data_9DZ5
# 
_entry.id   9DZ5 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DZ5         pdb_00009dz5 10.2210/pdb9dz5/pdb 
WWPDB D_1000289141 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-23 ? 
2 'Structure model' 1 1 2025-05-07 ? 
3 'Structure model' 1 2 2025-05-14 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.pdbx_database_id_DOI'    
8  2 'Structure model' '_citation.title'                   
9  2 'Structure model' '_citation.year'                    
10 3 'Structure model' '_citation.page_last'               
11 3 'Structure model' '_citation.pdbx_database_id_PubMed' 
12 3 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DZ5 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 8FSE unspecified 
PDB . 8T0D unspecified 
PDB . 8FTB unspecified 
PDB . 9C1T unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jinhua.wu@fccc.edu 
_pdbx_contact_author.name_first         Jinhua 
_pdbx_contact_author.name_last          Wu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5913-0633 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wu, J.'  1 0000-0001-5913-0633 
'Gao, T.' 2 0000-0002-6879-7680 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Rep' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2211-1247 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            44 
_citation.language                  ? 
_citation.page_first                115607 
_citation.page_last                 115607 
_citation.title                     
'Molecular basis of beta 2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.celrep.2025.115607 
_citation.pdbx_database_id_PubMed   40310722 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gao, T.'          1 ? 
primary 'Maskalenko, N.A.' 2 ? 
primary 'Kabir, S.'        3 ? 
primary 'Campbell, K.S.'   4 ? 
primary 'Wu, J.'           5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Talin-1 47448.574 1   ? D397R ? ? 
2 water   nat water   18.015    658 ? ?     ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNNDNPLFKSAMVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALD
YYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDELNWLDHGRT
LREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGF
LDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMR
VDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIRIILKKKKSKDHFGLEGDEESTM
LEDSVSPKKST
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNNDNPLFKSAMVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALD
YYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDELNWLDHGRT
LREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGF
LDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMR
VDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIRIILKKKKSKDHFGLEGDEESTM
LEDSVSPKKST
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   ASN n 
1 4   ASP n 
1 5   ASN n 
1 6   PRO n 
1 7   LEU n 
1 8   PHE n 
1 9   LYS n 
1 10  SER n 
1 11  ALA n 
1 12  MET n 
1 13  VAL n 
1 14  ALA n 
1 15  LEU n 
1 16  SER n 
1 17  LEU n 
1 18  LYS n 
1 19  ILE n 
1 20  SER n 
1 21  ILE n 
1 22  GLY n 
1 23  ASN n 
1 24  VAL n 
1 25  VAL n 
1 26  LYS n 
1 27  THR n 
1 28  MET n 
1 29  GLN n 
1 30  PHE n 
1 31  GLU n 
1 32  PRO n 
1 33  SER n 
1 34  THR n 
1 35  MET n 
1 36  VAL n 
1 37  TYR n 
1 38  ASP n 
1 39  ALA n 
1 40  CYS n 
1 41  ARG n 
1 42  MET n 
1 43  ILE n 
1 44  ARG n 
1 45  GLU n 
1 46  ARG n 
1 47  ILE n 
1 48  PRO n 
1 49  GLU n 
1 50  ALA n 
1 51  LEU n 
1 52  ALA n 
1 53  GLY n 
1 54  PRO n 
1 55  PRO n 
1 56  ASN n 
1 57  ASP n 
1 58  PHE n 
1 59  GLY n 
1 60  LEU n 
1 61  PHE n 
1 62  LEU n 
1 63  SER n 
1 64  ASP n 
1 65  ASP n 
1 66  ASP n 
1 67  PRO n 
1 68  LYS n 
1 69  LYS n 
1 70  GLY n 
1 71  ILE n 
1 72  TRP n 
1 73  LEU n 
1 74  GLU n 
1 75  ALA n 
1 76  GLY n 
1 77  LYS n 
1 78  ALA n 
1 79  LEU n 
1 80  ASP n 
1 81  TYR n 
1 82  TYR n 
1 83  MET n 
1 84  LEU n 
1 85  ARG n 
1 86  ASN n 
1 87  GLY n 
1 88  ASP n 
1 89  THR n 
1 90  MET n 
1 91  GLU n 
1 92  TYR n 
1 93  ARG n 
1 94  LYS n 
1 95  LYS n 
1 96  GLN n 
1 97  ARG n 
1 98  PRO n 
1 99  LEU n 
1 100 LYS n 
1 101 ILE n 
1 102 ARG n 
1 103 MET n 
1 104 LEU n 
1 105 ASP n 
1 106 GLY n 
1 107 THR n 
1 108 VAL n 
1 109 LYS n 
1 110 THR n 
1 111 ILE n 
1 112 MET n 
1 113 VAL n 
1 114 ASP n 
1 115 ASP n 
1 116 SER n 
1 117 LYS n 
1 118 THR n 
1 119 VAL n 
1 120 THR n 
1 121 ASP n 
1 122 MET n 
1 123 LEU n 
1 124 MET n 
1 125 THR n 
1 126 ILE n 
1 127 CYS n 
1 128 ALA n 
1 129 ARG n 
1 130 ILE n 
1 131 GLY n 
1 132 ILE n 
1 133 THR n 
1 134 ASN n 
1 135 HIS n 
1 136 ASP n 
1 137 GLU n 
1 138 TYR n 
1 139 SER n 
1 140 LEU n 
1 141 VAL n 
1 142 ARG n 
1 143 GLU n 
1 144 LEU n 
1 145 MET n 
1 146 GLU n 
1 147 GLU n 
1 148 LYS n 
1 149 LYS n 
1 150 ASP n 
1 151 GLU n 
1 152 LEU n 
1 153 ASN n 
1 154 TRP n 
1 155 LEU n 
1 156 ASP n 
1 157 HIS n 
1 158 GLY n 
1 159 ARG n 
1 160 THR n 
1 161 LEU n 
1 162 ARG n 
1 163 GLU n 
1 164 GLN n 
1 165 GLY n 
1 166 VAL n 
1 167 GLU n 
1 168 GLU n 
1 169 HIS n 
1 170 GLU n 
1 171 THR n 
1 172 LEU n 
1 173 LEU n 
1 174 LEU n 
1 175 ARG n 
1 176 ARG n 
1 177 LYS n 
1 178 PHE n 
1 179 PHE n 
1 180 TYR n 
1 181 SER n 
1 182 ASP n 
1 183 GLN n 
1 184 ASN n 
1 185 VAL n 
1 186 ASP n 
1 187 SER n 
1 188 ARG n 
1 189 ASP n 
1 190 PRO n 
1 191 VAL n 
1 192 GLN n 
1 193 LEU n 
1 194 ASN n 
1 195 LEU n 
1 196 LEU n 
1 197 TYR n 
1 198 VAL n 
1 199 GLN n 
1 200 ALA n 
1 201 ARG n 
1 202 ASP n 
1 203 ASP n 
1 204 ILE n 
1 205 LEU n 
1 206 ASN n 
1 207 GLY n 
1 208 SER n 
1 209 HIS n 
1 210 PRO n 
1 211 VAL n 
1 212 SER n 
1 213 PHE n 
1 214 ASP n 
1 215 LYS n 
1 216 ALA n 
1 217 CYS n 
1 218 GLU n 
1 219 PHE n 
1 220 ALA n 
1 221 GLY n 
1 222 PHE n 
1 223 GLN n 
1 224 CYS n 
1 225 GLN n 
1 226 ILE n 
1 227 GLN n 
1 228 PHE n 
1 229 GLY n 
1 230 PRO n 
1 231 HIS n 
1 232 ASN n 
1 233 GLU n 
1 234 GLN n 
1 235 LYS n 
1 236 HIS n 
1 237 LYS n 
1 238 ALA n 
1 239 GLY n 
1 240 PHE n 
1 241 LEU n 
1 242 ASP n 
1 243 LEU n 
1 244 LYS n 
1 245 ASP n 
1 246 PHE n 
1 247 LEU n 
1 248 PRO n 
1 249 LYS n 
1 250 GLU n 
1 251 TYR n 
1 252 VAL n 
1 253 LYS n 
1 254 GLN n 
1 255 LYS n 
1 256 GLY n 
1 257 GLU n 
1 258 ARG n 
1 259 LYS n 
1 260 ILE n 
1 261 PHE n 
1 262 GLN n 
1 263 ALA n 
1 264 HIS n 
1 265 LYS n 
1 266 ASN n 
1 267 CYS n 
1 268 GLY n 
1 269 GLN n 
1 270 MET n 
1 271 SER n 
1 272 GLU n 
1 273 ILE n 
1 274 GLU n 
1 275 ALA n 
1 276 LYS n 
1 277 VAL n 
1 278 ARG n 
1 279 TYR n 
1 280 VAL n 
1 281 LYS n 
1 282 LEU n 
1 283 ALA n 
1 284 ARG n 
1 285 SER n 
1 286 LEU n 
1 287 LYS n 
1 288 THR n 
1 289 TYR n 
1 290 GLY n 
1 291 VAL n 
1 292 SER n 
1 293 PHE n 
1 294 PHE n 
1 295 LEU n 
1 296 VAL n 
1 297 LYS n 
1 298 GLU n 
1 299 LYS n 
1 300 MET n 
1 301 LYS n 
1 302 GLY n 
1 303 LYS n 
1 304 ASN n 
1 305 LYS n 
1 306 LEU n 
1 307 VAL n 
1 308 PRO n 
1 309 ARG n 
1 310 LEU n 
1 311 LEU n 
1 312 GLY n 
1 313 ILE n 
1 314 THR n 
1 315 LYS n 
1 316 GLU n 
1 317 CYS n 
1 318 VAL n 
1 319 MET n 
1 320 ARG n 
1 321 VAL n 
1 322 ASP n 
1 323 GLU n 
1 324 LYS n 
1 325 THR n 
1 326 LYS n 
1 327 GLU n 
1 328 VAL n 
1 329 ILE n 
1 330 GLN n 
1 331 GLU n 
1 332 TRP n 
1 333 SER n 
1 334 LEU n 
1 335 THR n 
1 336 ASN n 
1 337 ILE n 
1 338 LYS n 
1 339 ARG n 
1 340 TRP n 
1 341 ALA n 
1 342 ALA n 
1 343 SER n 
1 344 PRO n 
1 345 LYS n 
1 346 SER n 
1 347 PHE n 
1 348 THR n 
1 349 LEU n 
1 350 ASP n 
1 351 PHE n 
1 352 GLY n 
1 353 ASP n 
1 354 TYR n 
1 355 GLN n 
1 356 ASP n 
1 357 GLY n 
1 358 TYR n 
1 359 TYR n 
1 360 SER n 
1 361 VAL n 
1 362 GLN n 
1 363 THR n 
1 364 THR n 
1 365 GLU n 
1 366 GLY n 
1 367 GLU n 
1 368 GLN n 
1 369 ILE n 
1 370 ALA n 
1 371 GLN n 
1 372 LEU n 
1 373 ILE n 
1 374 ALA n 
1 375 GLY n 
1 376 TYR n 
1 377 ILE n 
1 378 ARG n 
1 379 ILE n 
1 380 ILE n 
1 381 LEU n 
1 382 LYS n 
1 383 LYS n 
1 384 LYS n 
1 385 LYS n 
1 386 SER n 
1 387 LYS n 
1 388 ASP n 
1 389 HIS n 
1 390 PHE n 
1 391 GLY n 
1 392 LEU n 
1 393 GLU n 
1 394 GLY n 
1 395 ASP n 
1 396 GLU n 
1 397 GLU n 
1 398 SER n 
1 399 THR n 
1 400 MET n 
1 401 LEU n 
1 402 GLU n 
1 403 ASP n 
1 404 SER n 
1 405 VAL n 
1 406 SER n 
1 407 PRO n 
1 408 LYS n 
1 409 LYS n 
1 410 SER n 
1 411 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   411 
_entity_src_gen.gene_src_common_name               'house mouse' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Tln1, Tln' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Mus musculus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10090 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -10 ?   ?   ?   A . n 
A 1 2   ASN 2   -9  ?   ?   ?   A . n 
A 1 3   ASN 3   -8  -8  ASN ASN A . n 
A 1 4   ASP 4   -7  -7  ASP ASP A . n 
A 1 5   ASN 5   -6  -6  ASN ASN A . n 
A 1 6   PRO 6   -5  -5  PRO PRO A . n 
A 1 7   LEU 7   -4  -4  LEU LEU A . n 
A 1 8   PHE 8   -3  -3  PHE PHE A . n 
A 1 9   LYS 9   -2  -2  LYS LYS A . n 
A 1 10  SER 10  -1  -1  SER SER A . n 
A 1 11  ALA 11  0   0   ALA ALA A . n 
A 1 12  MET 12  1   1   MET MET A . n 
A 1 13  VAL 13  2   2   VAL VAL A . n 
A 1 14  ALA 14  3   3   ALA ALA A . n 
A 1 15  LEU 15  4   4   LEU LEU A . n 
A 1 16  SER 16  5   5   SER SER A . n 
A 1 17  LEU 17  6   6   LEU LEU A . n 
A 1 18  LYS 18  7   7   LYS LYS A . n 
A 1 19  ILE 19  8   8   ILE ILE A . n 
A 1 20  SER 20  9   9   SER SER A . n 
A 1 21  ILE 21  10  10  ILE ILE A . n 
A 1 22  GLY 22  11  11  GLY GLY A . n 
A 1 23  ASN 23  12  12  ASN ASN A . n 
A 1 24  VAL 24  13  13  VAL VAL A . n 
A 1 25  VAL 25  14  14  VAL VAL A . n 
A 1 26  LYS 26  15  15  LYS LYS A . n 
A 1 27  THR 27  16  16  THR THR A . n 
A 1 28  MET 28  17  17  MET MET A . n 
A 1 29  GLN 29  18  18  GLN GLN A . n 
A 1 30  PHE 30  19  19  PHE PHE A . n 
A 1 31  GLU 31  20  20  GLU GLU A . n 
A 1 32  PRO 32  21  21  PRO PRO A . n 
A 1 33  SER 33  22  22  SER SER A . n 
A 1 34  THR 34  23  23  THR THR A . n 
A 1 35  MET 35  24  24  MET MET A . n 
A 1 36  VAL 36  25  25  VAL VAL A . n 
A 1 37  TYR 37  26  26  TYR TYR A . n 
A 1 38  ASP 38  27  27  ASP ASP A . n 
A 1 39  ALA 39  28  28  ALA ALA A . n 
A 1 40  CYS 40  29  29  CYS CYS A . n 
A 1 41  ARG 41  30  30  ARG ARG A . n 
A 1 42  MET 42  31  31  MET MET A . n 
A 1 43  ILE 43  32  32  ILE ILE A . n 
A 1 44  ARG 44  33  33  ARG ARG A . n 
A 1 45  GLU 45  34  34  GLU GLU A . n 
A 1 46  ARG 46  35  35  ARG ARG A . n 
A 1 47  ILE 47  36  36  ILE ILE A . n 
A 1 48  PRO 48  37  37  PRO PRO A . n 
A 1 49  GLU 49  38  38  GLU GLU A . n 
A 1 50  ALA 50  39  39  ALA ALA A . n 
A 1 51  LEU 51  40  40  LEU LEU A . n 
A 1 52  ALA 52  41  41  ALA ALA A . n 
A 1 53  GLY 53  42  42  GLY GLY A . n 
A 1 54  PRO 54  43  43  PRO PRO A . n 
A 1 55  PRO 55  44  44  PRO PRO A . n 
A 1 56  ASN 56  45  45  ASN ASN A . n 
A 1 57  ASP 57  46  46  ASP ASP A . n 
A 1 58  PHE 58  47  47  PHE PHE A . n 
A 1 59  GLY 59  48  48  GLY GLY A . n 
A 1 60  LEU 60  49  49  LEU LEU A . n 
A 1 61  PHE 61  50  50  PHE PHE A . n 
A 1 62  LEU 62  51  51  LEU LEU A . n 
A 1 63  SER 63  52  52  SER SER A . n 
A 1 64  ASP 64  53  53  ASP ASP A . n 
A 1 65  ASP 65  54  54  ASP ASP A . n 
A 1 66  ASP 66  55  55  ASP ASP A . n 
A 1 67  PRO 67  56  56  PRO PRO A . n 
A 1 68  LYS 68  57  57  LYS LYS A . n 
A 1 69  LYS 69  58  58  LYS LYS A . n 
A 1 70  GLY 70  59  59  GLY GLY A . n 
A 1 71  ILE 71  60  60  ILE ILE A . n 
A 1 72  TRP 72  61  61  TRP TRP A . n 
A 1 73  LEU 73  62  62  LEU LEU A . n 
A 1 74  GLU 74  63  63  GLU GLU A . n 
A 1 75  ALA 75  64  64  ALA ALA A . n 
A 1 76  GLY 76  65  65  GLY GLY A . n 
A 1 77  LYS 77  66  66  LYS LYS A . n 
A 1 78  ALA 78  67  67  ALA ALA A . n 
A 1 79  LEU 79  68  68  LEU LEU A . n 
A 1 80  ASP 80  69  69  ASP ASP A . n 
A 1 81  TYR 81  70  70  TYR TYR A . n 
A 1 82  TYR 82  71  71  TYR TYR A . n 
A 1 83  MET 83  72  72  MET MET A . n 
A 1 84  LEU 84  73  73  LEU LEU A . n 
A 1 85  ARG 85  74  74  ARG ARG A . n 
A 1 86  ASN 86  75  75  ASN ASN A . n 
A 1 87  GLY 87  76  76  GLY GLY A . n 
A 1 88  ASP 88  77  77  ASP ASP A . n 
A 1 89  THR 89  78  78  THR THR A . n 
A 1 90  MET 90  79  79  MET MET A . n 
A 1 91  GLU 91  80  80  GLU GLU A . n 
A 1 92  TYR 92  81  81  TYR TYR A . n 
A 1 93  ARG 93  82  82  ARG ARG A . n 
A 1 94  LYS 94  83  83  LYS LYS A . n 
A 1 95  LYS 95  84  84  LYS LYS A . n 
A 1 96  GLN 96  85  85  GLN GLN A . n 
A 1 97  ARG 97  86  86  ARG ARG A . n 
A 1 98  PRO 98  87  87  PRO PRO A . n 
A 1 99  LEU 99  88  88  LEU LEU A . n 
A 1 100 LYS 100 89  89  LYS LYS A . n 
A 1 101 ILE 101 90  90  ILE ILE A . n 
A 1 102 ARG 102 91  91  ARG ARG A . n 
A 1 103 MET 103 92  92  MET MET A . n 
A 1 104 LEU 104 93  93  LEU LEU A . n 
A 1 105 ASP 105 94  94  ASP ASP A . n 
A 1 106 GLY 106 95  95  GLY GLY A . n 
A 1 107 THR 107 96  96  THR THR A . n 
A 1 108 VAL 108 97  97  VAL VAL A . n 
A 1 109 LYS 109 98  98  LYS LYS A . n 
A 1 110 THR 110 99  99  THR THR A . n 
A 1 111 ILE 111 100 100 ILE ILE A . n 
A 1 112 MET 112 101 101 MET MET A . n 
A 1 113 VAL 113 102 102 VAL VAL A . n 
A 1 114 ASP 114 103 103 ASP ASP A . n 
A 1 115 ASP 115 104 104 ASP ASP A . n 
A 1 116 SER 116 105 105 SER SER A . n 
A 1 117 LYS 117 106 106 LYS LYS A . n 
A 1 118 THR 118 107 107 THR THR A . n 
A 1 119 VAL 119 108 108 VAL VAL A . n 
A 1 120 THR 120 109 109 THR THR A . n 
A 1 121 ASP 121 110 110 ASP ASP A . n 
A 1 122 MET 122 111 111 MET MET A . n 
A 1 123 LEU 123 112 112 LEU LEU A . n 
A 1 124 MET 124 113 113 MET MET A . n 
A 1 125 THR 125 114 114 THR THR A . n 
A 1 126 ILE 126 115 115 ILE ILE A . n 
A 1 127 CYS 127 116 116 CYS CYS A . n 
A 1 128 ALA 128 117 117 ALA ALA A . n 
A 1 129 ARG 129 118 118 ARG ARG A . n 
A 1 130 ILE 130 119 119 ILE ILE A . n 
A 1 131 GLY 131 120 120 GLY GLY A . n 
A 1 132 ILE 132 121 121 ILE ILE A . n 
A 1 133 THR 133 122 122 THR THR A . n 
A 1 134 ASN 134 123 123 ASN ASN A . n 
A 1 135 HIS 135 124 124 HIS HIS A . n 
A 1 136 ASP 136 125 125 ASP ASP A . n 
A 1 137 GLU 137 126 126 GLU GLU A . n 
A 1 138 TYR 138 127 127 TYR TYR A . n 
A 1 139 SER 139 128 128 SER SER A . n 
A 1 140 LEU 140 129 129 LEU LEU A . n 
A 1 141 VAL 141 130 130 VAL VAL A . n 
A 1 142 ARG 142 131 131 ARG ARG A . n 
A 1 143 GLU 143 132 132 GLU GLU A . n 
A 1 144 LEU 144 133 133 LEU LEU A . n 
A 1 145 MET 145 134 134 MET MET A . n 
A 1 146 GLU 146 165 ?   ?   ?   A . n 
A 1 147 GLU 147 166 ?   ?   ?   A . n 
A 1 148 LYS 148 167 ?   ?   ?   A . n 
A 1 149 LYS 149 168 ?   ?   ?   A . n 
A 1 150 ASP 150 169 169 ASP ASP A . n 
A 1 151 GLU 151 170 170 GLU GLU A . n 
A 1 152 LEU 152 171 171 LEU LEU A . n 
A 1 153 ASN 153 172 172 ASN ASN A . n 
A 1 154 TRP 154 173 173 TRP TRP A . n 
A 1 155 LEU 155 174 174 LEU LEU A . n 
A 1 156 ASP 156 175 175 ASP ASP A . n 
A 1 157 HIS 157 176 176 HIS HIS A . n 
A 1 158 GLY 158 177 177 GLY GLY A . n 
A 1 159 ARG 159 178 178 ARG ARG A . n 
A 1 160 THR 160 179 179 THR THR A . n 
