data_9E1T
# 
_entry.id   9E1T 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9E1T         pdb_00009e1t 10.2210/pdb9e1t/pdb 
WWPDB D_1000289128 ?            ?                   
EMDB  EMD-47420    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'EM metadata'     1 0 2025-02-12 ? 
3 'Additional map'  1 0 2025-02-12 ? 
4 'Half map'        1 0 2025-02-12 1 
5 'Half map'        1 0 2025-02-12 2 
6 Image             1 0 2025-02-12 ? 
7 'Primary map'     1 0 2025-02-12 ? 
8 'Structure model' 1 1 2025-05-21 ? 
9 'EM metadata'     1 1 2025-05-21 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'      
2 9 'EM metadata'     'Data processing'      
3 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' em_admin    
2 8 'Structure model' em_software 
3 9 'EM metadata'     em_admin    
4 9 'EM metadata'     em_software 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 8 'Structure model' '_em_admin.last_update' 
2 8 'Structure model' '_em_software.name'     
3 9 'EM metadata'     '_em_admin.last_update' 
4 9 'EM metadata'     '_em_software.name'     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9E1T 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'CryoEM structure of LARGE1 bound to UDP' 
_pdbx_database_related.db_id          EMD-47420 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              kevin-campbell@uiowa.edu 
_pdbx_contact_author.name_first         Kevin 
_pdbx_contact_author.name_last          Campbell 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2066-5889 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Joesph, S.'     1 ? 
'Spellmon, N.'   2 ? 
'Campbell, K.P.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Prodystroglycan defines matriglycan lengths processively polymerized by LARGE1' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Joesph, S.'       1  ? 
primary 'Spellmon, N.'     2  ? 
primary 'Schnicker, N.J.'  3  ? 
primary 'Xu, Z.'           4  ? 
primary 'Yang, T.'         5  ? 
primary 'Hopkins, J.'      6  ? 
primary 'Chakravarthy, S.' 7  ? 
primary 'Davulcu, O.'      8  ? 
primary 'Anderson, M.E.'   9  ? 
primary 'Venzke, D.'       10 ? 
primary 'Campbell, K.P.'   11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Xylosyl- and glucuronyltransferase LARGE1' 89806.242 2 2.4.-.-,2.4.2.-,2.4.1.- ? ? ? 
2 non-polymer syn 'MANGANESE (II) ION'                        54.938    2 ?                       ? ? ? 
3 non-polymer syn "URIDINE-5'-DIPHOSPHATE"                    404.161   2 ?                       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Acetylglucosaminyltransferase-like 1A,Glycosyltransferase-like protein,LARGE xylosyl- and glucuronyltransferase 1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSALLILALVGAAVADYKDHDGDYKDHDIDYKDDDDKLAAAFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREV
EEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRD
VVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLP
ANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKW
EQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNK
HVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADST
DVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMK
HISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTK
GHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSF
DITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSALLILALVGAAVADYKDHDGDYKDHDIDYKDDDDKLAAAFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREV
EEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRD
VVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLP
ANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKW
EQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNK
HVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADST
DVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMK
HISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTK
GHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSF
DITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNSHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'MANGANESE (II) ION'     MN  
3 "URIDINE-5'-DIPHOSPHATE" UDP 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   ALA n 
1 4   LEU n 
1 5   LEU n 
1 6   ILE n 
1 7   LEU n 
1 8   ALA n 
1 9   LEU n 
1 10  VAL n 
1 11  GLY n 
1 12  ALA n 
1 13  ALA n 
1 14  VAL n 
1 15  ALA n 
1 16  ASP n 
1 17  TYR n 
1 18  LYS n 
1 19  ASP n 
1 20  HIS n 
1 21  ASP n 
1 22  GLY n 
1 23  ASP n 
1 24  TYR n 
1 25  LYS n 
1 26  ASP n 
1 27  HIS n 
1 28  ASP n 
1 29  ILE n 
1 30  ASP n 
1 31  TYR n 
1 32  LYS n 
1 33  ASP n 
1 34  ASP n 
1 35  ASP n 
1 36  ASP n 
1 37  LYS n 
1 38  LEU n 
1 39  ALA n 
1 40  ALA n 
1 41  ALA n 
1 42  PHE n 
1 43  GLU n 
1 44  ASP n 
1 45  GLY n 
1 46  LYS n 
1 47  PRO n 
1 48  VAL n 
1 49  SER n 
1 50  LEU n 
1 51  SER n 
1 52  PRO n 
1 53  LEU n 
1 54  GLU n 
1 55  SER n 
1 56  GLN n 
1 57  ALA n 
1 58  HIS n 
1 59  SER n 
1 60  PRO n 
1 61  ARG n 
1 62  TYR n 
1 63  THR n 
1 64  ALA n 
1 65  SER n 
1 66  SER n 
1 67  GLN n 
1 68  ARG n 
1 69  GLU n 
1 70  ARG n 
1 71  GLU n 
1 72  SER n 
1 73  LEU n 
1 74  GLU n 
1 75  VAL n 
1 76  ARG n 
1 77  MET n 
1 78  ARG n 
1 79  GLU n 
1 80  VAL n 
1 81  GLU n 
1 82  GLU n 
1 83  GLU n 
1 84  ASN n 
1 85  ARG n 
1 86  ALA n 
1 87  LEU n 
1 88  ARG n 
1 89  ARG n 
1 90  GLN n 
1 91  LEU n 
1 92  SER n 
1 93  LEU n 
1 94  ALA n 
1 95  GLN n 
1 96  GLY n 
1 97  ARG n 
1 98  ALA n 
1 99  PRO n 
1 100 SER n 
1 101 HIS n 
1 102 ARG n 
1 103 ARG n 
1 104 GLY n 
1 105 ASN n 
1 106 HIS n 
1 107 SER n 
1 108 LYS n 
1 109 THR n 
1 110 TYR n 
1 111 SER n 
1 112 MET n 
1 113 GLU n 
1 114 GLU n 
1 115 GLY n 
1 116 THR n 
1 117 GLY n 
1 118 ASP n 
1 119 SER n 
1 120 GLU n 
1 121 ASN n 
1 122 LEU n 
1 123 ARG n 
1 124 ALA n 
1 125 GLY n 
1 126 ILE n 
1 127 VAL n 
1 128 ALA n 
1 129 GLY n 
1 130 ASN n 
1 131 SER n 
1 132 SER n 
1 133 GLU n 
1 134 CYS n 
1 135 GLY n 
1 136 GLN n 
1 137 GLN n 
1 138 PRO n 
1 139 VAL n 
1 140 VAL n 
1 141 GLU n 
1 142 LYS n 
1 143 CYS n 
1 144 GLU n 
1 145 THR n 
1 146 ILE n 
1 147 HIS n 
1 148 VAL n 
1 149 ALA n 
1 150 ILE n 
1 151 VAL n 
1 152 CYS n 
1 153 ALA n 
1 154 GLY n 
1 155 TYR n 
1 156 ASN n 
1 157 ALA n 
1 158 SER n 
1 159 ARG n 
1 160 ASP n 
1 161 VAL n 
1 162 VAL n 
1 163 THR n 
1 164 LEU n 
1 165 VAL n 
1 166 LYS n 
1 167 SER n 
1 168 VAL n 
1 169 LEU n 
1 170 PHE n 
1 171 HIS n 
1 172 ARG n 
1 173 ARG n 
1 174 ASN n 
1 175 PRO n 
1 176 LEU n 
1 177 HIS n 
1 178 PHE n 
1 179 HIS n 
1 180 LEU n 
1 181 ILE n 
1 182 ALA n 
1 183 ASP n 
1 184 SER n 
1 185 ILE n 
1 186 ALA n 
1 187 GLU n 
1 188 GLN n 
1 189 ILE n 
1 190 LEU n 
1 191 ALA n 
1 192 THR n 
1 193 LEU n 
1 194 PHE n 
1 195 GLN n 
1 196 THR n 
1 197 TRP n 
1 198 MET n 
1 199 VAL n 
1 200 PRO n 
1 201 ALA n 
1 202 VAL n 
1 203 ARG n 
1 204 VAL n 
1 205 ASP n 
1 206 PHE n 
1 207 TYR n 
1 208 ASN n 
1 209 ALA n 
1 210 ASP n 
1 211 GLU n 
1 212 LEU n 
1 213 LYS n 
1 214 SER n 
1 215 GLU n 
1 216 VAL n 
1 217 SER n 
1 218 TRP n 
1 219 ILE n 
1 220 PRO n 
1 221 ASN n 
1 222 LYS n 
1 223 HIS n 
1 224 TYR n 
1 225 SER n 
1 226 GLY n 
1 227 ILE n 
1 228 TYR n 
1 229 GLY n 
1 230 LEU n 
1 231 MET n 
1 232 LYS n 
1 233 LEU n 
1 234 VAL n 
1 235 LEU n 
1 236 THR n 
1 237 LYS n 
1 238 THR n 
1 239 LEU n 
1 240 PRO n 
1 241 ALA n 
1 242 ASN n 
1 243 LEU n 
1 244 GLU n 
1 245 ARG n 
1 246 VAL n 
1 247 ILE n 
1 248 VAL n 
1 249 LEU n 
1 250 ASP n 
1 251 THR n 
1 252 ASP n 
1 253 ILE n 
1 254 THR n 
1 255 PHE n 
1 256 ALA n 
1 257 THR n 
1 258 ASP n 
1 259 ILE n 
1 260 ALA n 
1 261 GLU n 
1 262 LEU n 
1 263 TRP n 
1 264 ALA n 
1 265 VAL n 
1 266 PHE n 
1 267 HIS n 
1 268 LYS n 
1 269 PHE n 
1 270 LYS n 
1 271 GLY n 
1 272 GLN n 
1 273 GLN n 
1 274 VAL n 
1 275 LEU n 
1 276 GLY n 
1 277 LEU n 
1 278 VAL n 
1 279 GLU n 
1 280 ASN n 
1 281 GLN n 
1 282 SER n 
1 283 ASP n 
1 284 TRP n 
1 285 TYR n 
1 286 LEU n 
1 287 GLY n 
1 288 ASN n 
1 289 LEU n 
1 290 TRP n 
1 291 LYS n 
1 292 ASN n 
1 293 HIS n 
1 294 ARG n 
1 295 PRO n 
1 296 TRP n 
1 297 PRO n 
1 298 ALA n 
1 299 LEU n 
1 300 GLY n 
1 301 ARG n 
1 302 GLY n 
1 303 TYR n 
1 304 ASN n 
1 305 THR n 
1 306 GLY n 
1 307 VAL n 
1 308 ILE n 
1 309 LEU n 
1 310 LEU n 
1 311 LEU n 
1 312 LEU n 
1 313 ASP n 
1 314 LYS n 
1 315 LEU n 
1 316 ARG n 
1 317 LYS n 
1 318 MET n 
1 319 LYS n 
1 320 TRP n 
1 321 GLU n 
1 322 GLN n 
1 323 MET n 
1 324 TRP n 
1 325 ARG n 
1 326 LEU n 
1 327 THR n 
1 328 ALA n 
1 329 GLU n 
1 330 ARG n 
1 331 GLU n 
1 332 LEU n 
1 333 MET n 
1 334 GLY n 
1 335 MET n 
1 336 LEU n 
1 337 SER n 
1 338 THR n 
1 339 SER n 
1 340 LEU n 
1 341 ALA n 
1 342 ASP n 
1 343 GLN n 
1 344 ASP n 
1 345 ILE n 
1 346 PHE n 
1 347 ASN n 
1 348 ALA n 
1 349 VAL n 
1 350 ILE n 
1 351 LYS n 
1 352 GLN n 
1 353 ASN n 
1 354 PRO n 
1 355 PHE n 
1 356 LEU n 
1 357 VAL n 
1 358 TYR n 
1 359 GLN n 
1 360 LEU n 
1 361 PRO n 
1 362 CYS n 
1 363 PHE n 
1 364 TRP n 
1 365 ASN n 
1 366 VAL n 
1 367 GLN n 
1 368 LEU n 
1 369 SER n 
1 370 ASP n 
1 371 HIS n 
1 372 THR n 
1 373 ARG n 
1 374 SER n 
1 375 GLU n 
1 376 GLN n 
1 377 CYS n 
1 378 TYR n 
1 379 ARG n 
1 380 ASP n 
1 381 VAL n 
1 382 SER n 
1 383 ASP n 
1 384 LEU n 
1 385 LYS n 
1 386 VAL n 
1 387 ILE n 
1 388 HIS n 
1 389 TRP n 
1 390 ASN n 
1 391 SER n 
1 392 PRO n 
1 393 LYS n 
1 394 LYS n 
1 395 LEU n 
1 396 ARG n 
1 397 VAL n 
1 398 LYS n 
1 399 ASN n 
1 400 LYS n 
1 401 HIS n 
1 402 VAL n 
1 403 GLU n 
1 404 PHE n 
1 405 PHE n 
1 406 ARG n 
1 407 ASN n 
1 408 LEU n 
1 409 TYR n 
1 410 LEU n 
1 411 THR n 
1 412 PHE n 
1 413 LEU n 
1 414 GLU n 
1 415 TYR n 
1 416 ASP n 
1 417 GLY n 
1 418 ASN n 
1 419 LEU n 
1 420 LEU n 
1 421 ARG n 
1 422 ARG n 
1 423 GLU n 
1 424 LEU n 
1 425 PHE n 
1 426 GLY n 
1 427 CYS n 
1 428 PRO n 
1 429 SER n 
1 430 GLU n 
1 431 ALA n 
1 432 ASP n 
1 433 VAL n 
1 434 ASN n 
1 435 SER n 
1 436 GLU n 
1 437 ASN n 
1 438 LEU n 
1 439 GLN n 
1 440 LYS n 
1 441 GLN n 
1 442 LEU n 
1 443 SER n 
1 444 GLU n 
1 445 LEU n 
1 446 ASP n 
1 447 GLU n 
1 448 ASP n 
1 449 ASP n 
1 450 LEU n 
1 451 CYS n 
1 452 TYR n 
1 453 GLU n 
1 454 PHE n 
1 455 ARG n 
1 456 ARG n 
1 457 GLU n 
1 458 ARG n 
1 459 PHE n 
1 460 THR n 
1 461 VAL n 
1 462 HIS n 
1 463 ARG n 
1 464 THR n 
1 465 HIS n 
1 466 LEU n 
1 467 TYR n 
1 468 PHE n 
1 469 LEU n 
1 470 HIS n 
1 471 TYR n 
1 472 GLU n 
1 473 TYR n 
1 474 GLU n 
1 475 PRO n 
1 476 ALA n 
1 477 ALA n 
1 478 ASP n 
1 479 SER n 
1 480 THR n 
1 481 ASP n 
1 482 VAL n 
1 483 THR n 
1 484 LEU n 
1 485 VAL n 
1 486 ALA n 
1 487 GLN n 
1 488 LEU n 
1 489 SER n 
1 490 MET n 
1 491 ASP n 
1 492 ARG n 
1 493 LEU n 
1 494 GLN n 
1 495 MET n 
1 496 LEU n 
1 497 GLU n 
1 498 ALA n 
1 499 ILE n 
1 500 CYS n 
1 501 LYS n 
1 502 HIS n 
1 503 TRP n 
1 504 GLU n 
1 505 GLY n 
1 506 PRO n 
1 507 ILE n 
1 508 SER n 
1 509 LEU n 
1 510 ALA n 
1 511 LEU n 
1 512 TYR n 
1 513 LEU n 
1 514 SER n 
1 515 ASP n 
1 516 ALA n 
1 517 GLU n 
1 518 ALA n 
1 519 GLN n 
1 520 GLN n 
1 521 PHE n 
1 522 LEU n 
1 523 ARG n 
1 524 TYR n 
1 525 ALA n 
1 526 GLN n 
1 527 GLY n 
1 528 SER n 
1 529 GLU n 
1 530 VAL n 
1 531 LEU n 
1 532 MET n 
1 533 SER n 
1 534 ARG n 
1 535 HIS n 
1 536 ASN n 
1 537 VAL n 
1 538 GLY n 
1 539 TYR n 
1 540 HIS n 
1 541 ILE n 
1 542 VAL n 
1 543 TYR n 
1 544 LYS n 
1 545 GLU n 
1 546 GLY n 
1 547 GLN n 
1 548 PHE n 
1 549 TYR n 
1 550 PRO n 
1 551 VAL n 
1 552 ASN n 
1 553 LEU n 
1 554 LEU n 
1 555 ARG n 
1 556 ASN n 
1 557 VAL n 
1 558 ALA n 
1 559 MET n 
1 560 LYS n 
1 561 HIS n 
1 562 ILE n 
1 563 SER n 
1 564 THR n 
1 565 PRO n 
1 566 TYR n 
1 567 MET n 
1 568 PHE n 
1 569 LEU n 
1 570 SER n 
1 571 ASP n 
1 572 ILE n 
1 573 ASP n 
1 574 PHE n 
1 575 LEU n 
1 576 PRO n 
1 577 MET n 
1 578 TYR n 
1 579 GLY n 
1 580 LEU n 
1 581 TYR n 
1 582 GLU n 
1 583 TYR n 
1 584 LEU n 
1 585 ARG n 
1 586 LYS n 
1 587 SER n 
1 588 VAL n 
1 589 ILE n 
1 590 GLN n 
1 591 LEU n 
1 592 ASP n 
1 593 LEU n 
1 594 ALA n 
1 595 ASN n 
1 596 THR n 
1 597 LYS n 
1 598 LYS n 
1 599 ALA n 
1 600 MET n 
1 601 ILE n 
1 602 VAL n 
1 603 PRO n 
1 604 ALA n 
1 605 PHE n 
1 606 GLU n 
1 607 THR n 
1 608 LEU n 
1 609 ARG n 
1 610 TYR n 
1 611 ARG n 
1 612 LEU n 
1 613 SER n 
1 614 PHE n 
1 615 PRO n 
1 616 LYS n 
1 617 SER n 
1 618 LYS n 
1 619 ALA n 
1 620 GLU n 
1 621 LEU n 
1 622 LEU n 
1 623 SER n 
1 624 MET n 
1 625 LEU n 
1 626 ASP n 
1 627 MET n 
1 628 GLY n 
1 629 THR n 
1 630 LEU n 
1 631 PHE n 
1 632 THR n 
1 633 PHE n 
1 634 ARG n 
1 635 TYR n 
1 636 HIS n 
1 637 VAL n 
1 638 TRP n 
1 639 THR n 
1 640 LYS n 
1 641 GLY n 
1 642 HIS n 
1 643 ALA n 
1 644 PRO n 
1 645 THR n 
1 646 ASN n 
1 647 PHE n 
1 648 ALA n 
1 649 LYS n 
1 650 TRP n 
1 651 ARG n 
1 652 THR n 
1 653 ALA n 
1 654 THR n 
1 655 THR n 
1 656 PRO n 
1 657 TYR n 
1 658 ARG n 
1 659 VAL n 
1 660 GLU n 
1 661 TRP n 
1 662 GLU n 
1 663 ALA n 
1 664 ASP n 
1 665 PHE n 
1 666 GLU n 
1 667 PRO n 
1 668 TYR n 
1 669 VAL n 
1 670 VAL n 
1 671 VAL n 
1 672 ARG n 
1 673 ARG n 
1 674 ASP n 
1 675 CYS n 
1 676 PRO n 
1 677 GLU n 
1 678 TYR n 
1 679 ASP n 
1 680 ARG n 
1 681 ARG n 
1 682 PHE n 
1 683 VAL n 
1 684 GLY n 
1 685 PHE n 
1 686 GLY n 
1 687 TRP n 
1 688 ASN n 
1 689 LYS n 
1 690 VAL n 
1 691 ALA n 
1 692 HIS n 
1 693 ILE n 
1 694 MET n 
1 695 GLU n 
1 696 LEU n 
1 697 ASP n 
1 698 VAL n 
1 699 GLN n 
1 700 GLU n 
1 701 TYR n 
1 702 GLU n 
1 703 PHE n 
1 704 ILE n 
1 705 VAL n 
1 706 LEU n 
1 707 PRO n 
1 708 ASN n 
1 709 ALA n 
1 710 TYR n 
1 711 MET n 
1 712 ILE n 
1 713 HIS n 
1 714 MET n 
1 715 PRO n 
1 716 HIS n 
1 717 ALA n 
1 718 PRO n 
1 719 SER n 
1 720 PHE n 
1 721 ASP n 
1 722 ILE n 
1 723 THR n 
1 724 LYS n 
1 725 PHE n 
1 726 ARG n 
1 727 SER n 
1 728 ASN n 
1 729 LYS n 
1 730 GLN n 
1 731 TYR n 
1 732 ARG n 
1 733 ILE n 
1 734 CYS n 
1 735 LEU n 
1 736 LYS n 
1 737 THR n 
1 738 LEU n 
1 739 LYS n 
1 740 GLU n 
1 741 GLU n 
1 742 PHE n 
1 743 GLN n 
1 744 GLN n 
1 745 ASP n 
1 746 MET n 
1 747 SER n 
1 748 ARG n 
1 749 ARG n 
1 750 TYR n 
1 751 GLY n 
1 752 PHE n 
1 753 ALA n 
1 754 ALA n 
1 755 LEU n 
1 756 LYS n 
1 757 TYR n 
1 758 LEU n 
1 759 THR n 
1 760 ALA n 
1 761 GLU n 
1 762 ASN n 
1 763 ASN n 
1 764 SER n 
1 765 HIS n 
1 766 HIS n 
1 767 HIS n 
1 768 HIS n 
1 769 HIS n 
1 770 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   770 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'LARGE1, KIAA0609, LARGE' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                  ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                 ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE               ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'          ? 'C4 H7 N O4'       133.103 
CYS 'L-peptide linking' y CYSTEINE                 ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE                ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'          ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                  ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE                ? 'C6 H10 N3 O2 1'   156.162 
ILE 'L-peptide linking' y ISOLEUCINE               ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                  ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                   ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE               ? 'C5 H11 N O2 S'    149.211 
MN  non-polymer         . 'MANGANESE (II) ION'     ? 'Mn 2'             54.938  
PHE 'L-peptide linking' y PHENYLALANINE            ? 'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE                  ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                   ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN               ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                 ? 'C9 H11 N O3'      181.189 
UDP 'RNA linking'       . "URIDINE-5'-DIPHOSPHATE" ? 'C9 H14 N2 O12 P2' 404.161 
VAL 'L-peptide linking' y VALINE                   ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -7  ?   ?   ?   A . n 
A 1 2   SER 2   -6  ?   ?   ?   A . n 
A 1 3   ALA 3   -5  ?   ?   ?   A . n 
A 1 4   LEU 4   -4  ?   ?   ?   A . n 
A 1 5   LEU 5   -3  ?   ?   ?   A . n 
A 1 6   ILE 6   -2  ?   ?   ?   A . n 
A 1 7   LEU 7   -1  ?   ?   ?   A . n 
A 1 8   ALA 8   0   ?   ?   ?   A . n 
A 1 9   LEU 9   1   ?   ?   ?   A . n 
A 1 10  VAL 10  2   ?   ?   ?   A . n 
A 1 11  GLY 11  3   ?   ?   ?   A . n 
A 1 12  ALA 12  4   ?   ?   ?   A . n 
A 1 13  ALA 13  5   ?   ?   ?   A . n 
A 1 14  VAL 14  6   ?   ?   ?   A . n 
A 1 15  ALA 15  7   ?   ?   ?   A . n 
A 1 16  ASP 16  8   ?   ?   ?   A . n 
A 1 17  TYR 17  9   ?   ?   ?   A . n 
A 1 18  LYS 18  10  ?   ?   ?   A . n 
A 1 19  ASP 19  11  ?   ?   ?   A . n 
A 1 20  HIS 20  12  ?   ?   ?   A . n 
A 1 21  ASP 21  13  ?   ?   ?   A . n 
A 1 22  GLY 22  14  ?   ?   ?   A . n 
A 1 23  ASP 23  15  ?   ?   ?   A . n 
A 1 24  TYR 24  16  ?   ?   ?   A . n 
A 1 25  LYS 25  17  ?   ?   ?   A . n 
A 1 26  ASP 26  18  ?   ?   ?   A . n 
A 1 27  HIS 27  19  ?   ?   ?   A . n 
A 1 28  ASP 28  20  ?   ?   ?   A . n 
A 1 29  ILE 29  21  ?   ?   ?   A . n 
A 1 30  ASP 30  22  ?   ?   ?   A . n 
A 1 31  TYR 31  23  ?   ?   ?   A . n 
A 1 32  LYS 32  24  ?   ?   ?   A . n 
A 1 33  ASP 33  25  ?   ?   ?   A . n 
A 1 34  ASP 34  26  ?   ?   ?   A . n 
A 1 35  ASP 35  27  ?   ?   ?   A . n 
A 1 36  ASP 36  28  ?   ?   ?   A . n 
A 1 37  LYS 37  29  ?   ?   ?   A . n 
A 1 38  LEU 38  30  ?   ?   ?   A . n 
A 1 39  ALA 39  31  ?   ?   ?   A . n 
A 1 40  ALA 40  32  ?   ?   ?   A . n 
A 1 41  ALA 41  33  ?   ?   ?   A . n 
A 1 42  PHE 42  34  ?   ?   ?   A . n 
A 1 43  GLU 43  35  ?   ?   ?   A . n 
A 1 44  ASP 44  36  ?   ?   ?   A . n 
A 1 45  GLY 45  37  ?   ?   ?   A . n 
A 1 46  LYS 46  38  ?   ?   ?   A . n 
A 1 47  PRO 47  39  ?   ?   ?   A . n 
A 1 48  VAL 48  40  ?   ?   ?   A . n 
A 1 49  SER 49  41  ?   ?   ?   A . n 
A 1 50  LEU 50  42  ?   ?   ?   A . n 
A 1 51  SER 51  43  ?   ?   ?   A . n 
A 1 52  PRO 52  44  ?   ?   ?   A . n 
A 1 53  LEU 53  45  ?   ?   ?   A . n 
A 1 54  GLU 54  46  ?   ?   ?   A . n 
A 1 55  SER 55  47  ?   ?   ?   A . n 
A 1 56  GLN 56  48  ?   ?   ?   A . n 
A 1 57  ALA 57  49  ?   ?   ?   A . n 
A 1 58  HIS 58  50  ?   ?   ?   A . n 
A 1 59  SER 59  51  ?   ?   ?   A . n 
A 1 60  PRO 60  52  ?   ?   ?   A . n 
A 1 61  ARG 61  53  ?   ?   ?   A . n 
A 1 62  TYR 62  54  ?   ?   ?   A . n 
A 1 63  THR 63  55  ?   ?   ?   A . n 
A 1 64  ALA 64  56  ?   ?   ?   A . n 
A 1 65  SER 65  57  ?   ?   ?   A . n 
A 1 66  SER 66  58  ?   ?   ?   A . n 
A 1 67  GLN 67  59  ?   ?   ?   A . n 
A 1 68  ARG 68  60  ?   ?   ?   A . n 
A 1 69  GLU 69  61  ?   ?   ?   A . n 
A 1 70  ARG 70  62  ?   ?   ?   A . n 
A 1 71  GLU 71  63  ?   ?   ?   A . n 
A 1 72  SER 72  64  ?   ?   ?   A . n 
A 1 73  LEU 73  65  ?   ?   ?   A . n 
A 1 74  GLU 74  66  ?   ?   ?   A . n 
A 1 75  VAL 75  67  ?   ?   ?   A . n 
A 1 76  ARG 76  68  ?   ?   ?   A . n 
A 1 77  MET 77  69  ?   ?   ?   A . n 
A 1 78  ARG 78  70  ?   ?   ?   A . n 
A 1 79  GLU 79  71  ?   ?   ?   A . n 
A 1 80  VAL 80  72  ?   ?   ?   A . n 
A 1 81  GLU 81  73  ?   ?   ?   A . n 
A 1 82  GLU 82  74  ?   ?   ?   A . n 
A 1 83  GLU 83  75  ?   ?   ?   A . n 
A 1 84  ASN 84  76  ?   ?   ?   A . n 
A 1 85  ARG 85  77  ?   ?   ?   A . n 
A 1 86  ALA 86  78  ?   ?   ?   A . n 
A 1 87  LEU 87  79  ?   ?   ?   A . n 
A 1 88  ARG 88  80  ?   ?   ?   A . n 
A 1 89  ARG 89  81  ?   ?   ?   A . n 
A 1 90  GLN 90  82  ?   ?   ?   A . n 
A 1 91  LEU 91  83  ?   ?   ?   A . n 
A 1 92  SER 92  84  ?   ?   ?   A . n 
A 1 93  LEU 93  85  ?   ?   ?   A . n 
A 1 94  ALA 94  86  ?   ?   ?   A . n 
A 1 95  GLN 95  87  ?   ?   ?   A . n 
A 1 96  GLY 96  88  ?   ?   ?   A . n 
A 1 97  ARG 97  89  ?   ?   ?   A . n 
A 1 98  ALA 98  90  ?   ?   ?   A . n 
A 1 99  PRO 99  91  ?   ?   ?   A . n 
A 1 100 SER 100 92  ?   ?   ?   A . n 
A 1 101 HIS 101 93  ?   ?   ?   A . n 
A 1 102 ARG 102 94  ?   ?   ?   A . n 
A 1 103 ARG 103 95  ?   ?   ?   A . n 
A 1 104 GLY 104 96  ?   ?   ?   A . n 
A 1 105 ASN 105 97  ?   ?   ?   A . n 
A 1 106 HIS 106 98  ?   ?   ?   A . n 
A 1 107 SER 107 99  ?   ?   ?   A . n 
A 1 108 LYS 108 100 ?   ?   ?   A . n 
A 1 109 THR 109 101 ?   ?   ?   A . n 
A 1 110 TYR 110 102 ?   ?   ?   A . n 
A 1 111 SER 111 103 ?   ?   ?   A . n 
A 1 112 MET 112 104 ?   ?   ?   A . n 
A 1 113 GLU 113 105 ?   ?   ?   A . n 
A 1 114 GLU 114 106 ?   ?   ?   A . n 
A 1 115 GLY 115 107 ?   ?   ?   A . n 
A 1 116 THR 116 108 ?   ?   ?   A . n 
A 1 117 GLY 117 109 ?   ?   ?   A . n 
A 1 118 ASP 118 110 ?   ?   ?   A . n 
A 1 119 SER 119 111 ?   ?   ?   A . n 
A 1 120 GLU 120 112 ?   ?   ?   A . n 
A 1 121 ASN 121 113 ?   ?   ?   A . n 
A 1 122 LEU 122 114 ?   ?   ?   A . n 
A 1 123 ARG 123 115 ?   ?   ?   A . n 
A 1 124 ALA 124 116 ?   ?   ?   A . n 
A 1 125 GLY 125 117 ?   ?   ?   A . n 
A 1 126 ILE 126 118 ?   ?   ?   A . n 
A 1 127 VAL 127 119 ?   ?   ?   A . n 
A 1 128 ALA 128 120 ?   ?   ?   A . n 
A 1 129 GLY 129 121 ?   ?   ?   A . n 
A 1 130 ASN 130 122 ?   ?   ?   A . n 
A 1 131 SER 131 123 ?   ?   ?   A . n 
A 1 132 SER 132 124 ?   ?   ?   A . n 
A 1 133 GLU 133 125 ?   ?   ?   A . n 
A 1 134 CYS 134 126 ?   ?   ?   A . n 
A 1 135 GLY 135 127 ?   ?   ?   A . n 
A 1 136 GLN 136 128 ?   ?   ?   A . n 
A 1 137 GLN 137 129 ?   ?   ?   A . n 
A 1 138 PRO 138 130 ?   ?   ?   A . n 
A 1 139 VAL 139 131 ?   ?   ?   A . n 
A 1 140 VAL 140 132 ?   ?   ?   A . n 
A 1 141 GLU 141 133 ?   ?   ?   A . n 
A 1 142 LYS 142 134 134 LYS LYS A . n 
A 1 143 CYS 143 135 135 CYS CYS A . n 
A 1 144 GLU 144 136 136 GLU GLU A . n 
A 1 145 THR 145 137 137 THR THR A . n 
A 1 146 ILE 146 138 138 ILE ILE A . n 
A 1 147 HIS 147 139 139 HIS HIS A . n 
A 1 148 VAL 148 140 140 VAL VAL A . n 
A 1 149 ALA 149 141 141 ALA ALA A . n 
A 1 150 ILE 150 142 142 ILE ILE A . n 
A 1 151 VAL 151 143 143 VAL VAL A . n 
A 1 152 CYS 152 144 144 CYS CYS A . n 
A 1 153 ALA 153 145 145 ALA ALA A . n 
A 1 154 GLY 154 146 146 GLY GLY A . n 
A 1 155 TYR 155 147 147 TYR TYR A . n 
A 1 156 ASN 156 148 148 ASN ASN A . n 
A 1 157 ALA 157 149 149 ALA ALA A . n 
A 1 158 SER 158 150 150 SER SER A . n 
A 1 159 ARG 159 151 151 ARG ARG A . n 
A 1 160 ASP 160 152 152 ASP ASP A . n 
A 1 161 VAL 161 153 153 VAL VAL A . n 
A 1 162 VAL 162 154 154 VAL VAL A . n 
A 1 163 THR 163 155 155 THR THR A . n 
A 1 164 LEU 164 156 156 LEU LEU A . n 
A 1 165 VAL 165 157 157 VAL VAL A . n 
A 1 166 LYS 166 158 158 LYS LYS A . n 
A 1 167 SER 167 159 159 SER SER A . n 
A 1 168 VAL 168 160 160 VAL VAL A . n 
A 1 169 LEU 169 161 161 LEU LEU A . n 
A 1 170 PHE 170 162 162 PHE PHE A . n 
A 1 171 HIS 171 163 163 HIS HIS A . n 
A 1 172 ARG 172 164 164 ARG ARG A . n 
A 1 173 ARG 173 165 165 ARG ARG A . n 
A 1 174 ASN 174 166 166 ASN ASN A . n 
A 1 175 PRO 175 167 167 PRO PRO A . n 
A 1 176 LEU 176 168 168 LEU LEU A . n 
A 1 177 HIS 177 169 169 HIS HIS A . n 
A 1 178 PHE 178 170 170 PHE PHE A . n 
A 1 179 HIS 179 171 171 HIS HIS A . n 
A 1 180 LEU 180 172 172 LEU LEU A . n 
A 1 181 ILE 181 173 173 ILE ILE A . n 
A 1 182 ALA 182 174 174 ALA ALA A . n 
A 1 183 ASP 183 175 175 ASP ASP A . n 
A 1 184 SER 184 176 176 SER SER A . n 
A 1 185 ILE 185 177 177 ILE ILE A . n 
A 1 186 ALA 186 178 178 ALA ALA A . n 
A 1 187 GLU 187 179 179 GLU GLU A . n 
A 1 188 GLN 188 180 180 GLN GLN A . n 
A 1 189 ILE 189 181 181 ILE ILE A . n 
A 1 190 LEU 190 182 182 LEU LEU A . n 
A 1 191 ALA 191 183 183 ALA ALA A . n 
A 1 192 THR 192 184 184 THR THR A . n 
A 1 193 LEU 193 185 185 LEU LEU A . n 
A 1 194 PHE 194 186 186 PHE PHE A . n 
A 1 195 GLN 195 187 187 GLN GLN A . n 
A 1 196 THR 196 188 188 THR THR A . n 
A 1 197 TRP 197 189 189 TRP TRP A . n 
A 1 198 MET 198 190 190 MET MET A . n 
A 1 199 VAL 199 191 191 VAL VAL A . n 
A 1 200 PRO 200 192 192 PRO PRO A . n 
A 1 201 ALA 201 193 193 ALA ALA A . n 
A 1 202 VAL 202 194 194 VAL VAL A . n 
A 1 203 ARG 203 195 195 ARG ARG A . n 
A 1 204 VAL 204 196 196 VAL VAL A . n 
A 1 205 ASP 205 197 197 ASP ASP A . n 
A 1 206 PHE 206 198 198 PHE PHE A . n 
A 1 207 TYR 207 199 199 TYR TYR A . n 
A 1 208 ASN 208 200 200 ASN ASN A . n 
A 1 209 ALA 209 201 201 ALA ALA A . n 
A 1 210 ASP 210 202 202 ASP ASP A . n 
A 1 211 GLU 211 203 203 GLU GLU A . n 
A 1 212 LEU 212 204 204 LEU LEU A . n 
A 1 213 LYS 213 205 205 LYS LYS A . n 
A 1 214 SER 214 206 206 SER SER A . n 
A 1 215 GLU 215 207 207 GLU GLU A . n 
A 1 216 VAL 216 208 208 VAL VAL A . n 
A 1 217 SER 217 209 209 SER SER A . n 
A 1 218 TRP 218 210 210 TRP TRP A . n 
A 1 219 ILE 219 211 211 ILE ILE A . n 
A 1 220 PRO 220 212 212 PRO PRO A . n 
A 1 221 ASN 221 213 213 ASN ASN A . n 
A 1 222 LYS 222 214 214 LYS LYS A . n 
A 1 223 HIS 223 215 215 HIS HIS A . n 
A 1 224 TYR 224 216 216 TYR TYR A . n 
A 1 225 SER 225 217 217 SER SER A . n 
A 1 226 GLY 226 218 218 GLY GLY A . n 
A 1 227 ILE 227 219 219 ILE ILE A . n 
A 1 228 TYR 228 220 220 TYR TYR A . n 
A 1 229 GLY 229 221 221 GLY GLY A . n 
A 1 230 LEU 230 222 222 LEU LEU A . n 
A 1 231 MET 231 223 223 MET MET A . n 
A 1 232 LYS 232 224 224 LYS LYS A . n 
A 1 233 LEU 233 225 225 LEU LEU A . n 
A 1 234 VAL 234 226 226 VAL VAL A . n 
A 1 235 LEU 235 227 227 LEU LEU A . n 
A 1 236 THR 236 228 228 THR THR A . n 
A 1 237 LYS 237 229 229 LYS LYS A . n 
A 1 238 THR 238 230 230 THR THR A . n 
A 1 239 LEU 239 231 231 LEU LEU A . n 
A 1 240 PRO 240 232 232 PRO PRO A . n 
A 1 241 ALA 241 233 233 ALA ALA A . n 
A 1 242 ASN 242 234 234 ASN ASN A . n 
A 1 243 LEU 243 235 235 LEU LEU A . n 
A 1 244 GLU 244 236 236 GLU GLU A . n 
A 1 245 ARG 245 237 237 ARG ARG A . n 
A 1 246 VAL 246 238 238 VAL VAL A . n 
A 1 247 ILE 247 239 239 ILE ILE A . n 
A 1 248 VAL 248 240 240 VAL VAL A . n 
A 1 249 LEU 249 241 241 LEU LEU A . n 
A 1 250 ASP 250 242 242 ASP ASP A . n 
A 1 251 THR 251 243 243 THR THR A . n 
A 1 252 ASP 252 244 244 ASP ASP A . n 
A 1 253 ILE 253 245 245 ILE ILE A . n 
A 1 254 THR 254 246 246 THR THR A . n 
A 1 255 PHE 255 247 247 PHE PHE A . n 
A 1 256 ALA 256 248 248 ALA ALA A . n 
A 1 257 THR 257 249 249 THR THR A . n 
A 1 258 ASP 258 250 250 ASP ASP A . n 
A 1 259 ILE 259 251 251 ILE ILE A . n 
A 1 260 ALA 260 252 252 ALA ALA A . n 
A 1 261 GLU 261 253 253 GLU GLU A . n 
A 1 262 LEU 262 254 254 LEU LEU A . n 
A 1 263 TRP 263 255 255 TRP TRP A . n 
A 1 264 ALA 264 256 256 ALA ALA A . n 
A 1 265 VAL 265 257 257 VAL VAL A . n 
A 1 266 PHE 266 258 258 PHE PHE A . n 
A 1 267 HIS 267 259 259 HIS HIS A . n 
A 1 268 LYS 268 260 260 LYS LYS A . n 
A 1 269 PHE 269 261 261 PHE PHE A . n 
A 1 270 LYS 270 262 262 LYS LYS A . n 
A 1 271 GLY 271 263 263 GLY GLY A . n 
A 1 272 GLN 272 264 264 GLN GLN A . n 
A 1 273 GLN 273 265 265 GLN GLN A . n 
A 1 274 VAL 274 266 266 VAL VAL A . n 
A 1 275 LEU 275 267 267 LEU LEU A . n 
A 1 276 GLY 276 268 268 GLY GLY A . n 
A 1 277 LEU 277 269 269 LEU LEU A . n 
A 1 278 VAL 278 270 270 VAL VAL A . n 
A 1 279 GLU 279 271 271 GLU GLU A . n 
A 1 280 ASN 280 272 272 ASN ASN A . n 
A 1 281 GLN 281 273 273 GLN GLN A . n 
A 1 282 SER 282 274 274 SER SER A . n 
A 1 283 ASP 283 275 275 ASP ASP A . n 
A 1 284 TRP 284 276 276 TRP TRP A . n 
A 1 285 TYR 285 277 277 TYR TYR A . n 
A 1 286 LEU 286 278 278 LEU LEU A . n 
A 1 287 GLY 287 279 279 GLY GLY A . n 
A 1 288 ASN 288 280 ?   ?   ?   A . n 
A 1 289 LEU 289 281 ?   ?   ?   A . n 
A 1 290 TRP 290 282 ?   ?   ?   A . n 
A 1 291 LYS 291 283 ?   ?   ?   A . n 
A 1 292 ASN 292 284 ?   ?   ?   A . n 
A 1 293 HIS 293 285 ?   ?   ?   A . n 
A 1 294 ARG 294 286 ?   ?   ?   A . n 
A 1 295 PRO 295 287 287 PRO PRO A . n 
A 1 296 TRP 296 288 288 TRP TRP A . n 
A 1 297 PRO 297 289 289 PRO PRO A . n 
A 1 298 ALA 298 290 290 ALA ALA A . n 
A 1 299 LEU 299 291 291 LEU LEU A . n 
A 1 300 GLY 300 292 292 GLY GLY A . n 
A 1 301 ARG 301 293 293 ARG ARG A . n 
A 1 302 GLY 302 294 294 GLY GLY A . n 
A 1 303 TYR 303 295 295 TYR TYR A . n 
A 1 304 ASN 304 296 296 ASN ASN A . n 
A 1 305 THR 305 297 297 THR THR A . n 
A 1 306 GLY 306 298 298 GLY GLY A . n 
A 1 307 VAL 307 299 299 VAL VAL A . n 
A 1 308 ILE 308 300 300 ILE ILE A . n 
A 1 309 LEU 309 301 301 LEU LEU A . n 
A 1 310 LEU 310 302 302 LEU LEU A . n 
A 1 311 LEU 311 303 303 LEU LEU A . n 
A 1 312 LEU 312 304 304 LEU LEU A . n 
A 1 313 ASP 313 305 305 ASP ASP A . n 
A 1 314 LYS 314 306 306 LYS LYS A . n 
A 1 315 LEU 315 307 307 LEU LEU A . n 
A 1 316 ARG 316 308 308 ARG ARG A . n 
A 1 317 LYS 317 309 309 LYS LYS A . n 
A 1 318 MET 318 310 310 MET MET A . n 
A 1 319 LYS 319 311 311 LYS LYS A . n 
A 1 320 TRP 320 312 312 TRP TRP A . n 
A 1 321 GLU 321 313 313 GLU GLU A . n 
A 1 322 GLN 322 314 314 GLN GLN A . n 
A 1 323 MET 323 315 315 MET MET A . n 
A 1 324 TRP 324 316 316 TRP TRP A . n 
A 1 325 ARG 325 317 317 ARG ARG A . n 
A 1 326 LEU 326 318 318 LEU LEU A . n 
A 1 327 THR 327 319 319 THR THR A . n 
A 1 328 ALA 328 320 320 ALA ALA A . n 
A 1 329 GLU 329 321 321 GLU GLU A . n 
A 1 330 ARG 330 322 322 ARG ARG A . n 
A 1 331 GLU 331 323 323 GLU GLU A . n 
A 1 332 LEU 332 324 324 LEU LEU A . n 
A 1 333 MET 333 325 325 MET MET A . n 
A 1 334 GLY 334 326 326 GLY GLY A . n 
A 1 335 MET 335 327 327 MET MET A . n 
A 1 336 LEU 336 328 328 LEU LEU A . n 
A 1 337 SER 337 329 329 SER SER A . n 
A 1 338 THR 338 330 330 THR THR A . n 
A 1 339 SER 339 331 331 SER SER A . n 
A 1 340 LEU 340 332 332 LEU LEU A . n 
A 1 341 ALA 341 333 333 ALA ALA A . n 
A 1 342 ASP 342 334 334 ASP ASP A . n 
A 1 343 GLN 343 335 335 GLN GLN A . n 
A 1 344 ASP 344 336 336 ASP ASP A . n 
A 1 345 ILE 345 337 337 ILE ILE A . n 
A 1 346 PHE 346 338 338 PHE PHE A . n 
A 1 347 ASN 347 339 339 ASN ASN A . n 
A 1 348 ALA 348 340 340 ALA ALA A . n 
A 1 349 VAL 349 341 341 VAL VAL A . n 
A 1 350 ILE 350 342 342 ILE ILE A . n 
A 1 351 LYS 351 343 343 LYS LYS A . n 
A 1 352 GLN 352 344 344 GLN GLN A . n 
A 1 353 ASN 353 345 345 ASN ASN A . n 
A 1 354 PRO 354 346 346 PRO PRO A . n 
A 1 355 PHE 355 347 347 PHE PHE A . n 
A 1 356 LEU 356 348 348 LEU LEU A . n 
A 1 357 VAL 357 349 349 VAL VAL A . n 
A 1 358 TYR 358 350 350 TYR TYR A . n 
A 1 359 GLN 359 351 351 GLN GLN A . n 
A 1 360 LEU 360 352 352 LEU LEU A . n 
A 1 361 PRO 361 353 353 PRO PRO A . n 
A 1 362 CYS 362 354 354 CYS CYS A . n 
A 1 363 PHE 363 355 355 PHE PHE A . n 
A 1 364 TRP 364 356 356 TRP TRP A . n 
A 1 365 ASN 365 357 357 ASN ASN A . n 
A 1 366 VAL 366 358 358 VAL VAL A . n 
A 1 367 GLN 367 359 359 GLN GLN A . n 
A 1 368 LEU 368 360 360 LEU LEU A . n 
A 1 369 SER 369 361 361 SER SER A . n 
A 1 370 ASP 370 362 362 ASP ASP A . n 
A 1 371 HIS 371 363 363 HIS HIS A . n 
A 1 372 THR 372 364 364 THR THR A . n 
A 1 373 ARG 373 365 365 ARG ARG A . n 
A 1 374 SER 374 366 366 SER SER A . n 
A 1 375 GLU 375 367 367 GLU GLU A . n 
A 1 376 GLN 376 368 368 GLN GLN A . n 
A 1 377 CYS 377 369 369 CYS CYS A . n 
A 1 378 TYR 378 370 370 TYR TYR A . n 
A 1 379 ARG 379 371 371 ARG ARG A . n 
A 1 380 ASP 380 372 372 ASP ASP A . n 
A 1 381 VAL 381 373 373 VAL VAL A . n 
A 1 382 SER 382 374 374 SER SER A . n 
A 1 383 ASP 383 375 375 ASP ASP A . n 
A 1 384 LEU 384 376 376 LEU LEU A . n 
A 1 385 LYS 385 377 377 LYS LYS A . n 
A 1 386 VAL 386 378 378 VAL VAL A . n 
A 1 387 ILE 387 379 379 ILE ILE A . n 
A 1 388 HIS 388 380 380 HIS HIS A . n 
A 1 389 TRP 389 381 381 TRP TRP A . n 
A 1 390 ASN 390 382 382 ASN ASN A . n 
A 1 391 SER 391 383 383 SER SER A . n 
A 1 392 PRO 392 384 384 PRO PRO A . n 
A 1 393 LYS 393 385 ?   ?   ?   A . n 
A 1 394 LYS 394 386 ?   ?   ?   A . n 
A 1 395 LEU 395 387 ?   ?   ?   A . n 
A 1 396 ARG 396 388 ?   ?   ?   A . n 
A 1 397 VAL 397 389 ?   ?   ?   A . n 
A 1 398 LYS 398 390 ?   ?   ?   A . n 
A 1 399 ASN 399 391 ?   ?   ?   A . n 
A 1 400 LYS 400 392 ?   ?   ?   A . n 
A 1 401 HIS 401 393 ?   ?   ?   A . n 
A 1 402 VAL 402 394 ?   ?   ?   A . n 
A 1 403 GLU 403 395 395 GLU GLU A . n 
A 1 404 PHE 404 396 396 PHE PHE A . n 
A 1 405 PHE 405 397 397 PHE PHE A . n 
A 1 406 ARG 406 398 398 ARG ARG A . n 
A 1 407 ASN 407 399 399 ASN ASN A . n 
A 1 408 LEU 408 400 400 LEU LEU A . n 
A 1 409 TYR 409 401 401 TYR TYR A . n 
A 1 410 LEU 410 402 402 LEU LEU A . n 
A 1 411 THR 411 403 403 THR THR A . n 
A 1 412 PHE 412 404 404 PHE PHE A . n 
A 1 413 LEU 413 405 405 LEU LEU A . n 
A 1 414 GLU 414 406 406 GLU GLU A . n 
A 1 415 TYR 415 407 407 TYR TYR A . n 
A 1 416 ASP 416 408 408 ASP ASP A . n 
A 1 417 GLY 417 409 409 GLY GLY A . n 
A 1 418 ASN 418 410 410 ASN ASN A . n 
A 1 419 LEU 419 411 411 LEU LEU A . n 
A 1 420 LEU 420 412 412 LEU LEU A . n 
A 1 421 ARG 421 413 413 ARG ARG A . n 
A 1 422 ARG 422 414 414 ARG ARG A . n 
A 1 423 GLU 423 415 415 GLU GLU A . n 
A 1 424 LEU 424 416 416 LEU LEU A . n 
A 1 425 PHE 425 417 417 PHE PHE A . n 
A 1 426 GLY 426 418 418 GLY GLY A . n 
A 1 427 CYS 427 419 419 CYS CYS A . n 
A 1 428 PRO 428 420 420 PRO PRO A . n 
A 1 429 SER 429 421 421 SER SER A . n 
A 1 430 GLU 430 422 422 GLU GLU A . n 
A 1 431 ALA 431 423 423 ALA ALA A . n 
A 1 432 ASP 432 424 424 ASP ASP A . n 
A 1 433 VAL 433 425 425 VAL VAL A . n 
A 1 434 ASN 434 426 426 ASN ASN A . n 
A 1 435 SER 435 427 427 SER SER A . n 
A 1 436 GLU 436 428 428 GLU GLU A . n 
A 1 437 ASN 437 429 429 ASN ASN A . n 
A 1 438 LEU 438 430 430 LEU LEU A . n 
A 1 439 GLN 439 431 431 GLN GLN A . n 
A 1 440 LYS 440 432 432 LYS LYS A . n 
A 1 441 GLN 441 433 433 GLN GLN A . n 
A 1 442 LEU 442 434 434 LEU LEU A . n 
A 1 443 SER 443 435 435 SER SER A . n 
A 1 444 GLU 444 436 436 GLU GLU A . n 
A 1 445 LEU 445 437 437 LEU LEU A . n 
A 1 446 ASP 446 438 438 ASP ASP A . n 
A 1 447 GLU 447 439 439 GLU GLU A . n 
A 1 448 ASP 448 440 440 ASP ASP A . n 
A 1 449 ASP 449 441 441 ASP ASP A . n 
A 1 450 LEU 450 442 442 LEU LEU A . n 
A 1 451 CYS 451 443 443 CYS CYS A . n 
A 1 452 TYR 452 444 444 TYR TYR A . n 
A 1 453 GLU 453 445 445 GLU GLU A . n 
A 1 454 PHE 454 446 446 PHE PHE A . n 
A 1 455 ARG 455 447 447 ARG ARG A . n 
A 1 456 ARG 456 448 448 ARG ARG A . n 
A 1 457 GLU 457 449 449 GLU GLU A . n 
A 1 458 ARG 458 450 450 ARG ARG A . n 
A 1 459 PHE 459 451 451 PHE PHE A . n 
A 1 460 THR 460 452 452 THR THR A . n 
A 1 461 VAL 461 453 453 VAL VAL A . n 
A 1 462 HIS 462 454 454 HIS HIS A . n 
A 1 463 ARG 463 455 455 ARG ARG A . n 
A 1 464 THR 464 456 456 THR THR A . n 
A 1 465 HIS 465 457 457 HIS HIS A . n 
A 1 466 LEU 466 458 458 LEU LEU A . n 
A 1 467 TYR 467 459 459 TYR TYR A . n 
A 1 468 PHE 468 460 460 PHE PHE A . n 
A 1 469 LEU 469 461 461 LEU LEU A . n 
A 1 470 HIS 470 462 462 HIS HIS A . n 
A 1 471 TYR 471 463 463 TYR TYR A . n 
A 1 472 GLU 472 464 464 GLU GLU A . n 
A 1 473 TYR 473 465 465 TYR TYR A . n 
A 1 474 GLU 474 466 466 GLU GLU A . n 
A 1 475 PRO 475 467 467 PRO PRO A . n 
A 1 476 ALA 476 468 468 ALA ALA A . n 
A 1 477 ALA 477 469 469 ALA ALA A . n 
A 1 478 ASP 478 470 470 ASP ASP A . n 
A 1 479 SER 479 471 471 SER SER A . n 
A 1 480 THR 480 472 472 THR THR A . n 
A 1 481 ASP 481 473 473 ASP ASP A . n 
A 1 482 VAL 482 474 474 VAL VAL A . n 
A 1 483 THR 483 475 475 THR THR A . n 
A 1 484 LEU 484 476 476 LEU LEU A . n 
A 1 485 VAL 485 477 477 VAL VAL A . n 
A 1 486 ALA 486 478 478 ALA ALA A . n 
A 1 487 GLN 487 479 479 GLN GLN A . n 
A 1 488 LEU 488 480 480 LEU LEU A . n 
A 1 489 SER 489 481 481 SER SER A . n 
A 1 490 MET 490 482 482 MET MET A . n 
A 1 491 ASP 491 483 483 ASP ASP A . n 
A 1 492 ARG 492 484 484 ARG ARG A . n 
A 1 493 LEU 493 485 485 LEU LEU A . n 
A 1 494 GLN 494 486 486 GLN GLN A . n 
A 1 495 MET 495 487 487 MET MET A . n 
A 1 496 LEU 496 488 488 LEU LEU A . n 
A 1 497 GLU 497 489 489 GLU GLU A . n 
A 1 498 ALA 498 490 490 ALA ALA A . n 
A 1 499 ILE 499 491 491 ILE ILE A . n 
A 1 500 CYS 500 492 492 CYS CYS A . n 
A 1 501 LYS 501 493 493 LYS LYS A . n 
A 1 502 HIS 502 494 494 HIS HIS A . n 
A 1 503 TRP 503 495 495 TRP TRP A . n 
A 1 504 GLU 504 496 496 GLU GLU A . n 
A 1 505 GLY 505 497 497 GLY GLY A . n 
A 1 506 PRO 506 498 498 PRO PRO A . n 
A 1 507 ILE 507 499 499 ILE ILE A . n 
A 1 508 SER 508 500 500 SER SER A . n 
A 1 509 LEU 509 501 501 LEU LEU A . n 
A 1 510 ALA 510 502 502 ALA ALA A . n 
A 1 511 LEU 511 503 503 LEU LEU A . n 
A 1 512 TYR 512 504 504 TYR TYR A . n 
A 1 513 LEU 513 505 505 LEU LEU A . n 
A 1 514 SER 514 506 506 SER SER A . n 
A 1 515 ASP 515 507 507 ASP ASP A . n 
A 1 516 ALA 516 508 508 ALA ALA A . n 
A 1 517 GLU 517 509 509 GLU GLU A . n 
A 1 518 ALA 518 510 510 ALA ALA A . n 
A 1 519 GLN 519 511 511 GLN GLN A . n 
A 1 520 GLN 520 512 512 GLN GLN A . n 
A 1 521 PHE 521 513 513 PHE PHE A . n 
A 1 522 LEU 522 514 514 LEU LEU A . n 
A 1 523 ARG 523 515 515 ARG ARG A . n 
A 1 524 TYR 524 516 516 TYR TYR A . n 
A 1 525 ALA 525 517 517 ALA ALA A . n 
A 1 526 GLN 526 518 518 GLN GLN A . n 
A 1 527 GLY 527 519 519 GLY GLY A . n 
A 1 528 SER 528 520 520 SER SER A . n 
A 1 529 GLU 529 521 521 GLU GLU A . n 
A 1 530 VAL 530 522 522 VAL VAL A . n 
A 1 531 LEU 531 523 523 LEU LEU A . n 
A 1 532 MET 532 524 524 MET MET A . n 
A 1 533 SER 533 525 525 SER SER A . n 
A 1 534 ARG 534 526 526 ARG ARG A . n 
A 1 535 HIS 535 527 527 HIS HIS A . n 
A 1 536 ASN 536 528 528 ASN ASN A . n 
A 1 537 VAL 537 529 529 VAL VAL A . n 
A 1 538 GLY 538 530 530 GLY GLY A . n 
A 1 539 TYR 539 531 531 TYR TYR A . n 
A 1 540 HIS 540 532 532 HIS HIS A . n 
A 1 541 ILE 541 533 533 ILE ILE A . n 
A 1 542 VAL 542 534 534 VAL VAL A . n 
A 1 543 TYR 543 535 535 TYR TYR A . n 
A 1 544 LYS 544 536 536 LYS LYS A . n 
A 1 545 GLU 545 537 537 GLU GLU A . n 
A 1 546 GLY 546 538 538 GLY GLY A . n 
A 1 547 GLN 547 539 539 GLN GLN A . n 
A 1 548 PHE 548 540 540 PHE PHE A . n 
A 1 549 TYR 549 541 541 TYR TYR A . n 
A 1 550 PRO 550 542 542 PRO PRO A . n 
A 1 551 VAL 551 543 543 VAL VAL A . n 
A 1 552 ASN 552 544 544 ASN ASN A . n 
A 1 553 LEU 553 545 545 LEU LEU A . n 
A 1 554 LEU 554 546 546 LEU LEU A . n 
A 1 555 ARG 555 547 547 ARG ARG A . n 
A 1 556 ASN 556 548 548 ASN ASN A . n 
A 1 557 VAL 557 549 549 VAL VAL A . n 
A 1 558 ALA 558 550 550 ALA ALA A . n 
A 1 559 MET 559 551 551 MET MET A . n 
A 1 560 LYS 560 552 552 LYS LYS A . n 
A 1 561 HIS 561 553 553 HIS HIS A . n 
A 1 562 ILE 562 554 554 ILE ILE A . n 
A 1 563 SER 563 555 555 SER SER A . n 
A 1 564 THR 564 556 556 THR THR A . n 
A 1 565 PRO 565 557 557 PRO PRO A . n 
A 1 566 TYR 566 558 558 TYR TYR A . n 
A 1 567 MET 567 559 559 MET MET A . n 
A 1 568 PHE 568 560 560 PHE PHE A . n 
A 1 569 LEU 569 561 561 LEU LEU A . n 
A 1 570 SER 570 562 562 SER SER A . n 
A 1 571 ASP 571 563 563 ASP ASP A . n 
A 1 572 ILE 572 564 564 ILE ILE A . n 
A 1 573 ASP 573 565 565 ASP ASP A . n 
A 1 574 PHE 574 566 566 PHE PHE A . n 
A 1 575 LEU 575 567 567 LEU LEU A . n 
A 1 576 PRO 576 568 568 PRO PRO A . n 
A 1 577 MET 577 569 569 MET MET A . n 
A 1 578 TYR 578 570 570 TYR TYR A . n 
A 1 579 GLY 579 571 571 GLY GLY A . n 
A 1 580 LEU 580 572 572 LEU LEU A . n 
A 1 581 TYR 581 573 573 TYR TYR A . n 
A 1 582 GLU 582 574 574 GLU GLU A . n 
A 1 583 TYR 583 575 575 TYR TYR A . n 
A 1 584 LEU 584 576 576 LEU LEU A . n 
A 1 585 ARG 585 577 577 ARG ARG A . n 
A 1 586 LYS 586 578 578 LYS LYS A . n 
A 1 587 SER 587 579 579 SER SER A . n 
A 1 588 VAL 588 580 580 VAL VAL A . n 
A 1 589 ILE 589 581 581 ILE ILE A . n 
A 1 590 GLN 590 582 582 GLN GLN A . n 
A 1 591 LEU 591 583 583 LEU LEU A . n 
A 1 592 ASP 592 584 584 ASP ASP A . n 
A 1 593 LEU 593 585 585 LEU LEU A . n 
A 1 594 ALA 594 586 586 ALA ALA A . n 
A 1 595 ASN 595 587 587 ASN ASN A . n 
A 1 596 THR 596 588 588 THR THR A . n 
A 1 597 LYS 597 589 589 LYS LYS A . n 
A 1 598 LYS 598 590 590 LYS LYS A . n 
A 1 599 ALA 599 591 591 ALA ALA A . n 
A 1 600 MET 600 592 592 MET MET A . n 
A 1 601 ILE 601 593 593 ILE ILE A . n 
A 1 602 VAL 602 594 594 VAL VAL A . n 
A 1 603 PRO 603 595 595 PRO PRO A . n 
A 1 604 ALA 604 596 596 ALA ALA A . n 
A 1 605 PHE 605 597 597 PHE PHE A . n 
A 1 606 GLU 606 598 598 GLU GLU A . n 
A 1 607 THR 607 599 599 THR THR A . n 
A 1 608 LEU 608 600 600 LEU LEU A . n 
A 1 609 ARG 609 601 601 ARG ARG A . n 
A 1 610 TYR 610 602 602 TYR TYR A . n 
A 1 611 ARG 611 603 603 ARG ARG A . n 
A 1 612 LEU 612 604 604 LEU LEU A . n 
A 1 613 SER 613 605 605 SER SER A . n 
A 1 614 PHE 614 606 606 PHE PHE A . n 
A 1 615 PRO 615 607 607 PRO PRO A . n 
A 1 616 LYS 616 608 608 LYS LYS A . n 
A 1 617 SER 617 609 609 SER SER A . n 
A 1 618 LYS 618 610 610 LYS LYS A . n 
A 1 619 ALA 619 611 611 ALA ALA A . n 
A 1 620 GLU 620 612 612 GLU GLU A . n 
A 1 621 LEU 621 613 613 LEU LEU A . n 
A 1 622 LEU 622 614 614 LEU LEU A . n 
A 1 623 SER 623 615 615 SER SER A . n 
A 1 624 MET 624 616 616 MET MET A . n 
A 1 625 LEU 625 617 617 LEU LEU A . n 
A 1 626 ASP 626 618 618 ASP ASP A . n 
A 1 627 MET 627 619 619 MET MET A . n 
A 1 628 GLY 628 620 620 GLY GLY A . n 
A 1 629 THR 629 621 621 THR THR A . n 
A 1 630 LEU 630 622 622 LEU LEU A . n 
A 1 631 PHE 631 623 623 PHE PHE A . n 
A 1 632 THR 632 624 624 THR THR A . n 
A 1 633 PHE 633 625 625 PHE PHE A . n 
A 1 634 ARG 634 626 626 ARG ARG A . n 
A 1 635 TYR 635 627 627 TYR TYR A . n 
A 1 636 HIS 636 628 628 HIS HIS A . n 
A 1 637 VAL 637 629 629 VAL VAL A . n 
A 1 638 TRP 638 630 630 TRP TRP A . n 
A 1 639 THR 639 631 631 THR THR A . n 
A 1 640 LYS 640 632 632 LYS LYS A . n 
A 1 641 GLY 641 633 633 GLY GLY A . n 
A 1 642 HIS 642 634 634 HIS HIS A . n 
A 1 643 ALA 643 635 635 ALA ALA A . n 
A 1 644 PRO 644 636 636 PRO PRO A . n 
A 1 645 THR 645 637 637 THR THR A . n 
A 1 646 ASN 646 638 638 ASN ASN A . n 
A 1 647 PHE 647 639 639 PHE PHE A . n 
A 1 648 ALA 648 640 640 ALA ALA A . n 
A 1 649 LYS 649 641 641 LYS LYS A . n 
A 1 650 TRP 650 642 642 TRP TRP A . n 
A 1 651 ARG 651 643 643 ARG ARG A . n 
A 1 652 THR 652 644 644 THR THR A . n 
A 1 653 ALA 653 645 645 ALA ALA A . n 
A 1 654 THR 654 646 646 THR THR A . n 
A 1 655 THR 655 647 647 THR THR A . n 
A 1 656 PRO 656 648 648 PRO PRO A . n 
A 1 657 TYR 657 649 649 TYR TYR A . n 
A 1 658 ARG 658 650 650 ARG ARG A . n 
A 1 659 VAL 659 651 651 VAL VAL A . n 
A 1 660 GLU 660 652 652 GLU GLU A . n 
A 1 661 TRP 661 653 653 TRP TRP A . n 
A 1 662 GLU 662 654 654 GLU GLU A . n 
A 1 663 ALA 663 655 655 ALA ALA A . n 
A 1 664 ASP 664 656 656 ASP ASP A . n 
A 1 665 PHE 665 657 657 PHE PHE A . n 
A 1 666 GLU 666 658 658 GLU GLU A . n 
A 1 667 PRO 667 659 659 PRO PRO A . n 
A 1 668 TYR 668 660 660 TYR TYR A . n 
A 1 669 VAL 669 661 661 VAL VAL A . n 
A 1 670 VAL 670 662 662 VAL VAL A . n 
A 1 671 VAL 671 663 663 VAL VAL A . n 
A 1 672 ARG 672 664 664 ARG ARG A . n 
A 1 673 ARG 673 665 665 ARG ARG A . n 
A 1 674 ASP 674 666 666 ASP ASP A . n 
A 1 675 CYS 675 667 667 CYS CYS A . n 
A 1 676 PRO 676 668 668 PRO PRO A . n 
A 1 677 GLU 677 669 669 GLU GLU A . n 
A 1 678 TYR 678 670 670 TYR TYR A . n 
A 1 679 ASP 679 671 671 ASP ASP A . n 
A 1 680 ARG 680 672 672 ARG ARG A . n 
A 1 681 ARG 681 673 673 ARG ARG A . n 
A 1 682 PHE 682 674 674 PHE PHE A . n 
A 1 683 VAL 683 675 675 VAL VAL A . n 
A 1 684 GLY 684 676 676 GLY GLY A . n 
A 1 685 PHE 685 677 677 PHE PHE A . n 
A 1 686 GLY 686 678 678 GLY GLY A . n 
A 1 687 TRP 687 679 679 TRP TRP A . n 
A 1 688 ASN 688 680 680 ASN ASN A . n 
A 1 689 LYS 689 681 681 LYS LYS A . n 
A 1 690 VAL 690 682 682 VAL VAL A . n 
A 1 691 ALA 691 683 683 ALA ALA A . n 
A 1 692 HIS 692 684 684 HIS HIS A . n 
A 1 693 ILE 693 685 685 ILE ILE A . n 
A 1 694 MET 694 686 686 MET MET A . n 
A 1 695 GLU 695 687 687 GLU GLU A . n 
A 1 696 LEU 696 688 688 LEU LEU A . n 
A 1 697 ASP 697 689 689 ASP ASP A . n 
A 1 698 VAL 698 690 690 VAL VAL A . n 
A 1 699 GLN 699 691 691 GLN GLN A . n 
A 1 700 GLU 700 692 692 GLU GLU A . n 
A 1 701 TYR 701 693 693 TYR TYR A . n 
A 1 702 GLU 702 694 694 GLU GLU A . n 
A 1 703 PHE 703 695 695 PHE PHE A . n 
A 1 704 ILE 704 696 696 ILE ILE A . n 
A 1 705 VAL 705 697 697 VAL VAL A . n 
A 1 706 LEU 706 698 698 LEU LEU A . n 
A 1 707 PRO 707 699 699 PRO PRO A . n 
A 1 708 ASN 708 700 700 ASN ASN A . n 
A 1 709 ALA 709 701 701 ALA ALA A . n 
A 1 710 TYR 710 702 702 TYR TYR A . n 
A 1 711 MET 711 703 703 MET MET A . n 
A 1 712 ILE 712 704 704 ILE ILE A . n 
A 1 713 HIS 713 705 705 HIS HIS A . n 
A 1 714 MET 714 706 706 MET MET A . n 
A 1 715 PRO 715 707 707 PRO PRO A . n 
A 1 716 HIS 716 708 708 HIS HIS A . n 
A 1 717 ALA 717 709 709 ALA ALA A . n 
A 1 718 PRO 718 710 710 PRO PRO A . n 
A 1 719 SER 719 711 711 SER SER A . n 
A 1 720 PHE 720 712 712 PHE PHE A . n 
A 1 721 ASP 721 713 713 ASP ASP A . n 
A 1 722 ILE 722 714 714 ILE ILE A . n 
A 1 723 THR 723 715 715 THR THR A . n 
A 1 724 LYS 724 716 716 LYS LYS A . n 
A 1 725 PHE 725 717 717 PHE PHE A . n 
A 1 726 ARG 726 718 718 ARG ARG A . n 
A 1 727 SER 727 719 719 SER SER A . n 
A 1 728 ASN 728 720 720 ASN ASN A . n 
A 1 729 LYS 729 721 721 LYS LYS A . n 
A 1 730 GLN 730 722 722 GLN GLN A . n 
A 1 731 TYR 731 723 723 TYR TYR A . n 
A 1 732 ARG 732 724 724 ARG ARG A . n 
A 1 733 ILE 733 725 725 ILE ILE A . n 
A 1 734 CYS 734 726 726 CYS CYS A . n 
A 1 735 LEU 735 727 727 LEU LEU A . n 
A 1 736 LYS 736 728 728 LYS LYS A . n 
A 1 737 THR 737 729 729 THR THR A . n 
A 1 738 LEU 738 730 730 LEU LEU A . n 
A 1 739 LYS 739 731 731 LYS LYS A . n 
A 1 740 GLU 740 732 732 GLU GLU A . n 
A 1 741 GLU 741 733 733 GLU GLU A . n 
A 1 742 PHE 742 734 734 PHE PHE A . n 
A 1 743 GLN 743 735 735 GLN GLN A . n 
A 1 744 GLN 744 736 736 GLN GLN A . n 
A 1 745 ASP 745 737 737 ASP ASP A . n 
A 1 746 MET 746 738 738 MET MET A . n 
A 1 747 SER 747 739 739 SER SER A . n 
A 1 748 ARG 748 740 740 ARG ARG A . n 
A 1 749 ARG 749 741 741 ARG ARG A . n 
A 1 750 TYR 750 742 742 TYR TYR A . n 
A 1 751 GLY 751 743 743 GLY GLY A . n 
A 1 752 PHE 752 744 744 PHE PHE A . n 
A 1 753 ALA 753 745 745 ALA ALA A . n 
A 1 754 ALA 754 746 746 ALA ALA A . n 
A 1 755 LEU 755 747 747 LEU LEU A . n 
A 1 756 LYS 756 748 748 LYS LYS A . n 
A 1 757 TYR 757 749 749 TYR TYR A . n 
A 1 758 LEU 758 750 750 LEU LEU A . n 
A 1 759 THR 759 751 751 THR THR A . n 
A 1 760 ALA 760 752 752 ALA ALA A . n 
A 1 761 GLU 761 753 ?   ?   ?   A . n 
A 1 762 ASN 762 754 ?   ?   ?   A . n 
A 1 763 ASN 763 755 ?   ?   ?   A . n 
A 1 764 SER 764 756 ?   ?   ?   A . n 
A 1 765 HIS 765 757 ?   ?   ?   A . n 
A 1 766 HIS 766 758 ?   ?   ?   A . n 
A 1 767 HIS 767 759 ?   ?   ?   A . n 
A 1 768 HIS 768 760 ?   ?   ?   A . n 
A 1 769 HIS 769 761 ?   ?   ?   A . n 
A 1 770 HIS 770 762 ?   ?   ?   A . n 
B 1 1   MET 1   -7  ?   ?   ?   B . n 
B 1 2   SER 2   -6  ?   ?   ?   B . n 
B 1 3   ALA 3   -5  ?   ?   ?   B . n 
B 1 4   LEU 4   -4  ?   ?   ?   B . n 
B 1 5   LEU 5   -3  ?   ?   ?   B . n 
B 1 6   ILE 6   -2  ?   ?   ?   B . n 
B 1 7   LEU 7   -1  ?   ?   ?   B . n 
B 1 8   ALA 8   0   ?   ?   ?   B . n 
B 1 9   LEU 9   1   ?   ?   ?   B . n 
B 1 10  VAL 10  2   ?   ?   ?   B . n 
B 1 11  GLY 11  3   ?   ?   ?   B . n 
B 1 12  ALA 12  4   ?   ?   ?   B . n 
B 1 13  ALA 13  5   ?   ?   ?   B . n 
B 1 14  VAL 14  6   ?   ?   ?   B . n 
B 1 15  ALA 15  7   ?   ?   ?   B . n 
B 1 16  ASP 16  8   ?   ?   ?   B . n 
B 1 17  TYR 17  9   ?   ?   ?   B . n 
B 1 18  LYS 18  10  ?   ?   ?   B . n 
B 1 19  ASP 19  11  ?   ?   ?   B . n 
B 1 20  HIS 20  12  ?   ?   ?   B . n 
B 1 21  ASP 21  13  ?   ?   ?   B . n 
B 1 22  GLY 22  14  ?   ?   ?   B . n 
B 1 23  ASP 23  15  ?   ?   ?   B . n 
B 1 24  TYR 24  16  ?   ?   ?   B . n 
B 1 25  LYS 25  17  ?   ?   ?   B . n 
B 1 26  ASP 26  18  ?   ?   ?   B . n 
B 1 27  HIS 27  19  ?   ?   ?   B . n 
B 1 28  ASP 28  20  ?   ?   ?   B . n 
B 1 29  ILE 29  21  ?   ?   ?   B . n 
B 1 30  ASP 30  22  ?   ?   ?   B . n 
B 1 31  TYR 31  23  ?   ?   ?   B . n 
B 1 32  LYS 32  24  ?   ?   ?   B . n 
B 1 33  ASP 33  25  ?   ?   ?   B . n 
B 1 34  ASP 34  26  ?   ?   ?   B . n 
B 1 35  ASP 35  27  ?   ?   ?   B . n 
B 1 36  ASP 36  28  ?   ?   ?   B . n 
B 1 37  LYS 37  29  ?   ?   ?   B . n 
B 1 38  LEU 38  30  ?   ?   ?   B . n 
B 1 39  ALA 39  31  ?   ?   ?   B . n 
B 1 40  ALA 40  32  ?   ?   ?   B . n 
B 1 41  ALA 41  33  ?   ?   ?   B . n 
B 1 42  PHE 42  34  ?   ?   ?   B . n 
B 1 43  GLU 43  35  ?   ?   ?   B . n 
B 1 44  ASP 44  36  ?   ?   ?   B . n 
B 1 45  GLY 45  37  ?   ?   ?   B . n 
B 1 46  LYS 46  38  ?   ?   ?   B . n 
B 1 47  PRO 47  39  ?   ?   ?   B . n 
B 1 48  VAL 48  40  ?   ?   ?   B . n 
B 1 49  SER 49  41  ?   ?   ?   B . n 
B 1 50  LEU 50  42  ?   ?   ?   B . n 
B 1 51  SER 51  43  ?   ?   ?   B . n 
B 1 52  PRO 52  44  ?   ?   ?   B . n 
B 1 53  LEU 53  45  ?   ?   ?   B . n 
B 1 54  GLU 54  46  ?   ?   ?   B . n 
B 1 55  SER 55  47  ?   ?   ?   B . n 
B 1 56  GLN 56  48  ?   ?   ?   B . n 
B 1 57  ALA 57  49  ?   ?   ?   B . n 
B 1 58  HIS 58  50  ?   ?   ?   B . n 
B 1 59  SER 59  51  ?   ?   ?   B . n 
B 1 60  PRO 60  52  ?   ?   ?   B . n 
B 1 61  ARG 61  53  ?   ?   ?   B . n 
B 1 62  TYR 62  54  ?   ?   ?   B . n 
B 1 63  THR 63  55  ?   ?   ?   B . n 
B 1 64  ALA 64  56  ?   ?   ?   B . n 
B 1 65  SER 65  57  ?   ?   ?   B . n 
B 1 66  SER 66  58  ?   ?   ?   B . n 
B 1 67  GLN 67  59  ?   ?   ?   B . n 
B 1 68  ARG 68  60  ?   ?   ?   B . n 
B 1 69  GLU 69  61  ?   ?   ?   B . n 
B 1 70  ARG 70  62  ?   ?   ?   B . n 
B 1 71  GLU 71  63  ?   ?   ?   B . n 
B 1 72  SER 72  64  ?   ?   ?   B . n 
B 1 73  LEU 73  65  ?   ?   ?   B . n 
B 1 74  GLU 74  66  ?   ?   ?   B . n 
B 1 75  VAL 75  67  ?   ?   ?   B . n 
B 1 76  ARG 76  68  ?   ?   ?   B . n 
B 1 77  MET 77  69  ?   ?   ?   B . n 
B 1 78  ARG 78  70  ?   ?   ?   B . n 
B 1 79  GLU 79  71  ?   ?   ?   B . n 
B 1 80  VAL 80  72  ?   ?   ?   B . n 
B 1 81  GLU 81  73  ?   ?   ?   B . n 
B 1 82  GLU 82  74  ?   ?   ?   B . n 
B 1 83  GLU 83  75  ?   ?   ?   B . n 
B 1 84  ASN 84  76  ?   ?   ?   B . n 
B 1 85  ARG 85  77  ?   ?   ?   B . n 
B 1 86  ALA 86  78  ?   ?   ?   B . n 
B 1 87  LEU 87  79  ?   ?   ?   B . n 
B 1 88  ARG 88  80  ?   ?   ?   B . n 
B 1 89  ARG 89  81  ?   ?   ?   B . n 
B 1 90  GLN 90  82  ?   ?   ?   B . n 
B 1 91  LEU 91  83  ?   ?   ?   B . n 
B 1 92  SER 92  84  ?   ?   ?   B . n 
B 1 93  LEU 93  85  ?   ?   ?   B . n 
B 1 94  ALA 94  86  ?   ?   ?   B . n 
B 1 95  GLN 95  87  ?   ?   ?   B . n 
B 1 96  GLY 96  88  ?   ?   ?   B . n 
B 1 97  ARG 97  89  ?   ?   ?   B . n 
B 1 98  ALA 98  90  ?   ?   ?   B . n 
B 1 99  PRO 99  91  ?   ?   ?   B . n 
B 1 100 SER 100 92  ?   ?   ?   B . n 
B 1 101 HIS 101 93  ?   ?   ?   B . n 
B 1 102 ARG 102 94  ?   ?   ?   B . n 
B 1 103 ARG 103 95  ?   ?   ?   B . n 
B 1 104 GLY 104 96  ?   ?   ?   B . n 
B 1 105 ASN 105 97  ?   ?   ?   B . n 
B 1 106 HIS 106 98  ?   ?   ?   B . n 
B 1 107 SER 107 99  ?   ?   ?   B . n 
B 1 108 LYS 108 100 ?   ?   ?   B . n 
B 1 109 THR 109 101 ?   ?   ?   B . n 
B 1 110 TYR 110 102 ?   ?   ?   B . n 
B 1 111 SER 111 103 ?   ?   ?   B . n 
B 1 112 MET 112 104 ?   ?   ?   B . n 
B 1 113 GLU 113 105 ?   ?   ?   B . n 
B 1 114 GLU 114 106 ?   ?   ?   B . n 
B 1 115 GLY 115 107 ?   ?   ?   B . n 
B 1 116 THR 116 108 ?   ?   ?   B . n 
B 1 117 GLY 117 109 ?   ?   ?   B . n 
B 1 118 ASP 118 110 ?   ?   ?   B . n 
B 1 119 SER 119 111 ?   ?   ?   B . n 
B 1 120 GLU 120 112 ?   ?   ?   B . n 
B 1 121 ASN 121 113 ?   ?   ?   B . n 
B 1 122 LEU 122 114 ?   ?   ?   B . n 
B 1 123 ARG 123 115 ?   ?   ?   B . n 
B 1 124 ALA 124 116 ?   ?   ?   B . n 
B 1 125 GLY 125 117 ?   ?   ?   B . n 
B 1 126 ILE 126 118 ?   ?   ?   B . n 
B 1 127 VAL 127 119 ?   ?   ?   B . n 
B 1 128 ALA 128 120 ?   ?   ?   B . n 
B 1 129 GLY 129 121 ?   ?   ?   B . n 
B 1 130 ASN 130 122 ?   ?   ?   B . n 
B 1 131 SER 131 123 ?   ?   ?   B . n 
B 1 132 SER 132 124 ?   ?   ?   B . n 
B 1 133 GLU 133 125 ?   ?   ?   B . n 
B 1 134 CYS 134 126 ?   ?   ?   B . n 
B 1 135 GLY 135 127 ?   ?   ?   B . n 
B 1 136 GLN 136 128 ?   ?   ?   B . n 
B 1 137 GLN 137 129 ?   ?   ?   B . n 
B 1 138 PRO 138 130 ?   ?   ?   B . n 
B 1 139 VAL 139 131 ?   ?   ?   B . n 
B 1 140 VAL 140 132 ?   ?   ?   B . n 
B 1 141 GLU 141 133 ?   ?   ?   B . n 
B 1 142 LYS 142 134 134 LYS LYS B . n 
B 1 143 CYS 143 135 135 CYS CYS B . n 
B 1 144 GLU 144 136 136 GLU GLU B . n 
B 1 145 THR 145 137 137 THR THR B . n 
B 1 146 ILE 146 138 138 ILE ILE B . n 
B 1 147 HIS 147 139 139 HIS HIS B . n 
B 1 148 VAL 148 140 140 VAL VAL B . n 
B 1 149 ALA 149 141 141 ALA ALA B . n 
B 1 150 ILE 150 142 142 ILE ILE B . n 
B 1 151 VAL 151 143 143 VAL VAL B . n 
B 1 152 CYS 152 144 144 CYS CYS B . n 
B 1 153 ALA 153 145 145 ALA ALA B . n 
B 1 154 GLY 154 146 146 GLY GLY B . n 
B 1 155 TYR 155 147 147 TYR TYR B . n 
B 1 156 ASN 156 148 148 ASN ASN B . n 
B 1 157 ALA 157 149 149 ALA ALA B . n 
B 1 158 SER 158 150 150 SER SER B . n 
B 1 159 ARG 159 151 151 ARG ARG B . n 
B 1 160 ASP 160 152 152 ASP ASP B . n 
B 1 161 VAL 161 153 153 VAL VAL B . n 
B 1 162 VAL 162 154 154 VAL VAL B . n 
B 1 163 THR 163 155 155 THR THR B . n 
B 1 164 LEU 164 156 156 LEU LEU B . n 
B 1 165 VAL 165 157 157 VAL VAL B . n 
B 1 166 LYS 166 158 158 LYS LYS B . n 
B 1 167 SER 167 159 159 SER SER B . n 
B 1 168 VAL 168 160 160 VAL VAL B . n 
B 1 169 LEU 169 161 161 LEU LEU B . n 
B 1 170 PHE 170 162 162 PHE PHE B . n 
B 1 171 HIS 171 163 163 HIS HIS B . n 
B 1 172 ARG 172 164 164 ARG ARG B . n 
B 1 173 ARG 173 165 165 ARG ARG B . n 
B 1 174 ASN 174 166 166 ASN ASN B . n 
B 1 175 PRO 175 167 167 PRO PRO B . n 
B 1 176 LEU 176 168 168 LEU LEU B . n 
B 1 177 HIS 177 169 169 HIS HIS B . n 
B 1 178 PHE 178 170 170 PHE PHE B . n 
B 1 179 HIS 179 171 171 HIS HIS B . n 
B 1 180 LEU 180 172 172 LEU LEU B . n 
B 1 181 ILE 181 173 173 ILE ILE B . n 
B 1 182 ALA 182 174 174 ALA ALA B . n 
B 1 183 ASP 183 175 175 ASP ASP B . n 
B 1 184 SER 184 176 176 SER SER B . n 
B 1 185 ILE 185 177 177 ILE ILE B . n 
B 1 186 ALA 186 178 178 ALA ALA B . n 
B 1 187 GLU 187 179 179 GLU GLU B . n 
B 1 188 GLN 188 180 180 GLN GLN B . n 
B 1 189 ILE 189 181 181 ILE ILE B . n 
B 1 190 LEU 190 182 182 LEU LEU B . n 
B 1 191 ALA 191 183 183 ALA ALA B . n 
B 1 192 THR 192 184 184 THR THR B . n 
B 1 193 LEU 193 185 185 LEU LEU B . n 
B 1 194 PHE 194 186 186 PHE PHE B . n 
B 1 195 GLN 195 187 187 GLN GLN B . n 
B 1 196 THR 196 188 188 THR THR B . n 
B 1 197 TRP 197 189 189 TRP TRP B . n 
B 1 198 MET 198 190 190 MET MET B . n 
B 1 199 VAL 199 191 191 VAL VAL B . n 
B 1 200 PRO 200 192 192 PRO PRO B . n 
B 1 201 ALA 201 193 193 ALA ALA B . n 
B 1 202 VAL 202 194 194 VAL VAL B . n 
B 1 203 ARG 203 195 195 ARG ARG B . n 
B 1 204 VAL 204 196 196 VAL VAL B . n 
B 1 205 ASP 205 197 197 ASP ASP B . n 
B 1 206 PHE 206 198 198 PHE PHE B . n 
B 1 207 TYR 207 199 199 TYR TYR B . n 
B 1 208 ASN 208 200 200 ASN ASN B . n 
B 1 209 ALA 209 201 201 ALA ALA B . n 
B 1 210 ASP 210 202 202 ASP ASP B . n 
B 1 211 GLU 211 203 203 GLU GLU B . n 
B 1 212 LEU 212 204 204 LEU LEU B . n 
B 1 213 LYS 213 205 205 LYS LYS B . n 
B 1 214 SER 214 206 206 SER SER B . n 
B 1 215 GLU 215 207 207 GLU GLU B . n 
B 1 216 VAL 216 208 208 VAL VAL B . n 
B 1 217 SER 217 209 209 SER SER B . n 
B 1 218 TRP 218 210 210 TRP TRP B . n 
B 1 219 ILE 219 211 211 ILE ILE B . n 
B 1 220 PRO 220 212 212 PRO PRO B . n 
B 1 221 ASN 221 213 213 ASN ASN B . n 
B 1 222 LYS 222 214 214 LYS LYS B . n 
B 1 223 HIS 223 215 215 HIS HIS B . n 
B 1 224 TYR 224 216 216 TYR TYR B . n 
B 1 225 SER 225 217 217 SER SER B . n 
B 1 226 GLY 226 218 218 GLY GLY B . n 
B 1 227 ILE 227 219 219 ILE ILE B . n 
B 1 228 TYR 228 220 220 TYR TYR B . n 
B 1 229 GLY 229 221 221 GLY GLY B . n 
B 1 230 LEU 230 222 222 LEU LEU B . n 
B 1 231 MET 231 223 223 MET MET B . n 
B 1 232 LYS 232 224 224 LYS LYS B . n 
B 1 233 LEU 233 225 225 LEU LEU B . n 
B 1 234 VAL 234 226 226 VAL VAL B . n 
B 1 235 LEU 235 227 227 LEU LEU B . n 
B 1 236 THR 236 228 228 THR THR B . n 
B 1 237 LYS 237 229 229 LYS LYS B . n 
B 1 238 THR 238 230 230 THR THR B . n 
B 1 239 LEU 239 231 231 LEU LEU B . n 
B 1 240 PRO 240 232 232 PRO PRO B . n 
B 1 241 ALA 241 233 233 ALA ALA B . n 
B 1 242 ASN 242 234 234 ASN ASN B . n 
B 1 243 LEU 243 235 235 LEU LEU B . n 
B 1 244 GLU 244 236 236 GLU GLU B . n 
B 1 245 ARG 245 237 237 ARG ARG B . n 
B 1 246 VAL 246 238 238 VAL VAL B . n 
B 1 247 ILE 247 239 239 ILE ILE B . n 
B 1 248 VAL 248 240 240 VAL VAL B . n 
B 1 249 LEU 249 241 241 LEU LEU B . n 
B 1 250 ASP 250 242 242 ASP ASP B . n 
B 1 251 THR 251 243 243 THR THR B . n 
B 1 252 ASP 252 244 244 ASP ASP B . n 
B 1 253 ILE 253 245 245 ILE ILE B . n 
B 1 254 THR 254 246 246 THR THR B . n 
B 1 255 PHE 255 247 247 PHE PHE B . n 
B 1 256 ALA 256 248 248 ALA ALA B . n 
B 1 257 THR 257 249 249 THR THR B . n 
B 1 258 ASP 258 250 250 ASP ASP B . n 
B 1 259 ILE 259 251 251 ILE ILE B . n 
B 1 260 ALA 260 252 252 ALA ALA B . n 
B 1 261 GLU 261 253 253 GLU GLU B . n 
B 1 262 LEU 262 254 254 LEU LEU B . n 
B 1 263 TRP 263 255 255 TRP TRP B . n 
B 1 264 ALA 264 256 256 ALA ALA B . n 
B 1 265 VAL 265 257 257 VAL VAL B . n 
B 1 266 PHE 266 258 258 PHE PHE B . n 
B 1 267 HIS 267 259 259 HIS HIS B . n 
B 1 268 LYS 268 260 260 LYS LYS B . n 
B 1 269 PHE 269 261 261 PHE PHE B . n 
B 1 270 LYS 270 262 262 LYS LYS B . n 
B 1 271 GLY 271 263 263 GLY GLY B . n 
B 1 272 GLN 272 264 264 GLN GLN B . n 
B 1 273 GLN 273 265 265 GLN GLN B . n 
B 1 274 VAL 274 266 266 VAL VAL B . n 
B 1 275 LEU 275 267 267 LEU LEU B . n 
B 1 276 GLY 276 268 268 GLY GLY B . n 
B 1 277 LEU 277 269 269 LEU LEU B . n 
B 1 278 VAL 278 270 270 VAL VAL B . n 
B 1 279 GLU 279 271 271 GLU GLU B . n 
B 1 280 ASN 280 272 272 ASN ASN B . n 
B 1 281 GLN 281 273 273 GLN GLN B . n 
B 1 282 SER 282 274 274 SER SER B . n 
B 1 283 ASP 283 275 275 ASP ASP B . n 
B 1 284 TRP 284 276 276 TRP TRP B . n 
B 1 285 TYR 285 277 277 TYR TYR B . n 
B 1 286 LEU 286 278 278 LEU LEU B . n 
B 1 287 GLY 287 279 279 GLY GLY B . n 
B 1 288 ASN 288 280 ?   ?   ?   B . n 
B 1 289 LEU 289 281 ?   ?   ?   B . n 
B 1 290 TRP 290 282 ?   ?   ?   B . n 
B 1 291 LYS 291 283 ?   ?   ?   B . n 
B 1 292 ASN 292 284 ?   ?   ?   B . n 
B 1 293 HIS 293 285 ?   ?   ?   B . n 
B 1 294 ARG 294 286 ?   ?   ?   B . n 
B 1 295 PRO 295 287 287 PRO PRO B . n 
B 1 296 TRP 296 288 288 TRP TRP B . n 
B 1 297 PRO 297 289 289 PRO PRO B . n 
B 1 298 ALA 298 290 290 ALA ALA B . n 
B 1 299 LEU 299 291 291 LEU LEU B . n 
B 1 300 GLY 300 292 292 GLY GLY B . n 
B 1 301 ARG 301 293 293 ARG ARG B . n 
B 1 302 GLY 302 294 294 GLY GLY B . n 
B 1 303 TYR 303 295 295 TYR TYR B . n 
B 1 304 ASN 304 296 296 ASN ASN B . n 
B 1 305 THR 305 297 297 THR THR B . n 
B 1 306 GLY 306 298 298 GLY GLY B . n 
B 1 307 VAL 307 299 299 VAL VAL B . n 
B 1 308 ILE 308 300 300 ILE ILE B . n 
B 1 309 LEU 309 301 301 LEU LEU B . n 
B 1 310 LEU 310 302 302 LEU LEU B . n 
B 1 311 LEU 311 303 303 LEU LEU B . n 
B 1 312 LEU 312 304 304 LEU LEU B . n 
B 1 313 ASP 313 305 305 ASP ASP B . n 
B 1 314 LYS 314 306 306 LYS LYS B . n 
B 1 315 LEU 315 307 307 LEU LEU B . n 
B 1 316 ARG 316 308 308 ARG ARG B . n 
B 1 317 LYS 317 309 309 LYS LYS B . n 
B 1 318 MET 318 310 310 MET MET B . n 
B 1 319 LYS 319 311 311 LYS LYS B . n 
B 1 320 TRP 320 312 312 TRP TRP B . n 
B 1 321 GLU 321 313 313 GLU GLU B . n 
B 1 322 GLN 322 314 314 GLN GLN B . n 
B 1 323 MET 323 315 315 MET MET B . n 
B 1 324 TRP 324 316 316 TRP TRP B . n 
B 1 325 ARG 325 317 317 ARG ARG B . n 
B 1 326 LEU 326 318 318 LEU LEU B . n 
B 1 327 THR 327 319 319 THR THR B . n 
B 1 328 ALA 328 320 320 ALA ALA B . n 
B 1 329 GLU 329 321 321 GLU GLU B . n 
B 1 330 ARG 330 322 322 ARG ARG B . n 
B 1 331 GLU 331 323 323 GLU GLU B . n 
B 1 332 LEU 332 324 324 LEU LEU B . n 
B 1 333 MET 333 325 325 MET MET B . n 
B 1 334 GLY 334 326 326 GLY GLY B . n 
B 1 335 MET 335 327 327 MET MET B . n 
B 1 336 LEU 336 328 328 LEU LEU B . n 
B 1 337 SER 337 329 329 SER SER B . n 
B 1 338 THR 338 330 330 THR THR B . n 
B 1 339 SER 339 331 331 SER SER B . n 
B 1 340 LEU 340 332 332 LEU LEU B . n 
B 1 341 ALA 341 333 333 ALA ALA B . n 
B 1 342 ASP 342 334 334 ASP ASP B . n 
B 1 343 GLN 343 335 335 GLN GLN B . n 
B 1 344 ASP 344 336 336 ASP ASP B . n 
B 1 345 ILE 345 337 337 ILE ILE B . n 
B 1 346 PHE 346 338 338 PHE PHE B . n 
B 1 347 ASN 347 339 339 ASN ASN B . n 
B 1 348 ALA 348 340 340 ALA ALA B . n 
B 1 349 VAL 349 341 341 VAL VAL B . n 
B 1 350 ILE 350 342 342 ILE ILE B . n 
B 1 351 LYS 351 343 343 LYS LYS B . n 
B 1 352 GLN 352 344 344 GLN GLN B . n 
B 1 353 ASN 353 345 345 ASN ASN B . n 
B 1 354 PRO 354 346 346 PRO PRO B . n 
B 1 355 PHE 355 347 347 PHE PHE B . n 
B 1 356 LEU 356 348 348 LEU LEU B . n 
B 1 357 VAL 357 349 349 VAL VAL B . n 
B 1 358 TYR 358 350 350 TYR TYR B . n 
B 1 359 GLN 359 351 351 GLN GLN B . n 
B 1 360 LEU 360 352 352 LEU LEU B . n 
B 1 361 PRO 361 353 353 PRO PRO B . n 
B 1 362 CYS 362 354 354 CYS CYS B . n 
B 1 363 PHE 363 355 355 PHE PHE B . n 
B 1 364 TRP 364 356 356 TRP TRP B . n 
B 1 365 ASN 365 357 357 ASN ASN B . n 
B 1 366 VAL 366 358 358 VAL VAL B . n 
B 1 367 GLN 367 359 359 GLN GLN B . n 
B 1 368 LEU 368 360 360 LEU LEU B . n 
B 1 369 SER 369 361 361 SER SER B . n 
B 1 370 ASP 370 362 362 ASP ASP B . n 
B 1 371 HIS 371 363 363 HIS HIS B . n 
B 1 372 THR 372 364 364 THR THR B . n 
B 1 373 ARG 373 365 365 ARG ARG B . n 
B 1 374 SER 374 366 366 SER SER B . n 
B 1 375 GLU 375 367 367 GLU GLU B . n 
B 1 376 GLN 376 368 368 GLN GLN B . n 
B 1 377 CYS 377 369 369 CYS CYS B . n 
B 1 378 TYR 378 370 370 TYR TYR B . n 
B 1 379 ARG 379 371 371 ARG ARG B . n 
B 1 380 ASP 380 372 372 ASP ASP B . n 
B 1 381 VAL 381 373 373 VAL VAL B . n 
B 1 382 SER 382 374 374 SER SER B . n 
B 1 383 ASP 383 375 375 ASP ASP B . n 
B 1 384 LEU 384 376 376 LEU LEU B . n 
B 1 385 LYS 385 377 377 LYS LYS B . n 
B 1 386 VAL 386 378 378 VAL VAL B . n 
B 1 387 ILE 387 379 379 ILE ILE B . n 
B 1 388 HIS 388 380 380 HIS HIS B . n 
B 1 389 TRP 389 381 381 TRP TRP B . n 
B 1 390 ASN 390 382 382 ASN ASN B . n 
B 1 391 SER 391 383 383 SER SER B . n 
B 1 392 PRO 392 384 384 PRO PRO B . n 
B 1 393 LYS 393 385 ?   ?   ?   B . n 
B 1 394 LYS 394 386 ?   ?   ?   B . n 
B 1 395 LEU 395 387 ?   ?   ?   B . n 
B 1 396 ARG 396 388 ?   ?   ?   B . n 
B 1 397 VAL 397 389 ?   ?   ?   B . n 
B 1 398 LYS 398 390 ?   ?   ?   B . n 
B 1 399 ASN 399 391 ?   ?   ?   B . n 
B 1 400 LYS 400 392 ?   ?   ?   B . n 
B 1 401 HIS 401 393 ?   ?   ?   B . n 
B 1 402 VAL 402 394 ?   ?   ?   B . n 
B 1 403 GLU 403 395 395 GLU GLU B . n 
B 1 404 PHE 404 396 396 PHE PHE B . n 
B 1 405 PHE 405 397 397 PHE PHE B . n 
B 1 406 ARG 406 398 398 ARG ARG B . n 
B 1 407 ASN 407 399 399 ASN ASN B . n 
B 1 408 LEU 408 400 400 LEU LEU B . n 
B 1 409 TYR 409 401 401 TYR TYR B . n 
B 1 410 LEU 410 402 402 LEU LEU B . n 
B 1 411 THR 411 403 403 THR THR B . n 
B 1 412 PHE 412 404 404 PHE PHE B . n 
B 1 413 LEU 413 405 405 LEU LEU B . n 
B 1 414 GLU 414 406 406 GLU GLU B . n 
B 1 415 TYR 415 407 407 TYR TYR B . n 
B 1 416 ASP 416 408 408 ASP ASP B . n 
B 1 417 GLY 417 409 409 GLY GLY B . n 
B 1 418 ASN 418 410 410 ASN ASN B . n 
B 1 419 LEU 419 411 411 LEU LEU B . n 
B 1 420 LEU 420 412 412 LEU LEU B . n 
B 1 421 ARG 421 413 413 ARG ARG B . n 
B 1 422 ARG 422 414 414 ARG ARG B . n 
B 1 423 GLU 423 415 415 GLU GLU B . n 
B 1 424 LEU 424 416 416 LEU LEU B . n 
B 1 425 PHE 425 417 417 PHE PHE B . n 
B 1 426 GLY 426 418 418 GLY GLY B . n 
B 1 427 CYS 427 419 419 CYS CYS B . n 
B 1 428 PRO 428 420 420 PRO PRO B . n 
B 1 429 SER 429 421 421 SER SER B . n 
B 1 430 GLU 430 422 422 GLU GLU B . n 
B 1 431 ALA 431 423 423 ALA ALA B . n 
B 1 432 ASP 432 424 424 ASP ASP B . n 
B 1 433 VAL 433 425 425 VAL VAL B . n 
B 1 434 ASN 434 426 426 ASN ASN B . n 
B 1 435 SER 435 427 427 SER SER B . n 
B 1 436 GLU 436 428 428 GLU GLU B . n 
B 1 437 ASN 437 429 429 ASN ASN B . n 
B 1 438 LEU 438 430 430 LEU LEU B . n 
B 1 439 GLN 439 431 431 GLN GLN B . n 
B 1 440 LYS 440 432 432 LYS LYS B . n 
B 1 441 GLN 441 433 433 GLN GLN B . n 
B 1 442 LEU 442 434 434 LEU LEU B . n 
B 1 443 SER 443 435 435 SER SER B . n 
B 1 444 GLU 444 436 436 GLU GLU B . n 
B 1 445 LEU 445 437 437 LEU LEU B . n 
B 1 446 ASP 446 438 438 ASP ASP B . n 
B 1 447 GLU 447 439 439 GLU GLU B . n 
B 1 448 ASP 448 440 440 ASP ASP B . n 
B 1 449 ASP 449 441 441 ASP ASP B . n 
B 1 450 LEU 450 442 442 LEU LEU B . n 
B 1 451 CYS 451 443 443 CYS CYS B . n 
B 1 452 TYR 452 444 444 TYR TYR B . n 
B 1 453 GLU 453 445 445 GLU GLU B . n 
B 1 454 PHE 454 446 446 PHE PHE B . n 
B 1 455 ARG 455 447 447 ARG ARG B . n 
B 1 456 ARG 456 448 448 ARG ARG B . n 
B 1 457 GLU 457 449 449 GLU GLU B . n 
B 1 458 ARG 458 450 450 ARG ARG B . n 
B 1 459 PHE 459 451 451 PHE PHE B . n 
B 1 460 THR 460 452 452 THR THR B . n 
B 1 461 VAL 461 453 453 VAL VAL B . n 
B 1 462 HIS 462 454 454 HIS HIS B . n 
B 1 463 ARG 463 455 455 ARG ARG B . n 
B 1 464 THR 464 456 456 THR THR B . n 
B 1 465 HIS 465 457 457 HIS HIS B . n 
B 1 466 LEU 466 458 458 LEU LEU B . n 
B 1 467 TYR 467 459 459 TYR TYR B . n 
B 1 468 PHE 468 460 460 PHE PHE B . n 
B 1 469 LEU 469 461 461 LEU LEU B . n 
B 1 470 HIS 470 462 462 HIS HIS B . n 
B 1 471 TYR 471 463 463 TYR TYR B . n 
B 1 472 GLU 472 464 464 GLU GLU B . n 
B 1 473 TYR 473 465 465 TYR TYR B . n 
B 1 474 GLU 474 466 466 GLU GLU B . n 
B 1 475 PRO 475 467 467 PRO PRO B . n 
B 1 476 ALA 476 468 468 ALA ALA B . n 
B 1 477 ALA 477 469 469 ALA ALA B . n 
B 1 478 ASP 478 470 470 ASP ASP B . n 
B 1 479 SER 479 471 471 SER SER B . n 
B 1 480 THR 480 472 472 THR THR B . n 
B 1 481 ASP 481 473 473 ASP ASP B . n 
B 1 482 VAL 482 474 474 VAL VAL B . n 
B 1 483 THR 483 475 475 THR THR B . n 
B 1 484 LEU 484 476 476 LEU LEU B . n 
B 1 485 VAL 485 477 477 VAL VAL B . n 
B 1 486 ALA 486 478 478 ALA ALA B . n 
B 1 487 GLN 487 479 479 GLN GLN B . n 
B 1 488 LEU 488 480 480 LEU LEU B . n 
B 1 489 SER 489 481 481 SER SER B . n 
B 1 490 MET 490 482 482 MET MET B . n 
B 1 491 ASP 491 483 483 ASP ASP B . n 
B 1 492 ARG 492 484 484 ARG ARG B . n 
B 1 493 LEU 493 485 485 LEU LEU B . n 
B 1 494 GLN 494 486 486 GLN GLN B . n 
B 1 495 MET 495 487 487 MET MET B . n 
B 1 496 LEU 496 488 488 LEU LEU B . n 
B 1 497 GLU 497 489 489 GLU GLU B . n 
B 1 498 ALA 498 490 490 ALA ALA B . n 
B 1 499 ILE 499 491 491 ILE ILE B . n 
B 1 500 CYS 500 492 492 CYS CYS B . n 
B 1 501 LYS 501 493 493 LYS LYS B . n 
B 1 502 HIS 502 494 494 HIS HIS B . n 
B 1 503 TRP 503 495 495 TRP TRP B . n 
B 1 504 GLU 504 496 496 GLU GLU B . n 
B 1 505 GLY 505 497 497 GLY GLY B . n 
B 1 506 PRO 506 498 498 PRO PRO B . n 
B 1 507 ILE 507 499 499 ILE ILE B . n 
B 1 508 SER 508 500 500 SER SER B . n 
B 1 509 LEU 509 501 501 LEU LEU B . n 
B 1 510 ALA 510 502 502 ALA ALA B . n 
B 1 511 LEU 511 503 503 LEU LEU B . n 
B 1 512 TYR 512 504 504 TYR TYR B . n 
B 1 513 LEU 513 505 505 LEU LEU B . n 
B 1 514 SER 514 506 506 SER SER B . n 
B 1 515 ASP 515 507 507 ASP ASP B . n 
B 1 516 ALA 516 508 508 ALA ALA B . n 
B 1 517 GLU 517 509 509 GLU GLU B . n 
B 1 518 ALA 518 510 510 ALA ALA B . n 
B 1 519 GLN 519 511 511 GLN GLN B . n 
B 1 520 GLN 520 512 512 GLN GLN B . n 
B 1 521 PHE 521 513 513 PHE PHE B . n 
B 1 522 LEU 522 514 514 LEU LEU B . n 
B 1 523 ARG 523 515 515 ARG ARG B . n 
B 1 524 TYR 524 516 516 TYR TYR B . n 
B 1 525 ALA 525 517 517 ALA ALA B . n 
B 1 526 GLN 526 518 518 GLN GLN B . n 
B 1 527 GLY 527 519 519 GLY GLY B . n 
B 1 528 SER 528 520 520 SER SER B . n 
B 1 529 GLU 529 521 521 GLU GLU B . n 
B 1 530 VAL 530 522 522 VAL VAL B . n 
B 1 531 LEU 531 523 523 LEU LEU B . n 
B 1 532 MET 532 524 524 MET MET B . n 
B 1 533 SER 533 525 525 SER SER B . n 
B 1 534 ARG 534 526 526 ARG ARG B . n 
B 1 535 HIS 535 527 527 HIS HIS B . n 
B 1 536 ASN 536 528 528 ASN ASN B . n 
B 1 537 VAL 537 529 529 VAL VAL B . n 
B 1 538 GLY 538 530 530 GLY GLY B . n 
B 1 539 TYR 539 531 531 TYR TYR B . n 
B 1 540 HIS 540 532 532 HIS HIS B . n 
B 1 541 ILE 541 533 533 ILE ILE B . n 
B 1 542 VAL 542 534 534 VAL VAL B . n 
B 1 543 TYR 543 535 535 TYR TYR B . n 
B 1 544 LYS 544 536 536 LYS LYS B . n 
B 1 545 GLU 545 537 537 GLU GLU B . n 
B 1 546 GLY 546 538 538 GLY GLY B . n 
B 1 547 GLN 547 539 539 GLN GLN B . n 
B 1 548 PHE 548 540 540 PHE PHE B . n 
B 1 549 TYR 549 541 541 TYR TYR B . n 
B 1 550 PRO 550 542 542 PRO PRO B . n 
B 1 551 VAL 551 543 543 VAL VAL B . n 
B 1 552 ASN 552 544 544 ASN ASN B . n 
B 1 553 LEU 553 545 545 LEU LEU B . n 
B 1 554 LEU 554 546 546 LEU LEU B . n 
B 1 555 ARG 555 547 547 ARG ARG B . n 
B 1 556 ASN 556 548 548 ASN ASN B . n 
B 1 557 VAL 557 549 549 VAL VAL B . n 
B 1 558 ALA 558 550 550 ALA ALA B . n 
B 1 559 MET 559 551 551 MET MET B . n 
B 1 560 LYS 560 552 552 LYS LYS B . n 
B 1 561 HIS 561 553 553 HIS HIS B . n 
B 1 562 ILE 562 554 554 ILE ILE B . n 
B 1 563 SER 563 555 555 SER SER B . n 
B 1 564 THR 564 556 556 THR THR B . n 
B 1 565 PRO 565 557 557 PRO PRO B . n 
B 1 566 TYR 566 558 558 TYR TYR B . n 
B 1 567 MET 567 559 559 MET MET B . n 
B 1 568 PHE 568 560 560 PHE PHE B . n 
B 1 569 LEU 569 561 561 LEU LEU B . n 
B 1 570 SER 570 562 562 SER SER B . n 
B 1 571 ASP 571 563 563 ASP ASP B . n 
B 1 572 ILE 572 564 564 ILE ILE B . n 
B 1 573 ASP 573 565 565 ASP ASP B . n 
B 1 574 PHE 574 566 566 PHE PHE B . n 
B 1 575 LEU 575 567 567 LEU LEU B . n 
B 1 576 PRO 576 568 568 PRO PRO B . n 
B 1 577 MET 577 569 569 MET MET B . n 
B 1 578 TYR 578 570 570 TYR TYR B . n 
B 1 579 GLY 579 571 571 GLY GLY B . n 
B 1 580 LEU 580 572 572 LEU LEU B . n 
B 1 581 TYR 581 573 573 TYR TYR B . n 
B 1 582 GLU 582 574 574 GLU GLU B . n 
B 1 583 TYR 583 575 575 TYR TYR B . n 
B 1 584 LEU 584 576 576 LEU LEU B . n 
B 1 585 ARG 585 577 577 ARG ARG B . n 
B 1 586 LYS 586 578 578 LYS LYS B . n 
B 1 587 SER 587 579 579 SER SER B . n 
B 1 588 VAL 588 580 580 VAL VAL B . n 
B 1 589 ILE 589 581 581 ILE ILE B . n 
B 1 590 GLN 590 582 582 GLN GLN B . n 
B 1 591 LEU 591 583 583 LEU LEU B . n 
B 1 592 ASP 592 584 584 ASP ASP B . n 
B 1 593 LEU 593 585 585 LEU LEU B . n 
B 1 594 ALA 594 586 586 ALA ALA B . n 
B 1 595 ASN 595 587 587 ASN ASN B . n 
B 1 596 THR 596 588 588 THR THR B . n 
B 1 597 LYS 597 589 589 LYS LYS B . n 
B 1 598 LYS 598 590 590 LYS LYS B . n 
B 1 599 ALA 599 591 591 ALA ALA B . n 
B 1 600 MET 600 592 592 MET MET B . n 
B 1 601 ILE 601 593 593 ILE ILE B . n 
B 1 602 VAL 602 594 594 VAL VAL B . n 
B 1 603 PRO 603 595 595 PRO PRO B . n 
B 1 604 ALA 604 596 596 ALA ALA B . n 
B 1 605 PHE 605 597 597 PHE PHE B . n 
B 1 606 GLU 606 598 598 GLU GLU B . n 
B 1 607 THR 607 599 599 THR THR B . n 
B 1 608 LEU 608 600 600 LEU LEU B . n 
B 1 609 ARG 609 601 601 ARG ARG B . n 
B 1 610 TYR 610 602 602 TYR TYR B . n 
B 1 611 ARG 611 603 603 ARG ARG B . n 
B 1 612 LEU 612 604 604 LEU LEU B . n 
B 1 613 SER 613 605 605 SER SER B . n 
B 1 614 PHE 614 606 606 PHE PHE B . n 
B 1 615 PRO 615 607 607 PRO PRO B . n 
B 1 616 LYS 616 608 608 LYS LYS B . n 
B 1 617 SER 617 609 609 SER SER B . n 
B 1 618 LYS 618 610 610 LYS LYS B . n 
B 1 619 ALA 619 611 611 ALA ALA B . n 
B 1 620 GLU 620 612 612 GLU GLU B . n 
B 1 621 LEU 621 613 613 LEU LEU B . n 
B 1 622 LEU 622 614 614 LEU LEU B . n 
B 1 623 SER 623 615 615 SER SER B . n 
B 1 624 MET 624 616 616 MET MET B . n 
B 1 625 LEU 625 617 617 LEU LEU B . n 
B 1 626 ASP 626 618 618 ASP ASP B . n 
B 1 627 MET 627 619 619 MET MET B . n 
B 1 628 GLY 628 620 620 GLY GLY B . n 
B 1 629 THR 629 621 621 THR THR B . n 
B 1 630 LEU 630 622 622 LEU LEU B . n 
B 1 631 PHE 631 623 623 PHE PHE B . n 
B 1 632 THR 632 624 624 THR THR B . n 
B 1 633 PHE 633 625 625 PHE PHE B . n 
B 1 634 ARG 634 626 626 ARG ARG B . n 
B 1 635 TYR 635 627 627 TYR TYR B . n 
B 1 636 HIS 636 628 628 HIS HIS B . n 
B 1 637 VAL 637 629 629 VAL VAL B . n 
B 1 638 TRP 638 630 630 TRP TRP B . n 
B 1 639 THR 639 631 631 THR THR B . n 
B 1 640 LYS 640 632 632 LYS LYS B . n 
B 1 641 GLY 641 633 633 GLY GLY B . n 
B 1 642 HIS 642 634 634 HIS HIS B . n 
B 1 643 ALA 643 635 635 ALA ALA B . n 
B 1 644 PRO 644 636 636 PRO PRO B . n 
B 1 645 THR 645 637 637 THR THR B . n 
B 1 646 ASN 646 638 638 ASN ASN B . n 
B 1 647 PHE 647 639 639 PHE PHE B . n 
B 1 648 ALA 648 640 640 ALA ALA B . n 
B 1 649 LYS 649 641 641 LYS LYS B . n 
B 1 650 TRP 650 642 642 TRP TRP B . n 
B 1 651 ARG 651 643 643 ARG ARG B . n 
B 1 652 THR 652 644 644 THR THR B . n 
B 1 653 ALA 653 645 645 ALA ALA B . n 
B 1 654 THR 654 646 646 THR THR B . n 
B 1 655 THR 655 647 647 THR THR B . n 
B 1 656 PRO 656 648 648 PRO PRO B . n 
B 1 657 TYR 657 649 649 TYR TYR B . n 
B 1 658 ARG 658 650 650 ARG ARG B . n 
B 1 659 VAL 659 651 651 VAL VAL B . n 
B 1 660 GLU 660 652 652 GLU GLU B . n 
B 1 661 TRP 661 653 653 TRP TRP B . n 
B 1 662 GLU 662 654 654 GLU GLU B . n 
B 1 663 ALA 663 655 655 ALA ALA B . n 
B 1 664 ASP 664 656 656 ASP ASP B . n 
B 1 665 PHE 665 657 657 PHE PHE B . n 
B 1 666 GLU 666 658 658 GLU GLU B . n 
B 1 667 PRO 667 659 659 PRO PRO B . n 
B 1 668 TYR 668 660 660 TYR TYR B . n 
B 1 669 VAL 669 661 661 VAL VAL B . n 
B 1 670 VAL 670 662 662 VAL VAL B . n 
B 1 671 VAL 671 663 663 VAL VAL B . n 
B 1 672 ARG 672 664 664 ARG ARG B . n 
B 1 673 ARG 673 665 665 ARG ARG B . n 
B 1 674 ASP 674 666 666 ASP ASP B . n 
B 1 675 CYS 675 667 667 CYS CYS B . n 
B 1 676 PRO 676 668 668 PRO PRO B . n 
B 1 677 GLU 677 669 669 GLU GLU B . n 
B 1 678 TYR 678 670 670 TYR TYR B . n 
B 1 679 ASP 679 671 671 ASP ASP B . n 
B 1 680 ARG 680 672 672 ARG ARG B . n 
B 1 681 ARG 681 673 673 ARG ARG B . n 
B 1 682 PHE 682 674 674 PHE PHE B . n 
B 1 683 VAL 683 675 675 VAL VAL B . n 
B 1 684 GLY 684 676 676 GLY GLY B . n 
B 1 685 PHE 685 677 677 PHE PHE B . n 
B 1 686 GLY 686 678 678 GLY GLY B . n 
B 1 687 TRP 687 679 679 TRP TRP B . n 
B 1 688 ASN 688 680 680 ASN ASN B . n 
B 1 689 LYS 689 681 681 LYS LYS B . n 
B 1 690 VAL 690 682 682 VAL VAL B . n 
B 1 691 ALA 691 683 683 ALA ALA B . n 
B 1 692 HIS 692 684 684 HIS HIS B . n 
B 1 693 ILE 693 685 685 ILE ILE B . n 
B 1 694 MET 694 686 686 MET MET B . n 
B 1 695 GLU 695 687 687 GLU GLU B . n 
B 1 696 LEU 696 688 688 LEU LEU B . n 
B 1 697 ASP 697 689 689 ASP ASP B . n 
B 1 698 VAL 698 690 690 VAL VAL B . n 
B 1 699 GLN 699 691 691 GLN GLN B . n 
B 1 700 GLU 700 692 692 GLU GLU B . n 
B 1 701 TYR 701 693 693 TYR TYR B . n 
B 1 702 GLU 702 694 694 GLU GLU B . n 
B 1 703 PHE 703 695 695 PHE PHE B . n 
B 1 704 ILE 704 696 696 ILE ILE B . n 
B 1 705 VAL 705 697 697 VAL VAL B . n 
B 1 706 LEU 706 698 698 LEU LEU B . n 
B 1 707 PRO 707 699 699 PRO PRO B . n 
B 1 708 ASN 708 700 700 ASN ASN B . n 
B 1 709 ALA 709 701 701 ALA ALA B . n 
B 1 710 TYR 710 702 702 TYR TYR B . n 
B 1 711 MET 711 703 703 MET MET B . n 
B 1 712 ILE 712 704 704 ILE ILE B . n 
B 1 713 HIS 713 705 705 HIS HIS B . n 
B 1 714 MET 714 706 706 MET MET B . n 
B 1 715 PRO 715 707 707 PRO PRO B . n 
B 1 716 HIS 716 708 708 HIS HIS B . n 
B 1 717 ALA 717 709 709 ALA ALA B . n 
B 1 718 PRO 718 710 710 PRO PRO B . n 
B 1 719 SER 719 711 711 SER SER B . n 
B 1 720 PHE 720 712 712 PHE PHE B . n 
B 1 721 ASP 721 713 713 ASP ASP B . n 
B 1 722 ILE 722 714 714 ILE ILE B . n 
B 1 723 THR 723 715 715 THR THR B . n 
B 1 724 LYS 724 716 716 LYS LYS B . n 
B 1 725 PHE 725 717 717 PHE PHE B . n 
B 1 726 ARG 726 718 718 ARG ARG B . n 
B 1 727 SER 727 719 719 SER SER B . n 
B 1 728 ASN 728 720 720 ASN ASN B . n 
B 1 729 LYS 729 721 721 LYS LYS B . n 
B 1 730 GLN 730 722 722 GLN GLN B . n 
B 1 731 TYR 731 723 723 TYR TYR B . n 
B 1 732 ARG 732 724 724 ARG ARG B . n 
B 1 733 ILE 733 725 725 ILE ILE B . n 
B 1 734 CYS 734 726 726 CYS CYS B . n 
B 1 735 LEU 735 727 727 LEU LEU B . n 
B 1 736 LYS 736 728 728 LYS LYS B . n 
B 1 737 THR 737 729 729 THR THR B . n 
B 1 738 LEU 738 730 730 LEU LEU B . n 
B 1 739 LYS 739 731 731 LYS LYS B . n 
B 1 740 GLU 740 732 732 GLU GLU B . n 
B 1 741 GLU 741 733 733 GLU GLU B . n 
B 1 742 PHE 742 734 734 PHE PHE B . n 
B 1 743 GLN 743 735 735 GLN GLN B . n 
B 1 744 GLN 744 736 736 GLN GLN B . n 
B 1 745 ASP 745 737 737 ASP ASP B . n 
B 1 746 MET 746 738 738 MET MET B . n 
B 1 747 SER 747 739 739 SER SER B . n 
B 1 748 ARG 748 740 740 ARG ARG B . n 
B 1 749 ARG 749 741 741 ARG ARG B . n 
B 1 750 TYR 750 742 742 TYR TYR B . n 
B 1 751 GLY 751 743 743 GLY GLY B . n 
B 1 752 PHE 752 744 744 PHE PHE B . n 
B 1 753 ALA 753 745 745 ALA ALA B . n 
B 1 754 ALA 754 746 746 ALA ALA B . n 
B 1 755 LEU 755 747 747 LEU LEU B . n 
B 1 756 LYS 756 748 748 LYS LYS B . n 
B 1 757 TYR 757 749 749 TYR TYR B . n 
B 1 758 LEU 758 750 750 LEU LEU B . n 
B 1 759 THR 759 751 751 THR THR B . n 
B 1 760 ALA 760 752 752 ALA ALA B . n 
B 1 761 GLU 761 753 ?   ?   ?   B . n 
B 1 762 ASN 762 754 ?   ?   ?   B . n 
B 1 763 ASN 763 755 ?   ?   ?   B . n 
B 1 764 SER 764 756 ?   ?   ?   B . n 
B 1 765 HIS 765 757 ?   ?   ?   B . n 
B 1 766 HIS 766 758 ?   ?   ?   B . n 
B 1 767 HIS 767 759 ?   ?   ?   B . n 
B 1 768 HIS 768 760 ?   ?   ?   B . n 
B 1 769 HIS 769 761 ?   ?   ?   B . n 
B 1 770 HIS 770 762 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 MN  ? ? MN  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 UDP ? ? UDP ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 MN  1 900 900 MN  MN  A . 
D 3 UDP 1 901 901 UDP UDP A . 
E 2 MN  1 801 902 MN  MN  B . 
F 3 UDP 1 802 903 UDP UDP B . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9E1T 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9E1T 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9E1T 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9E1T 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002 ? 10306 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.360 ? 13988 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 8.280 ? 3748  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.038 ? 1510  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.003 ? 1760  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9E1T 
_struct.title                        'CryoEM structure of LARGE1 bound to UDP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9E1T 
_struct_keywords.text            'Glycosyltransferase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LARG1_HUMAN 
_struct_ref.pdbx_db_accession          O95461 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;FEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSEN
LRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPA
VRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQ
SDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLP
CFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQ
LSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQF
LRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMI
VPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRR
FVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAE
NNS
;
_struct_ref.pdbx_align_begin           34 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9E1T A 42 ? 764 ? O95461 34 ? 756 ? 34 756 
2 1 9E1T B 42 ? 764 ? O95461 34 ? 756 ? 34 756 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9E1T MET A 1   ? UNP O95461 ? ? 'initiating methionine' -7  1  
1 9E1T SER A 2   ? UNP O95461 ? ? 'expression tag'        -6  2  
1 9E1T ALA A 3   ? UNP O95461 ? ? 'expression tag'        -5  3  
1 9E1T LEU A 4   ? UNP O95461 ? ? 'expression tag'        -4  4  
1 9E1T LEU A 5   ? UNP O95461 ? ? 'expression tag'        -3  5  
1 9E1T ILE A 6   ? UNP O95461 ? ? 'expression tag'        -2  6  
1 9E1T LEU A 7   ? UNP O95461 ? ? 'expression tag'        -1  7  
1 9E1T ALA A 8   ? UNP O95461 ? ? 'expression tag'        0   8  
1 9E1T LEU A 9   ? UNP O95461 ? ? 'expression tag'        1   9  
1 9E1T VAL A 10  ? UNP O95461 ? ? 'expression tag'        2   10 
1 9E1T GLY A 11  ? UNP O95461 ? ? 'expression tag'        3   11 
1 9E1T ALA A 12  ? UNP O95461 ? ? 'expression tag'        4   12 
1 9E1T ALA A 13  ? UNP O95461 ? ? 'expression tag'        5   13 
1 9E1T VAL A 14  ? UNP O95461 ? ? 'expression tag'        6   14 
1 9E1T ALA A 15  ? UNP O95461 ? ? 'expression tag'        7   15 
1 9E1T ASP A 16  ? UNP O95461 ? ? 'expression tag'        8   16 
1 9E1T TYR A 17  ? UNP O95461 ? ? 'expression tag'        9   17 
1 9E1T LYS A 18  ? UNP O95461 ? ? 'expression tag'        10  18 
1 9E1T ASP A 19  ? UNP O95461 ? ? 'expression tag'        11  19 
1 9E1T HIS A 20  ? UNP O95461 ? ? 'expression tag'        12  20 
1 9E1T ASP A 21  ? UNP O95461 ? ? 'expression tag'        13  21 
1 9E1T GLY A 22  ? UNP O95461 ? ? 'expression tag'        14  22 
1 9E1T ASP A 23  ? UNP O95461 ? ? 'expression tag'        15  23 
1 9E1T TYR A 24  ? UNP O95461 ? ? 'expression tag'        16  24 
1 9E1T LYS A 25  ? UNP O95461 ? ? 'expression tag'        17  25 
1 9E1T ASP A 26  ? UNP O95461 ? ? 'expression tag'        18  26 
1 9E1T HIS A 27  ? UNP O95461 ? ? 'expression tag'        19  27 
1 9E1T ASP A 28  ? UNP O95461 ? ? 'expression tag'        20  28 
1 9E1T ILE A 29  ? UNP O95461 ? ? 'expression tag'        21  29 
1 9E1T ASP A 30  ? UNP O95461 ? ? 'expression tag'        22  30 
1 9E1T TYR A 31  ? UNP O95461 ? ? 'expression tag'        23  31 
1 9E1T LYS A 32  ? UNP O95461 ? ? 'expression tag'        24  32 
1 9E1T ASP A 33  ? UNP O95461 ? ? 'expression tag'        25  33 
1 9E1T ASP A 34  ? UNP O95461 ? ? 'expression tag'        26  34 
1 9E1T ASP A 35  ? UNP O95461 ? ? 'expression tag'        27  35 
1 9E1T ASP A 36  ? UNP O95461 ? ? 'expression tag'        28  36 
1 9E1T LYS A 37  ? UNP O95461 ? ? 'expression tag'        29  37 
1 9E1T LEU A 38  ? UNP O95461 ? ? 'expression tag'        30  38 
1 9E1T ALA A 39  ? UNP O95461 ? ? 'expression tag'        31  39 
1 9E1T ALA A 40  ? UNP O95461 ? ? 'expression tag'        32  40 
1 9E1T ALA A 41  ? UNP O95461 ? ? 'expression tag'        33  41 
1 9E1T HIS A 765 ? UNP O95461 ? ? 'expression tag'        757 42 
1 9E1T HIS A 766 ? UNP O95461 ? ? 'expression tag'        758 43 
1 9E1T HIS A 767 ? UNP O95461 ? ? 'expression tag'        759 44 
1 9E1T HIS A 768 ? UNP O95461 ? ? 'expression tag'        760 45 
1 9E1T HIS A 769 ? UNP O95461 ? ? 'expression tag'        761 46 
1 9E1T HIS A 770 ? UNP O95461 ? ? 'expression tag'        762 47 
2 9E1T MET B 1   ? UNP O95461 ? ? 'initiating methionine' -7  48 
2 9E1T SER B 2   ? UNP O95461 ? ? 'expression tag'        -6  49 
2 9E1T ALA B 3   ? UNP O95461 ? ? 'expression tag'        -5  50 
2 9E1T LEU B 4   ? UNP O95461 ? ? 'expression tag'        -4  51 
2 9E1T LEU B 5   ? UNP O95461 ? ? 'expression tag'        -3  52 
2 9E1T ILE B 6   ? UNP O95461 ? ? 'expression tag'        -2  53 
2 9E1T LEU B 7   ? UNP O95461 ? ? 'expression tag'        -1  54 
2 9E1T ALA B 8   ? UNP O95461 ? ? 'expression tag'        0   55 
2 9E1T LEU B 9   ? UNP O95461 ? ? 'expression tag'        1   56 
2 9E1T VAL B 10  ? UNP O95461 ? ? 'expression tag'        2   57 
2 9E1T GLY B 11  ? UNP O95461 ? ? 'expression tag'        3   58 
2 9E1T ALA B 12  ? UNP O95461 ? ? 'expression tag'        4   59 
2 9E1T ALA B 13  ? UNP O95461 ? ? 'expression tag'        5   60 
2 9E1T VAL B 14  ? UNP O95461 ? ? 'expression tag'        6   61 
2 9E1T ALA B 15  ? UNP O95461 ? ? 'expression tag'        7   62 
2 9E1T ASP B 16  ? UNP O95461 ? ? 'expression tag'        8   63 
2 9E1T TYR B 17  ? UNP O95461 ? ? 'expression tag'        9   64 
2 9E1T LYS B 18  ? UNP O95461 ? ? 'expression tag'        10  65 
2 9E1T ASP B 19  ? UNP O95461 ? ? 'expression tag'        11  66 
2 9E1T HIS B 20  ? UNP O95461 ? ? 'expression tag'        12  67 
2 9E1T ASP B 21  ? UNP O95461 ? ? 'expression tag'        13  68 
2 9E1T GLY B 22  ? UNP O95461 ? ? 'expression tag'        14  69 
2 9E1T ASP B 23  ? UNP O95461 ? ? 'expression tag'        15  70 
2 9E1T TYR B 24  ? UNP O95461 ? ? 'expression tag'        16  71 
2 9E1T LYS B 25  ? UNP O95461 ? ? 'expression tag'        17  72 
2 9E1T ASP B 26  ? UNP O95461 ? ? 'expression tag'        18  73 
2 9E1T HIS B 27  ? UNP O95461 ? ? 'expression tag'        19  74 
2 9E1T ASP B 28  ? UNP O95461 ? ? 'expression tag'        20  75 
2 9E1T ILE B 29  ? UNP O95461 ? ? 'expression tag'        21  76 
2 9E1T ASP B 30  ? UNP O95461 ? ? 'expression tag'        22  77 
2 9E1T TYR B 31  ? UNP O95461 ? ? 'expression tag'        23  78 
2 9E1T LYS B 32  ? UNP O95461 ? ? 'expression tag'        24  79 
2 9E1T ASP B 33  ? UNP O95461 ? ? 'expression tag'        25  80 
2 9E1T ASP B 34  ? UNP O95461 ? ? 'expression tag'        26  81 
2 9E1T ASP B 35  ? UNP O95461 ? ? 'expression tag'        27  82 
2 9E1T ASP B 36  ? UNP O95461 ? ? 'expression tag'        28  83 
2 9E1T LYS B 37  ? UNP O95461 ? ? 'expression tag'        29  84 
2 9E1T LEU B 38  ? UNP O95461 ? ? 'expression tag'        30  85 
2 9E1T ALA B 39  ? UNP O95461 ? ? 'expression tag'        31  86 
2 9E1T ALA B 40  ? UNP O95461 ? ? 'expression tag'        32  87 
2 9E1T ALA B 41  ? UNP O95461 ? ? 'expression tag'        33  88 
2 9E1T HIS B 765 ? UNP O95461 ? ? 'expression tag'        757 89 
2 9E1T HIS B 766 ? UNP O95461 ? ? 'expression tag'        758 90 
2 9E1T HIS B 767 ? UNP O95461 ? ? 'expression tag'        759 91 
2 9E1T HIS B 768 ? UNP O95461 ? ? 'expression tag'        760 92 
2 9E1T HIS B 769 ? UNP O95461 ? ? 'expression tag'        761 93 
2 9E1T HIS B 770 ? UNP O95461 ? ? 'expression tag'        762 94 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 154 ? ARG A 172 ? GLY A 146 ARG A 164 1 ? 19 
HELX_P HELX_P2  AA2 ASP A 183 ? MET A 198 ? ASP A 175 MET A 190 1 ? 16 
HELX_P HELX_P3  AA3 LEU A 212 ? SER A 217 ? LEU A 204 SER A 209 1 ? 6  
HELX_P HELX_P4  AA4 SER A 225 ? LEU A 233 ? SER A 217 LEU A 225 5 ? 9  
HELX_P HELX_P5  AA5 VAL A 234 ? LEU A 239 ? VAL A 226 LEU A 231 1 ? 6  
HELX_P HELX_P6  AA6 ASP A 258 ? VAL A 265 ? ASP A 250 VAL A 257 1 ? 8  
HELX_P HELX_P7  AA7 PHE A 266 ? PHE A 269 ? PHE A 258 PHE A 261 5 ? 4  
HELX_P HELX_P8  AA8 LEU A 312 ? MET A 318 ? LEU A 304 MET A 310 1 ? 7  
HELX_P HELX_P9  AA9 LYS A 319 ? LEU A 336 ? LYS A 311 LEU A 328 1 ? 18 
HELX_P HELX_P10 AB1 ALA A 341 ? ASN A 353 ? ALA A 333 ASN A 345 1 ? 13 
HELX_P HELX_P11 AB2 PRO A 361 ? ASN A 365 ? PRO A 353 ASN A 357 5 ? 5  
HELX_P HELX_P12 AB3 ASP A 380 ? LEU A 384 ? ASP A 372 LEU A 376 5 ? 5  
HELX_P HELX_P13 AB4 PHE A 404 ? GLU A 414 ? PHE A 396 GLU A 406 1 ? 11 
HELX_P HELX_P14 AB5 ASP A 416 ? ARG A 421 ? ASP A 408 ARG A 413 5 ? 6  
HELX_P HELX_P15 AB6 ASP A 432 ? LEU A 445 ? ASP A 424 LEU A 437 1 ? 14 
HELX_P HELX_P16 AB7 CYS A 451 ? THR A 460 ? CYS A 443 THR A 452 1 ? 10 
HELX_P HELX_P17 AB8 SER A 489 ? ASP A 491 ? SER A 481 ASP A 483 5 ? 3  
HELX_P HELX_P18 AB9 ARG A 492 ? TRP A 503 ? ARG A 484 TRP A 495 1 ? 12 
HELX_P HELX_P19 AC1 SER A 514 ? GLY A 527 ? SER A 506 GLY A 519 1 ? 14 
HELX_P HELX_P20 AC2 SER A 528 ? ARG A 534 ? SER A 520 ARG A 526 1 ? 7  
HELX_P HELX_P21 AC3 PRO A 550 ? HIS A 561 ? PRO A 542 HIS A 553 1 ? 12 
HELX_P HELX_P22 AC4 GLY A 579 ? ASP A 592 ? GLY A 571 ASP A 584 1 ? 14 
HELX_P HELX_P23 AC5 SER A 617 ? MET A 627 ? SER A 609 MET A 619 1 ? 11 
HELX_P HELX_P24 AC6 TRP A 638 ? THR A 645 ? TRP A 630 THR A 637 5 ? 8  
HELX_P HELX_P25 AC7 ASN A 646 ? ALA A 653 ? ASN A 638 ALA A 645 1 ? 8  
HELX_P HELX_P26 AC8 TRP A 687 ? GLN A 699 ? TRP A 679 GLN A 691 1 ? 13 
HELX_P HELX_P27 AC9 SER A 719 ? PHE A 725 ? SER A 711 PHE A 717 1 ? 7  
HELX_P HELX_P28 AD1 LYS A 729 ? GLY A 751 ? LYS A 721 GLY A 743 1 ? 23 
HELX_P HELX_P29 AD2 PHE A 752 ? LEU A 758 ? PHE A 744 LEU A 750 5 ? 7  
HELX_P HELX_P30 AD3 GLY B 154 ? ARG B 172 ? GLY B 146 ARG B 164 1 ? 19 
HELX_P HELX_P31 AD4 ASP B 183 ? MET B 198 ? ASP B 175 MET B 190 1 ? 16 
HELX_P HELX_P32 AD5 LEU B 212 ? SER B 217 ? LEU B 204 SER B 209 1 ? 6  
HELX_P HELX_P33 AD6 SER B 225 ? LEU B 233 ? SER B 217 LEU B 225 5 ? 9  
HELX_P HELX_P34 AD7 VAL B 234 ? LEU B 239 ? VAL B 226 LEU B 231 1 ? 6  
HELX_P HELX_P35 AD8 ASP B 258 ? VAL B 265 ? ASP B 250 VAL B 257 1 ? 8  
HELX_P HELX_P36 AD9 PHE B 266 ? PHE B 269 ? PHE B 258 PHE B 261 5 ? 4  
HELX_P HELX_P37 AE1 LEU B 312 ? MET B 318 ? LEU B 304 MET B 310 1 ? 7  
HELX_P HELX_P38 AE2 LYS B 319 ? LEU B 336 ? LYS B 311 LEU B 328 1 ? 18 
HELX_P HELX_P39 AE3 ALA B 341 ? ASN B 353 ? ALA B 333 ASN B 345 1 ? 13 
HELX_P HELX_P40 AE4 PRO B 361 ? ASN B 365 ? PRO B 353 ASN B 357 5 ? 5  
HELX_P HELX_P41 AE5 ASP B 380 ? LEU B 384 ? ASP B 372 LEU B 376 5 ? 5  
HELX_P HELX_P42 AE6 PHE B 404 ? GLU B 414 ? PHE B 396 GLU B 406 1 ? 11 
HELX_P HELX_P43 AE7 ASP B 416 ? ARG B 421 ? ASP B 408 ARG B 413 5 ? 6  
HELX_P HELX_P44 AE8 ASP B 432 ? LEU B 445 ? ASP B 424 LEU B 437 1 ? 14 
HELX_P HELX_P45 AE9 CYS B 451 ? THR B 460 ? CYS B 443 THR B 452 1 ? 10 
HELX_P HELX_P46 AF1 SER B 489 ? ASP B 491 ? SER B 481 ASP B 483 5 ? 3  
HELX_P HELX_P47 AF2 ARG B 492 ? TRP B 503 ? ARG B 484 TRP B 495 1 ? 12 
HELX_P HELX_P48 AF3 SER B 514 ? GLY B 527 ? SER B 506 GLY B 519 1 ? 14 
HELX_P HELX_P49 AF4 SER B 528 ? ARG B 534 ? SER B 520 ARG B 526 1 ? 7  
HELX_P HELX_P50 AF5 PRO B 550 ? HIS B 561 ? PRO B 542 HIS B 553 1 ? 12 
HELX_P HELX_P51 AF6 GLY B 579 ? ASP B 592 ? GLY B 571 ASP B 584 1 ? 14 
HELX_P HELX_P52 AF7 SER B 617 ? MET B 627 ? SER B 609 MET B 619 1 ? 11 
HELX_P HELX_P53 AF8 TRP B 638 ? THR B 645 ? TRP B 630 THR B 637 5 ? 8  
HELX_P HELX_P54 AF9 ASN B 646 ? ALA B 653 ? ASN B 638 ALA B 645 1 ? 8  
HELX_P HELX_P55 AG1 TRP B 687 ? GLN B 699 ? TRP B 679 GLN B 691 1 ? 13 
HELX_P HELX_P56 AG2 SER B 719 ? PHE B 725 ? SER B 711 PHE B 717 1 ? 7  
HELX_P HELX_P57 AG3 LYS B 729 ? GLY B 751 ? LYS B 721 GLY B 743 1 ? 23 
HELX_P HELX_P58 AG4 PHE B 752 ? LEU B 758 ? PHE B 744 LEU B 750 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 143 SG  ? ? ? 1_555 A CYS 427 SG  ? ? A CYS 135 A CYS 419 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf2  disulf ? ? B CYS 143 SG  ? ? ? 1_555 B CYS 427 SG  ? ? B CYS 135 B CYS 419 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
metalc1  metalc ? ? A ASP 573 OD2 ? ? ? 1_555 C MN  .   MN  ? ? A ASP 565 A MN  900 1_555 ? ? ? ? ? ? ? 2.749 ? ? 
metalc2  metalc ? ? C MN  .   MN  ? ? ? 1_555 D UDP .   O3A ? ? A MN  900 A UDP 901 1_555 ? ? ? ? ? ? ? 2.185 ? ? 
metalc3  metalc ? ? C MN  .   MN  ? ? ? 1_555 D UDP .   PB  ? ? A MN  900 A UDP 901 1_555 ? ? ? ? ? ? ? 2.485 ? ? 
metalc4  metalc ? ? C MN  .   MN  ? ? ? 1_555 D UDP .   O1B ? ? A MN  900 A UDP 901 1_555 ? ? ? ? ? ? ? 2.173 ? ? 
metalc5  metalc ? ? C MN  .   MN  ? ? ? 1_555 D UDP .   O2B ? ? A MN  900 A UDP 901 1_555 ? ? ? ? ? ? ? 2.684 ? ? 
metalc6  metalc ? ? B ASP 573 OD2 ? ? ? 1_555 E MN  .   MN  ? ? B ASP 565 B MN  801 1_555 ? ? ? ? ? ? ? 2.749 ? ? 
metalc7  metalc ? ? E MN  .   MN  ? ? ? 1_555 F UDP .   O3A ? ? B MN  801 B UDP 802 1_555 ? ? ? ? ? ? ? 2.186 ? ? 
metalc8  metalc ? ? E MN  .   MN  ? ? ? 1_555 F UDP .   PB  ? ? B MN  801 B UDP 802 1_555 ? ? ? ? ? ? ? 2.486 ? ? 
metalc9  metalc ? ? E MN  .   MN  ? ? ? 1_555 F UDP .   O1B ? ? B MN  801 B UDP 802 1_555 ? ? ? ? ? ? ? 2.172 ? ? 
metalc10 metalc ? ? E MN  .   MN  ? ? ? 1_555 F UDP .   O2B ? ? B MN  801 B UDP 802 1_555 ? ? ? ? ? ? ? 2.685 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD2 ? A ASP 573 ? A ASP 565 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O3A ? D UDP . ? A UDP 901 ? 1_555 105.0 ? 
2  OD2 ? A ASP 573 ? A ASP 565 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 PB  ? D UDP . ? A UDP 901 ? 1_555 144.0 ? 
3  O3A ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 PB  ? D UDP . ? A UDP 901 ? 1_555 39.0  ? 
4  OD2 ? A ASP 573 ? A ASP 565 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O1B ? D UDP . ? A UDP 901 ? 1_555 151.7 ? 
5  O3A ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O1B ? D UDP . ? A UDP 901 ? 1_555 68.0  ? 
6  PB  ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O1B ? D UDP . ? A UDP 901 ? 1_555 37.6  ? 
7  OD2 ? A ASP 573 ? A ASP 565 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O2B ? D UDP . ? A UDP 901 ? 1_555 140.8 ? 
8  O3A ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O2B ? D UDP . ? A UDP 901 ? 1_555 58.9  ? 
9  PB  ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O2B ? D UDP . ? A UDP 901 ? 1_555 34.1  ? 
10 O1B ? D UDP .   ? A UDP 901 ? 1_555 MN ? C MN . ? A MN 900 ? 1_555 O2B ? D UDP . ? A UDP 901 ? 1_555 60.8  ? 
11 OD2 ? B ASP 573 ? B ASP 565 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O3A ? F UDP . ? B UDP 802 ? 1_555 105.0 ? 
12 OD2 ? B ASP 573 ? B ASP 565 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 PB  ? F UDP . ? B UDP 802 ? 1_555 143.9 ? 
13 O3A ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 PB  ? F UDP . ? B UDP 802 ? 1_555 39.0  ? 
14 OD2 ? B ASP 573 ? B ASP 565 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O1B ? F UDP . ? B UDP 802 ? 1_555 151.7 ? 
15 O3A ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O1B ? F UDP . ? B UDP 802 ? 1_555 68.0  ? 
16 PB  ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O1B ? F UDP . ? B UDP 802 ? 1_555 37.6  ? 
17 OD2 ? B ASP 573 ? B ASP 565 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O2B ? F UDP . ? B UDP 802 ? 1_555 140.7 ? 
18 O3A ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O2B ? F UDP . ? B UDP 802 ? 1_555 58.9  ? 
19 PB  ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O2B ? F UDP . ? B UDP 802 ? 1_555 34.0  ? 
20 O1B ? F UDP .   ? B UDP 802 ? 1_555 MN ? E MN . ? B MN 801 ? 1_555 O2B ? F UDP . ? B UDP 802 ? 1_555 60.8  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 143 ? CYS A 427 ? CYS A 135 ? 1_555 CYS A 419 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 143 ? CYS B 427 ? CYS B 135 ? 1_555 CYS B 419 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 3 ? 
AA3 ? 9 ? 
AA4 ? 4 ? 
AA5 ? 7 ? 
AA6 ? 3 ? 
AA7 ? 9 ? 
AA8 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? anti-parallel 
AA3 6 7 ? anti-parallel 
AA3 7 8 ? parallel      
AA3 8 9 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? parallel      
AA5 3 4 ? parallel      
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? parallel      
AA6 1 2 ? anti-parallel 
AA6 2 3 ? parallel      
AA7 1 2 ? anti-parallel 
AA7 2 3 ? parallel      
AA7 3 4 ? parallel      
AA7 4 5 ? parallel      
AA7 5 6 ? anti-parallel 
AA7 6 7 ? anti-parallel 
AA7 7 8 ? parallel      
AA7 8 9 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? parallel      
AA8 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 202 ? ASN A 208 ? VAL A 194 ASN A 200 
AA1 2 LEU A 176 ? ALA A 182 ? LEU A 168 ALA A 174 
AA1 3 ILE A 146 ? CYS A 152 ? ILE A 138 CYS A 144 
AA1 4 ARG A 245 ? LEU A 249 ? ARG A 237 LEU A 241 
AA1 5 TYR A 303 ? LEU A 311 ? TYR A 295 LEU A 303 
AA1 6 LEU A 275 ? GLU A 279 ? LEU A 267 GLU A 271 
AA1 7 VAL A 357 ? GLN A 359 ? VAL A 349 GLN A 351 
AA2 1 ILE A 253 ? PHE A 255 ? ILE A 245 PHE A 247 
AA2 2 VAL A 386 ? HIS A 388 ? VAL A 378 HIS A 380 
AA2 3 VAL A 366 ? GLN A 367 ? VAL A 358 GLN A 359 
AA3 1 THR A 464 ? HIS A 465 ? THR A 456 HIS A 457 
AA3 2 VAL A 537 ? VAL A 542 ? VAL A 529 VAL A 534 
AA3 3 ILE A 507 ? LEU A 511 ? ILE A 499 LEU A 503 
AA3 4 VAL A 482 ? LEU A 488 ? VAL A 474 LEU A 480 
AA3 5 TYR A 566 ? LEU A 569 ? TYR A 558 LEU A 561 
AA3 6 TYR A 668 ? ARG A 672 ? TYR A 660 ARG A 664 
AA3 7 LYS A 598 ? VAL A 602 ? LYS A 590 VAL A 594 
AA3 8 GLU A 702 ? VAL A 705 ? GLU A 694 VAL A 697 
AA3 9 TYR A 657 ? VAL A 659 ? TYR A 649 VAL A 651 
AA4 1 PHE A 574 ? PRO A 576 ? PHE A 566 PRO A 568 
AA4 2 MET A 711 ? HIS A 713 ? MET A 703 HIS A 705 
AA4 3 ALA A 604 ? GLU A 606 ? ALA A 596 GLU A 598 
AA4 4 PHE A 631 ? THR A 632 ? PHE A 623 THR A 624 
AA5 1 VAL B 202 ? ASN B 208 ? VAL B 194 ASN B 200 
AA5 2 LEU B 176 ? ALA B 182 ? LEU B 168 ALA B 174 
AA5 3 ILE B 146 ? CYS B 152 ? ILE B 138 CYS B 144 
AA5 4 ARG B 245 ? LEU B 249 ? ARG B 237 LEU B 241 
AA5 5 TYR B 303 ? LEU B 311 ? TYR B 295 LEU B 303 
AA5 6 LEU B 275 ? GLU B 279 ? LEU B 267 GLU B 271 
AA5 7 VAL B 357 ? GLN B 359 ? VAL B 349 GLN B 351 
AA6 1 ILE B 253 ? PHE B 255 ? ILE B 245 PHE B 247 
AA6 2 VAL B 386 ? HIS B 388 ? VAL B 378 HIS B 380 
AA6 3 VAL B 366 ? GLN B 367 ? VAL B 358 GLN B 359 
AA7 1 THR B 464 ? HIS B 465 ? THR B 456 HIS B 457 
AA7 2 VAL B 537 ? VAL B 542 ? VAL B 529 VAL B 534 
AA7 3 ILE B 507 ? LEU B 511 ? ILE B 499 LEU B 503 
AA7 4 VAL B 482 ? LEU B 488 ? VAL B 474 LEU B 480 
AA7 5 TYR B 566 ? LEU B 569 ? TYR B 558 LEU B 561 
AA7 6 TYR B 668 ? ARG B 672 ? TYR B 660 ARG B 664 
AA7 7 LYS B 598 ? VAL B 602 ? LYS B 590 VAL B 594 
AA7 8 GLU B 702 ? VAL B 705 ? GLU B 694 VAL B 697 
AA7 9 TYR B 657 ? VAL B 659 ? TYR B 649 VAL B 651 
AA8 1 PHE B 574 ? PRO B 576 ? PHE B 566 PRO B 568 
AA8 2 MET B 711 ? HIS B 713 ? MET B 703 HIS B 705 
AA8 3 ALA B 604 ? GLU B 606 ? ALA B 596 GLU B 598 
AA8 4 PHE B 631 ? THR B 632 ? PHE B 623 THR B 624 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ASP A 205 ? O ASP A 197 N LEU A 180 ? N LEU A 172 
AA1 2 3 O HIS A 177 ? O HIS A 169 N ILE A 146 ? N ILE A 138 
AA1 3 4 N ALA A 149 ? N ALA A 141 O LEU A 249 ? O LEU A 241 
AA1 4 5 N VAL A 246 ? N VAL A 238 O LEU A 310 ? O LEU A 302 
AA1 5 6 O ASN A 304 ? O ASN A 296 N VAL A 278 ? N VAL A 270 
AA1 6 7 N LEU A 275 ? N LEU A 267 O TYR A 358 ? O TYR A 350 
AA2 1 2 N THR A 254 ? N THR A 246 O ILE A 387 ? O ILE A 379 
AA2 2 3 O HIS A 388 ? O HIS A 380 N VAL A 366 ? N VAL A 358 
AA3 1 2 N HIS A 465 ? N HIS A 457 O ILE A 541 ? O ILE A 533 
AA3 2 3 O GLY A 538 ? O GLY A 530 N ILE A 507 ? N ILE A 499 
AA3 3 4 O SER A 508 ? O SER A 500 N LEU A 484 ? N LEU A 476 
AA3 4 5 N VAL A 485 ? N VAL A 477 O PHE A 568 ? O PHE A 560 
AA3 5 6 N MET A 567 ? N MET A 559 O VAL A 671 ? O VAL A 663 
AA3 6 7 O TYR A 668 ? O TYR A 660 N VAL A 602 ? N VAL A 594 
AA3 7 8 N ILE A 601 ? N ILE A 593 O ILE A 704 ? O ILE A 696 
AA3 8 9 O VAL A 705 ? O VAL A 697 N TYR A 657 ? N TYR A 649 
AA4 1 2 N LEU A 575 ? N LEU A 567 O ILE A 712 ? O ILE A 704 
AA4 2 3 O HIS A 713 ? O HIS A 705 N PHE A 605 ? N PHE A 597 
AA4 3 4 N GLU A 606 ? N GLU A 598 O PHE A 631 ? O PHE A 623 
AA5 1 2 O ASP B 205 ? O ASP B 197 N LEU B 180 ? N LEU B 172 
AA5 2 3 O HIS B 177 ? O HIS B 169 N ILE B 146 ? N ILE B 138 
AA5 3 4 N ALA B 149 ? N ALA B 141 O LEU B 249 ? O LEU B 241 
AA5 4 5 N VAL B 246 ? N VAL B 238 O LEU B 310 ? O LEU B 302 
AA5 5 6 O ASN B 304 ? O ASN B 296 N VAL B 278 ? N VAL B 270 
AA5 6 7 N LEU B 275 ? N LEU B 267 O TYR B 358 ? O TYR B 350 
AA6 1 2 N THR B 254 ? N THR B 246 O ILE B 387 ? O ILE B 379 
AA6 2 3 O HIS B 388 ? O HIS B 380 N VAL B 366 ? N VAL B 358 
AA7 1 2 N HIS B 465 ? N HIS B 457 O ILE B 541 ? O ILE B 533 
AA7 2 3 O GLY B 538 ? O GLY B 530 N ILE B 507 ? N ILE B 499 
AA7 3 4 O SER B 508 ? O SER B 500 N LEU B 484 ? N LEU B 476 
AA7 4 5 N VAL B 485 ? N VAL B 477 O PHE B 568 ? O PHE B 560 
AA7 5 6 N MET B 567 ? N MET B 559 O VAL B 671 ? O VAL B 663 
AA7 6 7 O TYR B 668 ? O TYR B 660 N VAL B 602 ? N VAL B 594 
AA7 7 8 N ILE B 601 ? N ILE B 593 O ILE B 704 ? O ILE B 696 
AA7 8 9 O VAL B 705 ? O VAL B 697 N TYR B 657 ? N TYR B 649 
AA8 1 2 N LEU B 575 ? N LEU B 567 O ILE B 712 ? O ILE B 704 
AA8 2 3 O HIS B 713 ? O HIS B 705 N PHE B 605 ? N PHE B 597 
AA8 3 4 N GLU B 606 ? N GLU B 598 O PHE B 631 ? O PHE B 623 
# 
_pdbx_entry_details.entry_id                   9E1T 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OH A TYR 602 ? ? OH B TYR 602 ? ? 2.11 
2 1 O  B PHE 677 ? ? OH B TYR 723 ? ? 2.18 
3 1 O  A PHE 677 ? ? OH A TYR 723 ? ? 2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 333 ? ? 61.91   -144.68 
2  1 PHE A 355 ? ? -67.75  2.06    
3  1 LEU A 360 ? ? -92.10  52.69   
4  1 CYS A 443 ? ? -97.08  32.30   
5  1 ASP A 483 ? ? -66.24  4.85    
6  1 VAL A 629 ? ? -122.56 -61.32  
7  1 GLU A 658 ? ? -154.94 77.30   
8  1 ARG A 718 ? ? -79.62  49.38   
9  1 LYS A 721 ? ? 62.54   -125.22 
10 1 ALA B 333 ? ? 61.93   -144.69 
11 1 PHE B 355 ? ? -67.76  2.08    
12 1 LEU B 360 ? ? -92.18  52.81   
13 1 CYS B 443 ? ? -97.07  32.26   
14 1 ASP B 483 ? ? -66.28  4.92    
15 1 VAL B 629 ? ? -122.53 -61.31  
16 1 GLU B 658 ? ? -154.94 77.28   
17 1 ARG B 718 ? ? -79.66  49.38   
18 1 LYS B 721 ? ? 62.62   -125.30 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9E1T 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9E1T 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.0 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               347589 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            6.6 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 LARGE1 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9E1T 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            50 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R2/2' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9E1T 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9E1T 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9E1T 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -7  ? A MET 1   
2   1 Y 1 A SER -6  ? A SER 2   
3   1 Y 1 A ALA -5  ? A ALA 3   
4   1 Y 1 A LEU -4  ? A LEU 4   
5   1 Y 1 A LEU -3  ? A LEU 5   
6   1 Y 1 A ILE -2  ? A ILE 6   
7   1 Y 1 A LEU -1  ? A LEU 7   
8   1 Y 1 A ALA 0   ? A ALA 8   
9   1 Y 1 A LEU 1   ? A LEU 9   
10  1 Y 1 A VAL 2   ? A VAL 10  
11  1 Y 1 A GLY 3   ? A GLY 11  
12  1 Y 1 A ALA 4   ? A ALA 12  
13  1 Y 1 A ALA 5   ? A ALA 13  
14  1 Y 1 A VAL 6   ? A VAL 14  
15  1 Y 1 A ALA 7   ? A ALA 15  
16  1 Y 1 A ASP 8   ? A ASP 16  
17  1 Y 1 A TYR 9   ? A TYR 17  
18  1 Y 1 A LYS 10  ? A LYS 18  
19  1 Y 1 A ASP 11  ? A ASP 19  
20  1 Y 1 A HIS 12  ? A HIS 20  
21  1 Y 1 A ASP 13  ? A ASP 21  
22  1 Y 1 A GLY 14  ? A GLY 22  
23  1 Y 1 A ASP 15  ? A ASP 23  
24  1 Y 1 A TYR 16  ? A TYR 24  
25  1 Y 1 A LYS 17  ? A LYS 25  
26  1 Y 1 A ASP 18  ? A ASP 26  
27  1 Y 1 A HIS 19  ? A HIS 27  
28  1 Y 1 A ASP 20  ? A ASP 28  
29  1 Y 1 A ILE 21  ? A ILE 29  
30  1 Y 1 A ASP 22  ? A ASP 30  
31  1 Y 1 A TYR 23  ? A TYR 31  
32  1 Y 1 A LYS 24  ? A LYS 32  
33  1 Y 1 A ASP 25  ? A ASP 33  
34  1 Y 1 A ASP 26  ? A ASP 34  
35  1 Y 1 A ASP 27  ? A ASP 35  
36  1 Y 1 A ASP 28  ? A ASP 36  
37  1 Y 1 A LYS 29  ? A LYS 37  
38  1 Y 1 A LEU 30  ? A LEU 38  
39  1 Y 1 A ALA 31  ? A ALA 39  
40  1 Y 1 A ALA 32  ? A ALA 40  
41  1 Y 1 A ALA 33  ? A ALA 41  
42  1 Y 1 A PHE 34  ? A PHE 42  
43  1 Y 1 A GLU 35  ? A GLU 43  
44  1 Y 1 A ASP 36  ? A ASP 44  
45  1 Y 1 A GLY 37  ? A GLY 45  
46  1 Y 1 A LYS 38  ? A LYS 46  
47  1 Y 1 A PRO 39  ? A PRO 47  
48  1 Y 1 A VAL 40  ? A VAL 48  
49  1 Y 1 A SER 41  ? A SER 49  
50  1 Y 1 A LEU 42  ? A LEU 50  
51  1 Y 1 A SER 43  ? A SER 51  
52  1 Y 1 A PRO 44  ? A PRO 52  
53  1 Y 1 A LEU 45  ? A LEU 53  
54  1 Y 1 A GLU 46  ? A GLU 54  
55  1 Y 1 A SER 47  ? A SER 55  
56  1 Y 1 A GLN 48  ? A GLN 56  
57  1 Y 1 A ALA 49  ? A ALA 57  
58  1 Y 1 A HIS 50  ? A HIS 58  
59  1 Y 1 A SER 51  ? A SER 59  
60  1 Y 1 A PRO 52  ? A PRO 60  
61  1 Y 1 A ARG 53  ? A ARG 61  
62  1 Y 1 A TYR 54  ? A TYR 62  
63  1 Y 1 A THR 55  ? A THR 63  
64  1 Y 1 A ALA 56  ? A ALA 64  
65  1 Y 1 A SER 57  ? A SER 65  
66  1 Y 1 A SER 58  ? A SER 66  
67  1 Y 1 A GLN 59  ? A GLN 67  
68  1 Y 1 A ARG 60  ? A ARG 68  
69  1 Y 1 A GLU 61  ? A GLU 69  
70  1 Y 1 A ARG 62  ? A ARG 70  
71  1 Y 1 A GLU 63  ? A GLU 71  
72  1 Y 1 A SER 64  ? A SER 72  
73  1 Y 1 A LEU 65  ? A LEU 73  
74  1 Y 1 A GLU 66  ? A GLU 74  
75  1 Y 1 A VAL 67  ? A VAL 75  
76  1 Y 1 A ARG 68  ? A ARG 76  
77  1 Y 1 A MET 69  ? A MET 77  
78  1 Y 1 A ARG 70  ? A ARG 78  
79  1 Y 1 A GLU 71  ? A GLU 79  
80  1 Y 1 A VAL 72  ? A VAL 80  
81  1 Y 1 A GLU 73  ? A GLU 81  
82  1 Y 1 A GLU 74  ? A GLU 82  
83  1 Y 1 A GLU 75  ? A GLU 83  
84  1 Y 1 A ASN 76  ? A ASN 84  
85  1 Y 1 A ARG 77  ? A ARG 85  
86  1 Y 1 A ALA 78  ? A ALA 86  
87  1 Y 1 A LEU 79  ? A LEU 87  
88  1 Y 1 A ARG 80  ? A ARG 88  
89  1 Y 1 A ARG 81  ? A ARG 89  
90  1 Y 1 A GLN 82  ? A GLN 90  
91  1 Y 1 A LEU 83  ? A LEU 91  
92  1 Y 1 A SER 84  ? A SER 92  
93  1 Y 1 A LEU 85  ? A LEU 93  
94  1 Y 1 A ALA 86  ? A ALA 94  
95  1 Y 1 A GLN 87  ? A GLN 95  
96  1 Y 1 A GLY 88  ? A GLY 96  
97  1 Y 1 A ARG 89  ? A ARG 97  
98  1 Y 1 A ALA 90  ? A ALA 98  
99  1 Y 1 A PRO 91  ? A PRO 99  
100 1 Y 1 A SER 92  ? A SER 100 
101 1 Y 1 A HIS 93  ? A HIS 101 
102 1 Y 1 A ARG 94  ? A ARG 102 
103 1 Y 1 A ARG 95  ? A ARG 103 
104 1 Y 1 A GLY 96  ? A GLY 104 
105 1 Y 1 A ASN 97  ? A ASN 105 
106 1 Y 1 A HIS 98  ? A HIS 106 
107 1 Y 1 A SER 99  ? A SER 107 
108 1 Y 1 A LYS 100 ? A LYS 108 
109 1 Y 1 A THR 101 ? A THR 109 
110 1 Y 1 A TYR 102 ? A TYR 110 
111 1 Y 1 A SER 103 ? A SER 111 
112 1 Y 1 A MET 104 ? A MET 112 
113 1 Y 1 A GLU 105 ? A GLU 113 
114 1 Y 1 A GLU 106 ? A GLU 114 
115 1 Y 1 A GLY 107 ? A GLY 115 
116 1 Y 1 A THR 108 ? A THR 116 
117 1 Y 1 A GLY 109 ? A GLY 117 
118 1 Y 1 A ASP 110 ? A ASP 118 
119 1 Y 1 A SER 111 ? A SER 119 
120 1 Y 1 A GLU 112 ? A GLU 120 
121 1 Y 1 A ASN 113 ? A ASN 121 
122 1 Y 1 A LEU 114 ? A LEU 122 
123 1 Y 1 A ARG 115 ? A ARG 123 
124 1 Y 1 A ALA 116 ? A ALA 124 
125 1 Y 1 A GLY 117 ? A GLY 125 
126 1 Y 1 A ILE 118 ? A ILE 126 
127 1 Y 1 A VAL 119 ? A VAL 127 
128 1 Y 1 A ALA 120 ? A ALA 128 
129 1 Y 1 A GLY 121 ? A GLY 129 
130 1 Y 1 A ASN 122 ? A ASN 130 
131 1 Y 1 A SER 123 ? A SER 131 
132 1 Y 1 A SER 124 ? A SER 132 
133 1 Y 1 A GLU 125 ? A GLU 133 
134 1 Y 1 A CYS 126 ? A CYS 134 
135 1 Y 1 A GLY 127 ? A GLY 135 
136 1 Y 1 A GLN 128 ? A GLN 136 
137 1 Y 1 A GLN 129 ? A GLN 137 
138 1 Y 1 A PRO 130 ? A PRO 138 
139 1 Y 1 A VAL 131 ? A VAL 139 
140 1 Y 1 A VAL 132 ? A VAL 140 
141 1 Y 1 A GLU 133 ? A GLU 141 
142 1 Y 1 A ASN 280 ? A ASN 288 
143 1 Y 1 A LEU 281 ? A LEU 289 
144 1 Y 1 A TRP 282 ? A TRP 290 
145 1 Y 1 A LYS 283 ? A LYS 291 
146 1 Y 1 A ASN 284 ? A ASN 292 
147 1 Y 1 A HIS 285 ? A HIS 293 
148 1 Y 1 A ARG 286 ? A ARG 294 
149 1 Y 1 A LYS 385 ? A LYS 393 
150 1 Y 1 A LYS 386 ? A LYS 394 
151 1 Y 1 A LEU 387 ? A LEU 395 
152 1 Y 1 A ARG 388 ? A ARG 396 
153 1 Y 1 A VAL 389 ? A VAL 397 
154 1 Y 1 A LYS 390 ? A LYS 398 
155 1 Y 1 A ASN 391 ? A ASN 399 
156 1 Y 1 A LYS 392 ? A LYS 400 
157 1 Y 1 A HIS 393 ? A HIS 401 
158 1 Y 1 A VAL 394 ? A VAL 402 
159 1 Y 1 A GLU 753 ? A GLU 761 
160 1 Y 1 A ASN 754 ? A ASN 762 
161 1 Y 1 A ASN 755 ? A ASN 763 
162 1 Y 1 A SER 756 ? A SER 764 
163 1 Y 1 A HIS 757 ? A HIS 765 
164 1 Y 1 A HIS 758 ? A HIS 766 
165 1 Y 1 A HIS 759 ? A HIS 767 
166 1 Y 1 A HIS 760 ? A HIS 768 
167 1 Y 1 A HIS 761 ? A HIS 769 
168 1 Y 1 A HIS 762 ? A HIS 770 
169 1 Y 1 B MET -7  ? B MET 1   
170 1 Y 1 B SER -6  ? B SER 2   
171 1 Y 1 B ALA -5  ? B ALA 3   
172 1 Y 1 B LEU -4  ? B LEU 4   
173 1 Y 1 B LEU -3  ? B LEU 5   
174 1 Y 1 B ILE -2  ? B ILE 6   
175 1 Y 1 B LEU -1  ? B LEU 7   
176 1 Y 1 B ALA 0   ? B ALA 8   
177 1 Y 1 B LEU 1   ? B LEU 9   
178 1 Y 1 B VAL 2   ? B VAL 10  
179 1 Y 1 B GLY 3   ? B GLY 11  
180 1 Y 1 B ALA 4   ? B ALA 12  
181 1 Y 1 B ALA 5   ? B ALA 13  
182 1 Y 1 B VAL 6   ? B VAL 14  
183 1 Y 1 B ALA 7   ? B ALA 15  
184 1 Y 1 B ASP 8   ? B ASP 16  
185 1 Y 1 B TYR 9   ? B TYR 17  
186 1 Y 1 B LYS 10  ? B LYS 18  
187 1 Y 1 B ASP 11  ? B ASP 19  
188 1 Y 1 B HIS 12  ? B HIS 20  
189 1 Y 1 B ASP 13  ? B ASP 21  
190 1 Y 1 B GLY 14  ? B GLY 22  
191 1 Y 1 B ASP 15  ? B ASP 23  
192 1 Y 1 B TYR 16  ? B TYR 24  
193 1 Y 1 B LYS 17  ? B LYS 25  
194 1 Y 1 B ASP 18  ? B ASP 26  
195 1 Y 1 B HIS 19  ? B HIS 27  
196 1 Y 1 B ASP 20  ? B ASP 28  
197 1 Y 1 B ILE 21  ? B ILE 29  
198 1 Y 1 B ASP 22  ? B ASP 30  
199 1 Y 1 B TYR 23  ? B TYR 31  
200 1 Y 1 B LYS 24  ? B LYS 32  
201 1 Y 1 B ASP 25  ? B ASP 33  
202 1 Y 1 B ASP 26  ? B ASP 34  
203 1 Y 1 B ASP 27  ? B ASP 35  
204 1 Y 1 B ASP 28  ? B ASP 36  
205 1 Y 1 B LYS 29  ? B LYS 37  
206 1 Y 1 B LEU 30  ? B LEU 38  
207 1 Y 1 B ALA 31  ? B ALA 39  
208 1 Y 1 B ALA 32  ? B ALA 40  
209 1 Y 1 B ALA 33  ? B ALA 41  
210 1 Y 1 B PHE 34  ? B PHE 42  
211 1 Y 1 B GLU 35  ? B GLU 43  
212 1 Y 1 B ASP 36  ? B ASP 44  
213 1 Y 1 B GLY 37  ? B GLY 45  
214 1 Y 1 B LYS 38  ? B LYS 46  
215 1 Y 1 B PRO 39  ? B PRO 47  
216 1 Y 1 B VAL 40  ? B VAL 48  
217 1 Y 1 B SER 41  ? B SER 49  
218 1 Y 1 B LEU 42  ? B LEU 50  
219 1 Y 1 B SER 43  ? B SER 51  
220 1 Y 1 B PRO 44  ? B PRO 52  
221 1 Y 1 B LEU 45  ? B LEU 53  
222 1 Y 1 B GLU 46  ? B GLU 54  
223 1 Y 1 B SER 47  ? B SER 55  
224 1 Y 1 B GLN 48  ? B GLN 56  
225 1 Y 1 B ALA 49  ? B ALA 57  
226 1 Y 1 B HIS 50  ? B HIS 58  
227 1 Y 1 B SER 51  ? B SER 59  
228 1 Y 1 B PRO 52  ? B PRO 60  
229 1 Y 1 B ARG 53  ? B ARG 61  
230 1 Y 1 B TYR 54  ? B TYR 62  
231 1 Y 1 B THR 55  ? B THR 63  
232 1 Y 1 B ALA 56  ? B ALA 64  
233 1 Y 1 B SER 57  ? B SER 65  
234 1 Y 1 B SER 58  ? B SER 66  
235 1 Y 1 B GLN 59  ? B GLN 67  
236 1 Y 1 B ARG 60  ? B ARG 68  
237 1 Y 1 B GLU 61  ? B GLU 69  
238 1 Y 1 B ARG 62  ? B ARG 70  
239 1 Y 1 B GLU 63  ? B GLU 71  
240 1 Y 1 B SER 64  ? B SER 72  
241 1 Y 1 B LEU 65  ? B LEU 73  
242 1 Y 1 B GLU 66  ? B GLU 74  
243 1 Y 1 B VAL 67  ? B VAL 75  
244 1 Y 1 B ARG 68  ? B ARG 76  
245 1 Y 1 B MET 69  ? B MET 77  
246 1 Y 1 B ARG 70  ? B ARG 78  
247 1 Y 1 B GLU 71  ? B GLU 79  
248 1 Y 1 B VAL 72  ? B VAL 80  
249 1 Y 1 B GLU 73  ? B GLU 81  
250 1 Y 1 B GLU 74  ? B GLU 82  
251 1 Y 1 B GLU 75  ? B GLU 83  
252 1 Y 1 B ASN 76  ? B ASN 84  
253 1 Y 1 B ARG 77  ? B ARG 85  
254 1 Y 1 B ALA 78  ? B ALA 86  
255 1 Y 1 B LEU 79  ? B LEU 87  
256 1 Y 1 B ARG 80  ? B ARG 88  
257 1 Y 1 B ARG 81  ? B ARG 89  
258 1 Y 1 B GLN 82  ? B GLN 90  
259 1 Y 1 B LEU 83  ? B LEU 91  
260 1 Y 1 B SER 84  ? B SER 92  
261 1 Y 1 B LEU 85  ? B LEU 93  
262 1 Y 1 B ALA 86  ? B ALA 94  
263 1 Y 1 B GLN 87  ? B GLN 95  
264 1 Y 1 B GLY 88  ? B GLY 96  
265 1 Y 1 B ARG 89  ? B ARG 97  
266 1 Y 1 B ALA 90  ? B ALA 98  
267 1 Y 1 B PRO 91  ? B PRO 99  
268 1 Y 1 B SER 92  ? B SER 100 
269 1 Y 1 B HIS 93  ? B HIS 101 
270 1 Y 1 B ARG 94  ? B ARG 102 
271 1 Y 1 B ARG 95  ? B ARG 103 
272 1 Y 1 B GLY 96  ? B GLY 104 
273 1 Y 1 B ASN 97  ? B ASN 105 
274 1 Y 1 B HIS 98  ? B HIS 106 
275 1 Y 1 B SER 99  ? B SER 107 
276 1 Y 1 B LYS 100 ? B LYS 108 
277 1 Y 1 B THR 101 ? B THR 109 
278 1 Y 1 B TYR 102 ? B TYR 110 
279 1 Y 1 B SER 103 ? B SER 111 
280 1 Y 1 B MET 104 ? B MET 112 
281 1 Y 1 B GLU 105 ? B GLU 113 
282 1 Y 1 B GLU 106 ? B GLU 114 
283 1 Y 1 B GLY 107 ? B GLY 115 
284 1 Y 1 B THR 108 ? B THR 116 
285 1 Y 1 B GLY 109 ? B GLY 117 
286 1 Y 1 B ASP 110 ? B ASP 118 
287 1 Y 1 B SER 111 ? B SER 119 
288 1 Y 1 B GLU 112 ? B GLU 120 
289 1 Y 1 B ASN 113 ? B ASN 121 
290 1 Y 1 B LEU 114 ? B LEU 122 
291 1 Y 1 B ARG 115 ? B ARG 123 
292 1 Y 1 B ALA 116 ? B ALA 124 
293 1 Y 1 B GLY 117 ? B GLY 125 
294 1 Y 1 B ILE 118 ? B ILE 126 
295 1 Y 1 B VAL 119 ? B VAL 127 
296 1 Y 1 B ALA 120 ? B ALA 128 
297 1 Y 1 B GLY 121 ? B GLY 129 
298 1 Y 1 B ASN 122 ? B ASN 130 
299 1 Y 1 B SER 123 ? B SER 131 
300 1 Y 1 B SER 124 ? B SER 132 
301 1 Y 1 B GLU 125 ? B GLU 133 
302 1 Y 1 B CYS 126 ? B CYS 134 
303 1 Y 1 B GLY 127 ? B GLY 135 
304 1 Y 1 B GLN 128 ? B GLN 136 
305 1 Y 1 B GLN 129 ? B GLN 137 
306 1 Y 1 B PRO 130 ? B PRO 138 
307 1 Y 1 B VAL 131 ? B VAL 139 
308 1 Y 1 B VAL 132 ? B VAL 140 
309 1 Y 1 B GLU 133 ? B GLU 141 
310 1 Y 1 B ASN 280 ? B ASN 288 
311 1 Y 1 B LEU 281 ? B LEU 289 
312 1 Y 1 B TRP 282 ? B TRP 290 
313 1 Y 1 B LYS 283 ? B LYS 291 
314 1 Y 1 B ASN 284 ? B ASN 292 
315 1 Y 1 B HIS 285 ? B HIS 293 
316 1 Y 1 B ARG 286 ? B ARG 294 
317 1 Y 1 B LYS 385 ? B LYS 393 
318 1 Y 1 B LYS 386 ? B LYS 394 
319 1 Y 1 B LEU 387 ? B LEU 395 
320 1 Y 1 B ARG 388 ? B ARG 396 
321 1 Y 1 B VAL 389 ? B VAL 397 
322 1 Y 1 B LYS 390 ? B LYS 398 
323 1 Y 1 B ASN 391 ? B ASN 399 
324 1 Y 1 B LYS 392 ? B LYS 400 
325 1 Y 1 B HIS 393 ? B HIS 401 
326 1 Y 1 B VAL 394 ? B VAL 402 
327 1 Y 1 B GLU 753 ? B GLU 761 
328 1 Y 1 B ASN 754 ? B ASN 762 
329 1 Y 1 B ASN 755 ? B ASN 763 
330 1 Y 1 B SER 756 ? B SER 764 
331 1 Y 1 B HIS 757 ? B HIS 765 
332 1 Y 1 B HIS 758 ? B HIS 766 
333 1 Y 1 B HIS 759 ? B HIS 767 
334 1 Y 1 B HIS 760 ? B HIS 768 
335 1 Y 1 B HIS 761 ? B HIS 769 
336 1 Y 1 B HIS 762 ? B HIS 770 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CYS N      N  N N 74  
CYS CA     C  N R 75  
CYS C      C  N N 76  
CYS O      O  N N 77  
CYS CB     C  N N 78  
CYS SG     S  N N 79  
CYS OXT    O  N N 80  
CYS H      H  N N 81  
CYS H2     H  N N 82  
CYS HA     H  N N 83  
CYS HB2    H  N N 84  
CYS HB3    H  N N 85  
CYS HG     H  N N 86  
CYS HXT    H  N N 87  
GLN N      N  N N 88  
GLN CA     C  N S 89  
GLN C      C  N N 90  
GLN O      O  N N 91  
GLN CB     C  N N 92  
GLN CG     C  N N 93  
GLN CD     C  N N 94  
GLN OE1    O  N N 95  
GLN NE2    N  N N 96  
GLN OXT    O  N N 97  
GLN H      H  N N 98  
GLN H2     H  N N 99  
GLN HA     H  N N 100 
GLN HB2    H  N N 101 
GLN HB3    H  N N 102 
GLN HG2    H  N N 103 
GLN HG3    H  N N 104 
GLN HE21   H  N N 105 
GLN HE22   H  N N 106 
GLN HXT    H  N N 107 
GLU N      N  N N 108 
GLU CA     C  N S 109 
GLU C      C  N N 110 
GLU O      O  N N 111 
GLU CB     C  N N 112 
GLU CG     C  N N 113 
GLU CD     C  N N 114 
GLU OE1    O  N N 115 
GLU OE2    O  N N 116 
GLU OXT    O  N N 117 
GLU H      H  N N 118 
GLU H2     H  N N 119 
GLU HA     H  N N 120 
GLU HB2    H  N N 121 
GLU HB3    H  N N 122 
GLU HG2    H  N N 123 
GLU HG3    H  N N 124 
GLU HE2    H  N N 125 
GLU HXT    H  N N 126 
GLY N      N  N N 127 
GLY CA     C  N N 128 
GLY C      C  N N 129 
GLY O      O  N N 130 
GLY OXT    O  N N 131 
GLY H      H  N N 132 
GLY H2     H  N N 133 
GLY HA2    H  N N 134 
GLY HA3    H  N N 135 
GLY HXT    H  N N 136 
HIS N      N  N N 137 
HIS CA     C  N S 138 
HIS C      C  N N 139 
HIS O      O  N N 140 
HIS CB     C  N N 141 
HIS CG     C  Y N 142 
HIS ND1    N  Y N 143 
HIS CD2    C  Y N 144 
HIS CE1    C  Y N 145 
HIS NE2    N  Y N 146 
HIS OXT    O  N N 147 
HIS H      H  N N 148 
HIS H2     H  N N 149 
HIS HA     H  N N 150 
HIS HB2    H  N N 151 
HIS HB3    H  N N 152 
HIS HD1    H  N N 153 
HIS HD2    H  N N 154 
HIS HE1    H  N N 155 
HIS HE2    H  N N 156 
HIS HXT    H  N N 157 
ILE N      N  N N 158 
ILE CA     C  N S 159 
ILE C      C  N N 160 
ILE O      O  N N 161 
ILE CB     C  N S 162 
ILE CG1    C  N N 163 
ILE CG2    C  N N 164 
ILE CD1    C  N N 165 
ILE OXT    O  N N 166 
ILE H      H  N N 167 
ILE H2     H  N N 168 
ILE HA     H  N N 169 
ILE HB     H  N N 170 
ILE HG12   H  N N 171 
ILE HG13   H  N N 172 
ILE HG21   H  N N 173 
ILE HG22   H  N N 174 
ILE HG23   H  N N 175 
ILE HD11   H  N N 176 
ILE HD12   H  N N 177 
ILE HD13   H  N N 178 
ILE HXT    H  N N 179 
LEU N      N  N N 180 
LEU CA     C  N S 181 
LEU C      C  N N 182 
LEU O      O  N N 183 
LEU CB     C  N N 184 
LEU CG     C  N N 185 
LEU CD1    C  N N 186 
LEU CD2    C  N N 187 
LEU OXT    O  N N 188 
LEU H      H  N N 189 
LEU H2     H  N N 190 
LEU HA     H  N N 191 
LEU HB2    H  N N 192 
LEU HB3    H  N N 193 
LEU HG     H  N N 194 
LEU HD11   H  N N 195 
LEU HD12   H  N N 196 
LEU HD13   H  N N 197 
LEU HD21   H  N N 198 
LEU HD22   H  N N 199 
LEU HD23   H  N N 200 
LEU HXT    H  N N 201 
LYS N      N  N N 202 
LYS CA     C  N S 203 
LYS C      C  N N 204 
LYS O      O  N N 205 
LYS CB     C  N N 206 
LYS CG     C  N N 207 
LYS CD     C  N N 208 
LYS CE     C  N N 209 
LYS NZ     N  N N 210 
LYS OXT    O  N N 211 
LYS H      H  N N 212 
LYS H2     H  N N 213 
LYS HA     H  N N 214 
LYS HB2    H  N N 215 
LYS HB3    H  N N 216 
LYS HG2    H  N N 217 
LYS HG3    H  N N 218 
LYS HD2    H  N N 219 
LYS HD3    H  N N 220 
LYS HE2    H  N N 221 
LYS HE3    H  N N 222 
LYS HZ1    H  N N 223 
LYS HZ2    H  N N 224 
LYS HZ3    H  N N 225 
LYS HXT    H  N N 226 
MET N      N  N N 227 
MET CA     C  N S 228 
MET C      C  N N 229 
MET O      O  N N 230 
MET CB     C  N N 231 
MET CG     C  N N 232 
MET SD     S  N N 233 
MET CE     C  N N 234 
MET OXT    O  N N 235 
MET H      H  N N 236 
MET H2     H  N N 237 
MET HA     H  N N 238 
MET HB2    H  N N 239 
MET HB3    H  N N 240 
MET HG2    H  N N 241 
MET HG3    H  N N 242 
MET HE1    H  N N 243 
MET HE2    H  N N 244 
MET HE3    H  N N 245 
MET HXT    H  N N 246 
MN  MN     MN N N 247 
PHE N      N  N N 248 
PHE CA     C  N S 249 
PHE C      C  N N 250 
PHE O      O  N N 251 
PHE CB     C  N N 252 
PHE CG     C  Y N 253 
PHE CD1    C  Y N 254 
PHE CD2    C  Y N 255 
PHE CE1    C  Y N 256 
PHE CE2    C  Y N 257 
PHE CZ     C  Y N 258 
PHE OXT    O  N N 259 
PHE H      H  N N 260 
PHE H2     H  N N 261 
PHE HA     H  N N 262 
PHE HB2    H  N N 263 
PHE HB3    H  N N 264 
PHE HD1    H  N N 265 
PHE HD2    H  N N 266 
PHE HE1    H  N N 267 
PHE HE2    H  N N 268 
PHE HZ     H  N N 269 
PHE HXT    H  N N 270 
PRO N      N  N N 271 
PRO CA     C  N S 272 
PRO C      C  N N 273 
PRO O      O  N N 274 
PRO CB     C  N N 275 
PRO CG     C  N N 276 
PRO CD     C  N N 277 
PRO OXT    O  N N 278 
PRO H      H  N N 279 
PRO HA     H  N N 280 
PRO HB2    H  N N 281 
PRO HB3    H  N N 282 
PRO HG2    H  N N 283 
PRO HG3    H  N N 284 
PRO HD2    H  N N 285 
PRO HD3    H  N N 286 
PRO HXT    H  N N 287 
SER N      N  N N 288 
SER CA     C  N S 289 
SER C      C  N N 290 
SER O      O  N N 291 
SER CB     C  N N 292 
SER OG     O  N N 293 
SER OXT    O  N N 294 
SER H      H  N N 295 
SER H2     H  N N 296 
SER HA     H  N N 297 
SER HB2    H  N N 298 
SER HB3    H  N N 299 
SER HG     H  N N 300 
SER HXT    H  N N 301 
THR N      N  N N 302 
THR CA     C  N S 303 
THR C      C  N N 304 
THR O      O  N N 305 
THR CB     C  N R 306 
THR OG1    O  N N 307 
THR CG2    C  N N 308 
THR OXT    O  N N 309 
THR H      H  N N 310 
THR H2     H  N N 311 
THR HA     H  N N 312 
THR HB     H  N N 313 
THR HG1    H  N N 314 
THR HG21   H  N N 315 
THR HG22   H  N N 316 
THR HG23   H  N N 317 
THR HXT    H  N N 318 
TRP N      N  N N 319 
TRP CA     C  N S 320 
TRP C      C  N N 321 
TRP O      O  N N 322 
TRP CB     C  N N 323 
TRP CG     C  Y N 324 
TRP CD1    C  Y N 325 
TRP CD2    C  Y N 326 
TRP NE1    N  Y N 327 
TRP CE2    C  Y N 328 
TRP CE3    C  Y N 329 
TRP CZ2    C  Y N 330 
TRP CZ3    C  Y N 331 
TRP CH2    C  Y N 332 
TRP OXT    O  N N 333 
TRP H      H  N N 334 
TRP H2     H  N N 335 
TRP HA     H  N N 336 
TRP HB2    H  N N 337 
TRP HB3    H  N N 338 
TRP HD1    H  N N 339 
TRP HE1    H  N N 340 
TRP HE3    H  N N 341 
TRP HZ2    H  N N 342 
TRP HZ3    H  N N 343 
TRP HH2    H  N N 344 
TRP HXT    H  N N 345 
TYR N      N  N N 346 
TYR CA     C  N S 347 
TYR C      C  N N 348 
TYR O      O  N N 349 
TYR CB     C  N N 350 
TYR CG     C  Y N 351 
TYR CD1    C  Y N 352 
TYR CD2    C  Y N 353 
TYR CE1    C  Y N 354 
TYR CE2    C  Y N 355 
TYR CZ     C  Y N 356 
TYR OH     O  N N 357 
TYR OXT    O  N N 358 
TYR H      H  N N 359 
TYR H2     H  N N 360 
TYR HA     H  N N 361 
TYR HB2    H  N N 362 
TYR HB3    H  N N 363 
TYR HD1    H  N N 364 
TYR HD2    H  N N 365 
TYR HE1    H  N N 366 
TYR HE2    H  N N 367 
TYR HH     H  N N 368 
TYR HXT    H  N N 369 
UDP N1     N  N N 370 
UDP C2     C  N N 371 
UDP N3     N  N N 372 
UDP C4     C  N N 373 
UDP C5     C  N N 374 
UDP C6     C  N N 375 
UDP O2     O  N N 376 
UDP O4     O  N N 377 
UDP "C1'"  C  N R 378 
UDP "C2'"  C  N R 379 
UDP "O2'"  O  N N 380 
UDP "C3'"  C  N S 381 
UDP "C4'"  C  N R 382 
UDP "O4'"  O  N N 383 
UDP "O3'"  O  N N 384 
UDP "C5'"  C  N N 385 
UDP "O5'"  O  N N 386 
UDP PA     P  N N 387 
UDP O1A    O  N N 388 
UDP O2A    O  N N 389 
UDP O3A    O  N N 390 
UDP PB     P  N N 391 
UDP O1B    O  N N 392 
UDP O2B    O  N N 393 
UDP O3B    O  N N 394 
UDP HN3    H  N N 395 
UDP H5     H  N N 396 
UDP H6     H  N N 397 
UDP "H1'"  H  N N 398 
UDP "H2'"  H  N N 399 
UDP "HO2'" H  N N 400 
UDP "H3'"  H  N N 401 
UDP "H4'"  H  N N 402 
UDP "HO3'" H  N N 403 
UDP "H5'1" H  N N 404 
UDP "H5'2" H  N N 405 
UDP HOA2   H  N N 406 
UDP HOB2   H  N N 407 
UDP HOB3   H  N N 408 
VAL N      N  N N 409 
VAL CA     C  N S 410 
VAL C      C  N N 411 
VAL O      O  N N 412 
VAL CB     C  N N 413 
VAL CG1    C  N N 414 
VAL CG2    C  N N 415 
VAL OXT    O  N N 416 
VAL H      H  N N 417 
VAL H2     H  N N 418 
VAL HA     H  N N 419 
VAL HB     H  N N 420 
VAL HG11   H  N N 421 
VAL HG12   H  N N 422 
VAL HG13   H  N N 423 
VAL HG21   H  N N 424 
VAL HG22   H  N N 425 
VAL HG23   H  N N 426 
VAL HXT    H  N N 427 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
HIS N     CA     sing N N 129 
HIS N     H      sing N N 130 
HIS N     H2     sing N N 131 
HIS CA    C      sing N N 132 
HIS CA    CB     sing N N 133 
HIS CA    HA     sing N N 134 
HIS C     O      doub N N 135 
HIS C     OXT    sing N N 136 
HIS CB    CG     sing N N 137 
HIS CB    HB2    sing N N 138 
HIS CB    HB3    sing N N 139 
HIS CG    ND1    sing Y N 140 
HIS CG    CD2    doub Y N 141 
HIS ND1   CE1    doub Y N 142 
HIS ND1   HD1    sing N N 143 
HIS CD2   NE2    sing Y N 144 
HIS CD2   HD2    sing N N 145 
HIS CE1   NE2    sing Y N 146 
HIS CE1   HE1    sing N N 147 
HIS NE2   HE2    sing N N 148 
HIS OXT   HXT    sing N N 149 
ILE N     CA     sing N N 150 
ILE N     H      sing N N 151 
ILE N     H2     sing N N 152 
ILE CA    C      sing N N 153 
ILE CA    CB     sing N N 154 
ILE CA    HA     sing N N 155 
ILE C     O      doub N N 156 
ILE C     OXT    sing N N 157 
ILE CB    CG1    sing N N 158 
ILE CB    CG2    sing N N 159 
ILE CB    HB     sing N N 160 
ILE CG1   CD1    sing N N 161 
ILE CG1   HG12   sing N N 162 
ILE CG1   HG13   sing N N 163 
ILE CG2   HG21   sing N N 164 
ILE CG2   HG22   sing N N 165 
ILE CG2   HG23   sing N N 166 
ILE CD1   HD11   sing N N 167 
ILE CD1   HD12   sing N N 168 
ILE CD1   HD13   sing N N 169 
ILE OXT   HXT    sing N N 170 
LEU N     CA     sing N N 171 
LEU N     H      sing N N 172 
LEU N     H2     sing N N 173 
LEU CA    C      sing N N 174 
LEU CA    CB     sing N N 175 
LEU CA    HA     sing N N 176 
LEU C     O      doub N N 177 
LEU C     OXT    sing N N 178 
LEU CB    CG     sing N N 179 
LEU CB    HB2    sing N N 180 
LEU CB    HB3    sing N N 181 
LEU CG    CD1    sing N N 182 
LEU CG    CD2    sing N N 183 
LEU CG    HG     sing N N 184 
LEU CD1   HD11   sing N N 185 
LEU CD1   HD12   sing N N 186 
LEU CD1   HD13   sing N N 187 
LEU CD2   HD21   sing N N 188 
LEU CD2   HD22   sing N N 189 
LEU CD2   HD23   sing N N 190 
LEU OXT   HXT    sing N N 191 
LYS N     CA     sing N N 192 
LYS N     H      sing N N 193 
LYS N     H2     sing N N 194 
LYS CA    C      sing N N 195 
LYS CA    CB     sing N N 196 
LYS CA    HA     sing N N 197 
LYS C     O      doub N N 198 
LYS C     OXT    sing N N 199 
LYS CB    CG     sing N N 200 
LYS CB    HB2    sing N N 201 
LYS CB    HB3    sing N N 202 
LYS CG    CD     sing N N 203 
LYS CG    HG2    sing N N 204 
LYS CG    HG3    sing N N 205 
LYS CD    CE     sing N N 206 
LYS CD    HD2    sing N N 207 
LYS CD    HD3    sing N N 208 
LYS CE    NZ     sing N N 209 
LYS CE    HE2    sing N N 210 
LYS CE    HE3    sing N N 211 
LYS NZ    HZ1    sing N N 212 
LYS NZ    HZ2    sing N N 213 
LYS NZ    HZ3    sing N N 214 
LYS OXT   HXT    sing N N 215 
MET N     CA     sing N N 216 
MET N     H      sing N N 217 
MET N     H2     sing N N 218 
MET CA    C      sing N N 219 
MET CA    CB     sing N N 220 
MET CA    HA     sing N N 221 
MET C     O      doub N N 222 
MET C     OXT    sing N N 223 
MET CB    CG     sing N N 224 
MET CB    HB2    sing N N 225 
MET CB    HB3    sing N N 226 
MET CG    SD     sing N N 227 
MET CG    HG2    sing N N 228 
MET CG    HG3    sing N N 229 
MET SD    CE     sing N N 230 
MET CE    HE1    sing N N 231 
MET CE    HE2    sing N N 232 
MET CE    HE3    sing N N 233 
MET OXT   HXT    sing N N 234 
PHE N     CA     sing N N 235 
PHE N     H      sing N N 236 
PHE N     H2     sing N N 237 
PHE CA    C      sing N N 238 
PHE CA    CB     sing N N 239 
PHE CA    HA     sing N N 240 
PHE C     O      doub N N 241 
PHE C     OXT    sing N N 242 
PHE CB    CG     sing N N 243 
PHE CB    HB2    sing N N 244 
PHE CB    HB3    sing N N 245 
PHE CG    CD1    doub Y N 246 
PHE CG    CD2    sing Y N 247 
PHE CD1   CE1    sing Y N 248 
PHE CD1   HD1    sing N N 249 
PHE CD2   CE2    doub Y N 250 
PHE CD2   HD2    sing N N 251 
PHE CE1   CZ     doub Y N 252 
PHE CE1   HE1    sing N N 253 
PHE CE2   CZ     sing Y N 254 
PHE CE2   HE2    sing N N 255 
PHE CZ    HZ     sing N N 256 
PHE OXT   HXT    sing N N 257 
PRO N     CA     sing N N 258 
PRO N     CD     sing N N 259 
PRO N     H      sing N N 260 
PRO CA    C      sing N N 261 
PRO CA    CB     sing N N 262 
PRO CA    HA     sing N N 263 
PRO C     O      doub N N 264 
PRO C     OXT    sing N N 265 
PRO CB    CG     sing N N 266 
PRO CB    HB2    sing N N 267 
PRO CB    HB3    sing N N 268 
PRO CG    CD     sing N N 269 
PRO CG    HG2    sing N N 270 
PRO CG    HG3    sing N N 271 
PRO CD    HD2    sing N N 272 
PRO CD    HD3    sing N N 273 
PRO OXT   HXT    sing N N 274 
SER N     CA     sing N N 275 
SER N     H      sing N N 276 
SER N     H2     sing N N 277 
SER CA    C      sing N N 278 
SER CA    CB     sing N N 279 
SER CA    HA     sing N N 280 
SER C     O      doub N N 281 
SER C     OXT    sing N N 282 
SER CB    OG     sing N N 283 
SER CB    HB2    sing N N 284 
SER CB    HB3    sing N N 285 
SER OG    HG     sing N N 286 
SER OXT   HXT    sing N N 287 
THR N     CA     sing N N 288 
THR N     H      sing N N 289 
THR N     H2     sing N N 290 
THR CA    C      sing N N 291 
THR CA    CB     sing N N 292 
THR CA    HA     sing N N 293 
THR C     O      doub N N 294 
THR C     OXT    sing N N 295 
THR CB    OG1    sing N N 296 
THR CB    CG2    sing N N 297 
THR CB    HB     sing N N 298 
THR OG1   HG1    sing N N 299 
THR CG2   HG21   sing N N 300 
THR CG2   HG22   sing N N 301 
THR CG2   HG23   sing N N 302 
THR OXT   HXT    sing N N 303 
TRP N     CA     sing N N 304 
TRP N     H      sing N N 305 
TRP N     H2     sing N N 306 
TRP CA    C      sing N N 307 
TRP CA    CB     sing N N 308 
TRP CA    HA     sing N N 309 
TRP C     O      doub N N 310 
TRP C     OXT    sing N N 311 
TRP CB    CG     sing N N 312 
TRP CB    HB2    sing N N 313 
TRP CB    HB3    sing N N 314 
TRP CG    CD1    doub Y N 315 
TRP CG    CD2    sing Y N 316 
TRP CD1   NE1    sing Y N 317 
TRP CD1   HD1    sing N N 318 
TRP CD2   CE2    doub Y N 319 
TRP CD2   CE3    sing Y N 320 
TRP NE1   CE2    sing Y N 321 
TRP NE1   HE1    sing N N 322 
TRP CE2   CZ2    sing Y N 323 
TRP CE3   CZ3    doub Y N 324 
TRP CE3   HE3    sing N N 325 
TRP CZ2   CH2    doub Y N 326 
TRP CZ2   HZ2    sing N N 327 
TRP CZ3   CH2    sing Y N 328 
TRP CZ3   HZ3    sing N N 329 
TRP CH2   HH2    sing N N 330 
TRP OXT   HXT    sing N N 331 
TYR N     CA     sing N N 332 
TYR N     H      sing N N 333 
TYR N     H2     sing N N 334 
TYR CA    C      sing N N 335 
TYR CA    CB     sing N N 336 
TYR CA    HA     sing N N 337 
TYR C     O      doub N N 338 
TYR C     OXT    sing N N 339 
TYR CB    CG     sing N N 340 
TYR CB    HB2    sing N N 341 
TYR CB    HB3    sing N N 342 
TYR CG    CD1    doub Y N 343 
TYR CG    CD2    sing Y N 344 
TYR CD1   CE1    sing Y N 345 
TYR CD1   HD1    sing N N 346 
TYR CD2   CE2    doub Y N 347 
TYR CD2   HD2    sing N N 348 
TYR CE1   CZ     doub Y N 349 
TYR CE1   HE1    sing N N 350 
TYR CE2   CZ     sing Y N 351 
TYR CE2   HE2    sing N N 352 
TYR CZ    OH     sing N N 353 
TYR OH    HH     sing N N 354 
TYR OXT   HXT    sing N N 355 
UDP N1    C2     sing N N 356 
UDP N1    C6     sing N N 357 
UDP N1    "C1'"  sing N N 358 
UDP C2    N3     sing N N 359 
UDP C2    O2     doub N N 360 
UDP N3    C4     sing N N 361 
UDP N3    HN3    sing N N 362 
UDP C4    C5     sing N N 363 
UDP C4    O4     doub N N 364 
UDP C5    C6     doub N N 365 
UDP C5    H5     sing N N 366 
UDP C6    H6     sing N N 367 
UDP "C1'" "C2'"  sing N N 368 
UDP "C1'" "O4'"  sing N N 369 
UDP "C1'" "H1'"  sing N N 370 
UDP "C2'" "O2'"  sing N N 371 
UDP "C2'" "C3'"  sing N N 372 
UDP "C2'" "H2'"  sing N N 373 
UDP "O2'" "HO2'" sing N N 374 
UDP "C3'" "C4'"  sing N N 375 
UDP "C3'" "O3'"  sing N N 376 
UDP "C3'" "H3'"  sing N N 377 
UDP "C4'" "O4'"  sing N N 378 
UDP "C4'" "C5'"  sing N N 379 
UDP "C4'" "H4'"  sing N N 380 
UDP "O3'" "HO3'" sing N N 381 
UDP "C5'" "O5'"  sing N N 382 
UDP "C5'" "H5'1" sing N N 383 
UDP "C5'" "H5'2" sing N N 384 
UDP "O5'" PA     sing N N 385 
UDP PA    O1A    doub N N 386 
UDP PA    O2A    sing N N 387 
UDP PA    O3A    sing N N 388 
UDP O2A   HOA2   sing N N 389 
UDP O3A   PB     sing N N 390 
UDP PB    O1B    doub N N 391 
UDP PB    O2B    sing N N 392 
UDP PB    O3B    sing N N 393 
UDP O2B   HOB2   sing N N 394 
UDP O3B   HOB3   sing N N 395 
VAL N     CA     sing N N 396 
VAL N     H      sing N N 397 
VAL N     H2     sing N N 398 
VAL CA    C      sing N N 399 
VAL CA    CB     sing N N 400 
VAL CA    HA     sing N N 401 
VAL C     O      doub N N 402 
VAL C     OXT    sing N N 403 
VAL CB    CG1    sing N N 404 
VAL CB    CG2    sing N N 405 
VAL CB    HB     sing N N 406 
VAL CG1   HG11   sing N N 407 
VAL CG1   HG12   sing N N 408 
VAL CG1   HG13   sing N N 409 
VAL CG2   HG21   sing N N 410 
VAL CG2   HG22   sing N N 411 
VAL CG2   HG23   sing N N 412 
VAL OXT   HXT    sing N N 413 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-10-21 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9E1T 
_em_admin.last_update        2025-05-21 
_em_admin.map_release_date   2025-02-12 
_em_admin.title              'CryoEM structure of LARGE1 bound to UDP' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? cryoSPARC 4 
'IMAGE ACQUISITION'        ? 2  ? ? 1 SerialEM  ? 
MASKING                    ? 3  ? ? ? ?         ? 
'CTF CORRECTION'           ? 4  1 ? ? cryoSPARC 4 
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ? 
'MODEL FITTING'            ? 7  ? ? ? ?         ? 
'MODEL REFINEMENT'         ? 8  ? ? ? PHENIX    ? 
OTHER                      ? 9  ? ? ? ?         ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? cryoSPARC 4 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ?         ? 
CLASSIFICATION             ? 12 1 ? ? RELION    5 
RECONSTRUCTION             ? 13 1 ? ? ?         ? 
