   sing N N 224 
ILE OXT   HXT    sing N N 225 
LEU N     CA     sing N N 226 
LEU N     H      sing N N 227 
LEU N     H2     sing N N 228 
LEU CA    C      sing N N 229 
LEU CA    CB     sing N N 230 
LEU CA    HA     sing N N 231 
LEU C     O      doub N N 232 
LEU C     OXT    sing N N 233 
LEU CB    CG     sing N N 234 
LEU CB    HB2    sing N N 235 
LEU CB    HB3    sing N N 236 
LEU CG    CD1    sing N N 237 
LEU CG    CD2    sing N N 238 
LEU CG    HG     sing N N 239 
LEU CD1   HD11   sing N N 240 
LEU CD1   HD12   sing N N 241 
LEU CD1   HD13   sing N N 242 
LEU CD2   HD21   sing N N 243 
LEU CD2   HD22   sing N N 244 
LEU CD2   HD23   sing N N 245 
LEU OXT   HXT    sing N N 246 
LYS N     CA     sing N N 247 
LYS N     H      sing N N 248 
LYS N     H2     sing N N 249 
LYS CA    C      sing N N 250 
LYS CA    CB     sing N N 251 
LYS CA    HA     sing N N 252 
LYS C     O      doub N N 253 
LYS C     OXT    sing N N 254 
LYS CB    CG     sing N N 255 
LYS CB    HB2    sing N N 256 
LYS CB    HB3    sing N N 257 
LYS CG    CD     sing N N 258 
LYS CG    HG2    sing N N 259 
LYS CG    HG3    sing N N 260 
LYS CD    CE     sing N N 261 
LYS CD    HD2    sing N N 262 
LYS CD    HD3    sing N N 263 
LYS CE    NZ     sing N N 264 
LYS CE    HE2    sing N N 265 
LYS CE    HE3    sing N N 266 
LYS NZ    HZ1    sing N N 267 
LYS NZ    HZ2    sing N N 268 
LYS NZ    HZ3    sing N N 269 
LYS OXT   HXT    sing N N 270 
MET N     CA     sing N N 271 
MET N     H      sing N N 272 
MET N     H2     sing N N 273 
MET CA    C      sing N N 274 
MET CA    CB     sing N N 275 
MET CA    HA     sing N N 276 
MET C     O      doub N N 277 
MET C     OXT    sing N N 278 
MET CB    CG     sing N N 279 
MET CB    HB2    sing N N 280 
MET CB    HB3    sing N N 281 
MET CG    SD     sing N N 282 
MET CG    HG2    sing N N 283 
MET CG    HG3    sing N N 284 
MET SD    CE     sing N N 285 
MET CE    HE1    sing N N 286 
MET CE    HE2    sing N N 287 
MET CE    HE3    sing N N 288 
MET OXT   HXT    sing N N 289 
PEG C1    O1     sing N N 290 
PEG C1    C2     sing N N 291 
PEG C1    H11    sing N N 292 
PEG C1    H12    sing N N 293 
PEG O1    HO1    sing N N 294 
PEG C2    O2     sing N N 295 
PEG C2    H21    sing N N 296 
PEG C2    H22    sing N N 297 
PEG O2    C3     sing N N 298 
PEG C3    C4     sing N N 299 
PEG C3    H31    sing N N 300 
PEG C3    H32    sing N N 301 
PEG C4    O4     sing N N 302 
PEG C4    H41    sing N N 303 
PEG C4    H42    sing N N 304 
PEG O4    HO4    sing N N 305 
PHE N     CA     sing N N 306 
PHE N     H      sing N N 307 
PHE N     H2     sing N N 308 
PHE CA    C      sing N N 309 
PHE CA    CB     sing N N 310 
PHE CA    HA     sing N N 311 
PHE C     O      doub N N 312 
PHE C     OXT    sing N N 313 
PHE CB    CG     sing N N 314 
PHE CB    HB2    sing N N 315 
PHE CB    HB3    sing N N 316 
PHE CG    CD1    doub Y N 317 
PHE CG    CD2    sing Y N 318 
PHE CD1   CE1    sing Y N 319 
PHE CD1   HD1    sing N N 320 
PHE CD2   CE2    doub Y N 321 
PHE CD2   HD2    sing N N 322 
PHE CE1   CZ     doub Y N 323 
PHE CE1   HE1    sing N N 324 
PHE CE2   CZ     sing Y N 325 
PHE CE2   HE2    sing N N 326 
PHE CZ    HZ     sing N N 327 
PHE OXT   HXT    sing N N 328 
PRO N     CA     sing N N 329 
PRO N     CD     sing N N 330 
PRO N     H      sing N N 331 
PRO CA    C      sing N N 332 
PRO CA    CB     sing N N 333 
PRO CA    HA     sing N N 334 
PRO C     O      doub N N 335 
PRO C     OXT    sing N N 336 
PRO CB    CG     sing N N 337 
PRO CB    HB2    sing N N 338 
PRO CB    HB3    sing N N 339 
PRO CG    CD     sing N N 340 
PRO CG    HG2    sing N N 341 
PRO CG    HG3    sing N N 342 
PRO CD    HD2    sing N N 343 
PRO CD    HD3    sing N N 344 
PRO OXT   HXT    sing N N 345 
SER N     CA     sing N N 346 
SER N     H      sing N N 347 
SER N     H2     sing N N 348 
SER CA    C      sing N N 349 
SER CA    CB     sing N N 350 
SER CA    HA     sing N N 351 
SER C     O      doub N N 352 
SER C     OXT    sing N N 353 
SER CB    OG     sing N N 354 
SER CB    HB2    sing N N 355 
SER CB    HB3    sing N N 356 
SER OG    HG     sing N N 357 
SER OXT   HXT    sing N N 358 
THR N     CA     sing N N 359 
THR N     H      sing N N 360 
THR N     H2     sing N N 361 
THR CA    C      sing N N 362 
THR CA    CB     sing N N 363 
THR CA    HA     sing N N 364 
THR C     O      doub N N 365 
THR C     OXT    sing N N 366 
THR CB    OG1    sing N N 367 
THR CB    CG2    sing N N 368 
THR CB    HB     sing N N 369 
THR OG1   HG1    sing N N 370 
THR CG2   HG21   sing N N 371 
THR CG2   HG22   sing N N 372 
THR CG2   HG23   sing N N 373 
THR OXT   HXT    sing N N 374 
TRP N     CA     sing N N 375 
TRP N     H      sing N N 376 
TRP N     H2     sing N N 377 
TRP CA    C      sing N N 378 
TRP CA    CB     sing N N 379 
TRP CA    HA     sing N N 380 
TRP C     O      doub N N 381 
TRP C     OXT    sing N N 382 
TRP CB    CG     sing N N 383 
TRP CB    HB2    sing N N 384 
TRP CB    HB3    sing N N 385 
TRP CG    CD1    doub Y N 386 
TRP CG    CD2    sing Y N 387 
TRP CD1   NE1    sing Y N 388 
TRP CD1   HD1    sing N N 389 
TRP CD2   CE2    doub Y N 390 
TRP CD2   CE3    sing Y N 391 
TRP NE1   CE2    sing Y N 392 
TRP NE1   HE1    sing N N 393 
TRP CE2   CZ2    sing Y N 394 
TRP CE3   CZ3    doub Y N 395 
TRP CE3   HE3    sing N N 396 
TRP CZ2   CH2    doub Y N 397 
TRP CZ2   HZ2    sing N N 398 
TRP CZ3   CH2    sing Y N 399 
TRP CZ3   HZ3    sing N N 400 
TRP CH2   HH2    sing N N 401 
TRP OXT   HXT    sing N N 402 
TYR N     CA     sing N N 403 
TYR N     H      sing N N 404 
TYR N     H2     sing N N 405 
TYR CA    C      sing N N 406 
TYR CA    CB     sing N N 407 
TYR CA    HA     sing N N 408 
TYR C     O      doub N N 409 
TYR C     OXT    sing N N 410 
TYR CB    CG     sing N N 411 
TYR CB    HB2    sing N N 412 
TYR CB    HB3    sing N N 413 
TYR CG    CD1    doub Y N 414 
TYR CG    CD2    sing Y N 415 
TYR CD1   CE1    sing Y N 416 
TYR CD1   HD1    sing N N 417 
TYR CD2   CE2    doub Y N 418 
TYR CD2   HD2    sing N N 419 
TYR CE1   CZ     doub Y N 420 
TYR CE1   HE1    sing N N 421 
TYR CE2   CZ     sing Y N 422 
TYR CE2   HE2    sing N N 423 
TYR CZ    OH     sing N N 424 
TYR OH    HH     sing N N 425 
TYR OXT   HXT    sing N N 426 
VAL N     CA     sing N N 427 
VAL N     H      sing N N 428 
VAL N     H2     sing N N 429 
VAL CA    C      sing N N 430 
VAL CA    CB     sing N N 431 
VAL CA    HA     sing N N 432 
VAL C     O      doub N N 433 
VAL C     OXT    sing N N 434 
VAL CB    CG1    sing N N 435 
VAL CB    CG2    sing N N 436 
VAL CB    HB     sing N N 437 
VAL CG1   HG11   sing N N 438 
VAL CG1   HG12   sing N N 439 
VAL CG1   HG13   sing N N 440 
VAL CG2   HG21   sing N N 441 
VAL CG2   HG22   sing N N 442 
VAL CG2   HG23   sing N N 443 
VAL OXT   HXT    sing N N 444 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2Y35 
_pdbx_initial_refinement_model.details          'Residues 1-650' 
# 
_atom_sites.entry_id                    9E70 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016418 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015632 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.002754 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
CL 17 17 11.4601 0.0104  7.1962 1.1662  6.2554 18.5194 1.6455 47.7784 -9.5571  
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
MG 12 12 5.4265  2.8275  2.1759 79.2611 1.2283 0.3808  2.3099 7.1937  0.8594   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.1150   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 0.8669   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1     N  N     . GLY A 1 2   ? -23.106 -9.784  -26.825  1    52.504  ? 2    GLY A N     1 ? 
ATOM   2     C  CA    . GLY A 1 2   ? -22.745 -8.937  -27.979  1    50.976  ? 2    GLY A CA    1 ? 
ATOM   3     C  C     . GLY A 1 2   ? -21.382 -8.266  -27.794  1    51.42   ? 2    GLY A C     1 ? 
ATOM   4     O  O     . GLY A 1 2   ? -20.707 -8.462  -26.777  1    45.757  ? 2    GLY A O     1 ? 
ATOM   5     N  N     . VAL A 1 3   ? -21.006 -7.458  -28.798  1    46.031  ? 3    VAL A N     1 ? 
ATOM   6     C  CA    . VAL A 1 3   ? -19.746 -6.732  -28.819  1    42.521  ? 3    VAL A CA    1 ? 
ATOM   7     C  C     . VAL A 1 3   ? -20.048 -5.254  -29.051  1    44.034  ? 3    VAL A C     1 ? 
ATOM   8     O  O     . VAL A 1 3   ? -21.157 -4.907  -29.433  1    39.031  ? 3    VAL A O     1 ? 
ATOM   9     C  CB    . VAL A 1 3   ? -18.805 -7.325  -29.884  1    46.102  ? 3    VAL A CB    1 ? 
ATOM   10    C  CG1   . VAL A 1 3   ? -18.453 -8.772  -29.531  1    37.306  ? 3    VAL A CG1   1 ? 
ATOM   11    C  CG2   . VAL A 1 3   ? -19.386 -7.236  -31.301  1    38.079  ? 3    VAL A CG2   1 ? 
ATOM   12    N  N     . PRO A 1 4   ? -19.109 -4.328  -28.76   1    41.97   ? 4    PRO A N     1 ? 
ATOM   13    C  CA    . PRO A 1 4   ? -19.312 -2.919  -29.088  1    39.482  ? 4    PRO A CA    1 ? 
ATOM   14    C  C     . PRO A 1 4   ? -19.272 -2.681  -30.593  1    40.148  ? 4    PRO A C     1 ? 
ATOM   15    O  O     . PRO A 1 4   ? -18.58  -3.396  -31.313  1    45.688  ? 4    PRO A O     1 ? 
ATOM   16    C  CB    . PRO A 1 4   ? -18.199 -2.156  -28.373  1    37.389  ? 4    PRO A CB    1 ? 
ATOM   17    C  CG    . PRO A 1 4   ? -17.363 -3.207  -27.701  1    40.136  ? 4    PRO A CG    1 ? 
ATOM   18    C  CD    . PRO A 1 4   ? -17.833 -4.593  -28.081  1    38.234  ? 4    PRO A CD    1 ? 
ATOM   19    N  N     . LYS A 1 5   ? -19.944 -1.603  -31.017  1    42.259  ? 5    LYS A N     1 ? 
ATOM   20    C  CA    . LYS A 1 5   ? -20.166 -1.235  -32.406  1    44.236  ? 5    LYS A CA    1 ? 
ATOM   21    C  C     . LYS A 1 5   ? -18.849 -1.133  -33.166  1    40.035  ? 5    LYS A C     1 ? 
ATOM   22    O  O     . LYS A 1 5   ? -18.718 -1.694  -34.245  1    44.149  ? 5    LYS A O     1 ? 
ATOM   23    C  CB    . LYS A 1 5   ? -20.885 0.116   -32.551  1    52.085  ? 5    LYS A CB    1 ? 
ATOM   24    C  CG    . LYS A 1 5   ? -22.407 0.14    -32.535  1    70.396  ? 5    LYS A CG    1 ? 
ATOM   25    C  CD    . LYS A 1 5   ? -23.011 -0.58   -33.737  1    92.32   ? 5    LYS A CD    1 ? 
ATOM   26    C  CE    . LYS A 1 5   ? -24.072 0.191   -34.476  1    101.497 ? 5    LYS A CE    1 ? 
ATOM   27    N  NZ    . LYS A 1 5   ? -25.16  0.681   -33.626  1    116.406 ? 5    LYS A NZ    1 ? 
ATOM   28    N  N     . PHE A 1 6   ? -17.882 -0.389  -32.635  1    33.929  ? 6    PHE A N     1 ? 
ATOM   29    C  CA    . PHE A 1 6   ? -16.664 -0.22   -33.399  1    34.334  ? 6    PHE A CA    1 ? 
ATOM   30    C  C     . PHE A 1 6   ? -15.921 -1.553  -33.58   1    41.8    ? 6    PHE A C     1 ? 
ATOM   31    O  O     . PHE A 1 6   ? -15.373 -1.825  -34.655  1    42.209  ? 6    PHE A O     1 ? 
ATOM   32    C  CB    . PHE A 1 6   ? -15.799 0.844   -32.751  1    32.899  ? 6    PHE A CB    1 ? 
ATOM   33    C  CG    . PHE A 1 6   ? -14.585 1.154   -33.604  1    36.559  ? 6    PHE A CG    1 ? 
ATOM   34    C  CD1   . PHE A 1 6   ? -14.737 1.774   -34.84   1    41.83   ? 6    PHE A CD1   1 ? 
ATOM   35    C  CD2   . PHE A 1 6   ? -13.305 0.854   -33.157  1    35.098  ? 6    PHE A CD2   1 ? 
ATOM   36    C  CE1   . PHE A 1 6   ? -13.628 2.054   -35.62   1    41.668  ? 6    PHE A CE1   1 ? 
ATOM   37    C  CE2   . PHE A 1 6   ? -12.201 1.157   -33.926  1    41.731  ? 6    PHE A CE2   1 ? 
ATOM   38    C  CZ    . PHE A 1 6   ? -12.363 1.748   -35.165  1    44.472  ? 6    PHE A CZ    1 ? 
ATOM   39    N  N     . TYR A 1 7   ? -15.887 -2.393  -32.535  1    38.246  ? 7    TYR A N     1 ? 
ATOM   40    C  CA    . TYR A 1 7   ? -15.31  -3.727  -32.682  1    36.282  ? 7    TYR A CA    1 ? 
ATOM   41    C  C     . TYR A 1 7   ? -15.998 -4.513  -33.814  1    38.684  ? 7    TYR A C     1 ? 
ATOM   42    O  O     . TYR A 1 7   ? -15.324 -5.171  -34.622  1    33.69   ? 7    TYR A O     1 ? 
ATOM   43    C  CB    . TYR A 1 7   ? -15.479 -4.543  -31.404  1    34.721  ? 7    TYR A CB    1 ? 
ATOM   44    C  CG    . TYR A 1 7   ? -14.82  -5.914  -31.458  1    40.273  ? 7    TYR A CG    1 ? 
ATOM   45    C  CD1   . TYR A 1 7   ? -13.465 -6.076  -31.182  1    44.646  ? 7    TYR A CD1   1 ? 
ATOM   46    C  CD2   . TYR A 1 7   ? -15.566 -7.051  -31.735  1    39.211  ? 7    TYR A CD2   1 ? 
ATOM   47    C  CE1   . TYR A 1 7   ? -12.866 -7.327  -31.217  1    48.459  ? 7    TYR A CE1   1 ? 
ATOM   48    C  CE2   . TYR A 1 7   ? -14.984 -8.307  -31.754  1    44.022  ? 7    TYR A CE2   1 ? 
ATOM   49    C  CZ    . TYR A 1 7   ? -13.633 -8.445  -31.501  1    53.676  ? 7    TYR A CZ    1 ? 
ATOM   50    O  OH    . TYR A 1 7   ? -13.097 -9.698  -31.559  1    65.301  ? 7    TYR A OH    1 ? 
ATOM   51    N  N     . ARG A 1 8   ? -17.341 -4.539  -33.769  1    36.795  ? 8    ARG A N     1 ? 
ATOM   52    C  CA    . ARG A 1 8   ? -18.183 -5.246  -34.722  1    42.454  ? 8    ARG A CA    1 ? 
ATOM   53    C  C     . ARG A 1 8   ? -17.831 -4.746  -36.116  1    43.553  ? 8    ARG A C     1 ? 
ATOM   54    O  O     . ARG A 1 8   ? -17.63  -5.541  -37.035  1    42.47   ? 8    ARG A O     1 ? 
ATOM   55    C  CB    . ARG A 1 8   ? -19.667 -4.927  -34.497  1    44.66   ? 8    ARG A CB    1 ? 
ATOM   56    C  CG    . ARG A 1 8   ? -20.613 -5.981  -35.071  1    58.963  ? 8    ARG A CG    1 ? 
ATOM   57    C  CD    . ARG A 1 8   ? -22.109 -5.656  -34.983  1    58.168  ? 8    ARG A CD    1 ? 
ATOM   58    N  NE    . ARG A 1 8   ? -22.369 -4.751  -33.856  1    71.273  ? 8    ARG A NE    1 ? 
ATOM   59    C  CZ    . ARG A 1 8   ? -22.76  -5.07   -32.615  1    73.852  ? 8    ARG A CZ    1 ? 
ATOM   60    N  NH1   . ARG A 1 8   ? -23.015 -6.329  -32.279  1    69.368  ? 8    ARG A NH1   1 ? 
ATOM   61    N  NH2   . ARG A 1 8   ? -22.882 -4.11   -31.71   1    66.229  ? 8    ARG A NH2   1 ? 
ATOM   62    N  N     . TRP A 1 9   ? -17.689 -3.42   -36.221  1    38.657  ? 9    TRP A N     1 ? 
ATOM   63    C  CA    . TRP A 1 9   ? -17.432 -2.794  -37.496  1    40.859  ? 9    TRP A CA    1 ? 
ATOM   64    C  C     . TRP A 1 9   ? -16.115 -3.293  -38.09   1    44.209  ? 9    TRP A C     1 ? 
ATOM   65    O  O     . TRP A 1 9   ? -16.081 -3.705  -39.255  1    39.168  ? 9    TRP A O     1 ? 
ATOM   66    C  CB    . TRP A 1 9   ? -17.504 -1.262  -37.401  1    40.678  ? 9    TRP A CB    1 ? 
ATOM   67    C  CG    . TRP A 1 9   ? -17.301 -0.664  -38.766  1    46.725  ? 9    TRP A CG    1 ? 
ATOM   68    C  CD1   . TRP A 1 9   ? -18.235 -0.573  -39.764  1    49.906  ? 9    TRP A CD1   1 ? 
ATOM   69    C  CD2   . TRP A 1 9   ? -16.058 -0.192  -39.329  1    48.103  ? 9    TRP A CD2   1 ? 
ATOM   70    N  NE1   . TRP A 1 9   ? -17.669 -0.053  -40.9    1    48.832  ? 9    TRP A NE1   1 ? 
ATOM   71    C  CE2   . TRP A 1 9   ? -16.337 0.189   -40.664  1    53.149  ? 9    TRP A CE2   1 ? 
ATOM   72    C  CE3   . TRP A 1 9   ? -14.758 -0.033  -38.832  1    51.689  ? 9    TRP A CE3   1 ? 
ATOM   73    C  CZ2   . TRP A 1 9   ? -15.352 0.707   -41.503  1    52.674  ? 9    TRP A CZ2   1 ? 
ATOM   74    C  CZ3   . TRP A 1 9   ? -13.792 0.5     -39.656  1    56.734  ? 9    TRP A CZ3   1 ? 
ATOM   75    C  CH2   . TRP A 1 9   ? -14.085 0.842   -40.978  1    59.616  ? 9    TRP A CH2   1 ? 
ATOM   76    N  N     . ILE A 1 10  ? -15.028 -3.268  -37.301  1    37.975  ? 10   ILE A N     1 ? 
ATOM   77    C  CA    . ILE A 1 10  ? -13.746 -3.683  -37.849  1    42.88   ? 10   ILE A CA    1 ? 
ATOM   78    C  C     . ILE A 1 10  ? -13.731 -5.18   -38.125  1    40.588  ? 10   ILE A C     1 ? 
ATOM   79    O  O     . ILE A 1 10  ? -12.995 -5.607  -39.004  1    43.787  ? 10   ILE A O     1 ? 
ATOM   80    C  CB    . ILE A 1 10  ? -12.521 -3.24   -37.03   1    48.416  ? 10   ILE A CB    1 ? 
ATOM   81    C  CG1   . ILE A 1 10  ? -12.53  -3.826  -35.639  1    55.212  ? 10   ILE A CG1   1 ? 
ATOM   82    C  CG2   . ILE A 1 10  ? -12.397 -1.714  -37.005  1    46.06   ? 10   ILE A CG2   1 ? 
ATOM   83    C  CD1   . ILE A 1 10  ? -11.798 -2.964  -34.627  1    69.5    ? 10   ILE A CD1   1 ? 
ATOM   84    N  N     . SER A 1 11  ? -14.534 -5.945  -37.379  1    40.798  ? 11   SER A N     1 ? 
ATOM   85    C  CA    . SER A 1 11  ? -14.727 -7.377  -37.58   1    47.398  ? 11   SER A CA    1 ? 
ATOM   86    C  C     . SER A 1 11  ? -15.355 -7.663  -38.948  1    46.799  ? 11   SER A C     1 ? 
ATOM   87    O  O     . SER A 1 11  ? -15.035 -8.666  -39.588  1    49.089  ? 11   SER A O     1 ? 
ATOM   88    C  CB    . SER A 1 11  ? -15.599 -7.961  -36.486  1    46.905  ? 11   SER A CB    1 ? 
ATOM   89    O  OG    . SER A 1 11  ? -14.863 -8.042  -35.273  1    58.204  ? 11   SER A OG    1 ? 
ATOM   90    N  N     . GLU A 1 12  ? -16.265 -6.778  -39.375  1    43.299  ? 12   GLU A N     1 ? 
ATOM   91    C  CA    . GLU A 1 12  ? -16.931 -6.897  -40.662  1    43.711  ? 12   GLU A CA    1 ? 
ATOM   92    C  C     . GLU A 1 12  ? -16.032 -6.364  -41.779  1    47.504  ? 12   GLU A C     1 ? 
ATOM   93    O  O     . GLU A 1 12  ? -15.983 -6.937  -42.866  1    51.893  ? 12   GLU A O     1 ? 
ATOM   94    C  CB    . GLU A 1 12  ? -18.321 -6.283  -40.541  1    38.875  ? 12   GLU A CB    1 ? 
ATOM   95    C  CG    . GLU A 1 12  ? -19.22  -7.126  -39.643  1    43.318  ? 12   GLU A CG    1 ? 
ATOM   96    C  CD    . GLU A 1 12  ? -20.576 -6.543  -39.257  1    53.911  ? 12   GLU A CD    1 ? 
ATOM   97    O  OE1   . GLU A 1 12  ? -20.849 -5.32   -39.449  1    51.419  ? 12   GLU A OE1   1 ? 
ATOM   98    O  OE2   . GLU A 1 12  ? -21.385 -7.368  -38.759  1    66.027  ? 12   GLU A OE2   1 ? 
ATOM   99    N  N     . ARG A 1 13  ? -15.29  -5.288  -41.514  1    44.164  ? 13   ARG A N     1 ? 
ATOM   100   C  CA    . ARG A 1 13  ? -14.481 -4.706  -42.571  1    46.083  ? 13   ARG A CA    1 ? 
ATOM   101   C  C     . ARG A 1 13  ? -13.273 -5.6    -42.864  1    49.714  ? 13   ARG A C     1 ? 
ATOM   102   O  O     . ARG A 1 13  ? -12.851 -5.725  -44.012  1    50.389  ? 13   ARG A O     1 ? 
ATOM   103   C  CB    . ARG A 1 13  ? -14.099 -3.259  -42.24   1    49.61   ? 13   ARG A CB    1 ? 
ATOM   104   C  CG    . ARG A 1 13  ? -13.561 -2.607  -43.506  1    71.443  ? 13   ARG A CG    1 ? 
ATOM   105   C  CD    . ARG A 1 13  ? -13.535 -1.084  -43.564  1    90.018  ? 13   ARG A CD    1 ? 
ATOM   106   N  NE    . ARG A 1 13  ? -13.12  -0.639  -44.899  1    95.318  ? 13   ARG A NE    1 ? 
ATOM   107   C  CZ    . ARG A 1 13  ? -13.826 -0.814  -46.012  1    109.342 ? 13   ARG A CZ    1 ? 
ATOM   108   N  NH1   . ARG A 1 13  ? -15.091 -1.212  -45.96   1    115.19  ? 13   ARG A NH1   1 ? 
ATOM   109   N  NH2   . ARG A 1 13  ? -13.268 -0.555  -47.18   1    109.033 ? 13   ARG A NH2   1 ? 
ATOM   110   N  N     . TYR A 1 14  ? -12.693 -6.197  -41.815  1    43.165  ? 14   TYR A N     1 ? 
ATOM   111   C  CA    . TYR A 1 14  ? -11.533 -7.056  -41.975  1    51.176  ? 14   TYR A CA    1 ? 
ATOM   112   C  C     . TYR A 1 14  ? -11.9   -8.428  -41.414  1    64.616  ? 14   TYR A C     1 ? 
ATOM   113   O  O     . TYR A 1 14  ? -11.774 -8.658  -40.216  1    76.012  ? 14   TYR A O     1 ? 
ATOM   114   C  CB    . TYR A 1 14  ? -10.273 -6.444  -41.352  1    49.015  ? 14   TYR A CB    1 ? 
ATOM   115   C  CG    . TYR A 1 14  ? -10.04  -4.951  -41.571  1    57.809  ? 14   TYR A CG    1 ? 
ATOM   116   C  CD1   . TYR A 1 14  ? -9.417  -4.467  -42.724  1    59.299  ? 14   TYR A CD1   1 ? 
ATOM   117   C  CD2   . TYR A 1 14  ? -10.423 -4.02   -40.609  1    58.414  ? 14   TYR A CD2   1 ? 
ATOM   118   C  CE1   . TYR A 1 14  ? -9.187  -3.11   -42.908  1    56.922  ? 14   TYR A CE1   1 ? 
ATOM   119   C  CE2   . TYR A 1 14  ? -10.212 -2.661  -40.792  1    58.96   ? 14   TYR A CE2   1 ? 
ATOM   120   C  CZ    . TYR A 1 14  ? -9.588  -2.202  -41.941  1    54.683  ? 14   TYR A CZ    1 ? 
ATOM   121   O  OH    . TYR A 1 14  ? -9.395  -0.853  -42.113  1    57.657  ? 14   TYR A OH    1 ? 
ATOM   122   N  N     . PRO A 1 15  ? -12.351 -9.389  -42.253  1    72.246  ? 15   PRO A N     1 ? 
ATOM   123   C  CA    . PRO A 1 15  ? -13.097 -10.548 -41.752  1    74.057  ? 15   PRO A CA    1 ? 
ATOM   124   C  C     . PRO A 1 15  ? -12.242 -11.651 -41.13   1    70.916  ? 15   PRO A C     1 ? 
ATOM   125   O  O     . PRO A 1 15  ? -12.756 -12.457 -40.356  1    74.25   ? 15   PRO A O     1 ? 
ATOM   126   C  CB    . PRO A 1 15  ? -13.804 -11.008 -43.031  1    75.982  ? 15   PRO A CB    1 ? 
ATOM   127   C  CG    . PRO A 1 15  ? -12.767 -10.761 -44.109  1    75.478  ? 15   PRO A CG    1 ? 
ATOM   128   C  CD    . PRO A 1 15  ? -12.1   -9.45   -43.704  1    73.48   ? 15   PRO A CD    1 ? 
ATOM   129   N  N     . CYS A 1 16  ? -10.949 -11.669 -41.488  1    67.298  ? 16   CYS A N     1 ? 
ATOM   130   C  CA    . CYS A 1 16  ? -9.99   -12.639 -40.987  1    74.541  ? 16   CYS A CA    1 ? 
ATOM   131   C  C     . CYS A 1 16  ? -9.143  -11.983 -39.905  1    71.072  ? 16   CYS A C     1 ? 
ATOM   132   O  O     . CYS A 1 16  ? -7.944  -12.234 -39.814  1    73.923  ? 16   CYS A O     1 ? 
ATOM   133   C  CB    . CYS A 1 16  ? -9.04   -13.111 -42.085  1    91.854  ? 16   CYS A CB    1 ? 
ATOM   134   S  SG    . CYS A 1 16  ? -9.763  -14.262 -43.286  1    114.756 ? 16   CYS A SG    1 ? 
ATOM   135   N  N     . LEU A 1 17  ? -9.788  -11.14  -39.091  1    75.007  ? 17   LEU A N     1 ? 
ATOM   136   C  CA    . LEU A 1 17  ? -9.089  -10.313 -38.122  1    68.913  ? 17   LEU A CA    1 ? 
ATOM   137   C  C     . LEU A 1 17  ? -9.364  -10.821 -36.713  1    68.483  ? 17   LEU A C     1 ? 
ATOM   138   O  O     . LEU A 1 17  ? -8.454  -10.925 -35.891  1    76.998  ? 17   LEU A O     1 ? 
ATOM   139   C  CB    . LEU A 1 17  ? -9.513  -8.851  -38.256  1    63.615  ? 17   LEU A CB    1 ? 
ATOM   140   C  CG    . LEU A 1 17  ? -8.719  -7.855  -37.409  1    58.087  ? 17   LEU A CG    1 ? 
ATOM   141   C  CD1   . LEU A 1 17  ? -7.232  -8.16   -37.585  1    51.438  ? 17   LEU A CD1   1 ? 
ATOM   142   C  CD2   . LEU A 1 17  ? -9.036  -6.394  -37.736  1    57.376  ? 17   LEU A CD2   1 ? 
ATOM   143   N  N     . SER A 1 18  ? -10.634 -11.109 -36.443  1    59.955  ? 18   SER A N     1 ? 
ATOM   144   C  CA    . SER A 1 18  ? -11.039 -11.378 -35.082  1    58.328  ? 18   SER A CA    1 ? 
ATOM   145   C  C     . SER A 1 18  ? -11.691 -12.76  -34.977  1    61.475  ? 18   SER A C     1 ? 
ATOM   146   O  O     . SER A 1 18  ? -12.803 -12.984 -35.462  1    59.986  ? 18   SER A O     1 ? 
ATOM   147   C  CB    . SER A 1 18  ? -11.931 -10.276 -34.607  1    56.892  ? 18   SER A CB    1 ? 
ATOM   148   O  OG    . SER A 1 18  ? -13.097 -10.264 -35.413  1    59.173  ? 18   SER A OG    1 ? 
ATOM   149   N  N     . GLU A 1 19  ? -10.972 -13.675 -34.315  1    62.234  ? 19   GLU A N     1 ? 
ATOM   150   C  CA    . GLU A 1 19  ? -11.41  -15.032 -34.021  1    55.938  ? 19   GLU A CA    1 ? 
ATOM   151   C  C     . GLU A 1 19  ? -12.254 -15.037 -32.743  1    52.766  ? 19   GLU A C     1 ? 
ATOM   152   O  O     . GLU A 1 19  ? -12.223 -14.08  -31.964  1    47.145  ? 19   GLU A O     1 ? 
ATOM   153   C  CB    . GLU A 1 19  ? -10.161 -15.878 -33.765  1    60.611  ? 19   GLU A CB    1 ? 
ATOM   154   C  CG    . GLU A 1 19  ? -9.092  -15.766 -34.853  1    77.786  ? 19   GLU A CG    1 ? 
ATOM   155   C  CD    . GLU A 1 19  ? -7.649  -15.935 -34.38   1    94.2    ? 19   GLU A CD    1 ? 
ATOM   156   O  OE1   . GLU A 1 19  ? -6.838  -14.994 -34.571  1    97.204  ? 19   GLU A OE1   1 ? 
ATOM   157   O  OE2   . GLU A 1 19  ? -7.318  -17.003 -33.814  1    100.821 ? 19   GLU A OE2   1 ? 
ATOM   158   N  N     . VAL A 1 20  ? -13.029 -16.114 -32.555  1    45.44   ? 20   VAL A N     1 ? 
ATOM   159   C  CA    . VAL A 1 20  ? -13.555 -16.508 -31.262  1    41.986  ? 20   VAL A CA    1 ? 
ATOM   160   C  C     . VAL A 1 20  ? -12.862 -17.816 -30.903  1    50.418  ? 20   VAL A C     1 ? 
ATOM   161   O  O     . VAL A 1 20  ? -12.951 -18.777 -31.667  1    57.603  ? 20   VAL A O     1 ? 
ATOM   162   C  CB    . VAL A 1 20  ? -15.068 -16.727 -31.362  1    47.103  ? 20   VAL A CB    1 ? 
ATOM   163   C  CG1   . VAL A 1 20  ? -15.637 -17.25  -30.054  1    51.742  ? 20   VAL A CG1   1 ? 
ATOM   164   C  CG2   . VAL A 1 20  ? -15.787 -15.467 -31.833  1    45.427  ? 20   VAL A CG2   1 ? 
ATOM   165   N  N     . VAL A 1 21  ? -12.132 -17.836 -29.781  1    46.115  ? 21   VAL A N     1 ? 
ATOM   166   C  CA    . VAL A 1 21  ? -11.27  -18.972 -29.474  1    45.632  ? 21   VAL A CA    1 ? 
ATOM   167   C  C     . VAL A 1 21  ? -11.68  -19.572 -28.135  1    50.134  ? 21   VAL A C     1 ? 
ATOM   168   O  O     . VAL A 1 21  ? -12.298 -18.894 -27.312  1    51.831  ? 21   VAL A O     1 ? 
ATOM   169   C  CB    . VAL A 1 21  ? -9.767  -18.657 -29.516  1    39.559  ? 21   VAL A CB    1 ? 
ATOM   170   C  CG1   . VAL A 1 21  ? -9.33   -18.236 -30.911  1    43.828  ? 21   VAL A CG1   1 ? 
ATOM   171   C  CG2   . VAL A 1 21  ? -9.36   -17.608 -28.489  1    43.265  ? 21   VAL A CG2   1 ? 
ATOM   172   N  N     . LYS A 1 22  ? -11.363 -20.861 -27.945  1    49.786  ? 22   LYS A N     1 ? 
ATOM   173   C  CA    . LYS A 1 22  ? -11.599 -21.505 -26.658  1    54.706  ? 22   LYS A CA    1 ? 
ATOM   174   C  C     . LYS A 1 22  ? -10.412 -21.15  -25.766  1    40.995  ? 22   LYS A C     1 ? 
ATOM   175   O  O     . LYS A 1 22  ? -9.398  -20.686 -26.278  1    42.447  ? 22   LYS A O     1 ? 
ATOM   176   C  CB    . LYS A 1 22  ? -11.869 -23.019 -26.751  1    56.784  ? 22   LYS A CB    1 ? 
ATOM   177   C  CG    . LYS A 1 22  ? -12.632 -23.499 -27.986  1    58.561  ? 22   LYS A CG    1 ? 
ATOM   178   C  CD    . LYS A 1 22  ? -13.694 -24.583 -27.797  1    67.976  ? 22   LYS A CD    1 ? 
ATOM   179   C  CE    . LYS A 1 22  ? -14.388 -24.98  -29.077  1    59.714  ? 22   LYS A CE    1 ? 
ATOM   180   N  NZ    . LYS A 1 22  ? -13.546 -25.803 -29.959  1    61.671  ? 22   LYS A NZ    1 ? 
ATOM   181   N  N     . GLU A 1 23  ? -10.57  -21.317 -24.447  1    43.352  ? 23   GLU A N     1 ? 
ATOM   182   C  CA    . GLU A 1 23  ? -9.519  -21.035 -23.479  1    41.801  ? 23   GLU A CA    1 ? 
ATOM   183   C  C     . GLU A 1 23  ? -8.189  -21.631 -23.925  1    50.84   ? 23   GLU A C     1 ? 
ATOM   184   O  O     . GLU A 1 23  ? -7.163  -20.948 -23.921  1    48.317  ? 23   GLU A O     1 ? 
ATOM   185   C  CB    . GLU A 1 23  ? -9.791  -21.72  -22.146  1    48.805  ? 23   GLU A CB    1 ? 
ATOM   186   C  CG    . GLU A 1 23  ? -10.721 -20.903 -21.265  1    49.81   ? 23   GLU A CG    1 ? 
ATOM   187   C  CD    . GLU A 1 23  ? -10.901 -21.504 -19.894  1    51.764  ? 23   GLU A CD    1 ? 
ATOM   188   O  OE1   . GLU A 1 23  ? -9.901  -21.862 -19.204  1    51.855  ? 23   GLU A OE1   1 ? 
ATOM   189   O  OE2   . GLU A 1 23  ? -12.095 -21.586 -19.542  1    50.954  ? 23   GLU A OE2   1 ? 
ATOM   190   N  N     . HIS A 1 24  ? -8.222  -22.914 -24.307  1    48.434  ? 24   HIS A N     1 ? 
ATOM   191   C  CA    . HIS A 1 24  ? -7.004  -23.688 -24.473  1    48.61   ? 24   HIS A CA    1 ? 
ATOM   192   C  C     . HIS A 1 24  ? -6.226  -23.149 -25.67   1    49.252  ? 24   HIS A C     1 ? 
ATOM   193   O  O     . HIS A 1 24  ? -5.05   -23.468 -25.838  1    54.161  ? 24   HIS A O     1 ? 
ATOM   194   C  CB    . HIS A 1 24  ? -7.311  -25.19  -24.534  1    54.15   ? 24   HIS A CB    1 ? 
ATOM   195   C  CG    . HIS A 1 24  ? -7.971  -25.621 -25.807  1    55.773  ? 24   HIS A CG    1 ? 
ATOM   196   N  ND1   . HIS A 1 24  ? -9.337  -25.798 -25.914  1    61.991  ? 24   HIS A ND1   1 ? 
ATOM   197   C  CD2   . HIS A 1 24  ? -7.453  -25.886 -27.026  1    50.833  ? 24   HIS A CD2   1 ? 
ATOM   198   C  CE1   . HIS A 1 24  ? -9.627  -26.155 -27.16   1    59.791  ? 24   HIS A CE1   1 ? 
ATOM   199   N  NE2   . HIS A 1 24  ? -8.501  -26.21  -27.849  1    56.89   ? 24   HIS A NE2   1 ? 
ATOM   200   N  N     . GLN A 1 25  ? -6.883  -22.315 -26.488  1    44.754  ? 25   GLN A N     1 ? 
ATOM   201   C  CA    . GLN A 1 25  ? -6.224  -21.766 -27.665  1    44.906  ? 25   GLN A CA    1 ? 
ATOM   202   C  C     . GLN A 1 25  ? -5.774  -20.316 -27.458  1    43.37   ? 25   GLN A C     1 ? 
ATOM   203   O  O     . GLN A 1 25  ? -5.28   -19.707 -28.409  1    42.909  ? 25   GLN A O     1 ? 
ATOM   204   C  CB    . GLN A 1 25  ? -7.182  -21.714 -28.853  1    49.951  ? 25   GLN A CB    1 ? 
ATOM   205   C  CG    . GLN A 1 25  ? -7.88   -23.037 -29.141  1    58.254  ? 25   GLN A CG    1 ? 
ATOM   206   C  CD    . GLN A 1 25  ? -8.716  -22.964 -30.395  1    64.094  ? 25   GLN A CD    1 ? 
ATOM   207   O  OE1   . GLN A 1 25  ? -9.923  -22.701 -30.346  1    62.936  ? 25   GLN A OE1   1 ? 
ATOM   208   N  NE2   . GLN A 1 25  ? -8.052  -23.118 -31.532  1    61.583  ? 25   GLN A NE2   1 ? 
ATOM   209   N  N     . ILE A 1 26  ? -5.976  -19.74  -26.257  1    38.749  ? 26   ILE A N     1 ? 
ATOM   210   C  CA    . ILE A 1 26  ? -5.468  -18.398 -25.989  1    37.567  ? 26   ILE A CA    1 ? 
ATOM   211   C  C     . ILE A 1 26  ? -3.934  -18.43  -26.035  1    37.588  ? 26   ILE A C     1 ? 
ATOM   212   O  O     . ILE A 1 26  ? -3.311  -19.166 -25.282  1    40.917  ? 26   ILE A O     1 ? 
ATOM   213   C  CB    . ILE A 1 26  ? -6.011  -17.834 -24.656  1    36.771  ? 26   ILE A CB    1 ? 
ATOM   214   C  CG1   . ILE A 1 26  ? -7.521  -17.595 -24.753  1    33.908  ? 26   ILE A CG1   1 ? 
ATOM   215   C  CG2   . ILE A 1 26  ? -5.298  -16.525 -24.274  1    30.964  ? 26   ILE A CG2   1 ? 
ATOM   216   C  CD1   . ILE A 1 26  ? -8.207  -17.527 -23.403  1    37.613  ? 26   ILE A CD1   1 ? 
ATOM   217   N  N     . PRO A 1 27  ? -3.256  -17.619 -26.878  1    40.46   ? 27   PRO A N     1 ? 
ATOM   218   C  CA    . PRO A 1 27  ? -1.794  -17.613 -26.896  1    41.633  ? 27   PRO A CA    1 ? 
ATOM   219   C  C     . PRO A 1 27  ? -1.243  -17.104 -25.568  1    41.397  ? 27   PRO A C     1 ? 
ATOM   220   O  O     . PRO A 1 27  ? -1.987  -16.608 -24.719  1    38.95   ? 27   PRO A O     1 ? 
ATOM   221   C  CB    . PRO A 1 27  ? -1.461  -16.662 -28.054  1    41.924  ? 27   PRO A CB    1 ? 
ATOM   222   C  CG    . PRO A 1 27  ? -2.653  -15.75  -28.121  1    38.959  ? 27   PRO A CG    1 ? 
ATOM   223   C  CD    . PRO A 1 27  ? -3.831  -16.659 -27.833  1    38.738  ? 27   PRO A CD    1 ? 
ATOM   224   N  N     . GLU A 1 28  ? 0.071   -17.263 -25.424  1    36.978  ? 28   GLU A N     1 ? 
ATOM   225   C  CA    . GLU A 1 28  ? 0.849   -16.809 -24.288  1    37.526  ? 28   GLU A CA    1 ? 
ATOM   226   C  C     . GLU A 1 28  ? 0.96    -15.287 -24.322  1    31.27   ? 28   GLU A C     1 ? 
ATOM   227   O  O     . GLU A 1 28  ? 1.082   -14.708 -25.393  1    30.027  ? 28   GLU A O     1 ? 
ATOM   228   C  CB    . GLU A 1 28  ? 2.266   -17.348 -24.49   1    37.761  ? 28   GLU A CB    1 ? 
ATOM   229   C  CG    . GLU A 1 28  ? 2.487   -18.733 -23.888  1    48.707  ? 28   GLU A CG    1 ? 
ATOM   230   C  CD    . GLU A 1 28  ? 3.914   -19.246 -24.087  1    63.88   ? 28   GLU A CD    1 ? 
ATOM   231   O  OE1   . GLU A 1 28  ? 4.011   -20.398 -24.569  1    71.915  ? 28   GLU A OE1   1 ? 
ATOM   232   O  OE2   . GLU A 1 28  ? 4.92    -18.54  -23.792  1    57.334  ? 28   GLU A OE2   1 ? 
ATOM   233   N  N     . PHE A 1 29  ? 0.989   -14.651 -23.137  1    28.595  ? 29   PHE A N     1 ? 
ATOM   234   C  CA    . PHE A 1 29  ? 1.072   -13.196 -23.049  1    25.386  ? 29   PHE A CA    1 ? 
ATOM   235   C  C     . PHE A 1 29  ? 2.122   -12.868 -22.004  1    24.363  ? 29   PHE A C     1 ? 
ATOM   236   O  O     . PHE A 1 29  ? 2.201   -13.594 -21.024  1    26.281  ? 29   PHE A O     1 ? 
ATOM   237   C  CB    . PHE A 1 29  ? -0.33   -12.74  -22.616  1    25.446  ? 29   PHE A CB    1 ? 
ATOM   238   C  CG    . PHE A 1 29  ? -1.318  -12.641 -23.778  1    26.277  ? 29   PHE A CG    1 ? 
ATOM   239   C  CD1   . PHE A 1 29  ? -1.019  -11.881 -24.898  1    28.247  ? 29   PHE A CD1   1 ? 
ATOM   240   C  CD2   . PHE A 1 29  ? -2.539  -13.315 -23.738  1    29.725  ? 29   PHE A CD2   1 ? 
ATOM   241   C  CE1   . PHE A 1 29  ? -1.899  -11.824 -25.985  1    29.382  ? 29   PHE A CE1   1 ? 
ATOM   242   C  CE2   . PHE A 1 29  ? -3.425  -13.248 -24.802  1    30.986  ? 29   PHE A CE2   1 ? 
ATOM   243   C  CZ    . PHE A 1 29  ? -3.106  -12.502 -25.913  1    31.583  ? 29   PHE A CZ    1 ? 
ATOM   244   N  N     . ASP A 1 30  ? 2.896   -11.794 -22.203  1    24.679  ? 30   ASP A N     1 ? 
ATOM   245   C  CA    . ASP A 1 30  ? 3.796   -11.318 -21.148  1    26.696  ? 30   ASP A CA    1 ? 
ATOM   246   C  C     . ASP A 1 30  ? 3.111   -10.378 -20.143  1    28.251  ? 30   ASP A C     1 ? 
ATOM   247   O  O     . ASP A 1 30  ? 3.346   -10.485 -18.931  1    27.067  ? 30   ASP A O     1 ? 
ATOM   248   C  CB    . ASP A 1 30  ? 5.057   -10.719 -21.741  1    22.609  ? 30   ASP A CB    1 ? 
ATOM   249   C  CG    . ASP A 1 30  ? 5.7     -11.682 -22.718  1    30.296  ? 30   ASP A CG    1 ? 
ATOM   250   O  OD1   . ASP A 1 30  ? 5.943   -12.826 -22.274  1    29.22   ? 30   ASP A OD1   1 ? 
ATOM   251   O  OD2   . ASP A 1 30  ? 5.873   -11.3   -23.928  1    32.515  ? 30   ASP A OD2   1 ? 
ATOM   252   N  N     . ASN A 1 31  ? 2.335   -9.42   -20.675  1    23.519  ? 31   ASN A N     1 ? 
ATOM   253   C  CA    . ASN A 1 31  ? 1.761   -8.325  -19.907  1    25.659  ? 31   ASN A CA    1 ? 
ATOM   254   C  C     . ASN A 1 31  ? 0.232   -8.373  -20.064  1    27.235  ? 31   ASN A C     1 ? 
ATOM   255   O  O     . ASN A 1 31  ? -0.269  -8.513  -21.175  1    26.618  ? 31   ASN A O     1 ? 
ATOM   256   C  CB    . ASN A 1 31  ? 2.28    -6.986  -20.432  1    25.593  ? 31   ASN A CB    1 ? 
ATOM   257   C  CG    . ASN A 1 31  ? 3.755   -6.723  -20.202  1    28.242  ? 31   ASN A CG    1 ? 
ATOM   258   O  OD1   . ASN A 1 31  ? 4.548   -7.645  -19.937  1    25.579  ? 31   ASN A OD1   1 ? 
ATOM   259   N  ND2   . ASN A 1 31  ? 4.129   -5.451  -20.267  1    25.538  ? 31   ASN A ND2   1 ? 
ATOM   260   N  N     . LEU A 1 32  ? -0.514  -8.31   -18.958  1    26.539  ? 32   LEU A N     1 ? 
ATOM   261   C  CA    . LEU A 1 32  ? -1.977  -8.204  -18.997  1    22.844  ? 32   LEU A CA    1 ? 
ATOM   262   C  C     . LEU A 1 32  ? -2.354  -6.88   -18.333  1    23.528  ? 32   LEU A C     1 ? 
ATOM   263   O  O     . LEU A 1 32  ? -1.869  -6.562  -17.245  1    21.121  ? 32   LEU A O     1 ? 
ATOM   264   C  CB    . LEU A 1 32  ? -2.616  -9.404  -18.281  1    23.16   ? 32   LEU A CB    1 ? 
ATOM   265   C  CG    . LEU A 1 32  ? -4.124  -9.318  -17.992  1    22.143  ? 32   LEU A CG    1 ? 
ATOM   266   C  CD1   . LEU A 1 32  ? -4.92   -9.149  -19.308  1    20.334  ? 32   LEU A CD1   1 ? 
ATOM   267   C  CD2   . LEU A 1 32  ? -4.651  -10.506 -17.202  1    21.215  ? 32   LEU A CD2   1 ? 
ATOM   268   N  N     . TYR A 1 33  ? -3.185  -6.089  -19.015  1    23.438  ? 33   TYR A N     1 ? 
ATOM   269   C  CA    . TYR A 1 33  ? -3.674  -4.812  -18.516  1    23.142  ? 33   TYR A CA    1 ? 
ATOM   270   C  C     . TYR A 1 33  ? -5.189  -4.932  -18.356  1    25.938  ? 33   TYR A C     1 ? 
ATOM   271   O  O     . TYR A 1 33  ? -5.855  -5.383  -19.296  1    21.869  ? 33   TYR A O     1 ? 
ATOM   272   C  CB    . TYR A 1 33  ? -3.29   -3.707  -19.512  1    23.598  ? 33   TYR A CB    1 ? 
ATOM   273   C  CG    . TYR A 1 33  ? -1.843  -3.724  -20.032  1    21.245  ? 33   TYR A CG    1 ? 
ATOM   274   C  CD1   . TYR A 1 33  ? -0.772  -3.444  -19.197  1    24.564  ? 33   TYR A CD1   1 ? 
ATOM   275   C  CD2   . TYR A 1 33  ? -1.551  -3.982  -21.374  1    24.717  ? 33   TYR A CD2   1 ? 
ATOM   276   C  CE1   . TYR A 1 33  ? 0.541   -3.441  -19.66   1    26.892  ? 33   TYR A CE1   1 ? 
ATOM   277   C  CE2   . TYR A 1 33  ? -0.243  -4.034  -21.848  1    27.339  ? 33   TYR A CE2   1 ? 
ATOM   278   C  CZ    . TYR A 1 33  ? 0.805   -3.754  -20.98   1    29.714  ? 33   TYR A CZ    1 ? 
ATOM   279   O  OH    . TYR A 1 33  ? 2.105   -3.742  -21.382  1    30.609  ? 33   TYR A OH    1 ? 
ATOM   280   N  N     . LEU A 1 34  ? -5.694  -4.557  -17.169  1    21.123  ? 34   LEU A N     1 ? 
ATOM   281   C  CA    . LEU A 1 34  ? -7.106  -4.649  -16.843  1    25.61   ? 34   LEU A CA    1 ? 
ATOM   282   C  C     . LEU A 1 34  ? -7.597  -3.33   -16.23   1    24.589  ? 34   LEU A C     1 ? 
ATOM   283   O  O     . LEU A 1 34  ? -7.132  -2.922  -15.176  1    24.942  ? 34   LEU A O     1 ? 
ATOM   284   C  CB    . LEU A 1 34  ? -7.275  -5.827  -15.892  1    25.112  ? 34   LEU A CB    1 ? 
ATOM   285   C  CG    . LEU A 1 34  ? -8.7    -6.105  -15.393  1    29.556  ? 34   LEU A CG    1 ? 
ATOM   286   C  CD1   . LEU A 1 34  ? -9.616  -6.247  -16.582  1    31.307  ? 34   LEU A CD1   1 ? 
ATOM   287   C  CD2   . LEU A 1 34  ? -8.626  -7.402  -14.629  1    30.752  ? 34   LEU A CD2   1 ? 
ATOM   288   N  N     . ASP A 1 35  ? -8.494  -2.642  -16.933  1    19.887  ? 35   ASP A N     1 ? 
ATOM   289   C  CA    . ASP A 1 35  ? -9.226  -1.53   -16.38   1    24.976  ? 35   ASP A CA    1 ? 
ATOM   290   C  C     . ASP A 1 35  ? -10.447 -2.138  -15.698  1    24.606  ? 35   ASP A C     1 ? 
ATOM   291   O  O     . ASP A 1 35  ? -11.158 -2.87   -16.347  1    25.842  ? 35   ASP A O     1 ? 
ATOM   292   C  CB    . ASP A 1 35  ? -9.577  -0.566  -17.502  1    31.155  ? 35   ASP A CB    1 ? 
ATOM   293   C  CG    . ASP A 1 35  ? -10.451 0.613   -17.1    1    46.186  ? 35   ASP A CG    1 ? 
ATOM   294   O  OD1   . ASP A 1 35  ? -10.667 0.846   -15.869  1    50.097  ? 35   ASP A OD1   1 ? 
ATOM   295   O  OD2   . ASP A 1 35  ? -10.933 1.291   -18.028  1    72.186  ? 35   ASP A OD2   1 ? 
ATOM   296   N  N     . MET A 1 36  ? -10.68  -1.855  -14.416  1    20.078  ? 36   MET A N     1 ? 
ATOM   297   C  CA    A MET A 1 36  ? -11.556 -2.63   -13.55   0.5  20.344  ? 36   MET A CA    1 ? 
ATOM   298   C  CA    B MET A 1 36  ? -11.591 -2.699  -13.663  0.5  20.924  ? 36   MET A CA    1 ? 
ATOM   299   C  C     . MET A 1 36  ? -13.007 -2.111  -13.554  1    20.171  ? 36   MET A C     1 ? 
ATOM   300   O  O     . MET A 1 36  ? -13.898 -2.762  -13.022  1    19.408  ? 36   MET A O     1 ? 
ATOM   301   C  CB    A MET A 1 36  ? -11.067 -2.524  -12.094  0.5  19.306  ? 36   MET A CB    1 ? 
ATOM   302   C  CB    B MET A 1 36  ? -11.056 -2.914  -12.243  0.5  22.111  ? 36   MET A CB    1 ? 
ATOM   303   C  CG    A MET A 1 36  ? -9.793  -3.306  -11.803  0.5  24.041  ? 36   MET A CG    1 ? 
ATOM   304   C  CG    B MET A 1 36  ? -9.833  -3.821  -12.203  0.5  27.197  ? 36   MET A CG    1 ? 
ATOM   305   S  SD    A MET A 1 36  ? -10.182 -5.049  -12.065  0.5  22.699  ? 36   MET A SD    1 ? 
ATOM   306   S  SD    B MET A 1 36  ? -9.468  -4.069  -10.46   0.5  27.987  ? 36   MET A SD    1 ? 
ATOM   307   C  CE    A MET A 1 36  ? -11.338 -5.21   -10.698  0.5  24.887  ? 36   MET A CE    1 ? 
ATOM   308   C  CE    B MET A 1 36  ? -11.19  -4.024  -9.949   0.5  23.412  ? 36   MET A CE    1 ? 
ATOM   309   N  N     . ASN A 1 37  ? -13.235 -0.882  -14.013  1    18.367  ? 37   ASN A N     1 ? 
ATOM   310   C  CA    . ASN A 1 37  ? -14.523 -0.214  -13.781  1    20.8    ? 37   ASN A CA    1 ? 
ATOM   311   C  C     . ASN A 1 37  ? -15.717 -1.01   -14.343  1    18.71   ? 37   ASN A C     1 ? 
ATOM   312   O  O     . ASN A 1 37  ? -16.782 -1.051  -13.743  1    21.332  ? 37   ASN A O     1 ? 
ATOM   313   C  CB    . ASN A 1 37  ? -14.507 1.259   -14.204  1    17.208  ? 37   ASN A CB    1 ? 
ATOM   314   C  CG    . ASN A 1 37  ? -13.856 2.118   -13.142  1    25.388  ? 37   ASN A CG    1 ? 
ATOM   315   O  OD1   . ASN A 1 37  ? -12.659 1.929   -12.811  1    20.817  ? 37   ASN A OD1   1 ? 
ATOM   316   N  ND2   . ASN A 1 37  ? -14.63  3.052   -12.587  1    19.659  ? 37   ASN A ND2   1 ? 
ATOM   317   N  N     . GLY A 1 38  ? -15.581 -1.588  -15.53   1    20.16   ? 38   GLY A N     1 ? 
ATOM   318   C  CA    . GLY A 1 38  ? -16.691 -2.332  -16.105  1    22.187  ? 38   GLY A CA    1 ? 
ATOM   319   C  C     . GLY A 1 38  ? -17.034 -3.515  -15.209  1    22.976  ? 38   GLY A C     1 ? 
ATOM   320   O  O     . GLY A 1 38  ? -18.2   -3.813  -14.966  1    23.949  ? 38   GLY A O     1 ? 
ATOM   321   N  N     . ILE A 1 39  ? -15.993 -4.146  -14.668  1    19.568  ? 39   ILE A N     1 ? 
ATOM   322   C  CA    . ILE A 1 39  ? -16.148 -5.26   -13.752  1    18.47   ? 39   ILE A CA    1 ? 
ATOM   323   C  C     . ILE A 1 39  ? -16.895 -4.821  -12.502  1    18.489  ? 39   ILE A C     1 ? 
ATOM   324   O  O     . ILE A 1 39  ? -17.782 -5.524  -12.024  1    16.859  ? 39   ILE A O     1 ? 
ATOM   325   C  CB    . ILE A 1 39  ? -14.787 -5.935  -13.464  1    20.627  ? 39   ILE A CB    1 ? 
ATOM   326   C  CG1   . ILE A 1 39  ? -14.307 -6.702  -14.705  1    23.982  ? 39   ILE A CG1   1 ? 
ATOM   327   C  CG2   . ILE A 1 39  ? -14.869 -6.882  -12.265  1    19.798  ? 39   ILE A CG2   1 ? 
ATOM   328   C  CD1   . ILE A 1 39  ? -12.801 -7.001  -14.739  1    27.479  ? 39   ILE A CD1   1 ? 
ATOM   329   N  N     . ILE A 1 40  ? -16.545 -3.656  -11.961  1    16.694  ? 40   ILE A N     1 ? 
ATOM   330   C  CA    . ILE A 1 40  ? -17.176 -3.215  -10.727  1    17.237  ? 40   ILE A CA    1 ? 
ATOM   331   C  C     . ILE A 1 40  ? -18.674 -2.957  -10.982  1    19.654  ? 40   ILE A C     1 ? 
ATOM   332   O  O     . ILE A 1 40  ? -19.514 -3.268  -10.146  1    20.032  ? 40   ILE A O     1 ? 
ATOM   333   C  CB    . ILE A 1 40  ? -16.44  -1.978  -10.174  1    15.997  ? 40   ILE A CB    1 ? 
ATOM   334   C  CG1   . ILE A 1 40  ? -14.942 -2.317  -9.882   1    16.779  ? 40   ILE A CG1   1 ? 
ATOM   335   C  CG2   . ILE A 1 40  ? -17.125 -1.397  -8.923   1    15.667  ? 40   ILE A CG2   1 ? 
ATOM   336   C  CD1   . ILE A 1 40  ? -14.074 -1.053  -9.807   1    18.41   ? 40   ILE A CD1   1 ? 
ATOM   337   N  N     . HIS A 1 41  ? -19.006 -2.378  -12.131  1    20.728  ? 41   HIS A N     1 ? 
ATOM   338   C  CA    . HIS A 1 41  ? -20.409 -2.089  -12.427  1    21.988  ? 41   HIS A CA    1 ? 
ATOM   339   C  C     . HIS A 1 41  ? -21.164 -3.414  -12.581  1    23.221  ? 41   HIS A C     1 ? 
ATOM   340   O  O     . HIS A 1 41  ? -22.246 -3.527  -12.028  1    21.344  ? 41   HIS A O     1 ? 
ATOM   341   C  CB    . HIS A 1 41  ? -20.507 -1.282  -13.728  1    18.595  ? 41   HIS A CB    1 ? 
ATOM   342   C  CG    . HIS A 1 41  ? -20.257 0.163   -13.458  1    21.568  ? 41   HIS A CG    1 ? 
ATOM   343   N  ND1   . HIS A 1 41  ? -21.306 0.998   -13.11   1    18.821  ? 41   HIS A ND1   1 ? 
ATOM   344   C  CD2   . HIS A 1 41  ? -19.134 0.927   -13.481  1    17.79   ? 41   HIS A CD2   1 ? 
ATOM   345   C  CE1   . HIS A 1 41  ? -20.836 2.221   -12.895  1    18.181  ? 41   HIS A CE1   1 ? 
ATOM   346   N  NE2   . HIS A 1 41  ? -19.502 2.205   -13.105  1    19.525  ? 41   HIS A NE2   1 ? 
ATOM   347   N  N     . GLN A 1 42  ? -20.531 -4.406  -13.251  1    22.354  ? 42   GLN A N     1 ? 
ATOM   348   C  CA    . GLN A 1 42  ? -21.114 -5.719  -13.528  1    26.192  ? 42   GLN A CA    1 ? 
ATOM   349   C  C     . GLN A 1 42  ? -21.431 -6.462  -12.237  1    24.894  ? 42   GLN A C     1 ? 
ATOM   350   O  O     . GLN A 1 42  ? -22.509 -7.049  -12.113  1    27.956  ? 42   GLN A O     1 ? 
ATOM   351   C  CB    . GLN A 1 42  ? -20.296 -6.652  -14.43   1    31.761  ? 42   GLN A CB    1 ? 
ATOM   352   C  CG    . GLN A 1 42  ? -20.155 -6.221  -15.886  1    48.16   ? 42   GLN A CG    1 ? 
ATOM   353   C  CD    . GLN A 1 42  ? -19.208 -7.067  -16.732  1    56.73   ? 42   GLN A CD    1 ? 
ATOM   354   O  OE1   . GLN A 1 42  ? -18.127 -6.625  -17.159  1    49.746  ? 42   GLN A OE1   1 ? 
ATOM   355   N  NE2   . GLN A 1 42  ? -19.618 -8.297  -17.012  1    58.201  ? 42   GLN A NE2   1 ? 
ATOM   356   N  N     . CYS A 1 43  ? -20.547 -6.364  -11.244  1    21.782  ? 43   CYS A N     1 ? 
ATOM   357   C  CA    . CYS A 1 43  ? -20.689 -7.115  -10.001  1    19.862  ? 43   CYS A CA    1 ? 
ATOM   358   C  C     . CYS A 1 43  ? -21.601 -6.416  -9.001   1    19.692  ? 43   CYS A C     1 ? 
ATOM   359   O  O     . CYS A 1 43  ? -22.027 -7.059  -8.046   1    21.215  ? 43   CYS A O     1 ? 
ATOM   360   C  CB    . CYS A 1 43  ? -19.31  -7.374  -9.371   1    19.335  ? 43   CYS A CB    1 ? 
ATOM   361   S  SG    . CYS A 1 43  ? -18.232 -8.413  -10.42   1    21.799  ? 43   CYS A SG    1 ? 
ATOM   362   N  N     . SER A 1 44  ? -21.755 -5.074  -9.099   1    19.556  ? 44   SER A N     1 ? 
ATOM   363   C  CA    . SER A 1 44  ? -22.548 -4.335  -8.122   1    17.874  ? 44   SER A CA    1 ? 
ATOM   364   C  C     . SER A 1 44  ? -23.987 -4.104  -8.576   1    17.918  ? 44   SER A C     1 ? 
ATOM   365   O  O     . SER A 1 44  ? -24.862 -3.977  -7.715   1    16.118  ? 44   SER A O     1 ? 
ATOM   366   C  CB    . SER A 1 44  ? -21.944 -3.01   -7.735   1    18.969  ? 44   SER A CB    1 ? 
ATOM   367   O  OG    . SER A 1 44  ? -21.605 -2.301  -8.915   1    25.07   ? 44   SER A OG    1 ? 
ATOM   368   N  N     . HIS A 1 45  ? -24.235 -3.968  -9.885   1    17.265  ? 45   HIS A N     1 ? 
ATOM   369   C  CA    . HIS A 1 45  ? -25.615 -3.722  -10.305  1    20.787  ? 45   HIS A CA    1 ? 
ATOM   370   C  C     . HIS A 1 45  ? -25.881 -4.481  -11.595  1    20.96   ? 45   HIS A C     1 ? 
ATOM   371   O  O     . HIS A 1 45  ? -26.162 -3.874  -12.615  1    21.854  ? 45   HIS A O     1 ? 
ATOM   372   C  CB    . HIS A 1 45  ? -25.975 -2.214  -10.342  1    19.489  ? 45   HIS A CB    1 ? 
ATOM   373   C  CG    . HIS A 1 45  ? -25.234 -1.343  -11.323  1    22.241  ? 45   HIS A CG    1 ? 
ATOM   374   N  ND1   . HIS A 1 45  ? -25.857 -0.717  -12.389  1    19.136  ? 45   HIS A ND1   1 ? 
ATOM   375   C  CD2   . HIS A 1 45  ? -23.914 -0.947  -11.365  1    17.846  ? 45   HIS A CD2   1 ? 
ATOM   376   C  CE1   . HIS A 1 45  ? -24.952 0.02    -13.064  1    23.412  ? 45   HIS A CE1   1 ? 
ATOM   377   N  NE2   . HIS A 1 45  ? -23.752 -0.099  -12.461  1    18.707  ? 45   HIS A NE2   1 ? 
ATOM   378   N  N     . PRO A 1 46  ? -25.836 -5.839  -11.605  1    24.163  ? 46   PRO A N     1 ? 
ATOM   379   C  CA    . PRO A 1 46  ? -26.082 -6.59   -12.832  1    25.146  ? 46   PRO A CA    1 ? 
ATOM   380   C  C     . PRO A 1 46  ? -27.529 -6.532  -13.34   1    27.201  ? 46   PRO A C     1 ? 
ATOM   381   O  O     . PRO A 1 46  ? -27.757 -6.72   -14.522  1    38.424  ? 46   PRO A O     1 ? 
ATOM   382   C  CB    . PRO A 1 46  ? -25.636 -8.026  -12.525  1    21.381  ? 46   PRO A CB    1 ? 
ATOM   383   C  CG    . PRO A 1 46  ? -25.806 -8.125  -11.036  1    24.002  ? 46   PRO A CG    1 ? 
ATOM   384   C  CD    . PRO A 1 46  ? -25.582 -6.705  -10.456  1    23.17   ? 46   PRO A CD    1 ? 
ATOM   385   N  N     . ASN A 1 47  ? -28.492 -6.216  -12.482  1    28.4    ? 47   ASN A N     1 ? 
ATOM   386   C  CA    . ASN A 1 47  ? -29.898 -6.443  -12.83   1    30.138  ? 47   ASN A CA    1 ? 
ATOM   387   C  C     . ASN A 1 47  ? -30.737 -5.18   -12.591  1    28.707  ? 47   ASN A C     1 ? 
ATOM   388   O  O     . ASN A 1 47  ? -31.585 -5.144  -11.692  1    26.948  ? 47   ASN A O     1 ? 
ATOM   389   C  CB    . ASN A 1 47  ? -30.445 -7.522  -11.9    1    30.63   ? 47   ASN A CB    1 ? 
ATOM   390   C  CG    . ASN A 1 47  ? -29.748 -8.857  -12.094  1    38.161  ? 47   ASN A CG    1 ? 
ATOM   391   O  OD1   . ASN A 1 47  ? -29.427 -9.54   -11.114  1    42.763  ? 47   ASN A OD1   1 ? 
ATOM   392   N  ND2   . ASN A 1 47  ? -29.558 -9.281  -13.337  1    38.124  ? 47   ASN A ND2   1 ? 
ATOM   393   N  N     . ASP A 1 48  ? -30.469 -4.124  -13.352  1    26.012  ? 48   ASP A N     1 ? 
ATOM   394   C  CA    . ASP A 1 48  ? -31.049 -2.841  -12.995  1    28.977  ? 48   ASP A CA    1 ? 
ATOM   395   C  C     . ASP A 1 48  ? -32.556 -2.803  -13.284  1    30.083  ? 48   ASP A C     1 ? 
ATOM   396   O  O     . ASP A 1 48  ? -33.249 -1.969  -12.719  1    29.443  ? 48   ASP A O     1 ? 
ATOM   397   C  CB    . ASP A 1 48  ? -30.319 -1.673  -13.631  1    29.685  ? 48   ASP A CB    1 ? 
ATOM   398   C  CG    . ASP A 1 48  ? -29.032 -1.246  -12.925  1    37.051  ? 48   ASP A CG    1 ? 
ATOM   399   O  OD1   . ASP A 1 48  ? -28.912 -1.447  -11.676  1    37.668  ? 48   ASP A OD1   1 ? 
ATOM   400   O  OD2   . ASP A 1 48  ? -28.145 -0.741  -13.639  1    33.795  ? 48   ASP A OD2   1 ? 
ATOM   401   N  N     . ASP A 1 49  ? -33.064 -3.724  -14.097  1    26.86   ? 49   ASP A N     1 ? 
ATOM   402   C  CA    . ASP A 1 49  ? -34.5   -3.757  -14.335  1    30.742  ? 49   ASP A CA    1 ? 
ATOM   403   C  C     . ASP A 1 49  ? -35.265 -4.39   -13.185  1    30.872  ? 49   ASP A C     1 ? 
ATOM   404   O  O     . ASP A 1 49  ? -36.492 -4.322  -13.162  1    37.741  ? 49   ASP A O     1 ? 
ATOM   405   C  CB    . ASP A 1 49  ? -34.868 -4.426  -15.636  1    35.013  ? 49   ASP A CB    1 ? 
ATOM   406   C  CG    . ASP A 1 49  ? -34.324 -3.733  -16.866  1    40.718  ? 49   ASP A CG    1 ? 
ATOM   407   O  OD1   . ASP A 1 49  ? -34.356 -2.48   -16.909  1    41.672  ? 49   ASP A OD1   1 ? 
ATOM   408   O  OD2   . ASP A 1 49  ? -33.888 -4.47   -17.773  1    53.417  ? 49   ASP A OD2   1 ? 
ATOM   409   N  N     . ASP A 1 50  ? -34.562 -4.934  -12.198  1    30.484  ? 50   ASP A N     1 ? 
ATOM   410   C  CA    . ASP A 1 50  ? -35.247 -5.485  -11.044  1    29.77   ? 50   ASP A CA    1 ? 
ATOM   411   C  C     . ASP A 1 50  ? -35.117 -4.508  -9.88    1    31.728  ? 50   ASP A C     1 ? 
ATOM   412   O  O     . ASP A 1 50  ? -34.081 -4.474  -9.226   1    28.953  ? 50   ASP A O     1 ? 
ATOM   413   C  CB    . ASP A 1 50  ? -34.772 -6.901  -10.716  1    33.403  ? 50   ASP A CB    1 ? 
ATOM   414   C  CG    . ASP A 1 50  ? -35.298 -7.491  -9.415   1    35.761  ? 50   ASP A CG    1 ? 
ATOM   415   O  OD1   . ASP A 1 50  ? -36.345 -7.014  -8.901   1    38.825  ? 50   ASP A OD1   1 ? 
ATOM   416   O  OD2   . ASP A 1 50  ? -34.644 -8.398  -8.875   1    43.229  ? 50   ASP A OD2   1 ? 
ATOM   417   N  N     . VAL A 1 51  ? -36.205 -3.789  -9.552   1    29.812  ? 51   VAL A N     1 ? 
ATOM   418   C  CA    . VAL A 1 51  ? -36.13  -2.722  -8.563   1    25.388  ? 51   VAL A CA    1 ? 
ATOM   419   C  C     . VAL A 1 51  ? -36.028 -3.341  -7.169   1    22.558  ? 51   VAL A C     1 ? 
ATOM   420   O  O     . VAL A 1 51  ? -35.671 -2.669  -6.204   1    26.302  ? 51   VAL A O     1 ? 
ATOM   421   C  CB    . VAL A 1 51  ? -37.349 -1.778  -8.699   1    26.838  ? 51   VAL A CB    1 ? 
ATOM   422   C  CG1   . VAL A 1 51  ? -37.466 -1.206  -10.109  1    25.932  ? 51   VAL A CG1   1 ? 
ATOM   423   C  CG2   . VAL A 1 51  ? -38.667 -2.454  -8.307   1    28.853  ? 51   VAL A CG2   1 ? 
ATOM   424   N  N     . HIS A 1 52  ? -36.28  -4.651  -7.072   1    21.732  ? 52   HIS A N     1 ? 
ATOM   425   C  CA    . HIS A 1 52  ? -36.187 -5.347  -5.8     1    25.475  ? 52   HIS A CA    1 ? 
ATOM   426   C  C     . HIS A 1 52  ? -34.761 -5.818  -5.482   1    26.871  ? 52   HIS A C     1 ? 
ATOM   427   O  O     . HIS A 1 52  ? -34.447 -6.109  -4.327   1    28      ? 52   HIS A O     1 ? 
ATOM   428   C  CB    . HIS A 1 52  ? -37.177 -6.529  -5.741   1    29.645  ? 52   HIS A CB    1 ? 
ATOM   429   C  CG    . HIS A 1 52  ? -38.591 -6.083  -5.999   1    32.739  ? 52   HIS A CG    1 ? 
ATOM   430   N  ND1   . HIS A 1 52  ? -39.419 -5.749  -4.947   1    34.232  ? 52   HIS A ND1   1 ? 
ATOM   431   C  CD2   . HIS A 1 52  ? -39.315 -5.88   -7.141   1    30.856  ? 52   HIS A CD2   1 ? 
ATOM   432   C  CE1   . HIS A 1 52  ? -40.609 -5.38   -5.429   1    32.371  ? 52   HIS A CE1   1 ? 
ATOM   433   N  NE2   . HIS A 1 52  ? -40.575 -5.441  -6.751   1    28.281  ? 52   HIS A NE2   1 ? 
ATOM   434   N  N     . PHE A 1 53  ? -33.891 -5.886  -6.481   1    25.479  ? 53   PHE A N     1 ? 
ATOM   435   C  CA    . PHE A 1 53  ? -32.588 -6.521  -6.262   1    24.387  ? 53   PHE A CA    1 ? 
ATOM   436   C  C     . PHE A 1 53  ? -31.793 -5.771  -5.194   1    24.589  ? 53   PHE A C     1 ? 
ATOM   437   O  O     . PHE A 1 53  ? -31.668 -4.534  -5.225   1    24.837  ? 53   PHE A O     1 ? 
ATOM   438   C  CB    . PHE A 1 53  ? -31.849 -6.599  -7.61    1    25.386  ? 53   PHE A CB    1 ? 
ATOM   439   C  CG    . PHE A 1 53  ? -30.45  -7.186  -7.506   1    28.746  ? 53   PHE A CG    1 ? 
ATOM   440   C  CD1   . PHE A 1 53  ? -30.261 -8.568  -7.387   1    35.801  ? 53   PHE A CD1   1 ? 
ATOM   441   C  CD2   . PHE A 1 53  ? -29.319 -6.368  -7.488   1    26.677  ? 53   PHE A CD2   1 ? 
ATOM   442   C  CE1   . PHE A 1 53  ? -28.972 -9.113  -7.337   1    37.035  ? 53   PHE A CE1   1 ? 
ATOM   443   C  CE2   . PHE A 1 53  ? -28.039 -6.921  -7.408   1    27.656  ? 53   PHE A CE2   1 ? 
ATOM   444   C  CZ    . PHE A 1 53  ? -27.869 -8.287  -7.339   1    29.661  ? 53   PHE A CZ    1 ? 
ATOM   445   N  N     . ARG A 1 54  ? -31.247 -6.529  -4.231   1    23.98   ? 54   ARG A N     1 ? 
ATOM   446   C  CA    . ARG A 1 54  ? -30.376 -5.98   -3.205   1    25.902  ? 54   ARG A CA    1 ? 
ATOM   447   C  C     . ARG A 1 54  ? -29.123 -6.855  -3.132   1    33.334  ? 54   ARG A C     1 ? 
ATOM   448   O  O     . ARG A 1 54  ? -29.206 -8.031  -3.48    1    29.566  ? 54   ARG A O     1 ? 
ATOM   449   C  CB    . ARG A 1 54  ? -31.003 -5.963  -1.808   1    27.736  ? 54   ARG A CB    1 ? 
ATOM   450   C  CG    . ARG A 1 54  ? -32.188 -4.997  -1.751   1    31.101  ? 54   ARG A CG    1 ? 
ATOM   451   C  CD    . ARG A 1 54  ? -31.734 -3.562  -2.203   1    26.832  ? 54   ARG A CD    1 ? 
ATOM   452   N  NE    . ARG A 1 54  ? -32.803 -2.585  -1.97    1    23.044  ? 54   ARG A NE    1 ? 
ATOM   453   C  CZ    . ARG A 1 54  ? -33.63  -2.159  -2.925   1    24.216  ? 54   ARG A CZ    1 ? 
ATOM   454   N  NH1   . ARG A 1 54  ? -34.592 -1.313  -2.605   1    24.537  ? 54   ARG A NH1   1 ? 
ATOM   455   N  NH2   . ARG A 1 54  ? -33.497 -2.556  -4.178   1    19.452  ? 54   ARG A NH2   1 ? 
ATOM   456   N  N     . ILE A 1 55  ? -27.983 -6.273  -2.699   1    27.021  ? 55   ILE A N     1 ? 
ATOM   457   C  CA    . ILE A 1 55  ? -26.723 -7.017  -2.687   1    29.439  ? 55   ILE A CA    1 ? 
ATOM   458   C  C     . ILE A 1 55  ? -25.796 -6.394  -1.65    1    26.569  ? 55   ILE A C     1 ? 
ATOM   459   O  O     . ILE A 1 55  ? -25.763 -5.175  -1.49    1    27.63   ? 55   ILE A O     1 ? 
ATOM   460   C  CB    . ILE A 1 55  ? -26.103 -7.111  -4.098   1    29.461  ? 55   ILE A CB    1 ? 
ATOM   461   C  CG1   . ILE A 1 55  ? -25.006 -8.185  -4.186   1    28.822  ? 55   ILE A CG1   1 ? 
ATOM   462   C  CG2   . ILE A 1 55  ? -25.65  -5.737  -4.607   1    26.543  ? 55   ILE A CG2   1 ? 
ATOM   463   C  CD1   . ILE A 1 55  ? -24.307 -8.26   -5.526   1    25.025  ? 55   ILE A CD1   1 ? 
ATOM   464   N  N     . SER A 1 56  ? -25.188 -7.24   -0.82    1    23.048  ? 56   SER A N     1 ? 
ATOM   465   C  CA    . SER A 1 56  ? -24.33  -6.723  0.237    1    24.448  ? 56   SER A CA    1 ? 
ATOM   466   C  C     . SER A 1 56  ? -22.951 -6.413  -0.36    1    21.01   ? 56   SER A C     1 ? 
ATOM   467   O  O     . SER A 1 56  ? -22.592 -6.937  -1.416   1    22.005  ? 56   SER A O     1 ? 
ATOM   468   C  CB    . SER A 1 56  ? -24.228 -7.754  1.328    1    28.299  ? 56   SER A CB    1 ? 
ATOM   469   O  OG    . SER A 1 56  ? -23.636 -8.909  0.746    1    31.344  ? 56   SER A OG    1 ? 
ATOM   470   N  N     . ASP A 1 57  ? -22.204 -5.499  0.267    1    22.443  ? 57   ASP A N     1 ? 
ATOM   471   C  CA    . ASP A 1 57  ? -20.88  -5.146  -0.219   1    24.146  ? 57   ASP A CA    1 ? 
ATOM   472   C  C     . ASP A 1 57  ? -19.936 -6.356  -0.22    1    24.386  ? 57   ASP A C     1 ? 
ATOM   473   O  O     . ASP A 1 57  ? -19.063 -6.425  -1.086   1    23.428  ? 57   ASP A O     1 ? 
ATOM   474   C  CB    . ASP A 1 57  ? -20.256 -4.05   0.631    1    24.829  ? 57   ASP A CB    1 ? 
ATOM   475   C  CG    . ASP A 1 57  ? -20.803 -2.644  0.4      1    27.988  ? 57   ASP A CG    1 ? 
ATOM   476   O  OD1   . ASP A 1 57  ? -21.669 -2.478  -0.501   1    25.546  ? 57   ASP A OD1   1 ? 
ATOM   477   O  OD2   . ASP A 1 57  ? -20.341 -1.716  1.101    1    30.717  ? 57   ASP A OD2   1 ? 
ATOM   478   N  N     . ASP A 1 58  ? -20.053 -7.275  0.757    1    21.712  ? 58   ASP A N     1 ? 
ATOM   479   C  CA    . ASP A 1 58  ? -19.07  -8.363  0.793    1    26.789  ? 58   ASP A CA    1 ? 
ATOM   480   C  C     . ASP A 1 58  ? -19.326 -9.295  -0.381   1    26.479  ? 58   ASP A C     1 ? 
ATOM   481   O  O     . ASP A 1 58  ? -18.422 -9.955  -0.912   1    22.396  ? 58   ASP A O     1 ? 
ATOM   482   C  CB    . ASP A 1 58  ? -19.105 -9.171  2.085    1    30.645  ? 58   ASP A CB    1 ? 
ATOM   483   C  CG    . ASP A 1 58  ? -20.498 -9.565  2.57     1    35.367  ? 58   ASP A CG    1 ? 
ATOM   484   O  OD1   . ASP A 1 58  ? -21.313 -8.646  2.799    1    32.593  ? 58   ASP A OD1   1 ? 
ATOM   485   O  OD2   . ASP A 1 58  ? -20.777 -10.774 2.635    1    37.655  ? 58   ASP A OD2   1 ? 
ATOM   486   N  N     . LYS A 1 59  ? -20.602 -9.357  -0.781   1    19.659  ? 59   LYS A N     1 ? 
ATOM   487   C  CA    . LYS A 1 59  ? -20.933 -10.135 -1.953   1    19.988  ? 59   LYS A CA    1 ? 
ATOM   488   C  C     . LYS A 1 59  ? -20.342 -9.465  -3.195   1    22.157  ? 59   LYS A C     1 ? 
ATOM   489   O  O     . LYS A 1 59  ? -19.824 -10.135 -4.09    1    21.28   ? 59   LYS A O     1 ? 
ATOM   490   C  CB    . LYS A 1 59  ? -22.466 -10.294 -2.02    1    20.815  ? 59   LYS A CB    1 ? 
ATOM   491   C  CG    . LYS A 1 59  ? -22.908 -10.944 -3.286   1    20.935  ? 59   LYS A CG    1 ? 
ATOM   492   C  CD    . LYS A 1 59  ? -22.384 -12.355 -3.597   1    31.744  ? 59   LYS A CD    1 ? 
ATOM   493   C  CE    . LYS A 1 59  ? -22.996 -12.945 -4.874   1    31.696  ? 59   LYS A CE    1 ? 
ATOM   494   N  NZ    . LYS A 1 59  ? -22.289 -14.144 -5.333   1    31.98   ? 59   LYS A NZ    1 ? 
ATOM   495   N  N     . ILE A 1 60  ? -20.473 -8.135  -3.304   1    19.579  ? 60   ILE A N     1 ? 
ATOM   496   C  CA    . ILE A 1 60  ? -19.966 -7.46   -4.495   1    19.361  ? 60   ILE A CA    1 ? 
ATOM   497   C  C     . ILE A 1 60  ? -18.439 -7.701  -4.622   1    16.023  ? 60   ILE A C     1 ? 
ATOM   498   O  O     . ILE A 1 60  ? -17.897 -7.834  -5.721   1    16.35   ? 60   ILE A O     1 ? 
ATOM   499   C  CB    . ILE A 1 60  ? -20.235 -5.943  -4.379   1    20.871  ? 60   ILE A CB    1 ? 
ATOM   500   C  CG1   . ILE A 1 60  ? -21.74  -5.6    -4.444   1    20.972  ? 60   ILE A CG1   1 ? 
ATOM   501   C  CG2   . ILE A 1 60  ? -19.42  -5.172  -5.435   1    19.315  ? 60   ILE A CG2   1 ? 
ATOM   502   C  CD1   . ILE A 1 60  ? -21.987 -4.122  -4.192   1    21.025  ? 60   ILE A CD1   1 ? 
ATOM   503   N  N     . PHE A 1 61  ? -17.748 -7.663  -3.494   1    16.752  ? 61   PHE A N     1 ? 
ATOM   504   C  CA    . PHE A 1 61  ? -16.29  -7.764  -3.453   1    17.74   ? 61   PHE A CA    1 ? 
ATOM   505   C  C     . PHE A 1 61  ? -15.871 -9.184  -3.815   1    19.394  ? 61   PHE A C     1 ? 
ATOM   506   O  O     . PHE A 1 61  ? -14.99  -9.393  -4.661   1    21.487  ? 61   PHE A O     1 ? 
ATOM   507   C  CB    . PHE A 1 61  ? -15.852 -7.44   -2.021   1    16.528  ? 61   PHE A CB    1 ? 
ATOM   508   C  CG    . PHE A 1 61  ? -16.068 -6.007  -1.542   1    17.091  ? 61   PHE A CG    1 ? 
ATOM   509   C  CD1   . PHE A 1 61  ? -16.282 -4.97   -2.441   1    16.683  ? 61   PHE A CD1   1 ? 
ATOM   510   C  CD2   . PHE A 1 61  ? -16.151 -5.731  -0.179   1    15.936  ? 61   PHE A CD2   1 ? 
ATOM   511   C  CE1   . PHE A 1 61  ? -16.55  -3.683  -1.969   1    17.355  ? 61   PHE A CE1   1 ? 
ATOM   512   C  CE2   . PHE A 1 61  ? -16.367 -4.437  0.284    1    19.645  ? 61   PHE A CE2   1 ? 
ATOM   513   C  CZ    . PHE A 1 61  ? -16.596 -3.414  -0.631   1    17.898  ? 61   PHE A CZ    1 ? 
ATOM   514   N  N     . THR A 1 62  ? -16.527 -10.17  -3.176   1    20.037  ? 62   THR A N     1 ? 
ATOM   515   C  CA    . THR A 1 62  ? -16.366 -11.591 -3.539   1    19.508  ? 62   THR A CA    1 ? 
ATOM   516   C  C     . THR A 1 62  ? -16.518 -11.756 -5.037   1    19.977  ? 62   THR A C     1 ? 
ATOM   517   O  O     . THR A 1 62  ? -15.714 -12.416 -5.688   1    24.356  ? 62   THR A O     1 ? 
ATOM   518   C  CB    . THR A 1 62  ? -17.384 -12.476 -2.802   1    22.092  ? 62   THR A CB    1 ? 
ATOM   519   O  OG1   . THR A 1 62  ? -16.897 -12.397 -1.472   1    22.906  ? 62   THR A OG1   1 ? 
ATOM   520   C  CG2   . THR A 1 62  ? -17.368 -13.933 -3.259   1    22.971  ? 62   THR A CG2   1 ? 
ATOM   521   N  N     . ASP A 1 63  ? -17.585 -11.202 -5.629   1    22.008  ? 63   ASP A N     1 ? 
ATOM   522   C  CA    . ASP A 1 63  ? -17.739 -11.39  -7.069   1    20.811  ? 63   ASP A CA    1 ? 
ATOM   523   C  C     . ASP A 1 63  ? -16.645 -10.662 -7.865   1    18.199  ? 63   ASP A C     1 ? 
ATOM   524   O  O     . ASP A 1 63  ? -16.283 -11.099 -8.964   1    18.359  ? 63   ASP A O     1 ? 
ATOM   525   C  CB    . ASP A 1 63  ? -19.1   -10.887 -7.555   1    23.054  ? 63   ASP A CB    1 ? 
ATOM   526   C  CG    . ASP A 1 63  ? -20.296 -11.772 -7.188   1    30.624  ? 63   ASP A CG    1 ? 
ATOM   527   O  OD1   . ASP A 1 63  ? -20.063 -12.887 -6.69    1    27.839  ? 63   ASP A OD1   1 ? 
ATOM   528   O  OD2   . ASP A 1 63  ? -21.452 -11.312 -7.338   1    29.076  ? 63   ASP A OD2   1 ? 
ATOM   529   N  N     . ILE A 1 64  ? -16.208 -9.487  -7.399   1    18.075  ? 64   ILE A N     1 ? 
ATOM   530   C  CA    . ILE A 1 64  ? -15.105 -8.821  -8.114   1    20.368  ? 64   ILE A CA    1 ? 
ATOM   531   C  C     . ILE A 1 64  ? -13.842 -9.694  -8.035   1    17.873  ? 64   ILE A C     1 ? 
ATOM   532   O  O     . ILE A 1 64  ? -13.144 -9.854  -9.039   1    20.322  ? 64   ILE A O     1 ? 
ATOM   533   C  CB    . ILE A 1 64  ? -14.828 -7.375  -7.635   1    21.244  ? 64   ILE A CB    1 ? 
ATOM   534   C  CG1   . ILE A 1 64  ? -16.025 -6.419  -7.972   1    20.679  ? 64   ILE A CG1   1 ? 
ATOM   535   C  CG2   . ILE A 1 64  ? -13.519 -6.841  -8.247   1    18.154  ? 64   ILE A CG2   1 ? 
ATOM   536   C  CD1   . ILE A 1 64  ? -16.109 -5.177  -7.063   1    22.313  ? 64   ILE A CD1   1 ? 
ATOM   537   N  N     . PHE A 1 65  ? -13.565 -10.238 -6.851   1    19.956  ? 65   PHE A N     1 ? 
ATOM   538   C  CA    . PHE A 1 65  ? -12.384 -11.07  -6.633   1    22.468  ? 65   PHE A CA    1 ? 
ATOM   539   C  C     . PHE A 1 65  ? -12.427 -12.271 -7.571   1    24.37   ? 65   PHE A C     1 ? 
ATOM   540   O  O     . PHE A 1 65  ? -11.434 -12.59  -8.251   1    20.429  ? 65   PHE A O     1 ? 
ATOM   541   C  CB    . PHE A 1 65  ? -12.3   -11.657 -5.222   1    17.457  ? 65   PHE A CB    1 ? 
ATOM   542   C  CG    . PHE A 1 65  ? -12.025 -10.67  -4.107   1    21.235  ? 65   PHE A CG    1 ? 
ATOM   543   C  CD1   . PHE A 1 65  ? -11.657 -9.346  -4.384   1    19.858  ? 65   PHE A CD1   1 ? 
ATOM   544   C  CD2   . PHE A 1 65  ? -12.108 -11.066 -2.777   1    21.133  ? 65   PHE A CD2   1 ? 
ATOM   545   C  CE1   . PHE A 1 65  ? -11.42  -8.442  -3.376   1    18.246  ? 65   PHE A CE1   1 ? 
ATOM   546   C  CE2   . PHE A 1 65  ? -11.865 -10.141 -1.746   1    21.135  ? 65   PHE A CE2   1 ? 
ATOM   547   C  CZ    . PHE A 1 65  ? -11.524 -8.829  -2.049   1    20.058  ? 65   PHE A CZ    1 ? 
ATOM   548   N  N     . HIS A 1 66  ? -13.627 -12.892 -7.657   1    21.688  ? 66   HIS A N     1 ? 
ATOM   549   C  CA    . HIS A 1 66  ? -13.806 -14.036 -8.534   1    23.402  ? 66   HIS A CA    1 ? 
ATOM   550   C  C     . HIS A 1 66  ? -13.517 -13.687 -9.997   1    23.259  ? 66   HIS A C     1 ? 
ATOM   551   O  O     . HIS A 1 66  ? -12.869 -14.442 -10.729  1    24.333  ? 66   HIS A O     1 ? 
ATOM   552   C  CB    . HIS A 1 66  ? -15.16  -14.721 -8.244   1    29.356  ? 66   HIS A CB    1 ? 
ATOM   553   C  CG    . HIS A 1 66  ? -15.326 -15.924 -9.086   1    44.421  ? 66   HIS A CG    1 ? 
ATOM   554   N  ND1   . HIS A 1 66  ? -16.151 -15.976 -10.197  1    53.941  ? 66   HIS A ND1   1 ? 
ATOM   555   C  CD2   . HIS A 1 66  ? -14.717 -17.128 -8.99    1    47.7    ? 66   HIS A CD2   1 ? 
ATOM   556   C  CE1   . HIS A 1 66  ? -16.044 -17.182 -10.746  1    57.134  ? 66   HIS A CE1   1 ? 
ATOM   557   N  NE2   . HIS A 1 66  ? -15.183 -17.895 -10.024  1    50.715  ? 66   HIS A NE2   1 ? 
ATOM   558   N  N     . TYR A 1 67  ? -14.051 -12.567 -10.484  1    23.736  ? 67   TYR A N     1 ? 
ATOM   559   C  CA    . TYR A 1 67  ? -13.846 -12.178 -11.878  1    23.452  ? 67   TYR A CA    1 ? 
ATOM   560   C  C     . TYR A 1 67  ? -12.343 -12.065 -12.196  1    23.592  ? 67   TYR A C     1 ? 
ATOM   561   O  O     . TYR A 1 67  ? -11.872 -12.485 -13.25   1    23.251  ? 67   TYR A O     1 ? 
ATOM   562   C  CB    . TYR A 1 67  ? -14.51  -10.804 -12.062  1    23.759  ? 67   TYR A CB    1 ? 
ATOM   563   C  CG    . TYR A 1 67  ? -15.21  -10.63  -13.391  1    28.414  ? 67   TYR A CG    1 ? 
ATOM   564   C  CD1   . TYR A 1 67  ? -14.498 -10.658 -14.584  1    29.74   ? 67   TYR A CD1   1 ? 
ATOM   565   C  CD2   . TYR A 1 67  ? -16.59  -10.462 -13.451  1    32.804  ? 67   TYR A CD2   1 ? 
ATOM   566   C  CE1   . TYR A 1 67  ? -15.135 -10.52  -15.805  1    35.722  ? 67   TYR A CE1   1 ? 
ATOM   567   C  CE2   . TYR A 1 67  ? -17.234 -10.318 -14.673  1    42.388  ? 67   TYR A CE2   1 ? 
ATOM   568   C  CZ    . TYR A 1 67  ? -16.508 -10.345 -15.852  1    41.382  ? 67   TYR A CZ    1 ? 
ATOM   569   O  OH    . TYR A 1 67  ? -17.13  -10.211 -17.072  1    55.537  ? 67   TYR A OH    1 ? 
ATOM   570   N  N     . LEU A 1 68  ? -11.59  -11.444 -11.28   1    24.959  ? 68   LEU A N     1 ? 
ATOM   571   C  CA    . LEU A 1 68  ? -10.171 -11.153 -11.44   1    24.635  ? 68   LEU A CA    1 ? 
ATOM   572   C  C     . LEU A 1 68  ? -9.393  -12.453 -11.42   1    20.548  ? 68   LEU A C     1 ? 
ATOM   573   O  O     . LEU A 1 68  ? -8.531  -12.658 -12.262  1    25.838  ? 68   LEU A O     1 ? 
ATOM   574   C  CB    . LEU A 1 68  ? -9.652  -10.293 -10.284  1    26.592  ? 68   LEU A CB    1 ? 
ATOM   575   C  CG    . LEU A 1 68  ? -10.165 -8.861  -10.217  1    28.422  ? 68   LEU A CG    1 ? 
ATOM   576   C  CD1   . LEU A 1 68  ? -9.71   -8.168  -8.901   1    27.234  ? 68   LEU A CD1   1 ? 
ATOM   577   C  CD2   . LEU A 1 68  ? -9.602  -8.17   -11.434  1    29.694  ? 68   LEU A CD2   1 ? 
ATOM   578   N  N     . GLU A 1 69  ? -9.685  -13.286 -10.427  1    19.558  ? 69   GLU A N     1 ? 
ATOM   579   C  CA    . GLU A 1 69  ? -9.057  -14.586 -10.298  1    24.181  ? 69   GLU A CA    1 ? 
ATOM   580   C  C     . GLU A 1 69  ? -9.224  -15.406 -11.584  1    26.747  ? 69   GLU A C     1 ? 
ATOM   581   O  O     . GLU A 1 69  ? -8.259  -15.982 -12.107  1    23.758  ? 69   GLU A O     1 ? 
ATOM   582   C  CB    . GLU A 1 69  ? -9.554  -15.171 -8.986   1    27.645  ? 69   GLU A CB    1 ? 
ATOM   583   C  CG    . GLU A 1 69  ? -9.121  -16.618 -8.756   1    42.223  ? 69   GLU A CG    1 ? 
ATOM   584   C  CD    . GLU A 1 69  ? -9.422  -16.92  -7.306   1    49.304  ? 69   GLU A CD    1 ? 
ATOM   585   O  OE1   . GLU A 1 69  ? -10.621 -16.954 -6.942   1    62.129  ? 69   GLU A OE1   1 ? 
ATOM   586   O  OE2   . GLU A 1 69  ? -8.456  -17.048 -6.533   1    51.127  ? 69   GLU A OE2   1 ? 
ATOM   587   N  N     . VAL A 1 70  ? -10.421 -15.368 -12.165  1    23.925  ? 70   VAL A N     1 ? 
ATOM   588   C  CA    . VAL A 1 70  ? -10.686 -16.155 -13.354  1    23.637  ? 70   VAL A CA    1 ? 
ATOM   589   C  C     . VAL A 1 70  ? -9.942  -15.586 -14.552  1    22.943  ? 70   VAL A C     1 ? 
ATOM   590   O  O     . VAL A 1 70  ? -9.323  -16.33  -15.29   1    23.805  ? 70   VAL A O     1 ? 
ATOM   591   C  CB    . VAL A 1 70  ? -12.212 -16.263 -13.602  1    26.289  ? 70   VAL A CB    1 ? 
ATOM   592   C  CG1   . VAL A 1 70  ? -12.551 -16.798 -14.982  1    28.479  ? 70   VAL A CG1   1 ? 
ATOM   593   C  CG2   . VAL A 1 70  ? -12.866 -17.125 -12.533  1    27.904  ? 70   VAL A CG2   1 ? 
ATOM   594   N  N     . LEU A 1 71  ? -9.995  -14.277 -14.787  1    22.116  ? 71   LEU A N     1 ? 
ATOM   595   C  CA    . LEU A 1 71  ? -9.267  -13.709 -15.912  1    21.211  ? 71   LEU A CA    1 ? 
ATOM   596   C  C     . LEU A 1 71  ? -7.756  -13.973 -15.774  1    26.853  ? 71   LEU A C     1 ? 
ATOM   597   O  O     . LEU A 1 71  ? -7.043  -14.235 -16.751  1    25.95   ? 71   LEU A O     1 ? 
ATOM   598   C  CB    . LEU A 1 71  ? -9.543  -12.203 -15.935  1    23.251  ? 71   LEU A CB    1 ? 
ATOM   599   C  CG    . LEU A 1 71  ? -10.975 -11.793 -16.315  1    27.987  ? 71   LEU A CG    1 ? 
ATOM   600   C  CD1   . LEU A 1 71  ? -11.056 -10.273 -16.49   1    25.013  ? 71   LEU A CD1   1 ? 
ATOM   601   C  CD2   . LEU A 1 71  ? -11.512 -12.525 -17.565  1    27.72   ? 71   LEU A CD2   1 ? 
ATOM   602   N  N     . PHE A 1 72  ? -7.223  -13.828 -14.559  1    24.295  ? 72   PHE A N     1 ? 
ATOM   603   C  CA    . PHE A 1 72  ? -5.79   -14.034 -14.386  1    24.122  ? 72   PHE A CA    1 ? 
ATOM   604   C  C     . PHE A 1 72  ? -5.427  -15.501 -14.657  1    22.952  ? 72   PHE A C     1 ? 
ATOM   605   O  O     . PHE A 1 72  ? -4.434  -15.817 -15.313  1    26.703  ? 72   PHE A O     1 ? 
ATOM   606   C  CB    . PHE A 1 72  ? -5.382  -13.705 -12.945  1    23.18   ? 72   PHE A CB    1 ? 
ATOM   607   C  CG    . PHE A 1 72  ? -3.865  -13.633 -12.795  1    22.805  ? 72   PHE A CG    1 ? 
ATOM   608   C  CD1   . PHE A 1 72  ? -3.118  -14.778 -12.544  1    23.219  ? 72   PHE A CD1   1 ? 
ATOM   609   C  CD2   . PHE A 1 72  ? -3.207  -12.409 -12.857  1    25.751  ? 72   PHE A CD2   1 ? 
ATOM   610   C  CE1   . PHE A 1 72  ? -1.715  -14.721 -12.444  1    22.936  ? 72   PHE A CE1   1 ? 
ATOM   611   C  CE2   . PHE A 1 72  ? -1.826  -12.344 -12.664  1    24.211  ? 72   PHE A CE2   1 ? 
ATOM   612   C  CZ    . PHE A 1 72  ? -1.092  -13.495 -12.481  1    21.783  ? 72   PHE A CZ    1 ? 
ATOM   613   N  N     . ARG A 1 73  ? -6.243  -16.417 -14.162  1    25.324  ? 73   ARG A N     1 ? 
ATOM   614   C  CA    . ARG A 1 73  ? -5.926  -17.824 -14.348  1    28.527  ? 73   ARG A CA    1 ? 
ATOM   615   C  C     . ARG A 1 73  ? -5.893  -18.176 -15.835  1    31.076  ? 73   ARG A C     1 ? 
ATOM   616   O  O     . ARG A 1 73  ? -4.985  -18.868 -16.309  1    30.279  ? 73   ARG A O     1 ? 
ATOM   617   C  CB    . ARG A 1 73  ? -6.919  -18.715 -13.604  1    31.315  ? 73   ARG A CB    1 ? 
ATOM   618   C  CG    . ARG A 1 73  ? -6.692  -20.208 -13.802  1    31.24   ? 73   ARG A CG    1 ? 
ATOM   619   C  CD    . ARG A 1 73  ? -7.836  -20.913 -13.131  1    39.901  ? 73   ARG A CD    1 ? 
ATOM   620   N  NE    . ARG A 1 73  ? -8.974  -20.942 -14.057  1    44.634  ? 73   ARG A NE    1 ? 
ATOM   621   C  CZ    . ARG A 1 73  ? -10.217 -20.627 -13.714  1    47.036  ? 73   ARG A CZ    1 ? 
ATOM   622   N  NH1   . ARG A 1 73  ? -10.478 -20.133 -12.501  1    50.906  ? 73   ARG A NH1   1 ? 
ATOM   623   N  NH2   . ARG A 1 73  ? -11.179 -20.831 -14.601  1    41.885  ? 73   ARG A NH2   1 ? 
ATOM   624   N  N     . ILE A 1 74  ? -6.86   -17.64  -16.582  1    27.487  ? 74   ILE A N     1 ? 
ATOM   625   C  CA    . ILE A 1 74  ? -7.025  -18.017 -17.972  1    27.762  ? 74   ILE A CA    1 ? 
ATOM   626   C  C     . ILE A 1 74  ? -5.973  -17.349 -18.846  1    32.169  ? 74   ILE A C     1 ? 
ATOM   627   O  O     . ILE A 1 74  ? -5.571  -17.928 -19.851  1    30.949  ? 74   ILE A O     1 ? 
ATOM   628   C  CB    . ILE A 1 74  ? -8.426  -17.627 -18.456  1    30.518  ? 74   ILE A CB    1 ? 
ATOM   629   C  CG1   . ILE A 1 74  ? -9.461  -18.562 -17.867  1    33.399  ? 74   ILE A CG1   1 ? 
ATOM   630   C  CG2   . ILE A 1 74  ? -8.488  -17.605 -19.984  1    34.023  ? 74   ILE A CG2   1 ? 
ATOM   631   C  CD1   . ILE A 1 74  ? -10.878 -18.084 -18.102  1    36.455  ? 74   ILE A CD1   1 ? 
ATOM   632   N  N     . ILE A 1 75  ? -5.619  -16.094 -18.551  1    30.988  ? 75   ILE A N     1 ? 
ATOM   633   C  CA    . ILE A 1 75  ? -4.716  -15.382 -19.436  1    29.507  ? 75   ILE A CA    1 ? 
ATOM   634   C  C     . ILE A 1 75  ? -3.263  -15.65  -19.012  1    28.234  ? 75   ILE A C     1 ? 
ATOM   635   O  O     . ILE A 1 75  ? -2.387  -15.656 -19.858  1    30.498  ? 75   ILE A O     1 ? 
ATOM   636   C  CB    . ILE A 1 75  ? -5.065  -13.879 -19.475  1    31.798  ? 75   ILE A CB    1 ? 
ATOM   637   C  CG1   . ILE A 1 75  ? -6.472  -13.622 -20.017  1    33.783  ? 75   ILE A CG1   1 ? 
ATOM   638   C  CG2   . ILE A 1 75  ? -4.037  -13.069 -20.253  1    26.071  ? 75   ILE A CG2   1 ? 
ATOM   639   C  CD1   . ILE A 1 75  ? -6.99   -12.223 -19.729  1    37.311  ? 75   ILE A CD1   1 ? 
ATOM   640   N  N     . LYS A 1 76  ? -3      -15.8   -17.706  1    25.64   ? 76   LYS A N     1 ? 
ATOM   641   C  CA    . LYS A 1 76  ? -1.697  -16.187 -17.157  1    27.6    ? 76   LYS A CA    1 ? 
ATOM   642   C  C     . LYS A 1 76  ? -0.55   -15.345 -17.725  1    28.216  ? 76   LYS A C     1 ? 
ATOM   643   O  O     . LYS A 1 76  ? 0.42    -15.884 -18.263  1    30.825  ? 76   LYS A O     1 ? 
ATOM   644   C  CB    . LYS A 1 76  ? -1.413  -17.702 -17.199  1    36.122  ? 76   LYS A CB    1 ? 
ATOM   645   C  CG    . LYS A 1 76  ? -1.95   -18.412 -18.437  1    42.29   ? 76   LYS A CG    1 ? 
ATOM   646   C  CD    . LYS A 1 76  ? -2.053  -19.936 -18.451  1    49.473  ? 76   LYS A CD    1 ? 
ATOM   647   C  CE    . LYS A 1 76  ? -2.433  -20.353 -19.852  1    52.053  ? 76   LYS A CE    1 ? 
ATOM   648   N  NZ    . LYS A 1 76  ? -2.591  -21.803 -20.009  1    58.891  ? 76   LYS A NZ    1 ? 
ATOM   649   N  N     . PRO A 1 77  ? -0.543  -14.015 -17.483  1    28.619  ? 77   PRO A N     1 ? 
ATOM   650   C  CA    . PRO A 1 77  ? 0.527   -13.153 -17.976  1    27.887  ? 77   PRO A CA    1 ? 
ATOM   651   C  C     . PRO A 1 77  ? 1.819   -13.68  -17.357  1    27.476  ? 77   PRO A C     1 ? 
ATOM   652   O  O     . PRO A 1 77  ? 1.821   -14.035 -16.185  1    26.665  ? 77   PRO A O     1 ? 
ATOM   653   C  CB    . PRO A 1 77  ? 0.127   -11.782 -17.417  1    23.745  ? 77   PRO A CB    1 ? 
ATOM   654   C  CG    . PRO A 1 77  ? -0.695  -12.096 -16.198  1    26.903  ? 77   PRO A CG    1 ? 
ATOM   655   C  CD    . PRO A 1 77  ? -1.539  -13.279 -16.678  1    26.611  ? 77   PRO A CD    1 ? 
ATOM   656   N  N     . ARG A 1 78  ? 2.904   -13.698 -18.137  1    26.031  ? 78   ARG A N     1 ? 
ATOM   657   C  CA    . ARG A 1 78  ? 4.158   -14.297 -17.701  1    27.719  ? 78   ARG A CA    1 ? 
ATOM   658   C  C     . ARG A 1 78  ? 5.01    -13.3   -16.93   1    27.155  ? 78   ARG A C     1 ? 
ATOM   659   O  O     . ARG A 1 78  ? 5.753   -13.726 -16.054  1    28.565  ? 78   ARG A O     1 ? 
ATOM   660   C  CB    . ARG A 1 78  ? 4.966   -14.832 -18.89   1    31.922  ? 78   ARG A CB    1 ? 
ATOM   661   C  CG    . ARG A 1 78  ? 4.235   -16.026 -19.504  1    36.776  ? 78   ARG A CG    1 ? 
ATOM   662   C  CD    . ARG A 1 78  ? 4.759   -16.387 -20.895  1    45.175  ? 78   ARG A CD    1 ? 
ATOM   663   N  NE    . ARG A 1 78  ? 6.017   -17.149 -20.884  1    58.722  ? 78   ARG A NE    1 ? 
ATOM   664   C  CZ    . ARG A 1 78  ? 6.084   -18.477 -20.798  1    65.098  ? 78   ARG A CZ    1 ? 
ATOM   665   N  NH1   . ARG A 1 78  ? 4.975   -19.196 -20.785  1    61.864  ? 78   ARG A NH1   1 ? 
ATOM   666   N  NH2   . ARG A 1 78  ? 7.257   -19.086 -20.75   1    69.681  ? 78   ARG A NH2   1 ? 
ATOM   667   N  N     . LYS A 1 79  ? 4.86    -11.994 -17.214  1    23.425  ? 79   LYS A N     1 ? 
ATOM   668   C  CA    . LYS A 1 79  ? 5.763   -10.977 -16.677  1    25.996  ? 79   LYS A CA    1 ? 
ATOM   669   C  C     . LYS A 1 79  ? 5.043   -9.927  -15.826  1    26.807  ? 79   LYS A C     1 ? 
ATOM   670   O  O     . LYS A 1 79  ? 5.513   -9.624  -14.731  1    24.442  ? 79   LYS A O     1 ? 
ATOM   671   C  CB    . LYS A 1 79  ? 6.52    -10.229 -17.778  1    27.421  ? 79   LYS A CB    1 ? 
ATOM   672   C  CG    . LYS A 1 79  ? 7.372   -11.053 -18.789  1    36.338  ? 79   LYS A CG    1 ? 
ATOM   673   C  CD    . LYS A 1 79  ? 8.719   -11.512 -18.248  1    48.704  ? 79   LYS A CD    1 ? 
ATOM   674   C  CE    . LYS A 1 79  ? 9.517   -12.253 -19.269  1    59.96   ? 79   LYS A CE    1 ? 
ATOM   675   N  NZ    . LYS A 1 79  ? 9.696   -11.463 -20.499  1    58.239  ? 79   LYS A NZ    1 ? 
ATOM   676   N  N     . VAL A 1 80  ? 3.939   -9.339  -16.343  1    20.173  ? 80   VAL A N     1 ? 
ATOM   677   C  CA    . VAL A 1 80  ? 3.341   -8.17   -15.713  1    21.662  ? 80   VAL A CA    1 ? 
ATOM   678   C  C     . VAL A 1 80  ? 1.805   -8.315  -15.686  1    21.552  ? 80   VAL A C     1 ? 
ATOM   679   O  O     . VAL A 1 80  ? 1.221   -8.669  -16.692  1    21.414  ? 80   VAL A O     1 ? 
ATOM   680   C  CB    . VAL A 1 80  ? 3.765   -6.926  -16.504  1    21.014  ? 80   VAL A CB    1 ? 
ATOM   681   C  CG1   . VAL A 1 80  ? 2.904   -5.712  -16.141  1    23.299  ? 80   VAL A CG1   1 ? 
ATOM   682   C  CG2   . VAL A 1 80  ? 5.255   -6.569  -16.367  1    22.398  ? 80   VAL A CG2   1 ? 
ATOM   683   N  N     . PHE A 1 81  ? 1.149   -7.995  -14.563  1    21.46   ? 81   PHE A N     1 ? 
ATOM   684   C  CA    . PHE A 1 81  ? -0.29   -7.738  -14.552  1    21.718  ? 81   PHE A CA    1 ? 
ATOM   685   C  C     . PHE A 1 81  ? -0.553  -6.331  -14.008  1    21.999  ? 81   PHE A C     1 ? 
ATOM   686   O  O     . PHE A 1 81  ? -0.159  -6.056  -12.868  1    19.077  ? 81   PHE A O     1 ? 
ATOM   687   C  CB    . PHE A 1 81  ? -0.944  -8.761  -13.627  1    20.307  ? 81   PHE A CB    1 ? 
ATOM   688   C  CG    . PHE A 1 81  ? -2.45   -8.619  -13.46   1    23.458  ? 81   PHE A CG    1 ? 
ATOM   689   C  CD1   . PHE A 1 81  ? -3.285  -8.312  -14.53   1    24.694  ? 81   PHE A CD1   1 ? 
ATOM   690   C  CD2   . PHE A 1 81  ? -3.04   -8.788  -12.206  1    29.15   ? 81   PHE A CD2   1 ? 
ATOM   691   C  CE1   . PHE A 1 81  ? -4.669  -8.162  -14.357  1    30.071  ? 81   PHE A CE1   1 ? 
ATOM   692   C  CE2   . PHE A 1 81  ? -4.424  -8.657  -12.041  1    31.207  ? 81   PHE A CE2   1 ? 
ATOM   693   C  CZ    . PHE A 1 81  ? -5.247  -8.364  -13.114  1    27.306  ? 81   PHE A CZ    1 ? 
ATOM   694   N  N     . PHE A 1 82  ? -1.163  -5.452  -14.826  1    19.684  ? 82   PHE A N     1 ? 
ATOM   695   C  CA    . PHE A 1 82  ? -1.444  -4.083  -14.389  1    19.925  ? 82   PHE A CA    1 ? 
ATOM   696   C  C     . PHE A 1 82  ? -2.972  -3.934  -14.246  1    23.917  ? 82   PHE A C     1 ? 
ATOM   697   O  O     . PHE A 1 82  ? -3.696  -3.997  -15.264  1    23.88   ? 82   PHE A O     1 ? 
ATOM   698   C  CB    . PHE A 1 82  ? -0.896  -3.106  -15.434  1    18.403  ? 82   PHE A CB    1 ? 
ATOM   699   C  CG    . PHE A 1 82  ? -0.845  -1.65   -15.004  1    20.606  ? 82   PHE A CG    1 ? 
ATOM   700   C  CD1   . PHE A 1 82  ? -2.02   -0.894  -14.87   1    19.841  ? 82   PHE A CD1   1 ? 
ATOM   701   C  CD2   . PHE A 1 82  ? 0.376   -1.031  -14.759  1    18.09   ? 82   PHE A CD2   1 ? 
ATOM   702   C  CE1   . PHE A 1 82  ? -1.956  0.423   -14.446  1    21.022  ? 82   PHE A CE1   1 ? 
ATOM   703   C  CE2   . PHE A 1 82  ? 0.436   0.285   -14.361  1    18.649  ? 82   PHE A CE2   1 ? 
ATOM   704   C  CZ    . PHE A 1 82  ? -0.722  1.009   -14.174  1    20.099  ? 82   PHE A CZ    1 ? 
ATOM   705   N  N     . MET A 1 83  ? -3.448  -3.769  -12.991  1    19.775  ? 83   MET A N     1 ? 
ATOM   706   C  CA    A MET A 1 83  ? -4.865  -3.537  -12.729  0.5  20.384  ? 83   MET A CA    1 ? 
ATOM   707   C  CA    B MET A 1 83  ? -4.861  -3.546  -12.681  0.5  20.115  ? 83   MET A CA    1 ? 
ATOM   708   C  C     . MET A 1 83  ? -5.101  -2.068  -12.369  1    19.384  ? 83   MET A C     1 ? 
ATOM   709   O  O     . MET A 1 83  ? -4.386  -1.496  -11.538  1    17.115  ? 83   MET A O     1 ? 
ATOM   710   C  CB    A MET A 1 83  ? -5.51   -4.587  -11.8    0.5  21      ? 83   MET A CB    1 ? 
ATOM   711   C  CB    B MET A 1 83  ? -5.314  -4.409  -11.495  0.5  20.64   ? 83   MET A CB    1 ? 
ATOM   712   C  CG    A MET A 1 83  ? -4.7    -5.036  -10.595  0.5  27.267  ? 83   MET A CG    1 ? 
ATOM   713   C  CG    B MET A 1 83  ? -6.781  -4.249  -11.08   0.5  23.912  ? 83   MET A CG    1 ? 
ATOM   714   S  SD    A MET A 1 83  ? -5.427  -6.373  -9.607   0.5  26.075  ? 83   MET A SD    1 ? 
ATOM   715   S  SD    B MET A 1 83  ? -7.258  -5.516  -9.883   0.5  26.396  ? 83   MET A SD    1 ? 
ATOM   716   C  CE    A MET A 1 83  ? -6.34   -5.365  -8.439   0.5  22.224  ? 83   MET A CE    1 ? 
ATOM   717   C  CE    B MET A 1 83  ? -5.995  -6.541  -10.64   0.5  21.921  ? 83   MET A CE    1 ? 
ATOM   718   N  N     . ALA A 1 84  ? -6.089  -1.436  -13.054  1    15.131  ? 84   ALA A N     1 ? 
ATOM   719   C  CA    . ALA A 1 84  ? -6.372  -0.033  -12.776  1    15.848  ? 84   ALA A CA    1 ? 
ATOM   720   C  C     . ALA A 1 84  ? -7.866  0.15    -12.475  1    17.288  ? 84   ALA A C     1 ? 
ATOM   721   O  O     . ALA A 1 84  ? -8.672  -0.514  -13.115  1    18.867  ? 84   ALA A O     1 ? 
ATOM   722   C  CB    . ALA A 1 84  ? -5.989  0.819   -13.969  1    15.165  ? 84   ALA A CB    1 ? 
ATOM   723   N  N     . VAL A 1 85  ? -8.212  0.997   -11.492  1    16.147  ? 85   VAL A N     1 ? 
ATOM   724   C  CA    . VAL A 1 85  ? -9.561  1.535   -11.306  1    14.345  ? 85   VAL A CA    1 ? 
ATOM   725   C  C     . VAL A 1 85  ? -9.45   2.986   -11.748  1    17.023  ? 85   VAL A C     1 ? 
ATOM   726   O  O     . VAL A 1 85  ? -8.39   3.607   -11.527  1    16.423  ? 85   VAL A O     1 ? 
ATOM   727   C  CB    . VAL A 1 85  ? -9.912  1.411   -9.804   1    12.573  ? 85   VAL A CB    1 ? 
ATOM   728   C  CG1   . VAL A 1 85  ? -11.233 2.087   -9.421   1    10.677  ? 85   VAL A CG1   1 ? 
ATOM   729   C  CG2   . VAL A 1 85  ? -10.005 -0.076  -9.413   1    11.835  ? 85   VAL A CG2   1 ? 
ATOM   730   N  N     . ASP A 1 86  ? -10.495 3.541   -12.372  1    15.889  ? 86   ASP A N     1 ? 
ATOM   731   C  CA    . ASP A 1 86  ? -10.485 4.948   -12.775  1    17.595  ? 86   ASP A CA    1 ? 
ATOM   732   C  C     . ASP A 1 86  ? -10.228 5.829   -11.555  1    16.661  ? 86   ASP A C     1 ? 
ATOM   733   O  O     . ASP A 1 86  ? -10.943 5.721   -10.57   1    15.901  ? 86   ASP A O     1 ? 
ATOM   734   C  CB    . ASP A 1 86  ? -11.736 5.363   -13.561  1    21.012  ? 86   ASP A CB    1 ? 
ATOM   735   C  CG    . ASP A 1 86  ? -11.865 4.775   -14.971  1    26.812  ? 86   ASP A CG    1 ? 
ATOM   736   O  OD1   . ASP A 1 86  ? -10.999 3.971   -15.317  1    29.937  ? 86   ASP A OD1   1 ? 
ATOM   737   O  OD2   . ASP A 1 86  ? -12.728 5.209   -15.814  1    33.844  ? 86   ASP A OD2   1 ? 
ATOM   738   N  N     . GLY A 1 87  ? -9.249  6.763   -11.643  1    16.338  ? 87   GLY A N     1 ? 
ATOM   739   C  CA    . GLY A 1 87  ? -9.122  7.856   -10.69   1    15.028  ? 87   GLY A CA    1 ? 
ATOM   740   C  C     . GLY A 1 87  ? -9.832  9.103   -11.227  1    16.085  ? 87   GLY A C     1 ? 
ATOM   741   O  O     . GLY A 1 87  ? -10.488 9.002   -12.249  1    17.025  ? 87   GLY A O     1 ? 
ATOM   742   N  N     . VAL A 1 88  ? -9.661  10.286  -10.61   1    17.083  ? 88   VAL A N     1 ? 
ATOM   743   C  CA    . VAL A 1 88  ? -10.268 11.5    -11.136  1    17.056  ? 88   VAL A CA    1 ? 
ATOM   744   C  C     . VAL A 1 88  ? -9.858  11.687  -12.602  1    19.94   ? 88   VAL A C     1 ? 
ATOM   745   O  O     . VAL A 1 88  ? -8.698  11.495  -12.999  1    16.215  ? 88   VAL A O     1 ? 
ATOM   746   C  CB    . VAL A 1 88  ? -10.021 12.785  -10.323  1    18.308  ? 88   VAL A CB    1 ? 
ATOM   747   C  CG1   . VAL A 1 88  ? -10.391 12.628  -8.839   1    17.293  ? 88   VAL A CG1   1 ? 
ATOM   748   C  CG2   . VAL A 1 88  ? -8.574  13.186  -10.397  1    22.969  ? 88   VAL A CG2   1 ? 
ATOM   749   N  N     . ALA A 1 89  ? -10.828 12.099  -13.411  1    15.889  ? 89   ALA A N     1 ? 
ATOM   750   C  CA    . ALA A 1 89  ? -10.622 12.268  -14.833  1    16.011  ? 89   ALA A CA    1 ? 
ATOM   751   C  C     . ALA A 1 89  ? -10.342 13.736  -15.141  1    15.123  ? 89   ALA A C     1 ? 
ATOM   752   O  O     . ALA A 1 89  ? -10.592 14.635  -14.338  1    17.095  ? 89   ALA A O     1 ? 
ATOM   753   C  CB    . ALA A 1 89  ? -11.824 11.777  -15.593  1    14.527  ? 89   ALA A CB    1 ? 
ATOM   754   N  N     . PRO A 1 90  ? -9.739  14.019  -16.308  1    15.572  ? 90   PRO A N     1 ? 
ATOM   755   C  CA    . PRO A 1 90  ? -9.633  15.385  -16.82   1    16.167  ? 90   PRO A CA    1 ? 
ATOM   756   C  C     . PRO A 1 90  ? -11.064 15.919  -16.903  1    18.665  ? 90   PRO A C     1 ? 
ATOM   757   O  O     . PRO A 1 90  ? -11.989 15.147  -17.173  1    18.822  ? 90   PRO A O     1 ? 
ATOM   758   C  CB    . PRO A 1 90  ? -9.094  15.213  -18.257  1    16.117  ? 90   PRO A CB    1 ? 
ATOM   759   C  CG    . PRO A 1 90  ? -8.535  13.823  -18.315  1    21.009  ? 90   PRO A CG    1 ? 
ATOM   760   C  CD    . PRO A 1 90  ? -9.159  13.005  -17.193  1    19.367  ? 90   PRO A CD    1 ? 
ATOM   761   N  N     . ARG A 1 91  ? -11.206 17.235  -16.818  1    18.036  ? 91   ARG A N     1 ? 
ATOM   762   C  CA    . ARG A 1 91  ? -12.499 17.918  -16.906  1    19.093  ? 91   ARG A CA    1 ? 
ATOM   763   C  C     . ARG A 1 91  ? -13.103 17.761  -18.295  1    20.727  ? 91   ARG A C     1 ? 
ATOM   764   O  O     . ARG A 1 91  ? -14.321 17.867  -18.487  1    22.601  ? 91   ARG A O     1 ? 
ATOM   765   C  CB    . ARG A 1 91  ? -12.369 19.386  -16.459  1    19.008  ? 91   ARG A CB    1 ? 
ATOM   766   C  CG    . ARG A 1 91  ? -12.645 19.582  -14.971  1    20.634  ? 91   ARG A CG    1 ? 
ATOM   767   C  CD    . ARG A 1 91  ? -11.445 19.175  -14.113  1    22.67   ? 91   ARG A CD    1 ? 
ATOM   768   N  NE    . ARG A 1 91  ? -10.564 20.346  -13.981  1    22.198  ? 91   ARG A NE    1 ? 
ATOM   769   C  CZ    . ARG A 1 91  ? -9.315  20.345  -13.507  1    22.415  ? 91   ARG A CZ    1 ? 
ATOM   770   N  NH1   . ARG A 1 91  ? -8.766  19.197  -13.092  1    23.003  ? 91   ARG A NH1   1 ? 
ATOM   771   N  NH2   . ARG A 1 91  ? -8.617  21.477  -13.521  1    17.052  ? 91   ARG A NH2   1 ? 
ATOM   772   N  N     . ALA A 1 92  ? -12.262 17.386  -19.255  1    19.503  ? 92   ALA A N     1 ? 
ATOM   773   C  CA    . ALA A 1 92  ? -12.768 17.049  -20.571  1    20.297  ? 92   ALA A CA    1 ? 
ATOM   774   C  C     . ALA A 1 92  ? -13.852 15.98   -20.493  1    21.822  ? 92   ALA A C     1 ? 
ATOM   775   O  O     . ALA A 1 92  ? -14.634 15.847  -21.441  1    19.233  ? 92   ALA A O     1 ? 
ATOM   776   C  CB    . ALA A 1 92  ? -11.654 16.592  -21.489  1    17.477  ? 92   ALA A CB    1 ? 
ATOM   777   N  N     . LYS A 1 93  ? -13.844 15.177  -19.423  1    19.665  ? 93   LYS A N     1 ? 
ATOM   778   C  CA    . LYS A 1 93  ? -14.793 14.076  -19.333  1    20.551  ? 93   LYS A CA    1 ? 
ATOM   779   C  C     . LYS A 1 93  ? -16.001 14.474  -18.47   1    21.908  ? 93   LYS A C     1 ? 
ATOM   780   O  O     . LYS A 1 93  ? -16.915 13.678  -18.326  1    22.559  ? 93   LYS A O     1 ? 
ATOM   781   C  CB    . LYS A 1 93  ? -14.165 12.901  -18.561  1    20.718  ? 93   LYS A CB    1 ? 
ATOM   782   C  CG    . LYS A 1 93  ? -14.506 11.555  -19.199  1    28.718  ? 93   LYS A CG    1 ? 
ATOM   783   C  CD    . LYS A 1 93  ? -14.21  10.257  -18.438  1    31.176  ? 93   LYS A CD    1 ? 
ATOM   784   C  CE    . LYS A 1 93  ? -15.015 9.136   -19.072  1    27.366  ? 93   LYS A CE    1 ? 
ATOM   785   N  NZ    . LYS A 1 93  ? -14.827 7.858   -18.382  1    32.684  ? 93   LYS A NZ    1 ? 
ATOM   786   N  N     . MET A 1 94  ? -15.956 15.649  -17.828  1    18.02   ? 94   MET A N     1 ? 
ATOM   787   C  CA    . MET A 1 94  ? -16.874 16.006  -16.74   1    19.018  ? 94   MET A CA    1 ? 
ATOM   788   C  C     . MET A 1 94  ? -18.332 15.971  -17.199  1    21.475  ? 94   MET A C     1 ? 
ATOM   789   O  O     . MET A 1 94  ? -19.206 15.457  -16.482  1    22.165  ? 94   MET A O     1 ? 
ATOM   790   C  CB    . MET A 1 94  ? -16.504 17.384  -16.181  1    18.878  ? 94   MET A CB    1 ? 
ATOM   791   C  CG    . MET A 1 94  ? -17.445 17.908  -15.065  1    21.536  ? 94   MET A CG    1 ? 
ATOM   792   S  SD    . MET A 1 94  ? -16.672 19.209  -14.084  1    28.308  ? 94   MET A SD    1 ? 
ATOM   793   C  CE    . MET A 1 94  ? -16.092 20.312  -15.4    1    27.089  ? 94   MET A CE    1 ? 
ATOM   794   N  N     . ASN A 1 95  ? -18.574 16.482  -18.417  1    18.319  ? 95   ASN A N     1 ? 
ATOM   795   C  CA    . ASN A 1 95  ? -19.927 16.596  -18.933  1    20.917  ? 95   ASN A CA    1 ? 
ATOM   796   C  C     . ASN A 1 95  ? -20.476 15.186  -19.132  1    22.784  ? 95   ASN A C     1 ? 
ATOM   797   O  O     . ASN A 1 95  ? -21.603 14.879  -18.738  1    21.941  ? 95   ASN A O     1 ? 
ATOM   798   C  CB    . ASN A 1 95  ? -20.003 17.439  -20.216  1    20.95   ? 95   ASN A CB    1 ? 
ATOM   799   C  CG    . ASN A 1 95  ? -21.376 17.274  -20.853  1    20.893  ? 95   ASN A CG    1 ? 
ATOM   800   O  OD1   . ASN A 1 95  ? -22.389 17.606  -20.241  1    19.398  ? 95   ASN A OD1   1 ? 
ATOM   801   N  ND2   . ASN A 1 95  ? -21.446 16.671  -22.022  1    21.11   ? 95   ASN A ND2   1 ? 
ATOM   802   N  N     . GLN A 1 96  ? -19.674 14.301  -19.729  1    22.541  ? 96   GLN A N     1 ? 
ATOM   803   C  CA    . GLN A 1 96  ? -20.214 12.973  -19.977  1    25.141  ? 96   GLN A CA    1 ? 
ATOM   804   C  C     . GLN A 1 96  ? -20.368 12.178  -18.68   1    23.967  ? 96   GLN A C     1 ? 
ATOM   805   O  O     . GLN A 1 96  ? -21.276 11.343  -18.565  1    18.809  ? 96   GLN A O     1 ? 
ATOM   806   C  CB    . GLN A 1 96  ? -19.638 12.258  -21.203  1    33.276  ? 96   GLN A CB    1 ? 
ATOM   807   C  CG    . GLN A 1 96  ? -18.277 11.637  -20.985  1    48.255  ? 96   GLN A CG    1 ? 
ATOM   808   C  CD    . GLN A 1 96  ? -18.359 10.157  -20.688  1    64.22   ? 96   GLN A CD    1 ? 
ATOM   809   O  OE1   . GLN A 1 96  ? -17.335 9.469   -20.604  1    71.573  ? 96   GLN A OE1   1 ? 
ATOM   810   N  NE2   . GLN A 1 96  ? -19.574 9.646   -20.546  1    61.744  ? 96   GLN A NE2   1 ? 
ATOM   811   N  N     . GLN A 1 97  ? -19.475 12.413  -17.712  1    18.036  ? 97   GLN A N     1 ? 
ATOM   812   C  CA    . GLN A 1 97  ? -19.631 11.752  -16.424  1    17.657  ? 97   GLN A CA    1 ? 
ATOM   813   C  C     . GLN A 1 97  ? -20.916 12.202  -15.708  1    16.052  ? 97   GLN A C     1 ? 
ATOM   814   O  O     . GLN A 1 97  ? -21.619 11.374  -15.099  1    16.95   ? 97   GLN A O     1 ? 
ATOM   815   C  CB    . GLN A 1 97  ? -18.417 12.055  -15.547  1    16.337  ? 97   GLN A CB    1 ? 
ATOM   816   C  CG    . GLN A 1 97  ? -17.187 11.247  -15.981  1    16.832  ? 97   GLN A CG    1 ? 
ATOM   817   C  CD    . GLN A 1 97  ? -15.983 11.6    -15.125  1    20.795  ? 97   GLN A CD    1 ? 
ATOM   818   O  OE1   . GLN A 1 97  ? -15.741 12.77   -14.838  1    21.999  ? 97   GLN A OE1   1 ? 
ATOM   819   N  NE2   . GLN A 1 97  ? -15.273 10.596  -14.653  1    20.215  ? 97   GLN A NE2   1 ? 
ATOM   820   N  N     . ARG A 1 98  ? -21.214 13.499  -15.795  1    13.837  ? 98   ARG A N     1 ? 
ATOM   821   C  CA    . ARG A 1 98  ? -22.43  14.092  -15.236  1    16.448  ? 98   ARG A CA    1 ? 
ATOM   822   C  C     . ARG A 1 98  ? -23.655 13.498  -15.922  1    17.532  ? 98   ARG A C     1 ? 
ATOM   823   O  O     . ARG A 1 98  ? -24.545 12.988  -15.25   1    21.433  ? 98   ARG A O     1 ? 
ATOM   824   C  CB    . ARG A 1 98  ? -22.479 15.611  -15.379  1    16.05   ? 98   ARG A CB    1 ? 
ATOM   825   C  CG    . ARG A 1 98  ? -21.622 16.262  -14.309  1    16.097  ? 98   ARG A CG    1 ? 
ATOM   826   C  CD    . ARG A 1 98  ? -21.311 17.707  -14.652  1    16.232  ? 98   ARG A CD    1 ? 
ATOM   827   N  NE    . ARG A 1 98  ? -22.47  18.553  -14.962  1    17.667  ? 98   ARG A NE    1 ? 
ATOM   828   C  CZ    . ARG A 1 98  ? -23.355 19.066  -14.093  1    16.524  ? 98   ARG A CZ    1 ? 
ATOM   829   N  NH1   . ARG A 1 98  ? -23.308 18.774  -12.798  1    18.614  ? 98   ARG A NH1   1 ? 
ATOM   830   N  NH2   . ARG A 1 98  ? -24.318 19.846  -14.533  1    16.935  ? 98   ARG A NH2   1 ? 
ATOM   831   N  N     . GLY A 1 99  ? -23.62  13.483  -17.258  1    17.16   ? 99   GLY A N     1 ? 
ATOM   832   C  CA    . GLY A 1 99  ? -24.663 12.937  -18.111  1    18.418  ? 99   GLY A CA    1 ? 
ATOM   833   C  C     . GLY A 1 99  ? -25.044 11.537  -17.666  1    21.761  ? 99   GLY A C     1 ? 
ATOM   834   O  O     . GLY A 1 99  ? -26.226 11.254  -17.469  1    19.206  ? 99   GLY A O     1 ? 
ATOM   835   N  N     . ARG A 1 100 ? -24.053 10.639  -17.532  1    20.462  ? 100  ARG A N     1 ? 
ATOM   836   C  CA    . ARG A 1 100 ? -24.358 9.284   -17.099  1    21.033  ? 100  ARG A CA    1 ? 
ATOM   837   C  C     . ARG A 1 100 ? -24.951 9.213   -15.683  1    19.92   ? 100  ARG A C     1 ? 
ATOM   838   O  O     . ARG A 1 100 ? -25.881 8.432   -15.402  1    17.476  ? 100  ARG A O     1 ? 
ATOM   839   C  CB    . ARG A 1 100 ? -23.074 8.464   -17.034  1    26.942  ? 100  ARG A CB    1 ? 
ATOM   840   C  CG    . ARG A 1 100 ? -22.89  7.811   -18.387  1    39.861  ? 100  ARG A CG    1 ? 
ATOM   841   C  CD    . ARG A 1 100 ? -21.653 6.934   -18.405  1    55.351  ? 100  ARG A CD    1 ? 
ATOM   842   N  NE    . ARG A 1 100 ? -20.469 7.797   -18.512  1    54.011  ? 100  ARG A NE    1 ? 
ATOM   843   C  CZ    . ARG A 1 100 ? -19.195 7.445   -18.669  1    52.876  ? 100  ARG A CZ    1 ? 
ATOM   844   N  NH1   . ARG A 1 100 ? -18.839 6.189   -18.863  1    46.969  ? 100  ARG A NH1   1 ? 
ATOM   845   N  NH2   . ARG A 1 100 ? -18.268 8.385   -18.625  1    55.648  ? 100  ARG A NH2   1 ? 
ATOM   846   N  N     . ARG A 1 101 ? -24.415 10.004  -14.758  1    17.528  ? 101  ARG A N     1 ? 
ATOM   847   C  CA    . ARG A 1 101 ? -24.859 9.877   -13.375  1    15.604  ? 101  ARG A CA    1 ? 
ATOM   848   C  C     . ARG A 1 101 ? -26.277 10.475  -13.21   1    17.152  ? 101  ARG A C     1 ? 
ATOM   849   O  O     . ARG A 1 101 ? -27.084 9.955   -12.464  1    17.106  ? 101  ARG A O     1 ? 
ATOM   850   C  CB    . ARG A 1 101 ? -23.778 10.479  -12.483  1    14.258  ? 101  ARG A CB    1 ? 
ATOM   851   C  CG    . ARG A 1 101 ? -22.564 9.551   -12.386  1    15.405  ? 101  ARG A CG    1 ? 
ATOM   852   C  CD    . ARG A 1 101 ? -21.333 10.339  -11.903  1    16.52   ? 101  ARG A CD    1 ? 
ATOM   853   N  NE    . ARG A 1 101 ? -20.212 9.435   -11.642  1    15.585  ? 101  ARG A NE    1 ? 
ATOM   854   C  CZ    . ARG A 1 101 ? -19.474 8.863   -12.581  1    15.695  ? 101  ARG A CZ    1 ? 
ATOM   855   N  NH1   . ARG A 1 101 ? -19.715 9.098   -13.873  1    12.98   ? 101  ARG A NH1   1 ? 
ATOM   856   N  NH2   . ARG A 1 101 ? -18.55  7.973   -12.2    1    15.17   ? 101  ARG A NH2   1 ? 
ATOM   857   N  N     . PHE A 1 102 ? -26.544 11.617  -13.835  1    17.327  ? 102  PHE A N     1 ? 
ATOM   858   C  CA    . PHE A 1 102 ? -27.877 12.218  -13.839  1    19.068  ? 102  PHE A CA    1 ? 
ATOM   859   C  C     . PHE A 1 102 ? -28.887 11.238  -14.446  1    20.885  ? 102  PHE A C     1 ? 
ATOM   860   O  O     . PHE A 1 102 ? -29.93  11.02   -13.859  1    19.135  ? 102  PHE A O     1 ? 
ATOM   861   C  CB    . PHE A 1 102 ? -27.835 13.549  -14.606  1    16.911  ? 102  PHE A CB    1 ? 
ATOM   862   C  CG    . PHE A 1 102 ? -27.383 14.74   -13.768  1    18.222  ? 102  PHE A CG    1 ? 
ATOM   863   C  CD1   . PHE A 1 102 ? -26.098 14.793  -13.238  1    14.972  ? 102  PHE A CD1   1 ? 
ATOM   864   C  CD2   . PHE A 1 102 ? -28.257 15.807  -13.516  1    19.035  ? 102  PHE A CD2   1 ? 
ATOM   865   C  CE1   . PHE A 1 102 ? -25.686 15.888  -12.506  1    18.433  ? 102  PHE A CE1   1 ? 
ATOM   866   C  CE2   . PHE A 1 102 ? -27.852 16.891  -12.761  1    21      ? 102  PHE A CE2   1 ? 
ATOM   867   C  CZ    . PHE A 1 102 ? -26.56  16.923  -12.244  1    22.492  ? 102  PHE A CZ    1 ? 
ATOM   868   N  N     . ARG A 1 103 ? -28.606 10.65   -15.616  1    19.502  ? 103  ARG A N     1 ? 
ATOM   869   C  CA    . ARG A 1 103 ? -29.545 9.703   -16.209  1    23.908  ? 103  ARG A CA    1 ? 
ATOM   870   C  C     . ARG A 1 103 ? -29.745 8.456   -15.342  1    23.324  ? 103  ARG A C     1 ? 
ATOM   871   O  O     . ARG A 1 103 ? -30.833 7.885   -15.223  1    20.071  ? 103  ARG A O     1 ? 
ATOM   872   C  CB    . ARG A 1 103 ? -29.023 9.15    -17.547  1    26.598  ? 103  ARG A CB    1 ? 
ATOM   873   C  CG    . ARG A 1 103 ? -29.344 9.998   -18.768  1    44.901  ? 103  ARG A CG    1 ? 
ATOM   874   C  CD    . ARG A 1 103 ? -30.856 10.243  -18.957  1    54.424  ? 103  ARG A CD    1 ? 
ATOM   875   N  NE    . ARG A 1 103 ? -31.541 9.084   -19.543  1    66.876  ? 103  ARG A NE    1 ? 
ATOM   876   C  CZ    . ARG A 1 103 ? -32.854 8.958   -19.722  1    71.443  ? 103  ARG A CZ    1 ? 
ATOM   877   N  NH1   . ARG A 1 103 ? -33.697 9.871   -19.248  1    65.993  ? 103  ARG A NH1   1 ? 
ATOM   878   N  NH2   . ARG A 1 103 ? -33.31  7.893   -20.362  1    66.74   ? 103  ARG A NH2   1 ? 
ATOM   879   N  N     . SER A 1 104 ? -28.652 7.947   -14.806  1    19.543  ? 104  SER A N     1 ? 
ATOM   880   C  CA    . SER A 1 104 ? -28.744 6.789   -13.953  1    22.801  ? 104  SER A CA    1 ? 
ATOM   881   C  C     . SER A 1 104 ? -29.746 7.002   -12.81   1    22.829  ? 104  SER A C     1 ? 
ATOM   882   O  O     . SER A 1 104 ? -30.557 6.116   -12.535  1    21.947  ? 104  SER A O     1 ? 
ATOM   883   C  CB    . SER A 1 104 ? -27.346 6.41    -13.45   1    26.719  ? 104  SER A CB    1 ? 
ATOM   884   O  OG    . SER A 1 104 ? -27.454 5.492   -12.383  1    29.849  ? 104  SER A OG    1 ? 
ATOM   885   N  N     . ALA A 1 105 ? -29.651 8.123   -12.093  1    18.953  ? 105  ALA A N     1 ? 
ATOM   886   C  CA    . ALA A 1 105 ? -30.57  8.397   -10.99   1    21.635  ? 105  ALA A CA    1 ? 
ATOM   887   C  C     . ALA A 1 105 ? -32.003 8.581   -11.521  1    20.016  ? 105  ALA A C     1 ? 
ATOM   888   O  O     . ALA A 1 105 ? -32.93  8.043   -10.954  1    20.914  ? 105  ALA A O     1 ? 
ATOM   889   C  CB    . ALA A 1 105 ? -30.159 9.635   -10.252  1    20.437  ? 105  ALA A CB    1 ? 
ATOM   890   N  N     . LYS A 1 106 ? -32.171 9.311   -12.612  1    19.831  ? 106  LYS A N     1 ? 
ATOM   891   C  CA    . LYS A 1 106 ? -33.494 9.48    -13.234  1    24.238  ? 106  LYS A CA    1 ? 
ATOM   892   C  C     . LYS A 1 106 ? -34.1   8.126   -13.624  1    23.748  ? 106  LYS A C     1 ? 
ATOM   893   O  O     . LYS A 1 106 ? -35.265 7.846   -13.317  1    22.023  ? 106  LYS A O     1 ? 
ATOM   894   C  CB    . LYS A 1 106 ? -33.376 10.426  -14.441  1    25.262  ? 106  LYS A CB    1 ? 
ATOM   895   C  CG    . LYS A 1 106 ? -34.712 10.819  -15.103  1    33.667  ? 106  LYS A CG    1 ? 
ATOM   896   C  CD    . LYS A 1 106 ? -34.642 11.63   -16.405  1    40.608  ? 106  LYS A CD    1 ? 
ATOM   897   C  CE    . LYS A 1 106 ? -36.039 11.988  -16.939  1    38.993  ? 106  LYS A CE    1 ? 
ATOM   898   N  NZ    . LYS A 1 106 ? -36.865 10.777  -17.103  1    39.028  ? 106  LYS A NZ    1 ? 
ATOM   899   N  N     . GLU A 1 107 ? -33.304 7.26    -14.276  1    22.264  ? 107  GLU A N     1 ? 
ATOM   900   C  CA    . GLU A 1 107 ? -33.834 5.998   -14.759  1    24.033  ? 107  GLU A CA    1 ? 
ATOM   901   C  C     . GLU A 1 107 ? -34.218 5.106   -13.59   1    24.669  ? 107  GLU A C     1 ? 
ATOM   902   O  O     . GLU A 1 107 ? -35.258 4.461   -13.646  1    22.325  ? 107  GLU A O     1 ? 
ATOM   903   C  CB    . GLU A 1 107 ? -32.932 5.21    -15.707  1    28.339  ? 107  GLU A CB    1 ? 
ATOM   904   C  CG    . GLU A 1 107 ? -32.64  6.018   -16.966  1    32.679  ? 107  GLU A CG    1 ? 
ATOM   905   C  CD    . GLU A 1 107 ? -31.646 5.399   -17.924  1    42.203  ? 107  GLU A CD    1 ? 
ATOM   906   O  OE1   . GLU A 1 107 ? -30.942 4.457   -17.486  1    50.485  ? 107  GLU A OE1   1 ? 
ATOM   907   O  OE2   . GLU A 1 107 ? -31.58  5.833   -19.099  1    40.338  ? 107  GLU A OE2   1 ? 
ATOM   908   N  N     . ALA A 1 108 ? -33.394 5.084   -12.538  1    21.763  ? 108  ALA A N     1 ? 
ATOM   909   C  CA    . ALA A 1 108 ? -33.691 4.293   -11.348  1    21.105  ? 108  ALA A CA    1 ? 
ATOM   910   C  C     . ALA A 1 108 ? -35.048 4.68    -10.744  1    19.95   ? 108  ALA A C     1 ? 
ATOM   911   O  O     . ALA A 1 108 ? -35.859 3.819   -10.415  1    20.847  ? 108  ALA A O     1 ? 
ATOM   912   C  CB    . ALA A 1 108 ? -32.605 4.443   -10.296  1    16.496  ? 108  ALA A CB    1 ? 
ATOM   913   N  N     . GLU A 1 109 ? -35.233 5.981   -10.521  1    21.859  ? 109  GLU A N     1 ? 
ATOM   914   C  CA    . GLU A 1 109 ? -36.465 6.555   -9.982   1    25.921  ? 109  GLU A CA    1 ? 
ATOM   915   C  C     . GLU A 1 109 ? -37.695 6.22    -10.857  1    21.311  ? 109  GLU A C     1 ? 
ATOM   916   O  O     . GLU A 1 109 ? -38.772 5.923   -10.336  1    25.121  ? 109  GLU A O     1 ? 
ATOM   917   C  CB    . GLU A 1 109 ? -36.226 8.043   -9.671   1    26.64   ? 109  GLU A CB    1 ? 
ATOM   918   C  CG    . GLU A 1 109 ? -37.493 8.783   -9.226   1    35.527  ? 109  GLU A CG    1 ? 
ATOM   919   C  CD    . GLU A 1 109 ? -38.087 8.434   -7.858   1    43.055  ? 109  GLU A CD    1 ? 
ATOM   920   O  OE1   . GLU A 1 109 ? -37.355 7.925   -6.96    1    42.22   ? 109  GLU A OE1   1 ? 
ATOM   921   O  OE2   . GLU A 1 109 ? -39.336 8.625   -7.714   1    42.981  ? 109  GLU A OE2   1 ? 
ATOM   922   N  N     . ASP A 1 110 ? -37.563 6.312   -12.174  1    23.155  ? 110  ASP A N     1 ? 
ATOM   923   C  CA    A ASP A 1 110 ? -38.654 5.935   -13.057  0.5  25.086  ? 110  ASP A CA    1 ? 
ATOM   924   C  CA    B ASP A 1 110 ? -38.598 5.916   -13.127  0.5  25.474  ? 110  ASP A CA    1 ? 
ATOM   925   C  C     . ASP A 1 110 ? -39.023 4.463   -12.877  1    26.767  ? 110  ASP A C     1 ? 
ATOM   926   O  O     . ASP A 1 110 ? -40.212 4.132   -12.805  1    25.021  ? 110  ASP A O     1 ? 
ATOM   927   C  CB    A ASP A 1 110 ? -38.377 6.242   -14.515  0.5  27      ? 110  ASP A CB    1 ? 
ATOM   928   C  CB    B ASP A 1 110 ? -38.133 6.083   -14.572  0.5  27.947  ? 110  ASP A CB    1 ? 
ATOM   929   C  CG    A ASP A 1 110 ? -39.636 6.262   -15.365  0.5  29.751  ? 110  ASP A CG    1 ? 
ATOM   930   C  CG    B ASP A 1 110 ? -37.965 7.51    -15.096  0.5  32.645  ? 110  ASP A CG    1 ? 
ATOM   931   O  OD1   A ASP A 1 110 ? -40.591 6.977   -14.975  0.5  35.041  ? 110  ASP A OD1   1 ? 
ATOM   932   O  OD1   B ASP A 1 110 ? -38.461 8.439   -14.449  0.5  35.277  ? 110  ASP A OD1   1 ? 
ATOM   933   O  OD2   A ASP A 1 110 ? -39.663 5.55    -16.379  0.5  32.817  ? 110  ASP A OD2   1 ? 
ATOM   934   O  OD2   B ASP A 1 110 ? -37.337 7.688   -16.171  0.5  36.905  ? 110  ASP A OD2   1 ? 
ATOM   935   N  N     . LYS A 1 111 ? -38.027 3.568   -12.774  1    22.946  ? 111  LYS A N     1 ? 
ATOM   936   C  CA    . LYS A 1 111 ? -38.361 2.171   -12.529  1    21.613  ? 111  LYS A CA    1 ? 
ATOM   937   C  C     . LYS A 1 111 ? -39.152 1.973   -11.234  1    22.715  ? 111  LYS A C     1 ? 
ATOM   938   O  O     . LYS A 1 111 ? -40.084 1.173   -11.228  1    23.473  ? 111  LYS A O     1 ? 
ATOM   939   C  CB    . LYS A 1 111 ? -37.143 1.265   -12.683  1    22.115  ? 111  LYS A CB    1 ? 
ATOM   940   C  CG    . LYS A 1 111 ? -36.665 1.24    -14.132  1    24.106  ? 111  LYS A CG    1 ? 
ATOM   941   C  CD    . LYS A 1 111 ? -35.53  0.217   -14.22   1    31.727  ? 111  LYS A CD    1 ? 
ATOM   942   C  CE    . LYS A 1 111 ? -34.853 0.24    -15.571  1    35.522  ? 111  LYS A CE    1 ? 
ATOM   943   N  NZ    . LYS A 1 111 ? -33.796 1.237   -15.459  1    38.078  ? 111  LYS A NZ    1 ? 
ATOM   944   N  N     . ILE A 1 112 ? -38.735 2.641   -10.146  1    21.478  ? 112  ILE A N     1 ? 
ATOM   945   C  CA    . ILE A 1 112 ? -39.37  2.529   -8.831   1    20.967  ? 112  ILE A CA    1 ? 
ATOM   946   C  C     . ILE A 1 112 ? -40.822 3.028   -8.931   1    21.834  ? 112  ILE A C     1 ? 
ATOM   947   O  O     . ILE A 1 112 ? -41.725 2.392   -8.416   1    18.624  ? 112  ILE A O     1 ? 
ATOM   948   C  CB    . ILE A 1 112 ? -38.545 3.304   -7.776   1    19.742  ? 112  ILE A CB    1 ? 
ATOM   949   C  CG1   . ILE A 1 112 ? -37.144 2.602   -7.471   1    19.015  ? 112  ILE A CG1   1 ? 
ATOM   950   C  CG2   . ILE A 1 112 ? -39.33  3.519   -6.475   1    20.614  ? 112  ILE A CG2   1 ? 
ATOM   951   C  CD1   . ILE A 1 112 ? -36.175 3.49    -6.68    1    18.217  ? 112  ILE A CD1   1 ? 
ATOM   952   N  N     . LYS A 1 113 ? -41.013 4.161   -9.609   1    21.466  ? 113  LYS A N     1 ? 
ATOM   953   C  CA    . LYS A 1 113 ? -42.306 4.815   -9.725   1    26.756  ? 113  LYS A CA    1 ? 
ATOM   954   C  C     . LYS A 1 113 ? -43.258 3.834   -10.416  1    27.297  ? 113  LYS A C     1 ? 
ATOM   955   O  O     . LYS A 1 113 ? -44.374 3.646   -9.955   1    25.739  ? 113  LYS A O     1 ? 
ATOM   956   C  CB    . LYS A 1 113 ? -42.103 6.191   -10.382  1    29.345  ? 113  LYS A CB    1 ? 
ATOM   957   C  CG    . LYS A 1 113 ? -43.307 7.002   -10.883  1    37.931  ? 113  LYS A CG    1 ? 
ATOM   958   C  CD    . LYS A 1 113 ? -42.887 8.234   -11.673  1    41.639  ? 113  LYS A CD    1 ? 
ATOM   959   C  CE    . LYS A 1 113 ? -43.839 9.393   -11.523  1    62.668  ? 113  LYS A CE    1 ? 
ATOM   960   N  NZ    . LYS A 1 113 ? -45.22  9.16    -11.971  1    53.759  ? 113  LYS A NZ    1 ? 
ATOM   961   N  N     . LYS A 1 114 ? -42.778 3.171   -11.473  1    24.809  ? 114  LYS A N     1 ? 
ATOM   962   C  CA    . LYS A 1 114 ? -43.566 2.208   -12.232  1    28.353  ? 114  LYS A CA    1 ? 
ATOM   963   C  C     . LYS A 1 114 ? -43.897 0.953   -11.43   1    28.086  ? 114  LYS A C     1 ? 
ATOM   964   O  O     . LYS A 1 114 ? -44.99  0.401   -11.591  1    24.387  ? 114  LYS A O     1 ? 
ATOM   965   C  CB    . LYS A 1 114 ? -42.946 1.834   -13.578  1    33.47   ? 114  LYS A CB    1 ? 
ATOM   966   C  CG    . LYS A 1 114 ? -43.147 2.971   -14.569  1    40.224  ? 114  LYS A CG    1 ? 
ATOM   967   C  CD    . LYS A 1 114 ? -42.211 2.905   -15.77   1    47.508  ? 114  LYS A CD    1 ? 
ATOM   968   C  CE    . LYS A 1 114 ? -42.615 3.871   -16.864  1    56.584  ? 114  LYS A CE    1 ? 
ATOM   969   N  NZ    . LYS A 1 114 ? -43.047 5.194   -16.391  1    58.397  ? 114  LYS A NZ    1 ? 
ATOM   970   N  N     . ALA A 1 115 ? -42.949 0.468   -10.617  1    22.779  ? 115  ALA A N     1 ? 
ATOM   971   C  CA    . ALA A 1 115 ? -43.18  -0.704  -9.789   1    21.176  ? 115  ALA A CA    1 ? 
ATOM   972   C  C     . ALA A 1 115 ? -44.295 -0.414  -8.785   1    22.211  ? 115  ALA A C     1 ? 
ATOM   973   O  O     . ALA A 1 115 ? -45.17  -1.247  -8.553   1    21.082  ? 115  ALA A O     1 ? 
ATOM   974   C  CB    . ALA A 1 115 ? -41.916 -1.095  -9.04    1    20.99   ? 115  ALA A CB    1 ? 
ATOM   975   N  N     . ILE A 1 116 ? -44.256 0.79    -8.219   1    20.81   ? 116  ILE A N     1 ? 
ATOM   976   C  CA    . ILE A 1 116 ? -45.219 1.164   -7.206   1    20.951  ? 116  ILE A CA    1 ? 
ATOM   977   C  C     . ILE A 1 116 ? -46.593 1.381   -7.85    1    21.72   ? 116  ILE A C     1 ? 
ATOM   978   O  O     . ILE A 1 116 ? -47.604 1.081   -7.219   1    20.434  ? 116  ILE A O     1 ? 
ATOM   979   C  CB    . ILE A 1 116 ? -44.699 2.352   -6.37    1    24.663  ? 116  ILE A CB    1 ? 
ATOM   980   C  CG1   . ILE A 1 116 ? -43.536 1.866   -5.473   1    23.506  ? 116  ILE A CG1   1 ? 
ATOM   981   C  CG2   . ILE A 1 116 ? -45.838 2.938   -5.531   1    22.084  ? 116  ILE A CG2   1 ? 
ATOM   982   C  CD1   . ILE A 1 116 ? -42.897 2.94    -4.605   1    25.544  ? 116  ILE A CD1   1 ? 
ATOM   983   N  N     . GLU A 1 117 ? -46.622 1.808   -9.13    1    22.225  ? 117  GLU A N     1 ? 
ATOM   984   C  CA    . GLU A 1 117 ? -47.865 1.985   -9.88    1    24.576  ? 117  GLU A CA    1 ? 
ATOM   985   C  C     . GLU A 1 117 ? -48.601 0.657   -10.041  1    26.638  ? 117  GLU A C     1 ? 
ATOM   986   O  O     . GLU A 1 117 ? -49.834 0.636   -10.157  1    27.349  ? 117  GLU A O     1 ? 
ATOM   987   C  CB    . GLU A 1 117 ? -47.661 2.609   -11.261  1    24.514  ? 117  GLU A CB    1 ? 
ATOM   988   C  CG    . GLU A 1 117 ? -47.439 4.111   -11.152  1    29.134  ? 117  GLU A CG    1 ? 
ATOM   989   C  CD    . GLU A 1 117 ? -46.918 4.675   -12.458  1    34.726  ? 117  GLU A CD    1 ? 
ATOM   990   O  OE1   . GLU A 1 117 ? -46.78  5.925   -12.541  1    36.789  ? 117  GLU A OE1   1 ? 
ATOM   991   O  OE2   . GLU A 1 117 ? -46.692 3.852   -13.378  1    33.993  ? 117  GLU A OE2   1 ? 
ATOM   992   N  N     . LYS A 1 118 ? -47.847 -0.445  -10.044  1    24.783  ? 118  LYS A N     1 ? 
ATOM   993   C  CA    . LYS A 1 118 ? -48.405 -1.781  -10.169  1    25.983  ? 118  LYS A CA    1 ? 
ATOM   994   C  C     . LYS A 1 118 ? -48.635 -2.341  -8.777   1    26.809  ? 118  LYS A C     1 ? 
ATOM   995   O  O     . LYS A 1 118 ? -48.927 -3.522  -8.625   1    26.477  ? 118  LYS A O     1 ? 
ATOM   996   C  CB    . LYS A 1 118 ? -47.479 -2.701  -10.982  1    33.106  ? 118  LYS A CB    1 ? 
ATOM   997   C  CG    . LYS A 1 118 ? -47.246 -2.122  -12.364  1    37.47   ? 118  LYS A CG    1 ? 
ATOM   998   C  CD    . LYS A 1 118 ? -46.937 -3.012  -13.567  1    46.338  ? 118  LYS A CD    1 ? 
ATOM   999   C  CE    . LYS A 1 118 ? -45.504 -3.11   -13.957  1    50.392  ? 118  LYS A CE    1 ? 
ATOM   1000  N  NZ    . LYS A 1 118 ? -44.748 -3.399  -12.744  1    51.254  ? 118  LYS A NZ    1 ? 
ATOM   1001  N  N     . GLY A 1 119 ? -48.435 -1.503  -7.749   1    26.413  ? 119  GLY A N     1 ? 
ATOM   1002  C  CA    . GLY A 1 119 ? -48.719 -1.962  -6.402   1    24.939  ? 119  GLY A CA    1 ? 
ATOM   1003  C  C     . GLY A 1 119 ? -47.655 -2.895  -5.817   1    26.681  ? 119  GLY A C     1 ? 
ATOM   1004  O  O     . GLY A 1 119 ? -47.897 -3.508  -4.785   1    22.248  ? 119  GLY A O     1 ? 
ATOM   1005  N  N     . GLU A 1 120 ? -46.441 -2.927  -6.395   1    24.743  ? 120  GLU A N     1 ? 
ATOM   1006  C  CA    . GLU A 1 120 ? -45.34  -3.616  -5.728   1    25.114  ? 120  GLU A CA    1 ? 
ATOM   1007  C  C     . GLU A 1 120 ? -44.836 -2.862  -4.503   1    24.44   ? 120  GLU A C     1 ? 
ATOM   1008  O  O     . GLU A 1 120 ? -44.902 -1.631  -4.411   1    24.716  ? 120  GLU A O     1 ? 
ATOM   1009  C  CB    . GLU A 1 120 ? -44.15  -3.851  -6.659   1    26.099  ? 120  GLU A CB    1 ? 
ATOM   1010  C  CG    . GLU A 1 120 ? -44.535 -4.65   -7.906   1    29.728  ? 120  GLU A CG    1 ? 
ATOM   1011  C  CD    . GLU A 1 120 ? -43.441 -4.771  -8.962   1    35.917  ? 120  GLU A CD    1 ? 
ATOM   1012  O  OE1   . GLU A 1 120 ? -42.252 -4.673  -8.584   1    32.516  ? 120  GLU A OE1   1 ? 
ATOM   1013  O  OE2   . GLU A 1 120 ? -43.76  -4.89   -10.172  1    37.956  ? 120  GLU A OE2   1 ? 
ATOM   1014  N  N     . THR A 1 121 ? -44.318 -3.635  -3.551   1    24.167  ? 121  THR A N     1 ? 
ATOM   1015  C  CA    . THR A 1 121 ? -43.683 -3.081  -2.373   1    29.186  ? 121  THR A CA    1 ? 
ATOM   1016  C  C     . THR A 1 121 ? -42.195 -3.445  -2.421   1    30.842  ? 121  THR A C     1 ? 
ATOM   1017  O  O     . THR A 1 121 ? -41.824 -4.622  -2.489   1    26.755  ? 121  THR A O     1 ? 
ATOM   1018  C  CB    . THR A 1 121 ? -44.33  -3.606  -1.092   1    31.267  ? 121  THR A CB    1 ? 
ATOM   1019  O  OG1   . THR A 1 121 ? -45.751 -3.419  -1.111   1    38.519  ? 121  THR A OG1   1 ? 
ATOM   1020  C  CG2   . THR A 1 121 ? -43.759 -2.899  0.12     1    28.861  ? 121  THR A CG2   1 ? 
ATOM   1021  N  N     . LEU A 1 122 ? -41.363 -2.411  -2.347   1    29.194  ? 122  LEU A N     1 ? 
ATOM   1022  C  CA    . LEU A 1 122 ? -39.925 -2.546  -2.499   1    26.298  ? 122  LEU A CA    1 ? 
ATOM   1023  C  C     . LEU A 1 122 ? -39.318 -2.856  -1.148   1    25.871  ? 122  LEU A C     1 ? 
ATOM   1024  O  O     . LEU A 1 122 ? -39.859 -2.446  -0.115   1    28.298  ? 122  LEU A O     1 ? 
ATOM   1025  C  CB    . LEU A 1 122 ? -39.362 -1.257  -3.106   1    26.57   ? 122  LEU A CB    1 ? 
ATOM   1026  C  CG    . LEU A 1 122 ? -39.453 -1.262  -4.643   1    31.835  ? 122  LEU A CG    1 ? 
ATOM   1027  C  CD1   . LEU A 1 122 ? -40.877 -1.254  -5.149   1    28.771  ? 122  LEU A CD1   1 ? 
ATOM   1028  C  CD2   . LEU A 1 122 ? -38.678 -0.187  -5.359   1    26.958  ? 122  LEU A CD2   1 ? 
ATOM   1029  N  N     . PRO A 1 123 ? -38.095 -3.433  -1.131   1    28.43   ? 123  PRO A N     1 ? 
ATOM   1030  C  CA    . PRO A 1 123 ? -37.361 -3.608  0.126    1    26.279  ? 123  PRO A CA    1 ? 
ATOM   1031  C  C     . PRO A 1 123 ? -37.217 -2.241  0.774    1    29.13   ? 123  PRO A C     1 ? 
ATOM   1032  O  O     . PRO A 1 123 ? -37.094 -1.24   0.07     1    27.267  ? 123  PRO A O     1 ? 
ATOM   1033  C  CB    . PRO A 1 123 ? -36.034 -4.159  -0.424   1    27.261  ? 123  PRO A CB    1 ? 
ATOM   1034  C  CG    . PRO A 1 123 ? -36.44  -4.879  -1.691   1    24.381  ? 123  PRO A CG    1 ? 
ATOM   1035  C  CD    . PRO A 1 123 ? -37.347 -3.856  -2.333   1    24.162  ? 123  PRO A CD    1 ? 
ATOM   1036  N  N     . THR A 1 124 ? -37.254 -2.17   2.113    1    33.434  ? 124  THR A N     1 ? 
ATOM   1037  C  CA    . THR A 1 124 ? -37.074 -0.875  2.765    1    35.165  ? 124  THR A CA    1 ? 
ATOM   1038  C  C     . THR A 1 124 ? -35.593 -0.465  2.794    1    32.808  ? 124  THR A C     1 ? 
ATOM   1039  O  O     . THR A 1 124 ? -35.289 0.722   2.92     1    34.841  ? 124  THR A O     1 ? 
ATOM   1040  C  CB    . THR A 1 124 ? -37.673 -0.807  4.181    1    39.915  ? 124  THR A CB    1 ? 
ATOM   1041  O  OG1   . THR A 1 124 ? -37.279 -2.009  4.831    1    44.119  ? 124  THR A OG1   1 ? 
ATOM   1042  C  CG2   . THR A 1 124 ? -39.187 -0.711  4.244    1    37.791  ? 124  THR A CG2   1 ? 
ATOM   1043  N  N     . GLU A 1 125 ? -34.659 -1.416  2.716    1    31.796  ? 125  GLU A N     1 ? 
ATOM   1044  C  CA    . GLU A 1 125 ? -33.25  -1.04   2.595    1    39.164  ? 125  GLU A CA    1 ? 
ATOM   1045  C  C     . GLU A 1 125 ? -32.983 -0.429  1.208    1    35.324  ? 125  GLU A C     1 ? 
ATOM   1046  O  O     . GLU A 1 125 ? -33.504 -0.901  0.197    1    32.857  ? 125  GLU A O     1 ? 
ATOM   1047  C  CB    . GLU A 1 125 ? -32.324 -2.242  2.826    1    39.716  ? 125  GLU A CB    1 ? 
ATOM   1048  C  CG    . GLU A 1 125 ? -32.42  -3.27   1.698    1    50.047  ? 125  GLU A CG    1 ? 
ATOM   1049  C  CD    . GLU A 1 125 ? -32.119 -4.75   1.963    1    69.31   ? 125  GLU A CD    1 ? 
ATOM   1050  O  OE1   . GLU A 1 125 ? -33.073 -5.6    1.923    1    52.724  ? 125  GLU A OE1   1 ? 
ATOM   1051  O  OE2   . GLU A 1 125 ? -30.905 -5.056  2.166    1    69.492  ? 125  GLU A OE2   1 ? 
ATOM   1052  N  N     . ALA A 1 126 ? -32.117 0.594   1.18     1    32.045  ? 126  ALA A N     1 ? 
ATOM   1053  C  CA    . ALA A 1 126 ? -31.788 1.379   0.001    1    30.29   ? 126  ALA A CA    1 ? 
ATOM   1054  C  C     . ALA A 1 126 ? -31.154 0.51    -1.089   1    24.636  ? 126  ALA A C     1 ? 
ATOM   1055  O  O     . ALA A 1 126 ? -30.447 -0.447  -0.813   1    26.95   ? 126  ALA A O     1 ? 
ATOM   1056  C  CB    . ALA A 1 126 ? -30.886 2.534   0.424    1    35.501  ? 126  ALA A CB    1 ? 
ATOM   1057  N  N     . ARG A 1 127 ? -31.502 0.774   -2.343   1    23.134  ? 127  ARG A N     1 ? 
ATOM   1058  C  CA    . ARG A 1 127 ? -30.861 0.073   -3.429   1    23.572  ? 127  ARG A CA    1 ? 
ATOM   1059  C  C     . ARG A 1 127 ? -29.397 0.539   -3.532   1    21.85   ? 127  ARG A C     1 ? 
ATOM   1060  O  O     . ARG A 1 127 ? -28.995 1.555   -2.946   1    21.036  ? 127  ARG A O     1 ? 
ATOM   1061  C  CB    . ARG A 1 127 ? -31.575 0.46    -4.718   1    24.552  ? 127  ARG A CB    1 ? 
ATOM   1062  C  CG    . ARG A 1 127 ? -31.419 1.918   -5.094   1    25.912  ? 127  ARG A CG    1 ? 
ATOM   1063  C  CD    . ARG A 1 127 ? -32.038 1.966   -6.493   1    25.495  ? 127  ARG A CD    1 ? 
ATOM   1064  N  NE    . ARG A 1 127 ? -31.535 3.279   -6.865   1    33.699  ? 127  ARG A NE    1 ? 
ATOM   1065  C  CZ    . ARG A 1 127 ? -30.595 3.346   -7.773   1    30.11   ? 127  ARG A CZ    1 ? 
ATOM   1066  N  NH1   . ARG A 1 127 ? -30.372 2.299   -8.562   1    28.864  ? 127  ARG A NH1   1 ? 
ATOM   1067  N  NH2   . ARG A 1 127 ? -29.932 4.461   -7.879   1    35.027  ? 127  ARG A NH2   1 ? 
ATOM   1068  N  N     . PHE A 1 128 ? -28.621 -0.187  -4.316   1    23.263  ? 128  PHE A N     1 ? 
ATOM   1069  C  CA    . PHE A 1 128 ? -27.248 0.25    -4.501   1    21.305  ? 128  PHE A CA    1 ? 
ATOM   1070  C  C     . PHE A 1 128 ? -27.23  1.406   -5.491   1    19.681  ? 128  PHE A C     1 ? 
ATOM   1071  O  O     . PHE A 1 128 ? -27.697 1.258   -6.617   1    21.266  ? 128  PHE A O     1 ? 
ATOM   1072  C  CB    . PHE A 1 128 ? -26.498 -0.936  -5.075   1    20.673  ? 128  PHE A CB    1 ? 
ATOM   1073  C  CG    . PHE A 1 128 ? -25.021 -0.617  -5.311   1    20.092  ? 128  PHE A CG    1 ? 
ATOM   1074  C  CD1   . PHE A 1 128 ? -24.094 -0.773  -4.285   1    21.051  ? 128  PHE A CD1   1 ? 
ATOM   1075  C  CD2   . PHE A 1 128 ? -24.57  -0.256  -6.579   1    17.592  ? 128  PHE A CD2   1 ? 
ATOM   1076  C  CE1   . PHE A 1 128 ? -22.739 -0.538  -4.513   1    22.76   ? 128  PHE A CE1   1 ? 
ATOM   1077  C  CE2   . PHE A 1 128 ? -23.212 -0.03   -6.811   1    15.704  ? 128  PHE A CE2   1 ? 
ATOM   1078  C  CZ    . PHE A 1 128 ? -22.322 -0.121  -5.756   1    16.602  ? 128  PHE A CZ    1 ? 
ATOM   1079  N  N     . ASP A 1 129 ? -26.693 2.553   -5.07    1    18.061  ? 129  ASP A N     1 ? 
ATOM   1080  C  CA    . ASP A 1 129 ? -26.614 3.685   -5.993   1    18.695  ? 129  ASP A CA    1 ? 
ATOM   1081  C  C     . ASP A 1 129 ? -25.336 3.564   -6.823   1    19.221  ? 129  ASP A C     1 ? 
ATOM   1082  O  O     . ASP A 1 129 ? -24.224 3.756   -6.288   1    20.726  ? 129  ASP A O     1 ? 
ATOM   1083  C  CB    . ASP A 1 129 ? -26.615 5.008   -5.222   1    18.442  ? 129  ASP A CB    1 ? 
ATOM   1084  C  CG    . ASP A 1 129 ? -26.576 6.252   -6.123   1    20.987  ? 129  ASP A CG    1 ? 
ATOM   1085  O  OD1   . ASP A 1 129 ? -26.511 6.094   -7.364   1    18.005  ? 129  ASP A OD1   1 ? 
ATOM   1086  O  OD2   . ASP A 1 129 ? -26.696 7.385   -5.598   1    22.322  ? 129  ASP A OD2   1 ? 
ATOM   1087  N  N     . SER A 1 130 ? -25.479 3.206   -8.109   1    18.59   ? 130  SER A N     1 ? 
ATOM   1088  C  CA    . SER A 1 130 ? -24.315 2.975   -8.944   1    20.51   ? 130  SER A CA    1 ? 
ATOM   1089  C  C     . SER A 1 130 ? -23.453 4.238   -9.102   1    21.004  ? 130  SER A C     1 ? 
ATOM   1090  O  O     . SER A 1 130 ? -22.272 4.134   -9.437   1    21.606  ? 130  SER A O     1 ? 
ATOM   1091  C  CB    . SER A 1 130 ? -24.694 2.36    -10.274  1    19.498  ? 130  SER A CB    1 ? 
ATOM   1092  O  OG    . SER A 1 130 ? -25.41  3.268   -11.098  1    22.155  ? 130  SER A OG    1 ? 
ATOM   1093  N  N     . ASN A 1 131 ? -24.019 5.423   -8.819   1    19.797  ? 131  ASN A N     1 ? 
ATOM   1094  C  CA    . ASN A 1 131 ? -23.244 6.654   -8.835   1    17.47   ? 131  ASN A CA    1 ? 
ATOM   1095  C  C     . ASN A 1 131 ? -22.121 6.579   -7.806   1    17.146  ? 131  ASN A C     1 ? 
ATOM   1096  O  O     . ASN A 1 131 ? -21.236 7.447   -7.825   1    17.339  ? 131  ASN A O     1 ? 
ATOM   1097  C  CB    . ASN A 1 131 ? -24.09  7.905   -8.623   1    13.959  ? 131  ASN A CB    1 ? 
ATOM   1098  C  CG    . ASN A 1 131 ? -25.005 8.171   -9.793   1    14      ? 131  ASN A CG    1 ? 
ATOM   1099  O  OD1   . ASN A 1 131 ? -24.844 7.575   -10.863  1    15.61   ? 131  ASN A OD1   1 ? 
ATOM   1100  N  ND2   . ASN A 1 131 ? -26.013 9.021   -9.586   1    12.295  ? 131  ASN A ND2   1 ? 
ATOM   1101  N  N     . CYS A 1 132 ? -22.212 5.622   -6.864   1    15.261  ? 132  CYS A N     1 ? 
ATOM   1102  C  CA    . CYS A 1 132 ? -21.144 5.519   -5.873   1    15.669  ? 132  CYS A CA    1 ? 
ATOM   1103  C  C     . CYS A 1 132 ? -19.834 5.013   -6.515   1    16.055  ? 132  CYS A C     1 ? 
ATOM   1104  O  O     . CYS A 1 132 ? -18.806 5.053   -5.867   1    17.105  ? 132  CYS A O     1 ? 
ATOM   1105  C  CB    . CYS A 1 132 ? -21.53  4.718   -4.632   1    15.785  ? 132  CYS A CB    1 ? 
ATOM   1106  S  SG    . CYS A 1 132 ? -21.516 2.933   -4.917   1    18.88   ? 132  CYS A SG    1 ? 
ATOM   1107  N  N     . ILE A 1 133 ? -19.878 4.5     -7.751   1    14.774  ? 133  ILE A N     1 ? 
ATOM   1108  C  CA    . ILE A 1 133 ? -18.669 4.066   -8.433   1    16.324  ? 133  ILE A CA    1 ? 
ATOM   1109  C  C     . ILE A 1 133 ? -18.004 5.284   -9.09    1    15.019  ? 133  ILE A C     1 ? 
ATOM   1110  O  O     . ILE A 1 133 ? -18.084 5.469   -10.309  1    15.999  ? 133  ILE A O     1 ? 
ATOM   1111  C  CB    . ILE A 1 133 ? -18.925 2.913   -9.429   1    16.165  ? 133  ILE A CB    1 ? 
ATOM   1112  C  CG1   . ILE A 1 133 ? -19.707 1.76    -8.739   1    16.054  ? 133  ILE A CG1   1 ? 
ATOM   1113  C  CG2   . ILE A 1 133 ? -17.57  2.441   -9.961   1    16.346  ? 133  ILE A CG2   1 ? 
ATOM   1114  C  CD1   . ILE A 1 133 ? -20.343 0.753   -9.688   1    17.761  ? 133  ILE A CD1   1 ? 
ATOM   1115  N  N     . THR A 1 134 ? -17.37  6.094   -8.236   1    14.682  ? 134  THR A N     1 ? 
ATOM   1116  C  CA    . THR A 1 134 ? -16.811 7.401   -8.589   1    16.255  ? 134  THR A CA    1 ? 
ATOM   1117  C  C     . THR A 1 134 ? -15.686 7.588   -7.591   1    17.199  ? 134  THR A C     1 ? 
ATOM   1118  O  O     . THR A 1 134 ? -15.824 7.114   -6.472   1    16.76   ? 134  THR A O     1 ? 
ATOM   1119  C  CB    . THR A 1 134 ? -17.871 8.5     -8.412   1    16.405  ? 134  THR A CB    1 ? 
ATOM   1120  O  OG1   . THR A 1 134 ? -19.019 8.162   -9.185   1    16.813  ? 134  THR A OG1   1 ? 
ATOM   1121  C  CG2   . THR A 1 134 ? -17.434 9.819   -9.02    1    16.8    ? 134  THR A CG2   1 ? 
ATOM   1122  N  N     . PRO A 1 135 ? -14.508 8.147   -7.953   1    16.527  ? 135  PRO A N     1 ? 
ATOM   1123  C  CA    . PRO A 1 135 ? -13.415 8.177   -6.977   1    15.246  ? 135  PRO A CA    1 ? 
ATOM   1124  C  C     . PRO A 1 135 ? -13.823 8.907   -5.708   1    15.616  ? 135  PRO A C     1 ? 
ATOM   1125  O  O     . PRO A 1 135 ? -14.567 9.896   -5.76    1    17.892  ? 135  PRO A O     1 ? 
ATOM   1126  C  CB    . PRO A 1 135 ? -12.283 8.898   -7.722   1    15.962  ? 135  PRO A CB    1 ? 
ATOM   1127  C  CG    . PRO A 1 135 ? -12.565 8.591   -9.184   1    14.918  ? 135  PRO A CG    1 ? 
ATOM   1128  C  CD    . PRO A 1 135 ? -14.119 8.609   -9.302   1    15.146  ? 135  PRO A CD    1 ? 
ATOM   1129  N  N     . GLY A 1 136 ? -13.39  8.347   -4.584   1    14.515  ? 136  GLY A N     1 ? 
ATOM   1130  C  CA    . GLY A 1 136 ? -13.397 8.973   -3.272   1    16.577  ? 136  GLY A CA    1 ? 
ATOM   1131  C  C     . GLY A 1 136 ? -14.688 8.742   -2.476   1    16.979  ? 136  GLY A C     1 ? 
ATOM   1132  O  O     . GLY A 1 136 ? -14.79  9.302   -1.417   1    16.174  ? 136  GLY A O     1 ? 
ATOM   1133  N  N     . THR A 1 137 ? -15.678 8.013   -3.03    1    15.898  ? 137  THR A N     1 ? 
ATOM   1134  C  CA    . THR A 1 137 ? -16.809 7.574   -2.22    1    17.363  ? 137  THR A CA    1 ? 
ATOM   1135  C  C     . THR A 1 137 ? -16.375 6.599   -1.129   1    19.525  ? 137  THR A C     1 ? 
ATOM   1136  O  O     . THR A 1 137 ? -15.295 6.016   -1.179   1    18.09   ? 137  THR A O     1 ? 
ATOM   1137  C  CB    . THR A 1 137 ? -17.95  7.022   -3.062   1    15.265  ? 137  THR A CB    1 ? 
ATOM   1138  O  OG1   . THR A 1 137 ? -17.464 5.834   -3.685   1    13.464  ? 137  THR A OG1   1 ? 
ATOM   1139  C  CG2   . THR A 1 137 ? -18.384 8.008   -4.149   1    14.228  ? 137  THR A CG2   1 ? 
ATOM   1140  N  N     . GLU A 1 138 ? -17.243 6.454   -0.125   1    17.097  ? 138  GLU A N     1 ? 
ATOM   1141  C  CA    . GLU A 1 138 ? -17.046 5.511   0.959    1    19.767  ? 138  GLU A CA    1 ? 
ATOM   1142  C  C     . GLU A 1 138 ? -16.972 4.112   0.355    1    19.351  ? 138  GLU A C     1 ? 
ATOM   1143  O  O     . GLU A 1 138 ? -16.114 3.323   0.753    1    22.406  ? 138  GLU A O     1 ? 
ATOM   1144  C  CB    . GLU A 1 138 ? -18.187 5.555   1.983    1    21.424  ? 138  GLU A CB    1 ? 
ATOM   1145  C  CG    . GLU A 1 138 ? -18.155 6.822   2.813    1    27.429  ? 138  GLU A CG    1 ? 
ATOM   1146  C  CD    . GLU A 1 138 ? -19.121 6.754   3.993    1    33.885  ? 138  GLU A CD    1 ? 
ATOM   1147  O  OE1   . GLU A 1 138 ? -20.322 6.973   3.793    1    37.133  ? 138  GLU A OE1   1 ? 
ATOM   1148  O  OE2   . GLU A 1 138 ? -18.669 6.453   5.108    1    42.76   ? 138  GLU A OE2   1 ? 
ATOM   1149  N  N     . PHE A 1 139 ? -17.825 3.849   -0.631   1    16.394  ? 139  PHE A N     1 ? 
ATOM   1150  C  CA    . PHE A 1 139 ? -17.873 2.549   -1.278   1    18.3    ? 139  PHE A CA    1 ? 
ATOM   1151  C  C     . PHE A 1 139 ? -16.565 2.277   -2.029   1    18.58   ? 139  PHE A C     1 ? 
ATOM   1152  O  O     . PHE A 1 139 ? -16.008 1.202   -1.908   1    19.464  ? 139  PHE A O     1 ? 
ATOM   1153  C  CB    . PHE A 1 139 ? -19.099 2.316   -2.173   1    15.399  ? 139  PHE A CB    1 ? 
ATOM   1154  C  CG    . PHE A 1 139 ? -18.963 1.069   -3.031   1    18.529  ? 139  PHE A CG    1 ? 
ATOM   1155  C  CD1   . PHE A 1 139 ? -19.311 -0.183  -2.534   1    16.625  ? 139  PHE A CD1   1 ? 
ATOM   1156  C  CD2   . PHE A 1 139 ? -18.441 1.156   -4.327   1    20.137  ? 139  PHE A CD2   1 ? 
ATOM   1157  C  CE1   . PHE A 1 139 ? -19.136 -1.33   -3.31    1    16.603  ? 139  PHE A CE1   1 ? 
ATOM   1158  C  CE2   . PHE A 1 139 ? -18.252 0.006   -5.099   1    17.488  ? 139  PHE A CE2   1 ? 
ATOM   1159  C  CZ    . PHE A 1 139 ? -18.594 -1.235  -4.576   1    16.638  ? 139  PHE A CZ    1 ? 
ATOM   1160  N  N     . MET A 1 140 ? -16.029 3.263   -2.749   1    18.354  ? 140  MET A N     1 ? 
ATOM   1161  C  CA    . MET A 1 140 ? -14.765 3.078   -3.457   1    16.055  ? 140  MET A CA    1 ? 
ATOM   1162  C  C     . MET A 1 140 ? -13.579 2.929   -2.509   1    16.198  ? 140  MET A C     1 ? 
ATOM   1163  O  O     . MET A 1 140 ? -12.617 2.225   -2.838   1    16.588  ? 140  MET A O     1 ? 
ATOM   1164  C  CB    . MET A 1 140 ? -14.529 4.164   -4.516   1    16.679  ? 140  MET A CB    1 ? 
ATOM   1165  C  CG    . MET A 1 140 ? -15.471 4.024   -5.727   1    19.405  ? 140  MET A CG    1 ? 
ATOM   1166  S  SD    . MET A 1 140 ? -15.206 2.55    -6.729   1    18.897  ? 140  MET A SD    1 ? 
ATOM   1167  C  CE    . MET A 1 140 ? -14.187 3.168   -8.059   1    16.951  ? 140  MET A CE    1 ? 
ATOM   1168  N  N     . ALA A 1 141 ? -13.597 3.603   -1.354   1    17.374  ? 141  ALA A N     1 ? 
ATOM   1169  C  CA    . ALA A 1 141 ? -12.49  3.442   -0.419   1    16.157  ? 141  ALA A CA    1 ? 
ATOM   1170  C  C     . ALA A 1 141 ? -12.545 2.02    0.177    1    17.552  ? 141  ALA A C     1 ? 
ATOM   1171  O  O     . ALA A 1 141 ? -11.504 1.391   0.407    1    18.396  ? 141  ALA A O     1 ? 
ATOM   1172  C  CB    . ALA A 1 141 ? -12.543 4.491   0.701    1    17.271  ? 141  ALA A CB    1 ? 
ATOM   1173  N  N     . ARG A 1 142 ? -13.746 1.518   0.504    1    15.964  ? 142  ARG A N     1 ? 
ATOM   1174  C  CA    A ARG A 1 142 ? -13.879 0.155   1.02     0.5  15.699  ? 142  ARG A CA    1 ? 
ATOM   1175  C  CA    B ARG A 1 142 ? -13.865 0.156   1.022    0.5  16.283  ? 142  ARG A CA    1 ? 
ATOM   1176  C  C     . ARG A 1 142 ? -13.39  -0.828  -0.036   1    16.751  ? 142  ARG A C     1 ? 
ATOM   1177  O  O     . ARG A 1 142 ? -12.647 -1.755  0.273    1    18.655  ? 142  ARG A O     1 ? 
ATOM   1178  C  CB    A ARG A 1 142 ? -15.307 -0.222  1.45     0.5  16.149  ? 142  ARG A CB    1 ? 
ATOM   1179  C  CB    B ARG A 1 142 ? -15.3   -0.201  1.428    0.5  17.86   ? 142  ARG A CB    1 ? 
ATOM   1180  C  CG    A ARG A 1 142 ? -15.909 0.49    2.657    0.5  16.666  ? 142  ARG A CG    1 ? 
ATOM   1181  C  CG    B ARG A 1 142 ? -15.425 -1.392  2.368    0.5  20.28   ? 142  ARG A CG    1 ? 
ATOM   1182  C  CD    A ARG A 1 142 ? -17.228 -0.145  3.185    0.5  17.478  ? 142  ARG A CD    1 ? 
ATOM   1183  C  CD    B ARG A 1 142 ? -16.885 -1.6    2.764    0.5  20.881  ? 142  ARG A CD    1 ? 
ATOM   1184  N  NE    A ARG A 1 142 ? -18.379 -0.072  2.258    0.5  19.927  ? 142  ARG A NE    1 ? 
ATOM   1185  N  NE    B ARG A 1 142 ? -16.932 -2.352  4.02     0.5  26.595  ? 142  ARG A NE    1 ? 
ATOM   1186  C  CZ    A ARG A 1 142 ? -19.126 1.01    2.078    0.5  17.604  ? 142  ARG A CZ    1 ? 
ATOM   1187  C  CZ    B ARG A 1 142 ? -18.013 -2.503  4.772    0.5  25.059  ? 142  ARG A CZ    1 ? 
ATOM   1188  N  NH1   A ARG A 1 142 ? -18.857 2.108   2.76     0.5  20.369  ? 142  ARG A NH1   1 ? 
ATOM   1189  N  NH1   B ARG A 1 142 ? -19.205 -2.149  4.326    0.5  24.821  ? 142  ARG A NH1   1 ? 
ATOM   1190  N  NH2   A ARG A 1 142 ? -20.13  1.018   1.236    0.5  15.575  ? 142  ARG A NH2   1 ? 
ATOM   1191  N  NH2   B ARG A 1 142 ? -17.878 -3.028  5.967    0.5  27.351  ? 142  ARG A NH2   1 ? 
ATOM   1192  N  N     . LEU A 1 143 ? -13.847 -0.637  -1.288   1    14.443  ? 143  LEU A N     1 ? 
ATOM   1193  C  CA    . LEU A 1 143 ? -13.483 -1.541  -2.356   1    16.163  ? 143  LEU A CA    1 ? 
ATOM   1194  C  C     . LEU A 1 143 ? -11.958 -1.571  -2.541   1    16.542  ? 143  LEU A C     1 ? 
ATOM   1195  O  O     . LEU A 1 143 ? -11.367 -2.613  -2.854   1    14.74   ? 143  LEU A O     1 ? 
ATOM   1196  C  CB    . LEU A 1 143 ? -14.174 -1.119  -3.651   1    13.584  ? 143  LEU A CB    1 ? 
ATOM   1197  C  CG    . LEU A 1 143 ? -13.704 -1.872  -4.897   1    14.711  ? 143  LEU A CG    1 ? 
ATOM   1198  C  CD1   . LEU A 1 143 ? -13.806 -3.395  -4.766   1    14.058  ? 143  LEU A CD1   1 ? 
ATOM   1199  C  CD2   . LEU A 1 143 ? -14.466 -1.482  -6.181   1    16.806  ? 143  LEU A CD2   1 ? 
ATOM   1200  N  N     . HIS A 1 144 ? -11.35  -0.399  -2.455   1    16.611  ? 144  HIS A N     1 ? 
ATOM   1201  C  CA    . HIS A 1 144 ? -9.917  -0.216  -2.675   1    18.103  ? 144  HIS A CA    1 ? 
ATOM   1202  C  C     . HIS A 1 144 ? -9.151  -1.058  -1.642   1    20.506  ? 144  HIS A C     1 ? 
ATOM   1203  O  O     . HIS A 1 144 ? -8.171  -1.727  -1.981   1    22.97   ? 144  HIS A O     1 ? 
ATOM   1204  C  CB    . HIS A 1 144 ? -9.591  1.288   -2.561   1    16.754  ? 144  HIS A CB    1 ? 
ATOM   1205  C  CG    . HIS A 1 144 ? -8.136  1.599   -2.74    1    18.352  ? 144  HIS A CG    1 ? 
ATOM   1206  N  ND1   . HIS A 1 144 ? -7.547  1.553   -3.981   1    17.648  ? 144  HIS A ND1   1 ? 
ATOM   1207  C  CD2   . HIS A 1 144 ? -7.175  1.945   -1.872   1    19.525  ? 144  HIS A CD2   1 ? 
ATOM   1208  C  CE1   . HIS A 1 144 ? -6.249  1.812   -3.857   1    19.968  ? 144  HIS A CE1   1 ? 
ATOM   1209  N  NE2   . HIS A 1 144 ? -5.999  2.054   -2.58    1    19.262  ? 144  HIS A NE2   1 ? 
ATOM   1210  N  N     . GLU A 1 145 ? -9.566  -0.95   -0.371   1    18.841  ? 145  GLU A N     1 ? 
ATOM   1211  C  CA    . GLU A 1 145 ? -8.987  -1.742  0.705    1    23.819  ? 145  GLU A CA    1 ? 
ATOM   1212  C  C     . GLU A 1 145 ? -9.066  -3.239  0.39     1    22.283  ? 145  GLU A C     1 ? 
ATOM   1213  O  O     . GLU A 1 145 ? -8.096  -3.981  0.597    1    18.062  ? 145  GLU A O     1 ? 
ATOM   1214  C  CB    . GLU A 1 145 ? -9.624  -1.438  2.062    1    24.183  ? 145  GLU A CB    1 ? 
ATOM   1215  C  CG    . GLU A 1 145 ? -9.316  -0.044  2.612    1    28.771  ? 145  GLU A CG    1 ? 
ATOM   1216  C  CD    . GLU A 1 145 ? -7.825  0.306   2.635    1    35.117  ? 145  GLU A CD    1 ? 
ATOM   1217  O  OE1   . GLU A 1 145 ? -6.995  -0.507  3.092    1    42.289  ? 145  GLU A OE1   1 ? 
ATOM   1218  O  OE2   . GLU A 1 145 ? -7.482  1.419   2.2      1    37.747  ? 145  GLU A OE2   1 ? 
ATOM   1219  N  N     . HIS A 1 146 ? -10.235 -3.683  -0.089   1    19.203  ? 146  HIS A N     1 ? 
ATOM   1220  C  CA    . HIS A 1 146 ? -10.447 -5.078  -0.454   1    16.962  ? 146  HIS A CA    1 ? 
ATOM   1221  C  C     . HIS A 1 146 ? -9.584  -5.489  -1.643   1    16.79   ? 146  HIS A C     1 ? 
ATOM   1222  O  O     . HIS A 1 146 ? -9.157  -6.639  -1.731   1    18.514  ? 146  HIS A O     1 ? 
ATOM   1223  C  CB    . HIS A 1 146 ? -11.939 -5.35   -0.728   1    15.921  ? 146  HIS A CB    1 ? 
ATOM   1224  C  CG    . HIS A 1 146 ? -12.696 -5.439  0.56     1    16.658  ? 146  HIS A CG    1 ? 
ATOM   1225  N  ND1   . HIS A 1 146 ? -12.97  -4.314  1.306    1    17.394  ? 146  HIS A ND1   1 ? 
ATOM   1226  C  CD2   . HIS A 1 146 ? -13.114 -6.499  1.312    1    15.956  ? 146  HIS A CD2   1 ? 
ATOM   1227  C  CE1   . HIS A 1 146 ? -13.51  -4.664  2.476    1    16.807  ? 146  HIS A CE1   1 ? 