A 1 161 LEU 161 180 180 LEU LEU A . n 
A 1 162 ARG 162 181 181 ARG ARG A . n 
A 1 163 GLU 163 182 182 GLU GLU A . n 
A 1 164 GLN 164 183 183 GLN GLN A . n 
A 1 165 GLY 165 184 184 GLY GLY A . n 
A 1 166 VAL 166 185 185 VAL VAL A . n 
A 1 167 GLU 167 186 186 GLU GLU A . n 
A 1 168 GLU 168 187 187 GLU GLU A . n 
A 1 169 HIS 169 188 188 HIS HIS A . n 
A 1 170 GLU 170 189 189 GLU GLU A . n 
A 1 171 THR 171 190 190 THR THR A . n 
A 1 172 LEU 172 191 191 LEU LEU A . n 
A 1 173 LEU 173 192 192 LEU LEU A . n 
A 1 174 LEU 174 193 193 LEU LEU A . n 
A 1 175 ARG 175 194 194 ARG ARG A . n 
A 1 176 ARG 176 195 195 ARG ARG A . n 
A 1 177 LYS 177 196 196 LYS LYS A . n 
A 1 178 PHE 178 197 197 PHE PHE A . n 
A 1 179 PHE 179 198 198 PHE PHE A . n 
A 1 180 TYR 180 199 199 TYR TYR A . n 
A 1 181 SER 181 200 200 SER SER A . n 
A 1 182 ASP 182 201 201 ASP ASP A . n 
A 1 183 GLN 183 202 202 GLN GLN A . n 
A 1 184 ASN 184 203 203 ASN ASN A . n 
A 1 185 VAL 185 204 204 VAL VAL A . n 
A 1 186 ASP 186 205 205 ASP ASP A . n 
A 1 187 SER 187 206 206 SER SER A . n 
A 1 188 ARG 188 207 207 ARG ARG A . n 
A 1 189 ASP 189 208 208 ASP ASP A . n 
A 1 190 PRO 190 209 209 PRO PRO A . n 
A 1 191 VAL 191 210 210 VAL VAL A . n 
A 1 192 GLN 192 211 211 GLN GLN A . n 
A 1 193 LEU 193 212 212 LEU LEU A . n 
A 1 194 ASN 194 213 213 ASN ASN A . n 
A 1 195 LEU 195 214 214 LEU LEU A . n 
A 1 196 LEU 196 215 215 LEU LEU A . n 
A 1 197 TYR 197 216 216 TYR TYR A . n 
A 1 198 VAL 198 217 217 VAL VAL A . n 
A 1 199 GLN 199 218 218 GLN GLN A . n 
A 1 200 ALA 200 219 219 ALA ALA A . n 
A 1 201 ARG 201 220 220 ARG ARG A . n 
A 1 202 ASP 202 221 221 ASP ASP A . n 
A 1 203 ASP 203 222 222 ASP ASP A . n 
A 1 204 ILE 204 223 223 ILE ILE A . n 
A 1 205 LEU 205 224 224 LEU LEU A . n 
A 1 206 ASN 206 225 225 ASN ASN A . n 
A 1 207 GLY 207 226 226 GLY GLY A . n 
A 1 208 SER 208 227 227 SER SER A . n 
A 1 209 HIS 209 228 228 HIS HIS A . n 
A 1 210 PRO 210 229 229 PRO PRO A . n 
A 1 211 VAL 211 230 230 VAL VAL A . n 
A 1 212 SER 212 231 231 SER SER A . n 
A 1 213 PHE 213 232 232 PHE PHE A . n 
A 1 214 ASP 214 233 233 ASP ASP A . n 
A 1 215 LYS 215 234 234 LYS LYS A . n 
A 1 216 ALA 216 235 235 ALA ALA A . n 
A 1 217 CYS 217 236 236 CYS CYS A . n 
A 1 218 GLU 218 237 237 GLU GLU A . n 
A 1 219 PHE 219 238 238 PHE PHE A . n 
A 1 220 ALA 220 239 239 ALA ALA A . n 
A 1 221 GLY 221 240 240 GLY GLY A . n 
A 1 222 PHE 222 241 241 PHE PHE A . n 
A 1 223 GLN 223 242 242 GLN GLN A . n 
A 1 224 CYS 224 243 243 CYS CYS A . n 
A 1 225 GLN 225 244 244 GLN GLN A . n 
A 1 226 ILE 226 245 245 ILE ILE A . n 
A 1 227 GLN 227 246 246 GLN GLN A . n 
A 1 228 PHE 228 247 247 PHE PHE A . n 
A 1 229 GLY 229 248 248 GLY GLY A . n 
A 1 230 PRO 230 249 249 PRO PRO A . n 
A 1 231 HIS 231 250 250 HIS HIS A . n 
A 1 232 ASN 232 251 251 ASN ASN A . n 
A 1 233 GLU 233 252 252 GLU GLU A . n 
A 1 234 GLN 234 253 253 GLN GLN A . n 
A 1 235 LYS 235 254 254 LYS LYS A . n 
A 1 236 HIS 236 255 255 HIS HIS A . n 
A 1 237 LYS 237 256 256 LYS LYS A . n 
A 1 238 ALA 238 257 257 ALA ALA A . n 
A 1 239 GLY 239 258 258 GLY GLY A . n 
A 1 240 PHE 240 259 259 PHE PHE A . n 
A 1 241 LEU 241 260 260 LEU LEU A . n 
A 1 242 ASP 242 261 261 ASP ASP A . n 
A 1 243 LEU 243 262 262 LEU LEU A . n 
A 1 244 LYS 244 263 263 LYS LYS A . n 
A 1 245 ASP 245 264 264 ASP ASP A . n 
A 1 246 PHE 246 265 265 PHE PHE A . n 
A 1 247 LEU 247 266 266 LEU LEU A . n 
A 1 248 PRO 248 267 267 PRO PRO A . n 
A 1 249 LYS 249 268 268 LYS LYS A . n 
A 1 250 GLU 250 269 269 GLU GLU A . n 
A 1 251 TYR 251 270 270 TYR TYR A . n 
A 1 252 VAL 252 271 271 VAL VAL A . n 
A 1 253 LYS 253 272 272 LYS LYS A . n 
A 1 254 GLN 254 273 273 GLN GLN A . n 
A 1 255 LYS 255 274 274 LYS LYS A . n 
A 1 256 GLY 256 275 275 GLY GLY A . n 
A 1 257 GLU 257 276 276 GLU GLU A . n 
A 1 258 ARG 258 277 277 ARG ARG A . n 
A 1 259 LYS 259 278 278 LYS LYS A . n 
A 1 260 ILE 260 279 279 ILE ILE A . n 
A 1 261 PHE 261 280 280 PHE PHE A . n 
A 1 262 GLN 262 281 281 GLN GLN A . n 
A 1 263 ALA 263 282 282 ALA ALA A . n 
A 1 264 HIS 264 283 283 HIS HIS A . n 
A 1 265 LYS 265 284 284 LYS LYS A . n 
A 1 266 ASN 266 285 285 ASN ASN A . n 
A 1 267 CYS 267 286 286 CYS CYS A . n 
A 1 268 GLY 268 287 287 GLY GLY A . n 
A 1 269 GLN 269 288 288 GLN GLN A . n 
A 1 270 MET 270 289 289 MET MET A . n 
A 1 271 SER 271 290 290 SER SER A . n 
A 1 272 GLU 272 291 291 GLU GLU A . n 
A 1 273 ILE 273 292 292 ILE ILE A . n 
A 1 274 GLU 274 293 293 GLU GLU A . n 
A 1 275 ALA 275 294 294 ALA ALA A . n 
A 1 276 LYS 276 295 295 LYS LYS A . n 
A 1 277 VAL 277 296 296 VAL VAL A . n 
A 1 278 ARG 278 297 297 ARG ARG A . n 
A 1 279 TYR 279 298 298 TYR TYR A . n 
A 1 280 VAL 280 299 299 VAL VAL A . n 
A 1 281 LYS 281 300 300 LYS LYS A . n 
A 1 282 LEU 282 301 301 LEU LEU A . n 
A 1 283 ALA 283 302 302 ALA ALA A . n 
A 1 284 ARG 284 303 303 ARG ARG A . n 
A 1 285 SER 285 304 304 SER SER A . n 
A 1 286 LEU 286 305 305 LEU LEU A . n 
A 1 287 LYS 287 306 306 LYS LYS A . n 
A 1 288 THR 288 307 307 THR THR A . n 
A 1 289 TYR 289 308 308 TYR TYR A . n 
A 1 290 GLY 290 309 309 GLY GLY A . n 
A 1 291 VAL 291 310 310 VAL VAL A . n 
A 1 292 SER 292 311 311 SER SER A . n 
A 1 293 PHE 293 312 312 PHE PHE A . n 
A 1 294 PHE 294 313 313 PHE PHE A . n 
A 1 295 LEU 295 314 314 LEU LEU A . n 
A 1 296 VAL 296 315 315 VAL VAL A . n 
A 1 297 LYS 297 316 316 LYS LYS A . n 
A 1 298 GLU 298 317 317 GLU GLU A . n 
A 1 299 LYS 299 318 318 LYS LYS A . n 
A 1 300 MET 300 319 319 MET MET A . n 
A 1 301 LYS 301 320 320 LYS LYS A . n 
A 1 302 GLY 302 321 321 GLY GLY A . n 
A 1 303 LYS 303 322 322 LYS LYS A . n 
A 1 304 ASN 304 323 323 ASN ASN A . n 
A 1 305 LYS 305 324 324 LYS LYS A . n 
A 1 306 LEU 306 325 325 LEU LEU A . n 
A 1 307 VAL 307 326 326 VAL VAL A . n 
A 1 308 PRO 308 327 327 PRO PRO A . n 
A 1 309 ARG 309 328 328 ARG ARG A . n 
A 1 310 LEU 310 329 329 LEU LEU A . n 
A 1 311 LEU 311 330 330 LEU LEU A . n 
A 1 312 GLY 312 331 331 GLY GLY A . n 
A 1 313 ILE 313 332 332 ILE ILE A . n 
A 1 314 THR 314 333 333 THR THR A . n 
A 1 315 LYS 315 334 334 LYS LYS A . n 
A 1 316 GLU 316 335 335 GLU GLU A . n 
A 1 317 CYS 317 336 336 CYS CYS A . n 
A 1 318 VAL 318 337 337 VAL VAL A . n 
A 1 319 MET 319 338 338 MET MET A . n 
A 1 320 ARG 320 339 339 ARG ARG A . n 
A 1 321 VAL 321 340 340 VAL VAL A . n 
A 1 322 ASP 322 341 341 ASP ASP A . n 
A 1 323 GLU 323 342 342 GLU GLU A . n 
A 1 324 LYS 324 343 343 LYS LYS A . n 
A 1 325 THR 325 344 344 THR THR A . n 
A 1 326 LYS 326 345 345 LYS LYS A . n 
A 1 327 GLU 327 346 346 GLU GLU A . n 
A 1 328 VAL 328 347 347 VAL VAL A . n 
A 1 329 ILE 329 348 348 ILE ILE A . n 
A 1 330 GLN 330 349 349 GLN GLN A . n 
A 1 331 GLU 331 350 350 GLU GLU A . n 
A 1 332 TRP 332 351 351 TRP TRP A . n 
A 1 333 SER 333 352 352 SER SER A . n 
A 1 334 LEU 334 353 353 LEU LEU A . n 
A 1 335 THR 335 354 354 THR THR A . n 
A 1 336 ASN 336 355 355 ASN ASN A . n 
A 1 337 ILE 337 356 356 ILE ILE A . n 
A 1 338 LYS 338 357 357 LYS LYS A . n 
A 1 339 ARG 339 358 358 ARG ARG A . n 
A 1 340 TRP 340 359 359 TRP TRP A . n 
A 1 341 ALA 341 360 360 ALA ALA A . n 
A 1 342 ALA 342 361 361 ALA ALA A . n 
A 1 343 SER 343 362 362 SER SER A . n 
A 1 344 PRO 344 363 363 PRO PRO A . n 
A 1 345 LYS 345 364 364 LYS LYS A . n 
A 1 346 SER 346 365 365 SER SER A . n 
A 1 347 PHE 347 366 366 PHE PHE A . n 
A 1 348 THR 348 367 367 THR THR A . n 
A 1 349 LEU 349 368 368 LEU LEU A . n 
A 1 350 ASP 350 369 369 ASP ASP A . n 
A 1 351 PHE 351 370 370 PHE PHE A . n 
A 1 352 GLY 352 371 371 GLY GLY A . n 
A 1 353 ASP 353 372 372 ASP ASP A . n 
A 1 354 TYR 354 373 373 TYR TYR A . n 
A 1 355 GLN 355 374 374 GLN GLN A . n 
A 1 356 ASP 356 375 375 ASP ASP A . n 
A 1 357 GLY 357 376 376 GLY GLY A . n 
A 1 358 TYR 358 377 377 TYR TYR A . n 
A 1 359 TYR 359 378 378 TYR TYR A . n 
A 1 360 SER 360 379 379 SER SER A . n 
A 1 361 VAL 361 380 380 VAL VAL A . n 
A 1 362 GLN 362 381 381 GLN GLN A . n 
A 1 363 THR 363 382 382 THR THR A . n 
A 1 364 THR 364 383 383 THR THR A . n 
A 1 365 GLU 365 384 384 GLU GLU A . n 
A 1 366 GLY 366 385 385 GLY GLY A . n 
A 1 367 GLU 367 386 386 GLU GLU A . n 
A 1 368 GLN 368 387 387 GLN GLN A . n 
A 1 369 ILE 369 388 388 ILE ILE A . n 
A 1 370 ALA 370 389 389 ALA ALA A . n 
A 1 371 GLN 371 390 390 GLN GLN A . n 
A 1 372 LEU 372 391 391 LEU LEU A . n 
A 1 373 ILE 373 392 392 ILE ILE A . n 
A 1 374 ALA 374 393 393 ALA ALA A . n 
A 1 375 GLY 375 394 394 GLY GLY A . n 
A 1 376 TYR 376 395 395 TYR TYR A . n 
A 1 377 ILE 377 396 396 ILE ILE A . n 
A 1 378 ARG 378 397 397 ARG ARG A . n 
A 1 379 ILE 379 398 398 ILE ILE A . n 
A 1 380 ILE 380 399 399 ILE ILE A . n 
A 1 381 LEU 381 400 400 LEU LEU A . n 
A 1 382 LYS 382 401 401 LYS LYS A . n 
A 1 383 LYS 383 402 402 LYS LYS A . n 
A 1 384 LYS 384 403 403 LYS LYS A . n 
A 1 385 LYS 385 404 404 LYS LYS A . n 
A 1 386 SER 386 405 ?   ?   ?   A . n 
A 1 387 LYS 387 406 ?   ?   ?   A . n 
A 1 388 ASP 388 407 ?   ?   ?   A . n 
A 1 389 HIS 389 408 ?   ?   ?   A . n 
A 1 390 PHE 390 409 ?   ?   ?   A . n 
A 1 391 GLY 391 410 ?   ?   ?   A . n 
A 1 392 LEU 392 411 ?   ?   ?   A . n 
A 1 393 GLU 393 412 ?   ?   ?   A . n 
A 1 394 GLY 394 413 ?   ?   ?   A . n 
A 1 395 ASP 395 414 ?   ?   ?   A . n 
A 1 396 GLU 396 415 ?   ?   ?   A . n 
A 1 397 GLU 397 416 ?   ?   ?   A . n 
A 1 398 SER 398 417 ?   ?   ?   A . n 
A 1 399 THR 399 418 ?   ?   ?   A . n 
A 1 400 MET 400 419 ?   ?   ?   A . n 
A 1 401 LEU 401 420 ?   ?   ?   A . n 
A 1 402 GLU 402 421 ?   ?   ?   A . n 
A 1 403 ASP 403 422 ?   ?   ?   A . n 
A 1 404 SER 404 423 ?   ?   ?   A . n 
A 1 405 VAL 405 424 ?   ?   ?   A . n 
A 1 406 SER 406 425 ?   ?   ?   A . n 
A 1 407 PRO 407 426 ?   ?   ?   A . n 
A 1 408 LYS 408 427 ?   ?   ?   A . n 
A 1 409 LYS 409 428 ?   ?   ?   A . n 
A 1 410 SER 410 429 ?   ?   ?   A . n 
A 1 411 THR 411 430 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   501  576 HOH HOH A . 
B 2 HOH 2   502  512 HOH HOH A . 
B 2 HOH 3   503  25  HOH HOH A . 
B 2 HOH 4   504  311 HOH HOH A . 
B 2 HOH 5   505  379 HOH HOH A . 
B 2 HOH 6   506  125 HOH HOH A . 
B 2 HOH 7   507  598 HOH HOH A . 
B 2 HOH 8   508  334 HOH HOH A . 
B 2 HOH 9   509  246 HOH HOH A . 
B 2 HOH 10  510  331 HOH HOH A . 
B 2 HOH 11  511  612 HOH HOH A . 
B 2 HOH 12  512  200 HOH HOH A . 
B 2 HOH 13  513  376 HOH HOH A . 
B 2 HOH 14  514  546 HOH HOH A . 
B 2 HOH 15  515  373 HOH HOH A . 
B 2 HOH 16  516  281 HOH HOH A . 
B 2 HOH 17  517  182 HOH HOH A . 
B 2 HOH 18  518  78  HOH HOH A . 
B 2 HOH 19  519  50  HOH HOH A . 
B 2 HOH 20  520  316 HOH HOH A . 
B 2 HOH 21  521  453 HOH HOH A . 
B 2 HOH 22  522  338 HOH HOH A . 
B 2 HOH 23  523  378 HOH HOH A . 
B 2 HOH 24  524  247 HOH HOH A . 
B 2 HOH 25  525  163 HOH HOH A . 
B 2 HOH 26  526  631 HOH HOH A . 
B 2 HOH 27  527  88  HOH HOH A . 
B 2 HOH 28  528  129 HOH HOH A . 
B 2 HOH 29  529  136 HOH HOH A . 
B 2 HOH 30  530  40  HOH HOH A . 
B 2 HOH 31  531  212 HOH HOH A . 
B 2 HOH 32  532  21  HOH HOH A . 
B 2 HOH 33  533  157 HOH HOH A . 
B 2 HOH 34  534  84  HOH HOH A . 
B 2 HOH 35  535  390 HOH HOH A . 
B 2 HOH 36  536  91  HOH HOH A . 
B 2 HOH 37  537  587 HOH HOH A . 
B 2 HOH 38  538  388 HOH HOH A . 
B 2 HOH 39  539  199 HOH HOH A . 
B 2 HOH 40  540  545 HOH HOH A . 
B 2 HOH 41  541  298 HOH HOH A . 
B 2 HOH 42  542  110 HOH HOH A . 
B 2 HOH 43  543  28  HOH HOH A . 
B 2 HOH 44  544  53  HOH HOH A . 
B 2 HOH 45  545  309 HOH HOH A . 
B 2 HOH 46  546  297 HOH HOH A . 
B 2 HOH 47  547  372 HOH HOH A . 
B 2 HOH 48  548  64  HOH HOH A . 
B 2 HOH 49  549  299 HOH HOH A . 
B 2 HOH 50  550  634 HOH HOH A . 
B 2 HOH 51  551  472 HOH HOH A . 
B 2 HOH 52  552  219 HOH HOH A . 
B 2 HOH 53  553  93  HOH HOH A . 
B 2 HOH 54  554  559 HOH HOH A . 
B 2 HOH 55  555  355 HOH HOH A . 
B 2 HOH 56  556  143 HOH HOH A . 
B 2 HOH 57  557  597 HOH HOH A . 
B 2 HOH 58  558  209 HOH HOH A . 
B 2 HOH 59  559  207 HOH HOH A . 
B 2 HOH 60  560  95  HOH HOH A . 
B 2 HOH 61  561  332 HOH HOH A . 
B 2 HOH 62  562  231 HOH HOH A . 
B 2 HOH 63  563  119 HOH HOH A . 
B 2 HOH 64  564  401 HOH HOH A . 
B 2 HOH 65  565  76  HOH HOH A . 
B 2 HOH 66  566  8   HOH HOH A . 
B 2 HOH 67  567  236 HOH HOH A . 
B 2 HOH 68  568  135 HOH HOH A . 
B 2 HOH 69  569  5   HOH HOH A . 
B 2 HOH 70  570  7   HOH HOH A . 
B 2 HOH 71  571  30  HOH HOH A . 
B 2 HOH 72  572  169 HOH HOH A . 
B 2 HOH 73  573  466 HOH HOH A . 
B 2 HOH 74  574  146 HOH HOH A . 
B 2 HOH 75  575  160 HOH HOH A . 
B 2 HOH 76  576  144 HOH HOH A . 
B 2 HOH 77  577  251 HOH HOH A . 
B 2 HOH 78  578  273 HOH HOH A . 
B 2 HOH 79  579  427 HOH HOH A . 
B 2 HOH 80  580  15  HOH HOH A . 
B 2 HOH 81  581  367 HOH HOH A . 
B 2 HOH 82  582  647 HOH HOH A . 
B 2 HOH 83  583  36  HOH HOH A . 
B 2 HOH 84  584  47  HOH HOH A . 
B 2 HOH 85  585  323 HOH HOH A . 
B 2 HOH 86  586  27  HOH HOH A . 
B 2 HOH 87  587  432 HOH HOH A . 
B 2 HOH 88  588  312 HOH HOH A . 
B 2 HOH 89  589  86  HOH HOH A . 
B 2 HOH 90  590  11  HOH HOH A . 
B 2 HOH 91  591  191 HOH HOH A . 
B 2 HOH 92  592  175 HOH HOH A . 
B 2 HOH 93  593  80  HOH HOH A . 
B 2 HOH 94  594  103 HOH HOH A . 
B 2 HOH 95  595  637 HOH HOH A . 
B 2 HOH 96  596  425 HOH HOH A . 
B 2 HOH 97  597  361 HOH HOH A . 
B 2 HOH 98  598  360 HOH HOH A . 
B 2 HOH 99  599  16  HOH HOH A . 
B 2 HOH 100 600  109 HOH HOH A . 
B 2 HOH 101 601  102 HOH HOH A . 
B 2 HOH 102 602  291 HOH HOH A . 
B 2 HOH 103 603  114 HOH HOH A . 
B 2 HOH 104 604  439 HOH HOH A . 
B 2 HOH 105 605  320 HOH HOH A . 
B 2 HOH 106 606  38  HOH HOH A . 
B 2 HOH 107 607  22  HOH HOH A . 
B 2 HOH 108 608  61  HOH HOH A . 
B 2 HOH 109 609  17  HOH HOH A . 
B 2 HOH 110 610  282 HOH HOH A . 
B 2 HOH 111 611  69  HOH HOH A . 
B 2 HOH 112 612  6   HOH HOH A . 
B 2 HOH 113 613  62  HOH HOH A . 
B 2 HOH 114 614  261 HOH HOH A . 
B 2 HOH 115 615  498 HOH HOH A . 
B 2 HOH 116 616  35  HOH HOH A . 
B 2 HOH 117 617  186 HOH HOH A . 
B 2 HOH 118 618  406 HOH HOH A . 
B 2 HOH 119 619  264 HOH HOH A . 
B 2 HOH 120 620  34  HOH HOH A . 
B 2 HOH 121 621  319 HOH HOH A . 
B 2 HOH 122 622  272 HOH HOH A . 
B 2 HOH 123 623  278 HOH HOH A . 
B 2 HOH 124 624  104 HOH HOH A . 
B 2 HOH 125 625  393 HOH HOH A . 
B 2 HOH 126 626  31  HOH HOH A . 
B 2 HOH 127 627  89  HOH HOH A . 
B 2 HOH 128 628  359 HOH HOH A . 
B 2 HOH 129 629  229 HOH HOH A . 
B 2 HOH 130 630  636 HOH HOH A . 
B 2 HOH 131 631  254 HOH HOH A . 
B 2 HOH 132 632  1   HOH HOH A . 
B 2 HOH 133 633  101 HOH HOH A . 
B 2 HOH 134 634  2   HOH HOH A . 
B 2 HOH 135 635  253 HOH HOH A . 
B 2 HOH 136 636  118 HOH HOH A . 
B 2 HOH 137 637  74  HOH HOH A . 
B 2 HOH 138 638  265 HOH HOH A . 
B 2 HOH 139 639  83  HOH HOH A . 
B 2 HOH 140 640  98  HOH HOH A . 
B 2 HOH 141 641  177 HOH HOH A . 
B 2 HOH 142 642  202 HOH HOH A . 
B 2 HOH 143 643  641 HOH HOH A . 