# 
_em_specimen.concentration           0.5 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Howard Hughes Medical Institute (HHMI)'                                                                                  
'United States' ?              1 
'National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)' 
'United States' 'U54 NS053672' 2 
'National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)' 
'United States' 'U24 GM129547' 3 
# 
_atom_sites.entry_id                    9E1T 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MN 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1     N  N     . LYS A 1 142 ? 94.048  108.883 70.649  1.00 99.27  ? 134 LYS A N     1 
ATOM   2     C  CA    . LYS A 1 142 ? 95.051  109.198 71.659  1.00 104.27 ? 134 LYS A CA    1 
ATOM   3     C  C     . LYS A 1 142 ? 94.457  109.137 73.061  1.00 107.84 ? 134 LYS A C     1 
ATOM   4     O  O     . LYS A 1 142 ? 95.019  108.507 73.956  1.00 108.55 ? 134 LYS A O     1 
ATOM   5     C  CB    . LYS A 1 142 ? 95.654  110.580 71.405  1.00 107.65 ? 134 LYS A CB    1 
ATOM   6     C  CG    . LYS A 1 142 ? 96.680  111.005 72.440  1.00 110.00 ? 134 LYS A CG    1 
ATOM   7     C  CD    . LYS A 1 142 ? 97.204  112.403 72.158  1.00 114.97 ? 134 LYS A CD    1 
ATOM   8     C  CE    . LYS A 1 142 ? 98.222  112.832 73.203  1.00 117.34 ? 134 LYS A CE    1 
ATOM   9     N  NZ    . LYS A 1 142 ? 98.733  114.207 72.949  1.00 120.26 ? 134 LYS A NZ    1 
ATOM   10    N  N     . CYS A 1 143 ? 93.316  109.801 73.248  1.00 107.60 ? 135 CYS A N     1 
ATOM   11    C  CA    . CYS A 1 143 ? 92.615  109.823 74.526  1.00 104.90 ? 135 CYS A CA    1 
ATOM   12    C  C     . CYS A 1 143 ? 91.400  108.903 74.533  1.00 97.21  ? 135 CYS A C     1 
ATOM   13    O  O     . CYS A 1 143 ? 90.390  109.213 75.174  1.00 95.60  ? 135 CYS A O     1 
ATOM   14    C  CB    . CYS A 1 143 ? 92.198  111.251 74.878  1.00 109.44 ? 135 CYS A CB    1 
ATOM   15    S  SG    . CYS A 1 143 ? 93.558  112.438 74.969  1.00 131.48 ? 135 CYS A SG    1 
ATOM   16    N  N     . GLU A 1 144 ? 91.474  107.778 73.826  1.00 89.67  ? 136 GLU A N     1 
ATOM   17    C  CA    . GLU A 1 144 ? 90.353  106.852 73.772  1.00 82.22  ? 136 GLU A CA    1 
ATOM   18    C  C     . GLU A 1 144 ? 90.112  106.220 75.137  1.00 81.44  ? 136 GLU A C     1 
ATOM   19    O  O     . GLU A 1 144 ? 91.049  105.795 75.817  1.00 82.65  ? 136 GLU A O     1 
ATOM   20    C  CB    . GLU A 1 144 ? 90.613  105.768 72.727  1.00 82.58  ? 136 GLU A CB    1 
ATOM   21    C  CG    . GLU A 1 144 ? 89.476  104.775 72.566  1.00 83.50  ? 136 GLU A CG    1 
ATOM   22    C  CD    . GLU A 1 144 ? 89.754  103.741 71.494  1.00 87.31  ? 136 GLU A CD    1 
ATOM   23    O  OE1   . GLU A 1 144 ? 90.796  103.853 70.815  1.00 88.66  ? 136 GLU A OE1   1 
ATOM   24    O  OE2   . GLU A 1 144 ? 88.931  102.816 71.331  1.00 85.35  ? 136 GLU A OE2   1 
ATOM   25    N  N     . THR A 1 145 ? 88.844  106.159 75.534  1.00 81.43  ? 137 THR A N     1 
ATOM   26    C  CA    . THR A 1 145 ? 88.493  105.615 76.839  1.00 74.99  ? 137 THR A CA    1 
ATOM   27    C  C     . THR A 1 145 ? 88.613  104.096 76.833  1.00 73.32  ? 137 THR A C     1 
ATOM   28    O  O     . THR A 1 145 ? 88.071  103.421 75.953  1.00 71.62  ? 137 THR A O     1 
ATOM   29    C  CB    . THR A 1 145 ? 87.075  106.033 77.222  1.00 74.19  ? 137 THR A CB    1 
ATOM   30    O  OG1   . THR A 1 145 ? 87.039  107.446 77.457  1.00 83.24  ? 137 THR A OG1   1 
ATOM   31    C  CG2   . THR A 1 145 ? 86.619  105.302 78.476  1.00 62.05  ? 137 THR A CG2   1 
ATOM   32    N  N     . ILE A 1 146 ? 89.322  103.562 77.823  1.00 74.33  ? 138 ILE A N     1 
ATOM   33    C  CA    . ILE A 1 146 ? 89.512  102.126 77.980  1.00 66.19  ? 138 ILE A CA    1 
ATOM   34    C  C     . ILE A 1 146 ? 88.606  101.655 79.108  1.00 60.19  ? 138 ILE A C     1 
ATOM   35    O  O     . ILE A 1 146 ? 88.668  102.181 80.225  1.00 57.85  ? 138 ILE A O     1 
ATOM   36    C  CB    . ILE A 1 146 ? 90.981  101.785 78.269  1.00 64.27  ? 138 ILE A CB    1 
ATOM   37    C  CG1   . ILE A 1 146 ? 91.868  102.257 77.116  1.00 63.63  ? 138 ILE A CG1   1 
ATOM   38    C  CG2   . ILE A 1 146 ? 91.148  100.293 78.499  1.00 61.91  ? 138 ILE A CG2   1 
ATOM   39    C  CD1   . ILE A 1 146 ? 93.341  102.068 77.368  1.00 68.32  ? 138 ILE A CD1   1 
ATOM   40    N  N     . HIS A 1 147 ? 87.766  100.666 78.819  1.00 57.62  ? 139 HIS A N     1 
ATOM   41    C  CA    . HIS A 1 147 ? 86.773  100.176 79.765  1.00 55.14  ? 139 HIS A CA    1 
ATOM   42    C  C     . HIS A 1 147 ? 87.263  98.875  80.387  1.00 45.81  ? 139 HIS A C     1 
ATOM   43    O  O     . HIS A 1 147 ? 87.575  97.919  79.671  1.00 47.02  ? 139 HIS A O     1 
ATOM   44    C  CB    . HIS A 1 147 ? 85.426  99.969  79.073  1.00 58.08  ? 139 HIS A CB    1 
ATOM   45    C  CG    . HIS A 1 147 ? 84.853  101.222 78.489  1.00 54.95  ? 139 HIS A CG    1 
ATOM   46    N  ND1   . HIS A 1 147 ? 83.773  101.875 79.043  1.00 52.77  ? 139 HIS A ND1   1 
ATOM   47    C  CD2   . HIS A 1 147 ? 85.212  101.946 77.403  1.00 58.53  ? 139 HIS A CD2   1 
ATOM   48    C  CE1   . HIS A 1 147 ? 83.491  102.944 78.322  1.00 58.91  ? 139 HIS A CE1   1 
ATOM   49    N  NE2   . HIS A 1 147 ? 84.349  103.010 77.320  1.00 60.12  ? 139 HIS A NE2   1 
ATOM   50    N  N     . VAL A 1 148 ? 87.323  98.845  81.716  1.00 45.64  ? 140 VAL A N     1 
ATOM   51    C  CA    . VAL A 1 148 ? 87.798  97.690  82.469  1.00 43.55  ? 140 VAL A CA    1 
ATOM   52    C  C     . VAL A 1 148 ? 86.683  97.244  83.402  1.00 45.25  ? 140 VAL A C     1 
ATOM   53    O  O     . VAL A 1 148 ? 86.193  98.038  84.211  1.00 46.94  ? 140 VAL A O     1 
ATOM   54    C  CB    . VAL A 1 148 ? 89.072  98.011  83.265  1.00 42.09  ? 140 VAL A CB    1 
ATOM   55    C  CG1   . VAL A 1 148 ? 89.639  96.746  83.878  1.00 43.64  ? 140 VAL A CG1   1 
ATOM   56    C  CG2   . VAL A 1 148 ? 90.098  98.694  82.380  1.00 45.50  ? 140 VAL A CG2   1 
ATOM   57    N  N     . ALA A 1 149 ? 86.300  95.977  83.304  1.00 43.12  ? 141 ALA A N     1 
ATOM   58    C  CA    . ALA A 1 149 ? 85.236  95.400  84.116  1.00 39.20  ? 141 ALA A CA    1 
ATOM   59    C  C     . ALA A 1 149 ? 85.850  94.484  85.165  1.00 40.59  ? 141 ALA A C     1 
ATOM   60    O  O     . ALA A 1 149 ? 86.582  93.546  84.827  1.00 46.40  ? 141 ALA A O     1 
ATOM   61    C  CB    . ALA A 1 149 ? 84.239  94.633  83.248  1.00 44.36  ? 141 ALA A CB    1 
ATOM   62    N  N     . ILE A 1 150 ? 85.538  94.748  86.432  1.00 42.89  ? 142 ILE A N     1 
ATOM   63    C  CA    . ILE A 1 150 ? 86.086  93.997  87.555  1.00 42.14  ? 142 ILE A CA    1 
ATOM   64    C  C     . ILE A 1 150 ? 84.939  93.546  88.447  1.00 44.63  ? 142 ILE A C     1 
ATOM   65    O  O     . ILE A 1 150 ? 84.026  94.324  88.740  1.00 47.19  ? 142 ILE A O     1 
ATOM   66    C  CB    . ILE A 1 150 ? 87.100  94.834  88.363  1.00 39.58  ? 142 ILE A CB    1 
ATOM   67    C  CG1   . ILE A 1 150 ? 88.087  95.534  87.429  1.00 41.82  ? 142 ILE A CG1   1 
ATOM   68    C  CG2   . ILE A 1 150 ? 87.850  93.954  89.344  1.00 37.37  ? 142 ILE A CG2   1 
ATOM   69    C  CD1   . ILE A 1 150 ? 89.042  96.458  88.136  1.00 44.32  ? 142 ILE A CD1   1 
ATOM   70    N  N     . VAL A 1 151 ? 84.986  92.289  88.877  1.00 44.13  ? 143 VAL A N     1 
ATOM   71    C  CA    . VAL A 1 151 ? 83.998  91.730  89.791  1.00 46.97  ? 143 VAL A CA    1 
ATOM   72    C  C     . VAL A 1 151 ? 84.624  91.667  91.177  1.00 52.27  ? 143 VAL A C     1 
ATOM   73    O  O     . VAL A 1 151 ? 85.663  91.025  91.369  1.00 57.59  ? 143 VAL A O     1 
ATOM   74    C  CB    . VAL A 1 151 ? 83.530  90.341  89.332  1.00 49.82  ? 143 VAL A CB    1 
ATOM   75    C  CG1   . VAL A 1 151 ? 82.519  89.772  90.313  1.00 52.90  ? 143 VAL A CG1   1 
ATOM   76    C  CG2   . VAL A 1 151 ? 82.940  90.418  87.936  1.00 56.12  ? 143 VAL A CG2   1 
ATOM   77    N  N     . CYS A 1 152 ? 83.996  92.331  92.146  1.00 53.75  ? 144 CYS A N     1 
ATOM   78    C  CA    . CYS A 1 152 ? 84.526  92.426  93.499  1.00 54.60  ? 144 CYS A CA    1 
ATOM   79    C  C     . CYS A 1 152 ? 83.451  92.045  94.506  1.00 61.46  ? 144 CYS A C     1 
ATOM   80    O  O     . CYS A 1 152 ? 82.280  92.393  94.335  1.00 61.15  ? 144 CYS A O     1 
ATOM   81    C  CB    . CYS A 1 152 ? 85.042  93.838  93.790  1.00 49.94  ? 144 CYS A CB    1 
ATOM   82    S  SG    . CYS A 1 152 ? 85.721  94.055  95.446  1.00 71.10  ? 144 CYS A SG    1 
ATOM   83    N  N     . ALA A 1 153 ? 83.853  91.329  95.556  1.00 60.39  ? 145 ALA A N     1 
ATOM   84    C  CA    . ALA A 1 153 ? 82.908  90.907  96.589  1.00 60.47  ? 145 ALA A CA    1 
ATOM   85    C  C     . ALA A 1 153 ? 83.683  90.593  97.862  1.00 63.72  ? 145 ALA A C     1 
ATOM   86    O  O     . ALA A 1 153 ? 84.420  89.603  97.907  1.00 65.50  ? 145 ALA A O     1 
ATOM   87    C  CB    . ALA A 1 153 ? 82.105  89.700  96.126  1.00 71.00  ? 145 ALA A CB    1 
ATOM   88    N  N     . GLY A 1 154 ? 83.505  91.417  98.888  1.00 64.67  ? 146 GLY A N     1 
ATOM   89    C  CA    . GLY A 1 154 ? 84.148  91.211  100.168 1.00 55.82  ? 146 GLY A CA    1 
ATOM   90    C  C     . GLY A 1 154 ? 85.272  92.202  100.421 1.00 52.28  ? 146 GLY A C     1 
ATOM   91    O  O     . GLY A 1 154 ? 85.690  92.968  99.551  1.00 53.31  ? 146 GLY A O     1 
ATOM   92    N  N     . TYR A 1 155 ? 85.771  92.169  101.658 1.00 50.90  ? 147 TYR A N     1 
ATOM   93    C  CA    . TYR A 1 155 ? 86.835  93.083  102.059 1.00 47.79  ? 147 TYR A CA    1 
ATOM   94    C  C     . TYR A 1 155 ? 88.180  92.657  101.480 1.00 48.02  ? 147 TYR A C     1 
ATOM   95    O  O     . TYR A 1 155 ? 88.983  93.504  101.065 1.00 47.77  ? 147 TYR A O     1 
ATOM   96    C  CB    . TYR A 1 155 ? 86.897  93.163  103.583 1.00 42.66  ? 147 TYR A CB    1 
ATOM   97    C  CG    . TYR A 1 155 ? 85.532  93.239  104.231 1.00 46.14  ? 147 TYR A CG    1 
ATOM   98    C  CD1   . TYR A 1 155 ? 84.921  94.460  104.463 1.00 42.49  ? 147 TYR A CD1   1 
ATOM   99    C  CD2   . TYR A 1 155 ? 84.852  92.087  104.603 1.00 48.96  ? 147 TYR A CD2   1 
ATOM   100   C  CE1   . TYR A 1 155 ? 83.675  94.535  105.047 1.00 43.61  ? 147 TYR A CE1   1 
ATOM   101   C  CE2   . TYR A 1 155 ? 83.605  92.152  105.188 1.00 51.67  ? 147 TYR A CE2   1 
ATOM   102   C  CZ    . TYR A 1 155 ? 83.022  93.379  105.410 1.00 50.90  ? 147 TYR A CZ    1 
ATOM   103   O  OH    . TYR A 1 155 ? 81.780  93.451  105.994 1.00 56.36  ? 147 TYR A OH    1 
ATOM   104   N  N     . ASN A 1 156 ? 88.445  91.350  101.449 1.00 45.35  ? 148 ASN A N     1 
ATOM   105   C  CA    . ASN A 1 156 ? 89.658  90.864  100.801 1.00 47.30  ? 148 ASN A CA    1 
ATOM   106   C  C     . ASN A 1 156 ? 89.651  91.208  99.318  1.00 50.20  ? 148 ASN A C     1 
ATOM   107   O  O     . ASN A 1 156 ? 90.666  91.656  98.768  1.00 53.16  ? 148 ASN A O     1 
ATOM   108   C  CB    . ASN A 1 156 ? 89.792  89.355  101.005 1.00 51.17  ? 148 ASN A CB    1 
ATOM   109   C  CG    . ASN A 1 156 ? 89.898  88.971  102.468 1.00 52.26  ? 148 ASN A CG    1 
ATOM   110   O  OD1   . ASN A 1 156 ? 90.479  89.699  103.273 1.00 55.71  ? 148 ASN A OD1   1 
ATOM   111   N  ND2   . ASN A 1 156 ? 89.338  87.820  102.820 1.00 51.70  ? 148 ASN A ND2   1 
ATOM   112   N  N     . ALA A 1 157 ? 88.506  91.020  98.658  1.00 47.87  ? 149 ALA A N     1 
ATOM   113   C  CA    . ALA A 1 157 ? 88.390  91.396  97.255  1.00 48.97  ? 149 ALA A CA    1 
ATOM   114   C  C     . ALA A 1 157 ? 88.524  92.900  97.077  1.00 47.14  ? 149 ALA A C     1 
ATOM   115   O  O     . ALA A 1 157 ? 89.046  93.365  96.061  1.00 46.62  ? 149 ALA A O     1 
ATOM   116   C  CB    . ALA A 1 157 ? 87.062  90.903  96.686  1.00 52.65  ? 149 ALA A CB    1 
ATOM   117   N  N     . SER A 1 158 ? 88.052  93.681  98.052  1.00 45.67  ? 150 SER A N     1 
ATOM   118   C  CA    . SER A 1 158 ? 88.215  95.129  97.978  1.00 40.07  ? 150 SER A CA    1 
ATOM   119   C  C     . SER A 1 158 ? 89.686  95.521  98.038  1.00 40.40  ? 150 SER A C     1 
ATOM   120   O  O     . SER A 1 158 ? 90.144  96.364  97.260  1.00 45.28  ? 150 SER A O     1 
ATOM   121   C  CB    . SER A 1 158 ? 87.432  95.801  99.102  1.00 39.17  ? 150 SER A CB    1 
ATOM   122   O  OG    . SER A 1 158 ? 86.064  95.437  99.051  1.00 42.40  ? 150 SER A OG    1 
ATOM   123   N  N     . ARG A 1 159 ? 90.446  94.909  98.946  1.00 38.44  ? 151 ARG A N     1 
ATOM   124   C  CA    . ARG A 1 159 ? 91.881  95.180  98.996  1.00 40.16  ? 151 ARG A CA    1 
ATOM   125   C  C     . ARG A 1 159 ? 92.563  94.756  97.700  1.00 44.20  ? 151 ARG A C     1 
ATOM   126   O  O     . ARG A 1 159 ? 93.423  95.475  97.168  1.00 44.20  ? 151 ARG A O     1 
ATOM   127   C  CB    . ARG A 1 159 ? 92.516  94.469  100.190 1.00 41.20  ? 151 ARG A CB    1 
ATOM   128   C  CG    . ARG A 1 159 ? 92.018  94.941  101.544 1.00 38.12  ? 151 ARG A CG    1 
ATOM   129   C  CD    . ARG A 1 159 ? 92.943  94.476  102.659 1.00 35.10  ? 151 ARG A CD    1 
ATOM   130   N  NE    . ARG A 1 159 ? 93.176  93.038  102.615 1.00 40.83  ? 151 ARG A NE    1 
ATOM   131   C  CZ    . ARG A 1 159 ? 92.436  92.139  103.247 1.00 40.75  ? 151 ARG A CZ    1 
ATOM   132   N  NH1   . ARG A 1 159 ? 91.402  92.494  103.991 1.00 36.57  ? 151 ARG A NH1   1 
ATOM   133   N  NH2   . ARG A 1 159 ? 92.739  90.850  103.129 1.00 45.20  ? 151 ARG A NH2   1 
ATOM   134   N  N     . ASP A 1 160 ? 92.185  93.589  97.172  1.00 46.18  ? 152 ASP A N     1 
ATOM   135   C  CA    . ASP A 1 160 ? 92.784  93.109  95.932  1.00 46.27  ? 152 ASP A CA    1 
ATOM   136   C  C     . ASP A 1 160 ? 92.480  94.043  94.767  1.00 47.06  ? 152 ASP A C     1 
ATOM   137   O  O     . ASP A 1 160 ? 93.357  94.315  93.940  1.00 51.28  ? 152 ASP A O     1 
ATOM   138   C  CB    . ASP A 1 160 ? 92.295  91.695  95.628  1.00 50.55  ? 152 ASP A CB    1 
ATOM   139   C  CG    . ASP A 1 160 ? 92.813  90.673  96.618  1.00 58.91  ? 152 ASP A CG    1 
ATOM   140   O  OD1   . ASP A 1 160 ? 93.888  90.905  97.209  1.00 62.41  ? 152 ASP A OD1   1 
ATOM   141   O  OD2   . ASP A 1 160 ? 92.146  89.633  96.802  1.00 61.79  ? 152 ASP A OD2   1 
ATOM   142   N  N     . VAL A 1 161 ? 91.244  94.538  94.674  1.00 44.66  ? 153 VAL A N     1 
ATOM   143   C  CA    . VAL A 1 161 ? 90.901  95.428  93.572  1.00 42.14  ? 153 VAL A CA    1 
ATOM   144   C  C     . VAL A 1 161 ? 91.566  96.784  93.756  1.00 41.30  ? 153 VAL A C     1 
ATOM   145   O  O     . VAL A 1 161 ? 91.888  97.455  92.773  1.00 44.26  ? 153 VAL A O     1 
ATOM   146   C  CB    . VAL A 1 161 ? 89.373  95.548  93.406  1.00 38.67  ? 153 VAL A CB    1 
ATOM   147   C  CG1   . VAL A 1 161 ? 88.757  96.314  94.545  1.00 42.02  ? 153 VAL A CG1   1 
ATOM   148   C  CG2   . VAL A 1 161 ? 89.033  96.213  92.083  1.00 39.78  ? 153 VAL A CG2   1 
ATOM   149   N  N     . VAL A 1 162 ? 91.808  97.207  94.999  1.00 42.04  ? 154 VAL A N     1 
ATOM   150   C  CA    . VAL A 1 162 ? 92.604  98.415  95.216  1.00 44.31  ? 154 VAL A CA    1 
ATOM   151   C  C     . VAL A 1 162 ? 94.008  98.223  94.659  1.00 46.71  ? 154 VAL A C     1 
ATOM   152   O  O     . VAL A 1 162 ? 94.552  99.098  93.972  1.00 49.67  ? 154 VAL A O     1 
ATOM   153   C  CB    . VAL A 1 162 ? 92.641  98.781  96.710  1.00 42.73  ? 154 VAL A CB    1 
ATOM   154   C  CG1   . VAL A 1 162 ? 93.659  99.881  96.956  1.00 45.24  ? 154 VAL A CG1   1 
ATOM   155   C  CG2   . VAL A 1 162 ? 91.278  99.221  97.178  1.00 41.25  ? 154 VAL A CG2   1 
ATOM   156   N  N     . THR A 1 163 ? 94.613  97.068  94.946  1.00 45.06  ? 155 THR A N     1 
ATOM   157   C  CA    . THR A 1 163 ? 95.945  96.785  94.417  1.00 45.06  ? 155 THR A CA    1 
ATOM   158   C  C     . THR A 1 163 ? 95.938  96.754  92.891  1.00 48.31  ? 155 THR A C     1 
ATOM   159   O  O     . THR A 1 163 ? 96.836  97.307  92.242  1.00 52.03  ? 155 THR A O     1 
ATOM   160   C  CB    . THR A 1 163 ? 96.462  95.460  94.975  1.00 48.40  ? 155 THR A CB    1 
ATOM   161   O  OG1   . THR A 1 163 ? 96.456  95.508  96.406  1.00 52.93  ? 155 THR A OG1   1 
ATOM   162   C  CG2   . THR A 1 163 ? 97.877  95.195  94.493  1.00 58.02  ? 155 THR A CG2   1 
ATOM   163   N  N     . LEU A 1 164 ? 94.924  96.114  92.305  1.00 46.59  ? 156 LEU A N     1 
ATOM   164   C  CA    . LEU A 1 164 ? 94.824  96.034  90.851  1.00 42.73  ? 156 LEU A CA    1 
ATOM   165   C  C     . LEU A 1 164 ? 94.657  97.414  90.227  1.00 43.07  ? 156 LEU A C     1 
ATOM   166   O  O     . LEU A 1 164 ? 95.271  97.715  89.198  1.00 46.10  ? 156 LEU A O     1 
ATOM   167   C  CB    . LEU A 1 164 ? 93.660  95.125  90.460  1.00 41.34  ? 156 LEU A CB    1 
ATOM   168   C  CG    . LEU A 1 164 ? 93.156  95.208  89.018  1.00 41.65  ? 156 LEU A CG    1 
ATOM   169   C  CD1   . LEU A 1 164 ? 94.237  94.804  88.033  1.00 45.70  ? 156 LEU A CD1   1 
ATOM   170   C  CD2   . LEU A 1 164 ? 91.928  94.340  88.844  1.00 41.88  ? 156 LEU A CD2   1 
ATOM   171   N  N     . VAL A 1 165 ? 93.820  98.261  90.827  1.00 41.98  ? 157 VAL A N     1 
ATOM   172   C  CA    . VAL A 1 165 ? 93.614  99.603  90.300  1.00 42.18  ? 157 VAL A CA    1 
ATOM   173   C  C     . VAL A 1 165 ? 94.893  100.420 90.406  1.00 43.88  ? 157 VAL A C     1 
ATOM   174   O  O     . VAL A 1 165 ? 95.231  101.182 89.495  1.00 47.31  ? 157 VAL A O     1 
ATOM   175   C  CB    . VAL A 1 165 ? 92.433  100.283 91.017  1.00 42.01  ? 157 VAL A CB    1 
ATOM   176   C  CG1   . VAL A 1 165 ? 92.397  101.766 90.703  1.00 42.93  ? 157 VAL A CG1   1 
ATOM   177   C  CG2   . VAL A 1 165 ? 91.127  99.632  90.602  1.00 38.65  ? 157 VAL A CG2   1 
ATOM   178   N  N     . LYS A 1 166 ? 95.631  100.276 91.510  1.00 40.12  ? 158 LYS A N     1 
ATOM   179   C  CA    . LYS A 1 166 ? 96.915  100.962 91.617  1.00 42.02  ? 158 LYS A CA    1 
ATOM   180   C  C     . LYS A 1 166 ? 97.874  100.504 90.526  1.00 52.90  ? 158 LYS A C     1 
ATOM   181   O  O     . LYS A 1 166 ? 98.554  101.326 89.897  1.00 60.90  ? 158 LYS A O     1 
ATOM   182   C  CB    . LYS A 1 166 ? 97.531  100.728 92.996  1.00 49.80  ? 158 LYS A CB    1 
ATOM   183   C  CG    . LYS A 1 166 ? 96.874  101.503 94.120  1.00 52.26  ? 158 LYS A CG    1 
ATOM   184   C  CD    . LYS A 1 166 ? 97.609  101.278 95.429  1.00 43.50  ? 158 LYS A CD    1 
ATOM   185   C  CE    . LYS A 1 166 ? 97.025  102.126 96.542  1.00 57.95  ? 158 LYS A CE    1 
ATOM   186   N  NZ    . LYS A 1 166 ? 97.684  101.850 97.848  1.00 66.58  ? 158 LYS A NZ    1 
ATOM   187   N  N     . SER A 1 167 ? 97.934  99.192  90.280  1.00 52.79  ? 159 SER A N     1 
ATOM   188   C  CA    . SER A 1 167 ? 98.822  98.675  89.244  1.00 53.75  ? 159 SER A CA    1 
ATOM   189   C  C     . SER A 1 167 ? 98.434  99.203  87.869  1.00 54.61  ? 159 SER A C     1 
ATOM   190   O  O     . SER A 1 167 ? 99.301  99.588  87.076  1.00 58.45  ? 159 SER A O     1 
ATOM   191   C  CB    . SER A 1 167 ? 98.805  97.148  89.251  1.00 52.75  ? 159 SER A CB    1 
ATOM   192   O  OG    . SER A 1 167 ? 97.533  96.656  88.870  1.00 48.55  ? 159 SER A OG    1 
ATOM   193   N  N     . VAL A 1 168 ? 97.135  99.226  87.568  1.00 51.24  ? 160 VAL A N     1 
ATOM   194   C  CA    . VAL A 1 168 ? 96.676  99.717  86.272  1.00 50.94  ? 160 VAL A CA    1 
ATOM   195   C  C     . VAL A 1 168 ? 96.971  101.204 86.124  1.00 55.97  ? 160 VAL A C     1 
ATOM   196   O  O     . VAL A 1 168 ? 97.425  101.659 85.068  1.00 65.18  ? 160 VAL A O     1 
ATOM   197   C  CB    . VAL A 1 168 ? 95.178  99.414  86.084  1.00 49.70  ? 160 VAL A CB    1 
ATOM   198   C  CG1   . VAL A 1 168 ? 94.655  100.079 84.826  1.00 48.51  ? 160 VAL A CG1   1 
ATOM   199   C  CG2   . VAL A 1 168 ? 94.948  97.916  86.020  1.00 44.65  ? 160 VAL A CG2   1 
ATOM   200   N  N     . LEU A 1 169 ? 96.727  101.984 87.179  1.00 51.04  ? 161 LEU A N     1 
ATOM   201   C  CA    . LEU A 1 169 ? 96.923  103.426 87.095  1.00 56.38  ? 161 LEU A CA    1 
ATOM   202   C  C     . LEU A 1 169 ? 98.397  103.797 87.022  1.00 60.65  ? 161 LEU A C     1 
ATOM   203   O  O     . LEU A 1 169 ? 98.738  104.856 86.484  1.00 67.72  ? 161 LEU A O     1 
ATOM   204   C  CB    . LEU A 1 169 ? 96.265  104.118 88.288  1.00 58.93  ? 161 LEU A CB    1 
ATOM   205   C  CG    . LEU A 1 169 ? 94.737  104.110 88.333  1.00 58.07  ? 161 LEU A CG    1 
ATOM   206   C  CD1   . LEU A 1 169 ? 94.233  104.761 89.608  1.00 54.99  ? 161 LEU A CD1   1 
ATOM   207   C  CD2   . LEU A 1 169 ? 94.169  104.813 87.120  1.00 59.89  ? 161 LEU A CD2   1 
ATOM   208   N  N     . PHE A 1 170 ? 99.284  102.956 87.559  1.00 60.28  ? 162 PHE A N     1 
ATOM   209   C  CA    . PHE A 1 170 ? 100.705 103.274 87.496  1.00 66.55  ? 162 PHE A CA    1 
ATOM   210   C  C     . PHE A 1 170 ? 101.250 103.244 86.072  1.00 68.66  ? 162 PHE A C     1 
ATOM   211   O  O     . PHE A 1 170 ? 102.284 103.867 85.806  1.00 69.72  ? 162 PHE A O     1 
ATOM   212   C  CB    . PHE A 1 170 ? 101.503 102.314 88.378  1.00 71.87  ? 162 PHE A CB    1 
ATOM   213   C  CG    . PHE A 1 170 ? 102.932 102.728 88.585  1.00 79.64  ? 162 PHE A CG    1 
ATOM   214   C  CD1   . PHE A 1 170 ? 103.253 103.718 89.497  1.00 79.58  ? 162 PHE A CD1   1 
ATOM   215   C  CD2   . PHE A 1 170 ? 103.954 102.127 87.868  1.00 74.77  ? 162 PHE A CD2   1 
ATOM   216   C  CE1   . PHE A 1 170 ? 104.566 104.103 89.690  1.00 77.63  ? 162 PHE A CE1   1 
ATOM   217   C  CE2   . PHE A 1 170 ? 105.268 102.507 88.056  1.00 75.23  ? 162 PHE A CE2   1 
ATOM   218   C  CZ    . PHE A 1 170 ? 105.574 103.496 88.968  1.00 78.51  ? 162 PHE A CZ    1 
ATOM   219   N  N     . HIS A 1 171 ? 100.581 102.548 85.153  1.00 66.30  ? 163 HIS A N     1 
ATOM   220   C  CA    . HIS A 1 171 ? 101.046 102.430 83.779  1.00 66.72  ? 163 HIS A CA    1 
ATOM   221   C  C     . HIS A 1 171 ? 100.098 103.037 82.754  1.00 69.82  ? 163 HIS A C     1 
ATOM   222   O  O     . HIS A 1 171 ? 100.406 103.004 81.558  1.00 72.40  ? 163 HIS A O     1 
ATOM   223   C  CB    . HIS A 1 171 ? 101.284 100.957 83.420  1.00 69.67  ? 163 HIS A CB    1 
ATOM   224   C  CG    . HIS A 1 171 ? 102.366 100.303 84.220  1.00 71.62  ? 163 HIS A CG    1 
ATOM   225   N  ND1   . HIS A 1 171 ? 102.200 99.938  85.539  1.00 71.28  ? 163 HIS A ND1   1 
ATOM   226   C  CD2   . HIS A 1 171 ? 103.626 99.940  83.886  1.00 70.13  ? 163 HIS A CD2   1 
ATOM   227   C  CE1   . HIS A 1 171 ? 103.313 99.381  85.983  1.00 73.12  ? 163 HIS A CE1   1 
ATOM   228   N  NE2   . HIS A 1 171 ? 104.194 99.371  84.999  1.00 74.83  ? 163 HIS A NE2   1 
ATOM   229   N  N     . ARG A 1 172 ? 98.964  103.588 83.177  1.00 68.89  ? 164 ARG A N     1 
ATOM   230   C  CA    . ARG A 1 172 ? 97.958  104.052 82.232  1.00 68.26  ? 164 ARG A CA    1 
ATOM   231   C  C     . ARG A 1 172 ? 98.440  105.278 81.464  1.00 76.82  ? 164 ARG A C     1 
ATOM   232   O  O     . ARG A 1 172 ? 99.253  106.069 81.949  1.00 81.99  ? 164 ARG A O     1 
ATOM   233   C  CB    . ARG A 1 172 ? 96.656  104.389 82.956  1.00 67.25  ? 164 ARG A CB    1 
ATOM   234   C  CG    . ARG A 1 172 ? 96.764  105.597 83.867  1.00 66.39  ? 164 ARG A CG    1 
ATOM   235   C  CD    . ARG A 1 172 ? 95.430  106.298 84.023  1.00 62.52  ? 164 ARG A CD    1 
ATOM   236   N  NE    . ARG A 1 172 ? 95.553  107.505 84.828  1.00 64.47  ? 164 ARG A NE    1 
ATOM   237   C  CZ    . ARG A 1 172 ? 94.559  108.348 85.071  1.00 70.38  ? 164 ARG A CZ    1 
ATOM   238   N  NH1   . ARG A 1 172 ? 93.348  108.146 84.580  1.00 67.70  ? 164 ARG A NH1   1 
ATOM   239   N  NH2   . ARG A 1 172 ? 94.787  109.420 85.823  1.00 71.02  ? 164 ARG A NH2   1 
ATOM   240   N  N     . ARG A 1 173 ? 97.927  105.421 80.239  1.00 78.01  ? 165 ARG A N     1 
ATOM   241   C  CA    . ARG A 1 173 ? 98.142  106.620 79.443  1.00 78.13  ? 165 ARG A CA    1 
ATOM   242   C  C     . ARG A 1 173 ? 96.877  107.104 78.749  1.00 82.15  ? 165 ARG A C     1 
ATOM   243   O  O     . ARG A 1 173 ? 96.940  108.095 78.014  1.00 87.06  ? 165 ARG A O     1 
ATOM   244   C  CB    . ARG A 1 173 ? 99.239  106.384 78.390  1.00 80.92  ? 165 ARG A CB    1 
ATOM   245   C  CG    . ARG A 1 173 ? 100.611 106.091 78.973  1.00 80.48  ? 165 ARG A CG    1 
ATOM   246   C  CD    . ARG A 1 173 ? 101.632 105.833 77.881  1.00 89.25  ? 165 ARG A CD    1 
ATOM   247   N  NE    . ARG A 1 173 ? 102.898 105.357 78.425  1.00 93.30  ? 165 ARG A NE    1 
ATOM   248   C  CZ    . ARG A 1 173 ? 103.942 104.999 77.689  1.00 93.01  ? 165 ARG A CZ    1 
ATOM   249   N  NH1   . ARG A 1 173 ? 103.909 105.059 76.368  1.00 89.00  ? 165 ARG A NH1   1 
ATOM   250   N  NH2   . ARG A 1 173 ? 105.044 104.567 78.294  1.00 91.00  ? 165 ARG A NH2   1 
ATOM   251   N  N     . ASN A 1 174 ? 95.745  106.448 78.955  1.00 78.96  ? 166 ASN A N     1 
ATOM   252   C  CA    . ASN A 1 174 ? 94.470  106.779 78.341  1.00 77.56  ? 166 ASN A CA    1 
ATOM   253   C  C     . ASN A 1 174 ? 93.397  106.826 79.414  1.00 78.83  ? 166 ASN A C     1 
ATOM   254   O  O     . ASN A 1 174 ? 93.564  106.250 80.494  1.00 78.55  ? 166 ASN A O     1 
ATOM   255   C  CB    . ASN A 1 174 ? 94.095  105.747 77.267  1.00 80.82  ? 166 ASN A CB    1 
ATOM   256   C  CG    . ASN A 1 174 ? 95.033  105.777 76.078  1.00 89.81  ? 166 ASN A CG    1 
ATOM   257   O  OD1   . ASN A 1 174 ? 96.163  105.299 76.154  1.00 90.66  ? 166 ASN A OD1   1 
ATOM   258   N  ND2   . ASN A 1 174 ? 94.565  106.335 74.969  1.00 96.04  ? 166 ASN A ND2   1 
ATOM   259   N  N     . PRO A 1 175 ? 92.286  107.521 79.158  1.00 78.98  ? 167 PRO A N     1 
ATOM   260   C  CA    . PRO A 1 175 ? 91.204  107.565 80.150  1.00 72.63  ? 167 PRO A CA    1 
ATOM   261   C  C     . PRO A 1 175 ? 90.686  106.172 80.475  1.00 67.85  ? 167 PRO A C     1 
ATOM   262   O  O     . PRO A 1 175 ? 90.624  105.294 79.613  1.00 69.15  ? 167 PRO A O     1 
ATOM   263   C  CB    . PRO A 1 175 ? 90.133  108.419 79.464  1.00 74.28  ? 167 PRO A CB    1 
ATOM   264   C  CG    . PRO A 1 175 ? 90.898  109.281 78.526  1.00 81.04  ? 167 PRO A CG    1 
ATOM   265   C  CD    . PRO A 1 175 ? 92.034  108.434 78.030  1.00 79.66  ? 167 PRO A CD    1 
ATOM   266   N  N     . LEU A 1 176 ? 90.316  105.977 81.738  1.00 62.57  ? 168 LEU A N     1 
ATOM   267   C  CA    . LEU A 1 176 ? 89.902  104.678 82.248  1.00 57.86  ? 168 LEU A CA    1 
ATOM   268   C  C     . LEU A 1 176 ? 88.486  104.755 82.796  1.00 54.40  ? 168 LEU A C     1 
ATOM   269   O  O     . LEU A 1 176 ? 88.143  105.692 83.528  1.00 56.97  ? 168 LEU A O     1 
ATOM   270   C  CB    . LEU A 1 176 ? 90.863  104.184 83.331  1.00 56.92  ? 168 LEU A CB    1 
ATOM   271   C  CG    . LEU A 1 176 ? 92.194  103.624 82.831  1.00 55.90  ? 168 LEU A CG    1 
ATOM   272   C  CD1   . LEU A 1 176 ? 93.131  103.355 83.988  1.00 55.99  ? 168 LEU A CD1   1 
ATOM   273   C  CD2   . LEU A 1 176 ? 91.961  102.354 82.034  1.00 58.55  ? 168 LEU A CD2   1 
ATOM   274   N  N     . HIS A 1 177 ? 87.672  103.764 82.443  1.00 52.55  ? 169 HIS A N     1 
ATOM   275   C  CA    . HIS A 1 177 ? 86.304  103.639 82.927  1.00 49.86  ? 169 HIS A CA    1 
ATOM   276   C  C     . HIS A 1 177 ? 86.165  102.264 83.568  1.00 47.10  ? 169 HIS A C     1 
ATOM   277   O  O     . HIS A 1 177 ? 86.163  101.244 82.870  1.00 51.29  ? 169 HIS A O     1 
ATOM   278   C  CB    . HIS A 1 177 ? 85.300  103.832 81.792  1.00 51.62  ? 169 HIS A CB    1 
ATOM   279   C  CG    . HIS A 1 177 ? 83.882  103.971 82.250  1.00 54.13  ? 169 HIS A CG    1 
ATOM   280   N  ND1   . HIS A 1 177 ? 82.971  104.781 81.608  1.00 57.03  ? 169 HIS A ND1   1 
ATOM   281   C  CD2   . HIS A 1 177 ? 83.214  103.398 83.279  1.00 53.53  ? 169 HIS A CD2   1 
ATOM   282   C  CE1   . HIS A 1 177 ? 81.805  104.706 82.225  1.00 58.41  ? 169 HIS A CE1   1 
ATOM   283   N  NE2   . HIS A 1 177 ? 81.926  103.872 83.243  1.00 55.96  ? 169 HIS A NE2   1 
ATOM   284   N  N     . PHE A 1 178 ? 86.050  102.242 84.890  1.00 44.51  ? 170 PHE A N     1 
ATOM   285   C  CA    . PHE A 1 178 ? 85.912  101.004 85.639  1.00 41.22  ? 170 PHE A CA    1 
ATOM   286   C  C     . PHE A 1 178 ? 84.439  100.675 85.836  1.00 41.83  ? 170 PHE A C     1 
ATOM   287   O  O     . PHE A 1 178 ? 83.640  101.545 86.196  1.00 51.19  ? 170 PHE A O     1 
ATOM   288   C  CB    . PHE A 1 178 ? 86.616  101.107 86.992  1.00 41.12  ? 170 PHE A CB    1 
ATOM   289   C  CG    . PHE A 1 178 ? 88.107  101.229 86.891  1.00 43.50  ? 170 PHE A CG    1 
ATOM   290   C  CD1   . PHE A 1 178 ? 88.889  100.118 86.633  1.00 43.08  ? 170 PHE A CD1   1 
ATOM   291   C  CD2   . PHE A 1 178 ? 88.729  102.452 87.060  1.00 44.48  ? 170 PHE A CD2   1 
ATOM   292   C  CE1   . PHE A 1 178 ? 90.260  100.226 86.541  1.00 40.60  ? 170 PHE A CE1   1 
ATOM   293   C  CE2   . PHE A 1 178 ? 90.100  102.565 86.969  1.00 45.18  ? 170 PHE A CE2   1 
ATOM   294   C  CZ    . PHE A 1 178 ? 90.866  101.451 86.710  1.00 42.27  ? 170 PHE A CZ    1 
ATOM   295   N  N     . HIS A 1 179 ? 84.089  99.421  85.578  1.00 39.01  ? 171 HIS A N     1 
ATOM   296   C  CA    . HIS A 1 179 ? 82.749  98.886  85.793  1.00 41.24  ? 171 HIS A CA    1 
ATOM   297   C  C     . HIS A 1 179 ? 82.886  97.809  86.861  1.00 43.94  ? 171 HIS A C     1 
ATOM   298   O  O     . HIS A 1 179 ? 83.367  96.706  86.583  1.00 50.61  ? 171 HIS A O     1 
ATOM   299   C  CB    . HIS A 1 179 ? 82.163  98.328  84.499  1.00 45.96  ? 171 HIS A CB    1 
ATOM   300   C  CG    . HIS A 1 179 ? 82.172  99.302  83.362  1.00 51.40  ? 171 HIS A CG    1 
ATOM   301   N  ND1   . HIS A 1 179 ? 81.022  99.872  82.862  1.00 56.88  ? 171 HIS A ND1   1 
ATOM   302   C  CD2   . HIS A 1 179 ? 83.191  99.806  82.627  1.00 51.89  ? 171 HIS A CD2   1 
ATOM   303   C  CE1   . HIS A 1 179 ? 81.332  100.686 81.869  1.00 58.01  ? 171 HIS A CE1   1 
ATOM   304   N  NE2   . HIS A 1 179 ? 82.642  100.664 81.706  1.00 54.27  ? 171 HIS A NE2   1 
ATOM   305   N  N     . LEU A 1 180 ? 82.484  98.130  88.086  1.00 41.40  ? 172 LEU A N     1 
ATOM   306   C  CA    . LEU A 1 180 ? 82.682  97.251  89.229  1.00 42.12  ? 172 LEU A CA    1 
ATOM   307   C  C     . LEU A 1 180 ? 81.370  96.544  89.537  1.00 45.45  ? 172 LEU A C     1 
ATOM   308   O  O     . LEU A 1 180 ? 80.412  97.169  90.001  1.00 52.89  ? 172 LEU A O     1 
ATOM   309   C  CB    . LEU A 1 180 ? 83.179  98.045  90.434  1.00 43.75  ? 172 LEU A CB    1 
ATOM   310   C  CG    . LEU A 1 180 ? 84.404  98.920  90.164  1.00 39.73  ? 172 LEU A CG    1 
ATOM   311   C  CD1   . LEU A 1 180 ? 84.849  99.628  91.427  1.00 34.94  ? 172 LEU A CD1   1 
ATOM   312   C  CD2   . LEU A 1 180 ? 85.536  98.090  89.588  1.00 41.88  ? 172 LEU A CD2   1 
ATOM   313   N  N     . ILE A 1 181 ? 81.326  95.242  89.268  1.00 45.70  ? 173 ILE A N     1 
ATOM   314   C  CA    . ILE A 1 181 ? 80.191  94.410  89.660  1.00 52.04  ? 173 ILE A CA    1 
ATOM   315   C  C     . ILE A 1 181 ? 80.445  93.995  91.105  1.00 58.26  ? 173 ILE A C     1 
ATOM   316   O  O     . ILE A 1 181 ? 81.300  93.150  91.378  1.00 61.37  ? 173 ILE A O     1 
ATOM   317   C  CB    . ILE A 1 181 ? 80.015  93.199  88.740  1.00 54.36  ? 173 ILE A CB    1 
ATOM   318   C  CG1   . ILE A 1 181 ? 79.600  93.638  87.333  1.00 55.10  ? 173 ILE A CG1   1 
ATOM   319   C  CG2   . ILE A 1 181 ? 78.984  92.241  89.313  1.00 61.41  ? 173 ILE A CG2   1 
ATOM   320   C  CD1   . ILE A 1 181 ? 80.755  94.007  86.423  1.00 54.65  ? 173 ILE A CD1   1 
ATOM   321   N  N     . ALA A 1 182 ? 79.722  94.607  92.041  1.00 59.96  ? 174 ALA A N     1 
ATOM   322   C  CA    . ALA A 1 182 ? 80.013  94.418  93.453  1.00 64.83  ? 174 ALA A CA    1 
ATOM   323   C  C     . ALA A 1 182 ? 78.724  94.338  94.255  1.00 72.28  ? 174 ALA A C     1 
ATOM   324   O  O     . ALA A 1 182 ? 77.710  94.942  93.897  1.00 75.52  ? 174 ALA A O     1 
ATOM   325   C  CB    . ALA A 1 182 ? 80.892  95.551  93.999  1.00 60.73  ? 174 ALA A CB    1 
ATOM   326   N  N     . ASP A 1 183 ? 78.779  93.583  95.348  1.00 72.46  ? 175 ASP A N     1 
ATOM   327   C  CA    . ASP A 1 183 ? 77.700  93.576  96.318  1.00 77.50  ? 175 ASP A CA    1 
ATOM   328   C  C     . ASP A 1 183 ? 77.800  94.811  97.209  1.00 76.42  ? 175 ASP A C     1 
ATOM   329   O  O     . ASP A 1 183 ? 78.759  95.582  97.138  1.00 75.56  ? 175 ASP A O     1 
ATOM   330   C  CB    . ASP A 1 183 ? 77.738  92.300  97.156  1.00 81.74  ? 175 ASP A CB    1 
ATOM   331   C  CG    . ASP A 1 183 ? 79.015  92.170  97.959  1.00 79.97  ? 175 ASP A CG    1 
ATOM   332   O  OD1   . ASP A 1 183 ? 80.045  92.731  97.531  1.00 78.22  ? 175 ASP A OD1   1 
ATOM   333   O  OD2   . ASP A 1 183 ? 78.991  91.506  99.016  1.00 82.33  ? 175 ASP A OD2   1 
ATOM   334   N  N     . SER A 1 184 ? 76.796  94.983  98.072  1.00 77.43  ? 176 SER A N     1 
ATOM   335   C  CA    . SER A 1 184 ? 76.718  96.194  98.886  1.00 74.43  ? 176 SER A CA    1 
ATOM   336   C  C     . SER A 1 184 ? 77.940  96.345  99.783  1.00 70.26  ? 176 SER A C     1 
ATOM   337   O  O     . SER A 1 184 ? 78.464  97.454  99.947  1.00 67.24  ? 176 SER A O     1 
ATOM   338   C  CB    . SER A 1 184 ? 75.438  96.179  99.720  1.00 81.72  ? 176 SER A CB    1 
ATOM   339   O  OG    . SER A 1 184 ? 75.376  95.023  100.536 1.00 88.61  ? 176 SER A OG    1 
ATOM   340   N  N     . ILE A 1 185 ? 78.408  95.239  100.367 1.00 70.55  ? 177 ILE A N     1 
ATOM   341   C  CA    . ILE A 1 185 ? 79.564  95.287  101.261 1.00 69.88  ? 177 ILE A CA    1 
ATOM   342   C  C     . ILE A 1 185 ? 80.771  95.872  100.538 1.00 64.90  ? 177 ILE A C     1 
ATOM   343   O  O     . ILE A 1 185 ? 81.439  96.783  101.041 1.00 62.38  ? 177 ILE A O     1 
ATOM   344   C  CB    . ILE A 1 185 ? 79.868  93.885  101.818 1.00 69.58  ? 177 ILE A CB    1 
ATOM   345   C  CG1   . ILE A 1 185 ? 78.786  93.455  102.808 1.00 71.26  ? 177 ILE A CG1   1 
ATOM   346   C  CG2   . ILE A 1 185 ? 81.241  93.854  102.464 1.00 63.66  ? 177 ILE A CG2   1 
ATOM   347   C  CD1   . ILE A 1 185 ? 79.038  92.101  103.434 1.00 66.54  ? 177 ILE A CD1   1 
ATOM   348   N  N     . ALA A 1 186 ? 81.067  95.358  99.345  1.00 66.02  ? 178 ALA A N     1 
ATOM   349   C  CA    . ALA A 1 186 ? 82.169  95.901  98.563  1.00 61.39  ? 178 ALA A CA    1 
ATOM   350   C  C     . ALA A 1 186 ? 81.807  97.228  97.913  1.00 58.93  ? 178 ALA A C     1 
ATOM   351   O  O     . ALA A 1 186 ? 82.687  98.075  97.716  1.00 53.05  ? 178 ALA A O     1 
ATOM   352   C  CB    . ALA A 1 186 ? 82.602  94.896  97.496  1.00 58.44  ? 178 ALA A CB    1 
ATOM   353   N  N     . GLU A 1 187 ? 80.531  97.421  97.565  1.00 65.28  ? 179 GLU A N     1 
ATOM   354   C  CA    . GLU A 1 187 ? 80.126  98.645  96.883  1.00 61.69  ? 179 GLU A CA    1 
ATOM   355   C  C     . GLU A 1 187 ? 80.349  99.868  97.759  1.00 55.99  ? 179 GLU A C     1 
ATOM   356   O  O     . GLU A 1 187 ? 80.858  100.887 97.285  1.00 51.78  ? 179 GLU A O     1 
ATOM   357   C  CB    . GLU A 1 187 ? 78.661  98.561  96.458  1.00 66.35  ? 179 GLU A CB    1 
ATOM   358   C  CG    . GLU A 1 187 ? 78.147  99.814  95.775  1.00 69.47  ? 179 GLU A CG    1 
ATOM   359   C  CD    . GLU A 1 187 ? 76.708  99.681  95.325  1.00 82.78  ? 179 GLU A CD    1 
ATOM   360   O  OE1   . GLU A 1 187 ? 76.144  98.575  95.457  1.00 88.31  ? 179 GLU A OE1   1 
ATOM   361   O  OE2   . GLU A 1 187 ? 76.141  100.682 94.840  1.00 88.50  ? 179 GLU A OE2   1 
ATOM   362   N  N     . GLN A 1 188 ? 79.973  99.790  99.037  1.00 59.92  ? 180 GLN A N     1 
ATOM   363   C  CA    . GLN A 1 188 ? 80.165  100.928 99.932  1.00 58.42  ? 180 GLN A CA    1 
ATOM   364   C  C     . GLN A 1 188 ? 81.643  101.276 100.064 1.00 53.67  ? 180 GLN A C     1 
ATOM   365   O  O     . GLN A 1 188 ? 82.036  102.446 99.949  1.00 53.01  ? 180 GLN A O     1 
ATOM   366   C  CB    . GLN A 1 188 ? 79.561  100.621 101.301 1.00 54.68  ? 180 GLN A CB    1 
ATOM   367   C  CG    . GLN A 1 188 ? 79.827  101.688 102.348 1.00 55.01  ? 180 GLN A CG    1 
ATOM   368   C  CD    . GLN A 1 188 ? 79.342  101.286 103.724 1.00 63.81  ? 180 GLN A CD    1 
ATOM   369   O  OE1   . GLN A 1 188 ? 78.820  100.187 103.914 1.00 66.92  ? 180 GLN A OE1   1 
ATOM   370   N  NE2   . GLN A 1 188 ? 79.512  102.175 104.695 1.00 64.22  ? 180 GLN A NE2   1 
ATOM   371   N  N     . ILE A 1 189 ? 82.478  100.259 100.285 1.00 49.63  ? 181 ILE A N     1 
ATOM   372   C  CA    . ILE A 1 189 ? 83.909  100.482 100.467 1.00 44.48  ? 181 ILE A CA    1 
ATOM   373   C  C     . ILE A 1 189 ? 84.509  101.115 99.221  1.00 46.87  ? 181 ILE A C     1 
ATOM   374   O  O     . ILE A 1 189 ? 85.225  102.120 99.298  1.00 45.44  ? 181 ILE A O     1 
ATOM   375   C  CB    . ILE A 1 189 ? 84.615  99.160  100.812 1.00 42.79  ? 181 ILE A CB    1 
ATOM   376   C  CG1   . ILE A 1 189 ? 84.021  98.553  102.080 1.00 44.36  ? 181 ILE A CG1   1 
ATOM   377   C  CG2   . ILE A 1 189 ? 86.110  99.381  100.957 1.00 38.58  ? 181 ILE A CG2   1 
ATOM   378   C  CD1   . ILE A 1 189 ? 84.514  97.163  102.359 1.00 42.49  ? 181 ILE A CD1   1 
ATOM   379   N  N     . LEU A 1 190 ? 84.220  100.538 98.053  1.00 48.35  ? 182 LEU A N     1 
ATOM   380   C  CA    . LEU A 1 190 ? 84.823  101.033 96.822  1.00 43.23  ? 182 LEU A CA    1 
ATOM   381   C  C     . LEU A 1 190 ? 84.298  102.415 96.461  1.00 45.51  ? 182 LEU A C     1 
ATOM   382   O  O     . LEU A 1 190 ? 85.058  103.262 95.979  1.00 47.61  ? 182 LEU A O     1 
ATOM   383   C  CB    . LEU A 1 190 ? 84.581  100.042 95.687  1.00 41.73  ? 182 LEU A CB    1 
ATOM   384   C  CG    . LEU A 1 190 ? 85.332  98.721  95.849  1.00 40.00  ? 182 LEU A CG    1 
ATOM   385   C  CD1   . LEU A 1 190 ? 85.078  97.798  94.671  1.00 44.43  ? 182 LEU A CD1   1 
ATOM   386   C  CD2   . LEU A 1 190 ? 86.817  98.986  96.019  1.00 39.21  ? 182 LEU A CD2   1 
ATOM   387   N  N     . ALA A 1 191 ? 83.008  102.668 96.692  1.00 46.22  ? 183 ALA A N     1 
ATOM   388   C  CA    . ALA A 1 191 ? 82.451  103.982 96.407  1.00 44.34  ? 183 ALA A CA    1 
ATOM   389   C  C     . ALA A 1 191 ? 83.111  105.048 97.267  1.00 42.92  ? 183 ALA A C     1 
ATOM   390   O  O     . ALA A 1 191 ? 83.523  106.098 96.762  1.00 48.14  ? 183 ALA A O     1 
ATOM   391   C  CB    . ALA A 1 191 ? 80.939  103.967 96.627  1.00 46.84  ? 183 ALA A CB    1 
ATOM   392   N  N     . THR A 1 192 ? 83.241  104.787 98.571  1.00 42.81  ? 184 THR A N     1 
ATOM   393   C  CA    . THR A 1 192 ? 83.906  105.753 99.440  1.00 45.47  ? 184 THR A CA    1 
ATOM   394   C  C     . THR A 1 192 ? 85.366  105.936 99.043  1.00 44.35  ? 184 THR A C     1 
ATOM   395   O  O     . THR A 1 192 ? 85.875  107.065 99.013  1.00 44.05  ? 184 THR A O     1 
ATOM   396   C  CB    . THR A 1 192 ? 83.798  105.308 100.897 1.00 42.29  ? 184 THR A CB    1 
ATOM   397   O  OG1   . THR A 1 192 ? 82.420  105.099 101.231 1.00 44.67  ? 184 THR A OG1   1 
ATOM   398   C  CG2   . THR A 1 192 ? 84.383  106.365 101.820 1.00 38.48  ? 184 THR A CG2   1 
ATOM   399   N  N     . LEU A 1 193 ? 86.049  104.835 98.717  1.00 41.85  ? 185 LEU A N     1 
ATOM   400   C  CA    . LEU A 1 193 ? 87.463  104.905 98.368  1.00 38.36  ? 185 LEU A CA    1 
ATOM   401   C  C     . LEU A 1 193 ? 87.684  105.741 97.117  1.00 44.54  ? 185 LEU A C     1 
ATOM   402   O  O     . LEU A 1 193 ? 88.582  106.587 97.074  1.00 46.79  ? 185 LEU A O     1 
ATOM   403   C  CB    . LEU A 1 193 ? 88.018  103.497 98.170  1.00 35.53  ? 185 LEU A CB    1 
ATOM   404   C  CG    . LEU A 1 193 ? 89.362  103.432 97.445  1.00 36.67  ? 185 LEU A CG    1 
ATOM   405   C  CD1   . LEU A 1 193 ? 90.522  103.556 98.418  1.00 35.62  ? 185 LEU A CD1   1 
ATOM   406   C  CD2   . LEU A 1 193 ? 89.457  102.160 96.633  1.00 43.73  ? 185 LEU A CD2   1 
ATOM   407   N  N     . PHE A 1 194 ? 86.873  105.520 96.082  1.00 48.79  ? 186 PHE A N     1 
ATOM   408   C  CA    . PHE A 1 194 ? 87.047  106.270 94.846  1.00 42.57  ? 186 PHE A CA    1 
ATOM   409   C  C     . PHE A 1 194 ? 86.549  107.702 94.970  1.00 45.28  ? 186 PHE A C     1 
ATOM   410   O  O     . PHE A 1 194 ? 87.082  108.593 94.302  1.00 50.53  ? 186 PHE A O     1 
ATOM   411   C  CB    . PHE A 1 194 ? 86.349  105.556 93.690  1.00 41.57  ? 186 PHE A CB    1 
ATOM   412   C  CG    . PHE A 1 194 ? 87.070  104.328 93.221  1.00 46.53  ? 186 PHE A CG    1 
ATOM   413   C  CD1   . PHE A 1 194 ? 88.352  104.419 92.710  1.00 49.50  ? 186 PHE A CD1   1 
ATOM   414   C  CD2   . PHE A 1 194 ? 86.469  103.085 93.286  1.00 48.53  ? 186 PHE A CD2   1 
ATOM   415   C  CE1   . PHE A 1 194 ? 89.021  103.295 92.279  1.00 48.68  ? 186 PHE A CE1   1 
ATOM   416   C  CE2   . PHE A 1 194 ? 87.134  101.956 92.856  1.00 47.46  ? 186 PHE A CE2   1 
ATOM   417   C  CZ    . PHE A 1 194 ? 88.411  102.062 92.351  1.00 47.55  ? 186 PHE A CZ    1 
ATOM   418   N  N     . GLN A 1 195 ? 85.540  107.947 95.809  1.00 45.40  ? 187 GLN A N     1 
ATOM   419   C  CA    . GLN A 1 195 ? 85.116  109.317 96.063  1.00 51.58  ? 187 GLN A CA    1 
ATOM   420   C  C     . GLN A 1 195 ? 86.220  110.114 96.743  1.00 50.84  ? 187 GLN A C     1 
ATOM   421   O  O     . GLN A 1 195 ? 86.473  111.270 96.385  1.00 58.35  ? 187 GLN A O     1 
ATOM   422   C  CB    . GLN A 1 195 ? 83.849  109.318 96.916  1.00 55.97  ? 187 GLN A CB    1 
ATOM   423   C  CG    . GLN A 1 195 ? 83.396  110.695 97.357  1.00 66.37  ? 187 GLN A CG    1 
ATOM   424   C  CD    . GLN A 1 195 ? 82.207  110.639 98.294  1.00 81.52  ? 187 GLN A CD    1 
ATOM   425   O  OE1   . GLN A 1 195 ? 81.758  109.561 98.681  1.00 82.56  ? 187 GLN A OE1   1 
ATOM   426   N  NE2   . GLN A 1 195 ? 81.689  111.805 98.663  1.00 86.12  ? 187 GLN A NE2   1 
ATOM   427   N  N     . THR A 1 196 ? 86.894  109.511 97.723  1.00 48.25  ? 188 THR A N     1 
ATOM   428   C  CA    . THR A 1 196 ? 87.962  110.207 98.429  1.00 48.86  ? 188 THR A CA    1 
ATOM   429   C  C     . THR A 1 196 ? 89.287  110.189 97.677  1.00 48.86  ? 188 THR A C     1 
ATOM   430   O  O     . THR A 1 196 ? 90.169  110.997 97.985  1.00 51.35  ? 188 THR A O     1 
ATOM   431   C  CB    . THR A 1 196 ? 88.152  109.592 99.815  1.00 44.56  ? 188 THR A CB    1 
ATOM   432   O  OG1   . THR A 1 196 ? 88.360  108.181 99.685  1.00 45.07  ? 188 THR A OG1   1 
ATOM   433   C  CG2   . THR A 1 196 ? 86.926  109.835 100.673 1.00 45.51  ? 188 THR A CG2   1 
ATOM   434   N  N     . TRP A 1 197 ? 89.448  109.294 96.701  1.00 48.55  ? 189 TRP A N     1 
ATOM   435   C  CA    . TRP A 1 197 ? 90.726  109.154 96.012  1.00 50.12  ? 189 TRP A CA    1 
ATOM   436   C  C     . TRP A 1 197 ? 90.970  110.295 95.032  1.00 55.94  ? 189 TRP A C     1 
ATOM   437   O  O     . TRP A 1 197 ? 92.087  110.817 94.954  1.00 57.57  ? 189 TRP A O     1 
ATOM   438   C  CB    . TRP A 1 197 ? 90.780  107.805 95.295  1.00 47.59  ? 189 TRP A CB    1 
ATOM   439   C  CG    . TRP A 1 197 ? 92.165  107.287 95.077  1.00 45.64  ? 189 TRP A CG    1 
ATOM   440   C  CD1   . TRP A 1 197 ? 93.328  107.992 95.160  1.00 48.19  ? 189 TRP A CD1   1 
ATOM   441   C  CD2   . TRP A 1 197 ? 92.533  105.943 94.749  1.00 43.01  ? 189 TRP A CD2   1 
ATOM   442   N  NE1   . TRP A 1 197 ? 94.397  107.172 94.898  1.00 48.90  ? 189 TRP A NE1   1 
ATOM   443   C  CE2   . TRP A 1 197 ? 93.935  105.909 94.643  1.00 44.78  ? 189 TRP A CE2   1 
ATOM   444   C  CE3   . TRP A 1 197 ? 91.811  104.767 94.533  1.00 42.27  ? 189 TRP A CE3   1 
ATOM   445   C  CZ2   . TRP A 1 197 ? 94.630  104.745 94.331  1.00 42.64  ? 189 TRP A CZ2   1 
ATOM   446   C  CZ3   . TRP A 1 197 ? 92.503  103.613 94.223  1.00 41.38  ? 189 TRP A CZ3   1 
ATOM   447   C  CH2   . TRP A 1 197 ? 93.898  103.610 94.125  1.00 40.40  ? 189 TRP A CH2   1 
ATOM   448   N  N     . MET A 1 198 ? 89.941  110.684 94.276  1.00 55.76  ? 190 MET A N     1 
ATOM   449   C  CA    . MET A 1 198 ? 90.014  111.809 93.342  1.00 57.05  ? 190 MET A CA    1 
ATOM   450   C  C     . MET A 1 198 ? 91.083  111.587 92.272  1.00 57.79  ? 190 MET A C     1 
ATOM   451   O  O     . MET A 1 198 ? 91.938  112.440 92.029  1.00 60.28  ? 190 MET A O     1 
ATOM   452   C  CB    . MET A 1 198 ? 90.256  113.124 94.085  1.00 57.45  ? 190 MET A CB    1 
ATOM   453   C  CG    . MET A 1 198 ? 89.138  113.533 95.018  1.00 61.28  ? 190 MET A CG    1 
ATOM   454   S  SD    . MET A 1 198 ? 89.536  115.056 95.892  1.00 87.95  ? 190 MET A SD    1 
ATOM   455   C  CE    . MET A 1 198 ? 87.962  115.420 96.657  1.00 86.93  ? 190 MET A CE    1 
ATOM   456   N  N     . VAL A 1 199 ? 91.029  110.428 91.625  1.00 57.49  ? 191 VAL A N     1 
ATOM   457   C  CA    . VAL A 1 199 ? 91.961  110.122 90.543  1.00 65.68  ? 191 VAL A CA    1 
ATOM   458   C  C     . VAL A 1 199 ? 91.459  110.773 89.259  1.00 70.34  ? 191 VAL A C     1 
ATOM   459   O  O     . VAL A 1 199 ? 90.330  110.499 88.827  1.00 66.37  ? 191 VAL A O     1 
ATOM   460   C  CB    . VAL A 1 199 ? 92.139  108.608 90.360  1.00 62.17  ? 191 VAL A CB    1 
ATOM   461   C  CG1   . VAL A 1 199 ? 93.244  108.330 89.358  1.00 63.18  ? 191 VAL A CG1   1 
ATOM   462   C  CG2   . VAL A 1 199 ? 92.447  107.949 91.688  1.00 59.91  ? 191 VAL A CG2   1 
ATOM   463   N  N     . PRO A 1 200 ? 92.250  111.634 88.624  1.00 71.86  ? 192 PRO A N     1 
ATOM   464   C  CA    . PRO A 1 200 ? 91.803  112.267 87.380  1.00 62.88  ? 192 PRO A CA    1 
ATOM   465   C  C     . PRO A 1 200 ? 91.632  111.256 86.259  1.00 63.97  ? 192 PRO A C     1 
ATOM   466   O  O     . PRO A 1 200 ? 92.311  110.228 86.207  1.00 69.27  ? 192 PRO A O     1 
ATOM   467   C  CB    . PRO A 1 200 ? 92.928  113.258 87.060  1.00 71.11  ? 192 PRO A CB    1 
ATOM   468   C  CG    . PRO A 1 200 ? 93.640  113.468 88.356  1.00 72.52  ? 192 PRO A CG    1 
ATOM   469   C  CD    . PRO A 1 200 ? 93.546  112.162 89.077  1.00 73.81  ? 192 PRO A CD    1 
ATOM   470   N  N     . ALA A 1 201 ? 90.702  111.569 85.355  1.00 66.83  ? 193 ALA A N     1 
ATOM   471   C  CA    . ALA A 1 201 ? 90.452  110.776 84.150  1.00 64.91  ? 193 ALA A CA    1 
ATOM   472   C  C     . ALA A 1 201 ? 90.097  109.329 84.475  1.00 61.31  ? 193 ALA A C     1 
ATOM   473   O  O     . ALA A 1 201 ? 90.423  108.413 83.717  1.00 63.92  ? 193 ALA A O     1 
ATOM   474   C  CB    . ALA A 1 201 ? 91.646  110.828 83.192  1.00 70.04  ? 193 ALA A CB    1 
ATOM   475   N  N     . VAL A 1 202 ? 89.427  109.109 85.602  1.00 59.31  ? 194 VAL A N     1 
ATOM   476   C  CA    . VAL A 1 202 ? 88.953  107.787 85.990  1.00 57.65  ? 194 VAL A CA    1 
ATOM   477   C  C     . VAL A 1 202 ? 87.475  107.902 86.321  1.00 53.72  ? 194 VAL A C     1 
ATOM   478   O  O     . VAL A 1 202 ? 87.096  108.647 87.233  1.00 55.26  ? 194 VAL A O     1 
ATOM   479   C  CB    . VAL A 1 202 ? 89.732  107.216 87.186  1.00 62.05  ? 194 VAL A CB    1 
ATOM   480   C  CG1   . VAL A 1 202 ? 89.045  105.970 87.716  1.00 58.43  ? 194 VAL A CG1   1 
ATOM   481   C  CG2   . VAL A 1 202 ? 91.156  106.898 86.780  1.00 63.13  ? 194 VAL A CG2   1 
ATOM   482   N  N     . ARG A 1 203 ? 86.643  107.173 85.586  1.00 51.59  ? 195 ARG A N     1 
ATOM   483   C  CA    . ARG A 1 203 ? 85.203  107.171 85.804  1.00 49.94  ? 195 ARG A CA    1 
ATOM   484   C  C     . ARG A 1 203 ? 84.792  105.792 86.297  1.00 49.49  ? 195 ARG A C     1 
ATOM   485   O  O     . ARG A 1 203 ? 84.994  104.798 85.596  1.00 57.02  ? 195 ARG A O     1 
ATOM   486   C  CB    . ARG A 1 203 ? 84.456  107.535 84.521  1.00 50.66  ? 195 ARG A CB    1 
ATOM   487   C  CG    . ARG A 1 203 ? 82.948  107.580 84.672  1.00 54.31  ? 195 ARG A CG    1 
ATOM   488   C  CD    . ARG A 1 203 ? 82.284  108.005 83.376  1.00 65.01  ? 195 ARG A CD    1 
ATOM   489   N  NE    . ARG A 1 203 ? 80.830  108.006 83.483  1.00 66.24  ? 195 ARG A NE    1 
ATOM   490   C  CZ    . ARG A 1 203 ? 80.007  108.301 82.486  1.00 71.52  ? 195 ARG A CZ    1 
ATOM   491   N  NH1   . ARG A 1 203 ? 80.463  108.626 81.287  1.00 70.83  ? 195 ARG A NH1   1 
ATOM   492   N  NH2   . ARG A 1 203 ? 78.695  108.268 82.697  1.00 78.04  ? 195 ARG A NH2   1 
ATOM   493   N  N     . VAL A 1 204 ? 84.202  105.733 87.486  1.00 48.10  ? 196 VAL A N     1 
ATOM   494   C  CA    . VAL A 1 204 ? 83.881  104.473 88.144  1.00 44.53  ? 196 VAL A CA    1 
ATOM   495   C  C     . VAL A 1 204 ? 82.370  104.340 88.242  1.00 47.87  ? 196 VAL A C     1 
ATOM   496   O  O     . VAL A 1 204 ? 81.690  105.263 88.704  1.00 55.46  ? 196 VAL A O     1 
ATOM   497   C  CB    . VAL A 1 204 ? 84.524  104.383 89.539  1.00 47.52  ? 196 VAL A CB    1 
ATOM   498   C  CG1   . VAL A 1 204 ? 84.244  103.027 90.161  1.00 49.01  ? 196 VAL A CG1   1 
ATOM   499   C  CG2   . VAL A 1 204 ? 86.018  104.638 89.453  1.00 50.59  ? 196 VAL A CG2   1 
ATOM   500   N  N     . ASP A 1 205 ? 81.850  103.195 87.810  1.00 45.87  ? 197 ASP A N     1 
ATOM   501   C  CA    . ASP A 1 205 ? 80.435  102.882 87.932  1.00 47.22  ? 197 ASP A CA    1 
ATOM   502   C  C     . ASP A 1 205 ? 80.285  101.538 88.626  1.00 47.91  ? 197 ASP A C     1 
ATOM   503   O  O     . ASP A 1 205 ? 81.162  100.675 88.532  1.00 51.98  ? 197 ASP A O     1 
ATOM   504   C  CB    . ASP A 1 205 ? 79.739  102.853 86.566  1.00 49.92  ? 197 ASP A CB    1 
ATOM   505   C  CG    . ASP A 1 205 ? 79.716  104.213 85.896  1.00 56.70  ? 197 ASP A CG    1 
ATOM   506   O  OD1   . ASP A 1 205 ? 79.693  105.233 86.616  1.00 53.68  ? 197 ASP A OD1   1 
ATOM   507   O  OD2   . ASP A 1 205 ? 79.720  104.263 84.649  1.00 65.05  ? 197 ASP A OD2   1 
ATOM   508   N  N     . PHE A 1 206 ? 79.169  101.370 89.328  1.00 47.91  ? 198 PHE A N     1 
ATOM   509   C  CA    . PHE A 1 206 ? 78.931  100.198 90.154  1.00 48.44  ? 198 PHE A CA    1 
ATOM   510   C  C     . PHE A 1 206 ? 77.675  99.473  89.697  1.00 49.59  ? 198 PHE A C     1 
ATOM   511   O  O     . PHE A 1 206 ? 76.714  100.091 89.232  1.00 52.35  ? 198 PHE A O     1 
ATOM   512   C  CB    . PHE A 1 206 ? 78.803  100.583 91.631  1.00 49.94  ? 198 PHE A CB    1 
ATOM   513   C  CG    . PHE A 1 206 ? 80.044  101.203 92.200  1.00 50.36  ? 198 PHE A CG    1 
ATOM   514   C  CD1   . PHE A 1 206 ? 80.280  102.560 92.069  1.00 49.48  ? 198 PHE A CD1   1 
ATOM   515   C  CD2   . PHE A 1 206 ? 80.979  100.428 92.860  1.00 49.67  ? 198 PHE A CD2   1 
ATOM   516   C  CE1   . PHE A 1 206 ? 81.422  103.130 92.586  1.00 49.19  ? 198 PHE A CE1   1 
ATOM   517   C  CE2   . PHE A 1 206 ? 82.121  100.994 93.378  1.00 47.80  ? 198 PHE A CE2   1 
ATOM   518   C  CZ    . PHE A 1 206 ? 82.343  102.346 93.241  1.00 46.96  ? 198 PHE A CZ    1 
ATOM   519   N  N     . TYR A 1 207 ? 77.696  98.150  89.831  1.00 50.98  ? 199 TYR A N     1 
ATOM   520   C  CA    . TYR A 1 207 ? 76.589  97.303  89.416  1.00 57.70  ? 199 TYR A CA    1 
ATOM   521   C  C     . TYR A 1 207 ? 76.270  96.301  90.514  1.00 66.91  ? 199 TYR A C     1 
ATOM   522   O  O     . TYR A 1 207 ? 77.172  95.690  91.097  1.00 70.89  ? 199 TYR A O     1 
ATOM   523   C  CB    . TYR A 1 207 ? 76.911  96.577  88.105  1.00 57.78  ? 199 TYR A CB    1 
ATOM   524   C  CG    . TYR A 1 207 ? 77.220  97.519  86.965  1.00 54.86  ? 199 TYR A CG    1 
ATOM   525   C  CD1   . TYR A 1 207 ? 78.514  97.963  86.738  1.00 55.57  ? 199 TYR A CD1   1 
ATOM   526   C  CD2   . TYR A 1 207 ? 76.216  97.974  86.124  1.00 52.91  ? 199 TYR A CD2   1 
ATOM   527   C  CE1   . TYR A 1 207 ? 78.801  98.829  85.704  1.00 52.43  ? 199 TYR A CE1   1 
ATOM   528   C  CE2   . TYR A 1 207 ? 76.494  98.840  85.086  1.00 56.97  ? 199 TYR A CE2   1 
ATOM   529   C  CZ    . TYR A 1 207 ? 77.788  99.264  84.882  1.00 55.55  ? 199 TYR A CZ    1 
ATOM   530   O  OH    . TYR A 1 207 ? 78.073  100.126 83.850  1.00 59.51  ? 199 TYR A OH    1 
ATOM   531   N  N     . ASN A 1 208 ? 74.978  96.136  90.789  1.00 71.47  ? 200 ASN A N     1 
ATOM   532   C  CA    . ASN A 1 208 ? 74.523  95.247  91.852  1.00 81.26  ? 200 ASN A CA    1 
ATOM   533   C  C     . ASN A 1 208 ? 74.840  93.805  91.477  1.00 84.85  ? 200 ASN A C     1 
ATOM   534   O  O     . ASN A 1 208 ? 74.264  93.259  90.531  1.00 89.68  ? 200 ASN A O     1 
ATOM   535   C  CB    . ASN A 1 208 ? 73.028  95.437  92.087  1.00 86.73  ? 200 ASN A CB    1 
ATOM   536   C  CG    . ASN A 1 208 ? 72.545  94.777  93.366  1.00 96.21  ? 200 ASN A CG    1 
ATOM   537   O  OD1   . ASN A 1 208 ? 73.114  93.788  93.826  1.00 98.33  ? 200 ASN A OD1   1 
ATOM   538   N  ND2   . ASN A 1 208 ? 71.484  95.325  93.947  1.00 100.17 ? 200 ASN A ND2   1 
ATOM   539   N  N     . ALA A 1 209 ? 75.757  93.186  92.221  1.00 83.34  ? 201 ALA A N     1 
ATOM   540   C  CA    . ALA A 1 209 ? 76.102  91.793  91.964  1.00 87.12  ? 201 ALA A CA    1 
ATOM   541   C  C     . ALA A 1 209 ? 75.022  90.840  92.456  1.00 100.94 ? 201 ALA A C     1 
ATOM   542   O  O     . ALA A 1 209 ? 74.868  89.747  91.901  1.00 105.86 ? 201 ALA A O     1 
ATOM   543   C  CB    . ALA A 1 209 ? 77.442  91.454  92.618  1.00 81.20  ? 201 ALA A CB    1 
ATOM   544   N  N     . ASP A 1 210 ? 74.273  91.230  93.490  1.00 101.09 ? 202 ASP A N     1 
ATOM   545   C  CA    . ASP A 1 210 ? 73.251  90.345  94.041  1.00 104.79 ? 202 ASP A CA    1 
ATOM   546   C  C     . ASP A 1 210 ? 72.156  90.059  93.020  1.00 109.65 ? 202 ASP A C     1 
ATOM   547   O  O     . ASP A 1 210 ? 71.658  88.930  92.934  1.00 115.27 ? 202 ASP A O     1 
ATOM   548   C  CB    . ASP A 1 210 ? 72.657  90.955  95.310  1.00 107.32 ? 202 ASP A CB    1 
ATOM   549   C  CG    . ASP A 1 210 ? 73.714  91.288  96.345  1.00 109.28 ? 202 ASP A CG    1 
ATOM   550   O  OD1   . ASP A 1 210 ? 74.780  90.637  96.339  1.00 106.68 ? 202 ASP A OD1   1 
ATOM   551   O  OD2   . ASP A 1 210 ? 73.480  92.202  97.164  1.00 107.22 ? 202 ASP A OD2   1 
ATOM   552   N  N     . GLU A 1 211 ? 71.772  91.069  92.234  1.00 107.56 ? 203 GLU A N     1 
ATOM   553   C  CA    . GLU A 1 211 ? 70.731  90.877  91.229  1.00 109.90 ? 203 GLU A CA    1 
ATOM   554   C  C     . GLU A 1 211 ? 71.128  89.826  90.200  1.00 112.13 ? 203 GLU A C     1 
ATOM   555   O  O     . GLU A 1 211 ? 70.257  89.196  89.590  1.00 114.98 ? 203 GLU A O     1 
ATOM   556   C  CB    . GLU A 1 211 ? 70.422  92.203  90.535  1.00 107.24 ? 203 GLU A CB    1 
ATOM   557   C  CG    . GLU A 1 211 ? 69.969  93.306  91.476  1.00 108.23 ? 203 GLU A CG    1 
ATOM   558   C  CD    . GLU A 1 211 ? 69.789  94.636  90.769  1.00 110.70 ? 203 GLU A CD    1 
ATOM   559   O  OE1   . GLU A 1 211 ? 69.977  94.685  89.536  1.00 112.97 ? 203 GLU A OE1   1 
ATOM   560   O  OE2   . GLU A 1 211 ? 69.462  95.632  91.448  1.00 107.84 ? 203 GLU A OE2   1 
ATOM   561   N  N     . LEU A 1 212 ? 72.427  89.623  89.995  1.00 111.12 ? 204 LEU A N     1 
ATOM   562   C  CA    . LEU A 1 212 ? 72.916  88.619  89.061  1.00 110.75 ? 204 LEU A CA    1 
ATOM   563   C  C     . LEU A 1 212 ? 73.007  87.229  89.673  1.00 116.29 ? 204 LEU A C     1 
ATOM   564   O  O     . LEU A 1 212 ? 73.245  86.264  88.939  1.00 123.08 ? 204 LEU A O     1 
ATOM   565   C  CB    . LEU A 1 212 ? 74.291  89.025  88.526  1.00 104.43 ? 204 LEU A CB    1 
ATOM   566   C  CG    . LEU A 1 212 ? 74.389  90.440  87.958  1.00 98.14  ? 204 LEU A CG    1 
ATOM   567   C  CD1   . LEU A 1 212 ? 75.792  90.710  87.442  1.00 92.77  ? 204 LEU A CD1   1 
ATOM   568   C  CD2   . LEU A 1 212 ? 73.356  90.647  86.863  1.00 98.42  ? 204 LEU A CD2   1 
ATOM   569   N  N     . LYS A 1 213 ? 72.822  87.102  90.991  1.00 115.82 ? 205 LYS A N     1 
ATOM   570   C  CA    . LYS A 1 213 ? 72.953  85.798  91.632  1.00 121.47 ? 205 LYS A CA    1 
ATOM   571   C  C     . LYS A 1 213 ? 71.935  84.807  91.082  1.00 130.24 ? 205 LYS A C     1 
ATOM   572   O  O     . LYS A 1 213 ? 72.273  83.650  90.803  1.00 134.20 ? 205 LYS A O     1 
ATOM   573   C  CB    . LYS A 1 213 ? 72.803  85.938  93.147  1.00 118.64 ? 205 LYS A CB    1 
ATOM   574   C  CG    . LYS A 1 213 ? 73.948  86.678  93.816  1.00 116.95 ? 205 LYS A CG    1 
ATOM   575   C  CD    . LYS A 1 213 ? 73.794  86.681  95.328  1.00 115.55 ? 205 LYS A CD    1 
ATOM   576   C  CE    . LYS A 1 213 ? 74.978  87.357  95.999  1.00 111.96 ? 205 LYS A CE    1 
ATOM   577   N  NZ    . LYS A 1 213 ? 74.861  87.345  97.483  1.00 116.31 ? 205 LYS A NZ    1 
ATOM   578   N  N     . SER A 1 214 ? 70.687  85.248  90.902  1.00 131.01 ? 206 SER A N     1 
ATOM   579   C  CA    . SER A 1 214 ? 69.669  84.380  90.322  1.00 134.69 ? 206 SER A CA    1 
ATOM   580   C  C     . SER A 1 214 ? 70.027  83.942  88.909  1.00 132.14 ? 206 SER A C     1 
ATOM   581   O  O     . SER A 1 214 ? 69.506  82.927  88.435  1.00 132.20 ? 206 SER A O     1 
ATOM   582   C  CB    . SER A 1 214 ? 68.313  85.087  90.322  1.00 133.84 ? 206 SER A CB    1 
ATOM   583   O  OG    . SER A 1 214 ? 68.358  86.277  89.555  1.00 130.01 ? 206 SER A OG    1 
ATOM   584   N  N     . GLU A 1 215 ? 70.904  84.682  88.227  1.00 129.87 ? 207 GLU A N     1 
ATOM   585   C  CA    . GLU A 1 215 ? 71.346  84.276  86.900  1.00 127.55 ? 207 GLU A CA    1 
ATOM   586   C  C     . GLU A 1 215 ? 72.289  83.082  86.948  1.00 131.47 ? 207 GLU A C     1 
ATOM   587   O  O     . GLU A 1 215 ? 72.423  82.376  85.943  1.00 135.07 ? 207 GLU A O     1 
ATOM   588   C  CB    . GLU A 1 215 ? 72.027  85.446  86.190  1.00 121.58 ? 207 GLU A CB    1 
ATOM   589   C  CG    . GLU A 1 215 ? 71.211  86.728  86.188  1.00 124.43 ? 207 GLU A CG    1 
ATOM   590   C  CD    . GLU A 1 215 ? 69.898  86.589  85.442  1.00 130.63 ? 207 GLU A CD    1 
ATOM   591   O  OE1   . GLU A 1 215 ? 69.828  85.770  84.502  1.00 132.53 ? 207 GLU A OE1   1 
ATOM   592   O  OE2   . GLU A 1 215 ? 68.935  87.300  85.796  1.00 130.67 ? 207 GLU A OE2   1 
ATOM   593   N  N     . VAL A 1 216 ? 72.946  82.843  88.082  1.00 131.64 ? 208 VAL A N     1 
ATOM   594   C  CA    . VAL A 1 216 ? 73.892  81.740  88.200  1.00 133.52 ? 208 VAL A CA    1 
ATOM   595   C  C     . VAL A 1 216 ? 73.584  80.924  89.448  1.00 138.20 ? 208 VAL A C     1 
ATOM   596   O  O     . VAL A 1 216 ? 74.404  80.112  89.889  1.00 141.62 ? 208 VAL A O     1 
ATOM   597   C  CB    . VAL A 1 216 ? 75.343  82.251  88.223  1.00 128.42 ? 208 VAL A CB    1 
ATOM   598   C  CG1   . VAL A 1 216 ? 75.723  82.830  86.871  1.00 125.84 ? 208 VAL A CG1   1 
ATOM   599   C  CG2   . VAL A 1 216 ? 75.515  83.290  89.315  1.00 124.86 ? 208 VAL A CG2   1 
ATOM   600   N  N     . SER A 1 217 ? 72.399  81.135  90.026  1.00 138.08 ? 209 SER A N     1 
ATOM   601   C  CA    . SER A 1 217 ? 72.013  80.374  91.210  1.00 139.99 ? 209 SER A CA    1 
ATOM   602   C  C     . SER A 1 217 ? 71.805  78.900  90.889  1.00 146.05 ? 209 SER A C     1 
ATOM   603   O  O     . SER A 1 217 ? 71.875  78.055  91.788  1.00 146.24 ? 209 SER A O     1 
ATOM   604   C  CB    . SER A 1 217 ? 70.745  80.965  91.826  1.00 136.34 ? 209 SER A CB    1 
ATOM   605   O  OG    . SER A 1 217 ? 69.667  80.930  90.907  1.00 135.37 ? 209 SER A OG    1 
ATOM   606   N  N     . TRP A 1 218 ? 71.547  78.573  89.623  1.00 147.63 ? 210 TRP A N     1 
ATOM   607   C  CA    . TRP A 1 218 ? 71.320  77.194  89.213  1.00 148.28 ? 210 TRP A CA    1 
ATOM   608   C  C     . TRP A 1 218 ? 72.609  76.432  88.933  1.00 147.84 ? 210 TRP A C     1 
ATOM   609   O  O     . TRP A 1 218 ? 72.548  75.229  88.659  1.00 148.55 ? 210 TRP A O     1 
ATOM   610   C  CB    . TRP A 1 218 ? 70.425  77.161  87.971  1.00 146.31 ? 210 TRP A CB    1 
ATOM   611   C  CG    . TRP A 1 218 ? 70.955  77.975  86.830  1.00 144.58 ? 210 TRP A CG    1 
ATOM   612   C  CD1   . TRP A 1 218 ? 70.814  79.320  86.647  1.00 142.64 ? 210 TRP A CD1   1 
ATOM   613   C  CD2   . TRP A 1 218 ? 71.709  77.495  85.711  1.00 144.83 ? 210 TRP A CD2   1 
ATOM   614   N  NE1   . TRP A 1 218 ? 71.435  79.707  85.485  1.00 141.18 ? 210 TRP A NE1   1 
ATOM   615   C  CE2   . TRP A 1 218 ? 71.992  78.606  84.891  1.00 142.51 ? 210 TRP A CE2   1 
ATOM   616   C  CE3   . TRP A 1 218 ? 72.172  76.235  85.322  1.00 145.57 ? 210 TRP A CE3   1 
ATOM   617   C  CZ2   . TRP A 1 218 ? 72.718  78.494  83.707  1.00 140.83 ? 210 TRP A CZ2   1 
ATOM   618   C  CZ3   . TRP A 1 218 ? 72.893  76.126  84.147  1.00 145.03 ? 210 TRP A CZ3   1 
ATOM   619   C  CH2   . TRP A 1 218 ? 73.158  77.249  83.354  1.00 142.57 ? 210 TRP A CH2   1 
ATOM   620   N  N     . ILE A 1 219 ? 73.763  77.090  88.994  1.00 147.02 ? 211 ILE A N     1 
ATOM   621   C  CA    . ILE A 1 219 ? 75.048  76.462  88.702  1.00 147.86 ? 211 ILE A CA    1 
ATOM   622   C  C     . ILE A 1 219 ? 75.762  76.219  90.030  1.00 152.05 ? 211 ILE A C     1 
ATOM   623   O  O     . ILE A 1 219 ? 76.199  77.190  90.669  1.00 150.67 ? 211 ILE A O     1 
ATOM   624   C  CB    . ILE A 1 219 ? 75.901  77.329  87.769  1.00 143.81 ? 211 ILE A CB    1 
ATOM   625   C  CG1   . ILE A 1 219 ? 75.088  77.766  86.550  1.00 144.06 ? 211 ILE A CG1   1 
ATOM   626   C  CG2   . ILE A 1 219 ? 77.148  76.573  87.335  1.00 140.59 ? 211 ILE A CG2   1 
ATOM   627   C  CD1   . ILE A 1 219 ? 75.847  78.669  85.603  1.00 140.96 ? 211 ILE A CD1   1 
ATOM   628   N  N     . PRO A 1 220 ? 75.894  74.973  90.482  1.00 154.02 ? 212 PRO A N     1 
ATOM   629   C  CA    . PRO A 1 220 ? 76.702  74.710  91.680  1.00 151.48 ? 212 PRO A CA    1 
ATOM   630   C  C     . PRO A 1 220 ? 78.154  75.103  91.453  1.00 147.27 ? 212 PRO A C     1 
ATOM   631   O  O     . PRO A 1 220 ? 78.701  74.929  90.362  1.00 145.80 ? 212 PRO A O     1 
ATOM   632   C  CB    . PRO A 1 220 ? 76.550  73.199  91.887  1.00 152.85 ? 212 PRO A CB    1 
ATOM   633   C  CG    . PRO A 1 220 ? 75.290  72.838  91.166  1.00 152.93 ? 212 PRO A CG    1 
ATOM   634   C  CD    . PRO A 1 220 ? 75.229  73.758  89.985  1.00 151.06 ? 212 PRO A CD    1 
ATOM   635   N  N     . ASN A 1 221 ? 78.780  75.638  92.500  1.00 143.86 ? 213 ASN A N     1 
ATOM   636   C  CA    . ASN A 1 221 ? 80.158  76.098  92.415  1.00 141.12 ? 213 ASN A CA    1 
ATOM   637   C  C     . ASN A 1 221 ? 80.921  75.675  93.660  1.00 139.90 ? 213 ASN A C     1 
ATOM   638   O  O     . ASN A 1 221 ? 80.358  75.626  94.758  1.00 140.22 ? 213 ASN A O     1 
ATOM   639   C  CB    . ASN A 1 221 ? 80.226  77.622  92.248  1.00 136.87 ? 213 ASN A CB    1 
ATOM   640   C  CG    . ASN A 1 221 ? 81.628  78.113  91.949  1.00 134.79 ? 213 ASN A CG    1 
ATOM   641   O  OD1   . ASN A 1 221 ? 82.498  77.339  91.549  1.00 137.38 ? 213 ASN A OD1   1 
ATOM   642   N  ND2   . ASN A 1 221 ? 81.855  79.407  92.139  1.00 130.38 ? 213 ASN A ND2   1 
ATOM   643   N  N     . LYS A 1 222 ? 82.207  75.369  93.481  1.00 138.45 ? 214 LYS A N     1 
ATOM   644   C  CA    . LYS A 1 222 ? 83.083  74.998  94.580  1.00 135.60 ? 214 LYS A CA    1 
ATOM   645   C  C     . LYS A 1 222 ? 84.340  75.851  94.673  1.00 131.53 ? 214 LYS A C     1 
ATOM   646   O  O     . LYS A 1 222 ? 85.111  75.679  95.624  1.00 126.41 ? 214 LYS A O     1 
ATOM   647   C  CB    . LYS A 1 222 ? 83.489  73.519  94.468  1.00 139.21 ? 214 LYS A CB    1 
ATOM   648   C  CG    . LYS A 1 222 ? 82.316  72.553  94.510  1.00 141.22 ? 214 LYS A CG    1 
ATOM   649   C  CD    . LYS A 1 222 ? 82.775  71.113  94.350  1.00 143.80 ? 214 LYS A CD    1 
ATOM   650   C  CE    . LYS A 1 222 ? 81.595  70.154  94.375  1.00 145.92 ? 214 LYS A CE    1 
ATOM   651   N  NZ    . LYS A 1 222 ? 82.026  68.738  94.218  1.00 142.33 ? 214 LYS A NZ    1 
ATOM   652   N  N     . HIS A 1 223 ? 84.571  76.753  93.723  1.00 130.69 ? 215 HIS A N     1 
ATOM   653   C  CA    . HIS A 1 223 ? 85.713  77.652  93.789  1.00 124.12 ? 215 HIS A CA    1 
ATOM   654   C  C     . HIS A 1 223 ? 85.572  78.596  94.978  1.00 126.09 ? 215 HIS A C     1 
ATOM   655   O  O     . HIS A 1 223 ? 84.465  78.984  95.364  1.00 126.91 ? 215 HIS A O     1 
ATOM   656   C  CB    . HIS A 1 223 ? 85.833  78.446  92.488  1.00 118.88 ? 215 HIS A CB    1 
ATOM   657   C  CG    . HIS A 1 223 ? 87.113  79.209  92.354  1.00 112.46 ? 215 HIS A CG    1 
ATOM   658   N  ND1   . HIS A 1 223 ? 87.209  80.557  92.626  1.00 112.97 ? 215 HIS A ND1   1 
ATOM   659   C  CD2   . HIS A 1 223 ? 88.348  78.817  91.960  1.00 109.58 ? 215 HIS A CD2   1 
ATOM   660   C  CE1   . HIS A 1 223 ? 88.448  80.961  92.413  1.00 109.55 ? 215 HIS A CE1   1 
ATOM   661   N  NE2   . HIS A 1 223 ? 89.160  79.925  92.009  1.00 105.49 ? 215 HIS A NE2   1 
ATOM   662   N  N     . TYR A 1 224 ? 86.713  78.965  95.567  1.00 125.47 ? 216 TYR A N     1 
ATOM   663   C  CA    . TYR A 1 224 ? 86.689  79.777  96.779  1.00 122.98 ? 216 TYR A CA    1 
ATOM   664   C  C     . TYR A 1 224 ? 86.101  81.162  96.543  1.00 121.92 ? 216 TYR A C     1 
ATOM   665   O  O     . TYR A 1 224 ? 85.677  81.810  97.505  1.00 122.17 ? 216 TYR A O     1 
ATOM   666   C  CB    . TYR A 1 224 ? 88.096  79.895  97.372  1.00 122.71 ? 216 TYR A CB    1 
ATOM   667   C  CG    . TYR A 1 224 ? 89.051  80.764  96.584  1.00 121.02 ? 216 TYR A CG    1 
ATOM   668   C  CD1   . TYR A 1 224 ? 89.842  80.226  95.578  1.00 122.13 ? 216 TYR A CD1   1 
ATOM   669   C  CD2   . TYR A 1 224 ? 89.177  82.121  96.860  1.00 118.42 ? 216 TYR A CD2   1 
ATOM   670   C  CE1   . TYR A 1 224 ? 90.722  81.016  94.862  1.00 123.05 ? 216 TYR A CE1   1 
ATOM   671   C  CE2   . TYR A 1 224 ? 90.050  82.918  96.148  1.00 119.76 ? 216 TYR A CE2   1 
ATOM   672   C  CZ    . TYR A 1 224 ? 90.820  82.361  95.150  1.00 122.14 ? 216 TYR A CZ    1 
ATOM   673   O  OH    . TYR A 1 224 ? 91.694  83.152  94.440  1.00 117.64 ? 216 TYR A OH    1 
ATOM   674   N  N     . SER A 1 225 ? 86.068  81.631  95.294  1.00 121.53 ? 217 SER A N     1 
ATOM   675   C  CA    . SER A 1 225 ? 85.415  82.898  94.992  1.00 120.20 ? 217 SER A CA    1 
ATOM   676   C  C     . SER A 1 225 ? 83.900  82.818  95.117  1.00 122.55 ? 217 SER A C     1 
ATOM   677   O  O     . SER A 1 225 ? 83.241  83.863  95.123  1.00 125.59 ? 217 SER A O     1 
ATOM   678   C  CB    . SER A 1 225 ? 85.795  83.367  93.587  1.00 114.27 ? 217 SER A CB    1 
ATOM   679   O  OG    . SER A 1 225 ? 85.417  82.413  92.611  1.00 116.10 ? 217 SER A OG    1 
ATOM   680   N  N     . GLY A 1 226 ? 83.336  81.616  95.212  1.00 120.58 ? 218 GLY A N     1 
ATOM   681   C  CA    . GLY A 1 226 ? 81.912  81.470  95.425  1.00 121.66 ? 218 GLY A CA    1 
ATOM   682   C  C     . GLY A 1 226 ? 81.087  81.797  94.190  1.00 123.45 ? 218 GLY A C     1 
ATOM   683   O  O     . GLY A 1 226 ? 81.573  81.817  93.054  1.00 125.89 ? 218 GLY A O     1 
ATOM   684   N  N     . ILE A 1 227 ? 79.803  82.064  94.440  1.00 120.89 ? 219 ILE A N     1 
ATOM   685   C  CA    . ILE A 1 227 ? 78.867  82.363  93.360  1.00 122.69 ? 219 ILE A CA    1 
ATOM   686   C  C     . ILE A 1 227 ? 79.300  83.607  92.596  1.00 119.77 ? 219 ILE A C     1 
ATOM   687   O  O     . ILE A 1 227 ? 79.059  83.719  91.387  1.00 117.15 ? 219 ILE A O     1 
ATOM   688   C  CB    . ILE A 1 227 ? 77.440  82.502  93.929  1.00 123.31 ? 219 ILE A CB    1 
ATOM   689   C  CG1   . ILE A 1 227 ? 76.440  82.843  92.823  1.00 123.51 ? 219 ILE A CG1   1 
ATOM   690   C  CG2   . ILE A 1 227 ? 77.400  83.542  95.038  1.00 120.35 ? 219 ILE A CG2   1 
ATOM   691   C  CD1   . ILE A 1 227 ? 75.016  82.983  93.312  1.00 121.82 ? 219 ILE A CD1   1 
ATOM   692   N  N     . TYR A 1 228 ? 79.972  84.544  93.272  1.00 117.67 ? 220 TYR A N     1 
ATOM   693   C  CA    . TYR A 1 228 ? 80.454  85.746  92.604  1.00 114.30 ? 220 TYR A CA    1 
ATOM   694   C  C     . TYR A 1 228 ? 81.447  85.430  91.495  1.00 110.46 ? 220 TYR A C     1 
ATOM   695   O  O     . TYR A 1 228 ? 81.667  86.272  90.617  1.00 106.36 ? 220 TYR A O     1 
ATOM   696   C  CB    . TYR A 1 228 ? 81.099  86.693  93.617  1.00 108.53 ? 220 TYR A CB    1 
ATOM   697   C  CG    . TYR A 1 228 ? 80.152  87.201  94.679  1.00 107.62 ? 220 TYR A CG    1 
ATOM   698   C  CD1   . TYR A 1 228 ? 79.369  88.326  94.458  1.00 103.20 ? 220 TYR A CD1   1 
ATOM   699   C  CD2   . TYR A 1 228 ? 80.046  86.561  95.906  1.00 109.10 ? 220 TYR A CD2   1 
ATOM   700   C  CE1   . TYR A 1 228 ? 78.504  88.797  95.427  1.00 99.94  ? 220 TYR A CE1   1 
ATOM   701   C  CE2   . TYR A 1 228 ? 79.185  87.024  96.881  1.00 108.18 ? 220 TYR A CE2   1 
ATOM   702   C  CZ    . TYR A 1 228 ? 78.417  88.142  96.637  1.00 104.29 ? 220 TYR A CZ    1 
ATOM   703   O  OH    . TYR A 1 228 ? 77.557  88.606  97.605  1.00 103.75 ? 220 TYR A OH    1 
ATOM   704   N  N     . GLY A 1 229 ? 82.053  84.244  91.514  1.00 112.77 ? 221 GLY A N     1 
ATOM   705   C  CA    . GLY A 1 229 ? 82.937  83.852  90.436  1.00 114.27 ? 221 GLY A CA    1 
ATOM   706   C  C     . GLY A 1 229 ? 82.243  83.443  89.157  1.00 117.04 ? 221 GLY A C     1 
ATOM   707   O  O     . GLY A 1 229 ? 82.903  83.331  88.121  1.00 115.28 ? 221 GLY A O     1 
ATOM   708   N  N     . LEU A 1 230 ? 80.931  83.223  89.202  1.00 119.19 ? 222 LEU A N     1 
ATOM   709   C  CA    . LEU A 1 230 ? 80.168  82.808  88.033  1.00 115.67 ? 222 LEU A CA    1 
ATOM   710   C  C     . LEU A 1 230 ? 79.547  83.976  87.279  1.00 111.15 ? 222 LEU A C     1 
ATOM   711   O  O     . LEU A 1 230 ? 78.834  83.750  86.297  1.00 112.24 ? 222 LEU A O     1 
ATOM   712   C  CB    . LEU A 1 230 ? 79.065  81.828  88.446  1.00 120.80 ? 222 LEU A CB    1 
ATOM   713   C  CG    . LEU A 1 230 ? 79.501  80.516  89.101  1.00 124.70 ? 222 LEU A CG    1 
ATOM   714   C  CD1   . LEU A 1 230 ? 78.299  79.775  89.662  1.00 133.06 ? 222 LEU A CD1   1 
ATOM   715   C  CD2   . LEU A 1 230 ? 80.242  79.646  88.105  1.00 121.81 ? 222 LEU A CD2   1 
ATOM   716   N  N     . MET A 1 231 ? 79.798  85.212  87.708  1.00 110.15 ? 223 MET A N     1 
ATOM   717   C  CA    . MET A 1 231 ? 79.115  86.367  87.143  1.00 107.24 ? 223 MET A CA    1 
ATOM   718   C  C     . MET A 1 231 ? 79.780  86.920  85.890  1.00 103.29 ? 223 MET A C     1 
ATOM   719   O  O     . MET A 1 231 ? 79.120  87.631  85.122  1.00 102.50 ? 223 MET A O     1 
ATOM   720   C  CB    . MET A 1 231 ? 79.007  87.474  88.195  1.00 105.25 ? 223 MET A CB    1 
ATOM   721   C  CG    . MET A 1 231 ? 78.254  87.039  89.440  1.00 111.88 ? 223 MET A CG    1 
ATOM   722   S  SD    . MET A 1 231 ? 78.075  88.333  90.677  1.00 115.17 ? 223 MET A SD    1 
ATOM   723   C  CE    . MET A 1 231 ? 77.118  87.458  91.913  1.00 114.54 ? 223 MET A CE    1 
ATOM   724   N  N     . LYS A 1 232 ? 81.054  86.599  85.648  1.00 98.72  ? 224 LYS A N     1 
ATOM   725   C  CA    . LYS A 1 232 ? 81.727  87.117  84.462  1.00 93.73  ? 224 LYS A CA    1 
ATOM   726   C  C     . LYS A 1 232 ? 81.062  86.651  83.174  1.00 101.64 ? 224 LYS A C     1 
ATOM   727   O  O     . LYS A 1 232 ? 81.283  87.257  82.120  1.00 103.24 ? 224 LYS A O     1 
ATOM   728   C  CB    . LYS A 1 232 ? 83.201  86.715  84.466  1.00 89.70  ? 224 LYS A CB    1 
ATOM   729   C  CG    . LYS A 1 232 ? 84.064  87.554  85.389  1.00 82.34  ? 224 LYS A CG    1 
ATOM   730   C  CD    . LYS A 1 232 ? 85.530  87.179  85.275  1.00 76.79  ? 224 LYS A CD    1 
ATOM   731   C  CE    . LYS A 1 232 ? 85.778  85.763  85.758  1.00 85.67  ? 224 LYS A CE    1 
ATOM   732   N  NZ    . LYS A 1 232 ? 87.224  85.414  85.714  1.00 79.84  ? 224 LYS A NZ    1 
ATOM   733   N  N     . LEU A 1 233 ? 80.257  85.589  83.236  1.00 104.55 ? 225 LEU A N     1 
ATOM   734   C  CA    . LEU A 1 233 ? 79.515  85.149  82.061  1.00 102.48 ? 225 LEU A CA    1 
ATOM   735   C  C     . LEU A 1 233 ? 78.427  86.147  81.681  1.00 101.95 ? 225 LEU A C     1 
ATOM   736   O  O     . LEU A 1 233 ? 78.171  86.367  80.492  1.00 105.19 ? 225 LEU A O     1 
ATOM   737   C  CB    . LEU A 1 233 ? 78.907  83.771  82.315  1.00 109.53 ? 225 LEU A CB    1 
ATOM   738   C  CG    . LEU A 1 233 ? 79.881  82.616  82.550  1.00 113.60 ? 225 LEU A CG    1 
ATOM   739   C  CD1   . LEU A 1 233 ? 79.153  81.417  83.133  1.00 117.67 ? 225 LEU A CD1   1 
ATOM   740   C  CD2   . LEU A 1 233 ? 80.572  82.237  81.253  1.00 114.40 ? 225 LEU A CD2   1 
ATOM   741   N  N     . VAL A 1 234 ? 77.779  86.759  82.668  1.00 101.09 ? 226 VAL A N     1 
ATOM   742   C  CA    . VAL A 1 234 ? 76.585  87.560  82.424  1.00 100.06 ? 226 VAL A CA    1 
ATOM   743   C  C     . VAL A 1 234 ? 76.912  89.052  82.325  1.00 95.91  ? 226 VAL A C     1 
ATOM   744   O  O     . VAL A 1 234 ? 76.009  89.886  82.387  1.00 96.07  ? 226 VAL A O     1 
ATOM   745   C  CB    . VAL A 1 234 ? 75.505  87.298  83.484  1.00 98.75  ? 226 VAL A CB    1 
ATOM   746   C  CG1   . VAL A 1 234 ? 75.171  85.817  83.545  1.00 105.30 ? 226 VAL A CG1   1 
ATOM   747   C  CG2   . VAL A 1 234 ? 75.956  87.803  84.843  1.00 97.17  ? 226 VAL A CG2   1 
ATOM   748   N  N     . LEU A 1 235 ? 78.189  89.402  82.152  1.00 93.87  ? 227 LEU A N     1 
ATOM   749   C  CA    . LEU A 1 235 ? 78.565  90.811  82.082  1.00 91.49  ? 227 LEU A CA    1 
ATOM   750   C  C     . LEU A 1 235 ? 77.890  91.509  80.909  1.00 93.54  ? 227 LEU A C     1 
ATOM   751   O  O     . LEU A 1 235 ? 77.494  92.675  81.017  1.00 94.78  ? 227 LEU A O     1 
ATOM   752   C  CB    . LEU A 1 235 ? 80.083  90.947  81.984  1.00 86.61  ? 227 LEU A CB    1 
ATOM   753   C  CG    . LEU A 1 235 ? 80.867  90.364  83.158  1.00 92.73  ? 227 LEU A CG    1 
ATOM   754   C  CD1   . LEU A 1 235 ? 82.343  90.696  83.035  1.00 84.64  ? 227 LEU A CD1   1 
ATOM   755   C  CD2   . LEU A 1 235 ? 80.311  90.860  84.483  1.00 91.67  ? 227 LEU A CD2   1 
ATOM   756   N  N     . THR A 1 236 ? 77.743  90.808  79.781  1.00 95.20  ? 228 THR A N     1 
ATOM   757   C  CA    . THR A 1 236 ? 77.052  91.386  78.633  1.00 95.41  ? 228 THR A CA    1 
ATOM   758   C  C     . THR A 1 236 ? 75.624  91.780  78.981  1.00 95.47  ? 228 THR A C     1 
ATOM   759   O  O     . THR A 1 236 ? 75.087  92.735  78.408  1.00 90.69  ? 228 THR A O     1 
ATOM   760   C  CB    . THR A 1 236 ? 77.054  90.401  77.465  1.00 98.38  ? 228 THR A CB    1 
ATOM   761   O  OG1   . THR A 1 236 ? 76.327  89.222  77.832  1.00 101.62 ? 228 THR A OG1   1 
ATOM   762   C  CG2   . THR A 1 236 ? 78.476  90.015  77.098  1.00 97.78  ? 228 THR A CG2   1 
ATOM   763   N  N     . LYS A 1 237 ? 74.994  91.060  79.910  1.00 99.90  ? 229 LYS A N     1 
ATOM   764   C  CA    . LYS A 1 237 ? 73.653  91.427  80.348  1.00 101.53 ? 229 LYS A CA    1 
ATOM   765   C  C     . LYS A 1 237 ? 73.668  92.643  81.265  1.00 99.40  ? 229 LYS A C     1 
ATOM   766   O  O     . LYS A 1 237 ? 72.696  93.406  81.291  1.00 98.02  ? 229 LYS A O     1 
ATOM   767   C  CB    . LYS A 1 237 ? 72.990  90.242  81.052  1.00 105.47 ? 229 LYS A CB    1 
ATOM   768   C  CG    . LYS A 1 237 ? 71.545  90.483  81.451  1.00 113.23 ? 229 LYS A CG    1 
ATOM   769   C  CD    . LYS A 1 237 ? 70.929  89.253  82.094  1.00 119.62 ? 229 LYS A CD    1 
ATOM   770   C  CE    . LYS A 1 237 ? 69.479  89.505  82.471  1.00 122.97 ? 229 LYS A CE    1 
ATOM   771   N  NZ    . LYS A 1 237 ? 68.832  88.294  83.045  1.00 124.69 ? 229 LYS A NZ    1 
ATOM   772   N  N     . THR A 1 238 ? 74.757  92.848  82.006  1.00 95.34  ? 230 THR A N     1 
ATOM   773   C  CA    . THR A 1 238 ? 74.815  93.906  83.008  1.00 87.99  ? 230 THR A CA    1 
ATOM   774   C  C     . THR A 1 238 ? 75.370  95.212  82.455  1.00 83.03  ? 230 THR A C     1 
ATOM   775   O  O     . THR A 1 238 ? 74.836  96.285  82.754  1.00 79.82  ? 230 THR A O     1 
ATOM   776   C  CB    . THR A 1 238 ? 75.662  93.452  84.198  1.00 88.68  ? 230 THR A CB    1 
ATOM   777   O  OG1   . THR A 1 238 ? 75.199  92.175  84.651  1.00 95.34  ? 230 THR A OG1   1 
ATOM   778   C  CG2   . THR A 1 238 ? 75.558  94.450  85.337  1.00 81.30  ? 230 THR A CG2   1 
ATOM   779   N  N     . LEU A 1 239 ? 76.430  95.144  81.655  1.00 85.13  ? 231 LEU A N     1 
ATOM   780   C  CA    . LEU A 1 239 ? 77.072  96.350  81.164  1.00 80.86  ? 231 LEU A CA    1 
ATOM   781   C  C     . LEU A 1 239 ? 76.143  97.104  80.213  1.00 85.63  ? 231 LEU A C     1 
ATOM   782   O  O     . LEU A 1 239 ? 75.249  96.509  79.605  1.00 89.25  ? 231 LEU A O     1 
ATOM   783   C  CB    . LEU A 1 239 ? 78.380  96.004  80.457  1.00 80.30  ? 231 LEU A CB    1 
ATOM   784   C  CG    . LEU A 1 239 ? 79.453  95.362  81.337  1.00 82.26  ? 231 LEU A CG    1 
ATOM   785   C  CD1   . LEU A 1 239 ? 80.723  95.119  80.544  1.00 77.40  ? 231 LEU A CD1   1 
ATOM   786   C  CD2   . LEU A 1 239 ? 79.735  96.227  82.553  1.00 73.71  ? 231 LEU A CD2   1 
ATOM   787   N  N     . PRO A 1 240 ? 76.322  98.419  80.083  1.00 84.11  ? 232 PRO A N     1 
ATOM   788   C  CA    . PRO A 1 240 ? 75.435  99.203  79.218  1.00 84.32  ? 232 PRO A CA    1 
ATOM   789   C  C     . PRO A 1 240 ? 75.500  98.741  77.770  1.00 84.69  ? 232 PRO A C     1 
ATOM   790   O  O     . PRO A 1 240 ? 76.539  98.295  77.279  1.00 83.55  ? 232 PRO A O     1 
ATOM   791   C  CB    . PRO A 1 240 ? 75.962  100.633 79.371  1.00 83.05  ? 232 PRO A CB    1 
ATOM   792   C  CG    . PRO A 1 240 ? 76.662  100.637 80.684  1.00 77.16  ? 232 PRO A CG    1 
ATOM   793   C  CD    . PRO A 1 240 ? 77.269  99.275  80.818  1.00 79.33  ? 232 PRO A CD    1 
ATOM   794   N  N     . ALA A 1 241 ? 74.359  98.855  77.085  1.00 83.42  ? 233 ALA A N     1 
ATOM   795   C  CA    . ALA A 1 241 ? 74.252  98.377  75.713  1.00 82.34  ? 233 ALA A CA    1 
ATOM   796   C  C     . ALA A 1 241 ? 75.063  99.211  74.730  1.00 85.40  ? 233 ALA A C     1 
ATOM   797   O  O     . ALA A 1 241 ? 75.347  98.737  73.625  1.00 89.58  ? 233 ALA A O     1 
ATOM   798   C  CB    . ALA A 1 241 ? 72.786  98.349  75.281  1.00 83.13  ? 233 ALA A CB    1 
ATOM   799   N  N     . ASN A 1 242 ? 75.443  100.435 75.096  1.00 84.36  ? 234 ASN A N     1 
ATOM   800   C  CA    . ASN A 1 242 ? 76.188  101.291 74.183  1.00 86.26  ? 234 ASN A CA    1 
ATOM   801   C  C     . ASN A 1 242 ? 77.685  101.014 74.191  1.00 85.04  ? 234 ASN A C     1 
ATOM   802   O  O     . ASN A 1 242 ? 78.412  101.613 73.391  1.00 85.69  ? 234 ASN A O     1 
ATOM   803   C  CB    . ASN A 1 242 ? 75.942  102.764 74.517  1.00 89.34  ? 234 ASN A CB    1 
ATOM   804   C  CG    . ASN A 1 242 ? 76.528  103.163 75.854  1.00 90.73  ? 234 ASN A CG    1 
ATOM   805   O  OD1   . ASN A 1 242 ? 76.622  102.348 76.770  1.00 91.81  ? 234 ASN A OD1   1 
ATOM   806   N  ND2   . ASN A 1 242 ? 76.929  104.423 75.972  1.00 90.58  ? 234 ASN A ND2   1 
ATOM   807   N  N     . LEU A 1 243 ? 78.162  100.132 75.066  1.00 83.67  ? 235 LEU A N     1 
ATOM   808   C  CA    . LEU A 1 243 ? 79.578  99.806  75.144  1.00 81.02  ? 235 LEU A CA    1 
ATOM   809   C  C     . LEU A 1 243 ? 79.918  98.688  74.167  1.00 82.52  ? 235 LEU A C     1 
ATOM   810   O  O     . LEU A 1 243 ? 79.178  97.708  74.043  1.00 86.02  ? 235 LEU A O     1 
ATOM   811   C  CB    . LEU A 1 243 ? 79.955  99.394  76.568  1.00 80.39  ? 235 LEU A CB    1 
ATOM   812   C  CG    . LEU A 1 243 ? 81.433  99.092  76.813  1.00 73.96  ? 235 LEU A CG    1 
ATOM   813   C  CD1   . LEU A 1 243 ? 82.288  100.263 76.366  1.00 69.14  ? 235 LEU A CD1   1 
ATOM   814   C  CD2   . LEU A 1 243 ? 81.676  98.773  78.279  1.00 64.08  ? 235 LEU A CD2   1 
ATOM   815   N  N     . GLU A 1 244 ? 81.048  98.841  73.476  1.00 79.58  ? 236 GLU A N     1 
ATOM   816   C  CA    . GLU A 1 244 ? 81.467  97.896  72.446  1.00 80.09  ? 236 GLU A CA    1 
ATOM   817   C  C     . GLU A 1 244 ? 82.507  96.905  72.958  1.00 76.75  ? 236 GLU A C     1 
ATOM   818   O  O     . GLU A 1 244 ? 82.300  95.690  72.888  1.00 79.03  ? 236 GLU A O     1 
ATOM   819   C  CB    . GLU A 1 244 ? 82.015  98.656  71.231  1.00 88.93  ? 236 GLU A CB    1 
ATOM   820   C  CG    . GLU A 1 244 ? 81.045  99.658  70.630  1.00 99.85  ? 236 GLU A CG    1 
ATOM   821   C  CD    . GLU A 1 244 ? 81.647  100.419 69.465  1.00 114.32 ? 236 GLU A CD    1 
ATOM   822   O  OE1   . GLU A 1 244 ? 82.826  100.169 69.137  1.00 118.04 ? 236 GLU A OE1   1 
ATOM   823   O  OE2   . GLU A 1 244 ? 80.942  101.267 68.878  1.00 113.53 ? 236 GLU A OE2   1 
ATOM   824   N  N     . ARG A 1 245 ? 83.626  97.404  73.474  1.00 72.25  ? 237 ARG A N     1 
ATOM   825   C  CA    . ARG A 1 245 ? 84.746  96.571  73.882  1.00 67.44  ? 237 ARG A CA    1 
ATOM   826   C  C     . ARG A 1 245 ? 85.081  96.825  75.345  1.00 63.92  ? 237 ARG A C     1 
ATOM   827   O  O     . ARG A 1 245 ? 84.927  97.940  75.851  1.00 64.05  ? 237 ARG A O     1 
ATOM   828   C  CB    . ARG A 1 245 ? 85.977  96.843  73.013  1.00 70.70  ? 237 ARG A CB    1 
ATOM   829   C  CG    . ARG A 1 245 ? 85.727  96.695  71.524  1.00 74.27  ? 237 ARG A CG    1 
ATOM   830   C  CD    . ARG A 1 245 ? 86.914  97.187  70.717  1.00 76.50  ? 237 ARG A CD    1 
ATOM   831   N  NE    . ARG A 1 245 ? 87.230  98.579  71.014  1.00 80.48  ? 237 ARG A NE    1 
ATOM   832   C  CZ    . ARG A 1 245 ? 88.187  99.273  70.414  1.00 80.84  ? 237 ARG A CZ    1 
ATOM   833   N  NH1   . ARG A 1 245 ? 88.943  98.736  69.472  1.00 78.30  ? 237 ARG A NH1   1 
ATOM   834   N  NH2   . ARG A 1 245 ? 88.389  100.539 70.768  1.00 81.02  ? 237 ARG A NH2   1 
ATOM   835   N  N     . VAL A 1 246 ? 85.548  95.774  76.023  1.00 59.56  ? 238 VAL A N     1 
ATOM   836   C  CA    . VAL A 1 246 ? 85.861  95.846  77.445  1.00 51.32  ? 238 VAL A CA    1 
ATOM   837   C  C     . VAL A 1 246 ? 86.973  94.855  77.767  1.00 51.80  ? 238 VAL A C     1 
ATOM   838   O  O     . VAL A 1 246 ? 87.185  93.867  77.059  1.00 56.84  ? 238 VAL A O     1 
ATOM   839   C  CB    . VAL A 1 246 ? 84.610  95.576  78.318  1.00 56.30  ? 238 VAL A CB    1 
ATOM   840   C  CG1   . VAL A 1 246 ? 84.287  94.093  78.359  1.00 55.36  ? 238 VAL A CG1   1 
ATOM   841   C  CG2   . VAL A 1 246 ? 84.791  96.141  79.721  1.00 53.96  ? 238 VAL A CG2   1 
ATOM   842   N  N     . ILE A 1 247 ? 87.704  95.143  78.841  1.00 47.76  ? 239 ILE A N     1 
ATOM   843   C  CA    . ILE A 1 247 ? 88.746  94.270  79.367  1.00 43.29  ? 239 ILE A CA    1 
ATOM   844   C  C     . ILE A 1 247 ? 88.280  93.784  80.731  1.00 44.76  ? 239 ILE A C     1 
ATOM   845   O  O     . ILE A 1 247 ? 88.193  94.569  81.680  1.00 50.10  ? 239 ILE A O     1 
ATOM   846   C  CB    . ILE A 1 247 ? 90.095  94.992  79.474  1.00 39.58  ? 239 ILE A CB    1 
ATOM   847   C  CG1   . ILE A 1 247 ? 90.486  95.607  78.131  1.00 43.93  ? 239 ILE A CG1   1 
ATOM   848   C  CG2   . ILE A 1 247 ? 91.171  94.042  79.965  1.00 42.98  ? 239 ILE A CG2   1 
ATOM   849   C  CD1   . ILE A 1 247 ? 91.812  96.323  78.163  1.00 45.72  ? 239 ILE A CD1   1 
ATOM   850   N  N     . VAL A 1 248 ? 87.979  92.499  80.839  1.00 42.01  ? 240 VAL A N     1 
ATOM   851   C  CA    . VAL A 1 248 ? 87.521  91.912  82.091  1.00 40.77  ? 240 VAL A CA    1 
ATOM   852   C  C     . VAL A 1 248 ? 88.729  91.401  82.862  1.00 45.91  ? 240 VAL A C     1 
ATOM   853   O  O     . VAL A 1 248 ? 89.554  90.655  82.321  1.00 52.22  ? 240 VAL A O     1 
ATOM   854   C  CB    . VAL A 1 248 ? 86.513  90.781  81.831  1.00 42.97  ? 240 VAL A CB    1 
ATOM   855   C  CG1   . VAL A 1 248 ? 86.030  90.191  83.142  1.00 41.94  ? 240 VAL A CG1   1 
ATOM   856   C  CG2   . VAL A 1 248 ? 85.348  91.296  81.010  1.00 41.25  ? 240 VAL A CG2   1 
ATOM   857   N  N     . LEU A 1 249 ? 88.834  91.800  84.126  1.00 48.22  ? 241 LEU A N     1 
ATOM   858   C  CA    . LEU A 1 249 ? 89.965  91.432  84.962  1.00 47.06  ? 241 LEU A CA    1 
ATOM   859   C  C     . LEU A 1 249 ? 89.491  90.747  86.237  1.00 46.87  ? 241 LEU A C     1 
ATOM   860   O  O     . LEU A 1 249 ? 88.318  90.817  86.612  1.00 49.07  ? 241 LEU A O     1 
ATOM   861   C  CB    . LEU A 1 249 ? 90.813  92.657  85.324  1.00 47.48  ? 241 LEU A CB    1 
ATOM   862   C  CG    . LEU A 1 249 ? 91.500  93.377  84.166  1.00 42.70  ? 241 LEU A CG    1 
ATOM   863   C  CD1   . LEU A 1 249 ? 92.394  94.487  84.689  1.00 43.45  ? 241 LEU A CD1   1 
ATOM   864   C  CD2   . LEU A 1 249 ? 92.296  92.396  83.327  1.00 43.30  ? 241 LEU A CD2   1 
ATOM   865   N  N     . ASP A 1 250 ? 90.425  90.067  86.893  1.00 49.77  ? 242 ASP A N     1 
ATOM   866   C  CA    . ASP A 1 250 ? 90.210  89.493  88.210  1.00 53.74  ? 242 ASP A CA    1 
ATOM   867   C  C     . ASP A 1 250 ? 90.936  90.323  89.260  1.00 52.56  ? 242 ASP A C     1 
ATOM   868   O  O     . ASP A 1 250 ? 91.832  91.112  88.953  1.00 51.62  ? 242 ASP A O     1 
ATOM   869   C  CB    . ASP A 1 250 ? 90.683  88.037  88.267  1.00 54.95  ? 242 ASP A CB    1 
ATOM   870   C  CG    . ASP A 1 250 ? 89.671  87.077  87.681  1.00 64.09  ? 242 ASP A CG    1 
ATOM   871   O  OD1   . ASP A 1 250 ? 88.634  87.547  87.169  1.00 63.76  ? 242 ASP A OD1   1 
ATOM   872   O  OD2   . ASP A 1 250 ? 89.908  85.853  87.737  1.00 69.43  ? 242 ASP A OD2   1 
ATOM   873   N  N     . THR A 1 251 ? 90.532  90.133  90.516  1.00 50.38  ? 243 THR A N     1 
ATOM   874   C  CA    . THR A 1 251 ? 91.068  90.943  91.602  1.00 49.35  ? 243 THR A CA    1 
ATOM   875   C  C     . THR A 1 251 ? 92.537  90.654  91.885  1.00 51.34  ? 243 THR A C     1 
ATOM   876   O  O     . THR A 1 251 ? 93.211  91.490  92.495  1.00 52.66  ? 243 THR A O     1 
ATOM   877   C  CB    . THR A 1 251 ? 90.241  90.723  92.868  1.00 53.10  ? 243 THR A CB    1 
ATOM   878   O  OG1   . THR A 1 251 ? 90.213  89.326  93.184  1.00 60.22  ? 243 THR A OG1   1 
ATOM   879   C  CG2   . THR A 1 251 ? 88.821  91.218  92.663  1.00 48.01  ? 243 THR A CG2   1 
ATOM   880   N  N     . ASP A 1 252 ? 93.049  89.506  91.448  1.00 52.75  ? 244 ASP A N     1 
ATOM   881   C  CA    . ASP A 1 252 ? 94.427  89.094  91.712  1.00 48.91  ? 244 ASP A CA    1 
ATOM   882   C  C     . ASP A 1 252 ? 95.340  89.351  90.521  1.00 49.54  ? 244 ASP A C     1 
ATOM   883   O  O     . ASP A 1 252 ? 96.274  88.588  90.265  1.00 50.61  ? 244 ASP A O     1 
ATOM   884   C  CB    . ASP A 1 252 ? 94.462  87.624  92.112  1.00 49.01  ? 244 ASP A CB    1 
ATOM   885   C  CG    . ASP A 1 252 ? 93.573  86.766  91.242  1.00 52.46  ? 244 ASP A CG    1 
ATOM   886   O  OD1   . ASP A 1 252 ? 93.153  87.245  90.170  1.00 54.26  ? 244 ASP A OD1   1 
ATOM   887   O  OD2   . ASP A 1 252 ? 93.284  85.616  91.630  1.00 56.52  ? 244 ASP A OD2   1 
ATOM   888   N  N     . ILE A 1 253 ? 95.094  90.429  89.782  1.00 51.53  ? 245 ILE A N     1 
ATOM   889   C  CA    . ILE A 1 253 ? 95.847  90.768  88.581  1.00 46.56  ? 245 ILE A CA    1 
ATOM   890   C  C     . ILE A 1 253 ? 96.722  91.976  88.880  1.00 45.79  ? 245 ILE A C     1 
ATOM   891   O  O     . ILE A 1 253 ? 96.305  92.896  89.592  1.00 50.71  ? 245 ILE A O     1 
ATOM   892   C  CB    . ILE A 1 253 ? 94.901  91.047  87.396  1.00 45.86  ? 245 ILE A CB    1 
ATOM   893   C  CG1   . ILE A 1 253 ? 94.111  89.789  87.033  1.00 50.15  ? 245 ILE A CG1   1 
ATOM   894   C  CG2   . ILE A 1 253 ? 95.669  91.549  86.190  1.00 47.68  ? 245 ILE A CG2   1 
ATOM   895   C  CD1   . ILE A 1 253 ? 94.961  88.676  86.475  1.00 54.36  ? 245 ILE A CD1   1 
ATOM   896   N  N     . THR A 1 254 ? 97.943  91.964  88.352  1.00 45.00  ? 246 THR A N     1 
ATOM   897   C  CA    . THR A 1 254 ? 98.859  93.088  88.461  1.00 49.73  ? 246 THR A CA    1 
ATOM   898   C  C     . THR A 1 254 ? 99.372  93.439  87.073  1.00 52.61  ? 246 THR A C     1 
ATOM   899   O  O     . THR A 1 254 ? 99.672  92.550  86.271  1.00 57.28  ? 246 THR A O     1 
ATOM   900   C  CB    . THR A 1 254 ? 100.033 92.767  89.392  1.00 55.75  ? 246 THR A CB    1 
ATOM   901   O  OG1   . THR A 1 254 ? 99.535  92.227  90.621  1.00 60.65  ? 246 THR A OG1   1 
ATOM   902   C  CG2   . THR A 1 254 ? 100.834 94.022  89.692  1.00 59.58  ? 246 THR A CG2   1 
ATOM   903   N  N     . PHE A 1 255 ? 99.466  94.733  86.791  1.00 54.30  ? 247 PHE A N     1 
ATOM   904   C  CA    . PHE A 1 255 ? 99.902  95.227  85.493  1.00 57.77  ? 247 PHE A CA    1 
ATOM   905   C  C     . PHE A 1 255 ? 101.307 95.801  85.605  1.00 63.98  ? 247 PHE A C     1 
ATOM   906   O  O     . PHE A 1 255 ? 101.565 96.665  86.450  1.00 62.06  ? 247 PHE A O     1 
ATOM   907   C  CB    . PHE A 1 255 ? 98.940  96.292  84.961  1.00 53.36  ? 247 PHE A CB    1 
ATOM   908   C  CG    . PHE A 1 255 ? 97.819  95.736  84.135  1.00 45.06  ? 247 PHE A CG    1 
ATOM   909   C  CD1   . PHE A 1 255 ? 96.917  94.839  84.678  1.00 46.47  ? 247 PHE A CD1   1 
ATOM   910   C  CD2   . PHE A 1 255 ? 97.661  96.118  82.816  1.00 48.55  ? 247 PHE A CD2   1 
ATOM   911   C  CE1   . PHE A 1 255 ? 95.886  94.328  83.918  1.00 45.07  ? 247 PHE A CE1   1 
ATOM   912   C  CE2   . PHE A 1 255 ? 96.631  95.610  82.052  1.00 51.85  ? 247 PHE A CE2   1 
ATOM   913   C  CZ    . PHE A 1 255 ? 95.742  94.715  82.604  1.00 47.64  ? 247 PHE A CZ    1 
ATOM   914   N  N     . ALA A 1 256 ? 102.209 95.316  84.754  1.00 64.32  ? 248 ALA A N     1 
ATOM   915   C  CA    . ALA A 1 256 ? 103.553 95.861  84.644  1.00 68.74  ? 248 ALA A CA    1 
ATOM   916   C  C     . ALA A 1 256 ? 103.766 96.629  83.348  1.00 71.92  ? 248 ALA A C     1 
ATOM   917   O  O     . ALA A 1 256 ? 104.884 97.083  83.088  1.00 77.30  ? 248 ALA A O     1 
ATOM   918   C  CB    . ALA A 1 256 ? 104.594 94.743  84.759  1.00 76.20  ? 248 ALA A CB    1 
ATOM   919   N  N     . THR A 1 257 ? 102.725 96.786  82.534  1.00 68.78  ? 249 THR A N     1 
ATOM   920   C  CA    . THR A 1 257 ? 102.810 97.522  81.282  1.00 71.22  ? 249 THR A CA    1 
ATOM   921   C  C     . THR A 1 257 ? 101.553 98.364  81.126  1.00 68.99  ? 249 THR A C     1 
ATOM   922   O  O     . THR A 1 257 ? 100.571 98.195  81.854  1.00 67.78  ? 249 THR A O     1 
ATOM   923   C  CB    . THR A 1 257 ? 102.973 96.586  80.080  1.00 75.29  ? 249 THR A CB    1 
ATOM   924   O  OG1   . THR A 1 257 ? 103.436 97.335  78.950  1.00 80.14  ? 249 THR A OG1   1 
ATOM   925   C  CG2   . THR A 1 257 ? 101.641 95.942  79.731  1.00 71.09  ? 249 THR A CG2   1 
ATOM   926   N  N     . ASP A 1 258 ? 101.595 99.285  80.167  1.00 70.94  ? 250 ASP A N     1 
ATOM   927   C  CA    . ASP A 1 258 ? 100.445 100.138 79.900  1.00 71.13  ? 250 ASP A CA    1 
ATOM   928   C  C     . ASP A 1 258 ? 99.265  99.302  79.425  1.00 70.44  ? 250 ASP A C     1 
ATOM   929   O  O     . ASP A 1 258 ? 99.413  98.419  78.577  1.00 71.05  ? 250 ASP A O     1 
ATOM   930   C  CB    . ASP A 1 258 ? 100.805 101.192 78.853  1.00 76.55  ? 250 ASP A CB    1 
ATOM   931   C  CG    . ASP A 1 258 ? 99.704  102.216 78.649  1.00 80.41  ? 250 ASP A CG    1 
ATOM   932   O  OD1   . ASP A 1 258 ? 98.693  102.168 79.380  1.00 77.97  ? 250 ASP A OD1   1 
ATOM   933   O  OD2   . ASP A 1 258 ? 99.852  103.075 77.755  1.00 83.64  ? 250 ASP A OD2   1 
ATOM   934   N  N     . ILE A 1 259 ? 98.085  99.585  79.982  1.00 70.78  ? 251 ILE A N     1 
ATOM   935   C  CA    . ILE A 1 259 ? 96.882  98.875  79.568  1.00 67.51  ? 251 ILE A CA    1 
ATOM   936   C  C     . ILE A 1 259 ? 96.453  99.293  78.168  1.00 68.03  ? 251 ILE A C     1 
ATOM   937   O  O     . ILE A 1 259 ? 95.686  98.575  77.514  1.00 68.40  ? 251 ILE A O     1 
ATOM   938   C  CB    . ILE A 1 259 ? 95.756  99.096  80.596  1.00 64.74  ? 251 ILE A CB    1 
ATOM   939   C  CG1   . ILE A 1 259 ? 94.628  98.084  80.387  1.00 55.81  ? 251 ILE A CG1   1 
ATOM   940   C  CG2   . ILE A 1 259 ? 95.230  100.519 80.518  1.00 63.71  ? 251 ILE A CG2   1 
ATOM   941   C  CD1   . ILE A 1 259 ? 93.601  98.086  81.487  1.00 55.54  ? 251 ILE A CD1   1 
ATOM   942   N  N     . ALA A 1 260 ? 96.937  100.441 77.686  1.00 67.96  ? 252 ALA A N     1 
ATOM   943   C  CA    . ALA A 1 260 ? 96.658  100.838 76.311  1.00 67.20  ? 252 ALA A CA    1 
ATOM   944   C  C     . ALA A 1 260 ? 97.241  99.844  75.319  1.00 67.90  ? 252 ALA A C     1 
ATOM   945   O  O     . ALA A 1 260 ? 96.677  99.645  74.238  1.00 67.76  ? 252 ALA A O     1 
ATOM   946   C  CB    . ALA A 1 260 ? 97.205  102.239 76.046  1.00 70.42  ? 252 ALA A CB    1 
ATOM   947   N  N     . GLU A 1 261 ? 98.360  99.207  75.668  1.00 66.58  ? 253 GLU A N     1 
ATOM   948   C  CA    . GLU A 1 261 ? 98.924  98.178  74.802  1.00 66.87  ? 253 GLU A CA    1 
ATOM   949   C  C     . GLU A 1 261 ? 97.967  97.003  74.649  1.00 63.67  ? 253 GLU A C     1 
ATOM   950   O  O     . GLU A 1 261 ? 97.807  96.462  73.550  1.00 63.38  ? 253 GLU A O     1 
ATOM   951   C  CB    . GLU A 1 261 ? 100.269 97.710  75.355  1.00 68.55  ? 253 GLU A CB    1 
ATOM   952   C  CG    . GLU A 1 261 ? 101.277 98.827  75.552  1.00 71.67  ? 253 GLU A CG    1 
ATOM   953   C  CD    . GLU A 1 261 ? 102.593 98.329  76.115  1.00 81.50  ? 253 GLU A CD    1 
ATOM   954   O  OE1   . GLU A 1 261 ? 102.739 97.101  76.288  1.00 78.68  ? 253 GLU A OE1   1 
ATOM   955   O  OE2   . GLU A 1 261 ? 103.481 99.165  76.385  1.00 86.33  ? 253 GLU A OE2   1 
ATOM   956   N  N     . LEU A 1 262 ? 97.325  96.591  75.744  1.00 62.78  ? 254 LEU A N     1 
ATOM   957   C  CA    . LEU A 1 262 ? 96.339  95.519  75.659  1.00 62.57  ? 254 LEU A CA    1 
ATOM   958   C  C     . LEU A 1 262 ? 95.073  95.978  74.948  1.00 64.44  ? 254 LEU A C     1 
ATOM   959   O  O     . LEU A 1 262 ? 94.440  95.186  74.240  1.00 62.22  ? 254 LEU A O     1 
ATOM   960   C  CB    . LEU A 1 262 ? 96.008  94.997  77.057  1.00 56.67  ? 254 LEU A CB    1 
ATOM   961   C  CG    . LEU A 1 262 ? 94.994  93.856  77.134  1.00 50.73  ? 254 LEU A CG    1 
ATOM   962   C  CD1   . LEU A 1 262 ? 95.443  92.687  76.282  1.00 56.73  ? 254 LEU A CD1   1 
ATOM   963   C  CD2   . LEU A 1 262 ? 94.789  93.422  78.572  1.00 49.69  ? 254 LEU A CD2   1 
ATOM   964   N  N     . TRP A 1 263 ? 94.683  97.242  75.129  1.00 66.50  ? 255 TRP A N     1 
ATOM   965   C  CA    . TRP A 1 263 ? 93.510  97.758  74.430  1.00 65.47  ? 255 TRP A CA    1 
ATOM   966   C  C     . TRP A 1 263 ? 93.746  97.839  72.928  1.00 66.96  ? 255 TRP A C     1 
ATOM   967   O  O     . TRP A 1 263 ? 92.802  97.692  72.143  1.00 69.10  ? 255 TRP A O     1 
ATOM   968   C  CB    . TRP A 1 263 ? 93.131  99.130  74.986  1.00 67.42  ? 255 TRP A CB    1 
ATOM   969   C  CG    . TRP A 1 263 ? 91.894  99.712  74.376  1.00 67.99  ? 255 TRP A CG    1 
ATOM   970   C  CD1   . TRP A 1 263 ? 91.831  100.650 73.389  1.00 69.76  ? 255 TRP A CD1   1 
ATOM   971   C  CD2   . TRP A 1 263 ? 90.539  99.397  74.716  1.00 67.63  ? 255 TRP A CD2   1 
ATOM   972   N  NE1   . TRP A 1 263 ? 90.522  100.939 73.093  1.00 70.64  ? 255 TRP A NE1   1 
ATOM   973   C  CE2   . TRP A 1 263 ? 89.709  100.182 73.894  1.00 69.67  ? 255 TRP A CE2   1 
ATOM   974   C  CE3   . TRP A 1 263 ? 89.947  98.526  75.634  1.00 64.38  ? 255 TRP A CE3   1 
ATOM   975   C  CZ2   . TRP A 1 263 ? 88.321  100.123 73.963  1.00 68.13  ? 255 TRP A CZ2   1 
ATOM   976   C  CZ3   . TRP A 1 263 ? 88.569  98.470  75.701  1.00 61.31  ? 255 TRP A CZ3   1 
ATOM   977   C  CH2   . TRP A 1 263 ? 87.771  99.263  74.871  1.00 63.84  ? 255 TRP A CH2   1 
ATOM   978   N  N     . ALA A 1 264 ? 94.991  98.075  72.512  1.00 66.53  ? 256 ALA A N     1 
ATOM   979   C  CA    . ALA A 1 264 ? 95.320  98.110  71.093  1.00 66.59  ? 256 ALA A CA    1 
ATOM   980   C  C     . ALA A 1 264 ? 95.175  96.749  70.430  1.00 69.13  ? 256 ALA A C     1 
ATOM   981   O  O     . ALA A 1 264 ? 95.042  96.684  69.204  1.00 77.53  ? 256 ALA A O     1 
ATOM   982   C  CB    . ALA A 1 264 ? 96.742  98.634  70.897  1.00 64.07  ? 256 ALA A CB    1 
ATOM   983   N  N     . VAL A 1 265 ? 95.198  95.663  71.207  1.00 64.53  ? 257 VAL A N     1 
ATOM   984   C  CA    . VAL A 1 265 ? 95.026  94.334  70.636  1.00 65.71  ? 257 VAL A CA    1 
ATOM   985   C  C     . VAL A 1 265 ? 93.630  94.153  70.056  1.00 68.43  ? 257 VAL A C     1 
ATOM   986   O  O     . VAL A 1 265 ? 93.416  93.263  69.226  1.00 70.96  ? 257 VAL A O     1 
ATOM   987   C  CB    . VAL A 1 265 ? 95.332  93.259  71.697  1.00 66.50  ? 257 VAL A CB    1 
ATOM   988   C  CG1   . VAL A 1 265 ? 95.425  91.881  71.062  1.00 64.00  ? 257 VAL A CG1   1 
ATOM   989   C  CG2   . VAL A 1 265 ? 96.622  93.592  72.428  1.00 66.65  ? 257 VAL A CG2   1 
ATOM   990   N  N     . PHE A 1 266 ? 92.669  94.986  70.462  1.00 70.69  ? 258 PHE A N     1 
ATOM   991   C  CA    . PHE A 1 266 ? 91.327  94.891  69.897  1.00 72.44  ? 258 PHE A CA    1 
ATOM   992   C  C     . PHE A 1 266 ? 91.325  95.167  68.399  1.00 75.07  ? 258 PHE A C     1 
ATOM   993   O  O     . PHE A 1 266 ? 90.468  94.648  67.675  1.00 77.14  ? 258 PHE A O     1 
ATOM   994   C  CB    . PHE A 1 266 ? 90.379  95.851  70.616  1.00 68.83  ? 258 PHE A CB    1 
ATOM   995   C  CG    . PHE A 1 266 ? 89.797  95.292  71.882  1.00 65.91  ? 258 PHE A CG    1 
ATOM   996   C  CD1   . PHE A 1 266 ? 88.876  94.260  71.839  1.00 64.60  ? 258 PHE A CD1   1 
ATOM   997   C  CD2   . PHE A 1 266 ? 90.161  95.806  73.114  1.00 66.62  ? 258 PHE A CD2   1 
ATOM   998   C  CE1   . PHE A 1 266 ? 88.335  93.745  73.000  1.00 61.40  ? 258 PHE A CE1   1 
ATOM   999   C  CE2   . PHE A 1 266 ? 89.623  95.295  74.278  1.00 63.54  ? 258 PHE A CE2   1 
ATOM   1000  C  CZ    . PHE A 1 266 ? 88.708  94.264  74.220  1.00 61.18  ? 258 PHE A CZ    1 
ATOM   1001  N  N     . HIS A 1 267 ? 92.273  95.973  67.915  1.00 73.97  ? 259 HIS A N     1 
ATOM   1002  C  CA    . HIS A 1 267 ? 92.358  96.248  66.487  1.00 73.29  ? 259 HIS A CA    1 
ATOM   1003  C  C     . HIS A 1 267 ? 92.753  95.020  65.679  1.00 72.26  ? 259 HIS A C     1 
ATOM   1004  O  O     . HIS A 1 267 ? 92.513  94.989  64.467  1.00 76.94  ? 259 HIS A O     1 
ATOM   1005  C  CB    . HIS A 1 267 ? 93.359  97.374  66.225  1.00 72.69  ? 259 HIS A CB    1 
ATOM   1006  C  CG    . HIS A 1 267 ? 93.011  98.663  66.902  1.00 77.52  ? 259 HIS A CG    1 
ATOM   1007  N  ND1   . HIS A 1 267 ? 91.785  99.275  66.750  1.00 82.18  ? 259 HIS A ND1   1 
ATOM   1008  C  CD2   . HIS A 1 267 ? 93.730  99.460  67.725  1.00 80.57  ? 259 HIS A CD2   1 
ATOM   1009  C  CE1   . HIS A 1 267 ? 91.763  100.391 67.456  1.00 86.38  ? 259 HIS A CE1   1 
ATOM   1010  N  NE2   . HIS A 1 267 ? 92.931  100.527 68.057  1.00 86.47  ? 259 HIS A NE2   1 
ATOM   1011  N  N     . LYS A 1 268 ? 93.345  94.014  66.314  1.00 68.31  ? 260 LYS A N     1 
ATOM   1012  C  CA    . LYS A 1 268 ? 93.854  92.844  65.615  1.00 70.80  ? 260 LYS A CA    1 
ATOM   1013  C  C     . LYS A 1 268 ? 92.849  91.702  65.540  1.00 70.77  ? 260 LYS A C     1 
ATOM   1014  O  O     . LYS A 1 268 ? 93.174  90.648  64.986  1.00 74.86  ? 260 LYS A O     1 
ATOM   1015  C  CB    . LYS A 1 268 ? 95.140  92.357  66.288  1.00 68.85  ? 260 LYS A CB    1 
ATOM   1016  C  CG    . LYS A 1 268 ? 96.190  93.444  66.444  1.00 70.55  ? 260 LYS A CG    1 
ATOM   1017  C  CD    . LYS A 1 268 ? 97.381  92.960  67.251  1.00 77.25  ? 260 LYS A CD    1 
ATOM   1018  C  CE    . LYS A 1 268 ? 98.379  94.082  67.479  1.00 79.03  ? 260 LYS A CE    1 
ATOM   1019  N  NZ    . LYS A 1 268 ? 99.543  93.635  68.291  1.00 76.96  ? 260 LYS A NZ    1 
ATOM   1020  N  N     . PHE A 1 269 ? 91.648  91.879  66.083  1.00 69.68  ? 261 PHE A N     1 
ATOM   1021  C  CA    . PHE A 1 269 ? 90.626  90.846  65.982  1.00 71.31  ? 261 PHE A CA    1 
ATOM   1022  C  C     . PHE A 1 269 ? 90.138  90.719  64.545  1.00 81.56  ? 261 PHE A C     1 
ATOM   1023  O  O     . PHE A 1 269 ? 89.950  91.717  63.844  1.00 84.13  ? 261 PHE A O     1 
ATOM   1024  C  CB    . PHE A 1 269 ? 89.452  91.165  66.907  1.00 72.98  ? 261 PHE A CB    1 
ATOM   1025  C  CG    . PHE A 1 269 ? 89.725  90.884  68.357  1.00 71.58  ? 261 PHE A CG    1 
ATOM   1026  C  CD1   . PHE A 1 269 ? 90.660  91.626  69.056  1.00 70.09  ? 261 PHE A CD1   1 
ATOM   1027  C  CD2   . PHE A 1 269 ? 89.036  89.887  69.023  1.00 74.21  ? 261 PHE A CD2   1 
ATOM   1028  C  CE1   . PHE A 1 269 ? 90.911  91.373  70.390  1.00 70.06  ? 261 PHE A CE1   1 
ATOM   1029  C  CE2   . PHE A 1 269 ? 89.280  89.629  70.358  1.00 72.94  ? 261 PHE A CE2   1 
ATOM   1030  C  CZ    . PHE A 1 269 ? 90.220  90.374  71.042  1.00 70.19  ? 261 PHE A CZ    1 
ATOM   1031  N  N     . LYS A 1 270 ? 89.934  89.479  64.106  1.00 85.16  ? 262 LYS A N     1 
ATOM   1032  C  CA    . LYS A 1 270 ? 89.443  89.202  62.766  1.00 81.37  ? 262 LYS A CA    1 
ATOM   1033  C  C     . LYS A 1 270 ? 88.417  88.081  62.831  1.00 83.86  ? 262 LYS A C     1 
ATOM   1034  O  O     . LYS A 1 270 ? 88.417  87.265  63.755  1.00 86.79  ? 262 LYS A O     1 
ATOM   1035  C  CB    . LYS A 1 270 ? 90.580  88.820  61.808  1.00 81.02  ? 262 LYS A CB    1 
ATOM   1036  C  CG    . LYS A 1 270 ? 91.573  89.935  61.536  1.00 80.25  ? 262 LYS A CG    1 
ATOM   1037  C  CD    . LYS A 1 270 ? 92.659  89.481  60.574  1.00 88.79  ? 262 LYS A CD    1 
ATOM   1038  C  CE    . LYS A 1 270 ? 93.652  90.596  60.294  1.00 90.47  ? 262 LYS A CE    1 
ATOM   1039  N  NZ    . LYS A 1 270 ? 94.719  90.166  59.349  1.00 95.93  ? 262 LYS A NZ    1 
ATOM   1040  N  N     . GLY A 1 271 ? 87.543  88.048  61.828  1.00 84.63  ? 263 GLY A N     1 
ATOM   1041  C  CA    . GLY A 1 271 ? 86.527  87.011  61.778  1.00 85.59  ? 263 GLY A CA    1 
ATOM   1042  C  C     . GLY A 1 271 ? 85.554  87.126  62.935  1.00 82.48  ? 263 GLY A C     1 
ATOM   1043  O  O     . GLY A 1 271 ? 85.142  88.222  63.329  1.00 84.18  ? 263 GLY A O     1 
ATOM   1044  N  N     . GLN A 1 272 ? 85.180  85.976  63.492  1.00 84.56  ? 264 GLN A N     1 
ATOM   1045  C  CA    . GLN A 1 272 ? 84.235  85.913  64.596  1.00 89.38  ? 264 GLN A CA    1 
ATOM   1046  C  C     . GLN A 1 272 ? 84.917  85.777  65.952  1.00 88.22  ? 264 GLN A C     1 
ATOM   1047  O  O     . GLN A 1 272 ? 84.237  85.542  66.955  1.00 89.65  ? 264 GLN A O     1 
ATOM   1048  C  CB    . GLN A 1 272 ? 83.254  84.759  64.385  1.00 92.52  ? 264 GLN A CB    1 
ATOM   1049  C  CG    . GLN A 1 272 ? 82.457  84.864  63.097  1.00 95.83  ? 264 GLN A CG    1 
ATOM   1050  C  CD    . GLN A 1 272 ? 81.305  83.881  63.042  1.00 107.25 ? 264 GLN A CD    1 
ATOM   1051  O  OE1   . GLN A 1 272 ? 80.857  83.376  64.071  1.00 107.51 ? 264 GLN A OE1   1 
ATOM   1052  N  NE2   . GLN A 1 272 ? 80.819  83.605  61.838  1.00 107.84 ? 264 GLN A NE2   1 
ATOM   1053  N  N     . GLN A 1 273 ? 86.241  85.912  66.004  1.00 87.82  ? 265 GLN A N     1 
ATOM   1054  C  CA    . GLN A 1 273 ? 86.952  85.881  67.276  1.00 85.65  ? 265 GLN A CA    1 
ATOM   1055  C  C     . GLN A 1 273 ? 86.547  87.085  68.116  1.00 84.53  ? 265 GLN A C     1 
ATOM   1056  O  O     . GLN A 1 273 ? 86.726  88.232  67.695  1.00 86.35  ? 265 GLN A O     1 
ATOM   1057  C  CB    . GLN A 1 273 ? 88.461  85.876  67.039  1.00 82.52  ? 265 GLN A CB    1 
ATOM   1058  C  CG    . GLN A 1 273 ? 88.981  84.642  66.326  1.00 82.24  ? 265 GLN A CG    1 
ATOM   1059  C  CD    . GLN A 1 273 ? 90.448  84.751  65.969  1.00 85.26  ? 265 GLN A CD    1 
ATOM   1060  O  OE1   . GLN A 1 273 ? 90.993  85.850  65.872  1.00 86.68  ? 265 GLN A OE1   1 
ATOM   1061  N  NE2   . GLN A 1 273 ? 91.097  83.610  65.773  1.00 88.25  ? 265 GLN A NE2   1 
ATOM   1062  N  N     . VAL A 1 274 ? 85.994  86.827  69.299  1.00 80.67  ? 266 VAL A N     1 
ATOM   1063  C  CA    . VAL A 1 274 ? 85.541  87.906  70.173  1.00 78.03  ? 266 VAL A CA    1 
ATOM   1064  C  C     . VAL A 1 274 ? 86.106  87.826  71.580  1.00 75.83  ? 266 VAL A C     1 
ATOM   1065  O  O     . VAL A 1 274 ? 86.189  88.862  72.263  1.00 75.70  ? 266 VAL A O     1 
ATOM   1066  C  CB    . VAL A 1 274 ? 83.998  87.944  70.221  1.00 78.58  ? 266 VAL A CB    1 
ATOM   1067  C  CG1   . VAL A 1 274 ? 83.441  88.400  68.887  1.00 82.73  ? 266 VAL A CG1   1 
ATOM   1068  C  CG2   . VAL A 1 274 ? 83.451  86.577  70.581  1.00 81.15  ? 266 VAL A CG2   1 
ATOM   1069  N  N     . LEU A 1 275 ? 86.515  86.658  72.070  1.00 73.48  ? 267 LEU A N     1 
ATOM   1070  C  CA    . LEU A 1 275 ? 87.035  86.511  73.425  1.00 66.67  ? 267 LEU A CA    1 
ATOM   1071  C  C     . LEU A 1 275 ? 88.555  86.455  73.350  1.00 67.26  ? 267 LEU A C     1 
ATOM   1072  O  O     . LEU A 1 275 ? 89.119  85.458  72.894  1.00 78.68  ? 267 LEU A O     1 
ATOM   1073  C  CB    . LEU A 1 275 ? 86.486  85.252  74.091  1.00 65.81  ? 267 LEU A CB    1 
ATOM   1074  C  CG    . LEU A 1 275 ? 85.069  84.793  73.749  1.00 73.00  ? 267 LEU A CG    1 
ATOM   1075  C  CD1   . LEU A 1 275 ? 84.770  83.478  74.448  1.00 77.01  ? 267 LEU A CD1   1 
ATOM   1076  C  CD2   . LEU A 1 275 ? 84.044  85.843  74.128  1.00 79.43  ? 267 LEU A CD2   1 
ATOM   1077  N  N     . GLY A 1 276 ? 89.216  87.516  73.799  1.00 62.31  ? 268 GLY A N     1 
ATOM   1078  C  CA    . GLY A 1 276 ? 90.665  87.517  73.820  1.00 64.13  ? 268 GLY A CA    1 
ATOM   1079  C  C     . GLY A 1 276 ? 91.198  86.839  75.064  1.00 63.90  ? 268 GLY A C     1 
ATOM   1080  O  O     . GLY A 1 276 ? 91.222  87.441  76.141  1.00 65.23  ? 268 GLY A O     1 
ATOM   1081  N  N     . LEU A 1 277 ? 91.633  85.589  74.933  1.00 67.20  ? 269 LEU A N     1 
ATOM   1082  C  CA    . LEU A 1 277 ? 92.006  84.784  76.085  1.00 65.99  ? 269 LEU A CA    1 
ATOM   1083  C  C     . LEU A 1 277 ? 93.428  84.268  75.931  1.00 68.88  ? 269 LEU A C     1 
ATOM   1084  O  O     . LEU A 1 277 ? 93.954  84.148  74.823  1.00 70.67  ? 269 LEU A O     1 
ATOM   1085  C  CB    . LEU A 1 277 ? 91.046  83.603  76.281  1.00 67.25  ? 269 LEU A CB    1 
ATOM   1086  C  CG    . LEU A 1 277 ? 89.590  83.956  76.569  1.00 62.32  ? 269 LEU A CG    1 
ATOM   1087  C  CD1   . LEU A 1 277 ? 88.804  82.718  76.959  1.00 67.26  ? 269 LEU A CD1   1 
ATOM   1088  C  CD2   . LEU A 1 277 ? 89.523  84.999  77.660  1.00 63.11  ? 269 LEU A CD2   1 
ATOM   1089  N  N     . VAL A 1 278 ? 94.044  83.961  77.069  1.00 73.61  ? 270 VAL A N     1 
ATOM   1090  C  CA    . VAL A 1 278 ? 95.391  83.409  77.129  1.00 77.33  ? 270 VAL A CA    1 
ATOM   1091  C  C     . VAL A 1 278 ? 95.279  81.936  77.493  1.00 81.01  ? 270 VAL A C     1 
ATOM   1092  O  O     . VAL A 1 278 ? 94.529  81.573  78.407  1.00 78.22  ? 270 VAL A O     1 
ATOM   1093  C  CB    . VAL A 1 278 ? 96.266  84.163  78.145  1.00 69.84  ? 270 VAL A CB    1 
ATOM   1094  C  CG1   . VAL A 1 278 ? 97.654  83.550  78.206  1.00 71.66  ? 270 VAL A CG1   1 
ATOM   1095  C  CG2   . VAL A 1 278 ? 96.347  85.636  77.785  1.00 67.47  ? 270 VAL A CG2   1 
ATOM   1096  N  N     . GLU A 1 279 ? 96.010  81.091  76.767  1.00 84.70  ? 271 GLU A N     1 
ATOM   1097  C  CA    . GLU A 1 279 ? 95.956  79.657  77.013  1.00 88.57  ? 271 GLU A CA    1 
ATOM   1098  C  C     . GLU A 1 279 ? 96.410  79.341  78.433  1.00 93.22  ? 271 GLU A C     1 
ATOM   1099  O  O     . GLU A 1 279 ? 97.364  79.933  78.945  1.00 93.05  ? 271 GLU A O     1 
ATOM   1100  C  CB    . GLU A 1 279 ? 96.825  78.911  76.001  1.00 90.66  ? 271 GLU A CB    1 
ATOM   1101  C  CG    . GLU A 1 279 ? 96.766  77.396  76.133  1.00 100.88 ? 271 GLU A CG    1 
ATOM   1102  C  CD    . GLU A 1 279 ? 97.645  76.684  75.125  1.00 110.44 ? 271 GLU A CD    1 
ATOM   1103  O  OE1   . GLU A 1 279 ? 98.322  77.372  74.332  1.00 111.48 ? 271 GLU A OE1   1 
ATOM   1104  O  OE2   . GLU A 1 279 ? 97.659  75.435  75.126  1.00 112.31 ? 271 GLU A OE2   1 
ATOM   1105  N  N     . ASN A 1 280 ? 95.707  78.408  79.071  1.00 94.95  ? 272 ASN A N     1 
ATOM   1106  C  CA    . ASN A 1 280 ? 96.034  78.021  80.436  1.00 90.44  ? 272 ASN A CA    1 
ATOM   1107  C  C     . ASN A 1 280 ? 97.448  77.458  80.503  1.00 99.26  ? 272 ASN A C     1 
ATOM   1108  O  O     . ASN A 1 280 ? 97.852  76.646  79.666  1.00 104.87 ? 272 ASN A O     1 
ATOM   1109  C  CB    . ASN A 1 280 ? 95.027  76.989  80.944  1.00 91.87  ? 272 ASN A CB    1 
ATOM   1110  C  CG    . ASN A 1 280 ? 95.074  76.815  82.448  1.00 96.46  ? 272 ASN A CG    1 
ATOM   1111  O  OD1   . ASN A 1 280 ? 96.075  77.123  83.093  1.00 100.62 ? 272 ASN A OD1   1 
ATOM   1112  N  ND2   . ASN A 1 280 ? 93.983  76.314  83.016  1.00 100.76 ? 272 ASN A ND2   1 
ATOM   1113  N  N     . GLN A 1 281 ? 98.202  77.896  81.509  1.00 98.01  ? 273 GLN A N     1 
ATOM   1114  C  CA    . GLN A 1 281 ? 99.589  77.488  81.680  1.00 97.06  ? 273 GLN A CA    1 
ATOM   1115  C  C     . GLN A 1 281 ? 99.747  76.298  82.618  1.00 99.84  ? 273 GLN A C     1 
ATOM   1116  O  O     . GLN A 1 281 ? 100.880 75.907  82.917  1.00 102.16 ? 273 GLN A O     1 
ATOM   1117  C  CB    . GLN A 1 281 ? 100.425 78.666  82.183  1.00 91.12  ? 273 GLN A CB    1 
ATOM   1118  C  CG    . GLN A 1 281 ? 100.448 79.846  81.229  1.00 90.37  ? 273 GLN A CG    1 
ATOM   1119  C  CD    . GLN A 1 281 ? 101.410 80.929  81.667  1.00 88.68  ? 273 GLN A CD    1 
ATOM   1120  O  OE1   . GLN A 1 281 ? 102.080 80.802  82.691  1.00 90.91  ? 273 GLN A OE1   1 
ATOM   1121  N  NE2   . GLN A 1 281 ? 101.485 82.003  80.891  1.00 84.84  ? 273 GLN A NE2   1 
ATOM   1122  N  N     . SER A 1 282 ? 98.648  75.718  83.084  1.00 101.91 ? 274 SER A N     1 
ATOM   1123  C  CA    . SER A 1 282 ? 98.675  74.545  83.943  1.00 104.39 ? 274 SER A CA    1 
ATOM   1124  C  C     . SER A 1 282 ? 98.144  73.334  83.187  1.00 108.77 ? 274 SER A C     1 
ATOM   1125  O  O     . SER A 1 282 ? 97.476  73.453  82.156  1.00 109.81 ? 274 SER A O     1 
ATOM   1126  C  CB    . SER A 1 282 ? 97.851  74.778  85.214  1.00 102.93 ? 274 SER A CB    1 
ATOM   1127  O  OG    . SER A 1 282 ? 96.468  74.846  84.918  1.00 102.13 ? 274 SER A OG    1 
ATOM   1128  N  N     . ASP A 1 283 ? 98.451  72.153  83.719  1.00 112.90 ? 275 ASP A N     1 
ATOM   1129  C  CA    . ASP A 1 283 ? 97.985  70.896  83.156  1.00 115.43 ? 275 ASP A CA    1 
ATOM   1130  C  C     . ASP A 1 283 ? 96.649  70.455  83.742  1.00 117.55 ? 275 ASP A C     1 
ATOM   1131  O  O     . ASP A 1 283 ? 96.341  69.257  83.730  1.00 118.42 ? 275 ASP A O     1 
ATOM   1132  C  CB    . ASP A 1 283 ? 99.037  69.805  83.362  1.00 117.12 ? 275 ASP A CB    1 
ATOM   1133  C  CG    . ASP A 1 283 ? 100.373 70.162  82.742  1.00 117.63 ? 275 ASP A CG    1 
ATOM   1134  O  OD1   . ASP A 1 283 ? 100.484 71.262  82.161  1.00 113.46 ? 275 ASP A OD1   1 
ATOM   1135  O  OD2   . ASP A 1 283 ? 101.311 69.342  82.835  1.00 117.55 ? 275 ASP A OD2   1 
ATOM   1136  N  N     . TRP A 1 284 ? 95.857  71.395  84.261  1.00 117.36 ? 276 TRP A N     1 
ATOM   1137  C  CA    . TRP A 1 284 ? 94.573  71.039  84.857  1.00 118.40 ? 276 TRP A CA    1 
ATOM   1138  C  C     . TRP A 1 284 ? 93.617  70.466  83.818  1.00 121.25 ? 276 TRP A C     1 
ATOM   1139  O  O     . TRP A 1 284 ? 92.918  69.481  84.084  1.00 123.83 ? 276 TRP A O     1 
ATOM   1140  C  CB    . TRP A 1 284 ? 93.958  72.260  85.540  1.00 115.21 ? 276 TRP A CB    1 
ATOM   1141  C  CG    . TRP A 1 284 ? 92.583  72.016  86.071  1.00 118.50 ? 276 TRP A CG    1 
ATOM   1142  C  CD1   . TRP A 1 284 ? 91.407  72.429  85.518  1.00 121.13 ? 276 TRP A CD1   1 
ATOM   1143  C  CD2   . TRP A 1 284 ? 92.236  71.292  87.258  1.00 120.17 ? 276 TRP A CD2   1 
ATOM   1144  N  NE1   . TRP A 1 284 ? 90.349  72.013  86.289  1.00 123.02 ? 276 TRP A NE1   1 
ATOM   1145  C  CE2   . TRP A 1 284 ? 90.832  71.312  87.363  1.00 122.36 ? 276 TRP A CE2   1 
ATOM   1146  C  CE3   . TRP A 1 284 ? 92.977  70.632  88.242  1.00 120.03 ? 276 TRP A CE3   1 
ATOM   1147  C  CZ2   . TRP A 1 284 ? 90.153  70.697  88.412  1.00 121.81 ? 276 TRP A CZ2   1 
ATOM   1148  C  CZ3   . TRP A 1 284 ? 92.301  70.022  89.283  1.00 119.86 ? 276 TRP A CZ3   1 
ATOM   1149  C  CH2   . TRP A 1 284 ? 90.904  70.059  89.360  1.00 120.81 ? 276 TRP A CH2   1 
ATOM   1150  N  N     . TYR A 1 285 ? 93.571  71.065  82.629  1.00 117.03 ? 277 TYR A N     1 
ATOM   1151  C  CA    . TYR A 1 285 ? 92.670  70.613  81.579  1.00 116.69 ? 277 TYR A CA    1 
ATOM   1152  C  C     . TYR A 1 285 ? 93.269  69.524  80.698  1.00 121.22 ? 277 TYR A C     1 
ATOM   1153  O  O     . TYR A 1 285 ? 92.554  68.973  79.854  1.00 121.44 ? 277 TYR A O     1 
ATOM   1154  C  CB    . TYR A 1 285 ? 92.242  71.796  80.702  1.00 117.08 ? 277 TYR A CB    1 
ATOM   1155  C  CG    . TYR A 1 285 ? 91.343  72.787  81.405  1.00 117.63 ? 277 TYR A CG    1 
ATOM   1156  C  CD1   . TYR A 1 285 ? 89.996  72.510  81.605  1.00 119.49 ? 277 TYR A CD1   1 
ATOM   1157  C  CD2   . TYR A 1 285 ? 91.837  74.001  81.863  1.00 115.19 ? 277 TYR A CD2   1 
ATOM   1158  C  CE1   . TYR A 1 285 ? 89.169  73.412  82.245  1.00 117.76 ? 277 TYR A CE1   1 
ATOM   1159  C  CE2   . TYR A 1 285 ? 91.016  74.910  82.505  1.00 112.49 ? 277 TYR A CE2   1 
ATOM   1160  C  CZ    . TYR A 1 285 ? 89.683  74.610  82.693  1.00 114.53 ? 277 TYR A CZ    1 
ATOM   1161  O  OH    . TYR A 1 285 ? 88.861  75.510  83.330  1.00 116.83 ? 277 TYR A OH    1 
ATOM   1162  N  N     . LEU A 1 286 ? 94.550  69.200  80.869  1.00 123.38 ? 278 LEU A N     1 
ATOM   1163  C  CA    . LEU A 1 286 ? 95.180  68.157  80.070  1.00 124.88 ? 278 LEU A CA    1 
ATOM   1164  C  C     . LEU A 1 286 ? 94.781  66.753  80.501  1.00 128.11 ? 278 LEU A C     1 
ATOM   1165  O  O     . LEU A 1 286 ? 95.054  65.798  79.766  1.00 130.60 ? 278 LEU A O     1 
ATOM   1166  C  CB    . LEU A 1 286 ? 96.704  68.296  80.128  1.00 124.17 ? 278 LEU A CB    1 
ATOM   1167  C  CG    . LEU A 1 286 ? 97.289  69.544  79.463  1.00 119.73 ? 278 LEU A CG    1 
ATOM   1168  C  CD1   . LEU A 1 286 ? 98.807  69.544  79.557  1.00 116.71 ? 278 LEU A CD1   1 
ATOM   1169  C  CD2   . LEU A 1 286 ? 96.840  69.635  78.015  1.00 114.12 ? 278 LEU A CD2   1 
ATOM   1170  N  N     . GLY A 1 287 ? 94.148  66.601  81.659  1.00 127.75 ? 279 GLY A N     1 
ATOM   1171  C  CA    . GLY A 1 287 ? 93.730  65.296  82.135  1.00 128.57 ? 279 GLY A CA    1 
ATOM   1172  C  C     . GLY A 1 287 ? 94.867  64.475  82.711  1.00 128.38 ? 279 GLY A C     1 
ATOM   1173  O  O     . GLY A 1 287 ? 95.705  63.954  81.975  1.00 128.06 ? 279 GLY A O     1 
ATOM   1174  N  N     . PRO A 1 295 ? 88.356  66.503  84.443  1.00 124.28 ? 287 PRO A N     1 
ATOM   1175  C  CA    . PRO A 1 295 ? 87.943  67.908  84.525  1.00 127.92 ? 287 PRO A CA    1 
ATOM   1176  C  C     . PRO A 1 295 ? 87.009  68.311  83.389  1.00 133.75 ? 287 PRO A C     1 
ATOM   1177  O  O     . PRO A 1 295 ? 86.621  67.466  82.582  1.00 135.42 ? 287 PRO A O     1 
ATOM   1178  C  CB    . PRO A 1 295 ? 89.270  68.664  84.432  1.00 123.36 ? 287 PRO A CB    1 
ATOM   1179  C  CG    . PRO A 1 295 ? 90.148  67.764  83.640  1.00 121.41 ? 287 PRO A CG    1 
ATOM   1180  C  CD    . PRO A 1 295 ? 89.768  66.366  84.045  1.00 123.29 ? 287 PRO A CD    1 
ATOM   1181  N  N     . TRP A 1 296 ? 86.653  69.590  83.337  1.00 133.57 ? 288 TRP A N     1 
ATOM   1182  C  CA    . TRP A 1 296 ? 85.780  70.074  82.280  1.00 131.92 ? 288 TRP A CA    1 
ATOM   1183  C  C     . TRP A 1 296 ? 86.495  70.011  80.932  1.00 129.87 ? 288 TRP A C     1 
ATOM   1184  O  O     . TRP A 1 296 ? 87.699  70.276  80.853  1.00 129.80 ? 288 TRP A O     1 
ATOM   1185  C  CB    . TRP A 1 296 ? 85.331  71.504  82.570  1.00 130.15 ? 288 TRP A CB    1 
ATOM   1186  C  CG    . TRP A 1 296 ? 84.143  71.578  83.475  1.00 134.54 ? 288 TRP A CG    1 
ATOM   1187  C  CD1   . TRP A 1 296 ? 84.011  71.000  84.703  1.00 137.12 ? 288 TRP A CD1   1 
ATOM   1188  C  CD2   . TRP A 1 296 ? 82.919  72.279  83.228  1.00 137.55 ? 288 TRP A CD2   1 
ATOM   1189  N  NE1   . TRP A 1 296 ? 82.778  71.291  85.233  1.00 139.46 ? 288 TRP A NE1   1 
ATOM   1190  C  CE2   . TRP A 1 296 ? 82.089  72.077  84.348  1.00 140.66 ? 288 TRP A CE2   1 
ATOM   1191  C  CE3   . TRP A 1 296 ? 82.445  73.057  82.168  1.00 135.82 ? 288 TRP A CE3   1 
ATOM   1192  C  CZ2   . TRP A 1 296 ? 80.812  72.623  84.437  1.00 141.74 ? 288 TRP A CZ2   1 
ATOM   1193  C  CZ3   . TRP A 1 296 ? 81.177  73.599  82.260  1.00 135.50 ? 288 TRP A CZ3   1 
ATOM   1194  C  CH2   . TRP A 1 296 ? 80.375  73.379  83.386  1.00 139.54 ? 288 TRP A CH2   1 
ATOM   1195  N  N     . PRO A 1 297 ? 85.787  69.656  79.860  1.00 128.19 ? 289 PRO A N     1 
ATOM   1196  C  CA    . PRO A 1 297 ? 86.422  69.606  78.539  1.00 125.52 ? 289 PRO A CA    1 
ATOM   1197  C  C     . PRO A 1 297 ? 86.933  70.973  78.112  1.00 123.18 ? 289 PRO A C     1 
ATOM   1198  O  O     . PRO A 1 297 ? 86.342  72.009  78.426  1.00 122.90 ? 289 PRO A O     1 
ATOM   1199  C  CB    . PRO A 1 297 ? 85.294  69.119  77.621  1.00 127.31 ? 289 PRO A CB    1 
ATOM   1200  C  CG    . PRO A 1 297 ? 84.328  68.435  78.532  1.00 129.32 ? 289 PRO A CG    1 
ATOM   1201  C  CD    . PRO A 1 297 ? 84.391  69.191  79.823  1.00 131.24 ? 289 PRO A CD    1 
ATOM   1202  N  N     . ALA A 1 298 ? 88.048  70.965  77.389  1.00 122.04 ? 290 ALA A N     1 
ATOM   1203  C  CA    . ALA A 1 298 ? 88.679  72.198  76.940  1.00 119.71 ? 290 ALA A CA    1 
ATOM   1204  C  C     . ALA A 1 298 ? 89.505  71.900  75.698  1.00 117.94 ? 290 ALA A C     1 
ATOM   1205  O  O     . ALA A 1 298 ? 89.788  70.744  75.377  1.00 117.25 ? 290 ALA A O     1 
ATOM   1206  C  CB    . ALA A 1 298 ? 89.546  72.815  78.041  1.00 119.87 ? 290 ALA A CB    1 
ATOM   1207  N  N     . LEU A 1 299 ? 89.886  72.966  75.000  1.00 115.77 ? 291 LEU A N     1 
ATOM   1208  C  CA    . LEU A 1 299 ? 90.707  72.861  73.802  1.00 114.95 ? 291 LEU A CA    1 
ATOM   1209  C  C     . LEU A 1 299 ? 92.174  72.990  74.191  1.00 113.33 ? 291 LEU A C     1 
ATOM   1210  O  O     . LEU A 1 299 ? 92.598  74.037  74.693  1.00 112.49 ? 291 LEU A O     1 
ATOM   1211  C  CB    . LEU A 1 299 ? 90.315  73.933  72.785  1.00 114.57 ? 291 LEU A CB    1 
ATOM   1212  C  CG    . LEU A 1 299 ? 91.033  73.928  71.434  1.00 113.68 ? 291 LEU A CG    1 
ATOM   1213  C  CD1   . LEU A 1 299 ? 90.049  74.234  70.319  1.00 111.25 ? 291 LEU A CD1   1 
ATOM   1214  C  CD2   . LEU A 1 299 ? 92.177  74.931  71.419  1.00 108.90 ? 291 LEU A CD2   1 
ATOM   1215  N  N     . GLY A 1 300 ? 92.946  71.934  73.948  1.00 113.10 ? 292 GLY A N     1 
ATOM   1216  C  CA    . GLY A 1 300 ? 94.344  71.941  74.347  1.00 112.62 ? 292 GLY A CA    1 
ATOM   1217  C  C     . GLY A 1 300 ? 94.474  72.038  75.853  1.00 113.45 ? 292 GLY A C     1 
ATOM   1218  O  O     . GLY A 1 300 ? 93.849  71.282  76.605  1.00 114.67 ? 292 GLY A O     1 
ATOM   1219  N  N     . ARG A 1 301 ? 95.297  72.982  76.310  1.00 111.52 ? 293 ARG A N     1 
ATOM   1220  C  CA    . ARG A 1 301 ? 95.445  73.227  77.738  1.00 108.70 ? 293 ARG A CA    1 
ATOM   1221  C  C     . ARG A 1 301 ? 94.297  74.037  78.322  1.00 108.68 ? 293 ARG A C     1 
ATOM   1222  O  O     . ARG A 1 301 ? 94.211  74.162  79.548  1.00 108.62 ? 293 ARG A O     1 
ATOM   1223  C  CB    . ARG A 1 301 ? 96.765  73.952  78.019  1.00 106.71 ? 293 ARG A CB    1 
ATOM   1224  C  CG    . ARG A 1 301 ? 98.007  73.125  77.745  1.00 112.78 ? 293 ARG A CG    1 
ATOM   1225  C  CD    . ARG A 1 301 ? 99.247  73.818  78.284  1.00 115.91 ? 293 ARG A CD    1 
ATOM   1226  N  NE    . ARG A 1 301 ? 100.444 73.000  78.134  1.00 120.33 ? 293 ARG A NE    1 
ATOM   1227  C  CZ    . ARG A 1 301 ? 101.294 73.095  77.120  1.00 124.74 ? 293 ARG A CZ    1 
ATOM   1228  N  NH1   . ARG A 1 301 ? 101.110 73.968  76.143  1.00 125.84 ? 293 ARG A NH1   1 
ATOM   1229  N  NH2   . ARG A 1 301 ? 102.356 72.295  77.087  1.00 123.01 ? 293 ARG A NH2   1 
ATOM   1230  N  N     . GLY A 1 302 ? 93.417  74.578  77.485  1.00 108.51 ? 294 GLY A N     1 
ATOM   1231  C  CA    . GLY A 1 302 ? 92.373  75.469  77.939  1.00 104.89 ? 294 GLY A CA    1 
ATOM   1232  C  C     . GLY A 1 302 ? 92.842  76.911  78.002  1.00 98.18  ? 294 GLY A C     1 
ATOM   1233  O  O     . GLY A 1 302 ? 94.018  77.233  77.819  1.00 96.79  ? 294 GLY A O     1 
ATOM   1234  N  N     . TYR A 1 303 ? 91.891  77.800  78.272  1.00 92.49  ? 295 TYR A N     1 
ATOM   1235  C  CA    . TYR A 1 303 ? 92.164  79.225  78.358  1.00 84.39  ? 295 TYR A CA    1 
ATOM   1236  C  C     . TYR A 1 303 ? 91.847  79.733  79.757  1.00 83.20  ? 295 TYR A C     1 
ATOM   1237  O  O     . TYR A 1 303 ? 90.924  79.250  80.419  1.00 86.48  ? 295 TYR A O     1 
ATOM   1238  C  CB    . TYR A 1 303 ? 91.361  80.010  77.317  1.00 78.40  ? 295 TYR A CB    1 
ATOM   1239  C  CG    . TYR A 1 303 ? 91.905  79.881  75.913  1.00 81.59  ? 295 TYR A CG    1 
ATOM   1240  C  CD1   . TYR A 1 303 ? 92.872  80.758  75.442  1.00 82.82  ? 295 TYR A CD1   1 
ATOM   1241  C  CD2   . TYR A 1 303 ? 91.457  78.881  75.060  1.00 86.03  ? 295 TYR A CD2   1 
ATOM   1242  C  CE1   . TYR A 1 303 ? 93.376  80.647  74.162  1.00 84.38  ? 295 TYR A CE1   1 
ATOM   1243  C  CE2   . TYR A 1 303 ? 91.956  78.762  73.777  1.00 85.04  ? 295 TYR A CE2   1 
ATOM   1244  C  CZ    . TYR A 1 303 ? 92.916  79.649  73.334  1.00 83.56  ? 295 TYR A CZ    1 
ATOM   1245  O  OH    . TYR A 1 303 ? 93.419  79.539  72.059  1.00 84.59  ? 295 TYR A OH    1 
ATOM   1246  N  N     . ASN A 1 304 ? 92.626  80.714  80.200  1.00 80.10  ? 296 ASN A N     1 
ATOM   1247  C  CA    . ASN A 1 304 ? 92.512  81.268  81.542  1.00 77.32  ? 296 ASN A CA    1 
ATOM   1248  C  C     . ASN A 1 304 ? 91.677  82.540  81.507  1.00 72.09  ? 296 ASN A C     1 
ATOM   1249  O  O     . ASN A 1 304 ? 91.926  83.431  80.688  1.00 70.35  ? 296 ASN A O     1 
ATOM   1250  C  CB    . ASN A 1 304 ? 93.896  81.556  82.124  1.00 75.00  ? 296 ASN A CB    1 
ATOM   1251  C  CG    . ASN A 1 304 ? 93.831  82.129  83.521  1.00 71.57  ? 296 ASN A CG    1 
ATOM   1252  O  OD1   . ASN A 1 304 ? 93.950  83.338  83.712  1.00 70.91  ? 296 ASN A OD1   1 
ATOM   1253  N  ND2   . ASN A 1 304 ? 93.643  81.263  84.508  1.00 72.95  ? 296 ASN A ND2   1 
ATOM   1254  N  N     . THR A 1 305 ? 90.694  82.623  82.402  1.00 71.19  ? 297 THR A N     1 
ATOM   1255  C  CA    . THR A 1 305 ? 89.785  83.757  82.467  1.00 68.07  ? 297 THR A CA    1 
ATOM   1256  C  C     . THR A 1 305 ? 90.287  84.866  83.384  1.00 66.91  ? 297 THR A C     1 
ATOM   1257  O  O     . THR A 1 305 ? 89.503  85.741  83.768  1.00 70.15  ? 297 THR A O     1 
ATOM   1258  C  CB    . THR A 1 305 ? 88.398  83.294  82.916  1.00 77.68  ? 297 THR A CB    1 
ATOM   1259  O  OG1   . THR A 1 305 ? 88.495  82.667  84.200  1.00 86.74  ? 297 THR A OG1   1 
ATOM   1260  C  CG2   . THR A 1 305 ? 87.826  82.303  81.920  1.00 85.34  ? 297 THR A CG2   1 
ATOM   1261  N  N     . GLY A 1 306 ? 91.569  84.844  83.751  1.00 63.36  ? 298 GLY A N     1 
ATOM   1262  C  CA    . GLY A 1 306 ? 92.111  85.924  84.558  1.00 55.17  ? 298 GLY A CA    1 
ATOM   1263  C  C     . GLY A 1 306 ? 92.069  87.259  83.842  1.00 57.59  ? 298 GLY A C     1 
ATOM   1264  O  O     . GLY A 1 306 ? 91.756  88.288  84.445  1.00 60.92  ? 298 GLY A O     1 
ATOM   1265  N  N     . VAL A 1 307 ? 92.389  87.263  82.551  1.00 59.36  ? 299 VAL A N     1 
ATOM   1266  C  CA    . VAL A 1 307 ? 92.296  88.449  81.709  1.00 49.73  ? 299 VAL A CA    1 
ATOM   1267  C  C     . VAL A 1 307 ? 91.488  88.083  80.475  1.00 52.84  ? 299 VAL A C     1 
ATOM   1268  O  O     . VAL A 1 307 ? 91.821  87.122  79.774  1.00 56.40  ? 299 VAL A O     1 
ATOM   1269  C  CB    . VAL A 1 307 ? 93.683  88.985  81.309  1.00 46.96  ? 299 VAL A CB    1 
ATOM   1270  C  CG1   . VAL A 1 307 ? 93.541  90.143  80.340  1.00 49.17  ? 299 VAL A CG1   1 
ATOM   1271  C  CG2   . VAL A 1 307 ? 94.461  89.412  82.539  1.00 50.60  ? 299 VAL A CG2   1 
ATOM   1272  N  N     . ILE A 1 308 ? 90.428  88.844  80.210  1.00 50.55  ? 300 ILE A N     1 
ATOM   1273  C  CA    . ILE A 1 308 ? 89.532  88.588  79.090  1.00 48.47  ? 300 ILE A CA    1 
ATOM   1274  C  C     . ILE A 1 308 ? 89.390  89.869  78.284  1.00 51.68  ? 300 ILE A C     1 
ATOM   1275  O  O     . ILE A 1 308 ? 89.342  90.963  78.852  1.00 57.39  ? 300 ILE A O     1 
ATOM   1276  C  CB    . ILE A 1 308 ? 88.149  88.097  79.571  1.00 46.42  ? 300 ILE A CB    1 
ATOM   1277  C  CG1   . ILE A 1 308 ? 88.295  86.881  80.486  1.00 50.81  ? 300 ILE A CG1   1 
ATOM   1278  C  CG2   . ILE A 1 308 ? 87.252  87.764  78.393  1.00 48.47  ? 300 ILE A CG2   1 
ATOM   1279  C  CD1   . ILE A 1 308 ? 86.977  86.280  80.908  1.00 56.56  ? 300 ILE A CD1   1 
ATOM   1280  N  N     . LEU A 1 309 ? 89.337  89.738  76.963  1.00 51.21  ? 301 LEU A N     1 
ATOM   1281  C  CA    . LEU A 1 309 ? 88.976  90.839  76.078  1.00 54.59  ? 301 LEU A CA    1 
ATOM   1282  C  C     . LEU A 1 309 ? 87.637  90.504  75.439  1.00 60.01  ? 301 LEU A C     1 
ATOM   1283  O  O     . LEU A 1 309 ? 87.498  89.454  74.804  1.00 66.15  ? 301 LEU A O     1 
ATOM   1284  C  CB    . LEU A 1 309 ? 90.044  91.070  75.010  1.00 59.10  ? 301 LEU A CB    1 
ATOM   1285  C  CG    . LEU A 1 309 ? 91.442  91.445  75.498  1.00 54.69  ? 301 LEU A CG    1 
ATOM   1286  C  CD1   . LEU A 1 309 ? 92.288  91.950  74.342  1.00 59.37  ? 301 LEU A CD1   1 
ATOM   1287  C  CD2   . LEU A 1 309 ? 91.370  92.481  76.599  1.00 48.35  ? 301 LEU A CD2   1 
ATOM   1288  N  N     . LEU A 1 310 ? 86.654  91.386  75.607  1.00 61.40  ? 302 LEU A N     1 
ATOM   1289  C  CA    . LEU A 1 310 ? 85.300  91.140  75.133  1.00 63.90  ? 302 LEU A CA    1 
ATOM   1290  C  C     . LEU A 1 310 ? 84.886  92.223  74.151  1.00 70.32  ? 302 LEU A C     1 
ATOM   1291  O  O     . LEU A 1 310 ? 85.158  93.407  74.374  1.00 72.09  ? 302 LEU A O     1 
ATOM   1292  C  CB    . LEU A 1 310 ? 84.302  91.090  76.292  1.00 62.03  ? 302 LEU A CB    1 
ATOM   1293  C  CG    . LEU A 1 310 ? 84.350  89.877  77.219  1.00 66.09  ? 302 LEU A CG    1 
ATOM   1294  C  CD1   . LEU A 1 310 ? 83.225  89.943  78.237  1.00 71.01  ? 302 LEU A CD1   1 
ATOM   1295  C  CD2   . LEU A 1 310 ? 84.263  88.601  76.412  1.00 67.92  ? 302 LEU A CD2   1 
ATOM   1296  N  N     . LEU A 1 311 ? 84.234  91.809  73.068  1.00 76.90  ? 303 LEU A N     1 
ATOM   1297  C  CA    . LEU A 1 311 ? 83.534  92.714  72.162  1.00 80.02  ? 303 LEU A CA    1 
ATOM   1298  C  C     . LEU A 1 311 ? 82.047  92.541  72.449  1.00 90.25  ? 303 LEU A C     1 
ATOM   1299  O  O     . LEU A 1 311 ? 81.420  91.586  71.983  1.00 93.33  ? 303 LEU A O     1 
ATOM   1300  C  CB    . LEU A 1 311 ? 83.873  92.420  70.705  1.00 79.62  ? 303 LEU A CB    1 
ATOM   1301  C  CG    . LEU A 1 311 ? 85.257  92.844  70.206  1.00 76.91  ? 303 LEU A CG    1 
ATOM   1302  C  CD1   . LEU A 1 311 ? 86.332  91.861  70.640  1.00 76.02  ? 303 LEU A CD1   1 
ATOM   1303  C  CD2   . LEU A 1 311 ? 85.258  93.005  68.696  1.00 80.17  ? 303 LEU A CD2   1 
ATOM   1304  N  N     . LEU A 1 312 ? 81.488  93.468  73.231  1.00 88.44  ? 304 LEU A N     1 
ATOM   1305  C  CA    . LEU A 1 312 ? 80.122  93.307  73.721  1.00 89.20  ? 304 LEU A CA    1 
ATOM   1306  C  C     . LEU A 1 312 ? 79.110  93.322  72.583  1.00 98.33  ? 304 LEU A C     1 
ATOM   1307  O  O     . LEU A 1 312 ? 78.128  92.570  72.609  1.00 102.26 ? 304 LEU A O     1 
ATOM   1308  C  CB    . LEU A 1 312 ? 79.801  94.402  74.737  1.00 84.70  ? 304 LEU A CB    1 
ATOM   1309  C  CG    . LEU A 1 312 ? 80.645  94.404  76.010  1.00 82.19  ? 304 LEU A CG    1 
ATOM   1310  C  CD1   . LEU A 1 312 ? 80.235  95.551  76.918  1.00 83.45  ? 304 LEU A CD1   1 
ATOM   1311  C  CD2   . LEU A 1 312 ? 80.519  93.075  76.733  1.00 82.92  ? 304 LEU A CD2   1 
ATOM   1312  N  N     . ASP A 1 313 ? 79.323  94.179  71.584  1.00 97.72  ? 305 ASP A N     1 
ATOM   1313  C  CA    . ASP A 1 313 ? 78.368  94.291  70.486  1.00 98.06  ? 305 ASP A CA    1 
ATOM   1314  C  C     . ASP A 1 313 ? 78.235  92.971  69.734  1.00 104.74 ? 305 ASP A C     1 
ATOM   1315  O  O     . ASP A 1 313 ? 77.121  92.510  69.458  1.00 109.50 ? 305 ASP A O     1 
ATOM   1316  C  CB    . ASP A 1 313 ? 78.793  95.415  69.541  1.00 96.87  ? 305 ASP A CB    1 
ATOM   1317  C  CG    . ASP A 1 313 ? 80.253  95.321  69.144  1.00 96.84  ? 305 ASP A CG    1 
ATOM   1318  O  OD1   . ASP A 1 313 ? 81.049  94.774  69.936  1.00 95.06  ? 305 ASP A OD1   1 
ATOM   1319  O  OD2   . ASP A 1 313 ? 80.604  95.792  68.043  1.00 97.78  ? 305 ASP A OD2   1 
ATOM   1320  N  N     . LYS A 1 314 ? 79.364  92.339  69.411  1.00 100.67 ? 306 LYS A N     1 
ATOM   1321  C  CA    . LYS A 1 314 ? 79.315  91.084  68.668  1.00 99.15  ? 306 LYS A CA    1 
ATOM   1322  C  C     . LYS A 1 314 ? 78.734  89.958  69.514  1.00 102.91 ? 306 LYS A C     1 
ATOM   1323  O  O     . LYS A 1 314 ? 78.010  89.100  68.998  1.00 107.61 ? 306 LYS A O     1 
ATOM   1324  C  CB    . LYS A 1 314 ? 80.709  90.721  68.160  1.00 92.47  ? 306 LYS A CB    1 
ATOM   1325  C  CG    . LYS A 1 314 ? 81.278  91.727  67.173  1.00 94.17  ? 306 LYS A CG    1 
ATOM   1326  C  CD    . LYS A 1 314 ? 82.614  91.268  66.615  1.00 96.36  ? 306 LYS A CD    1 
ATOM   1327  C  CE    . LYS A 1 314 ? 83.168  92.275  65.620  1.00 95.66  ? 306 LYS A CE    1 
ATOM   1328  N  NZ    . LYS A 1 314 ? 84.473  91.835  65.054  1.00 91.26  ? 306 LYS A NZ    1 
ATOM   1329  N  N     . LEU A 1 315 ? 79.041  89.941  70.813  1.00 100.68 ? 307 LEU A N     1 
ATOM   1330  C  CA    . LEU A 1 315 ? 78.455  88.934  71.693  1.00 102.28 ? 307 LEU A CA    1 
ATOM   1331  C  C     . LEU A 1 315 ? 76.942  89.082  71.767  1.00 107.61 ? 307 LEU A C     1 
ATOM   1332  O  O     . LEU A 1 315 ? 76.211  88.085  71.755  1.00 110.10 ? 307 LEU A O     1 
ATOM   1333  C  CB    . LEU A 1 315 ? 79.069  89.030  73.089  1.00 97.80  ? 307 LEU A CB    1 
ATOM   1334  C  CG    . LEU A 1 315 ? 80.508  88.542  73.239  1.00 97.71  ? 307 LEU A CG    1 
ATOM   1335  C  CD1   . LEU A 1 315 ? 80.989  88.736  74.664  1.00 92.88  ? 307 LEU A CD1   1 
ATOM   1336  C  CD2   . LEU A 1 315 ? 80.607  87.084  72.836  1.00 100.93 ? 307 LEU A CD2   1 
ATOM   1337  N  N     . ARG A 1 316 ? 76.455  90.322  71.852  1.00 108.12 ? 308 ARG A N     1 
ATOM   1338  C  CA    . ARG A 1 316 ? 75.014  90.551  71.879  1.00 106.76 ? 308 ARG A CA    1 
ATOM   1339  C  C     . ARG A 1 316 ? 74.369  90.181  70.550  1.00 113.44 ? 308 ARG A C     1 
ATOM   1340  O  O     . ARG A 1 316 ? 73.251  89.653  70.522  1.00 115.40 ? 308 ARG A O     1 
ATOM   1341  C  CB    . ARG A 1 316 ? 74.726  92.009  72.237  1.00 101.83 ? 308 ARG A CB    1 
ATOM   1342  C  CG    . ARG A 1 316 ? 75.067  92.363  73.675  1.00 99.34  ? 308 ARG A CG    1 
ATOM   1343  C  CD    . ARG A 1 316 ? 75.347  93.847  73.830  1.00 94.63  ? 308 ARG A CD    1 
ATOM   1344  N  NE    . ARG A 1 316 ? 75.688  94.194  75.204  1.00 93.99  ? 308 ARG A NE    1 
ATOM   1345  C  CZ    . ARG A 1 316 ? 76.264  95.331  75.566  1.00 91.76  ? 308 ARG A CZ    1 
ATOM   1346  N  NH1   . ARG A 1 316 ? 76.599  96.250  74.676  1.00 92.78  ? 308 ARG A NH1   1 
ATOM   1347  N  NH2   . ARG A 1 316 ? 76.516  95.550  76.854  1.00 86.85  ? 308 ARG A NH2   1 
ATOM   1348  N  N     . LYS A 1 317 ? 75.056  90.451  69.437  1.00 115.29 ? 309 LYS A N     1 
ATOM   1349  C  CA    . LYS A 1 317 ? 74.514  90.084  68.132  1.00 112.99 ? 309 LYS A CA    1 
ATOM   1350  C  C     . LYS A 1 317 ? 74.444  88.572  67.953  1.00 113.09 ? 309 LYS A C     1 
ATOM   1351  O  O     . LYS A 1 317 ? 73.574  88.077  67.229  1.00 115.04 ? 309 LYS A O     1 
ATOM   1352  C  CB    . LYS A 1 317 ? 75.352  90.710  67.018  1.00 109.12 ? 309 LYS A CB    1 
ATOM   1353  C  CG    . LYS A 1 317 ? 75.239  92.222  66.935  1.00 109.63 ? 309 LYS A CG    1 
ATOM   1354  C  CD    . LYS A 1 317 ? 76.187  92.789  65.893  1.00 110.16 ? 309 LYS A CD    1 
ATOM   1355  C  CE    . LYS A 1 317 ? 76.116  94.306  65.854  1.00 113.26 ? 309 LYS A CE    1 
ATOM   1356  N  NZ    . LYS A 1 317 ? 77.062  94.879  64.857  1.00 116.10 ? 309 LYS A NZ    1 
ATOM   1357  N  N     . MET A 1 318 ? 75.340  87.828  68.597  1.00 113.12 ? 310 MET A N     1 
ATOM   1358  C  CA    . MET A 1 318 ? 75.388  86.379  68.458  1.00 114.51 ? 310 MET A CA    1 
ATOM   1359  C  C     . MET A 1 318 ? 74.620  85.644  69.549  1.00 114.50 ? 310 MET A C     1 
ATOM   1360  O  O     . MET A 1 318 ? 74.666  84.410  69.588  1.00 112.95 ? 310 MET A O     1 
ATOM   1361  C  CB    . MET A 1 318 ? 76.843  85.898  68.448  1.00 115.68 ? 310 MET A CB    1 
ATOM   1362  C  CG    . MET A 1 318 ? 77.660  86.425  67.281  1.00 117.78 ? 310 MET A CG    1 
ATOM   1363  S  SD    . MET A 1 318 ? 79.303  85.691  67.205  1.00 126.35 ? 310 MET A SD    1 
ATOM   1364  C  CE    . MET A 1 318 ? 78.887  83.971  66.931  1.00 121.96 ? 310 MET A CE    1 
ATOM   1365  N  N     . LYS A 1 319 ? 73.924  86.366  70.429  1.00 116.57 ? 311 LYS A N     1 
ATOM   1366  C  CA    . LYS A 1 319 ? 73.160  85.772  71.526  1.00 120.76 ? 311 LYS A CA    1 
ATOM   1367  C  C     . LYS A 1 319 ? 74.056  84.894  72.403  1.00 125.66 ? 311 LYS A C     1 
ATOM   1368  O  O     . LYS A 1 319 ? 73.872  83.681  72.518  1.00 127.75 ? 311 LYS A O     1 
ATOM   1369  C  CB    . LYS A 1 319 ? 71.957  84.984  70.996  1.00 119.83 ? 311 LYS A CB    1 
ATOM   1370  C  CG    . LYS A 1 319 ? 70.932  85.837  70.267  1.00 120.40 ? 311 LYS A CG    1 
ATOM   1371  C  CD    . LYS A 1 319 ? 69.721  85.016  69.856  1.00 123.22 ? 311 LYS A CD    1 
ATOM   1372  C  CE    . LYS A 1 319 ? 68.669  85.883  69.185  1.00 122.35 ? 311 LYS A CE    1 
ATOM   1373  N  NZ    . LYS A 1 319 ? 67.463  85.098  68.805  1.00 122.59 ? 311 LYS A NZ    1 
ATOM   1374  N  N     . TRP A 1 320 ? 75.047  85.544  73.021  1.00 122.63 ? 312 TRP A N     1 
ATOM   1375  C  CA    . TRP A 1 320 ? 75.994  84.826  73.867  1.00 119.87 ? 312 TRP A CA    1 
ATOM   1376  C  C     . TRP A 1 320 ? 75.313  84.213  75.083  1.00 122.68 ? 312 TRP A C     1 
ATOM   1377  O  O     . TRP A 1 320 ? 75.740  83.155  75.565  1.00 125.81 ? 312 TRP A O     1 
ATOM   1378  C  CB    . TRP A 1 320 ? 77.118  85.766  74.305  1.00 112.84 ? 312 TRP A CB    1 
ATOM   1379  C  CG    . TRP A 1 320 ? 78.010  85.188  75.359  1.00 115.59 ? 312 TRP A CG    1 
ATOM   1380  C  CD1   . TRP A 1 320 ? 77.896  85.352  76.709  1.00 114.21 ? 312 TRP A CD1   1 
ATOM   1381  C  CD2   . TRP A 1 320 ? 79.153  84.350  75.152  1.00 114.53 ? 312 TRP A CD2   1 
ATOM   1382  N  NE1   . TRP A 1 320 ? 78.897  84.669  77.355  1.00 113.25 ? 312 TRP A NE1   1 
ATOM   1383  C  CE2   . TRP A 1 320 ? 79.682  84.046  76.422  1.00 113.31 ? 312 TRP A CE2   1 
ATOM   1384  C  CE3   . TRP A 1 320 ? 79.780  83.828  74.018  1.00 109.95 ? 312 TRP A CE3   1 
ATOM   1385  C  CZ2   . TRP A 1 320 ? 80.808  83.245  76.588  1.00 108.54 ? 312 TRP A CZ2   1 
ATOM   1386  C  CZ3   . TRP A 1 320 ? 80.898  83.034  74.185  1.00 110.04 ? 312 TRP A CZ3   1 
ATOM   1387  C  CH2   . TRP A 1 320 ? 81.400  82.749  75.460  1.00 107.54 ? 312 TRP A CH2   1 
ATOM   1388  N  N     . GLU A 1 321 ? 74.262  84.860  75.594  1.00 121.17 ? 313 GLU A N     1 
ATOM   1389  C  CA    . GLU A 1 321 ? 73.582  84.357  76.783  1.00 122.86 ? 313 GLU A CA    1 
ATOM   1390  C  C     . GLU A 1 321 ? 73.043  82.951  76.554  1.00 126.15 ? 313 GLU A C     1 
ATOM   1391  O  O     . GLU A 1 321 ? 73.325  82.030  77.331  1.00 126.59 ? 313 GLU A O     1 
ATOM   1392  C  CB    . GLU A 1 321 ? 72.453  85.308  77.182  1.00 121.34 ? 313 GLU A CB    1 
ATOM   1393  C  CG    . GLU A 1 321 ? 72.918  86.699  77.584  1.00 122.73 ? 313 GLU A CG    1 
ATOM   1394  C  CD    . GLU A 1 321 ? 73.622  86.719  78.928  1.00 120.77 ? 313 GLU A CD    1 
ATOM   1395  O  OE1   . GLU A 1 321 ? 73.442  85.762  79.712  1.00 121.40 ? 313 GLU A OE1   1 
ATOM   1396  O  OE2   . GLU A 1 321 ? 74.355  87.692  79.201  1.00 113.98 ? 313 GLU A OE2   1 
ATOM   1397  N  N     . GLN A 1 322 ? 72.278  82.765  75.476  1.00 127.61 ? 314 GLN A N     1 
ATOM   1398  C  CA    . GLN A 1 322 ? 71.710  81.454  75.183  1.00 127.71 ? 314 GLN A CA    1 
ATOM   1399  C  C     . GLN A 1 322 ? 72.803  80.427  74.917  1.00 130.59 ? 314 GLN A C     1 
ATOM   1400  O  O     . GLN A 1 322 ? 72.709  79.279  75.366  1.00 133.50 ? 314 GLN A O     1 
ATOM   1401  C  CB    . GLN A 1 322 ? 70.763  81.552  73.988  1.00 125.88 ? 314 GLN A CB    1 
ATOM   1402  C  CG    . GLN A 1 322 ? 69.699  82.628  74.129  1.00 127.58 ? 314 GLN A CG    1 
ATOM   1403  C  CD    . GLN A 1 322 ? 68.862  82.787  72.876  1.00 127.84 ? 314 GLN A CD    1 
ATOM   1404  O  OE1   . GLN A 1 322 ? 69.027  82.046  71.907  1.00 129.52 ? 314 GLN A OE1   1 
ATOM   1405  N  NE2   . GLN A 1 322 ? 67.958  83.760  72.888  1.00 125.36 ? 314 GLN A NE2   1 
ATOM   1406  N  N     . MET A 1 323 ? 73.848  80.827  74.188  1.00 130.00 ? 315 MET A N     1 
ATOM   1407  C  CA    . MET A 1 323 ? 74.935  79.906  73.871  1.00 130.55 ? 315 MET A CA    1 
ATOM   1408  C  C     . MET A 1 323 ? 75.594  79.375  75.138  1.00 132.16 ? 315 MET A C     1 
ATOM   1409  O  O     . MET A 1 323 ? 75.715  78.156  75.326  1.00 133.18 ? 315 MET A O     1 
ATOM   1410  C  CB    . MET A 1 323 ? 75.965  80.605  72.984  1.00 125.85 ? 315 MET A CB    1 
ATOM   1411  C  CG    . MET A 1 323 ? 77.176  79.754  72.644  1.00 126.25 ? 315 MET A CG    1 
ATOM   1412  S  SD    . MET A 1 323 ? 78.544  80.724  71.980  1.00 124.86 ? 315 MET A SD    1 
ATOM   1413  C  CE    . MET A 1 323 ? 77.733  81.590  70.639  1.00 122.99 ? 315 MET A CE    1 
ATOM   1414  N  N     . TRP A 1 324 ? 76.012  80.278  76.031  1.00 129.31 ? 316 TRP A N     1 
ATOM   1415  C  CA    . TRP A 1 324 ? 76.696  79.818  77.233  1.00 127.44 ? 316 TRP A CA    1 
ATOM   1416  C  C     . TRP A 1 324 ? 75.744  79.088  78.170  1.00 131.93 ? 316 TRP A C     1 
ATOM   1417  O  O     . TRP A 1 324 ? 76.159  78.137  78.838  1.00 134.55 ? 316 TRP A O     1 
ATOM   1418  C  CB    . TRP A 1 324 ? 77.395  80.979  77.952  1.00 123.72 ? 316 TRP A CB    1 
ATOM   1419  C  CG    . TRP A 1 324 ? 76.536  81.799  78.873  1.00 122.96 ? 316 TRP A CG    1 
ATOM   1420  C  CD1   . TRP A 1 324 ? 76.013  83.029  78.617  1.00 122.22 ? 316 TRP A CD1   1 
ATOM   1421  C  CD2   . TRP A 1 324 ? 76.129  81.462  80.208  1.00 124.16 ? 316 TRP A CD2   1 
ATOM   1422  N  NE1   . TRP A 1 324 ? 75.291  83.474  79.696  1.00 124.17 ? 316 TRP A NE1   1 
ATOM   1423  C  CE2   . TRP A 1 324 ? 75.346  82.530  80.687  1.00 124.50 ? 316 TRP A CE2   1 
ATOM   1424  C  CE3   . TRP A 1 324 ? 76.341  80.358  81.040  1.00 127.13 ? 316 TRP A CE3   1 
ATOM   1425  C  CZ2   . TRP A 1 324 ? 74.777  82.528  81.958  1.00 126.10 ? 316 TRP A CZ2   1 
ATOM   1426  C  CZ3   . TRP A 1 324 ? 75.773  80.356  82.300  1.00 130.58 ? 316 TRP A CZ3   1 
ATOM   1427  C  CH2   . TRP A 1 324 ? 75.001  81.434  82.747  1.00 128.97 ? 316 TRP A CH2   1 
ATOM   1428  N  N     . ARG A 1 325 ? 74.472  79.496  78.232  1.00 133.36 ? 317 ARG A N     1 