ATOM   1228  N  NE2   . HIS A 1 146 ? -13.675 -5.981  2.469    1    16.786  ? 146  HIS A NE2   1 ? 
ATOM   1229  N  N     . LEU A 1 147 ? -9.358  -4.593  -2.61    1    16.061  ? 147  LEU A N     1 ? 
ATOM   1230  C  CA    . LEU A 1 147 ? -8.613  -5.033  -3.782   1    16.167  ? 147  LEU A CA    1 ? 
ATOM   1231  C  C     . LEU A 1 147 ? -7.121  -5.195  -3.44    1    17.008  ? 147  LEU A C     1 ? 
ATOM   1232  O  O     . LEU A 1 147 ? -6.453  -6.101  -3.957   1    18.482  ? 147  LEU A O     1 ? 
ATOM   1233  C  CB    . LEU A 1 147 ? -8.824  -4.02   -4.911   1    15.753  ? 147  LEU A CB    1 ? 
ATOM   1234  C  CG    . LEU A 1 147 ? -10.194 -4.06   -5.627   1    17.879  ? 147  LEU A CG    1 ? 
ATOM   1235  C  CD1   . LEU A 1 147 ? -10.253 -2.873  -6.61    1    18.388  ? 147  LEU A CD1   1 ? 
ATOM   1236  C  CD2   . LEU A 1 147 ? -10.363 -5.325  -6.41    1    16.411  ? 147  LEU A CD2   1 ? 
ATOM   1237  N  N     . LYS A 1 148 ? -6.608  -4.308  -2.587   1    17.055  ? 148  LYS A N     1 ? 
ATOM   1238  C  CA    . LYS A 1 148 ? -5.244  -4.437  -2.071   1    19.374  ? 148  LYS A CA    1 ? 
ATOM   1239  C  C     . LYS A 1 148 ? -5.126  -5.749  -1.295   1    19.37   ? 148  LYS A C     1 ? 
ATOM   1240  O  O     . LYS A 1 148 ? -4.158  -6.48   -1.45    1    17.823  ? 148  LYS A O     1 ? 
ATOM   1241  C  CB    . LYS A 1 148 ? -4.852  -3.3    -1.137   1    16.433  ? 148  LYS A CB    1 ? 
ATOM   1242  C  CG    . LYS A 1 148 ? -4.733  -1.962  -1.896   1    18.408  ? 148  LYS A CG    1 ? 
ATOM   1243  C  CD    . LYS A 1 148 ? -4.084  -0.833  -1.113   1    18.96   ? 148  LYS A CD    1 ? 
ATOM   1244  C  CE    . LYS A 1 148 ? -4.67   -0.764  0.246    1    21.933  ? 148  LYS A CE    1 ? 
ATOM   1245  N  NZ    . LYS A 1 148 ? -4.142  0.386   1.018    1    22.76   ? 148  LYS A NZ    1 ? 
ATOM   1246  N  N     . TYR A 1 149 ? -6.15   -6.064  -0.496   1    18.077  ? 149  TYR A N     1 ? 
ATOM   1247  C  CA    . TYR A 1 149 ? -6.144  -7.297  0.286    1    17.722  ? 149  TYR A CA    1 ? 
ATOM   1248  C  C     . TYR A 1 149 ? -6.094  -8.498  -0.666   1    19.984  ? 149  TYR A C     1 ? 
ATOM   1249  O  O     . TYR A 1 149 ? -5.326  -9.444  -0.467   1    21.877  ? 149  TYR A O     1 ? 
ATOM   1250  C  CB    . TYR A 1 149 ? -7.443  -7.337  1.101    1    17.457  ? 149  TYR A CB    1 ? 
ATOM   1251  C  CG    . TYR A 1 149 ? -7.81   -8.709  1.671    1    20.816  ? 149  TYR A CG    1 ? 
ATOM   1252  C  CD1   . TYR A 1 149 ? -7.187  -9.209  2.822    1    23.167  ? 149  TYR A CD1   1 ? 
ATOM   1253  C  CD2   . TYR A 1 149 ? -8.844  -9.463  1.111    1    21.613  ? 149  TYR A CD2   1 ? 
ATOM   1254  C  CE1   . TYR A 1 149 ? -7.583  -10.42  3.385    1    25.139  ? 149  TYR A CE1   1 ? 
ATOM   1255  C  CE2   . TYR A 1 149 ? -9.253  -10.67  1.671    1    24.942  ? 149  TYR A CE2   1 ? 
ATOM   1256  C  CZ    . TYR A 1 149 ? -8.633  -11.136 2.825    1    26.599  ? 149  TYR A CZ    1 ? 
ATOM   1257  O  OH    . TYR A 1 149 ? -9.039  -12.335 3.34     1    26.984  ? 149  TYR A OH    1 ? 
ATOM   1258  N  N     . PHE A 1 150 ? -6.877  -8.432  -1.75    1    18.774  ? 150  PHE A N     1 ? 
ATOM   1259  C  CA    . PHE A 1 150 ? -6.978  -9.526  -2.692   1    21.112  ? 150  PHE A CA    1 ? 
ATOM   1260  C  C     . PHE A 1 150 ? -5.621  -9.764  -3.372   1    23.772  ? 150  PHE A C     1 ? 
ATOM   1261  O  O     . PHE A 1 150 ? -5.213  -10.899 -3.523   1    25.083  ? 150  PHE A O     1 ? 
ATOM   1262  C  CB    . PHE A 1 150 ? -8.032  -9.139  -3.727   1    23.112  ? 150  PHE A CB    1 ? 
ATOM   1263  C  CG    . PHE A 1 150 ? -8.083  -10.124 -4.889   1    24.551  ? 150  PHE A CG    1 ? 
ATOM   1264  C  CD1   . PHE A 1 150 ? -8.736  -11.338 -4.759   1    24.338  ? 150  PHE A CD1   1 ? 
ATOM   1265  C  CD2   . PHE A 1 150 ? -7.426  -9.844  -6.081   1    26.538  ? 150  PHE A CD2   1 ? 
ATOM   1266  C  CE1   . PHE A 1 150 ? -8.76   -12.253 -5.805   1    25.772  ? 150  PHE A CE1   1 ? 
ATOM   1267  C  CE2   . PHE A 1 150 ? -7.458  -10.745 -7.138   1    27.818  ? 150  PHE A CE2   1 ? 
ATOM   1268  C  CZ    . PHE A 1 150 ? -8.16   -11.947 -6.998   1    25.184  ? 150  PHE A CZ    1 ? 
ATOM   1269  N  N     . VAL A 1 151 ? -4.956  -8.695  -3.826   1    20.473  ? 151  VAL A N     1 ? 
ATOM   1270  C  CA    . VAL A 1 151 ? -3.638  -8.775  -4.434   1    21.227  ? 151  VAL A CA    1 ? 
ATOM   1271  C  C     . VAL A 1 151 ? -2.669  -9.495  -3.492   1    18.907  ? 151  VAL A C     1 ? 
ATOM   1272  O  O     . VAL A 1 151 ? -1.964  -10.408 -3.901   1    22.257  ? 151  VAL A O     1 ? 
ATOM   1273  C  CB    . VAL A 1 151 ? -3.143  -7.386  -4.903   1    19.906  ? 151  VAL A CB    1 ? 
ATOM   1274  C  CG1   . VAL A 1 151 ? -1.688  -7.365  -5.367   1    22.064  ? 151  VAL A CG1   1 ? 
ATOM   1275  C  CG2   . VAL A 1 151 ? -4.007  -6.925  -6.065   1    21.101  ? 151  VAL A CG2   1 ? 
ATOM   1276  N  N     . ASN A 1 152 ? -2.63   -9.055  -2.244   1    20.134  ? 152  ASN A N     1 ? 
ATOM   1277  C  CA    . ASN A 1 152 ? -1.714  -9.614  -1.258   1    22.617  ? 152  ASN A CA    1 ? 
ATOM   1278  C  C     . ASN A 1 152 ? -2.031  -11.09  -1.012   1    22.749  ? 152  ASN A C     1 ? 
ATOM   1279  O  O     . ASN A 1 152 ? -1.09   -11.877 -0.824   1    18.147  ? 152  ASN A O     1 ? 
ATOM   1280  C  CB    . ASN A 1 152 ? -1.72   -8.804  0.039    1    19.837  ? 152  ASN A CB    1 ? 
ATOM   1281  C  CG    . ASN A 1 152 ? -0.805  -7.605  -0.096   1    24.694  ? 152  ASN A CG    1 ? 
ATOM   1282  O  OD1   . ASN A 1 152 ? 0.408   -7.712  0.151    1    25.425  ? 152  ASN A OD1   1 ? 
ATOM   1283  N  ND2   . ASN A 1 152 ? -1.362  -6.458  -0.464   1    19.772  ? 152  ASN A ND2   1 ? 
ATOM   1284  N  N     . MET A 1 153 ? -3.335  -11.427 -0.979   1    20.063  ? 153  MET A N     1 ? 
ATOM   1285  C  CA    A MET A 1 153 ? -3.787  -12.79  -0.728   0.5  22.236  ? 153  MET A CA    1 ? 
ATOM   1286  C  CA    B MET A 1 153 ? -3.749  -12.798 -0.707   0.5  22.543  ? 153  MET A CA    1 ? 
ATOM   1287  C  C     . MET A 1 153 ? -3.32   -13.687 -1.872   1    21.678  ? 153  MET A C     1 ? 
ATOM   1288  O  O     . MET A 1 153 ? -2.751  -14.749 -1.647   1    22.953  ? 153  MET A O     1 ? 
ATOM   1289  C  CB    A MET A 1 153 ? -5.311  -12.865 -0.572   0.5  23.229  ? 153  MET A CB    1 ? 
ATOM   1290  C  CB    B MET A 1 153 ? -5.239  -12.93  -0.352   0.5  23.974  ? 153  MET A CB    1 ? 
ATOM   1291  C  CG    A MET A 1 153 ? -5.861  -14.281 -0.384   0.5  23.267  ? 153  MET A CG    1 ? 
ATOM   1292  C  CG    B MET A 1 153 ? -5.751  -14.377 -0.198   0.5  25.039  ? 153  MET A CG    1 ? 
ATOM   1293  S  SD    A MET A 1 153 ? -5.139  -14.987 1.105    0.5  26.1    ? 153  MET A SD    1 ? 
ATOM   1294  S  SD    B MET A 1 153 ? -6.103  -15.242 -1.743   0.5  31.109  ? 153  MET A SD    1 ? 
ATOM   1295  C  CE    A MET A 1 153 ? -6.2    -14.466 2.467    0.5  25.618  ? 153  MET A CE    1 ? 
ATOM   1296  C  CE    B MET A 1 153 ? -7.581  -14.418 -2.358   0.5  31.308  ? 153  MET A CE    1 ? 
ATOM   1297  N  N     . LYS A 1 154 ? -3.55   -13.225 -3.101   1    20.021  ? 154  LYS A N     1 ? 
ATOM   1298  C  CA    . LYS A 1 154 ? -3.176  -13.999 -4.271   1    19.243  ? 154  LYS A CA    1 ? 
ATOM   1299  C  C     . LYS A 1 154 ? -1.663  -14.214 -4.289   1    20.958  ? 154  LYS A C     1 ? 
ATOM   1300  O  O     . LYS A 1 154 ? -1.205  -15.326 -4.544   1    21.768  ? 154  LYS A O     1 ? 
ATOM   1301  C  CB    . LYS A 1 154 ? -3.676  -13.387 -5.586   1    18.264  ? 154  LYS A CB    1 ? 
ATOM   1302  C  CG    . LYS A 1 154 ? -5.219  -13.536 -5.742   1    24.131  ? 154  LYS A CG    1 ? 
ATOM   1303  C  CD    . LYS A 1 154 ? -5.812  -14.94  -5.551   1    24.682  ? 154  LYS A CD    1 ? 
ATOM   1304  C  CE    . LYS A 1 154 ? -5.324  -15.94  -6.544   1    29.886  ? 154  LYS A CE    1 ? 
ATOM   1305  N  NZ    . LYS A 1 154 ? -5.953  -17.241 -6.27    1    31.185  ? 154  LYS A NZ    1 ? 
ATOM   1306  N  N     . ILE A 1 155 ? -0.918  -13.111 -4.128   1    20.695  ? 155  ILE A N     1 ? 
ATOM   1307  C  CA    . ILE A 1 155 ? 0.531   -13.164 -4.19    1    21.93   ? 155  ILE A CA    1 ? 
ATOM   1308  C  C     . ILE A 1 155 ? 1.002   -14.177 -3.152   1    19.919  ? 155  ILE A C     1 ? 
ATOM   1309  O  O     . ILE A 1 155 ? 1.956   -14.895 -3.399   1    24.468  ? 155  ILE A O     1 ? 
ATOM   1310  C  CB    . ILE A 1 155 ? 1.191   -11.776 -4.005   1    20.39   ? 155  ILE A CB    1 ? 
ATOM   1311  C  CG1   . ILE A 1 155 ? 1.078   -10.9   -5.311   1    21.485  ? 155  ILE A CG1   1 ? 
ATOM   1312  C  CG2   . ILE A 1 155 ? 2.661   -11.962 -3.6     1    21.485  ? 155  ILE A CG2   1 ? 
ATOM   1313  C  CD1   . ILE A 1 155 ? 1.339   -9.398  -5.15    1    16.253  ? 155  ILE A CD1   1 ? 
ATOM   1314  N  N     . SER A 1 156 ? 0.351   -14.202 -1.989   1    21.431  ? 156  SER A N     1 ? 
ATOM   1315  C  CA    . SER A 1 156 ? 0.847   -14.985 -0.874   1    19.937  ? 156  SER A CA    1 ? 
ATOM   1316  C  C     . SER A 1 156 ? 0.498   -16.484 -0.997   1    23.718  ? 156  SER A C     1 ? 
ATOM   1317  O  O     . SER A 1 156 ? 1.03    -17.303 -0.22    1    23.963  ? 156  SER A O     1 ? 
ATOM   1318  C  CB    . SER A 1 156 ? 0.392   -14.455 0.474    1    18.161  ? 156  SER A CB    1 ? 
ATOM   1319  O  OG    . SER A 1 156 ? 0.853   -13.13  0.718    1    21.312  ? 156  SER A OG    1 ? 
ATOM   1320  N  N     . THR A 1 157 ? -0.428  -16.844 -1.896   1    23.857  ? 157  THR A N     1 ? 
ATOM   1321  C  CA    . THR A 1 157 ? -1.022  -18.173 -1.847   1    25.418  ? 157  THR A CA    1 ? 
ATOM   1322  C  C     . THR A 1 157 ? -1.024  -18.886 -3.184   1    27.459  ? 157  THR A C     1 ? 
ATOM   1323  O  O     . THR A 1 157 ? -1.273  -20.088 -3.182   1    32.667  ? 157  THR A O     1 ? 
ATOM   1324  C  CB    . THR A 1 157 ? -2.441  -18.181 -1.273   1    27.422  ? 157  THR A CB    1 ? 
ATOM   1325  O  OG1   . THR A 1 157 ? -3.225  -17.295 -2.085   1    26.731  ? 157  THR A OG1   1 ? 
ATOM   1326  C  CG2   . THR A 1 157 ? -2.45   -17.82  0.201    1    25.578  ? 157  THR A CG2   1 ? 
ATOM   1327  N  N     . ASP A 1 158 ? -0.945  -18.149 -4.3     1    28.502  ? 158  ASP A N     1 ? 
ATOM   1328  C  CA    . ASP A 1 158 ? -1.169  -18.752 -5.606   1    26.96   ? 158  ASP A CA    1 ? 
ATOM   1329  C  C     . ASP A 1 158 ? 0.126   -18.634 -6.4     1    25.436  ? 158  ASP A C     1 ? 
ATOM   1330  O  O     . ASP A 1 158 ? 0.519   -17.525 -6.769   1    26.376  ? 158  ASP A O     1 ? 
ATOM   1331  C  CB    . ASP A 1 158 ? -2.323  -18.083 -6.369   1    24.899  ? 158  ASP A CB    1 ? 
ATOM   1332  C  CG    . ASP A 1 158 ? -2.792  -18.778 -7.65    1    31.329  ? 158  ASP A CG    1 ? 
ATOM   1333  O  OD1   . ASP A 1 158 ? -1.92   -19.321 -8.391   1    29.433  ? 158  ASP A OD1   1 ? 
ATOM   1334  O  OD2   . ASP A 1 158 ? -4.03   -18.716 -7.977   1    26.328  ? 158  ASP A OD2   1 ? 
ATOM   1335  N  N     . LYS A 1 159 ? 0.741   -19.779 -6.746   1    26.157  ? 159  LYS A N     1 ? 
ATOM   1336  C  CA    . LYS A 1 159 ? 1.993   -19.805 -7.508   1    27.642  ? 159  LYS A CA    1 ? 
ATOM   1337  C  C     . LYS A 1 159 ? 1.893   -19.074 -8.845   1    27.219  ? 159  LYS A C     1 ? 
ATOM   1338  O  O     . LYS A 1 159 ? 2.903   -18.581 -9.346   1    23.771  ? 159  LYS A O     1 ? 
ATOM   1339  C  CB    . LYS A 1 159 ? 2.512   -21.228 -7.804   1    36.084  ? 159  LYS A CB    1 ? 
ATOM   1340  C  CG    . LYS A 1 159 ? 2.689   -22.076 -6.556   1    44.3    ? 159  LYS A CG    1 ? 
ATOM   1341  C  CD    . LYS A 1 159 ? 2.972   -23.551 -6.827   1    57.288  ? 159  LYS A CD    1 ? 
ATOM   1342  C  CE    . LYS A 1 159 ? 4.369   -23.907 -6.45    1    63.307  ? 159  LYS A CE    1 ? 
ATOM   1343  N  NZ    . LYS A 1 159 ? 4.455   -23.996 -4.988   1    69.737  ? 159  LYS A NZ    1 ? 
ATOM   1344  N  N     . SER A 1 160 ? 0.704   -18.973 -9.462   1    26.093  ? 160  SER A N     1 ? 
ATOM   1345  C  CA    . SER A 1 160 ? 0.742   -18.272 -10.749  1    29.863  ? 160  SER A CA    1 ? 
ATOM   1346  C  C     . SER A 1 160 ? 0.816   -16.754 -10.559  1    25.824  ? 160  SER A C     1 ? 
ATOM   1347  O  O     . SER A 1 160 ? 1.118   -15.992 -11.501  1    24.39   ? 160  SER A O     1 ? 
ATOM   1348  C  CB    . SER A 1 160 ? -0.399  -18.686 -11.667  1    37.428  ? 160  SER A CB    1 ? 
ATOM   1349  O  OG    . SER A 1 160 ? -1.596  -18.569 -10.93   1    47.986  ? 160  SER A OG    1 ? 
ATOM   1350  N  N     . TRP A 1 161 ? 0.577   -16.302 -9.32    1    21.71   ? 161  TRP A N     1 ? 
ATOM   1351  C  CA    . TRP A 1 161 ? 0.755   -14.885 -9.044   1    20.897  ? 161  TRP A CA    1 ? 
ATOM   1352  C  C     . TRP A 1 161 ? 2.162   -14.589 -8.51    1    23.47   ? 161  TRP A C     1 ? 
ATOM   1353  O  O     . TRP A 1 161 ? 2.419   -13.468 -8.075   1    25.767  ? 161  TRP A O     1 ? 
ATOM   1354  C  CB    . TRP A 1 161 ? -0.276  -14.435 -8.015   1    18.448  ? 161  TRP A CB    1 ? 
ATOM   1355  C  CG    . TRP A 1 161 ? -1.685  -14.323 -8.551   1    22.923  ? 161  TRP A CG    1 ? 
ATOM   1356  C  CD1   . TRP A 1 161 ? -2.526  -15.326 -8.922   1    22.274  ? 161  TRP A CD1   1 ? 
ATOM   1357  C  CD2   . TRP A 1 161 ? -2.412  -13.096 -8.754   1    21.572  ? 161  TRP A CD2   1 ? 
ATOM   1358  N  NE1   . TRP A 1 161 ? -3.738  -14.813 -9.332   1    23.595  ? 161  TRP A NE1   1 ? 
ATOM   1359  C  CE2   . TRP A 1 161 ? -3.694  -13.45  -9.23    1    22.768  ? 161  TRP A CE2   1 ? 
ATOM   1360  C  CE3   . TRP A 1 161 ? -2.109  -11.742 -8.544   1    20.94   ? 161  TRP A CE3   1 ? 
ATOM   1361  C  CZ2   . TRP A 1 161 ? -4.653  -12.492 -9.527   1    19.998  ? 161  TRP A CZ2   1 ? 
ATOM   1362  C  CZ3   . TRP A 1 161 ? -3.077  -10.802 -8.797   1    21.939  ? 161  TRP A CZ3   1 ? 
ATOM   1363  C  CH2   . TRP A 1 161 ? -4.321  -11.177 -9.31    1    21.584  ? 161  TRP A CH2   1 ? 
ATOM   1364  N  N     . GLN A 1 162 ? 3.041   -15.593 -8.504   1    20.35   ? 162  GLN A N     1 ? 
ATOM   1365  C  CA    . GLN A 1 162 ? 4.364   -15.457 -7.898   1    21.991  ? 162  GLN A CA    1 ? 
ATOM   1366  C  C     . GLN A 1 162 ? 5.352   -15.355 -9.041   1    24.814  ? 162  GLN A C     1 ? 
ATOM   1367  O  O     . GLN A 1 162 ? 5.241   -16.1   -10.001  1    28.27   ? 162  GLN A O     1 ? 
ATOM   1368  C  CB    . GLN A 1 162 ? 4.619   -16.66  -6.989   1    19.395  ? 162  GLN A CB    1 ? 
ATOM   1369  C  CG    . GLN A 1 162 ? 3.771   -16.559 -5.736   1    23.13   ? 162  GLN A CG    1 ? 
ATOM   1370  C  CD    . GLN A 1 162 ? 3.787   -17.757 -4.816   1    25.853  ? 162  GLN A CD    1 ? 
ATOM   1371  O  OE1   . GLN A 1 162 ? 4.406   -18.777 -5.091   1    26.496  ? 162  GLN A OE1   1 ? 
ATOM   1372  N  NE2   . GLN A 1 162 ? 3.066   -17.66  -3.708   1    26.567  ? 162  GLN A NE2   1 ? 
ATOM   1373  N  N     . GLY A 1 163 ? 6.307   -14.43  -8.972   1    29.941  ? 163  GLY A N     1 ? 
ATOM   1374  C  CA    . GLY A 1 163 ? 7.228   -14.288 -10.1    1    31.046  ? 163  GLY A CA    1 ? 
ATOM   1375  C  C     . GLY A 1 163 ? 6.657   -13.42  -11.227  1    31.903  ? 163  GLY A C     1 ? 
ATOM   1376  O  O     . GLY A 1 163 ? 7.17    -13.456 -12.33   1    31.653  ? 163  GLY A O     1 ? 
ATOM   1377  N  N     . VAL A 1 164 ? 5.566   -12.687 -10.953  1    27.693  ? 164  VAL A N     1 ? 
ATOM   1378  C  CA    . VAL A 1 164 ? 5.008   -11.695 -11.858  1    27.491  ? 164  VAL A CA    1 ? 
ATOM   1379  C  C     . VAL A 1 164 ? 4.939   -10.382 -11.099  1    25.894  ? 164  VAL A C     1 ? 
ATOM   1380  O  O     . VAL A 1 164 ? 4.66    -10.382 -9.905   1    27.494  ? 164  VAL A O     1 ? 
ATOM   1381  C  CB    . VAL A 1 164 ? 3.581   -12.169 -12.172  1    30.711  ? 164  VAL A CB    1 ? 
ATOM   1382  C  CG1   . VAL A 1 164 ? 2.824   -11.161 -13.027  1    28.759  ? 164  VAL A CG1   1 ? 
ATOM   1383  C  CG2   . VAL A 1 164 ? 3.614   -13.546 -12.84   1    35.669  ? 164  VAL A CG2   1 ? 
ATOM   1384  N  N     . THR A 1 165 ? 5.209   -9.275  -11.783  1    22.352  ? 165  THR A N     1 ? 
ATOM   1385  C  CA    . THR A 1 165 ? 5.065   -7.981  -11.132  1    22.49   ? 165  THR A CA    1 ? 
ATOM   1386  C  C     . THR A 1 165 ? 3.6     -7.536  -11.234  1    22.749  ? 165  THR A C     1 ? 
ATOM   1387  O  O     . THR A 1 165 ? 3.085   -7.443  -12.344  1    20.838  ? 165  THR A O     1 ? 
ATOM   1388  C  CB    . THR A 1 165 ? 5.984   -6.98   -11.833  1    24.002  ? 165  THR A CB    1 ? 
ATOM   1389  O  OG1   . THR A 1 165 ? 7.28    -7.572  -11.878  1    21.946  ? 165  THR A OG1   1 ? 
ATOM   1390  C  CG2   . THR A 1 165 ? 5.995   -5.623  -11.143  1    21.97   ? 165  THR A CG2   1 ? 
ATOM   1391  N  N     . ILE A 1 166 ? 2.936   -7.29   -10.092  1    20.896  ? 166  ILE A N     1 ? 
ATOM   1392  C  CA    . ILE A 1 166 ? 1.554   -6.82   -10.112  1    21.607  ? 166  ILE A CA    1 ? 
ATOM   1393  C  C     . ILE A 1 166 ? 1.562   -5.315  -9.861   1    23.573  ? 166  ILE A C     1 ? 
ATOM   1394  O  O     . ILE A 1 166 ? 2.155   -4.846  -8.884   1    23.924  ? 166  ILE A O     1 ? 
ATOM   1395  C  CB    . ILE A 1 166 ? 0.717   -7.506  -9.011   1    22.434  ? 166  ILE A CB    1 ? 
ATOM   1396  C  CG1   . ILE A 1 166 ? 0.942   -9.04   -8.997   1    24.039  ? 166  ILE A CG1   1 ? 
ATOM   1397  C  CG2   . ILE A 1 166 ? -0.783  -7.173  -9.148   1    19.81   ? 166  ILE A CG2   1 ? 
ATOM   1398  C  CD1   . ILE A 1 166 ? 0.597   -9.661  -10.337  1    24.181  ? 166  ILE A CD1   1 ? 
ATOM   1399  N  N     . TYR A 1 167 ? 0.905   -4.56   -10.737  1    18.952  ? 167  TYR A N     1 ? 
ATOM   1400  C  CA    . TYR A 1 167 ? 0.687   -3.16   -10.434  1    19.71   ? 167  TYR A CA    1 ? 
ATOM   1401  C  C     . TYR A 1 167 ? -0.793  -2.989  -10.121  1    22.3    ? 167  TYR A C     1 ? 
ATOM   1402  O  O     . TYR A 1 167 ? -1.612  -3.522  -10.864  1    18.089  ? 167  TYR A O     1 ? 
ATOM   1403  C  CB    . TYR A 1 167 ? 1.012   -2.242  -11.612  1    20.322  ? 167  TYR A CB    1 ? 
ATOM   1404  C  CG    . TYR A 1 167 ? 2.484   -2.271  -12.013  1    23.379  ? 167  TYR A CG    1 ? 
ATOM   1405  C  CD1   . TYR A 1 167 ? 2.987   -3.295  -12.812  1    21.813  ? 167  TYR A CD1   1 ? 
ATOM   1406  C  CD2   . TYR A 1 167 ? 3.361   -1.295  -11.561  1    20.342  ? 167  TYR A CD2   1 ? 
ATOM   1407  C  CE1   . TYR A 1 167 ? 4.318   -3.312  -13.204  1    23.255  ? 167  TYR A CE1   1 ? 
ATOM   1408  C  CE2   . TYR A 1 167 ? 4.689   -1.287  -11.961  1    22.873  ? 167  TYR A CE2   1 ? 
ATOM   1409  C  CZ    . TYR A 1 167 ? 5.163   -2.3    -12.776  1    25.491  ? 167  TYR A CZ    1 ? 
ATOM   1410  O  OH    . TYR A 1 167 ? 6.474   -2.303  -13.16   1    26.561  ? 167  TYR A OH    1 ? 
ATOM   1411  N  N     . PHE A 1 168 ? -1.085  -2.193  -9.079   1    19.672  ? 168  PHE A N     1 ? 
ATOM   1412  C  CA    . PHE A 1 168 ? -2.449  -1.752  -8.799   1    18.442  ? 168  PHE A CA    1 ? 
ATOM   1413  C  C     . PHE A 1 168 ? -2.483  -0.227  -8.662   1    16.538  ? 168  PHE A C     1 ? 
ATOM   1414  O  O     . PHE A 1 168 ? -1.958  0.337   -7.702   1    15.894  ? 168  PHE A O     1 ? 
ATOM   1415  C  CB    . PHE A 1 168 ? -2.968  -2.449  -7.547   1    16.072  ? 168  PHE A CB    1 ? 
ATOM   1416  C  CG    . PHE A 1 168 ? -4.355  -1.991  -7.16    1    17.921  ? 168  PHE A CG    1 ? 
ATOM   1417  C  CD1   . PHE A 1 168 ? -5.368  -1.878  -8.118   1    18.03   ? 168  PHE A CD1   1 ? 
ATOM   1418  C  CD2   . PHE A 1 168 ? -4.637  -1.685  -5.831   1    16.954  ? 168  PHE A CD2   1 ? 
ATOM   1419  C  CE1   . PHE A 1 168 ? -6.653  -1.498  -7.732   1    19.307  ? 168  PHE A CE1   1 ? 
ATOM   1420  C  CE2   . PHE A 1 168 ? -5.935  -1.303  -5.455   1    21.322  ? 168  PHE A CE2   1 ? 
ATOM   1421  C  CZ    . PHE A 1 168 ? -6.922  -1.173  -6.412   1    17.167  ? 168  PHE A CZ    1 ? 
ATOM   1422  N  N     . SER A 1 169 ? -3.117  0.404   -9.657   1    17.688  ? 169  SER A N     1 ? 
ATOM   1423  C  CA    . SER A 1 169 ? -3.396  1.836   -9.707   1    16.951  ? 169  SER A CA    1 ? 
ATOM   1424  C  C     . SER A 1 169 ? -4.898  2.072   -9.471   1    18.815  ? 169  SER A C     1 ? 
ATOM   1425  O  O     . SER A 1 169 ? -5.729  1.944   -10.394  1    15.571  ? 169  SER A O     1 ? 
ATOM   1426  C  CB    . SER A 1 169 ? -2.987  2.317   -11.047  1    16.277  ? 169  SER A CB    1 ? 
ATOM   1427  O  OG    . SER A 1 169 ? -3.108  3.731   -11.13   1    17.962  ? 169  SER A OG    1 ? 
ATOM   1428  N  N     . GLY A 1 170 ? -5.249  2.382   -8.224   1    16.561  ? 170  GLY A N     1 ? 
ATOM   1429  C  CA    . GLY A 1 170 ? -6.647  2.452   -7.81    1    17.121  ? 170  GLY A CA    1 ? 
ATOM   1430  C  C     . GLY A 1 170 ? -7.262  3.845   -7.94    1    17.626  ? 170  GLY A C     1 ? 
ATOM   1431  O  O     . GLY A 1 170 ? -6.695  4.742   -8.57    1    14.969  ? 170  GLY A O     1 ? 
ATOM   1432  N  N     . HIS A 1 171 ? -8.428  4.016   -7.299   1    18.141  ? 171  HIS A N     1 ? 
ATOM   1433  C  CA    . HIS A 1 171 ? -9.283  5.165   -7.539   1    18.41   ? 171  HIS A CA    1 ? 
ATOM   1434  C  C     . HIS A 1 171 ? -8.667  6.459   -7.007   1    18.668  ? 171  HIS A C     1 ? 
ATOM   1435  O  O     . HIS A 1 171 ? -9.128  7.551   -7.358   1    18.309  ? 171  HIS A O     1 ? 
ATOM   1436  C  CB    . HIS A 1 171 ? -10.678 4.995   -6.907   1    15.261  ? 171  HIS A CB    1 ? 
ATOM   1437  C  CG    . HIS A 1 171 ? -10.649 5.126   -5.426   1    15.887  ? 171  HIS A CG    1 ? 
ATOM   1438  N  ND1   . HIS A 1 171 ? -11.482 5.955   -4.692   1    14.133  ? 171  HIS A ND1   1 ? 
ATOM   1439  C  CD2   . HIS A 1 171 ? -9.881  4.447   -4.535   1    16.353  ? 171  HIS A CD2   1 ? 
ATOM   1440  C  CE1   . HIS A 1 171 ? -11.22  5.77    -3.397   1    16.011  ? 171  HIS A CE1   1 ? 
ATOM   1441  N  NE2   . HIS A 1 171 ? -10.226 4.864   -3.28    1    15.621  ? 171  HIS A NE2   1 ? 
ATOM   1442  N  N     . GLU A 1 172 ? -7.617  6.372   -6.183   1    17.781  ? 172  GLU A N     1 ? 
ATOM   1443  C  CA    . GLU A 1 172 ? -7.052  7.612   -5.659   1    17.391  ? 172  GLU A CA    1 ? 
ATOM   1444  C  C     . GLU A 1 172 ? -5.866  8.103   -6.514   1    16.48   ? 172  GLU A C     1 ? 
ATOM   1445  O  O     . GLU A 1 172 ? -5.311  9.15    -6.222   1    14.052  ? 172  GLU A O     1 ? 
ATOM   1446  C  CB    . GLU A 1 172 ? -6.584  7.529   -4.199   1    21.166  ? 172  GLU A CB    1 ? 
ATOM   1447  C  CG    . GLU A 1 172 ? -7.613  6.883   -3.274   1    24.253  ? 172  GLU A CG    1 ? 
ATOM   1448  C  CD    . GLU A 1 172 ? -7.225  6.859   -1.804   1    29.153  ? 172  GLU A CD    1 ? 
ATOM   1449  O  OE1   . GLU A 1 172 ? -6.129  6.366   -1.451   1    31.614  ? 172  GLU A OE1   1 ? 
ATOM   1450  O  OE2   . GLU A 1 172 ? -8.075  7.263   -0.994   1    28.342  ? 172  GLU A OE2   1 ? 
ATOM   1451  N  N     . THR A 1 173 ? -5.526  7.39    -7.58    1    14.53   ? 173  THR A N     1 ? 
ATOM   1452  C  CA    . THR A 1 173 ? -4.486  7.769   -8.514   1    16.078  ? 173  THR A CA    1 ? 
ATOM   1453  C  C     . THR A 1 173 ? -5.122  8.386   -9.753   1    16.065  ? 173  THR A C     1 ? 
ATOM   1454  O  O     . THR A 1 173 ? -5.822  7.696   -10.491  1    16.509  ? 173  THR A O     1 ? 
ATOM   1455  C  CB    . THR A 1 173 ? -3.666  6.526   -8.88    1    17.668  ? 173  THR A CB    1 ? 
ATOM   1456  O  OG1   . THR A 1 173 ? -3.339  5.814   -7.685   1    17.147  ? 173  THR A OG1   1 ? 
ATOM   1457  C  CG2   . THR A 1 173 ? -2.4    6.91    -9.623   1    16.256  ? 173  THR A CG2   1 ? 
ATOM   1458  N  N     . PRO A 1 174 ? -4.953  9.709   -10.006  1    16.179  ? 174  PRO A N     1 ? 
ATOM   1459  C  CA    . PRO A 1 174 ? -5.702  10.38   -11.059  1    17.11   ? 174  PRO A CA    1 ? 
ATOM   1460  C  C     . PRO A 1 174 ? -5.45   9.763   -12.416  1    17.821  ? 174  PRO A C     1 ? 
ATOM   1461  O  O     . PRO A 1 174 ? -4.318  9.369   -12.717  1    16.84   ? 174  PRO A O     1 ? 
ATOM   1462  C  CB    . PRO A 1 174 ? -5.169  11.843  -11.009  1    16.193  ? 174  PRO A CB    1 ? 
ATOM   1463  C  CG    . PRO A 1 174 ? -4.862  11.998  -9.536   1    15.814  ? 174  PRO A CG    1 ? 
ATOM   1464  C  CD    . PRO A 1 174 ? -4.138  10.652  -9.226   1    16.589  ? 174  PRO A CD    1 ? 
ATOM   1465  N  N     . GLY A 1 175 ? -6.513  9.768   -13.226  1    17.15   ? 175  GLY A N     1 ? 
ATOM   1466  C  CA    . GLY A 1 175 ? -6.478  9.306   -14.606  1    17.06   ? 175  GLY A CA    1 ? 
ATOM   1467  C  C     . GLY A 1 175 ? -7.533  8.202   -14.774  1    20.004  ? 175  GLY A C     1 ? 
ATOM   1468  O  O     . GLY A 1 175 ? -7.68   7.358   -13.893  1    19.067  ? 175  GLY A O     1 ? 
ATOM   1469  N  N     . GLU A 1 176 ? -8.214  8.182   -15.927  1    18.951  ? 176  GLU A N     1 ? 
ATOM   1470  C  CA    . GLU A 1 176 ? -8.905  6.997   -16.391  1    19.575  ? 176  GLU A CA    1 ? 
ATOM   1471  C  C     . GLU A 1 176 ? -7.935  5.811   -16.419  1    22.731  ? 176  GLU A C     1 ? 
ATOM   1472  O  O     . GLU A 1 176 ? -6.782  5.954   -16.831  1    19.243  ? 176  GLU A O     1 ? 
ATOM   1473  C  CB    . GLU A 1 176 ? -9.387  7.271   -17.818  1    20.529  ? 176  GLU A CB    1 ? 
ATOM   1474  C  CG    . GLU A 1 176 ? -10.488 8.335   -17.964  1    27.128  ? 176  GLU A CG    1 ? 
ATOM   1475  C  CD    . GLU A 1 176 ? -11.108 8.075   -19.359  1    35.785  ? 176  GLU A CD    1 ? 
ATOM   1476  O  OE1   . GLU A 1 176 ? -12.009 7.166   -19.6    1    40.66   ? 176  GLU A OE1   1 ? 
ATOM   1477  O  OE2   . GLU A 1 176 ? -10.505 8.74    -20.263  1    35.637  ? 176  GLU A OE2   1 ? 
ATOM   1478  N  N     . GLY A 1 177 ? -8.465  4.618   -16.082  1    17.505  ? 177  GLY A N     1 ? 
ATOM   1479  C  CA    . GLY A 1 177 ? -7.716  3.387   -16.031  1    19.922  ? 177  GLY A CA    1 ? 
ATOM   1480  C  C     . GLY A 1 177 ? -6.92   3.141   -17.319  1    25.403  ? 177  GLY A C     1 ? 
ATOM   1481  O  O     . GLY A 1 177 ? -5.713  2.87    -17.289  1    22.78   ? 177  GLY A O     1 ? 
ATOM   1482  N  N     . GLU A 1 178 ? -7.583  3.302   -18.462  1    22.771  ? 178  GLU A N     1 ? 
ATOM   1483  C  CA    . GLU A 1 178 ? -6.936  2.962   -19.725  1    29.083  ? 178  GLU A CA    1 ? 
ATOM   1484  C  C     . GLU A 1 178 ? -5.751  3.889   -19.994  1    25.654  ? 178  GLU A C     1 ? 
ATOM   1485  O  O     . GLU A 1 178 ? -4.748  3.478   -20.592  1    24.581  ? 178  GLU A O     1 ? 
ATOM   1486  C  CB    . GLU A 1 178 ? -7.912  3.08    -20.897  1    33.159  ? 178  GLU A CB    1 ? 
ATOM   1487  C  CG    . GLU A 1 178 ? -9.303  2.571   -20.541  1    51.385  ? 178  GLU A CG    1 ? 
ATOM   1488  C  CD    . GLU A 1 178 ? -10.295 3.647   -20.142  1    52.12   ? 178  GLU A CD    1 ? 
ATOM   1489  O  OE1   . GLU A 1 178 ? -10.638 3.928   -18.952  1    45.31   ? 178  GLU A OE1   1 ? 
ATOM   1490  O  OE2   . GLU A 1 178 ? -10.77  4.212   -21.15   1    70.599  ? 178  GLU A OE2   1 ? 
ATOM   1491  N  N     . HIS A 1 179 ? -5.867  5.148   -19.572  1    23.073  ? 179  HIS A N     1 ? 
ATOM   1492  C  CA    . HIS A 1 179 ? -4.781  6.088   -19.802  1    22.875  ? 179  HIS A CA    1 ? 
ATOM   1493  C  C     . HIS A 1 179 ? -3.662  5.985   -18.766  1    24.085  ? 179  HIS A C     1 ? 
ATOM   1494  O  O     . HIS A 1 179 ? -2.523  6.377   -19.052  1    21.209  ? 179  HIS A O     1 ? 
ATOM   1495  C  CB    . HIS A 1 179 ? -5.304  7.516   -19.894  1    27.346  ? 179  HIS A CB    1 ? 
ATOM   1496  C  CG    . HIS A 1 179 ? -6.109  7.602   -21.158  1    36.516  ? 179  HIS A CG    1 ? 
ATOM   1497  N  ND1   . HIS A 1 179 ? -5.549  7.805   -22.407  1    38.305  ? 179  HIS A ND1   1 ? 
ATOM   1498  C  CD2   . HIS A 1 179 ? -7.434  7.376   -21.372  1    36.218  ? 179  HIS A CD2   1 ? 
ATOM   1499  C  CE1   . HIS A 1 179 ? -6.519  7.771   -23.326  1    36.103  ? 179  HIS A CE1   1 ? 
ATOM   1500  N  NE2   . HIS A 1 179 ? -7.66   7.482   -22.72   1    34.775  ? 179  HIS A NE2   1 ? 
ATOM   1501  N  N     . LYS A 1 180 ? -3.993  5.514   -17.556  1    18.341  ? 180  LYS A N     1 ? 
ATOM   1502  C  CA    . LYS A 1 180 ? -2.924  5.127   -16.645  1    19.731  ? 180  LYS A CA    1 ? 
ATOM   1503  C  C     . LYS A 1 180 ? -2.203  3.889   -17.207  1    20.189  ? 180  LYS A C     1 ? 
ATOM   1504  O  O     . LYS A 1 180 ? -0.986  3.767   -17.103  1    18.443  ? 180  LYS A O     1 ? 
ATOM   1505  C  CB    . LYS A 1 180 ? -3.467  4.889   -15.232  1    16.952  ? 180  LYS A CB    1 ? 
ATOM   1506  C  CG    . LYS A 1 180 ? -4.191  6.097   -14.65   1    17.415  ? 180  LYS A CG    1 ? 
ATOM   1507  C  CD    . LYS A 1 180 ? -4.511  6.016   -13.148  1    19.482  ? 180  LYS A CD    1 ? 
ATOM   1508  C  CE    . LYS A 1 180 ? -5.641  5.047   -12.812  1    17.878  ? 180  LYS A CE    1 ? 
ATOM   1509  N  NZ    . LYS A 1 180 ? -5.903  4.983   -11.362  1    18.865  ? 180  LYS A NZ    1 ? 
ATOM   1510  N  N     . ILE A 1 181 ? -2.938  2.956   -17.797  1    19.379  ? 181  ILE A N     1 ? 
ATOM   1511  C  CA    . ILE A 1 181 ? -2.305  1.826   -18.49   1    20.367  ? 181  ILE A CA    1 ? 
ATOM   1512  C  C     . ILE A 1 181 ? -1.383  2.303   -19.619  1    23.986  ? 181  ILE A C     1 ? 
ATOM   1513  O  O     . ILE A 1 181 ? -0.246  1.815   -19.768  1    25.236  ? 181  ILE A O     1 ? 
ATOM   1514  C  CB    . ILE A 1 181 ? -3.347  0.812   -19.002  1    25.324  ? 181  ILE A CB    1 ? 
ATOM   1515  C  CG1   . ILE A 1 181 ? -3.814  -0.07   -17.851  1    23.196  ? 181  ILE A CG1   1 ? 
ATOM   1516  C  CG2   . ILE A 1 181 ? -2.82   -0.026  -20.188  1    24.119  ? 181  ILE A CG2   1 ? 
ATOM   1517  C  CD1   . ILE A 1 181 ? -5.194  -0.685  -18.035  1    21.772  ? 181  ILE A CD1   1 ? 
ATOM   1518  N  N     . MET A 1 182 ? -1.831  3.291   -20.388  1    23.021  ? 182  MET A N     1 ? 
ATOM   1519  C  CA    . MET A 1 182 ? -1.033  3.779   -21.515  1    26.824  ? 182  MET A CA    1 ? 
ATOM   1520  C  C     . MET A 1 182 ? 0.24    4.468   -21.011  1    27.632  ? 182  MET A C     1 ? 
ATOM   1521  O  O     . MET A 1 182 ? 1.31    4.308   -21.595  1    24.971  ? 182  MET A O     1 ? 
ATOM   1522  C  CB    . MET A 1 182 ? -1.843  4.762   -22.364  1    29.222  ? 182  MET A CB    1 ? 
ATOM   1523  C  CG    . MET A 1 182 ? -1.221  5.085   -23.7    1    37.328  ? 182  MET A CG    1 ? 
ATOM   1524  S  SD    . MET A 1 182 ? -1.06   3.705   -24.86   1    40.268  ? 182  MET A SD    1 ? 
ATOM   1525  C  CE    . MET A 1 182 ? -0.539  4.796   -26.191  1    33.91   ? 182  MET A CE    1 ? 
ATOM   1526  N  N     . GLU A 1 183 ? 0.134   5.232   -19.913  1    22.459  ? 183  GLU A N     1 ? 
ATOM   1527  C  CA    . GLU A 1 183 ? 1.301   5.871   -19.34   1    24.658  ? 183  GLU A CA    1 ? 
ATOM   1528  C  C     . GLU A 1 183 ? 2.342   4.809   -18.957  1    26.439  ? 183  GLU A C     1 ? 
ATOM   1529  O  O     . GLU A 1 183 ? 3.54    4.983   -19.172  1    23.183  ? 183  GLU A O     1 ? 
ATOM   1530  C  CB    . GLU A 1 183 ? 0.8     6.764   -18.207  1    26.273  ? 183  GLU A CB    1 ? 
ATOM   1531  C  CG    . GLU A 1 183 ? 1.927   7.258   -17.308  1    30.801  ? 183  GLU A CG    1 ? 
ATOM   1532  C  CD    . GLU A 1 183 ? 1.506   8.143   -16.143  1    41.66   ? 183  GLU A CD    1 ? 
ATOM   1533  O  OE1   . GLU A 1 183 ? 0.757   7.652   -15.238  1    45.482  ? 183  GLU A OE1   1 ? 
ATOM   1534  O  OE2   . GLU A 1 183 ? 1.902   9.352   -16.176  1    39.612  ? 183  GLU A OE2   1 ? 
ATOM   1535  N  N     . PHE A 1 184 ? 1.869   3.714   -18.366  1    24.458  ? 184  PHE A N     1 ? 
ATOM   1536  C  CA    . PHE A 1 184 ? 2.704   2.577   -18.033  1    22.989  ? 184  PHE A CA    1 ? 
ATOM   1537  C  C     . PHE A 1 184 ? 3.393   2.031   -19.278  1    25.086  ? 184  PHE A C     1 ? 
ATOM   1538  O  O     . PHE A 1 184 ? 4.61    1.869   -19.271  1    23.911  ? 184  PHE A O     1 ? 
ATOM   1539  C  CB    . PHE A 1 184 ? 1.946   1.514   -17.248  1    19.733  ? 184  PHE A CB    1 ? 
ATOM   1540  C  CG    . PHE A 1 184 ? 2.79    0.268   -17.018  1    21.495  ? 184  PHE A CG    1 ? 
ATOM   1541  C  CD1   . PHE A 1 184 ? 3.867   0.286   -16.119  1    21.419  ? 184  PHE A CD1   1 ? 
ATOM   1542  C  CD2   . PHE A 1 184 ? 2.56    -0.9    -17.741  1    21.015  ? 184  PHE A CD2   1 ? 
ATOM   1543  C  CE1   . PHE A 1 184 ? 4.69    -0.805  -15.949  1    20.989  ? 184  PHE A CE1   1 ? 
ATOM   1544  C  CE2   . PHE A 1 184 ? 3.403   -2.009  -17.575  1    23.56   ? 184  PHE A CE2   1 ? 
ATOM   1545  C  CZ    . PHE A 1 184 ? 4.424   -1.98   -16.634  1    22.239  ? 184  PHE A CZ    1 ? 
ATOM   1546  N  N     . ILE A 1 185 ? 2.62    1.705   -20.318  1    22.184  ? 185  ILE A N     1 ? 
ATOM   1547  C  CA    . ILE A 1 185 ? 3.161   1.196   -21.574  1    25.652  ? 185  ILE A CA    1 ? 
ATOM   1548  C  C     . ILE A 1 185 ? 4.265   2.117   -22.127  1    31.206  ? 185  ILE A C     1 ? 
ATOM   1549  O  O     . ILE A 1 185 ? 5.298   1.628   -22.58   1    30.055  ? 185  ILE A O     1 ? 
ATOM   1550  C  CB    . ILE A 1 185 ? 2.042   0.916   -22.596  1    27.424  ? 185  ILE A CB    1 ? 
ATOM   1551  C  CG1   . ILE A 1 185 ? 1.131   -0.233  -22.083  1    25.025  ? 185  ILE A CG1   1 ? 
ATOM   1552  C  CG2   . ILE A 1 185 ? 2.616   0.618   -23.993  1    28.571  ? 185  ILE A CG2   1 ? 
ATOM   1553  C  CD1   . ILE A 1 185 ? -0.192  -0.384  -22.829  1    26.088  ? 185  ILE A CD1   1 ? 
ATOM   1554  N  N     . ARG A 1 186 ? 4.066   3.435   -22.081  1    27.558  ? 186  ARG A N     1 ? 
ATOM   1555  C  CA    . ARG A 1 186 ? 5.052   4.37    -22.588  1    29.972  ? 186  ARG A CA    1 ? 
ATOM   1556  C  C     . ARG A 1 186 ? 6.302   4.331   -21.708  1    30.402  ? 186  ARG A C     1 ? 
ATOM   1557  O  O     . ARG A 1 186 ? 7.395   4.468   -22.226  1    29.422  ? 186  ARG A O     1 ? 
ATOM   1558  C  CB    . ARG A 1 186 ? 4.534   5.796   -22.814  1    30.158  ? 186  ARG A CB    1 ? 
ATOM   1559  C  CG    . ARG A 1 186 ? 3.672   5.999   -24.064  1    31.145  ? 186  ARG A CG    1 ? 
ATOM   1560  C  CD    . ARG A 1 186 ? 3.182   7.454   -24.283  1    37.563  ? 186  ARG A CD    1 ? 
ATOM   1561  N  NE    . ARG A 1 186 ? 2.639   8.092   -23.069  1    47.107  ? 186  ARG A NE    1 ? 
ATOM   1562  C  CZ    . ARG A 1 186 ? 1.35    8.332   -22.742  1    48.37   ? 186  ARG A CZ    1 ? 
ATOM   1563  N  NH1   . ARG A 1 186 ? 0.444   8.292   -23.707  1    44.367  ? 186  ARG A NH1   1 ? 
ATOM   1564  N  NH2   . ARG A 1 186 ? 0.986   8.639   -21.479  1    30.928  ? 186  ARG A NH2   1 ? 
ATOM   1565  N  N     . SER A 1 187 ? 6.154   4.122   -20.399  1    31.557  ? 187  SER A N     1 ? 
ATOM   1566  C  CA    . SER A 1 187 ? 7.305   4.118   -19.511  1    31.081  ? 187  SER A CA    1 ? 
ATOM   1567  C  C     . SER A 1 187 ? 8.102   2.854   -19.792  1    31.647  ? 187  SER A C     1 ? 
ATOM   1568  O  O     . SER A 1 187 ? 9.309   2.83    -19.604  1    36.671  ? 187  SER A O     1 ? 
ATOM   1569  C  CB    . SER A 1 187 ? 6.92    4.166   -18.066  1    27.927  ? 187  SER A CB    1 ? 
ATOM   1570  O  OG    . SER A 1 187 ? 6.577   2.862   -17.599  1    32.182  ? 187  SER A OG    1 ? 
ATOM   1571  N  N     . GLU A 1 188 ? 7.416   1.807   -20.232  1    27.736  ? 188  GLU A N     1 ? 
ATOM   1572  C  CA    . GLU A 1 188 ? 8.081   0.552   -20.564  1    28.617  ? 188  GLU A CA    1 ? 
ATOM   1573  C  C     . GLU A 1 188 ? 8.876   0.698   -21.865  1    35.032  ? 188  GLU A C     1 ? 
ATOM   1574  O  O     . GLU A 1 188 ? 10.012  0.237   -21.956  1    37.105  ? 188  GLU A O     1 ? 
ATOM   1575  C  CB    . GLU A 1 188 ? 7.07    -0.583  -20.6    1    28.018  ? 188  GLU A CB    1 ? 
ATOM   1576  C  CG    . GLU A 1 188 ? 6.544   -0.939  -19.214  1    26.996  ? 188  GLU A CG    1 ? 
ATOM   1577  C  CD    . GLU A 1 188 ? 7.629   -1.619  -18.392  1    30.678  ? 188  GLU A CD    1 ? 
ATOM   1578  O  OE1   . GLU A 1 188 ? 7.953   -2.807  -18.647  1    34.494  ? 188  GLU A OE1   1 ? 
ATOM   1579  O  OE2   . GLU A 1 188 ? 8.169   -0.939  -17.496  1    35.93   ? 188  GLU A OE2   1 ? 
ATOM   1580  N  N     . LYS A 1 189 ? 8.311   1.402   -22.849  1    35.51   ? 189  LYS A N     1 ? 
ATOM   1581  C  CA    . LYS A 1 189 ? 8.95    1.556   -24.151  1    39.699  ? 189  LYS A CA    1 ? 
ATOM   1582  C  C     . LYS A 1 189 ? 10.184  2.455   -24.038  1    43.564  ? 189  LYS A C     1 ? 
ATOM   1583  O  O     . LYS A 1 189 ? 11.123  2.289   -24.819  1    43.238  ? 189  LYS A O     1 ? 
ATOM   1584  C  CB    . LYS A 1 189 ? 8.042   2.112   -25.251  1    44.338  ? 189  LYS A CB    1 ? 
ATOM   1585  C  CG    . LYS A 1 189 ? 6.917   1.243   -25.818  1    48.832  ? 189  LYS A CG    1 ? 
ATOM   1586  C  CD    . LYS A 1 189 ? 5.994   1.967   -26.803  1    50.913  ? 189  LYS A CD    1 ? 
ATOM   1587  C  CE    . LYS A 1 189 ? 6.526   2.179   -28.218  1    49.597  ? 189  LYS A CE    1 ? 
ATOM   1588  N  NZ    . LYS A 1 189 ? 6.262   1.064   -29.135  1    48.431  ? 189  LYS A NZ    1 ? 
ATOM   1589  N  N     . ALA A 1 190 ? 10.176  3.384   -23.066  1    42.971  ? 190  ALA A N     1 ? 
ATOM   1590  C  CA    . ALA A 1 190 ? 11.251  4.345   -22.839  1    48.31   ? 190  ALA A CA    1 ? 
ATOM   1591  C  C     . ALA A 1 190 ? 12.53   3.651   -22.398  1    52.328  ? 190  ALA A C     1 ? 
ATOM   1592  O  O     . ALA A 1 190 ? 13.602  4.218   -22.563  1    58.805  ? 190  ALA A O     1 ? 
ATOM   1593  C  CB    . ALA A 1 190 ? 10.878  5.38    -21.799  1    42.684  ? 190  ALA A CB    1 ? 
ATOM   1594  N  N     . LYS A 1 191 ? 12.402  2.45    -21.819  1    53.061  ? 191  LYS A N     1 ? 
ATOM   1595  C  CA    . LYS A 1 191 ? 13.544  1.712   -21.295  1    53.379  ? 191  LYS A CA    1 ? 
ATOM   1596  C  C     . LYS A 1 191 ? 14.451  1.176   -22.411  1    55.093  ? 191  LYS A C     1 ? 
ATOM   1597  O  O     . LYS A 1 191 ? 13.982  0.548   -23.368  1    45.087  ? 191  LYS A O     1 ? 
ATOM   1598  C  CB    . LYS A 1 191 ? 13.066  0.58    -20.38   1    48.336  ? 191  LYS A CB    1 ? 
ATOM   1599  C  CG    . LYS A 1 191 ? 12.579  1.05    -19.012  1    48.946  ? 191  LYS A CG    1 ? 
ATOM   1600  C  CD    . LYS A 1 191 ? 11.96   -0.139  -18.286  1    51.376  ? 191  LYS A CD    1 ? 
ATOM   1601  C  CE    . LYS A 1 191 ? 11.383  0.076   -16.928  1    45.076  ? 191  LYS A CE    1 ? 
ATOM   1602  N  NZ    . LYS A 1 191 ? 10.831  -1.23   -16.563  1    38.54   ? 191  LYS A NZ    1 ? 
ATOM   1603  N  N     . PRO A 1 192 ? 15.796  1.332   -22.275  1    55.967  ? 192  PRO A N     1 ? 
ATOM   1604  C  CA    . PRO A 1 192 ? 16.758  0.789   -23.247  1    54.694  ? 192  PRO A CA    1 ? 
ATOM   1605  C  C     . PRO A 1 192 ? 16.604  -0.7    -23.573  1    50.835  ? 192  PRO A C     1 ? 
ATOM   1606  O  O     . PRO A 1 192 ? 16.709  -1.107  -24.732  1    53.661  ? 192  PRO A O     1 ? 
ATOM   1607  C  CB    . PRO A 1 192 ? 18.117  1.09    -22.574  1    62.986  ? 192  PRO A CB    1 ? 
ATOM   1608  C  CG    . PRO A 1 192 ? 17.789  1.249   -21.096  1    63.861  ? 192  PRO A CG    1 ? 
ATOM   1609  C  CD    . PRO A 1 192 ? 16.459  1.988   -21.134  1    58.837  ? 192  PRO A CD    1 ? 
ATOM   1610  N  N     . ASP A 1 193 ? 16.3    -1.497  -22.542  1    49.204  ? 193  ASP A N     1 ? 
ATOM   1611  C  CA    . ASP A 1 193 ? 16.192  -2.941  -22.668  1    49.223  ? 193  ASP A CA    1 ? 
ATOM   1612  C  C     . ASP A 1 193 ? 14.75   -3.394  -22.926  1    45.639  ? 193  ASP A C     1 ? 
ATOM   1613  O  O     . ASP A 1 193 ? 14.438  -4.576  -22.789  1    48.991  ? 193  ASP A O     1 ? 
ATOM   1614  C  CB    . ASP A 1 193 ? 16.732  -3.624  -21.421  1    58.139  ? 193  ASP A CB    1 ? 
ATOM   1615  C  CG    . ASP A 1 193 ? 15.983  -3.319  -20.127  1    65.04   ? 193  ASP A CG    1 ? 
ATOM   1616  O  OD1   . ASP A 1 193 ? 15.124  -2.406  -20.122  1    62.999  ? 193  ASP A OD1   1 ? 
ATOM   1617  O  OD2   . ASP A 1 193 ? 16.26   -4.006  -19.128  1    70.377  ? 193  ASP A OD2   1 ? 
ATOM   1618  N  N     . HIS A 1 194 ? 13.863  -2.476  -23.314  1    47.7    ? 194  HIS A N     1 ? 
ATOM   1619  C  CA    . HIS A 1 194 ? 12.506  -2.896  -23.629  1    42.902  ? 194  HIS A CA    1 ? 
ATOM   1620  C  C     . HIS A 1 194 ? 12.567  -3.876  -24.793  1    46.988  ? 194  HIS A C     1 ? 
ATOM   1621  O  O     . HIS A 1 194 ? 13.224  -3.619  -25.796  1    48.148  ? 194  HIS A O     1 ? 
ATOM   1622  C  CB    . HIS A 1 194 ? 11.613  -1.734  -24.084  1    37.351  ? 194  HIS A CB    1 ? 
ATOM   1623  C  CG    . HIS A 1 194 ? 10.181  -2.159  -24.282  1    45.859  ? 194  HIS A CG    1 ? 
ATOM   1624  N  ND1   . HIS A 1 194 ? 9.458   -2.887  -23.349  1    43.687  ? 194  HIS A ND1   1 ? 
ATOM   1625  C  CD2   . HIS A 1 194 ? 9.338   -1.937  -25.316  1    44.792  ? 194  HIS A CD2   1 ? 
ATOM   1626  C  CE1   . HIS A 1 194 ? 8.23    -3.109  -23.81   1    44.743  ? 194  HIS A CE1   1 ? 
ATOM   1627  N  NE2   . HIS A 1 194 ? 8.139   -2.548  -25.014  1    46.367  ? 194  HIS A NE2   1 ? 
ATOM   1628  N  N     . ASP A 1 195 ? 11.834  -4.977  -24.654  1    41.562  ? 195  ASP A N     1 ? 
ATOM   1629  C  CA    . ASP A 1 195 ? 11.8    -6.008  -25.664  1    35.997  ? 195  ASP A CA    1 ? 
ATOM   1630  C  C     . ASP A 1 195 ? 10.67   -5.708  -26.644  1    40.011  ? 195  ASP A C     1 ? 
ATOM   1631  O  O     . ASP A 1 195 ? 9.506   -5.834  -26.261  1    39.806  ? 195  ASP A O     1 ? 
ATOM   1632  C  CB    . ASP A 1 195 ? 11.667  -7.358  -24.976  1    39.476  ? 195  ASP A CB    1 ? 
ATOM   1633  C  CG    . ASP A 1 195 ? 11.603  -8.581  -25.871  1    42.693  ? 195  ASP A CG    1 ? 
ATOM   1634  O  OD1   . ASP A 1 195 ? 11.429  -8.419  -27.102  1    43.404  ? 195  ASP A OD1   1 ? 
ATOM   1635  O  OD2   . ASP A 1 195 ? 11.72   -9.691  -25.318  1    41.986  ? 195  ASP A OD2   1 ? 
ATOM   1636  N  N     . PRO A 1 196 ? 10.972  -5.411  -27.941  1    40.518  ? 196  PRO A N     1 ? 
ATOM   1637  C  CA    . PRO A 1 196 ? 9.954   -5.081  -28.944  1    40.824  ? 196  PRO A CA    1 ? 
ATOM   1638  C  C     . PRO A 1 196 ? 8.988   -6.238  -29.147  1    40.048  ? 196  PRO A C     1 ? 
ATOM   1639  O  O     . PRO A 1 196 ? 7.91    -6.052  -29.705  1    45.731  ? 196  PRO A O     1 ? 
ATOM   1640  C  CB    . PRO A 1 196 ? 10.755  -4.812  -30.246  1    40.34   ? 196  PRO A CB    1 ? 
ATOM   1641  C  CG    . PRO A 1 196 ? 12.034  -5.598  -30.022  1    41.75   ? 196  PRO A CG    1 ? 
ATOM   1642  C  CD    . PRO A 1 196 ? 12.327  -5.379  -28.529  1    39.155  ? 196  PRO A CD    1 ? 
ATOM   1643  N  N     . ASN A 1 197 ? 9.377   -7.42   -28.668  1    35.061  ? 197  ASN A N     1 ? 
ATOM   1644  C  CA    . ASN A 1 197 ? 8.557   -8.598  -28.896  1    41.64   ? 197  ASN A CA    1 ? 
ATOM   1645  C  C     . ASN A 1 197 ? 7.626   -8.87   -27.712  1    36.91   ? 197  ASN A C     1 ? 
ATOM   1646  O  O     . ASN A 1 197 ? 6.878   -9.844  -27.755  1    35.946  ? 197  ASN A O     1 ? 
ATOM   1647  C  CB    . ASN A 1 197 ? 9.388   -9.819  -29.274  1    44.848  ? 197  ASN A CB    1 ? 
ATOM   1648  C  CG    . ASN A 1 197 ? 10.059  -9.622  -30.619  1    64.989  ? 197  ASN A CG    1 ? 
ATOM   1649  O  OD1   . ASN A 1 197 ? 9.386   -9.281  -31.611  1    55.325  ? 197  ASN A OD1   1 ? 
ATOM   1650  N  ND2   . ASN A 1 197 ? 11.381  -9.775  -30.653  1    52.78   ? 197  ASN A ND2   1 ? 
ATOM   1651  N  N     . THR A 1 198 ? 7.669   -8.023  -26.668  1    34.228  ? 198  THR A N     1 ? 
ATOM   1652  C  CA    . THR A 1 198 ? 6.739   -8.156  -25.547  1    30.727  ? 198  THR A CA    1 ? 
ATOM   1653  C  C     . THR A 1 198 ? 5.336   -8.47   -26.082  1    27.02   ? 198  THR A C     1 ? 
ATOM   1654  O  O     . THR A 1 198 ? 4.865   -7.801  -27.001  1    33.945  ? 198  THR A O     1 ? 
ATOM   1655  C  CB    . THR A 1 198 ? 6.707   -6.858  -24.734  1    28.803  ? 198  THR A CB    1 ? 
ATOM   1656  O  OG1   . THR A 1 198 ? 7.965   -6.766  -24.082  1    32.926  ? 198  THR A OG1   1 ? 
ATOM   1657  C  CG2   . THR A 1 198 ? 5.737   -6.954  -23.57   1    32.273  ? 198  THR A CG2   1 ? 
ATOM   1658  N  N     . ARG A 1 199 ? 4.661   -9.476  -25.515  1    27.094  ? 199  ARG A N     1 ? 
ATOM   1659  C  CA    . ARG A 1 199 ? 3.296   -9.793  -25.924  1    28.316  ? 199  ARG A CA    1 ? 
ATOM   1660  C  C     . ARG A 1 199 ? 2.293   -9.181  -24.93   1    28.665  ? 199  ARG A C     1 ? 
ATOM   1661  O  O     . ARG A 1 199 ? 2.205   -9.609  -23.769  1    24.535  ? 199  ARG A O     1 ? 
ATOM   1662  C  CB    . ARG A 1 199 ? 3.113   -11.318 -25.966  1    26.733  ? 199  ARG A CB    1 ? 
ATOM   1663  C  CG    . ARG A 1 199 ? 3.8     -12.038 -27.129  1    35.024  ? 199  ARG A CG    1 ? 
ATOM   1664  C  CD    . ARG A 1 199 ? 4.052   -13.534 -26.887  1    34.851  ? 199  ARG A CD    1 ? 
ATOM   1665  N  NE    . ARG A 1 199 ? 4.84    -13.726 -25.659  1    34.321  ? 199  ARG A NE    1 ? 
ATOM   1666  C  CZ    . ARG A 1 199 ? 5.262   -14.894 -25.147  1    41.499  ? 199  ARG A CZ    1 ? 
ATOM   1667  N  NH1   . ARG A 1 199 ? 4.905   -16.017 -25.747  1    37.674  ? 199  ARG A NH1   1 ? 
ATOM   1668  N  NH2   . ARG A 1 199 ? 5.985   -14.946 -24.01   1    30.4    ? 199  ARG A NH2   1 ? 
ATOM   1669  N  N     . HIS A 1 200 ? 1.514   -8.199  -25.407  1    29.221  ? 200  HIS A N     1 ? 
ATOM   1670  C  CA    . HIS A 1 200 ? 0.597   -7.459  -24.551  1    26.064  ? 200  HIS A CA    1 ? 
ATOM   1671  C  C     . HIS A 1 200 ? -0.83   -7.926  -24.784  1    28.358  ? 200  HIS A C     1 ? 
ATOM   1672  O  O     . HIS A 1 200 ? -1.244  -8.143  -25.92   1    27.835  ? 200  HIS A O     1 ? 
ATOM   1673  C  CB    . HIS A 1 200 ? 0.61    -5.95   -24.839  1    25.914  ? 200  HIS A CB    1 ? 
ATOM   1674  C  CG    . HIS A 1 200 ? 1.942   -5.299  -24.921  1    24.734  ? 200  HIS A CG    1 ? 
ATOM   1675  N  ND1   . HIS A 1 200 ? 2.513   -4.59   -23.888  1    25.289  ? 200  HIS A ND1   1 ? 
ATOM   1676  C  CD2   . HIS A 1 200 ? 2.809   -5.241  -25.951  1    27.234  ? 200  HIS A CD2   1 ? 
ATOM   1677  C  CE1   . HIS A 1 200 ? 3.683   -4.098  -24.286  1    24.846  ? 200  HIS A CE1   1 ? 
ATOM   1678  N  NE2   . HIS A 1 200 ? 3.88    -4.478  -25.552  1    27.123  ? 200  HIS A NE2   1 ? 
ATOM   1679  N  N     . CYS A 1 201 ? -1.569  -8.039  -23.681  1    27.715  ? 201  CYS A N     1 ? 
ATOM   1680  C  CA    . CYS A 1 201 ? -2.979  -8.337  -23.719  1    25.857  ? 201  CYS A CA    1 ? 
ATOM   1681  C  C     . CYS A 1 201 ? -3.733  -7.267  -22.928  1    30.172  ? 201  CYS A C     1 ? 
ATOM   1682  O  O     . CYS A 1 201 ? -3.407  -6.952  -21.769  1    28.44   ? 201  CYS A O     1 ? 
ATOM   1683  C  CB    . CYS A 1 201 ? -3.242  -9.714  -23.151  1    28.196  ? 201  CYS A CB    1 ? 
ATOM   1684  S  SG    . CYS A 1 201 ? -4.986  -10.16  -23.335  1    33.338  ? 201  CYS A SG    1 ? 
ATOM   1685  N  N     . LEU A 1 202 ? -4.719  -6.667  -23.598  1    25.928  ? 202  LEU A N     1 ? 
ATOM   1686  C  CA    . LEU A 1 202 ? -5.565  -5.651  -22.987  1    27.841  ? 202  LEU A CA    1 ? 
ATOM   1687  C  C     . LEU A 1 202 ? -6.996  -6.192  -22.983  1    28.548  ? 202  LEU A C     1 ? 
ATOM   1688  O  O     . LEU A 1 202 ? -7.507  -6.639  -24.012  1    26.503  ? 202  LEU A O     1 ? 
ATOM   1689  C  CB    . LEU A 1 202 ? -5.346  -4.289  -23.672  1    25.996  ? 202  LEU A CB    1 ? 
ATOM   1690  C  CG    . LEU A 1 202 ? -6.316  -3.134  -23.353  1    27.512  ? 202  LEU A CG    1 ? 
ATOM   1691  C  CD1   . LEU A 1 202 ? -6.328  -2.598  -21.923  1    22.049  ? 202  LEU A CD1   1 ? 
ATOM   1692  C  CD2   . LEU A 1 202 ? -6.106  -1.99   -24.348  1    23.929  ? 202  LEU A CD2   1 ? 
ATOM   1693  N  N     . TYR A 1 203 ? -7.579  -6.286  -21.783  1    25.885  ? 203  TYR A N     1 ? 
ATOM   1694  C  CA    . TYR A 1 203 ? -8.894  -6.869  -21.63   1    28.29   ? 203  TYR A CA    1 ? 
ATOM   1695  C  C     . TYR A 1 203 ? -9.948  -5.859  -22.077  1    29.625  ? 203  TYR A C     1 ? 
ATOM   1696  O  O     . TYR A 1 203 ? -9.84   -4.688  -21.73   1    26.978  ? 203  TYR A O     1 ? 
ATOM   1697  C  CB    . TYR A 1 203 ? -9.08   -7.245  -20.163  1    26.746  ? 203  TYR A CB    1 ? 
ATOM   1698  C  CG    . TYR A 1 203 ? -10.479 -7.759  -19.851  1    30.837  ? 203  TYR A CG    1 ? 
ATOM   1699  C  CD1   . TYR A 1 203 ? -10.817 -9.074  -20.124  1    33.136  ? 203  TYR A CD1   1 ? 
ATOM   1700  C  CD2   . TYR A 1 203 ? -11.444 -6.947  -19.25   1    28.163  ? 203  TYR A CD2   1 ? 
ATOM   1701  C  CE1   . TYR A 1 203 ? -12.091 -9.564  -19.872  1    32.785  ? 203  TYR A CE1   1 ? 
ATOM   1702  C  CE2   . TYR A 1 203 ? -12.719 -7.428  -18.981  1    34.336  ? 203  TYR A CE2   1 ? 
ATOM   1703  C  CZ    . TYR A 1 203 ? -13.042 -8.743  -19.292  1    32.553  ? 203  TYR A CZ    1 ? 
ATOM   1704  O  OH    . TYR A 1 203 ? -14.269 -9.283  -19.04   1    32.035  ? 203  TYR A OH    1 ? 
ATOM   1705  N  N     . GLY A 1 204 ? -10.963 -6.322  -22.835  1    26.953  ? 204  GLY A N     1 ? 
ATOM   1706  C  CA    . GLY A 1 204 ? -12.008 -5.429  -23.325  1    27.345  ? 204  GLY A CA    1 ? 
ATOM   1707  C  C     . GLY A 1 204 ? -11.942 -5.249  -24.844  1    28.527  ? 204  GLY A C     1 ? 
ATOM   1708  O  O     . GLY A 1 204 ? -10.934 -5.569  -25.466  1    30.978  ? 204  GLY A O     1 ? 
ATOM   1709  N  N     . LEU A 1 205 ? -13.045 -4.759  -25.415  1    27.479  ? 205  LEU A N     1 ? 
ATOM   1710  C  CA    . LEU A 1 205 ? -13.246 -4.645  -26.853  1    30.093  ? 205  LEU A CA    1 ? 
ATOM   1711  C  C     . LEU A 1 205 ? -13.656 -3.228  -27.24   1    27.983  ? 205  LEU A C     1 ? 
ATOM   1712  O  O     . LEU A 1 205 ? -13.822 -2.979  -28.424  1    30.211  ? 205  LEU A O     1 ? 
ATOM   1713  C  CB    . LEU A 1 205 ? -14.316 -5.627  -27.33   1    28.14   ? 205  LEU A CB    1 ? 
ATOM   1714  C  CG    . LEU A 1 205 ? -14.089 -7.105  -27.012  1    32.603  ? 205  LEU A CG    1 ? 
ATOM   1715  C  CD1   . LEU A 1 205 ? -15.349 -7.906  -27.43   1    32.224  ? 205  LEU A CD1   1 ? 
ATOM   1716  C  CD2   . LEU A 1 205 ? -12.817 -7.607  -27.693  1    33.043  ? 205  LEU A CD2   1 ? 
ATOM   1717  N  N     . ASP A 1 206 ? -13.732 -2.307  -26.263  1    28.808  ? 206  ASP A N     1 ? 
ATOM   1718  C  CA    . ASP A 1 206 ? -14.101 -0.905  -26.456  1    28.03   ? 206  ASP A CA    1 ? 
ATOM   1719  C  C     . ASP A 1 206 ? -13.164 -0.159  -27.4    1    29.616  ? 206  ASP A C     1 ? 
ATOM   1720  O  O     . ASP A 1 206 ? -11.942 -0.388  -27.442  1    33.665  ? 206  ASP A O     1 ? 
ATOM   1721  C  CB    . ASP A 1 206 ? -14.226 -0.193  -25.114  1    29.809  ? 206  ASP A CB    1 ? 
ATOM   1722  C  CG    . ASP A 1 206 ? -15.142 -0.939  -24.157  1    38.206  ? 206  ASP A CG    1 ? 
ATOM   1723  O  OD1   . ASP A 1 206 ? -16.372 -0.876  -24.354  1    44.988  ? 206  ASP A OD1   1 ? 
ATOM   1724  O  OD2   . ASP A 1 206 ? -14.623 -1.695  -23.31   1    44.965  ? 206  ASP A OD2   1 ? 
ATOM   1725  N  N     . ALA A 1 207 ? -13.751 0.832   -28.086  1    31.188  ? 207  ALA A N     1 ? 
ATOM   1726  C  CA    . ALA A 1 207 ? -13.078 1.556   -29.151  1    30.837  ? 207  ALA A CA    1 ? 
ATOM   1727  C  C     . ALA A 1 207 ? -11.836 2.262   -28.607  1    31.427  ? 207  ALA A C     1 ? 
ATOM   1728  O  O     . ALA A 1 207 ? -10.806 2.278   -29.282  1    29.583  ? 207  ALA A O     1 ? 
ATOM   1729  C  CB    . ALA A 1 207 ? -14.036 2.537   -29.824  1    31.041  ? 207  ALA A CB    1 ? 
ATOM   1730  N  N     . ASP A 1 208 ? -11.925 2.884   -27.412  1    28.288  ? 208  ASP A N     1 ? 
ATOM   1731  C  CA    . ASP A 1 208 ? -10.723 3.554   -26.904  1    32.312  ? 208  ASP A CA    1 ? 
ATOM   1732  C  C     . ASP A 1 208 ? -9.561  2.571   -26.679  1    27.599  ? 208  ASP A C     1 ? 
ATOM   1733  O  O     . ASP A 1 208 ? -8.395  2.958   -26.808  1    33.934  ? 208  ASP A O     1 ? 
ATOM   1734  C  CB    . ASP A 1 208 ? -10.994 4.506   -25.745  1    34.746  ? 208  ASP A CB    1 ? 
ATOM   1735  C  CG    . ASP A 1 208 ? -11.423 3.811   -24.459  1    45.865  ? 208  ASP A CG    1 ? 
ATOM   1736  O  OD1   . ASP A 1 208 ? -12.257 2.894   -24.545  1    45.902  ? 208  ASP A OD1   1 ? 
ATOM   1737  O  OD2   . ASP A 1 208 ? -10.909 4.178   -23.382  1    56.929  ? 208  ASP A OD2   1 ? 
ATOM   1738  N  N     . LEU A 1 209 ? -9.875  1.317   -26.325  1    28.012  ? 209  LEU A N     1 ? 
ATOM   1739  C  CA    . LEU A 1 209 ? -8.865  0.306   -26.07   1    28.654  ? 209  LEU A CA    1 ? 
ATOM   1740  C  C     . LEU A 1 209 ? -8.207  -0.09   -27.389  1    30.71   ? 209  LEU A C     1 ? 
ATOM   1741  O  O     . LEU A 1 209 ? -6.987  -0.246  -27.457  1    29.671  ? 209  LEU A O     1 ? 
ATOM   1742  C  CB    . LEU A 1 209 ? -9.493  -0.901  -25.376  1    27.819  ? 209  LEU A CB    1 ? 
ATOM   1743  C  CG    . LEU A 1 209 ? -10.219 -0.654  -24.052  1    30.161  ? 209  LEU A CG    1 ? 
ATOM   1744  C  CD1   . LEU A 1 209 ? -10.747 -1.998  -23.55   1    30.028  ? 209  LEU A CD1   1 ? 
ATOM   1745  C  CD2   . LEU A 1 209 ? -9.334  0.059   -23.008  1    26.732  ? 209  LEU A CD2   1 ? 
ATOM   1746  N  N     . ILE A 1 210 ? -9.019  -0.192  -28.452  1    31.095  ? 210  ILE A N     1 ? 
ATOM   1747  C  CA    . ILE A 1 210 ? -8.478  -0.522  -29.766  1    28.471  ? 210  ILE A CA    1 ? 
ATOM   1748  C  C     . ILE A 1 210 ? -7.506  0.572   -30.156  1    29.262  ? 210  ILE A C     1 ? 
ATOM   1749  O  O     . ILE A 1 210 ? -6.361  0.28    -30.511  1    28.047  ? 210  ILE A O     1 ? 
ATOM   1750  C  CB    . ILE A 1 210 ? -9.609  -0.709  -30.795  1    30.349  ? 210  ILE A CB    1 ? 
ATOM   1751  C  CG1   . ILE A 1 210 ? -10.416 -1.957  -30.443  1    30.237  ? 210  ILE A CG1   1 ? 
ATOM   1752  C  CG2   . ILE A 1 210 ? -9.08   -0.786  -32.234  1    28.683  ? 210  ILE A CG2   1 ? 
ATOM   1753  C  CD1   . ILE A 1 210 ? -11.648 -2.193  -31.296  1    34.639  ? 210  ILE A CD1   1 ? 
ATOM   1754  N  N     . MET A 1 211 ? -7.942  1.826   -29.953  1    27.085  ? 211  MET A N     1 ? 
ATOM   1755  C  CA    . MET A 1 211 ? -7.162  2.975   -30.374  1    26.025  ? 211  MET A CA    1 ? 
ATOM   1756  C  C     . MET A 1 211 ? -5.89   3.078   -29.548  1    28.064  ? 211  MET A C     1 ? 
ATOM   1757  O  O     . MET A 1 211 ? -4.849  3.41    -30.091  1    26.978  ? 211  MET A O     1 ? 
ATOM   1758  C  CB    . MET A 1 211 ? -7.939  4.293   -30.263  1    26.773  ? 211  MET A CB    1 ? 
ATOM   1759  C  CG    . MET A 1 211 ? -9.129  4.383   -31.187  1    36.234  ? 211  MET A CG    1 ? 
ATOM   1760  S  SD    . MET A 1 211 ? -8.591  4.038   -32.877  1    42.716  ? 211  MET A SD    1 ? 
ATOM   1761  C  CE    . MET A 1 211 ? -10.186 4.426   -33.615  1    48.051  ? 211  MET A CE    1 ? 
ATOM   1762  N  N     . LEU A 1 212 ? -5.973  2.815   -28.237  1    23.88   ? 212  LEU A N     1 ? 
ATOM   1763  C  CA    A LEU A 1 212 ? -4.781  2.907   -27.405  0.5  24.33   ? 212  LEU A CA    1 ? 
ATOM   1764  C  CA    B LEU A 1 212 ? -4.773  2.92    -27.414  0.5  25.704  ? 212  LEU A CA    1 ? 
ATOM   1765  C  C     . LEU A 1 212 ? -3.753  1.855   -27.82   1    25.144  ? 212  LEU A C     1 ? 
ATOM   1766  O  O     . LEU A 1 212 ? -2.572  2.165   -27.947  1    27.359  ? 212  LEU A O     1 ? 
ATOM   1767  C  CB    A LEU A 1 212 ? -5.175  2.821   -25.932  0.5  22.483  ? 212  LEU A CB    1 ? 
ATOM   1768  C  CB    B LEU A 1 212 ? -5.014  3.01    -25.903  0.5  26.379  ? 212  LEU A CB    1 ? 
ATOM   1769  C  CG    A LEU A 1 212 ? -5.737  4.126   -25.352  0.5  23.196  ? 212  LEU A CG    1 ? 
ATOM   1770  C  CG    B LEU A 1 212 ? -5.026  1.728   -25.059  0.5  30.048  ? 212  LEU A CG    1 ? 
ATOM   1771  C  CD1   A LEU A 1 212 ? -6.518  3.941   -24.067  0.5  22.951  ? 212  LEU A CD1   1 ? 
ATOM   1772  C  CD1   B LEU A 1 212 ? -3.605  1.344   -24.623  0.5  32.536  ? 212  LEU A CD1   1 ? 
ATOM   1773  C  CD2   A LEU A 1 212 ? -4.584  5.094   -25.118  0.5  24.92   ? 212  LEU A CD2   1 ? 
ATOM   1774  C  CD2   B LEU A 1 212 ? -5.85   1.955   -23.799  0.5  30.781  ? 212  LEU A CD2   1 ? 
ATOM   1775  N  N     . GLY A 1 213 ? -4.218  0.617   -28.025  1    25.102  ? 213  GLY A N     1 ? 
ATOM   1776  C  CA    . GLY A 1 213 ? -3.39   -0.469  -28.555  1    30.421  ? 213  GLY A CA    1 ? 
ATOM   1777  C  C     . GLY A 1 213 ? -2.576  -0.06   -29.788  1    33.583  ? 213  GLY A C     1 ? 
ATOM   1778  O  O     . GLY A 1 213 ? -1.364  -0.271  -29.832  1    31.105  ? 213  GLY A O     1 ? 
ATOM   1779  N  N     . LEU A 1 214 ? -3.262  0.545   -30.776  1    32.525  ? 214  LEU A N     1 ? 
ATOM   1780  C  CA    . LEU A 1 214 ? -2.659  1.012   -32.01   1    29.521  ? 214  LEU A CA    1 ? 
ATOM   1781  C  C     . LEU A 1 214 ? -1.739  2.186   -31.737  1    35.997  ? 214  LEU A C     1 ? 
ATOM   1782  O  O     . LEU A 1 214 ? -0.673  2.285   -32.356  1    36.399  ? 214  LEU A O     1 ? 
ATOM   1783  C  CB    . LEU A 1 214 ? -3.697  1.356   -33.079  1    31.384  ? 214  LEU A CB    1 ? 
ATOM   1784  C  CG    . LEU A 1 214 ? -4.481  0.176   -33.677  1    32.925  ? 214  LEU A CG    1 ? 
ATOM   1785  C  CD1   . LEU A 1 214 ? -5.645  0.659   -34.547  1    28.792  ? 214  LEU A CD1   1 ? 
ATOM   1786  C  CD2   . LEU A 1 214 ? -3.585  -0.788  -34.471  1    35.336  ? 214  LEU A CD2   1 ? 
ATOM   1787  N  N     . THR A 1 215 ? -2.154  3.082   -30.825  1    31.862  ? 215  THR A N     1 ? 
ATOM   1788  C  CA    . THR A 1 215 ? -1.336  4.244   -30.529  1    28.832  ? 215  THR A CA    1 ? 
ATOM   1789  C  C     . THR A 1 215 ? -0.005  3.816   -29.899  1    30.534  ? 215  THR A C     1 ? 
ATOM   1790  O  O     . THR A 1 215 ? 0.995   4.536   -29.965  1    31.149  ? 215  THR A O     1 ? 
ATOM   1791  C  CB    . THR A 1 215 ? -2.1    5.154   -29.578  1    29.025  ? 215  THR A CB    1 ? 
ATOM   1792  O  OG1   . THR A 1 215 ? -3.263  5.651   -30.227  1    31.221  ? 215  THR A OG1   1 ? 
ATOM   1793  C  CG2   . THR A 1 215 ? -1.249  6.304   -29.106  1    26.968  ? 215  THR A CG2   1 ? 
ATOM   1794  N  N     . SER A 1 216 ? 0.001   2.666   -29.236  1    28.79   ? 216  SER A N     1 ? 
ATOM   1795  C  CA    . SER A 1 216 ? 1.237   2.191   -28.633  1    34.027  ? 216  SER A CA    1 ? 
ATOM   1796  C  C     . SER A 1 216 ? 2.313   1.887   -29.679  1    32.505  ? 216  SER A C     1 ? 
ATOM   1797  O  O     . SER A 1 216 ? 3.497   1.91    -29.345  1    34.972  ? 216  SER A O     1 ? 
ATOM   1798  C  CB    . SER A 1 216 ? 0.997   0.97    -27.77   1    34.537  ? 216  SER A CB    1 ? 
ATOM   1799  O  OG    . SER A 1 216 ? 0.896   -0.203  -28.563  1    31.521  ? 216  SER A OG    1 ? 
ATOM   1800  N  N     . HIS A 1 217 ? 1.907   1.547   -30.914  1    31.928  ? 217  HIS A N     1 ? 
ATOM   1801  C  CA    . HIS A 1 217 ? 2.836   1.092   -31.945  1    35.486  ? 217  HIS A CA    1 ? 
ATOM   1802  C  C     . HIS A 1 217 ? 3.642   -0.119  -31.476  1    38.59   ? 217  HIS A C     1 ? 
ATOM   1803  O  O     . HIS A 1 217 ? 4.74    -0.365  -31.975  1    38.361  ? 217  HIS A O     1 ? 
ATOM   1804  C  CB    . HIS A 1 217 ? 3.79    2.204   -32.401  1    34.973  ? 217  HIS A CB    1 ? 
ATOM   1805  C  CG    . HIS A 1 217 ? 3.058   3.229   -33.2    1    43.119  ? 217  HIS A CG    1 ? 
ATOM   1806  N  ND1   . HIS A 1 217 ? 2.839   3.086   -34.552  1    42.227  ? 217  HIS A ND1   1 ? 
ATOM   1807  C  CD2   . HIS A 1 217 ? 2.439   4.366   -32.842  1    41.293  ? 217  HIS A CD2   1 ? 
ATOM   1808  C  CE1   . HIS A 1 217 ? 2.143   4.118   -35.003  1    38.17   ? 217  HIS A CE1   1 ? 
ATOM   1809  N  NE2   . HIS A 1 217 ? 1.887   4.911   -33.98   1    41.865  ? 217  HIS A NE2   1 ? 
ATOM   1810  N  N     . GLU A 1 218 ? 3.087   -0.873  -30.526  1    38.187  ? 218  GLU A N     1 ? 
ATOM   1811  C  CA    . GLU A 1 218 ? 3.717   -2.105  -30.091  1    34.944  ? 218  GLU A CA    1 ? 
ATOM   1812  C  C     . GLU A 1 218 ? 3.406   -3.188  -31.124  1    35.942  ? 218  GLU A C     1 ? 
ATOM   1813  O  O     . GLU A 1 218 ? 2.274   -3.294  -31.58   1    38.222  ? 218  GLU A O     1 ? 
ATOM   1814  C  CB    . GLU A 1 218 ? 3.228   -2.445  -28.679  1    32.849  ? 218  GLU A CB    1 ? 
ATOM   1815  C  CG    . GLU A 1 218 ? 3.945   -1.677  -27.558  1    34.084  ? 218  GLU A CG    1 ? 
ATOM   1816  C  CD    . GLU A 1 218 ? 5.444   -1.986  -27.421  1    38.13   ? 218  GLU A CD    1 ? 
ATOM   1817  O  OE1   . GLU A 1 218 ? 6.22    -1.156  -27.918  1    42.558  ? 218  GLU A OE1   1 ? 
ATOM   1818  O  OE2   . GLU A 1 218 ? 5.868   -3.022  -26.853  1    38.285  ? 218  GLU A OE2   1 ? 
ATOM   1819  N  N     . ALA A 1 219 ? 4.396   -4.015  -31.466  1    36.026  ? 219  ALA A N     1 ? 
ATOM   1820  C  CA    . ALA A 1 219 ? 4.21    -4.998  -32.533  1    37.487  ? 219  ALA A CA    1 ? 
ATOM   1821  C  C     . ALA A 1 219 ? 3.224   -6.109  -32.176  1    37.134  ? 219  ALA A C     1 ? 
ATOM   1822  O  O     . ALA A 1 219 ? 2.515   -6.603  -33.058  1    40.461  ? 219  ALA A O     1 ? 
ATOM   1823  C  CB    . ALA A 1 219 ? 5.537   -5.545  -33.02   1    36.093  ? 219  ALA A CB    1 ? 
ATOM   1824  N  N     . HIS A 1 220 ? 3.156   -6.523  -30.904  1    36.605  ? 220  HIS A N     1 ? 
ATOM   1825  C  CA    . HIS A 1 220 ? 2.265   -7.633  -30.57   1    36.559  ? 220  HIS A CA    1 ? 
ATOM   1826  C  C     . HIS A 1 220 ? 1.359   -7.24   -29.409  1    37.897  ? 220  HIS A C     1 ? 
ATOM   1827  O  O     . HIS A 1 220 ? 1.646   -7.499  -28.238  1    38.919  ? 220  HIS A O     1 ? 
ATOM   1828  C  CB    . HIS A 1 220 ? 3.046   -8.88   -30.137  1    42.508  ? 220  HIS A CB    1 ? 
ATOM   1829  C  CG    . HIS A 1 220 ? 4.108   -9.262  -31.1    1    49.029  ? 220  HIS A CG    1 ? 
ATOM   1830  N  ND1   . HIS A 1 220 ? 3.85    -10.05  -32.204  1    49.494  ? 220  HIS A ND1   1 ? 
ATOM   1831  C  CD2   . HIS A 1 220 ? 5.411   -8.931  -31.159  1    50.755  ? 220  HIS A CD2   1 ? 
ATOM   1832  C  CE1   . HIS A 1 220 ? 4.978   -10.205 -32.891  1    54.675  ? 220  HIS A CE1   1 ? 
ATOM   1833  N  NE2   . HIS A 1 220 ? 5.939   -9.535  -32.275  1    55.022  ? 220  HIS A NE2   1 ? 
ATOM   1834  N  N     . PHE A 1 221 ? 0.224   -6.657  -29.753  1    33.109  ? 221  PHE A N     1 ? 
ATOM   1835  C  CA    . PHE A 1 221 ? -0.701  -6.205  -28.736  1    30.732  ? 221  PHE A CA    1 ? 
ATOM   1836  C  C     . PHE A 1 221 ? -2.052  -6.771  -29.139  1    29.302  ? 221  PHE A C     1 ? 
ATOM   1837  O  O     . PHE A 1 221 ? -2.431  -6.63   -30.292  1    27.064  ? 221  PHE A O     1 ? 
ATOM   1838  C  CB    . PHE A 1 221 ? -0.638  -4.678  -28.894  1    29.129  ? 221  PHE A CB    1 ? 
ATOM   1839  C  CG    . PHE A 1 221 ? -1.21   -3.96   -27.686  1    27.098  ? 221  PHE A CG    1 ? 
ATOM   1840  C  CD1   . PHE A 1 221 ? -2.575  -4.014  -27.409  1    28.782  ? 221  PHE A CD1   1 ? 
ATOM   1841  C  CD2   . PHE A 1 221 ? -0.395  -3.194  -26.88   1    27.685  ? 221  PHE A CD2   1 ? 
ATOM   1842  C  CE1   . PHE A 1 221 ? -3.107  -3.353  -26.31   1    32.972  ? 221  PHE A CE1   1 ? 
ATOM   1843  C  CE2   . PHE A 1 221 ? -0.922  -2.571  -25.758  1    29.515  ? 221  PHE A CE2   1 ? 
ATOM   1844  C  CZ    . PHE A 1 221 ? -2.27   -2.644  -25.482  1    31.285  ? 221  PHE A CZ    1 ? 
ATOM   1845  N  N     . SER A 1 222 ? -2.733  -7.439  -28.21   1    26.725  ? 222  SER A N     1 ? 
ATOM   1846  C  CA    . SER A 1 222 ? -3.995  -8.08   -28.504  1    28.078  ? 222  SER A CA    1 ? 
ATOM   1847  C  C     . SER A 1 222 ? -5.023  -7.605  -27.495  1    30.493  ? 222  SER A C     1 ? 
ATOM   1848  O  O     . SER A 1 222 ? -4.643  -7.219  -26.403  1    26.988  ? 222  SER A O     1 ? 
ATOM   1849  C  CB    . SER A 1 222 ? -3.858  -9.586  -28.46   1    30.055  ? 222  SER A CB    1 ? 
ATOM   1850  O  OG    . SER A 1 222 ? -2.724  -9.975  -29.226  1    30.685  ? 222  SER A OG    1 ? 
ATOM   1851  N  N     . LEU A 1 223 ? -6.302  -7.622  -27.898  1    30.417  ? 223  LEU A N     1 ? 
ATOM   1852  C  CA    . LEU A 1 223 ? -7.437  -7.422  -27.016  1    29.821  ? 223  LEU A CA    1 ? 
ATOM   1853  C  C     . LEU A 1 223 ? -8.173  -8.75   -26.889  1    27.565  ? 223  LEU A C     1 ? 
ATOM   1854  O  O     . LEU A 1 223 ? -8.213  -9.519  -27.831  1    36.453  ? 223  LEU A O     1 ? 
ATOM   1855  C  CB    . LEU A 1 223 ? -8.357  -6.289  -27.479  1    26.17   ? 223  LEU A CB    1 ? 
ATOM   1856  C  CG    . LEU A 1 223 ? -7.826  -4.867  -27.263  1    31.953  ? 223  LEU A CG    1 ? 
ATOM   1857  C  CD1   . LEU A 1 223 ? -6.485  -4.708  -27.892  1    36.379  ? 223  LEU A CD1   1 ? 
ATOM   1858  C  CD2   . LEU A 1 223 ? -8.777  -3.935  -27.987  1    36.257  ? 223  LEU A CD2   1 ? 
ATOM   1859  N  N     . LEU A 1 224 ? -8.783  -8.978  -25.728  1    26.674  ? 224  LEU A N     1 ? 
ATOM   1860  C  CA    . LEU A 1 224 ? -9.452  -10.222 -25.402  1    29.501  ? 224  LEU A CA    1 ? 
ATOM   1861  C  C     . LEU A 1 224 ? -10.607 -9.875  -24.486  1    29.673  ? 224  LEU A C     1 ? 
ATOM   1862  O  O     . LEU A 1 224 ? -10.466 -8.979  -23.644  1    31.343  ? 224  LEU A O     1 ? 
ATOM   1863  C  CB    . LEU A 1 224 ? -8.394  -11.073 -24.692  1    33.578  ? 224  LEU A CB    1 ? 
ATOM   1864  C  CG    . LEU A 1 224 ? -8.784  -12.487 -24.246  1    39.942  ? 224  LEU A CG    1 ? 
ATOM   1865  C  CD1   . LEU A 1 224 ? -7.511  -13.279 -24.18   1    47.214  ? 224  LEU A CD1   1 ? 
ATOM   1866  C  CD2   . LEU A 1 224 ? -9.349  -12.434 -22.853  1    44.795  ? 224  LEU A CD2   1 ? 
ATOM   1867  N  N     . ARG A 1 225 ? -11.74  -10.562 -24.682  1    29.965  ? 225  ARG A N     1 ? 
ATOM   1868  C  CA    . ARG A 1 225 ? -12.886 -10.475 -23.779  1    32.679  ? 225  ARG A CA    1 ? 
ATOM   1869  C  C     . ARG A 1 225 ? -13.714 -11.739 -23.949  1    27.403  ? 225  ARG A C     1 ? 
ATOM   1870  O  O     . ARG A 1 225 ? -13.775 -12.292 -25.027  1    33.591  ? 225  ARG A O     1 ? 
ATOM   1871  C  CB    . ARG A 1 225 ? -13.838 -9.311  -24.055  1    32.774  ? 225  ARG A CB    1 ? 
ATOM   1872  C  CG    . ARG A 1 225 ? -14.705 -8.909  -22.867  1    33.434  ? 225  ARG A CG    1 ? 
ATOM   1873  C  CD    . ARG A 1 225 ? -15.867 -8.071  -23.412  1    32.285  ? 225  ARG A CD    1 ? 
ATOM   1874  N  NE    . ARG A 1 225 ? -16.698 -9.076  -24.076  1    35.641  ? 225  ARG A NE    1 ? 
ATOM   1875  C  CZ    . ARG A 1 225 ? -17.812 -8.926  -24.782  1    40.149  ? 225  ARG A CZ    1 ? 
ATOM   1876  N  NH1   . ARG A 1 225 ? -18.427 -10.013 -25.211  1    39.098  ? 225  ARG A NH1   1 ? 
ATOM   1877  N  NH2   . ARG A 1 225 ? -18.308 -7.722  -25.071  1    36.266  ? 225  ARG A NH2   1 ? 
ATOM   1878  N  N     . GLU A 1 226 ? -14.316 -12.221 -22.881  1    31.642  ? 226  GLU A N     1 ? 
ATOM   1879  C  CA    . GLU A 1 226 ? -15.085 -13.452 -22.954  1    34.7    ? 226  GLU A CA    1 ? 
ATOM   1880  C  C     . GLU A 1 226 ? -16.337 -13.2   -23.789  1    38.766  ? 226  GLU A C     1 ? 
ATOM   1881  O  O     . GLU A 1 226 ? -16.939 -12.131 -23.697  1    37.832  ? 226  GLU A O     1 ? 
ATOM   1882  C  CB    . GLU A 1 226 ? -15.487 -14.009 -21.591  1    39.34   ? 226  GLU A CB    1 ? 
ATOM   1883  C  CG    . GLU A 1 226 ? -16.454 -13.13  -20.803  1    40.22   ? 226  GLU A CG    1 ? 
ATOM   1884  C  CD    . GLU A 1 226 ? -15.863 -11.902 -20.148  1    50.094  ? 226  GLU A CD    1 ? 
ATOM   1885  O  OE1   . GLU A 1 226 ? -14.684 -11.555 -20.412  1    49.19   ? 226  GLU A OE1   1 ? 
ATOM   1886  O  OE2   . GLU A 1 226 ? -16.594 -11.305 -19.333  1    51.187  ? 226  GLU A OE2   1 ? 
ATOM   1887  N  N     . GLU A 1 227 ? -16.68  -14.203 -24.606  1    42.031  ? 227  GLU A N     1 ? 
ATOM   1888  C  CA    . GLU A 1 227 ? -17.786 -14.141 -25.55   1    46.868  ? 227  GLU A CA    1 ? 
ATOM   1889  C  C     . GLU A 1 227 ? -19.101 -13.949 -24.798  1    47.686  ? 227  GLU A C     1 ? 
ATOM   1890  O  O     . GLU A 1 227 ? -19.908 -13.123 -25.21   1    48.97   ? 227  GLU A O     1 ? 
ATOM   1891  C  CB    . GLU A 1 227 ? -17.773 -15.396 -26.419  1    48.642  ? 227  GLU A CB    1 ? 
ATOM   1892  C  CG    . GLU A 1 227 ? -18.533 -15.202 -27.729  1    61.688  ? 227  GLU A CG    1 ? 
ATOM   1893  C  CD    . GLU A 1 227 ? -18.867 -16.462 -28.515  1    64.994  ? 227  GLU A CD    1 ? 
ATOM   1894  O  OE1   . GLU A 1 227 ? -18.437 -17.563 -28.099  1    67.685  ? 227  GLU A OE1   1 ? 
ATOM   1895  O  OE2   . GLU A 1 227 ? -19.578 -16.34  -29.538  1    60.684  ? 227  GLU A OE2   1 ? 
ATOM   1896  N  N     . VAL A 1 228 ? -19.284 -14.7   -23.698  1    49.599  ? 228  VAL A N     1 ? 
ATOM   1897  C  CA    . VAL A 1 228 ? -20.445 -14.615 -22.824  1    57.759  ? 228  VAL A CA    1 ? 
ATOM   1898  C  C     . VAL A 1 228 ? -19.925 -14.297 -21.431  1    65.732  ? 228  VAL A C     1 ? 
ATOM   1899  O  O     . VAL A 1 228 ? -18.985 -14.944 -20.972  1    70.534  ? 228  VAL A O     1 ? 
ATOM   1900  C  CB    . VAL A 1 228 ? -21.285 -15.909 -22.75   1    62.119  ? 228  VAL A CB    1 ? 
ATOM   1901  C  CG1   . VAL A 1 228 ? -22.52  -15.727 -21.871  1    64.967  ? 228  VAL A CG1   1 ? 
ATOM   1902  C  CG2   . VAL A 1 228 ? -21.665 -16.45  -24.123  1    63.564  ? 228  VAL A CG2   1 ? 
ATOM   1903  N  N     . ARG A 1 229 ? -20.598 -13.349 -20.767  1    79.646  ? 229  ARG A N     1 ? 
ATOM   1904  C  CA    . ARG A 1 229 ? -20.15  -12.744 -19.523  1    85.443  ? 229  ARG A CA    1 ? 
ATOM   1905  C  C     . ARG A 1 229 ? -20.172 -13.797 -18.42   1    87.052  ? 229  ARG A C     1 ? 
ATOM   1906  O  O     . ARG A 1 229 ? -20.866 -14.803 -18.555  1    86.116  ? 229  ARG A O     1 ? 
ATOM   1907  C  CB    . ARG A 1 229 ? -21.042 -11.543 -19.181  1    96.783  ? 229  ARG A CB    1 ? 
ATOM   1908  C  CG    . ARG A 1 229 ? -21.58  -10.744 -20.364  1    109.601 ? 229  ARG A CG    1 ? 
ATOM   1909  C  CD    . ARG A 1 229 ? -20.559 -10.32  -21.421  1    102.529 ? 229  ARG A CD    1 ? 
ATOM   1910  N  NE    . ARG A 1 229 ? -19.454 -9.567  -20.815  1    114.225 ? 229  ARG A NE    1 ? 
ATOM   1911  C  CZ    . ARG A 1 229 ? -19.126 -8.308  -21.081  1    114.407 ? 229  ARG A CZ    1 ? 
ATOM   1912  N  NH1   . ARG A 1 229 ? -19.79  -7.622  -21.996  1    111.746 ? 229  ARG A NH1   1 ? 
ATOM   1913  N  NH2   . ARG A 1 229 ? -18.127 -7.739  -20.43   1    108.371 ? 229  ARG A NH2   1 ? 
ATOM   1914  N  N     . PHE A 1 230 ? -19.389 -13.563 -17.355  1    88.656  ? 230  PHE A N     1 ? 
ATOM   1915  C  CA    . PHE A 1 230 ? -19.36  -14.461 -16.207  1    95.628  ? 230  PHE A CA    1 ? 
ATOM   1916  C  C     . PHE A 1 230 ? -20.425 -14.009 -15.201  1    100.252 ? 230  PHE A C     1 ? 
ATOM   1917  O  O     . PHE A 1 230 ? -20.75  -14.849 -14.334  1    100.581 ? 230  PHE A O     1 ? 
ATOM   1918  C  CB    . PHE A 1 230 ? -18.001 -14.594 -15.504  1    88.16   ? 230  PHE A CB    1 ? 
ATOM   1919  C  CG    . PHE A 1 230 ? -16.794 -14.827 -16.404  1    75.7    ? 230  PHE A CG    1 ? 
ATOM   1920  C  CD1   . PHE A 1 230 ? -16.853 -15.716 -17.475  1    70.195  ? 230  PHE A CD1   1 ? 
ATOM   1921  C  CD2   . PHE A 1 230 ? -15.601 -14.141 -16.181  1    65.645  ? 230  PHE A CD2   1 ? 
ATOM   1922  C  CE1   . PHE A 1 230 ? -15.751 -15.908 -18.294  1    61.672  ? 230  PHE A CE1   1 ? 
ATOM   1923  C  CE2   . PHE A 1 230 ? -14.503 -14.332 -17.004  1    58.323  ? 230  PHE A CE2   1 ? 
ATOM   1924  C  CZ    . PHE A 1 230 ? -14.58  -15.212 -18.059  1    61.998  ? 230  PHE A CZ    1 ? 
ATOM   1925  N  N     . GLU A 1 243 ? -14.678 -24.629 -21.121  1    83.472  ? 243  GLU A N     1 ? 
ATOM   1926  C  CA    . GLU A 1 243 ? -15.377 -24.673 -22.435  1    88.863  ? 243  GLU A CA    1 ? 
ATOM   1927  C  C     . GLU A 1 243 ? -15.679 -23.253 -22.916  1    88.849  ? 243  GLU A C     1 ? 
ATOM   1928  O  O     . GLU A 1 243 ? -16.278 -23.087 -23.98   1    85.955  ? 243  GLU A O     1 ? 
ATOM   1929  C  CB    . GLU A 1 243 ? -16.68  -25.479 -22.369  1    91.896  ? 243  GLU A CB    1 ? 
ATOM   1930  C  CG    . GLU A 1 243 ? -17.823 -24.77  -21.639  1    97.934  ? 243  GLU A CG    1 ? 
ATOM   1931  C  CD    . GLU A 1 243 ? -19.137 -25.519 -21.437  1    105.9   ? 243  GLU A CD    1 ? 
ATOM   1932  O  OE1   . GLU A 1 243 ? -20.123 -24.847 -21.056  1    96.288  ? 243  GLU A OE1   1 ? 
ATOM   1933  O  OE2   . GLU A 1 243 ? -19.195 -26.757 -21.631  1    99.35   ? 243  GLU A OE2   1 ? 
ATOM   1934  N  N     . THR A 1 244 ? -15.271 -22.242 -22.126  1    70.528  ? 244  THR A N     1 ? 
ATOM   1935  C  CA    . THR A 1 244 ? -15.578 -20.846 -22.422  1    59.897  ? 244  THR A CA    1 ? 
ATOM   1936  C  C     . THR A 1 244 ? -14.774 -20.366 -23.635  1    55.727  ? 244  THR A C     1 ? 
ATOM   1937  O  O     . THR A 1 244 ? -13.657 -20.838 -23.871  1    53.173  ? 244  THR A O     1 ? 
ATOM   1938  C  CB    . THR A 1 244 ? -15.384 -19.962 -21.189  1    57.999  ? 244  THR A CB    1 ? 
ATOM   1939  O  OG1   . THR A 1 244 ? -14.109 -20.361 -20.711  1    61.795  ? 244  THR A OG1   1 ? 
ATOM   1940  C  CG2   . THR A 1 244 ? -16.409 -20.222 -20.099  1    55.356  ? 244  THR A CG2   1 ? 
ATOM   1941  N  N     . THR A 1 245 ? -15.39  -19.441 -24.396  1    46.9    ? 245  THR A N     1 ? 
ATOM   1942  C  CA    . THR A 1 245 ? -14.891 -18.871 -25.644  1    42.256  ? 245  THR A CA    1 ? 
ATOM   1943  C  C     . THR A 1 245 ? -14.625 -17.379 -25.441  1    35.707  ? 245  THR A C     1 ? 
ATOM   1944  O  O     . THR A 1 245 ? -15.219 -16.75  -24.564  1    36.766  ? 245  THR A O     1 ? 
ATOM   1945  C  CB    . THR A 1 245 ? -15.932 -19.085 -26.755  1    47.566  ? 245  THR A CB    1 ? 
ATOM   1946  O  OG1   . THR A 1 245 ? -17.182 -18.814 -26.124  1    41.623  ? 245  THR A OG1   1 ? 
ATOM   1947  C  CG2   . THR A 1 245 ? -15.939 -20.486 -27.357  1    46.253  ? 245  THR A CG2   1 ? 
ATOM   1948  N  N     . PHE A 1 246 ? -13.757 -16.811 -26.286  1    33.17   ? 246  PHE A N     1 ? 
ATOM   1949  C  CA    . PHE A 1 246 ? -13.276 -15.451 -26.109  1    38.679  ? 246  PHE A CA    1 ? 
ATOM   1950  C  C     . PHE A 1 246 ? -13.058 -14.799 -27.461  1    36.807  ? 246  PHE A C     1 ? 
ATOM   1951  O  O     . PHE A 1 246 ? -12.533 -15.425 -28.386  1    39.17   ? 246  PHE A O     1 ? 
ATOM   1952  C  CB    . PHE A 1 246 ? -11.886 -15.417 -25.467  1    37.659  ? 246  PHE A CB    1 ? 
ATOM   1953  C  CG    . PHE A 1 246 ? -11.944 -15.858 -24.013  1    46.017  ? 246  PHE A CG    1 ? 
ATOM   1954  C  CD1   . PHE A 1 246 ? -12.077 -17.205 -23.683  1    47.515  ? 246  PHE A CD1   1 ? 
ATOM   1955  C  CD2   . PHE A 1 246 ? -11.91  -14.923 -22.986  1    46.984  ? 246  PHE A CD2   1 ? 
ATOM   1956  C  CE1   . PHE A 1 246 ? -12.164 -17.61  -22.361  1    48.67   ? 246  PHE A CE1   1 ? 
ATOM   1957  C  CE2   . PHE A 1 246 ? -12.005 -15.329 -21.667  1    53.064  ? 246  PHE A CE2   1 ? 
ATOM   1958  C  CZ    . PHE A 1 246 ? -12.125 -16.674 -21.358  1    49.462  ? 246  PHE A CZ    1 ? 
ATOM   1959  N  N     . HIS A 1 247 ? -13.418 -13.517 -27.538  1    32.368  ? 247  HIS A N     1 ? 
ATOM   1960  C  CA    . HIS A 1 247 ? -13.062 -12.721 -28.693  1    29.612  ? 247  HIS A CA    1 ? 
ATOM   1961  C  C     . HIS A 1 247 ? -11.605 -12.363 -28.53   1    34.302  ? 247  HIS A C     1 ? 
ATOM   1962  O  O     . HIS A 1 247 ? -11.193 -11.97  -27.444  1    36.257  ? 247  HIS A O     1 ? 
ATOM   1963  C  CB    . HIS A 1 247 ? -13.864 -11.415 -28.762  1    31.24   ? 247  HIS A CB    1 ? 
ATOM   1964  C  CG    . HIS A 1 247 ? -15.335 -11.607 -28.862  1    32.814  ? 247  HIS A CG    1 ? 
ATOM   1965  N  ND1   . HIS A 1 247 ? -15.937 -11.96  -30.055  1    35.896  ? 247  HIS A ND1   1 ? 
ATOM   1966  C  CD2   . HIS A 1 247 ? -16.313 -11.53  -27.945  1    36.172  ? 247  HIS A CD2   1 ? 
ATOM   1967  C  CE1   . HIS A 1 247 ? -17.251 -12.066 -29.855  1    38.235  ? 247  HIS A CE1   1 ? 
ATOM   1968  N  NE2   . HIS A 1 247 ? -17.5   -11.799 -28.586  1    36.792  ? 247  HIS A NE2   1 ? 
ATOM   1969  N  N     . LEU A 1 248 ? -10.849 -12.51  -29.612  1    32.143  ? 248  LEU A N     1 ? 
ATOM   1970  C  CA    . LEU A 1 248 ? -9.44   -12.216 -29.556  1    32.65   ? 248  LEU A CA    1 ? 
ATOM   1971  C  C     . LEU A 1 248 ? -9.076  -11.402 -30.784  1    36.479  ? 248  LEU A C     1 ? 
ATOM   1972  O  O     . LEU A 1 248 ? -9.267  -11.845 -31.923  1    41.015  ? 248  LEU A O     1 ? 
ATOM   1973  C  CB    . LEU A 1 248 ? -8.721  -13.558 -29.513  1    34.463  ? 248  LEU A CB    1 ? 
ATOM   1974  C  CG    . LEU A 1 248 ? -7.2    -13.456 -29.633  1    36.869  ? 248  LEU A CG    1 ? 
ATOM   1975  C  CD1   . LEU A 1 248 ? -6.628  -12.648 -28.468  1    33.718  ? 248  LEU A CD1   1 ? 
ATOM   1976  C  CD2   . LEU A 1 248 ? -6.619  -14.849 -29.705  1    35.942  ? 248  LEU A CD2   1 ? 
ATOM   1977  N  N     . LEU A 1 249 ? -8.599  -10.183 -30.548  1    27.991  ? 249  LEU A N     1 ? 
ATOM   1978  C  CA    . LEU A 1 249 ? -8.237  -9.346  -31.666  1    30.254  ? 249  LEU A CA    1 ? 
ATOM   1979  C  C     . LEU A 1 249 ? -6.735  -9.093  -31.61   1    35.135  ? 249  LEU A C     1 ? 
ATOM   1980  O  O     . LEU A 1 249 ? -6.241  -8.521  -30.635  1    31.576  ? 249  LEU A O     1 ? 
ATOM   1981  C  CB    . LEU A 1 249 ? -9.073  -8.071  -31.537  1    33.978  ? 249  LEU A CB    1 ? 
ATOM   1982  C  CG    . LEU A 1 249 ? -8.647  -6.874  -32.402  1    41.027  ? 249  LEU A CG    1 ? 
ATOM   1983  C  CD1   . LEU A 1 249 ? -8.784  -7.141  -33.893  1    42.276  ? 249  LEU A CD1   1 ? 
ATOM   1984  C  CD2   . LEU A 1 249 ? -9.368  -5.576  -32.002  1    35.891  ? 249  LEU A CD2   1 ? 
ATOM   1985  N  N     . HIS A 1 250 ? -6.018  -9.485  -32.669  1    33.911  ? 250  HIS A N     1 ? 
ATOM   1986  C  CA    . HIS A 1 250 ? -4.583  -9.279  -32.696  1    36.811  ? 250  HIS A CA    1 ? 
ATOM   1987  C  C     . HIS A 1 250 ? -4.337  -7.998  -33.457  1    38.555  ? 250  HIS A C     1 ? 
ATOM   1988  O  O     . HIS A 1 250 ? -4.661  -7.912  -34.639  1    42.526  ? 250  HIS A O     1 ? 
ATOM   1989  C  CB    . HIS A 1 250 ? -3.802  -10.403 -33.393  1    41.374  ? 250  HIS A CB    1 ? 
ATOM   1990  C  CG    . HIS A 1 250 ? -3.773  -11.692 -32.65   1    42.627  ? 250  HIS A CG    1 ? 
ATOM   1991  N  ND1   . HIS A 1 250 ? -3.212  -11.816 -31.392  1    40.352  ? 250  HIS A ND1   1 ? 
ATOM   1992  C  CD2   . HIS A 1 250 ? -4.285  -12.897 -32.954  1    41.519  ? 250  HIS A CD2   1 ? 
ATOM   1993  C  CE1   . HIS A 1 250 ? -3.377  -13.057 -30.952  1    39.983  ? 250  HIS A CE1   1 ? 
ATOM   1994  N  NE2   . HIS A 1 250 ? -4.011  -13.733 -31.886  1    43.102  ? 250  HIS A NE2   1 ? 
ATOM   1995  N  N     . LEU A 1 251 ? -3.747  -7.014  -32.781  1    35.729  ? 251  LEU A N     1 ? 
ATOM   1996  C  CA    . LEU A 1 251 ? -3.43   -5.776  -33.474  1    36.506  ? 251  LEU A CA    1 ? 
ATOM   1997  C  C     . LEU A 1 251 ? -2.276  -5.943  -34.47   1    34.575  ? 251  LEU A C     1 ? 
ATOM   1998  O  O     . LEU A 1 251 ? -2.163  -5.14   -35.388  1    31.495  ? 251  LEU A O     1 ? 
ATOM   1999  C  CB    . LEU A 1 251 ? -3.206  -4.636  -32.487  1    33.778  ? 251  LEU A CB    1 ? 
ATOM   2000  C  CG    . LEU A 1 251 ? -4.44   -4.272  -31.649  1    30.96   ? 251  LEU A CG    1 ? 
ATOM   2001  C  CD1   . LEU A 1 251 ? -4.057  -2.974  -30.977  1    29.741  ? 251  LEU A CD1   1 ? 
ATOM   2002  C  CD2   . LEU A 1 251 ? -5.703  -4.065  -32.484  1    25.484  ? 251  LEU A CD2   1 ? 
ATOM   2003  N  N     . SER A 1 252 ? -1.416  -6.963  -34.312  1    36.384  ? 252  SER A N     1 ? 
ATOM   2004  C  CA    . SER A 1 252 ? -0.421  -7.206  -35.354  1    41.974  ? 252  SER A CA    1 ? 
ATOM   2005  C  C     . SER A 1 252 ? -1.11   -7.393  -36.711  1    43.447  ? 252  SER A C     1 ? 
ATOM   2006  O  O     . SER A 1 252 ? -0.632  -6.885  -37.726  1    42.081  ? 252  SER A O     1 ? 
ATOM   2007  C  CB    . SER A 1 252 ? 0.459   -8.392  -35.046  1    42.36   ? 252  SER A CB    1 ? 
ATOM   2008  O  OG    . SER A 1 252 ? -0.368  -9.531  -34.851  1    38.948  ? 252  SER A OG    1 ? 
ATOM   2009  N  N     . LEU A 1 253 ? -2.226  -8.134  -36.703  1    38.083  ? 253  LEU A N     1 ? 
ATOM   2010  C  CA    . LEU A 1 253 ? -2.999  -8.44   -37.891  1    46.794  ? 253  LEU A CA    1 ? 
ATOM   2011  C  C     . LEU A 1 253 ? -3.688  -7.178  -38.404  1    49.859  ? 253  LEU A C     1 ? 
ATOM   2012  O  O     . LEU A 1 253 ? -3.62   -6.868  -39.599  1    46.702  ? 253  LEU A O     1 ? 
ATOM   2013  C  CB    . LEU A 1 253 ? -3.975  -9.581  -37.605  1    44.703  ? 253  LEU A CB    1 ? 
ATOM   2014  C  CG    . LEU A 1 253 ? -3.311  -10.944 -37.378  1    56.454  ? 253  LEU A CG    1 ? 
ATOM   2015  C  CD1   . LEU A 1 253 ? -4.305  -12.104 -37.343  1    54.196  ? 253  LEU A CD1   1 ? 
ATOM   2016  C  CD2   . LEU A 1 253 ? -2.2    -11.216 -38.387  1    58.668  ? 253  LEU A CD2   1 ? 
ATOM   2017  N  N     . MET A 1 254 ? -4.318  -6.437  -37.48   1    47.084  ? 254  MET A N     1 ? 
ATOM   2018  C  CA    . MET A 1 254 ? -4.956  -5.18   -37.837  1    41.083  ? 254  MET A CA    1 ? 
ATOM   2019  C  C     . MET A 1 254 ? -3.973  -4.248  -38.533  1    37.197  ? 254  MET A C     1 ? 
ATOM   2020  O  O     . MET A 1 254 ? -4.335  -3.65   -39.546  1    38.623  ? 254  MET A O     1 ? 
ATOM   2021  C  CB    . MET A 1 254 ? -5.649  -4.514  -36.645  1    41.634  ? 254  MET A CB    1 ? 
ATOM   2022  C  CG    . MET A 1 254 ? -6.424  -3.262  -37.006  1    40.549  ? 254  MET A CG    1 ? 
ATOM   2023  S  SD    . MET A 1 254 ? -7.599  -3.003  -35.67   1    50.557  ? 254  MET A SD    1 ? 
ATOM   2024  C  CE    . MET A 1 254 ? -8.524  -1.583  -36.271  1    42.172  ? 254  MET A CE    1 ? 
ATOM   2025  N  N     . ARG A 1 255 ? -2.74   -4.134  -38.003  1    34.524  ? 255  ARG A N     1 ? 
ATOM   2026  C  CA    . ARG A 1 255 ? -1.73   -3.284  -38.619  1    37.045  ? 255  ARG A CA    1 ? 
ATOM   2027  C  C     . ARG A 1 255 ? -1.512  -3.698  -40.083  1    42.544  ? 255  ARG A C     1 ? 
ATOM   2028  O  O     . ARG A 1 255 ? -1.588  -2.855  -40.97   1    39.008  ? 255  ARG A O     1 ? 
ATOM   2029  C  CB    . ARG A 1 255 ? -0.417  -3.237  -37.826  1    39.642  ? 255  ARG A CB    1 ? 
ATOM   2030  C  CG    . ARG A 1 255 ? -0.527  -2.444  -36.527  1    43.926  ? 255  ARG A CG    1 ? 
ATOM   2031  C  CD    . ARG A 1 255 ? 0.443   -2.951  -35.476  1    41.353  ? 255  ARG A CD    1 ? 
ATOM   2032  N  NE    . ARG A 1 255 ? 1.809   -2.944  -36.009  1    39.479  ? 255  ARG A NE    1 ? 
ATOM   2033  C  CZ    . ARG A 1 255 ? 2.534   -1.881  -36.311  1    39.511  ? 255  ARG A CZ    1 ? 
ATOM   2034  N  NH1   . ARG A 1 255 ? 2.162   -0.674  -35.927  1    40.95   ? 255  ARG A NH1   1 ? 
ATOM   2035  N  NH2   . ARG A 1 255 ? 3.675   -2.03   -36.962  1    42.903  ? 255  ARG A NH2   1 ? 
ATOM   2036  N  N     . GLU A 1 256 ? -1.275  -4.996  -40.334  1    46.297  ? 256  GLU A N     1 ? 
ATOM   2037  C  CA    . GLU A 1 256 ? -1.061  -5.511  -41.682  1    51.465  ? 256  GLU A CA    1 ? 
ATOM   2038  C  C     . GLU A 1 256 ? -2.214  -5.109  -42.602  1    51.329  ? 256  GLU A C     1 ? 
ATOM   2039  O  O     . GLU A 1 256 ? -1.972  -4.582  -43.696  1    42.13   ? 256  GLU A O     1 ? 
ATOM   2040  C  CB    . GLU A 1 256 ? -0.842  -7.023  -41.727  1    56.221  ? 256  GLU A CB    1 ? 
ATOM   2041  C  CG    . GLU A 1 256 ? 0.53    -7.45   -41.215  1    66.375  ? 256  GLU A CG    1 ? 
ATOM   2042  C  CD    . GLU A 1 256 ? 0.774   -8.948  -41.328  1    84.729  ? 256  GLU A CD    1 ? 
ATOM   2043  O  OE1   . GLU A 1 256 ? 0.83    -9.479  -42.466  1    91.31   ? 256  GLU A OE1   1 ? 
ATOM   2044  O  OE2   . GLU A 1 256 ? 0.904   -9.592  -40.261  1    86.228  ? 256  GLU A OE2   1 ? 
ATOM   2045  N  N     . TYR A 1 257 ? -3.451  -5.371  -42.141  1    48.722  ? 257  TYR A N     1 ? 
ATOM   2046  C  CA    . TYR A 1 257 ? -4.666  -5.082  -42.886  1    50.19   ? 257  TYR A CA    1 ? 
ATOM   2047  C  C     . TYR A 1 257 ? -4.672  -3.627  -43.331  1    52.941  ? 257  TYR A C     1 ? 
ATOM   2048  O  O     . TYR A 1 257 ? -4.939  -3.33   -44.492  1    55.145  ? 257  TYR A O     1 ? 
ATOM   2049  C  CB    . TYR A 1 257 ? -5.929  -5.347  -42.068  1    47.653  ? 257  TYR A CB    1 ? 
ATOM   2050  C  CG    . TYR A 1 257 ? -6.626  -6.67   -42.336  1    50.69   ? 257  TYR A CG    1 ? 
ATOM   2051  C  CD1   . TYR A 1 257 ? -7.538  -6.804  -43.379  1    65.53   ? 257  TYR A CD1   1 ? 
ATOM   2052  C  CD2   . TYR A 1 257 ? -6.396  -7.779  -41.537  1    54.51   ? 257  TYR A CD2   1 ? 
ATOM   2053  C  CE1   . TYR A 1 257 ? -8.207  -7.999  -43.608  1    65.266  ? 257  TYR A CE1   1 ? 
ATOM   2054  C  CE2   . TYR A 1 257 ? -7.039  -8.983  -41.767  1    60.871  ? 257  TYR A CE2   1 ? 
ATOM   2055  C  CZ    . TYR A 1 257 ? -7.951  -9.096  -42.802  1    66.233  ? 257  TYR A CZ    1 ? 
ATOM   2056  O  OH    . TYR A 1 257 ? -8.594  -10.285 -43.008  1    69.156  ? 257  TYR A OH    1 ? 
ATOM   2057  N  N     . ILE A 1 258 ? -4.363  -2.729  -42.394  1    51.799  ? 258  ILE A N     1 ? 
ATOM   2058  C  CA    . ILE A 1 258 ? -4.353  -1.306  -42.687  1    47.994  ? 258  ILE A CA    1 ? 
ATOM   2059  C  C     . ILE A 1 258 ? -3.204  -1.007  -43.65   1    46.257  ? 258  ILE A C     1 ? 
ATOM   2060  O  O     . ILE A 1 258 ? -3.332  -0.14   -44.515  1    45.583  ? 258  ILE A O     1 ? 
ATOM   2061  C  CB    . ILE A 1 258 ? -4.265  -0.464  -41.395  1    44.861  ? 258  ILE A CB    1 ? 
ATOM   2062  C  CG1   . ILE A 1 258 ? -5.474  -0.661  -40.487  1    48.246  ? 258  ILE A CG1   1 ? 
ATOM   2063  C  CG2   . ILE A 1 258 ? -4.033  1.026   -41.692  1    42.465  ? 258  ILE A CG2   1 ? 
ATOM   2064  C  CD1   . ILE A 1 258 ? -5.291  0.001   -39.131  1    38.209  ? 258  ILE A CD1   1 ? 
ATOM   2065  N  N     . ASP A 1 259 ? -2.074  -1.701  -43.48   1    46.053  ? 259  ASP A N     1 ? 
ATOM   2066  C  CA    . ASP A 1 259 ? -0.928  -1.467  -44.343  1    50.108  ? 259  ASP A CA    1 ? 
ATOM   2067  C  C     . ASP A 1 259 ? -1.353  -1.707  -45.785  1    58.541  ? 259  ASP A C     1 ? 
ATOM   2068  O  O     . ASP A 1 259 ? -0.983  -0.948  -46.676  1    63.558  ? 259  ASP A O     1 ? 
ATOM   2069  C  CB    . ASP A 1 259 ? 0.293   -2.276  -43.936  1    46.202  ? 259  ASP A CB    1 ? 
ATOM   2070  C  CG    . ASP A 1 259 ? 1.603   -1.846  -44.579  1    48.792  ? 259  ASP A CG    1 ? 
ATOM   2071  O  OD1   . ASP A 1 259 ? 1.63    -0.78   -45.243  1    48.999  ? 259  ASP A OD1   1 ? 
ATOM   2072  O  OD2   . ASP A 1 259 ? 2.594   -2.577  -44.405  1    52.956  ? 259  ASP A OD2   1 ? 
ATOM   2073  N  N     . TYR A 1 260 ? -2.183  -2.734  -45.981  1    68.472  ? 260  TYR A N     1 ? 
ATOM   2074  C  CA    . TYR A 1 260 ? -2.667  -3.068  -47.306  1    76.714  ? 260  TYR A CA    1 ? 
ATOM   2075  C  C     . TYR A 1 260 ? -3.665  -2.009  -47.764  1    78.606  ? 260  TYR A C     1 ? 
ATOM   2076  O  O     . TYR A 1 260 ? -3.456  -1.402  -48.812  1    90.795  ? 260  TYR A O     1 ? 
ATOM   2077  C  CB    . TYR A 1 260 ? -3.258  -4.476  -47.356  1    83.71   ? 260  TYR A CB    1 ? 
ATOM   2078  C  CG    . TYR A 1 260 ? -3.315  -5.03   -48.774  1    111.825 ? 260  TYR A CG    1 ? 
ATOM   2079  C  CD1   . TYR A 1 260 ? -2.204  -5.641  -49.351  1    118.698 ? 260  TYR A CD1   1 ? 
ATOM   2080  C  CD2   . TYR A 1 260 ? -4.475  -4.938  -49.541  1    114.664 ? 260  TYR A CD2   1 ? 
ATOM   2081  C  CE1   . TYR A 1 260 ? -2.244  -6.151  -50.641  1    120.229 ? 260  TYR A CE1   1 ? 
ATOM   2082  C  CE2   . TYR A 1 260 ? -4.524  -5.442  -50.834  1    120.69  ? 260  TYR A CE2   1 ? 
ATOM   2083  C  CZ    . TYR A 1 260 ? -3.408  -6.055  -51.384  1    121.28  ? 260  TYR A CZ    1 ? 
ATOM   2084  O  OH    . TYR A 1 260 ? -3.435  -6.566  -52.652  1    113.01  ? 260  TYR A OH    1 ? 
ATOM   2085  N  N     . GLU A 1 261 ? -4.726  -1.793  -46.964  1    74.687  ? 261  GLU A N     1 ? 
ATOM   2086  C  CA    . GLU A 1 261 ? -5.848  -0.913  -47.286  1    68.101  ? 261  GLU A CA    1 ? 
ATOM   2087  C  C     . GLU A 1 261 ? -5.34   0.382   -47.923  1    64.279  ? 261  GLU A C     1 ? 
ATOM   2088  O  O     . GLU A 1 261 ? -6.056  0.987   -48.717  1    68.089  ? 261  GLU A O     1 ? 
ATOM   2089  C  CB    . GLU A 1 261 ? -6.755  -0.667  -46.071  1    78.714  ? 261  GLU A CB    1 ? 
ATOM   2090  C  CG    . GLU A 1 261 ? -8.081  0.049   -46.347  1    84.177  ? 261  GLU A CG    1 ? 
ATOM   2091  C  CD    . GLU A 1 261 ? -9.167  -0.016  -45.269  1    92.741  ? 261  GLU A CD    1 ? 
ATOM   2092  O  OE1   . GLU A 1 261 ? -9.019  0.587   -44.179  1    96.592  ? 261  GLU A OE1   1 ? 
ATOM   2093  O  OE2   . GLU A 1 261 ? -10.194 -0.691  -45.517  1    100.105 ? 261  GLU A OE2   1 ? 
ATOM   2094  N  N     . PHE A 1 262 ? -4.086  0.755   -47.623  1    52.566  ? 262  PHE A N     1 ? 
ATOM   2095  C  CA    . PHE A 1 262 ? -3.564  2.08    -47.935  1    56.312  ? 262  PHE A CA    1 ? 
ATOM   2096  C  C     . PHE A 1 262 ? -2.298  2.014   -48.794  1    53.881  ? 262  PHE A C     1 ? 
ATOM   2097  O  O     . PHE A 1 262 ? -1.73   3.061   -49.12   1    50.804  ? 262  PHE A O     1 ? 
ATOM   2098  C  CB    . PHE A 1 262 ? -3.369  2.924   -46.657  1    52.086  ? 262  PHE A CB    1 ? 
ATOM   2099  C  CG    . PHE A 1 262 ? -4.676  3.302   -45.967  1    47.412  ? 262  PHE A CG    1 ? 
ATOM   2100  C  CD1   . PHE A 1 262 ? -5.352  4.476   -46.296  1    50.023  ? 262  PHE A CD1   1 ? 
ATOM   2101  C  CD2   . PHE A 1 262 ? -5.258  2.454   -45.031  1    49.135  ? 262  PHE A CD2   1 ? 
ATOM   2102  C  CE1   . PHE A 1 262 ? -6.577  4.784   -45.713  1    49.923  ? 262  PHE A CE1   1 ? 
ATOM   2103  C  CE2   . PHE A 1 262 ? -6.478  2.77    -44.441  1    48.588  ? 262  PHE A CE2   1 ? 
ATOM   2104  C  CZ    . PHE A 1 262 ? -7.131  3.935   -44.779  1    48.427  ? 262  PHE A CZ    1 ? 
ATOM   2105  N  N     . SER A 1 263 ? -1.843  0.803   -49.154  1    55.358  ? 263  SER A N     1 ? 
ATOM   2106  C  CA    A SER A 1 263 ? -0.596  0.678   -49.899  0.5  58.359  ? 263  SER A CA    1 ? 
ATOM   2107  C  CA    B SER A 1 263 ? -0.612  0.631   -49.916  0.5  55.992  ? 263  SER A CA    1 ? 
ATOM   2108  C  C     . SER A 1 263 ? -0.709  1.304   -51.288  1    50.906  ? 263  SER A C     1 ? 
ATOM   2109  O  O     . SER A 1 263 ? 0.287   1.796   -51.811  1    51.718  ? 263  SER A O     1 ? 
ATOM   2110  C  CB    A SER A 1 263 ? -0.055  -0.731  -49.94   0.5  56.742  ? 263  SER A CB    1 ? 
ATOM   2111  C  CB    B SER A 1 263 ? -0.201  -0.828  -50.005  0.5  50.18   ? 263  SER A CB    1 ? 
ATOM   2112  O  OG    A SER A 1 263 ? 0.946   -0.898  -48.945  0.5  57.915  ? 263  SER A OG    1 ? 
ATOM   2113  O  OG    B SER A 1 263 ? -1.329  -1.694  -49.996  0.5  44.828  ? 263  SER A OG    1 ? 
ATOM   2114  N  N     . VAL A 1 264 ? -1.932  1.343   -51.833  1    52.967  ? 264  VAL A N     1 ? 
ATOM   2115  C  CA    . VAL A 1 264 ? -2.231  2.029   -53.083  1    57.717  ? 264  VAL A CA    1 ? 
ATOM   2116  C  C     . VAL A 1 264 ? -1.589  3.409   -53.08   1    63.773  ? 264  VAL A C     1 ? 
ATOM   2117  O  O     . VAL A 1 264 ? -1.277  3.933   -54.144  1    77.847  ? 264  VAL A O     1 ? 
ATOM   2118  C  CB    . VAL A 1 264 ? -3.719  2.171   -53.45   1    52.893  ? 264  VAL A CB    1 ? 
ATOM   2119  C  CG1   . VAL A 1 264 ? -4.347  0.843   -53.841  1    54.356  ? 264  VAL A CG1   1 ? 
ATOM   2120  C  CG2   . VAL A 1 264 ? -4.515  2.868   -52.357  1    55.074  ? 264  VAL A CG2   1 ? 
ATOM   2121  N  N     . LEU A 1 265 ? -1.4    3.993   -51.891  1    60.145  ? 265  LEU A N     1 ? 
ATOM   2122  C  CA    . LEU A 1 265 ? -0.882  5.352   -51.81   1    60.113  ? 265  LEU A CA    1 ? 
ATOM   2123  C  C     . LEU A 1 265 ? 0.611   5.352   -52.125  1    62.786  ? 265  LEU A C     1 ? 
ATOM   2124  O  O     . LEU A 1 265 ? 1.15    6.402   -52.468  1    68.158  ? 265  LEU A O     1 ? 
ATOM   2125  C  CB    . LEU A 1 265 ? -1.199  6.056   -50.484  1    60.446  ? 265  LEU A CB    1 ? 
ATOM   2126  C  CG    . LEU A 1 265 ? -2.689  6.282   -50.175  1    67.246  ? 265  LEU A CG    1 ? 
ATOM   2127  C  CD1   . LEU A 1 265 ? -2.956  6.998   -48.86   1    62.336  ? 265  LEU A CD1   1 ? 
ATOM   2128  C  CD2   . LEU A 1 265 ? -3.439  6.996   -51.296  1    67.182  ? 265  LEU A CD2   1 ? 
ATOM   2129  N  N     . LYS A 1 266 ? 1.252   4.169   -52.053  1    70.019  ? 266  LYS A N     1 ? 
ATOM   2130  C  CA    . LYS A 1 266 ? 2.707   4.033   -52.045  1    78.376  ? 266  LYS A CA    1 ? 
ATOM   2131  C  C     . LYS A 1 266 ? 3.363   4.802   -53.191  1    85.637  ? 266  LYS A C     1 ? 
ATOM   2132  O  O     . LYS A 1 266 ? 4.461   5.33    -53.022  1    92.192  ? 266  LYS A O     1 ? 
ATOM   2133  C  CB    . LYS A 1 266 ? 3.223   2.588   -52.026  1    80.611  ? 266  LYS A CB    1 ? 
ATOM   2134  C  CG    . LYS A 1 266 ? 3.598   2.068   -50.644  1    92.164  ? 266  LYS A CG    1 ? 
ATOM   2135  C  CD    . LYS A 1 266 ? 4.703   1.014   -50.589  1    90.354  ? 266  LYS A CD    1 ? 
ATOM   2136  C  CE    . LYS A 1 266 ? 4.263   -0.418  -50.595  1    88.16   ? 266  LYS A CE    1 ? 
ATOM   2137  N  NZ    . LYS A 1 266 ? 3.772   -0.848  -49.284  1    86.824  ? 266  LYS A NZ    1 ? 
ATOM   2138  N  N     . GLU A 1 267 ? 2.674   4.871   -54.338  1    86.051  ? 267  GLU A N     1 ? 
ATOM   2139  C  CA    . GLU A 1 267 ? 3.217   5.433   -55.565  1    92.045  ? 267  GLU A CA    1 ? 
ATOM   2140  C  C     . GLU A 1 267 ? 2.735   6.868   -55.777  1    94.557  ? 267  GLU A C     1 ? 
ATOM   2141  O  O     . GLU A 1 267 ? 3.423   7.671   -56.404  1    94.03   ? 267  GLU A O     1 ? 
ATOM   2142  C  CB    . GLU A 1 267 ? 2.784   4.533   -56.722  1    98.68   ? 267  GLU A CB    1 ? 
ATOM   2143  C  CG    . GLU A 1 267 ? 1.268   4.398   -56.851  1    102.749 ? 267  GLU A CG    1 ? 
ATOM   2144  C  CD    . GLU A 1 267 ? 0.835   3.07    -57.443  1    112.498 ? 267  GLU A CD    1 ? 
ATOM   2145  O  OE1   . GLU A 1 267 ? 1.251   2.749   -58.578  1    110.042 ? 267  GLU A OE1   1 ? 
ATOM   2146  O  OE2   . GLU A 1 267 ? 0.083   2.349   -56.752  1    117.503 ? 267  GLU A OE2   1 ? 
ATOM   2147  N  N     . LYS A 1 268 ? 1.549   7.182   -55.243  1    89.087  ? 268  LYS A N     1 ? 
ATOM   2148  C  CA    . LYS A 1 268 ? 0.844   8.414   -55.56   1    76.187  ? 268  LYS A CA    1 ? 
ATOM   2149  C  C     . LYS A 1 268 ? 1.43    9.604   -54.793  1    75.733  ? 268  LYS A C     1 ? 
ATOM   2150  O  O     . LYS A 1 268 ? 1.143   10.748  -55.144  1    72.245  ? 268  LYS A O     1 ? 
ATOM   2151  C  CB    . LYS A 1 268 ? -0.643  8.208   -55.244  1    75.072  ? 268  LYS A CB    1 ? 
ATOM   2152  C  CG    . LYS A 1 268 ? -1.306  6.966   -55.839  1    75.088  ? 268  LYS A CG    1 ? 
ATOM   2153  C  CD    . LYS A 1 268 ? -2.367  7.192   -56.909  1    82.273  ? 268  LYS A CD    1 ? 
ATOM   2154  C  CE    . LYS A 1 268 ? -1.897  7.854   -58.164  1    91.812  ? 268  LYS A CE    1 ? 
ATOM   2155  N  NZ    . LYS A 1 268 ? -3.028  8.171   -59.039  1    86.894  ? 268  LYS A NZ    1 ? 
ATOM   2156  N  N     . ILE A 1 269 ? 2.257   9.345   -53.766  1    72.331  ? 269  ILE A N     1 ? 
ATOM   2157  C  CA    . ILE A 1 269 ? 2.624   10.369  -52.79   1    67.342  ? 269  ILE A CA    1 ? 
ATOM   2158  C  C     . ILE A 1 269 ? 4.066   10.848  -52.975  1    68.636  ? 269  ILE A C     1 ? 
ATOM   2159  O  O     . ILE A 1 269 ? 4.94    10.1    -53.413  1    64.013  ? 269  ILE A O     1 ? 
ATOM   2160  C  CB    . ILE A 1 269 ? 2.335   9.928   -51.34   1    63.841  ? 269  ILE A CB    1 ? 
ATOM   2161  C  CG1   . ILE A 1 269 ? 3.141   8.663   -50.95   1    58.496  ? 269  ILE A CG1   1 ? 
ATOM   2162  C  CG2   . ILE A 1 269 ? 0.827   9.765   -51.116  1    57.551  ? 269  ILE A CG2   1 ? 
ATOM   2163  C  CD1   . ILE A 1 269 ? 3.106   8.279   -49.477  1    47.065  ? 269  ILE A CD1   1 ? 
ATOM   2164  N  N     . THR A 1 270 ? 4.288   12.108  -52.574  1    64.578  ? 270  THR A N     1 ? 
ATOM   2165  C  CA    . THR A 1 270 ? 5.503   12.883  -52.77   1    69.858  ? 270  THR A CA    1 ? 
ATOM   2166  C  C     . THR A 1 270 ? 6.547   12.491  -51.733  1    73.663  ? 270  THR A C     1 ? 
ATOM   2167  O  O     . THR A 1 270 ? 7.734   12.784  -51.886  1    77.225  ? 270  THR A O     1 ? 
ATOM   2168  C  CB    . THR A 1 270 ? 5.106   14.346  -52.581  1    77.069  ? 270  THR A CB    1 ? 
ATOM   2169  O  OG1   . THR A 1 270 ? 4.209   14.564  -53.663  1    83.098  ? 270  THR A OG1   1 ? 
ATOM   2170  C  CG2   . THR A 1 270 ? 6.282   15.308  -52.604  1    77.474  ? 270  THR A CG2   1 ? 
ATOM   2171  N  N     . PHE A 1 271 ? 6.065   11.866  -50.655  1    74.964  ? 271  PHE A N     1 ? 
ATOM   2172  C  CA    . PHE A 1 271 ? 6.844   11.654  -49.446  1    66.848  ? 271  PHE A CA    1 ? 
ATOM   2173  C  C     . PHE A 1 271 ? 6.835   10.162  -49.136  1    60.419  ? 271  PHE A C     1 ? 
ATOM   2174  O  O     . PHE A 1 271 ? 6.057   9.402   -49.73   1    54.078  ? 271  PHE A O     1 ? 
ATOM   2175  C  CB    . PHE A 1 271 ? 6.296   12.556  -48.328  1    68.193  ? 271  PHE A CB    1 ? 
ATOM   2176  C  CG    . PHE A 1 271 ? 4.785   12.453  -48.14   1    56.978  ? 271  PHE A CG    1 ? 
ATOM   2177  C  CD1   . PHE A 1 271 ? 3.918   13.253  -48.874  1    59.995  ? 271  PHE A CD1   1 ? 
ATOM   2178  C  CD2   . PHE A 1 271 ? 4.233   11.513  -47.277  1    59.672  ? 271  PHE A CD2   1 ? 
ATOM   2179  C  CE1   . PHE A 1 271 ? 2.542   13.132  -48.731  1    57.499  ? 271  PHE A CE1   1 ? 
ATOM   2180  C  CE2   . PHE A 1 271 ? 2.858   11.392  -47.143  1    55.343  ? 271  PHE A CE2   1 ? 
ATOM   2181  C  CZ    . PHE A 1 271 ? 2.019   12.212  -47.857  1    53.095  ? 271  PHE A CZ    1 ? 
ATOM   2182  N  N     . LYS A 1 272 ? 7.728   9.786   -48.207  1    65.334  ? 272  LYS A N     1 ? 
ATOM   2183  C  CA    . LYS A 1 272 ? 7.941   8.425   -47.738  1    67.95   ? 272  LYS A CA    1 ? 
ATOM   2184  C  C     . LYS A 1 272 ? 6.647   7.831   -47.174  1    67.917  ? 272  LYS A C     1 ? 
ATOM   2185  O  O     . LYS A 1 272 ? 6.01    8.396   -46.28   1    67.406  ? 272  LYS A O     1 ? 
ATOM   2186  C  CB    . LYS A 1 272 ? 9.072   8.466   -46.701  1    76.704  ? 272  LYS A CB    1 ? 
ATOM   2187  C  CG    . LYS A 1 272 ? 9.428   7.137   -46.038  1    94.156  ? 272  LYS A CG    1 ? 
ATOM   2188  C  CD    . LYS A 1 272 ? 9.946   6.052   -46.979  1    101.021 ? 272  LYS A CD    1 ? 
ATOM   2189  C  CE    . LYS A 1 272 ? 10.298  4.792   -46.246  1    108.033 ? 272  LYS A CE    1 ? 
ATOM   2190  N  NZ    . LYS A 1 272 ? 10.973  3.819   -47.108  1    109.705 ? 272  LYS A NZ    1 ? 
ATOM   2191  N  N     . TYR A 1 273 ? 6.257   6.683   -47.726  1    56.266  ? 273  TYR A N     1 ? 
ATOM   2192  C  CA    . TYR A 1 273 ? 5.17    5.904   -47.166  1    56.576  ? 273  TYR A CA    1 ? 
ATOM   2193  C  C     . TYR A 1 273 ? 5.711   5.091   -45.996  1    58.645  ? 273  TYR A C     1 ? 
ATOM   2194  O  O     . TYR A 1 273 ? 6.683   4.349   -46.149  1    58.235  ? 273  TYR A O     1 ? 
ATOM   2195  C  CB    . TYR A 1 273 ? 4.625   4.907   -48.186  1    50.985  ? 273  TYR A CB    1 ? 
ATOM   2196  C  CG    . TYR A 1 273 ? 3.524   3.983   -47.684  1    47.246  ? 273  TYR A CG    1 ? 
ATOM   2197  C  CD1   . TYR A 1 273 ? 3.812   2.792   -47.023  1    47.332  ? 273  TYR A CD1   1 ? 
ATOM   2198  C  CD2   . TYR A 1 273 ? 2.186   4.3     -47.891  1    48.367  ? 273  TYR A CD2   1 ? 
ATOM   2199  C  CE1   . TYR A 1 273 ? 2.792   1.941   -46.605  1    48.456  ? 273  TYR A CE1   1 ? 
ATOM   2200  C  CE2   . TYR A 1 273 ? 1.16    3.464   -47.469  1    46.693  ? 273  TYR A CE2   1 ? 
ATOM   2201  C  CZ    . TYR A 1 273 ? 1.462   2.282   -46.819  1    44.546  ? 273  TYR A CZ    1 ? 
ATOM   2202  O  OH    . TYR A 1 273 ? 0.428   1.479   -46.412  1    44.703  ? 273  TYR A OH    1 ? 
ATOM   2203  N  N     . ASP A 1 274 ? 5.024   5.211   -44.849  1    59.872  ? 274  ASP A N     1 ? 
ATOM   2204  C  CA    . ASP A 1 274 ? 5.449   4.617   -43.588  1    50.317  ? 274  ASP A CA    1 ? 
ATOM   2205  C  C     . ASP A 1 274 ? 4.213   4.127   -42.842  1    46.834  ? 274  ASP A C     1 ? 
ATOM   2206  O  O     . ASP A 1 274 ? 3.362   4.924   -42.45   1    42.868  ? 274  ASP A O     1 ? 
ATOM   2207  C  CB    . ASP A 1 274 ? 6.341   5.586   -42.827  1    51.672  ? 274  ASP A CB    1 ? 
ATOM   2208  C  CG    . ASP A 1 274 ? 6.953   5.064   -41.537  1    63.275  ? 274  ASP A CG    1 ? 
ATOM   2209  O  OD1   . ASP A 1 274 ? 6.537   3.974   -41.084  1    63.494  ? 274  ASP A OD1   1 ? 
ATOM   2210  O  OD2   . ASP A 1 274 ? 7.837   5.76    -40.991  1    70.188  ? 274  ASP A OD2   1 ? 
ATOM   2211  N  N     . ILE A 1 275 ? 4.123   2.81    -42.652  1    44.946  ? 275  ILE A N     1 ? 
ATOM   2212  C  CA    . ILE A 1 275 ? 2.955   2.184   -42.042  1    48.709  ? 275  ILE A CA    1 ? 
ATOM   2213  C  C     . ILE A 1 275 ? 2.615   2.847   -40.701  1    46.151  ? 275  ILE A C     1 ? 
ATOM   2214  O  O     . ILE A 1 275 ? 1.441   2.992   -40.377  1    40.367  ? 275  ILE A O     1 ? 
ATOM   2215  C  CB    . ILE A 1 275 ? 3.14    0.661   -41.893  1    47.862  ? 275  ILE A CB    1 ? 
ATOM   2216  C  CG1   . ILE A 1 275 ? 1.899   -0.002  -41.297  1    46.884  ? 275  ILE A CG1   1 ? 
ATOM   2217  C  CG2   . ILE A 1 275 ? 4.395   0.331   -41.078  1    51.348  ? 275  ILE A CG2   1 ? 
ATOM   2218  C  CD1   . ILE A 1 275 ? 0.594   0.521   -41.872  1    49.867  ? 275  ILE A CD1   1 ? 
ATOM   2219  N  N     . GLU A 1 276 ? 3.646   3.243   -39.939  1    44.662  ? 276  GLU A N     1 ? 
ATOM   2220  C  CA    . GLU A 1 276 ? 3.465   3.833   -38.623  1    46.303  ? 276  GLU A CA    1 ? 
ATOM   2221  C  C     . GLU A 1 276 ? 2.695   5.145   -38.766  1    50.775  ? 276  GLU A C     1 ? 
ATOM   2222  O  O     . GLU A 1 276 ? 1.727   5.378   -38.039  1    51.762  ? 276  GLU A O     1 ? 
ATOM   2223  C  CB    . GLU A 1 276 ? 4.771   3.968   -37.833  1    46.3    ? 276  GLU A CB    1 ? 
ATOM   2224  C  CG    . GLU A 1 276 ? 5.546   2.657   -37.701  1    46.733  ? 276  GLU A CG    1 ? 
ATOM   2225  C  CD    . GLU A 1 276 ? 4.873   1.464   -37.03   1    50.121  ? 276  GLU A CD    1 ? 
ATOM   2226  O  OE1   . GLU A 1 276 ? 3.754   1.529   -36.456  1    49.073  ? 276  GLU A OE1   1 ? 
ATOM   2227  O  OE2   . GLU A 1 276 ? 5.519   0.406   -37.086  1    51.996  ? 276  GLU A OE2   1 ? 
ATOM   2228  N  N     . ARG A 1 277 ? 3.112   5.97    -39.73   1    40.434  ? 277  ARG A N     1 ? 
ATOM   2229  C  CA    . ARG A 1 277 ? 2.447   7.232   -40.008  1    40.831  ? 277  ARG A CA    1 ? 
ATOM   2230  C  C     . ARG A 1 277 ? 1.015   7.021   -40.501  1    43.383  ? 277  ARG A C     1 ? 
ATOM   2231  O  O     . ARG A 1 277 ? 0.161   7.854   -40.212  1    50.328  ? 277  ARG A O     1 ? 
ATOM   2232  C  CB    . ARG A 1 277 ? 3.225   8.089   -41.006  1    44.183  ? 277  ARG A CB    1 ? 
ATOM   2233  C  CG    . ARG A 1 277 ? 4.711   8.24    -40.724  1    49.571  ? 277  ARG A CG    1 ? 
ATOM   2234  C  CD    . ARG A 1 277 ? 5.034   8.968   -39.443  1    57.501  ? 277  ARG A CD    1 ? 
ATOM   2235  N  NE    . ARG A 1 277 ? 6.416   9.448   -39.53   1    70.821  ? 277  ARG A NE    1 ? 
ATOM   2236  C  CZ    . ARG A 1 277 ? 6.78    10.503  -40.234  1    79.104  ? 277  ARG A CZ    1 ? 
ATOM   2237  N  NH1   . ARG A 1 277 ? 5.861   11.228  -40.85   1    82.796  ? 277  ARG A NH1   1 ? 
ATOM   2238  N  NH2   . ARG A 1 277 ? 8.054   10.844  -40.302  1    86.895  ? 277  ARG A NH2   1 ? 
ATOM   2239  N  N     . ILE A 1 278 ? 0.748   5.939   -41.243  1    40.783  ? 278  ILE A N     1 ? 
ATOM   2240  C  CA    . ILE A 1 278 ? -0.593  5.678   -41.765  1    41.839  ? 278  ILE A CA    1 ? 
ATOM   2241  C  C     . ILE A 1 278 ? -1.54   5.331   -40.609  1    38.376  ? 278  ILE A C     1 ? 
ATOM   2242  O  O     . ILE A 1 278 ? -2.723  5.699   -40.607  1    36.523  ? 278  ILE A O     1 ? 
ATOM   2243  C  CB    . ILE A 1 278 ? -0.582  4.614   -42.893  1    44.065  ? 278  ILE A CB    1 ? 
ATOM   2244  C  CG1   . ILE A 1 278 ? 0.241   5.068   -44.136  1    44.964  ? 278  ILE A CG1   1 ? 
ATOM   2245  C  CG2   . ILE A 1 278 ? -1.991  4.201   -43.319  1    34.766  ? 278  ILE A CG2   1 ? 
ATOM   2246  C  CD1   . ILE A 1 278 ? -0.473  6.095   -45.005  1    48.456  ? 278  ILE A CD1   1 ? 
ATOM   2247  N  N     . ILE A 1 279 ? -1.003  4.614   -39.618  1    38.688  ? 279  ILE A N     1 ? 
ATOM   2248  C  CA    . ILE A 1 279 ? -1.789  4.168   -38.477  1    35.258  ? 279  ILE A CA    1 ? 
ATOM   2249  C  C     . ILE A 1 279 ? -2.185  5.402   -37.663  1    29.634  ? 279  ILE A C     1 ? 
ATOM   2250  O  O     . ILE A 1 279 ? -3.33   5.545   -37.254  1    35.729  ? 279  ILE A O     1 ? 
ATOM   2251  C  CB    . ILE A 1 279 ? -1.025  3.091   -37.686  1    40.748  ? 279  ILE A CB    1 ? 
ATOM   2252  C  CG1   . ILE A 1 279 ? -0.975  1.756   -38.487  1    40.404  ? 279  ILE A CG1   1 ? 
ATOM   2253  C  CG2   . ILE A 1 279 ? -1.627  2.891   -36.284  1    36.946  ? 279  ILE A CG2   1 ? 
ATOM   2254  C  CD1   . ILE A 1 279 ? 0.14    0.792   -38.079  1    34.499  ? 279  ILE A CD1   1 ? 
ATOM   2255  N  N     . ASP A 1 280 ? -1.256  6.342   -37.55   1    29.738  ? 280  ASP A N     1 ? 
ATOM   2256  C  CA    . ASP A 1 280 ? -1.523  7.611   -36.902  1    37.986  ? 280  ASP A CA    1 ? 
ATOM   2257  C  C     . ASP A 1 280 ? -2.737  8.288   -37.541  1    41.515  ? 280  ASP A C     1 ? 
ATOM   2258  O  O     . ASP A 1 280 ? -3.668  8.7     -36.84   1    37.836  ? 280  ASP A O     1 ? 
ATOM   2259  C  CB    . ASP A 1 280 ? -0.227  8.354   -36.641  1    31.729  ? 280  ASP A CB    1 ? 
ATOM   2260  C  CG    . ASP A 1 280 ? 0.636   7.687   -35.578  1    35.563  ? 280  ASP A CG    1 ? 
ATOM   2261  O  OD1   . ASP A 1 280 ? 0.129   6.75    -34.915  1    37.873  ? 280  ASP A OD1   1 ? 
ATOM   2262  O  OD2   . ASP A 1 280 ? 1.809   8.083   -35.421  1    32.706  ? 280  ASP A OD2   1 ? 
ATOM   2263  N  N     . ASP A 1 281 ? -2.757  8.331   -38.876  1    40.361  ? 281  ASP A N     1 ? 
ATOM   2264  C  CA    . ASP A 1 281 ? -3.811  9.041   -39.571  1    36.748  ? 281  ASP A CA    1 ? 
ATOM   2265  C  C     . ASP A 1 281 ? -5.106  8.262   -39.456  1    33.629  ? 281  ASP A C     1 ? 
ATOM   2266  O  O     . ASP A 1 281 ? -6.181  8.867   -39.376  1    39.286  ? 281  ASP A O     1 ? 
ATOM   2267  C  CB    . ASP A 1 281 ? -3.386  9.508   -40.959  1    42.666  ? 281  ASP A CB    1 ? 
ATOM   2268  C  CG    . ASP A 1 281 ? -2.424  10.686  -40.954  1    44.828  ? 281  ASP A CG    1 ? 
ATOM   2269  O  OD1   . ASP A 1 281 ? -2.144  11.201  -39.849  1    49.176  ? 281  ASP A OD1   1 ? 
ATOM   2270  O  OD2   . ASP A 1 281 ? -1.96   11.082  -42.04   1    47.435  ? 281  ASP A OD2   1 ? 
ATOM   2271  N  N     . TRP A 1 282 ? -4.985  6.93    -39.43   1    32.002  ? 282  TRP A N     1 ? 
ATOM   2272  C  CA    . TRP A 1 282 ? -6.132  6.045   -39.289  1    28.366  ? 282  TRP A CA    1 ? 
ATOM   2273  C  C     . TRP A 1 282 ? -6.799  6.294   -37.936  1    31.333  ? 282  TRP A C     1 ? 
ATOM   2274  O  O     . TRP A 1 282 ? -8.024  6.32    -37.827  1    33.286  ? 282  TRP A O     1 ? 
ATOM   2275  C  CB    . TRP A 1 282 ? -5.664  4.585   -39.398  1    30.116  ? 282  TRP A CB    1 ? 
ATOM   2276  C  CG    . TRP A 1 282 ? -6.796  3.606   -39.558  1    31.815  ? 282  TRP A CG    1 ? 
ATOM   2277  C  CD1   . TRP A 1 282 ? -7.374  3.229   -40.734  1    37.366  ? 282  TRP A CD1   1 ? 
ATOM   2278  C  CD2   . TRP A 1 282 ? -7.546  2.939   -38.516  1    36.616  ? 282  TRP A CD2   1 ? 
ATOM   2279  N  NE1   . TRP A 1 282 ? -8.402  2.354   -40.508  1    38.913  ? 282  TRP A NE1   1 ? 
ATOM   2280  C  CE2   . TRP A 1 282 ? -8.54   2.164   -39.157  1    39.758  ? 282  TRP A CE2   1 ? 
ATOM   2281  C  CE3   . TRP A 1 282 ? -7.475  2.915   -37.115  1    36.659  ? 282  TRP A CE3   1 ? 
ATOM   2282  C  CZ2   . TRP A 1 282 ? -9.444  1.379   -38.447  1    37.171  ? 282  TRP A CZ2   1 ? 
ATOM   2283  C  CZ3   . TRP A 1 282 ? -8.375  2.148   -36.414  1    32.553  ? 282  TRP A CZ3   1 ? 
ATOM   2284  C  CH2   . TRP A 1 282 ? -9.351  1.398   -37.074  1    37.686  ? 282  TRP A CH2   1 ? 
ATOM   2285  N  N     . ILE A 1 283 ? -5.972  6.447   -36.892  1    33.329  ? 283  ILE A N     1 ? 
ATOM   2286  C  CA    . ILE A 1 283 ? -6.468  6.668   -35.54   1    31.185  ? 283  ILE A CA    1 ? 
ATOM   2287  C  C     . ILE A 1 283 ? -7.129  8.049   -35.467  1    30.901  ? 283  ILE A C     1 ? 
ATOM   2288  O  O     . ILE A 1 283 ? -8.139  8.226   -34.78   1    29.258  ? 283  ILE A O     1 ? 
ATOM   2289  C  CB    . ILE A 1 283 ? -5.304  6.536   -34.539  1    29.617  ? 283  ILE A CB    1 ? 
ATOM   2290  C  CG1   . ILE A 1 283 ? -4.782  5.094   -34.415  1    27.363  ? 283  ILE A CG1   1 ? 
ATOM   2291  C  CG2   . ILE A 1 283 ? -5.691  7.117   -33.171  1    32.303  ? 283  ILE A CG2   1 ? 
ATOM   2292  C  CD1   . ILE A 1 283 ? -3.385  5.026   -33.778  1    27.4    ? 283  ILE A CD1   1 ? 
ATOM   2293  N  N     . LEU A 1 284 ? -6.532  9.037   -36.144  1    26.806  ? 284  LEU A N     1 ? 
ATOM   2294  C  CA    . LEU A 1 284 ? -7.121  10.382  -36.176  1    31.733  ? 284  LEU A CA    1 ? 
ATOM   2295  C  C     . LEU A 1 284 ? -8.537  10.336  -36.75   1    31.715  ? 284  LEU A C     1 ? 
ATOM   2296  O  O     . LEU A 1 284 ? -9.469  10.892  -36.18   1    37.141  ? 284  LEU A O     1 ? 
ATOM   2297  C  CB    . LEU A 1 284 ? -6.249  11.376  -36.946  1    29.544  ? 284  LEU A CB    1 ? 
ATOM   2298  C  CG    . LEU A 1 284 ? -6.911  12.711  -37.312  1    32.227  ? 284  LEU A CG    1 ? 
ATOM   2299  C  CD1   . LEU A 1 284 ? -7.357  13.52   -36.087  1    27.357  ? 284  LEU A CD1   1 ? 
ATOM   2300  C  CD2   . LEU A 1 284 ? -5.972  13.545  -38.171  1    29.177  ? 284  LEU A CD2   1 ? 
ATOM   2301  N  N     . MET A 1 285 ? -8.71   9.61    -37.85   1    32.845  ? 285  MET A N     1 ? 
ATOM   2302  C  CA    . MET A 1 285 ? -10.011 9.532   -38.491  1    33.769  ? 285  MET A CA    1 ? 
ATOM   2303  C  C     . MET A 1 285 ? -11.031 8.905   -37.549  1    37.729  ? 285  MET A C     1 ? 
ATOM   2304  O  O     . MET A 1 285 ? -12.189 9.32    -37.523  1    38.963  ? 285  MET A O     1 ? 
ATOM   2305  C  CB    . MET A 1 285 ? -9.935  8.813   -39.841  1    35.869  ? 285  MET A CB    1 ? 
ATOM   2306  C  CG    . MET A 1 285 ? -9.364  9.694   -40.948  1    43.598  ? 285  MET A CG    1 ? 
ATOM   2307  S  SD    . MET A 1 285 ? -9.133  8.887   -42.553  1    45.016  ? 285  MET A SD    1 ? 
ATOM   2308  C  CE    . MET A 1 285 ? -7.625  7.917   -42.372  1    42.899  ? 285  MET A CE    1 ? 
ATOM   2309  N  N     . GLY A 1 286 ? -10.57  7.94    -36.743  1    40.479  ? 286  GLY A N     1 ? 
ATOM   2310  C  CA    . GLY A 1 286 ? -11.424 7.263   -35.781  1    41.026  ? 286  GLY A CA    1 ? 
ATOM   2311  C  C     . GLY A 1 286 ? -12.097 8.228   -34.809  1    41.362  ? 286  GLY A C     1 ? 
ATOM   2312  O  O     . GLY A 1 286 ? -13.247 8.017   -34.43   1    38.971  ? 286  GLY A O     1 ? 
ATOM   2313  N  N     . PHE A 1 287 ? -11.384 9.293   -34.427  1    41.482  ? 287  PHE A N     1 ? 
ATOM   2314  C  CA    . PHE A 1 287 ? -11.922 10.283  -33.506  1    43.377  ? 287  PHE A CA    1 ? 
ATOM   2315  C  C     . PHE A 1 287 ? -13.167 10.995  -34.054  1    48.019  ? 287  PHE A C     1 ? 
ATOM   2316  O  O     . PHE A 1 287 ? -13.963 11.492  -33.25   1    46.716  ? 287  PHE A O     1 ? 
ATOM   2317  C  CB    . PHE A 1 287 ? -10.84  11.251  -33.006  1    43.221  ? 287  PHE A CB    1 ? 
ATOM   2318  C  CG    . PHE A 1 287 ? -9.684  10.615  -32.248  1    43.124  ? 287  PHE A CG    1 ? 
ATOM   2319  C  CD1   . PHE A 1 287 ? -9.877  9.497   -31.437  1    44.04   ? 287  PHE A CD1   1 ? 
ATOM   2320  C  CD2   . PHE A 1 287 ? -8.404  11.162  -32.321  1    48.327  ? 287  PHE A CD2   1 ? 
ATOM   2321  C  CE1   . PHE A 1 287 ? -8.814  8.926   -30.746  1    50.231  ? 287  PHE A CE1   1 ? 
ATOM   2322  C  CE2   . PHE A 1 287 ? -7.34   10.589  -31.623  1    44.626  ? 287  PHE A CE2   1 ? 
ATOM   2323  C  CZ    . PHE A 1 287 ? -7.546  9.467   -30.851  1    42.864  ? 287  PHE A CZ    1 ? 
ATOM   2324  N  N     . LEU A 1 288 ? -13.379 11.027  -35.387  1    48.314  ? 288  LEU A N     1 ? 
ATOM   2325  C  CA    . LEU A 1 288 ? -14.453 11.852  -35.959  1    43.528  ? 288  LEU A CA    1 ? 
ATOM   2326  C  C     . LEU A 1 288 ? -15.87  11.332  -35.675  1    46.755  ? 288  LEU A C     1 ? 
ATOM   2327  O  O     . LEU A 1 288 ? -16.841 12.093  -35.774  1    48.125  ? 288  LEU A O     1 ? 
ATOM   2328  C  CB    . LEU A 1 288 ? -14.261 12.148  -37.446  1    47.31   ? 288  LEU A CB    1 ? 
ATOM   2329  C  CG    . LEU A 1 288 ? -12.872 12.621  -37.897  1    46.986  ? 288  LEU A CG    1 ? 
ATOM   2330  C  CD1   . LEU A 1 288 ? -13.024 13.044  -39.35   1    50.076  ? 288  LEU A CD1   1 ? 
ATOM   2331  C  CD2   . LEU A 1 288 ? -12.259 13.752  -37.075  1    49.231  ? 288  LEU A CD2   1 ? 
ATOM   2332  N  N     . VAL A 1 289 ? -16.01  10.049  -35.301  1    46.356  ? 289  VAL A N     1 ? 
ATOM   2333  C  CA    . VAL A 1 289 ? -17.317 9.482   -34.993  1    47.371  ? 289  VAL A CA    1 ? 
ATOM   2334  C  C     . VAL A 1 289 ? -17.775 9.752   -33.543  1    52.786  ? 289  VAL A C     1 ? 
ATOM   2335  O  O     . VAL A 1 289 ? -18.872 9.329   -33.161  1    49.326  ? 289  VAL A O     1 ? 
ATOM   2336  C  CB    . VAL A 1 289 ? -17.279 7.979   -35.326  1    52.246  ? 289  VAL A CB    1 ? 
ATOM   2337  C  CG1   . VAL A 1 289 ? -16.515 7.722   -36.627  1    54.657  ? 289  VAL A CG1   1 ? 
ATOM   2338  C  CG2   . VAL A 1 289 ? -16.688 7.165   -34.185  1    46.046  ? 289  VAL A CG2   1 ? 
ATOM   2339  N  N     . GLY A 1 290 ? -16.961 10.461  -32.734  1    54.041  ? 290  GLY A N     1 ? 
ATOM   2340  C  CA    . GLY A 1 290 ? -17.318 10.869  -31.377  1    46.534  ? 290  GLY A CA    1 ? 
ATOM   2341  C  C     . GLY A 1 290 ? -16.793 9.88    -30.329  1    46.267  ? 290  GLY A C     1 ? 
ATOM   2342  O  O     . GLY A 1 290 ? -16.571 8.713   -30.633  1    46.285  ? 290  GLY A O     1 ? 
ATOM   2343  N  N     . ASN A 1 291 ? -16.568 10.371  -29.097  1    37.926  ? 291  ASN A N     1 ? 
ATOM   2344  C  CA    . ASN A 1 291 ? -16.061 9.591   -27.98   1    36.147  ? 291  ASN A CA    1 ? 
ATOM   2345  C  C     . ASN A 1 291 ? -16.541 10.268  -26.699  1    44.656  ? 291  ASN A C     1 ? 
ATOM   2346  O  O     . ASN A 1 291 ? -17.484 11.066  -26.723  1    37.607  ? 291  ASN A O     1 ? 
ATOM   2347  C  CB    . ASN A 1 291 ? -14.541 9.489   -28.005  1    35.046  ? 291  ASN A CB    1 ? 
ATOM   2348  C  CG    . ASN A 1 291 ? -13.937 10.829  -28.363  1    47.284  ? 291  ASN A CG    1 ? 
ATOM   2349  O  OD1   . ASN A 1 291 ? -14.049 11.809  -27.606  1    42.174  ? 291  ASN A OD1   1 ? 
ATOM   2350  N  ND2   . ASN A 1 291 ? -13.386 10.918  -29.565  1    47.603  ? 291  ASN A ND2   1 ? 
ATOM   2351  N  N     . ASP A 1 292 ? -15.845 9.986   -25.591  1    41.428  ? 292  ASP A N     1 ? 
ATOM   2352  C  CA    . ASP A 1 292 ? -16.24  10.544  -24.312  1    44.595  ? 292  ASP A CA    1 ? 
ATOM   2353  C  C     . ASP A 1 292 ? -15.943 12.05   -24.292  1    34.962  ? 292  ASP A C     1 ? 
ATOM   2354  O  O     . ASP A 1 292 ? -16.394 12.738  -23.378  1    36.014  ? 292  ASP A O     1 ? 
ATOM   2355  C  CB    . ASP A 1 292 ? -15.579 9.795   -23.156  1    54.05   ? 292  ASP A CB    1 ? 
ATOM   2356  C  CG    . ASP A 1 292 ? -15.938 8.32    -22.945  1    67.741  ? 292  ASP A CG    1 ? 
ATOM   2357  O  OD1   . ASP A 1 292 ? -17.043 7.908   -23.408  1    63.778  ? 292  ASP A OD1   1 ? 
ATOM   2358  O  OD2   . ASP A 1 292 ? -15.092 7.59    -22.315  1    60.912  ? 292  ASP A OD2   1 ? 
ATOM   2359  N  N     . PHE A 1 293 ? -15.153 12.54   -25.261  1    31.267  ? 293  PHE A N     1 ? 
ATOM   2360  C  CA    . PHE A 1 293 ? -14.546 13.866  -25.154  1    27.915  ? 293  PHE A CA    1 ? 
ATOM   2361  C  C     . PHE A 1 293 ? -15.127 14.864  -26.157  1    25.911  ? 293  PHE A C     1 ? 
ATOM   2362  O  O     . PHE A 1 293 ? -15.07  16.079  -25.913  1    26.912  ? 293  PHE A O     1 ? 
ATOM   2363  C  CB    . PHE A 1 293 ? -13.012 13.878  -25.228  1    24.181  ? 293  PHE A CB    1 ? 
ATOM   2364  C  CG    . PHE A 1 293 ? -12.452 12.901  -24.209  1    31.372  ? 293  PHE A CG    1 ? 
ATOM   2365  C  CD1   . PHE A 1 293 ? -12.508 13.192  -22.847  1    28.996  ? 293  PHE A CD1   1 ? 
ATOM   2366  C  CD2   . PHE A 1 293 ? -11.902 11.686  -24.615  1    30.936  ? 293  PHE A CD2   1 ? 
ATOM   2367  C  CE1   . PHE A 1 293 ? -12.014 12.293  -21.907  1    31.926  ? 293  PHE A CE1   1 ? 
ATOM   2368  C  CE2   . PHE A 1 293 ? -11.42  10.784  -23.676  1    34.269  ? 293  PHE A CE2   1 ? 
ATOM   2369  C  CZ    . PHE A 1 293 ? -11.509 11.075  -22.324  1    35.548  ? 293  PHE A CZ    1 ? 
ATOM   2370  N  N     . ILE A 1 294 ? -15.593 14.355  -27.301  1    26.591  ? 294  ILE A N     1 ? 
ATOM   2371  C  CA    . ILE A 1 294 ? -16.047 15.232  -28.383  1    32.176  ? 294  ILE A CA    1 ? 
ATOM   2372  C  C     . ILE A 1 294 ? -17.313 14.614  -28.983  1    26.606  ? 294  ILE A C     1 ? 
ATOM   2373  O  O     . ILE A 1 294 ? -17.315 13.437  -29.305  1    26.636  ? 294  ILE A O     1 ? 
ATOM   2374  C  CB    . ILE A 1 294 ? -14.97  15.393  -29.48   1    34.289  ? 294  ILE A CB    1 ? 
ATOM   2375  C  CG1   . ILE A 1 294 ? -13.587 15.629  -28.913  1    45.714  ? 294  ILE A CG1   1 ? 
ATOM   2376  C  CG2   . ILE A 1 294 ? -15.319 16.488  -30.482  1    36.149  ? 294  ILE A CG2   1 ? 
ATOM   2377  C  CD1   . ILE A 1 294 ? -12.523 15.769  -29.995  1    49.427  ? 294  ILE A CD1   1 ? 
ATOM   2378  N  N     . PRO A 1 295 ? -18.398 15.391  -29.187  1    30.526  ? 295  PRO A N     1 ? 
ATOM   2379  C  CA    . PRO A 1 295 ? -19.622 14.854  -29.783  1    28.586  ? 295  PRO A CA    1 ? 
ATOM   2380  C  C     . PRO A 1 295 ? -19.341 14.547  -31.26   1    29.653  ? 295  PRO A C     1 ? 
ATOM   2381  O  O     . PRO A 1 295 ? -18.49  15.173  -31.869  1    30.29   ? 295  PRO A O     1 ? 
ATOM   2382  C  CB    . PRO A 1 295 ? -20.656 15.982  -29.642  1    28.815  ? 295  PRO A CB    1 ? 
ATOM   2383  C  CG    . PRO A 1 295 ? -19.963 17.05   -28.855  1    32.436  ? 295  PRO A CG    1 ? 
ATOM   2384  C  CD    . PRO A 1 295 ? -18.453 16.842  -28.915  1    26.123  ? 295  PRO A CD    1 ? 
ATOM   2385  N  N     . HIS A 1 296 ? -20.036 13.553  -31.817  1    28.35   ? 296  HIS A N     1 ? 
ATOM   2386  C  CA    . HIS A 1 296 ? -19.867 13.154  -33.207  1    30.053  ? 296  HIS A CA    1 ? 
ATOM   2387  C  C     . HIS A 1 296 ? -20.31  14.297  -34.122  1    29.487  ? 296  HIS A C     1 ? 
ATOM   2388  O  O     . HIS A 1 296 ? -21.199 15.08   -33.77   1    29.497  ? 296  HIS A O     1 ? 
ATOM   2389  C  CB    . HIS A 1 296 ? -20.692 11.884  -33.458  1    30.578  ? 296  HIS A CB    1 ? 
ATOM   2390  C  CG    . HIS A 1 296 ? -22.155 12.144  -33.323  1    38.153  ? 296  HIS A CG    1 ? 
ATOM   2391  N  ND1   . HIS A 1 296 ? -22.926 12.619  -34.371  1    37.393  ? 296  HIS A ND1   1 ? 
ATOM   2392  C  CD2   . HIS A 1 296 ? -22.982 12.062  -32.249  1    37.943  ? 296  HIS A CD2   1 ? 
ATOM   2393  C  CE1   . HIS A 1 296 ? -24.183 12.78   -33.941  1    41.447  ? 296  HIS A CE1   1 ? 
ATOM   2394  N  NE2   . HIS A 1 296 ? -24.239 12.45   -32.647  1    38.187  ? 296  HIS A NE2   1 ? 
ATOM   2395  N  N     . LEU A 1 297 ? -19.674 14.389  -35.293  1    29.628  ? 297  LEU A N     1 ? 
ATOM   2396  C  CA    . LEU A 1 297 ? -20.09  15.272  -36.384  1    30.68   ? 297  LEU A CA    1 ? 
ATOM   2397  C  C     . LEU A 1 297 ? -21.493 14.879  -36.85   1    29.089  ? 297  LEU A C     1 ? 
ATOM   2398  O  O     . LEU A 1 297 ? -21.853 13.701  -36.793  1    29.037  ? 297  LEU A O     1 ? 
ATOM   2399  C  CB    . LEU A 1 297 ? -19.072 15.203  -37.524  1    32.369  ? 297  LEU A CB    1 ? 
ATOM   2400  C  CG    . LEU A 1 297 ? -17.676 15.742  -37.198  1    30.742  ? 297  LEU A CG    1 ? 
ATOM   2401  C  CD1   . LEU A 1 297 ? -16.686 15.308  -38.266  1    35.828  ? 297  LEU A CD1   1 ? 
ATOM   2402  C  CD2   . LEU A 1 297 ? -17.646 17.237  -37.099  1    34.148  ? 297  LEU A CD2   1 ? 
ATOM   2403  N  N     . PRO A 1 298 ? -22.373 15.85   -37.194  1    28.217  ? 298  PRO A N     1 ? 
ATOM   2404  C  CA    . PRO A 1 298 ? -23.736 15.534  -37.621  1    31.524  ? 298  PRO A CA    1 ? 
ATOM   2405  C  C     . PRO A 1 298 ? -23.724 14.51   -38.759  1    38.591  ? 298  PRO A C     1 ? 
ATOM   2406  O  O     . PRO A 1 298 ? -22.894 14.595  -39.676  1    37.701  ? 298  PRO A O     1 ? 
ATOM   2407  C  CB    . PRO A 1 298 ? -24.209 16.922  -38.086  1    33.222  ? 298  PRO A CB    1 ? 
ATOM   2408  C  CG    . PRO A 1 298 ? -23.494 17.885  -37.172  1    30.512  ? 298  PRO A CG    1 ? 
ATOM   2409  C  CD    . PRO A 1 298 ? -22.107 17.293  -37.156  1    28.006  ? 298  PRO A CD    1 ? 
ATOM   2410  N  N     . HIS A 1 299 ? -24.616 13.512  -38.629  1    43.206  ? 299  HIS A N     1 ? 
ATOM   2411  C  CA    . HIS A 1 299 ? -24.88  12.446  -39.594  1    51.887  ? 299  HIS A CA    1 ? 
ATOM   2412  C  C     . HIS A 1 299 ? -23.727 11.447  -39.724  1    55.222  ? 299  HIS A C     1 ? 
ATOM   2413  O  O     . HIS A 1 299 ? -23.78  10.532  -40.542  1    57.705  ? 299  HIS A O     1 ? 
ATOM   2414  C  CB    . HIS A 1 299 ? -25.477 12.997  -40.893  1    50.767  ? 299  HIS A CB    1 ? 
ATOM   2415  C  CG    . HIS A 1 299 ? -26.477 14.057  -40.572  1    49.814  ? 299  HIS A CG    1 ? 
ATOM   2416  N  ND1   . HIS A 1 299 ? -26.259 15.386  -40.862  1    51.798  ? 299  HIS A ND1   1 ? 
ATOM   2417  C  CD2   . HIS A 1 299 ? -27.662 14.002  -39.94   1    51.815  ? 299  HIS A CD2   1 ? 
ATOM   2418  C  CE1   . HIS A 1 299 ? -27.302 16.102  -40.442  1    51.86   ? 299  HIS A CE1   1 ? 
ATOM   2419  N  NE2   . HIS A 1 299 ? -28.164 15.283  -39.875  1    52.23   ? 299  HIS A NE2   1 ? 
ATOM   2420  N  N     . LEU A 1 300 ? -22.72  11.563  -38.861  1    54.139  ? 300  LEU A N     1 ? 
ATOM   2421  C  CA    . LEU A 1 300 ? -21.558 10.7    -38.957  1    57.246  ? 300  LEU A CA    1 ? 
ATOM   2422  C  C     . LEU A 1 300 ? -21.469 9.785   -37.737  1    56.916  ? 300  LEU A C     1 ? 
ATOM   2423  O  O     . LEU A 1 300 ? -20.822 10.149  -36.763  1    56.718  ? 300  LEU A O     1 ? 
ATOM   2424  C  CB    . LEU A 1 300 ? -20.378 11.653  -39.107  1    52.428  ? 300  LEU A CB    1 ? 
ATOM   2425  C  CG    . LEU A 1 300 ? -18.97  11.058  -39.029  1    64.681  ? 300  LEU A CG    1 ? 
ATOM   2426  C  CD1   . LEU A 1 300 ? -18.891 9.626   -39.544  1    70.135  ? 300  LEU A CD1   1 ? 
ATOM   2427  C  CD2   . LEU A 1 300 ? -18.123 11.992  -39.879  1    59.84   ? 300  LEU A CD2   1 ? 
ATOM   2428  N  N     . HIS A 1 301 ? -22.126 8.61    -37.825  1    62.742  ? 301  HIS A N     1 ? 
ATOM   2429  C  CA    . HIS A 1 301 ? -22.147 7.536   -36.834  1    69.741  ? 301  HIS A CA    1 ? 
ATOM   2430  C  C     . HIS A 1 301 ? -21.418 6.299   -37.37   1    78.276  ? 301  HIS A C     1 ? 
ATOM   2431  O  O     . HIS A 1 301 ? -21.114 6.216   -38.558  1    71.64   ? 301  HIS A O     1 ? 
ATOM   2432  C  CB    . HIS A 1 301 ? -23.589 7.108   -36.535  1    79.534  ? 301  HIS A CB    1 ? 
ATOM   2433  C  CG    . HIS A 1 301 ? -24.429 8.183   -35.926  1    103.662 ? 301  HIS A CG    1 ? 
ATOM   2434  N  ND1   . HIS A 1 301 ? -25.061 9.147   -36.682  1    111.566 ? 301  HIS A ND1   1 ? 
ATOM   2435  C  CD2   . HIS A 1 301 ? -24.728 8.462   -34.645  1    112.373 ? 301  HIS A CD2   1 ? 
ATOM   2436  C  CE1   . HIS A 1 301 ? -25.724 9.97    -35.878  1    113.023 ? 301  HIS A CE1   1 ? 
ATOM   2437  N  NE2   . HIS A 1 301 ? -25.534 9.573   -34.636  1    112.404 ? 301  HIS A NE2   1 ? 
ATOM   2438  N  N     . ILE A 1 302 ? -21.15  5.314   -36.502  1    75.726  ? 302  ILE A N     1 ? 
ATOM   2439  C  CA    . ILE A 1 302 ? -20.489 4.103   -36.974  1    75.39   ? 302  ILE A CA    1 ? 
ATOM   2440  C  C     . ILE A 1 302 ? -21.521 3.241   -37.699  1    72.692  ? 302  ILE A C     1 ? 
ATOM   2441  O  O     . ILE A 1 302 ? -22.577 2.918   -37.149  1    70.475  ? 302  ILE A O     1 ? 
ATOM   2442  C  CB    . ILE A 1 302 ? -19.757 3.317   -35.864  1    67.875  ? 302  ILE A CB    1 ? 
ATOM   2443  C  CG1   . ILE A 1 302 ? -18.848 4.2     -35.005  1    60.578  ? 302  ILE A CG1   1 ? 
ATOM   2444  C  CG2   . ILE A 1 302 ? -18.978 2.149   -36.471  1    66.082  ? 302  ILE A CG2   1 ? 
ATOM   2445  C  CD1   . ILE A 1 302 ? -18.641 3.681   -33.593  1    59.828  ? 302  ILE A CD1   1 ? 
ATOM   2446  N  N     . ASN A 1 303 ? -21.172 2.885   -38.942  1    73.216  ? 303  ASN A N     1 ? 
ATOM   2447  C  CA    . ASN A 1 303 ? -21.944 2.04    -39.843  1    66.961  ? 303  ASN A CA    1 ? 
ATOM   2448  C  C     . ASN A 1 303 ? -21.085 1.792   -41.085  1    69.178  ? 303  ASN A C     1 ? 
ATOM   2449  O  O     . ASN A 1 303 ? -19.879 2.02    -41.052  1    70.213  ? 303  ASN A O     1 ? 
ATOM   2450  C  CB    . ASN A 1 303 ? -23.306 2.652   -40.152  1    55.799  ? 303  ASN A CB    1 ? 
ATOM   2451  C  CG    . ASN A 1 303 ? -23.168 4.076   -40.625  1    58.776  ? 303  ASN A CG    1 ? 
ATOM   2452  O  OD1   . ASN A 1 303 ? -22.418 4.346   -41.576  1    60.476  ? 303  ASN A OD1   1 ? 
ATOM   2453  N  ND2   . ASN A 1 303 ? -23.862 4.996   -39.965  1    56.476  ? 303  ASN A ND2   1 ? 
ATOM   2454  N  N     . HIS A 1 304 ? -21.707 1.377   -42.194  1    72.739  ? 304  HIS A N     1 ? 
ATOM   2455  C  CA    . HIS A 1 304 ? -20.951 0.902   -43.344  1    79.765  ? 304  HIS A CA    1 ? 
ATOM   2456  C  C     . HIS A 1 304 ? -20.404 2.048   -44.212  1    86.753  ? 304  HIS A C     1 ? 
ATOM   2457  O  O     . HIS A 1 304 ? -19.293 1.939   -44.722  1    80.695  ? 304  HIS A O     1 ? 
ATOM   2458  C  CB    . HIS A 1 304 ? -21.783 -0.107  -44.141  1    84.118  ? 304  HIS A CB    1 ? 
ATOM   2459  C  CG    . HIS A 1 304 ? -22.504 0.527   -45.281  1    100.235 ? 304  HIS A CG    1 ? 
ATOM   2460  N  ND1   . HIS A 1 304 ? -23.677 1.232   -45.136  1    106.938 ? 304  HIS A ND1   1 ? 
ATOM   2461  C  CD2   . HIS A 1 304 ? -22.181 0.599   -46.582  1    104.237 ? 304  HIS A CD2   1 ? 
ATOM   2462  C  CE1   . HIS A 1 304 ? -24.055 1.69    -46.323  1    121.15  ? 304  HIS A CE1   1 ? 
ATOM   2463  N  NE2   . HIS A 1 304 ? -23.162 1.313   -47.216  1    119.219 ? 304  HIS A NE2   1 ? 
ATOM   2464  N  N     . ASP A 1 305 ? -21.179 3.13    -44.404  1    90.76   ? 305  ASP A N     1 ? 
ATOM   2465  C  CA    . ASP A 1 305 ? -20.864 4.165   -45.387  1    85.759  ? 305  ASP A CA    1 ? 
ATOM   2466  C  C     . ASP A 1 305 ? -19.941 5.239   -44.809  1    92.066  ? 305  ASP A C     1 ? 
ATOM   2467  O  O     . ASP A 1 305 ? -19.011 5.684   -45.483  1    90.57   ? 305  ASP A O     1 ? 
ATOM   2468  C  CB    . ASP A 1 305 ? -22.119 4.805   -45.962  1    80.738  ? 305  ASP A CB    1 ? 
ATOM   2469  C  CG    . ASP A 1 305 ? -23.098 5.367   -44.939  1    90.492  ? 305  ASP A CG    1 ? 
ATOM   2470  O  OD1   . ASP A 1 305 ? -22.766 6.393   -44.296  1    94.081  ? 305  ASP A OD1   1 ? 
ATOM   2471  O  OD2   . ASP A 1 305 ? -24.178 4.76    -44.773  1    92.72   ? 305  ASP A OD2   1 ? 
ATOM   2472  N  N     . ALA A 1 306 ? -20.225 5.672   -43.573  1    86.29   ? 306  ALA A N     1 ? 
ATOM   2473  C  CA    . ALA A 1 306 ? -19.55  6.802   -42.959  1    72.127  ? 306  ALA A CA    1 ? 
ATOM   2474  C  C     . ALA A 1 306 ? -18.037 6.601   -42.997  1    70.059  ? 306  ALA A C     1 ? 
ATOM   2475  O  O     . ALA A 1 306 ? -17.298 7.433   -43.516  1    76.123  ? 306  ALA A O     1 ? 
ATOM   2476  C  CB    . ALA A 1 306 ? -20.038 6.947   -41.543  1    86.116  ? 306  ALA A CB    1 ? 
ATOM   2477  N  N     . LEU A 1 307 ? -17.59  5.462   -42.479  1    51.694  ? 307  LEU A N     1 ? 
ATOM   2478  C  CA    . LEU A 1 307 ? -16.18  5.214   -42.244  1    68.258  ? 307  LEU A CA    1 ? 
ATOM   2479  C  C     . LEU A 1 307 ? -15.413 5.123   -43.569  1    85.545  ? 307  LEU A C     1 ? 
ATOM   2480  O  O     . LEU A 1 307 ? -14.394 5.801   -43.729  1    84.852  ? 307  LEU A O     1 ? 
ATOM   2481  C  CB    . LEU A 1 307 ? -15.993 3.972   -41.363  1    82.806  ? 307  LEU A CB    1 ? 
ATOM   2482  C  CG    . LEU A 1 307 ? -16.352 4.056   -39.868  1    78.749  ? 307  LEU A CG    1 ? 
ATOM   2483  C  CD1   . LEU A 1 307 ? -15.649 5.197   -39.145  1    79.919  ? 307  LEU A CD1   1 ? 
ATOM   2484  C  CD2   . LEU A 1 307 ? -17.846 4.06    -39.569  1    74.931  ? 307  LEU A CD2   1 ? 
ATOM   2485  N  N     . PRO A 1 308 ? -15.852 4.324   -44.581  1    78.465  ? 308  PRO A N     1 ? 
ATOM   2486  C  CA    . PRO A 1 308 ? -15.07  4.184   -45.81   1    68.747  ? 308  PRO A CA    1 ? 
ATOM   2487  C  C     . PRO A 1 308 ? -15.01  5.572   -46.426  1    54.046  ? 308  PRO A C     1 ? 
ATOM   2488  O  O     . PRO A 1 308 ? -14.007 5.923   -47.053  1    53.013  ? 308  PRO A O     1 ? 
ATOM   2489  C  CB    . PRO A 1 308 ? -15.849 3.192   -46.68   1    70.323  ? 308  PRO A CB    1 ? 
ATOM   2490  C  CG    . PRO A 1 308 ? -17.258 3.288   -46.134  1    77.854  ? 308  PRO A CG    1 ? 
ATOM   2491  C  CD    . PRO A 1 308 ? -17.123 3.584   -44.642  1    72.971  ? 308  PRO A CD    1 ? 
ATOM   2492  N  N     . LEU A 1 309 ? -16.071 6.356   -46.187  1    49.554  ? 309  LEU A N     1 ? 
ATOM   2493  C  CA    . LEU A 1 309 ? -16.116 7.727   -46.674  1    51.224  ? 309  LEU A CA    1 ? 
ATOM   2494  C  C     . LEU A 1 309 ? -14.938 8.501   -46.088  1    47.897  ? 309  LEU A C     1 ? 
ATOM   2495  O  O     . LEU A 1 309 ? -14.159 9.106   -46.825  1    53.649  ? 309  LEU A O     1 ? 
ATOM   2496  C  CB    . LEU A 1 309 ? -17.46  8.415   -46.427  1    52.309  ? 309  LEU A CB    1 ? 
ATOM   2497  C  CG    . LEU A 1 309 ? -17.52  9.916   -46.747  1    67.455  ? 309  LEU A CG    1 ? 
ATOM   2498  C  CD1   . LEU A 1 309 ? -17.203 10.296  -48.208  1    64.695  ? 309  LEU A CD1   1 ? 
ATOM   2499  C  CD2   . LEU A 1 309 ? -18.858 10.507  -46.308  1    77.724  ? 309  LEU A CD2   1 ? 
ATOM   2500  N  N     . LEU A 1 310 ? -14.767 8.414   -44.764  1    45.776  ? 310  LEU A N     1 ? 
ATOM   2501  C  CA    . LEU A 1 310 ? -13.587 8.999   -44.147  1    47.287  ? 310  LEU A CA    1 ? 
ATOM   2502  C  C     . LEU A 1 310 ? -12.326 8.425   -44.796  1    43.464  ? 310  LEU A C     1 ? 
ATOM   2503  O  O     . LEU A 1 310 ? -11.419 9.169   -45.13   1    44.427  ? 310  LEU A O     1 ? 
ATOM   2504  C  CB    . LEU A 1 310 ? -13.578 8.827   -42.627  1    50.595  ? 310  LEU A CB    1 ? 
ATOM   2505  C  CG    . LEU A 1 310 ? -14.893 9.126   -41.894  1    55.838  ? 310  LEU A CG    1 ? 