B 2 HOH 144 644  56  HOH HOH A . 
B 2 HOH 145 645  164 HOH HOH A . 
B 2 HOH 146 646  274 HOH HOH A . 
B 2 HOH 147 647  105 HOH HOH A . 
B 2 HOH 148 648  354 HOH HOH A . 
B 2 HOH 149 649  509 HOH HOH A . 
B 2 HOH 150 650  171 HOH HOH A . 
B 2 HOH 151 651  179 HOH HOH A . 
B 2 HOH 152 652  484 HOH HOH A . 
B 2 HOH 153 653  243 HOH HOH A . 
B 2 HOH 154 654  4   HOH HOH A . 
B 2 HOH 155 655  41  HOH HOH A . 
B 2 HOH 156 656  20  HOH HOH A . 
B 2 HOH 157 657  142 HOH HOH A . 
B 2 HOH 158 658  44  HOH HOH A . 
B 2 HOH 159 659  37  HOH HOH A . 
B 2 HOH 160 660  111 HOH HOH A . 
B 2 HOH 161 661  228 HOH HOH A . 
B 2 HOH 162 662  159 HOH HOH A . 
B 2 HOH 163 663  263 HOH HOH A . 
B 2 HOH 164 664  66  HOH HOH A . 
B 2 HOH 165 665  317 HOH HOH A . 
B 2 HOH 166 666  611 HOH HOH A . 
B 2 HOH 167 667  213 HOH HOH A . 
B 2 HOH 168 668  90  HOH HOH A . 
B 2 HOH 169 669  358 HOH HOH A . 
B 2 HOH 170 670  370 HOH HOH A . 
B 2 HOH 171 671  357 HOH HOH A . 
B 2 HOH 172 672  416 HOH HOH A . 
B 2 HOH 173 673  58  HOH HOH A . 
B 2 HOH 174 674  46  HOH HOH A . 
B 2 HOH 175 675  49  HOH HOH A . 
B 2 HOH 176 676  499 HOH HOH A . 
B 2 HOH 177 677  389 HOH HOH A . 
B 2 HOH 178 678  75  HOH HOH A . 
B 2 HOH 179 679  203 HOH HOH A . 
B 2 HOH 180 680  632 HOH HOH A . 
B 2 HOH 181 681  52  HOH HOH A . 
B 2 HOH 182 682  223 HOH HOH A . 
B 2 HOH 183 683  644 HOH HOH A . 
B 2 HOH 184 684  271 HOH HOH A . 
B 2 HOH 185 685  276 HOH HOH A . 
B 2 HOH 186 686  333 HOH HOH A . 
B 2 HOH 187 687  211 HOH HOH A . 
B 2 HOH 188 688  283 HOH HOH A . 
B 2 HOH 189 689  217 HOH HOH A . 
B 2 HOH 190 690  122 HOH HOH A . 
B 2 HOH 191 691  428 HOH HOH A . 
B 2 HOH 192 692  269 HOH HOH A . 
B 2 HOH 193 693  19  HOH HOH A . 
B 2 HOH 194 694  87  HOH HOH A . 
B 2 HOH 195 695  77  HOH HOH A . 
B 2 HOH 196 696  82  HOH HOH A . 
B 2 HOH 197 697  196 HOH HOH A . 
B 2 HOH 198 698  469 HOH HOH A . 
B 2 HOH 199 699  635 HOH HOH A . 
B 2 HOH 200 700  187 HOH HOH A . 
B 2 HOH 201 701  411 HOH HOH A . 
B 2 HOH 202 702  594 HOH HOH A . 
B 2 HOH 203 703  120 HOH HOH A . 
B 2 HOH 204 704  172 HOH HOH A . 
B 2 HOH 205 705  18  HOH HOH A . 
B 2 HOH 206 706  505 HOH HOH A . 
B 2 HOH 207 707  147 HOH HOH A . 
B 2 HOH 208 708  306 HOH HOH A . 
B 2 HOH 209 709  530 HOH HOH A . 
B 2 HOH 210 710  575 HOH HOH A . 
B 2 HOH 211 711  14  HOH HOH A . 
B 2 HOH 212 712  161 HOH HOH A . 
B 2 HOH 213 713  193 HOH HOH A . 
B 2 HOH 214 714  48  HOH HOH A . 
B 2 HOH 215 715  167 HOH HOH A . 
B 2 HOH 216 716  326 HOH HOH A . 
B 2 HOH 217 717  599 HOH HOH A . 
B 2 HOH 218 718  419 HOH HOH A . 
B 2 HOH 219 719  310 HOH HOH A . 
B 2 HOH 220 720  148 HOH HOH A . 
B 2 HOH 221 721  10  HOH HOH A . 
B 2 HOH 222 722  435 HOH HOH A . 
B 2 HOH 223 723  424 HOH HOH A . 
B 2 HOH 224 724  652 HOH HOH A . 
B 2 HOH 225 725  24  HOH HOH A . 
B 2 HOH 226 726  99  HOH HOH A . 
B 2 HOH 227 727  234 HOH HOH A . 
B 2 HOH 228 728  351 HOH HOH A . 
B 2 HOH 229 729  9   HOH HOH A . 
B 2 HOH 230 730  528 HOH HOH A . 
B 2 HOH 231 731  123 HOH HOH A . 
B 2 HOH 232 732  277 HOH HOH A . 
B 2 HOH 233 733  577 HOH HOH A . 
B 2 HOH 234 734  603 HOH HOH A . 
B 2 HOH 235 735  381 HOH HOH A . 
B 2 HOH 236 736  368 HOH HOH A . 
B 2 HOH 237 737  315 HOH HOH A . 
B 2 HOH 238 738  92  HOH HOH A . 
B 2 HOH 239 739  107 HOH HOH A . 
B 2 HOH 240 740  248 HOH HOH A . 
B 2 HOH 241 741  138 HOH HOH A . 
B 2 HOH 242 742  244 HOH HOH A . 
B 2 HOH 243 743  154 HOH HOH A . 
B 2 HOH 244 744  566 HOH HOH A . 
B 2 HOH 245 745  287 HOH HOH A . 
B 2 HOH 246 746  43  HOH HOH A . 
B 2 HOH 247 747  81  HOH HOH A . 
B 2 HOH 248 748  300 HOH HOH A . 
B 2 HOH 249 749  348 HOH HOH A . 
B 2 HOH 250 750  503 HOH HOH A . 
B 2 HOH 251 751  23  HOH HOH A . 
B 2 HOH 252 752  128 HOH HOH A . 
B 2 HOH 253 753  178 HOH HOH A . 
B 2 HOH 254 754  592 HOH HOH A . 
B 2 HOH 255 755  423 HOH HOH A . 
B 2 HOH 256 756  151 HOH HOH A . 
B 2 HOH 257 757  73  HOH HOH A . 
B 2 HOH 258 758  352 HOH HOH A . 
B 2 HOH 259 759  549 HOH HOH A . 
B 2 HOH 260 760  185 HOH HOH A . 
B 2 HOH 261 761  153 HOH HOH A . 
B 2 HOH 262 762  60  HOH HOH A . 
B 2 HOH 263 763  115 HOH HOH A . 
B 2 HOH 264 764  308 HOH HOH A . 
B 2 HOH 265 765  558 HOH HOH A . 
B 2 HOH 266 766  45  HOH HOH A . 
B 2 HOH 267 767  149 HOH HOH A . 
B 2 HOH 268 768  13  HOH HOH A . 
B 2 HOH 269 769  106 HOH HOH A . 
B 2 HOH 270 770  328 HOH HOH A . 
B 2 HOH 271 771  184 HOH HOH A . 
B 2 HOH 272 772  395 HOH HOH A . 
B 2 HOH 273 773  364 HOH HOH A . 
B 2 HOH 274 774  12  HOH HOH A . 
B 2 HOH 275 775  296 HOH HOH A . 
B 2 HOH 276 776  410 HOH HOH A . 
B 2 HOH 277 777  137 HOH HOH A . 
B 2 HOH 278 778  189 HOH HOH A . 
B 2 HOH 279 779  397 HOH HOH A . 
B 2 HOH 280 780  356 HOH HOH A . 
B 2 HOH 281 781  39  HOH HOH A . 
B 2 HOH 282 782  495 HOH HOH A . 
B 2 HOH 283 783  339 HOH HOH A . 
B 2 HOH 284 784  266 HOH HOH A . 
B 2 HOH 285 785  140 HOH HOH A . 
B 2 HOH 286 786  375 HOH HOH A . 
B 2 HOH 287 787  63  HOH HOH A . 
B 2 HOH 288 788  394 HOH HOH A . 
B 2 HOH 289 789  242 HOH HOH A . 
B 2 HOH 290 790  529 HOH HOH A . 
B 2 HOH 291 791  321 HOH HOH A . 
B 2 HOH 292 792  571 HOH HOH A . 
B 2 HOH 293 793  97  HOH HOH A . 
B 2 HOH 294 794  190 HOH HOH A . 
B 2 HOH 295 795  252 HOH HOH A . 
B 2 HOH 296 796  232 HOH HOH A . 
B 2 HOH 297 797  268 HOH HOH A . 
B 2 HOH 298 798  470 HOH HOH A . 
B 2 HOH 299 799  112 HOH HOH A . 
B 2 HOH 300 800  33  HOH HOH A . 
B 2 HOH 301 801  629 HOH HOH A . 
B 2 HOH 302 802  325 HOH HOH A . 
B 2 HOH 303 803  648 HOH HOH A . 
B 2 HOH 304 804  94  HOH HOH A . 
B 2 HOH 305 805  216 HOH HOH A . 
B 2 HOH 306 806  226 HOH HOH A . 
B 2 HOH 307 807  304 HOH HOH A . 
B 2 HOH 308 808  341 HOH HOH A . 
B 2 HOH 309 809  391 HOH HOH A . 
B 2 HOH 310 810  134 HOH HOH A . 
B 2 HOH 311 811  582 HOH HOH A . 
B 2 HOH 312 812  335 HOH HOH A . 
B 2 HOH 313 813  121 HOH HOH A . 
B 2 HOH 314 814  398 HOH HOH A . 
B 2 HOH 315 815  100 HOH HOH A . 
B 2 HOH 316 816  477 HOH HOH A . 
B 2 HOH 317 817  116 HOH HOH A . 
B 2 HOH 318 818  250 HOH HOH A . 
B 2 HOH 319 819  198 HOH HOH A . 
B 2 HOH 320 820  327 HOH HOH A . 
B 2 HOH 321 821  194 HOH HOH A . 
B 2 HOH 322 822  400 HOH HOH A . 
B 2 HOH 323 823  421 HOH HOH A . 
B 2 HOH 324 824  201 HOH HOH A . 
B 2 HOH 325 825  139 HOH HOH A . 
B 2 HOH 326 826  215 HOH HOH A . 
B 2 HOH 327 827  590 HOH HOH A . 
B 2 HOH 328 828  588 HOH HOH A . 
B 2 HOH 329 829  233 HOH HOH A . 
B 2 HOH 330 830  166 HOH HOH A . 
B 2 HOH 331 831  227 HOH HOH A . 
B 2 HOH 332 832  305 HOH HOH A . 
B 2 HOH 333 833  141 HOH HOH A . 
B 2 HOH 334 834  173 HOH HOH A . 
B 2 HOH 335 835  59  HOH HOH A . 
B 2 HOH 336 836  442 HOH HOH A . 
B 2 HOH 337 837  113 HOH HOH A . 
B 2 HOH 338 838  42  HOH HOH A . 
B 2 HOH 339 839  127 HOH HOH A . 
B 2 HOH 340 840  57  HOH HOH A . 
B 2 HOH 341 841  79  HOH HOH A . 
B 2 HOH 342 842  302 HOH HOH A . 
B 2 HOH 343 843  255 HOH HOH A . 
B 2 HOH 344 844  240 HOH HOH A . 
B 2 HOH 345 845  195 HOH HOH A . 
B 2 HOH 346 846  450 HOH HOH A . 
B 2 HOH 347 847  133 HOH HOH A . 
B 2 HOH 348 848  542 HOH HOH A . 
B 2 HOH 349 849  124 HOH HOH A . 
B 2 HOH 350 850  108 HOH HOH A . 
B 2 HOH 351 851  245 HOH HOH A . 
B 2 HOH 352 852  32  HOH HOH A . 
B 2 HOH 353 853  301 HOH HOH A . 
B 2 HOH 354 854  374 HOH HOH A . 
B 2 HOH 355 855  365 HOH HOH A . 
B 2 HOH 356 856  563 HOH HOH A . 
B 2 HOH 357 857  29  HOH HOH A . 
B 2 HOH 358 858  132 HOH HOH A . 
B 2 HOH 359 859  96  HOH HOH A . 
B 2 HOH 360 860  591 HOH HOH A . 
B 2 HOH 361 861  218 HOH HOH A . 
B 2 HOH 362 862  502 HOH HOH A . 
B 2 HOH 363 863  506 HOH HOH A . 
B 2 HOH 364 864  404 HOH HOH A . 
B 2 HOH 365 865  403 HOH HOH A . 
B 2 HOH 366 866  527 HOH HOH A . 
B 2 HOH 367 867  438 HOH HOH A . 
B 2 HOH 368 868  561 HOH HOH A . 
B 2 HOH 369 869  548 HOH HOH A . 
B 2 HOH 370 870  487 HOH HOH A . 
B 2 HOH 371 871  586 HOH HOH A . 
B 2 HOH 372 872  454 HOH HOH A . 
B 2 HOH 373 873  294 HOH HOH A . 
B 2 HOH 374 874  437 HOH HOH A . 
B 2 HOH 375 875  491 HOH HOH A . 
B 2 HOH 376 876  26  HOH HOH A . 
B 2 HOH 377 877  578 HOH HOH A . 
B 2 HOH 378 878  606 HOH HOH A . 
B 2 HOH 379 879  156 HOH HOH A . 
B 2 HOH 380 880  54  HOH HOH A . 
B 2 HOH 381 881  152 HOH HOH A . 
B 2 HOH 382 882  392 HOH HOH A . 
B 2 HOH 383 883  543 HOH HOH A . 
B 2 HOH 384 884  628 HOH HOH A . 
B 2 HOH 385 885  3   HOH HOH A . 
B 2 HOH 386 886  436 HOH HOH A . 
B 2 HOH 387 887  595 HOH HOH A . 
B 2 HOH 388 888  344 HOH HOH A . 
B 2 HOH 389 889  383 HOH HOH A . 
B 2 HOH 390 890  145 HOH HOH A . 
B 2 HOH 391 891  386 HOH HOH A . 
B 2 HOH 392 892  593 HOH HOH A . 
B 2 HOH 393 893  443 HOH HOH A . 
B 2 HOH 394 894  630 HOH HOH A . 
B 2 HOH 395 895  521 HOH HOH A . 
B 2 HOH 396 896  303 HOH HOH A . 
B 2 HOH 397 897  155 HOH HOH A . 
B 2 HOH 398 898  286 HOH HOH A . 
B 2 HOH 399 899  72  HOH HOH A . 
B 2 HOH 400 900  353 HOH HOH A . 
B 2 HOH 401 901  537 HOH HOH A . 
B 2 HOH 402 902  653 HOH HOH A . 
B 2 HOH 403 903  474 HOH HOH A . 
B 2 HOH 404 904  462 HOH HOH A . 
B 2 HOH 405 905  369 HOH HOH A . 
B 2 HOH 406 906  624 HOH HOH A . 
B 2 HOH 407 907  385 HOH HOH A . 
B 2 HOH 408 908  560 HOH HOH A . 
B 2 HOH 409 909  581 HOH HOH A . 
B 2 HOH 410 910  468 HOH HOH A . 
B 2 HOH 411 911  162 HOH HOH A . 
B 2 HOH 412 912  431 HOH HOH A . 
B 2 HOH 413 913  626 HOH HOH A . 
B 2 HOH 414 914  646 HOH HOH A . 
B 2 HOH 415 915  465 HOH HOH A . 
B 2 HOH 416 916  405 HOH HOH A . 
B 2 HOH 417 917  284 HOH HOH A . 
B 2 HOH 418 918  622 HOH HOH A . 
B 2 HOH 419 919  371 HOH HOH A . 
B 2 HOH 420 920  290 HOH HOH A . 
B 2 HOH 421 921  539 HOH HOH A . 
B 2 HOH 422 922  448 HOH HOH A . 
B 2 HOH 423 923  510 HOH HOH A . 
B 2 HOH 424 924  547 HOH HOH A . 
B 2 HOH 425 925  516 HOH HOH A . 
B 2 HOH 426 926  440 HOH HOH A . 
B 2 HOH 427 927  449 HOH HOH A . 
B 2 HOH 428 928  415 HOH HOH A . 
B 2 HOH 429 929  621 HOH HOH A . 
B 2 HOH 430 930  343 HOH HOH A . 
B 2 HOH 431 931  651 HOH HOH A . 
B 2 HOH 432 932  387 HOH HOH A . 
B 2 HOH 433 933  181 HOH HOH A . 
B 2 HOH 434 934  655 HOH HOH A . 
B 2 HOH 435 935  413 HOH HOH A . 
B 2 HOH 436 936  206 HOH HOH A . 
B 2 HOH 437 937  235 HOH HOH A . 
B 2 HOH 438 938  656 HOH HOH A . 
B 2 HOH 439 939  619 HOH HOH A . 
B 2 HOH 440 940  526 HOH HOH A . 
B 2 HOH 441 941  494 HOH HOH A . 
B 2 HOH 442 942  557 HOH HOH A . 
B 2 HOH 443 943  600 HOH HOH A . 
B 2 HOH 444 944  579 HOH HOH A . 
B 2 HOH 445 945  336 HOH HOH A . 
B 2 HOH 446 946  478 HOH HOH A . 
B 2 HOH 447 947  501 HOH HOH A . 
B 2 HOH 448 948  471 HOH HOH A . 
B 2 HOH 449 949  259 HOH HOH A . 
B 2 HOH 450 950  249 HOH HOH A . 
B 2 HOH 451 951  267 HOH HOH A . 
B 2 HOH 452 952  430 HOH HOH A . 
B 2 HOH 453 953  444 HOH HOH A . 
B 2 HOH 454 954  623 HOH HOH A . 
B 2 HOH 455 955  117 HOH HOH A . 
B 2 HOH 456 956  609 HOH HOH A . 
B 2 HOH 457 957  295 HOH HOH A . 
B 2 HOH 458 958  583 HOH HOH A . 
B 2 HOH 459 959  596 HOH HOH A . 
B 2 HOH 460 960  402 HOH HOH A . 
B 2 HOH 461 961  285 HOH HOH A . 
B 2 HOH 462 962  519 HOH HOH A . 
B 2 HOH 463 963  580 HOH HOH A . 
B 2 HOH 464 964  564 HOH HOH A . 
B 2 HOH 465 965  589 HOH HOH A . 
B 2 HOH 466 966  433 HOH HOH A . 
B 2 HOH 467 967  399 HOH HOH A . 
B 2 HOH 468 968  158 HOH HOH A . 
B 2 HOH 469 969  554 HOH HOH A . 
B 2 HOH 470 970  486 HOH HOH A . 
B 2 HOH 471 971  572 HOH HOH A . 
B 2 HOH 472 972  313 HOH HOH A . 
B 2 HOH 473 973  540 HOH HOH A . 
B 2 HOH 474 974  567 HOH HOH A . 
B 2 HOH 475 975  293 HOH HOH A . 
B 2 HOH 476 976  258 HOH HOH A . 
B 2 HOH 477 977  363 HOH HOH A . 
B 2 HOH 478 978  174 HOH HOH A . 
B 2 HOH 479 979  65  HOH HOH A . 
B 2 HOH 480 980  455 HOH HOH A . 
B 2 HOH 481 981  532 HOH HOH A . 
B 2 HOH 482 982  514 HOH HOH A . 
B 2 HOH 483 983  238 HOH HOH A . 
B 2 HOH 484 984  345 HOH HOH A . 
B 2 HOH 485 985  329 HOH HOH A . 
B 2 HOH 486 986  170 HOH HOH A . 
B 2 HOH 487 987  257 HOH HOH A . 
B 2 HOH 488 988  515 HOH HOH A . 
B 2 HOH 489 989  67  HOH HOH A . 
B 2 HOH 490 990  569 HOH HOH A . 
B 2 HOH 491 991  513 HOH HOH A . 
B 2 HOH 492 992  210 HOH HOH A . 
B 2 HOH 493 993  292 HOH HOH A . 
B 2 HOH 494 994  615 HOH HOH A . 
B 2 HOH 495 995  483 HOH HOH A . 
B 2 HOH 496 996  280 HOH HOH A . 
B 2 HOH 497 997  658 HOH HOH A . 
B 2 HOH 498 998  347 HOH HOH A . 
B 2 HOH 499 999  485 HOH HOH A . 
B 2 HOH 500 1000 459 HOH HOH A . 
B 2 HOH 501 1001 645 HOH HOH A . 
B 2 HOH 502 1002 279 HOH HOH A . 
B 2 HOH 503 1003 221 HOH HOH A . 
B 2 HOH 504 1004 544 HOH HOH A . 
B 2 HOH 505 1005 463 HOH HOH A . 
B 2 HOH 506 1006 70  HOH HOH A . 
B 2 HOH 507 1007 617 HOH HOH A . 
B 2 HOH 508 1008 346 HOH HOH A . 
B 2 HOH 509 1009 490 HOH HOH A . 
B 2 HOH 510 1010 55  HOH HOH A . 
B 2 HOH 511 1011 176 HOH HOH A . 
B 2 HOH 512 1012 496 HOH HOH A . 
B 2 HOH 513 1013 126 HOH HOH A . 
B 2 HOH 514 1014 441 HOH HOH A . 
B 2 HOH 515 1015 262 HOH HOH A . 
B 2 HOH 516 1016 445 HOH HOH A . 
B 2 HOH 517 1017 188 HOH HOH A . 
B 2 HOH 518 1018 446 HOH HOH A . 
B 2 HOH 519 1019 447 HOH HOH A . 
B 2 HOH 520 1020 362 HOH HOH A . 
B 2 HOH 521 1021 192 HOH HOH A . 
B 2 HOH 522 1022 165 HOH HOH A . 
B 2 HOH 523 1023 541 HOH HOH A . 
B 2 HOH 524 1024 642 HOH HOH A . 
B 2 HOH 525 1025 585 HOH HOH A . 
B 2 HOH 526 1026 342 HOH HOH A . 
B 2 HOH 527 1027 130 HOH HOH A . 
B 2 HOH 528 1028 605 HOH HOH A . 
B 2 HOH 529 1029 275 HOH HOH A . 
B 2 HOH 530 1030 384 HOH HOH A . 
B 2 HOH 531 1031 550 HOH HOH A . 
B 2 HOH 532 1032 488 HOH HOH A . 
B 2 HOH 533 1033 451 HOH HOH A . 
B 2 HOH 534 1034 654 HOH HOH A . 
B 2 HOH 535 1035 507 HOH HOH A . 
B 2 HOH 536 1036 205 HOH HOH A . 
B 2 HOH 537 1037 556 HOH HOH A . 
B 2 HOH 538 1038 426 HOH HOH A . 
B 2 HOH 539 1039 256 HOH HOH A . 
B 2 HOH 540 1040 639 HOH HOH A . 
B 2 HOH 541 1041 553 HOH HOH A . 
B 2 HOH 542 1042 616 HOH HOH A . 