ATOM   1429  C  CA    . ARG A 1 325 ? 73.520  78.785  79.080  1.00 135.07 ? 317 ARG A CA    1 
ATOM   1430  C  C     . ARG A 1 325 ? 73.339  77.347  78.612  1.00 138.21 ? 317 ARG A C     1 
ATOM   1431  O  O     . ARG A 1 325 ? 73.373  76.410  79.419  1.00 138.98 ? 317 ARG A O     1 
ATOM   1432  C  CB    . ARG A 1 325 ? 72.179  79.518  79.102  1.00 133.65 ? 317 ARG A CB    1 
ATOM   1433  C  CG    . ARG A 1 325 ? 72.155  80.752  79.988  1.00 131.51 ? 317 ARG A CG    1 
ATOM   1434  C  CD    . ARG A 1 325 ? 70.781  81.400  79.990  1.00 129.59 ? 317 ARG A CD    1 
ATOM   1435  N  NE    . ARG A 1 325 ? 70.733  82.576  80.850  1.00 129.98 ? 317 ARG A NE    1 
ATOM   1436  C  CZ    . ARG A 1 325 ? 70.436  82.548  82.142  1.00 134.85 ? 317 ARG A CZ    1 
ATOM   1437  N  NH1   . ARG A 1 325 ? 70.156  81.413  82.762  1.00 135.66 ? 317 ARG A NH1   1 
ATOM   1438  N  NH2   . ARG A 1 325 ? 70.418  83.686  82.829  1.00 134.65 ? 317 ARG A NH2   1 
ATOM   1439  N  N     . LEU A 1 326 ? 73.155  77.151  77.303  1.00 137.87 ? 318 LEU A N     1 
ATOM   1440  C  CA    . LEU A 1 326 ? 72.994  75.800  76.778  1.00 138.91 ? 318 LEU A CA    1 
ATOM   1441  C  C     . LEU A 1 326 ? 74.258  74.977  76.978  1.00 139.74 ? 318 LEU A C     1 
ATOM   1442  O  O     . LEU A 1 326 ? 74.187  73.797  77.347  1.00 142.56 ? 318 LEU A O     1 
ATOM   1443  C  CB    . LEU A 1 326 ? 72.613  75.852  75.299  1.00 138.74 ? 318 LEU A CB    1 
ATOM   1444  C  CG    . LEU A 1 326 ? 71.217  76.392  74.982  1.00 142.52 ? 318 LEU A CG    1 
ATOM   1445  C  CD1   . LEU A 1 326 ? 70.951  76.354  73.485  1.00 141.75 ? 318 LEU A CD1   1 
ATOM   1446  C  CD2   . LEU A 1 326 ? 70.154  75.611  75.739  1.00 143.25 ? 318 LEU A CD2   1 
ATOM   1447  N  N     . THR A 1 327 ? 75.429  75.580  76.745  1.00 137.46 ? 319 THR A N     1 
ATOM   1448  C  CA    . THR A 1 327 ? 76.677  74.848  76.935  1.00 135.60 ? 319 THR A CA    1 
ATOM   1449  C  C     . THR A 1 327 ? 76.857  74.431  78.390  1.00 138.06 ? 319 THR A C     1 
ATOM   1450  O  O     . THR A 1 327 ? 77.239  73.289  78.676  1.00 138.28 ? 319 THR A O     1 
ATOM   1451  C  CB    . THR A 1 327 ? 77.858  75.697  76.470  1.00 130.77 ? 319 THR A CB    1 
ATOM   1452  O  OG1   . THR A 1 327 ? 77.602  76.188  75.148  1.00 132.89 ? 319 THR A OG1   1 
ATOM   1453  C  CG2   . THR A 1 327 ? 79.128  74.870  76.453  1.00 123.92 ? 319 THR A CG2   1 
ATOM   1454  N  N     . ALA A 1 328 ? 76.574  75.343  79.324  1.00 140.60 ? 320 ALA A N     1 
ATOM   1455  C  CA    . ALA A 1 328 ? 76.706  75.029  80.740  1.00 143.14 ? 320 ALA A CA    1 
ATOM   1456  C  C     . ALA A 1 328 ? 75.721  73.949  81.163  1.00 145.95 ? 320 ALA A C     1 
ATOM   1457  O  O     . ALA A 1 328 ? 76.076  73.051  81.932  1.00 147.90 ? 320 ALA A O     1 
ATOM   1458  C  CB    . ALA A 1 328 ? 76.513  76.292  81.579  1.00 140.93 ? 320 ALA A CB    1 
ATOM   1459  N  N     . GLU A 1 329 ? 74.479  74.018  80.677  1.00 144.41 ? 321 GLU A N     1 
ATOM   1460  C  CA    . GLU A 1 329 ? 73.506  72.983  81.011  1.00 143.41 ? 321 GLU A CA    1 
ATOM   1461  C  C     . GLU A 1 329 ? 73.944  71.625  80.481  1.00 145.65 ? 321 GLU A C     1 
ATOM   1462  O  O     . GLU A 1 329 ? 73.873  70.617  81.197  1.00 147.93 ? 321 GLU A O     1 
ATOM   1463  C  CB    . GLU A 1 329 ? 72.129  73.356  80.464  1.00 141.40 ? 321 GLU A CB    1 
ATOM   1464  C  CG    . GLU A 1 329 ? 71.481  74.536  81.170  1.00 141.89 ? 321 GLU A CG    1 
ATOM   1465  C  CD    . GLU A 1 329 ? 70.136  74.905  80.577  1.00 144.09 ? 321 GLU A CD    1 
ATOM   1466  O  OE1   . GLU A 1 329 ? 69.710  74.243  79.607  1.00 146.22 ? 321 GLU A OE1   1 
ATOM   1467  O  OE2   . GLU A 1 329 ? 69.505  75.858  81.081  1.00 143.90 ? 321 GLU A OE2   1 
ATOM   1468  N  N     . ARG A 1 330 ? 74.419  71.580  79.232  1.00 145.24 ? 322 ARG A N     1 
ATOM   1469  C  CA    . ARG A 1 330 ? 74.858  70.312  78.659  1.00 146.60 ? 322 ARG A CA    1 
ATOM   1470  C  C     . ARG A 1 330 ? 76.043  69.742  79.427  1.00 148.55 ? 322 ARG A C     1 
ATOM   1471  O  O     . ARG A 1 330 ? 76.108  68.531  79.672  1.00 150.45 ? 322 ARG A O     1 
ATOM   1472  C  CB    . ARG A 1 330 ? 75.214  70.491  77.184  1.00 142.97 ? 322 ARG A CB    1 
ATOM   1473  C  CG    . ARG A 1 330 ? 75.470  69.180  76.458  1.00 141.19 ? 322 ARG A CG    1 
ATOM   1474  C  CD    . ARG A 1 330 ? 76.067  69.407  75.081  1.00 140.55 ? 322 ARG A CD    1 
ATOM   1475  N  NE    . ARG A 1 330 ? 77.417  69.951  75.156  1.00 138.97 ? 322 ARG A NE    1 
ATOM   1476  C  CZ    . ARG A 1 330 ? 78.207  70.141  74.109  1.00 137.76 ? 322 ARG A CZ    1 
ATOM   1477  N  NH1   . ARG A 1 330 ? 77.813  69.840  72.882  1.00 141.08 ? 322 ARG A NH1   1 
ATOM   1478  N  NH2   . ARG A 1 330 ? 79.423  70.645  74.296  1.00 133.07 ? 322 ARG A NH2   1 
ATOM   1479  N  N     . GLU A 1 331 ? 76.995  70.596  79.810  1.00 147.06 ? 323 GLU A N     1 
ATOM   1480  C  CA    . GLU A 1 331 ? 78.143  70.114  80.571  1.00 146.44 ? 323 GLU A CA    1 
ATOM   1481  C  C     . GLU A 1 331 ? 77.732  69.637  81.960  1.00 149.85 ? 323 GLU A C     1 
ATOM   1482  O  O     . GLU A 1 331 ? 78.219  68.605  82.435  1.00 149.61 ? 323 GLU A O     1 
ATOM   1483  C  CB    . GLU A 1 331 ? 79.205  71.208  80.669  1.00 142.72 ? 323 GLU A CB    1 
ATOM   1484  C  CG    . GLU A 1 331 ? 79.881  71.536  79.348  1.00 140.29 ? 323 GLU A CG    1 
ATOM   1485  C  CD    . GLU A 1 331 ? 80.798  70.429  78.865  1.00 140.64 ? 323 GLU A CD    1 
ATOM   1486  O  OE1   . GLU A 1 331 ? 81.163  69.554  79.679  1.00 139.58 ? 323 GLU A OE1   1 
ATOM   1487  O  OE2   . GLU A 1 331 ? 81.155  70.434  77.668  1.00 142.41 ? 323 GLU A OE2   1 
ATOM   1488  N  N     . LEU A 1 332 ? 76.832  70.368  82.623  1.00 152.59 ? 324 LEU A N     1 
ATOM   1489  C  CA    . LEU A 1 332 ? 76.408  69.994  83.966  1.00 154.64 ? 324 LEU A CA    1 
ATOM   1490  C  C     . LEU A 1 332 ? 75.500  68.774  83.972  1.00 155.52 ? 324 LEU A C     1 
ATOM   1491  O  O     . LEU A 1 332 ? 75.309  68.169  85.032  1.00 156.61 ? 324 LEU A O     1 
ATOM   1492  C  CB    . LEU A 1 332 ? 75.703  71.170  84.643  1.00 152.16 ? 324 LEU A CB    1 
ATOM   1493  C  CG    . LEU A 1 332 ? 76.595  72.342  85.055  1.00 149.72 ? 324 LEU A CG    1 
ATOM   1494  C  CD1   . LEU A 1 332 ? 75.765  73.455  85.675  1.00 147.72 ? 324 LEU A CD1   1 
ATOM   1495  C  CD2   . LEU A 1 332 ? 77.676  71.876  86.016  1.00 149.45 ? 324 LEU A CD2   1 
ATOM   1496  N  N     . MET A 1 333 ? 74.926  68.407  82.823  1.00 155.08 ? 325 MET A N     1 
ATOM   1497  C  CA    . MET A 1 333 ? 74.164  67.164  82.759  1.00 155.84 ? 325 MET A CA    1 
ATOM   1498  C  C     . MET A 1 333 ? 75.029  65.959  83.107  1.00 157.32 ? 325 MET A C     1 
ATOM   1499  O  O     . MET A 1 333 ? 74.536  64.990  83.696  1.00 158.91 ? 325 MET A O     1 
ATOM   1500  C  CB    . MET A 1 333 ? 73.545  66.991  81.372  1.00 153.79 ? 325 MET A CB    1 
ATOM   1501  C  CG    . MET A 1 333 ? 72.316  67.852  81.128  1.00 153.20 ? 325 MET A CG    1 
ATOM   1502  S  SD    . MET A 1 333 ? 71.601  67.596  79.493  1.00 156.45 ? 325 MET A SD    1 
ATOM   1503  C  CE    . MET A 1 333 ? 70.194  68.701  79.561  1.00 150.56 ? 325 MET A CE    1 
ATOM   1504  N  N     . GLY A 1 334 ? 76.313  65.998  82.756  1.00 156.11 ? 326 GLY A N     1 
ATOM   1505  C  CA    . GLY A 1 334 ? 77.216  64.909  83.072  1.00 156.14 ? 326 GLY A CA    1 
ATOM   1506  C  C     . GLY A 1 334 ? 78.205  65.228  84.175  1.00 156.88 ? 326 GLY A C     1 
ATOM   1507  O  O     . GLY A 1 334 ? 78.509  64.370  85.009  1.00 157.28 ? 326 GLY A O     1 
ATOM   1508  N  N     . MET A 1 335 ? 78.715  66.462  84.192  1.00 156.85 ? 327 MET A N     1 
ATOM   1509  C  CA    . MET A 1 335 ? 79.710  66.835  85.194  1.00 156.50 ? 327 MET A CA    1 
ATOM   1510  C  C     . MET A 1 335 ? 79.076  67.027  86.567  1.00 155.96 ? 327 MET A C     1 
ATOM   1511  O  O     . MET A 1 335 ? 79.651  66.617  87.582  1.00 153.60 ? 327 MET A O     1 
ATOM   1512  C  CB    . MET A 1 335 ? 80.442  68.105  84.762  1.00 153.45 ? 327 MET A CB    1 
ATOM   1513  C  CG    . MET A 1 335 ? 81.259  67.951  83.489  1.00 150.96 ? 327 MET A CG    1 
ATOM   1514  S  SD    . MET A 1 335 ? 82.589  66.746  83.660  1.00 150.69 ? 327 MET A SD    1 
ATOM   1515  C  CE    . MET A 1 335 ? 83.544  67.482  84.984  1.00 142.67 ? 327 MET A CE    1 
ATOM   1516  N  N     . LEU A 1 336 ? 77.904  67.661  86.617  1.00 158.39 ? 328 LEU A N     1 
ATOM   1517  C  CA    . LEU A 1 336 ? 77.122  67.939  87.819  1.00 161.13 ? 328 LEU A CA    1 
ATOM   1518  C  C     . LEU A 1 336 ? 77.805  68.911  88.775  1.00 161.41 ? 328 LEU A C     1 
ATOM   1519  O  O     . LEU A 1 336 ? 77.241  69.208  89.835  1.00 159.03 ? 328 LEU A O     1 
ATOM   1520  C  CB    . LEU A 1 336 ? 76.765  66.662  88.596  1.00 161.85 ? 328 LEU A CB    1 
ATOM   1521  C  CG    . LEU A 1 336 ? 75.893  65.629  87.879  1.00 159.58 ? 328 LEU A CG    1 
ATOM   1522  C  CD1   . LEU A 1 336 ? 75.734  64.381  88.734  1.00 155.89 ? 328 LEU A CD1   1 
ATOM   1523  C  CD2   . LEU A 1 336 ? 74.535  66.218  87.533  1.00 157.65 ? 328 LEU A CD2   1 
ATOM   1524  N  N     . SER A 1 337 ? 78.989  69.423  88.443  1.00 161.26 ? 329 SER A N     1 
ATOM   1525  C  CA    . SER A 1 337 ? 79.686  70.351  89.324  1.00 155.53 ? 329 SER A CA    1 
ATOM   1526  C  C     . SER A 1 337 ? 80.712  71.131  88.515  1.00 151.77 ? 329 SER A C     1 
ATOM   1527  O  O     . SER A 1 337 ? 81.088  70.736  87.408  1.00 151.46 ? 329 SER A O     1 
ATOM   1528  C  CB    . SER A 1 337 ? 80.363  69.620  90.489  1.00 152.63 ? 329 SER A CB    1 
ATOM   1529  O  OG    . SER A 1 337 ? 81.333  68.700  90.020  1.00 152.85 ? 329 SER A OG    1 
ATOM   1530  N  N     . THR A 1 338 ? 81.160  72.245  89.088  1.00 148.34 ? 330 THR A N     1 
ATOM   1531  C  CA    . THR A 1 338 ? 82.168  73.103  88.480  1.00 143.90 ? 330 THR A CA    1 
ATOM   1532  C  C     . THR A 1 338 ? 83.402  73.127  89.370  1.00 141.10 ? 330 THR A C     1 
ATOM   1533  O  O     . THR A 1 338 ? 83.294  73.339  90.582  1.00 139.17 ? 330 THR A O     1 
ATOM   1534  C  CB    . THR A 1 338 ? 81.641  74.526  88.274  1.00 138.59 ? 330 THR A CB    1 
ATOM   1535  O  OG1   . THR A 1 338 ? 81.404  75.138  89.547  1.00 135.04 ? 330 THR A OG1   1 
ATOM   1536  C  CG2   . THR A 1 338 ? 80.345  74.505  87.480  1.00 138.51 ? 330 THR A CG2   1 
ATOM   1537  N  N     . SER A 1 339 ? 84.571  72.912  88.767  1.00 138.32 ? 331 SER A N     1 
ATOM   1538  C  CA    . SER A 1 339 ? 85.822  72.894  89.515  1.00 132.55 ? 331 SER A CA    1 
ATOM   1539  C  C     . SER A 1 339 ? 86.475  74.269  89.587  1.00 126.99 ? 331 SER A C     1 
ATOM   1540  O  O     . SER A 1 339 ? 86.953  74.671  90.653  1.00 122.74 ? 331 SER A O     1 
ATOM   1541  C  CB    . SER A 1 339 ? 86.794  71.889  88.890  1.00 130.10 ? 331 SER A CB    1 
ATOM   1542  O  OG    . SER A 1 339 ? 86.257  70.578  88.915  1.00 132.07 ? 331 SER A OG    1 
ATOM   1543  N  N     . LEU A 1 340 ? 86.506  75.000  88.472  1.00 126.91 ? 332 LEU A N     1 
ATOM   1544  C  CA    . LEU A 1 340 ? 87.081  76.339  88.427  1.00 122.39 ? 332 LEU A CA    1 
ATOM   1545  C  C     . LEU A 1 340 ? 86.029  77.404  88.138  1.00 122.72 ? 332 LEU A C     1 
ATOM   1546  O  O     . LEU A 1 340 ? 86.362  78.472  87.615  1.00 122.30 ? 332 LEU A O     1 
ATOM   1547  C  CB    . LEU A 1 340 ? 88.204  76.403  87.391  1.00 118.50 ? 332 LEU A CB    1 
ATOM   1548  C  CG    . LEU A 1 340 ? 89.386  75.464  87.638  1.00 117.78 ? 332 LEU A CG    1 
ATOM   1549  C  CD1   . LEU A 1 340 ? 90.481  75.691  86.609  1.00 114.96 ? 332 LEU A CD1   1 
ATOM   1550  C  CD2   . LEU A 1 340 ? 89.924  75.642  89.047  1.00 119.20 ? 332 LEU A CD2   1 
ATOM   1551  N  N     . ALA A 1 341 ? 84.772  77.123  88.459  1.00 122.61 ? 333 ALA A N     1 
ATOM   1552  C  CA    . ALA A 1 341 ? 83.648  78.067  88.327  1.00 118.77 ? 333 ALA A CA    1 
ATOM   1553  C  C     . ALA A 1 341 ? 83.499  78.432  86.846  1.00 117.88 ? 333 ALA A C     1 
ATOM   1554  O  O     . ALA A 1 341 ? 83.751  77.584  85.974  1.00 120.76 ? 333 ALA A O     1 
ATOM   1555  C  CB    . ALA A 1 341 ? 83.852  79.244  89.260  1.00 121.05 ? 333 ALA A CB    1 
ATOM   1556  N  N     . ASP A 1 342 ? 83.125  79.678  86.537  1.00 118.49 ? 334 ASP A N     1 
ATOM   1557  C  CA    . ASP A 1 342 ? 82.753  80.047  85.174  1.00 118.96 ? 334 ASP A CA    1 
ATOM   1558  C  C     . ASP A 1 342 ? 83.882  79.800  84.186  1.00 117.76 ? 334 ASP A C     1 
ATOM   1559  O  O     . ASP A 1 342 ? 83.624  79.582  82.995  1.00 120.41 ? 334 ASP A O     1 
ATOM   1560  C  CB    . ASP A 1 342 ? 82.329  81.514  85.123  1.00 118.83 ? 334 ASP A CB    1 
ATOM   1561  C  CG    . ASP A 1 342 ? 83.501  82.465  85.274  1.00 117.14 ? 334 ASP A CG    1 
ATOM   1562  O  OD1   . ASP A 1 342 ? 84.431  82.151  86.046  1.00 116.89 ? 334 ASP A OD1   1 
ATOM   1563  O  OD2   . ASP A 1 342 ? 83.494  83.525  84.617  1.00 114.01 ? 334 ASP A OD2   1 
ATOM   1564  N  N     . GLN A 1 343 ? 85.133  79.832  84.655  1.00 113.72 ? 335 GLN A N     1 
ATOM   1565  C  CA    . GLN A 1 343 ? 86.263  79.539  83.783  1.00 110.83 ? 335 GLN A CA    1 
ATOM   1566  C  C     . GLN A 1 343 ? 86.052  78.218  83.058  1.00 115.13 ? 335 GLN A C     1 
ATOM   1567  O  O     . GLN A 1 343 ? 86.161  78.147  81.827  1.00 117.47 ? 335 GLN A O     1 
ATOM   1568  C  CB    . GLN A 1 343 ? 87.558  79.508  84.594  1.00 105.06 ? 335 GLN A CB    1 
ATOM   1569  C  CG    . GLN A 1 343 ? 88.799  79.225  83.767  1.00 99.97  ? 335 GLN A CG    1 
ATOM   1570  C  CD    . GLN A 1 343 ? 90.041  79.067  84.618  1.00 95.70  ? 335 GLN A CD    1 
ATOM   1571  O  OE1   . GLN A 1 343 ? 89.955  78.853  85.826  1.00 98.55  ? 335 GLN A OE1   1 
ATOM   1572  N  NE2   . GLN A 1 343 ? 91.205  79.173  83.990  1.00 89.87  ? 335 GLN A NE2   1 
ATOM   1573  N  N     . ASP A 1 344 ? 85.699  77.168  83.807  1.00 115.35 ? 336 ASP A N     1 
ATOM   1574  C  CA    . ASP A 1 344 ? 85.401  75.882  83.187  1.00 118.38 ? 336 ASP A CA    1 
ATOM   1575  C  C     . ASP A 1 344 ? 84.342  76.039  82.106  1.00 121.30 ? 336 ASP A C     1 
ATOM   1576  O  O     . ASP A 1 344 ? 84.521  75.582  80.969  1.00 121.55 ? 336 ASP A O     1 
ATOM   1577  C  CB    . ASP A 1 344 ? 84.943  74.882  84.247  1.00 123.51 ? 336 ASP A CB    1 
ATOM   1578  C  CG    . ASP A 1 344 ? 86.047  74.507  85.210  1.00 128.53 ? 336 ASP A CG    1 
ATOM   1579  O  OD1   . ASP A 1 344 ? 87.230  74.581  84.815  1.00 129.28 ? 336 ASP A OD1   1 
ATOM   1580  O  OD2   . ASP A 1 344 ? 85.733  74.135  86.359  1.00 130.54 ? 336 ASP A OD2   1 
ATOM   1581  N  N     . ILE A 1 345 ? 83.249  76.734  82.435  1.00 121.68 ? 337 ILE A N     1 
ATOM   1582  C  CA    . ILE A 1 345 ? 82.192  76.970  81.458  1.00 118.26 ? 337 ILE A CA    1 
ATOM   1583  C  C     . ILE A 1 345 ? 82.761  77.642  80.219  1.00 115.94 ? 337 ILE A C     1 
ATOM   1584  O  O     . ILE A 1 345 ? 82.469  77.235  79.087  1.00 118.93 ? 337 ILE A O     1 
ATOM   1585  C  CB    . ILE A 1 345 ? 81.057  77.799  82.085  1.00 118.36 ? 337 ILE A CB    1 
ATOM   1586  C  CG1   . ILE A 1 345 ? 80.377  77.007  83.203  1.00 123.49 ? 337 ILE A CG1   1 
ATOM   1587  C  CG2   . ILE A 1 345 ? 80.047  78.209  81.027  1.00 118.48 ? 337 ILE A CG2   1 
ATOM   1588  C  CD1   . ILE A 1 345 ? 79.235  77.743  83.867  1.00 126.48 ? 337 ILE A CD1   1 
ATOM   1589  N  N     . PHE A 1 346 ? 83.611  78.657  80.412  1.00 113.07 ? 338 PHE A N     1 
ATOM   1590  C  CA    . PHE A 1 346 ? 84.252  79.307  79.276  1.00 109.75 ? 338 PHE A CA    1 
ATOM   1591  C  C     . PHE A 1 346 ? 84.918  78.278  78.376  1.00 113.25 ? 338 PHE A C     1 
ATOM   1592  O  O     . PHE A 1 346 ? 84.661  78.232  77.167  1.00 117.35 ? 338 PHE A O     1 
ATOM   1593  C  CB    . PHE A 1 346 ? 85.276  80.335  79.761  1.00 110.80 ? 338 PHE A CB    1 
ATOM   1594  C  CG    . PHE A 1 346 ? 84.729  81.727  79.889  1.00 111.09 ? 338 PHE A CG    1 
ATOM   1595  C  CD1   . PHE A 1 346 ? 84.639  82.551  78.781  1.00 106.18 ? 338 PHE A CD1   1 
ATOM   1596  C  CD2   . PHE A 1 346 ? 84.318  82.216  81.117  1.00 111.10 ? 338 PHE A CD2   1 
ATOM   1597  C  CE1   . PHE A 1 346 ? 84.141  83.834  78.893  1.00 107.33 ? 338 PHE A CE1   1 
ATOM   1598  C  CE2   . PHE A 1 346 ? 83.821  83.500  81.235  1.00 107.88 ? 338 PHE A CE2   1 
ATOM   1599  C  CZ    . PHE A 1 346 ? 83.731  84.309  80.122  1.00 107.04 ? 338 PHE A CZ    1 
ATOM   1600  N  N     . ASN A 1 347 ? 85.729  77.397  78.971  1.00 115.65 ? 339 ASN A N     1 
ATOM   1601  C  CA    . ASN A 1 347 ? 86.431  76.392  78.182  1.00 116.67 ? 339 ASN A CA    1 
ATOM   1602  C  C     . ASN A 1 347 ? 85.449  75.537  77.397  1.00 117.05 ? 339 ASN A C     1 
ATOM   1603  O  O     . ASN A 1 347 ? 85.692  75.214  76.228  1.00 115.25 ? 339 ASN A O     1 
ATOM   1604  C  CB    . ASN A 1 347 ? 87.301  75.525  79.090  1.00 118.42 ? 339 ASN A CB    1 
ATOM   1605  C  CG    . ASN A 1 347 ? 88.357  76.329  79.823  1.00 114.39 ? 339 ASN A CG    1 
ATOM   1606  O  OD1   . ASN A 1 347 ? 89.453  76.551  79.309  1.00 109.63 ? 339 ASN A OD1   1 
ATOM   1607  N  ND2   . ASN A 1 347 ? 88.030  76.770  81.031  1.00 114.03 ? 339 ASN A ND2   1 
ATOM   1608  N  N     . ALA A 1 348 ? 84.313  75.197  78.012  1.00 119.50 ? 340 ALA A N     1 
ATOM   1609  C  CA    . ALA A 1 348 ? 83.315  74.396  77.315  1.00 120.18 ? 340 ALA A CA    1 
ATOM   1610  C  C     . ALA A 1 348 ? 82.844  75.098  76.049  1.00 115.77 ? 340 ALA A C     1 
ATOM   1611  O  O     . ALA A 1 348 ? 82.754  74.477  74.983  1.00 117.74 ? 340 ALA A O     1 
ATOM   1612  C  CB    . ALA A 1 348 ? 82.139  74.100  78.243  1.00 123.03 ? 340 ALA A CB    1 
ATOM   1613  N  N     . VAL A 1 349 ? 82.578  76.404  76.138  1.00 113.82 ? 341 VAL A N     1 
ATOM   1614  C  CA    . VAL A 1 349 ? 82.211  77.157  74.944  1.00 110.28 ? 341 VAL A CA    1 
ATOM   1615  C  C     . VAL A 1 349 ? 83.341  77.103  73.928  1.00 111.29 ? 341 VAL A C     1 
ATOM   1616  O  O     . VAL A 1 349 ? 83.110  76.910  72.727  1.00 117.50 ? 341 VAL A O     1 
ATOM   1617  C  CB    . VAL A 1 349 ? 81.846  78.607  75.312  1.00 112.76 ? 341 VAL A CB    1 
ATOM   1618  C  CG1   . VAL A 1 349 ? 81.513  79.402  74.062  1.00 112.90 ? 341 VAL A CG1   1 
ATOM   1619  C  CG2   . VAL A 1 349 ? 80.681  78.625  76.288  1.00 116.78 ? 341 VAL A CG2   1 
ATOM   1620  N  N     . ILE A 1 350 ? 84.584  77.231  74.401  1.00 108.23 ? 342 ILE A N     1 
ATOM   1621  C  CA    . ILE A 1 350 ? 85.736  77.153  73.511  1.00 110.78 ? 342 ILE A CA    1 
ATOM   1622  C  C     . ILE A 1 350 ? 85.771  75.808  72.800  1.00 118.13 ? 342 ILE A C     1 
ATOM   1623  O  O     . ILE A 1 350 ? 86.271  75.703  71.673  1.00 119.03 ? 342 ILE A O     1 
ATOM   1624  C  CB    . ILE A 1 350 ? 87.030  77.415  74.305  1.00 111.96 ? 342 ILE A CB    1 
ATOM   1625  C  CG1   . ILE A 1 350 ? 86.917  78.731  75.073  1.00 107.40 ? 342 ILE A CG1   1 
ATOM   1626  C  CG2   . ILE A 1 350 ? 88.236  77.451  73.379  1.00 112.32 ? 342 ILE A CG2   1 
ATOM   1627  C  CD1   . ILE A 1 350 ? 88.049  78.975  76.039  1.00 106.26 ? 342 ILE A CD1   1 
ATOM   1628  N  N     . LYS A 1 351 ? 85.232  74.763  73.432  1.00 120.09 ? 343 LYS A N     1 
ATOM   1629  C  CA    . LYS A 1 351 ? 85.165  73.469  72.764  1.00 119.90 ? 343 LYS A CA    1 
ATOM   1630  C  C     . LYS A 1 351 ? 84.152  73.486  71.626  1.00 116.63 ? 343 LYS A C     1 
ATOM   1631  O  O     . LYS A 1 351 ? 84.412  72.936  70.549  1.00 114.51 ? 343 LYS A O     1 
ATOM   1632  C  CB    . LYS A 1 351 ? 84.823  72.371  73.770  1.00 119.23 ? 343 LYS A CB    1 
ATOM   1633  C  CG    . LYS A 1 351 ? 84.810  70.975  73.171  1.00 121.59 ? 343 LYS A CG    1 
ATOM   1634  C  CD    . LYS A 1 351 ? 84.474  69.927  74.216  1.00 125.37 ? 343 LYS A CD    1 
ATOM   1635  C  CE    . LYS A 1 351 ? 84.557  68.524  73.637  1.00 127.68 ? 343 LYS A CE    1 
ATOM   1636  N  NZ    . LYS A 1 351 ? 84.266  67.484  74.662  1.00 128.63 ? 343 LYS A NZ    1 
ATOM   1637  N  N     . GLN A 1 352 ? 82.993  74.113  71.841  1.00 114.81 ? 344 GLN A N     1 
ATOM   1638  C  CA    . GLN A 1 352 ? 81.950  74.080  70.821  1.00 111.82 ? 344 GLN A CA    1 
ATOM   1639  C  C     . GLN A 1 352 ? 82.279  74.999  69.653  1.00 110.47 ? 344 GLN A C     1 
ATOM   1640  O  O     . GLN A 1 352 ? 82.099  74.620  68.490  1.00 115.38 ? 344 GLN A O     1 
ATOM   1641  C  CB    . GLN A 1 352 ? 80.601  74.456  71.432  1.00 114.54 ? 344 GLN A CB    1 
ATOM   1642  C  CG    . GLN A 1 352 ? 80.048  73.429  72.401  1.00 121.91 ? 344 GLN A CG    1 
ATOM   1643  C  CD    . GLN A 1 352 ? 78.643  73.765  72.856  1.00 129.34 ? 344 GLN A CD    1 
ATOM   1644  O  OE1   . GLN A 1 352 ? 78.107  73.141  73.771  1.00 132.74 ? 344 GLN A OE1   1 
ATOM   1645  N  NE2   . GLN A 1 352 ? 78.036  74.758  72.216  1.00 127.19 ? 344 GLN A NE2   1 
ATOM   1646  N  N     . ASN A 1 353 ? 82.761  76.206  69.937  1.00 108.27 ? 345 ASN A N     1 
ATOM   1647  C  CA    . ASN A 1 353 ? 83.030  77.215  68.913  1.00 107.84 ? 345 ASN A CA    1 
ATOM   1648  C  C     . ASN A 1 353 ? 84.438  77.760  69.112  1.00 106.48 ? 345 ASN A C     1 
ATOM   1649  O  O     . ASN A 1 353 ? 84.622  78.862  69.646  1.00 107.13 ? 345 ASN A O     1 
ATOM   1650  C  CB    . ASN A 1 353 ? 81.990  78.335  68.960  1.00 108.69 ? 345 ASN A CB    1 
ATOM   1651  C  CG    . ASN A 1 353 ? 80.573  77.819  68.795  1.00 109.96 ? 345 ASN A CG    1 
ATOM   1652  O  OD1   . ASN A 1 353 ? 80.034  77.792  67.689  1.00 101.97 ? 345 ASN A OD1   1 
ATOM   1653  N  ND2   . ASN A 1 353 ? 79.962  77.403  69.898  1.00 112.50 ? 345 ASN A ND2   1 
ATOM   1654  N  N     . PRO A 1 354 ? 85.460  77.009  68.695  1.00 104.00 ? 346 PRO A N     1 
ATOM   1655  C  CA    . PRO A 1 354 ? 86.840  77.499  68.847  1.00 102.20 ? 346 PRO A CA    1 
ATOM   1656  C  C     . PRO A 1 354 ? 87.132  78.762  68.058  1.00 97.58  ? 346 PRO A C     1 
ATOM   1657  O  O     . PRO A 1 354 ? 88.094  79.468  68.384  1.00 95.37  ? 346 PRO A O     1 
ATOM   1658  C  CB    . PRO A 1 354 ? 87.688  76.321  68.347  1.00 103.66 ? 346 PRO A CB    1 
ATOM   1659  C  CG    . PRO A 1 354 ? 86.787  75.129  68.436  1.00 105.00 ? 346 PRO A CG    1 
ATOM   1660  C  CD    . PRO A 1 354 ? 85.416  75.647  68.142  1.00 103.44 ? 346 PRO A CD    1 
ATOM   1661  N  N     . PHE A 1 355 ? 86.342  79.069  67.028  1.00 96.01  ? 347 PHE A N     1 
ATOM   1662  C  CA    . PHE A 1 355 ? 86.588  80.248  66.207  1.00 96.72  ? 347 PHE A CA    1 
ATOM   1663  C  C     . PHE A 1 355 ? 86.270  81.554  66.925  1.00 95.52  ? 347 PHE A C     1 
ATOM   1664  O  O     . PHE A 1 355 ? 86.621  82.620  66.410  1.00 94.15  ? 347 PHE A O     1 
ATOM   1665  C  CB    . PHE A 1 355 ? 85.781  80.163  64.910  1.00 98.16  ? 347 PHE A CB    1 
ATOM   1666  C  CG    . PHE A 1 355 ? 84.307  79.959  65.123  1.00 104.33 ? 347 PHE A CG    1 
ATOM   1667  C  CD1   . PHE A 1 355 ? 83.777  78.683  65.224  1.00 107.95 ? 347 PHE A CD1   1 
ATOM   1668  C  CD2   . PHE A 1 355 ? 83.449  81.043  65.214  1.00 102.82 ? 347 PHE A CD2   1 
ATOM   1669  C  CE1   . PHE A 1 355 ? 82.423  78.492  65.418  1.00 110.68 ? 347 PHE A CE1   1 
ATOM   1670  C  CE2   . PHE A 1 355 ? 82.093  80.857  65.408  1.00 103.37 ? 347 PHE A CE2   1 
ATOM   1671  C  CZ    . PHE A 1 355 ? 81.580  79.580  65.510  1.00 107.25 ? 347 PHE A CZ    1 
ATOM   1672  N  N     . LEU A 1 356 ? 85.611  81.502  68.082  1.00 94.30  ? 348 LEU A N     1 
ATOM   1673  C  CA    . LEU A 1 356 ? 85.281  82.710  68.827  1.00 89.66  ? 348 LEU A CA    1 
ATOM   1674  C  C     . LEU A 1 356 ? 86.433  83.225  69.677  1.00 83.20  ? 348 LEU A C     1 
ATOM   1675  O  O     . LEU A 1 356 ? 86.364  84.361  70.158  1.00 81.90  ? 348 LEU A O     1 
ATOM   1676  C  CB    . LEU A 1 356 ? 84.072  82.460  69.733  1.00 90.23  ? 348 LEU A CB    1 
ATOM   1677  C  CG    . LEU A 1 356 ? 82.748  82.087  69.069  1.00 98.68  ? 348 LEU A CG    1 
ATOM   1678  C  CD1   . LEU A 1 356 ? 81.686  81.821  70.125  1.00 97.54  ? 348 LEU A CD1   1 
ATOM   1679  C  CD2   . LEU A 1 356 ? 82.301  83.185  68.120  1.00 98.30  ? 348 LEU A CD2   1 
ATOM   1680  N  N     . VAL A 1 357 ? 87.483  82.432  69.870  1.00 82.10  ? 349 VAL A N     1 
ATOM   1681  C  CA    . VAL A 1 357 ? 88.537  82.731  70.832  1.00 72.01  ? 349 VAL A CA    1 
ATOM   1682  C  C     . VAL A 1 357 ? 89.769  83.220  70.087  1.00 73.29  ? 349 VAL A C     1 
ATOM   1683  O  O     . VAL A 1 357 ? 90.206  82.594  69.114  1.00 82.49  ? 349 VAL A O     1 
ATOM   1684  C  CB    . VAL A 1 357 ? 88.870  81.500  71.691  1.00 71.14  ? 349 VAL A CB    1 
ATOM   1685  C  CG1   . VAL A 1 357 ? 89.860  81.866  72.781  1.00 70.74  ? 349 VAL A CG1   1 
ATOM   1686  C  CG2   . VAL A 1 357 ? 87.602  80.914  72.285  1.00 72.66  ? 349 VAL A CG2   1 
ATOM   1687  N  N     . TYR A 1 358 ? 90.325  84.337  70.542  1.00 65.23  ? 350 TYR A N     1 
ATOM   1688  C  CA    . TYR A 1 358 ? 91.578  84.874  70.034  1.00 66.41  ? 350 TYR A CA    1 
ATOM   1689  C  C     . TYR A 1 358 ? 92.663  84.581  71.060  1.00 68.46  ? 350 TYR A C     1 
ATOM   1690  O  O     . TYR A 1 358 ? 92.568  85.020  72.212  1.00 70.34  ? 350 TYR A O     1 
ATOM   1691  C  CB    . TYR A 1 358 ? 91.464  86.375  69.774  1.00 65.81  ? 350 TYR A CB    1 
ATOM   1692  C  CG    . TYR A 1 358 ? 92.732  87.026  69.270  1.00 65.10  ? 350 TYR A CG    1 
ATOM   1693  C  CD1   . TYR A 1 358 ? 93.671  87.537  70.153  1.00 65.74  ? 350 TYR A CD1   1 
ATOM   1694  C  CD2   . TYR A 1 358 ? 92.982  87.141  67.912  1.00 66.99  ? 350 TYR A CD2   1 
ATOM   1695  C  CE1   . TYR A 1 358 ? 94.827  88.136  69.697  1.00 65.98  ? 350 TYR A CE1   1 
ATOM   1696  C  CE2   . TYR A 1 358 ? 94.135  87.739  67.447  1.00 67.80  ? 350 TYR A CE2   1 
ATOM   1697  C  CZ    . TYR A 1 358 ? 95.053  88.235  68.344  1.00 67.59  ? 350 TYR A CZ    1 
ATOM   1698  O  OH    . TYR A 1 358 ? 96.204  88.832  67.886  1.00 69.77  ? 350 TYR A OH    1 
ATOM   1699  N  N     . GLN A 1 359 ? 93.692  83.851  70.640  1.00 73.56  ? 351 GLN A N     1 
ATOM   1700  C  CA    . GLN A 1 359 ? 94.749  83.411  71.547  1.00 73.79  ? 351 GLN A CA    1 
ATOM   1701  C  C     . GLN A 1 359 ? 95.770  84.532  71.693  1.00 71.97  ? 351 GLN A C     1 
ATOM   1702  O  O     . GLN A 1 359 ? 96.593  84.763  70.805  1.00 71.42  ? 351 GLN A O     1 
ATOM   1703  C  CB    . GLN A 1 359 ? 95.392  82.128  71.035  1.00 76.86  ? 351 GLN A CB    1 
ATOM   1704  C  CG    . GLN A 1 359 ? 96.258  81.417  72.060  1.00 82.16  ? 351 GLN A CG    1 
ATOM   1705  C  CD    . GLN A 1 359 ? 96.614  80.005  71.639  1.00 92.96  ? 351 GLN A CD    1 
ATOM   1706  O  OE1   . GLN A 1 359 ? 96.275  79.568  70.539  1.00 96.38  ? 351 GLN A OE1   1 
ATOM   1707  N  NE2   . GLN A 1 359 ? 97.299  79.281  72.516  1.00 97.44  ? 351 GLN A NE2   1 
ATOM   1708  N  N     . LEU A 1 360 ? 95.710  85.233  72.821  1.00 71.32  ? 352 LEU A N     1 
ATOM   1709  C  CA    . LEU A 1 360 ? 96.648  86.297  73.117  1.00 70.84  ? 352 LEU A CA    1 
ATOM   1710  C  C     . LEU A 1 360 ? 98.026  85.719  73.428  1.00 74.72  ? 352 LEU A C     1 
ATOM   1711  O  O     . LEU A 1 360 ? 98.156  84.539  73.760  1.00 76.10  ? 352 LEU A O     1 
ATOM   1712  C  CB    . LEU A 1 360 ? 96.153  87.121  74.303  1.00 67.48  ? 352 LEU A CB    1 
ATOM   1713  C  CG    . LEU A 1 360 ? 94.819  87.852  74.164  1.00 64.38  ? 352 LEU A CG    1 
ATOM   1714  C  CD1   . LEU A 1 360 ? 94.360  88.373  75.514  1.00 63.43  ? 352 LEU A CD1   1 
ATOM   1715  C  CD2   . LEU A 1 360 ? 94.942  88.991  73.174  1.00 65.28  ? 352 LEU A CD2   1 
ATOM   1716  N  N     . PRO A 1 361 ? 99.074  86.534  73.317  1.00 75.32  ? 353 PRO A N     1 
ATOM   1717  C  CA    . PRO A 1 361 ? 100.399 86.088  73.758  1.00 75.80  ? 353 PRO A CA    1 
ATOM   1718  C  C     . PRO A 1 361 ? 100.395 85.724  75.235  1.00 74.55  ? 353 PRO A C     1 
ATOM   1719  O  O     . PRO A 1 361 ? 99.633  86.276  76.032  1.00 76.04  ? 353 PRO A O     1 
ATOM   1720  C  CB    . PRO A 1 361 ? 101.290 87.301  73.482  1.00 74.87  ? 353 PRO A CB    1 
ATOM   1721  C  CG    . PRO A 1 361 ? 100.605 88.017  72.374  1.00 75.40  ? 353 PRO A CG    1 
ATOM   1722  C  CD    . PRO A 1 361 ? 99.135  87.822  72.605  1.00 73.45  ? 353 PRO A CD    1 
ATOM   1723  N  N     . CYS A 1 362 ? 101.260 84.772  75.592  1.00 76.10  ? 354 CYS A N     1 
ATOM   1724  C  CA    . CYS A 1 362 ? 101.251 84.223  76.945  1.00 74.51  ? 354 CYS A CA    1 
ATOM   1725  C  C     . CYS A 1 362 ? 101.571 85.287  77.990  1.00 71.59  ? 354 CYS A C     1 
ATOM   1726  O  O     . CYS A 1 362 ? 100.972 85.301  79.073  1.00 68.77  ? 354 CYS A O     1 
ATOM   1727  C  CB    . CYS A 1 362 ? 102.239 83.062  77.044  1.00 79.38  ? 354 CYS A CB    1 
ATOM   1728  S  SG    . CYS A 1 362 ? 103.949 83.504  76.664  1.00 98.58  ? 354 CYS A SG    1 
ATOM   1729  N  N     . PHE A 1 363 ? 102.502 86.193  77.685  1.00 72.15  ? 355 PHE A N     1 
ATOM   1730  C  CA    . PHE A 1 363 ? 102.923 87.184  78.670  1.00 75.30  ? 355 PHE A CA    1 
ATOM   1731  C  C     . PHE A 1 363 ? 101.835 88.196  79.011  1.00 74.73  ? 355 PHE A C     1 
ATOM   1732  O  O     . PHE A 1 363 ? 102.096 89.110  79.803  1.00 71.32  ? 355 PHE A O     1 
ATOM   1733  C  CB    . PHE A 1 363 ? 104.181 87.911  78.190  1.00 77.84  ? 355 PHE A CB    1 
ATOM   1734  C  CG    . PHE A 1 363 ? 104.088 88.437  76.787  1.00 76.29  ? 355 PHE A CG    1 
ATOM   1735  C  CD1   . PHE A 1 363 ? 103.521 89.672  76.533  1.00 74.40  ? 355 PHE A CD1   1 
ATOM   1736  C  CD2   . PHE A 1 363 ? 104.589 87.704  75.724  1.00 78.57  ? 355 PHE A CD2   1 
ATOM   1737  C  CE1   . PHE A 1 363 ? 103.441 90.161  75.245  1.00 77.10  ? 355 PHE A CE1   1 
ATOM   1738  C  CE2   . PHE A 1 363 ? 104.514 88.190  74.435  1.00 79.98  ? 355 PHE A CE2   1 
ATOM   1739  C  CZ    . PHE A 1 363 ? 103.939 89.421  74.195  1.00 78.99  ? 355 PHE A CZ    1 
ATOM   1740  N  N     . TRP A 1 364 ? 100.637 88.068  78.440  1.00 76.38  ? 356 TRP A N     1 
ATOM   1741  C  CA    . TRP A 1 364 ? 99.499  88.871  78.867  1.00 69.54  ? 356 TRP A CA    1 
ATOM   1742  C  C     . TRP A 1 364 ? 98.782  88.283  80.072  1.00 65.69  ? 356 TRP A C     1 
ATOM   1743  O  O     . TRP A 1 364 ? 97.887  88.938  80.616  1.00 67.98  ? 356 TRP A O     1 
ATOM   1744  C  CB    . TRP A 1 364 ? 98.496  89.040  77.724  1.00 67.30  ? 356 TRP A CB    1 
ATOM   1745  C  CG    . TRP A 1 364 ? 98.914  90.042  76.705  1.00 67.41  ? 356 TRP A CG    1 
ATOM   1746  C  CD1   . TRP A 1 364 ? 99.170  89.811  75.389  1.00 67.45  ? 356 TRP A CD1   1 
ATOM   1747  C  CD2   . TRP A 1 364 ? 99.136  91.440  76.919  1.00 65.46  ? 356 TRP A CD2   1 
ATOM   1748  N  NE1   . TRP A 1 364 ? 99.533  90.978  74.765  1.00 69.39  ? 356 TRP A NE1   1 
ATOM   1749  C  CE2   . TRP A 1 364 ? 99.521  91.993  75.684  1.00 68.53  ? 356 TRP A CE2   1 
ATOM   1750  C  CE3   . TRP A 1 364 ? 99.044  92.278  78.033  1.00 66.51  ? 356 TRP A CE3   1 
ATOM   1751  C  CZ2   . TRP A 1 364 ? 99.814  93.344  75.532  1.00 69.63  ? 356 TRP A CZ2   1 
ATOM   1752  C  CZ3   . TRP A 1 364 ? 99.337  93.618  77.880  1.00 66.40  ? 356 TRP A CZ3   1 
ATOM   1753  C  CH2   . TRP A 1 364 ? 99.716  94.138  76.639  1.00 67.57  ? 356 TRP A CH2   1 
ATOM   1754  N  N     . ASN A 1 365 ? 99.123  87.063  80.482  1.00 66.39  ? 357 ASN A N     1 
ATOM   1755  C  CA    . ASN A 1 365 ? 98.522  86.466  81.672  1.00 63.48  ? 357 ASN A CA    1 
ATOM   1756  C  C     . ASN A 1 365 ? 99.508  85.433  82.210  1.00 69.75  ? 357 ASN A C     1 
ATOM   1757  O  O     . ASN A 1 365 ? 99.493  84.277  81.780  1.00 75.39  ? 357 ASN A O     1 
ATOM   1758  C  CB    . ASN A 1 365 ? 97.171  85.846  81.344  1.00 61.64  ? 357 ASN A CB    1 
ATOM   1759  C  CG    . ASN A 1 365 ? 96.463  85.315  82.564  1.00 59.31  ? 357 ASN A CG    1 
ATOM   1760  O  OD1   . ASN A 1 365 ? 96.808  85.657  83.692  1.00 65.81  ? 357 ASN A OD1   1 
ATOM   1761  N  ND2   . ASN A 1 365 ? 95.462  84.475  82.347  1.00 57.63  ? 357 ASN A ND2   1 
ATOM   1762  N  N     . VAL A 1 366 ? 100.348 85.852  83.151  1.00 64.42  ? 358 VAL A N     1 
ATOM   1763  C  CA    . VAL A 1 366 ? 101.393 85.005  83.715  1.00 64.04  ? 358 VAL A CA    1 
ATOM   1764  C  C     . VAL A 1 366 ? 100.837 84.407  85.001  1.00 66.46  ? 358 VAL A C     1 
ATOM   1765  O  O     . VAL A 1 366 ? 100.809 85.063  86.044  1.00 69.67  ? 358 VAL A O     1 
ATOM   1766  C  CB    . VAL A 1 366 ? 102.684 85.788  83.966  1.00 59.72  ? 358 VAL A CB    1 
ATOM   1767  C  CG1   . VAL A 1 366 ? 103.745 84.885  84.568  1.00 68.65  ? 358 VAL A CG1   1 
ATOM   1768  C  CG2   . VAL A 1 366 ? 103.182 86.407  82.677  1.00 63.14  ? 358 VAL A CG2   1 
ATOM   1769  N  N     . GLN A 1 367 ? 100.401 83.154  84.933  1.00 65.59  ? 359 GLN A N     1 
ATOM   1770  C  CA    . GLN A 1 367 ? 99.778  82.485  86.069  1.00 65.70  ? 359 GLN A CA    1 
ATOM   1771  C  C     . GLN A 1 367 ? 100.868 81.865  86.935  1.00 78.18  ? 359 GLN A C     1 
ATOM   1772  O  O     . GLN A 1 367 ? 101.519 80.897  86.529  1.00 86.33  ? 359 GLN A O     1 
ATOM   1773  C  CB    . GLN A 1 367 ? 98.793  81.424  85.591  1.00 69.85  ? 359 GLN A CB    1 
ATOM   1774  C  CG    . GLN A 1 367 ? 97.922  81.871  84.436  1.00 75.66  ? 359 GLN A CG    1 
ATOM   1775  C  CD    . GLN A 1 367 ? 97.047  80.755  83.907  1.00 86.10  ? 359 GLN A CD    1 
ATOM   1776  O  OE1   . GLN A 1 367 ? 96.440  80.010  84.676  1.00 90.14  ? 359 GLN A OE1   1 
ATOM   1777  N  NE2   . GLN A 1 367 ? 96.986  80.626  82.587  1.00 86.60  ? 359 GLN A NE2   1 
ATOM   1778  N  N     . LEU A 1 368 ? 101.067 82.420  88.125  1.00 80.45  ? 360 LEU A N     1 
ATOM   1779  C  CA    . LEU A 1 368 ? 102.034 81.884  89.082  1.00 80.85  ? 360 LEU A CA    1 
ATOM   1780  C  C     . LEU A 1 368 ? 101.378 80.889  90.034  1.00 90.06  ? 360 LEU A C     1 
ATOM   1781  O  O     . LEU A 1 368 ? 101.483 81.008  91.252  1.00 94.10  ? 360 LEU A O     1 
ATOM   1782  C  CB    . LEU A 1 368 ? 102.689 83.023  89.853  1.00 74.06  ? 360 LEU A CB    1 
ATOM   1783  C  CG    . LEU A 1 368 ? 103.354 84.123  89.029  1.00 71.39  ? 360 LEU A CG    1 
ATOM   1784  C  CD1   . LEU A 1 368 ? 103.973 85.164  89.945  1.00 69.72  ? 360 LEU A CD1   1 
ATOM   1785  C  CD2   . LEU A 1 368 ? 104.397 83.536  88.097  1.00 75.49  ? 360 LEU A CD2   1 
ATOM   1786  N  N     . SER A 1 369 ? 100.690 79.895  89.479  1.00 94.14  ? 361 SER A N     1 
ATOM   1787  C  CA    . SER A 1 369 ? 99.990  78.916  90.294  1.00 100.73 ? 361 SER A CA    1 
ATOM   1788  C  C     . SER A 1 369 ? 100.943 77.800  90.714  1.00 115.60 ? 361 SER A C     1 
ATOM   1789  O  O     . SER A 1 369 ? 102.123 77.781  90.356  1.00 116.18 ? 361 SER A O     1 
ATOM   1790  C  CB    . SER A 1 369 ? 98.788  78.356  89.537  1.00 97.05  ? 361 SER A CB    1 
ATOM   1791  O  OG    . SER A 1 369 ? 99.199  77.650  88.380  1.00 104.62 ? 361 SER A OG    1 
ATOM   1792  N  N     . ASP A 1 370 ? 100.420 76.855  91.491  1.00 122.00 ? 362 ASP A N     1 
ATOM   1793  C  CA    . ASP A 1 370 ? 101.223 75.726  91.938  1.00 124.52 ? 362 ASP A CA    1 
ATOM   1794  C  C     . ASP A 1 370 ? 101.553 74.812  90.764  1.00 125.97 ? 362 ASP A C     1 
ATOM   1795  O  O     . ASP A 1 370 ? 100.707 74.549  89.905  1.00 123.30 ? 362 ASP A O     1 
ATOM   1796  C  CB    . ASP A 1 370 ? 100.482 74.944  93.023  1.00 123.86 ? 362 ASP A CB    1 
ATOM   1797  C  CG    . ASP A 1 370 ? 100.086 75.815  94.199  1.00 121.97 ? 362 ASP A CG    1 
ATOM   1798  O  OD1   . ASP A 1 370 ? 100.808 76.793  94.486  1.00 120.98 ? 362 ASP A OD1   1 
ATOM   1799  O  OD2   . ASP A 1 370 ? 99.052  75.523  94.836  1.00 119.93 ? 362 ASP A OD2   1 
ATOM   1800  N  N     . HIS A 1 371 ? 102.797 74.328  90.737  1.00 129.11 ? 363 HIS A N     1 
ATOM   1801  C  CA    . HIS A 1 371 ? 103.283 73.453  89.669  1.00 129.68 ? 363 HIS A CA    1 
ATOM   1802  C  C     . HIS A 1 371 ? 103.080 74.094  88.298  1.00 128.92 ? 363 HIS A C     1 
ATOM   1803  O  O     . HIS A 1 371 ? 102.665 73.441  87.337  1.00 131.82 ? 363 HIS A O     1 
ATOM   1804  C  CB    . HIS A 1 371 ? 102.610 72.080  89.731  1.00 130.46 ? 363 HIS A CB    1 
ATOM   1805  C  CG    . HIS A 1 371 ? 102.696 71.423  91.073  1.00 133.38 ? 363 HIS A CG    1 
ATOM   1806  N  ND1   . HIS A 1 371 ? 103.758 70.628  91.446  1.00 134.21 ? 363 HIS A ND1   1 
ATOM   1807  C  CD2   . HIS A 1 371 ? 101.849 71.438  92.130  1.00 135.14 ? 363 HIS A CD2   1 
ATOM   1808  C  CE1   . HIS A 1 371 ? 103.564 70.184  92.675  1.00 134.91 ? 363 HIS A CE1   1 
ATOM   1809  N  NE2   . HIS A 1 371 ? 102.412 70.661  93.112  1.00 135.28 ? 363 HIS A NE2   1 
ATOM   1810  N  N     . THR A 1 372 ? 103.367 75.395  88.210  1.00 123.95 ? 364 THR A N     1 
ATOM   1811  C  CA    . THR A 1 372 ? 103.152 76.114  86.959  1.00 123.06 ? 364 THR A CA    1 
ATOM   1812  C  C     . THR A 1 372 ? 104.093 75.622  85.863  1.00 130.36 ? 364 THR A C     1 
ATOM   1813  O  O     . THR A 1 372 ? 103.651 75.343  84.742  1.00 130.21 ? 364 THR A O     1 
ATOM   1814  C  CB    . THR A 1 372 ? 103.316 77.618  87.184  1.00 114.36 ? 364 THR A CB    1 
ATOM   1815  O  OG1   . THR A 1 372 ? 103.396 78.291  85.921  1.00 115.08 ? 364 THR A OG1   1 
ATOM   1816  C  CG2   . THR A 1 372 ? 104.567 77.912  88.003  1.00 112.23 ? 364 THR A CG2   1 
ATOM   1817  N  N     . ARG A 1 373 ? 105.387 75.504  86.171  1.00 131.12 ? 365 ARG A N     1 
ATOM   1818  C  CA    . ARG A 1 373 ? 106.393 75.006  85.236  1.00 129.40 ? 365 ARG A CA    1 
ATOM   1819  C  C     . ARG A 1 373 ? 106.366 75.761  83.913  1.00 129.68 ? 365 ARG A C     1 
ATOM   1820  O  O     . ARG A 1 373 ? 106.550 75.163  82.849  1.00 130.07 ? 365 ARG A O     1 
ATOM   1821  C  CB    . ARG A 1 373 ? 106.199 73.509  84.989  1.00 131.28 ? 365 ARG A CB    1 
ATOM   1822  C  CG    . ARG A 1 373 ? 106.341 72.650  86.233  1.00 137.00 ? 365 ARG A CG    1 
ATOM   1823  C  CD    . ARG A 1 373 ? 106.187 71.174  85.901  1.00 145.58 ? 365 ARG A CD    1 
ATOM   1824  N  NE    . ARG A 1 373 ? 106.427 70.322  87.060  1.00 152.19 ? 365 ARG A NE    1 
ATOM   1825  C  CZ    . ARG A 1 373 ? 106.444 68.997  87.026  1.00 152.81 ? 365 ARG A CZ    1 
ATOM   1826  N  NH1   . ARG A 1 373 ? 106.237 68.332  85.901  1.00 152.20 ? 365 ARG A NH1   1 
ATOM   1827  N  NH2   . ARG A 1 373 ? 106.677 68.321  88.147  1.00 152.40 ? 365 ARG A NH2   1 
ATOM   1828  N  N     . SER A 1 374 ? 106.136 77.074  83.968  1.00 129.30 ? 366 SER A N     1 
ATOM   1829  C  CA    . SER A 1 374 ? 106.053 77.910  82.776  1.00 124.97 ? 366 SER A CA    1 
ATOM   1830  C  C     . SER A 1 374 ? 107.261 78.823  82.611  1.00 123.66 ? 366 SER A C     1 
ATOM   1831  O  O     . SER A 1 374 ? 107.103 79.977  82.191  1.00 121.88 ? 366 SER A O     1 
ATOM   1832  C  CB    . SER A 1 374 ? 104.765 78.733  82.802  1.00 119.40 ? 366 SER A CB    1 
ATOM   1833  O  OG    . SER A 1 374 ? 104.726 79.579  83.937  1.00 115.25 ? 366 SER A OG    1 
ATOM   1834  N  N     . GLU A 1 375 ? 108.462 78.335  82.932  1.00 124.63 ? 367 GLU A N     1 
ATOM   1835  C  CA    . GLU A 1 375 ? 109.650 79.182  82.881  1.00 124.62 ? 367 GLU A CA    1 
ATOM   1836  C  C     . GLU A 1 375 ? 109.886 79.747  81.487  1.00 123.38 ? 367 GLU A C     1 
ATOM   1837  O  O     . GLU A 1 375 ? 110.380 80.871  81.348  1.00 122.34 ? 367 GLU A O     1 
ATOM   1838  C  CB    . GLU A 1 375 ? 110.874 78.393  83.346  1.00 127.40 ? 367 GLU A CB    1 
ATOM   1839  C  CG    . GLU A 1 375 ? 110.627 77.520  84.569  1.00 128.71 ? 367 GLU A CG    1 
ATOM   1840  C  CD    . GLU A 1 375 ? 110.260 78.322  85.803  1.00 131.61 ? 367 GLU A CD    1 
ATOM   1841  O  OE1   . GLU A 1 375 ? 110.674 79.497  85.901  1.00 130.64 ? 367 GLU A OE1   1 
ATOM   1842  O  OE2   . GLU A 1 375 ? 109.553 77.776  86.677  1.00 131.84 ? 367 GLU A OE2   1 
ATOM   1843  N  N     . GLN A 1 376 ? 109.544 78.986  80.445  1.00 125.99 ? 368 GLN A N     1 
ATOM   1844  C  CA    . GLN A 1 376 ? 109.724 79.474  79.082  1.00 126.36 ? 368 GLN A CA    1 
ATOM   1845  C  C     . GLN A 1 376 ? 108.823 80.670  78.799  1.00 121.09 ? 368 GLN A C     1 
ATOM   1846  O  O     . GLN A 1 376 ? 109.199 81.575  78.045  1.00 117.91 ? 368 GLN A O     1 
ATOM   1847  C  CB    . GLN A 1 376 ? 109.453 78.348  78.085  1.00 129.84 ? 368 GLN A CB    1 
ATOM   1848  C  CG    . GLN A 1 376 ? 110.368 77.146  78.248  1.00 135.45 ? 368 GLN A CG    1 
ATOM   1849  C  CD    . GLN A 1 376 ? 110.029 76.020  77.291  1.00 144.04 ? 368 GLN A CD    1 
ATOM   1850  O  OE1   . GLN A 1 376 ? 109.006 76.057  76.608  1.00 148.57 ? 368 GLN A OE1   1 
ATOM   1851  N  NE2   . GLN A 1 376 ? 110.891 75.012  77.235  1.00 141.45 ? 368 GLN A NE2   1 
ATOM   1852  N  N     . CYS A 1 377 ? 107.627 80.687  79.392  1.00 120.56 ? 369 CYS A N     1 
ATOM   1853  C  CA    . CYS A 1 377 ? 106.686 81.772  79.135  1.00 118.00 ? 369 CYS A CA    1 
ATOM   1854  C  C     . CYS A 1 377 ? 107.235 83.112  79.608  1.00 115.51 ? 369 CYS A C     1 
ATOM   1855  O  O     . CYS A 1 377 ? 107.120 84.121  78.903  1.00 111.34 ? 369 CYS A O     1 
ATOM   1856  C  CB    . CYS A 1 377 ? 105.347 81.472  79.808  1.00 114.95 ? 369 CYS A CB    1 
ATOM   1857  S  SG    . CYS A 1 377 ? 104.596 79.908  79.300  1.00 120.42 ? 369 CYS A SG    1 
ATOM   1858  N  N     . TYR A 1 378 ? 107.839 83.145  80.796  1.00 116.74 ? 370 TYR A N     1 
ATOM   1859  C  CA    . TYR A 1 378 ? 108.408 84.370  81.344  1.00 115.22 ? 370 TYR A CA    1 
ATOM   1860  C  C     . TYR A 1 378 ? 109.932 84.321  81.401  1.00 120.61 ? 370 TYR A C     1 
ATOM   1861  O  O     . TYR A 1 378 ? 110.543 84.908  82.297  1.00 119.67 ? 370 TYR A O     1 
ATOM   1862  C  CB    . TYR A 1 378 ? 107.828 84.667  82.727  1.00 107.91 ? 370 TYR A CB    1 
ATOM   1863  C  CG    . TYR A 1 378 ? 107.934 83.537  83.727  1.00 110.36 ? 370 TYR A CG    1 
ATOM   1864  C  CD1   . TYR A 1 378 ? 109.071 83.377  84.507  1.00 114.31 ? 370 TYR A CD1   1 
ATOM   1865  C  CD2   . TYR A 1 378 ? 106.886 82.647  83.909  1.00 111.35 ? 370 TYR A CD2   1 
ATOM   1866  C  CE1   . TYR A 1 378 ? 109.167 82.352  85.427  1.00 118.54 ? 370 TYR A CE1   1 
ATOM   1867  C  CE2   . TYR A 1 378 ? 106.972 81.621  84.829  1.00 114.28 ? 370 TYR A CE2   1 
ATOM   1868  C  CZ    . TYR A 1 378 ? 108.114 81.477  85.584  1.00 118.53 ? 370 TYR A CZ    1 
ATOM   1869  O  OH    . TYR A 1 378 ? 108.203 80.456  86.501  1.00 121.37 ? 370 TYR A OH    1 
ATOM   1870  N  N     . ARG A 1 379 ? 110.555 83.618  80.451  1.00 123.78 ? 371 ARG A N     1 
ATOM   1871  C  CA    . ARG A 1 379 ? 112.013 83.595  80.375  1.00 124.61 ? 371 ARG A CA    1 
ATOM   1872  C  C     . ARG A 1 379 ? 112.592 84.997  80.240  1.00 122.68 ? 371 ARG A C     1 
ATOM   1873  O  O     . ARG A 1 379 ? 113.687 85.269  80.744  1.00 122.16 ? 371 ARG A O     1 
ATOM   1874  C  CB    . ARG A 1 379 ? 112.460 82.719  79.203  1.00 124.09 ? 371 ARG A CB    1 
ATOM   1875  C  CG    . ARG A 1 379 ? 113.948 82.399  79.183  1.00 129.62 ? 371 ARG A CG    1 
ATOM   1876  C  CD    . ARG A 1 379 ? 114.250 81.069  79.865  1.00 130.68 ? 371 ARG A CD    1 
ATOM   1877  N  NE    . ARG A 1 379 ? 113.871 81.063  81.273  1.00 131.75 ? 371 ARG A NE    1 
ATOM   1878  C  CZ    . ARG A 1 379 ? 114.675 81.415  82.267  1.00 130.16 ? 371 ARG A CZ    1 
ATOM   1879  N  NH1   . ARG A 1 379 ? 115.917 81.810  82.045  1.00 129.23 ? 371 ARG A NH1   1 
ATOM   1880  N  NH2   . ARG A 1 379 ? 114.220 81.368  83.516  1.00 127.03 ? 371 ARG A NH2   1 
ATOM   1881  N  N     . ASP A 1 380 ? 111.877 85.898  79.565  1.00 119.29 ? 372 ASP A N     1 
ATOM   1882  C  CA    . ASP A 1 380 ? 112.285 87.298  79.460  1.00 116.68 ? 372 ASP A CA    1 
ATOM   1883  C  C     . ASP A 1 380 ? 111.515 88.102  80.504  1.00 117.11 ? 372 ASP A C     1 
ATOM   1884  O  O     . ASP A 1 380 ? 110.496 88.740  80.227  1.00 116.77 ? 372 ASP A O     1 
ATOM   1885  C  CB    . ASP A 1 380 ? 112.050 87.818  78.048  1.00 114.84 ? 372 ASP A CB    1 
ATOM   1886  C  CG    . ASP A 1 380 ? 110.684 87.439  77.507  1.00 114.08 ? 372 ASP A CG    1 
ATOM   1887  O  OD1   . ASP A 1 380 ? 110.160 86.377  77.904  1.00 111.43 ? 372 ASP A OD1   1 
ATOM   1888  O  OD2   . ASP A 1 380 ? 110.135 88.203  76.685  1.00 113.55 ? 372 ASP A OD2   1 
ATOM   1889  N  N     . VAL A 1 381 ? 112.022 88.064  81.740  1.00 115.96 ? 373 VAL A N     1 
ATOM   1890  C  CA    . VAL A 1 381 ? 111.358 88.754  82.844  1.00 113.62 ? 373 VAL A CA    1 
ATOM   1891  C  C     . VAL A 1 381 ? 111.352 90.259  82.624  1.00 112.20 ? 373 VAL A C     1 
ATOM   1892  O  O     . VAL A 1 381 ? 110.498 90.970  83.167  1.00 110.62 ? 373 VAL A O     1 
ATOM   1893  C  CB    . VAL A 1 381 ? 112.022 88.386  84.186  1.00 109.29 ? 373 VAL A CB    1 
ATOM   1894  C  CG1   . VAL A 1 381 ? 111.831 86.910  84.489  1.00 109.45 ? 373 VAL A CG1   1 
ATOM   1895  C  CG2   . VAL A 1 381 ? 113.501 88.745  84.166  1.00 110.71 ? 373 VAL A CG2   1 
ATOM   1896  N  N     . SER A 1 382 ? 112.299 90.771  81.835  1.00 115.39 ? 374 SER A N     1 
ATOM   1897  C  CA    . SER A 1 382 ? 112.366 92.209  81.594  1.00 113.45 ? 374 SER A CA    1 
ATOM   1898  C  C     . SER A 1 382 ? 111.134 92.706  80.848  1.00 109.28 ? 374 SER A C     1 
ATOM   1899  O  O     . SER A 1 382 ? 110.668 93.827  81.083  1.00 107.23 ? 374 SER A O     1 
ATOM   1900  C  CB    . SER A 1 382 ? 113.637 92.550  80.816  1.00 117.03 ? 374 SER A CB    1 
ATOM   1901  O  OG    . SER A 1 382 ? 113.662 91.886  79.565  1.00 118.25 ? 374 SER A OG    1 
ATOM   1902  N  N     . ASP A 1 383 ? 110.593 91.890  79.946  1.00 109.48 ? 375 ASP A N     1 
ATOM   1903  C  CA    . ASP A 1 383 ? 109.470 92.273  79.098  1.00 107.57 ? 375 ASP A CA    1 
ATOM   1904  C  C     . ASP A 1 383 ? 108.184 91.552  79.493  1.00 100.19 ? 375 ASP A C     1 
ATOM   1905  O  O     . ASP A 1 383 ? 107.393 91.149  78.639  1.00 92.32  ? 375 ASP A O     1 
ATOM   1906  C  CB    . ASP A 1 383 ? 109.792 92.014  77.629  1.00 114.30 ? 375 ASP A CB    1 
ATOM   1907  C  CG    . ASP A 1 383 ? 110.958 92.847  77.133  1.00 119.32 ? 375 ASP A CG    1 
ATOM   1908  O  OD1   . ASP A 1 383 ? 112.111 92.535  77.499  1.00 121.65 ? 375 ASP A OD1   1 
ATOM   1909  O  OD2   . ASP A 1 383 ? 110.721 93.813  76.377  1.00 118.57 ? 375 ASP A OD2   1 
ATOM   1910  N  N     . LEU A 1 384 ? 107.965 91.374  80.794  1.00 101.28 ? 376 LEU A N     1 
ATOM   1911  C  CA    . LEU A 1 384 ? 106.717 90.801  81.277  1.00 93.85  ? 376 LEU A CA    1 
ATOM   1912  C  C     . LEU A 1 384 ? 105.690 91.904  81.502  1.00 84.29  ? 376 LEU A C     1 
ATOM   1913  O  O     . LEU A 1 384 ? 106.036 93.026  81.884  1.00 80.69  ? 376 LEU A O     1 
ATOM   1914  C  CB    . LEU A 1 384 ? 106.947 90.019  82.568  1.00 91.88  ? 376 LEU A CB    1 
ATOM   1915  C  CG    . LEU A 1 384 ? 106.088 88.762  82.684  1.00 82.51  ? 376 LEU A CG    1 
ATOM   1916  C  CD1   . LEU A 1 384 ? 106.373 87.838  81.514  1.00 87.12  ? 376 LEU A CD1   1 
ATOM   1917  C  CD2   . LEU A 1 384 ? 106.337 88.053  83.999  1.00 78.60  ? 376 LEU A CD2   1 
ATOM   1918  N  N     . LYS A 1 385 ? 104.418 91.582  81.262  1.00 79.48  ? 377 LYS A N     1 
ATOM   1919  C  CA    . LYS A 1 385 ? 103.367 92.591  81.204  1.00 74.45  ? 377 LYS A CA    1 
ATOM   1920  C  C     . LYS A 1 385 ? 102.320 92.439  82.301  1.00 72.75  ? 377 LYS A C     1 
ATOM   1921  O  O     . LYS A 1 385 ? 102.113 93.368  83.087  1.00 65.38  ? 377 LYS A O     1 
ATOM   1922  C  CB    . LYS A 1 385 ? 102.709 92.551  79.820  1.00 69.21  ? 377 LYS A CB    1 
ATOM   1923  C  CG    . LYS A 1 385 ? 103.658 92.930  78.697  1.00 74.11  ? 377 LYS A CG    1 
ATOM   1924  C  CD    . LYS A 1 385 ? 102.944 93.039  77.365  1.00 73.73  ? 377 LYS A CD    1 
ATOM   1925  C  CE    . LYS A 1 385 ? 103.894 93.508  76.276  1.00 75.67  ? 377 LYS A CE    1 
ATOM   1926  N  NZ    . LYS A 1 385 ? 103.211 93.648  74.961  1.00 80.63  ? 377 LYS A NZ    1 
ATOM   1927  N  N     . VAL A 1 386 ? 101.645 91.294  82.380  1.00 70.52  ? 378 VAL A N     1 
ATOM   1928  C  CA    . VAL A 1 386 ? 100.529 91.102  83.299  1.00 61.48  ? 378 VAL A CA    1 
ATOM   1929  C  C     . VAL A 1 386 ? 100.770 89.838  84.110  1.00 59.32  ? 378 VAL A C     1 
ATOM   1930  O  O     . VAL A 1 386 ? 101.070 88.780  83.545  1.00 61.92  ? 378 VAL A O     1 
ATOM   1931  C  CB    . VAL A 1 386 ? 99.185  91.020  82.552  1.00 61.64  ? 378 VAL A CB    1 
ATOM   1932  C  CG1   . VAL A 1 386 ? 98.062  90.658  83.507  1.00 60.14  ? 378 VAL A CG1   1 
ATOM   1933  C  CG2   . VAL A 1 386 ? 98.888  92.333  81.850  1.00 62.11  ? 378 VAL A CG2   1 
ATOM   1934  N  N     . ILE A 1 387 ? 100.625 89.944  85.428  1.00 55.04  ? 379 ILE A N     1 
ATOM   1935  C  CA    . ILE A 1 387 ? 100.901 88.854  86.355  1.00 53.00  ? 379 ILE A CA    1 
ATOM   1936  C  C     . ILE A 1 387 ? 99.607  88.481  87.062  1.00 51.80  ? 379 ILE A C     1 
ATOM   1937  O  O     . ILE A 1 387 ? 98.862  89.359  87.509  1.00 59.35  ? 379 ILE A O     1 
ATOM   1938  C  CB    . ILE A 1 387 ? 101.985 89.243  87.375  1.00 54.34  ? 379 ILE A CB    1 
ATOM   1939  C  CG1   . ILE A 1 387 ? 103.227 89.766  86.654  1.00 60.24  ? 379 ILE A CG1   1 
ATOM   1940  C  CG2   . ILE A 1 387 ? 102.335 88.060  88.256  1.00 58.47  ? 379 ILE A CG2   1 
ATOM   1941  C  CD1   . ILE A 1 387 ? 104.353 90.149  87.582  1.00 68.53  ? 379 ILE A CD1   1 
ATOM   1942  N  N     . HIS A 1 388 ? 99.338  87.183  87.159  1.00 50.48  ? 380 HIS A N     1 
ATOM   1943  C  CA    . HIS A 1 388 ? 98.167  86.670  87.856  1.00 52.36  ? 380 HIS A CA    1 
ATOM   1944  C  C     . HIS A 1 388 ? 98.634  85.914  89.092  1.00 55.69  ? 380 HIS A C     1 
ATOM   1945  O  O     . HIS A 1 388 ? 99.393  84.945  88.980  1.00 63.68  ? 380 HIS A O     1 
ATOM   1946  C  CB    . HIS A 1 388 ? 97.341  85.767  86.940  1.00 54.53  ? 380 HIS A CB    1 
ATOM   1947  C  CG    . HIS A 1 388 ? 96.009  85.386  87.503  1.00 54.35  ? 380 HIS A CG    1 
ATOM   1948  N  ND1   . HIS A 1 388 ? 95.157  84.510  86.865  1.00 57.00  ? 380 HIS A ND1   1 
ATOM   1949  C  CD2   . HIS A 1 388 ? 95.379  85.761  88.640  1.00 52.99  ? 380 HIS A CD2   1 
ATOM   1950  C  CE1   . HIS A 1 388 ? 94.061  84.361  87.587  1.00 59.35  ? 380 HIS A CE1   1 
ATOM   1951  N  NE2   . HIS A 1 388 ? 94.170  85.110  88.669  1.00 49.65  ? 380 HIS A NE2   1 
ATOM   1952  N  N     . TRP A 1 389 ? 98.185  86.355  90.261  1.00 57.96  ? 381 TRP A N     1 
ATOM   1953  C  CA    . TRP A 1 389 ? 98.582  85.743  91.529  1.00 61.07  ? 381 TRP A CA    1 
ATOM   1954  C  C     . TRP A 1 389 ? 97.532  84.732  91.986  1.00 67.81  ? 381 TRP A C     1 
ATOM   1955  O  O     . TRP A 1 389 ? 96.903  84.871  93.034  1.00 69.28  ? 381 TRP A O     1 
ATOM   1956  C  CB    . TRP A 1 389 ? 98.806  86.819  92.587  1.00 57.20  ? 381 TRP A CB    1 
ATOM   1957  C  CG    . TRP A 1 389 ? 99.670  87.942  92.125  1.00 56.44  ? 381 TRP A CG    1 
ATOM   1958  C  CD1   . TRP A 1 389 ? 99.265  89.078  91.492  1.00 57.14  ? 381 TRP A CD1   1 
ATOM   1959  C  CD2   . TRP A 1 389 ? 101.090 88.043  92.261  1.00 59.09  ? 381 TRP A CD2   1 
ATOM   1960  N  NE1   . TRP A 1 389 ? 100.345 89.881  91.224  1.00 57.95  ? 381 TRP A NE1   1 
ATOM   1961  C  CE2   . TRP A 1 389 ? 101.479 89.268  91.686  1.00 61.09  ? 381 TRP A CE2   1 
ATOM   1962  C  CE3   . TRP A 1 389 ? 102.072 87.216  92.814  1.00 61.35  ? 381 TRP A CE3   1 
ATOM   1963  C  CZ2   . TRP A 1 389 ? 102.805 89.686  91.646  1.00 65.02  ? 381 TRP A CZ2   1 
ATOM   1964  C  CZ3   . TRP A 1 389 ? 103.388 87.634  92.774  1.00 66.43  ? 381 TRP A CZ3   1 
ATOM   1965  C  CH2   . TRP A 1 389 ? 103.743 88.856  92.194  1.00 68.59  ? 381 TRP A CH2   1 
ATOM   1966  N  N     . ASN A 1 390 ? 97.352  83.692  91.174  1.00 66.93  ? 382 ASN A N     1 
ATOM   1967  C  CA    . ASN A 1 390 ? 96.379  82.648  91.457  1.00 73.41  ? 382 ASN A CA    1 
ATOM   1968  C  C     . ASN A 1 390 ? 96.943  81.544  92.342  1.00 87.40  ? 382 ASN A C     1 
ATOM   1969  O  O     . ASN A 1 390 ? 96.367  80.452  92.398  1.00 92.58  ? 382 ASN A O     1 
ATOM   1970  C  CB    . ASN A 1 390 ? 95.846  82.057  90.151  1.00 73.93  ? 382 ASN A CB    1 
ATOM   1971  C  CG    . ASN A 1 390 ? 96.951  81.588  89.230  1.00 80.33  ? 382 ASN A CG    1 
ATOM   1972  O  OD1   . ASN A 1 390 ? 98.078  82.077  89.296  1.00 81.16  ? 382 ASN A OD1   1 
ATOM   1973  N  ND2   . ASN A 1 390 ? 96.631  80.639  88.358  1.00 81.04  ? 382 ASN A ND2   1 
ATOM   1974  N  N     . SER A 1 391 ? 98.048  81.805  93.038  1.00 90.03  ? 383 SER A N     1 
ATOM   1975  C  CA    . SER A 1 391 ? 98.646  80.814  93.920  1.00 95.46  ? 383 SER A CA    1 
ATOM   1976  C  C     . SER A 1 391 ? 97.918  80.816  95.256  1.00 102.29 ? 383 SER A C     1 
ATOM   1977  O  O     . SER A 1 391 ? 97.863  81.863  95.916  1.00 105.09 ? 383 SER A O     1 
ATOM   1978  C  CB    . SER A 1 391 ? 100.120 81.107  94.135  1.00 95.48  ? 383 SER A CB    1 
ATOM   1979  O  OG    . SER A 1 391 ? 100.707 80.154  95.002  1.00 102.32 ? 383 SER A OG    1 
ATOM   1980  N  N     . PRO A 1 392 ? 97.345  79.684  95.693  1.00 105.30 ? 384 PRO A N     1 
ATOM   1981  C  CA    . PRO A 1 392 ? 96.642  79.585  96.976  1.00 104.90 ? 384 PRO A CA    1 
ATOM   1982  C  C     . PRO A 1 392 ? 97.559  79.846  98.167  1.00 105.43 ? 384 PRO A C     1 
ATOM   1983  O  O     . PRO A 1 392 ? 97.119  80.473  99.131  1.00 102.39 ? 384 PRO A O     1 
ATOM   1984  C  CB    . PRO A 1 392 ? 96.135  78.138  96.988  1.00 104.06 ? 384 PRO A CB    1 
ATOM   1985  C  CG    . PRO A 1 392 ? 96.105  77.730  95.553  1.00 104.10 ? 384 PRO A CG    1 
ATOM   1986  C  CD    . PRO A 1 392 ? 97.264  78.432  94.923  1.00 104.99 ? 384 PRO A CD    1 
ATOM   1987  N  N     . GLU A 1 403 ? 111.991 86.243  92.723  1.00 78.39  ? 395 GLU A N     1 
ATOM   1988  C  CA    . GLU A 1 403 ? 112.302 87.416  93.530  1.00 91.61  ? 395 GLU A CA    1 
ATOM   1989  C  C     . GLU A 1 403 ? 111.826 88.693  92.846  1.00 91.37  ? 395 GLU A C     1 
ATOM   1990  O  O     . GLU A 1 403 ? 111.337 89.619  93.502  1.00 94.37  ? 395 GLU A O     1 
ATOM   1991  C  CB    . GLU A 1 403 ? 113.804 87.494  93.806  1.00 94.07  ? 395 GLU A CB    1 
ATOM   1992  C  CG    . GLU A 1 403 ? 114.221 88.711  94.613  1.00 99.35  ? 395 GLU A CG    1 
ATOM   1993  C  CD    . GLU A 1 403 ? 115.700 88.716  94.940  1.00 106.26 ? 395 GLU A CD    1 
ATOM   1994  O  OE1   . GLU A 1 403 ? 116.326 87.637  94.886  1.00 109.01 ? 395 GLU A OE1   1 
ATOM   1995  O  OE2   . GLU A 1 403 ? 116.237 89.801  95.247  1.00 110.67 ? 395 GLU A OE2   1 
ATOM   1996  N  N     . PHE A 1 404 ? 111.972 88.736  91.520  1.00 87.36  ? 396 PHE A N     1 
ATOM   1997  C  CA    . PHE A 1 404 ? 111.498 89.891  90.767  1.00 91.40  ? 396 PHE A CA    1 
ATOM   1998  C  C     . PHE A 1 404 ? 109.990 90.046  90.894  1.00 89.66  ? 396 PHE A C     1 
ATOM   1999  O  O     . PHE A 1 404 ? 109.482 91.165  91.013  1.00 85.90  ? 396 PHE A O     1 
ATOM   2000  C  CB    . PHE A 1 404 ? 111.902 89.772  89.298  1.00 92.38  ? 396 PHE A CB    1 
ATOM   2001  C  CG    . PHE A 1 404 ? 111.366 90.879  88.433  1.00 97.08  ? 396 PHE A CG    1 
ATOM   2002  C  CD1   . PHE A 1 404 ? 111.973 92.123  88.424  1.00 97.41  ? 396 PHE A CD1   1 
ATOM   2003  C  CD2   . PHE A 1 404 ? 110.255 90.675  87.631  1.00 97.27  ? 396 PHE A CD2   1 
ATOM   2004  C  CE1   . PHE A 1 404 ? 111.482 93.143  87.632  1.00 96.49  ? 396 PHE A CE1   1 
ATOM   2005  C  CE2   . PHE A 1 404 ? 109.759 91.691  86.838  1.00 93.56  ? 396 PHE A CE2   1 
ATOM   2006  C  CZ    . PHE A 1 404 ? 110.374 92.926  86.838  1.00 93.35  ? 396 PHE A CZ    1 
ATOM   2007  N  N     . PHE A 1 405 ? 109.255 88.932  90.864  1.00 88.71  ? 397 PHE A N     1 
ATOM   2008  C  CA    . PHE A 1 405 ? 107.808 88.996  91.038  1.00 86.27  ? 397 PHE A CA    1 
ATOM   2009  C  C     . PHE A 1 405 ? 107.443 89.518  92.420  1.00 84.17  ? 397 PHE A C     1 
ATOM   2010  O  O     . PHE A 1 405 ? 106.518 90.325  92.563  1.00 83.38  ? 397 PHE A O     1 
ATOM   2011  C  CB    . PHE A 1 405 ? 107.189 87.620  90.800  1.00 82.86  ? 397 PHE A CB    1 
ATOM   2012  C  CG    . PHE A 1 405 ? 107.410 87.089  89.415  1.00 84.68  ? 397 PHE A CG    1 
ATOM   2013  C  CD1   . PHE A 1 405 ? 107.649 87.950  88.359  1.00 87.77  ? 397 PHE A CD1   1 
ATOM   2014  C  CD2   . PHE A 1 405 ? 107.381 85.727  89.169  1.00 86.69  ? 397 PHE A CD2   1 
ATOM   2015  C  CE1   . PHE A 1 405 ? 107.856 87.465  87.087  1.00 92.67  ? 397 PHE A CE1   1 
ATOM   2016  C  CE2   . PHE A 1 405 ? 107.585 85.236  87.896  1.00 93.50  ? 397 PHE A CE2   1 
ATOM   2017  C  CZ    . PHE A 1 405 ? 107.823 86.106  86.854  1.00 96.83  ? 397 PHE A CZ    1 
ATOM   2018  N  N     . ARG A 1 406 ? 108.159 89.066  93.452  1.00 86.83  ? 398 ARG A N     1 
ATOM   2019  C  CA    . ARG A 1 406 ? 107.896 89.547  94.804  1.00 87.22  ? 398 ARG A CA    1 
ATOM   2020  C  C     . ARG A 1 406 ? 108.156 91.044  94.913  1.00 84.68  ? 398 ARG A C     1 
ATOM   2021  O  O     . ARG A 1 406 ? 107.352 91.780  95.501  1.00 85.96  ? 398 ARG A O     1 
ATOM   2022  C  CB    . ARG A 1 406 ? 108.759 88.778  95.804  1.00 89.27  ? 398 ARG A CB    1 
ATOM   2023  C  CG    . ARG A 1 406 ? 108.161 88.652  97.195  1.00 98.64  ? 398 ARG A CG    1 
ATOM   2024  C  CD    . ARG A 1 406 ? 107.340 87.378  97.336  1.00 104.92 ? 398 ARG A CD    1 
ATOM   2025  N  NE    . ARG A 1 406 ? 106.767 87.248  98.671  1.00 116.35 ? 398 ARG A NE    1 
ATOM   2026  C  CZ    . ARG A 1 406 ? 106.210 86.142  99.146  1.00 118.34 ? 398 ARG A CZ    1 
ATOM   2027  N  NH1   . ARG A 1 406 ? 106.144 85.035  98.423  1.00 114.04 ? 398 ARG A NH1   1 
ATOM   2028  N  NH2   . ARG A 1 406 ? 105.710 86.146  100.379 1.00 120.92 ? 398 ARG A NH2   1 
ATOM   2029  N  N     . ASN A 1 407 ? 109.270 91.514  94.345  1.00 83.07  ? 399 ASN A N     1 
ATOM   2030  C  CA    . ASN A 1 407 ? 109.575 92.940  94.383  1.00 81.92  ? 399 ASN A CA    1 
ATOM   2031  C  C     . ASN A 1 407 ? 108.545 93.748  93.604  1.00 83.86  ? 399 ASN A C     1 
ATOM   2032  O  O     . ASN A 1 407 ? 108.135 94.829  94.040  1.00 84.65  ? 399 ASN A O     1 
ATOM   2033  C  CB    . ASN A 1 407 ? 110.980 93.192  93.841  1.00 85.22  ? 399 ASN A CB    1 
ATOM   2034  C  CG    . ASN A 1 407 ? 112.057 92.595  94.723  1.00 92.62  ? 399 ASN A CG    1 
ATOM   2035  O  OD1   . ASN A 1 407 ? 111.880 92.464  95.934  1.00 88.59  ? 399 ASN A OD1   1 
ATOM   2036  N  ND2   . ASN A 1 407 ? 113.183 92.231  94.120  1.00 99.38  ? 399 ASN A ND2   1 
ATOM   2037  N  N     . LEU A 1 408 ? 108.112 93.239  92.448  1.00 86.17  ? 400 LEU A N     1 
ATOM   2038  C  CA    . LEU A 1 408 ? 107.096 93.934  91.663  1.00 85.70  ? 400 LEU A CA    1 
ATOM   2039  C  C     . LEU A 1 408 ? 105.781 94.025  92.425  1.00 83.72  ? 400 LEU A C     1 
ATOM   2040  O  O     . LEU A 1 408 ? 105.114 95.066  92.406  1.00 79.08  ? 400 LEU A O     1 
ATOM   2041  C  CB    . LEU A 1 408 ? 106.902 93.221  90.323  1.00 81.45  ? 400 LEU A CB    1 
ATOM   2042  C  CG    . LEU A 1 408 ? 105.985 93.857  89.276  1.00 80.12  ? 400 LEU A CG    1 
ATOM   2043  C  CD1   . LEU A 1 408 ? 106.535 93.602  87.883  1.00 85.12  ? 400 LEU A CD1   1 
ATOM   2044  C  CD2   . LEU A 1 408 ? 104.568 93.319  89.387  1.00 77.17  ? 400 LEU A CD2   1 
ATOM   2045  N  N     . TYR A 1 409 ? 105.388 92.941  93.096  1.00 82.96  ? 401 TYR A N     1 
ATOM   2046  C  CA    . TYR A 1 409 ? 104.160 92.958  93.883  1.00 76.74  ? 401 TYR A CA    1 
ATOM   2047  C  C     . TYR A 1 409 ? 104.258 93.955  95.029  1.00 76.22  ? 401 TYR A C     1 
ATOM   2048  O  O     . TYR A 1 409 ? 103.327 94.732  95.274  1.00 73.61  ? 401 TYR A O     1 
ATOM   2049  C  CB    . TYR A 1 409 ? 103.864 91.555  94.410  1.00 76.28  ? 401 TYR A CB    1 
ATOM   2050  C  CG    . TYR A 1 409 ? 102.560 91.439  95.160  1.00 75.66  ? 401 TYR A CG    1 
ATOM   2051  C  CD1   . TYR A 1 409 ? 101.354 91.741  94.543  1.00 71.58  ? 401 TYR A CD1   1 
ATOM   2052  C  CD2   . TYR A 1 409 ? 102.532 91.008  96.478  1.00 77.73  ? 401 TYR A CD2   1 
ATOM   2053  C  CE1   . TYR A 1 409 ? 100.158 91.631  95.223  1.00 76.57  ? 401 TYR A CE1   1 
ATOM   2054  C  CE2   . TYR A 1 409 ? 101.342 90.892  97.166  1.00 76.81  ? 401 TYR A CE2   1 
ATOM   2055  C  CZ    . TYR A 1 409 ? 100.158 91.205  96.535  1.00 81.17  ? 401 TYR A CZ    1 
ATOM   2056  O  OH    . TYR A 1 409 ? 98.969  91.091  97.219  1.00 85.17  ? 401 TYR A OH    1 
ATOM   2057  N  N     . LEU A 1 410 ? 105.387 93.953  95.741  1.00 80.46  ? 402 LEU A N     1 
ATOM   2058  C  CA    . LEU A 1 410 ? 105.573 94.904  96.831  1.00 77.62  ? 402 LEU A CA    1 
ATOM   2059  C  C     . LEU A 1 410 ? 105.691 96.338  96.334  1.00 78.90  ? 402 LEU A C     1 
ATOM   2060  O  O     . LEU A 1 410 ? 105.472 97.270  97.115  1.00 78.50  ? 402 LEU A O     1 
ATOM   2061  C  CB    . LEU A 1 410 ? 106.809 94.536  97.652  1.00 77.86  ? 402 LEU A CB    1 
ATOM   2062  C  CG    . LEU A 1 410 ? 106.748 93.214  98.419  1.00 79.90  ? 402 LEU A CG    1 
ATOM   2063  C  CD1   . LEU A 1 410 ? 108.005 93.025  99.250  1.00 79.95  ? 402 LEU A CD1   1 
ATOM   2064  C  CD2   . LEU A 1 410 ? 105.508 93.154  99.297  1.00 77.65  ? 402 LEU A CD2   1 
ATOM   2065  N  N     . THR A 1 411 ? 106.046 96.534  95.063  1.00 79.29  ? 403 THR A N     1 
ATOM   2066  C  CA    . THR A 1 411 ? 106.129 97.883  94.515  1.00 77.93  ? 403 THR A CA    1 
ATOM   2067  C  C     . THR A 1 411 ? 104.767 98.566  94.528  1.00 77.43  ? 403 THR A C     1 
ATOM   2068  O  O     . THR A 1 411 ? 104.646 99.728  94.929  1.00 80.46  ? 403 THR A O     1 
ATOM   2069  C  CB    . THR A 1 411 ? 106.694 97.835  93.095  1.00 76.37  ? 403 THR A CB    1 
ATOM   2070  O  OG1   . THR A 1 411 ? 108.022 97.299  93.125  1.00 76.45  ? 403 THR A OG1   1 
ATOM   2071  C  CG2   . THR A 1 411 ? 106.725 99.227  92.483  1.00 76.97  ? 403 THR A CG2   1 
ATOM   2072  N  N     . PHE A 1 412 ? 103.726 97.853  94.101  1.00 75.78  ? 404 PHE A N     1 
ATOM   2073  C  CA    . PHE A 1 412 ? 102.386 98.424  94.069  1.00 74.15  ? 404 PHE A CA    1 
ATOM   2074  C  C     . PHE A 1 412 ? 101.628 98.218  95.370  1.00 72.75  ? 404 PHE A C     1 
ATOM   2075  O  O     . PHE A 1 412 ? 100.761 99.032  95.707  1.00 73.98  ? 404 PHE A O     1 
ATOM   2076  C  CB    . PHE A 1 412 ? 101.582 97.828  92.911  1.00 68.33  ? 404 PHE A CB    1 
ATOM   2077  C  CG    . PHE A 1 412 ? 102.252 97.967  91.579  1.00 68.49  ? 404 PHE A CG    1 
ATOM   2078  C  CD1   . PHE A 1 412 ? 102.366 99.205  90.974  1.00 67.70  ? 404 PHE A CD1   1 
ATOM   2079  C  CD2   . PHE A 1 412 ? 102.770 96.859  90.932  1.00 70.88  ? 404 PHE A CD2   1 
ATOM   2080  C  CE1   . PHE A 1 412 ? 102.985 99.336  89.749  1.00 71.18  ? 404 PHE A CE1   1 
ATOM   2081  C  CE2   . PHE A 1 412 ? 103.390 96.984  89.707  1.00 73.88  ? 404 PHE A CE2   1 
ATOM   2082  C  CZ    . PHE A 1 412 ? 103.498 98.224  89.114  1.00 74.76  ? 404 PHE A CZ    1 
ATOM   2083  N  N     . LEU A 1 413 ? 101.931 97.149  96.109  1.00 70.66  ? 405 LEU A N     1 
ATOM   2084  C  CA    . LEU A 1 413 ? 101.250 96.916  97.377  1.00 67.81  ? 405 LEU A CA    1 
ATOM   2085  C  C     . LEU A 1 413 ? 101.584 97.996  98.397  1.00 65.89  ? 405 LEU A C     1 
ATOM   2086  O  O     . LEU A 1 413 ? 100.813 98.224  99.335  1.00 64.76  ? 405 LEU A O     1 
ATOM   2087  C  CB    . LEU A 1 413 ? 101.616 95.535  97.919  1.00 70.28  ? 405 LEU A CB    1 
ATOM   2088  C  CG    . LEU A 1 413 ? 100.669 94.932  98.955  1.00 65.90  ? 405 LEU A CG    1 
ATOM   2089  C  CD1   . LEU A 1 413 ? 99.286  94.736  98.359  1.00 66.96  ? 405 LEU A CD1   1 
ATOM   2090  C  CD2   . LEU A 1 413 ? 101.215 93.617  99.483  1.00 66.55  ? 405 LEU A CD2   1 
ATOM   2091  N  N     . GLU A 1 414 ? 102.722 98.669  98.233  1.00 69.10  ? 406 GLU A N     1 
ATOM   2092  C  CA    . GLU A 1 414 ? 103.145 99.729  99.137  1.00 70.08  ? 406 GLU A CA    1 
ATOM   2093  C  C     . GLU A 1 414 ? 103.311 101.070 98.434  1.00 70.25  ? 406 GLU A C     1 
ATOM   2094  O  O     . GLU A 1 414 ? 103.892 101.993 99.013  1.00 73.87  ? 406 GLU A O     1 
ATOM   2095  C  CB    . GLU A 1 414 ? 104.450 99.339  99.832  1.00 73.51  ? 406 GLU A CB    1 
ATOM   2096  C  CG    . GLU A 1 414 ? 104.364 98.052  100.633 1.00 74.86  ? 406 GLU A CG    1 
ATOM   2097  C  CD    . GLU A 1 414 ? 105.644 97.747  101.384 1.00 83.00  ? 406 GLU A CD    1 
ATOM   2098  O  OE1   . GLU A 1 414 ? 106.606 98.536  101.264 1.00 84.73  ? 406 GLU A OE1   1 
ATOM   2099  O  OE2   . GLU A 1 414 ? 105.688 96.721  102.094 1.00 83.05  ? 406 GLU A OE2   1 
ATOM   2100  N  N     . TYR A 1 415 ? 102.823 101.200 97.203  1.00 69.09  ? 407 TYR A N     1 
ATOM   2101  C  CA    . TYR A 1 415 ? 102.927 102.457 96.476  1.00 73.26  ? 407 TYR A CA    1 
ATOM   2102  C  C     . TYR A 1 415 ? 101.923 103.469 97.011  1.00 72.48  ? 407 TYR A C     1 
ATOM   2103  O  O     . TYR A 1 415 ? 100.794 103.119 97.366  1.00 69.97  ? 407 TYR A O     1 
ATOM   2104  C  CB    . TYR A 1 415 ? 102.696 102.230 94.982  1.00 78.28  ? 407 TYR A CB    1 
ATOM   2105  C  CG    . TYR A 1 415 ? 102.861 103.472 94.138  1.00 85.84  ? 407 TYR A CG    1 
ATOM   2106  C  CD1   . TYR A 1 415 ? 104.116 104.020 93.914  1.00 86.27  ? 407 TYR A CD1   1 
ATOM   2107  C  CD2   . TYR A 1 415 ? 101.763 104.090 93.555  1.00 85.16  ? 407 TYR A CD2   1 
ATOM   2108  C  CE1   . TYR A 1 415 ? 104.273 105.153 93.140  1.00 89.20  ? 407 TYR A CE1   1 
ATOM   2109  C  CE2   . TYR A 1 415 ? 101.910 105.223 92.779  1.00 85.16  ? 407 TYR A CE2   1 
ATOM   2110  C  CZ    . TYR A 1 415 ? 103.167 105.751 92.575  1.00 89.94  ? 407 TYR A CZ    1 
ATOM   2111  O  OH    . TYR A 1 415 ? 103.319 106.879 91.803  1.00 91.37  ? 407 TYR A OH    1 
ATOM   2112  N  N     . ASP A 1 416 ? 102.341 104.731 97.063  1.00 71.95  ? 408 ASP A N     1 
ATOM   2113  C  CA    . ASP A 1 416 ? 101.471 105.794 97.551  1.00 72.13  ? 408 ASP A CA    1 
ATOM   2114  C  C     . ASP A 1 416 ? 100.425 106.129 96.495  1.00 74.72  ? 408 ASP A C     1 
ATOM   2115  O  O     . ASP A 1 416 ? 100.765 106.543 95.382  1.00 79.39  ? 408 ASP A O     1 
ATOM   2116  C  CB    . ASP A 1 416 ? 102.296 107.029 97.902  1.00 73.63  ? 408 ASP A CB    1 
ATOM   2117  C  CG    . ASP A 1 416 ? 101.467 108.120 98.548  1.00 77.63  ? 408 ASP A CG    1 
ATOM   2118  O  OD1   . ASP A 1 416 ? 100.319 107.840 98.952  1.00 78.40  ? 408 ASP A OD1   1 
ATOM   2119  O  OD2   . ASP A 1 416 ? 101.964 109.261 98.649  1.00 81.56  ? 408 ASP A OD2   1 
ATOM   2120  N  N     . GLY A 1 417 ? 99.149  105.957 96.846  1.00 67.75  ? 409 GLY A N     1 
ATOM   2121  C  CA    . GLY A 1 417 ? 98.087  106.212 95.889  1.00 63.06  ? 409 GLY A CA    1 
ATOM   2122  C  C     . GLY A 1 417 ? 97.871  107.683 95.604  1.00 64.46  ? 409 GLY A C     1 
ATOM   2123  O  O     . GLY A 1 417 ? 97.377  108.044 94.531  1.00 66.82  ? 409 GLY A O     1 
ATOM   2124  N  N     . ASN A 1 418 ? 98.239  108.553 96.546  1.00 64.81  ? 410 ASN A N     1 
ATOM   2125  C  CA    . ASN A 1 418 ? 98.070  109.986 96.337  1.00 65.15  ? 410 ASN A CA    1 
ATOM   2126  C  C     . ASN A 1 418 ? 98.979  110.519 95.239  1.00 73.14  ? 410 ASN A C     1 
ATOM   2127  O  O     . ASN A 1 418 ? 98.754  111.632 94.753  1.00 74.55  ? 410 ASN A O     1 
ATOM   2128  C  CB    . ASN A 1 418 ? 98.319  110.743 97.640  1.00 67.31  ? 410 ASN A CB    1 
ATOM   2129  C  CG    . ASN A 1 418 ? 97.383  110.312 98.748  1.00 72.66  ? 410 ASN A CG    1 
ATOM   2130  O  OD1   . ASN A 1 418 ? 96.334  109.721 98.494  1.00 71.28  ? 410 ASN A OD1   1 
ATOM   2131  N  ND2   . ASN A 1 418 ? 97.757  110.607 99.987  1.00 72.99  ? 410 ASN A ND2   1 
ATOM   2132  N  N     . LEU A 1 419 ? 99.997  109.756 94.839  1.00 77.83  ? 411 LEU A N     1 
ATOM   2133  C  CA    . LEU A 1 419 ? 100.801 110.130 93.684  1.00 74.93  ? 411 LEU A CA    1 
ATOM   2134  C  C     . LEU A 1 419 ? 100.037 109.987 92.377  1.00 70.31  ? 411 LEU A C     1 
ATOM   2135  O  O     . LEU A 1 419 ? 100.492 110.506 91.353  1.00 75.46  ? 411 LEU A O     1 
ATOM   2136  C  CB    . LEU A 1 419 ? 102.073 109.283 93.630  1.00 75.83  ? 411 LEU A CB    1 
ATOM   2137  C  CG    . LEU A 1 419 ? 102.960 109.305 94.875  1.00 80.09  ? 411 LEU A CG    1 
ATOM   2138  C  CD1   . LEU A 1 419 ? 104.236 108.514 94.634  1.00 76.47  ? 411 LEU A CD1   1 
ATOM   2139  C  CD2   . LEU A 1 419 ? 103.278 110.734 95.291  1.00 79.59  ? 411 LEU A CD2   1 
ATOM   2140  N  N     . LEU A 1 420 ? 98.895  109.302 92.389  1.00 68.79  ? 412 LEU A N     1 
ATOM   2141  C  CA    . LEU A 1 420 ? 98.076  109.131 91.197  1.00 73.36  ? 412 LEU A CA    1 
ATOM   2142  C  C     . LEU A 1 420 ? 97.145  110.308 90.944  1.00 73.79  ? 412 LEU A C     1 
ATOM   2143  O  O     . LEU A 1 420 ? 96.412  110.293 89.950  1.00 71.67  ? 412 LEU A O     1 
ATOM   2144  C  CB    . LEU A 1 420 ? 97.259  107.842 91.307  1.00 69.23  ? 412 LEU A CB    1 
ATOM   2145  C  CG    . LEU A 1 420 ? 98.077  106.571 91.529  1.00 72.18  ? 412 LEU A CG    1 
ATOM   2146  C  CD1   . LEU A 1 420 ? 97.166  105.367 91.681  1.00 67.01  ? 412 LEU A CD1   1 
ATOM   2147  C  CD2   . LEU A 1 420 ? 99.058  106.364 90.389  1.00 74.92  ? 412 LEU A CD2   1 
ATOM   2148  N  N     . ARG A 1 421 ? 97.151  111.318 91.812  1.00 73.11  ? 413 ARG A N     1 
ATOM   2149  C  CA    . ARG A 1 421 ? 96.294  112.482 91.632  1.00 73.58  ? 413 ARG A CA    1 
ATOM   2150  C  C     . ARG A 1 421 ? 96.929  113.489 90.682  1.00 78.35  ? 413 ARG A C     1 
ATOM   2151  O  O     . ARG A 1 421 ? 97.063  114.670 91.015  1.00 79.79  ? 413 ARG A O     1 
ATOM   2152  C  CB    . ARG A 1 421 ? 95.994  113.135 92.982  1.00 66.63  ? 413 ARG A CB    1 
ATOM   2153  C  CG    . ARG A 1 421 ? 95.169  112.265 93.912  1.00 63.47  ? 413 ARG A CG    1 
ATOM   2154  C  CD    . ARG A 1 421 ? 94.928  112.946 95.246  1.00 62.59  ? 413 ARG A CD    1 
ATOM   2155  N  NE    . ARG A 1 421 ? 94.013  112.181 96.083  1.00 59.39  ? 413 ARG A NE    1 
ATOM   2156  C  CZ    . ARG A 1 421 ? 93.658  112.525 97.313  1.00 60.07  ? 413 ARG A CZ    1 
ATOM   2157  N  NH1   . ARG A 1 421 ? 94.135  113.614 97.892  1.00 61.23  ? 413 ARG A NH1   1 
ATOM   2158  N  NH2   . ARG A 1 421 ? 92.803  111.756 97.980  1.00 56.70  ? 413 ARG A NH2   1 
ATOM   2159  N  N     . ARG A 1 422 ? 97.323  113.029 89.497  1.00 79.21  ? 414 ARG A N     1 
ATOM   2160  C  CA    . ARG A 1 422 ? 97.874  113.886 88.456  1.00 84.26  ? 414 ARG A CA    1 
ATOM   2161  C  C     . ARG A 1 422 ? 97.125  113.619 87.159  1.00 89.52  ? 414 ARG A C     1 
ATOM   2162  O  O     . ARG A 1 422 ? 96.937  112.460 86.775  1.00 88.01  ? 414 ARG A O     1 
ATOM   2163  C  CB    . ARG A 1 422 ? 99.377  113.647 88.275  1.00 83.36  ? 414 ARG A CB    1 
ATOM   2164  C  CG    . ARG A 1 422 ? 99.764  112.186 88.135  1.00 82.63  ? 414 ARG A CG    1 
ATOM   2165  C  CD    . ARG A 1 422 ? 101.249 112.032 87.858  1.00 88.78  ? 414 ARG A CD    1 
ATOM   2166  N  NE    . ARG A 1 422 ? 101.630 110.634 87.709  1.00 94.81  ? 414 ARG A NE    1 
ATOM   2167  C  CZ    . ARG A 1 422 ? 102.850 110.219 87.397  1.00 97.72  ? 414 ARG A CZ    1 
ATOM   2168  N  NH1   . ARG A 1 422 ? 103.837 111.074 87.187  1.00 101.65 ? 414 ARG A NH1   1 
ATOM   2169  N  NH2   . ARG A 1 422 ? 103.085 108.914 87.293  1.00 98.66  ? 414 ARG A NH2   1 
ATOM   2170  N  N     . GLU A 1 423 ? 96.695  114.687 86.494  1.00 91.71  ? 415 GLU A N     1 
ATOM   2171  C  CA    . GLU A 1 423 ? 95.875  114.544 85.301  1.00 93.79  ? 415 GLU A CA    1 
ATOM   2172  C  C     . GLU A 1 423 ? 96.694  114.003 84.135  1.00 94.80  ? 415 GLU A C     1 
ATOM   2173  O  O     . GLU A 1 423 ? 97.916  114.158 84.074  1.00 92.66  ? 415 GLU A O     1 
ATOM   2174  C  CB    . GLU A 1 423 ? 95.248  115.884 84.919  1.00 97.05  ? 415 GLU A CB    1 
ATOM   2175  C  CG    . GLU A 1 423 ? 94.313  116.452 85.974  1.00 104.60 ? 415 GLU A CG    1 
ATOM   2176  C  CD    . GLU A 1 423 ? 93.574  117.686 85.497  1.00 114.53 ? 415 GLU A CD    1 
ATOM   2177  O  OE1   . GLU A 1 423 ? 93.754  118.072 84.322  1.00 114.61 ? 415 GLU A OE1   1 
ATOM   2178  O  OE2   . GLU A 1 423 ? 92.812  118.270 86.295  1.00 114.64 ? 415 GLU A OE2   1 
ATOM   2179  N  N     . LEU A 1 424 ? 95.999  113.355 83.202  1.00 96.20  ? 416 LEU A N     1 
ATOM   2180  C  CA    . LEU A 1 424 ? 96.634  112.842 81.997  1.00 102.30 ? 416 LEU A CA    1 
ATOM   2181  C  C     . LEU A 1 424 ? 96.945  113.987 81.043  1.00 111.48 ? 416 LEU A C     1 
ATOM   2182  O  O     . LEU A 1 424 ? 96.076  114.812 80.744  1.00 113.25 ? 416 LEU A O     1 
ATOM   2183  C  CB    . LEU A 1 424 ? 95.733  111.814 81.314  1.00 96.63  ? 416 LEU A CB    1 
ATOM   2184  C  CG    . LEU A 1 424 ? 95.686  110.424 81.946  1.00 81.45  ? 416 LEU A CG    1 
ATOM   2185  C  CD1   . LEU A 1 424 ? 94.673  109.547 81.234  1.00 76.00  ? 416 LEU A CD1   1 
ATOM   2186  C  CD2   . LEU A 1 424 ? 97.064  109.789 81.909  1.00 78.06  ? 416 LEU A CD2   1 
ATOM   2187  N  N     . PHE A 1 425 ? 98.185  114.033 80.567  1.00 115.38 ? 417 PHE A N     1 
ATOM   2188  C  CA    . PHE A 1 425 ? 98.596  115.082 79.645  1.00 118.27 ? 417 PHE A CA    1 
ATOM   2189  C  C     . PHE A 1 425 ? 97.917  114.906 78.293  1.00 121.89 ? 417 PHE A C     1 
ATOM   2190  O  O     . PHE A 1 425 ? 97.822  113.795 77.764  1.00 120.13 ? 417 PHE A O     1 
ATOM   2191  C  CB    . PHE A 1 425 ? 100.117 115.077 79.480  1.00 118.81 ? 417 PHE A CB    1 
ATOM   2192  C  CG    . PHE A 1 425 ? 100.686 113.733 79.116  1.00 119.83 ? 417 PHE A CG    1 
ATOM   2193  C  CD1   . PHE A 1 425 ? 101.032 112.822 80.100  1.00 119.97 ? 417 PHE A CD1   1 
ATOM   2194  C  CD2   . PHE A 1 425 ? 100.885 113.385 77.790  1.00 119.38 ? 417 PHE A CD2   1 
ATOM   2195  C  CE1   . PHE A 1 425 ? 101.557 111.588 79.770  1.00 121.63 ? 417 PHE A CE1   1 
ATOM   2196  C  CE2   . PHE A 1 425 ? 101.409 112.151 77.453  1.00 118.19 ? 417 PHE A CE2   1 
ATOM   2197  C  CZ    . PHE A 1 425 ? 101.746 111.252 78.444  1.00 118.51 ? 417 PHE A CZ    1 
ATOM   2198  N  N     . GLY A 1 426 ? 97.431  116.014 77.738  1.00 125.24 ? 418 GLY A N     1 
ATOM   2199  C  CA    . GLY A 1 426 ? 96.811  116.007 76.432  1.00 130.07 ? 418 GLY A CA    1 
ATOM   2200  C  C     . GLY A 1 426 ? 95.374  115.539 76.396  1.00 133.49 ? 418 GLY A C     1 
ATOM   2201  O  O     . GLY A 1 426 ? 94.778  115.514 75.311  1.00 135.04 ? 418 GLY A O     1 
ATOM   2202  N  N     . CYS A 1 427 ? 94.793  115.168 77.537  1.00 130.32 ? 419 CYS A N     1 
ATOM   2203  C  CA    . CYS A 1 427 ? 93.421  114.689 77.587  1.00 129.90 ? 419 CYS A CA    1 
ATOM   2204  C  C     . CYS A 1 427 ? 92.653  115.487 78.633  1.00 130.20 ? 419 CYS A C     1 
ATOM   2205  O  O     . CYS A 1 427 ? 93.126  115.630 79.775  1.00 125.95 ? 419 CYS A O     1 
ATOM   2206  C  CB    . CYS A 1 427 ? 93.368  113.190 77.907  1.00 125.18 ? 419 CYS A CB    1 
ATOM   2207  S  SG    . CYS A 1 427 ? 94.367  112.153 76.810  1.00 125.76 ? 419 CYS A SG    1 
ATOM   2208  N  N     . PRO A 1 428 ? 91.483  116.025 78.293  1.00 133.77 ? 420 PRO A N     1 
ATOM   2209  C  CA    . PRO A 1 428 ? 90.711  116.802 79.273  1.00 132.13 ? 420 PRO A CA    1 
ATOM   2210  C  C     . PRO A 1 428 ? 90.164  115.909 80.378  1.00 129.98 ? 420 PRO A C     1 
ATOM   2211  O  O     . PRO A 1 428 ? 89.712  114.790 80.127  1.00 130.02 ? 420 PRO A O     1 
ATOM   2212  C  CB    . PRO A 1 428 ? 89.586  117.415 78.433  1.00 130.09 ? 420 PRO A CB    1 
ATOM   2213  C  CG    . PRO A 1 428 ? 89.434  116.480 77.278  1.00 131.48 ? 420 PRO A CG    1 
ATOM   2214  C  CD    . PRO A 1 428 ? 90.816  115.968 76.981  1.00 132.90 ? 420 PRO A CD    1 
ATOM   2215  N  N     . SER A 1 429 ? 90.214  116.415 81.608  1.00 126.69 ? 421 SER A N     1 
ATOM   2216  C  CA    . SER A 1 429 ? 89.679  115.690 82.751  1.00 123.43 ? 421 SER A CA    1 
ATOM   2217  C  C     . SER A 1 429 ? 88.256  116.141 83.051  1.00 123.02 ? 421 SER A C     1 
ATOM   2218  O  O     . SER A 1 429 ? 87.962  117.340 83.087  1.00 122.38 ? 421 SER A O     1 
ATOM   2219  C  CB    . SER A 1 429 ? 90.564  115.901 83.979  1.00 119.59 ? 421 SER A CB    1 
ATOM   2220  O  OG    . SER A 1 429 ? 90.619  117.270 84.338  1.00 122.22 ? 421 SER A OG    1 
ATOM   2221  N  N     . GLU A 1 430 ? 87.372  115.171 83.268  1.00 120.53 ? 422 GLU A N     1 
ATOM   2222  C  CA    . GLU A 1 430 ? 85.986  115.477 83.589  1.00 119.09 ? 422 GLU A CA    1 
ATOM   2223  C  C     . GLU A 1 430 ? 85.887  116.165 84.946  1.00 122.10 ? 422 GLU A C     1 
ATOM   2224  O  O     . GLU A 1 430 ? 86.649  115.878 85.873  1.00 121.69 ? 422 GLU A O     1 
ATOM   2225  C  CB    . GLU A 1 430 ? 85.142  114.203 83.584  1.00 117.56 ? 422 GLU A CB    1 
ATOM   2226  C  CG    . GLU A 1 430 ? 85.130  113.468 82.254  1.00 116.10 ? 422 GLU A CG    1 
ATOM   2227  C  CD    . GLU A 1 430 ? 84.297  112.202 82.298  1.00 108.19 ? 422 GLU A CD    1 
ATOM   2228  O  OE1   . GLU A 1 430 ? 83.663  111.942 83.341  1.00 104.55 ? 422 GLU A OE1   1 
ATOM   2229  O  OE2   . GLU A 1 430 ? 84.278  111.466 81.289  1.00 97.50  ? 422 GLU A OE2   1 
ATOM   2230  N  N     . ALA A 1 431 ? 84.932  117.085 85.054  1.00 121.49 ? 423 ALA A N     1 
ATOM   2231  C  CA    . ALA A 1 431 ? 84.758  117.882 86.264  1.00 118.91 ? 423 ALA A CA    1 
ATOM   2232  C  C     . ALA A 1 431 ? 83.966  117.082 87.292  1.00 117.22 ? 423 ALA A C     1 
ATOM   2233  O  O     . ALA A 1 431 ? 82.798  116.751 87.067  1.00 117.83 ? 423 ALA A O     1 
ATOM   2234  C  CB    . ALA A 1 431 ? 84.060  119.198 85.935  1.00 115.44 ? 423 ALA A CB    1 
ATOM   2235  N  N     . ASP A 1 432 ? 84.599  116.774 88.420  1.00 115.44 ? 424 ASP A N     1 
ATOM   2236  C  CA    . ASP A 1 432 ? 83.949  116.084 89.523  1.00 113.59 ? 424 ASP A CA    1 
ATOM   2237  C  C     . ASP A 1 432 ? 83.573  117.083 90.610  1.00 110.91 ? 424 ASP A C     1 
ATOM   2238  O  O     . ASP A 1 432 ? 84.284  118.062 90.852  1.00 110.02 ? 424 ASP A O     1 
ATOM   2239  C  CB    . ASP A 1 432 ? 84.857  114.996 90.100  1.00 112.31 ? 424 ASP A CB    1 
ATOM   2240  C  CG    . ASP A 1 432 ? 84.129  114.081 91.066  1.00 111.46 ? 424 ASP A CG    1 
ATOM   2241  O  OD1   . ASP A 1 432 ? 82.891  114.198 91.184  1.00 108.75 ? 424 ASP A OD1   1 
ATOM   2242  O  OD2   . ASP A 1 432 ? 84.795  113.243 91.710  1.00 112.02 ? 424 ASP A OD2   1 
ATOM   2243  N  N     . VAL A 1 433 ? 82.438  116.824 91.264  1.00 109.30 ? 425 VAL A N     1 
ATOM   2244  C  CA    . VAL A 1 433 ? 81.913  117.763 92.254  1.00 106.38 ? 425 VAL A CA    1 
ATOM   2245  C  C     . VAL A 1 433 ? 82.881  117.907 93.422  1.00 103.94 ? 425 VAL A C     1 
ATOM   2246  O  O     . VAL A 1 433 ? 83.192  119.021 93.860  1.00 103.80 ? 425 VAL A O     1 
ATOM   2247  C  CB    . VAL A 1 433 ? 80.520  117.316 92.730  1.00 105.14 ? 425 VAL A CB    1 
ATOM   2248  C  CG1   . VAL A 1 433 ? 79.973  118.289 93.763  1.00 103.09 ? 425 VAL A CG1   1 
ATOM   2249  C  CG2   . VAL A 1 433 ? 79.572  117.195 91.548  1.00 104.73 ? 425 VAL A CG2   1 
ATOM   2250  N  N     . ASN A 1 434 ? 83.371  116.781 93.944  1.00 103.05 ? 426 ASN A N     1 
ATOM   2251  C  CA    . ASN A 1 434 ? 84.281  116.830 95.085  1.00 103.07 ? 426 ASN A CA    1 
ATOM   2252  C  C     . ASN A 1 434 ? 85.596  117.508 94.719  1.00 103.13 ? 426 ASN A C     1 
ATOM   2253  O  O     . ASN A 1 434 ? 86.114  118.328 95.488  1.00 102.93 ? 426 ASN A O     1 
ATOM   2254  C  CB    . ASN A 1 434 ? 84.530  115.417 95.610  1.00 99.39  ? 426 ASN A CB    1 
ATOM   2255  C  CG    . ASN A 1 434 ? 83.247  114.696 95.962  1.00 98.40  ? 426 ASN A CG    1 
ATOM   2256  O  OD1   . ASN A 1 434 ? 82.350  115.267 96.582  1.00 101.81 ? 426 ASN A OD1   1 
ATOM   2257  N  ND2   . ASN A 1 434 ? 83.147  113.436 95.557  1.00 93.78  ? 426 ASN A ND2   1 
ATOM   2258  N  N     . SER A 1 435 ? 86.151  117.179 93.551  1.00 102.83 ? 427 SER A N     1 
ATOM   2259  C  CA    . SER A 1 435 ? 87.394  117.810 93.120  1.00 99.95  ? 427 SER A CA    1 
ATOM   2260  C  C     . SER A 1 435 ? 87.206  119.305 92.906  1.00 103.20 ? 427 SER A C     1 
ATOM   2261  O  O     . SER A 1 435 ? 88.069  120.106 93.283  1.00 106.94 ? 427 SER A O     1 
ATOM   2262  C  CB    . SER A 1 435 ? 87.905  117.146 91.842  1.00 105.09 ? 427 SER A CB    1 
ATOM   2263  O  OG    . SER A 1 435 ? 87.016  117.375 90.763  1.00 113.67 ? 427 SER A OG    1 
ATOM   2264  N  N     . GLU A 1 436 ? 86.084  119.701 92.298  1.00 101.30 ? 428 GLU A N     1 
ATOM   2265  C  CA    . GLU A 1 436 ? 85.816  121.121 92.099  1.00 103.60 ? 428 GLU A CA    1 
ATOM   2266  C  C     . GLU A 1 436 ? 85.684  121.850 93.429  1.00 102.43 ? 428 GLU A C     1 
ATOM   2267  O  O     . GLU A 1 436 ? 86.213  122.955 93.594  1.00 101.65 ? 428 GLU A O     1 
ATOM   2268  C  CB    . GLU A 1 436 ? 84.551  121.309 91.262  1.00 105.46 ? 428 GLU A CB    1 
ATOM   2269  C  CG    . GLU A 1 436 ? 84.752  121.115 89.770  1.00 107.92 ? 428 GLU A CG    1 
ATOM   2270  C  CD    . GLU A 1 436 ? 83.491  121.398 88.977  1.00 110.79 ? 428 GLU A CD    1 
ATOM   2271  O  OE1   . GLU A 1 436 ? 82.387  121.222 89.532  1.00 110.51 ? 428 GLU A OE1   1 
ATOM   2272  O  OE2   . GLU A 1 436 ? 83.605  121.804 87.801  1.00 111.02 ? 428 GLU A OE2   1 
ATOM   2273  N  N     . ASN A 1 437 ? 84.977  121.248 94.390  1.00 100.81 ? 429 ASN A N     1 
ATOM   2274  C  CA    . ASN A 1 437 ? 84.832  121.876 95.699  1.00 98.32  ? 429 ASN A CA    1 
ATOM   2275  C  C     . ASN A 1 437 ? 86.180  122.021 96.391  1.00 96.53  ? 429 ASN A C     1 
ATOM   2276  O  O     . ASN A 1 437 ? 86.475  123.070 96.976  1.00 95.49  ? 429 ASN A O     1 
ATOM   2277  C  CB    . ASN A 1 437 ? 83.868  121.068 96.567  1.00 97.11  ? 429 ASN A CB    1 
ATOM   2278  C  CG    . ASN A 1 437 ? 82.462  121.039 96.006  1.00 98.83  ? 429 ASN A CG    1 
ATOM   2279  O  OD1   . ASN A 1 437 ? 82.039  121.962 95.311  1.00 100.21 ? 429 ASN A OD1   1 
ATOM   2280  N  ND2   . ASN A 1 437 ? 81.727  119.976 96.307  1.00 98.73  ? 429 ASN A ND2   1 
ATOM   2281  N  N     . LEU A 1 438 ? 87.013  120.979 96.331  1.00 96.48  ? 430 LEU A N     1 
ATOM   2282  C  CA    . LEU A 1 438 ? 88.330  121.055 96.954  1.00 94.58  ? 430 LEU A CA    1 
ATOM   2283  C  C     . LEU A 1 438 ? 89.188  122.130 96.301  1.00 94.03  ? 430 LEU A C     1 
ATOM   2284  O  O     . LEU A 1 438 ? 89.857  122.905 96.994  1.00 96.37  ? 430 LEU A O     1 
ATOM   2285  C  CB    . LEU A 1 438 ? 89.026  119.697 96.884  1.00 91.88  ? 430 LEU A CB    1 
ATOM   2286  C  CG    . LEU A 1 438 ? 90.464  119.653 97.405  1.00 88.95  ? 430 LEU A CG    1 
ATOM   2287  C  CD1   . LEU A 1 438 ? 90.532  120.140 98.843  1.00 84.37  ? 430 LEU A CD1   1 
ATOM   2288  C  CD2   . LEU A 1 438 ? 91.037  118.249 97.287  1.00 83.22  ? 430 LEU A CD2   1 
ATOM   2289  N  N     . GLN A 1 439 ? 89.177  122.197 94.967  1.00 96.08  ? 431 GLN A N     1 
ATOM   2290  C  CA    . GLN A 1 439 ? 89.963  123.212 94.274  1.00 97.36  ? 431 GLN A CA    1 
ATOM   2291  C  C     . GLN A 1 439 ? 89.483  124.614 94.622  1.00 95.26  ? 431 GLN A C     1 
ATOM   2292  O  O     . GLN A 1 439 ? 90.296  125.511 94.868  1.00 97.03  ? 431 GLN A O     1 
ATOM   2293  C  CB    . GLN A 1 439 ? 89.904  122.985 92.764  1.00 105.47 ? 431 GLN A CB    1 
ATOM   2294  C  CG    . GLN A 1 439 ? 90.638  121.742 92.289  1.00 108.59 ? 431 GLN A CG    1 
ATOM   2295  C  CD    . GLN A 1 439 ? 90.509  121.526 90.793  1.00 113.19 ? 431 GLN A CD    1 
ATOM   2296  O  OE1   . GLN A 1 439 ? 89.885  122.322 90.090  1.00 115.90 ? 431 GLN A OE1   1 
ATOM   2297  N  NE2   . GLN A 1 439 ? 91.100  120.444 90.298  1.00 109.01 ? 431 GLN A NE2   1 
ATOM   2298  N  N     . LYS A 1 440 ? 88.164  124.818 94.661  1.00 95.05  ? 432 LYS A N     1 
ATOM   2299  C  CA    . LYS A 1 440 ? 87.625  126.132 94.998  1.00 96.71  ? 432 LYS A CA    1 
ATOM   2300  C  C     . LYS A 1 440 ? 88.004  126.533 96.418  1.00 97.00  ? 432 LYS A C     1 
ATOM   2301  O  O     . LYS A 1 440 ? 88.443  127.664 96.661  1.00 98.12  ? 432 LYS A O     1 
ATOM   2302  C  CB    . LYS A 1 440 ? 86.106  126.130 94.825  1.00 97.19  ? 432 LYS A CB    1 
ATOM   2303  C  CG    . LYS A 1 440 ? 85.429  127.423 95.241  1.00 96.32  ? 432 LYS A CG    1 
ATOM   2304  C  CD    . LYS A 1 440 ? 83.919  127.322 95.096  1.00 96.33  ? 432 LYS A CD    1 
ATOM   2305  C  CE    . LYS A 1 440 ? 83.235  128.613 95.512  1.00 95.12  ? 432 LYS A CE    1 
ATOM   2306  N  NZ    . LYS A 1 440 ? 81.754  128.520 95.391  1.00 88.84  ? 432 LYS A NZ    1 
ATOM   2307  N  N     . GLN A 1 441 ? 87.854  125.608 97.370  1.00 95.53  ? 433 GLN A N     1 
ATOM   2308  C  CA    . GLN A 1 441 ? 88.172  125.922 98.759  1.00 92.24  ? 433 GLN A CA    1 
ATOM   2309  C  C     . GLN A 1 441 ? 89.657  126.209 98.939  1.00 92.62  ? 433 GLN A C     1 
ATOM   2310  O  O     . GLN A 1 441 ? 90.030  127.131 99.672  1.00 93.50  ? 433 GLN A O     1 
ATOM   2311  C  CB    . GLN A 1 441 ? 87.721  124.782 99.668  1.00 89.46  ? 433 GLN A CB    1 
ATOM   2312  C  CG    . GLN A 1 441 ? 86.212  124.678 99.804  1.00 89.50  ? 433 GLN A CG    1 
ATOM   2313  C  CD    . GLN A 1 441 ? 85.779  123.482 100.624 1.00 93.30  ? 433 GLN A CD    1 
ATOM   2314  O  OE1   . GLN A 1 441 ? 86.487  122.478 100.701 1.00 92.64  ? 433 GLN A OE1   1 
ATOM   2315  N  NE2   . GLN A 1 441 ? 84.611  123.584 101.246 1.00 94.59  ? 433 GLN A NE2   1 
ATOM   2316  N  N     . LEU A 1 442 ? 90.522  125.436 98.276  1.00 93.35  ? 434 LEU A N     1 
ATOM   2317  C  CA    . LEU A 1 442 ? 91.953  125.696 98.378  1.00 92.67  ? 434 LEU A CA    1 
ATOM   2318  C  C     . LEU A 1 442 ? 92.336  127.006 97.703  1.00 95.14  ? 434 LEU A C     1 
ATOM   2319  O  O     . LEU A 1 442 ? 93.264  127.684 98.156  1.00 99.61  ? 434 LEU A O     1 
ATOM   2320  C  CB    . LEU A 1 442 ? 92.746  124.534 97.781  1.00 89.49  ? 434 LEU A CB    1 
ATOM   2321  C  CG    . LEU A 1 442 ? 92.720  123.235 98.587  1.00 87.16  ? 434 LEU A CG    1 
ATOM   2322  C  CD1   . LEU A 1 442 ? 93.581  122.173 97.926  1.00 86.79  ? 434 LEU A CD1   1 
ATOM   2323  C  CD2   . LEU A 1 442 ? 93.175  123.484 100.014 1.00 88.53  ? 434 LEU A CD2   1 
ATOM   2324  N  N     . SER A 1 443 ? 91.643  127.377 96.624  1.00 93.46  ? 435 SER A N     1 
ATOM   2325  C  CA    . SER A 1 443 ? 91.915  128.656 95.979  1.00 93.98  ? 435 SER A CA    1 
ATOM   2326  C  C     . SER A 1 443 ? 91.473  129.820 96.856  1.00 100.54 ? 435 SER A C     1 
ATOM   2327  O  O     . SER A 1 443 ? 92.109  130.881 96.855  1.00 104.56 ? 435 SER A O     1 
ATOM   2328  C  CB    . SER A 1 443 ? 91.223  128.715 94.619  1.00 96.31  ? 435 SER A CB    1 
ATOM   2329  O  OG    . SER A 1 443 ? 89.821  128.566 94.758  1.00 99.63  ? 435 SER A OG    1 
ATOM   2330  N  N     . GLU A 1 444 ? 90.382  129.645 97.607  1.00 100.63 ? 436 GLU A N     1 
ATOM   2331  C  CA    . GLU A 1 444 ? 89.933  130.703 98.507  1.00 98.11  ? 436 GLU A CA    1 
ATOM   2332  C  C     . GLU A 1 444 ? 90.943  130.969 99.616  1.00 96.64  ? 436 GLU A C     1 
ATOM   2333  O  O     . GLU A 1 444 ? 91.040  132.099 100.108 1.00 96.63  ? 436 GLU A O     1 
ATOM   2334  C  CB    . GLU A 1 444 ? 88.575  130.345 99.110  1.00 96.33  ? 436 GLU A CB    1 
ATOM   2335  C  CG    . GLU A 1 444 ? 87.436  130.300 98.109  1.00 98.94  ? 436 GLU A CG    1 
ATOM   2336  C  CD    . GLU A 1 444 ? 86.130  129.863 98.741  1.00 101.19 ? 436 GLU A CD    1 
ATOM   2337  O  OE1   . GLU A 1 444 ? 86.074  129.773 99.985  1.00 102.16 ? 436 GLU A OE1   1 
ATOM   2338  O  OE2   . GLU A 1 444 ? 85.162  129.608 97.995  1.00 100.21 ? 436 GLU A OE2   1 
ATOM   2339  N  N     . LEU A 1 445 ? 91.696  129.950 100.024 1.00 97.56  ? 437 LEU A N     1 
ATOM   2340  C  CA    . LEU A 1 445 ? 92.651  130.106 101.113 1.00 100.88 ? 437 LEU A CA    1 
ATOM   2341  C  C     . LEU A 1 445 ? 93.821  130.981 100.682 1.00 104.15 ? 437 LEU A C     1 
ATOM   2342  O  O     . LEU A 1 445 ? 94.330  130.853 99.564  1.00 106.13 ? 437 LEU A O     1 
ATOM   2343  C  CB    . LEU A 1 445 ? 93.156  128.739 101.572 1.00 100.05 ? 437 LEU A CB    1 
ATOM   2344  C  CG    . LEU A 1 445 ? 92.100  127.762 102.087 1.00 94.79  ? 437 LEU A CG    1 
ATOM   2345  C  CD1   . LEU A 1 445 ? 92.739  126.434 102.455 1.00 91.36  ? 437 LEU A CD1   1 
ATOM   2346  C  CD2   . LEU A 1 445 ? 91.353  128.349 103.274 1.00 91.41  ? 437 LEU A CD2   1 
ATOM   2347  N  N     . ASP A 1 446 ? 94.250  131.869 101.575 1.00 106.60 ? 438 ASP A N     1 
ATOM   2348  C  CA    . ASP A 1 446 ? 95.375  132.753 101.301 1.00 109.99 ? 438 ASP A CA    1 
ATOM   2349  C  C     . ASP A 1 446 ? 96.676  132.050 101.670 1.00 113.10 ? 438 ASP A C     1 
ATOM   2350  O  O     . ASP A 1 446 ? 96.847  131.605 102.810 1.00 116.95 ? 438 ASP A O     1 
ATOM   2351  C  CB    . ASP A 1 446 ? 95.227  134.057 102.081 1.00 114.78 ? 438 ASP A CB    1 
ATOM   2352  C  CG    . ASP A 1 446 ? 96.305  135.069 101.741 1.00 119.06 ? 438 ASP A CG    1 
ATOM   2353  O  OD1   . ASP A 1 446 ? 97.050  134.848 100.762 1.00 119.86 ? 438 ASP A OD1   1 
ATOM   2354  O  OD2   . ASP A 1 446 ? 96.408  136.089 102.454 1.00 118.67 ? 438 ASP A OD2   1 
ATOM   2355  N  N     . GLU A 1 447 ? 97.593  131.950 100.706 1.00 115.26 ? 439 GLU A N     1 
ATOM   2356  C  CA    . GLU A 1 447 ? 98.888  131.336 100.966 1.00 117.99 ? 439 GLU A CA    1 
ATOM   2357  C  C     . GLU A 1 447 ? 99.821  132.243 101.755 1.00 120.24 ? 439 GLU A C     1 
ATOM   2358  O  O     . GLU A 1 447 ? 100.787 131.749 102.348 1.00 117.96 ? 439 GLU A O     1 
ATOM   2359  C  CB    . GLU A 1 447 ? 99.556  130.933 99.650  1.00 118.18 ? 439 GLU A CB    1 
ATOM   2360  C  CG    . GLU A 1 447 ? 98.757  129.936 98.829  1.00 118.56 ? 439 GLU A CG    1 
ATOM   2361  C  CD    . GLU A 1 447 ? 99.494  129.485 97.584  1.00 126.14 ? 439 GLU A CD    1 
ATOM   2362  O  OE1   . GLU A 1 447 ? 100.694 129.806 97.453  1.00 127.01 ? 439 GLU A OE1   1 
ATOM   2363  O  OE2   . GLU A 1 447 ? 98.873  128.811 96.735  1.00 130.59 ? 439 GLU A OE2   1 
ATOM   2364  N  N     . ASP A 1 448 ? 99.562  133.553 101.773 1.00 123.32 ? 440 ASP A N     1 
ATOM   2365  C  CA    . ASP A 1 448 ? 100.398 134.464 102.546 1.00 124.19 ? 440 ASP A CA    1 
ATOM   2366  C  C     . ASP A 1 448 ? 100.135 134.361 104.042 1.00 124.54 ? 440 ASP A C     1 
ATOM   2367  O  O     . ASP A 1 448 ? 100.986 134.771 104.837 1.00 124.24 ? 440 ASP A O     1 
ATOM   2368  C  CB    . ASP A 1 448 ? 100.183 135.905 102.081 1.00 125.55 ? 440 ASP A CB    1 
ATOM   2369  C  CG    . ASP A 1 448 ? 100.631 136.128 100.651 1.00 131.03 ? 440 ASP A CG    1 
ATOM   2370  O  OD1   . ASP A 1 448 ? 101.554 135.419 100.198 1.00 131.70 ? 440 ASP A OD1   1 
ATOM   2371  O  OD2   . ASP A 1 448 ? 100.061 137.014 99.980  1.00 132.43 ? 440 ASP A OD2   1 
ATOM   2372  N  N     . ASP A 1 449 ? 98.981  133.830 104.438 1.00 123.62 ? 441 ASP A N     1 
ATOM   2373  C  CA    . ASP A 1 449 ? 98.678  133.664 105.852 1.00 119.75 ? 441 ASP A CA    1 
ATOM   2374  C  C     . ASP A 1 449 ? 99.602  132.620 106.467 1.00 118.68 ? 441 ASP A C     1 
ATOM   2375  O  O     . ASP A 1 449 ? 99.881  131.580 105.864 1.00 119.97 ? 441 ASP A O     1 
ATOM   2376  C  CB    . ASP A 1 449 ? 97.217  133.254 106.035 1.00 116.66 ? 441 ASP A CB    1 
ATOM   2377  C  CG    . ASP A 1 449 ? 96.711  133.504 107.443 1.00 116.51 ? 441 ASP A CG    1 
ATOM   2378  O  OD1   . ASP A 1 449 ? 97.534  133.547 108.382 1.00 118.78 ? 441 ASP A OD1   1 
ATOM   2379  O  OD2   . ASP A 1 449 ? 95.483  133.657 107.612 1.00 113.83 ? 441 ASP A OD2   1 
ATOM   2380  N  N     . LEU A 1 450 ? 100.076 132.904 107.682 1.00 116.99 ? 442 LEU A N     1 
ATOM   2381  C  CA    . LEU A 1 450 ? 100.998 131.996 108.353 1.00 115.05 ? 442 LEU A CA    1 
ATOM   2382  C  C     . LEU A 1 450 ? 100.343 130.670 108.720 1.00 111.98 ? 442 LEU A C     1 
ATOM   2383  O  O     . LEU A 1 450 ? 101.047 129.667 108.876 1.00 108.14 ? 442 LEU A O     1 
ATOM   2384  C  CB    . LEU A 1 450 ? 101.571 132.665 109.605 1.00 114.80 ? 442 LEU A CB    1 
ATOM   2385  C  CG    . LEU A 1 450 ? 102.804 132.013 110.235 1.00 114.33 ? 442 LEU A CG    1 
ATOM   2386  C  CD1   . LEU A 1 450 ? 103.955 131.973 109.241 1.00 108.71 ? 442 LEU A CD1   1 
ATOM   2387  C  CD2   . LEU A 1 450 ? 103.211 132.745 111.504 1.00 112.39 ? 442 LEU A CD2   1 
ATOM   2388  N  N     . CYS A 1 451 ? 99.016  130.640 108.850 1.00 112.48 ? 443 CYS A N     1 
ATOM   2389  C  CA    . CYS A 1 451 ? 98.279  129.423 109.166 1.00 109.73 ? 443 CYS A CA    1 
ATOM   2390  C  C     . CYS A 1 451 ? 97.711  128.754 107.919 1.00 105.56 ? 443 CYS A C     1 
ATOM   2391  O  O     . CYS A 1 451 ? 96.642  128.137 107.976 1.00 101.29 ? 443 CYS A O     1 
ATOM   2392  C  CB    . CYS A 1 451 ? 97.161  129.725 110.163 1.00 109.98 ? 443 CYS A CB    1 
ATOM   2393  S  SG    . CYS A 1 451 ? 95.944  130.929 109.583 1.00 114.68 ? 443 CYS A SG    1 
ATOM   2394  N  N     . TYR A 1 452 ? 98.410  128.871 106.787 1.00 107.40 ? 444 TYR A N     1 
ATOM   2395  C  CA    . TYR A 1 452 ? 97.919  128.286 105.544 1.00 104.18 ? 444 TYR A CA    1 
ATOM   2396  C  C     . TYR A 1 452 ? 97.844  126.767 105.635 1.00 99.59  ? 444 TYR A C     1 
ATOM   2397  O  O     . TYR A 1 452 ? 96.908  126.153 105.112 1.00 101.26 ? 444 TYR A O     1 
ATOM   2398  C  CB    . TYR A 1 452 ? 98.813  128.711 104.378 1.00 106.31 ? 444 TYR A CB    1 
ATOM   2399  C  CG    . TYR A 1 452 ? 98.541  127.968 103.089 1.00 110.33 ? 444 TYR A CG    1 
ATOM   2400  C  CD1   . TYR A 1 452 ? 97.431  128.269 102.312 1.00 110.18 ? 444 TYR A CD1   1 
ATOM   2401  C  CD2   . TYR A 1 452 ? 99.398  126.969 102.646 1.00 107.49 ? 444 TYR A CD2   1 
ATOM   2402  C  CE1   . TYR A 1 452 ? 97.179  127.593 101.133 1.00 108.17 ? 444 TYR A CE1   1 
ATOM   2403  C  CE2   . TYR A 1 452 ? 99.155  126.289 101.469 1.00 104.39 ? 444 TYR A CE2   1 
ATOM   2404  C  CZ    . TYR A 1 452 ? 98.045  126.605 100.717 1.00 106.60 ? 444 TYR A CZ    1 
ATOM   2405  O  OH    . TYR A 1 452 ? 97.800  125.929 99.544  1.00 106.88 ? 444 TYR A OH    1 
ATOM   2406  N  N     . GLU A 1 453 ? 98.827  126.145 106.289 1.00 96.76  ? 445 GLU A N     1 
ATOM   2407  C  CA    . GLU A 1 453 ? 98.878  124.688 106.343 1.00 97.24  ? 445 GLU A CA    1 
ATOM   2408  C  C     . GLU A 1 453 ? 97.669  124.111 107.072 1.00 95.59  ? 445 GLU A C     1 
ATOM   2409  O  O     . GLU A 1 453 ? 97.085  123.117 106.627 1.00 96.01  ? 445 GLU A O     1 
ATOM   2410  C  CB    . GLU A 1 453 ? 100.176 124.241 107.012 1.00 101.04 ? 445 GLU A CB    1 
ATOM   2411  C  CG    . GLU A 1 453 ? 101.431 124.773 106.341 1.00 103.77 ? 445 GLU A CG    1 
ATOM   2412  C  CD    . GLU A 1 453 ? 102.693 124.432 107.107 1.00 110.99 ? 445 GLU A CD    1 
ATOM   2413  O  OE1   . GLU A 1 453 ? 102.587 123.802 108.181 1.00 109.89 ? 445 GLU A OE1   1 
ATOM   2414  O  OE2   . GLU A 1 453 ? 103.792 124.795 106.638 1.00 112.96 ? 445 GLU A OE2   1 
ATOM   2415  N  N     . PHE A 1 454 ? 97.276  124.723 108.191 1.00 94.86  ? 446 PHE A N     1 
ATOM   2416  C  CA    . PHE A 1 454 ? 96.145  124.209 108.959 1.00 92.66  ? 446 PHE A CA    1 
ATOM   2417  C  C     . PHE A 1 454 ? 94.838  124.348 108.189 1.00 91.72  ? 446 PHE A C     1 
ATOM   2418  O  O     . PHE A 1 454 ? 94.027  123.413 108.152 1.00 91.67  ? 446 PHE A O     1 
ATOM   2419  C  CB    . PHE A 1 454 ? 96.057  124.931 110.301 1.00 92.77  ? 446 PHE A CB    1 
ATOM   2420  C  CG    . PHE A 1 454 ? 97.265  124.738 111.165 1.00 95.48  ? 446 PHE A CG    1 
ATOM   2421  C  CD1   . PHE A 1 454 ? 98.358  125.579 111.049 1.00 98.79  ? 446 PHE A CD1   1 
ATOM   2422  C  CD2   . PHE A 1 454 ? 97.311  123.711 112.088 1.00 94.97  ? 446 PHE A CD2   1 
ATOM   2423  C  CE1   . PHE A 1 454 ? 99.473  125.399 111.839 1.00 98.94  ? 446 PHE A CE1   1 
ATOM   2424  C  CE2   . PHE A 1 454 ? 98.422  123.528 112.881 1.00 94.84  ? 446 PHE A CE2   1 
ATOM   2425  C  CZ    . PHE A 1 454 ? 99.504  124.375 112.758 1.00 97.01  ? 446 PHE A CZ    1 
ATOM   2426  N  N     . ARG A 1 455 ? 94.613  125.506 107.566 1.00 87.95  ? 447 ARG A N     1 
ATOM   2427  C  CA    . ARG A 1 455 ? 93.396  125.694 106.787 1.00 85.15  ? 447 ARG A CA    1 
ATOM   2428  C  C     . ARG A 1 455 ? 93.362  124.751 105.591 1.00 85.31  ? 447 ARG A C     1 
ATOM   2429  O  O     . ARG A 1 455 ? 92.300  124.231 105.232 1.00 82.97  ? 447 ARG A O     1 
ATOM   2430  C  CB    . ARG A 1 455 ? 93.283  127.149 106.340 1.00 91.61  ? 447 ARG A CB    1 
ATOM   2431  C  CG    . ARG A 1 455 ? 93.379  128.141 107.486 1.00 92.66  ? 447 ARG A CG    1 
ATOM   2432  C  CD    . ARG A 1 455 ? 93.200  129.568 107.005 1.00 96.50  ? 447 ARG A CD    1 
ATOM   2433  N  NE    . ARG A 1 455 ? 93.461  130.535 108.064 1.00 100.18 ? 447 ARG A NE    1 
ATOM   2434  C  CZ    . ARG A 1 455 ? 92.561  130.936 108.951 1.00 100.38 ? 447 ARG A CZ    1 
ATOM   2435  N  NH1   . ARG A 1 455 ? 91.325  130.465 108.943 1.00 98.72  ? 447 ARG A NH1   1 
ATOM   2436  N  NH2   . ARG A 1 455 ? 92.911  131.830 109.872 1.00 103.17 ? 447 ARG A NH2   1 
ATOM   2437  N  N     . ARG A 1 456 ? 94.517  124.519 104.963 1.00 88.35  ? 448 ARG A N     1 
ATOM   2438  C  CA    . ARG A 1 456 ? 94.586  123.556 103.870 1.00 86.25  ? 448 ARG A CA    1 
ATOM   2439  C  C     . ARG A 1 456 ? 94.249  122.152 104.352 1.00 83.51  ? 448 ARG A C     1 
ATOM   2440  O  O     . ARG A 1 456 ? 93.511  121.418 103.684 1.00 84.93  ? 448 ARG A O     1 
ATOM   2441  C  CB    . ARG A 1 456 ? 95.977  123.585 103.238 1.00 91.11  ? 448 ARG A CB    1 
ATOM   2442  C  CG    . ARG A 1 456 ? 96.171  122.589 102.110 1.00 93.45  ? 448 ARG A CG    1 
ATOM   2443  C  CD    . ARG A 1 456 ? 97.632  122.500 101.706 1.00 99.86  ? 448 ARG A CD    1 
ATOM   2444  N  NE    . ARG A 1 456 ? 98.474  122.097 102.826 1.00 109.93 ? 448 ARG A NE    1 
ATOM   2445  C  CZ    . ARG A 1 456 ? 99.783  121.898 102.748 1.00 111.77 ? 448 ARG A CZ    1 
ATOM   2446  N  NH1   . ARG A 1 456 ? 100.439 122.051 101.610 1.00 116.64 ? 448 ARG A NH1   1 
ATOM   2447  N  NH2   . ARG A 1 456 ? 100.450 121.535 103.841 1.00 98.94  ? 448 ARG A NH2   1 
ATOM   2448  N  N     . GLU A 1 457 ? 94.778  121.762 105.513 1.00 83.62  ? 449 GLU A N     1 
ATOM   2449  C  CA    . GLU A 1 457 ? 94.499  120.435 106.050 1.00 82.01  ? 449 GLU A CA    1 
ATOM   2450  C  C     . GLU A 1 457 ? 93.041  120.294 106.469 1.00 79.31  ? 449 GLU A C     1 
ATOM   2451  O  O     . GLU A 1 457 ? 92.513  119.176 106.500 1.00 78.41  ? 449 GLU A O     1 
ATOM   2452  C  CB    . GLU A 1 457 ? 95.424  120.147 107.233 1.00 83.52  ? 449 GLU A CB    1 
ATOM   2453  C  CG    . GLU A 1 457 ? 95.429  118.699 107.696 1.00 82.65  ? 449 GLU A CG    1 
ATOM   2454  C  CD    . GLU A 1 457 ? 96.203  117.788 106.762 1.00 81.51  ? 449 GLU A CD    1 
ATOM   2455  O  OE1   . GLU A 1 457 ? 96.956  118.306 105.911 1.00 81.54  ? 449 GLU A OE1   1 
ATOM   2456  O  OE2   . GLU A 1 457 ? 96.059  116.553 106.881 1.00 77.70  ? 449 GLU A OE2   1 
ATOM   2457  N  N     . ARG A 1 458 ? 92.382  121.406 106.802 1.00 75.11  ? 450 ARG A N     1 
ATOM   2458  C  CA    . ARG A 1 458 ? 90.982  121.341 107.213 1.00 70.98  ? 450 ARG A CA    1 
ATOM   2459  C  C     . ARG A 1 458 ? 90.100  120.777 106.104 1.00 73.15  ? 450 ARG A C     1 
ATOM   2460  O  O     . ARG A 1 458 ? 89.277  119.886 106.342 1.00 70.96  ? 450 ARG A O     1 
ATOM   2461  C  CB    . ARG A 1 458 ? 90.490  122.726 107.627 1.00 68.88  ? 450 ARG A CB    1 
ATOM   2462  C  CG    . ARG A 1 458 ? 88.982  122.801 107.800 1.00 69.66  ? 450 ARG A CG    1 
ATOM   2463  C  CD    . ARG A 1 458 ? 88.519  124.217 108.087 1.00 73.52  ? 450 ARG A CD    1 
ATOM   2464  N  NE    . ARG A 1 458 ? 87.068  124.294 108.202 1.00 75.59  ? 450 ARG A NE    1 
ATOM   2465  C  CZ    . ARG A 1 458 ? 86.397  125.404 108.473 1.00 79.61  ? 450 ARG A CZ    1 
ATOM   2466  N  NH1   . ARG A 1 458 ? 87.016  126.557 108.664 1.00 81.32  ? 450 ARG A NH1   1 
ATOM   2467  N  NH2   . ARG A 1 458 ? 85.071  125.356 108.556 1.00 81.69  ? 450 ARG A NH2   1 
ATOM   2468  N  N     . PHE A 1 459 ? 90.257  121.283 104.884 1.00 76.08  ? 451 PHE A N     1 
ATOM   2469  C  CA    . PHE A 1 459 ? 89.432  120.859 103.761 1.00 72.41  ? 451 PHE A CA    1 
ATOM   2470  C  C     . PHE A 1 459 ? 90.053  119.727 102.957 1.00 71.21  ? 451 PHE A C     1 
ATOM   2471  O  O     . PHE A 1 459 ? 89.435  119.262 101.994 1.00 71.51  ? 451 PHE A O     1 
ATOM   2472  C  CB    . PHE A 1 459 ? 89.149  122.045 102.834 1.00 74.63  ? 451 PHE A CB    1 
ATOM   2473  C  CG    . PHE A 1 459 ? 88.428  123.176 103.503 1.00 77.23  ? 451 PHE A CG    1 
ATOM   2474  C  CD1   . PHE A 1 459 ? 87.082  123.073 103.806 1.00 80.56  ? 451 PHE A CD1   1 
ATOM   2475  C  CD2   . PHE A 1 459 ? 89.094  124.345 103.824 1.00 79.84  ? 451 PHE A CD2   1 
ATOM   2476  C  CE1   . PHE A 1 459 ? 86.415  124.111 104.421 1.00 84.82  ? 451 PHE A CE1   1 
ATOM   2477  C  CE2   . PHE A 1 459 ? 88.432  125.388 104.439 1.00 83.55  ? 451 PHE A CE2   1 
ATOM   2478  C  CZ    . PHE A 1 459 ? 87.090  125.271 104.738 1.00 84.54  ? 451 PHE A CZ    1 
ATOM   2479  N  N     . THR A 1 460 ? 91.252  119.279 103.322 1.00 70.96  ? 452 THR A N     1 
ATOM   2480  C  CA    . THR A 1 460 ? 91.908  118.204 102.591 1.00 66.61  ? 452 THR A CA    1 
ATOM   2481  C  C     . THR A 1 460 ? 91.075  116.932 102.652 1.00 65.20  ? 452 THR A C     1 
ATOM   2482  O  O     . THR A 1 460 ? 90.601  116.535 103.720 1.00 68.81  ? 452 THR A O     1 
ATOM   2483  C  CB    . THR A 1 460 ? 93.303  117.953 103.165 1.00 70.63  ? 452 THR A CB    1 
ATOM   2484  O  OG1   . THR A 1 460 ? 94.140  119.087 102.906 1.00 76.17  ? 452 THR A OG1   1 
ATOM   2485  C  CG2   . THR A 1 460 ? 93.929  116.716 102.543 1.00 69.38  ? 452 THR A CG2   1 
ATOM   2486  N  N     . VAL A 1 461 ? 90.891  116.297 101.500 1.00 64.47  ? 453 VAL A N     1 
ATOM   2487  C  CA    . VAL A 1 461 ? 90.148  115.048 101.397 1.00 62.37  ? 453 VAL A CA    1 
ATOM   2488  C  C     . VAL A 1 461 ? 91.151  113.905 101.410 1.00 61.52  ? 453 VAL A C     1 
ATOM   2489  O  O     . VAL A 1 461 ? 92.039  113.836 100.552 1.00 60.39  ? 453 VAL A O     1 
ATOM   2490  C  CB    . VAL A 1 461 ? 89.279  115.013 100.132 1.00 62.58  ? 453 VAL A CB    1 
ATOM   2491  C  CG1   . VAL A 1 461 ? 88.627  113.652 99.978  1.00 57.54  ? 453 VAL A CG1   1 
ATOM   2492  C  CG2   . VAL A 1 461 ? 88.226  116.105 100.193 1.00 68.79  ? 453 VAL A CG2   1 
ATOM   2493  N  N     . HIS A 1 462 ? 91.009  113.009 102.381 1.00 61.37  ? 454 HIS A N     1 
ATOM   2494  C  CA    . HIS A 1 462 ? 91.934  111.902 102.571 1.00 56.27  ? 454 HIS A CA    1 
ATOM   2495  C  C     . HIS A 1 462 ? 91.314  110.618 102.040 1.00 49.74  ? 454 HIS A C     1 
ATOM   2496  O  O     . HIS A 1 462 ? 90.147  110.326 102.319 1.00 51.95  ? 454 HIS A O     1 
ATOM   2497  C  CB    . HIS A 1 462 ? 92.291  111.740 104.049 1.00 55.10  ? 454 HIS A CB    1 
ATOM   2498  C  CG    . HIS A 1 462 ? 93.083  112.879 104.610 1.00 60.41  ? 454 HIS A CG    1 
ATOM   2499  N  ND1   . HIS A 1 462 ? 94.426  112.777 104.901 1.00 62.94  ? 454 HIS A ND1   1 
ATOM   2500  C  CD2   . HIS A 1 462 ? 92.723  114.142 104.934 1.00 61.42  ? 454 HIS A CD2   1 
ATOM   2501  C  CE1   . HIS A 1 462 ? 94.859  113.929 105.380 1.00 66.14  ? 454 HIS A CE1   1 
ATOM   2502  N  NE2   . HIS A 1 462 ? 93.845  114.774 105.411 1.00 66.43  ? 454 HIS A NE2   1 
ATOM   2503  N  N     . ARG A 1 463 ? 92.096  109.862 101.276 1.00 44.70  ? 455 ARG A N     1 
ATOM   2504  C  CA    . ARG A 1 463 ? 91.632  108.588 100.746 1.00 40.67  ? 455 ARG A CA    1 
ATOM   2505  C  C     . ARG A 1 463 ? 91.292  107.639 101.887 1.00 41.13  ? 455 ARG A C     1 
ATOM   2506  O  O     . ARG A 1 463 ? 92.162  107.273 102.682 1.00 43.29  ? 455 ARG A O     1 
ATOM   2507  C  CB    . ARG A 1 463 ? 92.702  107.986 99.839  1.00 40.74  ? 455 ARG A CB    1 
ATOM   2508  C  CG    . ARG A 1 463 ? 92.407  106.578 99.361  1.00 39.69  ? 455 ARG A CG    1 
ATOM   2509  C  CD    . ARG A 1 463 ? 93.325  106.203 98.213  1.00 43.46  ? 455 ARG A CD    1 
ATOM   2510  N  NE    . ARG A 1 463 ? 94.716  106.534 98.496  1.00 49.76  ? 455 ARG A NE    1 
ATOM   2511  C  CZ    . ARG A 1 463 ? 95.640  105.653 98.854  1.00 49.91  ? 455 ARG A CZ    1 
ATOM   2512  N  NH1   . ARG A 1 463 ? 95.359  104.366 98.970  1.00 44.72  ? 455 ARG A NH1   1 
ATOM   2513  N  NH2   . ARG A 1 463 ? 96.878  106.073 99.096  1.00 51.49  ? 455 ARG A NH2   1 
ATOM   2514  N  N     . THR A 1 464 ? 90.025  107.245 101.968 1.00 38.61  ? 456 THR A N     1 
ATOM   2515  C  CA    . THR A 1 464 ? 89.515  106.445 103.072 1.00 35.73  ? 456 THR A CA    1 
ATOM   2516  C  C     . THR A 1 464 ? 89.127  105.063 102.571 1.00 34.86  ? 456 THR A C     1 
ATOM   2517  O  O     . THR A 1 464 ? 88.414  104.937 101.571 1.00 33.47  ? 456 THR A O     1 
ATOM   2518  C  CB    . THR A 1 464 ? 88.311  107.124 103.727 1.00 36.25  ? 456 THR A CB    1 
ATOM   2519  O  OG1   . THR A 1 464 ? 88.672  108.449 104.133 1.00 41.22  ? 456 THR A OG1   1 
ATOM   2520  C  CG2   . THR A 1 464 ? 87.855  106.337 104.942 1.00 37.57  ? 456 THR A CG2   1 
ATOM   2521  N  N     . HIS A 1 465 ? 89.590  104.033 103.272 1.00 36.93  ? 457 HIS A N     1 
ATOM   2522  C  CA    . HIS A 1 465 ? 89.303  102.641 102.936 1.00 35.37  ? 457 HIS A CA    1 
ATOM   2523  C  C     . HIS A 1 465 ? 88.516  102.039 104.096 1.00 31.20  ? 457 HIS A C     1 
ATOM   2524  O  O     . HIS A 1 465 ? 89.102  101.567 105.074 1.00 31.40  ? 457 HIS A O     1 
ATOM   2525  C  CB    . HIS A 1 465 ? 90.593  101.873 102.664 1.00 34.72  ? 457 HIS A CB    1 
ATOM   2526  C  CG    . HIS A 1 465 ? 90.382  100.523 102.054 1.00 35.58  ? 457 HIS A CG    1 
ATOM   2527  N  ND1   . HIS A 1 465 ? 91.237  99.993  101.113 1.00 34.32  ? 457 HIS A ND1   1 
ATOM   2528  C  CD2   . HIS A 1 465 ? 89.421  99.591  102.256 1.00 35.81  ? 457 HIS A CD2   1 
ATOM   2529  C  CE1   . HIS A 1 465 ? 90.808  98.796  100.757 1.00 36.02  ? 457 HIS A CE1   1 
ATOM   2530  N  NE2   . HIS A 1 465 ? 89.708  98.528  101.436 1.00 35.12  ? 457 HIS A NE2   1 
ATOM   2531  N  N     . LEU A 1 466 ? 87.192  102.058 103.985 1.00 29.63  ? 458 LEU A N     1 
ATOM   2532  C  CA    . LEU A 1 466 ? 86.342  101.538 105.046 1.00 30.53  ? 458 LEU A CA    1 
ATOM   2533  C  C     . LEU A 1 466 ? 86.474  100.026 105.152 1.00 34.20  ? 458 LEU A C     1 
ATOM   2534  O  O     . LEU A 1 466 ? 86.567  99.324  104.142 1.00 36.34  ? 458 LEU A O     1 
ATOM   2535  C  CB    . LEU A 1 466 ? 84.885  101.912 104.786 1.00 31.90  ? 458 LEU A CB    1 
ATOM   2536  C  CG    . LEU A 1 466 ? 84.604  103.391 104.535 1.00 35.75  ? 458 LEU A CG    1 
ATOM   2537  C  CD1   . LEU A 1 466 ? 83.140  103.593 104.198 1.00 41.07  ? 458 LEU A CD1   1 
ATOM   2538  C  CD2   . LEU A 1 466 ? 85.003  104.217 105.741 1.00 30.48  ? 458 LEU A CD2   1 
ATOM   2539  N  N     . TYR A 1 467 ? 86.471  99.528  106.386 1.00 32.71  ? 459 TYR A N     1 
ATOM   2540  C  CA    . TYR A 1 467 ? 86.514  98.096  106.674 1.00 32.65  ? 459 TYR A CA    1 
ATOM   2541  C  C     . TYR A 1 467 ? 87.698  97.429  105.974 1.00 33.26  ? 459 TYR A C     1 
ATOM   2542  O  O     . TYR A 1 467 ? 87.545  96.578  105.096 1.00 37.09  ? 459 TYR A O     1 
ATOM   2543  C  CB    . TYR A 1 467 ? 85.197  97.425  106.284 1.00 35.56  ? 459 TYR A CB    1 
ATOM   2544  C  CG    . TYR A 1 467 ? 83.987  97.973  107.002 1.00 36.52  ? 459 TYR A CG    1 
ATOM   2545  C  CD1   . TYR A 1 467 ? 83.561  97.425  108.202 1.00 41.71  ? 459 TYR A CD1   1 
ATOM   2546  C  CD2   . TYR A 1 467 ? 83.265  99.032  106.474 1.00 36.16  ? 459 TYR A CD2   1 
ATOM   2547  C  CE1   . TYR A 1 467 ? 82.453  97.920  108.859 1.00 42.41  ? 459 TYR A CE1   1 
ATOM   2548  C  CE2   . TYR A 1 467 ? 82.157  99.534  107.123 1.00 39.61  ? 459 TYR A CE2   1 
ATOM   2549  C  CZ    . TYR A 1 467 ? 81.756  98.974  108.314 1.00 42.38  ? 459 TYR A CZ    1 
ATOM   2550  O  OH    . TYR A 1 467 ? 80.651  99.472  108.964 1.00 45.60  ? 459 TYR A OH    1 
ATOM   2551  N  N     . PHE A 1 468 ? 88.899  97.840  106.383 1.00 31.33  ? 460 PHE A N     1 
ATOM   2552  C  CA    . PHE A 1 468 ? 90.116  97.338  105.757 1.00 30.19  ? 460 PHE A CA    1 
ATOM   2553  C  C     . PHE A 1 468 ? 90.313  95.845  105.983 1.00 28.87  ? 460 PHE A C     1 
ATOM   2554  O  O     . PHE A 1 468 ? 91.035  95.206  105.211 1.00 30.03  ? 460 PHE A O     1 
ATOM   2555  C  CB    . PHE A 1 468 ? 91.325  98.113  106.280 1.00 32.01  ? 460 PHE A CB    1 
ATOM   2556  C  CG    . PHE A 1 468 ? 92.578  97.891  105.487 1.00 32.91  ? 460 PHE A CG    1 
ATOM   2557  C  CD1   . PHE A 1 468 ? 92.824  98.624  104.340 1.00 34.13  ? 460 PHE A CD1   1 
ATOM   2558  C  CD2   . PHE A 1 468 ? 93.517  96.962  105.895 1.00 32.70  ? 460 PHE A CD2   1 
ATOM   2559  C  CE1   . PHE A 1 468 ? 93.977  98.427  103.610 1.00 34.45  ? 460 PHE A CE1   1 
ATOM   2560  C  CE2   . PHE A 1 468 ? 94.672  96.762  105.169 1.00 36.23  ? 460 PHE A CE2   1 
ATOM   2561  C  CZ    . PHE A 1 468 ? 94.901  97.495  104.025 1.00 36.85  ? 460 PHE A CZ    1 
ATOM   2562  N  N     . LEU A 1 469 ? 89.694  95.276  107.011 1.00 33.64  ? 461 LEU A N     1 
ATOM   2563  C  CA    . LEU A 1 469 ? 89.759  93.849  107.284 1.00 33.49  ? 461 LEU A CA    1 
ATOM   2564  C  C     . LEU A 1 469 ? 88.350  93.273  107.324 1.00 36.23  ? 461 LEU A C     1 
ATOM   2565  O  O     . LEU A 1 469 ? 87.356  94.003  107.325 1.00 39.38  ? 461 LEU A O     1 
ATOM   2566  C  CB    . LEU A 1 469 ? 90.486  93.566  108.604 1.00 27.21  ? 461 LEU A CB    1 
ATOM   2567  C  CG    . LEU A 1 469 ? 91.874  94.184  108.773 1.00 27.06  ? 461 LEU A CG    1 
ATOM   2568  C  CD1   . LEU A 1 469 ? 92.501  93.724  110.074 1.00 34.71  ? 461 LEU A CD1   1 
ATOM   2569  C  CD2   . LEU A 1 469 ? 92.766  93.835  107.602 1.00 30.26  ? 461 LEU A CD2   1 
ATOM   2570  N  N     . HIS A 1 470 ? 88.275  91.945  107.356 1.00 38.25  ? 462 HIS A N     1 
ATOM   2571  C  CA    . HIS A 1 470 ? 86.983  91.272  107.370 1.00 44.26  ? 462 HIS A CA    1 
ATOM   2572  C  C     . HIS A 1 470 ? 86.185  91.670  108.604 1.00 43.74  ? 462 HIS A C     1 
ATOM   2573  O  O     . HIS A 1 470 ? 86.716  91.733  109.716 1.00 47.06  ? 462 HIS A O     1 
ATOM   2574  C  CB    . HIS A 1 470 ? 87.173  89.757  107.330 1.00 49.52  ? 462 HIS A CB    1 
ATOM   2575  C  CG    . HIS A 1 470 ? 85.889  88.990  107.304 1.00 54.52  ? 462 HIS A CG    1 
ATOM   2576  N  ND1   . HIS A 1 470 ? 84.923  89.190  106.343 1.00 53.04  ? 462 HIS A ND1   1 
ATOM   2577  C  CD2   . HIS A 1 470 ? 85.412  88.022  108.122 1.00 59.31  ? 462 HIS A CD2   1 
ATOM   2578  C  CE1   . HIS A 1 470 ? 83.905  88.378  106.569 1.00 55.18  ? 462 HIS A CE1   1 
ATOM   2579  N  NE2   . HIS A 1 470 ? 84.177  87.659  107.643 1.00 62.14  ? 462 HIS A NE2   1 
ATOM   2580  N  N     . TYR A 1 471 ? 84.898  91.940  108.401 1.00 45.10  ? 463 TYR A N     1 
ATOM   2581  C  CA    . TYR A 1 471 ? 84.026  92.458  109.444 1.00 49.38  ? 463 TYR A CA    1 
ATOM   2582  C  C     . TYR A 1 471 ? 82.725  91.673  109.467 1.00 52.99  ? 463 TYR A C     1 
ATOM   2583  O  O     . TYR A 1 471 ? 82.135  91.400  108.418 1.00 51.06  ? 463 TYR A O     1 
ATOM   2584  C  CB    . TYR A 1 471 ? 83.740  93.950  109.220 1.00 45.50  ? 463 TYR A CB    1 
ATOM   2585  C  CG    . TYR A 1 471 ? 82.838  94.586  110.255 1.00 45.54  ? 463 TYR A CG    1 
ATOM   2586  C  CD1   . TYR A 1 471 ? 81.458  94.570  110.108 1.00 48.63  ? 463 TYR A CD1   1 
ATOM   2587  C  CD2   . TYR A 1 471 ? 83.369  95.218  111.369 1.00 43.97  ? 463 TYR A CD2   1 
ATOM   2588  C  CE1   . TYR A 1 471 ? 80.634  95.152  111.047 1.00 49.25  ? 463 TYR A CE1   1 
ATOM   2589  C  CE2   . TYR A 1 471 ? 82.551  95.803  112.312 1.00 51.18  ? 463 TYR A CE2   1 
ATOM   2590  C  CZ    . TYR A 1 471 ? 81.184  95.767  112.146 1.00 53.09  ? 463 TYR A CZ    1 
ATOM   2591  O  OH    . TYR A 1 471 ? 80.364  96.349  113.083 1.00 56.61  ? 463 TYR A OH    1 
ATOM   2592  N  N     . GLU A 1 472 ? 82.282  91.313  110.669 1.00 56.24  ? 464 GLU A N     1 
ATOM   2593  C  CA    . GLU A 1 472 ? 80.988  90.679  110.871 1.00 56.68  ? 464 GLU A CA    1 
ATOM   2594  C  C     . GLU A 1 472 ? 80.321  91.298  112.088 1.00 60.03  ? 464 GLU A C     1 
ATOM   2595  O  O     . GLU A 1 472 ? 80.992  91.733  113.027 1.00 59.10  ? 464 GLU A O     1 
ATOM   2596  C  CB    . GLU A 1 472 ? 81.110  89.161  111.057 1.00 61.57  ? 464 GLU A CB    1 
ATOM   2597  C  CG    . GLU A 1 472 ? 81.579  88.415  109.821 1.00 68.13  ? 464 GLU A CG    1 
ATOM   2598  C  CD    . GLU A 1 472 ? 81.493  86.911  109.982 1.00 74.93  ? 464 GLU A CD    1 
ATOM   2599  O  OE1   . GLU A 1 472 ? 80.848  86.452  110.947 1.00 79.99  ? 464 GLU A OE1   1 
ATOM   2600  O  OE2   . GLU A 1 472 ? 82.072  86.188  109.145 1.00 76.59  ? 464 GLU A OE2   1 
ATOM   2601  N  N     . TYR A 1 473 ? 78.991  91.332  112.065 1.00 65.93  ? 465 TYR A N     1 
ATOM   2602  C  CA    . TYR A 1 473 ? 78.234  91.918  113.161 1.00 69.28  ? 465 TYR A CA    1 
ATOM   2603  C  C     . TYR A 1 473 ? 76.808  91.394  113.120 1.00 76.22  ? 465 TYR A C     1 
ATOM   2604  O  O     . TYR A 1 473 ? 76.261  91.125  112.047 1.00 76.99  ? 465 TYR A O     1 
ATOM   2605  C  CB    . TYR A 1 473 ? 78.243  93.450  113.094 1.00 65.91  ? 465 TYR A CB    1 
ATOM   2606  C  CG    . TYR A 1 473 ? 77.298  94.110  114.071 1.00 71.10  ? 465 TYR A CG    1 
ATOM   2607  C  CD1   . TYR A 1 473 ? 77.643  94.261  115.407 1.00 72.72  ? 465 TYR A CD1   1 
ATOM   2608  C  CD2   . TYR A 1 473 ? 76.059  94.581  113.658 1.00 70.53  ? 465 TYR A CD2   1 
ATOM   2609  C  CE1   . TYR A 1 473 ? 76.780  94.861  116.304 1.00 73.34  ? 465 TYR A CE1   1 
ATOM   2610  C  CE2   . TYR A 1 473 ? 75.190  95.182  114.547 1.00 74.71  ? 465 TYR A CE2   1 
ATOM   2611  C  CZ    . TYR A 1 473 ? 75.555  95.320  115.869 1.00 75.07  ? 465 TYR A CZ    1 
ATOM   2612  O  OH    . TYR A 1 473 ? 74.691  95.919  116.756 1.00 69.09  ? 465 TYR A OH    1 
ATOM   2613  N  N     . GLU A 1 474 ? 76.215  91.253  114.302 1.00 79.70  ? 466 GLU A N     1 
ATOM   2614  C  CA    . GLU A 1 474 ? 74.824  90.872  114.442 1.00 84.34  ? 466 GLU A CA    1 
ATOM   2615  C  C     . GLU A 1 474 ? 74.086  91.933  115.246 1.00 83.67  ? 466 GLU A C     1 
ATOM   2616  O  O     . GLU A 1 474 ? 74.585  92.365  116.295 1.00 83.08  ? 466 GLU A O     1 
ATOM   2617  C  CB    . GLU A 1 474 ? 74.691  89.504  115.130 1.00 90.68  ? 466 GLU A CB    1 
ATOM   2618  C  CG    . GLU A 1 474 ? 75.317  88.359  114.351 1.00 92.91  ? 466 GLU A CG    1 
ATOM   2619  C  CD    . GLU A 1 474 ? 75.061  87.009  114.991 1.00 102.39 ? 466 GLU A CD    1 
ATOM   2620  O  OE1   . GLU A 1 474 ? 74.340  86.958  116.009 1.00 107.88 ? 466 GLU A OE1   1 
ATOM   2621  O  OE2   . GLU A 1 474 ? 75.581  85.997  114.475 1.00 98.67  ? 466 GLU A OE2   1 
ATOM   2622  N  N     . PRO A 1 475 ? 72.919  92.388  114.791 1.00 86.60  ? 467 PRO A N     1 
ATOM   2623  C  CA    . PRO A 1 475 ? 72.199  93.433  115.527 1.00 89.75  ? 467 PRO A CA    1 
ATOM   2624  C  C     . PRO A 1 475 ? 71.778  92.961  116.910 1.00 92.96  ? 467 PRO A C     1 
ATOM   2625  O  O     . PRO A 1 475 ? 71.465  91.788  117.125 1.00 94.92  ? 467 PRO A O     1 
ATOM   2626  C  CB    . PRO A 1 475 ? 70.979  93.717  114.640 1.00 89.18  ? 467 PRO A CB    1 
ATOM   2627  C  CG    . PRO A 1 475 ? 71.358  93.205  113.285 1.00 88.59  ? 467 PRO A CG    1 
ATOM   2628  C  CD    . PRO A 1 475 ? 72.239  92.022  113.539 1.00 86.43  ? 467 PRO A CD    1 
ATOM   2629  N  N     . ALA A 1 476 ? 71.777  93.897  117.855 1.00 91.45  ? 468 ALA A N     1 
ATOM   2630  C  CA    . ALA A 1 476 ? 71.344  93.590  119.210 1.00 90.71  ? 468 ALA A CA    1 
ATOM   2631  C  C     . ALA A 1 476 ? 69.830  93.436  119.263 1.00 95.49  ? 468 ALA A C     1 
ATOM   2632  O  O     . ALA A 1 476 ? 69.088  94.205  118.646 1.00 94.28  ? 468 ALA A O     1 
ATOM   2633  C  CB    . ALA A 1 476 ? 71.796  94.685  120.174 1.00 86.64  ? 468 ALA A CB    1 
ATOM   2634  N  N     . ALA A 1 477 ? 69.372  92.428  120.009 1.00 98.46  ? 469 ALA A N     1 
ATOM   2635  C  CA    . ALA A 1 477 ? 67.937  92.198  120.140 1.00 97.59  ? 469 ALA A CA    1 
ATOM   2636  C  C     . ALA A 1 477 ? 67.254  93.350  120.866 1.00 96.94  ? 469 ALA A C     1 
ATOM   2637  O  O     . ALA A 1 477 ? 66.144  93.752  120.498 1.00 95.46  ? 469 ALA A O     1 
ATOM   2638  C  CB    . ALA A 1 477 ? 67.681  90.878  120.867 1.00 97.74  ? 469 ALA A CB    1 
ATOM   2639  N  N     . ASP A 1 478 ? 67.900  93.892  121.898 1.00 97.47  ? 470 ASP A N     1 
ATOM   2640  C  CA    . ASP A 1 478 ? 67.317  94.971  122.685 1.00 94.43  ? 470 ASP A CA    1 
ATOM   2641  C  C     . ASP A 1 478 ? 67.547  96.348  122.078 1.00 90.49  ? 470 ASP A C     1 
ATOM   2642  O  O     . ASP A 1 478 ? 67.016  97.331  122.607 1.00 86.46  ? 470 ASP A O     1 
ATOM   2643  C  CB    . ASP A 1 478 ? 67.875  94.938  124.109 1.00 91.94  ? 470 ASP A CB    1 
ATOM   2644  C  CG    . ASP A 1 478 ? 69.389  94.895  124.140 1.00 93.02  ? 470 ASP A CG    1 
ATOM   2645  O  OD1   . ASP A 1 478 ? 70.007  94.824  123.057 1.00 92.63  ? 470 ASP A OD1   1 
ATOM   2646  O  OD2   . ASP A 1 478 ? 69.964  94.933  125.248 1.00 91.42  ? 470 ASP A OD2   1 
ATOM   2647  N  N     . SER A 1 479 ? 68.316  96.440  120.991 1.00 90.48  ? 471 SER A N     1 
ATOM   2648  C  CA    . SER A 1 479 ? 68.588  97.709  120.312 1.00 88.76  ? 471 SER A CA    1 
ATOM   2649  C  C     . SER A 1 479 ? 69.214  98.732  121.259 1.00 81.11  ? 471 SER A C     1 
ATOM   2650  O  O     . SER A 1 479 ? 68.884  99.919  121.229 1.00 75.43  ? 471 SER A O     1 
ATOM   2651  C  CB    . SER A 1 479 ? 67.320  98.273  119.666 1.00 97.62  ? 471 SER A CB    1 
ATOM   2652  O  OG    . SER A 1 479 ? 66.775  97.360  118.730 1.00 102.91 ? 471 SER A OG    1 
ATOM   2653  N  N     . THR A 1 480 ? 70.128  98.265  122.114 1.00 81.65  ? 472 THR A N     1 
ATOM   2654  C  CA    . THR A 1 480 ? 70.845  99.136  123.039 1.00 78.86  ? 472 THR A CA    1 
ATOM   2655  C  C     . THR A 1 480 ? 72.353  98.919  122.967 1.00 73.68  ? 472 THR A C     1 
ATOM   2656  O  O     . THR A 1 480 ? 73.066  99.245  123.920 1.00 74.87  ? 472 THR A O     1 
ATOM   2657  C  CB    . THR A 1 480 ? 70.360  98.928  124.477 1.00 81.01  ? 472 THR A CB    1 
ATOM   2658  O  OG1   . THR A 1 480 ? 70.617  97.578  124.881 1.00 85.03  ? 472 THR A OG1   1 
ATOM   2659  C  CG2   . THR A 1 480 ? 68.870  99.211  124.589 1.00 83.28  ? 472 THR A CG2   1 
ATOM   2660  N  N     . ASP A 1 481 ? 72.850  98.377  121.859 1.00 69.49  ? 473 ASP A N     1 
ATOM   2661  C  CA    . ASP A 1 481 ? 74.262  98.045  121.750 1.00 63.76  ? 473 ASP A CA    1 
ATOM   2662  C  C     . ASP A 1 481 ? 75.113  99.307  121.654 1.00 60.07  ? 473 ASP A C     1 
ATOM   2663  O  O     . ASP A 1 481 ? 74.683  100.339 121.132 1.00 60.93  ? 473 ASP A O     1 
ATOM   2664  C  CB    . ASP A 1 481 ? 74.501  97.152  120.535 1.00 62.83  ? 473 ASP A CB    1 
ATOM   2665  C  CG    . ASP A 1 481 ? 75.802  96.381  120.622 1.00 67.79  ? 473 ASP A CG    1 
ATOM   2666  O  OD1   . ASP A 1 481 ? 76.798  96.936  121.131 1.00 68.84  ? 473 ASP A OD1   1 
ATOM   2667  O  OD2   . ASP A 1 481 ? 75.828  95.213  120.181 1.00 74.80  ? 473 ASP A OD2   1 
ATOM   2668  N  N     . VAL A 1 482 ? 76.337  99.213  122.168 1.00 59.43  ? 474 VAL A N     1 
ATOM   2669  C  CA    . VAL A 1 482 ? 77.280  100.323 122.199 1.00 54.34  ? 474 VAL A CA    1 
ATOM   2670  C  C     . VAL A 1 482 ? 78.568  99.886  121.518 1.00 53.32  ? 474 VAL A C     1 
ATOM   2671  O  O     . VAL A 1 482 ? 79.061  98.778  121.756 1.00 54.06  ? 474 VAL A O     1 
ATOM   2672  C  CB    . VAL A 1 482 ? 77.564  100.795 123.640 1.00 52.53  ? 474 VAL A CB    1 
ATOM   2673  C  CG1   . VAL A 1 482 ? 78.489  102.001 123.632 1.00 49.58  ? 474 VAL A CG1   1 
ATOM   2674  C  CG2   . VAL A 1 482 ? 76.267  101.118 124.359 1.00 59.52  ? 474 VAL A CG2   1 
ATOM   2675  N  N     . THR A 1 483 ? 79.109  100.755 120.669 1.00 48.59  ? 475 THR A N     1 
ATOM   2676  C  CA    . THR A 1 483 ? 80.350  100.496 119.954 1.00 45.33  ? 475 THR A CA    1 
ATOM   2677  C  C     . THR A 1 483 ? 81.445  101.408 120.486 1.00 41.66  ? 475 THR A C     1 
ATOM   2678  O  O     . THR A 1 483 ? 81.268  102.629 120.545 1.00 40.43  ? 475 THR A O     1 
ATOM   2679  C  CB    . THR A 1 483 ? 80.177  100.715 118.448 1.00 45.23  ? 475 THR A CB    1 
ATOM   2680  O  OG1   . THR A 1 483 ? 79.414  99.640  117.891 1.00 48.70  ? 475 THR A OG1   1 
ATOM   2681  C  CG2   . THR A 1 483 ? 81.529  100.781 117.754 1.00 39.96  ? 475 THR A CG2   1 
ATOM   2682  N  N     . LEU A 1 484 ? 82.571  100.814 120.869 1.00 38.85  ? 476 LEU A N     1 
ATOM   2683  C  CA    . LEU A 1 484 ? 83.730  101.595 121.277 1.00 34.14  ? 476 LEU A CA    1 
ATOM   2684  C  C     . LEU A 1 484 ? 84.316  102.288 120.054 1.00 35.91  ? 476 LEU A C     1 
ATOM   2685  O  O     . LEU A 1 484 ? 84.733  101.627 119.098 1.00 37.33  ? 476 LEU A O     1 
ATOM   2686  C  CB    . LEU A 1 484 ? 84.766  100.693 121.945 1.00 33.48  ? 476 LEU A CB    1 
ATOM   2687  C  CG    . LEU A 1 484 ? 85.811  101.326 122.869 1.00 35.62  ? 476 LEU A CG    1 
ATOM   2688  C  CD1   . LEU A 1 484 ? 86.369  100.276 123.811 1.00 39.84  ? 476 LEU A CD1   1 
ATOM   2689  C  CD2   . LEU A 1 484 ? 86.938  101.984 122.089 1.00 30.31  ? 476 LEU A CD2   1 
ATOM   2690  N  N     . VAL A 1 485 ? 84.345  103.615 120.080 1.00 34.97  ? 477 VAL A N     1 
ATOM   2691  C  CA    . VAL A 1 485 ? 84.817  104.418 118.960 1.00 29.76  ? 477 VAL A CA    1 
ATOM   2692  C  C     . VAL A 1 485 ? 86.134  105.059 119.365 1.00 33.47  ? 477 VAL A C     1 
ATOM   2693  O  O     . VAL A 1 485 ? 86.204  105.769 120.375 1.00 42.44  ? 477 VAL A O     1 
ATOM   2694  C  CB    . VAL A 1 485 ? 83.787  105.482 118.553 1.00 35.39  ? 477 VAL A CB    1 
ATOM   2695  C  CG1   . VAL A 1 485 ? 84.404  106.472 117.584 1.00 38.50  ? 477 VAL A CG1   1 
ATOM   2696  C  CG2   . VAL A 1 485 ? 82.564  104.823 117.942 1.00 34.86  ? 477 VAL A CG2   1 
ATOM   2697  N  N     . ALA A 1 486 ? 87.177  104.810 118.578 1.00 28.41  ? 478 ALA A N     1 
ATOM   2698  C  CA    . ALA A 1 486 ? 88.488  105.368 118.858 1.00 31.89  ? 478 ALA A CA    1 
ATOM   2699  C  C     . ALA A 1 486 ? 89.254  105.512 117.554 1.00 32.67  ? 478 ALA A C     1 
ATOM   2700  O  O     . ALA A 1 486 ? 88.920  104.893 116.543 1.00 34.77  ? 478 ALA A O     1 
ATOM   2701  C  CB    . ALA A 1 486 ? 89.271  104.500 119.849 1.00 31.86  ? 478 ALA A CB    1 
ATOM   2702  N  N     . GLN A 1 487 ? 90.286  106.348 117.588 1.00 34.94  ? 479 GLN A N     1 
ATOM   2703  C  CA    . GLN A 1 487 ? 91.173  106.524 116.451 1.00 38.65  ? 479 GLN A CA    1 
ATOM   2704  C  C     . GLN A 1 487 ? 92.611  106.485 116.943 1.00 40.51  ? 479 GLN A C     1 
ATOM   2705  O  O     . GLN A 1 487 ? 92.907  106.883 118.072 1.00 41.62  ? 479 GLN A O     1 
ATOM   2706  C  CB    . GLN A 1 487 ? 90.886  107.835 115.708 1.00 38.87  ? 479 GLN A CB    1 
ATOM   2707  C  CG    . GLN A 1 487 ? 90.857  109.068 116.590 1.00 40.73  ? 479 GLN A CG    1 
ATOM   2708  C  CD    . GLN A 1 487 ? 92.228  109.674 116.795 1.00 42.80  ? 479 GLN A CD    1 
ATOM   2709  O  OE1   . GLN A 1 487 ? 93.182  109.330 116.102 1.00 43.11  ? 479 GLN A OE1   1 
ATOM   2710  N  NE2   . GLN A 1 487 ? 92.333  110.584 117.754 1.00 42.54  ? 479 GLN A NE2   1 
ATOM   2711  N  N     . LEU A 1 488 ? 93.503  106.002 116.083 1.00 40.64  ? 480 LEU A N     1 
ATOM   2712  C  CA    . LEU A 1 488 ? 94.895  105.829 116.469 1.00 40.73  ? 480 LEU A CA    1 
ATOM   2713  C  C     . LEU A 1 488 ? 95.781  105.959 115.243 1.00 43.70  ? 480 LEU A C     1 
ATOM   2714  O  O     . LEU A 1 488 ? 95.325  105.829 114.105 1.00 40.98  ? 480 LEU A O     1 
ATOM   2715  C  CB    . LEU A 1 488 ? 95.132  104.472 117.139 1.00 39.56  ? 480 LEU A CB    1 
ATOM   2716  C  CG    . LEU A 1 488 ? 95.076  103.239 116.234 1.00 41.91  ? 480 LEU A CG    1 
ATOM   2717  C  CD1   . LEU A 1 488 ? 95.855  102.095 116.854 1.00 40.85  ? 480 LEU A CD1   1 
ATOM   2718  C  CD2   . LEU A 1 488 ? 93.640  102.814 115.969 1.00 39.28  ? 480 LEU A CD2   1 
ATOM   2719  N  N     . SER A 1 489 ? 97.056  106.222 115.497 1.00 48.81  ? 481 SER A N     1 
ATOM   2720  C  CA    . SER A 1 489 ? 98.094  106.144 114.487 1.00 45.58  ? 481 SER A CA    1 
ATOM   2721  C  C     . SER A 1 489 ? 98.856  104.832 114.669 1.00 49.13  ? 481 SER A C     1 
ATOM   2722  O  O     . SER A 1 489 ? 98.483  103.979 115.480 1.00 53.39  ? 481 SER A O     1 
ATOM   2723  C  CB    . SER A 1 489 ? 99.010  107.365 114.567 1.00 48.72  ? 481 SER A CB    1 
ATOM   2724  O  OG    . SER A 1 489 ? 99.594  107.478 115.852 1.00 59.64  ? 481 SER A OG    1 
ATOM   2725  N  N     . MET A 1 490 ? 99.933  104.659 113.900 1.00 53.17  ? 482 MET A N     1 
ATOM   2726  C  CA    . MET A 1 490 ? 100.683 103.406 113.943 1.00 53.07  ? 482 MET A CA    1 
ATOM   2727  C  C     . MET A 1 490 ? 101.302 103.179 115.316 1.00 55.28  ? 482 MET A C     1 
ATOM   2728  O  O     . MET A 1 490 ? 101.212 102.082 115.881 1.00 55.03  ? 482 MET A O     1 
ATOM   2729  C  CB    . MET A 1 490 ? 101.762 103.412 112.861 1.00 50.33  ? 482 MET A CB    1 
ATOM   2730  C  CG    . MET A 1 490 ? 102.425 102.068 112.637 1.00 53.18  ? 482 MET A CG    1 
ATOM   2731  S  SD    . MET A 1 490 ? 101.358 100.903 111.773 1.00 60.36  ? 482 MET A SD    1 
ATOM   2732  C  CE    . MET A 1 490 ? 102.481 99.525  111.570 1.00 53.99  ? 482 MET A CE    1 
ATOM   2733  N  N     . ASP A 1 491 ? 101.910 104.220 115.887 1.00 53.70  ? 483 ASP A N     1 
ATOM   2734  C  CA    . ASP A 1 491 ? 102.643 104.099 117.141 1.00 53.13  ? 483 ASP A CA    1 
ATOM   2735  C  C     . ASP A 1 491 ? 101.755 103.767 118.335 1.00 55.62  ? 483 ASP A C     1 
ATOM   2736  O  O     . ASP A 1 491 ? 102.258 103.742 119.463 1.00 55.73  ? 483 ASP A O     1 
ATOM   2737  C  CB    . ASP A 1 491 ? 103.420 105.388 117.413 1.00 57.14  ? 483 ASP A CB    1 
ATOM   2738  C  CG    . ASP A 1 491 ? 102.545 106.623 117.349 1.00 62.72  ? 483 ASP A CG    1 
ATOM   2739  O  OD1   . ASP A 1 491 ? 101.321 106.480 117.154 1.00 63.20  ? 483 ASP A OD1   1 
ATOM   2740  O  OD2   . ASP A 1 491 ? 103.083 107.741 117.494 1.00 69.96  ? 483 ASP A OD2   1 
ATOM   2741  N  N     . ARG A 1 492 ? 100.462 103.526 118.127 1.00 53.91  ? 484 ARG A N     1 
ATOM   2742  C  CA    . ARG A 1 492 ? 99.557  103.119 119.193 1.00 52.93  ? 484 ARG A CA    1 
ATOM   2743  C  C     . ARG A 1 492 ? 99.070  101.686 119.033 1.00 51.76  ? 484 ARG A C     1 
ATOM   2744  O  O     . ARG A 1 492 ? 98.210  101.248 119.807 1.00 50.06  ? 484 ARG A O     1 
ATOM   2745  C  CB    . ARG A 1 492 ? 98.358  104.065 119.257 1.00 52.88  ? 484 ARG A CB    1 
ATOM   2746  C  CG    . ARG A 1 492 ? 98.710  105.529 119.425 1.00 51.85  ? 484 ARG A CG    1 
ATOM   2747  C  CD    . ARG A 1 492 ? 99.424  105.784 120.737 1.00 51.35  ? 484 ARG A CD    1 
ATOM   2748  N  NE    . ARG A 1 492 ? 99.274  107.169 121.168 1.00 48.72  ? 484 ARG A NE    1 
ATOM   2749  C  CZ    . ARG A 1 492 ? 100.004 108.179 120.714 1.00 53.44  ? 484 ARG A CZ    1 
ATOM   2750  N  NH1   . ARG A 1 492 ? 100.946 107.996 119.803 1.00 56.54  ? 484 ARG A NH1   1 
ATOM   2751  N  NH2   . ARG A 1 492 ? 99.781  109.402 121.183 1.00 53.54  ? 484 ARG A NH2   1 
ATOM   2752  N  N     . LEU A 1 493 ? 99.601  100.942 118.055 1.00 49.40  ? 485 LEU A N     1 
ATOM   2753  C  CA    . LEU A 1 493 ? 99.077  99.609  117.765 1.00 48.65  ? 485 LEU A CA    1 
ATOM   2754  C  C     . LEU A 1 493 ? 99.114  98.698  118.985 1.00 52.54  ? 485 LEU A C     1 
ATOM   2755  O  O     . LEU A 1 493 ? 98.228  97.850  119.151 1.00 51.49  ? 485 LEU A O     1 
ATOM   2756  C  CB    . LEU A 1 493 ? 99.857  98.969  116.618 1.00 47.63  ? 485 LEU A CB    1 
ATOM   2757  C  CG    . LEU A 1 493 ? 99.533  99.434  115.200 1.00 52.29  ? 485 LEU A CG    1 
ATOM   2758  C  CD1   . LEU A 1 493 ? 100.193 98.513  114.192 1.00 50.89  ? 485 LEU A CD1   1 
ATOM   2759  C  CD2   . LEU A 1 493 ? 98.033  99.482  114.979 1.00 52.03  ? 485 LEU A CD2   1 
ATOM   2760  N  N     . GLN A 1 494 ? 100.111 98.869  119.855 1.00 53.56  ? 486 GLN A N     1 
ATOM   2761  C  CA    . GLN A 1 494 ? 100.239 98.010  121.027 1.00 52.77  ? 486 GLN A CA    1 
ATOM   2762  C  C     . GLN A 1 494 ? 99.018  98.078  121.931 1.00 54.78  ? 486 GLN A C     1 
ATOM   2763  O  O     . GLN A 1 494 ? 98.788  97.148  122.712 1.00 56.82  ? 486 GLN A O     1 
ATOM   2764  C  CB    . GLN A 1 494 ? 101.489 98.383  121.824 1.00 56.79  ? 486 GLN A CB    1 
ATOM   2765  C  CG    . GLN A 1 494 ? 101.532 99.827  122.296 1.00 59.17  ? 486 GLN A CG    1 
ATOM   2766  C  CD    . GLN A 1 494 ? 102.072 100.772 121.241 1.00 61.06  ? 486 GLN A CD    1 
ATOM   2767  O  OE1   . GLN A 1 494 ? 102.435 100.351 120.143 1.00 56.85  ? 486 GLN A OE1   1 
ATOM   2768  N  NE2   . GLN A 1 494 ? 102.131 102.057 121.571 1.00 63.39  ? 486 GLN A NE2   1 
ATOM   2769  N  N     . MET A 1 495 ? 98.231  99.151  121.844 1.00 52.83  ? 487 MET A N     1 
ATOM   2770  C  CA    . MET A 1 495 ? 97.037  99.244  122.674 1.00 49.82  ? 487 MET A CA    1 
ATOM   2771  C  C     . MET A 1 495 ? 95.934  98.313  122.189 1.00 48.32  ? 487 MET A C     1 
ATOM   2772  O  O     . MET A 1 495 ? 95.162  97.800  123.009 1.00 46.95  ? 487 MET A O     1 
ATOM   2773  C  CB    . MET A 1 495 ? 96.535  100.686 122.708 1.00 49.07  ? 487 MET A CB    1 
ATOM   2774  C  CG    . MET A 1 495 ? 97.515  101.670 123.322 1.00 54.21  ? 487 MET A CG    1 
ATOM   2775  S  SD    . MET A 1 495 ? 97.975  101.234 125.009 1.00 68.26  ? 487 MET A SD    1 
ATOM   2776  C  CE    . MET A 1 495 ? 96.368  101.150 125.794 1.00 49.74  ? 487 MET A CE    1 
ATOM   2777  N  N     . LEU A 1 496 ? 95.869  98.058  120.878 1.00 46.88  ? 488 LEU A N     1 
ATOM   2778  C  CA    . LEU A 1 496 ? 94.687  97.428  120.291 1.00 44.96  ? 488 LEU A CA    1 
ATOM   2779  C  C     . LEU A 1 496 ? 94.347  96.114  120.979 1.00 46.20  ? 488 LEU A C     1 
ATOM   2780  O  O     . LEU A 1 496 ? 93.226  95.930  121.470 1.00 47.94  ? 488 LEU A O     1 
ATOM   2781  C  CB    . LEU A 1 496 ? 94.903  97.198  118.795 1.00 42.65  ? 488 LEU A CB    1 
ATOM   2782  C  CG    . LEU A 1 496 ? 94.980  98.432  117.900 1.00 42.34  ? 488 LEU A CG    1 
ATOM   2783  C  CD1   . LEU A 1 496 ? 95.016  98.018  116.441 1.00 42.66  ? 488 LEU A CD1   1 
ATOM   2784  C  CD2   . LEU A 1 496 ? 93.807  99.351  118.168 1.00 40.86  ? 488 LEU A CD2   1 
ATOM   2785  N  N     . GLU A 1 497 ? 95.321  95.205  121.066 1.00 47.75  ? 489 GLU A N     1 
ATOM   2786  C  CA    . GLU A 1 497 ? 95.068  93.916  121.699 1.00 49.93  ? 489 GLU A CA    1 
ATOM   2787  C  C     . GLU A 1 497 ? 94.576  94.100  123.125 1.00 48.73  ? 489 GLU A C     1 
ATOM   2788  O  O     . GLU A 1 497 ? 93.587  93.478  123.533 1.00 50.10  ? 489 GLU A O     1 
ATOM   2789  C  CB    . GLU A 1 497 ? 96.330  93.055  121.673 1.00 54.48  ? 489 GLU A CB    1 
ATOM   2790  C  CG    . GLU A 1 497 ? 96.757  92.617  120.284 1.00 56.99  ? 489 GLU A CG    1 
ATOM   2791  C  CD    . GLU A 1 497 ? 97.946  91.676  120.311 1.00 60.72  ? 489 GLU A CD    1 
ATOM   2792  O  OE1   . GLU A 1 497 ? 98.480  91.420  121.411 1.00 59.44  ? 489 GLU A OE1   1 
ATOM   2793  O  OE2   . GLU A 1 497 ? 98.345  91.190  119.232 1.00 62.84  ? 489 GLU A OE2   1 
ATOM   2794  N  N     . ALA A 1 498 ? 95.226  94.987  123.882 1.00 47.17  ? 490 ALA A N     1 
ATOM   2795  C  CA    . ALA A 1 498 ? 94.784  95.259  125.243 1.00 46.33  ? 490 ALA A CA    1 
ATOM   2796  C  C     . ALA A 1 498 ? 93.325  95.688  125.255 1.00 48.31  ? 490 ALA A C     1 
ATOM   2797  O  O     . ALA A 1 498 ? 92.522  95.182  126.049 1.00 49.16  ? 490 ALA A O     1 
ATOM   2798  C  CB    . ALA A 1 498 ? 95.671  96.328  125.879 1.00 47.60  ? 490 ALA A CB    1 
ATOM   2799  N  N     . ILE A 1 499 ? 92.953  96.590  124.343 1.00 46.76  ? 491 ILE A N     1 
ATOM   2800  C  CA    . ILE A 1 499 ? 91.563  97.021  124.259 1.00 46.10  ? 491 ILE A CA    1 
ATOM   2801  C  C     . ILE A 1 499 ? 90.667  95.837  123.936 1.00 48.80  ? 491 ILE A C     1 
ATOM   2802  O  O     . ILE A 1 499 ? 89.600  95.663  124.538 1.00 50.68  ? 491 ILE A O     1 
ATOM   2803  C  CB    . ILE A 1 499 ? 91.414  98.152  123.226 1.00 46.88  ? 491 ILE A CB    1 
ATOM   2804  C  CG1   . ILE A 1 499 ? 92.221  99.373  123.665 1.00 48.55  ? 491 ILE A CG1   1 
ATOM   2805  C  CG2   . ILE A 1 499 ? 89.952  98.514  123.039 1.00 44.87  ? 491 ILE A CG2   1 
ATOM   2806  C  CD1   . ILE A 1 499 ? 92.051  100.573 122.769 1.00 43.55  ? 491 ILE A CD1   1 
ATOM   2807  N  N     . CYS A 1 500 ? 91.100  94.983  123.007 1.00 47.86  ? 492 CYS A N     1 
ATOM   2808  C  CA    . CYS A 1 500 ? 90.307  93.811  122.667 1.00 46.97  ? 492 CYS A CA    1 
ATOM   2809  C  C     . CYS A 1 500 ? 90.186  92.849  123.838 1.00 50.87  ? 492 CYS A C     1 
ATOM   2810  O  O     . CYS A 1 500 ? 89.262  92.029  123.859 1.00 52.16  ? 492 CYS A O     1 
ATOM   2811  C  CB    . CYS A 1 500 ? 90.912  93.099  121.457 1.00 52.19  ? 492 CYS A CB    1 
ATOM   2812  S  SG    . CYS A 1 500 ? 90.947  94.099  119.951 1.00 56.98  ? 492 CYS A SG    1 
ATOM   2813  N  N     . LYS A 1 501 ? 91.095  92.929  124.812 1.00 51.93  ? 493 LYS A N     1 
ATOM   2814  C  CA    . LYS A 1 501 ? 90.980  92.092  125.997 1.00 50.86  ? 493 LYS A CA    1 
ATOM   2815  C  C     . LYS A 1 501 ? 90.039  92.680  127.038 1.00 52.59  ? 493 LYS A C     1 
ATOM   2816  O  O     . LYS A 1 501 ? 89.626  91.962  127.955 1.00 56.09  ? 493 LYS A O     1 
ATOM   2817  C  CB    . LYS A 1 501 ? 92.359  91.861  126.617 1.00 52.52  ? 493 LYS A CB    1 
ATOM   2818  C  CG    . LYS A 1 501 ? 93.303  91.058  125.738 1.00 55.22  ? 493 LYS A CG    1 
ATOM   2819  C  CD    . LYS A 1 501 ? 94.627  90.808  126.437 1.00 55.23  ? 493 LYS A CD    1 
ATOM   2820  C  CE    . LYS A 1 501 ? 95.562  89.988  125.567 1.00 56.13  ? 493 LYS A CE    1 
ATOM   2821  N  NZ    . LYS A 1 501 ? 96.855  89.718  126.251 1.00 67.30  ? 493 LYS A NZ    1 
ATOM   2822  N  N     . HIS A 1 502 ? 89.684  93.958  126.914 1.00 50.14  ? 494 HIS A N     1 
ATOM   2823  C  CA    . HIS A 1 502 ? 88.792  94.608  127.864 1.00 50.22  ? 494 HIS A CA    1 
ATOM   2824  C  C     . HIS A 1 502 ? 87.377  94.783  127.332 1.00 54.32  ? 494 HIS A C     1 
ATOM   2825  O  O     . HIS A 1 502 ? 86.414  94.639  128.090 1.00 59.72  ? 494 HIS A O     1 
ATOM   2826  C  CB    . HIS A 1 502 ? 89.349  95.977  128.265 1.00 52.69  ? 494 HIS A CB    1 
ATOM   2827  C  CG    . HIS A 1 502 ? 90.533  95.908  129.178 1.00 57.80  ? 494 HIS A CG    1 
ATOM   2828  N  ND1   . HIS A 1 502 ? 90.491  95.285  130.406 1.00 59.25  ? 494 HIS A ND1   1 
ATOM   2829  C  CD2   . HIS A 1 502 ? 91.787  96.402  129.050 1.00 56.00  ? 494 HIS A CD2   1 
ATOM   2830  C  CE1   . HIS A 1 502 ? 91.671  95.389  130.991 1.00 58.05  ? 494 HIS A CE1   1 
ATOM   2831  N  NE2   . HIS A 1 502 ? 92.475  96.062  130.189 1.00 58.02  ? 494 HIS A NE2   1 
ATOM   2832  N  N     . TRP A 1 503 ? 87.228  95.087  126.046 1.00 49.53  ? 495 TRP A N     1 
ATOM   2833  C  CA    . TRP A 1 503 ? 85.934  95.380  125.441 1.00 45.43  ? 495 TRP A CA    1 
ATOM   2834  C  C     . TRP A 1 503 ? 85.543  94.215  124.540 1.00 49.58  ? 495 TRP A C     1 
ATOM   2835  O  O     . TRP A 1 503 ? 86.197  93.965  123.523 1.00 51.17  ? 495 TRP A O     1 
ATOM   2836  C  CB    . TRP A 1 503 ? 85.992  96.689  124.657 1.00 42.04  ? 495 TRP A CB    1 
ATOM   2837  C  CG    . TRP A 1 503 ? 84.663  97.151  124.155 1.00 44.34  ? 495 TRP A CG    1 
ATOM   2838  C  CD1   . TRP A 1 503 ? 84.075  96.818  122.973 1.00 44.51  ? 495 TRP A CD1   1 
ATOM   2839  C  CD2   . TRP A 1 503 ? 83.755  98.036  124.820 1.00 45.61  ? 495 TRP A CD2   1 
ATOM   2840  N  NE1   . TRP A 1 503 ? 82.856  97.438  122.859 1.00 42.95  ? 495 TRP A NE1   1 
ATOM   2841  C  CE2   . TRP A 1 503 ? 82.636  98.192  123.982 1.00 44.86  ? 495 TRP A CE2   1 
ATOM   2842  C  CE3   . TRP A 1 503 ? 83.779  98.710  126.044 1.00 45.35  ? 495 TRP A CE3   1 
ATOM   2843  C  CZ2   . TRP A 1 503 ? 81.551  98.994  124.327 1.00 44.73  ? 495 TRP A CZ2   1 
ATOM   2844  C  CZ3   . TRP A 1 503 ? 82.703  99.505  126.384 1.00 43.46  ? 495 TRP A CZ3   1 
ATOM   2845  C  CH2   . TRP A 1 503 ? 81.604  99.641  125.529 1.00 42.98  ? 495 TRP A CH2   1 
ATOM   2846  N  N     . GLU A 1 504 ? 84.480  93.508  124.912 1.00 50.41  ? 496 GLU A N     1 
ATOM   2847  C  CA    . GLU A 1 504 ? 83.992  92.379  124.134 1.00 48.00  ? 496 GLU A CA    1 
ATOM   2848  C  C     . GLU A 1 504 ? 82.971  92.783  123.080 1.00 47.55  ? 496 GLU A C     1 
ATOM   2849  O  O     . GLU A 1 504 ? 82.547  91.932  122.291 1.00 47.44  ? 496 GLU A O     1 
ATOM   2850  C  CB    . GLU A 1 504 ? 83.374  91.322  125.055 1.00 51.83  ? 496 GLU A CB    1 
ATOM   2851  C  CG    . GLU A 1 504 ? 84.094  91.142  126.379 1.00 59.00  ? 496 GLU A CG    1 
ATOM   2852  C  CD    . GLU A 1 504 ? 83.542  92.046  127.465 1.00 67.19  ? 496 GLU A CD    1 
ATOM   2853  O  OE1   . GLU A 1 504 ? 82.415  92.556  127.297 1.00 66.59  ? 496 GLU A OE1   1 
ATOM   2854  O  OE2   . GLU A 1 504 ? 84.236  92.247  128.485 1.00 67.74  ? 496 GLU A OE2   1 
ATOM   2855  N  N     . GLY A 1 505 ? 82.564  94.049  123.049 1.00 48.64  ? 497 GLY A N     1 
ATOM   2856  C  CA    . GLY A 1 505 ? 81.570  94.507  122.110 1.00 47.29  ? 497 GLY A CA    1 
ATOM   2857  C  C     . GLY A 1 505 ? 82.177  95.029  120.826 1.00 46.44  ? 497 GLY A C     1 
ATOM   2858  O  O     . GLY A 1 505 ? 83.396  95.009  120.633 1.00 47.85  ? 497 GLY A O     1 
ATOM   2859  N  N     . PRO A 1 506 ? 81.328  95.500  119.914 1.00 46.31  ? 498 PRO A N     1 
ATOM   2860  C  CA    . PRO A 1 506 ? 81.832  96.024  118.639 1.00 42.12  ? 498 PRO A CA    1 
ATOM   2861  C  C     . PRO A 1 506 ? 82.726  97.238  118.843 1.00 39.49  ? 498 PRO A C     1 
ATOM   2862  O  O     . PRO A 1 506 ? 82.495  98.066  119.725 1.00 43.85  ? 498 PRO A O     1 