ATOM   2506  C  CD1   . LEU A 1 310 ? -14.774 8.958   -40.384  1    58.876  ? 310  LEU A CD1   1 ? 
ATOM   2507  C  CD2   . LEU A 1 310 ? -15.392 10.511  -42.224  1    58.764  ? 310  LEU A CD2   1 ? 
ATOM   2508  N  N     . TYR A 1 311 ? -12.264 7.096   -44.97   1    47.793  ? 311  TYR A N     1 ? 
ATOM   2509  C  CA    . TYR A 1 311 ? -11.026 6.464   -45.406  1    53.617  ? 311  TYR A CA    1 ? 
ATOM   2510  C  C     . TYR A 1 311 ? -10.82  6.688   -46.904  1    53.934  ? 311  TYR A C     1 ? 
ATOM   2511  O  O     . TYR A 1 311 ? -9.691  6.922   -47.332  1    50.497  ? 311  TYR A O     1 ? 
ATOM   2512  C  CB    . TYR A 1 311 ? -10.909 4.997   -44.966  1    65.701  ? 311  TYR A CB    1 ? 
ATOM   2513  C  CG    . TYR A 1 311 ? -11.195 4.764   -43.489  1    66.057  ? 311  TYR A CG    1 ? 
ATOM   2514  C  CD1   . TYR A 1 311 ? -10.252 5.058   -42.514  1    62.851  ? 311  TYR A CD1   1 ? 
ATOM   2515  C  CD2   . TYR A 1 311 ? -12.417 4.254   -43.073  1    74.568  ? 311  TYR A CD2   1 ? 
ATOM   2516  C  CE1   . TYR A 1 311 ? -10.515 4.858   -41.169  1    66.07   ? 311  TYR A CE1   1 ? 
ATOM   2517  C  CE2   . TYR A 1 311 ? -12.701 4.067   -41.729  1    79.401  ? 311  TYR A CE2   1 ? 
ATOM   2518  C  CZ    . TYR A 1 311 ? -11.745 4.364   -40.772  1    79.506  ? 311  TYR A CZ    1 ? 
ATOM   2519  O  OH    . TYR A 1 311 ? -12.026 4.165   -39.448  1    70.141  ? 311  TYR A OH    1 ? 
ATOM   2520  N  N     . GLY A 1 312 ? -11.916 6.602   -47.681  1    49.879  ? 312  GLY A N     1 ? 
ATOM   2521  C  CA    . GLY A 1 312 ? -11.891 6.875   -49.108  1    52.874  ? 312  GLY A CA    1 ? 
ATOM   2522  C  C     . GLY A 1 312 ? -11.414 8.294   -49.396  1    53.934  ? 312  GLY A C     1 ? 
ATOM   2523  O  O     . GLY A 1 312 ? -10.607 8.502   -50.306  1    55.011  ? 312  GLY A O     1 ? 
ATOM   2524  N  N     . THR A 1 313 ? -11.891 9.254   -48.582  1    50.476  ? 313  THR A N     1 ? 
ATOM   2525  C  CA    . THR A 1 313 ? -11.513 10.655  -48.726  1    44.36   ? 313  THR A CA    1 ? 
ATOM   2526  C  C     . THR A 1 313 ? -10.019 10.795  -48.447  1    47.184  ? 313  THR A C     1 ? 
ATOM   2527  O  O     . THR A 1 313 ? -9.332  11.592  -49.091  1    51.321  ? 313  THR A O     1 ? 
ATOM   2528  C  CB    . THR A 1 313 ? -12.37  11.476  -47.757  1    43.363  ? 313  THR A CB    1 ? 
ATOM   2529  O  OG1   . THR A 1 313 ? -13.703 11.255  -48.201  1    43.345  ? 313  THR A OG1   1 ? 
ATOM   2530  C  CG2   . THR A 1 313 ? -12.065 12.962  -47.751  1    37.669  ? 313  THR A CG2   1 ? 
ATOM   2531  N  N     . TYR A 1 314 ? -9.539  10.013  -47.465  1    44.986  ? 314  TYR A N     1 ? 
ATOM   2532  C  CA    . TYR A 1 314 ? -8.139  10.016  -47.065  1    49.622  ? 314  TYR A CA    1 ? 
ATOM   2533  C  C     . TYR A 1 314 ? -7.275  9.535   -48.236  1    45.99   ? 314  TYR A C     1 ? 
ATOM   2534  O  O     . TYR A 1 314 ? -6.257  10.158  -48.551  1    46.583  ? 314  TYR A O     1 ? 
ATOM   2535  C  CB    . TYR A 1 314 ? -7.898  9.28    -45.732  1    41.956  ? 314  TYR A CB    1 ? 
ATOM   2536  C  CG    . TYR A 1 314 ? -6.449  9.342   -45.26   1    40.501  ? 314  TYR A CG    1 ? 
ATOM   2537  C  CD1   . TYR A 1 314 ? -5.934  10.486  -44.643  1    40.908  ? 314  TYR A CD1   1 ? 
ATOM   2538  C  CD2   . TYR A 1 314 ? -5.575  8.278   -45.473  1    43.03   ? 314  TYR A CD2   1 ? 
ATOM   2539  C  CE1   . TYR A 1 314 ? -4.603  10.571  -44.258  1    36.55   ? 314  TYR A CE1   1 ? 
ATOM   2540  C  CE2   . TYR A 1 314 ? -4.244  8.337   -45.072  1    39.812  ? 314  TYR A CE2   1 ? 
ATOM   2541  C  CZ    . TYR A 1 314 ? -3.765  9.481   -44.459  1    41.008  ? 314  TYR A CZ    1 ? 
ATOM   2542  O  OH    . TYR A 1 314 ? -2.469  9.525   -44.065  1    39.52   ? 314  TYR A OH    1 ? 
ATOM   2543  N  N     . VAL A 1 315 ? -7.679  8.417   -48.862  1    53.586  ? 315  VAL A N     1 ? 
ATOM   2544  C  CA    . VAL A 1 315 ? -7.027  7.894   -50.061  1    55.116  ? 315  VAL A CA    1 ? 
ATOM   2545  C  C     . VAL A 1 315 ? -6.91   9.013   -51.094  1    52.684  ? 315  VAL A C     1 ? 
ATOM   2546  O  O     . VAL A 1 315 ? -5.806  9.351   -51.545  1    48.358  ? 315  VAL A O     1 ? 
ATOM   2547  C  CB    . VAL A 1 315 ? -7.83   6.706   -50.634  1    62.241  ? 315  VAL A CB    1 ? 
ATOM   2548  C  CG1   . VAL A 1 315 ? -7.39   6.316   -52.046  1    64.697  ? 315  VAL A CG1   1 ? 
ATOM   2549  C  CG2   . VAL A 1 315 ? -7.809  5.499   -49.706  1    64.525  ? 315  VAL A CG2   1 ? 
ATOM   2550  N  N     . THR A 1 316 ? -8.067  9.615   -51.403  1    52.988  ? 316  THR A N     1 ? 
ATOM   2551  C  CA    . THR A 1 316 ? -8.205  10.644  -52.425  1    53.506  ? 316  THR A CA    1 ? 
ATOM   2552  C  C     . THR A 1 316 ? -7.265  11.82   -52.165  1    59.163  ? 316  THR A C     1 ? 
ATOM   2553  O  O     . THR A 1 316 ? -6.615  12.305  -53.088  1    56.034  ? 316  THR A O     1 ? 
ATOM   2554  C  CB    . THR A 1 316 ? -9.668  11.084  -52.489  1    51.344  ? 316  THR A CB    1 ? 
ATOM   2555  O  OG1   . THR A 1 316 ? -10.386 9.947   -52.958  1    47.174  ? 316  THR A OG1   1 ? 
ATOM   2556  C  CG2   . THR A 1 316 ? -9.891  12.295  -53.377  1    55.263  ? 316  THR A CG2   1 ? 
ATOM   2557  N  N     . ILE A 1 317 ? -7.184  12.291  -50.915  1    58.268  ? 317  ILE A N     1 ? 
ATOM   2558  C  CA    . ILE A 1 317 ? -6.61   13.616  -50.717  1    51.472  ? 317  ILE A CA    1 ? 
ATOM   2559  C  C     . ILE A 1 317 ? -5.153  13.532  -50.259  1    48.008  ? 317  ILE A C     1 ? 
ATOM   2560  O  O     . ILE A 1 317 ? -4.412  14.511  -50.343  1    44.163  ? 317  ILE A O     1 ? 
ATOM   2561  C  CB    . ILE A 1 317 ? -7.486  14.448  -49.762  1    60.76   ? 317  ILE A CB    1 ? 
ATOM   2562  C  CG1   . ILE A 1 317 ? -7.396  15.942  -50.072  1    57.953  ? 317  ILE A CG1   1 ? 
ATOM   2563  C  CG2   . ILE A 1 317 ? -7.145  14.13   -48.304  1    59.07   ? 317  ILE A CG2   1 ? 
ATOM   2564  C  CD1   . ILE A 1 317 ? -8.478  16.787  -49.431  1    63.699  ? 317  ILE A CD1   1 ? 
ATOM   2565  N  N     . LEU A 1 318 ? -4.739  12.369  -49.751  1    52.957  ? 318  LEU A N     1 ? 
ATOM   2566  C  CA    . LEU A 1 318 ? -3.416  12.3    -49.154  1    55.566  ? 318  LEU A CA    1 ? 
ATOM   2567  C  C     . LEU A 1 318 ? -2.349  12.765  -50.145  1    60.576  ? 318  LEU A C     1 ? 
ATOM   2568  O  O     . LEU A 1 318 ? -1.507  13.593  -49.78   1    64.467  ? 318  LEU A O     1 ? 
ATOM   2569  C  CB    . LEU A 1 318 ? -3.073  10.947  -48.528  1    60.649  ? 318  LEU A CB    1 ? 
ATOM   2570  C  CG    . LEU A 1 318 ? -1.698  10.87   -47.85   1    53.151  ? 318  LEU A CG    1 ? 
ATOM   2571  C  CD1   . LEU A 1 318 ? -1.553  11.959  -46.774  1    53.105  ? 318  LEU A CD1   1 ? 
ATOM   2572  C  CD2   . LEU A 1 318 ? -1.444  9.463   -47.302  1    48.812  ? 318  LEU A CD2   1 ? 
ATOM   2573  N  N     . PRO A 1 319 ? -2.305  12.225  -51.394  1    69.919  ? 319  PRO A N     1 ? 
ATOM   2574  C  CA    . PRO A 1 319 ? -1.335  12.678  -52.4    1    67.784  ? 319  PRO A CA    1 ? 
ATOM   2575  C  C     . PRO A 1 319 ? -1.074  14.18   -52.497  1    70.042  ? 319  PRO A C     1 ? 
ATOM   2576  O  O     . PRO A 1 319 ? 0.073   14.582  -52.686  1    65.802  ? 319  PRO A O     1 ? 
ATOM   2577  C  CB    . PRO A 1 319 ? -1.991  12.118  -53.665  1    69.236  ? 319  PRO A CB    1 ? 
ATOM   2578  C  CG    . PRO A 1 319 ? -2.485  10.76   -53.223  1    63.526  ? 319  PRO A CG    1 ? 
ATOM   2579  C  CD    . PRO A 1 319 ? -3.121  11.09   -51.883  1    64.515  ? 319  PRO A CD    1 ? 
ATOM   2580  N  N     . GLU A 1 320 ? -2.135  14.984  -52.301  1    66.997  ? 320  GLU A N     1 ? 
ATOM   2581  C  CA    . GLU A 1 320 ? -2.115  16.428  -52.485  1    63.166  ? 320  GLU A CA    1 ? 
ATOM   2582  C  C     . GLU A 1 320 ? -1.34   17.125  -51.371  1    67.44   ? 320  GLU A C     1 ? 
ATOM   2583  O  O     . GLU A 1 320 ? -0.926  18.272  -51.535  1    67.019  ? 320  GLU A O     1 ? 
ATOM   2584  C  CB    . GLU A 1 320 ? -3.508  17.054  -52.44   1    59.394  ? 320  GLU A CB    1 ? 
ATOM   2585  C  CG    . GLU A 1 320 ? -4.521  16.395  -53.371  1    69.929  ? 320  GLU A CG    1 ? 
ATOM   2586  C  CD    . GLU A 1 320 ? -5.794  17.215  -53.523  1    79.199  ? 320  GLU A CD    1 ? 
ATOM   2587  O  OE1   . GLU A 1 320 ? -5.757  18.434  -53.236  1    81.783  ? 320  GLU A OE1   1 ? 
ATOM   2588  O  OE2   . GLU A 1 320 ? -6.836  16.638  -53.912  1    73.467  ? 320  GLU A OE2   1 ? 
ATOM   2589  N  N     . LEU A 1 321 ? -1.17   16.453  -50.229  1    56.399  ? 321  LEU A N     1 ? 
ATOM   2590  C  CA    . LEU A 1 321 ? -0.56   17.101  -49.081  1    50.295  ? 321  LEU A CA    1 ? 
ATOM   2591  C  C     . LEU A 1 321 ? 0.939   16.823  -49.101  1    53.219  ? 321  LEU A C     1 ? 
ATOM   2592  O  O     . LEU A 1 321 ? 1.386   15.88   -49.752  1    54.375  ? 321  LEU A O     1 ? 
ATOM   2593  C  CB    . LEU A 1 321 ? -1.228  16.522  -47.835  1    48.682  ? 321  LEU A CB    1 ? 
ATOM   2594  C  CG    . LEU A 1 321 ? -2.741  16.308  -47.939  1    48.394  ? 321  LEU A CG    1 ? 
ATOM   2595  C  CD1   . LEU A 1 321 ? -3.259  15.479  -46.786  1    50.749  ? 321  LEU A CD1   1 ? 
ATOM   2596  C  CD2   . LEU A 1 321 ? -3.458  17.648  -48.012  1    50.971  ? 321  LEU A CD2   1 ? 
ATOM   2597  N  N     . GLY A 1 322 ? 1.699   17.63   -48.352  1    57.205  ? 322  GLY A N     1 ? 
ATOM   2598  C  CA    . GLY A 1 322 ? 3.145   17.477  -48.25   1    62.051  ? 322  GLY A CA    1 ? 
ATOM   2599  C  C     . GLY A 1 322 ? 3.564   16.343  -47.308  1    63.062  ? 322  GLY A C     1 ? 
ATOM   2600  O  O     . GLY A 1 322 ? 4.749   16.002  -47.235  1    59.74   ? 322  GLY A O     1 ? 
ATOM   2601  N  N     . GLY A 1 323 ? 2.588   15.765  -46.589  1    55.415  ? 323  GLY A N     1 ? 
ATOM   2602  C  CA    . GLY A 1 323 ? 2.861   14.732  -45.599  1    54.76   ? 323  GLY A CA    1 ? 
ATOM   2603  C  C     . GLY A 1 323 ? 1.594   14.318  -44.847  1    55.438  ? 323  GLY A C     1 ? 
ATOM   2604  O  O     . GLY A 1 323 ? 0.482   14.412  -45.376  1    47.305  ? 323  GLY A O     1 ? 
ATOM   2605  N  N     . TYR A 1 324 ? 1.779   13.865  -43.601  1    53.217  ? 324  TYR A N     1 ? 
ATOM   2606  C  CA    . TYR A 1 324 ? 0.703   13.228  -42.857  1    46.867  ? 324  TYR A CA    1 ? 
ATOM   2607  C  C     . TYR A 1 324 ? -0.059  14.289  -42.066  1    42.826  ? 324  TYR A C     1 ? 
ATOM   2608  O  O     . TYR A 1 324 ? 0.424   15.408  -41.916  1    44.576  ? 324  TYR A O     1 ? 
ATOM   2609  C  CB    . TYR A 1 324 ? 1.379   12.119  -42.053  1    46.269  ? 324  TYR A CB    1 ? 
ATOM   2610  C  CG    . TYR A 1 324 ? 1.938   10.976  -42.898  1    46.288  ? 324  TYR A CG    1 ? 
ATOM   2611  C  CD1   . TYR A 1 324 ? 1.127   9.926   -43.323  1    44.126  ? 324  TYR A CD1   1 ? 
ATOM   2612  C  CD2   . TYR A 1 324 ? 3.284   10.937  -43.245  1    44.168  ? 324  TYR A CD2   1 ? 
ATOM   2613  C  CE1   . TYR A 1 324 ? 1.643   8.869   -44.061  1    49.469  ? 324  TYR A CE1   1 ? 
ATOM   2614  C  CE2   . TYR A 1 324 ? 3.812   9.884   -43.981  1    44.344  ? 324  TYR A CE2   1 ? 
ATOM   2615  C  CZ    . TYR A 1 324 ? 2.985   8.858   -44.407  1    49.601  ? 324  TYR A CZ    1 ? 
ATOM   2616  O  OH    . TYR A 1 324 ? 3.501   7.831   -45.149  1    51.457  ? 324  TYR A OH    1 ? 
ATOM   2617  N  N     . ILE A 1 325 ? -1.261  13.944  -41.586  1    42.724  ? 325  ILE A N     1 ? 
ATOM   2618  C  CA    . ILE A 1 325 ? -2.121  14.913  -40.912  1    35.799  ? 325  ILE A CA    1 ? 
ATOM   2619  C  C     . ILE A 1 325 ? -1.843  14.892  -39.403  1    39.46   ? 325  ILE A C     1 ? 
ATOM   2620  O  O     . ILE A 1 325 ? -1.696  15.938  -38.764  1    34.992  ? 325  ILE A O     1 ? 
ATOM   2621  C  CB    . ILE A 1 325 ? -3.601  14.62   -41.213  1    37.981  ? 325  ILE A CB    1 ? 
ATOM   2622  C  CG1   . ILE A 1 325 ? -3.875  14.543  -42.73   1    38.786  ? 325  ILE A CG1   1 ? 
ATOM   2623  C  CG2   . ILE A 1 325 ? -4.461  15.685  -40.524  1    39.766  ? 325  ILE A CG2   1 ? 
ATOM   2624  C  CD1   . ILE A 1 325 ? -5.271  14.089  -43.134  1    35.973  ? 325  ILE A CD1   1 ? 
ATOM   2625  N  N     . ASN A 1 326 ? -1.797  13.681  -38.836  1    39.266  ? 326  ASN A N     1 ? 
ATOM   2626  C  CA    . ASN A 1 326 ? -1.433  13.477  -37.439  1    39.357  ? 326  ASN A CA    1 ? 
ATOM   2627  C  C     . ASN A 1 326 ? 0.057   13.133  -37.34   1    36.738  ? 326  ASN A C     1 ? 
ATOM   2628  O  O     . ASN A 1 326 ? 0.463   11.982  -37.489  1    42.954  ? 326  ASN A O     1 ? 
ATOM   2629  C  CB    . ASN A 1 326 ? -2.381  12.469  -36.775  1    31.268  ? 326  ASN A CB    1 ? 
ATOM   2630  C  CG    . ASN A 1 326 ? -1.898  12.02   -35.411  1    30.563  ? 326  ASN A CG    1 ? 
ATOM   2631  O  OD1   . ASN A 1 326 ? -1.2    12.769  -34.717  1    29.242  ? 326  ASN A OD1   1 ? 
ATOM   2632  N  ND2   . ASN A 1 326 ? -2.252  10.808  -35.005  1    28.186  ? 326  ASN A ND2   1 ? 
ATOM   2633  N  N     . GLU A 1 327 ? 0.88    14.137  -37.06   1    36.561  ? 327  GLU A N     1 ? 
ATOM   2634  C  CA    . GLU A 1 327 ? 2.307   13.899  -37.002  1    37.195  ? 327  GLU A CA    1 ? 
ATOM   2635  C  C     . GLU A 1 327 ? 2.689   13.589  -35.559  1    39.049  ? 327  GLU A C     1 ? 
ATOM   2636  O  O     . GLU A 1 327 ? 3.054   14.494  -34.819  1    39.271  ? 327  GLU A O     1 ? 
ATOM   2637  C  CB    . GLU A 1 327 ? 3.119   15.058  -37.579  1    41.771  ? 327  GLU A CB    1 ? 
ATOM   2638  C  CG    . GLU A 1 327 ? 2.617   15.518  -38.95   1    47.69   ? 327  GLU A CG    1 ? 
ATOM   2639  C  CD    . GLU A 1 327 ? 3.448   16.602  -39.625  1    45.225  ? 327  GLU A CD    1 ? 
ATOM   2640  O  OE1   . GLU A 1 327 ? 3.047   17.78   -39.556  1    47.673  ? 327  GLU A OE1   1 ? 
ATOM   2641  O  OE2   . GLU A 1 327 ? 4.477   16.277  -40.246  1    52.779  ? 327  GLU A OE2   1 ? 
ATOM   2642  N  N     . SER A 1 328 ? 2.59    12.299  -35.189  1    35.802  ? 328  SER A N     1 ? 
ATOM   2643  C  CA    . SER A 1 328 ? 2.935   11.801  -33.861  1    36.15   ? 328  SER A CA    1 ? 
ATOM   2644  C  C     . SER A 1 328 ? 2.143   12.498  -32.754  1    32.255  ? 328  SER A C     1 ? 
ATOM   2645  O  O     . SER A 1 328 ? 2.691   12.746  -31.683  1    30.393  ? 328  SER A O     1 ? 
ATOM   2646  C  CB    . SER A 1 328 ? 4.443   11.883  -33.587  1    38.768  ? 328  SER A CB    1 ? 
ATOM   2647  O  OG    . SER A 1 328 ? 5.136   10.915  -34.357  1    40.92   ? 328  SER A OG    1 ? 
ATOM   2648  N  N     . GLY A 1 329 ? 0.86    12.802  -32.992  1    33.624  ? 329  GLY A N     1 ? 
ATOM   2649  C  CA    . GLY A 1 329 ? 0.037   13.427  -31.963  1    31.577  ? 329  GLY A CA    1 ? 
ATOM   2650  C  C     . GLY A 1 329 ? -0.045  14.952  -32.069  1    34.51   ? 329  GLY A C     1 ? 
ATOM   2651  O  O     . GLY A 1 329 ? -0.843  15.566  -31.348  1    33.609  ? 329  GLY A O     1 ? 
ATOM   2652  N  N     . HIS A 1 330 ? 0.75    15.56   -32.964  1    36.115  ? 330  HIS A N     1 ? 
ATOM   2653  C  CA    . HIS A 1 330 ? 0.611   16.983  -33.272  1    34.847  ? 330  HIS A CA    1 ? 
ATOM   2654  C  C     . HIS A 1 330 ? -0.179  17.152  -34.565  1    34.083  ? 330  HIS A C     1 ? 
ATOM   2655  O  O     . HIS A 1 330 ? 0.192   16.644  -35.623  1    36.967  ? 330  HIS A O     1 ? 
ATOM   2656  C  CB    . HIS A 1 330 ? 1.978   17.666  -33.38   1    37.693  ? 330  HIS A CB    1 ? 
ATOM   2657  C  CG    . HIS A 1 330 ? 2.771   17.644  -32.105  1    39.058  ? 330  HIS A CG    1 ? 
ATOM   2658  N  ND1   . HIS A 1 330 ? 3.653   16.625  -31.778  1    42.303  ? 330  HIS A ND1   1 ? 
ATOM   2659  C  CD2   . HIS A 1 330 ? 2.807   18.514  -31.076  1    37.648  ? 330  HIS A CD2   1 ? 
ATOM   2660  C  CE1   . HIS A 1 330 ? 4.208   16.872  -30.6    1    35.578  ? 330  HIS A CE1   1 ? 
ATOM   2661  N  NE2   . HIS A 1 330 ? 3.701   18.019  -30.154  1    41.417  ? 330  HIS A NE2   1 ? 
ATOM   2662  N  N     . LEU A 1 331 ? -1.298  17.866  -34.473  1    30.647  ? 331  LEU A N     1 ? 
ATOM   2663  C  CA    . LEU A 1 331 ? -2.206  18.002  -35.599  1    32.743  ? 331  LEU A CA    1 ? 
ATOM   2664  C  C     . LEU A 1 331 ? -1.613  18.989  -36.614  1    31.602  ? 331  LEU A C     1 ? 
ATOM   2665  O  O     . LEU A 1 331 ? -1.183  20.07   -36.243  1    33.923  ? 331  LEU A O     1 ? 
ATOM   2666  C  CB    . LEU A 1 331 ? -3.548  18.511  -35.068  1    29.749  ? 331  LEU A CB    1 ? 
ATOM   2667  C  CG    . LEU A 1 331 ? -4.674  18.589  -36.096  1    30.125  ? 331  LEU A CG    1 ? 
ATOM   2668  C  CD1   . LEU A 1 331 ? -4.748  17.214  -36.704  1    26.956  ? 331  LEU A CD1   1 ? 
ATOM   2669  C  CD2   . LEU A 1 331 ? -5.993  18.944  -35.451  1    29.094  ? 331  LEU A CD2   1 ? 
ATOM   2670  N  N     . ASN A 1 332 ? -1.584  18.606  -37.895  1    35.672  ? 332  ASN A N     1 ? 
ATOM   2671  C  CA    . ASN A 1 332 ? -1.115  19.519  -38.938  1    36.653  ? 332  ASN A CA    1 ? 
ATOM   2672  C  C     . ASN A 1 332 ? -2.351  20.212  -39.504  1    31.188  ? 332  ASN A C     1 ? 
ATOM   2673  O  O     . ASN A 1 332 ? -3.135  19.621  -40.26   1    38.925  ? 332  ASN A O     1 ? 
ATOM   2674  C  CB    . ASN A 1 332 ? -0.183  18.809  -39.923  1    39.253  ? 332  ASN A CB    1 ? 
ATOM   2675  C  CG    . ASN A 1 332 ? 0.32    19.683  -41.058  1    46.269  ? 332  ASN A CG    1 ? 
ATOM   2676  O  OD1   . ASN A 1 332 ? -0.462  20.374  -41.723  1    38.333  ? 332  ASN A OD1   1 ? 
ATOM   2677  N  ND2   . ASN A 1 332 ? 1.625   19.655  -41.294  1    44.799  ? 332  ASN A ND2   1 ? 
ATOM   2678  N  N     . LEU A 1 333 ? -2.532  21.459  -39.072  1    30.327  ? 333  LEU A N     1 ? 
ATOM   2679  C  CA    . LEU A 1 333 ? -3.775  22.193  -39.247  1    34.037  ? 333  LEU A CA    1 ? 
ATOM   2680  C  C     . LEU A 1 333 ? -4.044  22.464  -40.731  1    38.711  ? 333  LEU A C     1 ? 
ATOM   2681  O  O     . LEU A 1 333 ? -5.179  22.247  -41.189  1    35.914  ? 333  LEU A O     1 ? 
ATOM   2682  C  CB    . LEU A 1 333 ? -3.712  23.483  -38.416  1    38.352  ? 333  LEU A CB    1 ? 
ATOM   2683  C  CG    . LEU A 1 333 ? -4.419  23.509  -37.054  1    40.884  ? 333  LEU A CG    1 ? 
ATOM   2684  C  CD1   . LEU A 1 333 ? -4.399  22.178  -36.37   1    43.494  ? 333  LEU A CD1   1 ? 
ATOM   2685  C  CD2   . LEU A 1 333 ? -3.779  24.534  -36.159  1    37.933  ? 333  LEU A CD2   1 ? 
ATOM   2686  N  N     . PRO A 1 334 ? -3.064  22.991  -41.524  1    38.283  ? 334  PRO A N     1 ? 
ATOM   2687  C  CA    . PRO A 1 334 ? -3.266  23.117  -42.971  1    43.903  ? 334  PRO A CA    1 ? 
ATOM   2688  C  C     . PRO A 1 334 ? -3.774  21.819  -43.608  1    41.218  ? 334  PRO A C     1 ? 
ATOM   2689  O  O     . PRO A 1 334 ? -4.8    21.819  -44.295  1    41.295  ? 334  PRO A O     1 ? 
ATOM   2690  C  CB    . PRO A 1 334 ? -1.912  23.628  -43.529  1    42.971  ? 334  PRO A CB    1 ? 
ATOM   2691  C  CG    . PRO A 1 334 ? -1.265  24.342  -42.337  1    46.139  ? 334  PRO A CG    1 ? 
ATOM   2692  C  CD    . PRO A 1 334 ? -1.775  23.567  -41.099  1    43.097  ? 334  PRO A CD    1 ? 
ATOM   2693  N  N     . ARG A 1 335 ? -3.105  20.693  -43.314  1    40.19   ? 335  ARG A N     1 ? 
ATOM   2694  C  CA    . ARG A 1 335 ? -3.51   19.437  -43.927  1    36.479  ? 335  ARG A CA    1 ? 
ATOM   2695  C  C     . ARG A 1 335 ? -4.888  18.994  -43.429  1    40.508  ? 335  ARG A C     1 ? 
ATOM   2696  O  O     . ARG A 1 335 ? -5.683  18.454  -44.2    1    38.516  ? 335  ARG A O     1 ? 
ATOM   2697  C  CB    . ARG A 1 335 ? -2.429  18.37   -43.745  1    40.734  ? 335  ARG A CB    1 ? 
ATOM   2698  C  CG    . ARG A 1 335 ? -1.077  18.752  -44.336  1    44.456  ? 335  ARG A CG    1 ? 
ATOM   2699  C  CD    . ARG A 1 335 ? -0.075  17.603  -44.297  1    41.792  ? 335  ARG A CD    1 ? 
ATOM   2700  N  NE    . ARG A 1 335 ? 1.283   18.074  -44.608  1    48.897  ? 335  ARG A NE    1 ? 
ATOM   2701  C  CZ    . ARG A 1 335 ? 2.397   17.815  -43.924  1    47.25   ? 335  ARG A CZ    1 ? 
ATOM   2702  N  NH1   . ARG A 1 335 ? 2.41    16.915  -42.955  1    48.927  ? 335  ARG A NH1   1 ? 
ATOM   2703  N  NH2   . ARG A 1 335 ? 3.517   18.433  -44.233  1    45.142  ? 335  ARG A NH2   1 ? 
ATOM   2704  N  N     . PHE A 1 336 ? -5.178  19.213  -42.134  1    35.873  ? 336  PHE A N     1 ? 
ATOM   2705  C  CA    . PHE A 1 336 ? -6.425  18.726  -41.557  1    38.779  ? 336  PHE A CA    1 ? 
ATOM   2706  C  C     . PHE A 1 336 ? -7.586  19.48   -42.211  1    33.196  ? 336  PHE A C     1 ? 
ATOM   2707  O  O     . PHE A 1 336 ? -8.639  18.905  -42.483  1    33.609  ? 336  PHE A O     1 ? 
ATOM   2708  C  CB    . PHE A 1 336 ? -6.405  18.891  -40.022  1    39.906  ? 336  PHE A CB    1 ? 
ATOM   2709  C  CG    . PHE A 1 336 ? -7.54   18.261  -39.222  1    38.845  ? 336  PHE A CG    1 ? 
ATOM   2710  C  CD1   . PHE A 1 336 ? -7.89   16.92   -39.387  1    37.062  ? 336  PHE A CD1   1 ? 
ATOM   2711  C  CD2   . PHE A 1 336 ? -8.27   19.018  -38.303  1    42.572  ? 336  PHE A CD2   1 ? 
ATOM   2712  C  CE1   . PHE A 1 336 ? -8.938  16.357  -38.654  1    36.06   ? 336  PHE A CE1   1 ? 
ATOM   2713  C  CE2   . PHE A 1 336 ? -9.319  18.458  -37.572  1    39.718  ? 336  PHE A CE2   1 ? 
ATOM   2714  C  CZ    . PHE A 1 336 ? -9.64   17.126  -37.739  1    37.386  ? 336  PHE A CZ    1 ? 
ATOM   2715  N  N     . GLU A 1 337 ? -7.365  20.767  -42.473  1    34.51   ? 337  GLU A N     1 ? 
ATOM   2716  C  CA    . GLU A 1 337 ? -8.383  21.626  -43.072  1    40.109  ? 337  GLU A CA    1 ? 
ATOM   2717  C  C     . GLU A 1 337 ? -8.769  21.112  -44.464  1    37.983  ? 337  GLU A C     1 ? 
ATOM   2718  O  O     . GLU A 1 337 ? -9.94   20.819  -44.73   1    35.925  ? 337  GLU A O     1 ? 
ATOM   2719  C  CB    . GLU A 1 337 ? -7.984  23.108  -43.101  1    40.43   ? 337  GLU A CB    1 ? 
ATOM   2720  C  CG    . GLU A 1 337 ? -9.006  23.93   -43.893  1    45.209  ? 337  GLU A CG    1 ? 
ATOM   2721  C  CD    . GLU A 1 337 ? -9.2    25.397  -43.584  1    46.503  ? 337  GLU A CD    1 ? 
ATOM   2722  O  OE1   . GLU A 1 337 ? -8.542  25.917  -42.657  1    48.057  ? 337  GLU A OE1   1 ? 
ATOM   2723  O  OE2   . GLU A 1 337 ? -10.037 26.017  -44.281  1    54.966  ? 337  GLU A OE2   1 ? 
ATOM   2724  N  N     . LYS A 1 338 ? -7.758  20.971  -45.324  1    38.955  ? 338  LYS A N     1 ? 
ATOM   2725  C  CA    . LYS A 1 338 ? -7.927  20.406  -46.655  1    40.095  ? 338  LYS A CA    1 ? 
ATOM   2726  C  C     . LYS A 1 338 ? -8.783  19.15   -46.56   1    34.876  ? 338  LYS A C     1 ? 
ATOM   2727  O  O     . LYS A 1 338 ? -9.808  19.052  -47.231  1    39.241  ? 338  LYS A O     1 ? 
ATOM   2728  C  CB    . LYS A 1 338 ? -6.55   20.243  -47.322  1    44.183  ? 338  LYS A CB    1 ? 
ATOM   2729  C  CG    . LYS A 1 338 ? -5.952  21.598  -47.759  1    53.28   ? 338  LYS A CG    1 ? 
ATOM   2730  C  CD    . LYS A 1 338 ? -4.45   21.715  -48.037  1    69.711  ? 338  LYS A CD    1 ? 
ATOM   2731  C  CE    . LYS A 1 338 ? -3.886  21.05   -49.269  1    84.866  ? 338  LYS A CE    1 ? 
ATOM   2732  N  NZ    . LYS A 1 338 ? -4.077  21.765  -50.539  1    86.011  ? 338  LYS A NZ    1 ? 
ATOM   2733  N  N     . TYR A 1 339 ? -8.389  18.226  -45.673  1    37.355  ? 339  TYR A N     1 ? 
ATOM   2734  C  CA    . TYR A 1 339 ? -9.11   16.973  -45.476  1    38.353  ? 339  TYR A CA    1 ? 
ATOM   2735  C  C     . TYR A 1 339 ? -10.587 17.205  -45.115  1    40.01   ? 339  TYR A C     1 ? 
ATOM   2736  O  O     . TYR A 1 339 ? -11.49  16.615  -45.722  1    39.606  ? 339  TYR A O     1 ? 
ATOM   2737  C  CB    . TYR A 1 339 ? -8.388  16.088  -44.447  1    38.517  ? 339  TYR A CB    1 ? 
ATOM   2738  C  CG    . TYR A 1 339 ? -9.146  14.794  -44.187  1    38.732  ? 339  TYR A CG    1 ? 
ATOM   2739  C  CD1   . TYR A 1 339 ? -9.039  13.708  -45.051  1    41.253  ? 339  TYR A CD1   1 ? 
ATOM   2740  C  CD2   . TYR A 1 339 ? -9.999  14.675  -43.095  1    34.558  ? 339  TYR A CD2   1 ? 
ATOM   2741  C  CE1   . TYR A 1 339 ? -9.749  12.537  -44.832  1    42.301  ? 339  TYR A CE1   1 ? 
ATOM   2742  C  CE2   . TYR A 1 339 ? -10.696 13.506  -42.859  1    37.464  ? 339  TYR A CE2   1 ? 
ATOM   2743  C  CZ    . TYR A 1 339 ? -10.583 12.445  -43.738  1    39.444  ? 339  TYR A CZ    1 ? 
ATOM   2744  O  OH    . TYR A 1 339 ? -11.313 11.333  -43.492  1    38.746  ? 339  TYR A OH    1 ? 
ATOM   2745  N  N     . LEU A 1 340 ? -10.84  18.027  -44.085  1    39.376  ? 340  LEU A N     1 ? 
ATOM   2746  C  CA    . LEU A 1 340 ? -12.204 18.231  -43.618  1    36.398  ? 340  LEU A CA    1 ? 
ATOM   2747  C  C     . LEU A 1 340 ? -13.02  18.835  -44.752  1    37.848  ? 340  LEU A C     1 ? 
ATOM   2748  O  O     . LEU A 1 340 ? -14.146 18.402  -44.984  1    36.696  ? 340  LEU A O     1 ? 
ATOM   2749  C  CB    . LEU A 1 340 ? -12.294 19.116  -42.37   1    35.499  ? 340  LEU A CB    1 ? 
ATOM   2750  C  CG    . LEU A 1 340 ? -11.65  18.543  -41.101  1    34.84   ? 340  LEU A CG    1 ? 
ATOM   2751  C  CD1   . LEU A 1 340 ? -11.707 19.512  -39.942  1    33.177  ? 340  LEU A CD1   1 ? 
ATOM   2752  C  CD2   . LEU A 1 340 ? -12.276 17.203  -40.765  1    34.962  ? 340  LEU A CD2   1 ? 
ATOM   2753  N  N     . VAL A 1 341 ? -12.435 19.831  -45.434  1    37.625  ? 341  VAL A N     1 ? 
ATOM   2754  C  CA    . VAL A 1 341 ? -13.114 20.533  -46.522  1    40.98   ? 341  VAL A CA    1 ? 
ATOM   2755  C  C     . VAL A 1 341 ? -13.631 19.515  -47.541  1    40.272  ? 341  VAL A C     1 ? 
ATOM   2756  O  O     . VAL A 1 341 ? -14.815 19.511  -47.839  1    42.751  ? 341  VAL A O     1 ? 
ATOM   2757  C  CB    . VAL A 1 341 ? -12.324 21.697  -47.163  1    39.71   ? 341  VAL A CB    1 ? 
ATOM   2758  C  CG1   . VAL A 1 341 ? -12.927 22.156  -48.499  1    39.804  ? 341  VAL A CG1   1 ? 
ATOM   2759  C  CG2   . VAL A 1 341 ? -12.219 22.881  -46.2    1    40.2    ? 341  VAL A CG2   1 ? 
ATOM   2760  N  N     . LYS A 1 342 ? -12.763 18.607  -48.004  1    43.775  ? 342  LYS A N     1 ? 
ATOM   2761  C  CA    . LYS A 1 342 ? -13.173 17.568  -48.941  1    43.219  ? 342  LYS A CA    1 ? 
ATOM   2762  C  C     . LYS A 1 342 ? -14.3   16.725  -48.341  1    48.317  ? 342  LYS A C     1 ? 
ATOM   2763  O  O     . LYS A 1 342 ? -15.285 16.418  -49.017  1    41.98   ? 342  LYS A O     1 ? 
ATOM   2764  C  CB    . LYS A 1 342 ? -11.973 16.702  -49.347  1    52.482  ? 342  LYS A CB    1 ? 
ATOM   2765  C  CG    . LYS A 1 342 ? -12.234 15.576  -50.352  1    55.371  ? 342  LYS A CG    1 ? 
ATOM   2766  C  CD    . LYS A 1 342 ? -12.49  16.049  -51.78   1    65.469  ? 342  LYS A CD    1 ? 
ATOM   2767  C  CE    . LYS A 1 342 ? -13.279 15.012  -52.518  1    75.144  ? 342  LYS A CE    1 ? 
ATOM   2768  N  NZ    . LYS A 1 342 ? -13.878 15.504  -53.762  1    68.859  ? 342  LYS A NZ    1 ? 
ATOM   2769  N  N     . LEU A 1 343 ? -14.174 16.374  -47.052  1    40.223  ? 343  LEU A N     1 ? 
ATOM   2770  C  CA    . LEU A 1 343 ? -15.099 15.425  -46.453  1    36.234  ? 343  LEU A CA    1 ? 
ATOM   2771  C  C     . LEU A 1 343 ? -16.493 16.042  -46.367  1    35.239  ? 343  LEU A C     1 ? 
ATOM   2772  O  O     . LEU A 1 343 ? -17.505 15.343  -46.426  1    37.098  ? 343  LEU A O     1 ? 
ATOM   2773  C  CB    . LEU A 1 343 ? -14.529 15.09   -45.073  1    39.277  ? 343  LEU A CB    1 ? 
ATOM   2774  C  CG    . LEU A 1 343 ? -15.203 13.957  -44.297  1    41.873  ? 343  LEU A CG    1 ? 
ATOM   2775  C  CD1   . LEU A 1 343 ? -15.094 12.634  -45.067  1    42.089  ? 343  LEU A CD1   1 ? 
ATOM   2776  C  CD2   . LEU A 1 343 ? -14.561 13.863  -42.916  1    37.702  ? 343  LEU A CD2   1 ? 
ATOM   2777  N  N     . SER A 1 344 ? -16.516 17.367  -46.271  1    34.904  ? 344  SER A N     1 ? 
ATOM   2778  C  CA    A SER A 1 344 ? -17.725 18.15   -46.079  0.5  40.587  ? 344  SER A CA    1 ? 
ATOM   2779  C  CA    B SER A 1 344 ? -17.738 18.123  -46.06   0.5  38.647  ? 344  SER A CA    1 ? 
ATOM   2780  C  C     . SER A 1 344 ? -18.73  17.925  -47.208  1    41.124  ? 344  SER A C     1 ? 
ATOM   2781  O  O     . SER A 1 344 ? -19.934 18.113  -47.021  1    41.341  ? 344  SER A O     1 ? 
ATOM   2782  C  CB    A SER A 1 344 ? -17.394 19.609  -45.961  0.5  42.267  ? 344  SER A CB    1 ? 
ATOM   2783  C  CB    B SER A 1 344 ? -17.456 19.588  -45.798  0.5  37.278  ? 344  SER A CB    1 ? 
ATOM   2784  O  OG    A SER A 1 344 ? -16.271 19.784  -45.112  0.5  41.258  ? 344  SER A OG    1 ? 
ATOM   2785  O  OG    B SER A 1 344 ? -17.134 20.306  -46.984  0.5  31.492  ? 344  SER A OG    1 ? 
ATOM   2786  N  N     . ASP A 1 345 ? -18.245 17.533  -48.387  1    41.114  ? 345  ASP A N     1 ? 
ATOM   2787  C  CA    . ASP A 1 345 ? -19.178 17.262  -49.47   1    45.874  ? 345  ASP A CA    1 ? 
ATOM   2788  C  C     . ASP A 1 345 ? -20.304 16.367  -48.959  1    47.224  ? 345  ASP A C     1 ? 
ATOM   2789  O  O     . ASP A 1 345 ? -21.413 16.391  -49.496  1    52.821  ? 345  ASP A O     1 ? 
ATOM   2790  C  CB    . ASP A 1 345 ? -18.507 16.571  -50.644  1    52.856  ? 345  ASP A CB    1 ? 
ATOM   2791  C  CG    . ASP A 1 345 ? -17.418 17.368  -51.347  1    55.814  ? 345  ASP A CG    1 ? 
ATOM   2792  O  OD1   . ASP A 1 345 ? -17.43  18.625  -51.249  1    58.429  ? 345  ASP A OD1   1 ? 
ATOM   2793  O  OD2   . ASP A 1 345 ? -16.541 16.714  -51.948  1    60.787  ? 345  ASP A OD2   1 ? 
ATOM   2794  N  N     . PHE A 1 346 ? -19.986 15.547  -47.949  1    41.732  ? 346  PHE A N     1 ? 
ATOM   2795  C  CA    . PHE A 1 346 ? -20.953 14.728  -47.228  1    45.716  ? 346  PHE A CA    1 ? 
ATOM   2796  C  C     . PHE A 1 346 ? -22.171 15.544  -46.785  1    43.568  ? 346  PHE A C     1 ? 
ATOM   2797  O  O     . PHE A 1 346 ? -23.302 15.048  -46.794  1    43.22   ? 346  PHE A O     1 ? 
ATOM   2798  C  CB    . PHE A 1 346 ? -20.194 14.151  -46.023  1    56.628  ? 346  PHE A CB    1 ? 
ATOM   2799  C  CG    . PHE A 1 346 ? -21.014 13.505  -44.911  1    75.338  ? 346  PHE A CG    1 ? 
ATOM   2800  C  CD1   . PHE A 1 346 ? -22.116 12.694  -45.197  1    85.317  ? 346  PHE A CD1   1 ? 
ATOM   2801  C  CD2   . PHE A 1 346 ? -20.677 13.711  -43.574  1    81.465  ? 346  PHE A CD2   1 ? 
ATOM   2802  C  CE1   . PHE A 1 346 ? -22.861 12.115  -44.178  1    88.555  ? 346  PHE A CE1   1 ? 
ATOM   2803  C  CE2   . PHE A 1 346 ? -21.419 13.122  -42.557  1    87.53   ? 346  PHE A CE2   1 ? 
ATOM   2804  C  CZ    . PHE A 1 346 ? -22.504 12.325  -42.861  1    87.084  ? 346  PHE A CZ    1 ? 
ATOM   2805  N  N     . ASP A 1 347 ? -21.949 16.793  -46.353  1    43.382  ? 347  ASP A N     1 ? 
ATOM   2806  C  CA    . ASP A 1 347 ? -23.029 17.572  -45.758  1    40.69   ? 347  ASP A CA    1 ? 
ATOM   2807  C  C     . ASP A 1 347 ? -24.047 17.953  -46.825  1    44.261  ? 347  ASP A C     1 ? 
ATOM   2808  O  O     . ASP A 1 347 ? -25.247 17.925  -46.564  1    42.696  ? 347  ASP A O     1 ? 
ATOM   2809  C  CB    . ASP A 1 347 ? -22.537 18.818  -45.033  1    38.857  ? 347  ASP A CB    1 ? 
ATOM   2810  C  CG    . ASP A 1 347 ? -21.904 18.579  -43.665  1    39.922  ? 347  ASP A CG    1 ? 
ATOM   2811  O  OD1   . ASP A 1 347 ? -21.945 17.412  -43.19   1    45.151  ? 347  ASP A OD1   1 ? 
ATOM   2812  O  OD2   . ASP A 1 347 ? -21.363 19.545  -43.096  1    37.761  ? 347  ASP A OD2   1 ? 
ATOM   2813  N  N     . ARG A 1 348 ? -23.555 18.331  -48.015  1    47.947  ? 348  ARG A N     1 ? 
ATOM   2814  C  CA    . ARG A 1 348 ? -24.465 18.829  -49.036  1    53.88   ? 348  ARG A CA    1 ? 
ATOM   2815  C  C     . ARG A 1 348 ? -25.334 17.682  -49.561  1    56.072  ? 348  ARG A C     1 ? 
ATOM   2816  O  O     . ARG A 1 348 ? -26.548 17.839  -49.702  1    63.856  ? 348  ARG A O     1 ? 
ATOM   2817  C  CB    . ARG A 1 348 ? -23.733 19.724  -50.043  1    58.021  ? 348  ARG A CB    1 ? 
ATOM   2818  C  CG    . ARG A 1 348 ? -23.512 21.092  -49.415  1    64.717  ? 348  ARG A CG    1 ? 
ATOM   2819  C  CD    . ARG A 1 348 ? -22.971 22.177  -50.328  1    66.97   ? 348  ARG A CD    1 ? 
ATOM   2820  N  NE    . ARG A 1 348 ? -22.877 23.478  -49.653  1    64.352  ? 348  ARG A NE    1 ? 
ATOM   2821  C  CZ    . ARG A 1 348 ? -21.892 23.94   -48.865  1    68.462  ? 348  ARG A CZ    1 ? 
ATOM   2822  N  NH1   . ARG A 1 348 ? -20.778 23.248  -48.637  1    53.523  ? 348  ARG A NH1   1 ? 
ATOM   2823  N  NH2   . ARG A 1 348 ? -22.031 25.135  -48.315  1    71.081  ? 348  ARG A NH2   1 ? 
ATOM   2824  N  N     . GLU A 1 349 ? -24.714 16.514  -49.78   1    51.057  ? 349  GLU A N     1 ? 
ATOM   2825  C  CA    . GLU A 1 349 ? -25.427 15.318  -50.192  1    51.727  ? 349  GLU A CA    1 ? 
ATOM   2826  C  C     . GLU A 1 349 ? -26.538 15.002  -49.199  1    51.64   ? 349  GLU A C     1 ? 
ATOM   2827  O  O     . GLU A 1 349 ? -27.681 14.764  -49.605  1    42.272  ? 349  GLU A O     1 ? 
ATOM   2828  C  CB    . GLU A 1 349 ? -24.501 14.106  -50.228  1    70.894  ? 349  GLU A CB    1 ? 
ATOM   2829  C  CG    . GLU A 1 349 ? -23.478 14.143  -51.358  1    88.535  ? 349  GLU A CG    1 ? 
ATOM   2830  C  CD    . GLU A 1 349 ? -22.551 12.957  -51.178  1    105.812 ? 349  GLU A CD    1 ? 
ATOM   2831  O  OE1   . GLU A 1 349 ? -23.053 11.83   -50.916  1    100.471 ? 349  GLU A OE1   1 ? 
ATOM   2832  O  OE2   . GLU A 1 349 ? -21.324 13.176  -51.29   1    110.658 ? 349  GLU A OE2   1 ? 
ATOM   2833  N  N     . HIS A 1 350 ? -26.193 14.971  -47.901  1    45.265  ? 350  HIS A N     1 ? 
ATOM   2834  C  CA    . HIS A 1 350 ? -27.201 14.668  -46.902  1    43.147  ? 350  HIS A CA    1 ? 
ATOM   2835  C  C     . HIS A 1 350 ? -28.335 15.681  -47.027  1    49.278  ? 350  HIS A C     1 ? 
ATOM   2836  O  O     . HIS A 1 350 ? -29.509 15.302  -47.005  1    53.178  ? 350  HIS A O     1 ? 
ATOM   2837  C  CB    . HIS A 1 350 ? -26.627 14.56   -45.482  1    49.695  ? 350  HIS A CB    1 ? 
ATOM   2838  C  CG    . HIS A 1 350 ? -27.743 14.4    -44.494  1    56.703  ? 350  HIS A CG    1 ? 
ATOM   2839  N  ND1   . HIS A 1 350 ? -28.227 13.171  -44.093  1    61.965  ? 350  HIS A ND1   1 ? 
ATOM   2840  C  CD2   . HIS A 1 350 ? -28.522 15.319  -43.886  1    58.023  ? 350  HIS A CD2   1 ? 
ATOM   2841  C  CE1   . HIS A 1 350 ? -29.251 13.349  -43.262  1    61.732  ? 350  HIS A CE1   1 ? 
ATOM   2842  N  NE2   . HIS A 1 350 ? -29.45  14.646  -43.125  1    62.251  ? 350  HIS A NE2   1 ? 
ATOM   2843  N  N     . PHE A 1 351 ? -27.983 16.968  -47.168  1    45.349  ? 351  PHE A N     1 ? 
ATOM   2844  C  CA    . PHE A 1 351 ? -29     18.017  -47.217  1    51.193  ? 351  PHE A CA    1 ? 
ATOM   2845  C  C     . PHE A 1 351 ? -29.837 17.94   -48.504  1    55.524  ? 351  PHE A C     1 ? 
ATOM   2846  O  O     . PHE A 1 351 ? -31.052 18.152  -48.45   1    50.507  ? 351  PHE A O     1 ? 
ATOM   2847  C  CB    . PHE A 1 351 ? -28.393 19.415  -47.024  1    50.751  ? 351  PHE A CB    1 ? 
ATOM   2848  C  CG    . PHE A 1 351 ? -29.365 20.56   -47.271  1    49.293  ? 351  PHE A CG    1 ? 
ATOM   2849  C  CD1   . PHE A 1 351 ? -30.342 20.88   -46.335  1    47.373  ? 351  PHE A CD1   1 ? 
ATOM   2850  C  CD2   . PHE A 1 351 ? -29.307 21.309  -48.445  1    52.725  ? 351  PHE A CD2   1 ? 
ATOM   2851  C  CE1   . PHE A 1 351 ? -31.249 21.902  -46.581  1    50.469  ? 351  PHE A CE1   1 ? 
ATOM   2852  C  CE2   . PHE A 1 351 ? -30.203 22.342  -48.677  1    46.392  ? 351  PHE A CE2   1 ? 
ATOM   2853  C  CZ    . PHE A 1 351 ? -31.165 22.642  -47.737  1    51.281  ? 351  PHE A CZ    1 ? 
ATOM   2854  N  N     . SER A 1 352 ? -29.188 17.656  -49.654  1    60.143  ? 352  SER A N     1 ? 
ATOM   2855  C  CA    . SER A 1 352 ? -29.872 17.585  -50.942  1    65.536  ? 352  SER A CA    1 ? 
ATOM   2856  C  C     . SER A 1 352 ? -30.936 16.487  -50.954  1    65.608  ? 352  SER A C     1 ? 
ATOM   2857  O  O     . SER A 1 352 ? -31.925 16.592  -51.68   1    70.933  ? 352  SER A O     1 ? 
ATOM   2858  C  CB    . SER A 1 352 ? -28.924 17.49   -52.12   1    69.376  ? 352  SER A CB    1 ? 
ATOM   2859  O  OG    . SER A 1 352 ? -28.413 16.18   -52.302  1    76.477  ? 352  SER A OG    1 ? 
ATOM   2860  N  N     . GLU A 1 353 ? -30.742 15.46   -50.116  1    67.691  ? 353  GLU A N     1 ? 
ATOM   2861  C  CA    . GLU A 1 353 ? -31.791 14.496  -49.822  1    70.972  ? 353  GLU A CA    1 ? 
ATOM   2862  C  C     . GLU A 1 353 ? -33.034 15.274  -49.396  1    73.281  ? 353  GLU A C     1 ? 
ATOM   2863  O  O     . GLU A 1 353 ? -34.008 15.316  -50.14   1    83.898  ? 353  GLU A O     1 ? 
ATOM   2864  C  CB    . GLU A 1 353 ? -31.311 13.424  -48.836  1    67.205  ? 353  GLU A CB    1 ? 
ATOM   2865  C  CG    . GLU A 1 353 ? -32.132 12.136  -48.855  1    71.272  ? 353  GLU A CG    1 ? 
ATOM   2866  C  CD    . GLU A 1 353 ? -31.47  10.882  -48.291  1    76.961  ? 353  GLU A CD    1 ? 
ATOM   2867  O  OE1   . GLU A 1 353 ? -32.16  9.843   -48.202  1    79.645  ? 353  GLU A OE1   1 ? 
ATOM   2868  O  OE2   . GLU A 1 353 ? -30.266 10.922  -47.951  1    75.821  ? 353  GLU A OE2   1 ? 
ATOM   2869  N  N     . VAL A 1 354 ? -32.959 15.936  -48.232  1    86.572  ? 354  VAL A N     1 ? 
ATOM   2870  C  CA    . VAL A 1 354 ? -34.045 16.751  -47.697  1    82.181  ? 354  VAL A CA    1 ? 
ATOM   2871  C  C     . VAL A 1 354 ? -34.146 18.061  -48.503  1    76.778  ? 354  VAL A C     1 ? 
ATOM   2872  O  O     . VAL A 1 354 ? -35.27  18.386  -48.936  1    74.028  ? 354  VAL A O     1 ? 
ATOM   2873  C  CB    . VAL A 1 354 ? -33.834 17.048  -46.201  1    75.138  ? 354  VAL A CB    1 ? 
ATOM   2874  C  CG1   . VAL A 1 354 ? -35.103 17.584  -45.557  1    80.968  ? 354  VAL A CG1   1 ? 
ATOM   2875  C  CG2   . VAL A 1 354 ? -33.328 15.829  -45.443  1    76.46   ? 354  VAL A CG2   1 ? 
ATOM   2876  N  N     . ASP A 1 424 ? -27.753 28.318  -56.357  1    84.262  ? 424  ASP A N     1 ? 
ATOM   2877  C  CA    . ASP A 1 424 ? -27.299 29.193  -55.237  1    89.237  ? 424  ASP A CA    1 ? 
ATOM   2878  C  C     . ASP A 1 424 ? -28.431 29.373  -54.227  1    83.711  ? 424  ASP A C     1 ? 
ATOM   2879  O  O     . ASP A 1 424 ? -28.171 29.737  -53.081  1    83.899  ? 424  ASP A O     1 ? 
ATOM   2880  C  CB    . ASP A 1 424 ? -26.706 30.512  -55.719  1    94.745  ? 424  ASP A CB    1 ? 
ATOM   2881  C  CG    . ASP A 1 424 ? -27.677 31.657  -55.991  1    94.157  ? 424  ASP A CG    1 ? 
ATOM   2882  O  OD1   . ASP A 1 424 ? -28.9   31.408  -56.006  1    89.225  ? 424  ASP A OD1   1 ? 
ATOM   2883  O  OD2   . ASP A 1 424 ? -27.204 32.805  -56.17   1    91.78   ? 424  ASP A OD2   1 ? 
ATOM   2884  N  N     . LEU A 1 425 ? -29.68  29.145  -54.664  1    72.256  ? 425  LEU A N     1 ? 
ATOM   2885  C  CA    . LEU A 1 425 ? -30.803 29.019  -53.741  1    72.798  ? 425  LEU A CA    1 ? 
ATOM   2886  C  C     . LEU A 1 425 ? -30.489 27.913  -52.732  1    80.259  ? 425  LEU A C     1 ? 
ATOM   2887  O  O     . LEU A 1 425 ? -30.851 28.01   -51.559  1    83.639  ? 425  LEU A O     1 ? 
ATOM   2888  C  CB    . LEU A 1 425 ? -32.15  28.76   -54.425  1    68.793  ? 425  LEU A CB    1 ? 
ATOM   2889  C  CG    . LEU A 1 425 ? -33.315 28.384  -53.496  1    67.835  ? 425  LEU A CG    1 ? 
ATOM   2890  C  CD1   . LEU A 1 425 ? -33.685 29.524  -52.55   1    73.289  ? 425  LEU A CD1   1 ? 
ATOM   2891  C  CD2   . LEU A 1 425 ? -34.567 27.849  -54.187  1    64.466  ? 425  LEU A CD2   1 ? 
ATOM   2892  N  N     . PHE A 1 426 ? -29.814 26.865  -53.216  1    73.083  ? 426  PHE A N     1 ? 
ATOM   2893  C  CA    . PHE A 1 426 ? -29.44  25.714  -52.413  1    78.531  ? 426  PHE A CA    1 ? 
ATOM   2894  C  C     . PHE A 1 426 ? -28.554 26.155  -51.244  1    75.468  ? 426  PHE A C     1 ? 
ATOM   2895  O  O     . PHE A 1 426 ? -28.848 25.818  -50.099  1    68.806  ? 426  PHE A O     1 ? 
ATOM   2896  C  CB    . PHE A 1 426 ? -28.858 24.693  -53.397  1    82.008  ? 426  PHE A CB    1 ? 
ATOM   2897  C  CG    . PHE A 1 426 ? -28.228 23.445  -52.792  1    83.575  ? 426  PHE A CG    1 ? 
ATOM   2898  C  CD1   . PHE A 1 426 ? -29.013 22.355  -52.428  1    79.357  ? 426  PHE A CD1   1 ? 
ATOM   2899  C  CD2   . PHE A 1 426 ? -26.847 23.36   -52.613  1    86.201  ? 426  PHE A CD2   1 ? 
ATOM   2900  C  CE1   . PHE A 1 426 ? -28.435 21.219  -51.885  1    85.971  ? 426  PHE A CE1   1 ? 
ATOM   2901  C  CE2   . PHE A 1 426 ? -26.272 22.223  -52.07   1    83.596  ? 426  PHE A CE2   1 ? 
ATOM   2902  C  CZ    . PHE A 1 426 ? -27.068 21.156  -51.708  1    90.712  ? 426  PHE A CZ    1 ? 
ATOM   2903  N  N     . GLU A 1 427 ? -27.499 26.933  -51.531  1    72.062  ? 427  GLU A N     1 ? 
ATOM   2904  C  CA    . GLU A 1 427 ? -26.561 27.401  -50.519  1    69.789  ? 427  GLU A CA    1 ? 
ATOM   2905  C  C     . GLU A 1 427 ? -27.286 28.181  -49.424  1    72.959  ? 427  GLU A C     1 ? 
ATOM   2906  O  O     . GLU A 1 427 ? -26.914 28.115  -48.249  1    68.366  ? 427  GLU A O     1 ? 
ATOM   2907  C  CB    . GLU A 1 427 ? -25.475 28.282  -51.131  1    68.532  ? 427  GLU A CB    1 ? 
ATOM   2908  C  CG    . GLU A 1 427 ? -24.418 27.475  -51.877  1    82.665  ? 427  GLU A CG    1 ? 
ATOM   2909  C  CD    . GLU A 1 427 ? -23.839 26.384  -50.996  1    92.482  ? 427  GLU A CD    1 ? 
ATOM   2910  O  OE1   . GLU A 1 427 ? -23.344 26.723  -49.891  1    82.709  ? 427  GLU A OE1   1 ? 
ATOM   2911  O  OE2   . GLU A 1 427 ? -23.904 25.202  -51.416  1    94.407  ? 427  GLU A OE2   1 ? 
ATOM   2912  N  N     . THR A 1 428 ? -28.326 28.914  -49.834  1    64.206  ? 428  THR A N     1 ? 
ATOM   2913  C  CA    . THR A 1 428 ? -29.058 29.789  -48.939  1    61.098  ? 428  THR A CA    1 ? 
ATOM   2914  C  C     . THR A 1 428 ? -29.908 28.933  -48.008  1    55.709  ? 428  THR A C     1 ? 
ATOM   2915  O  O     . THR A 1 428 ? -30     29.225  -46.818  1    67.582  ? 428  THR A O     1 ? 
ATOM   2916  C  CB    . THR A 1 428 ? -29.86  30.821  -49.744  1    62.461  ? 428  THR A CB    1 ? 
ATOM   2917  O  OG1   . THR A 1 428 ? -28.854 31.74   -50.172  1    56.585  ? 428  THR A OG1   1 ? 
ATOM   2918  C  CG2   . THR A 1 428 ? -30.934 31.528  -48.93   1    57.293  ? 428  THR A CG2   1 ? 
ATOM   2919  N  N     . GLU A 1 429 ? -30.511 27.881  -48.561  1    48.615  ? 429  GLU A N     1 ? 
ATOM   2920  C  CA    . GLU A 1 429 ? -31.408 27.013  -47.809  1    54.01   ? 429  GLU A CA    1 ? 
ATOM   2921  C  C     . GLU A 1 429 ? -30.61  26.133  -46.839  1    42.938  ? 429  GLU A C     1 ? 
ATOM   2922  O  O     . GLU A 1 429 ? -31.065 25.842  -45.732  1    44.578  ? 429  GLU A O     1 ? 
ATOM   2923  C  CB    . GLU A 1 429 ? -32.255 26.169  -48.764  1    63.864  ? 429  GLU A CB    1 ? 
ATOM   2924  C  CG    . GLU A 1 429 ? -33.292 26.993  -49.521  1    77.842  ? 429  GLU A CG    1 ? 
ATOM   2925  C  CD    . GLU A 1 429 ? -34.228 27.679  -48.545  1    88.998  ? 429  GLU A CD    1 ? 
ATOM   2926  O  OE1   . GLU A 1 429 ? -35.193 27.033  -48.076  1    84.505  ? 429  GLU A OE1   1 ? 
ATOM   2927  O  OE2   . GLU A 1 429 ? -33.95  28.855  -48.218  1    99.251  ? 429  GLU A OE2   1 ? 
ATOM   2928  N  N     . PHE A 1 430 ? -29.417 25.74   -47.28   1    37.489  ? 430  PHE A N     1 ? 
ATOM   2929  C  CA    . PHE A 1 430 ? -28.493 24.92   -46.528  1    44.162  ? 430  PHE A CA    1 ? 
ATOM   2930  C  C     . PHE A 1 430 ? -28.092 25.712  -45.288  1    51.863  ? 430  PHE A C     1 ? 
ATOM   2931  O  O     . PHE A 1 430 ? -28.118 25.181  -44.177  1    61.19   ? 430  PHE A O     1 ? 
ATOM   2932  C  CB    . PHE A 1 430 ? -27.267 24.698  -47.418  1    45.069  ? 430  PHE A CB    1 ? 
ATOM   2933  C  CG    . PHE A 1 430 ? -26.196 23.769  -46.866  1    46.989  ? 430  PHE A CG    1 ? 
ATOM   2934  C  CD1   . PHE A 1 430 ? -26.542 22.607  -46.172  1    48.347  ? 430  PHE A CD1   1 ? 
ATOM   2935  C  CD2   . PHE A 1 430 ? -24.851 24.057  -47.054  1    41.267  ? 430  PHE A CD2   1 ? 
ATOM   2936  C  CE1   . PHE A 1 430 ? -25.559 21.762  -45.666  1    44.014  ? 430  PHE A CE1   1 ? 
ATOM   2937  C  CE2   . PHE A 1 430 ? -23.879 23.202  -46.562  1    42.907  ? 430  PHE A CE2   1 ? 
ATOM   2938  C  CZ    . PHE A 1 430 ? -24.233 22.064  -45.867  1    40.401  ? 430  PHE A CZ    1 ? 
ATOM   2939  N  N     . ARG A 1 431 ? -27.761 26.993  -45.495  1    43.519  ? 431  ARG A N     1 ? 
ATOM   2940  C  CA    . ARG A 1 431 ? -27.322 27.859  -44.417  1    42.336  ? 431  ARG A CA    1 ? 
ATOM   2941  C  C     . ARG A 1 431 ? -28.428 27.983  -43.364  1    47.297  ? 431  ARG A C     1 ? 
ATOM   2942  O  O     . ARG A 1 431 ? -28.129 28.083  -42.172  1    48.762  ? 431  ARG A O     1 ? 
ATOM   2943  C  CB    . ARG A 1 431 ? -26.625 29.115  -44.963  1    46.247  ? 431  ARG A CB    1 ? 
ATOM   2944  C  CG    . ARG A 1 431 ? -26.204 30.198  -43.971  1    42.973  ? 431  ARG A CG    1 ? 
ATOM   2945  C  CD    . ARG A 1 431 ? -25.343 29.715  -42.796  1    48.066  ? 431  ARG A CD    1 ? 
ATOM   2946  N  NE    . ARG A 1 431 ? -25.028 30.845  -41.906  1    47.937  ? 431  ARG A NE    1 ? 
ATOM   2947  C  CZ    . ARG A 1 431 ? -23.933 31.604  -41.931  1    43.046  ? 431  ARG A CZ    1 ? 
ATOM   2948  N  NH1   . ARG A 1 431 ? -22.977 31.364  -42.818  1    37.22   ? 431  ARG A NH1   1 ? 
ATOM   2949  N  NH2   . ARG A 1 431 ? -23.798 32.601  -41.06   1    36.967  ? 431  ARG A NH2   1 ? 
ATOM   2950  N  N     . GLN A 1 432 ? -29.696 27.888  -43.793  1    42.603  ? 432  GLN A N     1 ? 
ATOM   2951  C  CA    . GLN A 1 432 ? -30.825 28.132  -42.911  1    41.049  ? 432  GLN A CA    1 ? 
ATOM   2952  C  C     . GLN A 1 432 ? -31.183 26.854  -42.176  1    41.888  ? 432  GLN A C     1 ? 
ATOM   2953  O  O     . GLN A 1 432 ? -31.641 26.919  -41.032  1    38.064  ? 432  GLN A O     1 ? 
ATOM   2954  C  CB    . GLN A 1 432 ? -32.106 28.606  -43.598  1    50.728  ? 432  GLN A CB    1 ? 
ATOM   2955  C  CG    . GLN A 1 432 ? -32.001 30.006  -44.192  1    65.255  ? 432  GLN A CG    1 ? 
ATOM   2956  C  CD    . GLN A 1 432 ? -33.332 30.584  -44.628  1    74.225  ? 432  GLN A CD    1 ? 
ATOM   2957  O  OE1   . GLN A 1 432 ? -34.225 29.88   -45.123  1    73.566  ? 432  GLN A OE1   1 ? 
ATOM   2958  N  NE2   . GLN A 1 432 ? -33.475 31.888  -44.436  1    79.908  ? 432  GLN A NE2   1 ? 
ATOM   2959  N  N     . TYR A 1 433 ? -31.011 25.73   -42.887  1    40.037  ? 433  TYR A N     1 ? 
ATOM   2960  C  CA    . TYR A 1 433 ? -30.954 24.383  -42.336  1    43.086  ? 433  TYR A CA    1 ? 
ATOM   2961  C  C     . TYR A 1 433 ? -29.97  24.37   -41.161  1    43.317  ? 433  TYR A C     1 ? 
ATOM   2962  O  O     . TYR A 1 433 ? -30.385 24.165  -40.024  1    44.559  ? 433  TYR A O     1 ? 
ATOM   2963  C  CB    . TYR A 1 433 ? -30.562 23.431  -43.477  1    50.026  ? 433  TYR A CB    1 ? 
ATOM   2964  C  CG    . TYR A 1 433 ? -30.183 22.005  -43.091  1    51.256  ? 433  TYR A CG    1 ? 
ATOM   2965  C  CD1   . TYR A 1 433 ? -31.163 21.075  -42.75   1    51.046  ? 433  TYR A CD1   1 ? 
ATOM   2966  C  CD2   . TYR A 1 433 ? -28.855 21.582  -43.097  1    48.559  ? 433  TYR A CD2   1 ? 
ATOM   2967  C  CE1   . TYR A 1 433 ? -30.832 19.775  -42.402  1    52.414  ? 433  TYR A CE1   1 ? 
ATOM   2968  C  CE2   . TYR A 1 433 ? -28.511 20.285  -42.745  1    47.501  ? 433  TYR A CE2   1 ? 
ATOM   2969  C  CZ    . TYR A 1 433 ? -29.504 19.385  -42.393  1    47.884  ? 433  TYR A CZ    1 ? 
ATOM   2970  O  OH    . TYR A 1 433 ? -29.213 18.104  -42.028  1    51.096  ? 433  TYR A OH    1 ? 
ATOM   2971  N  N     . LYS A 1 434 ? -28.695 24.665  -41.443  1    37.495  ? 434  LYS A N     1 ? 
ATOM   2972  C  CA    . LYS A 1 434 ? -27.631 24.692  -40.442  1    44.764  ? 434  LYS A CA    1 ? 
ATOM   2973  C  C     . LYS A 1 434 ? -27.942 25.675  -39.316  1    47.128  ? 434  LYS A C     1 ? 
ATOM   2974  O  O     . LYS A 1 434 ? -27.75  25.354  -38.144  1    52.435  ? 434  LYS A O     1 ? 
ATOM   2975  C  CB    . LYS A 1 434 ? -26.288 25.04   -41.087  1    39.367  ? 434  LYS A CB    1 ? 
ATOM   2976  C  CG    . LYS A 1 434 ? -25.796 23.99   -42.088  1    44.734  ? 434  LYS A CG    1 ? 
ATOM   2977  C  CD    . LYS A 1 434 ? -24.836 24.589  -43.12   1    44.931  ? 434  LYS A CD    1 ? 
ATOM   2978  C  CE    . LYS A 1 434 ? -23.484 24.056  -42.947  1    46.493  ? 434  LYS A CE    1 ? 
ATOM   2979  N  NZ    . LYS A 1 434 ? -22.497 24.847  -43.682  1    41.034  ? 434  LYS A NZ    1 ? 
ATOM   2980  N  N     . ARG A 1 435 ? -28.449 26.865  -39.668  1    45.496  ? 435  ARG A N     1 ? 
ATOM   2981  C  CA    . ARG A 1 435 ? -28.787 27.873  -38.673  1    43.712  ? 435  ARG A CA    1 ? 
ATOM   2982  C  C     . ARG A 1 435 ? -29.8   27.321  -37.668  1    47.863  ? 435  ARG A C     1 ? 
ATOM   2983  O  O     . ARG A 1 435 ? -29.694 27.603  -36.47   1    44.85   ? 435  ARG A O     1 ? 
ATOM   2984  C  CB    . ARG A 1 435 ? -29.331 29.147  -39.327  1    46.909  ? 435  ARG A CB    1 ? 
ATOM   2985  C  CG    . ARG A 1 435 ? -29.661 30.336  -38.441  1    54.377  ? 435  ARG A CG    1 ? 
ATOM   2986  C  CD    . ARG A 1 435 ? -30.278 31.392  -39.351  1    63.987  ? 435  ARG A CD    1 ? 
ATOM   2987  N  NE    . ARG A 1 435 ? -30.763 32.555  -38.604  1    69.453  ? 435  ARG A NE    1 ? 
ATOM   2988  C  CZ    . ARG A 1 435 ? -32.032 32.766  -38.269  1    75.168  ? 435  ARG A CZ    1 ? 
ATOM   2989  N  NH1   . ARG A 1 435 ? -32.359 33.889  -37.657  1    65.487  ? 435  ARG A NH1   1 ? 
ATOM   2990  N  NH2   . ARG A 1 435 ? -32.965 31.864  -38.548  1    75.106  ? 435  ARG A NH2   1 ? 
ATOM   2991  N  N     . THR A 1 436 ? -30.786 26.553  -38.164  1    40.305  ? 436  THR A N     1 ? 
ATOM   2992  C  CA    . THR A 1 436 ? -31.828 26.009  -37.308  1    46.311  ? 436  THR A CA    1 ? 
ATOM   2993  C  C     . THR A 1 436 ? -31.199 25.065  -36.275  1    49.853  ? 436  THR A C     1 ? 
ATOM   2994  O  O     . THR A 1 436 ? -31.606 25.065  -35.108  1    47.945  ? 436  THR A O     1 ? 
ATOM   2995  C  CB    . THR A 1 436 ? -32.898 25.299  -38.142  1    45.221  ? 436  THR A CB    1 ? 
ATOM   2996  O  OG1   . THR A 1 436 ? -33.191 26.15   -39.245  1    51.63   ? 436  THR A OG1   1 ? 
ATOM   2997  C  CG2   . THR A 1 436 ? -34.14  24.939  -37.342  1    44.913  ? 436  THR A CG2   1 ? 
ATOM   2998  N  N     . TYR A 1 437 ? -30.237 24.243  -36.726  1    42.845  ? 437  TYR A N     1 ? 
ATOM   2999  C  CA    . TYR A 1 437 ? -29.617 23.245  -35.869  1    41.878  ? 437  TYR A CA    1 ? 
ATOM   3000  C  C     . TYR A 1 437 ? -28.873 23.963  -34.747  1    39.955  ? 437  TYR A C     1 ? 
ATOM   3001  O  O     . TYR A 1 437 ? -29.047 23.596  -33.579  1    37.918  ? 437  TYR A O     1 ? 
ATOM   3002  C  CB    . TYR A 1 437 ? -28.656 22.375  -36.682  1    40.353  ? 437  TYR A CB    1 ? 
ATOM   3003  C  CG    . TYR A 1 437 ? -27.577 21.581  -35.952  1    31.491  ? 437  TYR A CG    1 ? 
ATOM   3004  C  CD1   . TYR A 1 437 ? -27.829 20.288  -35.496  1    32.425  ? 437  TYR A CD1   1 ? 
ATOM   3005  C  CD2   . TYR A 1 437 ? -26.297 22.094  -35.772  1    30.309  ? 437  TYR A CD2   1 ? 
ATOM   3006  C  CE1   . TYR A 1 437 ? -26.833 19.51   -34.917  1    31.527  ? 437  TYR A CE1   1 ? 
ATOM   3007  C  CE2   . TYR A 1 437 ? -25.297 21.34   -35.162  1    29.807  ? 437  TYR A CE2   1 ? 
ATOM   3008  C  CZ    . TYR A 1 437 ? -25.573 20.052  -34.725  1    32.416  ? 437  TYR A CZ    1 ? 
ATOM   3009  O  OH    . TYR A 1 437 ? -24.613 19.26   -34.169  1    33.966  ? 437  TYR A OH    1 ? 
ATOM   3010  N  N     . TYR A 1 438 ? -28.112 25.007  -35.121  1    34.322  ? 438  TYR A N     1 ? 
ATOM   3011  C  CA    . TYR A 1 438 ? -27.275 25.724  -34.171  1    40.211  ? 438  TYR A CA    1 ? 
ATOM   3012  C  C     . TYR A 1 438 ? -28.135 26.398  -33.09   1    49.79   ? 438  TYR A C     1 ? 
ATOM   3013  O  O     . TYR A 1 438 ? -27.754 26.435  -31.915  1    45.887  ? 438  TYR A O     1 ? 
ATOM   3014  C  CB    . TYR A 1 438 ? -26.207 26.646  -34.772  1    39.27   ? 438  TYR A CB    1 ? 
ATOM   3015  C  CG    . TYR A 1 438 ? -25.056 25.991  -35.53   1    37.779  ? 438  TYR A CG    1 ? 
ATOM   3016  C  CD1   . TYR A 1 438 ? -23.998 25.359  -34.861  1    36.108  ? 438  TYR A CD1   1 ? 
ATOM   3017  C  CD2   . TYR A 1 438 ? -25.016 26.02   -36.921  1    34.63   ? 438  TYR A CD2   1 ? 
ATOM   3018  C  CE1   . TYR A 1 438 ? -22.957 24.746  -35.555  1    31.919  ? 438  TYR A CE1   1 ? 
ATOM   3019  C  CE2   . TYR A 1 438 ? -23.984 25.413  -37.631  1    34.429  ? 438  TYR A CE2   1 ? 
ATOM   3020  C  CZ    . TYR A 1 438 ? -22.951 24.776  -36.95   1    33.023  ? 438  TYR A CZ    1 ? 
ATOM   3021  O  OH    . TYR A 1 438 ? -21.927 24.215  -37.669  1    28.105  ? 438  TYR A OH    1 ? 
ATOM   3022  N  N     . MET A 1 439 ? -29.294 26.935  -33.492  1    46.057  ? 439  MET A N     1 ? 
ATOM   3023  C  CA    . MET A 1 439 ? -30.175 27.623  -32.565  1    45.98   ? 439  MET A CA    1 ? 
ATOM   3024  C  C     . MET A 1 439 ? -30.92  26.602  -31.705  1    40.487  ? 439  MET A C     1 ? 
ATOM   3025  O  O     . MET A 1 439 ? -31.1   26.817  -30.519  1    44.609  ? 439  MET A O     1 ? 
ATOM   3026  C  CB    . MET A 1 439 ? -31.178 28.516  -33.311  1    43.672  ? 439  MET A CB    1 ? 
ATOM   3027  C  CG    . MET A 1 439 ? -30.534 29.689  -34.041  1    51.934  ? 439  MET A CG    1 ? 
ATOM   3028  S  SD    . MET A 1 439 ? -31.723 30.858  -34.754  1    55.168  ? 439  MET A SD    1 ? 
ATOM   3029  C  CE    . MET A 1 439 ? -32.87  29.764  -35.613  1    56.16   ? 439  MET A CE    1 ? 
ATOM   3030  N  N     . THR A 1 440 ? -31.366 25.508  -32.319  1    46.953  ? 440  THR A N     1 ? 
ATOM   3031  C  CA    . THR A 1 440 ? -32.242 24.542  -31.676  1    54.622  ? 440  THR A CA    1 ? 
ATOM   3032  C  C     . THR A 1 440 ? -31.454 23.595  -30.773  1    60.482  ? 440  THR A C     1 ? 
ATOM   3033  O  O     . THR A 1 440 ? -32.004 23.104  -29.796  1    61.799  ? 440  THR A O     1 ? 
ATOM   3034  C  CB    . THR A 1 440 ? -33.017 23.771  -32.744  1    60.441  ? 440  THR A CB    1 ? 
ATOM   3035  O  OG1   . THR A 1 440 ? -33.833 24.788  -33.313  1    79.883  ? 440  THR A OG1   1 ? 
ATOM   3036  C  CG2   . THR A 1 440 ? -33.917 22.671  -32.204  1    61.311  ? 440  THR A CG2   1 ? 
ATOM   3037  N  N     . LYS A 1 441 ? -30.192 23.306  -31.112  1    58.137  ? 441  LYS A N     1 ? 
ATOM   3038  C  CA    . LYS A 1 441 ? -29.479 22.244  -30.42   1    56.274  ? 441  LYS A CA    1 ? 
ATOM   3039  C  C     . LYS A 1 441 ? -28.46  22.84   -29.453  1    55.34   ? 441  LYS A C     1 ? 
ATOM   3040  O  O     . LYS A 1 441 ? -28.152 22.234  -28.438  1    65.892  ? 441  LYS A O     1 ? 
ATOM   3041  C  CB    . LYS A 1 441 ? -28.832 21.237  -31.38   1    51.501  ? 441  LYS A CB    1 ? 
ATOM   3042  C  CG    . LYS A 1 441 ? -29.759 20.379  -32.223  1    47.506  ? 441  LYS A CG    1 ? 
ATOM   3043  C  CD    . LYS A 1 441 ? -30.703 19.496  -31.424  1    57.321  ? 441  LYS A CD    1 ? 
ATOM   3044  C  CE    . LYS A 1 441 ? -31.177 18.306  -32.187  1    54.042  ? 441  LYS A CE    1 ? 
ATOM   3045  N  NZ    . LYS A 1 441 ? -32.264 17.645  -31.454  1    56.84   ? 441  LYS A NZ    1 ? 
ATOM   3046  N  N     . MET A 1 442 ? -27.927 24.016  -29.78   1    51.67   ? 442  MET A N     1 ? 
ATOM   3047  C  CA    . MET A 1 442 ? -26.918 24.656  -28.952  1    46.611  ? 442  MET A CA    1 ? 
ATOM   3048  C  C     . MET A 1 442 ? -27.494 25.921  -28.318  1    55.763  ? 442  MET A C     1 ? 
ATOM   3049  O  O     . MET A 1 442 ? -26.773 26.666  -27.64   1    53.571  ? 442  MET A O     1 ? 
ATOM   3050  C  CB    . MET A 1 442 ? -25.703 25.06   -29.793  1    42.822  ? 442  MET A CB    1 ? 
ATOM   3051  C  CG    . MET A 1 442 ? -25.219 23.938  -30.694  1    40.377  ? 442  MET A CG    1 ? 
ATOM   3052  S  SD    . MET A 1 442 ? -23.492 24.269  -31.055  1    45.667  ? 442  MET A SD    1 ? 
ATOM   3053  C  CE    . MET A 1 442 ? -23.28  22.97   -32.293  1    35.017  ? 442  MET A CE    1 ? 
ATOM   3054  N  N     . GLY A 1 443 ? -28.792 26.162  -28.568  1    60.761  ? 443  GLY A N     1 ? 
ATOM   3055  C  CA    . GLY A 1 443 ? -29.499 27.328  -28.052  1    61.148  ? 443  GLY A CA    1 ? 
ATOM   3056  C  C     . GLY A 1 443 ? -28.701 28.627  -28.207  1    65.131  ? 443  GLY A C     1 ? 
ATOM   3057  O  O     . GLY A 1 443 ? -28.697 29.477  -27.319  1    63.957  ? 443  GLY A O     1 ? 
ATOM   3058  N  N     . VAL A 1 444 ? -28.023 28.789  -29.346  1    60.653  ? 444  VAL A N     1 ? 
ATOM   3059  C  CA    . VAL A 1 444 ? -27.33  30.04   -29.596  1    60.178  ? 444  VAL A CA    1 ? 
ATOM   3060  C  C     . VAL A 1 444 ? -28.325 30.986  -30.261  1    58.036  ? 444  VAL A C     1 ? 
ATOM   3061  O  O     . VAL A 1 444 ? -29.302 30.546  -30.865  1    54.069  ? 444  VAL A O     1 ? 
ATOM   3062  C  CB    . VAL A 1 444 ? -26.012 29.913  -30.387  1    61.178  ? 444  VAL A CB    1 ? 
ATOM   3063  C  CG1   . VAL A 1 444 ? -26.254 29.367  -31.785  1    64.052  ? 444  VAL A CG1   1 ? 
ATOM   3064  C  CG2   . VAL A 1 444 ? -25.242 31.229  -30.444  1    57      ? 444  VAL A CG2   1 ? 
ATOM   3065  N  N     . ASP A 1 445 ? -28.044 32.284  -30.122  1    62.822  ? 445  ASP A N     1 ? 
ATOM   3066  C  CA    . ASP A 1 445 ? -28.963 33.353  -30.461  1    68.252  ? 445  ASP A CA    1 ? 
ATOM   3067  C  C     . ASP A 1 445 ? -28.717 33.81   -31.905  1    63.618  ? 445  ASP A C     1 ? 
ATOM   3068  O  O     . ASP A 1 445 ? -29.646 33.827  -32.701  1    58.725  ? 445  ASP A O     1 ? 
ATOM   3069  C  CB    . ASP A 1 445 ? -28.955 34.385  -29.342  1    78.753  ? 445  ASP A CB    1 ? 
ATOM   3070  C  CG    . ASP A 1 445 ? -29.879 35.575  -29.536  1    97.618  ? 445  ASP A CG    1 ? 
ATOM   3071  O  OD1   . ASP A 1 445 ? -30.968 35.372  -30.118  1    105.457 ? 445  ASP A OD1   1 ? 
ATOM   3072  O  OD2   . ASP A 1 445 ? -29.51  36.684  -29.078  1    99.163  ? 445  ASP A OD2   1 ? 
ATOM   3073  N  N     . VAL A 1 446 ? -27.453 34.094  -32.249  1    58.01   ? 446  VAL A N     1 ? 
ATOM   3074  C  CA    . VAL A 1 446 ? -27.065 34.688  -33.518  1    53.518  ? 446  VAL A CA    1 ? 
ATOM   3075  C  C     . VAL A 1 446 ? -26.044 33.805  -34.252  1    51.532  ? 446  VAL A C     1 ? 
ATOM   3076  O  O     . VAL A 1 446 ? -24.841 33.862  -33.991  1    44.799  ? 446  VAL A O     1 ? 
ATOM   3077  C  CB    . VAL A 1 446 ? -26.49  36.078  -33.182  1    57.797  ? 446  VAL A CB    1 ? 
ATOM   3078  C  CG1   . VAL A 1 446 ? -25.409 36.009  -32.102  1    74.749  ? 446  VAL A CG1   1 ? 
ATOM   3079  C  CG2   . VAL A 1 446 ? -25.964 36.803  -34.412  1    58.806  ? 446  VAL A CG2   1 ? 
ATOM   3080  N  N     . VAL A 1 447 ? -26.512 33.038  -35.243  1    48.083  ? 447  VAL A N     1 ? 
ATOM   3081  C  CA    . VAL A 1 447 ? -25.631 32.098  -35.929  1    47.037  ? 447  VAL A CA    1 ? 
ATOM   3082  C  C     . VAL A 1 447 ? -24.873 32.822  -37.04   1    45.485  ? 447  VAL A C     1 ? 
ATOM   3083  O  O     . VAL A 1 447 ? -25.204 32.705  -38.221  1    46.346  ? 447  VAL A O     1 ? 
ATOM   3084  C  CB    . VAL A 1 447 ? -26.39  30.848  -36.415  1    42.751  ? 447  VAL A CB    1 ? 
ATOM   3085  C  CG1   . VAL A 1 447 ? -25.478 29.804  -37.039  1    45.876  ? 447  VAL A CG1   1 ? 
ATOM   3086  C  CG2   . VAL A 1 447 ? -27.233 30.236  -35.295  1    43.319  ? 447  VAL A CG2   1 ? 
ATOM   3087  N  N     . SER A 1 448 ? -23.816 33.533  -36.634  1    41.751  ? 448  SER A N     1 ? 
ATOM   3088  C  CA    . SER A 1 448 ? -23.013 34.354  -37.522  1    41.079  ? 448  SER A CA    1 ? 
ATOM   3089  C  C     . SER A 1 448 ? -21.74  33.642  -37.966  1    47.783  ? 448  SER A C     1 ? 
ATOM   3090  O  O     . SER A 1 448 ? -21.325 32.644  -37.373  1    44.005  ? 448  SER A O     1 ? 
ATOM   3091  C  CB    . SER A 1 448 ? -22.618 35.599  -36.823  1    40.098  ? 448  SER A CB    1 ? 
ATOM   3092  O  OG    . SER A 1 448 ? -21.947 35.251  -35.63   1    47.218  ? 448  SER A OG    1 ? 
ATOM   3093  N  N     . ASP A 1 449 ? -21.082 34.23   -38.974  1    38.782  ? 449  ASP A N     1 ? 
ATOM   3094  C  CA    . ASP A 1 449 ? -19.83  33.688  -39.47   1    47.291  ? 449  ASP A CA    1 ? 
ATOM   3095  C  C     . ASP A 1 449 ? -18.786 33.657  -38.357  1    43.289  ? 449  ASP A C     1 ? 
ATOM   3096  O  O     . ASP A 1 449 ? -17.901 32.801  -38.354  1    42.844  ? 449  ASP A O     1 ? 
ATOM   3097  C  CB    . ASP A 1 449 ? -19.354 34.353  -40.751  1    44.831  ? 449  ASP A CB    1 ? 
ATOM   3098  C  CG    . ASP A 1 449 ? -20.145 33.986  -42.005  1    52.164  ? 449  ASP A CG    1 ? 
ATOM   3099  O  OD1   . ASP A 1 449 ? -21.165 33.25   -41.885  1    45.579  ? 449  ASP A OD1   1 ? 
ATOM   3100  O  OD2   . ASP A 1 449 ? -19.728 34.443  -43.098  1    55.753  ? 449  ASP A OD2   1 ? 
ATOM   3101  N  N     . ASP A 1 450 ? -18.878 34.61   -37.436  1    40.495  ? 450  ASP A N     1 ? 
ATOM   3102  C  CA    . ASP A 1 450 ? -17.893 34.675  -36.375  1    40.082  ? 450  ASP A CA    1 ? 
ATOM   3103  C  C     . ASP A 1 450 ? -18.146 33.543  -35.373  1    36.081  ? 450  ASP A C     1 ? 
ATOM   3104  O  O     . ASP A 1 450 ? -17.216 32.876  -34.935  1    41.068  ? 450  ASP A O     1 ? 
ATOM   3105  C  CB    . ASP A 1 450 ? -17.857 36.065  -35.774  1    53.962  ? 450  ASP A CB    1 ? 
ATOM   3106  C  CG    . ASP A 1 450 ? -16.57  36.368  -35.032  1    58.895  ? 450  ASP A CG    1 ? 
ATOM   3107  O  OD1   . ASP A 1 450 ? -15.528 36.514  -35.704  1    72.008  ? 450  ASP A OD1   1 ? 
ATOM   3108  O  OD2   . ASP A 1 450 ? -16.626 36.418  -33.801  1    61.462  ? 450  ASP A OD2   1 ? 
ATOM   3109  N  N     . PHE A 1 451 ? -19.417 33.312  -35.04   1    31.941  ? 451  PHE A N     1 ? 
ATOM   3110  C  CA    . PHE A 1 451 ? -19.805 32.179  -34.225  1    34.504  ? 451  PHE A CA    1 ? 
ATOM   3111  C  C     . PHE A 1 451 ? -19.364 30.863  -34.879  1    42.376  ? 451  PHE A C     1 ? 
ATOM   3112  O  O     . PHE A 1 451 ? -18.895 29.957  -34.182  1    36.352  ? 451  PHE A O     1 ? 
ATOM   3113  C  CB    . PHE A 1 451 ? -21.307 32.285  -33.974  1    32.285  ? 451  PHE A CB    1 ? 
ATOM   3114  C  CG    . PHE A 1 451 ? -21.871 30.944  -33.549  1    34.346  ? 451  PHE A CG    1 ? 
ATOM   3115  C  CD1   . PHE A 1 451 ? -21.817 30.533  -32.218  1    34.866  ? 451  PHE A CD1   1 ? 
ATOM   3116  C  CD2   . PHE A 1 451 ? -22.37  30.054  -34.496  1    33.636  ? 451  PHE A CD2   1 ? 
ATOM   3117  C  CE1   . PHE A 1 451 ? -22.323 29.293  -31.85   1    33.069  ? 451  PHE A CE1   1 ? 
ATOM   3118  C  CE2   . PHE A 1 451 ? -22.858 28.811  -34.127  1    34.011  ? 451  PHE A CE2   1 ? 
ATOM   3119  C  CZ    . PHE A 1 451 ? -22.842 28.438  -32.798  1    36.403  ? 451  PHE A CZ    1 ? 
ATOM   3120  N  N     . LEU A 1 452 ? -19.504 30.773  -36.217  1    37.312  ? 452  LEU A N     1 ? 
ATOM   3121  C  CA    . LEU A 1 452 ? -19.128 29.58   -36.961  1    34.889  ? 452  LEU A CA    1 ? 
ATOM   3122  C  C     . LEU A 1 452 ? -17.62  29.383  -36.909  1    31.705  ? 452  LEU A C     1 ? 
ATOM   3123  O  O     . LEU A 1 452 ? -17.168 28.24   -36.87   1    31.829  ? 452  LEU A O     1 ? 
ATOM   3124  C  CB    . LEU A 1 452 ? -19.644 29.462  -38.401  1    35.996  ? 452  LEU A CB    1 ? 
ATOM   3125  C  CG    . LEU A 1 452 ? -21.164 29.34   -38.549  1    35.651  ? 452  LEU A CG    1 ? 
ATOM   3126  C  CD1   . LEU A 1 452 ? -21.62  29.456  -40.007  1    38.316  ? 452  LEU A CD1   1 ? 
ATOM   3127  C  CD2   . LEU A 1 452 ? -21.751 28.094  -37.917  1    33.12   ? 452  LEU A CD2   1 ? 
ATOM   3128  N  N     . ALA A 1 453 ? -16.85  30.479  -36.944  1    33.045  ? 453  ALA A N     1 ? 
ATOM   3129  C  CA    . ALA A 1 453 ? -15.397 30.347  -36.89   1    34.709  ? 453  ALA A CA    1 ? 
ATOM   3130  C  C     . ALA A 1 453 ? -14.994 29.888  -35.484  1    36.442  ? 453  ALA A C     1 ? 
ATOM   3131  O  O     . ALA A 1 453 ? -14.025 29.154  -35.301  1    34.546  ? 453  ALA A O     1 ? 
ATOM   3132  C  CB    . ALA A 1 453 ? -14.728 31.653  -37.227  1    31.015  ? 453  ALA A CB    1 ? 
ATOM   3133  N  N     . ASP A 1 454 ? -15.753 30.352  -34.496  1    34.858  ? 454  ASP A N     1 ? 
ATOM   3134  C  CA    . ASP A 1 454 ? -15.555 29.945  -33.12   1    35.973  ? 454  ASP A CA    1 ? 
ATOM   3135  C  C     . ASP A 1 454 ? -15.867 28.454  -32.96   1    31.139  ? 454  ASP A C     1 ? 
ATOM   3136  O  O     . ASP A 1 454 ? -15.092 27.742  -32.344  1    33.405  ? 454  ASP A O     1 ? 
ATOM   3137  C  CB    . ASP A 1 454 ? -16.249 30.935  -32.204  1    44.854  ? 454  ASP A CB    1 ? 
ATOM   3138  C  CG    . ASP A 1 454 ? -15.623 31.057  -30.826  1    69.023  ? 454  ASP A CG    1 ? 
ATOM   3139  O  OD1   . ASP A 1 454 ? -15.627 30.041  -30.098  1    66.926  ? 454  ASP A OD1   1 ? 
ATOM   3140  O  OD2   . ASP A 1 454 ? -15.119 32.163  -30.515  1    88.437  ? 454  ASP A OD2   1 ? 
ATOM   3141  N  N     . GLN A 1 455 ? -16.965 27.97   -33.55   1    26.56   ? 455  GLN A N     1 ? 
ATOM   3142  C  CA    . GLN A 1 455 ? -17.258 26.549  -33.552  1    29.59   ? 455  GLN A CA    1 ? 
ATOM   3143  C  C     . GLN A 1 455 ? -16.079 25.765  -34.134  1    34.909  ? 455  GLN A C     1 ? 
ATOM   3144  O  O     . GLN A 1 455 ? -15.683 24.727  -33.589  1    32.078  ? 455  GLN A O     1 ? 
ATOM   3145  C  CB    . GLN A 1 455 ? -18.457 26.242  -34.445  1    33.276  ? 455  GLN A CB    1 ? 
ATOM   3146  C  CG    . GLN A 1 455 ? -19.816 26.6    -33.846  1    33.289  ? 455  GLN A CG    1 ? 
ATOM   3147  C  CD    . GLN A 1 455 ? -20.194 25.754  -32.653  1    32.084  ? 455  GLN A CD    1 ? 
ATOM   3148  O  OE1   . GLN A 1 455 ? -20.688 24.635  -32.796  1    34.219  ? 455  GLN A OE1   1 ? 
ATOM   3149  N  NE2   . GLN A 1 455 ? -20.057 26.321  -31.464  1    30.837  ? 455  GLN A NE2   1 ? 
ATOM   3150  N  N     . ALA A 1 456 ? -15.543 26.243  -35.269  1    31.328  ? 456  ALA A N     1 ? 
ATOM   3151  C  CA    . ALA A 1 456 ? -14.492 25.524  -35.972  1    32.456  ? 456  ALA A CA    1 ? 
ATOM   3152  C  C     . ALA A 1 456 ? -13.268 25.421  -35.059  1    33.009  ? 456  ALA A C     1 ? 
ATOM   3153  O  O     . ALA A 1 456 ? -12.669 24.351  -34.952  1    30.992  ? 456  ALA A O     1 ? 
ATOM   3154  C  CB    . ALA A 1 456 ? -14.151 26.218  -37.277  1    31.399  ? 456  ALA A CB    1 ? 
ATOM   3155  N  N     . ALA A 1 457 ? -12.944 26.538  -34.39   1    30.471  ? 457  ALA A N     1 ? 
ATOM   3156  C  CA    . ALA A 1 457 ? -11.822 26.621  -33.468  1    31.449  ? 457  ALA A CA    1 ? 
ATOM   3157  C  C     . ALA A 1 457 ? -11.993 25.656  -32.287  1    28.351  ? 457  ALA A C     1 ? 
ATOM   3158  O  O     . ALA A 1 457 ? -11.028 25.02   -31.903  1    26.999  ? 457  ALA A O     1 ? 
ATOM   3159  C  CB    . ALA A 1 457 ? -11.613 28.055  -32.997  1    30.12   ? 457  ALA A CB    1 ? 
ATOM   3160  N  N     . CYS A 1 458 ? -13.197 25.553  -31.704  1    32.222  ? 458  CYS A N     1 ? 
ATOM   3161  C  CA    . CYS A 1 458 ? -13.409 24.677  -30.557  1    30.494  ? 458  CYS A CA    1 ? 
ATOM   3162  C  C     . CYS A 1 458 ? -13.179 23.24   -30.99   1    30.156  ? 458  CYS A C     1 ? 
ATOM   3163  O  O     . CYS A 1 458 ? -12.564 22.461  -30.268  1    26.791  ? 458  CYS A O     1 ? 
ATOM   3164  C  CB    . CYS A 1 458 ? -14.837 24.711  -30.015  1    34.654  ? 458  CYS A CB    1 ? 
ATOM   3165  S  SG    . CYS A 1 458 ? -15.196 26.208  -29.057  1    48.394  ? 458  CYS A SG    1 ? 
ATOM   3166  N  N     . TYR A 1 459 ? -13.675 22.92   -32.186  1    26.362  ? 459  TYR A N     1 ? 
ATOM   3167  C  CA    . TYR A 1 459 ? -13.642 21.555  -32.667  1    26.052  ? 459  TYR A CA    1 ? 
ATOM   3168  C  C     . TYR A 1 459 ? -12.195 21.094  -32.857  1    28      ? 459  TYR A C     1 ? 
ATOM   3169  O  O     . TYR A 1 459 ? -11.825 19.979  -32.476  1    27.254  ? 459  TYR A O     1 ? 
ATOM   3170  C  CB    . TYR A 1 459 ? -14.52  21.367  -33.907  1    28.26   ? 459  TYR A CB    1 ? 
ATOM   3171  C  CG    . TYR A 1 459 ? -14.602 19.898  -34.263  1    28.8    ? 459  TYR A CG    1 ? 
ATOM   3172  C  CD1   . TYR A 1 459 ? -15.524 19.061  -33.646  1    26.811  ? 459  TYR A CD1   1 ? 
ATOM   3173  C  CD2   . TYR A 1 459 ? -13.731 19.348  -35.192  1    28.441  ? 459  TYR A CD2   1 ? 
ATOM   3174  C  CE1   . TYR A 1 459 ? -15.585 17.712  -33.957  1    29.501  ? 459  TYR A CE1   1 ? 
ATOM   3175  C  CE2   . TYR A 1 459 ? -13.789 17.998  -35.512  1    28.188  ? 459  TYR A CE2   1 ? 
ATOM   3176  C  CZ    . TYR A 1 459 ? -14.684 17.175  -34.859  1    29.299  ? 459  TYR A CZ    1 ? 
ATOM   3177  O  OH    . TYR A 1 459 ? -14.749 15.841  -35.174  1    32.448  ? 459  TYR A OH    1 ? 
ATOM   3178  N  N     . VAL A 1 460 ? -11.392 21.945  -33.496  1    30.166  ? 460  VAL A N     1 ? 
ATOM   3179  C  CA    . VAL A 1 460 ? -10.04  21.559  -33.855  1    30.605  ? 460  VAL A CA    1 ? 
ATOM   3180  C  C     . VAL A 1 460 ? -9.186  21.536  -32.587  1    28.176  ? 460  VAL A C     1 ? 
ATOM   3181  O  O     . VAL A 1 460 ? -8.29   20.721  -32.436  1    26.663  ? 460  VAL A O     1 ? 
ATOM   3182  C  CB    . VAL A 1 460 ? -9.445  22.459  -34.968  1    35.16   ? 460  VAL A CB    1 ? 
ATOM   3183  C  CG1   . VAL A 1 460 ? -7.932  22.327  -35.041  1    37.821  ? 460  VAL A CG1   1 ? 
ATOM   3184  C  CG2   . VAL A 1 460 ? -10.049 22.167  -36.348  1    33.295  ? 460  VAL A CG2   1 ? 
ATOM   3185  N  N     . GLN A 1 461 ? -9.465  22.424  -31.647  1    29.819  ? 461  GLN A N     1 ? 
ATOM   3186  C  CA    . GLN A 1 461 ? -8.758  22.338  -30.373  1    27.084  ? 461  GLN A CA    1 ? 
ATOM   3187  C  C     . GLN A 1 461 ? -9.122  21.039  -29.634  1    23.756  ? 461  GLN A C     1 ? 
ATOM   3188  O  O     . GLN A 1 461 ? -8.279  20.419  -29.015  1    26.684  ? 461  GLN A O     1 ? 
ATOM   3189  C  CB    . GLN A 1 461 ? -9.037  23.594  -29.556  1    30.996  ? 461  GLN A CB    1 ? 
ATOM   3190  C  CG    . GLN A 1 461 ? -8.331  23.572  -28.21   1    42.164  ? 461  GLN A CG    1 ? 
ATOM   3191  C  CD    . GLN A 1 461 ? -8.48   24.844  -27.406  1    54.386  ? 461  GLN A CD    1 ? 
ATOM   3192  O  OE1   . GLN A 1 461 ? -9.551  25.463  -27.368  1    59.945  ? 461  GLN A OE1   1 ? 
ATOM   3193  N  NE2   . GLN A 1 461 ? -7.398  25.233  -26.746  1    45.55   ? 461  GLN A NE2   1 ? 
ATOM   3194  N  N     . ALA A 1 462 ? -10.377 20.595  -29.722  1    22.492  ? 462  ALA A N     1 ? 
ATOM   3195  C  CA    . ALA A 1 462 ? -10.757 19.323  -29.138  1    23.971  ? 462  ALA A CA    1 ? 
ATOM   3196  C  C     . ALA A 1 462 ? -9.952  18.175  -29.771  1    24.361  ? 462  ALA A C     1 ? 
ATOM   3197  O  O     . ALA A 1 462 ? -9.496  17.265  -29.09   1    25.577  ? 462  ALA A O     1 ? 
ATOM   3198  C  CB    . ALA A 1 462 ? -12.246 19.156  -29.313  1    20.539  ? 462  ALA A CB    1 ? 
ATOM   3199  N  N     . ILE A 1 463 ? -9.806  18.188  -31.106  1    24.825  ? 463  ILE A N     1 ? 
ATOM   3200  C  CA    . ILE A 1 463 ? -9.143  17.093  -31.796  1    27.488  ? 463  ILE A CA    1 ? 
ATOM   3201  C  C     . ILE A 1 463 ? -7.694  17.054  -31.32   1    24.409  ? 463  ILE A C     1 ? 
ATOM   3202  O  O     . ILE A 1 463 ? -7.205  16.009  -30.91   1    25.447  ? 463  ILE A O     1 ? 
ATOM   3203  C  CB    . ILE A 1 463 ? -9.221  17.204  -33.343  1    26.703  ? 463  ILE A CB    1 ? 
ATOM   3204  C  CG1   . ILE A 1 463 ? -10.668 17.083  -33.879  1    23.857  ? 463  ILE A CG1   1 ? 
ATOM   3205  C  CG2   . ILE A 1 463 ? -8.29   16.154  -33.968  1    26.865  ? 463  ILE A CG2   1 ? 
ATOM   3206  C  CD1   . ILE A 1 463 ? -11.323 15.702  -33.765  1    22.265  ? 463  ILE A CD1   1 ? 
ATOM   3207  N  N     . GLN A 1 464 ? -7.085  18.227  -31.215  1    24.129  ? 464  GLN A N     1 ? 
ATOM   3208  C  CA    . GLN A 1 464 ? -5.722  18.31   -30.699  1    27.737  ? 464  GLN A CA    1 ? 
ATOM   3209  C  C     . GLN A 1 464 ? -5.624  17.901  -29.212  1    26.43   ? 464  GLN A C     1 ? 
ATOM   3210  O  O     . GLN A 1 464 ? -4.635  17.3    -28.816  1    24.318  ? 464  GLN A O     1 ? 
ATOM   3211  C  CB    . GLN A 1 464 ? -5.122  19.708  -30.877  1    24.416  ? 464  GLN A CB    1 ? 
ATOM   3212  C  CG    . GLN A 1 464 ? -3.691  19.812  -30.337  1    26.437  ? 464  GLN A CG    1 ? 
ATOM   3213  C  CD    . GLN A 1 464 ? -2.728  18.917  -31.076  1    30.226  ? 464  GLN A CD    1 ? 
ATOM   3214  O  OE1   . GLN A 1 464 ? -2.294  19.244  -32.179  1    36.852  ? 464  GLN A OE1   1 ? 
ATOM   3215  N  NE2   . GLN A 1 464 ? -2.434  17.75   -30.527  1    28.824  ? 464  GLN A NE2   1 ? 
ATOM   3216  N  N     . TRP A 1 465 ? -6.624  18.227  -28.371  1    26.384  ? 465  TRP A N     1 ? 
ATOM   3217  C  CA    . TRP A 1 465 ? -6.596  17.783  -26.97   1    22.834  ? 465  TRP A CA    1 ? 
ATOM   3218  C  C     . TRP A 1 465 ? -6.556  16.246  -26.919  1    23.978  ? 465  TRP A C     1 ? 
ATOM   3219  O  O     . TRP A 1 465 ? -5.742  15.666  -26.195  1    27.674  ? 465  TRP A O     1 ? 
ATOM   3220  C  CB    . TRP A 1 465 ? -7.786  18.35   -26.157  1    20.06   ? 465  TRP A CB    1 ? 
ATOM   3221  C  CG    . TRP A 1 465 ? -7.735  17.946  -24.704  1    19.488  ? 465  TRP A CG    1 ? 
ATOM   3222  C  CD1   . TRP A 1 465 ? -7.214  18.66   -23.671  1    20.019  ? 465  TRP A CD1   1 ? 
ATOM   3223  C  CD2   . TRP A 1 465 ? -8.141  16.681  -24.143  1    17.737  ? 465  TRP A CD2   1 ? 
ATOM   3224  N  NE1   . TRP A 1 465 ? -7.23   17.927  -22.514  1    18.665  ? 465  TRP A NE1   1 ? 
ATOM   3225  C  CE2   . TRP A 1 465 ? -7.836  16.726  -22.766  1    19.362  ? 465  TRP A CE2   1 ? 
ATOM   3226  C  CE3   . TRP A 1 465 ? -8.801  15.558  -24.648  1    18.379  ? 465  TRP A CE3   1 ? 
ATOM   3227  C  CZ2   . TRP A 1 465 ? -8.112  15.664  -21.902  1    19.143  ? 465  TRP A CZ2   1 ? 
ATOM   3228  C  CZ3   . TRP A 1 465 ? -9.097  14.515  -23.795  1    19.266  ? 465  TRP A CZ3   1 ? 
ATOM   3229  C  CH2   . TRP A 1 465 ? -8.745  14.573  -22.441  1    18.294  ? 465  TRP A CH2   1 ? 
ATOM   3230  N  N     . ILE A 1 466 ? -7.431  15.584  -27.706  1    24.304  ? 466  ILE A N     1 ? 
ATOM   3231  C  CA    . ILE A 1 466 ? -7.544  14.131  -27.732  1    23.123  ? 466  ILE A CA    1 ? 
ATOM   3232  C  C     . ILE A 1 466 ? -6.23   13.502  -28.188  1    23.854  ? 466  ILE A C     1 ? 
ATOM   3233  O  O     . ILE A 1 466 ? -5.844  12.444  -27.677  1    22.64   ? 466  ILE A O     1 ? 
ATOM   3234  C  CB    . ILE A 1 466 ? -8.712  13.647  -28.62   1    29.695  ? 466  ILE A CB    1 ? 
ATOM   3235  C  CG1   . ILE A 1 466 ? -10.04  14.161  -28.144  1    39.965  ? 466  ILE A CG1   1 ? 
ATOM   3236  C  CG2   . ILE A 1 466 ? -8.761  12.126  -28.707  1    30.824  ? 466  ILE A CG2   1 ? 
ATOM   3237  C  CD1   . ILE A 1 466 ? -11.216 13.474  -28.813  1    44.074  ? 466  ILE A CD1   1 ? 
ATOM   3238  N  N     . LEU A 1 467 ? -5.605  14.084  -29.225  1    25.204  ? 467  LEU A N     1 ? 
ATOM   3239  C  CA    . LEU A 1 467 ? -4.379  13.499  -29.743  1    26.005  ? 467  LEU A CA    1 ? 
ATOM   3240  C  C     . LEU A 1 467 ? -3.297  13.606  -28.661  1    23.766  ? 467  LEU A C     1 ? 
ATOM   3241  O  O     . LEU A 1 467 ? -2.554  12.659  -28.42   1    24.676  ? 467  LEU A O     1 ? 
ATOM   3242  C  CB    . LEU A 1 467 ? -3.991  14.222  -31.033  1    25.618  ? 467  LEU A CB    1 ? 
ATOM   3243  C  CG    . LEU A 1 467 ? -4.81   13.882  -32.284  1    26.048  ? 467  LEU A CG    1 ? 
ATOM   3244  C  CD1   . LEU A 1 467 ? -4.578  14.966  -33.323  1    27.76   ? 467  LEU A CD1   1 ? 
ATOM   3245  C  CD2   . LEU A 1 467 ? -4.341  12.548  -32.853  1    22.942  ? 467  LEU A CD2   1 ? 
ATOM   3246  N  N     . HIS A 1 468 ? -3.161  14.784  -28.043  1    23.973  ? 468  HIS A N     1 ? 
ATOM   3247  C  CA    . HIS A 1 468 ? -2.227  14.899  -26.931  1    23.342  ? 468  HIS A CA    1 ? 
ATOM   3248  C  C     . HIS A 1 468 ? -2.523  13.787  -25.932  1    24.693  ? 468  HIS A C     1 ? 
ATOM   3249  O  O     . HIS A 1 468 ? -1.635  13.061  -25.492  1    25.683  ? 468  HIS A O     1 ? 
ATOM   3250  C  CB    . HIS A 1 468 ? -2.304  16.294  -26.306  1    29.935  ? 468  HIS A CB    1 ? 
ATOM   3251  C  CG    . HIS A 1 468 ? -1.516  17.351  -27.018  1    32.412  ? 468  HIS A CG    1 ? 
ATOM   3252  N  ND1   . HIS A 1 468 ? -0.293  17.091  -27.607  1    32.114  ? 468  HIS A ND1   1 ? 
ATOM   3253  C  CD2   . HIS A 1 468 ? -1.769  18.659  -27.238  1    33.805  ? 468  HIS A CD2   1 ? 
ATOM   3254  C  CE1   . HIS A 1 468 ? 0.184   18.222  -28.143  1    34.28   ? 468  HIS A CE1   1 ? 
ATOM   3255  N  NE2   . HIS A 1 468 ? -0.689  19.191  -27.928  1    34.034  ? 468  HIS A NE2   1 ? 
ATOM   3256  N  N     . TYR A 1 469 ? -3.812  13.597  -25.621  1    22.649  ? 469  TYR A N     1 ? 
ATOM   3257  C  CA    . TYR A 1 469 ? -4.158  12.699  -24.523  1    21.592  ? 469  TYR A CA    1 ? 
ATOM   3258  C  C     . TYR A 1 469 ? -3.658  11.287  -24.837  1    19.411  ? 469  TYR A C     1 ? 
ATOM   3259  O  O     . TYR A 1 469 ? -3.095  10.617  -23.97   1    21.025  ? 469  TYR A O     1 ? 
ATOM   3260  C  CB    . TYR A 1 469 ? -5.691  12.721  -24.377  1    21.519  ? 469  TYR A CB    1 ? 
ATOM   3261  C  CG    . TYR A 1 469 ? -6.296  11.99   -23.19   1    24.344  ? 469  TYR A CG    1 ? 
ATOM   3262  C  CD1   . TYR A 1 469 ? -5.744  12.055  -21.924  1    25.274  ? 469  TYR A CD1   1 ? 
ATOM   3263  C  CD2   . TYR A 1 469 ? -7.477  11.294  -23.332  1    30.49   ? 469  TYR A CD2   1 ? 
ATOM   3264  C  CE1   . TYR A 1 469 ? -6.325  11.428  -20.836  1    25.696  ? 469  TYR A CE1   1 ? 
ATOM   3265  C  CE2   . TYR A 1 469 ? -8.073  10.657  -22.259  1    32.166  ? 469  TYR A CE2   1 ? 
ATOM   3266  C  CZ    . TYR A 1 469 ? -7.498  10.73   -21.008  1    29.341  ? 469  TYR A CZ    1 ? 
ATOM   3267  O  OH    . TYR A 1 469 ? -8.132  10.087  -19.99   1    32.9    ? 469  TYR A OH    1 ? 
ATOM   3268  N  N     . TYR A 1 470 ? -3.857  10.836  -26.074  1    21.805  ? 470  TYR A N     1 ? 
ATOM   3269  C  CA    . TYR A 1 470 ? -3.506  9.47    -26.477  1    25.591  ? 470  TYR A CA    1 ? 
ATOM   3270  C  C     . TYR A 1 470 ? -1.994  9.282   -26.664  1    27.02   ? 470  TYR A C     1 ? 
ATOM   3271  O  O     . TYR A 1 470 ? -1.459  8.223   -26.35   1    33.873  ? 470  TYR A O     1 ? 
ATOM   3272  C  CB    . TYR A 1 470 ? -4.211  9.164   -27.799  1    24.17   ? 470  TYR A CB    1 ? 
ATOM   3273  C  CG    . TYR A 1 470 ? -5.603  8.599   -27.588  1    27.117  ? 470  TYR A CG    1 ? 
ATOM   3274  C  CD1   . TYR A 1 470 ? -6.636  9.381   -27.068  1    26.244  ? 470  TYR A CD1   1 ? 
ATOM   3275  C  CD2   . TYR A 1 470 ? -5.856  7.26    -27.836  1    32.393  ? 470  TYR A CD2   1 ? 
ATOM   3276  C  CE1   . TYR A 1 470 ? -7.897  8.856   -26.821  1    27.262  ? 470  TYR A CE1   1 ? 
ATOM   3277  C  CE2   . TYR A 1 470 ? -7.111  6.718   -27.592  1    37.965  ? 470  TYR A CE2   1 ? 
ATOM   3278  C  CZ    . TYR A 1 470 ? -8.127  7.518   -27.082  1    32.463  ? 470  TYR A CZ    1 ? 
ATOM   3279  O  OH    . TYR A 1 470 ? -9.358  6.977   -26.886  1    38.926  ? 470  TYR A OH    1 ? 
ATOM   3280  N  N     . TYR A 1 471 ? -1.312  10.315  -27.157  1    26.892  ? 471  TYR A N     1 ? 
ATOM   3281  C  CA    . TYR A 1 471 ? 0.063   10.189  -27.64   1    27.614  ? 471  TYR A CA    1 ? 
ATOM   3282  C  C     . TYR A 1 471 ? 1.064   10.657  -26.584  1    27.692  ? 471  TYR A C     1 ? 
ATOM   3283  O  O     . TYR A 1 471 ? 2.154   10.122  -26.513  1    28.299  ? 471  TYR A O     1 ? 
ATOM   3284  C  CB    . TYR A 1 471 ? 0.314   10.971  -28.945  1    27.144  ? 471  TYR A CB    1 ? 
ATOM   3285  C  CG    . TYR A 1 471 ? -0.227  10.254  -30.175  1    27.798  ? 471  TYR A CG    1 ? 
ATOM   3286  C  CD1   . TYR A 1 471 ? -1.579  10.315  -30.48   1    28.127  ? 471  TYR A CD1   1 ? 
ATOM   3287  C  CD2   . TYR A 1 471 ? 0.588   9.447   -30.965  1    28.321  ? 471  TYR A CD2   1 ? 
ATOM   3288  C  CE1   . TYR A 1 471 ? -2.114  9.586   -31.521  1    30.049  ? 471  TYR A CE1   1 ? 
ATOM   3289  C  CE2   . TYR A 1 471 ? 0.068   8.735   -32.033  1    29.538  ? 471  TYR A CE2   1 ? 
ATOM   3290  C  CZ    . TYR A 1 471 ? -1.286  8.804   -32.305  1    30.23   ? 471  TYR A CZ    1 ? 
ATOM   3291  O  OH    . TYR A 1 471 ? -1.857  8.168   -33.363  1    29.523  ? 471  TYR A OH    1 ? 
ATOM   3292  N  N     . HIS A 1 472 ? 0.733   11.731  -25.856  1    24.946  ? 472  HIS A N     1 ? 
ATOM   3293  C  CA    . HIS A 1 472 ? 1.671   12.389  -24.969  1    27.068  ? 472  HIS A CA    1 ? 
ATOM   3294  C  C     . HIS A 1 472 ? 1.21    12.32   -23.51   1    26.834  ? 472  HIS A C     1 ? 
ATOM   3295  O  O     . HIS A 1 472 ? 1.97    12.705  -22.639  1    30.569  ? 472  HIS A O     1 ? 
ATOM   3296  C  CB    . HIS A 1 472 ? 1.871   13.856  -25.369  1    27.899  ? 472  HIS A CB    1 ? 
ATOM   3297  C  CG    . HIS A 1 472 ? 2.261   14.006  -26.792  1    34.085  ? 472  HIS A CG    1 ? 
ATOM   3298  N  ND1   . HIS A 1 472 ? 1.611   14.834  -27.687  1    33.361  ? 472  HIS A ND1   1 ? 
ATOM   3299  C  CD2   . HIS A 1 472 ? 3.168   13.341  -27.489  1    34.033  ? 472  HIS A CD2   1 ? 
ATOM   3300  C  CE1   . HIS A 1 472 ? 2.139   14.681  -28.878  1    32.852  ? 472  HIS A CE1   1 ? 
ATOM   3301  N  NE2   . HIS A 1 472 ? 3.075   13.772  -28.779  1    33.294  ? 472  HIS A NE2   1 ? 
ATOM   3302  N  N     . GLY A 1 473 ? -0.021  11.86   -23.222  1    26.595  ? 473  GLY A N     1 ? 
ATOM   3303  C  CA    . GLY A 1 473 ? -0.576  12.032  -21.876  1    21.517  ? 473  GLY A CA    1 ? 
ATOM   3304  C  C     . GLY A 1 473 ? -1.319  13.373  -21.791  1    23.883  ? 473  GLY A C     1 ? 
ATOM   3305  O  O     . GLY A 1 473 ? -1.04   14.287  -22.588  1    25.506  ? 473  GLY A O     1 ? 
ATOM   3306  N  N     . VAL A 1 474 ? -2.277  13.478  -20.853  1    22.72   ? 474  VAL A N     1 ? 
ATOM   3307  C  CA    A VAL A 1 474 ? -3.11   14.661  -20.727  0.5  21.805  ? 474  VAL A CA    1 ? 
ATOM   3308  C  CA    B VAL A 1 474 ? -3.102  14.668  -20.662  0.5  22.504  ? 474  VAL A CA    1 ? 
ATOM   3309  C  C     . VAL A 1 474 ? -2.228  15.919  -20.782  1    23.58   ? 474  VAL A C     1 ? 
ATOM   3310  O  O     . VAL A 1 474 ? -1.222  16.039  -20.073  1    22.536  ? 474  VAL A O     1 ? 
ATOM   3311  C  CB    A VAL A 1 474 ? -3.988  14.555  -19.457  0.5  21.605  ? 474  VAL A CB    1 ? 
ATOM   3312  C  CB    B VAL A 1 474 ? -3.766  14.657  -19.267  0.5  23.285  ? 474  VAL A CB    1 ? 
ATOM   3313  C  CG1   A VAL A 1 474 ? -3.18   14.413  -18.164  0.5  19.13   ? 474  VAL A CG1   1 ? 
ATOM   3314  C  CG1   B VAL A 1 474 ? -4.676  15.865  -19.041  0.5  21.972  ? 474  VAL A CG1   1 ? 
ATOM   3315  C  CG2   A VAL A 1 474 ? -4.997  15.7    -19.346  0.5  20.22   ? 474  VAL A CG2   1 ? 
ATOM   3316  C  CG2   B VAL A 1 474 ? -4.521  13.375  -18.979  0.5  21.503  ? 474  VAL A CG2   1 ? 
ATOM   3317  N  N     . GLN A 1 475 ? -2.645  16.908  -21.602  1    22.206  ? 475  GLN A N     1 ? 
ATOM   3318  C  CA    . GLN A 1 475 ? -1.884  18.151  -21.691  1    24.908  ? 475  GLN A CA    1 ? 
ATOM   3319  C  C     . GLN A 1 475 ? -2.691  19.331  -21.139  1    24.784  ? 475  GLN A C     1 ? 
ATOM   3320  O  O     . GLN A 1 475 ? -2.17   20.437  -21.071  1    22.569  ? 475  GLN A O     1 ? 
ATOM   3321  C  CB    . GLN A 1 475 ? -1.389  18.404  -23.127  1    28.028  ? 475  GLN A CB    1 ? 
ATOM   3322  C  CG    . GLN A 1 475 ? -0.311  17.411  -23.58   1    29.19   ? 475  GLN A CG    1 ? 
ATOM   3323  C  CD    . GLN A 1 475 ? 0.871   17.432  -22.638  1    28.905  ? 475  GLN A CD    1 ? 
ATOM   3324  O  OE1   . GLN A 1 475 ? 1.323   18.519  -22.258  1    28.748  ? 475  GLN A OE1   1 ? 
ATOM   3325  N  NE2   . GLN A 1 475 ? 1.337   16.265  -22.203  1    27.909  ? 475  GLN A NE2   1 ? 
ATOM   3326  N  N     . SER A 1 476 ? -3.965  19.107  -20.768  1    20.379  ? 476  SER A N     1 ? 
ATOM   3327  C  CA    . SER A 1 476 ? -4.694  20.056  -19.929  1    20.018  ? 476  SER A CA    1 ? 
ATOM   3328  C  C     . SER A 1 476 ? -5.749  19.322  -19.1    1    19.243  ? 476  SER A C     1 ? 
ATOM   3329  O  O     . SER A 1 476 ? -6.601  18.622  -19.652  1    17.192  ? 476  SER A O     1 ? 
ATOM   3330  C  CB    . SER A 1 476 ? -5.376  21.073  -20.769  1    22.838  ? 476  SER A CB    1 ? 
ATOM   3331  O  OG    . SER A 1 476 ? -6.301  21.834  -19.988  1    22.476  ? 476  SER A OG    1 ? 
ATOM   3332  N  N     . TRP A 1 477 ? -5.673  19.491  -17.786  1    18.97   ? 477  TRP A N     1 ? 
ATOM   3333  C  CA    . TRP A 1 477 ? -6.648  18.895  -16.891  1    21.963  ? 477  TRP A CA    1 ? 
ATOM   3334  C  C     . TRP A 1 477 ? -7.967  19.679  -16.913  1    21.123  ? 477  TRP A C     1 ? 
ATOM   3335  O  O     . TRP A 1 477 ? -8.975  19.138  -16.492  1    20.656  ? 477  TRP A O     1 ? 
ATOM   3336  C  CB    . TRP A 1 477 ? -6.049  18.794  -15.481  1    19.392  ? 477  TRP A CB    1 ? 
ATOM   3337  C  CG    . TRP A 1 477 ? -5.154  17.591  -15.31   1    19.069  ? 477  TRP A CG    1 ? 
ATOM   3338  C  CD1   . TRP A 1 477 ? -3.793  17.578  -15.523  1    19.134  ? 477  TRP A CD1   1 ? 
ATOM   3339  C  CD2   . TRP A 1 477 ? -5.535  16.239  -14.959  1    17.404  ? 477  TRP A CD2   1 ? 
ATOM   3340  N  NE1   . TRP A 1 477 ? -3.304  16.323  -15.282  1    21.331  ? 477  TRP A NE1   1 ? 
ATOM   3341  C  CE2   . TRP A 1 477 ? -4.348  15.472  -14.968  1    19.447  ? 477  TRP A CE2   1 ? 
ATOM   3342  C  CE3   . TRP A 1 477 ? -6.759  15.604  -14.666  1    18.244  ? 477  TRP A CE3   1 ? 
ATOM   3343  C  CZ2   . TRP A 1 477 ? -4.346  14.102  -14.673  1    19.457  ? 477  TRP A CZ2   1 ? 
ATOM   3344  C  CZ3   . TRP A 1 477 ? -6.774  14.254  -14.4    1    18.142  ? 477  TRP A CZ3   1 ? 
ATOM   3345  C  CH2   . TRP A 1 477 ? -5.581  13.516  -14.411  1    19.543  ? 477  TRP A CH2   1 ? 
ATOM   3346  N  N     . SER A 1 478 ? -7.95   20.96   -17.355  1    20.12   ? 478  SER A N     1 ? 
ATOM   3347  C  CA    . SER A 1 478 ? -9.127  21.82   -17.282  1    21.254  ? 478  SER A CA    1 ? 
ATOM   3348  C  C     . SER A 1 478 ? -9.896  21.906  -18.606  1    25.084  ? 478  SER A C     1 ? 
ATOM   3349  O  O     . SER A 1 478 ? -11.105 22.184  -18.564  1    20.836  ? 478  SER A O     1 ? 
ATOM   3350  C  CB    . SER A 1 478 ? -8.826  23.229  -16.802  1    22.67   ? 478  SER A CB    1 ? 
ATOM   3351  O  OG    . SER A 1 478 ? -7.971  23.85   -17.757  1    23.303  ? 478  SER A OG    1 ? 
ATOM   3352  N  N     . TRP A 1 479 ? -9.233  21.685  -19.768  1    20.894  ? 479  TRP A N     1 ? 
ATOM   3353  C  CA    . TRP A 1 479 ? -9.926  21.866  -21.047  1    22.151  ? 479  TRP A CA    1 ? 
ATOM   3354  C  C     . TRP A 1 479 ? -11.17  20.975  -21.174  1    21.847  ? 479  TRP A C     1 ? 
ATOM   3355  O  O     . TRP A 1 479 ? -11.14  19.816  -20.783  1    23.312  ? 479  TRP A O     1 ? 
ATOM   3356  C  CB    . TRP A 1 479 ? -8.992  21.6    -22.251  1    23.097  ? 479  TRP A CB    1 ? 
ATOM   3357  C  CG    . TRP A 1 479 ? -9.776  21.659  -23.538  1    23.344  ? 479  TRP A CG    1 ? 
ATOM   3358  C  CD1   . TRP A 1 479 ? -10.026 22.785  -24.263  1    22.217  ? 479  TRP A CD1   1 ? 
ATOM   3359  C  CD2   . TRP A 1 479 ? -10.493 20.577  -24.189  1    22.833  ? 479  TRP A CD2   1 ? 
ATOM   3360  N  NE1   . TRP A 1 479 ? -10.824 22.471  -25.334  1    25.526  ? 479  TRP A NE1   1 ? 
ATOM   3361  C  CE2   . TRP A 1 479 ? -11.133 21.134  -25.311  1    25.711  ? 479  TRP A CE2   1 ? 
ATOM   3362  C  CE3   . TRP A 1 479 ? -10.631 19.201  -23.951  1    23.151  ? 479  TRP A CE3   1 ? 
ATOM   3363  C  CZ2   . TRP A 1 479 ? -11.919 20.365  -26.165  1    27.213  ? 479  TRP A CZ2   1 ? 
ATOM   3364  C  CZ3   . TRP A 1 479 ? -11.397 18.431  -24.796  1    24.288  ? 479  TRP A CZ3   1 ? 
ATOM   3365  C  CH2   . TRP A 1 479 ? -12.063 19.021  -25.878  1    26.321  ? 479  TRP A CH2   1 ? 
ATOM   3366  N  N     . TYR A 1 480 ? -12.24  21.463  -21.808  1    21.453  ? 480  TYR A N     1 ? 
ATOM   3367  C  CA    . TYR A 1 480 ? -13.368 20.587  -22.115  1    23.626  ? 480  TYR A CA    1 ? 
ATOM   3368  C  C     . TYR A 1 480 ? -14.102 21.123  -23.349  1    21.878  ? 480  TYR A C     1 ? 
ATOM   3369  O  O     . TYR A 1 480 ? -14.066 22.304  -23.594  1    22.742  ? 480  TYR A O     1 ? 
ATOM   3370  C  CB    . TYR A 1 480 ? -14.349 20.505  -20.931  1    23.455  ? 480  TYR A CB    1 ? 
ATOM   3371  C  CG    . TYR A 1 480 ? -15.095 21.796  -20.601  1    26.809  ? 480  TYR A CG    1 ? 
ATOM   3372  C  CD1   . TYR A 1 480 ? -14.493 22.771  -19.812  1    34.281  ? 480  TYR A CD1   1 ? 
ATOM   3373  C  CD2   . TYR A 1 480 ? -16.403 22.034  -21.04   1    25.589  ? 480  TYR A CD2   1 ? 
ATOM   3374  C  CE1   . TYR A 1 480 ? -15.146 23.952  -19.495  1    33.162  ? 480  TYR A CE1   1 ? 
ATOM   3375  C  CE2   . TYR A 1 480 ? -17.07  23.215  -20.738  1    25.411  ? 480  TYR A CE2   1 ? 
ATOM   3376  C  CZ    . TYR A 1 480 ? -16.45  24.155  -19.926  1    35.491  ? 480  TYR A CZ    1 ? 
ATOM   3377  O  OH    . TYR A 1 480 ? -17.039 25.345  -19.582  1    43.134  ? 480  TYR A OH    1 ? 
ATOM   3378  N  N     . TYR A 1 481 ? -14.803 20.272  -24.093  1    21.742  ? 481  TYR A N     1 ? 
ATOM   3379  C  CA    . TYR A 1 481 ? -15.615 20.741  -25.203  1    23.275  ? 481  TYR A CA    1 ? 
ATOM   3380  C  C     . TYR A 1 481 ? -16.899 21.389  -24.678  1    24.701  ? 481  TYR A C     1 ? 
ATOM   3381  O  O     . TYR A 1 481 ? -17.658 20.727  -24.002  1    26.063  ? 481  TYR A O     1 ? 
ATOM   3382  C  CB    . TYR A 1 481 ? -15.936 19.569  -26.142  1    24.225  ? 481  TYR A CB    1 ? 
ATOM   3383  C  CG    . TYR A 1 481 ? -16.457 20.073  -27.485  1    25.697  ? 481  TYR A CG    1 ? 
ATOM   3384  C  CD1   . TYR A 1 481 ? -15.56  20.52   -28.452  1    27.81   ? 481  TYR A CD1   1 ? 
ATOM   3385  C  CD2   . TYR A 1 481 ? -17.82  20.166  -27.76   1    23.324  ? 481  TYR A CD2   1 ? 
ATOM   3386  C  CE1   . TYR A 1 481 ? -15.986 21.018  -29.677  1    28.571  ? 481  TYR A CE1   1 ? 
ATOM   3387  C  CE2   . TYR A 1 481 ? -18.269 20.681  -28.98   1    28.09   ? 481  TYR A CE2   1 ? 
ATOM   3388  C  CZ    . TYR A 1 481 ? -17.348 21.132  -29.922  1    30.212  ? 481  TYR A CZ    1 ? 
ATOM   3389  O  OH    . TYR A 1 481 ? -17.705 21.616  -31.142  1    33.606  ? 481  TYR A OH    1 ? 
ATOM   3390  N  N     . PRO A 1 482 ? -17.197 22.682  -24.963  1    25.234  ? 482  PRO A N     1 ? 
ATOM   3391  C  CA    . PRO A 1 482 ? -18.307 23.372  -24.295  1    24.76   ? 482  PRO A CA    1 ? 
ATOM   3392  C  C     . PRO A 1 482 ? -19.711 23.326  -24.897  1    26.319  ? 482  PRO A C     1 ? 
ATOM   3393  O  O     . PRO A 1 482 ? -20.558 24.094  -24.49   1    27.42   ? 482  PRO A O     1 ? 
ATOM   3394  C  CB    . PRO A 1 482 ? -17.745 24.806  -24.234  1    27.172  ? 482  PRO A CB    1 ? 
ATOM   3395  C  CG    . PRO A 1 482 ? -17.025 24.964  -25.567  1    26.527  ? 482  PRO A CG    1 ? 
ATOM   3396  C  CD    . PRO A 1 482 ? -16.391 23.586  -25.814  1    23.839  ? 482  PRO A CD    1 ? 
ATOM   3397  N  N     . TYR A 1 483 ? -19.99  22.382  -25.801  1    25.656  ? 483  TYR A N     1 ? 
ATOM   3398  C  CA    . TYR A 1 483 ? -21.331 22.281  -26.368  1    23.816  ? 483  TYR A CA    1 ? 
ATOM   3399  C  C     . TYR A 1 483 ? -21.704 20.818  -26.405  1    24.328  ? 483  TYR A C     1 ? 
ATOM   3400  O  O     . TYR A 1 483 ? -20.829 19.974  -26.524  1    24.914  ? 483  TYR A O     1 ? 
ATOM   3401  C  CB    . TYR A 1 483 ? -21.414 22.781  -27.823  1    26.806  ? 483  TYR A CB    1 ? 
ATOM   3402  C  CG    . TYR A 1 483 ? -21.027 24.245  -27.911  1    30.642  ? 483  TYR A CG    1 ? 
ATOM   3403  C  CD1   . TYR A 1 483 ? -21.97  25.232  -27.635  1    34.216  ? 483  TYR A CD1   1 ? 
ATOM   3404  C  CD2   . TYR A 1 483 ? -19.72  24.634  -28.173  1    32.045  ? 483  TYR A CD2   1 ? 
ATOM   3405  C  CE1   . TYR A 1 483 ? -21.639 26.578  -27.65   1    38.234  ? 483  TYR A CE1   1 ? 
ATOM   3406  C  CE2   . TYR A 1 483 ? -19.379 25.981  -28.205  1    33.523  ? 483  TYR A CE2   1 ? 
ATOM   3407  C  CZ    . TYR A 1 483 ? -20.34  26.949  -27.948  1    37.178  ? 483  TYR A CZ    1 ? 
ATOM   3408  O  OH    . TYR A 1 483 ? -20.041 28.281  -27.938  1    39.242  ? 483  TYR A OH    1 ? 
ATOM   3409  N  N     . HIS A 1 484 ? -23.016 20.541  -26.396  1    26.146  ? 484  HIS A N     1 ? 
ATOM   3410  C  CA    . HIS A 1 484 ? -23.515 19.18   -26.335  1    25.583  ? 484  HIS A CA    1 ? 
ATOM   3411  C  C     . HIS A 1 484 ? -23.545 18.539  -27.727  1    25.877  ? 484  HIS A C     1 ? 
ATOM   3412  O  O     . HIS A 1 484 ? -23.78  17.326  -27.854  1    25.583  ? 484  HIS A O     1 ? 
ATOM   3413  C  CB    . HIS A 1 484 ? -24.939 19.178  -25.752  1    26.821  ? 484  HIS A CB    1 ? 
ATOM   3414  C  CG    . HIS A 1 484 ? -25.012 19.505  -24.305  1    26.137  ? 484  HIS A CG    1 ? 
ATOM   3415  N  ND1   . HIS A 1 484 ? -24.548 18.621  -23.349  1    25.452  ? 484  HIS A ND1   1 ? 
ATOM   3416  C  CD2   . HIS A 1 484 ? -25.484 20.572  -23.645  1    23.195  ? 484  HIS A CD2   1 ? 
ATOM   3417  C  CE1   . HIS A 1 484 ? -24.725 19.16   -22.158  1    23.613  ? 484  HIS A CE1   1 ? 
ATOM   3418  N  NE2   . HIS A 1 484 ? -25.272 20.349  -22.323  1    23.742  ? 484  HIS A NE2   1 ? 
ATOM   3419  N  N     . TYR A 1 485 ? -23.26  19.329  -28.767  1    26.065  ? 485  TYR A N     1 ? 
ATOM   3420  C  CA    . TYR A 1 485 ? -23.393 18.902  -30.166  1    27.605  ? 485  TYR A CA    1 ? 
ATOM   3421  C  C     . TYR A 1 485 ? -22.179 19.41   -30.94   1    25.256  ? 485  TYR A C     1 ? 
ATOM   3422  O  O     . TYR A 1 485 ? -21.644 20.45   -30.589  1    24.513  ? 485  TYR A O     1 ? 
ATOM   3423  C  CB    . TYR A 1 485 ? -24.664 19.528  -30.782  1    27.913  ? 485  TYR A CB    1 ? 
ATOM   3424  C  CG    . TYR A 1 485 ? -25.92  18.957  -30.142  1    28.975  ? 485  TYR A CG    1 ? 
ATOM   3425  C  CD1   . TYR A 1 485 ? -26.428 17.732  -30.54   1    29.733  ? 485  TYR A CD1   1 ? 
ATOM   3426  C  CD2   . TYR A 1 485 ? -26.526 19.593  -29.065  1    31.183  ? 485  TYR A CD2   1 ? 
ATOM   3427  C  CE1   . TYR A 1 485 ? -27.529 17.168  -29.921  1    33.59   ? 485  TYR A CE1   1 ? 
ATOM   3428  C  CE2   . TYR A 1 485 ? -27.654 19.057  -28.463  1    30.921  ? 485  TYR A CE2   1 ? 
ATOM   3429  C  CZ    . TYR A 1 485 ? -28.143 17.839  -28.877  1    33.86   ? 485  TYR A CZ    1 ? 
ATOM   3430  O  OH    . TYR A 1 485 ? -29.245 17.319  -28.262  1    36.86   ? 485  TYR A OH    1 ? 
ATOM   3431  N  N     . ALA A 1 486 ? -21.77  18.706  -32.013  1    29.455  ? 486  ALA A N     1 ? 
ATOM   3432  C  CA    . ALA A 1 486 ? -20.63  19.141  -32.818  1    30.029  ? 486  ALA A CA    1 ? 
ATOM   3433  C  C     . ALA A 1 486 ? -21.097 20.094  -33.93   1    30.9    ? 486  ALA A C     1 ? 
ATOM   3434  O  O     . ALA A 1 486 ? -22.287 20.117  -34.258  1    31.869  ? 486  ALA A O     1 ? 
ATOM   3435  C  CB    . ALA A 1 486 ? -19.923 17.93   -33.386  1    31.641  ? 486  ALA A CB    1 ? 
ATOM   3436  N  N     . PRO A 1 487 ? -20.202 20.898  -34.553  1    30.974  ? 487  PRO A N     1 ? 
ATOM   3437  C  CA    . PRO A 1 487 ? -20.57  21.735  -35.7    1    32.372  ? 487  PRO A CA    1 ? 
ATOM   3438  C  C     . PRO A 1 487 ? -20.775 20.856  -36.922  1    34.57   ? 487  PRO A C     1 ? 
ATOM   3439  O  O     . PRO A 1 487 ? -20.301 19.718  -36.948  1    31.244  ? 487  PRO A O     1 ? 
ATOM   3440  C  CB    . PRO A 1 487 ? -19.37  22.698  -35.941  1    30.133  ? 487  PRO A CB    1 ? 
ATOM   3441  C  CG    . PRO A 1 487 ? -18.341 22.355  -34.853  1    30.429  ? 487  PRO A CG    1 ? 
ATOM   3442  C  CD    . PRO A 1 487 ? -18.779 21.044  -34.205  1    31.513  ? 487  PRO A CD    1 ? 
ATOM   3443  N  N     . PHE A 1 488 ? -21.452 21.397  -37.951  1    32.42   ? 488  PHE A N     1 ? 
ATOM   3444  C  CA    . PHE A 1 488 ? -21.427 20.735  -39.255  1    28.476  ? 488  PHE A CA    1 ? 
ATOM   3445  C  C     . PHE A 1 488 ? -20.008 20.702  -39.811  1    27.011  ? 488  PHE A C     1 ? 
ATOM   3446  O  O     . PHE A 1 488 ? -19.251 21.668  -39.73   1    28.464  ? 488  PHE A O     1 ? 
ATOM   3447  C  CB    . PHE A 1 488 ? -22.344 21.36   -40.302  1    28.928  ? 488  PHE A CB    1 ? 
ATOM   3448  C  CG    . PHE A 1 488 ? -23.794 20.965  -40.101  1    30.684  ? 488  PHE A CG    1 ? 
ATOM   3449  C  CD1   . PHE A 1 488 ? -24.631 21.727  -39.294  1    34.306  ? 488  PHE A CD1   1 ? 
ATOM   3450  C  CD2   . PHE A 1 488 ? -24.334 19.893  -40.807  1    35.448  ? 488  PHE A CD2   1 ? 
ATOM   3451  C  CE1   . PHE A 1 488 ? -25.96  21.362  -39.129  1    36.813  ? 488  PHE A CE1   1 ? 
ATOM   3452  C  CE2   . PHE A 1 488 ? -25.672 19.551  -40.671  1    37.972  ? 488  PHE A CE2   1 ? 
ATOM   3453  C  CZ    . PHE A 1 488 ? -26.476 20.266  -39.804  1    37.422  ? 488  PHE A CZ    1 ? 
ATOM   3454  N  N     . LEU A 1 489 ? -19.653 19.554  -40.379  1    30.233  ? 489  LEU A N     1 ? 
ATOM   3455  C  CA    . LEU A 1 489 ? -18.363 19.36   -41.021  1    35.387  ? 489  LEU A CA    1 ? 
ATOM   3456  C  C     . LEU A 1 489 ? -18.079 20.475  -42.027  1    36.642  ? 489  LEU A C     1 ? 
ATOM   3457  O  O     . LEU A 1 489 ? -16.916 20.852  -42.189  1    31.591  ? 489  LEU A O     1 ? 
ATOM   3458  C  CB    . LEU A 1 489 ? -18.485 17.984  -41.676  1    38.403  ? 489  LEU A CB    1 ? 
ATOM   3459  C  CG    . LEU A 1 489 ? -17.212 17.309  -42.182  1    42.874  ? 489  LEU A CG    1 ? 
ATOM   3460  C  CD1   . LEU A 1 489 ? -16.001 17.519  -41.327  1    40.733  ? 489  LEU A CD1   1 ? 
ATOM   3461  C  CD2   . LEU A 1 489 ? -17.571 15.851  -42.228  1    45.739  ? 489  LEU A CD2   1 ? 
ATOM   3462  N  N     . SER A 1 490 ? -19.138 21.051  -42.633  1    34.919  ? 490  SER A N     1 ? 
ATOM   3463  C  CA    . SER A 1 490 ? -19.006 22.085  -43.66   1    35.825  ? 490  SER A CA    1 ? 
ATOM   3464  C  C     . SER A 1 490 ? -18.73  23.45   -43.06   1    41.228  ? 490  SER A C     1 ? 
ATOM   3465  O  O     . SER A 1 490 ? -18.39  24.391  -43.795  1    37.565  ? 490  SER A O     1 ? 
ATOM   3466  C  CB    . SER A 1 490 ? -20.194 22.192  -44.557  1    35.421  ? 490  SER A CB    1 ? 
ATOM   3467  O  OG    . SER A 1 490 ? -21.395 22.299  -43.805  1    35.645  ? 490  SER A OG    1 ? 
ATOM   3468  N  N     . ASP A 1 491 ? -18.867 23.553  -41.73   1    35.317  ? 491  ASP A N     1 ? 
ATOM   3469  C  CA    . ASP A 1 491 ? -18.549 24.825  -41.119  1    34.42   ? 491  ASP A CA    1 ? 
ATOM   3470  C  C     . ASP A 1 491 ? -17.138 24.807  -40.56   1    33.788  ? 491  ASP A C     1 ? 
ATOM   3471  O  O     . ASP A 1 491 ? -16.679 25.818  -40.034  1    39.572  ? 491  ASP A O     1 ? 
ATOM   3472  C  CB    . ASP A 1 491 ? -19.602 25.273  -40.12   1    33.387  ? 491  ASP A CB    1 ? 
ATOM   3473  C  CG    . ASP A 1 491 ? -20.999 25.42   -40.698  1    39.926  ? 491  ASP A CG    1 ? 
ATOM   3474  O  OD1   . ASP A 1 491 ? -21.105 26.028  -41.779  1    45.566  ? 491  ASP A OD1   1 ? 
ATOM   3475  O  OD2   . ASP A 1 491 ? -21.96  24.91   -40.075  1    35.41   ? 491  ASP A OD2   1 ? 
ATOM   3476  N  N     . ILE A 1 492 ? -16.459 23.664  -40.646  1    35.197  ? 492  ILE A N     1 ? 
ATOM   3477  C  CA    . ILE A 1 492 ? -15.149 23.594  -40.013  1    36.229  ? 492  ILE A CA    1 ? 
ATOM   3478  C  C     . ILE A 1 492 ? -14.064 23.934  -41.037  1    36.211  ? 492  ILE A C     1 ? 
ATOM   3479  O  O     . ILE A 1 492 ? -13.535 23.068  -41.741  1    36.684  ? 492  ILE A O     1 ? 
ATOM   3480  C  CB    . ILE A 1 492 ? -14.938 22.242  -39.284  1    34.247  ? 492  ILE A CB    1 ? 
ATOM   3481  C  CG1   . ILE A 1 492 ? -16.028 22.01   -38.224  1    31.538  ? 492  ILE A CG1   1 ? 
ATOM   3482  C  CG2   . ILE A 1 492 ? -13.54  22.176  -38.673  1    29.315  ? 492  ILE A CG2   1 ? 
ATOM   3483  C  CD1   . ILE A 1 492 ? -16.166 20.577  -37.757  1    31.107  ? 492  ILE A CD1   1 ? 
ATOM   3484  N  N     . HIS A 1 493 ? -13.737 25.223  -41.111  1    38.279  ? 493  HIS A N     1 ? 
ATOM   3485  C  CA    . HIS A 1 493 ? -12.762 25.734  -42.063  1    40.563  ? 493  HIS A CA    1 ? 
ATOM   3486  C  C     . HIS A 1 493 ? -12.257 27.061  -41.523  1    39.571  ? 493  HIS A C     1 ? 
ATOM   3487  O  O     . HIS A 1 493 ? -12.806 27.569  -40.541  1    41.276  ? 493  HIS A O     1 ? 
ATOM   3488  C  CB    . HIS A 1 493 ? -13.358 25.921  -43.465  1    37.308  ? 493  HIS A CB    1 ? 
ATOM   3489  C  CG    . HIS A 1 493 ? -14.562 26.822  -43.441  1    37.693  ? 493  HIS A CG    1 ? 
ATOM   3490  N  ND1   . HIS A 1 493 ? -14.487 28.197  -43.366  1    37.191  ? 493  HIS A ND1   1 ? 
ATOM   3491  C  CD2   . HIS A 1 493 ? -15.874 26.525  -43.402  1    36.379  ? 493  HIS A CD2   1 ? 
ATOM   3492  C  CE1   . HIS A 1 493 ? -15.712 28.712  -43.302  1    32.788  ? 493  HIS A CE1   1 ? 
ATOM   3493  N  NE2   . HIS A 1 493 ? -16.568 27.711  -43.334  1    35.831  ? 493  HIS A NE2   1 ? 
ATOM   3494  N  N     . ASN A 1 494 ? -11.2   27.575  -42.163  1    39.119  ? 494  ASN A N     1 ? 
ATOM   3495  C  CA    . ASN A 1 494 ? -10.505 28.782  -41.745  1    43.798  ? 494  ASN A CA    1 ? 
ATOM   3496  C  C     . ASN A 1 494 ? -9.706  28.559  -40.461  1    43.013  ? 494  ASN A C     1 ? 
ATOM   3497  O  O     . ASN A 1 494 ? -9.637  29.445  -39.61   1    41.764  ? 494  ASN A O     1 ? 
ATOM   3498  C  CB    . ASN A 1 494 ? -11.434 29.989  -41.656  1    48.613  ? 494  ASN A CB    1 ? 
ATOM   3499  C  CG    . ASN A 1 494 ? -11.252 30.898  -42.84   1    62.951  ? 494  ASN A CG    1 ? 
ATOM   3500  O  OD1   . ASN A 1 494 ? -11.615 30.537  -43.969  1    67.575  ? 494  ASN A OD1   1 ? 
ATOM   3501  N  ND2   . ASN A 1 494 ? -10.657 32.055  -42.596  1    68.14   ? 494  ASN A ND2   1 ? 
ATOM   3502  N  N     . ILE A 1 495 ? -9.051  27.403  -40.347  1    45.627  ? 495  ILE A N     1 ? 
ATOM   3503  C  CA    . ILE A 1 495 ? -8.45   27.008  -39.074  1    44.873  ? 495  ILE A CA    1 ? 
ATOM   3504  C  C     . ILE A 1 495 ? -6.954  26.804  -39.267  1    46.916  ? 495  ILE A C     1 ? 
ATOM   3505  O  O     . ILE A 1 495 ? -6.296  26.298  -38.367  1    44.589  ? 495  ILE A O     1 ? 
ATOM   3506  C  CB    . ILE A 1 495 ? -9.05   25.675  -38.595  1    45.931  ? 495  ILE A CB    1 ? 
ATOM   3507  C  CG1   . ILE A 1 495 ? -8.753  24.568  -39.639  1    44.651  ? 495  ILE A CG1   1 ? 
ATOM   3508  C  CG2   . ILE A 1 495 ? -10.53  25.816  -38.237  1    44.846  ? 495  ILE A CG2   1 ? 
ATOM   3509  C  CD1   . ILE A 1 495 ? -9.303  23.188  -39.352  1    52.293  ? 495  ILE A CD1   1 ? 
ATOM   3510  N  N     . SER A 1 496 ? -6.427  27.144  -40.452  1    51.245  ? 496  SER A N     1 ? 
ATOM   3511  C  CA    . SER A 1 496 ? -5.116  26.653  -40.842  1    44.321  ? 496  SER A CA    1 ? 
ATOM   3512  C  C     . SER A 1 496 ? -4.033  27.241  -39.957  1    39.726  ? 496  SER A C     1 ? 
ATOM   3513  O  O     . SER A 1 496 ? -3.013  26.602  -39.75   1    41.904  ? 496  SER A O     1 ? 
ATOM   3514  C  CB    . SER A 1 496 ? -4.813  26.89   -42.302  1    48.442  ? 496  SER A CB    1 ? 
ATOM   3515  O  OG    . SER A 1 496 ? -5.63   26.045  -43.098  1    58.532  ? 496  SER A OG    1 ? 
ATOM   3516  N  N     . THR A 1 497 ? -4.231  28.475  -39.489  1    38.058  ? 497  THR A N     1 ? 
ATOM   3517  C  CA    . THR A 1 497 ? -3.117  29.131  -38.825  1    47.078  ? 497  THR A CA    1 ? 
ATOM   3518  C  C     . THR A 1 497 ? -3.459  29.36   -37.358  1    48.025  ? 497  THR A C     1 ? 
ATOM   3519  O  O     . THR A 1 497 ? -2.72   30.062  -36.669  1    49.85   ? 497  THR A O     1 ? 
ATOM   3520  C  CB    . THR A 1 497 ? -2.694  30.425  -39.532  1    44.896  ? 497  THR A CB    1 ? 
ATOM   3521  O  OG1   . THR A 1 497 ? -3.765  31.357  -39.389  1    46.976  ? 497  THR A OG1   1 ? 
ATOM   3522  C  CG2   . THR A 1 497 ? -2.327  30.202  -40.987  1    45.701  ? 497  THR A CG2   1 ? 
ATOM   3523  N  N     . LEU A 1 498 ? -4.572  28.754  -36.919  1    47.41   ? 498  LEU A N     1 ? 
ATOM   3524  C  CA    . LEU A 1 498 ? -5.061  28.786  -35.544  1    50.715  ? 498  LEU A CA    1 ? 
ATOM   3525  C  C     . LEU A 1 498 ? -3.936  28.499  -34.552  1    43.847  ? 498  LEU A C     1 ? 
ATOM   3526  O  O     . LEU A 1 498 ? -3.161  27.573  -34.734  1    41.226  ? 498  LEU A O     1 ? 
ATOM   3527  C  CB    . LEU A 1 498 ? -6.171  27.742  -35.435  1    53.054  ? 498  LEU A CB    1 ? 
ATOM   3528  C  CG    . LEU A 1 498 ? -6.89   27.623  -34.088  1    59.861  ? 498  LEU A CG    1 ? 
ATOM   3529  C  CD1   . LEU A 1 498 ? -7.532  28.944  -33.653  1    63.945  ? 498  LEU A CD1   1 ? 
ATOM   3530  C  CD2   . LEU A 1 498 ? -7.923  26.501  -34.162  1    50.345  ? 498  LEU A CD2   1 ? 
ATOM   3531  N  N     . LYS A 1 499 ? -3.863  29.305  -33.49   1    44.722  ? 499  LYS A N     1 ? 
ATOM   3532  C  CA    . LYS A 1 499 ? -2.921  29.067  -32.409  1    50.667  ? 499  LYS A CA    1 ? 
ATOM   3533  C  C     . LYS A 1 499 ? -3.644  28.281  -31.31   1    50.081  ? 499  LYS A C     1 ? 
ATOM   3534  O  O     . LYS A 1 499 ? -4.664  28.725  -30.782  1    45.041  ? 499  LYS A O     1 ? 
ATOM   3535  C  CB    . LYS A 1 499 ? -2.33   30.405  -31.936  1    53.221  ? 499  LYS A CB    1 ? 
ATOM   3536  C  CG    . LYS A 1 499 ? -1.533  31.161  -32.988  1    59.802  ? 499  LYS A CG    1 ? 
ATOM   3537  C  CD    . LYS A 1 499 ? -0.148  30.594  -33.282  1    68.158  ? 499  LYS A CD    1 ? 
ATOM   3538  C  CE    . LYS A 1 499 ? 0.84    31.022  -32.237  1    82.962  ? 499  LYS A CE    1 ? 
ATOM   3539  N  NZ    . LYS A 1 499 ? 2.201   30.593  -32.564  1    90.742  ? 499  LYS A NZ    1 ? 
ATOM   3540  N  N     . ILE A 1 500 ? -3.157  27.07   -31.034  1    46.205  ? 500  ILE A N     1 ? 
ATOM   3541  C  CA    . ILE A 1 500 ? -3.764  26.2    -30.036  1    43.496  ? 500  ILE A CA    1 ? 
ATOM   3542  C  C     . ILE A 1 500 ? -2.833  26.175  -28.827  1    41.726  ? 500  ILE A C     1 ? 
ATOM   3543  O  O     . ILE A 1 500 ? -1.668  25.807  -28.963  1    45.812  ? 500  ILE A O     1 ? 
ATOM   3544  C  CB    . ILE A 1 500 ? -3.97   24.789  -30.611  1    40.017  ? 500  ILE A CB    1 ? 
ATOM   3545  C  CG1   . ILE A 1 500 ? -4.913  24.785  -31.808  1    42.108  ? 500  ILE A CG1   1 ? 
ATOM   3546  C  CG2   . ILE A 1 500 ? -4.477  23.835  -29.523  1    43.23   ? 500  ILE A CG2   1 ? 
ATOM   3547  C  CD1   . ILE A 1 500 ? -5.119  23.398  -32.395  1    38.136  ? 500  ILE A CD1   1 ? 
ATOM   3548  N  N     . HIS A 1 501 ? -3.347  26.605  -27.672  1    42.327  ? 501  HIS A N     1 ? 
ATOM   3549  C  CA    . HIS A 1 501 ? -2.568  26.717  -26.445  1    47.638  ? 501  HIS A CA    1 ? 
ATOM   3550  C  C     . HIS A 1 501 ? -3.253  25.929  -25.313  1    41.415  ? 501  HIS A C     1 ? 
ATOM   3551  O  O     . HIS A 1 501 ? -4.435  26.147  -25.02   1    47.298  ? 501  HIS A O     1 ? 
ATOM   3552  C  CB    . HIS A 1 501 ? -2.306  28.202  -26.129  1    57.05   ? 501  HIS A CB    1 ? 
ATOM   3553  C  CG    . HIS A 1 501 ? -1.726  28.451  -24.765  1    85.066  ? 501  HIS A CG    1 ? 
ATOM   3554  N  ND1   . HIS A 1 501 ? -0.38   28.336  -24.471  1    95.873  ? 501  HIS A ND1   1 ? 
ATOM   3555  C  CD2   . HIS A 1 501 ? -2.326  28.774  -23.599  1    88.454  ? 501  HIS A CD2   1 ? 
ATOM   3556  C  CE1   . HIS A 1 501 ? -0.181  28.594  -23.181  1    92.503  ? 501  HIS A CE1   1 ? 
ATOM   3557  N  NE2   . HIS A 1 501 ? -1.351  28.866  -22.632  1    89.597  ? 501  HIS A NE2   1 ? 
ATOM   3558  N  N     . PHE A 1 502 ? -2.518  25.014  -24.668  1    34.798  ? 502  PHE A N     1 ? 
ATOM   3559  C  CA    . PHE A 1 502 ? -3.051  24.316  -23.495  1    35.103  ? 502  PHE A CA    1 ? 
ATOM   3560  C  C     . PHE A 1 502 ? -2.212  24.599  -22.256  1    35.806  ? 502  PHE A C     1 ? 
ATOM   3561  O  O     . PHE A 1 502 ? -0.989  24.64   -22.359  1    42.128  ? 502  PHE A O     1 ? 
ATOM   3562  C  CB    . PHE A 1 502 ? -3.025  22.799  -23.701  1    28.106  ? 502  PHE A CB    1 ? 
ATOM   3563  C  CG    . PHE A 1 502 ? -4.015  22.343  -24.758  1    27.639  ? 502  PHE A CG    1 ? 
ATOM   3564  C  CD1   . PHE A 1 502 ? -5.386  22.408  -24.515  1    26.642  ? 502  PHE A CD1   1 ? 
ATOM   3565  C  CD2   . PHE A 1 502 ? -3.576  21.87   -25.989  1    26.756  ? 502  PHE A CD2   1 ? 
ATOM   3566  C  CE1   . PHE A 1 502 ? -6.306  21.988  -25.448  1    23.913  ? 502  PHE A CE1   1 ? 
ATOM   3567  C  CE2   . PHE A 1 502 ? -4.504  21.442  -26.927  1    28.682  ? 502  PHE A CE2   1 ? 
ATOM   3568  C  CZ    . PHE A 1 502 ? -5.859  21.498  -26.661  1    25.241  ? 502  PHE A CZ    1 ? 
ATOM   3569  N  N     . GLU A 1 503 ? -2.868  24.711  -21.088  1    30.651  ? 503  GLU A N     1 ? 
ATOM   3570  C  CA    . GLU A 1 503 ? -2.175  24.728  -19.801  1    32.18   ? 503  GLU A CA    1 ? 
ATOM   3571  C  C     . GLU A 1 503 ? -2.362  23.403  -19.055  1    29.774  ? 503  GLU A C     1 ? 
ATOM   3572  O  O     . GLU A 1 503 ? -3.487  22.938  -18.877  1    27.205  ? 503  GLU A O     1 ? 
ATOM   3573  C  CB    . GLU A 1 503 ? -2.719  25.872  -18.935  1    36.525  ? 503  GLU A CB    1 ? 
ATOM   3574  C  CG    . GLU A 1 503 ? -2.154  27.236  -19.306  1    53.018  ? 503  GLU A CG    1 ? 
ATOM   3575  C  CD    . GLU A 1 503 ? -0.652  27.262  -19.051  1    68.065  ? 503  GLU A CD    1 ? 
ATOM   3576  O  OE1   . GLU A 1 503 ? -0.154  26.419  -18.26   1    70.499  ? 503  GLU A OE1   1 ? 
ATOM   3577  O  OE2   . GLU A 1 503 ? 0.032   28.106  -19.676  1    78.768  ? 503  GLU A OE2   1 ? 
ATOM   3578  N  N     . LEU A 1 504 ? -1.273  22.849  -18.506  1    25.295  ? 504  LEU A N     1 ? 
ATOM   3579  C  CA    . LEU A 1 504 ? -1.379  21.528  -17.932  1    26.41   ? 504  LEU A CA    1 ? 
ATOM   3580  C  C     . LEU A 1 504 ? -2.389  21.489  -16.782  1    25.301  ? 504  LEU A C     1 ? 
ATOM   3581  O  O     . LEU A 1 504 ? -3.222  20.583  -16.754  1    24.266  ? 504  LEU A O     1 ? 
ATOM   3582  C  CB    . LEU A 1 504 ? -0.026  20.994  -17.511  1    25.693  ? 504  LEU A CB    1 ? 
ATOM   3583  C  CG    . LEU A 1 504 ? -0.039  19.626  -16.841  1    26.216  ? 504  LEU A CG    1 ? 
ATOM   3584  C  CD1   . LEU A 1 504 ? -0.64   18.606  -17.757  1    23.797  ? 504  LEU A CD1   1 ? 
ATOM   3585  C  CD2   . LEU A 1 504 ? 1.37    19.194  -16.446  1    29.8    ? 504  LEU A CD2   1 ? 
ATOM   3586  N  N     . GLY A 1 505 ? -2.306  22.464  -15.859  1    24.506  ? 505  GLY A N     1 ? 
ATOM   3587  C  CA    . GLY A 1 505 ? -3.113  22.472  -14.643  1    22.767  ? 505  GLY A CA    1 ? 
ATOM   3588  C  C     . GLY A 1 505 ? -2.889  21.206  -13.82   1    24.505  ? 505  GLY A C     1 ? 
ATOM   3589  O  O     . GLY A 1 505 ? -1.813  20.616  -13.852  1    25.998  ? 505  GLY A O     1 ? 
ATOM   3590  N  N     . LYS A 1 506 ? -3.907  20.786  -13.058  1    24.391  ? 506  LYS A N     1 ? 
ATOM   3591  C  CA    . LYS A 1 506 ? -3.79   19.626  -12.191  1    20.437  ? 506  LYS A CA    1 ? 
ATOM   3592  C  C     . LYS A 1 506 ? -5.159  18.975  -11.968  1    19.088  ? 506  LYS A C     1 ? 
ATOM   3593  O  O     . LYS A 1 506 ? -6.214  19.64   -12.048  1    16.394  ? 506  LYS A O     1 ? 
ATOM   3594  C  CB    . LYS A 1 506 ? -3.147  20.061  -10.869  1    21.284  ? 506  LYS A CB    1 ? 
ATOM   3595  C  CG    . LYS A 1 506 ? -3.941  21.08   -10.064  1    27.975  ? 506  LYS A CG    1 ? 
ATOM   3596  C  CD    . LYS A 1 506 ? -3.1    21.527  -8.872   1    38.975  ? 506  LYS A CD    1 ? 
ATOM   3597  C  CE    . LYS A 1 506 ? -3.908  21.891  -7.694   1    40.715  ? 506  LYS A CE    1 ? 
ATOM   3598  N  NZ    . LYS A 1 506 ? -4.064  23.339  -7.554   1    47.994  ? 506  LYS A NZ    1 ? 
ATOM   3599  N  N     . PRO A 1 507 ? -5.152  17.669  -11.607  1    19.016  ? 507  PRO A N     1 ? 
ATOM   3600  C  CA    . PRO A 1 507 ? -6.387  16.916  -11.372  1    18.488  ? 507  PRO A CA    1 ? 
ATOM   3601  C  C     . PRO A 1 507 ? -7.118  17.51   -10.181  1    18.04   ? 507  PRO A C     1 ? 
ATOM   3602  O  O     . PRO A 1 507 ? -6.494  18.004  -9.244   1    21.308  ? 507  PRO A O     1 ? 
ATOM   3603  C  CB    . PRO A 1 507 ? -5.945  15.475  -11.037  1    18.973  ? 507  PRO A CB    1 ? 
ATOM   3604  C  CG    . PRO A 1 507 ? -4.413  15.492  -10.88   1    20.134  ? 507  PRO A CG    1 ? 
ATOM   3605  C  CD    . PRO A 1 507 ? -3.928  16.843  -11.434  1    19.538  ? 507  PRO A CD    1 ? 
ATOM   3606  N  N     . PHE A 1 508 ? -8.451  17.491  -10.229  1    19.018  ? 508  PHE A N     1 ? 
ATOM   3607  C  CA    . PHE A 1 508 ? -9.219  17.829  -9.032   1    18.512  ? 508  PHE A CA    1 ? 
ATOM   3608  C  C     . PHE A 1 508 ? -8.932  16.848  -7.888   1    17.102  ? 508  PHE A C     1 ? 
ATOM   3609  O  O     . PHE A 1 508 ? -8.633  15.661  -8.089   1    16.899  ? 508  PHE A O     1 ? 
ATOM   3610  C  CB    . PHE A 1 508 ? -10.71  17.652  -9.347   1    16.571  ? 508  PHE A CB    1 ? 
ATOM   3611  C  CG    . PHE A 1 508 ? -11.464 18.793  -10.023  1    16.977  ? 508  PHE A CG    1 ? 
ATOM   3612  C  CD1   . PHE A 1 508 ? -10.878 20.022  -10.276  1    17.443  ? 508  PHE A CD1   1 ? 
ATOM   3613  C  CD2   . PHE A 1 508 ? -12.806 18.616  -10.378  1    18.368  ? 508  PHE A CD2   1 ? 
ATOM   3614  C  CE1   . PHE A 1 508 ? -11.602 21.071  -10.857  1    19.645  ? 508  PHE A CE1   1 ? 
ATOM   3615  C  CE2   . PHE A 1 508 ? -13.53  19.653  -10.961  1    17.797  ? 508  PHE A CE2   1 ? 
ATOM   3616  C  CZ    . PHE A 1 508 ? -12.926 20.881  -11.212  1    20.509  ? 508  PHE A CZ    1 ? 
ATOM   3617  N  N     . LYS A 1 509 ? -9.147  17.31   -6.664   1    16.598  ? 509  LYS A N     1 ? 
ATOM   3618  C  CA    . LYS A 1 509 ? -9.27   16.388  -5.554   1    16.381  ? 509  LYS A CA    1 ? 
ATOM   3619  C  C     . LYS A 1 509 ? -10.573 15.615  -5.725   1    16.985  ? 509  LYS A C     1 ? 
ATOM   3620  O  O     . LYS A 1 509 ? -11.49  16.099  -6.349   1    16.842  ? 509  LYS A O     1 ? 
ATOM   3621  C  CB    . LYS A 1 509 ? -9.328  17.181  -4.237   1    21.575  ? 509  LYS A CB    1 ? 
ATOM   3622  C  CG    . LYS A 1 509 ? -8.064  18.046  -3.917   1    25.079  ? 509  LYS A CG    1 ? 
ATOM   3623  C  CD    . LYS A 1 509 ? -8.166  18.713  -2.54    1    34.093  ? 509  LYS A CD    1 ? 
ATOM   3624  C  CE    . LYS A 1 509 ? -6.956  19.274  -1.807   1    33.499  ? 509  LYS A CE    1 ? 
ATOM   3625  N  NZ    . LYS A 1 509 ? -6.427  20.375  -2.607   1    41.283  ? 509  LYS A NZ    1 ? 
ATOM   3626  N  N     . PRO A 1 510 ? -10.674 14.375  -5.221   1    17.787  ? 510  PRO A N     1 ? 
ATOM   3627  C  CA    . PRO A 1 510 ? -11.83  13.54   -5.512   1    17.288  ? 510  PRO A CA    1 ? 
ATOM   3628  C  C     . PRO A 1 510 ? -13.189 14.128  -5.117   1    16.86   ? 510  PRO A C     1 ? 
ATOM   3629  O  O     . PRO A 1 510 ? -14.119 13.982  -5.891   1    17.841  ? 510  PRO A O     1 ? 
ATOM   3630  C  CB    . PRO A 1 510 ? -11.473 12.211  -4.812   1    17.517  ? 510  PRO A CB    1 ? 
ATOM   3631  C  CG    . PRO A 1 510 ? -10.458 12.616  -3.742   1    17.449  ? 510  PRO A CG    1 ? 
ATOM   3632  C  CD    . PRO A 1 510 ? -9.662  13.716  -4.371   1    17.377  ? 510  PRO A CD    1 ? 
ATOM   3633  N  N     . PHE A 1 511 ? -13.28  14.869  -3.996   1    18.302  ? 511  PHE A N     1 ? 
ATOM   3634  C  CA    . PHE A 1 511 ? -14.55  15.485  -3.593   1    17.138  ? 511  PHE A CA    1 ? 
ATOM   3635  C  C     . PHE A 1 511 ? -14.968 16.586  -4.569   1    17.97   ? 511  PHE A C     1 ? 
ATOM   3636  O  O     . PHE A 1 511 ? -16.171 16.823  -4.75    1    21.472  ? 511  PHE A O     1 ? 
ATOM   3637  C  CB    . PHE A 1 511 ? -14.491 16.008  -2.155   1    16.436  ? 511  PHE A CB    1 ? 
ATOM   3638  C  CG    . PHE A 1 511 ? -14.406 14.887  -1.114   1    18.686  ? 511  PHE A CG    1 ? 
ATOM   3639  C  CD1   . PHE A 1 511 ? -14.711 13.576  -1.435   1    19.249  ? 511  PHE A CD1   1 ? 
ATOM   3640  C  CD2   . PHE A 1 511 ? -14.098 15.168  0.208    1    16.641  ? 511  PHE A CD2   1 ? 
ATOM   3641  C  CE1   . PHE A 1 511 ? -14.692 12.592  -0.451   1    21.088  ? 511  PHE A CE1   1 ? 
ATOM   3642  C  CE2   . PHE A 1 511 ? -14.083 14.187  1.179    1    16.872  ? 511  PHE A CE2   1 ? 
ATOM   3643  C  CZ    . PHE A 1 511 ? -14.313 12.891  0.828    1    20.554  ? 511  PHE A CZ    1 ? 
ATOM   3644  N  N     . GLU A 1 512 ? -13.996 17.259  -5.199   1    16.288  ? 512  GLU A N     1 ? 
ATOM   3645  C  CA    . GLU A 1 512 ? -14.259 18.275  -6.217   1    18.732  ? 512  GLU A CA    1 ? 
ATOM   3646  C  C     . GLU A 1 512 ? -14.844 17.609  -7.472   1    18.982  ? 512  GLU A C     1 ? 
ATOM   3647  O  O     . GLU A 1 512 ? -15.854 18.038  -8.023   1    18.525  ? 512  GLU A O     1 ? 
ATOM   3648  C  CB    . GLU A 1 512 ? -12.979 19.091  -6.512   1    18.806  ? 512  GLU A CB    1 ? 
ATOM   3649  C  CG    . GLU A 1 512 ? -12.455 19.835  -5.279   1    17.408  ? 512  GLU A CG    1 ? 
ATOM   3650  C  CD    . GLU A 1 512 ? -10.997 20.3    -5.365   1    19.097  ? 512  GLU A CD    1 ? 
ATOM   3651  O  OE1   . GLU A 1 512 ? -10.32  20.049  -6.378   1    17.913  ? 512  GLU A OE1   1 ? 
ATOM   3652  O  OE2   . GLU A 1 512 ? -10.564 20.925  -4.385   1    21.656  ? 512  GLU A OE2   1 ? 
ATOM   3653  N  N     . GLN A 1 513 ? -14.243 16.519  -7.924   1    16.746  ? 513  GLN A N     1 ? 
ATOM   3654  C  CA    . GLN A 1 513 ? -14.927 15.789  -8.982   1    17.459  ? 513  GLN A CA    1 ? 
ATOM   3655  C  C     . GLN A 1 513 ? -16.275 15.232  -8.513   1    17.316  ? 513  GLN A C     1 ? 
ATOM   3656  O  O     . GLN A 1 513 ? -17.228 15.159  -9.29    1    16.318  ? 513  GLN A O     1 ? 
ATOM   3657  C  CB    . GLN A 1 513 ? -14.087 14.595  -9.442   1    18.036  ? 513  GLN A CB    1 ? 
ATOM   3658  C  CG    . GLN A 1 513 ? -14.776 13.847  -10.577  1    21.819  ? 513  GLN A CG    1 ? 
ATOM   3659  C  CD    . GLN A 1 513 ? -13.923 12.85   -11.327  1    25.521  ? 513  GLN A CD    1 ? 
ATOM   3660  O  OE1   . GLN A 1 513 ? -13.104 13.196  -12.187  1    24.896  ? 513  GLN A OE1   1 ? 
ATOM   3661  N  NE2   . GLN A 1 513 ? -14.183 11.586  -11.07   1    28.343  ? 513  GLN A NE2   1 ? 
ATOM   3662  N  N     . LEU A 1 514 ? -16.334 14.751  -7.26    1    17.198  ? 514  LEU A N     1 ? 
ATOM   3663  C  CA    . LEU A 1 514 ? -17.531 14.036  -6.824   1    20.197  ? 514  LEU A CA    1 ? 
ATOM   3664  C  C     . LEU A 1 514 ? -18.706 15.041  -6.795   1    20.995  ? 514  LEU A C     1 ? 
ATOM   3665  O  O     . LEU A 1 514 ? -19.795 14.789  -7.319   1    19.311  ? 514  LEU A O     1 ? 
ATOM   3666  C  CB    . LEU A 1 514 ? -17.304 13.352  -5.47    1    19.426  ? 514  LEU A CB    1 ? 
ATOM   3667  C  CG    . LEU A 1 514 ? -18.455 12.466  -4.955   1    19.152  ? 514  LEU A CG    1 ? 
ATOM   3668  C  CD1   . LEU A 1 514 ? -18.74  11.308  -5.927   1    15.167  ? 514  LEU A CD1   1 ? 
ATOM   3669  C  CD2   . LEU A 1 514 ? -18.07  11.914  -3.592   1    19.693  ? 514  LEU A CD2   1 ? 
ATOM   3670  N  N     . LEU A 1 515 ? -18.482 16.211  -6.199   1    18.845  ? 515  LEU A N     1 ? 
ATOM   3671  C  CA    . LEU A 1 515 ? -19.499 17.261  -6.224   1    19.027  ? 515  LEU A CA    1 ? 
ATOM   3672  C  C     . LEU A 1 515 ? -19.912 17.627  -7.657   1    20.277  ? 515  LEU A C     1 ? 
ATOM   3673  O  O     . LEU A 1 515 ? -21.103 17.827  -7.951   1    20.891  ? 515  LEU A O     1 ? 
ATOM   3674  C  CB    . LEU A 1 515 ? -19.046 18.491  -5.444   1    16.896  ? 515  LEU A CB    1 ? 
ATOM   3675  C  CG    . LEU A 1 515 ? -20.073 19.624  -5.341   1    22.103  ? 515  LEU A CG    1 ? 
ATOM   3676  C  CD1   . LEU A 1 515 ? -21.409 19.117  -4.764   1    17.296  ? 515  LEU A CD1   1 ? 
ATOM   3677  C  CD2   . LEU A 1 515 ? -19.467 20.681  -4.449   1    20.986  ? 515  LEU A CD2   1 ? 
ATOM   3678  N  N     . ALA A 1 516 ? -18.918 17.776  -8.541   1    18.115  ? 516  ALA A N     1 ? 
ATOM   3679  C  CA    . ALA A 1 516 ? -19.205 18.154  -9.904   1    18.403  ? 516  ALA A CA    1 ? 
ATOM   3680  C  C     . ALA A 1 516 ? -20.116 17.151  -10.609  1    18.423  ? 516  ALA A C     1 ? 
ATOM   3681  O  O     . ALA A 1 516 ? -21.033 17.584  -11.333  1    21.056  ? 516  ALA A O     1 ? 
ATOM   3682  C  CB    . ALA A 1 516 ? -17.934 18.408  -10.701  1    16.662  ? 516  ALA A CB    1 ? 
ATOM   3683  N  N     . VAL A 1 517 ? -19.865 15.85   -10.411  1    16.263  ? 517  VAL A N     1 ? 
ATOM   3684  C  CA    . VAL A 1 517 ? -20.421 14.88   -11.346  1    17.954  ? 517  VAL A CA    1 ? 
ATOM   3685  C  C     . VAL A 1 517 ? -21.746 14.282  -10.852  1    16.922  ? 517  VAL A C     1 ? 
ATOM   3686  O  O     . VAL A 1 517 ? -22.45  13.636  -11.626  1    16.311  ? 517  VAL A O     1 ? 
ATOM   3687  C  CB    . VAL A 1 517 ? -19.435 13.79   -11.825  1    17.991  ? 517  VAL A CB    1 ? 
ATOM   3688  C  CG1   . VAL A 1 517 ? -18.232 14.386  -12.589  1    16.393  ? 517  VAL A CG1   1 ? 
ATOM   3689  C  CG2   . VAL A 1 517 ? -18.988 12.861  -10.705  1    18.935  ? 517  VAL A CG2   1 ? 
ATOM   3690  N  N     . LEU A 1 518 ? -22.122 14.511  -9.581   1    16.135  ? 518  LEU A N     1 ? 
ATOM   3691  C  CA    . LEU A 1 518 ? -23.283 13.798  -9.062   1    16.752  ? 518  LEU A CA    1 ? 
ATOM   3692  C  C     . LEU A 1 518 ? -24.546 14.654  -9.232   1    16.475  ? 518  LEU A C     1 ? 
ATOM   3693  O  O     . LEU A 1 518 ? -24.487 15.85   -9.035   1    15.502  ? 518  LEU A O     1 ? 
ATOM   3694  C  CB    . LEU A 1 518 ? -23.136 13.446  -7.576   1    15.044  ? 518  LEU A CB    1 ? 
ATOM   3695  C  CG    . LEU A 1 518 ? -22.178 12.305  -7.212   1    16.556  ? 518  LEU A CG    1 ? 
ATOM   3696  C  CD1   . LEU A 1 518 ? -22.099 12.241  -5.681   1    15.94   ? 518  LEU A CD1   1 ? 
ATOM   3697  C  CD2   . LEU A 1 518 ? -22.687 11.007  -7.845   1    17.339  ? 518  LEU A CD2   1 ? 
ATOM   3698  N  N     . PRO A 1 519 ? -25.75  14.066  -9.425   1    15.565  ? 519  PRO A N     1 ? 
ATOM   3699  C  CA    . PRO A 1 519 ? -26.989 14.822  -9.181   1    17.554  ? 519  PRO A CA    1 ? 
ATOM   3700  C  C     . PRO A 1 519 ? -27.345 14.938  -7.687   1    19.334  ? 519  PRO A C     1 ? 
ATOM   3701  O  O     . PRO A 1 519 ? -26.899 14.155  -6.834   1    17.372  ? 519  PRO A O     1 ? 
ATOM   3702  C  CB    . PRO A 1 519 ? -28.001 13.944  -9.972   1    17.022  ? 519  PRO A CB    1 ? 
ATOM   3703  C  CG    . PRO A 1 519 ? -27.504 12.492  -9.727   1    15.474  ? 519  PRO A CG    1 ? 
ATOM   3704  C  CD    . PRO A 1 519 ? -25.958 12.67   -9.842   1    15.33   ? 519  PRO A CD    1 ? 
ATOM   3705  N  N     . ALA A 1 520 ? -28.223 15.895  -7.353   1    20.282  ? 520  ALA A N     1 ? 
ATOM   3706  C  CA    . ALA A 1 520 ? -28.736 16.034  -5.993   1    17.851  ? 520  ALA A CA    1 ? 
ATOM   3707  C  C     . ALA A 1 520 ? -29.348 14.727  -5.484   1    17.488  ? 520  ALA A C     1 ? 
ATOM   3708  O  O     . ALA A 1 520 ? -29.3   14.467  -4.282   1    15.876  ? 520  ALA A O     1 ? 
ATOM   3709  C  CB    . ALA A 1 520 ? -29.742 17.165  -5.883   1    15.739  ? 520  ALA A CB    1 ? 
ATOM   3710  N  N     . ALA A 1 521 ? -29.887 13.881  -6.357   1    16.534  ? 521  ALA A N     1 ? 
ATOM   3711  C  CA    . ALA A 1 521 ? -30.487 12.666  -5.786   1    21.196  ? 521  ALA A CA    1 ? 
ATOM   3712  C  C     . ALA A 1 521 ? -29.422 11.731  -5.209   1    20.538  ? 521  ALA A C     1 ? 
ATOM   3713  O  O     . ALA A 1 521 ? -29.738 10.888  -4.371   1    17.126  ? 521  ALA A O     1 ? 
ATOM   3714  C  CB    . ALA A 1 521 ? -31.324 11.896  -6.79    1    19.427  ? 521  ALA A CB    1 ? 
ATOM   3715  N  N     . SER A 1 522 ? -28.143 11.919  -5.592   1    19.262  ? 522  SER A N     1 ? 
ATOM   3716  C  CA    . SER A 1 522 ? -27.103 11.079  -5.018   1    16.608  ? 522  SER A CA    1 ? 
ATOM   3717  C  C     . SER A 1 522 ? -26.279 11.826  -3.98    1    20.329  ? 522  SER A C     1 ? 
ATOM   3718  O  O     . SER A 1 522 ? -25.095 11.504  -3.801   1    17.076  ? 522  SER A O     1 ? 
ATOM   3719  C  CB    . SER A 1 522 ? -26.149 10.696  -6.132   1    15.782  ? 522  SER A CB    1 ? 
ATOM   3720  O  OG    . SER A 1 522 ? -26.722 9.755   -7.014   1    14.585  ? 522  SER A OG    1 ? 
ATOM   3721  N  N     . LYS A 1 523 ? -26.829 12.894  -3.393   1    19.238  ? 523  LYS A N     1 ? 
ATOM   3722  C  CA    . LYS A 1 523 ? -25.993 13.768  -2.587   1    21.714  ? 523  LYS A CA    1 ? 
ATOM   3723  C  C     . LYS A 1 523 ? -25.445 13.078  -1.332   1    22.428  ? 523  LYS A C     1 ? 
ATOM   3724  O  O     . LYS A 1 523 ? -24.43  13.511  -0.779   1    22.097  ? 523  LYS A O     1 ? 
ATOM   3725  C  CB    . LYS A 1 523 ? -26.791 15.019  -2.202   1    21.42   ? 523  LYS A CB    1 ? 
ATOM   3726  C  CG    . LYS A 1 523 ? -27.903 14.721  -1.212   1    24.776  ? 523  LYS A CG    1 ? 
ATOM   3727  C  CD    . LYS A 1 523 ? -28.873 15.877  -1.062   1    29.633  ? 523  LYS A CD    1 ? 
ATOM   3728  C  CE    . LYS A 1 523 ? -29.959 15.385  -0.139   1    37.368  ? 523  LYS A CE    1 ? 
ATOM   3729  N  NZ    . LYS A 1 523 ? -29.894 16.114  1.123    1    39.505  ? 523  LYS A NZ    1 ? 
ATOM   3730  N  N     . ASN A 1 524 ? -26.112 12.018  -0.864   1    21.321  ? 524  ASN A N     1 ? 
ATOM   3731  C  CA    . ASN A 1 524 ? -25.69  11.302  0.331    1    22.334  ? 524  ASN A CA    1 ? 
ATOM   3732  C  C     . ASN A 1 524 ? -24.331 10.608  0.139    1    19.703  ? 524  ASN A C     1 ? 
ATOM   3733  O  O     . ASN A 1 524 ? -23.731 10.199  1.107    1    19.821  ? 524  ASN A O     1 ? 
ATOM   3734  C  CB    . ASN A 1 524 ? -26.78  10.422  0.947    1    29.431  ? 524  ASN A CB    1 ? 
ATOM   3735  C  CG    . ASN A 1 524 ? -27.089 9.188   0.14     1    43.284  ? 524  ASN A CG    1 ? 
ATOM   3736  O  OD1   . ASN A 1 524 ? -26.494 8.952   -0.923   1    52.046  ? 524  ASN A OD1   1 ? 
ATOM   3737  N  ND2   . ASN A 1 524 ? -28.056 8.4     0.601    1    47.92   ? 524  ASN A ND2   1 ? 
ATOM   3738  N  N     . LEU A 1 525 ? -23.8   10.573  -1.073   1    17.963  ? 525  LEU A N     1 ? 
ATOM   3739  C  CA    . LEU A 1 525 ? -22.481 10.014  -1.321   1    18.6    ? 525  LEU A CA    1 ? 
ATOM   3740  C  C     . LEU A 1 525 ? -21.405 11.029  -0.968   1    18.556  ? 525  LEU A C     1 ? 
ATOM   3741  O  O     . LEU A 1 525 ? -20.243 10.65   -0.927   1    21.022  ? 525  LEU A O     1 ? 
ATOM   3742  C  CB    . LEU A 1 525 ? -22.381 9.64    -2.805   1    16.708  ? 525  LEU A CB    1 ? 
ATOM   3743  C  CG    . LEU A 1 525 ? -23.385 8.581   -3.268   1    20.154  ? 525  LEU A CG    1 ? 
ATOM   3744  C  CD1   . LEU A 1 525 ? -23.245 8.258   -4.761   1    14.967  ? 525  LEU A CD1   1 ? 
ATOM   3745  C  CD2   . LEU A 1 525 ? -23.226 7.333   -2.38    1    18.804  ? 525  LEU A CD2   1 ? 
ATOM   3746  N  N     . LEU A 1 526 ? -21.783 12.314  -0.836   1    19.387  ? 526  LEU A N     1 ? 
ATOM   3747  C  CA    . LEU A 1 526 ? -20.878 13.401  -0.501   1    18.573  ? 526  LEU A CA    1 ? 
ATOM   3748  C  C     . LEU A 1 526 ? -20.845 13.659  1.001    1    20.368  ? 526  LEU A C     1 ? 
ATOM   3749  O  O     . LEU A 1 526 ? -21.864 13.484  1.654    1    19.527  ? 526  LEU A O     1 ? 
ATOM   3750  C  CB    . LEU A 1 526 ? -21.362 14.661  -1.216   1    19.885  ? 526  LEU A CB    1 ? 
ATOM   3751  C  CG    . LEU A 1 526 ? -20.887 14.762  -2.672   1    22.266  ? 526  LEU A CG    1 ? 
ATOM   3752  C  CD1   . LEU A 1 526 ? -21.769 15.772  -3.386   1    25.581  ? 526  LEU A CD1   1 ? 
ATOM   3753  C  CD2   . LEU A 1 526 ? -19.463 15.317  -2.625   1    17.206  ? 526  LEU A CD2   1 ? 
ATOM   3754  N  N     . PRO A 1 527 ? -19.709 14.174  1.557    1    17.769  ? 527  PRO A N     1 ? 
ATOM   3755  C  CA    . PRO A 1 527 ? -19.687 14.707  2.916    1    19.233  ? 527  PRO A CA    1 ? 
ATOM   3756  C  C     . PRO A 1 527 ? -20.852 15.683  3.109    1    20.171  ? 527  PRO A C     1 ? 
ATOM   3757  O  O     . PRO A 1 527 ? -21.21  16.407  2.185    1    18.905  ? 527  PRO A O     1 ? 
ATOM   3758  C  CB    . PRO A 1 527 ? -18.327 15.469  2.888    1    18.739  ? 527  PRO A CB    1 ? 
ATOM   3759  C  CG    . PRO A 1 527 ? -17.444 14.593  2.016    1    19.506  ? 527  PRO A CG    1 ? 
ATOM   3760  C  CD    . PRO A 1 527 ? -18.407 14.269  0.851    1    19.162  ? 527  PRO A CD    1 ? 
ATOM   3761  N  N     . ALA A 1 528 ? -21.477 15.667  4.288    1    22.103  ? 528  ALA A N     1 ? 
ATOM   3762  C  CA    . ALA A 1 528 ? -22.656 16.485  4.577    1    22.711  ? 528  ALA A CA    1 ? 
ATOM   3763  C  C     . ALA A 1 528 ? -22.362 17.963  4.313    1    23.411  ? 528  ALA A C     1 ? 
ATOM   3764  O  O     . ALA A 1 528 ? -23.23  18.706  3.883    1    18.997  ? 528  ALA A O     1 ? 
ATOM   3765  C  CB    . ALA A 1 528 ? -23.049 16.292  6.036    1    25.54   ? 528  ALA A CB    1 ? 
ATOM   3766  N  N     . CYS A 1 529 ? -21.115 18.382  4.56     1    21.819  ? 529  CYS A N     1 ? 
ATOM   3767  C  CA    . CYS A 1 529 ? -20.762 19.784  4.478    1    22.577  ? 529  CYS A CA    1 ? 
ATOM   3768  C  C     . CYS A 1 529 ? -20.899 20.381  3.071    1    19.51   ? 529  CYS A C     1 ? 
ATOM   3769  O  O     . CYS A 1 529 ? -21.005 21.587  2.96     1    22.57   ? 529  CYS A O     1 ? 
ATOM   3770  C  CB    . CYS A 1 529 ? -19.361 20.006  5.05     1    25.811  ? 529  CYS A CB    1 ? 
ATOM   3771  S  SG    . CYS A 1 529 ? -18.077 19.289  4.002    1    30.778  ? 529  CYS A SG    1 ? 
ATOM   3772  N  N     . TYR A 1 530 ? -20.883 19.592  1.986    1    16.336  ? 530  TYR A N     1 ? 
ATOM   3773  C  CA    . TYR A 1 530 ? -21.053 20.116  0.642    1    16.472  ? 530  TYR A CA    1 ? 
ATOM   3774  C  C     . TYR A 1 530 ? -22.48  19.956  0.11     1    18.109  ? 530  TYR A C     1 ? 
ATOM   3775  O  O     . TYR A 1 530 ? -22.784 20.49   -0.942   1    18.547  ? 530  TYR A O     1 ? 
ATOM   3776  C  CB    . TYR A 1 530 ? -20.256 19.267  -0.369   1    18.267  ? 530  TYR A CB    1 ? 
ATOM   3777  C  CG    . TYR A 1 530 ? -18.742 19.321  -0.165   1    19.341  ? 530  TYR A CG    1 ? 
ATOM   3778  C  CD1   . TYR A 1 530 ? -18.044 20.52   -0.125   1    20.553  ? 530  TYR A CD1   1 ? 
ATOM   3779  C  CD2   . TYR A 1 530 ? -18.027 18.152  0.021    1    20.774  ? 530  TYR A CD2   1 ? 
ATOM   3780  C  CE1   . TYR A 1 530 ? -16.665 20.543  0.076    1    23.308  ? 530  TYR A CE1   1 ? 
ATOM   3781  C  CE2   . TYR A 1 530 ? -16.659 18.15   0.223    1    19.397  ? 530  TYR A CE2   1 ? 
ATOM   3782  C  CZ    . TYR A 1 530 ? -15.982 19.344  0.256    1    22.44   ? 530  TYR A CZ    1 ? 
ATOM   3783  O  OH    . TYR A 1 530 ? -14.626 19.221  0.401    1    23.268  ? 530  TYR A OH    1 ? 
ATOM   3784  N  N     . GLN A 1 531 ? -23.33  19.165  0.77     1    18.178  ? 531  GLN A N     1 ? 
ATOM   3785  C  CA    . GLN A 1 531 ? -24.601 18.793  0.138    1    17.445  ? 531  GLN A CA    1 ? 
ATOM   3786  C  C     . GLN A 1 531 ? -25.472 20.023  -0.175   1    18.151  ? 531  GLN A C     1 ? 
ATOM   3787  O  O     . GLN A 1 531 ? -26.202 20.025  -1.166   1    18.77   ? 531  GLN A O     1 ? 
ATOM   3788  C  CB    . GLN A 1 531 ? -25.306 17.799  1.07     1    19.229  ? 531  GLN A CB    1 ? 
ATOM   3789  C  CG    . GLN A 1 531 ? -24.707 16.378  1.032    1    19.199  ? 531  GLN A CG    1 ? 
ATOM   3790  C  CD    . GLN A 1 531 ? -25.398 15.397  1.96     1    22.036  ? 531  GLN A CD    1 ? 
ATOM   3791  O  OE1   . GLN A 1 531 ? -26.584 15.525  2.271    1    25.941  ? 531  GLN A OE1   1 ? 
ATOM   3792  N  NE2   . GLN A 1 531 ? -24.68  14.379  2.412    1    20.85   ? 531  GLN A NE2   1 ? 