B 2 HOH 543 1043 620 HOH HOH A . 
B 2 HOH 544 1044 538 HOH HOH A . 
B 2 HOH 545 1045 239 HOH HOH A . 
B 2 HOH 546 1046 608 HOH HOH A . 
B 2 HOH 547 1047 627 HOH HOH A . 
B 2 HOH 548 1048 224 HOH HOH A . 
B 2 HOH 549 1049 340 HOH HOH A . 
B 2 HOH 550 1050 479 HOH HOH A . 
B 2 HOH 551 1051 467 HOH HOH A . 
B 2 HOH 552 1052 481 HOH HOH A . 
B 2 HOH 553 1053 625 HOH HOH A . 
B 2 HOH 554 1054 604 HOH HOH A . 
B 2 HOH 555 1055 420 HOH HOH A . 
B 2 HOH 556 1056 508 HOH HOH A . 
B 2 HOH 557 1057 464 HOH HOH A . 
B 2 HOH 558 1058 377 HOH HOH A . 
B 2 HOH 559 1059 584 HOH HOH A . 
B 2 HOH 560 1060 396 HOH HOH A . 
B 2 HOH 561 1061 520 HOH HOH A . 
B 2 HOH 562 1062 643 HOH HOH A . 
B 2 HOH 563 1063 408 HOH HOH A . 
B 2 HOH 564 1064 480 HOH HOH A . 
B 2 HOH 565 1065 607 HOH HOH A . 
B 2 HOH 566 1066 288 HOH HOH A . 
B 2 HOH 567 1067 307 HOH HOH A . 
B 2 HOH 568 1068 476 HOH HOH A . 
B 2 HOH 569 1069 492 HOH HOH A . 
B 2 HOH 570 1070 452 HOH HOH A . 
B 2 HOH 571 1071 511 HOH HOH A . 
B 2 HOH 572 1072 85  HOH HOH A . 
B 2 HOH 573 1073 504 HOH HOH A . 
B 2 HOH 574 1074 222 HOH HOH A . 
B 2 HOH 575 1075 473 HOH HOH A . 
B 2 HOH 576 1076 71  HOH HOH A . 
B 2 HOH 577 1077 349 HOH HOH A . 
B 2 HOH 578 1078 330 HOH HOH A . 
B 2 HOH 579 1079 555 HOH HOH A . 
B 2 HOH 580 1080 434 HOH HOH A . 
B 2 HOH 581 1081 493 HOH HOH A . 
B 2 HOH 582 1082 518 HOH HOH A . 
B 2 HOH 583 1083 241 HOH HOH A . 
B 2 HOH 584 1084 457 HOH HOH A . 
B 2 HOH 585 1085 422 HOH HOH A . 
B 2 HOH 586 1086 208 HOH HOH A . 
B 2 HOH 587 1087 183 HOH HOH A . 
B 2 HOH 588 1088 497 HOH HOH A . 
B 2 HOH 589 1089 552 HOH HOH A . 
B 2 HOH 590 1090 225 HOH HOH A . 
B 2 HOH 591 1091 500 HOH HOH A . 
B 2 HOH 592 1092 230 HOH HOH A . 
B 2 HOH 593 1093 314 HOH HOH A . 
B 2 HOH 594 1094 657 HOH HOH A . 
B 2 HOH 595 1095 458 HOH HOH A . 
B 2 HOH 596 1096 414 HOH HOH A . 
B 2 HOH 597 1097 412 HOH HOH A . 
B 2 HOH 598 1098 337 HOH HOH A . 
B 2 HOH 599 1099 551 HOH HOH A . 
B 2 HOH 600 1100 380 HOH HOH A . 
B 2 HOH 601 1101 350 HOH HOH A . 
B 2 HOH 602 1102 68  HOH HOH A . 
B 2 HOH 603 1103 574 HOH HOH A . 
B 2 HOH 604 1104 650 HOH HOH A . 
B 2 HOH 605 1105 324 HOH HOH A . 
B 2 HOH 606 1106 610 HOH HOH A . 
B 2 HOH 607 1107 322 HOH HOH A . 
B 2 HOH 608 1108 409 HOH HOH A . 
B 2 HOH 609 1109 536 HOH HOH A . 
B 2 HOH 610 1110 214 HOH HOH A . 
B 2 HOH 611 1111 570 HOH HOH A . 
B 2 HOH 612 1112 523 HOH HOH A . 
B 2 HOH 613 1113 407 HOH HOH A . 
B 2 HOH 614 1114 534 HOH HOH A . 
B 2 HOH 615 1115 220 HOH HOH A . 
B 2 HOH 616 1116 489 HOH HOH A . 
B 2 HOH 617 1117 318 HOH HOH A . 
B 2 HOH 618 1118 418 HOH HOH A . 
B 2 HOH 619 1119 456 HOH HOH A . 
B 2 HOH 620 1120 260 HOH HOH A . 
B 2 HOH 621 1121 614 HOH HOH A . 
B 2 HOH 622 1122 633 HOH HOH A . 
B 2 HOH 623 1123 602 HOH HOH A . 
B 2 HOH 624 1124 533 HOH HOH A . 
B 2 HOH 625 1125 51  HOH HOH A . 
B 2 HOH 626 1126 517 HOH HOH A . 
B 2 HOH 627 1127 150 HOH HOH A . 
B 2 HOH 628 1128 180 HOH HOH A . 
B 2 HOH 629 1129 525 HOH HOH A . 
B 2 HOH 630 1130 535 HOH HOH A . 
B 2 HOH 631 1131 601 HOH HOH A . 
B 2 HOH 632 1132 168 HOH HOH A . 
B 2 HOH 633 1133 382 HOH HOH A . 
B 2 HOH 634 1134 461 HOH HOH A . 
B 2 HOH 635 1135 429 HOH HOH A . 
B 2 HOH 636 1136 197 HOH HOH A . 
B 2 HOH 637 1137 475 HOH HOH A . 
B 2 HOH 638 1138 237 HOH HOH A . 
B 2 HOH 639 1139 638 HOH HOH A . 
B 2 HOH 640 1140 573 HOH HOH A . 
B 2 HOH 641 1141 366 HOH HOH A . 
B 2 HOH 642 1142 640 HOH HOH A . 
B 2 HOH 643 1143 131 HOH HOH A . 
B 2 HOH 644 1144 417 HOH HOH A . 
B 2 HOH 645 1145 562 HOH HOH A . 
B 2 HOH 646 1146 524 HOH HOH A . 
B 2 HOH 647 1147 568 HOH HOH A . 
B 2 HOH 648 1148 618 HOH HOH A . 
B 2 HOH 649 1149 204 HOH HOH A . 
B 2 HOH 650 1150 289 HOH HOH A . 
B 2 HOH 651 1151 460 HOH HOH A . 
B 2 HOH 652 1152 531 HOH HOH A . 
B 2 HOH 653 1153 270 HOH HOH A . 
B 2 HOH 654 1154 565 HOH HOH A . 
B 2 HOH 655 1155 522 HOH HOH A . 
B 2 HOH 656 1156 613 HOH HOH A . 
B 2 HOH 657 1157 649 HOH HOH A . 
B 2 HOH 658 1158 482 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASN 12  ? CG  ? A ASN 23  CG  
2  1 Y 1 A ASN 12  ? OD1 ? A ASN 23  OD1 
3  1 Y 1 A ASN 12  ? ND2 ? A ASN 23  ND2 
4  1 Y 0 A ARG 35  ? CD  ? A ARG 46  CD  
5  1 Y 0 A ARG 35  ? NE  ? A ARG 46  NE  
6  1 Y 0 A ARG 35  ? CZ  ? A ARG 46  CZ  
7  1 Y 0 A ARG 35  ? NH1 ? A ARG 46  NH1 
8  1 Y 0 A ARG 35  ? NH2 ? A ARG 46  NH2 
9  1 Y 0 A ARG 74  ? CD  ? A ARG 85  CD  
10 1 Y 0 A ARG 74  ? NE  ? A ARG 85  NE  
11 1 Y 0 A ARG 74  ? CZ  ? A ARG 85  CZ  
12 1 Y 0 A ARG 74  ? NH1 ? A ARG 85  NH1 
13 1 Y 0 A ARG 74  ? NH2 ? A ARG 85  NH2 
14 1 Y 1 A ARG 82  ? CG  ? A ARG 93  CG  
15 1 Y 1 A ARG 82  ? CD  ? A ARG 93  CD  
16 1 Y 1 A ARG 82  ? NE  ? A ARG 93  NE  
17 1 Y 1 A ARG 82  ? CZ  ? A ARG 93  CZ  
18 1 Y 1 A ARG 82  ? NH1 ? A ARG 93  NH1 
19 1 Y 1 A ARG 82  ? NH2 ? A ARG 93  NH2 
20 1 Y 1 A MET 134 ? CG  ? A MET 145 CG  
21 1 Y 1 A MET 134 ? SD  ? A MET 145 SD  
22 1 Y 1 A MET 134 ? CE  ? A MET 145 CE  
23 1 Y 1 A ASP 169 ? CG  ? A ASP 150 CG  
24 1 Y 1 A ASP 169 ? OD1 ? A ASP 150 OD1 
25 1 Y 1 A ASP 169 ? OD2 ? A ASP 150 OD2 
26 1 Y 1 A ARG 207 ? CG  ? A ARG 188 CG  
27 1 Y 1 A ARG 207 ? CD  ? A ARG 188 CD  
28 1 Y 1 A ARG 207 ? NE  ? A ARG 188 NE  
29 1 Y 1 A ARG 207 ? CZ  ? A ARG 188 CZ  
30 1 Y 1 A ARG 207 ? NH1 ? A ARG 188 NH1 
31 1 Y 1 A ARG 207 ? NH2 ? A ARG 188 NH2 
32 1 Y 0 A LYS 268 ? CG  ? A LYS 249 CG  
33 1 Y 0 A LYS 268 ? CD  ? A LYS 249 CD  
34 1 Y 0 A LYS 268 ? CE  ? A LYS 249 CE  
35 1 Y 0 A LYS 268 ? NZ  ? A LYS 249 NZ  
36 1 Y 0 A ARG 277 ? CG  ? A ARG 258 CG  
37 1 Y 0 A ARG 277 ? CD  ? A ARG 258 CD  
38 1 Y 0 A ARG 277 ? NE  ? A ARG 258 NE  
39 1 Y 0 A ARG 277 ? CZ  ? A ARG 258 CZ  
40 1 Y 0 A ARG 277 ? NH1 ? A ARG 258 NH1 
41 1 Y 0 A ARG 277 ? NH2 ? A ARG 258 NH2 
42 1 Y 1 A LYS 320 ? CG  ? A LYS 301 CG  
43 1 Y 1 A LYS 320 ? CD  ? A LYS 301 CD  
44 1 Y 1 A LYS 320 ? CE  ? A LYS 301 CE  
45 1 Y 1 A LYS 320 ? NZ  ? A LYS 301 NZ  
46 1 Y 1 A LYS 322 ? CG  ? A LYS 303 CG  
47 1 Y 1 A LYS 322 ? CD  ? A LYS 303 CD  
48 1 Y 1 A LYS 322 ? CE  ? A LYS 303 CE  
49 1 Y 1 A LYS 322 ? NZ  ? A LYS 303 NZ  
50 1 Y 0 A LYS 324 ? CG  ? A LYS 305 CG  
51 1 Y 0 A LYS 324 ? CD  ? A LYS 305 CD  
52 1 Y 0 A LYS 324 ? CE  ? A LYS 305 CE  
53 1 Y 0 A LYS 324 ? NZ  ? A LYS 305 NZ  
54 1 Y 1 A LYS 334 ? CG  ? A LYS 315 CG  
55 1 Y 1 A LYS 334 ? CD  ? A LYS 315 CD  
56 1 Y 1 A LYS 334 ? CE  ? A LYS 315 CE  
57 1 Y 1 A LYS 334 ? NZ  ? A LYS 315 NZ  
58 1 Y 1 A ASP 375 ? CG  ? A ASP 356 CG  
59 1 Y 1 A ASP 375 ? OD1 ? A ASP 356 OD1 
60 1 Y 1 A ASP 375 ? OD2 ? A ASP 356 OD2 
61 1 Y 1 A ARG 397 ? CG  ? A ARG 378 CG  
62 1 Y 1 A ARG 397 ? CD  ? A ARG 378 CD  
63 1 Y 1 A ARG 397 ? NE  ? A ARG 378 NE  
64 1 Y 1 A ARG 397 ? CZ  ? A ARG 378 CZ  
65 1 Y 1 A ARG 397 ? NH1 ? A ARG 378 NH1 
66 1 Y 1 A ARG 397 ? NH2 ? A ARG 378 NH2 
67 1 Y 1 A LYS 404 ? CG  ? A LYS 385 CG  
68 1 Y 1 A LYS 404 ? CD  ? A LYS 385 CD  
69 1 Y 1 A LYS 404 ? CE  ? A LYS 385 CE  
70 1 Y 1 A LYS 404 ? NZ  ? A LYS 385 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS       ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? pointless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DZ5 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     110.399 
_cell.length_a_esd                 ? 
_cell.length_b                     66.886 
_cell.length_b_esd                 ? 
_cell.length_c                     68.226 
_cell.length_c_esd                 ? 
_cell.volume                       503790.848 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DZ5 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DZ5 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.65 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          53.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG4000 16%, NaCl 0.1M, DTT 2mM' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            300 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97934 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97934 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          19.21 
_reflns.entry_id                                       9DZ5 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.74 
_reflns.d_resolution_low                               34.11 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     52268 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.22 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.74 
_reflns_shell.d_res_low                                     1.77 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2583 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.329 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.05 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DZ5 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.74 
_refine.ls_d_res_low                             34.11 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     51999 
_refine.ls_number_reflns_R_free                  2528 
_refine.ls_number_reflns_R_work                  49471 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.11 
_refine.ls_percent_reflns_R_free                 4.86 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1994 
_refine.ls_R_factor_R_free                       0.2242 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1981 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.1592 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2040 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.74 
_refine_hist.d_res_low                        34.11 
_refine_hist.number_atoms_solvent             658 
_refine_hist.number_atoms_total               3685 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3027 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0074 ? 3130 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9949 ? 4223 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0646 ? 462  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0109 ? 544  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.4126 ? 424  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.74 1.77  . . 123 2588 94.59  . . . . 0.3264 . . . . . . . . . . . 0.3692 
'X-RAY DIFFRACTION' 1.77 1.81  . . 134 2718 98.14  . . . . 0.2987 . . . . . . . . . . . 0.3735 
'X-RAY DIFFRACTION' 1.81 1.85  . . 149 2677 98.71  . . . . 0.2776 . . . . . . . . . . . 0.2874 
'X-RAY DIFFRACTION' 1.85 1.89  . . 180 2665 99.34  . . . . 0.2632 . . . . . . . . . . . 0.2886 
'X-RAY DIFFRACTION' 1.89 1.94  . . 140 2723 99.65  . . . . 0.2518 . . . . . . . . . . . 0.2856 
'X-RAY DIFFRACTION' 1.94 1.99  . . 164 2703 99.58  . . . . 0.2487 . . . . . . . . . . . 0.2904 
'X-RAY DIFFRACTION' 1.99 2.05  . . 132 2698 98.26  . . . . 0.2222 . . . . . . . . . . . 0.2598 
'X-RAY DIFFRACTION' 2.05 2.12  . . 107 2732 97.86  . . . . 0.1974 . . . . . . . . . . . 0.1809 
'X-RAY DIFFRACTION' 2.12 2.19  . . 139 2733 100.00 . . . . 0.1942 . . . . . . . . . . . 0.2302 
'X-RAY DIFFRACTION' 2.19 2.28  . . 132 2774 99.86  . . . . 0.1986 . . . . . . . . . . . 0.2543 
'X-RAY DIFFRACTION' 2.28 2.39  . . 150 2738 99.90  . . . . 0.1992 . . . . . . . . . . . 0.2320 
'X-RAY DIFFRACTION' 2.39 2.51  . . 140 2771 99.86  . . . . 0.1976 . . . . . . . . . . . 0.2250 
'X-RAY DIFFRACTION' 2.51 2.67  . . 130 2766 99.90  . . . . 0.2003 . . . . . . . . . . . 0.2176 
'X-RAY DIFFRACTION' 2.67 2.87  . . 135 2789 99.83  . . . . 0.2000 . . . . . . . . . . . 0.2374 
'X-RAY DIFFRACTION' 2.87 3.16  . . 152 2778 99.59  . . . . 0.1922 . . . . . . . . . . . 0.2222 
'X-RAY DIFFRACTION' 3.16 3.62  . . 138 2801 99.86  . . . . 0.1728 . . . . . . . . . . . 0.2104 
'X-RAY DIFFRACTION' 3.62 4.56  . . 149 2833 99.50  . . . . 0.1542 . . . . . . . . . . . 0.1571 
'X-RAY DIFFRACTION' 4.56 34.11 . . 134 2984 99.52  . . . . 0.1830 . . . . . . . . . . . 0.2014 
# 
_struct.entry_id                     9DZ5 
_struct.title                        
'Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a D397R mutation' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DZ5 
_struct_keywords.text            'integrin, beta-2, talin, FERM, complex, CELL ADHESION' 
_struct_keywords.pdbx_keywords   'CELL ADHESION' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    TLN1_MOUSE 
_struct_ref.pdbx_db_accession          P26039 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTME
YRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEK
LKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG
FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMK
GKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIIL
KKKKSKDHFGLEGDEESTMLEDSVSPKKST
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9DZ5 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 12 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 411 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P26039 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  430 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       430 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DZ5 MET A 1   ? UNP P26039 ?   ?   'initiating methionine' -10 1  
1 9DZ5 ASN A 2   ? UNP P26039 ?   ?   'expression tag'        -9  2  
1 9DZ5 ASN A 3   ? UNP P26039 ?   ?   'expression tag'        -8  3  
1 9DZ5 ASP A 4   ? UNP P26039 ?   ?   'expression tag'        -7  4  
1 9DZ5 ASN A 5   ? UNP P26039 ?   ?   'expression tag'        -6  5  
1 9DZ5 PRO A 6   ? UNP P26039 ?   ?   'expression tag'        -5  6  
1 9DZ5 LEU A 7   ? UNP P26039 ?   ?   'expression tag'        -4  7  
1 9DZ5 PHE A 8   ? UNP P26039 ?   ?   'expression tag'        -3  8  
1 9DZ5 LYS A 9   ? UNP P26039 ?   ?   'expression tag'        -2  9  
1 9DZ5 SER A 10  ? UNP P26039 ?   ?   'expression tag'        -1  10 
1 9DZ5 ALA A 11  ? UNP P26039 ?   ?   'expression tag'        0   11 
1 9DZ5 ?   A ?   ? UNP P26039 GLY 141 deletion                ?   12 
1 9DZ5 ?   A ?   ? UNP P26039 THR 142 deletion                ?   13 
1 9DZ5 ?   A ?   ? UNP P26039 GLY 143 deletion                ?   14 
1 9DZ5 ?   A ?   ? UNP P26039 THR 144 deletion                ?   15 
1 9DZ5 ?   A ?   ? UNP P26039 LEU 145 deletion                ?   16 
1 9DZ5 ?   A ?   ? UNP P26039 ARG 146 deletion                ?   17 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 147 deletion                ?   18 
1 9DZ5 ?   A ?   ? UNP P26039 ASP 148 deletion                ?   19 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 149 deletion                ?   20 
1 9DZ5 ?   A ?   ? UNP P26039 THR 150 deletion                ?   21 
1 9DZ5 ?   A ?   ? UNP P26039 LEU 151 deletion                ?   22 
1 9DZ5 ?   A ?   ? UNP P26039 LEU 152 deletion                ?   23 
1 9DZ5 ?   A ?   ? UNP P26039 ARG 153 deletion                ?   24 
1 9DZ5 ?   A ?   ? UNP P26039 ASP 154 deletion                ?   25 
1 9DZ5 ?   A ?   ? UNP P26039 GLU 155 deletion                ?   26 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 156 deletion                ?   27 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 157 deletion                ?   28 
1 9DZ5 ?   A ?   ? UNP P26039 MET 158 deletion                ?   29 
1 9DZ5 ?   A ?   ? UNP P26039 GLU 159 deletion                ?   30 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 160 deletion                ?   31 
1 9DZ5 ?   A ?   ? UNP P26039 LEU 161 deletion                ?   32 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 162 deletion                ?   33 
1 9DZ5 ?   A ?   ? UNP P26039 GLN 163 deletion                ?   34 
1 9DZ5 ?   A ?   ? UNP P26039 LYS 164 deletion                ?   35 
1 9DZ5 ?   A ?   ? UNP P26039 LEU 165 deletion                ?   36 
1 9DZ5 ?   A ?   ? UNP P26039 HIS 166 deletion                ?   37 
1 9DZ5 ?   A ?   ? UNP P26039 THR 167 deletion                ?   38 
1 9DZ5 ?   A ?   ? UNP P26039 ASP 168 deletion                ?   39 
1 9DZ5 ?   A ?   ? UNP P26039 ASP 169 deletion                ?   40 
1 9DZ5 ?   A ?   ? UNP P26039 GLU 170 deletion                ?   41 
1 9DZ5 ARG A 378 ? UNP P26039 ASP 397 'engineered mutation'   397 42 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'assay for oligomerization' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 MET A 35  ? ILE A 47  ? MET A 24  ILE A 36  1 ? 13 
HELX_P HELX_P2  AA2 PRO A 48  ? ALA A 52  ? PRO A 37  ALA A 41  5 ? 5  
HELX_P HELX_P3  AA3 PRO A 54  ? ASN A 56  ? PRO A 43  ASN A 45  5 ? 3  
HELX_P HELX_P4  AA4 ASP A 66  ? GLY A 70  ? ASP A 55  GLY A 59  5 ? 5  
HELX_P HELX_P5  AA5 ALA A 78  ? MET A 83  ? ALA A 67  MET A 72  5 ? 6  
HELX_P HELX_P6  AA6 THR A 118 ? ILE A 130 ? THR A 107 ILE A 119 1 ? 13 
HELX_P HELX_P7  AA7 ASN A 134 ? ASP A 136 ? ASN A 123 ASP A 125 5 ? 3  
HELX_P HELX_P8  AA8 ASP A 150 ? TRP A 154 ? ASP A 169 TRP A 173 5 ? 5  
HELX_P HELX_P9  AA9 LEU A 161 ? GLY A 165 ? LEU A 180 GLY A 184 5 ? 5  
HELX_P HELX_P10 AB1 PHE A 179 ? GLN A 183 ? PHE A 198 GLN A 202 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 189 ? ASN A 206 ? ASP A 208 ASN A 225 1 ? 18 
HELX_P HELX_P12 AB3 SER A 212 ? GLY A 229 ? SER A 231 GLY A 248 1 ? 18 
HELX_P HELX_P13 AB4 ASP A 242 ? PHE A 246 ? ASP A 261 PHE A 265 5 ? 5  
HELX_P HELX_P14 AB5 PRO A 248 ? VAL A 252 ? PRO A 267 VAL A 271 5 ? 5  
HELX_P HELX_P15 AB6 LYS A 253 ? GLN A 254 ? LYS A 272 GLN A 273 5 ? 2  
HELX_P HELX_P16 AB7 LYS A 255 ? CYS A 267 ? LYS A 274 CYS A 286 1 ? 13 
HELX_P HELX_P17 AB8 SER A 271 ? SER A 285 ? SER A 290 SER A 304 1 ? 15 
HELX_P HELX_P18 AB9 THR A 335 ? ILE A 337 ? THR A 354 ILE A 356 5 ? 3  
HELX_P HELX_P19 AC1 PHE A 351 ? GLN A 355 ? PHE A 370 GLN A 374 5 ? 5  
HELX_P HELX_P20 AC2 GLU A 365 ? LYS A 385 ? GLU A 384 LYS A 404 1 ? 21 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 24  ? PHE A 30  ? VAL A 13  PHE A 19  
AA1 2 LEU A 15  ? ILE A 21  ? LEU A 4   ILE A 10  
AA1 3 THR A 89  ? LYS A 94  ? THR A 78  LYS A 83  
AA1 4 PHE A 58  ? LEU A 62  ? PHE A 47  LEU A 51  
AA1 5 ILE A 71  ? TRP A 72  ? ILE A 60  TRP A 61  
AA2 1 VAL A 108 ? ASP A 114 ? VAL A 97  ASP A 103 
AA2 2 GLN A 96  ? ARG A 102 ? GLN A 85  ARG A 91  
AA2 3 LEU A 172 ? ARG A 176 ? LEU A 191 ARG A 195 
AA2 4 TYR A 138 ? VAL A 141 ? TYR A 127 VAL A 130 
AA3 1 SER A 292 ? GLU A 298 ? SER A 311 GLU A 317 
AA3 2 VAL A 307 ? ILE A 313 ? VAL A 326 ILE A 332 
AA3 3 CYS A 317 ? VAL A 321 ? CYS A 336 VAL A 340 
AA3 4 VAL A 328 ? SER A 333 ? VAL A 347 SER A 352 
AA4 1 ARG A 339 ? ALA A 342 ? ARG A 358 ALA A 361 
AA4 2 SER A 346 ? ASP A 350 ? SER A 365 ASP A 369 
AA4 3 TYR A 359 ? GLN A 362 ? TYR A 378 GLN A 381 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LYS A 26  ? O LYS A 15  N ILE A 19  ? N ILE A 8   
AA1 2 3 N LYS A 18  ? N LYS A 7   O MET A 90  ? O MET A 79  
AA1 3 4 O GLU A 91  ? O GLU A 80  N PHE A 61  ? N PHE A 50  
AA1 4 5 N LEU A 62  ? N LEU A 51  O ILE A 71  ? O ILE A 60  
AA2 1 2 O LYS A 109 ? O LYS A 98  N ILE A 101 ? N ILE A 90  
AA2 2 3 N ARG A 102 ? N ARG A 91  O LEU A 172 ? O LEU A 191 
AA2 3 4 O LEU A 173 ? O LEU A 192 N VAL A 141 ? N VAL A 130 
AA3 1 2 N GLU A 298 ? N GLU A 317 O VAL A 307 ? O VAL A 326 
AA3 2 3 N LEU A 310 ? N LEU A 329 O VAL A 321 ? O VAL A 340 
AA3 3 4 N VAL A 318 ? N VAL A 337 O TRP A 332 ? O TRP A 351 
AA4 1 2 N ARG A 339 ? N ARG A 358 O ASP A 350 ? O ASP A 369 
AA4 2 3 N PHE A 347 ? N PHE A 366 O VAL A 361 ? O VAL A 380 
# 
_pdbx_entry_details.entry_id                   9DZ5 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 OD2 A ASP 264  ? ? O A HOH 501  ? ? 1.82 
2  1 O   A HOH 581  ? ? O A HOH 1001 ? ? 1.84 
3  1 O   A HOH 759  ? ? O A HOH 909  ? ? 1.87 
4  1 O   A HOH 754  ? ? O A HOH 959  ? ? 1.89 
5  1 O   A HOH 501  ? ? O A HOH 917  ? ? 1.90 
6  1 O   A HOH 772  ? ? O A HOH 891  ? ? 1.94 
7  1 O   A HOH 938  ? ? O A HOH 1139 ? ? 1.94 
8  1 O   A HOH 1056 ? ? O A HOH 1131 ? ? 1.96 
9  1 O   A LYS 404  ? ? O A HOH 502  ? ? 1.96 
10 1 O   A HOH 806  ? ? O A HOH 897  ? ? 2.00 
11 1 O   A HOH 939  ? ? O A HOH 1042 ? ? 2.02 
12 1 O   A HOH 1142 ? ? O A HOH 1154 ? ? 2.02 
13 1 O   A HOH 855  ? ? O A HOH 1119 ? ? 2.03 
14 1 O   A HOH 666  ? ? O A HOH 931  ? ? 2.05 
15 1 O   A HOH 863  ? ? O A HOH 1041 ? ? 2.06 
16 1 O   A HOH 750  ? ? O A HOH 779  ? ? 2.07 
17 1 O   A HOH 687  ? ? O A HOH 1024 ? ? 2.07 
18 1 O   A HOH 614  ? ? O A HOH 1045 ? ? 2.09 
19 1 O   A HOH 720  ? ? O A HOH 1041 ? ? 2.10 
20 1 OE1 A GLU 384  ? B O A HOH 503  ? ? 2.10 
21 1 O   A HOH 1005 ? ? O A HOH 1025 ? ? 2.11 
22 1 O   A HOH 794  ? ? O A HOH 1026 ? ? 2.11 
23 1 O   A HOH 680  ? ? O A HOH 954  ? ? 2.13 
24 1 O   A HOH 511  ? ? O A HOH 537  ? ? 2.14 
25 1 OE1 A GLU 34   ? ? O A HOH 504  ? ? 2.14 
26 1 O   A HOH 877  ? ? O A HOH 1023 ? ? 2.15 
27 1 O   A HOH 802  ? ? O A HOH 910  ? ? 2.16 
28 1 O   A HOH 950  ? ? O A HOH 1134 ? ? 2.16 
29 1 N   A ASN 203  ? ? O A HOH 505  ? ? 2.17 
30 1 O   A HOH 531  ? ? O A HOH 1005 ? ? 2.18 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 836  ? ? 1_555 O A HOH 934  ? ? 3_445 1.93 
2 1 O A HOH 1015 ? ? 1_555 O A HOH 1105 ? ? 3_454 2.10 
3 1 O A HOH 927  ? ? 1_555 O A HOH 927  ? ? 2_565 2.14 
4 1 O A HOH 652  ? ? 1_555 O A HOH 827  ? ? 1_565 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 41  ? ? -77.60  23.55  
2 1 GLU A 170 ? ? -58.58  -8.22  
3 1 ASP A 205 ? ? -171.23 147.44 
4 1 HIS A 255 ? ? -100.16 71.58  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1157 ? 6.20 . 