ATOM   2863  C  CB    . PRO A 1 506 ? 80.554  96.385  117.874 1.00 45.07  ? 498 PRO A CB    1 
ATOM   2864  C  CG    . PRO A 1 506 ? 79.508  96.539  118.926 1.00 48.67  ? 498 PRO A CG    1 
ATOM   2865  C  CD    . PRO A 1 506 ? 79.861  95.558  119.996 1.00 48.14  ? 498 PRO A CD    1 
ATOM   2866  N  N     . ILE A 1 507 ? 83.759  97.333  118.010 1.00 34.83  ? 499 ILE A N     1 
ATOM   2867  C  CA    . ILE A 1 507 ? 84.732  98.416  118.065 1.00 31.10  ? 499 ILE A CA    1 
ATOM   2868  C  C     . ILE A 1 507 ? 84.856  99.017  116.674 1.00 32.58  ? 499 ILE A C     1 
ATOM   2869  O  O     . ILE A 1 507 ? 84.876  98.289  115.675 1.00 41.08  ? 499 ILE A O     1 
ATOM   2870  C  CB    . ILE A 1 507 ? 86.106  97.927  118.569 1.00 34.39  ? 499 ILE A CB    1 
ATOM   2871  C  CG1   . ILE A 1 507 ? 85.958  97.157  119.881 1.00 38.02  ? 499 ILE A CG1   1 
ATOM   2872  C  CG2   . ILE A 1 507 ? 87.060  99.095  118.750 1.00 30.73  ? 499 ILE A CG2   1 
ATOM   2873  C  CD1   . ILE A 1 507 ? 87.264  96.642  120.436 1.00 36.08  ? 499 ILE A CD1   1 
ATOM   2874  N  N     . SER A 1 508 ? 84.925  100.343 116.605 1.00 32.17  ? 500 SER A N     1 
ATOM   2875  C  CA    . SER A 1 508 ? 85.114  101.062 115.350 1.00 29.19  ? 500 SER A CA    1 
ATOM   2876  C  C     . SER A 1 508 ? 86.365  101.919 115.482 1.00 28.42  ? 500 SER A C     1 
ATOM   2877  O  O     . SER A 1 508 ? 86.402  102.851 116.291 1.00 35.45  ? 500 SER A O     1 
ATOM   2878  C  CB    . SER A 1 508 ? 83.894  101.916 115.015 1.00 33.59  ? 500 SER A CB    1 
ATOM   2879  O  OG    . SER A 1 508 ? 84.091  102.638 113.813 1.00 36.27  ? 500 SER A OG    1 
ATOM   2880  N  N     . LEU A 1 509 ? 87.383  101.608 114.688 1.00 26.99  ? 501 LEU A N     1 
ATOM   2881  C  CA    . LEU A 1 509 ? 88.672  102.275 114.770 1.00 28.93  ? 501 LEU A CA    1 
ATOM   2882  C  C     . LEU A 1 509 ? 88.998  102.951 113.448 1.00 29.67  ? 501 LEU A C     1 
ATOM   2883  O  O     . LEU A 1 509 ? 88.613  102.477 112.377 1.00 34.02  ? 501 LEU A O     1 
ATOM   2884  C  CB    . LEU A 1 509 ? 89.783  101.285 115.131 1.00 29.54  ? 501 LEU A CB    1 
ATOM   2885  C  CG    . LEU A 1 509 ? 89.590  100.495 116.424 1.00 29.40  ? 501 LEU A CG    1 
ATOM   2886  C  CD1   . LEU A 1 509 ? 90.587  99.359  116.495 1.00 36.16  ? 501 LEU A CD1   1 
ATOM   2887  C  CD2   . LEU A 1 509 ? 89.728  101.403 117.632 1.00 30.02  ? 501 LEU A CD2   1 
ATOM   2888  N  N     . ALA A 1 510 ? 89.713  104.070 113.534 1.00 30.99  ? 502 ALA A N     1 
ATOM   2889  C  CA    . ALA A 1 510 ? 90.184  104.802 112.364 1.00 30.66  ? 502 ALA A CA    1 
ATOM   2890  C  C     . ALA A 1 510 ? 91.698  104.924 112.461 1.00 35.81  ? 502 ALA A C     1 
ATOM   2891  O  O     . ALA A 1 510 ? 92.213  105.616 113.345 1.00 40.61  ? 502 ALA A O     1 
ATOM   2892  C  CB    . ALA A 1 510 ? 89.526  106.176 112.269 1.00 32.99  ? 502 ALA A CB    1 
ATOM   2893  N  N     . LEU A 1 511 ? 92.406  104.262 111.552 1.00 35.39  ? 503 LEU A N     1 
ATOM   2894  C  CA    . LEU A 1 511 ? 93.861  104.219 111.571 1.00 36.19  ? 503 LEU A CA    1 
ATOM   2895  C  C     . LEU A 1 511 ? 94.421  105.149 110.502 1.00 36.44  ? 503 LEU A C     1 
ATOM   2896  O  O     . LEU A 1 511 ? 94.042  105.056 109.331 1.00 35.28  ? 503 LEU A O     1 
ATOM   2897  C  CB    . LEU A 1 511 ? 94.368  102.793 111.349 1.00 38.34  ? 503 LEU A CB    1 
ATOM   2898  C  CG    . LEU A 1 511 ? 93.977  101.733 112.384 1.00 35.07  ? 503 LEU A CG    1 
ATOM   2899  C  CD1   . LEU A 1 511 ? 92.653  101.071 112.036 1.00 33.65  ? 503 LEU A CD1   1 
ATOM   2900  C  CD2   . LEU A 1 511 ? 95.074  100.695 112.522 1.00 38.77  ? 503 LEU A CD2   1 
ATOM   2901  N  N     . TYR A 1 512 ? 95.323  106.040 110.911 1.00 41.06  ? 504 TYR A N     1 
ATOM   2902  C  CA    . TYR A 1 512 ? 95.953  106.997 110.003 1.00 42.32  ? 504 TYR A CA    1 
ATOM   2903  C  C     . TYR A 1 512 ? 97.312  106.436 109.592 1.00 46.67  ? 504 TYR A C     1 
ATOM   2904  O  O     . TYR A 1 512 ? 98.356  106.782 110.143 1.00 50.10  ? 504 TYR A O     1 
ATOM   2905  C  CB    . TYR A 1 512 ? 96.073  108.362 110.669 1.00 42.63  ? 504 TYR A CB    1 
ATOM   2906  C  CG    . TYR A 1 512 ? 96.486  109.475 109.735 1.00 48.63  ? 504 TYR A CG    1 
ATOM   2907  C  CD1   . TYR A 1 512 ? 95.665  109.868 108.689 1.00 50.56  ? 504 TYR A CD1   1 
ATOM   2908  C  CD2   . TYR A 1 512 ? 97.686  110.146 109.912 1.00 50.38  ? 504 TYR A CD2   1 
ATOM   2909  C  CE1   . TYR A 1 512 ? 96.033  110.886 107.837 1.00 54.23  ? 504 TYR A CE1   1 
ATOM   2910  C  CE2   . TYR A 1 512 ? 98.063  111.169 109.066 1.00 51.68  ? 504 TYR A CE2   1 
ATOM   2911  C  CZ    . TYR A 1 512 ? 97.232  111.535 108.031 1.00 56.79  ? 504 TYR A CZ    1 
ATOM   2912  O  OH    . TYR A 1 512 ? 97.600  112.553 107.183 1.00 62.45  ? 504 TYR A OH    1 
ATOM   2913  N  N     . LEU A 1 513 ? 97.285  105.555 108.595 1.00 46.70  ? 505 LEU A N     1 
ATOM   2914  C  CA    . LEU A 1 513 ? 98.460  104.816 108.161 1.00 46.85  ? 505 LEU A CA    1 
ATOM   2915  C  C     . LEU A 1 513 ? 98.774  105.122 106.705 1.00 48.28  ? 505 LEU A C     1 
ATOM   2916  O  O     . LEU A 1 513 ? 97.880  105.422 105.911 1.00 53.89  ? 505 LEU A O     1 
ATOM   2917  C  CB    . LEU A 1 513 ? 98.248  103.309 108.321 1.00 43.66  ? 505 LEU A CB    1 
ATOM   2918  C  CG    . LEU A 1 513 ? 97.640  102.843 109.640 1.00 41.97  ? 505 LEU A CG    1 
ATOM   2919  C  CD1   . LEU A 1 513 ? 97.308  101.365 109.572 1.00 44.23  ? 505 LEU A CD1   1 
ATOM   2920  C  CD2   . LEU A 1 513 ? 98.587  103.132 110.789 1.00 45.34  ? 505 LEU A CD2   1 
ATOM   2921  N  N     . SER A 1 514 ? 100.056 105.041 106.359 1.00 50.09  ? 506 SER A N     1 
ATOM   2922  C  CA    . SER A 1 514 ? 100.463 105.080 104.964 1.00 53.66  ? 506 SER A CA    1 
ATOM   2923  C  C     . SER A 1 514 ? 100.325 103.686 104.356 1.00 54.64  ? 506 SER A C     1 
ATOM   2924  O  O     . SER A 1 514 ? 99.996  102.714 105.040 1.00 58.08  ? 506 SER A O     1 
ATOM   2925  C  CB    . SER A 1 514 ? 101.890 105.606 104.835 1.00 56.02  ? 506 SER A CB    1 
ATOM   2926  O  OG    . SER A 1 514 ? 102.820 104.701 105.400 1.00 61.83  ? 506 SER A OG    1 
ATOM   2927  N  N     . ASP A 1 515 ? 100.575 103.582 103.049 1.00 53.47  ? 507 ASP A N     1 
ATOM   2928  C  CA    . ASP A 1 515 ? 100.410 102.301 102.368 1.00 56.29  ? 507 ASP A CA    1 
ATOM   2929  C  C     . ASP A 1 515 ? 101.356 101.247 102.932 1.00 60.26  ? 507 ASP A C     1 
ATOM   2930  O  O     . ASP A 1 515 ? 100.947 100.107 103.192 1.00 60.78  ? 507 ASP A O     1 
ATOM   2931  C  CB    . ASP A 1 515 ? 100.630 102.474 100.867 1.00 63.47  ? 507 ASP A CB    1 
ATOM   2932  C  CG    . ASP A 1 515 ? 99.665  103.466 100.249 1.00 62.91  ? 507 ASP A CG    1 
ATOM   2933  O  OD1   . ASP A 1 515 ? 99.877  104.686 100.410 1.00 63.81  ? 507 ASP A OD1   1 
ATOM   2934  O  OD2   . ASP A 1 515 ? 98.690  103.026 99.605  1.00 57.05  ? 507 ASP A OD2   1 
ATOM   2935  N  N     . ALA A 1 516 ? 102.623 101.612 103.137 1.00 62.86  ? 508 ALA A N     1 
ATOM   2936  C  CA    . ALA A 1 516 ? 103.555 100.696 103.784 1.00 60.98  ? 508 ALA A CA    1 
ATOM   2937  C  C     . ALA A 1 516 ? 103.109 100.380 105.204 1.00 57.79  ? 508 ALA A C     1 
ATOM   2938  O  O     . ALA A 1 516 ? 103.123 99.217  105.625 1.00 60.37  ? 508 ALA A O     1 
ATOM   2939  C  CB    . ALA A 1 516 ? 104.963 101.290 103.779 1.00 63.95  ? 508 ALA A CB    1 
ATOM   2940  N  N     . GLU A 1 517 ? 102.696 101.404 105.955 1.00 54.55  ? 509 GLU A N     1 
ATOM   2941  C  CA    . GLU A 1 517 ? 102.170 101.169 107.293 1.00 52.43  ? 509 GLU A CA    1 
ATOM   2942  C  C     . GLU A 1 517 ? 100.869 100.382 107.252 1.00 50.39  ? 509 GLU A C     1 
ATOM   2943  O  O     . GLU A 1 517 ? 100.598 99.595  108.164 1.00 50.97  ? 509 GLU A O     1 
ATOM   2944  C  CB    . GLU A 1 517 ? 101.968 102.495 108.023 1.00 52.83  ? 509 GLU A CB    1 
ATOM   2945  C  CG    . GLU A 1 517 ? 103.250 103.267 108.264 1.00 55.82  ? 509 GLU A CG    1 
ATOM   2946  C  CD    . GLU A 1 517 ? 103.018 104.552 109.031 1.00 62.96  ? 509 GLU A CD    1 
ATOM   2947  O  OE1   . GLU A 1 517 ? 101.939 104.692 109.642 1.00 61.94  ? 509 GLU A OE1   1 
ATOM   2948  O  OE2   . GLU A 1 517 ? 103.913 105.423 109.019 1.00 67.04  ? 509 GLU A OE2   1 
ATOM   2949  N  N     . ALA A 1 518 ? 100.055 100.574 106.212 1.00 53.02  ? 510 ALA A N     1 
ATOM   2950  C  CA    . ALA A 1 518 ? 98.843  99.774  106.075 1.00 52.06  ? 510 ALA A CA    1 
ATOM   2951  C  C     . ALA A 1 518 ? 99.178  98.300  105.902 1.00 53.57  ? 510 ALA A C     1 
ATOM   2952  O  O     . ALA A 1 518 ? 98.539  97.435  106.511 1.00 56.95  ? 510 ALA A O     1 
ATOM   2953  C  CB    . ALA A 1 518 ? 98.006  100.275 104.899 1.00 48.22  ? 510 ALA A CB    1 
ATOM   2954  N  N     . GLN A 1 519 ? 100.184 97.991  105.081 1.00 53.57  ? 511 GLN A N     1 
ATOM   2955  C  CA    . GLN A 1 519 ? 100.578 96.596  104.906 1.00 53.58  ? 511 GLN A CA    1 
ATOM   2956  C  C     . GLN A 1 519 ? 101.205 96.032  106.176 1.00 55.41  ? 511 GLN A C     1 
ATOM   2957  O  O     . GLN A 1 519 ? 100.987 94.863  106.517 1.00 55.06  ? 511 GLN A O     1 
ATOM   2958  C  CB    . GLN A 1 519 ? 101.532 96.464  103.722 1.00 55.07  ? 511 GLN A CB    1 
ATOM   2959  C  CG    . GLN A 1 519 ? 100.915 96.873  102.396 1.00 65.58  ? 511 GLN A CG    1 
ATOM   2960  C  CD    . GLN A 1 519 ? 99.652  96.097  102.075 1.00 64.69  ? 511 GLN A CD    1 
ATOM   2961  O  OE1   . GLN A 1 519 ? 99.530  94.918  102.410 1.00 66.69  ? 511 GLN A OE1   1 
ATOM   2962  N  NE2   . GLN A 1 519 ? 98.702  96.757  101.424 1.00 52.29  ? 511 GLN A NE2   1 
ATOM   2963  N  N     . GLN A 1 520 ? 101.986 96.847  106.890 1.00 54.35  ? 512 GLN A N     1 
ATOM   2964  C  CA    . GLN A 1 520 ? 102.535 96.405  108.169 1.00 52.79  ? 512 GLN A CA    1 
ATOM   2965  C  C     . GLN A 1 520 ? 101.424 96.084  109.160 1.00 50.69  ? 512 GLN A C     1 
ATOM   2966  O  O     . GLN A 1 520 ? 101.483 95.070  109.864 1.00 50.43  ? 512 GLN A O     1 
ATOM   2967  C  CB    . GLN A 1 520 ? 103.464 97.473  108.744 1.00 56.10  ? 512 GLN A CB    1 
ATOM   2968  C  CG    . GLN A 1 520 ? 104.696 97.750  107.909 1.00 60.54  ? 512 GLN A CG    1 
ATOM   2969  C  CD    . GLN A 1 520 ? 105.471 98.952  108.408 1.00 64.88  ? 512 GLN A CD    1 
ATOM   2970  O  OE1   . GLN A 1 520 ? 105.240 99.436  109.516 1.00 65.58  ? 512 GLN A OE1   1 
ATOM   2971  N  NE2   . GLN A 1 520 ? 106.393 99.444  107.589 1.00 64.19  ? 512 GLN A NE2   1 
ATOM   2972  N  N     . PHE A 1 521 ? 100.401 96.939  109.227 1.00 49.93  ? 513 PHE A N     1 
ATOM   2973  C  CA    . PHE A 1 521 ? 99.270  96.677  110.109 1.00 48.40  ? 513 PHE A CA    1 
ATOM   2974  C  C     . PHE A 1 521 ? 98.509  95.432  109.680 1.00 46.53  ? 513 PHE A C     1 
ATOM   2975  O  O     . PHE A 1 521 ? 98.031  94.672  110.526 1.00 50.23  ? 513 PHE A O     1 
ATOM   2976  C  CB    . PHE A 1 521 ? 98.334  97.883  110.149 1.00 43.08  ? 513 PHE A CB    1 
ATOM   2977  C  CG    . PHE A 1 521 ? 96.968  97.561  110.677 1.00 41.65  ? 513 PHE A CG    1 
ATOM   2978  C  CD1   . PHE A 1 521 ? 96.758  97.398  112.034 1.00 43.76  ? 513 PHE A CD1   1 
ATOM   2979  C  CD2   . PHE A 1 521 ? 95.896  97.406  109.816 1.00 40.08  ? 513 PHE A CD2   1 
ATOM   2980  C  CE1   . PHE A 1 521 ? 95.507  97.092  112.521 1.00 41.46  ? 513 PHE A CE1   1 
ATOM   2981  C  CE2   . PHE A 1 521 ? 94.644  97.099  110.299 1.00 37.98  ? 513 PHE A CE2   1 
ATOM   2982  C  CZ    . PHE A 1 521 ? 94.450  96.943  111.652 1.00 38.47  ? 513 PHE A CZ    1 
ATOM   2983  N  N     . LEU A 1 522 ? 98.361  95.220  108.371 1.00 46.05  ? 514 LEU A N     1 
ATOM   2984  C  CA    . LEU A 1 522 ? 97.693  94.015  107.893 1.00 47.40  ? 514 LEU A CA    1 
ATOM   2985  C  C     . LEU A 1 522 ? 98.453  92.764  108.313 1.00 53.08  ? 514 LEU A C     1 
ATOM   2986  O  O     . LEU A 1 522 ? 97.850  91.780  108.762 1.00 55.76  ? 514 LEU A O     1 
ATOM   2987  C  CB    . LEU A 1 522 ? 97.542  94.072  106.373 1.00 46.06  ? 514 LEU A CB    1 
ATOM   2988  C  CG    . LEU A 1 522 ? 97.079  92.798  105.667 1.00 47.18  ? 514 LEU A CG    1 
ATOM   2989  C  CD1   . LEU A 1 522 ? 95.739  92.334  106.203 1.00 46.40  ? 514 LEU A CD1   1 
ATOM   2990  C  CD2   . LEU A 1 522 ? 97.004  93.028  104.170 1.00 49.07  ? 514 LEU A CD2   1 
ATOM   2991  N  N     . ARG A 1 523 ? 99.781  92.788  108.184 1.00 54.43  ? 515 ARG A N     1 
ATOM   2992  C  CA    . ARG A 1 523 ? 100.584 91.650  108.619 1.00 50.87  ? 515 ARG A CA    1 
ATOM   2993  C  C     . ARG A 1 523 ? 100.483 91.446  110.126 1.00 53.85  ? 515 ARG A C     1 
ATOM   2994  O  O     . ARG A 1 523 ? 100.388 90.308  110.600 1.00 58.66  ? 515 ARG A O     1 
ATOM   2995  C  CB    . ARG A 1 523 ? 102.041 91.838  108.198 1.00 51.24  ? 515 ARG A CB    1 
ATOM   2996  C  CG    . ARG A 1 523 ? 102.264 91.777  106.695 1.00 58.25  ? 515 ARG A CG    1 
ATOM   2997  C  CD    . ARG A 1 523 ? 103.738 91.628  106.360 1.00 62.44  ? 515 ARG A CD    1 
ATOM   2998  N  NE    . ARG A 1 523 ? 104.528 92.765  106.816 1.00 64.94  ? 515 ARG A NE    1 
ATOM   2999  C  CZ    . ARG A 1 523 ? 104.866 93.796  106.054 1.00 65.01  ? 515 ARG A CZ    1 
ATOM   3000  N  NH1   . ARG A 1 523 ? 104.495 93.869  104.787 1.00 57.72  ? 515 ARG A NH1   1 
ATOM   3001  N  NH2   . ARG A 1 523 ? 105.596 94.776  106.577 1.00 65.13  ? 515 ARG A NH2   1 
ATOM   3002  N  N     . TYR A 1 524 ? 100.503 92.538  110.895 1.00 49.50  ? 516 TYR A N     1 
ATOM   3003  C  CA    . TYR A 1 524 ? 100.379 92.425  112.345 1.00 48.06  ? 516 TYR A CA    1 
ATOM   3004  C  C     . TYR A 1 524 ? 99.031  91.837  112.743 1.00 49.79  ? 516 TYR A C     1 
ATOM   3005  O  O     . TYR A 1 524 ? 98.956  90.985  113.636 1.00 54.14  ? 516 TYR A O     1 
ATOM   3006  C  CB    . TYR A 1 524 ? 100.577 93.793  112.999 1.00 49.93  ? 516 TYR A CB    1 
ATOM   3007  C  CG    . TYR A 1 524 ? 100.248 93.819  114.476 1.00 53.95  ? 516 TYR A CG    1 
ATOM   3008  C  CD1   . TYR A 1 524 ? 101.175 93.406  115.421 1.00 55.15  ? 516 TYR A CD1   1 
ATOM   3009  C  CD2   . TYR A 1 524 ? 99.011  94.261  114.926 1.00 50.71  ? 516 TYR A CD2   1 
ATOM   3010  C  CE1   . TYR A 1 524 ? 100.879 93.426  116.769 1.00 52.19  ? 516 TYR A CE1   1 
ATOM   3011  C  CE2   . TYR A 1 524 ? 98.707  94.284  116.271 1.00 52.64  ? 516 TYR A CE2   1 
ATOM   3012  C  CZ    . TYR A 1 524 ? 99.645  93.866  117.188 1.00 54.37  ? 516 TYR A CZ    1 
ATOM   3013  O  OH    . TYR A 1 524 ? 99.348  93.888  118.531 1.00 57.60  ? 516 TYR A OH    1 
ATOM   3014  N  N     . ALA A 1 525 ? 97.955  92.285  112.097 1.00 49.01  ? 517 ALA A N     1 
ATOM   3015  C  CA    . ALA A 1 525 ? 96.622  91.819  112.457 1.00 50.42  ? 517 ALA A CA    1 
ATOM   3016  C  C     . ALA A 1 525 ? 96.409  90.370  112.047 1.00 53.02  ? 517 ALA A C     1 
ATOM   3017  O  O     . ALA A 1 525 ? 95.781  89.599  112.782 1.00 56.70  ? 517 ALA A O     1 
ATOM   3018  C  CB    . ALA A 1 525 ? 95.564  92.718  111.821 1.00 48.71  ? 517 ALA A CB    1 
ATOM   3019  N  N     . GLN A 1 526 ? 96.915  89.979  110.875 1.00 50.85  ? 518 GLN A N     1 
ATOM   3020  C  CA    . GLN A 1 526 ? 96.776  88.588  110.460 1.00 53.35  ? 518 GLN A CA    1 
ATOM   3021  C  C     . GLN A 1 526 ? 97.666  87.665  111.284 1.00 58.87  ? 518 GLN A C     1 
ATOM   3022  O  O     . GLN A 1 526 ? 97.362  86.476  111.423 1.00 63.10  ? 518 GLN A O     1 
ATOM   3023  C  CB    . GLN A 1 526 ? 97.088  88.449  108.971 1.00 55.89  ? 518 GLN A CB    1 
ATOM   3024  C  CG    . GLN A 1 526 ? 96.032  89.063  108.069 1.00 58.15  ? 518 GLN A CG    1 
ATOM   3025  C  CD    . GLN A 1 526 ? 96.324  88.853  106.598 1.00 56.36  ? 518 GLN A CD    1 
ATOM   3026  O  OE1   . GLN A 1 526 ? 97.453  88.549  106.214 1.00 60.84  ? 518 GLN A OE1   1 
ATOM   3027  N  NE2   . GLN A 1 526 ? 95.304  89.013  105.764 1.00 48.97  ? 518 GLN A NE2   1 
ATOM   3028  N  N     . GLY A 1 527 ? 98.754  88.189  111.836 1.00 57.55  ? 519 GLY A N     1 
ATOM   3029  C  CA    . GLY A 1 527 ? 99.657  87.427  112.669 1.00 56.36  ? 519 GLY A CA    1 
ATOM   3030  C  C     . GLY A 1 527 ? 99.349  87.450  114.150 1.00 59.46  ? 519 GLY A C     1 
ATOM   3031  O  O     . GLY A 1 527 ? 100.136 86.918  114.939 1.00 66.42  ? 519 GLY A O     1 
ATOM   3032  N  N     . SER A 1 528 ? 98.234  88.050  114.556 1.00 58.01  ? 520 SER A N     1 
ATOM   3033  C  CA    . SER A 1 528 ? 97.851  88.147  115.958 1.00 55.87  ? 520 SER A CA    1 
ATOM   3034  C  C     . SER A 1 528 ? 96.597  87.320  116.200 1.00 59.11  ? 520 SER A C     1 
ATOM   3035  O  O     . SER A 1 528 ? 95.594  87.487  115.499 1.00 60.01  ? 520 SER A O     1 
ATOM   3036  C  CB    . SER A 1 528 ? 97.610  89.603  116.359 1.00 55.79  ? 520 SER A CB    1 
ATOM   3037  O  OG    . SER A 1 528 ? 97.134  89.690  117.690 1.00 65.06  ? 520 SER A OG    1 
ATOM   3038  N  N     . GLU A 1 529 ? 96.658  86.428  117.191 1.00 58.25  ? 521 GLU A N     1 
ATOM   3039  C  CA    . GLU A 1 529 ? 95.504  85.590  117.502 1.00 61.11  ? 521 GLU A CA    1 
ATOM   3040  C  C     . GLU A 1 529 ? 94.346  86.417  118.046 1.00 60.98  ? 521 GLU A C     1 
ATOM   3041  O  O     . GLU A 1 529 ? 93.181  86.150  117.727 1.00 61.68  ? 521 GLU A O     1 
ATOM   3042  C  CB    . GLU A 1 529 ? 95.899  84.501  118.497 1.00 65.89  ? 521 GLU A CB    1 
ATOM   3043  C  CG    . GLU A 1 529 ? 94.759  83.568  118.877 1.00 72.28  ? 521 GLU A CG    1 
ATOM   3044  C  CD    . GLU A 1 529 ? 95.184  82.495  119.861 1.00 83.56  ? 521 GLU A CD    1 
ATOM   3045  O  OE1   . GLU A 1 529 ? 96.392  82.413  120.168 1.00 85.86  ? 521 GLU A OE1   1 
ATOM   3046  O  OE2   . GLU A 1 529 ? 94.310  81.735  120.327 1.00 86.86  ? 521 GLU A OE2   1 
ATOM   3047  N  N     . VAL A 1 530 ? 94.647  87.423  118.870 1.00 58.47  ? 522 VAL A N     1 
ATOM   3048  C  CA    . VAL A 1 530 ? 93.595  88.226  119.491 1.00 56.55  ? 522 VAL A CA    1 
ATOM   3049  C  C     . VAL A 1 530 ? 92.786  88.960  118.429 1.00 57.54  ? 522 VAL A C     1 
ATOM   3050  O  O     . VAL A 1 530 ? 91.550  88.958  118.453 1.00 59.02  ? 522 VAL A O     1 
ATOM   3051  C  CB    . VAL A 1 530 ? 94.201  89.205  120.512 1.00 55.64  ? 522 VAL A CB    1 
ATOM   3052  C  CG1   . VAL A 1 530 ? 93.119  90.090  121.103 1.00 55.75  ? 522 VAL A CG1   1 
ATOM   3053  C  CG2   . VAL A 1 530 ? 94.932  88.445  121.605 1.00 60.73  ? 522 VAL A CG2   1 
ATOM   3054  N  N     . LEU A 1 531 ? 93.472  89.597  117.478 1.00 55.74  ? 523 LEU A N     1 
ATOM   3055  C  CA    . LEU A 1 531 ? 92.770  90.367  116.456 1.00 53.43  ? 523 LEU A CA    1 
ATOM   3056  C  C     . LEU A 1 531 ? 92.026  89.458  115.486 1.00 54.92  ? 523 LEU A C     1 
ATOM   3057  O  O     . LEU A 1 531 ? 90.938  89.805  115.014 1.00 53.74  ? 523 LEU A O     1 
ATOM   3058  C  CB    . LEU A 1 531 ? 93.753  91.265  115.709 1.00 54.45  ? 523 LEU A CB    1 
ATOM   3059  C  CG    . LEU A 1 531 ? 94.526  92.262  116.572 1.00 50.61  ? 523 LEU A CG    1 
ATOM   3060  C  CD1   . LEU A 1 531 ? 95.329  93.210  115.702 1.00 53.73  ? 523 LEU A CD1   1 
ATOM   3061  C  CD2   . LEU A 1 531 ? 93.581  93.030  117.476 1.00 50.53  ? 523 LEU A CD2   1 
ATOM   3062  N  N     . MET A 1 532 ? 92.595  88.293  115.170 1.00 54.76  ? 524 MET A N     1 
ATOM   3063  C  CA    . MET A 1 532 ? 91.930  87.374  114.256 1.00 54.17  ? 524 MET A CA    1 
ATOM   3064  C  C     . MET A 1 532 ? 90.754  86.659  114.904 1.00 58.06  ? 524 MET A C     1 
ATOM   3065  O  O     . MET A 1 532 ? 89.873  86.171  114.189 1.00 60.47  ? 524 MET A O     1 
ATOM   3066  C  CB    . MET A 1 532 ? 92.926  86.346  113.717 1.00 57.12  ? 524 MET A CB    1 
ATOM   3067  C  CG    . MET A 1 532 ? 93.952  86.923  112.759 1.00 64.50  ? 524 MET A CG    1 
ATOM   3068  S  SD    . MET A 1 532 ? 93.203  87.733  111.333 1.00 72.74  ? 524 MET A SD    1 
ATOM   3069  C  CE    . MET A 1 532 ? 92.291  86.373  110.608 1.00 64.01  ? 524 MET A CE    1 
ATOM   3070  N  N     . SER A 1 533 ? 90.719  86.582  116.234 1.00 56.35  ? 525 SER A N     1 
ATOM   3071  C  CA    . SER A 1 533 ? 89.597  85.956  116.919 1.00 55.72  ? 525 SER A CA    1 
ATOM   3072  C  C     . SER A 1 533 ? 88.389  86.874  117.041 1.00 57.96  ? 525 SER A C     1 
ATOM   3073  O  O     . SER A 1 533 ? 87.297  86.392  117.363 1.00 57.76  ? 525 SER A O     1 
ATOM   3074  C  CB    . SER A 1 533 ? 90.030  85.492  118.311 1.00 61.61  ? 525 SER A CB    1 
ATOM   3075  O  OG    . SER A 1 533 ? 90.568  86.569  119.057 1.00 64.50  ? 525 SER A OG    1 
ATOM   3076  N  N     . ARG A 1 534 ? 88.554  88.169  116.793 1.00 60.08  ? 526 ARG A N     1 
ATOM   3077  C  CA    . ARG A 1 534 ? 87.477  89.145  116.889 1.00 57.03  ? 526 ARG A CA    1 
ATOM   3078  C  C     . ARG A 1 534 ? 87.139  89.662  115.499 1.00 55.08  ? 526 ARG A C     1 
ATOM   3079  O  O     . ARG A 1 534 ? 88.020  90.149  114.782 1.00 54.91  ? 526 ARG A O     1 
ATOM   3080  C  CB    . ARG A 1 534 ? 87.874  90.308  117.799 1.00 55.10  ? 526 ARG A CB    1 
ATOM   3081  C  CG    . ARG A 1 534 ? 88.125  89.914  119.242 1.00 53.93  ? 526 ARG A CG    1 
ATOM   3082  C  CD    . ARG A 1 534 ? 86.828  89.832  120.026 1.00 52.51  ? 526 ARG A CD    1 
ATOM   3083  N  NE    . ARG A 1 534 ? 86.147  91.120  120.069 1.00 47.85  ? 526 ARG A NE    1 
ATOM   3084  C  CZ    . ARG A 1 534 ? 86.456  92.102  120.905 1.00 51.14  ? 526 ARG A CZ    1 
ATOM   3085  N  NH1   . ARG A 1 534 ? 87.437  91.979  121.783 1.00 48.73  ? 526 ARG A NH1   1 
ATOM   3086  N  NH2   . ARG A 1 534 ? 85.767  93.237  120.854 1.00 50.13  ? 526 ARG A NH2   1 
ATOM   3087  N  N     . HIS A 1 535 ? 85.864  89.562  115.123 1.00 54.42  ? 527 HIS A N     1 
ATOM   3088  C  CA    . HIS A 1 535 ? 85.403  90.037  113.829 1.00 54.57  ? 527 HIS A CA    1 
ATOM   3089  C  C     . HIS A 1 535 ? 84.621  91.339  113.904 1.00 51.38  ? 527 HIS A C     1 
ATOM   3090  O  O     . HIS A 1 535 ? 84.473  92.011  112.877 1.00 50.68  ? 527 HIS A O     1 
ATOM   3091  C  CB    . HIS A 1 535 ? 84.533  88.971  113.148 1.00 56.46  ? 527 HIS A CB    1 
ATOM   3092  C  CG    . HIS A 1 535 ? 85.232  87.663  112.944 1.00 62.75  ? 527 HIS A CG    1 
ATOM   3093  N  ND1   . HIS A 1 535 ? 86.245  87.497  112.025 1.00 65.19  ? 527 HIS A ND1   1 
ATOM   3094  C  CD2   . HIS A 1 535 ? 85.061  86.459  113.539 1.00 66.81  ? 527 HIS A CD2   1 
ATOM   3095  C  CE1   . HIS A 1 535 ? 86.670  86.247  112.064 1.00 70.11  ? 527 HIS A CE1   1 
ATOM   3096  N  NE2   . HIS A 1 535 ? 85.968  85.596  112.974 1.00 73.23  ? 527 HIS A NE2   1 
ATOM   3097  N  N     . ASN A 1 536 ? 84.127  91.721  115.083 1.00 49.47  ? 528 ASN A N     1 
ATOM   3098  C  CA    . ASN A 1 536 ? 83.305  92.915  115.235 1.00 47.01  ? 528 ASN A CA    1 
ATOM   3099  C  C     . ASN A 1 536 ? 84.131  94.172  115.474 1.00 40.50  ? 528 ASN A C     1 
ATOM   3100  O  O     . ASN A 1 536 ? 83.635  95.131  116.078 1.00 40.92  ? 528 ASN A O     1 
ATOM   3101  C  CB    . ASN A 1 536 ? 82.292  92.716  116.363 1.00 47.72  ? 528 ASN A CB    1 
ATOM   3102  C  CG    . ASN A 1 536 ? 82.948  92.375  117.683 1.00 48.71  ? 528 ASN A CG    1 
ATOM   3103  O  OD1   . ASN A 1 536 ? 84.113  91.984  117.727 1.00 51.44  ? 528 ASN A OD1   1 
ATOM   3104  N  ND2   . ASN A 1 536 ? 82.197  92.512  118.769 1.00 50.51  ? 528 ASN A ND2   1 
ATOM   3105  N  N     . VAL A 1 537 ? 85.378  94.194  115.016 1.00 38.73  ? 529 VAL A N     1 
ATOM   3106  C  CA    . VAL A 1 537 ? 86.236  95.368  115.109 1.00 34.60  ? 529 VAL A CA    1 
ATOM   3107  C  C     . VAL A 1 537 ? 86.355  95.965  113.716 1.00 33.47  ? 529 VAL A C     1 
ATOM   3108  O  O     . VAL A 1 537 ? 86.865  95.315  112.796 1.00 37.85  ? 529 VAL A O     1 
ATOM   3109  C  CB    . VAL A 1 537 ? 87.617  95.022  115.681 1.00 34.72  ? 529 VAL A CB    1 
ATOM   3110  C  CG1   . VAL A 1 537 ? 88.432  96.287  115.891 1.00 33.52  ? 529 VAL A CG1   1 
ATOM   3111  C  CG2   . VAL A 1 537 ? 87.472  94.252  116.980 1.00 44.46  ? 529 VAL A CG2   1 
ATOM   3112  N  N     . GLY A 1 538 ? 85.884  97.199  113.560 1.00 28.04  ? 530 GLY A N     1 
ATOM   3113  C  CA    . GLY A 1 538 ? 85.930  97.866  112.276 1.00 28.96  ? 530 GLY A CA    1 
ATOM   3114  C  C     . GLY A 1 538 ? 87.189  98.683  112.085 1.00 27.54  ? 530 GLY A C     1 
ATOM   3115  O  O     . GLY A 1 538 ? 87.413  99.666  112.796 1.00 30.69  ? 530 GLY A O     1 
ATOM   3116  N  N     . TYR A 1 539 ? 88.020  98.285  111.129 1.00 28.07  ? 531 TYR A N     1 
ATOM   3117  C  CA    . TYR A 1 539 ? 89.270  98.975  110.835 1.00 26.94  ? 531 TYR A CA    1 
ATOM   3118  C  C     . TYR A 1 539 ? 89.058  99.845  109.603 1.00 29.43  ? 531 TYR A C     1 
ATOM   3119  O  O     . TYR A 1 539 ? 88.902  99.331  108.492 1.00 35.05  ? 531 TYR A O     1 
ATOM   3120  C  CB    . TYR A 1 539 ? 90.404  97.979  110.611 1.00 28.77  ? 531 TYR A CB    1 
ATOM   3121  C  CG    . TYR A 1 539 ? 90.564  96.958  111.714 1.00 30.10  ? 531 TYR A CG    1 
ATOM   3122  C  CD1   . TYR A 1 539 ? 91.327  97.236  112.838 1.00 31.63  ? 531 TYR A CD1   1 
ATOM   3123  C  CD2   . TYR A 1 539 ? 89.958  95.714  111.626 1.00 29.55  ? 531 TYR A CD2   1 
ATOM   3124  C  CE1   . TYR A 1 539 ? 91.480  96.305  113.844 1.00 34.58  ? 531 TYR A CE1   1 
ATOM   3125  C  CE2   . TYR A 1 539 ? 90.104  94.777  112.626 1.00 29.83  ? 531 TYR A CE2   1 
ATOM   3126  C  CZ    . TYR A 1 539 ? 90.867  95.077  113.732 1.00 35.38  ? 531 TYR A CZ    1 
ATOM   3127  O  OH    . TYR A 1 539 ? 91.014  94.145  114.732 1.00 40.23  ? 531 TYR A OH    1 
ATOM   3128  N  N     . HIS A 1 540 ? 89.056  101.157 109.797 1.00 26.51  ? 532 HIS A N     1 
ATOM   3129  C  CA    . HIS A 1 540 ? 88.895  102.115 108.711 1.00 25.35  ? 532 HIS A CA    1 
ATOM   3130  C  C     . HIS A 1 540 ? 90.214  102.857 108.555 1.00 27.40  ? 532 HIS A C     1 
ATOM   3131  O  O     . HIS A 1 540 ? 90.594  103.647 109.423 1.00 32.88  ? 532 HIS A O     1 
ATOM   3132  C  CB    . HIS A 1 540 ? 87.745  103.078 108.995 1.00 27.75  ? 532 HIS A CB    1 
ATOM   3133  C  CG    . HIS A 1 540 ? 86.504  102.403 109.489 1.00 30.18  ? 532 HIS A CG    1 
ATOM   3134  N  ND1   . HIS A 1 540 ? 85.806  101.485 108.736 1.00 31.55  ? 532 HIS A ND1   1 
ATOM   3135  C  CD2   . HIS A 1 540 ? 85.840  102.509 110.664 1.00 31.50  ? 532 HIS A CD2   1 
ATOM   3136  C  CE1   . HIS A 1 540 ? 84.764  101.055 109.425 1.00 32.75  ? 532 HIS A CE1   1 
ATOM   3137  N  NE2   . HIS A 1 540 ? 84.762  101.660 110.598 1.00 30.07  ? 532 HIS A NE2   1 
ATOM   3138  N  N     . ILE A 1 541 ? 90.909  102.604 107.454 1.00 30.66  ? 533 ILE A N     1 
ATOM   3139  C  CA    . ILE A 1 541 ? 92.228  103.180 107.229 1.00 34.37  ? 533 ILE A CA    1 
ATOM   3140  C  C     . ILE A 1 541 ? 92.073  104.473 106.443 1.00 32.74  ? 533 ILE A C     1 
ATOM   3141  O  O     . ILE A 1 541 ? 91.500  104.484 105.349 1.00 35.85  ? 533 ILE A O     1 
ATOM   3142  C  CB    . ILE A 1 541 ? 93.151  102.195 106.498 1.00 32.41  ? 533 ILE A CB    1 
ATOM   3143  C  CG1   . ILE A 1 541 ? 93.507  101.029 107.420 1.00 33.17  ? 533 ILE A CG1   1 
ATOM   3144  C  CG2   . ILE A 1 541 ? 94.404  102.904 106.012 1.00 35.06  ? 533 ILE A CG2   1 
ATOM   3145  C  CD1   . ILE A 1 541 ? 94.680  100.208 106.946 1.00 42.60  ? 533 ILE A CD1   1 
ATOM   3146  N  N     . VAL A 1 542 ? 92.581  105.562 107.006 1.00 29.54  ? 534 VAL A N     1 
ATOM   3147  C  CA    . VAL A 1 542 ? 92.613  106.861 106.350 1.00 34.61  ? 534 VAL A CA    1 
ATOM   3148  C  C     . VAL A 1 542 ? 94.066  107.143 106.001 1.00 38.83  ? 534 VAL A C     1 
ATOM   3149  O  O     . VAL A 1 542 ? 94.895  107.368 106.892 1.00 38.82  ? 534 VAL A O     1 
ATOM   3150  C  CB    . VAL A 1 542 ? 92.023  107.961 107.241 1.00 35.07  ? 534 VAL A CB    1 
ATOM   3151  C  CG1   . VAL A 1 542 ? 92.200  109.315 106.596 1.00 44.02  ? 534 VAL A CG1   1 
ATOM   3152  C  CG2   . VAL A 1 542 ? 90.554  107.684 107.515 1.00 34.16  ? 534 VAL A CG2   1 
ATOM   3153  N  N     . TYR A 1 543 ? 94.379  107.135 104.710 1.00 42.76  ? 535 TYR A N     1 
ATOM   3154  C  CA    . TYR A 1 543 ? 95.768  107.191 104.277 1.00 43.14  ? 535 TYR A CA    1 
ATOM   3155  C  C     . TYR A 1 543 ? 96.375  108.564 104.542 1.00 47.30  ? 535 TYR A C     1 
ATOM   3156  O  O     . TYR A 1 543 ? 95.699  109.593 104.481 1.00 50.87  ? 535 TYR A O     1 
ATOM   3157  C  CB    . TYR A 1 543 ? 95.876  106.828 102.798 1.00 40.88  ? 535 TYR A CB    1 
ATOM   3158  C  CG    . TYR A 1 543 ? 95.547  105.379 102.529 1.00 41.29  ? 535 TYR A CG    1 
ATOM   3159  C  CD1   . TYR A 1 543 ? 96.512  104.393 102.670 1.00 44.40  ? 535 TYR A CD1   1 
ATOM   3160  C  CD2   . TYR A 1 543 ? 94.270  104.995 102.149 1.00 39.97  ? 535 TYR A CD2   1 
ATOM   3161  C  CE1   . TYR A 1 543 ? 96.216  103.066 102.432 1.00 47.82  ? 535 TYR A CE1   1 
ATOM   3162  C  CE2   . TYR A 1 543 ? 93.964  103.671 101.909 1.00 41.85  ? 535 TYR A CE2   1 
ATOM   3163  C  CZ    . TYR A 1 543 ? 94.941  102.711 102.052 1.00 47.10  ? 535 TYR A CZ    1 
ATOM   3164  O  OH    . TYR A 1 543 ? 94.642  101.391 101.813 1.00 47.32  ? 535 TYR A OH    1 
ATOM   3165  N  N     . LYS A 1 544 ? 97.671  108.562 104.842 1.00 48.40  ? 536 LYS A N     1 
ATOM   3166  C  CA    . LYS A 1 544 ? 98.349  109.772 105.282 1.00 50.35  ? 536 LYS A CA    1 
ATOM   3167  C  C     . LYS A 1 544 ? 98.426  110.807 104.168 1.00 54.40  ? 536 LYS A C     1 
ATOM   3168  O  O     . LYS A 1 544 ? 98.688  110.483 103.007 1.00 56.24  ? 536 LYS A O     1 
ATOM   3169  C  CB    . LYS A 1 544 ? 99.757  109.443 105.778 1.00 51.72  ? 536 LYS A CB    1 
ATOM   3170  C  CG    . LYS A 1 544 ? 99.795  108.644 107.067 1.00 50.38  ? 536 LYS A CG    1 
ATOM   3171  C  CD    . LYS A 1 544 ? 101.213 108.538 107.600 1.00 52.99  ? 536 LYS A CD    1 
ATOM   3172  C  CE    . LYS A 1 544 ? 101.245 107.848 108.952 1.00 58.32  ? 536 LYS A CE    1 
ATOM   3173  N  NZ    . LYS A 1 544 ? 102.628 107.754 109.493 1.00 66.51  ? 536 LYS A NZ    1 
ATOM   3174  N  N     . GLU A 1 545 ? 98.197  112.063 104.539 1.00 58.16  ? 537 GLU A N     1 
ATOM   3175  C  CA    . GLU A 1 545 ? 98.334  113.191 103.632 1.00 60.21  ? 537 GLU A CA    1 
ATOM   3176  C  C     . GLU A 1 545 ? 98.505  114.446 104.472 1.00 64.82  ? 537 GLU A C     1 
ATOM   3177  O  O     . GLU A 1 545 ? 97.887  114.574 105.532 1.00 65.50  ? 537 GLU A O     1 
ATOM   3178  C  CB    . GLU A 1 545 ? 97.121  113.320 102.703 1.00 63.92  ? 537 GLU A CB    1 
ATOM   3179  C  CG    . GLU A 1 545 ? 97.220  114.462 101.706 1.00 71.70  ? 537 GLU A CG    1 
ATOM   3180  C  CD    . GLU A 1 545 ? 96.042  114.512 100.757 1.00 78.15  ? 537 GLU A CD    1 
ATOM   3181  O  OE1   . GLU A 1 545 ? 95.209  113.582 100.792 1.00 79.30  ? 537 GLU A OE1   1 
ATOM   3182  O  OE2   . GLU A 1 545 ? 95.948  115.481 99.975  1.00 74.96  ? 537 GLU A OE2   1 
ATOM   3183  N  N     . GLY A 1 546 ? 99.342  115.359 104.002 1.00 66.68  ? 538 GLY A N     1 
ATOM   3184  C  CA    . GLY A 1 546 ? 99.601  116.573 104.741 1.00 71.73  ? 538 GLY A CA    1 
ATOM   3185  C  C     . GLY A 1 546 ? 100.643 116.377 105.825 1.00 74.67  ? 538 GLY A C     1 
ATOM   3186  O  O     . GLY A 1 546 ? 101.338 115.360 105.900 1.00 70.48  ? 538 GLY A O     1 
ATOM   3187  N  N     . GLN A 1 547 ? 100.743 117.389 106.689 1.00 77.64  ? 539 GLN A N     1 
ATOM   3188  C  CA    . GLN A 1 547 ? 101.750 117.411 107.738 1.00 75.32  ? 539 GLN A CA    1 
ATOM   3189  C  C     . GLN A 1 547 ? 101.201 117.159 109.134 1.00 73.69  ? 539 GLN A C     1 
ATOM   3190  O  O     . GLN A 1 547 ? 101.973 116.780 110.020 1.00 77.06  ? 539 GLN A O     1 
ATOM   3191  C  CB    . GLN A 1 547 ? 102.485 118.759 107.741 1.00 76.98  ? 539 GLN A CB    1 
ATOM   3192  C  CG    . GLN A 1 547 ? 103.132 119.118 106.418 1.00 81.26  ? 539 GLN A CG    1 
ATOM   3193  C  CD    . GLN A 1 547 ? 103.824 120.465 106.457 1.00 86.92  ? 539 GLN A CD    1 
ATOM   3194  O  OE1   . GLN A 1 547 ? 103.757 121.179 107.457 1.00 86.78  ? 539 GLN A OE1   1 
ATOM   3195  N  NE2   . GLN A 1 547 ? 104.494 120.819 105.368 1.00 88.96  ? 539 GLN A NE2   1 
ATOM   3196  N  N     . PHE A 1 548 ? 99.907  117.355 109.354 1.00 72.21  ? 540 PHE A N     1 
ATOM   3197  C  CA    . PHE A 1 548 ? 99.324  117.292 110.685 1.00 70.54  ? 540 PHE A CA    1 
ATOM   3198  C  C     . PHE A 1 548 ? 98.449  116.056 110.835 1.00 67.89  ? 540 PHE A C     1 
ATOM   3199  O  O     . PHE A 1 548 ? 98.133  115.359 109.868 1.00 67.38  ? 540 PHE A O     1 
ATOM   3200  C  CB    . PHE A 1 548 ? 98.515  118.558 110.977 1.00 72.34  ? 540 PHE A CB    1 
ATOM   3201  C  CG    . PHE A 1 548 ? 99.277  119.822 110.739 1.00 77.45  ? 540 PHE A CG    1 
ATOM   3202  C  CD1   . PHE A 1 548 ? 100.140 120.314 111.699 1.00 82.49  ? 540 PHE A CD1   1 
ATOM   3203  C  CD2   . PHE A 1 548 ? 99.139  120.513 109.551 1.00 84.82  ? 540 PHE A CD2   1 
ATOM   3204  C  CE1   . PHE A 1 548 ? 100.847 121.476 111.479 1.00 88.93  ? 540 PHE A CE1   1 
ATOM   3205  C  CE2   . PHE A 1 548 ? 99.843  121.675 109.326 1.00 90.45  ? 540 PHE A CE2   1 
ATOM   3206  C  CZ    . PHE A 1 548 ? 100.699 122.158 110.292 1.00 91.74  ? 540 PHE A CZ    1 
ATOM   3207  N  N     . TYR A 1 549 ? 98.058  115.794 112.081 1.00 64.04  ? 541 TYR A N     1 
ATOM   3208  C  CA    . TYR A 1 549 ? 97.268  114.617 112.408 1.00 60.30  ? 541 TYR A CA    1 
ATOM   3209  C  C     . TYR A 1 549 ? 95.791  114.985 112.385 1.00 60.97  ? 541 TYR A C     1 
ATOM   3210  O  O     . TYR A 1 549 ? 95.351  115.785 113.224 1.00 61.43  ? 541 TYR A O     1 
ATOM   3211  C  CB    . TYR A 1 549 ? 97.663  114.077 113.774 1.00 59.52  ? 541 TYR A CB    1 
ATOM   3212  C  CG    . TYR A 1 549 ? 96.995  112.776 114.142 1.00 53.58  ? 541 TYR A CG    1 
ATOM   3213  C  CD1   . TYR A 1 549 ? 97.435  111.575 113.609 1.00 53.68  ? 541 TYR A CD1   1 
ATOM   3214  C  CD2   . TYR A 1 549 ? 95.930  112.748 115.030 1.00 50.89  ? 541 TYR A CD2   1 
ATOM   3215  C  CE1   . TYR A 1 549 ? 96.829  110.384 113.942 1.00 52.57  ? 541 TYR A CE1   1 
ATOM   3216  C  CE2   . TYR A 1 549 ? 95.318  111.561 115.370 1.00 46.64  ? 541 TYR A CE2   1 
ATOM   3217  C  CZ    . TYR A 1 549 ? 95.772  110.383 114.824 1.00 46.15  ? 541 TYR A CZ    1 
ATOM   3218  O  OH    . TYR A 1 549 ? 95.166  109.197 115.159 1.00 44.71  ? 541 TYR A OH    1 
ATOM   3219  N  N     . PRO A 1 550 ? 94.996  114.439 111.464 1.00 59.42  ? 542 PRO A N     1 
ATOM   3220  C  CA    . PRO A 1 550 ? 93.556  114.762 111.398 1.00 60.50  ? 542 PRO A CA    1 
ATOM   3221  C  C     . PRO A 1 550 ? 92.745  113.980 112.428 1.00 54.89  ? 542 PRO A C     1 
ATOM   3222  O  O     . PRO A 1 550 ? 92.028  113.025 112.134 1.00 54.90  ? 542 PRO A O     1 
ATOM   3223  C  CB    . PRO A 1 550 ? 93.195  114.374 109.964 1.00 57.84  ? 542 PRO A CB    1 
ATOM   3224  C  CG    . PRO A 1 550 ? 94.110  113.240 109.663 1.00 54.23  ? 542 PRO A CG    1 
ATOM   3225  C  CD    . PRO A 1 550 ? 95.405  113.531 110.379 1.00 57.13  ? 542 PRO A CD    1 
ATOM   3226  N  N     . VAL A 1 551 ? 92.866  114.404 113.686 1.00 52.35  ? 543 VAL A N     1 
ATOM   3227  C  CA    . VAL A 1 551 ? 92.219  113.690 114.783 1.00 51.95  ? 543 VAL A CA    1 
ATOM   3228  C  C     . VAL A 1 551 ? 90.701  113.756 114.647 1.00 52.90  ? 543 VAL A C     1 
ATOM   3229  O  O     . VAL A 1 551 ? 90.001  112.746 114.791 1.00 52.53  ? 543 VAL A O     1 
ATOM   3230  C  CB    . VAL A 1 551 ? 92.699  114.249 116.134 1.00 52.08  ? 543 VAL A CB    1 
ATOM   3231  C  CG1   . VAL A 1 551 ? 92.656  115.767 116.128 1.00 55.50  ? 543 VAL A CG1   1 
ATOM   3232  C  CG2   . VAL A 1 551 ? 91.863  113.697 117.265 1.00 51.81  ? 543 VAL A CG2   1 
ATOM   3233  N  N     . ASN A 1 552 ? 90.171  114.945 114.353 1.00 52.93  ? 544 ASN A N     1 
ATOM   3234  C  CA    . ASN A 1 552 ? 88.724  115.098 114.229 1.00 48.66  ? 544 ASN A CA    1 
ATOM   3235  C  C     . ASN A 1 552 ? 88.189  114.376 113.000 1.00 47.64  ? 544 ASN A C     1 
ATOM   3236  O  O     . ASN A 1 552 ? 87.100  113.793 113.043 1.00 46.75  ? 544 ASN A O     1 
ATOM   3237  C  CB    . ASN A 1 552 ? 88.355  116.577 114.188 1.00 50.28  ? 544 ASN A CB    1 
ATOM   3238  C  CG    . ASN A 1 552 ? 88.451  117.237 115.547 1.00 54.21  ? 544 ASN A CG    1 
ATOM   3239  O  OD1   . ASN A 1 552 ? 88.213  116.604 116.574 1.00 52.99  ? 544 ASN A OD1   1 
ATOM   3240  N  ND2   . ASN A 1 552 ? 88.799  118.516 115.559 1.00 56.69  ? 544 ASN A ND2   1 
ATOM   3241  N  N     . LEU A 1 553 ? 88.931  114.412 111.891 1.00 49.31  ? 545 LEU A N     1 
ATOM   3242  C  CA    . LEU A 1 553 ? 88.515  113.668 110.707 1.00 49.63  ? 545 LEU A CA    1 
ATOM   3243  C  C     . LEU A 1 553 ? 88.460  112.174 110.991 1.00 46.68  ? 545 LEU A C     1 
ATOM   3244  O  O     . LEU A 1 553 ? 87.507  111.493 110.595 1.00 48.91  ? 545 LEU A O     1 
ATOM   3245  C  CB    . LEU A 1 553 ? 89.462  113.958 109.545 1.00 50.42  ? 545 LEU A CB    1 
ATOM   3246  C  CG    . LEU A 1 553 ? 89.329  113.034 108.332 1.00 52.01  ? 545 LEU A CG    1 
ATOM   3247  C  CD1   . LEU A 1 553 ? 87.962  113.184 107.684 1.00 52.21  ? 545 LEU A CD1   1 
ATOM   3248  C  CD2   . LEU A 1 553 ? 90.435  113.301 107.330 1.00 54.23  ? 545 LEU A CD2   1 
ATOM   3249  N  N     . LEU A 1 554 ? 89.474  111.648 111.682 1.00 45.90  ? 546 LEU A N     1 
ATOM   3250  C  CA    . LEU A 1 554 ? 89.478  110.233 112.036 1.00 45.83  ? 546 LEU A CA    1 
ATOM   3251  C  C     . LEU A 1 554 ? 88.322  109.893 112.967 1.00 44.37  ? 546 LEU A C     1 
ATOM   3252  O  O     . LEU A 1 554 ? 87.691  108.838 112.827 1.00 44.75  ? 546 LEU A O     1 
ATOM   3253  C  CB    . LEU A 1 554 ? 90.813  109.862 112.675 1.00 44.73  ? 546 LEU A CB    1 
ATOM   3254  C  CG    . LEU A 1 554 ? 92.011  109.844 111.728 1.00 45.03  ? 546 LEU A CG    1 
ATOM   3255  C  CD1   . LEU A 1 554 ? 93.302  109.825 112.514 1.00 49.62  ? 546 LEU A CD1   1 
ATOM   3256  C  CD2   . LEU A 1 554 ? 91.934  108.643 110.807 1.00 40.09  ? 546 LEU A CD2   1 
ATOM   3257  N  N     . ARG A 1 555 ? 88.035  110.771 113.929 1.00 46.05  ? 547 ARG A N     1 
ATOM   3258  C  CA    . ARG A 1 555 ? 86.905  110.538 114.822 1.00 44.29  ? 547 ARG A CA    1 
ATOM   3259  C  C     . ARG A 1 555 ? 85.591  110.520 114.054 1.00 46.33  ? 547 ARG A C     1 
ATOM   3260  O  O     . ARG A 1 555 ? 84.726  109.678 114.315 1.00 46.58  ? 547 ARG A O     1 
ATOM   3261  C  CB    . ARG A 1 555 ? 86.878  111.599 115.919 1.00 42.41  ? 547 ARG A CB    1 
ATOM   3262  C  CG    . ARG A 1 555 ? 87.929  111.391 116.987 1.00 43.97  ? 547 ARG A CG    1 
ATOM   3263  C  CD    . ARG A 1 555 ? 88.117  112.633 117.830 1.00 42.44  ? 547 ARG A CD    1 
ATOM   3264  N  NE    . ARG A 1 555 ? 89.005  112.385 118.957 1.00 44.84  ? 547 ARG A NE    1 
ATOM   3265  C  CZ    . ARG A 1 555 ? 89.539  113.334 119.711 1.00 52.23  ? 547 ARG A CZ    1 
ATOM   3266  N  NH1   . ARG A 1 555 ? 89.310  114.614 119.473 1.00 53.27  ? 547 ARG A NH1   1 
ATOM   3267  N  NH2   . ARG A 1 555 ? 90.331  112.992 120.723 1.00 58.80  ? 547 ARG A NH2   1 
ATOM   3268  N  N     . ASN A 1 556 ? 85.421  111.444 113.106 1.00 45.41  ? 548 ASN A N     1 
ATOM   3269  C  CA    . ASN A 1 556 ? 84.207  111.458 112.296 1.00 45.15  ? 548 ASN A CA    1 
ATOM   3270  C  C     . ASN A 1 556 ? 84.087  110.191 111.461 1.00 41.93  ? 548 ASN A C     1 
ATOM   3271  O  O     . ASN A 1 556 ? 82.997  109.621 111.336 1.00 41.56  ? 548 ASN A O     1 
ATOM   3272  C  CB    . ASN A 1 556 ? 84.186  112.693 111.398 1.00 48.59  ? 548 ASN A CB    1 
ATOM   3273  C  CG    . ASN A 1 556 ? 83.964  113.972 112.174 1.00 48.71  ? 548 ASN A CG    1 
ATOM   3274  O  OD1   . ASN A 1 556 ? 83.312  113.971 113.216 1.00 48.28  ? 548 ASN A OD1   1 
ATOM   3275  N  ND2   . ASN A 1 556 ? 84.503  115.073 111.667 1.00 48.36  ? 548 ASN A ND2   1 
ATOM   3276  N  N     . VAL A 1 557 ? 85.200  109.738 110.879 1.00 44.09  ? 549 VAL A N     1 
ATOM   3277  C  CA    . VAL A 1 557 ? 85.181  108.508 110.093 1.00 42.09  ? 549 VAL A CA    1 
ATOM   3278  C  C     . VAL A 1 557 ? 84.783  107.325 110.965 1.00 41.83  ? 549 VAL A C     1 
ATOM   3279  O  O     . VAL A 1 557 ? 83.967  106.487 110.566 1.00 44.32  ? 549 VAL A O     1 
ATOM   3280  C  CB    . VAL A 1 557 ? 86.548  108.280 109.421 1.00 36.45  ? 549 VAL A CB    1 
ATOM   3281  C  CG1   . VAL A 1 557 ? 86.603  106.904 108.789 1.00 39.63  ? 549 VAL A CG1   1 
ATOM   3282  C  CG2   . VAL A 1 557 ? 86.808  109.348 108.376 1.00 36.90  ? 549 VAL A CG2   1 
ATOM   3283  N  N     . ALA A 1 558 ? 85.351  107.239 112.168 1.00 39.79  ? 550 ALA A N     1 
ATOM   3284  C  CA    . ALA A 1 558 ? 85.021  106.135 113.063 1.00 41.49  ? 550 ALA A CA    1 
ATOM   3285  C  C     . ALA A 1 558 ? 83.563  106.188 113.505 1.00 43.58  ? 550 ALA A C     1 
ATOM   3286  O  O     . ALA A 1 558 ? 82.894  105.151 113.575 1.00 41.12  ? 550 ALA A O     1 
ATOM   3287  C  CB    . ALA A 1 558 ? 85.952  106.149 114.274 1.00 38.29  ? 550 ALA A CB    1 
ATOM   3288  N  N     . MET A 1 559 ? 83.055  107.385 113.813 1.00 43.01  ? 551 MET A N     1 
ATOM   3289  C  CA    . MET A 1 559 ? 81.684  107.516 114.296 1.00 36.95  ? 551 MET A CA    1 
ATOM   3290  C  C     . MET A 1 559 ? 80.672  107.205 113.204 1.00 44.25  ? 551 MET A C     1 
ATOM   3291  O  O     . MET A 1 559 ? 79.673  106.519 113.451 1.00 45.90  ? 551 MET A O     1 
ATOM   3292  C  CB    . MET A 1 559 ? 81.450  108.927 114.829 1.00 35.88  ? 551 MET A CB    1 
ATOM   3293  C  CG    . MET A 1 559 ? 82.199  109.259 116.096 1.00 51.24  ? 551 MET A CG    1 
ATOM   3294  S  SD    . MET A 1 559 ? 82.410  111.037 116.279 1.00 58.63  ? 551 MET A SD    1 
ATOM   3295  C  CE    . MET A 1 559 ? 80.757  111.614 115.916 1.00 44.93  ? 551 MET A CE    1 
ATOM   3296  N  N     . LYS A 1 560 ? 80.909  107.709 111.991 1.00 45.16  ? 552 LYS A N     1 
ATOM   3297  C  CA    . LYS A 1 560 ? 79.915  107.626 110.929 1.00 39.96  ? 552 LYS A CA    1 
ATOM   3298  C  C     . LYS A 1 560 ? 79.634  106.193 110.500 1.00 44.17  ? 552 LYS A C     1 
ATOM   3299  O  O     . LYS A 1 560 ? 78.555  105.919 109.963 1.00 44.06  ? 552 LYS A O     1 
ATOM   3300  C  CB    . LYS A 1 560 ? 80.383  108.455 109.732 1.00 43.60  ? 552 LYS A CB    1 
ATOM   3301  C  CG    . LYS A 1 560 ? 79.347  108.642 108.639 1.00 51.86  ? 552 LYS A CG    1 
ATOM   3302  C  CD    . LYS A 1 560 ? 79.898  109.500 107.513 1.00 55.58  ? 552 LYS A CD    1 
ATOM   3303  C  CE    . LYS A 1 560 ? 78.890  109.653 106.389 1.00 61.54  ? 552 LYS A CE    1 
ATOM   3304  N  NZ    . LYS A 1 560 ? 79.428  110.492 105.283 1.00 69.57  ? 552 LYS A NZ    1 
ATOM   3305  N  N     . HIS A 1 561 ? 80.560  105.271 110.738 1.00 43.24  ? 553 HIS A N     1 
ATOM   3306  C  CA    . HIS A 1 561 ? 80.471  103.916 110.214 1.00 40.30  ? 553 HIS A CA    1 
ATOM   3307  C  C     . HIS A 1 561 ? 80.373  102.886 111.333 1.00 41.50  ? 553 HIS A C     1 
ATOM   3308  O  O     . HIS A 1 561 ? 81.036  101.849 111.308 1.00 42.83  ? 553 HIS A O     1 
ATOM   3309  C  CB    . HIS A 1 561 ? 81.655  103.622 109.298 1.00 40.08  ? 553 HIS A CB    1 
ATOM   3310  C  CG    . HIS A 1 561 ? 81.817  104.619 108.195 1.00 42.42  ? 553 HIS A CG    1 
ATOM   3311  N  ND1   . HIS A 1 561 ? 80.960  104.682 107.118 1.00 47.50  ? 553 HIS A ND1   1 
ATOM   3312  C  CD2   . HIS A 1 561 ? 82.727  105.604 108.009 1.00 41.78  ? 553 HIS A CD2   1 
ATOM   3313  C  CE1   . HIS A 1 561 ? 81.338  105.658 106.313 1.00 47.12  ? 553 HIS A CE1   1 
ATOM   3314  N  NE2   . HIS A 1 561 ? 82.409  106.233 106.830 1.00 48.97  ? 553 HIS A NE2   1 
ATOM   3315  N  N     . ILE A 1 562 ? 79.540  103.163 112.329 1.00 43.63  ? 554 ILE A N     1 
ATOM   3316  C  CA    . ILE A 1 562 ? 79.270  102.219 113.398 1.00 45.93  ? 554 ILE A CA    1 
ATOM   3317  C  C     . ILE A 1 562 ? 78.005  101.448 113.051 1.00 51.28  ? 554 ILE A C     1 
ATOM   3318  O  O     . ILE A 1 562 ? 77.212  101.849 112.196 1.00 55.58  ? 554 ILE A O     1 
ATOM   3319  C  CB    . ILE A 1 562 ? 79.135  102.915 114.769 1.00 47.14  ? 554 ILE A CB    1 
ATOM   3320  C  CG1   . ILE A 1 562 ? 77.889  103.797 114.796 1.00 53.70  ? 554 ILE A CG1   1 
ATOM   3321  C  CG2   . ILE A 1 562 ? 80.372  103.737 115.071 1.00 45.55  ? 554 ILE A CG2   1 
ATOM   3322  C  CD1   . ILE A 1 562 ? 77.643  104.460 116.129 1.00 52.73  ? 554 ILE A CD1   1 
ATOM   3323  N  N     . SER A 1 563 ? 77.812  100.315 113.725 1.00 50.65  ? 555 SER A N     1 
ATOM   3324  C  CA    . SER A 1 563 ? 76.670  99.446  113.475 1.00 58.05  ? 555 SER A CA    1 
ATOM   3325  C  C     . SER A 1 563 ? 75.704  99.384  114.651 1.00 63.42  ? 555 SER A C     1 
ATOM   3326  O  O     . SER A 1 563 ? 74.834  98.509  114.678 1.00 68.66  ? 555 SER A O     1 
ATOM   3327  C  CB    . SER A 1 563 ? 77.150  98.037  113.122 1.00 57.73  ? 555 SER A CB    1 
ATOM   3328  O  OG    . SER A 1 563 ? 78.027  98.062  112.010 1.00 60.71  ? 555 SER A OG    1 
ATOM   3329  N  N     . THR A 1 564 ? 75.830  100.288 115.617 1.00 57.68  ? 556 THR A N     1 
ATOM   3330  C  CA    . THR A 1 564 ? 75.033  100.239 116.830 1.00 56.12  ? 556 THR A CA    1 
ATOM   3331  C  C     . THR A 1 564 ? 74.380  101.587 117.089 1.00 61.61  ? 556 THR A C     1 
ATOM   3332  O  O     . THR A 1 564 ? 74.909  102.627 116.683 1.00 63.74  ? 556 THR A O     1 
ATOM   3333  C  CB    . THR A 1 564 ? 75.895  99.848  118.039 1.00 59.27  ? 556 THR A CB    1 
ATOM   3334  O  OG1   . THR A 1 564 ? 76.957  100.795 118.193 1.00 58.35  ? 556 THR A OG1   1 
ATOM   3335  C  CG2   . THR A 1 564 ? 76.483  98.461  117.845 1.00 58.32  ? 556 THR A CG2   1 
ATOM   3336  N  N     . PRO A 1 565 ? 73.222  101.599 117.756 1.00 61.14  ? 557 PRO A N     1 
ATOM   3337  C  CA    . PRO A 1 565 ? 72.548  102.879 118.029 1.00 61.04  ? 557 PRO A CA    1 
ATOM   3338  C  C     . PRO A 1 565 ? 73.353  103.832 118.896 1.00 59.46  ? 557 PRO A C     1 
ATOM   3339  O  O     . PRO A 1 565 ? 73.211  105.052 118.749 1.00 58.47  ? 557 PRO A O     1 
ATOM   3340  C  CB    . PRO A 1 565 ? 71.249  102.446 118.724 1.00 60.98  ? 557 PRO A CB    1 
ATOM   3341  C  CG    . PRO A 1 565 ? 71.527  101.078 119.244 1.00 59.83  ? 557 PRO A CG    1 
ATOM   3342  C  CD    . PRO A 1 565 ? 72.439  100.452 118.243 1.00 57.62  ? 557 PRO A CD    1 
ATOM   3343  N  N     . TYR A 1 566 ? 74.186  103.322 119.798 1.00 56.38  ? 558 TYR A N     1 
ATOM   3344  C  CA    . TYR A 1 566 ? 74.940  104.156 120.722 1.00 54.26  ? 558 TYR A CA    1 
ATOM   3345  C  C     . TYR A 1 566 ? 76.432  103.928 120.535 1.00 52.26  ? 558 TYR A C     1 
ATOM   3346  O  O     . TYR A 1 566 ? 76.870  102.831 120.180 1.00 54.48  ? 558 TYR A O     1 
ATOM   3347  C  CB    . TYR A 1 566 ? 74.546  103.871 122.175 1.00 58.66  ? 558 TYR A CB    1 
ATOM   3348  C  CG    . TYR A 1 566 ? 73.057  103.919 122.410 1.00 61.72  ? 558 TYR A CG    1 
ATOM   3349  C  CD1   . TYR A 1 566 ? 72.417  105.118 122.684 1.00 62.62  ? 558 TYR A CD1   1 
ATOM   3350  C  CD2   . TYR A 1 566 ? 72.289  102.765 122.348 1.00 64.81  ? 558 TYR A CD2   1 
ATOM   3351  C  CE1   . TYR A 1 566 ? 71.055  105.166 122.894 1.00 69.79  ? 558 TYR A CE1   1 
ATOM   3352  C  CE2   . TYR A 1 566 ? 70.928  102.802 122.556 1.00 68.40  ? 558 TYR A CE2   1 
ATOM   3353  C  CZ    . TYR A 1 566 ? 70.315  104.004 122.829 1.00 73.02  ? 558 TYR A CZ    1 
ATOM   3354  O  OH    . TYR A 1 566 ? 68.957  104.043 123.038 1.00 82.77  ? 558 TYR A OH    1 
ATOM   3355  N  N     . MET A 1 567 ? 77.210  104.981 120.773 1.00 49.03  ? 559 MET A N     1 
ATOM   3356  C  CA    . MET A 1 567 ? 78.652  104.922 120.600 1.00 48.10  ? 559 MET A CA    1 
ATOM   3357  C  C     . MET A 1 567 ? 79.353  105.590 121.773 1.00 45.73  ? 559 MET A C     1 
ATOM   3358  O  O     . MET A 1 567 ? 78.897  106.618 122.282 1.00 48.02  ? 559 MET A O     1 
ATOM   3359  C  CB    . MET A 1 567 ? 79.085  105.586 119.288 1.00 48.74  ? 559 MET A CB    1 
ATOM   3360  C  CG    . MET A 1 567 ? 78.652  107.029 119.145 1.00 47.86  ? 559 MET A CG    1 
ATOM   3361  S  SD    . MET A 1 567 ? 79.217  107.757 117.600 1.00 48.93  ? 559 MET A SD    1 
ATOM   3362  C  CE    . MET A 1 567 ? 78.569  109.414 117.762 1.00 52.72  ? 559 MET A CE    1 
ATOM   3363  N  N     . PHE A 1 568 ? 80.468  104.996 122.188 1.00 42.67  ? 560 PHE A N     1 
ATOM   3364  C  CA    . PHE A 1 568 ? 81.315  105.525 123.251 1.00 39.86  ? 560 PHE A CA    1 
ATOM   3365  C  C     . PHE A 1 568 ? 82.527  106.179 122.598 1.00 39.53  ? 560 PHE A C     1 
ATOM   3366  O  O     . PHE A 1 568 ? 83.356  105.494 121.990 1.00 38.68  ? 560 PHE A O     1 
ATOM   3367  C  CB    . PHE A 1 568 ? 81.724  104.403 124.205 1.00 39.83  ? 560 PHE A CB    1 
ATOM   3368  C  CG    . PHE A 1 568 ? 82.699  104.821 125.273 1.00 40.62  ? 560 PHE A CG    1 
ATOM   3369  C  CD1   . PHE A 1 568 ? 82.777  106.135 125.701 1.00 42.26  ? 560 PHE A CD1   1 
ATOM   3370  C  CD2   . PHE A 1 568 ? 83.541  103.886 125.849 1.00 37.33  ? 560 PHE A CD2   1 
ATOM   3371  C  CE1   . PHE A 1 568 ? 83.675  106.506 126.676 1.00 43.80  ? 560 PHE A CE1   1 
ATOM   3372  C  CE2   . PHE A 1 568 ? 84.438  104.254 126.826 1.00 40.84  ? 560 PHE A CE2   1 
ATOM   3373  C  CZ    . PHE A 1 568 ? 84.503  105.565 127.239 1.00 45.78  ? 560 PHE A CZ    1 
ATOM   3374  N  N     . LEU A 1 569 ? 82.637  107.503 122.727 1.00 41.16  ? 561 LEU A N     1 
ATOM   3375  C  CA    . LEU A 1 569 ? 83.724  108.249 122.093 1.00 41.35  ? 561 LEU A CA    1 
ATOM   3376  C  C     . LEU A 1 569 ? 84.969  108.179 122.977 1.00 42.15  ? 561 LEU A C     1 
ATOM   3377  O  O     . LEU A 1 569 ? 85.402  109.154 123.595 1.00 42.89  ? 561 LEU A O     1 
ATOM   3378  C  CB    . LEU A 1 569 ? 83.302  109.687 121.829 1.00 43.94  ? 561 LEU A CB    1 
ATOM   3379  C  CG    . LEU A 1 569 ? 82.051  109.868 120.969 1.00 43.44  ? 561 LEU A CG    1 
ATOM   3380  C  CD1   . LEU A 1 569 ? 81.848  111.329 120.622 1.00 45.33  ? 561 LEU A CD1   1 
ATOM   3381  C  CD2   . LEU A 1 569 ? 82.143  109.024 119.712 1.00 42.95  ? 561 LEU A CD2   1 
ATOM   3382  N  N     . SER A 1 570 ? 85.555  106.987 123.016 1.00 43.91  ? 562 SER A N     1 
ATOM   3383  C  CA    . SER A 1 570 ? 86.718  106.723 123.851 1.00 46.58  ? 562 SER A CA    1 
ATOM   3384  C  C     . SER A 1 570 ? 87.993  107.171 123.140 1.00 44.43  ? 562 SER A C     1 
ATOM   3385  O  O     . SER A 1 570 ? 87.963  107.916 122.158 1.00 46.81  ? 562 SER A O     1 
ATOM   3386  C  CB    . SER A 1 570 ? 86.752  105.252 124.254 1.00 48.54  ? 562 SER A CB    1 
ATOM   3387  O  OG    . SER A 1 570 ? 87.932  104.954 124.976 1.00 53.30  ? 562 SER A OG    1 
ATOM   3388  N  N     . ASP A 1 571 ? 89.137  106.720 123.644 1.00 47.04  ? 563 ASP A N     1 
ATOM   3389  C  CA    . ASP A 1 571 ? 90.430  107.012 123.049 1.00 50.59  ? 563 ASP A CA    1 
ATOM   3390  C  C     . ASP A 1 571 ? 91.261  105.737 123.070 1.00 49.25  ? 563 ASP A C     1 
ATOM   3391  O  O     . ASP A 1 571 ? 91.020  104.827 123.867 1.00 46.45  ? 563 ASP A O     1 
ATOM   3392  C  CB    . ASP A 1 571 ? 91.164  108.148 123.772 1.00 51.55  ? 563 ASP A CB    1 
ATOM   3393  C  CG    . ASP A 1 571 ? 92.030  108.969 122.840 1.00 57.68  ? 563 ASP A CG    1 
ATOM   3394  O  OD1   . ASP A 1 571 ? 92.656  108.386 121.932 1.00 57.00  ? 563 ASP A OD1   1 
ATOM   3395  O  OD2   . ASP A 1 571 ? 92.080  110.203 123.015 1.00 60.15  ? 563 ASP A OD2   1 
ATOM   3396  N  N     . ILE A 1 572 ? 92.245  105.672 122.168 1.00 49.83  ? 564 ILE A N     1 
ATOM   3397  C  CA    . ILE A 1 572 ? 93.046  104.461 122.042 1.00 48.94  ? 564 ILE A CA    1 
ATOM   3398  C  C     . ILE A 1 572 ? 94.008  104.295 123.210 1.00 47.23  ? 564 ILE A C     1 
ATOM   3399  O  O     . ILE A 1 572 ? 94.475  103.179 123.466 1.00 45.93  ? 564 ILE A O     1 
ATOM   3400  C  CB    . ILE A 1 572 ? 93.807  104.450 120.702 1.00 47.84  ? 564 ILE A CB    1 
ATOM   3401  C  CG1   . ILE A 1 572 ? 93.828  103.040 120.118 1.00 41.17  ? 564 ILE A CG1   1 
ATOM   3402  C  CG2   . ILE A 1 572 ? 95.226  104.967 120.872 1.00 50.20  ? 564 ILE A CG2   1 
ATOM   3403  C  CD1   . ILE A 1 572 ? 92.477  102.561 119.659 1.00 41.83  ? 564 ILE A CD1   1 
ATOM   3404  N  N     . ASP A 1 573 ? 94.313  105.370 123.932 1.00 50.36  ? 565 ASP A N     1 
ATOM   3405  C  CA    . ASP A 1 573 ? 95.225  105.318 125.065 1.00 46.73  ? 565 ASP A CA    1 
ATOM   3406  C  C     . ASP A 1 573 ? 94.536  104.929 126.363 1.00 39.16  ? 565 ASP A C     1 
ATOM   3407  O  O     . ASP A 1 573 ? 95.207  104.820 127.393 1.00 46.24  ? 565 ASP A O     1 
ATOM   3408  C  CB    . ASP A 1 573 ? 95.918  106.670 125.248 1.00 48.58  ? 565 ASP A CB    1 
ATOM   3409  C  CG    . ASP A 1 573 ? 96.865  106.996 124.118 1.00 54.78  ? 565 ASP A CG    1 
ATOM   3410  O  OD1   . ASP A 1 573 ? 97.510  106.066 123.592 1.00 52.98  ? 565 ASP A OD1   1 
ATOM   3411  O  OD2   . ASP A 1 573 ? 96.964  108.185 123.755 1.00 56.19  ? 565 ASP A OD2   1 
ATOM   3412  N  N     . PHE A 1 574 ? 93.226  104.721 126.343 1.00 40.43  ? 566 PHE A N     1 
ATOM   3413  C  CA    . PHE A 1 574 ? 92.452  104.448 127.544 1.00 40.20  ? 566 PHE A CA    1 
ATOM   3414  C  C     . PHE A 1 574 ? 91.996  102.998 127.549 1.00 39.23  ? 566 PHE A C     1 
ATOM   3415  O  O     . PHE A 1 574 ? 91.332  102.548 126.610 1.00 45.87  ? 566 PHE A O     1 
ATOM   3416  C  CB    . PHE A 1 574 ? 91.239  105.374 127.632 1.00 41.16  ? 566 PHE A CB    1 
ATOM   3417  C  CG    . PHE A 1 574 ? 91.573  106.780 128.032 1.00 42.21  ? 566 PHE A CG    1 
ATOM   3418  C  CD1   . PHE A 1 574 ? 92.215  107.631 127.152 1.00 44.97  ? 566 PHE A CD1   1 
ATOM   3419  C  CD2   . PHE A 1 574 ? 91.233  107.254 129.286 1.00 42.09  ? 566 PHE A CD2   1 
ATOM   3420  C  CE1   . PHE A 1 574 ? 92.520  108.924 127.518 1.00 46.71  ? 566 PHE A CE1   1 
ATOM   3421  C  CE2   . PHE A 1 574 ? 91.535  108.545 129.656 1.00 45.76  ? 566 PHE A CE2   1 
ATOM   3422  C  CZ    . PHE A 1 574 ? 92.179  109.382 128.772 1.00 47.80  ? 566 PHE A CZ    1 
ATOM   3423  N  N     . LEU A 1 575 ? 92.347  102.281 128.599 1.00 37.17  ? 567 LEU A N     1 
ATOM   3424  C  CA    . LEU A 1 575 ? 91.842  100.938 128.826 1.00 39.89  ? 567 LEU A CA    1 
ATOM   3425  C  C     . LEU A 1 575 ? 90.599  101.002 129.694 1.00 42.77  ? 567 LEU A C     1 
ATOM   3426  O  O     . LEU A 1 575 ? 90.640  101.602 130.779 1.00 52.23  ? 567 LEU A O     1 
ATOM   3427  C  CB    . LEU A 1 575 ? 92.899  100.066 129.498 1.00 44.81  ? 567 LEU A CB    1 
ATOM   3428  C  CG    . LEU A 1 575 ? 94.112  99.686  128.651 1.00 48.20  ? 567 LEU A CG    1 
ATOM   3429  C  CD1   . LEU A 1 575 ? 95.035  98.761  129.426 1.00 53.20  ? 567 LEU A CD1   1 
ATOM   3430  C  CD2   . LEU A 1 575 ? 93.668  99.036  127.356 1.00 47.06  ? 567 LEU A CD2   1 
ATOM   3431  N  N     . PRO A 1 576 ? 89.487  100.432 129.250 1.00 39.25  ? 568 PRO A N     1 
ATOM   3432  C  CA    . PRO A 1 576 ? 88.273  100.420 130.068 1.00 45.71  ? 568 PRO A CA    1 
ATOM   3433  C  C     . PRO A 1 576 ? 88.310  99.292  131.091 1.00 49.84  ? 568 PRO A C     1 
ATOM   3434  O  O     . PRO A 1 576 ? 89.186  98.429  131.081 1.00 53.55  ? 568 PRO A O     1 
ATOM   3435  C  CB    . PRO A 1 576 ? 87.168  100.193 129.037 1.00 42.71  ? 568 PRO A CB    1 
ATOM   3436  C  CG    . PRO A 1 576 ? 87.828  99.363  127.994 1.00 44.34  ? 568 PRO A CG    1 
ATOM   3437  C  CD    . PRO A 1 576 ? 89.260  99.836  127.922 1.00 43.24  ? 568 PRO A CD    1 
ATOM   3438  N  N     . MET A 1 577 ? 87.329  99.319  131.987 1.00 46.25  ? 569 MET A N     1 
ATOM   3439  C  CA    . MET A 1 577 ? 87.201  98.267  132.979 1.00 47.75  ? 569 MET A CA    1 
ATOM   3440  C  C     . MET A 1 577 ? 86.591  97.018  132.353 1.00 54.32  ? 569 MET A C     1 
ATOM   3441  O  O     . MET A 1 577 ? 85.983  97.060  131.281 1.00 60.35  ? 569 MET A O     1 
ATOM   3442  C  CB    . MET A 1 577 ? 86.340  98.728  134.153 1.00 52.95  ? 569 MET A CB    1 
ATOM   3443  C  CG    . MET A 1 577 ? 84.849  98.640  133.892 1.00 51.16  ? 569 MET A CG    1 
ATOM   3444  S  SD    . MET A 1 577 ? 83.858  98.976  135.358 1.00 59.86  ? 569 MET A SD    1 
ATOM   3445  C  CE    . MET A 1 577 ? 82.225  98.555  134.759 1.00 58.30  ? 569 MET A CE    1 
ATOM   3446  N  N     . TYR A 1 578 ? 86.770  95.892  133.036 1.00 55.44  ? 570 TYR A N     1 
ATOM   3447  C  CA    . TYR A 1 578 ? 86.163  94.647  132.588 1.00 57.73  ? 570 TYR A CA    1 
ATOM   3448  C  C     . TYR A 1 578 ? 84.650  94.709  132.753 1.00 60.37  ? 570 TYR A C     1 
ATOM   3449  O  O     . TYR A 1 578 ? 84.139  95.179  133.772 1.00 58.02  ? 570 TYR A O     1 
ATOM   3450  C  CB    . TYR A 1 578 ? 86.729  93.464  133.373 1.00 59.17  ? 570 TYR A CB    1 
ATOM   3451  C  CG    . TYR A 1 578 ? 88.209  93.238  133.167 1.00 61.25  ? 570 TYR A CG    1 
ATOM   3452  C  CD1   . TYR A 1 578 ? 89.147  93.915  133.935 1.00 63.92  ? 570 TYR A CD1   1 
ATOM   3453  C  CD2   . TYR A 1 578 ? 88.668  92.345  132.209 1.00 60.99  ? 570 TYR A CD2   1 
ATOM   3454  C  CE1   . TYR A 1 578 ? 90.499  93.712  133.751 1.00 64.79  ? 570 TYR A CE1   1 
ATOM   3455  C  CE2   . TYR A 1 578 ? 90.019  92.136  132.019 1.00 61.06  ? 570 TYR A CE2   1 
ATOM   3456  C  CZ    . TYR A 1 578 ? 90.930  92.821  132.794 1.00 63.45  ? 570 TYR A CZ    1 
ATOM   3457  O  OH    . TYR A 1 578 ? 92.277  92.617  132.609 1.00 66.18  ? 570 TYR A OH    1 
ATOM   3458  N  N     . GLY A 1 579 ? 83.933  94.232  131.739 1.00 62.00  ? 571 GLY A N     1 
ATOM   3459  C  CA    . GLY A 1 579 ? 82.487  94.242  131.783 1.00 60.52  ? 571 GLY A CA    1 
ATOM   3460  C  C     . GLY A 1 579 ? 81.843  95.591  131.567 1.00 59.79  ? 571 GLY A C     1 
ATOM   3461  O  O     . GLY A 1 579 ? 80.646  95.736  131.834 1.00 60.75  ? 571 GLY A O     1 
ATOM   3462  N  N     . LEU A 1 580 ? 82.599  96.588  131.098 1.00 59.31  ? 572 LEU A N     1 
ATOM   3463  C  CA    . LEU A 1 580 ? 82.017  97.902  130.846 1.00 55.37  ? 572 LEU A CA    1 
ATOM   3464  C  C     . LEU A 1 580 ? 80.995  97.857  129.717 1.00 55.41  ? 572 LEU A C     1 
ATOM   3465  O  O     . LEU A 1 580 ? 80.085  98.691  129.673 1.00 56.80  ? 572 LEU A O     1 
ATOM   3466  C  CB    . LEU A 1 580 ? 83.120  98.912  130.526 1.00 51.34  ? 572 LEU A CB    1 
ATOM   3467  C  CG    . LEU A 1 580 ? 82.683  100.365 130.341 1.00 44.63  ? 572 LEU A CG    1 
ATOM   3468  C  CD1   . LEU A 1 580 ? 81.973  100.865 131.583 1.00 48.55  ? 572 LEU A CD1   1 
ATOM   3469  C  CD2   . LEU A 1 580 ? 83.868  101.252 130.009 1.00 43.25  ? 572 LEU A CD2   1 
ATOM   3470  N  N     . TYR A 1 581 ? 81.125  96.894  128.805 1.00 53.80  ? 573 TYR A N     1 
ATOM   3471  C  CA    . TYR A 1 581 ? 80.172  96.769  127.706 1.00 52.32  ? 573 TYR A CA    1 
ATOM   3472  C  C     . TYR A 1 581 ? 78.764  96.505  128.230 1.00 57.47  ? 573 TYR A C     1 
ATOM   3473  O  O     . TYR A 1 581 ? 77.817  97.231  127.899 1.00 61.06  ? 573 TYR A O     1 
ATOM   3474  C  CB    . TYR A 1 581 ? 80.636  95.655  126.765 1.00 51.36  ? 573 TYR A CB    1 
ATOM   3475  C  CG    . TYR A 1 581 ? 79.682  95.305  125.648 1.00 54.95  ? 573 TYR A CG    1 
ATOM   3476  C  CD1   . TYR A 1 581 ? 79.486  96.165  124.577 1.00 54.65  ? 573 TYR A CD1   1 
ATOM   3477  C  CD2   . TYR A 1 581 ? 78.999  94.097  125.649 1.00 59.34  ? 573 TYR A CD2   1 
ATOM   3478  C  CE1   . TYR A 1 581 ? 78.621  95.841  123.551 1.00 57.55  ? 573 TYR A CE1   1 
ATOM   3479  C  CE2   . TYR A 1 581 ? 78.134  93.764  124.627 1.00 61.61  ? 573 TYR A CE2   1 
ATOM   3480  C  CZ    . TYR A 1 581 ? 77.949  94.639  123.581 1.00 61.68  ? 573 TYR A CZ    1 
ATOM   3481  O  OH    . TYR A 1 581 ? 77.087  94.309  122.563 1.00 61.28  ? 573 TYR A OH    1 
ATOM   3482  N  N     . GLU A 1 582 ? 78.615  95.487  129.080 1.00 58.04  ? 574 GLU A N     1 
ATOM   3483  C  CA    . GLU A 1 582 ? 77.308  95.188  129.654 1.00 61.57  ? 574 GLU A CA    1 
ATOM   3484  C  C     . GLU A 1 582 ? 76.839  96.294  130.589 1.00 61.93  ? 574 GLU A C     1 
ATOM   3485  O  O     . GLU A 1 582 ? 75.636  96.575  130.660 1.00 63.54  ? 574 GLU A O     1 
ATOM   3486  C  CB    . GLU A 1 582 ? 77.353  93.850  130.390 1.00 60.28  ? 574 GLU A CB    1 
ATOM   3487  C  CG    . GLU A 1 582 ? 77.655  92.665  129.490 1.00 67.46  ? 574 GLU A CG    1 
ATOM   3488  C  CD    . GLU A 1 582 ? 76.563  92.415  128.468 1.00 76.00  ? 574 GLU A CD    1 
ATOM   3489  O  OE1   . GLU A 1 582 ? 75.388  92.718  128.762 1.00 76.45  ? 574 GLU A OE1   1 
ATOM   3490  O  OE2   . GLU A 1 582 ? 76.881  91.917  127.368 1.00 79.32  ? 574 GLU A OE2   1 
ATOM   3491  N  N     . TYR A 1 583 ? 77.764  96.931  131.308 1.00 58.24  ? 575 TYR A N     1 
ATOM   3492  C  CA    . TYR A 1 583 ? 77.377  98.023  132.193 1.00 57.92  ? 575 TYR A CA    1 
ATOM   3493  C  C     . TYR A 1 583 ? 76.780  99.182  131.408 1.00 63.22  ? 575 TYR A C     1 
ATOM   3494  O  O     . TYR A 1 583 ? 75.762  99.753  131.811 1.00 68.26  ? 575 TYR A O     1 
ATOM   3495  C  CB    . TYR A 1 583 ? 78.577  98.491  133.015 1.00 59.31  ? 575 TYR A CB    1 
ATOM   3496  C  CG    . TYR A 1 583 ? 78.226  99.552  134.031 1.00 63.15  ? 575 TYR A CG    1 
ATOM   3497  C  CD1   . TYR A 1 583 ? 77.460  99.242  135.147 1.00 64.98  ? 575 TYR A CD1   1 
ATOM   3498  C  CD2   . TYR A 1 583 ? 78.658  100.861 133.875 1.00 61.85  ? 575 TYR A CD2   1 
ATOM   3499  C  CE1   . TYR A 1 583 ? 77.133  100.207 136.079 1.00 67.12  ? 575 TYR A CE1   1 
ATOM   3500  C  CE2   . TYR A 1 583 ? 78.337  101.833 134.802 1.00 69.31  ? 575 TYR A CE2   1 
ATOM   3501  C  CZ    . TYR A 1 583 ? 77.574  101.500 135.902 1.00 71.41  ? 575 TYR A CZ    1 
ATOM   3502  O  OH    . TYR A 1 583 ? 77.253  102.466 136.828 1.00 69.15  ? 575 TYR A OH    1 
ATOM   3503  N  N     . LEU A 1 584 ? 77.387  99.536  130.273 1.00 62.16  ? 576 LEU A N     1 
ATOM   3504  C  CA    . LEU A 1 584 ? 76.838  100.611 129.450 1.00 58.11  ? 576 LEU A CA    1 
ATOM   3505  C  C     . LEU A 1 584 ? 75.539  100.185 128.776 1.00 61.10  ? 576 LEU A C     1 
ATOM   3506  O  O     . LEU A 1 584 ? 74.625  101.003 128.606 1.00 63.22  ? 576 LEU A O     1 
ATOM   3507  C  CB    . LEU A 1 584 ? 77.865  101.055 128.412 1.00 53.51  ? 576 LEU A CB    1 
ATOM   3508  C  CG    . LEU A 1 584 ? 79.101  101.762 128.968 1.00 47.60  ? 576 LEU A CG    1 
ATOM   3509  C  CD1   . LEU A 1 584 ? 80.067  102.116 127.852 1.00 43.68  ? 576 LEU A CD1   1 
ATOM   3510  C  CD2   . LEU A 1 584 ? 78.698  103.003 129.739 1.00 45.12  ? 576 LEU A CD2   1 
ATOM   3511  N  N     . ARG A 1 585 ? 75.436  98.911  128.384 1.00 61.82  ? 577 ARG A N     1 
ATOM   3512  C  CA    . ARG A 1 585 ? 74.182  98.425  127.816 1.00 65.80  ? 577 ARG A CA    1 
ATOM   3513  C  C     . ARG A 1 585 ? 73.045  98.492  128.827 1.00 70.37  ? 577 ARG A C     1 
ATOM   3514  O  O     . ARG A 1 585 ? 71.888  98.705  128.446 1.00 76.74  ? 577 ARG A O     1 
ATOM   3515  C  CB    . ARG A 1 585 ? 74.350  96.996  127.301 1.00 65.84  ? 577 ARG A CB    1 
ATOM   3516  C  CG    . ARG A 1 585 ? 75.152  96.895  126.018 1.00 66.21  ? 577 ARG A CG    1 
ATOM   3517  C  CD    . ARG A 1 585 ? 75.127  95.483  125.466 1.00 69.56  ? 577 ARG A CD    1 
ATOM   3518  N  NE    . ARG A 1 585 ? 73.771  95.029  125.187 1.00 74.87  ? 577 ARG A NE    1 
ATOM   3519  C  CZ    . ARG A 1 585 ? 73.472  93.865  124.628 1.00 80.67  ? 577 ARG A CZ    1 
ATOM   3520  N  NH1   . ARG A 1 585 ? 74.415  93.010  124.268 1.00 78.58  ? 577 ARG A NH1   1 
ATOM   3521  N  NH2   . ARG A 1 585 ? 72.196  93.551  124.425 1.00 84.02  ? 577 ARG A NH2   1 
ATOM   3522  N  N     . LYS A 1 586 ? 73.343  98.292  130.110 1.00 66.75  ? 578 LYS A N     1 
ATOM   3523  C  CA    . LYS A 1 586 ? 72.321  98.474  131.136 1.00 66.33  ? 578 LYS A CA    1 
ATOM   3524  C  C     . LYS A 1 586 ? 72.071  99.950  131.423 1.00 70.08  ? 578 LYS A C     1 
ATOM   3525  O  O     . LYS A 1 586 ? 70.932  100.351 131.689 1.00 77.30  ? 578 LYS A O     1 
ATOM   3526  C  CB    . LYS A 1 586 ? 72.722  97.745  132.417 1.00 71.35  ? 578 LYS A CB    1 
ATOM   3527  C  CG    . LYS A 1 586 ? 72.747  96.233  132.290 1.00 72.95  ? 578 LYS A CG    1 
ATOM   3528  C  CD    . LYS A 1 586 ? 73.101  95.577  133.615 1.00 77.45  ? 578 LYS A CD    1 
ATOM   3529  C  CE    . LYS A 1 586 ? 73.106  94.062  133.497 1.00 82.79  ? 578 LYS A CE    1 
ATOM   3530  N  NZ    . LYS A 1 586 ? 73.437  93.407  134.792 1.00 88.15  ? 578 LYS A NZ    1 
ATOM   3531  N  N     . SER A 1 587 ? 73.123  100.770 131.372 1.00 68.23  ? 579 SER A N     1 
ATOM   3532  C  CA    . SER A 1 587 ? 72.992  102.180 131.718 1.00 69.19  ? 579 SER A CA    1 
ATOM   3533  C  C     . SER A 1 587 ? 72.176  102.948 130.689 1.00 73.80  ? 579 SER A C     1 
ATOM   3534  O  O     . SER A 1 587 ? 71.453  103.882 131.052 1.00 76.09  ? 579 SER A O     1 
ATOM   3535  C  CB    . SER A 1 587 ? 74.373  102.813 131.875 1.00 63.00  ? 579 SER A CB    1 
ATOM   3536  O  OG    . SER A 1 587 ? 75.107  102.178 132.905 1.00 65.78  ? 579 SER A OG    1 
ATOM   3537  N  N     . VAL A 1 588 ? 72.284  102.591 129.407 1.00 72.58  ? 580 VAL A N     1 
ATOM   3538  C  CA    . VAL A 1 588 ? 71.490  103.286 128.395 1.00 73.20  ? 580 VAL A CA    1 
ATOM   3539  C  C     . VAL A 1 588 ? 70.005  103.029 128.618 1.00 77.39  ? 580 VAL A C     1 
ATOM   3540  O  O     . VAL A 1 588 ? 69.168  103.913 128.398 1.00 80.71  ? 580 VAL A O     1 
ATOM   3541  C  CB    . VAL A 1 588 ? 71.933  102.883 126.975 1.00 74.24  ? 580 VAL A CB    1 
ATOM   3542  C  CG1   . VAL A 1 588 ? 73.337  103.386 126.694 1.00 73.82  ? 580 VAL A CG1   1 
ATOM   3543  C  CG2   . VAL A 1 588 ? 71.858  101.381 126.787 1.00 74.63  ? 580 VAL A CG2   1 
ATOM   3544  N  N     . ILE A 1 589 ? 69.653  101.819 129.058 1.00 76.97  ? 581 ILE A N     1 
ATOM   3545  C  CA    . ILE A 1 589 ? 68.262  101.527 129.392 1.00 77.39  ? 581 ILE A CA    1 
ATOM   3546  C  C     . ILE A 1 589 ? 67.854  102.258 130.664 1.00 76.15  ? 581 ILE A C     1 
ATOM   3547  O  O     . ILE A 1 589 ? 66.752  102.815 130.750 1.00 76.70  ? 581 ILE A O     1 
ATOM   3548  C  CB    . ILE A 1 589 ? 68.051  100.008 129.522 1.00 75.21  ? 581 ILE A CB    1 
ATOM   3549  C  CG1   . ILE A 1 589 ? 68.316  99.313  128.187 1.00 76.14  ? 581 ILE A CG1   1 
ATOM   3550  C  CG2   . ILE A 1 589 ? 66.645  99.704  130.012 1.00 76.02  ? 581 ILE A CG2   1 
ATOM   3551  C  CD1   . ILE A 1 589 ? 68.094  97.818  128.225 1.00 77.67  ? 581 ILE A CD1   1 
ATOM   3552  N  N     . GLN A 1 590 ? 68.730  102.265 131.671 1.00 74.45  ? 582 GLN A N     1 
ATOM   3553  C  CA    . GLN A 1 590 ? 68.383  102.871 132.953 1.00 78.02  ? 582 GLN A CA    1 
ATOM   3554  C  C     . GLN A 1 590 ? 68.160  104.374 132.823 1.00 80.31  ? 582 GLN A C     1 
ATOM   3555  O  O     . GLN A 1 590 ? 67.210  104.918 133.397 1.00 84.61  ? 582 GLN A O     1 
ATOM   3556  C  CB    . GLN A 1 590 ? 69.475  102.578 133.982 1.00 78.38  ? 582 GLN A CB    1 
ATOM   3557  C  CG    . GLN A 1 590 ? 69.209  103.168 135.356 1.00 77.34  ? 582 GLN A CG    1 
ATOM   3558  C  CD    . GLN A 1 590 ? 70.323  102.874 136.341 1.00 82.61  ? 582 GLN A CD    1 
ATOM   3559  O  OE1   . GLN A 1 590 ? 71.243  102.110 136.046 1.00 84.62  ? 582 GLN A OE1   1 
ATOM   3560  N  NE2   . GLN A 1 590 ? 70.248  103.481 137.519 1.00 82.54  ? 582 GLN A NE2   1 
ATOM   3561  N  N     . LEU A 1 591 ? 69.020  105.062 132.074 1.00 77.10  ? 583 LEU A N     1 
ATOM   3562  C  CA    . LEU A 1 591 ? 68.918  106.508 131.931 1.00 79.34  ? 583 LEU A CA    1 
ATOM   3563  C  C     . LEU A 1 591 ? 68.050  106.938 130.757 1.00 85.07  ? 583 LEU A C     1 
ATOM   3564  O  O     . LEU A 1 591 ? 67.783  108.137 130.617 1.00 85.53  ? 583 LEU A O     1 
ATOM   3565  C  CB    . LEU A 1 591 ? 70.312  107.125 131.781 1.00 75.60  ? 583 LEU A CB    1 
ATOM   3566  C  CG    . LEU A 1 591 ? 71.256  106.959 132.971 1.00 69.71  ? 583 LEU A CG    1 
ATOM   3567  C  CD1   . LEU A 1 591 ? 72.542  107.736 132.747 1.00 65.28  ? 583 LEU A CD1   1 
ATOM   3568  C  CD2   . LEU A 1 591 ? 70.575  107.403 134.252 1.00 75.65  ? 583 LEU A CD2   1 
ATOM   3569  N  N     . ASP A 1 592 ? 67.609  106.000 129.921 1.00 84.42  ? 584 ASP A N     1 
ATOM   3570  C  CA    . ASP A 1 592 ? 66.740  106.283 128.779 1.00 87.99  ? 584 ASP A CA    1 
ATOM   3571  C  C     . ASP A 1 592 ? 67.353  107.351 127.872 1.00 90.20  ? 584 ASP A C     1 
ATOM   3572  O  O     . ASP A 1 592 ? 66.817  108.446 127.694 1.00 92.28  ? 584 ASP A O     1 
ATOM   3573  C  CB    . ASP A 1 592 ? 65.340  106.691 129.247 1.00 91.25  ? 584 ASP A CB    1 
ATOM   3574  C  CG    . ASP A 1 592 ? 64.334  106.737 128.112 1.00 96.33  ? 584 ASP A CG    1 
ATOM   3575  O  OD1   . ASP A 1 592 ? 64.656  106.255 127.007 1.00 95.60  ? 584 ASP A OD1   1 
ATOM   3576  O  OD2   . ASP A 1 592 ? 63.220  107.260 128.326 1.00 96.00  ? 584 ASP A OD2   1 
ATOM   3577  N  N     . LEU A 1 593 ? 68.509  107.012 127.300 1.00 88.96  ? 585 LEU A N     1 
ATOM   3578  C  CA    . LEU A 1 593 ? 69.182  107.921 126.381 1.00 87.43  ? 585 LEU A CA    1 
ATOM   3579  C  C     . LEU A 1 593 ? 68.513  107.987 125.017 1.00 85.78  ? 585 LEU A C     1 
ATOM   3580  O  O     . LEU A 1 593 ? 68.832  108.889 124.236 1.00 85.89  ? 585 LEU A O     1 
ATOM   3581  C  CB    . LEU A 1 593 ? 70.645  107.513 126.209 1.00 84.78  ? 585 LEU A CB    1 
ATOM   3582  C  CG    . LEU A 1 593 ? 71.679  108.357 126.950 1.00 83.35  ? 585 LEU A CG    1 
ATOM   3583  C  CD1   . LEU A 1 593 ? 71.470  108.269 128.451 1.00 79.49  ? 585 LEU A CD1   1 
ATOM   3584  C  CD2   . LEU A 1 593 ? 73.084  107.923 126.572 1.00 75.73  ? 585 LEU A CD2   1 
ATOM   3585  N  N     . ALA A 1 594 ? 67.609  107.056 124.708 1.00 85.81  ? 586 ALA A N     1 
ATOM   3586  C  CA    . ALA A 1 594 ? 66.957  107.063 123.403 1.00 89.04  ? 586 ALA A CA    1 
ATOM   3587  C  C     . ALA A 1 594 ? 66.073  108.291 123.225 1.00 91.10  ? 586 ALA A C     1 
ATOM   3588  O  O     . ALA A 1 594 ? 66.052  108.896 122.147 1.00 91.44  ? 586 ALA A O     1 
ATOM   3589  C  CB    . ALA A 1 594 ? 66.142  105.784 123.218 1.00 89.95  ? 586 ALA A CB    1 
ATOM   3590  N  N     . ASN A 1 595 ? 65.336  108.674 124.267 1.00 90.37  ? 587 ASN A N     1 
ATOM   3591  C  CA    . ASN A 1 595 ? 64.361  109.752 124.179 1.00 90.47  ? 587 ASN A CA    1 
ATOM   3592  C  C     . ASN A 1 595 ? 64.856  111.055 124.793 1.00 87.41  ? 587 ASN A C     1 
ATOM   3593  O  O     . ASN A 1 595 ? 64.093  112.023 124.862 1.00 88.39  ? 587 ASN A O     1 
ATOM   3594  C  CB    . ASN A 1 595 ? 63.051  109.326 124.844 1.00 94.31  ? 587 ASN A CB    1 
ATOM   3595  C  CG    . ASN A 1 595 ? 62.540  107.998 124.323 1.00 97.17  ? 587 ASN A CG    1 
ATOM   3596  O  OD1   . ASN A 1 595 ? 61.792  107.948 123.347 1.00 99.27  ? 587 ASN A OD1   1 
ATOM   3597  N  ND2   . ASN A 1 595 ? 62.942  106.913 124.973 1.00 94.20  ? 587 ASN A ND2   1 
ATOM   3598  N  N     . THR A 1 596 ? 66.108  111.107 125.241 1.00 85.93  ? 588 THR A N     1 
ATOM   3599  C  CA    . THR A 1 596 ? 66.647  112.300 125.877 1.00 83.59  ? 588 THR A CA    1 
ATOM   3600  C  C     . THR A 1 596 ? 68.037  112.586 125.329 1.00 81.58  ? 588 THR A C     1 
ATOM   3601  O  O     . THR A 1 596 ? 68.738  111.688 124.857 1.00 86.09  ? 588 THR A O     1 
ATOM   3602  C  CB    . THR A 1 596 ? 66.710  112.153 127.405 1.00 84.52  ? 588 THR A CB    1 
ATOM   3603  O  OG1   . THR A 1 596 ? 67.411  110.950 127.743 1.00 88.96  ? 588 THR A OG1   1 
ATOM   3604  C  CG2   . THR A 1 596 ? 65.311  112.107 128.002 1.00 84.21  ? 588 THR A CG2   1 
ATOM   3605  N  N     . LYS A 1 597 ? 68.427  113.860 125.396 1.00 75.09  ? 589 LYS A N     1 
ATOM   3606  C  CA    . LYS A 1 597 ? 69.766  114.285 124.987 1.00 72.56  ? 589 LYS A CA    1 
ATOM   3607  C  C     . LYS A 1 597 ? 70.679  114.254 126.208 1.00 70.03  ? 589 LYS A C     1 
ATOM   3608  O  O     . LYS A 1 597 ? 70.922  115.261 126.876 1.00 70.06  ? 589 LYS A O     1 
ATOM   3609  C  CB    . LYS A 1 597 ? 69.724  115.669 124.352 1.00 70.89  ? 589 LYS A CB    1 
ATOM   3610  C  CG    . LYS A 1 597 ? 69.096  115.715 122.972 1.00 73.83  ? 589 LYS A CG    1 
ATOM   3611  C  CD    . LYS A 1 597 ? 69.252  117.098 122.361 1.00 71.92  ? 589 LYS A CD    1 
ATOM   3612  C  CE    . LYS A 1 597 ? 68.702  117.148 120.947 1.00 79.16  ? 589 LYS A CE    1 
ATOM   3613  N  NZ    . LYS A 1 597 ? 68.900  118.489 120.331 1.00 81.59  ? 589 LYS A NZ    1 
ATOM   3614  N  N     . LYS A 1 598 ? 71.194  113.063 126.501 1.00 69.22  ? 590 LYS A N     1 
ATOM   3615  C  CA    . LYS A 1 598 ? 72.078  112.854 127.638 1.00 67.67  ? 590 LYS A CA    1 
ATOM   3616  C  C     . LYS A 1 598 ? 73.339  112.135 127.185 1.00 66.32  ? 590 LYS A C     1 
ATOM   3617  O  O     . LYS A 1 598 ? 73.278  111.197 126.386 1.00 66.86  ? 590 LYS A O     1 
ATOM   3618  C  CB    . LYS A 1 598 ? 71.386  112.047 128.742 1.00 68.04  ? 590 LYS A CB    1 
ATOM   3619  C  CG    . LYS A 1 598 ? 70.211  112.759 129.385 1.00 70.71  ? 590 LYS A CG    1 
ATOM   3620  C  CD    . LYS A 1 598 ? 69.575  111.904 130.466 1.00 75.53  ? 590 LYS A CD    1 
ATOM   3621  C  CE    . LYS A 1 598 ? 68.392  112.612 131.101 1.00 81.97  ? 590 LYS A CE    1 
ATOM   3622  N  NZ    . LYS A 1 598 ? 67.741  111.775 132.147 1.00 83.28  ? 590 LYS A NZ    1 
ATOM   3623  N  N     . ALA A 1 599 ? 74.478  112.584 127.701 1.00 60.94  ? 591 ALA A N     1 
ATOM   3624  C  CA    . ALA A 1 599 ? 75.771  111.969 127.434 1.00 54.49  ? 591 ALA A CA    1 
ATOM   3625  C  C     . ALA A 1 599 ? 76.282  111.351 128.727 1.00 55.95  ? 591 ALA A C     1 
ATOM   3626  O  O     . ALA A 1 599 ? 76.404  112.045 129.741 1.00 57.23  ? 591 ALA A O     1 
ATOM   3627  C  CB    . ALA A 1 599 ? 76.766  112.996 126.896 1.00 49.99  ? 591 ALA A CB    1 
ATOM   3628  N  N     . MET A 1 600 ? 76.580  110.054 128.693 1.00 55.61  ? 592 MET A N     1 
ATOM   3629  C  CA    . MET A 1 600 ? 77.024  109.339 129.886 1.00 53.71  ? 592 MET A CA    1 
ATOM   3630  C  C     . MET A 1 600 ? 78.542  109.443 129.985 1.00 54.10  ? 592 MET A C     1 
ATOM   3631  O  O     . MET A 1 600 ? 79.261  108.915 129.134 1.00 55.90  ? 592 MET A O     1 
ATOM   3632  C  CB    . MET A 1 600 ? 76.569  107.884 129.841 1.00 55.86  ? 592 MET A CB    1 
ATOM   3633  C  CG    . MET A 1 600 ? 75.074  107.719 129.651 1.00 57.78  ? 592 MET A CG    1 
ATOM   3634  S  SD    . MET A 1 600 ? 74.532  106.017 129.870 1.00 66.63  ? 592 MET A SD    1 
ATOM   3635  C  CE    . MET A 1 600 ? 75.681  105.166 128.797 1.00 55.33  ? 592 MET A CE    1 
ATOM   3636  N  N     . ILE A 1 601 ? 79.029  110.117 131.021 1.00 50.67  ? 593 ILE A N     1 
ATOM   3637  C  CA    . ILE A 1 601 ? 80.455  110.378 131.183 1.00 48.46  ? 593 ILE A CA    1 
ATOM   3638  C  C     . ILE A 1 601 ? 81.106  109.202 131.897 1.00 50.74  ? 593 ILE A C     1 
ATOM   3639  O  O     . ILE A 1 601 ? 80.599  108.724 132.918 1.00 53.50  ? 593 ILE A O     1 
ATOM   3640  C  CB    . ILE A 1 601 ? 80.690  111.684 131.958 1.00 45.60  ? 593 ILE A CB    1 
ATOM   3641  C  CG1   . ILE A 1 601 ? 80.255  112.886 131.124 1.00 47.45  ? 593 ILE A CG1   1 
ATOM   3642  C  CG2   . ILE A 1 601 ? 82.147  111.812 132.365 1.00 43.80  ? 593 ILE A CG2   1 
ATOM   3643  C  CD1   . ILE A 1 601 ? 80.446  114.206 131.831 1.00 52.60  ? 593 ILE A CD1   1 
ATOM   3644  N  N     . VAL A 1 602 ? 82.226  108.734 131.360 1.00 49.90  ? 594 VAL A N     1 
ATOM   3645  C  CA    . VAL A 1 602 ? 83.035  107.693 131.987 1.00 51.94  ? 594 VAL A CA    1 
ATOM   3646  C  C     . VAL A 1 602 ? 84.251  108.363 132.618 1.00 57.11  ? 594 VAL A C     1 
ATOM   3647  O  O     . VAL A 1 602 ? 85.023  109.015 131.898 1.00 55.98  ? 594 VAL A O     1 
ATOM   3648  C  CB    . VAL A 1 602 ? 83.461  106.619 130.976 1.00 46.88  ? 594 VAL A CB    1 
ATOM   3649  C  CG1   . VAL A 1 602 ? 84.444  105.656 131.612 1.00 48.71  ? 594 VAL A CG1   1 
ATOM   3650  C  CG2   . VAL A 1 602 ? 82.244  105.870 130.459 1.00 45.33  ? 594 VAL A CG2   1 
ATOM   3651  N  N     . PRO A 1 603 ? 84.446  108.256 133.932 1.00 56.09  ? 595 PRO A N     1 
ATOM   3652  C  CA    . PRO A 1 603 ? 85.593  108.918 134.567 1.00 53.30  ? 595 PRO A CA    1 
ATOM   3653  C  C     . PRO A 1 603 ? 86.918  108.422 134.006 1.00 54.76  ? 595 PRO A C     1 
ATOM   3654  O  O     . PRO A 1 603 ? 87.082  107.240 133.697 1.00 51.56  ? 595 PRO A O     1 
ATOM   3655  C  CB    . PRO A 1 603 ? 85.436  108.549 136.046 1.00 54.12  ? 595 PRO A CB    1 
ATOM   3656  C  CG    . PRO A 1 603 ? 83.981  108.271 136.208 1.00 51.01  ? 595 PRO A CG    1 
ATOM   3657  C  CD    . PRO A 1 603 ? 83.536  107.653 134.919 1.00 51.03  ? 595 PRO A CD    1 
ATOM   3658  N  N     . ALA A 1 604 ? 87.869  109.343 133.883 1.00 57.35  ? 596 ALA A N     1 
ATOM   3659  C  CA    . ALA A 1 604 ? 89.162  109.073 133.271 1.00 55.74  ? 596 ALA A CA    1 
ATOM   3660  C  C     . ALA A 1 604 ? 90.266  109.173 134.312 1.00 61.56  ? 596 ALA A C     1 
ATOM   3661  O  O     . ALA A 1 604 ? 90.347  110.161 135.049 1.00 64.83  ? 596 ALA A O     1 
ATOM   3662  C  CB    . ALA A 1 604 ? 89.437  110.047 132.124 1.00 54.05  ? 596 ALA A CB    1 
ATOM   3663  N  N     . PHE A 1 605 ? 91.117  108.153 134.359 1.00 61.55  ? 597 PHE A N     1 
ATOM   3664  C  CA    . PHE A 1 605 ? 92.271  108.116 135.240 1.00 61.18  ? 597 PHE A CA    1 
ATOM   3665  C  C     . PHE A 1 605 ? 93.526  107.870 134.416 1.00 63.05  ? 597 PHE A C     1 
ATOM   3666  O  O     . PHE A 1 605 ? 93.461  107.408 133.274 1.00 65.41  ? 597 PHE A O     1 
ATOM   3667  C  CB    . PHE A 1 605 ? 92.122  107.029 136.311 1.00 58.63  ? 597 PHE A CB    1 
ATOM   3668  C  CG    . PHE A 1 605 ? 90.910  107.199 137.175 1.00 60.88  ? 597 PHE A CG    1 
ATOM   3669  C  CD1   . PHE A 1 605 ? 90.921  108.088 138.235 1.00 64.63  ? 597 PHE A CD1   1 
ATOM   3670  C  CD2   . PHE A 1 605 ? 89.760  106.475 136.926 1.00 58.21  ? 597 PHE A CD2   1 
ATOM   3671  C  CE1   . PHE A 1 605 ? 89.810  108.249 139.031 1.00 64.13  ? 597 PHE A CE1   1 
ATOM   3672  C  CE2   . PHE A 1 605 ? 88.645  106.634 137.719 1.00 57.59  ? 597 PHE A CE2   1 
ATOM   3673  C  CZ    . PHE A 1 605 ? 88.671  107.522 138.772 1.00 63.23  ? 597 PHE A CZ    1 
ATOM   3674  N  N     . GLU A 1 606 ? 94.675  108.190 135.001 1.00 68.01  ? 598 GLU A N     1 
ATOM   3675  C  CA    . GLU A 1 606 ? 95.950  108.023 134.325 1.00 67.85  ? 598 GLU A CA    1 
ATOM   3676  C  C     . GLU A 1 606 ? 96.954  107.368 135.261 1.00 72.54  ? 598 GLU A C     1 
ATOM   3677  O  O     . GLU A 1 606 ? 96.846  107.458 136.486 1.00 78.01  ? 598 GLU A O     1 
ATOM   3678  C  CB    . GLU A 1 606 ? 96.503  109.360 133.820 1.00 69.41  ? 598 GLU A CB    1 
ATOM   3679  C  CG    . GLU A 1 606 ? 96.819  110.355 134.916 1.00 78.18  ? 598 GLU A CG    1 
ATOM   3680  C  CD    . GLU A 1 606 ? 97.409  111.640 134.376 1.00 83.93  ? 598 GLU A CD    1 
ATOM   3681  O  OE1   . GLU A 1 606 ? 97.623  111.725 133.148 1.00 81.11  ? 598 GLU A OE1   1 
ATOM   3682  O  OE2   . GLU A 1 606 ? 97.657  112.565 135.177 1.00 88.46  ? 598 GLU A OE2   1 
ATOM   3683  N  N     . THR A 1 607 ? 97.934  106.699 134.660 1.00 72.16  ? 599 THR A N     1 
ATOM   3684  C  CA    . THR A 1 607 ? 99.013  106.059 135.393 1.00 71.92  ? 599 THR A CA    1 
ATOM   3685  C  C     . THR A 1 607 ? 100.321 106.331 134.669 1.00 75.54  ? 599 THR A C     1 
ATOM   3686  O  O     . THR A 1 607 ? 100.339 106.677 133.486 1.00 78.06  ? 599 THR A O     1 
ATOM   3687  C  CB    . THR A 1 607 ? 98.792  104.548 135.536 1.00 70.91  ? 599 THR A CB    1 
ATOM   3688  O  OG1   . THR A 1 607 ? 99.864  103.978 136.297 1.00 79.50  ? 599 THR A OG1   1 
ATOM   3689  C  CG2   . THR A 1 607 ? 98.741  103.883 134.172 1.00 69.46  ? 599 THR A CG2   1 
ATOM   3690  N  N     . LEU A 1 608 ? 101.423 106.186 135.399 1.00 78.66  ? 600 LEU A N     1 
ATOM   3691  C  CA    . LEU A 1 608 ? 102.749 106.383 134.837 1.00 75.96  ? 600 LEU A CA    1 
ATOM   3692  C  C     . LEU A 1 608 ? 103.561 105.099 134.769 1.00 75.98  ? 600 LEU A C     1 
ATOM   3693  O  O     . LEU A 1 608 ? 104.676 105.114 134.240 1.00 78.51  ? 600 LEU A O     1 
ATOM   3694  C  CB    . LEU A 1 608 ? 103.512 107.439 135.643 1.00 78.39  ? 600 LEU A CB    1 
ATOM   3695  C  CG    . LEU A 1 608 ? 102.812 108.795 135.759 1.00 81.57  ? 600 LEU A CG    1 
ATOM   3696  C  CD1   . LEU A 1 608 ? 103.671 109.784 136.532 1.00 79.53  ? 600 LEU A CD1   1 
ATOM   3697  C  CD2   . LEU A 1 608 ? 102.470 109.339 134.382 1.00 80.39  ? 600 LEU A CD2   1 
ATOM   3698  N  N     . ARG A 1 609 ? 103.032 103.989 135.273 1.00 78.91  ? 601 ARG A N     1 
ATOM   3699  C  CA    . ARG A 1 609 ? 103.739 102.715 135.282 1.00 83.47  ? 601 ARG A CA    1 
ATOM   3700  C  C     . ARG A 1 609 ? 103.162 101.818 134.195 1.00 80.17  ? 601 ARG A C     1 
ATOM   3701  O  O     . ARG A 1 609 ? 101.953 101.565 134.170 1.00 81.18  ? 601 ARG A O     1 
ATOM   3702  C  CB    . ARG A 1 609 ? 103.630 102.043 136.650 1.00 84.27  ? 601 ARG A CB    1 
ATOM   3703  C  CG    . ARG A 1 609 ? 104.170 102.887 137.792 1.00 85.35  ? 601 ARG A CG    1 
ATOM   3704  C  CD    . ARG A 1 609 ? 103.919 102.229 139.138 1.00 92.43  ? 601 ARG A CD    1 
ATOM   3705  N  NE    . ARG A 1 609 ? 104.351 103.076 140.242 1.00 98.55  ? 601 ARG A NE    1 
ATOM   3706  C  CZ    . ARG A 1 609 ? 104.191 102.776 141.524 1.00 100.25 ? 601 ARG A CZ    1 
ATOM   3707  N  NH1   . ARG A 1 609 ? 103.608 101.650 141.902 1.00 101.31 ? 601 ARG A NH1   1 
ATOM   3708  N  NH2   . ARG A 1 609 ? 104.626 103.627 142.449 1.00 101.65 ? 601 ARG A NH2   1 
ATOM   3709  N  N     . TYR A 1 610 ? 104.029 101.343 133.298 1.00 79.33  ? 602 TYR A N     1 
ATOM   3710  C  CA    . TYR A 1 610 ? 103.575 100.461 132.228 1.00 83.07  ? 602 TYR A CA    1 
ATOM   3711  C  C     . TYR A 1 610 ? 103.044 99.146  132.782 1.00 84.39  ? 602 TYR A C     1 
ATOM   3712  O  O     . TYR A 1 610 ? 101.998 98.656  132.342 1.00 82.87  ? 602 TYR A O     1 
ATOM   3713  C  CB    . TYR A 1 610 ? 104.712 100.211 131.239 1.00 86.69  ? 602 TYR A CB    1 
ATOM   3714  C  CG    . TYR A 1 610 ? 105.081 101.428 130.425 1.00 91.89  ? 602 TYR A CG    1 
ATOM   3715  C  CD1   . TYR A 1 610 ? 105.948 102.389 130.929 1.00 89.80  ? 602 TYR A CD1   1 
ATOM   3716  C  CD2   . TYR A 1 610 ? 104.559 101.619 129.153 1.00 97.18  ? 602 TYR A CD2   1 
ATOM   3717  C  CE1   . TYR A 1 610 ? 106.285 103.504 130.187 1.00 91.82  ? 602 TYR A CE1   1 
ATOM   3718  C  CE2   . TYR A 1 610 ? 104.891 102.730 128.405 1.00 97.33  ? 602 TYR A CE2   1 
ATOM   3719  C  CZ    . TYR A 1 610 ? 105.753 103.668 128.927 1.00 95.84  ? 602 TYR A CZ    1 
ATOM   3720  O  OH    . TYR A 1 610 ? 106.086 104.773 128.183 1.00 89.78  ? 602 TYR A OH    1 
ATOM   3721  N  N     . ARG A 1 611 ? 103.747 98.562  133.749 1.00 89.05  ? 603 ARG A N     1 
ATOM   3722  C  CA    . ARG A 1 611 ? 103.276 97.348  134.407 1.00 90.81  ? 603 ARG A CA    1 
ATOM   3723  C  C     . ARG A 1 611 ? 102.216 97.736  135.428 1.00 87.26  ? 603 ARG A C     1 
ATOM   3724  O  O     . ARG A 1 611 ? 102.524 98.361  136.448 1.00 88.43  ? 603 ARG A O     1 
ATOM   3725  C  CB    . ARG A 1 611 ? 104.432 96.604  135.067 1.00 94.48  ? 603 ARG A CB    1 
ATOM   3726  C  CG    . ARG A 1 611 ? 105.291 95.808  134.099 1.00 98.90  ? 603 ARG A CG    1 
ATOM   3727  C  CD    . ARG A 1 611 ? 106.239 94.882  134.843 1.00 107.77 ? 603 ARG A CD    1 
ATOM   3728  N  NE    . ARG A 1 611 ? 106.899 93.942  133.945 1.00 115.31 ? 603 ARG A NE    1 
ATOM   3729  C  CZ    . ARG A 1 611 ? 107.713 92.974  134.343 1.00 119.83 ? 603 ARG A CZ    1 
ATOM   3730  N  NH1   . ARG A 1 611 ? 107.996 92.790  135.622 1.00 123.48 ? 603 ARG A NH1   1 
ATOM   3731  N  NH2   . ARG A 1 611 ? 108.255 92.168  133.433 1.00 114.80 ? 603 ARG A NH2   1 
ATOM   3732  N  N     . LEU A 1 612 ? 100.967 97.373  135.154 1.00 85.17  ? 604 LEU A N     1 
ATOM   3733  C  CA    . LEU A 1 612 ? 99.843  97.753  135.996 1.00 83.63  ? 604 LEU A CA    1 
ATOM   3734  C  C     . LEU A 1 612 ? 98.963  96.540  136.248 1.00 83.05  ? 604 LEU A C     1 
ATOM   3735  O  O     . LEU A 1 612 ? 98.613  95.817  135.310 1.00 83.88  ? 604 LEU A O     1 
ATOM   3736  C  CB    . LEU A 1 612 ? 99.026  98.872  135.345 1.00 80.71  ? 604 LEU A CB    1 
ATOM   3737  C  CG    . LEU A 1 612 ? 97.883  99.439  136.184 1.00 80.32  ? 604 LEU A CG    1 
ATOM   3738  C  CD1   . LEU A 1 612 ? 98.435  100.056 137.454 1.00 85.94  ? 604 LEU A CD1   1 
ATOM   3739  C  CD2   . LEU A 1 612 ? 97.086  100.459 135.389 1.00 72.75  ? 604 LEU A CD2   1 
ATOM   3740  N  N     . SER A 1 613 ? 98.610  96.320  137.511 1.00 79.68  ? 605 SER A N     1 
ATOM   3741  C  CA    . SER A 1 613 ? 97.628  95.303  137.879 1.00 79.31  ? 605 SER A CA    1 
ATOM   3742  C  C     . SER A 1 613 ? 96.255  95.954  137.789 1.00 78.97  ? 605 SER A C     1 
ATOM   3743  O  O     . SER A 1 613 ? 95.858  96.719  138.671 1.00 80.41  ? 605 SER A O     1 
ATOM   3744  C  CB    . SER A 1 613 ? 97.905  94.756  139.274 1.00 80.71  ? 605 SER A CB    1 
ATOM   3745  O  OG    . SER A 1 613 ? 96.926  93.802  139.646 1.00 77.73  ? 605 SER A OG    1 
ATOM   3746  N  N     . PHE A 1 614 ? 95.530  95.655  136.720 1.00 74.46  ? 606 PHE A N     1 
ATOM   3747  C  CA    . PHE A 1 614 ? 94.271  96.339  136.465 1.00 72.60  ? 606 PHE A CA    1 
ATOM   3748  C  C     . PHE A 1 614 ? 93.229  95.924  137.498 1.00 73.04  ? 606 PHE A C     1 
ATOM   3749  O  O     . PHE A 1 614 ? 92.982  94.725  137.675 1.00 74.54  ? 606 PHE A O     1 
ATOM   3750  C  CB    . PHE A 1 614 ? 93.774  96.033  135.055 1.00 71.33  ? 606 PHE A CB    1 
ATOM   3751  C  CG    . PHE A 1 614 ? 93.004  97.159  134.431 1.00 65.89  ? 606 PHE A CG    1 
ATOM   3752  C  CD1   . PHE A 1 614 ? 93.666  98.199  133.801 1.00 64.09  ? 606 PHE A CD1   1 
ATOM   3753  C  CD2   . PHE A 1 614 ? 91.622  97.180  134.476 1.00 62.37  ? 606 PHE A CD2   1 
ATOM   3754  C  CE1   . PHE A 1 614 ? 92.965  99.237  133.228 1.00 60.66  ? 606 PHE A CE1   1 
ATOM   3755  C  CE2   . PHE A 1 614 ? 90.915  98.217  133.904 1.00 62.47  ? 606 PHE A CE2   1 
ATOM   3756  C  CZ    . PHE A 1 614 ? 91.588  99.247  133.280 1.00 60.36  ? 606 PHE A CZ    1 
ATOM   3757  N  N     . PRO A 1 615 ? 92.608  96.872  138.197 1.00 69.45  ? 607 PRO A N     1 
ATOM   3758  C  CA    . PRO A 1 615 ? 91.626  96.510  139.224 1.00 70.16  ? 607 PRO A CA    1 
ATOM   3759  C  C     . PRO A 1 615 ? 90.409  95.825  138.624 1.00 71.85  ? 607 PRO A C     1 
ATOM   3760  O  O     . PRO A 1 615 ? 90.008  96.097  137.491 1.00 74.82  ? 607 PRO A O     1 
ATOM   3761  C  CB    . PRO A 1 615 ? 91.256  97.858  139.850 1.00 70.69  ? 607 PRO A CB    1 
ATOM   3762  C  CG    . PRO A 1 615 ? 91.566  98.860  138.789 1.00 65.65  ? 607 PRO A CG    1 
ATOM   3763  C  CD    . PRO A 1 615 ? 92.768  98.330  138.072 1.00 64.36  ? 607 PRO A CD    1 
ATOM   3764  N  N     . LYS A 1 616 ? 89.823  94.921  139.405 1.00 72.00  ? 608 LYS A N     1 
ATOM   3765  C  CA    . LYS A 1 616 ? 88.615  94.210  139.013 1.00 74.71  ? 608 LYS A CA    1 
ATOM   3766  C  C     . LYS A 1 616 ? 87.365  94.771  139.678 1.00 73.05  ? 608 LYS A C     1 
ATOM   3767  O  O     . LYS A 1 616 ? 86.282  94.199  139.522 1.00 73.97  ? 608 LYS A O     1 
ATOM   3768  C  CB    . LYS A 1 616 ? 88.754  92.722  139.332 1.00 75.18  ? 608 LYS A CB    1 
ATOM   3769  C  CG    . LYS A 1 616 ? 89.918  92.047  138.629 1.00 74.92  ? 608 LYS A CG    1 
ATOM   3770  C  CD    . LYS A 1 616 ? 89.977  90.565  138.960 1.00 78.54  ? 608 LYS A CD    1 
ATOM   3771  C  CE    . LYS A 1 616 ? 91.120  89.882  138.229 1.00 81.50  ? 608 LYS A CE    1 
ATOM   3772  N  NZ    . LYS A 1 616 ? 91.166  88.421  138.515 1.00 85.18  ? 608 LYS A NZ    1 
ATOM   3773  N  N     . SER A 1 617 ? 87.489  95.871  140.416 1.00 70.17  ? 609 SER A N     1 
ATOM   3774  C  CA    . SER A 1 617 ? 86.353  96.473  141.098 1.00 72.91  ? 609 SER A CA    1 
ATOM   3775  C  C     . SER A 1 617 ? 86.678  97.931  141.387 1.00 73.00  ? 609 SER A C     1 
ATOM   3776  O  O     . SER A 1 617 ? 87.830  98.362  141.298 1.00 74.13  ? 609 SER A O     1 
ATOM   3777  C  CB    . SER A 1 617 ? 86.011  95.718  142.387 1.00 76.97  ? 609 SER A CB    1 
ATOM   3778  O  OG    . SER A 1 617 ? 87.117  95.694  143.272 1.00 81.64  ? 609 SER A OG    1 
ATOM   3779  N  N     . LYS A 1 618 ? 85.636  98.692  141.729 1.00 69.04  ? 610 LYS A N     1 
ATOM   3780  C  CA    . LYS A 1 618 ? 85.828  100.101 142.052 1.00 69.73  ? 610 LYS A CA    1 
ATOM   3781  C  C     . LYS A 1 618 ? 86.593  100.281 143.358 1.00 79.02  ? 610 LYS A C     1 
ATOM   3782  O  O     . LYS A 1 618 ? 87.369  101.234 143.493 1.00 80.87  ? 610 LYS A O     1 
ATOM   3783  C  CB    . LYS A 1 618 ? 84.477  100.813 142.125 1.00 66.35  ? 610 LYS A CB    1 
ATOM   3784  C  CG    . LYS A 1 618 ? 84.581  102.314 142.341 1.00 65.64  ? 610 LYS A CG    1 
ATOM   3785  C  CD    . LYS A 1 618 ? 83.211  102.969 142.398 1.00 62.91  ? 610 LYS A CD    1 
ATOM   3786  C  CE    . LYS A 1 618 ? 83.333  104.471 142.592 1.00 63.09  ? 610 LYS A CE    1 
ATOM   3787  N  NZ    . LYS A 1 618 ? 82.004  105.133 142.668 1.00 64.70  ? 610 LYS A NZ    1 
ATOM   3788  N  N     . ALA A 1 619 ? 86.385  99.385  144.327 1.00 77.39  ? 611 ALA A N     1 
ATOM   3789  C  CA    . ALA A 1 619 ? 87.079  99.500  145.606 1.00 75.85  ? 611 ALA A CA    1 
ATOM   3790  C  C     . ALA A 1 619 ? 88.587  99.374  145.431 1.00 75.97  ? 611 ALA A C     1 
ATOM   3791  O  O     . ALA A 1 619 ? 89.357  100.113 146.056 1.00 78.18  ? 611 ALA A O     1 
ATOM   3792  C  CB    . ALA A 1 619 ? 86.561  98.443  146.580 1.00 79.27  ? 611 ALA A CB    1 
ATOM   3793  N  N     . GLU A 1 620 ? 89.027  98.441  144.584 1.00 75.88  ? 612 GLU A N     1 
ATOM   3794  C  CA    . GLU A 1 620 ? 90.455  98.304  144.321 1.00 76.24  ? 612 GLU A CA    1 
ATOM   3795  C  C     . GLU A 1 620 ? 91.007  99.547  143.634 1.00 76.07  ? 612 GLU A C     1 
ATOM   3796  O  O     . GLU A 1 620 ? 92.133  99.972  143.915 1.00 76.91  ? 612 GLU A O     1 
ATOM   3797  C  CB    . GLU A 1 620 ? 90.717  97.057  143.478 1.00 74.75  ? 612 GLU A CB    1 
ATOM   3798  C  CG    . GLU A 1 620 ? 92.190  96.772  143.242 1.00 80.96  ? 612 GLU A CG    1 
ATOM   3799  C  CD    . GLU A 1 620 ? 92.420  95.461  142.519 1.00 92.63  ? 612 GLU A CD    1 
ATOM   3800  O  OE1   . GLU A 1 620 ? 91.438  94.721  142.301 1.00 94.69  ? 612 GLU A OE1   1 
ATOM   3801  O  OE2   . GLU A 1 620 ? 93.583  95.172  142.168 1.00 92.47  ? 612 GLU A OE2   1 
ATOM   3802  N  N     . LEU A 1 621 ? 90.227  100.143 142.728 1.00 73.02  ? 613 LEU A N     1 
ATOM   3803  C  CA    . LEU A 1 621 ? 90.652  101.385 142.089 1.00 72.65  ? 613 LEU A CA    1 
ATOM   3804  C  C     . LEU A 1 621 ? 90.809  102.504 143.109 1.00 76.16  ? 613 LEU A C     1 
ATOM   3805  O  O     . LEU A 1 621 ? 91.773  103.276 143.051 1.00 79.28  ? 613 LEU A O     1 
ATOM   3806  C  CB    . LEU A 1 621 ? 89.651  101.786 141.007 1.00 72.98  ? 613 LEU A CB    1 
ATOM   3807  C  CG    . LEU A 1 621 ? 89.769  103.216 140.475 1.00 68.24  ? 613 LEU A CG    1 
ATOM   3808  C  CD1   . LEU A 1 621 ? 91.087  103.425 139.753 1.00 67.44  ? 613 LEU A CD1   1 
ATOM   3809  C  CD2   . LEU A 1 621 ? 88.603  103.539 139.565 1.00 61.03  ? 613 LEU A CD2   1 
ATOM   3810  N  N     . LEU A 1 622 ? 89.867  102.610 144.048 1.00 74.42  ? 614 LEU A N     1 
ATOM   3811  C  CA    . LEU A 1 622 ? 89.982  103.618 145.097 1.00 73.48  ? 614 LEU A CA    1 
ATOM   3812  C  C     . LEU A 1 622 ? 91.209  103.368 145.964 1.00 79.43  ? 614 LEU A C     1 
ATOM   3813  O  O     . LEU A 1 622 ? 91.915  104.311 146.343 1.00 82.72  ? 614 LEU A O     1 
ATOM   3814  C  CB    . LEU A 1 622 ? 88.714  103.633 145.950 1.00 74.89  ? 614 LEU A CB    1 
ATOM   3815  C  CG    . LEU A 1 622 ? 87.425  104.020 145.226 1.00 76.91  ? 614 LEU A CG    1 
ATOM   3816  C  CD1   . LEU A 1 622 ? 86.235  103.928 146.167 1.00 80.82  ? 614 LEU A CD1   1 
ATOM   3817  C  CD2   . LEU A 1 622 ? 87.543  105.417 144.641 1.00 75.02  ? 614 LEU A CD2   1 
ATOM   3818  N  N     . SER A 1 623 ? 91.475  102.102 146.290 1.00 79.39  ? 615 SER A N     1 
ATOM   3819  C  CA    . SER A 1 623 ? 92.663  101.774 147.072 1.00 77.93  ? 615 SER A CA    1 
ATOM   3820  C  C     . SER A 1 623 ? 93.935  102.167 146.331 1.00 81.80  ? 615 SER A C     1 
ATOM   3821  O  O     . SER A 1 623 ? 94.869  102.711 146.931 1.00 83.48  ? 615 SER A O     1 
ATOM   3822  C  CB    . SER A 1 623 ? 92.676  100.283 147.406 1.00 77.00  ? 615 SER A CB    1 
ATOM   3823  O  OG    . SER A 1 623 ? 93.833  99.938  148.146 1.00 80.00  ? 615 SER A OG    1 
ATOM   3824  N  N     . MET A 1 624 ? 93.989  101.897 145.026 1.00 82.30  ? 616 MET A N     1 
ATOM   3825  C  CA    . MET A 1 624 ? 95.157  102.276 144.235 1.00 81.56  ? 616 MET A CA    1 
ATOM   3826  C  C     . MET A 1 624 ? 95.303  103.790 144.155 1.00 79.59  ? 616 MET A C     1 
ATOM   3827  O  O     . MET A 1 624 ? 96.424  104.311 144.139 1.00 82.04  ? 616 MET A O     1 
ATOM   3828  C  CB    . MET A 1 624 ? 95.065  101.667 142.837 1.00 76.28  ? 616 MET A CB    1 
ATOM   3829  C  CG    . MET A 1 624 ? 95.073  100.149 142.828 1.00 77.60  ? 616 MET A CG    1 
ATOM   3830  S  SD    . MET A 1 624 ? 95.144  99.460  141.168 1.00 78.32  ? 616 MET A SD    1 
ATOM   3831  C  CE    . MET A 1 624 ? 96.742  100.064 140.637 1.00 73.85  ? 616 MET A CE    1 
ATOM   3832  N  N     . LEU A 1 625 ? 94.181  104.511 144.090 1.00 79.07  ? 617 LEU A N     1 
ATOM   3833  C  CA    . LEU A 1 625 ? 94.235  105.969 144.139 1.00 82.09  ? 617 LEU A CA    1 
ATOM   3834  C  C     . LEU A 1 625 ? 94.796  106.452 145.469 1.00 88.74  ? 617 LEU A C     1 
ATOM   3835  O  O     . LEU A 1 625 ? 95.571  107.415 145.511 1.00 92.69  ? 617 LEU A O     1 
ATOM   3836  C  CB    . LEU A 1 625 ? 92.844  106.558 143.906 1.00 81.80  ? 617 LEU A CB    1 
ATOM   3837  C  CG    . LEU A 1 625 ? 92.346  106.652 142.466 1.00 79.76  ? 617 LEU A CG    1 
ATOM   3838  C  CD1   . LEU A 1 625 ? 90.914  107.151 142.443 1.00 77.00  ? 617 LEU A CD1   1 
ATOM   3839  C  CD2   . LEU A 1 625 ? 93.244  107.567 141.653 1.00 78.07  ? 617 LEU A CD2   1 
ATOM   3840  N  N     . ASP A 1 626 ? 94.407  105.801 146.567 1.00 88.89  ? 618 ASP A N     1 
ATOM   3841  C  CA    . ASP A 1 626 ? 94.896  106.204 147.882 1.00 88.52  ? 618 ASP A CA    1 
ATOM   3842  C  C     . ASP A 1 626 ? 96.394  105.968 148.027 1.00 90.97  ? 618 ASP A C     1 
ATOM   3843  O  O     . ASP A 1 626 ? 97.077  106.744 148.706 1.00 92.97  ? 618 ASP A O     1 
ATOM   3844  C  CB    . ASP A 1 626 ? 94.136  105.456 148.977 1.00 90.82  ? 618 ASP A CB    1 
ATOM   3845  C  CG    . ASP A 1 626 ? 92.653  105.765 148.972 1.00 90.62  ? 618 ASP A CG    1 
ATOM   3846  O  OD1   . ASP A 1 626 ? 92.282  106.892 148.581 1.00 90.40  ? 618 ASP A OD1   1 
ATOM   3847  O  OD2   . ASP A 1 626 ? 91.859  104.882 149.358 1.00 90.26  ? 618 ASP A OD2   1 
ATOM   3848  N  N     . MET A 1 627 ? 96.922  104.917 147.403 1.00 88.96  ? 619 MET A N     1 
ATOM   3849  C  CA    . MET A 1 627 ? 98.337  104.590 147.517 1.00 88.39  ? 619 MET A CA    1 
ATOM   3850  C  C     . MET A 1 627 ? 99.215  105.394 146.569 1.00 89.24  ? 619 MET A C     1 
ATOM   3851  O  O     . MET A 1 627 ? 100.441 105.249 146.616 1.00 91.41  ? 619 MET A O     1 
ATOM   3852  C  CB    . MET A 1 627 ? 98.553  103.094 147.270 1.00 91.56  ? 619 MET A CB    1 
ATOM   3853  C  CG    . MET A 1 627 ? 97.828  102.193 148.256 1.00 95.02  ? 619 MET A CG    1 
ATOM   3854  S  SD    . MET A 1 627 ? 98.161  100.443 147.975 1.00 120.94 ? 619 MET A SD    1 
ATOM   3855  C  CE    . MET A 1 627 ? 97.603  100.258 146.283 1.00 93.29  ? 619 MET A CE    1 
ATOM   3856  N  N     . GLY A 1 628 ? 98.629  106.229 145.715 1.00 88.35  ? 620 GLY A N     1 
ATOM   3857  C  CA    . GLY A 1 628 ? 99.402  107.035 144.794 1.00 87.05  ? 620 GLY A CA    1 
ATOM   3858  C  C     . GLY A 1 628 ? 99.826  106.338 143.522 1.00 89.75  ? 620 GLY A C     1 
ATOM   3859  O  O     . GLY A 1 628 ? 100.560 106.933 142.726 1.00 88.58  ? 620 GLY A O     1 
ATOM   3860  N  N     . THR A 1 629 ? 99.397  105.093 143.306 1.00 89.58  ? 621 THR A N     1 
ATOM   3861  C  CA    . THR A 1 629 ? 99.751  104.397 142.073 1.00 87.03  ? 621 THR A CA    1 
ATOM   3862  C  C     . THR A 1 629 ? 99.021  104.988 140.873 1.00 87.36  ? 621 THR A C     1 
ATOM   3863  O  O     . THR A 1 629 ? 99.605  105.133 139.794 1.00 86.98  ? 621 THR A O     1 
ATOM   3864  C  CB    . THR A 1 629 ? 99.443  102.907 142.203 1.00 87.18  ? 621 THR A CB    1 
ATOM   3865  O  OG1   . THR A 1 629 ? 98.063  102.732 142.543 1.00 86.14  ? 621 THR A OG1   1 
ATOM   3866  C  CG2   . THR A 1 629 ? 100.310 102.278 143.283 1.00 90.05  ? 621 THR A CG2   1 
ATOM   3867  N  N     . LEU A 1 630 ? 97.749  105.338 141.042 1.00 87.27  ? 622 LEU A N     1 
ATOM   3868  C  CA    . LEU A 1 630 ? 96.941  105.904 139.976 1.00 82.74  ? 622 LEU A CA    1 
ATOM   3869  C  C     . LEU A 1 630 ? 96.532  107.325 140.335 1.00 82.91  ? 622 LEU A C     1 
ATOM   3870  O  O     . LEU A 1 630 ? 96.514  107.716 141.505 1.00 85.06  ? 622 LEU A O     1 
ATOM   3871  C  CB    . LEU A 1 630 ? 95.687  105.061 139.707 1.00 78.87  ? 622 LEU A CB    1 
ATOM   3872  C  CG    . LEU A 1 630 ? 95.885  103.571 139.426 1.00 81.44  ? 622 LEU A CG    1 
ATOM   3873  C  CD1   . LEU A 1 630 ? 94.582  102.935 138.976 1.00 68.25  ? 622 LEU A CD1   1 
ATOM   3874  C  CD2   . LEU A 1 630 ? 96.971  103.353 138.392 1.00 80.76  ? 622 LEU A CD2   1 
ATOM   3875  N  N     . PHE A 1 631 ? 96.203  108.098 139.304 1.00 78.54  ? 623 PHE A N     1 
ATOM   3876  C  CA    . PHE A 1 631 ? 95.753  109.469 139.472 1.00 80.39  ? 623 PHE A CA    1 
ATOM   3877  C  C     . PHE A 1 631 ? 94.599  109.728 138.517 1.00 77.69  ? 623 PHE A C     1 
ATOM   3878  O  O     . PHE A 1 631 ? 94.402  109.002 137.539 1.00 77.95  ? 623 PHE A O     1 
ATOM   3879  C  CB    . PHE A 1 631 ? 96.879  110.477 139.209 1.00 83.25  ? 623 PHE A CB    1 
ATOM   3880  C  CG    . PHE A 1 631 ? 98.113  110.239 140.029 1.00 87.25  ? 623 PHE A CG    1 
ATOM   3881  C  CD1   . PHE A 1 631 ? 98.255  110.824 141.276 1.00 87.46  ? 623 PHE A CD1   1 
ATOM   3882  C  CD2   . PHE A 1 631 ? 99.136  109.440 139.549 1.00 88.29  ? 623 PHE A CD2   1 
ATOM   3883  C  CE1   . PHE A 1 631 ? 99.391  110.611 142.031 1.00 89.60  ? 623 PHE A CE1   1 
ATOM   3884  C  CE2   . PHE A 1 631 ? 100.275 109.223 140.300 1.00 89.52  ? 623 PHE A CE2   1 
ATOM   3885  C  CZ    . PHE A 1 631 ? 100.403 109.810 141.542 1.00 87.98  ? 623 PHE A CZ    1 
ATOM   3886  N  N     . THR A 1 632 ? 93.827  110.770 138.814 1.00 77.29  ? 624 THR A N     1 
ATOM   3887  C  CA    . THR A 1 632 ? 92.838  111.241 137.858 1.00 76.25  ? 624 THR A CA    1 
ATOM   3888  C  C     . THR A 1 632 ? 93.546  111.771 136.617 1.00 78.20  ? 624 THR A C     1 
ATOM   3889  O  O     . THR A 1 632 ? 94.688  112.232 136.679 1.00 83.31  ? 624 THR A O     1 
ATOM   3890  C  CB    . THR A 1 632 ? 91.964  112.332 138.476 1.00 75.98  ? 624 THR A CB    1 
ATOM   3891  O  OG1   . THR A 1 632 ? 92.780  113.452 138.838 1.00 80.80  ? 624 THR A OG1   1 
ATOM   3892  C  CG2   . THR A 1 632 ? 91.256  111.805 139.713 1.00 71.38  ? 624 THR A CG2   1 
ATOM   3893  N  N     . PHE A 1 633 ? 92.866  111.683 135.476 1.00 73.37  ? 625 PHE A N     1 
ATOM   3894  C  CA    . PHE A 1 633 ? 93.500  112.036 134.213 1.00 74.87  ? 625 PHE A CA    1 
ATOM   3895  C  C     . PHE A 1 633 ? 93.935  113.496 134.213 1.00 81.87  ? 625 PHE A C     1 
ATOM   3896  O  O     . PHE A 1 633 ? 93.175  114.385 134.608 1.00 86.65  ? 625 PHE A O     1 
ATOM   3897  C  CB    . PHE A 1 633 ? 92.553  111.762 133.047 1.00 68.11  ? 625 PHE A CB    1 
ATOM   3898  C  CG    . PHE A 1 633 ? 93.152  112.060 131.704 1.00 66.40  ? 625 PHE A CG    1 
ATOM   3899  C  CD1   . PHE A 1 633 ? 94.267  111.371 131.263 1.00 67.83  ? 625 PHE A CD1   1 
ATOM   3900  C  CD2   . PHE A 1 633 ? 92.602  113.029 130.884 1.00 68.11  ? 625 PHE A CD2   1 
ATOM   3901  C  CE1   . PHE A 1 633 ? 94.826  111.644 130.030 1.00 67.12  ? 625 PHE A CE1   1 
ATOM   3902  C  CE2   . PHE A 1 633 ? 93.154  113.304 129.648 1.00 71.30  ? 625 PHE A CE2   1 
ATOM   3903  C  CZ    . PHE A 1 633 ? 94.268  112.612 129.222 1.00 69.76  ? 625 PHE A CZ    1 
ATOM   3904  N  N     . ARG A 1 634 ? 95.172  113.733 133.770 1.00 81.24  ? 626 ARG A N     1 
ATOM   3905  C  CA    . ARG A 1 634 ? 95.765  115.070 133.719 1.00 84.37  ? 626 ARG A CA    1 
ATOM   3906  C  C     . ARG A 1 634 ? 95.768  115.738 135.093 1.00 90.98  ? 626 ARG A C     1 
ATOM   3907  O  O     . ARG A 1 634 ? 95.555  116.945 135.216 1.00 93.36  ? 626 ARG A O     1 
ATOM   3908  C  CB    . ARG A 1 634 ? 95.056  115.953 132.691 1.00 82.91  ? 626 ARG A CB    1 
ATOM   3909  C  CG    . ARG A 1 634 ? 95.280  115.552 131.245 1.00 85.01  ? 626 ARG A CG    1 
ATOM   3910  C  CD    . ARG A 1 634 ? 94.565  116.514 130.307 1.00 85.16  ? 626 ARG A CD    1 
ATOM   3911  N  NE    . ARG A 1 634 ? 94.684  116.120 128.909 1.00 83.51  ? 626 ARG A NE    1 
ATOM   3912  C  CZ    . ARG A 1 634 ? 94.166  116.799 127.894 1.00 87.37  ? 626 ARG A CZ    1 
ATOM   3913  N  NH1   . ARG A 1 634 ? 93.486  117.918 128.087 1.00 86.56  ? 626 ARG A NH1   1 
ATOM   3914  N  NH2   . ARG A 1 634 ? 94.333  116.344 126.656 1.00 85.77  ? 626 ARG A NH2   1 
ATOM   3915  N  N     . TYR A 1 635 ? 96.012  114.945 136.138 1.00 89.24  ? 627 TYR A N     1 
ATOM   3916  C  CA    . TYR A 1 635 ? 96.066  115.505 137.485 1.00 92.45  ? 627 TYR A CA    1 
ATOM   3917  C  C     . TYR A 1 635 ? 97.318  116.349 137.688 1.00 96.15  ? 627 TYR A C     1 
ATOM   3918  O  O     . TYR A 1 635 ? 97.278  117.374 138.379 1.00 94.00  ? 627 TYR A O     1 
ATOM   3919  C  CB    . TYR A 1 635 ? 96.002  114.386 138.524 1.00 93.41  ? 627 TYR A CB    1 
ATOM   3920  C  CG    . TYR A 1 635 ? 95.982  114.873 139.955 1.00 93.06  ? 627 TYR A CG    1 
ATOM   3921  C  CD1   . TYR A 1 635 ? 94.800  115.294 140.547 1.00 93.81  ? 627 TYR A CD1   1 
ATOM   3922  C  CD2   . TYR A 1 635 ? 97.144  114.909 140.714 1.00 91.80  ? 627 TYR A CD2   1 
ATOM   3923  C  CE1   . TYR A 1 635 ? 94.774  115.741 141.853 1.00 97.72  ? 627 TYR A CE1   1 
ATOM   3924  C  CE2   . TYR A 1 635 ? 97.129  115.354 142.021 1.00 97.23  ? 627 TYR A CE2   1 
ATOM   3925  C  CZ    . TYR A 1 635 ? 95.942  115.768 142.586 1.00 102.57 ? 627 TYR A CZ    1 
ATOM   3926  O  OH    . TYR A 1 635 ? 95.919  116.212 143.888 1.00 109.15 ? 627 TYR A OH    1 
ATOM   3927  N  N     . HIS A 1 636 ? 98.439  115.934 137.102 1.00 98.11  ? 628 HIS A N     1 
ATOM   3928  C  CA    . HIS A 1 636 ? 99.712  116.603 137.324 1.00 99.24  ? 628 HIS A CA    1 
ATOM   3929  C  C     . HIS A 1 636 ? 99.970  117.758 136.366 1.00 99.36  ? 628 HIS A C     1 
ATOM   3930  O  O     . HIS A 1 636 ? 100.929 118.509 136.576 1.00 102.59 ? 628 HIS A O     1 
ATOM   3931  C  CB    . HIS A 1 636 ? 100.860 115.593 137.213 1.00 97.36  ? 628 HIS A CB    1 
ATOM   3932  C  CG    . HIS A 1 636 ? 100.731 114.427 138.144 1.00 102.51 ? 628 HIS A CG    1 
ATOM   3933  N  ND1   . HIS A 1 636 ? 101.283 114.418 139.407 1.00 106.53 ? 628 HIS A ND1   1 
ATOM   3934  C  CD2   . HIS A 1 636 ? 100.112 113.232 137.995 1.00 99.15  ? 628 HIS A CD2   1 
ATOM   3935  C  CE1   . HIS A 1 636 ? 101.010 113.268 139.996 1.00 101.76 ? 628 HIS A CE1   1 
ATOM   3936  N  NE2   . HIS A 1 636 ? 100.301 112.530 139.161 1.00 101.98 ? 628 HIS A NE2   1 
ATOM   3937  N  N     . VAL A 1 637 ? 99.151  117.927 135.329 1.00 96.51  ? 629 VAL A N     1 
ATOM   3938  C  CA    . VAL A 1 637 ? 99.420  118.944 134.319 1.00 95.80  ? 629 VAL A CA    1 
ATOM   3939  C  C     . VAL A 1 637 ? 98.250  119.911 134.199 1.00 96.91  ? 629 VAL A C     1 
ATOM   3940  O  O     . VAL A 1 637 ? 98.399  121.115 134.435 1.00 100.07 ? 629 VAL A O     1 
ATOM   3941  C  CB    . VAL A 1 637 ? 99.729  118.301 132.954 1.00 100.19 ? 629 VAL A CB    1 
ATOM   3942  C  CG1   . VAL A 1 637 ? 100.078 119.373 131.933 1.00 101.27 ? 629 VAL A CG1   1 
ATOM   3943  C  CG2   . VAL A 1 637 ? 100.856 117.287 133.081 1.00 101.66 ? 629 VAL A CG2   1 
ATOM   3944  N  N     . TRP A 1 638 ? 97.078  119.393 133.828 1.00 95.20  ? 630 TRP A N     1 
ATOM   3945  C  CA    . TRP A 1 638 ? 95.920  120.230 133.495 1.00 97.75  ? 630 TRP A CA    1 
ATOM   3946  C  C     . TRP A 1 638 ? 94.670  119.582 134.088 1.00 93.31  ? 630 TRP A C     1 
ATOM   3947  O  O     . TRP A 1 638 ? 94.003  118.779 133.431 1.00 95.27  ? 630 TRP A O     1 
ATOM   3948  C  CB    . TRP A 1 638 ? 95.811  120.402 131.983 1.00 95.97  ? 630 TRP A CB    1 
ATOM   3949  C  CG    . TRP A 1 638 ? 94.748  121.351 131.537 1.00 93.46  ? 630 TRP A CG    1 
ATOM   3950  C  CD1   . TRP A 1 638 ? 93.451  121.050 131.248 1.00 91.92  ? 630 TRP A CD1   1 
ATOM   3951  C  CD2   . TRP A 1 638 ? 94.895  122.757 131.310 1.00 94.24  ? 630 TRP A CD2   1 
ATOM   3952  N  NE1   . TRP A 1 638 ? 92.777  122.183 130.863 1.00 94.16  ? 630 TRP A NE1   1 
ATOM   3953  C  CE2   . TRP A 1 638 ? 93.641  123.245 130.893 1.00 95.31  ? 630 TRP A CE2   1 
ATOM   3954  C  CE3   . TRP A 1 638 ? 95.963  123.652 131.424 1.00 93.52  ? 630 TRP A CE3   1 
ATOM   3955  C  CZ2   . TRP A 1 638 ? 93.427  124.587 130.589 1.00 94.65  ? 630 TRP A CZ2   1 
ATOM   3956  C  CZ3   . TRP A 1 638 ? 95.748  124.983 131.121 1.00 92.60  ? 630 TRP A CZ3   1 
ATOM   3957  C  CH2   . TRP A 1 638 ? 94.490  125.438 130.709 1.00 94.31  ? 630 TRP A CH2   1 
ATOM   3958  N  N     . THR A 1 639 ? 94.346  119.946 135.330 1.00 87.93  ? 631 THR A N     1 
ATOM   3959  C  CA    . THR A 1 639 ? 93.181  119.382 135.999 1.00 83.73  ? 631 THR A CA    1 
ATOM   3960  C  C     . THR A 1 639 ? 91.867  119.971 135.506 1.00 82.70  ? 631 THR A C     1 
ATOM   3961  O  O     . THR A 1 639 ? 90.809  119.406 135.801 1.00 80.52  ? 631 THR A O     1 
ATOM   3962  C  CB    . THR A 1 639 ? 93.280  119.586 137.512 1.00 85.11  ? 631 THR A CB    1 
ATOM   3963  O  OG1   . THR A 1 639 ? 93.435  120.981 137.801 1.00 90.69  ? 631 THR A OG1   1 
ATOM   3964  C  CG2   . THR A 1 639 ? 94.461  118.822 138.077 1.00 87.54  ? 631 THR A CG2   1 
ATOM   3965  N  N     . LYS A 1 640 ? 91.907  121.083 134.768 1.00 81.89  ? 632 LYS A N     1 
ATOM   3966  C  CA    . LYS A 1 640 ? 90.678  121.702 134.284 1.00 79.76  ? 632 LYS A CA    1 
ATOM   3967  C  C     . LYS A 1 640 ? 89.911  120.799 133.329 1.00 75.77  ? 632 LYS A C     1 
ATOM   3968  O  O     . LYS A 1 640 ? 88.693  120.954 133.195 1.00 75.74  ? 632 LYS A O     1 
ATOM   3969  C  CB    . LYS A 1 640 ? 90.990  123.029 133.593 1.00 84.26  ? 632 LYS A CB    1 
ATOM   3970  C  CG    . LYS A 1 640 ? 91.651  124.061 134.487 1.00 91.88  ? 632 LYS A CG    1 
ATOM   3971  C  CD    . LYS A 1 640 ? 91.907  125.355 133.731 1.00 98.35  ? 632 LYS A CD    1 
ATOM   3972  C  CE    . LYS A 1 640 ? 92.568  126.395 134.621 1.00 103.68 ? 632 LYS A CE    1 
ATOM   3973  N  NZ    . LYS A 1 640 ? 92.836  127.662 133.886 1.00 103.63 ? 632 LYS A NZ    1 
ATOM   3974  N  N     . GLY A 1 641 ? 90.594  119.864 132.665 1.00 71.04  ? 633 GLY A N     1 
ATOM   3975  C  CA    . GLY A 1 641 ? 89.918  119.018 131.696 1.00 70.29  ? 633 GLY A CA    1 
ATOM   3976  C  C     . GLY A 1 641 ? 88.846  118.145 132.319 1.00 65.42  ? 633 GLY A C     1 
ATOM   3977  O  O     . GLY A 1 641 ? 87.747  118.012 131.776 1.00 65.52  ? 633 GLY A O     1 
ATOM   3978  N  N     . HIS A 1 642 ? 89.146  117.542 133.469 1.00 62.22  ? 634 HIS A N     1 
ATOM   3979  C  CA    . HIS A 1 642 ? 88.207  116.659 134.150 1.00 61.55  ? 634 HIS A CA    1 
ATOM   3980  C  C     . HIS A 1 642 ? 87.836  117.171 135.536 1.00 65.48  ? 634 HIS A C     1 
ATOM   3981  O  O     . HIS A 1 642 ? 87.363  116.395 136.371 1.00 65.48  ? 634 HIS A O     1 
ATOM   3982  C  CB    . HIS A 1 642 ? 88.774  115.242 134.239 1.00 60.43  ? 634 HIS A CB    1 
ATOM   3983  C  CG    . HIS A 1 642 ? 88.873  114.551 132.916 1.00 56.98  ? 634 HIS A CG    1 
ATOM   3984  N  ND1   . HIS A 1 642 ? 87.968  113.596 132.506 1.00 57.43  ? 634 HIS A ND1   1 
ATOM   3985  C  CD2   . HIS A 1 642 ? 89.764  114.683 131.905 1.00 58.01  ? 634 HIS A CD2   1 
ATOM   3986  C  CE1   . HIS A 1 642 ? 88.300  113.166 131.302 1.00 55.76  ? 634 HIS A CE1   1 
ATOM   3987  N  NE2   . HIS A 1 642 ? 89.387  113.809 130.915 1.00 56.16  ? 634 HIS A NE2   1 
ATOM   3988  N  N     . ALA A 1 643 ? 88.052  118.458 135.802 1.00 64.40  ? 635 ALA A N     1 
ATOM   3989  C  CA    . ALA A 1 643 ? 87.634  119.026 137.082 1.00 60.89  ? 635 ALA A CA    1 
ATOM   3990  C  C     . ALA A 1 643 ? 86.130  118.924 137.308 1.00 60.89  ? 635 ALA A C     1 
ATOM   3991  O  O     . ALA A 1 643 ? 85.725  118.510 138.408 1.00 62.03  ? 635 ALA A O     1 
ATOM   3992  C  CB    . ALA A 1 643 ? 88.125  120.474 137.192 1.00 63.38  ? 635 ALA A CB    1 
ATOM   3993  N  N     . PRO A 1 644 ? 85.256  119.265 136.351 1.00 59.90  ? 636 PRO A N     1 
ATOM   3994  C  CA    . PRO A 1 644 ? 83.811  119.136 136.606 1.00 60.01  ? 636 PRO A CA    1 
ATOM   3995  C  C     . PRO A 1 644 ? 83.335  117.706 136.789 1.00 58.33  ? 636 PRO A C     1 
ATOM   3996  O  O     . PRO A 1 644 ? 82.151  117.508 137.088 1.00 55.37  ? 636 PRO A O     1 
ATOM   3997  C  CB    . PRO A 1 644 ? 83.175  119.767 135.360 1.00 54.02  ? 636 PRO A CB    1 
ATOM   3998  C  CG    . PRO A 1 644 ? 84.226  120.647 134.803 1.00 56.70  ? 636 PRO A CG    1 
ATOM   3999  C  CD    . PRO A 1 644 ? 85.508  119.937 135.063 1.00 58.30  ? 636 PRO A CD    1 
ATOM   4000  N  N     . THR A 1 645 ? 84.203  116.707 136.611 1.00 58.63  ? 637 THR A N     1 
ATOM   4001  C  CA    . THR A 1 645 ? 83.782  115.325 136.812 1.00 60.77  ? 637 THR A CA    1 
ATOM   4002  C  C     . THR A 1 645 ? 83.382  115.069 138.259 1.00 63.37  ? 637 THR A C     1 
ATOM   4003  O  O     . THR A 1 645 ? 82.553  114.191 138.526 1.00 65.21  ? 637 THR A O     1 
ATOM   4004  C  CB    . THR A 1 645 ? 84.899  114.368 136.393 1.00 60.18  ? 637 THR A CB    1 
ATOM   4005  O  OG1   . THR A 1 645 ? 85.462  114.804 135.150 1.00 56.00  ? 637 THR A OG1   1 
ATOM   4006  C  CG2   . THR A 1 645 ? 84.357  112.959 136.221 1.00 61.57  ? 637 THR A CG2   1 
ATOM   4007  N  N     . ASN A 1 646 ? 83.950  115.829 139.198 1.00 60.41  ? 638 ASN A N     1 
ATOM   4008  C  CA    . ASN A 1 646 ? 83.655  115.697 140.624 1.00 60.06  ? 638 ASN A CA    1 
ATOM   4009  C  C     . ASN A 1 646 ? 83.963  114.279 141.111 1.00 63.48  ? 638 ASN A C     1 
ATOM   4010  O  O     . ASN A 1 646 ? 83.079  113.521 141.516 1.00 64.03  ? 638 ASN A O     1 
ATOM   4011  C  CB    . ASN A 1 646 ? 82.203  116.089 140.922 1.00 60.32  ? 638 ASN A CB    1 
ATOM   4012  C  CG    . ASN A 1 646 ? 81.972  116.411 142.386 1.00 63.23  ? 638 ASN A CG    1 
ATOM   4013  O  OD1   . ASN A 1 646 ? 82.703  115.947 143.260 1.00 65.24  ? 638 ASN A OD1   1 
ATOM   4014  N  ND2   . ASN A 1 646 ? 80.948  117.210 142.659 1.00 60.51  ? 638 ASN A ND2   1 
ATOM   4015  N  N     . PHE A 1 647 ? 85.251  113.929 141.050 1.00 63.43  ? 639 PHE A N     1 
ATOM   4016  C  CA    . PHE A 1 647 ? 85.683  112.607 141.489 1.00 64.48  ? 639 PHE A CA    1 
ATOM   4017  C  C     . PHE A 1 647 ? 85.394  112.380 142.966 1.00 68.97  ? 639 PHE A C     1 
ATOM   4018  O  O     . PHE A 1 647 ? 85.150  111.241 143.382 1.00 67.48  ? 639 PHE A O     1 
ATOM   4019  C  CB    . PHE A 1 647 ? 87.174  112.421 141.211 1.00 64.60  ? 639 PHE A CB    1 
ATOM   4020  C  CG    . PHE A 1 647 ? 87.531  112.473 139.754 1.00 68.39  ? 639 PHE A CG    1 
ATOM   4021  C  CD1   . PHE A 1 647 ? 87.446  111.337 138.967 1.00 68.13  ? 639 PHE A CD1   1 
ATOM   4022  C  CD2   . PHE A 1 647 ? 87.958  113.654 139.173 1.00 67.79  ? 639 PHE A CD2   1 
ATOM   4023  C  CE1   . PHE A 1 647 ? 87.777  111.380 137.628 1.00 66.68  ? 639 PHE A CE1   1 
ATOM   4024  C  CE2   . PHE A 1 647 ? 88.290  113.702 137.834 1.00 68.21  ? 639 PHE A CE2   1 
ATOM   4025  C  CZ    . PHE A 1 647 ? 88.199  112.564 137.061 1.00 67.83  ? 639 PHE A CZ    1 
ATOM   4026  N  N     . ALA A 1 648 ? 85.423  113.444 143.773 1.00 68.38  ? 640 ALA A N     1 
ATOM   4027  C  CA    . ALA A 1 648 ? 85.140  113.300 145.197 1.00 66.89  ? 640 ALA A CA    1 
ATOM   4028  C  C     . ALA A 1 648 ? 83.730  112.775 145.427 1.00 66.85  ? 640 ALA A C     1 
ATOM   4029  O  O     . ALA A 1 648 ? 83.516  111.890 146.263 1.00 70.52  ? 640 ALA A O     1 
ATOM   4030  C  CB    . ALA A 1 648 ? 85.341  114.636 145.910 1.00 70.01  ? 640 ALA A CB    1 
ATOM   4031  N  N     . LYS A 1 649 ? 82.753  113.308 144.691 1.00 63.00  ? 641 LYS A N     1 
ATOM   4032  C  CA    . LYS A 1 649 ? 81.401  112.769 144.768 1.00 64.13  ? 641 LYS A CA    1 
ATOM   4033  C  C     . LYS A 1 649 ? 81.314  111.395 144.118 1.00 65.34  ? 641 LYS A C     1 
ATOM   4034  O  O     . LYS A 1 649 ? 80.521  110.553 144.553 1.00 67.95  ? 641 LYS A O     1 
ATOM   4035  C  CB    . LYS A 1 649 ? 80.414  113.735 144.114 1.00 60.25  ? 641 LYS A CB    1 
ATOM   4036  C  CG    . LYS A 1 649 ? 78.964  113.296 144.199 1.00 59.75  ? 641 LYS A CG    1 
ATOM   4037  C  CD    . LYS A 1 649 ? 78.034  114.337 143.603 1.00 59.00  ? 641 LYS A CD    1 
ATOM   4038  C  CE    . LYS A 1 649 ? 76.584  113.893 143.697 1.00 58.38  ? 641 LYS A CE    1 
ATOM   4039  N  NZ    . LYS A 1 649 ? 75.651  114.925 143.169 1.00 67.34  ? 641 LYS A NZ    1 
ATOM   4040  N  N     . TRP A 1 650 ? 82.125  111.149 143.087 1.00 64.47  ? 642 TRP A N     1 
ATOM   4041  C  CA    . TRP A 1 650 ? 82.088  109.871 142.387 1.00 64.45  ? 642 TRP A CA    1 
ATOM   4042  C  C     . TRP A 1 650 ? 82.609  108.727 143.247 1.00 65.92  ? 642 TRP A C     1 
ATOM   4043  O  O     . TRP A 1 650 ? 82.232  107.572 143.022 1.00 67.33  ? 642 TRP A O     1 
ATOM   4044  C  CB    . TRP A 1 650 ? 82.895  109.967 141.089 1.00 63.95  ? 642 TRP A CB    1 
ATOM   4045  C  CG    . TRP A 1 650 ? 82.986  108.678 140.335 1.00 60.48  ? 642 TRP A CG    1 
ATOM   4046  C  CD1   . TRP A 1 650 ? 82.051  108.151 139.494 1.00 61.85  ? 642 TRP A CD1   1 
ATOM   4047  C  CD2   . TRP A 1 650 ? 84.077  107.752 140.352 1.00 56.30  ? 642 TRP A CD2   1 
ATOM   4048  N  NE1   . TRP A 1 650 ? 82.490  106.953 138.989 1.00 59.05  ? 642 TRP A NE1   1 
ATOM   4049  C  CE2   . TRP A 1 650 ? 83.733  106.686 139.500 1.00 57.43  ? 642 TRP A CE2   1 
ATOM   4050  C  CE3   . TRP A 1 650 ? 85.311  107.721 141.007 1.00 56.80  ? 642 TRP A CE3   1 
ATOM   4051  C  CZ2   . TRP A 1 650 ? 84.577  105.601 139.286 1.00 59.24  ? 642 TRP A CZ2   1 
ATOM   4052  C  CZ3   . TRP A 1 650 ? 86.145  106.643 140.794 1.00 57.63  ? 642 TRP A CZ3   1 
ATOM   4053  C  CH2   . TRP A 1 650 ? 85.776  105.599 139.940 1.00 58.47  ? 642 TRP A CH2   1 
ATOM   4054  N  N     . ARG A 1 651 ? 83.467  109.024 144.227 1.00 67.83  ? 643 ARG A N     1 
ATOM   4055  C  CA    . ARG A 1 651 ? 84.044  107.965 145.052 1.00 70.85  ? 643 ARG A CA    1 
ATOM   4056  C  C     . ARG A 1 651 ? 82.970  107.207 145.824 1.00 71.25  ? 643 ARG A C     1 
ATOM   4057  O  O     . ARG A 1 651 ? 83.012  105.974 145.910 1.00 73.48  ? 643 ARG A O     1 
ATOM   4058  C  CB    . ARG A 1 651 ? 85.078  108.552 146.013 1.00 73.30  ? 643 ARG A CB    1 
ATOM   4059  C  CG    . ARG A 1 651 ? 86.344  109.056 145.341 1.00 72.52  ? 643 ARG A CG    1 
ATOM   4060  C  CD    . ARG A 1 651 ? 87.270  109.727 146.342 1.00 75.31  ? 643 ARG A CD    1 
ATOM   4061  N  NE    . ARG A 1 651 ? 87.714  108.805 147.380 1.00 75.58  ? 643 ARG A NE    1 
ATOM   4062  C  CZ    . ARG A 1 651 ? 88.869  108.155 147.360 1.00 77.20  ? 643 ARG A CZ    1 
ATOM   4063  N  NH1   . ARG A 1 651 ? 89.733  108.310 146.370 1.00 78.96  ? 643 ARG A NH1   1 
ATOM   4064  N  NH2   . ARG A 1 651 ? 89.166  107.329 148.359 1.00 76.68  ? 643 ARG A NH2   1 
ATOM   4065  N  N     . THR A 1 652 ? 82.004  107.922 146.394 1.00 69.54  ? 644 THR A N     1 
ATOM   4066  C  CA    . THR A 1 652 ? 80.955  107.310 147.197 1.00 71.97  ? 644 THR A CA    1 
ATOM   4067  C  C     . THR A 1 652 ? 79.619  107.214 146.473 1.00 75.17  ? 644 THR A C     1 
ATOM   4068  O  O     . THR A 1 652 ? 78.648  106.725 147.058 1.00 78.15  ? 644 THR A O     1 
ATOM   4069  C  CB    . THR A 1 652 ? 80.771  108.090 148.503 1.00 77.56  ? 644 THR A CB    1 
ATOM   4070  O  OG1   . THR A 1 652 ? 80.463  109.457 148.205 1.00 72.49  ? 644 THR A OG1   1 
ATOM   4071  C  CG2   . THR A 1 652 ? 82.040  108.033 149.338 1.00 80.71  ? 644 THR A CG2   1 
ATOM   4072  N  N     . ALA A 1 653 ? 79.542  107.663 145.223 1.00 75.25  ? 645 ALA A N     1 
ATOM   4073  C  CA    . ALA A 1 653 ? 78.276  107.667 144.505 1.00 73.88  ? 645 ALA A CA    1 
ATOM   4074  C  C     . ALA A 1 653 ? 77.849  106.252 144.138 1.00 79.17  ? 645 ALA A C     1 
ATOM   4075  O  O     . ALA A 1 653 ? 78.675  105.408 143.778 1.00 77.56  ? 645 ALA A O     1 
ATOM   4076  C  CB    . ALA A 1 653 ? 78.382  108.523 143.245 1.00 67.88  ? 645 ALA A CB    1 
ATOM   4077  N  N     . THR A 1 654 ? 76.544  105.996 144.234 1.00 82.42  ? 646 THR A N     1 
ATOM   4078  C  CA    . THR A 1 654 ? 75.968  104.719 143.841 1.00 80.36  ? 646 THR A CA    1 
ATOM   4079  C  C     . THR A 1 654 ? 74.979  104.828 142.691 1.00 72.31  ? 646 THR A C     1 
ATOM   4080  O  O     . THR A 1 654 ? 74.575  103.794 142.149 1.00 69.96  ? 646 THR A O     1 
ATOM   4081  C  CB    . THR A 1 654 ? 75.266  104.053 145.035 1.00 87.06  ? 646 THR A CB    1 
ATOM   4082  O  OG1   . THR A 1 654 ? 74.208  104.899 145.503 1.00 86.14  ? 646 THR A OG1   1 
ATOM   4083  C  CG2   . THR A 1 654 ? 76.253  103.814 146.166 1.00 83.92  ? 646 THR A CG2   1 
ATOM   4084  N  N     . THR A 1 655 ? 74.575  106.036 142.309 1.00 72.79  ? 647 THR A N     1 
ATOM   4085  C  CA    . THR A 1 655 ? 73.669  106.276 141.199 1.00 74.70  ? 647 THR A CA    1 
ATOM   4086  C  C     . THR A 1 655 ? 74.251  107.347 140.290 1.00 73.35  ? 647 THR A C     1 
ATOM   4087  O  O     . THR A 1 655 ? 74.999  108.215 140.750 1.00 74.58  ? 647 THR A O     1 
ATOM   4088  C  CB    . THR A 1 655 ? 72.284  106.722 141.693 1.00 73.76  ? 647 THR A CB    1 
ATOM   4089  O  OG1   . THR A 1 655 ? 72.416  107.914 142.478 1.00 75.81  ? 647 THR A OG1   1 
ATOM   4090  C  CG2   . THR A 1 655 ? 71.638  105.633 142.535 1.00 74.49  ? 647 THR A CG2   1 
ATOM   4091  N  N     . PRO A 1 656 ? 73.934  107.307 138.995 1.00 68.05  ? 648 PRO A N     1 
ATOM   4092  C  CA    . PRO A 1 656 ? 74.453  108.332 138.081 1.00 67.14  ? 648 PRO A CA    1 
ATOM   4093  C  C     . PRO A 1 656 ? 73.978  109.718 138.486 1.00 62.04  ? 648 PRO A C     1 
ATOM   4094  O  O     . PRO A 1 656 ? 72.844  109.898 138.933 1.00 62.06  ? 648 PRO A O     1 
ATOM   4095  C  CB    . PRO A 1 656 ? 73.883  107.916 136.720 1.00 71.80  ? 648 PRO A CB    1 
ATOM   4096  C  CG    . PRO A 1 656 ? 73.567  106.464 136.864 1.00 71.61  ? 648 PRO A CG    1 
ATOM   4097  C  CD    . PRO A 1 656 ? 73.147  106.283 138.288 1.00 68.56  ? 648 PRO A CD    1 
ATOM   4098  N  N     . TYR A 1 657 ? 74.855  110.706 138.325 1.00 60.44  ? 649 TYR A N     1 
ATOM   4099  C  CA    . TYR A 1 657 ? 74.540  112.066 138.737 1.00 60.70  ? 649 TYR A CA    1 
ATOM   4100  C  C     . TYR A 1 657 ? 74.907  113.053 137.640 1.00 61.45  ? 649 TYR A C     1 
ATOM   4101  O  O     . TYR A 1 657 ? 75.886  112.868 136.915 1.00 64.51  ? 649 TYR A O     1 
ATOM   4102  C  CB    . TYR A 1 657 ? 75.257  112.437 140.042 1.00 60.68  ? 649 TYR A CB    1 
ATOM   4103  C  CG    . TYR A 1 657 ? 76.765  112.367 139.978 1.00 60.13  ? 649 TYR A CG    1 
ATOM   4104  C  CD1   . TYR A 1 657 ? 77.435  111.175 140.216 1.00 60.93  ? 649 TYR A CD1   1 
ATOM   4105  C  CD2   . TYR A 1 657 ? 77.519  113.497 139.697 1.00 59.90  ? 649 TYR A CD2   1 
ATOM   4106  C  CE1   . TYR A 1 657 ? 78.812  111.109 140.165 1.00 61.19  ? 649 TYR A CE1   1 
ATOM   4107  C  CE2   . TYR A 1 657 ? 78.895  113.441 139.643 1.00 60.92  ? 649 TYR A CE2   1 
ATOM   4108  C  CZ    . TYR A 1 657 ? 79.536  112.246 139.879 1.00 59.90  ? 649 TYR A CZ    1 
ATOM   4109  O  OH    . TYR A 1 657 ? 80.908  112.192 139.825 1.00 61.07  ? 649 TYR A OH    1 
ATOM   4110  N  N     . ARG A 1 658 ? 74.111  114.112 137.529 1.00 61.18  ? 650 ARG A N     1 
ATOM   4111  C  CA    . ARG A 1 658 ? 74.324  115.115 136.497 1.00 55.78  ? 650 ARG A CA    1 
ATOM   4112  C  C     . ARG A 1 658 ? 75.349  116.148 136.945 1.00 57.62  ? 650 ARG A C     1 
ATOM   4113  O  O     . ARG A 1 658 ? 75.388  116.542 138.114 1.00 64.09  ? 650 ARG A O     1 
ATOM   4114  C  CB    . ARG A 1 658 ? 73.006  115.808 136.147 1.00 56.37  ? 650 ARG A CB    1 
ATOM   4115  C  CG    . ARG A 1 658 ? 73.137  116.889 135.086 1.00 61.27  ? 650 ARG A CG    1 
ATOM   4116  C  CD    . ARG A 1 658 ? 71.805  117.555 134.794 1.00 69.17  ? 650 ARG A CD    1 
ATOM   4117  N  NE    . ARG A 1 658 ? 71.945  118.639 133.829 1.00 75.61  ? 650 ARG A NE    1 
ATOM   4118  C  CZ    . ARG A 1 658 ? 70.936  119.361 133.361 1.00 81.89  ? 650 ARG A CZ    1 
ATOM   4119  N  NH1   . ARG A 1 658 ? 69.690  119.139 133.746 1.00 82.67  ? 650 ARG A NH1   1 
ATOM   4120  N  NH2   . ARG A 1 658 ? 71.184  120.330 132.485 1.00 84.31  ? 650 ARG A NH2   1 
ATOM   4121  N  N     . VAL A 1 659 ? 76.183  116.585 136.004 1.00 54.24  ? 651 VAL A N     1 
ATOM   4122  C  CA    . VAL A 1 659 ? 77.135  117.662 136.229 1.00 52.99  ? 651 VAL A CA    1 
ATOM   4123  C  C     . VAL A 1 659 ? 76.862  118.764 135.211 1.00 53.51  ? 651 VAL A C     1 
ATOM   4124  O  O     . VAL A 1 659 ? 76.066  118.606 134.286 1.00 50.73  ? 651 VAL A O     1 
ATOM   4125  C  CB    . VAL A 1 659 ? 78.597  117.184 136.145 1.00 53.57  ? 651 VAL A CB    1 
ATOM   4126  C  CG1   . VAL A 1 659 ? 78.863  116.109 137.184 1.00 54.04  ? 651 VAL A CG1   1 
ATOM   4127  C  CG2   . VAL A 1 659 ? 78.909  116.676 134.751 1.00 57.18  ? 651 VAL A CG2   1 
ATOM   4128  N  N     . GLU A 1 660 ? 77.537  119.893 135.397 1.00 57.54  ? 652 GLU A N     1 
ATOM   4129  C  CA    . GLU A 1 660 ? 77.341  121.065 134.560 1.00 57.37  ? 652 GLU A CA    1 
ATOM   4130  C  C     . GLU A 1 660 ? 78.616  121.378 133.791 1.00 56.30  ? 652 GLU A C     1 
ATOM   4131  O  O     . GLU A 1 660 ? 79.726  121.098 134.253 1.00 55.64  ? 652 GLU A O     1 
ATOM   4132  C  CB    . GLU A 1 660 ? 76.925  122.282 135.395 1.00 60.53  ? 652 GLU A CB    1 
ATOM   4133  C  CG    . GLU A 1 660 ? 75.660  122.069 136.212 1.00 62.84  ? 652 GLU A CG    1 
ATOM   4134  C  CD    . GLU A 1 660 ? 74.431  121.862 135.349 1.00 70.57  ? 652 GLU A CD    1 
ATOM   4135  O  OE1   . GLU A 1 660 ? 74.392  122.404 134.225 1.00 72.60  ? 652 GLU A OE1   1 
ATOM   4136  O  OE2   . GLU A 1 660 ? 73.504  121.153 135.793 1.00 72.24  ? 652 GLU A OE2   1 
ATOM   4137  N  N     . TRP A 1 661 ? 78.444  121.962 132.609 1.00 55.92  ? 653 TRP A N     1 
ATOM   4138  C  CA    . TRP A 1 661 ? 79.580  122.294 131.763 1.00 59.78  ? 653 TRP A CA    1 
ATOM   4139  C  C     . TRP A 1 661 ? 80.412  123.407 132.386 1.00 58.97  ? 653 TRP A C     1 
ATOM   4140  O  O     . TRP A 1 661 ? 79.880  124.337 132.998 1.00 61.91  ? 653 TRP A O     1 
ATOM   4141  C  CB    . TRP A 1 661 ? 79.098  122.715 130.375 1.00 60.55  ? 653 TRP A CB    1 
ATOM   4142  C  CG    . TRP A 1 661 ? 80.209  123.055 129.432 1.00 66.31  ? 653 TRP A CG    1 
ATOM   4143  C  CD1   . TRP A 1 661 ? 80.823  122.214 128.553 1.00 66.88  ? 653 TRP A CD1   1 
ATOM   4144  C  CD2   . TRP A 1 661 ? 80.841  124.331 129.275 1.00 70.63  ? 653 TRP A CD2   1 
ATOM   4145  N  NE1   . TRP A 1 661 ? 81.797  122.886 127.857 1.00 69.57  ? 653 TRP A NE1   1 
ATOM   4146  C  CE2   . TRP A 1 661 ? 81.828  124.188 128.282 1.00 74.35  ? 653 TRP A CE2   1 
ATOM   4147  C  CE3   . TRP A 1 661 ? 80.668  125.581 129.877 1.00 70.24  ? 653 TRP A CE3   1 
ATOM   4148  C  CZ2   . TRP A 1 661 ? 82.639  125.245 127.879 1.00 79.56  ? 653 TRP A CZ2   1 
ATOM   4149  C  CZ3   . TRP A 1 661 ? 81.474  126.628 129.476 1.00 74.28  ? 653 TRP A CZ3   1 
ATOM   4150  C  CH2   . TRP A 1 661 ? 82.447  126.454 128.487 1.00 78.03  ? 653 TRP A CH2   1 
ATOM   4151  N  N     . GLU A 1 662 ? 81.730  123.305 132.229 1.00 57.32  ? 654 GLU A N     1 
ATOM   4152  C  CA    . GLU A 1 662 ? 82.654  124.338 132.669 1.00 62.09  ? 654 GLU A CA    1 
ATOM   4153  C  C     . GLU A 1 662 ? 83.702  124.549 131.587 1.00 66.46  ? 654 GLU A C     1 
ATOM   4154  O  O     . GLU A 1 662 ? 83.754  123.821 130.593 1.00 68.57  ? 654 GLU A O     1 
ATOM   4155  C  CB    . GLU A 1 662 ? 83.314  123.979 134.005 1.00 63.86  ? 654 GLU A CB    1 
ATOM   4156  C  CG    . GLU A 1 662 ? 82.339  123.849 135.166 1.00 72.68  ? 654 GLU A CG    1 
ATOM   4157  C  CD    . GLU A 1 662 ? 83.028  123.535 136.479 1.00 75.88  ? 654 GLU A CD    1 
ATOM   4158  O  OE1   . GLU A 1 662 ? 84.265  123.690 136.556 1.00 79.72  ? 654 GLU A OE1   1 
ATOM   4159  O  OE2   . GLU A 1 662 ? 82.333  123.130 137.434 1.00 74.40  ? 654 GLU A OE2   1 
ATOM   4160  N  N     . ALA A 1 663 ? 84.541  125.563 131.786 1.00 68.73  ? 655 ALA A N     1 
ATOM   4161  C  CA    . ALA A 1 663 ? 85.544  125.909 130.788 1.00 69.88  ? 655 ALA A CA    1 
ATOM   4162  C  C     . ALA A 1 663 ? 86.530  124.765 130.585 1.00 70.71  ? 655 ALA A C     1 
ATOM   4163  O  O     . ALA A 1 663 ? 87.004  124.152 131.546 1.00 67.72  ? 655 ALA A O     1 
ATOM   4164  C  CB    . ALA A 1 663 ? 86.289  127.178 131.204 1.00 73.51  ? 655 ALA A CB    1 
ATOM   4165  N  N     . ASP A 1 664 ? 86.827  124.478 129.317 1.00 74.10  ? 656 ASP A N     1 
ATOM   4166  C  CA    . ASP A 1 664 ? 87.773  123.442 128.905 1.00 67.05  ? 656 ASP A CA    1 
ATOM   4167  C  C     . ASP A 1 664 ? 87.365  122.051 129.378 1.00 59.99  ? 656 ASP A C     1 
ATOM   4168  O  O     . ASP A 1 664 ? 88.214  121.164 129.506 1.00 59.56  ? 656 ASP A O     1 
ATOM   4169  C  CB    . ASP A 1 664 ? 89.196  123.763 129.378 1.00 75.07  ? 656 ASP A CB    1 
ATOM   4170  C  CG    . ASP A 1 664 ? 89.733  125.045 128.775 1.00 82.20  ? 656 ASP A CG    1 
ATOM   4171  O  OD1   . ASP A 1 664 ? 89.312  125.400 127.655 1.00 80.29  ? 656 ASP A OD1   1 
ATOM   4172  O  OD2   . ASP A 1 664 ? 90.577  125.700 129.422 1.00 91.26  ? 656 ASP A OD2   1 
ATOM   4173  N  N     . PHE A 1 665 ? 86.079  121.840 129.644 1.00 55.91  ? 657 PHE A N     1 
ATOM   4174  C  CA    . PHE A 1 665 ? 85.594  120.512 129.991 1.00 53.46  ? 657 PHE A CA    1 
ATOM   4175  C  C     . PHE A 1 665 ? 85.698  119.588 128.783 1.00 59.79  ? 657 PHE A C     1 
ATOM   4176  O  O     . PHE A 1 665 ? 85.338  119.962 127.664 1.00 61.01  ? 657 PHE A O     1 
ATOM   4177  C  CB    . PHE A 1 665 ? 84.147  120.589 130.474 1.00 49.99  ? 657 PHE A CB    1 
ATOM   4178  C  CG    . PHE A 1 665 ? 83.671  119.350 131.177 1.00 46.47  ? 657 PHE A CG    1 
ATOM   4179  C  CD1   . PHE A 1 665 ? 84.569  118.492 131.785 1.00 47.61  ? 657 PHE A CD1   1 
ATOM   4180  C  CD2   . PHE A 1 665 ? 82.324  119.042 131.223 1.00 47.39  ? 657 PHE A CD2   1 
ATOM   4181  C  CE1   . PHE A 1 665 ? 84.131  117.353 132.430 1.00 50.51  ? 657 PHE A CE1   1 
ATOM   4182  C  CE2   . PHE A 1 665 ? 81.881  117.905 131.866 1.00 46.70  ? 657 PHE A CE2   1 
ATOM   4183  C  CZ    . PHE A 1 665 ? 82.785  117.059 132.471 1.00 49.63  ? 657 PHE A CZ    1 
ATOM   4184  N  N     . GLU A 1 666 ? 86.193  118.374 129.011 1.00 54.98  ? 658 GLU A N     1 
ATOM   4185  C  CA    . GLU A 1 666 ? 86.371  117.394 127.940 1.00 47.42  ? 658 GLU A CA    1 
ATOM   4186  C  C     . GLU A 1 666 ? 86.344  115.988 128.517 1.00 45.94  ? 658 GLU A C     1 
ATOM   4187  O  O     . GLU A 1 666 ? 87.384  115.339 128.679 1.00 48.49  ? 658 GLU A O     1 
ATOM   4188  C  CB    . GLU A 1 666 ? 87.673  117.646 127.177 1.00 54.19  ? 658 GLU A CB    1 
ATOM   4189  C  CG    . GLU A 1 666 ? 88.841  118.055 128.057 1.00 54.85  ? 658 GLU A CG    1 
ATOM   4190  C  CD    . GLU A 1 666 ? 90.113  118.275 127.266 1.00 65.60  ? 658 GLU A CD    1 
ATOM   4191  O  OE1   . GLU A 1 666 ? 90.140  117.913 126.072 1.00 69.67  ? 658 GLU A OE1   1 
ATOM   4192  O  OE2   . GLU A 1 666 ? 91.086  118.810 127.837 1.00 74.69  ? 658 GLU A OE2   1 
ATOM   4193  N  N     . PRO A 1 667 ? 85.163  115.477 128.835 1.00 44.70  ? 659 PRO A N     1 
ATOM   4194  C  CA    . PRO A 1 667 ? 85.041  114.100 129.318 1.00 45.21  ? 659 PRO A CA    1 
ATOM   4195  C  C     . PRO A 1 667 ? 84.994  113.116 128.152 1.00 48.04  ? 659 PRO A C     1 
ATOM   4196  O  O     . PRO A 1 667 ? 85.138  113.479 126.987 1.00 45.78  ? 659 PRO A O     1 
ATOM   4197  C  CB    . PRO A 1 667 ? 83.721  114.126 130.086 1.00 40.66  ? 659 PRO A CB    1 
ATOM   4198  C  CG    . PRO A 1 667 ? 82.911  115.134 129.360 1.00 43.47  ? 659 PRO A CG    1 
ATOM   4199  C  CD    . PRO A 1 667 ? 83.873  116.187 128.875 1.00 46.50  ? 659 PRO A CD    1 
ATOM   4200  N  N     . TYR A 1 668 ? 84.794  111.845 128.492 1.00 49.19  ? 660 TYR A N     1 
ATOM   4201  C  CA    . TYR A 1 668 ? 84.632  110.774 127.517 1.00 45.03  ? 660 TYR A CA    1 
ATOM   4202  C  C     . TYR A 1 668 ? 83.217  110.230 127.640 1.00 46.94  ? 660 TYR A C     1 
ATOM   4203  O  O     . TYR A 1 668 ? 82.860  109.637 128.664 1.00 51.85  ? 660 TYR A O     1 
ATOM   4204  C  CB    . TYR A 1 668 ? 85.673  109.676 127.732 1.00 45.73  ? 660 TYR A CB    1 
ATOM   4205  C  CG    . TYR A 1 668 ? 87.084  110.167 127.515 1.00 44.66  ? 660 TYR A CG    1 
ATOM   4206  C  CD1   . TYR A 1 668 ? 87.653  110.159 126.250 1.00 46.88  ? 660 TYR A CD1   1 
ATOM   4207  C  CD2   . TYR A 1 668 ? 87.838  110.660 128.568 1.00 46.26  ? 660 TYR A CD2   1 
ATOM   4208  C  CE1   . TYR A 1 668 ? 88.935  110.618 126.043 1.00 44.50  ? 660 TYR A CE1   1 
ATOM   4209  C  CE2   . TYR A 1 668 ? 89.123  111.121 128.369 1.00 47.09  ? 660 TYR A CE2   1 
ATOM   4210  C  CZ    . TYR A 1 668 ? 89.666  111.097 127.105 1.00 42.42  ? 660 TYR A CZ    1 
ATOM   4211  O  OH    . TYR A 1 668 ? 90.945  111.557 126.899 1.00 43.13  ? 660 TYR A OH    1 
ATOM   4212  N  N     . VAL A 1 669 ? 82.422  110.411 126.589 1.00 44.51  ? 661 VAL A N     1 
ATOM   4213  C  CA    . VAL A 1 669 ? 80.973  110.298 126.674 1.00 43.85  ? 661 VAL A CA    1 
ATOM   4214  C  C     . VAL A 1 669 ? 80.479  109.143 125.816 1.00 45.20  ? 661 VAL A C     1 
ATOM   4215  O  O     . VAL A 1 669 ? 81.012  108.875 124.733 1.00 46.20  ? 661 VAL A O     1 
ATOM   4216  C  CB    . VAL A 1 669 ? 80.288  111.615 126.254 1.00 43.84  ? 661 VAL A CB    1 
ATOM   4217  C  CG1   . VAL A 1 669 ? 80.603  112.714 127.253 1.00 44.70  ? 661 VAL A CG1   1 
ATOM   4218  C  CG2   . VAL A 1 669 ? 80.733  112.026 124.862 1.00 46.27  ? 661 VAL A CG2   1 
ATOM   4219  N  N     . VAL A 1 670 ? 79.464  108.453 126.324 1.00 43.84  ? 662 VAL A N     1 
ATOM   4220  C  CA    . VAL A 1 670 ? 78.630  107.549 125.546 1.00 47.07  ? 662 VAL A CA    1 
ATOM   4221  C  C     . VAL A 1 670 ? 77.393  108.325 125.123 1.00 48.74  ? 662 VAL A C     1 
ATOM   4222  O  O     . VAL A 1 670 ? 76.706  108.917 125.968 1.00 51.44  ? 662 VAL A O     1 
ATOM   4223  C  CB    . VAL A 1 670 ? 78.246  106.302 126.359 1.00 44.45  ? 662 VAL A CB    1 
ATOM   4224  C  CG1   . VAL A 1 670 ? 77.439  105.340 125.504 1.00 45.10  ? 662 VAL A CG1   1 
ATOM   4225  C  CG2   . VAL A 1 670 ? 79.484  105.628 126.911 1.00 45.92  ? 662 VAL A CG2   1 
ATOM   4226  N  N     . VAL A 1 671 ? 77.125  108.345 123.818 1.00 52.13  ? 663 VAL A N     1 
ATOM   4227  C  CA    . VAL A 1 671 ? 76.055  109.133 123.223 1.00 53.24  ? 663 VAL A CA    1 
ATOM   4228  C  C     . VAL A 1 671 ? 75.333  108.274 122.192 1.00 54.99  ? 663 VAL A C     1 
ATOM   4229  O  O     . VAL A 1 671 ? 75.653  107.099 121.995 1.00 53.32  ? 663 VAL A O     1 
ATOM   4230  C  CB    . VAL A 1 671 ? 76.580  110.428 122.571 1.00 49.02  ? 663 VAL A CB    1 
ATOM   4231  C  CG1   . VAL A 1 671 ? 77.102  111.384 123.625 1.00 49.85  ? 663 VAL A CG1   1 
ATOM   4232  C  CG2   . VAL A 1 671 ? 77.670  110.102 121.570 1.00 52.20  ? 663 VAL A CG2   1 
ATOM   4233  N  N     . ARG A 1 672 ? 74.349  108.874 121.527 1.00 58.54  ? 664 ARG A N     1 
ATOM   4234  C  CA    . ARG A 1 672 ? 73.609  108.201 120.472 1.00 64.46  ? 664 ARG A CA    1 
ATOM   4235  C  C     . ARG A 1 672 ? 74.396  108.241 119.164 1.00 67.11  ? 664 ARG A C     1 
ATOM   4236  O  O     . ARG A 1 672 ? 75.461  108.856 119.061 1.00 70.39  ? 664 ARG A O     1 
ATOM   4237  C  CB    . ARG A 1 672 ? 72.235  108.837 120.292 1.00 64.79  ? 664 ARG A CB    1 
ATOM   4238  C  CG    . ARG A 1 672 ? 71.344  108.766 121.514 1.00 73.05  ? 664 ARG A CG    1 
ATOM   4239  C  CD    . ARG A 1 672 ? 69.992  109.393 121.225 1.00 83.03  ? 664 ARG A CD    1 
ATOM   4240  N  NE    . ARG A 1 672 ? 70.125  110.751 120.712 1.00 83.58  ? 664 ARG A NE    1 
ATOM   4241  C  CZ    . ARG A 1 672 ? 69.106  111.515 120.344 1.00 86.05  ? 664 ARG A CZ    1 
ATOM   4242  N  NH1   . ARG A 1 672 ? 67.858  111.085 120.418 1.00 90.73  ? 664 ARG A NH1   1 
ATOM   4243  N  NH2   . ARG A 1 672 ? 69.346  112.741 119.889 1.00 83.75  ? 664 ARG A NH2   1 
ATOM   4244  N  N     . ARG A 1 673 ? 73.855  107.576 118.141 1.00 61.06  ? 665 ARG A N     1 
ATOM   4245  C  CA    . ARG A 1 673 ? 74.533  107.524 116.850 1.00 55.97  ? 665 ARG A CA    1 
ATOM   4246  C  C     . ARG A 1 673 ? 74.526  108.883 116.161 1.00 61.70  ? 665 ARG A C     1 
ATOM   4247  O  O     . ARG A 1 673 ? 75.480  109.231 115.456 1.00 61.15  ? 665 ARG A O     1 
ATOM   4248  C  CB    . ARG A 1 673 ? 73.879  106.467 115.962 1.00 61.31  ? 665 ARG A CB    1 
ATOM   4249  C  CG    . ARG A 1 673 ? 74.638  106.171 114.684 1.00 61.59  ? 665 ARG A CG    1 
ATOM   4250  C  CD    . ARG A 1 673 ? 74.045  104.975 113.962 1.00 62.28  ? 665 ARG A CD    1 
ATOM   4251  N  NE    . ARG A 1 673 ? 74.851  104.582 112.812 1.00 65.95  ? 665 ARG A NE    1 
ATOM   4252  C  CZ    . ARG A 1 673 ? 74.618  103.510 112.068 1.00 68.06  ? 665 ARG A CZ    1 
ATOM   4253  N  NH1   . ARG A 1 673 ? 73.608  102.696 112.325 1.00 73.44  ? 665 ARG A NH1   1 
ATOM   4254  N  NH2   . ARG A 1 673 ? 75.421  103.247 111.042 1.00 64.90  ? 665 ARG A NH2   1 
ATOM   4255  N  N     . ASP A 1 674 ? 73.466  109.670 116.360 1.00 65.51  ? 666 ASP A N     1 
ATOM   4256  C  CA    . ASP A 1 674 ? 73.295  110.948 115.677 1.00 64.05  ? 666 ASP A CA    1 
ATOM   4257  C  C     . ASP A 1 674 ? 73.929  112.111 116.431 1.00 66.54  ? 666 ASP A C     1 
ATOM   4258  O  O     . ASP A 1 674 ? 73.482  113.256 116.284 1.00 63.84  ? 666 ASP A O     1 
ATOM   4259  C  CB    . ASP A 1 674 ? 71.810  111.218 115.433 1.00 66.91  ? 666 ASP A CB    1 
ATOM   4260  C  CG    . ASP A 1 674 ? 71.008  111.256 116.715 1.00 79.03  ? 666 ASP A CG    1 
ATOM   4261  O  OD1   . ASP A 1 674 ? 71.343  110.497 117.648 1.00 79.32  ? 666 ASP A OD1   1 
ATOM   4262  O  OD2   . ASP A 1 674 ? 70.043  112.045 116.792 1.00 82.80  ? 666 ASP A OD2   1 
ATOM   4263  N  N     . CYS A 1 675 ? 74.948  111.847 117.238 1.00 66.70  ? 667 CYS A N     1 
ATOM   4264  C  CA    . CYS A 1 675 ? 75.642  112.915 117.939 1.00 59.66  ? 667 CYS A CA    1 
ATOM   4265  C  C     . CYS A 1 675 ? 76.303  113.856 116.933 1.00 58.91  ? 667 CYS A C     1 
ATOM   4266  O  O     . CYS A 1 675 ? 76.755  113.409 115.872 1.00 63.79  ? 667 CYS A O     1 
ATOM   4267  C  CB    . CYS A 1 675 ? 76.690  112.324 118.885 1.00 58.43  ? 667 CYS A CB    1 
ATOM   4268  S  SG    . CYS A 1 675 ? 77.987  113.454 119.439 1.00 67.50  ? 667 CYS A SG    1 
ATOM   4269  N  N     . PRO A 1 676 ? 76.355  115.157 117.216 1.00 55.35  ? 668 PRO A N     1 
ATOM   4270  C  CA    . PRO A 1 676 ? 77.023  116.084 116.294 1.00 52.50  ? 668 PRO A CA    1 
ATOM   4271  C  C     . PRO A 1 676 ? 78.487  115.721 116.098 1.00 51.88  ? 668 PRO A C     1 
ATOM   4272  O  O     . PRO A 1 676 ? 79.164  115.258 117.017 1.00 52.62  ? 668 PRO A O     1 
ATOM   4273  C  CB    . PRO A 1 676 ? 76.865  117.447 116.979 1.00 54.98  ? 668 PRO A CB    1 
ATOM   4274  C  CG    . PRO A 1 676 ? 76.508  117.138 118.398 1.00 58.51  ? 668 PRO A CG    1 
ATOM   4275  C  CD    . PRO A 1 676 ? 75.732  115.863 118.346 1.00 58.70  ? 668 PRO A CD    1 
ATOM   4276  N  N     . GLU A 1 677 ? 78.969  115.934 114.878 1.00 51.49  ? 669 GLU A N     1 
ATOM   4277  C  CA    . GLU A 1 677 ? 80.318  115.546 114.506 1.00 53.29  ? 669 GLU A CA    1 
ATOM   4278  C  C     . GLU A 1 677 ? 81.345  116.533 115.052 1.00 47.39  ? 669 GLU A C     1 
ATOM   4279  O  O     . GLU A 1 677 ? 81.025  117.658 115.443 1.00 47.66  ? 669 GLU A O     1 
ATOM   4280  C  CB    . GLU A 1 677 ? 80.445  115.452 112.986 1.00 56.02  ? 669 GLU A CB    1 
ATOM   4281  C  CG    . GLU A 1 677 ? 79.501  114.450 112.345 1.00 62.46  ? 669 GLU A CG    1 
ATOM   4282  C  CD    . GLU A 1 677 ? 79.629  114.415 110.835 1.00 78.67  ? 669 GLU A CD    1 
ATOM   4283  O  OE1   . GLU A 1 677 ? 80.342  115.276 110.279 1.00 81.35  ? 669 GLU A OE1   1 
ATOM   4284  O  OE2   . GLU A 1 677 ? 79.017  113.528 110.205 1.00 85.07  ? 669 GLU A OE2   1 
ATOM   4285  N  N     . TYR A 1 678 ? 82.598  116.089 115.074 1.00 47.08  ? 670 TYR A N     1 
ATOM   4286  C  CA    . TYR A 1 678 ? 83.703  116.948 115.463 1.00 46.71  ? 670 TYR A CA    1 
ATOM   4287  C  C     . TYR A 1 678 ? 83.990  117.971 114.369 1.00 48.80  ? 670 TYR A C     1 
ATOM   4288  O  O     . TYR A 1 678 ? 83.654  117.780 113.197 1.00 50.99  ? 670 TYR A O     1 
ATOM   4289  C  CB    . TYR A 1 678 ? 84.958  116.119 115.742 1.00 49.00  ? 670 TYR A CB    1 
ATOM   4290  C  CG    . TYR A 1 678 ? 84.889  115.274 116.995 1.00 48.09  ? 670 TYR A CG    1 
ATOM   4291  C  CD1   . TYR A 1 678 ? 84.042  114.177 117.074 1.00 47.39  ? 670 TYR A CD1   1 
ATOM   4292  C  CD2   . TYR A 1 678 ? 85.684  115.564 118.093 1.00 47.26  ? 670 TYR A CD2   1 
ATOM   4293  C  CE1   . TYR A 1 678 ? 83.979  113.405 118.214 1.00 45.80  ? 670 TYR A CE1   1 
ATOM   4294  C  CE2   . TYR A 1 678 ? 85.630  114.794 119.236 1.00 51.01  ? 670 TYR A CE2   1 
ATOM   4295  C  CZ    . TYR A 1 678 ? 84.775  113.716 119.290 1.00 49.82  ? 670 TYR A CZ    1 
ATOM   4296  O  OH    . TYR A 1 678 ? 84.717  112.946 120.427 1.00 53.05  ? 670 TYR A OH    1 