ATOM   3793  N  N     . HIS A 1 532 ? -25.516 21.027  0.718    1    17.115  ? 532  HIS A N     1 ? 
ATOM   3794  C  CA    . HIS A 1 532 ? -26.331 22.209  0.422    1    18.165  ? 532  HIS A CA    1 ? 
ATOM   3795  C  C     . HIS A 1 532 ? -25.961 22.874  -0.91    1    19.122  ? 532  HIS A C     1 ? 
ATOM   3796  O  O     . HIS A 1 532 ? -26.796 23.563  -1.494   1    19.615  ? 532  HIS A O     1 ? 
ATOM   3797  C  CB    . HIS A 1 532 ? -26.314 23.22   1.571    1    15.831  ? 532  HIS A CB    1 ? 
ATOM   3798  C  CG    . HIS A 1 532 ? -24.999 23.919  1.659    1    19.557  ? 532  HIS A CG    1 ? 
ATOM   3799  N  ND1   . HIS A 1 532 ? -24.005 23.509  2.522    1    20.049  ? 532  HIS A ND1   1 ? 
ATOM   3800  C  CD2   . HIS A 1 532 ? -24.555 25.032  1.066    1    16.556  ? 532  HIS A CD2   1 ? 
ATOM   3801  C  CE1   . HIS A 1 532 ? -22.957 24.307  2.367    1    23.54   ? 532  HIS A CE1   1 ? 
ATOM   3802  N  NE2   . HIS A 1 532 ? -23.284 25.26   1.52     1    19.837  ? 532  HIS A NE2   1 ? 
ATOM   3803  N  N     . LEU A 1 533 ? -24.732 22.658  -1.407   1    17.696  ? 533  LEU A N     1 ? 
ATOM   3804  C  CA    . LEU A 1 533 ? -24.341 23.334  -2.627   1    16.926  ? 533  LEU A CA    1 ? 
ATOM   3805  C  C     . LEU A 1 533 ? -25.149 22.804  -3.8     1    17.029  ? 533  LEU A C     1 ? 
ATOM   3806  O  O     . LEU A 1 533 ? -25.266 23.482  -4.827   1    17.209  ? 533  LEU A O     1 ? 
ATOM   3807  C  CB    . LEU A 1 533 ? -22.847 23.178  -2.875   1    16.833  ? 533  LEU A CB    1 ? 
ATOM   3808  C  CG    . LEU A 1 533 ? -21.926 23.923  -1.901   1    18.045  ? 533  LEU A CG    1 ? 
ATOM   3809  C  CD1   . LEU A 1 533 ? -20.454 23.576  -2.195   1    16.233  ? 533  LEU A CD1   1 ? 
ATOM   3810  C  CD2   . LEU A 1 533 ? -22.127 25.437  -2.009   1    19.355  ? 533  LEU A CD2   1 ? 
ATOM   3811  N  N     . MET A 1 534 ? -25.688 21.585  -3.652   1    16.269  ? 534  MET A N     1 ? 
ATOM   3812  C  CA    . MET A 1 534 ? -26.341 20.98   -4.792   1    16.824  ? 534  MET A CA    1 ? 
ATOM   3813  C  C     . MET A 1 534 ? -27.862 21.025  -4.616   1    15.606  ? 534  MET A C     1 ? 
ATOM   3814  O  O     . MET A 1 534 ? -28.559 20.613  -5.545   1    17.1    ? 534  MET A O     1 ? 
ATOM   3815  C  CB    . MET A 1 534 ? -26.037 19.475  -4.961   1    17.852  ? 534  MET A CB    1 ? 
ATOM   3816  C  CG    . MET A 1 534 ? -24.745 18.903  -4.372   1    24.641  ? 534  MET A CG    1 ? 
ATOM   3817  S  SD    . MET A 1 534 ? -24.858 17.092  -4.363   1    27.131  ? 534  MET A SD    1 ? 
ATOM   3818  C  CE    . MET A 1 534 ? -24.694 16.593  -6.075   1    20.401  ? 534  MET A CE    1 ? 
ATOM   3819  N  N     . THR A 1 535 ? -28.35  21.447  -3.45    1    17.637  ? 535  THR A N     1 ? 
ATOM   3820  C  CA    . THR A 1 535 ? -29.786 21.493  -3.16    1    20.636  ? 535  THR A CA    1 ? 
ATOM   3821  C  C     . THR A 1 535 ? -30.306 22.897  -2.861   1    21.797  ? 535  THR A C     1 ? 
ATOM   3822  O  O     . THR A 1 535 ? -31.471 23.166  -3.142   1    19.638  ? 535  THR A O     1 ? 
ATOM   3823  C  CB    . THR A 1 535 ? -30.151 20.548  -2.012   1    24.715  ? 535  THR A CB    1 ? 
ATOM   3824  O  OG1   . THR A 1 535 ? -29.416 20.881  -0.847   1    23.434  ? 535  THR A OG1   1 ? 
ATOM   3825  C  CG2   . THR A 1 535 ? -29.74  19.111  -2.275   1    20.791  ? 535  THR A CG2   1 ? 
ATOM   3826  N  N     . ASN A 1 536 ? -29.48  23.785  -2.27    1    20.436  ? 536  ASN A N     1 ? 
ATOM   3827  C  CA    . ASN A 1 536 ? -30.013 25.023  -1.709   1    18.498  ? 536  ASN A CA    1 ? 
ATOM   3828  C  C     . ASN A 1 536 ? -30.324 25.976  -2.852   1    21.547  ? 536  ASN A C     1 ? 
ATOM   3829  O  O     . ASN A 1 536 ? -29.47  26.2    -3.707   1    17.925  ? 536  ASN A O     1 ? 
ATOM   3830  C  CB    . ASN A 1 536 ? -29.053 25.696  -0.711   1    15.8    ? 536  ASN A CB    1 ? 
ATOM   3831  C  CG    . ASN A 1 536 ? -29.692 26.772  0.13     1    15.434  ? 536  ASN A CG    1 ? 
ATOM   3832  O  OD1   . ASN A 1 536 ? -30.068 27.815  -0.394   1    18.384  ? 536  ASN A OD1   1 ? 
ATOM   3833  N  ND2   . ASN A 1 536 ? -29.795 26.592  1.435    1    14.276  ? 536  ASN A ND2   1 ? 
ATOM   3834  N  N     . GLU A 1 537 ? -31.529 26.584  -2.822   1    21.37   ? 537  GLU A N     1 ? 
ATOM   3835  C  CA    . GLU A 1 537 ? -31.929 27.549  -3.838   1    21.945  ? 537  GLU A CA    1 ? 
ATOM   3836  C  C     . GLU A 1 537 ? -30.948 28.716  -3.947   1    18.907  ? 537  GLU A C     1 ? 
ATOM   3837  O  O     . GLU A 1 537 ? -30.871 29.35   -4.994   1    17.447  ? 537  GLU A O     1 ? 
ATOM   3838  C  CB    . GLU A 1 537 ? -33.202 28.345  -3.475   1    29.308  ? 537  GLU A CB    1 ? 
ATOM   3839  C  CG    . GLU A 1 537 ? -34.501 27.643  -3.836   1    42.633  ? 537  GLU A CG    1 ? 
ATOM   3840  C  CD    . GLU A 1 537 ? -35.615 28.677  -3.716   1    53.184  ? 537  GLU A CD    1 ? 
ATOM   3841  O  OE1   . GLU A 1 537 ? -35.785 29.291  -2.637   1    59.218  ? 537  GLU A OE1   1 ? 
ATOM   3842  O  OE2   . GLU A 1 537 ? -36.299 28.891  -4.732   1    61.415  ? 537  GLU A OE2   1 ? 
ATOM   3843  N  N     . ASP A 1 538 ? -30.279 29.077  -2.851   1    19.631  ? 538  ASP A N     1 ? 
ATOM   3844  C  CA    . ASP A 1 538 ? -29.315 30.17   -2.943   1    19.566  ? 538  ASP A CA    1 ? 
ATOM   3845  C  C     . ASP A 1 538 ? -27.891 29.645  -3.047   1    20.366  ? 538  ASP A C     1 ? 
ATOM   3846  O  O     . ASP A 1 538 ? -26.94  30.409  -2.939   1    22.099  ? 538  ASP A O     1 ? 
ATOM   3847  C  CB    . ASP A 1 538 ? -29.45  31.134  -1.776   1    24.144  ? 538  ASP A CB    1 ? 
ATOM   3848  C  CG    . ASP A 1 538 ? -30.805 31.837  -1.819   1    29.717  ? 538  ASP A CG    1 ? 
ATOM   3849  O  OD1   . ASP A 1 538 ? -31.088 32.455  -2.862   1    31.111  ? 538  ASP A OD1   1 ? 
ATOM   3850  O  OD2   . ASP A 1 538 ? -31.626 31.612  -0.911   1    28.789  ? 538  ASP A OD2   1 ? 
ATOM   3851  N  N     . SER A 1 539 ? -27.724 28.37   -3.35    1    20.057  ? 539  SER A N     1 ? 
ATOM   3852  C  CA    . SER A 1 539 ? -26.346 27.924  -3.564   1    19.443  ? 539  SER A CA    1 ? 
ATOM   3853  C  C     . SER A 1 539 ? -25.795 28.641  -4.795   1    19.328  ? 539  SER A C     1 ? 
ATOM   3854  O  O     . SER A 1 539 ? -26.494 28.75   -5.774   1    16.825  ? 539  SER A O     1 ? 
ATOM   3855  C  CB    . SER A 1 539 ? -26.287 26.444  -3.789   1    18.778  ? 539  SER A CB    1 ? 
ATOM   3856  O  OG    . SER A 1 539 ? -25.052 26.138  -4.439   1    19.112  ? 539  SER A OG    1 ? 
ATOM   3857  N  N     . PRO A 1 540 ? -24.529 29.143  -4.797   1    20.885  ? 540  PRO A N     1 ? 
ATOM   3858  C  CA    . PRO A 1 540 ? -23.963 29.821  -5.975   1    19.655  ? 540  PRO A CA    1 ? 
ATOM   3859  C  C     . PRO A 1 540 ? -23.839 28.955  -7.226   1    20.29   ? 540  PRO A C     1 ? 
ATOM   3860  O  O     . PRO A 1 540 ? -23.635 29.475  -8.309   1    23.311  ? 540  PRO A O     1 ? 
ATOM   3861  C  CB    . PRO A 1 540 ? -22.583 30.323  -5.542   1    25.661  ? 540  PRO A CB    1 ? 
ATOM   3862  C  CG    . PRO A 1 540 ? -22.321 29.684  -4.205   1    28.261  ? 540  PRO A CG    1 ? 
ATOM   3863  C  CD    . PRO A 1 540 ? -23.646 29.131  -3.626   1    21.547  ? 540  PRO A CD    1 ? 
ATOM   3864  N  N     . ILE A 1 541 ? -23.925 27.626  -7.079   1    17.035  ? 541  ILE A N     1 ? 
ATOM   3865  C  CA    . ILE A 1 541 ? -23.805 26.705  -8.205   1    19.457  ? 541  ILE A CA    1 ? 
ATOM   3866  C  C     . ILE A 1 541 ? -25.063 25.847  -8.321   1    17.105  ? 541  ILE A C     1 ? 
ATOM   3867  O  O     . ILE A 1 541 ? -25.05  24.811  -8.982   1    16.563  ? 541  ILE A O     1 ? 
ATOM   3868  C  CB    . ILE A 1 541 ? -22.524 25.845  -8.037   1    21.111  ? 541  ILE A CB    1 ? 
ATOM   3869  C  CG1   . ILE A 1 541 ? -22.479 25.103  -6.695   1    20.522  ? 541  ILE A CG1   1 ? 
ATOM   3870  C  CG2   . ILE A 1 541 ? -21.301 26.755  -8.21    1    19.991  ? 541  ILE A CG2   1 ? 
ATOM   3871  C  CD1   . ILE A 1 541 ? -21.338 24.079  -6.514   1    17.176  ? 541  ILE A CD1   1 ? 
ATOM   3872  N  N     . ILE A 1 542 ? -26.197 26.307  -7.767   1    17.36   ? 542  ILE A N     1 ? 
ATOM   3873  C  CA    . ILE A 1 542 ? -27.428 25.491  -7.83    1    17.224  ? 542  ILE A CA    1 ? 
ATOM   3874  C  C     . ILE A 1 542 ? -27.775 25.129  -9.278   1    17.247  ? 542  ILE A C     1 ? 
ATOM   3875  O  O     . ILE A 1 542 ? -28.332 24.046  -9.575   1    17.517  ? 542  ILE A O     1 ? 
ATOM   3876  C  CB    . ILE A 1 542 ? -28.612 26.188  -7.113   1    19.513  ? 542  ILE A CB    1 ? 
ATOM   3877  C  CG1   . ILE A 1 542 ? -29.825 25.224  -6.942   1    23.465  ? 542  ILE A CG1   1 ? 
ATOM   3878  C  CG2   . ILE A 1 542 ? -29.056 27.467  -7.86    1    17.537  ? 542  ILE A CG2   1 ? 
ATOM   3879  C  CD1   . ILE A 1 542 ? -29.515 23.926  -6.212   1    20.869  ? 542  ILE A CD1   1 ? 
ATOM   3880  N  N     . GLU A 1 543 ? -27.503 26.051  -10.202  1    17.116  ? 543  GLU A N     1 ? 
ATOM   3881  C  CA    . GLU A 1 543 ? -27.874 25.828  -11.6    1    20.574  ? 543  GLU A CA    1 ? 
ATOM   3882  C  C     . GLU A 1 543 ? -27.213 24.589  -12.19   1    19.214  ? 543  GLU A C     1 ? 
ATOM   3883  O  O     . GLU A 1 543 ? -27.651 24.094  -13.228  1    21.003  ? 543  GLU A O     1 ? 
ATOM   3884  C  CB    . GLU A 1 543 ? -27.711 27.06   -12.519  1    26.118  ? 543  GLU A CB    1 ? 
ATOM   3885  C  CG    . GLU A 1 543 ? -26.254 27.311  -12.901  1    37.628  ? 543  GLU A CG    1 ? 
ATOM   3886  C  CD    . GLU A 1 543 ? -25.728 28.729  -13.136  1    45.318  ? 543  GLU A CD    1 ? 
ATOM   3887  O  OE1   . GLU A 1 543 ? -25.166 28.94   -14.225  1    43.132  ? 543  GLU A OE1   1 ? 
ATOM   3888  O  OE2   . GLU A 1 543 ? -25.844 29.615  -12.247  1    49.436  ? 543  GLU A OE2   1 ? 
ATOM   3889  N  N     . TYR A 1 544 ? -26.189 24.032  -11.529  1    20.489  ? 544  TYR A N     1 ? 
ATOM   3890  C  CA    . TYR A 1 544 ? -25.543 22.85   -12.078  1    20.432  ? 544  TYR A CA    1 ? 
ATOM   3891  C  C     . TYR A 1 544 ? -26.298 21.565  -11.721  1    22.667  ? 544  TYR A C     1 ? 
ATOM   3892  O  O     . TYR A 1 544 ? -25.911 20.495  -12.19   1    19.809  ? 544  TYR A O     1 ? 
ATOM   3893  C  CB    . TYR A 1 544 ? -24.09  22.798  -11.587  1    23.278  ? 544  TYR A CB    1 ? 
ATOM   3894  C  CG    . TYR A 1 544 ? -23.234 23.987  -12.034  1    23.789  ? 544  TYR A CG    1 ? 
ATOM   3895  C  CD1   . TYR A 1 544 ? -23.54  24.718  -13.17   1    24.756  ? 544  TYR A CD1   1 ? 
ATOM   3896  C  CD2   . TYR A 1 544 ? -22.097 24.347  -11.336  1    26.637  ? 544  TYR A CD2   1 ? 
ATOM   3897  C  CE1   . TYR A 1 544 ? -22.751 25.771  -13.603  1    28.104  ? 544  TYR A CE1   1 ? 
ATOM   3898  C  CE2   . TYR A 1 544 ? -21.264 25.368  -11.76   1    25.552  ? 544  TYR A CE2   1 ? 
ATOM   3899  C  CZ    . TYR A 1 544 ? -21.61  26.093  -12.887  1    34.264  ? 544  TYR A CZ    1 ? 
ATOM   3900  O  OH    . TYR A 1 544 ? -20.811 27.101  -13.297  1    33.4    ? 544  TYR A OH    1 ? 
ATOM   3901  N  N     . TYR A 1 545 ? -27.32  21.644  -10.86   1    18.445  ? 545  TYR A N     1 ? 
ATOM   3902  C  CA    . TYR A 1 545 ? -27.907 20.405  -10.371  1    18.569  ? 545  TYR A CA    1 ? 
ATOM   3903  C  C     . TYR A 1 545 ? -29.416 20.392  -10.652  1    19.992  ? 545  TYR A C     1 ? 
ATOM   3904  O  O     . TYR A 1 545 ? -30.214 20.188  -9.733   1    20.028  ? 545  TYR A O     1 ? 
ATOM   3905  C  CB    . TYR A 1 545 ? -27.597 20.261  -8.869   1    18.117  ? 545  TYR A CB    1 ? 
ATOM   3906  C  CG    . TYR A 1 545 ? -26.087 20.311  -8.645   1    19.418  ? 545  TYR A CG    1 ? 
ATOM   3907  C  CD1   . TYR A 1 545 ? -25.299 19.19   -8.904   1    19.992  ? 545  TYR A CD1   1 ? 
ATOM   3908  C  CD2   . TYR A 1 545 ? -25.435 21.488  -8.269   1    17.622  ? 545  TYR A CD2   1 ? 
ATOM   3909  C  CE1   . TYR A 1 545 ? -23.911 19.249  -8.806   1    19.653  ? 545  TYR A CE1   1 ? 
ATOM   3910  C  CE2   . TYR A 1 545 ? -24.042 21.546  -8.135   1    19.633  ? 545  TYR A CE2   1 ? 
ATOM   3911  C  CZ    . TYR A 1 545 ? -23.283 20.412  -8.397   1    19.989  ? 545  TYR A CZ    1 ? 
ATOM   3912  O  OH    . TYR A 1 545 ? -21.919 20.418  -8.324   1    20.131  ? 545  TYR A OH    1 ? 
ATOM   3913  N  N     . PRO A 1 546 ? -29.883 20.567  -11.9    1    21.759  ? 546  PRO A N     1 ? 
ATOM   3914  C  CA    . PRO A 1 546 ? -31.33  20.626  -12.139  1    23.043  ? 546  PRO A CA    1 ? 
ATOM   3915  C  C     . PRO A 1 546 ? -31.984 19.29   -11.779  1    21.974  ? 546  PRO A C     1 ? 
ATOM   3916  O  O     . PRO A 1 546 ? -31.553 18.231  -12.247  1    22.323  ? 546  PRO A O     1 ? 
ATOM   3917  C  CB    . PRO A 1 546 ? -31.424 20.978  -13.653  1    20.852  ? 546  PRO A CB    1 ? 
ATOM   3918  C  CG    . PRO A 1 546 ? -30.105 20.41   -14.231  1    21.441  ? 546  PRO A CG    1 ? 
ATOM   3919  C  CD    . PRO A 1 546 ? -29.083 20.66   -13.14   1    21.706  ? 546  PRO A CD    1 ? 
ATOM   3920  N  N     . PRO A 1 547 ? -33.027 19.26   -10.912  1    22.517  ? 547  PRO A N     1 ? 
ATOM   3921  C  CA    . PRO A 1 547 ? -33.763 18.006  -10.687  1    23.443  ? 547  PRO A CA    1 ? 
ATOM   3922  C  C     . PRO A 1 547 ? -34.443 17.489  -11.954  1    22.563  ? 547  PRO A C     1 ? 
ATOM   3923  O  O     . PRO A 1 547 ? -34.647 16.297  -12.076  1    20.738  ? 547  PRO A O     1 ? 
ATOM   3924  C  CB    . PRO A 1 547 ? -34.8   18.296  -9.566   1    21.5    ? 547  PRO A CB    1 ? 
ATOM   3925  C  CG    . PRO A 1 547 ? -34.868 19.821  -9.535   1    20.749  ? 547  PRO A CG    1 ? 
ATOM   3926  C  CD    . PRO A 1 547 ? -33.532 20.376  -10.08   1    18.049  ? 547  PRO A CD    1 ? 
ATOM   3927  N  N     . ASP A 1 548 ? -34.772 18.368  -12.899  1    23.687  ? 548  ASP A N     1 ? 
ATOM   3928  C  CA    . ASP A 1 548 ? -35.385 17.889  -14.141  1    25.787  ? 548  ASP A CA    1 ? 
ATOM   3929  C  C     . ASP A 1 548 ? -34.602 18.437  -15.335  1    20.98   ? 548  ASP A C     1 ? 
ATOM   3930  O  O     . ASP A 1 548 ? -34.146 19.564  -15.317  1    25.415  ? 548  ASP A O     1 ? 
ATOM   3931  C  CB    . ASP A 1 548 ? -36.823 18.39   -14.252  1    30.363  ? 548  ASP A CB    1 ? 
ATOM   3932  C  CG    . ASP A 1 548 ? -37.627 18.211  -12.97   1    33.369  ? 548  ASP A CG    1 ? 
ATOM   3933  O  OD1   . ASP A 1 548 ? -37.925 17.063  -12.67   1    38.14   ? 548  ASP A OD1   1 ? 
ATOM   3934  O  OD2   . ASP A 1 548 ? -37.877 19.211  -12.25   1    42.551  ? 548  ASP A OD2   1 ? 
ATOM   3935  N  N     . PHE A 1 549 ? -34.544 17.686  -16.425  1    20.224  ? 549  PHE A N     1 ? 
ATOM   3936  C  CA    . PHE A 1 549 ? -33.689 18.073  -17.524  1    25.034  ? 549  PHE A CA    1 ? 
ATOM   3937  C  C     . PHE A 1 549 ? -34.188 17.28   -18.713  1    24.595  ? 549  PHE A C     1 ? 
ATOM   3938  O  O     . PHE A 1 549 ? -34.778 16.233  -18.519  1    27.185  ? 549  PHE A O     1 ? 
ATOM   3939  C  CB    . PHE A 1 549 ? -32.194 17.771  -17.236  1    20.97   ? 549  PHE A CB    1 ? 
ATOM   3940  C  CG    . PHE A 1 549 ? -31.943 16.334  -16.792  1    20.39   ? 549  PHE A CG    1 ? 
ATOM   3941  C  CD1   . PHE A 1 549 ? -31.734 15.326  -17.718  1    19.356  ? 549  PHE A CD1   1 ? 
ATOM   3942  C  CD2   . PHE A 1 549 ? -31.933 15.994  -15.444  1    21.345  ? 549  PHE A CD2   1 ? 
ATOM   3943  C  CE1   . PHE A 1 549 ? -31.565 14.015  -17.327  1    18.821  ? 549  PHE A CE1   1 ? 
ATOM   3944  C  CE2   . PHE A 1 549 ? -31.797 14.667  -15.054  1    21.397  ? 549  PHE A CE2   1 ? 
ATOM   3945  C  CZ    . PHE A 1 549 ? -31.552 13.694  -15.98   1    20.77   ? 549  PHE A CZ    1 ? 
ATOM   3946  N  N     . LYS A 1 550 ? -33.869 17.741  -19.928  1    32.868  ? 550  LYS A N     1 ? 
ATOM   3947  C  CA    . LYS A 1 550 ? -34.181 16.979  -21.127  1    33.984  ? 550  LYS A CA    1 ? 
ATOM   3948  C  C     . LYS A 1 550 ? -33     16.102  -21.533  1    32.33   ? 550  LYS A C     1 ? 
ATOM   3949  O  O     . LYS A 1 550 ? -31.83  16.467  -21.361  1    27.054  ? 550  LYS A O     1 ? 
ATOM   3950  C  CB    . LYS A 1 550 ? -34.555 17.864  -22.324  1    44.03   ? 550  LYS A CB    1 ? 
ATOM   3951  C  CG    . LYS A 1 550 ? -35.805 18.742  -22.131  1    63.965  ? 550  LYS A CG    1 ? 
ATOM   3952  C  CD    . LYS A 1 550 ? -37.073 18.083  -21.581  1    63.342  ? 550  LYS A CD    1 ? 
ATOM   3953  C  CE    . LYS A 1 550 ? -38.258 19.017  -21.468  1    74.127  ? 550  LYS A CE    1 ? 
ATOM   3954  N  NZ    . LYS A 1 550 ? -39.312 18.497  -20.592  1    66.149  ? 550  LYS A NZ    1 ? 
ATOM   3955  N  N     . THR A 1 551 ? -33.344 14.93   -22.076  1    30.256  ? 551  THR A N     1 ? 
ATOM   3956  C  CA    . THR A 1 551 ? -32.408 13.983  -22.646  1    37.875  ? 551  THR A CA    1 ? 
ATOM   3957  C  C     . THR A 1 551 ? -32.83  13.788  -24.093  1    40.344  ? 551  THR A C     1 ? 
ATOM   3958  O  O     . THR A 1 551 ? -33.979 13.422  -24.34   1    39.783  ? 551  THR A O     1 ? 
ATOM   3959  C  CB    . THR A 1 551 ? -32.453 12.643  -21.918  1    39.182  ? 551  THR A CB    1 ? 
ATOM   3960  O  OG1   . THR A 1 551 ? -32.179 12.887  -20.542  1    38.752  ? 551  THR A OG1   1 ? 
ATOM   3961  C  CG2   . THR A 1 551 ? -31.422 11.663  -22.451  1    36.045  ? 551  THR A CG2   1 ? 
ATOM   3962  N  N     . ASP A 1 552 ? -31.915 14.108  -25.012  1    34.761  ? 552  ASP A N     1 ? 
ATOM   3963  C  CA    . ASP A 1 552 ? -32.032 13.734  -26.409  1    39.156  ? 552  ASP A CA    1 ? 
ATOM   3964  C  C     . ASP A 1 552 ? -31.781 12.227  -26.556  1    44.314  ? 552  ASP A C     1 ? 
ATOM   3965  O  O     . ASP A 1 552 ? -30.657 11.748  -26.374  1    41.452  ? 552  ASP A O     1 ? 
ATOM   3966  C  CB    . ASP A 1 552 ? -31.191 14.673  -27.25   1    41.58   ? 552  ASP A CB    1 ? 
ATOM   3967  C  CG    . ASP A 1 552 ? -31.131 14.356  -28.74   1    52.572  ? 552  ASP A CG    1 ? 
ATOM   3968  O  OD1   . ASP A 1 552 ? -31.496 13.219  -29.117  1    58.82   ? 552  ASP A OD1   1 ? 
ATOM   3969  O  OD2   . ASP A 1 552 ? -30.741 15.259  -29.51   1    52.871  ? 552  ASP A OD2   1 ? 
ATOM   3970  N  N     . LEU A 1 553 ? -32.849 11.482  -26.888  1    49.99   ? 553  LEU A N     1 ? 
ATOM   3971  C  CA    . LEU A 1 553 ? -32.849 10.021  -26.856  1    60.378  ? 553  LEU A CA    1 ? 
ATOM   3972  C  C     . LEU A 1 553 ? -32.96  9.398   -28.254  1    68.289  ? 553  LEU A C     1 ? 
ATOM   3973  O  O     . LEU A 1 553 ? -33.353 8.236   -28.369  1    70.233  ? 553  LEU A O     1 ? 
ATOM   3974  C  CB    . LEU A 1 553 ? -33.963 9.504   -25.939  1    59.973  ? 553  LEU A CB    1 ? 
ATOM   3975  C  CG    . LEU A 1 553 ? -33.625 9.271   -24.46   1    61.85   ? 553  LEU A CG    1 ? 
ATOM   3976  C  CD1   . LEU A 1 553 ? -34.929 9.15    -23.682  1    66.305  ? 553  LEU A CD1   1 ? 
ATOM   3977  C  CD2   . LEU A 1 553 ? -32.777 8.021   -24.243  1    65.937  ? 553  LEU A CD2   1 ? 
ATOM   3978  N  N     . ASN A 1 554 ? -32.594 10.138  -29.313  1    72.252  ? 554  ASN A N     1 ? 
ATOM   3979  C  CA    . ASN A 1 554 ? -32.665 9.613   -30.674  1    78.395  ? 554  ASN A CA    1 ? 
ATOM   3980  C  C     . ASN A 1 554 ? -31.79  8.366   -30.816  1    80.367  ? 554  ASN A C     1 ? 
ATOM   3981  O  O     . ASN A 1 554 ? -30.588 8.425   -30.573  1    79.975  ? 554  ASN A O     1 ? 
ATOM   3982  C  CB    . ASN A 1 554 ? -32.265 10.648  -31.724  1    81.181  ? 554  ASN A CB    1 ? 
ATOM   3983  C  CG    . ASN A 1 554 ? -33.039 11.943  -31.632  1    84.7    ? 554  ASN A CG    1 ? 
ATOM   3984  O  OD1   . ASN A 1 554 ? -34.266 11.94   -31.467  1    81.637  ? 554  ASN A OD1   1 ? 
ATOM   3985  N  ND2   . ASN A 1 554 ? -32.341 13.064  -31.746  1    87.224  ? 554  ASN A ND2   1 ? 
ATOM   3986  N  N     . GLY A 1 555 ? -32.4   7.242   -31.227  1    84.782  ? 555  GLY A N     1 ? 
ATOM   3987  C  CA    . GLY A 1 555 ? -31.678 5.991   -31.426  1    82.852  ? 555  GLY A CA    1 ? 
ATOM   3988  C  C     . GLY A 1 555 ? -32.489 4.793   -30.969  1    75.008  ? 555  GLY A C     1 ? 
ATOM   3989  O  O     . GLY A 1 555 ? -31.939 4.015   -30.164  1    78.448  ? 555  GLY A O     1 ? 
ATOM   3990  N  N     . GLU A 1 559 ? -27.728 1.234   -29.896  1    61.707  ? 559  GLU A N     1 ? 
ATOM   3991  C  CA    . GLU A 1 559 ? -27.176 2.012   -31.04   1    79.792  ? 559  GLU A CA    1 ? 
ATOM   3992  C  C     . GLU A 1 559 ? -26.635 3.368   -30.559  1    82.061  ? 559  GLU A C     1 ? 
ATOM   3993  O  O     . GLU A 1 559 ? -25.453 3.483   -30.225  1    75.345  ? 559  GLU A O     1 ? 
ATOM   3994  C  CB    . GLU A 1 559 ? -28.145 2.025   -32.232  1    73.285  ? 559  GLU A CB    1 ? 
ATOM   3995  C  CG    . GLU A 1 559 ? -29.607 2.23    -31.838  1    74.562  ? 559  GLU A CG    1 ? 
ATOM   3996  C  CD    . GLU A 1 559 ? -30.623 2.079   -32.956  1    82.841  ? 559  GLU A CD    1 ? 
ATOM   3997  O  OE1   . GLU A 1 559 ? -30.382 2.665   -34.038  1    79.379  ? 559  GLU A OE1   1 ? 
ATOM   3998  O  OE2   . GLU A 1 559 ? -31.659 1.396   -32.743  1    78.206  ? 559  GLU A OE2   1 ? 
ATOM   3999  N  N     . TRP A 1 560 ? -27.499 4.394   -30.523  1    85.266  ? 560  TRP A N     1 ? 
ATOM   4000  C  CA    . TRP A 1 560 ? -27.046 5.772   -30.379  1    90.368  ? 560  TRP A CA    1 ? 
ATOM   4001  C  C     . TRP A 1 560 ? -26.947 6.173   -28.907  1    86.991  ? 560  TRP A C     1 ? 
ATOM   4002  O  O     . TRP A 1 560 ? -27.571 5.556   -28.046  1    89.435  ? 560  TRP A O     1 ? 
ATOM   4003  C  CB    . TRP A 1 560 ? -27.957 6.721   -31.172  1    93.03   ? 560  TRP A CB    1 ? 
ATOM   4004  C  CG    . TRP A 1 560 ? -27.784 6.643   -32.667  1    108.502 ? 560  TRP A CG    1 ? 
ATOM   4005  C  CD1   . TRP A 1 560 ? -26.973 5.799   -33.37   1    112.976 ? 560  TRP A CD1   1 ? 
ATOM   4006  C  CD2   . TRP A 1 560 ? -28.484 7.436   -33.651  1    114.197 ? 560  TRP A CD2   1 ? 
ATOM   4007  N  NE1   . TRP A 1 560 ? -27.099 6.021   -34.715  1    111.114 ? 560  TRP A NE1   1 ? 
ATOM   4008  C  CE2   . TRP A 1 560 ? -28.023 7.014   -34.921  1    115.461 ? 560  TRP A CE2   1 ? 
ATOM   4009  C  CE3   . TRP A 1 560 ? -29.445 8.454   -33.585  1    106.474 ? 560  TRP A CE3   1 ? 
ATOM   4010  C  CZ2   . TRP A 1 560 ? -28.495 7.577   -36.108  1    111.152 ? 560  TRP A CZ2   1 ? 
ATOM   4011  C  CZ3   . TRP A 1 560 ? -29.908 9.007   -34.76   1    110.703 ? 560  TRP A CZ3   1 ? 
ATOM   4012  C  CH2   . TRP A 1 560 ? -29.441 8.573   -36.003  1    109.341 ? 560  TRP A CH2   1 ? 
ATOM   4013  N  N     . GLU A 1 561 ? -26.156 7.224   -28.644  1    74.597  ? 561  GLU A N     1 ? 
ATOM   4014  C  CA    . GLU A 1 561 ? -25.891 7.699   -27.293  1    75.712  ? 561  GLU A CA    1 ? 
ATOM   4015  C  C     . GLU A 1 561 ? -26.827 8.859   -26.936  1    62.78   ? 561  GLU A C     1 ? 
ATOM   4016  O  O     . GLU A 1 561 ? -26.992 9.804   -27.71   1    53.498  ? 561  GLU A O     1 ? 
ATOM   4017  C  CB    . GLU A 1 561 ? -24.411 8.077   -27.196  1    86.431  ? 561  GLU A CB    1 ? 
ATOM   4018  C  CG    . GLU A 1 561 ? -23.891 8.144   -25.762  1    100.495 ? 561  GLU A CG    1 ? 
ATOM   4019  C  CD    . GLU A 1 561 ? -22.403 8.432   -25.722  1    110.027 ? 561  GLU A CD    1 ? 
ATOM   4020  O  OE1   . GLU A 1 561 ? -21.998 9.434   -25.095  1    106.243 ? 561  GLU A OE1   1 ? 
ATOM   4021  O  OE2   . GLU A 1 561 ? -21.654 7.644   -26.34   1    116.676 ? 561  GLU A OE2   1 ? 
ATOM   4022  N  N     . ALA A 1 562 ? -27.445 8.761   -25.749  1    51.038  ? 562  ALA A N     1 ? 
ATOM   4023  C  CA    . ALA A 1 562 ? -28.261 9.82    -25.18   1    41.299  ? 562  ALA A CA    1 ? 
ATOM   4024  C  C     . ALA A 1 562 ? -27.418 11.074  -24.957  1    38.124  ? 562  ALA A C     1 ? 
ATOM   4025  O  O     . ALA A 1 562 ? -26.271 11.007  -24.525  1    42.967  ? 562  ALA A O     1 ? 
ATOM   4026  C  CB    . ALA A 1 562 ? -28.875 9.337   -23.88   1    45.337  ? 562  ALA A CB    1 ? 
ATOM   4027  N  N     . VAL A 1 563 ? -28.003 12.227  -25.259  1    32.902  ? 563  VAL A N     1 ? 
ATOM   4028  C  CA    . VAL A 1 563 ? -27.371 13.501  -24.984  1    29.577  ? 563  VAL A CA    1 ? 
ATOM   4029  C  C     . VAL A 1 563 ? -28.157 14.103  -23.819  1    28.591  ? 563  VAL A C     1 ? 
ATOM   4030  O  O     . VAL A 1 563 ? -29.36  14.309  -23.942  1    28.523  ? 563  VAL A O     1 ? 
ATOM   4031  C  CB    . VAL A 1 563 ? -27.408 14.423  -26.221  1    31.221  ? 563  VAL A CB    1 ? 
ATOM   4032  C  CG1   . VAL A 1 563 ? -26.805 15.788  -25.922  1    27.2    ? 563  VAL A CG1   1 ? 
ATOM   4033  C  CG2   . VAL A 1 563 ? -26.696 13.823  -27.426  1    38.058  ? 563  VAL A CG2   1 ? 
ATOM   4034  N  N     . VAL A 1 564 ? -27.491 14.326  -22.682  1    25.503  ? 564  VAL A N     1 ? 
ATOM   4035  C  CA    . VAL A 1 564 ? -28.13  14.874  -21.5    1    25.139  ? 564  VAL A CA    1 ? 
ATOM   4036  C  C     . VAL A 1 564 ? -27.89  16.38   -21.435  1    28.18   ? 564  VAL A C     1 ? 
ATOM   4037  O  O     . VAL A 1 564 ? -26.741 16.82   -21.363  1    26.906  ? 564  VAL A O     1 ? 
ATOM   4038  C  CB    . VAL A 1 564 ? -27.599 14.179  -20.236  1    23.813  ? 564  VAL A CB    1 ? 
ATOM   4039  C  CG1   . VAL A 1 564 ? -28.275 14.781  -19.017  1    22.337  ? 564  VAL A CG1   1 ? 
ATOM   4040  C  CG2   . VAL A 1 564 ? -27.84  12.659  -20.273  1    22.337  ? 564  VAL A CG2   1 ? 
ATOM   4041  N  N     . LEU A 1 565 ? -28.982 17.16   -21.427  1    22.145  ? 565  LEU A N     1 ? 
ATOM   4042  C  CA    . LEU A 1 565 ? -28.886 18.596  -21.637  1    23.807  ? 565  LEU A CA    1 ? 
ATOM   4043  C  C     . LEU A 1 565 ? -28.884 19.281  -20.276  1    23.515  ? 565  LEU A C     1 ? 
ATOM   4044  O  O     . LEU A 1 565 ? -29.923 19.71   -19.786  1    22.104  ? 565  LEU A O     1 ? 
ATOM   4045  C  CB    . LEU A 1 565 ? -30.016 19.099  -22.543  1    26.572  ? 565  LEU A CB    1 ? 
ATOM   4046  C  CG    . LEU A 1 565 ? -30.141 18.422  -23.924  1    31.675  ? 565  LEU A CG    1 ? 
ATOM   4047  C  CD1   . LEU A 1 565 ? -31.369 18.912  -24.7    1    28.832  ? 565  LEU A CD1   1 ? 
ATOM   4048  C  CD2   . LEU A 1 565 ? -28.922 18.654  -24.772  1    27.952  ? 565  LEU A CD2   1 ? 
ATOM   4049  N  N     . ILE A 1 566 ? -27.717 19.282  -19.625  1    20.148  ? 566  ILE A N     1 ? 
ATOM   4050  C  CA    . ILE A 1 566 ? -27.554 19.903  -18.327  1    20.65   ? 566  ILE A CA    1 ? 
ATOM   4051  C  C     . ILE A 1 566 ? -26.36  20.825  -18.524  1    20.625  ? 566  ILE A C     1 ? 
ATOM   4052  O  O     . ILE A 1 566 ? -25.668 20.682  -19.524  1    23.21   ? 566  ILE A O     1 ? 
ATOM   4053  C  CB    . ILE A 1 566 ? -27.341 18.837  -17.227  1    19.372  ? 566  ILE A CB    1 ? 
ATOM   4054  C  CG1   . ILE A 1 566 ? -26.157 17.912  -17.616  1    20.23   ? 566  ILE A CG1   1 ? 
ATOM   4055  C  CG2   . ILE A 1 566 ? -28.661 18.067  -17.023  1    18.532  ? 566  ILE A CG2   1 ? 
ATOM   4056  C  CD1   . ILE A 1 566 ? -25.793 16.803  -16.635  1    22.613  ? 566  ILE A CD1   1 ? 
ATOM   4057  N  N     . PRO A 1 567 ? -26.182 21.851  -17.684  1    19.264  ? 567  PRO A N     1 ? 
ATOM   4058  C  CA    . PRO A 1 567 ? -25.137 22.853  -17.901  1    23.204  ? 567  PRO A CA    1 ? 
ATOM   4059  C  C     . PRO A 1 567 ? -23.707 22.323  -17.751  1    22.974  ? 567  PRO A C     1 ? 
ATOM   4060  O  O     . PRO A 1 567 ? -23.462 21.349  -17.061  1    23.159  ? 567  PRO A O     1 ? 
ATOM   4061  C  CB    . PRO A 1 567 ? -25.439 23.859  -16.778  1    20.593  ? 567  PRO A CB    1 ? 
ATOM   4062  C  CG    . PRO A 1 567 ? -26.929 23.656  -16.479  1    24.059  ? 567  PRO A CG    1 ? 
ATOM   4063  C  CD    . PRO A 1 567 ? -27.027 22.135  -16.505  1    20.516  ? 567  PRO A CD    1 ? 
ATOM   4064  N  N     . PHE A 1 568 ? -22.773 22.989  -18.418  1    23.349  ? 568  PHE A N     1 ? 
ATOM   4065  C  CA    . PHE A 1 568 ? -21.357 22.74   -18.247  1    23.947  ? 568  PHE A CA    1 ? 
ATOM   4066  C  C     . PHE A 1 568 ? -20.884 23.497  -17.014  1    25.642  ? 568  PHE A C     1 ? 
ATOM   4067  O  O     . PHE A 1 568 ? -21.121 24.7    -16.889  1    29.744  ? 568  PHE A O     1 ? 
ATOM   4068  C  CB    . PHE A 1 568 ? -20.689 23.318  -19.504  1    23.218  ? 568  PHE A CB    1 ? 
ATOM   4069  C  CG    . PHE A 1 568 ? -20.929 22.399  -20.695  1    22.76   ? 568  PHE A CG    1 ? 
ATOM   4070  C  CD1   . PHE A 1 568 ? -20.159 21.251  -20.877  1    20.455  ? 568  PHE A CD1   1 ? 
ATOM   4071  C  CD2   . PHE A 1 568 ? -21.937 22.679  -21.606  1    22.779  ? 568  PHE A CD2   1 ? 
ATOM   4072  C  CE1   . PHE A 1 568 ? -20.368 20.399  -21.962  1    20.678  ? 568  PHE A CE1   1 ? 
ATOM   4073  C  CE2   . PHE A 1 568 ? -22.173 21.804  -22.663  1    25.364  ? 568  PHE A CE2   1 ? 
ATOM   4074  C  CZ    . PHE A 1 568 ? -21.386 20.66   -22.839  1    23.703  ? 568  PHE A CZ    1 ? 
ATOM   4075  N  N     . ILE A 1 569 ? -20.157 22.81   -16.141  1    25.249  ? 569  ILE A N     1 ? 
ATOM   4076  C  CA    . ILE A 1 569 ? -19.633 23.439  -14.942  1    26.133  ? 569  ILE A CA    1 ? 
ATOM   4077  C  C     . ILE A 1 569 ? -18.454 24.357  -15.284  1    26.166  ? 569  ILE A C     1 ? 
ATOM   4078  O  O     . ILE A 1 569 ? -17.574 23.999  -16.06   1    24.949  ? 569  ILE A O     1 ? 
ATOM   4079  C  CB    . ILE A 1 569 ? -19.269 22.294  -13.993  1    26.702  ? 569  ILE A CB    1 ? 
ATOM   4080  C  CG1   . ILE A 1 569 ? -20.56  21.796  -13.362  1    23.114  ? 569  ILE A CG1   1 ? 
ATOM   4081  C  CG2   . ILE A 1 569 ? -18.19  22.655  -12.969  1    19.615  ? 569  ILE A CG2   1 ? 
ATOM   4082  C  CD1   . ILE A 1 569 ? -20.351 20.745  -12.319  1    19.19   ? 569  ILE A CD1   1 ? 
ATOM   4083  N  N     . ASP A 1 570 ? -18.454 25.544  -14.675  1    23.953  ? 570  ASP A N     1 ? 
ATOM   4084  C  CA    . ASP A 1 570 ? -17.28  26.398  -14.649  1    25.941  ? 570  ASP A CA    1 ? 
ATOM   4085  C  C     . ASP A 1 570 ? -16.46  26.019  -13.406  1    21.286  ? 570  ASP A C     1 ? 
ATOM   4086  O  O     . ASP A 1 570 ? -16.887 26.242  -12.283  1    20.669  ? 570  ASP A O     1 ? 
ATOM   4087  C  CB    . ASP A 1 570 ? -17.726 27.86   -14.67   1    28.46   ? 570  ASP A CB    1 ? 
ATOM   4088  C  CG    . ASP A 1 570 ? -16.651 28.928  -14.493  1    35.671  ? 570  ASP A CG    1 ? 
ATOM   4089  O  OD1   . ASP A 1 570 ? -15.532 28.612  -14.107  1    40.436  ? 570  ASP A OD1   1 ? 
ATOM   4090  O  OD2   . ASP A 1 570 ? -16.937 30.087  -14.756  1    49.774  ? 570  ASP A OD2   1 ? 
ATOM   4091  N  N     . GLU A 1 571 ? -15.236 25.501  -13.575  1    22.863  ? 571  GLU A N     1 ? 
ATOM   4092  C  CA    . GLU A 1 571 ? -14.511 24.952  -12.438  1    24.193  ? 571  GLU A CA    1 ? 
ATOM   4093  C  C     . GLU A 1 571 ? -14.157 26.05   -11.442  1    25.064  ? 571  GLU A C     1 ? 
ATOM   4094  O  O     . GLU A 1 571 ? -14.12  25.809  -10.229  1    20.713  ? 571  GLU A O     1 ? 
ATOM   4095  C  CB    . GLU A 1 571 ? -13.294 24.107  -12.855  1    28.371  ? 571  GLU A CB    1 ? 
ATOM   4096  C  CG    . GLU A 1 571 ? -12.061 24.905  -13.261  1    29.403  ? 571  GLU A CG    1 ? 
ATOM   4097  C  CD    . GLU A 1 571 ? -10.917 23.952  -13.604  1    31.244  ? 571  GLU A CD    1 ? 
ATOM   4098  O  OE1   . GLU A 1 571 ? -11.112 22.969  -14.362  1    27.383  ? 571  GLU A OE1   1 ? 
ATOM   4099  O  OE2   . GLU A 1 571 ? -9.845  24.186  -13.029  1    33.839  ? 571  GLU A OE2   1 ? 
ATOM   4100  N  N     . LYS A 1 572 ? -13.969 27.281  -11.944  1    22.622  ? 572  LYS A N     1 ? 
ATOM   4101  C  CA    . LYS A 1 572 ? -13.678 28.377  -11.02   1    25.481  ? 572  LYS A CA    1 ? 
ATOM   4102  C  C     . LYS A 1 572 ? -14.842 28.638  -10.051  1    22.057  ? 572  LYS A C     1 ? 
ATOM   4103  O  O     . LYS A 1 572 ? -14.664 28.951  -8.871   1    17.799  ? 572  LYS A O     1 ? 
ATOM   4104  C  CB    . LYS A 1 572 ? -13.411 29.647  -11.843  1    29.689  ? 572  LYS A CB    1 ? 
ATOM   4105  C  CG    . LYS A 1 572 ? -12.551 30.693  -11.137  1    49.438  ? 572  LYS A CG    1 ? 
ATOM   4106  C  CD    . LYS A 1 572 ? -12.783 32.169  -11.468  1    57.456  ? 572  LYS A CD    1 ? 
ATOM   4107  C  CE    . LYS A 1 572 ? -11.804 33.08   -10.779  1    58.338  ? 572  LYS A CE    1 ? 
ATOM   4108  N  NZ    . LYS A 1 572 ? -12.277 34.464  -10.683  1    55.402  ? 572  LYS A NZ    1 ? 
ATOM   4109  N  N     . ARG A 1 573 ? -16.065 28.558  -10.543  1    21.747  ? 573  ARG A N     1 ? 
ATOM   4110  C  CA    . ARG A 1 573 ? -17.169 28.769  -9.614   1    24.14   ? 573  ARG A CA    1 ? 
ATOM   4111  C  C     . ARG A 1 573 ? -17.326 27.583  -8.658   1    19.52   ? 573  ARG A C     1 ? 
ATOM   4112  O  O     . ARG A 1 573 ? -17.587 27.768  -7.475   1    19.875  ? 573  ARG A O     1 ? 
ATOM   4113  C  CB    . ARG A 1 573 ? -18.449 28.924  -10.441  1    25.592  ? 573  ARG A CB    1 ? 
ATOM   4114  C  CG    . ARG A 1 573 ? -18.455 30.271  -11.153  1    33.017  ? 573  ARG A CG    1 ? 
ATOM   4115  C  CD    . ARG A 1 573 ? -19.7   30.358  -12.043  1    36.079  ? 573  ARG A CD    1 ? 
ATOM   4116  N  NE    . ARG A 1 573 ? -20.93  30.354  -11.238  1    35.027  ? 573  ARG A NE    1 ? 
ATOM   4117  C  CZ    . ARG A 1 573 ? -22.134 30.119  -11.76   1    42.802  ? 573  ARG A CZ    1 ? 
ATOM   4118  N  NH1   . ARG A 1 573 ? -22.304 29.997  -13.077  1    39.545  ? 573  ARG A NH1   1 ? 
ATOM   4119  N  NH2   . ARG A 1 573 ? -23.172 30.001  -10.954  1    37.88   ? 573  ARG A NH2   1 ? 
ATOM   4120  N  N     . LEU A 1 574 ? -17.195 26.359  -9.178   1    19.207  ? 574  LEU A N     1 ? 
ATOM   4121  C  CA    . LEU A 1 574 ? -17.28  25.173  -8.332   1    18.673  ? 574  LEU A CA    1 ? 
ATOM   4122  C  C     . LEU A 1 574 ? -16.283 25.292  -7.169   1    18.893  ? 574  LEU A C     1 ? 
ATOM   4123  O  O     . LEU A 1 574 ? -16.641 25.142  -6.009   1    18.875  ? 574  LEU A O     1 ? 
ATOM   4124  C  CB    . LEU A 1 574 ? -17.028 23.9    -9.15    1    16.269  ? 574  LEU A CB    1 ? 
ATOM   4125  C  CG    . LEU A 1 574 ? -16.947 22.608  -8.321   1    20.422  ? 574  LEU A CG    1 ? 
ATOM   4126  C  CD1   . LEU A 1 574 ? -18.391 22.136  -7.979   1    22.683  ? 574  LEU A CD1   1 ? 
ATOM   4127  C  CD2   . LEU A 1 574 ? -16.197 21.545  -9.092   1    18.455  ? 574  LEU A CD2   1 ? 
ATOM   4128  N  N     . LEU A 1 575 ? -14.998 25.498  -7.498   1    19.103  ? 575  LEU A N     1 ? 
ATOM   4129  C  CA    . LEU A 1 575 ? -13.943 25.546  -6.492   1    22.334  ? 575  LEU A CA    1 ? 
ATOM   4130  C  C     . LEU A 1 575 ? -14.118 26.696  -5.488   1    20.895  ? 575  LEU A C     1 ? 
ATOM   4131  O  O     . LEU A 1 575 ? -13.873 26.536  -4.298   1    20.563  ? 575  LEU A O     1 ? 
ATOM   4132  C  CB    . LEU A 1 575 ? -12.58  25.651  -7.186   1    20.898  ? 575  LEU A CB    1 ? 
ATOM   4133  C  CG    . LEU A 1 575 ? -12.215 24.464  -8.092   1    26.273  ? 575  LEU A CG    1 ? 
ATOM   4134  C  CD1   . LEU A 1 575 ? -10.804 24.677  -8.73    1    27.6    ? 575  LEU A CD1   1 ? 
ATOM   4135  C  CD2   . LEU A 1 575 ? -12.23  23.237  -7.193   1    22.128  ? 575  LEU A CD2   1 ? 
ATOM   4136  N  N     . GLU A 1 576 ? -14.557 27.872  -5.942   1    21.616  ? 576  GLU A N     1 ? 
ATOM   4137  C  CA    . GLU A 1 576 ? -14.817 28.929  -4.966   1    23.631  ? 576  GLU A CA    1 ? 
ATOM   4138  C  C     . GLU A 1 576 ? -15.955 28.545  -4.012   1    21.035  ? 576  GLU A C     1 ? 
ATOM   4139  O  O     . GLU A 1 576 ? -15.878 28.802  -2.805   1    21.026  ? 576  GLU A O     1 ? 
ATOM   4140  C  CB    . GLU A 1 576 ? -15.105 30.205  -5.777   1    30.528  ? 576  GLU A CB    1 ? 
ATOM   4141  C  CG    . GLU A 1 576 ? -15.376 31.442  -4.922   1    34.649  ? 576  GLU A CG    1 ? 
ATOM   4142  C  CD    . GLU A 1 576 ? -15.688 32.629  -5.826   1    41.812  ? 576  GLU A CD    1 ? 
ATOM   4143  O  OE1   . GLU A 1 576 ? -14.757 33.238  -6.383   1    44.175  ? 576  GLU A OE1   1 ? 
ATOM   4144  O  OE2   . GLU A 1 576 ? -16.892 32.888  -6.04    1    46.93   ? 576  GLU A OE2   1 ? 
ATOM   4145  N  N     . ALA A 1 577 ? -17.029 27.91   -4.537   1    19.835  ? 577  ALA A N     1 ? 
ATOM   4146  C  CA    . ALA A 1 577 ? -18.153 27.531  -3.673   1    17.861  ? 577  ALA A CA    1 ? 
ATOM   4147  C  C     . ALA A 1 577 ? -17.641 26.51   -2.671   1    18.519  ? 577  ALA A C     1 ? 
ATOM   4148  O  O     . ALA A 1 577 ? -17.991 26.556  -1.495   1    20.026  ? 577  ALA A O     1 ? 
ATOM   4149  C  CB    . ALA A 1 577 ? -19.263 26.906  -4.536   1    17.852  ? 577  ALA A CB    1 ? 
ATOM   4150  N  N     . MET A 1 578 ? -16.754 25.61   -3.146   1    16.776  ? 578  MET A N     1 ? 
ATOM   4151  C  CA    . MET A 1 578 ? -16.285 24.528  -2.283   1    17.698  ? 578  MET A CA    1 ? 
ATOM   4152  C  C     . MET A 1 578 ? -15.449 25.02   -1.105   1    17.935  ? 578  MET A C     1 ? 
ATOM   4153  O  O     . MET A 1 578 ? -15.48  24.416  -0.031   1    18.247  ? 578  MET A O     1 ? 
ATOM   4154  C  CB    . MET A 1 578 ? -15.509 23.477  -3.085   1    20.262  ? 578  MET A CB    1 ? 
ATOM   4155  C  CG    . MET A 1 578 ? -16.435 22.627  -3.925   1    22.005  ? 578  MET A CG    1 ? 
ATOM   4156  S  SD    . MET A 1 578 ? -15.677 21.192  -4.705   1    22.798  ? 578  MET A SD    1 ? 
ATOM   4157  C  CE    . MET A 1 578 ? -15.484 20.062  -3.326   1    18.487  ? 578  MET A CE    1 ? 
ATOM   4158  N  N     . GLU A 1 579 ? -14.674 26.096  -1.305   1    22.199  ? 579  GLU A N     1 ? 
ATOM   4159  C  CA    . GLU A 1 579 ? -13.79  26.623  -0.273   1    21.857  ? 579  GLU A CA    1 ? 
ATOM   4160  C  C     . GLU A 1 579 ? -14.618 27.148  0.9      1    27.118  ? 579  GLU A C     1 ? 
ATOM   4161  O  O     . GLU A 1 579 ? -14.108 27.196  2.013    1    23.383  ? 579  GLU A O     1 ? 
ATOM   4162  C  CB    . GLU A 1 579 ? -12.851 27.65   -0.916   1    27.927  ? 579  GLU A CB    1 ? 
ATOM   4163  C  CG    . GLU A 1 579 ? -11.697 28.122  -0.019   1    31.607  ? 579  GLU A CG    1 ? 
ATOM   4164  C  CD    . GLU A 1 579 ? -10.764 27.104  0.656    1    40.808  ? 579  GLU A CD    1 ? 
ATOM   4165  O  OE1   . GLU A 1 579 ? -10.015 27.452  1.618    1    37.326  ? 579  GLU A OE1   1 ? 
ATOM   4166  O  OE2   . GLU A 1 579 ? -10.793 25.924  0.226    1    35.896  ? 579  GLU A OE2   1 ? 
ATOM   4167  N  N     . THR A 1 580 ? -15.934 27.411  0.689    1    24.079  ? 580  THR A N     1 ? 
ATOM   4168  C  CA    . THR A 1 580 ? -16.796 27.756  1.814    1    23.233  ? 580  THR A CA    1 ? 
ATOM   4169  C  C     . THR A 1 580 ? -17.08  26.54   2.704    1    26.102  ? 580  THR A C     1 ? 
ATOM   4170  O  O     . THR A 1 580 ? -17.537 26.723  3.843    1    26.23   ? 580  THR A O     1 ? 
ATOM   4171  C  CB    . THR A 1 580 ? -18.09  28.477  1.401    1    22.944  ? 580  THR A CB    1 ? 
ATOM   4172  O  OG1   . THR A 1 580 ? -18.902 27.532  0.694    1    18.809  ? 580  THR A OG1   1 ? 
ATOM   4173  C  CG2   . THR A 1 580 ? -17.773 29.679  0.513    1    20.604  ? 580  THR A CG2   1 ? 
ATOM   4174  N  N     . CYS A 1 581 ? -16.778 25.323  2.215    1    21.448  ? 581  CYS A N     1 ? 
ATOM   4175  C  CA    . CYS A 1 581 ? -17.122 24.104  2.951    1    24.36   ? 581  CYS A CA    1 ? 
ATOM   4176  C  C     . CYS A 1 581 ? -15.916 23.19   3.269    1    23.491  ? 581  CYS A C     1 ? 
ATOM   4177  O  O     . CYS A 1 581 ? -16.003 22.383  4.185    1    25.535  ? 581  CYS A O     1 ? 
ATOM   4178  C  CB    . CYS A 1 581 ? -18.007 23.227  2.084    1    23.764  ? 581  CYS A CB    1 ? 
ATOM   4179  S  SG    . CYS A 1 581 ? -19.504 24.053  1.478    1    29.689  ? 581  CYS A SG    1 ? 
ATOM   4180  N  N     . ASN A 1 582 ? -14.801 23.267  2.522    1    20.535  ? 582  ASN A N     1 ? 
ATOM   4181  C  CA    . ASN A 1 582 ? -13.694 22.305  2.638    1    23.673  ? 582  ASN A CA    1 ? 
ATOM   4182  C  C     . ASN A 1 582 ? -13.194 22.129  4.082    1    23.492  ? 582  ASN A C     1 ? 
ATOM   4183  O  O     . ASN A 1 582 ? -12.825 21.018  4.484    1    27.245  ? 582  ASN A O     1 ? 
ATOM   4184  C  CB    . ASN A 1 582 ? -12.476 22.682  1.778    1    21.479  ? 582  ASN A CB    1 ? 
ATOM   4185  C  CG    . ASN A 1 582 ? -12.71  22.544  0.294    1    24.697  ? 582  ASN A CG    1 ? 
ATOM   4186  O  OD1   . ASN A 1 582 ? -13.416 21.626  -0.18    1    24.46   ? 582  ASN A OD1   1 ? 
ATOM   4187  N  ND2   . ASN A 1 582 ? -12.162 23.48   -0.465   1    25.07   ? 582  ASN A ND2   1 ? 
ATOM   4188  N  N     . HIS A 1 583 ? -13.167 23.207  4.875    1    20.072  ? 583  HIS A N     1 ? 
ATOM   4189  C  CA    . HIS A 1 583 ? -12.541 23.161  6.197    1    26.135  ? 583  HIS A CA    1 ? 
ATOM   4190  C  C     . HIS A 1 583 ? -13.472 22.51   7.213    1    26.857  ? 583  HIS A C     1 ? 
ATOM   4191  O  O     . HIS A 1 583 ? -13.111 22.392  8.367    1    29.649  ? 583  HIS A O     1 ? 
ATOM   4192  C  CB    . HIS A 1 583 ? -12.115 24.578  6.624    1    23.798  ? 583  HIS A CB    1 ? 
ATOM   4193  C  CG    . HIS A 1 583 ? -11.074 25.079  5.682    1    26.069  ? 583  HIS A CG    1 ? 
ATOM   4194  N  ND1   . HIS A 1 583 ? -9.743  24.787  5.871    1    30.904  ? 583  HIS A ND1   1 ? 
ATOM   4195  C  CD2   . HIS A 1 583 ? -11.144 25.744  4.509    1    29.377  ? 583  HIS A CD2   1 ? 
ATOM   4196  C  CE1   . HIS A 1 583 ? -9.031  25.281  4.855    1    31.563  ? 583  HIS A CE1   1 ? 
ATOM   4197  N  NE2   . HIS A 1 583 ? -9.863  25.902  4.032    1    32.416  ? 583  HIS A NE2   1 ? 
ATOM   4198  N  N     . SER A 1 584 ? -14.69  22.152  6.782    1    28.667  ? 584  SER A N     1 ? 
ATOM   4199  C  CA    . SER A 1 584 ? -15.705 21.536  7.629    1    27.905  ? 584  SER A CA    1 ? 
ATOM   4200  C  C     . SER A 1 584 ? -15.73  20.008  7.51     1    29.889  ? 584  SER A C     1 ? 
ATOM   4201  O  O     . SER A 1 584 ? -16.579 19.369  8.119    1    29.28   ? 584  SER A O     1 ? 
ATOM   4202  C  CB    . SER A 1 584 ? -17.09  22.093  7.282    1    30.695  ? 584  SER A CB    1 ? 
ATOM   4203  O  OG    . SER A 1 584 ? -17.278 23.305  7.997    1    39.737  ? 584  SER A OG    1 ? 
ATOM   4204  N  N     . LEU A 1 585 ? -14.833 19.405  6.712    1    25.343  ? 585  LEU A N     1 ? 
ATOM   4205  C  CA    . LEU A 1 585 ? -14.817 17.95   6.536    1    23.158  ? 585  LEU A CA    1 ? 
ATOM   4206  C  C     . LEU A 1 585 ? -14.557 17.298  7.875    1    23.726  ? 585  LEU A C     1 ? 
ATOM   4207  O  O     . LEU A 1 585 ? -13.758 17.821  8.625    1    24.721  ? 585  LEU A O     1 ? 
ATOM   4208  C  CB    . LEU A 1 585 ? -13.705 17.542  5.572    1    21.069  ? 585  LEU A CB    1 ? 
ATOM   4209  C  CG    . LEU A 1 585 ? -14.012 17.916  4.121    1    24.684  ? 585  LEU A CG    1 ? 
ATOM   4210  C  CD1   . LEU A 1 585 ? -12.85  17.596  3.18     1    23.071  ? 585  LEU A CD1   1 ? 
ATOM   4211  C  CD2   . LEU A 1 585 ? -15.293 17.156  3.734    1    23.369  ? 585  LEU A CD2   1 ? 
ATOM   4212  N  N     . LYS A 1 586 ? -15.179 16.142  8.11     1    23.506  ? 586  LYS A N     1 ? 
ATOM   4213  C  CA    . LYS A 1 586 ? -14.878 15.251  9.22     1    25.412  ? 586  LYS A CA    1 ? 
ATOM   4214  C  C     . LYS A 1 586 ? -13.522 14.575  9.02     1    24.853  ? 586  LYS A C     1 ? 
ATOM   4215  O  O     . LYS A 1 586 ? -12.989 14.553  7.924    1    23.152  ? 586  LYS A O     1 ? 
ATOM   4216  C  CB    . LYS A 1 586 ? -16.026 14.242  9.347    1    28.79   ? 586  LYS A CB    1 ? 
ATOM   4217  C  CG    . LYS A 1 586 ? -17.184 14.875  10.11    1    37.268  ? 586  LYS A CG    1 ? 
ATOM   4218  C  CD    . LYS A 1 586 ? -18.601 14.725  9.557    1    48.568  ? 586  LYS A CD    1 ? 
ATOM   4219  C  CE    . LYS A 1 586 ? -19.207 13.373  9.479    1    55.148  ? 586  LYS A CE    1 ? 
ATOM   4220  N  NZ    . LYS A 1 586 ? -19.318 12.745  10.794   1    64.939  ? 586  LYS A NZ    1 ? 
ATOM   4221  N  N     . LYS A 1 587 ? -12.956 14.062  10.104   1    27.271  ? 587  LYS A N     1 ? 
ATOM   4222  C  CA    . LYS A 1 587 ? -11.605 13.507  10.1     1    33.253  ? 587  LYS A CA    1 ? 
ATOM   4223  C  C     . LYS A 1 587 ? -11.504 12.347  9.118    1    28.732  ? 587  LYS A C     1 ? 
ATOM   4224  O  O     . LYS A 1 587 ? -10.566 12.318  8.352    1    26.196  ? 587  LYS A O     1 ? 
ATOM   4225  C  CB    . LYS A 1 587 ? -11.19  13.034  11.496   1    37.089  ? 587  LYS A CB    1 ? 
ATOM   4226  C  CG    . LYS A 1 587 ? -11.219 14.176  12.487   1    50.206  ? 587  LYS A CG    1 ? 
ATOM   4227  C  CD    . LYS A 1 587 ? -11.164 13.784  13.963   1    64.954  ? 587  LYS A CD    1 ? 
ATOM   4228  C  CE    . LYS A 1 587 ? -10.001 12.919  14.345   1    58.923  ? 587  LYS A CE    1 ? 
ATOM   4229  N  NZ    . LYS A 1 587 ? -10.252 11.502  14.065   1    64.463  ? 587  LYS A NZ    1 ? 
ATOM   4230  N  N     . GLU A 1 588 ? -12.463 11.407  9.115    1    27.105  ? 588  GLU A N     1 ? 
ATOM   4231  C  CA    . GLU A 1 588 ? -12.371 10.294  8.172    1    28.916  ? 588  GLU A CA    1 ? 
ATOM   4232  C  C     . GLU A 1 588 ? -12.547 10.792  6.746    1    29.352  ? 588  GLU A C     1 ? 
ATOM   4233  O  O     . GLU A 1 588 ? -11.994 10.239  5.787    1    27.952  ? 588  GLU A O     1 ? 
ATOM   4234  C  CB    . GLU A 1 588 ? -13.311 9.13    8.498    1    39.168  ? 588  GLU A CB    1 ? 
ATOM   4235  C  CG    . GLU A 1 588 ? -13.292 7.998   7.469    1    45.358  ? 588  GLU A CG    1 ? 
ATOM   4236  C  CD    . GLU A 1 588 ? -14.203 8.003   6.226    1    56.182  ? 588  GLU A CD    1 ? 
ATOM   4237  O  OE1   . GLU A 1 588 ? -15.152 8.821   6.18     1    51.306  ? 588  GLU A OE1   1 ? 
ATOM   4238  O  OE2   . GLU A 1 588 ? -13.987 7.187   5.283    1    55.898  ? 588  GLU A OE2   1 ? 
ATOM   4239  N  N     . GLU A 1 589 ? -13.344 11.854  6.578    1    28.132  ? 589  GLU A N     1 ? 
ATOM   4240  C  CA    . GLU A 1 589 ? -13.606 12.29   5.217    1    24.757  ? 589  GLU A CA    1 ? 
ATOM   4241  C  C     . GLU A 1 589 ? -12.392 12.993  4.649    1    25.041  ? 589  GLU A C     1 ? 
ATOM   4242  O  O     . GLU A 1 589 ? -12.09  12.85   3.473    1    25.543  ? 589  GLU A O     1 ? 
ATOM   4243  C  CB    . GLU A 1 589 ? -14.701 13.366  5.216    1    25.515  ? 589  GLU A CB    1 ? 
ATOM   4244  C  CG    . GLU A 1 589 ? -16.066 12.786  5.504    1    24.356  ? 589  GLU A CG    1 ? 
ATOM   4245  C  CD    . GLU A 1 589 ? -17.206 13.76   5.8      1    23.335  ? 589  GLU A CD    1 ? 
ATOM   4246  O  OE1   . GLU A 1 589 ? -17.129 14.973  6.127    1    23.683  ? 589  GLU A OE1   1 ? 
ATOM   4247  O  OE2   . GLU A 1 589 ? -18.249 13.174  5.6      1    25.324  ? 589  GLU A OE2   1 ? 
ATOM   4248  N  N     . ARG A 1 590 ? -11.726 13.795  5.483    1    24.687  ? 590  ARG A N     1 ? 
ATOM   4249  C  CA    . ARG A 1 590 ? -10.503 14.475  5.067    1    27.001  ? 590  ARG A CA    1 ? 
ATOM   4250  C  C     . ARG A 1 590 ? -9.53   13.428  4.529    1    24.278  ? 590  ARG A C     1 ? 
ATOM   4251  O  O     . ARG A 1 590 ? -8.775  13.692  3.585    1    22.769  ? 590  ARG A O     1 ? 
ATOM   4252  C  CB    . ARG A 1 590 ? -9.823  15.234  6.217    1    29.202  ? 590  ARG A CB    1 ? 
ATOM   4253  C  CG    . ARG A 1 590 ? -10.48  16.515  6.707    1    44.706  ? 590  ARG A CG    1 ? 
ATOM   4254  C  CD    . ARG A 1 590 ? -10.273 16.926  8.182    1    48.194  ? 590  ARG A CD    1 ? 
ATOM   4255  N  NE    . ARG A 1 590 ? -8.879  17.251  8.506    1    67.015  ? 590  ARG A NE    1 ? 
ATOM   4256  C  CZ    . ARG A 1 590 ? -8.145  16.718  9.492    1    69.825  ? 590  ARG A CZ    1 ? 
ATOM   4257  N  NH1   . ARG A 1 590 ? -8.69   15.813  10.283   1    60.948  ? 590  ARG A NH1   1 ? 
ATOM   4258  N  NH2   . ARG A 1 590 ? -6.874  17.088  9.668    1    59.053  ? 590  ARG A NH2   1 ? 
ATOM   4259  N  N     . LYS A 1 591 ? -9.559  12.221  5.107    1    21.136  ? 591  LYS A N     1 ? 
ATOM   4260  C  CA    . LYS A 1 591 ? -8.581  11.215  4.694    1    20.318  ? 591  LYS A CA    1 ? 
ATOM   4261  C  C     . LYS A 1 591 ? -8.858  10.738  3.27     1    20.091  ? 591  LYS A C     1 ? 
ATOM   4262  O  O     . LYS A 1 591 ? -7.909  10.382  2.564    1    16.366  ? 591  LYS A O     1 ? 
ATOM   4263  C  CB    . LYS A 1 591 ? -8.601  9.972   5.594    1    22.854  ? 591  LYS A CB    1 ? 
ATOM   4264  C  CG    . LYS A 1 591 ? -7.99   10.257  6.926    1    32.119  ? 591  LYS A CG    1 ? 
ATOM   4265  C  CD    . LYS A 1 591 ? -7.996  9.186   8.013    1    46.615  ? 591  LYS A CD    1 ? 
ATOM   4266  C  CE    . LYS A 1 591 ? -7.729  9.931   9.313    1    46.403  ? 591  LYS A CE    1 ? 
ATOM   4267  N  NZ    . LYS A 1 591 ? -8.287  9.182   10.438   1    48.105  ? 591  LYS A NZ    1 ? 
ATOM   4268  N  N     . ARG A 1 592 ? -10.142 10.719  2.843    1    15.836  ? 592  ARG A N     1 ? 
ATOM   4269  C  CA    . ARG A 1 592 ? -10.451 10.291  1.472    1    15.508  ? 592  ARG A CA    1 ? 
ATOM   4270  C  C     . ARG A 1 592 ? -10.208 11.366  0.413    1    16.575  ? 592  ARG A C     1 ? 
ATOM   4271  O  O     . ARG A 1 592 ? -10.144 11.087  -0.808   1    19.291  ? 592  ARG A O     1 ? 
ATOM   4272  C  CB    . ARG A 1 592 ? -11.931 9.87    1.364    1    18.935  ? 592  ARG A CB    1 ? 
ATOM   4273  C  CG    . ARG A 1 592 ? -12.175 8.525   2.021    1    17.75   ? 592  ARG A CG    1 ? 
ATOM   4274  C  CD    . ARG A 1 592 ? -13.581 7.956   1.728    1    23.364  ? 592  ARG A CD    1 ? 
ATOM   4275  N  NE    . ARG A 1 592 ? -14.449 8.541   2.752    1    22.66   ? 592  ARG A NE    1 ? 
ATOM   4276  C  CZ    . ARG A 1 592 ? -15.507 9.284   2.492    1    25.094  ? 592  ARG A CZ    1 ? 
ATOM   4277  N  NH1   . ARG A 1 592 ? -16.25  9.677   3.497    1    24.375  ? 592  ARG A NH1   1 ? 
ATOM   4278  N  NH2   . ARG A 1 592 ? -15.841 9.568   1.242    1    19.355  ? 592  ARG A NH2   1 ? 
ATOM   4279  N  N     . ASN A 1 593 ? -10.072 12.619  0.834    1    15.1    ? 593  ASN A N     1 ? 
ATOM   4280  C  CA    . ASN A 1 593 ? -10.054 13.661  -0.192   1    19.389  ? 593  ASN A CA    1 ? 
ATOM   4281  C  C     . ASN A 1 593 ? -8.598  13.913  -0.648   1    19.377  ? 593  ASN A C     1 ? 
ATOM   4282  O  O     . ASN A 1 593 ? -8.098  15.024  -0.568   1    17.403  ? 593  ASN A O     1 ? 
ATOM   4283  C  CB    . ASN A 1 593 ? -10.621 14.973  0.358    1    18.265  ? 593  ASN A CB    1 ? 
ATOM   4284  C  CG    . ASN A 1 593 ? -10.949 15.96   -0.737   1    18.748  ? 593  ASN A CG    1 ? 
ATOM   4285  O  OD1   . ASN A 1 593 ? -11.236 15.561  -1.868   1    20.613  ? 593  ASN A OD1   1 ? 
ATOM   4286  N  ND2   . ASN A 1 593 ? -10.968 17.245  -0.408   1    18.202  ? 593  ASN A ND2   1 ? 
ATOM   4287  N  N     . GLN A 1 594 ? -7.908  12.89   -1.119   1    18.277  ? 594  GLN A N     1 ? 
ATOM   4288  C  CA    . GLN A 1 594 ? -6.517  13.131  -1.494   1    23.024  ? 594  GLN A CA    1 ? 
ATOM   4289  C  C     . GLN A 1 594 ? -6.135  12.23   -2.653   1    20.103  ? 594  GLN A C     1 ? 
ATOM   4290  O  O     . GLN A 1 594 ? -6.873  11.306  -3.001   1    21.856  ? 594  GLN A O     1 ? 
ATOM   4291  C  CB    . GLN A 1 594 ? -5.573  13.037  -0.3     1    27.302  ? 594  GLN A CB    1 ? 
ATOM   4292  C  CG    . GLN A 1 594 ? -5.878  11.845  0.601    1    37.731  ? 594  GLN A CG    1 ? 
ATOM   4293  C  CD    . GLN A 1 594 ? -5.685  10.489  -0.051   1    44.539  ? 594  GLN A CD    1 ? 
ATOM   4294  O  OE1   . GLN A 1 594 ? -4.721  10.268  -0.787   1    60.829  ? 594  GLN A OE1   1 ? 
ATOM   4295  N  NE2   . GLN A 1 594 ? -6.565  9.538   0.244    1    50.877  ? 594  GLN A NE2   1 ? 
ATOM   4296  N  N     . HIS A 1 595 ? -4.974  12.513  -3.232   1    17.021  ? 595  HIS A N     1 ? 
ATOM   4297  C  CA    . HIS A 1 595 ? -4.41   11.675  -4.275   1    18.608  ? 595  HIS A CA    1 ? 
ATOM   4298  C  C     . HIS A 1 595 ? -3.415  10.712  -3.654   1    21.036  ? 595  HIS A C     1 ? 
ATOM   4299  O  O     . HIS A 1 595 ? -2.661  11.089  -2.769   1    23.388  ? 595  HIS A O     1 ? 
ATOM   4300  C  CB    . HIS A 1 595 ? -3.724  12.534  -5.345   1    17.887  ? 595  HIS A CB    1 ? 
ATOM   4301  C  CG    . HIS A 1 595 ? -4.673  13.449  -6.075   1    18.629  ? 595  HIS A CG    1 ? 
ATOM   4302  N  ND1   . HIS A 1 595 ? -4.383  14.751  -6.486   1    21.816  ? 595  HIS A ND1   1 ? 
ATOM   4303  C  CD2   . HIS A 1 595 ? -5.943  13.211  -6.472   1    19.663  ? 595  HIS A CD2   1 ? 
ATOM   4304  C  CE1   . HIS A 1 595 ? -5.436  15.264  -7.104   1    23.861  ? 595  HIS A CE1   1 ? 
ATOM   4305  N  NE2   . HIS A 1 595 ? -6.402  14.327  -7.159   1    20.382  ? 595  HIS A NE2   1 ? 
ATOM   4306  N  N     . SER A 1 596 ? -3.37   9.484   -4.156   1    22.194  ? 596  SER A N     1 ? 
ATOM   4307  C  CA    A SER A 1 596 ? -2.317  8.594   -3.704   0.5  22.188  ? 596  SER A CA    1 ? 
ATOM   4308  C  CA    B SER A 1 596 ? -2.473  8.446   -3.661   0.5  22.591  ? 596  SER A CA    1 ? 
ATOM   4309  C  C     . SER A 1 596 ? -1.919  7.655   -4.838   1    21.935  ? 596  SER A C     1 ? 
ATOM   4310  O  O     . SER A 1 596 ? -2.497  7.719   -5.932   1    21.808  ? 596  SER A O     1 ? 
ATOM   4311  C  CB    A SER A 1 596 ? -2.682  7.893   -2.435   0.5  21.191  ? 596  SER A CB    1 ? 
ATOM   4312  C  CB    B SER A 1 596 ? -3.159  7.534   -2.697   0.5  23.022  ? 596  SER A CB    1 ? 
ATOM   4313  O  OG    A SER A 1 596 ? -3.581  6.84    -2.718   0.5  23.704  ? 596  SER A OG    1 ? 
ATOM   4314  O  OG    B SER A 1 596 ? -2.622  7.661   -1.394   0.5  25.29   ? 596  SER A OG    1 ? 
ATOM   4315  N  N     . GLU A 1 597 ? -0.829  6.893   -4.589   1    18.487  ? 597  GLU A N     1 ? 
ATOM   4316  C  CA    . GLU A 1 597 ? 0.035   6.357   -5.637   1    18.079  ? 597  GLU A CA    1 ? 
ATOM   4317  C  C     . GLU A 1 597 ? -0.346  4.968   -6.161   1    16.739  ? 597  GLU A C     1 ? 
ATOM   4318  O  O     . GLU A 1 597 ? -0.877  4.136   -5.455   1    18.323  ? 597  GLU A O     1 ? 
ATOM   4319  C  CB    . GLU A 1 597 ? 1.475   6.348   -5.08    1    17.28   ? 597  GLU A CB    1 ? 
ATOM   4320  C  CG    . GLU A 1 597 ? 2.002   7.77    -4.848   1    17.113  ? 597  GLU A CG    1 ? 
ATOM   4321  C  CD    . GLU A 1 597 ? 1.53    8.59    -3.641   1    19.752  ? 597  GLU A CD    1 ? 
ATOM   4322  O  OE1   . GLU A 1 597 ? 1.017   8.072   -2.612   1    20.556  ? 597  GLU A OE1   1 ? 
ATOM   4323  O  OE2   . GLU A 1 597 ? 1.773   9.808   -3.701   1    20.059  ? 597  GLU A OE2   1 ? 
ATOM   4324  N  N     . CYS A 1 598 ? 0.047   4.669   -7.398   1    15.223  ? 598  CYS A N     1 ? 
ATOM   4325  C  CA    . CYS A 1 598 ? 0.131   3.297   -7.878   1    17.183  ? 598  CYS A CA    1 ? 
ATOM   4326  C  C     . CYS A 1 598 ? 1.05    2.449   -6.989   1    17.896  ? 598  CYS A C     1 ? 
ATOM   4327  O  O     . CYS A 1 598 ? 2.098   2.951   -6.544   1    18.291  ? 598  CYS A O     1 ? 
ATOM   4328  C  CB    . CYS A 1 598 ? 0.718   3.358   -9.291   1    19.471  ? 598  CYS A CB    1 ? 
ATOM   4329  S  SG    . CYS A 1 598 ? 0.782   1.766   -10.165  1    22.669  ? 598  CYS A SG    1 ? 
ATOM   4330  N  N     . LEU A 1 599 ? 0.69    1.16    -6.779   1    16.514  ? 599  LEU A N     1 ? 
ATOM   4331  C  CA    . LEU A 1 599 ? 1.498   0.203   -6.026   1    19.194  ? 599  LEU A CA    1 ? 
ATOM   4332  C  C     . LEU A 1 599 ? 2.11    -0.829  -6.961   1    21.427  ? 599  LEU A C     1 ? 
ATOM   4333  O  O     . LEU A 1 599 ? 1.394   -1.379  -7.781   1    20.678  ? 599  LEU A O     1 ? 
ATOM   4334  C  CB    . LEU A 1 599 ? 0.608   -0.556  -5.051   1    19.351  ? 599  LEU A CB    1 ? 
ATOM   4335  C  CG    . LEU A 1 599 ? 0.149   0.251   -3.836   1    23.553  ? 599  LEU A CG    1 ? 
ATOM   4336  C  CD1   . LEU A 1 599 ? -0.93   -0.594  -3.162   1    26.644  ? 599  LEU A CD1   1 ? 
ATOM   4337  C  CD2   . LEU A 1 599 ? 1.31    0.53    -2.87    1    22.269  ? 599  LEU A CD2   1 ? 
ATOM   4338  N  N     . MET A 1 600 ? 3.375   -1.201  -6.746   1    21.414  ? 600  MET A N     1 ? 
ATOM   4339  C  CA    . MET A 1 600 ? 3.967   -2.323  -7.472   1    19.169  ? 600  MET A CA    1 ? 
ATOM   4340  C  C     . MET A 1 600 ? 4.312   -3.4    -6.437   1    20.483  ? 600  MET A C     1 ? 
ATOM   4341  O  O     . MET A 1 600 ? 5.018   -3.093  -5.473   1    20.302  ? 600  MET A O     1 ? 
ATOM   4342  C  CB    . MET A 1 600 ? 5.244   -1.819  -8.174   1    21.303  ? 600  MET A CB    1 ? 
ATOM   4343  C  CG    . MET A 1 600 ? 5.977   -2.827  -9.083   1    22.54   ? 600  MET A CG    1 ? 
ATOM   4344  S  SD    . MET A 1 600 ? 7.498   -2.193  -9.863   1    28.8    ? 600  MET A SD    1 ? 
ATOM   4345  C  CE    . MET A 1 600 ? 8.605   -2.387  -8.475   1    24.161  ? 600  MET A CE    1 ? 
ATOM   4346  N  N     . CYS A 1 601 ? 3.837   -4.646  -6.639   1    17.177  ? 601  CYS A N     1 ? 
ATOM   4347  C  CA    . CYS A 1 601 ? 3.822   -5.672  -5.612   1    17.414  ? 601  CYS A CA    1 ? 
ATOM   4348  C  C     . CYS A 1 601 ? 4.367   -6.952  -6.255   1    18.024  ? 601  CYS A C     1 ? 
ATOM   4349  O  O     . CYS A 1 601 ? 4.176   -7.166  -7.441   1    19.035  ? 601  CYS A O     1 ? 
ATOM   4350  C  CB    . CYS A 1 601 ? 2.38    -5.97   -5.183   1    18.813  ? 601  CYS A CB    1 ? 
ATOM   4351  S  SG    . CYS A 1 601 ? 1.513   -4.479  -4.584   1    23.567  ? 601  CYS A SG    1 ? 
ATOM   4352  N  N     . TRP A 1 602 ? 5.05    -7.804  -5.486   1    18.106  ? 602  TRP A N     1 ? 
ATOM   4353  C  CA    . TRP A 1 602 ? 5.554   -9.069  -6.02    1    17.123  ? 602  TRP A CA    1 ? 
ATOM   4354  C  C     . TRP A 1 602 ? 5.773   -10.038 -4.867   1    14.942  ? 602  TRP A C     1 ? 
ATOM   4355  O  O     . TRP A 1 602 ? 5.891   -9.612  -3.72    1    17.618  ? 602  TRP A O     1 ? 
ATOM   4356  C  CB    . TRP A 1 602 ? 6.821   -8.846  -6.874   1    19.317  ? 602  TRP A CB    1 ? 
ATOM   4357  C  CG    . TRP A 1 602 ? 7.998   -8.224  -6.138   1    21.44   ? 602  TRP A CG    1 ? 
ATOM   4358  C  CD1   . TRP A 1 602 ? 9.056   -8.891  -5.579   1    22.941  ? 602  TRP A CD1   1 ? 
ATOM   4359  C  CD2   . TRP A 1 602 ? 8.243   -6.817  -5.901   1    19.682  ? 602  TRP A CD2   1 ? 
ATOM   4360  N  NE1   . TRP A 1 602 ? 9.904   -8.015  -4.955   1    22.735  ? 602  TRP A NE1   1 ? 
ATOM   4361  C  CE2   . TRP A 1 602 ? 9.446   -6.728  -5.157   1    19.827  ? 602  TRP A CE2   1 ? 
ATOM   4362  C  CE3   . TRP A 1 602 ? 7.547   -5.632  -6.217   1    19.277  ? 602  TRP A CE3   1 ? 
ATOM   4363  C  CZ2   . TRP A 1 602 ? 9.99    -5.506  -4.755   1    20.138  ? 602  TRP A CZ2   1 ? 
ATOM   4364  C  CZ3   . TRP A 1 602 ? 8.098   -4.417  -5.853   1    19.904  ? 602  TRP A CZ3   1 ? 
ATOM   4365  C  CH2   . TRP A 1 602 ? 9.292   -4.361  -5.101   1    23.014  ? 602  TRP A CH2   1 ? 
ATOM   4366  N  N     . TYR A 1 603 ? 5.755   -11.339 -5.164   1    15.84   ? 603  TYR A N     1 ? 
ATOM   4367  C  CA    . TYR A 1 603 ? 6.076   -12.358 -4.176   1    15.612  ? 603  TYR A CA    1 ? 
ATOM   4368  C  C     . TYR A 1 603 ? 7.559   -12.222 -3.837   1    17.79   ? 603  TYR A C     1 ? 
ATOM   4369  O  O     . TYR A 1 603 ? 8.388   -12.119 -4.728   1    17.672  ? 603  TYR A O     1 ? 
ATOM   4370  C  CB    . TYR A 1 603 ? 5.929   -13.738 -4.817   1    17.436  ? 603  TYR A CB    1 ? 
ATOM   4371  C  CG    . TYR A 1 603 ? 6.382   -14.936 -4.002   1    20.741  ? 603  TYR A CG    1 ? 
ATOM   4372  C  CD1   . TYR A 1 603 ? 5.634   -15.35  -2.93    1    20.995  ? 603  TYR A CD1   1 ? 
ATOM   4373  C  CD2   . TYR A 1 603 ? 7.624   -15.551 -4.211   1    26.409  ? 603  TYR A CD2   1 ? 
ATOM   4374  C  CE1   . TYR A 1 603 ? 6.03    -16.411 -2.135   1    29.45   ? 603  TYR A CE1   1 ? 
ATOM   4375  C  CE2   . TYR A 1 603 ? 8.042   -16.609 -3.404   1    26.088  ? 603  TYR A CE2   1 ? 
ATOM   4376  C  CZ    . TYR A 1 603 ? 7.229   -17.05  -2.383   1    28.649  ? 603  TYR A CZ    1 ? 
ATOM   4377  O  OH    . TYR A 1 603 ? 7.502   -18.06  -1.508   1    39.462  ? 603  TYR A OH    1 ? 
ATOM   4378  N  N     . ASP A 1 604 ? 7.881   -12.279 -2.55    1    18.693  ? 604  ASP A N     1 ? 
ATOM   4379  C  CA    . ASP A 1 604 ? 9.286   -12.366 -2.175   1    20.408  ? 604  ASP A CA    1 ? 
ATOM   4380  C  C     . ASP A 1 604 ? 9.465   -13.493 -1.141   1    23.776  ? 604  ASP A C     1 ? 
ATOM   4381  O  O     . ASP A 1 604 ? 8.832   -13.495 -0.083   1    22.143  ? 604  ASP A O     1 ? 
ATOM   4382  C  CB    . ASP A 1 604 ? 9.688   -11.078 -1.499   1    21.389  ? 604  ASP A CB    1 ? 
ATOM   4383  C  CG    . ASP A 1 604 ? 11.145  -11.054 -1.047   1    29.732  ? 604  ASP A CG    1 ? 
ATOM   4384  O  OD1   . ASP A 1 604 ? 12.022  -11.033 -1.926   1    33.277  ? 604  ASP A OD1   1 ? 
ATOM   4385  O  OD2   . ASP A 1 604 ? 11.375  -11.084 0.168    1    27.268  ? 604  ASP A OD2   1 ? 
ATOM   4386  N  N     . ARG A 1 605 ? 10.388  -14.418 -1.397   1    28.854  ? 605  ARG A N     1 ? 
ATOM   4387  C  CA    . ARG A 1 605 ? 10.527  -15.593 -0.532   1    35.635  ? 605  ARG A CA    1 ? 
ATOM   4388  C  C     . ARG A 1 605 ? 10.994  -15.264 0.891    1    33.513  ? 605  ARG A C     1 ? 
ATOM   4389  O  O     . ARG A 1 605 ? 10.696  -16.003 1.834    1    39.252  ? 605  ARG A O     1 ? 
ATOM   4390  C  CB    . ARG A 1 605 ? 11.479  -16.587 -1.213   1    47.387  ? 605  ARG A CB    1 ? 
ATOM   4391  C  CG    . ARG A 1 605 ? 12.892  -16.089 -1.501   1    66.707  ? 605  ARG A CG    1 ? 
ATOM   4392  C  CD    . ARG A 1 605 ? 13.835  -17.204 -1.984   1    79.111  ? 605  ARG A CD    1 ? 
ATOM   4393  N  NE    . ARG A 1 605 ? 15.245  -16.852 -1.774   1    74.458  ? 605  ARG A NE    1 ? 
ATOM   4394  C  CZ    . ARG A 1 605 ? 15.981  -15.992 -2.482   1    82.829  ? 605  ARG A CZ    1 ? 
ATOM   4395  N  NH1   . ARG A 1 605 ? 15.492  -15.403 -3.565   1    72.538  ? 605  ARG A NH1   1 ? 
ATOM   4396  N  NH2   . ARG A 1 605 ? 17.223  -15.736 -2.103   1    84.427  ? 605  ARG A NH2   1 ? 
ATOM   4397  N  N     . ASP A 1 606 ? 11.735  -14.166 1.074    1    32.006  ? 606  ASP A N     1 ? 
ATOM   4398  C  CA    . ASP A 1 606 ? 12.233  -13.816 2.404    1    29.812  ? 606  ASP A CA    1 ? 
ATOM   4399  C  C     . ASP A 1 606 ? 11.214  -13.01  3.209    1    29.883  ? 606  ASP A C     1 ? 
ATOM   4400  O  O     . ASP A 1 606 ? 11.529  -12.583 4.309    1    31.182  ? 606  ASP A O     1 ? 
ATOM   4401  C  CB    . ASP A 1 606 ? 13.547  -13.062 2.284    1    32.418  ? 606  ASP A CB    1 ? 
ATOM   4402  C  CG    . ASP A 1 606 ? 14.667  -13.9   1.676    1    39.524  ? 606  ASP A CG    1 ? 
ATOM   4403  O  OD1   . ASP A 1 606 ? 14.943  -14.97  2.237    1    37.184  ? 606  ASP A OD1   1 ? 
ATOM   4404  O  OD2   . ASP A 1 606 ? 15.215  -13.504 0.623    1    45.583  ? 606  ASP A OD2   1 ? 
ATOM   4405  N  N     . THR A 1 607 ? 9.988   -12.819 2.694    1    28.755  ? 607  THR A N     1 ? 
ATOM   4406  C  CA    . THR A 1 607 ? 9.023   -11.943 3.361    1    24.705  ? 607  THR A CA    1 ? 
ATOM   4407  C  C     . THR A 1 607 ? 7.979   -12.761 4.125    1    23.037  ? 607  THR A C     1 ? 
ATOM   4408  O  O     . THR A 1 607 ? 7.38    -13.656 3.55     1    24.953  ? 607  THR A O     1 ? 
ATOM   4409  C  CB    . THR A 1 607 ? 8.381   -11.014 2.321    1    25.223  ? 607  THR A CB    1 ? 
ATOM   4410  O  OG1   . THR A 1 607 ? 9.381   -10.171 1.743    1    22.418  ? 607  THR A OG1   1 ? 
ATOM   4411  C  CG2   . THR A 1 607 ? 7.307   -10.108 2.911    1    23.324  ? 607  THR A CG2   1 ? 
ATOM   4412  N  N     . GLU A 1 608 ? 7.675   -12.397 5.383    1    21.496  ? 608  GLU A N     1 ? 
ATOM   4413  C  CA    . GLU A 1 608 ? 6.53    -13.01  6.024    1    24.674  ? 608  GLU A CA    1 ? 
ATOM   4414  C  C     . GLU A 1 608 ? 5.986   -12.094 7.112    1    26.976  ? 608  GLU A C     1 ? 
ATOM   4415  O  O     . GLU A 1 608 ? 6.712   -11.754 8.029    1    25.563  ? 608  GLU A O     1 ? 
ATOM   4416  C  CB    . GLU A 1 608 ? 6.897   -14.334 6.698    1    30.817  ? 608  GLU A CB    1 ? 
ATOM   4417  C  CG    . GLU A 1 608 ? 5.67    -15.032 7.302    1    34.162  ? 608  GLU A CG    1 ? 
ATOM   4418  C  CD    . GLU A 1 608 ? 5.955   -16.365 8.021    1    44.374  ? 608  GLU A CD    1 ? 
ATOM   4419  O  OE1   . GLU A 1 608 ? 6.608   -17.25  7.408    1    46.31   ? 608  GLU A OE1   1 ? 
ATOM   4420  O  OE2   . GLU A 1 608 ? 5.526   -16.54  9.198    1    39.912  ? 608  GLU A OE2   1 ? 
ATOM   4421  N  N     . PHE A 1 609 ? 4.693   -11.726 7.034    1    25.031  ? 609  PHE A N     1 ? 
ATOM   4422  C  CA    . PHE A 1 609 ? 4.12    -10.854 8.043    1    25.148  ? 609  PHE A CA    1 ? 
ATOM   4423  C  C     . PHE A 1 609 ? 2.609   -11.028 8.003    1    25.617  ? 609  PHE A C     1 ? 
ATOM   4424  O  O     . PHE A 1 609 ? 2.084   -11.602 7.065    1    28.135  ? 609  PHE A O     1 ? 
ATOM   4425  C  CB    . PHE A 1 609 ? 4.558   -9.397  7.805    1    26.464  ? 609  PHE A CB    1 ? 
ATOM   4426  C  CG    . PHE A 1 609 ? 4.024   -8.774  6.516    1    28.731  ? 609  PHE A CG    1 ? 
ATOM   4427  C  CD1   . PHE A 1 609 ? 4.723   -8.885  5.318    1    27.931  ? 609  PHE A CD1   1 ? 
ATOM   4428  C  CD2   . PHE A 1 609 ? 2.786   -8.116  6.498    1    26.339  ? 609  PHE A CD2   1 ? 
ATOM   4429  C  CE1   . PHE A 1 609 ? 4.208   -8.346  4.139    1    27.969  ? 609  PHE A CE1   1 ? 
ATOM   4430  C  CE2   . PHE A 1 609 ? 2.29    -7.545  5.329    1    24.387  ? 609  PHE A CE2   1 ? 
ATOM   4431  C  CZ    . PHE A 1 609 ? 2.99    -7.686  4.143    1    23.98   ? 609  PHE A CZ    1 ? 
ATOM   4432  N  N     . ILE A 1 610 ? 1.914   -10.522 9.018    1    27.377  ? 610  ILE A N     1 ? 
ATOM   4433  C  CA    . ILE A 1 610 ? 0.465   -10.66  9.083    1    28.18   ? 610  ILE A CA    1 ? 
ATOM   4434  C  C     . ILE A 1 610 ? -0.152  -9.455  8.372    1    25.348  ? 610  ILE A C     1 ? 
ATOM   4435  O  O     . ILE A 1 610 ? 0.052   -8.327  8.78     1    27.372  ? 610  ILE A O     1 ? 
ATOM   4436  C  CB    . ILE A 1 610 ? -0.031  -10.784 10.532   1    29.127  ? 610  ILE A CB    1 ? 
ATOM   4437  C  CG1   . ILE A 1 610 ? 0.569   -12.024 11.226   1    28.936  ? 610  ILE A CG1   1 ? 
ATOM   4438  C  CG2   . ILE A 1 610 ? -1.571  -10.798 10.583   1    30.753  ? 610  ILE A CG2   1 ? 
ATOM   4439  C  CD1   . ILE A 1 610 ? -0.037  -12.299 12.593   1    36.702  ? 610  ILE A CD1   1 ? 
ATOM   4440  N  N     . TYR A 1 611 ? -0.837  -9.706  7.259    1    27.822  ? 611  TYR A N     1 ? 
ATOM   4441  C  CA    . TYR A 1 611 ? -1.611  -8.664  6.595    1    29.533  ? 611  TYR A CA    1 ? 
ATOM   4442  C  C     . TYR A 1 611 ? -3.028  -8.668  7.163    1    27.686  ? 611  TYR A C     1 ? 
ATOM   4443  O  O     . TYR A 1 611 ? -3.762  -9.631  7.003    1    24.011  ? 611  TYR A O     1 ? 
ATOM   4444  C  CB    . TYR A 1 611 ? -1.701  -8.886  5.08     1    26.647  ? 611  TYR A CB    1 ? 
ATOM   4445  C  CG    . TYR A 1 611 ? -2.284  -7.734  4.272    1    25.529  ? 611  TYR A CG    1 ? 
ATOM   4446  C  CD1   . TYR A 1 611 ? -3.672  -7.54   4.15     1    22.811  ? 611  TYR A CD1   1 ? 
ATOM   4447  C  CD2   . TYR A 1 611 ? -1.426  -6.831  3.641    1    24.374  ? 611  TYR A CD2   1 ? 
ATOM   4448  C  CE1   . TYR A 1 611 ? -4.185  -6.504  3.365    1    25.592  ? 611  TYR A CE1   1 ? 
ATOM   4449  C  CE2   . TYR A 1 611 ? -1.927  -5.796  2.87     1    27.948  ? 611  TYR A CE2   1 ? 
ATOM   4450  C  CZ    . TYR A 1 611 ? -3.305  -5.627  2.734    1    25.393  ? 611  TYR A CZ    1 ? 
ATOM   4451  O  OH    . TYR A 1 611 ? -3.714  -4.555  2        1    23.617  ? 611  TYR A OH    1 ? 
ATOM   4452  N  N     . PRO A 1 612 ? -3.485  -7.565  7.781    1    27.606  ? 612  PRO A N     1 ? 
ATOM   4453  C  CA    . PRO A 1 612 ? -4.831  -7.534  8.338    1    27.107  ? 612  PRO A CA    1 ? 
ATOM   4454  C  C     . PRO A 1 612 ? -5.959  -7.568  7.302    1    25.016  ? 612  PRO A C     1 ? 
ATOM   4455  O  O     . PRO A 1 612 ? -5.812  -7.167  6.15     1    21.27   ? 612  PRO A O     1 ? 
ATOM   4456  C  CB    . PRO A 1 612 ? -4.812  -6.284  9.238    1    28.75   ? 612  PRO A CB    1 ? 
ATOM   4457  C  CG    . PRO A 1 612 ? -3.865  -5.372  8.462    1    37.119  ? 612  PRO A CG    1 ? 
ATOM   4458  C  CD    . PRO A 1 612 ? -2.723  -6.32   7.998    1    30.528  ? 612  PRO A CD    1 ? 
ATOM   4459  N  N     . SER A 1 613 ? -7.026  -8.267  7.684    1    24.263  ? 613  SER A N     1 ? 
ATOM   4460  C  CA    . SER A 1 613 ? -8.291  -8.238  6.971    1    24.98   ? 613  SER A CA    1 ? 
ATOM   4461  C  C     . SER A 1 613 ? -8.802  -6.8    6.911    1    24.653  ? 613  SER A C     1 ? 
ATOM   4462  O  O     . SER A 1 613 ? -8.803  -6.079  7.909    1    26.444  ? 613  SER A O     1 ? 
ATOM   4463  C  CB    . SER A 1 613 ? -9.296  -9.034  7.726    1    24.856  ? 613  SER A CB    1 ? 
ATOM   4464  O  OG    . SER A 1 613 ? -10.464 -9.174  6.921    1    26.133  ? 613  SER A OG    1 ? 
ATOM   4465  N  N     . PRO A 1 614 ? -9.265  -6.336  5.738    1    22.679  ? 614  PRO A N     1 ? 
ATOM   4466  C  CA    . PRO A 1 614 ? -9.915  -5.017  5.646    1    25.066  ? 614  PRO A CA    1 ? 
ATOM   4467  C  C     . PRO A 1 614 ? -11.359 -5.114  6.169    1    28.474  ? 614  PRO A C     1 ? 
ATOM   4468  O  O     . PRO A 1 614 ? -12.061 -4.118  6.266    1    29.623  ? 614  PRO A O     1 ? 
ATOM   4469  C  CB    . PRO A 1 614 ? -9.878  -4.812  4.105    1    23.598  ? 614  PRO A CB    1 ? 
ATOM   4470  C  CG    . PRO A 1 614 ? -10.044 -6.205  3.541    1    21.319  ? 614  PRO A CG    1 ? 
ATOM   4471  C  CD    . PRO A 1 614 ? -9.257  -7.105  4.495    1    20.935  ? 614  PRO A CD    1 ? 
ATOM   4472  N  N     . TRP A 1 615 ? -11.851 -6.339  6.424    1    31.439  ? 615  TRP A N     1 ? 
ATOM   4473  C  CA    . TRP A 1 615 ? -13.195 -6.524  6.968    1    28.665  ? 615  TRP A CA    1 ? 
ATOM   4474  C  C     . TRP A 1 615 ? -13.222 -7.811  7.798    1    25.693  ? 615  TRP A C     1 ? 
ATOM   4475  O  O     . TRP A 1 615 ? -13.529 -8.885  7.291    1    26.187  ? 615  TRP A O     1 ? 
ATOM   4476  C  CB    . TRP A 1 615 ? -14.236 -6.55   5.839    1    29.291  ? 615  TRP A CB    1 ? 
ATOM   4477  C  CG    . TRP A 1 615 ? -15.672 -6.427  6.286    1    33.517  ? 615  TRP A CG    1 ? 
ATOM   4478  C  CD1   . TRP A 1 615 ? -16.162 -6.463  7.564    1    34.744  ? 615  TRP A CD1   1 ? 
ATOM   4479  C  CD2   . TRP A 1 615 ? -16.825 -6.269  5.42     1    28.26   ? 615  TRP A CD2   1 ? 
ATOM   4480  N  NE1   . TRP A 1 615 ? -17.527 -6.308  7.553    1    34.325  ? 615  TRP A NE1   1 ? 
ATOM   4481  C  CE2   . TRP A 1 615 ? -17.966 -6.196  6.259    1    32.36   ? 615  TRP A CE2   1 ? 
ATOM   4482  C  CE3   . TRP A 1 615 ? -17.007 -6.166  4.029    1    22.735  ? 615  TRP A CE3   1 ? 
ATOM   4483  C  CZ2   . TRP A 1 615 ? -19.26  -6.03   5.748    1    28.556  ? 615  TRP A CZ2   1 ? 
ATOM   4484  C  CZ3   . TRP A 1 615 ? -18.284 -5.996  3.531    1    22.984  ? 615  TRP A CZ3   1 ? 
ATOM   4485  C  CH2   . TRP A 1 615 ? -19.407 -5.958  4.374    1    22.624  ? 615  TRP A CH2   1 ? 
ATOM   4486  N  N     . PRO A 1 616 ? -12.76  -7.764  9.067    1    25.147  ? 616  PRO A N     1 ? 
ATOM   4487  C  CA    . PRO A 1 616 ? -12.542 -8.983  9.861    1    29.533  ? 616  PRO A CA    1 ? 
ATOM   4488  C  C     . PRO A 1 616 ? -13.721 -9.951  9.935    1    27.443  ? 616  PRO A C     1 ? 
ATOM   4489  O  O     . PRO A 1 616 ? -13.56  -11.163 9.827    1    26.768  ? 616  PRO A O     1 ? 
ATOM   4490  C  CB    . PRO A 1 616 ? -12.122 -8.449  11.235   1    25.913  ? 616  PRO A CB    1 ? 
ATOM   4491  C  CG    . PRO A 1 616 ? -11.464 -7.147  10.905   1    28.381  ? 616  PRO A CG    1 ? 
ATOM   4492  C  CD    . PRO A 1 616 ? -12.272 -6.553  9.74     1    24.855  ? 616  PRO A CD    1 ? 
ATOM   4493  N  N     . GLU A 1 617 ? -14.924 -9.406  10.058   1    33.565  ? 617  GLU A N     1 ? 
ATOM   4494  C  CA    . GLU A 1 617 ? -16.102 -10.244 10.188   1    33.834  ? 617  GLU A CA    1 ? 
ATOM   4495  C  C     . GLU A 1 617 ? -16.343 -11.043 8.914    1    38.885  ? 617  GLU A C     1 ? 
ATOM   4496  O  O     . GLU A 1 617 ? -16.986 -12.083 8.972    1    35.015  ? 617  GLU A O     1 ? 
ATOM   4497  C  CB    . GLU A 1 617 ? -17.321 -9.426  10.595   1    38.732  ? 617  GLU A CB    1 ? 
ATOM   4498  C  CG    . GLU A 1 617 ? -17.09  -8.558  11.832   1    44.236  ? 617  GLU A CG    1 ? 
ATOM   4499  C  CD    . GLU A 1 617 ? -16.385 -7.21   11.715   1    57.21   ? 617  GLU A CD    1 ? 
ATOM   4500  O  OE1   . GLU A 1 617 ? -15.572 -6.925  10.796   1    53.459  ? 617  GLU A OE1   1 ? 
ATOM   4501  O  OE2   . GLU A 1 617 ? -16.697 -6.4    12.615   1    63.935  ? 617  GLU A OE2   1 ? 
ATOM   4502  N  N     . LYS A 1 618 ? -15.817 -10.583 7.764    1    35.188  ? 618  LYS A N     1 ? 
ATOM   4503  C  CA    . LYS A 1 618 ? -16.175 -11.254 6.534    1    32.646  ? 618  LYS A CA    1 ? 
ATOM   4504  C  C     . LYS A 1 618 ? -15.006 -11.939 5.844    1    31.356  ? 618  LYS A C     1 ? 
ATOM   4505  O  O     . LYS A 1 618 ? -15.274 -12.821 5.035    1    32.054  ? 618  LYS A O     1 ? 
ATOM   4506  C  CB    . LYS A 1 618 ? -16.763 -10.313 5.473    1    34.953  ? 618  LYS A CB    1 ? 
ATOM   4507  C  CG    . LYS A 1 618 ? -17.934 -9.486  5.98     1    37.21   ? 618  LYS A CG    1 ? 
ATOM   4508  C  CD    . LYS A 1 618 ? -19.211 -10.213 6.381    1    38.767  ? 618  LYS A CD    1 ? 
ATOM   4509  C  CE    . LYS A 1 618 ? -20.221 -9.202  6.913    1    44.102  ? 618  LYS A CE    1 ? 
ATOM   4510  N  NZ    . LYS A 1 618 ? -21.424 -9.845  7.442    1    44.645  ? 618  LYS A NZ    1 ? 
ATOM   4511  N  N     . PHE A 1 619 ? -13.759 -11.446 6.005    1    29.804  ? 619  PHE A N     1 ? 
ATOM   4512  C  CA    . PHE A 1 619 ? -12.655 -12.076 5.281    1    28.825  ? 619  PHE A CA    1 ? 
ATOM   4513  C  C     . PHE A 1 619 ? -11.479 -12.295 6.237    1    24.081  ? 619  PHE A C     1 ? 
ATOM   4514  O  O     . PHE A 1 619 ? -11.2   -11.447 7.08     1    24.898  ? 619  PHE A O     1 ? 
ATOM   4515  C  CB    . PHE A 1 619 ? -12.098 -11.203 4.136    1    28.258  ? 619  PHE A CB    1 ? 
ATOM   4516  C  CG    . PHE A 1 619 ? -13.149 -10.858 3.096    1    28.743  ? 619  PHE A CG    1 ? 
ATOM   4517  C  CD1   . PHE A 1 619 ? -13.398 -11.726 2.045    1    29.105  ? 619  PHE A CD1   1 ? 
ATOM   4518  C  CD2   . PHE A 1 619 ? -13.891 -9.68   3.189    1    25.312  ? 619  PHE A CD2   1 ? 
ATOM   4519  C  CE1   . PHE A 1 619 ? -14.373 -11.446 1.114    1    26.398  ? 619  PHE A CE1   1 ? 
ATOM   4520  C  CE2   . PHE A 1 619 ? -14.839 -9.376  2.226    1    25.791  ? 619  PHE A CE2   1 ? 
ATOM   4521  C  CZ    . PHE A 1 619 ? -15.103 -10.275 1.203    1    26.255  ? 619  PHE A CZ    1 ? 
ATOM   4522  N  N     . PRO A 1 620 ? -10.704 -13.395 6.116    1    25.125  ? 620  PRO A N     1 ? 
ATOM   4523  C  CA    . PRO A 1 620 ? -9.672  -13.684 7.111    1    24.451  ? 620  PRO A CA    1 ? 
ATOM   4524  C  C     . PRO A 1 620 ? -8.437  -12.827 6.827    1    25.156  ? 620  PRO A C     1 ? 
ATOM   4525  O  O     . PRO A 1 620 ? -8.183  -12.465 5.69     1    23.869  ? 620  PRO A O     1 ? 
ATOM   4526  C  CB    . PRO A 1 620 ? -9.445  -15.206 6.87     1    27.727  ? 620  PRO A CB    1 ? 
ATOM   4527  C  CG    . PRO A 1 620 ? -9.617  -15.369 5.341    1    27.413  ? 620  PRO A CG    1 ? 
ATOM   4528  C  CD    . PRO A 1 620 ? -10.844 -14.454 5.1      1    26.718  ? 620  PRO A CD    1 ? 
ATOM   4529  N  N     . ALA A 1 621 ? -7.696  -12.49  7.878    1    25.053  ? 621  ALA A N     1 ? 
ATOM   4530  C  CA    . ALA A 1 621 ? -6.33   -11.985 7.803    1    26.428  ? 621  ALA A CA    1 ? 
ATOM   4531  C  C     . ALA A 1 621 ? -5.45   -12.917 6.969    1    27.063  ? 621  ALA A C     1 ? 
ATOM   4532  O  O     . ALA A 1 621 ? -5.755  -14.092 6.804    1    26.853  ? 621  ALA A O     1 ? 
ATOM   4533  C  CB    . ALA A 1 621 ? -5.832  -11.895 9.224    1    28.698  ? 621  ALA A CB    1 ? 
ATOM   4534  N  N     . ILE A 1 622 ? -4.385  -12.371 6.385    1    26.88   ? 622  ILE A N     1 ? 
ATOM   4535  C  CA    . ILE A 1 622 ? -3.379  -13.163 5.687    1    26.238  ? 622  ILE A CA    1 ? 
ATOM   4536  C  C     . ILE A 1 622 ? -2.276  -13.423 6.711    1    26.281  ? 622  ILE A C     1 ? 
ATOM   4537  O  O     . ILE A 1 622 ? -1.514  -12.522 7.065    1    26.415  ? 622  ILE A O     1 ? 
ATOM   4538  C  CB    . ILE A 1 622 ? -2.817  -12.484 4.41     1    23.834  ? 622  ILE A CB    1 ? 
ATOM   4539  C  CG1   . ILE A 1 622 ? -3.917  -11.852 3.562    1    26.271  ? 622  ILE A CG1   1 ? 
ATOM   4540  C  CG2   . ILE A 1 622 ? -1.981  -13.46  3.559    1    20.82   ? 622  ILE A CG2   1 ? 
ATOM   4541  C  CD1   . ILE A 1 622 ? -3.369  -11.012 2.435    1    25.634  ? 622  ILE A CD1   1 ? 
ATOM   4542  N  N     . GLU A 1 623 ? -2.253  -14.653 7.226    1    26.461  ? 623  GLU A N     1 ? 
ATOM   4543  C  CA    . GLU A 1 623 ? -1.333  -15.015 8.304    1    31.094  ? 623  GLU A CA    1 ? 
ATOM   4544  C  C     . GLU A 1 623 ? 0.117   -14.958 7.827    1    25.873  ? 623  GLU A C     1 ? 
ATOM   4545  O  O     . GLU A 1 623 ? 0.993   -14.483 8.542    1    26.801  ? 623  GLU A O     1 ? 
ATOM   4546  C  CB    . GLU A 1 623 ? -1.678  -16.387 8.902    1    32.328  ? 623  GLU A CB    1 ? 
ATOM   4547  C  CG    . GLU A 1 623 ? -2.856  -16.344 9.875    1    51.173  ? 623  GLU A CG    1 ? 
ATOM   4548  C  CD    . GLU A 1 623 ? -2.715  -15.374 11.048   1    64.386  ? 623  GLU A CD    1 ? 
ATOM   4549  O  OE1   . GLU A 1 623 ? -1.761  -15.541 11.846   1    77.945  ? 623  GLU A OE1   1 ? 
ATOM   4550  O  OE2   . GLU A 1 623 ? -3.55   -14.444 11.174   1    63.338  ? 623  GLU A OE2   1 ? 
ATOM   4551  N  N     . ARG A 1 624 ? 0.378   -15.429 6.604    1    23.038  ? 624  ARG A N     1 ? 
ATOM   4552  C  CA    . ARG A 1 624 ? 1.742   -15.384 6.106    1    25.795  ? 624  ARG A CA    1 ? 
ATOM   4553  C  C     . ARG A 1 624 ? 1.751   -14.657 4.767    1    23.349  ? 624  ARG A C     1 ? 
ATOM   4554  O  O     . ARG A 1 624 ? 1.784   -15.269 3.697    1    21.643  ? 624  ARG A O     1 ? 
ATOM   4555  C  CB    . ARG A 1 624 ? 2.336   -16.799 5.984    1    26.264  ? 624  ARG A CB    1 ? 
ATOM   4556  C  CG    . ARG A 1 624 ? 2.311   -17.514 7.336    1    32.668  ? 624  ARG A CG    1 ? 
ATOM   4557  C  CD    . ARG A 1 624 ? 2.904   -18.931 7.186    1    40.669  ? 624  ARG A CD    1 ? 
ATOM   4558  N  NE    . ARG A 1 624 ? 3.528   -19.462 8.405    1    38.489  ? 624  ARG A NE    1 ? 
ATOM   4559  C  CZ    . ARG A 1 624 ? 4.524   -20.383 8.477    1    46.266  ? 624  ARG A CZ    1 ? 
ATOM   4560  N  NH1   . ARG A 1 624 ? 5.092   -20.942 7.407    1    34.819  ? 624  ARG A NH1   1 ? 
ATOM   4561  N  NH2   . ARG A 1 624 ? 4.973   -20.729 9.667    1    42.083  ? 624  ARG A NH2   1 ? 
ATOM   4562  N  N     . CYS A 1 625 ? 1.702   -13.336 4.849    1    23.606  ? 625  CYS A N     1 ? 
ATOM   4563  C  CA    . CYS A 1 625 ? 1.736   -12.554 3.638    1    20.31   ? 625  CYS A CA    1 ? 
ATOM   4564  C  C     . CYS A 1 625 ? 3.19    -12.453 3.148    1    20.929  ? 625  CYS A C     1 ? 
ATOM   4565  O  O     . CYS A 1 625 ? 4.095   -12.272 3.957    1    19.688  ? 625  CYS A O     1 ? 
ATOM   4566  C  CB    . CYS A 1 625 ? 1.037   -11.227 3.92     1    22.311  ? 625  CYS A CB    1 ? 
ATOM   4567  S  SG    . CYS A 1 625 ? 1.08    -10.159 2.47     1    23.005  ? 625  CYS A SG    1 ? 
ATOM   4568  N  N     . CYS A 1 626 ? 3.409   -12.591 1.826    1    18.43   ? 626  CYS A N     1 ? 
ATOM   4569  C  CA    . CYS A 1 626 ? 4.748   -12.709 1.274    1    23.861  ? 626  CYS A CA    1 ? 
ATOM   4570  C  C     . CYS A 1 626 ? 5.002   -11.576 0.275    1    25.636  ? 626  CYS A C     1 ? 
ATOM   4571  O  O     . CYS A 1 626 ? 5.918   -11.68  -0.542   1    22.778  ? 626  CYS A O     1 ? 
ATOM   4572  C  CB    . CYS A 1 626 ? 4.892   -13.952 0.412    1    27.884  ? 626  CYS A CB    1 ? 
ATOM   4573  S  SG    . CYS A 1 626 ? 4.508   -15.491 1.29     1    33.065  ? 626  CYS A SG    1 ? 
ATOM   4574  N  N     . THR A 1 627 ? 4.156   -10.525 0.314    1    22.541  ? 627  THR A N     1 ? 
ATOM   4575  C  CA    . THR A 1 627 ? 4.229   -9.451  -0.668   1    19.612  ? 627  THR A CA    1 ? 
ATOM   4576  C  C     . THR A 1 627 ? 5.318   -8.459  -0.28    1    18.61   ? 627  THR A C     1 ? 
ATOM   4577  O  O     . THR A 1 627 ? 5.322   -7.931  0.827    1    20.621  ? 627  THR A O     1 ? 
ATOM   4578  C  CB    . THR A 1 627 ? 2.905   -8.692  -0.705   1    23.255  ? 627  THR A CB    1 ? 
ATOM   4579  O  OG1   . THR A 1 627 ? 1.915   -9.677  -1.023   1    23.056  ? 627  THR A OG1   1 ? 
ATOM   4580  C  CG2   . THR A 1 627 ? 2.937   -7.572  -1.737   1    20.313  ? 627  THR A CG2   1 ? 
ATOM   4581  N  N     . ARG A 1 628 ? 6.197   -8.156  -1.219   1    20.46   ? 628  ARG A N     1 ? 
ATOM   4582  C  CA    . ARG A 1 628 ? 7.073   -6.992  -1.109   1    23.157  ? 628  ARG A CA    1 ? 
ATOM   4583  C  C     . ARG A 1 628 ? 6.554   -5.974  -2.121   1    22.132  ? 628  ARG A C     1 ? 
ATOM   4584  O  O     . ARG A 1 628 ? 5.925   -6.372  -3.078   1    19.594  ? 628  ARG A O     1 ? 
ATOM   4585  C  CB    . ARG A 1 628 ? 8.51    -7.429  -1.438   1    27.455  ? 628  ARG A CB    1 ? 
ATOM   4586  C  CG    . ARG A 1 628 ? 9.607   -6.43   -1.12    1    30.483  ? 628  ARG A CG    1 ? 
ATOM   4587  C  CD    . ARG A 1 628 ? 10.926  -7.123  -0.861   1    37.437  ? 628  ARG A CD    1 ? 
ATOM   4588  N  NE    . ARG A 1 628 ? 11.955  -6.096  -0.632   1    35.244  ? 628  ARG A NE    1 ? 
ATOM   4589  C  CZ    . ARG A 1 628 ? 12.198  -5.516  0.551    1    35.354  ? 628  ARG A CZ    1 ? 
ATOM   4590  N  NH1   . ARG A 1 628 ? 11.611  -5.93   1.668    1    32.605  ? 628  ARG A NH1   1 ? 
ATOM   4591  N  NH2   . ARG A 1 628 ? 13.069  -4.533  0.628    1    38.746  ? 628  ARG A NH2   1 ? 
ATOM   4592  N  N     . TYR A 1 629 ? 6.768   -4.669  -1.908   1    21.483  ? 629  TYR A N     1 ? 
ATOM   4593  C  CA    . TYR A 1 629 ? 6.064   -3.704  -2.739   1    20.4    ? 629  TYR A CA    1 ? 
ATOM   4594  C  C     . TYR A 1 629 ? 6.867   -2.411  -2.796   1    21.035  ? 629  TYR A C     1 ? 
ATOM   4595  O  O     . TYR A 1 629 ? 7.757   -2.192  -1.983   1    18.273  ? 629  TYR A O     1 ? 
ATOM   4596  C  CB    . TYR A 1 629 ? 4.616   -3.434  -2.282   1    18.005  ? 629  TYR A CB    1 ? 
ATOM   4597  C  CG    . TYR A 1 629 ? 4.533   -2.721  -0.95    1    19.758  ? 629  TYR A CG    1 ? 
ATOM   4598  C  CD1   . TYR A 1 629 ? 4.529   -3.437  0.244    1    22.251  ? 629  TYR A CD1   1 ? 
ATOM   4599  C  CD2   . TYR A 1 629 ? 4.436   -1.323  -0.879   1    22.445  ? 629  TYR A CD2   1 ? 
ATOM   4600  C  CE1   . TYR A 1 629 ? 4.486   -2.791  1.473    1    25.119  ? 629  TYR A CE1   1 ? 
ATOM   4601  C  CE2   . TYR A 1 629 ? 4.379   -0.668  0.347    1    19.412  ? 629  TYR A CE2   1 ? 
ATOM   4602  C  CZ    . TYR A 1 629 ? 4.384   -1.402  1.523    1    26.169  ? 629  TYR A CZ    1 ? 
ATOM   4603  O  OH    . TYR A 1 629 ? 4.378   -0.762  2.742    1    26.713  ? 629  TYR A OH    1 ? 
ATOM   4604  N  N     . LYS A 1 630 ? 6.537   -1.579  -3.784   1    18.553  ? 630  LYS A N     1 ? 
ATOM   4605  C  CA    A LYS A 1 630 ? 7.089   -0.242  -3.9     0.5  19.816  ? 630  LYS A CA    1 ? 
ATOM   4606  C  CA    B LYS A 1 630 ? 7.092   -0.242  -3.911   0.5  18.459  ? 630  LYS A CA    1 ? 
ATOM   4607  C  C     . LYS A 1 630 ? 5.948   0.707   -4.254   1    17.814  ? 630  LYS A C     1 ? 
ATOM   4608  O  O     . LYS A 1 630 ? 5.138   0.412   -5.13    1    17.318  ? 630  LYS A O     1 ? 
ATOM   4609  C  CB    A LYS A 1 630 ? 8.105   -0.226  -5.048   0.5  19.787  ? 630  LYS A CB    1 ? 
ATOM   4610  C  CB    B LYS A 1 630 ? 8.07    -0.194  -5.091   0.5  16.2    ? 630  LYS A CB    1 ? 
ATOM   4611  C  CG    A LYS A 1 630 ? 8.857   1.07    -5.21    0.5  23.13   ? 630  LYS A CG    1 ? 
ATOM   4612  C  CG    B LYS A 1 630 ? 8.688   1.162   -5.347   0.5  16.293  ? 630  LYS A CG    1 ? 
ATOM   4613  C  CD    A LYS A 1 630 ? 9.946   0.966   -6.276   0.5  23.463  ? 630  LYS A CD    1 ? 
ATOM   4614  C  CD    B LYS A 1 630 ? 9.633   1.188   -6.549   0.5  14.203  ? 630  LYS A CD    1 ? 
ATOM   4615  C  CE    A LYS A 1 630 ? 10.767  2.246   -6.344   0.5  27.428  ? 630  LYS A CE    1 ? 
ATOM   4616  C  CE    B LYS A 1 630 ? 10.339  2.544   -6.677   0.5  14.748  ? 630  LYS A CE    1 ? 
ATOM   4617  N  NZ    A LYS A 1 630 ? 10.195  3.178   -7.323   0.5  26.55   ? 630  LYS A NZ    1 ? 
ATOM   4618  N  NZ    B LYS A 1 630 ? 11.135  3.003   -5.526   0.5  11.523  ? 630  LYS A NZ    1 ? 
ATOM   4619  N  N     . ILE A 1 631 ? 5.915   1.847   -3.59    1    16.437  ? 631  ILE A N     1 ? 
ATOM   4620  C  CA    . ILE A 1 631 ? 4.989   2.906   -3.954   1    17.756  ? 631  ILE A CA    1 ? 
ATOM   4621  C  C     . ILE A 1 631 ? 5.592   3.736   -5.073   1    17.738  ? 631  ILE A C     1 ? 
ATOM   4622  O  O     . ILE A 1 631 ? 6.678   4.277   -4.9     1    18.218  ? 631  ILE A O     1 ? 
ATOM   4623  C  CB    . ILE A 1 631 ? 4.733   3.782   -2.726   1    17.47   ? 631  ILE A CB    1 ? 
ATOM   4624  C  CG1   . ILE A 1 631 ? 4.073   2.918   -1.641   1    17.071  ? 631  ILE A CG1   1 ? 
ATOM   4625  C  CG2   . ILE A 1 631 ? 3.847   4.962   -3.153   1    14.749  ? 631  ILE A CG2   1 ? 
ATOM   4626  C  CD1   . ILE A 1 631 ? 4.01    3.601   -0.277   1    18.789  ? 631  ILE A CD1   1 ? 
ATOM   4627  N  N     . ILE A 1 632 ? 4.883   3.847   -6.195   1    15.702  ? 632  ILE A N     1 ? 
ATOM   4628  C  CA    . ILE A 1 632 ? 5.399   4.595   -7.316   1    18.005  ? 632  ILE A CA    1 ? 
ATOM   4629  C  C     . ILE A 1 632 ? 4.916   6.033   -7.161   1    20.872  ? 632  ILE A C     1 ? 
ATOM   4630  O  O     . ILE A 1 632 ? 3.727   6.284   -7.144   1    18.534  ? 632  ILE A O     1 ? 
ATOM   4631  C  CB    . ILE A 1 632 ? 4.901   3.966   -8.626   1    16.629  ? 632  ILE A CB    1 ? 
ATOM   4632  C  CG1   . ILE A 1 632 ? 5.156   2.443   -8.67    1    23.956  ? 632  ILE A CG1   1 ? 
ATOM   4633  C  CG2   . ILE A 1 632 ? 5.477   4.683   -9.849   1    15.978  ? 632  ILE A CG2   1 ? 
ATOM   4634  C  CD1   . ILE A 1 632 ? 6.646   2.083   -8.713   1    23.68   ? 632  ILE A CD1   1 ? 
ATOM   4635  N  N     . SER A 1 633 ? 5.831   6.998   -7.065   1    20.986  ? 633  SER A N     1 ? 
ATOM   4636  C  CA    . SER A 1 633 ? 5.424   8.394   -6.973   1    20.609  ? 633  SER A CA    1 ? 
ATOM   4637  C  C     . SER A 1 633 ? 4.541   8.841   -8.164   1    20.789  ? 633  SER A C     1 ? 
ATOM   4638  O  O     . SER A 1 633 ? 4.698   8.368   -9.308   1    19.64   ? 633  SER A O     1 ? 
ATOM   4639  C  CB    . SER A 1 633 ? 6.675   9.25    -6.795   1    24.557  ? 633  SER A CB    1 ? 
ATOM   4640  O  OG    . SER A 1 633 ? 7.099   9.504   -8.114   1    29.734  ? 633  SER A OG    1 ? 
ATOM   4641  N  N     . LEU A 1 634 ? 3.58    9.762   -7.887   1    19.291  ? 634  LEU A N     1 ? 
ATOM   4642  C  CA    . LEU A 1 634 ? 2.638   10.282  -8.872   1    21.291  ? 634  LEU A CA    1 ? 
ATOM   4643  C  C     . LEU A 1 634 ? 3.311   10.762  -10.149  1    27.899  ? 634  LEU A C     1 ? 
ATOM   4644  O  O     . LEU A 1 634 ? 2.759   10.6    -11.239  1    26.551  ? 634  LEU A O     1 ? 
ATOM   4645  C  CB    . LEU A 1 634 ? 1.794   11.415  -8.286   1    21.288  ? 634  LEU A CB    1 ? 
ATOM   4646  C  CG    . LEU A 1 634 ? 0.814   10.936  -7.221   1    19.609  ? 634  LEU A CG    1 ? 
ATOM   4647  C  CD1   . LEU A 1 634 ? 0.113   12.163  -6.673   1    22.931  ? 634  LEU A CD1   1 ? 
ATOM   4648  C  CD2   . LEU A 1 634 ? -0.158  9.983   -7.965   1    21.431  ? 634  LEU A CD2   1 ? 
ATOM   4649  N  N     . ASP A 1 635 ? 4.509   11.336  -10.066  1    28.585  ? 635  ASP A N     1 ? 
ATOM   4650  C  CA    . ASP A 1 635 ? 4.969   11.897  -11.334  1    40.832  ? 635  ASP A CA    1 ? 
ATOM   4651  C  C     . ASP A 1 635 ? 5.922   10.951  -12.082  1    36.958  ? 635  ASP A C     1 ? 
ATOM   4652  O  O     . ASP A 1 635 ? 6.483   11.321  -13.11   1    36.042  ? 635  ASP A O     1 ? 
ATOM   4653  C  CB    . ASP A 1 635 ? 5.538   13.303  -11.153  1    54.364  ? 635  ASP A CB    1 ? 
ATOM   4654  C  CG    . ASP A 1 635 ? 4.631   14.344  -10.492  1    73.268  ? 635  ASP A CG    1 ? 
ATOM   4655  O  OD1   . ASP A 1 635 ? 3.488   14.546  -11      1    74.557  ? 635  ASP A OD1   1 ? 
ATOM   4656  O  OD2   . ASP A 1 635 ? 5.083   14.974  -9.482   1    68.555  ? 635  ASP A OD2   1 ? 
ATOM   4657  N  N     . ALA A 1 636 ? 6.089   9.712   -11.63   1    29.65   ? 636  ALA A N     1 ? 
ATOM   4658  C  CA    . ALA A 1 636 ? 7.255   8.951   -12.071  1    27.717  ? 636  ALA A CA    1 ? 
ATOM   4659  C  C     . ALA A 1 636 ? 7.214   8.689   -13.578  1    30.574  ? 636  ALA A C     1 ? 
ATOM   4660  O  O     . ALA A 1 636 ? 8.259   8.644   -14.203  1    28.97   ? 636  ALA A O     1 ? 
ATOM   4661  C  CB    . ALA A 1 636 ? 7.38    7.653   -11.294  1    23.259  ? 636  ALA A CB    1 ? 
ATOM   4662  N  N     . TRP A 1 637 ? 6.028   8.465   -14.164  1    24.62   ? 637  TRP A N     1 ? 
ATOM   4663  C  CA    . TRP A 1 637 ? 5.966   8.06    -15.563  1    23.82   ? 637  TRP A CA    1 ? 
ATOM   4664  C  C     . TRP A 1 637 ? 5.452   9.179   -16.479  1    28.406  ? 637  TRP A C     1 ? 
ATOM   4665  O  O     . TRP A 1 637 ? 5.18    8.936   -17.656  1    31.697  ? 637  TRP A O     1 ? 
ATOM   4666  C  CB    . TRP A 1 637 ? 5.106   6.802   -15.761  1    23.193  ? 637  TRP A CB    1 ? 
ATOM   4667  C  CG    . TRP A 1 637 ? 5.564   5.602   -14.977  1    22.537  ? 637  TRP A CG    1 ? 
ATOM   4668  C  CD1   . TRP A 1 637 ? 6.851   5.345   -14.583  1    20.234  ? 637  TRP A CD1   1 ? 
ATOM   4669  C  CD2   . TRP A 1 637 ? 4.749   4.532   -14.447  1    20.91   ? 637  TRP A CD2   1 ? 
ATOM   4670  N  NE1   . TRP A 1 637 ? 6.879   4.19    -13.856  1    18.938  ? 637  TRP A NE1   1 ? 
ATOM   4671  C  CE2   . TRP A 1 637 ? 5.62    3.676   -13.739  1    21.014  ? 637  TRP A CE2   1 ? 
ATOM   4672  C  CE3   . TRP A 1 637 ? 3.379   4.219   -14.474  1    20.474  ? 637  TRP A CE3   1 ? 
ATOM   4673  C  CZ2   . TRP A 1 637 ? 5.18    2.52    -13.085  1    21.954  ? 637  TRP A CZ2   1 ? 
ATOM   4674  C  CZ3   . TRP A 1 637 ? 2.949   3.095   -13.805  1    18.82   ? 637  TRP A CZ3   1 ? 
ATOM   4675  C  CH2   . TRP A 1 637 ? 3.827   2.272   -13.097  1    21.368  ? 637  TRP A CH2   1 ? 
ATOM   4676  N  N     . ARG A 1 638 ? 5.313   10.393  -15.95   1    30.892  ? 638  ARG A N     1 ? 
ATOM   4677  C  CA    . ARG A 1 638 ? 4.879   11.516  -16.766  1    35.244  ? 638  ARG A CA    1 ? 
ATOM   4678  C  C     . ARG A 1 638 ? 6.082   12.06   -17.543  1    36.909  ? 638  ARG A C     1 ? 
ATOM   4679  O  O     . ARG A 1 638 ? 7.164   12.198  -16.987  1    37.238  ? 638  ARG A O     1 ? 
ATOM   4680  C  CB    . ARG A 1 638 ? 4.268   12.58   -15.849  1    33.67   ? 638  ARG A CB    1 ? 
ATOM   4681  C  CG    . ARG A 1 638 ? 3.607   13.741  -16.581  1    43.863  ? 638  ARG A CG    1 ? 
ATOM   4682  C  CD    . ARG A 1 638 ? 3.085   14.777  -15.606  1    45.04   ? 638  ARG A CD    1 ? 
ATOM   4683  N  NE    . ARG A 1 638 ? 4.17    15.721  -15.313  1    66.197  ? 638  ARG A NE    1 ? 
ATOM   4684  C  CZ    . ARG A 1 638 ? 4.184   16.639  -14.346  1    67.551  ? 638  ARG A CZ    1 ? 
ATOM   4685  N  NH1   . ARG A 1 638 ? 3.203   16.714  -13.466  1    59.145  ? 638  ARG A NH1   1 ? 
ATOM   4686  N  NH2   . ARG A 1 638 ? 5.209   17.466  -14.254  1    75.797  ? 638  ARG A NH2   1 ? 
ATOM   4687  N  N     . VAL A 1 639 ? 5.891   12.312  -18.841  1    39.512  ? 639  VAL A N     1 ? 
ATOM   4688  C  CA    . VAL A 1 639 ? 6.904   12.923  -19.692  1    45.586  ? 639  VAL A CA    1 ? 
ATOM   4689  C  C     . VAL A 1 639 ? 6.447   14.347  -20.037  1    43.596  ? 639  VAL A C     1 ? 
ATOM   4690  O  O     . VAL A 1 639 ? 5.336   14.522  -20.541  1    46.318  ? 639  VAL A O     1 ? 
ATOM   4691  C  CB    . VAL A 1 639 ? 7.139   12.073  -20.963  1    47.362  ? 639  VAL A CB    1 ? 
ATOM   4692  C  CG1   . VAL A 1 639 ? 8.03    12.791  -21.984  1    43.419  ? 639  VAL A CG1   1 ? 
ATOM   4693  C  CG2   . VAL A 1 639 ? 7.679   10.676  -20.645  1    46.344  ? 639  VAL A CG2   1 ? 
ATOM   4694  N  N     . ASP A 1 640 ? 7.278   15.357  -19.723  1    46.876  ? 640  ASP A N     1 ? 
ATOM   4695  C  CA    . ASP A 1 640 ? 7.147   16.724  -20.233  1    55.011  ? 640  ASP A CA    1 ? 
ATOM   4696  C  C     . ASP A 1 640 ? 7.266   16.741  -21.758  1    58.032  ? 640  ASP A C     1 ? 
ATOM   4697  O  O     . ASP A 1 640 ? 8.223   16.214  -22.318  1    67.958  ? 640  ASP A O     1 ? 
ATOM   4698  C  CB    . ASP A 1 640 ? 8.248   17.638  -19.72   1    68.061  ? 640  ASP A CB    1 ? 
ATOM   4699  C  CG    . ASP A 1 640 ? 8.061   18.176  -18.311  1    86.651  ? 640  ASP A CG    1 ? 
ATOM   4700  O  OD1   . ASP A 1 640 ? 7.042   18.863  -18.085  1    101.041 ? 640  ASP A OD1   1 ? 
ATOM   4701  O  OD2   . ASP A 1 640 ? 8.941   17.913  -17.459  1    94.598  ? 640  ASP A OD2   1 ? 
ATOM   4702  N  N     . ILE A 1 641 ? 6.321   17.405  -22.429  1    59.404  ? 641  ILE A N     1 ? 
ATOM   4703  C  CA    . ILE A 1 641 ? 6.091   17.201  -23.856  1    59.839  ? 641  ILE A CA    1 ? 
ATOM   4704  C  C     . ILE A 1 641 ? 7.143   17.922  -24.732  1    62.094  ? 641  ILE A C     1 ? 
ATOM   4705  O  O     . ILE A 1 641 ? 7.715   18.94   -24.271  1    64.177  ? 641  ILE A O     1 ? 
ATOM   4706  C  CB    . ILE A 1 641 ? 4.639   17.576  -24.207  1    56.155  ? 641  ILE A CB    1 ? 
ATOM   4707  C  CG1   . ILE A 1 641 ? 4.299   17.24   -25.645  1    52.005  ? 641  ILE A CG1   1 ? 
ATOM   4708  C  CG2   . ILE A 1 641 ? 4.32    19.029  -23.832  1    57.362  ? 641  ILE A CG2   1 ? 
ATOM   4709  C  CD1   . ILE A 1 641 ? 2.982   17.838  -26.092  1    48.194  ? 641  ILE A CD1   1 ? 
ATOM   4710  N  N     . GLY B 1 2   ? -4.499  2.038   -62.487  1    82.025  ? 2    GLY B N     1 ? 
ATOM   4711  C  CA    . GLY B 1 2   ? -5.907  2.154   -62.05   1    89.28   ? 2    GLY B CA    1 ? 
ATOM   4712  C  C     . GLY B 1 2   ? -6.656  0.83    -62.205  1    89.387  ? 2    GLY B C     1 ? 
ATOM   4713  O  O     . GLY B 1 2   ? -6.543  0.188   -63.248  1    95.219  ? 2    GLY B O     1 ? 
ATOM   4714  N  N     . VAL B 1 3   ? -7.414  0.443   -61.161  1    76.574  ? 3    VAL B N     1 ? 
ATOM   4715  C  CA    . VAL B 1 3   ? -8.163  -0.812  -61.112  1    70.09   ? 3    VAL B CA    1 ? 
ATOM   4716  C  C     . VAL B 1 3   ? -9.638  -0.544  -60.785  1    66.828  ? 3    VAL B C     1 ? 
ATOM   4717  O  O     . VAL B 1 3   ? -9.974  0.471   -60.176  1    67.958  ? 3    VAL B O     1 ? 
ATOM   4718  C  CB    . VAL B 1 3   ? -7.585  -1.914  -60.194  1    65.938  ? 3    VAL B CB    1 ? 
ATOM   4719  C  CG1   . VAL B 1 3   ? -6.166  -2.315  -60.584  1    68.242  ? 3    VAL B CG1   1 ? 
ATOM   4720  C  CG2   . VAL B 1 3   ? -7.659  -1.558  -58.713  1    70.011  ? 3    VAL B CG2   1 ? 
ATOM   4721  N  N     . PRO B 1 4   ? -10.575 -1.443  -61.178  1    64.11   ? 4    PRO B N     1 ? 
ATOM   4722  C  CA    . PRO B 1 4   ? -11.989 -1.266  -60.844  1    59.564  ? 4    PRO B CA    1 ? 
ATOM   4723  C  C     . PRO B 1 4   ? -12.255 -1.412  -59.349  1    62.688  ? 4    PRO B C     1 ? 
ATOM   4724  O  O     . PRO B 1 4   ? -11.505 -2.083  -58.64   1    67.705  ? 4    PRO B O     1 ? 
ATOM   4725  C  CB    . PRO B 1 4   ? -12.734 -2.336  -61.677  1    62.476  ? 4    PRO B CB    1 ? 
ATOM   4726  C  CG    . PRO B 1 4   ? -11.696 -2.848  -62.656  1    58.08   ? 4    PRO B CG    1 ? 
ATOM   4727  C  CD    . PRO B 1 4   ? -10.336 -2.642  -62.003  1    58.934  ? 4    PRO B CD    1 ? 
ATOM   4728  N  N     . LYS B 1 5   ? -13.362 -0.798  -58.911  1    64.245  ? 5    LYS B N     1 ? 
ATOM   4729  C  CA    . LYS B 1 5   ? -13.76  -0.682  -57.517  1    68.576  ? 5    LYS B CA    1 ? 
ATOM   4730  C  C     . LYS B 1 5   ? -13.968 -2.057  -56.873  1    60.349  ? 5    LYS B C     1 ? 
ATOM   4731  O  O     . LYS B 1 5   ? -13.504 -2.284  -55.756  1    57.943  ? 5    LYS B O     1 ? 
ATOM   4732  C  CB    . LYS B 1 5   ? -14.932 0.307   -57.39   1    75.824  ? 5    LYS B CB    1 ? 
ATOM   4733  C  CG    . LYS B 1 5   ? -14.56  1.786   -57.545  1    81.756  ? 5    LYS B CG    1 ? 
ATOM   4734  C  CD    . LYS B 1 5   ? -15.707 2.735   -57.891  1    88.062  ? 5    LYS B CD    1 ? 
ATOM   4735  C  CE    . LYS B 1 5   ? -15.22  4.121   -58.215  1    90.216  ? 5    LYS B CE    1 ? 
ATOM   4736  N  NZ    . LYS B 1 5   ? -16.222 4.92    -58.922  1    90.807  ? 5    LYS B NZ    1 ? 
ATOM   4737  N  N     . PHE B 1 6   ? -14.638 -2.982  -57.575  1    54.422  ? 6    PHE B N     1 ? 
ATOM   4738  C  CA    . PHE B 1 6   ? -14.929 -4.287  -56.989  1    49.542  ? 6    PHE B CA    1 ? 
ATOM   4739  C  C     . PHE B 1 6   ? -13.626 -5.051  -56.751  1    52.846  ? 6    PHE B C     1 ? 
ATOM   4740  O  O     . PHE B 1 6   ? -13.461 -5.638  -55.681  1    50.927  ? 6    PHE B O     1 ? 
ATOM   4741  C  CB    . PHE B 1 6   ? -15.995 -5.101  -57.729  1    52.988  ? 6    PHE B CB    1 ? 
ATOM   4742  C  CG    . PHE B 1 6   ? -16.526 -6.33   -56.995  1    53.355  ? 6    PHE B CG    1 ? 
ATOM   4743  C  CD1   . PHE B 1 6   ? -17.055 -6.234  -55.711  1    54.695  ? 6    PHE B CD1   1 ? 
ATOM   4744  C  CD2   . PHE B 1 6   ? -16.491 -7.589  -57.594  1    48.611  ? 6    PHE B CD2   1 ? 
ATOM   4745  C  CE1   . PHE B 1 6   ? -17.552 -7.354  -55.051  1    55.927  ? 6    PHE B CE1   1 ? 
ATOM   4746  C  CE2   . PHE B 1 6   ? -16.988 -8.708  -56.937  1    52.357  ? 6    PHE B CE2   1 ? 
ATOM   4747  C  CZ    . PHE B 1 6   ? -17.514 -8.591  -55.661  1    53.047  ? 6    PHE B CZ    1 ? 
ATOM   4748  N  N     . TYR B 1 7   ? -12.716 -5.018  -57.74   1    50.203  ? 7    TYR B N     1 ? 
ATOM   4749  C  CA    . TYR B 1 7   ? -11.376 -5.587  -57.634  1    49.432  ? 7    TYR B CA    1 ? 
ATOM   4750  C  C     . TYR B 1 7   ? -10.681 -5.115  -56.35   1    55.367  ? 7    TYR B C     1 ? 
ATOM   4751  O  O     . TYR B 1 7   ? -10.368 -5.934  -55.48   1    52.446  ? 7    TYR B O     1 ? 
ATOM   4752  C  CB    . TYR B 1 7   ? -10.51  -5.316  -58.872  1    45.371  ? 7    TYR B CB    1 ? 
ATOM   4753  C  CG    . TYR B 1 7   ? -9.161  -6.036  -58.877  1    53.52   ? 7    TYR B CG    1 ? 
ATOM   4754  C  CD1   . TYR B 1 7   ? -9.053  -7.357  -59.31   1    53.274  ? 7    TYR B CD1   1 ? 
ATOM   4755  C  CD2   . TYR B 1 7   ? -7.993  -5.405  -58.448  1    47.344  ? 7    TYR B CD2   1 ? 
ATOM   4756  C  CE1   . TYR B 1 7   ? -7.833  -8.018  -59.321  1    54.398  ? 7    TYR B CE1   1 ? 
ATOM   4757  C  CE2   . TYR B 1 7   ? -6.768  -6.056  -58.449  1    45.489  ? 7    TYR B CE2   1 ? 
ATOM   4758  C  CZ    . TYR B 1 7   ? -6.689  -7.369  -58.885  1    55.557  ? 7    TYR B CZ    1 ? 
ATOM   4759  O  OH    . TYR B 1 7   ? -5.494  -8.042  -58.894  1    65.254  ? 7    TYR B OH    1 ? 
ATOM   4760  N  N     . ARG B 1 8   ? -10.451 -3.796  -56.234  1    60.878  ? 8    ARG B N     1 ? 
ATOM   4761  C  CA    . ARG B 1 8   ? -9.652  -3.24   -55.148  1    61.601  ? 8    ARG B CA    1 ? 
ATOM   4762  C  C     . ARG B 1 8   ? -10.269 -3.624  -53.804  1    58.517  ? 8    ARG B C     1 ? 
ATOM   4763  O  O     . ARG B 1 8   ? -9.569  -4.051  -52.885  1    53.329  ? 8    ARG B O     1 ? 
ATOM   4764  C  CB    . ARG B 1 8   ? -9.511  -1.719  -55.258  1    70.829  ? 8    ARG B CB    1 ? 
ATOM   4765  C  CG    . ARG B 1 8   ? -8.448  -1.069  -54.379  1    77.311  ? 8    ARG B CG    1 ? 
ATOM   4766  C  CD    . ARG B 1 8   ? -8.496  0.448   -54.549  1    88.769  ? 8    ARG B CD    1 ? 
ATOM   4767  N  NE    . ARG B 1 8   ? -8.255  0.905   -55.926  1    105.964 ? 8    ARG B NE    1 ? 
ATOM   4768  C  CZ    . ARG B 1 8   ? -9.173  1.308   -56.821  1    107.061 ? 8    ARG B CZ    1 ? 
ATOM   4769  N  NH1   . ARG B 1 8   ? -10.466 1.248   -56.539  1    110.747 ? 8    ARG B NH1   1 ? 
ATOM   4770  N  NH2   . ARG B 1 8   ? -8.799  1.746   -58.014  1    86.859  ? 8    ARG B NH2   1 ? 
ATOM   4771  N  N     . TRP B 1 9   ? -11.593 -3.48   -53.712  1    52.044  ? 9    TRP B N     1 ? 
ATOM   4772  C  CA    . TRP B 1 9   ? -12.316 -3.788  -52.491  1    53.828  ? 9    TRP B CA    1 ? 
ATOM   4773  C  C     . TRP B 1 9   ? -12.024 -5.22   -52.056  1    61.053  ? 9    TRP B C     1 ? 
ATOM   4774  O  O     . TRP B 1 9   ? -11.915 -5.497  -50.856  1    47.519  ? 9    TRP B O     1 ? 
ATOM   4775  C  CB    . TRP B 1 9   ? -13.824 -3.595  -52.68   1    47.412  ? 9    TRP B CB    1 ? 
ATOM   4776  C  CG    . TRP B 1 9   ? -14.634 -3.93   -51.455  1    48.19   ? 9    TRP B CG    1 ? 
ATOM   4777  C  CD1   . TRP B 1 9   ? -15.011 -3.072  -50.463  1    50.001  ? 9    TRP B CD1   1 ? 
ATOM   4778  C  CD2   . TRP B 1 9   ? -15.206 -5.214  -51.113  1    51.355  ? 9    TRP B CD2   1 ? 
ATOM   4779  N  NE1   . TRP B 1 9   ? -15.764 -3.728  -49.52   1    56.601  ? 9    TRP B NE1   1 ? 
ATOM   4780  C  CE2   . TRP B 1 9   ? -15.904 -5.041  -49.894  1    54.363  ? 9    TRP B CE2   1 ? 
ATOM   4781  C  CE3   . TRP B 1 9   ? -15.198 -6.483  -51.71   1    52.863  ? 9    TRP B CE3   1 ? 
ATOM   4782  C  CZ2   . TRP B 1 9   ? -16.588 -6.088  -49.278  1    57.507  ? 9    TRP B CZ2   1 ? 
ATOM   4783  C  CZ3   . TRP B 1 9   ? -15.867 -7.52   -51.094  1    53.432  ? 9    TRP B CZ3   1 ? 
ATOM   4784  C  CH2   . TRP B 1 9   ? -16.571 -7.317  -49.903  1    55.805  ? 9    TRP B CH2   1 ? 
ATOM   4785  N  N     . ILE B 1 10  ? -11.946 -6.112  -53.054  1    55.124  ? 10   ILE B N     1 ? 
ATOM   4786  C  CA    . ILE B 1 10  ? -11.681 -7.521  -52.82   1    52.36   ? 10   ILE B CA    1 ? 
ATOM   4787  C  C     . ILE B 1 10  ? -10.256 -7.637  -52.306  1    47.887  ? 10   ILE B C     1 ? 
ATOM   4788  O  O     . ILE B 1 10  ? -10.027 -8.329  -51.307  1    47.642  ? 10   ILE B O     1 ? 
ATOM   4789  C  CB    . ILE B 1 10  ? -11.904 -8.347  -54.103  1    56.726  ? 10   ILE B CB    1 ? 
ATOM   4790  C  CG1   . ILE B 1 10  ? -13.374 -8.711  -54.255  1    50.267  ? 10   ILE B CG1   1 ? 
ATOM   4791  C  CG2   . ILE B 1 10  ? -11.026 -9.601  -54.12   1    61.204  ? 10   ILE B CG2   1 ? 
ATOM   4792  C  CD1   . ILE B 1 10  ? -13.765 -9.017  -55.684  1    60.961  ? 10   ILE B CD1   1 ? 
ATOM   4793  N  N     . SER B 1 11  ? -9.341  -6.949  -53.016  1    42.753  ? 11   SER B N     1 ? 
ATOM   4794  C  CA    . SER B 1 11  ? -7.924  -6.908  -52.694  1    57.92   ? 11   SER B CA    1 ? 
ATOM   4795  C  C     . SER B 1 11  ? -7.748  -6.52   -51.223  1    60.68   ? 11   SER B C     1 ? 
ATOM   4796  O  O     . SER B 1 11  ? -7.078  -7.238  -50.48   1    61.98   ? 11   SER B O     1 ? 
ATOM   4797  C  CB    . SER B 1 11  ? -7.16   -5.968  -53.612  1    62.779  ? 11   SER B CB    1 ? 
ATOM   4798  O  OG    . SER B 1 11  ? -7.501  -6.165  -54.978  1    71.743  ? 11   SER B OG    1 ? 
ATOM   4799  N  N     . GLU B 1 12  ? -8.431  -5.437  -50.809  1    58.081  ? 12   GLU B N     1 ? 
ATOM   4800  C  CA    . GLU B 1 12  ? -8.252  -4.793  -49.509  1    67.438  ? 12   GLU B CA    1 ? 
ATOM   4801  C  C     . GLU B 1 12  ? -8.836  -5.647  -48.386  1    64.685  ? 12   GLU B C     1 ? 
ATOM   4802  O  O     . GLU B 1 12  ? -8.263  -5.71   -47.296  1    66.741  ? 12   GLU B O     1 ? 
ATOM   4803  C  CB    . GLU B 1 12  ? -8.804  -3.364  -49.522  1    64.784  ? 12   GLU B CB    1 ? 
ATOM   4804  C  CG    . GLU B 1 12  ? -7.974  -2.436  -50.411  1    68.584  ? 12   GLU B CG    1 ? 
ATOM   4805  C  CD    . GLU B 1 12  ? -8.375  -0.98   -50.571  1    68.122  ? 12   GLU B CD    1 ? 
ATOM   4806  O  OE1   . GLU B 1 12  ? -9.435  -0.589  -50.044  1    69.628  ? 12   GLU B OE1   1 ? 
ATOM   4807  O  OE2   . GLU B 1 12  ? -7.613  -0.239  -51.233  1    76.837  ? 12   GLU B OE2   1 ? 
ATOM   4808  N  N     . ARG B 1 13  ? -9.979  -6.284  -48.683  1    63.738  ? 13   ARG B N     1 ? 
ATOM   4809  C  CA    . ARG B 1 13  ? -10.652 -7.229  -47.806  1    58.37   ? 13   ARG B CA    1 ? 
ATOM   4810  C  C     . ARG B 1 13  ? -9.79   -8.477  -47.605  1    54.924  ? 13   ARG B C     1 ? 
ATOM   4811  O  O     . ARG B 1 13  ? -9.75   -9.016  -46.502  1    54.209  ? 13   ARG B O     1 ? 
ATOM   4812  C  CB    . ARG B 1 13  ? -12.04  -7.572  -48.357  1    50.254  ? 13   ARG B CB    1 ? 
ATOM   4813  C  CG    . ARG B 1 13  ? -12.874 -8.429  -47.424  1    49.938  ? 13   ARG B CG    1 ? 
ATOM   4814  C  CD    . ARG B 1 13  ? -14.258 -8.753  -47.974  1    52.259  ? 13   ARG B CD    1 ? 
ATOM   4815  N  NE    . ARG B 1 13  ? -15.068 -9.419  -46.945  1    58.974  ? 13   ARG B NE    1 ? 
ATOM   4816  C  CZ    . ARG B 1 13  ? -15.487 -8.814  -45.831  1    57.601  ? 13   ARG B CZ    1 ? 
ATOM   4817  N  NH1   . ARG B 1 13  ? -15.261 -7.521  -45.668  1    47.998  ? 13   ARG B NH1   1 ? 
ATOM   4818  N  NH2   . ARG B 1 13  ? -16.141 -9.49   -44.899  1    62.351  ? 13   ARG B NH2   1 ? 
ATOM   4819  N  N     . TYR B 1 14  ? -9.102  -8.938  -48.659  1    51.177  ? 14   TYR B N     1 ? 
ATOM   4820  C  CA    . TYR B 1 14  ? -8.25   -10.117 -48.538  1    51.026  ? 14   TYR B CA    1 ? 
ATOM   4821  C  C     . TYR B 1 14  ? -6.824  -9.77   -48.968  1    54.302  ? 14   TYR B C     1 ? 
ATOM   4822  O  O     . TYR B 1 14  ? -6.469  -9.933  -50.13   1    47.999  ? 14   TYR B O     1 ? 
ATOM   4823  C  CB    . TYR B 1 14  ? -8.815  -11.322 -49.305  1    53.456  ? 14   TYR B CB    1 ? 
ATOM   4824  C  CG    . TYR B 1 14  ? -10.306 -11.583 -49.121  1    52.486  ? 14   TYR B CG    1 ? 
ATOM   4825  C  CD1   . TYR B 1 14  ? -10.787 -12.262 -48.008  1    54.892  ? 14   TYR B CD1   1 ? 
ATOM   4826  C  CD2   . TYR B 1 14  ? -11.232 -11.158 -50.069  1    60.932  ? 14   TYR B CD2   1 ? 
ATOM   4827  C  CE1   . TYR B 1 14  ? -12.147 -12.488 -47.833  1    66.394  ? 14   TYR B CE1   1 ? 
ATOM   4828  C  CE2   . TYR B 1 14  ? -12.594 -11.385 -49.911  1    64.015  ? 14   TYR B CE2   1 ? 
ATOM   4829  C  CZ    . TYR B 1 14  ? -13.054 -12.049 -48.786  1    66.353  ? 14   TYR B CZ    1 ? 
ATOM   4830  O  OH    . TYR B 1 14  ? -14.396 -12.273 -48.628  1    76.26   ? 14   TYR B OH    1 ? 
ATOM   4831  N  N     . PRO B 1 15  ? -5.955  -9.267  -48.057  1    58.269  ? 15   PRO B N     1 ? 
ATOM   4832  C  CA    . PRO B 1 15  ? -4.539  -9.068  -48.387  1    68.276  ? 15   PRO B CA    1 ? 
ATOM   4833  C  C     . PRO B 1 15  ? -3.905  -10.4   -48.795  1    86.08   ? 15   PRO B C     1 ? 
ATOM   4834  O  O     . PRO B 1 15  ? -4.52   -11.453 -48.625  1    103.149 ? 15   PRO B O     1 ? 
ATOM   4835  C  CB    . PRO B 1 15  ? -3.887  -8.48   -47.118  1    63.232  ? 15   PRO B CB    1 ? 
ATOM   4836  C  CG    . PRO B 1 15  ? -5.041  -8.198  -46.162  1    62.329  ? 15   PRO B CG    1 ? 
ATOM   4837  C  CD    . PRO B 1 15  ? -6.297  -8.87   -46.68   1    57.139  ? 15   PRO B CD    1 ? 
ATOM   4838  N  N     . CYS B 1 16  ? -2.678  -10.348 -49.332  1    95.743  ? 16   CYS B N     1 ? 
ATOM   4839  C  CA    . CYS B 1 16  ? -1.93   -11.535 -49.736  1    101.489 ? 16   CYS B CA    1 ? 
ATOM   4840  C  C     . CYS B 1 16  ? -2.537  -12.151 -51.004  1    97.585  ? 16   CYS B C     1 ? 
ATOM   4841  O  O     . CYS B 1 16  ? -1.948  -13.062 -51.59   1    94.499  ? 16   CYS B O     1 ? 
ATOM   4842  C  CB    . CYS B 1 16  ? -1.847  -12.588 -48.625  1    99.885  ? 16   CYS B CB    1 ? 
ATOM   4843  S  SG    . CYS B 1 16  ? -0.805  -12.177 -47.194  1    89.981  ? 16   CYS B SG    1 ? 
ATOM   4844  N  N     . LEU B 1 17  ? -3.705  -11.643 -51.434  1    86.419  ? 17   LEU B N     1 ? 
ATOM   4845  C  CA    . LEU B 1 17  ? -4.523  -12.318 -52.436  1    77.845  ? 17   LEU B CA    1 ? 
ATOM   4846  C  C     . LEU B 1 17  ? -4.139  -11.885 -53.847  1    72.077  ? 17   LEU B C     1 ? 
ATOM   4847  O  O     . LEU B 1 17  ? -3.651  -12.68  -54.642  1    79.965  ? 17   LEU B O     1 ? 
ATOM   4848  C  CB    . LEU B 1 17  ? -6.024  -12.12  -52.231  1    66.763  ? 17   LEU B CB    1 ? 
ATOM   4849  C  CG    . LEU B 1 17  ? -6.899  -12.564 -53.408  1    58.508  ? 17   LEU B CG    1 ? 
ATOM   4850  C  CD1   . LEU B 1 17  ? -6.867  -14.082 -53.493  1    54.58   ? 17   LEU B CD1   1 ? 
ATOM   4851  C  CD2   . LEU B 1 17  ? -8.322  -12.043 -53.341  1    47.662  ? 17   LEU B CD2   1 ? 
ATOM   4852  N  N     . SER B 1 18  ? -4.444  -10.631 -54.165  1    68.536  ? 18   SER B N     1 ? 
ATOM   4853  C  CA    . SER B 1 18  ? -4.204  -10.126 -55.502  1    68.607  ? 18   SER B CA    1 ? 
ATOM   4854  C  C     . SER B 1 18  ? -2.728  -9.757  -55.612  1    71.277  ? 18   SER B C     1 ? 
ATOM   4855  O  O     . SER B 1 18  ? -2.169  -9.151  -54.693  1    68.929  ? 18   SER B O     1 ? 
ATOM   4856  C  CB    . SER B 1 18  ? -5.117  -8.972  -55.821  1    60.416  ? 18   SER B CB    1 ? 
ATOM   4857  O  OG    . SER B 1 18  ? -4.715  -7.81   -55.112  1    77.532  ? 18   SER B OG    1 ? 
ATOM   4858  N  N     . GLU B 1 19  ? -2.121  -10.16  -56.737  1    66.289  ? 19   GLU B N     1 ? 
ATOM   4859  C  CA    . GLU B 1 19  ? -0.678  -10.11  -56.928  1    73.105  ? 19   GLU B CA    1 ? 
ATOM   4860  C  C     . GLU B 1 19  ? -0.333  -9.133  -58.047  1    67.64   ? 19   GLU B C     1 ? 
ATOM   4861  O  O     . GLU B 1 19  ? -1.132  -8.866  -58.938  1    58.439  ? 19   GLU B O     1 ? 
ATOM   4862  C  CB    . GLU B 1 19  ? -0.091  -11.478 -57.287  1    79.02   ? 19   GLU B CB    1 ? 
ATOM   4863  C  CG    . GLU B 1 19  ? -0.278  -12.531 -56.196  1    89.045  ? 19   GLU B CG    1 ? 
ATOM   4864  C  CD    . GLU B 1 19  ? 0.655   -13.725 -56.273  1    94.099  ? 19   GLU B CD    1 ? 
ATOM   4865  O  OE1   . GLU B 1 19  ? 0.676   -14.422 -57.311  1    89.509  ? 19   GLU B OE1   1 ? 
ATOM   4866  O  OE2   . GLU B 1 19  ? 1.368   -13.951 -55.272  1    104.432 ? 19   GLU B OE2   1 ? 
ATOM   4867  N  N     . VAL B 1 20  ? 0.878   -8.593  -57.986  1    68.453  ? 20   VAL B N     1 ? 
ATOM   4868  C  CA    . VAL B 1 20  ? 1.393   -7.867  -59.126  1    63.498  ? 20   VAL B CA    1 ? 
ATOM   4869  C  C     . VAL B 1 20  ? 2.72    -8.527  -59.501  1    71.511  ? 20   VAL B C     1 ? 
ATOM   4870  O  O     . VAL B 1 20  ? 3.582   -8.725  -58.643  1    71.786  ? 20   VAL B O     1 ? 
ATOM   4871  C  CB    . VAL B 1 20  ? 1.445   -6.343  -58.894  1    67.066  ? 20   VAL B CB    1 ? 
ATOM   4872  C  CG1   . VAL B 1 20  ? 2.044   -5.973  -57.538  1    75.591  ? 20   VAL B CG1   1 ? 
ATOM   4873  C  CG2   . VAL B 1 20  ? 2.116   -5.596  -60.044  1    58.66   ? 20   VAL B CG2   1 ? 
ATOM   4874  N  N     . VAL B 1 21  ? 2.809   -8.94   -60.775  1    71.196  ? 21   VAL B N     1 ? 
ATOM   4875  C  CA    . VAL B 1 21  ? 3.843   -9.827  -61.286  1    68.387  ? 21   VAL B CA    1 ? 
ATOM   4876  C  C     . VAL B 1 21  ? 4.334   -9.299  -62.632  1    69.406  ? 21   VAL B C     1 ? 
ATOM   4877  O  O     . VAL B 1 21  ? 3.565   -8.704  -63.393  1    66.838  ? 21   VAL B O     1 ? 
ATOM   4878  C  CB    . VAL B 1 21  ? 3.336   -11.278 -61.414  1    71.845  ? 21   VAL B CB    1 ? 
ATOM   4879  C  CG1   . VAL B 1 21  ? 2.715   -11.779 -60.114  1    75.31   ? 21   VAL B CG1   1 ? 
ATOM   4880  C  CG2   . VAL B 1 21  ? 2.352   -11.45  -62.571  1    63.555  ? 21   VAL B CG2   1 ? 
ATOM   4881  N  N     . LYS B 1 22  ? 5.629   -9.527  -62.895  1    76.222  ? 22   LYS B N     1 ? 
ATOM   4882  C  CA    . LYS B 1 22  ? 6.28    -9.176  -64.15   1    85.578  ? 22   LYS B CA    1 ? 
ATOM   4883  C  C     . LYS B 1 22  ? 6.001   -10.268 -65.183  1    89.364  ? 22   LYS B C     1 ? 
ATOM   4884  O  O     . LYS B 1 22  ? 5.423   -11.3   -64.844  1    89.915  ? 22   LYS B O     1 ? 
ATOM   4885  C  CB    . LYS B 1 22  ? 7.787   -8.958  -63.954  1    93.091  ? 22   LYS B CB    1 ? 
ATOM   4886  C  CG    . LYS B 1 22  ? 8.246   -7.599  -63.417  1    92.227  ? 22   LYS B CG    1 ? 
ATOM   4887  C  CD    . LYS B 1 22  ? 9.76    -7.401  -63.478  1    94.843  ? 22   LYS B CD    1 ? 
ATOM   4888  C  CE    . LYS B 1 22  ? 10.239  -6.03   -63.096  1    90.099  ? 22   LYS B CE    1 ? 
ATOM   4889  N  NZ    . LYS B 1 22  ? 10.015  -5.716  -61.683  1    76.684  ? 22   LYS B NZ    1 ? 
ATOM   4890  N  N     . GLU B 1 23  ? 6.434   -10.031 -66.431  1    89.041  ? 23   GLU B N     1 ? 
ATOM   4891  C  CA    . GLU B 1 23  ? 6.147   -10.882 -67.579  1    91.469  ? 23   GLU B CA    1 ? 
ATOM   4892  C  C     . GLU B 1 23  ? 6.591   -12.328 -67.335  1    92.705  ? 23   GLU B C     1 ? 
ATOM   4893  O  O     . GLU B 1 23  ? 5.829   -13.262 -67.592  1    80.229  ? 23   GLU B O     1 ? 
ATOM   4894  C  CB    . GLU B 1 23  ? 6.787   -10.281 -68.834  1    92.402  ? 23   GLU B CB    1 ? 
ATOM   4895  C  CG    . GLU B 1 23  ? 6.421   -11.012 -70.125  1    89.643  ? 23   GLU B CG    1 ? 
ATOM   4896  C  CD    . GLU B 1 23  ? 6.786   -10.304 -71.423  1    93.367  ? 23   GLU B CD    1 ? 
ATOM   4897  O  OE1   . GLU B 1 23  ? 6.608   -9.065  -71.504  1    90.115  ? 23   GLU B OE1   1 ? 
ATOM   4898  O  OE2   . GLU B 1 23  ? 7.211   -10.997 -72.374  1    92.972  ? 23   GLU B OE2   1 ? 
ATOM   4899  N  N     . HIS B 1 24  ? 7.819   -12.496 -66.824  1    93.05   ? 24   HIS B N     1 ? 
ATOM   4900  C  CA    . HIS B 1 24  ? 8.483   -13.792 -66.783  1    96.159  ? 24   HIS B CA    1 ? 
ATOM   4901  C  C     . HIS B 1 24  ? 7.943   -14.663 -65.645  1    87.364  ? 24   HIS B C     1 ? 
ATOM   4902  O  O     . HIS B 1 24  ? 8.242   -15.852 -65.596  1    92.655  ? 24   HIS B O     1 ? 
ATOM   4903  C  CB    . HIS B 1 24  ? 10.011  -13.626 -66.745  1    104.91  ? 24   HIS B CB    1 ? 
ATOM   4904  C  CG    . HIS B 1 24  ? 10.598  -13.414 -65.38   1    116.896 ? 24   HIS B CG    1 ? 
ATOM   4905  N  ND1   . HIS B 1 24  ? 10.716  -12.175 -64.784  1    117.04  ? 24   HIS B ND1   1 ? 
ATOM   4906  C  CD2   . HIS B 1 24  ? 11.097  -14.298 -64.497  1    112.274 ? 24   HIS B CD2   1 ? 
ATOM   4907  C  CE1   . HIS B 1 24  ? 11.264  -12.317 -63.584  1    117.701 ? 24   HIS B CE1   1 ? 
ATOM   4908  N  NE2   . HIS B 1 24  ? 11.502  -13.599 -63.39   1    117.26  ? 24   HIS B NE2   1 ? 
ATOM   4909  N  N     . GLN B 1 25  ? 7.155   -14.08  -64.732  1    76.923  ? 25   GLN B N     1 ? 
ATOM   4910  C  CA    . GLN B 1 25  ? 6.707   -14.797 -63.543  1    83.495  ? 25   GLN B CA    1 ? 
ATOM   4911  C  C     . GLN B 1 25  ? 5.236   -15.185 -63.678  1    75.374  ? 25   GLN B C     1 ? 
ATOM   4912  O  O     . GLN B 1 25  ? 4.647   -15.728 -62.741  1    75.993  ? 25   GLN B O     1 ? 
ATOM   4913  C  CB    . GLN B 1 25  ? 6.791   -13.97  -62.257  1    90.004  ? 25   GLN B CB    1 ? 
ATOM   4914  C  CG    . GLN B 1 25  ? 8.106   -13.233 -62.03   1    98.449  ? 25   GLN B CG    1 ? 
ATOM   4915  C  CD    . GLN B 1 25  ? 7.953   -12.083 -61.059  1    102.119 ? 25   GLN B CD    1 ? 
ATOM   4916  O  OE1   . GLN B 1 25  ? 7.868   -10.914 -61.456  1    93.818  ? 25   GLN B OE1   1 ? 
ATOM   4917  N  NE2   . GLN B 1 25  ? 7.861   -12.41  -59.777  1    105.516 ? 25   GLN B NE2   1 ? 
ATOM   4918  N  N     . ILE B 1 26  ? 4.641   -14.867 -64.835  1    68.212  ? 26   ILE B N     1 ? 
ATOM   4919  C  CA    . ILE B 1 26  ? 3.283   -15.29  -65.146  1    69.02   ? 26   ILE B CA    1 ? 
ATOM   4920  C  C     . ILE B 1 26  ? 3.298   -16.807 -65.312  1    62.209  ? 26   ILE B C     1 ? 
ATOM   4921  O  O     . ILE B 1 26  ? 4.106   -17.333 -66.085  1    61.919  ? 26   ILE B O     1 ? 
ATOM   4922  C  CB    . ILE B 1 26  ? 2.757   -14.586 -66.413  1    74.89   ? 26   ILE B CB    1 ? 
ATOM   4923  C  CG1   . ILE B 1 26  ? 2.629   -13.067 -66.209  1    71.542  ? 26   ILE B CG1   1 ? 
ATOM   4924  C  CG2   . ILE B 1 26  ? 1.442   -15.213 -66.885  1    68.301  ? 26   ILE B CG2   1 ? 
ATOM   4925  C  CD1   . ILE B 1 26  ? 2.64    -12.252 -67.489  1    63.44   ? 26   ILE B CD1   1 ? 
ATOM   4926  N  N     . PRO B 1 27  ? 2.408   -17.548 -64.609  1    52.624  ? 27   PRO B N     1 ? 
ATOM   4927  C  CA    . PRO B 1 27  ? 2.39    -19.014 -64.694  1    58.304  ? 27   PRO B CA    1 ? 
ATOM   4928  C  C     . PRO B 1 27  ? 2.074   -19.555 -66.094  1    70.332  ? 27   PRO B C     1 ? 
ATOM   4929  O  O     . PRO B 1 27  ? 1.946   -18.795 -67.066  1    67.215  ? 27   PRO B O     1 ? 
ATOM   4930  C  CB    . PRO B 1 27  ? 1.323   -19.434 -63.67   1    49.671  ? 27   PRO B CB    1 ? 
ATOM   4931  C  CG    . PRO B 1 27  ? 0.46    -18.208 -63.509  1    54.98   ? 27   PRO B CG    1 ? 
ATOM   4932  C  CD    . PRO B 1 27  ? 1.363   -17.008 -63.724  1    47.148  ? 27   PRO B CD    1 ? 
ATOM   4933  N  N     . GLU B 1 28  ? 1.964   -20.888 -66.185  1    64.865  ? 28   GLU B N     1 ? 
ATOM   4934  C  CA    . GLU B 1 28  ? 1.48    -21.532 -67.395  1    59.98   ? 28   GLU B CA    1 ? 
ATOM   4935  C  C     . GLU B 1 28  ? -0.047  -21.516 -67.376  1    50.882  ? 28   GLU B C     1 ? 
ATOM   4936  O  O     . GLU B 1 28  ? -0.652  -21.647 -66.313  1    50.449  ? 28   GLU B O     1 ? 
ATOM   4937  C  CB    . GLU B 1 28  ? 2.081   -22.929 -67.563  1    65.697  ? 28   GLU B CB    1 ? 
ATOM   4938  C  CG    . GLU B 1 28  ? 3.551   -22.878 -67.973  1    85.268  ? 28   GLU B CG    1 ? 
ATOM   4939  C  CD    . GLU B 1 28  ? 4.292   -24.198 -68.122  1    93.924  ? 28   GLU B CD    1 ? 
ATOM   4940  O  OE1   . GLU B 1 28  ? 5.531   -24.136 -68.328  1    93.717  ? 28   GLU B OE1   1 ? 
ATOM   4941  O  OE2   . GLU B 1 28  ? 3.647   -25.272 -68.04   1    92.161  ? 28   GLU B OE2   1 ? 
ATOM   4942  N  N     . PHE B 1 29  ? -0.653  -21.322 -68.554  1    50.275  ? 29   PHE B N     1 ? 
ATOM   4943  C  CA    . PHE B 1 29  ? -2.1    -21.384 -68.688  1    48.028  ? 29   PHE B CA    1 ? 
ATOM   4944  C  C     . PHE B 1 29  ? -2.479  -22.274 -69.871  1    45.225  ? 29   PHE B C     1 ? 
ATOM   4945  O  O     . PHE B 1 29  ? -1.738  -22.361 -70.855  1    41.091  ? 29   PHE B O     1 ? 
ATOM   4946  C  CB    . PHE B 1 29  ? -2.721  -19.995 -68.859  1    49.505  ? 29   PHE B CB    1 ? 
ATOM   4947  C  CG    . PHE B 1 29  ? -2.695  -19.083 -67.637  1    48.434  ? 29   PHE B CG    1 ? 
ATOM   4948  C  CD1   . PHE B 1 29  ? -3.58   -19.29  -66.57   1    49.635  ? 29   PHE B CD1   1 ? 
ATOM   4949  C  CD2   . PHE B 1 29  ? -1.82   -17.996 -67.579  1    48.613  ? 29   PHE B CD2   1 ? 
ATOM   4950  C  CE1   . PHE B 1 29  ? -3.567  -18.454 -65.46   1    50.277  ? 29   PHE B CE1   1 ? 
ATOM   4951  C  CE2   . PHE B 1 29  ? -1.821  -17.146 -66.475  1    47.854  ? 29   PHE B CE2   1 ? 
ATOM   4952  C  CZ    . PHE B 1 29  ? -2.691  -17.38  -65.425  1    46.629  ? 29   PHE B CZ    1 ? 
ATOM   4953  N  N     . ASP B 1 30  ? -3.661  -22.899 -69.756  1    40.344  ? 30   ASP B N     1 ? 
ATOM   4954  C  CA    . ASP B 1 30  ? -4.178  -23.779 -70.79   1    46.46   ? 30   ASP B CA    1 ? 
ATOM   4955  C  C     . ASP B 1 30  ? -5.155  -23.033 -71.705  1    44.606  ? 30   ASP B C     1 ? 
ATOM   4956  O  O     . ASP B 1 30  ? -5.105  -23.172 -72.924  1    45.338  ? 30   ASP B O     1 ? 
ATOM   4957  C  CB    . ASP B 1 30  ? -4.75   -25.04  -70.178  1    45.863  ? 30   ASP B CB    1 ? 
ATOM   4958  C  CG    . ASP B 1 30  ? -3.776  -25.862 -69.341  1    49.373  ? 30   ASP B CG    1 ? 
ATOM   4959  O  OD1   . ASP B 1 30  ? -2.665  -26.153 -69.842  1    45.318  ? 30   ASP B OD1   1 ? 
ATOM   4960  O  OD2   . ASP B 1 30  ? -4.145  -26.217 -68.191  1    46.142  ? 30   ASP B OD2   1 ? 
ATOM   4961  N  N     . ASN B 1 31  ? -6.054  -22.249 -71.103  1    36.972  ? 31   ASN B N     1 ? 
ATOM   4962  C  CA    . ASN B 1 31  ? -7.068  -21.533 -71.846  1    33.901  ? 31   ASN B CA    1 ? 
ATOM   4963  C  C     . ASN B 1 31  ? -6.973  -20.059 -71.48   1    37.411  ? 31   ASN B C     1 ? 
ATOM   4964  O  O     . ASN B 1 31  ? -6.855  -19.724 -70.296  1    36.951  ? 31   ASN B O     1 ? 
ATOM   4965  C  CB    . ASN B 1 31  ? -8.479  -21.982 -71.484  1    33      ? 31   ASN B CB    1 ? 
ATOM   4966  C  CG    . ASN B 1 31  ? -8.731  -23.46  -71.697  1    36.811  ? 31   ASN B CG    1 ? 
ATOM   4967  O  OD1   . ASN B 1 31  ? -7.787  -24.23  -71.912  1    32.502  ? 31   ASN B OD1   1 ? 
ATOM   4968  N  ND2   . ASN B 1 31  ? -9.997  -23.87  -71.628  1    33.527  ? 31   ASN B ND2   1 ? 
ATOM   4969  N  N     . LEU B 1 32  ? -7.048  -19.21  -72.513  1    33.806  ? 32   LEU B N     1 ? 
ATOM   4970  C  CA    . LEU B 1 32  ? -7.131  -17.765 -72.384  1    30.637  ? 32   LEU B CA    1 ? 
ATOM   4971  C  C     . LEU B 1 32  ? -8.423  -17.29  -73.035  1    35.286  ? 32   LEU B C     1 ? 
ATOM   4972  O  O     . LEU B 1 32  ? -8.628  -17.499 -74.238  1    36.324  ? 32   LEU B O     1 ? 
ATOM   4973  C  CB    . LEU B 1 32  ? -5.89   -17.135 -73.025  1    31.278  ? 32   LEU B CB    1 ? 
ATOM   4974  C  CG    . LEU B 1 32  ? -5.944  -15.627 -73.332  1    37.34   ? 32   LEU B CG    1 ? 
ATOM   4975  C  CD1   . LEU B 1 32  ? -6.123  -14.879 -72.013  1    33.965  ? 32   LEU B CD1   1 ? 
ATOM   4976  C  CD2   . LEU B 1 32  ? -4.741  -15.07  -74.159  1    31.16   ? 32   LEU B CD2   1 ? 
ATOM   4977  N  N     . TYR B 1 33  ? -9.284  -16.664 -72.228  1    34.633  ? 33   TYR B N     1 ? 
ATOM   4978  C  CA    . TYR B 1 33  ? -10.52  -16.063 -72.712  1    35.929  ? 33   TYR B CA    1 ? 
ATOM   4979  C  C     . TYR B 1 33  ? -10.331 -14.55  -72.767  1    42.112  ? 33   TYR B C     1 ? 
ATOM   4980  O  O     . TYR B 1 33  ? -9.779  -13.942 -71.838  1    40.02   ? 33   TYR B O     1 ? 
ATOM   4981  C  CB    . TYR B 1 33  ? -11.755 -16.406 -71.875  1    33.116  ? 33   TYR B CB    1 ? 
ATOM   4982  C  CG    . TYR B 1 33  ? -11.747 -17.862 -71.435  1    38.079  ? 33   TYR B CG    1 ? 
ATOM   4983  C  CD1   . TYR B 1 33  ? -11.954 -18.876 -72.359  1    35.043  ? 33   TYR B CD1   1 ? 
ATOM   4984  C  CD2   . TYR B 1 33  ? -11.54  -18.223 -70.102  1    36.258  ? 33   TYR B CD2   1 ? 
ATOM   4985  C  CE1   . TYR B 1 33  ? -11.909 -20.207 -71.985  1    39.638  ? 33   TYR B CE1   1 ? 
ATOM   4986  C  CE2   . TYR B 1 33  ? -11.528 -19.55  -69.708  1    37.063  ? 33   TYR B CE2   1 ? 
ATOM   4987  C  CZ    . TYR B 1 33  ? -11.704 -20.543 -70.659  1    41.233  ? 33   TYR B CZ    1 ? 
ATOM   4988  O  OH    . TYR B 1 33  ? -11.699 -21.859 -70.342  1    39.659  ? 33   TYR B OH    1 ? 
ATOM   4989  N  N     . LEU B 1 34  ? -10.788 -13.951 -73.873  1    34.164  ? 34   LEU B N     1 ? 
ATOM   4990  C  CA    . LEU B 1 34  ? -10.614 -12.523 -74.053  1    33.005  ? 34   LEU B CA    1 ? 
ATOM   4991  C  C     . LEU B 1 34  ? -11.888 -11.912 -74.637  1    35.364  ? 34   LEU B C     1 ? 
ATOM   4992  O  O     . LEU B 1 34  ? -12.294 -12.204 -75.769  1    33.65   ? 34   LEU B O     1 ? 
ATOM   4993  C  CB    . LEU B 1 34  ? -9.411  -12.431 -74.982  1    33.703  ? 34   LEU B CB    1 ? 
ATOM   4994  C  CG    . LEU B 1 34  ? -9.04   -11.04  -75.481  1    39.171  ? 34   LEU B CG    1 ? 
ATOM   4995  C  CD1   . LEU B 1 34  ? -9.009  -10.104 -74.3    1    49.42   ? 34   LEU B CD1   1 ? 
ATOM   4996  C  CD2   . LEU B 1 34  ? -7.657  -11.127 -76.101  1    43.517  ? 34   LEU B CD2   1 ? 
ATOM   4997  N  N     . ASP B 1 35  ? -12.527 -11.073 -73.83   1    30.73   ? 35   ASP B N     1 ? 
ATOM   4998  C  CA    . ASP B 1 35  ? -13.635 -10.247 -74.261  1    34.757  ? 35   ASP B CA    1 ? 
ATOM   4999  C  C     . ASP B 1 35  ? -13.014 -8.992  -74.875  1    40.972  ? 35   ASP B C     1 ? 
ATOM   5000  O  O     . ASP B 1 35  ? -12.255 -8.293  -74.202  1    42.053  ? 35   ASP B O     1 ? 
ATOM   5001  C  CB    . ASP B 1 35  ? -14.589 -9.994  -73.101  1    36.286  ? 35   ASP B CB    1 ? 
ATOM   5002  C  CG    . ASP B 1 35  ? -15.834 -9.168  -73.412  1    48.557  ? 35   ASP B CG    1 ? 
ATOM   5003  O  OD1   . ASP B 1 35  ? -16.731 -9.681  -74.112  1    58.447  ? 35   ASP B OD1   1 ? 
ATOM   5004  O  OD2   . ASP B 1 35  ? -15.909 -8.007  -72.955  1    63.572  ? 35   ASP B OD2   1 ? 
ATOM   5005  N  N     . MET B 1 36  ? -13.333 -8.722  -76.149  1    35.797  ? 36   MET B N     1 ? 
ATOM   5006  C  CA    . MET B 1 36  ? -12.623 -7.737  -76.958  1    37.7    ? 36   MET B CA    1 ? 
ATOM   5007  C  C     . MET B 1 36  ? -13.166 -6.307  -76.783  1    33.661  ? 36   MET B C     1 ? 
ATOM   5008  O  O     . MET B 1 36  ? -12.492 -5.356  -77.16   1    32.123  ? 36   MET B O     1 ? 
ATOM   5009  C  CB    . MET B 1 36  ? -12.754 -8.078  -78.45   1    39.382  ? 36   MET B CB    1 ? 
ATOM   5010  C  CG    . MET B 1 36  ? -12.159 -9.412  -78.888  1    41.379  ? 36   MET B CG    1 ? 
ATOM   5011  S  SD    . MET B 1 36  ? -10.375 -9.298  -78.704  1    56.6    ? 36   MET B SD    1 ? 
ATOM   5012  C  CE    . MET B 1 36  ? -10.111 -8.135  -80.055  1    56.772  ? 36   MET B CE    1 ? 
ATOM   5013  N  N     . ASN B 1 37  ? -14.403 -6.147  -76.304  1    32.891  ? 37   ASN B N     1 ? 
ATOM   5014  C  CA    . ASN B 1 37  ? -15.074 -4.851  -76.305  1    44.46   ? 37   ASN B CA    1 ? 
ATOM   5015  C  C     . ASN B 1 37  ? -14.223 -3.768  -75.623  1    44.986  ? 37   ASN B C     1 ? 
ATOM   5016  O  O     . ASN B 1 37  ? -14.069 -2.685  -76.173  1    49.226  ? 37   ASN B O     1 ? 
ATOM   5017  C  CB    . ASN B 1 37  ? -16.566 -4.946  -75.985  1    44.218  ? 37   ASN B CB    1 ? 
ATOM   5018  C  CG    . ASN B 1 37  ? -17.332 -5.45   -77.194  1    59.03   ? 37   ASN B CG    1 ? 
ATOM   5019  O  OD1   . ASN B 1 37  ? -17.094 -6.573  -77.667  1    59.64   ? 37   ASN B OD1   1 ? 
ATOM   5020  N  ND2   . ASN B 1 37  ? -18.229 -4.632  -77.733  1    53.572  ? 37   ASN B ND2   1 ? 
ATOM   5021  N  N     . GLY B 1 38  ? -13.646 -4.079  -74.457  1    47.398  ? 38   GLY B N     1 ? 
ATOM   5022  C  CA    . GLY B 1 38  ? -12.705 -3.192  -73.784  1    48.937  ? 38   GLY B CA    1 ? 
ATOM   5023  C  C     . GLY B 1 38  ? -11.578 -2.758  -74.721  1    45.617  ? 38   GLY B C     1 ? 
ATOM   5024  O  O     . GLY B 1 38  ? -11.301 -1.562  -74.84   1    42.659  ? 38   GLY B O     1 ? 
ATOM   5025  N  N     . ILE B 1 39  ? -10.952 -3.732  -75.395  1    38.313  ? 39   ILE B N     1 ? 
ATOM   5026  C  CA    . ILE B 1 39  ? -9.861  -3.452  -76.319  1    41.496  ? 39   ILE B CA    1 ? 
ATOM   5027  C  C     . ILE B 1 39  ? -10.332 -2.554  -77.474  1    41.486  ? 39   ILE B C     1 ? 
ATOM   5028  O  O     . ILE B 1 39  ? -9.616  -1.636  -77.884  1    40.434  ? 39   ILE B O     1 ? 
ATOM   5029  C  CB    . ILE B 1 39  ? -9.136  -4.735  -76.795  1    41.368  ? 39   ILE B CB    1 ? 
ATOM   5030  C  CG1   . ILE B 1 39  ? -8.238  -5.308  -75.687  1    38.823  ? 39   ILE B CG1   1 ? 
ATOM   5031  C  CG2   . ILE B 1 39  ? -8.306  -4.466  -78.058  1    36.635  ? 39   ILE B CG2   1 ? 
ATOM   5032  C  CD1   . ILE B 1 39  ? -7.771  -6.749  -75.905  1    33.852  ? 39   ILE B CD1   1 ? 
ATOM   5033  N  N     . ILE B 1 40  ? -11.54  -2.791  -78.002  1    37.673  ? 40   ILE B N     1 ? 
ATOM   5034  C  CA    . ILE B 1 40  ? -11.959 -2.045  -79.179  1    37.684  ? 40   ILE B CA    1 ? 
ATOM   5035  C  C     . ILE B 1 40  ? -12.14  -0.569  -78.799  1    39.873  ? 40   ILE B C     1 ? 
ATOM   5036  O  O     . ILE B 1 40  ? -11.615 0.303   -79.481  1    39.684  ? 40   ILE B O     1 ? 
ATOM   5037  C  CB    . ILE B 1 40  ? -13.216 -2.643  -79.843  1    37.431  ? 40   ILE B CB    1 ? 
ATOM   5038  C  CG1   . ILE B 1 40  ? -12.986 -4.093  -80.327  1    38.456  ? 40   ILE B CG1   1 ? 
ATOM   5039  C  CG2   . ILE B 1 40  ? -13.691 -1.749  -80.986  1    38.93   ? 40   ILE B CG2   1 ? 
ATOM   5040  C  CD1   . ILE B 1 40  ? -14.255 -4.935  -80.338  1    33.293  ? 40   ILE B CD1   1 ? 
ATOM   5041  N  N     . HIS B 1 41  ? -12.859 -0.302  -77.704  1    34.787  ? 41   HIS B N     1 ? 
ATOM   5042  C  CA    . HIS B 1 41  ? -13.029 1.042   -77.16   1    37.826  ? 41   HIS B CA    1 ? 
ATOM   5043  C  C     . HIS B 1 41  ? -11.68  1.743   -76.96   1    39.518  ? 41   HIS B C     1 ? 
ATOM   5044  O  O     . HIS B 1 41  ? -11.52  2.884   -77.391  1    43.042  ? 41   HIS B O     1 ? 
ATOM   5045  C  CB    . HIS B 1 41  ? -13.867 0.986   -75.875  1    38.347  ? 41   HIS B CB    1 ? 
ATOM   5046  C  CG    . HIS B 1 41  ? -15.325 0.8     -76.156  1    38.955  ? 41   HIS B CG    1 ? 
ATOM   5047  N  ND1   . HIS B 1 41  ? -16.14  1.82    -76.606  1    36.597  ? 41   HIS B ND1   1 ? 
ATOM   5048  C  CD2   . HIS B 1 41  ? -16.095 -0.291  -76.093  1    36.626  ? 41   HIS B CD2   1 ? 
ATOM   5049  C  CE1   . HIS B 1 41  ? -17.375 1.358   -76.772  1    40.634  ? 41   HIS B CE1   1 ? 
ATOM   5050  N  NE2   . HIS B 1 41  ? -17.377 0.077   -76.445  1    37.93   ? 41   HIS B NE2   1 ? 
ATOM   5051  N  N     . GLN B 1 42  ? -10.72  1.08    -76.294  1    39.569  ? 42   GLN B N     1 ? 
ATOM   5052  C  CA    . GLN B 1 42  ? -9.431  1.69    -75.971  1    42.625  ? 42   GLN B CA    1 ? 
ATOM   5053  C  C     . GLN B 1 42  ? -8.668  2.093   -77.239  1    46.461  ? 42   GLN B C     1 ? 
ATOM   5054  O  O     . GLN B 1 42  ? -7.985  3.122   -77.252  1    44.528  ? 42   GLN B O     1 ? 
ATOM   5055  C  CB    . GLN B 1 42  ? -8.494  0.823   -75.123  1    51      ? 42   GLN B CB    1 ? 
ATOM   5056  C  CG    . GLN B 1 42  ? -9.005  0.47    -73.726  1    76.136  ? 42   GLN B CG    1 ? 
ATOM   5057  C  CD    . GLN B 1 42  ? -8.108  -0.484  -72.953  1    90.04   ? 42   GLN B CD    1 ? 
ATOM   5058  O  OE1   . GLN B 1 42  ? -8.458  -1.644  -72.683  1    81.722  ? 42   GLN B OE1   1 ? 
ATOM   5059  N  NE2   . GLN B 1 42  ? -6.934  0.004   -72.575  1    92.382  ? 42   GLN B NE2   1 ? 
ATOM   5060  N  N     . CYS B 1 43  ? -8.74   1.252   -78.283  1    39.235  ? 43   CYS B N     1 ? 
ATOM   5061  C  CA    . CYS B 1 43  ? -7.978  1.44    -79.509  1    41.763  ? 43   CYS B CA    1 ? 
ATOM   5062  C  C     . CYS B 1 43  ? -8.662  2.438   -80.449  1    41.806  ? 43   CYS B C     1 ? 
ATOM   5063  O  O     . CYS B 1 43  ? -8      2.961   -81.345  1    36.365  ? 43   CYS B O     1 ? 
ATOM   5064  C  CB    . CYS B 1 43  ? -7.742  0.112   -80.233  1    39.647  ? 43   CYS B CB    1 ? 
ATOM   5065  S  SG    . CYS B 1 43  ? -6.645  -1.009  -79.312  1    40.406  ? 43   CYS B SG    1 ? 
ATOM   5066  N  N     . SER B 1 44  ? -9.985  2.65    -80.281  1    38.936  ? 44   SER B N     1 ? 
ATOM   5067  C  CA    . SER B 1 44  ? -10.744 3.532   -81.159  1    38.798  ? 44   SER B CA    1 ? 
ATOM   5068  C  C     . SER B 1 44  ? -10.979 4.947   -80.586  1    42.671  ? 44   SER B C     1 ? 
ATOM   5069  O  O     . SER B 1 44  ? -11.048 5.9     -81.36   1    42.574  ? 44   SER B O     1 ? 
ATOM   5070  C  CB    . SER B 1 44  ? -12.016 2.898   -81.585  1    35.38   ? 44   SER B CB    1 ? 
ATOM   5071  O  OG    . SER B 1 44  ? -12.802 2.693   -80.429  1    43.259  ? 44   SER B OG    1 ? 
ATOM   5072  N  N     . HIS B 1 45  ? -11.145 5.117   -79.26   1    40.547  ? 45   HIS B N     1 ? 
ATOM   5073  C  CA    . HIS B 1 45  ? -11.401 6.448   -78.708  1    38.073  ? 45   HIS B CA    1 ? 
ATOM   5074  C  C     . HIS B 1 45  ? -10.782 6.583   -77.32   1    40.709  ? 45   HIS B C     1 ? 
ATOM   5075  O  O     . HIS B 1 45  ? -11.495 6.688   -76.322  1    40.712  ? 45   HIS B O     1 ? 