2 1 O ? A HOH 1158 ? 6.68 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -10 ? A MET 1   
2  1 Y 1 A ASN -9  ? A ASN 2   
3  1 Y 1 A GLU 165 ? A GLU 146 
4  1 Y 1 A GLU 166 ? A GLU 147 
5  1 Y 1 A LYS 167 ? A LYS 148 
6  1 Y 1 A LYS 168 ? A LYS 149 
7  1 Y 1 A SER 405 ? A SER 386 
8  1 Y 1 A LYS 406 ? A LYS 387 
9  1 Y 1 A ASP 407 ? A ASP 388 
10 1 Y 1 A HIS 408 ? A HIS 389 
11 1 Y 1 A PHE 409 ? A PHE 390 
12 1 Y 1 A GLY 410 ? A GLY 391 
13 1 Y 1 A LEU 411 ? A LEU 392 
14 1 Y 1 A GLU 412 ? A GLU 393 
15 1 Y 1 A GLY 413 ? A GLY 394 
16 1 Y 1 A ASP 414 ? A ASP 395 
17 1 Y 1 A GLU 415 ? A GLU 396 
18 1 Y 1 A GLU 416 ? A GLU 397 
19 1 Y 1 A SER 417 ? A SER 398 
20 1 Y 1 A THR 418 ? A THR 399 
21 1 Y 1 A MET 419 ? A MET 400 
22 1 Y 1 A LEU 420 ? A LEU 401 
23 1 Y 1 A GLU 421 ? A GLU 402 
24 1 Y 1 A ASP 422 ? A ASP 403 
25 1 Y 1 A SER 423 ? A SER 404 
26 1 Y 1 A VAL 424 ? A VAL 405 
27 1 Y 1 A SER 425 ? A SER 406 
28 1 Y 1 A PRO 426 ? A PRO 407 
29 1 Y 1 A LYS 427 ? A LYS 408 
30 1 Y 1 A LYS 428 ? A LYS 409 
31 1 Y 1 A SER 429 ? A SER 410 
32 1 Y 1 A THR 430 ? A THR 411 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8FSE 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DZ5 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009058 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014951 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.014657 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASN A 1 3   ? -29.23761 -57.92331 -29.73918 1.000 36.54163 ? -8   ASN A N   1 
ATOM   2    C CA  . ASN A 1 3   ? -30.43943 -57.47697 -29.03744 1.000 42.38652 ? -8   ASN A CA  1 
ATOM   3    C C   . ASN A 1 3   ? -30.74367 -55.99921 -29.34644 1.000 41.09143 ? -8   ASN A C   1 
ATOM   4    O O   . ASN A 1 3   ? -29.83333 -55.23736 -29.71251 1.000 30.70342 ? -8   ASN A O   1 
ATOM   5    C CB  . ASN A 1 3   ? -30.26648 -57.69922 -27.53119 1.000 43.95413 ? -8   ASN A CB  1 
ATOM   6    C CG  . ASN A 1 3   ? -31.55403 -58.13672 -26.84237 1.000 50.00916 ? -8   ASN A CG  1 
ATOM   7    O OD1 . ASN A 1 3   ? -32.53592 -58.50520 -27.49532 1.000 58.34814 ? -8   ASN A OD1 1 
ATOM   8    N ND2 . ASN A 1 3   ? -31.54462 -58.11503 -25.51120 1.000 48.21312 ? -8   ASN A ND2 1 
ATOM   9    N N   . ASP A 1 4   ? -32.02745 -55.62910 -29.23360 1.000 43.85565 ? -7   ASP A N   1 
ATOM   10   C CA  A ASP A 1 4   ? -32.50455 -54.26938 -29.45098 0.513 39.58323 ? -7   ASP A CA  1 
ATOM   11   C CA  B ASP A 1 4   ? -32.49820 -54.26767 -29.45168 0.487 39.58189 ? -7   ASP A CA  1 
ATOM   12   C C   . ASP A 1 4   ? -32.50941 -53.48101 -28.14437 1.000 40.80434 ? -7   ASP A C   1 
ATOM   13   O O   . ASP A 1 4   ? -32.44762 -54.03988 -27.04303 1.000 41.42455 ? -7   ASP A O   1 
ATOM   14   C CB  A ASP A 1 4   ? -33.91940 -54.26194 -30.04405 0.513 41.09726 ? -7   ASP A CB  1 
ATOM   15   C CB  B ASP A 1 4   ? -33.90729 -54.25426 -30.05765 0.487 41.09859 ? -7   ASP A CB  1 
ATOM   16   C CG  A ASP A 1 4   ? -33.97927 -54.83347 -31.44679 0.513 45.17720 ? -7   ASP A CG  1 
ATOM   17   C CG  B ASP A 1 4   ? -33.94836 -54.78678 -31.47639 0.487 45.14787 ? -7   ASP A CG  1 
ATOM   18   O OD1 A ASP A 1 4   ? -33.04629 -54.58041 -32.24181 0.513 44.80208 ? -7   ASP A OD1 1 
ATOM   19   O OD1 B ASP A 1 4   ? -33.00436 -54.51126 -32.25067 0.487 44.75842 ? -7   ASP A OD1 1 
ATOM   20   O OD2 A ASP A 1 4   ? -34.97067 -55.52896 -31.75888 0.513 47.03116 ? -7   ASP A OD2 1 
ATOM   21   O OD2 B ASP A 1 4   ? -34.93456 -55.47388 -31.82161 0.487 47.01982 ? -7   ASP A OD2 1 
ATOM   22   N N   . ASN A 1 5   ? -32.61107 -52.16747 -28.27597 1.000 33.35608 ? -6   ASN A N   1 
ATOM   23   C CA  . ASN A 1 5   ? -32.63306 -51.30566 -27.10019 1.000 29.54748 ? -6   ASN A CA  1 
ATOM   24   C C   . ASN A 1 5   ? -33.93779 -50.53146 -27.01181 1.000 27.66642 ? -6   ASN A C   1 
ATOM   25   O O   . ASN A 1 5   ? -34.12414 -49.55065 -27.75536 1.000 23.39660 ? -6   ASN A O   1 
ATOM   26   C CB  . ASN A 1 5   ? -31.43573 -50.35729 -27.12083 1.000 22.97873 ? -6   ASN A CB  1 
ATOM   27   C CG  . ASN A 1 5   ? -31.38979 -49.48069 -25.90674 1.000 26.57135 ? -6   ASN A CG  1 
ATOM   28   O OD1 . ASN A 1 5   ? -32.14458 -49.69605 -24.95590 1.000 26.77446 ? -6   ASN A OD1 1 
ATOM   29   N ND2 . ASN A 1 5   ? -30.46636 -48.52014 -25.89543 1.000 20.71714 ? -6   ASN A ND2 1 
ATOM   30   N N   . PRO A 1 6   ? -34.83795 -50.89268 -26.09354 1.000 30.24443 ? -5   PRO A N   1 
ATOM   31   C CA  . PRO A 1 6   ? -36.10713 -50.15313 -25.96759 1.000 29.34661 ? -5   PRO A CA  1 
ATOM   32   C C   . PRO A 1 6   ? -35.94842 -48.69181 -25.57450 1.000 29.22060 ? -5   PRO A C   1 
ATOM   33   O O   . PRO A 1 6   ? -36.89558 -47.92196 -25.77574 1.000 30.72158 ? -5   PRO A O   1 
ATOM   34   C CB  . PRO A 1 6   ? -36.86346 -50.93845 -24.88378 1.000 30.18784 ? -5   PRO A CB  1 
ATOM   35   C CG  . PRO A 1 6   ? -36.21910 -52.27996 -24.87503 1.000 30.37755 ? -5   PRO A CG  1 
ATOM   36   C CD  . PRO A 1 6   ? -34.77759 -52.04051 -25.17666 1.000 25.54052 ? -5   PRO A CD  1 
ATOM   37   N N   . LEU A 1 7   ? -34.80152 -48.28227 -25.02094 1.000 28.82786 ? -4   LEU A N   1 
ATOM   38   C CA  . LEU A 1 7   ? -34.56128 -46.87887 -24.67651 1.000 30.34056 ? -4   LEU A CA  1 
ATOM   39   C C   . LEU A 1 7   ? -34.27319 -45.99399 -25.87513 1.000 31.40146 ? -4   LEU A C   1 
ATOM   40   O O   . LEU A 1 7   ? -34.25944 -44.76450 -25.72964 1.000 28.61907 ? -4   LEU A O   1 
ATOM   41   C CB  . LEU A 1 7   ? -33.37885 -46.73144 -23.71186 1.000 32.49133 ? -4   LEU A CB  1 
ATOM   42   C CG  . LEU A 1 7   ? -33.29513 -47.53675 -22.43126 1.000 31.96988 ? -4   LEU A CG  1 
ATOM   43   C CD1 . LEU A 1 7   ? -31.95592 -47.27108 -21.78590 1.000 30.80776 ? -4   LEU A CD1 1 
ATOM   44   C CD2 . LEU A 1 7   ? -34.38998 -47.01285 -21.53790 1.000 32.46356 ? -4   LEU A CD2 1 
ATOM   45   N N   . PHE A 1 8   ? -34.01757 -46.57235 -27.03632 1.000 26.32361 ? -3   PHE A N   1 
ATOM   46   C CA  . PHE A 1 8   ? -33.52222 -45.78782 -28.15446 1.000 21.54143 ? -3   PHE A CA  1 
ATOM   47   C C   . PHE A 1 8   ? -34.61105 -44.89717 -28.74089 1.000 26.18743 ? -3   PHE A C   1 
ATOM   48   O O   . PHE A 1 8   ? -35.72106 -45.35594 -29.01799 1.000 23.19890 ? -3   PHE A O   1 
ATOM   49   C CB  . PHE A 1 8   ? -32.98535 -46.72123 -29.23765 1.000 23.19696 ? -3   PHE A CB  1 
ATOM   50   C CG  . PHE A 1 8   ? -32.37208 -46.00022 -30.38773 1.000 22.08734 ? -3   PHE A CG  1 
ATOM   51   C CD1 . PHE A 1 8   ? -31.06689 -45.55266 -30.31217 1.000 20.32074 ? -3   PHE A CD1 1 
ATOM   52   C CD2 . PHE A 1 8   ? -33.11597 -45.73055 -31.52890 1.000 20.14640 ? -3   PHE A CD2 1 
ATOM   53   C CE1 . PHE A 1 8   ? -30.49400 -44.88055 -31.37611 1.000 18.78833 ? -3   PHE A CE1 1 
ATOM   54   C CE2 . PHE A 1 8   ? -32.56879 -45.04328 -32.57270 1.000 20.23669 ? -3   PHE A CE2 1 
ATOM   55   C CZ  . PHE A 1 8   ? -31.24974 -44.61518 -32.50585 1.000 21.26392 ? -3   PHE A CZ  1 
ATOM   56   N N   . LYS A 1 9   ? -34.27078 -43.63123 -28.98736 1.000 24.14033 ? -2   LYS A N   1 
ATOM   57   C CA  . LYS A 1 9   ? -35.09993 -42.73203 -29.77961 1.000 28.87418 ? -2   LYS A CA  1 
ATOM   58   C C   . LYS A 1 9   ? -34.22786 -42.11149 -30.85677 1.000 23.29794 ? -2   LYS A C   1 
ATOM   59   O O   . LYS A 1 9   ? -33.05364 -41.81235 -30.61218 1.000 24.02796 ? -2   LYS A O   1 
ATOM   60   C CB  . LYS A 1 9   ? -35.70344 -41.64320 -28.90212 1.000 29.47786 ? -2   LYS A CB  1 
ATOM   61   C CG  . LYS A 1 9   ? -36.79953 -42.15122 -27.98013 1.000 34.28541 ? -2   LYS A CG  1 
ATOM   62   C CD  . LYS A 1 9   ? -37.77581 -41.04964 -27.63221 1.000 35.92689 ? -2   LYS A CD  1 
ATOM   63   C CE  . LYS A 1 9   ? -38.66390 -41.46714 -26.46763 1.000 38.25346 ? -2   LYS A CE  1 
ATOM   64   N NZ  . LYS A 1 9   ? -39.46089 -40.31363 -25.96078 1.000 38.40625 ? -2   LYS A NZ  1 
ATOM   65   N N   . SER A 1 10  ? -34.80074 -41.90786 -32.04300 1.000 23.13360 ? -1   SER A N   1 
ATOM   66   C CA  . SER A 1 10  ? -34.05142 -41.30316 -33.13530 1.000 21.38164 ? -1   SER A CA  1 
ATOM   67   C C   . SER A 1 10  ? -33.41669 -39.98276 -32.70031 1.000 25.95884 ? -1   SER A C   1 
ATOM   68   O O   . SER A 1 10  ? -34.00313 -39.21408 -31.93224 1.000 24.77572 ? -1   SER A O   1 
ATOM   69   C CB  . SER A 1 10  ? -34.97257 -41.08267 -34.33752 1.000 27.95778 ? -1   SER A CB  1 
ATOM   70   O OG  . SER A 1 10  ? -34.50344 -40.01729 -35.13957 1.000 23.40785 ? -1   SER A OG  1 
ATOM   71   N N   . ALA A 1 11  ? -32.19352 -39.73380 -33.18718 1.000 19.45884 ? 0    ALA A N   1 
ATOM   72   C CA  . ALA A 1 11  ? -31.48329 -38.49896 -32.87313 1.000 19.43371 ? 0    ALA A CA  1 
ATOM   73   C C   . ALA A 1 11  ? -32.24834 -37.25882 -33.32009 1.000 26.99370 ? 0    ALA A C   1 
ATOM   74   O O   . ALA A 1 11  ? -31.95149 -36.15414 -32.84775 1.000 26.87054 ? 0    ALA A O   1 
ATOM   75   C CB  . ALA A 1 11  ? -30.10497 -38.49836 -33.53162 1.000 19.02363 ? 0    ALA A CB  1 
ATOM   76   N N   . MET A 1 12  ? -33.21644 -37.41307 -34.22316 1.000 25.70411 ? 1    MET A N   1 
ATOM   77   C CA  . MET A 1 12  ? -33.94295 -36.26748 -34.76235 1.000 28.94771 ? 1    MET A CA  1 
ATOM   78   C C   . MET A 1 12  ? -35.13968 -35.87322 -33.91527 1.000 29.67258 ? 1    MET A C   1 
ATOM   79   O O   . MET A 1 12  ? -35.63806 -34.75355 -34.06508 1.000 34.79135 ? 1    MET A O   1 
ATOM   80   C CB  . MET A 1 12  ? -34.42666 -36.55438 -36.19407 1.000 30.80587 ? 1    MET A CB  1 
ATOM   81   C CG  . MET A 1 12  ? -33.33878 -36.97957 -37.16102 1.000 31.27630 ? 1    MET A CG  1 
ATOM   82   S SD  . MET A 1 12  ? -32.17901 -35.64363 -37.54663 1.000 47.66269 ? 1    MET A SD  1 
ATOM   83   C CE  . MET A 1 12  ? -33.24896 -34.45092 -38.35694 1.000 39.39771 ? 1    MET A CE  1 
ATOM   84   N N   . VAL A 1 13  ? -35.59974 -36.74840 -33.02392 1.000 24.57508 ? 2    VAL A N   1 
ATOM   85   C CA  . VAL A 1 13  ? -36.81827 -36.51623 -32.26260 1.000 28.69102 ? 2    VAL A CA  1 
ATOM   86   C C   . VAL A 1 13  ? -36.55853 -36.30961 -30.77954 1.000 27.18505 ? 2    VAL A C   1 
ATOM   87   O O   . VAL A 1 13  ? -37.52081 -36.12929 -30.02325 1.000 29.38891 ? 2    VAL A O   1 
ATOM   88   C CB  . VAL A 1 13  ? -37.83466 -37.65378 -32.47151 1.000 32.41026 ? 2    VAL A CB  1 
ATOM   89   C CG1 . VAL A 1 13  ? -37.94216 -38.00431 -33.96480 1.000 34.34180 ? 2    VAL A CG1 1 
ATOM   90   C CG2 . VAL A 1 13  ? -37.45084 -38.88321 -31.64190 1.000 29.36799 ? 2    VAL A CG2 1 
ATOM   91   N N   . ALA A 1 14  ? -35.30144 -36.32864 -30.33267 1.000 22.47031 ? 3    ALA A N   1 
ATOM   92   C CA  . ALA A 1 14  ? -35.01590 -36.06800 -28.92413 1.000 24.72269 ? 3    ALA A CA  1 
ATOM   93   C C   . ALA A 1 14  ? -33.68893 -35.34246 -28.79123 1.000 22.62633 ? 3    ALA A C   1 
ATOM   94   O O   . ALA A 1 14  ? -32.79876 -35.47864 -29.63130 1.000 20.57213 ? 3    ALA A O   1 
ATOM   95   C CB  . ALA A 1 14  ? -34.97534 -37.35135 -28.08676 1.000 24.75264 ? 3    ALA A CB  1 
ATOM   96   N N   . LEU A 1 15  ? -33.56303 -34.57536 -27.71217 1.000 20.46692 ? 4    LEU A N   1 
ATOM   97   C CA  . LEU A 1 15  ? -32.33735 -33.86440 -27.39725 1.000 20.33194 ? 4    LEU A CA  1 
ATOM   98   C C   . LEU A 1 15  ? -31.61914 -34.65889 -26.31853 1.000 20.95051 ? 4    LEU A C   1 
ATOM   99   O O   . LEU A 1 15  ? -32.19265 -34.92517 -25.26095 1.000 19.90327 ? 4    LEU A O   1 
ATOM   100  C CB  . LEU A 1 15  ? -32.65556 -32.45765 -26.90680 1.000 20.32192 ? 4    LEU A CB  1 
ATOM   101  C CG  . LEU A 1 15  ? -32.65535 -31.31296 -27.92084 1.000 23.69122 ? 4    LEU A CG  1 
ATOM   102  C CD1 . LEU A 1 15  ? -32.77948 -29.99535 -27.14996 1.000 23.11623 ? 4    LEU A CD1 1 
ATOM   103  C CD2 . LEU A 1 15  ? -31.40978 -31.29081 -28.79322 1.000 21.03377 ? 4    LEU A CD2 1 
ATOM   104  N N   . SER A 1 16  ? -30.38610 -35.04651 -26.59850 1.000 17.40279 ? 5    SER A N   1 
ATOM   105  C CA  . SER A 1 16  ? -29.53010 -35.75718 -25.65517 1.000 17.64439 ? 5    SER A CA  1 
ATOM   106  C C   . SER A 1 16  ? -28.55742 -34.74799 -25.06768 1.000 17.36757 ? 5    SER A C   1 
ATOM   107  O O   . SER A 1 16  ? -27.61295 -34.33071 -25.74228 1.000 20.97575 ? 5    SER A O   1 
ATOM   108  C CB  . SER A 1 16  ? -28.78552 -36.89172 -26.36556 1.000 20.48091 ? 5    SER A CB  1 
ATOM   109  O OG  . SER A 1 16  ? -28.07035 -37.68913 -25.44767 1.000 23.83572 ? 5    SER A OG  1 
ATOM   110  N N   . LEU A 1 17  ? -28.77778 -34.34869 -23.81612 1.000 18.16748 ? 6    LEU A N   1 
ATOM   111  C CA  . LEU A 1 17  ? -27.98653 -33.28642 -23.21514 1.000 16.49985 ? 6    LEU A CA  1 
ATOM   112  C C   . LEU A 1 17  ? -27.22908 -33.80185 -22.00101 1.000 20.06686 ? 6    LEU A C   1 
ATOM   113  O O   . LEU A 1 17  ? -27.76233 -34.59128 -21.21345 1.000 19.21636 ? 6    LEU A O   1 
ATOM   114  C CB  . LEU A 1 17  ? -28.87252 -32.10000 -22.82282 1.000 18.78601 ? 6    LEU A CB  1 
ATOM   115  C CG  . LEU A 1 17  ? -29.63962 -31.54581 -24.02865 1.000 19.11951 ? 6    LEU A CG  1 
ATOM   116  C CD1 . LEU A 1 17  ? -30.76733 -30.61160 -23.59509 1.000 19.51267 ? 6    LEU A CD1 1 
ATOM   117  C CD2 . LEU A 1 17  ? -28.70931 -30.86888 -25.04290 1.000 21.27145 ? 6    LEU A CD2 1 
ATOM   118  N N   . LYS A 1 18  ? -25.97939 -33.35678 -21.86069 1.000 19.24982 ? 7    LYS A N   1 
ATOM   119  C CA  . LYS A 1 18  ? -25.21019 -33.61258 -20.64662 1.000 18.38216 ? 7    LYS A CA  1 
ATOM   120  C C   . LYS A 1 18  ? -25.56586 -32.56296 -19.60605 1.000 22.38091 ? 7    LYS A C   1 
ATOM   121  O O   . LYS A 1 18  ? -25.42916 -31.36190 -19.85972 1.000 16.77966 ? 7    LYS A O   1 
ATOM   122  C CB  . LYS A 1 18  ? -23.70589 -33.59988 -20.92441 1.000 20.60501 ? 7    LYS A CB  1 
ATOM   123  C CG  . LYS A 1 18  ? -23.29150 -34.41847 -22.15634 1.000 25.31142 ? 7    LYS A CG  1 
ATOM   124  C CD  . LYS A 1 18  ? -21.78824 -34.59300 -22.23875 1.000 32.21894 ? 7    LYS A CD  1 
ATOM   125  C CE  . LYS A 1 18  ? -21.35957 -34.96934 -23.65656 1.000 35.05377 ? 7    LYS A CE  1 
ATOM   126  N NZ  . LYS A 1 18  ? -20.17707 -35.86827 -23.65124 1.000 46.64578 ? 7    LYS A NZ  1 