ATOM   4297  N  N     . ASP A 1 679 ? 84.620  119.071 114.764 1.00 51.94  ? 671 ASP A N     1 
ATOM   4298  C  CA    . ASP A 1 679 ? 85.007  120.117 113.828 1.00 55.44  ? 671 ASP A CA    1 
ATOM   4299  C  C     . ASP A 1 679 ? 86.355  119.754 113.220 1.00 52.90  ? 671 ASP A C     1 
ATOM   4300  O  O     . ASP A 1 679 ? 87.345  119.603 113.942 1.00 56.40  ? 671 ASP A O     1 
ATOM   4301  C  CB    . ASP A 1 679 ? 85.073  121.473 114.528 1.00 65.29  ? 671 ASP A CB    1 
ATOM   4302  C  CG    . ASP A 1 679 ? 85.083  122.636 113.554 1.00 69.70  ? 671 ASP A CG    1 
ATOM   4303  O  OD1   . ASP A 1 679 ? 85.606  122.480 112.431 1.00 65.38  ? 671 ASP A OD1   1 
ATOM   4304  O  OD2   . ASP A 1 679 ? 84.565  123.714 113.913 1.00 74.40  ? 671 ASP A OD2   1 
ATOM   4305  N  N     . ARG A 1 680 ? 86.394  119.628 111.893 1.00 51.89  ? 672 ARG A N     1 
ATOM   4306  C  CA    . ARG A 1 680 ? 87.609  119.206 111.208 1.00 55.06  ? 672 ARG A CA    1 
ATOM   4307  C  C     . ARG A 1 680 ? 88.676  120.290 111.152 1.00 58.90  ? 672 ARG A C     1 
ATOM   4308  O  O     . ARG A 1 680 ? 89.793  120.006 110.708 1.00 64.41  ? 672 ARG A O     1 
ATOM   4309  C  CB    . ARG A 1 680 ? 87.283  118.745 109.788 1.00 51.34  ? 672 ARG A CB    1 
ATOM   4310  C  CG    . ARG A 1 680 ? 86.656  117.369 109.704 1.00 48.81  ? 672 ARG A CG    1 
ATOM   4311  C  CD    . ARG A 1 680 ? 86.629  116.888 108.267 1.00 53.36  ? 672 ARG A CD    1 
ATOM   4312  N  NE    . ARG A 1 680 ? 87.925  117.070 107.623 1.00 62.14  ? 672 ARG A NE    1 
ATOM   4313  C  CZ    . ARG A 1 680 ? 88.185  116.765 106.359 1.00 65.39  ? 672 ARG A CZ    1 
ATOM   4314  N  NH1   . ARG A 1 680 ? 87.259  116.247 105.569 1.00 65.59  ? 672 ARG A NH1   1 
ATOM   4315  N  NH2   . ARG A 1 680 ? 89.404  116.986 105.877 1.00 63.47  ? 672 ARG A NH2   1 
ATOM   4316  N  N     . ARG A 1 681 ? 88.367  121.516 111.576 1.00 55.38  ? 673 ARG A N     1 
ATOM   4317  C  CA    . ARG A 1 681 ? 89.349  122.591 111.516 1.00 57.26  ? 673 ARG A CA    1 
ATOM   4318  C  C     . ARG A 1 681 ? 90.502  122.397 112.489 1.00 59.34  ? 673 ARG A C     1 
ATOM   4319  O  O     . ARG A 1 681 ? 91.524  123.077 112.350 1.00 59.27  ? 673 ARG A O     1 
ATOM   4320  C  CB    . ARG A 1 681 ? 88.674  123.935 111.786 1.00 62.50  ? 673 ARG A CB    1 
ATOM   4321  C  CG    . ARG A 1 681 ? 88.289  124.154 113.235 1.00 65.18  ? 673 ARG A CG    1 
ATOM   4322  C  CD    . ARG A 1 681 ? 87.565  125.472 113.411 1.00 69.42  ? 673 ARG A CD    1 
ATOM   4323  N  NE    . ARG A 1 681 ? 86.289  125.481 112.708 1.00 72.11  ? 673 ARG A NE    1 
ATOM   4324  C  CZ    . ARG A 1 681 ? 85.491  126.536 112.619 1.00 79.51  ? 673 ARG A CZ    1 
ATOM   4325  N  NH1   . ARG A 1 681 ? 85.814  127.694 113.169 1.00 83.96  ? 673 ARG A NH1   1 
ATOM   4326  N  NH2   . ARG A 1 681 ? 84.342  126.427 111.959 1.00 82.55  ? 673 ARG A NH2   1 
ATOM   4327  N  N     . PHE A 1 682 ? 90.370  121.496 113.460 1.00 63.50  ? 674 PHE A N     1 
ATOM   4328  C  CA    . PHE A 1 682 ? 91.405  121.255 114.456 1.00 63.79  ? 674 PHE A CA    1 
ATOM   4329  C  C     . PHE A 1 682 ? 92.205  120.021 114.058 1.00 61.60  ? 674 PHE A C     1 
ATOM   4330  O  O     . PHE A 1 682 ? 91.637  118.942 113.865 1.00 57.66  ? 674 PHE A O     1 
ATOM   4331  C  CB    . PHE A 1 682 ? 90.797  121.072 115.845 1.00 59.75  ? 674 PHE A CB    1 
ATOM   4332  C  CG    . PHE A 1 682 ? 90.021  122.260 116.328 1.00 57.85  ? 674 PHE A CG    1 
ATOM   4333  C  CD1   . PHE A 1 682 ? 90.674  123.393 116.779 1.00 61.90  ? 674 PHE A CD1   1 
ATOM   4334  C  CD2   . PHE A 1 682 ? 88.639  122.241 116.339 1.00 57.06  ? 674 PHE A CD2   1 
ATOM   4335  C  CE1   . PHE A 1 682 ? 89.963  124.486 117.225 1.00 66.78  ? 674 PHE A CE1   1 
ATOM   4336  C  CE2   . PHE A 1 682 ? 87.923  123.332 116.786 1.00 63.94  ? 674 PHE A CE2   1 
ATOM   4337  C  CZ    . PHE A 1 682 ? 88.587  124.456 117.229 1.00 67.14  ? 674 PHE A CZ    1 
ATOM   4338  N  N     . VAL A 1 683 ? 93.522  120.186 113.940 1.00 65.84  ? 675 VAL A N     1 
ATOM   4339  C  CA    . VAL A 1 683 ? 94.427  119.098 113.602 1.00 70.17  ? 675 VAL A CA    1 
ATOM   4340  C  C     . VAL A 1 683 ? 95.590  119.114 114.583 1.00 76.54  ? 675 VAL A C     1 
ATOM   4341  O  O     . VAL A 1 683 ? 95.935  120.146 115.161 1.00 82.25  ? 675 VAL A O     1 
ATOM   4342  C  CB    . VAL A 1 683 ? 94.943  119.195 112.151 1.00 71.93  ? 675 VAL A CB    1 
ATOM   4343  C  CG1   . VAL A 1 683 ? 93.820  118.910 111.167 1.00 68.01  ? 675 VAL A CG1   1 
ATOM   4344  C  CG2   . VAL A 1 683 ? 95.544  120.567 111.897 1.00 75.21  ? 675 VAL A CG2   1 
ATOM   4345  N  N     . GLY A 1 684 ? 96.197  117.949 114.762 1.00 74.77  ? 676 GLY A N     1 
ATOM   4346  C  CA    . GLY A 1 684 ? 97.312  117.838 115.690 1.00 81.30  ? 676 GLY A CA    1 
ATOM   4347  C  C     . GLY A 1 684 ? 96.826  117.540 117.090 1.00 83.24  ? 676 GLY A C     1 
ATOM   4348  O  O     . GLY A 1 684 ? 96.092  116.576 117.314 1.00 82.07  ? 676 GLY A O     1 
ATOM   4349  N  N     . PHE A 1 685 ? 97.241  118.370 118.044 1.00 85.93  ? 677 PHE A N     1 
ATOM   4350  C  CA    . PHE A 1 685 ? 96.895  118.193 119.447 1.00 86.95  ? 677 PHE A CA    1 
ATOM   4351  C  C     . PHE A 1 685 ? 96.396  119.507 120.029 1.00 84.04  ? 677 PHE A C     1 
ATOM   4352  O  O     . PHE A 1 685 ? 96.970  120.569 119.769 1.00 86.71  ? 677 PHE A O     1 
ATOM   4353  C  CB    . PHE A 1 685 ? 98.100  117.684 120.250 1.00 91.26  ? 677 PHE A CB    1 
ATOM   4354  C  CG    . PHE A 1 685 ? 97.964  117.871 121.733 1.00 96.61  ? 677 PHE A CG    1 
ATOM   4355  C  CD1   . PHE A 1 685 ? 97.075  117.100 122.463 1.00 98.71  ? 677 PHE A CD1   1 
ATOM   4356  C  CD2   . PHE A 1 685 ? 98.731  118.813 122.398 1.00 96.03  ? 677 PHE A CD2   1 
ATOM   4357  C  CE1   . PHE A 1 685 ? 96.949  117.269 123.828 1.00 96.87  ? 677 PHE A CE1   1 
ATOM   4358  C  CE2   . PHE A 1 685 ? 98.610  118.987 123.763 1.00 97.17  ? 677 PHE A CE2   1 
ATOM   4359  C  CZ    . PHE A 1 685 ? 97.718  118.214 124.479 1.00 97.99  ? 677 PHE A CZ    1 
ATOM   4360  N  N     . GLY A 1 686 ? 95.326  119.430 120.814 1.00 77.19  ? 678 GLY A N     1 
ATOM   4361  C  CA    . GLY A 1 686 ? 94.834  120.624 121.501 1.00 76.25  ? 678 GLY A CA    1 
ATOM   4362  C  C     . GLY A 1 686 ? 93.462  121.050 121.019 1.00 74.28  ? 678 GLY A C     1 
ATOM   4363  O  O     . GLY A 1 686 ? 93.212  121.214 119.825 1.00 77.37  ? 678 GLY A O     1 
ATOM   4364  N  N     . TRP A 1 687 ? 92.553  121.225 121.977 1.00 69.07  ? 679 TRP A N     1 
ATOM   4365  C  CA    . TRP A 1 687 ? 91.197  121.722 121.759 1.00 62.89  ? 679 TRP A CA    1 
ATOM   4366  C  C     . TRP A 1 687 ? 90.366  120.825 120.852 1.00 61.71  ? 679 TRP A C     1 
ATOM   4367  O  O     . TRP A 1 687 ? 89.334  121.265 120.334 1.00 64.99  ? 679 TRP A O     1 
ATOM   4368  C  CB    . TRP A 1 687 ? 91.211  123.149 121.198 1.00 65.00  ? 679 TRP A CB    1 
ATOM   4369  C  CG    . TRP A 1 687 ? 90.879  124.189 122.211 1.00 69.37  ? 679 TRP A CG    1 
ATOM   4370  C  CD1   . TRP A 1 687 ? 91.730  124.762 123.108 1.00 74.13  ? 679 TRP A CD1   1 
ATOM   4371  C  CD2   . TRP A 1 687 ? 89.599  124.787 122.433 1.00 73.21  ? 679 TRP A CD2   1 
ATOM   4372  N  NE1   . TRP A 1 687 ? 91.058  125.680 123.878 1.00 79.08  ? 679 TRP A NE1   1 
ATOM   4373  C  CE2   . TRP A 1 687 ? 89.747  125.714 123.482 1.00 81.24  ? 679 TRP A CE2   1 
ATOM   4374  C  CE3   . TRP A 1 687 ? 88.341  124.628 121.846 1.00 71.01  ? 679 TRP A CE3   1 
ATOM   4375  C  CZ2   . TRP A 1 687 ? 88.685  126.477 123.957 1.00 86.30  ? 679 TRP A CZ2   1 
ATOM   4376  C  CZ3   . TRP A 1 687 ? 87.290  125.388 122.317 1.00 76.22  ? 679 TRP A CZ3   1 
ATOM   4377  C  CH2   . TRP A 1 687 ? 87.468  126.301 123.362 1.00 84.74  ? 679 TRP A CH2   1 
ATOM   4378  N  N     . ASN A 1 688 ? 90.783  119.576 120.644 1.00 61.44  ? 680 ASN A N     1 
ATOM   4379  C  CA    . ASN A 1 688 ? 90.050  118.696 119.742 1.00 55.16  ? 680 ASN A CA    1 
ATOM   4380  C  C     . ASN A 1 688 ? 88.708  118.283 120.337 1.00 55.26  ? 680 ASN A C     1 
ATOM   4381  O  O     . ASN A 1 688 ? 87.670  118.373 119.673 1.00 56.27  ? 680 ASN A O     1 
ATOM   4382  C  CB    . ASN A 1 688 ? 90.899  117.469 119.415 1.00 57.15  ? 680 ASN A CB    1 
ATOM   4383  C  CG    . ASN A 1 688 ? 92.303  117.836 118.988 1.00 63.24  ? 680 ASN A CG    1 
ATOM   4384  O  OD1   . ASN A 1 688 ? 93.282  117.393 119.587 1.00 63.52  ? 680 ASN A OD1   1 
ATOM   4385  N  ND2   . ASN A 1 688 ? 92.411  118.655 117.950 1.00 68.12  ? 680 ASN A ND2   1 
ATOM   4386  N  N     . LYS A 1 689 ? 88.709  117.833 121.593 1.00 55.24  ? 681 LYS A N     1 
ATOM   4387  C  CA    . LYS A 1 689 ? 87.476  117.400 122.239 1.00 52.97  ? 681 LYS A CA    1 
ATOM   4388  C  C     . LYS A 1 689 ? 86.738  118.540 122.924 1.00 54.65  ? 681 LYS A C     1 
ATOM   4389  O  O     . LYS A 1 689 ? 85.535  118.415 123.181 1.00 56.84  ? 681 LYS A O     1 
ATOM   4390  C  CB    . LYS A 1 689 ? 87.776  116.300 123.260 1.00 49.57  ? 681 LYS A CB    1 
ATOM   4391  C  CG    . LYS A 1 689 ? 88.264  115.005 122.646 1.00 52.35  ? 681 LYS A CG    1 
ATOM   4392  C  CD    . LYS A 1 689 ? 88.722  114.024 123.712 1.00 56.70  ? 681 LYS A CD    1 
ATOM   4393  C  CE    . LYS A 1 689 ? 89.943  114.546 124.450 1.00 58.53  ? 681 LYS A CE    1 
ATOM   4394  N  NZ    . LYS A 1 689 ? 90.482  113.550 125.415 1.00 55.58  ? 681 LYS A NZ    1 
ATOM   4395  N  N     . VAL A 1 690 ? 87.429  119.640 123.228 1.00 55.67  ? 682 VAL A N     1 
ATOM   4396  C  CA    . VAL A 1 690 ? 86.778  120.770 123.882 1.00 62.01  ? 682 VAL A CA    1 
ATOM   4397  C  C     . VAL A 1 690 ? 85.689  121.344 122.988 1.00 63.28  ? 682 VAL A C     1 
ATOM   4398  O  O     . VAL A 1 690 ? 84.584  121.657 123.450 1.00 64.64  ? 682 VAL A O     1 
ATOM   4399  C  CB    . VAL A 1 690 ? 87.819  121.839 124.262 1.00 64.60  ? 682 VAL A CB    1 
ATOM   4400  C  CG1   . VAL A 1 690 ? 87.161  122.969 125.036 1.00 65.49  ? 682 VAL A CG1   1 
ATOM   4401  C  CG2   . VAL A 1 690 ? 88.949  121.219 125.067 1.00 58.17  ? 682 VAL A CG2   1 
ATOM   4402  N  N     . ALA A 1 691 ? 85.981  121.488 121.694 1.00 58.52  ? 683 ALA A N     1 
ATOM   4403  C  CA    . ALA A 1 691 ? 84.990  122.011 120.761 1.00 59.11  ? 683 ALA A CA    1 
ATOM   4404  C  C     . ALA A 1 691 ? 83.779  121.093 120.667 1.00 58.61  ? 683 ALA A C     1 
ATOM   4405  O  O     . ALA A 1 691 ? 82.635  121.563 120.637 1.00 64.95  ? 683 ALA A O     1 
ATOM   4406  C  CB    . ALA A 1 691 ? 85.626  122.209 119.386 1.00 62.74  ? 683 ALA A CB    1 
ATOM   4407  N  N     . HIS A 1 692 ? 84.007  119.780 120.617 1.00 56.71  ? 684 HIS A N     1 
ATOM   4408  C  CA    . HIS A 1 692 ? 82.891  118.844 120.535 1.00 56.51  ? 684 HIS A CA    1 
ATOM   4409  C  C     . HIS A 1 692 ? 82.040  118.884 121.799 1.00 55.46  ? 684 HIS A C     1 
ATOM   4410  O  O     . HIS A 1 692 ? 80.809  118.817 121.726 1.00 55.64  ? 684 HIS A O     1 
ATOM   4411  C  CB    . HIS A 1 692 ? 83.404  117.430 120.276 1.00 50.22  ? 684 HIS A CB    1 
ATOM   4412  C  CG    . HIS A 1 692 ? 82.315  116.418 120.111 1.00 47.98  ? 684 HIS A CG    1 
ATOM   4413  N  ND1   . HIS A 1 692 ? 82.017  115.480 121.075 1.00 47.37  ? 684 HIS A ND1   1 
ATOM   4414  C  CD2   . HIS A 1 692 ? 81.446  116.202 119.096 1.00 48.13  ? 684 HIS A CD2   1 
ATOM   4415  C  CE1   . HIS A 1 692 ? 81.015  114.728 120.660 1.00 47.56  ? 684 HIS A CE1   1 
ATOM   4416  N  NE2   . HIS A 1 692 ? 80.649  115.145 119.461 1.00 48.86  ? 684 HIS A NE2   1 
ATOM   4417  N  N     . ILE A 1 693 ? 82.675  118.994 122.967 1.00 55.01  ? 685 ILE A N     1 
ATOM   4418  C  CA    . ILE A 1 693 ? 81.912  119.068 124.209 1.00 55.03  ? 685 ILE A CA    1 
ATOM   4419  C  C     . ILE A 1 693 ? 81.118  120.368 124.272 1.00 62.19  ? 685 ILE A C     1 
ATOM   4420  O  O     . ILE A 1 693 ? 79.975  120.392 124.745 1.00 65.71  ? 685 ILE A O     1 
ATOM   4421  C  CB    . ILE A 1 693 ? 82.845  118.904 125.421 1.00 54.60  ? 685 ILE A CB    1 
ATOM   4422  C  CG1   . ILE A 1 693 ? 83.484  117.515 125.408 1.00 49.39  ? 685 ILE A CG1   1 
ATOM   4423  C  CG2   . ILE A 1 693 ? 82.081  119.113 126.718 1.00 56.41  ? 685 ILE A CG2   1 
ATOM   4424  C  CD1   . ILE A 1 693 ? 82.482  116.385 125.389 1.00 44.54  ? 685 ILE A CD1   1 
ATOM   4425  N  N     . MET A 1 694 ? 81.705  121.469 123.793 1.00 63.38  ? 686 MET A N     1 
ATOM   4426  C  CA    . MET A 1 694 ? 80.970  122.728 123.737 1.00 63.87  ? 686 MET A CA    1 
ATOM   4427  C  C     . MET A 1 694 ? 79.766  122.622 122.811 1.00 63.94  ? 686 MET A C     1 
ATOM   4428  O  O     . MET A 1 694 ? 78.680  123.118 123.133 1.00 68.04  ? 686 MET A O     1 
ATOM   4429  C  CB    . MET A 1 694 ? 81.895  123.857 123.285 1.00 65.25  ? 686 MET A CB    1 
ATOM   4430  C  CG    . MET A 1 694 ? 82.908  124.281 124.329 1.00 72.34  ? 686 MET A CG    1 
ATOM   4431  S  SD    . MET A 1 694 ? 84.131  125.429 123.677 1.00 83.97  ? 686 MET A SD    1 
ATOM   4432  C  CE    . MET A 1 694 ? 83.074  126.683 122.962 1.00 82.62  ? 686 MET A CE    1 
ATOM   4433  N  N     . GLU A 1 695 ? 79.940  121.982 121.654 1.00 63.53  ? 687 GLU A N     1 
ATOM   4434  C  CA    . GLU A 1 695 ? 78.818  121.794 120.739 1.00 65.61  ? 687 GLU A CA    1 
ATOM   4435  C  C     . GLU A 1 695 ? 77.746  120.906 121.357 1.00 63.58  ? 687 GLU A C     1 
ATOM   4436  O  O     . GLU A 1 695 ? 76.549  121.119 121.133 1.00 67.84  ? 687 GLU A O     1 
ATOM   4437  C  CB    . GLU A 1 695 ? 79.308  121.208 119.416 1.00 65.97  ? 687 GLU A CB    1 
ATOM   4438  C  CG    . GLU A 1 695 ? 79.858  122.240 118.444 1.00 71.35  ? 687 GLU A CG    1 
ATOM   4439  C  CD    . GLU A 1 695 ? 78.764  123.023 117.738 1.00 81.59  ? 687 GLU A CD    1 
ATOM   4440  O  OE1   . GLU A 1 695 ? 77.574  122.693 117.926 1.00 82.29  ? 687 GLU A OE1   1 
ATOM   4441  O  OE2   . GLU A 1 695 ? 79.095  123.967 116.990 1.00 86.26  ? 687 GLU A OE2   1 
ATOM   4442  N  N     . LEU A 1 696 ? 78.155  119.893 122.121 1.00 61.62  ? 688 LEU A N     1 
ATOM   4443  C  CA    . LEU A 1 696 ? 77.182  119.070 122.830 1.00 61.58  ? 688 LEU A CA    1 
ATOM   4444  C  C     . LEU A 1 696 ? 76.401  119.895 123.843 1.00 63.16  ? 688 LEU A C     1 
ATOM   4445  O  O     . LEU A 1 696 ? 75.175  119.775 123.941 1.00 66.76  ? 688 LEU A O     1 
ATOM   4446  C  CB    . LEU A 1 696 ? 77.883  117.905 123.527 1.00 59.26  ? 688 LEU A CB    1 
ATOM   4447  C  CG    . LEU A 1 696 ? 78.441  116.781 122.657 1.00 54.02  ? 688 LEU A CG    1 
ATOM   4448  C  CD1   . LEU A 1 696 ? 79.194  115.786 123.519 1.00 48.69  ? 688 LEU A CD1   1 
ATOM   4449  C  CD2   . LEU A 1 696 ? 77.323  116.093 121.899 1.00 59.76  ? 688 LEU A CD2   1 
ATOM   4450  N  N     . ASP A 1 697 ? 77.095  120.742 124.603 1.00 63.87  ? 689 ASP A N     1 
ATOM   4451  C  CA    . ASP A 1 697 ? 76.421  121.536 125.624 1.00 65.28  ? 689 ASP A CA    1 
ATOM   4452  C  C     . ASP A 1 697 ? 75.476  122.559 125.005 1.00 70.83  ? 689 ASP A C     1 
ATOM   4453  O  O     . ASP A 1 697 ? 74.380  122.792 125.526 1.00 73.56  ? 689 ASP A O     1 
ATOM   4454  C  CB    . ASP A 1 697 ? 77.445  122.231 126.518 1.00 68.64  ? 689 ASP A CB    1 
ATOM   4455  C  CG    . ASP A 1 697 ? 76.794  123.023 127.634 1.00 79.17  ? 689 ASP A CG    1 
ATOM   4456  O  OD1   . ASP A 1 697 ? 76.235  122.399 128.560 1.00 81.53  ? 689 ASP A OD1   1 
ATOM   4457  O  OD2   . ASP A 1 697 ? 76.833  124.270 127.583 1.00 79.70  ? 689 ASP A OD2   1 
ATOM   4458  N  N     . VAL A 1 698 ? 75.880  123.181 123.895 1.00 68.06  ? 690 VAL A N     1 
ATOM   4459  C  CA    . VAL A 1 698 ? 75.044  124.202 123.276 1.00 63.79  ? 690 VAL A CA    1 
ATOM   4460  C  C     . VAL A 1 698 ? 73.786  123.604 122.661 1.00 62.69  ? 690 VAL A C     1 
ATOM   4461  O  O     . VAL A 1 698 ? 72.823  124.334 122.400 1.00 67.49  ? 690 VAL A O     1 
ATOM   4462  C  CB    . VAL A 1 698 ? 75.848  124.994 122.227 1.00 67.40  ? 690 VAL A CB    1 
ATOM   4463  C  CG1   . VAL A 1 698 ? 75.915  124.237 120.913 1.00 68.58  ? 690 VAL A CG1   1 
ATOM   4464  C  CG2   . VAL A 1 698 ? 75.250  126.376 122.026 1.00 79.55  ? 690 VAL A CG2   1 
ATOM   4465  N  N     . GLN A 1 699 ? 73.759  122.292 122.427 1.00 61.39  ? 691 GLN A N     1 
ATOM   4466  C  CA    . GLN A 1 699 ? 72.580  121.612 121.912 1.00 64.44  ? 691 GLN A CA    1 
ATOM   4467  C  C     . GLN A 1 699 ? 71.758  120.964 123.018 1.00 64.37  ? 691 GLN A C     1 
ATOM   4468  O  O     . GLN A 1 699 ? 70.985  120.038 122.747 1.00 63.72  ? 691 GLN A O     1 
ATOM   4469  C  CB    . GLN A 1 699 ? 72.978  120.567 120.870 1.00 64.95  ? 691 GLN A CB    1 
ATOM   4470  C  CG    . GLN A 1 699 ? 73.622  121.149 119.626 1.00 68.33  ? 691 GLN A CG    1 
ATOM   4471  C  CD    . GLN A 1 699 ? 73.690  120.154 118.489 1.00 71.12  ? 691 GLN A CD    1 
ATOM   4472  O  OE1   . GLN A 1 699 ? 73.018  119.123 118.510 1.00 70.48  ? 691 GLN A OE1   1 
ATOM   4473  N  NE2   . GLN A 1 699 ? 74.505  120.457 117.486 1.00 76.56  ? 691 GLN A NE2   1 
ATOM   4474  N  N     . GLU A 1 700 ? 71.919  121.428 124.257 1.00 63.21  ? 692 GLU A N     1 
ATOM   4475  C  CA    . GLU A 1 700 ? 71.155  120.945 125.405 1.00 66.56  ? 692 GLU A CA    1 
ATOM   4476  C  C     . GLU A 1 700 ? 71.366  119.445 125.619 1.00 65.51  ? 692 GLU A C     1 
ATOM   4477  O  O     . GLU A 1 700 ? 70.433  118.642 125.574 1.00 68.32  ? 692 GLU A O     1 
ATOM   4478  C  CB    . GLU A 1 700 ? 69.668  121.281 125.256 1.00 73.38  ? 692 GLU A CB    1 
ATOM   4479  C  CG    . GLU A 1 700 ? 69.375  122.771 125.201 1.00 78.14  ? 692 GLU A CG    1 
ATOM   4480  C  CD    . GLU A 1 700 ? 67.891  123.068 125.122 1.00 85.64  ? 692 GLU A CD    1 
ATOM   4481  O  OE1   . GLU A 1 700 ? 67.092  122.109 125.114 1.00 87.13  ? 692 GLU A OE1   1 
ATOM   4482  O  OE2   . GLU A 1 700 ? 67.524  124.261 125.067 1.00 90.80  ? 692 GLU A OE2   1 
ATOM   4483  N  N     . TYR A 1 701 ? 72.622  119.081 125.849 1.00 63.97  ? 693 TYR A N     1 
ATOM   4484  C  CA    . TYR A 1 701 ? 72.984  117.731 126.255 1.00 64.63  ? 693 TYR A CA    1 
ATOM   4485  C  C     . TYR A 1 701 ? 73.297  117.719 127.744 1.00 64.67  ? 693 TYR A C     1 
ATOM   4486  O  O     . TYR A 1 701 ? 74.037  118.573 128.241 1.00 61.52  ? 693 TYR A O     1 
ATOM   4487  C  CB    . TYR A 1 701 ? 74.189  117.212 125.466 1.00 63.57  ? 693 TYR A CB    1 
ATOM   4488  C  CG    . TYR A 1 701 ? 73.834  116.505 124.178 1.00 62.37  ? 693 TYR A CG    1 
ATOM   4489  C  CD1   . TYR A 1 701 ? 73.354  115.203 124.189 1.00 64.13  ? 693 TYR A CD1   1 
ATOM   4490  C  CD2   . TYR A 1 701 ? 73.993  117.132 122.951 1.00 61.86  ? 693 TYR A CD2   1 
ATOM   4491  C  CE1   . TYR A 1 701 ? 73.033  114.550 123.016 1.00 67.80  ? 693 TYR A CE1   1 
ATOM   4492  C  CE2   . TYR A 1 701 ? 73.675  116.487 121.773 1.00 64.91  ? 693 TYR A CE2   1 
ATOM   4493  C  CZ    . TYR A 1 701 ? 73.196  115.197 121.812 1.00 68.82  ? 693 TYR A CZ    1 
ATOM   4494  O  OH    . TYR A 1 701 ? 72.877  114.550 120.641 1.00 69.95  ? 693 TYR A OH    1 
ATOM   4495  N  N     . GLU A 1 702 ? 72.726  116.750 128.453 1.00 68.23  ? 694 GLU A N     1 
ATOM   4496  C  CA    . GLU A 1 702 ? 72.940  116.613 129.887 1.00 67.19  ? 694 GLU A CA    1 
ATOM   4497  C  C     . GLU A 1 702 ? 74.136  115.703 130.130 1.00 62.97  ? 694 GLU A C     1 
ATOM   4498  O  O     . GLU A 1 702 ? 74.152  114.554 129.676 1.00 64.54  ? 694 GLU A O     1 
ATOM   4499  C  CB    . GLU A 1 702 ? 71.694  116.054 130.572 1.00 70.24  ? 694 GLU A CB    1 
ATOM   4500  C  CG    . GLU A 1 702 ? 70.467  116.939 130.456 1.00 77.31  ? 694 GLU A CG    1 
ATOM   4501  C  CD    . GLU A 1 702 ? 69.303  116.423 131.277 1.00 85.95  ? 694 GLU A CD    1 
ATOM   4502  O  OE1   . GLU A 1 702 ? 69.525  115.548 132.140 1.00 83.49  ? 694 GLU A OE1   1 
ATOM   4503  O  OE2   . GLU A 1 702 ? 68.165  116.890 131.058 1.00 88.55  ? 694 GLU A OE2   1 
ATOM   4504  N  N     . PHE A 1 703 ? 75.133  116.214 130.846 1.00 55.12  ? 695 PHE A N     1 
ATOM   4505  C  CA    . PHE A 1 703 ? 76.311  115.427 131.179 1.00 51.78  ? 695 PHE A CA    1 
ATOM   4506  C  C     . PHE A 1 703 ? 76.031  114.613 132.436 1.00 54.17  ? 695 PHE A C     1 
ATOM   4507  O  O     . PHE A 1 703 ? 75.773  115.177 133.504 1.00 59.73  ? 695 PHE A O     1 
ATOM   4508  C  CB    . PHE A 1 703 ? 77.521  116.335 131.375 1.00 49.48  ? 695 PHE A CB    1 
ATOM   4509  C  CG    . PHE A 1 703 ? 77.869  117.149 130.163 1.00 48.37  ? 695 PHE A CG    1 
ATOM   4510  C  CD1   . PHE A 1 703 ? 78.349  116.537 129.018 1.00 48.01  ? 695 PHE A CD1   1 
ATOM   4511  C  CD2   . PHE A 1 703 ? 77.726  118.524 130.172 1.00 49.31  ? 695 PHE A CD2   1 
ATOM   4512  C  CE1   . PHE A 1 703 ? 78.672  117.282 127.902 1.00 46.74  ? 695 PHE A CE1   1 
ATOM   4513  C  CE2   . PHE A 1 703 ? 78.048  119.275 129.060 1.00 54.93  ? 695 PHE A CE2   1 
ATOM   4514  C  CZ    . PHE A 1 703 ? 78.522  118.653 127.924 1.00 54.05  ? 695 PHE A CZ    1 
ATOM   4515  N  N     . ILE A 1 704 ? 76.071  113.290 132.305 1.00 54.79  ? 696 ILE A N     1 
ATOM   4516  C  CA    . ILE A 1 704 ? 75.765  112.370 133.394 1.00 54.10  ? 696 ILE A CA    1 
ATOM   4517  C  C     . ILE A 1 704 ? 76.999  111.524 133.666 1.00 56.30  ? 696 ILE A C     1 
ATOM   4518  O  O     . ILE A 1 704 ? 77.564  110.928 132.743 1.00 62.89  ? 696 ILE A O     1 
ATOM   4519  C  CB    . ILE A 1 704 ? 74.560  111.473 133.057 1.00 55.09  ? 696 ILE A CB    1 
ATOM   4520  C  CG1   . ILE A 1 704 ? 73.401  112.311 132.519 1.00 57.36  ? 696 ILE A CG1   1 
ATOM   4521  C  CG2   . ILE A 1 704 ? 74.126  110.687 134.279 1.00 56.81  ? 696 ILE A CG2   1 
ATOM   4522  C  CD1   . ILE A 1 704 ? 72.884  113.333 133.496 1.00 62.40  ? 696 ILE A CD1   1 
ATOM   4523  N  N     . VAL A 1 705 ? 77.411  111.467 134.929 1.00 52.66  ? 697 VAL A N     1 
ATOM   4524  C  CA    . VAL A 1 705 ? 78.532  110.643 135.358 1.00 54.09  ? 697 VAL A CA    1 
ATOM   4525  C  C     . VAL A 1 705 ? 77.979  109.383 136.005 1.00 58.14  ? 697 VAL A C     1 
ATOM   4526  O  O     . VAL A 1 705 ? 77.128  109.455 136.904 1.00 63.47  ? 697 VAL A O     1 
ATOM   4527  C  CB    . VAL A 1 705 ? 79.448  111.406 136.328 1.00 55.14  ? 697 VAL A CB    1 
ATOM   4528  C  CG1   . VAL A 1 705 ? 80.623  110.537 136.736 1.00 57.32  ? 697 VAL A CG1   1 
ATOM   4529  C  CG2   . VAL A 1 705 ? 79.930  112.696 135.692 1.00 55.36  ? 697 VAL A CG2   1 
ATOM   4530  N  N     . LEU A 1 706 ? 78.447  108.228 135.530 1.00 57.06  ? 698 LEU A N     1 
ATOM   4531  C  CA    . LEU A 1 706 ? 78.051  106.934 136.062 1.00 63.47  ? 698 LEU A CA    1 
ATOM   4532  C  C     . LEU A 1 706 ? 78.914  106.579 137.272 1.00 70.39  ? 698 LEU A C     1 
ATOM   4533  O  O     . LEU A 1 706 ? 80.108  106.888 137.296 1.00 71.43  ? 698 LEU A O     1 
ATOM   4534  C  CB    . LEU A 1 706 ? 78.184  105.852 134.993 1.00 62.67  ? 698 LEU A CB    1 
ATOM   4535  C  CG    . LEU A 1 706 ? 77.429  106.097 133.684 1.00 61.11  ? 698 LEU A CG    1 
ATOM   4536  C  CD1   . LEU A 1 706 ? 77.668  104.961 132.707 1.00 60.13  ? 698 LEU A CD1   1 
ATOM   4537  C  CD2   . LEU A 1 706 ? 75.943  106.275 133.944 1.00 66.68  ? 698 LEU A CD2   1 
ATOM   4538  N  N     . PRO A 1 707 ? 78.338  105.935 138.287 1.00 70.02  ? 699 PRO A N     1 
ATOM   4539  C  CA    . PRO A 1 707 ? 79.103  105.654 139.509 1.00 66.83  ? 699 PRO A CA    1 
ATOM   4540  C  C     . PRO A 1 707 ? 80.129  104.542 139.353 1.00 65.67  ? 699 PRO A C     1 
ATOM   4541  O  O     . PRO A 1 707 ? 81.264  104.674 139.821 1.00 68.08  ? 699 PRO A O     1 
ATOM   4542  C  CB    . PRO A 1 707 ? 78.012  105.266 140.513 1.00 68.76  ? 699 PRO A CB    1 
ATOM   4543  C  CG    . PRO A 1 707 ? 76.921  104.702 139.671 1.00 69.76  ? 699 PRO A CG    1 
ATOM   4544  C  CD    . PRO A 1 707 ? 76.940  105.483 138.387 1.00 67.56  ? 699 PRO A CD    1 
ATOM   4545  N  N     . ASN A 1 708 ? 79.750  103.447 138.691 1.00 62.72  ? 700 ASN A N     1 
ATOM   4546  C  CA    . ASN A 1 708 ? 80.558  102.233 138.651 1.00 64.08  ? 700 ASN A CA    1 
ATOM   4547  C  C     . ASN A 1 708 ? 81.262  102.033 137.313 1.00 63.78  ? 700 ASN A C     1 
ATOM   4548  O  O     . ASN A 1 708 ? 81.366  100.900 136.833 1.00 66.04  ? 700 ASN A O     1 
ATOM   4549  C  CB    . ASN A 1 708 ? 79.694  101.016 138.977 1.00 66.94  ? 700 ASN A CB    1 
ATOM   4550  C  CG    . ASN A 1 708 ? 79.148  101.051 140.388 1.00 73.35  ? 700 ASN A CG    1 
ATOM   4551  O  OD1   . ASN A 1 708 ? 79.767  101.613 141.291 1.00 71.10  ? 700 ASN A OD1   1 
ATOM   4552  N  ND2   . ASN A 1 708 ? 77.983  100.446 140.588 1.00 76.20  ? 700 ASN A ND2   1 
ATOM   4553  N  N     . ALA A 1 709 ? 81.746  103.108 136.698 1.00 64.41  ? 701 ALA A N     1 
ATOM   4554  C  CA    . ALA A 1 709 ? 82.481  103.023 135.446 1.00 59.29  ? 701 ALA A CA    1 
ATOM   4555  C  C     . ALA A 1 709 ? 83.763  103.832 135.556 1.00 56.44  ? 701 ALA A C     1 
ATOM   4556  O  O     . ALA A 1 709 ? 83.803  104.867 136.225 1.00 58.71  ? 701 ALA A O     1 
ATOM   4557  C  CB    . ALA A 1 709 ? 81.644  103.527 134.265 1.00 57.70  ? 701 ALA A CB    1 
ATOM   4558  N  N     . TYR A 1 710 ? 84.816  103.346 134.903 1.00 54.97  ? 702 TYR A N     1 
ATOM   4559  C  CA    . TYR A 1 710 ? 86.091  104.050 134.906 1.00 56.28  ? 702 TYR A CA    1 
ATOM   4560  C  C     . TYR A 1 710 ? 86.945  103.551 133.751 1.00 53.01  ? 702 TYR A C     1 
ATOM   4561  O  O     . TYR A 1 710 ? 86.714  102.473 133.199 1.00 48.09  ? 702 TYR A O     1 
ATOM   4562  C  CB    . TYR A 1 710 ? 86.831  103.876 136.238 1.00 53.16  ? 702 TYR A CB    1 
ATOM   4563  C  CG    . TYR A 1 710 ? 87.059  102.437 136.637 1.00 52.21  ? 702 TYR A CG    1 
ATOM   4564  C  CD1   . TYR A 1 710 ? 86.084  101.724 137.319 1.00 53.96  ? 702 TYR A CD1   1 
ATOM   4565  C  CD2   . TYR A 1 710 ? 88.252  101.795 136.341 1.00 52.91  ? 702 TYR A CD2   1 
ATOM   4566  C  CE1   . TYR A 1 710 ? 86.286  100.412 137.686 1.00 55.80  ? 702 TYR A CE1   1 
ATOM   4567  C  CE2   . TYR A 1 710 ? 88.464  100.482 136.705 1.00 56.90  ? 702 TYR A CE2   1 
ATOM   4568  C  CZ    . TYR A 1 710 ? 87.477  99.796  137.378 1.00 59.20  ? 702 TYR A CZ    1 
ATOM   4569  O  OH    . TYR A 1 710 ? 87.681  98.487  137.744 1.00 65.09  ? 702 TYR A OH    1 
ATOM   4570  N  N     . MET A 1 711 ? 87.940  104.361 133.397 1.00 53.69  ? 703 MET A N     1 
ATOM   4571  C  CA    . MET A 1 711 ? 88.900  104.021 132.359 1.00 48.71  ? 703 MET A CA    1 
ATOM   4572  C  C     . MET A 1 711 ? 90.237  104.645 132.725 1.00 52.43  ? 703 MET A C     1 
ATOM   4573  O  O     . MET A 1 711 ? 90.289  105.733 133.303 1.00 58.18  ? 703 MET A O     1 
ATOM   4574  C  CB    . MET A 1 711 ? 88.431  104.502 130.982 1.00 48.96  ? 703 MET A CB    1 
ATOM   4575  C  CG    . MET A 1 711 ? 88.303  106.010 130.859 1.00 52.38  ? 703 MET A CG    1 
ATOM   4576  S  SD    . MET A 1 711 ? 87.255  106.502 129.480 1.00 67.45  ? 703 MET A SD    1 
ATOM   4577  C  CE    . MET A 1 711 ? 87.786  105.335 128.235 1.00 54.56  ? 703 MET A CE    1 
ATOM   4578  N  N     . ILE A 1 712 ? 91.320  103.948 132.390 1.00 47.88  ? 704 ILE A N     1 
ATOM   4579  C  CA    . ILE A 1 712 ? 92.660  104.336 132.814 1.00 48.13  ? 704 ILE A CA    1 
ATOM   4580  C  C     . ILE A 1 712 ? 93.492  104.669 131.585 1.00 46.58  ? 704 ILE A C     1 
ATOM   4581  O  O     . ILE A 1 712 ? 93.590  103.858 130.658 1.00 49.93  ? 704 ILE A O     1 
ATOM   4582  C  CB    . ILE A 1 712 ? 93.331  103.229 133.647 1.00 47.14  ? 704 ILE A CB    1 
ATOM   4583  C  CG1   . ILE A 1 712 ? 92.432  102.839 134.821 1.00 46.43  ? 704 ILE A CG1   1 
ATOM   4584  C  CG2   . ILE A 1 712 ? 94.689  103.691 134.145 1.00 50.82  ? 704 ILE A CG2   1 
ATOM   4585  C  CD1   . ILE A 1 712 ? 93.021  101.782 135.718 1.00 54.12  ? 704 ILE A CD1   1 
ATOM   4586  N  N     . HIS A 1 713 ? 94.097  105.855 131.583 1.00 46.46  ? 705 HIS A N     1 
ATOM   4587  C  CA    . HIS A 1 713 ? 94.912  106.320 130.462 1.00 45.46  ? 705 HIS A CA    1 
ATOM   4588  C  C     . HIS A 1 713 ? 96.324  105.776 130.628 1.00 53.89  ? 705 HIS A C     1 
ATOM   4589  O  O     . HIS A 1 713 ? 97.109  106.288 131.430 1.00 60.37  ? 705 HIS A O     1 
ATOM   4590  C  CB    . HIS A 1 713 ? 94.911  107.842 130.392 1.00 48.10  ? 705 HIS A CB    1 
ATOM   4591  C  CG    . HIS A 1 713 ? 95.898  108.404 129.417 1.00 51.11  ? 705 HIS A CG    1 
ATOM   4592  N  ND1   . HIS A 1 713 ? 97.180  108.759 129.777 1.00 58.44  ? 705 HIS A ND1   1 
ATOM   4593  C  CD2   . HIS A 1 713 ? 95.790  108.679 128.096 1.00 52.22  ? 705 HIS A CD2   1 
ATOM   4594  C  CE1   . HIS A 1 713 ? 97.819  109.226 128.719 1.00 55.79  ? 705 HIS A CE1   1 
ATOM   4595  N  NE2   . HIS A 1 713 ? 96.998  109.187 127.686 1.00 53.73  ? 705 HIS A NE2   1 
ATOM   4596  N  N     . MET A 1 714 ? 96.651  104.738 129.867 1.00 55.44  ? 706 MET A N     1 
ATOM   4597  C  CA    . MET A 1 714 ? 97.990  104.175 129.923 1.00 58.92  ? 706 MET A CA    1 
ATOM   4598  C  C     . MET A 1 714 ? 98.997  105.160 129.334 1.00 62.55  ? 706 MET A C     1 
ATOM   4599  O  O     . MET A 1 714 ? 98.730  105.778 128.299 1.00 62.27  ? 706 MET A O     1 
ATOM   4600  C  CB    . MET A 1 714 ? 98.047  102.851 129.167 1.00 55.11  ? 706 MET A CB    1 
ATOM   4601  C  CG    . MET A 1 714 ? 96.967  101.868 129.577 1.00 52.86  ? 706 MET A CG    1 
ATOM   4602  S  SD    . MET A 1 714 ? 96.895  101.613 131.359 1.00 57.38  ? 706 MET A SD    1 
ATOM   4603  C  CE    . MET A 1 714 ? 98.532  100.962 131.678 1.00 67.10  ? 706 MET A CE    1 
ATOM   4604  N  N     . PRO A 1 715 ? 100.155 105.330 129.966 1.00 62.18  ? 707 PRO A N     1 
ATOM   4605  C  CA    . PRO A 1 715 ? 101.119 106.323 129.483 1.00 62.21  ? 707 PRO A CA    1 
ATOM   4606  C  C     . PRO A 1 715 ? 101.679 105.946 128.122 1.00 65.39  ? 707 PRO A C     1 
ATOM   4607  O  O     . PRO A 1 715 ? 101.784 104.769 127.768 1.00 67.53  ? 707 PRO A O     1 
ATOM   4608  C  CB    . PRO A 1 715 ? 102.211 106.307 130.557 1.00 68.35  ? 707 PRO A CB    1 
ATOM   4609  C  CG    . PRO A 1 715 ? 102.133 104.938 131.134 1.00 72.44  ? 707 PRO A CG    1 
ATOM   4610  C  CD    . PRO A 1 715 ? 100.679 104.558 131.105 1.00 62.85  ? 707 PRO A CD    1 
ATOM   4611  N  N     . HIS A 1 716 ? 102.036 106.971 127.354 1.00 62.02  ? 708 HIS A N     1 
ATOM   4612  C  CA    . HIS A 1 716 ? 102.578 106.781 126.019 1.00 63.57  ? 708 HIS A CA    1 
ATOM   4613  C  C     . HIS A 1 716 ? 103.605 107.851 125.690 1.00 65.69  ? 708 HIS A C     1 
ATOM   4614  O  O     . HIS A 1 716 ? 103.453 109.017 126.064 1.00 62.43  ? 708 HIS A O     1 
ATOM   4615  C  CB    . HIS A 1 716 ? 101.484 106.877 124.946 1.00 65.04  ? 708 HIS A CB    1 
ATOM   4616  C  CG    . HIS A 1 716 ? 100.891 108.245 124.806 1.00 60.66  ? 708 HIS A CG    1 
ATOM   4617  N  ND1   . HIS A 1 716 ? 101.568 109.293 124.223 1.00 62.23  ? 708 HIS A ND1   1 
ATOM   4618  C  CD2   . HIS A 1 716 ? 99.686  108.735 125.179 1.00 57.94  ? 708 HIS A CD2   1 
ATOM   4619  C  CE1   . HIS A 1 716 ? 100.805 110.372 124.241 1.00 63.54  ? 708 HIS A CE1   1 
ATOM   4620  N  NE2   . HIS A 1 716 ? 99.657  110.060 124.816 1.00 60.03  ? 708 HIS A NE2   1 
ATOM   4621  N  N     . ALA A 1 717 ? 104.652 107.441 124.984 1.00 73.14  ? 709 ALA A N     1 
ATOM   4622  C  CA    . ALA A 1 717 ? 105.643 108.394 124.516 1.00 77.88  ? 709 ALA A CA    1 
ATOM   4623  C  C     . ALA A 1 717 ? 105.011 109.498 123.673 1.00 77.35  ? 709 ALA A C     1 
ATOM   4624  O  O     . ALA A 1 717 ? 104.087 109.233 122.898 1.00 72.93  ? 709 ALA A O     1 
ATOM   4625  C  CB    . ALA A 1 717 ? 106.740 107.689 123.721 1.00 81.46  ? 709 ALA A CB    1 
ATOM   4626  N  N     . PRO A 1 718 ? 105.470 110.740 123.813 1.00 82.25  ? 710 PRO A N     1 
ATOM   4627  C  CA    . PRO A 1 718 ? 104.877 111.833 123.032 1.00 84.85  ? 710 PRO A CA    1 
ATOM   4628  C  C     . PRO A 1 718 ? 104.995 111.566 121.539 1.00 90.28  ? 710 PRO A C     1 
ATOM   4629  O  O     . PRO A 1 718 ? 106.048 111.163 121.042 1.00 92.59  ? 710 PRO A O     1 
ATOM   4630  C  CB    . PRO A 1 718 ? 105.696 113.057 123.457 1.00 85.03  ? 710 PRO A CB    1 
ATOM   4631  C  CG    . PRO A 1 718 ? 106.246 112.698 124.794 1.00 87.10  ? 710 PRO A CG    1 
ATOM   4632  C  CD    . PRO A 1 718 ? 106.508 111.222 124.737 1.00 83.56  ? 710 PRO A CD    1 
ATOM   4633  N  N     . SER A 1 719 ? 103.897 111.793 120.827 1.00 92.79  ? 711 SER A N     1 
ATOM   4634  C  CA    . SER A 1 719 ? 103.886 111.597 119.388 1.00 92.95  ? 711 SER A CA    1 
ATOM   4635  C  C     . SER A 1 719 ? 104.664 112.710 118.697 1.00 94.60  ? 711 SER A C     1 
ATOM   4636  O  O     . SER A 1 719 ? 104.974 113.749 119.288 1.00 96.86  ? 711 SER A O     1 
ATOM   4637  C  CB    . SER A 1 719 ? 102.453 111.554 118.866 1.00 84.60  ? 711 SER A CB    1 
ATOM   4638  O  OG    . SER A 1 719 ? 101.759 112.743 119.200 1.00 82.46  ? 711 SER A OG    1 
ATOM   4639  N  N     . PHE A 1 720 ? 104.988 112.478 117.422 1.00 90.51  ? 712 PHE A N     1 
ATOM   4640  C  CA    . PHE A 1 720 ? 105.678 113.506 116.652 1.00 90.87  ? 712 PHE A CA    1 
ATOM   4641  C  C     . PHE A 1 720 ? 104.842 114.772 116.552 1.00 90.69  ? 712 PHE A C     1 
ATOM   4642  O  O     . PHE A 1 720 ? 105.394 115.873 116.449 1.00 92.61  ? 712 PHE A O     1 
ATOM   4643  C  CB    . PHE A 1 720 ? 106.028 112.988 115.258 1.00 89.63  ? 712 PHE A CB    1 
ATOM   4644  C  CG    . PHE A 1 720 ? 106.681 114.016 114.380 1.00 88.10  ? 712 PHE A CG    1 
ATOM   4645  C  CD1   . PHE A 1 720 ? 108.017 114.337 114.545 1.00 86.42  ? 712 PHE A CD1   1 
ATOM   4646  C  CD2   . PHE A 1 720 ? 105.959 114.665 113.394 1.00 87.47  ? 712 PHE A CD2   1 
ATOM   4647  C  CE1   . PHE A 1 720 ? 108.620 115.284 113.743 1.00 84.16  ? 712 PHE A CE1   1 
ATOM   4648  C  CE2   . PHE A 1 720 ? 106.557 115.613 112.588 1.00 87.57  ? 712 PHE A CE2   1 
ATOM   4649  C  CZ    . PHE A 1 720 ? 107.889 115.922 112.763 1.00 87.25  ? 712 PHE A CZ    1 
ATOM   4650  N  N     . ASP A 1 721 ? 103.515 114.638 116.590 1.00 92.54  ? 713 ASP A N     1 
ATOM   4651  C  CA    . ASP A 1 721 ? 102.654 115.814 116.595 1.00 95.12  ? 713 ASP A CA    1 
ATOM   4652  C  C     . ASP A 1 721 ? 102.933 116.683 117.813 1.00 97.22  ? 713 ASP A C     1 
ATOM   4653  O  O     . ASP A 1 721 ? 103.206 117.880 117.686 1.00 99.85  ? 713 ASP A O     1 
ATOM   4654  C  CB    . ASP A 1 721 ? 101.187 115.387 116.562 1.00 93.12  ? 713 ASP A CB    1 
ATOM   4655  C  CG    . ASP A 1 721 ? 100.869 114.495 115.381 1.00 90.23  ? 713 ASP A CG    1 
ATOM   4656  O  OD1   . ASP A 1 721 ? 101.254 114.848 114.248 1.00 90.58  ? 713 ASP A OD1   1 
ATOM   4657  O  OD2   . ASP A 1 721 ? 100.240 113.437 115.588 1.00 88.23  ? 713 ASP A OD2   1 
ATOM   4658  N  N     . ILE A 1 722 ? 102.895 116.087 119.007 1.00 95.95  ? 714 ILE A N     1 
ATOM   4659  C  CA    . ILE A 1 722 ? 103.170 116.850 120.219 1.00 99.23  ? 714 ILE A CA    1 
ATOM   4660  C  C     . ILE A 1 722 ? 104.601 117.362 120.109 1.00 101.10 ? 714 ILE A C     1 
ATOM   4661  O  O     . ILE A 1 722 ? 104.844 118.574 120.151 1.00 101.40 ? 714 ILE A O     1 
ATOM   4662  C  CB    . ILE A 1 722 ? 102.866 116.001 121.466 1.00 101.11 ? 714 ILE A CB    1 
ATOM   4663  C  CG1   . ILE A 1 722 ? 101.468 115.389 121.366 1.00 101.61 ? 714 ILE A CG1   1 
ATOM   4664  C  CG2   . ILE A 1 722 ? 102.989 116.845 122.724 1.00 100.22 ? 714 ILE A CG2   1 
ATOM   4665  C  CD1   . ILE A 1 722 ? 101.100 114.517 122.546 1.00 97.67  ? 714 ILE A CD1   1 
ATOM   4666  N  N     . THR A 1 723 ? 105.561 116.450 119.933 1.00 99.77  ? 715 THR A N     1 
ATOM   4667  C  CA    . THR A 1 723 ? 106.968 116.836 119.901 1.00 99.08  ? 715 THR A CA    1 
ATOM   4668  C  C     . THR A 1 723 ? 107.269 118.044 119.024 1.00 100.61 ? 715 THR A C     1 
ATOM   4669  O  O     . THR A 1 723 ? 107.926 118.995 119.461 1.00 103.01 ? 715 THR A O     1 
ATOM   4670  C  CB    . THR A 1 723 ? 107.821 115.642 119.472 1.00 96.27  ? 715 THR A CB    1 
ATOM   4671  O  OG1   . THR A 1 723 ? 107.616 114.554 120.382 1.00 96.26  ? 715 THR A OG1   1 
ATOM   4672  C  CG2   . THR A 1 723 ? 109.292 116.020 119.455 1.00 95.20  ? 715 THR A CG2   1 
ATOM   4673  N  N     . LYS A 1 724 ? 106.788 118.030 117.781 1.00 100.21 ? 716 LYS A N     1 
ATOM   4674  C  CA    . LYS A 1 724 ? 107.040 119.151 116.884 1.00 100.68 ? 716 LYS A CA    1 
ATOM   4675  C  C     . LYS A 1 724 ? 106.154 120.339 117.235 1.00 102.62 ? 716 LYS A C     1 
ATOM   4676  O  O     . LYS A 1 724 ? 106.645 121.401 117.635 1.00 104.37 ? 716 LYS A O     1 
ATOM   4677  C  CB    . LYS A 1 724 ? 106.816 118.719 115.433 1.00 97.70  ? 716 LYS A CB    1 
ATOM   4678  C  CG    . LYS A 1 724 ? 106.825 119.860 114.429 1.00 98.19  ? 716 LYS A CG    1 
ATOM   4679  C  CD    . LYS A 1 724 ? 108.157 120.588 114.407 1.00 99.69  ? 716 LYS A CD    1 
ATOM   4680  C  CE    . LYS A 1 724 ? 108.150 121.705 113.378 1.00 99.91  ? 716 LYS A CE    1 
ATOM   4681  N  NZ    . LYS A 1 724 ? 107.826 121.198 112.017 1.00 97.48  ? 716 LYS A NZ    1 
ATOM   4682  N  N     . PHE A 1 725 ? 104.841 120.176 117.096 1.00 105.41 ? 717 PHE A N     1 
ATOM   4683  C  CA    . PHE A 1 725 ? 103.894 121.249 117.366 1.00 109.69 ? 717 PHE A CA    1 
ATOM   4684  C  C     . PHE A 1 725 ? 103.323 121.073 118.773 1.00 110.45 ? 717 PHE A C     1 
ATOM   4685  O  O     . PHE A 1 725 ? 102.140 120.798 118.977 1.00 112.15 ? 717 PHE A O     1 
ATOM   4686  C  CB    . PHE A 1 725 ? 102.799 121.255 116.305 1.00 106.88 ? 717 PHE A CB    1 
ATOM   4687  C  CG    . PHE A 1 725 ? 103.309 121.457 114.907 1.00 105.85 ? 717 PHE A CG    1 
ATOM   4688  C  CD1   . PHE A 1 725 ? 103.719 122.708 114.476 1.00 106.46 ? 717 PHE A CD1   1 
ATOM   4689  C  CD2   . PHE A 1 725 ? 103.370 120.396 114.020 1.00 108.50 ? 717 PHE A CD2   1 
ATOM   4690  C  CE1   . PHE A 1 725 ? 104.187 122.894 113.189 1.00 106.67 ? 717 PHE A CE1   1 
ATOM   4691  C  CE2   . PHE A 1 725 ? 103.838 120.576 112.732 1.00 109.04 ? 717 PHE A CE2   1 
ATOM   4692  C  CZ    . PHE A 1 725 ? 104.245 121.827 112.316 1.00 107.01 ? 717 PHE A CZ    1 
ATOM   4693  N  N     . ARG A 1 726 ? 104.205 121.235 119.758 1.00 106.93 ? 718 ARG A N     1 
ATOM   4694  C  CA    . ARG A 1 726 ? 103.836 121.047 121.155 1.00 109.84 ? 718 ARG A CA    1 
ATOM   4695  C  C     . ARG A 1 726 ? 103.107 122.260 121.721 1.00 118.06 ? 718 ARG A C     1 
ATOM   4696  O  O     . ARG A 1 726 ? 103.437 122.733 122.814 1.00 123.53 ? 718 ARG A O     1 
ATOM   4697  C  CB    . ARG A 1 726 ? 105.091 120.752 121.979 1.00 107.23 ? 718 ARG A CB    1 
ATOM   4698  C  CG    . ARG A 1 726 ? 106.199 121.776 121.779 1.00 108.94 ? 718 ARG A CG    1 
ATOM   4699  C  CD    . ARG A 1 726 ? 107.505 121.339 122.410 1.00 112.52 ? 718 ARG A CD    1 
ATOM   4700  N  NE    . ARG A 1 726 ? 108.505 122.399 122.346 1.00 116.86 ? 718 ARG A NE    1 
ATOM   4701  C  CZ    . ARG A 1 726 ? 109.240 122.676 121.278 1.00 116.07 ? 718 ARG A CZ    1 
ATOM   4702  N  NH1   . ARG A 1 726 ? 109.117 121.985 120.156 1.00 111.18 ? 718 ARG A NH1   1 
ATOM   4703  N  NH2   . ARG A 1 726 ? 110.119 123.672 121.335 1.00 118.77 ? 718 ARG A NH2   1 
ATOM   4704  N  N     . SER A 1 727 ? 102.091 122.739 121.001 1.00 112.78 ? 719 SER A N     1 
ATOM   4705  C  CA    . SER A 1 727 ? 101.302 123.899 121.418 1.00 116.95 ? 719 SER A CA    1 
ATOM   4706  C  C     . SER A 1 727 ? 102.203 125.074 121.789 1.00 120.83 ? 719 SER A C     1 
ATOM   4707  O  O     . SER A 1 727 ? 101.995 125.752 122.797 1.00 122.44 ? 719 SER A O     1 
ATOM   4708  C  CB    . SER A 1 727 ? 100.361 123.543 122.571 1.00 121.33 ? 719 SER A CB    1 
ATOM   4709  O  OG    . SER A 1 727 ? 101.083 123.202 123.741 1.00 123.53 ? 719 SER A OG    1 
ATOM   4710  N  N     . ASN A 1 728 ? 103.225 125.309 120.969 1.00 121.36 ? 720 ASN A N     1 
ATOM   4711  C  CA    . ASN A 1 728 ? 104.180 126.378 121.215 1.00 124.65 ? 720 ASN A CA    1 
ATOM   4712  C  C     . ASN A 1 728 ? 104.510 127.079 119.906 1.00 127.45 ? 720 ASN A C     1 
ATOM   4713  O  O     . ASN A 1 728 ? 104.559 126.453 118.843 1.00 125.50 ? 720 ASN A O     1 
ATOM   4714  C  CB    . ASN A 1 728 ? 105.466 125.845 121.865 1.00 119.98 ? 720 ASN A CB    1 
ATOM   4715  C  CG    . ASN A 1 728 ? 106.448 126.949 122.203 1.00 122.06 ? 720 ASN A CG    1 
ATOM   4716  O  OD1   . ASN A 1 728 ? 106.062 128.102 122.389 1.00 125.06 ? 720 ASN A OD1   1 
ATOM   4717  N  ND2   . ASN A 1 728 ? 107.727 126.601 122.278 1.00 121.41 ? 720 ASN A ND2   1 
ATOM   4718  N  N     . LYS A 1 729 ? 104.732 128.389 119.999 1.00 127.95 ? 721 LYS A N     1 
ATOM   4719  C  CA    . LYS A 1 729 ? 105.191 129.226 118.880 1.00 123.82 ? 721 LYS A CA    1 
ATOM   4720  C  C     . LYS A 1 729 ? 104.127 129.196 117.784 1.00 126.21 ? 721 LYS A C     1 
ATOM   4721  O  O     . LYS A 1 729 ? 102.959 129.516 118.067 1.00 123.07 ? 721 LYS A O     1 
ATOM   4722  C  CB    . LYS A 1 729 ? 106.582 128.771 118.455 1.00 118.55 ? 721 LYS A CB    1 
ATOM   4723  C  CG    . LYS A 1 729 ? 107.635 128.876 119.543 1.00 121.71 ? 721 LYS A CG    1 
ATOM   4724  C  CD    . LYS A 1 729 ? 108.972 128.335 119.065 1.00 124.93 ? 721 LYS A CD    1 
ATOM   4725  C  CE    . LYS A 1 729 ? 110.014 128.381 120.170 1.00 131.03 ? 721 LYS A CE    1 
ATOM   4726  N  NZ    . LYS A 1 729 ? 111.320 127.820 119.727 1.00 130.92 ? 721 LYS A NZ    1 
ATOM   4727  N  N     . GLN A 1 730 ? 104.476 128.834 116.546 1.00 129.32 ? 722 GLN A N     1 
ATOM   4728  C  CA    . GLN A 1 730 ? 103.541 128.948 115.432 1.00 127.79 ? 722 GLN A CA    1 
ATOM   4729  C  C     . GLN A 1 730 ? 102.309 128.080 115.644 1.00 126.94 ? 722 GLN A C     1 
ATOM   4730  O  O     . GLN A 1 730 ? 101.185 128.509 115.360 1.00 122.73 ? 722 GLN A O     1 
ATOM   4731  C  CB    . GLN A 1 730 ? 104.240 128.575 114.125 1.00 124.48 ? 722 GLN A CB    1 
ATOM   4732  C  CG    . GLN A 1 730 ? 103.330 128.576 112.908 1.00 126.40 ? 722 GLN A CG    1 
ATOM   4733  C  CD    . GLN A 1 730 ? 104.022 128.062 111.661 1.00 129.39 ? 722 GLN A CD    1 
ATOM   4734  O  OE1   . GLN A 1 730 ? 105.234 127.844 111.655 1.00 134.00 ? 722 GLN A OE1   1 
ATOM   4735  N  NE2   . GLN A 1 730 ? 103.253 127.860 110.597 1.00 123.12 ? 722 GLN A NE2   1 
ATOM   4736  N  N     . TYR A 1 731 ? 102.497 126.853 116.135 1.00 124.64 ? 723 TYR A N     1 
ATOM   4737  C  CA    . TYR A 1 731 ? 101.350 125.983 116.358 1.00 117.89 ? 723 TYR A CA    1 
ATOM   4738  C  C     . TYR A 1 731 ? 100.438 126.533 117.444 1.00 117.03 ? 723 TYR A C     1 
ATOM   4739  O  O     . TYR A 1 731 ? 99.214  126.435 117.336 1.00 113.31 ? 723 TYR A O     1 
ATOM   4740  C  CB    . TYR A 1 731 ? 101.799 124.573 116.720 1.00 110.70 ? 723 TYR A CB    1 
ATOM   4741  C  CG    . TYR A 1 731 ? 100.637 123.640 116.983 1.00 110.24 ? 723 TYR A CG    1 
ATOM   4742  C  CD1   . TYR A 1 731 ? 99.911  123.094 115.935 1.00 106.60 ? 723 TYR A CD1   1 
ATOM   4743  C  CD2   . TYR A 1 731 ? 100.269 123.304 118.276 1.00 113.50 ? 723 TYR A CD2   1 
ATOM   4744  C  CE1   . TYR A 1 731 ? 98.850  122.240 116.168 1.00 104.56 ? 723 TYR A CE1   1 
ATOM   4745  C  CE2   . TYR A 1 731 ? 99.210  122.451 118.521 1.00 111.50 ? 723 TYR A CE2   1 
ATOM   4746  C  CZ    . TYR A 1 731 ? 98.504  121.921 117.462 1.00 106.46 ? 723 TYR A CZ    1 
ATOM   4747  O  OH    . TYR A 1 731 ? 97.449  121.071 117.699 1.00 99.76  ? 723 TYR A OH    1 
ATOM   4748  N  N     . ARG A 1 732 ? 101.012 127.094 118.510 1.00 117.85 ? 724 ARG A N     1 
ATOM   4749  C  CA    . ARG A 1 732 ? 100.179 127.686 119.552 1.00 117.45 ? 724 ARG A CA    1 
ATOM   4750  C  C     . ARG A 1 732 ? 99.378  128.859 119.006 1.00 116.40 ? 724 ARG A C     1 
ATOM   4751  O  O     . ARG A 1 732 ? 98.182  128.993 119.297 1.00 116.35 ? 724 ARG A O     1 
ATOM   4752  C  CB    . ARG A 1 732 ? 101.038 128.126 120.737 1.00 123.26 ? 724 ARG A CB    1 
ATOM   4753  C  CG    . ARG A 1 732 ? 100.237 128.693 121.903 1.00 122.71 ? 724 ARG A CG    1 
ATOM   4754  C  CD    . ARG A 1 732 ? 101.073 128.769 123.172 1.00 120.66 ? 724 ARG A CD    1 
ATOM   4755  N  NE    . ARG A 1 732 ? 102.258 129.601 123.006 1.00 125.00 ? 724 ARG A NE    1 
ATOM   4756  C  CZ    . ARG A 1 732 ? 102.325 130.883 123.335 1.00 129.33 ? 724 ARG A CZ    1 
ATOM   4757  N  NH1   . ARG A 1 732 ? 101.287 131.517 123.856 1.00 129.40 ? 724 ARG A NH1   1 
ATOM   4758  N  NH2   . ARG A 1 732 ? 103.461 131.546 123.137 1.00 130.69 ? 724 ARG A NH2   1 
ATOM   4759  N  N     . ILE A 1 733 ? 100.014 129.708 118.195 1.00 116.03 ? 725 ILE A N     1 
ATOM   4760  C  CA    . ILE A 1 733 ? 99.303  130.840 117.607 1.00 117.04 ? 725 ILE A CA    1 
ATOM   4761  C  C     . ILE A 1 733 ? 98.177  130.352 116.704 1.00 115.43 ? 725 ILE A C     1 
ATOM   4762  O  O     . ILE A 1 733 ? 97.051  130.866 116.752 1.00 110.66 ? 725 ILE A O     1 
ATOM   4763  C  CB    . ILE A 1 733 ? 100.284 131.752 116.847 1.00 116.77 ? 725 ILE A CB    1 
ATOM   4764  C  CG1   . ILE A 1 733 ? 101.383 132.250 117.785 1.00 112.93 ? 725 ILE A CG1   1 
ATOM   4765  C  CG2   . ILE A 1 733 ? 99.545  132.925 116.224 1.00 114.43 ? 725 ILE A CG2   1 
ATOM   4766  C  CD1   . ILE A 1 733 ? 102.443 133.078 117.094 1.00 107.56 ? 725 ILE A CD1   1 
ATOM   4767  N  N     . CYS A 1 734 ? 98.459  129.347 115.872 1.00 112.65 ? 726 CYS A N     1 
ATOM   4768  C  CA    . CYS A 1 734 ? 97.449  128.842 114.948 1.00 111.89 ? 726 CYS A CA    1 
ATOM   4769  C  C     . CYS A 1 734 ? 96.304  128.160 115.687 1.00 109.70 ? 726 CYS A C     1 
ATOM   4770  O  O     . CYS A 1 734 ? 95.140  128.296 115.297 1.00 107.32 ? 726 CYS A O     1 
ATOM   4771  C  CB    . CYS A 1 734 ? 98.092  127.887 113.944 1.00 110.94 ? 726 CYS A CB    1 
ATOM   4772  S  SG    . CYS A 1 734 ? 99.298  128.677 112.853 1.00 119.52 ? 726 CYS A SG    1 
ATOM   4773  N  N     . LEU A 1 735 ? 96.612  127.418 116.752 1.00 109.57 ? 727 LEU A N     1 
ATOM   4774  C  CA    . LEU A 1 735 ? 95.564  126.775 117.537 1.00 104.25 ? 727 LEU A CA    1 
ATOM   4775  C  C     . LEU A 1 735 ? 94.702  127.806 118.250 1.00 102.23 ? 727 LEU A C     1 
ATOM   4776  O  O     . LEU A 1 735 ? 93.481  127.642 118.344 1.00 99.05  ? 727 LEU A O     1 
ATOM   4777  C  CB    . LEU A 1 735 ? 96.181  125.800 118.538 1.00 101.58 ? 727 LEU A CB    1 
ATOM   4778  C  CG    . LEU A 1 735 ? 95.189  124.998 119.378 1.00 96.91  ? 727 LEU A CG    1 
ATOM   4779  C  CD1   . LEU A 1 735 ? 94.222  124.251 118.477 1.00 88.67  ? 727 LEU A CD1   1 
ATOM   4780  C  CD2   . LEU A 1 735 ? 95.923  124.035 120.297 1.00 91.14  ? 727 LEU A CD2   1 
ATOM   4781  N  N     . LYS A 1 736 ? 95.316  128.877 118.758 1.00 102.65 ? 728 LYS A N     1 
ATOM   4782  C  CA    . LYS A 1 736 ? 94.533  129.957 119.348 1.00 104.15 ? 728 LYS A CA    1 
ATOM   4783  C  C     . LYS A 1 736 ? 93.630  130.607 118.308 1.00 106.43 ? 728 LYS A C     1 
ATOM   4784  O  O     . LYS A 1 736 ? 92.469  130.925 118.593 1.00 105.53 ? 728 LYS A O     1 
ATOM   4785  C  CB    . LYS A 1 736 ? 95.464  130.991 119.981 1.00 107.74 ? 728 LYS A CB    1 
ATOM   4786  C  CG    . LYS A 1 736 ? 94.745  132.123 120.693 1.00 109.63 ? 728 LYS A CG    1 
ATOM   4787  C  CD    . LYS A 1 736 ? 95.734  133.080 121.335 1.00 111.46 ? 728 LYS A CD    1 
ATOM   4788  C  CE    . LYS A 1 736 ? 95.020  134.197 122.078 1.00 114.87 ? 728 LYS A CE    1 
ATOM   4789  N  NZ    . LYS A 1 736 ? 95.982  135.130 122.727 1.00 118.56 ? 728 LYS A NZ    1 
ATOM   4790  N  N     . THR A 1 737 ? 94.146  130.810 117.092 1.00 104.84 ? 729 THR A N     1 
ATOM   4791  C  CA    . THR A 1 737 ? 93.327  131.382 116.027 1.00 104.13 ? 729 THR A CA    1 
ATOM   4792  C  C     . THR A 1 737 ? 92.156  130.469 115.677 1.00 101.16 ? 729 THR A C     1 
ATOM   4793  O  O     . THR A 1 737 ? 91.030  130.939 115.470 1.00 101.79 ? 729 THR A O     1 
ATOM   4794  C  CB    . THR A 1 737 ? 94.187  131.648 114.792 1.00 103.87 ? 729 THR A CB    1 
ATOM   4795  O  OG1   . THR A 1 737 ? 95.370  132.358 115.177 1.00 102.23 ? 729 THR A OG1   1 
ATOM   4796  C  CG2   . THR A 1 737 ? 93.416  132.478 113.778 1.00 104.97 ? 729 THR A CG2   1 
ATOM   4797  N  N     . LEU A 1 738 ? 92.405  129.159 115.603 1.00 95.07  ? 730 LEU A N     1 
ATOM   4798  C  CA    . LEU A 1 738 ? 91.330  128.211 115.321 1.00 93.92  ? 730 LEU A CA    1 
ATOM   4799  C  C     . LEU A 1 738 ? 90.295  128.203 116.439 1.00 95.86  ? 730 LEU A C     1 
ATOM   4800  O  O     . LEU A 1 738 ? 89.090  128.109 116.179 1.00 94.79  ? 730 LEU A O     1 
ATOM   4801  C  CB    . LEU A 1 738 ? 91.907  126.811 115.112 1.00 84.86  ? 730 LEU A CB    1 
ATOM   4802  C  CG    . LEU A 1 738 ? 92.794  126.605 113.884 1.00 82.60  ? 730 LEU A CG    1 
ATOM   4803  C  CD1   . LEU A 1 738 ? 93.435  125.228 113.910 1.00 77.69  ? 730 LEU A CD1   1 
ATOM   4804  C  CD2   . LEU A 1 738 ? 91.992  126.799 112.609 1.00 85.01  ? 730 LEU A CD2   1 
ATOM   4805  N  N     . LYS A 1 739 ? 90.748  128.293 117.691 1.00 94.44  ? 731 LYS A N     1 
ATOM   4806  C  CA    . LYS A 1 739 ? 89.823  128.383 118.816 1.00 91.63  ? 731 LYS A CA    1 
ATOM   4807  C  C     . LYS A 1 739 ? 88.962  129.636 118.722 1.00 92.70  ? 731 LYS A C     1 
ATOM   4808  O  O     . LYS A 1 739 ? 87.750  129.587 118.963 1.00 94.40  ? 731 LYS A O     1 
ATOM   4809  C  CB    . LYS A 1 739 ? 90.606  128.361 120.129 1.00 90.07  ? 731 LYS A CB    1 
ATOM   4810  C  CG    . LYS A 1 739 ? 89.841  128.874 121.336 1.00 91.35  ? 731 LYS A CG    1 
ATOM   4811  C  CD    . LYS A 1 739 ? 90.756  128.980 122.546 1.00 94.34  ? 731 LYS A CD    1 
ATOM   4812  C  CE    . LYS A 1 739 ? 90.064  129.667 123.712 1.00 100.97 ? 731 LYS A CE    1 
ATOM   4813  N  NZ    . LYS A 1 739 ? 90.943  129.749 124.911 1.00 104.40 ? 731 LYS A NZ    1 
ATOM   4814  N  N     . GLU A 1 740 ? 89.574  130.768 118.367 1.00 93.06  ? 732 GLU A N     1 
ATOM   4815  C  CA    . GLU A 1 740 ? 88.812  132.002 118.207 1.00 96.66  ? 732 GLU A CA    1 
ATOM   4816  C  C     . GLU A 1 740 ? 87.783  131.875 117.091 1.00 97.96  ? 732 GLU A C     1 
ATOM   4817  O  O     . GLU A 1 740 ? 86.639  132.322 117.235 1.00 98.86  ? 732 GLU A O     1 
ATOM   4818  C  CB    . GLU A 1 740 ? 89.759  133.169 117.933 1.00 101.45 ? 732 GLU A CB    1 
ATOM   4819  C  CG    . GLU A 1 740 ? 90.694  133.493 119.084 1.00 106.74 ? 732 GLU A CG    1 
ATOM   4820  C  CD    . GLU A 1 740 ? 91.788  134.465 118.690 1.00 109.84 ? 732 GLU A CD    1 
ATOM   4821  O  OE1   . GLU A 1 740 ? 91.826  134.871 117.509 1.00 108.83 ? 732 GLU A OE1   1 
ATOM   4822  O  OE2   . GLU A 1 740 ? 92.610  134.821 119.559 1.00 107.65 ? 732 GLU A OE2   1 
ATOM   4823  N  N     . GLU A 1 741 ? 88.174  131.270 115.966 1.00 98.47  ? 733 GLU A N     1 
ATOM   4824  C  CA    . GLU A 1 741 ? 87.236  131.084 114.863 1.00 98.66  ? 733 GLU A CA    1 
ATOM   4825  C  C     . GLU A 1 741 ? 86.081  130.175 115.268 1.00 96.07  ? 733 GLU A C     1 
ATOM   4826  O  O     . GLU A 1 741 ? 84.924  130.431 114.912 1.00 98.37  ? 733 GLU A O     1 
ATOM   4827  C  CB    . GLU A 1 741 ? 87.962  130.519 113.643 1.00 97.70  ? 733 GLU A CB    1 
ATOM   4828  C  CG    . GLU A 1 741 ? 88.978  131.469 113.029 1.00 99.22  ? 733 GLU A CG    1 
ATOM   4829  C  CD    . GLU A 1 741 ? 89.630  130.899 111.785 1.00 107.20 ? 733 GLU A CD    1 
ATOM   4830  O  OE1   . GLU A 1 741 ? 89.261  129.777 111.379 1.00 103.97 ? 733 GLU A OE1   1 
ATOM   4831  O  OE2   . GLU A 1 741 ? 90.511  131.574 111.212 1.00 111.32 ? 733 GLU A OE2   1 
ATOM   4832  N  N     . PHE A 1 742 ? 86.377  129.104 116.008 1.00 90.97  ? 734 PHE A N     1 
ATOM   4833  C  CA    . PHE A 1 742 ? 85.316  128.219 116.476 1.00 88.07  ? 734 PHE A CA    1 
ATOM   4834  C  C     . PHE A 1 742 ? 84.373  128.946 117.425 1.00 90.59  ? 734 PHE A C     1 
ATOM   4835  O  O     . PHE A 1 742 ? 83.156  128.746 117.372 1.00 90.20  ? 734 PHE A O     1 
ATOM   4836  C  CB    . PHE A 1 742 ? 85.908  126.985 117.154 1.00 80.71  ? 734 PHE A CB    1 
ATOM   4837  C  CG    . PHE A 1 742 ? 84.874  126.074 117.744 1.00 81.26  ? 734 PHE A CG    1 
ATOM   4838  C  CD1   . PHE A 1 742 ? 84.155  125.210 116.939 1.00 80.66  ? 734 PHE A CD1   1 
ATOM   4839  C  CD2   . PHE A 1 742 ? 84.611  126.090 119.103 1.00 80.72  ? 734 PHE A CD2   1 
ATOM   4840  C  CE1   . PHE A 1 742 ? 83.197  124.375 117.477 1.00 80.44  ? 734 PHE A CE1   1 
ATOM   4841  C  CE2   . PHE A 1 742 ? 83.655  125.257 119.647 1.00 77.19  ? 734 PHE A CE2   1 
ATOM   4842  C  CZ    . PHE A 1 742 ? 82.946  124.400 118.833 1.00 77.76  ? 734 PHE A CZ    1 
ATOM   4843  N  N     . GLN A 1 743 ? 84.918  129.783 118.310 1.00 94.44  ? 735 GLN A N     1 
ATOM   4844  C  CA    . GLN A 1 743 ? 84.068  130.559 119.208 1.00 93.71  ? 735 GLN A CA    1 
ATOM   4845  C  C     . GLN A 1 743 ? 83.178  131.521 118.432 1.00 94.87  ? 735 GLN A C     1 
ATOM   4846  O  O     . GLN A 1 743 ? 81.997  131.691 118.759 1.00 97.02  ? 735 GLN A O     1 
ATOM   4847  C  CB    . GLN A 1 743 ? 84.924  131.318 120.221 1.00 94.83  ? 735 GLN A CB    1 
ATOM   4848  C  CG    . GLN A 1 743 ? 85.604  130.432 121.250 1.00 99.02  ? 735 GLN A CG    1 
ATOM   4849  C  CD    . GLN A 1 743 ? 86.449  131.222 122.227 1.00 106.02 ? 735 GLN A CD    1 
ATOM   4850  O  OE1   . GLN A 1 743 ? 86.687  132.415 122.036 1.00 107.43 ? 735 GLN A OE1   1 
ATOM   4851  N  NE2   . GLN A 1 743 ? 86.907  130.562 123.283 1.00 107.14 ? 735 GLN A NE2   1 
ATOM   4852  N  N     . GLN A 1 744 ? 83.731  132.167 117.402 1.00 92.70  ? 736 GLN A N     1 
ATOM   4853  C  CA    . GLN A 1 744 ? 82.929  133.070 116.582 1.00 92.30  ? 736 GLN A CA    1 
ATOM   4854  C  C     . GLN A 1 744 ? 81.811  132.319 115.868 1.00 95.25  ? 736 GLN A C     1 
ATOM   4855  O  O     . GLN A 1 744 ? 80.674  132.802 115.797 1.00 100.05 ? 736 GLN A O     1 
ATOM   4856  C  CB    . GLN A 1 744 ? 83.819  133.797 115.576 1.00 94.59  ? 736 GLN A CB    1 
ATOM   4857  C  CG    . GLN A 1 744 ? 84.837  134.727 116.213 1.00 94.31  ? 736 GLN A CG    1 
ATOM   4858  C  CD    . GLN A 1 744 ? 85.751  135.377 115.194 1.00 101.41 ? 736 GLN A CD    1 
ATOM   4859  O  OE1   . GLN A 1 744 ? 85.485  135.343 113.993 1.00 106.16 ? 736 GLN A OE1   1 
ATOM   4860  N  NE2   . GLN A 1 744 ? 86.838  135.973 115.670 1.00 97.94  ? 736 GLN A NE2   1 
ATOM   4861  N  N     . ASP A 1 745 ? 82.115  131.136 115.330 1.00 92.40  ? 737 ASP A N     1 
ATOM   4862  C  CA    . ASP A 1 745 ? 81.081  130.338 114.677 1.00 93.88  ? 737 ASP A CA    1 
ATOM   4863  C  C     . ASP A 1 745 ? 80.022  129.880 115.674 1.00 94.31  ? 737 ASP A C     1 
ATOM   4864  O  O     . ASP A 1 745 ? 78.832  129.829 115.344 1.00 94.05  ? 737 ASP A O     1 
ATOM   4865  C  CB    . ASP A 1 745 ? 81.709  129.141 113.966 1.00 96.79  ? 737 ASP A CB    1 
ATOM   4866  C  CG    . ASP A 1 745 ? 82.554  129.552 112.776 1.00 98.57  ? 737 ASP A CG    1 
ATOM   4867  O  OD1   . ASP A 1 745 ? 82.318  130.650 112.229 1.00 98.90  ? 737 ASP A OD1   1 
ATOM   4868  O  OD2   . ASP A 1 745 ? 83.450  128.777 112.383 1.00 96.59  ? 737 ASP A OD2   1 
ATOM   4869  N  N     . MET A 1 746 ? 80.439  129.537 116.896 1.00 95.12  ? 738 MET A N     1 
ATOM   4870  C  CA    . MET A 1 746 ? 79.482  129.190 117.941 1.00 92.32  ? 738 MET A CA    1 
ATOM   4871  C  C     . MET A 1 746 ? 78.556  130.358 118.245 1.00 92.88  ? 738 MET A C     1 
ATOM   4872  O  O     . MET A 1 746 ? 77.340  130.180 118.384 1.00 94.73  ? 738 MET A O     1 
ATOM   4873  C  CB    . MET A 1 746 ? 80.223  128.762 119.207 1.00 90.36  ? 738 MET A CB    1 
ATOM   4874  C  CG    . MET A 1 746 ? 80.832  127.377 119.143 1.00 93.02  ? 738 MET A CG    1 
ATOM   4875  S  SD    . MET A 1 746 ? 79.591  126.087 119.333 1.00 102.93 ? 738 MET A SD    1 
ATOM   4876  C  CE    . MET A 1 746 ? 78.927  126.508 120.941 1.00 81.64  ? 738 MET A CE    1 
ATOM   4877  N  N     . SER A 1 747 ? 79.119  131.562 118.356 1.00 95.12  ? 739 SER A N     1 
ATOM   4878  C  CA    . SER A 1 747 ? 78.304  132.741 118.625 1.00 96.70  ? 739 SER A CA    1 
ATOM   4879  C  C     . SER A 1 747 ? 77.327  133.008 117.486 1.00 95.60  ? 739 SER A C     1 
ATOM   4880  O  O     . SER A 1 747 ? 76.161  133.341 117.724 1.00 96.66  ? 739 SER A O     1 
ATOM   4881  C  CB    . SER A 1 747 ? 79.201  133.956 118.857 1.00 95.62  ? 739 SER A CB    1 
ATOM   4882  O  OG    . SER A 1 747 ? 80.089  133.736 119.939 1.00 94.79  ? 739 SER A OG    1 
ATOM   4883  N  N     . ARG A 1 748 ? 77.787  132.869 116.242 1.00 92.72  ? 740 ARG A N     1 
ATOM   4884  C  CA    . ARG A 1 748 ? 76.932  133.185 115.102 1.00 93.10  ? 740 ARG A CA    1 
ATOM   4885  C  C     . ARG A 1 748 ? 75.823  132.154 114.920 1.00 93.49  ? 740 ARG A C     1 
ATOM   4886  O  O     . ARG A 1 748 ? 74.690  132.510 114.580 1.00 95.66  ? 740 ARG A O     1 
ATOM   4887  C  CB    . ARG A 1 748 ? 77.770  133.296 113.829 1.00 96.85  ? 740 ARG A CB    1 
ATOM   4888  C  CG    . ARG A 1 748 ? 78.733  134.470 113.819 1.00 103.76 ? 740 ARG A CG    1 
ATOM   4889  C  CD    . ARG A 1 748 ? 79.422  134.603 112.472 1.00 115.40 ? 740 ARG A CD    1 
ATOM   4890  N  NE    . ARG A 1 748 ? 80.325  135.747 112.431 1.00 130.13 ? 740 ARG A NE    1 
ATOM   4891  C  CZ    . ARG A 1 748 ? 80.974  136.150 111.348 1.00 137.30 ? 740 ARG A CZ    1 
ATOM   4892  N  NH1   . ARG A 1 748 ? 80.841  135.524 110.190 1.00 136.35 ? 740 ARG A NH1   1 
ATOM   4893  N  NH2   . ARG A 1 748 ? 81.776  137.208 111.428 1.00 143.28 ? 740 ARG A NH2   1 
ATOM   4894  N  N     . ARG A 1 749 ? 76.127  130.872 115.137 1.00 95.38  ? 741 ARG A N     1 
ATOM   4895  C  CA    . ARG A 1 749 ? 75.180  129.822 114.772 1.00 95.68  ? 741 ARG A CA    1 
ATOM   4896  C  C     . ARG A 1 749 ? 74.005  129.750 115.742 1.00 93.22  ? 741 ARG A C     1 
ATOM   4897  O  O     . ARG A 1 749 ? 72.859  129.560 115.319 1.00 90.15  ? 741 ARG A O     1 
ATOM   4898  C  CB    . ARG A 1 749 ? 75.898  128.475 114.697 1.00 94.46  ? 741 ARG A CB    1 
ATOM   4899  C  CG    . ARG A 1 749 ? 75.017  127.327 114.232 1.00 89.20  ? 741 ARG A CG    1 
ATOM   4900  C  CD    . ARG A 1 749 ? 75.815  126.042 114.089 1.00 90.45  ? 741 ARG A CD    1 
ATOM   4901  N  NE    . ARG A 1 749 ? 74.972  124.921 113.693 1.00 95.37  ? 741 ARG A NE    1 
ATOM   4902  C  CZ    . ARG A 1 749 ? 75.415  123.689 113.481 1.00 95.91  ? 741 ARG A CZ    1 
ATOM   4903  N  NH1   . ARG A 1 749 ? 76.695  123.382 113.614 1.00 94.14  ? 741 ARG A NH1   1 
ATOM   4904  N  NH2   . ARG A 1 749 ? 74.551  122.741 113.125 1.00 93.61  ? 741 ARG A NH2   1 
ATOM   4905  N  N     . TYR A 1 750 ? 74.263  129.891 117.043 1.00 93.50  ? 742 TYR A N     1 
ATOM   4906  C  CA    . TYR A 1 750 ? 73.227  129.714 118.050 1.00 91.19  ? 742 TYR A CA    1 
ATOM   4907  C  C     . TYR A 1 750 ? 72.825  131.001 118.754 1.00 95.51  ? 742 TYR A C     1 
ATOM   4908  O  O     . TYR A 1 750 ? 71.733  131.054 119.331 1.00 99.17  ? 742 TYR A O     1 
ATOM   4909  C  CB    . TYR A 1 750 ? 73.678  128.687 119.099 1.00 89.54  ? 742 TYR A CB    1 
ATOM   4910  C  CG    . TYR A 1 750 ? 74.126  127.373 118.505 1.00 84.22  ? 742 TYR A CG    1 
ATOM   4911  C  CD1   . TYR A 1 750 ? 73.212  126.371 118.216 1.00 82.34  ? 742 TYR A CD1   1 
ATOM   4912  C  CD2   . TYR A 1 750 ? 75.465  127.137 118.229 1.00 83.59  ? 742 TYR A CD2   1 
ATOM   4913  C  CE1   . TYR A 1 750 ? 73.619  125.170 117.671 1.00 82.95  ? 742 TYR A CE1   1 
ATOM   4914  C  CE2   . TYR A 1 750 ? 75.881  125.941 117.685 1.00 85.80  ? 742 TYR A CE2   1 
ATOM   4915  C  CZ    . TYR A 1 750 ? 74.955  124.961 117.407 1.00 85.31  ? 742 TYR A CZ    1 
ATOM   4916  O  OH    . TYR A 1 750 ? 75.368  123.767 116.865 1.00 86.36  ? 742 TYR A OH    1 
ATOM   4917  N  N     . GLY A 1 751 ? 73.667  132.030 118.732 1.00 97.54  ? 743 GLY A N     1 
ATOM   4918  C  CA    . GLY A 1 751 ? 73.307  133.311 119.308 1.00 100.30 ? 743 GLY A CA    1 
ATOM   4919  C  C     . GLY A 1 751 ? 73.293  133.350 120.823 1.00 102.24 ? 743 GLY A C     1 
ATOM   4920  O  O     . GLY A 1 751 ? 74.343  133.256 121.465 1.00 101.99 ? 743 GLY A O     1 
ATOM   4921  N  N     . PHE A 1 752 ? 72.099  133.499 121.403 1.00 101.61 ? 744 PHE A N     1 
ATOM   4922  C  CA    . PHE A 1 752 ? 71.986  133.678 122.847 1.00 102.45 ? 744 PHE A CA    1 
ATOM   4923  C  C     . PHE A 1 752 ? 72.409  132.432 123.615 1.00 103.09 ? 744 PHE A C     1 
ATOM   4924  O  O     . PHE A 1 752 ? 73.026  132.544 124.680 1.00 103.06 ? 744 PHE A O     1 
ATOM   4925  C  CB    . PHE A 1 752 ? 70.553  134.064 123.215 1.00 101.59 ? 744 PHE A CB    1 
ATOM   4926  C  CG    . PHE A 1 752 ? 70.379  134.452 124.655 1.00 107.01 ? 744 PHE A CG    1 
ATOM   4927  C  CD1   . PHE A 1 752 ? 70.644  135.746 125.073 1.00 110.50 ? 744 PHE A CD1   1 
ATOM   4928  C  CD2   . PHE A 1 752 ? 69.945  133.527 125.590 1.00 107.63 ? 744 PHE A CD2   1 
ATOM   4929  C  CE1   . PHE A 1 752 ? 70.485  136.108 126.397 1.00 111.67 ? 744 PHE A CE1   1 
ATOM   4930  C  CE2   . PHE A 1 752 ? 69.784  133.883 126.916 1.00 107.41 ? 744 PHE A CE2   1 
ATOM   4931  C  CZ    . PHE A 1 752 ? 70.054  135.176 127.319 1.00 108.76 ? 744 PHE A CZ    1 
ATOM   4932  N  N     . ALA A 1 753 ? 72.087  131.244 123.101 1.00 100.24 ? 745 ALA A N     1 
ATOM   4933  C  CA    . ALA A 1 753 ? 72.385  130.009 123.816 1.00 96.64  ? 745 ALA A CA    1 
ATOM   4934  C  C     . ALA A 1 753 ? 73.876  129.716 123.914 1.00 95.05  ? 745 ALA A C     1 
ATOM   4935  O  O     . ALA A 1 753 ? 74.263  128.843 124.699 1.00 90.03  ? 745 ALA A O     1 
ATOM   4936  C  CB    . ALA A 1 753 ? 71.675  128.832 123.145 1.00 93.67  ? 745 ALA A CB    1 
ATOM   4937  N  N     . ALA A 1 754 ? 74.717  130.413 123.150 1.00 96.87  ? 746 ALA A N     1 
ATOM   4938  C  CA    . ALA A 1 754 ? 76.151  130.155 123.126 1.00 95.90  ? 746 ALA A CA    1 
ATOM   4939  C  C     . ALA A 1 754 ? 76.966  131.308 123.701 1.00 96.75  ? 746 ALA A C     1 
ATOM   4940  O  O     . ALA A 1 754 ? 78.161  131.421 123.412 1.00 97.76  ? 746 ALA A O     1 
ATOM   4941  C  CB    . ALA A 1 754 ? 76.610  129.846 121.701 1.00 94.42  ? 746 ALA A CB    1 
ATOM   4942  N  N     . LEU A 1 755 ? 76.345  132.170 124.508 1.00 97.11  ? 747 LEU A N     1 
ATOM   4943  C  CA    . LEU A 1 755 ? 77.063  133.323 125.041 1.00 98.25  ? 747 LEU A CA    1 
ATOM   4944  C  C     . LEU A 1 755 ? 78.017  132.936 126.164 1.00 97.04  ? 747 LEU A C     1 
ATOM   4945  O  O     . LEU A 1 755 ? 79.055  133.583 126.341 1.00 98.39  ? 747 LEU A O     1 
ATOM   4946  C  CB    . LEU A 1 755 ? 76.071  134.378 125.530 1.00 99.65  ? 747 LEU A CB    1 
ATOM   4947  C  CG    . LEU A 1 755 ? 75.167  134.999 124.464 1.00 102.31 ? 747 LEU A CG    1 
ATOM   4948  C  CD1   . LEU A 1 755 ? 74.241  136.034 125.083 1.00 101.46 ? 747 LEU A CD1   1 
ATOM   4949  C  CD2   . LEU A 1 755 ? 75.997  135.616 123.349 1.00 102.31 ? 747 LEU A CD2   1 
ATOM   4950  N  N     . LYS A 1 756 ? 77.691  131.892 126.928 1.00 94.77  ? 748 LYS A N     1 
ATOM   4951  C  CA    . LYS A 1 756 ? 78.474  131.551 128.110 1.00 94.48  ? 748 LYS A CA    1 
ATOM   4952  C  C     . LYS A 1 756 ? 79.845  130.976 127.783 1.00 95.58  ? 748 LYS A C     1 
ATOM   4953  O  O     . LYS A 1 756 ? 80.667  130.836 128.695 1.00 96.24  ? 748 LYS A O     1 
ATOM   4954  C  CB    . LYS A 1 756 ? 77.699  130.564 128.985 1.00 91.66  ? 748 LYS A CB    1 
ATOM   4955  C  CG    . LYS A 1 756 ? 77.263  129.300 128.271 1.00 86.73  ? 748 LYS A CG    1 
ATOM   4956  C  CD    . LYS A 1 756 ? 76.419  128.432 129.188 1.00 88.10  ? 748 LYS A CD    1 
ATOM   4957  C  CE    . LYS A 1 756 ? 75.865  127.224 128.457 1.00 87.44  ? 748 LYS A CE    1 
ATOM   4958  N  NZ    . LYS A 1 756 ? 74.999  126.394 129.338 1.00 91.35  ? 748 LYS A NZ    1 
ATOM   4959  N  N     . TYR A 1 757 ? 80.115  130.640 126.524 1.00 98.39  ? 749 TYR A N     1 
ATOM   4960  C  CA    . TYR A 1 757 ? 81.403  130.078 126.141 1.00 97.74  ? 749 TYR A CA    1 
ATOM   4961  C  C     . TYR A 1 757 ? 82.444  131.137 125.808 1.00 103.81 ? 749 TYR A C     1 
ATOM   4962  O  O     . TYR A 1 757 ? 83.608  130.787 125.586 1.00 103.22 ? 749 TYR A O     1 
ATOM   4963  C  CB    . TYR A 1 757 ? 81.235  129.142 124.942 1.00 89.17  ? 749 TYR A CB    1 
ATOM   4964  C  CG    . TYR A 1 757 ? 80.127  128.135 125.115 1.00 84.02  ? 749 TYR A CG    1 
ATOM   4965  C  CD1   . TYR A 1 757 ? 80.321  126.985 125.862 1.00 80.17  ? 749 TYR A CD1   1 
ATOM   4966  C  CD2   . TYR A 1 757 ? 78.888  128.335 124.530 1.00 86.01  ? 749 TYR A CD2   1 
ATOM   4967  C  CE1   . TYR A 1 757 ? 79.310  126.062 126.023 1.00 80.05  ? 749 TYR A CE1   1 
ATOM   4968  C  CE2   . TYR A 1 757 ? 77.871  127.419 124.685 1.00 85.30  ? 749 TYR A CE2   1 
ATOM   4969  C  CZ    . TYR A 1 757 ? 78.087  126.284 125.432 1.00 82.74  ? 749 TYR A CZ    1 
ATOM   4970  O  OH    . TYR A 1 757 ? 77.073  125.368 125.587 1.00 82.50  ? 749 TYR A OH    1 
ATOM   4971  N  N     . LEU A 1 758 ? 82.057  132.413 125.761 1.00 106.47 ? 750 LEU A N     1 
ATOM   4972  C  CA    . LEU A 1 758 ? 83.013  133.465 125.429 1.00 108.27 ? 750 LEU A CA    1 
ATOM   4973  C  C     . LEU A 1 758 ? 84.091  133.595 126.499 1.00 111.21 ? 750 LEU A C     1 
ATOM   4974  O  O     . LEU A 1 758 ? 85.264  133.819 126.181 1.00 110.90 ? 750 LEU A O     1 
ATOM   4975  C  CB    . LEU A 1 758 ? 82.284  134.794 125.237 1.00 105.05 ? 750 LEU A CB    1 
ATOM   4976  C  CG    . LEU A 1 758 ? 81.218  134.825 124.141 1.00 104.66 ? 750 LEU A CG    1 
ATOM   4977  C  CD1   . LEU A 1 758 ? 80.619  136.217 124.014 1.00 104.42 ? 750 LEU A CD1   1 
ATOM   4978  C  CD2   . LEU A 1 758 ? 81.798  134.363 122.813 1.00 104.50 ? 750 LEU A CD2   1 
ATOM   4979  N  N     . THR A 1 759 ? 83.714  133.458 127.767 1.00 111.91 ? 751 THR A N     1 
ATOM   4980  C  CA    . THR A 1 759 ? 84.649  133.586 128.876 1.00 114.53 ? 751 THR A CA    1 
ATOM   4981  C  C     . THR A 1 759 ? 85.362  132.282 129.207 1.00 114.01 ? 751 THR A C     1 
ATOM   4982  O  O     . THR A 1 759 ? 86.165  132.253 130.145 1.00 110.97 ? 751 THR A O     1 
ATOM   4983  C  CB    . THR A 1 759 ? 83.923  134.102 130.124 1.00 113.72 ? 751 THR A CB    1 
ATOM   4984  O  OG1   . THR A 1 759 ? 82.873  133.194 130.478 1.00 110.35 ? 751 THR A OG1   1 
ATOM   4985  C  CG2   . THR A 1 759 ? 83.330  135.477 129.863 1.00 112.34 ? 751 THR A CG2   1 
ATOM   4986  N  N     . ALA A 1 760 ? 85.088  131.210 128.470 1.00 116.00 ? 752 ALA A N     1 
ATOM   4987  C  CA    . ALA A 1 760 ? 85.732  129.925 128.713 1.00 116.78 ? 752 ALA A CA    1 
ATOM   4988  C  C     . ALA A 1 760 ? 87.224  129.988 128.402 1.00 119.50 ? 752 ALA A C     1 
ATOM   4989  O  O     . ALA A 1 760 ? 87.678  130.839 127.636 1.00 122.97 ? 752 ALA A O     1 
ATOM   4990  C  CB    . ALA A 1 760 ? 85.066  128.835 127.889 1.00 108.21 ? 752 ALA A CB    1 
ATOM   4991  N  N     . LYS B 1 142 ? 117.728 102.814 70.613  1.00 99.27  ? 134 LYS B N     1 
ATOM   4992  C  CA    . LYS B 1 142 ? 116.727 102.492 71.623  1.00 104.27 ? 134 LYS B CA    1 
ATOM   4993  C  C     . LYS B 1 142 ? 117.320 102.557 73.025  1.00 107.84 ? 134 LYS B C     1 
ATOM   4994  O  O     . LYS B 1 142 ? 116.753 103.183 73.920  1.00 108.55 ? 134 LYS B O     1 
ATOM   4995  C  CB    . LYS B 1 142 ? 116.133 101.107 71.368  1.00 107.65 ? 134 LYS B CB    1 
ATOM   4996  C  CG    . LYS B 1 142 ? 115.109 100.675 72.403  1.00 110.00 ? 134 LYS B CG    1 
ATOM   4997  C  CD    . LYS B 1 142 ? 114.593 99.273  72.121  1.00 114.97 ? 134 LYS B CD    1 
ATOM   4998  C  CE    . LYS B 1 142 ? 113.578 98.838  73.165  1.00 117.34 ? 134 LYS B CE    1 
ATOM   4999  N  NZ    . LYS B 1 142 ? 113.076 97.460  72.911  1.00 120.26 ? 134 LYS B NZ    1 
ATOM   5000  N  N     . CYS B 1 143 ? 118.465 101.900 73.213  1.00 107.60 ? 135 CYS B N     1 
ATOM   5001  C  CA    . CYS B 1 143 ? 119.166 101.881 74.491  1.00 104.90 ? 135 CYS B CA    1 
ATOM   5002  C  C     . CYS B 1 143 ? 120.375 102.810 74.499  1.00 97.21  ? 135 CYS B C     1 
ATOM   5003  O  O     . CYS B 1 143 ? 121.387 102.505 75.139  1.00 95.60  ? 135 CYS B O     1 
ATOM   5004  C  CB    . CYS B 1 143 ? 119.592 100.456 74.843  1.00 109.44 ? 135 CYS B CB    1 
ATOM   5005  S  SG    . CYS B 1 143 ? 118.239 99.260  74.932  1.00 131.48 ? 135 CYS B SG    1 
ATOM   5006  N  N     . GLU B 1 144 ? 120.294 103.934 73.792  1.00 89.67  ? 136 GLU B N     1 
ATOM   5007  C  CA    . GLU B 1 144 ? 121.410 104.867 73.738  1.00 82.22  ? 136 GLU B CA    1 
ATOM   5008  C  C     . GLU B 1 144 ? 121.646 105.500 75.103  1.00 81.44  ? 136 GLU B C     1 
ATOM   5009  O  O     . GLU B 1 144 ? 120.706 105.919 75.784  1.00 82.65  ? 136 GLU B O     1 
ATOM   5010  C  CB    . GLU B 1 144 ? 121.144 105.950 72.694  1.00 82.58  ? 136 GLU B CB    1 
ATOM   5011  C  CG    . GLU B 1 144 ? 122.274 106.950 72.533  1.00 83.50  ? 136 GLU B CG    1 
ATOM   5012  C  CD    . GLU B 1 144 ? 121.990 107.982 71.462  1.00 87.31  ? 136 GLU B CD    1 
ATOM   5013  O  OE1   . GLU B 1 144 ? 120.949 107.864 70.782  1.00 88.66  ? 136 GLU B OE1   1 
ATOM   5014  O  OE2   . GLU B 1 144 ? 122.807 108.912 71.299  1.00 85.35  ? 136 GLU B OE2   1 
ATOM   5015  N  N     . THR B 1 145 ? 122.913 105.569 75.501  1.00 81.43  ? 137 THR B N     1 
ATOM   5016  C  CA    . THR B 1 145 ? 123.260 106.115 76.806  1.00 74.99  ? 137 THR B CA    1 
ATOM   5017  C  C     . THR B 1 145 ? 123.131 107.633 76.801  1.00 73.32  ? 137 THR B C     1 
ATOM   5018  O  O     . THR B 1 145 ? 123.669 108.311 75.921  1.00 71.62  ? 137 THR B O     1 
ATOM   5019  C  CB    . THR B 1 145 ? 124.681 105.706 77.190  1.00 74.19  ? 137 THR B CB    1 
ATOM   5020  O  OG1   . THR B 1 145 ? 124.726 104.293 77.424  1.00 83.24  ? 137 THR B OG1   1 
ATOM   5021  C  CG2   . THR B 1 145 ? 125.132 106.439 78.444  1.00 62.05  ? 137 THR B CG2   1 
ATOM   5022  N  N     . ILE B 1 146 ? 122.419 108.162 77.790  1.00 74.33  ? 138 ILE B N     1 
ATOM   5023  C  CA    . ILE B 1 146 ? 122.220 109.597 77.948  1.00 66.19  ? 138 ILE B CA    1 
ATOM   5024  C  C     . ILE B 1 146 ? 123.122 110.074 79.076  1.00 60.19  ? 138 ILE B C     1 
ATOM   5025  O  O     . ILE B 1 146 ? 123.063 109.547 80.193  1.00 57.85  ? 138 ILE B O     1 
ATOM   5026  C  CB    . ILE B 1 146 ? 120.748 109.929 78.236  1.00 64.27  ? 138 ILE B CB    1 
ATOM   5027  C  CG1   . ILE B 1 146 ? 119.864 109.452 77.083  1.00 63.63  ? 138 ILE B CG1   1 
ATOM   5028  C  CG2   . ILE B 1 146 ? 120.572 111.419 78.467  1.00 61.91  ? 138 ILE B CG2   1 
ATOM   5029  C  CD1   . ILE B 1 146 ? 118.391 109.632 77.334  1.00 68.32  ? 138 ILE B CD1   1 
ATOM   5030  N  N     . HIS B 1 147 ? 123.956 111.068 78.788  1.00 57.62  ? 139 HIS B N     1 
ATOM   5031  C  CA    . HIS B 1 147 ? 124.946 111.564 79.734  1.00 55.14  ? 139 HIS B CA    1 
ATOM   5032  C  C     . HIS B 1 147 ? 124.448 112.861 80.356  1.00 45.81  ? 139 HIS B C     1 
ATOM   5033  O  O     . HIS B 1 147 ? 124.130 113.816 79.641  1.00 47.02  ? 139 HIS B O     1 
ATOM   5034  C  CB    . HIS B 1 147 ? 126.291 111.779 79.042  1.00 58.08  ? 139 HIS B CB    1 
ATOM   5035  C  CG    . HIS B 1 147 ? 126.873 110.530 78.458  1.00 54.95  ? 139 HIS B CG    1 
ATOM   5036  N  ND1   . HIS B 1 147 ? 127.956 109.884 79.013  1.00 52.77  ? 139 HIS B ND1   1 
ATOM   5037  C  CD2   . HIS B 1 147 ? 126.518 109.804 77.372  1.00 58.53  ? 139 HIS B CD2   1 
ATOM   5038  C  CE1   . HIS B 1 147 ? 128.246 108.816 78.291  1.00 58.91  ? 139 HIS B CE1   1 
ATOM   5039  N  NE2   . HIS B 1 147 ? 127.388 108.745 77.290  1.00 60.12  ? 139 HIS B NE2   1 
ATOM   5040  N  N     . VAL B 1 148 ? 124.387 112.891 81.685  1.00 45.64  ? 140 VAL B N     1 
ATOM   5041  C  CA    . VAL B 1 148 ? 123.904 114.043 82.438  1.00 43.55  ? 140 VAL B CA    1 
ATOM   5042  C  C     . VAL B 1 148 ? 125.016 114.495 83.372  1.00 45.25  ? 140 VAL B C     1 
ATOM   5043  O  O     . VAL B 1 148 ? 125.511 113.704 84.181  1.00 46.94  ? 140 VAL B O     1 
ATOM   5044  C  CB    . VAL B 1 148 ? 122.632 113.714 83.234  1.00 42.09  ? 140 VAL B CB    1 
ATOM   5045  C  CG1   . VAL B 1 148 ? 122.057 114.975 83.847  1.00 43.64  ? 140 VAL B CG1   1 
ATOM   5046  C  CG2   . VAL B 1 148 ? 121.610 113.024 82.349  1.00 45.50  ? 140 VAL B CG2   1 
ATOM   5047  N  N     . ALA B 1 149 ? 125.391 115.765 83.275  1.00 43.12  ? 141 ALA B N     1 
ATOM   5048  C  CA    . ALA B 1 149 ? 126.451 116.348 84.087  1.00 39.20  ? 141 ALA B CA    1 
ATOM   5049  C  C     . ALA B 1 149 ? 125.832 117.260 85.136  1.00 40.59  ? 141 ALA B C     1 
ATOM   5050  O  O     . ALA B 1 149 ? 125.094 118.194 84.798  1.00 46.40  ? 141 ALA B O     1 
ATOM   5051  C  CB    . ALA B 1 149 ? 127.444 117.121 83.220  1.00 44.36  ? 141 ALA B CB    1 
ATOM   5052  N  N     . ILE B 1 150 ? 126.144 116.998 86.403  1.00 42.89  ? 142 ILE B N     1 
ATOM   5053  C  CA    . ILE B 1 150 ? 125.592 117.744 87.526  1.00 42.14  ? 142 ILE B CA    1 
ATOM   5054  C  C     . ILE B 1 150 ? 126.735 118.203 88.419  1.00 44.63  ? 142 ILE B C     1 
ATOM   5055  O  O     . ILE B 1 150 ? 127.653 117.430 88.712  1.00 47.19  ? 142 ILE B O     1 
ATOM   5056  C  CB    . ILE B 1 150 ? 124.582 116.901 88.334  1.00 39.58  ? 142 ILE B CB    1 
ATOM   5057  C  CG1   . ILE B 1 150 ? 123.600 116.195 87.399  1.00 41.82  ? 142 ILE B CG1   1 
ATOM   5058  C  CG2   . ILE B 1 150 ? 123.827 117.776 89.314  1.00 37.37  ? 142 ILE B CG2   1 
ATOM   5059  C  CD1   . ILE B 1 150 ? 122.650 115.265 88.105  1.00 44.32  ? 142 ILE B CD1   1 
ATOM   5060  N  N     . VAL B 1 151 ? 126.680 119.459 88.849  1.00 44.13  ? 143 VAL B N     1 
ATOM   5061  C  CA    . VAL B 1 151 ? 127.664 120.024 89.764  1.00 46.97  ? 143 VAL B CA    1 
ATOM   5062  C  C     . VAL B 1 151 ? 127.038 120.083 91.150  1.00 52.27  ? 143 VAL B C     1 
ATOM   5063  O  O     . VAL B 1 151 ? 125.994 120.719 91.341  1.00 57.59  ? 143 VAL B O     1 
ATOM   5064  C  CB    . VAL B 1 151 ? 128.124 121.416 89.305  1.00 49.82  ? 143 VAL B CB    1 
ATOM   5065  C  CG1   . VAL B 1 151 ? 129.131 121.991 90.286  1.00 52.90  ? 143 VAL B CG1   1 
ATOM   5066  C  CG2   . VAL B 1 151 ? 128.715 121.343 87.909  1.00 56.12  ? 143 VAL B CG2   1 
ATOM   5067  N  N     . CYS B 1 152 ? 127.670 119.422 92.118  1.00 53.75  ? 144 CYS B N     1 
ATOM   5068  C  CA    . CYS B 1 152 ? 127.139 119.324 93.471  1.00 54.60  ? 144 CYS B CA    1 
ATOM   5069  C  C     . CYS B 1 152 ? 128.211 119.711 94.478  1.00 61.46  ? 144 CYS B C     1 
ATOM   5070  O  O     . CYS B 1 152 ? 129.385 119.371 94.307  1.00 61.15  ? 144 CYS B O     1 
ATOM   5071  C  CB    . CYS B 1 152 ? 126.632 117.909 93.762  1.00 49.94  ? 144 CYS B CB    1 
ATOM   5072  S  SG    . CYS B 1 152 ? 125.954 117.687 95.417  1.00 71.10  ? 144 CYS B SG    1 
ATOM   5073  N  N     . ALA B 1 153 ? 127.805 120.425 95.528  1.00 60.39  ? 145 ALA B N     1 
ATOM   5074  C  CA    . ALA B 1 153 ? 128.747 120.852 96.562  1.00 60.47  ? 145 ALA B CA    1 
ATOM   5075  C  C     . ALA B 1 153 ? 127.969 121.161 97.834  1.00 63.72  ? 145 ALA B C     1 
ATOM   5076  O  O     . ALA B 1 153 ? 127.227 122.146 97.880  1.00 65.50  ? 145 ALA B O     1 
ATOM   5077  C  CB    . ALA B 1 153 ? 129.543 122.064 96.100  1.00 71.00  ? 145 ALA B CB    1 
ATOM   5078  N  N     . GLY B 1 154 ? 128.153 120.338 98.861  1.00 64.67  ? 146 GLY B N     1 
ATOM   5079  C  CA    . GLY B 1 154 ? 127.508 120.540 100.141 1.00 55.82  ? 146 GLY B CA    1 
ATOM   5080  C  C     . GLY B 1 154 ? 126.390 119.542 100.393 1.00 52.28  ? 146 GLY B C     1 
ATOM   5081  O  O     . GLY B 1 154 ? 125.977 118.773 99.522  1.00 53.31  ? 146 GLY B O     1 
ATOM   5082  N  N     . TYR B 1 155 ? 125.890 119.572 101.630 1.00 50.90  ? 147 TYR B N     1 
ATOM   5083  C  CA    . TYR B 1 155 ? 124.831 118.650 102.029 1.00 47.79  ? 147 TYR B CA    1 
ATOM   5084  C  C     . TYR B 1 155 ? 123.484 119.068 101.451 1.00 48.02  ? 147 TYR B C     1 
ATOM   5085  O  O     . TYR B 1 155 ? 122.686 118.217 101.035 1.00 47.77  ? 147 TYR B O     1 
ATOM   5086  C  CB    . TYR B 1 155 ? 124.770 118.570 103.553 1.00 42.66  ? 147 TYR B CB    1 
ATOM   5087  C  CG    . TYR B 1 155 ? 126.135 118.502 104.202 1.00 46.14  ? 147 TYR B CG    1 
ATOM   5088  C  CD1   . TYR B 1 155 ? 126.753 117.285 104.434 1.00 42.49  ? 147 TYR B CD1   1 
ATOM   5089  C  CD2   . TYR B 1 155 ? 126.807 119.658 104.575 1.00 48.96  ? 147 TYR B CD2   1 
ATOM   5090  C  CE1   . TYR B 1 155 ? 128.000 117.217 105.019 1.00 43.61  ? 147 TYR B CE1   1 
ATOM   5091  C  CE2   . TYR B 1 155 ? 128.054 119.600 105.161 1.00 51.67  ? 147 TYR B CE2   1 
ATOM   5092  C  CZ    . TYR B 1 155 ? 128.645 118.377 105.382 1.00 50.90  ? 147 TYR B CZ    1 
ATOM   5093  O  OH    . TYR B 1 155 ? 129.887 118.313 105.967 1.00 56.36  ? 147 TYR B OH    1 
ATOM   5094  N  N     . ASN B 1 156 ? 123.211 120.374 101.419 1.00 45.35  ? 148 ASN B N     1 
ATOM   5095  C  CA    . ASN B 1 156 ? 121.995 120.852 100.771 1.00 47.30  ? 148 ASN B CA    1 
ATOM   5096  C  C     . ASN B 1 156 ? 122.004 120.509 99.288  1.00 50.20  ? 148 ASN B C     1 
ATOM   5097  O  O     . ASN B 1 156 ? 120.993 120.054 98.738  1.00 53.16  ? 148 ASN B O     1 
ATOM   5098  C  CB    . ASN B 1 156 ? 121.851 122.360 100.976 1.00 51.17  ? 148 ASN B CB    1 
ATOM   5099  C  CG    . ASN B 1 156 ? 121.743 122.743 102.439 1.00 52.26  ? 148 ASN B CG    1 
ATOM   5100  O  OD1   . ASN B 1 156 ? 121.166 122.011 103.243 1.00 55.71  ? 148 ASN B OD1   1 
ATOM   5101  N  ND2   . ASN B 1 156 ? 122.296 123.898 102.792 1.00 51.70  ? 148 ASN B ND2   1 
ATOM   5102  N  N     . ALA B 1 157 ? 123.148 120.704 98.629  1.00 47.87  ? 149 ALA B N     1 
ATOM   5103  C  CA    . ALA B 1 157 ? 123.267 120.329 97.226  1.00 48.97  ? 149 ALA B CA    1 
ATOM   5104  C  C     . ALA B 1 157 ? 123.143 118.824 97.048  1.00 47.14  ? 149 ALA B C     1 
ATOM   5105  O  O     . ALA B 1 157 ? 122.625 118.356 96.031  1.00 46.62  ? 149 ALA B O     1 
ATOM   5106  C  CB    . ALA B 1 157 ? 124.592 120.830 96.658  1.00 52.65  ? 149 ALA B CB    1 
ATOM   5107  N  N     . SER B 1 158 ? 123.619 118.046 98.023  1.00 45.67  ? 150 SER B N     1 
ATOM   5108  C  CA    . SER B 1 158 ? 123.465 116.597 97.948  1.00 40.07  ? 150 SER B CA    1 
ATOM   5109  C  C     . SER B 1 158 ? 121.997 116.196 98.007  1.00 40.40  ? 150 SER B C     1 
ATOM   5110  O  O     . SER B 1 158 ? 121.544 115.350 97.229  1.00 45.28  ? 150 SER B O     1 
ATOM   5111  C  CB    . SER B 1 158 ? 124.253 115.929 99.072  1.00 39.17  ? 150 SER B CB    1 
ATOM   5112  O  OG    . SER B 1 158 ? 125.618 116.302 99.022  1.00 42.40  ? 150 SER B OG    1 
ATOM   5113  N  N     . ARG B 1 159 ? 121.233 116.803 98.915  1.00 38.44  ? 151 ARG B N     1 
ATOM   5114  C  CA    . ARG B 1 159 ? 119.800 116.523 98.964  1.00 40.16  ? 151 ARG B CA    1 
ATOM   5115  C  C     . ARG B 1 159 ? 119.115 116.943 97.668  1.00 44.20  ? 151 ARG B C     1 
ATOM   5116  O  O     . ARG B 1 159 ? 118.260 116.218 97.136  1.00 44.20  ? 151 ARG B O     1 
ATOM   5117  C  CB    . ARG B 1 159 ? 119.160 117.230 100.159 1.00 41.20  ? 151 ARG B CB    1 
ATOM   5118  C  CG    . ARG B 1 159 ? 119.660 116.760 101.512 1.00 38.12  ? 151 ARG B CG    1 
ATOM   5119  C  CD    . ARG B 1 159 ? 118.732 117.219 102.627 1.00 35.10  ? 151 ARG B CD    1 
ATOM   5120  N  NE    . ARG B 1 159 ? 118.490 118.656 102.583 1.00 40.83  ? 151 ARG B NE    1 
ATOM   5121  C  CZ    . ARG B 1 159 ? 119.225 119.559 103.216 1.00 40.75  ? 151 ARG B CZ    1 
ATOM   5122  N  NH1   . ARG B 1 159 ? 120.260 119.210 103.961 1.00 36.57  ? 151 ARG B NH1   1 
ATOM   5123  N  NH2   . ARG B 1 159 ? 118.913 120.846 103.098 1.00 45.20  ? 151 ARG B NH2   1 
ATOM   5124  N  N     . ASP B 1 160 ? 119.486 118.112 97.141  1.00 46.18  ? 152 ASP B N     1 
ATOM   5125  C  CA    . ASP B 1 160 ? 118.885 118.589 95.901  1.00 46.27  ? 152 ASP B CA    1 
ATOM   5126  C  C     . ASP B 1 160 ? 119.195 117.657 94.735  1.00 47.06  ? 152 ASP B C     1 
ATOM   5127  O  O     . ASP B 1 160 ? 118.320 117.380 93.908  1.00 51.28  ? 152 ASP B O     1 
ATOM   5128  C  CB    . ASP B 1 160 ? 119.366 120.006 95.597  1.00 50.55  ? 152 ASP B CB    1 
ATOM   5129  C  CG    . ASP B 1 160 ? 118.841 121.025 96.587  1.00 58.91  ? 152 ASP B CG    1 
ATOM   5130  O  OD1   . ASP B 1 160 ? 117.767 120.786 97.178  1.00 62.41  ? 152 ASP B OD1   1 
ATOM   5131  O  OD2   . ASP B 1 160 ? 119.502 122.068 96.771  1.00 61.79  ? 152 ASP B OD2   1 
ATOM   5132  N  N     . VAL B 1 161 ? 120.435 117.170 94.643  1.00 44.66  ? 153 VAL B N     1 
ATOM   5133  C  CA    . VAL B 1 161 ? 120.783 116.282 93.541  1.00 42.14  ? 153 VAL B CA    1 
ATOM   5134  C  C     . VAL B 1 161 ? 120.126 114.922 93.724  1.00 41.30  ? 153 VAL B C     1 
ATOM   5135  O  O     . VAL B 1 161 ? 119.810 114.250 92.741  1.00 44.26  ? 153 VAL B O     1 
ATOM   5136  C  CB    . VAL B 1 161 ? 122.312 116.172 93.376  1.00 38.67  ? 153 VAL B CB    1 
ATOM   5137  C  CG1   . VAL B 1 161 ? 122.933 115.410 94.515  1.00 42.02  ? 153 VAL B CG1   1 
ATOM   5138  C  CG2   . VAL B 1 161 ? 122.657 115.509 92.053  1.00 39.78  ? 153 VAL B CG2   1 
ATOM   5139  N  N     . VAL B 1 162 ? 119.886 114.497 94.967  1.00 42.04  ? 154 VAL B N     1 
ATOM   5140  C  CA    . VAL B 1 162 ? 119.098 113.285 95.183  1.00 44.31  ? 154 VAL B CA    1 
ATOM   5141  C  C     . VAL B 1 162 ? 117.694 113.468 94.626  1.00 46.71  ? 154 VAL B C     1 
ATOM   5142  O  O     . VAL B 1 162 ? 117.155 112.589 93.939  1.00 49.67  ? 154 VAL B O     1 
ATOM   5143  C  CB    . VAL B 1 162 ? 119.063 112.918 96.677  1.00 42.73  ? 154 VAL B CB    1 
ATOM   5144  C  CG1   . VAL B 1 162 ? 118.051 111.811 96.922  1.00 45.24  ? 154 VAL B CG1   1 
ATOM   5145  C  CG2   . VAL B 1 162 ? 120.428 112.487 97.146  1.00 41.25  ? 154 VAL B CG2   1 
ATOM   5146  N  N     . THR B 1 163 ? 117.081 114.618 94.913  1.00 45.06  ? 155 THR B N     1 
ATOM   5147  C  CA    . THR B 1 163 ? 115.747 114.893 94.383  1.00 45.06  ? 155 THR B CA    1 
ATOM   5148  C  C     . THR B 1 163 ? 115.755 114.926 92.858  1.00 48.31  ? 155 THR B C     1 
ATOM   5149  O  O     . THR B 1 163 ? 114.861 114.367 92.209  1.00 52.03  ? 155 THR B O     1 
ATOM   5150  C  CB    . THR B 1 163 ? 115.222 116.216 94.942  1.00 48.40  ? 155 THR B CB    1 
ATOM   5151  O  OG1   . THR B 1 163 ? 115.227 116.167 96.373  1.00 52.93  ? 155 THR B OG1   1 
ATOM   5152  C  CG2   . THR B 1 163 ? 113.805 116.472 94.459  1.00 58.02  ? 155 THR B CG2   1 
ATOM   5153  N  N     . LEU B 1 164 ? 116.765 115.572 92.272  1.00 46.59  ? 156 LEU B N     1 
ATOM   5154  C  CA    . LEU B 1 164 ? 116.865 115.652 90.818  1.00 42.73  ? 156 LEU B CA    1 
ATOM   5155  C  C     . LEU B 1 164 ? 117.041 114.274 90.194  1.00 43.07  ? 156 LEU B C     1 
ATOM   5156  O  O     . LEU B 1 164 ? 116.429 113.969 89.164  1.00 46.10  ? 156 LEU B O     1 
ATOM   5157  C  CB    . LEU B 1 164 ? 118.024 116.568 90.427  1.00 41.34  ? 156 LEU B CB    1 
ATOM   5158  C  CG    . LEU B 1 164 ? 118.528 116.489 88.986  1.00 41.65  ? 156 LEU B CG    1 
ATOM   5159  C  CD1   . LEU B 1 164 ? 117.446 116.887 88.001  1.00 45.70  ? 156 LEU B CD1   1 
ATOM   5160  C  CD2   . LEU B 1 164 ? 119.751 117.366 88.813  1.00 41.88  ? 156 LEU B CD2   1 
ATOM   5161  N  N     . VAL B 1 165 ? 117.883 113.432 90.794  1.00 41.98  ? 157 VAL B N     1 
ATOM   5162  C  CA    . VAL B 1 165 ? 118.097 112.091 90.267  1.00 42.18  ? 157 VAL B CA    1 
ATOM   5163  C  C     . VAL B 1 165 ? 116.823 111.266 90.372  1.00 43.88  ? 157 VAL B C     1 
ATOM   5164  O  O     . VAL B 1 165 ? 116.491 110.503 89.461  1.00 47.31  ? 157 VAL B O     1 
ATOM   5165  C  CB    . VAL B 1 165 ? 119.282 111.418 90.984  1.00 42.01  ? 157 VAL B CB    1 
ATOM   5166  C  CG1   . VAL B 1 165 ? 119.327 109.936 90.670  1.00 42.93  ? 157 VAL B CG1   1 
ATOM   5167  C  CG2   . VAL B 1 165 ? 120.585 112.078 90.569  1.00 38.65  ? 157 VAL B CG2   1 
ATOM   5168  N  N     . LYS B 1 166 ? 116.084 111.406 91.476  1.00 40.12  ? 158 LYS B N     1 
ATOM   5169  C  CA    . LYS B 1 166 ? 114.804 110.711 91.582  1.00 42.02  ? 158 LYS B CA    1 
ATOM   5170  C  C     . LYS B 1 166 ? 113.843 111.164 90.491  1.00 52.90  ? 158 LYS B C     1 
ATOM   5171  O  O     . LYS B 1 166 ? 113.168 110.338 89.861  1.00 60.90  ? 158 LYS B O     1 
ATOM   5172  C  CB    . LYS B 1 166 ? 114.187 110.941 92.961  1.00 49.80  ? 158 LYS B CB    1 
ATOM   5173  C  CG    . LYS B 1 166 ? 114.847 110.170 94.086  1.00 52.26  ? 158 LYS B CG    1 
ATOM   5174  C  CD    . LYS B 1 166 ? 114.111 110.390 95.394  1.00 43.50  ? 158 LYS B CD    1 
ATOM   5175  C  CE    . LYS B 1 166 ? 114.700 109.545 96.507  1.00 57.95  ? 158 LYS B CE    1 
ATOM   5176  N  NZ    . LYS B 1 166 ? 114.039 109.817 97.812  1.00 66.58  ? 158 LYS B NZ    1 
ATOM   5177  N  N     . SER B 1 167 ? 113.775 112.475 90.245  1.00 52.79  ? 159 SER B N     1 
ATOM   5178  C  CA    . SER B 1 167 ? 112.884 112.987 89.209  1.00 53.75  ? 159 SER B CA    1 
ATOM   5179  C  C     . SER B 1 167 ? 113.276 112.462 87.834  1.00 54.61  ? 159 SER B C     1 
ATOM   5180  O  O     . SER B 1 167 ? 112.412 112.072 87.041  1.00 58.45  ? 159 SER B O     1 
ATOM   5181  C  CB    . SER B 1 167 ? 112.892 114.514 89.216  1.00 52.75  ? 159 SER B CB    1 
ATOM   5182  O  OG    . SER B 1 167 ? 114.161 115.015 88.836  1.00 48.55  ? 159 SER B OG    1 
ATOM   5183  N  N     . VAL B 1 168 ? 114.576 112.447 87.534  1.00 51.24  ? 160 VAL B N     1 
ATOM   5184  C  CA    . VAL B 1 168 ? 115.038 111.959 86.237  1.00 50.94  ? 160 VAL B CA    1 
ATOM   5185  C  C     . VAL B 1 168 ? 114.751 110.471 86.090  1.00 55.97  ? 160 VAL B C     1 
ATOM   5186  O  O     . VAL B 1 168 ? 114.301 110.013 85.033  1.00 65.18  ? 160 VAL B O     1 
ATOM   5187  C  CB    . VAL B 1 168 ? 116.534 112.272 86.051  1.00 49.70  ? 160 VAL B CB    1 
ATOM   5188  C  CG1   . VAL B 1 168 ? 117.061 111.610 84.793  1.00 48.51  ? 160 VAL B CG1   1 
ATOM   5189  C  CG2   . VAL B 1 168 ? 116.754 113.771 85.986  1.00 44.65  ? 160 VAL B CG2   1 
ATOM   5190  N  N     . LEU B 1 169 ? 115.001 109.692 87.144  1.00 51.04  ? 161 LEU B N     1 
ATOM   5191  C  CA    . LEU B 1 169 ? 114.813 108.249 87.060  1.00 56.38  ? 161 LEU B CA    1 
ATOM   5192  C  C     . LEU B 1 169 ? 113.342 107.869 86.986  1.00 60.65  ? 161 LEU B C     1 
ATOM   5193  O  O     . LEU B 1 169 ? 113.007 106.808 86.448  1.00 67.72  ? 161 LEU B O     1 
ATOM   5194  C  CB    . LEU B 1 169 ? 115.475 107.560 88.253  1.00 58.93  ? 161 LEU B CB    1 
ATOM   5195  C  CG    . LEU B 1 169 ? 117.003 107.578 88.298  1.00 58.07  ? 161 LEU B CG    1 
ATOM   5196  C  CD1   . LEU B 1 169 ? 117.511 106.930 89.573  1.00 54.99  ? 161 LEU B CD1   1 
ATOM   5197  C  CD2   . LEU B 1 169 ? 117.576 106.879 87.086  1.00 59.89  ? 161 LEU B CD2   1 
ATOM   5198  N  N     . PHE B 1 170 ? 112.450 108.704 87.523  1.00 60.28  ? 162 PHE B N     1 
ATOM   5199  C  CA    . PHE B 1 170 ? 111.030 108.377 87.459  1.00 66.55  ? 162 PHE B CA    1 
ATOM   5200  C  C     . PHE B 1 170 ? 110.486 108.404 86.035  1.00 68.66  ? 162 PHE B C     1 
ATOM   5201  O  O     . PHE B 1 170 ? 109.456 107.775 85.769  1.00 69.72  ? 162 PHE B O     1 
ATOM   5202  C  CB    . PHE B 1 170 ? 110.226 109.332 88.342  1.00 71.87  ? 162 PHE B CB    1 
ATOM   5203  C  CG    . PHE B 1 170 ? 108.800 108.909 88.547  1.00 79.64  ? 162 PHE B CG    1 
ATOM   5204  C  CD1   . PHE B 1 170 ? 108.484 107.916 89.460  1.00 79.58  ? 162 PHE B CD1   1 
ATOM   5205  C  CD2   . PHE B 1 170 ? 107.775 109.504 87.830  1.00 74.77  ? 162 PHE B CD2   1 
ATOM   5206  C  CE1   . PHE B 1 170 ? 107.174 107.523 89.652  1.00 77.63  ? 162 PHE B CE1   1 
ATOM   5207  C  CE2   . PHE B 1 170 ? 106.462 109.115 88.018  1.00 75.23  ? 162 PHE B CE2   1 
ATOM   5208  C  CZ    . PHE B 1 170 ? 106.162 108.124 88.930  1.00 78.51  ? 162 PHE B CZ    1 
ATOM   5209  N  N     . HIS B 1 171 ? 111.151 109.104 85.116  1.00 66.30  ? 163 HIS B N     1 
ATOM   5210  C  CA    . HIS B 1 171 ? 110.685 109.220 83.742  1.00 66.72  ? 163 HIS B CA    1 
ATOM   5211  C  C     . HIS B 1 171 ? 111.638 108.619 82.718  1.00 69.82  ? 163 HIS B C     1 
ATOM   5212  O  O     . HIS B 1 171 ? 111.330 108.651 81.521  1.00 72.40  ? 163 HIS B O     1 
ATOM   5213  C  CB    . HIS B 1 171 ? 110.439 110.691 83.384  1.00 69.67  ? 163 HIS B CB    1 
ATOM   5214  C  CG    . HIS B 1 171 ? 109.353 111.339 84.184  1.00 71.62  ? 163 HIS B CG    1 
ATOM   5215  N  ND1   . HIS B 1 171 ? 109.515 111.704 85.503  1.00 71.28  ? 163 HIS B ND1   1 
ATOM   5216  C  CD2   . HIS B 1 171 ? 108.090 111.694 83.849  1.00 70.13  ? 163 HIS B CD2   1 
ATOM   5217  C  CE1   . HIS B 1 171 ? 108.399 112.254 85.946  1.00 73.12  ? 163 HIS B CE1   1 
ATOM   5218  N  NE2   . HIS B 1 171 ? 107.518 112.259 84.962  1.00 74.83  ? 163 HIS B NE2   1 
ATOM   5219  N  N     . ARG B 1 172 ? 112.775 108.076 83.141  1.00 68.89  ? 164 ARG B N     1 
ATOM   5220  C  CA    . ARG B 1 172 ? 113.784 107.618 82.196  1.00 68.26  ? 164 ARG B CA    1 
ATOM   5221  C  C     . ARG B 1 172 ? 113.310 106.389 81.427  1.00 76.82  ? 164 ARG B C     1 
ATOM   5222  O  O     . ARG B 1 172 ? 112.502 105.593 81.912  1.00 81.99  ? 164 ARG B O     1 
ATOM   5223  C  CB    . ARG B 1 172 ? 115.088 107.289 82.921  1.00 67.25  ? 164 ARG B CB    1 
ATOM   5224  C  CG    . ARG B 1 172 ? 114.988 106.080 83.831  1.00 66.39  ? 164 ARG B CG    1 
ATOM   5225  C  CD    . ARG B 1 172 ? 116.325 105.387 83.987  1.00 62.52  ? 164 ARG B CD    1 
ATOM   5226  N  NE    . ARG B 1 172 ? 116.209 104.178 84.793  1.00 64.47  ? 164 ARG B NE    1 
ATOM   5227  C  CZ    . ARG B 1 172 ? 117.208 103.342 85.035  1.00 70.38  ? 164 ARG B CZ    1 
ATOM   5228  N  NH1   . ARG B 1 172 ? 118.419 103.552 84.544  1.00 67.70  ? 164 ARG B NH1   1 
ATOM   5229  N  NH2   . ARG B 1 172 ? 116.988 102.268 85.787  1.00 71.02  ? 164 ARG B NH2   1 
ATOM   5230  N  N     . ARG B 1 173 ? 113.824 106.250 80.203  1.00 78.01  ? 165 ARG B N     1 
ATOM   5231  C  CA    . ARG B 1 173 ? 113.617 105.049 79.406  1.00 78.13  ? 165 ARG B CA    1 
ATOM   5232  C  C     . ARG B 1 173 ? 114.885 104.573 78.713  1.00 82.15  ? 165 ARG B C     1 
ATOM   5233  O  O     . ARG B 1 173 ? 114.829 103.582 77.978  1.00 87.06  ? 165 ARG B O     1 
ATOM   5234  C  CB    . ARG B 1 173 ? 112.519 105.278 78.353  1.00 80.92  ? 165 ARG B CB    1 
ATOM   5235  C  CG    . ARG B 1 173 ? 111.145 105.563 78.936  1.00 80.48  ? 165 ARG B CG    1 
ATOM   5236  C  CD    . ARG B 1 173 ? 110.123 105.815 77.844  1.00 89.25  ? 165 ARG B CD    1 
ATOM   5237  N  NE    . ARG B 1 173 ? 108.853 106.283 78.387  1.00 93.30  ? 165 ARG B NE    1 
ATOM   5238  C  CZ    . ARG B 1 173 ? 107.808 106.635 77.651  1.00 93.01  ? 165 ARG B CZ    1 
ATOM   5239  N  NH1   . ARG B 1 173 ? 107.841 106.575 76.330  1.00 89.00  ? 165 ARG B NH1   1 
ATOM   5240  N  NH2   . ARG B 1 173 ? 106.702 107.060 78.255  1.00 91.00  ? 165 ARG B NH2   1 
ATOM   5241  N  N     . ASN B 1 174 ? 116.014 105.236 78.919  1.00 78.96  ? 166 ASN B N     1 
ATOM   5242  C  CA    . ASN B 1 174 ? 117.290 104.913 78.305  1.00 77.56  ? 166 ASN B CA    1 
ATOM   5243  C  C     . ASN B 1 174 ? 118.364 104.872 79.379  1.00 78.83  ? 166 ASN B C     1 
ATOM   5244  O  O     . ASN B 1 174 ? 118.192 105.448 80.459  1.00 78.55  ? 166 ASN B O     1 
ATOM   5245  C  CB    . ASN B 1 174 ? 117.659 105.948 77.232  1.00 80.82  ? 166 ASN B CB    1 
ATOM   5246  C  CG    . ASN B 1 174 ? 116.722 105.913 76.043  1.00 89.81  ? 166 ASN B CG    1 
ATOM   5247  O  OD1   . ASN B 1 174 ? 115.589 106.383 76.118  1.00 90.66  ? 166 ASN B OD1   1 
ATOM   5248  N  ND2   . ASN B 1 174 ? 117.194 105.357 74.933  1.00 96.04  ? 166 ASN B ND2   1 
ATOM   5249  N  N     . PRO B 1 175 ? 119.478 104.185 79.124  1.00 78.98  ? 167 PRO B N     1 
ATOM   5250  C  CA    . PRO B 1 175 ? 120.560 104.147 80.115  1.00 72.63  ? 167 PRO B CA    1 
ATOM   5251  C  C     . PRO B 1 175 ? 121.070 105.543 80.441  1.00 67.85  ? 167 PRO B C     1 
ATOM   5252  O  O     . PRO B 1 175 ? 121.127 106.422 79.580  1.00 69.15  ? 167 PRO B O     1 
ATOM   5253  C  CB    . PRO B 1 175 ? 121.637 103.300 79.430  1.00 74.28  ? 167 PRO B CB    1 
ATOM   5254  C  CG    . PRO B 1 175 ? 120.878 102.434 78.491  1.00 81.04  ? 167 PRO B CG    1 
ATOM   5255  C  CD    . PRO B 1 175 ? 119.737 103.273 77.995  1.00 79.66  ? 167 PRO B CD    1 
ATOM   5256  N  N     . LEU B 1 176 ? 121.438 105.740 81.705  1.00 62.57  ? 168 LEU B N     1 
ATOM   5257  C  CA    . LEU B 1 176 ? 121.843 107.042 82.215  1.00 57.86  ? 168 LEU B CA    1 
ATOM   5258  C  C     . LEU B 1 176 ? 123.260 106.974 82.764  1.00 54.40  ? 168 LEU B C     1 
ATOM   5259  O  O     . LEU B 1 176 ? 123.609 106.038 83.495  1.00 56.97  ? 168 LEU B O     1 
ATOM   5260  C  CB    . LEU B 1 176 ? 120.879 107.529 83.298  1.00 56.92  ? 168 LEU B CB    1 
ATOM   5261  C  CG    . LEU B 1 176 ? 119.545 108.082 82.797  1.00 55.90  ? 168 LEU B CG    1 
ATOM   5262  C  CD1   . LEU B 1 176 ? 118.606 108.344 83.954  1.00 55.99  ? 168 LEU B CD1   1 
ATOM   5263  C  CD2   . LEU B 1 176 ? 119.770 109.353 82.000  1.00 58.55  ? 168 LEU B CD2   1 
ATOM   5264  N  N     . HIS B 1 177 ? 124.068 107.970 82.411  1.00 52.55  ? 169 HIS B N     1 
ATOM   5265  C  CA    . HIS B 1 177 ? 125.435 108.103 82.896  1.00 49.86  ? 169 HIS B CA    1 
ATOM   5266  C  C     . HIS B 1 177 ? 125.565 109.478 83.537  1.00 47.10  ? 169 HIS B C     1 
ATOM   5267  O  O     . HIS B 1 177 ? 125.561 110.498 82.840  1.00 51.29  ? 169 HIS B O     1 
ATOM   5268  C  CB    . HIS B 1 177 ? 126.441 107.917 81.760  1.00 51.62  ? 169 HIS B CB    1 
ATOM   5269  C  CG    . HIS B 1 177 ? 127.860 107.786 82.219  1.00 54.13  ? 169 HIS B CG    1 
ATOM   5270  N  ND1   . HIS B 1 177 ? 128.776 106.981 81.578  1.00 57.03  ? 169 HIS B ND1   1 
ATOM   5271  C  CD2   . HIS B 1 177 ? 128.523 108.363 83.249  1.00 53.53  ? 169 HIS B CD2   1 
ATOM   5272  C  CE1   . HIS B 1 177 ? 129.941 107.064 82.195  1.00 58.41  ? 169 HIS B CE1   1 
ATOM   5273  N  NE2   . HIS B 1 177 ? 129.814 107.896 83.213  1.00 55.96  ? 169 HIS B NE2   1 
ATOM   5274  N  N     . PHE B 1 178 ? 125.679 109.501 84.859  1.00 44.51  ? 170 PHE B N     1 
ATOM   5275  C  CA    . PHE B 1 178 ? 125.810 110.740 85.609  1.00 41.22  ? 170 PHE B CA    1 
ATOM   5276  C  C     . PHE B 1 178 ? 127.280 111.078 85.806  1.00 41.83  ? 170 PHE B C     1 
ATOM   5277  O  O     . PHE B 1 178 ? 128.084 110.212 86.166  1.00 51.19  ? 170 PHE B O     1 
ATOM   5278  C  CB    . PHE B 1 178 ? 125.106 110.632 86.961  1.00 41.12  ? 170 PHE B CB    1 
ATOM   5279  C  CG    . PHE B 1 178 ? 123.615 110.501 86.860  1.00 43.50  ? 170 PHE B CG    1 
ATOM   5280  C  CD1   . PHE B 1 178 ? 122.827 111.607 86.602  1.00 43.08  ? 170 PHE B CD1   1 
ATOM   5281  C  CD2   . PHE B 1 178 ? 123.001 109.273 87.028  1.00 44.48  ? 170 PHE B CD2   1 
ATOM   5282  C  CE1   . PHE B 1 178 ? 121.457 111.490 86.509  1.00 40.60  ? 170 PHE B CE1   1 
ATOM   5283  C  CE2   . PHE B 1 178 ? 121.631 109.152 86.937  1.00 45.18  ? 170 PHE B CE2   1 
ATOM   5284  C  CZ    . PHE B 1 178 ? 120.858 110.261 86.677  1.00 42.27  ? 170 PHE B CZ    1 
ATOM   5285  N  N     . HIS B 1 179 ? 127.623 112.334 85.549  1.00 39.01  ? 171 HIS B N     1 
ATOM   5286  C  CA    . HIS B 1 179 ? 128.959 112.877 85.764  1.00 41.24  ? 171 HIS B CA    1 
ATOM   5287  C  C     . HIS B 1 179 ? 128.815 113.953 86.833  1.00 43.94  ? 171 HIS B C     1 
ATOM   5288  O  O     . HIS B 1 179 ? 128.327 115.053 86.554  1.00 50.61  ? 171 HIS B O     1 
ATOM   5289  C  CB    . HIS B 1 179 ? 129.542 113.439 84.471  1.00 45.96  ? 171 HIS B CB    1 
ATOM   5290  C  CG    . HIS B 1 179 ? 129.540 112.466 83.333  1.00 51.40  ? 171 HIS B CG    1 
ATOM   5291  N  ND1   . HIS B 1 179 ? 130.694 111.902 82.834  1.00 56.88  ? 171 HIS B ND1   1 
ATOM   5292  C  CD2   . HIS B 1 179 ? 128.524 111.955 82.598  1.00 51.89  ? 171 HIS B CD2   1 
ATOM   5293  C  CE1   . HIS B 1 179 ? 130.389 111.087 81.840  1.00 58.01  ? 171 HIS B CE1   1 
ATOM   5294  N  NE2   . HIS B 1 179 ? 129.079 111.101 81.677  1.00 54.27  ? 171 HIS B NE2   1 
ATOM   5295  N  N     . LEU B 1 180 ? 129.219 113.634 88.057  1.00 41.40  ? 172 LEU B N     1 
ATOM   5296  C  CA    . LEU B 1 180 ? 129.015 114.511 89.201  1.00 42.12  ? 172 LEU B CA    1 
ATOM   5297  C  C     . LEU B 1 180 ? 130.323 115.227 89.509  1.00 45.45  ? 172 LEU B C     1 
ATOM   5298  O  O     . LEU B 1 180 ? 131.284 114.608 89.974  1.00 52.89  ? 172 LEU B O     1 
ATOM   5299  C  CB    . LEU B 1 180 ? 128.522 113.714 90.405  1.00 43.75  ? 172 LEU B CB    1 
ATOM   5300  C  CG    . LEU B 1 180 ? 127.303 112.831 90.134  1.00 39.73  ? 172 LEU B CG    1 
ATOM   5301  C  CD1   . LEU B 1 180 ? 126.862 112.121 91.397  1.00 34.94  ? 172 LEU B CD1   1 
ATOM   5302  C  CD2   . LEU B 1 180 ? 126.167 113.655 89.558  1.00 41.88  ? 172 LEU B CD2   1 
ATOM   5303  N  N     . ILE B 1 181 ? 130.359 116.529 89.241  1.00 45.70  ? 173 ILE B N     1 
ATOM   5304  C  CA    . ILE B 1 181 ? 131.488 117.368 89.633  1.00 52.04  ? 173 ILE B CA    1 
ATOM   5305  C  C     . ILE B 1 181 ? 131.231 117.781 91.078  1.00 58.26  ? 173 ILE B C     1 
ATOM   5306  O  O     . ILE B 1 181 ? 130.371 118.620 91.351  1.00 61.37  ? 173 ILE B O     1 
ATOM   5307  C  CB    . ILE B 1 181 ? 131.657 118.580 88.714  1.00 54.36  ? 173 ILE B CB    1 
ATOM   5308  C  CG1   . ILE B 1 181 ? 132.075 118.144 87.306  1.00 55.10  ? 173 ILE B CG1   1 
ATOM   5309  C  CG2   . ILE B 1 181 ? 132.681 119.545 89.287  1.00 61.41  ? 173 ILE B CG2   1 
ATOM   5310  C  CD1   . ILE B 1 181 ? 130.923 117.768 86.396  1.00 54.65  ? 173 ILE B CD1   1 
ATOM   5311  N  N     . ALA B 1 182 ? 131.957 117.173 92.015  1.00 59.96  ? 174 ALA B N     1 
ATOM   5312  C  CA    . ALA B 1 182 ? 131.665 117.360 93.426  1.00 64.83  ? 174 ALA B CA    1 
ATOM   5313  C  C     . ALA B 1 182 ? 132.953 117.448 94.229  1.00 72.28  ? 174 ALA B C     1 
ATOM   5314  O  O     . ALA B 1 182 ? 133.971 116.850 93.871  1.00 75.52  ? 174 ALA B O     1 
ATOM   5315  C  CB    . ALA B 1 182 ? 130.792 116.222 93.972  1.00 60.73  ? 174 ALA B CB    1 
ATOM   5316  N  N     . ASP B 1 183 ? 132.893 118.203 95.322  1.00 72.46  ? 175 ASP B N     1 
ATOM   5317  C  CA    . ASP B 1 183 ? 133.972 118.216 96.292  1.00 77.50  ? 175 ASP B CA    1 
ATOM   5318  C  C     . ASP B 1 183 ? 133.879 116.980 97.183  1.00 76.42  ? 175 ASP B C     1 
ATOM   5319  O  O     . ASP B 1 183 ? 132.925 116.203 97.112  1.00 75.56  ? 175 ASP B O     1 
ATOM   5320  C  CB    . ASP B 1 183 ? 133.925 119.491 97.131  1.00 81.74  ? 175 ASP B CB    1 
ATOM   5321  C  CG    . ASP B 1 183 ? 132.647 119.613 97.933  1.00 79.97  ? 175 ASP B CG    1 
ATOM   5322  O  OD1   . ASP B 1 183 ? 131.621 119.046 97.505  1.00 78.22  ? 175 ASP B OD1   1 
ATOM   5323  O  OD2   . ASP B 1 183 ? 132.667 120.277 98.990  1.00 82.33  ? 175 ASP B OD2   1 
ATOM   5324  N  N     . SER B 1 184 ? 134.883 116.814 98.047  1.00 77.43  ? 176 SER B N     1 
ATOM   5325  C  CA    . SER B 1 184 ? 134.969 115.603 98.860  1.00 74.43  ? 176 SER B CA    1 
ATOM   5326  C  C     . SER B 1 184 ? 133.748 115.444 99.757  1.00 70.26  ? 176 SER B C     1 
ATOM   5327  O  O     . SER B 1 184 ? 133.230 114.332 99.920  1.00 67.24  ? 176 SER B O     1 
ATOM   5328  C  CB    . SER B 1 184 ? 136.249 115.625 99.694  1.00 81.72  ? 176 SER B CB    1 
ATOM   5329  O  OG    . SER B 1 184 ? 136.302 116.782 100.510 1.00 88.61  ? 176 SER B OG    1 
ATOM   5330  N  N     . ILE B 1 185 ? 133.272 116.548 100.341 1.00 70.55  ? 177 ILE B N     1 
ATOM   5331  C  CA    . ILE B 1 185 ? 132.116 116.491 101.234 1.00 69.88  ? 177 ILE B CA    1 
ATOM   5332  C  C     . ILE B 1 185 ? 130.913 115.900 100.511 1.00 64.90  ? 177 ILE B C     1 
ATOM   5333  O  O     . ILE B 1 185 ? 130.251 114.985 101.013 1.00 62.38  ? 177 ILE B O     1 
ATOM   5334  C  CB    . ILE B 1 185 ? 131.803 117.891 101.791 1.00 69.58  ? 177 ILE B CB    1 
ATOM   5335  C  CG1   . ILE B 1 185 ? 132.882 118.328 102.782 1.00 71.26  ? 177 ILE B CG1   1 
ATOM   5336  C  CG2   . ILE B 1 185 ? 130.430 117.914 102.437 1.00 63.66  ? 177 ILE B CG2   1 
ATOM   5337  C  CD1   . ILE B 1 185 ? 132.621 119.680 103.408 1.00 66.54  ? 177 ILE B CD1   1 
ATOM   5338  N  N     . ALA B 1 186 ? 130.614 116.412 99.318  1.00 66.02  ? 178 ALA B N     1 
ATOM   5339  C  CA    . ALA B 1 186 ? 129.516 115.862 98.535  1.00 61.39  ? 178 ALA B CA    1 
ATOM   5340  C  C     . ALA B 1 186 ? 129.887 114.537 97.885  1.00 58.93  ? 178 ALA B C     1 
ATOM   5341  O  O     . ALA B 1 186 ? 129.012 113.685 97.687  1.00 53.05  ? 178 ALA B O     1 
ATOM   5342  C  CB    . ALA B 1 186 ? 129.077 116.865 97.468  1.00 58.44  ? 178 ALA B CB    1 
ATOM   5343  N  N     . GLU B 1 187 ? 131.164 114.353 97.537  1.00 65.28  ? 179 GLU B N     1 
ATOM   5344  C  CA    . GLU B 1 187 ? 131.577 113.131 96.855  1.00 61.69  ? 179 GLU B CA    1 
ATOM   5345  C  C     . GLU B 1 187 ? 131.361 111.907 97.730  1.00 55.99  ? 179 GLU B C     1 
ATOM   5346  O  O     . GLU B 1 187 ? 130.858 110.884 97.256  1.00 51.78  ? 179 GLU B O     1 
ATOM   5347  C  CB    . GLU B 1 187 ? 133.041 113.225 96.431  1.00 66.35  ? 179 GLU B CB    1 
ATOM   5348  C  CG    . GLU B 1 187 ? 133.563 111.975 95.748  1.00 69.47  ? 179 GLU B CG    1 
ATOM   5349  C  CD    . GLU B 1 187 ? 135.002 112.117 95.298  1.00 82.78  ? 179 GLU B CD    1 
ATOM   5350  O  OE1   . GLU B 1 187 ? 135.559 113.227 95.431  1.00 88.31  ? 179 GLU B OE1   1 
ATOM   5351  O  OE2   . GLU B 1 187 ? 135.575 111.120 94.813  1.00 88.50  ? 179 GLU B OE2   1 
ATOM   5352  N  N     . GLN B 1 188 ? 131.736 111.987 99.009  1.00 59.92  ? 180 GLN B N     1 
ATOM   5353  C  CA    . GLN B 1 188 ? 131.550 110.847 99.903  1.00 58.42  ? 180 GLN B CA    1 
ATOM   5354  C  C     . GLN B 1 188 ? 130.075 110.491 100.035 1.00 53.67  ? 180 GLN B C     1 
ATOM   5355  O  O     . GLN B 1 188 ? 129.689 109.318 99.920  1.00 53.01  ? 180 GLN B O     1 
ATOM   5356  C  CB    . GLN B 1 188 ? 132.152 111.158 101.273 1.00 54.68  ? 180 GLN B CB    1 
ATOM   5357  C  CG    . GLN B 1 188 ? 131.892 110.089 102.319 1.00 55.01  ? 180 GLN B CG    1 
ATOM   5358  C  CD    . GLN B 1 188 ? 132.375 110.494 103.696 1.00 63.81  ? 180 GLN B CD    1 
ATOM   5359  O  OE1   . GLN B 1 188 ? 132.889 111.595 103.887 1.00 66.92  ? 180 GLN B OE1   1 
ATOM   5360  N  NE2   . GLN B 1 188 ? 132.210 109.603 104.666 1.00 64.22  ? 180 GLN B NE2   1 
ATOM   5361  N  N     . ILE B 1 189 ? 129.233 111.502 100.256 1.00 49.63  ? 181 ILE B N     1 
ATOM   5362  C  CA    . ILE B 1 189 ? 127.804 111.270 100.437 1.00 44.48  ? 181 ILE B CA    1 
ATOM   5363  C  C     . ILE B 1 189 ? 127.208 110.634 99.191  1.00 46.87  ? 181 ILE B C     1 
ATOM   5364  O  O     . ILE B 1 189 ? 126.499 109.624 99.267  1.00 45.44  ? 181 ILE B O     1 
ATOM   5365  C  CB    . ILE B 1 189 ? 127.090 112.587 100.782 1.00 42.79  ? 181 ILE B CB    1 
ATOM   5366  C  CG1   . ILE B 1 189 ? 127.680 113.198 102.050 1.00 44.36  ? 181 ILE B CG1   1 
ATOM   5367  C  CG2   . ILE B 1 189 ? 125.595 112.357 100.927 1.00 38.58  ? 181 ILE B CG2   1 
ATOM   5368  C  CD1   . ILE B 1 189 ? 127.178 114.585 102.330 1.00 42.49  ? 181 ILE B CD1   1 
ATOM   5369  N  N     . LEU B 1 190 ? 127.495 111.213 98.023  1.00 48.35  ? 182 LEU B N     1 
ATOM   5370  C  CA    . LEU B 1 190 ? 126.894 110.715 96.791  1.00 43.23  ? 182 LEU B CA    1 
ATOM   5371  C  C     . LEU B 1 190 ? 127.428 109.336 96.430  1.00 45.51  ? 182 LEU B C     1 
ATOM   5372  O  O     . LEU B 1 190 ? 126.674 108.484 95.948  1.00 47.61  ? 182 LEU B O     1 
ATOM   5373  C  CB    . LEU B 1 190 ? 127.131 111.708 95.657  1.00 41.73  ? 182 LEU B CB    1 
ATOM   5374  C  CG    . LEU B 1 190 ? 126.372 113.024 95.819  1.00 40.00  ? 182 LEU B CG    1 
ATOM   5375  C  CD1   . LEU B 1 190 ? 126.620 113.948 94.641  1.00 44.43  ? 182 LEU B CD1   1 
ATOM   5376  C  CD2   . LEU B 1 190 ? 124.889 112.749 95.989  1.00 39.21  ? 182 LEU B CD2   1 
ATOM   5377  N  N     . ALA B 1 191 ? 128.719 109.091 96.662  1.00 46.22  ? 183 ALA B N     1 
ATOM   5378  C  CA    . ALA B 1 191 ? 129.285 107.780 96.377  1.00 44.34  ? 183 ALA B CA    1 
ATOM   5379  C  C     . ALA B 1 191 ? 128.632 106.710 97.236  1.00 42.92  ? 183 ALA B C     1 
ATOM   5380  O  O     . ALA B 1 191 ? 128.226 105.657 96.731  1.00 48.14  ? 183 ALA B O     1 
ATOM   5381  C  CB    . ALA B 1 191 ? 130.797 107.805 96.597  1.00 46.84  ? 183 ALA B CB    1 
ATOM   5382  N  N     . THR B 1 192 ? 128.499 106.969 98.540  1.00 42.81  ? 184 THR B N     1 
ATOM   5383  C  CA    . THR B 1 192 ? 127.840 106.000 99.409  1.00 45.47  ? 184 THR B CA    1 
ATOM   5384  C  C     . THR B 1 192 ? 126.381 105.808 99.011  1.00 44.35  ? 184 THR B C     1 
ATOM   5385  O  O     . THR B 1 192 ? 125.879 104.676 98.981  1.00 44.05  ? 184 THR B O     1 
ATOM   5386  C  CB    . THR B 1 192 ? 127.945 106.445 100.866 1.00 42.29  ? 184 THR B CB    1 
ATOM   5387  O  OG1   . THR B 1 192 ? 129.321 106.662 101.201 1.00 44.67  ? 184 THR B OG1   1 
ATOM   5388  C  CG2   . THR B 1 192 ? 127.366 105.384 101.789 1.00 38.48  ? 184 THR B CG2   1 
ATOM   5389  N  N     . LEU B 1 193 ? 125.691 106.905 98.686  1.00 41.85  ? 185 LEU B N     1 
ATOM   5390  C  CA    . LEU B 1 193 ? 124.278 106.826 98.336  1.00 38.36  ? 185 LEU B CA    1 
ATOM   5391  C  C     . LEU B 1 193 ? 124.063 105.989 97.084  1.00 44.54  ? 185 LEU B C     1 
ATOM   5392  O  O     . LEU B 1 193 ? 123.170 105.137 97.041  1.00 46.79  ? 185 LEU B O     1 
ATOM   5393  C  CB    . LEU B 1 193 ? 123.714 108.230 98.138  1.00 35.53  ? 185 LEU B CB    1 
ATOM   5394  C  CG    . LEU B 1 193 ? 122.371 108.287 97.412  1.00 36.67  ? 185 LEU B CG    1 
ATOM   5395  C  CD1   . LEU B 1 193 ? 121.211 108.156 98.385  1.00 35.62  ? 185 LEU B CD1   1 
ATOM   5396  C  CD2   . LEU B 1 193 ? 122.268 109.559 96.601  1.00 43.73  ? 185 LEU B CD2   1 
ATOM   5397  N  N     . PHE B 1 194 ? 124.873 106.215 96.050  1.00 48.79  ? 186 PHE B N     1 
ATOM   5398  C  CA    . PHE B 1 194 ? 124.704 105.464 94.813  1.00 42.57  ? 186 PHE B CA    1 
ATOM   5399  C  C     . PHE B 1 194 ? 125.211 104.036 94.937  1.00 45.28  ? 186 PHE B C     1 
ATOM   5400  O  O     . PHE B 1 194 ? 124.683 103.141 94.269  1.00 50.53  ? 186 PHE B O     1 
ATOM   5401  C  CB    . PHE B 1 194 ? 125.398 106.183 93.658  1.00 41.57  ? 186 PHE B CB    1 
ATOM   5402  C  CG    . PHE B 1 194 ? 124.670 107.407 93.189  1.00 46.53  ? 186 PHE B CG    1 
ATOM   5403  C  CD1   . PHE B 1 194 ? 123.388 107.307 92.678  1.00 49.50  ? 186 PHE B CD1   1 
ATOM   5404  C  CD2   . PHE B 1 194 ? 125.263 108.654 93.255  1.00 48.53  ? 186 PHE B CD2   1 
ATOM   5405  C  CE1   . PHE B 1 194 ? 122.712 108.427 92.247  1.00 48.68  ? 186 PHE B CE1   1 
ATOM   5406  C  CE2   . PHE B 1 194 ? 124.591 109.778 92.825  1.00 47.46  ? 186 PHE B CE2   1 
ATOM   5407  C  CZ    . PHE B 1 194 ? 123.315 109.664 92.319  1.00 47.55  ? 186 PHE B CZ    1 
ATOM   5408  N  N     . GLN B 1 195 ? 126.221 103.797 95.777  1.00 45.40  ? 187 GLN B N     1 
ATOM   5409  C  CA    . GLN B 1 195 ? 126.653 102.429 96.031  1.00 51.58  ? 187 GLN B CA    1 
ATOM   5410  C  C     . GLN B 1 195 ? 125.554 101.625 96.709  1.00 50.84  ? 187 GLN B C     1 
ATOM   5411  O  O     . GLN B 1 195 ? 125.308 100.467 96.351  1.00 58.35  ? 187 GLN B O     1 
ATOM   5412  C  CB    . GLN B 1 195 ? 127.920 102.435 96.884  1.00 55.97  ? 187 GLN B CB    1 
ATOM   5413  C  CG    . GLN B 1 195 ? 128.381 101.062 97.325  1.00 66.37  ? 187 GLN B CG    1 
ATOM   5414  C  CD    . GLN B 1 195 ? 129.570 101.124 98.262  1.00 81.52  ? 187 GLN B CD    1 
ATOM   5415  O  OE1   . GLN B 1 195 ? 130.012 102.205 98.650  1.00 82.56  ? 187 GLN B OE1   1 
ATOM   5416  N  NE2   . GLN B 1 195 ? 130.095 99.961  98.631  1.00 86.12  ? 187 GLN B NE2   1 
ATOM   5417  N  N     . THR B 1 196 ? 124.876 102.223 97.690  1.00 48.25  ? 188 THR B N     1 
ATOM   5418  C  CA    . THR B 1 196 ? 123.812 101.521 98.395  1.00 48.86  ? 188 THR B CA    1 
ATOM   5419  C  C     . THR B 1 196 ? 122.487 101.531 97.642  1.00 48.86  ? 188 THR B C     1 
ATOM   5420  O  O     . THR B 1 196 ? 121.610 100.717 97.950  1.00 51.35  ? 188 THR B O     1 
ATOM   5421  C  CB    . THR B 1 196 ? 123.618 102.134 99.781  1.00 44.56  ? 188 THR B CB    1 
ATOM   5422  O  OG1   . THR B 1 196 ? 123.401 103.543 99.652  1.00 45.07  ? 188 THR B OG1   1 
ATOM   5423  C  CG2   . THR B 1 196 ? 124.845 101.899 100.640 1.00 45.51  ? 188 THR B CG2   1 
ATOM   5424  N  N     . TRP B 1 197 ? 122.321 102.425 96.667  1.00 48.55  ? 189 TRP B N     1 
ATOM   5425  C  CA    . TRP B 1 197 ? 121.043 102.557 95.978  1.00 50.12  ? 189 TRP B CA    1 
ATOM   5426  C  C     . TRP B 1 197 ? 120.806 101.415 94.997  1.00 55.94  ? 189 TRP B C     1 
ATOM   5427  O  O     . TRP B 1 197 ? 119.692 100.886 94.918  1.00 57.57  ? 189 TRP B O     1 
ATOM   5428  C  CB    . TRP B 1 197 ? 120.981 103.906 95.261  1.00 47.59  ? 189 TRP B CB    1 
ATOM   5429  C  CG    . TRP B 1 197 ? 119.592 104.416 95.042  1.00 45.64  ? 189 TRP B CG    1 
ATOM   5430  C  CD1   . TRP B 1 197 ? 118.434 103.704 95.124  1.00 48.19  ? 189 TRP B CD1   1 
ATOM   5431  C  CD2   . TRP B 1 197 ? 119.217 105.757 94.715  1.00 43.01  ? 189 TRP B CD2   1 
ATOM   5432  N  NE1   . TRP B 1 197 ? 117.359 104.516 94.862  1.00 48.90  ? 189 TRP B NE1   1 
ATOM   5433  C  CE2   . TRP B 1 197 ? 117.814 105.783 94.609  1.00 44.78  ? 189 TRP B CE2   1 
ATOM   5434  C  CE3   . TRP B 1 197 ? 119.931 106.938 94.499  1.00 42.27  ? 189 TRP B CE3   1 
ATOM   5435  C  CZ2   . TRP B 1 197 ? 117.112 106.942 94.296  1.00 42.64  ? 189 TRP B CZ2   1 
ATOM   5436  C  CZ3   . TRP B 1 197 ? 119.232 108.088 94.189  1.00 41.38  ? 189 TRP B CZ3   1 
ATOM   5437  C  CH2   . TRP B 1 197 ? 117.837 108.082 94.090  1.00 40.40  ? 189 TRP B CH2   1 
ATOM   5438  N  N     . MET B 1 198 ? 121.838 101.032 94.241  1.00 55.76  ? 190 MET B N     1 
ATOM   5439  C  CA    . MET B 1 198 ? 121.772 99.907  93.307  1.00 57.05  ? 190 MET B CA    1 
ATOM   5440  C  C     . MET B 1 198 ? 120.702 100.123 92.237  1.00 57.79  ? 190 MET B C     1 
ATOM   5441  O  O     . MET B 1 198 ? 119.853 99.264  91.993  1.00 60.28  ? 190 MET B O     1 
ATOM   5442  C  CB    . MET B 1 198 ? 121.538 98.590  94.050  1.00 57.45  ? 190 MET B CB    1 
ATOM   5443  C  CG    . MET B 1 198 ? 122.658 98.188  94.983  1.00 61.28  ? 190 MET B CG    1 
ATOM   5444  S  SD    . MET B 1 198 ? 122.269 96.663  95.856  1.00 87.95  ? 190 MET B SD    1 
ATOM   5445  C  CE    . MET B 1 198 ? 123.845 96.308  96.622  1.00 86.93  ? 190 MET B CE    1 
ATOM   5446  N  N     . VAL B 1 199 ? 120.749 101.283 91.590  1.00 57.49  ? 191 VAL B N     1 
ATOM   5447  C  CA    . VAL B 1 199 ? 119.816 101.582 90.507  1.00 65.68  ? 191 VAL B CA    1 
ATOM   5448  C  C     . VAL B 1 199 ? 120.322 100.936 89.224  1.00 70.34  ? 191 VAL B C     1 
ATOM   5449  O  O     . VAL B 1 199 ? 121.450 101.216 88.792  1.00 66.37  ? 191 VAL B O     1 
ATOM   5450  C  CB    . VAL B 1 199 ? 119.629 103.096 90.325  1.00 62.17  ? 191 VAL B CB    1 
ATOM   5451  C  CG1   . VAL B 1 199 ? 118.522 103.367 89.323  1.00 63.18  ? 191 VAL B CG1   1 
ATOM   5452  C  CG2   . VAL B 1 199 ? 119.316 103.753 91.653  1.00 59.91  ? 191 VAL B CG2   1 
ATOM   5453  N  N     . PRO B 1 200 ? 119.537 100.070 88.588  1.00 71.86  ? 192 PRO B N     1 
ATOM   5454  C  CA    . PRO B 1 200 ? 119.989 99.440  87.344  1.00 62.88  ? 192 PRO B CA    1 
ATOM   5455  C  C     . PRO B 1 200 ? 120.153 100.452 86.223  1.00 63.97  ? 192 PRO B C     1 
ATOM   5456  O  O     . PRO B 1 200 ? 119.468 101.476 86.171  1.00 69.27  ? 192 PRO B O     1 
ATOM   5457  C  CB    . PRO B 1 200 ? 118.870 98.442  87.024  1.00 71.11  ? 192 PRO B CB    1 
ATOM   5458  C  CG    . PRO B 1 200 ? 118.158 98.227  88.319  1.00 72.52  ? 192 PRO B CG    1 
ATOM   5459  C  CD    . PRO B 1 200 ? 118.243 99.533  89.041  1.00 73.81  ? 192 PRO B CD    1 
ATOM   5460  N  N     . ALA B 1 201 ? 121.085 100.145 85.319  1.00 66.83  ? 193 ALA B N     1 
ATOM   5461  C  CA    . ALA B 1 201 ? 121.331 100.940 84.115  1.00 64.91  ? 193 ALA B CA    1 
ATOM   5462  C  C     . ALA B 1 201 ? 121.677 102.389 84.441  1.00 61.31  ? 193 ALA B C     1 
ATOM   5463  O  O     . ALA B 1 201 ? 121.345 103.303 83.683  1.00 63.92  ? 193 ALA B O     1 
ATOM   5464  C  CB    . ALA B 1 201 ? 120.138 100.881 83.156  1.00 70.04  ? 193 ALA B CB    1 
ATOM   5465  N  N     . VAL B 1 202 ? 122.345 102.613 85.568  1.00 59.31  ? 194 VAL B N     1 
ATOM   5466  C  CA    . VAL B 1 202 ? 122.811 103.938 85.957  1.00 57.65  ? 194 VAL B CA    1 
ATOM   5467  C  C     . VAL B 1 202 ? 124.290 103.832 86.288  1.00 53.72  ? 194 VAL B C     1 
ATOM   5468  O  O     . VAL B 1 202 ? 124.672 103.089 87.200  1.00 55.26  ? 194 VAL B O     1 
ATOM   5469  C  CB    . VAL B 1 202 ? 122.028 104.504 87.153  1.00 62.05  ? 194 VAL B CB    1 
ATOM   5470  C  CG1   . VAL B 1 202 ? 122.706 105.754 87.682  1.00 58.43  ? 194 VAL B CG1   1 
ATOM   5471  C  CG2   . VAL B 1 202 ? 120.602 104.813 86.746  1.00 63.13  ? 194 VAL B CG2   1 
ATOM   5472  N  N     . ARG B 1 203 ? 125.117 104.566 85.553  1.00 51.59  ? 195 ARG B N     1 
ATOM   5473  C  CA    . ARG B 1 203 ? 126.557 104.577 85.772  1.00 49.94  ? 195 ARG B CA    1 
ATOM   5474  C  C     . ARG B 1 203 ? 126.959 105.958 86.265  1.00 49.49  ? 195 ARG B C     1 
ATOM   5475  O  O     . ARG B 1 203 ? 126.751 106.951 85.565  1.00 57.02  ? 195 ARG B O     1 
ATOM   5476  C  CB    . ARG B 1 203 ? 127.307 104.218 84.490  1.00 50.66  ? 195 ARG B CB    1 
ATOM   5477  C  CG    . ARG B 1 203 ? 128.815 104.182 84.641  1.00 54.31  ? 195 ARG B CG    1 
ATOM   5478  C  CD    . ARG B 1 203 ? 129.482 103.762 83.345  1.00 65.01  ? 195 ARG B CD    1 
ATOM   5479  N  NE    . ARG B 1 203 ? 130.936 103.769 83.452  1.00 66.24  ? 195 ARG B NE    1 
ATOM   5480  C  CZ    . ARG B 1 203 ? 131.761 103.480 82.456  1.00 71.52  ? 195 ARG B CZ    1 
ATOM   5481  N  NH1   . ARG B 1 203 ? 131.308 103.152 81.257  1.00 70.83  ? 195 ARG B NH1   1 
ATOM   5482  N  NH2   . ARG B 1 203 ? 133.073 103.521 82.667  1.00 78.04  ? 195 ARG B NH2   1 
ATOM   5483  N  N     . VAL B 1 204 ? 127.549 106.020 87.455  1.00 48.10  ? 196 VAL B N     1 
ATOM   5484  C  CA    . VAL B 1 204 ? 127.861 107.282 88.113  1.00 44.53  ? 196 VAL B CA    1 
ATOM   5485  C  C     . VAL B 1 204 ? 129.371 107.424 88.212  1.00 47.87  ? 196 VAL B C     1 
ATOM   5486  O  O     . VAL B 1 204 ? 130.057 106.506 88.674  1.00 55.46  ? 196 VAL B O     1 
ATOM   5487  C  CB    . VAL B 1 204 ? 127.217 107.369 89.508  1.00 47.52  ? 196 VAL B CB    1 
ATOM   5488  C  CG1   . VAL B 1 204 ? 127.488 108.725 90.131  1.00 49.01  ? 196 VAL B CG1   1 
ATOM   5489  C  CG2   . VAL B 1 204 ? 125.725 107.104 89.421  1.00 50.59  ? 196 VAL B CG2   1 
ATOM   5490  N  N     . ASP B 1 205 ? 129.885 108.573 87.780  1.00 45.87  ? 197 ASP B N     1 
ATOM   5491  C  CA    . ASP B 1 205 ? 131.297 108.895 87.903  1.00 47.22  ? 197 ASP B CA    1 
ATOM   5492  C  C     . ASP B 1 205 ? 131.439 110.240 88.597  1.00 47.91  ? 197 ASP B C     1 
ATOM   5493  O  O     . ASP B 1 205 ? 130.557 111.097 88.504  1.00 51.98  ? 197 ASP B O     1 
ATOM   5494  C  CB    . ASP B 1 205 ? 131.993 108.928 86.537  1.00 49.92  ? 197 ASP B CB    1 
ATOM   5495  C  CG    . ASP B 1 205 ? 132.025 107.569 85.867  1.00 56.70  ? 197 ASP B CG    1 
ATOM   5496  O  OD1   . ASP B 1 205 ? 132.054 106.549 86.587  1.00 53.68  ? 197 ASP B OD1   1 
ATOM   5497  O  OD2   . ASP B 1 205 ? 132.023 107.519 84.620  1.00 65.05  ? 197 ASP B OD2   1 
ATOM   5498  N  N     . PHE B 1 206 ? 132.554 110.415 89.300  1.00 47.91  ? 198 PHE B N     1 
ATOM   5499  C  CA    . PHE B 1 206 ? 132.783 111.588 90.126  1.00 48.44  ? 198 PHE B CA    1 
ATOM   5500  C  C     . PHE B 1 206 ? 134.036 112.321 89.670  1.00 49.59  ? 198 PHE B C     1 
ATOM   5501  O  O     . PHE B 1 206 ? 135.001 111.709 89.205  1.00 52.35  ? 198 PHE B O     1 
ATOM   5502  C  CB    . PHE B 1 206 ? 132.913 111.203 91.603  1.00 49.94  ? 198 PHE B CB    1 
ATOM   5503  C  CG    . PHE B 1 206 ? 131.676 110.575 92.172  1.00 50.36  ? 198 PHE B CG    1 
ATOM   5504  C  CD1   . PHE B 1 206 ? 131.449 109.217 92.040  1.00 49.48  ? 198 PHE B CD1   1 
ATOM   5505  C  CD2   . PHE B 1 206 ? 130.736 111.344 92.831  1.00 49.67  ? 198 PHE B CD2   1 
ATOM   5506  C  CE1   . PHE B 1 206 ? 130.310 108.640 92.557  1.00 49.19  ? 198 PHE B CE1   1 
ATOM   5507  C  CE2   . PHE B 1 206 ? 129.598 110.771 93.349  1.00 47.80  ? 198 PHE B CE2   1 
ATOM   5508  C  CZ    . PHE B 1 206 ? 129.384 109.418 93.211  1.00 46.96  ? 198 PHE B CZ    1 
ATOM   5509  N  N     . TYR B 1 207 ? 134.007 113.643 89.804  1.00 50.98  ? 199 TYR B N     1 
ATOM   5510  C  CA    . TYR B 1 207 ? 135.108 114.497 89.390  1.00 57.70  ? 199 TYR B CA    1 
ATOM   5511  C  C     . TYR B 1 207 ? 135.421 115.501 90.488  1.00 66.91  ? 199 TYR B C     1 
ATOM   5512  O  O     . TYR B 1 207 ? 134.515 116.106 91.071  1.00 70.89  ? 199 TYR B O     1 
ATOM   5513  C  CB    . TYR B 1 207 ? 134.782 115.222 88.079  1.00 57.78  ? 199 TYR B CB    1 
ATOM   5514  C  CG    . TYR B 1 207 ? 134.480 114.278 86.938  1.00 54.86  ? 199 TYR B CG    1 
ATOM   5515  C  CD1   . TYR B 1 207 ? 133.188 113.826 86.711  1.00 55.57  ? 199 TYR B CD1   1 
ATOM   5516  C  CD2   . TYR B 1 207 ? 135.487 113.829 86.098  1.00 52.91  ? 199 TYR B CD2   1 
ATOM   5517  C  CE1   . TYR B 1 207 ? 132.907 112.959 85.676  1.00 52.43  ? 199 TYR B CE1   1 
ATOM   5518  C  CE2   . TYR B 1 207 ? 135.215 112.962 85.060  1.00 56.97  ? 199 TYR B CE2   1 
ATOM   5519  C  CZ    . TYR B 1 207 ? 133.923 112.530 84.854  1.00 55.55  ? 199 TYR B CZ    1 
ATOM   5520  O  OH    . TYR B 1 207 ? 133.643 111.666 83.823  1.00 59.51  ? 199 TYR B OH    1 
ATOM   5521  N  N     . ASN B 1 208 ? 136.711 115.674 90.763  1.00 71.47  ? 200 ASN B N     1 
ATOM   5522  C  CA    . ASN B 1 208 ? 137.160 116.565 91.827  1.00 81.26  ? 200 ASN B CA    1 
ATOM   5523  C  C     . ASN B 1 208 ? 136.835 118.005 91.452  1.00 84.85  ? 200 ASN B C     1 
ATOM   5524  O  O     . ASN B 1 208 ? 137.408 118.556 90.507  1.00 89.68  ? 200 ASN B O     1 
ATOM   5525  C  CB    . ASN B 1 208 ? 138.657 116.384 92.063  1.00 86.73  ? 200 ASN B CB    1 
ATOM   5526  C  CG    . ASN B 1 208 ? 139.135 117.048 93.342  1.00 96.21  ? 200 ASN B CG    1 
ATOM   5527  O  OD1   . ASN B 1 208 ? 138.560 118.033 93.802  1.00 98.33  ? 200 ASN B OD1   1 
ATOM   5528  N  ND2   . ASN B 1 208 ? 140.199 116.506 93.923  1.00 100.17 ? 200 ASN B ND2   1 
ATOM   5529  N  N     . ALA B 1 209 ? 135.913 118.619 92.196  1.00 83.34  ? 201 ALA B N     1 
ATOM   5530  C  CA    . ALA B 1 209 ? 135.560 120.009 91.940  1.00 87.12  ? 201 ALA B CA    1 
ATOM   5531  C  C     . ALA B 1 209 ? 136.634 120.969 92.432  1.00 100.94 ? 201 ALA B C     1 
ATOM   5532  O  O     . ALA B 1 209 ? 136.782 122.064 91.878  1.00 105.86 ? 201 ALA B O     1 
ATOM   5533  C  CB    . ALA B 1 209 ? 134.218 120.340 92.592  1.00 81.20  ? 201 ALA B CB    1 
ATOM   5534  N  N     . ASP B 1 210 ? 137.385 120.584 93.466  1.00 101.09 ? 202 ASP B N     1 
ATOM   5535  C  CA    . ASP B 1 210 ? 138.401 121.475 94.017  1.00 104.79 ? 202 ASP B CA    1 
ATOM   5536  C  C     . ASP B 1 210 ? 139.494 121.768 92.997  1.00 109.65 ? 202 ASP B C     1 
ATOM   5537  O  O     . ASP B 1 210 ? 139.986 122.900 92.912  1.00 115.27 ? 202 ASP B O     1 
ATOM   5538  C  CB    . ASP B 1 210 ? 138.998 120.868 95.287  1.00 107.32 ? 202 ASP B CB    1 
ATOM   5539  C  CG    . ASP B 1 210 ? 137.943 120.528 96.321  1.00 109.28 ? 202 ASP B CG    1 
ATOM   5540  O  OD1   . ASP B 1 210 ? 136.874 121.173 96.315  1.00 106.68 ? 202 ASP B OD1   1 
ATOM   5541  O  OD2   . ASP B 1 210 ? 138.182 119.616 97.140  1.00 107.22 ? 202 ASP B OD2   1 
ATOM   5542  N  N     . GLU B 1 211 ? 139.885 120.760 92.211  1.00 107.56 ? 203 GLU B N     1 
ATOM   5543  C  CA    . GLU B 1 211 ? 140.925 120.959 91.206  1.00 109.90 ? 203 GLU B CA    1 
ATOM   5544  C  C     . GLU B 1 211 ? 140.522 122.008 90.178  1.00 112.13 ? 203 GLU B C     1 
ATOM   5545  O  O     . GLU B 1 211 ? 141.389 122.644 89.568  1.00 114.98 ? 203 GLU B O     1 
ATOM   5546  C  CB    . GLU B 1 211 ? 141.243 119.635 90.512  1.00 107.24 ? 203 GLU B CB    1 
ATOM   5547  C  CG    . GLU B 1 211 ? 141.702 118.534 91.453  1.00 108.23 ? 203 GLU B CG    1 
ATOM   5548  C  CD    . GLU B 1 211 ? 141.891 117.206 90.746  1.00 110.70 ? 203 GLU B CD    1 
ATOM   5549  O  OE1   . GLU B 1 211 ? 141.703 117.156 89.512  1.00 112.97 ? 203 GLU B OE1   1 
ATOM   5550  O  OE2   . GLU B 1 211 ? 142.224 116.212 91.425  1.00 107.84 ? 203 GLU B OE2   1 
ATOM   5551  N  N     . LEU B 1 212 ? 139.222 122.203 89.972  1.00 111.12 ? 204 LEU B N     1 
ATOM   5552  C  CA    . LEU B 1 212 ? 138.728 123.204 89.039  1.00 110.75 ? 204 LEU B CA    1 
ATOM   5553  C  C     . LEU B 1 212 ? 138.627 124.593 89.651  1.00 116.29 ? 204 LEU B C     1 
ATOM   5554  O  O     . LEU B 1 212 ? 138.384 125.557 88.916  1.00 123.08 ? 204 LEU B O     1 
ATOM   5555  C  CB    . LEU B 1 212 ? 137.355 122.790 88.502  1.00 104.43 ? 204 LEU B CB    1 
ATOM   5556  C  CG    . LEU B 1 212 ? 137.266 121.375 87.934  1.00 98.14  ? 204 LEU B CG    1 
ATOM   5557  C  CD1   . LEU B 1 212 ? 135.865 121.095 87.418  1.00 92.77  ? 204 LEU B CD1   1 
ATOM   5558  C  CD2   . LEU B 1 212 ? 138.300 121.174 86.839  1.00 98.42  ? 204 LEU B CD2   1 
ATOM   5559  N  N     . LYS B 1 213 ? 138.811 124.721 90.968  1.00 115.82 ? 205 LYS B N     1 
ATOM   5560  C  CA    . LYS B 1 213 ? 138.672 126.024 91.610  1.00 121.47 ? 205 LYS B CA    1 
ATOM   5561  C  C     . LYS B 1 213 ? 139.684 127.021 91.061  1.00 130.24 ? 205 LYS B C     1 
ATOM   5562  O  O     . LYS B 1 213 ? 139.339 128.176 90.782  1.00 134.20 ? 205 LYS B O     1 
ATOM   5563  C  CB    . LYS B 1 213 ? 138.822 125.885 93.125  1.00 118.64 ? 205 LYS B CB    1 
ATOM   5564  C  CG    . LYS B 1 213 ? 137.682 125.138 93.793  1.00 116.95 ? 205 LYS B CG    1 
ATOM   5565  C  CD    . LYS B 1 213 ? 137.835 125.135 95.305  1.00 115.55 ? 205 LYS B CD    1 
ATOM   5566  C  CE    . LYS B 1 213 ? 136.655 124.451 95.976  1.00 111.96 ? 205 LYS B CE    1 
ATOM   5567  N  NZ    . LYS B 1 213 ? 136.771 124.464 97.460  1.00 116.31 ? 205 LYS B NZ    1 
ATOM   5568  N  N     . SER B 1 214 ? 140.934 126.589 90.881  1.00 131.01 ? 206 SER B N     1 
ATOM   5569  C  CA    . SER B 1 214 ? 141.947 127.463 90.302  1.00 134.69 ? 206 SER B CA    1 
ATOM   5570  C  C     . SER B 1 214 ? 141.587 127.899 88.889  1.00 132.14 ? 206 SER B C     1 
ATOM   5571  O  O     . SER B 1 214 ? 142.102 128.917 88.415  1.00 132.20 ? 206 SER B O     1 
ATOM   5572  C  CB    . SER B 1 214 ? 143.308 126.764 90.302  1.00 133.84 ? 206 SER B CB    1 
ATOM   5573  O  OG    . SER B 1 214 ? 143.270 125.574 89.534  1.00 130.01 ? 206 SER B OG    1 
ATOM   5574  N  N     . GLU B 1 215 ? 140.715 127.153 88.206  1.00 129.87 ? 207 GLU B N     1 
ATOM   5575  C  CA    . GLU B 1 215 ? 140.271 127.558 86.879  1.00 127.55 ? 207 GLU B CA    1 
ATOM   5576  C  C     . GLU B 1 215 ? 139.320 128.745 86.927  1.00 131.47 ? 207 GLU B C     1 
ATOM   5577  O  O     . GLU B 1 215 ? 139.183 129.451 85.922  1.00 135.07 ? 207 GLU B O     1 
ATOM   5578  C  CB    . GLU B 1 215 ? 139.598 126.383 86.168  1.00 121.58 ? 207 GLU B CB    1 
ATOM   5579  C  CG    . GLU B 1 215 ? 140.422 125.106 86.167  1.00 124.43 ? 207 GLU B CG    1 
ATOM   5580  C  CD    . GLU B 1 215 ? 141.733 125.254 85.421  1.00 130.63 ? 207 GLU B CD    1 
ATOM   5581  O  OE1   . GLU B 1 215 ? 141.799 126.074 84.481  1.00 132.53 ? 207 GLU B OE1   1 
ATOM   5582  O  OE2   . GLU B 1 215 ? 142.701 124.549 85.775  1.00 130.67 ? 207 GLU B OE2   1 
ATOM   5583  N  N     . VAL B 1 216 ? 138.662 128.980 88.061  1.00 131.64 ? 208 VAL B N     1 
ATOM   5584  C  CA    . VAL B 1 216 ? 137.709 130.077 88.179  1.00 133.52 ? 208 VAL B CA    1 
ATOM   5585  C  C     . VAL B 1 216 ? 138.011 130.894 89.427  1.00 138.20 ? 208 VAL B C     1 
ATOM   5586  O  O     . VAL B 1 216 ? 137.186 131.702 89.868  1.00 141.62 ? 208 VAL B O     1 
ATOM   5587  C  CB    . VAL B 1 216 ? 136.261 129.557 88.201  1.00 128.42 ? 208 VAL B CB    1 
ATOM   5588  C  CG1   . VAL B 1 216 ? 135.885 128.976 86.849  1.00 125.84 ? 208 VAL B CG1   1 
ATOM   5589  C  CG2   . VAL B 1 216 ? 136.095 128.517 89.293  1.00 124.86 ? 208 VAL B CG2   1 
ATOM   5590  N  N     . SER B 1 217 ? 139.197 130.691 90.006  1.00 138.08 ? 209 SER B N     1 
ATOM   5591  C  CA    . SER B 1 217 ? 139.579 131.454 91.189  1.00 139.99 ? 209 SER B CA    1 
ATOM   5592  C  C     . SER B 1 217 ? 139.778 132.930 90.869  1.00 146.05 ? 209 SER B C     1 
ATOM   5593  O  O     . SER B 1 217 ? 139.701 133.774 91.769  1.00 146.24 ? 209 SER B O     1 
ATOM   5594  C  CB    . SER B 1 217 ? 140.850 130.871 91.806  1.00 136.34 ? 209 SER B CB    1 
ATOM   5595  O  OG    . SER B 1 217 ? 141.928 130.912 90.887  1.00 135.37 ? 209 SER B OG    1 
ATOM   5596  N  N     . TRP B 1 218 ? 140.034 133.258 89.603  1.00 147.63 ? 210 TRP B N     1 
ATOM   5597  C  CA    . TRP B 1 218 ? 140.252 134.639 89.193  1.00 148.28 ? 210 TRP B CA    1 
ATOM   5598  C  C     . TRP B 1 218 ? 138.958 135.393 88.913  1.00 147.84 ? 210 TRP B C     1 
ATOM   5599  O  O     . TRP B 1 218 ? 139.012 136.596 88.640  1.00 148.55 ? 210 TRP B O     1 
ATOM   5600  C  CB    . TRP B 1 218 ? 141.148 134.677 87.952  1.00 146.31 ? 210 TRP B CB    1 
ATOM   5601  C  CG    . TRP B 1 218 ? 140.623 133.860 86.811  1.00 144.58 ? 210 TRP B CG    1 
ATOM   5602  C  CD1   . TRP B 1 218 ? 140.773 132.517 86.627  1.00 142.64 ? 210 TRP B CD1   1 
ATOM   5603  C  CD2   . TRP B 1 218 ? 139.867 134.336 85.691  1.00 144.83 ? 210 TRP B CD2   1 
ATOM   5604  N  NE1   . TRP B 1 218 ? 140.154 132.125 85.465  1.00 141.18 ? 210 TRP B NE1   1 
ATOM   5605  C  CE2   . TRP B 1 218 ? 139.590 133.224 84.871  1.00 142.51 ? 210 TRP B CE2   1 
ATOM   5606  C  CE3   . TRP B 1 218 ? 139.396 135.594 85.303  1.00 145.57 ? 210 TRP B CE3   1 
ATOM   5607  C  CZ2   . TRP B 1 218 ? 138.865 133.331 83.687  1.00 140.83 ? 210 TRP B CZ2   1 
ATOM   5608  C  CZ3   . TRP B 1 218 ? 138.675 135.698 84.128  1.00 145.03 ? 210 TRP B CZ3   1 
ATOM   5609  C  CH2   . TRP B 1 218 ? 138.416 134.574 83.334  1.00 142.57 ? 210 TRP B CH2   1 
ATOM   5610  N  N     . ILE B 1 219 ? 137.809 134.727 88.974  1.00 147.02 ? 211 ILE B N     1 
ATOM   5611  C  CA    . ILE B 1 219 ? 136.520 135.348 88.681  1.00 147.86 ? 211 ILE B CA    1 
ATOM   5612  C  C     . ILE B 1 219 ? 135.804 135.586 90.009  1.00 152.05 ? 211 ILE B C     1 
ATOM   5613  O  O     . ILE B 1 219 ? 135.372 134.612 90.648  1.00 150.67 ? 211 ILE B O     1 
ATOM   5614  C  CB    . ILE B 1 219 ? 135.672 134.475 87.748  1.00 143.81 ? 211 ILE B CB    1 
ATOM   5615  C  CG1   . ILE B 1 219 ? 136.489 134.044 86.530  1.00 144.06 ? 211 ILE B CG1   1 
ATOM   5616  C  CG2   . ILE B 1 219 ? 134.422 135.224 87.314  1.00 140.59 ? 211 ILE B CG2   1 
ATOM   5617  C  CD1   . ILE B 1 219 ? 135.736 133.137 85.582  1.00 140.96 ? 211 ILE B CD1   1 
ATOM   5618  N  N     . PRO B 1 220 ? 135.664 136.831 90.462  1.00 154.02 ? 212 PRO B N     1 
ATOM   5619  C  CA    . PRO B 1 220 ? 134.854 137.088 91.659  1.00 151.48 ? 212 PRO B CA    1 
ATOM   5620  C  C     . PRO B 1 220 ? 133.404 136.687 91.432  1.00 147.27 ? 212 PRO B C     1 
ATOM   5621  O  O     . PRO B 1 220 ? 132.857 136.858 90.341  1.00 145.80 ? 212 PRO B O     1 
ATOM   5622  C  CB    . PRO B 1 220 ? 134.997 138.601 91.867  1.00 152.85 ? 212 PRO B CB    1 
ATOM   5623  C  CG    . PRO B 1 220 ? 136.254 138.969 91.147  1.00 152.93 ? 212 PRO B CG    1 
ATOM   5624  C  CD    . PRO B 1 220 ? 136.321 138.050 89.965  1.00 151.06 ? 212 PRO B CD    1 
ATOM   5625  N  N     . ASN B 1 221 ? 132.782 136.148 92.478  1.00 143.86 ? 213 ASN B N     1 
ATOM   5626  C  CA    . ASN B 1 221 ? 131.407 135.679 92.393  1.00 141.12 ? 213 ASN B CA    1 
ATOM   5627  C  C     . ASN B 1 221 ? 130.641 136.097 93.638  1.00 139.90 ? 213 ASN B C     1 
ATOM   5628  O  O     . ASN B 1 221 ? 131.203 136.149 94.735  1.00 140.22 ? 213 ASN B O     1 
ATOM   5629  C  CB    . ASN B 1 221 ? 131.348 134.155 92.225  1.00 136.87 ? 213 ASN B CB    1 
ATOM   5630  C  CG    . ASN B 1 221 ? 129.949 133.655 91.925  1.00 134.79 ? 213 ASN B CG    1 
ATOM   5631  O  OD1   . ASN B 1 221 ? 129.075 134.424 91.526  1.00 137.38 ? 213 ASN B OD1   1 
ATOM   5632  N  ND2   . ASN B 1 221 ? 129.730 132.359 92.115  1.00 130.38 ? 213 ASN B ND2   1 
ATOM   5633  N  N     . LYS B 1 222 ? 129.353 136.395 93.458  1.00 138.45 ? 214 LYS B N     1 
ATOM   5634  C  CA    . LYS B 1 222 ? 128.473 136.761 94.557  1.00 135.60 ? 214 LYS B CA    1 
ATOM   5635  C  C     . LYS B 1 222 ? 127.222 135.899 94.650  1.00 131.53 ? 214 LYS B C     1 
ATOM   5636  O  O     . LYS B 1 222 ? 126.449 136.066 95.600  1.00 126.41 ? 214 LYS B O     1 
ATOM   5637  C  CB    . LYS B 1 222 ? 128.058 138.237 94.445  1.00 139.21 ? 214 LYS B CB    1 
ATOM   5638  C  CG    . LYS B 1 222 ? 129.225 139.210 94.488  1.00 141.22 ? 214 LYS B CG    1 
ATOM   5639  C  CD    . LYS B 1 222 ? 128.758 140.647 94.328  1.00 143.80 ? 214 LYS B CD    1 
ATOM   5640  C  CE    . LYS B 1 222 ? 129.931 141.613 94.354  1.00 145.92 ? 214 LYS B CE    1 
ATOM   5641  N  NZ    . LYS B 1 222 ? 129.492 143.027 94.197  1.00 142.33 ? 214 LYS B NZ    1 
ATOM   5642  N  N     . HIS B 1 223 ? 126.997 134.997 93.699  1.00 130.69 ? 215 HIS B N     1 
ATOM   5643  C  CA    . HIS B 1 223 ? 125.861 134.090 93.764  1.00 124.12 ? 215 HIS B CA    1 
ATOM   5644  C  C     . HIS B 1 223 ? 126.007 133.147 94.953  1.00 126.09 ? 215 HIS B C     1 
ATOM   5645  O  O     . HIS B 1 223 ? 127.116 132.766 95.339  1.00 126.91 ? 215 HIS B O     1 
ATOM   5646  C  CB    . HIS B 1 223 ? 125.747 133.296 92.463  1.00 118.88 ? 215 HIS B CB    1 
ATOM   5647  C  CG    . HIS B 1 223 ? 124.471 132.524 92.328  1.00 112.46 ? 215 HIS B CG    1 
ATOM   5648  N  ND1   . HIS B 1 223 ? 124.383 131.176 92.600  1.00 112.97 ? 215 HIS B ND1   1 
ATOM   5649  C  CD2   . HIS B 1 223 ? 123.234 132.909 91.934  1.00 109.58 ? 215 HIS B CD2   1 
ATOM   5650  C  CE1   . HIS B 1 223 ? 123.147 130.765 92.386  1.00 109.55 ? 215 HIS B CE1   1 
ATOM   5651  N  NE2   . HIS B 1 223 ? 122.429 131.797 91.982  1.00 105.49 ? 215 HIS B NE2   1 
ATOM   5652  N  N     . TYR B 1 224 ? 124.868 132.771 95.542  1.00 125.47 ? 216 TYR B N     1 
ATOM   5653  C  CA    . TYR B 1 224 ? 124.897 131.959 96.754  1.00 122.98 ? 216 TYR B CA    1 
ATOM   5654  C  C     . TYR B 1 224 ? 125.493 130.577 96.517  1.00 121.92 ? 216 TYR B C     1 
ATOM   5655  O  O     . TYR B 1 224 ? 125.922 129.931 97.479  1.00 122.17 ? 216 TYR B O     1 
ATOM   5656  C  CB    . TYR B 1 224 ? 123.490 131.831 97.346  1.00 122.71 ? 216 TYR B CB    1 
ATOM   5657  C  CG    . TYR B 1 224 ? 122.541 130.956 96.557  1.00 121.02 ? 216 TYR B CG    1 
ATOM   5658  C  CD1   . TYR B 1 224 ? 121.747 131.490 95.551  1.00 122.13 ? 216 TYR B CD1   1 
ATOM   5659  C  CD2   . TYR B 1 224 ? 122.424 129.599 96.833  1.00 118.42 ? 216 TYR B CD2   1 
ATOM   5660  C  CE1   . TYR B 1 224 ? 120.873 130.695 94.834  1.00 123.05 ? 216 TYR B CE1   1 
ATOM   5661  C  CE2   . TYR B 1 224 ? 121.556 128.797 96.120  1.00 119.76 ? 216 TYR B CE2   1 
ATOM   5662  C  CZ    . TYR B 1 224 ? 120.782 129.349 95.123  1.00 122.14 ? 216 TYR B CZ    1 
ATOM   5663  O  OH    . TYR B 1 224 ? 119.914 128.553 94.412  1.00 117.64 ? 216 TYR B OH    1 
ATOM   5664  N  N     . SER B 1 225 ? 125.530 130.109 95.268  1.00 121.53 ? 217 SER B N     1 
ATOM   5665  C  CA    . SER B 1 225 ? 126.191 128.846 94.966  1.00 120.20 ? 217 SER B CA    1 
ATOM   5666  C  C     . SER B 1 225 ? 127.706 128.935 95.091  1.00 122.55 ? 217 SER B C     1 
ATOM   5667  O  O     . SER B 1 225 ? 128.371 127.894 95.098  1.00 125.59 ? 217 SER B O     1 
ATOM   5668  C  CB    . SER B 1 225 ? 125.815 128.374 93.560  1.00 114.27 ? 217 SER B CB    1 
ATOM   5669  O  OG    . SER B 1 225 ? 126.187 129.331 92.585  1.00 116.10 ? 217 SER B OG    1 
ATOM   5670  N  N     . GLY B 1 226 ? 128.262 130.141 95.187  1.00 120.58 ? 218 GLY B N     1 
ATOM   5671  C  CA    . GLY B 1 226 ? 129.684 130.296 95.401  1.00 121.66 ? 218 GLY B CA    1 
ATOM   5672  C  C     . GLY B 1 226 ? 130.512 129.974 94.165  1.00 123.45 ? 218 GLY B C     1 
ATOM   5673  O  O     . GLY B 1 226 ? 130.027 129.951 93.030  1.00 125.89 ? 218 GLY B O     1 
ATOM   5674  N  N     . ILE B 1 227 ? 131.798 129.715 94.417  1.00 120.89 ? 219 ILE B N     1 
ATOM   5675  C  CA    . ILE B 1 227 ? 132.736 129.422 93.337  1.00 122.69 ? 219 ILE B CA    1 
ATOM   5676  C  C     . ILE B 1 227 ? 132.311 128.176 92.572  1.00 119.77 ? 219 ILE B C     1 
ATOM   5677  O  O     . ILE B 1 227 ? 132.553 128.065 91.363  1.00 117.15 ? 219 ILE B O     1 
ATOM   5678  C  CB    . ILE B 1 227 ? 134.164 129.292 93.906  1.00 123.31 ? 219 ILE B CB    1 
ATOM   5679  C  CG1   . ILE B 1 227 ? 135.166 128.957 92.800  1.00 123.51 ? 219 ILE B CG1   1 
ATOM   5680  C  CG2   . ILE B 1 227 ? 134.210 128.251 95.015  1.00 120.35 ? 219 ILE B CG2   1 
ATOM   5681  C  CD1   . ILE B 1 227 ? 136.590 128.826 93.290  1.00 121.82 ? 219 ILE B CD1   1 
ATOM   5682  N  N     . TYR B 1 228 ? 131.645 127.235 93.248  1.00 117.67 ? 220 TYR B N     1 
ATOM   5683  C  CA    . TYR B 1 228 ? 131.170 126.029 92.579  1.00 114.30 ? 220 TYR B CA    1 
ATOM   5684  C  C     . TYR B 1 228 ? 130.176 126.339 91.470  1.00 110.46 ? 220 TYR B C     1 
ATOM   5685  O  O     . TYR B 1 228 ? 129.962 125.497 90.591  1.00 106.36 ? 220 TYR B O     1 
ATOM   5686  C  CB    . TYR B 1 228 ? 130.531 125.078 93.592  1.00 108.53 ? 220 TYR B CB    1 
ATOM   5687  C  CG    . TYR B 1 228 ? 131.481 124.576 94.654  1.00 107.62 ? 220 TYR B CG    1 
ATOM   5688  C  CD1   . TYR B 1 228 ? 132.271 123.456 94.433  1.00 103.20 ? 220 TYR B CD1   1 
ATOM   5689  C  CD2   . TYR B 1 228 ? 131.582 125.216 95.881  1.00 109.10 ? 220 TYR B CD2   1 
ATOM   5690  C  CE1   . TYR B 1 228 ? 133.138 122.990 95.402  1.00 99.94  ? 220 TYR B CE1   1 
ATOM   5691  C  CE2   . TYR B 1 228 ? 132.446 124.759 96.857  1.00 108.18 ? 220 TYR B CE2   1 
ATOM   5692  C  CZ    . TYR B 1 228 ? 133.221 123.645 96.612  1.00 104.29 ? 220 TYR B CZ    1 
ATOM   5693  O  OH    . TYR B 1 228 ? 134.083 123.186 97.581  1.00 103.75 ? 220 TYR B OH    1 
ATOM   5694  N  N     . GLY B 1 229 ? 129.562 127.521 91.489  1.00 112.77 ? 221 GLY B N     1 
ATOM   5695  C  CA    . GLY B 1 229 ? 128.676 127.908 90.411  1.00 114.27 ? 221 GLY B CA    1 
ATOM   5696  C  C     . GLY B 1 229 ? 129.368 128.322 89.132  1.00 117.04 ? 221 GLY B C     1 
ATOM   5697  O  O     . GLY B 1 229 ? 128.708 128.430 88.096  1.00 115.28 ? 221 GLY B O     1 
ATOM   5698  N  N     . LEU B 1 230 ? 130.679 128.551 89.178  1.00 119.19 ? 222 LEU B N     1 
ATOM   5699  C  CA    . LEU B 1 230 ? 131.439 128.970 88.009  1.00 115.67 ? 222 LEU B CA    1 
ATOM   5700  C  C     . LEU B 1 230 ? 132.068 127.806 87.255  1.00 111.15 ? 222 LEU B C     1 
ATOM   5701  O  O     . LEU B 1 230 ? 132.780 128.037 86.273  1.00 112.24 ? 222 LEU B O     1 
ATOM   5702  C  CB    . LEU B 1 230 ? 132.536 129.957 88.422  1.00 120.80 ? 222 LEU B CB    1 
ATOM   5703  C  CG    . LEU B 1 230 ? 132.092 131.266 89.078  1.00 124.70 ? 222 LEU B CG    1 
ATOM   5704  C  CD1   . LEU B 1 230 ? 133.289 132.015 89.640  1.00 133.06 ? 222 LEU B CD1   1 
ATOM   5705  C  CD2   . LEU B 1 230 ? 131.346 132.131 88.082  1.00 121.81 ? 222 LEU B CD2   1 
ATOM   5706  N  N     . MET B 1 231 ? 131.825 126.569 87.684  1.00 110.15 ? 223 MET B N     1 
ATOM   5707  C  CA    . MET B 1 231 ? 132.516 125.418 87.118  1.00 107.24 ? 223 MET B CA    1 
ATOM   5708  C  C     . MET B 1 231 ? 131.854 124.861 85.865  1.00 103.29 ? 223 MET B C     1 
ATOM   5709  O  O     . MET B 1 231 ? 132.519 124.154 85.098  1.00 102.50 ? 223 MET B O     1 
ATOM   5710  C  CB    . MET B 1 231 ? 132.630 124.312 88.171  1.00 105.25 ? 223 MET B CB    1 
ATOM   5711  C  CG    . MET B 1 231 ? 133.379 124.751 89.416  1.00 111.88 ? 223 MET B CG    1 
ATOM   5712  S  SD    . MET B 1 231 ? 133.566 123.458 90.653  1.00 115.17 ? 223 MET B SD    1 
ATOM   5713  C  CE    . MET B 1 231 ? 134.517 124.338 91.889  1.00 114.54 ? 223 MET B CE    1 
ATOM   5714  N  N     . LYS B 1 232 ? 130.578 125.174 85.623  1.00 98.72  ? 224 LYS B N     1 
ATOM   5715  C  CA    . LYS B 1 232 ? 129.909 124.652 84.436  1.00 93.73  ? 224 LYS B CA    1 
ATOM   5716  C  C     . LYS B 1 232 ? 130.571 125.123 83.149  1.00 101.64 ? 224 LYS B C     1 
ATOM   5717  O  O     . LYS B 1 232 ? 130.354 124.516 82.095  1.00 103.24 ? 224 LYS B O     1 
ATOM   5718  C  CB    . LYS B 1 232 ? 128.432 125.046 84.440  1.00 89.70  ? 224 LYS B CB    1 
ATOM   5719  C  CG    . LYS B 1 232 ? 127.574 124.201 85.363  1.00 82.34  ? 224 LYS B CG    1 
ATOM   5720  C  CD    . LYS B 1 232 ? 126.106 124.566 85.248  1.00 76.79  ? 224 LYS B CD    1 
ATOM   5721  C  CE    . LYS B 1 232 ? 125.849 125.981 85.732  1.00 85.67  ? 224 LYS B CE    1 
ATOM   5722  N  NZ    . LYS B 1 232 ? 124.401 126.321 85.687  1.00 79.84  ? 224 LYS B NZ    1 
ATOM   5723  N  N     . LEU B 1 233 ? 131.369 126.190 83.211  1.00 104.55 ? 225 LEU B N     1 
ATOM   5724  C  CA    . LEU B 1 233 ? 132.109 126.635 82.036  1.00 102.48 ? 225 LEU B CA    1 
ATOM   5725  C  C     . LEU B 1 233 ? 133.203 125.644 81.656  1.00 101.95 ? 225 LEU B C     1 
ATOM   5726  O  O     . LEU B 1 233 ? 133.461 125.425 80.467  1.00 105.19 ? 225 LEU B O     1 
ATOM   5727  C  CB    . LEU B 1 233 ? 132.708 128.017 82.291  1.00 109.53 ? 225 LEU B CB    1 
ATOM   5728  C  CG    . LEU B 1 233 ? 131.728 129.166 82.526  1.00 113.60 ? 225 LEU B CG    1 
ATOM   5729  C  CD1   . LEU B 1 233 ? 132.448 130.368 83.110  1.00 117.67 ? 225 LEU B CD1   1 
ATOM   5730  C  CD2   . LEU B 1 233 ? 131.034 129.540 81.229  1.00 114.40 ? 225 LEU B CD2   1 