ATOM   5076  C  CB    . HIS B 1 45  ? -12.894 6.798   -78.704  1    38.368  ? 45   HIS B CB    1 ? 
ATOM   5077  C  CG    . HIS B 1 45  ? -13.754 5.923   -77.848  1    44.122  ? 45   HIS B CG    1 ? 
ATOM   5078  N  ND1   . HIS B 1 45  ? -14.405 6.391   -76.729  1    38.51   ? 45   HIS B ND1   1 ? 
ATOM   5079  C  CD2   . HIS B 1 45  ? -14.117 4.629   -77.973  1    38.643  ? 45   HIS B CD2   1 ? 
ATOM   5080  C  CE1   . HIS B 1 45  ? -15.123 5.412   -76.192  1    43.855  ? 45   HIS B CE1   1 ? 
ATOM   5081  N  NE2   . HIS B 1 45  ? -14.954 4.33    -76.929  1    38.191  ? 45   HIS B NE2   1 ? 
ATOM   5082  N  N     . PRO B 1 46  ? -9.431  6.604   -77.239  1    39.38   ? 46   PRO B N     1 ? 
ATOM   5083  C  CA    . PRO B 1 46  ? -8.722  6.743   -75.963  1    40.374  ? 46   PRO B CA    1 ? 
ATOM   5084  C  C     . PRO B 1 46  ? -8.668  8.141   -75.337  1    49.068  ? 46   PRO B C     1 ? 
ATOM   5085  O  O     . PRO B 1 46  ? -8.265  8.274   -74.179  1    44.447  ? 46   PRO B O     1 ? 
ATOM   5086  C  CB    . PRO B 1 46  ? -7.309  6.248   -76.354  1    40.319  ? 46   PRO B CB    1 ? 
ATOM   5087  C  CG    . PRO B 1 46  ? -7.15   6.657   -77.793  1    35.016  ? 46   PRO B CG    1 ? 
ATOM   5088  C  CD    . PRO B 1 46  ? -8.533  6.513   -78.402  1    33.589  ? 46   PRO B CD    1 ? 
ATOM   5089  N  N     . ASN B 1 47  ? -9.074  9.177   -76.095  1    47.607  ? 47   ASN B N     1 ? 
ATOM   5090  C  CA    . ASN B 1 47  ? -8.819  10.56   -75.698  1    52.864  ? 47   ASN B CA    1 ? 
ATOM   5091  C  C     . ASN B 1 47  ? -10.072 11.419  -75.901  1    50.633  ? 47   ASN B C     1 ? 
ATOM   5092  O  O     . ASN B 1 47  ? -10.032 12.435  -76.6    1    48.325  ? 47   ASN B O     1 ? 
ATOM   5093  C  CB    . ASN B 1 47  ? -7.619  11.166  -76.431  1    58.84   ? 47   ASN B CB    1 ? 
ATOM   5094  C  CG    . ASN B 1 47  ? -6.318  10.396  -76.305  1    65.332  ? 47   ASN B CG    1 ? 
ATOM   5095  O  OD1   . ASN B 1 47  ? -5.936  9.93    -75.223  1    70.158  ? 47   ASN B OD1   1 ? 
ATOM   5096  N  ND2   . ASN B 1 47  ? -5.603  10.261  -77.413  1    66.973  ? 47   ASN B ND2   1 ? 
ATOM   5097  N  N     . ASP B 1 48  ? -11.177 10.997  -75.276  1    44.574  ? 48   ASP B N     1 ? 
ATOM   5098  C  CA    . ASP B 1 48  ? -12.503 11.569  -75.462  1    52.297  ? 48   ASP B CA    1 ? 
ATOM   5099  C  C     . ASP B 1 48  ? -12.604 12.995  -74.916  1    60.759  ? 48   ASP B C     1 ? 
ATOM   5100  O  O     . ASP B 1 48  ? -13.552 13.705  -75.254  1    59.651  ? 48   ASP B O     1 ? 
ATOM   5101  C  CB    . ASP B 1 48  ? -13.576 10.693  -74.832  1    51.746  ? 48   ASP B CB    1 ? 
ATOM   5102  C  CG    . ASP B 1 48  ? -14.046 9.52    -75.685  1    55.1    ? 48   ASP B CG    1 ? 
ATOM   5103  O  OD1   . ASP B 1 48  ? -13.622 9.446   -76.874  1    54.322  ? 48   ASP B OD1   1 ? 
ATOM   5104  O  OD2   . ASP B 1 48  ? -14.848 8.708   -75.162  1    51.804  ? 48   ASP B OD2   1 ? 
ATOM   5105  N  N     . ASP B 1 49  ? -11.655 13.379  -74.049  1    60.899  ? 49   ASP B N     1 ? 
ATOM   5106  C  CA    . ASP B 1 49  ? -11.532 14.738  -73.538  1    63.98   ? 49   ASP B CA    1 ? 
ATOM   5107  C  C     . ASP B 1 49  ? -11.125 15.7    -74.652  1    62.592  ? 49   ASP B C     1 ? 
ATOM   5108  O  O     . ASP B 1 49  ? -11.537 16.855  -74.63   1    60.567  ? 49   ASP B O     1 ? 
ATOM   5109  C  CB    . ASP B 1 49  ? -10.555 14.809  -72.377  1    64.295  ? 49   ASP B CB    1 ? 
ATOM   5110  C  CG    . ASP B 1 49  ? -11.061 14.18   -71.088  1    71.267  ? 49   ASP B CG    1 ? 
ATOM   5111  O  OD1   . ASP B 1 49  ? -12.23  14.465  -70.736  1    68.891  ? 49   ASP B OD1   1 ? 
ATOM   5112  O  OD2   . ASP B 1 49  ? -10.285 13.418  -70.451  1    74.084  ? 49   ASP B OD2   1 ? 
ATOM   5113  N  N     . ASP B 1 50  ? -10.344 15.19   -75.619  1    62.753  ? 50   ASP B N     1 ? 
ATOM   5114  C  CA    . ASP B 1 50  ? -9.725  15.93   -76.713  1    58.067  ? 50   ASP B CA    1 ? 
ATOM   5115  C  C     . ASP B 1 50  ? -10.643 15.971  -77.944  1    51.283  ? 50   ASP B C     1 ? 
ATOM   5116  O  O     . ASP B 1 50  ? -10.573 15.095  -78.808  1    44.928  ? 50   ASP B O     1 ? 
ATOM   5117  C  CB    . ASP B 1 50  ? -8.316  15.393  -76.948  1    58.712  ? 50   ASP B CB    1 ? 
ATOM   5118  C  CG    . ASP B 1 50  ? -7.541  15.878  -78.17   1    59.38   ? 50   ASP B CG    1 ? 
ATOM   5119  O  OD1   . ASP B 1 50  ? -8.093  16.66   -78.973  1    56.388  ? 50   ASP B OD1   1 ? 
ATOM   5120  O  OD2   . ASP B 1 50  ? -6.375  15.447  -78.316  1    72.528  ? 50   ASP B OD2   1 ? 
ATOM   5121  N  N     . VAL B 1 51  ? -11.468 17.027  -78.046  1    51.044  ? 51   VAL B N     1 ? 
ATOM   5122  C  CA    . VAL B 1 51  ? -12.443 17.216  -79.117  1    49.186  ? 51   VAL B CA    1 ? 
ATOM   5123  C  C     . VAL B 1 51  ? -11.768 17.206  -80.493  1    47.985  ? 51   VAL B C     1 ? 
ATOM   5124  O  O     . VAL B 1 51  ? -12.443 17.011  -81.508  1    48.463  ? 51   VAL B O     1 ? 
ATOM   5125  C  CB    . VAL B 1 51  ? -13.33  18.466  -78.908  1    57.411  ? 51   VAL B CB    1 ? 
ATOM   5126  C  CG1   . VAL B 1 51  ? -13.905 19.004  -80.211  1    69.248  ? 51   VAL B CG1   1 ? 
ATOM   5127  C  CG2   . VAL B 1 51  ? -14.465 18.208  -77.927  1    52.354  ? 51   VAL B CG2   1 ? 
ATOM   5128  N  N     . HIS B 1 52  ? -10.439 17.388  -80.529  1    52.712  ? 52   HIS B N     1 ? 
ATOM   5129  C  CA    . HIS B 1 52  ? -9.719  17.457  -81.8    1    61.695  ? 52   HIS B CA    1 ? 
ATOM   5130  C  C     . HIS B 1 52  ? -9.222  16.087  -82.27   1    60.278  ? 52   HIS B C     1 ? 
ATOM   5131  O  O     . HIS B 1 52  ? -8.944  15.92   -83.455  1    57.466  ? 52   HIS B O     1 ? 
ATOM   5132  C  CB    . HIS B 1 52  ? -8.536  18.43   -81.735  1    58.903  ? 52   HIS B CB    1 ? 
ATOM   5133  C  CG    . HIS B 1 52  ? -8.957  19.837  -81.476  1    68.805  ? 52   HIS B CG    1 ? 
ATOM   5134  N  ND1   . HIS B 1 52  ? -9.411  20.679  -82.47   1    70.528  ? 52   HIS B ND1   1 ? 
ATOM   5135  C  CD2   . HIS B 1 52  ? -9.01   20.538  -80.334  1    69.314  ? 52   HIS B CD2   1 ? 
ATOM   5136  C  CE1   . HIS B 1 52  ? -9.717  21.852  -81.935  1    74.823  ? 52   HIS B CE1   1 ? 
ATOM   5137  N  NE2   . HIS B 1 52  ? -9.48   21.79   -80.639  1    74.157  ? 52   HIS B NE2   1 ? 
ATOM   5138  N  N     . PHE B 1 53  ? -9.102  15.122  -81.343  1    60.926  ? 53   PHE B N     1 ? 
ATOM   5139  C  CA    . PHE B 1 53  ? -8.509  13.815  -81.612  1    53.751  ? 53   PHE B CA    1 ? 
ATOM   5140  C  C     . PHE B 1 53  ? -9.241  13.111  -82.76   1    48.462  ? 53   PHE B C     1 ? 
ATOM   5141  O  O     . PHE B 1 53  ? -10.465 13.007  -82.768  1    44.084  ? 53   PHE B O     1 ? 
ATOM   5142  C  CB    . PHE B 1 53  ? -8.438  13      -80.314  1    51.286  ? 53   PHE B CB    1 ? 
ATOM   5143  C  CG    . PHE B 1 53  ? -7.939  11.57   -80.487  1    51.637  ? 53   PHE B CG    1 ? 
ATOM   5144  C  CD1   . PHE B 1 53  ? -6.582  11.27   -80.395  1    52.548  ? 53   PHE B CD1   1 ? 
ATOM   5145  C  CD2   . PHE B 1 53  ? -8.827  10.53   -80.761  1    54.507  ? 53   PHE B CD2   1 ? 
ATOM   5146  C  CE1   . PHE B 1 53  ? -6.128  9.961   -80.55   1    57.734  ? 53   PHE B CE1   1 ? 
ATOM   5147  C  CE2   . PHE B 1 53  ? -8.37   9.223   -80.911  1    56.087  ? 53   PHE B CE2   1 ? 
ATOM   5148  C  CZ    . PHE B 1 53  ? -7.019  8.941   -80.81   1    54.058  ? 53   PHE B CZ    1 ? 
ATOM   5149  N  N     . ARG B 1 54  ? -8.465  12.656  -83.748  1    44.612  ? 54   ARG B N     1 ? 
ATOM   5150  C  CA    . ARG B 1 54  ? -8.955  11.822  -84.842  1    49.578  ? 54   ARG B CA    1 ? 
ATOM   5151  C  C     . ARG B 1 54  ? -8.024  10.62   -85.028  1    49.695  ? 54   ARG B C     1 ? 
ATOM   5152  O  O     . ARG B 1 54  ? -6.81   10.72   -84.815  1    44.916  ? 54   ARG B O     1 ? 
ATOM   5153  C  CB    . ARG B 1 54  ? -9.059  12.56   -86.183  1    41.948  ? 54   ARG B CB    1 ? 
ATOM   5154  C  CG    . ARG B 1 54  ? -10.005 13.745  -86.08   1    45.162  ? 54   ARG B CG    1 ? 
ATOM   5155  C  CD    . ARG B 1 54  ? -11.42  13.218  -86.158  1    42.883  ? 54   ARG B CD    1 ? 
ATOM   5156  N  NE    . ARG B 1 54  ? -12.393 14.313  -86.104  1    44.095  ? 54   ARG B NE    1 ? 
ATOM   5157  C  CZ    . ARG B 1 54  ? -12.808 15.011  -85.044  1    41.353  ? 54   ARG B CZ    1 ? 
ATOM   5158  N  NH1   . ARG B 1 54  ? -12.191 14.963  -83.873  1    45.095  ? 54   ARG B NH1   1 ? 
ATOM   5159  N  NH2   . ARG B 1 54  ? -13.88  15.77   -85.167  1    44.332  ? 54   ARG B NH2   1 ? 
ATOM   5160  N  N     . ILE B 1 55  ? -8.619  9.491   -85.441  1    53.942  ? 55   ILE B N     1 ? 
ATOM   5161  C  CA    . ILE B 1 55  ? -7.897  8.249   -85.687  1    51.317  ? 55   ILE B CA    1 ? 
ATOM   5162  C  C     . ILE B 1 55  ? -8.572  7.547   -86.866  1    46.906  ? 55   ILE B C     1 ? 
ATOM   5163  O  O     . ILE B 1 55  ? -9.795  7.5     -86.951  1    49.4    ? 55   ILE B O     1 ? 
ATOM   5164  C  CB    . ILE B 1 55  ? -7.855  7.391   -84.406  1    56.099  ? 55   ILE B CB    1 ? 
ATOM   5165  C  CG1   . ILE B 1 55  ? -6.81   6.268   -84.472  1    59.002  ? 55   ILE B CG1   1 ? 
ATOM   5166  C  CG2   . ILE B 1 55  ? -9.25   6.888   -84.014  1    54.637  ? 55   ILE B CG2   1 ? 
ATOM   5167  C  CD1   . ILE B 1 55  ? -6.697  5.445   -83.196  1    56.248  ? 55   ILE B CD1   1 ? 
ATOM   5168  N  N     . SER B 1 56  ? -7.768  7.049   -87.807  1    37.552  ? 56   SER B N     1 ? 
ATOM   5169  C  CA    . SER B 1 56  ? -8.312  6.353   -88.965  1    43.186  ? 56   SER B CA    1 ? 
ATOM   5170  C  C     . SER B 1 56  ? -8.393  4.849   -88.674  1    39.914  ? 56   SER B C     1 ? 
ATOM   5171  O  O     . SER B 1 56  ? -7.621  4.342   -87.854  1    39.879  ? 56   SER B O     1 ? 
ATOM   5172  C  CB    . SER B 1 56  ? -7.44   6.624   -90.152  1    45.421  ? 56   SER B CB    1 ? 
ATOM   5173  O  OG    . SER B 1 56  ? -6.093  6.6     -89.696  1    45.843  ? 56   SER B OG    1 ? 
ATOM   5174  N  N     . ASP B 1 57  ? -9.323  4.155   -89.353  1    40.519  ? 57   ASP B N     1 ? 
ATOM   5175  C  CA    . ASP B 1 57  ? -9.596  2.736   -89.135  1    41.361  ? 57   ASP B CA    1 ? 
ATOM   5176  C  C     . ASP B 1 57  ? -8.317  1.903   -89.193  1    41.377  ? 57   ASP B C     1 ? 
ATOM   5177  O  O     . ASP B 1 57  ? -8.147  0.98    -88.402  1    39.993  ? 57   ASP B O     1 ? 
ATOM   5178  C  CB    . ASP B 1 57  ? -10.61  2.178   -90.12   1    39.662  ? 57   ASP B CB    1 ? 
ATOM   5179  C  CG    . ASP B 1 57  ? -12.022 2.714   -89.945  1    42.302  ? 57   ASP B CG    1 ? 
ATOM   5180  O  OD1   . ASP B 1 57  ? -12.248 3.42    -88.942  1    45.372  ? 57   ASP B OD1   1 ? 
ATOM   5181  O  OD2   . ASP B 1 57  ? -12.869 2.459   -90.825  1    44.234  ? 57   ASP B OD2   1 ? 
ATOM   5182  N  N     . ASP B 1 58  ? -7.428  2.235   -90.131  1    37.282  ? 58   ASP B N     1 ? 
ATOM   5183  C  CA    . ASP B 1 58  ? -6.218  1.454   -90.321  1    46.268  ? 58   ASP B CA    1 ? 
ATOM   5184  C  C     . ASP B 1 58  ? -5.455  1.471   -89.006  1    47.989  ? 58   ASP B C     1 ? 
ATOM   5185  O  O     . ASP B 1 58  ? -4.903  0.45    -88.607  1    44.836  ? 58   ASP B O     1 ? 
ATOM   5186  C  CB    . ASP B 1 58  ? -5.381  1.952   -91.495  1    53.259  ? 58   ASP B CB    1 ? 
ATOM   5187  C  CG    . ASP B 1 58  ? -4.779  3.348   -91.336  1    52.483  ? 58   ASP B CG    1 ? 
ATOM   5188  O  OD1   . ASP B 1 58  ? -5.507  4.257   -90.892  1    60.308  ? 58   ASP B OD1   1 ? 
ATOM   5189  O  OD2   . ASP B 1 58  ? -3.583  3.523   -91.65   1    49.179  ? 58   ASP B OD2   1 ? 
ATOM   5190  N  N     . LYS B 1 59  ? -5.452  2.637   -88.341  1    44.669  ? 59   LYS B N     1 ? 
ATOM   5191  C  CA    . LYS B 1 59  ? -4.73   2.788   -87.083  1    49.113  ? 59   LYS B CA    1 ? 
ATOM   5192  C  C     . LYS B 1 59  ? -5.476  2.03    -85.971  1    44.492  ? 59   LYS B C     1 ? 
ATOM   5193  O  O     . LYS B 1 59  ? -4.846  1.389   -85.128  1    42.675  ? 59   LYS B O     1 ? 
ATOM   5194  C  CB    . LYS B 1 59  ? -4.277  4.248   -86.866  1    47.492  ? 59   LYS B CB    1 ? 
ATOM   5195  C  CG    . LYS B 1 59  ? -3.406  4.564   -85.633  1    60.644  ? 59   LYS B CG    1 ? 
ATOM   5196  C  CD    . LYS B 1 59  ? -2.359  3.552   -85.141  1    62.745  ? 59   LYS B CD    1 ? 
ATOM   5197  C  CE    . LYS B 1 59  ? -1.234  4.04    -84.256  1    52.103  ? 59   LYS B CE    1 ? 
ATOM   5198  N  NZ    . LYS B 1 59  ? -1.653  4.392   -82.892  1    50.306  ? 59   LYS B NZ    1 ? 
ATOM   5199  N  N     . ILE B 1 60  ? -6.818  2.053   -86.003  1    38.579  ? 60   ILE B N     1 ? 
ATOM   5200  C  CA    . ILE B 1 60  ? -7.616  1.334   -85.016  1    42.623  ? 60   ILE B CA    1 ? 
ATOM   5201  C  C     . ILE B 1 60  ? -7.281  -0.163  -85.07   1    40.603  ? 60   ILE B C     1 ? 
ATOM   5202  O  O     . ILE B 1 60  ? -6.873  -0.758  -84.073  1    42.596  ? 60   ILE B O     1 ? 
ATOM   5203  C  CB    . ILE B 1 60  ? -9.12   1.612   -85.202  1    38.435  ? 60   ILE B CB    1 ? 
ATOM   5204  C  CG1   . ILE B 1 60  ? -9.454  3.093   -84.968  1    35.985  ? 60   ILE B CG1   1 ? 
ATOM   5205  C  CG2   . ILE B 1 60  ? -9.948  0.71    -84.286  1    39.652  ? 60   ILE B CG2   1 ? 
ATOM   5206  C  CD1   . ILE B 1 60  ? -10.908 3.425   -85.249  1    32.163  ? 60   ILE B CD1   1 ? 
ATOM   5207  N  N     . PHE B 1 61  ? -7.405  -0.744  -86.265  1    42.475  ? 61   PHE B N     1 ? 
ATOM   5208  C  CA    . PHE B 1 61  ? -7.245  -2.176  -86.48   1    41.176  ? 61   PHE B CA    1 ? 
ATOM   5209  C  C     . PHE B 1 61  ? -5.818  -2.601  -86.168  1    42.034  ? 61   PHE B C     1 ? 
ATOM   5210  O  O     . PHE B 1 61  ? -5.634  -3.609  -85.485  1    40.665  ? 61   PHE B O     1 ? 
ATOM   5211  C  CB    . PHE B 1 61  ? -7.59   -2.515  -87.927  1    36.701  ? 61   PHE B CB    1 ? 
ATOM   5212  C  CG    . PHE B 1 61  ? -8.995  -2.143  -88.362  1    35.021  ? 61   PHE B CG    1 ? 
ATOM   5213  C  CD1   . PHE B 1 61  ? -10.026 -2.011  -87.434  1    36.351  ? 61   PHE B CD1   1 ? 
ATOM   5214  C  CD2   . PHE B 1 61  ? -9.284  -1.977  -89.716  1    32.274  ? 61   PHE B CD2   1 ? 
ATOM   5215  C  CE1   . PHE B 1 61  ? -11.322 -1.712  -87.847  1    35.619  ? 61   PHE B CE1   1 ? 
ATOM   5216  C  CE2   . PHE B 1 61  ? -10.574 -1.674  -90.118  1    37.316  ? 61   PHE B CE2   1 ? 
ATOM   5217  C  CZ    . PHE B 1 61  ? -11.592 -1.536  -89.183  1    36.375  ? 61   PHE B CZ    1 ? 
ATOM   5218  N  N     . THR B 1 62  ? -4.829  -1.835  -86.666  1    43.435  ? 62   THR B N     1 ? 
ATOM   5219  C  CA    . THR B 1 62  ? -3.425  -2.086  -86.368  1    42.993  ? 62   THR B CA    1 ? 
ATOM   5220  C  C     . THR B 1 62  ? -3.274  -2.209  -84.856  1    45.354  ? 62   THR B C     1 ? 
ATOM   5221  O  O     . THR B 1 62  ? -2.5    -3.044  -84.378  1    41.451  ? 62   THR B O     1 ? 
ATOM   5222  C  CB    . THR B 1 62  ? -2.55   -0.932  -86.856  1    44.018  ? 62   THR B CB    1 ? 
ATOM   5223  O  OG1   . THR B 1 62  ? -2.632  -0.948  -88.272  1    46.652  ? 62   THR B OG1   1 ? 
ATOM   5224  C  CG2   . THR B 1 62  ? -1.109  -1.036  -86.389  1    40.148  ? 62   THR B CG2   1 ? 
ATOM   5225  N  N     . ASP B 1 63  ? -3.977  -1.32   -84.128  1    38.087  ? 63   ASP B N     1 ? 
ATOM   5226  C  CA    . ASP B 1 63  ? -3.784  -1.242  -82.69   1    41.314  ? 63   ASP B CA    1 ? 
ATOM   5227  C  C     . ASP B 1 63  ? -4.461  -2.427  -82.016  1    39.344  ? 63   ASP B C     1 ? 
ATOM   5228  O  O     . ASP B 1 63  ? -3.898  -2.979  -81.068  1    37.561  ? 63   ASP B O     1 ? 
ATOM   5229  C  CB    . ASP B 1 63  ? -4.144  0.117   -82.093  1    46.579  ? 63   ASP B CB    1 ? 
ATOM   5230  C  CG    . ASP B 1 63  ? -3.11   1.222   -82.316  1    52.28   ? 63   ASP B CG    1 ? 
ATOM   5231  O  OD1   . ASP B 1 63  ? -2.052  0.916   -82.951  1    46.554  ? 63   ASP B OD1   1 ? 
ATOM   5232  O  OD2   . ASP B 1 63  ? -3.37   2.382   -81.866  1    48.024  ? 63   ASP B OD2   1 ? 
ATOM   5233  N  N     . ILE B 1 64  ? -5.674  -2.763  -82.485  1    40.067  ? 64   ILE B N     1 ? 
ATOM   5234  C  CA    . ILE B 1 64  ? -6.4    -3.91   -81.956  1    39.354  ? 64   ILE B CA    1 ? 
ATOM   5235  C  C     . ILE B 1 64  ? -5.515  -5.142  -82.135  1    36.536  ? 64   ILE B C     1 ? 
ATOM   5236  O  O     . ILE B 1 64  ? -5.37   -5.924  -81.205  1    44.159  ? 64   ILE B O     1 ? 
ATOM   5237  C  CB    . ILE B 1 64  ? -7.792  -4.043  -82.599  1    31.997  ? 64   ILE B CB    1 ? 
ATOM   5238  C  CG1   . ILE B 1 64  ? -8.703  -2.892  -82.17   1    32.743  ? 64   ILE B CG1   1 ? 
ATOM   5239  C  CG2   . ILE B 1 64  ? -8.417  -5.388  -82.239  1    30.443  ? 64   ILE B CG2   1 ? 
ATOM   5240  C  CD1   . ILE B 1 64  ? -9.94   -2.712  -83.041  1    32.213  ? 64   ILE B CD1   1 ? 
ATOM   5241  N  N     . PHE B 1 65  ? -4.819  -5.222  -83.277  1    38.698  ? 65   PHE B N     1 ? 
ATOM   5242  C  CA    . PHE B 1 65  ? -3.967  -6.359  -83.604  1    45.301  ? 65   PHE B CA    1 ? 
ATOM   5243  C  C     . PHE B 1 65  ? -2.826  -6.491  -82.591  1    51.107  ? 65   PHE B C     1 ? 
ATOM   5244  O  O     . PHE B 1 65  ? -2.523  -7.6    -82.123  1    44.985  ? 65   PHE B O     1 ? 
ATOM   5245  C  CB    . PHE B 1 65  ? -3.439  -6.364  -85.049  1    42.293  ? 65   PHE B CB    1 ? 
ATOM   5246  C  CG    . PHE B 1 65  ? -4.447  -6.475  -86.192  1    40.368  ? 65   PHE B CG    1 ? 
ATOM   5247  C  CD1   . PHE B 1 65  ? -5.795  -6.721  -85.956  1    40.628  ? 65   PHE B CD1   1 ? 
ATOM   5248  C  CD2   . PHE B 1 65  ? -4.038  -6.355  -87.521  1    36.071  ? 65   PHE B CD2   1 ? 
ATOM   5249  C  CE1   . PHE B 1 65  ? -6.709  -6.793  -87.007  1    39.65   ? 65   PHE B CE1   1 ? 
ATOM   5250  C  CE2   . PHE B 1 65  ? -4.95   -6.424  -88.564  1    36.333  ? 65   PHE B CE2   1 ? 
ATOM   5251  C  CZ    . PHE B 1 65  ? -6.287  -6.648  -88.309  1    40.156  ? 65   PHE B CZ    1 ? 
ATOM   5252  N  N     . HIS B 1 66  ? -2.204  -5.346  -82.256  1    52.594  ? 66   HIS B N     1 ? 
ATOM   5253  C  CA    . HIS B 1 66  ? -1.085  -5.308  -81.325  1    58.309  ? 66   HIS B CA    1 ? 
ATOM   5254  C  C     . HIS B 1 66  ? -1.474  -5.882  -79.969  1    51.695  ? 66   HIS B C     1 ? 
ATOM   5255  O  O     . HIS B 1 66  ? -0.703  -6.64   -79.375  1    48.217  ? 66   HIS B O     1 ? 
ATOM   5256  C  CB    . HIS B 1 66  ? -0.497  -3.901  -81.176  1    68.671  ? 66   HIS B CB    1 ? 
ATOM   5257  C  CG    . HIS B 1 66  ? 0.554   -3.645  -82.186  1    81.476  ? 66   HIS B CG    1 ? 
ATOM   5258  N  ND1   . HIS B 1 66  ? 1.789   -3.13   -81.862  1    89.627  ? 66   HIS B ND1   1 ? 
ATOM   5259  C  CD2   . HIS B 1 66  ? 0.573   -3.895  -83.503  1    87.606  ? 66   HIS B CD2   1 ? 
ATOM   5260  C  CE1   . HIS B 1 66  ? 2.518   -3.043  -82.965  1    95.801  ? 66   HIS B CE1   1 ? 
ATOM   5261  N  NE2   . HIS B 1 66  ? 1.797   -3.501  -83.972  1    95.092  ? 66   HIS B NE2   1 ? 
ATOM   5262  N  N     . TYR B 1 67  ? -2.665  -5.498  -79.5    1    44.354  ? 67   TYR B N     1 ? 
ATOM   5263  C  CA    . TYR B 1 67  ? -3.176  -5.951  -78.218  1    48.888  ? 67   TYR B CA    1 ? 
ATOM   5264  C  C     . TYR B 1 67  ? -3.24   -7.482  -78.206  1    47.109  ? 67   TYR B C     1 ? 
ATOM   5265  O  O     . TYR B 1 67  ? -2.765  -8.113  -77.264  1    47.694  ? 67   TYR B O     1 ? 
ATOM   5266  C  CB    . TYR B 1 67  ? -4.55   -5.301  -78.015  1    53.961  ? 67   TYR B CB    1 ? 
ATOM   5267  C  CG    . TYR B 1 67  ? -4.628  -4.448  -76.758  1    57.453  ? 67   TYR B CG    1 ? 
ATOM   5268  C  CD1   . TYR B 1 67  ? -4.608  -5.037  -75.496  1    65.097  ? 67   TYR B CD1   1 ? 
ATOM   5269  C  CD2   . TYR B 1 67  ? -4.688  -3.059  -76.832  1    55.542  ? 67   TYR B CD2   1 ? 
ATOM   5270  C  CE1   . TYR B 1 67  ? -4.65   -4.272  -74.34   1    61.018  ? 67   TYR B CE1   1 ? 
ATOM   5271  C  CE2   . TYR B 1 67  ? -4.726  -2.284  -75.68   1    65.751  ? 67   TYR B CE2   1 ? 
ATOM   5272  C  CZ    . TYR B 1 67  ? -4.71   -2.894  -74.434  1    65.107  ? 67   TYR B CZ    1 ? 
ATOM   5273  O  OH    . TYR B 1 67  ? -4.765  -2.163  -73.287  1    84.941  ? 67   TYR B OH    1 ? 
ATOM   5274  N  N     . LEU B 1 68  ? -3.813  -8.067  -79.27   1    43.468  ? 68   LEU B N     1 ? 
ATOM   5275  C  CA    . LEU B 1 68  ? -4.021  -9.507  -79.356  1    41.288  ? 68   LEU B CA    1 ? 
ATOM   5276  C  C     . LEU B 1 68  ? -2.678  -10.211 -79.405  1    40.551  ? 68   LEU B C     1 ? 
ATOM   5277  O  O     . LEU B 1 68  ? -2.492  -11.226 -78.74   1    44.243  ? 68   LEU B O     1 ? 
ATOM   5278  C  CB    . LEU B 1 68  ? -4.853  -9.89   -80.577  1    41.899  ? 68   LEU B CB    1 ? 
ATOM   5279  C  CG    . LEU B 1 68  ? -6.293  -9.377  -80.556  1    47.916  ? 68   LEU B CG    1 ? 
ATOM   5280  C  CD1   . LEU B 1 68  ? -6.951  -9.436  -81.929  1    45.098  ? 68   LEU B CD1   1 ? 
ATOM   5281  C  CD2   . LEU B 1 68  ? -7.054  -10.2   -79.542  1    43.442  ? 68   LEU B CD2   1 ? 
ATOM   5282  N  N     . GLU B 1 69  ? -1.757  -9.647  -80.186  1    37.913  ? 69   GLU B N     1 ? 
ATOM   5283  C  CA    . GLU B 1 69  ? -0.426  -10.21  -80.375  1    44.048  ? 69   GLU B CA    1 ? 
ATOM   5284  C  C     . GLU B 1 69  ? 0.341   -10.224 -79.055  1    41.083  ? 69   GLU B C     1 ? 
ATOM   5285  O  O     . GLU B 1 69  ? 0.918   -11.238 -78.656  1    40.971  ? 69   GLU B O     1 ? 
ATOM   5286  C  CB    . GLU B 1 69  ? 0.243   -9.396  -81.487  1    54.154  ? 69   GLU B CB    1 ? 
ATOM   5287  C  CG    . GLU B 1 69  ? 1.663   -9.847  -81.812  1    66.08   ? 69   GLU B CG    1 ? 
ATOM   5288  C  CD    . GLU B 1 69  ? 1.967   -9.81   -83.302  1    70.816  ? 69   GLU B CD    1 ? 
ATOM   5289  O  OE1   . GLU B 1 69  ? 1.097   -9.429  -84.116  1    63.261  ? 69   GLU B OE1   1 ? 
ATOM   5290  O  OE2   . GLU B 1 69  ? 3.104   -10.183 -83.644  1    86.684  ? 69   GLU B OE2   1 ? 
ATOM   5291  N  N     . VAL B 1 70  ? 0.322   -9.087  -78.353  1    39.704  ? 70   VAL B N     1 ? 
ATOM   5292  C  CA    . VAL B 1 70  ? 1.047   -8.984  -77.103  1    40.341  ? 70   VAL B CA    1 ? 
ATOM   5293  C  C     . VAL B 1 70  ? 0.43    -9.883  -76.027  1    44.624  ? 70   VAL B C     1 ? 
ATOM   5294  O  O     . VAL B 1 70  ? 1.149   -10.59  -75.306  1    44.708  ? 70   VAL B O     1 ? 
ATOM   5295  C  CB    . VAL B 1 70  ? 1.064   -7.504  -76.697  1    44.413  ? 70   VAL B CB    1 ? 
ATOM   5296  C  CG1   . VAL B 1 70  ? 1.414   -7.336  -75.218  1    54.967  ? 70   VAL B CG1   1 ? 
ATOM   5297  C  CG2   . VAL B 1 70  ? 2.006   -6.721  -77.605  1    41.761  ? 70   VAL B CG2   1 ? 
ATOM   5298  N  N     . LEU B 1 71  ? -0.903  -9.848  -75.905  1    40.393  ? 71   LEU B N     1 ? 
ATOM   5299  C  CA    . LEU B 1 71  ? -1.565  -10.609 -74.854  1    40.068  ? 71   LEU B CA    1 ? 
ATOM   5300  C  C     . LEU B 1 71  ? -1.299  -12.1   -75.061  1    39.582  ? 71   LEU B C     1 ? 
ATOM   5301  O  O     . LEU B 1 71  ? -0.958  -12.817 -74.115  1    41.376  ? 71   LEU B O     1 ? 
ATOM   5302  C  CB    . LEU B 1 71  ? -3.049  -10.26  -74.723  1    37.244  ? 71   LEU B CB    1 ? 
ATOM   5303  C  CG    . LEU B 1 71  ? -3.342  -8.88   -74.114  1    42.37   ? 71   LEU B CG    1 ? 
ATOM   5304  C  CD1   . LEU B 1 71  ? -4.812  -8.506  -74.169  1    37.411  ? 71   LEU B CD1   1 ? 
ATOM   5305  C  CD2   . LEU B 1 71  ? -2.815  -8.72   -72.682  1    39.078  ? 71   LEU B CD2   1 ? 
ATOM   5306  N  N     . PHE B 1 72  ? -1.414  -12.543 -76.319  1    42.428  ? 72   PHE B N     1 ? 
ATOM   5307  C  CA    . PHE B 1 72  ? -1.175  -13.928 -76.697  1    41.787  ? 72   PHE B CA    1 ? 
ATOM   5308  C  C     . PHE B 1 72  ? 0.282   -14.312 -76.418  1    42.207  ? 72   PHE B C     1 ? 
ATOM   5309  O  O     . PHE B 1 72  ? 0.544   -15.374 -75.85   1    45.126  ? 72   PHE B O     1 ? 
ATOM   5310  C  CB    . PHE B 1 72  ? -1.483  -14.184 -78.178  1    44.774  ? 72   PHE B CB    1 ? 
ATOM   5311  C  CG    . PHE B 1 72  ? -1.441  -15.67  -78.509  1    40.268  ? 72   PHE B CG    1 ? 
ATOM   5312  C  CD1   . PHE B 1 72  ? -0.243  -16.289 -78.854  1    41.745  ? 72   PHE B CD1   1 ? 
ATOM   5313  C  CD2   . PHE B 1 72  ? -2.593  -16.439 -78.424  1    43.18   ? 72   PHE B CD2   1 ? 
ATOM   5314  C  CE1   . PHE B 1 72  ? -0.206  -17.647 -79.13   1    46.035  ? 72   PHE B CE1   1 ? 
ATOM   5315  C  CE2   . PHE B 1 72  ? -2.557  -17.793 -78.723  1    48.4    ? 72   PHE B CE2   1 ? 
ATOM   5316  C  CZ    . PHE B 1 72  ? -1.366  -18.395 -79.059  1    43.616  ? 72   PHE B CZ    1 ? 
ATOM   5317  N  N     . ARG B 1 73  ? 1.222   -13.448 -76.819  1    42.976  ? 73   ARG B N     1 ? 
ATOM   5318  C  CA    . ARG B 1 73  ? 2.641   -13.704 -76.608  1    46.838  ? 73   ARG B CA    1 ? 
ATOM   5319  C  C     . ARG B 1 73  ? 2.956   -13.853 -75.115  1    52.019  ? 73   ARG B C     1 ? 
ATOM   5320  O  O     . ARG B 1 73  ? 3.837   -14.608 -74.725  1    51.618  ? 73   ARG B O     1 ? 
ATOM   5321  C  CB    . ARG B 1 73  ? 3.489   -12.567 -77.193  1    53.654  ? 73   ARG B CB    1 ? 
ATOM   5322  C  CG    . ARG B 1 73  ? 4.987   -12.854 -77.154  1    59.529  ? 73   ARG B CG    1 ? 
ATOM   5323  C  CD    . ARG B 1 73  ? 5.876   -11.651 -77.437  1    61.511  ? 73   ARG B CD    1 ? 
ATOM   5324  N  NE    . ARG B 1 73  ? 5.894   -10.749 -76.277  1    70.696  ? 73   ARG B NE    1 ? 
ATOM   5325  C  CZ    . ARG B 1 73  ? 5.585   -9.454  -76.286  1    67.871  ? 73   ARG B CZ    1 ? 
ATOM   5326  N  NH1   . ARG B 1 73  ? 5.27    -8.858  -77.422  1    70.576  ? 73   ARG B NH1   1 ? 
ATOM   5327  N  NH2   . ARG B 1 73  ? 5.613   -8.762  -75.159  1    61.182  ? 73   ARG B NH2   1 ? 
ATOM   5328  N  N     . ILE B 1 74  ? 2.247   -13.119 -74.261  1    49.083  ? 74   ILE B N     1 ? 
ATOM   5329  C  CA    . ILE B 1 74  ? 2.658   -13.05  -72.867  1    50.817  ? 74   ILE B CA    1 ? 
ATOM   5330  C  C     . ILE B 1 74  ? 1.958   -14.131 -72.049  1    46.223  ? 74   ILE B C     1 ? 
ATOM   5331  O  O     . ILE B 1 74  ? 2.582   -14.721 -71.178  1    53.13   ? 74   ILE B O     1 ? 
ATOM   5332  C  CB    . ILE B 1 74  ? 2.471   -11.621 -72.313  1    55.775  ? 74   ILE B CB    1 ? 
ATOM   5333  C  CG1   . ILE B 1 74  ? 3.461   -10.645 -72.97   1    52.937  ? 74   ILE B CG1   1 ? 
ATOM   5334  C  CG2   . ILE B 1 74  ? 2.589   -11.594 -70.791  1    61.349  ? 74   ILE B CG2   1 ? 
ATOM   5335  C  CD1   . ILE B 1 74  ? 3.251   -9.185  -72.601  1    68.582  ? 74   ILE B CD1   1 ? 
ATOM   5336  N  N     . ILE B 1 75  ? 0.68    -14.408 -72.338  1    43.966  ? 75   ILE B N     1 ? 
ATOM   5337  C  CA    . ILE B 1 75  ? -0.071  -15.4   -71.582  1    44.575  ? 75   ILE B CA    1 ? 
ATOM   5338  C  C     . ILE B 1 75  ? 0.209   -16.813 -72.085  1    49.289  ? 75   ILE B C     1 ? 
ATOM   5339  O  O     . ILE B 1 75  ? 0.093   -17.747 -71.296  1    51.372  ? 75   ILE B O     1 ? 
ATOM   5340  C  CB    . ILE B 1 75  ? -1.574  -15.074 -71.558  1    45.23   ? 75   ILE B CB    1 ? 
ATOM   5341  C  CG1   . ILE B 1 75  ? -1.817  -13.741 -70.826  1    44.617  ? 75   ILE B CG1   1 ? 
ATOM   5342  C  CG2   . ILE B 1 75  ? -2.354  -16.217 -70.906  1    43.894  ? 75   ILE B CG2   1 ? 
ATOM   5343  C  CD1   . ILE B 1 75  ? -2.967  -12.917 -71.366  1    38.855  ? 75   ILE B CD1   1 ? 
ATOM   5344  N  N     . LYS B 1 76  ? 0.551   -16.953 -73.381  1    51.282  ? 76   LYS B N     1 ? 
ATOM   5345  C  CA    . LYS B 1 76  ? 0.95    -18.204 -74.03   1    50.589  ? 76   LYS B CA    1 ? 
ATOM   5346  C  C     . LYS B 1 76  ? -0.013  -19.353 -73.706  1    46.565  ? 76   LYS B C     1 ? 
ATOM   5347  O  O     . LYS B 1 76  ? 0.398   -20.394 -73.192  1    41.266  ? 76   LYS B O     1 ? 
ATOM   5348  C  CB    . LYS B 1 76  ? 2.364   -18.683 -73.671  1    53.195  ? 76   LYS B CB    1 ? 
ATOM   5349  C  CG    . LYS B 1 76  ? 3.448   -17.631 -73.655  1    59.324  ? 76   LYS B CG    1 ? 
ATOM   5350  C  CD    . LYS B 1 76  ? 4.859   -18.208 -73.604  1    70.378  ? 76   LYS B CD    1 ? 
ATOM   5351  C  CE    . LYS B 1 76  ? 5.946   -17.17  -73.495  1    78.035  ? 76   LYS B CE    1 ? 
ATOM   5352  N  NZ    . LYS B 1 76  ? 6.063   -16.288 -74.662  1    76.058  ? 76   LYS B NZ    1 ? 
ATOM   5353  N  N     . PRO B 1 77  ? -1.314  -19.253 -74.05   1    42.688  ? 77   PRO B N     1 ? 
ATOM   5354  C  CA    . PRO B 1 77  ? -2.261  -20.296 -73.657  1    41.72   ? 77   PRO B CA    1 ? 
ATOM   5355  C  C     . PRO B 1 77  ? -1.823  -21.57  -74.379  1    45.41   ? 77   PRO B C     1 ? 
ATOM   5356  O  O     . PRO B 1 77  ? -1.547  -21.539 -75.573  1    47.289  ? 77   PRO B O     1 ? 
ATOM   5357  C  CB    . PRO B 1 77  ? -3.6    -19.752 -74.181  1    38.008  ? 77   PRO B CB    1 ? 
ATOM   5358  C  CG    . PRO B 1 77  ? -3.202  -18.862 -75.367  1    36.286  ? 77   PRO B CG    1 ? 
ATOM   5359  C  CD    . PRO B 1 77  ? -1.91   -18.192 -74.879  1    38.601  ? 77   PRO B CD    1 ? 
ATOM   5360  N  N     . ARG B 1 78  ? -1.782  -22.697 -73.663  1    47.3    ? 78   ARG B N     1 ? 
ATOM   5361  C  CA    . ARG B 1 78  ? -1.19   -23.896 -74.24   1    44.066  ? 78   ARG B CA    1 ? 
ATOM   5362  C  C     . ARG B 1 78  ? -2.203  -24.739 -75.012  1    41.419  ? 78   ARG B C     1 ? 
ATOM   5363  O  O     . ARG B 1 78  ? -1.776  -25.525 -75.839  1    40.84   ? 78   ARG B O     1 ? 
ATOM   5364  C  CB    . ARG B 1 78  ? -0.533  -24.746 -73.15   1    53.678  ? 78   ARG B CB    1 ? 
ATOM   5365  C  CG    . ARG B 1 78  ? 0.648   -24.03  -72.514  1    59.321  ? 78   ARG B CG    1 ? 
ATOM   5366  C  CD    . ARG B 1 78  ? 0.863   -24.676 -71.162  1    62.656  ? 78   ARG B CD    1 ? 
ATOM   5367  N  NE    . ARG B 1 78  ? 1.445   -26.009 -71.34   1    68.707  ? 78   ARG B NE    1 ? 
ATOM   5368  C  CZ    . ARG B 1 78  ? 2.716   -26.225 -71.654  1    73.833  ? 78   ARG B CZ    1 ? 
ATOM   5369  N  NH1   . ARG B 1 78  ? 3.568   -25.213 -71.746  1    76.076  ? 78   ARG B NH1   1 ? 
ATOM   5370  N  NH2   . ARG B 1 78  ? 3.128   -27.46  -71.862  1    74.12   ? 78   ARG B NH2   1 ? 
ATOM   5371  N  N     . LYS B 1 79  ? -3.515  -24.593 -74.736  1    35.756  ? 79   LYS B N     1 ? 
ATOM   5372  C  CA    . LYS B 1 79  ? -4.547  -25.439 -75.325  1    36.182  ? 79   LYS B CA    1 ? 
ATOM   5373  C  C     . LYS B 1 79  ? -5.564  -24.641 -76.15   1    41.389  ? 79   LYS B C     1 ? 
ATOM   5374  O  O     . LYS B 1 79  ? -5.856  -25.029 -77.276  1    39.371  ? 79   LYS B O     1 ? 
ATOM   5375  C  CB    . LYS B 1 79  ? -5.257  -26.299 -74.268  1    35.718  ? 79   LYS B CB    1 ? 
ATOM   5376  C  CG    . LYS B 1 79  ? -4.343  -27.368 -73.625  1    43.691  ? 79   LYS B CG    1 ? 
ATOM   5377  C  CD    . LYS B 1 79  ? -3.91   -28.401 -74.66   1    55.895  ? 79   LYS B CD    1 ? 
ATOM   5378  C  CE    . LYS B 1 79  ? -2.582  -29.068 -74.453  1    66.856  ? 79   LYS B CE    1 ? 
ATOM   5379  N  NZ    . LYS B 1 79  ? -2.493  -29.68  -73.127  1    58.64   ? 79   LYS B NZ    1 ? 
ATOM   5380  N  N     . VAL B 1 80  ? -6.129  -23.555 -75.586  1    41.46   ? 80   VAL B N     1 ? 
ATOM   5381  C  CA    . VAL B 1 80  ? -7.286  -22.876 -76.164  1    40.59   ? 80   VAL B CA    1 ? 
ATOM   5382  C  C     . VAL B 1 80  ? -7.122  -21.361 -76.043  1    43.843  ? 80   VAL B C     1 ? 
ATOM   5383  O  O     . VAL B 1 80  ? -6.703  -20.877 -74.986  1    37.347  ? 80   VAL B O     1 ? 
ATOM   5384  C  CB    . VAL B 1 80  ? -8.591  -23.293 -75.455  1    38.296  ? 80   VAL B CB    1 ? 
ATOM   5385  C  CG1   . VAL B 1 80  ? -9.773  -22.402 -75.863  1    34.677  ? 80   VAL B CG1   1 ? 
ATOM   5386  C  CG2   . VAL B 1 80  ? -8.893  -24.78  -75.632  1    36.547  ? 80   VAL B CG2   1 ? 
ATOM   5387  N  N     . PHE B 1 81  ? -7.538  -20.636 -77.097  1    38.419  ? 81   PHE B N     1 ? 
ATOM   5388  C  CA    . PHE B 1 81  ? -7.632  -19.179 -77.129  1    36.743  ? 81   PHE B CA    1 ? 
ATOM   5389  C  C     . PHE B 1 81  ? -9.001  -18.79  -77.68   1    38.058  ? 81   PHE B C     1 ? 
ATOM   5390  O  O     . PHE B 1 81  ? -9.326  -19.099 -78.823  1    38.004  ? 81   PHE B O     1 ? 
ATOM   5391  C  CB    . PHE B 1 81  ? -6.509  -18.528 -77.943  1    35.35   ? 81   PHE B CB    1 ? 
ATOM   5392  C  CG    . PHE B 1 81  ? -6.554  -17.003 -78.059  1    45.663  ? 81   PHE B CG    1 ? 
ATOM   5393  C  CD1   . PHE B 1 81  ? -6.956  -16.201 -76.995  1    43.282  ? 81   PHE B CD1   1 ? 
ATOM   5394  C  CD2   . PHE B 1 81  ? -6.187  -16.363 -79.242  1    50.505  ? 81   PHE B CD2   1 ? 
ATOM   5395  C  CE1   . PHE B 1 81  ? -6.989  -14.816 -77.107  1    44.654  ? 81   PHE B CE1   1 ? 
ATOM   5396  C  CE2   . PHE B 1 81  ? -6.204  -14.974 -79.343  1    51.586  ? 81   PHE B CE2   1 ? 
ATOM   5397  C  CZ    . PHE B 1 81  ? -6.612  -14.207 -78.28   1    48.853  ? 81   PHE B CZ    1 ? 
ATOM   5398  N  N     . PHE B 1 82  ? -9.816  -18.142 -76.84   1    32.131  ? 82   PHE B N     1 ? 
ATOM   5399  C  CA    . PHE B 1 82  ? -11.197 -17.843 -77.171  1    35.649  ? 82   PHE B CA    1 ? 
ATOM   5400  C  C     . PHE B 1 82  ? -11.347 -16.324 -77.191  1    41.65   ? 82   PHE B C     1 ? 
ATOM   5401  O  O     . PHE B 1 82  ? -11.219 -15.683 -76.136  1    37.465  ? 82   PHE B O     1 ? 
ATOM   5402  C  CB    . PHE B 1 82  ? -12.181 -18.44  -76.161  1    29.719  ? 82   PHE B CB    1 ? 
ATOM   5403  C  CG    . PHE B 1 82  ? -13.651 -18.456 -76.573  1    30.258  ? 82   PHE B CG    1 ? 
ATOM   5404  C  CD1   . PHE B 1 82  ? -14.429 -17.306 -76.555  1    30.616  ? 82   PHE B CD1   1 ? 
ATOM   5405  C  CD2   . PHE B 1 82  ? -14.272 -19.643 -76.952  1    30.266  ? 82   PHE B CD2   1 ? 
ATOM   5406  C  CE1   . PHE B 1 82  ? -15.775 -17.341 -76.913  1    32.873  ? 82   PHE B CE1   1 ? 
ATOM   5407  C  CE2   . PHE B 1 82  ? -15.613 -19.679 -77.309  1    33.084  ? 82   PHE B CE2   1 ? 
ATOM   5408  C  CZ    . PHE B 1 82  ? -16.369 -18.523 -77.292  1    34.819  ? 82   PHE B CZ    1 ? 
ATOM   5409  N  N     . MET B 1 83  ? -11.603 -15.777 -78.399  1    38.02   ? 83   MET B N     1 ? 
ATOM   5410  C  CA    . MET B 1 83  ? -11.778 -14.348 -78.63   1    33.334  ? 83   MET B CA    1 ? 
ATOM   5411  C  C     . MET B 1 83  ? -13.255 -14.057 -78.859  1    35.711  ? 83   MET B C     1 ? 
ATOM   5412  O  O     . MET B 1 83  ? -13.859 -14.637 -79.761  1    40.384  ? 83   MET B O     1 ? 
ATOM   5413  C  CB    . MET B 1 83  ? -11.052 -13.909 -79.907  1    37.421  ? 83   MET B CB    1 ? 
ATOM   5414  C  CG    . MET B 1 83  ? -9.554  -13.8   -79.808  1    47.023  ? 83   MET B CG    1 ? 
ATOM   5415  S  SD    . MET B 1 83  ? -8.895  -13.339 -81.429  1    60.429  ? 83   MET B SD    1 ? 
ATOM   5416  C  CE    . MET B 1 83  ? -9.872  -11.846 -81.66   1    50.876  ? 83   MET B CE    1 ? 
ATOM   5417  N  N     . ALA B 1 84  ? -13.814 -13.129 -78.069  1    32.34   ? 84   ALA B N     1 ? 
ATOM   5418  C  CA    . ALA B 1 84  ? -15.227 -12.811 -78.148  1    31.908  ? 84   ALA B CA    1 ? 
ATOM   5419  C  C     . ALA B 1 84  ? -15.45  -11.305 -78.353  1    33.091  ? 84   ALA B C     1 ? 
ATOM   5420  O  O     . ALA B 1 84  ? -14.797 -10.471 -77.73   1    30.739  ? 84   ALA B O     1 ? 
ATOM   5421  C  CB    . ALA B 1 84  ? -15.954 -13.342 -76.933  1    26.986  ? 84   ALA B CB    1 ? 
ATOM   5422  N  N     . VAL B 1 85  ? -16.375 -10.987 -79.264  1    30.548  ? 85   VAL B N     1 ? 
ATOM   5423  C  CA    . VAL B 1 85  ? -16.865 -9.645  -79.514  1    28.347  ? 85   VAL B CA    1 ? 
ATOM   5424  C  C     . VAL B 1 85  ? -18.351 -9.743  -79.247  1    32.25   ? 85   VAL B C     1 ? 
ATOM   5425  O  O     . VAL B 1 85  ? -18.962 -10.737 -79.635  1    35.7    ? 85   VAL B O     1 ? 
ATOM   5426  C  CB    . VAL B 1 85  ? -16.577 -9.265  -80.984  1    29.418  ? 85   VAL B CB    1 ? 
ATOM   5427  C  CG1   . VAL B 1 85  ? -17.306 -7.999  -81.424  1    30.505  ? 85   VAL B CG1   1 ? 
ATOM   5428  C  CG2   . VAL B 1 85  ? -15.083 -9.163  -81.264  1    25.255  ? 85   VAL B CG2   1 ? 
ATOM   5429  N  N     . ASP B 1 86  ? -18.906 -8.742  -78.558  1    28.272  ? 86   ASP B N     1 ? 
ATOM   5430  C  CA    . ASP B 1 86  ? -20.328 -8.719  -78.256  1    31.263  ? 86   ASP B CA    1 ? 
ATOM   5431  C  C     . ASP B 1 86  ? -21.166 -8.861  -79.53   1    34.066  ? 86   ASP B C     1 ? 
ATOM   5432  O  O     . ASP B 1 86  ? -20.96  -8.129  -80.497  1    33.436  ? 86   ASP B O     1 ? 
ATOM   5433  C  CB    . ASP B 1 86  ? -20.706 -7.439  -77.526  1    33.408  ? 86   ASP B CB    1 ? 
ATOM   5434  C  CG    . ASP B 1 86  ? -20.155 -7.26   -76.114  1    38.33   ? 86   ASP B CG    1 ? 
ATOM   5435  O  OD1   . ASP B 1 86  ? -19.424 -8.15   -75.618  1    34.401  ? 86   ASP B OD1   1 ? 
ATOM   5436  O  OD2   . ASP B 1 86  ? -20.448 -6.202  -75.522  1    47.121  ? 86   ASP B OD2   1 ? 
ATOM   5437  N  N     . GLY B 1 87  ? -22.103 -9.82   -79.517  1    31.647  ? 87   GLY B N     1 ? 
ATOM   5438  C  CA    . GLY B 1 87  ? -23.167 -9.861  -80.501  1    30.661  ? 87   GLY B CA    1 ? 
ATOM   5439  C  C     . GLY B 1 87  ? -24.399 -9.236  -79.868  1    30.878  ? 87   GLY B C     1 ? 
ATOM   5440  O  O     . GLY B 1 87  ? -24.289 -8.714  -78.768  1    35.417  ? 87   GLY B O     1 ? 
ATOM   5441  N  N     . VAL B 1 88  ? -25.54  -9.289  -80.559  1    29.975  ? 88   VAL B N     1 ? 
ATOM   5442  C  CA    . VAL B 1 88  ? -26.813 -8.786  -80.048  1    32.232  ? 88   VAL B CA    1 ? 
ATOM   5443  C  C     . VAL B 1 88  ? -27.086 -9.345  -78.654  1    36.468  ? 88   VAL B C     1 ? 
ATOM   5444  O  O     . VAL B 1 88  ? -26.956 -10.556 -78.408  1    33.027  ? 88   VAL B O     1 ? 
ATOM   5445  C  CB    . VAL B 1 88  ? -27.954 -9.125  -81.037  1    33.547  ? 88   VAL B CB    1 ? 
ATOM   5446  C  CG1   . VAL B 1 88  ? -29.333 -8.831  -80.459  1    30.345  ? 88   VAL B CG1   1 ? 
ATOM   5447  C  CG2   . VAL B 1 88  ? -27.773 -8.384  -82.368  1    34.154  ? 88   VAL B CG2   1 ? 
ATOM   5448  N  N     . ALA B 1 89  ? -27.511 -8.444  -77.754  1    35.012  ? 89   ALA B N     1 ? 
ATOM   5449  C  CA    . ALA B 1 89  ? -27.702 -8.764  -76.345  1    31.082  ? 89   ALA B CA    1 ? 
ATOM   5450  C  C     . ALA B 1 89  ? -29.174 -9.042  -76.033  1    32.526  ? 89   ALA B C     1 ? 
ATOM   5451  O  O     . ALA B 1 89  ? -30.07  -8.579  -76.739  1    29.111  ? 89   ALA B O     1 ? 
ATOM   5452  C  CB    . ALA B 1 89  ? -27.16  -7.644  -75.471  1    29.428  ? 89   ALA B CB    1 ? 
ATOM   5453  N  N     . PRO B 1 90  ? -29.469 -9.778  -74.929  1    30.172  ? 90   PRO B N     1 ? 
ATOM   5454  C  CA    . PRO B 1 90  ? -30.844 -9.937  -74.464  1    32.535  ? 90   PRO B CA    1 ? 
ATOM   5455  C  C     . PRO B 1 90  ? -31.387 -8.538  -74.176  1    32.335  ? 90   PRO B C     1 ? 
ATOM   5456  O  O     . PRO B 1 90  ? -30.623 -7.666  -73.788  1    28.686  ? 90   PRO B O     1 ? 
ATOM   5457  C  CB    . PRO B 1 90  ? -30.694 -10.781 -73.185  1    34.271  ? 90   PRO B CB    1 ? 
ATOM   5458  C  CG    . PRO B 1 90  ? -29.343 -11.446 -73.312  1    34.589  ? 90   PRO B CG    1 ? 
ATOM   5459  C  CD    . PRO B 1 90  ? -28.48  -10.491 -74.095  1    32.084  ? 90   PRO B CD    1 ? 
ATOM   5460  N  N     . ARG B 1 91  ? -32.708 -8.356  -74.293  1    29.879  ? 91   ARG B N     1 ? 
ATOM   5461  C  CA    . ARG B 1 91  ? -33.368 -7.091  -73.999  1    32.817  ? 91   ARG B CA    1 ? 
ATOM   5462  C  C     . ARG B 1 91  ? -32.996 -6.547  -72.61   1    35.841  ? 91   ARG B C     1 ? 
ATOM   5463  O  O     . ARG B 1 91  ? -32.935 -5.329  -72.4    1    33.866  ? 91   ARG B O     1 ? 
ATOM   5464  C  CB    . ARG B 1 91  ? -34.896 -7.256  -74.08   1    37.026  ? 91   ARG B CB    1 ? 
ATOM   5465  C  CG    . ARG B 1 91  ? -35.686 -5.963  -73.905  1    45.288  ? 91   ARG B CG    1 ? 
ATOM   5466  C  CD    . ARG B 1 91  ? -35.485 -4.972  -75.081  1    49.513  ? 91   ARG B CD    1 ? 
ATOM   5467  N  NE    . ARG B 1 91  ? -35.933 -3.602  -74.786  1    49.268  ? 91   ARG B NE    1 ? 
ATOM   5468  C  CZ    . ARG B 1 91  ? -37.216 -3.253  -74.662  1    55.654  ? 91   ARG B CZ    1 ? 
ATOM   5469  N  NH1   . ARG B 1 91  ? -37.523 -2.128  -74.044  1    49.604  ? 91   ARG B NH1   1 ? 
ATOM   5470  N  NH2   . ARG B 1 91  ? -38.191 -4.069  -75.067  1    50.102  ? 91   ARG B NH2   1 ? 
ATOM   5471  N  N     . ALA B 1 92  ? -32.768 -7.448  -71.647  1    36.156  ? 92   ALA B N     1 ? 
ATOM   5472  C  CA    . ALA B 1 92  ? -32.539 -7.031  -70.274  1    39.641  ? 92   ALA B CA    1 ? 
ATOM   5473  C  C     . ALA B 1 92  ? -31.268 -6.205  -70.191  1    42.547  ? 92   ALA B C     1 ? 
ATOM   5474  O  O     . ALA B 1 92  ? -31.132 -5.405  -69.275  1    46.657  ? 92   ALA B O     1 ? 
ATOM   5475  C  CB    . ALA B 1 92  ? -32.419 -8.232  -69.372  1    37.013  ? 92   ALA B CB    1 ? 
ATOM   5476  N  N     . LYS B 1 93  ? -30.334 -6.451  -71.115  1    40.86   ? 93   LYS B N     1 ? 
ATOM   5477  C  CA    . LYS B 1 93  ? -29.083 -5.711  -71.161  1    43.819  ? 93   LYS B CA    1 ? 
ATOM   5478  C  C     . LYS B 1 93  ? -29.241 -4.473  -72.039  1    48.998  ? 93   LYS B C     1 ? 
ATOM   5479  O  O     . LYS B 1 93  ? -28.398 -3.584  -72.005  1    49.478  ? 93   LYS B O     1 ? 
ATOM   5480  C  CB    . LYS B 1 93  ? -27.896 -6.535  -71.686  1    44.55   ? 93   LYS B CB    1 ? 
ATOM   5481  C  CG    . LYS B 1 93  ? -27.564 -7.83   -70.942  1    52.78   ? 93   LYS B CG    1 ? 
ATOM   5482  C  CD    . LYS B 1 93  ? -27.742 -7.776  -69.428  1    51.512  ? 93   LYS B CD    1 ? 
ATOM   5483  C  CE    . LYS B 1 93  ? -26.551 -8.369  -68.759  1    56.969  ? 93   LYS B CE    1 ? 
ATOM   5484  N  NZ    . LYS B 1 93  ? -25.409 -7.491  -69.051  1    57.72   ? 93   LYS B NZ    1 ? 
ATOM   5485  N  N     . MET B 1 94  ? -30.327 -4.403  -72.814  1    53.297  ? 94   MET B N     1 ? 
ATOM   5486  C  CA    . MET B 1 94  ? -30.414 -3.377  -73.844  1    55.429  ? 94   MET B CA    1 ? 
ATOM   5487  C  C     . MET B 1 94  ? -30.727 -1.994  -73.275  1    44.934  ? 94   MET B C     1 ? 
ATOM   5488  O  O     . MET B 1 94  ? -30.374 -0.989  -73.891  1    47.972  ? 94   MET B O     1 ? 
ATOM   5489  C  CB    . MET B 1 94  ? -31.374 -3.746  -74.988  1    59.469  ? 94   MET B CB    1 ? 
ATOM   5490  C  CG    . MET B 1 94  ? -30.784 -4.719  -76.007  1    55.029  ? 94   MET B CG    1 ? 
ATOM   5491  S  SD    . MET B 1 94  ? -31.756 -4.853  -77.524  1    62.954  ? 94   MET B SD    1 ? 
ATOM   5492  C  CE    . MET B 1 94  ? -30.947 -6.23   -78.339  1    43.619  ? 94   MET B CE    1 ? 
ATOM   5493  N  N     . ASN B 1 95  ? -31.368 -1.917  -72.108  1    44.857  ? 95   ASN B N     1 ? 
ATOM   5494  C  CA    A ASN B 1 95  ? -31.706 -0.619  -71.523  0.5  45.653  ? 95   ASN B CA    1 ? 
ATOM   5495  C  CA    B ASN B 1 95  ? -31.709 -0.614  -71.567  0.5  43.923  ? 95   ASN B CA    1 ? 
ATOM   5496  C  C     . ASN B 1 95  ? -30.437 0.079   -71.06   1    42.829  ? 95   ASN B C     1 ? 
ATOM   5497  O  O     . ASN B 1 95  ? -30.274 1.293   -71.223  1    41.335  ? 95   ASN B O     1 ? 
ATOM   5498  C  CB    A ASN B 1 95  ? -32.598 -0.666  -70.284  0.5  49.806  ? 95   ASN B CB    1 ? 
ATOM   5499  C  CB    B ASN B 1 95  ? -32.946 -0.758  -70.688  0.5  44.743  ? 95   ASN B CB    1 ? 
ATOM   5500  C  CG    A ASN B 1 95  ? -32.583 0.649   -69.524  0.5  49.084  ? 95   ASN B CG    1 ? 
ATOM   5501  C  CG    B ASN B 1 95  ? -33.8   -1.912  -71.17   0.5  39.903  ? 95   ASN B CG    1 ? 
ATOM   5502  O  OD1   A ASN B 1 95  ? -32.89  1.703   -70.095  0.5  49.488  ? 95   ASN B OD1   1 ? 
ATOM   5503  O  OD1   B ASN B 1 95  ? -34.369 -1.874  -72.272  0.5  36.433  ? 95   ASN B OD1   1 ? 
ATOM   5504  N  ND2   A ASN B 1 95  ? -32.203 0.624   -68.251  0.5  41.557  ? 95   ASN B ND2   1 ? 
ATOM   5505  N  ND2   B ASN B 1 95  ? -33.859 -2.966  -70.374  0.5  39.816  ? 95   ASN B ND2   1 ? 
ATOM   5506  N  N     . GLN B 1 96  ? -29.537 -0.71   -70.473  1    45.487  ? 96   GLN B N     1 ? 
ATOM   5507  C  CA    . GLN B 1 96  ? -28.237 -0.194  -70.068  1    47.456  ? 96   GLN B CA    1 ? 
ATOM   5508  C  C     . GLN B 1 96  ? -27.393 0.185   -71.296  1    41.925  ? 96   GLN B C     1 ? 
ATOM   5509  O  O     . GLN B 1 96  ? -26.702 1.195   -71.279  1    36.673  ? 96   GLN B O     1 ? 
ATOM   5510  C  CB    . GLN B 1 96  ? -27.544 -1.17   -69.116  1    54.974  ? 96   GLN B CB    1 ? 
ATOM   5511  C  CG    . GLN B 1 96  ? -26.152 -0.718  -68.68   1    75.594  ? 96   GLN B CG    1 ? 
ATOM   5512  C  CD    . GLN B 1 96  ? -25.496 -1.63   -67.663  1    91.848  ? 96   GLN B CD    1 ? 
ATOM   5513  O  OE1   . GLN B 1 96  ? -24.953 -2.693  -67.99   1    94.646  ? 96   GLN B OE1   1 ? 
ATOM   5514  N  NE2   . GLN B 1 96  ? -25.525 -1.2    -66.409  1    99.317  ? 96   GLN B NE2   1 ? 
ATOM   5515  N  N     . GLN B 1 97  ? -27.413 -0.629  -72.359  1    37.62   ? 97   GLN B N     1 ? 
ATOM   5516  C  CA    . GLN B 1 97  ? -26.681 -0.27   -73.568  1    36.157  ? 97   GLN B CA    1 ? 
ATOM   5517  C  C     . GLN B 1 97  ? -27.184 1.056   -74.152  1    33.54   ? 97   GLN B C     1 ? 
ATOM   5518  O  O     . GLN B 1 97  ? -26.388 1.893   -74.582  1    32.043  ? 97   GLN B O     1 ? 
ATOM   5519  C  CB    . GLN B 1 97  ? -26.805 -1.391  -74.596  1    40.323  ? 97   GLN B CB    1 ? 
ATOM   5520  C  CG    . GLN B 1 97  ? -25.918 -2.598  -74.298  1    40.849  ? 97   GLN B CG    1 ? 
ATOM   5521  C  CD    . GLN B 1 97  ? -26.057 -3.71   -75.32   1    43.66   ? 97   GLN B CD    1 ? 
ATOM   5522  O  OE1   . GLN B 1 97  ? -27.128 -3.916  -75.905  1    41.596  ? 97   GLN B OE1   1 ? 
ATOM   5523  N  NE2   . GLN B 1 97  ? -24.991 -4.483  -75.48   1    47.835  ? 97   GLN B NE2   1 ? 
ATOM   5524  N  N     . ARG B 1 98  ? -28.509 1.252   -74.146  1    37.121  ? 98   ARG B N     1 ? 
ATOM   5525  C  CA    . ARG B 1 98  ? -29.144 2.465   -74.649  1    37.895  ? 98   ARG B CA    1 ? 
ATOM   5526  C  C     . ARG B 1 98  ? -28.666 3.669   -73.827  1    40.397  ? 98   ARG B C     1 ? 
ATOM   5527  O  O     . ARG B 1 98  ? -28.153 4.661   -74.362  1    39.108  ? 98   ARG B O     1 ? 
ATOM   5528  C  CB    . ARG B 1 98  ? -30.649 2.22    -74.468  1    37.436  ? 98   ARG B CB    1 ? 
ATOM   5529  C  CG    . ARG B 1 98  ? -31.523 2.968   -75.456  1    38.494  ? 98   ARG B CG    1 ? 
ATOM   5530  C  CD    . ARG B 1 98  ? -32.921 2.39    -75.467  1    33.535  ? 98   ARG B CD    1 ? 
ATOM   5531  N  NE    . ARG B 1 98  ? -33.898 3.366   -74.983  1    38.605  ? 98   ARG B NE    1 ? 
ATOM   5532  C  CZ    . ARG B 1 98  ? -34.442 4.352   -75.705  1    38.026  ? 98   ARG B CZ    1 ? 
ATOM   5533  N  NH1   . ARG B 1 98  ? -34.16  4.487   -76.987  1    38.112  ? 98   ARG B NH1   1 ? 
ATOM   5534  N  NH2   . ARG B 1 98  ? -35.336 5.159   -75.162  1    37.414  ? 98   ARG B NH2   1 ? 
ATOM   5535  N  N     . GLY B 1 99  ? -28.817 3.55    -72.501  1    40.478  ? 99   GLY B N     1 ? 
ATOM   5536  C  CA    . GLY B 1 99  ? -28.321 4.539   -71.558  1    39.513  ? 99   GLY B CA    1 ? 
ATOM   5537  C  C     . GLY B 1 99  ? -26.921 5.009   -71.938  1    41.174  ? 99   GLY B C     1 ? 
ATOM   5538  O  O     . GLY B 1 99  ? -26.704 6.202   -72.11   1    43.737  ? 99   GLY B O     1 ? 
ATOM   5539  N  N     . ARG B 1 100 ? -25.983 4.069   -72.114  1    37.63   ? 100  ARG B N     1 ? 
ATOM   5540  C  CA    . ARG B 1 100 ? -24.587 4.444   -72.311  1    42.932  ? 100  ARG B CA    1 ? 
ATOM   5541  C  C     . ARG B 1 100 ? -24.424 5.185   -73.631  1    41.106  ? 100  ARG B C     1 ? 
ATOM   5542  O  O     . ARG B 1 100 ? -23.537 6.042   -73.779  1    35.248  ? 100  ARG B O     1 ? 
ATOM   5543  C  CB    . ARG B 1 100 ? -23.622 3.252   -72.339  1    46.528  ? 100  ARG B CB    1 ? 
ATOM   5544  C  CG    . ARG B 1 100 ? -23.124 2.821   -70.969  1    59.126  ? 100  ARG B CG    1 ? 
ATOM   5545  C  CD    . ARG B 1 100 ? -22.153 1.652   -71.048  1    72.052  ? 100  ARG B CD    1 ? 
ATOM   5546  N  NE    . ARG B 1 100 ? -22.894 0.433   -71.396  1    82.452  ? 100  ARG B NE    1 ? 
ATOM   5547  C  CZ    . ARG B 1 100 ? -23.057 -0.647  -70.629  1    79.19   ? 100  ARG B CZ    1 ? 
ATOM   5548  N  NH1   . ARG B 1 100 ? -22.484 -0.702  -69.435  1    73.976  ? 100  ARG B NH1   1 ? 
ATOM   5549  N  NH2   . ARG B 1 100 ? -23.79  -1.664  -71.071  1    64.246  ? 100  ARG B NH2   1 ? 
ATOM   5550  N  N     . ARG B 1 101 ? -25.287 4.828   -74.588  1    37.293  ? 101  ARG B N     1 ? 
ATOM   5551  C  CA    . ARG B 1 101 ? -25.127 5.338   -75.941  1    38.263  ? 101  ARG B CA    1 ? 
ATOM   5552  C  C     . ARG B 1 101 ? -25.701 6.749   -76.005  1    33.357  ? 101  ARG B C     1 ? 
ATOM   5553  O  O     . ARG B 1 101 ? -25.137 7.629   -76.656  1    35.21   ? 101  ARG B O     1 ? 
ATOM   5554  C  CB    . ARG B 1 101 ? -25.697 4.352   -76.975  1    41.297  ? 101  ARG B CB    1 ? 
ATOM   5555  C  CG    . ARG B 1 101 ? -24.757 3.184   -77.265  1    40.7    ? 101  ARG B CG    1 ? 
ATOM   5556  C  CD    . ARG B 1 101 ? -25.45  1.963   -77.878  1    39.436  ? 101  ARG B CD    1 ? 
ATOM   5557  N  NE    . ARG B 1 101 ? -24.475 0.914   -78.208  1    33.727  ? 101  ARG B NE    1 ? 
ATOM   5558  C  CZ    . ARG B 1 101 ? -23.834 0.207   -77.263  1    37.152  ? 101  ARG B CZ    1 ? 
ATOM   5559  N  NH1   . ARG B 1 101 ? -24.161 0.368   -75.985  1    33.773  ? 101  ARG B NH1   1 ? 
ATOM   5560  N  NH2   . ARG B 1 101 ? -22.92  -0.689  -77.593  1    34.193  ? 101  ARG B NH2   1 ? 
ATOM   5561  N  N     . PHE B 1 102 ? -26.837 6.938   -75.339  1    35.014  ? 102  PHE B N     1 ? 
ATOM   5562  C  CA    . PHE B 1 102 ? -27.415 8.258   -75.17   1    35.807  ? 102  PHE B CA    1 ? 
ATOM   5563  C  C     . PHE B 1 102 ? -26.416 9.152   -74.442  1    36.93   ? 102  PHE B C     1 ? 
ATOM   5564  O  O     . PHE B 1 102 ? -26.048 10.196  -74.962  1    38.185  ? 102  PHE B O     1 ? 
ATOM   5565  C  CB    . PHE B 1 102 ? -28.761 8.139   -74.456  1    35.258  ? 102  PHE B CB    1 ? 
ATOM   5566  C  CG    . PHE B 1 102 ? -29.924 7.886   -75.407  1    38.806  ? 102  PHE B CG    1 ? 
ATOM   5567  C  CD1   . PHE B 1 102 ? -30.045 6.671   -76.091  1    39.514  ? 102  PHE B CD1   1 ? 
ATOM   5568  C  CD2   . PHE B 1 102 ? -30.919 8.849   -75.596  1    37.82   ? 102  PHE B CD2   1 ? 
ATOM   5569  C  CE1   . PHE B 1 102 ? -31.118 6.432   -76.953  1    37.372  ? 102  PHE B CE1   1 ? 
ATOM   5570  C  CE2   . PHE B 1 102 ? -31.993 8.606   -76.462  1    39.54   ? 102  PHE B CE2   1 ? 
ATOM   5571  C  CZ    . PHE B 1 102 ? -32.089 7.397   -77.14   1    36.357  ? 102  PHE B CZ    1 ? 
ATOM   5572  N  N     . ARG B 1 103 ? -25.975 8.723   -73.249  1    42.032  ? 103  ARG B N     1 ? 
ATOM   5573  C  CA    A ARG B 1 103 ? -25.024 9.483   -72.449  0.5  44.208  ? 103  ARG B CA    1 ? 
ATOM   5574  C  CA    B ARG B 1 103 ? -25.016 9.475   -72.447  0.5  43.916  ? 103  ARG B CA    1 ? 
ATOM   5575  C  C     . ARG B 1 103 ? -23.822 9.875   -73.309  1    44.159  ? 103  ARG B C     1 ? 
ATOM   5576  O  O     . ARG B 1 103 ? -23.431 11.038  -73.326  1    45.119  ? 103  ARG B O     1 ? 
ATOM   5577  C  CB    A ARG B 1 103 ? -24.595 8.697   -71.201  0.5  46.043  ? 103  ARG B CB    1 ? 
ATOM   5578  C  CB    B ARG B 1 103 ? -24.529 8.736   -71.19   0.5  45.245  ? 103  ARG B CB    1 ? 
ATOM   5579  C  CG    A ARG B 1 103 ? -24.125 9.517   -70.006  0.5  48.801  ? 103  ARG B CG    1 ? 
ATOM   5580  C  CG    B ARG B 1 103 ? -23.257 9.347   -70.611  0.5  46.155  ? 103  ARG B CG    1 ? 
ATOM   5581  C  CD    A ARG B 1 103 ? -23.246 8.728   -69.045  0.5  48.895  ? 103  ARG B CD    1 ? 
ATOM   5582  C  CD    B ARG B 1 103 ? -22.589 8.703   -69.39   0.5  52.366  ? 103  ARG B CD    1 ? 
ATOM   5583  N  NE    A ARG B 1 103 ? -23.783 7.395   -68.751  0.5  49.107  ? 103  ARG B NE    1 ? 
ATOM   5584  N  NE    B ARG B 1 103 ? -21.293 9.344   -69.121  0.5  50.958  ? 103  ARG B NE    1 ? 
ATOM   5585  C  CZ    A ARG B 1 103 ? -23.184 6.228   -68.974  0.5  44.713  ? 103  ARG B CZ    1 ? 
ATOM   5586  C  CZ    B ARG B 1 103 ? -20.37  8.988   -68.231  0.5  55.676  ? 103  ARG B CZ    1 ? 
ATOM   5587  N  NH1   A ARG B 1 103 ? -21.949 6.192   -69.445  0.5  45.3    ? 103  ARG B NH1   1 ? 
ATOM   5588  N  NH1   B ARG B 1 103 ? -19.223 9.646   -68.183  0.5  52.816  ? 103  ARG B NH1   1 ? 
ATOM   5589  N  NH2   A ARG B 1 103 ? -23.832 5.104   -68.714  0.5  41.866  ? 103  ARG B NH2   1 ? 
ATOM   5590  N  NH2   B ARG B 1 103 ? -20.578 7.971   -67.407  0.5  61.199  ? 103  ARG B NH2   1 ? 
ATOM   5591  N  N     . SER B 1 104 ? -23.256 8.902   -74.04   1    38.205  ? 104  SER B N     1 ? 
ATOM   5592  C  CA    . SER B 1 104 ? -22.029 9.094   -74.807  1    45.088  ? 104  SER B CA    1 ? 
ATOM   5593  C  C     . SER B 1 104 ? -22.149 10.151  -75.913  1    44.535  ? 104  SER B C     1 ? 
ATOM   5594  O  O     . SER B 1 104 ? -21.207 10.908  -76.141  1    39.509  ? 104  SER B O     1 ? 
ATOM   5595  C  CB    . SER B 1 104 ? -21.542 7.79    -75.384  1    45.674  ? 104  SER B CB    1 ? 
ATOM   5596  O  OG    . SER B 1 104 ? -20.305 7.998   -76.034  1    45.629  ? 104  SER B OG    1 ? 
ATOM   5597  N  N     . ALA B 1 105 ? -23.28  10.161  -76.631  1    41.285  ? 105  ALA B N     1 ? 
ATOM   5598  C  CA    . ALA B 1 105 ? -23.511 11.09   -77.729  1    39.805  ? 105  ALA B CA    1 ? 
ATOM   5599  C  C     . ALA B 1 105 ? -23.631 12.505  -77.158  1    46.344  ? 105  ALA B C     1 ? 
ATOM   5600  O  O     . ALA B 1 105 ? -22.953 13.418  -77.631  1    45.403  ? 105  ALA B O     1 ? 
ATOM   5601  C  CB    . ALA B 1 105 ? -24.78  10.707  -78.489  1    35.343  ? 105  ALA B CB    1 ? 
ATOM   5602  N  N     . LYS B 1 106 ? -24.473 12.643  -76.116  1    44.998  ? 106  LYS B N     1 ? 
ATOM   5603  C  CA    . LYS B 1 106 ? -24.75  13.904  -75.44   1    48.307  ? 106  LYS B CA    1 ? 
ATOM   5604  C  C     . LYS B 1 106 ? -23.451 14.514  -74.908  1    46.185  ? 106  LYS B C     1 ? 
ATOM   5605  O  O     . LYS B 1 106 ? -23.215 15.704  -75.092  1    48.482  ? 106  LYS B O     1 ? 
ATOM   5606  C  CB    . LYS B 1 106 ? -25.808 13.752  -74.339  1    47.998  ? 106  LYS B CB    1 ? 
ATOM   5607  C  CG    . LYS B 1 106 ? -26.37  15.087  -73.847  1    59.711  ? 106  LYS B CG    1 ? 
ATOM   5608  C  CD    . LYS B 1 106 ? -27.486 15.06   -72.807  1    73.003  ? 106  LYS B CD    1 ? 
ATOM   5609  C  CE    . LYS B 1 106 ? -26.998 14.787  -71.416  1    88.81   ? 106  LYS B CE    1 ? 
ATOM   5610  N  NZ    . LYS B 1 106 ? -28.09  14.765  -70.435  1    93.864  ? 106  LYS B NZ    1 ? 
ATOM   5611  N  N     . GLU B 1 107 ? -22.582 13.686  -74.318  1    44.486  ? 107  GLU B N     1 ? 
ATOM   5612  C  CA    . GLU B 1 107 ? -21.356 14.153  -73.679  1    49.868  ? 107  GLU B CA    1 ? 
ATOM   5613  C  C     . GLU B 1 107 ? -20.368 14.639  -74.738  1    54.36   ? 107  GLU B C     1 ? 
ATOM   5614  O  O     . GLU B 1 107 ? -19.67  15.631  -74.529  1    55.8    ? 107  GLU B O     1 ? 
ATOM   5615  C  CB    . GLU B 1 107 ? -20.822 13.173  -72.624  1    61.181  ? 107  GLU B CB    1 ? 
ATOM   5616  C  CG    . GLU B 1 107 ? -21.666 13.138  -71.342  1    83.065  ? 107  GLU B CG    1 ? 
ATOM   5617  C  CD    . GLU B 1 107 ? -21.383 12.175  -70.185  1    98.477  ? 107  GLU B CD    1 ? 
ATOM   5618  O  OE1   . GLU B 1 107 ? -20.351 11.462  -70.23   1    103.369 ? 107  GLU B OE1   1 ? 
ATOM   5619  O  OE2   . GLU B 1 107 ? -22.21  12.111  -69.232  1    90.49   ? 107  GLU B OE2   1 ? 
ATOM   5620  N  N     . ALA B 1 108 ? -20.337 13.966  -75.895  1    50.591  ? 108  ALA B N     1 ? 
ATOM   5621  C  CA    . ALA B 1 108 ? -19.452 14.398  -76.971  1    48.665  ? 108  ALA B CA    1 ? 
ATOM   5622  C  C     . ALA B 1 108 ? -19.952 15.679  -77.661  1    45.672  ? 108  ALA B C     1 ? 
ATOM   5623  O  O     . ALA B 1 108 ? -19.141 16.497  -78.113  1    41.281  ? 108  ALA B O     1 ? 
ATOM   5624  C  CB    . ALA B 1 108 ? -19.217 13.269  -77.95   1    49.557  ? 108  ALA B CB    1 ? 
ATOM   5625  N  N     . GLU B 1 109 ? -21.28  15.848  -77.756  1    42.912  ? 109  GLU B N     1 ? 
ATOM   5626  C  CA    . GLU B 1 109 ? -21.888 17.027  -78.371  1    46.563  ? 109  GLU B CA    1 ? 
ATOM   5627  C  C     . GLU B 1 109 ? -21.704 18.236  -77.455  1    48.466  ? 109  GLU B C     1 ? 
ATOM   5628  O  O     . GLU B 1 109 ? -21.467 19.34   -77.942  1    49.075  ? 109  GLU B O     1 ? 
ATOM   5629  C  CB    . GLU B 1 109 ? -23.398 16.917  -78.6    1    55.416  ? 109  GLU B CB    1 ? 
ATOM   5630  C  CG    . GLU B 1 109 ? -23.806 16.217  -79.897  1    66.12   ? 109  GLU B CG    1 ? 
ATOM   5631  C  CD    . GLU B 1 109 ? -25.316 16.011  -80.001  1    76.164  ? 109  GLU B CD    1 ? 
ATOM   5632  O  OE1   . GLU B 1 109 ? -26.024 16.24   -78.993  1    73.451  ? 109  GLU B OE1   1 ? 
ATOM   5633  O  OE2   . GLU B 1 109 ? -25.802 15.643  -81.095  1    78.968  ? 109  GLU B OE2   1 ? 
ATOM   5634  N  N     . ASP B 1 110 ? -21.814 17.995  -76.137  1    46.042  ? 110  ASP B N     1 ? 
ATOM   5635  C  CA    . ASP B 1 110 ? -21.579 18.991  -75.102  1    49.631  ? 110  ASP B CA    1 ? 
ATOM   5636  C  C     . ASP B 1 110 ? -20.139 19.497  -75.177  1    54.068  ? 110  ASP B C     1 ? 
ATOM   5637  O  O     . ASP B 1 110 ? -19.919 20.708  -75.115  1    50.358  ? 110  ASP B O     1 ? 
ATOM   5638  C  CB    . ASP B 1 110 ? -22.043 18.526  -73.727  1    50.052  ? 110  ASP B CB    1 ? 
ATOM   5639  C  CG    . ASP B 1 110 ? -23.555 18.523  -73.5    1    66.096  ? 110  ASP B CG    1 ? 
ATOM   5640  O  OD1   . ASP B 1 110 ? -24.317 18.781  -74.468  1    61.358  ? 110  ASP B OD1   1 ? 
ATOM   5641  O  OD2   . ASP B 1 110 ? -23.98  18.269  -72.348  1    75.183  ? 110  ASP B OD2   1 ? 
ATOM   5642  N  N     . LYS B 1 111 ? -19.172 18.577  -75.34   1    51.452  ? 111  LYS B N     1 ? 
ATOM   5643  C  CA    . LYS B 1 111 ? -17.767 18.951  -75.379  1    51.574  ? 111  LYS B CA    1 ? 
ATOM   5644  C  C     . LYS B 1 111 ? -17.453 19.767  -76.637  1    54.999  ? 111  LYS B C     1 ? 
ATOM   5645  O  O     . LYS B 1 111 ? -16.591 20.654  -76.589  1    47.767  ? 111  LYS B O     1 ? 
ATOM   5646  C  CB    . LYS B 1 111 ? -16.816 17.763  -75.198  1    54.848  ? 111  LYS B CB    1 ? 
ATOM   5647  C  CG    . LYS B 1 111 ? -16.899 16.996  -73.875  1    60.148  ? 111  LYS B CG    1 ? 
ATOM   5648  C  CD    . LYS B 1 111 ? -15.859 15.878  -73.853  1    59.581  ? 111  LYS B CD    1 ? 
ATOM   5649  C  CE    . LYS B 1 111 ? -16.247 14.607  -73.139  1    73.565  ? 111  LYS B CE    1 ? 
ATOM   5650  N  NZ    . LYS B 1 111 ? -16.263 14.679  -71.676  1    83.563  ? 111  LYS B NZ    1 ? 
ATOM   5651  N  N     . ILE B 1 112 ? -18.132 19.435  -77.751  1    53.546  ? 112  ILE B N     1 ? 
ATOM   5652  C  CA    . ILE B 1 112 ? -17.973 20.113  -79.035  1    49.396  ? 112  ILE B CA    1 ? 
ATOM   5653  C  C     . ILE B 1 112 ? -18.465 21.561  -78.897  1    50.584  ? 112  ILE B C     1 ? 
ATOM   5654  O  O     . ILE B 1 112 ? -17.746 22.495  -79.248  1    49.09   ? 112  ILE B O     1 ? 
ATOM   5655  C  CB    . ILE B 1 112 ? -18.697 19.342  -80.168  1    47.874  ? 112  ILE B CB    1 ? 
ATOM   5656  C  CG1   . ILE B 1 112 ? -17.874 18.107  -80.645  1    49.941  ? 112  ILE B CG1   1 ? 
ATOM   5657  C  CG2   . ILE B 1 112 ? -19.057 20.258  -81.341  1    41.906  ? 112  ILE B CG2   1 ? 
ATOM   5658  C  CD1   . ILE B 1 112 ? -18.37  17.449  -81.923  1    53.641  ? 112  ILE B CD1   1 ? 
ATOM   5659  N  N     . LYS B 1 113 ? -19.7   21.716  -78.393  1    45.673  ? 113  LYS B N     1 ? 
ATOM   5660  C  CA    . LYS B 1 113 ? -20.331 22.995  -78.104  1    53.587  ? 113  LYS B CA    1 ? 
ATOM   5661  C  C     . LYS B 1 113 ? -19.395 23.84   -77.236  1    55.863  ? 113  LYS B C     1 ? 
ATOM   5662  O  O     . LYS B 1 113 ? -19.184 25.01   -77.546  1    56.756  ? 113  LYS B O     1 ? 
ATOM   5663  C  CB    . LYS B 1 113 ? -21.705 22.778  -77.46   1    52.34   ? 113  LYS B CB    1 ? 
ATOM   5664  C  CG    . LYS B 1 113 ? -22.195 23.964  -76.64   1    68.676  ? 113  LYS B CG    1 ? 
ATOM   5665  C  CD    . LYS B 1 113 ? -23.262 23.64   -75.599  1    78.528  ? 113  LYS B CD    1 ? 
ATOM   5666  C  CE    . LYS B 1 113 ? -22.75  22.829  -74.445  1    84.815  ? 113  LYS B CE    1 ? 
ATOM   5667  N  NZ    . LYS B 1 113 ? -23.81  22.489  -73.491  1    88.624  ? 113  LYS B NZ    1 ? 
ATOM   5668  N  N     . LYS B 1 114 ? -18.796 23.224  -76.198  1    48.444  ? 114  LYS B N     1 ? 
ATOM   5669  C  CA    . LYS B 1 114 ? -17.841 23.909  -75.34   1    48.673  ? 114  LYS B CA    1 ? 
ATOM   5670  C  C     . LYS B 1 114 ? -16.652 24.413  -76.148  1    55.024  ? 114  LYS B C     1 ? 
ATOM   5671  O  O     . LYS B 1 114 ? -16.227 25.548  -75.948  1    54.998  ? 114  LYS B O     1 ? 
ATOM   5672  C  CB    . LYS B 1 114 ? -17.317 23.15   -74.115  1    52.02   ? 114  LYS B CB    1 ? 
ATOM   5673  C  CG    . LYS B 1 114 ? -18.295 23.042  -72.964  1    58.631  ? 114  LYS B CG    1 ? 
ATOM   5674  C  CD    . LYS B 1 114 ? -17.718 22.432  -71.693  1    63.297  ? 114  LYS B CD    1 ? 
ATOM   5675  C  CE    . LYS B 1 114 ? -18.793 22.423  -70.656  1    74.148  ? 114  LYS B CE    1 ? 
ATOM   5676  N  NZ    . LYS B 1 114 ? -18.37  21.723  -69.439  1    81.012  ? 114  LYS B NZ    1 ? 
ATOM   5677  N  N     . ALA B 1 115 ? -16.113 23.569  -77.037  1    57.964  ? 115  ALA B N     1 ? 
ATOM   5678  C  CA    . ALA B 1 115 ? -14.901 23.915  -77.77   1    62.238  ? 115  ALA B CA    1 ? 
ATOM   5679  C  C     . ALA B 1 115 ? -15.18  25.112  -78.68   1    65.898  ? 115  ALA B C     1 ? 
ATOM   5680  O  O     . ALA B 1 115 ? -14.314 25.964  -78.902  1    58.3    ? 115  ALA B O     1 ? 
ATOM   5681  C  CB    . ALA B 1 115 ? -14.408 22.727  -78.569  1    59.416  ? 115  ALA B CB    1 ? 
ATOM   5682  N  N     . ILE B 1 116 ? -16.412 25.147  -79.196  1    60.85   ? 116  ILE B N     1 ? 
ATOM   5683  C  CA    . ILE B 1 116 ? -16.884 26.178  -80.103  1    65.77   ? 116  ILE B CA    1 ? 
ATOM   5684  C  C     . ILE B 1 116 ? -17.028 27.494  -79.335  1    63.618  ? 116  ILE B C     1 ? 
ATOM   5685  O  O     . ILE B 1 116 ? -16.586 28.54   -79.806  1    64.439  ? 116  ILE B O     1 ? 
ATOM   5686  C  CB    . ILE B 1 116 ? -18.196 25.719  -80.766  1    59.689  ? 116  ILE B CB    1 ? 
ATOM   5687  C  CG1   . ILE B 1 116 ? -17.937 24.558  -81.736  1    67.316  ? 116  ILE B CG1   1 ? 
ATOM   5688  C  CG2   . ILE B 1 116 ? -18.908 26.881  -81.454  1    53.584  ? 116  ILE B CG2   1 ? 
ATOM   5689  C  CD1   . ILE B 1 116 ? -19.181 23.766  -82.098  1    74.951  ? 116  ILE B CD1   1 ? 
ATOM   5690  N  N     . GLU B 1 117 ? -17.612 27.414  -78.136  1    60.361  ? 117  GLU B N     1 ? 
ATOM   5691  C  CA    . GLU B 1 117 ? -17.822 28.58   -77.295  1    65.099  ? 117  GLU B CA    1 ? 
ATOM   5692  C  C     . GLU B 1 117 ? -16.5   29.266  -76.955  1    69.825  ? 117  GLU B C     1 ? 
ATOM   5693  O  O     . GLU B 1 117 ? -16.519 30.445  -76.609  1    79.306  ? 117  GLU B O     1 ? 
ATOM   5694  C  CB    . GLU B 1 117 ? -18.62  28.276  -76.026  1    66.781  ? 117  GLU B CB    1 ? 
ATOM   5695  C  CG    . GLU B 1 117 ? -20.114 28.063  -76.264  1    70.585  ? 117  GLU B CG    1 ? 
ATOM   5696  C  CD    . GLU B 1 117 ? -20.933 27.735  -75.017  1    85.978  ? 117  GLU B CD    1 ? 
ATOM   5697  O  OE1   . GLU B 1 117 ? -21.836 28.543  -74.7    1    94.783  ? 117  GLU B OE1   1 ? 
ATOM   5698  O  OE2   . GLU B 1 117 ? -20.69  26.693  -74.354  1    82.866  ? 117  GLU B OE2   1 ? 
ATOM   5699  N  N     . LYS B 1 118 ? -15.368 28.547  -77.042  1    65.767  ? 118  LYS B N     1 ? 
ATOM   5700  C  CA    . LYS B 1 118 ? -14.075 29.176  -76.796  1    63.396  ? 118  LYS B CA    1 ? 
ATOM   5701  C  C     . LYS B 1 118 ? -13.344 29.411  -78.113  1    67.333  ? 118  LYS B C     1 ? 
ATOM   5702  O  O     . LYS B 1 118 ? -12.117 29.55   -78.138  1    66.905  ? 118  LYS B O     1 ? 
ATOM   5703  C  CB    . LYS B 1 118 ? -13.234 28.559  -75.67   1    66.436  ? 118  LYS B CB    1 ? 
ATOM   5704  C  CG    . LYS B 1 118 ? -12.619 27.185  -75.857  1    69.054  ? 118  LYS B CG    1 ? 
ATOM   5705  C  CD    . LYS B 1 118 ? -12.333 26.495  -74.528  1    71.619  ? 118  LYS B CD    1 ? 
ATOM   5706  C  CE    . LYS B 1 118 ? -13.621 26.357  -73.766  1    80.959  ? 118  LYS B CE    1 ? 
ATOM   5707  N  NZ    . LYS B 1 118 ? -13.517 25.517  -72.57   1    94.648  ? 118  LYS B NZ    1 ? 
ATOM   5708  N  N     . GLY B 1 119 ? -14.139 29.473  -79.19   1    66.719  ? 119  GLY B N     1 ? 
ATOM   5709  C  CA    . GLY B 1 119 ? -13.705 29.902  -80.511  1    69.982  ? 119  GLY B CA    1 ? 
ATOM   5710  C  C     . GLY B 1 119 ? -12.629 29      -81.112  1    77.482  ? 119  GLY B C     1 ? 
ATOM   5711  O  O     . GLY B 1 119 ? -11.844 29.449  -81.949  1    83.221  ? 119  GLY B O     1 ? 
ATOM   5712  N  N     . GLU B 1 120 ? -12.592 27.733  -80.677  1    81.109  ? 120  GLU B N     1 ? 
ATOM   5713  C  CA    . GLU B 1 120 ? -11.695 26.753  -81.273  1    70.686  ? 120  GLU B CA    1 ? 
ATOM   5714  C  C     . GLU B 1 120 ? -12.304 26.277  -82.591  1    69.925  ? 120  GLU B C     1 ? 
ATOM   5715  O  O     . GLU B 1 120 ? -13.532 26.31   -82.758  1    55.221  ? 120  GLU B O     1 ? 
ATOM   5716  C  CB    . GLU B 1 120 ? -11.449 25.556  -80.356  1    63.408  ? 120  GLU B CB    1 ? 
ATOM   5717  C  CG    . GLU B 1 120 ? -10.916 25.915  -78.972  1    71.113  ? 120  GLU B CG    1 ? 
ATOM   5718  C  CD    . GLU B 1 120 ? -10.534 24.658  -78.204  1    74.965  ? 120  GLU B CD    1 ? 
ATOM   5719  O  OE1   . GLU B 1 120 ? -9.342  24.484  -77.862  1    72.576  ? 120  GLU B OE1   1 ? 
ATOM   5720  O  OE2   . GLU B 1 120 ? -11.438 23.826  -77.985  1    69.814  ? 120  GLU B OE2   1 ? 
ATOM   5721  N  N     . THR B 1 121 ? -11.427 25.838  -83.51   1    63.118  ? 121  THR B N     1 ? 
ATOM   5722  C  CA    . THR B 1 121 ? -11.851 25.345  -84.813  1    80.797  ? 121  THR B CA    1 ? 
ATOM   5723  C  C     . THR B 1 121 ? -11.599 23.833  -84.955  1    80.703  ? 121  THR B C     1 ? 
ATOM   5724  O  O     . THR B 1 121 ? -10.453 23.366  -84.982  1    72.661  ? 121  THR B O     1 ? 
ATOM   5725  C  CB    . THR B 1 121 ? -11.23  26.198  -85.922  1    88.868  ? 121  THR B CB    1 ? 
ATOM   5726  O  OG1   . THR B 1 121 ? -11.944 25.773  -87.079  1    93.185  ? 121  THR B OG1   1 ? 
ATOM   5727  C  CG2   . THR B 1 121 ? -9.721  26.058  -86.05   1    92.849  ? 121  THR B CG2   1 ? 
ATOM   5728  N  N     . LEU B 1 122 ? -12.707 23.082  -85.07   1    77.125  ? 122  LEU B N     1 ? 
ATOM   5729  C  CA    . LEU B 1 122 ? -12.738 21.623  -85.06   1    73.839  ? 122  LEU B CA    1 ? 
ATOM   5730  C  C     . LEU B 1 122 ? -12.114 21.073  -86.34   1    70.909  ? 122  LEU B C     1 ? 
ATOM   5731  O  O     . LEU B 1 122 ? -12.07  21.777  -87.347  1    73.906  ? 122  LEU B O     1 ? 
ATOM   5732  C  CB    . LEU B 1 122 ? -14.196 21.176  -84.953  1    66.771  ? 122  LEU B CB    1 ? 
ATOM   5733  C  CG    . LEU B 1 122 ? -14.971 21.685  -83.735  1    77.39   ? 122  LEU B CG    1 ? 
ATOM   5734  C  CD1   . LEU B 1 122 ? -16.474 21.486  -83.916  1    78.644  ? 122  LEU B CD1   1 ? 
ATOM   5735  C  CD2   . LEU B 1 122 ? -14.464 21.039  -82.445  1    62.997  ? 122  LEU B CD2   1 ? 
ATOM   5736  N  N     . PRO B 1 123 ? -11.632 19.803  -86.363  1    71.014  ? 123  PRO B N     1 ? 
ATOM   5737  C  CA    . PRO B 1 123 ? -11.254 19.166  -87.623  1    62.552  ? 123  PRO B CA    1 ? 
ATOM   5738  C  C     . PRO B 1 123 ? -12.52  19.134  -88.47   1    63.723  ? 123  PRO B C     1 ? 
ATOM   5739  O  O     . PRO B 1 123 ? -13.637 19.24   -87.949  1    59.944  ? 123  PRO B O     1 ? 
ATOM   5740  C  CB    . PRO B 1 123 ? -10.77  17.77   -87.218  1    59.452  ? 123  PRO B CB    1 ? 
ATOM   5741  C  CG    . PRO B 1 123 ? -10.365 17.953  -85.776  1    60.462  ? 123  PRO B CG    1 ? 
ATOM   5742  C  CD    . PRO B 1 123 ? -11.391 18.928  -85.202  1    62.439  ? 123  PRO B CD    1 ? 
ATOM   5743  N  N     . THR B 1 124 ? -12.31  19.022  -89.781  1    60.507  ? 124  THR B N     1 ? 
ATOM   5744  C  CA    . THR B 1 124 ? -13.394 19.045  -90.742  1    66.072  ? 124  THR B CA    1 ? 
ATOM   5745  C  C     . THR B 1 124 ? -14.034 17.652  -90.869  1    67.23   ? 124  THR B C     1 ? 
ATOM   5746  O  O     . THR B 1 124 ? -15.264 17.545  -90.843  1    60.84   ? 124  THR B O     1 ? 
ATOM   5747  C  CB    . THR B 1 124 ? -12.868 19.685  -92.033  1    70.598  ? 124  THR B CB    1 ? 
ATOM   5748  O  OG1   . THR B 1 124 ? -13.895 19.63   -93.018  1    79.077  ? 124  THR B OG1   1 ? 
ATOM   5749  C  CG2   . THR B 1 124 ? -11.557 19.088  -92.52   1    66.389  ? 124  THR B CG2   1 ? 
ATOM   5750  N  N     . GLU B 1 125 ? -13.218 16.583  -90.951  1    66.43   ? 125  GLU B N     1 ? 
ATOM   5751  C  CA    . GLU B 1 125 ? -13.755 15.222  -90.976  1    73.933  ? 125  GLU B CA    1 ? 
ATOM   5752  C  C     . GLU B 1 125 ? -14.433 14.914  -89.639  1    66.42   ? 125  GLU B C     1 ? 
ATOM   5753  O  O     . GLU B 1 125 ? -13.933 15.304  -88.588  1    53.318  ? 125  GLU B O     1 ? 
ATOM   5754  C  CB    . GLU B 1 125 ? -12.813 14.085  -91.396  1    78.201  ? 125  GLU B CB    1 ? 
ATOM   5755  C  CG    . GLU B 1 125 ? -11.513 13.997  -90.6    1    86.384  ? 125  GLU B CG    1 ? 
ATOM   5756  C  CD    . GLU B 1 125 ? -10.409 14.902  -91.126  1    96.779  ? 125  GLU B CD    1 ? 
ATOM   5757  O  OE1   . GLU B 1 125 ? -9.911  14.62   -92.238  1    94.034  ? 125  GLU B OE1   1 ? 
ATOM   5758  O  OE2   . GLU B 1 125 ? -10.054 15.892  -90.445  1    95.782  ? 125  GLU B OE2   1 ? 
ATOM   5759  N  N     . ALA B 1 126 ? -15.577 14.216  -89.701  1    67.139  ? 126  ALA B N     1 ? 
ATOM   5760  C  CA    . ALA B 1 126 ? -16.39  13.918  -88.531  1    64.845  ? 126  ALA B CA    1 ? 
ATOM   5761  C  C     . ALA B 1 126 ? -15.606 13.058  -87.539  1    60.663  ? 126  ALA B C     1 ? 
ATOM   5762  O  O     . ALA B 1 126 ? -14.65  12.387  -87.916  1    59.813  ? 126  ALA B O     1 ? 
ATOM   5763  C  CB    . ALA B 1 126 ? -17.677 13.244  -88.957  1    68.952  ? 126  ALA B CB    1 ? 
ATOM   5764  N  N     . ARG B 1 127 ? -16.019 13.109  -86.268  1    58.507  ? 127  ARG B N     1 ? 
ATOM   5765  C  CA    . ARG B 1 127 ? -15.434 12.332  -85.186  1    57.688  ? 127  ARG B CA    1 ? 
ATOM   5766  C  C     . ARG B 1 127 ? -15.723 10.842  -85.403  1    48.958  ? 127  ARG B C     1 ? 
ATOM   5767  O  O     . ARG B 1 127 ? -16.66  10.508  -86.119  1    41.261  ? 127  ARG B O     1 ? 
ATOM   5768  C  CB    . ARG B 1 127 ? -16.208 12.795  -83.949  1    57.404  ? 127  ARG B CB    1 ? 
ATOM   5769  C  CG    . ARG B 1 127 ? -15.691 12.418  -82.572  1    65.154  ? 127  ARG B CG    1 ? 
ATOM   5770  C  CD    . ARG B 1 127 ? -16.523 13.201  -81.569  1    72.209  ? 127  ARG B CD    1 ? 
ATOM   5771  N  NE    . ARG B 1 127 ? -17.957 12.934  -81.736  1    70.245  ? 127  ARG B NE    1 ? 
ATOM   5772  C  CZ    . ARG B 1 127 ? -18.575 11.866  -81.241  1    63.026  ? 127  ARG B CZ    1 ? 
ATOM   5773  N  NH1   . ARG B 1 127 ? -17.903 11.019  -80.469  1    55.059  ? 127  ARG B NH1   1 ? 
ATOM   5774  N  NH2   . ARG B 1 127 ? -19.862 11.679  -81.501  1    56.143  ? 127  ARG B NH2   1 ? 
ATOM   5775  N  N     . PHE B 1 128 ? -14.911 9.962   -84.791  1    41.434  ? 128  PHE B N     1 ? 
ATOM   5776  C  CA    . PHE B 1 128 ? -15.312 8.579   -84.562  1    41.047  ? 128  PHE B CA    1 ? 
ATOM   5777  C  C     . PHE B 1 128 ? -16.454 8.562   -83.536  1    43.744  ? 128  PHE B C     1 ? 
ATOM   5778  O  O     . PHE B 1 128 ? -16.304 9.042   -82.405  1    40.881  ? 128  PHE B O     1 ? 
ATOM   5779  C  CB    . PHE B 1 128 ? -14.105 7.744   -84.121  1    45.299  ? 128  PHE B CB    1 ? 
ATOM   5780  C  CG    . PHE B 1 128 ? -14.395 6.264   -83.878  1    49.591  ? 128  PHE B CG    1 ? 
ATOM   5781  C  CD1   . PHE B 1 128 ? -14.319 5.339   -84.921  1    47.402  ? 128  PHE B CD1   1 ? 
ATOM   5782  C  CD2   . PHE B 1 128 ? -14.728 5.794   -82.607  1    49.678  ? 128  PHE B CD2   1 ? 
ATOM   5783  C  CE1   . PHE B 1 128 ? -14.567 3.996   -84.701  1    43.556  ? 128  PHE B CE1   1 ? 
ATOM   5784  C  CE2   . PHE B 1 128 ? -14.993 4.443   -82.391  1    50.199  ? 128  PHE B CE2   1 ? 
ATOM   5785  C  CZ    . PHE B 1 128 ? -14.902 3.546   -83.438  1    45.273  ? 128  PHE B CZ    1 ? 
ATOM   5786  N  N     . ASP B 1 129 ? -17.628 8.088   -83.969  1    39.459  ? 129  ASP B N     1 ? 
ATOM   5787  C  CA    . ASP B 1 129 ? -18.76  7.952   -83.069  1    40.065  ? 129  ASP B CA    1 ? 
ATOM   5788  C  C     . ASP B 1 129 ? -18.658 6.594   -82.362  1    49.659  ? 129  ASP B C     1 ? 
ATOM   5789  O  O     . ASP B 1 129 ? -18.994 5.555   -82.933  1    45.514  ? 129  ASP B O     1 ? 
ATOM   5790  C  CB    . ASP B 1 129 ? -20.088 8.095   -83.804  1    37.465  ? 129  ASP B CB    1 ? 
ATOM   5791  C  CG    . ASP B 1 129 ? -21.296 7.831   -82.916  1    42.731  ? 129  ASP B CG    1 ? 
ATOM   5792  O  OD1   . ASP B 1 129 ? -21.09  7.619   -81.697  1    45.969  ? 129  ASP B OD1   1 ? 
ATOM   5793  O  OD2   . ASP B 1 129 ? -22.434 7.788   -83.434  1    48.501  ? 129  ASP B OD2   1 ? 
ATOM   5794  N  N     . SER B 1 130 ? -18.215 6.606   -81.098  1    45.446  ? 130  SER B N     1 ? 
ATOM   5795  C  CA    . SER B 1 130 ? -17.97  5.379   -80.366  1    40.725  ? 130  SER B CA    1 ? 
ATOM   5796  C  C     . SER B 1 130 ? -19.227 4.501   -80.272  1    37.409  ? 130  SER B C     1 ? 
ATOM   5797  O  O     . SER B 1 130 ? -19.09  3.304   -80.018  1    35.673  ? 130  SER B O     1 ? 
ATOM   5798  C  CB    . SER B 1 130 ? -17.291 5.641   -79.025  1    38.49   ? 130  SER B CB    1 ? 
ATOM   5799  O  OG    . SER B 1 130 ? -18.196 6.222   -78.103  1    40.681  ? 130  SER B OG    1 ? 
ATOM   5800  N  N     . ASN B 1 131 ? -20.421 5.072   -80.526  1    28.827  ? 131  ASN B N     1 ? 
ATOM   5801  C  CA    . ASN B 1 131 ? -21.669 4.316   -80.609  1    35.392  ? 131  ASN B CA    1 ? 
ATOM   5802  C  C     . ASN B 1 131 ? -21.658 3.352   -81.795  1    37.62   ? 131  ASN B C     1 ? 
ATOM   5803  O  O     . ASN B 1 131 ? -22.549 2.51    -81.909  1    34.352  ? 131  ASN B O     1 ? 
ATOM   5804  C  CB    . ASN B 1 131 ? -22.914 5.19    -80.73   1    33.867  ? 131  ASN B CB    1 ? 
ATOM   5805  C  CG    . ASN B 1 131 ? -23.214 5.908   -79.434  1    39.932  ? 131  ASN B CG    1 ? 
ATOM   5806  O  OD1   . ASN B 1 131 ? -22.616 5.578   -78.398  1    39.722  ? 131  ASN B OD1   1 ? 
ATOM   5807  N  ND2   . ASN B 1 131 ? -24.151 6.852   -79.455  1    35.41   ? 131  ASN B ND2   1 ? 
ATOM   5808  N  N     . CYS B 1 132 ? -20.637 3.466   -82.661  1    36.524  ? 132  CYS B N     1 ? 
ATOM   5809  C  CA    . CYS B 1 132 ? -20.533 2.548   -83.788  1    37.799  ? 132  CYS B CA    1 ? 
ATOM   5810  C  C     . CYS B 1 132 ? -20.007 1.188   -83.318  1    34.697  ? 132  CYS B C     1 ? 
ATOM   5811  O  O     . CYS B 1 132 ? -19.915 0.258   -84.116  1    32.813  ? 132  CYS B O     1 ? 
ATOM   5812  C  CB    . CYS B 1 132 ? -19.674 3.112   -84.914  1    33.061  ? 132  CYS B CB    1 ? 
ATOM   5813  S  SG    . CYS B 1 132 ? -17.905 3.005   -84.559  1    35.784  ? 132  CYS B SG    1 ? 
ATOM   5814  N  N     . ILE B 1 133 ? -19.649 1.081   -82.03   1    33.309  ? 133  ILE B N     1 ? 
ATOM   5815  C  CA    . ILE B 1 133 ? -19.169 -0.182  -81.488  1    34.411  ? 133  ILE B CA    1 ? 
ATOM   5816  C  C     . ILE B 1 133 ? -20.371 -0.88   -80.872  1    35.41   ? 133  ILE B C     1 ? 
ATOM   5817  O  O     . ILE B 1 133 ? -20.48  -0.95   -79.646  1    32.322  ? 133  ILE B O     1 ? 
ATOM   5818  C  CB    . ILE B 1 133 ? -18.022 0.001   -80.474  1    34.085  ? 133  ILE B CB    1 ? 
ATOM   5819  C  CG1   . ILE B 1 133 ? -16.878 0.796   -81.074  1    33.286  ? 133  ILE B CG1   1 ? 
ATOM   5820  C  CG2   . ILE B 1 133 ? -17.534 -1.353  -79.949  1    33.648  ? 133  ILE B CG2   1 ? 
ATOM   5821  C  CD1   . ILE B 1 133 ? -15.893 1.303   -80.044  1    36.62   ? 133  ILE B CD1   1 ? 
ATOM   5822  N  N     . THR B 1 134 ? -21.289 -1.294  -81.762  1    29.679  ? 134  THR B N     1 ? 
ATOM   5823  C  CA    . THR B 1 134 ? -22.538 -1.979  -81.466  1    31.467  ? 134  THR B CA    1 ? 
ATOM   5824  C  C     . THR B 1 134 ? -22.684 -3.024  -82.56   1    39.427  ? 134  THR B C     1 ? 
ATOM   5825  O  O     . THR B 1 134 ? -22.339 -2.733  -83.711  1    37.833  ? 134  THR B O     1 ? 
ATOM   5826  C  CB    . THR B 1 134 ? -23.671 -0.956  -81.547  1    32.288  ? 134  THR B CB    1 ? 
ATOM   5827  O  OG1   . THR B 1 134 ? -23.307 0.104   -80.672  1    34.44   ? 134  THR B OG1   1 ? 
ATOM   5828  C  CG2   . THR B 1 134 ? -25.033 -1.498  -81.152  1    30.776  ? 134  THR B CG2   1 ? 
ATOM   5829  N  N     . PRO B 1 135 ? -23.135 -4.265  -82.266  1    39.585  ? 135  PRO B N     1 ? 
ATOM   5830  C  CA    . PRO B 1 135 ? -23.26  -5.28   -83.32   1    39.878  ? 135  PRO B CA    1 ? 
ATOM   5831  C  C     . PRO B 1 135 ? -24.054 -4.746  -84.507  1    37.843  ? 135  PRO B C     1 ? 
ATOM   5832  O  O     . PRO B 1 135 ? -25.106 -4.137  -84.323  1    40.315  ? 135  PRO B O     1 ? 
ATOM   5833  C  CB    . PRO B 1 135 ? -23.967 -6.472  -82.689  1    41.126  ? 135  PRO B CB    1 ? 
ATOM   5834  C  CG    . PRO B 1 135 ? -24.147 -6.101  -81.22   1    42.766  ? 135  PRO B CG    1 ? 
ATOM   5835  C  CD    . PRO B 1 135 ? -23.493 -4.763  -80.933  1    41.082  ? 135  PRO B CD    1 ? 
ATOM   5836  N  N     . GLY B 1 136 ? -23.522 -4.979  -85.714  1    39.413  ? 136  GLY B N     1 ? 
ATOM   5837  C  CA    . GLY B 1 136 ? -24.296 -4.839  -86.944  1    41.897  ? 136  GLY B CA    1 ? 
ATOM   5838  C  C     . GLY B 1 136 ? -23.97  -3.563  -87.731  1    42.539  ? 136  GLY B C     1 ? 
ATOM   5839  O  O     . GLY B 1 136 ? -24.408 -3.4    -88.868  1    36.601  ? 136  GLY B O     1 ? 
ATOM   5840  N  N     . THR B 1 137 ? -23.2   -2.647  -87.133  1    36.02   ? 137  THR B N     1 ? 
ATOM   5841  C  CA    . THR B 1 137 ? -22.827 -1.444  -87.862  1    36.664  ? 137  THR B CA    1 ? 
ATOM   5842  C  C     . THR B 1 137 ? -21.78  -1.782  -88.916  1    39.055  ? 137  THR B C     1 ? 
ATOM   5843  O  O     . THR B 1 137 ? -21.22  -2.882  -88.943  1    36.235  ? 137  THR B O     1 ? 
ATOM   5844  C  CB    . THR B 1 137 ? -22.349 -0.35   -86.906  1    32.843  ? 137  THR B CB    1 ? 
ATOM   5845  O  OG1   . THR B 1 137 ? -21.085 -0.793  -86.418  1    32.629  ? 137  THR B OG1   1 ? 
ATOM   5846  C  CG2   . THR B 1 137 ? -23.356 -0.078  -85.806  1    34.203  ? 137  THR B CG2   1 ? 
ATOM   5847  N  N     . GLU B 1 138 ? -21.536 -0.801  -89.79   1    37.598  ? 138  GLU B N     1 ? 
ATOM   5848  C  CA    . GLU B 1 138 ? -20.583 -0.957  -90.871  1    39.189  ? 138  GLU B CA    1 ? 
ATOM   5849  C  C     . GLU B 1 138 ? -19.18  -1.088  -90.298  1    37.474  ? 138  GLU B C     1 ? 
ATOM   5850  O  O     . GLU B 1 138 ? -18.389 -1.904  -90.771  1    38.352  ? 138  GLU B O     1 ? 
ATOM   5851  C  CB    . GLU B 1 138 ? -20.625 0.279   -91.774  1    47.898  ? 138  GLU B CB    1 ? 
ATOM   5852  C  CG    . GLU B 1 138 ? -21.763 0.237   -92.789  1    50.375  ? 138  GLU B CG    1 ? 
ATOM   5853  C  CD    . GLU B 1 138 ? -21.676 1.259   -93.919  1    60.234  ? 138  GLU B CD    1 ? 
ATOM   5854  O  OE1   . GLU B 1 138 ? -22.655 2.017   -94.039  1    53.58   ? 138  GLU B OE1   1 ? 
ATOM   5855  O  OE2   . GLU B 1 138 ? -20.676 1.298   -94.679  1    61.583  ? 138  GLU B OE2   1 ? 
ATOM   5856  N  N     . PHE B 1 139 ? -18.874 -0.267  -89.285  1    33.257  ? 139  PHE B N     1 ? 
ATOM   5857  C  CA    . PHE B 1 139 ? -17.586 -0.353  -88.607  1    33.564  ? 139  PHE B CA    1 ? 
ATOM   5858  C  C     . PHE B 1 139 ? -17.367 -1.755  -88.02   1    33.004  ? 139  PHE B C     1 ? 
ATOM   5859  O  O     . PHE B 1 139 ? -16.284 -2.311  -88.147  1    35.211  ? 139  PHE B O     1 ? 
ATOM   5860  C  CB    . PHE B 1 139 ? -17.382 0.764   -87.577  1    32.901  ? 139  PHE B CB    1 ? 
ATOM   5861  C  CG    . PHE B 1 139 ? -16.091 0.592   -86.793  1    36.288  ? 139  PHE B CG    1 ? 
ATOM   5862  C  CD1   . PHE B 1 139 ? -14.892 1.127   -87.27   1    37.651  ? 139  PHE B CD1   1 ? 
ATOM   5863  C  CD2   . PHE B 1 139 ? -16.071 -0.122  -85.595  1    34.351  ? 139  PHE B CD2   1 ? 
ATOM   5864  C  CE1   . PHE B 1 139 ? -13.708 0.971   -86.557  1    35.826  ? 139  PHE B CE1   1 ? 
ATOM   5865  C  CE2   . PHE B 1 139 ? -14.878 -0.294  -84.908  1    37.339  ? 139  PHE B CE2   1 ? 
ATOM   5866  C  CZ    . PHE B 1 139 ? -13.696 0.238   -85.395  1    34.191  ? 139  PHE B CZ    1 ? 
ATOM   5867  N  N     . MET B 1 140 ? -18.38  -2.311  -87.343  1    32.702  ? 140  MET B N     1 ? 
ATOM   5868  C  CA    . MET B 1 140 ? -18.217 -3.612  -86.7    1    36.149  ? 140  MET B CA    1 ? 
ATOM   5869  C  C     . MET B 1 140 ? -18.016 -4.703  -87.759  1    37.991  ? 140  MET B C     1 ? 
ATOM   5870  O  O     . MET B 1 140 ? -17.258 -5.648  -87.535  1    42.541  ? 140  MET B O     1 ? 
ATOM   5871  C  CB    . MET B 1 140 ? -19.355 -3.935  -85.719  1    34.557  ? 140  MET B CB    1 ? 
ATOM   5872  C  CG    . MET B 1 140 ? -19.22  -3.19   -84.388  1    36.524  ? 140  MET B CG    1 ? 
ATOM   5873  S  SD    . MET B 1 140 ? -17.69  -3.549  -83.486  1    35.369  ? 140  MET B SD    1 ? 
ATOM   5874  C  CE    . MET B 1 140 ? -18.624 -4.663  -82.426  1    30.59   ? 140  MET B CE    1 ? 
ATOM   5875  N  N     . ALA B 1 141 ? -18.646 -4.532  -88.931  1    35.962  ? 141  ALA B N     1 ? 
ATOM   5876  C  CA    . ALA B 1 141 ? -18.483 -5.472  -90.038  1    35.715  ? 141  ALA B CA    1 ? 
ATOM   5877  C  C     . ALA B 1 141 ? -17.062 -5.432  -90.602  1    35.693  ? 141  ALA B C     1 ? 
ATOM   5878  O  O     . ALA B 1 141 ? -16.456 -6.479  -90.817  1    40.331  ? 141  ALA B O     1 ? 
ATOM   5879  C  CB    . ALA B 1 141 ? -19.532 -5.237  -91.092  1    32.146  ? 141  ALA B CB    1 ? 
ATOM   5880  N  N     . ARG B 1 142 ? -16.512 -4.231  -90.801  1    35.523  ? 142  ARG B N     1 ? 
ATOM   5881  C  CA    . ARG B 1 142 ? -15.134 -4.087  -91.264  1    38.142  ? 142  ARG B CA    1 ? 
ATOM   5882  C  C     . ARG B 1 142 ? -14.156 -4.606  -90.209  1    40.311  ? 142  ARG B C     1 ? 
ATOM   5883  O  O     . ARG B 1 142 ? -13.16  -5.257  -90.537  1    39.958  ? 142  ARG B O     1 ? 
ATOM   5884  C  CB    . ARG B 1 142 ? -14.743 -2.623  -91.537  1    42.78   ? 142  ARG B CB    1 ? 
ATOM   5885  C  CG    . ARG B 1 142 ? -15.547 -1.838  -92.562  1    48.427  ? 142  ARG B CG    1 ? 
ATOM   5886  C  CD    . ARG B 1 142 ? -14.902 -0.503  -92.935  1    60.476  ? 142  ARG B CD    1 ? 
ATOM   5887  N  NE    . ARG B 1 142 ? -14.795 0.567   -91.928  1    66.133  ? 142  ARG B NE    1 ? 
ATOM   5888  C  CZ    . ARG B 1 142 ? -15.738 1.405   -91.472  1    60.145  ? 142  ARG B CZ    1 ? 
ATOM   5889  N  NH1   . ARG B 1 142 ? -17.006 1.313   -91.847  1    52.584  ? 142  ARG B NH1   1 ? 
ATOM   5890  N  NH2   . ARG B 1 142 ? -15.395 2.354   -90.626  1    57.252  ? 142  ARG B NH2   1 ? 
ATOM   5891  N  N     . LEU B 1 143 ? -14.394 -4.239  -88.939  1    33.395  ? 143  LEU B N     1 ? 
ATOM   5892  C  CA    . LEU B 1 143 ? -13.621 -4.822  -87.858  1    33.22   ? 143  LEU B CA    1 ? 
ATOM   5893  C  C     . LEU B 1 143 ? -13.677 -6.361  -87.891  1    30.348  ? 143  LEU B C     1 ? 
ATOM   5894  O  O     . LEU B 1 143 ? -12.675 -7.021  -87.625  1    30.418  ? 143  LEU B O     1 ? 
ATOM   5895  C  CB    . LEU B 1 143 ? -14.091 -4.305  -86.504  1    32.173  ? 143  LEU B CB    1 ? 
ATOM   5896  C  CG    . LEU B 1 143 ? -13.349 -4.93   -85.321  1    32.555  ? 143  LEU B CG    1 ? 
ATOM   5897  C  CD1   . LEU B 1 143 ? -11.843 -4.673  -85.42   1    33.072  ? 143  LEU B CD1   1 ? 
ATOM   5898  C  CD2   . LEU B 1 143 ? -13.913 -4.444  -83.997  1    41.165  ? 143  LEU B CD2   1 ? 
ATOM   5899  N  N     . HIS B 1 144 ? -14.86  -6.916  -88.17   1    33.162  ? 144  HIS B N     1 ? 
ATOM   5900  C  CA    . HIS B 1 144 ? -15.07  -8.349  -88.04   1    35.664  ? 144  HIS B CA    1 ? 
ATOM   5901  C  C     . HIS B 1 144 ? -14.173 -9.068  -89.048  1    36.047  ? 144  HIS B C     1 ? 
ATOM   5902  O  O     . HIS B 1 144 ? -13.578 -10.104 -88.749  1    37.986  ? 144  HIS B O     1 ? 
ATOM   5903  C  CB    . HIS B 1 144 ? -16.562 -8.666  -88.165  1    34.264  ? 144  HIS B CB    1 ? 
ATOM   5904  C  CG    . HIS B 1 144 ? -16.862 -10.123 -88.27   1    42.269  ? 144  HIS B CG    1 ? 
ATOM   5905  N  ND1   . HIS B 1 144 ? -16.974 -10.947 -87.169  1    40.923  ? 144  HIS B ND1   1 ? 
ATOM   5906  C  CD2   . HIS B 1 144 ? -17.06  -10.906 -89.346  1    39.725  ? 144  HIS B CD2   1 ? 
ATOM   5907  C  CE1   . HIS B 1 144 ? -17.251 -12.187 -87.571  1    41.393  ? 144  HIS B CE1   1 ? 
ATOM   5908  N  NE2   . HIS B 1 144 ? -17.302 -12.185 -88.89   1    40.399  ? 144  HIS B NE2   1 ? 
ATOM   5909  N  N     . GLU B 1 145 ? -14.094 -8.475  -90.242  1    38.212  ? 145  GLU B N     1 ? 
ATOM   5910  C  CA    . GLU B 1 145 ? -13.307 -8.983  -91.354  1    38.301  ? 145  GLU B CA    1 ? 
ATOM   5911  C  C     . GLU B 1 145 ? -11.822 -8.875  -91.012  1    38.64   ? 145  GLU B C     1 ? 
ATOM   5912  O  O     . GLU B 1 145 ? -11.03  -9.76   -91.34   1    39.56   ? 145  GLU B O     1 ? 
ATOM   5913  C  CB    . GLU B 1 145 ? -13.619 -8.145  -92.601  1    41.356  ? 145  GLU B CB    1 ? 
ATOM   5914  C  CG    . GLU B 1 145 ? -14.977 -8.422  -93.237  1    46.308  ? 145  GLU B CG    1 ? 
ATOM   5915  C  CD    . GLU B 1 145 ? -15.12  -9.87   -93.685  1    62.838  ? 145  GLU B CD    1 ? 
ATOM   5916  O  OE1   . GLU B 1 145 ? -14.264 -10.289 -94.499  1    65.969  ? 145  GLU B OE1   1 ? 
ATOM   5917  O  OE2   . GLU B 1 145 ? -16.055 -10.586 -93.228  1    65.059  ? 145  GLU B OE2   1 ? 
ATOM   5918  N  N     . HIS B 1 146 ? -11.44  -7.779  -90.356  1    33.519  ? 146  HIS B N     1 ? 
ATOM   5919  C  CA    . HIS B 1 146 ? -10.05  -7.632  -89.956  1    37.007  ? 146  HIS B CA    1 ? 
ATOM   5920  C  C     . HIS B 1 146 ? -9.664  -8.672  -88.894  1    34.294  ? 146  HIS B C     1 ? 
ATOM   5921  O  O     . HIS B 1 146 ? -8.525  -9.127  -88.86   1    34.473  ? 146  HIS B O     1 ? 
ATOM   5922  C  CB    . HIS B 1 146 ? -9.74   -6.177  -89.576  1    34.05   ? 146  HIS B CB    1 ? 
ATOM   5923  C  CG    . HIS B 1 146 ? -9.668  -5.282  -90.771  1    35.044  ? 146  HIS B CG    1 ? 
ATOM   5924  N  ND1   . HIS B 1 146 ? -10.776 -4.906  -91.512  1    37.263  ? 146  HIS B ND1   1 ? 
ATOM   5925  C  CD2   . HIS B 1 146 ? -8.595  -4.764  -91.391  1    33.609  ? 146  HIS B CD2   1 ? 
ATOM   5926  C  CE1   . HIS B 1 146 ? -10.377 -4.142  -92.529  1    42.377  ? 146  HIS B CE1   1 ? 
ATOM   5927  N  NE2   . HIS B 1 146 ? -9.052  -4.063  -92.483  1    41.134  ? 146  HIS B NE2   1 ? 
ATOM   5928  N  N     . LEU B 1 147 ? -10.59  -9.021  -87.997  1    34.374  ? 147  LEU B N     1 ? 
ATOM   5929  C  CA    . LEU B 1 147 ? -10.222 -9.921  -86.908  1    39.22   ? 147  LEU B CA    1 ? 
ATOM   5930  C  C     . LEU B 1 147 ? -10.032 -11.332 -87.468  1    36.046  ? 147  LEU B C     1 ? 
ATOM   5931  O  O     . LEU B 1 147 ? -9.063  -12.019 -87.126  1    36.936  ? 147  LEU B O     1 ? 
ATOM   5932  C  CB    . LEU B 1 147 ? -11.227 -9.861  -85.75   1    35.236  ? 147  LEU B CB    1 ? 
ATOM   5933  C  CG    . LEU B 1 147 ? -11.206 -8.586  -84.894  1    34.33   ? 147  LEU B CG    1 ? 
ATOM   5934  C  CD1   . LEU B 1 147 ? -12.398 -8.527  -83.94   1    33.821  ? 147  LEU B CD1   1 ? 
ATOM   5935  C  CD2   . LEU B 1 147 ? -9.895  -8.412  -84.117  1    34.823  ? 147  LEU B CD2   1 ? 
ATOM   5936  N  N     . LYS B 1 148 ? -10.942 -11.727 -88.369  1    35.153  ? 148  LYS B N     1 ? 
ATOM   5937  C  CA    . LYS B 1 148 ? -10.878 -13.031 -89.015  1    38.692  ? 148  LYS B CA    1 ? 
ATOM   5938  C  C     . LYS B 1 148 ? -9.542  -13.155 -89.735  1    37.194  ? 148  LYS B C     1 ? 
ATOM   5939  O  O     . LYS B 1 148 ? -8.81   -14.116 -89.532  1    37.039  ? 148  LYS B O     1 ? 
ATOM   5940  C  CB    . LYS B 1 148 ? -12.008 -13.253 -90.021  1    35.185  ? 148  LYS B CB    1 ? 
ATOM   5941  C  CG    . LYS B 1 148 ? -13.329 -13.611 -89.374  1    45.624  ? 148  LYS B CG    1 ? 
ATOM   5942  C  CD    . LYS B 1 148 ? -14.361 -14.182 -90.339  1    50.885  ? 148  LYS B CD    1 ? 
ATOM   5943  C  CE    . LYS B 1 148 ? -14.575 -13.276 -91.521  1    61.169  ? 148  LYS B CE    1 ? 
ATOM   5944  N  NZ    . LYS B 1 148 ? -15.694 -13.713 -92.362  1    71.81   ? 148  LYS B NZ    1 ? 
ATOM   5945  N  N     . TYR B 1 149 ? -9.236  -12.134 -90.539  1    39.852  ? 149  TYR B N     1 ? 
ATOM   5946  C  CA    . TYR B 1 149 ? -7.996  -12.067 -91.283  1    40.003  ? 149  TYR B CA    1 ? 
ATOM   5947  C  C     . TYR B 1 149 ? -6.845  -12.216 -90.29   1    42.512  ? 149  TYR B C     1 ? 
ATOM   5948  O  O     . TYR B 1 149 ? -5.941  -13.029 -90.488  1    47.109  ? 149  TYR B O     1 ? 
ATOM   5949  C  CB    . TYR B 1 149 ? -7.979  -10.753 -92.078  1    39.195  ? 149  TYR B CB    1 ? 
ATOM   5950  C  CG    . TYR B 1 149 ? -6.569  -10.3   -92.443  1    38.259  ? 149  TYR B CG    1 ? 
ATOM   5951  C  CD1   . TYR B 1 149 ? -5.792  -9.559  -91.55   1    43.992  ? 149  TYR B CD1   1 ? 
ATOM   5952  C  CD2   . TYR B 1 149 ? -5.994  -10.635 -93.661  1    38.897  ? 149  TYR B CD2   1 ? 
ATOM   5953  C  CE1   . TYR B 1 149 ? -4.487  -9.175  -91.845  1    42.783  ? 149  TYR B CE1   1 ? 
ATOM   5954  C  CE2   . TYR B 1 149 ? -4.701  -10.238 -93.976  1    41.043  ? 149  TYR B CE2   1 ? 
ATOM   5955  C  CZ    . TYR B 1 149 ? -3.935  -9.519  -93.071  1    44.275  ? 149  TYR B CZ    1 ? 
ATOM   5956  O  OH    . TYR B 1 149 ? -2.656  -9.122  -93.384  1    44.263  ? 149  TYR B OH    1 ? 
ATOM   5957  N  N     . PHE B 1 150 ? -6.905  -11.446 -89.198  1    41.636  ? 150  PHE B N     1 ? 
ATOM   5958  C  CA    . PHE B 1 150 ? -5.817  -11.435 -88.233  1    39.963  ? 150  PHE B CA    1 ? 
ATOM   5959  C  C     . PHE B 1 150 ? -5.554  -12.854 -87.719  1    37.543  ? 150  PHE B C     1 ? 
ATOM   5960  O  O     . PHE B 1 150 ? -4.396  -13.271 -87.594  1    33.964  ? 150  PHE B O     1 ? 
ATOM   5961  C  CB    . PHE B 1 150 ? -5.996  -10.42  -87.09   1    45.353  ? 150  PHE B CB    1 ? 
ATOM   5962  C  CG    . PHE B 1 150 ? -4.929  -10.536 -86.001  1    43.185  ? 150  PHE B CG    1 ? 
ATOM   5963  C  CD1   . PHE B 1 150 ? -3.709  -9.879  -86.12   1    47.388  ? 150  PHE B CD1   1 ? 
ATOM   5964  C  CD2   . PHE B 1 150 ? -5.13   -11.351 -84.893  1    47.274  ? 150  PHE B CD2   1 ? 
ATOM   5965  C  CE1   . PHE B 1 150 ? -2.731  -10.005 -85.143  1    52.449  ? 150  PHE B CE1   1 ? 
ATOM   5966  C  CE2   . PHE B 1 150 ? -4.159  -11.466 -83.908  1    52.853  ? 150  PHE B CE2   1 ? 
ATOM   5967  C  CZ    . PHE B 1 150 ? -2.964  -10.791 -84.036  1    54.612  ? 150  PHE B CZ    1 ? 
ATOM   5968  N  N     . VAL B 1 151 ? -6.636  -13.582 -87.418  1    32.706  ? 151  VAL B N     1 ? 
ATOM   5969  C  CA    . VAL B 1 151 ? -6.492  -14.927 -86.877  1    37.98   ? 151  VAL B CA    1 ? 
ATOM   5970  C  C     . VAL B 1 151 ? -5.826  -15.836 -87.916  1    36.196  ? 151  VAL B C     1 ? 
ATOM   5971  O  O     . VAL B 1 151 ? -4.863  -16.536 -87.616  1    38.266  ? 151  VAL B O     1 ? 
ATOM   5972  C  CB    . VAL B 1 151 ? -7.87   -15.458 -86.437  1    40.442  ? 151  VAL B CB    1 ? 
ATOM   5973  C  CG1   . VAL B 1 151 ? -7.881  -16.975 -86.257  1    38.038  ? 151  VAL B CG1   1 ? 
ATOM   5974  C  CG2   . VAL B 1 151 ? -8.349  -14.742 -85.169  1    37.748  ? 151  VAL B CG2   1 ? 
ATOM   5975  N  N     . ASN B 1 152 ? -6.349  -15.803 -89.141  1    36.589  ? 152  ASN B N     1 ? 
ATOM   5976  C  CA    . ASN B 1 152 ? -5.8    -16.561 -90.257  1    40.376  ? 152  ASN B CA    1 ? 
ATOM   5977  C  C     . ASN B 1 152 ? -4.329  -16.222 -90.457  1    39.639  ? 152  ASN B C     1 ? 
ATOM   5978  O  O     . ASN B 1 152 ? -3.529  -17.141 -90.632  1    38.898  ? 152  ASN B O     1 ? 
ATOM   5979  C  CB    . ASN B 1 152 ? -6.63   -16.401 -91.523  1    38.225  ? 152  ASN B CB    1 ? 
ATOM   5980  C  CG    . ASN B 1 152 ? -7.911  -17.185 -91.424  1    41.721  ? 152  ASN B CG    1 ? 
ATOM   5981  O  OD1   . ASN B 1 152 ? -7.901  -18.393 -91.666  1    46.454  ? 152  ASN B OD1   1 ? 
ATOM   5982  N  ND2   . ASN B 1 152 ? -9.013  -16.544 -91.059  1    44.003  ? 152  ASN B ND2   1 ? 
ATOM   5983  N  N     . MET B 1 153 ? -3.97   -14.927 -90.358  1    34.727  ? 153  MET B N     1 ? 
ATOM   5984  C  CA    . MET B 1 153 ? -2.592  -14.505 -90.594  1    36.16   ? 153  MET B CA    1 ? 
ATOM   5985  C  C     . MET B 1 153 ? -1.656  -15.111 -89.553  1    38.963  ? 153  MET B C     1 ? 
ATOM   5986  O  O     . MET B 1 153 ? -0.602  -15.647 -89.903  1    39.559  ? 153  MET B O     1 ? 
ATOM   5987  C  CB    . MET B 1 153 ? -2.425  -12.977 -90.603  1    41.929  ? 153  MET B CB    1 ? 
ATOM   5988  C  CG    . MET B 1 153 ? -0.988  -12.493 -90.832  1    50.667  ? 153  MET B CG    1 ? 
ATOM   5989  S  SD    . MET B 1 153 ? 0.118   -12.212 -89.425  1    58.627  ? 153  MET B SD    1 ? 
ATOM   5990  C  CE    . MET B 1 153 ? -0.534  -10.643 -88.825  1    68.598  ? 153  MET B CE    1 ? 
ATOM   5991  N  N     . LYS B 1 154 ? -2.036  -14.974 -88.266  1    39.695  ? 154  LYS B N     1 ? 
ATOM   5992  C  CA    . LYS B 1 154 ? -1.235  -15.43  -87.137  1    38.191  ? 154  LYS B CA    1 ? 
ATOM   5993  C  C     . LYS B 1 154 ? -1.063  -16.955 -87.196  1    40.288  ? 154  LYS B C     1 ? 
ATOM   5994  O  O     . LYS B 1 154 ? 0.05    -17.492 -87.064  1    36.389  ? 154  LYS B O     1 ? 
ATOM   5995  C  CB    . LYS B 1 154 ? -1.761  -14.807 -85.823  1    38.729  ? 154  LYS B CB    1 ? 
ATOM   5996  C  CG    . LYS B 1 154 ? -1.108  -13.464 -85.449  1    39.008  ? 154  LYS B CG    1 ? 
ATOM   5997  C  CD    . LYS B 1 154 ? 0.271   -13.788 -84.879  1    43.408  ? 154  LYS B CD    1 ? 
ATOM   5998  C  CE    . LYS B 1 154 ? 1.384   -12.879 -85.223  1    47.436  ? 154  LYS B CE    1 ? 
ATOM   5999  N  NZ    . LYS B 1 154 ? 1.758   -13.058 -86.632  1    59.74   ? 154  LYS B NZ    1 ? 
ATOM   6000  N  N     . ILE B 1 155 ? -2.183  -17.649 -87.411  1    35.682  ? 155  ILE B N     1 ? 
ATOM   6001  C  CA    . ILE B 1 155 ? -2.153  -19.097 -87.564  1    40.042  ? 155  ILE B CA    1 ? 
ATOM   6002  C  C     . ILE B 1 155 ? -1.159  -19.478 -88.659  1    45.158  ? 155  ILE B C     1 ? 
ATOM   6003  O  O     . ILE B 1 155 ? -0.401  -20.437 -88.495  1    40.526  ? 155  ILE B O     1 ? 
ATOM   6004  C  CB    . ILE B 1 155 ? -3.564  -19.66  -87.809  1    41.519  ? 155  ILE B CB    1 ? 
ATOM   6005  C  CG1   . ILE B 1 155 ? -4.362  -19.702 -86.489  1    34.967  ? 155  ILE B CG1   1 ? 
ATOM   6006  C  CG2   . ILE B 1 155 ? -3.502  -21.033 -88.493  1    41.699  ? 155  ILE B CG2   1 ? 
ATOM   6007  C  CD1   . ILE B 1 155 ? -5.861  -19.914 -86.656  1    31.925  ? 155  ILE B CD1   1 ? 
ATOM   6008  N  N     . SER B 1 156 ? -1.136  -18.689 -89.741  1    47.184  ? 156  SER B N     1 ? 
ATOM   6009  C  CA    . SER B 1 156 ? -0.375  -19.072 -90.92   1    42.381  ? 156  SER B CA    1 ? 
ATOM   6010  C  C     . SER B 1 156 ? 1.083   -18.627 -90.85   1    44.706  ? 156  SER B C     1 ? 
ATOM   6011  O  O     . SER B 1 156 ? 1.841   -19.019 -91.733  1    45.839  ? 156  SER B O     1 ? 
ATOM   6012  C  CB    . SER B 1 156 ? -1.018  -18.599 -92.213  1    39.422  ? 156  SER B CB    1 ? 
ATOM   6013  O  OG    . SER B 1 156 ? -2.355  -19.068 -92.369  1    42.372  ? 156  SER B OG    1 ? 
ATOM   6014  N  N     . THR B 1 157 ? 1.481   -17.817 -89.855  1    46.368  ? 157  THR B N     1 ? 
ATOM   6015  C  CA    . THR B 1 157 ? 2.799   -17.176 -89.918  1    50.809  ? 157  THR B CA    1 ? 
ATOM   6016  C  C     . THR B 1 157 ? 3.579   -17.34  -88.616  1    54.002  ? 157  THR B C     1 ? 
ATOM   6017  O  O     . THR B 1 157 ? 4.804   -17.217 -88.624  1    52.905  ? 157  THR B O     1 ? 
ATOM   6018  C  CB    . THR B 1 157 ? 2.755   -15.678 -90.26   1    51.595  ? 157  THR B CB    1 ? 
ATOM   6019  O  OG1   . THR B 1 157 ? 1.904   -15.053 -89.299  1    48.576  ? 157  THR B OG1   1 ? 
ATOM   6020  C  CG2   . THR B 1 157 ? 2.361   -15.366 -91.694  1    45.589  ? 157  THR B CG2   1 ? 
ATOM   6021  N  N     . ASP B 1 158 ? 2.876   -17.527 -87.493  1    53.703  ? 158  ASP B N     1 ? 
ATOM   6022  C  CA    . ASP B 1 158 ? 3.532   -17.496 -86.191  1    49.194  ? 158  ASP B CA    1 ? 
ATOM   6023  C  C     . ASP B 1 158 ? 3.392   -18.876 -85.554  1    49.234  ? 158  ASP B C     1 ? 
ATOM   6024  O  O     . ASP B 1 158 ? 2.279   -19.288 -85.219  1    48.916  ? 158  ASP B O     1 ? 
ATOM   6025  C  CB    . ASP B 1 158 ? 2.987   -16.346 -85.345  1    47.95   ? 158  ASP B CB    1 ? 
ATOM   6026  C  CG    . ASP B 1 158 ? 3.729   -15.981 -84.061  1    61.914  ? 158  ASP B CG    1 ? 
ATOM   6027  O  OD1   . ASP B 1 158 ? 4.291   -16.899 -83.416  1    65.188  ? 158  ASP B OD1   1 ? 
ATOM   6028  O  OD2   . ASP B 1 158 ? 3.698   -14.781 -83.68   1    57.426  ? 158  ASP B OD2   1 ? 
ATOM   6029  N  N     . LYS B 1 159 ? 4.531   -19.564 -85.37   1    46.382  ? 159  LYS B N     1 ? 
ATOM   6030  C  CA    . LYS B 1 159 ? 4.578   -20.89  -84.763  1    49.178  ? 159  LYS B CA    1 ? 
ATOM   6031  C  C     . LYS B 1 159 ? 3.898   -20.921 -83.393  1    50.728  ? 159  LYS B C     1 ? 
ATOM   6032  O  O     . LYS B 1 159 ? 3.259   -21.922 -83.054  1    45.46   ? 159  LYS B O     1 ? 
ATOM   6033  C  CB    . LYS B 1 159 ? 5.981   -21.511 -84.745  1    57.676  ? 159  LYS B CB    1 ? 
ATOM   6034  C  CG    . LYS B 1 159 ? 6.415   -21.997 -86.124  1    60.384  ? 159  LYS B CG    1 ? 
ATOM   6035  C  CD    . LYS B 1 159 ? 7.865   -22.443 -86.256  1    69.955  ? 159  LYS B CD    1 ? 
ATOM   6036  C  CE    . LYS B 1 159 ? 8.181   -22.664 -87.704  1    76.163  ? 159  LYS B CE    1 ? 
ATOM   6037  N  NZ    . LYS B 1 159 ? 9.617   -22.531 -87.963  1    81.487  ? 159  LYS B NZ    1 ? 
ATOM   6038  N  N     . SER B 1 160 ? 4.006   -19.829 -82.618  1    42.518  ? 160  SER B N     1 ? 
ATOM   6039  C  CA    . SER B 1 160 ? 3.401   -19.826 -81.293  1    45.701  ? 160  SER B CA    1 ? 
ATOM   6040  C  C     . SER B 1 160 ? 1.873   -19.861 -81.378  1    41.835  ? 160  SER B C     1 ? 
ATOM   6041  O  O     . SER B 1 160 ? 1.222   -20.198 -80.399  1    40.857  ? 160  SER B O     1 ? 
ATOM   6042  C  CB    . SER B 1 160 ? 3.93    -18.719 -80.394  1    52.527  ? 160  SER B CB    1 ? 
ATOM   6043  O  OG    . SER B 1 160 ? 3.528   -17.435 -80.851  1    64.33   ? 160  SER B OG    1 ? 
ATOM   6044  N  N     . TRP B 1 161 ? 1.306   -19.576 -82.567  1    43.669  ? 161  TRP B N     1 ? 
ATOM   6045  C  CA    . TRP B 1 161 ? -0.135  -19.709 -82.78   1    46.05   ? 161  TRP B CA    1 ? 
ATOM   6046  C  C     . TRP B 1 161 ? -0.546  -21.044 -83.422  1    45.643  ? 161  TRP B C     1 ? 
ATOM   6047  O  O     . TRP B 1 161 ? -1.703  -21.224 -83.813  1    37.809  ? 161  TRP B O     1 ? 
ATOM   6048  C  CB    . TRP B 1 161 ? -0.612  -18.548 -83.656  1    46.055  ? 161  TRP B CB    1 ? 
ATOM   6049  C  CG    . TRP B 1 161 ? -0.657  -17.225 -82.941  1    44.378  ? 161  TRP B CG    1 ? 
ATOM   6050  C  CD1   . TRP B 1 161 ? 0.392   -16.491 -82.461  1    44.134  ? 161  TRP B CD1   1 ? 
ATOM   6051  C  CD2   . TRP B 1 161 ? -1.851  -16.462 -82.675  1    41.666  ? 161  TRP B CD2   1 ? 
ATOM   6052  N  NE1   . TRP B 1 161 ? -0.07   -15.331 -81.89   1    42.843  ? 161  TRP B NE1   1 ? 
ATOM   6053  C  CE2   . TRP B 1 161 ? -1.439  -15.278 -82.022  1    45.702  ? 161  TRP B CE2   1 ? 
ATOM   6054  C  CE3   . TRP B 1 161 ? -3.212  -16.657 -82.935  1    45.757  ? 161  TRP B CE3   1 ? 
ATOM   6055  C  CZ2   . TRP B 1 161 ? -2.356  -14.306 -81.62   1    41.196  ? 161  TRP B CZ2   1 ? 
ATOM   6056  C  CZ3   . TRP B 1 161 ? -4.115  -15.682 -82.556  1    50.211  ? 161  TRP B CZ3   1 ? 
ATOM   6057  C  CH2   . TRP B 1 161 ? -3.69   -14.524 -81.899  1    46.943  ? 161  TRP B CH2   1 ? 
ATOM   6058  N  N     . GLN B 1 162 ? 0.385   -21.997 -83.524  1    43.416  ? 162  GLN B N     1 ? 
ATOM   6059  C  CA    . GLN B 1 162 ? 0.151   -23.133 -84.403  1    46.918  ? 162  GLN B CA    1 ? 
ATOM   6060  C  C     . GLN B 1 162 ? -0.235  -24.4   -83.641  1    52.41   ? 162  GLN B C     1 ? 
ATOM   6061  O  O     . GLN B 1 162 ? -0.785  -25.315 -84.248  1    57.785  ? 162  GLN B O     1 ? 
ATOM   6062  C  CB    . GLN B 1 162 ? 1.278   -23.309 -85.421  1    46.789  ? 162  GLN B CB    1 ? 
ATOM   6063  C  CG    . GLN B 1 162 ? 1.194   -22.321 -86.581  1    47.794  ? 162  GLN B CG    1 ? 
ATOM   6064  C  CD    . GLN B 1 162 ? 2.397   -22.347 -87.5    1    48.02   ? 162  GLN B CD    1 ? 
ATOM   6065  O  OE1   . GLN B 1 162 ? 3.33    -23.143 -87.322  1    41.906  ? 162  GLN B OE1   1 ? 
ATOM   6066  N  NE2   . GLN B 1 162 ? 2.387   -21.464 -88.495  1    47.65   ? 162  GLN B NE2   1 ? 
ATOM   6067  N  N     . GLY B 1 163 ? 0.022   -24.464 -82.329  1    45.697  ? 163  GLY B N     1 ? 
ATOM   6068  C  CA    . GLY B 1 163 ? -0.365  -25.664 -81.597  1    51.31   ? 163  GLY B CA    1 ? 
ATOM   6069  C  C     . GLY B 1 163 ? -1.623  -25.484 -80.746  1    53.794  ? 163  GLY B C     1 ? 
ATOM   6070  O  O     . GLY B 1 163 ? -1.848  -26.244 -79.815  1    60.193  ? 163  GLY B O     1 ? 
ATOM   6071  N  N     . VAL B 1 164 ? -2.454  -24.489 -81.066  1    50.68   ? 164  VAL B N     1 ? 
ATOM   6072  C  CA    . VAL B 1 164 ? -3.534  -24.104 -80.169  1    47.984  ? 164  VAL B CA    1 ? 
ATOM   6073  C  C     . VAL B 1 164 ? -4.84   -24.078 -80.96   1    43.804  ? 164  VAL B C     1 ? 
ATOM   6074  O  O     . VAL B 1 164 ? -4.832  -23.76  -82.149  1    42.701  ? 164  VAL B O     1 ? 
ATOM   6075  C  CB    . VAL B 1 164 ? -3.195  -22.71  -79.598  1    51.273  ? 164  VAL B CB    1 ? 
ATOM   6076  C  CG1   . VAL B 1 164 ? -4.292  -22.188 -78.686  1    52.639  ? 164  VAL B CG1   1 ? 
ATOM   6077  C  CG2   . VAL B 1 164 ? -1.853  -22.695 -78.871  1    49.494  ? 164  VAL B CG2   1 ? 
ATOM   6078  N  N     . THR B 1 165 ? -5.949  -24.437 -80.296  1    41.684  ? 165  THR B N     1 ? 
ATOM   6079  C  CA    . THR B 1 165 ? -7.28   -24.234 -80.845  1    37.029  ? 165  THR B CA    1 ? 
ATOM   6080  C  C     . THR B 1 165 ? -7.714  -22.792 -80.591  1    42.752  ? 165  THR B C     1 ? 
ATOM   6081  O  O     . THR B 1 165 ? -7.738  -22.325 -79.444  1    42.325  ? 165  THR B O     1 ? 
ATOM   6082  C  CB    . THR B 1 165 ? -8.273  -25.218 -80.239  1    40.203  ? 165  THR B CB    1 ? 
ATOM   6083  O  OG1   . THR B 1 165 ? -7.742  -26.509 -80.52   1    43.916  ? 165  THR B OG1   1 ? 
ATOM   6084  C  CG2   . THR B 1 165 ? -9.669  -25.041 -80.808  1    37.139  ? 165  THR B CG2   1 ? 
ATOM   6085  N  N     . ILE B 1 166 ? -8.091  -22.102 -81.676  1    34.689  ? 166  ILE B N     1 ? 
ATOM   6086  C  CA    . ILE B 1 166 ? -8.478  -20.705 -81.585  1    34.558  ? 166  ILE B CA    1 ? 
ATOM   6087  C  C     . ILE B 1 166 ? -9.963  -20.572 -81.884  1    36.831  ? 166  ILE B C     1 ? 
ATOM   6088  O  O     . ILE B 1 166 ? -10.437 -21.044 -82.912  1    44.892  ? 166  ILE B O     1 ? 
ATOM   6089  C  CB    . ILE B 1 166 ? -7.603  -19.854 -82.517  1    35.239  ? 166  ILE B CB    1 ? 
ATOM   6090  C  CG1   . ILE B 1 166 ? -6.156  -19.927 -82.049  1    39.449  ? 166  ILE B CG1   1 ? 
ATOM   6091  C  CG2   . ILE B 1 166 ? -8.093  -18.403 -82.552  1    35.827  ? 166  ILE B CG2   1 ? 
ATOM   6092  C  CD1   . ILE B 1 166 ? -5.117  -19.674 -83.12   1    42.401  ? 166  ILE B CD1   1 ? 
ATOM   6093  N  N     . TYR B 1 167 ? -10.702 -19.952 -80.969  1    30.787  ? 167  TYR B N     1 ? 
ATOM   6094  C  CA    . TYR B 1 167 ? -12.1   -19.692 -81.253  1    31.668  ? 167  TYR B CA    1 ? 
ATOM   6095  C  C     . TYR B 1 167 ? -12.267 -18.188 -81.438  1    33.538  ? 167  TYR B C     1 ? 
ATOM   6096  O  O     . TYR B 1 167 ? -11.714 -17.416 -80.664  1    35.035  ? 167  TYR B O     1 ? 
ATOM   6097  C  CB    . TYR B 1 167 ? -13.051 -20.121 -80.137  1    29.106  ? 167  TYR B CB    1 ? 
ATOM   6098  C  CG    . TYR B 1 167 ? -13.08  -21.618 -79.843  1    35.183  ? 167  TYR B CG    1 ? 
ATOM   6099  C  CD1   . TYR B 1 167 ? -12.057 -22.233 -79.139  1    32.542  ? 167  TYR B CD1   1 ? 
ATOM   6100  C  CD2   . TYR B 1 167 ? -14.15  -22.407 -80.264  1    33.978  ? 167  TYR B CD2   1 ? 
ATOM   6101  C  CE1   . TYR B 1 167 ? -12.1   -23.592 -78.845  1    36.246  ? 167  TYR B CE1   1 ? 
ATOM   6102  C  CE2   . TYR B 1 167 ? -14.221 -23.75  -79.95   1    34.397  ? 167  TYR B CE2   1 ? 
ATOM   6103  C  CZ    . TYR B 1 167 ? -13.182 -24.352 -79.266  1    34.552  ? 167  TYR B CZ    1 ? 
ATOM   6104  O  OH    . TYR B 1 167 ? -13.278 -25.688 -79.01   1    39.871  ? 167  TYR B OH    1 ? 
ATOM   6105  N  N     . PHE B 1 168 ? -13.067 -17.8   -82.434  1    32.262  ? 168  PHE B N     1 ? 
ATOM   6106  C  CA    . PHE B 1 168 ? -13.47  -16.419 -82.618  1    29.694  ? 168  PHE B CA    1 ? 
ATOM   6107  C  C     . PHE B 1 168 ? -14.991 -16.347 -82.649  1    31.117  ? 168  PHE B C     1 ? 
ATOM   6108  O  O     . PHE B 1 168 ? -15.633 -16.802 -83.616  1    33.524  ? 168  PHE B O     1 ? 
ATOM   6109  C  CB    . PHE B 1 168 ? -12.832 -15.875 -83.906  1    36.786  ? 168  PHE B CB    1 ? 
ATOM   6110  C  CG    . PHE B 1 168 ? -13.24  -14.43  -84.194  1    44.512  ? 168  PHE B CG    1 ? 
ATOM   6111  C  CD1   . PHE B 1 168 ? -13.147 -13.443 -83.21   1    48.475  ? 168  PHE B CD1   1 ? 
ATOM   6112  C  CD2   . PHE B 1 168 ? -13.725 -14.057 -85.436  1    45.518  ? 168  PHE B CD2   1 ? 
ATOM   6113  C  CE1   . PHE B 1 168 ? -13.524 -12.135 -83.471  1    46.637  ? 168  PHE B CE1   1 ? 
ATOM   6114  C  CE2   . PHE B 1 168 ? -14.105 -12.747 -85.693  1    44.686  ? 168  PHE B CE2   1 ? 
ATOM   6115  C  CZ    . PHE B 1 168 ? -13.999 -11.79  -84.715  1    46.483  ? 168  PHE B CZ    1 ? 
ATOM   6116  N  N     . SER B 1 169 ? -15.579 -15.761 -81.599  1    29.668  ? 169  SER B N     1 ? 
ATOM   6117  C  CA    . SER B 1 169 ? -17.014 -15.495 -81.639  1    29.526  ? 169  SER B CA    1 ? 
ATOM   6118  C  C     . SER B 1 169 ? -17.246 -13.999 -81.883  1    34.13   ? 169  SER B C     1 ? 
ATOM   6119  O  O     . SER B 1 169 ? -17.094 -13.181 -80.968  1    31.362  ? 169  SER B O     1 ? 
ATOM   6120  C  CB    . SER B 1 169 ? -17.666 -15.978 -80.39   1    29.42   ? 169  SER B CB    1 ? 
ATOM   6121  O  OG    . SER B 1 169 ? -19.08  -15.874 -80.466  1    33.684  ? 169  SER B OG    1 ? 
ATOM   6122  N  N     . GLY B 1 170 ? -17.599 -13.625 -83.125  1    32.839  ? 170  GLY B N     1 ? 
ATOM   6123  C  CA    . GLY B 1 170 ? -17.667 -12.209 -83.492  1    27.746  ? 170  GLY B CA    1 ? 
ATOM   6124  C  C     . GLY B 1 170 ? -19.048 -11.584 -83.299  1    29.252  ? 170  GLY B C     1 ? 
ATOM   6125  O  O     . GLY B 1 170 ? -19.932 -12.199 -82.71   1    23.752  ? 170  GLY B O     1 ? 
ATOM   6126  N  N     . HIS B 1 171 ? -19.243 -10.358 -83.848  1    28.486  ? 171  HIS B N     1 ? 
ATOM   6127  C  CA    . HIS B 1 171 ? -20.411 -9.545  -83.515  1    30.073  ? 171  HIS B CA    1 ? 
ATOM   6128  C  C     . HIS B 1 171 ? -21.696 -10.113 -84.139  1    32.346  ? 171  HIS B C     1 ? 
ATOM   6129  O  O     . HIS B 1 171 ? -22.817 -9.692  -83.819  1    29.539  ? 171  HIS B O     1 ? 
ATOM   6130  C  CB    . HIS B 1 171 ? -20.179 -8.067  -83.877  1    29.841  ? 171  HIS B CB    1 ? 
ATOM   6131  C  CG    . HIS B 1 171 ? -20.249 -7.842  -85.363  1    34.822  ? 171  HIS B CG    1 ? 
ATOM   6132  N  ND1   . HIS B 1 171 ? -21.207 -7.056  -85.975  1    35.639  ? 171  HIS B ND1   1 ? 
ATOM   6133  C  CD2   . HIS B 1 171 ? -19.573 -8.435  -86.361  1    35.982  ? 171  HIS B CD2   1 ? 
ATOM   6134  C  CE1   . HIS B 1 171 ? -21.059 -7.132  -87.291  1    34.878  ? 171  HIS B CE1   1 ? 
ATOM   6135  N  NE2   . HIS B 1 171 ? -20.07  -7.96   -87.549  1    37.844  ? 171  HIS B NE2   1 ? 
ATOM   6136  N  N     . GLU B 1 172 ? -21.557 -11.108 -85.016  1    35.769  ? 172  GLU B N     1 ? 
ATOM   6137  C  CA    . GLU B 1 172 ? -22.765 -11.664 -85.62   1    41.25   ? 172  GLU B CA    1 ? 
ATOM   6138  C  C     . GLU B 1 172 ? -23.327 -12.81  -84.777  1    39.946  ? 172  GLU B C     1 ? 
ATOM   6139  O  O     . GLU B 1 172 ? -24.444 -13.284 -85.025  1    35.123  ? 172  GLU B O     1 ? 
ATOM   6140  C  CB    . GLU B 1 172 ? -22.545 -12.08  -87.077  1    47.55   ? 172  GLU B CB    1 ? 
ATOM   6141  C  CG    . GLU B 1 172 ? -22.036 -10.948 -87.964  1    58.352  ? 172  GLU B CG    1 ? 
ATOM   6142  C  CD    . GLU B 1 172 ? -22.33  -11.218 -89.429  1    66.646  ? 172  GLU B CD    1 ? 
ATOM   6143  O  OE1   . GLU B 1 172 ? -21.691 -12.127 -89.991  1    60.157  ? 172  GLU B OE1   1 ? 
ATOM   6144  O  OE2   . GLU B 1 172 ? -23.206 -10.534 -89.998  1    72.422  ? 172  GLU B OE2   1 ? 
ATOM   6145  N  N     . THR B 1 173 ? -22.556 -13.226 -83.763  1    36.572  ? 173  THR B N     1 ? 
ATOM   6146  C  CA    . THR B 1 173 ? -22.982 -14.312 -82.886  1    31.589  ? 173  THR B CA    1 ? 
ATOM   6147  C  C     . THR B 1 173 ? -23.617 -13.729 -81.634  1    31.884  ? 173  THR B C     1 ? 
ATOM   6148  O  O     . THR B 1 173 ? -22.946 -13.104 -80.8    1    34.326  ? 173  THR B O     1 ? 
ATOM   6149  C  CB    . THR B 1 173 ? -21.791 -15.19  -82.527  1    29.504  ? 173  THR B CB    1 ? 
ATOM   6150  O  OG1   . THR B 1 173 ? -21.167 -15.465 -83.783  1    30.877  ? 173  THR B OG1   1 ? 
ATOM   6151  C  CG2   . THR B 1 173 ? -22.249 -16.479 -81.871  1    30.521  ? 173  THR B CG2   1 ? 
ATOM   6152  N  N     . PRO B 1 174 ? -24.934 -13.931 -81.479  1    30.893  ? 174  PRO B N     1 ? 
ATOM   6153  C  CA    . PRO B 1 174 ? -25.692 -13.27  -80.414  1    33.286  ? 174  PRO B CA    1 ? 
ATOM   6154  C  C     . PRO B 1 174 ? -25.057 -13.551 -79.043  1    37.371  ? 174  PRO B C     1 ? 
ATOM   6155  O  O     . PRO B 1 174 ? -24.431 -14.596 -78.833  1    35.758  ? 174  PRO B O     1 ? 
ATOM   6156  C  CB    . PRO B 1 174 ? -27.079 -13.896 -80.588  1    32.024  ? 174  PRO B CB    1 ? 
ATOM   6157  C  CG    . PRO B 1 174 ? -27.129 -14.21  -82.078  1    32.329  ? 174  PRO B CG    1 ? 
ATOM   6158  C  CD    . PRO B 1 174 ? -25.751 -14.798 -82.341  1    32.474  ? 174  PRO B CD    1 ? 
ATOM   6159  N  N     . GLY B 1 175 ? -25.132 -12.545 -78.162  1    33.159  ? 175  GLY B N     1 ? 
ATOM   6160  C  CA    . GLY B 1 175 ? -24.709 -12.632 -76.77   1    33.015  ? 175  GLY B CA    1 ? 
ATOM   6161  C  C     . GLY B 1 175 ? -23.523 -11.704 -76.495  1    30.471  ? 175  GLY B C     1 ? 
ATOM   6162  O  O     . GLY B 1 175 ? -22.654 -11.518 -77.351  1    28.737  ? 175  GLY B O     1 ? 
ATOM   6163  N  N     . GLU B 1 176 ? -23.504 -11.12  -75.294  1    30.714  ? 176  GLU B N     1 ? 
ATOM   6164  C  CA    . GLU B 1 176 ? -22.336 -10.386 -74.846  1    30.848  ? 176  GLU B CA    1 ? 
ATOM   6165  C  C     . GLU B 1 176 ? -21.168 -11.355 -74.743  1    28.992  ? 176  GLU B C     1 ? 
ATOM   6166  O  O     . GLU B 1 176 ? -21.385 -12.519 -74.456  1    29.759  ? 176  GLU B O     1 ? 
ATOM   6167  C  CB    . GLU B 1 176 ? -22.607 -9.705  -73.504  1    38.34   ? 176  GLU B CB    1 ? 
ATOM   6168  C  CG    . GLU B 1 176 ? -23.461 -8.449  -73.647  1    54.054  ? 176  GLU B CG    1 ? 
ATOM   6169  C  CD    . GLU B 1 176 ? -23.591 -7.683  -72.339  1    74.112  ? 176  GLU B CD    1 ? 
ATOM   6170  O  OE1   . GLU B 1 176 ? -23.176 -6.49   -72.318  1    67.278  ? 176  GLU B OE1   1 ? 
ATOM   6171  O  OE2   . GLU B 1 176 ? -24.107 -8.281  -71.353  1    78.596  ? 176  GLU B OE2   1 ? 
ATOM   6172  N  N     . GLY B 1 177 ? -19.951 -10.874 -75.019  1    30.949  ? 177  GLY B N     1 ? 
ATOM   6173  C  CA    . GLY B 1 177 ? -18.759 -11.712 -75.092  1    39.392  ? 177  GLY B CA    1 ? 
ATOM   6174  C  C     . GLY B 1 177 ? -18.541 -12.532 -73.817  1    44.617  ? 177  GLY B C     1 ? 
ATOM   6175  O  O     . GLY B 1 177 ? -18.11  -13.692 -73.88   1    41.743  ? 177  GLY B O     1 ? 
ATOM   6176  N  N     . GLU B 1 178 ? -18.859 -11.901 -72.676  1    40.229  ? 178  GLU B N     1 ? 
ATOM   6177  C  CA    . GLU B 1 178 ? -18.815 -12.505 -71.353  1    47.964  ? 178  GLU B CA    1 ? 
ATOM   6178  C  C     . GLU B 1 178 ? -19.734 -13.719 -71.335  1    40.783  ? 178  GLU B C     1 ? 
ATOM   6179  O  O     . GLU B 1 178 ? -19.291 -14.797 -70.965  1    39.537  ? 178  GLU B O     1 ? 
ATOM   6180  C  CB    . GLU B 1 178 ? -19.125 -11.542 -70.197  1    56.104  ? 178  GLU B CB    1 ? 
ATOM   6181  C  CG    . GLU B 1 178 ? -18.246 -10.291 -70.17   1    73.362  ? 178  GLU B CG    1 ? 
ATOM   6182  C  CD    . GLU B 1 178 ? -18.779 -8.995  -70.783  1    86.992  ? 178  GLU B CD    1 ? 
ATOM   6183  O  OE1   . GLU B 1 178 ? -19.44  -9.034  -71.852  1    72.185  ? 178  GLU B OE1   1 ? 
ATOM   6184  O  OE2   . GLU B 1 178 ? -18.499 -7.92   -70.192  1    84.574  ? 178  GLU B OE2   1 ? 
ATOM   6185  N  N     . HIS B 1 179 ? -20.994 -13.53  -71.735  1    35.938  ? 179  HIS B N     1 ? 
ATOM   6186  C  CA    . HIS B 1 179 ? -21.967 -14.607 -71.743  1    39.213  ? 179  HIS B CA    1 ? 
ATOM   6187  C  C     . HIS B 1 179 ? -21.527 -15.726 -72.699  1    39.501  ? 179  HIS B C     1 ? 
ATOM   6188  O  O     . HIS B 1 179 ? -21.758 -16.905 -72.433  1    36.324  ? 179  HIS B O     1 ? 
ATOM   6189  C  CB    . HIS B 1 179 ? -23.375 -14.088 -72.05   1    48.406  ? 179  HIS B CB    1 ? 
ATOM   6190  C  CG    . HIS B 1 179 ? -24.34  -15.182 -72.42   1    62.381  ? 179  HIS B CG    1 ? 
ATOM   6191  N  ND1   . HIS B 1 179 ? -24.509 -15.639 -73.714  1    62.284  ? 179  HIS B ND1   1 ? 
ATOM   6192  C  CD2   . HIS B 1 179 ? -25.187 -15.91  -71.667  1    73.914  ? 179  HIS B CD2   1 ? 
ATOM   6193  C  CE1   . HIS B 1 179 ? -25.421 -16.606 -73.727  1    68.413  ? 179  HIS B CE1   1 ? 
ATOM   6194  N  NE2   . HIS B 1 179 ? -25.851 -16.787 -72.495  1    65.998  ? 179  HIS B NE2   1 ? 
ATOM   6195  N  N     . LYS B 1 180 ? -20.86  -15.349 -73.795  1    37.083  ? 180  LYS B N     1 ? 
ATOM   6196  C  CA    . LYS B 1 180 ? -20.401 -16.311 -74.78   1    34.371  ? 180  LYS B CA    1 ? 
ATOM   6197  C  C     . LYS B 1 180 ? -19.249 -17.141 -74.213  1    34.549  ? 180  LYS B C     1 ? 
ATOM   6198  O  O     . LYS B 1 180 ? -19.193 -18.356 -74.448  1    25.182  ? 180  LYS B O     1 ? 
ATOM   6199  C  CB    . LYS B 1 180 ? -20.109 -15.648 -76.134  1    34.645  ? 180  LYS B CB    1 ? 
ATOM   6200  C  CG    . LYS B 1 180 ? -21.383 -15.145 -76.853  1    30.933  ? 180  LYS B CG    1 ? 
ATOM   6201  C  CD    . LYS B 1 180 ? -21.174 -14.732 -78.317  1    33.449  ? 180  LYS B CD    1 ? 
ATOM   6202  C  CE    . LYS B 1 180 ? -20.358 -13.515 -78.536  1    27.048  ? 180  LYS B CE    1 ? 
ATOM   6203  N  NZ    . LYS B 1 180 ? -20.162 -13.219 -79.961  1    28.832  ? 180  LYS B NZ    1 ? 
ATOM   6204  N  N     . ILE B 1 181 ? -18.351 -16.475 -73.466  1    31.947  ? 181  ILE B N     1 ? 
ATOM   6205  C  CA    . ILE B 1 181 ? -17.221 -17.128 -72.828  1    34.044  ? 181  ILE B CA    1 ? 
ATOM   6206  C  C     . ILE B 1 181 ? -17.698 -18.153 -71.801  1    35.995  ? 181  ILE B C     1 ? 
ATOM   6207  O  O     . ILE B 1 181 ? -17.221 -19.286 -71.81   1    37.201  ? 181  ILE B O     1 ? 
ATOM   6208  C  CB    . ILE B 1 181 ? -16.234 -16.101 -72.257  1    34.893  ? 181  ILE B CB    1 ? 
ATOM   6209  C  CG1   . ILE B 1 181 ? -15.479 -15.459 -73.413  1    30.437  ? 181  ILE B CG1   1 ? 
ATOM   6210  C  CG2   . ILE B 1 181 ? -15.279 -16.74  -71.228  1    34.14   ? 181  ILE B CG2   1 ? 
ATOM   6211  C  CD1   . ILE B 1 181 ? -14.858 -14.12  -73.077  1    33.695  ? 181  ILE B CD1   1 ? 
ATOM   6212  N  N     . MET B 1 182 ? -18.658 -17.754 -70.963  1    35.173  ? 182  MET B N     1 ? 
ATOM   6213  C  CA    . MET B 1 182 ? -19.27  -18.635 -69.979  1    40.844  ? 182  MET B CA    1 ? 
ATOM   6214  C  C     . MET B 1 182 ? -19.888 -19.855 -70.672  1    39.92   ? 182  MET B C     1 ? 
ATOM   6215  O  O     . MET B 1 182 ? -19.755 -20.973 -70.188  1    34.454  ? 182  MET B O     1 ? 
ATOM   6216  C  CB    . MET B 1 182 ? -20.386 -17.938 -69.185  1    42.313  ? 182  MET B CB    1 ? 
ATOM   6217  C  CG    . MET B 1 182 ? -19.903 -16.955 -68.127  1    58.508  ? 182  MET B CG    1 ? 
ATOM   6218  S  SD    . MET B 1 182 ? -21.185 -16.24  -67.064  1    64.46   ? 182  MET B SD    1 ? 
ATOM   6219  C  CE    . MET B 1 182 ? -21.926 -14.941 -68.077  1    60.927  ? 182  MET B CE    1 ? 
ATOM   6220  N  N     . GLU B 1 183 ? -20.582 -19.623 -71.79   1    35.621  ? 183  GLU B N     1 ? 
ATOM   6221  C  CA    . GLU B 1 183 ? -21.237 -20.704 -72.507  1    39.98   ? 183  GLU B CA    1 ? 
ATOM   6222  C  C     . GLU B 1 183 ? -20.199 -21.747 -72.941  1    40.685  ? 183  GLU B C     1 ? 
ATOM   6223  O  O     . GLU B 1 183 ? -20.413 -22.949 -72.757  1    34.828  ? 183  GLU B O     1 ? 
ATOM   6224  C  CB    . GLU B 1 183 ? -22.082 -20.124 -73.641  1    40.86   ? 183  GLU B CB    1 ? 
ATOM   6225  C  CG    . GLU B 1 183 ? -22.602 -21.169 -74.62   1    42.596  ? 183  GLU B CG    1 ? 
ATOM   6226  C  CD    . GLU B 1 183 ? -23.343 -20.616 -75.827  1    47.515  ? 183  GLU B CD    1 ? 
ATOM   6227  O  OE1   . GLU B 1 183 ? -22.675 -19.927 -76.645  1    50.595  ? 183  GLU B OE1   1 ? 
ATOM   6228  O  OE2   . GLU B 1 183 ? -24.578 -20.848 -75.927  1    42.759  ? 183  GLU B OE2   1 ? 
ATOM   6229  N  N     . PHE B 1 184 ? -19.073 -21.276 -73.495  1    32.854  ? 184  PHE B N     1 ? 
ATOM   6230  C  CA    . PHE B 1 184 ? -17.993 -22.163 -73.891  1    33.033  ? 184  PHE B CA    1 ? 
ATOM   6231  C  C     . PHE B 1 184 ? -17.377 -22.852 -72.673  1    37.113  ? 184  PHE B C     1 ? 
ATOM   6232  O  O     . PHE B 1 184 ? -16.989 -24.018 -72.76   1    37.795  ? 184  PHE B O     1 ? 
ATOM   6233  C  CB    . PHE B 1 184 ? -16.873 -21.365 -74.548  1    30.977  ? 184  PHE B CB    1 ? 
ATOM   6234  C  CG    . PHE B 1 184 ? -15.63  -22.201 -74.846  1    33.142  ? 184  PHE B CG    1 ? 
ATOM   6235  C  CD1   . PHE B 1 184 ? -15.665 -23.228 -75.789  1    35.661  ? 184  PHE B CD1   1 ? 
ATOM   6236  C  CD2   . PHE B 1 184 ? -14.406 -21.902 -74.253  1    30.608  ? 184  PHE B CD2   1 ? 
ATOM   6237  C  CE1   . PHE B 1 184 ? -14.527 -23.987 -76.075  1    32.276  ? 184  PHE B CE1   1 ? 
ATOM   6238  C  CE2   . PHE B 1 184 ? -13.273 -22.664 -74.54   1    37.089  ? 184  PHE B CE2   1 ? 
ATOM   6239  C  CZ    . PHE B 1 184 ? -13.328 -23.694 -75.459  1    32.988  ? 184  PHE B CZ    1 ? 
ATOM   6240  N  N     . ILE B 1 185 ? -17.267 -22.137 -71.541  1    33.45   ? 185  ILE B N     1 ? 
ATOM   6241  C  CA    . ILE B 1 185 ? -16.701 -22.779 -70.354  1    35.512  ? 185  ILE B CA    1 ? 
ATOM   6242  C  C     . ILE B 1 185 ? -17.58  -23.944 -69.892  1    31.328  ? 185  ILE B C     1 ? 
ATOM   6243  O  O     . ILE B 1 185 ? -17.051 -24.98  -69.504  1    32.982  ? 185  ILE B O     1 ? 
ATOM   6244  C  CB    . ILE B 1 185 ? -16.388 -21.774 -69.23   1    35.71   ? 185  ILE B CB    1 ? 
ATOM   6245  C  CG1   . ILE B 1 185 ? -15.119 -20.943 -69.559  1    37.042  ? 185  ILE B CG1   1 ? 
ATOM   6246  C  CG2   . ILE B 1 185 ? -16.246 -22.493 -67.882  1    38.93   ? 185  ILE B CG2   1 ? 
ATOM   6247  C  CD1   . ILE B 1 185 ? -15.013 -19.631 -68.796  1    37.102  ? 185  ILE B CD1   1 ? 
ATOM   6248  N  N     . ARG B 1 186 ? -18.907 -23.757 -69.902  1    32.531  ? 186  ARG B N     1 ? 
ATOM   6249  C  CA    . ARG B 1 186 ? -19.835 -24.811 -69.531  1    37.32   ? 186  ARG B CA    1 ? 
ATOM   6250  C  C     . ARG B 1 186 ? -19.699 -26.025 -70.461  1    44.176  ? 186  ARG B C     1 ? 
ATOM   6251  O  O     . ARG B 1 186 ? -19.696 -27.157 -69.983  1    40.85   ? 186  ARG B O     1 ? 
ATOM   6252  C  CB    . ARG B 1 186 ? -21.271 -24.285 -69.412  1    37.963  ? 186  ARG B CB    1 ? 
ATOM   6253  C  CG    . ARG B 1 186 ? -21.508 -23.356 -68.223  1    42.421  ? 186  ARG B CG    1 ? 
ATOM   6254  C  CD    . ARG B 1 186 ? -22.951 -22.864 -67.96   1    45.195  ? 186  ARG B CD    1 ? 
ATOM   6255  N  NE    . ARG B 1 186 ? -23.521 -22.103 -69.081  1    47.721  ? 186  ARG B NE    1 ? 
ATOM   6256  C  CZ    . ARG B 1 186 ? -23.643 -20.771 -69.266  1    50.607  ? 186  ARG B CZ    1 ? 
ATOM   6257  N  NH1   . ARG B 1 186 ? -23.352 -19.906 -68.301  1    54.688  ? 186  ARG B NH1   1 ? 
ATOM   6258  N  NH2   . ARG B 1 186 ? -24.085 -20.316 -70.434  1    45.465  ? 186  ARG B NH2   1 ? 
ATOM   6259  N  N     . SER B 1 187 ? -19.576 -25.815 -71.785  1    42.384  ? 187  SER B N     1 ? 
ATOM   6260  C  CA    . SER B 1 187 ? -19.518 -26.962 -72.686  1    41.96   ? 187  SER B CA    1 ? 
ATOM   6261  C  C     . SER B 1 187 ? -18.239 -27.767 -72.456  1    45.081  ? 187  SER B C     1 ? 
ATOM   6262  O  O     . SER B 1 187 ? -18.231 -28.989 -72.644  1    44.443  ? 187  SER B O     1 ? 
ATOM   6263  C  CB    . SER B 1 187 ? -19.614 -26.544 -74.13   1    39.325  ? 187  SER B CB    1 ? 
ATOM   6264  O  OG    . SER B 1 187 ? -18.485 -25.758 -74.496  1    41.672  ? 187  SER B OG    1 ? 
ATOM   6265  N  N     . GLU B 1 188 ? -17.138 -27.058 -72.143  1    38.572  ? 188  GLU B N     1 ? 
ATOM   6266  C  CA    . GLU B 1 188 ? -15.865 -27.69  -71.819  1    43.091  ? 188  GLU B CA    1 ? 
ATOM   6267  C  C     . GLU B 1 188 ? -16.019 -28.559 -70.566  1    47.877  ? 188  GLU B C     1 ? 
ATOM   6268  O  O     . GLU B 1 188 ? -15.578 -29.708 -70.563  1    48.243  ? 188  GLU B O     1 ? 
ATOM   6269  C  CB    . GLU B 1 188 ? -14.771 -26.648 -71.597  1    43.23   ? 188  GLU B CB    1 ? 
ATOM   6270  C  CG    . GLU B 1 188 ? -14.273 -25.987 -72.879  1    44.898  ? 188  GLU B CG    1 ? 
ATOM   6271  C  CD    . GLU B 1 188 ? -13.517 -26.981 -73.751  1    42.212  ? 188  GLU B CD    1 ? 
ATOM   6272  O  OE1   . GLU B 1 188 ? -12.408 -27.382 -73.372  1    46.718  ? 188  GLU B OE1   1 ? 
ATOM   6273  O  OE2   . GLU B 1 188 ? -14.05  -27.386 -74.797  1    44.75   ? 188  GLU B OE2   1 ? 
ATOM   6274  N  N     . LYS B 1 189 ? -16.678 -28.007 -69.528  1    43.637  ? 189  LYS B N     1 ? 
ATOM   6275  C  CA    . LYS B 1 189 ? -16.882 -28.683 -68.253  1    49.169  ? 189  LYS B CA    1 ? 
ATOM   6276  C  C     . LYS B 1 189 ? -17.718 -29.935 -68.472  1    49.913  ? 189  LYS B C     1 ? 
ATOM   6277  O  O     . LYS B 1 189 ? -17.654 -30.852 -67.662  1    47.34   ? 189  LYS B O     1 ? 
ATOM   6278  C  CB    . LYS B 1 189 ? -17.719 -27.918 -67.219  1    47.796  ? 189  LYS B CB    1 ? 
ATOM   6279  C  CG    . LYS B 1 189 ? -17.044 -26.823 -66.405  1    59.155  ? 189  LYS B CG    1 ? 
ATOM   6280  C  CD    . LYS B 1 189 ? -17.977 -26.228 -65.352  1    69.126  ? 189  LYS B CD    1 ? 
ATOM   6281  C  CE    . LYS B 1 189 ? -18.082 -27.042 -64.093  1    81.223  ? 189  LYS B CE    1 ? 
ATOM   6282  N  NZ    . LYS B 1 189 ? -19.174 -26.599 -63.217  1    86.848  ? 189  LYS B NZ    1 ? 
ATOM   6283  N  N     . ALA B 1 190 ? -18.531 -29.928 -69.537  1    47.278  ? 190  ALA B N     1 ? 
ATOM   6284  C  CA    . ALA B 1 190 ? -19.5   -30.988 -69.768  1    47.602  ? 190  ALA B CA    1 ? 
ATOM   6285  C  C     . ALA B 1 190 ? -18.872 -32.13  -70.579  1    53.555  ? 190  ALA B C     1 ? 
ATOM   6286  O  O     . ALA B 1 190 ? -19.443 -33.212 -70.677  1    52.728  ? 190  ALA B O     1 ? 
ATOM   6287  C  CB    . ALA B 1 190 ? -20.714 -30.407 -70.461  1    44.736  ? 190  ALA B CB    1 ? 
ATOM   6288  N  N     . LYS B 1 191 ? -17.698 -31.875 -71.174  1    52.302  ? 191  LYS B N     1 ? 
ATOM   6289  C  CA    . LYS B 1 191 ? -16.967 -32.864 -71.955  1    56.168  ? 191  LYS B CA    1 ? 
ATOM   6290  C  C     . LYS B 1 191 ? -16.388 -33.902 -71      1    60.509  ? 191  LYS B C     1 ? 
ATOM   6291  O  O     . LYS B 1 191 ? -15.849 -33.548 -69.956  1    53.682  ? 191  LYS B O     1 ? 
ATOM   6292  C  CB    . LYS B 1 191 ? -15.834 -32.3   -72.83   1    50.466  ? 191  LYS B CB    1 ? 
ATOM   6293  C  CG    . LYS B 1 191 ? -16.274 -31.354 -73.937  1    44.947  ? 191  LYS B CG    1 ? 
ATOM   6294  C  CD    . LYS B 1 191 ? -15.302 -30.968 -75.055  1    51.017  ? 191  LYS B CD    1 ? 
ATOM   6295  C  CE    . LYS B 1 191 ? -13.855 -30.883 -74.668  1    54.859  ? 191  LYS B CE    1 ? 
ATOM   6296  N  NZ    . LYS B 1 191 ? -13.02  -30.56  -75.829  1    58.904  ? 191  LYS B NZ    1 ? 
ATOM   6297  N  N     . PRO B 1 192 ? -16.42  -35.205 -71.36   1    69.988  ? 192  PRO B N     1 ? 
ATOM   6298  C  CA    . PRO B 1 192 ? -16.292 -36.276 -70.369  1    71.138  ? 192  PRO B CA    1 ? 
ATOM   6299  C  C     . PRO B 1 192 ? -14.942 -36.392 -69.661  1    70.895  ? 192  PRO B C     1 ? 
ATOM   6300  O  O     . PRO B 1 192 ? -14.875 -36.908 -68.544  1    78.553  ? 192  PRO B O     1 ? 
ATOM   6301  C  CB    . PRO B 1 192 ? -16.654 -37.531 -71.18   1    81.031  ? 192  PRO B CB    1 ? 
ATOM   6302  C  CG    . PRO B 1 192 ? -17.293 -36.997 -72.449  1    78.601  ? 192  PRO B CG    1 ? 
ATOM   6303  C  CD    . PRO B 1 192 ? -16.557 -35.707 -72.736  1    71.312  ? 192  PRO B CD    1 ? 
ATOM   6304  N  N     . ASP B 1 193 ? -13.876 -35.886 -70.297  1    64.646  ? 193  ASP B N     1 ? 
ATOM   6305  C  CA    A ASP B 1 193 ? -12.514 -35.964 -69.8    0.5  70.567  ? 193  ASP B CA    1 ? 
ATOM   6306  C  CA    B ASP B 1 193 ? -12.575 -35.991 -69.649  0.5  65.937  ? 193  ASP B CA    1 ? 
ATOM   6307  C  C     . ASP B 1 193 ? -12.041 -34.606 -69.278  1    70.226  ? 193  ASP B C     1 ? 
ATOM   6308  O  O     . ASP B 1 193 ? -10.834 -34.381 -69.163  1    66.041  ? 193  ASP B O     1 ? 
ATOM   6309  C  CB    A ASP B 1 193 ? -11.569 -36.353 -70.927  0.5  74.319  ? 193  ASP B CB    1 ? 
ATOM   6310  C  CB    B ASP B 1 193 ? -11.651 -36.954 -70.379  0.5  62.526  ? 193  ASP B CB    1 ? 
ATOM   6311  C  CG    A ASP B 1 193 ? -11.483 -35.354 -72.074  0.5  67.983  ? 193  ASP B CG    1 ? 
ATOM   6312  C  CG    B ASP B 1 193 ? -11.819 -38.417 -69.998  0.5  55.133  ? 193  ASP B CG    1 ? 
ATOM   6313  O  OD1   A ASP B 1 193 ? -12.452 -34.583 -72.251  0.5  63.325  ? 193  ASP B OD1   1 ? 
ATOM   6314  O  OD1   B ASP B 1 193 ? -12.453 -38.678 -68.954  0.5  49.602  ? 193  ASP B OD1   1 ? 
ATOM   6315  O  OD2   A ASP B 1 193 ? -10.437 -35.336 -72.761  0.5  65.761  ? 193  ASP B OD2   1 ? 
ATOM   6316  O  OD2   B ASP B 1 193 ? -11.332 -39.274 -70.758  0.5  50.732  ? 193  ASP B OD2   1 ? 
ATOM   6317  N  N     . HIS B 1 194 ? -12.97  -33.681 -69.016  1    69.546  ? 194  HIS B N     1 ? 
ATOM   6318  C  CA    . HIS B 1 194 ? -12.568 -32.346 -68.602  1    59.402  ? 194  HIS B CA    1 ? 
ATOM   6319  C  C     . HIS B 1 194 ? -11.638 -32.443 -67.397  1    50.431  ? 194  HIS B C     1 ? 
ATOM   6320  O  O     . HIS B 1 194 ? -12.014 -32.979 -66.359  1    52.067  ? 194  HIS B O     1 ? 
ATOM   6321  C  CB    . HIS B 1 194 ? -13.77  -31.442 -68.299  1    55.216  ? 194  HIS B CB    1 ? 
ATOM   6322  C  CG    . HIS B 1 194 ? -13.306 -30.063 -67.972  1    61.082  ? 194  HIS B CG    1 ? 
ATOM   6323  N  ND1   . HIS B 1 194 ? -12.803 -29.216 -68.939  1    58.417  ? 194  HIS B ND1   1 ? 
ATOM   6324  C  CD2   . HIS B 1 194 ? -13.179 -29.414 -66.8    1    60.684  ? 194  HIS B CD2   1 ? 
ATOM   6325  C  CE1   . HIS B 1 194 ? -12.424 -28.079 -68.371  1    59.888  ? 194  HIS B CE1   1 ? 
ATOM   6326  N  NE2   . HIS B 1 194 ? -12.648 -28.175 -67.074  1    55.811  ? 194  HIS B NE2   1 ? 
ATOM   6327  N  N     . ASP B 1 195 ? -10.421 -31.927 -67.565  1    49.93   ? 195  ASP B N     1 ? 
ATOM   6328  C  CA    . ASP B 1 195 ? -9.435  -31.907 -66.496  1    48.15   ? 195  ASP B CA    1 ? 
ATOM   6329  C  C     . ASP B 1 195 ? -9.748  -30.808 -65.475  1    51.045  ? 195  ASP B C     1 ? 
ATOM   6330  O  O     . ASP B 1 195 ? -9.598  -29.612 -65.748  1    50.177  ? 195  ASP B O     1 ? 
ATOM   6331  C  CB    . ASP B 1 195 ? -8.024  -31.793 -67.048  1    49.492  ? 195  ASP B CB    1 ? 
ATOM   6332  C  CG    . ASP B 1 195 ? -6.928  -31.753 -65.996  1    47.396  ? 195  ASP B CG    1 ? 
ATOM   6333  O  OD1   . ASP B 1 195 ? -7.252  -31.619 -64.796  1    49.246  ? 195  ASP B OD1   1 ? 
ATOM   6334  O  OD2   . ASP B 1 195 ? -5.759  -31.9   -66.385  1    53.245  ? 195  ASP B OD2   1 ? 
ATOM   6335  N  N     . PRO B 1 196 ? -10.099 -31.18  -64.225  1    48.483  ? 196  PRO B N     1 ? 
ATOM   6336  C  CA    . PRO B 1 196 ? -10.582 -30.205 -63.252  1    47.537  ? 196  PRO B CA    1 ? 
ATOM   6337  C  C     . PRO B 1 196 ? -9.462  -29.251 -62.855  1    46.457  ? 196  PRO B C     1 ? 
ATOM   6338  O  O     . PRO B 1 196 ? -9.729  -28.224 -62.246  1    50.752  ? 196  PRO B O     1 ? 
ATOM   6339  C  CB    . PRO B 1 196 ? -11.112 -31.066 -62.095  1    53.683  ? 196  PRO B CB    1 ? 
ATOM   6340  C  CG    . PRO B 1 196 ? -10.31  -32.339 -62.198  1    57.041  ? 196  PRO B CG    1 ? 
ATOM   6341  C  CD    . PRO B 1 196 ? -10.028 -32.549 -63.688  1    54.327  ? 196  PRO B CD    1 ? 
ATOM   6342  N  N     . ASN B 1 197 ? -8.228  -29.573 -63.267  1    44.889  ? 197  ASN B N     1 ? 
ATOM   6343  C  CA    . ASN B 1 197 ? -7.071  -28.723 -63.035  1    50.19   ? 197  ASN B CA    1 ? 
ATOM   6344  C  C     . ASN B 1 197 ? -6.645  -27.956 -64.29   1    48.57   ? 197  ASN B C     1 ? 
ATOM   6345  O  O     . ASN B 1 197 ? -5.516  -27.459 -64.349  1    49.375  ? 197  ASN B O     1 ? 
ATOM   6346  C  CB    . ASN B 1 197 ? -5.909  -29.503 -62.426  1    60.261  ? 197  ASN B CB    1 ? 
ATOM   6347  C  CG    . ASN B 1 197 ? -6.176  -29.837 -60.974  1    71.453  ? 197  ASN B CG    1 ? 
ATOM   6348  O  OD1   . ASN B 1 197 ? -6.538  -28.956 -60.182  1    74.181  ? 197  ASN B OD1   1 ? 
ATOM   6349  N  ND2   . ASN B 1 197 ? -6.024  -31.1   -60.608  1    73.05   ? 197  ASN B ND2   1 ? 