ATOM   127  N N   . ILE A 1 19  ? -25.99860 -33.01443 -18.43327 1.000 17.58913 ? 8    ILE A N   1 
ATOM   128  C CA  . ILE A 1 19  ? -26.37654 -32.12748 -17.34067 1.000 18.93437 ? 8    ILE A CA  1 
ATOM   129  C C   . ILE A 1 19  ? -25.24598 -32.12430 -16.32986 1.000 18.24699 ? 8    ILE A C   1 
ATOM   130  O O   . ILE A 1 19  ? -24.88695 -33.17903 -15.78939 1.000 18.40289 ? 8    ILE A O   1 
ATOM   131  C CB  . ILE A 1 19  ? -27.68392 -32.57642 -16.67550 1.000 17.41959 ? 8    ILE A CB  1 
ATOM   132  C CG1 . ILE A 1 19  ? -28.76309 -32.82360 -17.73476 1.000 17.93174 ? 8    ILE A CG1 1 
ATOM   133  C CG2 . ILE A 1 19  ? -28.09809 -31.55038 -15.61415 1.000 18.71176 ? 8    ILE A CG2 1 
ATOM   134  C CD1 . ILE A 1 19  ? -29.06899 -31.62408 -18.62538 1.000 14.42960 ? 8    ILE A CD1 1 
ATOM   135  N N   . SER A 1 20  ? -24.69686 -30.94900 -16.05788 1.000 15.11870 ? 9    SER A N   1 
ATOM   136  C CA  . SER A 1 20  ? -23.53858 -30.82037 -15.19006 1.000 16.08242 ? 9    SER A CA  1 
ATOM   137  C C   . SER A 1 20  ? -23.95543 -30.11985 -13.89960 1.000 21.65721 ? 9    SER A C   1 
ATOM   138  O O   . SER A 1 20  ? -24.59343 -29.06037 -13.93279 1.000 18.13461 ? 9    SER A O   1 
ATOM   139  C CB  . SER A 1 20  ? -22.41632 -30.05642 -15.89228 1.000 22.28932 ? 9    SER A CB  1 
ATOM   140  O OG  . SER A 1 20  ? -21.57010 -29.41748 -14.96802 1.000 29.23178 ? 9    SER A OG  1 
ATOM   141  N N   . ILE A 1 21  ? -23.63510 -30.73623 -12.76608 1.000 18.98136 ? 10   ILE A N   1 
ATOM   142  C CA  . ILE A 1 21  ? -23.88776 -30.16489 -11.44510 1.000 24.97159 ? 10   ILE A CA  1 
ATOM   143  C C   . ILE A 1 21  ? -22.59380 -30.34364 -10.67012 1.000 32.08104 ? 10   ILE A C   1 
ATOM   144  O O   . ILE A 1 21  ? -22.26673 -31.46450 -10.25689 1.000 26.60351 ? 10   ILE A O   1 
ATOM   145  C CB  . ILE A 1 21  ? -25.06002 -30.84876 -10.71759 1.000 27.20684 ? 10   ILE A CB  1 
ATOM   146  C CG1 . ILE A 1 21  ? -26.22183 -31.15572 -11.67446 1.000 24.05109 ? 10   ILE A CG1 1 
ATOM   147  C CG2 . ILE A 1 21  ? -25.51809 -30.01246 -9.52579  1.000 28.86120 ? 10   ILE A CG2 1 
ATOM   148  C CD1 . ILE A 1 21  ? -27.53009 -31.49727 -10.94726 1.000 24.70833 ? 10   ILE A CD1 1 
ATOM   149  N N   . GLY A 1 22  ? -21.85103 -29.25756 -10.49006 1.000 34.78304 ? 11   GLY A N   1 
ATOM   150  C CA  . GLY A 1 22  ? -20.50511 -29.35903 -9.95849  1.000 37.70996 ? 11   GLY A CA  1 
ATOM   151  C C   . GLY A 1 22  ? -19.65663 -30.36761 -10.71073 1.000 38.35531 ? 11   GLY A C   1 
ATOM   152  O O   . GLY A 1 22  ? -19.39727 -30.21702 -11.91120 1.000 35.41522 ? 11   GLY A O   1 
ATOM   153  N N   . ASN A 1 23  ? -19.24707 -31.42609 -10.01543 1.000 34.98859 ? 12   ASN A N   1 
ATOM   154  C CA  . ASN A 1 23  ? -18.41773 -32.46663 -10.60685 1.000 35.08129 ? 12   ASN A CA  1 
ATOM   155  C C   . ASN A 1 23  ? -19.22368 -33.61449 -11.20423 1.000 38.07598 ? 12   ASN A C   1 
ATOM   156  O O   . ASN A 1 23  ? -18.63578 -34.50285 -11.83261 1.000 36.89212 ? 12   ASN A O   1 
ATOM   157  C CB  . ASN A 1 23  ? -17.44248 -33.01777 -9.55548  1.000 36.69990 ? 12   ASN A CB  1 
ATOM   158  N N   . VAL A 1 24  ? -20.53465 -33.62886 -11.02649 1.000 30.04507 ? 13   VAL A N   1 
ATOM   159  C CA  . VAL A 1 24  ? -21.37628 -34.69938 -11.54878 1.000 28.61121 ? 13   VAL A CA  1 
ATOM   160  C C   . VAL A 1 24  ? -21.81623 -34.33941 -12.96488 1.000 29.21218 ? 13   VAL A C   1 
ATOM   161  O O   . VAL A 1 24  ? -22.12642 -33.17776 -13.25667 1.000 21.06718 ? 13   VAL A O   1 
ATOM   162  C CB  . VAL A 1 24  ? -22.58443 -34.93925 -10.62191 1.000 28.16097 ? 13   VAL A CB  1 
ATOM   163  C CG1 . VAL A 1 24  ? -23.56495 -35.91914 -11.25140 1.000 31.86295 ? 13   VAL A CG1 1 
ATOM   164  C CG2 . VAL A 1 24  ? -22.11303 -35.47245 -9.26644  1.000 32.77058 ? 13   VAL A CG2 1 
ATOM   165  N N   . VAL A 1 25  ? -21.82027 -35.32883 -13.85853 1.000 23.89489 ? 14   VAL A N   1 
ATOM   166  C CA  . VAL A 1 25  ? -22.35100 -35.15722 -15.20926 1.000 24.95972 ? 14   VAL A CA  1 
ATOM   167  C C   . VAL A 1 25  ? -23.19530 -36.38052 -15.54605 1.000 30.72911 ? 14   VAL A C   1 
ATOM   168  O O   . VAL A 1 25  ? -22.73155 -37.51980 -15.41146 1.000 32.42090 ? 14   VAL A O   1 
ATOM   169  C CB  . VAL A 1 25  ? -21.23990 -34.96967 -16.26164 1.000 29.62120 ? 14   VAL A CB  1 
ATOM   170  C CG1 . VAL A 1 25  ? -21.83412 -35.01911 -17.64949 1.000 28.39193 ? 14   VAL A CG1 1 
ATOM   171  C CG2 . VAL A 1 25  ? -20.51650 -33.65260 -16.06253 1.000 28.00703 ? 14   VAL A CG2 1 
ATOM   172  N N   . LYS A 1 26  ? -24.43896 -36.15080 -15.96165 1.000 20.19650 ? 15   LYS A N   1 
ATOM   173  C CA  . LYS A 1 26  ? -25.32705 -37.21210 -16.41216 1.000 22.55171 ? 15   LYS A CA  1 
ATOM   174  C C   . LYS A 1 26  ? -25.92483 -36.81005 -17.75176 1.000 26.34533 ? 15   LYS A C   1 
ATOM   175  O O   . LYS A 1 26  ? -26.36332 -35.67014 -17.92299 1.000 17.99097 ? 15   LYS A O   1 
ATOM   176  C CB  . LYS A 1 26  ? -26.45090 -37.47488 -15.38473 1.000 24.99657 ? 15   LYS A CB  1 
ATOM   177  C CG  . LYS A 1 26  ? -25.96542 -38.06192 -14.06220 1.000 33.62988 ? 15   LYS A CG  1 
ATOM   178  C CD  . LYS A 1 26  ? -25.07734 -39.27577 -14.29093 1.000 38.92199 ? 15   LYS A CD  1 
ATOM   179  C CE  . LYS A 1 26  ? -24.27691 -39.64534 -13.04383 1.000 42.03516 ? 15   LYS A CE  1 
ATOM   180  N NZ  . LYS A 1 26  ? -25.11045 -40.27810 -11.99154 1.000 42.42170 ? 15   LYS A NZ  1 
ATOM   181  N N   . THR A 1 27  ? -25.94303 -37.73563 -18.70719 1.000 26.57308 ? 16   THR A N   1 
ATOM   182  C CA  . THR A 1 27  ? -26.58554 -37.46025 -19.98593 1.000 24.91821 ? 16   THR A CA  1 
ATOM   183  C C   . THR A 1 27  ? -28.05115 -37.84331 -19.89411 1.000 19.98038 ? 16   THR A C   1 
ATOM   184  O O   . THR A 1 27  ? -28.40430 -38.88682 -19.33233 1.000 22.85950 ? 16   THR A O   1 
ATOM   185  C CB  . THR A 1 27  ? -25.89920 -38.20526 -21.13723 1.000 26.86010 ? 16   THR A CB  1 
ATOM   186  O OG1 . THR A 1 27  ? -24.55858 -37.73974 -21.25590 1.000 26.10628 ? 16   THR A OG1 1 
ATOM   187  C CG2 . THR A 1 27  ? -26.63245 -37.95310 -22.45091 1.000 19.70199 ? 16   THR A CG2 1 
ATOM   188  N N   . MET A 1 28  ? -28.90390 -36.98554 -20.44992 1.000 18.58948 ? 17   MET A N   1 
ATOM   189  C CA  . MET A 1 28  ? -30.31177 -37.01151 -20.13679 1.000 20.93463 ? 17   MET A CA  1 
ATOM   190  C C   . MET A 1 28  ? -31.05771 -36.72671 -21.43927 1.000 20.25040 ? 17   MET A C   1 
ATOM   191  O O   . MET A 1 28  ? -30.58952 -35.91839 -22.24229 1.000 17.05357 ? 17   MET A O   1 
ATOM   192  C CB  . MET A 1 28  ? -30.47718 -35.96067 -19.02946 1.000 24.45038 ? 17   MET A CB  1 
ATOM   193  C CG  . MET A 1 28  ? -30.57042 -36.53916 -17.63079 1.000 18.90134 ? 17   MET A CG  1 
ATOM   194  S SD  . MET A 1 28  ? -31.39803 -35.48495 -16.44062 1.000 18.78735 ? 17   MET A SD  1 
ATOM   195  C CE  . MET A 1 28  ? -33.11035 -35.92443 -16.61385 1.000 19.52529 ? 17   MET A CE  1 
ATOM   196  N N   . GLN A 1 29  ? -32.17848 -37.41915 -21.67422 1.000 18.89314 ? 18   GLN A N   1 
ATOM   197  C CA  . GLN A 1 29  ? -32.92790 -37.32618 -22.92630 1.000 20.90390 ? 18   GLN A CA  1 
ATOM   198  C C   . GLN A 1 29  ? -34.17790 -36.46827 -22.72857 1.000 20.61205 ? 18   GLN A C   1 
ATOM   199  O O   . GLN A 1 29  ? -34.94119 -36.68827 -21.78139 1.000 20.96409 ? 18   GLN A O   1 
ATOM   200  C CB  . GLN A 1 29  ? -33.30996 -38.72846 -23.42594 1.000 22.91063 ? 18   GLN A CB  1 
ATOM   201  C CG  . GLN A 1 29  ? -34.21341 -38.77740 -24.68207 1.000 28.74976 ? 18   GLN A CG  1 
ATOM   202  C CD  . GLN A 1 29  ? -34.47118 -40.20725 -25.19466 1.000 29.75209 ? 18   GLN A CD  1 
ATOM   203  O OE1 . GLN A 1 29  ? -33.68863 -40.75047 -25.99059 1.000 30.76758 ? 18   GLN A OE1 1 
ATOM   204  N NE2 . GLN A 1 29  ? -35.57101 -40.81149 -24.74312 1.000 28.19186 ? 18   GLN A NE2 1 
ATOM   205  N N   . PHE A 1 30  ? -34.39368 -35.49323 -23.62333 1.000 19.58486 ? 19   PHE A N   1 
ATOM   206  C CA  . PHE A 1 30  ? -35.49464 -34.54192 -23.49197 1.000 17.45655 ? 19   PHE A CA  1 
ATOM   207  C C   . PHE A 1 30  ? -36.30227 -34.44303 -24.78029 1.000 19.98019 ? 19   PHE A C   1 
ATOM   208  O O   . PHE A 1 30  ? -35.73813 -34.40287 -25.87644 1.000 20.39016 ? 19   PHE A O   1 
ATOM   209  C CB  . PHE A 1 30  ? -34.97402 -33.12602 -23.15227 1.000 17.63046 ? 19   PHE A CB  1 
ATOM   210  C CG  . PHE A 1 30  ? -34.23737 -33.04439 -21.84725 1.000 20.14208 ? 19   PHE A CG  1 
ATOM   211  C CD1 . PHE A 1 30  ? -34.91291 -32.79472 -20.66459 1.000 17.69603 ? 19   PHE A CD1 1 
ATOM   212  C CD2 . PHE A 1 30  ? -32.85847 -33.19417 -21.80720 1.000 15.49121 ? 19   PHE A CD2 1 
ATOM   213  C CE1 . PHE A 1 30  ? -34.22773 -32.70921 -19.46987 1.000 14.54620 ? 19   PHE A CE1 1 
ATOM   214  C CE2 . PHE A 1 30  ? -32.17508 -33.11972 -20.60046 1.000 18.22459 ? 19   PHE A CE2 1 
ATOM   215  C CZ  . PHE A 1 30  ? -32.86165 -32.87700 -19.43775 1.000 15.54684 ? 19   PHE A CZ  1 
ATOM   216  N N   . GLU A 1 31  ? -37.61751 -34.36625 -24.64509 1.000 20.29490 ? 20   GLU A N   1 
ATOM   217  C CA  . GLU A 1 31  ? -38.43337 -33.89473 -25.75369 1.000 22.34370 ? 20   GLU A CA  1 
ATOM   218  C C   . GLU A 1 31  ? -38.05991 -32.44004 -26.04097 1.000 20.50466 ? 20   GLU A C   1 
ATOM   219  O O   . GLU A 1 31  ? -38.00112 -31.62596 -25.10449 1.000 17.75779 ? 20   GLU A O   1 
ATOM   220  C CB  . GLU A 1 31  ? -39.91441 -34.02154 -25.41788 1.000 22.40139 ? 20   GLU A CB  1 
ATOM   221  C CG  . GLU A 1 31  ? -40.79315 -34.43067 -26.61032 1.000 31.69694 ? 20   GLU A CG  1 
ATOM   222  C CD  . GLU A 1 31  ? -40.93851 -33.33369 -27.65873 1.000 36.79738 ? 20   GLU A CD  1 
ATOM   223  O OE1 . GLU A 1 31  ? -41.02328 -33.66771 -28.86287 1.000 43.01543 ? 20   GLU A OE1 1 
ATOM   224  O OE2 . GLU A 1 31  ? -40.98246 -32.13585 -27.28561 1.000 34.70609 ? 20   GLU A OE2 1 
ATOM   225  N N   . PRO A 1 32  ? -37.74758 -32.07863 -27.29238 1.000 20.55063 ? 21   PRO A N   1 
ATOM   226  C CA  . PRO A 1 32  ? -37.11223 -30.77153 -27.52072 1.000 17.96024 ? 21   PRO A CA  1 
ATOM   227  C C   . PRO A 1 32  ? -38.01011 -29.59138 -27.23121 1.000 18.70168 ? 21   PRO A C   1 
ATOM   228  O O   . PRO A 1 32  ? -37.49484 -28.47932 -27.08816 1.000 19.97812 ? 21   PRO A O   1 
ATOM   229  C CB  . PRO A 1 32  ? -36.71219 -30.82348 -29.00426 1.000 23.19982 ? 21   PRO A CB  1 
ATOM   230  C CG  . PRO A 1 32  ? -36.51697 -32.26595 -29.27943 1.000 24.42403 ? 21   PRO A CG  1 
ATOM   231  C CD  . PRO A 1 32  ? -37.63403 -32.94671 -28.47838 1.000 23.27038 ? 21   PRO A CD  1 
ATOM   232  N N   . SER A 1 33  ? -39.32495 -29.78036 -27.14539 1.000 17.31989 ? 22   SER A N   1 
ATOM   233  C CA  . SER A 1 33  ? -40.23241 -28.69358 -26.80236 1.000 16.57448 ? 22   SER A CA  1 
ATOM   234  C C   . SER A 1 33  ? -40.41101 -28.53376 -25.30083 1.000 18.42641 ? 22   SER A C   1 
ATOM   235  O O   . SER A 1 33  ? -41.18437 -27.67169 -24.86843 1.000 18.34249 ? 22   SER A O   1 
ATOM   236  C CB  . SER A 1 33  ? -41.59504 -28.91972 -27.45815 1.000 25.26343 ? 22   SER A CB  1 
ATOM   237  O OG  . SER A 1 33  ? -41.42010 -29.19012 -28.83889 1.000 29.45999 ? 22   SER A OG  1 
ATOM   238  N N   . THR A 1 34  ? -39.72079 -29.34901 -24.51417 1.000 15.16737 ? 23   THR A N   1 
ATOM   239  C CA  . THR A 1 34  ? -39.79484 -29.26729 -23.06386 1.000 17.05264 ? 23   THR A CA  1 
ATOM   240  C C   . THR A 1 34  ? -39.40681 -27.87378 -22.62183 1.000 15.93162 ? 23   THR A C   1 
ATOM   241  O O   . THR A 1 34  ? -38.38639 -27.32903 -23.06147 1.000 15.66287 ? 23   THR A O   1 
ATOM   242  C CB  . THR A 1 34  ? -38.85256 -30.27782 -22.41845 1.000 17.74117 ? 23   THR A CB  1 
ATOM   243  O OG1 . THR A 1 34  ? -39.17081 -31.60395 -22.86342 1.000 16.01790 ? 23   THR A OG1 1 
ATOM   244  C CG2 . THR A 1 34  ? -38.95489 -30.21282 -20.88246 1.000 18.93310 ? 23   THR A CG2 1 
ATOM   245  N N   . MET A 1 35  ? -40.21032 -27.30294 -21.73698 1.000 15.72852 ? 24   MET A N   1 
ATOM   246  C CA  . MET A 1 35  ? -39.87545 -25.98723 -21.23076 1.000 19.92270 ? 24   MET A CA  1 
ATOM   247  C C   . MET A 1 35  ? -38.79483 -26.10430 -20.16866 1.000 15.15918 ? 24   MET A C   1 
ATOM   248  O O   . MET A 1 35  ? -38.67734 -27.12283 -19.48507 1.000 18.44204 ? 24   MET A O   1 
ATOM   249  C CB  . MET A 1 35  ? -41.15638 -25.30707 -20.74938 1.000 22.99127 ? 24   MET A CB  1 
ATOM   250  C CG  . MET A 1 35  ? -41.75145 -24.58744 -21.97179 1.000 29.67525 ? 24   MET A CG  1 
ATOM   251  S SD  . MET A 1 35  ? -43.09220 -23.41979 -21.82981 1.000 49.11625 ? 24   MET A SD  1 
ATOM   252  C CE  . MET A 1 35  ? -43.72474 -23.87203 -20.28002 1.000 28.39205 ? 24   MET A CE  1 
ATOM   253  N N   . VAL A 1 36  ? -37.93943 -25.07940 -20.11019 1.000 15.27443 ? 25   VAL A N   1 
ATOM   254  C CA  . VAL A 1 36  ? -36.81856 -25.07669 -19.17565 1.000 13.82415 ? 25   VAL A CA  1 
ATOM   255  C C   . VAL A 1 36  ? -37.26519 -25.43280 -17.75142 1.000 13.91664 ? 25   VAL A C   1 
ATOM   256  O O   . VAL A 1 36  ? -36.62064 -26.23917 -17.08029 1.000 13.85978 ? 25   VAL A O   1 
ATOM   257  C CB  . VAL A 1 36  ? -36.09301 -23.71667 -19.23853 1.000 14.34833 ? 25   VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 36  ? -35.16861 -23.54000 -18.04725 1.000 17.29576 ? 25   VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 36  ? -35.29697 -23.62076 -20.55049 1.000 14.74980 ? 25   VAL A CG2 1 
ATOM   260  N N   . TYR A 1 37  ? -38.38164 -24.86315 -17.26862 1.000 14.69734 ? 26   TYR A N   1 
ATOM   261  C CA  A TYR A 1 37  ? -38.87105 -25.15783 -15.91650 0.551 18.19137 ? 26   TYR A CA  1 
ATOM   262  C CA  B TYR A 1 37  ? -38.74426 -25.18156 -15.88800 0.449 18.21549 ? 26   TYR A CA  1 
ATOM   263  C C   . TYR A 1 37  ? -39.13006 -26.64901 -15.72216 1.000 18.72312 ? 26   TYR A C   1 
ATOM   264  O O   . TYR A 1 37  ? -38.85624 -27.22365 -14.65687 1.000 16.53971 ? 26   TYR A O   1 
ATOM   265  C CB  A TYR A 1 37  ? -40.15165 -24.35611 -15.67589 0.551 20.99909 ? 26   TYR A CB  1 