ATOM   5731  N  N     . VAL B 1 234 ? 133.855 125.035 82.644  1.00 101.09 ? 226 VAL B N     1 
ATOM   5732  C  CA    . VAL B 1 234 ? 135.054 124.241 82.400  1.00 100.06 ? 226 VAL B CA    1 
ATOM   5733  C  C     . VAL B 1 234 ? 134.736 122.748 82.301  1.00 95.91  ? 226 VAL B C     1 
ATOM   5734  O  O     . VAL B 1 234 ? 135.645 121.919 82.362  1.00 96.07  ? 226 VAL B O     1 
ATOM   5735  C  CB    . VAL B 1 234 ? 136.132 124.510 83.461  1.00 98.75  ? 226 VAL B CB    1 
ATOM   5736  C  CG1   . VAL B 1 234 ? 136.457 125.994 83.522  1.00 105.30 ? 226 VAL B CG1   1 
ATOM   5737  C  CG2   . VAL B 1 234 ? 135.684 124.003 84.819  1.00 97.17  ? 226 VAL B CG2   1 
ATOM   5738  N  N     . LEU B 1 235 ? 133.462 122.390 82.127  1.00 93.87  ? 227 LEU B N     1 
ATOM   5739  C  CA    . LEU B 1 235 ? 133.094 120.979 82.057  1.00 91.49  ? 227 LEU B CA    1 
ATOM   5740  C  C     . LEU B 1 235 ? 133.775 120.286 80.884  1.00 93.54  ? 227 LEU B C     1 
ATOM   5741  O  O     . LEU B 1 235 ? 134.177 119.121 80.991  1.00 94.78  ? 227 LEU B O     1 
ATOM   5742  C  CB    . LEU B 1 235 ? 131.578 120.833 81.958  1.00 86.61  ? 227 LEU B CB    1 
ATOM   5743  C  CG    . LEU B 1 235 ? 130.789 121.411 83.132  1.00 92.73  ? 227 LEU B CG    1 
ATOM   5744  C  CD1   . LEU B 1 235 ? 129.315 121.071 83.008  1.00 84.64  ? 227 LEU B CD1   1 
ATOM   5745  C  CD2   . LEU B 1 235 ? 131.348 120.919 84.457  1.00 91.67  ? 227 LEU B CD2   1 
ATOM   5746  N  N     . THR B 1 236 ? 133.917 120.988 79.756  1.00 95.20  ? 228 THR B N     1 
ATOM   5747  C  CA    . THR B 1 236 ? 134.612 120.414 78.608  1.00 95.41  ? 228 THR B CA    1 
ATOM   5748  C  C     . THR B 1 236 ? 136.042 120.029 78.956  1.00 95.47  ? 228 THR B C     1 
ATOM   5749  O  O     . THR B 1 236 ? 136.586 119.077 78.384  1.00 90.69  ? 228 THR B O     1 
ATOM   5750  C  CB    . THR B 1 236 ? 134.605 121.400 77.440  1.00 98.38  ? 228 THR B CB    1 
ATOM   5751  O  OG1   . THR B 1 236 ? 135.325 122.583 77.808  1.00 101.62 ? 228 THR B OG1   1 
ATOM   5752  C  CG2   . THR B 1 236 ? 133.181 121.776 77.073  1.00 97.78  ? 228 THR B CG2   1 
ATOM   5753  N  N     . LYS B 1 237 ? 136.668 120.752 79.886  1.00 99.90  ? 229 LYS B N     1 
ATOM   5754  C  CA    . LYS B 1 237 ? 138.010 120.394 80.324  1.00 101.53 ? 229 LYS B CA    1 
ATOM   5755  C  C     . LYS B 1 237 ? 138.003 119.177 81.241  1.00 99.40  ? 229 LYS B C     1 
ATOM   5756  O  O     . LYS B 1 237 ? 138.980 118.420 81.268  1.00 98.02  ? 229 LYS B O     1 
ATOM   5757  C  CB    . LYS B 1 237 ? 138.666 121.583 81.029  1.00 105.47 ? 229 LYS B CB    1 
ATOM   5758  C  CG    . LYS B 1 237 ? 140.113 121.350 81.428  1.00 113.23 ? 229 LYS B CG    1 
ATOM   5759  C  CD    . LYS B 1 237 ? 140.720 122.584 82.072  1.00 119.62 ? 229 LYS B CD    1 
ATOM   5760  C  CE    . LYS B 1 237 ? 142.172 122.341 82.449  1.00 122.97 ? 229 LYS B CE    1 
ATOM   5761  N  NZ    . LYS B 1 237 ? 142.811 123.555 83.024  1.00 124.69 ? 229 LYS B NZ    1 
ATOM   5762  N  N     . THR B 1 238 ? 136.916 118.965 81.982  1.00 95.34  ? 230 THR B N     1 
ATOM   5763  C  CA    . THR B 1 238 ? 136.864 117.907 82.983  1.00 87.99  ? 230 THR B CA    1 
ATOM   5764  C  C     . THR B 1 238 ? 136.316 116.597 82.430  1.00 83.03  ? 230 THR B C     1 
ATOM   5765  O  O     . THR B 1 238 ? 136.857 115.528 82.729  1.00 79.82  ? 230 THR B O     1 
ATOM   5766  C  CB    . THR B 1 238 ? 136.013 118.356 84.173  1.00 88.68  ? 230 THR B CB    1 
ATOM   5767  O  OG1   . THR B 1 238 ? 136.468 119.635 84.626  1.00 95.34  ? 230 THR B OG1   1 
ATOM   5768  C  CG2   . THR B 1 238 ? 136.122 117.358 85.311  1.00 81.30  ? 230 THR B CG2   1 
ATOM   5769  N  N     . LEU B 1 239 ? 135.257 116.660 81.630  1.00 85.13  ? 231 LEU B N     1 
ATOM   5770  C  CA    . LEU B 1 239 ? 134.622 115.450 81.138  1.00 80.86  ? 231 LEU B CA    1 
ATOM   5771  C  C     . LEU B 1 239 ? 135.557 114.702 80.187  1.00 85.63  ? 231 LEU B C     1 
ATOM   5772  O  O     . LEU B 1 239 ? 136.447 115.302 79.579  1.00 89.25  ? 231 LEU B O     1 
ATOM   5773  C  CB    . LEU B 1 239 ? 133.313 115.788 80.430  1.00 80.30  ? 231 LEU B CB    1 
ATOM   5774  C  CG    . LEU B 1 239 ? 132.235 116.423 81.310  1.00 82.26  ? 231 LEU B CG    1 
ATOM   5775  C  CD1   . LEU B 1 239 ? 130.963 116.658 80.517  1.00 77.40  ? 231 LEU B CD1   1 
ATOM   5776  C  CD2   . LEU B 1 239 ? 131.958 115.555 82.526  1.00 73.71  ? 231 LEU B CD2   1 
ATOM   5777  N  N     . PRO B 1 240 ? 135.385 113.385 80.057  1.00 84.11  ? 232 PRO B N     1 
ATOM   5778  C  CA    . PRO B 1 240 ? 136.278 112.607 79.191  1.00 84.32  ? 232 PRO B CA    1 
ATOM   5779  C  C     . PRO B 1 240 ? 136.211 113.069 77.744  1.00 84.69  ? 232 PRO B C     1 
ATOM   5780  O  O     . PRO B 1 240 ? 135.169 113.509 77.253  1.00 83.55  ? 232 PRO B O     1 
ATOM   5781  C  CB    . PRO B 1 240 ? 135.759 111.174 79.345  1.00 83.05  ? 232 PRO B CB    1 
ATOM   5782  C  CG    . PRO B 1 240 ? 135.059 111.165 80.657  1.00 77.16  ? 232 PRO B CG    1 
ATOM   5783  C  CD    . PRO B 1 240 ? 134.444 112.523 80.791  1.00 79.33  ? 232 PRO B CD    1 
ATOM   5784  N  N     . ALA B 1 241 ? 137.352 112.962 77.059  1.00 83.42  ? 233 ALA B N     1 
ATOM   5785  C  CA    . ALA B 1 241 ? 137.456 113.441 75.687  1.00 82.34  ? 233 ALA B CA    1 
ATOM   5786  C  C     . ALA B 1 241 ? 136.651 112.602 74.704  1.00 85.40  ? 233 ALA B C     1 
ATOM   5787  O  O     . ALA B 1 241 ? 136.365 113.076 73.599  1.00 89.58  ? 233 ALA B O     1 
ATOM   5788  C  CB    . ALA B 1 241 ? 138.922 113.478 75.256  1.00 83.13  ? 233 ALA B CB    1 
ATOM   5789  N  N     . ASN B 1 242 ? 136.279 111.376 75.070  1.00 84.36  ? 234 ASN B N     1 
ATOM   5790  C  CA    . ASN B 1 242 ? 135.539 110.515 74.156  1.00 86.26  ? 234 ASN B CA    1 
ATOM   5791  C  C     . ASN B 1 242 ? 134.040 110.784 74.164  1.00 85.04  ? 234 ASN B C     1 
ATOM   5792  O  O     . ASN B 1 242 ? 133.318 110.180 73.363  1.00 85.69  ? 234 ASN B O     1 
ATOM   5793  C  CB    . ASN B 1 242 ? 135.795 109.044 74.490  1.00 89.34  ? 234 ASN B CB    1 
ATOM   5794  C  CG    . ASN B 1 242 ? 135.210 108.642 75.826  1.00 90.73  ? 234 ASN B CG    1 
ATOM   5795  O  OD1   . ASN B 1 242 ? 135.111 109.455 76.743  1.00 91.81  ? 234 ASN B OD1   1 
ATOM   5796  N  ND2   . ASN B 1 242 ? 134.817 107.379 75.944  1.00 90.58  ? 234 ASN B ND2   1 
ATOM   5797  N  N     . LEU B 1 243 ? 133.558 111.663 75.038  1.00 83.67  ? 235 LEU B N     1 
ATOM   5798  C  CA    . LEU B 1 243 ? 132.140 111.980 75.116  1.00 81.02  ? 235 LEU B CA    1 
ATOM   5799  C  C     . LEU B 1 243 ? 131.793 113.095 74.140  1.00 82.52  ? 235 LEU B C     1 
ATOM   5800  O  O     . LEU B 1 243 ? 132.527 114.080 74.015  1.00 86.02  ? 235 LEU B O     1 
ATOM   5801  C  CB    . LEU B 1 243 ? 131.760 112.389 76.540  1.00 80.39  ? 235 LEU B CB    1 
ATOM   5802  C  CG    . LEU B 1 243 ? 130.280 112.682 76.784  1.00 73.96  ? 235 LEU B CG    1 
ATOM   5803  C  CD1   . LEU B 1 243 ? 129.432 111.505 76.336  1.00 69.14  ? 235 LEU B CD1   1 
ATOM   5804  C  CD2   . LEU B 1 243 ? 130.034 112.999 78.250  1.00 64.08  ? 235 LEU B CD2   1 
ATOM   5805  N  N     . GLU B 1 244 ? 130.665 112.935 73.447  1.00 79.58  ? 236 GLU B N     1 
ATOM   5806  C  CA    . GLU B 1 244 ? 130.240 113.879 72.417  1.00 80.09  ? 236 GLU B CA    1 
ATOM   5807  C  C     . GLU B 1 244 ? 129.194 114.863 72.929  1.00 76.75  ? 236 GLU B C     1 
ATOM   5808  O  O     . GLU B 1 244 ? 129.393 116.079 72.860  1.00 79.03  ? 236 GLU B O     1 
ATOM   5809  C  CB    . GLU B 1 244 ? 129.697 113.115 71.203  1.00 88.93  ? 236 GLU B CB    1 
ATOM   5810  C  CG    . GLU B 1 244 ? 130.673 112.120 70.602  1.00 99.85  ? 236 GLU B CG    1 
ATOM   5811  C  CD    . GLU B 1 244 ? 130.077 111.355 69.436  1.00 114.32 ? 236 GLU B CD    1 
ATOM   5812  O  OE1   . GLU B 1 244 ? 128.897 111.597 69.108  1.00 118.04 ? 236 GLU B OE1   1 
ATOM   5813  O  OE2   . GLU B 1 244 ? 130.788 110.512 68.849  1.00 113.53 ? 236 GLU B OE2   1 
ATOM   5814  N  N     . ARG B 1 245 ? 128.077 114.356 73.445  1.00 72.25  ? 237 ARG B N     1 
ATOM   5815  C  CA    . ARG B 1 245 ? 126.952 115.182 73.853  1.00 67.44  ? 237 ARG B CA    1 
ATOM   5816  C  C     . ARG B 1 245 ? 126.618 114.927 75.316  1.00 63.92  ? 237 ARG B C     1 
ATOM   5817  O  O     . ARG B 1 245 ? 126.779 113.812 75.821  1.00 64.05  ? 237 ARG B O     1 
ATOM   5818  C  CB    . ARG B 1 245 ? 125.723 114.903 72.983  1.00 70.70  ? 237 ARG B CB    1 
ATOM   5819  C  CG    . ARG B 1 245 ? 125.973 115.053 71.494  1.00 74.27  ? 237 ARG B CG    1 
ATOM   5820  C  CD    . ARG B 1 245 ? 124.789 114.554 70.687  1.00 76.50  ? 237 ARG B CD    1 
ATOM   5821  N  NE    . ARG B 1 245 ? 124.482 113.160 70.984  1.00 80.48  ? 237 ARG B NE    1 
ATOM   5822  C  CZ    . ARG B 1 245 ? 123.530 112.460 70.383  1.00 80.84  ? 237 ARG B CZ    1 
ATOM   5823  N  NH1   . ARG B 1 245 ? 122.771 112.992 69.440  1.00 78.30  ? 237 ARG B NH1   1 
ATOM   5824  N  NH2   . ARG B 1 245 ? 123.335 111.193 70.737  1.00 81.02  ? 237 ARG B NH2   1 
ATOM   5825  N  N     . VAL B 1 246 ? 126.145 115.974 75.994  1.00 59.56  ? 238 VAL B N     1 
ATOM   5826  C  CA    . VAL B 1 246 ? 125.832 115.900 77.416  1.00 51.32  ? 238 VAL B CA    1 
ATOM   5827  C  C     . VAL B 1 246 ? 124.714 116.884 77.738  1.00 51.80  ? 238 VAL B C     1 
ATOM   5828  O  O     . VAL B 1 246 ? 124.496 117.871 77.030  1.00 56.84  ? 238 VAL B O     1 
ATOM   5829  C  CB    . VAL B 1 246 ? 127.081 116.177 78.289  1.00 56.30  ? 238 VAL B CB    1 
ATOM   5830  C  CG1   . VAL B 1 246 ? 127.394 117.662 78.331  1.00 55.36  ? 238 VAL B CG1   1 
ATOM   5831  C  CG2   . VAL B 1 246 ? 126.902 115.611 79.692  1.00 53.96  ? 238 VAL B CG2   1 
ATOM   5832  N  N     . ILE B 1 247 ? 123.984 116.591 78.812  1.00 47.76  ? 239 ILE B N     1 
ATOM   5833  C  CA    . ILE B 1 247 ? 122.936 117.458 79.337  1.00 43.29  ? 239 ILE B CA    1 
ATOM   5834  C  C     . ILE B 1 247 ? 123.399 117.946 80.701  1.00 44.76  ? 239 ILE B C     1 
ATOM   5835  O  O     . ILE B 1 247 ? 123.490 117.161 81.650  1.00 50.10  ? 239 ILE B O     1 
ATOM   5836  C  CB    . ILE B 1 247 ? 121.592 116.727 79.443  1.00 39.58  ? 239 ILE B CB    1 
ATOM   5837  C  CG1   . ILE B 1 247 ? 121.205 116.109 78.100  1.00 43.93  ? 239 ILE B CG1   1 
ATOM   5838  C  CG2   . ILE B 1 247 ? 120.510 117.670 79.934  1.00 42.98  ? 239 ILE B CG2   1 
ATOM   5839  C  CD1   . ILE B 1 247 ? 119.883 115.385 78.132  1.00 45.72  ? 239 ILE B CD1   1 
ATOM   5840  N  N     . VAL B 1 248 ? 123.691 119.232 80.810  1.00 42.01  ? 240 VAL B N     1 
ATOM   5841  C  CA    . VAL B 1 248 ? 124.146 119.822 82.062  1.00 40.77  ? 240 VAL B CA    1 
ATOM   5842  C  C     . VAL B 1 248 ? 122.934 120.325 82.833  1.00 45.91  ? 240 VAL B C     1 
ATOM   5843  O  O     . VAL B 1 248 ? 122.105 121.067 82.292  1.00 52.22  ? 240 VAL B O     1 
ATOM   5844  C  CB    . VAL B 1 248 ? 125.146 120.959 81.803  1.00 42.97  ? 240 VAL B CB    1 
ATOM   5845  C  CG1   . VAL B 1 248 ? 125.625 121.553 83.114  1.00 41.94  ? 240 VAL B CG1   1 
ATOM   5846  C  CG2   . VAL B 1 248 ? 126.315 120.452 80.982  1.00 41.25  ? 240 VAL B CG2   1 
ATOM   5847  N  N     . LEU B 1 249 ? 122.831 119.925 84.096  1.00 48.22  ? 241 LEU B N     1 
ATOM   5848  C  CA    . LEU B 1 249 ? 121.697 120.286 84.933  1.00 47.06  ? 241 LEU B CA    1 
ATOM   5849  C  C     . LEU B 1 249 ? 122.167 120.974 86.207  1.00 46.87  ? 241 LEU B C     1 
ATOM   5850  O  O     . LEU B 1 249 ? 123.340 120.911 86.583  1.00 49.07  ? 241 LEU B O     1 
ATOM   5851  C  CB    . LEU B 1 249 ? 120.857 119.056 85.294  1.00 47.48  ? 241 LEU B CB    1 
ATOM   5852  C  CG    . LEU B 1 249 ? 120.174 118.332 84.135  1.00 42.70  ? 241 LEU B CG    1 
ATOM   5853  C  CD1   . LEU B 1 249 ? 119.288 117.216 84.658  1.00 43.45  ? 241 LEU B CD1   1 
ATOM   5854  C  CD2   . LEU B 1 249 ? 119.373 119.308 83.296  1.00 43.30  ? 241 LEU B CD2   1 
ATOM   5855  N  N     . ASP B 1 250 ? 121.228 121.647 86.864  1.00 49.77  ? 242 ASP B N     1 
ATOM   5856  C  CA    . ASP B 1 250 ? 121.439 122.223 88.181  1.00 53.74  ? 242 ASP B CA    1 
ATOM   5857  C  C     . ASP B 1 250 ? 120.718 121.388 89.230  1.00 52.56  ? 242 ASP B C     1 
ATOM   5858  O  O     . ASP B 1 250 ? 119.827 120.594 88.922  1.00 51.62  ? 242 ASP B O     1 
ATOM   5859  C  CB    . ASP B 1 250 ? 120.958 123.676 88.238  1.00 54.95  ? 242 ASP B CB    1 
ATOM   5860  C  CG    . ASP B 1 250 ? 121.963 124.642 87.653  1.00 64.09  ? 242 ASP B CG    1 
ATOM   5861  O  OD1   . ASP B 1 250 ? 123.004 124.179 87.141  1.00 63.76  ? 242 ASP B OD1   1 
ATOM   5862  O  OD2   . ASP B 1 250 ? 121.719 125.865 87.709  1.00 69.43  ? 242 ASP B OD2   1 
ATOM   5863  N  N     . THR B 1 251 ? 121.120 121.581 90.487  1.00 50.38  ? 243 THR B N     1 
ATOM   5864  C  CA    . THR B 1 251 ? 120.589 120.767 91.572  1.00 49.35  ? 243 THR B CA    1 
ATOM   5865  C  C     . THR B 1 251 ? 119.119 121.046 91.854  1.00 51.34  ? 243 THR B C     1 
ATOM   5866  O  O     . THR B 1 251 ? 118.449 120.206 92.464  1.00 52.66  ? 243 THR B O     1 
ATOM   5867  C  CB    . THR B 1 251 ? 121.414 120.991 92.838  1.00 53.10  ? 243 THR B CB    1 
ATOM   5868  O  OG1   . THR B 1 251 ? 121.434 122.389 93.154  1.00 60.22  ? 243 THR B OG1   1 
ATOM   5869  C  CG2   . THR B 1 251 ? 122.838 120.506 92.633  1.00 48.01  ? 243 THR B CG2   1 
ATOM   5870  N  N     . ASP B 1 252 ? 118.599 122.192 91.418  1.00 52.75  ? 244 ASP B N     1 
ATOM   5871  C  CA    . ASP B 1 252 ? 117.219 122.595 91.681  1.00 48.91  ? 244 ASP B CA    1 
ATOM   5872  C  C     . ASP B 1 252 ? 116.308 122.332 90.490  1.00 49.54  ? 244 ASP B C     1 
ATOM   5873  O  O     . ASP B 1 252 ? 115.369 123.090 90.234  1.00 50.61  ? 244 ASP B O     1 
ATOM   5874  C  CB    . ASP B 1 252 ? 117.174 124.065 92.082  1.00 49.01  ? 244 ASP B CB    1 
ATOM   5875  C  CG    . ASP B 1 252 ? 118.059 124.928 91.212  1.00 52.46  ? 244 ASP B CG    1 
ATOM   5876  O  OD1   . ASP B 1 252 ? 118.481 124.452 90.140  1.00 54.26  ? 244 ASP B OD1   1 
ATOM   5877  O  OD2   . ASP B 1 252 ? 118.340 126.080 91.600  1.00 56.52  ? 244 ASP B OD2   1 
ATOM   5878  N  N     . ILE B 1 253 ? 116.560 121.256 89.751  1.00 51.53  ? 245 ILE B N     1 
ATOM   5879  C  CA    . ILE B 1 253 ? 115.810 120.913 88.550  1.00 46.56  ? 245 ILE B CA    1 
ATOM   5880  C  C     . ILE B 1 253 ? 114.942 119.699 88.847  1.00 45.79  ? 245 ILE B C     1 
ATOM   5881  O  O     . ILE B 1 253 ? 115.365 118.781 89.559  1.00 50.71  ? 245 ILE B O     1 
ATOM   5882  C  CB    . ILE B 1 253 ? 116.759 120.640 87.365  1.00 45.86  ? 245 ILE B CB    1 
ATOM   5883  C  CG1   . ILE B 1 253 ? 117.541 121.903 87.002  1.00 50.15  ? 245 ILE B CG1   1 
ATOM   5884  C  CG2   . ILE B 1 253 ? 115.993 120.133 86.158  1.00 47.68  ? 245 ILE B CG2   1 
ATOM   5885  C  CD1   . ILE B 1 253 ? 116.684 123.011 86.444  1.00 54.36  ? 245 ILE B CD1   1 
ATOM   5886  N  N     . THR B 1 254 ? 113.721 119.704 88.319  1.00 45.00  ? 246 THR B N     1 
ATOM   5887  C  CA    . THR B 1 254 ? 112.813 118.574 88.427  1.00 49.73  ? 246 THR B CA    1 
ATOM   5888  C  C     . THR B 1 254 ? 112.302 118.221 87.039  1.00 52.61  ? 246 THR B C     1 
ATOM   5889  O  O     . THR B 1 254 ? 111.998 119.108 86.237  1.00 57.28  ? 246 THR B O     1 
ATOM   5890  C  CB    . THR B 1 254 ? 111.636 118.888 89.358  1.00 55.75  ? 246 THR B CB    1 
ATOM   5891  O  OG1   . THR B 1 254 ? 112.131 119.431 90.587  1.00 60.65  ? 246 THR B OG1   1 
ATOM   5892  C  CG2   . THR B 1 254 ? 110.843 117.628 89.658  1.00 59.58  ? 246 THR B CG2   1 
ATOM   5893  N  N     . PHE B 1 255 ? 112.217 116.926 86.757  1.00 54.30  ? 247 PHE B N     1 
ATOM   5894  C  CA    . PHE B 1 255 ? 111.784 116.429 85.459  1.00 57.77  ? 247 PHE B CA    1 
ATOM   5895  C  C     . PHE B 1 255 ? 110.383 115.847 85.570  1.00 63.98  ? 247 PHE B C     1 
ATOM   5896  O  O     . PHE B 1 255 ? 110.130 114.981 86.415  1.00 62.06  ? 247 PHE B O     1 
ATOM   5897  C  CB    . PHE B 1 255 ? 112.753 115.371 84.927  1.00 53.36  ? 247 PHE B CB    1 
ATOM   5898  C  CG    . PHE B 1 255 ? 113.871 115.934 84.101  1.00 45.06  ? 247 PHE B CG    1 
ATOM   5899  C  CD1   . PHE B 1 255 ? 114.767 116.836 84.645  1.00 46.47  ? 247 PHE B CD1   1 
ATOM   5900  C  CD2   . PHE B 1 255 ? 114.031 115.553 82.782  1.00 48.55  ? 247 PHE B CD2   1 
ATOM   5901  C  CE1   . PHE B 1 255 ? 115.795 117.354 83.885  1.00 45.07  ? 247 PHE B CE1   1 
ATOM   5902  C  CE2   . PHE B 1 255 ? 115.059 116.067 82.019  1.00 51.85  ? 247 PHE B CE2   1 
ATOM   5903  C  CZ    . PHE B 1 255 ? 115.942 116.968 82.572  1.00 47.64  ? 247 PHE B CZ    1 
ATOM   5904  N  N     . ALA B 1 256 ? 109.478 116.327 84.719  1.00 64.32  ? 248 ALA B N     1 
ATOM   5905  C  CA    . ALA B 1 256 ? 108.137 115.773 84.608  1.00 68.74  ? 248 ALA B CA    1 
ATOM   5906  C  C     . ALA B 1 256 ? 107.930 115.004 83.312  1.00 71.92  ? 248 ALA B C     1 
ATOM   5907  O  O     . ALA B 1 256 ? 106.814 114.543 83.051  1.00 77.30  ? 248 ALA B O     1 
ATOM   5908  C  CB    . ALA B 1 256 ? 107.089 116.885 84.723  1.00 76.20  ? 248 ALA B CB    1 
ATOM   5909  N  N     . THR B 1 257 ? 108.972 114.854 82.498  1.00 68.78  ? 249 THR B N     1 
ATOM   5910  C  CA    . THR B 1 257 ? 108.892 114.118 81.246  1.00 71.22  ? 249 THR B CA    1 
ATOM   5911  C  C     . THR B 1 257 ? 110.154 113.284 81.090  1.00 68.99  ? 249 THR B C     1 
ATOM   5912  O  O     . THR B 1 257 ? 111.135 113.458 81.818  1.00 67.78  ? 249 THR B O     1 
ATOM   5913  C  CB    . THR B 1 257 ? 108.724 115.053 80.044  1.00 75.29  ? 249 THR B CB    1 
ATOM   5914  O  OG1   . THR B 1 257 ? 108.266 114.301 78.913  1.00 80.14  ? 249 THR B OG1   1 
ATOM   5915  C  CG2   . THR B 1 257 ? 110.051 115.705 79.696  1.00 71.09  ? 249 THR B CG2   1 
ATOM   5916  N  N     . ASP B 1 258 ? 110.118 112.362 80.131  1.00 70.94  ? 250 ASP B N     1 
ATOM   5917  C  CA    . ASP B 1 258 ? 111.273 111.517 79.864  1.00 71.13  ? 250 ASP B CA    1 
ATOM   5918  C  C     . ASP B 1 258 ? 112.449 112.360 79.390  1.00 70.44  ? 250 ASP B C     1 
ATOM   5919  O  O     . ASP B 1 258 ? 112.296 113.243 78.542  1.00 71.05  ? 250 ASP B O     1 
ATOM   5920  C  CB    . ASP B 1 258 ? 110.921 110.461 78.817  1.00 76.55  ? 250 ASP B CB    1 
ATOM   5921  C  CG    . ASP B 1 258 ? 112.028 109.444 78.613  1.00 80.41  ? 250 ASP B CG    1 
ATOM   5922  O  OD1   . ASP B 1 258 ? 113.039 109.498 79.344  1.00 77.97  ? 250 ASP B OD1   1 
ATOM   5923  O  OD2   . ASP B 1 258 ? 111.885 108.584 77.718  1.00 83.64  ? 250 ASP B OD2   1 
ATOM   5924  N  N     . ILE B 1 259 ? 113.631 112.084 79.947  1.00 70.78  ? 251 ILE B N     1 
ATOM   5925  C  CA    . ILE B 1 259 ? 114.829 112.802 79.533  1.00 67.51  ? 251 ILE B CA    1 
ATOM   5926  C  C     . ILE B 1 259 ? 115.261 112.387 78.134  1.00 68.03  ? 251 ILE B C     1 
ATOM   5927  O  O     . ILE B 1 259 ? 116.024 113.110 77.481  1.00 68.40  ? 251 ILE B O     1 
ATOM   5928  C  CB    . ILE B 1 259 ? 115.956 112.587 80.562  1.00 64.74  ? 251 ILE B CB    1 
ATOM   5929  C  CG1   . ILE B 1 259 ? 117.078 113.607 80.354  1.00 55.81  ? 251 ILE B CG1   1 
ATOM   5930  C  CG2   . ILE B 1 259 ? 116.491 111.167 80.484  1.00 63.71  ? 251 ILE B CG2   1 
ATOM   5931  C  CD1   . ILE B 1 259 ? 118.104 113.610 81.455  1.00 55.54  ? 251 ILE B CD1   1 
ATOM   5932  N  N     . ALA B 1 260 ? 114.785 111.236 77.651  1.00 67.96  ? 252 ALA B N     1 
ATOM   5933  C  CA    . ALA B 1 260 ? 115.067 110.841 76.277  1.00 67.20  ? 252 ALA B CA    1 
ATOM   5934  C  C     . ALA B 1 260 ? 114.478 111.831 75.284  1.00 67.90  ? 252 ALA B C     1 
ATOM   5935  O  O     . ALA B 1 260 ? 115.040 112.034 74.204  1.00 67.76  ? 252 ALA B O     1 
ATOM   5936  C  CB    . ALA B 1 260 ? 114.528 109.437 76.011  1.00 70.42  ? 252 ALA B CB    1 
ATOM   5937  N  N     . GLU B 1 261 ? 113.355 112.462 75.634  1.00 66.58  ? 253 GLU B N     1 
ATOM   5938  C  CA    . GLU B 1 261 ? 112.784 113.487 74.767  1.00 66.87  ? 253 GLU B CA    1 
ATOM   5939  C  C     . GLU B 1 261 ? 113.734 114.668 74.615  1.00 63.67  ? 253 GLU B C     1 
ATOM   5940  O  O     . GLU B 1 261 ? 113.892 115.210 73.516  1.00 63.38  ? 253 GLU B O     1 
ATOM   5941  C  CB    . GLU B 1 261 ? 111.436 113.947 75.320  1.00 68.55  ? 253 GLU B CB    1 
ATOM   5942  C  CG    . GLU B 1 261 ? 110.435 112.824 75.517  1.00 71.67  ? 253 GLU B CG    1 
ATOM   5943  C  CD    . GLU B 1 261 ? 109.116 113.313 76.079  1.00 81.50  ? 253 GLU B CD    1 
ATOM   5944  O  OE1   . GLU B 1 261 ? 108.962 114.541 76.252  1.00 78.68  ? 253 GLU B OE1   1 
ATOM   5945  O  OE2   . GLU B 1 261 ? 108.233 112.471 76.348  1.00 86.33  ? 253 GLU B OE2   1 
ATOM   5946  N  N     . LEU B 1 262 ? 114.374 115.084 75.710  1.00 62.78  ? 254 LEU B N     1 
ATOM   5947  C  CA    . LEU B 1 262 ? 115.352 116.162 75.626  1.00 62.57  ? 254 LEU B CA    1 
ATOM   5948  C  C     . LEU B 1 262 ? 116.622 115.711 74.916  1.00 64.44  ? 254 LEU B C     1 
ATOM   5949  O  O     . LEU B 1 262 ? 117.250 116.507 74.208  1.00 62.22  ? 254 LEU B O     1 
ATOM   5950  C  CB    . LEU B 1 262 ? 115.680 116.686 77.024  1.00 56.67  ? 254 LEU B CB    1 
ATOM   5951  C  CG    . LEU B 1 262 ? 116.687 117.833 77.102  1.00 50.73  ? 254 LEU B CG    1 
ATOM   5952  C  CD1   . LEU B 1 262 ? 116.230 119.000 76.250  1.00 56.73  ? 254 LEU B CD1   1 
ATOM   5953  C  CD2   . LEU B 1 262 ? 116.889 118.268 78.540  1.00 49.69  ? 254 LEU B CD2   1 
ATOM   5954  N  N     . TRP B 1 263 ? 117.019 114.450 75.096  1.00 66.50  ? 255 TRP B N     1 
ATOM   5955  C  CA    . TRP B 1 263 ? 118.195 113.941 74.397  1.00 65.47  ? 255 TRP B CA    1 
ATOM   5956  C  C     . TRP B 1 263 ? 117.961 113.859 72.895  1.00 66.96  ? 255 TRP B C     1 
ATOM   5957  O  O     . TRP B 1 263 ? 118.904 114.012 72.111  1.00 69.10  ? 255 TRP B O     1 
ATOM   5958  C  CB    . TRP B 1 263 ? 118.583 112.572 74.953  1.00 67.42  ? 255 TRP B CB    1 
ATOM   5959  C  CG    . TRP B 1 263 ? 119.824 111.997 74.343  1.00 67.99  ? 255 TRP B CG    1 
ATOM   5960  C  CD1   . TRP B 1 263 ? 119.893 111.060 73.356  1.00 69.76  ? 255 TRP B CD1   1 
ATOM   5961  C  CD2   . TRP B 1 263 ? 121.177 112.321 74.684  1.00 67.63  ? 255 TRP B CD2   1 
ATOM   5962  N  NE1   . TRP B 1 263 ? 121.204 110.779 73.060  1.00 70.64  ? 255 TRP B NE1   1 
ATOM   5963  C  CE2   . TRP B 1 263 ? 122.012 111.541 73.862  1.00 69.67  ? 255 TRP B CE2   1 
ATOM   5964  C  CE3   . TRP B 1 263 ? 121.763 113.195 75.603  1.00 64.38  ? 255 TRP B CE3   1 
ATOM   5965  C  CZ2   . TRP B 1 263 ? 123.400 111.609 73.931  1.00 68.13  ? 255 TRP B CZ2   1 
ATOM   5966  C  CZ3   . TRP B 1 263 ? 123.141 113.260 75.670  1.00 61.31  ? 255 TRP B CZ3   1 
ATOM   5967  C  CH2   . TRP B 1 263 ? 123.943 112.472 74.840  1.00 63.84  ? 255 TRP B CH2   1 
ATOM   5968  N  N     . ALA B 1 264 ? 116.717 113.616 72.479  1.00 66.53  ? 256 ALA B N     1 
ATOM   5969  C  CA    . ALA B 1 264 ? 116.389 113.578 71.060  1.00 66.59  ? 256 ALA B CA    1 
ATOM   5970  C  C     . ALA B 1 264 ? 116.526 114.941 70.397  1.00 69.13  ? 256 ALA B C     1 
ATOM   5971  O  O     . ALA B 1 264 ? 116.659 115.007 69.171  1.00 77.53  ? 256 ALA B O     1 
ATOM   5972  C  CB    . ALA B 1 264 ? 114.970 113.046 70.863  1.00 64.07  ? 256 ALA B CB    1 
ATOM   5973  N  N     . VAL B 1 265 ? 116.496 116.026 71.174  1.00 64.53  ? 257 VAL B N     1 
ATOM   5974  C  CA    . VAL B 1 265 ? 116.660 117.357 70.604  1.00 65.71  ? 257 VAL B CA    1 
ATOM   5975  C  C     . VAL B 1 265 ? 118.055 117.546 70.024  1.00 68.43  ? 257 VAL B C     1 
ATOM   5976  O  O     . VAL B 1 265 ? 118.263 118.438 69.194  1.00 70.96  ? 257 VAL B O     1 
ATOM   5977  C  CB    . VAL B 1 265 ? 116.347 118.429 71.665  1.00 66.50  ? 257 VAL B CB    1 
ATOM   5978  C  CG1   . VAL B 1 265 ? 116.245 119.807 71.030  1.00 64.00  ? 257 VAL B CG1   1 
ATOM   5979  C  CG2   . VAL B 1 265 ? 115.059 118.088 72.395  1.00 66.65  ? 257 VAL B CG2   1 
ATOM   5980  N  N     . PHE B 1 266 ? 119.021 116.719 70.430  1.00 70.69  ? 258 PHE B N     1 
ATOM   5981  C  CA    . PHE B 1 266 ? 120.362 116.823 69.866  1.00 72.44  ? 258 PHE B CA    1 
ATOM   5982  C  C     . PHE B 1 266 ? 120.366 116.548 68.368  1.00 75.07  ? 258 PHE B C     1 
ATOM   5983  O  O     . PHE B 1 266 ? 121.221 117.072 67.644  1.00 77.14  ? 258 PHE B O     1 
ATOM   5984  C  CB    . PHE B 1 266 ? 121.316 115.869 70.585  1.00 68.83  ? 258 PHE B CB    1 
ATOM   5985  C  CG    . PHE B 1 266 ? 121.894 116.430 71.852  1.00 65.91  ? 258 PHE B CG    1 
ATOM   5986  C  CD1   . PHE B 1 266 ? 122.809 117.468 71.808  1.00 64.60  ? 258 PHE B CD1   1 
ATOM   5987  C  CD2   . PHE B 1 266 ? 121.533 115.915 73.083  1.00 66.62  ? 258 PHE B CD2   1 
ATOM   5988  C  CE1   . PHE B 1 266 ? 123.346 117.987 72.970  1.00 61.40  ? 258 PHE B CE1   1 
ATOM   5989  C  CE2   . PHE B 1 266 ? 122.068 116.428 74.247  1.00 63.54  ? 258 PHE B CE2   1 
ATOM   5990  C  CZ    . PHE B 1 266 ? 122.976 117.465 74.190  1.00 61.18  ? 258 PHE B CZ    1 
ATOM   5991  N  N     . HIS B 1 267 ? 119.424 115.736 67.884  1.00 73.97  ? 259 HIS B N     1 
ATOM   5992  C  CA    . HIS B 1 267 ? 119.341 115.460 66.455  1.00 73.29  ? 259 HIS B CA    1 
ATOM   5993  C  C     . HIS B 1 267 ? 118.939 116.686 65.647  1.00 72.26  ? 259 HIS B C     1 
ATOM   5994  O  O     . HIS B 1 267 ? 119.179 116.719 64.436  1.00 76.94  ? 259 HIS B O     1 
ATOM   5995  C  CB    . HIS B 1 267 ? 118.348 114.328 66.193  1.00 72.69  ? 259 HIS B CB    1 
ATOM   5996  C  CG    . HIS B 1 267 ? 118.704 113.041 66.869  1.00 77.52  ? 259 HIS B CG    1 
ATOM   5997  N  ND1   . HIS B 1 267 ? 119.933 112.437 66.718  1.00 82.18  ? 259 HIS B ND1   1 
ATOM   5998  C  CD2   . HIS B 1 267 ? 117.988 112.239 67.692  1.00 80.57  ? 259 HIS B CD2   1 
ATOM   5999  C  CE1   . HIS B 1 267 ? 119.961 111.320 67.423  1.00 86.38  ? 259 HIS B CE1   1 
ATOM   6000  N  NE2   . HIS B 1 267 ? 118.794 111.177 68.024  1.00 86.47  ? 259 HIS B NE2   1 
ATOM   6001  N  N     . LYS B 1 268 ? 118.341 117.688 66.283  1.00 68.31  ? 260 LYS B N     1 
ATOM   6002  C  CA    . LYS B 1 268 ? 117.824 118.855 65.583  1.00 70.80  ? 260 LYS B CA    1 
ATOM   6003  C  C     . LYS B 1 268 ? 118.823 120.003 65.509  1.00 70.77  ? 260 LYS B C     1 
ATOM   6004  O  O     . LYS B 1 268 ? 118.491 121.056 64.955  1.00 74.86  ? 260 LYS B O     1 
ATOM   6005  C  CB    . LYS B 1 268 ? 116.535 119.333 66.256  1.00 68.85  ? 260 LYS B CB    1 
ATOM   6006  C  CG    . LYS B 1 268 ? 115.492 118.240 66.411  1.00 70.55  ? 260 LYS B CG    1 
ATOM   6007  C  CD    . LYS B 1 268 ? 114.298 118.717 67.218  1.00 77.25  ? 260 LYS B CD    1 
ATOM   6008  C  CE    . LYS B 1 268 ? 113.307 117.588 67.446  1.00 79.03  ? 260 LYS B CE    1 
ATOM   6009  N  NZ    . LYS B 1 268 ? 112.139 118.028 68.257  1.00 76.96  ? 260 LYS B NZ    1 
ATOM   6010  N  N     . PHE B 1 269 ? 120.024 119.834 66.052  1.00 69.68  ? 261 PHE B N     1 
ATOM   6011  C  CA    . PHE B 1 269 ? 121.040 120.873 65.953  1.00 71.31  ? 261 PHE B CA    1 
ATOM   6012  C  C     . PHE B 1 269 ? 121.528 121.003 64.516  1.00 81.56  ? 261 PHE B C     1 
ATOM   6013  O  O     . PHE B 1 269 ? 121.722 120.007 63.814  1.00 84.13  ? 261 PHE B O     1 
ATOM   6014  C  CB    . PHE B 1 269 ? 122.215 120.561 66.878  1.00 72.98  ? 261 PHE B CB    1 
ATOM   6015  C  CG    . PHE B 1 269 ? 121.940 120.840 68.327  1.00 71.58  ? 261 PHE B CG    1 
ATOM   6016  C  CD1   . PHE B 1 269 ? 121.010 120.092 69.026  1.00 70.09  ? 261 PHE B CD1   1 
ATOM   6017  C  CD2   . PHE B 1 269 ? 122.623 121.841 68.994  1.00 74.21  ? 261 PHE B CD2   1 
ATOM   6018  C  CE1   . PHE B 1 269 ? 120.757 120.343 70.359  1.00 70.06  ? 261 PHE B CE1   1 
ATOM   6019  C  CE2   . PHE B 1 269 ? 122.376 122.097 70.329  1.00 72.94  ? 261 PHE B CE2   1 
ATOM   6020  C  CZ    . PHE B 1 269 ? 121.441 121.346 71.012  1.00 70.19  ? 261 PHE B CZ    1 
ATOM   6021  N  N     . LYS B 1 270 ? 121.724 122.244 64.077  1.00 85.16  ? 262 LYS B N     1 
ATOM   6022  C  CA    . LYS B 1 270 ? 122.214 122.525 62.737  1.00 81.37  ? 262 LYS B CA    1 
ATOM   6023  C  C     . LYS B 1 270 ? 123.233 123.652 62.803  1.00 83.86  ? 262 LYS B C     1 
ATOM   6024  O  O     . LYS B 1 270 ? 123.228 124.469 63.727  1.00 86.79  ? 262 LYS B O     1 
ATOM   6025  C  CB    . LYS B 1 270 ? 121.075 122.901 61.779  1.00 81.02  ? 262 LYS B CB    1 
ATOM   6026  C  CG    . LYS B 1 270 ? 120.089 121.779 61.506  1.00 80.25  ? 262 LYS B CG    1 
ATOM   6027  C  CD    . LYS B 1 270 ? 119.001 122.227 60.544  1.00 88.79  ? 262 LYS B CD    1 
ATOM   6028  C  CE    . LYS B 1 270 ? 118.014 121.105 60.263  1.00 90.47  ? 262 LYS B CE    1 
ATOM   6029  N  NZ    . LYS B 1 270 ? 116.945 121.529 59.318  1.00 95.93  ? 262 LYS B NZ    1 
ATOM   6030  N  N     . GLY B 1 271 ? 124.107 123.691 61.800  1.00 84.63  ? 263 GLY B N     1 
ATOM   6031  C  CA    . GLY B 1 271 ? 125.117 124.735 61.751  1.00 85.59  ? 263 GLY B CA    1 
ATOM   6032  C  C     . GLY B 1 271 ? 126.090 124.625 62.908  1.00 82.48  ? 263 GLY B C     1 
ATOM   6033  O  O     . GLY B 1 271 ? 126.509 123.532 63.302  1.00 84.18  ? 263 GLY B O     1 
ATOM   6034  N  N     . GLN B 1 272 ? 126.456 125.777 63.465  1.00 84.56  ? 264 GLN B N     1 
ATOM   6035  C  CA    . GLN B 1 272 ? 127.401 125.846 64.570  1.00 89.38  ? 264 GLN B CA    1 
ATOM   6036  C  C     . GLN B 1 272 ? 126.717 125.977 65.925  1.00 88.22  ? 264 GLN B C     1 
ATOM   6037  O  O     . GLN B 1 272 ? 127.396 126.216 66.929  1.00 89.65  ? 264 GLN B O     1 
ATOM   6038  C  CB    . GLN B 1 272 ? 128.375 127.006 64.359  1.00 92.52  ? 264 GLN B CB    1 
ATOM   6039  C  CG    . GLN B 1 272 ? 129.173 126.906 63.071  1.00 95.83  ? 264 GLN B CG    1 
ATOM   6040  C  CD    . GLN B 1 272 ? 130.318 127.896 63.018  1.00 107.25 ? 264 GLN B CD    1 
ATOM   6041  O  OE1   . GLN B 1 272 ? 130.763 128.404 64.047  1.00 107.51 ? 264 GLN B OE1   1 
ATOM   6042  N  NE2   . GLN B 1 272 ? 130.803 128.176 61.814  1.00 107.84 ? 264 GLN B NE2   1 
ATOM   6043  N  N     . GLN B 1 273 ? 125.395 125.835 65.977  1.00 87.82  ? 265 GLN B N     1 
ATOM   6044  C  CA    . GLN B 1 273 ? 124.682 125.861 67.248  1.00 85.65  ? 265 GLN B CA    1 
ATOM   6045  C  C     . GLN B 1 273 ? 125.095 124.659 68.088  1.00 84.53  ? 265 GLN B C     1 
ATOM   6046  O  O     . GLN B 1 273 ? 124.923 123.511 67.667  1.00 86.35  ? 265 GLN B O     1 
ATOM   6047  C  CB    . GLN B 1 273 ? 123.174 125.856 67.011  1.00 82.52  ? 265 GLN B CB    1 
ATOM   6048  C  CG    . GLN B 1 273 ? 122.646 127.087 66.298  1.00 82.24  ? 265 GLN B CG    1 
ATOM   6049  C  CD    . GLN B 1 273 ? 121.180 126.969 65.941  1.00 85.26  ? 265 GLN B CD    1 
ATOM   6050  O  OE1   . GLN B 1 273 ? 120.642 125.867 65.843  1.00 86.68  ? 265 GLN B OE1   1 
ATOM   6051  N  NE2   . GLN B 1 273 ? 120.524 128.106 65.745  1.00 88.25  ? 265 GLN B NE2   1 
ATOM   6052  N  N     . VAL B 1 274 ? 125.646 124.919 69.272  1.00 80.67  ? 266 VAL B N     1 
ATOM   6053  C  CA    . VAL B 1 274 ? 126.105 123.843 70.145  1.00 78.03  ? 266 VAL B CA    1 
ATOM   6054  C  C     . VAL B 1 274 ? 125.539 123.920 71.553  1.00 75.83  ? 266 VAL B C     1 
ATOM   6055  O  O     . VAL B 1 274 ? 125.462 122.883 72.235  1.00 75.70  ? 266 VAL B O     1 
ATOM   6056  C  CB    . VAL B 1 274 ? 127.648 123.815 70.194  1.00 78.58  ? 266 VAL B CB    1 
ATOM   6057  C  CG1   . VAL B 1 274 ? 128.209 123.363 68.861  1.00 82.73  ? 266 VAL B CG1   1 
ATOM   6058  C  CG2   . VAL B 1 274 ? 128.186 125.186 70.555  1.00 81.15  ? 266 VAL B CG2   1 
ATOM   6059  N  N     . LEU B 1 275 ? 125.123 125.085 72.043  1.00 73.48  ? 267 LEU B N     1 
ATOM   6060  C  CA    . LEU B 1 275 ? 124.601 125.228 73.397  1.00 66.67  ? 267 LEU B CA    1 
ATOM   6061  C  C     . LEU B 1 275 ? 123.081 125.275 73.322  1.00 67.26  ? 267 LEU B C     1 
ATOM   6062  O  O     . LEU B 1 275 ? 122.510 126.269 72.866  1.00 78.68  ? 267 LEU B O     1 
ATOM   6063  C  CB    . LEU B 1 275 ? 125.143 126.491 74.064  1.00 65.81  ? 267 LEU B CB    1 
ATOM   6064  C  CG    . LEU B 1 275 ? 126.556 126.959 73.723  1.00 73.00  ? 267 LEU B CG    1 
ATOM   6065  C  CD1   . LEU B 1 275 ? 126.847 128.275 74.423  1.00 77.01  ? 267 LEU B CD1   1 
ATOM   6066  C  CD2   . LEU B 1 275 ? 127.588 125.915 74.102  1.00 79.43  ? 267 LEU B CD2   1 
ATOM   6067  N  N     . GLY B 1 276 ? 122.426 124.210 73.770  1.00 62.31  ? 268 GLY B N     1 
ATOM   6068  C  CA    . GLY B 1 276 ? 120.978 124.200 73.791  1.00 64.13  ? 268 GLY B CA    1 
ATOM   6069  C  C     . GLY B 1 276 ? 120.440 124.874 75.035  1.00 63.90  ? 268 GLY B C     1 
ATOM   6070  O  O     . GLY B 1 276 ? 120.419 124.272 76.111  1.00 65.23  ? 268 GLY B O     1 
ATOM   6071  N  N     . LEU B 1 277 ? 119.997 126.121 74.904  1.00 67.20  ? 269 LEU B N     1 
ATOM   6072  C  CA    . LEU B 1 277 ? 119.619 126.924 76.056  1.00 65.99  ? 269 LEU B CA    1 
ATOM   6073  C  C     . LEU B 1 277 ? 118.194 127.431 75.902  1.00 68.88  ? 269 LEU B C     1 
ATOM   6074  O  O     . LEU B 1 277 ? 117.667 127.548 74.794  1.00 70.67  ? 269 LEU B O     1 
ATOM   6075  C  CB    . LEU B 1 277 ? 120.571 128.110 76.253  1.00 67.25  ? 269 LEU B CB    1 
ATOM   6076  C  CG    . LEU B 1 277 ? 122.029 127.766 76.541  1.00 62.32  ? 269 LEU B CG    1 
ATOM   6077  C  CD1   . LEU B 1 277 ? 122.808 129.010 76.932  1.00 67.26  ? 269 LEU B CD1   1 
ATOM   6078  C  CD2   . LEU B 1 277 ? 122.102 126.724 77.632  1.00 63.11  ? 269 LEU B CD2   1 
ATOM   6079  N  N     . VAL B 1 278 ? 117.576 127.734 77.039  1.00 73.61  ? 270 VAL B N     1 
ATOM   6080  C  CA    . VAL B 1 278 ? 116.225 128.277 77.100  1.00 77.33  ? 270 VAL B CA    1 
ATOM   6081  C  C     . VAL B 1 278 ? 116.327 129.751 77.463  1.00 81.01  ? 270 VAL B C     1 
ATOM   6082  O  O     . VAL B 1 278 ? 117.075 130.119 78.378  1.00 78.22  ? 270 VAL B O     1 
ATOM   6083  C  CB    . VAL B 1 278 ? 115.354 127.518 78.115  1.00 69.84  ? 270 VAL B CB    1 
ATOM   6084  C  CG1   . VAL B 1 278 ? 113.962 128.122 78.176  1.00 71.66  ? 270 VAL B CG1   1 
ATOM   6085  C  CG2   . VAL B 1 278 ? 115.283 126.045 77.754  1.00 67.47  ? 270 VAL B CG2   1 
ATOM   6086  N  N     . GLU B 1 279 ? 115.592 130.591 76.738  1.00 84.70  ? 271 GLU B N     1 
ATOM   6087  C  CA    . GLU B 1 279 ? 115.637 132.026 76.984  1.00 88.57  ? 271 GLU B CA    1 
ATOM   6088  C  C     . GLU B 1 279 ? 115.180 132.339 78.404  1.00 93.22  ? 271 GLU B C     1 
ATOM   6089  O  O     . GLU B 1 279 ? 114.229 131.741 78.915  1.00 93.05  ? 271 GLU B O     1 
ATOM   6090  C  CB    . GLU B 1 279 ? 114.763 132.767 75.972  1.00 90.66  ? 271 GLU B CB    1 
ATOM   6091  C  CG    . GLU B 1 279 ? 114.813 134.282 76.104  1.00 100.88 ? 271 GLU B CG    1 
ATOM   6092  C  CD    . GLU B 1 279 ? 113.930 134.989 75.096  1.00 110.44 ? 271 GLU B CD    1 
ATOM   6093  O  OE1   . GLU B 1 279 ? 113.257 134.297 74.303  1.00 111.48 ? 271 GLU B OE1   1 
ATOM   6094  O  OE2   . GLU B 1 279 ? 113.908 136.238 75.098  1.00 112.31 ? 271 GLU B OE2   1 
ATOM   6095  N  N     . ASN B 1 280 ? 115.877 133.276 79.043  1.00 94.95  ? 272 ASN B N     1 
ATOM   6096  C  CA    . ASN B 1 280 ? 115.547 133.660 80.408  1.00 90.44  ? 272 ASN B CA    1 
ATOM   6097  C  C     . ASN B 1 280 ? 114.129 134.214 80.474  1.00 99.26  ? 272 ASN B C     1 
ATOM   6098  O  O     . ASN B 1 280 ? 113.721 135.024 79.638  1.00 104.87 ? 272 ASN B O     1 
ATOM   6099  C  CB    . ASN B 1 280 ? 116.547 134.698 80.916  1.00 91.87  ? 272 ASN B CB    1 
ATOM   6100  C  CG    . ASN B 1 280 ? 116.499 134.872 82.420  1.00 96.46  ? 272 ASN B CG    1 
ATOM   6101  O  OD1   . ASN B 1 280 ? 115.499 134.558 83.065  1.00 100.62 ? 272 ASN B OD1   1 
ATOM   6102  N  ND2   . ASN B 1 280 ? 117.586 135.379 82.989  1.00 100.76 ? 272 ASN B ND2   1 
ATOM   6103  N  N     . GLN B 1 281 ? 113.378 133.772 81.479  1.00 98.01  ? 273 GLN B N     1 
ATOM   6104  C  CA    . GLN B 1 281 ? 111.988 134.171 81.650  1.00 97.06  ? 273 GLN B CA    1 
ATOM   6105  C  C     . GLN B 1 281 ? 111.823 135.359 82.588  1.00 99.84  ? 273 GLN B C     1 
ATOM   6106  O  O     . GLN B 1 281 ? 110.688 135.744 82.887  1.00 102.16 ? 273 GLN B O     1 
ATOM   6107  C  CB    . GLN B 1 281 ? 111.160 132.988 82.153  1.00 91.12  ? 273 GLN B CB    1 
ATOM   6108  C  CG    . GLN B 1 281 ? 111.144 131.808 81.199  1.00 90.37  ? 273 GLN B CG    1 
ATOM   6109  C  CD    . GLN B 1 281 ? 110.189 130.719 81.636  1.00 88.68  ? 273 GLN B CD    1 
ATOM   6110  O  OE1   . GLN B 1 281 ? 109.518 130.841 82.659  1.00 90.91  ? 273 GLN B OE1   1 
ATOM   6111  N  NE2   . GLN B 1 281 ? 110.121 129.644 80.859  1.00 84.84  ? 273 GLN B NE2   1 
ATOM   6112  N  N     . SER B 1 282 ? 112.918 135.946 83.055  1.00 101.91 ? 274 SER B N     1 
ATOM   6113  C  CA    . SER B 1 282 ? 112.884 137.119 83.914  1.00 104.39 ? 274 SER B CA    1 
ATOM   6114  C  C     . SER B 1 282 ? 113.407 138.333 83.159  1.00 108.77 ? 274 SER B C     1 
ATOM   6115  O  O     . SER B 1 282 ? 114.076 138.219 82.128  1.00 109.81 ? 274 SER B O     1 
ATOM   6116  C  CB    . SER B 1 282 ? 113.708 136.890 85.186  1.00 102.93 ? 274 SER B CB    1 
ATOM   6117  O  OG    . SER B 1 282 ? 115.092 136.831 84.890  1.00 102.13 ? 274 SER B OG    1 
ATOM   6118  N  N     . ASP B 1 283 ? 113.092 139.512 83.691  1.00 112.90 ? 275 ASP B N     1 
ATOM   6119  C  CA    . ASP B 1 283 ? 113.551 140.773 83.128  1.00 115.43 ? 275 ASP B CA    1 
ATOM   6120  C  C     . ASP B 1 283 ? 114.884 141.222 83.715  1.00 117.55 ? 275 ASP B C     1 
ATOM   6121  O  O     . ASP B 1 283 ? 115.184 142.421 83.703  1.00 118.42 ? 275 ASP B O     1 
ATOM   6122  C  CB    . ASP B 1 283 ? 112.492 141.857 83.334  1.00 117.12 ? 275 ASP B CB    1 
ATOM   6123  C  CG    . ASP B 1 283 ? 111.159 141.492 82.714  1.00 117.63 ? 275 ASP B CG    1 
ATOM   6124  O  OD1   . ASP B 1 283 ? 111.054 140.391 82.133  1.00 113.46 ? 275 ASP B OD1   1 
ATOM   6125  O  OD2   . ASP B 1 283 ? 110.216 142.306 82.807  1.00 117.55 ? 275 ASP B OD2   1 
ATOM   6126  N  N     . TRP B 1 284 ? 115.682 140.287 84.234  1.00 117.36 ? 276 TRP B N     1 
ATOM   6127  C  CA    . TRP B 1 284 ? 116.963 140.650 84.830  1.00 118.40 ? 276 TRP B CA    1 
ATOM   6128  C  C     . TRP B 1 284 ? 117.916 141.230 83.792  1.00 121.25 ? 276 TRP B C     1 
ATOM   6129  O  O     . TRP B 1 284 ? 118.609 142.219 84.059  1.00 123.83 ? 276 TRP B O     1 
ATOM   6130  C  CB    . TRP B 1 284 ? 117.585 139.433 85.514  1.00 115.21 ? 276 TRP B CB    1 
ATOM   6131  C  CG    . TRP B 1 284 ? 118.959 139.685 86.045  1.00 118.50 ? 276 TRP B CG    1 
ATOM   6132  C  CD1   . TRP B 1 284 ? 120.137 139.279 85.493  1.00 121.13 ? 276 TRP B CD1   1 
ATOM   6133  C  CD2   . TRP B 1 284 ? 119.301 140.411 87.232  1.00 120.17 ? 276 TRP B CD2   1 
ATOM   6134  N  NE1   . TRP B 1 284 ? 121.192 139.702 86.264  1.00 123.02 ? 276 TRP B NE1   1 
ATOM   6135  C  CE2   . TRP B 1 284 ? 120.705 140.400 87.338  1.00 122.36 ? 276 TRP B CE2   1 
ATOM   6136  C  CE3   . TRP B 1 284 ? 118.555 141.066 88.216  1.00 120.03 ? 276 TRP B CE3   1 
ATOM   6137  C  CZ2   . TRP B 1 284 ? 121.379 141.018 88.388  1.00 121.81 ? 276 TRP B CZ2   1 
ATOM   6138  C  CZ3   . TRP B 1 284 ? 119.227 141.680 89.258  1.00 119.86 ? 276 TRP B CZ3   1 
ATOM   6139  C  CH2   . TRP B 1 284 ? 120.624 141.652 89.335  1.00 120.81 ? 276 TRP B CH2   1 
ATOM   6140  N  N     . TYR B 1 285 ? 117.966 140.631 82.604  1.00 117.03 ? 277 TYR B N     1 
ATOM   6141  C  CA    . TYR B 1 285 ? 118.864 141.089 81.553  1.00 116.69 ? 277 TYR B CA    1 
ATOM   6142  C  C     . TYR B 1 285 ? 118.260 142.174 80.673  1.00 121.22 ? 277 TYR B C     1 
ATOM   6143  O  O     . TYR B 1 285 ? 118.971 142.730 79.829  1.00 121.44 ? 277 TYR B O     1 
ATOM   6144  C  CB    . TYR B 1 285 ? 119.300 139.909 80.676  1.00 117.08 ? 277 TYR B CB    1 
ATOM   6145  C  CG    . TYR B 1 285 ? 120.206 138.924 81.379  1.00 117.63 ? 277 TYR B CG    1 
ATOM   6146  C  CD1   . TYR B 1 285 ? 121.550 139.208 81.580  1.00 119.49 ? 277 TYR B CD1   1 
ATOM   6147  C  CD2   . TYR B 1 285 ? 119.719 137.706 81.837  1.00 115.19 ? 277 TYR B CD2   1 
ATOM   6148  C  CE1   . TYR B 1 285 ? 122.383 138.311 82.220  1.00 117.76 ? 277 TYR B CE1   1 
ATOM   6149  C  CE2   . TYR B 1 285 ? 120.545 136.802 82.479  1.00 112.49 ? 277 TYR B CE2   1 
ATOM   6150  C  CZ    . TYR B 1 285 ? 121.876 137.110 82.667  1.00 114.53 ? 277 TYR B CZ    1 
ATOM   6151  O  OH    . TYR B 1 285 ? 122.703 136.215 83.304  1.00 116.83 ? 277 TYR B OH    1 
ATOM   6152  N  N     . LEU B 1 286 ? 116.976 142.490 80.843  1.00 123.38 ? 278 LEU B N     1 
ATOM   6153  C  CA    . LEU B 1 286 ? 116.339 143.529 80.044  1.00 124.88 ? 278 LEU B CA    1 
ATOM   6154  C  C     . LEU B 1 286 ? 116.730 144.936 80.475  1.00 128.11 ? 278 LEU B C     1 
ATOM   6155  O  O     . LEU B 1 286 ? 116.451 145.890 79.740  1.00 130.60 ? 278 LEU B O     1 
ATOM   6156  C  CB    . LEU B 1 286 ? 114.817 143.381 80.101  1.00 124.17 ? 278 LEU B CB    1 
ATOM   6157  C  CG    . LEU B 1 286 ? 114.240 142.130 79.436  1.00 119.73 ? 278 LEU B CG    1 
ATOM   6158  C  CD1   . LEU B 1 286 ? 112.722 142.120 79.529  1.00 116.71 ? 278 LEU B CD1   1 
ATOM   6159  C  CD2   . LEU B 1 286 ? 114.690 142.042 77.988  1.00 114.12 ? 278 LEU B CD2   1 
ATOM   6160  N  N     . GLY B 1 287 ? 117.362 145.091 81.634  1.00 127.75 ? 279 GLY B N     1 
ATOM   6161  C  CA    . GLY B 1 287 ? 117.771 146.400 82.110  1.00 128.57 ? 279 GLY B CA    1 
ATOM   6162  C  C     . GLY B 1 287 ? 116.629 147.213 82.686  1.00 128.38 ? 279 GLY B C     1 
ATOM   6163  O  O     . GLY B 1 287 ? 115.788 147.729 81.950  1.00 128.06 ? 279 GLY B O     1 
ATOM   6164  N  N     . PRO B 1 295 ? 123.152 145.225 84.420  1.00 124.28 ? 287 PRO B N     1 
ATOM   6165  C  CA    . PRO B 1 295 ? 123.573 143.823 84.502  1.00 127.92 ? 287 PRO B CA    1 
ATOM   6166  C  C     . PRO B 1 295 ? 124.510 143.426 83.366  1.00 133.75 ? 287 PRO B C     1 
ATOM   6167  O  O     . PRO B 1 295 ? 124.894 144.273 82.559  1.00 135.42 ? 287 PRO B O     1 
ATOM   6168  C  CB    . PRO B 1 295 ? 122.251 143.058 84.408  1.00 123.36 ? 287 PRO B CB    1 
ATOM   6169  C  CG    . PRO B 1 295 ? 121.368 143.953 83.616  1.00 121.41 ? 287 PRO B CG    1 
ATOM   6170  C  CD    . PRO B 1 295 ? 121.739 145.353 84.022  1.00 123.29 ? 287 PRO B CD    1 
ATOM   6171  N  N     . TRP B 1 296 ? 124.875 142.149 83.314  1.00 133.57 ? 288 TRP B N     1 
ATOM   6172  C  CA    . TRP B 1 296 ? 125.751 141.671 82.257  1.00 131.92 ? 288 TRP B CA    1 
ATOM   6173  C  C     . TRP B 1 296 ? 125.036 141.729 80.909  1.00 129.87 ? 288 TRP B C     1 
ATOM   6174  O  O     . TRP B 1 296 ? 123.834 141.457 80.830  1.00 129.80 ? 288 TRP B O     1 
ATOM   6175  C  CB    . TRP B 1 296 ? 126.209 140.243 82.547  1.00 130.15 ? 288 TRP B CB    1 
ATOM   6176  C  CG    . TRP B 1 296 ? 127.396 140.176 83.453  1.00 134.54 ? 288 TRP B CG    1 
ATOM   6177  C  CD1   . TRP B 1 296 ? 127.525 140.755 84.680  1.00 137.12 ? 288 TRP B CD1   1 
ATOM   6178  C  CD2   . TRP B 1 296 ? 128.625 139.483 83.206  1.00 137.55 ? 288 TRP B CD2   1 
ATOM   6179  N  NE1   . TRP B 1 296 ? 128.759 140.471 85.211  1.00 139.46 ? 288 TRP B NE1   1 
ATOM   6180  C  CE2   . TRP B 1 296 ? 129.453 139.690 84.326  1.00 140.66 ? 288 TRP B CE2   1 
ATOM   6181  C  CE3   . TRP B 1 296 ? 129.104 138.708 82.146  1.00 135.82 ? 288 TRP B CE3   1 
ATOM   6182  C  CZ2   . TRP B 1 296 ? 130.734 139.152 84.416  1.00 141.74 ? 288 TRP B CZ2   1 
ATOM   6183  C  CZ3   . TRP B 1 296 ? 130.376 138.174 82.238  1.00 135.50 ? 288 TRP B CZ3   1 
ATOM   6184  C  CH2   . TRP B 1 296 ? 131.176 138.398 83.364  1.00 139.54 ? 288 TRP B CH2   1 
ATOM   6185  N  N     . PRO B 1 297 ? 125.742 142.089 79.837  1.00 128.19 ? 289 PRO B N     1 
ATOM   6186  C  CA    . PRO B 1 297 ? 125.108 142.136 78.516  1.00 125.52 ? 289 PRO B CA    1 
ATOM   6187  C  C     . PRO B 1 297 ? 124.605 140.765 78.089  1.00 123.18 ? 289 PRO B C     1 
ATOM   6188  O  O     . PRO B 1 297 ? 125.202 139.733 78.402  1.00 122.90 ? 289 PRO B O     1 
ATOM   6189  C  CB    . PRO B 1 297 ? 126.232 142.630 77.599  1.00 127.31 ? 289 PRO B CB    1 
ATOM   6190  C  CG    . PRO B 1 297 ? 127.194 143.320 78.510  1.00 129.32 ? 289 PRO B CG    1 
ATOM   6191  C  CD    . PRO B 1 297 ? 127.135 142.563 79.801  1.00 131.24 ? 289 PRO B CD    1 
ATOM   6192  N  N     . ALA B 1 298 ? 123.490 140.767 77.365  1.00 122.04 ? 290 ALA B N     1 
ATOM   6193  C  CA    . ALA B 1 298 ? 122.868 139.530 76.916  1.00 119.71 ? 290 ALA B CA    1 
ATOM   6194  C  C     . ALA B 1 298 ? 122.040 139.823 75.673  1.00 117.94 ? 290 ALA B C     1 
ATOM   6195  O  O     . ALA B 1 298 ? 121.749 140.978 75.352  1.00 117.25 ? 290 ALA B O     1 
ATOM   6196  C  CB    . ALA B 1 298 ? 122.004 138.907 78.016  1.00 119.87 ? 290 ALA B CB    1 
ATOM   6197  N  N     . LEU B 1 299 ? 121.665 138.755 74.975  1.00 115.77 ? 291 LEU B N     1 
ATOM   6198  C  CA    . LEU B 1 299 ? 120.844 138.856 73.776  1.00 114.95 ? 291 LEU B CA    1 
ATOM   6199  C  C     . LEU B 1 299 ? 119.378 138.717 74.165  1.00 113.33 ? 291 LEU B C     1 
ATOM   6200  O  O     . LEU B 1 299 ? 118.961 137.667 74.667  1.00 112.49 ? 291 LEU B O     1 
ATOM   6201  C  CB    . LEU B 1 299 ? 121.243 137.786 72.760  1.00 114.57 ? 291 LEU B CB    1 
ATOM   6202  C  CG    . LEU B 1 299 ? 120.526 137.787 71.409  1.00 113.68 ? 291 LEU B CG    1 
ATOM   6203  C  CD1   . LEU B 1 299 ? 121.512 137.487 70.294  1.00 111.25 ? 291 LEU B CD1   1 
ATOM   6204  C  CD2   . LEU B 1 299 ? 119.388 136.777 71.393  1.00 108.90 ? 291 LEU B CD2   1 
ATOM   6205  N  N     . GLY B 1 300 ? 118.599 139.768 73.922  1.00 113.10 ? 292 GLY B N     1 
ATOM   6206  C  CA    . GLY B 1 300 ? 117.201 139.752 74.321  1.00 112.62 ? 292 GLY B CA    1 
ATOM   6207  C  C     . GLY B 1 300 ? 117.072 139.654 75.827  1.00 113.45 ? 292 GLY B C     1 
ATOM   6208  O  O     . GLY B 1 300 ? 117.692 140.414 76.579  1.00 114.67 ? 292 GLY B O     1 
ATOM   6209  N  N     . ARG B 1 301 ? 116.255 138.705 76.283  1.00 111.52 ? 293 ARG B N     1 
ATOM   6210  C  CA    . ARG B 1 301 ? 116.107 138.458 77.711  1.00 108.70 ? 293 ARG B CA    1 
ATOM   6211  C  C     . ARG B 1 301 ? 117.260 137.656 78.295  1.00 108.68 ? 293 ARG B C     1 
ATOM   6212  O  O     . ARG B 1 301 ? 117.347 137.531 79.521  1.00 108.62 ? 293 ARG B O     1 
ATOM   6213  C  CB    . ARG B 1 301 ? 114.792 137.726 77.991  1.00 106.71 ? 293 ARG B CB    1 
ATOM   6214  C  CG    . ARG B 1 301 ? 113.544 138.545 77.717  1.00 112.78 ? 293 ARG B CG    1 
ATOM   6215  C  CD    . ARG B 1 301 ? 112.309 137.844 78.256  1.00 115.91 ? 293 ARG B CD    1 
ATOM   6216  N  NE    . ARG B 1 301 ? 111.107 138.654 78.105  1.00 120.33 ? 293 ARG B NE    1 
ATOM   6217  C  CZ    . ARG B 1 301 ? 110.258 138.555 77.091  1.00 124.74 ? 293 ARG B CZ    1 
ATOM   6218  N  NH1   . ARG B 1 301 ? 110.447 137.683 76.114  1.00 125.84 ? 293 ARG B NH1   1 
ATOM   6219  N  NH2   . ARG B 1 301 ? 109.191 139.348 77.058  1.00 123.01 ? 293 ARG B NH2   1 
ATOM   6220  N  N     . GLY B 1 302 ? 118.144 137.120 77.458  1.00 108.51 ? 294 GLY B N     1 
ATOM   6221  C  CA    . GLY B 1 302 ? 119.194 136.235 77.912  1.00 104.89 ? 294 GLY B CA    1 
ATOM   6222  C  C     . GLY B 1 302 ? 118.733 134.791 77.975  1.00 98.18  ? 294 GLY B C     1 
ATOM   6223  O  O     . GLY B 1 302 ? 117.560 134.462 77.791  1.00 96.79  ? 294 GLY B O     1 
ATOM   6224  N  N     . TYR B 1 303 ? 119.689 133.908 78.245  1.00 92.49  ? 295 TYR B N     1 
ATOM   6225  C  CA    . TYR B 1 303 ? 119.425 132.481 78.331  1.00 84.39  ? 295 TYR B CA    1 
ATOM   6226  C  C     . TYR B 1 303 ? 119.745 131.975 79.730  1.00 83.20  ? 295 TYR B C     1 
ATOM   6227  O  O     . TYR B 1 303 ? 120.665 132.463 80.392  1.00 86.48  ? 295 TYR B O     1 
ATOM   6228  C  CB    . TYR B 1 303 ? 120.234 131.702 77.290  1.00 78.40  ? 295 TYR B CB    1 
ATOM   6229  C  CG    . TYR B 1 303 ? 119.689 131.827 75.885  1.00 81.59  ? 295 TYR B CG    1 
ATOM   6230  C  CD1   . TYR B 1 303 ? 118.728 130.944 75.414  1.00 82.82  ? 295 TYR B CD1   1 
ATOM   6231  C  CD2   . TYR B 1 303 ? 120.131 132.830 75.033  1.00 86.03  ? 295 TYR B CD2   1 
ATOM   6232  C  CE1   . TYR B 1 303 ? 118.224 131.052 74.134  1.00 84.38  ? 295 TYR B CE1   1 
ATOM   6233  C  CE2   . TYR B 1 303 ? 119.632 132.946 73.749  1.00 85.04  ? 295 TYR B CE2   1 
ATOM   6234  C  CZ    . TYR B 1 303 ? 118.678 132.054 73.306  1.00 83.56  ? 295 TYR B CZ    1 
ATOM   6235  O  OH    . TYR B 1 303 ? 118.175 132.161 72.031  1.00 84.59  ? 295 TYR B OH    1 
ATOM   6236  N  N     . ASN B 1 304 ? 118.972 130.989 80.172  1.00 80.10  ? 296 ASN B N     1 
ATOM   6237  C  CA    . ASN B 1 304 ? 119.088 130.436 81.514  1.00 77.32  ? 296 ASN B CA    1 
ATOM   6238  C  C     . ASN B 1 304 ? 119.931 129.169 81.479  1.00 72.09  ? 296 ASN B C     1 
ATOM   6239  O  O     . ASN B 1 304 ? 119.688 128.276 80.660  1.00 70.35  ? 296 ASN B O     1 
ATOM   6240  C  CB    . ASN B 1 304 ? 117.707 130.139 82.095  1.00 75.00  ? 296 ASN B CB    1 
ATOM   6241  C  CG    . ASN B 1 304 ? 117.774 129.565 83.492  1.00 71.57  ? 296 ASN B CG    1 
ATOM   6242  O  OD1   . ASN B 1 304 ? 117.663 128.355 83.683  1.00 70.91  ? 296 ASN B OD1   1 
ATOM   6243  N  ND2   . ASN B 1 304 ? 117.956 130.432 84.480  1.00 72.95  ? 296 ASN B ND2   1 
ATOM   6244  N  N     . THR B 1 305 ? 120.915 129.091 82.374  1.00 71.19  ? 297 THR B N     1 
ATOM   6245  C  CA    . THR B 1 305 ? 121.831 127.963 82.439  1.00 68.07  ? 297 THR B CA    1 
ATOM   6246  C  C     . THR B 1 305 ? 121.335 126.850 83.356  1.00 66.91  ? 297 THR B C     1 
ATOM   6247  O  O     . THR B 1 305 ? 122.124 125.980 83.740  1.00 70.15  ? 297 THR B O     1 
ATOM   6248  C  CB    . THR B 1 305 ? 123.215 128.434 82.889  1.00 77.68  ? 297 THR B CB    1 
ATOM   6249  O  OG1   . THR B 1 305 ? 123.114 129.060 84.173  1.00 86.74  ? 297 THR B OG1   1 
ATOM   6250  C  CG2   . THR B 1 305 ? 123.781 129.429 81.893  1.00 85.34  ? 297 THR B CG2   1 
ATOM   6251  N  N     . GLY B 1 306 ? 120.053 126.865 83.723  1.00 63.36  ? 298 GLY B N     1 
ATOM   6252  C  CA    . GLY B 1 306 ? 119.517 125.781 84.529  1.00 55.17  ? 298 GLY B CA    1 
ATOM   6253  C  C     . GLY B 1 306 ? 119.568 124.446 83.813  1.00 57.59  ? 298 GLY B C     1 
ATOM   6254  O  O     . GLY B 1 306 ? 119.887 123.419 84.415  1.00 60.92  ? 298 GLY B O     1 
ATOM   6255  N  N     . VAL B 1 307 ? 119.248 124.441 82.521  1.00 59.36  ? 299 VAL B N     1 
ATOM   6256  C  CA    . VAL B 1 307 ? 119.350 123.256 81.679  1.00 49.73  ? 299 VAL B CA    1 
ATOM   6257  C  C     . VAL B 1 307 ? 120.156 123.627 80.445  1.00 52.84  ? 299 VAL B C     1 
ATOM   6258  O  O     . VAL B 1 307 ? 119.816 124.586 79.745  1.00 56.40  ? 299 VAL B O     1 
ATOM   6259  C  CB    . VAL B 1 307 ? 117.966 122.711 81.278  1.00 46.96  ? 299 VAL B CB    1 
ATOM   6260  C  CG1   . VAL B 1 307 ? 118.115 121.555 80.309  1.00 49.17  ? 299 VAL B CG1   1 
ATOM   6261  C  CG2   . VAL B 1 307 ? 117.190 122.279 82.508  1.00 50.60  ? 299 VAL B CG2   1 
ATOM   6262  N  N     . ILE B 1 308 ? 121.220 122.873 80.180  1.00 50.55  ? 300 ILE B N     1 
ATOM   6263  C  CA    . ILE B 1 308 ? 122.116 123.134 79.061  1.00 48.47  ? 300 ILE B CA    1 
ATOM   6264  C  C     . ILE B 1 308 ? 122.265 121.854 78.255  1.00 51.68  ? 300 ILE B C     1 
ATOM   6265  O  O     . ILE B 1 308 ? 122.320 120.760 78.823  1.00 57.39  ? 300 ILE B O     1 
ATOM   6266  C  CB    . ILE B 1 308 ? 123.495 123.634 79.543  1.00 46.42  ? 300 ILE B CB    1 
ATOM   6267  C  CG1   . ILE B 1 308 ? 123.341 124.848 80.458  1.00 50.81  ? 300 ILE B CG1   1 
ATOM   6268  C  CG2   . ILE B 1 308 ? 124.390 123.973 78.365  1.00 48.47  ? 300 ILE B CG2   1 
ATOM   6269  C  CD1   . ILE B 1 308 ? 124.655 125.458 80.881  1.00 56.56  ? 300 ILE B CD1   1 
ATOM   6270  N  N     . LEU B 1 309 ? 122.318 121.986 76.934  1.00 51.21  ? 301 LEU B N     1 
ATOM   6271  C  CA    . LEU B 1 309 ? 122.686 120.888 76.049  1.00 54.59  ? 301 LEU B CA    1 
ATOM   6272  C  C     . LEU B 1 309 ? 124.024 121.231 75.410  1.00 60.01  ? 301 LEU B C     1 
ATOM   6273  O  O     . LEU B 1 309 ? 124.156 122.282 74.776  1.00 66.15  ? 301 LEU B O     1 
ATOM   6274  C  CB    . LEU B 1 309 ? 121.620 120.650 74.980  1.00 59.10  ? 301 LEU B CB    1 
ATOM   6275  C  CG    . LEU B 1 309 ? 120.224 120.266 75.467  1.00 54.69  ? 301 LEU B CG    1 
ATOM   6276  C  CD1   . LEU B 1 309 ? 119.381 119.756 74.311  1.00 59.37  ? 301 LEU B CD1   1 
ATOM   6277  C  CD2   . LEU B 1 309 ? 120.303 119.231 76.568  1.00 48.35  ? 301 LEU B CD2   1 
ATOM   6278  N  N     . LEU B 1 310 ? 125.012 120.355 75.579  1.00 61.40  ? 302 LEU B N     1 
ATOM   6279  C  CA    . LEU B 1 310 ? 126.364 120.610 75.105  1.00 63.90  ? 302 LEU B CA    1 
ATOM   6280  C  C     . LEU B 1 310 ? 126.785 119.530 74.123  1.00 70.32  ? 302 LEU B C     1 
ATOM   6281  O  O     . LEU B 1 310 ? 126.521 118.343 74.345  1.00 72.09  ? 302 LEU B O     1 
ATOM   6282  C  CB    . LEU B 1 310 ? 127.361 120.666 76.265  1.00 62.03  ? 302 LEU B CB    1 
ATOM   6283  C  CG    . LEU B 1 310 ? 127.306 121.878 77.191  1.00 66.09  ? 302 LEU B CG    1 
ATOM   6284  C  CD1   . LEU B 1 310 ? 128.431 121.819 78.210  1.00 71.01  ? 302 LEU B CD1   1 
ATOM   6285  C  CD2   . LEU B 1 310 ? 127.385 123.154 76.385  1.00 67.92  ? 302 LEU B CD2   1 
ATOM   6286  N  N     . LEU B 1 311 ? 127.435 119.948 73.040  1.00 76.90  ? 303 LEU B N     1 
ATOM   6287  C  CA    . LEU B 1 311 ? 128.141 119.047 72.135  1.00 80.02  ? 303 LEU B CA    1 
ATOM   6288  C  C     . LEU B 1 311 ? 129.627 119.229 72.421  1.00 90.25  ? 303 LEU B C     1 
ATOM   6289  O  O     . LEU B 1 311 ? 130.248 120.188 71.956  1.00 93.33  ? 303 LEU B O     1 
ATOM   6290  C  CB    . LEU B 1 311 ? 127.801 119.340 70.677  1.00 79.62  ? 303 LEU B CB    1 
ATOM   6291  C  CG    . LEU B 1 311 ? 126.419 118.908 70.178  1.00 76.91  ? 303 LEU B CG    1 
ATOM   6292  C  CD1   . LEU B 1 311 ? 125.338 119.884 70.612  1.00 76.02  ? 303 LEU B CD1   1 
ATOM   6293  C  CD2   . LEU B 1 311 ? 126.420 118.746 68.667  1.00 80.17  ? 303 LEU B CD2   1 
ATOM   6294  N  N     . LEU B 1 312 ? 130.192 118.306 73.204  1.00 88.44  ? 304 LEU B N     1 
ATOM   6295  C  CA    . LEU B 1 312 ? 131.556 118.475 73.695  1.00 89.20  ? 304 LEU B CA    1 
ATOM   6296  C  C     . LEU B 1 312 ? 132.569 118.467 72.557  1.00 98.33  ? 304 LEU B C     1 
ATOM   6297  O  O     . LEU B 1 312 ? 133.546 119.225 72.583  1.00 102.26 ? 304 LEU B O     1 
ATOM   6298  C  CB    . LEU B 1 312 ? 131.884 117.382 74.710  1.00 84.70  ? 304 LEU B CB    1 
ATOM   6299  C  CG    . LEU B 1 312 ? 131.039 117.374 75.983  1.00 82.19  ? 304 LEU B CG    1 
ATOM   6300  C  CD1   . LEU B 1 312 ? 131.456 116.230 76.890  1.00 83.45  ? 304 LEU B CD1   1 
ATOM   6301  C  CD2   . LEU B 1 312 ? 131.156 118.704 76.706  1.00 82.92  ? 304 LEU B CD2   1 
ATOM   6302  N  N     . ASP B 1 313 ? 132.361 117.608 71.557  1.00 97.72  ? 305 ASP B N     1 
ATOM   6303  C  CA    . ASP B 1 313 ? 133.317 117.503 70.460  1.00 98.06  ? 305 ASP B CA    1 
ATOM   6304  C  C     . ASP B 1 313 ? 133.443 118.824 69.708  1.00 104.74 ? 305 ASP B C     1 
ATOM   6305  O  O     . ASP B 1 313 ? 134.554 119.292 69.432  1.00 109.50 ? 305 ASP B O     1 
ATOM   6306  C  CB    . ASP B 1 313 ? 132.900 116.377 69.514  1.00 96.87  ? 305 ASP B CB    1 
ATOM   6307  C  CG    . ASP B 1 313 ? 131.440 116.462 69.117  1.00 96.84  ? 305 ASP B CG    1 
ATOM   6308  O  OD1   . ASP B 1 313 ? 130.640 117.003 69.908  1.00 95.06  ? 305 ASP B OD1   1 
ATOM   6309  O  OD2   . ASP B 1 313 ? 131.091 115.989 68.016  1.00 97.78  ? 305 ASP B OD2   1 
ATOM   6310  N  N     . LYS B 1 314 ? 132.310 119.449 69.384  1.00 100.67 ? 306 LYS B N     1 
ATOM   6311  C  CA    . LYS B 1 314 ? 132.351 120.704 68.642  1.00 99.15  ? 306 LYS B CA    1 
ATOM   6312  C  C     . LYS B 1 314 ? 132.925 121.834 69.489  1.00 102.91 ? 306 LYS B C     1 
ATOM   6313  O  O     . LYS B 1 314 ? 133.644 122.697 68.974  1.00 107.61 ? 306 LYS B O     1 
ATOM   6314  C  CB    . LYS B 1 314 ? 130.955 121.059 68.134  1.00 92.47  ? 306 LYS B CB    1 
ATOM   6315  C  CG    . LYS B 1 314 ? 130.393 120.050 67.146  1.00 94.17  ? 306 LYS B CG    1 
ATOM   6316  C  CD    . LYS B 1 314 ? 129.055 120.500 66.588  1.00 96.36  ? 306 LYS B CD    1 
ATOM   6317  C  CE    . LYS B 1 314 ? 128.507 119.491 65.592  1.00 95.66  ? 306 LYS B CE    1 
ATOM   6318  N  NZ    . LYS B 1 314 ? 127.200 119.922 65.026  1.00 91.26  ? 306 LYS B NZ    1 
ATOM   6319  N  N     . LEU B 1 315 ? 132.617 121.849 70.788  1.00 100.68 ? 307 LEU B N     1 
ATOM   6320  C  CA    . LEU B 1 315 ? 133.196 122.859 71.668  1.00 102.28 ? 307 LEU B CA    1 
ATOM   6321  C  C     . LEU B 1 315 ? 134.710 122.720 71.742  1.00 107.61 ? 307 LEU B C     1 
ATOM   6322  O  O     . LEU B 1 315 ? 135.436 123.722 71.731  1.00 110.10 ? 307 LEU B O     1 
ATOM   6323  C  CB    . LEU B 1 315 ? 132.583 122.759 73.064  1.00 97.80  ? 307 LEU B CB    1 
ATOM   6324  C  CG    . LEU B 1 315 ? 131.141 123.238 73.213  1.00 97.71  ? 307 LEU B CG    1 
ATOM   6325  C  CD1   . LEU B 1 315 ? 130.660 123.040 74.638  1.00 92.88  ? 307 LEU B CD1   1 
ATOM   6326  C  CD2   . LEU B 1 315 ? 131.033 124.695 72.811  1.00 100.93 ? 307 LEU B CD2   1 
ATOM   6327  N  N     . ARG B 1 316 ? 135.206 121.484 71.827  1.00 108.12 ? 308 ARG B N     1 
ATOM   6328  C  CA    . ARG B 1 316 ? 136.647 121.263 71.855  1.00 106.76 ? 308 ARG B CA    1 
ATOM   6329  C  C     . ARG B 1 316 ? 137.291 121.638 70.526  1.00 113.44 ? 308 ARG B C     1 
ATOM   6330  O  O     . ARG B 1 316 ? 138.405 122.173 70.499  1.00 115.40 ? 308 ARG B O     1 
ATOM   6331  C  CB    . ARG B 1 316 ? 136.944 119.807 72.212  1.00 101.83 ? 308 ARG B CB    1 
ATOM   6332  C  CG    . ARG B 1 316 ? 136.605 119.451 73.650  1.00 99.34  ? 308 ARG B CG    1 
ATOM   6333  C  CD    . ARG B 1 316 ? 136.334 117.965 73.805  1.00 94.63  ? 308 ARG B CD    1 
ATOM   6334  N  NE    . ARG B 1 316 ? 135.995 117.616 75.179  1.00 93.99  ? 308 ARG B NE    1 
ATOM   6335  C  CZ    . ARG B 1 316 ? 135.426 116.475 75.541  1.00 91.76  ? 308 ARG B CZ    1 
ATOM   6336  N  NH1   . ARG B 1 316 ? 135.097 115.554 74.650  1.00 92.78  ? 308 ARG B NH1   1 
ATOM   6337  N  NH2   . ARG B 1 316 ? 135.175 116.254 76.828  1.00 86.85  ? 308 ARG B NH2   1 
ATOM   6338  N  N     . LYS B 1 317 ? 136.606 121.363 69.413  1.00 115.29 ? 309 LYS B N     1 
ATOM   6339  C  CA    . LYS B 1 317 ? 137.146 121.735 68.109  1.00 112.99 ? 309 LYS B CA    1 
ATOM   6340  C  C     . LYS B 1 317 ? 137.206 123.247 67.930  1.00 113.09 ? 309 LYS B C     1 
ATOM   6341  O  O     . LYS B 1 317 ? 138.074 123.748 67.206  1.00 115.04 ? 309 LYS B O     1 
ATOM   6342  C  CB    . LYS B 1 317 ? 136.312 121.103 66.994  1.00 109.12 ? 309 LYS B CB    1 
ATOM   6343  C  CG    . LYS B 1 317 ? 136.435 119.593 66.910  1.00 109.63 ? 309 LYS B CG    1 
ATOM   6344  C  CD    . LYS B 1 317 ? 135.491 119.020 65.868  1.00 110.16 ? 309 LYS B CD    1 
ATOM   6345  C  CE    . LYS B 1 317 ? 135.571 117.503 65.828  1.00 113.26 ? 309 LYS B CE    1 
ATOM   6346  N  NZ    . LYS B 1 317 ? 134.630 116.924 64.831  1.00 116.10 ? 309 LYS B NZ    1 
ATOM   6347  N  N     . MET B 1 318 ? 136.306 123.985 68.573  1.00 113.12 ? 310 MET B N     1 
ATOM   6348  C  CA    . MET B 1 318 ? 136.249 125.434 68.435  1.00 114.51 ? 310 MET B CA    1 
ATOM   6349  C  C     . MET B 1 318 ? 137.012 126.173 69.526  1.00 114.50 ? 310 MET B C     1 
ATOM   6350  O  O     . MET B 1 318 ? 136.958 127.407 69.566  1.00 112.95 ? 310 MET B O     1 
ATOM   6351  C  CB    . MET B 1 318 ? 134.791 125.906 68.424  1.00 115.68 ? 310 MET B CB    1 
ATOM   6352  C  CG    . MET B 1 318 ? 133.978 125.374 67.257  1.00 117.78 ? 310 MET B CG    1 
ATOM   6353  S  SD    . MET B 1 318 ? 132.330 126.098 67.180  1.00 126.35 ? 310 MET B SD    1 
ATOM   6354  C  CE    . MET B 1 318 ? 132.736 127.821 66.907  1.00 121.96 ? 310 MET B CE    1 
ATOM   6355  N  N     . LYS B 1 319 ? 137.712 125.455 70.406  1.00 116.57 ? 311 LYS B N     1 
ATOM   6356  C  CA    . LYS B 1 319 ? 138.472 126.054 71.504  1.00 120.76 ? 311 LYS B CA    1 
ATOM   6357  C  C     . LYS B 1 319 ? 137.570 126.926 72.380  1.00 125.66 ? 311 LYS B C     1 
ATOM   6358  O  O     . LYS B 1 319 ? 137.746 128.140 72.496  1.00 127.75 ? 311 LYS B O     1 
ATOM   6359  C  CB    . LYS B 1 319 ? 139.670 126.850 70.974  1.00 119.83 ? 311 LYS B CB    1 
ATOM   6360  C  CG    . LYS B 1 319 ? 140.701 126.003 70.246  1.00 120.40 ? 311 LYS B CG    1 
ATOM   6361  C  CD    . LYS B 1 319 ? 141.907 126.832 69.835  1.00 123.22 ? 311 LYS B CD    1 
ATOM   6362  C  CE    . LYS B 1 319 ? 142.965 125.971 69.165  1.00 122.35 ? 311 LYS B CE    1 
ATOM   6363  N  NZ    . LYS B 1 319 ? 144.166 126.764 68.785  1.00 122.59 ? 311 LYS B NZ    1 
ATOM   6364  N  N     . TRP B 1 320 ? 136.583 126.270 72.998  1.00 122.63 ? 312 TRP B N     1 
ATOM   6365  C  CA    . TRP B 1 320 ? 135.632 126.982 73.845  1.00 119.87 ? 312 TRP B CA    1 
ATOM   6366  C  C     . TRP B 1 320 ? 136.308 127.599 75.061  1.00 122.68 ? 312 TRP B C     1 
ATOM   6367  O  O     . TRP B 1 320 ? 135.874 128.654 75.543  1.00 125.81 ? 312 TRP B O     1 
ATOM   6368  C  CB    . TRP B 1 320 ? 134.513 126.035 74.281  1.00 112.84 ? 312 TRP B CB    1 
ATOM   6369  C  CG    . TRP B 1 320 ? 133.617 126.607 75.335  1.00 115.59 ? 312 TRP B CG    1 
ATOM   6370  C  CD1   . TRP B 1 320 ? 133.732 126.443 76.685  1.00 114.21 ? 312 TRP B CD1   1 
ATOM   6371  C  CD2   . TRP B 1 320 ? 132.469 127.438 75.128  1.00 114.53 ? 312 TRP B CD2   1 
ATOM   6372  N  NE1   . TRP B 1 320 ? 132.727 127.119 77.331  1.00 113.25 ? 312 TRP B NE1   1 
ATOM   6373  C  CE2   . TRP B 1 320 ? 131.937 127.738 76.398  1.00 113.31 ? 312 TRP B CE2   1 
ATOM   6374  C  CE3   . TRP B 1 320 ? 131.839 127.956 73.994  1.00 109.95 ? 312 TRP B CE3   1 
ATOM   6375  C  CZ2   . TRP B 1 320 ? 130.806 128.532 76.564  1.00 108.54 ? 312 TRP B CZ2   1 
ATOM   6376  C  CZ3   . TRP B 1 320 ? 130.716 128.744 74.161  1.00 110.04 ? 312 TRP B CZ3   1 
ATOM   6377  C  CH2   . TRP B 1 320 ? 130.212 129.025 75.436  1.00 107.54 ? 312 TRP B CH2   1 
ATOM   6378  N  N     . GLU B 1 321 ? 137.362 126.958 75.572  1.00 121.17 ? 313 GLU B N     1 
ATOM   6379  C  CA    . GLU B 1 321 ? 138.039 127.465 76.761  1.00 122.86 ? 313 GLU B CA    1 
ATOM   6380  C  C     . GLU B 1 321 ? 138.569 128.875 76.533  1.00 126.15 ? 313 GLU B C     1 
ATOM   6381  O  O     . GLU B 1 321 ? 138.281 129.793 77.310  1.00 126.59 ? 313 GLU B O     1 
ATOM   6382  C  CB    . GLU B 1 321 ? 139.174 126.521 77.161  1.00 121.34 ? 313 GLU B CB    1 
ATOM   6383  C  CG    . GLU B 1 321 ? 138.718 125.127 77.562  1.00 122.73 ? 313 GLU B CG    1 
ATOM   6384  C  CD    . GLU B 1 321 ? 138.014 125.103 78.905  1.00 120.77 ? 313 GLU B CD    1 
ATOM   6385  O  OE1   . GLU B 1 321 ? 138.187 126.060 79.690  1.00 121.40 ? 313 GLU B OE1   1 
ATOM   6386  O  OE2   . GLU B 1 321 ? 137.286 124.124 79.178  1.00 113.98 ? 313 GLU B OE2   1 
ATOM   6387  N  N     . GLN B 1 322 ? 139.334 129.066 75.455  1.00 127.61 ? 314 GLN B N     1 
ATOM   6388  C  CA    . GLN B 1 322 ? 139.894 130.380 75.163  1.00 127.71 ? 314 GLN B CA    1 
ATOM   6389  C  C     . GLN B 1 322 ? 138.795 131.400 74.896  1.00 130.59 ? 314 GLN B C     1 
ATOM   6390  O  O     . GLN B 1 322 ? 138.881 132.549 75.345  1.00 133.50 ? 314 GLN B O     1 
ATOM   6391  C  CB    . GLN B 1 322 ? 140.842 130.288 73.968  1.00 125.88 ? 314 GLN B CB    1 
ATOM   6392  C  CG    . GLN B 1 322 ? 141.912 129.219 74.109  1.00 127.58 ? 314 GLN B CG    1 
ATOM   6393  C  CD    . GLN B 1 322 ? 142.751 129.065 72.856  1.00 127.84 ? 314 GLN B CD    1 
ATOM   6394  O  OE1   . GLN B 1 322 ? 142.582 129.805 71.887  1.00 129.52 ? 314 GLN B OE1   1 
ATOM   6395  N  NE2   . GLN B 1 322 ? 143.661 128.098 72.869  1.00 125.36 ? 314 GLN B NE2   1 
ATOM   6396  N  N     . MET B 1 323 ? 137.753 130.994 74.167  1.00 130.00 ? 315 MET B N     1 
ATOM   6397  C  CA    . MET B 1 323 ? 136.660 131.908 73.850  1.00 130.55 ? 315 MET B CA    1 
ATOM   6398  C  C     . MET B 1 323 ? 135.997 132.435 75.116  1.00 132.16 ? 315 MET B C     1 
ATOM   6399  O  O     . MET B 1 323 ? 135.868 133.653 75.305  1.00 133.18 ? 315 MET B O     1 
ATOM   6400  C  CB    . MET B 1 323 ? 135.634 131.203 72.962  1.00 125.85 ? 315 MET B CB    1 
ATOM   6401  C  CG    . MET B 1 323 ? 134.419 132.047 72.621  1.00 126.25 ? 315 MET B CG    1 
ATOM   6402  S  SD    . MET B 1 323 ? 133.057 131.068 71.958  1.00 124.86 ? 315 MET B SD    1 
ATOM   6403  C  CE    . MET B 1 323 ? 133.873 130.208 70.617  1.00 122.99 ? 315 MET B CE    1 
ATOM   6404  N  N     . TRP B 1 324 ? 135.584 131.529 76.009  1.00 129.31 ? 316 TRP B N     1 
ATOM   6405  C  CA    . TRP B 1 324 ? 134.897 131.985 77.212  1.00 127.44 ? 316 TRP B CA    1 
ATOM   6406  C  C     . TRP B 1 324 ? 135.844 132.720 78.149  1.00 131.93 ? 316 TRP B C     1 
ATOM   6407  O  O     . TRP B 1 324 ? 135.423 133.668 78.817  1.00 134.55 ? 316 TRP B O     1 
ATOM   6408  C  CB    . TRP B 1 324 ? 134.205 130.818 77.930  1.00 123.72 ? 316 TRP B CB    1 
ATOM   6409  C  CG    . TRP B 1 324 ? 135.069 130.004 78.851  1.00 122.96 ? 316 TRP B CG    1 
ATOM   6410  C  CD1   . TRP B 1 324 ? 135.599 128.778 78.594  1.00 122.22 ? 316 TRP B CD1   1 
ATOM   6411  C  CD2   . TRP B 1 324 ? 135.474 130.343 80.186  1.00 124.16 ? 316 TRP B CD2   1 
ATOM   6412  N  NE1   . TRP B 1 324 ? 136.324 128.336 79.674  1.00 124.17 ? 316 TRP B NE1   1 
ATOM   6413  C  CE2   . TRP B 1 324 ? 136.263 129.280 80.665  1.00 124.50 ? 316 TRP B CE2   1 
ATOM   6414  C  CE3   . TRP B 1 324 ? 135.254 131.446 81.018  1.00 127.13 ? 316 TRP B CE3   1 
ATOM   6415  C  CZ2   . TRP B 1 324 ? 136.831 129.286 81.936  1.00 126.10 ? 316 TRP B CZ2   1 
ATOM   6416  C  CZ3   . TRP B 1 324 ? 135.822 131.451 82.278  1.00 130.58 ? 316 TRP B CZ3   1 
ATOM   6417  C  CH2   . TRP B 1 324 ? 136.600 130.378 82.725  1.00 128.97 ? 316 TRP B CH2   1 
ATOM   6418  N  N     . ARG B 1 325 ? 137.119 132.320 78.211  1.00 133.36 ? 317 ARG B N     1 
ATOM   6419  C  CA    . ARG B 1 325 ? 138.065 133.037 79.060  1.00 135.07 ? 317 ARG B CA    1 
ATOM   6420  C  C     . ARG B 1 325 ? 138.238 134.476 78.592  1.00 138.21 ? 317 ARG B C     1 
ATOM   6421  O  O     . ARG B 1 325 ? 138.198 135.413 79.399  1.00 138.98 ? 317 ARG B O     1 
ATOM   6422  C  CB    . ARG B 1 325 ? 139.412 132.312 79.082  1.00 133.65 ? 317 ARG B CB    1 
ATOM   6423  C  CG    . ARG B 1 325 ? 139.443 131.078 79.968  1.00 131.51 ? 317 ARG B CG    1 
ATOM   6424  C  CD    . ARG B 1 325 ? 140.821 130.438 79.970  1.00 129.59 ? 317 ARG B CD    1 
ATOM   6425  N  NE    . ARG B 1 325 ? 140.876 129.262 80.830  1.00 129.98 ? 317 ARG B NE    1 
ATOM   6426  C  CZ    . ARG B 1 325 ? 141.172 129.292 82.121  1.00 134.85 ? 317 ARG B CZ    1 
ATOM   6427  N  NH1   . ARG B 1 325 ? 141.445 130.429 82.742  1.00 135.66 ? 317 ARG B NH1   1 
ATOM   6428  N  NH2   . ARG B 1 325 ? 141.197 128.154 82.808  1.00 134.65 ? 317 ARG B NH2   1 
ATOM   6429  N  N     . LEU B 1 326 ? 138.422 134.673 77.284  1.00 137.87 ? 318 LEU B N     1 
ATOM   6430  C  CA    . LEU B 1 326 ? 138.574 136.025 76.758  1.00 138.91 ? 318 LEU B CA    1 
ATOM   6431  C  C     . LEU B 1 326 ? 137.305 136.841 76.958  1.00 139.74 ? 318 LEU B C     1 
ATOM   6432  O  O     . LEU B 1 326 ? 137.369 138.021 77.327  1.00 142.56 ? 318 LEU B O     1 
ATOM   6433  C  CB    . LEU B 1 326 ? 138.956 135.977 75.279  1.00 138.74 ? 318 LEU B CB    1 
ATOM   6434  C  CG    . LEU B 1 326 ? 140.356 135.445 74.963  1.00 142.52 ? 318 LEU B CG    1 
ATOM   6435  C  CD1   . LEU B 1 326 ? 140.622 135.485 73.466  1.00 141.75 ? 318 LEU B CD1   1 
ATOM   6436  C  CD2   . LEU B 1 326 ? 141.414 136.233 75.721  1.00 143.25 ? 318 LEU B CD2   1 
ATOM   6437  N  N     . THR B 1 327 ? 136.138 136.230 76.725  1.00 137.46 ? 319 THR B N     1 
ATOM   6438  C  CA    . THR B 1 327 ? 134.885 136.955 76.914  1.00 135.60 ? 319 THR B CA    1 
ATOM   6439  C  C     . THR B 1 327 ? 134.702 137.370 78.369  1.00 138.06 ? 319 THR B C     1 
ATOM   6440  O  O     . THR B 1 327 ? 134.313 138.510 78.656  1.00 138.28 ? 319 THR B O     1 
ATOM   6441  C  CB    . THR B 1 327 ? 133.710 136.098 76.448  1.00 130.77 ? 319 THR B CB    1 
ATOM   6442  O  OG1   . THR B 1 327 ? 133.969 135.609 75.127  1.00 132.89 ? 319 THR B OG1   1 
ATOM   6443  C  CG2   . THR B 1 327 ? 132.434 136.918 76.432  1.00 123.92 ? 319 THR B CG2   1 
ATOM   6444  N  N     . ALA B 1 328 ? 134.991 136.460 79.303  1.00 140.60 ? 320 ALA B N     1 
ATOM   6445  C  CA    . ALA B 1 328 ? 134.856 136.773 80.720  1.00 143.14 ? 320 ALA B CA    1 
ATOM   6446  C  C     . ALA B 1 328 ? 135.834 137.858 81.143  1.00 145.95 ? 320 ALA B C     1 
ATOM   6447  O  O     . ALA B 1 328 ? 135.473 138.754 81.912  1.00 147.90 ? 320 ALA B O     1 
ATOM   6448  C  CB    . ALA B 1 328 ? 135.056 135.511 81.558  1.00 140.93 ? 320 ALA B CB    1 
ATOM   6449  N  N     . GLU B 1 329 ? 137.077 137.797 80.657  1.00 144.41 ? 321 GLU B N     1 
ATOM   6450  C  CA    . GLU B 1 329 ? 138.043 138.838 80.992  1.00 143.41 ? 321 GLU B CA    1 
ATOM   6451  C  C     . GLU B 1 329 ? 137.596 140.194 80.462  1.00 145.65 ? 321 GLU B C     1 
ATOM   6452  O  O     . GLU B 1 329 ? 137.661 141.202 81.178  1.00 147.93 ? 321 GLU B O     1 
ATOM   6453  C  CB    . GLU B 1 329 ? 139.423 138.473 80.445  1.00 141.40 ? 321 GLU B CB    1 
ATOM   6454  C  CG    . GLU B 1 329 ? 140.078 137.298 81.151  1.00 141.89 ? 321 GLU B CG    1 
ATOM   6455  C  CD    . GLU B 1 329 ? 141.425 136.937 80.559  1.00 144.09 ? 321 GLU B CD    1 
ATOM   6456  O  OE1   . GLU B 1 329 ? 141.847 137.602 79.590  1.00 146.22 ? 321 GLU B OE1   1 
ATOM   6457  O  OE2   . GLU B 1 329 ? 142.062 135.988 81.062  1.00 143.90 ? 321 GLU B OE2   1 
ATOM   6458  N  N     . ARG B 1 330 ? 137.122 140.236 79.213  1.00 145.24 ? 322 ARG B N     1 
ATOM   6459  C  CA    . ARG B 1 330 ? 136.675 141.501 78.640  1.00 146.60 ? 322 ARG B CA    1 
ATOM   6460  C  C     . ARG B 1 330 ? 135.487 142.064 79.407  1.00 148.55 ? 322 ARG B C     1 
ATOM   6461  O  O     . ARG B 1 330 ? 135.414 143.274 79.653  1.00 150.45 ? 322 ARG B O     1 
ATOM   6462  C  CB    . ARG B 1 330 ? 136.321 141.320 77.165  1.00 142.97 ? 322 ARG B CB    1 
ATOM   6463  C  CG    . ARG B 1 330 ? 136.058 142.630 76.439  1.00 141.19 ? 322 ARG B CG    1 
ATOM   6464  C  CD    . ARG B 1 330 ? 135.462 142.399 75.062  1.00 140.55 ? 322 ARG B CD    1 
ATOM   6465  N  NE    . ARG B 1 330 ? 134.115 141.847 75.137  1.00 138.97 ? 322 ARG B NE    1 
ATOM   6466  C  CZ    . ARG B 1 330 ? 133.327 141.653 74.089  1.00 137.76 ? 322 ARG B CZ    1 
ATOM   6467  N  NH1   . ARG B 1 330 ? 133.720 141.956 72.863  1.00 141.08 ? 322 ARG B NH1   1 
ATOM   6468  N  NH2   . ARG B 1 330 ? 132.114 141.141 74.276  1.00 133.07 ? 322 ARG B NH2   1 
ATOM   6469  N  N     . GLU B 1 331 ? 134.539 141.204 79.790  1.00 147.06 ? 323 GLU B N     1 
ATOM   6470  C  CA    . GLU B 1 331 ? 133.388 141.678 80.551  1.00 146.44 ? 323 GLU B CA    1 
ATOM   6471  C  C     . GLU B 1 331 ? 133.796 142.157 81.940  1.00 149.85 ? 323 GLU B C     1 
ATOM   6472  O  O     . GLU B 1 331 ? 133.302 143.186 82.416  1.00 149.61 ? 323 GLU B O     1 
ATOM   6473  C  CB    . GLU B 1 331 ? 132.333 140.578 80.649  1.00 142.72 ? 323 GLU B CB    1 
ATOM   6474  C  CG    . GLU B 1 331 ? 131.660 140.246 79.327  1.00 140.29 ? 323 GLU B CG    1 
ATOM   6475  C  CD    . GLU B 1 331 ? 130.736 141.348 78.844  1.00 140.64 ? 323 GLU B CD    1 
ATOM   6476  O  OE1   . GLU B 1 331 ? 130.366 142.220 79.658  1.00 139.58 ? 323 GLU B OE1   1 
ATOM   6477  O  OE2   . GLU B 1 331 ? 130.379 141.340 77.647  1.00 142.41 ? 323 GLU B OE2   1 
ATOM   6478  N  N     . LEU B 1 332 ? 134.700 141.432 82.604  1.00 152.59 ? 324 LEU B N     1 
ATOM   6479  C  CA    . LEU B 1 332 ? 135.121 141.808 83.947  1.00 154.64 ? 324 LEU B CA    1 
ATOM   6480  C  C     . LEU B 1 332 ? 136.022 143.034 83.953  1.00 155.52 ? 324 LEU B C     1 
ATOM   6481  O  O     . LEU B 1 332 ? 136.208 143.640 85.013  1.00 156.61 ? 324 LEU B O     1 
ATOM   6482  C  CB    . LEU B 1 332 ? 135.834 140.637 84.624  1.00 152.16 ? 324 LEU B CB    1 
ATOM   6483  C  CG    . LEU B 1 332 ? 134.949 139.459 85.035  1.00 149.72 ? 324 LEU B CG    1 
ATOM   6484  C  CD1   . LEU B 1 332 ? 135.785 138.351 85.655  1.00 147.72 ? 324 LEU B CD1   1 
ATOM   6485  C  CD2   . LEU B 1 332 ? 133.864 139.918 85.996  1.00 149.45 ? 324 LEU B CD2   1 
ATOM   6486  N  N     . MET B 1 333 ? 136.594 143.405 82.804  1.00 155.08 ? 325 MET B N     1 
ATOM   6487  C  CA    . MET B 1 333 ? 137.348 144.652 82.741  1.00 155.84 ? 325 MET B CA    1 
ATOM   6488  C  C     . MET B 1 333 ? 136.475 145.852 83.089  1.00 157.32 ? 325 MET B C     1 
ATOM   6489  O  O     . MET B 1 333 ? 136.963 146.824 83.679  1.00 158.91 ? 325 MET B O     1 
ATOM   6490  C  CB    . MET B 1 333 ? 137.967 144.829 81.354  1.00 153.79 ? 325 MET B CB    1 
ATOM   6491  C  CG    . MET B 1 333 ? 139.201 143.976 81.111  1.00 153.20 ? 325 MET B CG    1 
ATOM   6492  S  SD    . MET B 1 333 ? 139.915 144.238 79.476  1.00 156.45 ? 325 MET B SD    1 
ATOM   6493  C  CE    . MET B 1 333 ? 141.329 143.141 79.544  1.00 150.56 ? 325 MET B CE    1 
ATOM   6494  N  N     . GLY B 1 334 ? 135.192 145.805 82.737  1.00 156.11 ? 326 GLY B N     1 
ATOM   6495  C  CA    . GLY B 1 334 ? 134.282 146.888 83.053  1.00 156.14 ? 326 GLY B CA    1 
ATOM   6496  C  C     . GLY B 1 334 ? 133.295 146.563 84.157  1.00 156.88 ? 326 GLY B C     1 
ATOM   6497  O  O     . GLY B 1 334 ? 132.985 147.419 84.991  1.00 157.28 ? 326 GLY B O     1 
ATOM   6498  N  N     . MET B 1 335 ? 132.792 145.326 84.173  1.00 156.85 ? 327 MET B N     1 
ATOM   6499  C  CA    . MET B 1 335 ? 131.800 144.946 85.174  1.00 156.50 ? 327 MET B CA    1 
ATOM   6500  C  C     . MET B 1 335 ? 132.434 144.758 86.547  1.00 155.96 ? 327 MET B C     1 
ATOM   6501  O  O     . MET B 1 335 ? 131.857 145.164 87.563  1.00 153.60 ? 327 MET B O     1 
ATOM   6502  C  CB    . MET B 1 335 ? 131.075 143.672 84.741  1.00 153.45 ? 327 MET B CB    1 
ATOM   6503  C  CG    . MET B 1 335 ? 130.258 143.822 83.469  1.00 150.96 ? 327 MET B CG    1 
ATOM   6504  S  SD    . MET B 1 335 ? 128.921 145.018 83.639  1.00 150.69 ? 327 MET B SD    1 
ATOM   6505  C  CE    . MET B 1 335 ? 127.969 144.276 84.962  1.00 142.67 ? 327 MET B CE    1 
ATOM   6506  N  N     . LEU B 1 336 ? 133.610 144.132 86.597  1.00 158.39 ? 328 LEU B N     1 
ATOM   6507  C  CA    . LEU B 1 336 ? 134.394 143.858 87.800  1.00 161.13 ? 328 LEU B CA    1 
ATOM   6508  C  C     . LEU B 1 336 ? 133.716 142.881 88.755  1.00 161.41 ? 328 LEU B C     1 
ATOM   6509  O  O     . LEU B 1 336 ? 134.282 142.588 89.816  1.00 159.03 ? 328 LEU B O     1 
ATOM   6510  C  CB    . LEU B 1 336 ? 134.742 145.137 88.578  1.00 161.85 ? 328 LEU B CB    1 
ATOM   6511  C  CG    . LEU B 1 336 ? 135.608 146.176 87.861  1.00 159.58 ? 328 LEU B CG    1 
ATOM   6512  C  CD1   . LEU B 1 336 ? 135.759 147.424 88.716  1.00 155.89 ? 328 LEU B CD1   1 
ATOM   6513  C  CD2   . LEU B 1 336 ? 136.969 145.595 87.515  1.00 157.65 ? 328 LEU B CD2   1 
ATOM   6514  N  N     . SER B 1 337 ? 132.535 142.362 88.423  1.00 161.26 ? 329 SER B N     1 
ATOM   6515  C  CA    . SER B 1 337 ? 131.844 141.430 89.303  1.00 155.53 ? 329 SER B CA    1 
ATOM   6516  C  C     . SER B 1 337 ? 130.823 140.644 88.494  1.00 151.77 ? 329 SER B C     1 
ATOM   6517  O  O     . SER B 1 337 ? 130.445 141.036 87.387  1.00 151.46 ? 329 SER B O     1 
ATOM   6518  C  CB    . SER B 1 337 ? 131.162 142.156 90.468  1.00 152.63 ? 329 SER B CB    1 
ATOM   6519  O  OG    . SER B 1 337 ? 130.187 143.070 89.999  1.00 152.85 ? 329 SER B OG    1 
ATOM   6520  N  N     . THR B 1 338 ? 130.382 139.526 89.066  1.00 148.34 ? 330 THR B N     1 
ATOM   6521  C  CA    . THR B 1 338 ? 129.379 138.663 88.458  1.00 143.90 ? 330 THR B CA    1 
ATOM   6522  C  C     . THR B 1 338 ? 128.145 138.630 89.347  1.00 141.10 ? 330 THR B C     1 
ATOM   6523  O  O     . THR B 1 338 ? 128.254 138.419 90.559  1.00 139.17 ? 330 THR B O     1 
ATOM   6524  C  CB    . THR B 1 338 ? 129.915 137.243 88.252  1.00 138.59 ? 330 THR B CB    1 
ATOM   6525  O  OG1   . THR B 1 338 ? 130.156 136.632 89.525  1.00 135.04 ? 330 THR B OG1   1 
ATOM   6526  C  CG2   . THR B 1 338 ? 131.211 137.272 87.458  1.00 138.51 ? 330 THR B CG2   1 
ATOM   6527  N  N     . SER B 1 339 ? 126.975 138.838 88.744  1.00 138.32 ? 331 SER B N     1 
ATOM   6528  C  CA    . SER B 1 339 ? 125.723 138.848 89.491  1.00 132.55 ? 331 SER B CA    1 
ATOM   6529  C  C     . SER B 1 339 ? 125.079 137.469 89.563  1.00 126.99 ? 331 SER B C     1 
ATOM   6530  O  O     . SER B 1 339 ? 124.603 137.064 90.629  1.00 122.74 ? 331 SER B O     1 
ATOM   6531  C  CB    . SER B 1 339 ? 124.746 139.847 88.867  1.00 130.10 ? 331 SER B CB    1 
ATOM   6532  O  OG    . SER B 1 339 ? 125.275 141.162 88.892  1.00 132.07 ? 331 SER B OG    1 
ATOM   6533  N  N     . LEU B 1 340 ? 125.053 136.738 88.448  1.00 126.91 ? 332 LEU B N     1 
ATOM   6534  C  CA    . LEU B 1 340 ? 124.486 135.396 88.402  1.00 122.39 ? 332 LEU B CA    1 
ATOM   6535  C  C     . LEU B 1 340 ? 125.545 134.338 88.114  1.00 122.72 ? 332 LEU B C     1 
ATOM   6536  O  O     . LEU B 1 340 ? 125.219 133.267 87.590  1.00 122.30 ? 332 LEU B O     1 
ATOM   6537  C  CB    . LEU B 1 340 ? 123.364 135.325 87.366  1.00 118.50 ? 332 LEU B CB    1 
ATOM   6538  C  CG    . LEU B 1 340 ? 122.177 136.257 87.613  1.00 117.78 ? 332 LEU B CG    1 
ATOM   6539  C  CD1   . LEU B 1 340 ? 121.084 136.023 86.583  1.00 114.96 ? 332 LEU B CD1   1 
ATOM   6540  C  CD2   . LEU B 1 340 ? 121.639 136.075 89.022  1.00 119.20 ? 332 LEU B CD2   1 
ATOM   6541  N  N     . ALA B 1 341 ? 126.801 134.626 88.435  1.00 122.61 ? 333 ALA B N     1 
ATOM   6542  C  CA    . ALA B 1 341 ? 127.931 133.689 88.303  1.00 118.77 ? 333 ALA B CA    1 
ATOM   6543  C  C     . ALA B 1 341 ? 128.082 133.326 86.821  1.00 117.88 ? 333 ALA B C     1 
ATOM   6544  O  O     . ALA B 1 341 ? 127.825 134.173 85.950  1.00 120.76 ? 333 ALA B O     1 
ATOM   6545  C  CB    . ALA B 1 341 ? 127.733 132.511 89.236  1.00 121.05 ? 333 ALA B CB    1 
ATOM   6546  N  N     . ASP B 1 342 ? 128.464 132.082 86.512  1.00 118.49 ? 334 ASP B N     1 
ATOM   6547  C  CA    . ASP B 1 342 ? 128.839 131.716 85.149  1.00 118.96 ? 334 ASP B CA    1 
ATOM   6548  C  C     . ASP B 1 342 ? 127.708 131.956 84.161  1.00 117.76 ? 334 ASP B C     1 
ATOM   6549  O  O     . ASP B 1 342 ? 127.966 132.176 82.971  1.00 120.41 ? 334 ASP B O     1 
ATOM   6550  C  CB    . ASP B 1 342 ? 129.272 130.251 85.099  1.00 118.83 ? 334 ASP B CB    1 
ATOM   6551  C  CG    . ASP B 1 342 ? 128.106 129.293 85.249  1.00 117.14 ? 334 ASP B CG    1 
ATOM   6552  O  OD1   . ASP B 1 342 ? 127.173 129.601 86.021  1.00 116.89 ? 334 ASP B OD1   1 
ATOM   6553  O  OD2   . ASP B 1 342 ? 128.120 128.233 84.591  1.00 114.01 ? 334 ASP B OD2   1 
ATOM   6554  N  N     . GLN B 1 343 ? 126.458 131.916 84.630  1.00 113.72 ? 335 GLN B N     1 
ATOM   6555  C  CA    . GLN B 1 343 ? 125.326 132.203 83.757  1.00 110.83 ? 335 GLN B CA    1 
ATOM   6556  C  C     . GLN B 1 343 ? 125.529 133.525 83.033  1.00 115.13 ? 335 GLN B C     1 
ATOM   6557  O  O     . GLN B 1 343 ? 125.420 133.596 81.802  1.00 117.47 ? 335 GLN B O     1 
ATOM   6558  C  CB    . GLN B 1 343 ? 124.030 132.225 84.569  1.00 105.06 ? 335 GLN B CB    1 
ATOM   6559  C  CG    . GLN B 1 343 ? 122.788 132.501 83.741  1.00 99.97  ? 335 GLN B CG    1 
ATOM   6560  C  CD    . GLN B 1 343 ? 121.545 132.651 84.591  1.00 95.70  ? 335 GLN B CD    1 
ATOM   6561  O  OE1   . GLN B 1 343 ? 121.629 132.865 85.799  1.00 98.55  ? 335 GLN B OE1   1 
ATOM   6562  N  NE2   . GLN B 1 343 ? 120.382 132.537 83.963  1.00 89.87  ? 335 GLN B NE2   1 
ATOM   6563  N  N     . ASP B 1 344 ? 125.875 134.576 83.782  1.00 115.35 ? 336 ASP B N     1 
ATOM   6564  C  CA    . ASP B 1 344 ? 126.165 135.864 83.162  1.00 118.38 ? 336 ASP B CA    1 
ATOM   6565  C  C     . ASP B 1 344 ? 127.226 135.714 82.082  1.00 121.30 ? 336 ASP B C     1 
ATOM   6566  O  O     . ASP B 1 344 ? 127.044 136.170 80.946  1.00 121.55 ? 336 ASP B O     1 
ATOM   6567  C  CB    . ASP B 1 344 ? 126.617 136.868 84.223  1.00 123.51 ? 336 ASP B CB    1 
ATOM   6568  C  CG    . ASP B 1 344 ? 125.510 137.235 85.186  1.00 128.53 ? 336 ASP B CG    1 
ATOM   6569  O  OD1   . ASP B 1 344 ? 124.328 137.154 84.790  1.00 129.28 ? 336 ASP B OD1   1 
ATOM   6570  O  OD2   . ASP B 1 344 ? 125.822 137.609 86.335  1.00 130.54 ? 336 ASP B OD2   1 
ATOM   6571  N  N     . ILE B 1 345 ? 128.323 135.027 82.411  1.00 121.68 ? 337 ILE B N     1 
ATOM   6572  C  CA    . ILE B 1 345 ? 129.382 134.798 81.434  1.00 118.26 ? 337 ILE B CA    1 
ATOM   6573  C  C     . ILE B 1 345 ? 128.817 134.122 80.195  1.00 115.94 ? 337 ILE B C     1 
ATOM   6574  O  O     . ILE B 1 345 ? 129.107 134.531 79.063  1.00 118.93 ? 337 ILE B O     1 
ATOM   6575  C  CB    . ILE B 1 345 ? 130.522 133.975 82.062  1.00 118.36 ? 337 ILE B CB    1 
ATOM   6576  C  CG1   . ILE B 1 345 ? 131.196 134.771 83.181  1.00 123.49 ? 337 ILE B CG1   1 
ATOM   6577  C  CG2   . ILE B 1 345 ? 131.535 133.571 81.005  1.00 118.48 ? 337 ILE B CG2   1 
ATOM   6578  C  CD1   . ILE B 1 345 ? 132.342 134.042 83.845  1.00 126.48 ? 337 ILE B CD1   1 
ATOM   6579  N  N     . PHE B 1 346 ? 127.974 133.102 80.388  1.00 113.07 ? 338 PHE B N     1 
ATOM   6580  C  CA    . PHE B 1 346 ? 127.337 132.447 79.251  1.00 109.75 ? 338 PHE B CA    1 
ATOM   6581  C  C     . PHE B 1 346 ? 126.665 133.473 78.352  1.00 113.25 ? 338 PHE B C     1 
ATOM   6582  O  O     . PHE B 1 346 ? 126.922 133.521 77.143  1.00 117.35 ? 338 PHE B O     1 
ATOM   6583  C  CB    . PHE B 1 346 ? 126.320 131.413 79.736  1.00 110.80 ? 338 PHE B CB    1 
ATOM   6584  C  CG    . PHE B 1 346 ? 126.875 130.025 79.863  1.00 111.09 ? 338 PHE B CG    1 
ATOM   6585  C  CD1   . PHE B 1 346 ? 126.970 129.202 78.755  1.00 106.18 ? 338 PHE B CD1   1 
ATOM   6586  C  CD2   . PHE B 1 346 ? 127.289 129.538 81.091  1.00 111.10 ? 338 PHE B CD2   1 
ATOM   6587  C  CE1   . PHE B 1 346 ? 127.476 127.921 78.867  1.00 107.33 ? 338 PHE B CE1   1 
ATOM   6588  C  CE2   . PHE B 1 346 ? 127.793 128.257 81.210  1.00 107.88 ? 338 PHE B CE2   1 
ATOM   6589  C  CZ    . PHE B 1 346 ? 127.889 127.449 80.096  1.00 107.04 ? 338 PHE B CZ    1 
ATOM   6590  N  N     . ASN B 1 347 ? 125.849 134.349 78.946  1.00 115.65 ? 339 ASN B N     1 
ATOM   6591  C  CA    . ASN B 1 347 ? 125.141 135.349 78.157  1.00 116.67 ? 339 ASN B CA    1 
ATOM   6592  C  C     . ASN B 1 347 ? 126.117 136.211 77.373  1.00 117.05 ? 339 ASN B C     1 
ATOM   6593  O  O     . ASN B 1 347 ? 125.873 136.533 76.204  1.00 115.25 ? 339 ASN B O     1 
ATOM   6594  C  CB    . ASN B 1 347 ? 124.265 136.211 79.065  1.00 118.42 ? 339 ASN B CB    1 
ATOM   6595  C  CG    . ASN B 1 347 ? 123.214 135.401 79.797  1.00 114.39 ? 339 ASN B CG    1 
ATOM   6596  O  OD1   . ASN B 1 347 ? 122.119 135.172 79.283  1.00 109.63 ? 339 ASN B OD1   1 
ATOM   6597  N  ND2   . ASN B 1 347 ? 123.543 134.961 81.005  1.00 114.03 ? 339 ASN B ND2   1 
ATOM   6598  N  N     . ALA B 1 348 ? 127.251 136.558 77.988  1.00 119.50 ? 340 ALA B N     1 
ATOM   6599  C  CA    . ALA B 1 348 ? 128.245 137.365 77.292  1.00 120.18 ? 340 ALA B CA    1 
ATOM   6600  C  C     . ALA B 1 348 ? 128.720 136.666 76.026  1.00 115.77 ? 340 ALA B C     1 
ATOM   6601  O  O     . ALA B 1 348 ? 128.807 137.288 74.960  1.00 117.74 ? 340 ALA B O     1 
ATOM   6602  C  CB    . ALA B 1 348 ? 129.418 137.668 78.221  1.00 123.03 ? 340 ALA B CB    1 
ATOM   6603  N  N     . VAL B 1 349 ? 128.994 135.362 76.115  1.00 113.82 ? 341 VAL B N     1 
ATOM   6604  C  CA    . VAL B 1 349 ? 129.366 134.611 74.920  1.00 110.28 ? 341 VAL B CA    1 
ATOM   6605  C  C     . VAL B 1 349 ? 128.237 134.659 73.904  1.00 111.29 ? 341 VAL B C     1 
ATOM   6606  O  O     . VAL B 1 349 ? 128.467 134.853 72.703  1.00 117.50 ? 341 VAL B O     1 
ATOM   6607  C  CB    . VAL B 1 349 ? 129.740 133.164 75.289  1.00 112.76 ? 341 VAL B CB    1 
ATOM   6608  C  CG1   . VAL B 1 349 ? 130.079 132.371 74.038  1.00 112.90 ? 341 VAL B CG1   1 
ATOM   6609  C  CG2   . VAL B 1 349 ? 130.905 133.152 76.265  1.00 116.78 ? 341 VAL B CG2   1 
ATOM   6610  N  N     . ILE B 1 350 ? 126.995 134.523 74.376  1.00 108.23 ? 342 ILE B N     1 
ATOM   6611  C  CA    . ILE B 1 350 ? 125.842 134.594 73.486  1.00 110.78 ? 342 ILE B CA    1 
ATOM   6612  C  C     . ILE B 1 350 ? 125.799 135.939 72.776  1.00 118.13 ? 342 ILE B C     1 
ATOM   6613  O  O     . ILE B 1 350 ? 125.298 136.041 71.649  1.00 119.03 ? 342 ILE B O     1 
ATOM   6614  C  CB    . ILE B 1 350 ? 124.549 134.324 74.280  1.00 111.96 ? 342 ILE B CB    1 
ATOM   6615  C  CG1   . ILE B 1 350 ? 124.670 133.008 75.048  1.00 107.40 ? 342 ILE B CG1   1 
ATOM   6616  C  CG2   . ILE B 1 350 ? 123.344 134.280 73.354  1.00 112.32 ? 342 ILE B CG2   1 
ATOM   6617  C  CD1   . ILE B 1 350 ? 123.539 132.757 76.013  1.00 106.26 ? 342 ILE B CD1   1 
ATOM   6618  N  N     . LYS B 1 351 ? 126.331 136.988 73.408  1.00 120.09 ? 343 LYS B N     1 
ATOM   6619  C  CA    . LYS B 1 351 ? 126.390 138.282 72.740  1.00 119.90 ? 343 LYS B CA    1 
ATOM   6620  C  C     . LYS B 1 351 ? 127.404 138.272 71.603  1.00 116.63 ? 343 LYS B C     1 
ATOM   6621  O  O     . LYS B 1 351 ? 127.141 138.820 70.526  1.00 114.51 ? 343 LYS B O     1 
ATOM   6622  C  CB    . LYS B 1 351 ? 126.725 139.381 73.747  1.00 119.23 ? 343 LYS B CB    1 
ATOM   6623  C  CG    . LYS B 1 351 ? 126.730 140.778 73.148  1.00 121.59 ? 343 LYS B CG    1 
ATOM   6624  C  CD    . LYS B 1 351 ? 127.059 141.828 74.193  1.00 125.37 ? 343 LYS B CD    1 
ATOM   6625  C  CE    . LYS B 1 351 ? 126.967 143.230 73.615  1.00 127.68 ? 343 LYS B CE    1 
ATOM   6626  N  NZ    . LYS B 1 351 ? 127.251 144.272 74.640  1.00 128.63 ? 343 LYS B NZ    1 
ATOM   6627  N  N     . GLN B 1 352 ? 128.567 137.652 71.819  1.00 114.81 ? 344 GLN B N     1 
ATOM   6628  C  CA    . GLN B 1 352 ? 129.610 137.691 70.799  1.00 111.82 ? 344 GLN B CA    1 
ATOM   6629  C  C     . GLN B 1 352 ? 129.287 136.771 69.630  1.00 110.47 ? 344 GLN B C     1 
ATOM   6630  O  O     . GLN B 1 352 ? 129.465 137.151 68.467  1.00 115.38 ? 344 GLN B O     1 
ATOM   6631  C  CB    . GLN B 1 352 ? 130.961 137.323 71.410  1.00 114.54 ? 344 GLN B CB    1 
ATOM   6632  C  CG    . GLN B 1 352 ? 131.507 138.354 72.380  1.00 121.91 ? 344 GLN B CG    1 
ATOM   6633  C  CD    . GLN B 1 352 ? 132.914 138.026 72.835  1.00 129.34 ? 344 GLN B CD    1 
ATOM   6634  O  OE1   . GLN B 1 352 ? 133.445 138.653 73.750  1.00 132.74 ? 344 GLN B OE1   1 
ATOM   6635  N  NE2   . GLN B 1 352 ? 133.527 137.037 72.195  1.00 127.19 ? 344 GLN B NE2   1 
ATOM   6636  N  N     . ASN B 1 353 ? 128.812 135.560 69.914  1.00 108.27 ? 345 ASN B N     1 
ATOM   6637  C  CA    . ASN B 1 353 ? 128.550 134.550 68.890  1.00 107.84 ? 345 ASN B CA    1 
ATOM   6638  C  C     . ASN B 1 353 ? 127.146 133.996 69.087  1.00 106.48 ? 345 ASN B C     1 
ATOM   6639  O  O     . ASN B 1 353 ? 126.968 132.893 69.621  1.00 107.13 ? 345 ASN B O     1 
ATOM   6640  C  CB    . ASN B 1 353 ? 129.597 133.437 68.936  1.00 108.69 ? 345 ASN B CB    1 
ATOM   6641  C  CG    . ASN B 1 353 ? 131.011 133.961 68.772  1.00 109.96 ? 345 ASN B CG    1 
ATOM   6642  O  OD1   . ASN B 1 353 ? 131.550 133.992 67.666  1.00 101.97 ? 345 ASN B OD1   1 
ATOM   6643  N  ND2   . ASN B 1 353 ? 131.618 134.381 69.876  1.00 112.50 ? 345 ASN B ND2   1 
ATOM   6644  N  N     . PRO B 1 354 ? 126.119 134.741 68.671  1.00 104.00 ? 346 PRO B N     1 
ATOM   6645  C  CA    . PRO B 1 354 ? 124.742 134.242 68.822  1.00 102.20 ? 346 PRO B CA    1 
ATOM   6646  C  C     . PRO B 1 354 ? 124.458 132.978 68.032  1.00 97.58  ? 346 PRO B C     1 
ATOM   6647  O  O     . PRO B 1 354 ? 123.500 132.266 68.358  1.00 95.37  ? 346 PRO B O     1 
ATOM   6648  C  CB    . PRO B 1 354 ? 123.887 135.415 68.321  1.00 103.66 ? 346 PRO B CB    1 
ATOM   6649  C  CG    . PRO B 1 354 ? 124.780 136.612 68.412  1.00 105.00 ? 346 PRO B CG    1 
ATOM   6650  C  CD    . PRO B 1 354 ? 126.154 136.104 68.118  1.00 103.44 ? 346 PRO B CD    1 
ATOM   6651  N  N     . PHE B 1 355 ? 125.250 132.676 67.003  1.00 96.01  ? 347 PHE B N     1 
ATOM   6652  C  CA    . PHE B 1 355 ? 125.012 131.495 66.181  1.00 96.72  ? 347 PHE B CA    1 
ATOM   6653  C  C     . PHE B 1 355 ? 125.338 130.192 66.899  1.00 95.52  ? 347 PHE B C     1 
ATOM   6654  O  O     . PHE B 1 355 ? 124.993 129.124 66.384  1.00 94.15  ? 347 PHE B O     1 
ATOM   6655  C  CB    . PHE B 1 355 ? 125.819 131.587 64.884  1.00 98.16  ? 347 PHE B CB    1 
ATOM   6656  C  CG    . PHE B 1 355 ? 127.292 131.799 65.098  1.00 104.33 ? 347 PHE B CG    1 
ATOM   6657  C  CD1   . PHE B 1 355 ? 127.813 133.078 65.200  1.00 107.95 ? 347 PHE B CD1   1 
ATOM   6658  C  CD2   . PHE B 1 355 ? 128.156 130.721 65.189  1.00 102.82 ? 347 PHE B CD2   1 
ATOM   6659  C  CE1   . PHE B 1 355 ? 129.166 133.278 65.395  1.00 110.68 ? 347 PHE B CE1   1 
ATOM   6660  C  CE2   . PHE B 1 355 ? 129.511 130.915 65.384  1.00 103.37 ? 347 PHE B CE2   1 
ATOM   6661  C  CZ    . PHE B 1 355 ? 130.016 132.195 65.486  1.00 107.25 ? 347 PHE B CZ    1 
ATOM   6662  N  N     . LEU B 1 356 ? 125.996 130.247 68.056  1.00 94.30  ? 348 LEU B N     1 
ATOM   6663  C  CA    . LEU B 1 356 ? 126.333 129.041 68.801  1.00 89.66  ? 348 LEU B CA    1 
ATOM   6664  C  C     . LEU B 1 356 ? 125.184 128.519 69.651  1.00 83.20  ? 348 LEU B C     1 
ATOM   6665  O  O     . LEU B 1 356 ? 125.260 127.384 70.131  1.00 81.90  ? 348 LEU B O     1 
ATOM   6666  C  CB    . LEU B 1 356 ? 127.540 129.298 69.707  1.00 90.23  ? 348 LEU B CB    1 
ATOM   6667  C  CG    . LEU B 1 356 ? 128.863 129.680 69.044  1.00 98.68  ? 348 LEU B CG    1 
ATOM   6668  C  CD1   . LEU B 1 356 ? 129.922 129.952 70.101  1.00 97.54  ? 348 LEU B CD1   1 
ATOM   6669  C  CD2   . LEU B 1 356 ? 129.317 128.585 68.096  1.00 98.30  ? 348 LEU B CD2   1 
ATOM   6670  N  N     . VAL B 1 357 ? 124.129 129.305 69.843  1.00 82.10  ? 349 VAL B N     1 
ATOM   6671  C  CA    . VAL B 1 357 ? 123.077 128.999 70.805  1.00 72.01  ? 349 VAL B CA    1 
ATOM   6672  C  C     . VAL B 1 357 ? 121.848 128.503 70.059  1.00 73.29  ? 349 VAL B C     1 
ATOM   6673  O  O     . VAL B 1 357 ? 121.408 129.126 69.086  1.00 82.49  ? 349 VAL B O     1 
ATOM   6674  C  CB    . VAL B 1 357 ? 122.736 130.228 71.664  1.00 71.14  ? 349 VAL B CB    1 
ATOM   6675  C  CG1   . VAL B 1 357 ? 121.748 129.856 72.754  1.00 70.74  ? 349 VAL B CG1   1 
ATOM   6676  C  CG2   . VAL B 1 357 ? 124.000 130.822 72.259  1.00 72.66  ? 349 VAL B CG2   1 
ATOM   6677  N  N     . TYR B 1 358 ? 121.299 127.382 70.514  1.00 65.23  ? 350 TYR B N     1 
ATOM   6678  C  CA    . TYR B 1 358 ? 120.049 126.838 70.005  1.00 66.41  ? 350 TYR B CA    1 
ATOM   6679  C  C     . TYR B 1 358 ? 118.962 127.124 71.031  1.00 68.46  ? 350 TYR B C     1 
ATOM   6680  O  O     . TYR B 1 358 ? 119.060 126.685 72.183  1.00 70.34  ? 350 TYR B O     1 
ATOM   6681  C  CB    . TYR B 1 358 ? 120.173 125.337 69.745  1.00 65.81  ? 350 TYR B CB    1 
ATOM   6682  C  CG    . TYR B 1 358 ? 118.909 124.679 69.241  1.00 65.10  ? 350 TYR B CG    1 
ATOM   6683  C  CD1   . TYR B 1 358 ? 117.973 124.162 70.123  1.00 65.74  ? 350 TYR B CD1   1 
ATOM   6684  C  CD2   . TYR B 1 358 ? 118.660 124.563 67.882  1.00 66.99  ? 350 TYR B CD2   1 
ATOM   6685  C  CE1   . TYR B 1 358 ? 116.821 123.556 69.667  1.00 65.98  ? 350 TYR B CE1   1 
ATOM   6686  C  CE2   . TYR B 1 358 ? 117.512 123.958 67.417  1.00 67.80  ? 350 TYR B CE2   1 
ATOM   6687  C  CZ    . TYR B 1 358 ? 116.596 123.456 68.313  1.00 67.59  ? 350 TYR B CZ    1 
ATOM   6688  O  OH    . TYR B 1 358 ? 115.449 122.852 67.854  1.00 69.77  ? 350 TYR B OH    1 
ATOM   6689  N  N     . GLN B 1 359 ? 117.928 127.847 70.611  1.00 73.56  ? 351 GLN B N     1 
ATOM   6690  C  CA    . GLN B 1 359 ? 116.869 128.281 71.518  1.00 73.79  ? 351 GLN B CA    1 
ATOM   6691  C  C     . GLN B 1 359 ? 115.855 127.153 71.663  1.00 71.97  ? 351 GLN B C     1 
ATOM   6692  O  O     . GLN B 1 359 ? 115.033 126.917 70.775  1.00 71.42  ? 351 GLN B O     1 
ATOM   6693  C  CB    . GLN B 1 359 ? 116.218 129.560 71.006  1.00 76.86  ? 351 GLN B CB    1 
ATOM   6694  C  CG    . GLN B 1 359 ? 115.348 130.266 72.030  1.00 82.16  ? 351 GLN B CG    1 
ATOM   6695  C  CD    . GLN B 1 359 ? 114.982 131.675 71.609  1.00 92.96  ? 351 GLN B CD    1 
ATOM   6696  O  OE1   . GLN B 1 359 ? 115.319 132.115 70.510  1.00 96.38  ? 351 GLN B OE1   1 
ATOM   6697  N  NE2   . GLN B 1 359 ? 114.293 132.395 72.487  1.00 97.44  ? 351 GLN B NE2   1 
ATOM   6698  N  N     . LEU B 1 360 ? 115.919 126.452 72.791  1.00 71.32  ? 352 LEU B N     1 
ATOM   6699  C  CA    . LEU B 1 360 ? 114.987 125.383 73.086  1.00 70.84  ? 352 LEU B CA    1 
ATOM   6700  C  C     . LEU B 1 360 ? 113.606 125.952 73.397  1.00 74.72  ? 352 LEU B C     1 
ATOM   6701  O  O     . LEU B 1 360 ? 113.468 127.131 73.728  1.00 76.10  ? 352 LEU B O     1 
ATOM   6702  C  CB    . LEU B 1 360 ? 115.486 124.561 74.272  1.00 67.48  ? 352 LEU B CB    1 
ATOM   6703  C  CG    . LEU B 1 360 ? 116.826 123.839 74.134  1.00 64.38  ? 352 LEU B CG    1 
ATOM   6704  C  CD1   . LEU B 1 360 ? 117.287 123.320 75.484  1.00 63.43  ? 352 LEU B CD1   1 
ATOM   6705  C  CD2   . LEU B 1 360 ? 116.710 122.699 73.143  1.00 65.28  ? 352 LEU B CD2   1 
ATOM   6706  N  N     . PRO B 1 361 ? 112.562 125.131 73.285  1.00 75.32  ? 353 PRO B N     1 
ATOM   6707  C  CA    . PRO B 1 361 ? 111.235 125.569 73.726  1.00 75.80  ? 353 PRO B CA    1 
ATOM   6708  C  C     . PRO B 1 361 ? 111.236 125.932 75.203  1.00 74.55  ? 353 PRO B C     1 
ATOM   6709  O  O     . PRO B 1 361 ? 112.001 125.385 76.000  1.00 76.04  ? 353 PRO B O     1 
ATOM   6710  C  CB    . PRO B 1 361 ? 110.351 124.349 73.449  1.00 74.87  ? 353 PRO B CB    1 
ATOM   6711  C  CG    . PRO B 1 361 ? 111.041 123.638 72.341  1.00 75.40  ? 353 PRO B CG    1 
ATOM   6712  C  CD    . PRO B 1 361 ? 112.510 123.842 72.573  1.00 73.45  ? 353 PRO B CD    1 
ATOM   6713  N  N     . CYS B 1 362 ? 110.365 126.878 75.560  1.00 76.10  ? 354 CYS B N     1 
ATOM   6714  C  CA    . CYS B 1 362 ? 110.370 127.427 76.913  1.00 74.51  ? 354 CYS B CA    1 
ATOM   6715  C  C     . CYS B 1 362 ? 110.056 126.361 77.957  1.00 71.59  ? 354 CYS B C     1 
ATOM   6716  O  O     . CYS B 1 362 ? 110.655 126.351 79.040  1.00 68.77  ? 354 CYS B O     1 
ATOM   6717  C  CB    . CYS B 1 362 ? 109.375 128.582 77.012  1.00 79.38  ? 354 CYS B CB    1 
ATOM   6718  S  SG    . CYS B 1 362 ? 107.668 128.130 76.631  1.00 98.58  ? 354 CYS B SG    1 
ATOM   6719  N  N     . PHE B 1 363 ? 109.131 125.449 77.652  1.00 72.15  ? 355 PHE B N     1 
ATOM   6720  C  CA    . PHE B 1 363 ? 108.716 124.455 78.637  1.00 75.30  ? 355 PHE B CA    1 
ATOM   6721  C  C     . PHE B 1 363 ? 109.810 123.450 78.978  1.00 74.73  ? 355 PHE B C     1 
ATOM   6722  O  O     . PHE B 1 363 ? 109.554 122.534 79.769  1.00 71.32  ? 355 PHE B O     1 
ATOM   6723  C  CB    . PHE B 1 363 ? 107.462 123.720 78.156  1.00 77.84  ? 355 PHE B CB    1 
ATOM   6724  C  CG    . PHE B 1 363 ? 107.559 123.196 76.753  1.00 76.29  ? 355 PHE B CG    1 
ATOM   6725  C  CD1   . PHE B 1 363 ? 108.134 121.964 76.498  1.00 74.40  ? 355 PHE B CD1   1 
ATOM   6726  C  CD2   . PHE B 1 363 ? 107.054 123.925 75.690  1.00 78.57  ? 355 PHE B CD2   1 
ATOM   6727  C  CE1   . PHE B 1 363 ? 108.218 121.476 75.210  1.00 77.10  ? 355 PHE B CE1   1 
ATOM   6728  C  CE2   . PHE B 1 363 ? 107.133 123.441 74.401  1.00 79.98  ? 355 PHE B CE2   1 
ATOM   6729  C  CZ    . PHE B 1 363 ? 107.715 122.213 74.161  1.00 78.99  ? 355 PHE B CZ    1 
ATOM   6730  N  N     . TRP B 1 364 ? 111.008 123.586 78.407  1.00 76.38  ? 356 TRP B N     1 
ATOM   6731  C  CA    . TRP B 1 364 ? 112.150 122.790 78.834  1.00 69.54  ? 356 TRP B CA    1 
ATOM   6732  C  C     . TRP B 1 364 ? 112.863 123.381 80.040  1.00 65.69  ? 356 TRP B C     1 
ATOM   6733  O  O     . TRP B 1 364 ? 113.761 122.732 80.584  1.00 67.98  ? 356 TRP B O     1 
ATOM   6734  C  CB    . TRP B 1 364 ? 113.154 122.627 77.692  1.00 67.30  ? 356 TRP B CB    1 
ATOM   6735  C  CG    . TRP B 1 364 ? 112.743 121.622 76.672  1.00 67.41  ? 356 TRP B CG    1 
ATOM   6736  C  CD1   . TRP B 1 364 ? 112.486 121.852 75.356  1.00 67.45  ? 356 TRP B CD1   1 
ATOM   6737  C  CD2   . TRP B 1 364 ? 112.530 120.223 76.885  1.00 65.46  ? 356 TRP B CD2   1 
ATOM   6738  N  NE1   . TRP B 1 364 ? 112.131 120.684 74.732  1.00 69.39  ? 356 TRP B NE1   1 
ATOM   6739  C  CE2   . TRP B 1 364 ? 112.149 119.668 75.651  1.00 68.53  ? 356 TRP B CE2   1 
ATOM   6740  C  CE3   . TRP B 1 364 ? 112.626 119.385 78.000  1.00 66.51  ? 356 TRP B CE3   1 
ATOM   6741  C  CZ2   . TRP B 1 364 ? 111.864 118.315 75.498  1.00 69.63  ? 356 TRP B CZ2   1 
ATOM   6742  C  CZ3   . TRP B 1 364 ? 112.342 118.044 77.846  1.00 66.40  ? 356 TRP B CZ3   1 
ATOM   6743  C  CH2   . TRP B 1 364 ? 111.967 117.521 76.605  1.00 67.57  ? 356 TRP B CH2   1 
ATOM   6744  N  N     . ASN B 1 365 ? 112.514 124.600 80.450  1.00 66.39  ? 357 ASN B N     1 
ATOM   6745  C  CA    . ASN B 1 365 ? 113.111 125.200 81.641  1.00 63.48  ? 357 ASN B CA    1 
ATOM   6746  C  C     . ASN B 1 365 ? 112.119 126.227 82.179  1.00 69.75  ? 357 ASN B C     1 
ATOM   6747  O  O     . ASN B 1 365 ? 112.127 127.383 81.748  1.00 75.39  ? 357 ASN B O     1 
ATOM   6748  C  CB    . ASN B 1 365 ? 114.458 125.828 81.313  1.00 61.64  ? 357 ASN B CB    1 
ATOM   6749  C  CG    . ASN B 1 365 ? 115.162 126.363 82.533  1.00 59.31  ? 357 ASN B CG    1 
ATOM   6750  O  OD1   . ASN B 1 365 ? 114.819 126.019 83.661  1.00 65.81  ? 357 ASN B OD1   1 
ATOM   6751  N  ND2   . ASN B 1 365 ? 116.158 127.210 82.317  1.00 57.63  ? 357 ASN B ND2   1 
ATOM   6752  N  N     . VAL B 1 366 ? 111.281 125.803 83.119  1.00 64.42  ? 358 VAL B N     1 
ATOM   6753  C  CA    . VAL B 1 366 ? 110.230 126.643 83.682  1.00 64.04  ? 358 VAL B CA    1 
ATOM   6754  C  C     . VAL B 1 366 ? 110.782 127.244 84.969  1.00 66.46  ? 358 VAL B C     1 
ATOM   6755  O  O     . VAL B 1 366 ? 110.814 126.588 86.012  1.00 69.67  ? 358 VAL B O     1 
ATOM   6756  C  CB    . VAL B 1 366 ? 108.944 125.852 83.933  1.00 59.72  ? 358 VAL B CB    1 
ATOM   6757  C  CG1   . VAL B 1 366 ? 107.877 126.748 84.535  1.00 68.65  ? 358 VAL B CG1   1 
ATOM   6758  C  CG2   . VAL B 1 366 ? 108.450 125.230 82.643  1.00 63.14  ? 358 VAL B CG2   1 
ATOM   6759  N  N     . GLN B 1 367 ? 111.210 128.500 84.901  1.00 65.59  ? 359 GLN B N     1 
ATOM   6760  C  CA    . GLN B 1 367 ? 111.829 129.172 86.038  1.00 65.70  ? 359 GLN B CA    1 
ATOM   6761  C  C     . GLN B 1 367 ? 110.734 129.785 86.903  1.00 78.18  ? 359 GLN B C     1 
ATOM   6762  O  O     . GLN B 1 367 ? 110.078 130.749 86.497  1.00 86.33  ? 359 GLN B O     1 
ATOM   6763  C  CB    . GLN B 1 367 ? 112.808 130.239 85.560  1.00 69.85  ? 359 GLN B CB    1 
ATOM   6764  C  CG    . GLN B 1 367 ? 113.682 129.798 84.405  1.00 75.66  ? 359 GLN B CG    1 
ATOM   6765  C  CD    . GLN B 1 367 ? 114.550 130.919 83.878  1.00 86.10  ? 359 GLN B CD    1 
ATOM   6766  O  OE1   . GLN B 1 367 ? 115.152 131.668 84.647  1.00 90.14  ? 359 GLN B OE1   1 
ATOM   6767  N  NE2   . GLN B 1 367 ? 114.610 131.049 82.558  1.00 86.60  ? 359 GLN B NE2   1 
ATOM   6768  N  N     . LEU B 1 368 ? 110.539 129.228 88.094  1.00 80.45  ? 360 LEU B N     1 
ATOM   6769  C  CA    . LEU B 1 368 ? 109.568 129.758 89.050  1.00 80.85  ? 360 LEU B CA    1 
ATOM   6770  C  C     . LEU B 1 368 ? 110.218 130.756 90.002  1.00 90.06  ? 360 LEU B C     1 
ATOM   6771  O  O     . LEU B 1 368 ? 110.113 130.637 91.220  1.00 94.10  ? 360 LEU B O     1 
ATOM   6772  C  CB    . LEU B 1 368 ? 108.920 128.615 89.820  1.00 74.06  ? 360 LEU B CB    1 
ATOM   6773  C  CG    . LEU B 1 368 ? 108.262 127.511 88.996  1.00 71.39  ? 360 LEU B CG    1 
ATOM   6774  C  CD1   . LEU B 1 368 ? 107.649 126.466 89.912  1.00 69.72  ? 360 LEU B CD1   1 
ATOM   6775  C  CD2   . LEU B 1 368 ? 107.216 128.092 88.064  1.00 75.49  ? 360 LEU B CD2   1 
ATOM   6776  N  N     . SER B 1 369 ? 110.899 131.755 89.448  1.00 94.14  ? 361 SER B N     1 
ATOM   6777  C  CA    . SER B 1 369 ? 111.593 132.738 90.263  1.00 100.73 ? 361 SER B CA    1 
ATOM   6778  C  C     . SER B 1 369 ? 110.633 133.849 90.684  1.00 115.60 ? 361 SER B C     1 
ATOM   6779  O  O     . SER B 1 369 ? 109.453 133.860 90.325  1.00 116.18 ? 361 SER B O     1 
ATOM   6780  C  CB    . SER B 1 369 ? 112.791 133.306 89.508  1.00 97.05  ? 361 SER B CB    1 
ATOM   6781  O  OG    . SER B 1 369 ? 112.376 134.010 88.350  1.00 104.62 ? 361 SER B OG    1 
ATOM   6782  N  N     . ASP B 1 370 ? 111.149 134.796 91.461  1.00 122.00 ? 362 ASP B N     1 
ATOM   6783  C  CA    . ASP B 1 370 ? 110.340 135.921 91.908  1.00 124.52 ? 362 ASP B CA    1 
ATOM   6784  C  C     . ASP B 1 370 ? 110.004 136.833 90.735  1.00 125.97 ? 362 ASP B C     1 
ATOM   6785  O  O     . ASP B 1 370 ? 110.849 137.101 89.875  1.00 123.30 ? 362 ASP B O     1 
ATOM   6786  C  CB    . ASP B 1 370 ? 111.075 136.706 92.993  1.00 123.86 ? 362 ASP B CB    1 
ATOM   6787  C  CG    . ASP B 1 370 ? 111.477 135.838 94.170  1.00 121.97 ? 362 ASP B CG    1 
ATOM   6788  O  OD1   . ASP B 1 370 ? 110.761 134.855 94.456  1.00 120.98 ? 362 ASP B OD1   1 
ATOM   6789  O  OD2   . ASP B 1 370 ? 112.508 136.136 94.807  1.00 119.93 ? 362 ASP B OD2   1 
ATOM   6790  N  N     . HIS B 1 371 ? 108.758 137.309 90.707  1.00 129.11 ? 363 HIS B N     1 
ATOM   6791  C  CA    . HIS B 1 371 ? 108.267 138.181 89.638  1.00 129.68 ? 363 HIS B CA    1 
ATOM   6792  C  C     . HIS B 1 371 ? 108.474 137.542 88.268  1.00 128.92 ? 363 HIS B C     1 
ATOM   6793  O  O     . HIS B 1 371 ? 108.885 138.197 87.307  1.00 131.82 ? 363 HIS B O     1 
ATOM   6794  C  CB    . HIS B 1 371 ? 108.931 139.558 89.701  1.00 130.46 ? 363 HIS B CB    1 
ATOM   6795  C  CG    . HIS B 1 371 ? 108.840 140.214 91.044  1.00 133.38 ? 363 HIS B CG    1 
ATOM   6796  N  ND1   . HIS B 1 371 ? 107.773 141.003 91.416  1.00 134.21 ? 363 HIS B ND1   1 
ATOM   6797  C  CD2   . HIS B 1 371 ? 109.687 140.204 92.100  1.00 135.14 ? 363 HIS B CD2   1 
ATOM   6798  C  CE1   . HIS B 1 371 ? 107.964 141.448 92.645  1.00 134.91 ? 363 HIS B CE1   1 
ATOM   6799  N  NE2   . HIS B 1 371 ? 109.118 140.978 93.083  1.00 135.28 ? 363 HIS B NE2   1 
ATOM   6800  N  N     . THR B 1 372 ? 108.195 136.239 88.180  1.00 123.95 ? 364 THR B N     1 
ATOM   6801  C  CA    . THR B 1 372 ? 108.415 135.522 86.928  1.00 123.06 ? 364 THR B CA    1 
ATOM   6802  C  C     . THR B 1 372 ? 107.472 136.008 85.832  1.00 130.36 ? 364 THR B C     1 
ATOM   6803  O  O     . THR B 1 372 ? 107.912 136.290 84.711  1.00 130.21 ? 364 THR B O     1 
ATOM   6804  C  CB    . THR B 1 372 ? 108.260 134.017 87.152  1.00 114.36 ? 364 THR B CB    1 
ATOM   6805  O  OG1   . THR B 1 372 ? 108.185 133.344 85.890  1.00 115.08 ? 364 THR B OG1   1 
ATOM   6806  C  CG2   . THR B 1 372 ? 107.011 133.714 87.971  1.00 112.23 ? 364 THR B CG2   1 
ATOM   6807  N  N     . ARG B 1 373 ? 106.176 136.118 86.140  1.00 131.12 ? 365 ARG B N     1 
ATOM   6808  C  CA    . ARG B 1 373 ? 105.168 136.610 85.204  1.00 129.40 ? 365 ARG B CA    1 
ATOM   6809  C  C     . ARG B 1 373 ? 105.200 135.855 83.881  1.00 129.68 ? 365 ARG B C     1 
ATOM   6810  O  O     . ARG B 1 373 ? 105.013 136.452 82.817  1.00 130.07 ? 365 ARG B O     1 
ATOM   6811  C  CB    . ARG B 1 373 ? 105.353 138.108 84.958  1.00 131.28 ? 365 ARG B CB    1 
ATOM   6812  C  CG    . ARG B 1 373 ? 105.205 138.966 86.202  1.00 137.00 ? 365 ARG B CG    1 
ATOM   6813  C  CD    . ARG B 1 373 ? 105.350 140.443 85.870  1.00 145.58 ? 365 ARG B CD    1 
ATOM   6814  N  NE    . ARG B 1 373 ? 105.104 141.293 87.030  1.00 152.19 ? 365 ARG B NE    1 
ATOM   6815  C  CZ    . ARG B 1 373 ? 105.079 142.618 86.995  1.00 152.81 ? 365 ARG B CZ    1 
ATOM   6816  N  NH1   . ARG B 1 373 ? 105.282 143.285 85.871  1.00 152.20 ? 365 ARG B NH1   1 
ATOM   6817  N  NH2   . ARG B 1 373 ? 104.841 143.292 88.117  1.00 152.40 ? 365 ARG B NH2   1 
ATOM   6818  N  N     . SER B 1 374 ? 105.438 134.543 83.936  1.00 129.30 ? 366 SER B N     1 
ATOM   6819  C  CA    . SER B 1 374 ? 105.526 133.709 82.744  1.00 124.97 ? 366 SER B CA    1 
ATOM   6820  C  C     . SER B 1 374 ? 104.325 132.788 82.578  1.00 123.66 ? 366 SER B C     1 
ATOM   6821  O  O     . SER B 1 374 ? 104.489 131.636 82.157  1.00 121.88 ? 366 SER B O     1 
ATOM   6822  C  CB    . SER B 1 374 ? 106.820 132.894 82.770  1.00 119.40 ? 366 SER B CB    1 
ATOM   6823  O  OG    . SER B 1 374 ? 106.864 132.047 83.905  1.00 115.25 ? 366 SER B OG    1 
ATOM   6824  N  N     . GLU B 1 375 ? 103.120 133.268 82.899  1.00 124.63 ? 367 GLU B N     1 
ATOM   6825  C  CA    . GLU B 1 375 ? 101.938 132.414 82.847  1.00 124.62 ? 367 GLU B CA    1 
ATOM   6826  C  C     . GLU B 1 375 ? 101.706 131.848 81.452  1.00 123.38 ? 367 GLU B C     1 
ATOM   6827  O  O     . GLU B 1 375 ? 101.218 130.721 81.314  1.00 122.34 ? 367 GLU B O     1 
ATOM   6828  C  CB    . GLU B 1 375 ? 100.708 133.196 83.312  1.00 127.40 ? 367 GLU B CB    1 
ATOM   6829  C  CG    . GLU B 1 375 ? 100.949 134.069 84.535  1.00 128.71 ? 367 GLU B CG    1 
ATOM   6830  C  CD    . GLU B 1 375 ? 101.321 133.270 85.769  1.00 131.61 ? 367 GLU B CD    1 
ATOM   6831  O  OE1   . GLU B 1 375 ? 100.915 132.092 85.866  1.00 130.64 ? 367 GLU B OE1   1 
ATOM   6832  O  OE2   . GLU B 1 375 ? 102.024 133.820 86.643  1.00 131.84 ? 367 GLU B OE2   1 
ATOM   6833  N  N     . GLN B 1 376 ? 102.043 132.612 80.412  1.00 125.99 ? 368 GLN B N     1 
ATOM   6834  C  CA    . GLN B 1 376 ? 101.867 132.123 79.048  1.00 126.36 ? 368 GLN B CA    1 
ATOM   6835  C  C     . GLN B 1 376 ? 102.775 130.933 78.765  1.00 121.09 ? 368 GLN B C     1 
ATOM   6836  O  O     . GLN B 1 376 ? 102.405 130.025 78.011  1.00 117.91 ? 368 GLN B O     1 
ATOM   6837  C  CB    . GLN B 1 376 ? 102.131 133.251 78.051  1.00 129.84 ? 368 GLN B CB    1 
ATOM   6838  C  CG    . GLN B 1 376 ? 101.208 134.447 78.214  1.00 135.45 ? 368 GLN B CG    1 
ATOM   6839  C  CD    . GLN B 1 376 ? 101.541 135.575 77.257  1.00 144.04 ? 368 GLN B CD    1 
ATOM   6840  O  OE1   . GLN B 1 376 ? 102.565 135.545 76.575  1.00 148.57 ? 368 GLN B OE1   1 
ATOM   6841  N  NE2   . GLN B 1 376 ? 100.673 136.578 77.202  1.00 141.45 ? 368 GLN B NE2   1 
ATOM   6842  N  N     . CYS B 1 377 ? 103.971 130.923 79.359  1.00 120.56 ? 369 CYS B N     1 
ATOM   6843  C  CA    . CYS B 1 377 ? 104.919 129.844 79.101  1.00 118.00 ? 369 CYS B CA    1 
ATOM   6844  C  C     . CYS B 1 377 ? 104.378 128.500 79.574  1.00 115.51 ? 369 CYS B C     1 
ATOM   6845  O  O     . CYS B 1 377 ? 104.500 127.492 78.869  1.00 111.34 ? 369 CYS B O     1 
ATOM   6846  C  CB    . CYS B 1 377 ? 106.256 130.152 79.775  1.00 114.95 ? 369 CYS B CB    1 
ATOM   6847  S  SG    . CYS B 1 377 ? 106.997 131.720 79.268  1.00 120.42 ? 369 CYS B SG    1 
ATOM   6848  N  N     . TYR B 1 378 ? 103.774 128.463 80.761  1.00 116.74 ? 370 TYR B N     1 
ATOM   6849  C  CA    . TYR B 1 378 ? 103.212 127.234 81.310  1.00 115.22 ? 370 TYR B CA    1 
ATOM   6850  C  C     . TYR B 1 378 ? 101.688 127.274 81.366  1.00 120.61 ? 370 TYR B C     1 
ATOM   6851  O  O     . TYR B 1 378 ? 101.080 126.683 82.261  1.00 119.67 ? 370 TYR B O     1 
ATOM   6852  C  CB    . TYR B 1 378 ? 103.793 126.941 82.693  1.00 107.91 ? 370 TYR B CB    1 
ATOM   6853  C  CG    . TYR B 1 378 ? 103.680 128.070 83.693  1.00 110.36 ? 370 TYR B CG    1 
ATOM   6854  C  CD1   . TYR B 1 378 ? 102.542 128.223 84.472  1.00 114.31 ? 370 TYR B CD1   1 
ATOM   6855  C  CD2   . TYR B 1 378 ? 104.723 128.966 83.875  1.00 111.35 ? 370 TYR B CD2   1 
ATOM   6856  C  CE1   . TYR B 1 378 ? 102.440 129.247 85.393  1.00 118.54 ? 370 TYR B CE1   1 
ATOM   6857  C  CE2   . TYR B 1 378 ? 104.630 129.991 84.795  1.00 114.28 ? 370 TYR B CE2   1 
ATOM   6858  C  CZ    . TYR B 1 378 ? 103.487 130.128 85.550  1.00 118.53 ? 370 TYR B CZ    1 
ATOM   6859  O  OH    . TYR B 1 378 ? 103.391 131.149 86.467  1.00 121.37 ? 370 TYR B OH    1 
ATOM   6860  N  N     . ARG B 1 379 ? 101.061 127.973 80.415  1.00 123.78 ? 371 ARG B N     1 
ATOM   6861  C  CA    . ARG B 1 379 ? 99.603  127.987 80.339  1.00 124.61 ? 371 ARG B CA    1 
ATOM   6862  C  C     . ARG B 1 379 ? 99.033  126.581 80.203  1.00 122.68 ? 371 ARG B C     1 
ATOM   6863  O  O     . ARG B 1 379 ? 97.939  126.303 80.707  1.00 122.16 ? 371 ARG B O     1 
ATOM   6864  C  CB    . ARG B 1 379 ? 99.151  128.860 79.167  1.00 124.09 ? 371 ARG B CB    1 
ATOM   6865  C  CG    . ARG B 1 379 ? 97.661  129.171 79.147  1.00 129.62 ? 371 ARG B CG    1 
ATOM   6866  C  CD    . ARG B 1 379 ? 97.350  130.499 79.829  1.00 130.68 ? 371 ARG B CD    1 
ATOM   6867  N  NE    . ARG B 1 379 ? 97.729  130.507 81.237  1.00 131.75 ? 371 ARG B NE    1 
ATOM   6868  C  CZ    . ARG B 1 379 ? 96.927  130.151 82.231  1.00 130.16 ? 371 ARG B CZ    1 
ATOM   6869  N  NH1   . ARG B 1 379 ? 95.687  129.748 82.008  1.00 129.23 ? 371 ARG B NH1   1 
ATOM   6870  N  NH2   . ARG B 1 379 ? 97.381  130.199 83.480  1.00 127.03 ? 371 ARG B NH2   1 
ATOM   6871  N  N     . ASP B 1 380 ? 99.754  125.685 79.529  1.00 119.29 ? 372 ASP B N     1 
ATOM   6872  C  CA    . ASP B 1 380 ? 99.354  124.283 79.423  1.00 116.68 ? 372 ASP B CA    1 
ATOM   6873  C  C     . ASP B 1 380 ? 100.129 123.483 80.467  1.00 117.11 ? 372 ASP B C     1 
ATOM   6874  O  O     . ASP B 1 380 ? 101.152 122.852 80.190  1.00 116.77 ? 372 ASP B O     1 
ATOM   6875  C  CB    . ASP B 1 380 ? 99.593  123.765 78.010  1.00 114.84 ? 372 ASP B CB    1 
ATOM   6876  C  CG    . ASP B 1 380 ? 100.957 124.152 77.470  1.00 114.08 ? 372 ASP B CG    1 
ATOM   6877  O  OD1   . ASP B 1 380 ? 101.474 125.217 77.868  1.00 111.43 ? 372 ASP B OD1   1 
ATOM   6878  O  OD2   . ASP B 1 380 ? 101.511 123.392 76.649  1.00 113.55 ? 372 ASP B OD2   1 
ATOM   6879  N  N     . VAL B 1 381 ? 99.621  123.518 81.703  1.00 115.96 ? 373 VAL B N     1 
ATOM   6880  C  CA    . VAL B 1 381 ? 100.289 122.832 82.807  1.00 113.62 ? 373 VAL B CA    1 
ATOM   6881  C  C     . VAL B 1 381 ? 100.305 121.327 82.586  1.00 112.20 ? 373 VAL B C     1 
ATOM   6882  O  O     . VAL B 1 381 ? 101.163 120.621 83.130  1.00 110.62 ? 373 VAL B O     1 
ATOM   6883  C  CB    . VAL B 1 381 ? 99.622  123.195 84.149  1.00 109.29 ? 373 VAL B CB    1 
ATOM   6884  C  CG1   . VAL B 1 381 ? 99.804  124.673 84.453  1.00 109.45 ? 373 VAL B CG1   1 
ATOM   6885  C  CG2   . VAL B 1 381 ? 98.146  122.827 84.128  1.00 110.71 ? 373 VAL B CG2   1 
ATOM   6886  N  N     . SER B 1 382 ? 99.361  120.809 81.798  1.00 115.39 ? 374 SER B N     1 
ATOM   6887  C  CA    . SER B 1 382 ? 99.303  119.371 81.555  1.00 113.45 ? 374 SER B CA    1 
ATOM   6888  C  C     . SER B 1 382 ? 100.539 118.882 80.810  1.00 109.28 ? 374 SER B C     1 
ATOM   6889  O  O     . SER B 1 382 ? 101.012 117.764 81.045  1.00 107.23 ? 374 SER B O     1 
ATOM   6890  C  CB    . SER B 1 382 ? 98.035  119.022 80.778  1.00 117.03 ? 374 SER B CB    1 
ATOM   6891  O  OG    . SER B 1 382 ? 98.005  119.687 79.526  1.00 118.25 ? 374 SER B OG    1 
ATOM   6892  N  N     . ASP B 1 383 ? 101.074 119.702 79.909  1.00 109.48 ? 375 ASP B N     1 
ATOM   6893  C  CA    . ASP B 1 383 ? 102.200 119.325 79.061  1.00 107.57 ? 375 ASP B CA    1 
ATOM   6894  C  C     . ASP B 1 383 ? 103.481 120.055 79.457  1.00 100.19 ? 375 ASP B C     1 
ATOM   6895  O  O     . ASP B 1 383 ? 104.271 120.462 78.603  1.00 92.32  ? 375 ASP B O     1 
ATOM   6896  C  CB    . ASP B 1 383 ? 101.877 119.583 77.592  1.00 114.30 ? 375 ASP B CB    1 
ATOM   6897  C  CG    . ASP B 1 383 ? 100.717 118.743 77.095  1.00 119.32 ? 375 ASP B CG    1 
ATOM   6898  O  OD1   . ASP B 1 383 ? 99.562  119.047 77.461  1.00 121.65 ? 375 ASP B OD1   1 
ATOM   6899  O  OD2   . ASP B 1 383 ? 100.959 117.779 76.339  1.00 118.57 ? 375 ASP B OD2   1 
ATOM   6900  N  N     . LEU B 1 384 ? 103.699 120.233 80.757  1.00 101.28 ? 376 LEU B N     1 
ATOM   6901  C  CA    . LEU B 1 384 ? 104.944 120.814 81.241  1.00 93.85  ? 376 LEU B CA    1 
ATOM   6902  C  C     . LEU B 1 384 ? 105.977 119.718 81.466  1.00 84.29  ? 376 LEU B C     1 
ATOM   6903  O  O     . LEU B 1 384 ? 105.638 118.594 81.848  1.00 80.69  ? 376 LEU B O     1 
ATOM   6904  C  CB    . LEU B 1 384 ? 104.708 121.594 82.532  1.00 91.88  ? 376 LEU B CB    1 
ATOM   6905  C  CG    . LEU B 1 384 ? 105.559 122.857 82.649  1.00 82.51  ? 376 LEU B CG    1 
ATOM   6906  C  CD1   . LEU B 1 384 ? 105.268 123.779 81.479  1.00 87.12  ? 376 LEU B CD1   1 
ATOM   6907  C  CD2   . LEU B 1 384 ? 105.306 123.564 83.964  1.00 78.60  ? 376 LEU B CD2   1 
ATOM   6908  N  N     . LYS B 1 385 ? 107.247 120.047 81.227  1.00 79.48  ? 377 LYS B N     1 
ATOM   6909  C  CA    . LYS B 1 385 ? 108.304 119.045 81.169  1.00 74.45  ? 377 LYS B CA    1 
ATOM   6910  C  C     . LYS B 1 385 ? 109.350 119.204 82.266  1.00 72.75  ? 377 LYS B C     1 
ATOM   6911  O  O     . LYS B 1 385 ? 109.562 118.276 83.052  1.00 65.38  ? 377 LYS B O     1 
ATOM   6912  C  CB    . LYS B 1 385 ? 108.963 119.089 79.785  1.00 69.21  ? 377 LYS B CB    1 
ATOM   6913  C  CG    . LYS B 1 385 ? 108.016 118.705 78.662  1.00 74.11  ? 377 LYS B CG    1 
ATOM   6914  C  CD    . LYS B 1 385 ? 108.731 118.601 77.330  1.00 73.73  ? 377 LYS B CD    1 
ATOM   6915  C  CE    . LYS B 1 385 ? 107.785 118.126 76.240  1.00 75.67  ? 377 LYS B CE    1 
ATOM   6916  N  NZ    . LYS B 1 385 ? 108.469 117.991 74.926  1.00 80.63  ? 377 LYS B NZ    1 
ATOM   6917  N  N     . VAL B 1 386 ? 110.018 120.352 82.346  1.00 70.52  ? 378 VAL B N     1 
ATOM   6918  C  CA    . VAL B 1 386 ? 111.133 120.551 83.266  1.00 61.48  ? 378 VAL B CA    1 
ATOM   6919  C  C     . VAL B 1 386 ? 110.883 121.814 84.076  1.00 59.32  ? 378 VAL B C     1 
ATOM   6920  O  O     . VAL B 1 386 ? 110.576 122.869 83.511  1.00 61.92  ? 378 VAL B O     1 
ATOM   6921  C  CB    . VAL B 1 386 ? 112.476 120.642 82.519  1.00 61.64  ? 378 VAL B CB    1 
ATOM   6922  C  CG1   . VAL B 1 386 ? 113.596 121.010 83.474  1.00 60.14  ? 378 VAL B CG1   1 
ATOM   6923  C  CG2   . VAL B 1 386 ? 112.782 119.330 81.816  1.00 62.11  ? 378 VAL B CG2   1 
ATOM   6924  N  N     . ILE B 1 387 ? 111.029 121.708 85.395  1.00 55.04  ? 379 ILE B N     1 
ATOM   6925  C  CA    . ILE B 1 387 ? 110.746 122.796 86.322  1.00 53.00  ? 379 ILE B CA    1 
ATOM   6926  C  C     . ILE B 1 387 ? 112.037 123.177 87.030  1.00 51.80  ? 379 ILE B C     1 
ATOM   6927  O  O     . ILE B 1 387 ? 112.787 122.303 87.477  1.00 59.35  ? 379 ILE B O     1 
ATOM   6928  C  CB    . ILE B 1 387 ? 109.664 122.400 87.342  1.00 54.34  ? 379 ILE B CB    1 
ATOM   6929  C  CG1   . ILE B 1 387 ? 108.425 121.870 86.620  1.00 60.24  ? 379 ILE B CG1   1 
ATOM   6930  C  CG2   . ILE B 1 387 ? 109.306 123.581 88.222  1.00 58.47  ? 379 ILE B CG2   1 
ATOM   6931  C  CD1   . ILE B 1 387 ? 107.301 121.480 87.548  1.00 68.53  ? 379 ILE B CD1   1 
ATOM   6932  N  N     . HIS B 1 388 ? 112.297 124.476 87.126  1.00 50.48  ? 380 HIS B N     1 
ATOM   6933  C  CA    . HIS B 1 388 ? 113.465 124.996 87.824  1.00 52.36  ? 380 HIS B CA    1 
ATOM   6934  C  C     . HIS B 1 388 ? 112.993 125.750 89.060  1.00 55.69  ? 380 HIS B C     1 
ATOM   6935  O  O     . HIS B 1 388 ? 112.228 126.713 88.949  1.00 63.68  ? 380 HIS B O     1 
ATOM   6936  C  CB    . HIS B 1 388 ? 114.285 125.905 86.909  1.00 54.53  ? 380 HIS B CB    1 
ATOM   6937  C  CG    . HIS B 1 388 ? 115.615 126.294 87.472  1.00 54.35  ? 380 HIS B CG    1 
ATOM   6938  N  ND1   . HIS B 1 388 ? 116.462 127.175 86.836  1.00 57.00  ? 380 HIS B ND1   1 
ATOM   6939  C  CD2   . HIS B 1 388 ? 116.247 125.922 88.610  1.00 52.99  ? 380 HIS B CD2   1 
ATOM   6940  C  CE1   . HIS B 1 388 ? 117.557 127.331 87.558  1.00 59.35  ? 380 HIS B CE1   1 
ATOM   6941  N  NE2   . HIS B 1 388 ? 117.452 126.581 88.640  1.00 49.65  ? 380 HIS B NE2   1 
ATOM   6942  N  N     . TRP B 1 389 ? 113.444 125.311 90.230  1.00 57.96  ? 381 TRP B N     1 
ATOM   6943  C  CA    . TRP B 1 389 ? 113.043 125.920 91.498  1.00 61.07  ? 381 TRP B CA    1 
ATOM   6944  C  C     . TRP B 1 389 ? 114.086 126.937 91.955  1.00 67.81  ? 381 TRP B C     1 
ATOM   6945  O  O     . TRP B 1 389 ? 114.716 126.802 93.003  1.00 69.28  ? 381 TRP B O     1 
ATOM   6946  C  CB    . TRP B 1 389 ? 112.826 124.842 92.555  1.00 57.20  ? 381 TRP B CB    1 
ATOM   6947  C  CG    . TRP B 1 389 ? 111.968 123.714 92.092  1.00 56.44  ? 381 TRP B CG    1 
ATOM   6948  C  CD1   . TRP B 1 389 ? 112.380 122.581 91.460  1.00 57.14  ? 381 TRP B CD1   1 
ATOM   6949  C  CD2   . TRP B 1 389 ? 110.549 123.604 92.228  1.00 59.09  ? 381 TRP B CD2   1 
ATOM   6950  N  NE1   . TRP B 1 389 ? 111.306 121.771 91.191  1.00 57.95  ? 381 TRP B NE1   1 
ATOM   6951  C  CE2   . TRP B 1 389 ? 110.168 122.377 91.653  1.00 61.09  ? 381 TRP B CE2   1 
ATOM   6952  C  CE3   . TRP B 1 389 ? 109.562 124.425 92.780  1.00 61.35  ? 381 TRP B CE3   1 
ATOM   6953  C  CZ2   . TRP B 1 389 ? 108.845 121.951 91.612  1.00 65.02  ? 381 TRP B CZ2   1 
ATOM   6954  C  CZ3   . TRP B 1 389 ? 108.248 123.999 92.740  1.00 66.43  ? 381 TRP B CZ3   1 
ATOM   6955  C  CH2   . TRP B 1 389 ? 107.901 122.774 92.159  1.00 68.59  ? 381 TRP B CH2   1 
ATOM   6956  N  N     . ASN B 1 390 ? 114.260 127.978 91.143  1.00 66.93  ? 382 ASN B N     1 
ATOM   6957  C  CA    . ASN B 1 390 ? 115.227 129.028 91.427  1.00 73.41  ? 382 ASN B CA    1 
ATOM   6958  C  C     . ASN B 1 390 ? 114.655 130.129 92.312  1.00 87.40  ? 382 ASN B C     1 
ATOM   6959  O  O     . ASN B 1 390 ? 115.224 131.225 92.368  1.00 92.58  ? 382 ASN B O     1 
ATOM   6960  C  CB    . ASN B 1 390 ? 115.757 129.623 90.121  1.00 73.93  ? 382 ASN B CB    1 
ATOM   6961  C  CG    . ASN B 1 390 ? 114.649 130.086 89.200  1.00 80.33  ? 382 ASN B CG    1 
ATOM   6962  O  OD1   . ASN B 1 390 ? 113.525 129.590 89.265  1.00 81.16  ? 382 ASN B OD1   1 
ATOM   6963  N  ND2   . ASN B 1 390 ? 114.963 131.037 88.329  1.00 81.04  ? 382 ASN B ND2   1 
ATOM   6964  N  N     . SER B 1 391 ? 113.552 129.861 93.007  1.00 90.03  ? 383 SER B N     1 
ATOM   6965  C  CA    . SER B 1 391 ? 112.947 130.847 93.890  1.00 95.46  ? 383 SER B CA    1 
ATOM   6966  C  C     . SER B 1 391 ? 113.675 130.850 95.226  1.00 102.29 ? 383 SER B C     1 
ATOM   6967  O  O     . SER B 1 391 ? 113.736 129.804 95.886  1.00 105.09 ? 383 SER B O     1 
ATOM   6968  C  CB    . SER B 1 391 ? 111.475 130.546 94.104  1.00 95.48  ? 383 SER B CB    1 
ATOM   6969  O  OG    . SER B 1 391 ? 110.882 131.495 94.971  1.00 102.32 ? 383 SER B OG    1 
ATOM   6970  N  N     . PRO B 1 392 ? 114.240 131.985 95.663  1.00 105.30 ? 384 PRO B N     1 
ATOM   6971  C  CA    . PRO B 1 392 ? 114.943 132.089 96.947  1.00 104.90 ? 384 PRO B CA    1 
ATOM   6972  C  C     . PRO B 1 392 ? 114.027 131.821 98.137  1.00 105.43 ? 384 PRO B C     1 
ATOM   6973  O  O     . PRO B 1 392 ? 114.470 131.197 99.101  1.00 102.39 ? 384 PRO B O     1 
ATOM   6974  C  CB    . PRO B 1 392 ? 115.440 133.539 96.959  1.00 104.06 ? 384 PRO B CB    1 
ATOM   6975  C  CG    . PRO B 1 392 ? 115.469 133.947 95.524  1.00 104.10 ? 384 PRO B CG    1 
ATOM   6976  C  CD    . PRO B 1 392 ? 114.314 133.238 94.893  1.00 104.99 ? 384 PRO B CD    1 
ATOM   6977  N  N     . GLU B 1 403 ? 99.637  125.337 92.687  1.00 78.39  ? 395 GLU B N     1 
ATOM   6978  C  CA    . GLU B 1 403 ? 99.333  124.161 93.493  1.00 91.61  ? 395 GLU B CA    1 
ATOM   6979  C  C     . GLU B 1 403 ? 99.817  122.888 92.809  1.00 91.37  ? 395 GLU B C     1 
ATOM   6980  O  O     . GLU B 1 403 ? 100.312 121.965 93.465  1.00 94.37  ? 395 GLU B O     1 
ATOM   6981  C  CB    . GLU B 1 403 ? 97.831  124.074 93.769  1.00 94.07  ? 395 GLU B CB    1 
ATOM   6982  C  CG    . GLU B 1 403 ? 97.421  122.854 94.575  1.00 99.35  ? 395 GLU B CG    1 
ATOM   6983  C  CD    . GLU B 1 403 ? 95.942  122.840 94.901  1.00 106.26 ? 395 GLU B CD    1 
ATOM   6984  O  OE1   . GLU B 1 403 ? 95.310  123.915 94.847  1.00 109.01 ? 395 GLU B OE1   1 
ATOM   6985  O  OE2   . GLU B 1 403 ? 95.412  121.751 95.208  1.00 110.67 ? 395 GLU B OE2   1 
ATOM   6986  N  N     . PHE B 1 404 ? 99.671  122.844 91.483  1.00 87.36  ? 396 PHE B N     1 
ATOM   6987  C  CA    . PHE B 1 404 ? 100.153 121.692 90.730  1.00 91.40  ? 396 PHE B CA    1 
ATOM   6988  C  C     . PHE B 1 404 ? 101.663 121.547 90.857  1.00 89.66  ? 396 PHE B C     1 
ATOM   6989  O  O     . PHE B 1 404 ? 102.177 120.430 90.976  1.00 85.90  ? 396 PHE B O     1 
ATOM   6990  C  CB    . PHE B 1 404 ? 99.749  121.809 89.260  1.00 92.38  ? 396 PHE B CB    1 
ATOM   6991  C  CG    . PHE B 1 404 ? 100.292 120.706 88.396  1.00 97.08  ? 396 PHE B CG    1 
ATOM   6992  C  CD1   . PHE B 1 404 ? 99.693  119.458 88.386  1.00 97.41  ? 396 PHE B CD1   1 
ATOM   6993  C  CD2   . PHE B 1 404 ? 101.403 120.916 87.594  1.00 97.27  ? 396 PHE B CD2   1 
ATOM   6994  C  CE1   . PHE B 1 404 ? 100.191 118.441 87.594  1.00 96.49  ? 396 PHE B CE1   1 
ATOM   6995  C  CE2   . PHE B 1 404 ? 101.904 119.903 86.800  1.00 93.56  ? 396 PHE B CE2   1 
ATOM   6996  C  CZ    . PHE B 1 404 ? 101.298 118.665 86.800  1.00 93.35  ? 396 PHE B CZ    1 
ATOM   6997  N  N     . PHE B 1 405 ? 102.390 122.665 90.828  1.00 88.71  ? 397 PHE B N     1 
ATOM   6998  C  CA    . PHE B 1 405 ? 103.837 122.610 91.002  1.00 86.27  ? 397 PHE B CA    1 
ATOM   6999  C  C     . PHE B 1 405 ? 104.206 122.090 92.385  1.00 84.17  ? 397 PHE B C     1 
ATOM   7000  O  O     . PHE B 1 405 ? 105.135 121.288 92.528  1.00 83.38  ? 397 PHE B O     1 
ATOM   7001  C  CB    . PHE B 1 405 ? 104.448 123.990 90.765  1.00 82.86  ? 397 PHE B CB    1 
ATOM   7002  C  CG    . PHE B 1 405 ? 104.224 124.520 89.380  1.00 84.68  ? 397 PHE B CG    1 
ATOM   7003  C  CD1   . PHE B 1 405 ? 103.991 123.657 88.324  1.00 87.77  ? 397 PHE B CD1   1 
ATOM   7004  C  CD2   . PHE B 1 405 ? 104.245 125.881 89.134  1.00 86.69  ? 397 PHE B CD2   1 
ATOM   7005  C  CE1   . PHE B 1 405 ? 103.782 124.141 87.052  1.00 92.67  ? 397 PHE B CE1   1 
ATOM   7006  C  CE2   . PHE B 1 405 ? 104.038 126.372 87.862  1.00 93.50  ? 397 PHE B CE2   1 
ATOM   7007  C  CZ    . PHE B 1 405 ? 103.806 125.501 86.819  1.00 96.83  ? 397 PHE B CZ    1 
ATOM   7008  N  N     . ARG B 1 406 ? 103.486 122.537 93.416  1.00 86.83  ? 398 ARG B N     1 
ATOM   7009  C  CA    . ARG B 1 406 ? 103.752 122.057 94.768  1.00 87.22  ? 398 ARG B CA    1 
ATOM   7010  C  C     . ARG B 1 406 ? 103.501 120.558 94.877  1.00 84.68  ? 398 ARG B C     1 
ATOM   7011  O  O     . ARG B 1 406 ? 104.310 119.827 95.464  1.00 85.96  ? 398 ARG B O     1 
ATOM   7012  C  CB    . ARG B 1 406 ? 102.883 122.821 95.768  1.00 89.27  ? 398 ARG B CB    1 
ATOM   7013  C  CG    . ARG B 1 406 ? 103.480 122.950 97.160  1.00 98.64  ? 398 ARG B CG    1 
ATOM   7014  C  CD    . ARG B 1 406 ? 104.293 124.229 97.301  1.00 104.92 ? 398 ARG B CD    1 
ATOM   7015  N  NE    . ARG B 1 406 ? 104.865 124.362 98.636  1.00 116.35 ? 398 ARG B NE    1 
ATOM   7016  C  CZ    . ARG B 1 406 ? 105.415 125.472 99.111  1.00 118.34 ? 398 ARG B CZ    1 
ATOM   7017  N  NH1   . ARG B 1 406 ? 105.474 126.579 98.389  1.00 114.04 ? 398 ARG B NH1   1 
ATOM   7018  N  NH2   . ARG B 1 406 ? 105.914 125.471 100.344 1.00 120.92 ? 398 ARG B NH2   1 
ATOM   7019  N  N     . ASN B 1 407 ? 102.390 120.082 94.308  1.00 83.07  ? 399 ASN B N     1 
ATOM   7020  C  CA    . ASN B 1 407 ? 102.094 118.654 94.345  1.00 81.92  ? 399 ASN B CA    1 
ATOM   7021  C  C     . ASN B 1 407 ? 103.129 117.852 93.567  1.00 83.86  ? 399 ASN B C     1 
ATOM   7022  O  O     . ASN B 1 407 ? 103.546 116.774 94.003  1.00 84.65  ? 399 ASN B O     1 
ATOM   7023  C  CB    . ASN B 1 407 ? 100.690 118.394 93.803  1.00 85.22  ? 399 ASN B CB    1 
ATOM   7024  C  CG    . ASN B 1 407 ? 99.609  118.983 94.685  1.00 92.62  ? 399 ASN B CG    1 
ATOM   7025  O  OD1   . ASN B 1 407 ? 99.785  119.115 95.896  1.00 88.59  ? 399 ASN B OD1   1 
ATOM   7026  N  ND2   . ASN B 1 407 ? 98.482  119.341 94.082  1.00 99.38  ? 399 ASN B ND2   1 
ATOM   7027  N  N     . LEU B 1 408 ? 103.560 118.364 92.411  1.00 86.17  ? 400 LEU B N     1 
ATOM   7028  C  CA    . LEU B 1 408 ? 104.580 117.677 91.627  1.00 85.70  ? 400 LEU B CA    1 
ATOM   7029  C  C     . LEU B 1 408 ? 105.896 117.593 92.389  1.00 83.72  ? 400 LEU B C     1 
ATOM   7030  O  O     . LEU B 1 408 ? 106.568 116.556 92.370  1.00 79.08  ? 400 LEU B O     1 
ATOM   7031  C  CB    . LEU B 1 408 ? 104.770 118.391 90.287  1.00 81.45  ? 400 LEU B CB    1 
ATOM   7032  C  CG    . LEU B 1 408 ? 105.691 117.761 89.239  1.00 80.12  ? 400 LEU B CG    1 
ATOM   7033  C  CD1   . LEU B 1 408 ? 105.140 118.012 87.847  1.00 85.12  ? 400 LEU B CD1   1 
ATOM   7034  C  CD2   . LEU B 1 408 ? 107.105 118.307 89.351  1.00 77.17  ? 400 LEU B CD2   1 
ATOM   7035  N  N     . TYR B 1 409 ? 106.282 118.679 93.060  1.00 82.96  ? 401 TYR B N     1 
ATOM   7036  C  CA    . TYR B 1 409 ? 107.509 118.670 93.848  1.00 76.74  ? 401 TYR B CA    1 
ATOM   7037  C  C     . TYR B 1 409 ? 107.417 117.672 94.993  1.00 76.22  ? 401 TYR B C     1 
ATOM   7038  O  O     . TYR B 1 409 ? 108.352 116.901 95.238  1.00 73.61  ? 401 TYR B O     1 
ATOM   7039  C  CB    . TYR B 1 409 ? 107.796 120.074 94.375  1.00 76.28  ? 401 TYR B CB    1 
ATOM   7040  C  CG    . TYR B 1 409 ? 109.099 120.199 95.125  1.00 75.66  ? 401 TYR B CG    1 
ATOM   7041  C  CD1   . TYR B 1 409 ? 110.307 119.904 94.509  1.00 71.58  ? 401 TYR B CD1   1 
ATOM   7042  C  CD2   . TYR B 1 409 ? 109.123 120.629 96.444  1.00 77.73  ? 401 TYR B CD2   1 
ATOM   7043  C  CE1   . TYR B 1 409 ? 111.502 120.022 95.190  1.00 76.57  ? 401 TYR B CE1   1 
ATOM   7044  C  CE2   . TYR B 1 409 ? 110.313 120.752 97.133  1.00 76.81  ? 401 TYR B CE2   1 
ATOM   7045  C  CZ    . TYR B 1 409 ? 111.499 120.447 96.502  1.00 81.17  ? 401 TYR B CZ    1 
ATOM   7046  O  OH    . TYR B 1 409 ? 112.687 120.568 97.186  1.00 85.17  ? 401 TYR B OH    1 
ATOM   7047  N  N     . LEU B 1 410 ? 106.287 117.666 95.705  1.00 80.46  ? 402 LEU B N     1 
ATOM   7048  C  CA    . LEU B 1 410 ? 106.107 116.714 96.795  1.00 77.62  ? 402 LEU B CA    1 
ATOM   7049  C  C     . LEU B 1 410 ? 105.998 115.280 96.297  1.00 78.90  ? 402 LEU B C     1 
ATOM   7050  O  O     . LEU B 1 410 ? 106.222 114.349 97.078  1.00 78.50  ? 402 LEU B O     1 
ATOM   7051  C  CB    . LEU B 1 410 ? 104.868 117.075 97.615  1.00 77.86  ? 402 LEU B CB    1 
ATOM   7052  C  CG    . LEU B 1 410 ? 104.921 118.397 98.383  1.00 79.90  ? 402 LEU B CG    1 
ATOM   7053  C  CD1   . LEU B 1 410 ? 103.662 118.577 99.213  1.00 79.95  ? 402 LEU B CD1   1 
ATOM   7054  C  CD2   . LEU B 1 410 ? 106.160 118.464 99.261  1.00 77.65  ? 402 LEU B CD2   1 
ATOM   7055  N  N     . THR B 1 411 ? 105.644 115.082 95.026  1.00 79.29  ? 403 THR B N     1 
ATOM   7056  C  CA    . THR B 1 411 ? 105.571 113.732 94.478  1.00 77.93  ? 403 THR B CA    1 
ATOM   7057  C  C     . THR B 1 411 ? 106.937 113.058 94.491  1.00 77.43  ? 403 THR B C     1 
ATOM   7058  O  O     . THR B 1 411 ? 107.065 111.896 94.892  1.00 80.46  ? 403 THR B O     1 
ATOM   7059  C  CB    . THR B 1 411 ? 105.006 113.777 93.057  1.00 76.37  ? 403 THR B CB    1 
ATOM   7060  O  OG1   . THR B 1 411 ? 103.674 114.305 93.087  1.00 76.45  ? 403 THR B OG1   1 
ATOM   7061  C  CG2   . THR B 1 411 ? 104.983 112.385 92.445  1.00 76.97  ? 403 THR B CG2   1 
ATOM   7062  N  N     . PHE B 1 412 ? 107.974 113.777 94.064  1.00 75.78  ? 404 PHE B N     1 
ATOM   7063  C  CA    . PHE B 1 412 ? 109.317 113.215 94.033  1.00 74.15  ? 404 PHE B CA    1 
ATOM   7064  C  C     . PHE B 1 412 ? 110.073 113.426 95.334  1.00 72.75  ? 404 PHE B C     1 
ATOM   7065  O  O     . PHE B 1 412 ? 110.945 112.617 95.671  1.00 73.98  ? 404 PHE B O     1 
ATOM   7066  C  CB    . PHE B 1 412 ? 110.118 113.816 92.876  1.00 68.33  ? 404 PHE B CB    1 
ATOM   7067  C  CG    . PHE B 1 412 ? 109.449 113.674 91.543  1.00 68.49  ? 404 PHE B CG    1 
ATOM   7068  C  CD1   . PHE B 1 412 ? 109.343 112.435 90.938  1.00 67.70  ? 404 PHE B CD1   1 
ATOM   7069  C  CD2   . PHE B 1 412 ? 108.925 114.778 90.896  1.00 70.88  ? 404 PHE B CD2   1 
ATOM   7070  C  CE1   . PHE B 1 412 ? 108.725 112.300 89.713  1.00 71.18  ? 404 PHE B CE1   1 
ATOM   7071  C  CE2   . PHE B 1 412 ? 108.306 114.650 89.670  1.00 73.88  ? 404 PHE B CE2   1 
ATOM   7072  C  CZ    . PHE B 1 412 ? 108.206 113.409 89.078  1.00 74.76  ? 404 PHE B CZ    1 
ATOM   7073  N  N     . LEU B 1 413 ? 109.763 114.493 96.074  1.00 70.66  ? 405 LEU B N     1 
ATOM   7074  C  CA    . LEU B 1 413 ? 110.442 114.729 97.342  1.00 67.81  ? 405 LEU B CA    1 
ATOM   7075  C  C     . LEU B 1 413 ? 110.114 113.647 98.361  1.00 65.89  ? 405 LEU B C     1 
ATOM   7076  O  O     . LEU B 1 413 ? 110.887 113.423 99.299  1.00 64.76  ? 405 LEU B O     1 
ATOM   7077  C  CB    . LEU B 1 413 ? 110.067 116.108 97.884  1.00 70.28  ? 405 LEU B CB    1 
ATOM   7078  C  CG    . LEU B 1 413 ? 111.011 116.717 98.921  1.00 65.90  ? 405 LEU B CG    1 
ATOM   7079  C  CD1   . LEU B 1 413 ? 112.392 116.921 98.325  1.00 66.96  ? 405 LEU B CD1   1 
ATOM   7080  C  CD2   . LEU B 1 413 ? 110.456 118.028 99.449  1.00 66.55  ? 405 LEU B CD2   1 
ATOM   7081  N  N     . GLU B 1 414 ? 108.981 112.967 98.196  1.00 69.10  ? 406 GLU B N     1 
ATOM   7082  C  CA    . GLU B 1 414 ? 108.564 111.904 99.100  1.00 70.08  ? 406 GLU B CA    1 
ATOM   7083  C  C     . GLU B 1 414 ? 108.407 110.562 98.397  1.00 70.25  ? 406 GLU B C     1 
ATOM   7084  O  O     . GLU B 1 414 ? 107.832 109.635 98.975  1.00 73.87  ? 406 GLU B O     1 
ATOM   7085  C  CB    . GLU B 1 414 ? 107.256 112.285 99.795  1.00 73.51  ? 406 GLU B CB    1 
ATOM   7086  C  CG    . GLU B 1 414 ? 107.334 113.573 100.596 1.00 74.86  ? 406 GLU B CG    1 
ATOM   7087  C  CD    . GLU B 1 414 ? 106.052 113.869 101.346 1.00 83.00  ? 406 GLU B CD    1 
ATOM   7088  O  OE1   . GLU B 1 414 ? 105.095 113.075 101.227 1.00 84.73  ? 406 GLU B OE1   1 
ATOM   7089  O  OE2   . GLU B 1 414 ? 106.001 114.895 102.058 1.00 83.05  ? 406 GLU B OE2   1 
ATOM   7090  N  N     . TYR B 1 415 ? 108.896 110.435 97.166  1.00 69.09  ? 407 TYR B N     1 
ATOM   7091  C  CA    . TYR B 1 415 ? 108.800 109.178 96.439  1.00 73.26  ? 407 TYR B CA    1 
ATOM   7092  C  C     . TYR B 1 415 ? 109.810 108.172 96.974  1.00 72.48  ? 407 TYR B C     1 
ATOM   7093  O  O     . TYR B 1 415 ? 110.937 108.529 97.329  1.00 69.97  ? 407 TYR B O     1 
ATOM   7094  C  CB    . TYR B 1 415 ? 109.030 109.407 94.945  1.00 78.28  ? 407 TYR B CB    1 
ATOM   7095  C  CG    . TYR B 1 415 ? 108.873 108.164 94.100  1.00 85.84  ? 407 TYR B CG    1 
ATOM   7096  C  CD1   . TYR B 1 415 ? 107.621 107.608 93.876  1.00 86.27  ? 407 TYR B CD1   1 
ATOM   7097  C  CD2   . TYR B 1 415 ? 109.975 107.553 93.518  1.00 85.16  ? 407 TYR B CD2   1 
ATOM   7098  C  CE1   . TYR B 1 415 ? 107.472 106.474 93.102  1.00 89.20  ? 407 TYR B CE1   1 
ATOM   7099  C  CE2   . TYR B 1 415 ? 109.836 106.419 92.741  1.00 85.16  ? 407 TYR B CE2   1 
ATOM   7100  C  CZ    . TYR B 1 415 ? 108.582 105.884 92.537  1.00 89.94  ? 407 TYR B CZ    1 
ATOM   7101  O  OH    . TYR B 1 415 ? 108.438 104.755 91.764  1.00 91.37  ? 407 TYR B OH    1 
ATOM   7102  N  N     . ASP B 1 416 ? 109.400 106.908 97.026  1.00 71.95  ? 408 ASP B N     1 
ATOM   7103  C  CA    . ASP B 1 416 ? 110.276 105.850 97.513  1.00 72.13  ? 408 ASP B CA    1 
ATOM   7104  C  C     . ASP B 1 416 ? 111.325 105.521 96.457  1.00 74.72  ? 408 ASP B C     1 
ATOM   7105  O  O     . ASP B 1 416 ? 110.988 105.106 95.344  1.00 79.39  ? 408 ASP B O     1 
ATOM   7106  C  CB    . ASP B 1 416 ? 109.459 104.610 97.864  1.00 73.63  ? 408 ASP B CB    1 
ATOM   7107  C  CG    . ASP B 1 416 ? 110.294 103.524 98.509  1.00 77.63  ? 408 ASP B CG    1 
ATOM   7108  O  OD1   . ASP B 1 416 ? 111.440 103.811 98.915  1.00 78.40  ? 408 ASP B OD1   1 
ATOM   7109  O  OD2   . ASP B 1 416 ? 109.805 102.380 98.610  1.00 81.56  ? 408 ASP B OD2   1 
ATOM   7110  N  N     . GLY B 1 417 ? 112.600 105.701 96.809  1.00 67.75  ? 409 GLY B N     1 
ATOM   7111  C  CA    . GLY B 1 417 ? 113.663 105.453 95.852  1.00 63.06  ? 409 GLY B CA    1 
ATOM   7112  C  C     . GLY B 1 417 ? 113.889 103.984 95.567  1.00 64.46  ? 409 GLY B C     1 
ATOM   7113  O  O     . GLY B 1 417 ? 114.385 103.627 94.494  1.00 66.82  ? 409 GLY B O     1 
ATOM   7114  N  N     . ASN B 1 418 ? 113.526 103.111 96.509  1.00 64.81  ? 410 ASN B N     1 
ATOM   7115  C  CA    . ASN B 1 418 ? 113.704 101.680 96.299  1.00 65.15  ? 410 ASN B CA    1 
ATOM   7116  C  C     . ASN B 1 418 ? 112.799 101.141 95.201  1.00 73.14  ? 410 ASN B C     1 
ATOM   7117  O  O     . ASN B 1 418 ? 113.030 100.029 94.715  1.00 74.55  ? 410 ASN B O     1 
ATOM   7118  C  CB    . ASN B 1 418 ? 113.459 100.920 97.602  1.00 67.31  ? 410 ASN B CB    1 
ATOM   7119  C  CG    . ASN B 1 418 ? 114.392 101.357 98.711  1.00 72.66  ? 410 ASN B CG    1 
ATOM   7120  O  OD1   . ASN B 1 418 ? 115.437 101.955 98.457  1.00 71.28  ? 410 ASN B OD1   1 
ATOM   7121  N  ND2   . ASN B 1 418 ? 114.020 101.059 99.949  1.00 72.99  ? 410 ASN B ND2   1 
ATOM   7122  N  N     . LEU B 1 419 ? 111.776 101.897 94.801  1.00 77.83  ? 411 LEU B N     1 
ATOM   7123  C  CA    . LEU B 1 419 ? 110.975 101.519 93.646  1.00 74.93  ? 411 LEU B CA    1 
ATOM   7124  C  C     . LEU B 1 419 ? 111.739 101.668 92.339  1.00 70.31  ? 411 LEU B C     1 
ATOM   7125  O  O     . LEU B 1 419 ? 111.287 101.146 91.314  1.00 75.46  ? 411 LEU B O     1 
ATOM   7126  C  CB    . LEU B 1 419 ? 109.697 102.358 93.591  1.00 75.83  ? 411 LEU B CB    1 
ATOM   7127  C  CG    . LEU B 1 419 ? 108.810 102.330 94.836  1.00 80.09  ? 411 LEU B CG    1 
ATOM   7128  C  CD1   . LEU B 1 419 ? 107.530 103.114 94.594  1.00 76.47  ? 411 LEU B CD1   1 
ATOM   7129  C  CD2   . LEU B 1 419 ? 108.501 100.899 95.251  1.00 79.59  ? 411 LEU B CD2   1 
ATOM   7130  N  N     . LEU B 1 420 ? 112.876 102.359 92.351  1.00 68.79  ? 412 LEU B N     1 
ATOM   7131  C  CA    . LEU B 1 420 ? 113.694 102.536 91.160  1.00 73.36  ? 412 LEU B CA    1 
ATOM   7132  C  C     . LEU B 1 420 ? 114.633 101.365 90.907  1.00 73.79  ? 412 LEU B C     1 
ATOM   7133  O  O     . LEU B 1 420 ? 115.366 101.384 89.914  1.00 71.67  ? 412 LEU B O     1 
ATOM   7134  C  CB    . LEU B 1 420 ? 114.503 103.829 91.270  1.00 69.23  ? 412 LEU B CB    1 
ATOM   7135  C  CG    . LEU B 1 420 ? 113.677 105.095 91.493  1.00 72.18  ? 412 LEU B CG    1 
ATOM   7136  C  CD1   . LEU B 1 420 ? 114.580 106.305 91.645  1.00 67.01  ? 412 LEU B CD1   1 
ATOM   7137  C  CD2   . LEU B 1 420 ? 112.695 105.297 90.353  1.00 74.92  ? 412 LEU B CD2   1 
ATOM   7138  N  N     . ARG B 1 421 ? 114.632 100.354 91.774  1.00 73.11  ? 413 ARG B N     1 
ATOM   7139  C  CA    . ARG B 1 421 ? 115.497 99.196  91.595  1.00 73.58  ? 413 ARG B CA    1 
ATOM   7140  C  C     . ARG B 1 421 ? 114.868 98.185  90.644  1.00 78.35  ? 413 ARG B C     1 
ATOM   7141  O  O     . ARG B 1 421 ? 114.742 97.003  90.977  1.00 79.79  ? 413 ARG B O     1 
ATOM   7142  C  CB    . ARG B 1 421 ? 115.801 98.544  92.944  1.00 66.63  ? 413 ARG B CB    1 
ATOM   7143  C  CG    . ARG B 1 421 ? 116.620 99.419  93.875  1.00 63.47  ? 413 ARG B CG    1 
ATOM   7144  C  CD    . ARG B 1 421 ? 116.864 98.739  95.209  1.00 62.59  ? 413 ARG B CD    1 
ATOM   7145  N  NE    . ARG B 1 421 ? 117.775 99.509  96.047  1.00 59.39  ? 413 ARG B NE    1 
ATOM   7146  C  CZ    . ARG B 1 421 ? 118.131 99.168  97.277  1.00 60.07  ? 413 ARG B CZ    1 
ATOM   7147  N  NH1   . ARG B 1 421 ? 117.660 98.075  97.855  1.00 61.23  ? 413 ARG B NH1   1 
ATOM   7148  N  NH2   . ARG B 1 421 ? 118.981 99.942  97.944  1.00 56.70  ? 413 ARG B NH2   1 
ATOM   7149  N  N     . ARG B 1 422 ? 114.472 98.643  89.459  1.00 79.21  ? 414 ARG B N     1 
ATOM   7150  C  CA    . ARG B 1 422 ? 113.927 97.783  88.418  1.00 84.26  ? 414 ARG B CA    1 
ATOM   7151  C  C     . ARG B 1 422 ? 114.675 98.055  87.121  1.00 89.52  ? 414 ARG B C     1 
ATOM   7152  O  O     . ARG B 1 422 ? 114.856 99.214  86.737  1.00 88.01  ? 414 ARG B O     1 
ATOM   7153  C  CB    . ARG B 1 422 ? 112.423 98.012  88.236  1.00 83.36  ? 414 ARG B CB    1 
ATOM   7154  C  CG    . ARG B 1 422 ? 112.026 99.471  88.097  1.00 82.63  ? 414 ARG B CG    1 
ATOM   7155  C  CD    . ARG B 1 422 ? 110.541 99.615  87.818  1.00 88.78  ? 414 ARG B CD    1 
ATOM   7156  N  NE    . ARG B 1 422 ? 110.151 101.012 87.670  1.00 94.81  ? 414 ARG B NE    1 
ATOM   7157  C  CZ    . ARG B 1 422 ? 108.928 101.419 87.358  1.00 97.72  ? 414 ARG B CZ    1 
ATOM   7158  N  NH1   . ARG B 1 422 ? 107.947 100.558 87.147  1.00 101.65 ? 414 ARG B NH1   1 
ATOM   7159  N  NH2   . ARG B 1 422 ? 108.686 102.722 87.254  1.00 98.66  ? 414 ARG B NH2   1 
ATOM   7160  N  N     . GLU B 1 423 ? 115.111 96.989  86.456  1.00 91.71  ? 415 GLU B N     1 
ATOM   7161  C  CA    . GLU B 1 423 ? 115.931 97.138  85.263  1.00 93.79  ? 415 GLU B CA    1 
ATOM   7162  C  C     . GLU B 1 423 ? 115.110 97.675  84.097  1.00 94.80  ? 415 GLU B C     1 
ATOM   7163  O  O     . GLU B 1 423 ? 113.888 97.512  84.036  1.00 92.66  ? 415 GLU B O     1 
ATOM   7164  C  CB    . GLU B 1 423 ? 116.567 95.802  84.881  1.00 97.05  ? 415 GLU B CB    1 