ATOM   6350  N  N     . THR B 1 198 ? -7.539  -27.853 -65.284  1    42.377  ? 198  THR B N     1 ? 
ATOM   6351  C  CA    . THR B 1 198 ? -7.338  -26.929 -66.392  1    35.794  ? 198  THR B CA    1 ? 
ATOM   6352  C  C     . THR B 1 198 ? -7.056  -25.533 -65.834  1    36.065  ? 198  THR B C     1 ? 
ATOM   6353  O  O     . THR B 1 198 ? -7.788  -25.048 -64.973  1    35.744  ? 198  THR B O     1 ? 
ATOM   6354  C  CB    . THR B 1 198 ? -8.577  -26.933 -67.29   1    39.594  ? 198  THR B CB    1 ? 
ATOM   6355  O  OG1   . THR B 1 198 ? -8.728  -28.283 -67.739  1    37.935  ? 198  THR B OG1   1 ? 
ATOM   6356  C  CG2   . THR B 1 198 ? -8.442  -26.001 -68.485  1    39.381  ? 198  THR B CG2   1 ? 
ATOM   6357  N  N     . ARG B 1 199 ? -6.008  -24.882 -66.36   1    33.423  ? 199  ARG B N     1 ? 
ATOM   6358  C  CA    . ARG B 1 199 ? -5.562  -23.568 -65.918  1    36.96   ? 199  ARG B CA    1 ? 
ATOM   6359  C  C     . ARG B 1 199 ? -6.119  -22.466 -66.828  1    35.924  ? 199  ARG B C     1 ? 
ATOM   6360  O  O     . ARG B 1 199 ? -5.636  -22.257 -67.925  1    42.542  ? 199  ARG B O     1 ? 
ATOM   6361  C  CB    . ARG B 1 199 ? -4.029  -23.576 -65.855  1    35.561  ? 199  ARG B CB    1 ? 
ATOM   6362  C  CG    . ARG B 1 199 ? -3.549  -24.468 -64.716  1    39.963  ? 199  ARG B CG    1 ? 
ATOM   6363  C  CD    . ARG B 1 199 ? -2.084  -24.844 -64.927  1    47.21   ? 199  ARG B CD    1 ? 
ATOM   6364  N  NE    . ARG B 1 199 ? -1.869  -25.511 -66.217  1    58.756  ? 199  ARG B NE    1 ? 
ATOM   6365  C  CZ    . ARG B 1 199 ? -0.701  -25.839 -66.768  1    64.444  ? 199  ARG B CZ    1 ? 
ATOM   6366  N  NH1   . ARG B 1 199 ? 0.429   -25.724 -66.082  1    70.744  ? 199  ARG B NH1   1 ? 
ATOM   6367  N  NH2   . ARG B 1 199 ? -0.669  -26.296 -68.008  1    51.934  ? 199  ARG B NH2   1 ? 
ATOM   6368  N  N     . HIS B 1 200 ? -7.154  -21.763 -66.357  1    40.757  ? 200  HIS B N     1 ? 
ATOM   6369  C  CA    . HIS B 1 200 ? -7.847  -20.755 -67.141  1    40.47   ? 200  HIS B CA    1 ? 
ATOM   6370  C  C     . HIS B 1 200 ? -7.272  -19.37  -66.835  1    44.519  ? 200  HIS B C     1 ? 
ATOM   6371  O  O     . HIS B 1 200 ? -6.953  -19.078 -65.687  1    46.6    ? 200  HIS B O     1 ? 
ATOM   6372  C  CB    . HIS B 1 200 ? -9.338  -20.75  -66.778  1    39.049  ? 200  HIS B CB    1 ? 
ATOM   6373  C  CG    . HIS B 1 200 ? -10.05  -22.061 -66.847  1    43.233  ? 200  HIS B CG    1 ? 
ATOM   6374  N  ND1   . HIS B 1 200 ? -10.724 -22.518 -67.965  1    43.171  ? 200  HIS B ND1   1 ? 
ATOM   6375  C  CD2   . HIS B 1 200 ? -10.216 -23.006 -65.899  1    45.951  ? 200  HIS B CD2   1 ? 
ATOM   6376  C  CE1   . HIS B 1 200 ? -11.269 -23.701 -67.689  1    45.71   ? 200  HIS B CE1   1 ? 
ATOM   6377  N  NE2   . HIS B 1 200 ? -10.976 -24.014 -66.429  1    42.331  ? 200  HIS B NE2   1 ? 
ATOM   6378  N  N     . CYS B 1 201 ? -7.159  -18.515 -67.864  1    42.322  ? 201  CYS B N     1 ? 
ATOM   6379  C  CA    . CYS B 1 201 ? -6.82   -17.108 -67.713  1    40.336  ? 201  CYS B CA    1 ? 
ATOM   6380  C  C     . CYS B 1 201 ? -7.857  -16.29  -68.483  1    45.116  ? 201  CYS B C     1 ? 
ATOM   6381  O  O     . CYS B 1 201 ? -8.151  -16.584 -69.644  1    40.716  ? 201  CYS B O     1 ? 
ATOM   6382  C  CB    . CYS B 1 201 ? -5.399  -16.811 -68.179  1    38.522  ? 201  CYS B CB    1 ? 
ATOM   6383  S  SG    . CYS B 1 201 ? -4.93   -15.06  -68.022  1    42.452  ? 201  CYS B SG    1 ? 
ATOM   6384  N  N     . LEU B 1 202 ? -8.441  -15.298 -67.797  1    42.213  ? 202  LEU B N     1 ? 
ATOM   6385  C  CA    . LEU B 1 202 ? -9.483  -14.434 -68.335  1    38.754  ? 202  LEU B CA    1 ? 
ATOM   6386  C  C     . LEU B 1 202 ? -8.955  -13.01  -68.289  1    44.325  ? 202  LEU B C     1 ? 
ATOM   6387  O  O     . LEU B 1 202 ? -8.52   -12.564 -67.224  1    45.065  ? 202  LEU B O     1 ? 
ATOM   6388  C  CB    . LEU B 1 202 ? -10.727 -14.605 -67.466  1    33.993  ? 202  LEU B CB    1 ? 
ATOM   6389  C  CG    . LEU B 1 202 ? -11.873 -13.608 -67.669  1    35.37   ? 202  LEU B CG    1 ? 
ATOM   6390  C  CD1   . LEU B 1 202 ? -12.364 -13.581 -69.115  1    40.114  ? 202  LEU B CD1   1 ? 
ATOM   6391  C  CD2   . LEU B 1 202 ? -13.06  -13.987 -66.775  1    35.651  ? 202  LEU B CD2   1 ? 
ATOM   6392  N  N     . TYR B 1 203 ? -8.967  -12.316 -69.437  1    37.914  ? 203  TYR B N     1 ? 
ATOM   6393  C  CA    . TYR B 1 203 ? -8.349  -11.004 -69.496  1    40.278  ? 203  TYR B CA    1 ? 
ATOM   6394  C  C     . TYR B 1 203 ? -9.344  -9.954  -68.997  1    48.009  ? 203  TYR B C     1 ? 
ATOM   6395  O  O     . TYR B 1 203 ? -10.397 -9.749  -69.6    1    50.545  ? 203  TYR B O     1 ? 
ATOM   6396  C  CB    . TYR B 1 203 ? -7.695  -10.695 -70.847  1    35.606  ? 203  TYR B CB    1 ? 
ATOM   6397  C  CG    . TYR B 1 203 ? -7.195  -9.261  -70.976  1    38.173  ? 203  TYR B CG    1 ? 
ATOM   6398  C  CD1   . TYR B 1 203 ? -5.939  -8.868  -70.513  1    40.053  ? 203  TYR B CD1   1 ? 
ATOM   6399  C  CD2   . TYR B 1 203 ? -7.986  -8.292  -71.583  1    43.386  ? 203  TYR B CD2   1 ? 
ATOM   6400  C  CE1   . TYR B 1 203 ? -5.488  -7.556  -70.633  1    38.894  ? 203  TYR B CE1   1 ? 
ATOM   6401  C  CE2   . TYR B 1 203 ? -7.546  -6.985  -71.725  1    42.835  ? 203  TYR B CE2   1 ? 
ATOM   6402  C  CZ    . TYR B 1 203 ? -6.296  -6.614  -71.257  1    43.867  ? 203  TYR B CZ    1 ? 
ATOM   6403  O  OH    . TYR B 1 203 ? -5.928  -5.304  -71.438  1    46.281  ? 203  TYR B OH    1 ? 
ATOM   6404  N  N     . GLY B 1 204 ? -8.982  -9.272  -67.898  1    48.956  ? 204  GLY B N     1 ? 
ATOM   6405  C  CA    . GLY B 1 204 ? -9.815  -8.221  -67.334  1    51.742  ? 204  GLY B CA    1 ? 
ATOM   6406  C  C     . GLY B 1 204 ? -9.947  -8.34   -65.815  1    55.94   ? 204  GLY B C     1 ? 
ATOM   6407  O  O     . GLY B 1 204 ? -9.638  -9.378  -65.23   1    51.881  ? 204  GLY B O     1 ? 
ATOM   6408  N  N     . LEU B 1 205 ? -10.435 -7.26   -65.189  1    48.54   ? 205  LEU B N     1 ? 
ATOM   6409  C  CA    . LEU B 1 205 ? -10.492 -7.158  -63.74   1    51.043  ? 205  LEU B CA    1 ? 
ATOM   6410  C  C     . LEU B 1 205 ? -11.892 -6.75   -63.3    1    50.966  ? 205  LEU B C     1 ? 
ATOM   6411  O  O     . LEU B 1 205 ? -12.097 -6.562  -62.112  1    50.736  ? 205  LEU B O     1 ? 
ATOM   6412  C  CB    . LEU B 1 205 ? -9.442  -6.184  -63.192  1    44.661  ? 205  LEU B CB    1 ? 
ATOM   6413  C  CG    . LEU B 1 205 ? -7.976  -6.568  -63.427  1    50.745  ? 205  LEU B CG    1 ? 
ATOM   6414  C  CD1   . LEU B 1 205 ? -7.021  -5.572  -62.753  1    48.978  ? 205  LEU B CD1   1 ? 
ATOM   6415  C  CD2   . LEU B 1 205 ? -7.711  -8.018  -62.99   1    48.63   ? 205  LEU B CD2   1 ? 
ATOM   6416  N  N     . ASP B 1 206 ? -12.828 -6.613  -64.255  1    52.26   ? 206  ASP B N     1 ? 
ATOM   6417  C  CA    . ASP B 1 206 ? -14.145 -6.035  -64.004  1    52.832  ? 206  ASP B CA    1 ? 
ATOM   6418  C  C     . ASP B 1 206 ? -15.005 -6.967  -63.152  1    53.999  ? 206  ASP B C     1 ? 
ATOM   6419  O  O     . ASP B 1 206 ? -14.788 -8.182  -63.134  1    50.274  ? 206  ASP B O     1 ? 
ATOM   6420  C  CB    . ASP B 1 206 ? -14.848 -5.649  -65.297  1    56.787  ? 206  ASP B CB    1 ? 
ATOM   6421  C  CG    . ASP B 1 206 ? -14.015 -4.793  -66.239  1    60.981  ? 206  ASP B CG    1 ? 
ATOM   6422  O  OD1   . ASP B 1 206 ? -13.145 -5.358  -66.925  1    62.315  ? 206  ASP B OD1   1 ? 
ATOM   6423  O  OD2   . ASP B 1 206 ? -14.215 -3.562  -66.243  1    68.176  ? 206  ASP B OD2   1 ? 
ATOM   6424  N  N     . ALA B 1 207 ? -15.987 -6.368  -62.459  1    46.311  ? 207  ALA B N     1 ? 
ATOM   6425  C  CA    . ALA B 1 207 ? -16.826 -7.074  -61.504  1    50.094  ? 207  ALA B CA    1 ? 
ATOM   6426  C  C     . ALA B 1 207 ? -17.443 -8.323  -62.137  1    56.098  ? 207  ALA B C     1 ? 
ATOM   6427  O  O     . ALA B 1 207 ? -17.429 -9.394  -61.522  1    53.662  ? 207  ALA B O     1 ? 
ATOM   6428  C  CB    . ALA B 1 207 ? -17.885 -6.143  -60.958  1    51.313  ? 207  ALA B CB    1 ? 
ATOM   6429  N  N     . ASP B 1 208 ? -17.971 -8.17   -63.363  1    46.499  ? 208  ASP B N     1 ? 
ATOM   6430  C  CA    . ASP B 1 208 ? -18.698 -9.233  -64.049  1    50.977  ? 208  ASP B CA    1 ? 
ATOM   6431  C  C     . ASP B 1 208 ? -17.758 -10.399 -64.382  1    39.524  ? 208  ASP B C     1 ? 
ATOM   6432  O  O     . ASP B 1 208 ? -18.185 -11.549 -64.404  1    38.921  ? 208  ASP B O     1 ? 
ATOM   6433  C  CB    . ASP B 1 208 ? -19.553 -8.704  -65.198  1    60.376  ? 208  ASP B CB    1 ? 
ATOM   6434  C  CG    . ASP B 1 208 ? -18.82  -8.243  -66.457  1    73.667  ? 208  ASP B CG    1 ? 
ATOM   6435  O  OD1   . ASP B 1 208 ? -18.006 -7.291  -66.368  1    66.91   ? 208  ASP B OD1   1 ? 
ATOM   6436  O  OD2   . ASP B 1 208 ? -19.07  -8.839  -67.538  1    89.631  ? 208  ASP B OD2   1 ? 
ATOM   6437  N  N     . LEU B 1 209 ? -16.485 -10.089 -64.646  1    35.431  ? 209  LEU B N     1 ? 
ATOM   6438  C  CA    . LEU B 1 209 ? -15.459 -11.085 -64.907  1    41.99   ? 209  LEU B CA    1 ? 
ATOM   6439  C  C     . LEU B 1 209 ? -15.174 -11.908 -63.645  1    45.626  ? 209  LEU B C     1 ? 
ATOM   6440  O  O     . LEU B 1 209 ? -15.116 -13.136 -63.695  1    45.558  ? 209  LEU B O     1 ? 
ATOM   6441  C  CB    . LEU B 1 209 ? -14.199 -10.418 -65.47   1    39.195  ? 209  LEU B CB    1 ? 
ATOM   6442  C  CG    . LEU B 1 209 ? -14.369 -9.759  -66.842  1    42.175  ? 209  LEU B CG    1 ? 
ATOM   6443  C  CD1   . LEU B 1 209 ? -13.053 -9.417  -67.526  1    44.924  ? 209  LEU B CD1   1 ? 
ATOM   6444  C  CD2   . LEU B 1 209 ? -15.235 -10.626 -67.736  1    36.787  ? 209  LEU B CD2   1 ? 
ATOM   6445  N  N     . ILE B 1 210 ? -15.02  -11.22  -62.506  1    44.183  ? 210  ILE B N     1 ? 
ATOM   6446  C  CA    . ILE B 1 210 ? -14.756 -11.898 -61.248  1    41.619  ? 210  ILE B CA    1 ? 
ATOM   6447  C  C     . ILE B 1 210 ? -15.912 -12.834 -60.948  1    34.841  ? 210  ILE B C     1 ? 
ATOM   6448  O  O     . ILE B 1 210 ? -15.687 -13.976 -60.584  1    37.56   ? 210  ILE B O     1 ? 
ATOM   6449  C  CB    . ILE B 1 210 ? -14.529 -10.895 -60.104  1    43.318  ? 210  ILE B CB    1 ? 
ATOM   6450  C  CG1   . ILE B 1 210 ? -13.245 -10.083 -60.343  1    44.686  ? 210  ILE B CG1   1 ? 
ATOM   6451  C  CG2   . ILE B 1 210 ? -14.528 -11.621 -58.757  1    37.481  ? 210  ILE B CG2   1 ? 
ATOM   6452  C  CD1   . ILE B 1 210 ? -13.104 -8.849  -59.462  1    48.609  ? 210  ILE B CD1   1 ? 
ATOM   6453  N  N     . MET B 1 211 ? -17.141 -12.338 -61.11   1    35.078  ? 211  MET B N     1 ? 
ATOM   6454  C  CA    . MET B 1 211 ? -18.326 -13.14  -60.851  1    37.024  ? 211  MET B CA    1 ? 
ATOM   6455  C  C     . MET B 1 211 ? -18.372 -14.331 -61.809  1    42.547  ? 211  MET B C     1 ? 
ATOM   6456  O  O     . MET B 1 211 ? -18.796 -15.422 -61.429  1    43.241  ? 211  MET B O     1 ? 
ATOM   6457  C  CB    . MET B 1 211 ? -19.601 -12.303 -61      1    37.385  ? 211  MET B CB    1 ? 
ATOM   6458  C  CG    . MET B 1 211 ? -19.812 -11.279 -59.9    1    46.644  ? 211  MET B CG    1 ? 
ATOM   6459  S  SD    . MET B 1 211 ? -19.618 -12.019 -58.268  1    54.827  ? 211  MET B SD    1 ? 
ATOM   6460  C  CE    . MET B 1 211 ? -20.631 -10.82  -57.393  1    55.709  ? 211  MET B CE    1 ? 
ATOM   6461  N  N     . LEU B 1 212 ? -17.931 -14.103 -63.054  1    41.778  ? 212  LEU B N     1 ? 
ATOM   6462  C  CA    . LEU B 1 212 ? -17.912 -15.117 -64.102  1    41.882  ? 212  LEU B CA    1 ? 
ATOM   6463  C  C     . LEU B 1 212 ? -16.928 -16.224 -63.725  1    35.628  ? 212  LEU B C     1 ? 
ATOM   6464  O  O     . LEU B 1 212 ? -17.291 -17.402 -63.717  1    33.3    ? 212  LEU B O     1 ? 
ATOM   6465  C  CB    . LEU B 1 212 ? -17.502 -14.35  -65.363  1    44.452  ? 212  LEU B CB    1 ? 
ATOM   6466  C  CG    . LEU B 1 212 ? -17.445 -15.087 -66.705  1    50.97   ? 212  LEU B CG    1 ? 
ATOM   6467  C  CD1   . LEU B 1 212 ? -17.478 -14.05  -67.832  1    47.684  ? 212  LEU B CD1   1 ? 
ATOM   6468  C  CD2   . LEU B 1 212 ? -16.224 -15.976 -66.901  1    47.433  ? 212  LEU B CD2   1 ? 
ATOM   6469  N  N     . GLY B 1 213 ? -15.686 -15.844 -63.407  1    36.095  ? 213  GLY B N     1 ? 
ATOM   6470  C  CA    . GLY B 1 213 ? -14.676 -16.792 -62.934  1    39.692  ? 213  GLY B CA    1 ? 
ATOM   6471  C  C     . GLY B 1 213 ? -15.133 -17.655 -61.747  1    41.052  ? 213  GLY B C     1 ? 
ATOM   6472  O  O     . GLY B 1 213 ? -14.831 -18.843 -61.717  1    45.978  ? 213  GLY B O     1 ? 
ATOM   6473  N  N     . LEU B 1 214 ? -15.877 -17.074 -60.787  1    40.928  ? 214  LEU B N     1 ? 
ATOM   6474  C  CA    . LEU B 1 214 ? -16.357 -17.79  -59.607  1    37.023  ? 214  LEU B CA    1 ? 
ATOM   6475  C  C     . LEU B 1 214 ? -17.55  -18.673 -59.963  1    38.604  ? 214  LEU B C     1 ? 
ATOM   6476  O  O     . LEU B 1 214 ? -17.711 -19.779 -59.425  1    35.071  ? 214  LEU B O     1 ? 
ATOM   6477  C  CB    . LEU B 1 214 ? -16.728 -16.824 -58.476  1    34.979  ? 214  LEU B CB    1 ? 
ATOM   6478  C  CG    . LEU B 1 214 ? -15.561 -16.03  -57.877  1    38.755  ? 214  LEU B CG    1 ? 
ATOM   6479  C  CD1   . LEU B 1 214 ? -16.073 -14.941 -56.968  1    37.826  ? 214  LEU B CD1   1 ? 
ATOM   6480  C  CD2   . LEU B 1 214 ? -14.519 -16.885 -57.173  1    36.491  ? 214  LEU B CD2   1 ? 
ATOM   6481  N  N     . THR B 1 215 ? -18.419 -18.163 -60.844  1    34.857  ? 215  THR B N     1 ? 
ATOM   6482  C  CA    . THR B 1 215 ? -19.611 -18.92  -61.212  1    41.896  ? 215  THR B CA    1 ? 
ATOM   6483  C  C     . THR B 1 215 ? -19.215 -20.201 -61.95   1    37.353  ? 215  THR B C     1 ? 
ATOM   6484  O  O     . THR B 1 215 ? -19.96  -21.176 -61.9    1    38.99   ? 215  THR B O     1 ? 
ATOM   6485  C  CB    . THR B 1 215 ? -20.571 -18.063 -62.044  1    49.78   ? 215  THR B CB    1 ? 
ATOM   6486  O  OG1   . THR B 1 215 ? -21.097 -17.132 -61.103  1    50.655  ? 215  THR B OG1   1 ? 
ATOM   6487  C  CG2   . THR B 1 215 ? -21.762 -18.852 -62.558  1    55.99   ? 215  THR B CG2   1 ? 
ATOM   6488  N  N     . SER B 1 216 ? -18.046 -20.177 -62.606  1    32.662  ? 216  SER B N     1 ? 
ATOM   6489  C  CA    . SER B 1 216 ? -17.513 -21.321 -63.325  1    40.8    ? 216  SER B CA    1 ? 
ATOM   6490  C  C     . SER B 1 216 ? -17.266 -22.512 -62.403  1    45.759  ? 216  SER B C     1 ? 
ATOM   6491  O  O     . SER B 1 216 ? -17.462 -23.655 -62.818  1    44.607  ? 216  SER B O     1 ? 
ATOM   6492  C  CB    . SER B 1 216 ? -16.277 -20.969 -64.12   1    39.883  ? 216  SER B CB    1 ? 
ATOM   6493  O  OG    . SER B 1 216 ? -15.107 -20.993 -63.319  1    47.755  ? 216  SER B OG    1 ? 
ATOM   6494  N  N     . HIS B 1 217 ? -16.855 -22.237 -61.153  1    46.84   ? 217  HIS B N     1 ? 
ATOM   6495  C  CA    . HIS B 1 217 ? -16.532 -23.259 -60.164  1    41.381  ? 217  HIS B CA    1 ? 
ATOM   6496  C  C     . HIS B 1 217 ? -15.327 -24.081 -60.613  1    43.776  ? 217  HIS B C     1 ? 
ATOM   6497  O  O     . HIS B 1 217 ? -15.151 -25.22  -60.189  1    47.26   ? 217  HIS B O     1 ? 
ATOM   6498  C  CB    . HIS B 1 217 ? -17.726 -24.174 -59.888  1    40.836  ? 217  HIS B CB    1 ? 
ATOM   6499  C  CG    . HIS B 1 217 ? -18.752 -23.505 -59.049  1    43.415  ? 217  HIS B CG    1 ? 
ATOM   6500  N  ND1   . HIS B 1 217 ? -18.652 -23.479 -57.674  1    39.72   ? 217  HIS B ND1   1 ? 
ATOM   6501  C  CD2   . HIS B 1 217 ? -19.849 -22.797 -59.365  1    38.746  ? 217  HIS B CD2   1 ? 
ATOM   6502  C  CE1   . HIS B 1 217 ? -19.686 -22.817 -57.175  1    41.921  ? 217  HIS B CE1   1 ? 
ATOM   6503  N  NE2   . HIS B 1 217 ? -20.416 -22.381 -58.182  1    45.897  ? 217  HIS B NE2   1 ? 
ATOM   6504  N  N     . GLU B 1 218 ? -14.504 -23.497 -61.481  1    44.32   ? 218  GLU B N     1 ? 
ATOM   6505  C  CA    . GLU B 1 218 ? -13.273 -24.14  -61.896  1    48.02   ? 218  GLU B CA    1 ? 
ATOM   6506  C  C     . GLU B 1 218 ? -12.198 -23.858 -60.852  1    50.394  ? 218  GLU B C     1 ? 
ATOM   6507  O  O     . GLU B 1 218 ? -12.061 -22.723 -60.403  1    53.336  ? 218  GLU B O     1 ? 
ATOM   6508  C  CB    . GLU B 1 218 ? -12.904 -23.664 -63.299  1    46.73   ? 218  GLU B CB    1 ? 
ATOM   6509  C  CG    . GLU B 1 218 ? -13.795 -24.272 -64.383  1    56.482  ? 218  GLU B CG    1 ? 
ATOM   6510  C  CD    . GLU B 1 218 ? -13.522 -25.739 -64.705  1    55.513  ? 218  GLU B CD    1 ? 
ATOM   6511  O  OE1   . GLU B 1 218 ? -14.385 -26.57  -64.343  1    54.185  ? 218  GLU B OE1   1 ? 
ATOM   6512  O  OE2   . GLU B 1 218 ? -12.458 -26.054 -65.307  1    49.355  ? 218  GLU B OE2   1 ? 
ATOM   6513  N  N     . ALA B 1 219 ? -11.44  -24.904 -60.489  1    51.179  ? 219  ALA B N     1 ? 
ATOM   6514  C  CA    . ALA B 1 219 ? -10.429 -24.825 -59.447  1    48.185  ? 219  ALA B CA    1 ? 
ATOM   6515  C  C     . ALA B 1 219 ? -9.406  -23.737 -59.755  1    44.298  ? 219  ALA B C     1 ? 
ATOM   6516  O  O     . ALA B 1 219 ? -9.13   -22.904 -58.901  1    50.207  ? 219  ALA B O     1 ? 
ATOM   6517  C  CB    . ALA B 1 219 ? -9.785  -26.184 -59.232  1    53.662  ? 219  ALA B CB    1 ? 
ATOM   6518  N  N     . HIS B 1 220 ? -8.873  -23.717 -60.983  1    46.396  ? 220  HIS B N     1 ? 
ATOM   6519  C  CA    . HIS B 1 220 ? -7.772  -22.826 -61.322  1    41.508  ? 220  HIS B CA    1 ? 
ATOM   6520  C  C     . HIS B 1 220 ? -8.195  -21.816 -62.384  1    44.199  ? 220  HIS B C     1 ? 
ATOM   6521  O  O     . HIS B 1 220 ? -8.104  -22.06  -63.583  1    44.25   ? 220  HIS B O     1 ? 
ATOM   6522  C  CB    . HIS B 1 220 ? -6.52   -23.612 -61.716  1    37.312  ? 220  HIS B CB    1 ? 
ATOM   6523  C  CG    . HIS B 1 220 ? -5.993  -24.467 -60.614  1    51.893  ? 220  HIS B CG    1 ? 
ATOM   6524  N  ND1   . HIS B 1 220 ? -5.036  -24.035 -59.715  1    51.642  ? 220  HIS B ND1   1 ? 
ATOM   6525  C  CD2   . HIS B 1 220 ? -6.279  -25.741 -60.284  1    53.029  ? 220  HIS B CD2   1 ? 
ATOM   6526  C  CE1   . HIS B 1 220 ? -4.761  -25.019 -58.871  1    56.446  ? 220  HIS B CE1   1 ? 
ATOM   6527  N  NE2   . HIS B 1 220 ? -5.505  -26.062 -59.199  1    58.027  ? 220  HIS B NE2   1 ? 
ATOM   6528  N  N     . PHE B 1 221 ? -8.634  -20.655 -61.911  1    45.195  ? 221  PHE B N     1 ? 
ATOM   6529  C  CA    . PHE B 1 221 ? -9.122  -19.595 -62.757  1    38.82   ? 221  PHE B CA    1 ? 
ATOM   6530  C  C     . PHE B 1 221 ? -8.451  -18.301 -62.324  1    45.473  ? 221  PHE B C     1 ? 
ATOM   6531  O  O     . PHE B 1 221 ? -8.542  -17.914 -61.16   1    53.921  ? 221  PHE B O     1 ? 
ATOM   6532  C  CB    . PHE B 1 221 ? -10.615 -19.518 -62.462  1    39.525  ? 221  PHE B CB    1 ? 
ATOM   6533  C  CG    . PHE B 1 221 ? -11.321 -18.887 -63.645  1    44.282  ? 221  PHE B CG    1 ? 
ATOM   6534  C  CD1   . PHE B 1 221 ? -11.113 -17.549 -63.952  1    39.257  ? 221  PHE B CD1   1 ? 
ATOM   6535  C  CD2   . PHE B 1 221 ? -12.149 -19.651 -64.47   1    43.868  ? 221  PHE B CD2   1 ? 
ATOM   6536  C  CE1   . PHE B 1 221 ? -11.728 -16.973 -65.05   1    42.144  ? 221  PHE B CE1   1 ? 
ATOM   6537  C  CE2   . PHE B 1 221 ? -12.766 -19.076 -65.569  1    49.045  ? 221  PHE B CE2   1 ? 
ATOM   6538  C  CZ    . PHE B 1 221 ? -12.556 -17.738 -65.856  1    48.772  ? 221  PHE B CZ    1 ? 
ATOM   6539  N  N     . SER B 1 222 ? -7.801  -17.627 -63.272  1    41.406  ? 222  SER B N     1 ? 
ATOM   6540  C  CA    . SER B 1 222 ? -7.11   -16.392 -62.962  1    47.461  ? 222  SER B CA    1 ? 
ATOM   6541  C  C     . SER B 1 222 ? -7.534  -15.287 -63.92   1    50.279  ? 222  SER B C     1 ? 
ATOM   6542  O  O     . SER B 1 222 ? -7.752  -15.543 -65.104  1    47.114  ? 222  SER B O     1 ? 
ATOM   6543  C  CB    . SER B 1 222 ? -5.626  -16.602 -62.986  1    46.335  ? 222  SER B CB    1 ? 
ATOM   6544  O  OG    . SER B 1 222 ? -5.317  -17.814 -62.318  1    49.311  ? 222  SER B OG    1 ? 
ATOM   6545  N  N     . LEU B 1 223 ? -7.648  -14.067 -63.372  1    45.801  ? 223  LEU B N     1 ? 
ATOM   6546  C  CA    . LEU B 1 223 ? -7.855  -12.856 -64.145  1    40.376  ? 223  LEU B CA    1 ? 
ATOM   6547  C  C     . LEU B 1 223 ? -6.528  -12.115 -64.24   1    45.898  ? 223  LEU B C     1 ? 
ATOM   6548  O  O     . LEU B 1 223 ? -5.711  -12.153 -63.318  1    55.178  ? 223  LEU B O     1 ? 
ATOM   6549  C  CB    . LEU B 1 223 ? -8.962  -12.016 -63.518  1    33.966  ? 223  LEU B CB    1 ? 
ATOM   6550  C  CG    . LEU B 1 223 ? -10.37  -12.614 -63.604  1    36.058  ? 223  LEU B CG    1 ? 
ATOM   6551  C  CD1   . LEU B 1 223 ? -10.608 -13.898 -62.8    1    44.647  ? 223  LEU B CD1   1 ? 
ATOM   6552  C  CD2   . LEU B 1 223 ? -11.386 -11.584 -63.183  1    40.009  ? 223  LEU B CD2   1 ? 
ATOM   6553  N  N     . LEU B 1 224 ? -6.3    -11.475 -65.385  1    47.289  ? 224  LEU B N     1 ? 
ATOM   6554  C  CA    . LEU B 1 224 ? -5.051  -10.779 -65.624  1    45.731  ? 224  LEU B CA    1 ? 
ATOM   6555  C  C     . LEU B 1 224 ? -5.331  -9.473  -66.372  1    45.241  ? 224  LEU B C     1 ? 
ATOM   6556  O  O     . LEU B 1 224 ? -6.242  -9.413  -67.193  1    40.532  ? 224  LEU B O     1 ? 
ATOM   6557  C  CB    . LEU B 1 224 ? -4.16   -11.739 -66.413  1    48.549  ? 224  LEU B CB    1 ? 
ATOM   6558  C  CG    . LEU B 1 224 ? -2.71   -11.285 -66.614  1    60.33   ? 224  LEU B CG    1 ? 
ATOM   6559  C  CD1   . LEU B 1 224 ? -1.779  -12.485 -66.576  1    64.544  ? 224  LEU B CD1   1 ? 
ATOM   6560  C  CD2   . LEU B 1 224 ? -2.54   -10.496 -67.915  1    64.495  ? 224  LEU B CD2   1 ? 
ATOM   6561  N  N     . ARG B 1 225 ? -4.528  -8.436  -66.086  1    45.421  ? 225  ARG B N     1 ? 
ATOM   6562  C  CA    . ARG B 1 225 ? -4.531  -7.196  -66.859  1    50.891  ? 225  ARG B CA    1 ? 
ATOM   6563  C  C     . ARG B 1 225 ? -3.201  -6.471  -66.659  1    51.631  ? 225  ARG B C     1 ? 
ATOM   6564  O  O     . ARG B 1 225 ? -2.629  -6.536  -65.579  1    59.938  ? 225  ARG B O     1 ? 
ATOM   6565  C  CB    . ARG B 1 225 ? -5.708  -6.302  -66.458  1    43.943  ? 225  ARG B CB    1 ? 
ATOM   6566  C  CG    . ARG B 1 225 ? -6.039  -5.233  -67.489  1    58.16   ? 225  ARG B CG    1 ? 
ATOM   6567  C  CD    . ARG B 1 225 ? -7.195  -4.33   -67.083  1    59.093  ? 225  ARG B CD    1 ? 
ATOM   6568  N  NE    . ARG B 1 225 ? -6.992  -3.561  -65.848  1    74.481  ? 225  ARG B NE    1 ? 
ATOM   6569  C  CZ    . ARG B 1 225 ? -6.033  -2.666  -65.61   1    76.15   ? 225  ARG B CZ    1 ? 
ATOM   6570  N  NH1   . ARG B 1 225 ? -6.077  -1.919  -64.521  1    64.76   ? 225  ARG B NH1   1 ? 
ATOM   6571  N  NH2   . ARG B 1 225 ? -5.057  -2.484  -66.482  1    88.017  ? 225  ARG B NH2   1 ? 
ATOM   6572  N  N     . GLU B 1 226 ? -2.698  -5.792  -67.695  1    52.74   ? 226  GLU B N     1 ? 
ATOM   6573  C  CA    . GLU B 1 226 ? -1.481  -5      -67.544  1    65.239  ? 226  GLU B CA    1 ? 
ATOM   6574  C  C     . GLU B 1 226 ? -1.704  -3.978  -66.433  1    65.589  ? 226  GLU B C     1 ? 
ATOM   6575  O  O     . GLU B 1 226 ? -2.821  -3.494  -66.275  1    62.214  ? 226  GLU B O     1 ? 
ATOM   6576  C  CB    . GLU B 1 226 ? -1.08   -4.107  -68.723  1    62.857  ? 226  GLU B CB    1 ? 
ATOM   6577  C  CG    . GLU B 1 226 ? -1.702  -4.477  -70.064  1    67.349  ? 226  GLU B CG    1 ? 
ATOM   6578  C  CD    . GLU B 1 226 ? -3.121  -3.988  -70.268  1    65.098  ? 226  GLU B CD    1 ? 
ATOM   6579  O  OE1   . GLU B 1 226 ? -3.989  -4.832  -69.995  1    61.687  ? 226  GLU B OE1   1 ? 
ATOM   6580  O  OE2   . GLU B 1 226 ? -3.361  -2.838  -70.709  1    64.332  ? 226  GLU B OE2   1 ? 
ATOM   6581  N  N     . GLU B 1 227 ? -0.635  -3.631  -65.702  1    68.44   ? 227  GLU B N     1 ? 
ATOM   6582  C  CA    . GLU B 1 227 ? -0.73   -2.6    -64.676  1    80.647  ? 227  GLU B CA    1 ? 
ATOM   6583  C  C     . GLU B 1 227 ? -0.789  -1.218  -65.333  1    86.46   ? 227  GLU B C     1 ? 
ATOM   6584  O  O     . GLU B 1 227 ? -1.841  -0.579  -65.339  1    81.307  ? 227  GLU B O     1 ? 
ATOM   6585  C  CB    . GLU B 1 227 ? 0.342   -2.745  -63.595  1    83.928  ? 227  GLU B CB    1 ? 
ATOM   6586  C  CG    . GLU B 1 227 ? 0.114   -1.821  -62.398  1    94.628  ? 227  GLU B CG    1 ? 
ATOM   6587  C  CD    . GLU B 1 227 ? 1.073   -1.957  -61.224  1    105.452 ? 227  GLU B CD    1 ? 
ATOM   6588  O  OE1   . GLU B 1 227 ? 2.112   -2.641  -61.373  1    103.936 ? 227  GLU B OE1   1 ? 
ATOM   6589  O  OE2   . GLU B 1 227 ? 0.769   -1.391  -60.146  1    103.77  ? 227  GLU B OE2   1 ? 
ATOM   6590  N  N     . VAL B 1 228 ? 0.35    -0.758  -65.866  1    98.906  ? 228  VAL B N     1 ? 
ATOM   6591  C  CA    . VAL B 1 228 ? 0.385   0.455   -66.668  1    108.21  ? 228  VAL B CA    1 ? 
ATOM   6592  C  C     . VAL B 1 228 ? -0.302  0.116   -67.986  1    116.696 ? 228  VAL B C     1 ? 
ATOM   6593  O  O     . VAL B 1 228 ? -0.036  -0.942  -68.552  1    125.137 ? 228  VAL B O     1 ? 
ATOM   6594  C  CB    . VAL B 1 228 ? 1.815   1.004   -66.884  1    107.581 ? 228  VAL B CB    1 ? 
ATOM   6595  C  CG1   . VAL B 1 228 ? 1.873   2.143   -67.901  1    99.353  ? 228  VAL B CG1   1 ? 
ATOM   6596  C  CG2   . VAL B 1 228 ? 2.473   1.441   -65.578  1    102.255 ? 228  VAL B CG2   1 ? 
ATOM   6597  N  N     . ARG B 1 229 ? -1.195  1.007   -68.44   1    119.472 ? 229  ARG B N     1 ? 
ATOM   6598  C  CA    . ARG B 1 229 ? -1.984  0.809   -69.649  1    127.286 ? 229  ARG B CA    1 ? 
ATOM   6599  C  C     . ARG B 1 229 ? -1.1    0.882   -70.897  1    133.106 ? 229  ARG B C     1 ? 
ATOM   6600  O  O     . ARG B 1 229 ? -1.198  1.832   -71.673  1    138.127 ? 229  ARG B O     1 ? 
ATOM   6601  C  CB    . ARG B 1 229 ? -3.155  1.8     -69.678  1    124.152 ? 229  ARG B CB    1 ? 
ATOM   6602  C  CG    . ARG B 1 229 ? -4.521  1.308   -69.215  1    121.596 ? 229  ARG B CG    1 ? 
ATOM   6603  C  CD    . ARG B 1 229 ? -4.61   0.556   -67.886  1    108.654 ? 229  ARG B CD    1 ? 
ATOM   6604  N  NE    . ARG B 1 229 ? -6.005  0.276   -67.515  1    106.3   ? 229  ARG B NE    1 ? 
ATOM   6605  C  CZ    . ARG B 1 229 ? -6.904  -0.452  -68.19   1    98.752  ? 229  ARG B CZ    1 ? 
ATOM   6606  N  NH1   . ARG B 1 229 ? -6.575  -1.08   -69.305  1    101.712 ? 229  ARG B NH1   1 ? 
ATOM   6607  N  NH2   . ARG B 1 229 ? -8.14   -0.564  -67.737  1    86.167  ? 229  ARG B NH2   1 ? 
ATOM   6608  N  N     . PHE B 1 230 ? -0.258  -0.149  -71.076  1    131.189 ? 230  PHE B N     1 ? 
ATOM   6609  C  CA    . PHE B 1 230 ? 0.658   -0.323  -72.199  1    111.568 ? 230  PHE B CA    1 ? 
ATOM   6610  C  C     . PHE B 1 230 ? 1.253   1.028   -72.632  1    108.644 ? 230  PHE B C     1 ? 
ATOM   6611  O  O     . PHE B 1 230 ? 2.47    1.052   -72.936  1    98.001  ? 230  PHE B O     1 ? 
ATOM   6612  C  CB    . PHE B 1 230 ? 0.014   -1.136  -73.33   1    96.053  ? 230  PHE B CB    1 ? 
ATOM   6613  C  CG    . PHE B 1 230 ? -0.044  -2.642  -73.098  1    82.315  ? 230  PHE B CG    1 ? 
ATOM   6614  C  CD1   . PHE B 1 230 ? 0.989   -3.306  -72.437  1    69.024  ? 230  PHE B CD1   1 ? 
ATOM   6615  C  CD2   . PHE B 1 230 ? -1.129  -3.392  -73.551  1    75.374  ? 230  PHE B CD2   1 ? 
ATOM   6616  C  CE1   . PHE B 1 230 ? 0.933   -4.677  -72.232  1    68.036  ? 230  PHE B CE1   1 ? 
ATOM   6617  C  CE2   . PHE B 1 230 ? -1.18   -4.766  -73.344  1    68.972  ? 230  PHE B CE2   1 ? 
ATOM   6618  C  CZ    . PHE B 1 230 ? -0.15   -5.406  -72.68   1    66.295  ? 230  PHE B CZ    1 ? 
ATOM   6619  N  N     . THR B 1 244 ? 7.377   -5.082  -68.208  1    95.046  ? 244  THR B N     1 ? 
ATOM   6620  C  CA    . THR B 1 244 ? 5.918   -4.848  -68.084  1    92.487  ? 244  THR B CA    1 ? 
ATOM   6621  C  C     . THR B 1 244 ? 5.38    -5.7    -66.937  1    80.626  ? 244  THR B C     1 ? 
ATOM   6622  O  O     . THR B 1 244 ? 5.755   -6.863  -66.793  1    86.941  ? 244  THR B O     1 ? 
ATOM   6623  C  CB    . THR B 1 244 ? 5.229   -5.161  -69.414  1    88.82   ? 244  THR B CB    1 ? 
ATOM   6624  O  OG1   . THR B 1 244 ? 6.01    -4.486  -70.394  1    97.505  ? 244  THR B OG1   1 ? 
ATOM   6625  C  CG2   . THR B 1 244 ? 3.801   -4.652  -69.489  1    79.735  ? 244  THR B CG2   1 ? 
ATOM   6626  N  N     . THR B 1 245 ? 4.504   -5.1    -66.122  1    72.752  ? 245  THR B N     1 ? 
ATOM   6627  C  CA    . THR B 1 245 ? 3.902   -5.789  -64.989  1    62.722  ? 245  THR B CA    1 ? 
ATOM   6628  C  C     . THR B 1 245 ? 2.395   -5.946  -65.211  1    57.834  ? 245  THR B C     1 ? 
ATOM   6629  O  O     . THR B 1 245 ? 1.783   -5.208  -65.995  1    51.626  ? 245  THR B O     1 ? 
ATOM   6630  C  CB    . THR B 1 245 ? 4.205   -5.062  -63.678  1    62.05   ? 245  THR B CB    1 ? 
ATOM   6631  O  OG1   . THR B 1 245 ? 3.392   -3.894  -63.733  1    62.661  ? 245  THR B OG1   1 ? 
ATOM   6632  C  CG2   . THR B 1 245 ? 5.676   -4.727  -63.485  1    65.206  ? 245  THR B CG2   1 ? 
ATOM   6633  N  N     . PHE B 1 246 ? 1.811   -6.91   -64.484  1    53.978  ? 246  PHE B N     1 ? 
ATOM   6634  C  CA    . PHE B 1 246 ? 0.413   -7.266  -64.632  1    55.055  ? 246  PHE B CA    1 ? 
ATOM   6635  C  C     . PHE B 1 246 ? -0.207  -7.552  -63.269  1    53.587  ? 246  PHE B C     1 ? 
ATOM   6636  O  O     . PHE B 1 246 ? 0.379   -8.26   -62.455  1    51.281  ? 246  PHE B O     1 ? 
ATOM   6637  C  CB    . PHE B 1 246 ? 0.439   -8.516  -65.514  1    57.352  ? 246  PHE B CB    1 ? 
ATOM   6638  C  CG    . PHE B 1 246 ? 0.903   -8.261  -66.942  1    70.168  ? 246  PHE B CG    1 ? 
ATOM   6639  C  CD1   . PHE B 1 246 ? 2.258   -8.207  -67.261  1    72.351  ? 246  PHE B CD1   1 ? 
ATOM   6640  C  CD2   . PHE B 1 246 ? -0.023  -8.08   -67.968  1    74.7    ? 246  PHE B CD2   1 ? 
ATOM   6641  C  CE1   . PHE B 1 246 ? 2.671   -7.966  -68.566  1    77.146  ? 246  PHE B CE1   1 ? 
ATOM   6642  C  CE2   . PHE B 1 246 ? 0.394   -7.839  -69.268  1    70.757  ? 246  PHE B CE2   1 ? 
ATOM   6643  C  CZ    . PHE B 1 246 ? 1.739   -7.784  -69.565  1    68.24   ? 246  PHE B CZ    1 ? 
ATOM   6644  N  N     . HIS B 1 247 ? -1.403  -7      -63.034  1    53.785  ? 247  HIS B N     1 ? 
ATOM   6645  C  CA    . HIS B 1 247 ? -2.287  -7.505  -61.993  1    48.946  ? 247  HIS B CA    1 ? 
ATOM   6646  C  C     . HIS B 1 247 ? -2.61   -8.964  -62.291  1    50.743  ? 247  HIS B C     1 ? 
ATOM   6647  O  O     . HIS B 1 247 ? -2.91   -9.319  -63.431  1    46.472  ? 247  HIS B O     1 ? 
ATOM   6648  C  CB    . HIS B 1 247 ? -3.6    -6.718  -61.927  1    47.362  ? 247  HIS B CB    1 ? 
ATOM   6649  C  CG    . HIS B 1 247 ? -3.377  -5.301  -61.549  1    57.622  ? 247  HIS B CG    1 ? 
ATOM   6650  N  ND1   . HIS B 1 247 ? -2.935  -4.956  -60.289  1    62.528  ? 247  HIS B ND1   1 ? 
ATOM   6651  C  CD2   . HIS B 1 247 ? -3.453  -4.164  -62.253  1    60.163  ? 247  HIS B CD2   1 ? 
ATOM   6652  C  CE1   . HIS B 1 247 ? -2.769  -3.64   -60.24   1    65.372  ? 247  HIS B CE1   1 ? 
ATOM   6653  N  NE2   . HIS B 1 247 ? -3.092  -3.137  -61.417  1    68.076  ? 247  HIS B NE2   1 ? 
ATOM   6654  N  N     . LEU B 1 248 ? -2.523  -9.803  -61.255  1    49.614  ? 248  LEU B N     1 ? 
ATOM   6655  C  CA    . LEU B 1 248 ? -2.838  -11.214 -61.392  1    47.648  ? 248  LEU B CA    1 ? 
ATOM   6656  C  C     . LEU B 1 248 ? -3.652  -11.615 -60.183  1    48.694  ? 248  LEU B C     1 ? 
ATOM   6657  O  O     . LEU B 1 248 ? -3.194  -11.451 -59.051  1    52.535  ? 248  LEU B O     1 ? 
ATOM   6658  C  CB    . LEU B 1 248 ? -1.605  -12.096 -61.542  1    55.101  ? 248  LEU B CB    1 ? 
ATOM   6659  C  CG    . LEU B 1 248 ? -1.876  -13.601 -61.629  1    63.737  ? 248  LEU B CG    1 ? 
ATOM   6660  C  CD1   . LEU B 1 248 ? -2.477  -13.978 -62.973  1    66.187  ? 248  LEU B CD1   1 ? 
ATOM   6661  C  CD2   . LEU B 1 248 ? -0.605  -14.398 -61.344  1    67.271  ? 248  LEU B CD2   1 ? 
ATOM   6662  N  N     . LEU B 1 249 ? -4.864  -12.103 -60.455  1    45.024  ? 249  LEU B N     1 ? 
ATOM   6663  C  CA    . LEU B 1 249 ? -5.791  -12.491 -59.414  1    45.405  ? 249  LEU B CA    1 ? 
ATOM   6664  C  C     . LEU B 1 249 ? -6.083  -13.974 -59.569  1    47.587  ? 249  LEU B C     1 ? 
ATOM   6665  O  O     . LEU B 1 249 ? -6.606  -14.375 -60.605  1    44.911  ? 249  LEU B O     1 ? 
ATOM   6666  C  CB    . LEU B 1 249 ? -7.078  -11.673 -59.532  1    42.483  ? 249  LEU B CB    1 ? 
ATOM   6667  C  CG    . LEU B 1 249 ? -8.231  -12.137 -58.642  1    43.329  ? 249  LEU B CG    1 ? 
ATOM   6668  C  CD1   . LEU B 1 249 ? -7.791  -12.025 -57.188  1    47.515  ? 249  LEU B CD1   1 ? 
ATOM   6669  C  CD2   . LEU B 1 249 ? -9.476  -11.31  -58.871  1    44.812  ? 249  LEU B CD2   1 ? 
ATOM   6670  N  N     . HIS B 1 250 ? -5.785  -14.761 -58.526  1    41.621  ? 250  HIS B N     1 ? 
ATOM   6671  C  CA    . HIS B 1 250 ? -6.037  -16.188 -58.562  1    42.456  ? 250  HIS B CA    1 ? 
ATOM   6672  C  C     . HIS B 1 250 ? -7.297  -16.498 -57.775  1    44.902  ? 250  HIS B C     1 ? 
ATOM   6673  O  O     . HIS B 1 250 ? -7.32   -16.342 -56.555  1    45.698  ? 250  HIS B O     1 ? 
ATOM   6674  C  CB    . HIS B 1 250 ? -4.89   -16.976 -57.918  1    54.659  ? 250  HIS B CB    1 ? 
ATOM   6675  C  CG    . HIS B 1 250 ? -3.666  -17.035 -58.75   1    62.19   ? 250  HIS B CG    1 ? 
ATOM   6676  N  ND1   . HIS B 1 250 ? -3.672  -17.533 -60.035  1    64.614  ? 250  HIS B ND1   1 ? 
ATOM   6677  C  CD2   . HIS B 1 250 ? -2.403  -16.696 -58.479  1    65.324  ? 250  HIS B CD2   1 ? 
ATOM   6678  C  CE1   . HIS B 1 250 ? -2.446  -17.46  -60.531  1    67.1    ? 250  HIS B CE1   1 ? 
ATOM   6679  N  NE2   . HIS B 1 250 ? -1.661  -16.957 -59.6    1    68.146  ? 250  HIS B NE2   1 ? 
ATOM   6680  N  N     . LEU B 1 251 ? -8.311  -17.011 -58.474  1    43.206  ? 251  LEU B N     1 ? 
ATOM   6681  C  CA    . LEU B 1 251 ? -9.591  -17.281 -57.852  1    41.192  ? 251  LEU B CA    1 ? 
ATOM   6682  C  C     . LEU B 1 251 ? -9.485  -18.493 -56.937  1    43.611  ? 251  LEU B C     1 ? 
ATOM   6683  O  O     . LEU B 1 251 ? -10.37  -18.716 -56.111  1    44.073  ? 251  LEU B O     1 ? 
ATOM   6684  C  CB    . LEU B 1 251 ? -10.676 -17.476 -58.904  1    40.565  ? 251  LEU B CB    1 ? 
ATOM   6685  C  CG    . LEU B 1 251 ? -11.049 -16.242 -59.734  1    43.997  ? 251  LEU B CG    1 ? 
ATOM   6686  C  CD1   . LEU B 1 251 ? -12.382 -16.545 -60.391  1    37.664  ? 251  LEU B CD1   1 ? 
ATOM   6687  C  CD2   . LEU B 1 251 ? -11.156 -14.951 -58.925  1    39.392  ? 251  LEU B CD2   1 ? 
ATOM   6688  N  N     . SER B 1 252 ? -8.433  -19.304 -57.117  1    44.918  ? 252  SER B N     1 ? 
ATOM   6689  C  CA    . SER B 1 252 ? -8.256  -20.448 -56.229  1    44.892  ? 252  SER B CA    1 ? 
ATOM   6690  C  C     . SER B 1 252 ? -7.936  -19.97  -54.811  1    37.307  ? 252  SER B C     1 ? 
ATOM   6691  O  O     . SER B 1 252 ? -8.456  -20.523 -53.845  1    44.33   ? 252  SER B O     1 ? 
ATOM   6692  C  CB    . SER B 1 252 ? -7.225  -21.432 -56.725  1    41.36   ? 252  SER B CB    1 ? 
ATOM   6693  O  OG    . SER B 1 252 ? -5.982  -20.783 -56.932  1    46.844  ? 252  SER B OG    1 ? 
ATOM   6694  N  N     . LEU B 1 253 ? -7.08   -18.953 -54.704  1    38.366  ? 253  LEU B N     1 ? 
ATOM   6695  C  CA    . LEU B 1 253 ? -6.813  -18.302 -53.423  1    49.397  ? 253  LEU B CA    1 ? 
ATOM   6696  C  C     . LEU B 1 253 ? -8.068  -17.595 -52.911  1    48.839  ? 253  LEU B C     1 ? 
ATOM   6697  O  O     . LEU B 1 253 ? -8.365  -17.655 -51.718  1    52.495  ? 253  LEU B O     1 ? 
ATOM   6698  C  CB    . LEU B 1 253 ? -5.603  -17.365 -53.477  1    58.916  ? 253  LEU B CB    1 ? 
ATOM   6699  C  CG    . LEU B 1 253 ? -4.238  -18.027 -53.723  1    71.754  ? 253  LEU B CG    1 ? 
ATOM   6700  C  CD1   . LEU B 1 253 ? -3.116  -17.007 -53.912  1    72.114  ? 253  LEU B CD1   1 ? 
ATOM   6701  C  CD2   . LEU B 1 253 ? -3.863  -19.031 -52.637  1    70.845  ? 253  LEU B CD2   1 ? 
ATOM   6702  N  N     . MET B 1 254 ? -8.816  -16.949 -53.82   1    43.164  ? 254  MET B N     1 ? 
ATOM   6703  C  CA    . MET B 1 254 ? -9.975  -16.17  -53.421  1    40.938  ? 254  MET B CA    1 ? 
ATOM   6704  C  C     . MET B 1 254 ? -11.049 -17.103 -52.875  1    42.71   ? 254  MET B C     1 ? 
ATOM   6705  O  O     . MET B 1 254 ? -11.729 -16.778 -51.902  1    40.65   ? 254  MET B O     1 ? 
ATOM   6706  C  CB    . MET B 1 254 ? -10.538 -15.347 -54.578  1    45.885  ? 254  MET B CB    1 ? 
ATOM   6707  C  CG    . MET B 1 254 ? -11.869 -14.742 -54.232  1    49.549  ? 254  MET B CG    1 ? 
ATOM   6708  S  SD    . MET B 1 254 ? -12.236 -13.409 -55.386  1    48.722  ? 254  MET B SD    1 ? 
ATOM   6709  C  CE    . MET B 1 254 ? -13.802 -13.019 -54.589  1    42.218  ? 254  MET B CE    1 ? 
ATOM   6710  N  N     . ARG B 1 255 ? -11.16  -18.289 -53.487  1    38.823  ? 255  ARG B N     1 ? 
ATOM   6711  C  CA    . ARG B 1 255 ? -12.056 -19.323 -52.997  1    38.092  ? 255  ARG B CA    1 ? 
ATOM   6712  C  C     . ARG B 1 255 ? -11.641 -19.73  -51.58   1    37.515  ? 255  ARG B C     1 ? 
ATOM   6713  O  O     . ARG B 1 255 ? -12.503 -20.011 -50.737  1    40.574  ? 255  ARG B O     1 ? 
ATOM   6714  C  CB    . ARG B 1 255 ? -12.101 -20.497 -53.985  1    42.906  ? 255  ARG B CB    1 ? 
ATOM   6715  C  CG    . ARG B 1 255 ? -12.673 -20.27  -55.384  1    41.92   ? 255  ARG B CG    1 ? 
ATOM   6716  C  CD    . ARG B 1 255 ? -12.131 -21.307 -56.394  1    43.775  ? 255  ARG B CD    1 ? 
ATOM   6717  N  NE    . ARG B 1 255 ? -12.246 -22.712 -55.966  1    40.625  ? 255  ARG B NE    1 ? 
ATOM   6718  C  CZ    . ARG B 1 255 ? -13.372 -23.42  -55.822  1    44.16   ? 255  ARG B CZ    1 ? 
ATOM   6719  N  NH1   . ARG B 1 255 ? -14.534 -22.942 -56.243  1    42.054  ? 255  ARG B NH1   1 ? 
ATOM   6720  N  NH2   . ARG B 1 255 ? -13.33  -24.636 -55.286  1    38.725  ? 255  ARG B NH2   1 ? 
ATOM   6721  N  N     . GLU B 1 256 ? -10.327 -19.712 -51.32   1    38.045  ? 256  GLU B N     1 ? 
ATOM   6722  C  CA    . GLU B 1 256 ? -9.795  -20.138 -50.022  1    48.935  ? 256  GLU B CA    1 ? 
ATOM   6723  C  C     . GLU B 1 256 ? -10.031 -19.078 -48.944  1    49.323  ? 256  GLU B C     1 ? 
ATOM   6724  O  O     . GLU B 1 256 ? -10.474 -19.41  -47.843  1    57.893  ? 256  GLU B O     1 ? 
ATOM   6725  C  CB    . GLU B 1 256 ? -8.33   -20.565 -50.058  1    51.387  ? 256  GLU B CB    1 ? 
ATOM   6726  C  CG    . GLU B 1 256 ? -8.092  -21.944 -50.67   1    70.184  ? 256  GLU B CG    1 ? 
ATOM   6727  C  CD    . GLU B 1 256 ? -6.619  -22.171 -50.984  1    86.391  ? 256  GLU B CD    1 ? 
ATOM   6728  O  OE1   . GLU B 1 256 ? -6.287  -22.554 -52.135  1    93.615  ? 256  GLU B OE1   1 ? 
ATOM   6729  O  OE2   . GLU B 1 256 ? -5.796  -21.938 -50.067  1    91.948  ? 256  GLU B OE2   1 ? 
ATOM   6730  N  N     . TYR B 1 257 ? -9.783  -17.804 -49.284  1    46.385  ? 257  TYR B N     1 ? 
ATOM   6731  C  CA    . TYR B 1 257 ? -10.11  -16.686 -48.407  1    45.743  ? 257  TYR B CA    1 ? 
ATOM   6732  C  C     . TYR B 1 257 ? -11.598 -16.692 -48.068  1    45.032  ? 257  TYR B C     1 ? 
ATOM   6733  O  O     . TYR B 1 257 ? -11.996 -16.493 -46.913  1    46.224  ? 257  TYR B O     1 ? 
ATOM   6734  C  CB    . TYR B 1 257 ? -9.605  -15.349 -48.956  1    48.558  ? 257  TYR B CB    1 ? 
ATOM   6735  C  CG    . TYR B 1 257 ? -8.119  -15.178 -48.686  1    62.824  ? 257  TYR B CG    1 ? 
ATOM   6736  C  CD1   . TYR B 1 257 ? -7.175  -15.746 -49.531  1    70.916  ? 257  TYR B CD1   1 ? 
ATOM   6737  C  CD2   . TYR B 1 257 ? -7.662  -14.485 -47.569  1    75.516  ? 257  TYR B CD2   1 ? 
ATOM   6738  C  CE1   . TYR B 1 257 ? -5.818  -15.622 -49.29   1    83.848  ? 257  TYR B CE1   1 ? 
ATOM   6739  C  CE2   . TYR B 1 257 ? -6.305  -14.354 -47.315  1    87.903  ? 257  TYR B CE2   1 ? 
ATOM   6740  C  CZ    . TYR B 1 257 ? -5.381  -14.924 -48.178  1    93.189  ? 257  TYR B CZ    1 ? 
ATOM   6741  O  OH    . TYR B 1 257 ? -4.035  -14.819 -47.962  1    101.499 ? 257  TYR B OH    1 ? 
ATOM   6742  N  N     . ILE B 1 258 ? -12.425 -16.967 -49.07   1    38.896  ? 258  ILE B N     1 ? 
ATOM   6743  C  CA    . ILE B 1 258 ? -13.85  -16.988 -48.812  1    38.584  ? 258  ILE B CA    1 ? 
ATOM   6744  C  C     . ILE B 1 258 ? -14.187 -18.126 -47.856  1    38.303  ? 258  ILE B C     1 ? 
ATOM   6745  O  O     . ILE B 1 258 ? -15.025 -17.962 -46.974  1    41.443  ? 258  ILE B O     1 ? 
ATOM   6746  C  CB    . ILE B 1 258 ? -14.657 -17.028 -50.119  1    38.796  ? 258  ILE B CB    1 ? 
ATOM   6747  C  CG1   . ILE B 1 258 ? -14.484 -15.706 -50.889  1    43.305  ? 258  ILE B CG1   1 ? 
ATOM   6748  C  CG2   . ILE B 1 258 ? -16.125 -17.356 -49.832  1    36.62   ? 258  ILE B CG2   1 ? 
ATOM   6749  C  CD1   . ILE B 1 258 ? -14.988 -15.75  -52.322  1    38.596  ? 258  ILE B CD1   1 ? 
ATOM   6750  N  N     . ASP B 1 259 ? -13.53  -19.27  -48.038  1    41.747  ? 259  ASP B N     1 ? 
ATOM   6751  C  CA    . ASP B 1 259 ? -13.789 -20.455 -47.222  1    46.72   ? 259  ASP B CA    1 ? 
ATOM   6752  C  C     . ASP B 1 259 ? -13.508 -20.162 -45.745  1    46.624  ? 259  ASP B C     1 ? 
ATOM   6753  O  O     . ASP B 1 259 ? -14.353 -20.402 -44.875  1    42.517  ? 259  ASP B O     1 ? 
ATOM   6754  C  CB    . ASP B 1 259 ? -12.892 -21.599 -47.679  1    49.091  ? 259  ASP B CB    1 ? 
ATOM   6755  C  CG    . ASP B 1 259 ? -13.367 -23.012 -47.371  1    43.408  ? 259  ASP B CG    1 ? 
ATOM   6756  O  OD1   . ASP B 1 259 ? -14.38  -23.177 -46.663  1    41.368  ? 259  ASP B OD1   1 ? 
ATOM   6757  O  OD2   . ASP B 1 259 ? -12.742 -23.937 -47.91   1    55.711  ? 259  ASP B OD2   1 ? 
ATOM   6758  N  N     . TYR B 1 260 ? -12.311 -19.62  -45.495  1    47.97   ? 260  TYR B N     1 ? 
ATOM   6759  C  CA    . TYR B 1 260 ? -11.839 -19.255 -44.171  1    59.148  ? 260  TYR B CA    1 ? 
ATOM   6760  C  C     . TYR B 1 260 ? -12.798 -18.237 -43.546  1    57.726  ? 260  TYR B C     1 ? 
ATOM   6761  O  O     . TYR B 1 260 ? -13.185 -18.378 -42.389  1    50.765  ? 260  TYR B O     1 ? 
ATOM   6762  C  CB    . TYR B 1 260 ? -10.352 -18.914 -44.36   1    72.992  ? 260  TYR B CB    1 ? 
ATOM   6763  C  CG    . TYR B 1 260 ? -9.479  -18.672 -43.132  1    95.712  ? 260  TYR B CG    1 ? 
ATOM   6764  C  CD1   . TYR B 1 260 ? -9.938  -18.919 -41.838  1    100.695 ? 260  TYR B CD1   1 ? 
ATOM   6765  C  CD2   . TYR B 1 260 ? -8.168  -18.218 -43.274  1    111.417 ? 260  TYR B CD2   1 ? 
ATOM   6766  C  CE1   . TYR B 1 260 ? -9.135  -18.695 -40.729  1    103.862 ? 260  TYR B CE1   1 ? 
ATOM   6767  C  CE2   . TYR B 1 260 ? -7.353  -17.997 -42.174  1    114.066 ? 260  TYR B CE2   1 ? 
ATOM   6768  C  CZ    . TYR B 1 260 ? -7.838  -18.237 -40.899  1    109.822 ? 260  TYR B CZ    1 ? 
ATOM   6769  O  OH    . TYR B 1 260 ? -7.04   -18.024 -39.813  1    102.474 ? 260  TYR B OH    1 ? 
ATOM   6770  N  N     . GLU B 1 261 ? -13.233 -17.239 -44.324  1    58.71   ? 261  GLU B N     1 ? 
ATOM   6771  C  CA    . GLU B 1 261 ? -14.146 -16.23  -43.805  1    53.113  ? 261  GLU B CA    1 ? 
ATOM   6772  C  C     . GLU B 1 261 ? -15.452 -16.87  -43.337  1    55.823  ? 261  GLU B C     1 ? 
ATOM   6773  O  O     . GLU B 1 261 ? -16.012 -16.449 -42.329  1    61.682  ? 261  GLU B O     1 ? 
ATOM   6774  C  CB    . GLU B 1 261 ? -14.396 -15.095 -44.798  1    59.149  ? 261  GLU B CB    1 ? 
ATOM   6775  C  CG    . GLU B 1 261 ? -15.4   -14.065 -44.288  1    60.324  ? 261  GLU B CG    1 ? 
ATOM   6776  C  CD    . GLU B 1 261 ? -15.727 -12.934 -45.244  1    60.652  ? 261  GLU B CD    1 ? 
ATOM   6777  O  OE1   . GLU B 1 261 ? -15.07  -12.873 -46.299  1    60.683  ? 261  GLU B OE1   1 ? 
ATOM   6778  O  OE2   . GLU B 1 261 ? -16.637 -12.125 -44.932  1    58.181  ? 261  GLU B OE2   1 ? 
ATOM   6779  N  N     . PHE B 1 262 ? -15.943 -17.879 -44.064  1    49.313  ? 262  PHE B N     1 ? 
ATOM   6780  C  CA    . PHE B 1 262 ? -17.282 -18.386 -43.803  1    46.354  ? 262  PHE B CA    1 ? 
ATOM   6781  C  C     . PHE B 1 262 ? -17.237 -19.646 -42.937  1    45.001  ? 262  PHE B C     1 ? 
ATOM   6782  O  O     . PHE B 1 262 ? -18.287 -20.233 -42.673  1    43.228  ? 262  PHE B O     1 ? 
ATOM   6783  C  CB    . PHE B 1 262 ? -18.091 -18.528 -45.096  1    45.67   ? 262  PHE B CB    1 ? 
ATOM   6784  C  CG    . PHE B 1 262 ? -18.606 -17.179 -45.586  1    51.246  ? 262  PHE B CG    1 ? 
ATOM   6785  C  CD1   . PHE B 1 262 ? -17.791 -16.355 -46.356  1    47.113  ? 262  PHE B CD1   1 ? 
ATOM   6786  C  CD2   . PHE B 1 262 ? -19.882 -16.732 -45.236  1    42.12   ? 262  PHE B CD2   1 ? 
ATOM   6787  C  CE1   . PHE B 1 262 ? -18.25  -15.112 -46.767  1    56.101  ? 262  PHE B CE1   1 ? 
ATOM   6788  C  CE2   . PHE B 1 262 ? -20.337 -15.498 -45.656  1    50.773  ? 262  PHE B CE2   1 ? 
ATOM   6789  C  CZ    . PHE B 1 262 ? -19.518 -14.684 -46.413  1    47.427  ? 262  PHE B CZ    1 ? 
ATOM   6790  N  N     . SER B 1 263 ? -16.027 -20.005 -42.477  1    51.503  ? 263  SER B N     1 ? 
ATOM   6791  C  CA    . SER B 1 263 ? -15.729 -21.246 -41.763  1    54.003  ? 263  SER B CA    1 ? 
ATOM   6792  C  C     . SER B 1 263 ? -16.59  -21.428 -40.516  1    48.389  ? 263  SER B C     1 ? 
ATOM   6793  O  O     . SER B 1 263 ? -16.986 -22.552 -40.209  1    56.345  ? 263  SER B O     1 ? 
ATOM   6794  C  CB    . SER B 1 263 ? -14.279 -21.315 -41.406  1    58.266  ? 263  SER B CB    1 ? 
ATOM   6795  O  OG    . SER B 1 263 ? -13.531 -21.69  -42.548  1    69.207  ? 263  SER B OG    1 ? 
ATOM   6796  N  N     . VAL B 1 264 ? -16.912 -20.311 -39.849  1    46.845  ? 264  VAL B N     1 ? 
ATOM   6797  C  CA    . VAL B 1 264 ? -17.67  -20.269 -38.605  1    47.009  ? 264  VAL B CA    1 ? 
ATOM   6798  C  C     . VAL B 1 264 ? -19.008 -20.999 -38.754  1    52.491  ? 264  VAL B C     1 ? 
ATOM   6799  O  O     . VAL B 1 264 ? -19.557 -21.508 -37.775  1    55.688  ? 264  VAL B O     1 ? 
ATOM   6800  C  CB    . VAL B 1 264 ? -17.848 -18.843 -38.033  1    54.462  ? 264  VAL B CB    1 ? 
ATOM   6801  C  CG1   . VAL B 1 264 ? -16.513 -18.16  -37.769  1    58.568  ? 264  VAL B CG1   1 ? 
ATOM   6802  C  CG2   . VAL B 1 264 ? -18.732 -17.946 -38.901  1    53.047  ? 264  VAL B CG2   1 ? 
ATOM   6803  N  N     . LEU B 1 265 ? -19.53  -21.078 -39.981  1    42.435  ? 265  LEU B N     1 ? 
ATOM   6804  C  CA    . LEU B 1 265 ? -20.822 -21.72  -40.195  1    43.447  ? 265  LEU B CA    1 ? 
ATOM   6805  C  C     . LEU B 1 265 ? -20.733 -23.24  -39.991  1    36.763  ? 265  LEU B C     1 ? 
ATOM   6806  O  O     . LEU B 1 265 ? -21.756 -23.902 -39.8    1    39.221  ? 265  LEU B O     1 ? 
ATOM   6807  C  CB    . LEU B 1 265 ? -21.359 -21.322 -41.578  1    48.627  ? 265  LEU B CB    1 ? 
ATOM   6808  C  CG    . LEU B 1 265 ? -21.893 -19.884 -41.711  1    43.842  ? 265  LEU B CG    1 ? 
ATOM   6809  C  CD1   . LEU B 1 265 ? -21.821 -19.35  -43.144  1    52.282  ? 265  LEU B CD1   1 ? 
ATOM   6810  C  CD2   . LEU B 1 265 ? -23.324 -19.829 -41.219  1    37.37   ? 265  LEU B CD2   1 ? 
ATOM   6811  N  N     . LYS B 1 266 ? -19.516 -23.8   -40.023  1    36.057  ? 266  LYS B N     1 ? 
ATOM   6812  C  CA    . LYS B 1 266 ? -19.311 -25.23  -39.771  1    47.416  ? 266  LYS B CA    1 ? 
ATOM   6813  C  C     . LYS B 1 266 ? -19.771 -25.62  -38.358  1    50.815  ? 266  LYS B C     1 ? 
ATOM   6814  O  O     . LYS B 1 266 ? -20.123 -26.774 -38.123  1    50.913  ? 266  LYS B O     1 ? 
ATOM   6815  C  CB    . LYS B 1 266 ? -17.88  -25.724 -40.038  1    49.519  ? 266  LYS B CB    1 ? 
ATOM   6816  C  CG    . LYS B 1 266 ? -17.382 -25.655 -41.482  1    54.323  ? 266  LYS B CG    1 ? 
ATOM   6817  C  CD    . LYS B 1 266 ? -16.372 -26.712 -41.93   1    63.127  ? 266  LYS B CD    1 ? 
ATOM   6818  C  CE    . LYS B 1 266 ? -14.941 -26.506 -41.529  1    63.593  ? 266  LYS B CE    1 ? 
ATOM   6819  N  NZ    . LYS B 1 266 ? -14.26  -25.577 -42.43   1    55.114  ? 266  LYS B NZ    1 ? 
ATOM   6820  N  N     . GLU B 1 267 ? -19.808 -24.644 -37.436  1    46.903  ? 267  GLU B N     1 ? 
ATOM   6821  C  CA    . GLU B 1 267 ? -20.247 -24.873 -36.069  1    52.634  ? 267  GLU B CA    1 ? 
ATOM   6822  C  C     . GLU B 1 267 ? -21.734 -24.585 -35.902  1    55.287  ? 267  GLU B C     1 ? 
ATOM   6823  O  O     . GLU B 1 267 ? -22.271 -24.769 -34.809  1    50.943  ? 267  GLU B O     1 ? 
ATOM   6824  C  CB    . GLU B 1 267 ? -19.603 -23.877 -35.107  1    60.494  ? 267  GLU B CB    1 ? 
ATOM   6825  C  CG    . GLU B 1 267 ? -18.081 -23.884 -35.171  1    71.221  ? 267  GLU B CG    1 ? 
ATOM   6826  C  CD    . GLU B 1 267 ? -17.448 -22.876 -34.232  1    79.329  ? 267  GLU B CD    1 ? 
ATOM   6827  O  OE1   . GLU B 1 267 ? -16.288 -22.491 -34.519  1    87.357  ? 267  GLU B OE1   1 ? 
ATOM   6828  O  OE2   . GLU B 1 267 ? -18.095 -22.501 -33.22   1    73.723  ? 267  GLU B OE2   1 ? 
ATOM   6829  N  N     . LYS B 1 268 ? -22.396 -24.119 -36.968  1    54.743  ? 268  LYS B N     1 ? 
ATOM   6830  C  CA    . LYS B 1 268 ? -23.683 -23.464 -36.774  1    54.219  ? 268  LYS B CA    1 ? 
ATOM   6831  C  C     . LYS B 1 268 ? -24.781 -24.152 -37.583  1    54.024  ? 268  LYS B C     1 ? 
ATOM   6832  O  O     . LYS B 1 268 ? -25.862 -24.386 -37.061  1    54.015  ? 268  LYS B O     1 ? 
ATOM   6833  C  CB    . LYS B 1 268 ? -23.561 -21.961 -37.076  1    63.949  ? 268  LYS B CB    1 ? 
ATOM   6834  C  CG    . LYS B 1 268 ? -22.467 -21.147 -36.37   1    72.695  ? 268  LYS B CG    1 ? 
ATOM   6835  C  CD    . LYS B 1 268 ? -22.804 -20.42  -35.069  1    79.169  ? 268  LYS B CD    1 ? 
ATOM   6836  C  CE    . LYS B 1 268 ? -22.949 -21.254 -33.84   1    86.561  ? 268  LYS B CE    1 ? 
ATOM   6837  N  NZ    . LYS B 1 268 ? -23.429 -20.458 -32.708  1    84.147  ? 268  LYS B NZ    1 ? 
ATOM   6838  N  N     . ILE B 1 269 ? -24.505 -24.454 -38.863  1    53.316  ? 269  ILE B N     1 ? 
ATOM   6839  C  CA    . ILE B 1 269 ? -25.497 -25.034 -39.763  1    57.419  ? 269  ILE B CA    1 ? 
ATOM   6840  C  C     . ILE B 1 269 ? -25.548 -26.554 -39.58   1    51.984  ? 269  ILE B C     1 ? 
ATOM   6841  O  O     . ILE B 1 269 ? -24.541 -27.168 -39.224  1    44.826  ? 269  ILE B O     1 ? 
ATOM   6842  C  CB    . ILE B 1 269 ? -25.233 -24.635 -41.236  1    59.448  ? 269  ILE B CB    1 ? 
ATOM   6843  C  CG1   . ILE B 1 269 ? -23.954 -25.275 -41.795  1    50.026  ? 269  ILE B CG1   1 ? 
ATOM   6844  C  CG2   . ILE B 1 269 ? -25.223 -23.11  -41.398  1    60.949  ? 269  ILE B CG2   1 ? 
ATOM   6845  C  CD1   . ILE B 1 269 ? -23.685 -25.007 -43.263  1    55.764  ? 269  ILE B CD1   1 ? 
ATOM   6846  N  N     . THR B 1 270 ? -26.72  -27.136 -39.876  1    43.268  ? 270  THR B N     1 ? 
ATOM   6847  C  CA    . THR B 1 270 ? -27.019 -28.538 -39.646  1    44.985  ? 270  THR B CA    1 ? 
ATOM   6848  C  C     . THR B 1 270 ? -27.086 -29.266 -40.989  1    44.857  ? 270  THR B C     1 ? 
ATOM   6849  O  O     . THR B 1 270 ? -27.52  -30.411 -41.059  1    43.084  ? 270  THR B O     1 ? 
ATOM   6850  C  CB    . THR B 1 270 ? -28.336 -28.666 -38.878  1    49.823  ? 270  THR B CB    1 ? 
ATOM   6851  O  OG1   . THR B 1 270 ? -29.359 -28.413 -39.836  1    59.125  ? 270  THR B OG1   1 ? 
ATOM   6852  C  CG2   . THR B 1 270 ? -28.441 -27.678 -37.728  1    49.3    ? 270  THR B CG2   1 ? 
ATOM   6853  N  N     . PHE B 1 271 ? -26.694 -28.571 -42.06   1    40.224  ? 271  PHE B N     1 ? 
ATOM   6854  C  CA    . PHE B 1 271 ? -26.478 -29.219 -43.335  1    42.746  ? 271  PHE B CA    1 ? 
ATOM   6855  C  C     . PHE B 1 271 ? -25.012 -29.038 -43.683  1    42.444  ? 271  PHE B C     1 ? 
ATOM   6856  O  O     . PHE B 1 271 ? -24.288 -28.295 -43.013  1    43.548  ? 271  PHE B O     1 ? 
ATOM   6857  C  CB    . PHE B 1 271 ? -27.428 -28.672 -44.404  1    49.785  ? 271  PHE B CB    1 ? 
ATOM   6858  C  CG    . PHE B 1 271 ? -27.416 -27.149 -44.473  1    47.617  ? 271  PHE B CG    1 ? 
ATOM   6859  C  CD1   . PHE B 1 271 ? -28.251 -26.39  -43.651  1    44.117  ? 271  PHE B CD1   1 ? 
ATOM   6860  C  CD2   . PHE B 1 271 ? -26.577 -26.48  -45.361  1    47.305  ? 271  PHE B CD2   1 ? 
ATOM   6861  C  CE1   . PHE B 1 271 ? -28.241 -24.999 -43.723  1    44.946  ? 271  PHE B CE1   1 ? 
ATOM   6862  C  CE2   . PHE B 1 271 ? -26.579 -25.084 -45.434  1    47.151  ? 271  PHE B CE2   1 ? 
ATOM   6863  C  CZ    . PHE B 1 271 ? -27.409 -24.35  -44.614  1    44.597  ? 271  PHE B CZ    1 ? 
ATOM   6864  N  N     . LYS B 1 272 ? -24.596 -29.755 -44.73   1    46.264  ? 272  LYS B N     1 ? 
ATOM   6865  C  CA    . LYS B 1 272 ? -23.212 -29.811 -45.15   1    44.755  ? 272  LYS B CA    1 ? 
ATOM   6866  C  C     . LYS B 1 272 ? -22.754 -28.422 -45.591  1    52.064  ? 272  LYS B C     1 ? 
ATOM   6867  O  O     . LYS B 1 272 ? -23.34  -27.829 -46.498  1    49.821  ? 272  LYS B O     1 ? 
ATOM   6868  C  CB    . LYS B 1 272 ? -23.14  -30.868 -46.262  1    46.346  ? 272  LYS B CB    1 ? 
ATOM   6869  C  CG    . LYS B 1 272 ? -21.765 -31.141 -46.865  1    52.128  ? 272  LYS B CG    1 ? 
ATOM   6870  C  CD    . LYS B 1 272 ? -20.674 -31.613 -45.911  1    62.525  ? 272  LYS B CD    1 ? 
ATOM   6871  C  CE    . LYS B 1 272 ? -19.375 -31.898 -46.605  1    69.749  ? 272  LYS B CE    1 ? 
ATOM   6872  N  NZ    . LYS B 1 272 ? -18.292 -32.024 -45.621  1    76.529  ? 272  LYS B NZ    1 ? 
ATOM   6873  N  N     . TYR B 1 273 ? -21.705 -27.926 -44.921  1    46.267  ? 273  TYR B N     1 ? 
ATOM   6874  C  CA    . TYR B 1 273 ? -20.928 -26.785 -45.365  1    44.405  ? 273  TYR B CA    1 ? 
ATOM   6875  C  C     . TYR B 1 273 ? -20.139 -27.193 -46.609  1    52.543  ? 273  TYR B C     1 ? 
ATOM   6876  O  O     . TYR B 1 273 ? -19.341 -28.132 -46.562  1    44.422  ? 273  TYR B O     1 ? 
ATOM   6877  C  CB    . TYR B 1 273 ? -20.021 -26.266 -44.241  1    40.644  ? 273  TYR B CB    1 ? 
ATOM   6878  C  CG    . TYR B 1 273 ? -19.087 -25.119 -44.61   1    39.924  ? 273  TYR B CG    1 ? 
ATOM   6879  C  CD1   . TYR B 1 273 ? -17.831 -25.367 -45.158  1    43.255  ? 273  TYR B CD1   1 ? 
ATOM   6880  C  CD2   . TYR B 1 273 ? -19.442 -23.785 -44.401  1    37.021  ? 273  TYR B CD2   1 ? 
ATOM   6881  C  CE1   . TYR B 1 273 ? -16.968 -24.333 -45.503  1    43.93   ? 273  TYR B CE1   1 ? 
ATOM   6882  C  CE2   . TYR B 1 273 ? -18.586 -22.746 -44.753  1    37.43   ? 273  TYR B CE2   1 ? 
ATOM   6883  C  CZ    . TYR B 1 273 ? -17.337 -23.012 -45.295  1    45.926  ? 273  TYR B CZ    1 ? 
ATOM   6884  O  OH    . TYR B 1 273 ? -16.467 -21.987 -45.637  1    42.543  ? 273  TYR B OH    1 ? 
ATOM   6885  N  N     . ASP B 1 274 ? -20.354 -26.46  -47.714  1    49.567  ? 274  ASP B N     1 ? 
ATOM   6886  C  CA    . ASP B 1 274 ? -19.725 -26.765 -48.993  1    48.167  ? 274  ASP B CA    1 ? 
ATOM   6887  C  C     . ASP B 1 274 ? -19.231 -25.458 -49.614  1    43.147  ? 274  ASP B C     1 ? 
ATOM   6888  O  O     . ASP B 1 274 ? -20.027 -24.583 -49.94   1    38.931  ? 274  ASP B O     1 ? 
ATOM   6889  C  CB    . ASP B 1 274 ? -20.679 -27.566 -49.878  1    54.106  ? 274  ASP B CB    1 ? 
ATOM   6890  C  CG    . ASP B 1 274 ? -20.184 -27.975 -51.267  1    53.161  ? 274  ASP B CG    1 ? 
ATOM   6891  O  OD1   . ASP B 1 274 ? -19.013 -27.699 -51.601  1    48.257  ? 274  ASP B OD1   1 ? 
ATOM   6892  O  OD2   . ASP B 1 274 ? -20.991 -28.561 -52.02   1    47.734  ? 274  ASP B OD2   1 ? 
ATOM   6893  N  N     . ILE B 1 275 ? -17.911 -25.334 -49.769  1    35.901  ? 275  ILE B N     1 ? 
ATOM   6894  C  CA    . ILE B 1 275 ? -17.341 -24.112 -50.291  1    39.916  ? 275  ILE B CA    1 ? 
ATOM   6895  C  C     . ILE B 1 275 ? -18.055 -23.714 -51.59   1    46.781  ? 275  ILE B C     1 ? 
ATOM   6896  O  O     . ILE B 1 275 ? -18.336 -22.535 -51.8    1    43.707  ? 275  ILE B O     1 ? 
ATOM   6897  C  CB    . ILE B 1 275 ? -15.806 -24.197 -50.41   1    37.391  ? 275  ILE B CB    1 ? 
ATOM   6898  C  CG1   . ILE B 1 275 ? -15.201 -22.879 -50.877  1    37.712  ? 275  ILE B CG1   1 ? 
ATOM   6899  C  CG2   . ILE B 1 275 ? -15.33  -25.366 -51.277  1    38.703  ? 275  ILE B CG2   1 ? 
ATOM   6900  C  CD1   . ILE B 1 275 ? -15.639 -21.671 -50.059  1    37.77   ? 275  ILE B CD1   1 ? 
ATOM   6901  N  N     . GLU B 1 276 ? -18.374 -24.692 -52.451  1    40.8    ? 276  GLU B N     1 ? 
ATOM   6902  C  CA    . GLU B 1 276 ? -18.996 -24.372 -53.73   1    42.732  ? 276  GLU B CA    1 ? 
ATOM   6903  C  C     . GLU B 1 276 ? -20.361 -23.723 -53.479  1    44.277  ? 276  GLU B C     1 ? 
ATOM   6904  O  O     . GLU B 1 276 ? -20.742 -22.799 -54.193  1    44.519  ? 276  GLU B O     1 ? 
ATOM   6905  C  CB    . GLU B 1 276 ? -19.106 -25.581 -54.666  1    39.633  ? 276  GLU B CB    1 ? 
ATOM   6906  C  CG    . GLU B 1 276 ? -17.824 -26.411 -54.762  1    36.986  ? 276  GLU B CG    1 ? 
ATOM   6907  C  CD    . GLU B 1 276 ? -16.601 -25.713 -55.321  1    45.318  ? 276  GLU B CD    1 ? 
ATOM   6908  O  OE1   . GLU B 1 276 ? -16.714 -24.687 -56.048  1    46.308  ? 276  GLU B OE1   1 ? 
ATOM   6909  O  OE2   . GLU B 1 276 ? -15.501 -26.183 -54.953  1    48.644  ? 276  GLU B OE2   1 ? 
ATOM   6910  N  N     . ARG B 1 277 ? -21.085 -24.186 -52.449  1    38.747  ? 277  ARG B N     1 ? 
ATOM   6911  C  CA    . ARG B 1 277 ? -22.415 -23.666 -52.173  1    38.755  ? 277  ARG B CA    1 ? 
ATOM   6912  C  C     . ARG B 1 277 ? -22.341 -22.285 -51.52   1    43.192  ? 277  ARG B C     1 ? 
ATOM   6913  O  O     . ARG B 1 277 ? -23.228 -21.459 -51.745  1    44.026  ? 277  ARG B O     1 ? 
ATOM   6914  C  CB    . ARG B 1 277 ? -23.336 -24.673 -51.478  1    48.572  ? 277  ARG B CB    1 ? 
ATOM   6915  C  CG    . ARG B 1 277 ? -23.579 -25.93  -52.305  1    52.022  ? 277  ARG B CG    1 ? 
ATOM   6916  C  CD    . ARG B 1 277 ? -24.876 -26.621 -51.91   1    60.154  ? 277  ARG B CD    1 ? 
ATOM   6917  N  NE    . ARG B 1 277 ? -25.307 -27.778 -52.706  1    66.009  ? 277  ARG B NE    1 ? 
ATOM   6918  C  CZ    . ARG B 1 277 ? -24.789 -29.001 -52.644  1    78.07   ? 277  ARG B CZ    1 ? 
ATOM   6919  N  NH1   . ARG B 1 277 ? -23.771 -29.249 -51.831  1    79.036  ? 277  ARG B NH1   1 ? 
ATOM   6920  N  NH2   . ARG B 1 277 ? -25.292 -29.967 -53.399  1    73.922  ? 277  ARG B NH2   1 ? 
ATOM   6921  N  N     . ILE B 1 278 ? -21.266 -22.036 -50.759  1    40.838  ? 278  ILE B N     1 ? 
ATOM   6922  C  CA    . ILE B 1 278 ? -21.036 -20.779 -50.063  1    43.563  ? 278  ILE B CA    1 ? 
ATOM   6923  C  C     . ILE B 1 278 ? -20.684 -19.711 -51.1    1    42.715  ? 278  ILE B C     1 ? 
ATOM   6924  O  O     . ILE B 1 278 ? -21.185 -18.591 -51.046  1    39.623  ? 278  ILE B O     1 ? 
ATOM   6925  C  CB    . ILE B 1 278 ? -19.927 -20.91  -48.991  1    43.722  ? 278  ILE B CB    1 ? 
ATOM   6926  C  CG1   . ILE B 1 278 ? -20.348 -21.8   -47.812  1    41.895  ? 278  ILE B CG1   1 ? 
ATOM   6927  C  CG2   . ILE B 1 278 ? -19.454 -19.535 -48.504  1    37.83   ? 278  ILE B CG2   1 ? 
ATOM   6928  C  CD1   . ILE B 1 278 ? -21.406 -21.177 -46.914  1    41.807  ? 278  ILE B CD1   1 ? 
ATOM   6929  N  N     . ILE B 1 279 ? -19.802 -20.079 -52.029  1    38.675  ? 279  ILE B N     1 ? 
ATOM   6930  C  CA    . ILE B 1 279 ? -19.446 -19.223 -53.145  1    38.005  ? 279  ILE B CA    1 ? 
ATOM   6931  C  C     . ILE B 1 279 ? -20.697 -18.81  -53.929  1    38.166  ? 279  ILE B C     1 ? 
ATOM   6932  O  O     . ILE B 1 279 ? -20.811 -17.655 -54.322  1    38.799  ? 279  ILE B O     1 ? 
ATOM   6933  C  CB    . ILE B 1 279 ? -18.376 -19.874 -54.028  1    40.111  ? 279  ILE B CB    1 ? 
ATOM   6934  C  CG1   . ILE B 1 279 ? -17.031 -19.891 -53.317  1    41.684  ? 279  ILE B CG1   1 ? 
ATOM   6935  C  CG2   . ILE B 1 279 ? -18.289 -19.149 -55.377  1    47.775  ? 279  ILE B CG2   1 ? 
ATOM   6936  C  CD1   . ILE B 1 279 ? -16.054 -20.929 -53.847  1    52.111  ? 279  ILE B CD1   1 ? 
ATOM   6937  N  N     . ASP B 1 280 ? -21.654 -19.721 -54.117  1    39.246  ? 280  ASP B N     1 ? 
ATOM   6938  C  CA    . ASP B 1 280 ? -22.849 -19.371 -54.871  1    41.35   ? 280  ASP B CA    1 ? 
ATOM   6939  C  C     . ASP B 1 280 ? -23.654 -18.283 -54.155  1    45.554  ? 280  ASP B C     1 ? 
ATOM   6940  O  O     . ASP B 1 280 ? -24.168 -17.38  -54.817  1    40.316  ? 280  ASP B O     1 ? 
ATOM   6941  C  CB    . ASP B 1 280 ? -23.683 -20.57  -55.294  1    37.867  ? 280  ASP B CB    1 ? 
ATOM   6942  C  CG    . ASP B 1 280 ? -23.119 -21.423 -56.422  1    39.406  ? 280  ASP B CG    1 ? 
ATOM   6943  O  OD1   . ASP B 1 280 ? -22.192 -20.959 -57.119  1    40.736  ? 280  ASP B OD1   1 ? 
ATOM   6944  O  OD2   . ASP B 1 280 ? -23.578 -22.58  -56.554  1    43.303  ? 280  ASP B OD2   1 ? 
ATOM   6945  N  N     . ASP B 1 281 ? -23.77  -18.381 -52.82   1    39.849  ? 281  ASP B N     1 ? 
ATOM   6946  C  CA    . ASP B 1 281 ? -24.472 -17.376 -52.03   1    42.131  ? 281  ASP B CA    1 ? 
ATOM   6947  C  C     . ASP B 1 281 ? -23.686 -16.062 -51.962  1    39.893  ? 281  ASP B C     1 ? 
ATOM   6948  O  O     . ASP B 1 281 ? -24.274 -14.977 -51.967  1    36.344  ? 281  ASP B O     1 ? 
ATOM   6949  C  CB    . ASP B 1 281 ? -24.932 -17.939 -50.688  1    48.737  ? 281  ASP B CB    1 ? 
ATOM   6950  C  CG    . ASP B 1 281 ? -26.149 -18.856 -50.759  1    49.73   ? 281  ASP B CG    1 ? 
ATOM   6951  O  OD1   . ASP B 1 281 ? -26.642 -19.068 -51.879  1    54.265  ? 281  ASP B OD1   1 ? 
ATOM   6952  O  OD2   . ASP B 1 281 ? -26.631 -19.317 -49.698  1    47.107  ? 281  ASP B OD2   1 ? 
ATOM   6953  N  N     . TRP B 1 282 ? -22.355 -16.164 -51.867  1    39.49   ? 282  TRP B N     1 ? 
ATOM   6954  C  CA    . TRP B 1 282 ? -21.475 -15.012 -51.937  1    40.653  ? 282  TRP B CA    1 ? 
ATOM   6955  C  C     . TRP B 1 282 ? -21.733 -14.257 -53.245  1    46.347  ? 282  TRP B C     1 ? 
ATOM   6956  O  O     . TRP B 1 282 ? -21.861 -13.027 -53.267  1    42.922  ? 282  TRP B O     1 ? 
ATOM   6957  C  CB    . TRP B 1 282 ? -20.026 -15.495 -51.873  1    36.388  ? 282  TRP B CB    1 ? 
ATOM   6958  C  CG    . TRP B 1 282 ? -18.984 -14.42  -51.702  1    36.847  ? 282  TRP B CG    1 ? 
ATOM   6959  C  CD1   . TRP B 1 282 ? -18.429 -14.024 -50.519  1    41.83   ? 282  TRP B CD1   1 ? 
ATOM   6960  C  CD2   . TRP B 1 282 ? -18.323 -13.637 -52.729  1    39.475  ? 282  TRP B CD2   1 ? 
ATOM   6961  N  NE1   . TRP B 1 282 ? -17.474 -13.062 -50.73   1    39.441  ? 282  TRP B NE1   1 ? 
ATOM   6962  C  CE2   . TRP B 1 282 ? -17.39  -12.799 -52.074  1    37.138  ? 282  TRP B CE2   1 ? 
ATOM   6963  C  CE3   . TRP B 1 282 ? -18.418 -13.555 -54.123  1    37.181  ? 282  TRP B CE3   1 ? 
ATOM   6964  C  CZ2   . TRP B 1 282 ? -16.578 -11.898 -52.763  1    37.661  ? 282  TRP B CZ2   1 ? 
ATOM   6965  C  CZ3   . TRP B 1 282 ? -17.613 -12.662 -54.801  1    36.56   ? 282  TRP B CZ3   1 ? 
ATOM   6966  C  CH2   . TRP B 1 282 ? -16.693 -11.85  -54.135  1    36.985  ? 282  TRP B CH2   1 ? 
ATOM   6967  N  N     . ILE B 1 283 ? -21.798 -15.013 -54.344  1    42.413  ? 283  ILE B N     1 ? 
ATOM   6968  C  CA    . ILE B 1 283 ? -22.101 -14.432 -55.647  1    45.673  ? 283  ILE B CA    1 ? 
ATOM   6969  C  C     . ILE B 1 283 ? -23.458 -13.72  -55.616  1    40.044  ? 283  ILE B C     1 ? 
ATOM   6970  O  O     . ILE B 1 283 ? -23.575 -12.607 -56.119  1    38.417  ? 283  ILE B O     1 ? 
ATOM   6971  C  CB    . ILE B 1 283 ? -21.988 -15.476 -56.777  1    39.389  ? 283  ILE B CB    1 ? 
ATOM   6972  C  CG1   . ILE B 1 283 ? -20.541 -15.895 -56.965  1    34.914  ? 283  ILE B CG1   1 ? 
ATOM   6973  C  CG2   . ILE B 1 283 ? -22.566 -14.944 -58.098  1    43.044  ? 283  ILE B CG2   1 ? 
ATOM   6974  C  CD1   . ILE B 1 283 ? -20.392 -17.261 -57.621  1    37.164  ? 283  ILE B CD1   1 ? 
ATOM   6975  N  N     . LEU B 1 284 ? -24.481 -14.362 -55.036  1    35.735  ? 284  LEU B N     1 ? 
ATOM   6976  C  CA    . LEU B 1 284 ? -25.813 -13.772 -55.002  1    37.973  ? 284  LEU B CA    1 ? 
ATOM   6977  C  C     . LEU B 1 284 ? -25.81  -12.438 -54.254  1    40.884  ? 284  LEU B C     1 ? 
ATOM   6978  O  O     . LEU B 1 284 ? -26.524 -11.505 -54.617  1    39.239  ? 284  LEU B O     1 ? 
ATOM   6979  C  CB    . LEU B 1 284 ? -26.812 -14.752 -54.391  1    33.285  ? 284  LEU B CB    1 ? 
ATOM   6980  C  CG    . LEU B 1 284 ? -28.17  -14.152 -54.011  1    36.717  ? 284  LEU B CG    1 ? 
ATOM   6981  C  CD1   . LEU B 1 284 ? -28.964 -13.702 -55.228  1    36.102  ? 284  LEU B CD1   1 ? 
ATOM   6982  C  CD2   . LEU B 1 284 ? -28.993 -15.103 -53.159  1    33.489  ? 284  LEU B CD2   1 ? 
ATOM   6983  N  N     . MET B 1 285 ? -25.015 -12.361 -53.182  1    45.155  ? 285  MET B N     1 ? 
ATOM   6984  C  CA    . MET B 1 285 ? -24.961 -11.158 -52.362  1    42.121  ? 285  MET B CA    1 ? 
ATOM   6985  C  C     . MET B 1 285 ? -24.268 -10.037 -53.133  1    39.789  ? 285  MET B C     1 ? 
ATOM   6986  O  O     . MET B 1 285 ? -24.693 -8.885  -53.05   1    39.77   ? 285  MET B O     1 ? 
ATOM   6987  C  CB    . MET B 1 285 ? -24.323 -11.433 -50.994  1    38.36   ? 285  MET B CB    1 ? 
ATOM   6988  C  CG    . MET B 1 285 ? -25.254 -12.225 -50.062  1    40.707  ? 285  MET B CG    1 ? 
ATOM   6989  S  SD    . MET B 1 285 ? -24.63  -12.644 -48.414  1    44.977  ? 285  MET B SD    1 ? 
ATOM   6990  C  CE    . MET B 1 285 ? -23.289 -13.776 -48.808  1    43.066  ? 285  MET B CE    1 ? 
ATOM   6991  N  N     . GLY B 1 286 ? -23.225 -10.39  -53.896  1    37.047  ? 286  GLY B N     1 ? 
ATOM   6992  C  CA    . GLY B 1 286 ? -22.544 -9.444  -54.77   1    42.279  ? 286  GLY B CA    1 ? 
ATOM   6993  C  C     . GLY B 1 286 ? -23.512 -8.811  -55.777  1    47.052  ? 286  GLY B C     1 ? 
ATOM   6994  O  O     . GLY B 1 286 ? -23.416 -7.619  -56.077  1    46.194  ? 286  GLY B O     1 ? 
ATOM   6995  N  N     . PHE B 1 287 ? -24.462 -9.621  -56.265  1    39.772  ? 287  PHE B N     1 ? 
ATOM   6996  C  CA    . PHE B 1 287 ? -25.486 -9.159  -57.183  1    42.611  ? 287  PHE B CA    1 ? 
ATOM   6997  C  C     . PHE B 1 287 ? -26.428 -8.187  -56.479  1    44.275  ? 287  PHE B C     1 ? 
ATOM   6998  O  O     . PHE B 1 287 ? -26.986 -7.296  -57.116  1    45.349  ? 287  PHE B O     1 ? 
ATOM   6999  C  CB    . PHE B 1 287 ? -26.323 -10.224 -57.904  1    40.132  ? 287  PHE B CB    1 ? 
ATOM   7000  C  CG    . PHE B 1 287 ? -25.595 -11.122 -58.899  1    44.709  ? 287  PHE B CG    1 ? 
ATOM   7001  C  CD1   . PHE B 1 287 ? -24.374 -10.746 -59.454  1    42.493  ? 287  PHE B CD1   1 ? 
ATOM   7002  C  CD2   . PHE B 1 287 ? -26.133 -12.354 -59.271  1    45.343  ? 287  PHE B CD2   1 ? 
ATOM   7003  C  CE1   . PHE B 1 287 ? -23.713 -11.568 -60.359  1    49.023  ? 287  PHE B CE1   1 ? 
ATOM   7004  C  CE2   . PHE B 1 287 ? -25.463 -13.172 -60.176  1    48.937  ? 287  PHE B CE2   1 ? 
ATOM   7005  C  CZ    . PHE B 1 287 ? -24.254 -12.779 -60.718  1    43.036  ? 287  PHE B CZ    1 ? 
ATOM   7006  N  N     . LEU B 1 288 ? -26.621 -8.369  -55.176  1    42.267  ? 288  LEU B N     1 ? 
ATOM   7007  C  CA    . LEU B 1 288 ? -27.633 -7.594  -54.49   1    40.84   ? 288  LEU B CA    1 ? 
ATOM   7008  C  C     . LEU B 1 288 ? -27.142 -6.165  -54.337  1    40.132  ? 288  LEU B C     1 ? 
ATOM   7009  O  O     . LEU B 1 288 ? -27.94  -5.257  -54.162  1    47.591  ? 288  LEU B O     1 ? 
ATOM   7010  C  CB    . LEU B 1 288 ? -27.969 -8.245  -53.152  1    43.85   ? 288  LEU B CB    1 ? 
ATOM   7011  C  CG    . LEU B 1 288 ? -28.886 -9.461  -53.26   1    50.767  ? 288  LEU B CG    1 ? 
ATOM   7012  C  CD1   . LEU B 1 288 ? -29.104 -10.139 -51.921  1    47.755  ? 288  LEU B CD1   1 ? 
ATOM   7013  C  CD2   . LEU B 1 288 ? -30.221 -9.028  -53.859  1    53.178  ? 288  LEU B CD2   1 ? 
ATOM   7014  N  N     . VAL B 1 289 ? -25.827 -5.982  -54.43   1    41.817  ? 289  VAL B N     1 ? 
ATOM   7015  C  CA    . VAL B 1 289 ? -25.263 -4.669  -54.213  1    47.582  ? 289  VAL B CA    1 ? 
ATOM   7016  C  C     . VAL B 1 289 ? -24.74  -4.108  -55.53   1    46.784  ? 289  VAL B C     1 ? 
ATOM   7017  O  O     . VAL B 1 289 ? -24.285 -2.975  -55.557  1    60.681  ? 289  VAL B O     1 ? 
ATOM   7018  C  CB    . VAL B 1 289 ? -24.179 -4.608  -53.114  1    45.296  ? 289  VAL B CB    1 ? 
ATOM   7019  C  CG1   . VAL B 1 289 ? -24.693 -5.145  -51.78   1    39.681  ? 289  VAL B CG1   1 ? 
ATOM   7020  C  CG2   . VAL B 1 289 ? -22.867 -5.266  -53.542  1    41.6    ? 289  VAL B CG2   1 ? 
ATOM   7021  N  N     . GLY B 1 290 ? -24.783 -4.893  -56.607  1    54.682  ? 290  GLY B N     1 ? 
ATOM   7022  C  CA    . GLY B 1 290 ? -24.308 -4.417  -57.901  1    62.477  ? 290  GLY B CA    1 ? 
ATOM   7023  C  C     . GLY B 1 290 ? -25.19  -3.28   -58.413  1    60.553  ? 290  GLY B C     1 ? 
ATOM   7024  O  O     . GLY B 1 290 ? -26.406 -3.361  -58.285  1    59.928  ? 290  GLY B O     1 ? 
ATOM   7025  N  N     . ASN B 1 291 ? -24.569 -2.222  -58.961  1    65.94   ? 291  ASN B N     1 ? 
ATOM   7026  C  CA    . ASN B 1 291 ? -25.292 -1.105  -59.568  1    68.779  ? 291  ASN B CA    1 ? 
ATOM   7027  C  C     . ASN B 1 291 ? -25.098 -1.119  -61.083  1    75.937  ? 291  ASN B C     1 ? 
ATOM   7028  O  O     . ASN B 1 291 ? -25.569 -0.228  -61.793  1    66.524  ? 291  ASN B O     1 ? 
ATOM   7029  C  CB    . ASN B 1 291 ? -24.91  0.242   -58.953  1    64.015  ? 291  ASN B CB    1 ? 
ATOM   7030  C  CG    . ASN B 1 291 ? -25.166 0.289   -57.462  1    67.52   ? 291  ASN B CG    1 ? 
ATOM   7031  O  OD1   . ASN B 1 291 ? -26.315 0.135   -57.014  1    64.161  ? 291  ASN B OD1   1 ? 
ATOM   7032  N  ND2   . ASN B 1 291 ? -24.106 0.48    -56.684  1    67.467  ? 291  ASN B ND2   1 ? 
ATOM   7033  N  N     . ASP B 1 292 ? -24.422 -2.176  -61.55   1    95.309  ? 292  ASP B N     1 ? 
ATOM   7034  C  CA    . ASP B 1 292 ? -23.985 -2.359  -62.924  1    96.558  ? 292  ASP B CA    1 ? 
ATOM   7035  C  C     . ASP B 1 292 ? -25.086 -3.07   -63.719  1    91.447  ? 292  ASP B C     1 ? 
ATOM   7036  O  O     . ASP B 1 292 ? -24.916 -3.366  -64.902  1    90.213  ? 292  ASP B O     1 ? 
ATOM   7037  C  CB    . ASP B 1 292 ? -22.612 -3.019  -62.911  1    115.905 ? 292  ASP B CB    1 ? 
ATOM   7038  C  CG    . ASP B 1 292 ? -21.929 -3.251  -64.252  1    132.213 ? 292  ASP B CG    1 ? 
ATOM   7039  O  OD1   . ASP B 1 292 ? -21.727 -2.263  -64.99   1    140.936 ? 292  ASP B OD1   1 ? 
ATOM   7040  O  OD2   . ASP B 1 292 ? -21.578 -4.42   -64.528  1    136.921 ? 292  ASP B OD2   1 ? 
ATOM   7041  N  N     . PHE B 1 293 ? -26.224 -3.335  -63.064  1    83.078  ? 293  PHE B N     1 ? 
ATOM   7042  C  CA    . PHE B 1 293 ? -27.344 -3.977  -63.73   1    76.967  ? 293  PHE B CA    1 ? 
ATOM   7043  C  C     . PHE B 1 293 ? -28.638 -3.244  -63.383  1    72.965  ? 293  PHE B C     1 ? 
ATOM   7044  O  O     . PHE B 1 293 ? -29.231 -2.605  -64.259  1    61.743  ? 293  PHE B O     1 ? 
ATOM   7045  C  CB    . PHE B 1 293 ? -27.454 -5.484  -63.483  1    86.343  ? 293  PHE B CB    1 ? 
ATOM   7046  C  CG    . PHE B 1 293 ? -28.604 -6.094  -64.275  1    90.343  ? 293  PHE B CG    1 ? 
ATOM   7047  C  CD1   . PHE B 1 293 ? -28.404 -6.567  -65.568  1    85.778  ? 293  PHE B CD1   1 ? 
ATOM   7048  C  CD2   . PHE B 1 293 ? -29.886 -6.166  -63.737  1    89.001  ? 293  PHE B CD2   1 ? 
ATOM   7049  C  CE1   . PHE B 1 293 ? -29.452 -7.116  -66.289  1    85.152  ? 293  PHE B CE1   1 ? 
ATOM   7050  C  CE2   . PHE B 1 293 ? -30.932 -6.709  -64.465  1    87.168  ? 293  PHE B CE2   1 ? 
ATOM   7051  C  CZ    . PHE B 1 293 ? -30.712 -7.184  -65.736  1    86.37   ? 293  PHE B CZ    1 ? 
ATOM   7052  N  N     . ILE B 1 294 ? -29.102 -3.393  -62.129  1    62.35   ? 294  ILE B N     1 ? 
ATOM   7053  C  CA    . ILE B 1 294 ? -30.135 -2.495  -61.636  1    56.085  ? 294  ILE B CA    1 ? 
ATOM   7054  C  C     . ILE B 1 294 ? -29.602 -1.691  -60.458  1    65.367  ? 294  ILE B C     1 ? 
ATOM   7055  O  O     . ILE B 1 294 ? -29.435 -2.226  -59.357  1    63.949  ? 294  ILE B O     1 ? 
ATOM   7056  C  CB    . ILE B 1 294 ? -31.477 -3.157  -61.311  1    44.818  ? 294  ILE B CB    1 ? 
ATOM   7057  C  CG1   . ILE B 1 294 ? -31.942 -4.076  -62.446  1    44.978  ? 294  ILE B CG1   1 ? 
ATOM   7058  C  CG2   . ILE B 1 294 ? -32.488 -2.053  -61.007  1    39.442  ? 294  ILE B CG2   1 ? 
ATOM   7059  C  CD1   . ILE B 1 294 ? -32.917 -5.161  -62.024  1    44.419  ? 294  ILE B CD1   1 ? 
ATOM   7060  N  N     . PRO B 1 295 ? -29.358 -0.377  -60.693  1    70.519  ? 295  PRO B N     1 ? 
ATOM   7061  C  CA    . PRO B 1 295 ? -28.798 0.528   -59.683  1    68.979  ? 295  PRO B CA    1 ? 
ATOM   7062  C  C     . PRO B 1 295 ? -29.695 0.742   -58.464  1    67.504  ? 295  PRO B C     1 ? 
ATOM   7063  O  O     . PRO B 1 295 ? -30.921 0.656   -58.556  1    69.963  ? 295  PRO B O     1 ? 
ATOM   7064  C  CB    . PRO B 1 295 ? -28.59  1.84    -60.475  1    72.569  ? 295  PRO B CB    1 ? 
ATOM   7065  C  CG    . PRO B 1 295 ? -28.618 1.427   -61.938  1    75.992  ? 295  PRO B CG    1 ? 
ATOM   7066  C  CD    . PRO B 1 295 ? -29.616 0.291   -61.984  1    67.795  ? 295  PRO B CD    1 ? 
ATOM   7067  N  N     . HIS B 1 296 ? -29.071 1.008   -57.314  1    59.031  ? 296  HIS B N     1 ? 
ATOM   7068  C  CA    . HIS B 1 296 ? -29.83  1.501   -56.178  1    60.291  ? 296  HIS B CA    1 ? 
ATOM   7069  C  C     . HIS B 1 296 ? -29.781 3.029   -56.168  1    55.007  ? 296  HIS B C     1 ? 
ATOM   7070  O  O     . HIS B 1 296 ? -28.808 3.623   -56.645  1    47.329  ? 296  HIS B O     1 ? 
ATOM   7071  C  CB    . HIS B 1 296 ? -29.287 0.911   -54.875  1    62.534  ? 296  HIS B CB    1 ? 
ATOM   7072  C  CG    . HIS B 1 296 ? -29.494 -0.559  -54.776  1    65.055  ? 296  HIS B CG    1 ? 
ATOM   7073  N  ND1   . HIS B 1 296 ? -30.549 -1.12   -54.089  1    61.172  ? 296  HIS B ND1   1 ? 
ATOM   7074  C  CD2   . HIS B 1 296 ? -28.779 -1.579  -55.265  1    63.462  ? 296  HIS B CD2   1 ? 
ATOM   7075  C  CE1   . HIS B 1 296 ? -30.464 -2.437  -54.165  1    57.846  ? 296  HIS B CE1   1 ? 
ATOM   7076  N  NE2   . HIS B 1 296 ? -29.402 -2.737  -54.877  1    56.552  ? 296  HIS B NE2   1 ? 
ATOM   7077  N  N     . LEU B 1 297 ? -30.849 3.64    -55.632  1    53.882  ? 297  LEU B N     1 ? 
ATOM   7078  C  CA    . LEU B 1 297 ? -30.935 5.078   -55.394  1    61.615  ? 297  LEU B CA    1 ? 
ATOM   7079  C  C     . LEU B 1 297 ? -29.612 5.589   -54.812  1    64.502  ? 297  LEU B C     1 ? 
ATOM   7080  O  O     . LEU B 1 297 ? -29.128 5.009   -53.84   1    61.123  ? 297  LEU B O     1 ? 
ATOM   7081  C  CB    . LEU B 1 297 ? -32.118 5.314   -54.452  1    56.451  ? 297  LEU B CB    1 ? 
ATOM   7082  C  CG    . LEU B 1 297 ? -33.509 5.06    -55.056  1    59.28   ? 297  LEU B CG    1 ? 
ATOM   7083  C  CD1   . LEU B 1 297 ? -34.635 4.974   -54.032  1    52.019  ? 297  LEU B CD1   1 ? 
ATOM   7084  C  CD2   . LEU B 1 297 ? -33.839 6.113   -56.11   1    52.446  ? 297  LEU B CD2   1 ? 
ATOM   7085  N  N     . PRO B 1 298 ? -28.977 6.652   -55.389  1    70.381  ? 298  PRO B N     1 ? 
ATOM   7086  C  CA    . PRO B 1 298 ? -27.631 7.09    -54.973  1    73.463  ? 298  PRO B CA    1 ? 
ATOM   7087  C  C     . PRO B 1 298 ? -27.409 7.361   -53.479  1    77.521  ? 298  PRO B C     1 ? 
ATOM   7088  O  O     . PRO B 1 298 ? -26.301 7.172   -52.97   1    68.672  ? 298  PRO B O     1 ? 
ATOM   7089  C  CB    . PRO B 1 298 ? -27.304 8.342   -55.837  1    71.948  ? 298  PRO B CB    1 ? 
ATOM   7090  C  CG    . PRO B 1 298 ? -28.341 8.332   -56.953  1    70.186  ? 298  PRO B CG    1 ? 
ATOM   7091  C  CD    . PRO B 1 298 ? -29.528 7.492   -56.473  1    68.53   ? 298  PRO B CD    1 ? 
ATOM   7092  N  N     . HIS B 1 299 ? -28.484 7.768   -52.782  1    79.8    ? 299  HIS B N     1 ? 
ATOM   7093  C  CA    . HIS B 1 299 ? -28.435 8.238   -51.402  1    83.299  ? 299  HIS B CA    1 ? 
ATOM   7094  C  C     . HIS B 1 299 ? -28.542 7.086   -50.395  1    82.412  ? 299  HIS B C     1 ? 
ATOM   7095  O  O     . HIS B 1 299 ? -28.482 7.328   -49.193  1    91.895  ? 299  HIS B O     1 ? 
ATOM   7096  C  CB    . HIS B 1 299 ? -29.449 9.375   -51.177  1    85.583  ? 299  HIS B CB    1 ? 
ATOM   7097  C  CG    . HIS B 1 299 ? -29.037 10.711  -51.729  1    91.492  ? 299  HIS B CG    1 ? 
ATOM   7098  N  ND1   . HIS B 1 299 ? -29.896 11.521  -52.446  1    94.09   ? 299  HIS B ND1   1 ? 
ATOM   7099  C  CD2   . HIS B 1 299 ? -27.863 11.362  -51.691  1    84.607  ? 299  HIS B CD2   1 ? 
ATOM   7100  C  CE1   . HIS B 1 299 ? -29.26  12.625  -52.816  1    89.081  ? 299  HIS B CE1   1 ? 
ATOM   7101  N  NE2   . HIS B 1 299 ? -28.022 12.546  -52.37   1    91.015  ? 299  HIS B NE2   1 ? 
ATOM   7102  N  N     . LEU B 1 300 ? -28.675 5.837   -50.872  1    76.411  ? 300  LEU B N     1 ? 
ATOM   7103  C  CA    . LEU B 1 300 ? -28.741 4.671   -49.996  1    68.958  ? 300  LEU B CA    1 ? 
ATOM   7104  C  C     . LEU B 1 300 ? -27.345 4.085   -49.78   1    61.86   ? 300  LEU B C     1 ? 
ATOM   7105  O  O     . LEU B 1 300 ? -27.154 3.254   -48.896  1    68.76   ? 300  LEU B O     1 ? 
ATOM   7106  C  CB    . LEU B 1 300 ? -29.724 3.601   -50.472  1    61.721  ? 300  LEU B CB    1 ? 
ATOM   7107  C  CG    . LEU B 1 300 ? -31.191 4.023   -50.599  1    65.503  ? 300  LEU B CG    1 ? 
ATOM   7108  C  CD1   . LEU B 1 300 ? -32.118 2.817   -50.783  1    64.127  ? 300  LEU B CD1   1 ? 
ATOM   7109  C  CD2   . LEU B 1 300 ? -31.646 4.913   -49.453  1    59.986  ? 300  LEU B CD2   1 ? 
ATOM   7110  N  N     . HIS B 1 301 ? -26.379 4.52    -50.6    1    63.079  ? 301  HIS B N     1 ? 
ATOM   7111  C  CA    . HIS B 1 301 ? -24.994 4.085   -50.494  1    70.587  ? 301  HIS B CA    1 ? 
ATOM   7112  C  C     . HIS B 1 301 ? -24.898 2.557   -50.462  1    71.983  ? 301  HIS B C     1 ? 
ATOM   7113  O  O     . HIS B 1 301 ? -23.979 2.002   -49.859  1    77.717  ? 301  HIS B O     1 ? 
ATOM   7114  C  CB    . HIS B 1 301 ? -24.3   4.761   -49.301  1    77.934  ? 301  HIS B CB    1 ? 
ATOM   7115  C  CG    . HIS B 1 301 ? -24.004 6.216   -49.493  1    93.687  ? 301  HIS B CG    1 ? 
ATOM   7116  N  ND1   . HIS B 1 301 ? -24.952 7.204   -49.33   1    98.435  ? 301  HIS B ND1   1 ? 
ATOM   7117  C  CD2   . HIS B 1 301 ? -22.87  6.845   -49.837  1    96.56   ? 301  HIS B CD2   1 ? 
ATOM   7118  C  CE1   . HIS B 1 301 ? -24.402 8.386   -49.569  1    103.274 ? 301  HIS B CE1   1 ? 
ATOM   7119  N  NE2   . HIS B 1 301 ? -23.138 8.19    -49.878  1    105.944 ? 301  HIS B NE2   1 ? 
ATOM   7120  N  N     . ILE B 1 302 ? -25.842 1.874   -51.121  1    61.404  ? 302  ILE B N     1 ? 
ATOM   7121  C  CA    . ILE B 1 302 ? -25.72  0.439   -51.316  1    62.309  ? 302  ILE B CA    1 ? 
ATOM   7122  C  C     . ILE B 1 302 ? -24.729 0.18    -52.448  1    59.258  ? 302  ILE B C     1 ? 
ATOM   7123  O  O     . ILE B 1 302 ? -25.028 0.382   -53.621  1    66.344  ? 302  ILE B O     1 ? 
ATOM   7124  C  CB    . ILE B 1 302 ? -27.076 -0.24   -51.575  1    60.853  ? 302  ILE B CB    1 ? 
ATOM   7125  C  CG1   . ILE B 1 302 ? -28.084 0.112   -50.5    1    57.316  ? 302  ILE B CG1   1 ? 
ATOM   7126  C  CG2   . ILE B 1 302 ? -26.892 -1.755  -51.69   1    61.542  ? 302  ILE B CG2   1 ? 
ATOM   7127  C  CD1   . ILE B 1 302 ? -29.521 -0.192  -50.88   1    59.534  ? 302  ILE B CD1   1 ? 
ATOM   7128  N  N     . ASN B 1 303 ? -23.535 -0.26   -52.062  1    53.206  ? 303  ASN B N     1 ? 
ATOM   7129  C  CA    . ASN B 1 303 ? -22.489 -0.682  -52.972  1    51.423  ? 303  ASN B CA    1 ? 
ATOM   7130  C  C     . ASN B 1 303 ? -21.678 -1.75   -52.237  1    57.422  ? 303  ASN B C     1 ? 
ATOM   7131  O  O     . ASN B 1 303 ? -22.195 -2.397  -51.313  1    44.862  ? 303  ASN B O     1 ? 
ATOM   7132  C  CB    . ASN B 1 303 ? -21.626 0.507   -53.381  1    56.736  ? 303  ASN B CB    1 ? 
ATOM   7133  C  CG    . ASN B 1 303 ? -20.929 1.116   -52.182  1    71.571  ? 303  ASN B CG    1 ? 
ATOM   7134  O  OD1   . ASN B 1 303 ? -21.529 1.221   -51.102  1    79.847  ? 303  ASN B OD1   1 ? 
ATOM   7135  N  ND2   . ASN B 1 303 ? -19.659 1.469   -52.327  1    65.231  ? 303  ASN B ND2   1 ? 
ATOM   7136  N  N     . HIS B 1 304 ? -20.396 -1.855  -52.626  1    56.054  ? 304  HIS B N     1 ? 
ATOM   7137  C  CA    . HIS B 1 304 ? -19.431 -2.837  -52.153  1    61.288  ? 304  HIS B CA    1 ? 
ATOM   7138  C  C     . HIS B 1 304 ? -19.25  -2.749  -50.633  1    63.365  ? 304  HIS B C     1 ? 
ATOM   7139  O  O     . HIS B 1 304 ? -19.179 -3.774  -49.95   1    64.532  ? 304  HIS B O     1 ? 
ATOM   7140  C  CB    . HIS B 1 304 ? -18.134 -2.673  -52.955  1    67.153  ? 304  HIS B CB    1 ? 
ATOM   7141  C  CG    . HIS B 1 304 ? -18.362 -2.683  -54.434  1    88.154  ? 304  HIS B CG    1 ? 
ATOM   7142  N  ND1   . HIS B 1 304 ? -19.471 -3.264  -55.019  1    96.208  ? 304  HIS B ND1   1 ? 
ATOM   7143  C  CD2   . HIS B 1 304 ? -17.64  -2.176  -55.444  1    97.557  ? 304  HIS B CD2   1 ? 
ATOM   7144  C  CE1   . HIS B 1 304 ? -19.41  -3.115  -56.335  1    98.981  ? 304  HIS B CE1   1 ? 
ATOM   7145  N  NE2   . HIS B 1 304 ? -18.302 -2.461  -56.616  1    102.92  ? 304  HIS B NE2   1 ? 
ATOM   7146  N  N     . ASP B 1 305 ? -19.21  -1.52   -50.104  1    56.596  ? 305  ASP B N     1 ? 
ATOM   7147  C  CA    . ASP B 1 305 ? -19.029 -1.3    -48.676  1    57.17   ? 305  ASP B CA    1 ? 
ATOM   7148  C  C     . ASP B 1 305 ? -20.178 -1.879  -47.86   1    47.691  ? 305  ASP B C     1 ? 
ATOM   7149  O  O     . ASP B 1 305 ? -19.999 -2.125  -46.672  1    52.579  ? 305  ASP B O     1 ? 
ATOM   7150  C  CB    . ASP B 1 305 ? -18.755 0.155   -48.358  1    57.895  ? 305  ASP B CB    1 ? 
ATOM   7151  C  CG    . ASP B 1 305 ? -17.482 0.693   -48.986  1    61.201  ? 305  ASP B CG    1 ? 
ATOM   7152  O  OD1   . ASP B 1 305 ? -16.465 -0.033  -48.968  1    69.443  ? 305  ASP B OD1   1 ? 
ATOM   7153  O  OD2   . ASP B 1 305 ? -17.522 1.834   -49.47   1    74.386  ? 305  ASP B OD2   1 ? 
ATOM   7154  N  N     . ALA B 1 306 ? -21.335 -2.126  -48.491  1    40.307  ? 306  ALA B N     1 ? 
ATOM   7155  C  CA    . ALA B 1 306 ? -22.442 -2.777  -47.794  1    43.899  ? 306  ALA B CA    1 ? 
ATOM   7156  C  C     . ALA B 1 306 ? -22.26  -4.294  -47.696  1    42.6    ? 306  ALA B C     1 ? 
ATOM   7157  O  O     . ALA B 1 306 ? -22.971 -4.954  -46.94   1    40.928  ? 306  ALA B O     1 ? 
ATOM   7158  C  CB    . ALA B 1 306 ? -23.765 -2.458  -48.453  1    44.268  ? 306  ALA B CB    1 ? 
ATOM   7159  N  N     . LEU B 1 307 ? -21.329 -4.856  -48.473  1    40.298  ? 307  LEU B N     1 ? 
ATOM   7160  C  CA    . LEU B 1 307 ? -21.171 -6.305  -48.485  1    42.7    ? 307  LEU B CA    1 ? 
ATOM   7161  C  C     . LEU B 1 307 ? -20.953 -6.884  -47.079  1    45.944  ? 307  LEU B C     1 ? 
ATOM   7162  O  O     . LEU B 1 307 ? -21.706 -7.77   -46.654  1    41.798  ? 307  LEU B O     1 ? 
ATOM   7163  C  CB    . LEU B 1 307 ? -20.084 -6.658  -49.496  1    43.199  ? 307  LEU B CB    1 ? 
ATOM   7164  C  CG    . LEU B 1 307 ? -20.592 -6.682  -50.944  1    39.289  ? 307  LEU B CG    1 ? 
ATOM   7165  C  CD1   . LEU B 1 307 ? -19.524 -6.938  -51.984  1    37.649  ? 307  LEU B CD1   1 ? 
ATOM   7166  C  CD2   . LEU B 1 307 ? -21.726 -7.723  -51.015  1    35.085  ? 307  LEU B CD2   1 ? 
ATOM   7167  N  N     . PRO B 1 308 ? -19.983 -6.37   -46.278  1    50.281  ? 308  PRO B N     1 ? 
ATOM   7168  C  CA    . PRO B 1 308 ? -19.77  -6.882  -44.919  1    48.264  ? 308  PRO B CA    1 ? 
ATOM   7169  C  C     . PRO B 1 308 ? -21.073 -7.008  -44.127  1    44.869  ? 308  PRO B C     1 ? 
ATOM   7170  O  O     . PRO B 1 308 ? -21.277 -7.977  -43.399  1    46.334  ? 308  PRO B O     1 ? 
ATOM   7171  C  CB    . PRO B 1 308 ? -18.762 -5.864  -44.338  1    49.468  ? 308  PRO B CB    1 ? 
ATOM   7172  C  CG    . PRO B 1 308 ? -17.966 -5.428  -45.539  1    51.004  ? 308  PRO B CG    1 ? 
ATOM   7173  C  CD    . PRO B 1 308 ? -19.042 -5.284  -46.623  1    51.463  ? 308  PRO B CD    1 ? 
ATOM   7174  N  N     . LEU B 1 309 ? -22.002 -6.069  -44.346  1    42.041  ? 309  LEU B N     1 ? 
ATOM   7175  C  CA    . LEU B 1 309 ? -23.29  -6.132  -43.686  1    44.32   ? 309  LEU B CA    1 ? 
ATOM   7176  C  C     . LEU B 1 309 ? -24.112 -7.311  -44.208  1    47.374  ? 309  LEU B C     1 ? 
ATOM   7177  O  O     . LEU B 1 309 ? -24.845 -7.946  -43.444  1    48.298  ? 309  LEU B O     1 ? 
ATOM   7178  C  CB    . LEU B 1 309 ? -23.988 -4.807  -43.972  1    55.308  ? 309  LEU B CB    1 ? 
ATOM   7179  C  CG    . LEU B 1 309 ? -25.349 -4.626  -43.301  1    59.43   ? 309  LEU B CG    1 ? 
ATOM   7180  C  CD1   . LEU B 1 309 ? -25.148 -4.156  -41.864  1    67.496  ? 309  LEU B CD1   1 ? 
ATOM   7181  C  CD2   . LEU B 1 309 ? -26.164 -3.631  -44.108  1    61.019  ? 309  LEU B CD2   1 ? 
ATOM   7182  N  N     . LEU B 1 310 ? -24.037 -7.565  -45.522  1    41.648  ? 310  LEU B N     1 ? 
ATOM   7183  C  CA    . LEU B 1 310 ? -24.774 -8.67   -46.127  1    47.037  ? 310  LEU B CA    1 ? 
ATOM   7184  C  C     . LEU B 1 310 ? -24.177 -10.015 -45.702  1    40.17   ? 310  LEU B C     1 ? 
ATOM   7185  O  O     . LEU B 1 310 ? -24.909 -10.995 -45.539  1    41.036  ? 310  LEU B O     1 ? 
ATOM   7186  C  CB    . LEU B 1 310 ? -24.82  -8.574  -47.653  1    44.046  ? 310  LEU B CB    1 ? 
ATOM   7187  C  CG    . LEU B 1 310 ? -25.923 -7.685  -48.236  1    49.203  ? 310  LEU B CG    1 ? 
ATOM   7188  C  CD1   . LEU B 1 310 ? -25.511 -6.217  -48.169  1    40.053  ? 310  LEU B CD1   1 ? 
ATOM   7189  C  CD2   . LEU B 1 310 ? -26.259 -8.124  -49.661  1    46.594  ? 310  LEU B CD2   1 ? 
ATOM   7190  N  N     . TYR B 1 311 ? -22.842 -10.066 -45.614  1    42.776  ? 311  TYR B N     1 ? 
ATOM   7191  C  CA    . TYR B 1 311 ? -22.134 -11.253 -45.131  1    46.874  ? 311  TYR B CA    1 ? 
ATOM   7192  C  C     . TYR B 1 311 ? -22.517 -11.532 -43.678  1    55.58   ? 311  TYR B C     1 ? 
ATOM   7193  O  O     . TYR B 1 311 ? -22.935 -12.648 -43.332  1    58.81   ? 311  TYR B O     1 ? 
ATOM   7194  C  CB    . TYR B 1 311 ? -20.623 -11.076 -45.291  1    43.422  ? 311  TYR B CB    1 ? 
ATOM   7195  C  CG    . TYR B 1 311 ? -20.155 -10.842 -46.722  1    40.565  ? 311  TYR B CG    1 ? 
ATOM   7196  C  CD1   . TYR B 1 311 ? -20.941 -11.154 -47.829  1    43.318  ? 311  TYR B CD1   1 ? 
ATOM   7197  C  CD2   . TYR B 1 311 ? -18.894 -10.326 -46.96   1    46.149  ? 311  TYR B CD2   1 ? 
ATOM   7198  C  CE1   . TYR B 1 311 ? -20.489 -10.926 -49.121  1    42.446  ? 311  TYR B CE1   1 ? 
ATOM   7199  C  CE2   . TYR B 1 311 ? -18.425 -10.106 -48.242  1    46.233  ? 311  TYR B CE2   1 ? 
ATOM   7200  C  CZ    . TYR B 1 311 ? -19.227 -10.401 -49.327  1    43.121  ? 311  TYR B CZ    1 ? 
ATOM   7201  O  OH    . TYR B 1 311 ? -18.699 -10.142 -50.559  1    49.207  ? 311  TYR B OH    1 ? 
ATOM   7202  N  N     . GLY B 1 312 ? -22.421 -10.474 -42.857  1    56.122  ? 312  GLY B N     1 ? 
ATOM   7203  C  CA    . GLY B 1 312 ? -22.831 -10.52  -41.463  1    52.542  ? 312  GLY B CA    1 ? 
ATOM   7204  C  C     . GLY B 1 312 ? -24.217 -11.129 -41.3    1    47.19   ? 312  GLY B C     1 ? 
ATOM   7205  O  O     . GLY B 1 312 ? -24.419 -11.979 -40.436  1    55.114  ? 312  GLY B O     1 ? 
ATOM   7206  N  N     . THR B 1 313 ? -25.164 -10.727 -42.158  1    46.169  ? 313  THR B N     1 ? 
ATOM   7207  C  CA    . THR B 1 313 ? -26.565 -11.072 -41.945  1    43.353  ? 313  THR B CA    1 ? 
ATOM   7208  C  C     . THR B 1 313 ? -26.786 -12.505 -42.426  1    48.226  ? 313  THR B C     1 ? 
ATOM   7209  O  O     . THR B 1 313 ? -27.677 -13.219 -41.955  1    52.519  ? 313  THR B O     1 ? 
ATOM   7210  C  CB    . THR B 1 313 ? -27.468 -10.097 -42.706  1    45.868  ? 313  THR B CB    1 ? 
ATOM   7211  O  OG1   . THR B 1 313 ? -26.854 -8.81   -42.807  1    48.598  ? 313  THR B OG1   1 ? 
ATOM   7212  C  CG2   . THR B 1 313 ? -28.834 -9.957  -42.071  1    40.468  ? 313  THR B CG2   1 ? 
ATOM   7213  N  N     . TYR B 1 314 ? -25.96  -12.895 -43.394  1    43.629  ? 314  TYR B N     1 ? 
ATOM   7214  C  CA    . TYR B 1 314 ? -26.021 -14.222 -43.974  1    50.129  ? 314  TYR B CA    1 ? 
ATOM   7215  C  C     . TYR B 1 314 ? -25.569 -15.226 -42.909  1    51.174  ? 314  TYR B C     1 ? 
ATOM   7216  O  O     . TYR B 1 314 ? -26.246 -16.227 -42.663  1    45.173  ? 314  TYR B O     1 ? 
ATOM   7217  C  CB    . TYR B 1 314 ? -25.168 -14.235 -45.252  1    41.395  ? 314  TYR B CB    1 ? 
ATOM   7218  C  CG    . TYR B 1 314 ? -25.061 -15.594 -45.925  1    44.781  ? 314  TYR B CG    1 ? 
ATOM   7219  C  CD1   . TYR B 1 314 ? -26.103 -16.066 -46.708  1    43.388  ? 314  TYR B CD1   1 ? 
ATOM   7220  C  CD2   . TYR B 1 314 ? -23.936 -16.406 -45.761  1    50.664  ? 314  TYR B CD2   1 ? 
ATOM   7221  C  CE1   . TYR B 1 314 ? -26.031 -17.304 -47.315  1    47.871  ? 314  TYR B CE1   1 ? 
ATOM   7222  C  CE2   . TYR B 1 314 ? -23.85  -17.651 -46.365  1    47.003  ? 314  TYR B CE2   1 ? 
ATOM   7223  C  CZ    . TYR B 1 314 ? -24.906 -18.092 -47.144  1    48.459  ? 314  TYR B CZ    1 ? 
ATOM   7224  O  OH    . TYR B 1 314 ? -24.895 -19.3   -47.764  1    44.41   ? 314  TYR B OH    1 ? 
ATOM   7225  N  N     . VAL B 1 315 ? -24.429 -14.936 -42.27   1    55.334  ? 315  VAL B N     1 ? 
ATOM   7226  C  CA    . VAL B 1 315 ? -23.919 -15.829 -41.237  1    62.42   ? 315  VAL B CA    1 ? 
ATOM   7227  C  C     . VAL B 1 315 ? -24.991 -16.038 -40.169  1    61.613  ? 315  VAL B C     1 ? 
ATOM   7228  O  O     . VAL B 1 315 ? -25.298 -17.18  -39.824  1    57.212  ? 315  VAL B O     1 ? 
ATOM   7229  C  CB    . VAL B 1 315 ? -22.574 -15.393 -40.635  1    57.551  ? 315  VAL B CB    1 ? 
ATOM   7230  C  CG1   . VAL B 1 315 ? -22.161 -16.254 -39.444  1    54.48   ? 315  VAL B CG1   1 ? 
ATOM   7231  C  CG2   . VAL B 1 315 ? -21.494 -15.393 -41.699  1    50.667  ? 315  VAL B CG2   1 ? 
ATOM   7232  N  N     . THR B 1 316 ? -25.626 -14.937 -39.746  1    58.209  ? 316  THR B N     1 ? 
ATOM   7233  C  CA    . THR B 1 316 ? -26.599 -14.96  -38.664  1    54.439  ? 316  THR B CA    1 ? 
ATOM   7234  C  C     . THR B 1 316 ? -27.804 -15.821 -39.017  1    53.566  ? 316  THR B C     1 ? 
ATOM   7235  O  O     . THR B 1 316 ? -28.332 -16.526 -38.16   1    54.178  ? 316  THR B O     1 ? 
ATOM   7236  C  CB    . THR B 1 316 ? -27.036 -13.537 -38.327  1    61.999  ? 316  THR B CB    1 ? 
ATOM   7237  O  OG1   . THR B 1 316 ? -25.813 -12.943 -37.905  1    66.218  ? 316  THR B OG1   1 ? 
ATOM   7238  C  CG2   . THR B 1 316 ? -28.106 -13.493 -37.249  1    64.225  ? 316  THR B CG2   1 ? 
ATOM   7239  N  N     . ILE B 1 317 ? -28.277 -15.726 -40.262  1    51.183  ? 317  ILE B N     1 ? 
ATOM   7240  C  CA    . ILE B 1 317 ? -29.591 -16.277 -40.553  1    55.386  ? 317  ILE B CA    1 ? 
ATOM   7241  C  C     . ILE B 1 317 ? -29.515 -17.663 -41.205  1    49.592  ? 317  ILE B C     1 ? 
ATOM   7242  O  O     . ILE B 1 317 ? -30.485 -18.424 -41.143  1    47.438  ? 317  ILE B O     1 ? 
ATOM   7243  C  CB    . ILE B 1 317 ? -30.415 -15.288 -41.395  1    66.351  ? 317  ILE B CB    1 ? 
ATOM   7244  C  CG1   . ILE B 1 317 ? -31.882 -15.753 -41.497  1    64.095  ? 317  ILE B CG1   1 ? 
ATOM   7245  C  CG2   . ILE B 1 317 ? -29.754 -15.076 -42.762  1    57.506  ? 317  ILE B CG2   1 ? 
ATOM   7246  C  CD1   . ILE B 1 317 ? -32.845 -14.713 -42.035  1    68.614  ? 317  ILE B CD1   1 ? 
ATOM   7247  N  N     . LEU B 1 318 ? -28.386 -17.976 -41.858  1    48.307  ? 318  LEU B N     1 ? 
ATOM   7248  C  CA    . LEU B 1 318 ? -28.249 -19.226 -42.6    1    51.81   ? 318  LEU B CA    1 ? 
ATOM   7249  C  C     . LEU B 1 318 ? -28.742 -20.426 -41.783  1    55.854  ? 318  LEU B C     1 ? 
ATOM   7250  O  O     . LEU B 1 318 ? -29.443 -21.273 -42.338  1    61.871  ? 318  LEU B O     1 ? 
ATOM   7251  C  CB    . LEU B 1 318 ? -26.864 -19.458 -43.221  1    48.547  ? 318  LEU B CB    1 ? 
ATOM   7252  C  CG    . LEU B 1 318 ? -26.77  -20.616 -44.223  1    47.146  ? 318  LEU B CG    1 ? 
ATOM   7253  C  CD1   . LEU B 1 318 ? -27.733 -20.462 -45.398  1    46.461  ? 318  LEU B CD1   1 ? 
ATOM   7254  C  CD2   . LEU B 1 318 ? -25.341 -20.798 -44.723  1    44.799  ? 318  LEU B CD2   1 ? 
ATOM   7255  N  N     . PRO B 1 319 ? -28.407 -20.583 -40.472  1    54.013  ? 319  PRO B N     1 ? 
ATOM   7256  C  CA    . PRO B 1 319 ? -28.953 -21.706 -39.704  1    55.512  ? 319  PRO B CA    1 ? 
ATOM   7257  C  C     . PRO B 1 319 ? -30.473 -21.9   -39.674  1    62.242  ? 319  PRO B C     1 ? 
ATOM   7258  O  O     . PRO B 1 319 ? -30.961 -23.028 -39.802  1    57.147  ? 319  PRO B O     1 ? 
ATOM   7259  C  CB    . PRO B 1 319 ? -28.264 -21.6   -38.324  1    54.741  ? 319  PRO B CB    1 ? 
ATOM   7260  C  CG    . PRO B 1 319 ? -26.965 -20.859 -38.639  1    51.308  ? 319  PRO B CG    1 ? 
ATOM   7261  C  CD    . PRO B 1 319 ? -27.376 -19.845 -39.716  1    48.646  ? 319  PRO B CD    1 ? 
ATOM   7262  N  N     . GLU B 1 320 ? -31.233 -20.802 -39.6    1    61.796  ? 320  GLU B N     1 ? 
ATOM   7263  C  CA    . GLU B 1 320 ? -32.686 -20.939 -39.588  1    74.076  ? 320  GLU B CA    1 ? 
ATOM   7264  C  C     . GLU B 1 320 ? -33.255 -21.258 -40.976  1    67.485  ? 320  GLU B C     1 ? 
ATOM   7265  O  O     . GLU B 1 320 ? -34.439 -21.56  -41.1    1    69.807  ? 320  GLU B O     1 ? 
ATOM   7266  C  CB    . GLU B 1 320 ? -33.397 -19.791 -38.862  1    82.059  ? 320  GLU B CB    1 ? 
ATOM   7267  C  CG    . GLU B 1 320 ? -32.732 -18.425 -39.031  1    97.427  ? 320  GLU B CG    1 ? 
ATOM   7268  C  CD    . GLU B 1 320 ? -33.326 -17.246 -38.264  1    96.257  ? 320  GLU B CD    1 ? 
ATOM   7269  O  OE1   . GLU B 1 320 ? -34.518 -16.918 -38.49   1    87.391  ? 320  GLU B OE1   1 ? 
ATOM   7270  O  OE2   . GLU B 1 320 ? -32.585 -16.645 -37.447  1    89.786  ? 320  GLU B OE2   1 ? 
ATOM   7271  N  N     . LEU B 1 321 ? -32.415 -21.225 -42.019  1    72.949  ? 321  LEU B N     1 ? 
ATOM   7272  C  CA    . LEU B 1 321 ? -32.91  -21.31  -43.39   1    67.824  ? 321  LEU B CA    1 ? 
ATOM   7273  C  C     . LEU B 1 321 ? -33.093 -22.763 -43.834  1    70.346  ? 321  LEU B C     1 ? 
ATOM   7274  O  O     . LEU B 1 321 ? -34.027 -23.064 -44.587  1    64.613  ? 321  LEU B O     1 ? 
ATOM   7275  C  CB    . LEU B 1 321 ? -32.042 -20.523 -44.373  1    64.658  ? 321  LEU B CB    1 ? 
ATOM   7276  C  CG    . LEU B 1 321 ? -32.071 -18.994 -44.265  1    57.337  ? 321  LEU B CG    1 ? 
ATOM   7277  C  CD1   . LEU B 1 321 ? -31.285 -18.377 -45.416  1    55.984  ? 321  LEU B CD1   1 ? 
ATOM   7278  C  CD2   . LEU B 1 321 ? -33.487 -18.431 -44.229  1    61.759  ? 321  LEU B CD2   1 ? 
ATOM   7279  N  N     . GLY B 1 322 ? -32.172 -23.643 -43.409  1    64.05   ? 322  GLY B N     1 ? 
ATOM   7280  C  CA    . GLY B 1 322 ? -32.266 -25.069 -43.691  1    61.086  ? 322  GLY B CA    1 ? 
ATOM   7281  C  C     . GLY B 1 322 ? -31.54  -25.485 -44.975  1    59.5    ? 322  GLY B C     1 ? 
ATOM   7282  O  O     . GLY B 1 322 ? -31.624 -26.639 -45.384  1    59.15   ? 322  GLY B O     1 ? 
ATOM   7283  N  N     . GLY B 1 323 ? -30.825 -24.548 -45.61   1    59.535  ? 323  GLY B N     1 ? 
ATOM   7284  C  CA    . GLY B 1 323 ? -30.135 -24.805 -46.867  1    56.282  ? 323  GLY B CA    1 ? 
ATOM   7285  C  C     . GLY B 1 323 ? -29.699 -23.491 -47.509  1    52.858  ? 323  GLY B C     1 ? 
ATOM   7286  O  O     . GLY B 1 323 ? -29.961 -22.439 -46.943  1    52.281  ? 323  GLY B O     1 ? 
ATOM   7287  N  N     . TYR B 1 324 ? -29.062 -23.558 -48.685  1    49.244  ? 324  TYR B N     1 ? 
ATOM   7288  C  CA    . TYR B 1 324 ? -28.525 -22.371 -49.34   1    44.431  ? 324  TYR B CA    1 ? 
ATOM   7289  C  C     . TYR B 1 324 ? -29.622 -21.602 -50.092  1    40.015  ? 324  TYR B C     1 ? 
ATOM   7290  O  O     . TYR B 1 324 ? -30.721 -22.103 -50.325  1    42.432  ? 324  TYR B O     1 ? 
ATOM   7291  C  CB    . TYR B 1 324 ? -27.265 -22.718 -50.139  1    45.481  ? 324  TYR B CB    1 ? 
ATOM   7292  C  CG    . TYR B 1 324 ? -26.123 -23.368 -49.366  1    43.151  ? 324  TYR B CG    1 ? 
ATOM   7293  C  CD1   . TYR B 1 324 ? -26.101 -24.744 -49.143  1    45.213  ? 324  TYR B CD1   1 ? 
ATOM   7294  C  CD2   . TYR B 1 324 ? -25.058 -22.615 -48.882  1    43.161  ? 324  TYR B CD2   1 ? 
ATOM   7295  C  CE1   . TYR B 1 324 ? -25.064 -25.346 -48.441  1    46.661  ? 324  TYR B CE1   1 ? 
ATOM   7296  C  CE2   . TYR B 1 324 ? -24.014 -23.205 -48.185  1    48.146  ? 324  TYR B CE2   1 ? 
ATOM   7297  C  CZ    . TYR B 1 324 ? -24.014 -24.578 -47.964  1    49.553  ? 324  TYR B CZ    1 ? 
ATOM   7298  O  OH    . TYR B 1 324 ? -22.988 -25.175 -47.278  1    45.665  ? 324  TYR B OH    1 ? 
ATOM   7299  N  N     . ILE B 1 325 ? -29.333 -20.348 -50.454  1    39.919  ? 325  ILE B N     1 ? 
ATOM   7300  C  CA    . ILE B 1 325 ? -30.34  -19.49  -51.07   1    39.244  ? 325  ILE B CA    1 ? 
ATOM   7301  C  C     . ILE B 1 325 ? -30.252 -19.59  -52.593  1    40.871  ? 325  ILE B C     1 ? 
ATOM   7302  O  O     . ILE B 1 325 ? -31.268 -19.788 -53.26   1    41.456  ? 325  ILE B O     1 ? 
ATOM   7303  C  CB    . ILE B 1 325 ? -30.177 -18.027 -50.626  1    42.984  ? 325  ILE B CB    1 ? 
ATOM   7304  C  CG1   . ILE B 1 325 ? -30.15  -17.89  -49.086  1    37.008  ? 325  ILE B CG1   1 ? 
ATOM   7305  C  CG2   . ILE B 1 325 ? -31.3   -17.195 -51.245  1    36.132  ? 325  ILE B CG2   1 ? 
ATOM   7306  C  CD1   . ILE B 1 325 ? -29.519 -16.601 -48.589  1    33.382  ? 325  ILE B CD1   1 ? 
ATOM   7307  N  N     . ASN B 1 326 ? -29.029 -19.443 -53.122  1    37.188  ? 326  ASN B N     1 ? 
ATOM   7308  C  CA    . ASN B 1 326 ? -28.757 -19.571 -54.545  1    36.543  ? 326  ASN B CA    1 ? 
ATOM   7309  C  C     . ASN B 1 326 ? -28.303 -20.999 -54.814  1    33.691  ? 326  ASN B C     1 ? 
ATOM   7310  O  O     . ASN B 1 326 ? -27.113 -21.286 -54.716  1    40.494  ? 326  ASN B O     1 ? 
ATOM   7311  C  CB    . ASN B 1 326 ? -27.702 -18.579 -55.046  1    32.052  ? 326  ASN B CB    1 ? 
ATOM   7312  C  CG    . ASN B 1 326 ? -27.31  -18.8   -56.504  1    35.329  ? 326  ASN B CG    1 ? 
ATOM   7313  O  OD1   . ASN B 1 326 ? -28.073 -19.396 -57.273  1    36.339  ? 326  ASN B OD1   1 ? 
ATOM   7314  N  ND2   . ASN B 1 326 ? -26.122 -18.368 -56.916  1    34.972  ? 326  ASN B ND2   1 ? 
ATOM   7315  N  N     . GLU B 1 327 ? -29.254 -21.867 -55.184  1    37.195  ? 327  GLU B N     1 ? 
ATOM   7316  C  CA    . GLU B 1 327 ? -28.985 -23.289 -55.377  1    36.82   ? 327  GLU B CA    1 ? 
ATOM   7317  C  C     . GLU B 1 327 ? -28.597 -23.555 -56.832  1    37.85   ? 327  GLU B C     1 ? 
ATOM   7318  O  O     . GLU B 1 327 ? -29.444 -23.864 -57.676  1    38.529  ? 327  GLU B O     1 ? 
ATOM   7319  C  CB    . GLU B 1 327 ? -30.187 -24.13  -54.946  1    37.646  ? 327  GLU B CB    1 ? 
ATOM   7320  C  CG    . GLU B 1 327 ? -30.815 -23.684 -53.625  1    42.932  ? 327  GLU B CG    1 ? 
ATOM   7321  C  CD    . GLU B 1 327 ? -31.765 -24.678 -52.966  1    45.127  ? 327  GLU B CD    1 ? 
ATOM   7322  O  OE1   . GLU B 1 327 ? -32.999 -24.562 -53.14   1    43.93   ? 327  GLU B OE1   1 ? 
ATOM   7323  O  OE2   . GLU B 1 327 ? -31.26  -25.56  -52.235  1    49.121  ? 327  GLU B OE2   1 ? 
ATOM   7324  N  N     . SER B 1 328 ? -27.298 -23.393 -57.121  1    39.451  ? 328  SER B N     1 ? 
ATOM   7325  C  CA    . SER B 1 328 ? -26.756 -23.582 -58.458  1    41.391  ? 328  SER B CA    1 ? 
ATOM   7326  C  C     . SER B 1 328 ? -27.566 -22.785 -59.487  1    40.647  ? 328  SER B C     1 ? 
ATOM   7327  O  O     . SER B 1 328 ? -27.876 -23.283 -60.566  1    37.312  ? 328  SER B O     1 ? 
ATOM   7328  C  CB    . SER B 1 328 ? -26.663 -25.06  -58.827  1    46.978  ? 328  SER B CB    1 ? 
ATOM   7329  O  OG    . SER B 1 328 ? -25.911 -25.771 -57.849  1    61.352  ? 328  SER B OG    1 ? 
ATOM   7330  N  N     . GLY B 1 329 ? -27.904 -21.54  -59.136  1    40.551  ? 329  GLY B N     1 ? 
ATOM   7331  C  CA    . GLY B 1 329 ? -28.566 -20.636 -60.056  1    36.007  ? 329  GLY B CA    1 ? 
ATOM   7332  C  C     . GLY B 1 329 ? -30.072 -20.618 -59.866  1    41.184  ? 329  GLY B C     1 ? 
ATOM   7333  O  O     . GLY B 1 329 ? -30.74  -19.788 -60.478  1    44.915  ? 329  GLY B O     1 ? 
ATOM   7334  N  N     . HIS B 1 330 ? -30.606 -21.495 -59.004  1    40.814  ? 330  HIS B N     1 ? 
ATOM   7335  C  CA    . HIS B 1 330 ? -32.045 -21.487 -58.771  1    44.866  ? 330  HIS B CA    1 ? 
ATOM   7336  C  C     . HIS B 1 330 ? -32.292 -20.817 -57.428  1    48.91   ? 330  HIS B C     1 ? 
ATOM   7337  O  O     . HIS B 1 330 ? -31.854 -21.305 -56.385  1    48.472  ? 330  HIS B O     1 ? 
ATOM   7338  C  CB    . HIS B 1 330 ? -32.681 -22.888 -58.832  1    47.137  ? 330  HIS B CB    1 ? 
ATOM   7339  C  CG    . HIS B 1 330 ? -32.687 -23.519 -60.182  1    52.021  ? 330  HIS B CG    1 ? 
ATOM   7340  N  ND1   . HIS B 1 330 ? -31.601 -24.192 -60.709  1    58.054  ? 330  HIS B ND1   1 ? 
ATOM   7341  C  CD2   . HIS B 1 330 ? -33.643 -23.552 -61.13   1    53.857  ? 330  HIS B CD2   1 ? 
ATOM   7342  C  CE1   . HIS B 1 330 ? -31.903 -24.637 -61.93   1    54.018  ? 330  HIS B CE1   1 ? 
ATOM   7343  N  NE2   . HIS B 1 330 ? -33.137 -24.253 -62.205  1    55.231  ? 330  HIS B NE2   1 ? 
ATOM   7344  N  N     . LEU B 1 331 ? -33.002 -19.689 -57.482  1    43.03   ? 331  LEU B N     1 ? 
ATOM   7345  C  CA    . LEU B 1 331 ? -33.265 -18.91  -56.29   1    41.302  ? 331  LEU B CA    1 ? 
ATOM   7346  C  C     . LEU B 1 331 ? -34.326 -19.652 -55.489  1    45.278  ? 331  LEU B C     1 ? 
ATOM   7347  O  O     . LEU B 1 331 ? -35.427 -19.896 -55.987  1    42.864  ? 331  LEU B O     1 ? 
ATOM   7348  C  CB    . LEU B 1 331 ? -33.75  -17.508 -56.664  1    38.623  ? 331  LEU B CB    1 ? 
ATOM   7349  C  CG    . LEU B 1 331 ? -33.664 -16.439 -55.573  1    37.156  ? 331  LEU B CG    1 ? 
ATOM   7350  C  CD1   . LEU B 1 331 ? -32.249 -16.292 -55.032  1    35.547  ? 331  LEU B CD1   1 ? 
ATOM   7351  C  CD2   . LEU B 1 331 ? -34.131 -15.122 -56.132  1    40.831  ? 331  LEU B CD2   1 ? 
ATOM   7352  N  N     . ASN B 1 332 ? -33.973 -19.981 -54.245  1    49.028  ? 332  ASN B N     1 ? 
ATOM   7353  C  CA    . ASN B 1 332 ? -34.935 -20.512 -53.295  1    45.563  ? 332  ASN B CA    1 ? 
ATOM   7354  C  C     . ASN B 1 332 ? -35.73  -19.331 -52.744  1    42.863  ? 332  ASN B C     1 ? 
ATOM   7355  O  O     . ASN B 1 332 ? -35.194 -18.545 -51.974  1    45.673  ? 332  ASN B O     1 ? 
ATOM   7356  C  CB    . ASN B 1 332 ? -34.196 -21.25  -52.179  1    46.113  ? 332  ASN B CB    1 ? 
ATOM   7357  C  CG    . ASN B 1 332 ? -35.127 -22.051 -51.302  1    46.852  ? 332  ASN B CG    1 ? 
ATOM   7358  O  OD1   . ASN B 1 332 ? -35.968 -21.484 -50.594  1    51.884  ? 332  ASN B OD1   1 ? 
ATOM   7359  N  ND2   . ASN B 1 332 ? -35     -23.367 -51.356  1    51.205  ? 332  ASN B ND2   1 ? 
ATOM   7360  N  N     . LEU B 1 333 ? -37.002 -19.21  -53.132  1    42.712  ? 333  LEU B N     1 ? 
ATOM   7361  C  CA    . LEU B 1 333 ? -37.772 -18.005 -52.842  1    48.917  ? 333  LEU B CA    1 ? 
ATOM   7362  C  C     . LEU B 1 333 ? -38.092 -17.86  -51.346  1    50.212  ? 333  LEU B C     1 ? 
ATOM   7363  O  O     . LEU B 1 333 ? -37.998 -16.751 -50.82   1    42.837  ? 333  LEU B O     1 ? 
ATOM   7364  C  CB    . LEU B 1 333 ? -39.005 -17.876 -53.742  1    44.284  ? 333  LEU B CB    1 ? 
ATOM   7365  C  CG    . LEU B 1 333 ? -38.707 -17.751 -55.245  1    48.751  ? 333  LEU B CG    1 ? 
ATOM   7366  C  CD1   . LEU B 1 333 ? -39.945 -17.583 -56.108  1    44.776  ? 333  LEU B CD1   1 ? 
ATOM   7367  C  CD2   . LEU B 1 333 ? -37.715 -16.628 -55.53   1    45.521  ? 333  LEU B CD2   1 ? 
ATOM   7368  N  N     . PRO B 1 334 ? -38.502 -18.927 -50.609  1    50.411  ? 334  PRO B N     1 ? 
ATOM   7369  C  CA    . PRO B 1 334 ? -38.77  -18.81  -49.17   1    53.752  ? 334  PRO B CA    1 ? 
ATOM   7370  C  C     . PRO B 1 334 ? -37.526 -18.398 -48.384  1    51.222  ? 334  PRO B C     1 ? 
ATOM   7371  O  O     . PRO B 1 334 ? -37.56  -17.482 -47.555  1    54.42   ? 334  PRO B O     1 ? 
ATOM   7372  C  CB    . PRO B 1 334 ? -39.212 -20.249 -48.884  1    51.814  ? 334  PRO B CB    1 ? 
ATOM   7373  C  CG    . PRO B 1 334 ? -39.886 -20.644 -50.165  1    48.399  ? 334  PRO B CG    1 ? 
ATOM   7374  C  CD    . PRO B 1 334 ? -38.768 -20.286 -51.112  1    54.024  ? 334  PRO B CD    1 ? 
ATOM   7375  N  N     . ARG B 1 335 ? -36.417 -19.07  -48.702  1    45.385  ? 335  ARG B N     1 ? 
ATOM   7376  C  CA    . ARG B 1 335 ? -35.125 -18.748 -48.128  1    48.945  ? 335  ARG B CA    1 ? 
ATOM   7377  C  C     . ARG B 1 335 ? -34.789 -17.284 -48.395  1    52.845  ? 335  ARG B C     1 ? 
ATOM   7378  O  O     . ARG B 1 335 ? -34.494 -16.547 -47.455  1    52.021  ? 335  ARG B O     1 ? 
ATOM   7379  C  CB    . ARG B 1 335 ? -34.027 -19.687 -48.644  1    45.883  ? 335  ARG B CB    1 ? 
ATOM   7380  C  CG    . ARG B 1 335 ? -34.114 -21.028 -47.939  1    44.888  ? 335  ARG B CG    1 ? 
ATOM   7381  C  CD    . ARG B 1 335 ? -32.884 -21.85  -48.177  1    40.037  ? 335  ARG B CD    1 ? 
ATOM   7382  N  NE    . ARG B 1 335 ? -33.278 -23.215 -47.841  1    40.775  ? 335  ARG B NE    1 ? 
ATOM   7383  C  CZ    . ARG B 1 335 ? -33.114 -24.299 -48.587  1    45.416  ? 335  ARG B CZ    1 ? 
ATOM   7384  N  NH1   . ARG B 1 335 ? -32.341 -24.289 -49.656  1    43.27   ? 335  ARG B NH1   1 ? 
ATOM   7385  N  NH2   . ARG B 1 335 ? -33.706 -25.419 -48.22   1    46.461  ? 335  ARG B NH2   1 ? 
ATOM   7386  N  N     . PHE B 1 336 ? -34.834 -16.888 -49.681  1    49.062  ? 336  PHE B N     1 ? 
ATOM   7387  C  CA    . PHE B 1 336 ? -34.511 -15.531 -50.113  1    47.422  ? 336  PHE B CA    1 ? 
ATOM   7388  C  C     . PHE B 1 336 ? -35.363 -14.495 -49.369  1    40.05   ? 336  PHE B C     1 ? 
ATOM   7389  O  O     . PHE B 1 336 ? -34.844 -13.485 -48.936  1    39.447  ? 336  PHE B O     1 ? 
ATOM   7390  C  CB    . PHE B 1 336 ? -34.74  -15.323 -51.616  1    44.282  ? 336  PHE B CB    1 ? 
ATOM   7391  C  CG    . PHE B 1 336 ? -34.222 -14.001 -52.176  1    44.644  ? 336  PHE B CG    1 ? 
ATOM   7392  C  CD1   . PHE B 1 336 ? -32.885 -13.641 -52.046  1    41.363  ? 336  PHE B CD1   1 ? 
ATOM   7393  C  CD2   . PHE B 1 336 ? -35.074 -13.126 -52.85   1    51.69   ? 336  PHE B CD2   1 ? 
ATOM   7394  C  CE1   . PHE B 1 336 ? -32.406 -12.463 -52.602  1    44.93   ? 336  PHE B CE1   1 ? 
ATOM   7395  C  CE2   . PHE B 1 336 ? -34.595 -11.941 -53.397  1    49.046  ? 336  PHE B CE2   1 ? 
ATOM   7396  C  CZ    . PHE B 1 336 ? -33.264 -11.606 -53.268  1    48.01   ? 336  PHE B CZ    1 ? 
ATOM   7397  N  N     . GLU B 1 337 ? -36.673 -14.735 -49.237  1    46.547  ? 337  GLU B N     1 ? 
ATOM   7398  C  CA    . GLU B 1 337 ? -37.541 -13.778 -48.566  1    53.397  ? 337  GLU B CA    1 ? 
ATOM   7399  C  C     . GLU B 1 337 ? -37.099 -13.528 -47.115  1    57.761  ? 337  GLU B C     1 ? 
ATOM   7400  O  O     . GLU B 1 337 ? -37.197 -12.4   -46.64   1    60.446  ? 337  GLU B O     1 ? 
ATOM   7401  C  CB    . GLU B 1 337 ? -39.016 -14.167 -48.651  1    51.706  ? 337  GLU B CB    1 ? 
ATOM   7402  C  CG    . GLU B 1 337 ? -39.863 -13.32  -47.705  1    60.522  ? 337  GLU B CG    1 ? 
ATOM   7403  C  CD    . GLU B 1 337 ? -41.336 -13.088 -47.981  1    66.163  ? 337  GLU B CD    1 ? 
ATOM   7404  O  OE1   . GLU B 1 337 ? -41.943 -13.76  -48.846  1    74.013  ? 337  GLU B OE1   1 ? 
ATOM   7405  O  OE2   . GLU B 1 337 ? -41.876 -12.178 -47.314  1    76.858  ? 337  GLU B OE2   1 ? 
ATOM   7406  N  N     . LYS B 1 338 ? -36.626 -14.566 -46.406  1    57.685  ? 338  LYS B N     1 ? 
ATOM   7407  C  CA    . LYS B 1 338 ? -36.273 -14.408 -44.996  1    55.495  ? 338  LYS B CA    1 ? 
ATOM   7408  C  C     . LYS B 1 338 ? -34.979 -13.609 -44.861  1    51.518  ? 338  LYS B C     1 ? 
ATOM   7409  O  O     . LYS B 1 338 ? -34.843 -12.779 -43.96   1    49.05   ? 338  LYS B O     1 ? 
ATOM   7410  C  CB    . LYS B 1 338 ? -36.209 -15.739 -44.231  1    58.006  ? 338  LYS B CB    1 ? 
ATOM   7411  C  CG    . LYS B 1 338 ? -37.506 -16.549 -44.209  1    61.666  ? 338  LYS B CG    1 ? 
ATOM   7412  C  CD    . LYS B 1 338 ? -37.346 -17.985 -43.711  1    65.284  ? 338  LYS B CD    1 ? 
ATOM   7413  C  CE    . LYS B 1 338 ? -38.605 -18.799 -43.792  1    64.598  ? 338  LYS B CE    1 ? 
ATOM   7414  N  NZ    . LYS B 1 338 ? -38.388 -20.201 -43.419  1    63.208  ? 338  LYS B NZ    1 ? 
ATOM   7415  N  N     . TYR B 1 339 ? -34.039 -13.856 -45.782  1    50.081  ? 339  TYR B N     1 ? 
ATOM   7416  C  CA    . TYR B 1 339 ? -32.746 -13.186 -45.79   1    47.436  ? 339  TYR B CA    1 ? 
ATOM   7417  C  C     . TYR B 1 339 ? -32.939 -11.683 -45.998  1    53.135  ? 339  TYR B C     1 ? 
ATOM   7418  O  O     . TYR B 1 339 ? -32.316 -10.863 -45.332  1    45.121  ? 339  TYR B O     1 ? 
ATOM   7419  C  CB    . TYR B 1 339 ? -31.881 -13.747 -46.92   1    41.172  ? 339  TYR B CB    1 ? 
ATOM   7420  C  CG    . TYR B 1 339 ? -30.584 -12.968 -47.03   1    38.755  ? 339  TYR B CG    1 ? 
ATOM   7421  C  CD1   . TYR B 1 339 ? -29.604 -13.094 -46.051  1    39.241  ? 339  TYR B CD1   1 ? 
ATOM   7422  C  CD2   . TYR B 1 339 ? -30.332 -12.111 -48.095  1    39.899  ? 339  TYR B CD2   1 ? 
ATOM   7423  C  CE1   . TYR B 1 339 ? -28.421 -12.383 -46.119  1    33.427  ? 339  TYR B CE1   1 ? 
ATOM   7424  C  CE2   . TYR B 1 339 ? -29.143 -11.401 -48.181  1    39.564  ? 339  TYR B CE2   1 ? 
ATOM   7425  C  CZ    . TYR B 1 339 ? -28.192 -11.52  -47.175  1    39.965  ? 339  TYR B CZ    1 ? 
ATOM   7426  O  OH    . TYR B 1 339 ? -27.004 -10.83  -47.206  1    39.543  ? 339  TYR B OH    1 ? 
ATOM   7427  N  N     . LEU B 1 340 ? -33.806 -11.339 -46.953  1    49.013  ? 340  LEU B N     1 ? 
ATOM   7428  C  CA    . LEU B 1 340 ? -34.106 -9.959  -47.289  1    51.974  ? 340  LEU B CA    1 ? 
ATOM   7429  C  C     . LEU B 1 340 ? -34.757 -9.265  -46.099  1    51.752  ? 340  LEU B C     1 ? 
ATOM   7430  O  O     . LEU B 1 340 ? -34.284 -8.211  -45.686  1    59.865  ? 340  LEU B O     1 ? 
ATOM   7431  C  CB    . LEU B 1 340 ? -34.989 -9.906  -48.538  1    52.322  ? 340  LEU B CB    1 ? 
ATOM   7432  C  CG    . LEU B 1 340 ? -34.249 -10.047 -49.872  1    47.247  ? 340  LEU B CG    1 ? 
ATOM   7433  C  CD1   . LEU B 1 340 ? -35.198 -9.932  -51.044  1    49.361  ? 340  LEU B CD1   1 ? 
ATOM   7434  C  CD2   . LEU B 1 340 ? -33.173 -8.979  -49.927  1    50.572  ? 340  LEU B CD2   1 ? 
ATOM   7435  N  N     . VAL B 1 341 ? -35.826 -9.865  -45.562  1    54.368  ? 341  VAL B N     1 ? 
ATOM   7436  C  CA    . VAL B 1 341 ? -36.523 -9.341  -44.395  1    60.85   ? 341  VAL B CA    1 ? 
ATOM   7437  C  C     . VAL B 1 341 ? -35.512 -8.922  -43.318  1    65.763  ? 341  VAL B C     1 ? 
ATOM   7438  O  O     . VAL B 1 341 ? -35.558 -7.793  -42.823  1    62.438  ? 341  VAL B O     1 ? 
ATOM   7439  C  CB    . VAL B 1 341 ? -37.595 -10.334 -43.905  1    66.124  ? 341  VAL B CB    1 ? 
ATOM   7440  C  CG1   . VAL B 1 341 ? -37.979 -10.139 -42.438  1    69.507  ? 341  VAL B CG1   1 ? 
ATOM   7441  C  CG2   . VAL B 1 341 ? -38.828 -10.295 -44.805  1    59.156  ? 341  VAL B CG2   1 ? 
ATOM   7442  N  N     . LYS B 1 342 ? -34.547 -9.801  -43.016  1    63.487  ? 342  LYS B N     1 ? 
ATOM   7443  C  CA    . LYS B 1 342 ? -33.527 -9.509  -42.021  1    61.181  ? 342  LYS B CA    1 ? 
ATOM   7444  C  C     . LYS B 1 342 ? -32.588 -8.402  -42.503  1    63.189  ? 342  LYS B C     1 ? 
ATOM   7445  O  O     . LYS B 1 342 ? -32.256 -7.497  -41.744  1    71.465  ? 342  LYS B O     1 ? 
ATOM   7446  C  CB    . LYS B 1 342 ? -32.78  -10.783 -41.608  1    65.528  ? 342  LYS B CB    1 ? 
ATOM   7447  C  CG    . LYS B 1 342 ? -31.719 -10.593 -40.536  1    81.998  ? 342  LYS B CG    1 ? 
ATOM   7448  C  CD    . LYS B 1 342 ? -32.208 -10.019 -39.21   1    82.013  ? 342  LYS B CD    1 ? 
ATOM   7449  C  CE    . LYS B 1 342 ? -31.055 -9.783  -38.289  1    82.427  ? 342  LYS B CE    1 ? 
ATOM   7450  N  NZ    . LYS B 1 342 ? -31.479 -8.972  -37.147  1    81.215  ? 342  LYS B NZ    1 ? 
ATOM   7451  N  N     . LEU B 1 343 ? -32.173 -8.461  -43.773  1    54.134  ? 343  LEU B N     1 ? 
ATOM   7452  C  CA    . LEU B 1 343 ? -31.24  -7.486  -44.311  1    52.426  ? 343  LEU B CA    1 ? 
ATOM   7453  C  C     . LEU B 1 343 ? -31.859 -6.087  -44.361  1    58.756  ? 343  LEU B C     1 ? 
ATOM   7454  O  O     . LEU B 1 343 ? -31.125 -5.102  -44.345  1    61.27   ? 343  LEU B O     1 ? 
ATOM   7455  C  CB    . LEU B 1 343 ? -30.741 -7.922  -45.689  1    47.996  ? 343  LEU B CB    1 ? 
ATOM   7456  C  CG    . LEU B 1 343 ? -29.745 -6.96   -46.336  1    50.714  ? 343  LEU B CG    1 ? 
ATOM   7457  C  CD1   . LEU B 1 343 ? -28.396 -7.04   -45.621  1    53.282  ? 343  LEU B CD1   1 ? 
ATOM   7458  C  CD2   . LEU B 1 343 ? -29.609 -7.216  -47.829  1    47.642  ? 343  LEU B CD2   1 ? 
ATOM   7459  N  N     . SER B 1 344 ? -33.199 -6.018  -44.408  1    61.879  ? 344  SER B N     1 ? 
ATOM   7460  C  CA    . SER B 1 344 ? -33.991 -4.818  -44.66   1    67.128  ? 344  SER B CA    1 ? 
ATOM   7461  C  C     . SER B 1 344 ? -33.837 -3.755  -43.568  1    74.669  ? 344  SER B C     1 ? 
ATOM   7462  O  O     . SER B 1 344 ? -34.309 -2.624  -43.718  1    68.265  ? 344  SER B O     1 ? 
ATOM   7463  C  CB    . SER B 1 344 ? -35.44  -5.179  -44.793  1    69.346  ? 344  SER B CB    1 ? 
ATOM   7464  O  OG    . SER B 1 344 ? -35.64  -6.057  -45.888  1    79.977  ? 344  SER B OG    1 ? 
ATOM   7465  N  N     . ASP B 1 345 ? -33.212 -4.117  -42.448  1    75.765  ? 345  ASP B N     1 ? 
ATOM   7466  C  CA    . ASP B 1 345 ? -33.055 -3.156  -41.371  1    83.677  ? 345  ASP B CA    1 ? 
ATOM   7467  C  C     . ASP B 1 345 ? -32.263 -1.958  -41.882  1    74.803  ? 345  ASP B C     1 ? 
ATOM   7468  O  O     . ASP B 1 345 ? -32.523 -0.825  -41.486  1    82.184  ? 345  ASP B O     1 ? 
ATOM   7469  C  CB    . ASP B 1 345 ? -32.529 -3.823  -40.11   1    93.155  ? 345  ASP B CB    1 ? 
ATOM   7470  C  CG    . ASP B 1 345 ? -33.561 -4.668  -39.38   1    101.495 ? 345  ASP B CG    1 ? 
ATOM   7471  O  OD1   . ASP B 1 345 ? -34.774 -4.427  -39.6    1    97.176  ? 345  ASP B OD1   1 ? 
ATOM   7472  O  OD2   . ASP B 1 345 ? -33.144 -5.576  -38.627  1    105.473 ? 345  ASP B OD2   1 ? 
ATOM   7473  N  N     . PHE B 1 346 ? -31.343 -2.231  -42.81   1    64.807  ? 346  PHE B N     1 ? 
ATOM   7474  C  CA    . PHE B 1 346 ? -30.447 -1.24   -43.385  1    64.788  ? 346  PHE B CA    1 ? 
ATOM   7475  C  C     . PHE B 1 346 ? -31.193 0.047   -43.756  1    62.229  ? 346  PHE B C     1 ? 
ATOM   7476  O  O     . PHE B 1 346 ? -30.621 1.136   -43.65   1    56.635  ? 346  PHE B O     1 ? 
ATOM   7477  C  CB    . PHE B 1 346 ? -29.719 -1.891  -44.568  1    68.036  ? 346  PHE B CB    1 ? 
ATOM   7478  C  CG    . PHE B 1 346 ? -28.843 -0.914  -45.336  1    79.046  ? 346  PHE B CG    1 ? 
ATOM   7479  C  CD1   . PHE B 1 346 ? -27.568 -0.586  -44.878  1    81.623  ? 346  PHE B CD1   1 ? 
ATOM   7480  C  CD2   . PHE B 1 346 ? -29.305 -0.299  -46.496  1    87.233  ? 346  PHE B CD2   1 ? 
ATOM   7481  C  CE1   . PHE B 1 346 ? -26.769 0.314   -45.571  1    82.454  ? 346  PHE B CE1   1 ? 
ATOM   7482  C  CE2   . PHE B 1 346 ? -28.507 0.615   -47.177  1    97.753  ? 346  PHE B CE2   1 ? 
ATOM   7483  C  CZ    . PHE B 1 346 ? -27.239 0.917   -46.717  1    88.533  ? 346  PHE B CZ    1 ? 
ATOM   7484  N  N     . ASP B 1 347 ? -32.463 -0.078  -44.178  1    53.887  ? 347  ASP B N     1 ? 
ATOM   7485  C  CA    . ASP B 1 347 ? -33.203 1.038   -44.753  1    63.177  ? 347  ASP B CA    1 ? 
ATOM   7486  C  C     . ASP B 1 347 ? -33.603 2.05    -43.68   1    68.031  ? 347  ASP B C     1 ? 
ATOM   7487  O  O     . ASP B 1 347 ? -33.65  3.252   -43.945  1    65.642  ? 347  ASP B O     1 ? 
ATOM   7488  C  CB    . ASP B 1 347 ? -34.436 0.569   -45.516  1    63.289  ? 347  ASP B CB    1 ? 
ATOM   7489  C  CG    . ASP B 1 347 ? -34.182 -0.101  -46.86   1    60.078  ? 347  ASP B CG    1 ? 
ATOM   7490  O  OD1   . ASP B 1 347 ? -33.121 0.184   -47.473  1    61.023  ? 347  ASP B OD1   1 ? 
ATOM   7491  O  OD2   . ASP B 1 347 ? -35.033 -0.924  -47.262  1    52.658  ? 347  ASP B OD2   1 ? 
ATOM   7492  N  N     . ARG B 1 348 ? -33.935 1.544   -42.486  1    66.152  ? 348  ARG B N     1 ? 
ATOM   7493  C  CA    . ARG B 1 348 ? -34.355 2.383   -41.377  1    61.941  ? 348  ARG B CA    1 ? 
ATOM   7494  C  C     . ARG B 1 348 ? -33.126 3.034   -40.752  1    58.83   ? 348  ARG B C     1 ? 
ATOM   7495  O  O     . ARG B 1 348 ? -33.191 4.17    -40.294  1    56.78   ? 348  ARG B O     1 ? 
ATOM   7496  C  CB    . ARG B 1 348 ? -35.095 1.523   -40.359  1    67.168  ? 348  ARG B CB    1 ? 
ATOM   7497  C  CG    . ARG B 1 348 ? -36.212 0.781   -41.073  1    76.795  ? 348  ARG B CG    1 ? 
ATOM   7498  C  CD    . ARG B 1 348 ? -36.535 -0.497  -40.314  1    92.003  ? 348  ARG B CD    1 ? 
ATOM   7499  N  NE    . ARG B 1 348 ? -37.862 -1.006  -40.673  1    93.661  ? 348  ARG B NE    1 ? 
ATOM   7500  C  CZ    . ARG B 1 348 ? -38.998 -0.344  -40.475  1    94.672  ? 348  ARG B CZ    1 ? 
ATOM   7501  N  NH1   . ARG B 1 348 ? -38.991 0.857   -39.915  1    92.163  ? 348  ARG B NH1   1 ? 
ATOM   7502  N  NH2   . ARG B 1 348 ? -40.144 -0.892  -40.835  1    97.505  ? 348  ARG B NH2   1 ? 
ATOM   7503  N  N     . GLU B 1 349 ? -32.01  2.3     -40.744  1    56.204  ? 349  GLU B N     1 ? 
ATOM   7504  C  CA    . GLU B 1 349 ? -30.743 2.864   -40.314  1    57.582  ? 349  GLU B CA    1 ? 
ATOM   7505  C  C     . GLU B 1 349 ? -30.511 4.148   -41.105  1    58.194  ? 349  GLU B C     1 ? 
ATOM   7506  O  O     . GLU B 1 349 ? -30.164 5.178   -40.53   1    67.315  ? 349  GLU B O     1 ? 
ATOM   7507  C  CB    . GLU B 1 349 ? -29.588 1.873   -40.478  1    69.822  ? 349  GLU B CB    1 ? 
ATOM   7508  C  CG    . GLU B 1 349 ? -29.674 0.67    -39.539  1    87.266  ? 349  GLU B CG    1 ? 
ATOM   7509  C  CD    . GLU B 1 349 ? -29.502 1.073   -38.088  1    98.231  ? 349  GLU B CD    1 ? 
ATOM   7510  O  OE1   . GLU B 1 349 ? -28.375 1.503   -37.752  1    98.149  ? 349  GLU B OE1   1 ? 
ATOM   7511  O  OE2   . GLU B 1 349 ? -30.484 0.987   -37.311  1    97.13   ? 349  GLU B OE2   1 ? 
ATOM   7512  N  N     . HIS B 1 350 ? -30.729 4.067   -42.425  1    53.244  ? 350  HIS B N     1 ? 
ATOM   7513  C  CA    . HIS B 1 350 ? -30.555 5.208   -43.311  1    50.918  ? 350  HIS B CA    1 ? 
ATOM   7514  C  C     . HIS B 1 350 ? -31.681 6.214   -43.072  1    46.752  ? 350  HIS B C     1 ? 
ATOM   7515  O  O     . HIS B 1 350 ? -31.43  7.413   -42.992  1    50.214  ? 350  HIS B O     1 ? 
ATOM   7516  C  CB    . HIS B 1 350 ? -30.445 4.822   -44.798  1    48.673  ? 350  HIS B CB    1 ? 
ATOM   7517  C  CG    . HIS B 1 350 ? -30.332 6.061   -45.615  1    46.855  ? 350  HIS B CG    1 ? 
ATOM   7518  N  ND1   . HIS B 1 350 ? -29.116 6.645   -45.909  1    54.601  ? 350  HIS B ND1   1 ? 
ATOM   7519  C  CD2   . HIS B 1 350 ? -31.277 6.887   -46.104  1    50.54   ? 350  HIS B CD2   1 ? 
ATOM   7520  C  CE1   . HIS B 1 350 ? -29.327 7.774   -46.586  1    58.302  ? 350  HIS B CE1   1 ? 
ATOM   7521  N  NE2   . HIS B 1 350 ? -30.632 7.943   -46.717  1    56.398  ? 350  HIS B NE2   1 ? 
ATOM   7522  N  N     . PHE B 1 351 ? -32.922 5.735   -42.948  1    38.694  ? 351  PHE B N     1 ? 
ATOM   7523  C  CA    . PHE B 1 351 ? -34.003 6.684   -42.762  1    46.013  ? 351  PHE B CA    1 ? 
ATOM   7524  C  C     . PHE B 1 351 ? -33.744 7.539   -41.513  1    47.825  ? 351  PHE B C     1 ? 
ATOM   7525  O  O     . PHE B 1 351 ? -33.959 8.743   -41.529  1    38.771  ? 351  PHE B O     1 ? 
ATOM   7526  C  CB    . PHE B 1 351 ? -35.349 5.966   -42.68   1    46.546  ? 351  PHE B CB    1 ? 
ATOM   7527  C  CG    . PHE B 1 351 ? -36.496 6.95    -42.502  1    57.502  ? 351  PHE B CG    1 ? 
ATOM   7528  C  CD1   . PHE B 1 351 ? -36.533 8.141   -43.227  1    57.043  ? 351  PHE B CD1   1 ? 
ATOM   7529  C  CD2   . PHE B 1 351 ? -37.514 6.703   -41.582  1    64.017  ? 351  PHE B CD2   1 ? 
ATOM   7530  C  CE1   . PHE B 1 351 ? -37.569 9.048   -43.049  1    62.684  ? 351  PHE B CE1   1 ? 
ATOM   7531  C  CE2   . PHE B 1 351 ? -38.555 7.607   -41.412  1    62.63   ? 351  PHE B CE2   1 ? 
ATOM   7532  C  CZ    . PHE B 1 351 ? -38.584 8.773   -42.151  1    60.351  ? 351  PHE B CZ    1 ? 
ATOM   7533  N  N     . SER B 1 352 ? -33.268 6.909   -40.426  1    51.443  ? 352  SER B N     1 ? 
ATOM   7534  C  CA    . SER B 1 352 ? -33.122 7.56    -39.128  1    57.808  ? 352  SER B CA    1 ? 
ATOM   7535  C  C     . SER B 1 352 ? -32.248 8.815   -39.18   1    56.156  ? 352  SER B C     1 ? 
ATOM   7536  O  O     . SER B 1 352 ? -32.476 9.741   -38.405  1    54.055  ? 352  SER B O     1 ? 
ATOM   7537  C  CB    . SER B 1 352 ? -32.639 6.59    -38.068  1    59.296  ? 352  SER B CB    1 ? 
ATOM   7538  O  OG    . SER B 1 352 ? -33.719 5.774   -37.631  1    57.862  ? 352  SER B OG    1 ? 
ATOM   7539  N  N     . GLU B 1 353 ? -31.256 8.851   -40.085  1    51.36   ? 353  GLU B N     1 ? 
ATOM   7540  C  CA    . GLU B 1 353 ? -30.441 10.049  -40.244  1    61.588  ? 353  GLU B CA    1 ? 
ATOM   7541  C  C     . GLU B 1 353 ? -31.286 11.216  -40.766  1    56.423  ? 353  GLU B C     1 ? 
ATOM   7542  O  O     . GLU B 1 353 ? -30.919 12.375  -40.573  1    61.737  ? 353  GLU B O     1 ? 
ATOM   7543  C  CB    . GLU B 1 353 ? -29.221 9.838   -41.146  1    65.556  ? 353  GLU B CB    1 ? 
ATOM   7544  C  CG    . GLU B 1 353 ? -28.228 8.8     -40.627  1    74.983  ? 353  GLU B CG    1 ? 
ATOM   7545  C  CD    . GLU B 1 353 ? -27.314 9.238   -39.493  1    82.68   ? 353  GLU B CD    1 ? 
ATOM   7546  O  OE1   . GLU B 1 353 ? -27.477 10.364  -38.964  1    79.286  ? 353  GLU B OE1   1 ? 
ATOM   7547  O  OE2   . GLU B 1 353 ? -26.417 8.437   -39.146  1    84.652  ? 353  GLU B OE2   1 ? 
ATOM   7548  N  N     . VAL B 1 354 ? -32.397 10.898  -41.443  1    52.136  ? 354  VAL B N     1 ? 
ATOM   7549  C  CA    . VAL B 1 354 ? -33.248 11.871  -42.119  1    55.85   ? 354  VAL B CA    1 ? 
ATOM   7550  C  C     . VAL B 1 354 ? -34.367 12.292  -41.166  1    61.622  ? 354  VAL B C     1 ? 
ATOM   7551  O  O     . VAL B 1 354 ? -34.671 13.476  -41.041  1    66.783  ? 354  VAL B O     1 ? 
ATOM   7552  C  CB    . VAL B 1 354 ? -33.815 11.32   -43.448  1    59.622  ? 354  VAL B CB    1 ? 
ATOM   7553  C  CG1   . VAL B 1 354 ? -35.034 12.096  -43.925  1    61.673  ? 354  VAL B CG1   1 ? 
ATOM   7554  C  CG2   . VAL B 1 354 ? -32.767 11.295  -44.556  1    64.503  ? 354  VAL B CG2   1 ? 
ATOM   7555  N  N     . PHE B 1 355 ? -34.959 11.309  -40.482  1    65.323  ? 355  PHE B N     1 ? 
ATOM   7556  C  CA    . PHE B 1 355 ? -36.006 11.534  -39.494  1    71.912  ? 355  PHE B CA    1 ? 
ATOM   7557  C  C     . PHE B 1 355 ? -35.534 12.453  -38.361  1    65.94   ? 355  PHE B C     1 ? 
ATOM   7558  O  O     . PHE B 1 355 ? -36.321 13.243  -37.842  1    61.389  ? 355  PHE B O     1 ? 
ATOM   7559  C  CB    . PHE B 1 355 ? -36.434 10.152  -38.99   1    75.759  ? 355  PHE B CB    1 ? 
ATOM   7560  C  CG    . PHE B 1 355 ? -37.602 10.126  -38.014  1    81.637  ? 355  PHE B CG    1 ? 
ATOM   7561  C  CD1   . PHE B 1 355 ? -38.905 10.343  -38.462  1    83.297  ? 355  PHE B CD1   1 ? 
ATOM   7562  C  CD2   . PHE B 1 355 ? -37.395 9.845   -36.663  1    81.157  ? 355  PHE B CD2   1 ? 
ATOM   7563  C  CE1   . PHE B 1 355 ? -39.975 10.302  -37.576  1    91.916  ? 355  PHE B CE1   1 ? 
ATOM   7564  C  CE2   . PHE B 1 355 ? -38.466 9.799   -35.78   1    88.093  ? 355  PHE B CE2   1 ? 
ATOM   7565  C  CZ    . PHE B 1 355 ? -39.751 10.03   -36.238  1    96.047  ? 355  PHE B CZ    1 ? 
ATOM   7566  N  N     . VAL B 1 356 ? -34.259 12.326  -37.97   1    65.269  ? 356  VAL B N     1 ? 
ATOM   7567  C  CA    . VAL B 1 356 ? -33.654 13.145  -36.925  1    72.03   ? 356  VAL B CA    1 ? 
ATOM   7568  C  C     . VAL B 1 356 ? -33.813 14.631  -37.267  1    71.552  ? 356  VAL B C     1 ? 
ATOM   7569  O  O     . VAL B 1 356 ? -34.255 15.413  -36.426  1    66.598  ? 356  VAL B O     1 ? 
ATOM   7570  C  CB    . VAL B 1 356 ? -32.185 12.758  -36.632  1    65.953  ? 356  VAL B CB    1 ? 
ATOM   7571  C  CG1   . VAL B 1 356 ? -31.376 13.9    -36.017  1    63.961  ? 356  VAL B CG1   1 ? 
ATOM   7572  C  CG2   . VAL B 1 356 ? -32.091 11.506  -35.774  1    64.291  ? 356  VAL B CG2   1 ? 
ATOM   7573  N  N     . ASP B 1 357 ? -33.471 15.004  -38.51   1    70.094  ? 357  ASP B N     1 ? 
ATOM   7574  C  CA    . ASP B 1 357 ? -33.496 16.392  -38.95   1    76.667  ? 357  ASP B CA    1 ? 
ATOM   7575  C  C     . ASP B 1 357 ? -34.928 16.928  -38.932  1    82.615  ? 357  ASP B C     1 ? 
ATOM   7576  O  O     . ASP B 1 357 ? -35.135 18.13   -38.771  1    89.849  ? 357  ASP B O     1 ? 
ATOM   7577  C  CB    . ASP B 1 357 ? -32.829 16.576  -40.307  1    75.308  ? 357  ASP B CB    1 ? 
ATOM   7578  C  CG    . ASP B 1 357 ? -31.345 16.229  -40.41   1    78.19   ? 357  ASP B CG    1 ? 
ATOM   7579  O  OD1   . ASP B 1 357 ? -30.657 16.134  -39.356  1    76.827  ? 357  ASP B OD1   1 ? 
ATOM   7580  O  OD2   . ASP B 1 357 ? -30.885 16.029  -41.553  1    73.3    ? 357  ASP B OD2   1 ? 
ATOM   7581  N  N     . LEU B 1 358 ? -35.912 16.031  -39.077  1    79.408  ? 358  LEU B N     1 ? 
ATOM   7582  C  CA    . LEU B 1 358 ? -37.3   16.449  -39.208  1    81.816  ? 358  LEU B CA    1 ? 
ATOM   7583  C  C     . LEU B 1 358 ? -37.86  16.954  -37.876  1    81.198  ? 358  LEU B C     1 ? 
ATOM   7584  O  O     . LEU B 1 358 ? -38.711 17.837  -37.881  1    77.113  ? 358  LEU B O     1 ? 
ATOM   7585  C  CB    . LEU B 1 358 ? -38.178 15.384  -39.866  1    77.519  ? 358  LEU B CB    1 ? 
ATOM   7586  C  CG    . LEU B 1 358 ? -37.809 15.027  -41.311  1    77.601  ? 358  LEU B CG    1 ? 
ATOM   7587  C  CD1   . LEU B 1 358 ? -38.7   13.925  -41.834  1    80.994  ? 358  LEU B CD1   1 ? 
ATOM   7588  C  CD2   . LEU B 1 358 ? -37.818 16.222  -42.259  1    73.366  ? 358  LEU B CD2   1 ? 
ATOM   7589  N  N     . LYS B 1 359 ? -37.358 16.421  -36.749  1    82.915  ? 359  LYS B N     1 ? 
ATOM   7590  C  CA    . LYS B 1 359 ? -37.817 16.804  -35.417  1    95.561  ? 359  LYS B CA    1 ? 
ATOM   7591  C  C     . LYS B 1 359 ? -37.578 18.295  -35.173  1    95.173  ? 359  LYS B C     1 ? 
ATOM   7592  O  O     . LYS B 1 359 ? -38.302 18.91   -34.391  1    99.965  ? 359  LYS B O     1 ? 
ATOM   7593  C  CB    . LYS B 1 359 ? -37.136 16.041  -34.271  1    95.227  ? 359  LYS B CB    1 ? 
ATOM   7594  C  CG    . LYS B 1 359 ? -36.97  14.532  -34.424  1    96.287  ? 359  LYS B CG    1 ? 
ATOM   7595  C  CD    . LYS B 1 359 ? -36.276 13.883  -33.232  1    92.887  ? 359  LYS B CD    1 ? 
ATOM   7596  C  CE    . LYS B 1 359 ? -37.198 13.301  -32.207  1    88.257  ? 359  LYS B CE    1 ? 
ATOM   7597  N  NZ    . LYS B 1 359 ? -37.66  11.987  -32.666  1    80.709  ? 359  LYS B NZ    1 ? 
ATOM   7598  N  N     . TRP B 1 360 ? -36.544 18.848  -35.83   1    93.762  ? 360  TRP B N     1 ? 
ATOM   7599  C  CA    . TRP B 1 360 ? -36.192 20.263  -35.784  1    87.051  ? 360  TRP B CA    1 ? 
ATOM   7600  C  C     . TRP B 1 360 ? -36.18  20.874  -37.197  1    80.054  ? 360  TRP B C     1 ? 
ATOM   7601  O  O     . TRP B 1 360 ? -37.265 20.989  -37.82   1    83.935  ? 360  TRP B O     1 ? 
ATOM   7602  C  CB    . TRP B 1 360 ? -34.844 20.479  -35.071  1    80.701  ? 360  TRP B CB    1 ? 
ATOM   7603  C  CG    . TRP B 1 360 ? -33.66  19.717  -35.62   1    76.406  ? 360  TRP B CG    1 ? 
ATOM   7604  C  CD1   . TRP B 1 360 ? -33.182 18.521  -35.165  1    74.834  ? 360  TRP B CD1   1 ? 
ATOM   7605  C  CD2   . TRP B 1 360 ? -32.784 20.101  -36.708  1    73.466  ? 360  TRP B CD2   1 ? 
ATOM   7606  N  NE1   . TRP B 1 360 ? -32.079 18.133  -35.883  1    73.588  ? 360  TRP B NE1   1 ? 
ATOM   7607  C  CE2   . TRP B 1 360 ? -31.812 19.077  -36.838  1    72.898  ? 360  TRP B CE2   1 ? 
ATOM   7608  C  CE3   . TRP B 1 360 ? -32.729 21.193  -37.587  1    72.485  ? 360  TRP B CE3   1 ? 
ATOM   7609  C  CZ2   . TRP B 1 360 ? -30.806 19.116  -37.805  1    69.972  ? 360  TRP B CZ2   1 ? 
ATOM   7610  C  CZ3   . TRP B 1 360 ? -31.735 21.23   -38.547  1    71.92   ? 360  TRP B CZ3   1 ? 
ATOM   7611  C  CH2   . TRP B 1 360 ? -30.787 20.206  -38.65   1    72.998  ? 360  TRP B CH2   1 ? 
ATOM   7612  N  N     . LEU B 1 425 ? -44.381 6.866   -34.321  1    86.112  ? 425  LEU B N     1 ? 
ATOM   7613  C  CA    . LEU B 1 425 ? -45.105 7.266   -35.56   1    95.888  ? 425  LEU B CA    1 ? 
ATOM   7614  C  C     . LEU B 1 425 ? -44.229 6.95    -36.769  1    105.314 ? 425  LEU B C     1 ? 
ATOM   7615  O  O     . LEU B 1 425 ? -44.685 7.022   -37.909  1    119.427 ? 425  LEU B O     1 ? 
ATOM   7616  C  CB    . LEU B 1 425 ? -45.506 8.745   -35.535  1    98.135  ? 425  LEU B CB    1 ? 
ATOM   7617  C  CG    . LEU B 1 425 ? -44.406 9.785   -35.809  1    99.264  ? 425  LEU B CG    1 ? 
ATOM   7618  C  CD1   . LEU B 1 425 ? -45.022 11.119  -36.205  1    93.983  ? 425  LEU B CD1   1 ? 
ATOM   7619  C  CD2   . LEU B 1 425 ? -43.42  9.986   -34.658  1    91.116  ? 425  LEU B CD2   1 ? 