ATOM   266  C CB  B TYR A 1 37  ? -39.85619 -24.27406 -15.34885 0.449 20.95433 ? 26   TYR A CB  1 
ATOM   267  C CG  A TYR A 1 37  ? -40.76456 -24.44464 -14.29943 0.551 20.42402 ? 26   TYR A CG  1 
ATOM   268  C CG  B TYR A 1 37  ? -41.24238 -24.51373 -15.88557 0.449 22.53177 ? 26   TYR A CG  1 
ATOM   269  C CD1 A TYR A 1 37  ? -40.38512 -23.57490 -13.28234 0.551 24.51293 ? 26   TYR A CD1 1 
ATOM   270  C CD1 B TYR A 1 37  ? -42.06353 -25.49078 -15.33210 0.449 23.73648 ? 26   TYR A CD1 1 
ATOM   271  C CD2 A TYR A 1 37  ? -41.75354 -25.38074 -14.02744 0.551 24.34103 ? 26   TYR A CD2 1 
ATOM   272  C CD2 B TYR A 1 37  ? -41.76647 -23.70940 -16.87868 0.449 21.59324 ? 26   TYR A CD2 1 
ATOM   273  C CE1 A TYR A 1 37  ? -40.96565 -23.64486 -12.03256 0.551 23.99030 ? 26   TYR A CE1 1 
ATOM   274  C CE1 B TYR A 1 37  ? -43.34524 -25.69829 -15.80161 0.449 24.31057 ? 26   TYR A CE1 1 
ATOM   275  C CE2 A TYR A 1 37  ? -42.34324 -25.45805 -12.77432 0.551 27.22606 ? 26   TYR A CE2 1 
ATOM   276  C CE2 B TYR A 1 37  ? -43.04036 -23.89798 -17.32648 0.449 23.84333 ? 26   TYR A CE2 1 
ATOM   277  C CZ  A TYR A 1 37  ? -41.94060 -24.58890 -11.78152 0.551 27.13399 ? 26   TYR A CZ  1 
ATOM   278  C CZ  B TYR A 1 37  ? -43.82632 -24.90268 -16.80573 0.449 25.81840 ? 26   TYR A CZ  1 
ATOM   279  O OH  A TYR A 1 37  ? -42.52312 -24.66699 -10.53707 0.551 32.43545 ? 26   TYR A OH  1 
ATOM   280  O OH  B TYR A 1 37  ? -45.10382 -25.09857 -17.27877 0.449 33.65286 ? 26   TYR A OH  1 
ATOM   281  N N   . ASP A 1 38  ? -39.71111 -27.28737 -16.73782 1.000 18.14595 ? 27   ASP A N   1 
ATOM   282  C CA  . ASP A 1 38  ? -39.99776 -28.71551 -16.63578 1.000 19.04890 ? 27   ASP A CA  1 
ATOM   283  C C   . ASP A 1 38  ? -38.74777 -29.57288 -16.79651 1.000 18.25480 ? 27   ASP A C   1 
ATOM   284  O O   . ASP A 1 38  ? -38.65925 -30.65357 -16.19785 1.000 17.98902 ? 27   ASP A O   1 
ATOM   285  C CB  . ASP A 1 38  ? -41.05131 -29.12190 -17.67168 1.000 22.28872 ? 27   ASP A CB  1 
ATOM   286  C CG  . ASP A 1 38  ? -42.40564 -28.51416 -17.38851 1.000 30.79380 ? 27   ASP A CG  1 
ATOM   287  O OD1 . ASP A 1 38  ? -42.87431 -28.62749 -16.22810 1.000 27.74742 ? 27   ASP A OD1 1 
ATOM   288  O OD2 . ASP A 1 38  ? -43.01032 -27.93430 -18.31796 1.000 29.63194 ? 27   ASP A OD2 1 
ATOM   289  N N   . ALA A 1 39  ? -37.78104 -29.13183 -17.60306 1.000 16.39316 ? 28   ALA A N   1 
ATOM   290  C CA  . ALA A 1 39  ? -36.50745 -29.84302 -17.65270 1.000 14.41602 ? 28   ALA A CA  1 
ATOM   291  C C   . ALA A 1 39  ? -35.82709 -29.82258 -16.28750 1.000 16.36053 ? 28   ALA A C   1 
ATOM   292  O O   . ALA A 1 39  ? -35.19076 -30.80202 -15.88456 1.000 14.96873 ? 28   ALA A O   1 
ATOM   293  C CB  . ALA A 1 39  ? -35.61256 -29.24246 -18.74474 1.000 15.13536 ? 28   ALA A CB  1 
ATOM   294  N N   . CYS A 1 40  ? -35.97579 -28.73010 -15.53369 1.000 13.99366 ? 29   CYS A N   1 
ATOM   295  C CA  . CYS A 1 40  ? -35.40271 -28.73517 -14.18738 1.000 15.34774 ? 29   CYS A CA  1 
ATOM   296  C C   . CYS A 1 40  ? -36.07962 -29.77397 -13.30569 1.000 14.47257 ? 29   CYS A C   1 
ATOM   297  O O   . CYS A 1 40  ? -35.40180 -30.48696 -12.55421 1.000 14.88180 ? 29   CYS A O   1 
ATOM   298  C CB  . CYS A 1 40  ? -35.46696 -27.34106 -13.55267 1.000 13.29943 ? 29   CYS A CB  1 
ATOM   299  S SG  . CYS A 1 40  ? -34.35028 -26.09832 -14.37413 1.000 15.63217 ? 29   CYS A SG  1 
ATOM   300  N N   . ARG A 1 41  ? -37.40771 -29.89279 -13.40029 1.000 14.91092 ? 30   ARG A N   1 
ATOM   301  C CA  . ARG A 1 41  ? -38.10410 -30.95076 -12.66752 1.000 19.64551 ? 30   ARG A CA  1 
ATOM   302  C C   . ARG A 1 41  ? -37.56328 -32.32345 -13.04267 1.000 19.12559 ? 30   ARG A C   1 
ATOM   303  O O   . ARG A 1 41  ? -37.27130 -33.15124 -12.16670 1.000 15.88586 ? 30   ARG A O   1 
ATOM   304  C CB  . ARG A 1 41  ? -39.61590 -30.88272 -12.92676 1.000 20.76358 ? 30   ARG A CB  1 
ATOM   305  C CG  . ARG A 1 41  ? -40.39962 -32.06860 -12.33057 1.000 28.21391 ? 30   ARG A CG  1 
ATOM   306  C CD  . ARG A 1 41  ? -41.83156 -32.14277 -12.85451 1.000 32.20958 ? 30   ARG A CD  1 
ATOM   307  N NE  . ARG A 1 41  ? -41.94266 -32.20880 -14.31365 1.000 32.86454 ? 30   ARG A NE  1 
ATOM   308  C CZ  . ARG A 1 41  ? -41.63923 -33.27203 -15.05121 1.000 35.74001 ? 30   ARG A CZ  1 
ATOM   309  N NH1 . ARG A 1 41  ? -41.15501 -34.38028 -14.50876 1.000 38.01227 ? 30   ARG A NH1 1 
ATOM   310  N NH2 . ARG A 1 41  ? -41.85189 -33.23362 -16.36492 1.000 32.97639 ? 30   ARG A NH2 1 
ATOM   311  N N   . MET A 1 42  ? -37.41845 -32.60355 -14.34343 1.000 17.80432 ? 31   MET A N   1 
ATOM   312  C CA  . MET A 1 42  ? -36.90528 -33.93266 -14.65317 1.000 15.51903 ? 31   MET A CA  1 
ATOM   313  C C   . MET A 1 42  ? -35.46774 -34.11213 -14.19679 1.000 18.98174 ? 31   MET A C   1 
ATOM   314  O O   . MET A 1 42  ? -35.08282 -35.22997 -13.82210 1.000 19.56902 ? 31   MET A O   1 
ATOM   315  C CB  . MET A 1 42  ? -37.07728 -34.32565 -16.13458 1.000 23.60529 ? 31   MET A CB  1 
ATOM   316  C CG  . MET A 1 42  ? -38.28013 -33.77834 -16.89570 1.000 20.39778 ? 31   MET A CG  1 
ATOM   317  S SD  . MET A 1 42  ? -38.05107 -33.55383 -18.67815 1.000 20.71876 ? 31   MET A SD  1 
ATOM   318  C CE  . MET A 1 42  ? -37.57232 -35.23187 -19.12283 1.000 29.97613 ? 31   MET A CE  1 
ATOM   319  N N   . ILE A 1 43  ? -34.67560 -33.04094 -14.15443 1.000 14.52364 ? 32   ILE A N   1 
ATOM   320  C CA  . ILE A 1 43  ? -33.32482 -33.19156 -13.62474 1.000 13.54269 ? 32   ILE A CA  1 
ATOM   321  C C   . ILE A 1 43  ? -33.36841 -33.53276 -12.13577 1.000 17.68286 ? 32   ILE A C   1 
ATOM   322  O O   . ILE A 1 43  ? -32.62630 -34.40730 -11.66947 1.000 18.16450 ? 32   ILE A O   1 
ATOM   323  C CB  . ILE A 1 43  ? -32.47211 -31.93964 -13.91279 1.000 17.03678 ? 32   ILE A CB  1 
ATOM   324  C CG1 . ILE A 1 43  ? -32.12052 -31.87581 -15.40571 1.000 16.15226 ? 32   ILE A CG1 1 
ATOM   325  C CG2 . ILE A 1 43  ? -31.20778 -31.92593 -13.06381 1.000 13.93172 ? 32   ILE A CG2 1 
ATOM   326  C CD1 . ILE A 1 43  ? -31.81024 -30.46857 -15.89412 1.000 17.03884 ? 32   ILE A CD1 1 
ATOM   327  N N   . ARG A 1 44  ? -34.26103 -32.88697 -11.37587 1.000 17.51808 ? 33   ARG A N   1 
ATOM   328  C CA  . ARG A 1 44  ? -34.39631 -33.21810 -9.95346  1.000 15.30939 ? 33   ARG A CA  1 
ATOM   329  C C   . ARG A 1 44  ? -34.85964 -34.66135 -9.75002  1.000 21.36712 ? 33   ARG A C   1 
ATOM   330  O O   . ARG A 1 44  ? -34.54751 -35.27833 -8.71870  1.000 23.07540 ? 33   ARG A O   1 
ATOM   331  C CB  . ARG A 1 44  ? -35.37739 -32.26149 -9.27442  1.000 19.21345 ? 33   ARG A CB  1 
ATOM   332  C CG  . ARG A 1 44  ? -34.74916 -30.93023 -8.89524  1.000 19.51726 ? 33   ARG A CG  1 
ATOM   333  C CD  . ARG A 1 44  ? -35.76077 -29.93577 -8.31962  1.000 21.55073 ? 33   ARG A CD  1 
ATOM   334  N NE  . ARG A 1 44  ? -37.14205 -30.22130 -8.68565  1.000 20.47052 ? 33   ARG A NE  1 
ATOM   335  C CZ  . ARG A 1 44  ? -37.91704 -29.40037 -9.38163  1.000 22.70345 ? 33   ARG A CZ  1 
ATOM   336  N NH1 . ARG A 1 44  ? -37.42066 -28.33986 -9.99669  1.000 18.63107 ? 33   ARG A NH1 1 
ATOM   337  N NH2 . ARG A 1 44  ? -39.21769 -29.67573 -9.50011  1.000 27.28800 ? 33   ARG A NH2 1 
ATOM   338  N N   . GLU A 1 45  ? -35.61185 -35.21648 -10.70679 1.000 21.19877 ? 34   GLU A N   1 
ATOM   339  C CA  . GLU A 1 45  ? -36.02123 -36.61518 -10.60877 1.000 20.94777 ? 34   GLU A CA  1 
ATOM   340  C C   . GLU A 1 45  ? -34.91730 -37.61685 -10.94082 1.000 29.88786 ? 34   GLU A C   1 
ATOM   341  O O   . GLU A 1 45  ? -35.07831 -38.80045 -10.61970 1.000 26.50259 ? 34   GLU A O   1 
ATOM   342  C CB  . GLU A 1 45  ? -37.25042 -36.87053 -11.49153 1.000 22.60858 ? 34   GLU A CB  1 
ATOM   343  C CG  . GLU A 1 45  ? -38.44870 -36.02864 -11.09088 1.000 26.54947 ? 34   GLU A CG  1 
ATOM   344  C CD  . GLU A 1 45  ? -39.62421 -36.13072 -12.04758 1.000 31.03191 ? 34   GLU A CD  1 
ATOM   345  O OE1 . GLU A 1 45  ? -39.54206 -36.87569 -13.04491 1.000 35.70514 ? 34   GLU A OE1 1 
ATOM   346  O OE2 . GLU A 1 45  ? -40.64358 -35.46864 -11.78370 1.000 30.65864 ? 34   GLU A OE2 1 
ATOM   347  N N   . ARG A 1 46  ? -33.78579 -37.19245 -11.52243 1.000 20.19283 ? 35   ARG A N   1 
ATOM   348  C CA  . ARG A 1 46  ? -32.74771 -38.13217 -11.92720 1.000 24.80260 ? 35   ARG A CA  1 
ATOM   349  C C   . ARG A 1 46  ? -31.40342 -37.93726 -11.23393 1.000 24.54303 ? 35   ARG A C   1 
ATOM   350  O O   . ARG A 1 46  ? -30.67800 -38.91890 -11.04302 1.000 26.08582 ? 35   ARG A O   1 
ATOM   351  C CB  . ARG A 1 46  ? -32.55536 -38.06694 -13.46113 1.000 27.83490 ? 35   ARG A CB  1 
ATOM   352  C CG  . ARG A 1 46  ? -31.16805 -38.42964 -13.96811 1.000 28.10596 ? 35   ARG A CG  1 
ATOM   353  C CD  . ARG A 1 46  ? -31.09634 -39.88220 -14.42925 0.000 27.67811 ? 35   ARG A CD  1 
ATOM   354  N NE  . ARG A 1 46  ? -29.91328 -40.14884 -15.24088 0.000 28.71486 ? 35   ARG A NE  1 
ATOM   355  C CZ  . ARG A 1 46  ? -29.89933 -40.20303 -16.56578 0.000 28.52492 ? 35   ARG A CZ  1 
ATOM   356  N NH1 . ARG A 1 46  ? -30.99725 -40.01386 -17.27791 0.000 29.13727 ? 35   ARG A NH1 1 
ATOM   357  N NH2 . ARG A 1 46  ? -28.75396 -40.45654 -17.19229 0.000 28.78315 ? 35   ARG A NH2 1 
ATOM   358  N N   . ILE A 1 47  ? -31.04115 -36.71949 -10.85501 1.000 19.08177 ? 36   ILE A N   1 
ATOM   359  C CA  . ILE A 1 47  ? -29.72673 -36.42591 -10.29253 1.000 17.93593 ? 36   ILE A CA  1 
ATOM   360  C C   . ILE A 1 47  ? -29.91304 -35.99118 -8.84319  1.000 20.92593 ? 36   ILE A C   1 
ATOM   361  O O   . ILE A 1 47  ? -30.51159 -34.93543 -8.58563  1.000 19.42946 ? 36   ILE A O   1 
ATOM   362  C CB  . ILE A 1 47  ? -28.97356 -35.35343 -11.09483 1.000 15.10772 ? 36   ILE A CB  1 
ATOM   363  C CG1 . ILE A 1 47  ? -28.97797 -35.70095 -12.59096 1.000 19.76830 ? 36   ILE A CG1 1 
ATOM   364  C CG2 . ILE A 1 47  ? -27.56753 -35.20482 -10.59327 1.000 20.41024 ? 36   ILE A CG2 1 
ATOM   365  C CD1 . ILE A 1 47  ? -28.50324 -34.54984 -13.45910 1.000 21.20525 ? 36   ILE A CD1 1 
ATOM   366  N N   . PRO A 1 48  ? -29.40922 -36.75328 -7.87933  1.000 20.28540 ? 37   PRO A N   1 
ATOM   367  C CA  . PRO A 1 48  ? -29.63589 -36.39481 -6.47025  1.000 18.57660 ? 37   PRO A CA  1 
ATOM   368  C C   . PRO A 1 48  ? -29.02568 -35.06169 -6.08306  1.000 16.83321 ? 37   PRO A C   1 
ATOM   369  O O   . PRO A 1 48  ? -29.58949 -34.36221 -5.23188  1.000 16.49691 ? 37   PRO A O   1 
ATOM   370  C CB  . PRO A 1 48  ? -29.00096 -37.57059 -5.70429  1.000 22.85815 ? 37   PRO A CB  1 
ATOM   371  C CG  . PRO A 1 48  ? -28.09340 -38.24780 -6.70103  1.000 29.07950 ? 37   PRO A CG  1 
ATOM   372  C CD  . PRO A 1 48  ? -28.72721 -38.04945 -8.03709  1.000 23.51383 ? 37   PRO A CD  1 
ATOM   373  N N   . GLU A 1 49  ? -27.90351 -34.67324 -6.68831  1.000 15.94492 ? 38   GLU A N   1 
ATOM   374  C CA  . GLU A 1 49  ? -27.29572 -33.38080 -6.37375  1.000 18.52375 ? 38   GLU A CA  1 
ATOM   375  C C   . GLU A 1 49  ? -28.14061 -32.18566 -6.83207  1.000 16.92379 ? 38   GLU A C   1 
ATOM   376  O O   . GLU A 1 49  ? -27.83133 -31.05011 -6.45512  1.000 13.58892 ? 38   GLU A O   1 
ATOM   377  C CB  . GLU A 1 49  ? -25.89551 -33.30824 -6.99129  1.000 18.68273 ? 38   GLU A CB  1 
ATOM   378  C CG  . GLU A 1 49  ? -24.85483 -34.16278 -6.27062  1.000 26.63929 ? 38   GLU A CG  1 
ATOM   379  C CD  . GLU A 1 49  ? -24.84977 -35.61332 -6.73551  1.000 28.00000 ? 38   GLU A CD  1 
ATOM   380  O OE1 . GLU A 1 49  ? -25.53202 -35.92554 -7.73305  1.000 25.00268 ? 38   GLU A OE1 1 
ATOM   381  O OE2 . GLU A 1 49  ? -24.12091 -36.43109 -6.13177  1.000 30.40157 ? 38   GLU A OE2 1 
ATOM   382  N N   . ALA A 1 50  ? -29.18676 -32.41087 -7.63218  1.000 13.79655 ? 39   ALA A N   1 
ATOM   383  C CA  . ALA A 1 50  ? -30.13717 -31.37231 -8.00675  1.000 14.01656 ? 39   ALA A CA  1 
ATOM   384  C C   . ALA A 1 50  ? -31.07558 -31.00496 -6.86785  1.000 16.44591 ? 39   ALA A C   1 
ATOM   385  O O   . ALA A 1 50  ? -31.78524 -29.99896 -6.96641  1.000 15.76783 ? 39   ALA A O   1 
ATOM   386  C CB  . ALA A 1 50  ? -30.96956 -31.82031 -9.21421  1.000 16.73977 ? 39   ALA A CB  1 
ATOM   387  N N   . LEU A 1 51  ? -31.09983 -31.79748 -5.80106  1.000 14.41841 ? 40   LEU A N   1 
ATOM   388  C CA  . LEU A 1 51  ? -31.93937 -31.54108 -4.64119  1.000 13.89544 ? 40   LEU A CA  1 
ATOM   389  C C   . LEU A 1 51  ? -31.22053 -30.75710 -3.54345  1.000 13.42974 ? 40   LEU A C   1 
ATOM   390  O O   . LEU A 1 51  ? -31.70966 -30.71571 -2.39993  1.000 14.89843 ? 40   LEU A O   1 
ATOM   391  C CB  . LEU A 1 51  ? -32.46472 -32.86952 -4.07397  1.000 14.98622 ? 40   LEU A CB  1 
ATOM   392  C CG  . LEU A 1 51  ? -33.09343 -33.79093 -5.10282  1.000 20.57537 ? 40   LEU A CG  1 
ATOM   393  C CD1 . LEU A 1 51  ? -33.08416 -35.25775 -4.62794  1.000 22.24306 ? 40   LEU A CD1 1 
ATOM   394  C CD2 . LEU A 1 51  ? -34.48922 -33.29778 -5.40733  1.000 20.18590 ? 40   LEU A CD2 1 
ATOM   395  N N   . ALA A 1 52  ? -30.09123 -30.11549 -3.85516  1.000 12.77927 ? 41   ALA A N   1 
ATOM   396  C CA  . ALA A 1 52  ? -29.26949 -29.46833 -2.83334  1.000 14.63426 ? 41   ALA A CA  1 
ATOM   397  C C   . ALA A 1 52  ? -29.82659 -28.12579 -2.36249  1.000 15.53916 ? 41   ALA A C   1 
ATOM   398  O O   . ALA A 1 52  ? -29.05542 -27.29134 -1.86708  1.000 17.29811 ? 41   ALA A O   1 
ATOM   399  C CB  . ALA A 1 52  ? -27.83919 -29.27773 -3.33736  1.000 19.25105 ? 41   ALA A CB  1 
ATOM   400  N N   . GLY A 1 53  ? -31.12005 -27.89262 -2.50432  1.000 17.22878 ? 42   GLY A N   1 
ATOM   401  C CA  . GLY A 1 53  ? -31.71421 -26.65122 -2.06216  1.000 14.25636 ? 42   GLY A CA  1 
ATOM   402  C C   . GLY A 1 53  ? -33.14644 -26.55458 -2.53767  1.000 15.79991 ? 42   GLY A C   1 
ATOM   403  O O   . GLY A 1 53  ? -33.65741 -27.45044 -3.22462  1.000 14.40055 ? 42   GLY A O   1 
ATOM   404  N N   . PRO A 1 54  ? -33.83469 -25.47965 -2.16608  1.000 15.69970 ? 43   PRO A N   1 
ATOM   405  C CA  . PRO A 1 54  ? -35.20414 -25.26667 -2.66043  1.000 17.24917 ? 43   PRO A CA  1 