ATOM   7165  C  CG    . GLU B 1 423 ? 117.505 95.239  85.936  1.00 104.60 ? 415 GLU B CG    1 
ATOM   7166  C  CD    . GLU B 1 423 ? 118.252 94.010  85.459  1.00 114.53 ? 415 GLU B CD    1 
ATOM   7167  O  OE1   . GLU B 1 423 ? 118.075 93.624  84.284  1.00 114.61 ? 415 GLU B OE1   1 
ATOM   7168  O  OE2   . GLU B 1 423 ? 119.017 93.431  86.258  1.00 114.64 ? 415 GLU B OE2   1 
ATOM   7169  N  N     . LEU B 1 424 ? 115.800 98.327  83.165  1.00 96.20  ? 416 LEU B N     1 
ATOM   7170  C  CA    . LEU B 1 424 ? 115.163 98.836  81.960  1.00 102.30 ? 416 LEU B CA    1 
ATOM   7171  C  C     . LEU B 1 424 ? 114.859 97.690  81.005  1.00 111.48 ? 416 LEU B C     1 
ATOM   7172  O  O     . LEU B 1 424 ? 115.733 96.869  80.706  1.00 113.25 ? 416 LEU B O     1 
ATOM   7173  C  CB    . LEU B 1 424 ? 116.057 99.870  81.277  1.00 96.63  ? 416 LEU B CB    1 
ATOM   7174  C  CG    . LEU B 1 424 ? 116.096 101.260 81.910  1.00 81.45  ? 416 LEU B CG    1 
ATOM   7175  C  CD1   . LEU B 1 424 ? 117.104 102.143 81.198  1.00 76.00  ? 416 LEU B CD1   1 
ATOM   7176  C  CD2   . LEU B 1 424 ? 114.714 101.886 81.871  1.00 78.06  ? 416 LEU B CD2   1 
ATOM   7177  N  N     . PHE B 1 425 ? 113.619 97.636  80.529  1.00 115.38 ? 417 PHE B N     1 
ATOM   7178  C  CA    . PHE B 1 425 ? 113.216 96.585  79.607  1.00 118.27 ? 417 PHE B CA    1 
ATOM   7179  C  C     . PHE B 1 425 ? 113.894 96.765  78.254  1.00 121.89 ? 417 PHE B C     1 
ATOM   7180  O  O     . PHE B 1 425 ? 113.982 97.877  77.726  1.00 120.13 ? 417 PHE B O     1 
ATOM   7181  C  CB    . PHE B 1 425 ? 111.695 96.580  79.441  1.00 118.81 ? 417 PHE B CB    1 
ATOM   7182  C  CG    . PHE B 1 425 ? 111.117 97.920  79.076  1.00 119.83 ? 417 PHE B CG    1 
ATOM   7183  C  CD1   . PHE B 1 425 ? 110.765 98.829  80.061  1.00 119.97 ? 417 PHE B CD1   1 
ATOM   7184  C  CD2   . PHE B 1 425 ? 110.917 98.268  77.750  1.00 119.38 ? 417 PHE B CD2   1 
ATOM   7185  C  CE1   . PHE B 1 425 ? 110.233 100.060 79.731  1.00 121.63 ? 417 PHE B CE1   1 
ATOM   7186  C  CE2   . PHE B 1 425 ? 110.385 99.498  77.413  1.00 118.19 ? 417 PHE B CE2   1 
ATOM   7187  C  CZ    . PHE B 1 425 ? 110.043 100.395 78.405  1.00 118.51 ? 417 PHE B CZ    1 
ATOM   7188  N  N     . GLY B 1 426 ? 114.387 95.660  77.700  1.00 125.24 ? 418 GLY B N     1 
ATOM   7189  C  CA    . GLY B 1 426 ? 115.007 95.672  76.393  1.00 130.07 ? 418 GLY B CA    1 
ATOM   7190  C  C     . GLY B 1 426 ? 116.442 96.149  76.358  1.00 133.49 ? 418 GLY B C     1 
ATOM   7191  O  O     . GLY B 1 426 ? 117.038 96.177  75.274  1.00 135.04 ? 418 GLY B O     1 
ATOM   7192  N  N     . CYS B 1 427 ? 117.020 96.523  77.499  1.00 130.32 ? 419 CYS B N     1 
ATOM   7193  C  CA    . CYS B 1 427 ? 118.388 97.010  77.550  1.00 129.90 ? 419 CYS B CA    1 
ATOM   7194  C  C     . CYS B 1 427 ? 119.161 96.216  78.597  1.00 130.20 ? 419 CYS B C     1 
ATOM   7195  O  O     . CYS B 1 427 ? 118.689 96.071  79.738  1.00 125.95 ? 419 CYS B O     1 
ATOM   7196  C  CB    . CYS B 1 427 ? 118.432 98.510  77.871  1.00 125.18 ? 419 CYS B CB    1 
ATOM   7197  S  SG    . CYS B 1 427 ? 117.427 99.540  76.773  1.00 125.76 ? 419 CYS B SG    1 
ATOM   7198  N  N     . PRO B 1 428 ? 120.335 95.686  78.256  1.00 133.77 ? 420 PRO B N     1 
ATOM   7199  C  CA    . PRO B 1 428 ? 121.111 94.914  79.237  1.00 132.13 ? 420 PRO B CA    1 
ATOM   7200  C  C     . PRO B 1 428 ? 121.652 95.809  80.342  1.00 129.98 ? 420 PRO B C     1 
ATOM   7201  O  O     . PRO B 1 428 ? 122.098 96.931  80.092  1.00 130.02 ? 420 PRO B O     1 
ATOM   7202  C  CB    . PRO B 1 428 ? 122.241 94.308  78.397  1.00 130.09 ? 420 PRO B CB    1 
ATOM   7203  C  CG    . PRO B 1 428 ? 122.387 95.244  77.242  1.00 131.48 ? 420 PRO B CG    1 
ATOM   7204  C  CD    . PRO B 1 428 ? 121.002 95.747  76.944  1.00 132.90 ? 420 PRO B CD    1 
ATOM   7205  N  N     . SER B 1 429 ? 121.605 95.303  81.572  1.00 126.69 ? 421 SER B N     1 
ATOM   7206  C  CA    . SER B 1 429 ? 122.135 96.031  82.715  1.00 123.43 ? 421 SER B CA    1 
ATOM   7207  C  C     . SER B 1 429 ? 123.561 95.589  83.016  1.00 123.02 ? 421 SER B C     1 
ATOM   7208  O  O     . SER B 1 429 ? 123.862 94.392  83.051  1.00 122.38 ? 421 SER B O     1 
ATOM   7209  C  CB    . SER B 1 429 ? 121.251 95.815  83.943  1.00 119.59 ? 421 SER B CB    1 
ATOM   7210  O  OG    . SER B 1 429 ? 121.204 94.445  84.301  1.00 122.22 ? 421 SER B OG    1 
ATOM   7211  N  N     . GLU B 1 430 ? 124.439 96.564  83.233  1.00 120.53 ? 422 GLU B N     1 
ATOM   7212  C  CA    . GLU B 1 430 ? 125.826 96.267  83.554  1.00 119.09 ? 422 GLU B CA    1 
ATOM   7213  C  C     . GLU B 1 430 ? 125.929 95.579  84.911  1.00 122.10 ? 422 GLU B C     1 
ATOM   7214  O  O     . GLU B 1 430 ? 125.165 95.861  85.838  1.00 121.69 ? 422 GLU B O     1 
ATOM   7215  C  CB    . GLU B 1 430 ? 126.662 97.546  83.550  1.00 117.56 ? 422 GLU B CB    1 
ATOM   7216  C  CG    . GLU B 1 430 ? 126.670 98.282  82.220  1.00 116.10 ? 422 GLU B CG    1 
ATOM   7217  C  CD    . GLU B 1 430 ? 127.495 99.553  82.265  1.00 108.19 ? 422 GLU B CD    1 
ATOM   7218  O  OE1   . GLU B 1 430 ? 128.128 99.816  83.309  1.00 104.55 ? 422 GLU B OE1   1 
ATOM   7219  O  OE2   . GLU B 1 430 ? 127.510 100.289 81.256  1.00 97.50  ? 422 GLU B OE2   1 
ATOM   7220  N  N     . ALA B 1 431 ? 126.890 94.665  85.020  1.00 121.49 ? 423 ALA B N     1 
ATOM   7221  C  CA    . ALA B 1 431 ? 127.068 93.869  86.229  1.00 118.91 ? 423 ALA B CA    1 
ATOM   7222  C  C     . ALA B 1 431 ? 127.854 94.673  87.258  1.00 117.22 ? 423 ALA B C     1 
ATOM   7223  O  O     . ALA B 1 431 ? 129.021 95.012  87.033  1.00 117.83 ? 423 ALA B O     1 
ATOM   7224  C  CB    . ALA B 1 431 ? 127.774 92.557  85.900  1.00 115.44 ? 423 ALA B CB    1 
ATOM   7225  N  N     . ASP B 1 432 ? 127.220 94.977  88.386  1.00 115.44 ? 424 ASP B N     1 
ATOM   7226  C  CA    . ASP B 1 432 ? 127.865 95.671  89.489  1.00 113.59 ? 424 ASP B CA    1 
ATOM   7227  C  C     . ASP B 1 432 ? 128.247 94.674  90.576  1.00 110.91 ? 424 ASP B C     1 
ATOM   7228  O  O     . ASP B 1 432 ? 127.542 93.691  90.817  1.00 110.02 ? 424 ASP B O     1 
ATOM   7229  C  CB    . ASP B 1 432 ? 126.950 96.754  90.066  1.00 112.31 ? 424 ASP B CB    1 
ATOM   7230  C  CG    . ASP B 1 432 ? 127.672 97.673  91.033  1.00 111.46 ? 424 ASP B CG    1 
ATOM   7231  O  OD1   . ASP B 1 432 ? 128.911 97.563  91.151  1.00 108.75 ? 424 ASP B OD1   1 
ATOM   7232  O  OD2   . ASP B 1 432 ? 127.000 98.506  91.676  1.00 112.02 ? 424 ASP B OD2   1 
ATOM   7233  N  N     . VAL B 1 433 ? 129.380 94.940  91.231  1.00 109.30 ? 425 VAL B N     1 
ATOM   7234  C  CA    . VAL B 1 433 ? 129.910 94.004  92.221  1.00 106.38 ? 425 VAL B CA    1 
ATOM   7235  C  C     . VAL B 1 433 ? 128.943 93.854  93.388  1.00 103.94 ? 425 VAL B C     1 
ATOM   7236  O  O     . VAL B 1 433 ? 128.638 92.738  93.826  1.00 103.80 ? 425 VAL B O     1 
ATOM   7237  C  CB    . VAL B 1 433 ? 131.301 94.460  92.697  1.00 105.14 ? 425 VAL B CB    1 
ATOM   7238  C  CG1   . VAL B 1 433 ? 131.852 93.489  93.730  1.00 103.09 ? 425 VAL B CG1   1 
ATOM   7239  C  CG2   . VAL B 1 433 ? 132.248 94.587  91.515  1.00 104.73 ? 425 VAL B CG2   1 
ATOM   7240  N  N     . ASN B 1 434 ? 128.445 94.977  93.911  1.00 103.05 ? 426 ASN B N     1 
ATOM   7241  C  CA    . ASN B 1 434 ? 127.535 94.922  95.050  1.00 103.07 ? 426 ASN B CA    1 
ATOM   7242  C  C     . ASN B 1 434 ? 126.224 94.236  94.685  1.00 103.13 ? 426 ASN B C     1 
ATOM   7243  O  O     . ASN B 1 434 ? 125.712 93.412  95.453  1.00 102.93 ? 426 ASN B O     1 
ATOM   7244  C  CB    . ASN B 1 434 ? 127.277 96.332  95.576  1.00 99.39  ? 426 ASN B CB    1 
ATOM   7245  C  CG    . ASN B 1 434 ? 128.556 97.062  95.929  1.00 98.40  ? 426 ASN B CG    1 
ATOM   7246  O  OD1   . ASN B 1 434 ? 129.456 96.496  96.549  1.00 101.81 ? 426 ASN B OD1   1 
ATOM   7247  N  ND2   . ASN B 1 434 ? 128.648 98.322  95.525  1.00 93.78  ? 426 ASN B ND2   1 
ATOM   7248  N  N     . SER B 1 435 ? 125.668 94.562  93.516  1.00 102.83 ? 427 SER B N     1 
ATOM   7249  C  CA    . SER B 1 435 ? 124.429 93.923  93.084  1.00 99.95  ? 427 SER B CA    1 
ATOM   7250  C  C     . SER B 1 435 ? 124.626 92.429  92.870  1.00 103.20 ? 427 SER B C     1 
ATOM   7251  O  O     . SER B 1 435 ? 123.768 91.622  93.247  1.00 106.94 ? 427 SER B O     1 
ATOM   7252  C  CB    . SER B 1 435 ? 123.914 94.583  91.807  1.00 105.09 ? 427 SER B CB    1 
ATOM   7253  O  OG    . SER B 1 435 ? 124.805 94.361  90.728  1.00 113.67 ? 427 SER B OG    1 
ATOM   7254  N  N     . GLU B 1 436 ? 125.751 92.040  92.263  1.00 101.30 ? 428 GLU B N     1 
ATOM   7255  C  CA    . GLU B 1 436 ? 126.029 90.622  92.064  1.00 103.60 ? 428 GLU B CA    1 
ATOM   7256  C  C     . GLU B 1 436 ? 126.165 89.894  93.394  1.00 102.43 ? 428 GLU B C     1 
ATOM   7257  O  O     . GLU B 1 436 ? 125.642 88.785  93.558  1.00 101.65 ? 428 GLU B O     1 
ATOM   7258  C  CB    . GLU B 1 436 ? 127.295 90.442  91.227  1.00 105.46 ? 428 GLU B CB    1 
ATOM   7259  C  CG    . GLU B 1 436 ? 127.093 90.635  89.735  1.00 107.92 ? 428 GLU B CG    1 
ATOM   7260  C  CD    . GLU B 1 436 ? 128.356 90.360  88.942  1.00 110.79 ? 428 GLU B CD    1 
ATOM   7261  O  OE1   . GLU B 1 436 ? 129.459 90.542  89.498  1.00 110.51 ? 428 GLU B OE1   1 
ATOM   7262  O  OE2   . GLU B 1 436 ? 128.245 89.954  87.766  1.00 111.02 ? 428 GLU B OE2   1 
ATOM   7263  N  N     . ASN B 1 437 ? 126.868 90.499  94.354  1.00 100.81 ? 429 ASN B N     1 
ATOM   7264  C  CA    . ASN B 1 437 ? 127.016 89.872  95.663  1.00 98.32  ? 429 ASN B CA    1 
ATOM   7265  C  C     . ASN B 1 437 ? 125.668 89.719  96.354  1.00 96.53  ? 429 ASN B C     1 
ATOM   7266  O  O     . ASN B 1 437 ? 125.379 88.668  96.940  1.00 95.49  ? 429 ASN B O     1 
ATOM   7267  C  CB    . ASN B 1 437 ? 127.974 90.686  96.532  1.00 97.11  ? 429 ASN B CB    1 
ATOM   7268  C  CG    . ASN B 1 437 ? 129.380 90.723  95.972  1.00 98.83  ? 429 ASN B CG    1 
ATOM   7269  O  OD1   . ASN B 1 437 ? 129.809 89.803  95.276  1.00 100.21 ? 429 ASN B OD1   1 
ATOM   7270  N  ND2   . ASN B 1 437 ? 130.108 91.791  96.273  1.00 98.73  ? 429 ASN B ND2   1 
ATOM   7271  N  N     . LEU B 1 438 ? 124.829 90.756  96.295  1.00 96.48  ? 430 LEU B N     1 
ATOM   7272  C  CA    . LEU B 1 438 ? 123.512 90.671  96.917  1.00 94.58  ? 430 LEU B CA    1 
ATOM   7273  C  C     . LEU B 1 438 ? 122.661 89.591  96.264  1.00 94.03  ? 430 LEU B C     1 
ATOM   7274  O  O     . LEU B 1 438 ? 121.996 88.811  96.957  1.00 96.37  ? 430 LEU B O     1 
ATOM   7275  C  CB    . LEU B 1 438 ? 122.808 92.025  96.847  1.00 91.88  ? 430 LEU B CB    1 
ATOM   7276  C  CG    . LEU B 1 438 ? 121.369 92.060  97.368  1.00 88.95  ? 430 LEU B CG    1 
ATOM   7277  C  CD1   . LEU B 1 438 ? 121.304 91.572  98.806  1.00 84.37  ? 430 LEU B CD1   1 
ATOM   7278  C  CD2   . LEU B 1 438 ? 120.788 93.459  97.250  1.00 83.22  ? 430 LEU B CD2   1 
ATOM   7279  N  N     . GLN B 1 439 ? 122.673 89.524  94.930  1.00 96.08  ? 431 GLN B N     1 
ATOM   7280  C  CA    . GLN B 1 439 ? 121.894 88.505  94.236  1.00 97.36  ? 431 GLN B CA    1 
ATOM   7281  C  C     . GLN B 1 439 ? 122.383 87.106  94.584  1.00 95.26  ? 431 GLN B C     1 
ATOM   7282  O  O     . GLN B 1 439 ? 121.575 86.203  94.829  1.00 97.03  ? 431 GLN B O     1 
ATOM   7283  C  CB    . GLN B 1 439 ? 121.951 88.732  92.726  1.00 105.47 ? 431 GLN B CB    1 
ATOM   7284  C  CG    . GLN B 1 439 ? 121.210 89.971  92.251  1.00 108.59 ? 431 GLN B CG    1 
ATOM   7285  C  CD    . GLN B 1 439 ? 121.338 90.188  90.755  1.00 113.19 ? 431 GLN B CD    1 
ATOM   7286  O  OE1   . GLN B 1 439 ? 121.967 89.396  90.053  1.00 115.90 ? 431 GLN B OE1   1 
ATOM   7287  N  NE2   . GLN B 1 439 ? 120.741 91.266  90.260  1.00 109.01 ? 431 GLN B NE2   1 
ATOM   7288  N  N     . LYS B 1 440 ? 123.703 86.909  94.623  1.00 95.05  ? 432 LYS B N     1 
ATOM   7289  C  CA    . LYS B 1 440 ? 124.249 85.599  94.960  1.00 96.71  ? 432 LYS B CA    1 
ATOM   7290  C  C     . LYS B 1 440 ? 123.872 85.195  96.380  1.00 97.00  ? 432 LYS B C     1 
ATOM   7291  O  O     . LYS B 1 440 ? 123.440 84.061  96.623  1.00 98.12  ? 432 LYS B O     1 
ATOM   7292  C  CB    . LYS B 1 440 ? 125.768 85.610  94.788  1.00 97.19  ? 432 LYS B CB    1 
ATOM   7293  C  CG    . LYS B 1 440 ? 126.454 84.321  95.204  1.00 96.32  ? 432 LYS B CG    1 
ATOM   7294  C  CD    . LYS B 1 440 ? 127.962 84.432  95.060  1.00 96.33  ? 432 LYS B CD    1 
ATOM   7295  C  CE    . LYS B 1 440 ? 128.654 83.145  95.475  1.00 95.12  ? 432 LYS B CE    1 
ATOM   7296  N  NZ    . LYS B 1 440 ? 130.135 83.247  95.355  1.00 88.84  ? 432 LYS B NZ    1 
ATOM   7297  N  N     . GLN B 1 441 ? 124.016 86.120  97.332  1.00 95.53  ? 433 GLN B N     1 
ATOM   7298  C  CA    . GLN B 1 441 ? 123.700 85.804  98.721  1.00 92.24  ? 433 GLN B CA    1 
ATOM   7299  C  C     . GLN B 1 441 ? 122.216 85.508  98.900  1.00 92.62  ? 433 GLN B C     1 
ATOM   7300  O  O     . GLN B 1 441 ? 121.849 84.584  99.634  1.00 93.50  ? 433 GLN B O     1 
ATOM   7301  C  CB    . GLN B 1 441 ? 124.143 86.947  99.631  1.00 89.46  ? 433 GLN B CB    1 
ATOM   7302  C  CG    . GLN B 1 441 ? 125.651 87.060  99.767  1.00 89.50  ? 433 GLN B CG    1 
ATOM   7303  C  CD    . GLN B 1 441 ? 126.076 88.259  100.588 1.00 93.30  ? 433 GLN B CD    1 
ATOM   7304  O  OE1   . GLN B 1 441 ? 125.362 89.258  100.664 1.00 92.64  ? 433 GLN B OE1   1 
ATOM   7305  N  NE2   . GLN B 1 441 ? 127.245 88.164  101.210 1.00 94.59  ? 433 GLN B NE2   1 
ATOM   7306  N  N     . LEU B 1 442 ? 121.347 86.276  98.238  1.00 93.35  ? 434 LEU B N     1 
ATOM   7307  C  CA    . LEU B 1 442 ? 119.917 86.007  98.339  1.00 92.67  ? 434 LEU B CA    1 
ATOM   7308  C  C     . LEU B 1 442 ? 119.543 84.695  97.663  1.00 95.14  ? 434 LEU B C     1 
ATOM   7309  O  O     . LEU B 1 442 ? 118.619 84.011  98.116  1.00 99.61  ? 434 LEU B O     1 
ATOM   7310  C  CB    . LEU B 1 442 ? 119.118 87.164  97.742  1.00 89.49  ? 434 LEU B CB    1 
ATOM   7311  C  CG    . LEU B 1 442 ? 119.135 88.464  98.548  1.00 87.16  ? 434 LEU B CG    1 
ATOM   7312  C  CD1   . LEU B 1 442 ? 118.267 89.521  97.888  1.00 86.79  ? 434 LEU B CD1   1 
ATOM   7313  C  CD2   . LEU B 1 442 ? 118.681 88.211  99.974  1.00 88.53  ? 434 LEU B CD2   1 
ATOM   7314  N  N     . SER B 1 443 ? 120.239 84.329  96.584  1.00 93.46  ? 435 SER B N     1 
ATOM   7315  C  CA    . SER B 1 443 ? 119.975 83.048  95.939  1.00 93.98  ? 435 SER B CA    1 
ATOM   7316  C  C     . SER B 1 443 ? 120.423 81.886  96.816  1.00 100.54 ? 435 SER B C     1 
ATOM   7317  O  O     . SER B 1 443 ? 119.794 80.822  96.814  1.00 104.56 ? 435 SER B O     1 
ATOM   7318  C  CB    . SER B 1 443 ? 120.668 82.994  94.579  1.00 96.31  ? 435 SER B CB    1 
ATOM   7319  O  OG    . SER B 1 443 ? 122.068 83.151  94.719  1.00 99.63  ? 435 SER B OG    1 
ATOM   7320  N  N     . GLU B 1 444 ? 121.513 82.068  97.568  1.00 100.63 ? 436 GLU B N     1 
ATOM   7321  C  CA    . GLU B 1 444 ? 121.968 81.012  98.467  1.00 98.11  ? 436 GLU B CA    1 
ATOM   7322  C  C     . GLU B 1 444 ? 120.960 80.740  99.576  1.00 96.64  ? 436 GLU B C     1 
ATOM   7323  O  O     . GLU B 1 444 ? 120.870 79.610  100.068 1.00 96.63  ? 436 GLU B O     1 
ATOM   7324  C  CB    . GLU B 1 444 ? 123.324 81.380  99.071  1.00 96.33  ? 436 GLU B CB    1 
ATOM   7325  C  CG    . GLU B 1 444 ? 124.463 81.432  98.071  1.00 98.94  ? 436 GLU B CG    1 
ATOM   7326  C  CD    . GLU B 1 444 ? 125.766 81.876  98.703  1.00 101.19 ? 436 GLU B CD    1 
ATOM   7327  O  OE1   . GLU B 1 444 ? 125.821 81.966  99.947  1.00 102.16 ? 436 GLU B OE1   1 
ATOM   7328  O  OE2   . GLU B 1 444 ? 126.733 82.138  97.957  1.00 100.21 ? 436 GLU B OE2   1 
ATOM   7329  N  N     . LEU B 1 445 ? 120.200 81.754  99.983  1.00 97.56  ? 437 LEU B N     1 
ATOM   7330  C  CA    . LEU B 1 445 ? 119.246 81.593  101.072 1.00 100.88 ? 437 LEU B CA    1 
ATOM   7331  C  C     . LEU B 1 445 ? 118.081 80.710  100.640 1.00 104.15 ? 437 LEU B C     1 
ATOM   7332  O  O     . LEU B 1 445 ? 117.572 80.835  99.523  1.00 106.13 ? 437 LEU B O     1 
ATOM   7333  C  CB    . LEU B 1 445 ? 118.733 82.956  101.532 1.00 100.05 ? 437 LEU B CB    1 
ATOM   7334  C  CG    . LEU B 1 445 ? 119.782 83.940  102.048 1.00 94.79  ? 437 LEU B CG    1 
ATOM   7335  C  CD1   . LEU B 1 445 ? 119.135 85.263  102.416 1.00 91.36  ? 437 LEU B CD1   1 
ATOM   7336  C  CD2   . LEU B 1 445 ? 120.532 83.357  103.234 1.00 91.41  ? 437 LEU B CD2   1 
ATOM   7337  N  N     . ASP B 1 446 ? 117.658 79.819  101.533 1.00 106.60 ? 438 ASP B N     1 
ATOM   7338  C  CA    . ASP B 1 446 ? 116.538 78.928  101.259 1.00 109.99 ? 438 ASP B CA    1 
ATOM   7339  C  C     . ASP B 1 446 ? 115.233 79.623  101.627 1.00 113.10 ? 438 ASP B C     1 
ATOM   7340  O  O     . ASP B 1 446 ? 115.059 80.066  102.767 1.00 116.95 ? 438 ASP B O     1 
ATOM   7341  C  CB    . ASP B 1 446 ? 116.694 77.625  102.039 1.00 114.78 ? 438 ASP B CB    1 
ATOM   7342  C  CG    . ASP B 1 446 ? 115.622 76.606  101.697 1.00 119.06 ? 438 ASP B CG    1 
ATOM   7343  O  OD1   . ASP B 1 446 ? 114.877 76.823  100.719 1.00 119.86 ? 438 ASP B OD1   1 
ATOM   7344  O  OD2   . ASP B 1 446 ? 115.525 75.585  102.410 1.00 118.67 ? 438 ASP B OD2   1 
ATOM   7345  N  N     . GLU B 1 447 ? 114.316 79.718  100.663 1.00 115.26 ? 439 GLU B N     1 
ATOM   7346  C  CA    . GLU B 1 447 ? 113.017 80.324  100.923 1.00 117.99 ? 439 GLU B CA    1 
ATOM   7347  C  C     . GLU B 1 447 ? 112.089 79.410  101.711 1.00 120.24 ? 439 GLU B C     1 
ATOM   7348  O  O     . GLU B 1 447 ? 111.120 79.898  102.304 1.00 117.96 ? 439 GLU B O     1 
ATOM   7349  C  CB    . GLU B 1 447 ? 112.347 80.723  99.607  1.00 118.18 ? 439 GLU B CB    1 
ATOM   7350  C  CG    . GLU B 1 447 ? 113.140 81.725  98.786  1.00 118.56 ? 439 GLU B CG    1 
ATOM   7351  C  CD    . GLU B 1 447 ? 112.401 82.171  97.541  1.00 126.14 ? 439 GLU B CD    1 
ATOM   7352  O  OE1   . GLU B 1 447 ? 111.203 81.843  97.409  1.00 127.01 ? 439 GLU B OE1   1 
ATOM   7353  O  OE2   . GLU B 1 447 ? 113.018 82.849  96.693  1.00 130.59 ? 439 GLU B OE2   1 
ATOM   7354  N  N     . ASP B 1 448 ? 112.356 78.102  101.730 1.00 123.32 ? 440 ASP B N     1 
ATOM   7355  C  CA    . ASP B 1 448 ? 111.525 77.186  102.502 1.00 124.19 ? 440 ASP B CA    1 
ATOM   7356  C  C     . ASP B 1 448 ? 111.788 77.290  103.997 1.00 124.54 ? 440 ASP B C     1 
ATOM   7357  O  O     . ASP B 1 448 ? 110.938 76.875  104.793 1.00 124.24 ? 440 ASP B O     1 
ATOM   7358  C  CB    . ASP B 1 448 ? 111.750 75.747  102.036 1.00 125.55 ? 440 ASP B CB    1 
ATOM   7359  C  CG    . ASP B 1 448 ? 111.304 75.520  100.606 1.00 131.03 ? 440 ASP B CG    1 
ATOM   7360  O  OD1   . ASP B 1 448 ? 110.377 76.224  100.153 1.00 131.70 ? 440 ASP B OD1   1 
ATOM   7361  O  OD2   . ASP B 1 448 ? 111.879 74.638  99.935  1.00 132.43 ? 440 ASP B OD2   1 
ATOM   7362  N  N     . ASP B 1 449 ? 112.938 77.828  104.394 1.00 123.62 ? 441 ASP B N     1 
ATOM   7363  C  CA    . ASP B 1 449 ? 113.239 77.996  105.808 1.00 119.75 ? 441 ASP B CA    1 
ATOM   7364  C  C     . ASP B 1 449 ? 112.309 79.034  106.424 1.00 118.68 ? 441 ASP B C     1 
ATOM   7365  O  O     . ASP B 1 449 ? 112.023 80.072  105.820 1.00 119.97 ? 441 ASP B O     1 
ATOM   7366  C  CB    . ASP B 1 449 ? 114.697 78.415  105.992 1.00 116.66 ? 441 ASP B CB    1 
ATOM   7367  C  CG    . ASP B 1 449 ? 115.205 78.167  107.400 1.00 116.51 ? 441 ASP B CG    1 
ATOM   7368  O  OD1   . ASP B 1 449 ? 114.381 78.119  108.338 1.00 118.78 ? 441 ASP B OD1   1 
ATOM   7369  O  OD2   . ASP B 1 449 ? 116.434 78.022  107.570 1.00 113.83 ? 441 ASP B OD2   1 
ATOM   7370  N  N     . LEU B 1 450 ? 111.836 78.746  107.638 1.00 116.99 ? 442 LEU B N     1 
ATOM   7371  C  CA    . LEU B 1 450 ? 110.908 79.649  108.309 1.00 115.05 ? 442 LEU B CA    1 
ATOM   7372  C  C     . LEU B 1 450 ? 111.555 80.978  108.676 1.00 111.98 ? 442 LEU B C     1 
ATOM   7373  O  O     . LEU B 1 450 ? 110.844 81.977  108.832 1.00 108.14 ? 442 LEU B O     1 
ATOM   7374  C  CB    . LEU B 1 450 ? 110.339 78.976  109.560 1.00 114.80 ? 442 LEU B CB    1 
ATOM   7375  C  CG    . LEU B 1 450 ? 109.102 79.620  110.190 1.00 114.33 ? 442 LEU B CG    1 
ATOM   7376  C  CD1   . LEU B 1 450 ? 107.951 79.653  109.196 1.00 108.71 ? 442 LEU B CD1   1 
ATOM   7377  C  CD2   . LEU B 1 450 ? 108.698 78.885  111.459 1.00 112.39 ? 442 LEU B CD2   1 
ATOM   7378  N  N     . CYS B 1 451 ? 112.881 81.017  108.807 1.00 112.48 ? 443 CYS B N     1 
ATOM   7379  C  CA    . CYS B 1 451 ? 113.610 82.238  109.124 1.00 109.73 ? 443 CYS B CA    1 
ATOM   7380  C  C     . CYS B 1 451 ? 114.175 82.912  107.877 1.00 105.56 ? 443 CYS B C     1 
ATOM   7381  O  O     . CYS B 1 451 ? 115.240 83.535  107.934 1.00 101.29 ? 443 CYS B O     1 
ATOM   7382  C  CB    . CYS B 1 451 ? 114.730 81.943  110.121 1.00 109.98 ? 443 CYS B CB    1 
ATOM   7383  S  SG    . CYS B 1 451 ? 115.955 80.747  109.541 1.00 114.68 ? 443 CYS B SG    1 
ATOM   7384  N  N     . TYR B 1 452 ? 113.477 82.790  106.745 1.00 107.40 ? 444 TYR B N     1 
ATOM   7385  C  CA    . TYR B 1 452 ? 113.965 83.379  105.502 1.00 104.18 ? 444 TYR B CA    1 
ATOM   7386  C  C     . TYR B 1 452 ? 114.030 84.897  105.593 1.00 99.59  ? 444 TYR B C     1 
ATOM   7387  O  O     . TYR B 1 452 ? 114.963 85.518  105.071 1.00 101.26 ? 444 TYR B O     1 
ATOM   7388  C  CB    . TYR B 1 452 ? 113.074 82.948  104.336 1.00 106.31 ? 444 TYR B CB    1 
ATOM   7389  C  CG    . TYR B 1 452 ? 113.342 83.693  103.047 1.00 110.33 ? 444 TYR B CG    1 
ATOM   7390  C  CD1   . TYR B 1 452 ? 114.454 83.399  102.270 1.00 110.18 ? 444 TYR B CD1   1 
ATOM   7391  C  CD2   . TYR B 1 452 ? 112.479 84.686  102.603 1.00 107.49 ? 444 TYR B CD2   1 
ATOM   7392  C  CE1   . TYR B 1 452 ? 114.702 84.077  101.091 1.00 108.17 ? 444 TYR B CE1   1 
ATOM   7393  C  CE2   . TYR B 1 452 ? 112.718 85.369  101.427 1.00 104.39 ? 444 TYR B CE2   1 
ATOM   7394  C  CZ    . TYR B 1 452 ? 113.831 85.060  100.675 1.00 106.60 ? 444 TYR B CZ    1 
ATOM   7395  O  OH    . TYR B 1 452 ? 114.072 85.737  99.503  1.00 106.88 ? 444 TYR B OH    1 
ATOM   7396  N  N     . GLU B 1 453 ? 113.043 85.513  106.247 1.00 96.76  ? 445 GLU B N     1 
ATOM   7397  C  CA    . GLU B 1 453 ? 112.983 86.970  106.302 1.00 97.24  ? 445 GLU B CA    1 
ATOM   7398  C  C     . GLU B 1 453 ? 114.188 87.554  107.031 1.00 95.59  ? 445 GLU B C     1 
ATOM   7399  O  O     . GLU B 1 453 ? 114.767 88.552  106.586 1.00 96.01  ? 445 GLU B O     1 
ATOM   7400  C  CB    . GLU B 1 453 ? 111.682 87.409  106.971 1.00 101.04 ? 445 GLU B CB    1 
ATOM   7401  C  CG    . GLU B 1 453 ? 110.431 86.869  106.298 1.00 103.77 ? 445 GLU B CG    1 
ATOM   7402  C  CD    . GLU B 1 453 ? 109.166 87.202  107.065 1.00 110.99 ? 445 GLU B CD    1 
ATOM   7403  O  OE1   . GLU B 1 453 ? 109.268 87.832  108.138 1.00 109.89 ? 445 GLU B OE1   1 
ATOM   7404  O  OE2   . GLU B 1 453 ? 108.070 86.832  106.594 1.00 112.96 ? 445 GLU B OE2   1 
ATOM   7405  N  N     . PHE B 1 454 ? 114.584 86.945  108.150 1.00 94.86  ? 446 PHE B N     1 
ATOM   7406  C  CA    . PHE B 1 454 ? 115.712 87.465  108.918 1.00 92.66  ? 446 PHE B CA    1 
ATOM   7407  C  C     . PHE B 1 454 ? 117.021 87.335  108.149 1.00 91.72  ? 446 PHE B C     1 
ATOM   7408  O  O     . PHE B 1 454 ? 117.825 88.275  108.113 1.00 91.67  ? 446 PHE B O     1 
ATOM   7409  C  CB    . PHE B 1 454 ? 115.804 86.744  110.261 1.00 92.77  ? 446 PHE B CB    1 
ATOM   7410  C  CG    . PHE B 1 454 ? 114.595 86.929  111.125 1.00 95.48  ? 446 PHE B CG    1 
ATOM   7411  C  CD1   . PHE B 1 454 ? 113.507 86.081  111.008 1.00 98.79  ? 446 PHE B CD1   1 
ATOM   7412  C  CD2   . PHE B 1 454 ? 114.542 87.956  112.048 1.00 94.97  ? 446 PHE B CD2   1 
ATOM   7413  C  CE1   . PHE B 1 454 ? 112.391 86.254  111.797 1.00 98.94  ? 446 PHE B CE1   1 
ATOM   7414  C  CE2   . PHE B 1 454 ? 113.430 88.131  112.840 1.00 94.84  ? 446 PHE B CE2   1 
ATOM   7415  C  CZ    . PHE B 1 454 ? 112.353 87.278  112.716 1.00 97.01  ? 446 PHE B CZ    1 
ATOM   7416  N  N     . ARG B 1 455 ? 117.253 86.179  107.526 1.00 87.95  ? 447 ARG B N     1 
ATOM   7417  C  CA    . ARG B 1 455 ? 118.471 85.998  106.747 1.00 85.15  ? 447 ARG B CA    1 
ATOM   7418  C  C     . ARG B 1 455 ? 118.500 86.941  105.552 1.00 85.31  ? 447 ARG B C     1 
ATOM   7419  O  O     . ARG B 1 455 ? 119.559 87.468  105.193 1.00 82.97  ? 447 ARG B O     1 
ATOM   7420  C  CB    . ARG B 1 455 ? 118.594 84.544  106.300 1.00 91.61  ? 447 ARG B CB    1 
ATOM   7421  C  CG    . ARG B 1 455 ? 118.503 83.551  107.446 1.00 92.66  ? 447 ARG B CG    1 
ATOM   7422  C  CD    . ARG B 1 455 ? 118.691 82.125  106.964 1.00 96.50  ? 447 ARG B CD    1 
ATOM   7423  N  NE    . ARG B 1 455 ? 118.436 81.156  108.023 1.00 100.18 ? 447 ARG B NE    1 
ATOM   7424  C  CZ    . ARG B 1 455 ? 119.338 80.761  108.911 1.00 100.38 ? 447 ARG B CZ    1 
ATOM   7425  N  NH1   . ARG B 1 455 ? 120.571 81.240  108.903 1.00 98.72  ? 447 ARG B NH1   1 
ATOM   7426  N  NH2   . ARG B 1 455 ? 118.993 79.864  109.831 1.00 103.17 ? 447 ARG B NH2   1 
ATOM   7427  N  N     . ARG B 1 456 ? 117.343 87.166  104.923 1.00 88.35  ? 448 ARG B N     1 
ATOM   7428  C  CA    . ARG B 1 456 ? 117.269 88.129  103.830 1.00 86.25  ? 448 ARG B CA    1 
ATOM   7429  C  C     . ARG B 1 456 ? 117.598 89.535  104.313 1.00 83.51  ? 448 ARG B C     1 
ATOM   7430  O  O     . ARG B 1 456 ? 118.331 90.274  103.645 1.00 84.93  ? 448 ARG B O     1 
ATOM   7431  C  CB    . ARG B 1 456 ? 115.878 88.092  103.198 1.00 91.11  ? 448 ARG B CB    1 
ATOM   7432  C  CG    . ARG B 1 456 ? 115.679 89.087  102.070 1.00 93.45  ? 448 ARG B CG    1 
ATOM   7433  C  CD    . ARG B 1 456 ? 114.217 89.167  101.665 1.00 99.86  ? 448 ARG B CD    1 
ATOM   7434  N  NE    . ARG B 1 456 ? 113.372 89.565  102.785 1.00 109.93 ? 448 ARG B NE    1 
ATOM   7435  C  CZ    . ARG B 1 456 ? 112.062 89.756  102.707 1.00 111.77 ? 448 ARG B CZ    1 
ATOM   7436  N  NH1   . ARG B 1 456 ? 111.407 89.598  101.568 1.00 116.64 ? 448 ARG B NH1   1 
ATOM   7437  N  NH2   . ARG B 1 456 ? 111.393 90.114  103.799 1.00 98.94  ? 448 ARG B NH2   1 
ATOM   7438  N  N     . GLU B 1 457 ? 117.065 89.921  105.474 1.00 83.62  ? 449 GLU B N     1 
ATOM   7439  C  CA    . GLU B 1 457 ? 117.336 91.250  106.011 1.00 82.01  ? 449 GLU B CA    1 
ATOM   7440  C  C     . GLU B 1 457 ? 118.793 91.400  106.431 1.00 79.31  ? 449 GLU B C     1 
ATOM   7441  O  O     . GLU B 1 457 ? 119.314 92.521  106.462 1.00 78.41  ? 449 GLU B O     1 
ATOM   7442  C  CB    . GLU B 1 457 ? 116.409 91.532  107.194 1.00 83.52  ? 449 GLU B CB    1 
ATOM   7443  C  CG    . GLU B 1 457 ? 116.395 92.981  107.657 1.00 82.65  ? 449 GLU B CG    1 
ATOM   7444  C  CD    . GLU B 1 457 ? 115.616 93.887  106.724 1.00 81.51  ? 449 GLU B CD    1 
ATOM   7445  O  OE1   . GLU B 1 457 ? 114.866 93.364  105.872 1.00 81.54  ? 449 GLU B OE1   1 
ATOM   7446  O  OE2   . GLU B 1 457 ? 115.751 95.123  106.843 1.00 77.70  ? 449 GLU B OE2   1 
ATOM   7447  N  N     . ARG B 1 458 ? 119.458 90.292  106.764 1.00 75.11  ? 450 ARG B N     1 
ATOM   7448  C  CA    . ARG B 1 458 ? 120.858 90.366  107.175 1.00 70.98  ? 450 ARG B CA    1 
ATOM   7449  C  C     . ARG B 1 458 ? 121.737 90.935  106.067 1.00 73.15  ? 450 ARG B C     1 
ATOM   7450  O  O     . ARG B 1 458 ? 122.555 91.831  106.305 1.00 70.96  ? 450 ARG B O     1 
ATOM   7451  C  CB    . ARG B 1 458 ? 121.359 88.983  107.589 1.00 68.88  ? 450 ARG B CB    1 
ATOM   7452  C  CG    . ARG B 1 458 ? 122.867 88.918  107.762 1.00 69.66  ? 450 ARG B CG    1 
ATOM   7453  C  CD    . ARG B 1 458 ? 123.338 87.505  108.049 1.00 73.52  ? 450 ARG B CD    1 
ATOM   7454  N  NE    . ARG B 1 458 ? 124.790 87.437  108.165 1.00 75.59  ? 450 ARG B NE    1 
ATOM   7455  C  CZ    . ARG B 1 458 ? 125.468 86.331  108.436 1.00 79.61  ? 450 ARG B CZ    1 
ATOM   7456  N  NH1   . ARG B 1 458 ? 124.856 85.174  108.626 1.00 81.32  ? 450 ARG B NH1   1 
ATOM   7457  N  NH2   . ARG B 1 458 ? 126.794 86.388  108.519 1.00 81.69  ? 450 ARG B NH2   1 
ATOM   7458  N  N     . PHE B 1 459 ? 121.584 90.429  104.847 1.00 76.08  ? 451 PHE B N     1 
ATOM   7459  C  CA    . PHE B 1 459 ? 122.407 90.859  103.724 1.00 72.41  ? 451 PHE B CA    1 
ATOM   7460  C  C     . PHE B 1 459 ? 121.778 91.987  102.920 1.00 71.21  ? 451 PHE B C     1 
ATOM   7461  O  O     . PHE B 1 459 ? 122.394 92.456  101.958 1.00 71.51  ? 451 PHE B O     1 
ATOM   7462  C  CB    . PHE B 1 459 ? 122.698 89.675  102.797 1.00 74.63  ? 451 PHE B CB    1 
ATOM   7463  C  CG    . PHE B 1 459 ? 123.425 88.548  103.466 1.00 77.23  ? 451 PHE B CG    1 
ATOM   7464  C  CD1   . PHE B 1 459 ? 124.770 88.659  103.770 1.00 80.56  ? 451 PHE B CD1   1 
ATOM   7465  C  CD2   . PHE B 1 459 ? 122.766 87.375  103.786 1.00 79.84  ? 451 PHE B CD2   1 
ATOM   7466  C  CE1   . PHE B 1 459 ? 125.444 87.625  104.385 1.00 84.82  ? 451 PHE B CE1   1 
ATOM   7467  C  CE2   . PHE B 1 459 ? 123.434 86.336  104.401 1.00 83.55  ? 451 PHE B CE2   1 
ATOM   7468  C  CZ    . PHE B 1 459 ? 124.775 86.461  104.701 1.00 84.54  ? 451 PHE B CZ    1 
ATOM   7469  N  N     . THR B 1 460 ? 120.576 92.427  103.285 1.00 70.96  ? 452 THR B N     1 
ATOM   7470  C  CA    . THR B 1 460 ? 119.914 93.498  102.553 1.00 66.61  ? 452 THR B CA    1 
ATOM   7471  C  C     . THR B 1 460 ? 120.740 94.775  102.616 1.00 65.20  ? 452 THR B C     1 
ATOM   7472  O  O     . THR B 1 460 ? 121.210 95.175  103.684 1.00 68.81  ? 452 THR B O     1 
ATOM   7473  C  CB    . THR B 1 460 ? 118.517 93.740  103.127 1.00 70.63  ? 452 THR B CB    1 
ATOM   7474  O  OG1   . THR B 1 460 ? 117.688 92.601  102.868 1.00 76.17  ? 452 THR B OG1   1 
ATOM   7475  C  CG2   . THR B 1 460 ? 117.884 94.973  102.505 1.00 69.38  ? 452 THR B CG2   1 
ATOM   7476  N  N     . VAL B 1 461 ? 120.920 95.412  101.463 1.00 64.47  ? 453 VAL B N     1 
ATOM   7477  C  CA    . VAL B 1 461 ? 121.655 96.665  101.361 1.00 62.37  ? 453 VAL B CA    1 
ATOM   7478  C  C     . VAL B 1 461 ? 120.645 97.803  101.374 1.00 61.52  ? 453 VAL B C     1 
ATOM   7479  O  O     . VAL B 1 461 ? 119.757 97.866  100.516 1.00 60.39  ? 453 VAL B O     1 
ATOM   7480  C  CB    . VAL B 1 461 ? 122.524 96.706  100.096 1.00 62.58  ? 453 VAL B CB    1 
ATOM   7481  C  CG1   . VAL B 1 461 ? 123.168 98.071  99.943  1.00 57.54  ? 453 VAL B CG1   1 
ATOM   7482  C  CG2   . VAL B 1 461 ? 123.584 95.621  100.158 1.00 68.79  ? 453 VAL B CG2   1 
ATOM   7483  N  N     . HIS B 1 462 ? 120.781 98.698  102.345 1.00 61.37  ? 454 HIS B N     1 
ATOM   7484  C  CA    . HIS B 1 462 ? 119.849 99.800  102.536 1.00 56.27  ? 454 HIS B CA    1 
ATOM   7485  C  C     . HIS B 1 462 ? 120.461 101.087 102.005 1.00 49.74  ? 454 HIS B C     1 
ATOM   7486  O  O     . HIS B 1 462 ? 121.627 101.387 102.284 1.00 51.95  ? 454 HIS B O     1 
ATOM   7487  C  CB    . HIS B 1 462 ? 119.491 99.959  104.013 1.00 55.10  ? 454 HIS B CB    1 
ATOM   7488  C  CG    . HIS B 1 462 ? 118.705 98.816  104.573 1.00 60.41  ? 454 HIS B CG    1 
ATOM   7489  N  ND1   . HIS B 1 462 ? 117.362 98.909  104.864 1.00 62.94  ? 454 HIS B ND1   1 
ATOM   7490  C  CD2   . HIS B 1 462 ? 119.074 97.554  104.898 1.00 61.42  ? 454 HIS B CD2   1 
ATOM   7491  C  CE1   . HIS B 1 462 ? 116.936 97.754  105.343 1.00 66.14  ? 454 HIS B CE1   1 
ATOM   7492  N  NE2   . HIS B 1 462 ? 117.955 96.915  105.374 1.00 66.43  ? 454 HIS B NE2   1 
ATOM   7493  N  N     . ARG B 1 463 ? 119.675 101.839 101.241 1.00 44.70  ? 455 ARG B N     1 
ATOM   7494  C  CA    . ARG B 1 463 ? 120.132 103.116 100.712 1.00 40.67  ? 455 ARG B CA    1 
ATOM   7495  C  C     . ARG B 1 463 ? 120.465 104.067 101.853 1.00 41.13  ? 455 ARG B C     1 
ATOM   7496  O  O     . ARG B 1 463 ? 119.593 104.428 102.648 1.00 43.29  ? 455 ARG B O     1 
ATOM   7497  C  CB    . ARG B 1 463 ? 119.058 103.712 99.804  1.00 40.74  ? 455 ARG B CB    1 
ATOM   7498  C  CG    . ARG B 1 463 ? 119.344 105.121 99.327  1.00 39.69  ? 455 ARG B CG    1 
ATOM   7499  C  CD    . ARG B 1 463 ? 118.424 105.491 98.179  1.00 43.46  ? 455 ARG B CD    1 
ATOM   7500  N  NE    . ARG B 1 463 ? 117.035 105.151 98.461  1.00 49.76  ? 455 ARG B NE    1 
ATOM   7501  C  CZ    . ARG B 1 463 ? 116.106 106.027 98.818  1.00 49.91  ? 455 ARG B CZ    1 
ATOM   7502  N  NH1   . ARG B 1 463 ? 116.379 107.315 98.935  1.00 44.72  ? 455 ARG B NH1   1 
ATOM   7503  N  NH2   . ARG B 1 463 ? 114.871 105.599 99.060  1.00 51.49  ? 455 ARG B NH2   1 
ATOM   7504  N  N     . THR B 1 464 ? 121.729 104.468 101.934 1.00 38.61  ? 456 THR B N     1 
ATOM   7505  C  CA    . THR B 1 464 ? 122.234 105.271 103.038 1.00 35.73  ? 456 THR B CA    1 
ATOM   7506  C  C     . THR B 1 464 ? 122.614 106.657 102.538 1.00 34.86  ? 456 THR B C     1 
ATOM   7507  O  O     . THR B 1 464 ? 123.326 106.787 101.538 1.00 33.47  ? 456 THR B O     1 
ATOM   7508  C  CB    . THR B 1 464 ? 123.442 104.600 103.694 1.00 36.25  ? 456 THR B CB    1 
ATOM   7509  O  OG1   . THR B 1 464 ? 123.089 103.273 104.100 1.00 41.22  ? 456 THR B OG1   1 
ATOM   7510  C  CG2   . THR B 1 464 ? 123.893 105.389 104.910 1.00 37.57  ? 456 THR B CG2   1 
ATOM   7511  N  N     . HIS B 1 465 ? 122.144 107.683 103.239 1.00 36.93  ? 457 HIS B N     1 
ATOM   7512  C  CA    . HIS B 1 465 ? 122.423 109.077 102.904 1.00 35.37  ? 457 HIS B CA    1 
ATOM   7513  C  C     . HIS B 1 465 ? 123.205 109.683 104.064 1.00 31.20  ? 457 HIS B C     1 
ATOM   7514  O  O     . HIS B 1 465 ? 122.616 110.151 105.042 1.00 31.40  ? 457 HIS B O     1 
ATOM   7515  C  CB    . HIS B 1 465 ? 121.128 109.837 102.631 1.00 34.72  ? 457 HIS B CB    1 
ATOM   7516  C  CG    . HIS B 1 465 ? 121.331 111.188 102.022 1.00 35.58  ? 457 HIS B CG    1 
ATOM   7517  N  ND1   . HIS B 1 465 ? 120.473 111.714 101.080 1.00 34.32  ? 457 HIS B ND1   1 
ATOM   7518  C  CD2   . HIS B 1 465 ? 122.286 112.126 102.224 1.00 35.81  ? 457 HIS B CD2   1 
ATOM   7519  C  CE1   . HIS B 1 465 ? 120.895 112.914 100.725 1.00 36.02  ? 457 HIS B CE1   1 
ATOM   7520  N  NE2   . HIS B 1 465 ? 121.993 113.188 101.405 1.00 35.12  ? 457 HIS B NE2   1 
ATOM   7521  N  N     . LEU B 1 466 ? 124.529 109.673 103.953 1.00 29.63  ? 458 LEU B N     1 
ATOM   7522  C  CA    . LEU B 1 466 ? 125.376 110.198 105.015 1.00 30.53  ? 458 LEU B CA    1 
ATOM   7523  C  C     . LEU B 1 466 ? 125.234 111.709 105.121 1.00 34.20  ? 458 LEU B C     1 
ATOM   7524  O  O     . LEU B 1 466 ? 125.137 112.410 104.112 1.00 36.34  ? 458 LEU B O     1 
ATOM   7525  C  CB    . LEU B 1 466 ? 126.835 109.833 104.756 1.00 31.90  ? 458 LEU B CB    1 
ATOM   7526  C  CG    . LEU B 1 466 ? 127.125 108.356 104.504 1.00 35.75  ? 458 LEU B CG    1 
ATOM   7527  C  CD1   . LEU B 1 466 ? 128.590 108.163 104.168 1.00 41.07  ? 458 LEU B CD1   1 
ATOM   7528  C  CD2   . LEU B 1 466 ? 126.731 107.527 105.710 1.00 30.48  ? 458 LEU B CD2   1 
ATOM   7529  N  N     . TYR B 1 467 ? 125.234 112.207 106.356 1.00 32.71  ? 459 TYR B N     1 
ATOM   7530  C  CA    . TYR B 1 467 ? 125.182 113.639 106.644 1.00 32.65  ? 459 TYR B CA    1 
ATOM   7531  C  C     . TYR B 1 467 ? 123.994 114.298 105.943 1.00 33.26  ? 459 TYR B C     1 
ATOM   7532  O  O     . TYR B 1 467 ? 124.142 115.150 105.066 1.00 37.09  ? 459 TYR B O     1 
ATOM   7533  C  CB    . TYR B 1 467 ? 126.495 114.318 106.255 1.00 35.56  ? 459 TYR B CB    1 
ATOM   7534  C  CG    . TYR B 1 467 ? 127.708 113.777 106.972 1.00 36.52  ? 459 TYR B CG    1 
ATOM   7535  C  CD1   . TYR B 1 467 ? 128.130 114.327 108.174 1.00 41.71  ? 459 TYR B CD1   1 
ATOM   7536  C  CD2   . TYR B 1 467 ? 128.436 112.722 106.445 1.00 36.16  ? 459 TYR B CD2   1 
ATOM   7537  C  CE1   . TYR B 1 467 ? 129.240 113.839 108.830 1.00 42.41  ? 459 TYR B CE1   1 
ATOM   7538  C  CE2   . TYR B 1 467 ? 129.547 112.227 107.094 1.00 39.61  ? 459 TYR B CE2   1 
ATOM   7539  C  CZ    . TYR B 1 467 ? 129.945 112.789 108.286 1.00 42.38  ? 459 TYR B CZ    1 
ATOM   7540  O  OH    . TYR B 1 467 ? 131.052 112.298 108.936 1.00 45.60  ? 459 TYR B OH    1 
ATOM   7541  N  N     . PHE B 1 468 ? 122.795 113.879 106.352 1.00 31.33  ? 460 PHE B N     1 
ATOM   7542  C  CA    . PHE B 1 468 ? 121.575 114.374 105.726 1.00 30.19  ? 460 PHE B CA    1 
ATOM   7543  C  C     . PHE B 1 468 ? 121.369 115.866 105.952 1.00 28.87  ? 460 PHE B C     1 
ATOM   7544  O  O     . PHE B 1 468 ? 120.643 116.500 105.180 1.00 30.03  ? 460 PHE B O     1 
ATOM   7545  C  CB    . PHE B 1 468 ? 120.371 113.592 106.248 1.00 32.01  ? 460 PHE B CB    1 
ATOM   7546  C  CG    . PHE B 1 468 ? 119.117 113.806 105.455 1.00 32.91  ? 460 PHE B CG    1 
ATOM   7547  C  CD1   . PHE B 1 468 ? 118.877 113.072 104.307 1.00 34.13  ? 460 PHE B CD1   1 
ATOM   7548  C  CD2   . PHE B 1 468 ? 118.172 114.729 105.863 1.00 32.70  ? 460 PHE B CD2   1 
ATOM   7549  C  CE1   . PHE B 1 468 ? 117.722 113.262 103.577 1.00 34.45  ? 460 PHE B CE1   1 
ATOM   7550  C  CE2   . PHE B 1 468 ? 117.016 114.922 105.136 1.00 36.23  ? 460 PHE B CE2   1 
ATOM   7551  C  CZ    . PHE B 1 468 ? 116.792 114.187 103.992 1.00 36.85  ? 460 PHE B CZ    1 
ATOM   7552  N  N     . LEU B 1 469 ? 121.984 116.438 106.980 1.00 33.64  ? 461 LEU B N     1 
ATOM   7553  C  CA    . LEU B 1 469 ? 121.910 117.865 107.254 1.00 33.49  ? 461 LEU B CA    1 
ATOM   7554  C  C     . LEU B 1 469 ? 123.315 118.449 107.294 1.00 36.23  ? 461 LEU B C     1 
ATOM   7555  O  O     . LEU B 1 469 ? 124.314 117.726 107.296 1.00 39.38  ? 461 LEU B O     1 
ATOM   7556  C  CB    . LEU B 1 469 ? 121.181 118.143 108.573 1.00 27.21  ? 461 LEU B CB    1 
ATOM   7557  C  CG    . LEU B 1 469 ? 119.797 117.517 108.742 1.00 27.06  ? 461 LEU B CG    1 
ATOM   7558  C  CD1   . LEU B 1 469 ? 119.166 117.972 110.042 1.00 34.71  ? 461 LEU B CD1   1 
ATOM   7559  C  CD2   . LEU B 1 469 ? 118.904 117.861 107.571 1.00 30.26  ? 461 LEU B CD2   1 
ATOM   7560  N  N     . HIS B 1 470 ? 123.383 119.778 107.326 1.00 38.25  ? 462 HIS B N     1 
ATOM   7561  C  CA    . HIS B 1 470 ? 124.670 120.459 107.341 1.00 44.26  ? 462 HIS B CA    1 
ATOM   7562  C  C     . HIS B 1 470 ? 125.470 120.065 108.576 1.00 43.74  ? 462 HIS B C     1 
ATOM   7563  O  O     . HIS B 1 470 ? 124.939 119.999 109.687 1.00 47.06  ? 462 HIS B O     1 
ATOM   7564  C  CB    . HIS B 1 470 ? 124.471 121.972 107.302 1.00 49.52  ? 462 HIS B CB    1 
ATOM   7565  C  CG    . HIS B 1 470 ? 125.750 122.748 107.277 1.00 54.52  ? 462 HIS B CG    1 
ATOM   7566  N  ND1   . HIS B 1 470 ? 126.718 122.554 106.316 1.00 53.04  ? 462 HIS B ND1   1 
ATOM   7567  C  CD2   . HIS B 1 470 ? 126.221 123.719 108.095 1.00 59.31  ? 462 HIS B CD2   1 
ATOM   7568  C  CE1   . HIS B 1 470 ? 127.730 123.372 106.542 1.00 55.18  ? 462 HIS B CE1   1 
ATOM   7569  N  NE2   . HIS B 1 470 ? 127.453 124.089 107.616 1.00 62.14  ? 462 HIS B NE2   1 
ATOM   7570  N  N     . TYR B 1 471 ? 126.759 119.804 108.373 1.00 45.10  ? 463 TYR B N     1 
ATOM   7571  C  CA    . TYR B 1 471 ? 127.633 119.291 109.416 1.00 49.38  ? 463 TYR B CA    1 
ATOM   7572  C  C     . TYR B 1 471 ? 128.930 120.084 109.440 1.00 52.99  ? 463 TYR B C     1 
ATOM   7573  O  O     . TYR B 1 471 ? 129.519 120.360 108.391 1.00 51.06  ? 463 TYR B O     1 
ATOM   7574  C  CB    . TYR B 1 471 ? 127.930 117.800 109.191 1.00 45.50  ? 463 TYR B CB    1 
ATOM   7575  C  CG    . TYR B 1 471 ? 128.834 117.170 110.227 1.00 45.54  ? 463 TYR B CG    1 
ATOM   7576  C  CD1   . TYR B 1 471 ? 130.214 117.195 110.081 1.00 48.63  ? 463 TYR B CD1   1 
ATOM   7577  C  CD2   . TYR B 1 471 ? 128.308 116.535 111.340 1.00 43.97  ? 463 TYR B CD2   1 
ATOM   7578  C  CE1   . TYR B 1 471 ? 131.042 116.618 111.020 1.00 49.25  ? 463 TYR B CE1   1 
ATOM   7579  C  CE2   . TYR B 1 471 ? 129.129 115.954 112.284 1.00 51.18  ? 463 TYR B CE2   1 
ATOM   7580  C  CZ    . TYR B 1 471 ? 130.495 115.999 112.118 1.00 53.09  ? 463 TYR B CZ    1 
ATOM   7581  O  OH    . TYR B 1 471 ? 131.318 115.421 113.056 1.00 56.61  ? 463 TYR B OH    1 
ATOM   7582  N  N     . GLU B 1 472 ? 129.370 120.446 110.642 1.00 56.24  ? 464 GLU B N     1 
ATOM   7583  C  CA    . GLU B 1 472 ? 130.660 121.088 110.844 1.00 56.68  ? 464 GLU B CA    1 
ATOM   7584  C  C     . GLU B 1 472 ? 131.331 120.473 112.062 1.00 60.03  ? 464 GLU B C     1 
ATOM   7585  O  O     . GLU B 1 472 ? 130.662 120.034 113.001 1.00 59.10  ? 464 GLU B O     1 
ATOM   7586  C  CB    . GLU B 1 472 ? 130.529 122.605 111.031 1.00 61.57  ? 464 GLU B CB    1 
ATOM   7587  C  CG    . GLU B 1 472 ? 130.055 123.349 109.795 1.00 68.13  ? 464 GLU B CG    1 
ATOM   7588  C  CD    . GLU B 1 472 ? 130.132 124.853 109.957 1.00 74.93  ? 464 GLU B CD    1 
ATOM   7589  O  OE1   . GLU B 1 472 ? 130.774 125.316 110.922 1.00 79.99  ? 464 GLU B OE1   1 
ATOM   7590  O  OE2   . GLU B 1 472 ? 129.549 125.573 109.119 1.00 76.59  ? 464 GLU B OE2   1 
ATOM   7591  N  N     . TYR B 1 473 ? 132.660 120.447 112.040 1.00 65.93  ? 465 TYR B N     1 
ATOM   7592  C  CA    . TYR B 1 473 ? 133.421 119.866 113.136 1.00 69.28  ? 465 TYR B CA    1 
ATOM   7593  C  C     . TYR B 1 473 ? 134.844 120.399 113.095 1.00 76.22  ? 465 TYR B C     1 
ATOM   7594  O  O     . TYR B 1 473 ? 135.389 120.671 112.022 1.00 76.99  ? 465 TYR B O     1 
ATOM   7595  C  CB    . TYR B 1 473 ? 133.422 118.334 113.068 1.00 65.91  ? 465 TYR B CB    1 
ATOM   7596  C  CG    . TYR B 1 473 ? 134.370 117.679 114.046 1.00 71.10  ? 465 TYR B CG    1 
ATOM   7597  C  CD1   . TYR B 1 473 ? 134.026 117.526 115.381 1.00 72.72  ? 465 TYR B CD1   1 
ATOM   7598  C  CD2   . TYR B 1 473 ? 135.612 117.216 113.633 1.00 70.53  ? 465 TYR B CD2   1 
ATOM   7599  C  CE1   . TYR B 1 473 ? 134.892 116.931 116.279 1.00 73.34  ? 465 TYR B CE1   1 
ATOM   7600  C  CE2   . TYR B 1 473 ? 136.485 116.621 114.522 1.00 74.71  ? 465 TYR B CE2   1 
ATOM   7601  C  CZ    . TYR B 1 473 ? 136.120 116.480 115.843 1.00 75.07  ? 465 TYR B CZ    1 
ATOM   7602  O  OH    . TYR B 1 473 ? 136.987 115.886 116.730 1.00 69.09  ? 465 TYR B OH    1 
ATOM   7603  N  N     . GLU B 1 474 ? 135.436 120.543 114.278 1.00 79.70  ? 466 GLU B N     1 
ATOM   7604  C  CA    . GLU B 1 474 ? 136.824 120.933 114.418 1.00 84.34  ? 466 GLU B CA    1 
ATOM   7605  C  C     . GLU B 1 474 ? 137.568 119.876 115.222 1.00 83.67  ? 466 GLU B C     1 
ATOM   7606  O  O     . GLU B 1 474 ? 137.071 119.440 116.271 1.00 83.08  ? 466 GLU B O     1 
ATOM   7607  C  CB    . GLU B 1 474 ? 136.948 122.301 115.107 1.00 90.68  ? 466 GLU B CB    1 
ATOM   7608  C  CG    . GLU B 1 474 ? 136.315 123.442 114.328 1.00 92.91  ? 466 GLU B CG    1 
ATOM   7609  C  CD    . GLU B 1 474 ? 136.562 124.794 114.968 1.00 102.39 ? 466 GLU B CD    1 
ATOM   7610  O  OE1   . GLU B 1 474 ? 137.283 124.849 115.987 1.00 107.88 ? 466 GLU B OE1   1 
ATOM   7611  O  OE2   . GLU B 1 474 ? 136.036 125.803 114.452 1.00 98.67  ? 466 GLU B OE2   1 
ATOM   7612  N  N     . PRO B 1 475 ? 138.738 119.428 114.768 1.00 86.60  ? 467 PRO B N     1 
ATOM   7613  C  CA    . PRO B 1 475 ? 139.465 118.388 115.503 1.00 89.75  ? 467 PRO B CA    1 
ATOM   7614  C  C     . PRO B 1 475 ? 139.882 118.862 116.887 1.00 92.96  ? 467 PRO B C     1 
ATOM   7615  O  O     . PRO B 1 475 ? 140.187 120.037 117.102 1.00 94.92  ? 467 PRO B O     1 
ATOM   7616  C  CB    . PRO B 1 475 ? 140.686 118.111 114.617 1.00 89.18  ? 467 PRO B CB    1 
ATOM   7617  C  CG    . PRO B 1 475 ? 140.305 118.622 113.262 1.00 88.59  ? 467 PRO B CG    1 
ATOM   7618  C  CD    . PRO B 1 475 ? 139.417 119.799 113.516 1.00 86.43  ? 467 PRO B CD    1 
ATOM   7619  N  N     . ALA B 1 476 ? 139.888 117.926 117.832 1.00 91.45  ? 468 ALA B N     1 
ATOM   7620  C  CA    . ALA B 1 476 ? 140.319 118.235 119.187 1.00 90.71  ? 468 ALA B CA    1 
ATOM   7621  C  C     . ALA B 1 476 ? 141.832 118.398 119.241 1.00 95.49  ? 468 ALA B C     1 
ATOM   7622  O  O     . ALA B 1 476 ? 142.579 117.634 118.623 1.00 94.28  ? 468 ALA B O     1 
ATOM   7623  C  CB    . ALA B 1 476 ? 139.873 117.137 120.150 1.00 86.64  ? 468 ALA B CB    1 
ATOM   7624  N  N     . ALA B 1 477 ? 142.283 119.409 119.987 1.00 98.46  ? 469 ALA B N     1 
ATOM   7625  C  CA    . ALA B 1 477 ? 143.717 119.648 120.119 1.00 97.59  ? 469 ALA B CA    1 
ATOM   7626  C  C     . ALA B 1 477 ? 144.407 118.500 120.844 1.00 96.94  ? 469 ALA B C     1 
ATOM   7627  O  O     . ALA B 1 477 ? 145.519 118.105 120.476 1.00 95.46  ? 469 ALA B O     1 
ATOM   7628  C  CB    . ALA B 1 477 ? 143.964 120.970 120.845 1.00 97.74  ? 469 ALA B CB    1 
ATOM   7629  N  N     . ASP B 1 478 ? 143.764 117.954 121.876 1.00 97.47  ? 470 ASP B N     1 
ATOM   7630  C  CA    . ASP B 1 478 ? 144.353 116.878 122.663 1.00 94.43  ? 470 ASP B CA    1 
ATOM   7631  C  C     . ASP B 1 478 ? 144.132 115.500 122.055 1.00 90.49  ? 470 ASP B C     1 
ATOM   7632  O  O     . ASP B 1 478 ? 144.668 114.520 122.585 1.00 86.46  ? 470 ASP B O     1 
ATOM   7633  C  CB    . ASP B 1 478 ? 143.794 116.908 124.087 1.00 91.94  ? 470 ASP B CB    1 
ATOM   7634  C  CG    . ASP B 1 478 ? 142.280 116.941 124.117 1.00 93.02  ? 470 ASP B CG    1 
ATOM   7635  O  OD1   . ASP B 1 478 ? 141.662 117.009 123.034 1.00 92.63  ? 470 ASP B OD1   1 
ATOM   7636  O  OD2   . ASP B 1 478 ? 141.705 116.899 125.225 1.00 91.42  ? 470 ASP B OD2   1 
ATOM   7637  N  N     . SER B 1 479 ? 143.364 115.403 120.968 1.00 90.48  ? 471 SER B N     1 
ATOM   7638  C  CA    . SER B 1 479 ? 143.100 114.133 120.288 1.00 88.76  ? 471 SER B CA    1 
ATOM   7639  C  C     . SER B 1 479 ? 142.480 113.106 121.235 1.00 81.11  ? 471 SER B C     1 
ATOM   7640  O  O     . SER B 1 479 ? 142.818 111.921 121.205 1.00 75.43  ? 471 SER B O     1 
ATOM   7641  C  CB    . SER B 1 479 ? 144.372 113.577 119.643 1.00 97.62  ? 471 SER B CB    1 
ATOM   7642  O  OG    . SER B 1 479 ? 144.911 114.494 118.707 1.00 102.91 ? 471 SER B OG    1 
ATOM   7643  N  N     . THR B 1 480 ? 141.563 113.568 122.090 1.00 81.65  ? 472 THR B N     1 
ATOM   7644  C  CA    . THR B 1 480 ? 140.851 112.692 123.014 1.00 78.86  ? 472 THR B CA    1 
ATOM   7645  C  C     . THR B 1 480 ? 139.342 112.899 122.941 1.00 73.68  ? 472 THR B C     1 
ATOM   7646  O  O     . THR B 1 480 ? 138.631 112.569 123.895 1.00 74.87  ? 472 THR B O     1 
ATOM   7647  C  CB    . THR B 1 480 ? 141.334 112.902 124.452 1.00 81.01  ? 472 THR B CB    1 
ATOM   7648  O  OG1   . THR B 1 480 ? 141.068 114.250 124.857 1.00 85.03  ? 472 THR B OG1   1 
ATOM   7649  C  CG2   . THR B 1 480 ? 142.826 112.629 124.565 1.00 83.28  ? 472 THR B CG2   1 
ATOM   7650  N  N     . ASP B 1 481 ? 138.842 113.438 121.834 1.00 69.49  ? 473 ASP B N     1 
ATOM   7651  C  CA    . ASP B 1 481 ? 137.428 113.761 121.725 1.00 63.76  ? 473 ASP B CA    1 
ATOM   7652  C  C     . ASP B 1 481 ? 136.585 112.494 121.627 1.00 60.07  ? 473 ASP B C     1 
ATOM   7653  O  O     . ASP B 1 481 ? 137.022 111.465 121.106 1.00 60.93  ? 473 ASP B O     1 
ATOM   7654  C  CB    . ASP B 1 481 ? 137.184 114.654 120.509 1.00 62.83  ? 473 ASP B CB    1 
ATOM   7655  C  CG    . ASP B 1 481 ? 135.878 115.416 120.596 1.00 67.79  ? 473 ASP B CG    1 
ATOM   7656  O  OD1   . ASP B 1 481 ? 134.885 114.855 121.105 1.00 68.84  ? 473 ASP B OD1   1 
ATOM   7657  O  OD2   . ASP B 1 481 ? 135.844 116.584 120.156 1.00 74.80  ? 473 ASP B OD2   1 
ATOM   7658  N  N     . VAL B 1 482 ? 135.360 112.580 122.142 1.00 59.43  ? 474 VAL B N     1 
ATOM   7659  C  CA    . VAL B 1 482 ? 134.423 111.464 122.171 1.00 54.34  ? 474 VAL B CA    1 
ATOM   7660  C  C     . VAL B 1 482 ? 133.133 111.894 121.490 1.00 53.32  ? 474 VAL B C     1 
ATOM   7661  O  O     . VAL B 1 482 ? 132.633 112.999 121.728 1.00 54.06  ? 474 VAL B O     1 
ATOM   7662  C  CB    . VAL B 1 482 ? 134.143 110.991 123.612 1.00 52.53  ? 474 VAL B CB    1 
ATOM   7663  C  CG1   . VAL B 1 482 ? 133.225 109.779 123.604 1.00 49.58  ? 474 VAL B CG1   1 
ATOM   7664  C  CG2   . VAL B 1 482 ? 135.441 110.675 124.332 1.00 59.52  ? 474 VAL B CG2   1 
ATOM   7665  N  N     . THR B 1 483 ? 132.598 111.022 120.641 1.00 48.59  ? 475 THR B N     1 
ATOM   7666  C  CA    . THR B 1 483 ? 131.356 111.273 119.925 1.00 45.33  ? 475 THR B CA    1 
ATOM   7667  C  C     . THR B 1 483 ? 130.266 110.354 120.457 1.00 41.66  ? 475 THR B C     1 
ATOM   7668  O  O     . THR B 1 483 ? 130.451 109.135 120.515 1.00 40.43  ? 475 THR B O     1 
ATOM   7669  C  CB    . THR B 1 483 ? 131.530 111.056 118.420 1.00 45.23  ? 475 THR B CB    1 
ATOM   7670  O  OG1   . THR B 1 483 ? 132.287 112.136 117.863 1.00 48.70  ? 475 THR B OG1   1 
ATOM   7671  C  CG2   . THR B 1 483 ? 130.180 110.981 117.725 1.00 39.96  ? 475 THR B CG2   1 
ATOM   7672  N  N     . LEU B 1 484 ? 129.136 110.941 120.840 1.00 38.85  ? 476 LEU B N     1 
ATOM   7673  C  CA    . LEU B 1 484 ? 127.982 110.153 121.247 1.00 34.14  ? 476 LEU B CA    1 
ATOM   7674  C  C     . LEU B 1 484 ? 127.401 109.457 120.024 1.00 35.91  ? 476 LEU B C     1 
ATOM   7675  O  O     . LEU B 1 484 ? 126.980 110.115 119.068 1.00 37.33  ? 476 LEU B O     1 
ATOM   7676  C  CB    . LEU B 1 484 ? 126.940 111.048 121.915 1.00 33.48  ? 476 LEU B CB    1 
ATOM   7677  C  CG    . LEU B 1 484 ? 125.899 110.408 122.838 1.00 35.62  ? 476 LEU B CG    1 
ATOM   7678  C  CD1   . LEU B 1 484 ? 125.334 111.455 123.780 1.00 39.84  ? 476 LEU B CD1   1 
ATOM   7679  C  CD2   . LEU B 1 484 ? 124.776 109.744 122.058 1.00 30.31  ? 476 LEU B CD2   1 
ATOM   7680  N  N     . VAL B 1 485 ? 127.381 108.130 120.049 1.00 34.97  ? 477 VAL B N     1 
ATOM   7681  C  CA    . VAL B 1 485 ? 126.914 107.323 118.929 1.00 29.76  ? 477 VAL B CA    1 
ATOM   7682  C  C     . VAL B 1 485 ? 125.600 106.675 119.333 1.00 33.47  ? 477 VAL B C     1 
ATOM   7683  O  O     . VAL B 1 485 ? 125.534 105.964 120.343 1.00 42.44  ? 477 VAL B O     1 
ATOM   7684  C  CB    . VAL B 1 485 ? 127.950 106.266 118.522 1.00 35.39  ? 477 VAL B CB    1 
ATOM   7685  C  CG1   . VAL B 1 485 ? 127.340 105.272 117.552 1.00 38.50  ? 477 VAL B CG1   1 
ATOM   7686  C  CG2   . VAL B 1 485 ? 129.169 106.933 117.912 1.00 34.86  ? 477 VAL B CG2   1 
ATOM   7687  N  N     . ALA B 1 486 ? 124.556 106.917 118.546 1.00 28.41  ? 478 ALA B N     1 
ATOM   7688  C  CA    . ALA B 1 486 ? 123.248 106.351 118.825 1.00 31.89  ? 478 ALA B CA    1 
ATOM   7689  C  C     . ALA B 1 486 ? 122.484 106.203 117.521 1.00 32.67  ? 478 ALA B C     1 
ATOM   7690  O  O     . ALA B 1 486 ? 122.815 106.824 116.510 1.00 34.77  ? 478 ALA B O     1 
ATOM   7691  C  CB    . ALA B 1 486 ? 122.460 107.214 119.816 1.00 31.86  ? 478 ALA B CB    1 
ATOM   7692  N  N     . GLN B 1 487 ? 121.458 105.360 117.554 1.00 34.94  ? 479 GLN B N     1 
ATOM   7693  C  CA    . GLN B 1 487 ? 120.571 105.179 116.417 1.00 38.65  ? 479 GLN B CA    1 
ATOM   7694  C  C     . GLN B 1 487 ? 119.133 105.209 116.908 1.00 40.51  ? 479 GLN B C     1 
ATOM   7695  O  O     . GLN B 1 487 ? 118.839 104.809 118.037 1.00 41.62  ? 479 GLN B O     1 
ATOM   7696  C  CB    . GLN B 1 487 ? 120.867 103.870 115.673 1.00 38.87  ? 479 GLN B CB    1 
ATOM   7697  C  CG    . GLN B 1 487 ? 120.903 102.637 116.555 1.00 40.73  ? 479 GLN B CG    1 
ATOM   7698  C  CD    . GLN B 1 487 ? 119.536 102.022 116.760 1.00 42.80  ? 479 GLN B CD    1 
ATOM   7699  O  OE1   . GLN B 1 487 ? 118.580 102.361 116.066 1.00 43.11  ? 479 GLN B OE1   1 
ATOM   7700  N  NE2   . GLN B 1 487 ? 119.436 101.111 117.719 1.00 42.54  ? 479 GLN B NE2   1 
ATOM   7701  N  N     . LEU B 1 488 ? 118.238 105.686 116.048 1.00 40.64  ? 480 LEU B N     1 
ATOM   7702  C  CA    . LEU B 1 488 ? 116.846 105.851 116.434 1.00 40.73  ? 480 LEU B CA    1 
ATOM   7703  C  C     . LEU B 1 488 ? 115.961 105.716 115.207 1.00 43.70  ? 480 LEU B C     1 
ATOM   7704  O  O     . LEU B 1 488 ? 116.416 105.849 114.070 1.00 40.98  ? 480 LEU B O     1 
ATOM   7705  C  CB    . LEU B 1 488 ? 116.600 107.207 117.104 1.00 39.56  ? 480 LEU B CB    1 
ATOM   7706  C  CG    . LEU B 1 488 ? 116.649 108.440 116.200 1.00 41.91  ? 480 LEU B CG    1 
ATOM   7707  C  CD1   . LEU B 1 488 ? 115.862 109.579 116.820 1.00 40.85  ? 480 LEU B CD1   1 
ATOM   7708  C  CD2   . LEU B 1 488 ? 118.082 108.874 115.935 1.00 39.28  ? 480 LEU B CD2   1 
ATOM   7709  N  N     . SER B 1 489 ? 114.687 105.445 115.460 1.00 48.81  ? 481 SER B N     1 
ATOM   7710  C  CA    . SER B 1 489 ? 113.649 105.516 114.450 1.00 45.58  ? 481 SER B CA    1 
ATOM   7711  C  C     . SER B 1 489 ? 112.879 106.823 114.632 1.00 49.13  ? 481 SER B C     1 
ATOM   7712  O  O     . SER B 1 489 ? 113.247 107.679 115.444 1.00 53.39  ? 481 SER B O     1 
ATOM   7713  C  CB    . SER B 1 489 ? 112.741 104.290 114.530 1.00 48.72  ? 481 SER B CB    1 
ATOM   7714  O  OG    . SER B 1 489 ? 112.157 104.173 115.814 1.00 59.64  ? 481 SER B OG    1 
ATOM   7715  N  N     . MET B 1 490 ? 111.802 106.991 113.863 1.00 53.17  ? 482 MET B N     1 
ATOM   7716  C  CA    . MET B 1 490 ? 111.044 108.238 113.906 1.00 53.07  ? 482 MET B CA    1 
ATOM   7717  C  C     . MET B 1 490 ? 110.422 108.461 115.280 1.00 55.28  ? 482 MET B C     1 
ATOM   7718  O  O     . MET B 1 490 ? 110.506 109.559 115.844 1.00 55.03  ? 482 MET B O     1 
ATOM   7719  C  CB    . MET B 1 490 ? 109.965 108.226 112.824 1.00 50.33  ? 482 MET B CB    1 
ATOM   7720  C  CG    . MET B 1 490 ? 109.294 109.566 112.600 1.00 53.18  ? 482 MET B CG    1 
ATOM   7721  S  SD    . MET B 1 490 ? 110.353 110.738 111.737 1.00 60.36  ? 482 MET B SD    1 
ATOM   7722  C  CE    . MET B 1 490 ? 109.222 112.109 111.534 1.00 53.99  ? 482 MET B CE    1 
ATOM   7723  N  N     . ASP B 1 491 ? 109.821 107.417 115.849 1.00 53.70  ? 483 ASP B N     1 
ATOM   7724  C  CA    . ASP B 1 491 ? 109.086 107.533 117.103 1.00 53.13  ? 483 ASP B CA    1 
ATOM   7725  C  C     . ASP B 1 491 ? 109.972 107.869 118.297 1.00 55.62  ? 483 ASP B C     1 
ATOM   7726  O  O     . ASP B 1 491 ? 109.469 107.891 119.425 1.00 55.73  ? 483 ASP B O     1 
ATOM   7727  C  CB    . ASP B 1 491 ? 108.317 106.238 117.374 1.00 57.14  ? 483 ASP B CB    1 
ATOM   7728  C  CG    . ASP B 1 491 ? 109.201 105.009 117.311 1.00 62.72  ? 483 ASP B CG    1 
ATOM   7729  O  OD1   . ASP B 1 491 ? 110.424 105.160 117.116 1.00 63.20  ? 483 ASP B OD1   1 
ATOM   7730  O  OD2   . ASP B 1 491 ? 108.669 103.888 117.455 1.00 69.96  ? 483 ASP B OD2   1 
ATOM   7731  N  N     . ARG B 1 492 ? 111.264 108.119 118.090 1.00 53.91  ? 484 ARG B N     1 
ATOM   7732  C  CA    . ARG B 1 492 ? 112.165 108.531 119.157 1.00 52.93  ? 484 ARG B CA    1 
ATOM   7733  C  C     . ARG B 1 492 ? 112.644 109.968 118.997 1.00 51.76  ? 484 ARG B C     1 
ATOM   7734  O  O     . ARG B 1 492 ? 113.500 110.410 119.771 1.00 50.06  ? 484 ARG B O     1 
ATOM   7735  C  CB    . ARG B 1 492 ? 113.371 107.593 119.221 1.00 52.88  ? 484 ARG B CB    1 
ATOM   7736  C  CG    . ARG B 1 492 ? 113.028 106.126 119.389 1.00 51.85  ? 484 ARG B CG    1 
ATOM   7737  C  CD    . ARG B 1 492 ? 112.316 105.866 120.700 1.00 51.35  ? 484 ARG B CD    1 
ATOM   7738  N  NE    . ARG B 1 492 ? 112.472 104.482 121.131 1.00 48.72  ? 484 ARG B NE    1 
ATOM   7739  C  CZ    . ARG B 1 492 ? 111.750 103.469 120.676 1.00 53.44  ? 484 ARG B CZ    1 
ATOM   7740  N  NH1   . ARG B 1 492 ? 110.807 103.645 119.765 1.00 56.54  ? 484 ARG B NH1   1 
ATOM   7741  N  NH2   . ARG B 1 492 ? 111.981 102.246 121.144 1.00 53.54  ? 484 ARG B NH2   1 
ATOM   7742  N  N     . LEU B 1 493 ? 112.109 110.708 118.019 1.00 49.40  ? 485 LEU B N     1 
ATOM   7743  C  CA    . LEU B 1 493 ? 112.625 112.045 117.730 1.00 48.65  ? 485 LEU B CA    1 
ATOM   7744  C  C     . LEU B 1 493 ? 112.581 112.955 118.950 1.00 52.54  ? 485 LEU B C     1 
ATOM   7745  O  O     . LEU B 1 493 ? 113.462 113.809 119.117 1.00 51.49  ? 485 LEU B O     1 
ATOM   7746  C  CB    . LEU B 1 493 ? 111.841 112.680 116.583 1.00 47.63  ? 485 LEU B CB    1 
ATOM   7747  C  CG    . LEU B 1 493 ? 112.168 112.217 115.165 1.00 52.29  ? 485 LEU B CG    1 
ATOM   7748  C  CD1   . LEU B 1 493 ? 111.503 113.134 114.157 1.00 50.89  ? 485 LEU B CD1   1 
ATOM   7749  C  CD2   . LEU B 1 493 ? 113.669 112.179 114.944 1.00 52.03  ? 485 LEU B CD2   1 
ATOM   7750  N  N     . GLN B 1 494 ? 111.585 112.778 119.820 1.00 53.56  ? 486 GLN B N     1 
ATOM   7751  C  CA    . GLN B 1 494 ? 111.452 113.635 120.991 1.00 52.77  ? 486 GLN B CA    1 
ATOM   7752  C  C     . GLN B 1 494 ? 112.672 113.575 121.896 1.00 54.78  ? 486 GLN B C     1 
ATOM   7753  O  O     . GLN B 1 494 ? 112.897 114.506 122.677 1.00 56.82  ? 486 GLN B O     1 
ATOM   7754  C  CB    . GLN B 1 494 ? 110.203 113.255 121.788 1.00 56.79  ? 486 GLN B CB    1 
ATOM   7755  C  CG    . GLN B 1 494 ? 110.169 111.810 122.259 1.00 59.17  ? 486 GLN B CG    1 
ATOM   7756  C  CD    . GLN B 1 494 ? 109.635 110.862 121.204 1.00 61.06  ? 486 GLN B CD    1 
ATOM   7757  O  OE1   . GLN B 1 494 ? 109.270 111.281 120.106 1.00 56.85  ? 486 GLN B OE1   1 
ATOM   7758  N  NE2   . GLN B 1 494 ? 109.584 109.577 121.534 1.00 63.39  ? 486 GLN B NE2   1 
ATOM   7759  N  N     . MET B 1 495 ? 113.466 112.507 121.809 1.00 52.83  ? 487 MET B N     1 
ATOM   7760  C  CA    . MET B 1 495 ? 114.660 112.420 122.640 1.00 49.82  ? 487 MET B CA    1 
ATOM   7761  C  C     . MET B 1 495 ? 115.758 113.358 122.156 1.00 48.32  ? 487 MET B C     1 
ATOM   7762  O  O     . MET B 1 495 ? 116.527 113.876 122.975 1.00 46.95  ? 487 MET B O     1 
ATOM   7763  C  CB    . MET B 1 495 ? 115.172 110.982 122.674 1.00 49.07  ? 487 MET B CB    1 
ATOM   7764  C  CG    . MET B 1 495 ? 114.197 109.991 123.287 1.00 54.21  ? 487 MET B CG    1 
ATOM   7765  S  SD    . MET B 1 495 ? 113.733 110.425 124.974 1.00 68.26  ? 487 MET B SD    1 
ATOM   7766  C  CE    . MET B 1 495 ? 115.339 110.519 125.760 1.00 49.74  ? 487 MET B CE    1 
ATOM   7767  N  N     . LEU B 1 496 ? 115.822 113.615 120.844 1.00 46.88  ? 488 LEU B N     1 
ATOM   7768  C  CA    . LEU B 1 496 ? 116.999 114.252 120.258 1.00 44.96  ? 488 LEU B CA    1 
ATOM   7769  C  C     . LEU B 1 496 ? 117.332 115.568 120.946 1.00 46.20  ? 488 LEU B C     1 
ATOM   7770  O  O     . LEU B 1 496 ? 118.451 115.758 121.438 1.00 47.94  ? 488 LEU B O     1 
ATOM   7771  C  CB    . LEU B 1 496 ? 116.782 114.482 118.762 1.00 42.65  ? 488 LEU B CB    1 
ATOM   7772  C  CG    . LEU B 1 496 ? 116.714 113.247 117.867 1.00 42.34  ? 488 LEU B CG    1 
ATOM   7773  C  CD1   . LEU B 1 496 ? 116.676 113.661 116.408 1.00 42.66  ? 488 LEU B CD1   1 
ATOM   7774  C  CD2   . LEU B 1 496 ? 117.893 112.335 118.135 1.00 40.86  ? 488 LEU B CD2   1 
ATOM   7775  N  N     . GLU B 1 497 ? 116.351 116.471 121.033 1.00 47.75  ? 489 GLU B N     1 
ATOM   7776  C  CA    . GLU B 1 497 ? 116.597 117.762 121.666 1.00 49.93  ? 489 GLU B CA    1 
ATOM   7777  C  C     . GLU B 1 497 ? 117.089 117.580 123.093 1.00 48.73  ? 489 GLU B C     1 
ATOM   7778  O  O     . GLU B 1 497 ? 118.074 118.207 123.501 1.00 50.10  ? 489 GLU B O     1 
ATOM   7779  C  CB    . GLU B 1 497 ? 115.329 118.615 121.641 1.00 54.48  ? 489 GLU B CB    1 
ATOM   7780  C  CG    . GLU B 1 497 ? 114.900 119.050 120.252 1.00 56.99  ? 489 GLU B CG    1 
ATOM   7781  C  CD    . GLU B 1 497 ? 113.705 119.984 120.279 1.00 60.72  ? 489 GLU B CD    1 
ATOM   7782  O  OE1   . GLU B 1 497 ? 113.169 120.236 121.378 1.00 59.44  ? 489 GLU B OE1   1 
ATOM   7783  O  OE2   . GLU B 1 497 ? 113.304 120.467 119.200 1.00 62.84  ? 489 GLU B OE2   1 
ATOM   7784  N  N     . ALA B 1 498 ? 116.444 116.688 123.849 1.00 47.17  ? 490 ALA B N     1 
ATOM   7785  C  CA    . ALA B 1 498 ? 116.888 116.419 125.210 1.00 46.33  ? 490 ALA B CA    1 
ATOM   7786  C  C     . ALA B 1 498 ? 118.350 115.999 125.223 1.00 48.31  ? 490 ALA B C     1 
ATOM   7787  O  O     . ALA B 1 498 ? 119.149 116.510 126.017 1.00 49.16  ? 490 ALA B O     1 
ATOM   7788  C  CB    . ALA B 1 498 ? 116.007 115.345 125.845 1.00 47.60  ? 490 ALA B CB    1 
ATOM   7789  N  N     . ILE B 1 499 ? 118.727 115.100 124.311 1.00 46.76  ? 491 ILE B N     1 
ATOM   7790  C  CA    . ILE B 1 499 ? 120.120 114.677 124.228 1.00 46.10  ? 491 ILE B CA    1 
ATOM   7791  C  C     . ILE B 1 499 ? 121.009 115.867 123.905 1.00 48.80  ? 491 ILE B C     1 
ATOM   7792  O  O     . ILE B 1 499 ? 122.075 116.048 124.508 1.00 50.68  ? 491 ILE B O     1 
ATOM   7793  C  CB    . ILE B 1 499 ? 120.276 113.548 123.194 1.00 46.88  ? 491 ILE B CB    1 
ATOM   7794  C  CG1   . ILE B 1 499 ? 119.477 112.321 123.633 1.00 48.55  ? 491 ILE B CG1   1 
ATOM   7795  C  CG2   . ILE B 1 499 ? 121.740 113.195 123.007 1.00 44.87  ? 491 ILE B CG2   1 
ATOM   7796  C  CD1   . ILE B 1 499 ? 119.655 111.123 122.736 1.00 43.55  ? 491 ILE B CD1   1 
ATOM   7797  N  N     . CYS B 1 500 ? 120.570 116.719 122.976 1.00 47.86  ? 492 CYS B N     1 
ATOM   7798  C  CA    . CYS B 1 500 ? 121.356 117.896 122.636 1.00 46.97  ? 492 CYS B CA    1 
ATOM   7799  C  C     . CYS B 1 500 ? 121.471 118.858 123.808 1.00 50.87  ? 492 CYS B C     1 
ATOM   7800  O  O     . CYS B 1 500 ? 122.390 119.684 123.830 1.00 52.16  ? 492 CYS B O     1 
ATOM   7801  C  CB    . CYS B 1 500 ? 120.747 118.605 121.426 1.00 52.19  ? 492 CYS B CB    1 
ATOM   7802  S  SG    . CYS B 1 500 ? 120.719 117.604 119.920 1.00 56.98  ? 492 CYS B SG    1 
ATOM   7803  N  N     . LYS B 1 501 ? 120.562 118.772 124.782 1.00 51.93  ? 493 LYS B N     1 
ATOM   7804  C  CA    . LYS B 1 501 ? 120.672 119.610 125.967 1.00 50.86  ? 493 LYS B CA    1 
ATOM   7805  C  C     . LYS B 1 501 ? 121.616 119.027 127.007 1.00 52.59  ? 493 LYS B C     1 
ATOM   7806  O  O     . LYS B 1 501 ? 122.023 119.747 127.925 1.00 56.09  ? 493 LYS B O     1 
ATOM   7807  C  CB    . LYS B 1 501 ? 119.291 119.831 126.586 1.00 52.52  ? 493 LYS B CB    1 
ATOM   7808  C  CG    . LYS B 1 501 ? 118.342 120.629 125.708 1.00 55.22  ? 493 LYS B CG    1 
ATOM   7809  C  CD    . LYS B 1 501 ? 117.016 120.870 126.406 1.00 55.23  ? 493 LYS B CD    1 
ATOM   7810  C  CE    . LYS B 1 501 ? 116.077 121.685 125.535 1.00 56.13  ? 493 LYS B CE    1 
ATOM   7811  N  NZ    . LYS B 1 501 ? 114.781 121.947 126.219 1.00 67.30  ? 493 LYS B NZ    1 
ATOM   7812  N  N     . HIS B 1 502 ? 121.978 117.752 126.884 1.00 50.14  ? 494 HIS B N     1 
ATOM   7813  C  CA    . HIS B 1 502 ? 122.875 117.106 127.834 1.00 50.22  ? 494 HIS B CA    1 
ATOM   7814  C  C     . HIS B 1 502 ? 124.290 116.941 127.302 1.00 54.32  ? 494 HIS B C     1 
ATOM   7815  O  O     . HIS B 1 502 ? 125.252 117.090 128.061 1.00 59.72  ? 494 HIS B O     1 
ATOM   7816  C  CB    . HIS B 1 502 ? 122.326 115.734 128.234 1.00 52.69  ? 494 HIS B CB    1 
ATOM   7817  C  CG    . HIS B 1 502 ? 121.141 115.795 129.147 1.00 57.80  ? 494 HIS B CG    1 
ATOM   7818  N  ND1   . HIS B 1 502 ? 121.179 116.419 130.376 1.00 59.25  ? 494 HIS B ND1   1 
ATOM   7819  C  CD2   . HIS B 1 502 ? 119.890 115.294 129.018 1.00 56.00  ? 494 HIS B CD2   1 
ATOM   7820  C  CE1   . HIS B 1 502 ? 119.999 116.307 130.960 1.00 58.05  ? 494 HIS B CE1   1 
ATOM   7821  N  NE2   . HIS B 1 502 ? 119.199 115.629 130.157 1.00 58.02  ? 494 HIS B NE2   1 
ATOM   7822  N  N     . TRP B 1 503 ? 124.442 116.638 126.016 1.00 49.53  ? 495 TRP B N     1 
ATOM   7823  C  CA    . TRP B 1 503 ? 125.738 116.353 125.412 1.00 45.43  ? 495 TRP B CA    1 
ATOM   7824  C  C     . TRP B 1 503 ? 126.122 117.520 124.511 1.00 49.58  ? 495 TRP B C     1 
ATOM   7825  O  O     . TRP B 1 503 ? 125.467 117.767 123.494 1.00 51.17  ? 495 TRP B O     1 
ATOM   7826  C  CB    . TRP B 1 503 ? 125.689 115.044 124.628 1.00 42.04  ? 495 TRP B CB    1 
ATOM   7827  C  CG    . TRP B 1 503 ? 127.020 114.591 124.126 1.00 44.34  ? 495 TRP B CG    1 
ATOM   7828  C  CD1   . TRP B 1 503 ? 127.607 114.927 122.944 1.00 44.51  ? 495 TRP B CD1   1 
ATOM   7829  C  CD2   . TRP B 1 503 ? 127.934 113.711 124.791 1.00 45.61  ? 495 TRP B CD2   1 
ATOM   7830  N  NE1   . TRP B 1 503 ? 128.830 114.315 122.831 1.00 42.95  ? 495 TRP B NE1   1 
ATOM   7831  C  CE2   . TRP B 1 503 ? 129.054 113.562 123.953 1.00 44.86  ? 495 TRP B CE2   1 
ATOM   7832  C  CE3   . TRP B 1 503 ? 127.913 113.037 126.015 1.00 45.35  ? 495 TRP B CE3   1 
ATOM   7833  C  CZ2   . TRP B 1 503 ? 130.144 112.767 124.298 1.00 44.73  ? 495 TRP B CZ2   1 
ATOM   7834  C  CZ3   . TRP B 1 503 ? 128.994 112.248 126.355 1.00 43.46  ? 495 TRP B CZ3   1 
ATOM   7835  C  CH2   . TRP B 1 503 ? 130.094 112.119 125.500 1.00 42.98  ? 495 TRP B CH2   1 
ATOM   7836  N  N     . GLU B 1 504 ? 127.181 118.234 124.884 1.00 50.41  ? 496 GLU B N     1 
ATOM   7837  C  CA    . GLU B 1 504 ? 127.662 119.367 124.106 1.00 48.00  ? 496 GLU B CA    1 
ATOM   7838  C  C     . GLU B 1 504 ? 128.686 118.969 123.052 1.00 47.55  ? 496 GLU B C     1 
ATOM   7839  O  O     . GLU B 1 504 ? 129.105 119.823 122.264 1.00 47.44  ? 496 GLU B O     1 
ATOM   7840  C  CB    . GLU B 1 504 ? 128.273 120.427 125.028 1.00 51.83  ? 496 GLU B CB    1 
ATOM   7841  C  CG    . GLU B 1 504 ? 127.552 120.602 126.352 1.00 59.00  ? 496 GLU B CG    1 
ATOM   7842  C  CD    . GLU B 1 504 ? 128.108 119.702 127.438 1.00 67.19  ? 496 GLU B CD    1 
ATOM   7843  O  OE1   . GLU B 1 504 ? 129.239 119.199 127.270 1.00 66.59  ? 496 GLU B OE1   1 
ATOM   7844  O  OE2   . GLU B 1 504 ? 127.416 119.496 128.457 1.00 67.74  ? 496 GLU B OE2   1 
ATOM   7845  N  N     . GLY B 1 505 ? 129.101 117.706 123.021 1.00 48.64  ? 497 GLY B N     1 
ATOM   7846  C  CA    . GLY B 1 505 ? 130.098 117.254 122.083 1.00 47.29  ? 497 GLY B CA    1 
ATOM   7847  C  C     . GLY B 1 505 ? 129.494 116.728 120.798 1.00 46.44  ? 497 GLY B C     1 
ATOM   7848  O  O     . GLY B 1 505 ? 128.275 116.741 120.605 1.00 47.85  ? 497 GLY B O     1 
ATOM   7849  N  N     . PRO B 1 506 ? 130.346 116.263 119.886 1.00 46.31  ? 498 PRO B N     1 
ATOM   7850  C  CA    . PRO B 1 506 ? 129.846 115.736 118.611 1.00 42.12  ? 498 PRO B CA    1 
ATOM   7851  C  C     . PRO B 1 506 ? 128.960 114.517 118.814 1.00 39.49  ? 498 PRO B C     1 
ATOM   7852  O  O     . PRO B 1 506 ? 129.196 113.690 119.696 1.00 43.85  ? 498 PRO B O     1 
ATOM   7853  C  CB    . PRO B 1 506 ? 131.127 115.384 117.847 1.00 45.07  ? 498 PRO B CB    1 
ATOM   7854  C  CG    . PRO B 1 506 ? 132.173 115.236 118.899 1.00 48.67  ? 498 PRO B CG    1 
ATOM   7855  C  CD    . PRO B 1 506 ? 131.814 116.214 119.969 1.00 48.14  ? 498 PRO B CD    1 
ATOM   7856  N  N     . ILE B 1 507 ? 127.927 114.416 117.981 1.00 34.83  ? 499 ILE B N     1 
ATOM   7857  C  CA    . ILE B 1 507 ? 126.962 113.326 118.035 1.00 31.10  ? 499 ILE B CA    1 
ATOM   7858  C  C     . ILE B 1 507 ? 126.842 112.726 116.644 1.00 32.58  ? 499 ILE B C     1 
ATOM   7859  O  O     . ILE B 1 507 ? 126.818 113.453 115.646 1.00 41.08  ? 499 ILE B O     1 
ATOM   7860  C  CB    . ILE B 1 507 ? 125.584 113.807 118.539 1.00 34.39  ? 499 ILE B CB    1 
ATOM   7861  C  CG1   . ILE B 1 507 ? 125.727 114.577 119.852 1.00 38.02  ? 499 ILE B CG1   1 
ATOM   7862  C  CG2   . ILE B 1 507 ? 124.638 112.633 118.719 1.00 30.73  ? 499 ILE B CG2   1 
ATOM   7863  C  CD1   . ILE B 1 507 ? 124.417 115.084 120.406 1.00 36.08  ? 499 ILE B CD1   1 
ATOM   7864  N  N     . SER B 1 508 ? 126.781 111.399 116.575 1.00 32.17  ? 500 SER B N     1 
ATOM   7865  C  CA    . SER B 1 508 ? 126.597 110.679 115.320 1.00 29.19  ? 500 SER B CA    1 
ATOM   7866  C  C     . SER B 1 508 ? 125.351 109.814 115.451 1.00 28.42  ? 500 SER B C     1 
ATOM   7867  O  O     . SER B 1 508 ? 125.320 108.882 116.260 1.00 35.45  ? 500 SER B O     1 
ATOM   7868  C  CB    . SER B 1 508 ? 127.823 109.833 114.985 1.00 33.59  ? 500 SER B CB    1 
ATOM   7869  O  OG    . SER B 1 508 ? 127.630 109.110 113.783 1.00 36.27  ? 500 SER B OG    1 
ATOM   7870  N  N     . LEU B 1 509 ? 124.332 110.119 114.656 1.00 26.99  ? 501 LEU B N     1 
ATOM   7871  C  CA    . LEU B 1 509 ? 123.047 109.444 114.738 1.00 28.93  ? 501 LEU B CA    1 
ATOM   7872  C  C     . LEU B 1 509 ? 122.725 108.766 113.416 1.00 29.67  ? 501 LEU B C     1 
ATOM   7873  O  O     . LEU B 1 509 ? 123.108 109.243 112.345 1.00 34.02  ? 501 LEU B O     1 
ATOM   7874  C  CB    . LEU B 1 509 ? 121.929 110.427 115.098 1.00 29.54  ? 501 LEU B CB    1 
ATOM   7875  C  CG    . LEU B 1 509 ? 122.117 111.218 116.392 1.00 29.40  ? 501 LEU B CG    1 
ATOM   7876  C  CD1   . LEU B 1 509 ? 121.113 112.347 116.463 1.00 36.16  ? 501 LEU B CD1   1 
ATOM   7877  C  CD2   . LEU B 1 509 ? 121.985 110.309 117.599 1.00 30.02  ? 501 LEU B CD2   1 
ATOM   7878  N  N     . ALA B 1 510 ? 122.018 107.643 113.501 1.00 30.99  ? 502 ALA B N     1 
ATOM   7879  C  CA    . ALA B 1 510 ? 121.552 106.908 112.331 1.00 30.66  ? 502 ALA B CA    1 
ATOM   7880  C  C     . ALA B 1 510 ? 120.039 106.777 112.428 1.00 35.81  ? 502 ALA B C     1 
ATOM   7881  O  O     . ALA B 1 510 ? 119.527 106.082 113.311 1.00 40.61  ? 502 ALA B O     1 
ATOM   7882  C  CB    . ALA B 1 510 ? 122.218 105.538 112.236 1.00 32.99  ? 502 ALA B CB    1 
ATOM   7883  N  N     . LEU B 1 511 ? 119.326 107.434 111.518 1.00 35.39  ? 503 LEU B N     1 
ATOM   7884  C  CA    . LEU B 1 511 ? 117.871 107.468 111.536 1.00 36.19  ? 503 LEU B CA    1 
ATOM   7885  C  C     . LEU B 1 511 ? 117.318 106.536 110.467 1.00 36.44  ? 503 LEU B C     1 
ATOM   7886  O  O     . LEU B 1 511 ? 117.697 106.631 109.296 1.00 35.28  ? 503 LEU B O     1 
ATOM   7887  C  CB    . LEU B 1 511 ? 117.356 108.891 111.315 1.00 38.34  ? 503 LEU B CB    1 
ATOM   7888  C  CG    . LEU B 1 511 ? 117.740 109.953 112.350 1.00 35.07  ? 503 LEU B CG    1 
ATOM   7889  C  CD1   . LEU B 1 511 ? 119.060 110.623 112.003 1.00 33.65  ? 503 LEU B CD1   1 
ATOM   7890  C  CD2   . LEU B 1 511 ? 116.636 110.985 112.488 1.00 38.77  ? 503 LEU B CD2   1 
ATOM   7891  N  N     . TYR B 1 512 ? 116.421 105.638 110.875 1.00 41.06  ? 504 TYR B N     1 
ATOM   7892  C  CA    . TYR B 1 512 ? 115.797 104.678 109.967 1.00 42.32  ? 504 TYR B CA    1 
ATOM   7893  C  C     . TYR B 1 512 ? 114.435 105.231 109.556 1.00 46.67  ? 504 TYR B C     1 
ATOM   7894  O  O     . TYR B 1 512 ? 113.393 104.879 110.106 1.00 50.10  ? 504 TYR B O     1 
ATOM   7895  C  CB    . TYR B 1 512 ? 115.685 103.312 110.632 1.00 42.63  ? 504 TYR B CB    1 
ATOM   7896  C  CG    . TYR B 1 512 ? 115.280 102.197 109.699 1.00 48.63  ? 504 TYR B CG    1 
ATOM   7897  C  CD1   . TYR B 1 512 ? 116.103 101.810 108.653 1.00 50.56  ? 504 TYR B CD1   1 
ATOM   7898  C  CD2   . TYR B 1 512 ? 114.083 101.518 109.875 1.00 50.38  ? 504 TYR B CD2   1 
ATOM   7899  C  CE1   . TYR B 1 512 ? 115.742 100.789 107.801 1.00 54.23  ? 504 TYR B CE1   1 
ATOM   7900  C  CE2   . TYR B 1 512 ? 113.713 100.493 109.028 1.00 51.68  ? 504 TYR B CE2   1 
ATOM   7901  C  CZ    . TYR B 1 512 ? 114.547 100.132 107.993 1.00 56.79  ? 504 TYR B CZ    1 
ATOM   7902  O  OH    . TYR B 1 512 ? 114.185 99.112  107.145 1.00 62.45  ? 504 TYR B OH    1 
ATOM   7903  N  N     . LEU B 1 513 ? 114.456 106.112 108.559 1.00 46.70  ? 505 LEU B N     1 
ATOM   7904  C  CA    . LEU B 1 513 ? 113.277 106.844 108.125 1.00 46.85  ? 505 LEU B CA    1 
ATOM   7905  C  C     . LEU B 1 513 ? 112.965 106.536 106.668 1.00 48.28  ? 505 LEU B C     1 
ATOM   7906  O  O     . LEU B 1 513 ? 113.862 106.242 105.874 1.00 53.89  ? 505 LEU B O     1 
ATOM   7907  C  CB    . LEU B 1 513 ? 113.480 108.352 108.285 1.00 43.66  ? 505 LEU B CB    1 
ATOM   7908  C  CG    . LEU B 1 513 ? 114.084 108.821 109.605 1.00 41.97  ? 505 LEU B CG    1 
ATOM   7909  C  CD1   . LEU B 1 513 ? 114.408 110.301 109.537 1.00 44.23  ? 505 LEU B CD1   1 
ATOM   7910  C  CD2   . LEU B 1 513 ? 113.138 108.526 110.753 1.00 45.34  ? 505 LEU B CD2   1 
ATOM   7911  N  N     . SER B 1 514 ? 111.683 106.610 106.322 1.00 50.09  ? 506 SER B N     1 
ATOM   7912  C  CA    . SER B 1 514 ? 111.277 106.568 104.927 1.00 53.66  ? 506 SER B CA    1 
ATOM   7913  C  C     . SER B 1 514 ? 111.407 107.963 104.320 1.00 54.64  ? 506 SER B C     1 
ATOM   7914  O  O     . SER B 1 514 ? 111.730 108.937 105.004 1.00 58.08  ? 506 SER B O     1 
ATOM   7915  C  CB    . SER B 1 514 ? 109.853 106.033 104.798 1.00 56.02  ? 506 SER B CB    1 
ATOM   7916  O  OG    . SER B 1 514 ? 108.918 106.932 105.363 1.00 61.83  ? 506 SER B OG    1 
ATOM   7917  N  N     . ASP B 1 515 ? 111.156 108.066 103.012 1.00 53.47  ? 507 ASP B N     1 
ATOM   7918  C  CA    . ASP B 1 515 ? 111.314 109.349 102.332 1.00 56.29  ? 507 ASP B CA    1 
ATOM   7919  C  C     . ASP B 1 515 ? 110.361 110.396 102.896 1.00 60.26  ? 507 ASP B C     1 
ATOM   7920  O  O     . ASP B 1 515 ? 110.763 111.538 103.155 1.00 60.78  ? 507 ASP B O     1 
ATOM   7921  C  CB    . ASP B 1 515 ? 111.096 109.174 100.830 1.00 63.47  ? 507 ASP B CB    1 
ATOM   7922  C  CG    . ASP B 1 515 ? 112.067 108.188 100.212 1.00 62.91  ? 507 ASP B CG    1 
ATOM   7923  O  OD1   . ASP B 1 515 ? 111.862 106.967 100.373 1.00 63.81  ? 507 ASP B OD1   1 
ATOM   7924  O  OD2   . ASP B 1 515 ? 113.039 108.635 99.569  1.00 57.05  ? 507 ASP B OD2   1 
ATOM   7925  N  N     . ALA B 1 516 ? 109.096 110.023 103.100 1.00 62.86  ? 508 ALA B N     1 
ATOM   7926  C  CA    . ALA B 1 516 ? 108.158 110.933 103.747 1.00 60.98  ? 508 ALA B CA    1 
ATOM   7927  C  C     . ALA B 1 516 ? 108.602 111.251 105.167 1.00 57.79  ? 508 ALA B C     1 
ATOM   7928  O  O     . ALA B 1 516 ? 108.581 112.414 105.588 1.00 60.37  ? 508 ALA B O     1 
ATOM   7929  C  CB    . ALA B 1 516 ? 106.755 110.331 103.741 1.00 63.95  ? 508 ALA B CB    1 
ATOM   7930  N  N     . GLU B 1 517 ? 109.021 110.230 105.918 1.00 54.55  ? 509 GLU B N     1 
ATOM   7931  C  CA    . GLU B 1 517 ? 109.545 110.468 107.257 1.00 52.43  ? 509 GLU B CA    1 
ATOM   7932  C  C     . GLU B 1 517 ? 110.841 111.263 107.216 1.00 50.39  ? 509 GLU B C     1 
ATOM   7933  O  O     . GLU B 1 517 ? 111.107 112.051 108.128 1.00 50.97  ? 509 GLU B O     1 
ATOM   7934  C  CB    . GLU B 1 517 ? 109.755 109.143 107.986 1.00 52.83  ? 509 GLU B CB    1 
ATOM   7935  C  CG    . GLU B 1 517 ? 108.477 108.363 108.227 1.00 55.82  ? 509 GLU B CG    1 
ATOM   7936  C  CD    . GLU B 1 517 ? 108.717 107.079 108.993 1.00 62.96  ? 509 GLU B CD    1 
ATOM   7937  O  OE1   . GLU B 1 517 ? 109.797 106.945 109.605 1.00 61.94  ? 509 GLU B OE1   1 
ATOM   7938  O  OE2   . GLU B 1 517 ? 107.828 106.203 108.981 1.00 67.04  ? 509 GLU B OE2   1 
ATOM   7939  N  N     . ALA B 1 518 ? 111.656 111.076 106.176 1.00 53.02  ? 510 ALA B N     1 
ATOM   7940  C  CA    . ALA B 1 518 ? 112.864 111.884 106.040 1.00 52.06  ? 510 ALA B CA    1 
ATOM   7941  C  C     . ALA B 1 518 ? 112.520 113.356 105.867 1.00 53.57  ? 510 ALA B C     1 
ATOM   7942  O  O     . ALA B 1 518 ? 113.153 114.225 106.477 1.00 56.95  ? 510 ALA B O     1 
ATOM   7943  C  CB    . ALA B 1 518 ? 113.704 111.388 104.864 1.00 48.22  ? 510 ALA B CB    1 
ATOM   7944  N  N     . GLN B 1 519 ? 111.512 113.658 105.046 1.00 53.57  ? 511 GLN B N     1 
ATOM   7945  C  CA    . GLN B 1 519 ? 111.110 115.051 104.871 1.00 53.58  ? 511 GLN B CA    1 
ATOM   7946  C  C     . GLN B 1 519 ? 110.478 115.611 106.141 1.00 55.41  ? 511 GLN B C     1 
ATOM   7947  O  O     . GLN B 1 519 ? 110.689 116.782 106.482 1.00 55.06  ? 511 GLN B O     1 
ATOM   7948  C  CB    . GLN B 1 519 ? 110.155 115.177 103.686 1.00 55.07  ? 511 GLN B CB    1 
ATOM   7949  C  CG    . GLN B 1 519 ? 110.775 114.773 102.361 1.00 65.58  ? 511 GLN B CG    1 
ATOM   7950  C  CD    . GLN B 1 519 ? 112.033 115.557 102.041 1.00 64.69  ? 511 GLN B CD    1 
ATOM   7951  O  OE1   . GLN B 1 519 ? 112.148 116.736 102.376 1.00 66.69  ? 511 GLN B OE1   1 
ATOM   7952  N  NE2   . GLN B 1 519 ? 112.988 114.903 101.390 1.00 52.29  ? 511 GLN B NE2   1 
ATOM   7953  N  N     . GLN B 1 520 ? 109.702 114.791 106.854 1.00 54.35  ? 512 GLN B N     1 
ATOM   7954  C  CA    . GLN B 1 520 ? 109.150 115.229 108.133 1.00 52.79  ? 512 GLN B CA    1 
ATOM   7955  C  C     . GLN B 1 520 ? 110.259 115.557 109.125 1.00 50.69  ? 512 GLN B C     1 
ATOM   7956  O  O     . GLN B 1 520 ? 110.193 116.571 109.829 1.00 50.43  ? 512 GLN B O     1 
ATOM   7957  C  CB    . GLN B 1 520 ? 108.228 114.156 108.707 1.00 56.10  ? 512 GLN B CB    1 
ATOM   7958  C  CG    . GLN B 1 520 ? 106.997 113.871 107.872 1.00 60.54  ? 512 GLN B CG    1 
ATOM   7959  C  CD    . GLN B 1 520 ? 106.230 112.665 108.371 1.00 64.88  ? 512 GLN B CD    1 
ATOM   7960  O  OE1   . GLN B 1 520 ? 106.464 112.181 109.479 1.00 65.58  ? 512 GLN B OE1   1 
ATOM   7961  N  NE2   . GLN B 1 520 ? 105.311 112.167 107.551 1.00 64.19  ? 512 GLN B NE2   1 
ATOM   7962  N  N     . PHE B 1 521 ? 111.287 114.709 109.192 1.00 49.93  ? 513 PHE B N     1 
ATOM   7963  C  CA    . PHE B 1 521 ? 112.416 114.977 110.074 1.00 48.40  ? 513 PHE B CA    1 
ATOM   7964  C  C     . PHE B 1 521 ? 113.170 116.227 109.646 1.00 46.53  ? 513 PHE B C     1 
ATOM   7965  O  O     . PHE B 1 521 ? 113.642 116.990 110.493 1.00 50.23  ? 513 PHE B O     1 
ATOM   7966  C  CB    . PHE B 1 521 ? 113.359 113.777 110.114 1.00 43.08  ? 513 PHE B CB    1 
ATOM   7967  C  CG    . PHE B 1 521 ? 114.724 114.107 110.643 1.00 41.65  ? 513 PHE B CG    1 
ATOM   7968  C  CD1   . PHE B 1 521 ? 114.931 114.271 112.000 1.00 43.76  ? 513 PHE B CD1   1 
ATOM   7969  C  CD2   . PHE B 1 521 ? 115.795 114.269 109.783 1.00 40.08  ? 513 PHE B CD2   1 
ATOM   7970  C  CE1   . PHE B 1 521 ? 116.181 114.585 112.487 1.00 41.46  ? 513 PHE B CE1   1 
ATOM   7971  C  CE2   . PHE B 1 521 ? 117.045 114.584 110.266 1.00 37.98  ? 513 PHE B CE2   1 
ATOM   7972  C  CZ    . PHE B 1 521 ? 117.237 114.741 111.619 1.00 38.47  ? 513 PHE B CZ    1 
ATOM   7973  N  N     . LEU B 1 522 ? 113.317 116.440 108.337 1.00 46.05  ? 514 LEU B N     1 
ATOM   7974  C  CA    . LEU B 1 522 ? 113.978 117.649 107.860 1.00 47.40  ? 514 LEU B CA    1 
ATOM   7975  C  C     . LEU B 1 522 ? 113.210 118.896 108.280 1.00 53.08  ? 514 LEU B C     1 
ATOM   7976  O  O     . LEU B 1 522 ? 113.806 119.883 108.729 1.00 55.76  ? 514 LEU B O     1 
ATOM   7977  C  CB    . LEU B 1 522 ? 114.129 117.594 106.340 1.00 46.06  ? 514 LEU B CB    1 
ATOM   7978  C  CG    . LEU B 1 522 ? 114.585 118.871 105.634 1.00 47.18  ? 514 LEU B CG    1 
ATOM   7979  C  CD1   . LEU B 1 522 ? 115.921 119.343 106.171 1.00 46.40  ? 514 LEU B CD1   1 
ATOM   7980  C  CD2   . LEU B 1 522 ? 114.662 118.641 104.137 1.00 49.07  ? 514 LEU B CD2   1 
ATOM   7981  N  N     . ARG B 1 523 ? 111.881 118.864 108.150 1.00 54.43  ? 515 ARG B N     1 
ATOM   7982  C  CA    . ARG B 1 523 ? 111.071 119.996 108.585 1.00 50.87  ? 515 ARG B CA    1 
ATOM   7983  C  C     . ARG B 1 523 ? 111.171 120.200 110.092 1.00 53.85  ? 515 ARG B C     1 
ATOM   7984  O  O     . ARG B 1 523 ? 111.258 121.339 110.567 1.00 58.66  ? 515 ARG B O     1 
ATOM   7985  C  CB    . ARG B 1 523 ? 109.615 119.800 108.163 1.00 51.24  ? 515 ARG B CB    1 
ATOM   7986  C  CG    . ARG B 1 523 ? 109.393 119.860 106.661 1.00 58.25  ? 515 ARG B CG    1 
ATOM   7987  C  CD    . ARG B 1 523 ? 107.918 120.000 106.325 1.00 62.44  ? 515 ARG B CD    1 
ATOM   7988  N  NE    . ARG B 1 523 ? 107.135 118.858 106.781 1.00 64.94  ? 515 ARG B NE    1 
ATOM   7989  C  CZ    . ARG B 1 523 ? 106.804 117.825 106.018 1.00 65.01  ? 515 ARG B CZ    1 
ATOM   7990  N  NH1   . ARG B 1 523 ? 107.175 117.754 104.751 1.00 57.72  ? 515 ARG B NH1   1 
ATOM   7991  N  NH2   . ARG B 1 523 ? 106.079 116.839 106.540 1.00 65.13  ? 515 ARG B NH2   1 
ATOM   7992  N  N     . TYR B 1 524 ? 111.157 119.108 110.861 1.00 49.50  ? 516 TYR B N     1 
ATOM   7993  C  CA    . TYR B 1 524 ? 111.280 119.222 112.312 1.00 48.06  ? 516 TYR B CA    1 
ATOM   7994  C  C     . TYR B 1 524 ? 112.624 119.818 112.710 1.00 49.79  ? 516 TYR B C     1 
ATOM   7995  O  O     . TYR B 1 524 ? 112.694 120.670 113.603 1.00 54.14  ? 516 TYR B O     1 
ATOM   7996  C  CB    . TYR B 1 524 ? 111.090 117.853 112.965 1.00 49.93  ? 516 TYR B CB    1 
ATOM   7997  C  CG    . TYR B 1 524 ? 111.419 117.828 114.442 1.00 53.95  ? 516 TYR B CG    1 
ATOM   7998  C  CD1   . TYR B 1 524 ? 110.489 118.235 115.386 1.00 55.15  ? 516 TYR B CD1   1 
ATOM   7999  C  CD2   . TYR B 1 524 ? 112.659 117.393 114.892 1.00 50.71  ? 516 TYR B CD2   1 
ATOM   8000  C  CE1   . TYR B 1 524 ? 110.784 118.216 116.734 1.00 52.19  ? 516 TYR B CE1   1 
ATOM   8001  C  CE2   . TYR B 1 524 ? 112.962 117.372 116.238 1.00 52.64  ? 516 TYR B CE2   1 
ATOM   8002  C  CZ    . TYR B 1 524 ? 112.021 117.784 117.154 1.00 54.37  ? 516 TYR B CZ    1 
ATOM   8003  O  OH    . TYR B 1 524 ? 112.318 117.763 118.497 1.00 57.60  ? 516 TYR B OH    1 
ATOM   8004  N  N     . ALA B 1 525 ? 113.703 119.377 112.064 1.00 49.01  ? 517 ALA B N     1 
ATOM   8005  C  CA    . ALA B 1 525 ? 115.033 119.851 112.425 1.00 50.42  ? 517 ALA B CA    1 
ATOM   8006  C  C     . ALA B 1 525 ? 115.237 121.301 112.015 1.00 53.02  ? 517 ALA B C     1 
ATOM   8007  O  O     . ALA B 1 525 ? 115.860 122.076 112.750 1.00 56.70  ? 517 ALA B O     1 
ATOM   8008  C  CB    . ALA B 1 525 ? 116.096 118.959 111.789 1.00 48.71  ? 517 ALA B CB    1 
ATOM   8009  N  N     . GLN B 1 526 ? 114.729 121.690 110.843 1.00 50.85  ? 518 GLN B N     1 
ATOM   8010  C  CA    . GLN B 1 526 ? 114.859 123.082 110.429 1.00 53.35  ? 518 GLN B CA    1 
ATOM   8011  C  C     . GLN B 1 526 ? 113.964 123.998 111.252 1.00 58.87  ? 518 GLN B C     1 
ATOM   8012  O  O     . GLN B 1 526 ? 114.260 125.190 111.392 1.00 63.10  ? 518 GLN B O     1 
ATOM   8013  C  CB    . GLN B 1 526 ? 114.548 123.219 108.940 1.00 55.89  ? 518 GLN B CB    1 
ATOM   8014  C  CG    . GLN B 1 526 ? 115.608 122.612 108.037 1.00 58.15  ? 518 GLN B CG    1 
ATOM   8015  C  CD    . GLN B 1 526 ? 115.314 122.820 106.566 1.00 56.36  ? 518 GLN B CD    1 
ATOM   8016  O  OE1   . GLN B 1 526 ? 114.184 123.117 106.182 1.00 60.84  ? 518 GLN B OE1   1 
ATOM   8017  N  NE2   . GLN B 1 526 ? 116.336 122.667 105.733 1.00 48.97  ? 518 GLN B NE2   1 
ATOM   8018  N  N     . GLY B 1 527 ? 112.878 123.468 111.803 1.00 57.55  ? 519 GLY B N     1 
ATOM   8019  C  CA    . GLY B 1 527 ? 111.971 124.224 112.637 1.00 56.36  ? 519 GLY B CA    1 
ATOM   8020  C  C     . GLY B 1 527 ? 112.279 124.203 114.118 1.00 59.46  ? 519 GLY B C     1 
ATOM   8021  O  O     . GLY B 1 527 ? 111.488 124.729 114.907 1.00 66.42  ? 519 GLY B O     1 
ATOM   8022  N  N     . SER B 1 528 ? 113.396 123.609 114.524 1.00 58.01  ? 520 SER B N     1 
ATOM   8023  C  CA    . SER B 1 528 ? 113.780 123.515 115.926 1.00 55.87  ? 520 SER B CA    1 
ATOM   8024  C  C     . SER B 1 528 ? 115.028 124.349 116.169 1.00 59.11  ? 520 SER B C     1 
ATOM   8025  O  O     . SER B 1 528 ? 116.033 124.188 115.468 1.00 60.01  ? 520 SER B O     1 
ATOM   8026  C  CB    . SER B 1 528 ? 114.030 122.060 116.327 1.00 55.79  ? 520 SER B CB    1 
ATOM   8027  O  OG    . SER B 1 528 ? 114.506 121.975 117.658 1.00 65.06  ? 520 SER B OG    1 
ATOM   8028  N  N     . GLU B 1 529 ? 114.962 125.240 117.160 1.00 58.25  ? 521 GLU B N     1 
ATOM   8029  C  CA    . GLU B 1 529 ? 116.110 126.085 117.471 1.00 61.11  ? 521 GLU B CA    1 
ATOM   8030  C  C     . GLU B 1 529 ? 117.273 125.265 118.016 1.00 60.98  ? 521 GLU B C     1 
ATOM   8031  O  O     . GLU B 1 529 ? 118.436 125.540 117.697 1.00 61.68  ? 521 GLU B O     1 
ATOM   8032  C  CB    . GLU B 1 529 ? 115.708 127.172 118.467 1.00 65.89  ? 521 GLU B CB    1 
ATOM   8033  C  CG    . GLU B 1 529 ? 116.842 128.112 118.847 1.00 72.28  ? 521 GLU B CG    1 
ATOM   8034  C  CD    . GLU B 1 529 ? 116.410 129.182 119.831 1.00 83.56  ? 521 GLU B CD    1 
ATOM   8035  O  OE1   . GLU B 1 529 ? 115.201 129.256 120.138 1.00 85.86  ? 521 GLU B OE1   1 
ATOM   8036  O  OE2   . GLU B 1 529 ? 117.279 129.947 120.299 1.00 86.86  ? 521 GLU B OE2   1 
ATOM   8037  N  N     . VAL B 1 530 ? 116.978 124.257 118.840 1.00 58.47  ? 522 VAL B N     1 
ATOM   8038  C  CA    . VAL B 1 530 ? 118.035 123.461 119.461 1.00 56.55  ? 522 VAL B CA    1 
ATOM   8039  C  C     . VAL B 1 530 ? 118.849 122.732 118.399 1.00 57.54  ? 522 VAL B C     1 
ATOM   8040  O  O     . VAL B 1 530 ? 120.085 122.742 118.423 1.00 59.02  ? 522 VAL B O     1 
ATOM   8041  C  CB    . VAL B 1 530 ? 117.434 122.478 120.481 1.00 55.64  ? 522 VAL B CB    1 
ATOM   8042  C  CG1   . VAL B 1 530 ? 118.522 121.599 121.073 1.00 55.75  ? 522 VAL B CG1   1 
ATOM   8043  C  CG2   . VAL B 1 530 ? 116.698 123.233 121.574 1.00 60.73  ? 522 VAL B CG2   1 
ATOM   8044  N  N     . LEU B 1 531 ? 118.167 122.092 117.447 1.00 55.74  ? 523 LEU B N     1 
ATOM   8045  C  CA    . LEU B 1 531 ? 118.874 121.326 116.426 1.00 53.43  ? 523 LEU B CA    1 
ATOM   8046  C  C     . LEU B 1 531 ? 119.613 122.240 115.455 1.00 54.92  ? 523 LEU B C     1 
ATOM   8047  O  O     . LEU B 1 531 ? 120.703 121.899 114.984 1.00 53.74  ? 523 LEU B O     1 
ATOM   8048  C  CB    . LEU B 1 531 ? 117.897 120.422 115.678 1.00 54.45  ? 523 LEU B CB    1 
ATOM   8049  C  CG    . LEU B 1 531 ? 117.130 119.420 116.540 1.00 50.61  ? 523 LEU B CG    1 
ATOM   8050  C  CD1   . LEU B 1 531 ? 116.333 118.467 115.670 1.00 53.73  ? 523 LEU B CD1   1 
ATOM   8051  C  CD2   . LEU B 1 531 ? 118.079 118.657 117.444 1.00 50.53  ? 523 LEU B CD2   1 
ATOM   8052  N  N     . MET B 1 532 ? 119.036 123.401 115.140 1.00 54.76  ? 524 MET B N     1 
ATOM   8053  C  CA    . MET B 1 532 ? 119.696 124.325 114.226 1.00 54.17  ? 524 MET B CA    1 
ATOM   8054  C  C     . MET B 1 532 ? 120.868 125.046 114.875 1.00 58.06  ? 524 MET B C     1 
ATOM   8055  O  O     . MET B 1 532 ? 121.746 125.540 114.161 1.00 60.47  ? 524 MET B O     1 
ATOM   8056  C  CB    . MET B 1 532 ? 118.695 125.346 113.688 1.00 57.12  ? 524 MET B CB    1 
ATOM   8057  C  CG    . MET B 1 532 ? 117.672 124.764 112.729 1.00 64.50  ? 524 MET B CG    1 
ATOM   8058  S  SD    . MET B 1 532 ? 118.427 123.958 111.303 1.00 72.74  ? 524 MET B SD    1 
ATOM   8059  C  CE    . MET B 1 532 ? 119.330 125.324 110.578 1.00 64.01  ? 524 MET B CE    1 
ATOM   8060  N  N     . SER B 1 533 ? 120.902 125.123 116.205 1.00 56.35  ? 525 SER B N     1 
ATOM   8061  C  CA    . SER B 1 533 ? 122.019 125.756 116.891 1.00 55.72  ? 525 SER B CA    1 
ATOM   8062  C  C     . SER B 1 533 ? 123.233 124.846 117.013 1.00 57.96  ? 525 SER B C     1 
ATOM   8063  O  O     . SER B 1 533 ? 124.322 125.334 117.335 1.00 57.76  ? 525 SER B O     1 
ATOM   8064  C  CB    . SER B 1 533 ? 121.583 126.218 118.282 1.00 61.61  ? 525 SER B CB    1 
ATOM   8065  O  OG    . SER B 1 533 ? 121.052 125.137 119.029 1.00 64.50  ? 525 SER B OG    1 
ATOM   8066  N  N     . ARG B 1 534 ? 123.076 123.550 116.764 1.00 60.08  ? 526 ARG B N     1 
ATOM   8067  C  CA    . ARG B 1 534 ? 124.159 122.581 116.860 1.00 57.03  ? 526 ARG B CA    1 
ATOM   8068  C  C     . ARG B 1 534 ? 124.501 122.066 115.470 1.00 55.08  ? 526 ARG B C     1 
ATOM   8069  O  O     . ARG B 1 534 ? 123.624 121.574 114.754 1.00 54.91  ? 526 ARG B O     1 
ATOM   8070  C  CB    . ARG B 1 534 ? 123.769 121.415 117.770 1.00 55.10  ? 526 ARG B CB    1 
ATOM   8071  C  CG    . ARG B 1 534 ? 123.516 121.807 119.213 1.00 53.93  ? 526 ARG B CG    1 
ATOM   8072  C  CD    . ARG B 1 534 ? 124.812 121.897 119.998 1.00 52.51  ? 526 ARG B CD    1 
ATOM   8073  N  NE    . ARG B 1 534 ? 125.501 120.613 120.041 1.00 47.85  ? 526 ARG B NE    1 
ATOM   8074  C  CZ    . ARG B 1 534 ? 125.197 119.629 120.876 1.00 51.14  ? 526 ARG B CZ    1 
ATOM   8075  N  NH1   . ARG B 1 534 ? 124.215 119.746 121.754 1.00 48.73  ? 526 ARG B NH1   1 
ATOM   8076  N  NH2   . ARG B 1 534 ? 125.894 118.498 120.826 1.00 50.13  ? 526 ARG B NH2   1 
ATOM   8077  N  N     . HIS B 1 535 ? 125.776 122.174 115.095 1.00 54.42  ? 527 HIS B N     1 
ATOM   8078  C  CA    . HIS B 1 535 ? 126.240 121.702 113.801 1.00 54.57  ? 527 HIS B CA    1 
ATOM   8079  C  C     . HIS B 1 535 ? 127.031 120.405 113.876 1.00 51.38  ? 527 HIS B C     1 
ATOM   8080  O  O     . HIS B 1 535 ? 127.182 119.735 112.849 1.00 50.68  ? 527 HIS B O     1 
ATOM   8081  C  CB    . HIS B 1 535 ? 127.103 122.774 113.121 1.00 56.46  ? 527 HIS B CB    1 
ATOM   8082  C  CG    . HIS B 1 535 ? 126.397 124.077 112.917 1.00 62.75  ? 527 HIS B CG    1 
ATOM   8083  N  ND1   . HIS B 1 535 ? 125.383 124.238 111.998 1.00 65.19  ? 527 HIS B ND1   1 
ATOM   8084  C  CD2   . HIS B 1 535 ? 126.560 125.282 113.512 1.00 66.81  ? 527 HIS B CD2   1 
ATOM   8085  C  CE1   . HIS B 1 535 ? 124.950 125.485 112.037 1.00 70.11  ? 527 HIS B CE1   1 
ATOM   8086  N  NE2   . HIS B 1 535 ? 125.648 126.140 112.947 1.00 73.23  ? 527 HIS B NE2   1 
ATOM   8087  N  N     . ASN B 1 536 ? 127.526 120.025 115.055 1.00 49.47  ? 528 ASN B N     1 
ATOM   8088  C  CA    . ASN B 1 536 ? 128.356 118.837 115.207 1.00 47.01  ? 528 ASN B CA    1 
ATOM   8089  C  C     . ASN B 1 536 ? 127.537 117.575 115.445 1.00 40.50  ? 528 ASN B C     1 
ATOM   8090  O  O     . ASN B 1 536 ? 128.039 116.619 116.050 1.00 40.92  ? 528 ASN B O     1 
ATOM   8091  C  CB    . ASN B 1 536 ? 129.367 119.042 116.336 1.00 47.72  ? 528 ASN B CB    1 
ATOM   8092  C  CG    . ASN B 1 536 ? 128.708 119.379 117.656 1.00 48.71  ? 528 ASN B CG    1 
ATOM   8093  O  OD1   . ASN B 1 536 ? 127.541 119.762 117.700 1.00 51.44  ? 528 ASN B OD1   1 
ATOM   8094  N  ND2   . ASN B 1 536 ? 129.459 119.246 118.742 1.00 50.51  ? 528 ASN B ND2   1 
ATOM   8095  N  N     . VAL B 1 537 ? 126.290 117.545 114.987 1.00 38.73  ? 529 VAL B N     1 
ATOM   8096  C  CA    . VAL B 1 537 ? 125.440 116.365 115.080 1.00 34.60  ? 529 VAL B CA    1 
ATOM   8097  C  C     . VAL B 1 537 ? 125.325 115.768 113.687 1.00 33.47  ? 529 VAL B C     1 
ATOM   8098  O  O     . VAL B 1 537 ? 124.812 116.415 112.766 1.00 37.85  ? 529 VAL B O     1 
ATOM   8099  C  CB    . VAL B 1 537 ? 124.056 116.703 115.651 1.00 34.72  ? 529 VAL B CB    1 
ATOM   8100  C  CG1   . VAL B 1 537 ? 123.250 115.433 115.860 1.00 33.52  ? 529 VAL B CG1   1 
ATOM   8101  C  CG2   . VAL B 1 537 ? 124.196 117.473 116.951 1.00 44.46  ? 529 VAL B CG2   1 
ATOM   8102  N  N     . GLY B 1 538 ? 125.803 114.538 113.531 1.00 28.04  ? 530 GLY B N     1 
ATOM   8103  C  CA    . GLY B 1 538 ? 125.762 113.870 112.246 1.00 28.96  ? 530 GLY B CA    1 
ATOM   8104  C  C     . GLY B 1 538 ? 124.509 113.046 112.055 1.00 27.54  ? 530 GLY B C     1 
ATOM   8105  O  O     . GLY B 1 538 ? 124.290 112.061 112.765 1.00 30.69  ? 530 GLY B O     1 
ATOM   8106  N  N     . TYR B 1 539 ? 123.675 113.439 111.098 1.00 28.07  ? 531 TYR B N     1 
ATOM   8107  C  CA    . TYR B 1 539 ? 122.430 112.741 110.804 1.00 26.94  ? 531 TYR B CA    1 
ATOM   8108  C  C     . TYR B 1 539 ? 122.648 111.873 109.572 1.00 29.43  ? 531 TYR B C     1 
ATOM   8109  O  O     . TYR B 1 539 ? 122.801 112.388 108.461 1.00 35.05  ? 531 TYR B O     1 
ATOM   8110  C  CB    . TYR B 1 539 ? 121.289 113.730 110.580 1.00 28.77  ? 531 TYR B CB    1 
ATOM   8111  C  CG    . TYR B 1 539 ? 121.123 114.749 111.683 1.00 30.10  ? 531 TYR B CG    1 
ATOM   8112  C  CD1   . TYR B 1 539 ? 120.361 114.467 112.807 1.00 31.63  ? 531 TYR B CD1   1 
ATOM   8113  C  CD2   . TYR B 1 539 ? 121.722 115.998 111.595 1.00 29.55  ? 531 TYR B CD2   1 
ATOM   8114  C  CE1   . TYR B 1 539 ? 120.202 115.397 113.812 1.00 34.58  ? 531 TYR B CE1   1 
ATOM   8115  C  CE2   . TYR B 1 539 ? 121.569 116.934 112.595 1.00 29.83  ? 531 TYR B CE2   1 
ATOM   8116  C  CZ    . TYR B 1 539 ? 120.808 116.628 113.701 1.00 35.38  ? 531 TYR B CZ    1 
ATOM   8117  O  OH    . TYR B 1 539 ? 120.654 117.559 114.701 1.00 40.23  ? 531 TYR B OH    1 
ATOM   8118  N  N     . HIS B 1 540 ? 122.658 110.560 109.766 1.00 26.51  ? 532 HIS B N     1 
ATOM   8119  C  CA    . HIS B 1 540 ? 122.825 109.604 108.679 1.00 25.35  ? 532 HIS B CA    1 
ATOM   8120  C  C     . HIS B 1 540 ? 121.511 108.854 108.522 1.00 27.40  ? 532 HIS B C     1 
ATOM   8121  O  O     . HIS B 1 540 ? 121.135 108.061 109.390 1.00 32.88  ? 532 HIS B O     1 
ATOM   8122  C  CB    . HIS B 1 540 ? 123.981 108.648 108.963 1.00 27.75  ? 532 HIS B CB    1 
ATOM   8123  C  CG    . HIS B 1 540 ? 125.217 109.331 109.458 1.00 30.18  ? 532 HIS B CG    1 
ATOM   8124  N  ND1   . HIS B 1 540 ? 125.910 110.253 108.705 1.00 31.55  ? 532 HIS B ND1   1 
ATOM   8125  C  CD2   . HIS B 1 540 ? 125.882 109.229 110.633 1.00 31.50  ? 532 HIS B CD2   1 
ATOM   8126  C  CE1   . HIS B 1 540 ? 126.949 110.690 109.394 1.00 32.75  ? 532 HIS B CE1   1 
ATOM   8127  N  NE2   . HIS B 1 540 ? 126.954 110.084 110.568 1.00 30.07  ? 532 HIS B NE2   1 
ATOM   8128  N  N     . ILE B 1 541 ? 120.814 109.103 107.421 1.00 30.66  ? 533 ILE B N     1 
ATOM   8129  C  CA    . ILE B 1 541 ? 119.499 108.519 107.195 1.00 34.37  ? 533 ILE B CA    1 
ATOM   8130  C  C     . ILE B 1 541 ? 119.662 107.227 106.410 1.00 32.74  ? 533 ILE B C     1 
ATOM   8131  O  O     . ILE B 1 541 ? 120.236 107.220 105.316 1.00 35.85  ? 533 ILE B O     1 
ATOM   8132  C  CB    . ILE B 1 541 ? 118.571 109.498 106.464 1.00 32.41  ? 533 ILE B CB    1 
ATOM   8133  C  CG1   . ILE B 1 541 ? 118.207 110.662 107.387 1.00 33.17  ? 533 ILE B CG1   1 
ATOM   8134  C  CG2   . ILE B 1 541 ? 117.322 108.782 105.977 1.00 35.06  ? 533 ILE B CG2   1 
ATOM   8135  C  CD1   . ILE B 1 541 ? 117.029 111.475 106.913 1.00 42.60  ? 533 ILE B CD1   1 
ATOM   8136  N  N     . VAL B 1 542 ? 119.161 106.134 106.971 1.00 29.54  ? 534 VAL B N     1 
ATOM   8137  C  CA    . VAL B 1 542 ? 119.138 104.835 106.315 1.00 34.61  ? 534 VAL B CA    1 
ATOM   8138  C  C     . VAL B 1 542 ? 117.686 104.545 105.966 1.00 38.83  ? 534 VAL B C     1 
ATOM   8139  O  O     . VAL B 1 542 ? 116.859 104.315 106.856 1.00 38.82  ? 534 VAL B O     1 
ATOM   8140  C  CB    . VAL B 1 542 ? 119.734 103.740 107.206 1.00 35.07  ? 534 VAL B CB    1 
ATOM   8141  C  CG1   . VAL B 1 542 ? 119.566 102.384 106.561 1.00 44.02  ? 534 VAL B CG1   1 
ATOM   8142  C  CG2   . VAL B 1 542 ? 121.201 104.025 107.481 1.00 34.16  ? 534 VAL B CG2   1 
ATOM   8143  N  N     . TYR B 1 543 ? 117.374 104.552 104.674 1.00 42.76  ? 535 TYR B N     1 
ATOM   8144  C  CA    . TYR B 1 543 ? 115.986 104.486 104.241 1.00 43.14  ? 535 TYR B CA    1 
ATOM   8145  C  C     . TYR B 1 543 ? 115.387 103.110 104.505 1.00 47.30  ? 535 TYR B C     1 
ATOM   8146  O  O     . TYR B 1 543 ? 116.070 102.085 104.445 1.00 50.87  ? 535 TYR B O     1 
ATOM   8147  C  CB    . TYR B 1 543 ? 115.876 104.849 102.762 1.00 40.88  ? 535 TYR B CB    1 
ATOM   8148  C  CG    . TYR B 1 543 ? 116.195 106.300 102.493 1.00 41.29  ? 535 TYR B CG    1 
ATOM   8149  C  CD1   . TYR B 1 543 ? 115.225 107.281 102.635 1.00 44.40  ? 535 TYR B CD1   1 
ATOM   8150  C  CD2   . TYR B 1 543 ? 117.470 106.692 102.114 1.00 39.97  ? 535 TYR B CD2   1 
ATOM   8151  C  CE1   . TYR B 1 543 ? 115.512 108.609 102.397 1.00 47.82  ? 535 TYR B CE1   1 
ATOM   8152  C  CE2   . TYR B 1 543 ? 117.768 108.018 101.875 1.00 41.85  ? 535 TYR B CE2   1 
ATOM   8153  C  CZ    . TYR B 1 543 ? 116.785 108.972 102.018 1.00 47.10  ? 535 TYR B CZ    1 
ATOM   8154  O  OH    . TYR B 1 543 ? 117.076 110.294 101.779 1.00 47.32  ? 535 TYR B OH    1 
ATOM   8155  N  N     . LYS B 1 544 ? 114.091 103.103 104.805 1.00 48.40  ? 536 LYS B N     1 
ATOM   8156  C  CA    . LYS B 1 544 ? 113.420 101.889 105.245 1.00 50.35  ? 536 LYS B CA    1 
ATOM   8157  C  C     . LYS B 1 544 ? 113.350 100.854 104.131 1.00 54.40  ? 536 LYS B C     1 
ATOM   8158  O  O     . LYS B 1 544 ? 113.086 101.177 102.969 1.00 56.24  ? 536 LYS B O     1 
ATOM   8159  C  CB    . LYS B 1 544 ? 112.010 102.209 105.740 1.00 51.72  ? 536 LYS B CB    1 
ATOM   8160  C  CG    . LYS B 1 544 ? 111.967 103.008 107.029 1.00 50.38  ? 536 LYS B CG    1 
ATOM   8161  C  CD    . LYS B 1 544 ? 110.548 103.105 107.562 1.00 52.99  ? 536 LYS B CD    1 
ATOM   8162  C  CE    . LYS B 1 544 ? 110.511 103.794 108.914 1.00 58.32  ? 536 LYS B CE    1 
ATOM   8163  N  NZ    . LYS B 1 544 ? 109.127 103.880 109.455 1.00 66.51  ? 536 LYS B NZ    1 
ATOM   8164  N  N     . GLU B 1 545 ? 113.587 99.599  104.501 1.00 58.16  ? 537 GLU B N     1 
ATOM   8165  C  CA    . GLU B 1 545 ? 113.456 98.471  103.593 1.00 60.21  ? 537 GLU B CA    1 
ATOM   8166  C  C     . GLU B 1 545 ? 113.294 97.215  104.434 1.00 64.82  ? 537 GLU B C     1 
ATOM   8167  O  O     . GLU B 1 545 ? 113.912 97.090  105.493 1.00 65.50  ? 537 GLU B O     1 
ATOM   8168  C  CB    . GLU B 1 545 ? 114.671 98.349  102.665 1.00 63.92  ? 537 GLU B CB    1 
ATOM   8169  C  CG    . GLU B 1 545 ? 114.579 97.207  101.668 1.00 71.70  ? 537 GLU B CG    1 
ATOM   8170  C  CD    . GLU B 1 545 ? 115.758 97.165  100.719 1.00 78.15  ? 537 GLU B CD    1 
ATOM   8171  O  OE1   . GLU B 1 545 ? 116.586 98.100  100.754 1.00 79.30  ? 537 GLU B OE1   1 
ATOM   8172  O  OE2   . GLU B 1 545 ? 115.858 96.197  99.937  1.00 74.96  ? 537 GLU B OE2   1 
ATOM   8173  N  N     . GLY B 1 546 ? 112.462 96.296  103.963 1.00 66.68  ? 538 GLY B N     1 
ATOM   8174  C  CA    . GLY B 1 546 ? 112.211 95.081  104.701 1.00 71.73  ? 538 GLY B CA    1 
ATOM   8175  C  C     . GLY B 1 546 ? 111.167 95.270  105.785 1.00 74.67  ? 538 GLY B C     1 
ATOM   8176  O  O     . GLY B 1 546 ? 110.466 96.283  105.860 1.00 70.48  ? 538 GLY B O     1 
ATOM   8177  N  N     . GLN B 1 547 ? 111.073 94.257  106.649 1.00 77.64  ? 539 GLN B N     1 
ATOM   8178  C  CA    . GLN B 1 547 ? 110.065 94.229  107.698 1.00 75.32  ? 539 GLN B CA    1 
ATOM   8179  C  C     . GLN B 1 547 ? 110.613 94.484  109.093 1.00 73.69  ? 539 GLN B C     1 
ATOM   8180  O  O     . GLN B 1 547 ? 109.838 94.858  109.979 1.00 77.06  ? 539 GLN B O     1 
ATOM   8181  C  CB    . GLN B 1 547 ? 109.339 92.876  107.700 1.00 76.98  ? 539 GLN B CB    1 
ATOM   8182  C  CG    . GLN B 1 547 ? 108.695 92.514  106.376 1.00 81.26  ? 539 GLN B CG    1 
ATOM   8183  C  CD    . GLN B 1 547 ? 108.011 91.163  106.415 1.00 86.92  ? 539 GLN B CD    1 
ATOM   8184  O  OE1   . GLN B 1 547 ? 108.082 90.449  107.414 1.00 86.78  ? 539 GLN B OE1   1 
ATOM   8185  N  NE2   . GLN B 1 547 ? 107.344 90.805  105.325 1.00 88.96  ? 539 GLN B NE2   1 
ATOM   8186  N  N     . PHE B 1 548 ? 111.908 94.296  109.314 1.00 72.21  ? 540 PHE B N     1 
ATOM   8187  C  CA    . PHE B 1 548 ? 112.490 94.362  110.646 1.00 70.54  ? 540 PHE B CA    1 
ATOM   8188  C  C     . PHE B 1 548 ? 113.357 95.604  110.796 1.00 67.89  ? 540 PHE B C     1 
ATOM   8189  O  O     . PHE B 1 548 ? 113.669 96.303  109.829 1.00 67.38  ? 540 PHE B O     1 
ATOM   8190  C  CB    . PHE B 1 548 ? 113.307 93.101  110.938 1.00 72.34  ? 540 PHE B CB    1 
ATOM   8191  C  CG    . PHE B 1 548 ? 112.553 91.833  110.699 1.00 77.45  ? 540 PHE B CG    1 
ATOM   8192  C  CD1   . PHE B 1 548 ? 111.692 91.334  111.658 1.00 82.49  ? 540 PHE B CD1   1 
ATOM   8193  C  CD2   . PHE B 1 548 ? 112.696 91.142  109.510 1.00 84.82  ? 540 PHE B CD2   1 
ATOM   8194  C  CE1   . PHE B 1 548 ? 110.993 90.168  111.438 1.00 88.93  ? 540 PHE B CE1   1 
ATOM   8195  C  CE2   . PHE B 1 548 ? 111.998 89.977  109.285 1.00 90.45  ? 540 PHE B CE2   1 
ATOM   8196  C  CZ    . PHE B 1 548 ? 111.145 89.488  110.250 1.00 91.74  ? 540 PHE B CZ    1 
ATOM   8197  N  N     . TYR B 1 549 ? 113.746 95.868  112.042 1.00 64.04  ? 541 TYR B N     1 
ATOM   8198  C  CA    . TYR B 1 549 ? 114.528 97.050  112.370 1.00 60.30  ? 541 TYR B CA    1 
ATOM   8199  C  C     . TYR B 1 549 ? 116.008 96.691  112.347 1.00 60.97  ? 541 TYR B C     1 
ATOM   8200  O  O     . TYR B 1 549 ? 116.452 95.894  113.186 1.00 61.43  ? 541 TYR B O     1 
ATOM   8201  C  CB    . TYR B 1 549 ? 114.129 97.587  113.736 1.00 59.52  ? 541 TYR B CB    1 
ATOM   8202  C  CG    . TYR B 1 549 ? 114.790 98.892  114.104 1.00 53.58  ? 541 TYR B CG    1 
ATOM   8203  C  CD1   . TYR B 1 549 ? 114.342 100.090 113.571 1.00 53.68  ? 541 TYR B CD1   1 
ATOM   8204  C  CD2   . TYR B 1 549 ? 115.854 98.926  114.992 1.00 50.89  ? 541 TYR B CD2   1 
ATOM   8205  C  CE1   . TYR B 1 549 ? 114.941 101.285 113.905 1.00 52.57  ? 541 TYR B CE1   1 
ATOM   8206  C  CE2   . TYR B 1 549 ? 116.458 100.116 115.333 1.00 46.64  ? 541 TYR B CE2   1 
ATOM   8207  C  CZ    . TYR B 1 549 ? 115.997 101.292 114.787 1.00 46.15  ? 541 TYR B CZ    1 
ATOM   8208  O  OH    . TYR B 1 549 ? 116.596 102.482 115.123 1.00 44.71  ? 541 TYR B OH    1 
ATOM   8209  N  N     . PRO B 1 550 ? 116.800 97.241  111.427 1.00 59.42  ? 542 PRO B N     1 
ATOM   8210  C  CA    . PRO B 1 550 ? 118.242 96.928  111.361 1.00 60.50  ? 542 PRO B CA    1 
ATOM   8211  C  C     . PRO B 1 550 ? 119.048 97.715  112.391 1.00 54.89  ? 542 PRO B C     1 
ATOM   8212  O  O     . PRO B 1 550 ? 119.758 98.674  112.098 1.00 54.90  ? 542 PRO B O     1 
ATOM   8213  C  CB    . PRO B 1 550 ? 118.601 97.318  109.927 1.00 57.84  ? 542 PRO B CB    1 
ATOM   8214  C  CG    . PRO B 1 550 ? 117.679 98.447  109.627 1.00 54.23  ? 542 PRO B CG    1 
ATOM   8215  C  CD    . PRO B 1 550 ? 116.385 98.147  110.342 1.00 57.13  ? 542 PRO B CD    1 
ATOM   8216  N  N     . VAL B 1 551 ? 118.928 97.289  113.649 1.00 52.35  ? 543 VAL B N     1 
ATOM   8217  C  CA    . VAL B 1 551 ? 119.571 98.007  114.747 1.00 51.95  ? 543 VAL B CA    1 
ATOM   8218  C  C     . VAL B 1 551 ? 121.089 97.950  114.611 1.00 52.90  ? 543 VAL B C     1 
ATOM   8219  O  O     . VAL B 1 551 ? 121.783 98.965  114.756 1.00 52.53  ? 543 VAL B O     1 
ATOM   8220  C  CB    . VAL B 1 551 ? 119.093 97.445  116.098 1.00 52.08  ? 543 VAL B CB    1 
ATOM   8221  C  CG1   . VAL B 1 551 ? 119.149 95.927  116.092 1.00 55.50  ? 543 VAL B CG1   1 
ATOM   8222  C  CG2   . VAL B 1 551 ? 119.925 98.003  117.229 1.00 51.81  ? 543 VAL B CG2   1 
ATOM   8223  N  N     . ASN B 1 552 ? 121.627 96.765  114.317 1.00 52.93  ? 544 ASN B N     1 
ATOM   8224  C  CA    . ASN B 1 552 ? 123.074 96.621  114.194 1.00 48.66  ? 544 ASN B CA    1 
ATOM   8225  C  C     . ASN B 1 552 ? 123.606 97.346  112.965 1.00 47.64  ? 544 ASN B C     1 
ATOM   8226  O  O     . ASN B 1 552 ? 124.691 97.936  113.009 1.00 46.75  ? 544 ASN B O     1 
ATOM   8227  C  CB    . ASN B 1 552 ? 123.453 95.144  114.153 1.00 50.28  ? 544 ASN B CB    1 
ATOM   8228  C  CG    . ASN B 1 552 ? 123.361 94.484  115.511 1.00 54.21  ? 544 ASN B CG    1 
ATOM   8229  O  OD1   . ASN B 1 552 ? 123.594 95.118  116.538 1.00 52.99  ? 544 ASN B OD1   1 
ATOM   8230  N  ND2   . ASN B 1 552 ? 123.020 93.202  115.523 1.00 56.69  ? 544 ASN B ND2   1 
ATOM   8231  N  N     . LEU B 1 553 ? 122.864 97.306  111.856 1.00 49.31  ? 545 LEU B N     1 
ATOM   8232  C  CA    . LEU B 1 553 ? 123.276 98.053  110.673 1.00 49.63  ? 545 LEU B CA    1 
ATOM   8233  C  C     . LEU B 1 553 ? 123.322 99.548  110.957 1.00 46.68  ? 545 LEU B C     1 
ATOM   8234  O  O     . LEU B 1 553 ? 124.271 100.235 110.561 1.00 48.91  ? 545 LEU B O     1 
ATOM   8235  C  CB    . LEU B 1 553 ? 122.331 97.758  109.509 1.00 50.42  ? 545 LEU B CB    1 
ATOM   8236  C  CG    . LEU B 1 553 ? 122.459 98.683  108.297 1.00 52.01  ? 545 LEU B CG    1 
ATOM   8237  C  CD1   . LEU B 1 553 ? 123.827 98.542  107.649 1.00 52.21  ? 545 LEU B CD1   1 
ATOM   8238  C  CD2   . LEU B 1 553 ? 121.355 98.409  107.295 1.00 54.23  ? 545 LEU B CD2   1 
ATOM   8239  N  N     . LEU B 1 554 ? 122.305 100.067 111.647 1.00 45.90  ? 546 LEU B N     1 
ATOM   8240  C  CA    . LEU B 1 554 ? 122.291 101.482 112.001 1.00 45.83  ? 546 LEU B CA    1 
ATOM   8241  C  C     . LEU B 1 554 ? 123.444 101.829 112.933 1.00 44.37  ? 546 LEU B C     1 
ATOM   8242  O  O     . LEU B 1 554 ? 124.070 102.887 112.793 1.00 44.75  ? 546 LEU B O     1 
ATOM   8243  C  CB    . LEU B 1 554 ? 120.954 101.845 112.641 1.00 44.73  ? 546 LEU B CB    1 
ATOM   8244  C  CG    . LEU B 1 554 ? 119.756 101.855 111.693 1.00 45.03  ? 546 LEU B CG    1 
ATOM   8245  C  CD1   . LEU B 1 554 ? 118.464 101.866 112.478 1.00 49.62  ? 546 LEU B CD1   1 
ATOM   8246  C  CD2   . LEU B 1 554 ? 119.826 103.057 110.772 1.00 40.09  ? 546 LEU B CD2   1 
ATOM   8247  N  N     . ARG B 1 555 ? 123.737 100.953 113.895 1.00 46.05  ? 547 ARG B N     1 
ATOM   8248  C  CA    . ARG B 1 555 ? 124.865 101.192 114.788 1.00 44.29  ? 547 ARG B CA    1 
ATOM   8249  C  C     . ARG B 1 555 ? 126.179 101.218 114.021 1.00 46.33  ? 547 ARG B C     1 
ATOM   8250  O  O     . ARG B 1 555 ? 127.039 102.065 114.283 1.00 46.58  ? 547 ARG B O     1 
ATOM   8251  C  CB    . ARG B 1 555 ? 124.899 100.131 115.885 1.00 42.41  ? 547 ARG B CB    1 
ATOM   8252  C  CG    . ARG B 1 555 ? 123.846 100.332 116.953 1.00 43.97  ? 547 ARG B CG    1 
ATOM   8253  C  CD    . ARG B 1 555 ? 123.665 99.089  117.795 1.00 42.44  ? 547 ARG B CD    1 
ATOM   8254  N  NE    . ARG B 1 555 ? 122.775 99.331  118.923 1.00 44.84  ? 547 ARG B NE    1 
ATOM   8255  C  CZ    . ARG B 1 555 ? 122.247 98.378  119.676 1.00 52.23  ? 547 ARG B CZ    1 
ATOM   8256  N  NH1   . ARG B 1 555 ? 122.484 97.100  119.437 1.00 53.27  ? 547 ARG B NH1   1 
ATOM   8257  N  NH2   . ARG B 1 555 ? 121.453 98.716  120.688 1.00 58.80  ? 547 ARG B NH2   1 
ATOM   8258  N  N     . ASN B 1 556 ? 126.355 100.296 113.073 1.00 45.41  ? 548 ASN B N     1 
ATOM   8259  C  CA    . ASN B 1 556 ? 127.570 100.290 112.263 1.00 45.15  ? 548 ASN B CA    1 
ATOM   8260  C  C     . ASN B 1 556 ? 127.682 101.557 111.428 1.00 41.93  ? 548 ASN B C     1 
ATOM   8261  O  O     . ASN B 1 556 ? 128.769 102.134 111.304 1.00 41.56  ? 548 ASN B O     1 
ATOM   8262  C  CB    . ASN B 1 556 ? 127.599 99.055  111.365 1.00 48.59  ? 548 ASN B CB    1 
ATOM   8263  C  CG    . ASN B 1 556 ? 127.828 97.777  112.141 1.00 48.71  ? 548 ASN B CG    1 
ATOM   8264  O  OD1   . ASN B 1 556 ? 128.480 97.782  113.183 1.00 48.28  ? 548 ASN B OD1   1 
ATOM   8265  N  ND2   . ASN B 1 556 ? 127.296 96.673  111.634 1.00 48.36  ? 548 ASN B ND2   1 
ATOM   8266  N  N     . VAL B 1 557 ? 126.567 102.004 110.847 1.00 44.09  ? 549 VAL B N     1 
ATOM   8267  C  CA    . VAL B 1 557 ? 126.578 103.234 110.060 1.00 42.09  ? 549 VAL B CA    1 
ATOM   8268  C  C     . VAL B 1 557 ? 126.968 104.419 110.933 1.00 41.83  ? 549 VAL B C     1 
ATOM   8269  O  O     . VAL B 1 557 ? 127.780 105.262 110.535 1.00 44.32  ? 549 VAL B O     1 
ATOM   8270  C  CB    . VAL B 1 557 ? 125.210 103.453 109.388 1.00 36.45  ? 549 VAL B CB    1 
ATOM   8271  C  CG1   . VAL B 1 557 ? 125.146 104.830 108.756 1.00 39.63  ? 549 VAL B CG1   1 
ATOM   8272  C  CG2   . VAL B 1 557 ? 124.957 102.384 108.342 1.00 36.90  ? 549 VAL B CG2   1 
ATOM   8273  N  N     . ALA B 1 558 ? 126.399 104.501 112.136 1.00 39.79  ? 550 ALA B N     1 
ATOM   8274  C  CA    . ALA B 1 558 ? 126.722 105.607 113.031 1.00 41.49  ? 550 ALA B CA    1 
ATOM   8275  C  C     . ALA B 1 558 ? 128.181 105.563 113.474 1.00 43.58  ? 550 ALA B C     1 
ATOM   8276  O  O     . ALA B 1 558 ? 128.843 106.604 113.544 1.00 41.12  ? 550 ALA B O     1 
ATOM   8277  C  CB    . ALA B 1 558 ? 125.791 105.587 114.242 1.00 38.29  ? 550 ALA B CB    1 
ATOM   8278  N  N     . MET B 1 559 ? 128.695 104.370 113.782 1.00 43.01  ? 551 MET B N     1 
ATOM   8279  C  CA    . MET B 1 559 ? 130.067 104.246 114.265 1.00 36.95  ? 551 MET B CA    1 
ATOM   8280  C  C     . MET B 1 559 ? 131.078 104.564 113.173 1.00 44.25  ? 551 MET B C     1 
ATOM   8281  O  O     . MET B 1 559 ? 132.072 105.256 113.421 1.00 45.90  ? 551 MET B O     1 
ATOM   8282  C  CB    . MET B 1 559 ? 130.310 102.837 114.798 1.00 35.88  ? 551 MET B CB    1 
ATOM   8283  C  CG    . MET B 1 559 ? 129.563 102.500 116.065 1.00 51.24  ? 551 MET B CG    1 
ATOM   8284  S  SD    . MET B 1 559 ? 129.362 100.720 116.247 1.00 58.63  ? 551 MET B SD    1 
ATOM   8285  C  CE    . MET B 1 559 ? 131.019 100.154 115.885 1.00 44.93  ? 551 MET B CE    1 
ATOM   8286  N  N     . LYS B 1 560 ? 130.844 104.059 111.961 1.00 45.16  ? 552 LYS B N     1 
ATOM   8287  C  CA    . LYS B 1 560 ? 131.838 104.149 110.899 1.00 39.96  ? 552 LYS B CA    1 
ATOM   8288  C  C     . LYS B 1 560 ? 132.111 105.584 110.470 1.00 44.17  ? 552 LYS B C     1 
ATOM   8289  O  O     . LYS B 1 560 ? 133.188 105.864 109.934 1.00 44.06  ? 552 LYS B O     1 
ATOM   8290  C  CB    . LYS B 1 560 ? 131.376 103.316 109.702 1.00 43.60  ? 552 LYS B CB    1 
ATOM   8291  C  CG    . LYS B 1 560 ? 132.413 103.137 108.609 1.00 51.86  ? 552 LYS B CG    1 
ATOM   8292  C  CD    . LYS B 1 560 ? 131.868 102.276 107.482 1.00 55.58  ? 552 LYS B CD    1 
ATOM   8293  C  CE    . LYS B 1 560 ? 132.878 102.129 106.358 1.00 61.54  ? 552 LYS B CE    1 
ATOM   8294  N  NZ    . LYS B 1 560 ? 132.345 101.287 105.252 1.00 69.57  ? 552 LYS B NZ    1 
ATOM   8295  N  N     . HIS B 1 561 ? 131.179 106.499 110.708 1.00 43.24  ? 553 HIS B N     1 
ATOM   8296  C  CA    . HIS B 1 561 ? 131.259 107.855 110.184 1.00 40.30  ? 553 HIS B CA    1 
ATOM   8297  C  C     . HIS B 1 561 ? 131.351 108.885 111.304 1.00 41.50  ? 553 HIS B C     1 
ATOM   8298  O  O     . HIS B 1 561 ? 130.681 109.919 111.279 1.00 42.83  ? 553 HIS B O     1 
ATOM   8299  C  CB    . HIS B 1 561 ? 130.074 108.142 109.269 1.00 40.08  ? 553 HIS B CB    1 
ATOM   8300  C  CG    . HIS B 1 561 ? 129.919 107.144 108.165 1.00 42.42  ? 553 HIS B CG    1 
ATOM   8301  N  ND1   . HIS B 1 561 ? 130.777 107.087 107.088 1.00 47.50  ? 553 HIS B ND1   1 
ATOM   8302  C  CD2   . HIS B 1 561 ? 129.015 106.153 107.978 1.00 41.78  ? 553 HIS B CD2   1 
ATOM   8303  C  CE1   . HIS B 1 561 ? 130.405 106.108 106.283 1.00 47.12  ? 553 HIS B CE1   1 
ATOM   8304  N  NE2   . HIS B 1 561 ? 129.338 105.527 106.799 1.00 48.97  ? 553 HIS B NE2   1 
ATOM   8305  N  N     . ILE B 1 562 ? 132.186 108.613 112.300 1.00 43.63  ? 554 ILE B N     1 
ATOM   8306  C  CA    . ILE B 1 562 ? 132.449 109.559 113.369 1.00 45.93  ? 554 ILE B CA    1 
ATOM   8307  C  C     . ILE B 1 562 ? 133.709 110.338 113.024 1.00 51.28  ? 554 ILE B C     1 
ATOM   8308  O  O     . ILE B 1 562 ? 134.505 109.942 112.169 1.00 55.58  ? 554 ILE B O     1 
ATOM   8309  C  CB    . ILE B 1 562 ? 132.588 108.864 114.741 1.00 47.14  ? 554 ILE B CB    1 
ATOM   8310  C  CG1   . ILE B 1 562 ? 133.839 107.989 114.768 1.00 53.70  ? 554 ILE B CG1   1 
ATOM   8311  C  CG2   . ILE B 1 562 ? 131.356 108.034 115.042 1.00 45.55  ? 554 ILE B CG2   1 
ATOM   8312  C  CD1   . ILE B 1 562 ? 134.089 107.327 116.101 1.00 52.73  ? 554 ILE B CD1   1 
ATOM   8313  N  N     . SER B 1 563 ? 133.895 111.471 113.697 1.00 50.65  ? 555 SER B N     1 
ATOM   8314  C  CA    . SER B 1 563 ? 135.032 112.348 113.448 1.00 58.05  ? 555 SER B CA    1 
ATOM   8315  C  C     . SER B 1 563 ? 135.996 112.415 114.624 1.00 63.42  ? 555 SER B C     1 
ATOM   8316  O  O     . SER B 1 563 ? 136.861 113.296 114.652 1.00 68.66  ? 555 SER B O     1 
ATOM   8317  C  CB    . SER B 1 563 ? 134.543 113.754 113.095 1.00 57.73  ? 555 SER B CB    1 
ATOM   8318  O  OG    . SER B 1 563 ? 133.667 113.723 111.983 1.00 60.71  ? 555 SER B OG    1 
ATOM   8319  N  N     . THR B 1 564 ? 135.876 111.511 115.590 1.00 57.68  ? 556 THR B N     1 
ATOM   8320  C  CA    . THR B 1 564 ? 136.672 111.564 116.804 1.00 56.12  ? 556 THR B CA    1 
ATOM   8321  C  C     . THR B 1 564 ? 137.334 110.220 117.062 1.00 61.61  ? 556 THR B C     1 
ATOM   8322  O  O     . THR B 1 564 ? 136.811 109.177 116.656 1.00 63.74  ? 556 THR B O     1 
ATOM   8323  C  CB    . THR B 1 564 ? 135.807 111.950 118.012 1.00 59.27  ? 556 THR B CB    1 
ATOM   8324  O  OG1   . THR B 1 564 ? 134.751 110.995 118.166 1.00 58.35  ? 556 THR B OG1   1 
ATOM   8325  C  CG2   . THR B 1 564 ? 135.211 113.332 117.818 1.00 58.32  ? 556 THR B CG2   1 
ATOM   8326  N  N     . PRO B 1 565 ? 138.491 110.215 117.730 1.00 61.14  ? 557 PRO B N     1 
ATOM   8327  C  CA    . PRO B 1 565 ? 139.173 108.939 118.003 1.00 61.04  ? 557 PRO B CA    1 
ATOM   8328  C  C     . PRO B 1 565 ? 138.374 107.981 118.869 1.00 59.46  ? 557 PRO B C     1 
ATOM   8329  O  O     . PRO B 1 565 ? 138.523 106.762 118.722 1.00 58.47  ? 557 PRO B O     1 
ATOM   8330  C  CB    . PRO B 1 565 ? 140.469 109.380 118.698 1.00 60.98  ? 557 PRO B CB    1 
ATOM   8331  C  CG    . PRO B 1 565 ? 140.183 110.746 119.218 1.00 59.83  ? 557 PRO B CG    1 
ATOM   8332  C  CD    . PRO B 1 565 ? 139.267 111.367 118.218 1.00 57.62  ? 557 PRO B CD    1 
ATOM   8333  N  N     . TYR B 1 566 ? 137.537 108.485 119.771 1.00 56.38  ? 558 TYR B N     1 
ATOM   8334  C  CA    . TYR B 1 566 ? 136.788 107.646 120.694 1.00 54.26  ? 558 TYR B CA    1 
ATOM   8335  C  C     . TYR B 1 566 ? 135.295 107.865 120.507 1.00 52.26  ? 558 TYR B C     1 
ATOM   8336  O  O     . TYR B 1 566 ? 134.850 108.960 120.152 1.00 54.48  ? 558 TYR B O     1 
ATOM   8337  C  CB    . TYR B 1 566 ? 137.180 107.934 122.148 1.00 58.66  ? 558 TYR B CB    1 
ATOM   8338  C  CG    . TYR B 1 566 ? 138.669 107.895 122.383 1.00 61.72  ? 558 TYR B CG    1 
ATOM   8339  C  CD1   . TYR B 1 566 ? 139.317 106.700 122.657 1.00 62.62  ? 558 TYR B CD1   1 
ATOM   8340  C  CD2   . TYR B 1 566 ? 139.430 109.054 122.322 1.00 64.81  ? 558 TYR B CD2   1 
ATOM   8341  C  CE1   . TYR B 1 566 ? 140.679 106.661 122.867 1.00 69.79  ? 558 TYR B CE1   1 
ATOM   8342  C  CE2   . TYR B 1 566 ? 140.791 109.026 122.530 1.00 68.40  ? 558 TYR B CE2   1 
ATOM   8343  C  CZ    . TYR B 1 566 ? 141.411 107.827 122.803 1.00 73.02  ? 558 TYR B CZ    1 
ATOM   8344  O  OH    . TYR B 1 566 ? 142.769 107.796 123.013 1.00 82.77  ? 558 TYR B OH    1 
ATOM   8345  N  N     . MET B 1 567 ? 134.524 106.808 120.744 1.00 49.03  ? 559 MET B N     1 
ATOM   8346  C  CA    . MET B 1 567 ? 133.081 106.857 120.571 1.00 48.10  ? 559 MET B CA    1 
ATOM   8347  C  C     . MET B 1 567 ? 132.384 106.185 121.744 1.00 45.73  ? 559 MET B C     1 
ATOM   8348  O  O     . MET B 1 567 ? 132.846 105.160 122.253 1.00 48.02  ? 559 MET B O     1 
ATOM   8349  C  CB    . MET B 1 567 ? 132.653 106.192 119.259 1.00 48.74  ? 559 MET B CB    1 
ATOM   8350  C  CG    . MET B 1 567 ? 133.094 104.751 119.115 1.00 47.86  ? 559 MET B CG    1 
ATOM   8351  S  SD    . MET B 1 567 ? 132.535 104.020 117.571 1.00 48.93  ? 559 MET B SD    1 
ATOM   8352  C  CE    . MET B 1 567 ? 133.193 102.367 117.732 1.00 52.72  ? 559 MET B CE    1 
ATOM   8353  N  N     . PHE B 1 568 ? 131.264 106.772 122.158 1.00 42.67  ? 560 PHE B N     1 
ATOM   8354  C  CA    . PHE B 1 568 ? 130.421 106.237 123.221 1.00 39.86  ? 560 PHE B CA    1 
ATOM   8355  C  C     . PHE B 1 568 ? 129.213 105.576 122.567 1.00 39.53  ? 560 PHE B C     1 
ATOM   8356  O  O     . PHE B 1 568 ? 128.380 106.256 121.959 1.00 38.68  ? 560 PHE B O     1 
ATOM   8357  C  CB    . PHE B 1 568 ? 130.005 107.356 124.175 1.00 39.83  ? 560 PHE B CB    1 
ATOM   8358  C  CG    . PHE B 1 568 ? 129.032 106.933 125.243 1.00 40.62  ? 560 PHE B CG    1 
ATOM   8359  C  CD1   . PHE B 1 568 ? 128.962 105.618 125.671 1.00 42.26  ? 560 PHE B CD1   1 
ATOM   8360  C  CD2   . PHE B 1 568 ? 128.183 107.862 125.819 1.00 37.33  ? 560 PHE B CD2   1 
ATOM   8361  C  CE1   . PHE B 1 568 ? 128.066 105.241 126.645 1.00 43.80  ? 560 PHE B CE1   1 
ATOM   8362  C  CE2   . PHE B 1 568 ? 127.288 107.488 126.795 1.00 40.84  ? 560 PHE B CE2   1 
ATOM   8363  C  CZ    . PHE B 1 568 ? 127.232 106.177 127.208 1.00 45.78  ? 560 PHE B CZ    1 
ATOM   8364  N  N     . LEU B 1 569 ? 129.111 104.252 122.696 1.00 41.16  ? 561 LEU B N     1 
ATOM   8365  C  CA    . LEU B 1 569 ? 128.030 103.499 122.061 1.00 41.35  ? 561 LEU B CA    1 
ATOM   8366  C  C     . LEU B 1 569 ? 126.783 103.561 122.945 1.00 42.15  ? 561 LEU B C     1 
ATOM   8367  O  O     . LEU B 1 569 ? 126.357 102.584 123.563 1.00 42.89  ? 561 LEU B O     1 
ATOM   8368  C  CB    . LEU B 1 569 ? 128.460 102.063 121.797 1.00 43.94  ? 561 LEU B CB    1 
ATOM   8369  C  CG    . LEU B 1 569 ? 129.713 101.891 120.937 1.00 43.44  ? 561 LEU B CG    1 
ATOM   8370  C  CD1   . LEU B 1 569 ? 129.925 100.431 120.590 1.00 45.33  ? 561 LEU B CD1   1 
ATOM   8371  C  CD2   . LEU B 1 569 ? 129.616 102.734 119.681 1.00 42.95  ? 561 LEU B CD2   1 
ATOM   8372  N  N     . SER B 1 570 ? 126.190 104.749 122.984 1.00 43.91  ? 562 SER B N     1 
ATOM   8373  C  CA    . SER B 1 570 ? 125.025 105.006 123.819 1.00 46.58  ? 562 SER B CA    1 
ATOM   8374  C  C     . SER B 1 570 ? 123.754 104.551 123.107 1.00 44.43  ? 562 SER B C     1 
ATOM   8375  O  O     . SER B 1 570 ? 123.789 103.806 122.125 1.00 46.81  ? 562 SER B O     1 
ATOM   8376  C  CB    . SER B 1 570 ? 124.982 106.476 124.222 1.00 48.54  ? 562 SER B CB    1 
ATOM   8377  O  OG    . SER B 1 570 ? 123.800 106.767 124.943 1.00 53.30  ? 562 SER B OG    1 
ATOM   8378  N  N     . ASP B 1 571 ? 122.606 104.994 123.610 1.00 47.04  ? 563 ASP B N     1 
ATOM   8379  C  CA    . ASP B 1 571 ? 121.315 104.694 123.015 1.00 50.59  ? 563 ASP B CA    1 
ATOM   8380  C  C     . ASP B 1 571 ? 120.476 105.964 123.036 1.00 49.25  ? 563 ASP B C     1 
ATOM   8381  O  O     . ASP B 1 571 ? 120.711 106.875 123.834 1.00 46.45  ? 563 ASP B O     1 
ATOM   8382  C  CB    . ASP B 1 571 ? 120.588 103.553 123.738 1.00 51.55  ? 563 ASP B CB    1 
ATOM   8383  C  CG    . ASP B 1 571 ? 119.728 102.726 122.806 1.00 57.68  ? 563 ASP B CG    1 
ATOM   8384  O  OD1   . ASP B 1 571 ? 119.098 103.306 121.897 1.00 57.00  ? 563 ASP B OD1   1 
ATOM   8385  O  OD2   . ASP B 1 571 ? 119.685 101.492 122.979 1.00 60.15  ? 563 ASP B OD2   1 
ATOM   8386  N  N     . ILE B 1 572 ? 119.493 106.022 122.134 1.00 49.83  ? 564 ILE B N     1 
ATOM   8387  C  CA    . ILE B 1 572 ? 118.684 107.229 122.008 1.00 48.94  ? 564 ILE B CA    1 
ATOM   8388  C  C     . ILE B 1 572 ? 117.720 107.389 123.175 1.00 47.23  ? 564 ILE B C     1 
ATOM   8389  O  O     . ILE B 1 572 ? 117.247 108.501 123.431 1.00 45.93  ? 564 ILE B O     1 
ATOM   8390  C  CB    . ILE B 1 572 ? 117.923 107.235 120.668 1.00 47.84  ? 564 ILE B CB    1 
ATOM   8391  C  CG1   . ILE B 1 572 ? 117.894 108.646 120.083 1.00 41.17  ? 564 ILE B CG1   1 
ATOM   8392  C  CG2   . ILE B 1 572 ? 116.507 106.710 120.837 1.00 50.20  ? 564 ILE B CG2   1 
ATOM   8393  C  CD1   . ILE B 1 572 ? 119.242 109.133 119.626 1.00 41.83  ? 564 ILE B CD1   1 
ATOM   8394  N  N     . ASP B 1 573 ? 117.422 106.311 123.897 1.00 50.36  ? 565 ASP B N     1 
ATOM   8395  C  CA    . ASP B 1 573 ? 116.509 106.358 125.030 1.00 46.73  ? 565 ASP B CA    1 
ATOM   8396  C  C     . ASP B 1 573 ? 117.195 106.750 126.328 1.00 39.16  ? 565 ASP B C     1 
ATOM   8397  O  O     . ASP B 1 573 ? 116.523 106.856 127.358 1.00 46.24  ? 565 ASP B O     1 
ATOM   8398  C  CB    . ASP B 1 573 ? 115.824 105.001 125.212 1.00 48.58  ? 565 ASP B CB    1 
ATOM   8399  C  CG    . ASP B 1 573 ? 114.880 104.670 124.082 1.00 54.78  ? 565 ASP B CG    1 
ATOM   8400  O  OD1   . ASP B 1 573 ? 114.229 105.597 123.556 1.00 52.98  ? 565 ASP B OD1   1 
ATOM   8401  O  OD2   . ASP B 1 573 ? 114.787 103.480 123.718 1.00 56.19  ? 565 ASP B OD2   1 
ATOM   8402  N  N     . PHE B 1 574 ? 118.504 106.967 126.309 1.00 40.43  ? 566 PHE B N     1 
ATOM   8403  C  CA    . PHE B 1 574 ? 119.276 107.244 127.510 1.00 40.20  ? 566 PHE B CA    1 
ATOM   8404  C  C     . PHE B 1 574 ? 119.723 108.697 127.516 1.00 39.23  ? 566 PHE B C     1 
ATOM   8405  O  O     . PHE B 1 574 ? 120.385 109.151 126.577 1.00 45.87  ? 566 PHE B O     1 
ATOM   8406  C  CB    . PHE B 1 574 ? 120.494 106.325 127.598 1.00 41.16  ? 566 PHE B CB    1 
ATOM   8407  C  CG    . PHE B 1 574 ? 120.169 104.918 127.997 1.00 42.21  ? 566 PHE B CG    1 
ATOM   8408  C  CD1   . PHE B 1 574 ? 119.532 104.063 127.117 1.00 44.97  ? 566 PHE B CD1   1 
ATOM   8409  C  CD2   . PHE B 1 574 ? 120.511 104.446 129.251 1.00 42.09  ? 566 PHE B CD2   1 
ATOM   8410  C  CE1   . PHE B 1 574 ? 119.235 102.768 127.483 1.00 46.71  ? 566 PHE B CE1   1 
ATOM   8411  C  CE2   . PHE B 1 574 ? 120.218 103.152 129.622 1.00 45.76  ? 566 PHE B CE2   1 
ATOM   8412  C  CZ    . PHE B 1 574 ? 119.578 102.312 128.737 1.00 47.80  ? 566 PHE B CZ    1 
ATOM   8413  N  N     . LEU B 1 575 ? 119.366 109.411 128.565 1.00 37.17  ? 567 LEU B N     1 
ATOM   8414  C  CA    . LEU B 1 575 ? 119.863 110.758 128.793 1.00 39.89  ? 567 LEU B CA    1 
ATOM   8415  C  C     . LEU B 1 575 ? 121.106 110.702 129.662 1.00 42.77  ? 567 LEU B C     1 
ATOM   8416  O  O     . LEU B 1 575 ? 121.069 110.101 130.746 1.00 52.23  ? 567 LEU B O     1 
ATOM   8417  C  CB    . LEU B 1 575 ? 118.801 111.622 129.465 1.00 44.81  ? 567 LEU B CB    1 
ATOM   8418  C  CG    . LEU B 1 575 ? 117.585 111.996 128.618 1.00 48.20  ? 567 LEU B CG    1 
ATOM   8419  C  CD1   . LEU B 1 575 ? 116.657 112.914 129.392 1.00 53.20  ? 567 LEU B CD1   1 
ATOM   8420  C  CD2   . LEU B 1 575 ? 118.027 112.648 127.323 1.00 47.06  ? 567 LEU B CD2   1 
ATOM   8421  N  N     . PRO B 1 576 ? 122.215 111.278 129.218 1.00 39.25  ? 568 PRO B N     1 
ATOM   8422  C  CA    . PRO B 1 576 ? 123.428 111.298 130.037 1.00 45.71  ? 568 PRO B CA    1 
ATOM   8423  C  C     . PRO B 1 576 ? 123.384 112.424 131.060 1.00 49.84  ? 568 PRO B C     1 
ATOM   8424  O  O     . PRO B 1 576 ? 122.503 113.283 131.050 1.00 53.55  ? 568 PRO B O     1 
ATOM   8425  C  CB    . PRO B 1 576 ? 124.533 111.531 129.006 1.00 42.71  ? 568 PRO B CB    1 
ATOM   8426  C  CG    . PRO B 1 576 ? 123.868 112.358 127.963 1.00 44.34  ? 568 PRO B CG    1 
ATOM   8427  C  CD    . PRO B 1 576 ? 122.439 111.876 127.890 1.00 43.24  ? 568 PRO B CD    1 
ATOM   8428  N  N     . MET B 1 577 ? 124.365 112.404 131.956 1.00 46.25  ? 569 MET B N     1 
ATOM   8429  C  CA    . MET B 1 577 ? 124.486 113.457 132.949 1.00 47.75  ? 569 MET B CA    1 
ATOM   8430  C  C     . MET B 1 577 ? 125.088 114.710 132.323 1.00 54.32  ? 569 MET B C     1 
ATOM   8431  O  O     . MET B 1 577 ? 125.698 114.671 131.251 1.00 60.35  ? 569 MET B O     1 
ATOM   8432  C  CB    . MET B 1 577 ? 125.350 113.001 134.123 1.00 52.95  ? 569 MET B CB    1 
ATOM   8433  C  CG    . MET B 1 577 ? 126.840 113.097 133.863 1.00 51.16  ? 569 MET B CG    1 
ATOM   8434  S  SD    . MET B 1 577 ? 127.832 112.768 135.328 1.00 59.86  ? 569 MET B SD    1 
ATOM   8435  C  CE    . MET B 1 577 ? 129.463 113.199 134.730 1.00 58.30  ? 569 MET B CE    1 
ATOM   8436  N  N     . TYR B 1 578 ? 124.903 115.834 133.007 1.00 55.44  ? 570 TYR B N     1 
ATOM   8437  C  CA    . TYR B 1 578 ? 125.502 117.083 132.559 1.00 57.73  ? 570 TYR B CA    1 
ATOM   8438  C  C     . TYR B 1 578 ? 127.015 117.030 132.724 1.00 60.37  ? 570 TYR B C     1 
ATOM   8439  O  O     . TYR B 1 578 ? 127.529 116.563 133.744 1.00 58.02  ? 570 TYR B O     1 
ATOM   8440  C  CB    . TYR B 1 578 ? 124.929 118.262 133.344 1.00 59.17  ? 570 TYR B CB    1 
ATOM   8441  C  CG    . TYR B 1 578 ? 123.447 118.478 133.138 1.00 61.25  ? 570 TYR B CG    1 
ATOM   8442  C  CD1   . TYR B 1 578 ? 122.513 117.796 133.904 1.00 63.92  ? 570 TYR B CD1   1 
ATOM   8443  C  CD2   . TYR B 1 578 ? 122.983 119.369 132.180 1.00 60.99  ? 570 TYR B CD2   1 
ATOM   8444  C  CE1   . TYR B 1 578 ? 121.159 117.991 133.721 1.00 64.79  ? 570 TYR B CE1   1 
ATOM   8445  C  CE2   . TYR B 1 578 ? 121.630 119.570 131.989 1.00 61.06  ? 570 TYR B CE2   1 
ATOM   8446  C  CZ    . TYR B 1 578 ? 120.724 118.879 132.763 1.00 63.45  ? 570 TYR B CZ    1 
ATOM   8447  O  OH    . TYR B 1 578 ? 119.375 119.075 132.578 1.00 66.18  ? 570 TYR B OH    1 
ATOM   8448  N  N     . GLY B 1 579 ? 127.729 117.512 131.711 1.00 62.00  ? 571 GLY B N     1 
ATOM   8449  C  CA    . GLY B 1 579 ? 129.176 117.511 131.755 1.00 60.52  ? 571 GLY B CA    1 
ATOM   8450  C  C     . GLY B 1 579 ? 129.828 116.166 131.539 1.00 59.79  ? 571 GLY B C     1 
ATOM   8451  O  O     . GLY B 1 579 ? 131.025 116.028 131.807 1.00 60.75  ? 571 GLY B O     1 
ATOM   8452  N  N     . LEU B 1 580 ? 129.079 115.164 131.070 1.00 59.31  ? 572 LEU B N     1 
ATOM   8453  C  CA    . LEU B 1 580 ? 129.668 113.854 130.817 1.00 55.37  ? 572 LEU B CA    1 
ATOM   8454  C  C     . LEU B 1 580 ? 130.691 113.905 129.689 1.00 55.41  ? 572 LEU B C     1 
ATOM   8455  O  O     . LEU B 1 580 ? 131.606 113.077 129.646 1.00 56.80  ? 572 LEU B O     1 
ATOM   8456  C  CB    . LEU B 1 580 ? 128.572 112.837 130.497 1.00 51.34  ? 572 LEU B CB    1 
ATOM   8457  C  CG    . LEU B 1 580 ? 129.018 111.387 130.311 1.00 44.63  ? 572 LEU B CG    1 
ATOM   8458  C  CD1   . LEU B 1 580 ? 129.731 110.891 131.554 1.00 48.55  ? 572 LEU B CD1   1 
ATOM   8459  C  CD2   . LEU B 1 580 ? 127.839 110.493 129.979 1.00 43.25  ? 572 LEU B CD2   1 
ATOM   8460  N  N     . TYR B 1 581 ? 130.555 114.868 128.777 1.00 53.80  ? 573 TYR B N     1 
ATOM   8461  C  CA    . TYR B 1 581 ? 131.507 114.999 127.679 1.00 52.32  ? 573 TYR B CA    1 
ATOM   8462  C  C     . TYR B 1 581 ? 132.913 115.272 128.203 1.00 57.47  ? 573 TYR B C     1 
ATOM   8463  O  O     . TYR B 1 581 ? 133.866 114.552 127.873 1.00 61.06  ? 573 TYR B O     1 
ATOM   8464  C  CB    . TYR B 1 581 ? 131.037 116.111 126.737 1.00 51.36  ? 573 TYR B CB    1 
ATOM   8465  C  CG    . TYR B 1 581 ? 131.989 116.467 125.621 1.00 54.95  ? 573 TYR B CG    1 
ATOM   8466  C  CD1   . TYR B 1 581 ? 132.191 115.608 124.550 1.00 54.65  ? 573 TYR B CD1   1 
ATOM   8467  C  CD2   . TYR B 1 581 ? 132.665 117.679 125.623 1.00 59.34  ? 573 TYR B CD2   1 
ATOM   8468  C  CE1   . TYR B 1 581 ? 133.055 115.938 123.524 1.00 57.55  ? 573 TYR B CE1   1 
ATOM   8469  C  CE2   . TYR B 1 581 ? 133.528 118.018 124.601 1.00 61.61  ? 573 TYR B CE2   1 
ATOM   8470  C  CZ    . TYR B 1 581 ? 133.719 117.144 123.555 1.00 61.68  ? 573 TYR B CZ    1 
ATOM   8471  O  OH    . TYR B 1 581 ? 134.580 117.480 122.537 1.00 61.28  ? 573 TYR B OH    1 
ATOM   8472  N  N     . GLU B 1 582 ? 133.056 116.291 129.053 1.00 58.04  ? 574 GLU B N     1 
ATOM   8473  C  CA    . GLU B 1 582 ? 134.361 116.598 129.628 1.00 61.57  ? 574 GLU B CA    1 
ATOM   8474  C  C     . GLU B 1 582 ? 134.837 115.495 130.563 1.00 61.93  ? 574 GLU B C     1 
ATOM   8475  O  O     . GLU B 1 582 ? 136.041 115.220 130.634 1.00 63.54  ? 574 GLU B O     1 
ATOM   8476  C  CB    . GLU B 1 582 ? 134.308 117.935 130.364 1.00 60.28  ? 574 GLU B CB    1 
ATOM   8477  C  CG    . GLU B 1 582 ? 133.998 119.118 129.465 1.00 67.46  ? 574 GLU B CG    1 
ATOM   8478  C  CD    . GLU B 1 582 ? 135.089 119.376 128.443 1.00 76.00  ? 574 GLU B CD    1 
ATOM   8479  O  OE1   . GLU B 1 582 ? 136.266 119.080 128.737 1.00 76.45  ? 574 GLU B OE1   1 
ATOM   8480  O  OE2   . GLU B 1 582 ? 134.768 119.872 127.343 1.00 79.32  ? 574 GLU B OE2   1 
ATOM   8481  N  N     . TYR B 1 583 ? 133.915 114.851 131.282 1.00 58.24  ? 575 TYR B N     1 
ATOM   8482  C  CA    . TYR B 1 583 ? 134.308 113.761 132.166 1.00 57.92  ? 575 TYR B CA    1 
ATOM   8483  C  C     . TYR B 1 583 ? 134.914 112.606 131.381 1.00 63.22  ? 575 TYR B C     1 
ATOM   8484  O  O     . TYR B 1 583 ? 135.935 112.042 131.784 1.00 68.26  ? 575 TYR B O     1 
ATOM   8485  C  CB    . TYR B 1 583 ? 133.112 113.286 132.987 1.00 59.31  ? 575 TYR B CB    1 
ATOM   8486  C  CG    . TYR B 1 583 ? 133.469 112.227 134.003 1.00 63.15  ? 575 TYR B CG    1 
ATOM   8487  C  CD1   . TYR B 1 583 ? 134.232 112.541 135.120 1.00 64.98  ? 575 TYR B CD1   1 
ATOM   8488  C  CD2   . TYR B 1 583 ? 133.044 110.915 133.847 1.00 61.85  ? 575 TYR B CD2   1 
ATOM   8489  C  CE1   . TYR B 1 583 ? 134.565 111.579 136.052 1.00 67.12  ? 575 TYR B CE1   1 
ATOM   8490  C  CE2   . TYR B 1 583 ? 133.371 109.945 134.774 1.00 69.31  ? 575 TYR B CE2   1 
ATOM   8491  C  CZ    . TYR B 1 583 ? 134.132 110.282 135.874 1.00 71.41  ? 575 TYR B CZ    1 
ATOM   8492  O  OH    . TYR B 1 583 ? 134.459 109.318 136.800 1.00 69.15  ? 575 TYR B OH    1 
ATOM   8493  N  N     . LEU B 1 584 ? 134.309 112.249 130.246 1.00 62.16  ? 576 LEU B N     1 
ATOM   8494  C  CA    . LEU B 1 584 ? 134.865 111.178 129.423 1.00 58.11  ? 576 LEU B CA    1 
ATOM   8495  C  C     . LEU B 1 584 ? 136.161 111.612 128.750 1.00 61.10  ? 576 LEU B C     1 
ATOM   8496  O  O     . LEU B 1 584 ? 137.080 110.799 128.579 1.00 63.22  ? 576 LEU B O     1 
ATOM   8497  C  CB    . LEU B 1 584 ? 133.841 110.727 128.384 1.00 53.51  ? 576 LEU B CB    1 
ATOM   8498  C  CG    . LEU B 1 584 ? 132.609 110.012 128.939 1.00 47.60  ? 576 LEU B CG    1 
ATOM   8499  C  CD1   . LEU B 1 584 ? 131.646 109.653 127.823 1.00 43.68  ? 576 LEU B CD1   1 
ATOM   8500  C  CD2   . LEU B 1 584 ? 133.019 108.774 129.711 1.00 45.12  ? 576 LEU B CD2   1 
ATOM   8501  N  N     . ARG B 1 585 ? 136.257 112.886 128.357 1.00 61.82  ? 577 ARG B N     1 
ATOM   8502  C  CA    . ARG B 1 585 ? 137.508 113.381 127.790 1.00 65.80  ? 577 ARG B CA    1 
ATOM   8503  C  C     . ARG B 1 585 ? 138.645 113.320 128.801 1.00 70.37  ? 577 ARG B C     1 
ATOM   8504  O  O     . ARG B 1 585 ? 139.803 113.115 128.421 1.00 76.74  ? 577 ARG B O     1 
ATOM   8505  C  CB    . ARG B 1 585 ? 137.331 114.808 127.276 1.00 65.84  ? 577 ARG B CB    1 
ATOM   8506  C  CG    . ARG B 1 585 ? 136.529 114.905 125.992 1.00 66.21  ? 577 ARG B CG    1 
ATOM   8507  C  CD    . ARG B 1 585 ? 136.545 116.317 125.440 1.00 69.56  ? 577 ARG B CD    1 
ATOM   8508  N  NE    . ARG B 1 585 ? 137.899 116.779 125.162 1.00 74.87  ? 577 ARG B NE    1 
ATOM   8509  C  CZ    . ARG B 1 585 ? 138.190 117.946 124.604 1.00 80.67  ? 577 ARG B CZ    1 
ATOM   8510  N  NH1   . ARG B 1 585 ? 137.243 118.795 124.243 1.00 78.58  ? 577 ARG B NH1   1 
ATOM   8511  N  NH2   . ARG B 1 585 ? 139.464 118.268 124.401 1.00 84.02  ? 577 ARG B NH2   1 
ATOM   8512  N  N     . LYS B 1 586 ? 138.345 113.519 130.085 1.00 66.75  ? 578 LYS B N     1 
ATOM   8513  C  CA    . LYS B 1 586 ? 139.368 113.343 131.111 1.00 66.33  ? 578 LYS B CA    1 
ATOM   8514  C  C     . LYS B 1 586 ? 139.627 111.867 131.398 1.00 70.08  ? 578 LYS B C     1 
ATOM   8515  O  O     . LYS B 1 586 ? 140.768 111.473 131.664 1.00 77.30  ? 578 LYS B O     1 
ATOM   8516  C  CB    . LYS B 1 586 ? 138.962 114.068 132.392 1.00 71.35  ? 578 LYS B CB    1 
ATOM   8517  C  CG    . LYS B 1 586 ? 138.928 115.581 132.266 1.00 72.95  ? 578 LYS B CG    1 
ATOM   8518  C  CD    . LYS B 1 586 ? 138.569 116.233 133.590 1.00 77.45  ? 578 LYS B CD    1 
ATOM   8519  C  CE    . LYS B 1 586 ? 138.555 117.748 133.472 1.00 82.79  ? 578 LYS B CE    1 
ATOM   8520  N  NZ    . LYS B 1 586 ? 138.219 118.401 134.768 1.00 88.15  ? 578 LYS B NZ    1 
ATOM   8521  N  N     . SER B 1 587 ? 138.580 111.041 131.346 1.00 68.23  ? 579 SER B N     1 
ATOM   8522  C  CA    . SER B 1 587 ? 138.720 109.632 131.692 1.00 69.19  ? 579 SER B CA    1 
ATOM   8523  C  C     . SER B 1 587 ? 139.541 108.869 130.663 1.00 73.80  ? 579 SER B C     1 
ATOM   8524  O  O     . SER B 1 587 ? 140.270 107.940 131.026 1.00 76.09  ? 579 SER B O     1 
ATOM   8525  C  CB    . SER B 1 587 ? 137.343 108.990 131.848 1.00 63.00  ? 579 SER B CB    1 
ATOM   8526  O  OG    . SER B 1 587 ? 136.604 109.621 132.878 1.00 65.78  ? 579 SER B OG    1 
ATOM   8527  N  N     . VAL B 1 588 ? 139.431 109.226 129.381 1.00 72.58  ? 580 VAL B N     1 
ATOM   8528  C  CA    . VAL B 1 588 ? 140.229 108.537 128.369 1.00 73.20  ? 580 VAL B CA    1 
ATOM   8529  C  C     . VAL B 1 588 ? 141.713 108.802 128.592 1.00 77.39  ? 580 VAL B C     1 
ATOM   8530  O  O     . VAL B 1 588 ? 142.556 107.923 128.373 1.00 80.71  ? 580 VAL B O     1 
ATOM   8531  C  CB    . VAL B 1 588 ? 139.784 108.937 126.949 1.00 74.24  ? 580 VAL B CB    1 
ATOM   8532  C  CG1   . VAL B 1 588 ? 138.384 108.425 126.668 1.00 73.82  ? 580 VAL B CG1   1 
ATOM   8533  C  CG2   . VAL B 1 588 ? 139.851 110.439 126.761 1.00 74.63  ? 580 VAL B CG2   1 
ATOM   8534  N  N     . ILE B 1 589 ? 142.058 110.014 129.033 1.00 76.97  ? 581 ILE B N     1 
ATOM   8535  C  CA    . ILE B 1 589 ? 143.446 110.315 129.367 1.00 77.39  ? 581 ILE B CA    1 
ATOM   8536  C  C     . ILE B 1 589 ? 143.859 109.586 130.639 1.00 76.15  ? 581 ILE B C     1 
ATOM   8537  O  O     . ILE B 1 589 ? 144.963 109.036 130.726 1.00 76.70  ? 581 ILE B O     1 
ATOM   8538  C  CB    . ILE B 1 589 ? 143.648 111.835 129.499 1.00 75.21  ? 581 ILE B CB    1 
ATOM   8539  C  CG1   . ILE B 1 589 ? 143.379 112.528 128.163 1.00 76.14  ? 581 ILE B CG1   1 
ATOM   8540  C  CG2   . ILE B 1 589 ? 145.052 112.147 129.988 1.00 76.02  ? 581 ILE B CG2   1 
ATOM   8541  C  CD1   . ILE B 1 589 ? 143.592 114.025 128.202 1.00 77.67  ? 581 ILE B CD1   1 
ATOM   8542  N  N     . GLN B 1 590 ? 142.982 109.573 131.646 1.00 74.45  ? 582 GLN B N     1 
ATOM   8543  C  CA    . GLN B 1 590 ? 143.332 108.969 132.928 1.00 78.02  ? 582 GLN B CA    1 
ATOM   8544  C  C     . GLN B 1 590 ? 143.565 107.468 132.798 1.00 80.31  ? 582 GLN B C     1 
ATOM   8545  O  O     . GLN B 1 590 ? 144.518 106.929 133.373 1.00 84.61  ? 582 GLN B O     1 
ATOM   8546  C  CB    . GLN B 1 590 ? 142.238 109.256 133.957 1.00 78.38  ? 582 GLN B CB    1 
ATOM   8547  C  CG    . GLN B 1 590 ? 142.507 108.667 135.331 1.00 77.34  ? 582 GLN B CG    1 
ATOM   8548  C  CD    . GLN B 1 590 ? 141.391 108.954 136.315 1.00 82.61  ? 582 GLN B CD    1 
ATOM   8549  O  OE1   . GLN B 1 590 ? 140.467 109.711 136.020 1.00 84.62  ? 582 GLN B OE1   1 
ATOM   8550  N  NE2   . GLN B 1 590 ? 141.470 108.346 137.493 1.00 82.54  ? 582 GLN B NE2   1 
ATOM   8551  N  N     . LEU B 1 591 ? 142.709 106.775 132.049 1.00 77.10  ? 583 LEU B N     1 
ATOM   8552  C  CA    . LEU B 1 591 ? 142.820 105.330 131.905 1.00 79.34  ? 583 LEU B CA    1 
ATOM   8553  C  C     . LEU B 1 591 ? 143.692 104.905 130.731 1.00 85.07  ? 583 LEU B C     1 
ATOM   8554  O  O     . LEU B 1 591 ? 143.966 103.708 130.592 1.00 85.53  ? 583 LEU B O     1 
ATOM   8555  C  CB    . LEU B 1 591 ? 141.430 104.703 131.754 1.00 75.60  ? 583 LEU B CB    1 
ATOM   8556  C  CG    . LEU B 1 591 ? 140.485 104.863 132.944 1.00 69.71  ? 583 LEU B CG    1 
ATOM   8557  C  CD1   . LEU B 1 591 ? 139.204 104.079 132.720 1.00 65.28  ? 583 LEU B CD1   1 
ATOM   8558  C  CD2   . LEU B 1 591 ? 141.168 104.424 134.226 1.00 75.65  ? 583 LEU B CD2   1 
ATOM   8559  N  N     . ASP B 1 592 ? 144.127 105.846 129.896 1.00 84.42  ? 584 ASP B N     1 
ATOM   8560  C  CA    . ASP B 1 592 ? 144.999 105.569 128.754 1.00 87.99  ? 584 ASP B CA    1 
ATOM   8561  C  C     . ASP B 1 592 ? 144.392 104.497 127.847 1.00 90.20  ? 584 ASP B C     1 
ATOM   8562  O  O     . ASP B 1 592 ? 144.935 103.405 127.669 1.00 92.28  ? 584 ASP B O     1 
ATOM   8563  C  CB    . ASP B 1 592 ? 146.401 105.170 129.223 1.00 91.25  ? 584 ASP B CB    1 
ATOM   8564  C  CG    . ASP B 1 592 ? 147.407 105.129 128.088 1.00 96.33  ? 584 ASP B CG    1 
ATOM   8565  O  OD1   . ASP B 1 592 ? 147.082 105.610 126.983 1.00 95.60  ? 584 ASP B OD1   1 
ATOM   8566  O  OD2   . ASP B 1 592 ? 148.524 104.613 128.302 1.00 96.00  ? 584 ASP B OD2   1 
ATOM   8567  N  N     . LEU B 1 593 ? 143.234 104.829 127.274 1.00 88.96  ? 585 LEU B N     1 
ATOM   8568  C  CA    . LEU B 1 593 ? 142.567 103.916 126.355 1.00 87.43  ? 585 LEU B CA    1 
ATOM   8569  C  C     . LEU B 1 593 ? 143.237 103.855 124.991 1.00 85.78  ? 585 LEU B C     1 
ATOM   8570  O  O     . LEU B 1 593 ? 142.924 102.951 124.209 1.00 85.89  ? 585 LEU B O     1 
ATOM   8571  C  CB    . LEU B 1 593 ? 141.102 104.316 126.182 1.00 84.78  ? 585 LEU B CB    1 
ATOM   8572  C  CG    . LEU B 1 593 ? 140.072 103.464 126.923 1.00 83.35  ? 585 LEU B CG    1 
ATOM   8573  C  CD1   . LEU B 1 593 ? 140.280 103.553 128.423 1.00 79.49  ? 585 LEU B CD1   1 
ATOM   8574  C  CD2   . LEU B 1 593 ? 138.665 103.890 126.545 1.00 75.73  ? 585 LEU B CD2   1 
ATOM   8575  N  N     . ALA B 1 594 ? 144.135 104.791 124.682 1.00 85.81  ? 586 ALA B N     1 
ATOM   8576  C  CA    . ALA B 1 594 ? 144.788 104.789 123.378 1.00 89.04  ? 586 ALA B CA    1 
ATOM   8577  C  C     . ALA B 1 594 ? 145.680 103.567 123.200 1.00 91.10  ? 586 ALA B C     1 
ATOM   8578  O  O     . ALA B 1 594 ? 145.705 102.962 122.122 1.00 91.44  ? 586 ALA B O     1 
ATOM   8579  C  CB    . ALA B 1 594 ? 145.595 106.073 123.193 1.00 89.95  ? 586 ALA B CB    1 
ATOM   8580  N  N     . ASN B 1 595 ? 146.418 103.188 124.242 1.00 90.37  ? 587 ASN B N     1 
ATOM   8581  C  CA    . ASN B 1 595 ? 147.400 102.116 124.154 1.00 90.47  ? 587 ASN B CA    1 
ATOM   8582  C  C     . ASN B 1 595 ? 146.913 100.810 124.768 1.00 87.41  ? 587 ASN B C     1 
ATOM   8583  O  O     . ASN B 1 595 ? 147.682 99.846  124.837 1.00 88.39  ? 587 ASN B O     1 
ATOM   8584  C  CB    . ASN B 1 595 ? 148.707 102.550 124.820 1.00 94.31  ? 587 ASN B CB    1 
ATOM   8585  C  CG    . ASN B 1 595 ? 149.211 103.880 124.299 1.00 97.17  ? 587 ASN B CG    1 
ATOM   8586  O  OD1   . ASN B 1 595 ? 149.958 103.936 123.323 1.00 99.27  ? 587 ASN B OD1   1 
ATOM   8587  N  ND2   . ASN B 1 595 ? 148.801 104.963 124.949 1.00 94.20  ? 587 ASN B ND2   1 
ATOM   8588  N  N     . THR B 1 596 ? 145.661 100.749 125.215 1.00 85.93  ? 588 THR B N     1 
ATOM   8589  C  CA    . THR B 1 596 ? 145.130 99.553  125.851 1.00 83.59  ? 588 THR B CA    1 
ATOM   8590  C  C     . THR B 1 596 ? 143.742 99.259  125.302 1.00 81.58  ? 588 THR B C     1 
ATOM   8591  O  O     . THR B 1 596 ? 143.035 100.152 124.830 1.00 86.09  ? 588 THR B O     1 
ATOM   8592  C  CB    . THR B 1 596 ? 145.065 99.699  127.378 1.00 84.52  ? 588 THR B CB    1 
ATOM   8593  O  OG1   . THR B 1 596 ? 144.356 100.898 127.716 1.00 88.96  ? 588 THR B OG1   1 
ATOM   8594  C  CG2   . THR B 1 596 ? 146.463 99.754  127.976 1.00 84.21  ? 588 THR B CG2   1 
ATOM   8595  N  N     . LYS B 1 597 ? 143.359 97.983  125.368 1.00 75.09  ? 589 LYS B N     1 
ATOM   8596  C  CA    . LYS B 1 597 ? 142.023 97.549  124.958 1.00 72.56  ? 589 LYS B CA    1 
ATOM   8597  C  C     . LYS B 1 597 ? 141.110 97.574  126.180 1.00 70.03  ? 589 LYS B C     1 
ATOM   8598  O  O     . LYS B 1 597 ? 140.873 96.565  126.847 1.00 70.06  ? 589 LYS B O     1 