ATOM   7620  N  N     . PHE B 1 426 ? -42.968 6.607   -36.48   1    97.46   ? 426  PHE B N     1 ? 
ATOM   7621  C  CA    . PHE B 1 426 ? -41.904 6.348   -37.438  1    95.587  ? 426  PHE B CA    1 ? 
ATOM   7622  C  C     . PHE B 1 426 ? -42.463 5.787   -38.745  1    95.17   ? 426  PHE B C     1 ? 
ATOM   7623  O  O     . PHE B 1 426 ? -42.092 6.256   -39.815  1    99.483  ? 426  PHE B O     1 ? 
ATOM   7624  C  CB    . PHE B 1 426 ? -40.898 5.435   -36.723  1    94.191  ? 426  PHE B CB    1 ? 
ATOM   7625  C  CG    . PHE B 1 426 ? -39.503 5.303   -37.324  1    94.562  ? 426  PHE B CG    1 ? 
ATOM   7626  C  CD1   . PHE B 1 426 ? -38.587 6.347   -37.244  1    95.397  ? 426  PHE B CD1   1 ? 
ATOM   7627  C  CD2   . PHE B 1 426 ? -39.087 4.115   -37.922  1    93.763  ? 426  PHE B CD2   1 ? 
ATOM   7628  C  CE1   . PHE B 1 426 ? -37.313 6.221   -37.785  1    95.961  ? 426  PHE B CE1   1 ? 
ATOM   7629  C  CE2   . PHE B 1 426 ? -37.81  3.992   -38.456  1    91.482  ? 426  PHE B CE2   1 ? 
ATOM   7630  C  CZ    . PHE B 1 426 ? -36.926 5.046   -38.391  1    91.103  ? 426  PHE B CZ    1 ? 
ATOM   7631  N  N     . GLU B 1 427 ? -43.362 4.797   -38.645  1    92.492  ? 427  GLU B N     1 ? 
ATOM   7632  C  CA    . GLU B 1 427 ? -43.881 4.065   -39.791  1    94.355  ? 427  GLU B CA    1 ? 
ATOM   7633  C  C     . GLU B 1 427 ? -44.461 5.012   -40.834  1    104.129 ? 427  GLU B C     1 ? 
ATOM   7634  O  O     . GLU B 1 427 ? -44.091 4.926   -42.004  1    108.504 ? 427  GLU B O     1 ? 
ATOM   7635  C  CB    . GLU B 1 427 ? -44.94  3.035   -39.401  1    95.986  ? 427  GLU B CB    1 ? 
ATOM   7636  C  CG    . GLU B 1 427 ? -44.364 1.865   -38.613  1    94.889  ? 427  GLU B CG    1 ? 
ATOM   7637  C  CD    . GLU B 1 427 ? -43.093 1.306   -39.226  1    95.546  ? 427  GLU B CD    1 ? 
ATOM   7638  O  OE1   . GLU B 1 427 ? -43.173 0.221   -39.839  1    91.783  ? 427  GLU B OE1   1 ? 
ATOM   7639  O  OE2   . GLU B 1 427 ? -42.029 1.949   -39.088  1    92.667  ? 427  GLU B OE2   1 ? 
ATOM   7640  N  N     . THR B 1 428 ? -45.372 5.892   -40.393  1    113.143 ? 428  THR B N     1 ? 
ATOM   7641  C  CA    . THR B 1 428 ? -46.007 6.879   -41.255  1    118.575 ? 428  THR B CA    1 ? 
ATOM   7642  C  C     . THR B 1 428 ? -44.928 7.692   -41.97   1    117.905 ? 428  THR B C     1 ? 
ATOM   7643  O  O     . THR B 1 428 ? -45.104 8.079   -43.126  1    115.669 ? 428  THR B O     1 ? 
ATOM   7644  C  CB    . THR B 1 428 ? -46.97  7.761   -40.453  1    114.778 ? 428  THR B CB    1 ? 
ATOM   7645  O  OG1   . THR B 1 428 ? -48.034 6.894   -40.072  1    113.578 ? 428  THR B OG1   1 ? 
ATOM   7646  C  CG2   . THR B 1 428 ? -47.565 8.905   -41.258  1    104.712 ? 428  THR B CG2   1 ? 
ATOM   7647  N  N     . GLU B 1 429 ? -43.803 7.922   -41.281  1    105.179 ? 429  GLU B N     1 ? 
ATOM   7648  C  CA    . GLU B 1 429 ? -42.774 8.806   -41.806  1    97.919  ? 429  GLU B CA    1 ? 
ATOM   7649  C  C     . GLU B 1 429 ? -41.832 8.031   -42.729  1    87.772  ? 429  GLU B C     1 ? 
ATOM   7650  O  O     . GLU B 1 429 ? -41.353 8.581   -43.717  1    81.837  ? 429  GLU B O     1 ? 
ATOM   7651  C  CB    . GLU B 1 429 ? -42.111 9.623   -40.696  1    96.191  ? 429  GLU B CB    1 ? 
ATOM   7652  C  CG    . GLU B 1 429 ? -41.522 10.936  -41.21   1    107.747 ? 429  GLU B CG    1 ? 
ATOM   7653  C  CD    . GLU B 1 429 ? -42.491 11.864  -41.932  1    110.477 ? 429  GLU B CD    1 ? 
ATOM   7654  O  OE1   . GLU B 1 429 ? -42.331 12.095  -43.154  1    112.145 ? 429  GLU B OE1   1 ? 
ATOM   7655  O  OE2   . GLU B 1 429 ? -43.419 12.36   -41.261  1    116.204 ? 429  GLU B OE2   1 ? 
ATOM   7656  N  N     . PHE B 1 430 ? -41.604 6.747   -42.417  1    90.002  ? 430  PHE B N     1 ? 
ATOM   7657  C  CA    . PHE B 1 430 ? -40.724 5.891   -43.2    1    84.41   ? 430  PHE B CA    1 ? 
ATOM   7658  C  C     . PHE B 1 430 ? -41.375 5.542   -44.535  1    87.542  ? 430  PHE B C     1 ? 
ATOM   7659  O  O     . PHE B 1 430 ? -40.699 5.585   -45.562  1    84.642  ? 430  PHE B O     1 ? 
ATOM   7660  C  CB    . PHE B 1 430 ? -40.361 4.579   -42.502  1    72.732  ? 430  PHE B CB    1 ? 
ATOM   7661  C  CG    . PHE B 1 430 ? -39.328 3.729   -43.23   1    70.477  ? 430  PHE B CG    1 ? 
ATOM   7662  C  CD1   . PHE B 1 430 ? -38.185 4.298   -43.788  1    75.717  ? 430  PHE B CD1   1 ? 
ATOM   7663  C  CD2   . PHE B 1 430 ? -39.494 2.355   -43.353  1    64.811  ? 430  PHE B CD2   1 ? 
ATOM   7664  C  CE1   . PHE B 1 430 ? -37.235 3.516   -44.438  1    71.75   ? 430  PHE B CE1   1 ? 
ATOM   7665  C  CE2   . PHE B 1 430 ? -38.541 1.578   -44.002  1    70.569  ? 430  PHE B CE2   1 ? 
ATOM   7666  C  CZ    . PHE B 1 430 ? -37.415 2.158   -44.545  1    68.271  ? 430  PHE B CZ    1 ? 
ATOM   7667  N  N     . ARG B 1 431 ? -42.668 5.175   -44.493  1    83.949  ? 431  ARG B N     1 ? 
ATOM   7668  C  CA    . ARG B 1 431 ? -43.445 4.826   -45.677  1    84.403  ? 431  ARG B CA    1 ? 
ATOM   7669  C  C     . ARG B 1 431 ? -43.614 6.033   -46.603  1    85.848  ? 431  ARG B C     1 ? 
ATOM   7670  O  O     . ARG B 1 431 ? -43.512 5.888   -47.822  1    88.975  ? 431  ARG B O     1 ? 
ATOM   7671  C  CB    . ARG B 1 431 ? -44.748 4.117   -45.295  1    85.869  ? 431  ARG B CB    1 ? 
ATOM   7672  C  CG    . ARG B 1 431 ? -44.585 2.604   -45.382  1    100.923 ? 431  ARG B CG    1 ? 
ATOM   7673  C  CD    . ARG B 1 431 ? -45.553 1.758   -44.554  1    115.569 ? 431  ARG B CD    1 ? 
ATOM   7674  N  NE    . ARG B 1 431 ? -46.945 2.225   -44.569  1    122.283 ? 431  ARG B NE    1 ? 
ATOM   7675  C  CZ    . ARG B 1 431 ? -47.685 2.474   -43.492  1    121.671 ? 431  ARG B CZ    1 ? 
ATOM   7676  N  NH1   . ARG B 1 431 ? -47.231 2.183   -42.282  1    112.616 ? 431  ARG B NH1   1 ? 
ATOM   7677  N  NH2   . ARG B 1 431 ? -48.89  2.999   -43.636  1    118.861 ? 431  ARG B NH2   1 ? 
ATOM   7678  N  N     . GLN B 1 432 ? -43.844 7.218   -46.019  1    84.982  ? 432  GLN B N     1 ? 
ATOM   7679  C  CA    . GLN B 1 432 ? -43.961 8.459   -46.775  1    86.63   ? 432  GLN B CA    1 ? 
ATOM   7680  C  C     . GLN B 1 432 ? -42.572 8.942   -47.195  1    76.942  ? 432  GLN B C     1 ? 
ATOM   7681  O  O     . GLN B 1 432 ? -42.447 9.824   -48.04   1    75.753  ? 432  GLN B O     1 ? 
ATOM   7682  C  CB    . GLN B 1 432 ? -44.74  9.546   -46.026  1    98.15   ? 432  GLN B CB    1 ? 
ATOM   7683  C  CG    . GLN B 1 432 ? -46.234 9.265   -45.865  1    115.934 ? 432  GLN B CG    1 ? 
ATOM   7684  C  CD    . GLN B 1 432 ? -47.097 9.714   -47.028  1    125.044 ? 432  GLN B CD    1 ? 
ATOM   7685  O  OE1   . GLN B 1 432 ? -46.831 9.409   -48.197  1    117.852 ? 432  GLN B OE1   1 ? 
ATOM   7686  N  NE2   . GLN B 1 432 ? -48.159 10.443  -46.713  1    127.588 ? 432  GLN B NE2   1 ? 
ATOM   7687  N  N     . TYR B 1 433 ? -41.528 8.372   -46.586  1    69.888  ? 433  TYR B N     1 ? 
ATOM   7688  C  CA    . TYR B 1 433 ? -40.172 8.569   -47.075  1    61.207  ? 433  TYR B CA    1 ? 
ATOM   7689  C  C     . TYR B 1 433 ? -39.998 7.759   -48.356  1    63.999  ? 433  TYR B C     1 ? 
ATOM   7690  O  O     . TYR B 1 433 ? -39.518 8.292   -49.353  1    68.977  ? 433  TYR B O     1 ? 
ATOM   7691  C  CB    . TYR B 1 433 ? -39.114 8.23    -46.021  1    66.307  ? 433  TYR B CB    1 ? 
ATOM   7692  C  CG    . TYR B 1 433 ? -37.697 8.12    -46.564  1    64.872  ? 433  TYR B CG    1 ? 
ATOM   7693  C  CD1   . TYR B 1 433 ? -37.032 9.236   -47.064  1    65.419  ? 433  TYR B CD1   1 ? 
ATOM   7694  C  CD2   . TYR B 1 433 ? -37.017 6.906   -46.555  1    70.593  ? 433  TYR B CD2   1 ? 
ATOM   7695  C  CE1   . TYR B 1 433 ? -35.746 9.148   -47.568  1    70.799  ? 433  TYR B CE1   1 ? 
ATOM   7696  C  CE2   . TYR B 1 433 ? -35.724 6.806   -47.051  1    78.117  ? 433  TYR B CE2   1 ? 
ATOM   7697  C  CZ    . TYR B 1 433 ? -35.089 7.929   -47.56   1    81.345  ? 433  TYR B CZ    1 ? 
ATOM   7698  O  OH    . TYR B 1 433 ? -33.814 7.845   -48.051  1    88.708  ? 433  TYR B OH    1 ? 
ATOM   7699  N  N     . LYS B 1 434 ? -40.416 6.484   -48.319  1    65.048  ? 434  LYS B N     1 ? 
ATOM   7700  C  CA    . LYS B 1 434 ? -40.321 5.574   -49.453  1    65.307  ? 434  LYS B CA    1 ? 
ATOM   7701  C  C     . LYS B 1 434 ? -41.203 6.063   -50.599  1    70.342  ? 434  LYS B C     1 ? 
ATOM   7702  O  O     . LYS B 1 434 ? -40.714 6.227   -51.72   1    67.106  ? 434  LYS B O     1 ? 
ATOM   7703  C  CB    . LYS B 1 434 ? -40.729 4.148   -49.079  1    57.523  ? 434  LYS B CB    1 ? 
ATOM   7704  C  CG    . LYS B 1 434 ? -39.735 3.36    -48.259  1    64.962  ? 434  LYS B CG    1 ? 
ATOM   7705  C  CD    . LYS B 1 434 ? -40.572 2.391   -47.435  1    69.025  ? 434  LYS B CD    1 ? 
ATOM   7706  C  CE    . LYS B 1 434 ? -39.842 1.15    -47.082  1    70.669  ? 434  LYS B CE    1 ? 
ATOM   7707  N  NZ    . LYS B 1 434 ? -40.707 0.294   -46.269  1    71.57   ? 434  LYS B NZ    1 ? 
ATOM   7708  N  N     . ARG B 1 435 ? -42.493 6.285   -50.299  1    70.452  ? 435  ARG B N     1 ? 
ATOM   7709  C  CA    . ARG B 1 435 ? -43.476 6.772   -51.26   1    74.485  ? 435  ARG B CA    1 ? 
ATOM   7710  C  C     . ARG B 1 435 ? -42.904 7.933   -52.08   1    64.633  ? 435  ARG B C     1 ? 
ATOM   7711  O  O     . ARG B 1 435 ? -42.983 7.932   -53.311  1    60.728  ? 435  ARG B O     1 ? 
ATOM   7712  C  CB    . ARG B 1 435 ? -44.801 7.064   -50.538  1    79.651  ? 435  ARG B CB    1 ? 
ATOM   7713  C  CG    . ARG B 1 435 ? -45.946 7.74    -51.281  1    90.038  ? 435  ARG B CG    1 ? 
ATOM   7714  C  CD    . ARG B 1 435 ? -47.304 7.498   -50.611  1    94.564  ? 435  ARG B CD    1 ? 
ATOM   7715  N  NE    . ARG B 1 435 ? -48.293 8.562   -50.836  1    99.294  ? 435  ARG B NE    1 ? 
ATOM   7716  C  CZ    . ARG B 1 435 ? -49.606 8.505   -50.597  1    91.766  ? 435  ARG B CZ    1 ? 
ATOM   7717  N  NH1   . ARG B 1 435 ? -50.179 7.373   -50.217  1    80.32   ? 435  ARG B NH1   1 ? 
ATOM   7718  N  NH2   . ARG B 1 435 ? -50.35  9.583   -50.775  1    89.315  ? 435  ARG B NH2   1 ? 
ATOM   7719  N  N     . THR B 1 436 ? -42.292 8.906   -51.399  1    66.119  ? 436  THR B N     1 ? 
ATOM   7720  C  CA    . THR B 1 436 ? -41.775 10.1    -52.058  1    67.243  ? 436  THR B CA    1 ? 
ATOM   7721  C  C     . THR B 1 436 ? -40.72  9.723   -53.104  1    68.755  ? 436  THR B C     1 ? 
ATOM   7722  O  O     . THR B 1 436 ? -40.583 10.406  -54.119  1    72.184  ? 436  THR B O     1 ? 
ATOM   7723  C  CB    . THR B 1 436 ? -41.252 11.112  -51.028  1    71.395  ? 436  THR B CB    1 ? 
ATOM   7724  O  OG1   . THR B 1 436 ? -42.326 11.501  -50.176  1    66.903  ? 436  THR B OG1   1 ? 
ATOM   7725  C  CG2   . THR B 1 436 ? -40.669 12.37   -51.654  1    78.852  ? 436  THR B CG2   1 ? 
ATOM   7726  N  N     . TYR B 1 437 ? -39.963 8.645   -52.86   1    70.079  ? 437  TYR B N     1 ? 
ATOM   7727  C  CA    . TYR B 1 437 ? -38.905 8.255   -53.787  1    80.294  ? 437  TYR B CA    1 ? 
ATOM   7728  C  C     . TYR B 1 437 ? -39.499 7.563   -55.02   1    81.491  ? 437  TYR B C     1 ? 
ATOM   7729  O  O     . TYR B 1 437 ? -39.062 7.81    -56.15   1    69.857  ? 437  TYR B O     1 ? 
ATOM   7730  C  CB    . TYR B 1 437 ? -37.781 7.452   -53.117  1    78.237  ? 437  TYR B CB    1 ? 
ATOM   7731  C  CG    . TYR B 1 437 ? -36.543 8.23    -52.682  1    78.352  ? 437  TYR B CG    1 ? 
ATOM   7732  C  CD1   . TYR B 1 437 ? -35.615 8.679   -53.617  1    77.345  ? 437  TYR B CD1   1 ? 
ATOM   7733  C  CD2   . TYR B 1 437 ? -36.279 8.478   -51.336  1    78.26   ? 437  TYR B CD2   1 ? 
ATOM   7734  C  CE1   . TYR B 1 437 ? -34.477 9.368   -53.228  1    83.298  ? 437  TYR B CE1   1 ? 
ATOM   7735  C  CE2   . TYR B 1 437 ? -35.142 9.163   -50.935  1    78.039  ? 437  TYR B CE2   1 ? 
ATOM   7736  C  CZ    . TYR B 1 437 ? -34.238 9.606   -51.885  1    79.64   ? 437  TYR B CZ    1 ? 
ATOM   7737  O  OH    . TYR B 1 437 ? -33.113 10.273  -51.5    1    92.712  ? 437  TYR B OH    1 ? 
ATOM   7738  N  N     . TYR B 1 438 ? -40.498 6.699   -54.775  1    81.833  ? 438  TYR B N     1 ? 
ATOM   7739  C  CA    . TYR B 1 438 ? -41.19  5.933   -55.801  1    82.991  ? 438  TYR B CA    1 ? 
ATOM   7740  C  C     . TYR B 1 438 ? -41.787 6.892   -56.829  1    91.563  ? 438  TYR B C     1 ? 
ATOM   7741  O  O     . TYR B 1 438 ? -41.752 6.612   -58.027  1    101.465 ? 438  TYR B O     1 ? 
ATOM   7742  C  CB    . TYR B 1 438 ? -42.197 5.006   -55.112  1    78.374  ? 438  TYR B CB    1 ? 
ATOM   7743  C  CG    . TYR B 1 438 ? -41.619 3.751   -54.461  1    76.71   ? 438  TYR B CG    1 ? 
ATOM   7744  C  CD1   . TYR B 1 438 ? -40.725 2.927   -55.148  1    72.863  ? 438  TYR B CD1   1 ? 
ATOM   7745  C  CD2   . TYR B 1 438 ? -41.965 3.388   -53.159  1    71.146  ? 438  TYR B CD2   1 ? 
ATOM   7746  C  CE1   . TYR B 1 438 ? -40.197 1.788   -54.559  1    74.637  ? 438  TYR B CE1   1 ? 
ATOM   7747  C  CE2   . TYR B 1 438 ? -41.446 2.247   -52.564  1    74.782  ? 438  TYR B CE2   1 ? 
ATOM   7748  C  CZ    . TYR B 1 438 ? -40.56  1.441   -53.265  1    77.687  ? 438  TYR B CZ    1 ? 
ATOM   7749  O  OH    . TYR B 1 438 ? -40.039 0.305   -52.696  1    69.101  ? 438  TYR B OH    1 ? 
ATOM   7750  N  N     . MET B 1 439 ? -42.293 8.035   -56.344  1    99.709  ? 439  MET B N     1 ? 
ATOM   7751  C  CA    . MET B 1 439 ? -42.785 9.113   -57.191  1    96.628  ? 439  MET B CA    1 ? 
ATOM   7752  C  C     . MET B 1 439 ? -41.6   9.957   -57.671  1    96.867  ? 439  MET B C     1 ? 
ATOM   7753  O  O     . MET B 1 439 ? -41.412 11.087  -57.221  1    92.461  ? 439  MET B O     1 ? 
ATOM   7754  C  CB    . MET B 1 439 ? -43.843 9.951   -56.457  1    95.688  ? 439  MET B CB    1 ? 
ATOM   7755  C  CG    . MET B 1 439 ? -44.968 9.13    -55.82   1    110.661 ? 439  MET B CG    1 ? 
ATOM   7756  S  SD    . MET B 1 439 ? -46.328 9.971   -54.974  1    125.866 ? 439  MET B SD    1 ? 
ATOM   7757  C  CE    . MET B 1 439 ? -45.599 10.991  -53.683  1    113.483 ? 439  MET B CE    1 ? 
ATOM   7758  N  N     . THR B 1 440 ? -40.793 9.37    -58.571  1    100.103 ? 440  THR B N     1 ? 
ATOM   7759  C  CA    . THR B 1 440 ? -39.688 10.022  -59.262  1    99.09   ? 440  THR B CA    1 ? 
ATOM   7760  C  C     . THR B 1 440 ? -39.207 9.139   -60.404  1    105.137 ? 440  THR B C     1 ? 
ATOM   7761  O  O     . THR B 1 440 ? -39.167 7.898   -60.212  1    100.018 ? 440  THR B O     1 ? 
ATOM   7762  C  CB    . THR B 1 440 ? -38.562 10.395  -58.294  1    94.09   ? 440  THR B CB    1 ? 
ATOM   7763  O  OG1   . THR B 1 440 ? -38.911 11.708  -57.862  1    81.122  ? 440  THR B OG1   1 ? 
ATOM   7764  C  CG2   . THR B 1 440 ? -37.192 10.431  -58.952  1    88.056  ? 440  THR B CG2   1 ? 
ATOM   7765  N  N     . SER B 1 448 ? -49.688 4.283   -55.493  1    84.834  ? 448  SER B N     1 ? 
ATOM   7766  C  CA    . SER B 1 448 ? -50.491 3.036   -55.616  1    89.969  ? 448  SER B CA    1 ? 
ATOM   7767  C  C     . SER B 1 448 ? -49.833 1.905   -54.822  1    103.447 ? 448  SER B C     1 ? 
ATOM   7768  O  O     . SER B 1 448 ? -48.611 1.885   -54.655  1    100.433 ? 448  SER B O     1 ? 
ATOM   7769  C  CB    . SER B 1 448 ? -50.697 2.676   -57.074  1    82.822  ? 448  SER B CB    1 ? 
ATOM   7770  O  OG    . SER B 1 448 ? -51.446 1.479   -57.241  1    72.902  ? 448  SER B OG    1 ? 
ATOM   7771  N  N     . ASP B 1 449 ? -50.666 0.97    -54.337  1    108.808 ? 449  ASP B N     1 ? 
ATOM   7772  C  CA    . ASP B 1 449 ? -50.234 -0.123  -53.476  1    114.319 ? 449  ASP B CA    1 ? 
ATOM   7773  C  C     . ASP B 1 449 ? -49.749 -1.296  -54.327  1    107.95  ? 449  ASP B C     1 ? 
ATOM   7774  O  O     . ASP B 1 449 ? -48.772 -1.96   -53.982  1    104.463 ? 449  ASP B O     1 ? 
ATOM   7775  C  CB    . ASP B 1 449 ? -51.341 -0.556  -52.523  1    120.76  ? 449  ASP B CB    1 ? 
ATOM   7776  C  CG    . ASP B 1 449 ? -51.825 0.486   -51.522  1    119.971 ? 449  ASP B CG    1 ? 
ATOM   7777  O  OD1   . ASP B 1 449 ? -51.168 1.544   -51.404  1    116.247 ? 449  ASP B OD1   1 ? 
ATOM   7778  O  OD2   . ASP B 1 449 ? -52.866 0.239   -50.871  1    114.183 ? 449  ASP B OD2   1 ? 
ATOM   7779  N  N     . ASP B 1 450 ? -50.457 -1.539  -55.436  1    107.653 ? 450  ASP B N     1 ? 
ATOM   7780  C  CA    . ASP B 1 450 ? -50.17  -2.639  -56.343  1    104.895 ? 450  ASP B CA    1 ? 
ATOM   7781  C  C     . ASP B 1 450 ? -48.914 -2.346  -57.163  1    89.318  ? 450  ASP B C     1 ? 
ATOM   7782  O  O     . ASP B 1 450 ? -48.353 -3.251  -57.772  1    89.619  ? 450  ASP B O     1 ? 
ATOM   7783  C  CB    . ASP B 1 450 ? -51.39  -2.996  -57.181  1    113.022 ? 450  ASP B CB    1 ? 
ATOM   7784  C  CG    . ASP B 1 450 ? -52.366 -3.981  -56.549  1    110.775 ? 450  ASP B CG    1 ? 
ATOM   7785  O  OD1   . ASP B 1 450 ? -51.917 -4.821  -55.738  1    106.152 ? 450  ASP B OD1   1 ? 
ATOM   7786  O  OD2   . ASP B 1 450 ? -53.573 -3.884  -56.857  1    106.887 ? 450  ASP B OD2   1 ? 
ATOM   7787  N  N     . PHE B 1 451 ? -48.487 -1.079  -57.168  1    81.066  ? 451  PHE B N     1 ? 
ATOM   7788  C  CA    . PHE B 1 451 ? -47.231 -0.666  -57.768  1    85.823  ? 451  PHE B CA    1 ? 
ATOM   7789  C  C     . PHE B 1 451 ? -46.069 -1.264  -56.98   1    87.109  ? 451  PHE B C     1 ? 
ATOM   7790  O  O     . PHE B 1 451 ? -45.052 -1.638  -57.565  1    81.103  ? 451  PHE B O     1 ? 
ATOM   7791  C  CB    . PHE B 1 451 ? -47.106 0.86    -57.743  1    99.374  ? 451  PHE B CB    1 ? 
ATOM   7792  C  CG    . PHE B 1 451 ? -45.763 1.407   -58.219  1    116.046 ? 451  PHE B CG    1 ? 
ATOM   7793  C  CD1   . PHE B 1 451 ? -44.655 1.42    -57.371  1    117.485 ? 451  PHE B CD1   1 ? 
ATOM   7794  C  CD2   . PHE B 1 451 ? -45.616 1.925   -59.506  1    122.324 ? 451  PHE B CD2   1 ? 
ATOM   7795  C  CE1   . PHE B 1 451 ? -43.434 1.918   -57.806  1    122.979 ? 451  PHE B CE1   1 ? 
ATOM   7796  C  CE2   . PHE B 1 451 ? -44.394 2.43    -59.935  1    124.307 ? 451  PHE B CE2   1 ? 
ATOM   7797  C  CZ    . PHE B 1 451 ? -43.307 2.425   -59.084  1    126.089 ? 451  PHE B CZ    1 ? 
ATOM   7798  N  N     . LEU B 1 452 ? -46.222 -1.304  -55.651  1    89.301  ? 452  LEU B N     1 ? 
ATOM   7799  C  CA    . LEU B 1 452 ? -45.225 -1.872  -54.757  1    94.704  ? 452  LEU B CA    1 ? 
ATOM   7800  C  C     . LEU B 1 452 ? -45.021 -3.351  -55.076  1    84.095  ? 452  LEU B C     1 ? 
ATOM   7801  O  O     . LEU B 1 452 ? -43.904 -3.772  -55.369  1    85.504  ? 452  LEU B O     1 ? 
ATOM   7802  C  CB    . LEU B 1 452 ? -45.578 -1.649  -53.284  1    108.825 ? 452  LEU B CB    1 ? 
ATOM   7803  C  CG    . LEU B 1 452 ? -45.014 -0.384  -52.625  1    111.685 ? 452  LEU B CG    1 ? 
ATOM   7804  C  CD1   . LEU B 1 452 ? -45.653 0.894   -53.155  1    112.361 ? 452  LEU B CD1   1 ? 
ATOM   7805  C  CD2   . LEU B 1 452 ? -45.132 -0.464  -51.108  1    102.723 ? 452  LEU B CD2   1 ? 
ATOM   7806  N  N     . ALA B 1 453 ? -46.116 -4.119  -55.044  1    78.163  ? 453  ALA B N     1 ? 
ATOM   7807  C  CA    . ALA B 1 453 ? -46.064 -5.564  -55.202  1    67.782  ? 453  ALA B CA    1 ? 
ATOM   7808  C  C     . ALA B 1 453 ? -45.49  -5.944  -56.568  1    64.215  ? 453  ALA B C     1 ? 
ATOM   7809  O  O     . ALA B 1 453 ? -44.669 -6.854  -56.657  1    60.888  ? 453  ALA B O     1 ? 
ATOM   7810  C  CB    . ALA B 1 453 ? -47.438 -6.154  -54.971  1    65.346  ? 453  ALA B CB    1 ? 
ATOM   7811  N  N     . ASP B 1 454 ? -45.927 -5.243  -57.623  1    55.689  ? 454  ASP B N     1 ? 
ATOM   7812  C  CA    . ASP B 1 454 ? -45.465 -5.504  -58.976  1    59.397  ? 454  ASP B CA    1 ? 
ATOM   7813  C  C     . ASP B 1 454 ? -43.98  -5.175  -59.094  1    59.121  ? 454  ASP B C     1 ? 
ATOM   7814  O  O     . ASP B 1 454 ? -43.247 -5.892  -59.774  1    53.861  ? 454  ASP B O     1 ? 
ATOM   7815  C  CB    . ASP B 1 454 ? -46.298 -4.784  -60.027  1    61.623  ? 454  ASP B CB    1 ? 
ATOM   7816  C  CG    . ASP B 1 454 ? -47.782 -5.138  -60.043  1    75.818  ? 454  ASP B CG    1 ? 
ATOM   7817  O  OD1   . ASP B 1 454 ? -48.142 -6.199  -59.458  1    64.074  ? 454  ASP B OD1   1 ? 
ATOM   7818  O  OD2   . ASP B 1 454 ? -48.574 -4.328  -60.606  1    71.371  ? 454  ASP B OD2   1 ? 
ATOM   7819  N  N     . GLN B 1 455 ? -43.551 -4.082  -58.443  1    61.622  ? 455  GLN B N     1 ? 
ATOM   7820  C  CA    . GLN B 1 455 ? -42.16  -3.669  -58.552  1    63.29   ? 455  GLN B CA    1 ? 
ATOM   7821  C  C     . GLN B 1 455 ? -41.306 -4.686  -57.801  1    59.674  ? 455  GLN B C     1 ? 
ATOM   7822  O  O     . GLN B 1 455 ? -40.267 -5.101  -58.312  1    57.966  ? 455  GLN B O     1 ? 
ATOM   7823  C  CB    . GLN B 1 455 ? -41.775 -2.227  -58.198  1    59.184  ? 455  GLN B CB    1 ? 
ATOM   7824  C  CG    . GLN B 1 455 ? -40.395 -1.846  -58.739  1    53.799  ? 455  GLN B CG    1 ? 
ATOM   7825  C  CD    . GLN B 1 455 ? -39.847 -0.527  -58.235  1    58.243  ? 455  GLN B CD    1 ? 
ATOM   7826  O  OE1   . GLN B 1 455 ? -40.485 0.169   -57.44   1    56.403  ? 455  GLN B OE1   1 ? 
ATOM   7827  N  NE2   . GLN B 1 455 ? -38.651 -0.17   -58.696  1    53.61   ? 455  GLN B NE2   1 ? 
ATOM   7828  N  N     . ALA B 1 456 ? -41.777 -5.064  -56.607  1    50.458  ? 456  ALA B N     1 ? 
ATOM   7829  C  CA    . ALA B 1 456 ? -41.207 -6.14   -55.811  1    46.826  ? 456  ALA B CA    1 ? 
ATOM   7830  C  C     . ALA B 1 456 ? -41.06  -7.411  -56.648  1    46.772  ? 456  ALA B C     1 ? 
ATOM   7831  O  O     . ALA B 1 456 ? -39.977 -7.975  -56.704  1    52.789  ? 456  ALA B O     1 ? 
ATOM   7832  C  CB    . ALA B 1 456 ? -42.062 -6.389  -54.584  1    45.298  ? 456  ALA B CB    1 ? 
ATOM   7833  N  N     . ALA B 1 457 ? -42.145 -7.84   -57.309  1    43.182  ? 457  ALA B N     1 ? 
ATOM   7834  C  CA    . ALA B 1 457 ? -42.175 -9.083  -58.067  1    41.875  ? 457  ALA B CA    1 ? 
ATOM   7835  C  C     . ALA B 1 457 ? -41.174 -9.058  -59.222  1    42.759  ? 457  ALA B C     1 ? 
ATOM   7836  O  O     . ALA B 1 457 ? -40.452 -10.034 -59.434  1    43.537  ? 457  ALA B O     1 ? 
ATOM   7837  C  CB    . ALA B 1 457 ? -43.583 -9.358  -58.553  1    44.275  ? 457  ALA B CB    1 ? 
ATOM   7838  N  N     . CYS B 1 458 ? -41.128 -7.928  -59.943  1    40.513  ? 458  CYS B N     1 ? 
ATOM   7839  C  CA    . CYS B 1 458 ? -40.232 -7.734  -61.07   1    41.366  ? 458  CYS B CA    1 ? 
ATOM   7840  C  C     . CYS B 1 458 ? -38.778 -7.796  -60.618  1    38.429  ? 458  CYS B C     1 ? 
ATOM   7841  O  O     . CYS B 1 458 ? -37.914 -8.258  -61.354  1    39.995  ? 458  CYS B O     1 ? 
ATOM   7842  C  CB    . CYS B 1 458 ? -40.475 -6.391  -61.749  1    49.409  ? 458  CYS B CB    1 ? 
ATOM   7843  S  SG    . CYS B 1 458 ? -42.023 -6.371  -62.69   1    62.505  ? 458  CYS B SG    1 ? 
ATOM   7844  N  N     . TYR B 1 459 ? -38.529 -7.299  -59.411  1    38.442  ? 459  TYR B N     1 ? 
ATOM   7845  C  CA    . TYR B 1 459 ? -37.188 -7.28   -58.859  1    43.484  ? 459  TYR B CA    1 ? 
ATOM   7846  C  C     . TYR B 1 459 ? -36.722 -8.709  -58.59   1    38.472  ? 459  TYR B C     1 ? 
ATOM   7847  O  O     . TYR B 1 459 ? -35.613 -9.085  -58.954  1    38.621  ? 459  TYR B O     1 ? 
ATOM   7848  C  CB    . TYR B 1 459 ? -37.115 -6.334  -57.654  1    42.847  ? 459  TYR B CB    1 ? 
ATOM   7849  C  CG    . TYR B 1 459 ? -35.668 -6.092  -57.255  1    43.718  ? 459  TYR B CG    1 ? 
ATOM   7850  C  CD1   . TYR B 1 459 ? -34.819 -5.35   -58.069  1    48.154  ? 459  TYR B CD1   1 ? 
ATOM   7851  C  CD2   . TYR B 1 459 ? -35.14  -6.645  -56.098  1    44.726  ? 459  TYR B CD2   1 ? 
ATOM   7852  C  CE1   . TYR B 1 459 ? -33.486 -5.149  -57.74   1    51.922  ? 459  TYR B CE1   1 ? 
ATOM   7853  C  CE2   . TYR B 1 459 ? -33.81  -6.446  -55.756  1    52.247  ? 459  TYR B CE2   1 ? 
ATOM   7854  C  CZ    . TYR B 1 459 ? -32.98  -5.7    -56.575  1    49.53   ? 459  TYR B CZ    1 ? 
ATOM   7855  O  OH    . TYR B 1 459 ? -31.668 -5.502  -56.242  1    54.148  ? 459  TYR B OH    1 ? 
ATOM   7856  N  N     . VAL B 1 460 ? -37.592 -9.518  -57.99   1    38.679  ? 460  VAL B N     1 ? 
ATOM   7857  C  CA    . VAL B 1 460 ? -37.262 -10.913 -57.74   1    42.332  ? 460  VAL B CA    1 ? 
ATOM   7858  C  C     . VAL B 1 460 ? -37.009 -11.638 -59.065  1    41.807  ? 460  VAL B C     1 ? 
ATOM   7859  O  O     . VAL B 1 460 ? -36.044 -12.408 -59.194  1    36.89   ? 460  VAL B O     1 ? 
ATOM   7860  C  CB    . VAL B 1 460 ? -38.369 -11.597 -56.913  1    42.146  ? 460  VAL B CB    1 ? 
ATOM   7861  C  CG1   . VAL B 1 460 ? -37.985 -13.016 -56.498  1    38.853  ? 460  VAL B CG1   1 ? 
ATOM   7862  C  CG2   . VAL B 1 460 ? -38.692 -10.758 -55.684  1    54.06   ? 460  VAL B CG2   1 ? 
ATOM   7863  N  N     . GLN B 1 461 ? -37.888 -11.372 -60.045  1    38.208  ? 461  GLN B N     1 ? 
ATOM   7864  C  CA    . GLN B 1 461 ? -37.757 -11.934 -61.376  1    38.975  ? 461  GLN B CA    1 ? 
ATOM   7865  C  C     . GLN B 1 461 ? -36.406 -11.537 -61.949  1    35.578  ? 461  GLN B C     1 ? 
ATOM   7866  O  O     . GLN B 1 461 ? -35.731 -12.362 -62.554  1    35.159  ? 461  GLN B O     1 ? 
ATOM   7867  C  CB    . GLN B 1 461 ? -38.812 -11.382 -62.335  1    45.22   ? 461  GLN B CB    1 ? 
ATOM   7868  C  CG    . GLN B 1 461 ? -40.236 -11.794 -61.982  1    60.165  ? 461  GLN B CG    1 ? 
ATOM   7869  C  CD    . GLN B 1 461 ? -41.301 -11.144 -62.845  1    73.226  ? 461  GLN B CD    1 ? 
ATOM   7870  O  OE1   . GLN B 1 461 ? -41.016 -10.523 -63.882  1    69.078  ? 461  GLN B OE1   1 ? 
ATOM   7871  N  NE2   . GLN B 1 461 ? -42.547 -11.296 -62.412  1    62.305  ? 461  GLN B NE2   1 ? 
ATOM   7872  N  N     . ALA B 1 462 ? -36.038 -10.266 -61.752  1    34.715  ? 462  ALA B N     1 ? 
ATOM   7873  C  CA    . ALA B 1 462 ? -34.758 -9.775  -62.24   1    37.525  ? 462  ALA B CA    1 ? 
ATOM   7874  C  C     . ALA B 1 462 ? -33.612 -10.579 -61.638  1    37.959  ? 462  ALA B C     1 ? 
ATOM   7875  O  O     . ALA B 1 462 ? -32.644 -10.879 -62.333  1    34.937  ? 462  ALA B O     1 ? 
ATOM   7876  C  CB    . ALA B 1 462 ? -34.604 -8.297  -61.935  1    34.76   ? 462  ALA B CB    1 ? 
ATOM   7877  N  N     . ILE B 1 463 ? -33.703 -10.872 -60.329  1    36.165  ? 463  ILE B N     1 ? 
ATOM   7878  C  CA    . ILE B 1 463 ? -32.618 -11.606 -59.698  1    37.542  ? 463  ILE B CA    1 ? 
ATOM   7879  C  C     . ILE B 1 463 ? -32.534 -12.982 -60.332  1    31.407  ? 463  ILE B C     1 ? 
ATOM   7880  O  O     . ILE B 1 463 ? -31.444 -13.427 -60.667  1    35.096  ? 463  ILE B O     1 ? 
ATOM   7881  C  CB    . ILE B 1 463 ? -32.79  -11.716 -58.169  1    43.498  ? 463  ILE B CB    1 ? 
ATOM   7882  C  CG1   . ILE B 1 463 ? -33.016 -10.347 -57.536  1    40.572  ? 463  ILE B CG1   1 ? 
ATOM   7883  C  CG2   . ILE B 1 463 ? -31.581 -12.429 -57.552  1    38.019  ? 463  ILE B CG2   1 ? 
ATOM   7884  C  CD1   . ILE B 1 463 ? -31.777 -9.476  -57.538  1    49.913  ? 463  ILE B CD1   1 ? 
ATOM   7885  N  N     . GLN B 1 464 ? -33.692 -13.642 -60.485  1    32.704  ? 464  GLN B N     1 ? 
ATOM   7886  C  CA    . GLN B 1 464 ? -33.696 -14.971 -61.083  1    34.345  ? 464  GLN B CA    1 ? 
ATOM   7887  C  C     . GLN B 1 464 ? -33.14  -14.887 -62.506  1    37.819  ? 464  GLN B C     1 ? 
ATOM   7888  O  O     . GLN B 1 464 ? -32.379 -15.768 -62.912  1    34.392  ? 464  GLN B O     1 ? 
ATOM   7889  C  CB    . GLN B 1 464 ? -35.043 -15.707 -61.03   1    36.552  ? 464  GLN B CB    1 ? 
ATOM   7890  C  CG    . GLN B 1 464 ? -35.006 -17.155 -61.529  1    35.157  ? 464  GLN B CG    1 ? 
ATOM   7891  C  CD    . GLN B 1 464 ? -34.045 -18.056 -60.758  1    39.79   ? 464  GLN B CD    1 ? 
ATOM   7892  O  OE1   . GLN B 1 464 ? -34.347 -18.622 -59.697  1    37.064  ? 464  GLN B OE1   1 ? 
ATOM   7893  N  NE2   . GLN B 1 464 ? -32.838 -18.171 -61.275  1    33.894  ? 464  GLN B NE2   1 ? 
ATOM   7894  N  N     . TRP B 1 465 ? -33.481 -13.801 -63.238  1    35.511  ? 465  TRP B N     1 ? 
ATOM   7895  C  CA    . TRP B 1 465 ? -33.027 -13.687 -64.625  1    34.275  ? 465  TRP B CA    1 ? 
ATOM   7896  C  C     . TRP B 1 465 ? -31.507 -13.669 -64.671  1    30.772  ? 465  TRP B C     1 ? 
ATOM   7897  O  O     . TRP B 1 465 ? -30.914 -14.438 -65.421  1    34.847  ? 465  TRP B O     1 ? 
ATOM   7898  C  CB    . TRP B 1 465 ? -33.649 -12.498 -65.373  1    33.092  ? 465  TRP B CB    1 ? 
ATOM   7899  C  CG    . TRP B 1 465 ? -33.305 -12.447 -66.846  1    29.569  ? 465  TRP B CG    1 ? 
ATOM   7900  C  CD1   . TRP B 1 465 ? -34.083 -12.858 -67.889  1    30.191  ? 465  TRP B CD1   1 ? 
ATOM   7901  C  CD2   . TRP B 1 465 ? -32.088 -11.934 -67.428  1    30.859  ? 465  TRP B CD2   1 ? 
ATOM   7902  N  NE1   . TRP B 1 465 ? -33.432 -12.647 -69.081  1    34.34   ? 465  TRP B NE1   1 ? 
ATOM   7903  C  CE2   . TRP B 1 465 ? -32.205 -12.089 -68.828  1    33.346  ? 465  TRP B CE2   1 ? 
ATOM   7904  C  CE3   . TRP B 1 465 ? -30.923 -11.35  -66.902  1    31.765  ? 465  TRP B CE3   1 ? 
ATOM   7905  C  CZ2   . TRP B 1 465 ? -31.199 -11.686 -69.702  1    32.61   ? 465  TRP B CZ2   1 ? 
ATOM   7906  C  CZ3   . TRP B 1 465 ? -29.932 -10.949 -67.767  1    33.866  ? 465  TRP B CZ3   1 ? 
ATOM   7907  C  CH2   . TRP B 1 465 ? -30.069 -11.126 -69.154  1    34.541  ? 465  TRP B CH2   1 ? 
ATOM   7908  N  N     . ILE B 1 466 ? -30.901 -12.853 -63.802  1    31.931  ? 466  ILE B N     1 ? 
ATOM   7909  C  CA    A ILE B 1 466 ? -29.458 -12.681 -63.701  0.5  33.678  ? 466  ILE B CA    1 ? 
ATOM   7910  C  CA    B ILE B 1 466 ? -29.454 -12.705 -63.779  0.5  31.818  ? 466  ILE B CA    1 ? 
ATOM   7911  C  C     . ILE B 1 466 ? -28.797 -14.001 -63.296  1    32.219  ? 466  ILE B C     1 ? 
ATOM   7912  O  O     . ILE B 1 466 ? -27.748 -14.382 -63.821  1    32.364  ? 466  ILE B O     1 ? 
ATOM   7913  C  CB    A ILE B 1 466 ? -29.148 -11.548 -62.699  0.5  37.715  ? 466  ILE B CB    1 ? 
ATOM   7914  C  CB    B ILE B 1 466 ? -29.003 -11.438 -63.012  0.5  33.124  ? 466  ILE B CB    1 ? 
ATOM   7915  C  CG1   A ILE B 1 466 ? -29.796 -10.236 -63.119  0.5  36.67   ? 466  ILE B CG1   1 ? 
ATOM   7916  C  CG1   B ILE B 1 466 ? -27.509 -11.144 -63.213  0.5  33.88   ? 466  ILE B CG1   1 ? 
ATOM   7917  C  CG2   A ILE B 1 466 ? -27.644 -11.38  -62.485  0.5  38.18   ? 466  ILE B CG2   1 ? 
ATOM   7918  C  CG2   B ILE B 1 466 ? -29.368 -11.489 -61.523  0.5  27.68   ? 466  ILE B CG2   1 ? 
ATOM   7919  C  CD1   A ILE B 1 466 ? -29.751 -9.137  -62.066  0.5  38.611  ? 466  ILE B CD1   1 ? 
ATOM   7920  C  CD1   B ILE B 1 466 ? -27.153 -10.453 -64.518  0.5  39.749  ? 466  ILE B CD1   1 ? 
ATOM   7921  N  N     . LEU B 1 467 ? -29.4   -14.696 -62.316  1    35.662  ? 467  LEU B N     1 ? 
ATOM   7922  C  CA    . LEU B 1 467 ? -28.843 -15.975 -61.871  1    35.759  ? 467  LEU B CA    1 ? 
ATOM   7923  C  C     . LEU B 1 467 ? -28.804 -16.964 -63.031  1    34.343  ? 467  LEU B C     1 ? 
ATOM   7924  O  O     . LEU B 1 467 ? -27.784 -17.619 -63.241  1    33.966  ? 467  LEU B O     1 ? 
ATOM   7925  C  CB    . LEU B 1 467 ? -29.569 -16.564 -60.658  1    35.165  ? 467  LEU B CB    1 ? 
ATOM   7926  C  CG    . LEU B 1 467 ? -29.295 -15.837 -59.333  1    34.908  ? 467  LEU B CG    1 ? 
ATOM   7927  C  CD1   . LEU B 1 467 ? -30.241 -16.226 -58.242  1    32.847  ? 467  LEU B CD1   1 ? 
ATOM   7928  C  CD2   . LEU B 1 467 ? -27.872 -16.044 -58.88   1    37.34   ? 467  LEU B CD2   1 ? 
ATOM   7929  N  N     . HIS B 1 468 ? -29.947 -17.124 -63.721  1    33.462  ? 468  HIS B N     1 ? 
ATOM   7930  C  CA    . HIS B 1 468 ? -30.003 -17.91  -64.956  1    36.878  ? 468  HIS B CA    1 ? 
ATOM   7931  C  C     . HIS B 1 468 ? -28.895 -17.507 -65.931  1    33.076  ? 468  HIS B C     1 ? 
ATOM   7932  O  O     . HIS B 1 468 ? -28.175 -18.369 -66.45   1    33.324  ? 468  HIS B O     1 ? 
ATOM   7933  C  CB    . HIS B 1 468 ? -31.375 -17.781 -65.634  1    32.541  ? 468  HIS B CB    1 ? 
ATOM   7934  C  CG    . HIS B 1 468 ? -32.445 -18.657 -65.032  1    36.866  ? 468  HIS B CG    1 ? 
ATOM   7935  N  ND1   . HIS B 1 468 ? -32.181 -19.919 -64.543  1    38.696  ? 468  HIS B ND1   1 ? 
ATOM   7936  C  CD2   . HIS B 1 468 ? -33.763 -18.47  -64.848  1    34.462  ? 468  HIS B CD2   1 ? 
ATOM   7937  C  CE1   . HIS B 1 468 ? -33.317 -20.455 -64.085  1    43.371  ? 468  HIS B CE1   1 ? 
ATOM   7938  N  NE2   . HIS B 1 468 ? -34.281 -19.588 -64.245  1    36.797  ? 468  HIS B NE2   1 ? 
ATOM   7939  N  N     . TYR B 1 469 ? -28.748 -16.191 -66.178  1    34.13   ? 469  TYR B N     1 ? 
ATOM   7940  C  CA    . TYR B 1 469 ? -27.79  -15.708 -67.17   1    34.962  ? 469  TYR B CA    1 ? 
ATOM   7941  C  C     . TYR B 1 469 ? -26.394 -16.266 -66.874  1    36.022  ? 469  TYR B C     1 ? 
ATOM   7942  O  O     . TYR B 1 469 ? -25.642 -16.648 -67.784  1    38.421  ? 469  TYR B O     1 ? 
ATOM   7943  C  CB    . TYR B 1 469 ? -27.822 -14.174 -67.182  1    38.705  ? 469  TYR B CB    1 ? 
ATOM   7944  C  CG    . TYR B 1 469 ? -26.992 -13.421 -68.227  1    43.65   ? 469  TYR B CG    1 ? 
ATOM   7945  C  CD1   . TYR B 1 469 ? -27.46  -13.235 -69.526  1    48.506  ? 469  TYR B CD1   1 ? 
ATOM   7946  C  CD2   . TYR B 1 469 ? -25.758 -12.858 -67.914  1    43.782  ? 469  TYR B CD2   1 ? 
ATOM   7947  C  CE1   . TYR B 1 469 ? -26.738 -12.517 -70.471  1    45.441  ? 469  TYR B CE1   1 ? 
ATOM   7948  C  CE2   . TYR B 1 469 ? -25.017 -12.148 -68.848  1    45.162  ? 469  TYR B CE2   1 ? 
ATOM   7949  C  CZ    . TYR B 1 469 ? -25.519 -11.964 -70.13   1    44.77   ? 469  TYR B CZ    1 ? 
ATOM   7950  O  OH    . TYR B 1 469 ? -24.817 -11.255 -71.073  1    45.812  ? 469  TYR B OH    1 ? 
ATOM   7951  N  N     . TYR B 1 470 ? -26.033 -16.263 -65.582  1    35.68   ? 470  TYR B N     1 ? 
ATOM   7952  C  CA    . TYR B 1 470 ? -24.693 -16.628 -65.147  1    35.207  ? 470  TYR B CA    1 ? 
ATOM   7953  C  C     . TYR B 1 470 ? -24.481 -18.149 -65.144  1    36.277  ? 470  TYR B C     1 ? 
ATOM   7954  O  O     . TYR B 1 470 ? -23.422 -18.624 -65.541  1    38.49   ? 470  TYR B O     1 ? 
ATOM   7955  C  CB    . TYR B 1 470 ? -24.332 -15.96  -63.811  1    34.342  ? 470  TYR B CB    1 ? 
ATOM   7956  C  CG    . TYR B 1 470 ? -23.74  -14.573 -63.999  1    36.248  ? 470  TYR B CG    1 ? 
ATOM   7957  C  CD1   . TYR B 1 470 ? -24.561 -13.467 -64.167  1    37.61   ? 470  TYR B CD1   1 ? 
ATOM   7958  C  CD2   . TYR B 1 470 ? -22.364 -14.377 -64.052  1    40.746  ? 470  TYR B CD2   1 ? 
ATOM   7959  C  CE1   . TYR B 1 470 ? -24.04  -12.196 -64.353  1    39.521  ? 470  TYR B CE1   1 ? 
ATOM   7960  C  CE2   . TYR B 1 470 ? -21.828 -13.111 -64.235  1    41.246  ? 470  TYR B CE2   1 ? 
ATOM   7961  C  CZ    . TYR B 1 470 ? -22.67  -12.023 -64.393  1    41.763  ? 470  TYR B CZ    1 ? 
ATOM   7962  O  OH    . TYR B 1 470 ? -22.165 -10.767 -64.587  1    46.899  ? 470  TYR B OH    1 ? 
ATOM   7963  N  N     . TYR B 1 471 ? -25.475 -18.913 -64.696  1    33.015  ? 471  TYR B N     1 ? 
ATOM   7964  C  CA    . TYR B 1 471 ? -25.247 -20.324 -64.404  1    37.713  ? 471  TYR B CA    1 ? 
ATOM   7965  C  C     . TYR B 1 471 ? -25.731 -21.2   -65.564  1    41.011  ? 471  TYR B C     1 ? 
ATOM   7966  O  O     . TYR B 1 471 ? -25.189 -22.275 -65.822  1    39.902  ? 471  TYR B O     1 ? 
ATOM   7967  C  CB    . TYR B 1 471 ? -26.041 -20.616 -63.124  1    33.87   ? 471  TYR B CB    1 ? 
ATOM   7968  C  CG    . TYR B 1 471 ? -25.376 -20.143 -61.84   1    40.553  ? 471  TYR B CG    1 ? 
ATOM   7969  C  CD1   . TYR B 1 471 ? -25.527 -18.831 -61.41   1    34.346  ? 471  TYR B CD1   1 ? 
ATOM   7970  C  CD2   . TYR B 1 471 ? -24.604 -21.005 -61.054  1    39.388  ? 471  TYR B CD2   1 ? 
ATOM   7971  C  CE1   . TYR B 1 471 ? -24.951 -18.384 -60.238  1    38.082  ? 471  TYR B CE1   1 ? 
ATOM   7972  C  CE2   . TYR B 1 471 ? -24.008 -20.56  -59.879  1    38.171  ? 471  TYR B CE2   1 ? 
ATOM   7973  C  CZ    . TYR B 1 471 ? -24.17  -19.241 -59.478  1    39.284  ? 471  TYR B CZ    1 ? 
ATOM   7974  O  OH    . TYR B 1 471 ? -23.614 -18.737 -58.323  1    40.25   ? 471  TYR B OH    1 ? 
ATOM   7975  N  N     . HIS B 1 472 ? -26.797 -20.756 -66.241  1    42.522  ? 472  HIS B N     1 ? 
ATOM   7976  C  CA    . HIS B 1 472 ? -27.471 -21.597 -67.219  1    40.569  ? 472  HIS B CA    1 ? 
ATOM   7977  C  C     . HIS B 1 472 ? -27.462 -20.984 -68.618  1    43.626  ? 472  HIS B C     1 ? 
ATOM   7978  O  O     . HIS B 1 472 ? -27.73  -21.702 -69.577  1    42.212  ? 472  HIS B O     1 ? 
ATOM   7979  C  CB    . HIS B 1 472 ? -28.937 -21.794 -66.831  1    36.408  ? 472  HIS B CB    1 ? 
ATOM   7980  C  CG    . HIS B 1 472 ? -29.095 -22.229 -65.422  1    40.693  ? 472  HIS B CG    1 ? 
ATOM   7981  N  ND1   . HIS B 1 472 ? -29.943 -21.602 -64.537  1    39.238  ? 472  HIS B ND1   1 ? 
ATOM   7982  C  CD2   . HIS B 1 472 ? -28.492 -23.225 -64.739  1    42.363  ? 472  HIS B CD2   1 ? 
ATOM   7983  C  CE1   . HIS B 1 472 ? -29.87  -22.227 -63.365  1    48.03   ? 472  HIS B CE1   1 ? 
ATOM   7984  N  NE2   . HIS B 1 472 ? -29     -23.217 -63.468  1    39.326  ? 472  HIS B NE2   1 ? 
ATOM   7985  N  N     . GLY B 1 473 ? -27.179 -19.68  -68.739  1    38.941  ? 473  GLY B N     1 ? 
ATOM   7986  C  CA    . GLY B 1 473 ? -27.332 -19.021 -70.028  1    38.153  ? 473  GLY B CA    1 ? 
ATOM   7987  C  C     . GLY B 1 473 ? -28.691 -18.328 -70.082  1    38.816  ? 473  GLY B C     1 ? 
ATOM   7988  O  O     . GLY B 1 473 ? -29.499 -18.471 -69.165  1    44.82   ? 473  GLY B O     1 ? 
ATOM   7989  N  N     . VAL B 1 474 ? -28.915 -17.547 -71.143  1    37.333  ? 474  VAL B N     1 ? 
ATOM   7990  C  CA    . VAL B 1 474 ? -30.04  -16.632 -71.212  1    39.957  ? 474  VAL B CA    1 ? 
ATOM   7991  C  C     . VAL B 1 474 ? -31.317 -17.46  -71.207  1    34.731  ? 474  VAL B C     1 ? 
ATOM   7992  O  O     . VAL B 1 474 ? -31.401 -18.433 -71.935  1    36.806  ? 474  VAL B O     1 ? 
ATOM   7993  C  CB    . VAL B 1 474 ? -30.012 -15.716 -72.453  1    45.579  ? 474  VAL B CB    1 ? 
ATOM   7994  C  CG1   . VAL B 1 474 ? -31.083 -14.644 -72.318  1    50.385  ? 474  VAL B CG1   1 ? 
ATOM   7995  C  CG2   . VAL B 1 474 ? -28.657 -15.054 -72.656  1    51.6    ? 474  VAL B CG2   1 ? 
ATOM   7996  N  N     . GLN B 1 475 ? -32.27  -17.09  -70.355  1    34.825  ? 475  GLN B N     1 ? 
ATOM   7997  C  CA    . GLN B 1 475 ? -33.506 -17.841 -70.248  1    34.211  ? 475  GLN B CA    1 ? 
ATOM   7998  C  C     . GLN B 1 475 ? -34.659 -17.027 -70.822  1    37.859  ? 475  GLN B C     1 ? 
ATOM   7999  O  O     . GLN B 1 475 ? -35.776 -17.539 -70.908  1    37.646  ? 475  GLN B O     1 ? 
ATOM   8000  C  CB    . GLN B 1 475 ? -33.801 -18.3   -68.818  1    36.68   ? 475  GLN B CB    1 ? 
ATOM   8001  C  CG    . GLN B 1 475 ? -32.917 -19.449 -68.336  1    39.288  ? 475  GLN B CG    1 ? 
ATOM   8002  C  CD    . GLN B 1 475 ? -32.888 -20.646 -69.271  1    44.891  ? 475  GLN B CD    1 ? 
ATOM   8003  O  OE1   . GLN B 1 475 ? -33.921 -21.28  -69.553  1    42.07   ? 475  GLN B OE1   1 ? 
ATOM   8004  N  NE2   . GLN B 1 475 ? -31.687 -20.976 -69.743  1    34.336  ? 475  GLN B NE2   1 ? 
ATOM   8005  N  N     . SER B 1 476 ? -34.395 -15.751 -71.149  1    34.826  ? 476  SER B N     1 ? 
ATOM   8006  C  CA    . SER B 1 476 ? -35.343 -14.922 -71.871  1    34.786  ? 476  SER B CA    1 ? 
ATOM   8007  C  C     . SER B 1 476 ? -34.595 -13.791 -72.56   1    38.953  ? 476  SER B C     1 ? 
ATOM   8008  O  O     . SER B 1 476 ? -33.899 -13.005 -71.903  1    37.357  ? 476  SER B O     1 ? 
ATOM   8009  C  CB    . SER B 1 476 ? -36.436 -14.349 -71.004  1    39.345  ? 476  SER B CB    1 ? 
ATOM   8010  O  OG    . SER B 1 476 ? -37.18  -13.395 -71.777  1    36.405  ? 476  SER B OG    1 ? 
ATOM   8011  N  N     . TRP B 1 477 ? -34.789 -13.713 -73.883  1    32.9    ? 477  TRP B N     1 ? 
ATOM   8012  C  CA    . TRP B 1 477 ? -34.169 -12.682 -74.701  1    31.348  ? 477  TRP B CA    1 ? 
ATOM   8013  C  C     . TRP B 1 477 ? -34.999 -11.4   -74.667  1    30.052  ? 477  TRP B C     1 ? 
ATOM   8014  O  O     . TRP B 1 477 ? -34.489 -10.338 -75.015  1    34.197  ? 477  TRP B O     1 ? 
ATOM   8015  C  CB    . TRP B 1 477 ? -34.04  -13.199 -76.14   1    35.188  ? 477  TRP B CB    1 ? 
ATOM   8016  C  CG    . TRP B 1 477 ? -32.875 -14.134 -76.301  1    33.66   ? 477  TRP B CG    1 ? 
ATOM   8017  C  CD1   . TRP B 1 477 ? -32.878 -15.489 -76.159  1    31.503  ? 477  TRP B CD1   1 ? 
ATOM   8018  C  CD2   . TRP B 1 477 ? -31.513 -13.744 -76.586  1    27.89   ? 477  TRP B CD2   1 ? 
ATOM   8019  N  NE1   . TRP B 1 477 ? -31.606 -15.969 -76.365  1    32.605  ? 477  TRP B NE1   1 ? 
ATOM   8020  C  CE2   . TRP B 1 477 ? -30.752 -14.926 -76.63   1    28.432  ? 477  TRP B CE2   1 ? 
ATOM   8021  C  CE3   . TRP B 1 477 ? -30.876 -12.512 -76.818  1    31.301  ? 477  TRP B CE3   1 ? 
ATOM   8022  C  CZ2   . TRP B 1 477 ? -29.377 -14.916 -76.874  1    28.612  ? 477  TRP B CZ2   1 ? 
ATOM   8023  C  CZ3   . TRP B 1 477 ? -29.521 -12.503 -77.063  1    29.848  ? 477  TRP B CZ3   1 ? 
ATOM   8024  C  CH2   . TRP B 1 477 ? -28.787 -13.689 -77.093  1    29.296  ? 477  TRP B CH2   1 ? 
ATOM   8025  N  N     . SER B 1 478 ? -36.269 -11.505 -74.255  1    28.658  ? 478  SER B N     1 ? 
ATOM   8026  C  CA    . SER B 1 478 ? -37.194 -10.39  -74.335  1    34.144  ? 478  SER B CA    1 ? 
ATOM   8027  C  C     . SER B 1 478 ? -37.433 -9.739  -72.972  1    40.491  ? 478  SER B C     1 ? 
ATOM   8028  O  O     . SER B 1 478 ? -37.759 -8.554  -72.916  1    40.083  ? 478  SER B O     1 ? 
ATOM   8029  C  CB    . SER B 1 478 ? -38.497 -10.829 -74.915  1    37.175  ? 478  SER B CB    1 ? 
ATOM   8030  O  OG    . SER B 1 478 ? -39.042 -11.82  -74.061  1    46.153  ? 478  SER B OG    1 ? 
ATOM   8031  N  N     . TRP B 1 479 ? -37.285 -10.493 -71.873  1    39.965  ? 479  TRP B N     1 ? 
ATOM   8032  C  CA    . TRP B 1 479 ? -37.568 -9.944  -70.546  1    34.76   ? 479  TRP B CA    1 ? 
ATOM   8033  C  C     . TRP B 1 479 ? -36.687 -8.727  -70.244  1    33.11   ? 479  TRP B C     1 ? 
ATOM   8034  O  O     . TRP B 1 479 ? -35.511 -8.689  -70.606  1    35.96   ? 479  TRP B O     1 ? 
ATOM   8035  C  CB    . TRP B 1 479 ? -37.434 -11.013 -69.451  1    37.724  ? 479  TRP B CB    1 ? 
ATOM   8036  C  CG    . TRP B 1 479 ? -37.764 -10.474 -68.083  1    36.183  ? 479  TRP B CG    1 ? 
ATOM   8037  C  CD1   . TRP B 1 479 ? -38.989 -10.421 -67.476  1    38.075  ? 479  TRP B CD1   1 ? 
ATOM   8038  C  CD2   . TRP B 1 479 ? -36.839 -9.829  -67.184  1    33.951  ? 479  TRP B CD2   1 ? 
ATOM   8039  N  NE1   . TRP B 1 479 ? -38.884 -9.841  -66.24   1    38.492  ? 479  TRP B NE1   1 ? 
ATOM   8040  C  CE2   . TRP B 1 479 ? -37.579 -9.451  -66.041  1    37.167  ? 479  TRP B CE2   1 ? 
ATOM   8041  C  CE3   . TRP B 1 479 ? -35.47  -9.549  -67.232  1    37.97   ? 479  TRP B CE3   1 ? 
ATOM   8042  C  CZ2   . TRP B 1 479 ? -36.986 -8.798  -64.965  1    36.96   ? 479  TRP B CZ2   1 ? 
ATOM   8043  C  CZ3   . TRP B 1 479 ? -34.886 -8.897  -66.164  1    44.102  ? 479  TRP B CZ3   1 ? 
ATOM   8044  C  CH2   . TRP B 1 479 ? -35.642 -8.508  -65.057  1    39.715  ? 479  TRP B CH2   1 ? 
ATOM   8045  N  N     . TYR B 1 480 ? -37.259 -7.732  -69.561  1    34.48   ? 480  TYR B N     1 ? 
ATOM   8046  C  CA    . TYR B 1 480 ? -36.442 -6.653  -69.023  1    39.046  ? 480  TYR B CA    1 ? 
ATOM   8047  C  C     . TYR B 1 480 ? -37.084 -6.122  -67.738  1    41.737  ? 480  TYR B C     1 ? 
ATOM   8048  O  O     . TYR B 1 480 ? -38.275 -6.36   -67.467  1    36.101  ? 480  TYR B O     1 ? 
ATOM   8049  C  CB    . TYR B 1 480 ? -36.179 -5.572  -70.085  1    36.567  ? 480  TYR B CB    1 ? 
ATOM   8050  C  CG    . TYR B 1 480 ? -37.434 -4.764  -70.366  1    40.542  ? 480  TYR B CG    1 ? 
ATOM   8051  C  CD1   . TYR B 1 480 ? -38.431 -5.246  -71.213  1    48.649  ? 480  TYR B CD1   1 ? 
ATOM   8052  C  CD2   . TYR B 1 480 ? -37.635 -3.536  -69.752  1    43.423  ? 480  TYR B CD2   1 ? 
ATOM   8053  C  CE1   . TYR B 1 480 ? -39.592 -4.523  -71.45   1    54.756  ? 480  TYR B CE1   1 ? 
ATOM   8054  C  CE2   . TYR B 1 480 ? -38.792 -2.804  -69.981  1    51.286  ? 480  TYR B CE2   1 ? 
ATOM   8055  C  CZ    . TYR B 1 480 ? -39.769 -3.293  -70.837  1    54.46   ? 480  TYR B CZ    1 ? 
ATOM   8056  O  OH    . TYR B 1 480 ? -40.902 -2.56   -71.045  1    61.451  ? 480  TYR B OH    1 ? 
ATOM   8057  N  N     . TYR B 1 481 ? -36.274 -5.38   -66.962  1    38.563  ? 481  TYR B N     1 ? 
ATOM   8058  C  CA    . TYR B 1 481 ? -36.731 -4.795  -65.711  1    40.471  ? 481  TYR B CA    1 ? 
ATOM   8059  C  C     . TYR B 1 481 ? -37.241 -3.383  -66.009  1    38.056  ? 481  TYR B C     1 ? 
ATOM   8060  O  O     . TYR B 1 481 ? -36.449 -2.518  -66.372  1    35.344  ? 481  TYR B O     1 ? 
ATOM   8061  C  CB    . TYR B 1 481 ? -35.569 -4.756  -64.706  1    41.319  ? 481  TYR B CB    1 ? 
ATOM   8062  C  CG    . TYR B 1 481 ? -35.973 -4.147  -63.372  1    42.566  ? 481  TYR B CG    1 ? 
ATOM   8063  C  CD1   . TYR B 1 481 ? -36.773 -4.863  -62.482  1    45.579  ? 481  TYR B CD1   1 ? 
ATOM   8064  C  CD2   . TYR B 1 481 ? -35.568 -2.863  -63.005  1    42.789  ? 481  TYR B CD2   1 ? 
ATOM   8065  C  CE1   . TYR B 1 481 ? -37.168 -4.326  -61.266  1    43.122  ? 481  TYR B CE1   1 ? 
ATOM   8066  C  CE2   . TYR B 1 481 ? -35.969 -2.315  -61.791  1    42.704  ? 481  TYR B CE2   1 ? 
ATOM   8067  C  CZ    . TYR B 1 481 ? -36.762 -3.053  -60.921  1    42.556  ? 481  TYR B CZ    1 ? 
ATOM   8068  O  OH    . TYR B 1 481 ? -37.188 -2.547  -59.728  1    49.534  ? 481  TYR B OH    1 ? 
ATOM   8069  N  N     . PRO B 1 482 ? -38.564 -3.113  -65.889  1    40.203  ? 482  PRO B N     1 ? 
ATOM   8070  C  CA    . PRO B 1 482 ? -39.136 -1.856  -66.375  1    46.311  ? 482  PRO B CA    1 ? 
ATOM   8071  C  C     . PRO B 1 482 ? -39.138 -0.652  -65.427  1    49.016  ? 482  PRO B C     1 ? 
ATOM   8072  O  O     . PRO B 1 482 ? -40.111 0.102   -65.386  1    48.591  ? 482  PRO B O     1 ? 
ATOM   8073  C  CB    . PRO B 1 482 ? -40.561 -2.327  -66.731  1    47.4    ? 482  PRO B CB    1 ? 
ATOM   8074  C  CG    . PRO B 1 482 ? -40.893 -3.314  -65.635  1    49.127  ? 482  PRO B CG    1 ? 
ATOM   8075  C  CD    . PRO B 1 482 ? -39.577 -4.018  -65.301  1    42.335  ? 482  PRO B CD    1 ? 
ATOM   8076  N  N     . TYR B 1 483 ? -38.055 -0.467  -64.652  1    49.478  ? 483  TYR B N     1 ? 
ATOM   8077  C  CA    . TYR B 1 483 ? -37.952 0.723   -63.818  1    40.963  ? 483  TYR B CA    1 ? 
ATOM   8078  C  C     . TYR B 1 483 ? -36.5   1.179   -63.832  1    45.886  ? 483  TYR B C     1 ? 
ATOM   8079  O  O     . TYR B 1 483 ? -35.635 0.371   -64.144  1    40.91   ? 483  TYR B O     1 ? 
ATOM   8080  C  CB    . TYR B 1 483 ? -38.414 0.429   -62.391  1    41.722  ? 483  TYR B CB    1 ? 
ATOM   8081  C  CG    . TYR B 1 483 ? -39.759 -0.266  -62.266  1    40.131  ? 483  TYR B CG    1 ? 
ATOM   8082  C  CD1   . TYR B 1 483 ? -39.875 -1.634  -62.475  1    43.862  ? 483  TYR B CD1   1 ? 
ATOM   8083  C  CD2   . TYR B 1 483 ? -40.906 0.432   -61.903  1    44.38   ? 483  TYR B CD2   1 ? 
ATOM   8084  C  CE1   . TYR B 1 483 ? -41.092 -2.282  -62.33   1    49.594  ? 483  TYR B CE1   1 ? 
ATOM   8085  C  CE2   . TYR B 1 483 ? -42.135 -0.204  -61.774  1    48.32   ? 483  TYR B CE2   1 ? 
ATOM   8086  C  CZ    . TYR B 1 483 ? -42.224 -1.569  -61.978  1    49.629  ? 483  TYR B CZ    1 ? 
ATOM   8087  O  OH    . TYR B 1 483 ? -43.411 -2.23   -61.852  1    61.413  ? 483  TYR B OH    1 ? 
ATOM   8088  N  N     . HIS B 1 484 ? -36.237 2.463   -63.52   1    43.777  ? 484  HIS B N     1 ? 
ATOM   8089  C  CA    . HIS B 1 484 ? -34.857 2.928   -63.515  1    44.125  ? 484  HIS B CA    1 ? 
ATOM   8090  C  C     . HIS B 1 484 ? -34.117 2.529   -62.226  1    44.258  ? 484  HIS B C     1 ? 
ATOM   8091  O  O     . HIS B 1 484 ? -32.889 2.539   -62.2    1    42.769  ? 484  HIS B O     1 ? 
ATOM   8092  C  CB    . HIS B 1 484 ? -34.783 4.427   -63.829  1    47.658  ? 484  HIS B CB    1 ? 
ATOM   8093  C  CG    . HIS B 1 484 ? -35.277 4.734   -65.206  1    59.95   ? 484  HIS B CG    1 ? 
ATOM   8094  N  ND1   . HIS B 1 484 ? -34.533 4.455   -66.332  1    59.543  ? 484  HIS B ND1   1 ? 
ATOM   8095  C  CD2   . HIS B 1 484 ? -36.451 5.227   -65.644  1    60.796  ? 484  HIS B CD2   1 ? 
ATOM   8096  C  CE1   . HIS B 1 484 ? -35.232 4.796   -67.403  1    66.293  ? 484  HIS B CE1   1 ? 
ATOM   8097  N  NE2   . HIS B 1 484 ? -36.4   5.26    -67.01   1    63.412  ? 484  HIS B NE2   1 ? 
ATOM   8098  N  N     . TYR B 1 485 ? -34.847 2.17    -61.159  1    42.748  ? 485  TYR B N     1 ? 
ATOM   8099  C  CA    . TYR B 1 485 ? -34.205 1.886   -59.879  1    48.309  ? 485  TYR B CA    1 ? 
ATOM   8100  C  C     . TYR B 1 485 ? -34.821 0.653   -59.218  1    48.801  ? 485  TYR B C     1 ? 
ATOM   8101  O  O     . TYR B 1 485 ? -35.965 0.289   -59.503  1    45.75   ? 485  TYR B O     1 ? 
ATOM   8102  C  CB    . TYR B 1 485 ? -34.19  3.082   -58.912  1    45.793  ? 485  TYR B CB    1 ? 
ATOM   8103  C  CG    . TYR B 1 485 ? -33.215 4.196   -59.283  1    49.6    ? 485  TYR B CG    1 ? 
ATOM   8104  C  CD1   . TYR B 1 485 ? -31.836 4.025   -59.13   1    51.136  ? 485  TYR B CD1   1 ? 
ATOM   8105  C  CD2   . TYR B 1 485 ? -33.673 5.417   -59.778  1    46.474  ? 485  TYR B CD2   1 ? 
ATOM   8106  C  CE1   . TYR B 1 485 ? -30.949 5.042   -59.457  1    57.492  ? 485  TYR B CE1   1 ? 
ATOM   8107  C  CE2   . TYR B 1 485 ? -32.795 6.434   -60.122  1    48.736  ? 485  TYR B CE2   1 ? 
ATOM   8108  C  CZ    . TYR B 1 485 ? -31.433 6.246   -59.958  1    57.313  ? 485  TYR B CZ    1 ? 
ATOM   8109  O  OH    . TYR B 1 485 ? -30.563 7.245   -60.305  1    64.529  ? 485  TYR B OH    1 ? 
ATOM   8110  N  N     . ALA B 1 486 ? -34.026 0.031   -58.32   1    52.061  ? 486  ALA B N     1 ? 
ATOM   8111  C  CA    . ALA B 1 486 ? -34.456 -1.085  -57.482  1    45.08   ? 486  ALA B CA    1 ? 
ATOM   8112  C  C     . ALA B 1 486 ? -35.509 -0.591  -56.499  1    39.97   ? 486  ALA B C     1 ? 
ATOM   8113  O  O     . ALA B 1 486 ? -35.526 0.591   -56.16   1    45.389  ? 486  ALA B O     1 ? 
ATOM   8114  C  CB    . ALA B 1 486 ? -33.263 -1.673  -56.754  1    51.387  ? 486  ALA B CB    1 ? 
ATOM   8115  N  N     . PRO B 1 487 ? -36.416 -1.456  -55.991  1    40.407  ? 487  PRO B N     1 ? 
ATOM   8116  C  CA    . PRO B 1 487 ? -37.287 -1.055  -54.879  1    44.228  ? 487  PRO B CA    1 ? 
ATOM   8117  C  C     . PRO B 1 487 ? -36.432 -1.007  -53.611  1    46.954  ? 487  PRO B C     1 ? 
ATOM   8118  O  O     . PRO B 1 487 ? -35.292 -1.467  -53.62   1    47.915  ? 487  PRO B O     1 ? 
ATOM   8119  C  CB    . PRO B 1 487 ? -38.358 -2.163  -54.803  1    43.471  ? 487  PRO B CB    1 ? 
ATOM   8120  C  CG    . PRO B 1 487 ? -37.748 -3.348  -55.544  1    41.146  ? 487  PRO B CG    1 ? 
ATOM   8121  C  CD    . PRO B 1 487 ? -36.569 -2.871  -56.365  1    37.106  ? 487  PRO B CD    1 ? 
ATOM   8122  N  N     . PHE B 1 488 ? -36.973 -0.424  -52.533  1    52.234  ? 488  PHE B N     1 ? 
ATOM   8123  C  CA    . PHE B 1 488 ? -36.369 -0.52   -51.212  1    48.643  ? 488  PHE B CA    1 ? 
ATOM   8124  C  C     . PHE B 1 488 ? -36.517 -1.956  -50.732  1    49.545  ? 488  PHE B C     1 ? 
ATOM   8125  O  O     . PHE B 1 488 ? -37.628 -2.479  -50.801  1    47.444  ? 488  PHE B O     1 ? 
ATOM   8126  C  CB    . PHE B 1 488 ? -37.189 0.322   -50.228  1    56.036  ? 488  PHE B CB    1 ? 
ATOM   8127  C  CG    . PHE B 1 488 ? -36.887 1.809   -50.315  1    59.619  ? 488  PHE B CG    1 ? 
ATOM   8128  C  CD1   . PHE B 1 488 ? -37.585 2.626   -51.199  1    56.123  ? 488  PHE B CD1   1 ? 
ATOM   8129  C  CD2   . PHE B 1 488 ? -35.881 2.371   -49.531  1    68.545  ? 488  PHE B CD2   1 ? 
ATOM   8130  C  CE1   . PHE B 1 488 ? -37.278 3.967   -51.297  1    57.911  ? 488  PHE B CE1   1 ? 
ATOM   8131  C  CE2   . PHE B 1 488 ? -35.586 3.72    -49.62   1    66.358  ? 488  PHE B CE2   1 ? 
ATOM   8132  C  CZ    . PHE B 1 488 ? -36.283 4.511   -50.508  1    70.038  ? 488  PHE B CZ    1 ? 
ATOM   8133  N  N     . LEU B 1 489 ? -35.421 -2.55   -50.213  1    52.428  ? 489  LEU B N     1 ? 
ATOM   8134  C  CA    . LEU B 1 489 ? -35.407 -3.954  -49.806  1    58.256  ? 489  LEU B CA    1 ? 
ATOM   8135  C  C     . LEU B 1 489 ? -36.566 -4.243  -48.854  1    58.574  ? 489  LEU B C     1 ? 
ATOM   8136  O  O     . LEU B 1 489 ? -37.158 -5.319  -48.906  1    54.845  ? 489  LEU B O     1 ? 
ATOM   8137  C  CB    . LEU B 1 489 ? -34.101 -4.46   -49.189  1    56.268  ? 489  LEU B CB    1 ? 
ATOM   8138  C  CG    . LEU B 1 489 ? -32.805 -4.256  -49.979  1    66.999  ? 489  LEU B CG    1 ? 
ATOM   8139  C  CD1   . LEU B 1 489 ? -31.65  -4.519  -49.028  1    68.243  ? 489  LEU B CD1   1 ? 
ATOM   8140  C  CD2   . LEU B 1 489 ? -32.683 -5.125  -51.218  1    66.218  ? 489  LEU B CD2   1 ? 
ATOM   8141  N  N     . SER B 1 490 ? -36.848 -3.283  -47.963  1    64.634  ? 490  SER B N     1 ? 
ATOM   8142  C  CA    . SER B 1 490 ? -37.867 -3.41   -46.931  1    56.62   ? 490  SER B CA    1 ? 
ATOM   8143  C  C     . SER B 1 490 ? -39.247 -3.556  -47.558  1    62.685  ? 490  SER B C     1 ? 
ATOM   8144  O  O     . SER B 1 490 ? -40.211 -3.791  -46.838  1    63.122  ? 490  SER B O     1 ? 
ATOM   8145  C  CB    . SER B 1 490 ? -37.819 -2.239  -45.974  1    55.798  ? 490  SER B CB    1 ? 
ATOM   8146  O  OG    . SER B 1 490 ? -37.594 -1.013  -46.663  1    49.259  ? 490  SER B OG    1 ? 
ATOM   8147  N  N     . ASP B 1 491 ? -39.317 -3.432  -48.898  1    65.822  ? 491  ASP B N     1 ? 
ATOM   8148  C  CA    . ASP B 1 491 ? -40.564 -3.474  -49.655  1    64.742  ? 491  ASP B CA    1 ? 
ATOM   8149  C  C     . ASP B 1 491 ? -40.72  -4.787  -50.436  1    64.661  ? 491  ASP B C     1 ? 
ATOM   8150  O  O     . ASP B 1 491 ? -41.765 -5.021  -51.061  1    57.326  ? 491  ASP B O     1 ? 
ATOM   8151  C  CB    . ASP B 1 491 ? -40.704 -2.268  -50.572  1    68.876  ? 491  ASP B CB    1 ? 
ATOM   8152  C  CG    . ASP B 1 491 ? -41.429 -1.066  -49.989  1    70.577  ? 491  ASP B CG    1 ? 
ATOM   8153  O  OD1   . ASP B 1 491 ? -42.457 -1.277  -49.31   1    82.112  ? 491  ASP B OD1   1 ? 
ATOM   8154  O  OD2   . ASP B 1 491 ? -40.989 0.068   -50.266  1    67.269  ? 491  ASP B OD2   1 ? 
ATOM   8155  N  N     . ILE B 1 492 ? -39.689 -5.648  -50.38   1    60.741  ? 492  ILE B N     1 ? 
ATOM   8156  C  CA    . ILE B 1 492 ? -39.696 -6.922  -51.085  1    59.777  ? 492  ILE B CA    1 ? 
ATOM   8157  C  C     . ILE B 1 492 ? -40.112 -8.035  -50.122  1    65.866  ? 492  ILE B C     1 ? 
ATOM   8158  O  O     . ILE B 1 492 ? -39.298 -8.529  -49.334  1    66.937  ? 492  ILE B O     1 ? 
ATOM   8159  C  CB    . ILE B 1 492 ? -38.331 -7.181  -51.746  1    53.433  ? 492  ILE B CB    1 ? 
ATOM   8160  C  CG1   . ILE B 1 492 ? -37.924 -6.018  -52.63   1    48.707  ? 492  ILE B CG1   1 ? 
ATOM   8161  C  CG2   . ILE B 1 492 ? -38.352 -8.488  -52.538  1    52.813  ? 492  ILE B CG2   1 ? 
ATOM   8162  C  CD1   . ILE B 1 492 ? -36.434 -5.963  -52.92   1    57.524  ? 492  ILE B CD1   1 ? 
ATOM   8163  N  N     . HIS B 1 493 ? -41.395 -8.413  -50.203  1    63.941  ? 493  HIS B N     1 ? 
ATOM   8164  C  CA    . HIS B 1 493 ? -41.978 -9.427  -49.336  1    67.132  ? 493  HIS B CA    1 ? 
ATOM   8165  C  C     . HIS B 1 493 ? -43.288 -9.943  -49.943  1    70.338  ? 493  HIS B C     1 ? 
ATOM   8166  O  O     . HIS B 1 493 ? -43.883 -9.298  -50.812  1    56.914  ? 493  HIS B O     1 ? 
ATOM   8167  C  CB    . HIS B 1 493 ? -42.138 -8.883  -47.91   1    64.466  ? 493  HIS B CB    1 ? 
ATOM   8168  C  CG    . HIS B 1 493 ? -43.048 -7.698  -47.83   1    64.693  ? 493  HIS B CG    1 ? 
ATOM   8169  N  ND1   . HIS B 1 493 ? -42.601 -6.397  -47.749  1    65.56   ? 493  HIS B ND1   1 ? 
ATOM   8170  C  CD2   . HIS B 1 493 ? -44.385 -7.635  -47.826  1    61.841  ? 493  HIS B CD2   1 ? 
ATOM   8171  C  CE1   . HIS B 1 493 ? -43.643 -5.58   -47.691  1    65.899  ? 493  HIS B CE1   1 ? 
ATOM   8172  N  NE2   . HIS B 1 493 ? -44.736 -6.317  -47.749  1    64.866  ? 493  HIS B NE2   1 ? 
ATOM   8173  N  N     . ASN B 1 494 ? -43.735 -11.107 -49.447  1    61.522  ? 494  ASN B N     1 ? 
ATOM   8174  C  CA    . ASN B 1 494 ? -44.823 -11.859 -50.053  1    66.439  ? 494  ASN B CA    1 ? 
ATOM   8175  C  C     . ASN B 1 494 ? -44.373 -12.441 -51.392  1    66.43   ? 494  ASN B C     1 ? 
ATOM   8176  O  O     . ASN B 1 494 ? -45.174 -12.584 -52.314  1    79.813  ? 494  ASN B O     1 ? 
ATOM   8177  C  CB    . ASN B 1 494 ? -46.106 -11.041 -50.161  1    69.733  ? 494  ASN B CB    1 ? 
ATOM   8178  C  CG    . ASN B 1 494 ? -46.913 -11.094 -48.889  1    79.586  ? 494  ASN B CG    1 ? 
ATOM   8179  O  OD1   . ASN B 1 494 ? -46.403 -10.774 -47.809  1    85.485  ? 494  ASN B OD1   1 ? 
ATOM   8180  N  ND2   . ASN B 1 494 ? -48.164 -11.515 -48.995  1    88.248  ? 494  ASN B ND2   1 ? 
ATOM   8181  N  N     . ILE B 1 495 ? -43.095 -12.817 -51.474  1    60.278  ? 495  ILE B N     1 ? 
ATOM   8182  C  CA    . ILE B 1 495 ? -42.517 -13.254 -52.735  1    62.414  ? 495  ILE B CA    1 ? 
ATOM   8183  C  C     . ILE B 1 495 ? -42.265 -14.763 -52.724  1    63.706  ? 495  ILE B C     1 ? 
ATOM   8184  O  O     . ILE B 1 495 ? -41.706 -15.293 -53.69   1    51.82   ? 495  ILE B O     1 ? 
ATOM   8185  C  CB    . ILE B 1 495 ? -41.199 -12.508 -53.02   1    60.731  ? 495  ILE B CB    1 ? 
ATOM   8186  C  CG1   . ILE B 1 495 ? -40.161 -12.806 -51.934  1    62.581  ? 495  ILE B CG1   1 ? 
ATOM   8187  C  CG2   . ILE B 1 495 ? -41.439 -11.009 -53.203  1    66.029  ? 495  ILE B CG2   1 ? 
ATOM   8188  C  CD1   . ILE B 1 495 ? -38.724 -12.535 -52.328  1    62.178  ? 495  ILE B CD1   1 ? 
ATOM   8189  N  N     . SER B 1 496 ? -42.624 -15.444 -51.625  1    59.852  ? 496  SER B N     1 ? 
ATOM   8190  C  CA    . SER B 1 496 ? -42.063 -16.771 -51.409  1    61.859  ? 496  SER B CA    1 ? 
ATOM   8191  C  C     . SER B 1 496 ? -42.717 -17.808 -52.319  1    59.735  ? 496  SER B C     1 ? 
ATOM   8192  O  O     . SER B 1 496 ? -42.102 -18.835 -52.603  1    63.918  ? 496  SER B O     1 ? 
ATOM   8193  C  CB    . SER B 1 496 ? -42.017 -17.194 -49.947  1    60.186  ? 496  SER B CB    1 ? 
ATOM   8194  O  OG    . SER B 1 496 ? -43.299 -17.128 -49.341  1    68.925  ? 496  SER B OG    1 ? 
ATOM   8195  N  N     . THR B 1 497 ? -43.941 -17.519 -52.785  1    53.092  ? 497  THR B N     1 ? 
ATOM   8196  C  CA    . THR B 1 497 ? -44.644 -18.409 -53.701  1    67.43   ? 497  THR B CA    1 ? 
ATOM   8197  C  C     . THR B 1 497 ? -44.967 -17.683 -55.009  1    67.063  ? 497  THR B C     1 ? 
ATOM   8198  O  O     . THR B 1 497 ? -45.933 -18.025 -55.686  1    73.043  ? 497  THR B O     1 ? 
ATOM   8199  C  CB    . THR B 1 497 ? -45.912 -18.974 -53.055  1    79.568  ? 497  THR B CB    1 ? 
ATOM   8200  O  OG1   . THR B 1 497 ? -46.853 -17.902 -53.059  1    82.938  ? 497  THR B OG1   1 ? 
ATOM   8201  C  CG2   . THR B 1 497 ? -45.677 -19.542 -51.664  1    79.957  ? 497  THR B CG2   1 ? 
ATOM   8202  N  N     . LEU B 1 498 ? -44.144 -16.686 -55.354  1    73.149  ? 498  LEU B N     1 ? 
ATOM   8203  C  CA    . LEU B 1 498 ? -44.236 -15.945 -56.603  1    71.342  ? 498  LEU B CA    1 ? 
ATOM   8204  C  C     . LEU B 1 498 ? -43.9   -16.863 -57.778  1    70.876  ? 498  LEU B C     1 ? 
ATOM   8205  O  O     . LEU B 1 498 ? -42.976 -17.672 -57.702  1    73.997  ? 498  LEU B O     1 ? 
ATOM   8206  C  CB    . LEU B 1 498 ? -43.252 -14.786 -56.493  1    67.723  ? 498  LEU B CB    1 ? 
ATOM   8207  C  CG    . LEU B 1 498 ? -42.989 -13.986 -57.772  1    76.991  ? 498  LEU B CG    1 ? 
ATOM   8208  C  CD1   . LEU B 1 498 ? -44.198 -13.14  -58.156  1    72.669  ? 498  LEU B CD1   1 ? 
ATOM   8209  C  CD2   . LEU B 1 498 ? -41.73  -13.137 -57.6    1    76.989  ? 498  LEU B CD2   1 ? 
ATOM   8210  N  N     . LYS B 1 499 ? -44.655 -16.715 -58.869  1    69.388  ? 499  LYS B N     1 ? 
ATOM   8211  C  CA    . LYS B 1 499 ? -44.554 -17.613 -60.007  1    75.25   ? 499  LYS B CA    1 ? 
ATOM   8212  C  C     . LYS B 1 499 ? -43.711 -16.928 -61.08   1    72.985  ? 499  LYS B C     1 ? 
ATOM   8213  O  O     . LYS B 1 499 ? -44.099 -15.883 -61.605  1    74.003  ? 499  LYS B O     1 ? 
ATOM   8214  C  CB    . LYS B 1 499 ? -45.96  -18.067 -60.431  1    87.163  ? 499  LYS B CB    1 ? 
ATOM   8215  C  CG    . LYS B 1 499 ? -46.81  -18.653 -59.286  1    95.849  ? 499  LYS B CG    1 ? 
ATOM   8216  C  CD    . LYS B 1 499 ? -48.062 -19.441 -59.663  1    102.082 ? 499  LYS B CD    1 ? 
ATOM   8217  C  CE    . LYS B 1 499 ? -47.748 -20.794 -60.232  1    103.804 ? 499  LYS B CE    1 ? 
ATOM   8218  N  NZ    . LYS B 1 499 ? -48.875 -21.37  -60.97   1    99.437  ? 499  LYS B NZ    1 ? 
ATOM   8219  N  N     . ILE B 1 500 ? -42.541 -17.522 -61.355  1    67.054  ? 500  ILE B N     1 ? 
ATOM   8220  C  CA    . ILE B 1 500 ? -41.514 -16.942 -62.209  1    63.223  ? 500  ILE B CA    1 ? 
ATOM   8221  C  C     . ILE B 1 500 ? -41.384 -17.801 -63.461  1    68.568  ? 500  ILE B C     1 ? 
ATOM   8222  O  O     . ILE B 1 500 ? -40.699 -18.822 -63.456  1    73.093  ? 500  ILE B O     1 ? 
ATOM   8223  C  CB    . ILE B 1 500 ? -40.155 -16.843 -61.485  1    61.689  ? 500  ILE B CB    1 ? 
ATOM   8224  C  CG1   . ILE B 1 500 ? -40.195 -15.919 -60.241  1    58.217  ? 500  ILE B CG1   1 ? 
ATOM   8225  C  CG2   . ILE B 1 500 ? -39.048 -16.453 -62.467  1    60.587  ? 500  ILE B CG2   1 ? 
ATOM   8226  C  CD1   . ILE B 1 500 ? -38.858 -15.737 -59.532  1    46.099  ? 500  ILE B CD1   1 ? 
ATOM   8227  N  N     . HIS B 1 501 ? -42.021 -17.358 -64.545  1    77.824  ? 501  HIS B N     1 ? 
ATOM   8228  C  CA    . HIS B 1 501 ? -41.977 -18.107 -65.788  1    75.063  ? 501  HIS B CA    1 ? 
ATOM   8229  C  C     . HIS B 1 501 ? -41.357 -17.24  -66.884  1    62.811  ? 501  HIS B C     1 ? 
ATOM   8230  O  O     . HIS B 1 501 ? -41.833 -16.138 -67.153  1    64.191  ? 501  HIS B O     1 ? 
ATOM   8231  C  CB    . HIS B 1 501 ? -43.375 -18.643 -66.117  1    86.782  ? 501  HIS B CB    1 ? 
ATOM   8232  C  CG    . HIS B 1 501 ? -43.337 -19.942 -66.848  1    99.579  ? 501  HIS B CG    1 ? 
ATOM   8233  N  ND1   . HIS B 1 501 ? -43.025 -20.044 -68.188  1    101.395 ? 501  HIS B ND1   1 ? 
ATOM   8234  C  CD2   . HIS B 1 501 ? -43.544 -21.192 -66.412  1    100.928 ? 501  HIS B CD2   1 ? 
ATOM   8235  C  CE1   . HIS B 1 501 ? -43.062 -21.32  -68.547  1    109.066 ? 501  HIS B CE1   1 ? 
ATOM   8236  N  NE2   . HIS B 1 501 ? -43.38  -22.034 -67.484  1    110.906 ? 501  HIS B NE2   1 ? 
ATOM   8237  N  N     . PHE B 1 502 ? -40.286 -17.75  -67.505  1    49.338  ? 502  PHE B N     1 ? 
ATOM   8238  C  CA    . PHE B 1 502 ? -39.614 -17.056 -68.598  1    46.234  ? 502  PHE B CA    1 ? 
ATOM   8239  C  C     . PHE B 1 502 ? -39.917 -17.747 -69.926  1    49.92   ? 502  PHE B C     1 ? 
ATOM   8240  O  O     . PHE B 1 502 ? -39.978 -18.977 -69.994  1    48.423  ? 502  PHE B O     1 ? 
ATOM   8241  C  CB    . PHE B 1 502 ? -38.093 -16.938 -68.404  1    42.26   ? 502  PHE B CB    1 ? 
ATOM   8242  C  CG    . PHE B 1 502 ? -37.677 -16.044 -67.241  1    45.787  ? 502  PHE B CG    1 ? 
ATOM   8243  C  CD1   . PHE B 1 502 ? -37.908 -14.662 -67.277  1    45.727  ? 502  PHE B CD1   1 ? 
ATOM   8244  C  CD2   . PHE B 1 502 ? -37.048 -16.581 -66.117  1    44.375  ? 502  PHE B CD2   1 ? 
ATOM   8245  C  CE1   . PHE B 1 502 ? -37.547 -13.843 -66.211  1    44.16   ? 502  PHE B CE1   1 ? 
ATOM   8246  C  CE2   . PHE B 1 502 ? -36.673 -15.755 -65.06   1    44.229  ? 502  PHE B CE2   1 ? 
ATOM   8247  C  CZ    . PHE B 1 502 ? -36.931 -14.396 -65.101  1    45.141  ? 502  PHE B CZ    1 ? 
ATOM   8248  N  N     . GLU B 1 503 ? -40.08  -16.931 -70.979  1    50.888  ? 503  GLU B N     1 ? 
ATOM   8249  C  CA    . GLU B 1 503 ? -40.12  -17.382 -72.362  1    47.199  ? 503  GLU B CA    1 ? 
ATOM   8250  C  C     . GLU B 1 503 ? -38.758 -17.127 -72.998  1    44.903  ? 503  GLU B C     1 ? 
ATOM   8251  O  O     . GLU B 1 503 ? -38.292 -15.99  -73.013  1    37.388  ? 503  GLU B O     1 ? 
ATOM   8252  C  CB    . GLU B 1 503 ? -41.103 -16.478 -73.109  1    62.222  ? 503  GLU B CB    1 ? 
ATOM   8253  C  CG    . GLU B 1 503 ? -42.563 -16.687 -72.712  1    75.62   ? 503  GLU B CG    1 ? 
ATOM   8254  C  CD    . GLU B 1 503 ? -43.045 -18.083 -73.065  1    87.849  ? 503  GLU B CD    1 ? 
ATOM   8255  O  OE1   . GLU B 1 503 ? -43.051 -18.409 -74.272  1    93.639  ? 503  GLU B OE1   1 ? 
ATOM   8256  O  OE2   . GLU B 1 503 ? -43.39  -18.854 -72.141  1    94.638  ? 503  GLU B OE2   1 ? 
ATOM   8257  N  N     . LEU B 1 504 ? -38.132 -18.168 -73.555  1    37.104  ? 504  LEU B N     1 ? 
ATOM   8258  C  CA    . LEU B 1 504 ? -36.819 -17.985 -74.147  1    45.899  ? 504  LEU B CA    1 ? 
ATOM   8259  C  C     . LEU B 1 504 ? -36.817 -16.9   -75.242  1    47.743  ? 504  LEU B C     1 ? 
ATOM   8260  O  O     . LEU B 1 504 ? -35.871 -16.115 -75.335  1    45.924  ? 504  LEU B O     1 ? 
ATOM   8261  C  CB    . LEU B 1 504 ? -36.237 -19.321 -74.608  1    46.532  ? 504  LEU B CB    1 ? 
ATOM   8262  C  CG    . LEU B 1 504 ? -34.818 -19.267 -75.187  1    46.774  ? 504  LEU B CG    1 ? 
ATOM   8263  C  CD1   . LEU B 1 504 ? -33.788 -18.736 -74.199  1    42.904  ? 504  LEU B CD1   1 ? 
ATOM   8264  C  CD2   . LEU B 1 504 ? -34.412 -20.635 -75.685  1    44.982  ? 504  LEU B CD2   1 ? 
ATOM   8265  N  N     . GLY B 1 505 ? -37.861 -16.851 -76.084  1    46.397  ? 505  GLY B N     1 ? 
ATOM   8266  C  CA    . GLY B 1 505 ? -37.887 -15.931 -77.211  1    39.183  ? 505  GLY B CA    1 ? 
ATOM   8267  C  C     . GLY B 1 505 ? -36.651 -16.111 -78.091  1    36.396  ? 505  GLY B C     1 ? 
ATOM   8268  O  O     . GLY B 1 505 ? -36.116 -17.21  -78.192  1    40.373  ? 505  GLY B O     1 ? 
ATOM   8269  N  N     . LYS B 1 506 ? -36.164 -15.024 -78.706  1    34.745  ? 506  LYS B N     1 ? 
ATOM   8270  C  CA    . LYS B 1 506 ? -35.01  -15.133 -79.592  1    36.297  ? 506  LYS B CA    1 ? 
ATOM   8271  C  C     . LYS B 1 506 ? -34.332 -13.773 -79.708  1    31.445  ? 506  LYS B C     1 ? 
ATOM   8272  O  O     . LYS B 1 506 ? -34.944 -12.752 -79.412  1    30.77   ? 506  LYS B O     1 ? 
ATOM   8273  C  CB    . LYS B 1 506 ? -35.391 -15.641 -80.995  1    47.457  ? 506  LYS B CB    1 ? 
ATOM   8274  C  CG    . LYS B 1 506 ? -36.411 -14.799 -81.762  1    56.286  ? 506  LYS B CG    1 ? 
ATOM   8275  C  CD    . LYS B 1 506 ? -36.95  -15.408 -83.057  1    72.05   ? 506  LYS B CD    1 ? 
ATOM   8276  C  CE    . LYS B 1 506 ? -38.031 -16.437 -82.842  1    83.556  ? 506  LYS B CE    1 ? 
ATOM   8277  N  NZ    . LYS B 1 506 ? -38.609 -16.911 -84.105  1    81.154  ? 506  LYS B NZ    1 ? 
ATOM   8278  N  N     . PRO B 1 507 ? -33.047 -13.727 -80.12   1    28.69   ? 507  PRO B N     1 ? 
ATOM   8279  C  CA    . PRO B 1 507 ? -32.342 -12.452 -80.264  1    33.83   ? 507  PRO B CA    1 ? 
ATOM   8280  C  C     . PRO B 1 507 ? -32.962 -11.546 -81.338  1    39.105  ? 507  PRO B C     1 ? 
ATOM   8281  O  O     . PRO B 1 507 ? -33.476 -12.022 -82.353  1    37.96   ? 507  PRO B O     1 ? 
ATOM   8282  C  CB    . PRO B 1 507 ? -30.858 -12.819 -80.566  1    30.238  ? 507  PRO B CB    1 ? 
ATOM   8283  C  CG    . PRO B 1 507 ? -30.797 -14.347 -80.586  1    29.107  ? 507  PRO B CG    1 ? 
ATOM   8284  C  CD    . PRO B 1 507 ? -32.193 -14.904 -80.381  1    29.986  ? 507  PRO B CD    1 ? 
ATOM   8285  N  N     . PHE B 1 508 ? -32.857 -10.229 -81.138  1    36.638  ? 508  PHE B N     1 ? 
ATOM   8286  C  CA    . PHE B 1 508 ? -33.202 -9.277  -82.185  1    35.788  ? 508  PHE B CA    1 ? 
ATOM   8287  C  C     . PHE B 1 508 ? -32.289 -9.463  -83.392  1    34.427  ? 508  PHE B C     1 ? 
ATOM   8288  O  O     . PHE B 1 508 ? -31.13  -9.824  -83.234  1    37.235  ? 508  PHE B O     1 ? 
ATOM   8289  C  CB    . PHE B 1 508 ? -32.986 -7.857  -81.642  1    39.314  ? 508  PHE B CB    1 ? 
ATOM   8290  C  CG    . PHE B 1 508 ? -34.227 -7.218  -81.035  1    42.072  ? 508  PHE B CG    1 ? 
ATOM   8291  C  CD1   . PHE B 1 508 ? -35.446 -7.894  -81.033  1    43.614  ? 508  PHE B CD1   1 ? 
ATOM   8292  C  CD2   . PHE B 1 508 ? -34.186 -5.912  -80.544  1    43.929  ? 508  PHE B CD2   1 ? 
ATOM   8293  C  CE1   . PHE B 1 508 ? -36.591 -7.29   -80.518  1    50.017  ? 508  PHE B CE1   1 ? 
ATOM   8294  C  CE2   . PHE B 1 508 ? -35.325 -5.312  -80.018  1    42.268  ? 508  PHE B CE2   1 ? 
ATOM   8295  C  CZ    . PHE B 1 508 ? -36.526 -6.006  -80.001  1    45.437  ? 508  PHE B CZ    1 ? 
ATOM   8296  N  N     . LYS B 1 509 ? -32.782 -9.126  -84.594  1    34.184  ? 509  LYS B N     1 ? 
ATOM   8297  C  CA    . LYS B 1 509 ? -31.894 -8.963  -85.731  1    34.665  ? 509  LYS B CA    1 ? 
ATOM   8298  C  C     . LYS B 1 509 ? -31.058 -7.724  -85.438  1    36.24   ? 509  LYS B C     1 ? 
ATOM   8299  O  O     . LYS B 1 509 ? -31.569 -6.814  -84.788  1    40.936  ? 509  LYS B O     1 ? 
ATOM   8300  C  CB    . LYS B 1 509 ? -32.705 -8.708  -87.018  1    40.618  ? 509  LYS B CB    1 ? 
ATOM   8301  C  CG    . LYS B 1 509 ? -33.779 -9.737  -87.406  1    51.986  ? 509  LYS B CG    1 ? 
ATOM   8302  C  CD    . LYS B 1 509 ? -34.457 -9.428  -88.746  1    60.186  ? 509  LYS B CD    1 ? 
ATOM   8303  C  CE    . LYS B 1 509 ? -35.625 -10.295 -89.134  1    59.834  ? 509  LYS B CE    1 ? 
ATOM   8304  N  NZ    . LYS B 1 509 ? -36.679 -10.253 -88.115  1    67.107  ? 509  LYS B NZ    1 ? 
ATOM   8305  N  N     . PRO B 1 510 ? -29.791 -7.629  -85.915  1    32.715  ? 510  PRO B N     1 ? 
ATOM   8306  C  CA    . PRO B 1 510 ? -28.941 -6.474  -85.63   1    35.26   ? 510  PRO B CA    1 ? 
ATOM   8307  C  C     . PRO B 1 510 ? -29.577 -5.077  -85.724  1    40.952  ? 510  PRO B C     1 ? 
ATOM   8308  O  O     . PRO B 1 510 ? -29.328 -4.23   -84.855  1    35.567  ? 510  PRO B O     1 ? 
ATOM   8309  C  CB    . PRO B 1 510 ? -27.746 -6.65   -86.601  1    40.427  ? 510  PRO B CB    1 ? 
ATOM   8310  C  CG    . PRO B 1 510 ? -27.678 -8.148  -86.858  1    38.647  ? 510  PRO B CG    1 ? 
ATOM   8311  C  CD    . PRO B 1 510 ? -29.11  -8.647  -86.733  1    33.562  ? 510  PRO B CD    1 ? 
ATOM   8312  N  N     . PHE B 1 511 ? -30.395 -4.843  -86.767  1    34.674  ? 511  PHE B N     1 ? 
ATOM   8313  C  CA    . PHE B 1 511 ? -30.943 -3.519  -87.048  1    36.622  ? 511  PHE B CA    1 ? 
ATOM   8314  C  C     . PHE B 1 511 ? -32.054 -3.182  -86.047  1    34.352  ? 511  PHE B C     1 ? 
ATOM   8315  O  O     . PHE B 1 511 ? -32.246 -2.018  -85.712  1    35.068  ? 511  PHE B O     1 ? 
ATOM   8316  C  CB    . PHE B 1 511 ? -31.383 -3.311  -88.511  1    32.048  ? 511  PHE B CB    1 ? 
ATOM   8317  C  CG    . PHE B 1 511 ? -30.267 -3.395  -89.551  1    33.994  ? 511  PHE B CG    1 ? 
ATOM   8318  C  CD1   . PHE B 1 511 ? -28.964 -3.022  -89.241  1    33.52   ? 511  PHE B CD1   1 ? 
ATOM   8319  C  CD2   . PHE B 1 511 ? -30.52  -3.853  -90.842  1    32.869  ? 511  PHE B CD2   1 ? 
ATOM   8320  C  CE1   . PHE B 1 511 ? -27.943 -3.077  -90.183  1    36.837  ? 511  PHE B CE1   1 ? 
ATOM   8321  C  CE2   . PHE B 1 511 ? -29.498 -3.92   -91.78   1    29.192  ? 511  PHE B CE2   1 ? 
ATOM   8322  C  CZ    . PHE B 1 511 ? -28.211 -3.531  -91.46   1    33.044  ? 511  PHE B CZ    1 ? 
ATOM   8323  N  N     . GLU B 1 512 ? -32.836 -4.184  -85.637  1    33.561  ? 512  GLU B N     1 ? 
ATOM   8324  C  CA    . GLU B 1 512 ? -33.821 -4.006  -84.587  1    35.907  ? 512  GLU B CA    1 ? 
ATOM   8325  C  C     . GLU B 1 512 ? -33.059 -3.569  -83.336  1    38.63   ? 512  GLU B C     1 ? 
ATOM   8326  O  O     . GLU B 1 512 ? -33.454 -2.621  -82.649  1    33.538  ? 512  GLU B O     1 ? 
ATOM   8327  C  CB    . GLU B 1 512 ? -34.584 -5.309  -84.329  1    41.024  ? 512  GLU B CB    1 ? 
ATOM   8328  C  CG    . GLU B 1 512 ? -35.245 -5.884  -85.579  1    46.222  ? 512  GLU B CG    1 ? 
ATOM   8329  C  CD    . GLU B 1 512 ? -35.841 -7.286  -85.527  1    46.499  ? 512  GLU B CD    1 ? 
ATOM   8330  O  OE1   . GLU B 1 512 ? -35.655 -8.017  -84.526  1    44.284  ? 512  GLU B OE1   1 ? 
ATOM   8331  O  OE2   . GLU B 1 512 ? -36.525 -7.643  -86.514  1    47.694  ? 512  GLU B OE2   1 ? 
ATOM   8332  N  N     . GLN B 1 513 ? -31.919 -4.229  -83.105  1    35.604  ? 513  GLN B N     1 ? 
ATOM   8333  C  CA    . GLN B 1 513 ? -31.07  -3.93   -81.957  1    38.394  ? 513  GLN B CA    1 ? 
ATOM   8334  C  C     . GLN B 1 513 ? -30.555 -2.49   -82.054  1    37.974  ? 513  GLN B C     1 ? 
ATOM   8335  O  O     . GLN B 1 513 ? -30.636 -1.751  -81.086  1    35.79   ? 513  GLN B O     1 ? 
ATOM   8336  C  CB    . GLN B 1 513 ? -29.982 -4.995  -81.792  1    34.981  ? 513  GLN B CB    1 ? 
ATOM   8337  C  CG    . GLN B 1 513 ? -28.962 -4.743  -80.686  1    37.784  ? 513  GLN B CG    1 ? 
ATOM   8338  C  CD    . GLN B 1 513 ? -27.558 -4.451  -81.178  1    44.818  ? 513  GLN B CD    1 ? 
ATOM   8339  O  OE1   . GLN B 1 513 ? -26.605 -4.471  -80.376  1    39.619  ? 513  GLN B OE1   1 ? 
ATOM   8340  N  NE2   . GLN B 1 513 ? -27.408 -4.163  -82.48   1    36.327  ? 513  GLN B NE2   1 ? 
ATOM   8341  N  N     . LEU B 1 514 ? -30.026 -2.108  -83.217  1    39.505  ? 514  LEU B N     1 ? 
ATOM   8342  C  CA    . LEU B 1 514 ? -29.514 -0.763  -83.45   1    42.563  ? 514  LEU B CA    1 ? 
ATOM   8343  C  C     . LEU B 1 514 ? -30.531 0.318   -83.088  1    41.451  ? 514  LEU B C     1 ? 
ATOM   8344  O  O     . LEU B 1 514 ? -30.192 1.304   -82.442  1    42.91   ? 514  LEU B O     1 ? 
ATOM   8345  C  CB    . LEU B 1 514 ? -29.077 -0.605  -84.895  1    38.125  ? 514  LEU B CB    1 ? 
ATOM   8346  C  CG    . LEU B 1 514 ? -27.722 -1.229  -85.204  1    32.742  ? 514  LEU B CG    1 ? 
ATOM   8347  C  CD1   . LEU B 1 514 ? -27.213 -0.541  -86.441  1    39.584  ? 514  LEU B CD1   1 ? 
ATOM   8348  C  CD2   . LEU B 1 514 ? -26.818 -0.928  -84.082  1    32.104  ? 514  LEU B CD2   1 ? 
ATOM   8349  N  N     . LEU B 1 515 ? -31.778 0.117   -83.492  1    37.334  ? 515  LEU B N     1 ? 
ATOM   8350  C  CA    . LEU B 1 515 ? -32.801 1.107   -83.253  1    37.692  ? 515  LEU B CA    1 ? 
ATOM   8351  C  C     . LEU B 1 515 ? -33.171 1.115   -81.777  1    41.308  ? 515  LEU B C     1 ? 
ATOM   8352  O  O     . LEU B 1 515 ? -33.671 2.114   -81.266  1    43.505  ? 515  LEU B O     1 ? 
ATOM   8353  C  CB    . LEU B 1 515 ? -33.949 0.647   -84.14   1    39.463  ? 515  LEU B CB    1 ? 
ATOM   8354  C  CG    . LEU B 1 515 ? -34.779 1.737   -84.819  1    44.135  ? 515  LEU B CG    1 ? 
ATOM   8355  C  CD1   . LEU B 1 515 ? -33.982 2.942   -85.275  1    39.041  ? 515  LEU B CD1   1 ? 
ATOM   8356  C  CD2   . LEU B 1 515 ? -35.379 1.072   -86.022  1    43.692  ? 515  LEU B CD2   1 ? 
ATOM   8357  N  N     . ALA B 1 516 ? -32.899 0.005   -81.088  1    37.593  ? 516  ALA B N     1 ? 
ATOM   8358  C  CA    . ALA B 1 516 ? -33.278 -0.112  -79.685  1    41.378  ? 516  ALA B CA    1 ? 
ATOM   8359  C  C     . ALA B 1 516 ? -32.188 0.399   -78.735  1    46.097  ? 516  ALA B C     1 ? 
ATOM   8360  O  O     . ALA B 1 516 ? -32.421 0.46    -77.523  1    49.703  ? 516  ALA B O     1 ? 
ATOM   8361  C  CB    . ALA B 1 516 ? -33.719 -1.524  -79.342  1    34.486  ? 516  ALA B CB    1 ? 
ATOM   8362  N  N     . VAL B 1 517 ? -31.013 0.775   -79.265  1    38.578  ? 517  VAL B N     1 ? 
ATOM   8363  C  CA    . VAL B 1 517 ? -29.897 1.131   -78.395  1    38.602  ? 517  VAL B CA    1 ? 
ATOM   8364  C  C     . VAL B 1 517 ? -29.308 2.494   -78.765  1    37.449  ? 517  VAL B C     1 ? 
ATOM   8365  O  O     . VAL B 1 517 ? -28.592 3.059   -77.945  1    36.004  ? 517  VAL B O     1 ? 
ATOM   8366  C  CB    . VAL B 1 517 ? -28.757 0.094   -78.249  1    35.814  ? 517  VAL B CB    1 ? 
ATOM   8367  C  CG1   . VAL B 1 517 ? -29.231 -1.247  -77.69   1    31.902  ? 517  VAL B CG1   1 ? 
ATOM   8368  C  CG2   . VAL B 1 517 ? -27.952 -0.075  -79.528  1    34.828  ? 517  VAL B CG2   1 ? 
ATOM   8369  N  N     . LEU B 1 518 ? -29.605 3.01    -79.977  1    36.37   ? 518  LEU B N     1 ? 
ATOM   8370  C  CA    . LEU B 1 518 ? -28.95  4.204   -80.495  1    40.199  ? 518  LEU B CA    1 ? 
ATOM   8371  C  C     . LEU B 1 518 ? -29.776 5.484   -80.288  1    41.796  ? 518  LEU B C     1 ? 
ATOM   8372  O  O     . LEU B 1 518 ? -30.995 5.485   -80.419  1    41.892  ? 518  LEU B O     1 ? 
ATOM   8373  C  CB    . LEU B 1 518 ? -28.592 4.014   -81.964  1    37.38   ? 518  LEU B CB    1 ? 
ATOM   8374  C  CG    . LEU B 1 518 ? -27.349 3.176   -82.263  1    37.982  ? 518  LEU B CG    1 ? 
ATOM   8375  C  CD1   . LEU B 1 518 ? -27.193 3.139   -83.773  1    29.957  ? 518  LEU B CD1   1 ? 
ATOM   8376  C  CD2   . LEU B 1 518 ? -26.088 3.737   -81.606  1    32.438  ? 518  LEU B CD2   1 ? 
ATOM   8377  N  N     . PRO B 1 519 ? -29.133 6.643   -79.998  1    40.813  ? 519  PRO B N     1 ? 
ATOM   8378  C  CA    . PRO B 1 519 ? -29.842 7.927   -80.029  1    40.945  ? 519  PRO B CA    1 ? 
ATOM   8379  C  C     . PRO B 1 519 ? -29.91  8.49    -81.448  1    42.565  ? 519  PRO B C     1 ? 
ATOM   8380  O  O     . PRO B 1 519 ? -29.107 8.12    -82.309  1    41.692  ? 519  PRO B O     1 ? 
ATOM   8381  C  CB    . PRO B 1 519 ? -28.94  8.777   -79.143  1    40.387  ? 519  PRO B CB    1 ? 
ATOM   8382  C  CG    . PRO B 1 519 ? -27.542 8.293   -79.518  1    38.88   ? 519  PRO B CG    1 ? 
ATOM   8383  C  CD    . PRO B 1 519 ? -27.705 6.766   -79.632  1    36.492  ? 519  PRO B CD    1 ? 
ATOM   8384  N  N     . ALA B 1 520 ? -30.816 9.451   -81.661  1    41.86   ? 520  ALA B N     1 ? 
ATOM   8385  C  CA    . ALA B 1 520 ? -30.954 10.126  -82.948  1    39.268  ? 520  ALA B CA    1 ? 
ATOM   8386  C  C     . ALA B 1 520 ? -29.628 10.734  -83.387  1    39.288  ? 520  ALA B C     1 ? 
ATOM   8387  O  O     . ALA B 1 520 ? -29.346 10.802  -84.575  1    43.568  ? 520  ALA B O     1 ? 
ATOM   8388  C  CB    . ALA B 1 520 ? -32.039 11.166  -82.891  1    34.853  ? 520  ALA B CB    1 ? 
ATOM   8389  N  N     . ALA B 1 521 ? -28.787 11.134  -82.432  1    38.108  ? 521  ALA B N     1 ? 
ATOM   8390  C  CA    . ALA B 1 521 ? -27.511 11.725  -82.814  1    43.653  ? 521  ALA B CA    1 ? 
ATOM   8391  C  C     . ALA B 1 521 ? -26.633 10.718  -83.567  1    44.149  ? 521  ALA B C     1 ? 
ATOM   8392  O  O     . ALA B 1 521 ? -25.655 11.109  -84.192  1    37.458  ? 521  ALA B O     1 ? 
ATOM   8393  C  CB    . ALA B 1 521 ? -26.807 12.255  -81.583  1    43.727  ? 521  ALA B CB    1 ? 
ATOM   8394  N  N     . SER B 1 522 ? -26.974 9.417   -83.48   1    44.444  ? 522  SER B N     1 ? 
ATOM   8395  C  CA    . SER B 1 522 ? -26.168 8.361   -84.078  1    43.251  ? 522  SER B CA    1 ? 
ATOM   8396  C  C     . SER B 1 522 ? -26.858 7.755   -85.309  1    46.497  ? 522  SER B C     1 ? 
ATOM   8397  O  O     . SER B 1 522 ? -26.431 6.708   -85.811  1    45.669  ? 522  SER B O     1 ? 
ATOM   8398  C  CB    . SER B 1 522 ? -25.796 7.308   -83.028  1    37.436  ? 522  SER B CB    1 ? 
ATOM   8399  O  OG    . SER B 1 522 ? -24.674 7.721   -82.24   1    38.6    ? 522  SER B OG    1 ? 
ATOM   8400  N  N     . LYS B 1 523 ? -27.912 8.421   -85.809  1    40.479  ? 523  LYS B N     1 ? 
ATOM   8401  C  CA    . LYS B 1 523 ? -28.808 7.851   -86.814  1    47.156  ? 523  LYS B CA    1 ? 
ATOM   8402  C  C     . LYS B 1 523 ? -28.045 7.366   -88.052  1    42.123  ? 523  LYS B C     1 ? 
ATOM   8403  O  O     . LYS B 1 523 ? -28.519 6.462   -88.724  1    41.047  ? 523  LYS B O     1 ? 
ATOM   8404  C  CB    . LYS B 1 523 ? -29.944 8.785   -87.262  1    47.847  ? 523  LYS B CB    1 ? 
ATOM   8405  C  CG    . LYS B 1 523 ? -29.507 10.103  -87.911  1    48.004  ? 523  LYS B CG    1 ? 
ATOM   8406  C  CD    . LYS B 1 523 ? -30.56  10.614  -88.893  1    60.742  ? 523  LYS B CD    1 ? 
ATOM   8407  C  CE    . LYS B 1 523 ? -30.338 11.982  -89.48   1    64.509  ? 523  LYS B CE    1 ? 
ATOM   8408  N  NZ    . LYS B 1 523 ? -29.034 12.061  -90.137  1    65.298  ? 523  LYS B NZ    1 ? 
ATOM   8409  N  N     . ASN B 1 524 ? -26.885 7.97    -88.349  1    36.71   ? 524  ASN B N     1 ? 
ATOM   8410  C  CA    . ASN B 1 524 ? -26.093 7.663   -89.537  1    44.501  ? 524  ASN B CA    1 ? 
ATOM   8411  C  C     . ASN B 1 524 ? -25.525 6.248   -89.494  1    42.537  ? 524  ASN B C     1 ? 
ATOM   8412  O  O     . ASN B 1 524 ? -24.998 5.763   -90.494  1    42.762  ? 524  ASN B O     1 ? 
ATOM   8413  C  CB    . ASN B 1 524 ? -24.928 8.628   -89.734  1    46.439  ? 524  ASN B CB    1 ? 
ATOM   8414  C  CG    . ASN B 1 524 ? -25.349 9.833   -90.539  1    67.814  ? 524  ASN B CG    1 ? 
ATOM   8415  O  OD1   . ASN B 1 524 ? -26.533 9.972   -90.893  1    61.552  ? 524  ASN B OD1   1 ? 
ATOM   8416  N  ND2   . ASN B 1 524 ? -24.397 10.71   -90.837  1    69.469  ? 524  ASN B ND2   1 ? 
ATOM   8417  N  N     . LEU B 1 525 ? -25.638 5.596   -88.334  1    40.958  ? 525  LEU B N     1 ? 
ATOM   8418  C  CA    . LEU B 1 525 ? -25.087 4.269   -88.147  1    36.212  ? 525  LEU B CA    1 ? 
ATOM   8419  C  C     . LEU B 1 525 ? -26.073 3.246   -88.707  1    37.632  ? 525  LEU B C     1 ? 
ATOM   8420  O  O     . LEU B 1 525 ? -25.707 2.106   -89.003  1    37.434  ? 525  LEU B O     1 ? 
ATOM   8421  C  CB    . LEU B 1 525 ? -24.757 4.068   -86.664  1    32.82   ? 525  LEU B CB    1 ? 
ATOM   8422  C  CG    . LEU B 1 525 ? -23.578 4.898   -86.129  1    32.82   ? 525  LEU B CG    1 ? 
ATOM   8423  C  CD1   . LEU B 1 525 ? -23.249 4.552   -84.674  1    34.083  ? 525  LEU B CD1   1 ? 
ATOM   8424  C  CD2   . LEU B 1 525 ? -22.301 4.814   -86.965  1    30.193  ? 525  LEU B CD2   1 ? 
ATOM   8425  N  N     . LEU B 1 526 ? -27.314 3.689   -88.884  1    29.867  ? 526  LEU B N     1 ? 
ATOM   8426  C  CA    . LEU B 1 526 ? -28.374 2.838   -89.378  1    36.581  ? 526  LEU B CA    1 ? 
ATOM   8427  C  C     . LEU B 1 526 ? -28.477 2.914   -90.897  1    41.86   ? 526  LEU B C     1 ? 
ATOM   8428  O  O     . LEU B 1 526 ? -27.974 3.851   -91.52   1    41.251  ? 526  LEU B O     1 ? 
ATOM   8429  C  CB    . LEU B 1 526 ? -29.682 3.296   -88.747  1    34.172  ? 526  LEU B CB    1 ? 
ATOM   8430  C  CG    . LEU B 1 526 ? -29.904 2.807   -87.313  1    41.906  ? 526  LEU B CG    1 ? 
ATOM   8431  C  CD1   . LEU B 1 526 ? -30.657 3.885   -86.584  1    44.639  ? 526  LEU B CD1   1 ? 
ATOM   8432  C  CD2   . LEU B 1 526 ? -30.663 1.483   -87.345  1    41.258  ? 526  LEU B CD2   1 ? 
ATOM   8433  N  N     . PRO B 1 527 ? -29.177 1.945   -91.522  1    41.953  ? 527  PRO B N     1 ? 
ATOM   8434  C  CA    . PRO B 1 527 ? -29.565 2.075   -92.929  1    45.245  ? 527  PRO B CA    1 ? 
ATOM   8435  C  C     . PRO B 1 527 ? -30.52  3.261   -93.08   1    49.01   ? 527  PRO B C     1 ? 
ATOM   8436  O  O     . PRO B 1 527 ? -31.376 3.512   -92.213  1    43.26   ? 527  PRO B O     1 ? 
ATOM   8437  C  CB    . PRO B 1 527 ? -30.251 0.738   -93.223  1    40.001  ? 527  PRO B CB    1 ? 
ATOM   8438  C  CG    . PRO B 1 527 ? -29.749 -0.195  -92.13   1    43.776  ? 527  PRO B CG    1 ? 
ATOM   8439  C  CD    . PRO B 1 527 ? -29.656 0.691   -90.913  1    41.32   ? 527  PRO B CD    1 ? 
ATOM   8440  N  N     . ALA B 1 528 ? -30.356 3.961   -94.211  1    45.148  ? 528  ALA B N     1 ? 
ATOM   8441  C  CA    . ALA B 1 528 ? -31.195 5.074   -94.635  1    44.17   ? 528  ALA B CA    1 ? 
ATOM   8442  C  C     . ALA B 1 528 ? -32.676 4.805   -94.374  1    39.834  ? 528  ALA B C     1 ? 
ATOM   8443  O  O     . ALA B 1 528 ? -33.399 5.701   -93.93   1    46.521  ? 528  ALA B O     1 ? 
ATOM   8444  C  CB    . ALA B 1 528 ? -30.932 5.388   -96.108  1    47.419  ? 528  ALA B CB    1 ? 
ATOM   8445  N  N     . CYS B 1 529 ? -33.138 3.582   -94.636  1    36.004  ? 529  CYS B N     1 ? 
ATOM   8446  C  CA    . CYS B 1 529 ? -34.57  3.303   -94.606  1    39.962  ? 529  CYS B CA    1 ? 
ATOM   8447  C  C     . CYS B 1 529 ? -35.174 3.413   -93.197  1    48.249  ? 529  CYS B C     1 ? 
ATOM   8448  O  O     . CYS B 1 529 ? -36.403 3.464   -93.052  1    45.203  ? 529  CYS B O     1 ? 
ATOM   8449  C  CB    . CYS B 1 529 ? -34.858 1.918   -95.173  1    45.268  ? 529  CYS B CB    1 ? 
ATOM   8450  S  SG    . CYS B 1 529 ? -34.059 0.586   -94.223  1    55.007  ? 529  CYS B SG    1 ? 
ATOM   8451  N  N     . TYR B 1 530 ? -34.317 3.415   -92.157  1    45.233  ? 530  TYR B N     1 ? 
ATOM   8452  C  CA    . TYR B 1 530 ? -34.77  3.44    -90.765  1    43.587  ? 530  TYR B CA    1 ? 
ATOM   8453  C  C     . TYR B 1 530 ? -34.587 4.816   -90.118  1    45.185  ? 530  TYR B C     1 ? 
ATOM   8454  O  O     . TYR B 1 530 ? -35.261 5.115   -89.125  1    44.044  ? 530  TYR B O     1 ? 
ATOM   8455  C  CB    . TYR B 1 530 ? -33.949 2.449   -89.93   1    41.113  ? 530  TYR B CB    1 ? 
ATOM   8456  C  CG    . TYR B 1 530 ? -34.202 0.996   -90.275  1    36.333  ? 530  TYR B CG    1 ? 
ATOM   8457  C  CD1   . TYR B 1 530 ? -35.504 0.497   -90.337  1    35.77   ? 530  TYR B CD1   1 ? 
ATOM   8458  C  CD2   . TYR B 1 530 ? -33.141 0.139   -90.538  1    37.26   ? 530  TYR B CD2   1 ? 
ATOM   8459  C  CE1   . TYR B 1 530 ? -35.736 -0.834  -90.639  1    38.875  ? 530  TYR B CE1   1 ? 
ATOM   8460  C  CE2   . TYR B 1 530 ? -33.366 -1.193  -90.847  1    33.631  ? 530  TYR B CE2   1 ? 
ATOM   8461  C  CZ    . TYR B 1 530 ? -34.664 -1.669  -90.899  1    36.912  ? 530  TYR B CZ    1 ? 
ATOM   8462  O  OH    . TYR B 1 530 ? -34.908 -2.969  -91.2    1    43.571  ? 530  TYR B OH    1 ? 
ATOM   8463  N  N     . GLN B 1 531 ? -33.66  5.625   -90.663  1    40.176  ? 531  GLN B N     1 ? 
ATOM   8464  C  CA    . GLN B 1 531 ? -33.203 6.861   -90.046  1    41.991  ? 531  GLN B CA    1 ? 
ATOM   8465  C  C     . GLN B 1 531 ? -34.346 7.776   -89.609  1    42.885  ? 531  GLN B C     1 ? 
ATOM   8466  O  O     . GLN B 1 531 ? -34.276 8.378   -88.544  1    46.957  ? 531  GLN B O     1 ? 
ATOM   8467  C  CB    . GLN B 1 531 ? -32.204 7.567   -90.952  1    37.694  ? 531  GLN B CB    1 ? 
ATOM   8468  C  CG    . GLN B 1 531 ? -30.903 6.791   -91.056  1    40.928  ? 531  GLN B CG    1 ? 
ATOM   8469  C  CD    . GLN B 1 531 ? -29.841 7.516   -91.846  1    44.656  ? 531  GLN B CD    1 ? 
ATOM   8470  O  OE1   . GLN B 1 531 ? -29.945 8.706   -92.166  1    51.887  ? 531  GLN B OE1   1 ? 
ATOM   8471  N  NE2   . GLN B 1 531 ? -28.794 6.78    -92.161  1    42.192  ? 531  GLN B NE2   1 ? 
ATOM   8472  N  N     . HIS B 1 532 ? -35.399 7.886   -90.424  1    41.351  ? 532  HIS B N     1 ? 
ATOM   8473  C  CA    . HIS B 1 532 ? -36.487 8.796   -90.096  1    41.061  ? 532  HIS B CA    1 ? 
ATOM   8474  C  C     . HIS B 1 532 ? -37.216 8.405   -88.808  1    38.749  ? 532  HIS B C     1 ? 
ATOM   8475  O  O     . HIS B 1 532 ? -37.884 9.248   -88.225  1    35.349  ? 532  HIS B O     1 ? 
ATOM   8476  C  CB    . HIS B 1 532 ? -37.501 8.912   -91.241  1    40.018  ? 532  HIS B CB    1 ? 
ATOM   8477  C  CG    . HIS B 1 532 ? -38.221 7.639   -91.534  1    37.037  ? 532  HIS B CG    1 ? 
ATOM   8478  N  ND1   . HIS B 1 532 ? -37.694 6.665   -92.351  1    42.372  ? 532  HIS B ND1   1 ? 
ATOM   8479  C  CD2   . HIS B 1 532 ? -39.398 7.175   -91.105  1    37.175  ? 532  HIS B CD2   1 ? 
ATOM   8480  C  CE1   . HIS B 1 532 ? -38.558 5.656   -92.416  1    48.087  ? 532  HIS B CE1   1 ? 
ATOM   8481  N  NE2   . HIS B 1 532 ? -39.603 5.95    -91.667  1    39.577  ? 532  HIS B NE2   1 ? 
ATOM   8482  N  N     . LEU B 1 533 ? -37.154 7.131   -88.399  1    36.952  ? 533  LEU B N     1 ? 
ATOM   8483  C  CA    . LEU B 1 533 ? -37.88  6.691   -87.209  1    40.654  ? 533  LEU B CA    1 ? 
ATOM   8484  C  C     . LEU B 1 533 ? -37.342 7.41    -85.97   1    38.647  ? 533  LEU B C     1 ? 
ATOM   8485  O  O     . LEU B 1 533 ? -38.047 7.561   -84.982  1    36.306  ? 533  LEU B O     1 ? 
ATOM   8486  C  CB    . LEU B 1 533 ? -37.82  5.17    -87.03   1    38.975  ? 533  LEU B CB    1 ? 
ATOM   8487  C  CG    . LEU B 1 533 ? -38.46  4.337   -88.148  1    40.537  ? 533  LEU B CG    1 ? 
ATOM   8488  C  CD1   . LEU B 1 533 ? -38.171 2.833   -88.025  1    35.039  ? 533  LEU B CD1   1 ? 
ATOM   8489  C  CD2   . LEU B 1 533 ? -39.967 4.579   -88.236  1    35.791  ? 533  LEU B CD2   1 ? 
ATOM   8490  N  N     . MET B 1 534 ? -36.082 7.845   -86.047  1    36.934  ? 534  MET B N     1 ? 
ATOM   8491  C  CA    . MET B 1 534 ? -35.387 8.443   -84.922  1    37.838  ? 534  MET B CA    1 ? 
ATOM   8492  C  C     . MET B 1 534 ? -35.469 9.969   -84.967  1    42.419  ? 534  MET B C     1 ? 
ATOM   8493  O  O     . MET B 1 534 ? -35.241 10.587  -83.928  1    39.937  ? 534  MET B O     1 ? 
ATOM   8494  C  CB    . MET B 1 534 ? -33.895 8.103   -84.991  1    37.778  ? 534  MET B CB    1 ? 
ATOM   8495  C  CG    . MET B 1 534 ? -33.609 6.619   -85.181  1    44.613  ? 534  MET B CG    1 ? 
ATOM   8496  S  SD    . MET B 1 534 ? -31.842 6.23    -85.198  1    50.027  ? 534  MET B SD    1 ? 
ATOM   8497  C  CE    . MET B 1 534 ? -31.527 6.168   -83.431  1    39.99   ? 534  MET B CE    1 ? 
ATOM   8498  N  N     . THR B 1 535 ? -35.749 10.57   -86.152  1    42.088  ? 535  THR B N     1 ? 
ATOM   8499  C  CA    . THR B 1 535 ? -35.586 12.012  -86.372  1    37.733  ? 535  THR B CA    1 ? 
ATOM   8500  C  C     . THR B 1 535 ? -36.918 12.727  -86.602  1    39.495  ? 535  THR B C     1 ? 
ATOM   8501  O  O     . THR B 1 535 ? -37.075 13.882  -86.24   1    47.253  ? 535  THR B O     1 ? 
ATOM   8502  C  CB    . THR B 1 535 ? -34.616 12.34   -87.513  1    38.754  ? 535  THR B CB    1 ? 
ATOM   8503  O  OG1   . THR B 1 535 ? -35.021 11.709  -88.735  1    34.019  ? 535  THR B OG1   1 ? 
ATOM   8504  C  CG2   . THR B 1 535 ? -33.175 11.992  -87.189  1    40.813  ? 535  THR B CG2   1 ? 
ATOM   8505  N  N     . ASN B 1 536 ? -37.863 12.067  -87.253  1    36.652  ? 536  ASN B N     1 ? 
ATOM   8506  C  CA    . ASN B 1 536 ? -38.997 12.773  -87.826  1    42.156  ? 536  ASN B CA    1 ? 
ATOM   8507  C  C     . ASN B 1 536 ? -40.086 12.937  -86.774  1    45.726  ? 536  ASN B C     1 ? 
ATOM   8508  O  O     . ASN B 1 536 ? -40.478 11.962  -86.144  1    45.876  ? 536  ASN B O     1 ? 
ATOM   8509  C  CB    . ASN B 1 536 ? -39.549 11.987  -89.005  1    37.764  ? 536  ASN B CB    1 ? 
ATOM   8510  C  CG    . ASN B 1 536 ? -40.545 12.769  -89.833  1    44.146  ? 536  ASN B CG    1 ? 
ATOM   8511  O  OD1   . ASN B 1 536 ? -41.629 13.107  -89.353  1    38.047  ? 536  ASN B OD1   1 ? 
ATOM   8512  N  ND2   . ASN B 1 536 ? -40.21  13.022  -91.093  1    37.574  ? 536  ASN B ND2   1 ? 
ATOM   8513  N  N     . GLU B 1 537 ? -40.611 14.158  -86.644  1    46.342  ? 537  GLU B N     1 ? 
ATOM   8514  C  CA    . GLU B 1 537 ? -41.582 14.505  -85.617  1    52.332  ? 537  GLU B CA    1 ? 
ATOM   8515  C  C     . GLU B 1 537 ? -42.808 13.599  -85.669  1    50.198  ? 537  GLU B C     1 ? 
ATOM   8516  O  O     . GLU B 1 537 ? -43.463 13.402  -84.648  1    48.825  ? 537  GLU B O     1 ? 
ATOM   8517  C  CB    . GLU B 1 537 ? -42.101 15.925  -85.819  1    66.905  ? 537  GLU B CB    1 ? 
ATOM   8518  C  CG    . GLU B 1 537 ? -41.07  16.994  -85.478  1    91.356  ? 537  GLU B CG    1 ? 
ATOM   8519  C  CD    . GLU B 1 537 ? -41.646 18.379  -85.693  1    99.964  ? 537  GLU B CD    1 ? 
ATOM   8520  O  OE1   . GLU B 1 537 ? -41.541 19.195  -84.748  1    107.179 ? 537  GLU B OE1   1 ? 
ATOM   8521  O  OE2   . GLU B 1 537 ? -42.215 18.626  -86.788  1    95.135  ? 537  GLU B OE2   1 ? 
ATOM   8522  N  N     . ASP B 1 538 ? -43.12  13.064  -86.858  1    44.261  ? 538  ASP B N     1 ? 
ATOM   8523  C  CA    . ASP B 1 538 ? -44.295 12.225  -87.037  1    44.265  ? 538  ASP B CA    1 ? 
ATOM   8524  C  C     . ASP B 1 538 ? -43.976 10.723  -86.97   1    39.739  ? 538  ASP B C     1 ? 
ATOM   8525  O  O     . ASP B 1 538 ? -44.889 9.902   -87.101  1    46.113  ? 538  ASP B O     1 ? 
ATOM   8526  C  CB    . ASP B 1 538 ? -45.086 12.626  -88.275  1    55.642  ? 538  ASP B CB    1 ? 
ATOM   8527  C  CG    . ASP B 1 538 ? -45.857 13.941  -88.187  1    65.455  ? 538  ASP B CG    1 ? 
ATOM   8528  O  OD1   . ASP B 1 538 ? -46.78  14.043  -87.346  1    65.284  ? 538  ASP B OD1   1 ? 
ATOM   8529  O  OD2   . ASP B 1 538 ? -45.549 14.848  -88.983  1    68.015  ? 538  ASP B OD2   1 ? 
ATOM   8530  N  N     . SER B 1 539 ? -42.7   10.355  -86.77   1    37.079  ? 539  SER B N     1 ? 
ATOM   8531  C  CA    . SER B 1 539 ? -42.334 8.962   -86.51   1    42.661  ? 539  SER B CA    1 ? 
ATOM   8532  C  C     . SER B 1 539 ? -43.175 8.369   -85.373  1    35.556  ? 539  SER B C     1 ? 
ATOM   8533  O  O     . SER B 1 539 ? -43.316 9.01    -84.335  1    38.232  ? 539  SER B O     1 ? 
ATOM   8534  C  CB    . SER B 1 539 ? -40.861 8.813   -86.18   1    42.94   ? 539  SER B CB    1 ? 
ATOM   8535  O  OG    . SER B 1 539 ? -40.614 7.502   -85.676  1    36.469  ? 539  SER B OG    1 ? 
ATOM   8536  N  N     . PRO B 1 540 ? -43.749 7.152   -85.537  1    37.24   ? 540  PRO B N     1 ? 
ATOM   8537  C  CA    . PRO B 1 540 ? -44.583 6.516   -84.506  1    42.228  ? 540  PRO B CA    1 ? 
ATOM   8538  C  C     . PRO B 1 540 ? -43.898 6.192   -83.179  1    44.021  ? 540  PRO B C     1 ? 
ATOM   8539  O  O     . PRO B 1 540 ? -44.576 5.911   -82.194  1    43.384  ? 540  PRO B O     1 ? 
ATOM   8540  C  CB    . PRO B 1 540 ? -45.133 5.252   -85.184  1    37.022  ? 540  PRO B CB    1 ? 
ATOM   8541  C  CG    . PRO B 1 540 ? -44.127 4.97    -86.257  1    37.107  ? 540  PRO B CG    1 ? 
ATOM   8542  C  CD    . PRO B 1 540 ? -43.695 6.344   -86.764  1    35.536  ? 540  PRO B CD    1 ? 
ATOM   8543  N  N     . ILE B 1 541 ? -42.565 6.304   -83.161  1    41.993  ? 541  ILE B N     1 ? 
ATOM   8544  C  CA    . ILE B 1 541 ? -41.756 5.975   -81.997  1    41.254  ? 541  ILE B CA    1 ? 
ATOM   8545  C  C     . ILE B 1 541 ? -40.787 7.117   -81.724  1    43.685  ? 541  ILE B C     1 ? 
ATOM   8546  O  O     . ILE B 1 541 ? -39.723 6.891   -81.137  1    41.424  ? 541  ILE B O     1 ? 
ATOM   8547  C  CB    . ILE B 1 541 ? -41.03  4.628   -82.198  1    39.808  ? 541  ILE B CB    1 ? 
ATOM   8548  C  CG1   . ILE B 1 541 ? -40.055 4.665   -83.383  1    36.819  ? 541  ILE B CG1   1 ? 
ATOM   8549  C  CG2   . ILE B 1 541 ? -42.061 3.502   -82.337  1    38.799  ? 541  ILE B CG2   1 ? 
ATOM   8550  C  CD1   . ILE B 1 541 ? -39.335 3.357   -83.656  1    36.72   ? 541  ILE B CD1   1 ? 
ATOM   8551  N  N     . ILE B 1 542 ? -41.171 8.335   -82.145  1    34.66   ? 542  ILE B N     1 ? 
ATOM   8552  C  CA    . ILE B 1 542 ? -40.332 9.508   -81.94   1    39.844  ? 542  ILE B CA    1 ? 
ATOM   8553  C  C     . ILE B 1 542 ? -40.023 9.702   -80.451  1    38.153  ? 542  ILE B C     1 ? 
ATOM   8554  O  O     . ILE B 1 542 ? -38.936 10.168  -80.098  1    38.478  ? 542  ILE B O     1 ? 
ATOM   8555  C  CB    . ILE B 1 542 ? -40.922 10.787  -82.583  1    38.003  ? 542  ILE B CB    1 ? 
ATOM   8556  C  CG1   . ILE B 1 542 ? -39.923 11.953  -82.556  1    38.767  ? 542  ILE B CG1   1 ? 
ATOM   8557  C  CG2   . ILE B 1 542 ? -42.245 11.18   -81.916  1    37.176  ? 542  ILE B CG2   1 ? 
ATOM   8558  C  CD1   . ILE B 1 542 ? -38.595 11.677  -83.251  1    43.54   ? 542  ILE B CD1   1 ? 
ATOM   8559  N  N     . GLU B 1 543 ? -40.958 9.311   -79.579  1    40.949  ? 543  GLU B N     1 ? 
ATOM   8560  C  CA    . GLU B 1 543 ? -40.766 9.55    -78.154  1    43.799  ? 543  GLU B CA    1 ? 
ATOM   8561  C  C     . GLU B 1 543 ? -39.609 8.749   -77.541  1    44.334  ? 543  GLU B C     1 ? 
ATOM   8562  O  O     . GLU B 1 543 ? -39.205 9.062   -76.421  1    43.954  ? 543  GLU B O     1 ? 
ATOM   8563  C  CB    . GLU B 1 543 ? -42.026 9.456   -77.298  1    51.329  ? 543  GLU B CB    1 ? 
ATOM   8564  C  CG    . GLU B 1 543 ? -42.592 8.042   -77.285  1    53.321  ? 543  GLU B CG    1 ? 
ATOM   8565  C  CD    . GLU B 1 543 ? -43.764 7.967   -78.224  1    63.149  ? 543  GLU B CD    1 ? 
ATOM   8566  O  OE1   . GLU B 1 543 ? -43.754 8.383   -79.445  1    61.972  ? 543  GLU B OE1   1 ? 
ATOM   8567  O  OE2   . GLU B 1 543 ? -44.721 7.451   -77.612  1    57.735  ? 543  GLU B OE2   1 ? 
ATOM   8568  N  N     . TYR B 1 544 ? -39.063 7.751   -78.25   1    38.615  ? 544  TYR B N     1 ? 
ATOM   8569  C  CA    . TYR B 1 544 ? -37.985 6.931   -77.712  1    38.105  ? 544  TYR B CA    1 ? 
ATOM   8570  C  C     . TYR B 1 544 ? -36.628 7.562   -78.011  1    37.912  ? 544  TYR B C     1 ? 
ATOM   8571  O  O     . TYR B 1 544 ? -35.589 7.067   -77.558  1    39.653  ? 544  TYR B O     1 ? 
ATOM   8572  C  CB    . TYR B 1 544 ? -37.998 5.531   -78.332  1    40.78   ? 544  TYR B CB    1 ? 
ATOM   8573  C  CG    . TYR B 1 544 ? -39.243 4.692   -78.071  1    41.126  ? 544  TYR B CG    1 ? 
ATOM   8574  C  CD1   . TYR B 1 544 ? -40.032 4.909   -76.951  1    44.053  ? 544  TYR B CD1   1 ? 
ATOM   8575  C  CD2   . TYR B 1 544 ? -39.62  3.675   -78.943  1    44.251  ? 544  TYR B CD2   1 ? 
ATOM   8576  C  CE1   . TYR B 1 544 ? -41.163 4.149   -76.697  1    41.568  ? 544  TYR B CE1   1 ? 
ATOM   8577  C  CE2   . TYR B 1 544 ? -40.75  2.907   -78.702  1    48.258  ? 544  TYR B CE2   1 ? 
ATOM   8578  C  CZ    . TYR B 1 544 ? -41.523 3.148   -77.576  1    50.725  ? 544  TYR B CZ    1 ? 
ATOM   8579  O  OH    . TYR B 1 544 ? -42.645 2.419   -77.3    1    57.92   ? 544  TYR B OH    1 ? 
ATOM   8580  N  N     . TYR B 1 545 ? -36.628 8.674   -78.754  1    35.911  ? 545  TYR B N     1 ? 
ATOM   8581  C  CA    . TYR B 1 545 ? -35.369 9.267   -79.182  1    38.318  ? 545  TYR B CA    1 ? 
ATOM   8582  C  C     . TYR B 1 545 ? -35.262 10.727  -78.731  1    43.376  ? 545  TYR B C     1 ? 
ATOM   8583  O  O     . TYR B 1 545 ? -34.817 11.558  -79.521  1    38.558  ? 545  TYR B O     1 ? 
ATOM   8584  C  CB    . TYR B 1 545 ? -35.201 9.075   -80.699  1    40.968  ? 545  TYR B CB    1 ? 
ATOM   8585  C  CG    . TYR B 1 545 ? -35.331 7.61    -81.095  1    38.309  ? 545  TYR B CG    1 ? 
ATOM   8586  C  CD1   . TYR B 1 545 ? -34.256 6.739   -80.946  1    36.519  ? 545  TYR B CD1   1 ? 
ATOM   8587  C  CD2   . TYR B 1 545 ? -36.551 7.091   -81.523  1    38.913  ? 545  TYR B CD2   1 ? 
ATOM   8588  C  CE1   . TYR B 1 545 ? -34.372 5.393   -81.259  1    37.932  ? 545  TYR B CE1   1 ? 
ATOM   8589  C  CE2   . TYR B 1 545 ? -36.684 5.744   -81.83   1    37.853  ? 545  TYR B CE2   1 ? 
ATOM   8590  C  CZ    . TYR B 1 545 ? -35.587 4.901   -81.695  1    39.082  ? 545  TYR B CZ    1 ? 
ATOM   8591  O  OH    . TYR B 1 545 ? -35.701 3.576   -81.972  1    38.199  ? 545  TYR B OH    1 ? 
ATOM   8592  N  N     . PRO B 1 546 ? -35.564 11.091  -77.455  1    42.739  ? 546  PRO B N     1 ? 
ATOM   8593  C  CA    . PRO B 1 546 ? -35.547 12.502  -77.048  1    45.128  ? 546  PRO B CA    1 ? 
ATOM   8594  C  C     . PRO B 1 546 ? -34.142 13.067  -77.208  1    43.511  ? 546  PRO B C     1 ? 
ATOM   8595  O  O     . PRO B 1 546 ? -33.17  12.393  -76.869  1    42.14   ? 546  PRO B O     1 ? 
ATOM   8596  C  CB    . PRO B 1 546 ? -36.014 12.487  -75.57   1    50.612  ? 546  PRO B CB    1 ? 
ATOM   8597  C  CG    . PRO B 1 546 ? -35.701 11.073  -75.09   1    47.18   ? 546  PRO B CG    1 ? 
ATOM   8598  C  CD    . PRO B 1 546 ? -35.891 10.186  -76.331  1    41.59   ? 546  PRO B CD    1 ? 
ATOM   8599  N  N     . PRO B 1 547 ? -33.974 14.272  -77.806  1    49.191  ? 547  PRO B N     1 ? 
ATOM   8600  C  CA    . PRO B 1 547 ? -32.66  14.925  -77.856  1    56.404  ? 547  PRO B CA    1 ? 
ATOM   8601  C  C     . PRO B 1 547 ? -32.09  15.352  -76.498  1    54.479  ? 547  PRO B C     1 ? 
ATOM   8602  O  O     . PRO B 1 547 ? -30.876 15.358  -76.307  1    57.466  ? 547  PRO B O     1 ? 
ATOM   8603  C  CB    . PRO B 1 547 ? -32.834 16.11   -78.858  1    58.139  ? 547  PRO B CB    1 ? 
ATOM   8604  C  CG    . PRO B 1 547 ? -34.156 15.814  -79.553  1    53.085  ? 547  PRO B CG    1 ? 
ATOM   8605  C  CD    . PRO B 1 547 ? -35     15.025  -78.546  1    56.098  ? 547  PRO B CD    1 ? 
ATOM   8606  N  N     . ASP B 1 548 ? -32.962 15.69   -75.541  1    54.812  ? 548  ASP B N     1 ? 
ATOM   8607  C  CA    . ASP B 1 548 ? -32.491 16.065  -74.216  1    58.934  ? 548  ASP B CA    1 ? 
ATOM   8608  C  C     . ASP B 1 548 ? -33.223 15.21   -73.191  1    52.847  ? 548  ASP B C     1 ? 
ATOM   8609  O  O     . ASP B 1 548 ? -34.382 14.846  -73.393  1    48.342  ? 548  ASP B O     1 ? 
ATOM   8610  C  CB    . ASP B 1 548 ? -32.713 17.542  -73.914  1    68.356  ? 548  ASP B CB    1 ? 
ATOM   8611  C  CG    . ASP B 1 548 ? -32.612 18.505  -75.092  1    79.346  ? 548  ASP B CG    1 ? 
ATOM   8612  O  OD1   . ASP B 1 548 ? -31.535 18.537  -75.747  1    69.439  ? 548  ASP B OD1   1 ? 
ATOM   8613  O  OD2   . ASP B 1 548 ? -33.617 19.223  -75.348  1    80.394  ? 548  ASP B OD2   1 ? 
ATOM   8614  N  N     . PHE B 1 549 ? -32.529 14.907  -72.093  1    44.564  ? 549  PHE B N     1 ? 
ATOM   8615  C  CA    . PHE B 1 549 ? -33.05  14.006  -71.079  1    45.452  ? 549  PHE B CA    1 ? 
ATOM   8616  C  C     . PHE B 1 549 ? -32.24  14.271  -69.82   1    44.918  ? 549  PHE B C     1 ? 
ATOM   8617  O  O     . PHE B 1 549 ? -31.113 14.737  -69.918  1    40.757  ? 549  PHE B O     1 ? 
ATOM   8618  C  CB    . PHE B 1 549 ? -32.865 12.539  -71.509  1    41.812  ? 549  PHE B CB    1 ? 
ATOM   8619  C  CG    . PHE B 1 549 ? -31.445 12.247  -71.973  1    39.289  ? 549  PHE B CG    1 ? 
ATOM   8620  C  CD1   . PHE B 1 549 ? -30.428 11.977  -71.061  1    45.908  ? 549  PHE B CD1   1 ? 
ATOM   8621  C  CD2   . PHE B 1 549 ? -31.119 12.269  -73.325  1    40.715  ? 549  PHE B CD2   1 ? 
ATOM   8622  C  CE1   . PHE B 1 549 ? -29.118 11.771  -71.492  1    45.278  ? 549  PHE B CE1   1 ? 
ATOM   8623  C  CE2   . PHE B 1 549 ? -29.811 12.06   -73.751  1    41.447  ? 549  PHE B CE2   1 ? 
ATOM   8624  C  CZ    . PHE B 1 549 ? -28.813 11.816  -72.836  1    43.458  ? 549  PHE B CZ    1 ? 
ATOM   8625  N  N     . LYS B 1 550 ? -32.816 13.947  -68.658  1    57.825  ? 550  LYS B N     1 ? 
ATOM   8626  C  CA    . LYS B 1 550 ? -32.117 14.109  -67.391  1    67.697  ? 550  LYS B CA    1 ? 
ATOM   8627  C  C     . LYS B 1 550 ? -31.224 12.903  -67.11   1    58.985  ? 550  LYS B C     1 ? 
ATOM   8628  O  O     . LYS B 1 550 ? -31.533 11.783  -67.511  1    58.806  ? 550  LYS B O     1 ? 
ATOM   8629  C  CB    . LYS B 1 550 ? -33.105 14.42   -66.256  1    75.823  ? 550  LYS B CB    1 ? 
ATOM   8630  C  CG    . LYS B 1 550 ? -33.206 15.89   -65.862  1    89.795  ? 550  LYS B CG    1 ? 
ATOM   8631  C  CD    . LYS B 1 550 ? -33.677 16.85   -66.949  1    98.98   ? 550  LYS B CD    1 ? 
ATOM   8632  C  CE    . LYS B 1 550 ? -33.386 18.283  -66.619  1    99.366  ? 550  LYS B CE    1 ? 
ATOM   8633  N  NZ    . LYS B 1 550 ? -33.981 19.209  -67.589  1    95.384  ? 550  LYS B NZ    1 ? 
ATOM   8634  N  N     . THR B 1 551 ? -30.118 13.173  -66.406  1    60.051  ? 551  THR B N     1 ? 
ATOM   8635  C  CA    . THR B 1 551 ? -29.174 12.183  -65.909  1    67.079  ? 551  THR B CA    1 ? 
ATOM   8636  C  C     . THR B 1 551 ? -29.001 12.345  -64.393  1    76.613  ? 551  THR B C     1 ? 
ATOM   8637  O  O     . THR B 1 551 ? -29.023 13.462  -63.877  1    79.278  ? 551  THR B O     1 ? 
ATOM   8638  C  CB    . THR B 1 551 ? -27.851 12.359  -66.656  1    64.072  ? 551  THR B CB    1 ? 
ATOM   8639  O  OG1   . THR B 1 551 ? -28.209 12.126  -68.011  1    64.79   ? 551  THR B OG1   1 ? 
ATOM   8640  C  CG2   . THR B 1 551 ? -26.81  11.317  -66.294  1    66.023  ? 551  THR B CG2   1 ? 
ATOM   8641  N  N     . ASP B 1 552 ? -28.827 11.212  -63.689  1    83.172  ? 552  ASP B N     1 ? 
ATOM   8642  C  CA    . ASP B 1 552 ? -28.498 11.172  -62.268  1    74.404  ? 552  ASP B CA    1 ? 
ATOM   8643  C  C     . ASP B 1 552 ? -26.989 10.918  -62.081  1    67.29   ? 552  ASP B C     1 ? 
ATOM   8644  O  O     . ASP B 1 552 ? -26.491 9.905   -62.644  1    60.542  ? 552  ASP B O     1 ? 
ATOM   8645  C  CB    . ASP B 1 552 ? -29.384 10.184  -61.52   1    62.94   ? 552  ASP B CB    1 ? 
ATOM   8646  C  CG    . ASP B 1 552 ? -30.87  10.516  -61.468  1    61.009  ? 552  ASP B CG    1 ? 
ATOM   8647  O  OD1   . ASP B 1 552 ? -31.233 11.654  -61.802  1    63.181  ? 552  ASP B OD1   1 ? 
ATOM   8648  O  OD2   . ASP B 1 552 ? -31.668 9.631   -61.089  1    67.181  ? 552  ASP B OD2   1 ? 
ATOM   8649  N  N     . ALA B 1 562 ? -23.952 5.653   -64.085  1    69.392  ? 562  ALA B N     1 ? 
ATOM   8650  C  CA    . ALA B 1 562 ? -24.875 6.754   -64.466  1    73.95   ? 562  ALA B CA    1 ? 
ATOM   8651  C  C     . ALA B 1 562 ? -26.259 6.2     -64.813  1    73.818  ? 562  ALA B C     1 ? 
ATOM   8652  O  O     . ALA B 1 562 ? -26.368 5.105   -65.363  1    77.323  ? 562  ALA B O     1 ? 
ATOM   8653  C  CB    . ALA B 1 562 ? -24.285 7.53    -65.624  1    70.639  ? 562  ALA B CB    1 ? 
ATOM   8654  N  N     . VAL B 1 563 ? -27.311 6.968   -64.491  1    64.427  ? 563  VAL B N     1 ? 
ATOM   8655  C  CA    . VAL B 1 563 ? -28.679 6.569   -64.787  1    67.124  ? 563  VAL B CA    1 ? 
ATOM   8656  C  C     . VAL B 1 563 ? -29.29  7.571   -65.767  1    66.329  ? 563  VAL B C     1 ? 
ATOM   8657  O  O     . VAL B 1 563 ? -29.478 8.737   -65.429  1    64.031  ? 563  VAL B O     1 ? 
ATOM   8658  C  CB    . VAL B 1 563 ? -29.549 6.405   -63.52   1    70.96   ? 563  VAL B CB    1 ? 
ATOM   8659  C  CG1   . VAL B 1 563 ? -31.016 6.133   -63.841  1    62.195  ? 563  VAL B CG1   1 ? 
ATOM   8660  C  CG2   . VAL B 1 563 ? -29.004 5.314   -62.604  1    78.2    ? 563  VAL B CG2   1 ? 
ATOM   8661  N  N     . VAL B 1 564 ? -29.623 7.091   -66.973  1    64.135  ? 564  VAL B N     1 ? 
ATOM   8662  C  CA    . VAL B 1 564 ? -30.125 7.93    -68.053  1    53.252  ? 564  VAL B CA    1 ? 
ATOM   8663  C  C     . VAL B 1 564 ? -31.646 7.815   -68.089  1    46.104  ? 564  VAL B C     1 ? 
ATOM   8664  O  O     . VAL B 1 564 ? -32.182 6.717   -68.222  1    47.237  ? 564  VAL B O     1 ? 
ATOM   8665  C  CB    . VAL B 1 564 ? -29.422 7.475   -69.351  1    52.522  ? 564  VAL B CB    1 ? 
ATOM   8666  C  CG1   . VAL B 1 564 ? -29.887 8.237   -70.585  1    44.555  ? 564  VAL B CG1   1 ? 
ATOM   8667  C  CG2   . VAL B 1 564 ? -27.909 7.596   -69.213  1    46.558  ? 564  VAL B CG2   1 ? 
ATOM   8668  N  N     . LEU B 1 565 ? -32.342 8.951   -67.925  1    45.768  ? 565  LEU B N     1 ? 
ATOM   8669  C  CA    . LEU B 1 565 ? -33.79  8.914   -67.742  1    48.903  ? 565  LEU B CA    1 ? 
ATOM   8670  C  C     . LEU B 1 565 ? -34.5   9.106   -69.081  1    52.587  ? 565  LEU B C     1 ? 
ATOM   8671  O  O     . LEU B 1 565 ? -34.878 10.224  -69.439  1    51.694  ? 565  LEU B O     1 ? 
ATOM   8672  C  CB    . LEU B 1 565 ? -34.272 9.898   -66.674  1    50.387  ? 565  LEU B CB    1 ? 
ATOM   8673  C  CG    . LEU B 1 565 ? -33.696 9.682   -65.267  1    52.483  ? 565  LEU B CG    1 ? 
ATOM   8674  C  CD1   . LEU B 1 565 ? -34.165 10.756  -64.284  1    54.753  ? 565  LEU B CD1   1 ? 
ATOM   8675  C  CD2   . LEU B 1 565 ? -33.972 8.294   -64.712  1    52.012  ? 565  LEU B CD2   1 ? 
ATOM   8676  N  N     . ILE B 1 566 ? -34.642 7.984   -69.808  1    50.493  ? 566  ILE B N     1 ? 
ATOM   8677  C  CA    . ILE B 1 566 ? -35.215 7.927   -71.144  1    48.437  ? 566  ILE B CA    1 ? 
ATOM   8678  C  C     . ILE B 1 566 ? -36.234 6.796   -71.148  1    52.69   ? 566  ILE B C     1 ? 
ATOM   8679  O  O     . ILE B 1 566 ? -36.163 5.907   -70.303  1    52.283  ? 566  ILE B O     1 ? 
ATOM   8680  C  CB    . ILE B 1 566 ? -34.14  7.729   -72.229  1    43.343  ? 566  ILE B CB    1 ? 
ATOM   8681  C  CG1   . ILE B 1 566 ? -33.313 6.438   -72.014  1    44.473  ? 566  ILE B CG1   1 ? 
ATOM   8682  C  CG2   . ILE B 1 566 ? -33.245 8.965   -72.367  1    32.74   ? 566  ILE B CG2   1 ? 
ATOM   8683  C  CD1   . ILE B 1 566 ? -32.249 6.209   -73.079  1    40.683  ? 566  ILE B CD1   1 ? 
ATOM   8684  N  N     . PRO B 1 567 ? -37.224 6.805   -72.069  1    48.739  ? 567  PRO B N     1 ? 
ATOM   8685  C  CA    . PRO B 1 567 ? -38.276 5.788   -72.055  1    46.254  ? 567  PRO B CA    1 ? 
ATOM   8686  C  C     . PRO B 1 567 ? -37.795 4.371   -72.366  1    41.329  ? 567  PRO B C     1 ? 
ATOM   8687  O  O     . PRO B 1 567 ? -36.708 4.168   -72.931  1    40.5    ? 567  PRO B O     1 ? 
ATOM   8688  C  CB    . PRO B 1 567 ? -39.33  6.285   -73.053  1    47.426  ? 567  PRO B CB    1 ? 
ATOM   8689  C  CG    . PRO B 1 567 ? -38.882 7.687   -73.41   1    46.092  ? 567  PRO B CG    1 ? 
ATOM   8690  C  CD    . PRO B 1 567 ? -37.4   7.8     -73.139  1    46.348  ? 567  PRO B CD    1 ? 
ATOM   8691  N  N     . PHE B 1 568 ? -38.601 3.411   -71.904  1    38.157  ? 568  PHE B N     1 ? 
ATOM   8692  C  CA    . PHE B 1 568 ? -38.453 2.004   -72.211  1    45.217  ? 568  PHE B CA    1 ? 
ATOM   8693  C  C     . PHE B 1 568 ? -39.231 1.717   -73.494  1    49.582  ? 568  PHE B C     1 ? 
ATOM   8694  O  O     . PHE B 1 568 ? -40.434 1.993   -73.585  1    45.657  ? 568  PHE B O     1 ? 
ATOM   8695  C  CB    . PHE B 1 568 ? -38.981 1.119   -71.075  1    45.736  ? 568  PHE B CB    1 ? 
ATOM   8696  C  CG    . PHE B 1 568 ? -38.138 1.198   -69.813  1    48.595  ? 568  PHE B CG    1 ? 
ATOM   8697  C  CD1   . PHE B 1 568 ? -36.88  0.596   -69.759  1    43.298  ? 568  PHE B CD1   1 ? 
ATOM   8698  C  CD2   . PHE B 1 568 ? -38.603 1.881   -68.689  1    45.651  ? 568  PHE B CD2   1 ? 
ATOM   8699  C  CE1   . PHE B 1 568 ? -36.099 0.682   -68.615  1    48.09   ? 568  PHE B CE1   1 ? 
ATOM   8700  C  CE2   . PHE B 1 568 ? -37.828 1.937   -67.535  1    51.405  ? 568  PHE B CE2   1 ? 
ATOM   8701  C  CZ    . PHE B 1 568 ? -36.574 1.349   -67.501  1    46.286  ? 568  PHE B CZ    1 ? 
ATOM   8702  N  N     . ILE B 1 569 ? -38.503 1.165   -74.467  1    45.527  ? 569  ILE B N     1 ? 
ATOM   8703  C  CA    . ILE B 1 569 ? -39.011 0.836   -75.787  1    46.423  ? 569  ILE B CA    1 ? 
ATOM   8704  C  C     . ILE B 1 569 ? -40.026 -0.301  -75.662  1    44.591  ? 569  ILE B C     1 ? 
ATOM   8705  O  O     . ILE B 1 569 ? -39.776 -1.285  -74.973  1    43.895  ? 569  ILE B O     1 ? 
ATOM   8706  C  CB    . ILE B 1 569 ? -37.809 0.46    -76.671  1    45.187  ? 569  ILE B CB    1 ? 
ATOM   8707  C  CG1   . ILE B 1 569 ? -36.952 1.686   -76.937  1    44.145  ? 569  ILE B CG1   1 ? 
ATOM   8708  C  CG2   . ILE B 1 569 ? -38.26  -0.212  -77.964  1    44.84   ? 569  ILE B CG2   1 ? 
ATOM   8709  C  CD1   . ILE B 1 569 ? -35.729 1.406   -77.786  1    50.157  ? 569  ILE B CD1   1 ? 
ATOM   8710  N  N     . ASP B 1 570 ? -41.188 -0.151  -76.304  1    44.858  ? 570  ASP B N     1 ? 
ATOM   8711  C  CA    . ASP B 1 570 ? -42.145 -1.247  -76.375  1    47.179  ? 570  ASP B CA    1 ? 
ATOM   8712  C  C     . ASP B 1 570 ? -41.763 -2.104  -77.584  1    47.696  ? 570  ASP B C     1 ? 
ATOM   8713  O  O     . ASP B 1 570 ? -41.634 -1.574  -78.687  1    46.321  ? 570  ASP B O     1 ? 
ATOM   8714  C  CB    . ASP B 1 570 ? -43.568 -0.711  -76.391  1    51.3    ? 570  ASP B CB    1 ? 
ATOM   8715  C  CG    . ASP B 1 570 ? -44.674 -1.755  -76.404  1    55.392  ? 570  ASP B CG    1 ? 
ATOM   8716  O  OD1   . ASP B 1 570 ? -44.704 -2.566  -77.34   1    56.606  ? 570  ASP B OD1   1 ? 
ATOM   8717  O  OD2   . ASP B 1 570 ? -45.513 -1.73   -75.484  1    74.351  ? 570  ASP B OD2   1 ? 
ATOM   8718  N  N     . GLU B 1 571 ? -41.513 -3.404  -77.362  1    44.135  ? 571  GLU B N     1 ? 
ATOM   8719  C  CA    . GLU B 1 571 ? -40.983 -4.287  -78.397  1    48.727  ? 571  GLU B CA    1 ? 
ATOM   8720  C  C     . GLU B 1 571 ? -41.904 -4.297  -79.624  1    47.011  ? 571  GLU B C     1 ? 
ATOM   8721  O  O     . GLU B 1 571 ? -41.421 -4.163  -80.749  1    41.389  ? 571  GLU B O     1 ? 
ATOM   8722  C  CB    . GLU B 1 571 ? -40.732 -5.697  -77.856  1    55.184  ? 571  GLU B CB    1 ? 
ATOM   8723  C  CG    . GLU B 1 571 ? -40.158 -6.658  -78.894  1    64.642  ? 571  GLU B CG    1 ? 
ATOM   8724  C  CD    . GLU B 1 571 ? -40.014 -8.127  -78.502  1    63.56   ? 571  GLU B CD    1 ? 
ATOM   8725  O  OE1   . GLU B 1 571 ? -39.222 -8.401  -77.575  1    53.649  ? 571  GLU B OE1   1 ? 
ATOM   8726  O  OE2   . GLU B 1 571 ? -40.659 -8.996  -79.145  1    62.103  ? 571  GLU B OE2   1 ? 
ATOM   8727  N  N     . LYS B 1 572 ? -43.221 -4.432  -79.394  1    39.642  ? 572  LYS B N     1 ? 
ATOM   8728  C  CA    . LYS B 1 572 ? -44.197 -4.511  -80.472  1    49.055  ? 572  LYS B CA    1 ? 
ATOM   8729  C  C     . LYS B 1 572 ? -44.18  -3.23   -81.316  1    50.133  ? 572  LYS B C     1 ? 
ATOM   8730  O  O     . LYS B 1 572 ? -44.23  -3.292  -82.541  1    50.212  ? 572  LYS B O     1 ? 
ATOM   8731  C  CB    . LYS B 1 572 ? -45.602 -4.85   -79.959  1    55.948  ? 572  LYS B CB    1 ? 
ATOM   8732  C  CG    . LYS B 1 572 ? -45.716 -6.135  -79.127  1    70.906  ? 572  LYS B CG    1 ? 
ATOM   8733  C  CD    . LYS B 1 572 ? -47.137 -6.662  -78.95   1    78.884  ? 572  LYS B CD    1 ? 
ATOM   8734  C  CE    . LYS B 1 572 ? -47.623 -7.338  -80.199  1    89.104  ? 572  LYS B CE    1 ? 
ATOM   8735  N  NZ    . LYS B 1 572 ? -49.074 -7.537  -80.212  1    86.981  ? 572  LYS B NZ    1 ? 
ATOM   8736  N  N     . ARG B 1 573 ? -44.1   -2.064  -80.663  1    45.074  ? 573  ARG B N     1 ? 
ATOM   8737  C  CA    . ARG B 1 573 ? -44.169 -0.796  -81.365  1    47.519  ? 573  ARG B CA    1 ? 
ATOM   8738  C  C     . ARG B 1 573 ? -42.904 -0.592  -82.198  1    50.885  ? 573  ARG B C     1 ? 
ATOM   8739  O  O     . ARG B 1 573 ? -42.994 -0.114  -83.328  1    47.148  ? 573  ARG B O     1 ? 
ATOM   8740  C  CB    . ARG B 1 573 ? -44.508 0.356   -80.412  1    49.439  ? 573  ARG B CB    1 ? 
ATOM   8741  C  CG    . ARG B 1 573 ? -45.934 0.29    -79.878  1    56.339  ? 573  ARG B CG    1 ? 
ATOM   8742  C  CD    . ARG B 1 573 ? -46.139 1.398   -78.86   1    63.157  ? 573  ARG B CD    1 ? 
ATOM   8743  N  NE    . ARG B 1 573 ? -45.516 2.646   -79.326  1    67.043  ? 573  ARG B NE    1 ? 
ATOM   8744  C  CZ    . ARG B 1 573 ? -45.539 3.812   -78.694  1    65.201  ? 573  ARG B CZ    1 ? 
ATOM   8745  N  NH1   . ARG B 1 573 ? -46.137 3.919   -77.521  1    61.096  ? 573  ARG B NH1   1 ? 
ATOM   8746  N  NH2   . ARG B 1 573 ? -44.97  4.871   -79.242  1    70.404  ? 573  ARG B NH2   1 ? 
ATOM   8747  N  N     . LEU B 1 574 ? -41.741 -0.988  -81.654  1    41.935  ? 574  LEU B N     1 ? 
ATOM   8748  C  CA    . LEU B 1 574 ? -40.492 -0.859  -82.389  1    42.44   ? 574  LEU B CA    1 ? 
ATOM   8749  C  C     . LEU B 1 574 ? -40.577 -1.678  -83.675  1    48.302  ? 574  LEU B C     1 ? 
ATOM   8750  O  O     . LEU B 1 574 ? -40.22  -1.205  -84.757  1    50.146  ? 574  LEU B O     1 ? 
ATOM   8751  C  CB    . LEU B 1 574 ? -39.265 -1.263  -81.57   1    37.09   ? 574  LEU B CB    1 ? 
ATOM   8752  C  CG    . LEU B 1 574 ? -37.977 -1.516  -82.361  1    42.504  ? 574  LEU B CG    1 ? 
ATOM   8753  C  CD1   . LEU B 1 574 ? -37.624 -0.307  -83.219  1    44.975  ? 574  LEU B CD1   1 ? 
ATOM   8754  C  CD2   . LEU B 1 574 ? -36.774 -1.907  -81.497  1    41.081  ? 574  LEU B CD2   1 ? 
ATOM   8755  N  N     . LEU B 1 575 ? -41.003 -2.931  -83.54   1    47.129  ? 575  LEU B N     1 ? 
ATOM   8756  C  CA    . LEU B 1 575 ? -40.964 -3.847  -84.671  1    52.114  ? 575  LEU B CA    1 ? 
ATOM   8757  C  C     . LEU B 1 575 ? -42.035 -3.46   -85.694  1    52.061  ? 575  LEU B C     1 ? 
ATOM   8758  O  O     . LEU B 1 575 ? -41.757 -3.397  -86.891  1    48.287  ? 575  LEU B O     1 ? 
ATOM   8759  C  CB    . LEU B 1 575 ? -41.047 -5.314  -84.236  1    46.494  ? 575  LEU B CB    1 ? 
ATOM   8760  C  CG    . LEU B 1 575 ? -39.818 -5.857  -83.499  1    44.591  ? 575  LEU B CG    1 ? 
ATOM   8761  C  CD1   . LEU B 1 575 ? -39.926 -7.361  -83.262  1    47.911  ? 575  LEU B CD1   1 ? 
ATOM   8762  C  CD2   . LEU B 1 575 ? -38.501 -5.532  -84.177  1    42.111  ? 575  LEU B CD2   1 ? 
ATOM   8763  N  N     . GLU B 1 576 ? -43.244 -3.17   -85.202  1    47.084  ? 576  GLU B N     1 ? 
ATOM   8764  C  CA    . GLU B 1 576 ? -44.322 -2.703  -86.051  1    58.18   ? 576  GLU B CA    1 ? 
ATOM   8765  C  C     . GLU B 1 576 ? -43.866 -1.517  -86.907  1    57.715  ? 576  GLU B C     1 ? 
ATOM   8766  O  O     . GLU B 1 576 ? -44.208 -1.449  -88.086  1    55.827  ? 576  GLU B O     1 ? 
ATOM   8767  C  CB    . GLU B 1 576 ? -45.539 -2.412  -85.178  1    63.108  ? 576  GLU B CB    1 ? 
ATOM   8768  C  CG    . GLU B 1 576 ? -46.751 -1.943  -85.972  1    79.485  ? 576  GLU B CG    1 ? 
ATOM   8769  C  CD    . GLU B 1 576 ? -47.959 -1.734  -85.078  1    92.192  ? 576  GLU B CD    1 ? 
ATOM   8770  O  OE1   . GLU B 1 576 ? -48.322 -0.552  -84.856  1    91.439  ? 576  GLU B OE1   1 ? 
ATOM   8771  O  OE2   . GLU B 1 576 ? -48.53  -2.753  -84.618  1    88.901  ? 576  GLU B OE2   1 ? 
ATOM   8772  N  N     . ALA B 1 577 ? -43.097 -0.584  -86.32   1    50.775  ? 577  ALA B N     1 ? 
ATOM   8773  C  CA    . ALA B 1 577 ? -42.735 0.644   -87.013  1    57.18   ? 577  ALA B CA    1 ? 
ATOM   8774  C  C     . ALA B 1 577 ? -41.673 0.391   -88.081  1    61.72   ? 577  ALA B C     1 ? 
ATOM   8775  O  O     . ALA B 1 577 ? -41.632 1.11    -89.087  1    63.615  ? 577  ALA B O     1 ? 
ATOM   8776  C  CB    . ALA B 1 577 ? -42.298 1.726   -86.046  1    62.982  ? 577  ALA B CB    1 ? 
ATOM   8777  N  N     . MET B 1 578 ? -40.831 -0.629  -87.85   1    54.093  ? 578  MET B N     1 ? 
ATOM   8778  C  CA    . MET B 1 578 ? -39.778 -0.994  -88.784  1    52.064  ? 578  MET B CA    1 ? 
ATOM   8779  C  C     . MET B 1 578 ? -40.337 -1.742  -89.996  1    54.299  ? 578  MET B C     1 ? 
ATOM   8780  O  O     . MET B 1 578 ? -39.69  -1.718  -91.043  1    56.735  ? 578  MET B O     1 ? 
ATOM   8781  C  CB    . MET B 1 578 ? -38.724 -1.901  -88.145  1    45.514  ? 578  MET B CB    1 ? 
ATOM   8782  C  CG    . MET B 1 578 ? -37.886 -1.237  -87.088  1    47.499  ? 578  MET B CG    1 ? 
ATOM   8783  S  SD    . MET B 1 578 ? -36.758 -2.44   -86.356  1    43.686  ? 578  MET B SD    1 ? 
ATOM   8784  C  CE    . MET B 1 578 ? -35.295 -2.487  -87.403  1    33.838  ? 578  MET B CE    1 ? 
ATOM   8785  N  N     . GLU B 1 579 ? -41.475 -2.453  -89.831  1    57.632  ? 579  GLU B N     1 ? 
ATOM   8786  C  CA    . GLU B 1 579 ? -42.078 -3.273  -90.878  1    62.52   ? 579  GLU B CA    1 ? 
ATOM   8787  C  C     . GLU B 1 579 ? -42.131 -2.487  -92.19   1    66.541  ? 579  GLU B C     1 ? 
ATOM   8788  O  O     . GLU B 1 579 ? -41.688 -2.96   -93.237  1    58.429  ? 579  GLU B O     1 ? 
ATOM   8789  C  CB    . GLU B 1 579 ? -43.527 -3.65   -90.57   1    67.133  ? 579  GLU B CB    1 ? 
ATOM   8790  C  CG    . GLU B 1 579 ? -43.692 -4.941  -89.778  1    83.862  ? 579  GLU B CG    1 ? 
ATOM   8791  C  CD    . GLU B 1 579 ? -45.003 -4.973  -89.001  1    97.69   ? 579  GLU B CD    1 ? 
ATOM   8792  O  OE1   . GLU B 1 579 ? -45.164 -5.853  -88.121  1    102.719 ? 579  GLU B OE1   1 ? 
ATOM   8793  O  OE2   . GLU B 1 579 ? -45.868 -4.104  -89.264  1    97.708  ? 579  GLU B OE2   1 ? 
ATOM   8794  N  N     . THR B 1 580 ? -42.652 -1.261  -92.094  1    69.249  ? 580  THR B N     1 ? 
ATOM   8795  C  CA    . THR B 1 580 ? -42.967 -0.423  -93.235  1    74.087  ? 580  THR B CA    1 ? 
ATOM   8796  C  C     . THR B 1 580 ? -41.691 0.001   -93.973  1    66.813  ? 580  THR B C     1 ? 
ATOM   8797  O  O     . THR B 1 580 ? -41.771 0.514   -95.086  1    64.795  ? 580  THR B O     1 ? 
ATOM   8798  C  CB    . THR B 1 580 ? -43.823 0.743   -92.731  1    83.157  ? 580  THR B CB    1 ? 
ATOM   8799  O  OG1   . THR B 1 580 ? -44.396 1.332   -93.891  1    100.305 ? 580  THR B OG1   1 ? 
ATOM   8800  C  CG2   . THR B 1 580 ? -43.056 1.775   -91.922  1    85.9    ? 580  THR B CG2   1 ? 
ATOM   8801  N  N     . CYS B 1 581 ? -40.512 -0.262  -93.388  1    56.722  ? 581  CYS B N     1 ? 
ATOM   8802  C  CA    . CYS B 1 581 ? -39.268 0.249   -93.941  1    46.355  ? 581  CYS B CA    1 ? 
ATOM   8803  C  C     . CYS B 1 581 ? -38.337 -0.867  -94.384  1    47.568  ? 581  CYS B C     1 ? 
ATOM   8804  O  O     . CYS B 1 581 ? -37.334 -0.576  -95.027  1    55.671  ? 581  CYS B O     1 ? 
ATOM   8805  C  CB    . CYS B 1 581 ? -38.411 0.929   -92.876  1    51.279  ? 581  CYS B CB    1 ? 
ATOM   8806  S  SG    . CYS B 1 581 ? -39.284 2.221   -91.952  1    52.061  ? 581  CYS B SG    1 ? 
ATOM   8807  N  N     . ASN B 1 582 ? -38.627 -2.114  -93.995  1    53.592  ? 582  ASN B N     1 ? 
ATOM   8808  C  CA    . ASN B 1 582 ? -37.61  -3.165  -93.997  1    70.511  ? 582  ASN B CA    1 ? 
ATOM   8809  C  C     . ASN B 1 582 ? -37.218 -3.595  -95.406  1    77.362  ? 582  ASN B C     1 ? 
ATOM   8810  O  O     . ASN B 1 582 ? -36.142 -4.154  -95.613  1    77.779  ? 582  ASN B O     1 ? 
ATOM   8811  C  CB    . ASN B 1 582 ? -38.069 -4.463  -93.343  1    68.697  ? 582  ASN B CB    1 ? 
ATOM   8812  C  CG    . ASN B 1 582 ? -38.153 -4.348  -91.843  1    72.768  ? 582  ASN B CG    1 ? 
ATOM   8813  O  OD1   . ASN B 1 582 ? -37.246 -3.794  -91.21   1    70.12   ? 582  ASN B OD1   1 ? 
ATOM   8814  N  ND2   . ASN B 1 582 ? -39.241 -4.846  -91.271  1    66.829  ? 582  ASN B ND2   1 ? 
ATOM   8815  N  N     . HIS B 1 583 ? -38.121 -3.385  -96.362  1    82.75   ? 583  HIS B N     1 ? 
ATOM   8816  C  CA    . HIS B 1 583 ? -37.868 -3.876  -97.703  1    87.045  ? 583  HIS B CA    1 ? 
ATOM   8817  C  C     . HIS B 1 583 ? -37.286 -2.742  -98.542  1    81.822  ? 583  HIS B C     1 ? 
ATOM   8818  O  O     . HIS B 1 583 ? -37.195 -2.853  -99.76   1    85.849  ? 583  HIS B O     1 ? 
ATOM   8819  C  CB    . HIS B 1 583 ? -39.108 -4.587  -98.255  1    100.743 ? 583  HIS B CB    1 ? 
ATOM   8820  C  CG    . HIS B 1 583 ? -39.712 -5.578  -97.305  1    110.153 ? 583  HIS B CG    1 ? 
ATOM   8821  N  ND1   . HIS B 1 583 ? -39.164 -6.82   -97.049  1    106.792 ? 583  HIS B ND1   1 ? 
ATOM   8822  C  CD2   . HIS B 1 583 ? -40.814 -5.492  -96.537  1    105.663 ? 583  HIS B CD2   1 ? 
ATOM   8823  C  CE1   . HIS B 1 583 ? -39.922 -7.46   -96.167  1    111.122 ? 583  HIS B CE1   1 ? 
ATOM   8824  N  NE2   . HIS B 1 583 ? -40.932 -6.673  -95.846  1    110.961 ? 583  HIS B NE2   1 ? 
ATOM   8825  N  N     . SER B 1 584 ? -36.872 -1.665  -97.866  1    67.162  ? 584  SER B N     1 ? 
ATOM   8826  C  CA    . SER B 1 584 ? -36.122 -0.603  -98.502  1    53.867  ? 584  SER B CA    1 ? 
ATOM   8827  C  C     . SER B 1 584 ? -34.615 -0.789  -98.242  1    59.201  ? 584  SER B C     1 ? 
ATOM   8828  O  O     . SER B 1 584 ? -33.806 0.067   -98.606  1    62.74   ? 584  SER B O     1 ? 
ATOM   8829  C  CB    . SER B 1 584 ? -36.667 0.734   -98.065  1    59.777  ? 584  SER B CB    1 ? 
ATOM   8830  O  OG    . SER B 1 584 ? -36.309 1.791   -98.944  1    71.259  ? 584  SER B OG    1 ? 
ATOM   8831  N  N     . LEU B 1 585 ? -34.237 -1.949  -97.666  1    58.825  ? 585  LEU B N     1 ? 
ATOM   8832  C  CA    . LEU B 1 585 ? -32.867 -2.322  -97.306  1    53.811  ? 585  LEU B CA    1 ? 
ATOM   8833  C  C     . LEU B 1 585 ? -32.064 -2.747  -98.532  1    53.778  ? 585  LEU B C     1 ? 
ATOM   8834  O  O     . LEU B 1 585 ? -32.47  -3.676  -99.235  1    55.524  ? 585  LEU B O     1 ? 
ATOM   8835  C  CB    . LEU B 1 585 ? -32.894 -3.517  -96.351  1    55.777  ? 585  LEU B CB    1 ? 
ATOM   8836  C  CG    . LEU B 1 585 ? -33.133 -3.254  -94.861  1    54.55   ? 585  LEU B CG    1 ? 
ATOM   8837  C  CD1   . LEU B 1 585 ? -33.185 -4.616  -94.168  1    52.728  ? 585  LEU B CD1   1 ? 
ATOM   8838  C  CD2   . LEU B 1 585 ? -32.017 -2.401  -94.302  1    45.927  ? 585  LEU B CD2   1 ? 
ATOM   8839  N  N     . LYS B 1 586 ? -30.871 -2.159  -98.698  1    47.53   ? 586  LYS B N     1 ? 
ATOM   8840  C  CA    . LYS B 1 586 ? -29.952 -2.487  -99.782  1    46.03   ? 586  LYS B CA    1 ? 
ATOM   8841  C  C     . LYS B 1 586 ? -29.406 -3.898  -99.585  1    57.986  ? 586  LYS B C     1 ? 
ATOM   8842  O  O     . LYS B 1 586 ? -29.586 -4.495  -98.521  1    53.551  ? 586  LYS B O     1 ? 
ATOM   8843  C  CB    . LYS B 1 586 ? -28.776 -1.505  -99.829  1    50.197  ? 586  LYS B CB    1 ? 
ATOM   8844  C  CG    . LYS B 1 586 ? -29.161 -0.043  -100.063 1    60.747  ? 586  LYS B CG    1 ? 
ATOM   8845  C  CD    . LYS B 1 586 ? -28.006 0.952   -99.962  1    66.838  ? 586  LYS B CD    1 ? 
ATOM   8846  C  CE    . LYS B 1 586 ? -28.458 2.37    -100.164 1    72.99   ? 586  LYS B CE    1 ? 
ATOM   8847  N  NZ    . LYS B 1 586 ? -29.377 2.827   -99.114  1    63.917  ? 586  LYS B NZ    1 ? 
ATOM   8848  N  N     . LYS B 1 587 ? -28.71  -4.404  -100.612 1    64.632  ? 587  LYS B N     1 ? 
ATOM   8849  C  CA    . LYS B 1 587 ? -28.282 -5.792  -100.674 1    64.96   ? 587  LYS B CA    1 ? 
ATOM   8850  C  C     . LYS B 1 587 ? -27.254 -6.073  -99.577  1    63.833  ? 587  LYS B C     1 ? 
ATOM   8851  O  O     . LYS B 1 587 ? -27.402 -7.047  -98.839  1    60.035  ? 587  LYS B O     1 ? 
ATOM   8852  C  CB    . LYS B 1 587 ? -27.775 -6.118  -102.085 1    78.039  ? 587  LYS B CB    1 ? 
ATOM   8853  C  CG    . LYS B 1 587 ? -27.223 -7.527  -102.314 1    79.24   ? 587  LYS B CG    1 ? 
ATOM   8854  C  CD    . LYS B 1 587 ? -26.729 -7.823  -103.733 1    87.267  ? 587  LYS B CD    1 ? 
ATOM   8855  C  CE    . LYS B 1 587 ? -25.57  -6.979  -104.197 1    88.516  ? 587  LYS B CE    1 ? 
ATOM   8856  N  NZ    . LYS B 1 587 ? -24.954 -7.468  -105.435 1    79.173  ? 587  LYS B NZ    1 ? 
ATOM   8857  N  N     . GLU B 1 588 ? -26.223 -5.222  -99.468  1    55.828  ? 588  GLU B N     1 ? 
ATOM   8858  C  CA    . GLU B 1 588 ? -25.197 -5.401  -98.445  1    56.408  ? 588  GLU B CA    1 ? 
ATOM   8859  C  C     . GLU B 1 588 ? -25.803 -5.292  -97.036  1    59.514  ? 588  GLU B C     1 ? 
ATOM   8860  O  O     . GLU B 1 588 ? -25.277 -5.861  -96.077  1    51.622  ? 588  GLU B O     1 ? 
ATOM   8861  C  CB    . GLU B 1 588 ? -24.017 -4.468  -98.727  1    66.227  ? 588  GLU B CB    1 ? 
ATOM   8862  C  CG    . GLU B 1 588 ? -22.903 -4.522  -97.681  1    75.123  ? 588  GLU B CG    1 ? 
ATOM   8863  C  CD    . GLU B 1 588 ? -23.114 -3.788  -96.355  1    76.418  ? 588  GLU B CD    1 ? 
ATOM   8864  O  OE1   . GLU B 1 588 ? -23.992 -2.89   -96.285  1    67.497  ? 588  GLU B OE1   1 ? 
ATOM   8865  O  OE2   . GLU B 1 588 ? -22.403 -4.133  -95.378  1    62.218  ? 588  GLU B OE2   1 ? 
ATOM   8866  N  N     . GLU B 1 589 ? -26.931 -4.576  -96.923  1    56.291  ? 589  GLU B N     1 ? 
ATOM   8867  C  CA    . GLU B 1 589 ? -27.596 -4.336  -95.652  1    51.579  ? 589  GLU B CA    1 ? 
ATOM   8868  C  C     . GLU B 1 589 ? -28.422 -5.543  -95.221  1    48.931  ? 589  GLU B C     1 ? 
ATOM   8869  O  O     . GLU B 1 589 ? -28.425 -5.864  -94.036  1    47.637  ? 589  GLU B O     1 ? 
ATOM   8870  C  CB    . GLU B 1 589 ? -28.452 -3.069  -95.635  1    51.694  ? 589  GLU B CB    1 ? 
ATOM   8871  C  CG    . GLU B 1 589 ? -27.604 -1.803  -95.703  1    54.084  ? 589  GLU B CG    1 ? 
ATOM   8872  C  CD    . GLU B 1 589 ? -28.391 -0.532  -95.99   1    52.152  ? 589  GLU B CD    1 ? 
ATOM   8873  O  OE1   . GLU B 1 589 ? -29.594 -0.596  -96.352  1    48.768  ? 589  GLU B OE1   1 ? 
ATOM   8874  O  OE2   . GLU B 1 589 ? -27.777 0.532   -95.788  1    49.977  ? 589  GLU B OE2   1 ? 
ATOM   8875  N  N     . ARG B 1 590 ? -29.128 -6.198  -96.156  1    44.161  ? 590  ARG B N     1 ? 
ATOM   8876  C  CA    . ARG B 1 590 ? -29.836 -7.427  -95.818  1    50.525  ? 590  ARG B CA    1 ? 
ATOM   8877  C  C     . ARG B 1 590 ? -28.81  -8.465  -95.359  1    51.533  ? 590  ARG B C     1 ? 
ATOM   8878  O  O     . ARG B 1 590 ? -29.115 -9.293  -94.502  1    52.277  ? 590  ARG B O     1 ? 
ATOM   8879  C  CB    . ARG B 1 590 ? -30.732 -8.038  -96.905  1    56.779  ? 590  ARG B CB    1 ? 
ATOM   8880  C  CG    . ARG B 1 590 ? -31.54  -7.076  -97.766  1    71.326  ? 590  ARG B CG    1 ? 
ATOM   8881  C  CD    . ARG B 1 590 ? -32.337 -7.795  -98.847  1    78.396  ? 590  ARG B CD    1 ? 
ATOM   8882  N  NE    . ARG B 1 590 ? -33.703 -8.079  -98.391  1    88.009  ? 590  ARG B NE    1 ? 
ATOM   8883  C  CZ    . ARG B 1 590 ? -34.743 -7.252  -98.509  1    96.555  ? 590  ARG B CZ    1 ? 
ATOM   8884  N  NH1   . ARG B 1 590 ? -35.903 -7.559  -97.951  1    94.855  ? 590  ARG B NH1   1 ? 
ATOM   8885  N  NH2   . ARG B 1 590 ? -34.616 -6.112  -99.171  1    97.902  ? 590  ARG B NH2   1 ? 
ATOM   8886  N  N     . LYS B 1 591 ? -27.592 -8.382  -95.91   1    46.395  ? 591  LYS B N     1 ? 
ATOM   8887  C  CA    . LYS B 1 591 ? -26.504 -9.287  -95.565  1    56.228  ? 591  LYS B CA    1 ? 
ATOM   8888  C  C     . LYS B 1 591 ? -26.034 -9.066  -94.122  1    53.325  ? 591  LYS B C     1 ? 
ATOM   8889  O  O     . LYS B 1 591 ? -25.685 -10.032 -93.444  1    50.816  ? 591  LYS B O     1 ? 
ATOM   8890  C  CB    . LYS B 1 591 ? -25.348 -9.218  -96.574  1    63.97   ? 591  LYS B CB    1 ? 
ATOM   8891  C  CG    . LYS B 1 591 ? -24.126 -10.074 -96.225  1    75.18   ? 591  LYS B CG    1 ? 
ATOM   8892  C  CD    . LYS B 1 591 ? -22.922 -9.86   -97.132  1    82.882  ? 591  LYS B CD    1 ? 
ATOM   8893  C  CE    . LYS B 1 591 ? -21.745 -10.637 -96.644  1    85.088  ? 591  LYS B CE    1 ? 
ATOM   8894  N  NZ    . LYS B 1 591 ? -20.536 -10.352 -97.423  1    84.211  ? 591  LYS B NZ    1 ? 
ATOM   8895  N  N     . ARG B 1 592 ? -25.997 -7.805  -93.659  1    46.56   ? 592  ARG B N     1 ? 