ATOM   8599  C  CB    . LYS B 1 597 ? 142.074 96.165  124.324 1.00 70.89  ? 589 LYS B CB    1 
ATOM   8600  C  CG    . LYS B 1 597 ? 142.703 96.124  122.944 1.00 73.83  ? 589 LYS B CG    1 
ATOM   8601  C  CD    . LYS B 1 597 ? 142.555 94.740  122.332 1.00 71.92  ? 589 LYS B CD    1 
ATOM   8602  C  CE    . LYS B 1 597 ? 143.106 94.693  120.919 1.00 79.16  ? 589 LYS B CE    1 
ATOM   8603  N  NZ    . LYS B 1 597 ? 142.917 93.351  120.302 1.00 81.59  ? 589 LYS B NZ    1 
ATOM   8604  N  N     . LYS B 1 598 ? 140.587 98.761  126.473 1.00 69.22  ? 590 LYS B N     1 
ATOM   8605  C  CA    . LYS B 1 598 ? 139.702 98.965  127.609 1.00 67.67  ? 590 LYS B CA    1 
ATOM   8606  C  C     . LYS B 1 598 ? 138.437 99.676  127.156 1.00 66.32  ? 590 LYS B C     1 
ATOM   8607  O  O     . LYS B 1 598 ? 138.491 100.615 126.357 1.00 66.86  ? 590 LYS B O     1 
ATOM   8608  C  CB    . LYS B 1 598 ? 140.388 99.776  128.714 1.00 68.04  ? 590 LYS B CB    1 
ATOM   8609  C  CG    . LYS B 1 598 ? 141.568 99.071  129.357 1.00 70.71  ? 590 LYS B CG    1 
ATOM   8610  C  CD    . LYS B 1 598 ? 142.197 99.929  130.438 1.00 75.53  ? 590 LYS B CD    1 
ATOM   8611  C  CE    . LYS B 1 598 ? 143.385 99.229  131.074 1.00 81.97  ? 590 LYS B CE    1 
ATOM   8612  N  NZ    . LYS B 1 598 ? 144.030 100.069 132.120 1.00 83.28  ? 590 LYS B NZ    1 
ATOM   8613  N  N     . ALA B 1 599 ? 137.300 99.220  127.671 1.00 60.94  ? 591 ALA B N     1 
ATOM   8614  C  CA    . ALA B 1 599 ? 136.003 99.827  127.404 1.00 54.49  ? 591 ALA B CA    1 
ATOM   8615  C  C     . ALA B 1 599 ? 135.488 100.442 128.697 1.00 55.95  ? 591 ALA B C     1 
ATOM   8616  O  O     . ALA B 1 599 ? 135.369 99.746  129.711 1.00 57.23  ? 591 ALA B O     1 
ATOM   8617  C  CB    . ALA B 1 599 ? 135.015 98.793  126.866 1.00 49.99  ? 591 ALA B CB    1 
ATOM   8618  N  N     . MET B 1 600 ? 135.182 101.736 128.664 1.00 55.61  ? 592 MET B N     1 
ATOM   8619  C  CA    . MET B 1 600 ? 134.733 102.448 129.857 1.00 53.71  ? 592 MET B CA    1 
ATOM   8620  C  C     . MET B 1 600 ? 133.215 102.335 129.955 1.00 54.10  ? 592 MET B C     1 
ATOM   8621  O  O     . MET B 1 600 ? 132.494 102.859 129.104 1.00 55.90  ? 592 MET B O     1 
ATOM   8622  C  CB    . MET B 1 600 ? 135.179 103.906 129.812 1.00 55.86  ? 592 MET B CB    1 
ATOM   8623  C  CG    . MET B 1 600 ? 136.673 104.081 129.622 1.00 57.78  ? 592 MET B CG    1 
ATOM   8624  S  SD    . MET B 1 600 ? 137.204 105.786 129.842 1.00 66.63  ? 592 MET B SD    1 
ATOM   8625  C  CE    . MET B 1 600 ? 136.051 106.630 128.769 1.00 55.33  ? 592 MET B CE    1 
ATOM   8626  N  N     . ILE B 1 601 ? 132.732 101.658 130.991 1.00 50.67  ? 593 ILE B N     1 
ATOM   8627  C  CA    . ILE B 1 601 ? 131.307 101.388 131.152 1.00 48.46  ? 593 ILE B CA    1 
ATOM   8628  C  C     . ILE B 1 601 ? 130.649 102.560 131.866 1.00 50.74  ? 593 ILE B C     1 
ATOM   8629  O  O     . ILE B 1 601 ? 131.153 103.041 132.888 1.00 53.50  ? 593 ILE B O     1 
ATOM   8630  C  CB    . ILE B 1 601 ? 131.081 100.081 131.927 1.00 45.60  ? 593 ILE B CB    1 
ATOM   8631  C  CG1   . ILE B 1 601 ? 131.524 98.881  131.093 1.00 47.45  ? 593 ILE B CG1   1 
ATOM   8632  C  CG2   . ILE B 1 601 ? 129.624 99.943  132.333 1.00 43.80  ? 593 ILE B CG2   1 
ATOM   8633  C  CD1   . ILE B 1 601 ? 131.341 97.560  131.799 1.00 52.60  ? 593 ILE B CD1   1 
ATOM   8634  N  N     . VAL B 1 602 ? 129.526 103.021 131.329 1.00 49.90  ? 594 VAL B N     1 
ATOM   8635  C  CA    . VAL B 1 602 ? 128.711 104.057 131.956 1.00 51.94  ? 594 VAL B CA    1 
ATOM   8636  C  C     . VAL B 1 602 ? 127.499 103.379 132.586 1.00 57.11  ? 594 VAL B C     1 
ATOM   8637  O  O     . VAL B 1 602 ? 126.732 102.722 131.865 1.00 55.98  ? 594 VAL B O     1 
ATOM   8638  C  CB    . VAL B 1 602 ? 128.279 105.128 130.945 1.00 46.88  ? 594 VAL B CB    1 
ATOM   8639  C  CG1   . VAL B 1 602 ? 127.289 106.085 131.581 1.00 48.71  ? 594 VAL B CG1   1 
ATOM   8640  C  CG2   . VAL B 1 602 ? 129.491 105.885 130.429 1.00 45.33  ? 594 VAL B CG2   1 
ATOM   8641  N  N     . PRO B 1 603 ? 127.303 103.484 133.900 1.00 56.09  ? 595 PRO B N     1 
ATOM   8642  C  CA    . PRO B 1 603 ? 126.160 102.815 134.535 1.00 53.30  ? 595 PRO B CA    1 
ATOM   8643  C  C     . PRO B 1 603 ? 124.832 103.303 133.973 1.00 54.76  ? 595 PRO B C     1 
ATOM   8644  O  O     . PRO B 1 603 ? 124.660 104.484 133.664 1.00 51.56  ? 595 PRO B O     1 
ATOM   8645  C  CB    . PRO B 1 603 ? 126.314 103.185 136.014 1.00 54.12  ? 595 PRO B CB    1 
ATOM   8646  C  CG    . PRO B 1 603 ? 127.767 103.471 136.176 1.00 51.01  ? 595 PRO B CG    1 
ATOM   8647  C  CD    . PRO B 1 603 ? 128.208 104.093 134.887 1.00 51.03  ? 595 PRO B CD    1 
ATOM   8648  N  N     . ALA B 1 604 ? 123.887 102.376 133.849 1.00 57.35  ? 596 ALA B N     1 
ATOM   8649  C  CA    . ALA B 1 604 ? 122.593 102.638 133.237 1.00 55.74  ? 596 ALA B CA    1 
ATOM   8650  C  C     . ALA B 1 604 ? 121.488 102.532 134.278 1.00 61.56  ? 596 ALA B C     1 
ATOM   8651  O  O     . ALA B 1 604 ? 121.414 101.543 135.014 1.00 64.83  ? 596 ALA B O     1 
ATOM   8652  C  CB    . ALA B 1 604 ? 122.324 101.663 132.089 1.00 54.05  ? 596 ALA B CB    1 
ATOM   8653  N  N     . PHE B 1 605 ? 120.631 103.546 134.325 1.00 61.55  ? 597 PHE B N     1 
ATOM   8654  C  CA    . PHE B 1 605 ? 119.476 103.575 135.206 1.00 61.18  ? 597 PHE B CA    1 
ATOM   8655  C  C     . PHE B 1 605 ? 118.221 103.814 134.380 1.00 63.05  ? 597 PHE B C     1 
ATOM   8656  O  O     . PHE B 1 605 ? 118.283 104.277 133.239 1.00 65.41  ? 597 PHE B O     1 
ATOM   8657  C  CB    . PHE B 1 605 ? 119.618 104.663 136.276 1.00 58.63  ? 597 PHE B CB    1 
ATOM   8658  C  CG    . PHE B 1 605 ? 120.831 104.500 137.141 1.00 60.88  ? 597 PHE B CG    1 
ATOM   8659  C  CD1   . PHE B 1 605 ? 120.825 103.611 138.201 1.00 64.63  ? 597 PHE B CD1   1 
ATOM   8660  C  CD2   . PHE B 1 605 ? 121.977 105.231 136.893 1.00 58.21  ? 597 PHE B CD2   1 
ATOM   8661  C  CE1   . PHE B 1 605 ? 121.937 103.457 138.997 1.00 64.13  ? 597 PHE B CE1   1 
ATOM   8662  C  CE2   . PHE B 1 605 ? 123.093 105.079 137.686 1.00 57.59  ? 597 PHE B CE2   1 
ATOM   8663  C  CZ    . PHE B 1 605 ? 123.071 104.191 138.739 1.00 63.23  ? 597 PHE B CZ    1 
ATOM   8664  N  N     . GLU B 1 606 ? 117.073 103.486 134.965 1.00 68.01  ? 598 GLU B N     1 
ATOM   8665  C  CA    . GLU B 1 606 ? 115.797 103.646 134.289 1.00 67.85  ? 598 GLU B CA    1 
ATOM   8666  C  C     . GLU B 1 606 ? 114.789 104.294 135.225 1.00 72.54  ? 598 GLU B C     1 
ATOM   8667  O  O     . GLU B 1 606 ? 114.897 104.205 136.450 1.00 78.01  ? 598 GLU B O     1 
ATOM   8668  C  CB    . GLU B 1 606 ? 115.253 102.305 133.783 1.00 69.41  ? 598 GLU B CB    1 
ATOM   8669  C  CG    . GLU B 1 606 ? 114.943 101.308 134.879 1.00 78.18  ? 598 GLU B CG    1 
ATOM   8670  C  CD    . GLU B 1 606 ? 114.361 100.020 134.338 1.00 83.93  ? 598 GLU B CD    1 
ATOM   8671  O  OE1   . GLU B 1 606 ? 114.148 99.933  133.110 1.00 81.11  ? 598 GLU B OE1   1 
ATOM   8672  O  OE2   . GLU B 1 606 ? 114.119 99.093  135.139 1.00 88.46  ? 598 GLU B OE2   1 
ATOM   8673  N  N     . THR B 1 607 ? 113.805 104.958 134.624 1.00 72.16  ? 599 THR B N     1 
ATOM   8674  C  CA    . THR B 1 607 ? 112.722 105.591 135.356 1.00 71.92  ? 599 THR B CA    1 
ATOM   8675  C  C     . THR B 1 607 ? 111.416 105.310 134.632 1.00 75.54  ? 599 THR B C     1 
ATOM   8676  O  O     . THR B 1 607 ? 111.400 104.965 133.449 1.00 78.06  ? 599 THR B O     1 
ATOM   8677  C  CB    . THR B 1 607 ? 112.933 107.103 135.500 1.00 70.91  ? 599 THR B CB    1 
ATOM   8678  O  OG1   . THR B 1 607 ? 111.858 107.666 136.261 1.00 79.50  ? 599 THR B OG1   1 
ATOM   8679  C  CG2   . THR B 1 607 ? 112.981 107.769 134.136 1.00 69.46  ? 599 THR B CG2   1 
ATOM   8680  N  N     . LEU B 1 608 ? 110.313 105.449 135.362 1.00 78.66  ? 600 LEU B N     1 
ATOM   8681  C  CA    . LEU B 1 608 ? 108.988 105.243 134.798 1.00 75.96  ? 600 LEU B CA    1 
ATOM   8682  C  C     . LEU B 1 608 ? 108.168 106.523 134.730 1.00 75.98  ? 600 LEU B C     1 
ATOM   8683  O  O     . LEU B 1 608 ? 107.053 106.500 134.201 1.00 78.51  ? 600 LEU B O     1 
ATOM   8684  C  CB    . LEU B 1 608 ? 108.232 104.183 135.605 1.00 78.39  ? 600 LEU B CB    1 
ATOM   8685  C  CG    . LEU B 1 608 ? 108.939 102.831 135.720 1.00 81.57  ? 600 LEU B CG    1 
ATOM   8686  C  CD1   . LEU B 1 608 ? 108.087 101.837 136.493 1.00 79.53  ? 600 LEU B CD1   1 
ATOM   8687  C  CD2   . LEU B 1 608 ? 109.286 102.289 134.343 1.00 80.39  ? 600 LEU B CD2   1 
ATOM   8688  N  N     . ARG B 1 609 ? 108.690 107.636 135.236 1.00 78.91  ? 601 ARG B N     1 
ATOM   8689  C  CA    . ARG B 1 609 ? 107.975 108.905 135.244 1.00 83.47  ? 601 ARG B CA    1 
ATOM   8690  C  C     . ARG B 1 609 ? 108.547 109.806 134.157 1.00 80.17  ? 601 ARG B C     1 
ATOM   8691  O  O     . ARG B 1 609 ? 109.754 110.066 134.133 1.00 81.18  ? 601 ARG B O     1 
ATOM   8692  C  CB    . ARG B 1 609 ? 108.080 109.577 136.612 1.00 84.27  ? 601 ARG B CB    1 
ATOM   8693  C  CG    . ARG B 1 609 ? 107.544 108.730 137.754 1.00 85.35  ? 601 ARG B CG    1 
ATOM   8694  C  CD    . ARG B 1 609 ? 107.791 109.389 139.100 1.00 92.43  ? 601 ARG B CD    1 
ATOM   8695  N  NE    . ARG B 1 609 ? 107.363 108.539 140.204 1.00 98.55  ? 601 ARG B NE    1 
ATOM   8696  C  CZ    . ARG B 1 609 ? 107.522 108.840 141.486 1.00 100.25 ? 601 ARG B CZ    1 
ATOM   8697  N  NH1   . ARG B 1 609 ? 108.098 109.969 141.865 1.00 101.31 ? 601 ARG B NH1   1 
ATOM   8698  N  NH2   . ARG B 1 609 ? 107.092 107.986 142.410 1.00 101.65 ? 601 ARG B NH2   1 
ATOM   8699  N  N     . TYR B 1 610 ? 107.677 110.276 133.261 1.00 79.33  ? 602 TYR B N     1 
ATOM   8700  C  CA    . TYR B 1 610 ? 108.126 111.161 132.191 1.00 83.07  ? 602 TYR B CA    1 
ATOM   8701  C  C     . TYR B 1 610 ? 108.649 112.479 132.745 1.00 84.39  ? 602 TYR B C     1 
ATOM   8702  O  O     . TYR B 1 610 ? 109.692 112.975 132.306 1.00 82.87  ? 602 TYR B O     1 
ATOM   8703  C  CB    . TYR B 1 610 ? 106.988 111.404 131.202 1.00 86.69  ? 602 TYR B CB    1 
ATOM   8704  C  CG    . TYR B 1 610 ? 106.627 110.185 130.387 1.00 91.89  ? 602 TYR B CG    1 
ATOM   8705  C  CD1   . TYR B 1 610 ? 105.766 109.219 130.890 1.00 89.80  ? 602 TYR B CD1   1 
ATOM   8706  C  CD2   . TYR B 1 610 ? 107.151 109.998 129.115 1.00 97.18  ? 602 TYR B CD2   1 
ATOM   8707  C  CE1   . TYR B 1 610 ? 105.436 108.102 130.149 1.00 91.82  ? 602 TYR B CE1   1 
ATOM   8708  C  CE2   . TYR B 1 610 ? 106.826 108.885 128.366 1.00 97.33  ? 602 TYR B CE2   1 
ATOM   8709  C  CZ    . TYR B 1 610 ? 105.969 107.941 128.888 1.00 95.84  ? 602 TYR B CZ    1 
ATOM   8710  O  OH    . TYR B 1 610 ? 105.643 106.834 128.144 1.00 89.78  ? 602 TYR B OH    1 
ATOM   8711  N  N     . ARG B 1 611 ? 107.943 113.059 133.712 1.00 89.05  ? 603 ARG B N     1 
ATOM   8712  C  CA    . ARG B 1 611 ? 108.406 114.275 134.371 1.00 90.81  ? 603 ARG B CA    1 
ATOM   8713  C  C     . ARG B 1 611 ? 109.467 113.893 135.392 1.00 87.26  ? 603 ARG B C     1 
ATOM   8714  O  O     . ARG B 1 611 ? 109.163 113.266 136.412 1.00 88.43  ? 603 ARG B O     1 
ATOM   8715  C  CB    . ARG B 1 611 ? 107.244 115.012 135.030 1.00 94.48  ? 603 ARG B CB    1 
ATOM   8716  C  CG    . ARG B 1 611 ? 106.381 115.803 134.062 1.00 98.90  ? 603 ARG B CG    1 
ATOM   8717  C  CD    . ARG B 1 611 ? 105.427 116.722 134.806 1.00 107.77 ? 603 ARG B CD    1 
ATOM   8718  N  NE    . ARG B 1 611 ? 104.761 117.659 133.909 1.00 115.31 ? 603 ARG B NE    1 
ATOM   8719  C  CZ    . ARG B 1 611 ? 103.941 118.622 134.306 1.00 119.83 ? 603 ARG B CZ    1 
ATOM   8720  N  NH1   . ARG B 1 611 ? 103.657 118.804 135.585 1.00 123.48 ? 603 ARG B NH1   1 
ATOM   8721  N  NH2   . ARG B 1 611 ? 103.394 119.424 133.397 1.00 114.80 ? 603 ARG B NH2   1 
ATOM   8722  N  N     . LEU B 1 612 ? 110.714 114.264 135.119 1.00 85.17  ? 604 LEU B N     1 
ATOM   8723  C  CA    . LEU B 1 612 ? 111.840 113.891 135.961 1.00 83.63  ? 604 LEU B CA    1 
ATOM   8724  C  C     . LEU B 1 612 ? 112.712 115.109 136.214 1.00 83.05  ? 604 LEU B C     1 
ATOM   8725  O  O     . LEU B 1 612 ? 113.058 115.834 135.276 1.00 83.88  ? 604 LEU B O     1 
ATOM   8726  C  CB    . LEU B 1 612 ? 112.664 112.778 135.310 1.00 80.71  ? 604 LEU B CB    1 
ATOM   8727  C  CG    . LEU B 1 612 ? 113.811 112.218 136.149 1.00 80.32  ? 604 LEU B CG    1 
ATOM   8728  C  CD1   . LEU B 1 612 ? 113.262 111.596 137.418 1.00 85.94  ? 604 LEU B CD1   1 
ATOM   8729  C  CD2   . LEU B 1 612 ? 114.614 111.203 135.354 1.00 72.75  ? 604 LEU B CD2   1 
ATOM   8730  N  N     . SER B 1 613 ? 113.064 115.331 137.477 1.00 79.68  ? 605 SER B N     1 
ATOM   8731  C  CA    . SER B 1 613 ? 114.039 116.354 137.845 1.00 79.31  ? 605 SER B CA    1 
ATOM   8732  C  C     . SER B 1 613 ? 115.416 115.712 137.756 1.00 78.97  ? 605 SER B C     1 
ATOM   8733  O  O     . SER B 1 613 ? 115.817 114.949 138.638 1.00 80.41  ? 605 SER B O     1 
ATOM   8734  C  CB    . SER B 1 613 ? 113.759 116.899 139.240 1.00 80.71  ? 605 SER B CB    1 
ATOM   8735  O  OG    . SER B 1 613 ? 114.731 117.860 139.613 1.00 77.73  ? 605 SER B OG    1 
ATOM   8736  N  N     . PHE B 1 614 ? 116.139 116.016 136.687 1.00 74.46  ? 606 PHE B N     1 
ATOM   8737  C  CA    . PHE B 1 614 ? 117.403 115.339 136.432 1.00 72.60  ? 606 PHE B CA    1 
ATOM   8738  C  C     . PHE B 1 614 ? 118.442 115.761 137.466 1.00 73.04  ? 606 PHE B C     1 
ATOM   8739  O  O     . PHE B 1 614 ? 118.681 116.961 137.644 1.00 74.54  ? 606 PHE B O     1 
ATOM   8740  C  CB    . PHE B 1 614 ? 117.899 115.649 135.023 1.00 71.33  ? 606 PHE B CB    1 
ATOM   8741  C  CG    . PHE B 1 614 ? 118.676 114.528 134.398 1.00 65.89  ? 606 PHE B CG    1 
ATOM   8742  C  CD1   . PHE B 1 614 ? 118.020 113.484 133.769 1.00 64.09  ? 606 PHE B CD1   1 
ATOM   8743  C  CD2   . PHE B 1 614 ? 120.058 114.515 134.444 1.00 62.37  ? 606 PHE B CD2   1 
ATOM   8744  C  CE1   . PHE B 1 614 ? 118.728 112.450 133.195 1.00 60.66  ? 606 PHE B CE1   1 
ATOM   8745  C  CE2   . PHE B 1 614 ? 120.771 113.483 133.873 1.00 62.47  ? 606 PHE B CE2   1 
ATOM   8746  C  CZ    . PHE B 1 614 ? 120.105 112.449 133.248 1.00 60.36  ? 606 PHE B CZ    1 
ATOM   8747  N  N     . PRO B 1 615 ? 119.069 114.816 138.165 1.00 69.45  ? 607 PRO B N     1 
ATOM   8748  C  CA    . PRO B 1 615 ? 120.048 115.185 139.192 1.00 70.16  ? 607 PRO B CA    1 
ATOM   8749  C  C     . PRO B 1 615 ? 121.261 115.877 138.593 1.00 71.85  ? 607 PRO B C     1 
ATOM   8750  O  O     . PRO B 1 615 ? 121.664 115.608 137.460 1.00 74.82  ? 607 PRO B O     1 
ATOM   8751  C  CB    . PRO B 1 615 ? 120.426 113.839 139.818 1.00 70.69  ? 607 PRO B CB    1 
ATOM   8752  C  CG    . PRO B 1 615 ? 120.123 112.834 138.757 1.00 65.65  ? 607 PRO B CG    1 
ATOM   8753  C  CD    . PRO B 1 615 ? 118.918 113.357 138.040 1.00 64.36  ? 607 PRO B CD    1 
ATOM   8754  N  N     . LYS B 1 616 ? 121.841 116.784 139.374 1.00 72.00  ? 608 LYS B N     1 
ATOM   8755  C  CA    . LYS B 1 616 ? 123.045 117.502 138.983 1.00 74.71  ? 608 LYS B CA    1 
ATOM   8756  C  C     . LYS B 1 616 ? 124.298 116.949 139.649 1.00 73.05  ? 608 LYS B C     1 
ATOM   8757  O  O     . LYS B 1 616 ? 125.378 117.528 139.493 1.00 73.97  ? 608 LYS B O     1 
ATOM   8758  C  CB    . LYS B 1 616 ? 122.897 118.990 139.303 1.00 75.18  ? 608 LYS B CB    1 
ATOM   8759  C  CG    . LYS B 1 616 ? 121.729 119.658 138.599 1.00 74.92  ? 608 LYS B CG    1 
ATOM   8760  C  CD    . LYS B 1 616 ? 121.661 121.139 138.930 1.00 78.54  ? 608 LYS B CD    1 
ATOM   8761  C  CE    . LYS B 1 616 ? 120.513 121.816 138.199 1.00 81.50  ? 608 LYS B CE    1 
ATOM   8762  N  NZ    . LYS B 1 616 ? 120.458 123.276 138.485 1.00 85.18  ? 608 LYS B NZ    1 
ATOM   8763  N  N     . SER B 1 617 ? 124.180 115.848 140.386 1.00 70.17  ? 609 SER B N     1 
ATOM   8764  C  CA    . SER B 1 617 ? 125.320 115.254 141.069 1.00 72.91  ? 609 SER B CA    1 
ATOM   8765  C  C     . SER B 1 617 ? 125.004 113.793 141.356 1.00 73.00  ? 609 SER B C     1 
ATOM   8766  O  O     . SER B 1 617 ? 123.855 113.355 141.267 1.00 74.13  ? 609 SER B O     1 
ATOM   8767  C  CB    . SER B 1 617 ? 125.657 116.010 142.357 1.00 76.97  ? 609 SER B CB    1 
ATOM   8768  O  OG    . SER B 1 617 ? 124.551 116.027 143.243 1.00 81.64  ? 609 SER B OG    1 
ATOM   8769  N  N     . LYS B 1 618 ? 126.050 113.039 141.699 1.00 69.04  ? 610 LYS B N     1 
ATOM   8770  C  CA    . LYS B 1 618 ? 125.867 111.628 142.022 1.00 69.73  ? 610 LYS B CA    1 
ATOM   8771  C  C     . LYS B 1 618 ? 125.103 111.444 143.327 1.00 79.02  ? 610 LYS B C     1 
ATOM   8772  O  O     . LYS B 1 618 ? 124.333 110.485 143.462 1.00 80.87  ? 610 LYS B O     1 
ATOM   8773  C  CB    . LYS B 1 618 ? 127.222 110.925 142.095 1.00 66.35  ? 610 LYS B CB    1 
ATOM   8774  C  CG    . LYS B 1 618 ? 127.128 109.423 142.310 1.00 65.64  ? 610 LYS B CG    1 
ATOM   8775  C  CD    . LYS B 1 618 ? 128.502 108.777 142.368 1.00 62.91  ? 610 LYS B CD    1 
ATOM   8776  C  CE    . LYS B 1 618 ? 128.389 107.274 142.562 1.00 63.09  ? 610 LYS B CE    1 
ATOM   8777  N  NZ    . LYS B 1 618 ? 129.723 106.620 142.637 1.00 64.70  ? 610 LYS B NZ    1 
ATOM   8778  N  N     . ALA B 1 619 ? 125.304 112.341 144.296 1.00 77.39  ? 611 ALA B N     1 
ATOM   8779  C  CA    . ALA B 1 619 ? 124.611 112.221 145.575 1.00 75.85  ? 611 ALA B CA    1 
ATOM   8780  C  C     . ALA B 1 619 ? 123.103 112.338 145.399 1.00 75.97  ? 611 ALA B C     1 
ATOM   8781  O  O     . ALA B 1 619 ? 122.336 111.594 146.024 1.00 78.18  ? 611 ALA B O     1 
ATOM   8782  C  CB    . ALA B 1 619 ? 125.122 113.280 146.550 1.00 79.27  ? 611 ALA B CB    1 
ATOM   8783  N  N     . GLU B 1 620 ? 122.657 113.268 144.553 1.00 75.88  ? 612 GLU B N     1 
ATOM   8784  C  CA    . GLU B 1 620 ? 121.228 113.396 144.289 1.00 76.24  ? 612 GLU B CA    1 
ATOM   8785  C  C     . GLU B 1 620 ? 120.684 112.150 143.602 1.00 76.07  ? 612 GLU B C     1 
ATOM   8786  O  O     . GLU B 1 620 ? 119.561 111.718 143.882 1.00 76.91  ? 612 GLU B O     1 
ATOM   8787  C  CB    . GLU B 1 620 ? 120.959 114.642 143.446 1.00 74.75  ? 612 GLU B CB    1 
ATOM   8788  C  CG    . GLU B 1 620 ? 119.485 114.918 143.210 1.00 80.96  ? 612 GLU B CG    1 
ATOM   8789  C  CD    . GLU B 1 620 ? 119.246 116.227 142.487 1.00 92.63  ? 612 GLU B CD    1 
ATOM   8790  O  OE1   . GLU B 1 620 ? 120.223 116.974 142.270 1.00 94.69  ? 612 GLU B OE1   1 
ATOM   8791  O  OE2   . GLU B 1 620 ? 118.082 116.510 142.136 1.00 92.47  ? 612 GLU B OE2   1 
ATOM   8792  N  N     . LEU B 1 621 ? 121.468 111.559 142.696 1.00 73.02  ? 613 LEU B N     1 
ATOM   8793  C  CA    . LEU B 1 621 ? 121.051 110.315 142.056 1.00 72.65  ? 613 LEU B CA    1 
ATOM   8794  C  C     . LEU B 1 621 ? 120.901 109.195 143.076 1.00 76.16  ? 613 LEU B C     1 
ATOM   8795  O  O     . LEU B 1 621 ? 119.942 108.416 143.018 1.00 79.28  ? 613 LEU B O     1 
ATOM   8796  C  CB    . LEU B 1 621 ? 122.055 109.920 140.975 1.00 72.98  ? 613 LEU B CB    1 
ATOM   8797  C  CG    . LEU B 1 621 ? 121.947 108.489 140.443 1.00 68.24  ? 613 LEU B CG    1 
ATOM   8798  C  CD1   . LEU B 1 621 ? 120.630 108.273 139.720 1.00 67.44  ? 613 LEU B CD1   1 
ATOM   8799  C  CD2   . LEU B 1 621 ? 123.115 108.174 139.533 1.00 61.03  ? 613 LEU B CD2   1 
ATOM   8800  N  N     . LEU B 1 622 ? 121.843 109.094 144.015 1.00 74.42  ? 614 LEU B N     1 
ATOM   8801  C  CA    . LEU B 1 622 ? 121.734 108.085 145.064 1.00 73.48  ? 614 LEU B CA    1 
ATOM   8802  C  C     . LEU B 1 622 ? 120.506 108.327 145.931 1.00 79.43  ? 614 LEU B C     1 
ATOM   8803  O  O     . LEU B 1 622 ? 119.805 107.380 146.309 1.00 82.72  ? 614 LEU B O     1 
ATOM   8804  C  CB    . LEU B 1 622 ? 123.001 108.077 145.917 1.00 74.89  ? 614 LEU B CB    1 
ATOM   8805  C  CG    . LEU B 1 622 ? 124.293 107.699 145.194 1.00 76.91  ? 614 LEU B CG    1 
ATOM   8806  C  CD1   . LEU B 1 622 ? 125.482 107.798 146.136 1.00 80.82  ? 614 LEU B CD1   1 
ATOM   8807  C  CD2   . LEU B 1 622 ? 124.184 106.301 144.609 1.00 75.02  ? 614 LEU B CD2   1 
ATOM   8808  N  N     . SER B 1 623 ? 120.231 109.591 146.257 1.00 79.39  ? 615 SER B N     1 
ATOM   8809  C  CA    . SER B 1 623 ? 119.041 109.912 147.038 1.00 77.93  ? 615 SER B CA    1 
ATOM   8810  C  C     . SER B 1 623 ? 117.772 109.511 146.297 1.00 81.80  ? 615 SER B C     1 
ATOM   8811  O  O     . SER B 1 623 ? 116.841 108.961 146.897 1.00 83.48  ? 615 SER B O     1 
ATOM   8812  C  CB    . SER B 1 623 ? 119.019 111.403 147.373 1.00 77.00  ? 615 SER B CB    1 
ATOM   8813  O  OG    . SER B 1 623 ? 117.859 111.741 148.112 1.00 80.00  ? 615 SER B OG    1 
ATOM   8814  N  N     . MET B 1 624 ? 117.717 109.781 144.992 1.00 82.30  ? 616 MET B N     1 
ATOM   8815  C  CA    . MET B 1 624 ? 116.552 109.395 144.201 1.00 81.56  ? 616 MET B CA    1 
ATOM   8816  C  C     . MET B 1 624 ? 116.415 107.880 144.120 1.00 79.59  ? 616 MET B C     1 
ATOM   8817  O  O     . MET B 1 624 ? 115.297 107.353 144.103 1.00 82.04  ? 616 MET B O     1 
ATOM   8818  C  CB    . MET B 1 624 ? 116.640 110.005 142.803 1.00 76.28  ? 616 MET B CB    1 
ATOM   8819  C  CG    . MET B 1 624 ? 116.623 111.523 142.794 1.00 77.60  ? 616 MET B CG    1 
ATOM   8820  S  SD    . MET B 1 624 ? 116.548 112.212 141.134 1.00 78.32  ? 616 MET B SD    1 
ATOM   8821  C  CE    . MET B 1 624 ? 114.954 111.599 140.603 1.00 73.85  ? 616 MET B CE    1 
ATOM   8822  N  N     . LEU B 1 625 ? 117.541 107.166 144.055 1.00 79.07  ? 617 LEU B N     1 
ATOM   8823  C  CA    . LEU B 1 625 ? 117.496 105.708 144.104 1.00 82.09  ? 617 LEU B CA    1 
ATOM   8824  C  C     . LEU B 1 625 ? 116.937 105.221 145.433 1.00 88.74  ? 617 LEU B C     1 
ATOM   8825  O  O     . LEU B 1 625 ? 116.169 104.253 145.475 1.00 92.69  ? 617 LEU B O     1 
ATOM   8826  C  CB    . LEU B 1 625 ? 118.890 105.127 143.872 1.00 81.80  ? 617 LEU B CB    1 
ATOM   8827  C  CG    . LEU B 1 625 ? 119.390 105.037 142.431 1.00 79.76  ? 617 LEU B CG    1 
ATOM   8828  C  CD1   . LEU B 1 625 ? 120.825 104.547 142.409 1.00 77.00  ? 617 LEU B CD1   1 
ATOM   8829  C  CD2   . LEU B 1 625 ? 118.498 104.117 141.618 1.00 78.07  ? 617 LEU B CD2   1 
ATOM   8830  N  N     . ASP B 1 626 ? 117.322 105.875 146.532 1.00 88.89  ? 618 ASP B N     1 
ATOM   8831  C  CA    . ASP B 1 626 ? 116.835 105.468 147.846 1.00 88.52  ? 618 ASP B CA    1 
ATOM   8832  C  C     . ASP B 1 626 ? 115.336 105.694 147.992 1.00 90.97  ? 618 ASP B C     1 
ATOM   8833  O  O     . ASP B 1 626 ? 114.657 104.914 148.670 1.00 92.97  ? 618 ASP B O     1 
ATOM   8834  C  CB    . ASP B 1 626 ? 117.590 106.220 148.942 1.00 90.82  ? 618 ASP B CB    1 
ATOM   8835  C  CG    . ASP B 1 626 ? 119.075 105.920 148.938 1.00 90.62  ? 618 ASP B CG    1 
ATOM   8836  O  OD1   . ASP B 1 626 ? 119.453 104.796 148.547 1.00 90.40  ? 618 ASP B OD1   1 
ATOM   8837  O  OD2   . ASP B 1 626 ? 119.863 106.808 149.325 1.00 90.26  ? 618 ASP B OD2   1 
ATOM   8838  N  N     . MET B 1 627 ? 114.801 106.742 147.367 1.00 88.96  ? 619 MET B N     1 
ATOM   8839  C  CA    . MET B 1 627 ? 113.384 107.061 147.481 1.00 88.39  ? 619 MET B CA    1 
ATOM   8840  C  C     . MET B 1 627 ? 112.511 106.251 146.532 1.00 89.24  ? 619 MET B C     1 
ATOM   8841  O  O     . MET B 1 627 ? 111.284 106.389 146.579 1.00 91.41  ? 619 MET B O     1 
ATOM   8842  C  CB    . MET B 1 627 ? 113.160 108.555 147.234 1.00 91.56  ? 619 MET B CB    1 
ATOM   8843  C  CG    . MET B 1 627 ? 113.878 109.460 148.220 1.00 95.02  ? 619 MET B CG    1 
ATOM   8844  S  SD    . MET B 1 627 ? 113.535 111.208 147.940 1.00 120.94 ? 619 MET B SD    1 
ATOM   8845  C  CE    . MET B 1 627 ? 114.091 111.398 146.248 1.00 93.29  ? 619 MET B CE    1 
ATOM   8846  N  N     . GLY B 1 628 ? 113.103 105.420 145.678 1.00 88.35  ? 620 GLY B N     1 
ATOM   8847  C  CA    . GLY B 1 628 ? 112.335 104.610 144.756 1.00 87.05  ? 620 GLY B CA    1 
ATOM   8848  C  C     . GLY B 1 628 ? 111.908 105.305 143.485 1.00 89.75  ? 620 GLY B C     1 
ATOM   8849  O  O     . GLY B 1 628 ? 111.178 104.705 142.688 1.00 88.58  ? 620 GLY B O     1 
ATOM   8850  N  N     . THR B 1 629 ? 112.329 106.552 143.269 1.00 89.58  ? 621 THR B N     1 
ATOM   8851  C  CA    . THR B 1 629 ? 111.971 107.246 142.036 1.00 87.03  ? 621 THR B CA    1 
ATOM   8852  C  C     . THR B 1 629 ? 112.705 106.660 140.837 1.00 87.36  ? 621 THR B C     1 
ATOM   8853  O  O     . THR B 1 629 ? 112.122 106.511 139.757 1.00 86.98  ? 621 THR B O     1 
ATOM   8854  C  CB    . THR B 1 629 ? 112.269 108.738 142.167 1.00 87.18  ? 621 THR B CB    1 
ATOM   8855  O  OG1   . THR B 1 629 ? 113.649 108.921 142.508 1.00 86.14  ? 621 THR B OG1   1 
ATOM   8856  C  CG2   . THR B 1 629 ? 111.399 109.361 143.247 1.00 90.05  ? 621 THR B CG2   1 
ATOM   8857  N  N     . LEU B 1 630 ? 113.979 106.318 141.006 1.00 87.27  ? 622 LEU B N     1 
ATOM   8858  C  CA    . LEU B 1 630 ? 114.792 105.757 139.940 1.00 82.74  ? 622 LEU B CA    1 
ATOM   8859  C  C     . LEU B 1 630 ? 115.209 104.338 140.298 1.00 82.91  ? 622 LEU B C     1 
ATOM   8860  O  O     . LEU B 1 630 ? 115.229 103.947 141.468 1.00 85.06  ? 622 LEU B O     1 
ATOM   8861  C  CB    . LEU B 1 630 ? 116.040 106.608 139.671 1.00 78.87  ? 622 LEU B CB    1 
ATOM   8862  C  CG    . LEU B 1 630 ? 115.833 108.097 139.391 1.00 81.44  ? 622 LEU B CG    1 
ATOM   8863  C  CD1   . LEU B 1 630 ? 117.132 108.741 138.942 1.00 68.25  ? 622 LEU B CD1   1 
ATOM   8864  C  CD2   . LEU B 1 630 ? 114.746 108.309 138.357 1.00 80.76  ? 622 LEU B CD2   1 
ATOM   8865  N  N     . PHE B 1 631 ? 115.543 103.568 139.268 1.00 78.54  ? 623 PHE B N     1 
ATOM   8866  C  CA    . PHE B 1 631 ? 116.002 102.200 139.436 1.00 80.39  ? 623 PHE B CA    1 
ATOM   8867  C  C     . PHE B 1 631 ? 117.158 101.948 138.481 1.00 77.69  ? 623 PHE B C     1 
ATOM   8868  O  O     . PHE B 1 631 ? 117.350 102.675 137.504 1.00 77.95  ? 623 PHE B O     1 
ATOM   8869  C  CB    . PHE B 1 631 ? 114.882 101.185 139.172 1.00 83.25  ? 623 PHE B CB    1 
ATOM   8870  C  CG    . PHE B 1 631 ? 113.646 101.415 139.992 1.00 87.25  ? 623 PHE B CG    1 
ATOM   8871  C  CD1   . PHE B 1 631 ? 113.508 100.829 141.238 1.00 87.46  ? 623 PHE B CD1   1 
ATOM   8872  C  CD2   . PHE B 1 631 ? 112.618 102.208 139.511 1.00 88.29  ? 623 PHE B CD2   1 
ATOM   8873  C  CE1   . PHE B 1 631 ? 112.370 101.034 141.993 1.00 89.60  ? 623 PHE B CE1   1 
ATOM   8874  C  CE2   . PHE B 1 631 ? 111.477 102.418 140.262 1.00 89.52  ? 623 PHE B CE2   1 
ATOM   8875  C  CZ    . PHE B 1 631 ? 111.353 101.829 141.504 1.00 87.98  ? 623 PHE B CZ    1 
ATOM   8876  N  N     . THR B 1 632 ? 117.935 100.911 138.778 1.00 77.29  ? 624 THR B N     1 
ATOM   8877  C  CA    . THR B 1 632 ? 118.928 100.446 137.822 1.00 76.25  ? 624 THR B CA    1 
ATOM   8878  C  C     . THR B 1 632 ? 118.224 99.912  136.581 1.00 78.20  ? 624 THR B C     1 
ATOM   8879  O  O     . THR B 1 632 ? 117.085 99.444  136.642 1.00 83.31  ? 624 THR B O     1 
ATOM   8880  C  CB    . THR B 1 632 ? 119.808 99.361  138.440 1.00 75.98  ? 624 THR B CB    1 
ATOM   8881  O  OG1   . THR B 1 632 ? 118.999 98.235  138.801 1.00 80.80  ? 624 THR B OG1   1 
ATOM   8882  C  CG2   . THR B 1 632 ? 120.513 99.891  139.678 1.00 71.38  ? 624 THR B CG2   1 
ATOM   8883  N  N     . PHE B 1 633 ? 118.904 100.004 135.440 1.00 73.37  ? 625 PHE B N     1 
ATOM   8884  C  CA    . PHE B 1 633 ? 118.272 99.648  134.177 1.00 74.87  ? 625 PHE B CA    1 
ATOM   8885  C  C     . PHE B 1 633 ? 117.846 98.185  134.176 1.00 81.87  ? 625 PHE B C     1 
ATOM   8886  O  O     . PHE B 1 633 ? 118.612 97.301  134.571 1.00 86.65  ? 625 PHE B O     1 
ATOM   8887  C  CB    . PHE B 1 633 ? 119.218 99.928  133.011 1.00 68.11  ? 625 PHE B CB    1 
ATOM   8888  C  CG    . PHE B 1 633 ? 118.622 99.626  131.668 1.00 66.40  ? 625 PHE B CG    1 
ATOM   8889  C  CD1   . PHE B 1 633 ? 117.502 100.309 131.227 1.00 67.83  ? 625 PHE B CD1   1 
ATOM   8890  C  CD2   . PHE B 1 633 ? 119.178 98.661  130.848 1.00 68.11  ? 625 PHE B CD2   1 
ATOM   8891  C  CE1   . PHE B 1 633 ? 116.946 100.033 129.993 1.00 67.12  ? 625 PHE B CE1   1 
ATOM   8892  C  CE2   . PHE B 1 633 ? 118.628 98.383  129.611 1.00 71.30  ? 625 PHE B CE2   1 
ATOM   8893  C  CZ    . PHE B 1 633 ? 117.510 99.069  129.185 1.00 69.76  ? 625 PHE B CZ    1 
ATOM   8894  N  N     . ARG B 1 634 ? 116.611 97.941  133.733 1.00 81.24  ? 626 ARG B N     1 
ATOM   8895  C  CA    . ARG B 1 634 ? 116.026 96.600  133.681 1.00 84.37  ? 626 ARG B CA    1 
ATOM   8896  C  C     . ARG B 1 634 ? 116.028 95.932  135.055 1.00 90.98  ? 626 ARG B C     1 
ATOM   8897  O  O     . ARG B 1 634 ? 116.247 94.726  135.178 1.00 93.36  ? 626 ARG B O     1 
ATOM   8898  C  CB    . ARG B 1 634 ? 116.741 95.722  132.653 1.00 82.91  ? 626 ARG B CB    1 
ATOM   8899  C  CG    . ARG B 1 634 ? 116.516 96.122  131.208 1.00 85.01  ? 626 ARG B CG    1 
ATOM   8900  C  CD    . ARG B 1 634 ? 117.237 95.165  130.270 1.00 85.16  ? 626 ARG B CD    1 
ATOM   8901  N  NE    . ARG B 1 634 ? 117.116 95.558  128.871 1.00 83.51  ? 626 ARG B NE    1 
ATOM   8902  C  CZ    . ARG B 1 634 ? 117.639 94.883  127.857 1.00 87.37  ? 626 ARG B CZ    1 
ATOM   8903  N  NH1   . ARG B 1 634 ? 118.325 93.768  128.049 1.00 86.56  ? 626 ARG B NH1   1 
ATOM   8904  N  NH2   . ARG B 1 634 ? 117.469 95.337  126.618 1.00 85.77  ? 626 ARG B NH2   1 
ATOM   8905  N  N     . TYR B 1 635 ? 115.777 96.723  136.100 1.00 89.24  ? 627 TYR B N     1 
ATOM   8906  C  CA    . TYR B 1 635 ? 115.727 96.162  137.447 1.00 92.45  ? 627 TYR B CA    1 
ATOM   8907  C  C     . TYR B 1 635 ? 114.480 95.310  137.649 1.00 96.15  ? 627 TYR B C     1 
ATOM   8908  O  O     . TYR B 1 635 ? 114.526 94.286  138.339 1.00 94.00  ? 627 TYR B O     1 
ATOM   8909  C  CB    . TYR B 1 635 ? 115.783 97.282  138.486 1.00 93.41  ? 627 TYR B CB    1 
ATOM   8910  C  CG    . TYR B 1 635 ? 115.806 96.794  139.917 1.00 93.06  ? 627 TYR B CG    1 
ATOM   8911  C  CD1   . TYR B 1 635 ? 116.991 96.380  140.510 1.00 93.81  ? 627 TYR B CD1   1 
ATOM   8912  C  CD2   . TYR B 1 635 ? 114.644 96.751  140.676 1.00 91.80  ? 627 TYR B CD2   1 
ATOM   8913  C  CE1   . TYR B 1 635 ? 117.018 95.934  141.816 1.00 97.72  ? 627 TYR B CE1   1 
ATOM   8914  C  CE2   . TYR B 1 635 ? 114.661 96.306  141.983 1.00 97.23  ? 627 TYR B CE2   1 
ATOM   8915  C  CZ    . TYR B 1 635 ? 115.851 95.899  142.548 1.00 102.57 ? 627 TYR B CZ    1 
ATOM   8916  O  OH    . TYR B 1 635 ? 115.875 95.455  143.849 1.00 109.15 ? 627 TYR B OH    1 
ATOM   8917  N  N     . HIS B 1 636 ? 113.357 95.718  137.063 1.00 98.11  ? 628 HIS B N     1 
ATOM   8918  C  CA    . HIS B 1 636 ? 112.087 95.042  137.284 1.00 99.24  ? 628 HIS B CA    1 
ATOM   8919  C  C     . HIS B 1 636 ? 111.837 93.885  136.326 1.00 99.36  ? 628 HIS B C     1 
ATOM   8920  O  O     . HIS B 1 636 ? 110.883 93.129  136.535 1.00 102.59 ? 628 HIS B O     1 
ATOM   8921  C  CB    . HIS B 1 636 ? 110.933 96.045  137.173 1.00 97.36  ? 628 HIS B CB    1 
ATOM   8922  C  CG    . HIS B 1 636 ? 111.055 97.211  138.104 1.00 102.51 ? 628 HIS B CG    1 
ATOM   8923  N  ND1   . HIS B 1 636 ? 110.502 97.217  139.367 1.00 106.53 ? 628 HIS B ND1   1 
ATOM   8924  C  CD2   . HIS B 1 636 ? 111.666 98.410  137.956 1.00 99.15  ? 628 HIS B CD2   1 
ATOM   8925  C  CE1   . HIS B 1 636 ? 110.768 98.368  139.956 1.00 101.76 ? 628 HIS B CE1   1 
ATOM   8926  N  NE2   . HIS B 1 636 ? 111.473 99.111  139.122 1.00 101.98 ? 628 HIS B NE2   1 
ATOM   8927  N  N     . VAL B 1 637 ? 112.657 93.722  135.289 1.00 96.51  ? 629 VAL B N     1 
ATOM   8928  C  CA    . VAL B 1 637 ? 112.395 92.703  134.279 1.00 95.80  ? 629 VAL B CA    1 
ATOM   8929  C  C     . VAL B 1 637 ? 113.571 91.744  134.159 1.00 96.91  ? 629 VAL B C     1 
ATOM   8930  O  O     . VAL B 1 637 ? 113.430 90.539  134.394 1.00 100.07 ? 629 VAL B O     1 
ATOM   8931  C  CB    . VAL B 1 637 ? 112.083 93.345  132.914 1.00 100.19 ? 629 VAL B CB    1 
ATOM   8932  C  CG1   . VAL B 1 637 ? 111.741 92.271  131.892 1.00 101.27 ? 629 VAL B CG1   1 
ATOM   8933  C  CG2   . VAL B 1 637 ? 110.950 94.352  133.041 1.00 101.66 ? 629 VAL B CG2   1 
ATOM   8934  N  N     . TRP B 1 638 ? 114.741 92.269  133.788 1.00 95.20  ? 630 TRP B N     1 
ATOM   8935  C  CA    . TRP B 1 638 ? 115.903 91.439  133.455 1.00 97.75  ? 630 TRP B CA    1 
ATOM   8936  C  C     . TRP B 1 638 ? 117.149 92.095  134.049 1.00 93.31  ? 630 TRP B C     1 
ATOM   8937  O  O     . TRP B 1 638 ? 117.811 92.902  133.392 1.00 95.27  ? 630 TRP B O     1 
ATOM   8938  C  CB    . TRP B 1 638 ? 116.014 91.269  131.944 1.00 95.97  ? 630 TRP B CB    1 
ATOM   8939  C  CG    . TRP B 1 638 ? 117.083 90.326  131.497 1.00 93.46  ? 630 TRP B CG    1 
ATOM   8940  C  CD1   . TRP B 1 638 ? 118.379 90.635  131.210 1.00 91.92  ? 630 TRP B CD1   1 
ATOM   8941  C  CD2   . TRP B 1 638 ? 116.945 88.919  131.271 1.00 94.24  ? 630 TRP B CD2   1 
ATOM   8942  N  NE1   . TRP B 1 638 ? 119.060 89.507  130.824 1.00 94.16  ? 630 TRP B NE1   1 
ATOM   8943  C  CE2   . TRP B 1 638 ? 118.202 88.439  130.854 1.00 95.31  ? 630 TRP B CE2   1 
ATOM   8944  C  CE3   . TRP B 1 638 ? 115.883 88.018  131.384 1.00 93.52  ? 630 TRP B CE3   1 
ATOM   8945  C  CZ2   . TRP B 1 638 ? 118.425 87.099  130.549 1.00 94.65  ? 630 TRP B CZ2   1 
ATOM   8946  C  CZ3   . TRP B 1 638 ? 116.106 86.688  131.081 1.00 92.60  ? 630 TRP B CZ3   1 
ATOM   8947  C  CH2   . TRP B 1 638 ? 117.367 86.241  130.669 1.00 94.31  ? 630 TRP B CH2   1 
ATOM   8948  N  N     . THR B 1 639 ? 117.475 91.733  135.291 1.00 87.93  ? 631 THR B N     1 
ATOM   8949  C  CA    . THR B 1 639 ? 118.637 92.304  135.961 1.00 83.73  ? 631 THR B CA    1 
ATOM   8950  C  C     . THR B 1 639 ? 119.954 91.723  135.468 1.00 82.70  ? 631 THR B C     1 
ATOM   8951  O  O     . THR B 1 639 ? 121.008 92.295  135.764 1.00 80.52  ? 631 THR B O     1 
ATOM   8952  C  CB    . THR B 1 639 ? 118.538 92.099  137.474 1.00 85.11  ? 631 THR B CB    1 
ATOM   8953  O  OG1   . THR B 1 639 ? 118.391 90.703  137.762 1.00 90.69  ? 631 THR B OG1   1 
ATOM   8954  C  CG2   . THR B 1 639 ? 117.352 92.856  138.038 1.00 87.54  ? 631 THR B CG2   1 
ATOM   8955  N  N     . LYS B 1 640 ? 119.921 90.611  134.730 1.00 81.89  ? 632 LYS B N     1 
ATOM   8956  C  CA    . LYS B 1 640 ? 121.154 90.000  134.247 1.00 79.76  ? 632 LYS B CA    1 
ATOM   8957  C  C     . LYS B 1 640 ? 121.916 90.908  133.292 1.00 75.77  ? 632 LYS B C     1 
ATOM   8958  O  O     . LYS B 1 640 ? 123.135 90.760  133.158 1.00 75.74  ? 632 LYS B O     1 
ATOM   8959  C  CB    . LYS B 1 640 ? 120.850 88.671  133.555 1.00 84.26  ? 632 LYS B CB    1 
ATOM   8960  C  CG    . LYS B 1 640 ? 120.196 87.635  134.449 1.00 91.88  ? 632 LYS B CG    1 
ATOM   8961  C  CD    . LYS B 1 640 ? 119.948 86.340  133.692 1.00 98.35  ? 632 LYS B CD    1 
ATOM   8962  C  CE    . LYS B 1 640 ? 119.293 85.295  134.581 1.00 103.68 ? 632 LYS B CE    1 
ATOM   8963  N  NZ    . LYS B 1 640 ? 119.033 84.027  133.846 1.00 103.63 ? 632 LYS B NZ    1 
ATOM   8964  N  N     . GLY B 1 641 ? 121.228 91.838  132.627 1.00 71.04  ? 633 GLY B N     1 
ATOM   8965  C  CA    . GLY B 1 641 ? 121.899 92.689  131.659 1.00 70.29  ? 633 GLY B CA    1 
ATOM   8966  C  C     . GLY B 1 641 ? 122.965 93.569  132.283 1.00 65.42  ? 633 GLY B C     1 
ATOM   8967  O  O     . GLY B 1 641 ? 124.063 93.708  131.740 1.00 65.52  ? 633 GLY B O     1 
ATOM   8968  N  N     . HIS B 1 642 ? 122.660 94.169  133.433 1.00 62.22  ? 634 HIS B N     1 
ATOM   8969  C  CA    . HIS B 1 642 ? 123.594 95.058  134.114 1.00 61.55  ? 634 HIS B CA    1 
ATOM   8970  C  C     . HIS B 1 642 ? 123.967 94.548  135.501 1.00 65.48  ? 634 HIS B C     1 
ATOM   8971  O  O     . HIS B 1 642 ? 124.436 95.327  136.336 1.00 65.48  ? 634 HIS B O     1 
ATOM   8972  C  CB    . HIS B 1 642 ? 123.018 96.471  134.204 1.00 60.43  ? 634 HIS B CB    1 
ATOM   8973  C  CG    . HIS B 1 642 ? 122.915 97.163  132.881 1.00 56.98  ? 634 HIS B CG    1 
ATOM   8974  N  ND1   . HIS B 1 642 ? 123.814 98.123  132.472 1.00 57.43  ? 634 HIS B ND1   1 
ATOM   8975  C  CD2   . HIS B 1 642 ? 122.025 97.025  131.870 1.00 58.01  ? 634 HIS B CD2   1 
ATOM   8976  C  CE1   . HIS B 1 642 ? 123.480 98.551  131.268 1.00 55.76  ? 634 HIS B CE1   1 
ATOM   8977  N  NE2   . HIS B 1 642 ? 122.398 97.901  130.880 1.00 56.16  ? 634 HIS B NE2   1 
ATOM   8978  N  N     . ALA B 1 643 ? 123.759 93.260  135.766 1.00 64.40  ? 635 ALA B N     1 
ATOM   8979  C  CA    . ALA B 1 643 ? 124.180 92.694  137.046 1.00 60.89  ? 635 ALA B CA    1 
ATOM   8980  C  C     . ALA B 1 643 ? 125.683 92.805  137.273 1.00 60.89  ? 635 ALA B C     1 
ATOM   8981  O  O     . ALA B 1 643 ? 126.086 93.221  138.373 1.00 62.03  ? 635 ALA B O     1 
ATOM   8982  C  CB    . ALA B 1 643 ? 123.698 91.243  137.155 1.00 63.38  ? 635 ALA B CB    1 
ATOM   8983  N  N     . PRO B 1 644 ? 126.560 92.470  136.316 1.00 59.90  ? 636 PRO B N     1 
ATOM   8984  C  CA    . PRO B 1 644 ? 128.004 92.608  136.571 1.00 60.01  ? 636 PRO B CA    1 
ATOM   8985  C  C     . PRO B 1 644 ? 128.471 94.041  136.755 1.00 58.33  ? 636 PRO B C     1 
ATOM   8986  O  O     . PRO B 1 644 ? 129.654 94.246  137.055 1.00 55.37  ? 636 PRO B O     1 
ATOM   8987  C  CB    . PRO B 1 644 ? 128.644 91.981  135.326 1.00 54.02  ? 636 PRO B CB    1 
ATOM   8988  C  CG    . PRO B 1 644 ? 127.600 91.095  134.768 1.00 56.70  ? 636 PRO B CG    1 
ATOM   8989  C  CD    . PRO B 1 644 ? 126.313 91.797  135.028 1.00 58.30  ? 636 PRO B CD    1 
ATOM   8990  N  N     . THR B 1 645 ? 127.598 95.034  136.577 1.00 58.63  ? 637 THR B N     1 
ATOM   8991  C  CA    . THR B 1 645 ? 128.009 96.419  136.778 1.00 60.77  ? 637 THR B CA    1 
ATOM   8992  C  C     . THR B 1 645 ? 128.408 96.677  138.225 1.00 63.37  ? 637 THR B C     1 
ATOM   8993  O  O     . THR B 1 645 ? 129.231 97.560  138.494 1.00 65.21  ? 637 THR B O     1 
ATOM   8994  C  CB    . THR B 1 645 ? 126.887 97.369  136.359 1.00 60.18  ? 637 THR B CB    1 
ATOM   8995  O  OG1   . THR B 1 645 ? 126.327 96.930  135.116 1.00 56.00  ? 637 THR B OG1   1 
ATOM   8996  C  CG2   . THR B 1 645 ? 127.420 98.782  136.188 1.00 61.57  ? 637 THR B CG2   1 
ATOM   8997  N  N     . ASN B 1 646 ? 127.844 95.913  139.164 1.00 60.41  ? 638 ASN B N     1 
ATOM   8998  C  CA    . ASN B 1 646 ? 128.137 96.047  140.590 1.00 60.06  ? 638 ASN B CA    1 
ATOM   8999  C  C     . ASN B 1 646 ? 127.821 97.462  141.078 1.00 63.48  ? 638 ASN B C     1 
ATOM   9000  O  O     . ASN B 1 646 ? 128.699 98.226  141.483 1.00 64.03  ? 638 ASN B O     1 
ATOM   9001  C  CB    . ASN B 1 646 ? 129.592 95.664  140.889 1.00 60.32  ? 638 ASN B CB    1 
ATOM   9002  C  CG    . ASN B 1 646 ? 129.824 95.343  142.353 1.00 63.23  ? 638 ASN B CG    1 
ATOM   9003  O  OD1   . ASN B 1 646 ? 129.090 95.802  143.227 1.00 65.24  ? 638 ASN B OD1   1 
ATOM   9004  N  ND2   . ASN B 1 646 ? 130.853 94.550  142.626 1.00 60.51  ? 638 ASN B ND2   1 
ATOM   9005  N  N     . PHE B 1 647 ? 126.531 97.804  141.016 1.00 63.43  ? 639 PHE B N     1 
ATOM   9006  C  CA    . PHE B 1 647 ? 126.090 99.124  141.455 1.00 64.48  ? 639 PHE B CA    1 
ATOM   9007  C  C     . PHE B 1 647 ? 126.377 99.352  142.933 1.00 68.97  ? 639 PHE B C     1 
ATOM   9008  O  O     . PHE B 1 647 ? 126.614 100.492 143.349 1.00 67.48  ? 639 PHE B O     1 
ATOM   9009  C  CB    . PHE B 1 647 ? 124.598 99.300  141.177 1.00 64.60  ? 639 PHE B CB    1 
ATOM   9010  C  CG    . PHE B 1 647 ? 124.242 99.247  139.720 1.00 68.39  ? 639 PHE B CG    1 
ATOM   9011  C  CD1   . PHE B 1 647 ? 124.320 100.383 138.933 1.00 68.13  ? 639 PHE B CD1   1 
ATOM   9012  C  CD2   . PHE B 1 647 ? 123.823 98.063  139.139 1.00 67.79  ? 639 PHE B CD2   1 
ATOM   9013  C  CE1   . PHE B 1 647 ? 123.990 100.338 137.594 1.00 66.68  ? 639 PHE B CE1   1 
ATOM   9014  C  CE2   . PHE B 1 647 ? 123.492 98.013  137.799 1.00 68.21  ? 639 PHE B CE2   1 
ATOM   9015  C  CZ    . PHE B 1 647 ? 123.575 99.152  137.027 1.00 67.83  ? 639 PHE B CZ    1 
ATOM   9016  N  N     . ALA B 1 648 ? 126.355 98.288  143.740 1.00 68.38  ? 640 ALA B N     1 
ATOM   9017  C  CA    . ALA B 1 648 ? 126.636 98.434  145.164 1.00 66.89  ? 640 ALA B CA    1 
ATOM   9018  C  C     . ALA B 1 648 ? 128.043 98.967  145.394 1.00 66.85  ? 640 ALA B C     1 
ATOM   9019  O  O     . ALA B 1 648 ? 128.251 99.853  146.231 1.00 70.52  ? 640 ALA B O     1 
ATOM   9020  C  CB    . ALA B 1 648 ? 126.443 97.096  145.876 1.00 70.01  ? 640 ALA B CB    1 
ATOM   9021  N  N     . LYS B 1 649 ? 129.023 98.441  144.659 1.00 63.00  ? 641 LYS B N     1 
ATOM   9022  C  CA    . LYS B 1 649 ? 130.372 98.988  144.736 1.00 64.13  ? 641 LYS B CA    1 
ATOM   9023  C  C     . LYS B 1 649 ? 130.451 100.362 144.086 1.00 65.34  ? 641 LYS B C     1 
ATOM   9024  O  O     . LYS B 1 649 ? 131.238 101.210 144.522 1.00 67.95  ? 641 LYS B O     1 
ATOM   9025  C  CB    . LYS B 1 649 ? 131.365 98.028  144.082 1.00 60.25  ? 641 LYS B CB    1 
ATOM   9026  C  CG    . LYS B 1 649 ? 132.813 98.476  144.167 1.00 59.75  ? 641 LYS B CG    1 
ATOM   9027  C  CD    . LYS B 1 649 ? 133.749 97.441  143.572 1.00 59.00  ? 641 LYS B CD    1 
ATOM   9028  C  CE    . LYS B 1 649 ? 135.196 97.894  143.666 1.00 58.38  ? 641 LYS B CE    1 
ATOM   9029  N  NZ    . LYS B 1 649 ? 136.136 96.868  143.139 1.00 67.34  ? 641 LYS B NZ    1 
ATOM   9030  N  N     . TRP B 1 650 ? 129.638 100.603 143.055 1.00 64.47  ? 642 TRP B N     1 
ATOM   9031  C  CA    . TRP B 1 650 ? 129.668 101.882 142.355 1.00 64.45  ? 642 TRP B CA    1 
ATOM   9032  C  C     . TRP B 1 650 ? 129.139 103.022 143.216 1.00 65.92  ? 642 TRP B C     1 
ATOM   9033  O  O     . TRP B 1 650 ? 129.509 104.180 142.991 1.00 67.33  ? 642 TRP B O     1 
ATOM   9034  C  CB    . TRP B 1 650 ? 128.862 101.781 141.058 1.00 63.95  ? 642 TRP B CB    1 
ATOM   9035  C  CG    . TRP B 1 650 ? 128.763 103.070 140.304 1.00 60.48  ? 642 TRP B CG    1 
ATOM   9036  C  CD1   . TRP B 1 650 ? 129.695 103.603 139.463 1.00 61.85  ? 642 TRP B CD1   1 
ATOM   9037  C  CD2   . TRP B 1 650 ? 127.666 103.989 140.320 1.00 56.30  ? 642 TRP B CD2   1 
ATOM   9038  N  NE1   . TRP B 1 650 ? 129.249 104.799 138.958 1.00 59.05  ? 642 TRP B NE1   1 
ATOM   9039  C  CE2   . TRP B 1 650 ? 128.004 105.057 139.469 1.00 57.43  ? 642 TRP B CE2   1 
ATOM   9040  C  CE3   . TRP B 1 650 ? 126.432 104.012 140.975 1.00 56.80  ? 642 TRP B CE3   1 
ATOM   9041  C  CZ2   . TRP B 1 650 ? 127.154 106.137 139.255 1.00 59.24  ? 642 TRP B CZ2   1 
ATOM   9042  C  CZ3   . TRP B 1 650 ? 125.591 105.085 140.762 1.00 57.63  ? 642 TRP B CZ3   1 
ATOM   9043  C  CH2   . TRP B 1 650 ? 125.954 106.131 139.908 1.00 58.47  ? 642 TRP B CH2   1 
ATOM   9044  N  N     . ARG B 1 651 ? 128.283 102.720 144.195 1.00 67.83  ? 643 ARG B N     1 
ATOM   9045  C  CA    . ARG B 1 651 ? 127.699 103.775 145.020 1.00 70.85  ? 643 ARG B CA    1 
ATOM   9046  C  C     . ARG B 1 651 ? 128.768 104.539 145.793 1.00 71.25  ? 643 ARG B C     1 
ATOM   9047  O  O     . ARG B 1 651 ? 128.718 105.772 145.879 1.00 73.48  ? 643 ARG B O     1 
ATOM   9048  C  CB    . ARG B 1 651 ? 126.668 103.182 145.981 1.00 73.30  ? 643 ARG B CB    1 
ATOM   9049  C  CG    . ARG B 1 651 ? 125.406 102.670 145.308 1.00 72.52  ? 643 ARG B CG    1 
ATOM   9050  C  CD    . ARG B 1 651 ? 124.483 101.993 146.308 1.00 75.31  ? 643 ARG B CD    1 
ATOM   9051  N  NE    . ARG B 1 651 ? 124.033 102.911 147.347 1.00 75.58  ? 643 ARG B NE    1 
ATOM   9052  C  CZ    . ARG B 1 651 ? 122.874 103.555 147.326 1.00 77.20  ? 643 ARG B CZ    1 
ATOM   9053  N  NH1   . ARG B 1 651 ? 122.012 103.394 146.336 1.00 78.96  ? 643 ARG B NH1   1 
ATOM   9054  N  NH2   . ARG B 1 651 ? 122.572 104.379 148.325 1.00 76.68  ? 643 ARG B NH2   1 
ATOM   9055  N  N     . THR B 1 652 ? 129.738 103.830 146.363 1.00 69.54  ? 644 THR B N     1 
ATOM   9056  C  CA    . THR B 1 652 ? 130.783 104.448 147.167 1.00 71.97  ? 644 THR B CA    1 
ATOM   9057  C  C     . THR B 1 652 ? 132.119 104.553 146.443 1.00 75.17  ? 644 THR B C     1 
ATOM   9058  O  O     . THR B 1 652 ? 133.086 105.048 147.029 1.00 78.15  ? 644 THR B O     1 
ATOM   9059  C  CB    . THR B 1 652 ? 130.971 103.670 148.472 1.00 77.56  ? 644 THR B CB    1 
ATOM   9060  O  OG1   . THR B 1 652 ? 131.288 102.305 148.174 1.00 72.49  ? 644 THR B OG1   1 
ATOM   9061  C  CG2   . THR B 1 652 ? 129.701 103.719 149.307 1.00 80.71  ? 644 THR B CG2   1 
ATOM   9062  N  N     . ALA B 1 653 ? 132.198 104.105 145.193 1.00 75.25  ? 645 ALA B N     1 
ATOM   9063  C  CA    . ALA B 1 653 ? 133.465 104.109 144.476 1.00 73.88  ? 645 ALA B CA    1 
ATOM   9064  C  C     . ALA B 1 653 ? 133.883 105.527 144.109 1.00 79.17  ? 645 ALA B C     1 
ATOM   9065  O  O     . ALA B 1 653 ? 133.053 106.365 143.749 1.00 77.56  ? 645 ALA B O     1 
ATOM   9066  C  CB    . ALA B 1 653 ? 133.365 103.253 143.215 1.00 67.88  ? 645 ALA B CB    1 
ATOM   9067  N  N     . THR B 1 654 ? 135.187 105.791 144.205 1.00 82.42  ? 646 THR B N     1 
ATOM   9068  C  CA    . THR B 1 654 ? 135.755 107.071 143.814 1.00 80.36  ? 646 THR B CA    1 
ATOM   9069  C  C     . THR B 1 654 ? 136.745 106.968 142.663 1.00 72.31  ? 646 THR B C     1 
ATOM   9070  O  O     . THR B 1 654 ? 137.142 108.006 142.121 1.00 69.96  ? 646 THR B O     1 
ATOM   9071  C  CB    . THR B 1 654 ? 136.453 107.741 145.008 1.00 87.06  ? 646 THR B CB    1 
ATOM   9072  O  OG1   . THR B 1 654 ? 137.516 106.902 145.476 1.00 86.14  ? 646 THR B OG1   1 
ATOM   9073  C  CG2   . THR B 1 654 ? 135.464 107.974 146.138 1.00 83.92  ? 646 THR B CG2   1 
ATOM   9074  N  N     . THR B 1 655 ? 137.156 105.764 142.281 1.00 72.79  ? 647 THR B N     1 
ATOM   9075  C  CA    . THR B 1 655 ? 138.065 105.530 141.171 1.00 74.70  ? 647 THR B CA    1 
ATOM   9076  C  C     . THR B 1 655 ? 137.490 104.455 140.262 1.00 73.35  ? 647 THR B C     1 
ATOM   9077  O  O     . THR B 1 655 ? 136.747 103.582 140.722 1.00 74.58  ? 647 THR B O     1 
ATOM   9078  C  CB    . THR B 1 655 ? 139.452 105.091 141.666 1.00 73.76  ? 647 THR B CB    1 
ATOM   9079  O  OG1   . THR B 1 655 ? 139.328 103.899 142.451 1.00 75.81  ? 647 THR B OG1   1 
ATOM   9080  C  CG2   . THR B 1 655 ? 140.091 106.184 142.508 1.00 74.49  ? 647 THR B CG2   1 
ATOM   9081  N  N     . PRO B 1 656 ? 137.807 104.498 138.967 1.00 68.05  ? 648 PRO B N     1 
ATOM   9082  C  CA    . PRO B 1 656 ? 137.294 103.469 138.053 1.00 67.14  ? 648 PRO B CA    1 
ATOM   9083  C  C     . PRO B 1 656 ? 137.778 102.086 138.457 1.00 62.04  ? 648 PRO B C     1 
ATOM   9084  O  O     . PRO B 1 656 ? 138.913 101.913 138.905 1.00 62.06  ? 648 PRO B O     1 
ATOM   9085  C  CB    . PRO B 1 656 ? 137.862 103.889 136.692 1.00 71.80  ? 648 PRO B CB    1 
ATOM   9086  C  CG    . PRO B 1 656 ? 138.169 105.343 136.837 1.00 71.61  ? 648 PRO B CG    1 
ATOM   9087  C  CD    . PRO B 1 656 ? 138.587 105.527 138.260 1.00 68.56  ? 648 PRO B CD    1 
ATOM   9088  N  N     . TYR B 1 657 ? 136.907 101.093 138.296 1.00 60.44  ? 649 TYR B N     1 
ATOM   9089  C  CA    . TYR B 1 657 ? 137.230 99.735  138.708 1.00 60.70  ? 649 TYR B CA    1 
ATOM   9090  C  C     . TYR B 1 657 ? 136.870 98.745  137.610 1.00 61.45  ? 649 TYR B C     1 
ATOM   9091  O  O     . TYR B 1 657 ? 135.891 98.925  136.885 1.00 64.51  ? 649 TYR B O     1 
ATOM   9092  C  CB    . TYR B 1 657 ? 136.515 99.358  140.013 1.00 60.68  ? 649 TYR B CB    1 
ATOM   9093  C  CG    . TYR B 1 657 ? 135.007 99.420  139.948 1.00 60.13  ? 649 TYR B CG    1 
ATOM   9094  C  CD1   . TYR B 1 657 ? 134.330 100.608 140.186 1.00 60.93  ? 649 TYR B CD1   1 
ATOM   9095  C  CD2   . TYR B 1 657 ? 134.260 98.285  139.666 1.00 59.90  ? 649 TYR B CD2   1 
ATOM   9096  C  CE1   . TYR B 1 657 ? 132.952 100.664 140.134 1.00 61.19  ? 649 TYR B CE1   1 
ATOM   9097  C  CE2   . TYR B 1 657 ? 132.884 98.333  139.612 1.00 60.92  ? 649 TYR B CE2   1 
ATOM   9098  C  CZ    . TYR B 1 657 ? 132.235 99.523  139.847 1.00 59.90  ? 649 TYR B CZ    1 
ATOM   9099  O  OH    . TYR B 1 657 ? 130.863 99.569  139.794 1.00 61.07  ? 649 TYR B OH    1 
ATOM   9100  N  N     . ARG B 1 658 ? 137.673 97.692  137.499 1.00 61.18  ? 650 ARG B N     1 
ATOM   9101  C  CA    . ARG B 1 658 ? 137.467 96.688  136.467 1.00 55.78  ? 650 ARG B CA    1 
ATOM   9102  C  C     . ARG B 1 658 ? 136.448 95.648  136.915 1.00 57.62  ? 650 ARG B C     1 
ATOM   9103  O  O     . ARG B 1 658 ? 136.411 95.254  138.083 1.00 64.09  ? 650 ARG B O     1 
ATOM   9104  C  CB    . ARG B 1 658 ? 138.788 96.003  136.118 1.00 56.37  ? 650 ARG B CB    1 
ATOM   9105  C  CG    . ARG B 1 658 ? 138.665 94.922  135.056 1.00 61.27  ? 650 ARG B CG    1 
ATOM   9106  C  CD    . ARG B 1 658 ? 140.001 94.264  134.765 1.00 69.17  ? 650 ARG B CD    1 
ATOM   9107  N  NE    . ARG B 1 658 ? 139.869 93.180  133.799 1.00 75.61  ? 650 ARG B NE    1 
ATOM   9108  C  CZ    . ARG B 1 658 ? 140.882 92.464  133.332 1.00 81.89  ? 650 ARG B CZ    1 
ATOM   9109  N  NH1   . ARG B 1 658 ? 142.126 92.694  133.717 1.00 82.67  ? 650 ARG B NH1   1 
ATOM   9110  N  NH2   . ARG B 1 658 ? 140.641 91.494  132.455 1.00 84.31  ? 650 ARG B NH2   1 
ATOM   9111  N  N     . VAL B 1 659 ? 135.617 95.206  135.973 1.00 54.24  ? 651 VAL B N     1 
ATOM   9112  C  CA    . VAL B 1 659 ? 134.671 94.124  136.197 1.00 52.99  ? 651 VAL B CA    1 
ATOM   9113  C  C     . VAL B 1 659 ? 134.951 93.024  135.179 1.00 53.51  ? 651 VAL B C     1 
ATOM   9114  O  O     . VAL B 1 659 ? 135.747 93.187  134.255 1.00 50.73  ? 651 VAL B O     1 
ATOM   9115  C  CB    . VAL B 1 659 ? 133.206 94.592  136.113 1.00 53.57  ? 651 VAL B CB    1 
ATOM   9116  C  CG1   . VAL B 1 659 ? 132.933 95.666  137.152 1.00 54.04  ? 651 VAL B CG1   1 
ATOM   9117  C  CG2   . VAL B 1 659 ? 132.892 95.099  134.719 1.00 57.18  ? 651 VAL B CG2   1 
ATOM   9118  N  N     . GLU B 1 660 ? 134.284 91.890  135.365 1.00 57.54  ? 652 GLU B N     1 
ATOM   9119  C  CA    . GLU B 1 660 ? 134.487 90.719  134.527 1.00 57.37  ? 652 GLU B CA    1 
ATOM   9120  C  C     . GLU B 1 660 ? 133.214 90.399  133.757 1.00 56.30  ? 652 GLU B C     1 
ATOM   9121  O  O     . GLU B 1 660 ? 132.102 90.672  134.219 1.00 55.64  ? 652 GLU B O     1 
ATOM   9122  C  CB    . GLU B 1 660 ? 134.911 89.505  135.362 1.00 60.53  ? 652 GLU B CB    1 
ATOM   9123  C  CG    . GLU B 1 660 ? 136.173 89.725  136.180 1.00 62.84  ? 652 GLU B CG    1 
ATOM   9124  C  CD    . GLU B 1 660 ? 137.401 89.941  135.317 1.00 70.57  ? 652 GLU B CD    1 
ATOM   9125  O  OE1   . GLU B 1 660 ? 137.444 89.399  134.193 1.00 72.60  ? 652 GLU B OE1   1 
ATOM   9126  O  OE2   . GLU B 1 660 ? 138.324 90.656  135.762 1.00 72.24  ? 652 GLU B OE2   1 
ATOM   9127  N  N     . TRP B 1 661 ? 133.391 89.816  132.576 1.00 55.92  ? 653 TRP B N     1 
ATOM   9128  C  CA    . TRP B 1 661 ? 132.257 89.478  131.729 1.00 59.78  ? 653 TRP B CA    1 
ATOM   9129  C  C     . TRP B 1 661 ? 131.431 88.360  132.352 1.00 58.97  ? 653 TRP B C     1 
ATOM   9130  O  O     . TRP B 1 661 ? 131.969 87.433  132.963 1.00 61.91  ? 653 TRP B O     1 
ATOM   9131  C  CB    . TRP B 1 661 ? 132.742 89.060  130.342 1.00 60.55  ? 653 TRP B CB    1 
ATOM   9132  C  CG    . TRP B 1 661 ? 131.633 88.713  129.398 1.00 66.31  ? 653 TRP B CG    1 
ATOM   9133  C  CD1   . TRP B 1 661 ? 131.015 89.550  128.519 1.00 66.88  ? 653 TRP B CD1   1 
ATOM   9134  C  CD2   . TRP B 1 661 ? 131.009 87.433  129.240 1.00 70.63  ? 653 TRP B CD2   1 
ATOM   9135  N  NE1   . TRP B 1 661 ? 130.044 88.873  127.822 1.00 69.57  ? 653 TRP B NE1   1 
ATOM   9136  C  CE2   . TRP B 1 661 ? 130.021 87.571  128.247 1.00 74.35  ? 653 TRP B CE2   1 
ATOM   9137  C  CE3   . TRP B 1 661 ? 131.190 86.184  129.842 1.00 70.24  ? 653 TRP B CE3   1 
ATOM   9138  C  CZ2   . TRP B 1 661 ? 129.217 86.509  127.843 1.00 79.56  ? 653 TRP B CZ2   1 
ATOM   9139  C  CZ3   . TRP B 1 661 ? 130.391 85.132  129.440 1.00 74.28  ? 653 TRP B CZ3   1 
ATOM   9140  C  CH2   . TRP B 1 661 ? 129.417 85.301  128.451 1.00 78.03  ? 653 TRP B CH2   1 
ATOM   9141  N  N     . GLU B 1 662 ? 130.113 88.453  132.194 1.00 57.32  ? 654 GLU B N     1 
ATOM   9142  C  CA    . GLU B 1 662 ? 129.196 87.414  132.634 1.00 62.09  ? 654 GLU B CA    1 
ATOM   9143  C  C     . GLU B 1 662 ? 128.149 87.197  131.551 1.00 66.46  ? 654 GLU B C     1 
ATOM   9144  O  O     . GLU B 1 662 ? 128.093 87.925  130.558 1.00 68.57  ? 654 GLU B O     1 
ATOM   9145  C  CB    . GLU B 1 662 ? 128.532 87.769  133.970 1.00 63.86  ? 654 GLU B CB    1 
ATOM   9146  C  CG    . GLU B 1 662 ? 129.506 87.904  135.131 1.00 72.68  ? 654 GLU B CG    1 
ATOM   9147  C  CD    . GLU B 1 662 ? 128.815 88.214  136.444 1.00 75.88  ? 654 GLU B CD    1 
ATOM   9148  O  OE1   . GLU B 1 662 ? 127.579 88.052  136.520 1.00 79.72  ? 654 GLU B OE1   1 
ATOM   9149  O  OE2   . GLU B 1 662 ? 129.507 88.623  137.399 1.00 74.40  ? 654 GLU B OE2   1 
ATOM   9150  N  N     . ALA B 1 663 ? 127.316 86.178  131.750 1.00 68.73  ? 655 ALA B N     1 
ATOM   9151  C  CA    . ALA B 1 663 ? 126.316 85.825  130.751 1.00 69.88  ? 655 ALA B CA    1 
ATOM   9152  C  C     . ALA B 1 663 ? 125.323 86.963  130.548 1.00 70.71  ? 655 ALA B C     1 
ATOM   9153  O  O     . ALA B 1 663 ? 124.845 87.573  131.509 1.00 67.72  ? 655 ALA B O     1 
ATOM   9154  C  CB    . ALA B 1 663 ? 125.579 84.552  131.166 1.00 73.51  ? 655 ALA B CB    1 
ATOM   9155  N  N     . ASP B 1 664 ? 125.024 87.249  129.280 1.00 74.10  ? 656 ASP B N     1 
ATOM   9156  C  CA    . ASP B 1 664 ? 124.072 88.280  128.868 1.00 67.05  ? 656 ASP B CA    1 
ATOM   9157  C  C     . ASP B 1 664 ? 124.471 89.673  129.342 1.00 59.99  ? 656 ASP B C     1 
ATOM   9158  O  O     . ASP B 1 664 ? 123.617 90.555  129.469 1.00 59.56  ? 656 ASP B O     1 
ATOM   9159  C  CB    . ASP B 1 664 ? 122.651 87.949  129.341 1.00 75.07  ? 656 ASP B CB    1 
ATOM   9160  C  CG    . ASP B 1 664 ? 122.122 86.664  128.737 1.00 82.20  ? 656 ASP B CG    1 
ATOM   9161  O  OD1   . ASP B 1 664 ? 122.546 86.312  127.617 1.00 80.29  ? 656 ASP B OD1   1 
ATOM   9162  O  OD2   . ASP B 1 664 ? 121.282 86.004  129.383 1.00 91.26  ? 656 ASP B OD2   1 
ATOM   9163  N  N     . PHE B 1 665 ? 125.756 89.891  129.608 1.00 55.91  ? 657 PHE B N     1 
ATOM   9164  C  CA    . PHE B 1 665 ? 126.232 91.222  129.955 1.00 53.46  ? 657 PHE B CA    1 
ATOM   9165  C  C     . PHE B 1 665 ? 126.123 92.146  128.748 1.00 59.79  ? 657 PHE B C     1 
ATOM   9166  O  O     . PHE B 1 665 ? 126.485 91.774  127.628 1.00 61.01  ? 657 PHE B O     1 
ATOM   9167  C  CB    . PHE B 1 665 ? 127.680 91.155  130.439 1.00 49.99  ? 657 PHE B CB    1 
ATOM   9168  C  CG    . PHE B 1 665 ? 128.147 92.396  131.142 1.00 46.47  ? 657 PHE B CG    1 
ATOM   9169  C  CD1   . PHE B 1 665 ? 127.244 93.248  131.751 1.00 47.61  ? 657 PHE B CD1   1 
ATOM   9170  C  CD2   . PHE B 1 665 ? 129.493 92.713  131.189 1.00 47.39  ? 657 PHE B CD2   1 
ATOM   9171  C  CE1   . PHE B 1 665 ? 127.675 94.390  132.396 1.00 50.51  ? 657 PHE B CE1   1 
ATOM   9172  C  CE2   . PHE B 1 665 ? 129.929 93.852  131.833 1.00 46.70  ? 657 PHE B CE2   1 
ATOM   9173  C  CZ    . PHE B 1 665 ? 129.019 94.692  132.437 1.00 49.63  ? 657 PHE B CZ    1 
ATOM   9174  N  N     . GLU B 1 666 ? 125.621 93.357  128.976 1.00 54.98  ? 658 GLU B N     1 
ATOM   9175  C  CA    . GLU B 1 666 ? 125.436 94.337  127.905 1.00 47.42  ? 658 GLU B CA    1 
ATOM   9176  C  C     . GLU B 1 666 ? 125.455 95.742  128.483 1.00 45.94  ? 658 GLU B C     1 
ATOM   9177  O  O     . GLU B 1 666 ? 124.411 96.385  128.645 1.00 48.49  ? 658 GLU B O     1 
ATOM   9178  C  CB    . GLU B 1 666 ? 124.137 94.077  127.142 1.00 54.19  ? 658 GLU B CB    1 
ATOM   9179  C  CG    . GLU B 1 666 ? 122.971 93.660  128.021 1.00 54.85  ? 658 GLU B CG    1 
ATOM   9180  C  CD    . GLU B 1 666 ? 121.701 93.432  127.230 1.00 65.60  ? 658 GLU B CD    1 
ATOM   9181  O  OE1   . GLU B 1 666 ? 121.671 93.794  126.035 1.00 69.67  ? 658 GLU B OE1   1 
ATOM   9182  O  OE2   . GLU B 1 666 ? 120.731 92.891  127.800 1.00 74.69  ? 658 GLU B OE2   1 
ATOM   9183  N  N     . PRO B 1 667 ? 126.633 96.260  128.801 1.00 44.70  ? 659 PRO B N     1 
ATOM   9184  C  CA    . PRO B 1 667 ? 126.746 97.638  129.284 1.00 45.21  ? 659 PRO B CA    1 
ATOM   9185  C  C     . PRO B 1 667 ? 126.787 98.623  128.119 1.00 48.04  ? 659 PRO B C     1 
ATOM   9186  O  O     . PRO B 1 667 ? 126.646 98.259  126.954 1.00 45.78  ? 659 PRO B O     1 
ATOM   9187  C  CB    . PRO B 1 667 ? 128.066 97.619  130.053 1.00 40.66  ? 659 PRO B CB    1 
ATOM   9188  C  CG    . PRO B 1 667 ? 128.882 96.617  129.327 1.00 43.47  ? 659 PRO B CG    1 
ATOM   9189  C  CD    . PRO B 1 667 ? 127.927 95.558  128.842 1.00 46.50  ? 659 PRO B CD    1 
ATOM   9190  N  N     . TYR B 1 668 ? 126.979 99.894  128.459 1.00 49.19  ? 660 TYR B N     1 
ATOM   9191  C  CA    . TYR B 1 668 ? 127.134 100.967 127.485 1.00 45.03  ? 660 TYR B CA    1 
ATOM   9192  C  C     . TYR B 1 668 ? 128.547 101.519 127.608 1.00 46.94  ? 660 TYR B C     1 
ATOM   9193  O  O     . TYR B 1 668 ? 128.899 102.114 128.633 1.00 51.85  ? 660 TYR B O     1 
ATOM   9194  C  CB    . TYR B 1 668 ? 126.087 102.058 127.699 1.00 45.73  ? 660 TYR B CB    1 
ATOM   9195  C  CG    . TYR B 1 668 ? 124.679 101.559 127.481 1.00 44.66  ? 660 TYR B CG    1 
ATOM   9196  C  CD1   . TYR B 1 668 ? 124.111 101.563 126.217 1.00 46.88  ? 660 TYR B CD1   1 
ATOM   9197  C  CD2   . TYR B 1 668 ? 123.927 101.061 128.534 1.00 46.26  ? 660 TYR B CD2   1 
ATOM   9198  C  CE1   . TYR B 1 668 ? 122.831 101.096 126.008 1.00 44.50  ? 660 TYR B CE1   1 
ATOM   9199  C  CE2   . TYR B 1 668 ? 122.646 100.592 128.335 1.00 47.09  ? 660 TYR B CE2   1 
ATOM   9200  C  CZ    . TYR B 1 668 ? 122.103 100.613 127.070 1.00 42.42  ? 660 TYR B CZ    1 
ATOM   9201  O  OH    . TYR B 1 668 ? 120.827 100.145 126.864 1.00 43.13  ? 660 TYR B OH    1 
ATOM   9202  N  N     . VAL B 1 669 ? 129.343 101.343 126.557 1.00 44.51  ? 661 VAL B N     1 
ATOM   9203  C  CA    . VAL B 1 669 ? 130.791 101.466 126.643 1.00 43.85  ? 661 VAL B CA    1 
ATOM   9204  C  C     . VAL B 1 669 ? 131.279 102.624 125.785 1.00 45.20  ? 661 VAL B C     1 
ATOM   9205  O  O     . VAL B 1 669 ? 130.744 102.890 124.702 1.00 46.20  ? 661 VAL B O     1 
ATOM   9206  C  CB    . VAL B 1 669 ? 131.484 100.153 126.223 1.00 43.84  ? 661 VAL B CB    1 
ATOM   9207  C  CG1   . VAL B 1 669 ? 131.176 99.052  127.221 1.00 44.70  ? 661 VAL B CG1   1 
ATOM   9208  C  CG2   . VAL B 1 669 ? 131.042 99.740  124.830 1.00 46.27  ? 661 VAL B CG2   1 
ATOM   9209  N  N     . VAL B 1 670 ? 132.289 103.320 126.294 1.00 43.84  ? 662 VAL B N     1 
ATOM   9210  C  CA    . VAL B 1 670 ? 133.117 104.230 125.517 1.00 47.07  ? 662 VAL B CA    1 
ATOM   9211  C  C     . VAL B 1 670 ? 134.359 103.461 125.094 1.00 48.74  ? 662 VAL B C     1 
ATOM   9212  O  O     . VAL B 1 670 ? 135.050 102.873 125.939 1.00 51.44  ? 662 VAL B O     1 
ATOM   9213  C  CB    . VAL B 1 670 ? 133.494 105.479 126.329 1.00 44.45  ? 662 VAL B CB    1 
ATOM   9214  C  CG1   . VAL B 1 670 ? 134.294 106.446 125.476 1.00 45.10  ? 662 VAL B CG1   1 
ATOM   9215  C  CG2   . VAL B 1 670 ? 132.251 106.145 126.882 1.00 45.92  ? 662 VAL B CG2   1 
ATOM   9216  N  N     . VAL B 1 671 ? 134.628 103.443 123.789 1.00 52.13  ? 663 VAL B N     1 
ATOM   9217  C  CA    . VAL B 1 671 ? 135.703 102.662 123.194 1.00 53.24  ? 663 VAL B CA    1 
ATOM   9218  C  C     . VAL B 1 671 ? 136.421 103.526 122.164 1.00 54.99  ? 663 VAL B C     1 
ATOM   9219  O  O     . VAL B 1 671 ? 136.093 104.699 121.966 1.00 53.32  ? 663 VAL B O     1 
ATOM   9220  C  CB    . VAL B 1 671 ? 135.186 101.364 122.542 1.00 49.02  ? 663 VAL B CB    1 
ATOM   9221  C  CG1   . VAL B 1 671 ? 134.670 100.404 123.595 1.00 49.85  ? 663 VAL B CG1   1 
ATOM   9222  C  CG2   . VAL B 1 671 ? 134.095 101.684 121.540 1.00 52.20  ? 663 VAL B CG2   1 
ATOM   9223  N  N     . ARG B 1 672 ? 137.408 102.932 121.498 1.00 58.54  ? 664 ARG B N     1 
ATOM   9224  C  CA    . ARG B 1 672 ? 138.144 103.610 120.444 1.00 64.46  ? 664 ARG B CA    1 
ATOM   9225  C  C     . ARG B 1 672 ? 137.358 103.565 119.135 1.00 67.11  ? 664 ARG B C     1 
ATOM   9226  O  O     . ARG B 1 672 ? 136.297 102.944 119.033 1.00 70.39  ? 664 ARG B O     1 
ATOM   9227  C  CB    . ARG B 1 672 ? 139.523 102.982 120.265 1.00 64.79  ? 664 ARG B CB    1 
ATOM   9228  C  CG    . ARG B 1 672 ? 140.412 103.059 121.487 1.00 73.05  ? 664 ARG B CG    1 
ATOM   9229  C  CD    . ARG B 1 672 ? 141.768 102.441 121.198 1.00 83.03  ? 664 ARG B CD    1 
ATOM   9230  N  NE    . ARG B 1 672 ? 141.644 101.082 120.684 1.00 83.58  ? 664 ARG B NE    1 
ATOM   9231  C  CZ    . ARG B 1 672 ? 142.667 100.324 120.317 1.00 86.05  ? 664 ARG B CZ    1 
ATOM   9232  N  NH1   . ARG B 1 672 ? 143.913 100.762 120.392 1.00 90.73  ? 664 ARG B NH1   1 
ATOM   9233  N  NH2   . ARG B 1 672 ? 142.435 99.096  119.862 1.00 83.75  ? 664 ARG B NH2   1 
ATOM   9234  N  N     . ARG B 1 673 ? 137.895 104.234 118.114 1.00 61.06  ? 665 ARG B N     1 
ATOM   9235  C  CA    . ARG B 1 673 ? 137.218 104.282 116.822 1.00 55.97  ? 665 ARG B CA    1 
ATOM   9236  C  C     . ARG B 1 673 ? 137.233 102.923 116.133 1.00 61.70  ? 665 ARG B C     1 
ATOM   9237  O  O     . ARG B 1 673 ? 136.281 102.570 115.427 1.00 61.15  ? 665 ARG B O     1 
ATOM   9238  C  CB    . ARG B 1 673 ? 137.865 105.344 115.935 1.00 61.31  ? 665 ARG B CB    1 
ATOM   9239  C  CG    . ARG B 1 673 ? 137.105 105.635 114.656 1.00 61.59  ? 665 ARG B CG    1 
ATOM   9240  C  CD    . ARG B 1 673 ? 137.690 106.835 113.934 1.00 62.28  ? 665 ARG B CD    1 
ATOM   9241  N  NE    . ARG B 1 673 ? 136.883 107.223 112.785 1.00 65.95  ? 665 ARG B NE    1 
ATOM   9242  C  CZ    . ARG B 1 673 ? 137.109 108.297 112.041 1.00 68.06  ? 665 ARG B CZ    1 
ATOM   9243  N  NH1   . ARG B 1 673 ? 138.114 109.117 112.299 1.00 73.44  ? 665 ARG B NH1   1 
ATOM   9244  N  NH2   . ARG B 1 673 ? 136.305 108.555 111.014 1.00 64.90  ? 665 ARG B NH2   1 
ATOM   9245  N  N     . ASP B 1 674 ? 138.297 102.143 116.332 1.00 65.51  ? 666 ASP B N     1 
ATOM   9246  C  CA    . ASP B 1 674 ? 138.477 100.866 115.649 1.00 64.05  ? 666 ASP B CA    1 
ATOM   9247  C  C     . ASP B 1 674 ? 137.850 99.699  116.402 1.00 66.54  ? 666 ASP B C     1 
ATOM   9248  O  O     . ASP B 1 674 ? 138.304 98.557  116.254 1.00 63.84  ? 666 ASP B O     1 
ATOM   9249  C  CB    . ASP B 1 674 ? 139.963 100.606 115.405 1.00 66.91  ? 666 ASP B CB    1 
ATOM   9250  C  CG    . ASP B 1 674 ? 140.765 100.572 116.687 1.00 79.03  ? 666 ASP B CG    1 
ATOM   9251  O  OD1   . ASP B 1 674 ? 140.425 101.328 117.620 1.00 79.32  ? 666 ASP B OD1   1 
ATOM   9252  O  OD2   . ASP B 1 674 ? 141.735 99.790  116.765 1.00 82.80  ? 666 ASP B OD2   1 
ATOM   9253  N  N     . CYS B 1 675 ? 136.829 99.957  117.209 1.00 66.70  ? 667 CYS B N     1 
ATOM   9254  C  CA    . CYS B 1 675 ? 136.141 98.884  117.909 1.00 59.66  ? 667 CYS B CA    1 
ATOM   9255  C  C     . CYS B 1 675 ? 135.487 97.940  116.902 1.00 58.91  ? 667 CYS B C     1 
ATOM   9256  O  O     . CYS B 1 675 ? 135.033 98.383  115.841 1.00 63.79  ? 667 CYS B O     1 
ATOM   9257  C  CB    . CYS B 1 675 ? 135.090 99.468  118.855 1.00 58.43  ? 667 CYS B CB    1 
ATOM   9258  S  SG    . CYS B 1 675 ? 133.799 98.330  119.408 1.00 67.50  ? 667 CYS B SG    1 
ATOM   9259  N  N     . PRO B 1 676 ? 135.442 96.638  117.185 1.00 55.35  ? 668 PRO B N     1 
ATOM   9260  C  CA    . PRO B 1 676 ? 134.781 95.708  116.263 1.00 52.50  ? 668 PRO B CA    1 
ATOM   9261  C  C     . PRO B 1 676 ? 133.314 96.061  116.066 1.00 51.88  ? 668 PRO B C     1 
ATOM   9262  O  O     . PRO B 1 676 ? 132.634 96.520  116.986 1.00 52.62  ? 668 PRO B O     1 
ATOM   9263  C  CB    . PRO B 1 676 ? 134.947 94.345  116.948 1.00 54.98  ? 668 PRO B CB    1 
ATOM   9264  C  CG    . PRO B 1 676 ? 135.302 94.656  118.366 1.00 58.51  ? 668 PRO B CG    1 
ATOM   9265  C  CD    . PRO B 1 676 ? 136.070 95.935  118.315 1.00 58.70  ? 668 PRO B CD    1 
ATOM   9266  N  N     . GLU B 1 677 ? 132.834 95.845  114.846 1.00 51.49  ? 669 GLU B N     1 
ATOM   9267  C  CA    . GLU B 1 677 ? 131.483 96.225  114.474 1.00 53.29  ? 669 GLU B CA    1 
ATOM   9268  C  C     . GLU B 1 677 ? 130.462 95.231  115.019 1.00 47.39  ? 669 GLU B C     1 
ATOM   9269  O  O     . GLU B 1 677 ? 130.789 94.108  115.410 1.00 47.66  ? 669 GLU B O     1 
ATOM   9270  C  CB    . GLU B 1 677 ? 131.356 96.319  112.954 1.00 56.02  ? 669 GLU B CB    1 
ATOM   9271  C  CG    . GLU B 1 677 ? 132.294 97.327  112.314 1.00 62.46  ? 669 GLU B CG    1 
ATOM   9272  C  CD    . GLU B 1 677 ? 132.167 97.361  110.804 1.00 78.67  ? 669 GLU B CD    1 
ATOM   9273  O  OE1   . GLU B 1 677 ? 131.459 96.496  110.247 1.00 81.35  ? 669 GLU B OE1   1 
ATOM   9274  O  OE2   . GLU B 1 677 ? 132.773 98.252  110.174 1.00 85.07  ? 669 GLU B OE2   1 
ATOM   9275  N  N     . TYR B 1 678 ? 129.207 95.668  115.041 1.00 47.08  ? 670 TYR B N     1 
ATOM   9276  C  CA    . TYR B 1 678 ? 128.107 94.802  115.429 1.00 46.71  ? 670 TYR B CA    1 
ATOM   9277  C  C     . TYR B 1 678 ? 127.827 93.778  114.334 1.00 48.80  ? 670 TYR B C     1 
ATOM   9278  O  O     . TYR B 1 678 ? 128.162 93.970  113.163 1.00 50.99  ? 670 TYR B O     1 
ATOM   9279  C  CB    . TYR B 1 678 ? 126.847 95.623  115.708 1.00 49.00  ? 670 TYR B CB    1 
ATOM   9280  C  CG    . TYR B 1 678 ? 126.910 96.468  116.961 1.00 48.09  ? 670 TYR B CG    1 
ATOM   9281  C  CD1   . TYR B 1 678 ? 127.750 97.570  117.041 1.00 47.39  ? 670 TYR B CD1   1 
ATOM   9282  C  CD2   . TYR B 1 678 ? 126.116 96.173  118.059 1.00 47.26  ? 670 TYR B CD2   1 
ATOM   9283  C  CE1   . TYR B 1 678 ? 127.807 98.343  118.181 1.00 45.80  ? 670 TYR B CE1   1 
ATOM   9284  C  CE2   . TYR B 1 678 ? 126.165 96.943  119.202 1.00 51.01  ? 670 TYR B CE2   1 
ATOM   9285  C  CZ    . TYR B 1 678 ? 127.013 98.026  119.257 1.00 49.82  ? 670 TYR B CZ    1 
ATOM   9286  O  OH    . TYR B 1 678 ? 127.066 98.797  120.393 1.00 53.05  ? 670 TYR B OH    1 
ATOM   9287  N  N     . ASP B 1 679 ? 127.203 92.674  114.730 1.00 51.94  ? 671 ASP B N     1 
ATOM   9288  C  CA    . ASP B 1 679 ? 126.823 91.626  113.793 1.00 55.44  ? 671 ASP B CA    1 
ATOM   9289  C  C     . ASP B 1 679 ? 125.473 91.980  113.185 1.00 52.90  ? 671 ASP B C     1 
ATOM   9290  O  O     . ASP B 1 679 ? 124.481 92.125  113.906 1.00 56.40  ? 671 ASP B O     1 
ATOM   9291  C  CB    . ASP B 1 679 ? 126.765 90.269  114.493 1.00 65.29  ? 671 ASP B CB    1 
ATOM   9292  C  CG    . ASP B 1 679 ? 126.762 89.106  113.518 1.00 69.70  ? 671 ASP B CG    1 
ATOM   9293  O  OD1   . ASP B 1 679 ? 126.240 89.258  112.395 1.00 65.38  ? 671 ASP B OD1   1 
ATOM   9294  O  OD2   . ASP B 1 679 ? 127.288 88.031  113.877 1.00 74.40  ? 671 ASP B OD2   1 
ATOM   9295  N  N     . ARG B 1 680 ? 125.433 92.106  111.858 1.00 51.89  ? 672 ARG B N     1 
ATOM   9296  C  CA    . ARG B 1 680 ? 124.216 92.521  111.172 1.00 55.06  ? 672 ARG B CA    1 
ATOM   9297  C  C     . ARG B 1 680 ? 123.156 91.430  111.115 1.00 58.90  ? 672 ARG B C     1 
ATOM   9298  O  O     . ARG B 1 680 ? 122.037 91.707  110.671 1.00 64.41  ? 672 ARG B O     1 
ATOM   9299  C  CB    . ARG B 1 680 ? 124.540 92.984  109.752 1.00 51.34  ? 672 ARG B CB    1 
ATOM   9300  C  CG    . ARG B 1 680 ? 125.158 94.364  109.669 1.00 48.81  ? 672 ARG B CG    1 
ATOM   9301  C  CD    . ARG B 1 680 ? 125.183 94.846  108.232 1.00 53.36  ? 672 ARG B CD    1 
ATOM   9302  N  NE    . ARG B 1 680 ? 123.889 94.656  107.588 1.00 62.14  ? 672 ARG B NE    1 
ATOM   9303  C  CZ    . ARG B 1 680 ? 123.627 94.959  106.324 1.00 65.39  ? 672 ARG B CZ    1 
ATOM   9304  N  NH1   . ARG B 1 680 ? 124.550 95.483  105.534 1.00 65.59  ? 672 ARG B NH1   1 
ATOM   9305  N  NH2   . ARG B 1 680 ? 122.410 94.731  105.841 1.00 63.47  ? 672 ARG B NH2   1 
ATOM   9306  N  N     . ARG B 1 681 ? 123.472 90.206  111.539 1.00 55.38  ? 673 ARG B N     1 
ATOM   9307  C  CA    . ARG B 1 681 ? 122.497 89.125  111.478 1.00 57.26  ? 673 ARG B CA    1 
ATOM   9308  C  C     . ARG B 1 681 ? 121.343 89.312  112.451 1.00 59.34  ? 673 ARG B C     1 
ATOM   9309  O  O     . ARG B 1 681 ? 120.325 88.626  112.312 1.00 59.27  ? 673 ARG B O     1 
ATOM   9310  C  CB    . ARG B 1 681 ? 123.180 87.785  111.749 1.00 62.50  ? 673 ARG B CB    1 
ATOM   9311  C  CG    . ARG B 1 681 ? 123.566 87.569  113.198 1.00 65.18  ? 673 ARG B CG    1 
ATOM   9312  C  CD    . ARG B 1 681 ? 124.299 86.254  113.374 1.00 69.42  ? 673 ARG B CD    1 
ATOM   9313  N  NE    . ARG B 1 681 ? 125.575 86.253  112.671 1.00 72.11  ? 673 ARG B NE    1 
ATOM   9314  C  CZ    . ARG B 1 681 ? 126.379 85.204  112.582 1.00 79.51  ? 673 ARG B CZ    1 
ATOM   9315  N  NH1   . ARG B 1 681 ? 126.063 84.043  113.132 1.00 83.96  ? 673 ARG B NH1   1 
ATOM   9316  N  NH2   . ARG B 1 681 ? 127.528 85.320  111.923 1.00 82.55  ? 673 ARG B NH2   1 
ATOM   9317  N  N     . PHE B 1 682 ? 121.469 90.213  113.422 1.00 63.50  ? 674 PHE B N     1 
ATOM   9318  C  CA    . PHE B 1 682 ? 120.432 90.448  114.418 1.00 63.79  ? 674 PHE B CA    1 
ATOM   9319  C  C     . PHE B 1 682 ? 119.624 91.676  114.021 1.00 61.60  ? 674 PHE B C     1 
ATOM   9320  O  O     . PHE B 1 682 ? 120.186 92.759  113.827 1.00 57.66  ? 674 PHE B O     1 
ATOM   9321  C  CB    . PHE B 1 682 ? 121.038 90.634  115.808 1.00 59.75  ? 674 PHE B CB    1 
ATOM   9322  C  CG    . PHE B 1 682 ? 121.822 89.451  116.290 1.00 57.85  ? 674 PHE B CG    1 
ATOM   9323  C  CD1   . PHE B 1 682 ? 121.176 88.314  116.740 1.00 61.90  ? 674 PHE B CD1   1 
ATOM   9324  C  CD2   . PHE B 1 682 ? 123.203 89.478  116.302 1.00 57.06  ? 674 PHE B CD2   1 
ATOM   9325  C  CE1   . PHE B 1 682 ? 121.893 87.224  117.187 1.00 66.78  ? 674 PHE B CE1   1 
ATOM   9326  C  CE2   . PHE B 1 682 ? 123.926 88.391  116.749 1.00 63.94  ? 674 PHE B CE2   1 
ATOM   9327  C  CZ    . PHE B 1 682 ? 123.269 87.263  117.191 1.00 67.14  ? 674 PHE B CZ    1 
ATOM   9328  N  N     . VAL B 1 683 ? 118.308 91.503  113.902 1.00 65.84  ? 675 VAL B N     1 
ATOM   9329  C  CA    . VAL B 1 683 ? 117.397 92.585  113.564 1.00 70.17  ? 675 VAL B CA    1 
ATOM   9330  C  C     . VAL B 1 683 ? 116.234 92.563  114.544 1.00 76.54  ? 675 VAL B C     1 
ATOM   9331  O  O     . VAL B 1 683 ? 115.895 91.528  115.122 1.00 82.25  ? 675 VAL B O     1 
ATOM   9332  C  CB    . VAL B 1 683 ? 116.882 92.486  112.112 1.00 71.93  ? 675 VAL B CB    1 
ATOM   9333  C  CG1   . VAL B 1 683 ? 118.004 92.778  111.129 1.00 68.01  ? 675 VAL B CG1   1 
ATOM   9334  C  CG2   . VAL B 1 683 ? 116.290 91.110  111.858 1.00 75.21  ? 675 VAL B CG2   1 
ATOM   9335  N  N     . GLY B 1 684 ? 115.619 93.724  114.723 1.00 74.77  ? 676 GLY B N     1 
ATOM   9336  C  CA    . GLY B 1 684 ? 114.503 93.828  115.651 1.00 81.30  ? 676 GLY B CA    1 
ATOM   9337  C  C     . GLY B 1 684 ? 114.987 94.128  117.051 1.00 83.24  ? 676 GLY B C     1 
ATOM   9338  O  O     . GLY B 1 684 ? 115.715 95.096  117.275 1.00 82.07  ? 676 GLY B O     1 
ATOM   9339  N  N     . PHE B 1 685 ? 114.576 93.295  118.005 1.00 85.93  ? 677 PHE B N     1 
ATOM   9340  C  CA    . PHE B 1 685 ? 114.921 93.474  119.407 1.00 86.95  ? 677 PHE B CA    1 
ATOM   9341  C  C     . PHE B 1 685 ? 115.428 92.163  119.989 1.00 84.04  ? 677 PHE B C     1 
ATOM   9342  O  O     . PHE B 1 685 ? 114.861 91.098  119.729 1.00 86.71  ? 677 PHE B O     1 
ATOM   9343  C  CB    . PHE B 1 685 ? 113.713 93.975  120.210 1.00 91.26  ? 677 PHE B CB    1 
ATOM   9344  C  CG    . PHE B 1 685 ? 113.850 93.789  121.693 1.00 96.61  ? 677 PHE B CG    1 
ATOM   9345  C  CD1   . PHE B 1 685 ? 114.733 94.565  122.424 1.00 98.71  ? 677 PHE B CD1   1 
ATOM   9346  C  CD2   . PHE B 1 685 ? 113.088 92.842  122.358 1.00 96.03  ? 677 PHE B CD2   1 
ATOM   9347  C  CE1   . PHE B 1 685 ? 114.860 94.396  123.789 1.00 96.87  ? 677 PHE B CE1   1 
ATOM   9348  C  CE2   . PHE B 1 685 ? 113.209 92.668  123.723 1.00 97.17  ? 677 PHE B CE2   1 
ATOM   9349  C  CZ    . PHE B 1 685 ? 114.096 93.447  124.440 1.00 97.99  ? 677 PHE B CZ    1 
ATOM   9350  N  N     . GLY B 1 686 ? 116.497 92.247  120.775 1.00 77.19  ? 678 GLY B N     1 
ATOM   9351  C  CA    . GLY B 1 686 ? 116.996 91.055  121.462 1.00 76.25  ? 678 GLY B CA    1 
ATOM   9352  C  C     . GLY B 1 686 ? 118.371 90.638  120.980 1.00 74.28  ? 678 GLY B C     1 
ATOM   9353  O  O     . GLY B 1 686 ? 118.622 90.476  119.786 1.00 77.37  ? 678 GLY B O     1 
ATOM   9354  N  N     . TRP B 1 687 ? 119.281 90.469  121.938 1.00 69.07  ? 679 TRP B N     1 
ATOM   9355  C  CA    . TRP B 1 687 ? 120.640 89.979  121.721 1.00 62.89  ? 679 TRP B CA    1 
ATOM   9356  C  C     . TRP B 1 687 ? 121.466 90.882  120.815 1.00 61.71  ? 679 TRP B C     1 
ATOM   9357  O  O     . TRP B 1 687 ? 122.501 90.448  120.297 1.00 64.99  ? 679 TRP B O     1 
ATOM   9358  C  CB    . TRP B 1 687 ? 120.636 88.552  121.160 1.00 65.00  ? 679 TRP B CB    1 
ATOM   9359  C  CG    . TRP B 1 687 ? 120.974 87.514  122.173 1.00 69.37  ? 679 TRP B CG    1 
ATOM   9360  C  CD1   . TRP B 1 687 ? 120.126 86.936  123.070 1.00 74.13  ? 679 TRP B CD1   1 
ATOM   9361  C  CD2   . TRP B 1 687 ? 122.257 86.924  122.395 1.00 73.21  ? 679 TRP B CD2   1 
ATOM   9362  N  NE1   . TRP B 1 687 ? 120.803 86.023  123.839 1.00 79.08  ? 679 TRP B NE1   1 
ATOM   9363  C  CE2   . TRP B 1 687 ? 122.115 85.997  123.444 1.00 81.24  ? 679 TRP B CE2   1 
ATOM   9364  C  CE3   . TRP B 1 687 ? 123.515 87.091  121.808 1.00 71.01  ? 679 TRP B CE3   1 
ATOM   9365  C  CZ2   . TRP B 1 687 ? 123.181 85.240  123.919 1.00 86.30  ? 679 TRP B CZ2   1 
ATOM   9366  C  CZ3   . TRP B 1 687 ? 124.570 86.338  122.280 1.00 76.22  ? 679 TRP B CZ3   1 
ATOM   9367  C  CH2   . TRP B 1 687 ? 124.397 85.423  123.324 1.00 84.74  ? 679 TRP B CH2   1 
ATOM   9368  N  N     . ASN B 1 688 ? 121.041 92.128  120.607 1.00 61.44  ? 680 ASN B N     1 
ATOM   9369  C  CA    . ASN B 1 688 ? 121.769 93.014  119.705 1.00 55.16  ? 680 ASN B CA    1 
ATOM   9370  C  C     . ASN B 1 688 ? 123.108 93.434  120.301 1.00 55.26  ? 680 ASN B C     1 
ATOM   9371  O  O     . ASN B 1 688 ? 124.147 93.351  119.638 1.00 56.27  ? 680 ASN B O     1 
ATOM   9372  C  CB    . ASN B 1 688 ? 120.912 94.235  119.378 1.00 57.15  ? 680 ASN B CB    1 
ATOM   9373  C  CG    . ASN B 1 688 ? 119.511 93.860  118.950 1.00 63.24  ? 680 ASN B CG    1 
ATOM   9374  O  OD1   . ASN B 1 688 ? 118.529 94.297  119.549 1.00 63.52  ? 680 ASN B OD1   1 
ATOM   9375  N  ND2   . ASN B 1 688 ? 119.409 93.040  117.913 1.00 68.12  ? 680 ASN B ND2   1 
ATOM   9376  N  N     . LYS B 1 689 ? 123.104 93.885  121.557 1.00 55.24  ? 681 LYS B N     1 
ATOM   9377  C  CA    . LYS B 1 689 ? 124.334 94.325  122.204 1.00 52.97  ? 681 LYS B CA    1 
ATOM   9378  C  C     . LYS B 1 689 ? 125.079 93.189  122.889 1.00 54.65  ? 681 LYS B C     1 
ATOM   9379  O  O     . LYS B 1 689 ? 126.281 93.322  123.146 1.00 56.84  ? 681 LYS B O     1 
ATOM   9380  C  CB    . LYS B 1 689 ? 124.027 95.422  123.224 1.00 49.57  ? 681 LYS B CB    1 
ATOM   9381  C  CG    . LYS B 1 689 ? 123.531 96.715  122.610 1.00 52.35  ? 681 LYS B CG    1 
ATOM   9382  C  CD    . LYS B 1 689 ? 123.067 97.692  123.677 1.00 56.70  ? 681 LYS B CD    1 
ATOM   9383  C  CE    . LYS B 1 689 ? 121.848 97.163  124.414 1.00 58.53  ? 681 LYS B CE    1 
ATOM   9384  N  NZ    . LYS B 1 689 ? 121.303 98.155  125.380 1.00 55.58  ? 681 LYS B NZ    1 
ATOM   9385  N  N     . VAL B 1 690 ? 124.395 92.085  123.192 1.00 55.67  ? 682 VAL B N     1 
ATOM   9386  C  CA    . VAL B 1 690 ? 125.052 90.958  123.847 1.00 62.01  ? 682 VAL B CA    1 
ATOM   9387  C  C     . VAL B 1 690 ? 126.146 90.392  122.953 1.00 63.28  ? 682 VAL B C     1 
ATOM   9388  O  O     . VAL B 1 690 ? 127.252 90.085  123.415 1.00 64.64  ? 682 VAL B O     1 
ATOM   9389  C  CB    . VAL B 1 690 ? 124.018 89.883  124.225 1.00 64.60  ? 682 VAL B CB    1 
ATOM   9390  C  CG1   . VAL B 1 690 ? 124.683 88.757  125.000 1.00 65.49  ? 682 VAL B CG1   1 
ATOM   9391  C  CG2   . VAL B 1 690 ? 122.884 90.496  125.030 1.00 58.17  ? 682 VAL B CG2   1 
ATOM   9392  N  N     . ALA B 1 691 ? 125.854 90.246  121.658 1.00 58.52  ? 683 ALA B N     1 
ATOM   9393  C  CA    . ALA B 1 691 ? 126.849 89.729  120.725 1.00 59.11  ? 683 ALA B CA    1 
ATOM   9394  C  C     . ALA B 1 691 ? 128.055 90.655  120.632 1.00 58.61  ? 683 ALA B C     1 
ATOM   9395  O  O     . ALA B 1 691 ? 129.201 90.193  120.603 1.00 64.95  ? 683 ALA B O     1 
ATOM   9396  C  CB    . ALA B 1 691 ? 126.215 89.528  119.350 1.00 62.74  ? 683 ALA B CB    1 
ATOM   9397  N  N     . HIS B 1 692 ? 127.818 91.967  120.582 1.00 56.71  ? 684 HIS B N     1 
ATOM   9398  C  CA    . HIS B 1 692 ? 128.929 92.909  120.501 1.00 56.51  ? 684 HIS B CA    1 
ATOM   9399  C  C     . HIS B 1 692 ? 129.779 92.875  121.765 1.00 55.46  ? 684 HIS B C     1 
ATOM   9400  O  O     . HIS B 1 692 ? 131.010 92.949  121.692 1.00 55.64  ? 684 HIS B O     1 
ATOM   9401  C  CB    . HIS B 1 692 ? 128.407 94.321  120.242 1.00 50.22  ? 684 HIS B CB    1 
ATOM   9402  C  CG    . HIS B 1 692 ? 129.490 95.340  120.077 1.00 47.98  ? 684 HIS B CG    1 
ATOM   9403  N  ND1   . HIS B 1 692 ? 129.781 96.279  121.042 1.00 47.37  ? 684 HIS B ND1   1 
ATOM   9404  C  CD2   . HIS B 1 692 ? 130.358 95.561  119.063 1.00 48.13  ? 684 HIS B CD2   1 
ATOM   9405  C  CE1   . HIS B 1 692 ? 130.779 97.038  120.628 1.00 47.56  ? 684 HIS B CE1   1 
ATOM   9406  N  NE2   . HIS B 1 692 ? 131.147 96.623  119.429 1.00 48.86  ? 684 HIS B NE2   1 
ATOM   9407  N  N     . ILE B 1 693 ? 129.144 92.760  122.933 1.00 55.01  ? 685 ILE B N     1 
ATOM   9408  C  CA    . ILE B 1 693 ? 129.908 92.691  124.175 1.00 55.03  ? 685 ILE B CA    1 
ATOM   9409  C  C     . ILE B 1 693 ? 130.709 91.396  124.238 1.00 62.19  ? 685 ILE B C     1 
ATOM   9410  O  O     . ILE B 1 693 ? 131.852 91.379  124.711 1.00 65.71  ? 685 ILE B O     1 
ATOM   9411  C  CB    . ILE B 1 693 ? 128.974 92.849  125.387 1.00 54.60  ? 685 ILE B CB    1 
ATOM   9412  C  CG1   . ILE B 1 693 ? 128.326 94.233  125.374 1.00 49.39  ? 685 ILE B CG1   1 
ATOM   9413  C  CG2   . ILE B 1 693 ? 129.738 92.644  126.684 1.00 56.41  ? 685 ILE B CG2   1 
ATOM   9414  C  CD1   . ILE B 1 693 ? 129.320 95.370  125.356 1.00 44.54  ? 685 ILE B CD1   1 
ATOM   9415  N  N     . MET B 1 694 ? 130.130 90.292  123.759 1.00 63.38  ? 686 MET B N     1 
ATOM   9416  C  CA    . MET B 1 694 ? 130.872 89.036  123.703 1.00 63.87  ? 686 MET B CA    1 
ATOM   9417  C  C     . MET B 1 694 ? 132.076 89.150  122.777 1.00 63.94  ? 686 MET B C     1 
ATOM   9418  O  O     . MET B 1 694 ? 133.165 88.662  123.100 1.00 68.04  ? 686 MET B O     1 
ATOM   9419  C  CB    . MET B 1 694 ? 129.955 87.902  123.250 1.00 65.25  ? 686 MET B CB    1 
ATOM   9420  C  CG    . MET B 1 694 ? 128.944 87.472  124.294 1.00 72.34  ? 686 MET B CG    1 
ATOM   9421  S  SD    . MET B 1 694 ? 127.729 86.316  123.641 1.00 83.97  ? 686 MET B SD    1 
ATOM   9422  C  CE    . MET B 1 694 ? 128.793 85.069  122.925 1.00 82.62  ? 686 MET B CE    1 
ATOM   9423  N  N     . GLU B 1 695 ? 131.899 89.790  121.620 1.00 63.53  ? 687 GLU B N     1 
ATOM   9424  C  CA    . GLU B 1 695 ? 133.020 89.985  120.706 1.00 65.61  ? 687 GLU B CA    1 
ATOM   9425  C  C     . GLU B 1 695 ? 134.086 90.879  121.324 1.00 63.58  ? 687 GLU B C     1 
ATOM   9426  O  O     . GLU B 1 695 ? 135.284 90.674  121.101 1.00 67.84  ? 687 GLU B O     1 
ATOM   9427  C  CB    . GLU B 1 695 ? 132.527 90.568  119.383 1.00 65.97  ? 687 GLU B CB    1 
ATOM   9428  C  CG    . GLU B 1 695 ? 131.983 89.533  118.410 1.00 71.35  ? 687 GLU B CG    1 
ATOM   9429  C  CD    . GLU B 1 695 ? 133.082 88.757  117.705 1.00 81.59  ? 687 GLU B CD    1 
ATOM   9430  O  OE1   . GLU B 1 695 ? 134.270 89.095  117.893 1.00 82.29  ? 687 GLU B OE1   1 
ATOM   9431  O  OE2   . GLU B 1 695 ? 132.757 87.811  116.956 1.00 86.26  ? 687 GLU B OE2   1 
ATOM   9432  N  N     . LEU B 1 696 ? 133.670 91.889  122.089 1.00 61.62  ? 688 LEU B N     1 
ATOM   9433  C  CA    . LEU B 1 696 ? 134.638 92.719  122.798 1.00 61.58  ? 688 LEU B CA    1 
ATOM   9434  C  C     . LEU B 1 696 ? 135.424 91.898  123.811 1.00 63.16  ? 688 LEU B C     1 
ATOM   9435  O  O     . LEU B 1 696 ? 136.649 92.026  123.910 1.00 66.76  ? 688 LEU B O     1 
ATOM   9436  C  CB    . LEU B 1 696 ? 133.929 93.879  123.495 1.00 59.26  ? 688 LEU B CB    1 
ATOM   9437  C  CG    . LEU B 1 696 ? 133.364 94.999  122.625 1.00 54.02  ? 688 LEU B CG    1 
ATOM   9438  C  CD1   . LEU B 1 696 ? 132.606 95.989  123.487 1.00 48.69  ? 688 LEU B CD1   1 
ATOM   9439  C  CD2   . LEU B 1 696 ? 134.479 95.695  121.868 1.00 59.76  ? 688 LEU B CD2   1 
ATOM   9440  N  N     . ASP B 1 697 ? 134.734 91.046  124.570 1.00 63.87  ? 689 ASP B N     1 
ATOM   9441  C  CA    . ASP B 1 697 ? 135.413 90.256  125.592 1.00 65.28  ? 689 ASP B CA    1 
ATOM   9442  C  C     . ASP B 1 697 ? 136.365 89.240  124.973 1.00 70.83  ? 689 ASP B C     1 
ATOM   9443  O  O     . ASP B 1 697 ? 137.462 89.013  125.495 1.00 73.56  ? 689 ASP B O     1 
ATOM   9444  C  CB    . ASP B 1 697 ? 134.394 89.555  126.485 1.00 68.64  ? 689 ASP B CB    1 
ATOM   9445  C  CG    . ASP B 1 697 ? 135.049 88.766  127.601 1.00 79.17  ? 689 ASP B CG    1 
ATOM   9446  O  OD1   . ASP B 1 697 ? 135.604 89.394  128.528 1.00 81.53  ? 689 ASP B OD1   1 
ATOM   9447  O  OD2   . ASP B 1 697 ? 135.017 87.520  127.550 1.00 79.70  ? 689 ASP B OD2   1 
ATOM   9448  N  N     . VAL B 1 698 ? 135.965 88.615  123.862 1.00 68.06  ? 690 VAL B N     1 
ATOM   9449  C  CA    . VAL B 1 698 ? 136.808 87.600  123.244 1.00 63.79  ? 690 VAL B CA    1 
ATOM   9450  C  C     . VAL B 1 698 ? 138.063 88.205  122.629 1.00 62.69  ? 690 VAL B C     1 
ATOM   9451  O  O     . VAL B 1 698 ? 139.030 87.482  122.368 1.00 67.49  ? 690 VAL B O     1 
ATOM   9452  C  CB    . VAL B 1 698 ? 136.009 86.803  122.194 1.00 67.40  ? 690 VAL B CB    1 
ATOM   9453  C  CG1   . VAL B 1 698 ? 135.937 87.560  120.881 1.00 68.58  ? 690 VAL B CG1   1 
ATOM   9454  C  CG2   . VAL B 1 698 ? 136.616 85.425  121.993 1.00 79.55  ? 690 VAL B CG2   1 
ATOM   9455  N  N     . GLN B 1 699 ? 138.081 89.518  122.396 1.00 61.39  ? 691 GLN B N     1 
ATOM   9456  C  CA    . GLN B 1 699 ? 139.256 90.205  121.881 1.00 64.44  ? 691 GLN B CA    1 
ATOM   9457  C  C     . GLN B 1 699 ? 140.074 90.858  122.988 1.00 64.37  ? 691 GLN B C     1 
ATOM   9458  O  O     . GLN B 1 699 ? 140.841 91.789  122.717 1.00 63.72  ? 691 GLN B O     1 
ATOM   9459  C  CB    . GLN B 1 699 ? 138.852 91.248  120.839 1.00 64.95  ? 691 GLN B CB    1 
ATOM   9460  C  CG    . GLN B 1 699 ? 138.212 90.662  119.595 1.00 68.33  ? 691 GLN B CG    1 
ATOM   9461  C  CD    . GLN B 1 699 ? 138.138 91.658  118.458 1.00 71.12  ? 691 GLN B CD    1 
ATOM   9462  O  OE1   . GLN B 1 699 ? 138.803 92.692  118.479 1.00 70.48  ? 691 GLN B OE1   1 
ATOM   9463  N  NE2   . GLN B 1 699 ? 137.326 91.349  117.454 1.00 76.56  ? 691 GLN B NE2   1 
ATOM   9464  N  N     . GLU B 1 700 ? 139.914 90.393  124.226 1.00 63.21  ? 692 GLU B N     1 
ATOM   9465  C  CA    . GLU B 1 700 ? 140.675 90.880  125.375 1.00 66.56  ? 692 GLU B CA    1 
ATOM   9466  C  C     . GLU B 1 700 ? 140.456 92.379  125.589 1.00 65.51  ? 692 GLU B C     1 
ATOM   9467  O  O     . GLU B 1 700 ? 141.384 93.188  125.544 1.00 68.32  ? 692 GLU B O     1 
ATOM   9468  C  CB    . GLU B 1 700 ? 142.165 90.553  125.226 1.00 73.38  ? 692 GLU B CB    1 
ATOM   9469  C  CG    . GLU B 1 700 ? 142.467 89.066  125.171 1.00 78.14  ? 692 GLU B CG    1 
ATOM   9470  C  CD    . GLU B 1 700 ? 143.952 88.777  125.092 1.00 85.64  ? 692 GLU B CD    1 
ATOM   9471  O  OE1   . GLU B 1 700 ? 144.746 89.741  125.085 1.00 87.13  ? 692 GLU B OE1   1 
ATOM   9472  O  OE2   . GLU B 1 700 ? 144.327 87.587  125.038 1.00 90.80  ? 692 GLU B OE2   1 
ATOM   9473  N  N     . TYR B 1 701 ? 139.197 92.736  125.819 1.00 63.97  ? 693 TYR B N     1 
ATOM   9474  C  CA    . TYR B 1 701 ? 138.826 94.083  126.225 1.00 64.63  ? 693 TYR B CA    1 
ATOM   9475  C  C     . TYR B 1 701 ? 138.512 94.093  127.714 1.00 64.67  ? 693 TYR B C     1 
ATOM   9476  O  O     . TYR B 1 701 ? 137.778 93.233  128.210 1.00 61.52  ? 693 TYR B O     1 
ATOM   9477  C  CB    . TYR B 1 701 ? 137.619 94.594  125.436 1.00 63.57  ? 693 TYR B CB    1 
ATOM   9478  C  CG    . TYR B 1 701 ? 137.969 95.304  124.147 1.00 62.37  ? 693 TYR B CG    1 
ATOM   9479  C  CD1   . TYR B 1 701 ? 138.441 96.609  124.159 1.00 64.13  ? 693 TYR B CD1   1 
ATOM   9480  C  CD2   . TYR B 1 701 ? 137.814 94.676  122.920 1.00 61.86  ? 693 TYR B CD2   1 
ATOM   9481  C  CE1   . TYR B 1 701 ? 138.759 97.264  122.986 1.00 67.80  ? 693 TYR B CE1   1 
ATOM   9482  C  CE2   . TYR B 1 701 ? 138.129 95.323  121.743 1.00 64.91  ? 693 TYR B CE2   1 
ATOM   9483  C  CZ    . TYR B 1 701 ? 138.601 96.617  121.782 1.00 68.82  ? 693 TYR B CZ    1 
ATOM   9484  O  OH    . TYR B 1 701 ? 138.915 97.266  120.612 1.00 69.95  ? 693 TYR B OH    1 
ATOM   9485  N  N     . GLU B 1 702 ? 139.077 95.065  128.423 1.00 68.23  ? 694 GLU B N     1 
ATOM   9486  C  CA    . GLU B 1 702 ? 138.862 95.200  129.857 1.00 67.19  ? 694 GLU B CA    1 
ATOM   9487  C  C     . GLU B 1 702 ? 137.660 96.103  130.100 1.00 62.97  ? 694 GLU B C     1 
ATOM   9488  O  O     . GLU B 1 702 ? 137.638 97.252  129.646 1.00 64.54  ? 694 GLU B O     1 
ATOM   9489  C  CB    . GLU B 1 702 ? 140.104 95.767  130.543 1.00 70.24  ? 694 GLU B CB    1 
ATOM   9490  C  CG    . GLU B 1 702 ? 141.337 94.890  130.427 1.00 77.31  ? 694 GLU B CG    1 
ATOM   9491  C  CD    . GLU B 1 702 ? 142.498 95.412  131.248 1.00 85.95  ? 694 GLU B CD    1 
ATOM   9492  O  OE1   . GLU B 1 702 ? 142.269 96.286  132.112 1.00 83.49  ? 694 GLU B OE1   1 
ATOM   9493  O  OE2   . GLU B 1 702 ? 143.638 94.952  131.030 1.00 88.55  ? 694 GLU B OE2   1 
ATOM   9494  N  N     . PHE B 1 703 ? 136.667 95.585  130.815 1.00 55.12  ? 695 PHE B N     1 
ATOM   9495  C  CA    . PHE B 1 703 ? 135.483 96.365  131.149 1.00 51.78  ? 695 PHE B CA    1 
ATOM   9496  C  C     . PHE B 1 703 ? 135.758 97.180  132.405 1.00 54.17  ? 695 PHE B C     1 
ATOM   9497  O  O     . PHE B 1 703 ? 136.019 96.618  133.473 1.00 59.73  ? 695 PHE B O     1 
ATOM   9498  C  CB    . PHE B 1 703 ? 134.279 95.449  131.344 1.00 49.48  ? 695 PHE B CB    1 
ATOM   9499  C  CG    . PHE B 1 703 ? 133.936 94.634  130.131 1.00 48.37  ? 695 PHE B CG    1 
ATOM   9500  C  CD1   . PHE B 1 703 ? 133.453 95.243  128.986 1.00 48.01  ? 695 PHE B CD1   1 
ATOM   9501  C  CD2   . PHE B 1 703 ? 134.088 93.259  130.139 1.00 49.31  ? 695 PHE B CD2   1 
ATOM   9502  C  CE1   . PHE B 1 703 ? 133.135 94.496  127.870 1.00 46.74  ? 695 PHE B CE1   1 
ATOM   9503  C  CE2   . PHE B 1 703 ? 133.770 92.507  129.027 1.00 54.93  ? 695 PHE B CE2   1 
ATOM   9504  C  CZ    . PHE B 1 703 ? 133.293 93.126  127.891 1.00 54.05  ? 695 PHE B CZ    1 
ATOM   9505  N  N     . ILE B 1 704 ? 135.710 98.503  132.275 1.00 54.79  ? 696 ILE B N     1 
ATOM   9506  C  CA    . ILE B 1 704 ? 136.009 99.424  133.364 1.00 54.10  ? 696 ILE B CA    1 
ATOM   9507  C  C     . ILE B 1 704 ? 134.770 100.263 133.636 1.00 56.30  ? 696 ILE B C     1 
ATOM   9508  O  O     . ILE B 1 704 ? 134.202 100.855 132.712 1.00 62.89  ? 696 ILE B O     1 
ATOM   9509  C  CB    . ILE B 1 704 ? 137.209 100.329 133.028 1.00 55.09  ? 696 ILE B CB    1 
ATOM   9510  C  CG1   . ILE B 1 704 ? 138.374 99.499  132.490 1.00 57.36  ? 696 ILE B CG1   1 
ATOM   9511  C  CG2   . ILE B 1 704 ? 137.638 101.117 134.250 1.00 56.81  ? 696 ILE B CG2   1 
ATOM   9512  C  CD1   . ILE B 1 704 ? 138.897 98.480  133.467 1.00 62.40  ? 696 ILE B CD1   1 
ATOM   9513  N  N     . VAL B 1 705 ? 134.357 100.317 134.898 1.00 52.66  ? 697 VAL B N     1 
ATOM   9514  C  CA    . VAL B 1 705 ? 133.231 101.134 135.328 1.00 54.09  ? 697 VAL B CA    1 
ATOM   9515  C  C     . VAL B 1 705 ? 133.775 102.397 135.975 1.00 58.14  ? 697 VAL B C     1 
ATOM   9516  O  O     . VAL B 1 705 ? 134.627 102.331 136.874 1.00 63.47  ? 697 VAL B O     1 
ATOM   9517  C  CB    . VAL B 1 705 ? 132.320 100.365 136.297 1.00 55.14  ? 697 VAL B CB    1 
ATOM   9518  C  CG1   . VAL B 1 705 ? 131.139 101.227 136.705 1.00 57.32  ? 697 VAL B CG1   1 
ATOM   9519  C  CG2   . VAL B 1 705 ? 131.846 99.072  135.661 1.00 55.36  ? 697 VAL B CG2   1 
ATOM   9520  N  N     . LEU B 1 706 ? 133.301 103.549 135.500 1.00 57.06  ? 698 LEU B N     1 
ATOM   9521  C  CA    . LEU B 1 706 ? 133.689 104.846 136.033 1.00 63.47  ? 698 LEU B CA    1 
ATOM   9522  C  C     . LEU B 1 706 ? 132.823 105.195 137.243 1.00 70.39  ? 698 LEU B C     1 
ATOM   9523  O  O     . LEU B 1 706 ? 131.631 104.879 137.266 1.00 71.43  ? 698 LEU B O     1 
ATOM   9524  C  CB    . LEU B 1 706 ? 133.549 105.927 134.964 1.00 62.67  ? 698 LEU B CB    1 
ATOM   9525  C  CG    . LEU B 1 706 ? 134.306 105.687 133.656 1.00 61.11  ? 698 LEU B CG    1 
ATOM   9526  C  CD1   . LEU B 1 706 ? 134.061 106.822 132.678 1.00 60.13  ? 698 LEU B CD1   1 
ATOM   9527  C  CD2   . LEU B 1 706 ? 135.793 105.518 133.916 1.00 66.68  ? 698 LEU B CD2   1 
ATOM   9528  N  N     . PRO B 1 707 ? 133.394 105.842 138.257 1.00 70.02  ? 699 PRO B N     1 
ATOM   9529  C  CA    . PRO B 1 707 ? 132.627 106.118 139.479 1.00 66.83  ? 699 PRO B CA    1 
ATOM   9530  C  C     . PRO B 1 707 ? 131.594 107.224 139.323 1.00 65.67  ? 699 PRO B C     1 
ATOM   9531  O  O     . PRO B 1 707 ? 130.460 107.085 139.791 1.00 68.08  ? 699 PRO B O     1 
ATOM   9532  C  CB    . PRO B 1 707 ? 133.716 106.512 140.484 1.00 68.76  ? 699 PRO B CB    1 
ATOM   9533  C  CG    . PRO B 1 707 ? 134.803 107.083 139.643 1.00 69.76  ? 699 PRO B CG    1 
ATOM   9534  C  CD    . PRO B 1 707 ? 134.790 106.303 138.359 1.00 67.56  ? 699 PRO B CD    1 
ATOM   9535  N  N     . ASN B 1 708 ? 131.967 108.322 138.662 1.00 62.72  ? 700 ASN B N     1 
ATOM   9536  C  CA    . ASN B 1 708 ? 131.152 109.530 138.622 1.00 64.08  ? 700 ASN B CA    1 
ATOM   9537  C  C     . ASN B 1 708 ? 130.447 109.726 137.284 1.00 63.78  ? 700 ASN B C     1 
ATOM   9538  O  O     . ASN B 1 708 ? 130.336 110.858 136.804 1.00 66.04  ? 700 ASN B O     1 
ATOM   9539  C  CB    . ASN B 1 708 ? 132.008 110.753 138.949 1.00 66.94  ? 700 ASN B CB    1 
ATOM   9540  C  CG    . ASN B 1 708 ? 132.554 110.720 140.360 1.00 73.35  ? 700 ASN B CG    1 
ATOM   9541  O  OD1   . ASN B 1 708 ? 131.938 110.154 141.262 1.00 71.10  ? 700 ASN B OD1   1 
ATOM   9542  N  ND2   . ASN B 1 708 ? 133.715 111.332 140.560 1.00 76.20  ? 700 ASN B ND2   1 
ATOM   9543  N  N     . ALA B 1 709 ? 129.970 108.648 136.669 1.00 64.41  ? 701 ALA B N     1 
ATOM   9544  C  CA    . ALA B 1 709 ? 129.235 108.729 135.416 1.00 59.29  ? 701 ALA B CA    1 
ATOM   9545  C  C     . ALA B 1 709 ? 127.957 107.912 135.525 1.00 56.44  ? 701 ALA B C     1 
ATOM   9546  O  O     . ALA B 1 709 ? 127.924 106.877 136.194 1.00 58.71  ? 701 ALA B O     1 
ATOM   9547  C  CB    . ALA B 1 709 ? 130.075 108.230 134.235 1.00 57.70  ? 701 ALA B CB    1 
ATOM   9548  N  N     . TYR B 1 710 ? 126.902 108.392 134.872 1.00 54.97  ? 702 TYR B N     1 
ATOM   9549  C  CA    . TYR B 1 710 ? 125.631 107.680 134.874 1.00 56.28  ? 702 TYR B CA    1 
ATOM   9550  C  C     . TYR B 1 710 ? 124.774 108.174 133.719 1.00 53.01  ? 702 TYR B C     1 
ATOM   9551  O  O     . TYR B 1 710 ? 124.999 109.254 133.168 1.00 48.09  ? 702 TYR B O     1 
ATOM   9552  C  CB    . TYR B 1 710 ? 124.890 107.848 136.206 1.00 53.16  ? 702 TYR B CB    1 
ATOM   9553  C  CG    . TYR B 1 710 ? 124.653 109.286 136.606 1.00 52.21  ? 702 TYR B CG    1 
ATOM   9554  C  CD1   . TYR B 1 710 ? 125.623 110.005 137.288 1.00 53.96  ? 702 TYR B CD1   1 
ATOM   9555  C  CD2   . TYR B 1 710 ? 123.456 109.921 136.309 1.00 52.91  ? 702 TYR B CD2   1 
ATOM   9556  C  CE1   . TYR B 1 710 ? 125.413 111.316 137.656 1.00 55.80  ? 702 TYR B CE1   1 
ATOM   9557  C  CE2   . TYR B 1 710 ? 123.236 111.232 136.674 1.00 56.90  ? 702 TYR B CE2   1 
ATOM   9558  C  CZ    . TYR B 1 710 ? 124.218 111.925 137.347 1.00 59.20  ? 702 TYR B CZ    1 
ATOM   9559  O  OH    . TYR B 1 710 ? 124.006 113.232 137.713 1.00 65.09  ? 702 TYR B OH    1 
ATOM   9560  N  N     . MET B 1 711 ? 123.785 107.358 133.364 1.00 53.69  ? 703 MET B N     1 
ATOM   9561  C  CA    . MET B 1 711 ? 122.823 107.692 132.326 1.00 48.71  ? 703 MET B CA    1 
ATOM   9562  C  C     . MET B 1 711 ? 121.490 107.060 132.692 1.00 52.43  ? 703 MET B C     1 
ATOM   9563  O  O     . MET B 1 711 ? 121.444 105.971 133.270 1.00 58.18  ? 703 MET B O     1 
ATOM   9564  C  CB    . MET B 1 711 ? 123.296 107.214 130.949 1.00 48.96  ? 703 MET B CB    1 
ATOM   9565  C  CG    . MET B 1 711 ? 123.433 105.707 130.826 1.00 52.38  ? 703 MET B CG    1 
ATOM   9566  S  SD    . MET B 1 711 ? 124.485 105.222 129.448 1.00 67.45  ? 703 MET B SD    1 
ATOM   9567  C  CE    . MET B 1 711 ? 123.947 106.386 128.203 1.00 54.56  ? 703 MET B CE    1 
ATOM   9568  N  N     . ILE B 1 712 ? 120.403 107.750 132.357 1.00 47.88  ? 704 ILE B N     1 
ATOM   9569  C  CA    . ILE B 1 712 ? 119.065 107.354 132.780 1.00 48.13  ? 704 ILE B CA    1 
ATOM   9570  C  C     . ILE B 1 712 ? 118.235 107.016 131.550 1.00 46.58  ? 704 ILE B C     1 
ATOM   9571  O  O     . ILE B 1 712 ? 118.133 107.826 130.624 1.00 49.93  ? 704 ILE B O     1 
ATOM   9572  C  CB    . ILE B 1 712 ? 118.387 108.456 133.613 1.00 47.14  ? 704 ILE B CB    1 
ATOM   9573  C  CG1   . ILE B 1 712 ? 119.283 108.851 134.787 1.00 46.43  ? 704 ILE B CG1   1 
ATOM   9574  C  CG2   . ILE B 1 712 ? 117.032 107.985 134.110 1.00 50.82  ? 704 ILE B CG2   1 
ATOM   9575  C  CD1   . ILE B 1 712 ? 118.687 109.904 135.684 1.00 54.12  ? 704 ILE B CD1   1 
ATOM   9576  N  N     . HIS B 1 713 ? 117.638 105.826 131.548 1.00 46.46  ? 705 HIS B N     1 
ATOM   9577  C  CA    . HIS B 1 713 ? 116.826 105.356 130.426 1.00 45.46  ? 705 HIS B CA    1 
ATOM   9578  C  C     . HIS B 1 713 ? 115.410 105.891 130.592 1.00 53.89  ? 705 HIS B C     1 
ATOM   9579  O  O     . HIS B 1 713 ? 114.629 105.374 131.393 1.00 60.37  ? 705 HIS B O     1 
ATOM   9580  C  CB    . HIS B 1 713 ? 116.836 103.834 130.356 1.00 48.10  ? 705 HIS B CB    1 
ATOM   9581  C  CG    . HIS B 1 713 ? 115.853 103.266 129.381 1.00 51.11  ? 705 HIS B CG    1 
ATOM   9582  N  ND1   . HIS B 1 713 ? 114.574 102.903 129.740 1.00 58.44  ? 705 HIS B ND1   1 
ATOM   9583  C  CD2   . HIS B 1 713 ? 115.964 102.993 128.060 1.00 52.22  ? 705 HIS B CD2   1 
ATOM   9584  C  CE1   . HIS B 1 713 ? 113.938 102.433 128.682 1.00 55.79  ? 705 HIS B CE1   1 
ATOM   9585  N  NE2   . HIS B 1 713 ? 114.759 102.477 127.649 1.00 53.73  ? 705 HIS B NE2   1 
ATOM   9586  N  N     . MET B 1 714 ? 115.077 106.927 129.831 1.00 55.44  ? 706 MET B N     1 
ATOM   9587  C  CA    . MET B 1 714 ? 113.735 107.482 129.887 1.00 58.92  ? 706 MET B CA    1 
ATOM   9588  C  C     . MET B 1 714 ? 112.735 106.491 129.298 1.00 62.55  ? 706 MET B C     1 
ATOM   9589  O  O     . MET B 1 714 ? 113.005 105.875 128.262 1.00 62.27  ? 706 MET B O     1 
ATOM   9590  C  CB    . MET B 1 714 ? 113.670 108.806 129.131 1.00 55.11  ? 706 MET B CB    1 
ATOM   9591  C  CG    . MET B 1 714 ? 114.744 109.795 129.542 1.00 52.86  ? 706 MET B CG    1 
ATOM   9592  S  SD    . MET B 1 714 ? 114.813 110.050 131.324 1.00 57.38  ? 706 MET B SD    1 
ATOM   9593  C  CE    . MET B 1 714 ? 113.173 110.691 131.643 1.00 67.10  ? 706 MET B CE    1 
ATOM   9594  N  N     . PRO B 1 715 ? 111.577 106.314 129.929 1.00 62.18  ? 707 PRO B N     1 
ATOM   9595  C  CA    . PRO B 1 715 ? 110.620 105.315 129.445 1.00 62.21  ? 707 PRO B CA    1 
ATOM   9596  C  C     . PRO B 1 715 ? 110.058 105.689 128.085 1.00 65.39  ? 707 PRO B C     1 
ATOM   9597  O  O     . PRO B 1 715 ? 109.946 106.865 127.730 1.00 67.53  ? 707 PRO B O     1 
ATOM   9598  C  CB    . PRO B 1 715 ? 109.528 105.324 130.518 1.00 68.35  ? 707 PRO B CB    1 
ATOM   9599  C  CG    . PRO B 1 715 ? 109.597 106.693 131.096 1.00 72.44  ? 707 PRO B CG    1 
ATOM   9600  C  CD    . PRO B 1 715 ? 111.048 107.083 131.068 1.00 62.85  ? 707 PRO B CD    1 
ATOM   9601  N  N     . HIS B 1 716 ? 109.708 104.662 127.316 1.00 62.02  ? 708 HIS B N     1 
ATOM   9602  C  CA    . HIS B 1 716 ? 109.165 104.849 125.981 1.00 63.57  ? 708 HIS B CA    1 
ATOM   9603  C  C     . HIS B 1 716 ? 108.132 103.779 125.671 1.00 65.69  ? 708 HIS B C     1 
ATOM   9604  O  O     . HIS B 1 716 ? 108.260 102.628 126.093 1.00 62.43  ? 708 HIS B O     1 
ATOM   9605  C  CB    . HIS B 1 716 ? 110.260 104.760 124.908 1.00 65.04  ? 708 HIS B CB    1 
ATOM   9606  C  CG    . HIS B 1 716 ? 110.861 103.396 124.768 1.00 60.66  ? 708 HIS B CG    1 
ATOM   9607  N  ND1   . HIS B 1 716 ? 110.192 102.343 124.185 1.00 62.23  ? 708 HIS B ND1   1 
ATOM   9608  C  CD2   . HIS B 1 716 ? 112.069 102.912 125.142 1.00 57.94  ? 708 HIS B CD2   1 
ATOM   9609  C  CE1   . HIS B 1 716 ? 110.961 101.270 124.203 1.00 63.54  ? 708 HIS B CE1   1 
ATOM   9610  N  NE2   . HIS B 1 716 ? 112.107 101.589 124.778 1.00 60.03  ? 708 HIS B NE2   1 
ATOM   9611  N  N     . ALA B 1 717 ? 107.105 104.175 124.929 1.00 73.14  ? 709 ALA B N     1 
ATOM   9612  C  CA    . ALA B 1 717 ? 106.111 103.217 124.476 1.00 77.88  ? 709 ALA B CA    1 
ATOM   9613  C  C     . ALA B 1 717 ? 106.749 102.117 123.633 1.00 77.35  ? 709 ALA B C     1 
ATOM   9614  O  O     . ALA B 1 717 ? 107.673 102.388 122.859 1.00 72.93  ? 709 ALA B O     1 
ATOM   9615  C  CB    . ALA B 1 717 ? 105.009 103.915 123.681 1.00 81.46  ? 709 ALA B CB    1 
ATOM   9616  N  N     . PRO B 1 718 ? 106.299 100.872 123.772 1.00 82.25  ? 710 PRO B N     1 
ATOM   9617  C  CA    . PRO B 1 718 ? 106.898 99.784  122.991 1.00 84.85  ? 710 PRO B CA    1 
ATOM   9618  C  C     . PRO B 1 718 ? 106.780 100.050 121.499 1.00 90.28  ? 710 PRO B C     1 
ATOM   9619  O  O     . PRO B 1 718 ? 105.724 100.447 121.001 1.00 92.59  ? 710 PRO B O     1 
ATOM   9620  C  CB    . PRO B 1 718 ? 106.087 98.554  123.416 1.00 85.03  ? 710 PRO B CB    1 
ATOM   9621  C  CG    . PRO B 1 718 ? 105.534 98.910  124.753 1.00 87.10  ? 710 PRO B CG    1 
ATOM   9622  C  CD    . PRO B 1 718 ? 105.263 100.383 124.697 1.00 83.56  ? 710 PRO B CD    1 
ATOM   9623  N  N     . SER B 1 719 ? 107.879 99.830  120.787 1.00 92.79  ? 711 SER B N     1 
ATOM   9624  C  CA    . SER B 1 719 ? 107.889 100.027 119.348 1.00 92.95  ? 711 SER B CA    1 
ATOM   9625  C  C     . SER B 1 719 ? 107.118 98.909  118.656 1.00 94.60  ? 711 SER B C     1 
ATOM   9626  O  O     . SER B 1 719 ? 106.814 97.868  119.247 1.00 96.86  ? 711 SER B O     1 
ATOM   9627  C  CB    . SER B 1 719 ? 109.323 100.079 118.827 1.00 84.60  ? 711 SER B CB    1 
ATOM   9628  O  OG    . SER B 1 719 ? 110.024 98.894  119.161 1.00 82.46  ? 711 SER B OG    1 
ATOM   9629  N  N     . PHE B 1 720 ? 106.793 99.139  117.382 1.00 90.51  ? 712 PHE B N     1 
ATOM   9630  C  CA    . PHE B 1 720 ? 106.110 98.107  116.611 1.00 90.87  ? 712 PHE B CA    1 
ATOM   9631  C  C     . PHE B 1 720 ? 106.954 96.846  116.510 1.00 90.69  ? 712 PHE B C     1 
ATOM   9632  O  O     . PHE B 1 720 ? 106.409 95.742  116.407 1.00 92.61  ? 712 PHE B O     1 
ATOM   9633  C  CB    . PHE B 1 720 ? 105.758 98.623  115.217 1.00 89.63  ? 712 PHE B CB    1 
ATOM   9634  C  CG    . PHE B 1 720 ? 105.111 97.591  114.339 1.00 88.10  ? 712 PHE B CG    1 
ATOM   9635  C  CD1   . PHE B 1 720 ? 103.777 97.262  114.503 1.00 86.42  ? 712 PHE B CD1   1 
ATOM   9636  C  CD2   . PHE B 1 720 ? 105.838 96.947  113.352 1.00 87.47  ? 712 PHE B CD2   1 
ATOM   9637  C  CE1   . PHE B 1 720 ? 103.180 96.311  113.700 1.00 84.16  ? 712 PHE B CE1   1 
ATOM   9638  C  CE2   . PHE B 1 720 ? 105.246 95.996  112.546 1.00 87.57  ? 712 PHE B CE2   1 
ATOM   9639  C  CZ    . PHE B 1 720 ? 103.916 95.678  112.721 1.00 87.25  ? 712 PHE B CZ    1 
ATOM   9640  N  N     . ASP B 1 721 ? 108.280 96.988  116.549 1.00 92.54  ? 713 ASP B N     1 
ATOM   9641  C  CA    . ASP B 1 721 ? 109.148 95.818  116.554 1.00 95.12  ? 713 ASP B CA    1 
ATOM   9642  C  C     . ASP B 1 721 ? 108.874 94.947  117.772 1.00 97.22  ? 713 ASP B C     1 
ATOM   9643  O  O     . ASP B 1 721 ? 108.609 93.748  117.645 1.00 99.85  ? 713 ASP B O     1 
ATOM   9644  C  CB    . ASP B 1 721 ? 110.612 96.254  116.522 1.00 93.12  ? 713 ASP B CB    1 
ATOM   9645  C  CG    . ASP B 1 721 ? 110.926 97.148  115.342 1.00 90.23  ? 713 ASP B CG    1 
ATOM   9646  O  OD1   . ASP B 1 721 ? 110.543 96.794  114.208 1.00 90.58  ? 713 ASP B OD1   1 
ATOM   9647  O  OD2   . ASP B 1 721 ? 111.548 98.210  115.549 1.00 88.23  ? 713 ASP B OD2   1 
ATOM   9648  N  N     . ILE B 1 722 ? 108.909 95.542  118.966 1.00 95.95  ? 714 ILE B N     1 
ATOM   9649  C  CA    . ILE B 1 722 ? 108.637 94.778  120.178 1.00 99.23  ? 714 ILE B CA    1 
ATOM   9650  C  C     . ILE B 1 722 ? 107.210 94.257  120.067 1.00 101.10 ? 714 ILE B C     1 
ATOM   9651  O  O     . ILE B 1 722 ? 106.973 93.043  120.109 1.00 101.40 ? 714 ILE B O     1 
ATOM   9652  C  CB    . ILE B 1 722 ? 108.936 95.628  121.425 1.00 101.11 ? 714 ILE B CB    1 
ATOM   9653  C  CG1   . ILE B 1 722 ? 110.330 96.249  121.326 1.00 101.61 ? 714 ILE B CG1   1 
ATOM   9654  C  CG2   . ILE B 1 722 ? 108.818 94.783  122.683 1.00 100.22 ? 714 ILE B CG2   1 
ATOM   9655  C  CD1   . ILE B 1 722 ? 110.692 97.123  122.507 1.00 97.67  ? 714 ILE B CD1   1 
ATOM   9656  N  N     . THR B 1 723 ? 106.245 95.163  119.891 1.00 99.77  ? 715 THR B N     1 
ATOM   9657  C  CA    . THR B 1 723 ? 104.839 94.769  119.859 1.00 99.08  ? 715 THR B CA    1 
ATOM   9658  C  C     . THR B 1 723 ? 104.547 93.558  118.981 1.00 100.61 ? 715 THR B C     1 
ATOM   9659  O  O     . THR B 1 723 ? 103.895 92.603  119.417 1.00 103.01 ? 715 THR B O     1 
ATOM   9660  C  CB    . THR B 1 723 ? 103.980 95.957  119.430 1.00 96.27  ? 715 THR B CB    1 
ATOM   9661  O  OG1   . THR B 1 723 ? 104.177 97.046  120.339 1.00 96.26  ? 715 THR B OG1   1 
ATOM   9662  C  CG2   . THR B 1 723 ? 102.511 95.570  119.412 1.00 95.20  ? 715 THR B CG2   1 
ATOM   9663  N  N     . LYS B 1 724 ? 105.028 93.576  117.738 1.00 100.21 ? 716 LYS B N     1 
ATOM   9664  C  CA    . LYS B 1 724 ? 104.784 92.453  116.841 1.00 100.68 ? 716 LYS B CA    1 
ATOM   9665  C  C     . LYS B 1 724 ? 105.676 91.271  117.192 1.00 102.62 ? 716 LYS B C     1 
ATOM   9666  O  O     . LYS B 1 724 ? 105.192 90.206  117.591 1.00 104.37 ? 716 LYS B O     1 
ATOM   9667  C  CB    . LYS B 1 724 ? 105.005 92.887  115.390 1.00 97.70  ? 716 LYS B CB    1 
ATOM   9668  C  CG    . LYS B 1 724 ? 105.003 91.747  114.386 1.00 98.19  ? 716 LYS B CG    1 
ATOM   9669  C  CD    . LYS B 1 724 ? 103.676 91.011  114.364 1.00 99.69  ? 716 LYS B CD    1 
ATOM   9670  C  CE    . LYS B 1 724 ? 103.690 89.894  113.334 1.00 99.91  ? 716 LYS B CE    1 
ATOM   9671  N  NZ    . LYS B 1 724 ? 104.012 90.403  111.973 1.00 97.48  ? 716 LYS B NZ    1 
ATOM   9672  N  N     . PHE B 1 725 ? 106.989 91.442  117.053 1.00 105.41 ? 717 PHE B N     1 
ATOM   9673  C  CA    . PHE B 1 725 ? 107.942 90.375  117.324 1.00 109.69 ? 717 PHE B CA    1 
ATOM   9674  C  C     . PHE B 1 725 ? 108.511 90.554  118.731 1.00 110.45 ? 717 PHE B C     1 
ATOM   9675  O  O     . PHE B 1 725 ? 109.693 90.836  118.935 1.00 112.15 ? 717 PHE B O     1 
ATOM   9676  C  CB    . PHE B 1 725 ? 109.037 90.377  116.263 1.00 106.88 ? 717 PHE B CB    1 
ATOM   9677  C  CG    . PHE B 1 725 ? 108.529 90.172  114.865 1.00 105.85 ? 717 PHE B CG    1 
ATOM   9678  C  CD1   . PHE B 1 725 ? 108.127 88.918  114.433 1.00 106.46 ? 717 PHE B CD1   1 
ATOM   9679  C  CD2   . PHE B 1 725 ? 108.462 91.232  113.978 1.00 108.50 ? 717 PHE B CD2   1 
ATOM   9680  C  CE1   . PHE B 1 725 ? 107.661 88.729  113.146 1.00 106.67 ? 717 PHE B CE1   1 
ATOM   9681  C  CE2   . PHE B 1 725 ? 107.996 91.050  112.690 1.00 109.04 ? 717 PHE B CE2   1 
ATOM   9682  C  CZ    . PHE B 1 725 ? 107.597 89.796  112.274 1.00 107.01 ? 717 PHE B CZ    1 
ATOM   9683  N  N     . ARG B 1 726 ? 107.630 90.386  119.715 1.00 106.93 ? 718 ARG B N     1 
ATOM   9684  C  CA    . ARG B 1 726 ? 107.998 90.576  121.112 1.00 109.84 ? 718 ARG B CA    1 
ATOM   9685  C  C     . ARG B 1 726 ? 108.734 89.368  121.679 1.00 118.06 ? 718 ARG B C     1 
ATOM   9686  O  O     . ARG B 1 726 ? 108.406 88.892  122.771 1.00 123.53 ? 718 ARG B O     1 
ATOM   9687  C  CB    . ARG B 1 726 ? 106.740 90.864  121.936 1.00 107.23 ? 718 ARG B CB    1 
ATOM   9688  C  CG    . ARG B 1 726 ? 105.639 89.833  121.735 1.00 108.94 ? 718 ARG B CG    1 
ATOM   9689  C  CD    . ARG B 1 726 ? 104.330 90.261  122.366 1.00 112.52 ? 718 ARG B CD    1 
ATOM   9690  N  NE    . ARG B 1 726 ? 103.336 89.195  122.302 1.00 116.86 ? 718 ARG B NE    1 
ATOM   9691  C  CZ    . ARG B 1 726 ? 102.603 88.914  121.233 1.00 116.07 ? 718 ARG B CZ    1 
ATOM   9692  N  NH1   . ARG B 1 726 ? 102.722 89.606  120.111 1.00 111.18 ? 718 ARG B NH1   1 
ATOM   9693  N  NH2   . ARG B 1 726 ? 101.731 87.912  121.290 1.00 118.77 ? 718 ARG B NH2   1 
ATOM   9694  N  N     . SER B 1 727 ? 109.753 88.895  120.959 1.00 112.78 ? 719 SER B N     1 
ATOM   9695  C  CA    . SER B 1 727 ? 110.549 87.740  121.376 1.00 116.95 ? 719 SER B CA    1 
ATOM   9696  C  C     . SER B 1 727 ? 109.655 86.560  121.746 1.00 120.83 ? 719 SER B C     1 
ATOM   9697  O  O     . SER B 1 727 ? 109.867 85.883  122.754 1.00 122.44 ? 719 SER B O     1 
ATOM   9698  C  CB    . SER B 1 727 ? 111.487 88.102  122.530 1.00 121.33 ? 719 SER B CB    1 
ATOM   9699  O  OG    . SER B 1 727 ? 110.763 88.438  123.699 1.00 123.53 ? 719 SER B OG    1 
ATOM   9700  N  N     . ASN B 1 728 ? 108.635 86.318  120.926 1.00 121.36 ? 720 ASN B N     1 
ATOM   9701  C  CA    . ASN B 1 728 ? 107.686 85.244  121.171 1.00 124.65 ? 720 ASN B CA    1 
ATOM   9702  C  C     . ASN B 1 728 ? 107.361 84.541  119.861 1.00 127.45 ? 720 ASN B C     1 
ATOM   9703  O  O     . ASN B 1 728 ? 107.309 85.166  118.799 1.00 125.50 ? 720 ASN B O     1 
ATOM   9704  C  CB    . ASN B 1 728 ? 106.397 85.768  121.821 1.00 119.98 ? 720 ASN B CB    1 
ATOM   9705  C  CG    . ASN B 1 728 ? 105.422 84.658  122.158 1.00 122.06 ? 720 ASN B CG    1 
ATOM   9706  O  OD1   . ASN B 1 728 ? 105.815 83.507  122.344 1.00 125.06 ? 720 ASN B OD1   1 
ATOM   9707  N  ND2   . ASN B 1 728 ? 104.141 84.998  122.233 1.00 121.41 ? 720 ASN B ND2   1 
ATOM   9708  N  N     . LYS B 1 729 ? 107.148 83.229  119.954 1.00 127.95 ? 721 LYS B N     1 
ATOM   9709  C  CA    . LYS B 1 729 ? 106.694 82.390  118.835 1.00 123.82 ? 721 LYS B CA    1 
ATOM   9710  C  C     . LYS B 1 729 ? 107.758 82.427  117.740 1.00 126.21 ? 721 LYS B C     1 
ATOM   9711  O  O     . LYS B 1 729 ? 108.928 82.114  118.022 1.00 123.07 ? 721 LYS B O     1 
ATOM   9712  C  CB    . LYS B 1 729 ? 105.300 82.837  118.410 1.00 118.55 ? 721 LYS B CB    1 
ATOM   9713  C  CG    . LYS B 1 729 ? 104.248 82.725  119.497 1.00 121.71 ? 721 LYS B CG    1 
ATOM   9714  C  CD    . LYS B 1 729 ? 102.907 83.257  119.019 1.00 124.93 ? 721 LYS B CD    1 
ATOM   9715  C  CE    . LYS B 1 729 ? 101.866 83.204  120.124 1.00 131.03 ? 721 LYS B CE    1 
ATOM   9716  N  NZ    . LYS B 1 729 ? 100.556 83.758  119.680 1.00 130.92 ? 721 LYS B NZ    1 
ATOM   9717  N  N     . GLN B 1 730 ? 107.408 82.786  116.501 1.00 129.32 ? 722 GLN B N     1 
ATOM   9718  C  CA    . GLN B 1 730 ? 108.344 82.679  115.387 1.00 127.79 ? 722 GLN B CA    1 
ATOM   9719  C  C     . GLN B 1 730 ? 109.570 83.554  115.600 1.00 126.94 ? 722 GLN B C     1 
ATOM   9720  O  O     . GLN B 1 730 ? 110.697 83.132  115.317 1.00 122.73 ? 722 GLN B O     1 
ATOM   9721  C  CB    . GLN B 1 730 ? 107.642 83.048  114.080 1.00 124.48 ? 722 GLN B CB    1 
ATOM   9722  C  CG    . GLN B 1 730 ? 108.554 83.053  112.864 1.00 126.40 ? 722 GLN B CG    1 
ATOM   9723  C  CD    . GLN B 1 730 ? 107.858 83.563  111.617 1.00 129.39 ? 722 GLN B CD    1 
ATOM   9724  O  OE1   . GLN B 1 730 ? 106.645 83.773  111.610 1.00 134.00 ? 722 GLN B OE1   1 
ATOM   9725  N  NE2   . GLN B 1 730 ? 108.626 83.769  110.554 1.00 123.12 ? 722 GLN B NE2   1 
ATOM   9726  N  N     . TYR B 1 731 ? 109.374 84.780  116.091 1.00 124.64 ? 723 TYR B N     1 
ATOM   9727  C  CA    . TYR B 1 731 ? 110.516 85.658  116.315 1.00 117.89 ? 723 TYR B CA    1 
ATOM   9728  C  C     . TYR B 1 731 ? 111.430 85.113  117.401 1.00 117.03 ? 723 TYR B C     1 
ATOM   9729  O  O     . TYR B 1 731 ? 112.655 85.218  117.294 1.00 113.31 ? 723 TYR B O     1 
ATOM   9730  C  CB    . TYR B 1 731 ? 110.058 87.064  116.678 1.00 110.70 ? 723 TYR B CB    1 
ATOM   9731  C  CG    . TYR B 1 731 ? 111.214 88.004  116.941 1.00 110.24 ? 723 TYR B CG    1 
ATOM   9732  C  CD1   . TYR B 1 731 ? 111.937 88.555  115.894 1.00 106.60 ? 723 TYR B CD1   1 
ATOM   9733  C  CD2   . TYR B 1 731 ? 111.580 88.342  118.235 1.00 113.50 ? 723 TYR B CD2   1 
ATOM   9734  C  CE1   . TYR B 1 731 ? 112.992 89.416  116.127 1.00 104.56 ? 723 TYR B CE1   1 
ATOM   9735  C  CE2   . TYR B 1 731 ? 112.633 89.202  118.480 1.00 111.50 ? 723 TYR B CE2   1 
ATOM   9736  C  CZ    . TYR B 1 731 ? 113.337 89.736  117.422 1.00 106.46 ? 723 TYR B CZ    1 
ATOM   9737  O  OH    . TYR B 1 731 ? 114.387 90.593  117.659 1.00 99.76  ? 723 TYR B OH    1 
ATOM   9738  N  N     . ARG B 1 732 ? 110.859 84.548  118.468 1.00 117.85 ? 724 ARG B N     1 
ATOM   9739  C  CA    . ARG B 1 732 ? 111.696 83.961  119.509 1.00 117.45 ? 724 ARG B CA    1 
ATOM   9740  C  C     . ARG B 1 732 ? 112.505 82.793  118.963 1.00 116.40 ? 724 ARG B C     1 
ATOM   9741  O  O     . ARG B 1 732 ? 113.701 82.666  119.255 1.00 116.35 ? 724 ARG B O     1 
ATOM   9742  C  CB    . ARG B 1 732 ? 110.840 83.516  120.694 1.00 123.26 ? 724 ARG B CB    1 
ATOM   9743  C  CG    . ARG B 1 732 ? 111.643 82.953  121.860 1.00 122.71 ? 724 ARG B CG    1 
ATOM   9744  C  CD    . ARG B 1 732 ? 110.808 82.871  123.129 1.00 120.66 ? 724 ARG B CD    1 
ATOM   9745  N  NE    . ARG B 1 732 ? 109.627 82.032  122.962 1.00 125.00 ? 724 ARG B NE    1 
ATOM   9746  C  CZ    . ARG B 1 732 ? 109.569 80.749  123.290 1.00 129.33 ? 724 ARG B CZ    1 
ATOM   9747  N  NH1   . ARG B 1 732 ? 110.610 80.122  123.812 1.00 129.40 ? 724 ARG B NH1   1 
ATOM   9748  N  NH2   . ARG B 1 732 ? 108.437 80.080  123.092 1.00 130.69 ? 724 ARG B NH2   1 
ATOM   9749  N  N     . ILE B 1 733 ? 111.874 81.940  118.152 1.00 116.03 ? 725 ILE B N     1 
ATOM   9750  C  CA    . ILE B 1 733 ? 112.593 80.813  117.564 1.00 117.04 ? 725 ILE B CA    1 
ATOM   9751  C  C     . ILE B 1 733 ? 113.716 81.308  116.661 1.00 115.43 ? 725 ILE B C     1 
ATOM   9752  O  O     . ILE B 1 733 ? 114.845 80.801  116.709 1.00 110.66 ? 725 ILE B O     1 
ATOM   9753  C  CB    . ILE B 1 733 ? 111.618 79.895  116.803 1.00 116.77 ? 725 ILE B CB    1 
ATOM   9754  C  CG1   . ILE B 1 733 ? 110.521 79.389  117.740 1.00 112.93 ? 725 ILE B CG1   1 
ATOM   9755  C  CG2   . ILE B 1 733 ? 112.364 78.726  116.180 1.00 114.43 ? 725 ILE B CG2   1 
ATOM   9756  C  CD1   . ILE B 1 733 ? 109.466 78.555  117.049 1.00 107.56 ? 725 ILE B CD1   1 
ATOM   9757  N  N     . CYS B 1 734 ? 113.428 82.312  115.830 1.00 112.65 ? 726 CYS B N     1 
ATOM   9758  C  CA    . CYS B 1 734 ? 114.435 82.823  114.906 1.00 111.89 ? 726 CYS B CA    1 
ATOM   9759  C  C     . CYS B 1 734 ? 115.575 83.512  115.646 1.00 109.70 ? 726 CYS B C     1 
ATOM   9760  O  O     . CYS B 1 734 ? 116.741 83.383  115.256 1.00 107.32 ? 726 CYS B O     1 
ATOM   9761  C  CB    . CYS B 1 734 ? 113.787 83.774  113.902 1.00 110.94 ? 726 CYS B CB    1 
ATOM   9762  S  SG    . CYS B 1 734 ? 112.586 82.977  112.810 1.00 119.52 ? 726 CYS B SG    1 
ATOM   9763  N  N     . LEU B 1 735 ? 115.263 84.252  116.711 1.00 109.57 ? 727 LEU B N     1 
ATOM   9764  C  CA    . LEU B 1 735 ? 116.306 84.901  117.496 1.00 104.25 ? 727 LEU B CA    1 
ATOM   9765  C  C     . LEU B 1 735 ? 117.175 83.875  118.210 1.00 102.23 ? 727 LEU B C     1 
ATOM   9766  O  O     . LEU B 1 735 ? 118.395 84.047  118.304 1.00 99.05  ? 727 LEU B O     1 
ATOM   9767  C  CB    . LEU B 1 735 ? 115.682 85.871  118.497 1.00 101.58 ? 727 LEU B CB    1 
ATOM   9768  C  CG    . LEU B 1 735 ? 116.669 86.680  119.337 1.00 96.91  ? 727 LEU B CG    1 
ATOM   9769  C  CD1   . LEU B 1 735 ? 117.632 87.433  118.437 1.00 88.67  ? 727 LEU B CD1   1 
ATOM   9770  C  CD2   . LEU B 1 735 ? 115.929 87.637  120.257 1.00 91.14  ? 727 LEU B CD2   1 
ATOM   9771  N  N     . LYS B 1 736 ? 116.567 82.800  118.717 1.00 102.65 ? 728 LYS B N     1 
ATOM   9772  C  CA    . LYS B 1 736 ? 117.356 81.725  119.307 1.00 104.15 ? 728 LYS B CA    1 
ATOM   9773  C  C     . LYS B 1 736 ? 118.263 81.081  118.267 1.00 106.43 ? 728 LYS B C     1 
ATOM   9774  O  O     . LYS B 1 736 ? 119.426 80.770  118.552 1.00 105.53 ? 728 LYS B O     1 
ATOM   9775  C  CB    . LYS B 1 736 ? 116.432 80.685  119.939 1.00 107.74 ? 728 LYS B CB    1 
ATOM   9776  C  CG    . LYS B 1 736 ? 117.158 79.557  120.651 1.00 109.63 ? 728 LYS B CG    1 
ATOM   9777  C  CD    . LYS B 1 736 ? 116.174 78.594  121.293 1.00 111.46 ? 728 LYS B CD    1 
ATOM   9778  C  CE    . LYS B 1 736 ? 116.894 77.481  122.035 1.00 114.87 ? 728 LYS B CE    1 
ATOM   9779  N  NZ    . LYS B 1 736 ? 115.938 76.542  122.684 1.00 118.56 ? 728 LYS B NZ    1 
ATOM   9780  N  N     . THR B 1 737 ? 117.749 80.875  117.051 1.00 104.84 ? 729 THR B N     1 
ATOM   9781  C  CA    . THR B 1 737 ? 118.572 80.308  115.986 1.00 104.13 ? 729 THR B CA    1 
ATOM   9782  C  C     . THR B 1 737 ? 119.737 81.229  115.636 1.00 101.16 ? 729 THR B C     1 
ATOM   9783  O  O     . THR B 1 737 ? 120.866 80.765  115.430 1.00 101.79 ? 729 THR B O     1 
ATOM   9784  C  CB    . THR B 1 737 ? 117.714 80.037  114.750 1.00 103.87 ? 729 THR B CB    1 
ATOM   9785  O  OG1   . THR B 1 737 ? 116.535 79.320  115.135 1.00 102.23 ? 729 THR B OG1   1 
ATOM   9786  C  CG2   . THR B 1 737 ? 118.490 79.212  113.736 1.00 104.97 ? 729 THR B CG2   1 
ATOM   9787  N  N     . LEU B 1 738 ? 119.481 82.537  115.562 1.00 95.07  ? 730 LEU B N     1 
ATOM   9788  C  CA    . LEU B 1 738 ? 120.549 83.492  115.281 1.00 93.92  ? 730 LEU B CA    1 
ATOM   9789  C  C     . LEU B 1 738 ? 121.585 83.506  116.399 1.00 95.86  ? 730 LEU B C     1 
ATOM   9790  O  O     . LEU B 1 738 ? 122.789 83.608  116.140 1.00 94.79  ? 730 LEU B O     1 
ATOM   9791  C  CB    . LEU B 1 738 ? 119.964 84.888  115.073 1.00 84.86  ? 730 LEU B CB    1 
ATOM   9792  C  CG    . LEU B 1 738 ? 119.077 85.089  113.844 1.00 82.60  ? 730 LEU B CG    1 
ATOM   9793  C  CD1   . LEU B 1 738 ? 118.427 86.462  113.870 1.00 77.69  ? 730 LEU B CD1   1 
ATOM   9794  C  CD2   . LEU B 1 738 ? 119.880 84.901  112.569 1.00 85.01  ? 730 LEU B CD2   1 
ATOM   9795  N  N     . LYS B 1 739 ? 121.132 83.413  117.652 1.00 94.44  ? 731 LYS B N     1 
ATOM   9796  C  CA    . LYS B 1 739 ? 122.057 83.329  118.777 1.00 91.63  ? 731 LYS B CA    1 
ATOM   9797  C  C     . LYS B 1 739 ? 122.925 82.081  118.683 1.00 92.70  ? 731 LYS B C     1 
ATOM   9798  O  O     . LYS B 1 739 ? 124.137 82.137  118.925 1.00 94.40  ? 731 LYS B O     1 
ATOM   9799  C  CB    . LYS B 1 739 ? 121.273 83.345  120.089 1.00 90.07  ? 731 LYS B CB    1 
ATOM   9800  C  CG    . LYS B 1 739 ? 122.040 82.836  121.296 1.00 91.35  ? 731 LYS B CG    1 
ATOM   9801  C  CD    . LYS B 1 739 ? 121.126 82.724  122.506 1.00 94.34  ? 731 LYS B CD    1 
ATOM   9802  C  CE    . LYS B 1 739 ? 121.821 82.041  123.672 1.00 100.97 ? 731 LYS B CE    1 
ATOM   9803  N  NZ    . LYS B 1 739 ? 120.943 81.954  124.871 1.00 104.40 ? 731 LYS B NZ    1 
ATOM   9804  N  N     . GLU B 1 740 ? 122.321 80.945  118.328 1.00 93.06  ? 732 GLU B N     1 
ATOM   9805  C  CA    . GLU B 1 740 ? 123.090 79.716  118.168 1.00 96.66  ? 732 GLU B CA    1 
ATOM   9806  C  C     . GLU B 1 740 ? 124.119 79.850  117.051 1.00 97.96  ? 732 GLU B C     1 
ATOM   9807  O  O     . GLU B 1 740 ? 125.266 79.409  117.196 1.00 98.86  ? 732 GLU B O     1 
ATOM   9808  C  CB    . GLU B 1 740 ? 122.150 78.543  117.892 1.00 101.45 ? 732 GLU B CB    1 
ATOM   9809  C  CG    . GLU B 1 740 ? 121.217 78.213  119.044 1.00 106.74 ? 732 GLU B CG    1 
ATOM   9810  C  CD    . GLU B 1 740 ? 120.130 77.234  118.648 1.00 109.84 ? 732 GLU B CD    1 
ATOM   9811  O  OE1   . GLU B 1 740 ? 120.094 76.828  117.468 1.00 108.83 ? 732 GLU B OE1   1 
ATOM   9812  O  OE2   . GLU B 1 740 ? 119.309 76.873  119.518 1.00 107.65 ? 732 GLU B OE2   1 
ATOM   9813  N  N     . GLU B 1 741 ? 123.724 80.452  115.927 1.00 98.47  ? 733 GLU B N     1 
ATOM   9814  C  CA    . GLU B 1 741 ? 124.662 80.645  114.825 1.00 98.66  ? 733 GLU B CA    1 
ATOM   9815  C  C     . GLU B 1 741 ? 125.810 81.560  115.230 1.00 96.07  ? 733 GLU B C     1 
ATOM   9816  O  O     . GLU B 1 741 ? 126.970 81.312  114.875 1.00 98.37  ? 733 GLU B O     1 
ATOM   9817  C  CB    . GLU B 1 741 ? 123.933 81.205  113.604 1.00 97.70  ? 733 GLU B CB    1 
ATOM   9818  C  CG    . GLU B 1 741 ? 122.923 80.249  112.990 1.00 99.22  ? 733 GLU B CG    1 
ATOM   9819  C  CD    . GLU B 1 741 ? 122.268 80.815  111.745 1.00 107.20 ? 733 GLU B CD    1 
ATOM   9820  O  OE1   . GLU B 1 741 ? 122.630 81.940  111.340 1.00 103.97 ? 733 GLU B OE1   1 
ATOM   9821  O  OE2   . GLU B 1 741 ? 121.392 80.135  111.172 1.00 111.32 ? 733 GLU B OE2   1 
ATOM   9822  N  N     . PHE B 1 742 ? 125.508 82.629  115.970 1.00 90.97  ? 734 PHE B N     1 
ATOM   9823  C  CA    . PHE B 1 742 ? 126.563 83.520  116.439 1.00 88.07  ? 734 PHE B CA    1 
ATOM   9824  C  C     . PHE B 1 742 ? 127.510 82.800  117.388 1.00 90.59  ? 734 PHE B C     1 
ATOM   9825  O  O     . PHE B 1 742 ? 128.726 83.007  117.335 1.00 90.20  ? 734 PHE B O     1 
ATOM   9826  C  CB    . PHE B 1 742 ? 125.963 84.751  117.117 1.00 80.71  ? 734 PHE B CB    1 
ATOM   9827  C  CG    . PHE B 1 742 ? 126.992 85.668  117.708 1.00 81.26  ? 734 PHE B CG    1 
ATOM   9828  C  CD1   . PHE B 1 742 ? 127.705 86.537  116.902 1.00 80.66  ? 734 PHE B CD1   1 
ATOM   9829  C  CD2   . PHE B 1 742 ? 127.254 85.654  119.067 1.00 80.72  ? 734 PHE B CD2   1 
ATOM   9830  C  CE1   . PHE B 1 742 ? 128.658 87.378  117.441 1.00 80.44  ? 734 PHE B CE1   1 
ATOM   9831  C  CE2   . PHE B 1 742 ? 128.204 86.492  119.611 1.00 77.19  ? 734 PHE B CE2   1 
ATOM   9832  C  CZ    . PHE B 1 742 ? 128.908 87.354  118.797 1.00 77.76  ? 734 PHE B CZ    1 
ATOM   9833  N  N     . GLN B 1 743 ? 126.970 81.958  118.272 1.00 94.44  ? 735 GLN B N     1 
ATOM   9834  C  CA    . GLN B 1 743 ? 127.825 81.188  119.171 1.00 93.71  ? 735 GLN B CA    1 
ATOM   9835  C  C     . GLN B 1 743 ? 128.721 80.231  118.394 1.00 94.87  ? 735 GLN B C     1 
ATOM   9836  O  O     . GLN B 1 743 ? 129.903 80.069  118.722 1.00 97.02  ? 735 GLN B O     1 
ATOM   9837  C  CB    . GLN B 1 743 ? 126.973 80.423  120.183 1.00 94.83  ? 735 GLN B CB    1 
ATOM   9838  C  CG    . GLN B 1 743 ? 126.287 81.305  121.212 1.00 99.02  ? 735 GLN B CG    1 
ATOM   9839  C  CD    . GLN B 1 743 ? 125.446 80.509  122.188 1.00 106.02 ? 735 GLN B CD    1 
ATOM   9840  O  OE1   . GLN B 1 743 ? 125.216 79.315  121.997 1.00 107.43 ? 735 GLN B OE1   1 
ATOM   9841  N  NE2   . GLN B 1 743 ? 124.984 81.167  123.244 1.00 107.14 ? 735 GLN B NE2   1 
ATOM   9842  N  N     . GLN B 1 744 ? 128.172 79.582  117.365 1.00 92.70  ? 736 GLN B N     1 
ATOM   9843  C  CA    . GLN B 1 744 ? 128.981 78.685  116.545 1.00 92.30  ? 736 GLN B CA    1 
ATOM   9844  C  C     . GLN B 1 744 ? 130.094 79.442  115.831 1.00 95.25  ? 736 GLN B C     1 
ATOM   9845  O  O     . GLN B 1 744 ? 131.234 78.967  115.760 1.00 100.05 ? 736 GLN B O     1 
ATOM   9846  C  CB    . GLN B 1 744 ? 128.095 77.952  115.538 1.00 94.59  ? 736 GLN B CB    1 
ATOM   9847  C  CG    . GLN B 1 744 ? 127.082 77.016  116.174 1.00 94.31  ? 736 GLN B CG    1 
ATOM   9848  C  CD    . GLN B 1 744 ? 126.173 76.360  115.155 1.00 101.41 ? 736 GLN B CD    1 
ATOM   9849  O  OE1   . GLN B 1 744 ? 126.440 76.397  113.954 1.00 106.16 ? 736 GLN B OE1   1 
ATOM   9850  N  NE2   . GLN B 1 744 ? 125.090 75.758  115.630 1.00 97.94  ? 736 GLN B NE2   1 
ATOM   9851  N  N     . ASP B 1 745 ? 129.782 80.624  115.293 1.00 92.40  ? 737 ASP B N     1 
ATOM   9852  C  CA    . ASP B 1 745 ? 130.812 81.428  114.641 1.00 93.88  ? 737 ASP B CA    1 
ATOM   9853  C  C     . ASP B 1 745 ? 131.867 81.893  115.638 1.00 94.31  ? 737 ASP B C     1 
ATOM   9854  O  O     . ASP B 1 745 ? 133.058 81.951  115.308 1.00 94.05  ? 737 ASP B O     1 
ATOM   9855  C  CB    . ASP B 1 745 ? 130.176 82.621  113.929 1.00 96.79  ? 737 ASP B CB    1 
ATOM   9856  C  CG    . ASP B 1 745 ? 129.335 82.206  112.739 1.00 98.57  ? 737 ASP B CG    1 
ATOM   9857  O  OD1   . ASP B 1 745 ? 129.578 81.110  112.192 1.00 98.90  ? 737 ASP B OD1   1 
ATOM   9858  O  OD2   . ASP B 1 745 ? 128.434 82.976  112.347 1.00 96.59  ? 737 ASP B OD2   1 
ATOM   9859  N  N     . MET B 1 746 ? 131.449 82.233  116.860 1.00 95.12  ? 738 MET B N     1 
ATOM   9860  C  CA    . MET B 1 746 ? 132.403 82.586  117.906 1.00 92.32  ? 738 MET B CA    1 
ATOM   9861  C  C     . MET B 1 746 ? 133.336 81.423  118.209 1.00 92.88  ? 738 MET B C     1 
ATOM   9862  O  O     . MET B 1 746 ? 134.550 81.609  118.349 1.00 94.73  ? 738 MET B O     1 
ATOM   9863  C  CB    . MET B 1 746 ? 131.658 83.009  119.172 1.00 90.36  ? 738 MET B CB    1 
ATOM   9864  C  CG    . MET B 1 746 ? 131.041 84.390  119.107 1.00 93.02  ? 738 MET B CG    1 
ATOM   9865  S  SD    . MET B 1 746 ? 132.274 85.688  119.299 1.00 102.93 ? 738 MET B SD    1 
ATOM   9866  C  CE    . MET B 1 746 ? 132.940 85.270  120.907 1.00 81.64  ? 738 MET B CE    1 
ATOM   9867  N  N     . SER B 1 747 ? 132.780 80.216  118.320 1.00 95.12  ? 739 SER B N     1 
ATOM   9868  C  CA    . SER B 1 747 ? 133.603 79.042  118.589 1.00 96.70  ? 739 SER B CA    1 
ATOM   9869  C  C     . SER B 1 747 ? 134.581 78.781  117.451 1.00 95.60  ? 739 SER B C     1 
ATOM   9870  O  O     . SER B 1 747 ? 135.750 78.456  117.688 1.00 96.66  ? 739 SER B O     1 
ATOM   9871  C  CB    . SER B 1 747 ? 132.713 77.821  118.821 1.00 95.62  ? 739 SER B CB    1 
ATOM   9872  O  OG    . SER B 1 747 ? 131.823 78.036  119.902 1.00 94.79  ? 739 SER B OG    1 
ATOM   9873  N  N     . ARG B 1 748 ? 134.121 78.918  116.206 1.00 92.72  ? 740 ARG B N     1 
ATOM   9874  C  CA    . ARG B 1 748 ? 134.979 78.607  115.067 1.00 93.10  ? 740 ARG B CA    1 
ATOM   9875  C  C     . ARG B 1 748 ? 136.081 79.646  114.885 1.00 93.49  ? 740 ARG B C     1 
ATOM   9876  O  O     . ARG B 1 748 ? 137.217 79.297  114.545 1.00 95.66  ? 740 ARG B O     1 
ATOM   9877  C  CB    . ARG B 1 748 ? 134.142 78.491  113.794 1.00 96.85  ? 740 ARG B CB    1 
ATOM   9878  C  CG    . ARG B 1 748 ? 133.186 77.311  113.783 1.00 103.76 ? 740 ARG B CG    1 
ATOM   9879  C  CD    . ARG B 1 748 ? 132.498 77.175  112.436 1.00 115.40 ? 740 ARG B CD    1 
ATOM   9880  N  NE    . ARG B 1 748 ? 131.603 76.025  112.394 1.00 130.13 ? 740 ARG B NE    1 
ATOM   9881  C  CZ    . ARG B 1 748 ? 130.956 75.618  111.310 1.00 137.30 ? 740 ARG B CZ    1 
ATOM   9882  N  NH1   . ARG B 1 748 ? 131.085 76.245  110.152 1.00 136.35 ? 740 ARG B NH1   1 
ATOM   9883  N  NH2   . ARG B 1 748 ? 130.161 74.555  111.390 1.00 143.28 ? 740 ARG B NH2   1 
ATOM   9884  N  N     . ARG B 1 749 ? 135.769 80.925  115.102 1.00 95.38  ? 741 ARG B N     1 
ATOM   9885  C  CA    . ARG B 1 749 ? 136.709 81.981  114.738 1.00 95.68  ? 741 ARG B CA    1 
ATOM   9886  C  C     . ARG B 1 749 ? 137.884 82.060  115.708 1.00 93.22  ? 741 ARG B C     1 
ATOM   9887  O  O     . ARG B 1 749 ? 139.029 82.257  115.286 1.00 90.15  ? 741 ARG B O     1 
ATOM   9888  C  CB    . ARG B 1 749 ? 135.983 83.324  114.663 1.00 94.46  ? 741 ARG B CB    1 
ATOM   9889  C  CG    . ARG B 1 749 ? 136.857 84.478  114.199 1.00 89.20  ? 741 ARG B CG    1 
ATOM   9890  C  CD    . ARG B 1 749 ? 136.052 85.757  114.055 1.00 90.45  ? 741 ARG B CD    1 
ATOM   9891  N  NE    . ARG B 1 749 ? 136.888 86.884  113.660 1.00 95.37  ? 741 ARG B NE    1 
ATOM   9892  C  CZ    . ARG B 1 749 ? 136.437 88.113  113.448 1.00 95.91  ? 741 ARG B CZ    1 
ATOM   9893  N  NH1   . ARG B 1 749 ? 135.156 88.412  113.581 1.00 94.14  ? 741 ARG B NH1   1 
ATOM   9894  N  NH2   . ARG B 1 749 ? 137.295 89.066  113.094 1.00 93.61  ? 741 ARG B NH2   1 
ATOM   9895  N  N     . TYR B 1 750 ? 137.626 81.917  117.009 1.00 93.50  ? 742 TYR B N     1 
ATOM   9896  C  CA    . TYR B 1 750 ? 138.661 82.101  118.017 1.00 91.19  ? 742 TYR B CA    1 
ATOM   9897  C  C     . TYR B 1 750 ? 139.070 80.816  118.721 1.00 95.51  ? 742 TYR B C     1 
ATOM   9898  O  O     . TYR B 1 750 ? 140.162 80.770  119.298 1.00 99.17  ? 742 TYR B O     1 
ATOM   9899  C  CB    . TYR B 1 750 ? 138.203 83.125  119.066 1.00 89.54  ? 742 TYR B CB    1 
ATOM   9900  C  CG    . TYR B 1 750 ? 137.747 84.436  118.472 1.00 84.22  ? 742 TYR B CG    1 
ATOM   9901  C  CD1   . TYR B 1 750 ? 138.655 85.444  118.184 1.00 82.34  ? 742 TYR B CD1   1 
ATOM   9902  C  CD2   . TYR B 1 750 ? 136.407 84.663  118.196 1.00 83.59  ? 742 TYR B CD2   1 
ATOM   9903  C  CE1   . TYR B 1 750 ? 138.241 86.642  117.639 1.00 82.95  ? 742 TYR B CE1   1 
ATOM   9904  C  CE2   . TYR B 1 750 ? 135.984 85.857  117.652 1.00 85.80  ? 742 TYR B CE2   1 
ATOM   9905  C  CZ    . TYR B 1 750 ? 136.904 86.843  117.375 1.00 85.31  ? 742 TYR B CZ    1 
ATOM   9906  O  OH    . TYR B 1 750 ? 136.483 88.034  116.832 1.00 86.36  ? 742 TYR B OH    1 
ATOM   9907  N  N     . GLY B 1 751 ? 138.235 79.781  118.698 1.00 97.54  ? 743 GLY B N     1 
ATOM   9908  C  CA    . GLY B 1 751 ? 138.602 78.503  119.274 1.00 100.30 ? 743 GLY B CA    1 
ATOM   9909  C  C     . GLY B 1 751 ? 138.616 78.463  120.788 1.00 102.24 ? 743 GLY B C     1 
ATOM   9910  O  O     . GLY B 1 751 ? 137.565 78.550  121.431 1.00 101.99 ? 743 GLY B O     1 
ATOM   9911  N  N     . PHE B 1 752 ? 139.811 78.321  121.369 1.00 101.61 ? 744 PHE B N     1 
ATOM   9912  C  CA    . PHE B 1 752 ? 139.925 78.143  122.813 1.00 102.45 ? 744 PHE B CA    1 
ATOM   9913  C  C     . PHE B 1 752 ? 139.493 79.386  123.581 1.00 103.09 ? 744 PHE B C     1 
ATOM   9914  O  O     . PHE B 1 752 ? 138.877 79.270  124.646 1.00 103.06 ? 744 PHE B O     1 
ATOM   9915  C  CB    . PHE B 1 752 ? 141.360 77.766  123.181 1.00 101.59 ? 744 PHE B CB    1 
ATOM   9916  C  CG    . PHE B 1 752 ? 141.536 77.378  124.622 1.00 107.01 ? 744 PHE B CG    1 
ATOM   9917  C  CD1   . PHE B 1 752 ? 141.278 76.083  125.040 1.00 110.50 ? 744 PHE B CD1   1 
ATOM   9918  C  CD2   . PHE B 1 752 ? 141.964 78.306  125.557 1.00 107.63 ? 744 PHE B CD2   1 
ATOM   9919  C  CE1   . PHE B 1 752 ? 141.439 75.721  126.364 1.00 111.67 ? 744 PHE B CE1   1 
ATOM   9920  C  CE2   . PHE B 1 752 ? 142.126 77.950  126.883 1.00 107.41 ? 744 PHE B CE2   1 
ATOM   9921  C  CZ    . PHE B 1 752 ? 141.864 76.656  127.286 1.00 108.76 ? 744 PHE B CZ    1 
ATOM   9922  N  N     . ALA B 1 753 ? 139.808 80.576  123.068 1.00 100.24 ? 745 ALA B N     1 
ATOM   9923  C  CA    . ALA B 1 753 ? 139.502 81.810  123.783 1.00 96.64  ? 745 ALA B CA    1 
ATOM   9924  C  C     . ALA B 1 753 ? 138.010 82.093  123.881 1.00 95.05  ? 745 ALA B C     1 
ATOM   9925  O  O     . ALA B 1 753 ? 137.617 82.963  124.665 1.00 90.03  ? 745 ALA B O     1 
ATOM   9926  C  CB    . ALA B 1 753 ? 140.206 82.991  123.113 1.00 93.67  ? 745 ALA B CB    1 
ATOM   9927  N  N     . ALA B 1 754 ? 137.173 81.391  123.116 1.00 96.87  ? 746 ALA B N     1 
ATOM   9928  C  CA    . ALA B 1 754 ? 135.737 81.641  123.092 1.00 95.90  ? 746 ALA B CA    1 
ATOM   9929  C  C     . ALA B 1 754 ? 134.930 80.482  123.666 1.00 96.75  ? 746 ALA B C     1 
ATOM   9930  O  O     . ALA B 1 754 ? 133.736 80.362  123.377 1.00 97.76  ? 746 ALA B O     1 
ATOM   9931  C  CB    . ALA B 1 754 ? 135.278 81.947  121.666 1.00 94.42  ? 746 ALA B CB    1 
ATOM   9932  N  N     . LEU B 1 755 ? 135.556 79.624  124.473 1.00 97.11  ? 747 LEU B N     1 
ATOM   9933  C  CA    . LEU B 1 755 ? 134.845 78.466  125.005 1.00 98.25  ? 747 LEU B CA    1 
ATOM   9934  C  C     . LEU B 1 755 ? 133.888 78.846  126.128 1.00 97.04  ? 747 LEU B C     1 
ATOM   9935  O  O     . LEU B 1 755 ? 132.854 78.193  126.304 1.00 98.39  ? 747 LEU B O     1 
ATOM   9936  C  CB    . LEU B 1 755 ? 135.843 77.417  125.495 1.00 99.65  ? 747 LEU B CB    1 
ATOM   9937  C  CG    . LEU B 1 755 ? 136.751 76.802  124.429 1.00 102.31 ? 747 LEU B CG    1 
ATOM   9938  C  CD1   . LEU B 1 755 ? 137.683 75.773  125.048 1.00 101.46 ? 747 LEU B CD1   1 
ATOM   9939  C  CD2   . LEU B 1 755 ? 135.925 76.180  123.314 1.00 102.31 ? 747 LEU B CD2   1 
ATOM   9940  N  N     . LYS B 1 756 ? 134.207 79.893  126.893 1.00 94.77  ? 748 LYS B N     1 
ATOM   9941  C  CA    . LYS B 1 756 ? 133.422 80.229  128.075 1.00 94.48  ? 748 LYS B CA    1 
ATOM   9942  C  C     . LYS B 1 756 ? 132.047 80.795  127.747 1.00 95.58  ? 748 LYS B C     1 
ATOM   9943  O  O     . LYS B 1 756 ? 131.224 80.930  128.658 1.00 96.24  ? 748 LYS B O     1 
ATOM   9944  C  CB    . LYS B 1 756 ? 134.190 81.220  128.949 1.00 91.66  ? 748 LYS B CB    1 
ATOM   9945  C  CG    . LYS B 1 756 ? 134.618 82.487  128.237 1.00 86.73  ? 748 LYS B CG    1 
ATOM   9946  C  CD    . LYS B 1 756 ? 135.456 83.360  129.154 1.00 88.10  ? 748 LYS B CD    1 
ATOM   9947  C  CE    . LYS B 1 756 ? 136.003 84.571  128.423 1.00 87.44  ? 748 LYS B CE    1 
ATOM   9948  N  NZ    . LYS B 1 756 ? 136.864 85.407  129.305 1.00 91.35  ? 748 LYS B NZ    1 
ATOM   9949  N  N     . TYR B 1 757 ? 131.776 81.130  126.488 1.00 98.39  ? 749 TYR B N     1 
ATOM   9950  C  CA    . TYR B 1 757 ? 130.484 81.683  126.105 1.00 97.74  ? 749 TYR B CA    1 
ATOM   9951  C  C     . TYR B 1 757 ? 129.450 80.618  125.771 1.00 103.81 ? 749 TYR B C     1 
ATOM   9952  O  O     . TYR B 1 757 ? 128.284 80.961  125.548 1.00 103.22 ? 749 TYR B O     1 
ATOM   9953  C  CB    . TYR B 1 757 ? 130.647 82.621  124.906 1.00 89.17  ? 749 TYR B CB    1 
ATOM   9954  C  CG    . TYR B 1 757 ? 131.748 83.635  125.079 1.00 84.02  ? 749 TYR B CG    1 
ATOM   9955  C  CD1   . TYR B 1 757 ? 131.547 84.783  125.827 1.00 80.17  ? 749 TYR B CD1   1 
ATOM   9956  C  CD2   . TYR B 1 757 ? 132.989 83.442  124.495 1.00 86.01  ? 749 TYR B CD2   1 
ATOM   9957  C  CE1   . TYR B 1 757 ? 132.552 85.712  125.989 1.00 80.05  ? 749 TYR B CE1   1 
ATOM   9958  C  CE2   . TYR B 1 757 ? 134.000 84.365  124.650 1.00 85.30  ? 749 TYR B CE2   1 
ATOM   9959  C  CZ    . TYR B 1 757 ? 133.777 85.498  125.398 1.00 82.74  ? 749 TYR B CZ    1 
ATOM   9960  O  OH    . TYR B 1 757 ? 134.785 86.421  125.553 1.00 82.50  ? 749 TYR B OH    1 
ATOM   9961  N  N     . LEU B 1 758 ? 129.845 79.344  125.724 1.00 106.47 ? 750 LEU B N     1 
ATOM   9962  C  CA    . LEU B 1 758 ? 128.896 78.287  125.392 1.00 108.27 ? 750 LEU B CA    1 
ATOM   9963  C  C     . LEU B 1 758 ? 127.818 78.150  126.460 1.00 111.21 ? 750 LEU B C     1 
ATOM   9964  O  O     . LEU B 1 758 ? 126.646 77.919  126.142 1.00 110.90 ? 750 LEU B O     1 
ATOM   9965  C  CB    . LEU B 1 758 ? 129.633 76.962  125.199 1.00 105.05 ? 750 LEU B CB    1 
ATOM   9966  C  CG    . LEU B 1 758 ? 130.699 76.939  124.103 1.00 104.66 ? 750 LEU B CG    1 
ATOM   9967  C  CD1   . LEU B 1 758 ? 131.307 75.550  123.977 1.00 104.42 ? 750 LEU B CD1   1 
ATOM   9968  C  CD2   . LEU B 1 758 ? 130.117 77.397  122.776 1.00 104.50 ? 750 LEU B CD2   1 
ATOM   9969  N  N     . THR B 1 759 ? 128.193 78.289  127.729 1.00 111.91 ? 751 THR B N     1 
ATOM   9970  C  CA    . THR B 1 759 ? 127.259 78.154  128.838 1.00 114.53 ? 751 THR B CA    1 
ATOM   9971  C  C     . THR B 1 759 ? 126.538 79.454  129.168 1.00 114.01 ? 751 THR B C     1 
ATOM   9972  O  O     . THR B 1 759 ? 125.734 79.478  130.106 1.00 110.97 ? 751 THR B O     1 
ATOM   9973  C  CB    . THR B 1 759 ? 127.988 77.643  130.085 1.00 113.72 ? 751 THR B CB    1 
ATOM   9974  O  OG1   . THR B 1 759 ? 129.032 78.558  130.440 1.00 110.35 ? 751 THR B OG1   1 
ATOM   9975  C  CG2   . THR B 1 759 ? 128.590 76.271  129.824 1.00 112.34 ? 751 THR B CG2   1 
ATOM   9976  N  N     . ALA B 1 760 ? 126.805 80.528  128.432 1.00 116.00 ? 752 ALA B N     1 
ATOM   9977  C  CA    . ALA B 1 760 ? 126.153 81.809  128.675 1.00 116.78 ? 752 ALA B CA    1 
ATOM   9978  C  C     . ALA B 1 760 ? 124.662 81.737  128.363 1.00 119.50 ? 752 ALA B C     1 
ATOM   9979  O  O     . ALA B 1 760 ? 124.214 80.884  127.597 1.00 122.97 ? 752 ALA B O     1 
ATOM   9980  C  CB    . ALA B 1 760 ? 126.813 82.904  127.852 1.00 108.21 ? 752 ALA B CB    1 
HETATM 9981  MN MN    . MN  C 2 .   ? 96.563  110.508 125.170 1.00 69.81  ? 900 MN  A MN    1 
HETATM 9982  N  N1    . UDP D 3 .   ? 96.739  109.990 118.299 1.00 19.77  ? 901 UDP A N1    1 
HETATM 9983  C  C2    . UDP D 3 .   ? 97.457  108.967 117.715 1.00 19.77  ? 901 UDP A C2    1 
HETATM 9984  N  N3    . UDP D 3 .   ? 98.671  109.335 117.195 1.00 19.77  ? 901 UDP A N3    1 
HETATM 9985  C  C4    . UDP D 3 .   ? 99.224  110.599 117.197 1.00 19.77  ? 901 UDP A C4    1 
HETATM 9986  C  C5    . UDP D 3 .   ? 98.419  111.604 117.816 1.00 19.77  ? 901 UDP A C5    1 
HETATM 9987  C  C6    . UDP D 3 .   ? 97.224  111.277 118.334 1.00 19.77  ? 901 UDP A C6    1 
HETATM 9988  O  O2    . UDP D 3 .   ? 97.052  107.816 117.664 1.00 19.77  ? 901 UDP A O2    1 
HETATM 9989  O  O4    . UDP D 3 .   ? 100.338 110.781 116.684 1.00 19.77  ? 901 UDP A O4    1 
HETATM 9990  C  "C1'" . UDP D 3 .   ? 95.422  109.666 118.868 1.00 19.77  ? 901 UDP A "C1'" 1 
HETATM 9991  C  "C2'" . UDP D 3 .   ? 95.474  108.729 120.073 1.00 19.77  ? 901 UDP A "C2'" 1 
HETATM 9992  O  "O2'" . UDP D 3 .   ? 94.238  108.039 120.209 1.00 19.77  ? 901 UDP A "O2'" 1 
HETATM 9993  C  "C3'" . UDP D 3 .   ? 95.683  109.723 121.212 1.00 19.77  ? 901 UDP A "C3'" 1 
HETATM 9994  C  "C4'" . UDP D 3 .   ? 94.848  110.919 120.765 1.00 19.77  ? 901 UDP A "C4'" 1 
HETATM 9995  O  "O4'" . UDP D 3 .   ? 94.830  110.868 119.321 1.00 19.77  ? 901 UDP A "O4'" 1 
HETATM 9996  O  "O3'" . UDP D 3 .   ? 95.209  109.216 122.453 1.00 19.77  ? 901 UDP A "O3'" 1 
HETATM 9997  C  "C5'" . UDP D 3 .   ? 95.368  112.261 121.213 1.00 19.77  ? 901 UDP A "C5'" 1 
HETATM 9998  O  "O5'" . UDP D 3 .   ? 96.006  112.108 122.498 1.00 19.77  ? 901 UDP A "O5'" 1 
HETATM 9999  P  PA    . UDP D 3 .   ? 97.572  112.252 122.660 1.00 19.77  ? 901 UDP A PA    1 
HETATM 10000 O  O1A   . UDP D 3 .   ? 97.917  113.650 122.310 1.00 19.77  ? 901 UDP A O1A   1 
HETATM 10001 O  O2A   . UDP D 3 .   ? 98.307  111.148 121.907 1.00 19.77  ? 901 UDP A O2A   1 
HETATM 10002 O  O3A   . UDP D 3 .   ? 97.837  111.992 124.196 1.00 19.77  ? 901 UDP A O3A   1 
HETATM 10003 P  PB    . UDP D 3 .   ? 97.243  112.891 125.356 1.00 19.77  ? 901 UDP A PB    1 
HETATM 10004 O  O1B   . UDP D 3 .   ? 95.760  112.518 125.358 1.00 19.77  ? 901 UDP A O1B   1 
HETATM 10005 O  O2B   . UDP D 3 .   ? 97.917  112.329 126.604 1.00 19.77  ? 901 UDP A O2B   1 
HETATM 10006 O  O3B   . UDP D 3 .   ? 97.503  114.341 125.130 1.00 19.77  ? 901 UDP A O3B   1 
HETATM 10007 MN MN    . MN  E 2 .   ? 115.204 101.160 125.133 1.00 69.81  ? 801 MN  B MN    1 
HETATM 10008 N  N1    . UDP F 3 .   ? 115.027 101.678 118.262 1.00 19.77  ? 802 UDP B N1    1 
HETATM 10009 C  C2    . UDP F 3 .   ? 114.303 102.696 117.678 1.00 19.77  ? 802 UDP B C2    1 
HETATM 10010 N  N3    . UDP F 3 .   ? 113.091 102.321 117.158 1.00 19.77  ? 802 UDP B N3    1 
HETATM 10011 C  C4    . UDP F 3 .   ? 112.546 101.054 117.159 1.00 19.77  ? 802 UDP B C4    1 
HETATM 10012 C  C5    . UDP F 3 .   ? 113.357 100.053 117.778 1.00 19.77  ? 802 UDP B C5    1 
HETATM 10013 C  C6    . UDP F 3 .   ? 114.549 100.388 118.297 1.00 19.77  ? 802 UDP B C6    1 
HETATM 10014 O  O2    . UDP F 3 .   ? 114.700 103.851 117.627 1.00 19.77  ? 802 UDP B O2    1 
HETATM 10015 O  O4    . UDP F 3 .   ? 111.433 100.865 116.645 1.00 19.77  ? 802 UDP B O4    1 
HETATM 10016 C  "C1'" . UDP F 3 .   ? 116.342 102.010 118.832 1.00 19.77  ? 802 UDP B "C1'" 1 
HETATM 10017 C  "C2'" . UDP F 3 .   ? 116.283 102.946 120.036 1.00 19.77  ? 802 UDP B "C2'" 1 
HETATM 10018 O  "O2'" . UDP F 3 .   ? 117.515 103.645 120.174 1.00 19.77  ? 802 UDP B "O2'" 1 
HETATM 10019 C  "C3'" . UDP F 3 .   ? 116.080 101.951 121.176 1.00 19.77  ? 802 UDP B "C3'" 1 
HETATM 10020 C  "C4'" . UDP F 3 .   ? 116.923 100.760 120.729 1.00 19.77  ? 802 UDP B "C4'" 1 
HETATM 10021 O  "O4'" . UDP F 3 .   ? 116.941 100.811 119.285 1.00 19.77  ? 802 UDP B "O4'" 1 
HETATM 10022 O  "O3'" . UDP F 3 .   ? 116.551 102.460 122.417 1.00 19.77  ? 802 UDP B "O3'" 1 
HETATM 10023 C  "C5'" . UDP F 3 .   ? 116.411 99.415  121.176 1.00 19.77  ? 802 UDP B "C5'" 1 
HETATM 10024 O  "O5'" . UDP F 3 .   ? 115.771 99.564  122.460 1.00 19.77  ? 802 UDP B "O5'" 1 
HETATM 10025 P  PA    . UDP F 3 .   ? 114.206 99.410  122.622 1.00 19.77  ? 802 UDP B PA    1 
HETATM 10026 O  O1A   . UDP F 3 .   ? 113.870 98.010  122.272 1.00 19.77  ? 802 UDP B O1A   1 
HETATM 10027 O  O2A   . UDP F 3 .   ? 113.464 100.510 121.869 1.00 19.77  ? 802 UDP B O2A   1 
HETATM 10028 O  O3A   . UDP F 3 .   ? 113.939 99.668  124.158 1.00 19.77  ? 802 UDP B O3A   1 
HETATM 10029 P  PB    . UDP F 3 .   ? 114.538 98.772  125.319 1.00 19.77  ? 802 UDP B PB    1 
HETATM 10030 O  O1B   . UDP F 3 .   ? 116.019 99.155  125.321 1.00 19.77  ? 802 UDP B O1B   1 
HETATM 10031 O  O2B   . UDP F 3 .   ? 113.860 99.330  126.566 1.00 19.77  ? 802 UDP B O2B   1 
HETATM 10032 O  O3B   . UDP F 3 .   ? 114.287 97.320  125.092 1.00 19.77  ? 802 UDP B O3B   1 
# 