ATOM   8896  C  CA    . ARG B 1 592 ? -25.589 -7.533  -92.284  1    46.287  ? 592  ARG B CA    1 ? 
ATOM   8897  C  C     . ARG B 1 592 ? -26.691 -7.887  -91.29   1    40.838  ? 592  ARG B C     1 ? 
ATOM   8898  O  O     . ARG B 1 592 ? -26.417 -8.053  -90.11   1    38.75   ? 592  ARG B O     1 ? 
ATOM   8899  C  CB    . ARG B 1 592 ? -25.113 -6.101  -92.008  1    51.277  ? 592  ARG B CB    1 ? 
ATOM   8900  C  CG    . ARG B 1 592 ? -23.66  -5.936  -92.411  1    51.351  ? 592  ARG B CG    1 ? 
ATOM   8901  C  CD    . ARG B 1 592 ? -23.155 -4.635  -91.831  1    51.304  ? 592  ARG B CD    1 ? 
ATOM   8902  N  NE    . ARG B 1 592 ? -23.473 -3.542  -92.747  1    44.923  ? 592  ARG B NE    1 ? 
ATOM   8903  C  CZ    . ARG B 1 592 ? -24.264 -2.506  -92.525  1    45.362  ? 592  ARG B CZ    1 ? 
ATOM   8904  N  NH1   . ARG B 1 592 ? -24.612 -1.752  -93.557  1    41.34   ? 592  ARG B NH1   1 ? 
ATOM   8905  N  NH2   . ARG B 1 592 ? -24.742 -2.26   -91.315  1    38.676  ? 592  ARG B NH2   1 ? 
ATOM   8906  N  N     . ASN B 1 593 ? -27.939 -7.992  -91.75   1    37.762  ? 593  ASN B N     1 ? 
ATOM   8907  C  CA    . ASN B 1 593 ? -29.035 -8.154  -90.816  1    36.386  ? 593  ASN B CA    1 ? 
ATOM   8908  C  C     . ASN B 1 593 ? -29.219 -9.63   -90.462  1    36.538  ? 593  ASN B C     1 ? 
ATOM   8909  O  O     . ASN B 1 593 ? -30.347 -10.106 -90.327  1    37.074  ? 593  ASN B O     1 ? 
ATOM   8910  C  CB    . ASN B 1 593 ? -30.308 -7.474  -91.315  1    34.216  ? 593  ASN B CB    1 ? 
ATOM   8911  C  CG    . ASN B 1 593 ? -31.196 -7.082  -90.155  1    41.579  ? 593  ASN B CG    1 ? 
ATOM   8912  O  OD1   . ASN B 1 593 ? -30.697 -6.717  -89.075  1    35.286  ? 593  ASN B OD1   1 ? 
ATOM   8913  N  ND2   . ASN B 1 593 ? -32.503 -7.147  -90.355  1    36.968  ? 593  ASN B ND2   1 ? 
ATOM   8914  N  N     . GLN B 1 594 ? -28.114 -10.36  -90.284  1    38.655  ? 594  GLN B N     1 ? 
ATOM   8915  C  CA    . GLN B 1 594 ? -28.237 -11.792 -90.024  1    47.724  ? 594  GLN B CA    1 ? 
ATOM   8916  C  C     . GLN B 1 594 ? -27.393 -12.194 -88.804  1    44.889  ? 594  GLN B C     1 ? 
ATOM   8917  O  O     . GLN B 1 594 ? -26.396 -11.538 -88.502  1    46.208  ? 594  GLN B O     1 ? 
ATOM   8918  C  CB    . GLN B 1 594 ? -27.66  -12.47  -91.267  1    54.158  ? 594  GLN B CB    1 ? 
ATOM   8919  C  CG    . GLN B 1 594 ? -26.133 -12.389 -91.258  1    69.292  ? 594  GLN B CG    1 ? 
ATOM   8920  C  CD    . GLN B 1 594 ? -25.433 -12.67  -92.568  1    74.127  ? 594  GLN B CD    1 ? 
ATOM   8921  O  OE1   . GLN B 1 594 ? -26.062 -12.882 -93.613  1    89.974  ? 594  GLN B OE1   1 ? 
ATOM   8922  N  NE2   . GLN B 1 594 ? -24.107 -12.637 -92.513  1    65.912  ? 594  GLN B NE2   1 ? 
ATOM   8923  N  N     . HIS B 1 595 ? -27.773 -13.293 -88.124  1    39.432  ? 595  HIS B N     1 ? 
ATOM   8924  C  CA    . HIS B 1 595 ? -26.93  -13.917 -87.109  1    37.544  ? 595  HIS B CA    1 ? 
ATOM   8925  C  C     . HIS B 1 595 ? -25.981 -14.874 -87.817  1    39.251  ? 595  HIS B C     1 ? 
ATOM   8926  O  O     . HIS B 1 595 ? -26.285 -15.352 -88.908  1    44.435  ? 595  HIS B O     1 ? 
ATOM   8927  C  CB    . HIS B 1 595 ? -27.784 -14.689 -86.093  1    31.632  ? 595  HIS B CB    1 ? 
ATOM   8928  C  CG    . HIS B 1 595 ? -28.705 -13.789 -85.348  1    31.348  ? 595  HIS B CG    1 ? 
ATOM   8929  N  ND1   . HIS B 1 595 ? -28.383 -12.461 -85.125  1    29.422  ? 595  HIS B ND1   1 ? 
ATOM   8930  C  CD2   . HIS B 1 595 ? -29.94  -13.975 -84.846  1    29.805  ? 595  HIS B CD2   1 ? 
ATOM   8931  C  CE1   . HIS B 1 595 ? -29.388 -11.875 -84.473  1    33.985  ? 595  HIS B CE1   1 ? 
ATOM   8932  N  NE2   . HIS B 1 595 ? -30.337 -12.786 -84.291  1    35.596  ? 595  HIS B NE2   1 ? 
ATOM   8933  N  N     . SER B 1 596 ? -24.854 -15.171 -87.187  1    33.247  ? 596  SER B N     1 ? 
ATOM   8934  C  CA    . SER B 1 596 ? -23.833 -15.966 -87.853  1    35.433  ? 596  SER B CA    1 ? 
ATOM   8935  C  C     . SER B 1 596 ? -22.994 -16.677 -86.791  1    32.264  ? 596  SER B C     1 ? 
ATOM   8936  O  O     . SER B 1 596 ? -22.965 -16.211 -85.655  1    35.995  ? 596  SER B O     1 ? 
ATOM   8937  C  CB    . SER B 1 596 ? -23.045 -15.024 -88.707  1    34.158  ? 596  SER B CB    1 ? 
ATOM   8938  O  OG    . SER B 1 596 ? -21.791 -15.529 -89.106  1    39.334  ? 596  SER B OG    1 ? 
ATOM   8939  N  N     . GLU B 1 597 ? -22.278 -17.753 -87.166  1    33.377  ? 597  GLU B N     1 ? 
ATOM   8940  C  CA    . GLU B 1 597 ? -21.773 -18.743 -86.21   1    32.598  ? 597  GLU B CA    1 ? 
ATOM   8941  C  C     . GLU B 1 597 ? -20.374 -18.411 -85.692  1    32.486  ? 597  GLU B C     1 ? 
ATOM   8942  O  O     . GLU B 1 597 ? -19.604 -17.697 -86.334  1    32.744  ? 597  GLU B O     1 ? 
ATOM   8943  C  CB    . GLU B 1 597 ? -21.672 -20.149 -86.809  1    28.656  ? 597  GLU B CB    1 ? 
ATOM   8944  C  CG    . GLU B 1 597 ? -23.042 -20.756 -87.104  1    30.416  ? 597  GLU B CG    1 ? 
ATOM   8945  C  CD    . GLU B 1 597 ? -23.833 -20.177 -88.275  1    36.877  ? 597  GLU B CD    1 ? 
ATOM   8946  O  OE1   . GLU B 1 597 ? -23.287 -19.43  -89.142  1    38.692  ? 597  GLU B OE1   1 ? 
ATOM   8947  O  OE2   . GLU B 1 597 ? -25.046 -20.465 -88.285  1    37.042  ? 597  GLU B OE2   1 ? 
ATOM   8948  N  N     . CYS B 1 598 ? -20.058 -18.968 -84.517  1    35.093  ? 598  CYS B N     1 ? 
ATOM   8949  C  CA    . CYS B 1 598 ? -18.72  -18.96  -83.925  1    30.053  ? 598  CYS B CA    1 ? 
ATOM   8950  C  C     . CYS B 1 598 ? -17.799 -19.833 -84.784  1    34.873  ? 598  CYS B C     1 ? 
ATOM   8951  O  O     . CYS B 1 598 ? -18.244 -20.852 -85.315  1    33.978  ? 598  CYS B O     1 ? 
ATOM   8952  C  CB    . CYS B 1 598 ? -18.825 -19.358 -82.447  1    29.515  ? 598  CYS B CB    1 ? 
ATOM   8953  S  SG    . CYS B 1 598 ? -17.236 -19.688 -81.628  1    33.545  ? 598  CYS B SG    1 ? 
ATOM   8954  N  N     . LEU B 1 599 ? -16.527 -19.416 -84.936  1    33.107  ? 599  LEU B N     1 ? 
ATOM   8955  C  CA    . LEU B 1 599 ? -15.521 -20.154 -85.699  1    36.059  ? 599  LEU B CA    1 ? 
ATOM   8956  C  C     . LEU B 1 599 ? -14.554 -20.856 -84.747  1    35.676  ? 599  LEU B C     1 ? 
ATOM   8957  O  O     . LEU B 1 599 ? -14.072 -20.264 -83.784  1    38.226  ? 599  LEU B O     1 ? 
ATOM   8958  C  CB    . LEU B 1 599 ? -14.731 -19.29  -86.694  1    38.377  ? 599  LEU B CB    1 ? 
ATOM   8959  C  CG    . LEU B 1 599 ? -15.525 -18.524 -87.77   1    50.358  ? 599  LEU B CG    1 ? 
ATOM   8960  C  CD1   . LEU B 1 599 ? -14.69  -17.462 -88.532  1    40.361  ? 599  LEU B CD1   1 ? 
ATOM   8961  C  CD2   . LEU B 1 599 ? -16.224 -19.471 -88.764  1    50.382  ? 599  LEU B CD2   1 ? 
ATOM   8962  N  N     . MET B 1 600 ? -14.204 -22.102 -85.064  1    35.329  ? 600  MET B N     1 ? 
ATOM   8963  C  CA    . MET B 1 600 ? -13.142 -22.811 -84.369  1    37.667  ? 600  MET B CA    1 ? 
ATOM   8964  C  C     . MET B 1 600 ? -12.008 -23.044 -85.367  1    36.248  ? 600  MET B C     1 ? 
ATOM   8965  O  O     . MET B 1 600 ? -12.254 -23.614 -86.422  1    41.875  ? 600  MET B O     1 ? 
ATOM   8966  C  CB    . MET B 1 600 ? -13.687 -24.132 -83.79   1    36.438  ? 600  MET B CB    1 ? 
ATOM   8967  C  CG    . MET B 1 600 ? -12.626 -25.067 -83.236  1    38.524  ? 600  MET B CG    1 ? 
ATOM   8968  S  SD    . MET B 1 600 ? -13.405 -26.612 -82.72   1    45.622  ? 600  MET B SD    1 ? 
ATOM   8969  C  CE    . MET B 1 600 ? -11.924 -27.488 -82.205  1    49.096  ? 600  MET B CE    1 ? 
ATOM   8970  N  N     . CYS B 1 601 ? -10.784 -22.597 -85.061  1    31.529  ? 601  CYS B N     1 ? 
ATOM   8971  C  CA    . CYS B 1 601 ? -9.732  -22.502 -86.071  1    33.269  ? 601  CYS B CA    1 ? 
ATOM   8972  C  C     . CYS B 1 601 ? -8.435  -23.064 -85.494  1    38.181  ? 601  CYS B C     1 ? 
ATOM   8973  O  O     . CYS B 1 601 ? -8.176  -22.888 -84.301  1    39.941  ? 601  CYS B O     1 ? 
ATOM   8974  C  CB    . CYS B 1 601 ? -9.347  -21.049 -86.366  1    38.691  ? 601  CYS B CB    1 ? 
ATOM   8975  S  SG    . CYS B 1 601 ? -10.738 -19.99  -86.838  1    54.855  ? 601  CYS B SG    1 ? 
ATOM   8976  N  N     . TRP B 1 602 ? -7.62   -23.706 -86.345  1    32.072  ? 602  TRP B N     1 ? 
ATOM   8977  C  CA    . TRP B 1 602 ? -6.32   -24.217 -85.937  1    34.651  ? 602  TRP B CA    1 ? 
ATOM   8978  C  C     . TRP B 1 602 ? -5.415  -24.406 -87.154  1    33.985  ? 602  TRP B C     1 ? 
ATOM   8979  O  O     . TRP B 1 602 ? -5.899  -24.531 -88.284  1    30.485  ? 602  TRP B O     1 ? 
ATOM   8980  C  CB    . TRP B 1 602 ? -6.492  -25.529 -85.153  1    39.205  ? 602  TRP B CB    1 ? 
ATOM   8981  C  CG    . TRP B 1 602 ? -7.074  -26.666 -85.95   1    39.704  ? 602  TRP B CG    1 ? 
ATOM   8982  C  CD1   . TRP B 1 602 ? -6.359  -27.623 -86.612  1    36.78   ? 602  TRP B CD1   1 ? 
ATOM   8983  C  CD2   . TRP B 1 602 ? -8.472  -26.966 -86.17   1    38.656  ? 602  TRP B CD2   1 ? 
ATOM   8984  N  NE1   . TRP B 1 602 ? -7.209  -28.503 -87.211  1    35.745  ? 602  TRP B NE1   1 ? 
ATOM   8985  C  CE2   . TRP B 1 602 ? -8.507  -28.123 -86.981  1    38.513  ? 602  TRP B CE2   1 ? 
ATOM   8986  C  CE3   . TRP B 1 602 ? -9.684  -26.367 -85.793  1    37.655  ? 602  TRP B CE3   1 ? 
ATOM   8987  C  CZ2   . TRP B 1 602 ? -9.705  -28.695 -87.409  1    37.785  ? 602  TRP B CZ2   1 ? 
ATOM   8988  C  CZ3   . TRP B 1 602 ? -10.871 -26.93  -86.215  1    35.852  ? 602  TRP B CZ3   1 ? 
ATOM   8989  C  CH2   . TRP B 1 602 ? -10.876 -28.075 -87.017  1    41.85   ? 602  TRP B CH2   1 ? 
ATOM   8990  N  N     . TYR B 1 603 ? -4.102  -24.392 -86.905  1    33.582  ? 603  TYR B N     1 ? 
ATOM   8991  C  CA    . TYR B 1 603 ? -3.11   -24.62  -87.948  1    41.13   ? 603  TYR B CA    1 ? 
ATOM   8992  C  C     . TYR B 1 603 ? -3.138  -26.087 -88.385  1    44.745  ? 603  TYR B C     1 ? 
ATOM   8993  O  O     . TYR B 1 603 ? -3.28   -26.987 -87.557  1    42.957  ? 603  TYR B O     1 ? 
ATOM   8994  C  CB    . TYR B 1 603 ? -1.719  -24.317 -87.387  1    39.362  ? 603  TYR B CB    1 ? 
ATOM   8995  C  CG    . TYR B 1 603 ? -0.572  -24.807 -88.262  1    45.01   ? 603  TYR B CG    1 ? 
ATOM   8996  C  CD1   . TYR B 1 603 ? -0.123  -24.051 -89.351  1    49.235  ? 603  TYR B CD1   1 ? 
ATOM   8997  C  CD2   . TYR B 1 603 ? 0.058   -26.026 -88.018  1    46.972  ? 603  TYR B CD2   1 ? 
ATOM   8998  C  CE1   . TYR B 1 603 ? 0.929   -24.478 -90.149  1    43.394  ? 603  TYR B CE1   1 ? 
ATOM   8999  C  CE2   . TYR B 1 603 ? 1.099   -26.473 -88.821  1    49.924  ? 603  TYR B CE2   1 ? 
ATOM   9000  C  CZ    . TYR B 1 603 ? 1.538   -25.692 -89.881  1    44.077  ? 603  TYR B CZ    1 ? 
ATOM   9001  O  OH    . TYR B 1 603 ? 2.563   -26.113 -90.675  1    47.214  ? 603  TYR B OH    1 ? 
ATOM   9002  N  N     . ASP B 1 604 ? -2.959  -26.322 -89.689  1    48.207  ? 604  ASP B N     1 ? 
ATOM   9003  C  CA    . ASP B 1 604 ? -2.896  -27.68  -90.213  1    49.06   ? 604  ASP B CA    1 ? 
ATOM   9004  C  C     . ASP B 1 604 ? -1.831  -27.743 -91.307  1    47.267  ? 604  ASP B C     1 ? 
ATOM   9005  O  O     . ASP B 1 604 ? -1.846  -26.934 -92.23   1    44.97   ? 604  ASP B O     1 ? 
ATOM   9006  C  CB    . ASP B 1 604 ? -4.281  -28.181 -90.587  1    51.66   ? 604  ASP B CB    1 ? 
ATOM   9007  C  CG    . ASP B 1 604 ? -4.327  -29.461 -91.413  1    52.688  ? 604  ASP B CG    1 ? 
ATOM   9008  O  OD1   . ASP B 1 604 ? -4.048  -29.384 -92.625  1    47.868  ? 604  ASP B OD1   1 ? 
ATOM   9009  O  OD2   . ASP B 1 604 ? -4.643  -30.517 -90.833  1    54.163  ? 604  ASP B OD2   1 ? 
ATOM   9010  N  N     . ARG B 1 605 ? -0.923  -28.725 -91.175  1    55.456  ? 605  ARG B N     1 ? 
ATOM   9011  C  CA    . ARG B 1 605 ? 0.265   -28.913 -92      1    49.772  ? 605  ARG B CA    1 ? 
ATOM   9012  C  C     . ARG B 1 605 ? -0.123  -29.234 -93.444  1    50.221  ? 605  ARG B C     1 ? 
ATOM   9013  O  O     . ARG B 1 605 ? 0.72    -29.22  -94.33   1    46.674  ? 605  ARG B O     1 ? 
ATOM   9014  C  CB    . ARG B 1 605 ? 1.167   -30.006 -91.404  1    47.413  ? 605  ARG B CB    1 ? 
ATOM   9015  C  CG    . ARG B 1 605 ? 0.5     -31.334 -91.077  1    49.328  ? 605  ARG B CG    1 ? 
ATOM   9016  C  CD    . ARG B 1 605 ? 1.502   -32.389 -90.618  1    55.012  ? 605  ARG B CD    1 ? 
ATOM   9017  N  NE    . ARG B 1 605 ? 0.838   -33.676 -90.37   1    58.622  ? 605  ARG B NE    1 ? 
ATOM   9018  C  CZ    . ARG B 1 605 ? 0.252   -34.496 -91.254  1    64.642  ? 605  ARG B CZ    1 ? 
ATOM   9019  N  NH1   . ARG B 1 605 ? 0.413   -34.343 -92.558  1    54.537  ? 605  ARG B NH1   1 ? 
ATOM   9020  N  NH2   . ARG B 1 605 ? -0.471  -35.515 -90.823  1    64.681  ? 605  ARG B NH2   1 ? 
ATOM   9021  N  N     . ASP B 1 606 ? -1.416  -29.469 -93.67   1    46.203  ? 606  ASP B N     1 ? 
ATOM   9022  C  CA    . ASP B 1 606 ? -1.9    -30.106 -94.879  1    56.273  ? 606  ASP B CA    1 ? 
ATOM   9023  C  C     . ASP B 1 606 ? -2.971  -29.203 -95.503  1    62.765  ? 606  ASP B C     1 ? 
ATOM   9024  O  O     . ASP B 1 606 ? -3.903  -29.698 -96.15   1    58.137  ? 606  ASP B O     1 ? 
ATOM   9025  C  CB    . ASP B 1 606 ? -2.214  -31.561 -94.544  1    56.197  ? 606  ASP B CB    1 ? 
ATOM   9026  C  CG    . ASP B 1 606 ? -2.835  -32.422 -95.632  1    65.19   ? 606  ASP B CG    1 ? 
ATOM   9027  O  OD1   . ASP B 1 606 ? -2.429  -32.273 -96.81   1    63.205  ? 606  ASP B OD1   1 ? 
ATOM   9028  O  OD2   . ASP B 1 606 ? -3.693  -33.265 -95.277  1    68.395  ? 606  ASP B OD2   1 ? 
ATOM   9029  N  N     . THR B 1 607 ? -2.825  -27.875 -95.279  1    60.507  ? 607  THR B N     1 ? 
ATOM   9030  C  CA    . THR B 1 607 ? -3.767  -26.853 -95.744  1    55.421  ? 607  THR B CA    1 ? 
ATOM   9031  C  C     . THR B 1 607 ? -3.014  -25.705 -96.428  1    52.395  ? 607  THR B C     1 ? 
ATOM   9032  O  O     . THR B 1 607 ? -2.007  -25.199 -95.923  1    44.692  ? 607  THR B O     1 ? 
ATOM   9033  C  CB    . THR B 1 607 ? -4.661  -26.362 -94.599  1    49.765  ? 607  THR B CB    1 ? 
ATOM   9034  O  OG1   . THR B 1 607 ? -5.497  -27.459 -94.246  1    55.194  ? 607  THR B OG1   1 ? 
ATOM   9035  C  CG2   . THR B 1 607 ? -5.611  -25.244 -94.996  1    43.446  ? 607  THR B CG2   1 ? 
ATOM   9036  N  N     . GLU B 1 608 ? -3.52   -25.3   -97.6    1    50.387  ? 608  GLU B N     1 ? 
ATOM   9037  C  CA    . GLU B 1 608 ? -2.971  -24.149 -98.297  1    48.701  ? 608  GLU B CA    1 ? 
ATOM   9038  C  C     . GLU B 1 608 ? -4.032  -23.577 -99.222  1    51.29   ? 608  GLU B C     1 ? 
ATOM   9039  O  O     . GLU B 1 608 ? -4.654  -24.316 -99.981  1    52.971  ? 608  GLU B O     1 ? 
ATOM   9040  C  CB    . GLU B 1 608 ? -1.718  -24.414 -99.127  1    45.85   ? 608  GLU B CB    1 ? 
ATOM   9041  C  CG    . GLU B 1 608 ? -1.136  -23.135 -99.718  1    43.016  ? 608  GLU B CG    1 ? 
ATOM   9042  C  CD    . GLU B 1 608 ? 0.287   -23.271 -100.21  1    46.687  ? 608  GLU B CD    1 ? 
ATOM   9043  O  OE1   . GLU B 1 608 ? 1.145   -23.62  -99.389  1    49.105  ? 608  GLU B OE1   1 ? 
ATOM   9044  O  OE2   . GLU B 1 608 ? 0.542   -23.02  -101.404 1    55.662  ? 608  GLU B OE2   1 ? 
ATOM   9045  N  N     . PHE B 1 609 ? -4.23   -22.254 -99.119  1    52.815  ? 609  PHE B N     1 ? 
ATOM   9046  C  CA    . PHE B 1 609 ? -5.191  -21.524 -99.932  1    59.047  ? 609  PHE B CA    1 ? 
ATOM   9047  C  C     . PHE B 1 609 ? -4.886  -20.042 -99.766  1    60.085  ? 609  PHE B C     1 ? 
ATOM   9048  O  O     . PHE B 1 609 ? -4.085  -19.665 -98.909  1    60.548  ? 609  PHE B O     1 ? 
ATOM   9049  C  CB    . PHE B 1 609 ? -6.663  -21.88  -99.67   1    58.25   ? 609  PHE B CB    1 ? 
ATOM   9050  C  CG    . PHE B 1 609 ? -7.192  -21.482 -98.298  1    61.729  ? 609  PHE B CG    1 ? 
ATOM   9051  C  CD1   . PHE B 1 609 ? -7.027  -22.329 -97.197  1    54.435  ? 609  PHE B CD1   1 ? 
ATOM   9052  C  CD2   . PHE B 1 609 ? -7.859  -20.266 -98.117  1    56.801  ? 609  PHE B CD2   1 ? 
ATOM   9053  C  CE1   . PHE B 1 609 ? -7.511  -21.961 -95.945  1    54.966  ? 609  PHE B CE1   1 ? 
ATOM   9054  C  CE2   . PHE B 1 609 ? -8.323  -19.892 -96.859  1    49.148  ? 609  PHE B CE2   1 ? 
ATOM   9055  C  CZ    . PHE B 1 609 ? -8.151  -20.741 -95.779  1    45.72   ? 609  PHE B CZ    1 ? 
ATOM   9056  N  N     . ILE B 1 610 ? -5.513  -19.229 -100.621 1    58.564  ? 610  ILE B N     1 ? 
ATOM   9057  C  CA    . ILE B 1 610 ? -5.315  -17.791 -100.582 1    58.428  ? 610  ILE B CA    1 ? 
ATOM   9058  C  C     . ILE B 1 610 ? -6.441  -17.166 -99.757  1    51.627  ? 610  ILE B C     1 ? 
ATOM   9059  O  O     . ILE B 1 610 ? -7.626  -17.39  -100.033 1    47.336  ? 610  ILE B O     1 ? 
ATOM   9060  C  CB    . ILE B 1 610 ? -5.159  -17.205 -102     1    60.916  ? 610  ILE B CB    1 ? 
ATOM   9061  C  CG1   . ILE B 1 610 ? -3.869  -17.726 -102.661 1    61.25   ? 610  ILE B CG1   1 ? 
ATOM   9062  C  CG2   . ILE B 1 610 ? -5.18   -15.673 -101.961 1    62.416  ? 610  ILE B CG2   1 ? 
ATOM   9063  C  CD1   . ILE B 1 610 ? -3.775  -17.5   -104.161 1    63.291  ? 610  ILE B CD1   1 ? 
ATOM   9064  N  N     . TYR B 1 611 ? -6.03   -16.477 -98.678  1    51.519  ? 611  TYR B N     1 ? 
ATOM   9065  C  CA    . TYR B 1 611 ? -6.92   -15.711 -97.815  1    51.801  ? 611  TYR B CA    1 ? 
ATOM   9066  C  C     . TYR B 1 611 ? -6.795  -14.241 -98.227  1    45.321  ? 611  TYR B C     1 ? 
ATOM   9067  O  O     . TYR B 1 611 ? -5.722  -13.652 -98.096  1    47.848  ? 611  TYR B O     1 ? 
ATOM   9068  C  CB    . TYR B 1 611 ? -6.724  -15.968 -96.31   1    46.865  ? 611  TYR B CB    1 ? 
ATOM   9069  C  CG    . TYR B 1 611 ? -7.871  -15.46  -95.439  1    50.027  ? 611  TYR B CG    1 ? 
ATOM   9070  C  CD1   . TYR B 1 611 ? -7.921  -14.14  -94.979  1    49.048  ? 611  TYR B CD1   1 ? 
ATOM   9071  C  CD2   . TYR B 1 611 ? -8.939  -16.297 -95.113  1    52.896  ? 611  TYR B CD2   1 ? 
ATOM   9072  C  CE1   . TYR B 1 611 ? -8.989  -13.69  -94.204  1    55.385  ? 611  TYR B CE1   1 ? 
ATOM   9073  C  CE2   . TYR B 1 611 ? -10.004 -15.859 -94.338  1    57.889  ? 611  TYR B CE2   1 ? 
ATOM   9074  C  CZ    . TYR B 1 611 ? -10.031 -14.549 -93.882  1    54.82   ? 611  TYR B CZ    1 ? 
ATOM   9075  O  OH    . TYR B 1 611 ? -11.107 -14.155 -93.139  1    49.55   ? 611  TYR B OH    1 ? 
ATOM   9076  N  N     . PRO B 1 612 ? -7.866  -13.641 -98.804  1    50.675  ? 612  PRO B N     1 ? 
ATOM   9077  C  CA    . PRO B 1 612 ? -7.799  -12.271 -99.324  1    54.342  ? 612  PRO B CA    1 ? 
ATOM   9078  C  C     . PRO B 1 612 ? -7.728  -11.23  -98.206  1    61.1    ? 612  PRO B C     1 ? 
ATOM   9079  O  O     . PRO B 1 612 ? -8.443  -11.346 -97.202  1    56.648  ? 612  PRO B O     1 ? 
ATOM   9080  C  CB    . PRO B 1 612 ? -9.118  -12.165 -100.125 1    59.005  ? 612  PRO B CB    1 ? 
ATOM   9081  C  CG    . PRO B 1 612 ? -10.077 -13.107 -99.411  1    56.757  ? 612  PRO B CG    1 ? 
ATOM   9082  C  CD    . PRO B 1 612 ? -9.196  -14.259 -98.959  1    46.715  ? 612  PRO B CD    1 ? 
ATOM   9083  N  N     . SER B 1 613 ? -6.865  -10.218 -98.39   1    62.164  ? 613  SER B N     1 ? 
ATOM   9084  C  CA    . SER B 1 613 ? -6.818  -9.062  -97.501  1    62.518  ? 613  SER B CA    1 ? 
ATOM   9085  C  C     . SER B 1 613 ? -8.212  -8.449  -97.361  1    59.539  ? 613  SER B C     1 ? 
ATOM   9086  O  O     . SER B 1 613 ? -8.976  -8.399  -98.321  1    60.332  ? 613  SER B O     1 ? 
ATOM   9087  C  CB    . SER B 1 613 ? -5.813  -8.034  -97.969  1    64.548  ? 613  SER B CB    1 ? 
ATOM   9088  O  OG    . SER B 1 613 ? -5.78   -6.906  -97.099  1    58.924  ? 613  SER B OG    1 ? 
ATOM   9089  N  N     . PRO B 1 614 ? -8.614  -8.008  -96.148  1    57.966  ? 614  PRO B N     1 ? 
ATOM   9090  C  CA    . PRO B 1 614 ? -9.897  -7.314  -95.982  1    58.187  ? 614  PRO B CA    1 ? 
ATOM   9091  C  C     . PRO B 1 614 ? -9.854  -5.883  -96.529  1    62.415  ? 614  PRO B C     1 ? 
ATOM   9092  O  O     . PRO B 1 614 ? -10.89  -5.325  -96.882  1    66.96   ? 614  PRO B O     1 ? 
ATOM   9093  C  CB    . PRO B 1 614 ? -10.185 -7.373  -94.465  1    45.577  ? 614  PRO B CB    1 ? 
ATOM   9094  C  CG    . PRO B 1 614 ? -8.846  -7.685  -93.823  1    47.303  ? 614  PRO B CG    1 ? 
ATOM   9095  C  CD    . PRO B 1 614 ? -7.864  -8.159  -94.888  1    51.467  ? 614  PRO B CD    1 ? 
ATOM   9096  N  N     . TRP B 1 615 ? -8.636  -5.323  -96.619  1    61.018  ? 615  TRP B N     1 ? 
ATOM   9097  C  CA    . TRP B 1 615 ? -8.354  -3.979  -97.108  1    61.797  ? 615  TRP B CA    1 ? 
ATOM   9098  C  C     . TRP B 1 615 ? -6.987  -3.991  -97.801  1    58.252  ? 615  TRP B C     1 ? 
ATOM   9099  O  O     . TRP B 1 615 ? -5.955  -3.754  -97.158  1    52.074  ? 615  TRP B O     1 ? 
ATOM   9100  C  CB    . TRP B 1 615 ? -8.346  -3.022  -95.907  1    63.523  ? 615  TRP B CB    1 ? 
ATOM   9101  C  CG    . TRP B 1 615 ? -8.468  -1.551  -96.212  1    74.93   ? 615  TRP B CG    1 ? 
ATOM   9102  C  CD1   . TRP B 1 615 ? -8.54   -0.944  -97.433  1    73.323  ? 615  TRP B CD1   1 ? 
ATOM   9103  C  CD2   . TRP B 1 615 ? -8.507  -0.487  -95.231  1    73.391  ? 615  TRP B CD2   1 ? 
ATOM   9104  N  NE1   . TRP B 1 615 ? -8.637  0.414   -97.28   1    75.409  ? 615  TRP B NE1   1 ? 
ATOM   9105  C  CE2   . TRP B 1 615 ? -8.613  0.726   -95.945  1    76.005  ? 615  TRP B CE2   1 ? 
ATOM   9106  C  CE3   . TRP B 1 615 ? -8.468  -0.441  -93.833  1    71.666  ? 615  TRP B CE3   1 ? 
ATOM   9107  C  CZ2   . TRP B 1 615 ? -8.68   1.96    -95.301  1    76.268  ? 615  TRP B CZ2   1 ? 
ATOM   9108  C  CZ3   . TRP B 1 615 ? -8.53   0.78    -93.197  1    81.429  ? 615  TRP B CZ3   1 ? 
ATOM   9109  C  CH2   . TRP B 1 615 ? -8.631  1.965   -93.925  1    79.534  ? 615  TRP B CH2   1 ? 
ATOM   9110  N  N     . PRO B 1 616 ? -6.911  -4.345  -99.112  1    58.686  ? 616  PRO B N     1 ? 
ATOM   9111  C  CA    . PRO B 1 616 ? -5.616  -4.494  -99.799  1    56.976  ? 616  PRO B CA    1 ? 
ATOM   9112  C  C     . PRO B 1 616 ? -4.551  -3.404  -99.621  1    64.435  ? 616  PRO B C     1 ? 
ATOM   9113  O  O     . PRO B 1 616 ? -3.359  -3.709  -99.564  1    63.907  ? 616  PRO B O     1 ? 
ATOM   9114  C  CB    . PRO B 1 616 ? -5.988  -4.716  -101.279 1    52.723  ? 616  PRO B CB    1 ? 
ATOM   9115  C  CG    . PRO B 1 616 ? -7.412  -5.254  -101.231 1    55.201  ? 616  PRO B CG    1 ? 
ATOM   9116  C  CD    . PRO B 1 616 ? -8.062  -4.666  -99.977  1    54.002  ? 616  PRO B CD    1 ? 
ATOM   9117  N  N     . GLU B 1 617 ? -4.976  -2.136  -99.51   1    68.869  ? 617  GLU B N     1 ? 
ATOM   9118  C  CA    . GLU B 1 617 ? -4.047  -1.012  -99.458  1    68.032  ? 617  GLU B CA    1 ? 
ATOM   9119  C  C     . GLU B 1 617 ? -3.282  -0.968  -98.136  1    71.583  ? 617  GLU B C     1 ? 
ATOM   9120  O  O     . GLU B 1 617 ? -2.229  -0.339  -98.064  1    67.271  ? 617  GLU B O     1 ? 
ATOM   9121  C  CB    . GLU B 1 617 ? -4.721  0.342   -99.671  1    74.155  ? 617  GLU B CB    1 ? 
ATOM   9122  C  CG    . GLU B 1 617 ? -5.331  0.496   -101.06  1    83.014  ? 617  GLU B CG    1 ? 
ATOM   9123  C  CD    . GLU B 1 617 ? -6.748  -0.025  -101.225 1    84.631  ? 617  GLU B CD    1 ? 
ATOM   9124  O  OE1   . GLU B 1 617 ? -7.118  -1.116  -100.712 1    76.49   ? 617  GLU B OE1   1 ? 
ATOM   9125  O  OE2   . GLU B 1 617 ? -7.481  0.702   -101.924 1    89.925  ? 617  GLU B OE2   1 ? 
ATOM   9126  N  N     . LYS B 1 618 ? -3.794  -1.641  -97.097  1    65.752  ? 618  LYS B N     1 ? 
ATOM   9127  C  CA    . LYS B 1 618 ? -3.186  -1.526  -95.779  1    70.65   ? 618  LYS B CA    1 ? 
ATOM   9128  C  C     . LYS B 1 618 ? -2.534  -2.838  -95.328  1    68.266  ? 618  LYS B C     1 ? 
ATOM   9129  O  O     . LYS B 1 618 ? -1.56   -2.821  -94.571  1    71.071  ? 618  LYS B O     1 ? 
ATOM   9130  C  CB    . LYS B 1 618 ? -4.201  -0.931  -94.791  1    80.177  ? 618  LYS B CB    1 ? 
ATOM   9131  C  CG    . LYS B 1 618 ? -4.665  0.5     -95.054  1    79.07   ? 618  LYS B CG    1 ? 
ATOM   9132  C  CD    . LYS B 1 618 ? -3.621  1.564   -94.729  1    83.986  ? 618  LYS B CD    1 ? 
ATOM   9133  C  CE    . LYS B 1 618 ? -4.168  2.947   -94.945  1    76.653  ? 618  LYS B CE    1 ? 
ATOM   9134  N  NZ    . LYS B 1 618 ? -3.19   4.007   -94.677  1    67.242  ? 618  LYS B NZ    1 ? 
ATOM   9135  N  N     . PHE B 1 619 ? -3.081  -3.975  -95.775  1    66.768  ? 619  PHE B N     1 ? 
ATOM   9136  C  CA    . PHE B 1 619 ? -2.642  -5.274  -95.271  1    67.686  ? 619  PHE B CA    1 ? 
ATOM   9137  C  C     . PHE B 1 619 ? -2.517  -6.277  -96.417  1    56.738  ? 619  PHE B C     1 ? 
ATOM   9138  O  O     . PHE B 1 619 ? -3.392  -6.345  -97.28   1    55.828  ? 619  PHE B O     1 ? 
ATOM   9139  C  CB    . PHE B 1 619 ? -3.59   -5.869  -94.222  1    62.109  ? 619  PHE B CB    1 ? 
ATOM   9140  C  CG    . PHE B 1 619 ? -3.921  -4.935  -93.068  1    56.327  ? 619  PHE B CG    1 ? 
ATOM   9141  C  CD1   . PHE B 1 619 ? -3.041  -4.786  -91.998  1    48.464  ? 619  PHE B CD1   1 ? 
ATOM   9142  C  CD2   . PHE B 1 619 ? -5.122  -4.226  -93.064  1    54.442  ? 619  PHE B CD2   1 ? 
ATOM   9143  C  CE1   . PHE B 1 619 ? -3.348  -3.926  -90.953  1    54.77   ? 619  PHE B CE1   1 ? 
ATOM   9144  C  CE2   . PHE B 1 619 ? -5.423  -3.363  -92.021  1    51.851  ? 619  PHE B CE2   1 ? 
ATOM   9145  C  CZ    . PHE B 1 619 ? -4.54   -3.219  -90.967  1    50.152  ? 619  PHE B CZ    1 ? 
ATOM   9146  N  N     . PRO B 1 620 ? -1.455  -7.116  -96.418  1    55.914  ? 620  PRO B N     1 ? 
ATOM   9147  C  CA    . PRO B 1 620 ? -1.276  -8.13   -97.464  1    55.952  ? 620  PRO B CA    1 ? 
ATOM   9148  C  C     . PRO B 1 620 ? -2.382  -9.181  -97.45   1    58.055  ? 620  PRO B C     1 ? 
ATOM   9149  O  O     . PRO B 1 620 ? -2.979  -9.439  -96.408  1    55.607  ? 620  PRO B O     1 ? 
ATOM   9150  C  CB    . PRO B 1 620 ? 0.107   -8.75   -97.176  1    53.966  ? 620  PRO B CB    1 ? 
ATOM   9151  C  CG    . PRO B 1 620 ? 0.752   -7.821  -96.164  1    58.61   ? 620  PRO B CG    1 ? 
ATOM   9152  C  CD    . PRO B 1 620 ? -0.376  -7.115  -95.412  1    50.876  ? 620  PRO B CD    1 ? 
ATOM   9153  N  N     . ALA B 1 621 ? -2.657  -9.775  -98.618  1    63.247  ? 621  ALA B N     1 ? 
ATOM   9154  C  CA    . ALA B 1 621 ? -3.391  -11.031 -98.673  1    60.732  ? 621  ALA B CA    1 ? 
ATOM   9155  C  C     . ALA B 1 621 ? -2.535  -12.116 -98.01   1    58.961  ? 621  ALA B C     1 ? 
ATOM   9156  O  O     . ALA B 1 621 ? -1.322  -11.936 -97.822  1    56.76   ? 621  ALA B O     1 ? 
ATOM   9157  C  CB    . ALA B 1 621 ? -3.771  -11.369 -100.109 1    50.586  ? 621  ALA B CB    1 ? 
ATOM   9158  N  N     . ILE B 1 622 ? -3.181  -13.217 -97.596  1    48.253  ? 622  ILE B N     1 ? 
ATOM   9159  C  CA    . ILE B 1 622 ? -2.43   -14.347 -97.063  1    49.531  ? 622  ILE B CA    1 ? 
ATOM   9160  C  C     . ILE B 1 622 ? -2.248  -15.358 -98.192  1    50.799  ? 622  ILE B C     1 ? 
ATOM   9161  O  O     . ILE B 1 622 ? -3.2    -16.049 -98.586  1    45.059  ? 622  ILE B O     1 ? 
ATOM   9162  C  CB    . ILE B 1 622 ? -3.13   -14.962 -95.837  1    45.5    ? 622  ILE B CB    1 ? 
ATOM   9163  C  CG1   . ILE B 1 622 ? -3.494  -13.89  -94.793  1    41.557  ? 622  ILE B CG1   1 ? 
ATOM   9164  C  CG2   . ILE B 1 622 ? -2.303  -16.101 -95.234  1    45.677  ? 622  ILE B CG2   1 ? 
ATOM   9165  C  CD1   . ILE B 1 622 ? -4.255  -14.43  -93.586  1    36.089  ? 622  ILE B CD1   1 ? 
ATOM   9166  N  N     . GLU B 1 623 ? -1.022  -15.375 -98.73   1    63.597  ? 623  GLU B N     1 ? 
ATOM   9167  C  CA    . GLU B 1 623 ? -0.636  -16.211 -99.863  1    71.389  ? 623  GLU B CA    1 ? 
ATOM   9168  C  C     . GLU B 1 623 ? -0.959  -17.674 -99.551  1    63.653  ? 623  GLU B C     1 ? 
ATOM   9169  O  O     . GLU B 1 623 ? -1.712  -18.326 -100.281 1    55.57   ? 623  GLU B O     1 ? 
ATOM   9170  C  CB    . GLU B 1 623 ? 0.875   -16.094 -100.096 1    80.141  ? 623  GLU B CB    1 ? 
ATOM   9171  C  CG    . GLU B 1 623 ? 1.383   -14.676 -100.348 1    92.004  ? 623  GLU B CG    1 ? 
ATOM   9172  C  CD    . GLU B 1 623 ? 1.208   -14.206 -101.782 1    100.421 ? 623  GLU B CD    1 ? 
ATOM   9173  O  OE1   . GLU B 1 623 ? 1.624   -14.96  -102.696 1    95.943  ? 623  GLU B OE1   1 ? 
ATOM   9174  O  OE2   . GLU B 1 623 ? 0.675   -13.088 -101.983 1    103.103 ? 623  GLU B OE2   1 ? 
ATOM   9175  N  N     . ARG B 1 624 ? -0.406  -18.144 -98.419  1    50.928  ? 624  ARG B N     1 ? 
ATOM   9176  C  CA    . ARG B 1 624 ? -0.348  -19.547 -98.054  1    45.66   ? 624  ARG B CA    1 ? 
ATOM   9177  C  C     . ARG B 1 624 ? -0.979  -19.702 -96.677  1    45.697  ? 624  ARG B C     1 ? 
ATOM   9178  O  O     . ARG B 1 624 ? -0.266  -19.758 -95.675  1    44.704  ? 624  ARG B O     1 ? 
ATOM   9179  C  CB    . ARG B 1 624 ? 1.132   -19.956 -98.075  1    47.253  ? 624  ARG B CB    1 ? 
ATOM   9180  C  CG    . ARG B 1 624 ? 1.787   -20.106 -99.447  1    46.079  ? 624  ARG B CG    1 ? 
ATOM   9181  C  CD    . ARG B 1 624 ? 3.297   -20.325 -99.337  1    51.931  ? 624  ARG B CD    1 ? 
ATOM   9182  N  NE    . ARG B 1 624 ? 3.996   -19.051 -99.534  1    63.855  ? 624  ARG B NE    1 ? 
ATOM   9183  C  CZ    . ARG B 1 624 ? 4.893   -18.544 -98.713  1    69.181  ? 624  ARG B CZ    1 ? 
ATOM   9184  N  NH1   . ARG B 1 624 ? 5.305   -19.247 -97.676  1    69.094  ? 624  ARG B NH1   1 ? 
ATOM   9185  N  NH2   . ARG B 1 624 ? 5.38    -17.341 -98.947  1    73.611  ? 624  ARG B NH2   1 ? 
ATOM   9186  N  N     . CYS B 1 625 ? -2.319  -19.758 -96.654  1    44.981  ? 625  CYS B N     1 ? 
ATOM   9187  C  CA    . CYS B 1 625 ? -3.097  -19.804 -95.421  1    43.626  ? 625  CYS B CA    1 ? 
ATOM   9188  C  C     . CYS B 1 625 ? -3.306  -21.259 -94.99   1    43.224  ? 625  CYS B C     1 ? 
ATOM   9189  O  O     . CYS B 1 625 ? -3.849  -22.064 -95.755  1    42.694  ? 625  CYS B O     1 ? 
ATOM   9190  C  CB    . CYS B 1 625 ? -4.442  -19.106 -95.612  1    45.291  ? 625  CYS B CB    1 ? 
ATOM   9191  S  SG    . CYS B 1 625 ? -5.426  -18.972 -94.091  1    48.085  ? 625  CYS B SG    1 ? 
ATOM   9192  N  N     . CYS B 1 626 ? -2.906  -21.588 -93.752  1    39.294  ? 626  CYS B N     1 ? 
ATOM   9193  C  CA    . CYS B 1 626 ? -2.917  -22.974 -93.31   1    40.401  ? 626  CYS B CA    1 ? 
ATOM   9194  C  C     . CYS B 1 626 ? -4.04   -23.242 -92.311  1    43.514  ? 626  CYS B C     1 ? 
ATOM   9195  O  O     . CYS B 1 626 ? -3.931  -24.143 -91.487  1    44.241  ? 626  CYS B O     1 ? 
ATOM   9196  C  CB    . CYS B 1 626 ? -1.654  -23.31  -92.542  1    42.065  ? 626  CYS B CB    1 ? 
ATOM   9197  S  SG    . CYS B 1 626 ? -0.172  -22.641 -93.322  1    47.983  ? 626  CYS B SG    1 ? 
ATOM   9198  N  N     . THR B 1 627 ? -5.119  -22.458 -92.365  1    41.872  ? 627  THR B N     1 ? 
ATOM   9199  C  CA    . THR B 1 627 ? -6.093  -22.562 -91.302  1    37.932  ? 627  THR B CA    1 ? 
ATOM   9200  C  C     . THR B 1 627 ? -7.102  -23.646 -91.661  1    42.984  ? 627  THR B C     1 ? 
ATOM   9201  O  O     . THR B 1 627 ? -7.656  -23.633 -92.762  1    45.518  ? 627  THR B O     1 ? 
ATOM   9202  C  CB    . THR B 1 627 ? -6.806  -21.227 -91.139  1    39.732  ? 627  THR B CB    1 ? 
ATOM   9203  O  OG1   . THR B 1 627 ? -5.811  -20.216 -90.972  1    33.705  ? 627  THR B OG1   1 ? 
ATOM   9204  C  CG2   . THR B 1 627 ? -7.823  -21.306 -90.016  1    41.409  ? 627  THR B CG2   1 ? 
ATOM   9205  N  N     . ARG B 1 628 ? -7.349  -24.552 -90.708  1    37.588  ? 628  ARG B N     1 ? 
ATOM   9206  C  CA    . ARG B 1 628 ? -8.504  -25.429 -90.782  1    41.735  ? 628  ARG B CA    1 ? 
ATOM   9207  C  C     . ARG B 1 628 ? -9.557  -24.926 -89.793  1    40.945  ? 628  ARG B C     1 ? 
ATOM   9208  O  O     . ARG B 1 628 ? -9.222  -24.388 -88.742  1    47.188  ? 628  ARG B O     1 ? 
ATOM   9209  C  CB    . ARG B 1 628 ? -8.15   -26.922 -90.684  1    48.207  ? 628  ARG B CB    1 ? 
ATOM   9210  C  CG    . ARG B 1 628 ? -9.378  -27.796 -90.929  1    58.263  ? 628  ARG B CG    1 ? 
ATOM   9211  C  CD    . ARG B 1 628 ? -9.194  -29.306 -90.803  1    69.793  ? 628  ARG B CD    1 ? 
ATOM   9212  N  NE    . ARG B 1 628 ? -8.425  -29.974 -91.861  1    85.96   ? 628  ARG B NE    1 ? 
ATOM   9213  C  CZ    . ARG B 1 628 ? -8.003  -31.244 -91.815  1    87.696  ? 628  ARG B CZ    1 ? 
ATOM   9214  N  NH1   . ARG B 1 628 ? -8.181  -31.967 -90.717  1    85.357  ? 628  ARG B NH1   1 ? 
ATOM   9215  N  NH2   . ARG B 1 628 ? -7.382  -31.779 -92.855  1    71.989  ? 628  ARG B NH2   1 ? 
ATOM   9216  N  N     . TYR B 1 629 ? -10.827 -25.072 -90.167  1    42.297  ? 629  TYR B N     1 ? 
ATOM   9217  C  CA    . TYR B 1 629 ? -11.936 -24.438 -89.486  1    43.304  ? 629  TYR B CA    1 ? 
ATOM   9218  C  C     . TYR B 1 629 ? -12.975 -25.512 -89.225  1    42.333  ? 629  TYR B C     1 ? 
ATOM   9219  O  O     . TYR B 1 629 ? -13.131 -26.413 -90.028  1    42.161  ? 629  TYR B O     1 ? 
ATOM   9220  C  CB    . TYR B 1 629 ? -12.772 -23.56  -90.427  1    57.685  ? 629  TYR B CB    1 ? 
ATOM   9221  C  CG    . TYR B 1 629 ? -12.081 -22.415 -91.151  1    83.183  ? 629  TYR B CG    1 ? 
ATOM   9222  C  CD1   . TYR B 1 629 ? -11.983 -21.159 -90.553  1    96.367  ? 629  TYR B CD1   1 ? 
ATOM   9223  C  CD2   . TYR B 1 629 ? -11.571 -22.57  -92.439  1    83.321  ? 629  TYR B CD2   1 ? 
ATOM   9224  C  CE1   . TYR B 1 629 ? -11.367 -20.095 -91.194  1    94.17   ? 629  TYR B CE1   1 ? 
ATOM   9225  C  CE2   . TYR B 1 629 ? -10.954 -21.509 -93.09   1    98.191  ? 629  TYR B CE2   1 ? 
ATOM   9226  C  CZ    . TYR B 1 629 ? -10.852 -20.272 -92.467  1    95.013  ? 629  TYR B CZ    1 ? 
ATOM   9227  O  OH    . TYR B 1 629 ? -10.253 -19.209 -93.078  1    85.023  ? 629  TYR B OH    1 ? 
ATOM   9228  N  N     . LYS B 1 630 ? -13.696 -25.362 -88.117  1    39.466  ? 630  LYS B N     1 ? 
ATOM   9229  C  CA    . LYS B 1 630 ? -14.978 -25.994 -87.874  1    40.634  ? 630  LYS B CA    1 ? 
ATOM   9230  C  C     . LYS B 1 630 ? -15.928 -24.866 -87.47   1    42.565  ? 630  LYS B C     1 ? 
ATOM   9231  O  O     . LYS B 1 630 ? -15.585 -24.025 -86.635  1    40.823  ? 630  LYS B O     1 ? 
ATOM   9232  C  CB    . LYS B 1 630 ? -14.829 -27.079 -86.8    1    41.208  ? 630  LYS B CB    1 ? 
ATOM   9233  C  CG    . LYS B 1 630 ? -16.131 -27.735 -86.357  1    50.093  ? 630  LYS B CG    1 ? 
ATOM   9234  C  CD    . LYS B 1 630 ? -15.953 -28.643 -85.144  1    66.427  ? 630  LYS B CD    1 ? 
ATOM   9235  C  CE    . LYS B 1 630 ? -17.25  -28.977 -84.463  1    70.307  ? 630  LYS B CE    1 ? 
ATOM   9236  N  NZ    . LYS B 1 630 ? -17.032 -30.054 -83.497  1    76.531  ? 630  LYS B NZ    1 ? 
ATOM   9237  N  N     . ILE B 1 631 ? -17.089 -24.798 -88.119  1    38.685  ? 631  ILE B N     1 ? 
ATOM   9238  C  CA    . ILE B 1 631 ? -18.084 -23.807 -87.758  1    35.565  ? 631  ILE B CA    1 ? 
ATOM   9239  C  C     . ILE B 1 631 ? -18.945 -24.415 -86.661  1    39.851  ? 631  ILE B C     1 ? 
ATOM   9240  O  O     . ILE B 1 631 ? -19.312 -25.581 -86.789  1    36.654  ? 631  ILE B O     1 ? 
ATOM   9241  C  CB    . ILE B 1 631 ? -18.887 -23.381 -88.998  1    38.872  ? 631  ILE B CB    1 ? 
ATOM   9242  C  CG1   . ILE B 1 631 ? -17.968 -22.644 -89.981  1    37.136  ? 631  ILE B CG1   1 ? 
ATOM   9243  C  CG2   . ILE B 1 631 ? -20.089 -22.521 -88.59   1    34.631  ? 631  ILE B CG2   1 ? 
ATOM   9244  C  CD1   . ILE B 1 631 ? -18.423 -22.688 -91.426  1    34.916  ? 631  ILE B CD1   1 ? 
ATOM   9245  N  N     . ILE B 1 632 ? -19.232 -23.629 -85.601  1    32.68   ? 632  ILE B N     1 ? 
ATOM   9246  C  CA    . ILE B 1 632 ? -20.031 -24.09  -84.48   1    34.785  ? 632  ILE B CA    1 ? 
ATOM   9247  C  C     . ILE B 1 632 ? -21.476 -23.617 -84.663  1    35.852  ? 632  ILE B C     1 ? 
ATOM   9248  O  O     . ILE B 1 632 ? -21.76  -22.416 -84.723  1    37.489  ? 632  ILE B O     1 ? 
ATOM   9249  C  CB    . ILE B 1 632 ? -19.45  -23.592 -83.138  1    34.701  ? 632  ILE B CB    1 ? 
ATOM   9250  C  CG1   . ILE B 1 632 ? -17.945 -23.893 -82.949  1    34.733  ? 632  ILE B CG1   1 ? 
ATOM   9251  C  CG2   . ILE B 1 632 ? -20.295 -24.09  -81.974  1    35.698  ? 632  ILE B CG2   1 ? 
ATOM   9252  C  CD1   . ILE B 1 632 ? -17.579 -25.364 -82.904  1    36.981  ? 632  ILE B CD1   1 ? 
ATOM   9253  N  N     . SER B 1 633 ? -22.408 -24.568 -84.709  1    34.506  ? 633  SER B N     1 ? 
ATOM   9254  C  CA    . SER B 1 633 ? -23.805 -24.207 -84.879  1    36.78   ? 633  SER B CA    1 ? 
ATOM   9255  C  C     . SER B 1 633 ? -24.266 -23.31  -83.72   1    39.884  ? 633  SER B C     1 ? 
ATOM   9256  O  O     . SER B 1 633 ? -23.837 -23.473 -82.572  1    35.621  ? 633  SER B O     1 ? 
ATOM   9257  C  CB    . SER B 1 633 ? -24.666 -25.448 -85.032  1    35.605  ? 633  SER B CB    1 ? 
ATOM   9258  O  OG    . SER B 1 633 ? -24.974 -26.034 -83.779  1    46.16   ? 633  SER B OG    1 ? 
ATOM   9259  N  N     . LEU B 1 634 ? -25.168 -22.369 -84.027  1    42.085  ? 634  LEU B N     1 ? 
ATOM   9260  C  CA    . LEU B 1 634 ? -25.667 -21.421 -83.04   1    42.328  ? 634  LEU B CA    1 ? 
ATOM   9261  C  C     . LEU B 1 634 ? -26.181 -22.117 -81.766  1    49.658  ? 634  LEU B C     1 ? 
ATOM   9262  O  O     . LEU B 1 634 ? -25.872 -21.688 -80.655  1    42.21   ? 634  LEU B O     1 ? 
ATOM   9263  C  CB    . LEU B 1 634 ? -26.676 -20.462 -83.676  1    40.164  ? 634  LEU B CB    1 ? 
ATOM   9264  C  CG    . LEU B 1 634 ? -26.092 -19.413 -84.638  1    36.781  ? 634  LEU B CG    1 ? 
ATOM   9265  C  CD1   . LEU B 1 634 ? -27.219 -18.681 -85.366  1    39.64   ? 634  LEU B CD1   1 ? 
ATOM   9266  C  CD2   . LEU B 1 634 ? -25.227 -18.419 -83.881  1    32.474  ? 634  LEU B CD2   1 ? 
ATOM   9267  N  N     . ASP B 1 635 ? -26.931 -23.219 -81.877  1    48.49   ? 635  ASP B N     1 ? 
ATOM   9268  C  CA    . ASP B 1 635 ? -27.499 -23.765 -80.646  1    55.872  ? 635  ASP B CA    1 ? 
ATOM   9269  C  C     . ASP B 1 635 ? -26.556 -24.764 -79.968  1    49.795  ? 635  ASP B C     1 ? 
ATOM   9270  O  O     . ASP B 1 635 ? -26.943 -25.372 -78.97   1    49.902  ? 635  ASP B O     1 ? 
ATOM   9271  C  CB    . ASP B 1 635 ? -28.906 -24.32  -80.839  1    64.465  ? 635  ASP B CB    1 ? 
ATOM   9272  C  CG    . ASP B 1 635 ? -29.019 -25.542 -81.749  1    80.777  ? 635  ASP B CG    1 ? 
ATOM   9273  O  OD1   . ASP B 1 635 ? -28.045 -25.805 -82.511  1    67.704  ? 635  ASP B OD1   1 ? 
ATOM   9274  O  OD2   . ASP B 1 635 ? -30.069 -26.239 -81.674  1    80.382  ? 635  ASP B OD2   1 ? 
ATOM   9275  N  N     . ALA B 1 636 ? -25.324 -24.918 -80.484  1    41.148  ? 636  ALA B N     1 ? 
ATOM   9276  C  CA    . ALA B 1 636 ? -24.514 -26.093 -80.17   1    40.477  ? 636  ALA B CA    1 ? 
ATOM   9277  C  C     . ALA B 1 636 ? -24.245 -26.215 -78.671  1    43.747  ? 636  ALA B C     1 ? 
ATOM   9278  O  O     . ALA B 1 636 ? -24.284 -27.324 -78.132  1    33.955  ? 636  ALA B O     1 ? 
ATOM   9279  C  CB    . ALA B 1 636 ? -23.203 -26.106 -80.938  1    36.33   ? 636  ALA B CB    1 ? 
ATOM   9280  N  N     . TRP B 1 637 ? -23.959 -25.079 -78.018  1    34.656  ? 637  TRP B N     1 ? 
ATOM   9281  C  CA    . TRP B 1 637 ? -23.564 -25.108 -76.615  1    41.455  ? 637  TRP B CA    1 ? 
ATOM   9282  C  C     . TRP B 1 637 ? -24.708 -24.744 -75.675  1    44.031  ? 637  TRP B C     1 ? 
ATOM   9283  O  O     . TRP B 1 637 ? -24.508 -24.655 -74.465  1    47.625  ? 637  TRP B O     1 ? 
ATOM   9284  C  CB    . TRP B 1 637 ? -22.369 -24.183 -76.398  1    33.621  ? 637  TRP B CB    1 ? 
ATOM   9285  C  CG    . TRP B 1 637 ? -21.179 -24.65  -77.17   1    30.881  ? 637  TRP B CG    1 ? 
ATOM   9286  C  CD1   . TRP B 1 637 ? -20.914 -25.924 -77.575  1    33.193  ? 637  TRP B CD1   1 ? 
ATOM   9287  C  CD2   . TRP B 1 637 ? -20.067 -23.839 -77.604  1    33.105  ? 637  TRP B CD2   1 ? 
ATOM   9288  N  NE1   . TRP B 1 637 ? -19.699 -25.97  -78.219  1    33.328  ? 637  TRP B NE1   1 ? 
ATOM   9289  C  CE2   . TRP B 1 637 ? -19.164 -24.705 -78.263  1    33.338  ? 637  TRP B CE2   1 ? 
ATOM   9290  C  CE3   . TRP B 1 637 ? -19.745 -22.477 -77.501  1    34.415  ? 637  TRP B CE3   1 ? 
ATOM   9291  C  CZ2   . TRP B 1 637 ? -17.981 -24.24  -78.833  1    32.304  ? 637  TRP B CZ2   1 ? 
ATOM   9292  C  CZ3   . TRP B 1 637 ? -18.555 -22.03  -78.034  1    32.287  ? 637  TRP B CZ3   1 ? 
ATOM   9293  C  CH2   . TRP B 1 637 ? -17.685 -22.9   -78.697  1    32.92   ? 637  TRP B CH2   1 ? 
ATOM   9294  N  N     . ARG B 1 638 ? -25.901 -24.535 -76.235  1    40.331  ? 638  ARG B N     1 ? 
ATOM   9295  C  CA    . ARG B 1 638 ? -27.058 -24.206 -75.429  1    47.96   ? 638  ARG B CA    1 ? 
ATOM   9296  C  C     . ARG B 1 638 ? -27.617 -25.47  -74.762  1    54.405  ? 638  ARG B C     1 ? 
ATOM   9297  O  O     . ARG B 1 638 ? -27.893 -26.486 -75.418  1    54.232  ? 638  ARG B O     1 ? 
ATOM   9298  C  CB    . ARG B 1 638 ? -28.055 -23.434 -76.3    1    48.19   ? 638  ARG B CB    1 ? 
ATOM   9299  C  CG    . ARG B 1 638 ? -29.264 -22.966 -75.507  1    57.823  ? 638  ARG B CG    1 ? 
ATOM   9300  C  CD    . ARG B 1 638 ? -30.211 -22.226 -76.424  1    68.946  ? 638  ARG B CD    1 ? 
ATOM   9301  N  NE    . ARG B 1 638 ? -30.941 -23.098 -77.351  1    78.661  ? 638  ARG B NE    1 ? 
ATOM   9302  C  CZ    . ARG B 1 638 ? -31.865 -22.661 -78.206  1    88.659  ? 638  ARG B CZ    1 ? 
ATOM   9303  N  NH1   . ARG B 1 638 ? -32.166 -21.369 -78.27   1    88.362  ? 638  ARG B NH1   1 ? 
ATOM   9304  N  NH2   . ARG B 1 638 ? -32.48  -23.518 -79.002  1    86.851  ? 638  ARG B NH2   1 ? 
ATOM   9305  N  N     . VAL B 1 639 ? -27.778 -25.367 -73.438  1    47.96   ? 639  VAL B N     1 ? 
ATOM   9306  C  CA    . VAL B 1 639 ? -28.434 -26.372 -72.615  1    58.39   ? 639  VAL B CA    1 ? 
ATOM   9307  C  C     . VAL B 1 639 ? -29.817 -25.856 -72.208  1    58.95   ? 639  VAL B C     1 ? 
ATOM   9308  O  O     . VAL B 1 639 ? -29.98  -24.679 -71.888  1    61.213  ? 639  VAL B O     1 ? 
ATOM   9309  C  CB    . VAL B 1 639 ? -27.595 -26.779 -71.383  1    56.811  ? 639  VAL B CB    1 ? 
ATOM   9310  C  CG1   . VAL B 1 639 ? -28.379 -27.687 -70.432  1    59.987  ? 639  VAL B CG1   1 ? 
ATOM   9311  C  CG2   . VAL B 1 639 ? -26.271 -27.428 -71.778  1    52.331  ? 639  VAL B CG2   1 ? 
ATOM   9312  N  N     . ASP B 1 640 ? -30.806 -26.757 -72.244  1    55.877  ? 640  ASP B N     1 ? 
ATOM   9313  C  CA    . ASP B 1 640 ? -32.175 -26.471 -71.852  1    64.37   ? 640  ASP B CA    1 ? 
ATOM   9314  C  C     . ASP B 1 640 ? -32.324 -26.837 -70.37   1    66.666  ? 640  ASP B C     1 ? 
ATOM   9315  O  O     . ASP B 1 640 ? -31.823 -27.875 -69.939  1    68.734  ? 640  ASP B O     1 ? 
ATOM   9316  C  CB    . ASP B 1 640 ? -33.098 -27.193 -72.828  1    76.723  ? 640  ASP B CB    1 ? 
ATOM   9317  C  CG    . ASP B 1 640 ? -34.603 -27.089 -72.609  1    90.403  ? 640  ASP B CG    1 ? 
ATOM   9318  O  OD1   . ASP B 1 640 ? -35.036 -26.172 -71.868  1    83.939  ? 640  ASP B OD1   1 ? 
ATOM   9319  O  OD2   . ASP B 1 640 ? -35.332 -27.947 -73.176  1    87.651  ? 640  ASP B OD2   1 ? 
ATOM   9320  N  N     . ILE B 1 641 ? -32.99  -25.989 -69.572  1    65.382  ? 641  ILE B N     1 ? 
ATOM   9321  C  CA    . ILE B 1 641 ? -33.273 -26.362 -68.188  1    71.78   ? 641  ILE B CA    1 ? 
ATOM   9322  C  C     . ILE B 1 641 ? -34.219 -27.582 -68.144  1    79.72   ? 641  ILE B C     1 ? 
ATOM   9323  O  O     . ILE B 1 641 ? -35.425 -27.421 -68.476  1    81.735  ? 641  ILE B O     1 ? 
ATOM   9324  C  CB    . ILE B 1 641 ? -33.817 -25.172 -67.375  1    71.787  ? 641  ILE B CB    1 ? 
ATOM   9325  C  CG1   . ILE B 1 641 ? -32.696 -24.242 -66.939  1    54.003  ? 641  ILE B CG1   1 ? 
ATOM   9326  C  CG2   . ILE B 1 641 ? -34.648 -25.644 -66.177  1    79.777  ? 641  ILE B CG2   1 ? 
ATOM   9327  C  CD1   . ILE B 1 641 ? -33.195 -22.859 -66.559  1    59.751  ? 641  ILE B CD1   1 ? 
HETATM 9328  P  P1    A A3P C 2 .   ? -13.856 2.686   -19.392  0.46 45.441  ? 701  A3P A P1    1 ? 
HETATM 9329  P  P1    B A3P C 2 .   ? -16.425 4.446   -20.535  0.54 45.565  ? 701  A3P A P1    1 ? 
HETATM 9330  O  O1P   A A3P C 2 .   ? -14.153 1.198   -19.225  0.46 37.837  ? 701  A3P A O1P   1 ? 
HETATM 9331  O  O1P   B A3P C 2 .   ? -17.836 4.034   -20.985  0.54 43.518  ? 701  A3P A O1P   1 ? 
HETATM 9332  O  O2P   A A3P C 2 .   ? -13.002 3.251   -18.266  0.46 40.464  ? 701  A3P A O2P   1 ? 
HETATM 9333  O  O2P   B A3P C 2 .   ? -15.379 4.133   -21.592  0.54 49.174  ? 701  A3P A O2P   1 ? 
HETATM 9334  O  O3P   A A3P C 2 .   ? -13.317 3.028   -20.762  0.46 46.317  ? 701  A3P A O3P   1 ? 
HETATM 9335  O  O3P   B A3P C 2 .   ? -16.343 5.907   -20.063  0.54 30.356  ? 701  A3P A O3P   1 ? 
HETATM 9336  P  P2    A A3P C 2 .   ? -17.134 6.735   -15.569  0.46 30.405  ? 701  A3P A P2    1 ? 
HETATM 9337  P  P2    B A3P C 2 .   ? -17.15  7.11    -15.53   0.54 21.993  ? 701  A3P A P2    1 ? 
HETATM 9338  O  O4P   A A3P C 2 .   ? -16.889 6.146   -14.205  0.46 29.065  ? 701  A3P A O4P   1 ? 
HETATM 9339  O  O4P   B A3P C 2 .   ? -16.841 6.878   -14.089  0.54 18.936  ? 701  A3P A O4P   1 ? 
HETATM 9340  O  O5P   A A3P C 2 .   ? -16.269 7.957   -15.814  0.46 35.368  ? 701  A3P A O5P   1 ? 
HETATM 9341  O  O5P   B A3P C 2 .   ? -16.041 7.87    -16.229  0.54 26.13   ? 701  A3P A O5P   1 ? 
HETATM 9342  O  O6P   A A3P C 2 .   ? -18.599 6.993   -15.833  0.46 31.486  ? 701  A3P A O6P   1 ? 
HETATM 9343  O  O6P   B A3P C 2 .   ? -18.504 7.776   -15.732  0.54 20.47   ? 701  A3P A O6P   1 ? 
HETATM 9344  O  "O5'" A A3P C 2 .   ? -16.684 5.596   -16.644  0.46 32.705  ? 701  A3P A "O5'" 1 ? 
HETATM 9345  O  "O5'" B A3P C 2 .   ? -17.21  5.644   -16.22   0.54 25.593  ? 701  A3P A "O5'" 1 ? 
HETATM 9346  C  "C5'" A A3P C 2 .   ? -15.548 4.742   -16.333  0.46 29.828  ? 701  A3P A "C5'" 1 ? 
HETATM 9347  C  "C5'" B A3P C 2 .   ? -15.988 4.839   -16.298  0.54 24.04   ? 701  A3P A "C5'" 1 ? 
HETATM 9348  C  "C4'" A A3P C 2 .   ? -15.709 3.367   -16.94   0.46 35.144  ? 701  A3P A "C4'" 1 ? 
HETATM 9349  C  "C4'" B A3P C 2 .   ? -16.28  3.477   -16.891  0.54 29.129  ? 701  A3P A "C4'" 1 ? 
HETATM 9350  O  "O4'" A A3P C 2 .   ? -16.665 2.606   -16.157  0.46 34.394  ? 701  A3P A "O4'" 1 ? 
HETATM 9351  O  "O4'" B A3P C 2 .   ? -17.122 2.714   -15.993  0.54 26.312  ? 701  A3P A "O4'" 1 ? 
HETATM 9352  C  "C3'" A A3P C 2 .   ? -16.252 3.295   -18.369  0.46 38.153  ? 701  A3P A "C3'" 1 ? 
HETATM 9353  C  "C3'" B A3P C 2 .   ? -17.007 3.422   -18.243  0.54 31.03   ? 701  A3P A "C3'" 1 ? 
HETATM 9354  O  "O3'" A A3P C 2 .   ? -15.279 3.487   -19.406  0.46 42.226  ? 701  A3P A "O3'" 1 ? 
HETATM 9355  O  "O3'" B A3P C 2 .   ? -16.075 3.426   -19.321  0.54 33.547  ? 701  A3P A "O3'" 1 ? 
HETATM 9356  C  "C2'" A A3P C 2 .   ? -16.843 1.883   -18.405  0.46 41.16   ? 701  A3P A "C2'" 1 ? 
HETATM 9357  C  "C2'" B A3P C 2 .   ? -17.655 2.029   -18.188  0.54 34.891  ? 701  A3P A "C2'" 1 ? 
HETATM 9358  O  "O2'" A A3P C 2 .   ? -15.851 0.933   -18.747  0.46 37.015  ? 701  A3P A "O2'" 1 ? 
HETATM 9359  O  "O2'" B A3P C 2 .   ? -16.775 0.959   -18.481  0.54 41.826  ? 701  A3P A "O2'" 1 ? 
HETATM 9360  C  "C1'" A A3P C 2 .   ? -17.409 1.737   -16.988  0.46 37.935  ? 701  A3P A "C1'" 1 ? 
HETATM 9361  C  "C1'" B A3P C 2 .   ? -18.056 1.945   -16.721  0.54 29.687  ? 701  A3P A "C1'" 1 ? 
HETATM 9362  N  N9    A A3P C 2 .   ? -18.828 2.076   -16.787  0.46 41.286  ? 701  A3P A N9    1 ? 
HETATM 9363  N  N9    B A3P C 2 .   ? -19.402 2.443   -16.408  0.54 28.843  ? 701  A3P A N9    1 ? 
HETATM 9364  C  C8    A A3P C 2 .   ? -19.331 3.276   -16.331  0.46 39.486  ? 701  A3P A C8    1 ? 
HETATM 9365  C  C8    B A3P C 2 .   ? -19.77  3.723   -16.082  0.54 28.166  ? 701  A3P A C8    1 ? 
HETATM 9366  N  N7    A A3P C 2 .   ? -20.64  3.263   -16.213  0.46 39.782  ? 701  A3P A N7    1 ? 
HETATM 9367  N  N7    B A3P C 2 .   ? -21.059 3.831   -15.841  0.54 27.137  ? 701  A3P A N7    1 ? 
HETATM 9368  C  C5    A A3P C 2 .   ? -21.017 1.979   -16.587  0.46 41.397  ? 701  A3P A C5    1 ? 
HETATM 9369  C  C5    B A3P C 2 .   ? -21.562 2.551   -16.039  0.54 28.26   ? 701  A3P A C5    1 ? 
HETATM 9370  C  C6    A A3P C 2 .   ? -22.271 1.337   -16.667  0.46 43.164  ? 701  A3P A C6    1 ? 
HETATM 9371  C  C6    B A3P C 2 .   ? -22.857 2.003   -15.915  0.54 27.848  ? 701  A3P A C6    1 ? 
HETATM 9372  N  N6    A A3P C 2 .   ? -23.429 1.916   -16.365  0.46 44.138  ? 701  A3P A N6    1 ? 
HETATM 9373  N  N6    B A3P C 2 .   ? -23.92  2.715   -15.557  0.54 28.319  ? 701  A3P A N6    1 ? 
HETATM 9374  N  N1    A A3P C 2 .   ? -22.286 0.046   -17.074  0.46 44.383  ? 701  A3P A N1    1 ? 
HETATM 9375  N  N1    B A3P C 2 .   ? -23.011 0.684   -16.177  0.54 24.292  ? 701  A3P A N1    1 ? 
HETATM 9376  C  C2    A A3P C 2 .   ? -21.121 -0.54   -17.389  0.46 47.392  ? 701  A3P A C2    1 ? 
HETATM 9377  C  C2    B A3P C 2 .   ? -21.928 -0.03   -16.503  0.54 26.089  ? 701  A3P A C2    1 ? 
HETATM 9378  N  N3    A A3P C 2 .   ? -19.886 -0.042  -17.351  0.46 45.651  ? 701  A3P A N3    1 ? 
HETATM 9379  N  N3    B A3P C 2 .   ? -20.662 0.372   -16.63   0.54 29.573  ? 701  A3P A N3    1 ? 
HETATM 9380  C  C4    A A3P C 2 .   ? -19.904 1.238   -16.935  0.46 43.636  ? 701  A3P A C4    1 ? 
HETATM 9381  C  C4    B A3P C 2 .   ? -20.545 1.687   -16.374  0.54 28.002  ? 701  A3P A C4    1 ? 
HETATM 9382  MG MG    . MG  D 3 .   ? -12.4   5.261   -18.206  1    40.044  ? 702  MG  A MG    1 ? 
HETATM 9383  MG MG    . MG  E 3 .   ? -12.997 7.291   -21.684  1    56.118  ? 703  MG  A MG    1 ? 
HETATM 9384  C  C1    . EDO F 4 .   ? -19.903 14.168  -24.9    1    63.803  ? 704  EDO A C1    1 ? 
HETATM 9385  O  O1    . EDO F 4 .   ? -20.001 13.77   -26.256  1    68.767  ? 704  EDO A O1    1 ? 
HETATM 9386  C  C2    . EDO F 4 .   ? -19.304 15.527  -24.837  1    59.576  ? 704  EDO A C2    1 ? 
HETATM 9387  O  O2    . EDO F 4 .   ? -19.078 15.952  -23.506  1    40.197  ? 704  EDO A O2    1 ? 
HETATM 9388  C  C1    . EDO G 4 .   ? -16.896 1.045   -26.91   1    60.808  ? 705  EDO A C1    1 ? 
HETATM 9389  O  O1    . EDO G 4 .   ? -16.682 0.838   -28.317  1    39.401  ? 705  EDO A O1    1 ? 
HETATM 9390  C  C2    . EDO G 4 .   ? -18.243 1.445   -26.396  1    69.293  ? 705  EDO A C2    1 ? 
HETATM 9391  O  O2    . EDO G 4 .   ? -19.011 0.37    -25.865  1    66.506  ? 705  EDO A O2    1 ? 
HETATM 9392  C  C1    . EDO H 4 .   ? -18.404 -2.639  -42.537  1    75.31   ? 706  EDO A C1    1 ? 
HETATM 9393  O  O1    . EDO H 4 .   ? -18.772 -1.832  -43.653  1    82.51   ? 706  EDO A O1    1 ? 
HETATM 9394  C  C2    . EDO H 4 .   ? -19.514 -3.215  -41.726  1    61.334  ? 706  EDO A C2    1 ? 
HETATM 9395  O  O2    . EDO H 4 .   ? -20.792 -2.641  -41.928  1    63.98   ? 706  EDO A O2    1 ? 
HETATM 9396  C  C1    . EDO I 4 .   ? -31.921 -2.71   -8.05    1    35.107  ? 707  EDO A C1    1 ? 
HETATM 9397  O  O1    . EDO I 4 .   ? -31.314 -3.271  -9.244   1    34.327  ? 707  EDO A O1    1 ? 
HETATM 9398  C  C2    . EDO I 4 .   ? -31.696 -1.25   -7.916   1    39.469  ? 707  EDO A C2    1 ? 
HETATM 9399  O  O2    . EDO I 4 .   ? -31.164 -0.624  -9.086   1    39.253  ? 707  EDO A O2    1 ? 
HETATM 9400  C  C1    . EDO J 4 .   ? -0.375  -3.045  0.668    1    45.664  ? 708  EDO A C1    1 ? 
HETATM 9401  O  O1    . EDO J 4 .   ? -1.783  -2.89   0.932    1    41.842  ? 708  EDO A O1    1 ? 
HETATM 9402  C  C2    . EDO J 4 .   ? 0.027   -3.589  -0.644   1    36.791  ? 708  EDO A C2    1 ? 
HETATM 9403  O  O2    . EDO J 4 .   ? 1.205   -4.353  -0.552   1    44.393  ? 708  EDO A O2    1 ? 
HETATM 9404  C  C1    . EDO K 4 .   ? -0.594  8.786   -12.498  1    48.295  ? 709  EDO A C1    1 ? 
HETATM 9405  O  O1    . EDO K 4 .   ? 0.795   8.759   -12.632  1    44.587  ? 709  EDO A O1    1 ? 
HETATM 9406  C  C2    . EDO K 4 .   ? -0.899  9.865   -11.537  1    44.874  ? 709  EDO A C2    1 ? 
HETATM 9407  O  O2    . EDO K 4 .   ? -2.256  10.19   -11.598  1    38.665  ? 709  EDO A O2    1 ? 
HETATM 9408  C  C1    . EDO L 4 .   ? 3.498   6.969   -12.153  1    28.01   ? 710  EDO A C1    1 ? 
HETATM 9409  O  O1    . EDO L 4 .   ? 3.4     8.074   -13.082  1    25.81   ? 710  EDO A O1    1 ? 
HETATM 9410  C  C2    . EDO L 4 .   ? 2.221   6.134   -12.074  1    28.241  ? 710  EDO A C2    1 ? 
HETATM 9411  O  O2    . EDO L 4 .   ? 1.179   6.69    -11.244  1    29.127  ? 710  EDO A O2    1 ? 
HETATM 9412  C  C1    . EDO M 4 .   ? -38.098 17.254  -50.079  1    71.822  ? 711  EDO A C1    1 ? 
HETATM 9413  O  O1    . EDO M 4 .   ? -38.585 15.97   -50.434  1    62.598  ? 711  EDO A O1    1 ? 
HETATM 9414  C  C2    . EDO M 4 .   ? -37.724 18.098  -51.237  1    73.181  ? 711  EDO A C2    1 ? 
HETATM 9415  O  O2    . EDO M 4 .   ? -38.678 19.111  -51.509  1    76.889  ? 711  EDO A O2    1 ? 
HETATM 9416  C  C1    . EDO N 4 .   ? -34.903 22.91   -44.969  1    66.43   ? 712  EDO A C1    1 ? 
HETATM 9417  O  O1    . EDO N 4 .   ? -35.447 21.651  -45.343  1    69.867  ? 712  EDO A O1    1 ? 
HETATM 9418  C  C2    . EDO N 4 .   ? -35.352 23.412  -43.64   1    65.517  ? 712  EDO A C2    1 ? 
HETATM 9419  O  O2    . EDO N 4 .   ? -34.91  22.657  -42.524  1    61.734  ? 712  EDO A O2    1 ? 
HETATM 9420  C  C1    . EDO O 4 .   ? -15.058 25.545  7.185    1    46.753  ? 713  EDO A C1    1 ? 
HETATM 9421  O  O1    . EDO O 4 .   ? -15.389 26.628  8.07     1    40.815  ? 713  EDO A O1    1 ? 
HETATM 9422  C  C2    . EDO O 4 .   ? -15.602 25.495  5.79     1    37.572  ? 713  EDO A C2    1 ? 
HETATM 9423  O  O2    . EDO O 4 .   ? -14.604 25.619  4.744    1    37.809  ? 713  EDO A O2    1 ? 
HETATM 9424  C  C1    . EDO P 4 .   ? 0.131   -19.862 7.074    1    50.193  ? 714  EDO A C1    1 ? 
HETATM 9425  O  O1    . EDO P 4 .   ? -0.705  -19.741 5.932    1    41.228  ? 714  EDO A O1    1 ? 
HETATM 9426  C  C2    . EDO P 4 .   ? -0.504  -19.943 8.441    1    46.941  ? 714  EDO A C2    1 ? 
HETATM 9427  O  O2    . EDO P 4 .   ? 0.464   -19.774 9.498    1    52.159  ? 714  EDO A O2    1 ? 
HETATM 9428  C  C1    . EDO Q 4 .   ? 7.866   0.941   0.478    1    30.347  ? 715  EDO A C1    1 ? 
HETATM 9429  O  O1    . EDO Q 4 .   ? 9.266   0.997   0.486    1    36.826  ? 715  EDO A O1    1 ? 
HETATM 9430  C  C2    . EDO Q 4 .   ? 7.432   2.119   -0.28    1    29.818  ? 715  EDO A C2    1 ? 
HETATM 9431  O  O2    . EDO Q 4 .   ? 7.913   2.217   -1.614   1    20.95   ? 715  EDO A O2    1 ? 
HETATM 9432  C  C1    . EDO R 4 .   ? -36.508 -6.106  2.474    1    75.328  ? 716  EDO A C1    1 ? 
HETATM 9433  O  O1    . EDO R 4 .   ? -37.162 -6.962  1.533    1    59.25   ? 716  EDO A O1    1 ? 
HETATM 9434  C  C2    . EDO R 4 .   ? -37.297 -5.714  3.677    1    70.407  ? 716  EDO A C2    1 ? 
HETATM 9435  O  O2    . EDO R 4 .   ? -37.445 -4.314  3.811    1    67.879  ? 716  EDO A O2    1 ? 
HETATM 9436  C  C1    . EDO S 4 .   ? -12.622 25.408  -23.016  1    59.379  ? 717  EDO A C1    1 ? 
HETATM 9437  O  O1    . EDO S 4 .   ? -13.99  25.089  -23.233  1    56.857  ? 717  EDO A O1    1 ? 
HETATM 9438  C  C2    . EDO S 4 .   ? -11.951 24.684  -21.912  1    40.93   ? 717  EDO A C2    1 ? 
HETATM 9439  O  O2    . EDO S 4 .   ? -12.195 25.138  -20.582  1    58.423  ? 717  EDO A O2    1 ? 
HETATM 9440  CL CL    . CL  T 5 .   ? 8.237   -3.763  1.083    1    57.212  ? 718  CL  A CL    1 ? 
HETATM 9441  C  C1    . PEG U 6 .   ? 8.633   -2.11   5.297    1    54.919  ? 719  PEG A C1    1 ? 
HETATM 9442  O  O1    . PEG U 6 .   ? 7.849   -2.18   6.496    1    51.75   ? 719  PEG A O1    1 ? 
HETATM 9443  C  C2    . PEG U 6 .   ? 8.848   -3.462  4.667    1    61.713  ? 719  PEG A C2    1 ? 
HETATM 9444  O  O2    . PEG U 6 .   ? 9.266   -4.412  5.651    1    68.656  ? 719  PEG A O2    1 ? 
HETATM 9445  C  C3    . PEG U 6 .   ? 8.543   -5.64   5.61     1    70.074  ? 719  PEG A C3    1 ? 
HETATM 9446  C  C4    . PEG U 6 .   ? 9.165   -6.634  6.554    1    70.693  ? 719  PEG A C4    1 ? 
HETATM 9447  O  O4    . PEG U 6 .   ? 8.195   -7.376  7.269    1    56.668  ? 719  PEG A O4    1 ? 
HETATM 9448  C  C1    . EDO V 4 .   ? -35.42  -9.895  -77.956  1    54.058  ? 701  EDO B C1    1 ? 
HETATM 9449  O  O1    . EDO V 4 .   ? -36.692 -10.513 -77.902  1    63.006  ? 701  EDO B O1    1 ? 
HETATM 9450  C  C2    . EDO V 4 .   ? -35.605 -8.488  -77.549  1    61.076  ? 701  EDO B C2    1 ? 
HETATM 9451  O  O2    . EDO V 4 .   ? -34.447 -7.871  -77.036  1    67.6    ? 701  EDO B O2    1 ? 
HETATM 9452  C  C1    . EDO W 4 .   ? -22.099 -20.782 -79.567  1    51.707  ? 702  EDO B C1    1 ? 
HETATM 9453  O  O1    . EDO W 4 .   ? -21.596 -20.213 -80.742  1    57.008  ? 702  EDO B O1    1 ? 
HETATM 9454  C  C2    . EDO W 4 .   ? -22.52  -22.2   -79.708  1    47.237  ? 702  EDO B C2    1 ? 
HETATM 9455  O  O2    . EDO W 4 .   ? -23.758 -22.421 -79.047  1    45.558  ? 702  EDO B O2    1 ? 
HETATM 9456  O  O     . HOH X 7 .   ? -12.743 1.567   -22.168  1    48.308  ? 801  HOH A O     1 ? 
HETATM 9457  O  O     . HOH X 7 .   ? -13.75  5.433   -22.386  1    64.708  ? 802  HOH A O     1 ? 
HETATM 9458  O  O     . HOH X 7 .   ? 1.629   -5.529  1.323    1    36.195  ? 803  HOH A O     1 ? 
HETATM 9459  O  O     . HOH X 7 .   ? 1.081   7.132   -25.558  1    36.024  ? 804  HOH A O     1 ? 
HETATM 9460  O  O     . HOH X 7 .   ? -37.345 9.757   -12.959  1    28.214  ? 805  HOH A O     1 ? 
HETATM 9461  O  O     . HOH X 7 .   ? 2.124   13.518  -12.564  1    43.693  ? 806  HOH A O     1 ? 
HETATM 9462  O  O     . HOH X 7 .   ? -17.446 2.575   4.544    1    57.825  ? 807  HOH A O     1 ? 
HETATM 9463  O  O     . HOH X 7 .   ? -26.347 28.643  -10.198  1    34.37   ? 808  HOH A O     1 ? 
HETATM 9464  O  O     . HOH X 7 .   ? -3.999  4.642   -3.349   1    33.343  ? 809  HOH A O     1 ? 
HETATM 9465  O  O     . HOH X 7 .   ? -17.532 4.339   -12.832  1    20.565  ? 810  HOH A O     1 ? 
HETATM 9466  O  O     . HOH X 7 .   ? 8.807   10.499  -16.643  1    55.24   ? 811  HOH A O     1 ? 
HETATM 9467  O  O     . HOH X 7 .   ? -9.699  29.741  2.239    1    30.624  ? 812  HOH A O     1 ? 
HETATM 9468  O  O     . HOH X 7 .   ? -26.422 5.084   -45.55   1    54.774  ? 813  HOH A O     1 ? 
HETATM 9469  O  O     . HOH X 7 .   ? -16.35  -7.251  -18.647  1    51.134  ? 814  HOH A O     1 ? 
HETATM 9470  O  O     . HOH X 7 .   ? -10.543 8.433   10.082   1    42.574  ? 815  HOH A O     1 ? 
HETATM 9471  O  O     . HOH X 7 .   ? 7.181   -17.934 0.882    1    52.172  ? 816  HOH A O     1 ? 
HETATM 9472  O  O     . HOH X 7 .   ? -1.196  4.195   -3.034   1    41.55   ? 817  HOH A O     1 ? 
HETATM 9473  O  O     . HOH X 7 .   ? -38.865 3.242   -16.46   1    46.991  ? 818  HOH A O     1 ? 
HETATM 9474  O  O     . HOH X 7 .   ? -26.962 7.626   -3.167   1    22.77   ? 819  HOH A O     1 ? 
HETATM 9475  O  O     . HOH X 7 .   ? -24.476 16.089  -42.409  1    43.894  ? 820  HOH A O     1 ? 
HETATM 9476  O  O     . HOH X 7 .   ? 8.753   -4.484  -17.012  1    42.548  ? 821  HOH A O     1 ? 
HETATM 9477  O  O     . HOH X 7 .   ? -22.785 -9.688  -8.649   1    25.392  ? 822  HOH A O     1 ? 
HETATM 9478  O  O     . HOH X 7 .   ? 4.866   7.487   -19.644  1    29.758  ? 823  HOH A O     1 ? 
HETATM 9479  O  O     . HOH X 7 .   ? -18.058 1.425   -30.297  1    54.29   ? 824  HOH A O     1 ? 
HETATM 9480  O  O     . HOH X 7 .   ? 7.433   -4.08   -14.614  1    33.87   ? 825  HOH A O     1 ? 
HETATM 9481  O  O     . HOH X 7 .   ? -25.142 -0.483  -16.718  1    52.63   ? 826  HOH A O     1 ? 
HETATM 9482  O  O     . HOH X 7 .   ? -23.691 16.316  -23.739  1    23.796  ? 827  HOH A O     1 ? 
HETATM 9483  O  O     . HOH X 7 .   ? 8.626   -6.517  -13.689  1    43.856  ? 828  HOH A O     1 ? 
HETATM 9484  O  O     . HOH X 7 .   ? -1.147  27.777  -36.203  1    50.389  ? 829  HOH A O     1 ? 
HETATM 9485  O  O     . HOH X 7 .   ? 3.5     8.967   -28.289  1    45.414  ? 830  HOH A O     1 ? 
HETATM 9486  O  O     . HOH X 7 .   ? 1.707   -17.482 2.513    1    26.146  ? 831  HOH A O     1 ? 
HETATM 9487  O  O     . HOH X 7 .   ? -14.135 -11.949 -31.991  1    48.735  ? 832  HOH A O     1 ? 
HETATM 9488  O  O     . HOH X 7 .   ? -2.762  8.347   -22.921  1    34.638  ? 833  HOH A O     1 ? 
HETATM 9489  O  O     . HOH X 7 .   ? -21.724 36.477  -33.434  1    44.433  ? 834  HOH A O     1 ? 
HETATM 9490  O  O     . HOH X 7 .   ? -31.761 29.61   0.627    1    20.873  ? 835  HOH A O     1 ? 
HETATM 9491  O  O     . HOH X 7 .   ? -14.94  7.195   -12.452  1    28.265  ? 836  HOH A O     1 ? 
HETATM 9492  O  O     . HOH X 7 .   ? -6.108  -3.965  2.579    1    18.51   ? 837  HOH A O     1 ? 
HETATM 9493  O  O     . HOH X 7 .   ? -21.37  17.337  -40.719  1    32.671  ? 838  HOH A O     1 ? 
HETATM 9494  O  O     . HOH X 7 .   ? -9.074  3.324   1.66     1    47.109  ? 839  HOH A O     1 ? 
HETATM 9495  O  O     . HOH X 7 .   ? -20.097 22.475  -31.157  1    24.739  ? 840  HOH A O     1 ? 
HETATM 9496  O  O     . HOH X 7 .   ? 8.903   4.558   -1.564   1    24.092  ? 841  HOH A O     1 ? 
HETATM 9497  O  O     . HOH X 7 .   ? 5.021   -5.919  -28.705  1    36.827  ? 842  HOH A O     1 ? 
HETATM 9498  O  O     . HOH X 7 .   ? -5.567  23.236  -17.192  1    24.793  ? 843  HOH A O     1 ? 
HETATM 9499  O  O     . HOH X 7 .   ? -21.386 3.048   2.126    1    48.195  ? 844  HOH A O     1 ? 
HETATM 9500  O  O     . HOH X 7 .   ? -0.254  9.239   -0.729   1    19.57   ? 845  HOH A O     1 ? 
HETATM 9501  O  O     . HOH X 7 .   ? -5.415  5.018   0.601    1    33.002  ? 846  HOH A O     1 ? 
HETATM 9502  O  O     . HOH X 7 .   ? -18.984 16.718  6.393    1    25.886  ? 847  HOH A O     1 ? 
HETATM 9503  O  O     . HOH X 7 .   ? 1.087   24.217  -18.676  1    43.389  ? 848  HOH A O     1 ? 
HETATM 9504  O  O     . HOH X 7 .   ? -11.916 29.596  -36.688  1    45.1    ? 849  HOH A O     1 ? 
HETATM 9505  O  O     . HOH X 7 .   ? 7.455   -16.136 2.891    1    64.549  ? 850  HOH A O     1 ? 
HETATM 9506  O  O     . HOH X 7 .   ? 0.837   19.692  -47.085  1    43.955  ? 851  HOH A O     1 ? 
HETATM 9507  O  O     . HOH X 7 .   ? -20.688 -11.605 9.164    1    45.261  ? 852  HOH A O     1 ? 
HETATM 9508  O  O     . HOH X 7 .   ? 12.191  -9.362  -3.878   1    32.31   ? 853  HOH A O     1 ? 
HETATM 9509  O  O     . HOH X 7 .   ? -22.227 18.951  -18.05   1    22.454  ? 854  HOH A O     1 ? 
HETATM 9510  O  O     . HOH X 7 .   ? -7.148  10.293  -17.618  1    21.499  ? 855  HOH A O     1 ? 
HETATM 9511  O  O     . HOH X 7 .   ? 1.534   6.795   -8.693   1    15.672  ? 856  HOH A O     1 ? 
HETATM 9512  O  O     . HOH X 7 .   ? 3.984   9.207   -21.171  1    37.515  ? 857  HOH A O     1 ? 
HETATM 9513  O  O     . HOH X 7 .   ? -28.891 19.568  1.311    1    33.215  ? 858  HOH A O     1 ? 
HETATM 9514  O  O     . HOH X 7 .   ? -31.344 14.116  -2.739   1    32.482  ? 859  HOH A O     1 ? 
HETATM 9515  O  O     . HOH X 7 .   ? -8.402  22.097  -3.588   1    39.223  ? 860  HOH A O     1 ? 
HETATM 9516  O  O     . HOH X 7 .   ? -24.147 -2.96   -1.058   1    25.943  ? 861  HOH A O     1 ? 
HETATM 9517  O  O     . HOH X 7 .   ? -14.947 22.025  -43.639  1    41.085  ? 862  HOH A O     1 ? 
HETATM 9518  O  O     . HOH X 7 .   ? 7.744   1.185   -16.014  1    25.875  ? 863  HOH A O     1 ? 
HETATM 9519  O  O     . HOH X 7 .   ? -5.105  -18.799 -10.328  1    38.78   ? 864  HOH A O     1 ? 
HETATM 9520  O  O     . HOH X 7 .   ? 5.107   -18.876 -10.668  1    37.018  ? 865  HOH A O     1 ? 
HETATM 9521  O  O     . HOH X 7 .   ? -16.221 14.278  -33.727  1    44.708  ? 866  HOH A O     1 ? 
HETATM 9522  O  O     . HOH X 7 .   ? -23.143 -9.48   4.43     1    49.427  ? 867  HOH A O     1 ? 
HETATM 9523  O  O     . HOH X 7 .   ? 3.293   -14.185 9.696    1    39.116  ? 868  HOH A O     1 ? 
HETATM 9524  O  O     . HOH X 7 .   ? 1.895   -18.13  10.9     1    47.26   ? 869  HOH A O     1 ? 
HETATM 9525  O  O     . HOH X 7 .   ? 6.684   8.208   -53.103  1    62.956  ? 870  HOH A O     1 ? 
HETATM 9526  O  O     . HOH X 7 .   ? -29.745 3.197   -15.563  1    41.905  ? 871  HOH A O     1 ? 
HETATM 9527  O  O     . HOH X 7 .   ? -0.492  21.521  -29.052  1    46.61   ? 872  HOH A O     1 ? 
HETATM 9528  O  O     . HOH X 7 .   ? -34.623 -7.892  -2.45    1    26.192  ? 873  HOH A O     1 ? 
HETATM 9529  O  O     . HOH X 7 .   ? -12.249 29.365  -8.015   1    37.222  ? 874  HOH A O     1 ? 
HETATM 9530  O  O     . HOH X 7 .   ? 3.589   10.818  -5.258   1    21.777  ? 875  HOH A O     1 ? 
HETATM 9531  O  O     . HOH X 7 .   ? -13.406 7.689   -15.435  1    32.711  ? 876  HOH A O     1 ? 
HETATM 9532  O  O     . HOH X 7 .   ? -15.117 -4.383  10.504   1    54.028  ? 877  HOH A O     1 ? 
HETATM 9533  O  O     . HOH X 7 .   ? -38.538 16.023  -20.401  1    52.981  ? 878  HOH A O     1 ? 
HETATM 9534  O  O     . HOH X 7 .   ? -4.558  18.377  -7.55    1    32.033  ? 879  HOH A O     1 ? 
HETATM 9535  O  O     . HOH X 7 .   ? -2.176  -17.123 -21.994  1    45.174  ? 880  HOH A O     1 ? 
HETATM 9536  O  O     . HOH X 7 .   ? 1.664   10.477  -18.508  1    35.573  ? 881  HOH A O     1 ? 
HETATM 9537  O  O     . HOH X 7 .   ? 0.485   21.783  -13.492  1    39.236  ? 882  HOH A O     1 ? 
HETATM 9538  O  O     . HOH X 7 .   ? -20.966 5.951   -14.33   1    34.044  ? 883  HOH A O     1 ? 
HETATM 9539  O  O     . HOH X 7 .   ? 1.294   10.328  -39.326  1    41.191  ? 884  HOH A O     1 ? 
HETATM 9540  O  O     . HOH X 7 .   ? -11.94  -1.767  -49.069  1    59.235  ? 885  HOH A O     1 ? 
HETATM 9541  O  O     . HOH X 7 .   ? -23.888 5.476   -12.081  1    31.309  ? 886  HOH A O     1 ? 
HETATM 9542  O  O     . HOH X 7 .   ? -20.296 11.835  -49.301  1    54.585  ? 887  HOH A O     1 ? 
HETATM 9543  O  O     . HOH X 7 .   ? -19.131 -12.633 1.827    1    60.447  ? 888  HOH A O     1 ? 
HETATM 9544  O  O     . HOH X 7 .   ? -14.003 8       -31.929  1    48.019  ? 889  HOH A O     1 ? 
HETATM 9545  O  O     . HOH X 7 .   ? -45.381 5.98    -14.751  1    53.958  ? 890  HOH A O     1 ? 
HETATM 9546  O  O     . HOH X 7 .   ? -0.695  24.503  -15.551  1    37.942  ? 891  HOH A O     1 ? 
HETATM 9547  O  O     . HOH X 7 .   ? -39.421 -6.67   -2.493   1    35.919  ? 892  HOH A O     1 ? 
HETATM 9548  O  O     . HOH X 7 .   ? -3.648  14.621  -2.411   1    32.434  ? 893  HOH A O     1 ? 
HETATM 9549  O  O     . HOH X 7 .   ? 8.181   -12.829 -7.244   1    30.39   ? 894  HOH A O     1 ? 
HETATM 9550  O  O     . HOH X 7 .   ? -17.822 -5.376  -24.003  1    38.643  ? 895  HOH A O     1 ? 
HETATM 9551  O  O     . HOH X 7 .   ? -1.783  8.459   -20.466  1    35.264  ? 896  HOH A O     1 ? 
HETATM 9552  O  O     . HOH X 7 .   ? 0.655   16.391  -14.039  1    42.158  ? 897  HOH A O     1 ? 
HETATM 9553  O  O     . HOH X 7 .   ? -32.912 -9.863  -10.216  1    43.387  ? 898  HOH A O     1 ? 
HETATM 9554  O  O     . HOH X 7 .   ? -19.372 28.842  -31.117  1    49.592  ? 899  HOH A O     1 ? 
HETATM 9555  O  O     . HOH X 7 .   ? -20.724 13.684  6.35     1    31.538  ? 900  HOH A O     1 ? 
HETATM 9556  O  O     . HOH X 7 .   ? -9.842  16.505  -12.638  1    15.415  ? 901  HOH A O     1 ? 
HETATM 9557  O  O     . HOH X 7 .   ? 1.358   11.185  -14.358  1    55.073  ? 902  HOH A O     1 ? 
HETATM 9558  O  O     . HOH X 7 .   ? -24.402 21.076  3.806    1    22.72   ? 903  HOH A O     1 ? 
HETATM 9559  O  O     . HOH X 7 .   ? -14.863 -2.879  5.584    1    48.59   ? 904  HOH A O     1 ? 
HETATM 9560  O  O     . HOH X 7 .   ? -10.145 4.734   -37.672  1    37.581  ? 905  HOH A O     1 ? 
HETATM 9561  O  O     . HOH X 7 .   ? -1.541  12.739  -11.432  1    40.863  ? 906  HOH A O     1 ? 
HETATM 9562  O  O     . HOH X 7 .   ? -0.094  24.324  -25.498  1    47.885  ? 907  HOH A O     1 ? 
HETATM 9563  O  O     . HOH X 7 .   ? -14.17  -21.118 -31.383  1    59.422  ? 908  HOH A O     1 ? 
HETATM 9564  O  O     . HOH X 7 .   ? 9.619   14.696  -18.659  1    57.599  ? 909  HOH A O     1 ? 
HETATM 9565  O  O     . HOH X 7 .   ? -5.361  10.586  3.294    1    39.134  ? 910  HOH A O     1 ? 
HETATM 9566  O  O     . HOH X 7 .   ? -13.652 -3.789  -16.435  1    33.722  ? 911  HOH A O     1 ? 
HETATM 9567  O  O     . HOH X 7 .   ? -32.858 24.334  -5.089   1    34.857  ? 912  HOH A O     1 ? 
HETATM 9568  O  O     . HOH X 7 .   ? -46.493 -0.036  -2.99    1    26.038  ? 913  HOH A O     1 ? 
HETATM 9569  O  O     . HOH X 7 .   ? 6.763   -4.441  -20.383  1    36.906  ? 914  HOH A O     1 ? 
HETATM 9570  O  O     B HOH X 7 .   ? -13.153 4.803   -20.112  0.54 31.907  ? 915  HOH A O     1 ? 
HETATM 9571  O  O     . HOH X 7 .   ? 11.007  3.928   -17.867  1    44.651  ? 916  HOH A O     1 ? 
HETATM 9572  O  O     . HOH X 7 .   ? -30.107 3.541   -13.079  1    28.045  ? 917  HOH A O     1 ? 
HETATM 9573  O  O     . HOH X 7 .   ? 10.134  -2.875  -20.765  1    48.081  ? 918  HOH A O     1 ? 
HETATM 9574  O  O     . HOH X 7 .   ? -3.016  6.331   0.89     1    28.475  ? 919  HOH A O     1 ? 
HETATM 9575  O  O     . HOH X 7 .   ? -28.7   10.734  -1.913   1    29.204  ? 920  HOH A O     1 ? 
HETATM 9576  O  O     . HOH X 7 .   ? -14.604 11.762  -7.674   1    18.004  ? 921  HOH A O     1 ? 
HETATM 9577  O  O     . HOH X 7 .   ? 0.119   11.793  -3       1    40.716  ? 922  HOH A O     1 ? 
HETATM 9578  O  O     . HOH X 7 .   ? -9.396  18.196  -19.556  1    14.505  ? 923  HOH A O     1 ? 
HETATM 9579  O  O     B HOH X 7 .   ? -34.436 13.275  -19.152  0.5  17.788  ? 924  HOH A O     1 ? 
HETATM 9580  O  O     . HOH X 7 .   ? 2.706   9.926   -37.148  1    34.389  ? 925  HOH A O     1 ? 
HETATM 9581  O  O     . HOH X 7 .   ? 4.454   13.738  -22.949  1    50.579  ? 926  HOH A O     1 ? 
HETATM 9582  O  O     . HOH X 7 .   ? -38.478 -4.409  -11.36   1    38.38   ? 927  HOH A O     1 ? 
HETATM 9583  O  O     . HOH X 7 .   ? -17.601 -17.174 -23.403  1    54.835  ? 928  HOH A O     1 ? 
HETATM 9584  O  O     . HOH X 7 .   ? -18.627 11.053  3.999    1    22.948  ? 929  HOH A O     1 ? 
HETATM 9585  O  O     . HOH X 7 .   ? 0.251   14.573  -18.373  1    29.08   ? 930  HOH A O     1 ? 
HETATM 9586  O  O     . HOH X 7 .   ? -2.112  11.822  -0.245   1    42.816  ? 931  HOH A O     1 ? 
HETATM 9587  O  O     . HOH X 7 .   ? -8.002  21.23   -7.044   1    29.62   ? 932  HOH A O     1 ? 
HETATM 9588  O  O     . HOH X 7 .   ? -0.949  4.907   -12.214  1    17.69   ? 933  HOH A O     1 ? 
HETATM 9589  O  O     . HOH X 7 .   ? -40.672 -4.127  1.817    1    44.701  ? 934  HOH A O     1 ? 
HETATM 9590  O  O     . HOH X 7 .   ? -28.232 3.454   -9.705   1    54.467  ? 935  HOH A O     1 ? 
HETATM 9591  O  O     . HOH X 7 .   ? -3.046  -23.637 -24.056  1    49.626  ? 936  HOH A O     1 ? 
HETATM 9592  O  O     . HOH X 7 .   ? 4.686   -12.028 -7.78    1    20.86   ? 937  HOH A O     1 ? 
HETATM 9593  O  O     . HOH X 7 .   ? -21.162 28.083  -15.776  1    38.426  ? 938  HOH A O     1 ? 
HETATM 9594  O  O     . HOH X 7 .   ? 8.088   5.853   -24.426  1    42.51   ? 939  HOH A O     1 ? 
HETATM 9595  O  O     . HOH X 7 .   ? -32.58  20.154  -19.828  1    31.54   ? 940  HOH A O     1 ? 
HETATM 9596  O  O     . HOH X 7 .   ? -23.535 -11.31  1.966    1    31.874  ? 941  HOH A O     1 ? 
HETATM 9597  O  O     . HOH X 7 .   ? -32.794 0.257   -11.047  1    31.56   ? 942  HOH A O     1 ? 
HETATM 9598  O  O     . HOH X 7 .   ? -2.414  -21.653 -9.656   1    43.915  ? 943  HOH A O     1 ? 
HETATM 9599  O  O     . HOH X 7 .   ? -22.785 -0.022  -0.423   1    30.531  ? 944  HOH A O     1 ? 
HETATM 9600  O  O     . HOH X 7 .   ? -4.059  2.637   -0.469   1    25.165  ? 945  HOH A O     1 ? 
HETATM 9601  O  O     . HOH X 7 .   ? -16.542 24.469  10.321   1    35.907  ? 946  HOH A O     1 ? 
HETATM 9602  O  O     . HOH X 7 .   ? -0.648  18.403  -12.827  1    39.994  ? 947  HOH A O     1 ? 
HETATM 9603  O  O     . HOH X 7 .   ? -4.026  -16.617 6.668    1    39.568  ? 948  HOH A O     1 ? 
HETATM 9604  O  O     . HOH X 7 .   ? -34.815 21.087  -13.183  1    31.789  ? 949  HOH A O     1 ? 
HETATM 9605  O  O     . HOH X 7 .   ? -3.146  2.141   -6.072   1    20.353  ? 950  HOH A O     1 ? 
HETATM 9606  O  O     . HOH X 7 .   ? -35.26  12.368  -27.741  1    50.006  ? 951  HOH A O     1 ? 
HETATM 9607  O  O     . HOH X 7 .   ? 7.979   -18.595 9.317    1    45.939  ? 952  HOH A O     1 ? 
HETATM 9608  O  O     . HOH X 7 .   ? -12.8   22.941  -16.592  1    25.546  ? 953  HOH A O     1 ? 
HETATM 9609  O  O     . HOH X 7 .   ? -9.206  4.772   -0.771   1    22.212  ? 954  HOH A O     1 ? 
HETATM 9610  O  O     . HOH X 7 .   ? -40.899 -0.088  0.724    1    34.719  ? 955  HOH A O     1 ? 
HETATM 9611  O  O     . HOH X 7 .   ? -7.68   25.263  -14.263  1    47.79   ? 956  HOH A O     1 ? 
HETATM 9612  O  O     . HOH X 7 .   ? 7.237   -7.28   -19.844  1    26.962  ? 957  HOH A O     1 ? 
HETATM 9613  O  O     . HOH X 7 .   ? -13.119 9.295   -12.853  1    18.889  ? 958  HOH A O     1 ? 
HETATM 9614  O  O     . HOH X 7 .   ? 9.306   4.689   -4.35    1    25.141  ? 959  HOH A O     1 ? 
HETATM 9615  O  O     . HOH X 7 .   ? -42.077 -2.91   -12.655  1    47.217  ? 960  HOH A O     1 ? 
HETATM 9616  O  O     . HOH X 7 .   ? -12.957 -10.593 -38.108  1    49.333  ? 961  HOH A O     1 ? 
HETATM 9617  O  O     . HOH X 7 .   ? -28.337 6.056   -9.399   1    35.016  ? 962  HOH A O     1 ? 
HETATM 9618  O  O     . HOH X 7 .   ? -20.948 31.005  -8.596   1    33.659  ? 963  HOH A O     1 ? 
HETATM 9619  O  O     . HOH X 7 .   ? -28.732 10.349  -29.73   1    51.886  ? 964  HOH A O     1 ? 
HETATM 9620  O  O     . HOH X 7 .   ? 5.534   15.573  -35.135  1    47.297  ? 965  HOH A O     1 ? 
HETATM 9621  O  O     . HOH X 7 .   ? 10.183  5.088   -9.264   1    36.583  ? 966  HOH A O     1 ? 
HETATM 9622  O  O     . HOH X 7 .   ? -5.437  -18.166 -3.761   1    34.605  ? 967  HOH A O     1 ? 
HETATM 9623  O  O     . HOH X 7 .   ? -16.445 1.668   -22.046  1    62.913  ? 968  HOH A O     1 ? 
HETATM 9624  O  O     . HOH X 7 .   ? -30.82  20.518  -7.064   1    18.054  ? 969  HOH A O     1 ? 
HETATM 9625  O  O     . HOH X 7 .   ? -18     27.173  7.501    1    21.947  ? 970  HOH A O     1 ? 
HETATM 9626  O  O     . HOH X 7 .   ? 6.798   -19.355 -6.27    1    32.228  ? 971  HOH A O     1 ? 
HETATM 9627  O  O     . HOH X 7 .   ? -28.344 -0.781  -8.314   1    38.38   ? 972  HOH A O     1 ? 
HETATM 9628  O  O     . HOH X 7 .   ? -40.193 -1.155  -12.651  1    25.429  ? 973  HOH A O     1 ? 
HETATM 9629  O  O     . HOH X 7 .   ? -5.741  -20.548 -20.603  1    48.911  ? 974  HOH A O     1 ? 
HETATM 9630  O  O     . HOH X 7 .   ? -8.036  9.919   -8.172   1    13.801  ? 975  HOH A O     1 ? 
HETATM 9631  O  O     . HOH X 7 .   ? -15.248 -4.325  -23.705  1    40.494  ? 976  HOH A O     1 ? 
HETATM 9632  O  O     . HOH X 7 .   ? -13.588 -0.881  -17.544  1    31.955  ? 977  HOH A O     1 ? 
HETATM 9633  O  O     . HOH X 7 .   ? -14.84  17.525  -23.588  1    24.168  ? 978  HOH A O     1 ? 
HETATM 9634  O  O     . HOH X 7 .   ? 4.94    -21.072 -3.706   1    31.246  ? 979  HOH A O     1 ? 
HETATM 9635  O  O     . HOH X 7 .   ? -30.002 24.397  -14.59   1    27.916  ? 980  HOH A O     1 ? 
HETATM 9636  O  O     . HOH X 7 .   ? -20.455 23.018  5.226    1    36.089  ? 981  HOH A O     1 ? 
HETATM 9637  O  O     . HOH X 7 .   ? -8.043  13.233  8.886    1    22.937  ? 982  HOH A O     1 ? 
HETATM 9638  O  O     . HOH X 7 .   ? -0.007  -1.798  -31.864  1    32.366  ? 983  HOH A O     1 ? 
HETATM 9639  O  O     . HOH X 7 .   ? -14.394 3.62    -26.113  1    35.886  ? 984  HOH A O     1 ? 
HETATM 9640  O  O     . HOH X 7 .   ? -22.712 29.548  -44.864  1    51.624  ? 985  HOH A O     1 ? 
HETATM 9641  O  O     . HOH X 7 .   ? 15.638  -17.334 1.016    1    48.639  ? 986  HOH A O     1 ? 
HETATM 9642  O  O     . HOH X 7 .   ? -5.457  16.369  7.419    1    40.999  ? 987  HOH A O     1 ? 
HETATM 9643  O  O     . HOH X 7 .   ? -28.085 17.582  3.32     1    37.38   ? 988  HOH A O     1 ? 
HETATM 9644  O  O     . HOH X 7 .   ? -25.478 12.277  4.008    1    33.796  ? 989  HOH A O     1 ? 
HETATM 9645  O  O     . HOH X 7 .   ? -9.226  1.515   -6.172   1    16.689  ? 990  HOH A O     1 ? 
HETATM 9646  O  O     . HOH X 7 .   ? -36.153 10.59   -20.292  1    54.366  ? 991  HOH A O     1 ? 
HETATM 9647  O  O     . HOH X 7 .   ? 0.185   0.173   -33.922  1    29.846  ? 992  HOH A O     1 ? 
HETATM 9648  O  O     . HOH X 7 .   ? -17.23  18.44   -22.505  1    22.936  ? 993  HOH A O     1 ? 
HETATM 9649  O  O     . HOH X 7 .   ? -10.341 8.557   -1.915   1    23.269  ? 994  HOH A O     1 ? 
HETATM 9650  O  O     . HOH X 7 .   ? 3.275   -9.895  11.345   1    40.475  ? 995  HOH A O     1 ? 
HETATM 9651  O  O     . HOH X 7 .   ? -12.486 15.893  -12.284  1    19.708  ? 996  HOH A O     1 ? 
HETATM 9652  O  O     . HOH X 7 .   ? -9.563  19.835  -49.876  1    41.345  ? 997  HOH A O     1 ? 
HETATM 9653  O  O     . HOH X 7 .   ? -36.325 1.321   -0.653   1    39.372  ? 998  HOH A O     1 ? 
HETATM 9654  O  O     . HOH X 7 .   ? -17.272 15.003  -21.551  1    17.782  ? 999  HOH A O     1 ? 
HETATM 9655  O  O     . HOH X 7 .   ? 13.493  -9.641  1.229    1    34.792  ? 1000 HOH A O     1 ? 
HETATM 9656  O  O     . HOH X 7 .   ? -26.52  13.623  -36.613  1    63.041  ? 1001 HOH A O     1 ? 
HETATM 9657  O  O     . HOH X 7 .   ? 0.573   21.073  -21.47   1    40.481  ? 1002 HOH A O     1 ? 
HETATM 9658  O  O     . HOH X 7 .   ? -11.41  6.243   4.857    1    41.484  ? 1003 HOH A O     1 ? 
HETATM 9659  O  O     . HOH X 7 .   ? -7.828  7.619   1.805    1    37.122  ? 1004 HOH A O     1 ? 
HETATM 9660  O  O     . HOH X 7 .   ? 1.131   -10.615 -32.112  1    48.539  ? 1005 HOH A O     1 ? 
HETATM 9661  O  O     . HOH X 7 .   ? -23.092 16.261  -32.068  1    28.357  ? 1006 HOH A O     1 ? 
HETATM 9662  O  O     . HOH X 7 .   ? -16.749 18.236  -19.793  1    23.773  ? 1007 HOH A O     1 ? 
HETATM 9663  O  O     . HOH X 7 .   ? 5.903   -1.301  8.283    1    50.687  ? 1008 HOH A O     1 ? 
HETATM 9664  O  O     . HOH X 7 .   ? 7.796   0.14    -13.37   1    33.906  ? 1009 HOH A O     1 ? 
HETATM 9665  O  O     . HOH X 7 .   ? -1.211  -8.626  -32.084  1    36.51   ? 1010 HOH A O     1 ? 
HETATM 9666  O  O     . HOH X 7 .   ? -22.511 15.649  -26.021  1    24.701  ? 1011 HOH A O     1 ? 
HETATM 9667  O  O     . HOH X 7 .   ? 2.238   -18.712 -20.522  1    49.389  ? 1012 HOH A O     1 ? 
HETATM 9668  O  O     . HOH X 7 .   ? -31.043 23.712  -10.156  1    23.558  ? 1013 HOH A O     1 ? 
HETATM 9669  O  O     . HOH X 7 .   ? -14.128 15.053  -14.922  1    23.013  ? 1014 HOH A O     1 ? 
HETATM 9670  O  O     . HOH X 7 .   ? -15.345 -1.118  -30.105  1    34.579  ? 1015 HOH A O     1 ? 
HETATM 9671  O  O     . HOH X 7 .   ? -13.689 5.184   -10.651  1    19.962  ? 1016 HOH A O     1 ? 
HETATM 9672  O  O     . HOH X 7 .   ? -20.726 0.137   -28.968  1    66.24   ? 1017 HOH A O     1 ? 
HETATM 9673  O  O     . HOH X 7 .   ? 0.521   -16.619 -20.964  1    31.984  ? 1018 HOH A O     1 ? 
HETATM 9674  O  O     . HOH X 7 .   ? -0.713  15.326  -15.664  1    32.285  ? 1019 HOH A O     1 ? 
HETATM 9675  O  O     . HOH X 7 .   ? -1.78   15.389  -7.308   1    36.661  ? 1020 HOH A O     1 ? 
HETATM 9676  O  O     . HOH X 7 .   ? 8.259   -9.06   -14.665  1    38.839  ? 1021 HOH A O     1 ? 
HETATM 9677  O  O     . HOH X 7 .   ? -26.153 13.733  -31.046  1    37.887  ? 1022 HOH A O     1 ? 
HETATM 9678  O  O     . HOH X 7 .   ? -4.511  -21.085 -23.013  1    46.75   ? 1023 HOH A O     1 ? 
HETATM 9679  O  O     . HOH X 7 .   ? -18.251 11.007  1.176    1    42.113  ? 1024 HOH A O     1 ? 
HETATM 9680  O  O     . HOH X 7 .   ? -25.504 2.8     -2.538   1    22.033  ? 1025 HOH A O     1 ? 
HETATM 9681  O  O     . HOH X 7 .   ? -24.718 22.771  -26.526  1    30.405  ? 1026 HOH A O     1 ? 
HETATM 9682  O  O     . HOH X 7 .   ? 7.063   -3.499  -30.753  1    48.094  ? 1027 HOH A O     1 ? 
HETATM 9683  O  O     . HOH X 7 .   ? -17.87  -12.654 -10.683  1    28.904  ? 1028 HOH A O     1 ? 
HETATM 9684  O  O     . HOH X 7 .   ? -19.391 27.865  -43.036  1    49.208  ? 1029 HOH A O     1 ? 
HETATM 9685  O  O     . HOH X 7 .   ? 0.017   4.959   -14.765  1    22.087  ? 1030 HOH A O     1 ? 
HETATM 9686  O  O     . HOH X 7 .   ? -5.567  8.569   10.08    1    37.219  ? 1031 HOH A O     1 ? 
HETATM 9687  O  O     . HOH X 7 .   ? -29.265 17.266  -9.575   1    19.313  ? 1032 HOH A O     1 ? 
HETATM 9688  O  O     . HOH X 7 .   ? -19.244 29.922  -6.753   1    26.118  ? 1033 HOH A O     1 ? 
HETATM 9689  O  O     . HOH X 7 .   ? -14.398 25.027  -16.219  1    33.566  ? 1034 HOH A O     1 ? 
HETATM 9690  O  O     . HOH X 7 .   ? -46.488 0.599   -13.967  1    33.879  ? 1035 HOH A O     1 ? 
HETATM 9691  O  O     . HOH X 7 .   ? -5.679  24.526  -21.039  1    28.81   ? 1036 HOH A O     1 ? 
HETATM 9692  O  O     . HOH X 7 .   ? -24.373 15.601  -20.173  1    23.407  ? 1037 HOH A O     1 ? 
HETATM 9693  O  O     . HOH X 7 .   ? -14.787 30.939  -1.315   1    22.794  ? 1038 HOH A O     1 ? 
HETATM 9694  O  O     . HOH X 7 .   ? -23.29  24.801  -24.318  1    40.891  ? 1039 HOH A O     1 ? 
HETATM 9695  O  O     . HOH X 7 .   ? -24.709 14.178  -22.188  1    28.151  ? 1040 HOH A O     1 ? 
HETATM 9696  O  O     . HOH X 7 .   ? -12.047 1.52    -5.519   1    14.211  ? 1041 HOH A O     1 ? 
HETATM 9697  O  O     . HOH X 7 .   ? 3.486   11.66   -20.185  1    31.182  ? 1042 HOH A O     1 ? 
HETATM 9698  O  O     . HOH X 7 .   ? -19.752 7.969   -0.16    1    12.535  ? 1043 HOH A O     1 ? 
HETATM 9699  O  O     . HOH X 7 .   ? -30.856 15.662  -11.275  1    20.528  ? 1044 HOH A O     1 ? 
HETATM 9700  O  O     . HOH X 7 .   ? -27.069 1.052   -0.929   1    38.079  ? 1045 HOH A O     1 ? 
HETATM 9701  O  O     . HOH X 7 .   ? -27.624 -3.36   -7.524   1    24.773  ? 1046 HOH A O     1 ? 
HETATM 9702  O  O     . HOH X 7 .   ? -38.025 -9.286  -8.649   1    53.8    ? 1047 HOH A O     1 ? 
HETATM 9703  O  O     . HOH X 7 .   ? -28.781 -4.192  -10.138  1    26.255  ? 1048 HOH A O     1 ? 
HETATM 9704  O  O     . HOH X 7 .   ? -20.211 5.261   -1.264   1    21.016  ? 1049 HOH A O     1 ? 
HETATM 9705  O  O     . HOH X 7 .   ? -44.04  -6.412  -4.105   1    31.021  ? 1050 HOH A O     1 ? 
HETATM 9706  O  O     . HOH X 7 .   ? -51.03  -0.632  -12.406  1    40.244  ? 1051 HOH A O     1 ? 
HETATM 9707  O  O     . HOH X 7 .   ? -5.886  -16.388 -10.59   1    21.59   ? 1052 HOH A O     1 ? 
HETATM 9708  O  O     . HOH X 7 .   ? -13.529 25.505  -26.01   1    42.048  ? 1053 HOH A O     1 ? 
HETATM 9709  O  O     . HOH X 7 .   ? 5.457   12.862  -7.609   1    34.553  ? 1054 HOH A O     1 ? 
HETATM 9710  O  O     . HOH X 7 .   ? -27.837 2.495   -12.375  1    47.826  ? 1055 HOH A O     1 ? 
HETATM 9711  O  O     . HOH X 7 .   ? -16.149 28.604  -39.742  1    47.93   ? 1056 HOH A O     1 ? 
HETATM 9712  O  O     . HOH X 7 .   ? -1.209  -17.133 4.891    1    36.906  ? 1057 HOH A O     1 ? 
HETATM 9713  O  O     . HOH X 7 .   ? -13.784 8.037   -25.276  1    36.847  ? 1058 HOH A O     1 ? 
HETATM 9714  O  O     . HOH X 7 .   ? -12.074 23.209  -3.307   1    30.844  ? 1059 HOH A O     1 ? 
HETATM 9715  O  O     . HOH X 7 .   ? -34.404 -9.793  -6.39    1    48.658  ? 1060 HOH A O     1 ? 
HETATM 9716  O  O     . HOH X 7 .   ? -51.358 3.053   -10.301  1    36.161  ? 1061 HOH A O     1 ? 
HETATM 9717  O  O     . HOH X 7 .   ? 12.049  0.765   -3.993   1    25.77   ? 1062 HOH A O     1 ? 
HETATM 9718  O  O     . HOH X 7 .   ? 6.628   -6.004  2.501    1    29.105  ? 1063 HOH A O     1 ? 
HETATM 9719  O  O     . HOH X 7 .   ? -42.477 -7.403  -2.225   1    47.494  ? 1064 HOH A O     1 ? 
HETATM 9720  O  O     . HOH X 7 .   ? -19.921 -3.377  -17.223  1    37.533  ? 1065 HOH A O     1 ? 
HETATM 9721  O  O     . HOH X 7 .   ? -30.972 13.05   -12.112  1    22.335  ? 1066 HOH A O     1 ? 
HETATM 9722  O  O     . HOH X 7 .   ? 8.49    -12.188 -24.718  1    47.215  ? 1067 HOH A O     1 ? 
HETATM 9723  O  O     . HOH X 7 .   ? -28.051 -3.69   -14.846  1    43.429  ? 1068 HOH A O     1 ? 
HETATM 9724  O  O     . HOH X 7 .   ? -29.021 33.92   -4.222   1    38.594  ? 1069 HOH A O     1 ? 
HETATM 9725  O  O     . HOH X 7 .   ? -31.451 14.893  -8.549   1    25.535  ? 1070 HOH A O     1 ? 
HETATM 9726  O  O     . HOH X 7 .   ? -23.811 7.41    1.82     1    43.702  ? 1071 HOH A O     1 ? 
HETATM 9727  O  O     . HOH X 7 .   ? 7.783   -14.875 -20.745  1    48.876  ? 1072 HOH A O     1 ? 
HETATM 9728  O  O     . HOH X 7 .   ? 5.992   -0.984  -34.604  1    51.543  ? 1073 HOH A O     1 ? 
HETATM 9729  O  O     . HOH X 7 .   ? -19.769 20.031  -16.809  1    21.865  ? 1074 HOH A O     1 ? 
HETATM 9730  O  O     . HOH X 7 .   ? -4.684  16.452  -23.593  1    20.421  ? 1075 HOH A O     1 ? 
HETATM 9731  O  O     . HOH X 7 .   ? -14.604 11.079  11.023   1    32.373  ? 1076 HOH A O     1 ? 
HETATM 9732  O  O     . HOH X 7 .   ? -17.165 30.998  -40.489  1    44.598  ? 1077 HOH A O     1 ? 
HETATM 9733  O  O     . HOH X 7 .   ? -23.696 25.434  -19.652  1    29.552  ? 1078 HOH A O     1 ? 
HETATM 9734  O  O     . HOH X 7 .   ? -24.125 15.16   -29.737  1    30.841  ? 1079 HOH A O     1 ? 
HETATM 9735  O  O     . HOH X 7 .   ? -9.469  18.225  1.862    1    29.529  ? 1080 HOH A O     1 ? 
HETATM 9736  O  O     . HOH X 7 .   ? 9.185   -7.25   2.524    1    48.358  ? 1081 HOH A O     1 ? 
HETATM 9737  O  O     . HOH X 7 .   ? -12.331 23.624  -27.628  1    40.732  ? 1082 HOH A O     1 ? 
HETATM 9738  O  O     . HOH X 7 .   ? 4.165   13.915  -41.896  1    57.117  ? 1083 HOH A O     1 ? 
HETATM 9739  O  O     . HOH X 7 .   ? -25.924 -7.754  -16.515  1    47.861  ? 1084 HOH A O     1 ? 
HETATM 9740  O  O     . HOH X 7 .   ? 9.647   3.785   -13.094  1    35.73   ? 1085 HOH A O     1 ? 
HETATM 9741  O  O     . HOH X 7 .   ? -4.217  -11.995 12.581   1    47.726  ? 1086 HOH A O     1 ? 
HETATM 9742  O  O     . HOH X 7 .   ? -29.251 -2.929  -5.301   1    26.006  ? 1087 HOH A O     1 ? 
HETATM 9743  O  O     . HOH X 7 .   ? -33.466 33.852  -3.774   1    60.879  ? 1088 HOH A O     1 ? 
HETATM 9744  O  O     . HOH X 7 .   ? -25.239 16.425  -34.025  1    30.556  ? 1089 HOH A O     1 ? 
HETATM 9745  O  O     . HOH X 7 .   ? 8.628   6.341   -7.516   1    24.739  ? 1090 HOH A O     1 ? 
HETATM 9746  O  O     . HOH X 7 .   ? -35.442 14.998  -15.77   1    39.373  ? 1091 HOH A O     1 ? 
HETATM 9747  O  O     . HOH X 7 .   ? 13.871  -2.812  2.834    1    37.861  ? 1092 HOH A O     1 ? 
HETATM 9748  O  O     . HOH X 7 .   ? -49.313 -2.914  -2.312   1    38.717  ? 1093 HOH A O     1 ? 
HETATM 9749  O  O     . HOH X 7 .   ? 4.984   10.315  -25.859  1    61.474  ? 1094 HOH A O     1 ? 
HETATM 9750  O  O     . HOH X 7 .   ? -32.078 1.916   -13.207  1    29.441  ? 1095 HOH A O     1 ? 
HETATM 9751  O  O     . HOH X 7 .   ? -0.426  -22.355 -6.036   1    39.097  ? 1096 HOH A O     1 ? 
HETATM 9752  O  O     . HOH X 7 .   ? -7.694  28.689  -43.011  1    57.739  ? 1097 HOH A O     1 ? 
HETATM 9753  O  O     . HOH X 7 .   ? -11.622 19.915  -1.724   1    16.846  ? 1098 HOH A O     1 ? 
HETATM 9754  O  O     . HOH X 7 .   ? 3.416   6.173   -29.965  1    50.018  ? 1099 HOH A O     1 ? 
HETATM 9755  O  O     . HOH X 7 .   ? -22.757 -7.263  4.931    1    41.252  ? 1100 HOH A O     1 ? 
HETATM 9756  O  O     . HOH X 7 .   ? -2.94   9.998   -15.217  1    31.983  ? 1101 HOH A O     1 ? 
HETATM 9757  O  O     . HOH X 7 .   ? -8.175  10.802  -5.572   1    27.674  ? 1102 HOH A O     1 ? 
HETATM 9758  O  O     . HOH X 7 .   ? -32.824 21.431  -17.141  1    29.86   ? 1103 HOH A O     1 ? 
HETATM 9759  O  O     . HOH X 7 .   ? 8.397   13.228  -14.24   1    57.211  ? 1104 HOH A O     1 ? 
HETATM 9760  O  O     . HOH X 7 .   ? -20.86  5.498   -11.615  1    20.953  ? 1105 HOH A O     1 ? 
HETATM 9761  O  O     . HOH X 7 .   ? -23.207 11.087  -20.757  1    37.165  ? 1106 HOH A O     1 ? 
HETATM 9762  O  O     . HOH X 7 .   ? -1.835  21.747  -33.922  1    51.228  ? 1107 HOH A O     1 ? 
HETATM 9763  O  O     . HOH X 7 .   ? -21.217 11.739  -29.831  1    30.063  ? 1108 HOH A O     1 ? 
HETATM 9764  O  O     . HOH X 7 .   ? -17.222 10.138  7.798    1    47.559  ? 1109 HOH A O     1 ? 
HETATM 9765  O  O     . HOH X 7 .   ? 9.297   -9.903  6.248    1    33.945  ? 1110 HOH A O     1 ? 
HETATM 9766  O  O     . HOH X 7 .   ? -28.256 -3.357  -2.433   1    24.492  ? 1111 HOH A O     1 ? 
HETATM 9767  O  O     . HOH X 7 .   ? 1.449   -18.449 -27.736  1    45.344  ? 1112 HOH A O     1 ? 
HETATM 9768  O  O     . HOH X 7 .   ? -33.597 2.744   -2.961   1    37.757  ? 1113 HOH A O     1 ? 
HETATM 9769  O  O     . HOH X 7 .   ? -29.707 4.409   -2.773   1    37.905  ? 1114 HOH A O     1 ? 
HETATM 9770  O  O     . HOH X 7 .   ? -33.018 18.225  -53.878  1    48.931  ? 1115 HOH A O     1 ? 
HETATM 9771  O  O     . HOH X 7 .   ? 9.157   14.857  -24.764  1    63.435  ? 1116 HOH A O     1 ? 
HETATM 9772  O  O     . HOH X 7 .   ? -27.814 31.152  -6.878   1    39.282  ? 1117 HOH A O     1 ? 
HETATM 9773  O  O     . HOH X 7 .   ? -5.989  22.862  -12.752  1    31.021  ? 1118 HOH A O     1 ? 
HETATM 9774  O  O     . HOH X 7 .   ? -0.286  22.981  -37.886  1    48.302  ? 1119 HOH A O     1 ? 
HETATM 9775  O  O     . HOH X 7 .   ? -19.504 31.864  -5.088   1    33.973  ? 1120 HOH A O     1 ? 
HETATM 9776  O  O     . HOH X 7 .   ? -32.976 8.368   -8.002   1    37.839  ? 1121 HOH A O     1 ? 
HETATM 9777  O  O     . HOH X 7 .   ? -10.817 -12.245 10.209   1    50.773  ? 1122 HOH A O     1 ? 
HETATM 9778  O  O     . HOH X 7 .   ? -15.059 3.514   3.533    1    32.432  ? 1123 HOH A O     1 ? 
HETATM 9779  O  O     . HOH X 7 .   ? 1.761   18.761  -37.028  1    44.639  ? 1124 HOH A O     1 ? 
HETATM 9780  O  O     . HOH X 7 .   ? -34.339 -7.521  0.019    1    38.848  ? 1125 HOH A O     1 ? 
HETATM 9781  O  O     . HOH X 7 .   ? -16.084 -14.858 8.336    1    59.621  ? 1126 HOH A O     1 ? 
HETATM 9782  O  O     . HOH X 7 .   ? -7.277  -9.109  10.54    1    35.031  ? 1127 HOH A O     1 ? 
HETATM 9783  O  O     . HOH X 7 .   ? 4.296   -20.666 4.533    1    37.123  ? 1128 HOH A O     1 ? 
HETATM 9784  O  O     . HOH X 7 .   ? 10.326  -18.609 0.403    1    49.668  ? 1129 HOH A O     1 ? 
HETATM 9785  O  O     . HOH X 7 .   ? -23.267 -4.54   2.9      1    34.529  ? 1130 HOH A O     1 ? 
HETATM 9786  O  O     . HOH X 7 .   ? 2.756   15.607  -19.468  1    38.715  ? 1131 HOH A O     1 ? 
HETATM 9787  O  O     . HOH X 7 .   ? -5.261  4.589   -5.672   1    16.568  ? 1132 HOH A O     1 ? 
HETATM 9788  O  O     . HOH X 7 .   ? -19.334 -20.838 -26.658  1    59.605  ? 1133 HOH A O     1 ? 
HETATM 9789  O  O     . HOH X 7 .   ? -39.945 -6.34   0.585    1    52.437  ? 1134 HOH A O     1 ? 
HETATM 9790  O  O     . HOH X 7 .   ? 17.984  -14.69  0.67     1    59.635  ? 1135 HOH A O     1 ? 
HETATM 9791  O  O     . HOH X 7 .   ? 7.149   15.563  -15.753  1    70.961  ? 1136 HOH A O     1 ? 
HETATM 9792  O  O     . HOH X 7 .   ? 0.916   -5.539  8.017    1    38.885  ? 1137 HOH A O     1 ? 
HETATM 9793  O  O     . HOH X 7 .   ? -27.248 10.837  -47.989  1    54.226  ? 1138 HOH A O     1 ? 
HETATM 9794  O  O     . HOH X 7 .   ? -25.979 -10.146 -1.066   1    28.255  ? 1139 HOH A O     1 ? 
HETATM 9795  O  O     . HOH X 7 .   ? -26.53  6.23    -17.369  1    43.264  ? 1140 HOH A O     1 ? 
HETATM 9796  O  O     . HOH X 7 .   ? -42.164 0.423   -1.664   1    22.611  ? 1141 HOH A O     1 ? 
HETATM 9797  O  O     . HOH X 7 .   ? 10.288  -0.553  -2.21    1    33.009  ? 1142 HOH A O     1 ? 
HETATM 9798  O  O     . HOH X 7 .   ? -8.082  -14.338 10.241   1    48.241  ? 1143 HOH A O     1 ? 
HETATM 9799  O  O     . HOH X 7 .   ? 11.924  -9.739  5.26     1    50.213  ? 1144 HOH A O     1 ? 
HETATM 9800  O  O     . HOH X 7 .   ? 2.996   -19.401 -1.235   1    30.564  ? 1145 HOH A O     1 ? 
HETATM 9801  O  O     . HOH X 7 .   ? -7.693  23.617  -10.969  1    37.958  ? 1146 HOH A O     1 ? 
HETATM 9802  O  O     . HOH X 7 .   ? 5.142   -16.215 -14.413  1    42.428  ? 1147 HOH A O     1 ? 
HETATM 9803  O  O     . HOH X 7 .   ? -8.361  -1.427  5.661    1    44.327  ? 1148 HOH A O     1 ? 
HETATM 9804  O  O     . HOH X 7 .   ? -29.628 32.953  -35.628  1    47.24   ? 1149 HOH A O     1 ? 
HETATM 9805  O  O     . HOH X 7 .   ? -34.61  1.191   -9.477   1    20.414  ? 1150 HOH A O     1 ? 
HETATM 9806  O  O     . HOH X 7 .   ? -34.666 0.124   -6.951   1    25.842  ? 1151 HOH A O     1 ? 
HETATM 9807  O  O     . HOH X 7 .   ? -21.506 -12.06  5.331    1    48.752  ? 1152 HOH A O     1 ? 
HETATM 9808  O  O     . HOH X 7 .   ? -35.77  0.931   -4.322   1    29.78   ? 1153 HOH A O     1 ? 
HETATM 9809  O  O     . HOH X 7 .   ? -34.123 24.441  -28.028  1    48.572  ? 1154 HOH A O     1 ? 
HETATM 9810  O  O     . HOH X 7 .   ? -30.849 1.52    3.815    1    52.051  ? 1155 HOH A O     1 ? 
HETATM 9811  O  O     . HOH X 7 .   ? -27.049 6.286   -23.978  1    48.414  ? 1156 HOH A O     1 ? 
HETATM 9812  O  O     . HOH X 7 .   ? -27.084 22.688  -21.5    1    43.12   ? 1157 HOH A O     1 ? 
HETATM 9813  O  O     . HOH X 7 .   ? -46.989 -5.959  -3.15    1    45.106  ? 1158 HOH A O     1 ? 
HETATM 9814  O  O     . HOH X 7 .   ? 0.955   21.327  -34.41   1    52.816  ? 1159 HOH A O     1 ? 
HETATM 9815  O  O     . HOH X 7 .   ? -23.012 -8.086  -14.974  1    34.264  ? 1160 HOH A O     1 ? 
HETATM 9816  O  O     . HOH X 7 .   ? -6.603  -4.355  5.129    1    39.019  ? 1161 HOH A O     1 ? 
HETATM 9817  O  O     . HOH X 7 .   ? -15.784 27.398  -22.204  1    47.669  ? 1162 HOH A O     1 ? 
HETATM 9818  O  O     . HOH X 7 .   ? -5.681  16.899  -0.051   1    56.55   ? 1163 HOH A O     1 ? 
HETATM 9819  O  O     . HOH X 7 .   ? -23.025 27.101  -17.385  1    47.049  ? 1164 HOH A O     1 ? 
HETATM 9820  O  O     . HOH X 7 .   ? -19.484 26.976  -18.228  1    45.389  ? 1165 HOH A O     1 ? 
HETATM 9821  O  O     . HOH X 7 .   ? 11.371  -5.892  -21.717  1    55.365  ? 1166 HOH A O     1 ? 
HETATM 9822  O  O     . HOH X 7 .   ? -7.532  21.208  -9.705   1    27.056  ? 1167 HOH A O     1 ? 
HETATM 9823  O  O     . HOH X 7 .   ? -48.117 6.338   -15.323  1    50.981  ? 1168 HOH A O     1 ? 
HETATM 9824  O  O     . HOH X 7 .   ? -26.936 2.834   -14.775  1    49.445  ? 1169 HOH A O     1 ? 
HETATM 9825  O  O     . HOH X 7 .   ? -19.246 25.515  -46.575  1    49.178  ? 1170 HOH A O     1 ? 
HETATM 9826  O  O     . HOH X 7 .   ? -14.246 -15.09  -5.004   1    48.001  ? 1171 HOH A O     1 ? 
HETATM 9827  O  O     . HOH X 7 .   ? -29.369 -7.22   -17.156  1    58.773  ? 1172 HOH A O     1 ? 
HETATM 9828  O  O     . HOH X 7 .   ? 10.466  6.532   -13.494  1    43.341  ? 1173 HOH A O     1 ? 
HETATM 9829  O  O     . HOH X 7 .   ? -47.99  -6.285  -7.448   1    37.74   ? 1174 HOH A O     1 ? 
HETATM 9830  O  O     . HOH X 7 .   ? -14.435 14.538  12.84    1    40.903  ? 1175 HOH A O     1 ? 
HETATM 9831  O  O     . HOH X 7 .   ? -28.992 31.974  -45.656  1    62.45   ? 1176 HOH A O     1 ? 
HETATM 9832  O  O     . HOH X 7 .   ? -2.739  10.8    -19.231  1    31.29   ? 1177 HOH A O     1 ? 
HETATM 9833  O  O     . HOH X 7 .   ? 1.577   22.305  -43.199  1    49.674  ? 1178 HOH A O     1 ? 
HETATM 9834  O  O     . HOH X 7 .   ? -22.794 -10.105 -11.309  1    47.062  ? 1179 HOH A O     1 ? 
HETATM 9835  O  O     . HOH X 7 .   ? -21.396 -2.613  -37.876  1    50.192  ? 1180 HOH A O     1 ? 
HETATM 9836  O  O     . HOH X 7 .   ? -15.744 23.949  -45.505  1    52.134  ? 1181 HOH A O     1 ? 
HETATM 9837  O  O     . HOH X 7 .   ? -48.246 -1.439  -1.097   1    35.209  ? 1182 HOH A O     1 ? 
HETATM 9838  O  O     . HOH X 7 .   ? -6.157  -15.831 9.468    1    46.245  ? 1183 HOH A O     1 ? 
HETATM 9839  O  O     . HOH X 7 .   ? -20.173 30.922  -15.295  1    44.101  ? 1184 HOH A O     1 ? 
HETATM 9840  O  O     . HOH X 7 .   ? 11.674  -14.044 -4.321   1    40.045  ? 1185 HOH A O     1 ? 
HETATM 9841  O  O     . HOH X 7 .   ? -32.409 17.737  -0.055   1    41.4    ? 1186 HOH A O     1 ? 
HETATM 9842  O  O     . HOH X 7 .   ? 16.243  -3.991  -26.868  1    57.266  ? 1187 HOH A O     1 ? 
HETATM 9843  O  O     . HOH X 7 .   ? -10.242 9.053   -4.565   1    23.136  ? 1188 HOH A O     1 ? 
HETATM 9844  O  O     . HOH X 7 .   ? 8.057   12.506  -7.421   1    36.437  ? 1189 HOH A O     1 ? 
HETATM 9845  O  O     . HOH X 7 .   ? -5.783  20.211  -5.769   1    48.84   ? 1190 HOH A O     1 ? 
HETATM 9846  O  O     . HOH X 7 .   ? 3.887   18.157  -20.324  1    45.15   ? 1191 HOH A O     1 ? 
HETATM 9847  O  O     . HOH X 7 .   ? -21.232 10.799  3.377    1    51.776  ? 1192 HOH A O     1 ? 
HETATM 9848  O  O     . HOH X 7 .   ? 4.02    21.7    -42.114  1    52.96   ? 1193 HOH A O     1 ? 
HETATM 9849  O  O     . HOH X 7 .   ? -23.965 -2.853  -14.788  1    37.963  ? 1194 HOH A O     1 ? 
HETATM 9850  O  O     . HOH X 7 .   ? -30.544 7.496   -6.872   1    39.506  ? 1195 HOH A O     1 ? 
HETATM 9851  O  O     . HOH X 7 .   ? -20.961 3.747   -19.419  1    55.648  ? 1196 HOH A O     1 ? 
HETATM 9852  O  O     . HOH X 7 .   ? -19.628 -6.29   10.076   1    54.351  ? 1197 HOH A O     1 ? 
HETATM 9853  O  O     . HOH X 7 .   ? 7.521   7.302   -20.523  1    37.76   ? 1198 HOH A O     1 ? 
HETATM 9854  O  O     . HOH X 7 .   ? 2.672   5.854   -27.39   1    49.952  ? 1199 HOH A O     1 ? 
HETATM 9855  O  O     . HOH X 7 .   ? -9.56   -14.596 0.911    1    57.752  ? 1200 HOH A O     1 ? 
HETATM 9856  O  O     . HOH X 7 .   ? 11.584  -11.901 -5.762   1    43.193  ? 1201 HOH A O     1 ? 
HETATM 9857  O  O     . HOH X 7 .   ? -12.712 33.902  -3.79    1    49.832  ? 1202 HOH A O     1 ? 
HETATM 9858  O  O     . HOH X 7 .   ? -12.665 -3.819  -20.096  1    41.237  ? 1203 HOH A O     1 ? 
HETATM 9859  O  O     . HOH X 7 .   ? -18.417 -12.982 3.778    1    49.962  ? 1204 HOH A O     1 ? 
HETATM 9860  O  O     . HOH X 7 .   ? -13.588 4.845   -33.169  1    57.634  ? 1205 HOH A O     1 ? 
HETATM 9861  O  O     . HOH X 7 .   ? 14.242  -15.706 5.515    1    53.408  ? 1206 HOH A O     1 ? 
HETATM 9862  O  O     . HOH X 7 .   ? -14.242 30.553  1.311    1    22.732  ? 1207 HOH A O     1 ? 
HETATM 9863  O  O     . HOH X 7 .   ? -36.975 20.146  -18.676  1    60.995  ? 1208 HOH A O     1 ? 
HETATM 9864  O  O     . HOH X 7 .   ? -35.059 15.534  -53.422  1    56.566  ? 1209 HOH A O     1 ? 
HETATM 9865  O  O     . HOH X 7 .   ? 15.067  -7.601  -0.756   1    48.75   ? 1210 HOH A O     1 ? 
HETATM 9866  O  O     . HOH X 7 .   ? 5.108   -19.698 0.388    1    43.476  ? 1211 HOH A O     1 ? 
HETATM 9867  O  O     . HOH X 7 .   ? 6.091   -12.503 -29.846  1    48.738  ? 1212 HOH A O     1 ? 
HETATM 9868  O  O     . HOH X 7 .   ? -11.583 -24.873 -23.371  1    60.76   ? 1213 HOH A O     1 ? 
HETATM 9869  O  O     . HOH X 7 .   ? -25.286 9.606   -20.663  1    46.247  ? 1214 HOH A O     1 ? 
HETATM 9870  O  O     . HOH X 7 .   ? 5.953   15.884  -28.423  1    57.648  ? 1215 HOH A O     1 ? 
HETATM 9871  O  O     . HOH X 7 .   ? -29.164 23.182  -19.619  1    41.916  ? 1216 HOH A O     1 ? 
HETATM 9872  O  O     . HOH X 7 .   ? 7.887   -14.494 10.917   1    63.144  ? 1217 HOH A O     1 ? 
HETATM 9873  O  O     . HOH X 7 .   ? -32.605 -7.283  -14.379  1    46.969  ? 1218 HOH A O     1 ? 
HETATM 9874  O  O     . HOH X 7 .   ? -25.814 3.218   -18.715  1    47.552  ? 1219 HOH A O     1 ? 
HETATM 9875  O  O     . HOH X 7 .   ? 9.57    -15.097 -7.622   1    34.383  ? 1220 HOH A O     1 ? 
HETATM 9876  O  O     . HOH X 7 .   ? 18.739  -17.53  0.634    1    57.117  ? 1221 HOH A O     1 ? 
HETATM 9877  O  O     . HOH X 7 .   ? -7.367  24.926  -23.147  1    42.707  ? 1222 HOH A O     1 ? 
HETATM 9878  O  O     . HOH X 7 .   ? -2.593  -10.613 -42.772  1    53.327  ? 1223 HOH A O     1 ? 
HETATM 9879  O  O     . HOH X 7 .   ? -17.572 -9.929  -33.743  1    52.374  ? 1224 HOH A O     1 ? 
HETATM 9880  O  O     . HOH X 7 .   ? 8.269   -17.559 -8.574   1    57.135  ? 1225 HOH A O     1 ? 
HETATM 9881  O  O     . HOH X 7 .   ? -13.432 -14.489 8.293    1    49.939  ? 1226 HOH A O     1 ? 
HETATM 9882  O  O     . HOH X 7 .   ? -3.905  -17.347 -32.451  1    63.69   ? 1227 HOH A O     1 ? 
HETATM 9883  O  O     . HOH X 7 .   ? -12.76  2.218   3.964    1    38.392  ? 1228 HOH A O     1 ? 
HETATM 9884  O  O     . HOH X 7 .   ? -10.342 27.873  -11.797  1    64.032  ? 1229 HOH A O     1 ? 
HETATM 9885  O  O     . HOH X 7 .   ? -28.94  -9.007  0.061    1    60.159  ? 1230 HOH A O     1 ? 
HETATM 9886  O  O     . HOH X 7 .   ? -6.512  13.504  6.759    1    26.788  ? 1231 HOH A O     1 ? 
HETATM 9887  O  O     . HOH X 7 .   ? -9.514  20.628  0        1    33.331  ? 1232 HOH A O     1 ? 
HETATM 9888  O  O     . HOH X 7 .   ? -34.124 10.64   -8.582   1    52.733  ? 1233 HOH A O     1 ? 
HETATM 9889  O  O     . HOH X 7 .   ? 0.665   -13.209 -41.081  1    51.77   ? 1234 HOH A O     1 ? 
HETATM 9890  O  O     . HOH X 7 .   ? -39.218 17.643  -47.176  1    54.158  ? 1235 HOH A O     1 ? 
HETATM 9891  O  O     . HOH X 7 .   ? -26.438 -1.52   -1.342   1    27.12   ? 1236 HOH A O     1 ? 
HETATM 9892  O  O     . HOH X 7 .   ? -0.096  12.093  -18.16   1    35.629  ? 1237 HOH A O     1 ? 
HETATM 9893  O  O     . HOH X 7 .   ? 9.959   2.385   -15.005  1    38.511  ? 1238 HOH A O     1 ? 
HETATM 9894  O  O     . HOH X 7 .   ? -20.969 -11.107 -13.757  1    64.509  ? 1239 HOH A O     1 ? 
HETATM 9895  O  O     . HOH X 7 .   ? -22.16  3.882   -0.242   1    33.324  ? 1240 HOH A O     1 ? 
HETATM 9896  O  O     . HOH X 7 .   ? -22.715 7.022   -21.518  1    49.869  ? 1241 HOH A O     1 ? 
HETATM 9897  O  O     . HOH X 7 .   ? -23.226 33.682  -12.328  1    54.143  ? 1242 HOH A O     1 ? 
HETATM 9898  O  O     . HOH X 7 .   ? -22.61  -3.848  -16.486  1    46.92   ? 1243 HOH A O     1 ? 
HETATM 9899  O  O     . HOH X 7 .   ? -12.129 28.714  -28.997  1    60.019  ? 1244 HOH A O     1 ? 
HETATM 9900  O  O     . HOH X 7 .   ? -11.723 29.904  -4.187   1    51.574  ? 1245 HOH A O     1 ? 
HETATM 9901  O  O     . HOH X 7 .   ? -26.785 18.277  5.44     1    40.608  ? 1246 HOH A O     1 ? 
HETATM 9902  O  O     . HOH X 7 .   ? 13.52   -0.694  1.258    1    27.068  ? 1247 HOH A O     1 ? 
HETATM 9903  O  O     . HOH X 7 .   ? 3.43    19.274  -51.458  1    54.858  ? 1248 HOH A O     1 ? 
HETATM 9904  O  O     . HOH X 7 .   ? 3.391   27.216  -16.789  1    56.11   ? 1249 HOH A O     1 ? 
HETATM 9905  O  O     . HOH X 7 .   ? -2.362  -16.011 -34.638  1    62.296  ? 1250 HOH A O     1 ? 
HETATM 9906  O  O     . HOH X 7 .   ? -7.54   -19.677 -9.48    1    42.407  ? 1251 HOH A O     1 ? 
HETATM 9907  O  O     . HOH X 7 .   ? -49.997 -7.313  -8.759   1    30.895  ? 1252 HOH A O     1 ? 
HETATM 9908  O  O     . HOH X 7 .   ? 4.17    -18.374 3.213    1    30.852  ? 1253 HOH A O     1 ? 
HETATM 9909  O  O     . HOH X 7 .   ? -1.126  11.682  -15.168  1    41.581  ? 1254 HOH A O     1 ? 
HETATM 9910  O  O     . HOH X 7 .   ? -9.848  26.851  -15.959  1    56.924  ? 1255 HOH A O     1 ? 
HETATM 9911  O  O     . HOH X 7 .   ? -5.498  24.852  -14.823  1    40.082  ? 1256 HOH A O     1 ? 
HETATM 9912  O  O     . HOH X 7 .   ? 7.987   8.289   -23.162  1    36.685  ? 1257 HOH A O     1 ? 
HETATM 9913  O  O     . HOH X 7 .   ? -17.709 20.366  -18.507  1    20.128  ? 1258 HOH A O     1 ? 
HETATM 9914  O  O     . HOH X 7 .   ? -30.432 22.499  -16.967  1    33.871  ? 1259 HOH A O     1 ? 
HETATM 9915  O  O     . HOH X 7 .   ? -31.351 -10.43  -1.077   1    47.475  ? 1260 HOH A O     1 ? 
HETATM 9916  O  O     . HOH X 7 .   ? -33.221 16.08   -6.792   1    34.965  ? 1261 HOH A O     1 ? 
HETATM 9917  O  O     . HOH X 7 .   ? -3.52   -16.97  4.188    1    45.315  ? 1262 HOH A O     1 ? 
HETATM 9918  O  O     . HOH X 7 .   ? 0.977   21.742  -24.665  1    57.992  ? 1263 HOH A O     1 ? 
HETATM 9919  O  O     . HOH X 7 .   ? -7.097  29.801  3.171    1    35.927  ? 1264 HOH A O     1 ? 
HETATM 9920  O  O     . HOH X 7 .   ? -9.867  -25.32  -21.471  1    61.338  ? 1265 HOH A O     1 ? 
HETATM 9921  O  O     . HOH X 7 .   ? 9.083   -11.317 -9.439   1    40.788  ? 1266 HOH A O     1 ? 
HETATM 9922  O  O     . HOH X 7 .   ? -33.514 14.379  -4.561   1    40.135  ? 1267 HOH A O     1 ? 
HETATM 9923  O  O     . HOH X 7 .   ? -29.404 26.441  -16.084  1    53.885  ? 1268 HOH A O     1 ? 
HETATM 9924  O  O     . HOH X 7 .   ? -4.096  9.85    -17.555  1    48.973  ? 1269 HOH A O     1 ? 
HETATM 9925  O  O     . HOH X 7 .   ? -32.543 22.827  -7.62    1    25.472  ? 1270 HOH A O     1 ? 
HETATM 9926  O  O     . HOH X 7 .   ? -24.174 0.345   1.689    1    49.41   ? 1271 HOH A O     1 ? 
HETATM 9927  O  O     . HOH X 7 .   ? -32.688 12.625  -10.204  1    31.964  ? 1272 HOH A O     1 ? 
HETATM 9928  O  O     . HOH X 7 .   ? -14.77  16.923  -12.867  1    25.191  ? 1273 HOH A O     1 ? 
HETATM 9929  O  O     . HOH X 7 .   ? -8.029  -18.126 -2.557   1    57.632  ? 1274 HOH A O     1 ? 
HETATM 9930  O  O     . HOH X 7 .   ? -32.852 34.941  -5.697   1    50.529  ? 1275 HOH A O     1 ? 
HETATM 9931  O  O     . HOH X 7 .   ? -11.589 31.622  -32.676  1    46.898  ? 1276 HOH A O     1 ? 
HETATM 9932  O  O     . HOH X 7 .   ? -8.043  23.951  -6.294   1    38.199  ? 1277 HOH A O     1 ? 
HETATM 9933  O  O     . HOH X 7 .   ? -7.397  25.419  -9.221   1    43.531  ? 1278 HOH A O     1 ? 
HETATM 9934  O  O     . HOH X 7 .   ? -9.028  -10.752 11.563   1    39.896  ? 1279 HOH A O     1 ? 
HETATM 9935  O  O     . HOH X 7 .   ? -20.155 -11.565 -11.461  1    53.895  ? 1280 HOH A O     1 ? 
HETATM 9936  O  O     . HOH X 7 .   ? -5.464  -20.535 -0.134   1    49.263  ? 1281 HOH A O     1 ? 
HETATM 9937  O  O     . HOH X 7 .   ? -20.398 2.628   -29.864  1    47.353  ? 1282 HOH A O     1 ? 
HETATM 9938  O  O     . HOH X 7 .   ? 1.905   -4.302  3.802    1    28.687  ? 1283 HOH A O     1 ? 
HETATM 9939  O  O     . HOH X 7 .   ? -9.441  6.337   3.431    1    40.384  ? 1284 HOH A O     1 ? 
HETATM 9940  O  O     . HOH X 7 .   ? -1.807  17.935  -8.138   1    31.975  ? 1285 HOH A O     1 ? 
HETATM 9941  O  O     . HOH X 7 .   ? -19.028 -13.316 -32.911  1    47.794  ? 1286 HOH A O     1 ? 
HETATM 9942  O  O     . HOH X 7 .   ? 4.714   -4.738  4.709    1    44.095  ? 1287 HOH A O     1 ? 
HETATM 9943  O  O     . HOH X 7 .   ? -4.525  -9.527  11.625   1    39.782  ? 1288 HOH A O     1 ? 
HETATM 9944  O  O     . HOH X 7 .   ? -0.843  14.439  -10.012  1    45.033  ? 1289 HOH A O     1 ? 
HETATM 9945  O  O     . HOH X 7 .   ? -24.417 5.343   0.656    1    37.267  ? 1290 HOH A O     1 ? 
HETATM 9946  O  O     . HOH X 7 .   ? -39.182 14.399  -22.412  1    53.475  ? 1291 HOH A O     1 ? 
HETATM 9947  O  O     . HOH X 7 .   ? -10.945 -14.942 10.325   1    56.865  ? 1292 HOH A O     1 ? 
HETATM 9948  O  O     . HOH X 7 .   ? -0.552  24.003  -33.936  1    48.01   ? 1293 HOH A O     1 ? 
HETATM 9949  O  O     . HOH X 7 .   ? -32.035 24.721  -12.456  1    43.594  ? 1294 HOH A O     1 ? 
HETATM 9950  O  O     . HOH X 7 .   ? -23.035 2.144   -2.017   1    24.859  ? 1295 HOH A O     1 ? 
HETATM 9951  O  O     . HOH X 7 .   ? -12.402 31.653  -2.353   1    29.744  ? 1296 HOH A O     1 ? 
HETATM 9952  O  O     . HOH X 7 .   ? -33.095 21.796  -22.252  1    39.992  ? 1297 HOH A O     1 ? 
HETATM 9953  O  O     . HOH X 7 .   ? -28.639 22.982  -23.831  1    36.218  ? 1298 HOH A O     1 ? 
HETATM 9954  O  O     . HOH X 7 .   ? 8.619   -7.218  -17.841  1    38.59   ? 1299 HOH A O     1 ? 
HETATM 9955  O  O     . HOH X 7 .   ? -32.763 18.959  -6.028   1    20.231  ? 1300 HOH A O     1 ? 
HETATM 9956  O  O     . HOH X 7 .   ? -7.538  -6.309  12.303   1    44.626  ? 1301 HOH A O     1 ? 
HETATM 9957  O  O     . HOH X 7 .   ? -28.033 25.839  -19.137  1    53.058  ? 1302 HOH A O     1 ? 
HETATM 9958  O  O     . HOH X 7 .   ? -4.732  9.545   7.489    1    34.591  ? 1303 HOH A O     1 ? 
HETATM 9959  O  O     . HOH X 7 .   ? -26.767 7.341   -19.921  1    53.699  ? 1304 HOH A O     1 ? 
HETATM 9960  O  O     . HOH X 7 .   ? -37.658 -10.089 -5.282   1    47.422  ? 1305 HOH A O     1 ? 
HETATM 9961  O  O     . HOH X 7 .   ? -28.232 15.358  -33.6    1    49.685  ? 1306 HOH A O     1 ? 
HETATM 9962  O  O     . HOH X 7 .   ? -4.839  11.69   6.102    1    31.518  ? 1307 HOH A O     1 ? 
HETATM 9963  O  O     . HOH X 7 .   ? -33.333 26.555  -8.174   1    41.84   ? 1308 HOH A O     1 ? 
HETATM 9964  O  O     . HOH X 7 .   ? -1.686  33.476  -43.388  1    64.362  ? 1309 HOH A O     1 ? 
HETATM 9965  O  O     . HOH X 7 .   ? 0.422   33.434  -41.362  1    63.696  ? 1310 HOH A O     1 ? 
HETATM 9966  O  O     . HOH X 7 .   ? 3.178   22.472  -15.908  1    51.956  ? 1311 HOH A O     1 ? 
HETATM 9967  O  O     . HOH X 7 .   ? 3.982   22.13   -26.048  1    54.515  ? 1312 HOH A O     1 ? 
HETATM 9968  O  O     . HOH X 7 .   ? -37.728 29.414  -38.982  1    56.066  ? 1313 HOH A O     1 ? 
HETATM 9969  O  O     . HOH Y 7 .   ? 1.728   -19.835 -94.911  1    46.354  ? 801  HOH B O     1 ? 
HETATM 9970  O  O     . HOH Y 7 .   ? -25.17  -23.576 -55.328  1    43.566  ? 802  HOH B O     1 ? 
HETATM 9971  O  O     . HOH Y 7 .   ? -0.509  3.794   -80.964  1    61.054  ? 803  HOH B O     1 ? 
HETATM 9972  O  O     . HOH Y 7 .   ? -15.286 -26.881 -79.015  1    42.196  ? 804  HOH B O     1 ? 
HETATM 9973  O  O     . HOH Y 7 .   ? -3.441  -23.562 -84.02   1    33.155  ? 805  HOH B O     1 ? 
HETATM 9974  O  O     . HOH Y 7 .   ? 2.423   -3.151  -66.933  1    57.043  ? 806  HOH B O     1 ? 
HETATM 9975  O  O     . HOH Y 7 .   ? -36.39  -18.945 -58.503  1    48.022  ? 807  HOH B O     1 ? 
HETATM 9976  O  O     . HOH Y 7 .   ? -21.097 -27.572 -68.05   1    42.387  ? 808  HOH B O     1 ? 
HETATM 9977  O  O     . HOH Y 7 .   ? -22.58  -27.821 -40.503  1    47.126  ? 809  HOH B O     1 ? 
HETATM 9978  O  O     . HOH Y 7 .   ? -27.075 -5.475  -78.212  1    35.078  ? 810  HOH B O     1 ? 
HETATM 9979  O  O     . HOH Y 7 .   ? -24.272 -4.477  -71.394  1    63.227  ? 811  HOH B O     1 ? 
HETATM 9980  O  O     . HOH Y 7 .   ? -10.527 -10.759 -95.985  1    41.957  ? 812  HOH B O     1 ? 
HETATM 9981  O  O     . HOH Y 7 .   ? -17.781 -13.977 -91      1    40.18   ? 813  HOH B O     1 ? 
HETATM 9982  O  O     . HOH Y 7 .   ? -2.857  -27.098 -85.087  1    42.232  ? 814  HOH B O     1 ? 
HETATM 9983  O  O     . HOH Y 7 .   ? -10.603 -23.904 -49.222  1    49.546  ? 815  HOH B O     1 ? 
HETATM 9984  O  O     . HOH Y 7 .   ? -30.357 -19.927 -73.665  1    43.76   ? 816  HOH B O     1 ? 
HETATM 9985  O  O     . HOH Y 7 .   ? -11.004 -26.639 -71.424  1    40.905  ? 817  HOH B O     1 ? 
HETATM 9986  O  O     . HOH Y 7 .   ? -22.768 3.293   -91.875  1    39.438  ? 818  HOH B O     1 ? 
HETATM 9987  O  O     . HOH Y 7 .   ? -20.299 -19.16  -77.014  1    31.602  ? 819  HOH B O     1 ? 
HETATM 9988  O  O     . HOH Y 7 .   ? -11.197 -11.656 -93.498  1    44.519  ? 820  HOH B O     1 ? 
HETATM 9989  O  O     . HOH Y 7 .   ? -43.58  2.866   -74.994  1    57.528  ? 821  HOH B O     1 ? 
HETATM 9990  O  O     . HOH Y 7 .   ? -33.856 -10.151 -71.839  1    26.956  ? 822  HOH B O     1 ? 
HETATM 9991  O  O     . HOH Y 7 .   ? -32.564 -0.389  -52.744  1    48.601  ? 823  HOH B O     1 ? 
HETATM 9992  O  O     . HOH Y 7 .   ? -22.029 -20.351 -83.241  1    31.003  ? 824  HOH B O     1 ? 
HETATM 9993  O  O     . HOH Y 7 .   ? -35.685 -25.376 -46.609  1    58.393  ? 825  HOH B O     1 ? 
HETATM 9994  O  O     . HOH Y 7 .   ? -5.527  3.328   -77.92   1    48.147  ? 826  HOH B O     1 ? 
HETATM 9995  O  O     . HOH Y 7 .   ? -19.838 -10.83  -52.744  1    51.765  ? 827  HOH B O     1 ? 
HETATM 9996  O  O     . HOH Y 7 .   ? -26.043 -22.341 -86.859  1    31.296  ? 828  HOH B O     1 ? 
HETATM 9997  O  O     . HOH Y 7 .   ? -35.285 7.386   -93.515  1    42.658  ? 829  HOH B O     1 ? 
HETATM 9998  O  O     . HOH Y 7 .   ? -32.66  3.314   -78.717  1    39.501  ? 830  HOH B O     1 ? 
HETATM 9999  O  O     . HOH Y 7 .   ? -9.682  -25.255 -63.231  1    44.843  ? 831  HOH B O     1 ? 
HETATM 10000 O  O     . HOH Y 7 .   ? -29.826 -4.999  -57.98   1    60.365  ? 832  HOH B O     1 ? 
HETATM 10001 O  O     . HOH Y 7 .   ? -22.654 -24.447 -72.663  1    47.151  ? 833  HOH B O     1 ? 
HETATM 10002 O  O     . HOH Y 7 .   ? -25.694 -22.541 -52.942  1    50.652  ? 834  HOH B O     1 ? 
HETATM 10003 O  O     . HOH Y 7 .   ? -16.745 15.574  -78.503  1    49.292  ? 835  HOH B O     1 ? 
HETATM 10004 O  O     . HOH Y 7 .   ? -19.256 -17.36  -88.889  1    46.054  ? 836  HOH B O     1 ? 
HETATM 10005 O  O     . HOH Y 7 .   ? -39.555 11.059  -74.79   1    47.241  ? 837  HOH B O     1 ? 
HETATM 10006 O  O     . HOH Y 7 .   ? -15.773 13.399  -76.579  1    59.901  ? 838  HOH B O     1 ? 
HETATM 10007 O  O     . HOH Y 7 .   ? -38.413 -6.668  -74.993  1    42.717  ? 839  HOH B O     1 ? 
HETATM 10008 O  O     . HOH Y 7 .   ? -43.372 14.984  -90.441  1    48.578  ? 840  HOH B O     1 ? 
HETATM 10009 O  O     . HOH Y 7 .   ? -10.644 -4.731  -66.437  1    44.71   ? 841  HOH B O     1 ? 
HETATM 10010 O  O     . HOH Y 7 .   ? -37.2   -19.574 -78.561  1    39.571  ? 842  HOH B O     1 ? 
HETATM 10011 O  O     . HOH Y 7 .   ? -17.819 7.319   -86.476  1    42.036  ? 843  HOH B O     1 ? 
HETATM 10012 O  O     . HOH Y 7 .   ? -10.671 -28.459 -75.029  1    57.439  ? 844  HOH B O     1 ? 
HETATM 10013 O  O     . HOH Y 7 .   ? -17.009 -33.798 -67.603  1    59.421  ? 845  HOH B O     1 ? 
HETATM 10014 O  O     . HOH Y 7 .   ? -36.618 13.326  -90.073  1    34.41   ? 846  HOH B O     1 ? 
HETATM 10015 O  O     . HOH Y 7 .   ? -11.106 -5.981  -73.66   1    44.62   ? 847  HOH B O     1 ? 
HETATM 10016 O  O     . HOH Y 7 .   ? -5.445  3.637   -80.808  1    50.057  ? 848  HOH B O     1 ? 
HETATM 10017 O  O     . HOH Y 7 .   ? -32.331 10.648  -79.509  1    48.165  ? 849  HOH B O     1 ? 
HETATM 10018 O  O     . HOH Y 7 .   ? 0.222   -24.012 -96.718  1    45.181  ? 850  HOH B O     1 ? 
HETATM 10019 O  O     . HOH Y 7 .   ? -21.505 6.174   -72.081  1    43.038  ? 851  HOH B O     1 ? 
HETATM 10020 O  O     . HOH Y 7 .   ? -21.36  -28.788 -54.636  1    56.86   ? 852  HOH B O     1 ? 
HETATM 10021 O  O     . HOH Y 7 .   ? -23.119 1.834   -89.534  1    35.975  ? 853  HOH B O     1 ? 
HETATM 10022 O  O     . HOH Y 7 .   ? -25.087 -10.858 -83.072  1    26.76   ? 854  HOH B O     1 ? 
HETATM 10023 O  O     . HOH Y 7 .   ? -12.186 -27.466 -61.561  1    55.956  ? 855  HOH B O     1 ? 
HETATM 10024 O  O     . HOH Y 7 .   ? -17.666 8.321   -76.229  1    42.451  ? 856  HOH B O     1 ? 
HETATM 10025 O  O     . HOH Y 7 .   ? -13.459 -20.208 -59.881  1    39.059  ? 857  HOH B O     1 ? 
HETATM 10026 O  O     . HOH Y 7 .   ? -28.757 2.949   -96.356  1    50.681  ? 858  HOH B O     1 ? 
HETATM 10027 O  O     . HOH Y 7 .   ? -33.872 -23.183 -55.254  1    44.048  ? 859  HOH B O     1 ? 
HETATM 10028 O  O     . HOH Y 7 .   ? -25.428 -26.555 -55.341  1    66.946  ? 860  HOH B O     1 ? 
HETATM 10029 O  O     . HOH Y 7 .   ? -33.025 -14.149 -83.917  1    60.866  ? 861  HOH B O     1 ? 
HETATM 10030 O  O     . HOH Y 7 .   ? -14.228 -5.173  -46.454  1    42.42   ? 862  HOH B O     1 ? 
HETATM 10031 O  O     . HOH Y 7 .   ? -28.43  -27.575 -77.812  1    54.883  ? 863  HOH B O     1 ? 
HETATM 10032 O  O     . HOH Y 7 .   ? -20.274 4.828   -77.112  1    42.823  ? 864  HOH B O     1 ? 
HETATM 10033 O  O     . HOH Y 7 .   ? -11.836 5.936   -88.076  1    46.96   ? 865  HOH B O     1 ? 
HETATM 10034 O  O     . HOH Y 7 .   ? -35.871 -13.253 -41.512  1    51.902  ? 866  HOH B O     1 ? 
HETATM 10035 O  O     . HOH Y 7 .   ? -24.369 -6.305  -77.55   1    39.29   ? 867  HOH B O     1 ? 
HETATM 10036 O  O     . HOH Y 7 .   ? -26.083 0.281   -90.968  1    43.022  ? 868  HOH B O     1 ? 
HETATM 10037 O  O     . HOH Y 7 .   ? -30.865 -21.91  -80.585  1    50.002  ? 869  HOH B O     1 ? 
HETATM 10038 O  O     . HOH Y 7 .   ? -39.366 16.014  -88.182  1    51.623  ? 870  HOH B O     1 ? 
HETATM 10039 O  O     . HOH Y 7 .   ? 9.633   -6.107  -69.314  1    59.573  ? 871  HOH B O     1 ? 
HETATM 10040 O  O     . HOH Y 7 .   ? -20.159 -18.137 -79.427  1    28.436  ? 872  HOH B O     1 ? 
HETATM 10041 O  O     . HOH Y 7 .   ? -33.614 -5.012  -67.364  1    44.42   ? 873  HOH B O     1 ? 
HETATM 10042 O  O     . HOH Y 7 .   ? -26.848 -32.774 -39.898  1    36.63   ? 874  HOH B O     1 ? 
HETATM 10043 O  O     . HOH Y 7 .   ? -38.07  -21.192 -54.657  1    50.559  ? 875  HOH B O     1 ? 
HETATM 10044 O  O     . HOH Y 7 .   ? -16.663 -6.56   -85.038  1    31.393  ? 876  HOH B O     1 ? 
HETATM 10045 O  O     . HOH Y 7 .   ? -42.128 -6.363  -93.398  1    53.38   ? 877  HOH B O     1 ? 
HETATM 10046 O  O     . HOH Y 7 .   ? -16.618 -27.044 -76.063  1    45.317  ? 878  HOH B O     1 ? 
HETATM 10047 O  O     A HOH Y 7 .   ? -34.237 -2.787  -67.996  0.5  15.561  ? 879  HOH B O     1 ? 
HETATM 10048 O  O     . HOH Y 7 .   ? -20.853 9.017   -79.331  1    44.293  ? 880  HOH B O     1 ? 
HETATM 10049 O  O     . HOH Y 7 .   ? -37.999 -12.913 -78.277  1    50.394  ? 881  HOH B O     1 ? 
HETATM 10050 O  O     . HOH Y 7 .   ? -30.029 -14.684 -88.891  1    40.767  ? 882  HOH B O     1 ? 
HETATM 10051 O  O     . HOH Y 7 .   ? -30.339 -2.813  -68.742  1    56.613  ? 883  HOH B O     1 ? 
HETATM 10052 O  O     . HOH Y 7 .   ? -19.889 -8.839  -90.165  1    43.512  ? 884  HOH B O     1 ? 
HETATM 10053 O  O     . HOH Y 7 .   ? -9.599  -23.04  -54.017  1    50.99   ? 885  HOH B O     1 ? 
HETATM 10054 O  O     . HOH Y 7 .   ? -32.959 -0.589  -50.14   1    42.433  ? 886  HOH B O     1 ? 
HETATM 10055 O  O     . HOH Y 7 .   ? -38.572 12.646  -78.878  1    50.43   ? 887  HOH B O     1 ? 
HETATM 10056 O  O     . HOH Y 7 .   ? -42.321 5.367   -91.432  1    47.78   ? 888  HOH B O     1 ? 
HETATM 10057 O  O     . HOH Y 7 .   ? -39.973 -14.185 -70.461  1    43.172  ? 889  HOH B O     1 ? 
HETATM 10058 O  O     . HOH Y 7 .   ? -34.304 -14.147 -38.156  1    69.027  ? 890  HOH B O     1 ? 
HETATM 10059 O  O     . HOH Y 7 .   ? -36.428 -20.251 -70.623  1    42.779  ? 891  HOH B O     1 ? 
HETATM 10060 O  O     . HOH Y 7 .   ? -8.09   -27.005 -72.18   1    42.098  ? 892  HOH B O     1 ? 
HETATM 10061 O  O     . HOH Y 7 .   ? -15.801 -3.602  -61.997  1    54.35   ? 893  HOH B O     1 ? 
HETATM 10062 O  O     . HOH Y 7 .   ? -34.357 2.694   -72.279  1    40.321  ? 894  HOH B O     1 ? 
HETATM 10063 O  O     . HOH Y 7 .   ? -5.265  -1.581  -52.039  1    62.507  ? 895  HOH B O     1 ? 
HETATM 10064 O  O     . HOH Y 7 .   ? -29.611 12.257  -79.973  1    48.107  ? 896  HOH B O     1 ? 
HETATM 10065 O  O     . HOH Y 7 .   ? -6.919  -19.55  -59.497  1    48.148  ? 897  HOH B O     1 ? 
HETATM 10066 O  O     . HOH Y 7 .   ? -34.645 -5.489  -89.519  1    41.691  ? 898  HOH B O     1 ? 
HETATM 10067 O  O     . HOH Y 7 .   ? -36.715 2.121   -101.731 1    53.558  ? 899  HOH B O     1 ? 
HETATM 10068 O  O     . HOH Y 7 .   ? -29.231 -25.958 -50.287  1    51.673  ? 900  HOH B O     1 ? 
HETATM 10069 O  O     . HOH Y 7 .   ? -25.538 -28.069 -75.588  1    57.097  ? 901  HOH B O     1 ? 
HETATM 10070 O  O     . HOH Y 7 .   ? -32.228 -9.3    -78.526  1    31.779  ? 902  HOH B O     1 ? 
HETATM 10071 O  O     . HOH Y 7 .   ? -20.351 -5.389  -80.008  1    45.275  ? 903  HOH B O     1 ? 
HETATM 10072 O  O     . HOH Y 7 .   ? -17.407 -15.511 -85.436  1    35.419  ? 904  HOH B O     1 ? 
HETATM 10073 O  O     . HOH Y 7 .   ? -11.666 7.868   -73.727  1    54.232  ? 905  HOH B O     1 ? 
HETATM 10074 O  O     . HOH Y 7 .   ? -31.577 -15.277 -68.076  1    43.5    ? 906  HOH B O     1 ? 
HETATM 10075 O  O     . HOH Y 7 .   ? -16.678 -9.414  -84.71   1    32.57   ? 907  HOH B O     1 ? 
HETATM 10076 O  O     . HOH Y 7 .   ? -20.402 2.055   -88.583  1    42.91   ? 908  HOH B O     1 ? 
HETATM 10077 O  O     . HOH Y 7 .   ? -37.804 7.58    -67.945  1    67.841  ? 909  HOH B O     1 ? 
HETATM 10078 O  O     . HOH Y 7 .   ? -14.04  20.942  -75.308  1    52.811  ? 910  HOH B O     1 ? 
HETATM 10079 O  O     . HOH Y 7 .   ? -20.561 1.562   -78.262  1    39.235  ? 911  HOH B O     1 ? 
HETATM 10080 O  O     . HOH Y 7 .   ? -8.649  25.739  -82.793  1    58.365  ? 912  HOH B O     1 ? 
HETATM 10081 O  O     . HOH Y 7 .   ? -25.923 -20.667 -73.397  1    50.787  ? 913  HOH B O     1 ? 
HETATM 10082 O  O     . HOH Y 7 .   ? -41.319 -4.089  -74.565  1    45.639  ? 914  HOH B O     1 ? 
HETATM 10083 O  O     . HOH Y 7 .   ? -5.54   -20.545 -63.267  1    57.062  ? 915  HOH B O     1 ? 
HETATM 10084 O  O     . HOH Y 7 .   ? -34.048 -1.29   -75.864  1    54.378  ? 916  HOH B O     1 ? 
HETATM 10085 O  O     . HOH Y 7 .   ? -31.934 1.554   -96.346  1    53.053  ? 917  HOH B O     1 ? 
HETATM 10086 O  O     . HOH Y 7 .   ? -15.361 -20.788 -58.025  1    38.23   ? 918  HOH B O     1 ? 
HETATM 10087 O  O     . HOH Y 7 .   ? -33.688 -18.427 -79.269  1    39.209  ? 919  HOH B O     1 ? 
HETATM 10088 O  O     . HOH Y 7 .   ? -39.779 -5.45   -88.462  1    48.535  ? 920  HOH B O     1 ? 
HETATM 10089 O  O     . HOH Y 7 .   ? -11.498 9.964   -85.633  1    51.241  ? 921  HOH B O     1 ? 
HETATM 10090 O  O     . HOH Y 7 .   ? -35.709 0.632   -73.771  1    38.194  ? 922  HOH B O     1 ? 
HETATM 10091 O  O     . HOH Y 7 .   ? -12.048 8.651   -81.138  1    45.758  ? 923  HOH B O     1 ? 
HETATM 10092 O  O     . HOH Y 7 .   ? -30.631 -18.727 -76.094  1    48.687  ? 924  HOH B O     1 ? 
HETATM 10093 O  O     . HOH Y 7 .   ? -10.6   6.377   -90.79   1    57.244  ? 925  HOH B O     1 ? 
HETATM 10094 O  O     . HOH Y 7 .   ? -5.272  -27.369 -78.975  1    51.379  ? 926  HOH B O     1 ? 
HETATM 10095 O  O     . HOH Y 7 .   ? -20.839 -6.419  -56.867  1    51.873  ? 927  HOH B O     1 ? 
HETATM 10096 O  O     . HOH Y 7 .   ? -24.357 -18.498 -37.353  1    51.129  ? 928  HOH B O     1 ? 
HETATM 10097 O  O     . HOH Y 7 .   ? -26.058 -10.721 -85.676  1    40.999  ? 929  HOH B O     1 ? 
HETATM 10098 O  O     . HOH Y 7 .   ? -25.144 3.483   -92.378  1    58.53   ? 930  HOH B O     1 ? 
HETATM 10099 O  O     . HOH Y 7 .   ? -26.691 -10.123 -38.188  1    59.106  ? 931  HOH B O     1 ? 
HETATM 10100 O  O     . HOH Y 7 .   ? -3.906  16.381  -76.956  1    51.534  ? 932  HOH B O     1 ? 
HETATM 10101 O  O     . HOH Y 7 .   ? -10.969 9.651   -78.333  1    42.565  ? 933  HOH B O     1 ? 
HETATM 10102 O  O     . HOH Y 7 .   ? -37.52  -5.634  -88.477  1    45.1    ? 934  HOH B O     1 ? 
HETATM 10103 O  O     . HOH Y 7 .   ? -27.517 -3.99   -67.151  1    57.359  ? 935  HOH B O     1 ? 
HETATM 10104 O  O     . HOH Y 7 .   ? -30.367 11.73   -77.687  1    42.513  ? 936  HOH B O     1 ? 
HETATM 10105 O  O     . HOH Y 7 .   ? -28.705 -21.189 -79.817  1    58.894  ? 937  HOH B O     1 ? 
HETATM 10106 O  O     . HOH Y 7 .   ? -19.486 -1.996  -77.018  1    47.795  ? 938  HOH B O     1 ? 
HETATM 10107 O  O     . HOH Y 7 .   ? -11.003 -27.002 -77.56   1    42.789  ? 939  HOH B O     1 ? 
HETATM 10108 O  O     . HOH Y 7 .   ? -15.969 -27.249 -48.505  1    44.655  ? 940  HOH B O     1 ? 
HETATM 10109 O  O     . HOH Y 7 .   ? -24.251 -8.216  -86.039  1    38.44   ? 941  HOH B O     1 ? 
HETATM 10110 O  O     . HOH Y 7 .   ? -23.093 -23.495 -64.01   1    49.616  ? 942  HOH B O     1 ? 
HETATM 10111 O  O     . HOH Y 7 .   ? -9.471  -31.206 -70.349  1    46.448  ? 943  HOH B O     1 ? 
HETATM 10112 O  O     . HOH Y 7 .   ? -18.14  -8.57   -92.355  1    44.717  ? 944  HOH B O     1 ? 
HETATM 10113 O  O     . HOH Y 7 .   ? -12.276 10.6    -83.121  1    41.029  ? 945  HOH B O     1 ? 
HETATM 10114 O  O     . HOH Y 7 .   ? -29.812 -28.75  -74.79   1    58.277  ? 946  HOH B O     1 ? 
HETATM 10115 O  O     . HOH Y 7 .   ? -18.615 -9.208  -42.623  1    54.721  ? 947  HOH B O     1 ? 
HETATM 10116 O  O     . HOH Y 7 .   ? -45.597 10.939  -83.777  1    56.372  ? 948  HOH B O     1 ? 
HETATM 10117 O  O     . HOH Y 7 .   ? -19.677 -13.484 -85.553  1    33.38   ? 949  HOH B O     1 ? 
HETATM 10118 O  O     . HOH Y 7 .   ? -27.988 11.462  -76.952  1    44.132  ? 950  HOH B O     1 ? 
HETATM 10119 O  O     . HOH Y 7 .   ? -18.808 9.877   -72.36   1    48.452  ? 951  HOH B O     1 ? 
HETATM 10120 O  O     . HOH Y 7 .   ? -12.105 -17.446 -91.371  1    60.452  ? 952  HOH B O     1 ? 
HETATM 10121 O  O     . HOH Y 7 .   ? -26.523 -31.314 -46.593  1    39.864  ? 953  HOH B O     1 ? 
HETATM 10122 O  O     . HOH Y 7 .   ? -21.943 -12.312 -38.56   1    55.911  ? 954  HOH B O     1 ? 
HETATM 10123 O  O     . HOH Y 7 .   ? -33.062 -25.245 -40.505  1    50.682  ? 955  HOH B O     1 ? 
HETATM 10124 O  O     . HOH Y 7 .   ? -22.149 -2.679  -75.284  1    47.419  ? 956  HOH B O     1 ? 
HETATM 10125 O  O     . HOH Y 7 .   ? -10.484 0.129   -63.902  1    54.387  ? 957  HOH B O     1 ? 
HETATM 10126 O  O     . HOH Y 7 .   ? -22.458 -4.666  -77.432  1    45.998  ? 958  HOH B O     1 ? 
HETATM 10127 O  O     . HOH Y 7 .   ? -6.176  -26.819 -98.45   1    51.361  ? 959  HOH B O     1 ? 
HETATM 10128 O  O     . HOH Y 7 .   ? -11.209 -25.904 -93.225  1    50.766  ? 960  HOH B O     1 ? 
HETATM 10129 O  O     . HOH Y 7 .   ? -32.403 -28.151 -49.25   1    53.748  ? 961  HOH B O     1 ? 
HETATM 10130 O  O     . HOH Y 7 .   ? -14.593 -16.115 -39.483  1    57.692  ? 962  HOH B O     1 ? 
HETATM 10131 O  O     . HOH Y 7 .   ? -21.494 -27.533 -83.886  1    43.731  ? 963  HOH B O     1 ? 
HETATM 10132 O  O     . HOH Y 7 .   ? -4.156  -20.946 -59.61   1    63.58   ? 964  HOH B O     1 ? 
HETATM 10133 O  O     . HOH Y 7 .   ? -29.238 -13.484 -93.603  1    47.821  ? 965  HOH B O     1 ? 
HETATM 10134 O  O     . HOH Y 7 .   ? -12.384 4.245   -74.4    1    52.296  ? 966  HOH B O     1 ? 
HETATM 10135 O  O     . HOH Y 7 .   ? -12.361 -14.388 -96.116  1    58.783  ? 967  HOH B O     1 ? 
HETATM 10136 O  O     . HOH Y 7 .   ? -27.393 -7.032  -60.334  1    53.072  ? 968  HOH B O     1 ? 
HETATM 10137 O  O     . HOH Y 7 .   ? -19.225 -18.816 -65.961  1    45.479  ? 969  HOH B O     1 ? 
HETATM 10138 O  O     . HOH Y 7 .   ? -25.782 -22.274 -34.538  1    69.21   ? 970  HOH B O     1 ? 
HETATM 10139 O  O     . HOH Y 7 .   ? -1.605  -14.613 -45.726  1    53.216  ? 971  HOH B O     1 ? 
HETATM 10140 O  O     . HOH Y 7 .   ? 3.115   -1.616  -69.312  1    71.821  ? 972  HOH B O     1 ? 
HETATM 10141 O  O     . HOH Y 7 .   ? -21.281 1.987   -75.768  1    45.774  ? 973  HOH B O     1 ? 
HETATM 10142 O  O     . HOH Y 7 .   ? -2.225  -21.152 -63.399  1    53.487  ? 974  HOH B O     1 ? 
HETATM 10143 O  O     . HOH Y 7 .   ? -34.373 -24.587 -76.436  1    64.101  ? 975  HOH B O     1 ? 
HETATM 10144 O  O     . HOH Y 7 .   ? -42.509 -20.348 -55.719  1    48.168  ? 976  HOH B O     1 ? 
HETATM 10145 O  O     . HOH Y 7 .   ? -23.567 -5.43   -61.491  1    62.794  ? 977  HOH B O     1 ? 
HETATM 10146 O  O     . HOH Y 7 .   ? -19.714 -20.623 -66.827  1    51.514  ? 978  HOH B O     1 ? 
HETATM 10147 O  O     . HOH Y 7 .   ? -10.237 -35.776 -65.648  1    57.64   ? 979  HOH B O     1 ? 
HETATM 10148 O  O     . HOH Y 7 .   ? -12.256 -0.336  -93.992  1    53.537  ? 980  HOH B O     1 ? 
HETATM 10149 O  O     . HOH Y 7 .   ? -7.441  3.3     -73.877  1    39.565  ? 981  HOH B O     1 ? 
HETATM 10150 O  O     . HOH Y 7 .   ? -11.377 -6.575  -70.545  1    48.831  ? 982  HOH B O     1 ? 
HETATM 10151 O  O     . HOH Y 7 .   ? 1.786   -16.18  -96.607  1    60.815  ? 983  HOH B O     1 ? 
HETATM 10152 O  O     . HOH Y 7 .   ? -1.079  -30.437 -88.148  1    44.676  ? 984  HOH B O     1 ? 
HETATM 10153 O  O     . HOH Y 7 .   ? -46.748 1.975   -86.679  1    47.739  ? 985  HOH B O     1 ? 
HETATM 10154 O  O     . HOH Y 7 .   ? -19.148 -0.215  -73.371  1    49.81   ? 986  HOH B O     1 ? 
HETATM 10155 O  O     . HOH Y 7 .   ? -7.475  12.897  -73.887  1    62.173  ? 987  HOH B O     1 ? 
HETATM 10156 O  O     . HOH Y 7 .   ? -32.391 -22.582 -73.57   1    63.224  ? 988  HOH B O     1 ? 
HETATM 10157 O  O     . HOH Y 7 .   ? -17.031 2.911   -73.272  1    56.372  ? 989  HOH B O     1 ? 
HETATM 10158 O  O     . HOH Y 7 .   ? -20.402 -3.644  -70.018  1    57.303  ? 990  HOH B O     1 ? 
HETATM 10159 O  O     . HOH Y 7 .   ? -38.441 9.412   -69.814  1    62.757  ? 991  HOH B O     1 ? 
HETATM 10160 O  O     . HOH Y 7 .   ? -22.842 -26.899 -56.2    1    56.701  ? 992  HOH B O     1 ? 
HETATM 10161 O  O     . HOH Y 7 .   ? -23.059 -27.259 -71.436  1    46.298  ? 993  HOH B O     1 ? 
HETATM 10162 O  O     . HOH Y 7 .   ? -15.923 -4.529  -94.417  1    52.396  ? 994  HOH B O     1 ? 
HETATM 10163 O  O     . HOH Y 7 .   ? -2.929  -24.163 -103.259 1    59.956  ? 995  HOH B O     1 ? 
HETATM 10164 O  O     . HOH Y 7 .   ? -38.35  -20.556 -65.963  1    58.733  ? 996  HOH B O     1 ? 
HETATM 10165 O  O     . HOH Y 7 .   ? -18.096 -18.792 -32.587  1    61.409  ? 997  HOH B O     1 ? 
HETATM 10166 O  O     . HOH Y 7 .   ? -13.3   12.88   -80.279  1    60.38   ? 998  HOH B O     1 ? 
HETATM 10167 O  O     . HOH Y 7 .   ? -12.541 -2.864  -69.952  1    49.098  ? 999  HOH B O     1 ? 
HETATM 10168 O  O     . HOH Y 7 .   ? -0.29   -8.353  -46.73   1    63.858  ? 1000 HOH B O     1 ? 
HETATM 10169 O  O     . HOH Y 7 .   ? -39.575 -14.451 -43.616  1    71.35   ? 1001 HOH B O     1 ? 
HETATM 10170 O  O     . HOH Y 7 .   ? -45.609 2.384   -89.16   1    53.508  ? 1002 HOH B O     1 ? 
HETATM 10171 O  O     . HOH Y 7 .   ? -38.838 13.504  -44.96   1    61.897  ? 1003 HOH B O     1 ? 
HETATM 10172 O  O     . HOH Y 7 .   ? 1.348   -23.901 -78.314  1    55.927  ? 1004 HOH B O     1 ? 
HETATM 10173 O  O     . HOH Y 7 .   ? -19.989 7.844   -87.518  1    43.283  ? 1005 HOH B O     1 ? 
HETATM 10174 O  O     . HOH Y 7 .   ? -36.477 14.902  -82.126  1    47.31   ? 1006 HOH B O     1 ? 
HETATM 10175 O  O     . HOH Y 7 .   ? -33.174 14.353  -82.968  1    50.569  ? 1007 HOH B O     1 ? 
HETATM 10176 O  O     . HOH Y 7 .   ? -8.249  -28.355 -74.456  1    37.264  ? 1008 HOH B O     1 ? 
HETATM 10177 O  O     . HOH Y 7 .   ? -3.353  -21.493 -103.728 1    51.612  ? 1009 HOH B O     1 ? 
HETATM 10178 O  O     . HOH Y 7 .   ? -28.751 -17.7   -80.285  1    50.453  ? 1010 HOH B O     1 ? 
# 