ATOM   406  C C   . PRO A 1 54  ? -35.21530 -25.27248 -4.17869  1.000 16.44060 ? 43   PRO A C   1 
ATOM   407  O O   . PRO A 1 54  ? -34.32325 -24.68666 -4.81233  1.000 13.90042 ? 43   PRO A O   1 
ATOM   408  C CB  . PRO A 1 54  ? -35.57235 -23.89039 -2.09765  1.000 19.97096 ? 43   PRO A CB  1 
ATOM   409  C CG  . PRO A 1 54  ? -34.68780 -23.74406 -0.86505  1.000 19.85399 ? 43   PRO A CG  1 
ATOM   410  C CD  . PRO A 1 54  ? -33.39556 -24.41213 -1.24510  1.000 18.78620 ? 43   PRO A CD  1 
ATOM   411  N N   . PRO A 1 55  ? -36.17206 -25.97507 -4.79490  1.000 16.09477 ? 44   PRO A N   1 
ATOM   412  C CA  . PRO A 1 55  ? -36.08272 -26.20576 -6.25125  1.000 17.82235 ? 44   PRO A CA  1 
ATOM   413  C C   . PRO A 1 55  ? -36.07996 -24.93907 -7.09137  1.000 16.20194 ? 44   PRO A C   1 
ATOM   414  O O   . PRO A 1 55  ? -35.39506 -24.89976 -8.12294  1.000 16.46078 ? 44   PRO A O   1 
ATOM   415  C CB  . PRO A 1 55  ? -37.31347 -27.08408 -6.54203  1.000 17.28931 ? 44   PRO A CB  1 
ATOM   416  C CG  . PRO A 1 55  ? -38.18316 -26.97621 -5.31473  1.000 19.72568 ? 44   PRO A CG  1 
ATOM   417  C CD  . PRO A 1 55  ? -37.24561 -26.77528 -4.17729  1.000 15.57176 ? 44   PRO A CD  1 
ATOM   418  N N   . ASN A 1 56  ? -36.82002 -23.90576 -6.69238  1.000 16.27775 ? 45   ASN A N   1 
ATOM   419  C CA  . ASN A 1 56  ? -36.84489 -22.67639 -7.48209  1.000 17.13348 ? 45   ASN A CA  1 
ATOM   420  C C   . ASN A 1 56  ? -35.57161 -21.85159 -7.33152  1.000 15.56651 ? 45   ASN A C   1 
ATOM   421  O O   . ASN A 1 56  ? -35.47773 -20.79799 -7.96914  1.000 18.04051 ? 45   ASN A O   1 
ATOM   422  C CB  . ASN A 1 56  ? -38.03788 -21.80165 -7.10273  1.000 18.71203 ? 45   ASN A CB  1 
ATOM   423  C CG  . ASN A 1 56  ? -38.45714 -20.86560 -8.23564  1.000 31.75746 ? 45   ASN A CG  1 
ATOM   424  O OD1 . ASN A 1 56  ? -38.39526 -21.22307 -9.42158  1.000 30.99398 ? 45   ASN A OD1 1 
ATOM   425  N ND2 . ASN A 1 56  ? -38.78445 -19.62446 -7.87822  1.000 30.45433 ? 45   ASN A ND2 1 
ATOM   426  N N   . ASP A 1 57  ? -34.60699 -22.28304 -6.50659  1.000 15.42808 ? 46   ASP A N   1 
ATOM   427  C CA  . ASP A 1 57  ? -33.30774 -21.61334 -6.40935  1.000 14.62049 ? 46   ASP A CA  1 
ATOM   428  C C   . ASP A 1 57  ? -32.36254 -21.95889 -7.55350  1.000 12.32335 ? 46   ASP A C   1 
ATOM   429  O O   . ASP A 1 57  ? -31.32467 -21.30345 -7.69020  1.000 13.79593 ? 46   ASP A O   1 
ATOM   430  C CB  . ASP A 1 57  ? -32.61349 -21.98156 -5.09051  1.000 14.69370 ? 46   ASP A CB  1 
ATOM   431  C CG  . ASP A 1 57  ? -33.20570 -21.25810 -3.89351  1.000 18.96687 ? 46   ASP A CG  1 
ATOM   432  O OD1 . ASP A 1 57  ? -34.20469 -20.53863 -4.05838  1.000 21.71599 ? 46   ASP A OD1 1 
ATOM   433  O OD2 . ASP A 1 57  ? -32.69537 -21.46435 -2.78214  1.000 20.00571 ? 46   ASP A OD2 1 
ATOM   434  N N   . PHE A 1 58  ? -32.68590 -22.95995 -8.37243  1.000 14.21267 ? 47   PHE A N   1 
ATOM   435  C CA  . PHE A 1 58  ? -31.80845 -23.43422 -9.42854  1.000 12.58603 ? 47   PHE A CA  1 
ATOM   436  C C   . PHE A 1 58  ? -32.41461 -23.17433 -10.80136 1.000 12.99718 ? 47   PHE A C   1 
ATOM   437  O O   . PHE A 1 58  ? -33.63953 -23.15694 -10.96692 1.000 13.47870 ? 47   PHE A O   1 
ATOM   438  C CB  . PHE A 1 58  ? -31.54782 -24.95298 -9.29267  1.000 13.85673 ? 47   PHE A CB  1 
ATOM   439  C CG  . PHE A 1 58  ? -30.90995 -25.33066 -8.00645  1.000 12.01158 ? 47   PHE A CG  1 
ATOM   440  C CD1 . PHE A 1 58  ? -29.53376 -25.28733 -7.87261  1.000 16.01659 ? 47   PHE A CD1 1 
ATOM   441  C CD2 . PHE A 1 58  ? -31.68492 -25.70695 -6.91712  1.000 16.59112 ? 47   PHE A CD2 1 
ATOM   442  C CE1 . PHE A 1 58  ? -28.92933 -25.62397 -6.68339  1.000 19.35353 ? 47   PHE A CE1 1 
ATOM   443  C CE2 . PHE A 1 58  ? -31.08226 -26.05589 -5.72699  1.000 19.98335 ? 47   PHE A CE2 1 
ATOM   444  C CZ  . PHE A 1 58  ? -29.70152 -26.00353 -5.60792  1.000 21.10028 ? 47   PHE A CZ  1 
ATOM   445  N N   . GLY A 1 59  ? -31.53293 -23.01326 -11.78939 1.000 14.20810 ? 48   GLY A N   1 
ATOM   446  C CA  . GLY A 1 59  ? -31.93684 -22.92415 -13.18451 1.000 11.74662 ? 48   GLY A CA  1 
ATOM   447  C C   . GLY A 1 59  ? -30.90890 -23.55413 -14.11201 1.000 12.81879 ? 48   GLY A C   1 
ATOM   448  O O   . GLY A 1 59  ? -29.97884 -24.21771 -13.64394 1.000 12.01408 ? 48   GLY A O   1 
ATOM   449  N N   . LEU A 1 60  ? -31.03772 -23.33402 -15.42216 1.000 11.45910 ? 49   LEU A N   1 
ATOM   450  C CA  . LEU A 1 60  ? -30.16081 -23.94230 -16.41013 1.000 13.13130 ? 49   LEU A CA  1 
ATOM   451  C C   . LEU A 1 60  ? -29.31786 -22.84888 -17.05748 1.000 11.64403 ? 49   LEU A C   1 
ATOM   452  O O   . LEU A 1 60  ? -29.83535 -21.77344 -17.37912 1.000 12.83207 ? 49   LEU A O   1 
ATOM   453  C CB  . LEU A 1 60  ? -30.96654 -24.70487 -17.46429 1.000 13.06414 ? 49   LEU A CB  1 
ATOM   454  C CG  . LEU A 1 60  ? -31.57723 -26.01734 -16.92983 1.000 16.76476 ? 49   LEU A CG  1 
ATOM   455  C CD1 . LEU A 1 60  ? -32.38218 -26.67427 -18.01170 1.000 17.63675 ? 49   LEU A CD1 1 
ATOM   456  C CD2 . LEU A 1 60  ? -30.48709 -26.95855 -16.42097 1.000 16.84060 ? 49   LEU A CD2 1 
ATOM   457  N N   . PHE A 1 61  ? -28.01578 -23.12119 -17.18181 1.000 12.45036 ? 50   PHE A N   1 
ATOM   458  C CA  . PHE A 1 61  ? -27.01246 -22.20990 -17.70964 1.000 15.65544 ? 50   PHE A CA  1 
ATOM   459  C C   . PHE A 1 61  ? -26.22465 -22.91736 -18.80623 1.000 17.58646 ? 50   PHE A C   1 
ATOM   460  O O   . PHE A 1 61  ? -25.69950 -24.01481 -18.59718 1.000 14.27935 ? 50   PHE A O   1 
ATOM   461  C CB  . PHE A 1 61  ? -26.06122 -21.75220 -16.59546 1.000 14.41873 ? 50   PHE A CB  1 
ATOM   462  C CG  . PHE A 1 61  ? -25.04958 -20.73938 -17.04031 1.000 16.04802 ? 50   PHE A CG  1 
ATOM   463  C CD1 . PHE A 1 61  ? -25.36267 -19.38492 -17.02375 1.000 14.80415 ? 50   PHE A CD1 1 
ATOM   464  C CD2 . PHE A 1 61  ? -23.77971 -21.13620 -17.44556 1.000 15.29605 ? 50   PHE A CD2 1 
ATOM   465  C CE1 . PHE A 1 61  ? -24.42751 -18.43591 -17.42324 1.000 13.47581 ? 50   PHE A CE1 1 
ATOM   466  C CE2 . PHE A 1 61  ? -22.84514 -20.19670 -17.85968 1.000 21.24946 ? 50   PHE A CE2 1 
ATOM   467  C CZ  . PHE A 1 61  ? -23.16941 -18.84320 -17.84457 1.000 14.84735 ? 50   PHE A CZ  1 
ATOM   468  N N   . LEU A 1 62  ? -26.11607 -22.27392 -19.96085 1.000 16.81659 ? 51   LEU A N   1 
ATOM   469  C CA  . LEU A 1 62  ? -25.40664 -22.81706 -21.10657 1.000 14.19092 ? 51   LEU A CA  1 
ATOM   470  C C   . LEU A 1 62  ? -23.99700 -22.24166 -21.09238 1.000 18.73578 ? 51   LEU A C   1 
ATOM   471  O O   . LEU A 1 62  ? -23.80828 -21.05200 -21.35578 1.000 18.45464 ? 51   LEU A O   1 
ATOM   472  C CB  . LEU A 1 62  ? -26.15998 -22.44864 -22.38339 1.000 17.29252 ? 51   LEU A CB  1 
ATOM   473  C CG  . LEU A 1 62  ? -25.85573 -23.15103 -23.69436 1.000 30.06095 ? 51   LEU A CG  1 
ATOM   474  C CD1 . LEU A 1 62  ? -25.96294 -24.67683 -23.51768 1.000 28.93919 ? 51   LEU A CD1 1 
ATOM   475  C CD2 . LEU A 1 62  ? -26.83125 -22.62820 -24.74597 1.000 26.56045 ? 51   LEU A CD2 1 
ATOM   476  N N   . SER A 1 63  ? -23.00315 -23.07105 -20.77397 1.000 19.72011 ? 52   SER A N   1 
ATOM   477  C CA  . SER A 1 63  ? -21.65302 -22.53265 -20.70827 1.000 22.67012 ? 52   SER A CA  1 
ATOM   478  C C   . SER A 1 63  ? -21.02910 -22.44847 -22.10030 1.000 24.11560 ? 52   SER A C   1 
ATOM   479  O O   . SER A 1 63  ? -21.56113 -22.95552 -23.09498 1.000 23.40603 ? 52   SER A O   1 
ATOM   480  C CB  . SER A 1 63  ? -20.76828 -23.37483 -19.79829 1.000 29.28101 ? 52   SER A CB  1 
ATOM   481  O OG  . SER A 1 63  ? -20.95677 -24.74623 -20.06401 1.000 36.92433 ? 52   SER A OG  1 
ATOM   482  N N   . ASP A 1 64  ? -19.87643 -21.79012 -22.15765 1.000 21.97678 ? 53   ASP A N   1 
ATOM   483  C CA  . ASP A 1 64  ? -19.14556 -21.61019 -23.40245 1.000 23.45200 ? 53   ASP A CA  1 
ATOM   484  C C   . ASP A 1 64  ? -17.66171 -21.53927 -23.06501 1.000 25.39051 ? 53   ASP A C   1 
ATOM   485  O O   . ASP A 1 64  ? -17.28192 -21.04638 -21.99857 1.000 20.73709 ? 53   ASP A O   1 
ATOM   486  C CB  . ASP A 1 64  ? -19.58249 -20.33090 -24.12878 1.000 24.11465 ? 53   ASP A CB  1 
ATOM   487  C CG  . ASP A 1 64  ? -19.12028 -20.29290 -25.57947 1.000 29.52268 ? 53   ASP A CG  1 
ATOM   488  O OD1 . ASP A 1 64  ? -18.00767 -19.80702 -25.84551 1.000 24.97642 ? 53   ASP A OD1 1 
ATOM   489  O OD2 . ASP A 1 64  ? -19.90531 -20.69778 -26.46035 1.000 30.52844 ? 53   ASP A OD2 1 
ATOM   490  N N   . ASP A 1 65  ? -16.81833 -22.02577 -23.98244 1.000 26.44883 ? 54   ASP A N   1 
ATOM   491  C CA  . ASP A 1 65  ? -15.37470 -21.90649 -23.77288 1.000 29.08332 ? 54   ASP A CA  1 
ATOM   492  C C   . ASP A 1 65  ? -14.96668 -20.45707 -23.56463 1.000 24.26865 ? 54   ASP A C   1 
ATOM   493  O O   . ASP A 1 65  ? -13.98200 -20.17932 -22.87171 1.000 29.28289 ? 54   ASP A O   1 
ATOM   494  C CB  . ASP A 1 65  ? -14.60121 -22.47916 -24.95867 1.000 28.83722 ? 54   ASP A CB  1 
ATOM   495  C CG  . ASP A 1 65  ? -14.83881 -23.95196 -25.14679 1.000 33.73223 ? 54   ASP A CG  1 
ATOM   496  O OD1 . ASP A 1 65  ? -15.22074 -24.62278 -24.16571 1.000 45.63734 ? 54   ASP A OD1 1 
ATOM   497  O OD2 . ASP A 1 65  ? -14.63979 -24.43658 -26.27842 1.000 45.29418 ? 54   ASP A OD2 1 
ATOM   498  N N   . ASP A 1 66  ? -15.69645 -19.52958 -24.16793 1.000 22.72576 ? 55   ASP A N   1 
ATOM   499  C CA  . ASP A 1 66  ? -15.52978 -18.11846 -23.87540 1.000 23.92255 ? 55   ASP A CA  1 
ATOM   500  C C   . ASP A 1 66  ? -16.56038 -17.73499 -22.82931 1.000 18.10287 ? 55   ASP A C   1 
ATOM   501  O O   . ASP A 1 66  ? -17.75774 -17.66801 -23.15067 1.000 17.09131 ? 55   ASP A O   1 
ATOM   502  C CB  . ASP A 1 66  ? -15.69314 -17.27973 -25.14269 1.000 24.82305 ? 55   ASP A CB  1 
ATOM   503  C CG  . ASP A 1 66  ? -15.63272 -15.78032 -24.87354 1.000 26.56269 ? 55   ASP A CG  1 
ATOM   504  O OD1 . ASP A 1 66  ? -15.29653 -15.37043 -23.74699 1.000 20.31865 ? 55   ASP A OD1 1 
ATOM   505  O OD2 . ASP A 1 66  ? -15.85811 -15.00679 -25.82319 1.000 30.09217 ? 55   ASP A OD2 1 
ATOM   506  N N   . PRO A 1 67  ? -16.15772 -17.50257 -21.57422 1.000 18.49838 ? 56   PRO A N   1 
ATOM   507  C CA  . PRO A 1 67  ? -17.15262 -17.23139 -20.52557 1.000 15.51703 ? 56   PRO A CA  1 
ATOM   508  C C   . PRO A 1 67  ? -18.06145 -16.06497 -20.84769 1.000 16.27537 ? 56   PRO A C   1 
ATOM   509  O O   . PRO A 1 67  ? -19.20130 -16.05323 -20.37237 1.000 15.84034 ? 56   PRO A O   1 
ATOM   510  C CB  . PRO A 1 67  ? -16.28982 -16.95543 -19.28115 1.000 17.94543 ? 56   PRO A CB  1 
ATOM   511  C CG  . PRO A 1 67  ? -15.01326 -17.68236 -19.54500 1.000 22.55089 ? 56   PRO A CG  1 
ATOM   512  C CD  . PRO A 1 67  ? -14.78775 -17.55918 -21.03699 1.000 20.23356 ? 56   PRO A CD  1 
ATOM   513  N N   . LYS A 1 68  ? -17.60756 -15.09064 -21.64507 1.000 18.27786 ? 57   LYS A N   1 
ATOM   514  C CA  . LYS A 1 68  ? -18.47829 -13.96685 -21.98406 1.000 18.86158 ? 57   LYS A CA  1 
ATOM   515  C C   . LYS A 1 68  ? -19.71236 -14.38859 -22.76940 1.000 16.86745 ? 57   LYS A C   1 
ATOM   516  O O   . LYS A 1 68  ? -20.68223 -13.62619 -22.80617 1.000 15.72297 ? 57   LYS A O   1 
ATOM   517  C CB  . LYS A 1 68  ? -17.70636 -12.89092 -22.75910 1.000 20.42956 ? 57   LYS A CB  1 
ATOM   518  C CG  . LYS A 1 68  ? -16.31599 -12.65633 -22.19724 1.000 22.75719 ? 57   LYS A CG  1 
ATOM   519  C CD  . LYS A 1 68  ? -15.79912 -11.27285 -22.51092 1.000 28.63914 ? 57   LYS A CD  1 
ATOM   520  C CE  . LYS A 1 68  ? -15.80750 -11.02264 -23.98234 1.000 31.36006 ? 57   LYS A CE  1 
ATOM   521  N NZ  . LYS A 1 68  ? -15.14919 -12.17801 -24.66539 1.000 37.45249 ? 57   LYS A NZ  1 
ATOM   522  N N   . LYS A 1 69  ? -19.71691 -15.58193 -23.37284 1.000 15.91691 ? 58   LYS A N   1 
ATOM   523  C CA  . LYS A 1 69  ? -20.85568 -16.05164 -24.15048 1.000 20.56444 ? 58   LYS A CA  1 
ATOM   524  C C   . LYS A 1 69  ? -21.77003 -17.01181 -23.39281 1.000 19.02869 ? 58   LYS A C   1 
ATOM   525  O O   . LYS A 1 69  ? -22.73762 -17.50827 -23.98242 1.000 18.17699 ? 58   LYS A O   1 
ATOM   526  C CB  . LYS A 1 69  ? -20.36156 -16.71672 -25.44058 1.000 20.19771 ? 58   LYS A CB  1 
ATOM   527  C CG  . LYS A 1 69  ? -19.51611 -15.77569 -26.29497 1.000 22.74629 ? 58   LYS A CG  1 
ATOM   528  C CD  . LYS A 1 69  ? -19.07982 -16.43306 -27.60093 1.000 30.06703 ? 58   LYS A CD  1 
ATOM   529  C CE  . LYS A 1 69  ? -20.26012 -16.96101 -28.39881 1.000 38.43742 ? 58   LYS A CE  1 
ATOM   530  N NZ  . LYS A 1 69  ? -19.84342 -17.45022 -29.75910 1.000 46.48041 ? 58   LYS A NZ  1 
ATOM   531  N N   . GLY A 1 70  ? -21.49403 -17.30363 -22.12407 1.000 16.25175 ? 59   GLY A N   1 
ATOM   532  C CA  . GLY A 1 70  ? -22.40903 -18.15325 -21.36132 1.000 13.57217 ? 59   GLY A CA  1 
ATOM   533  C C   . GLY A 1 70  ? -23.72998 -17.43430 -21.13186 1.000 14.13257 ? 59   GLY A C   1 
ATOM   534  O O   . GLY A 1 70  ? -23.77386 -16.21116 -20.97932 1.000 14.59371 ? 59   GLY A O   1 
ATOM   535  N N   . ILE A 1 71  ? -24.82955 -18.18464 -21.15561 1.000 13.61688 ? 60   ILE A N   1 
ATOM   536  C CA  . ILE A 1 71  ? -26.13689 -17.55636 -20.96244 1.000 12.94728 ? 60   ILE A CA  1 
ATOM   537  C C   . ILE A 1 71  ? -27.02650 -18.39233 -20.04841 1.000 13.91446 ? 60   ILE A C   1 
ATOM   538  O O   . ILE A 1 71  ? -27.01695 -19.62577 -20.08945 1.000 15.33918 ? 60   ILE A O   1 
ATOM   539  C CB  . ILE A 1 71  ? -26.85981 -17.27491 -22.29869 1.000 17.50673 ? 60   ILE A CB  1 
ATOM   540  C CG1 . ILE A 1 71  ? -27.14628 -18.56742 -23.06641 1.000 19.44851 ? 60   ILE A CG1 1 
ATOM   541  C CG2 . ILE A 1 71  ? -26.08311 -16.29457 -23.16049 1.000 21.52376 ? 60   ILE A CG2 1 
ATOM   542  C CD1 . ILE A 1 71  ? -28.38765 -18.44296 -23.92797 1.000 25.91088 ? 60   ILE A CD1 1 
ATOM   543  N N   . TRP A 1 72  ? -27.81940 -17.69700 -19.24181 1.000 12.69153 ? 61   TRP A N   1 
ATOM   544  C CA  . TRP A 1 72  ? -28.88280 -18.32211 -18.46796 1.000 13.07001 ? 61   TRP A CA  1 
ATOM   545  C C   . TRP A 1 72  ? -30.08675 -18.54733 -19.36987 1.000 14.64323 ? 61   TRP A C   1 
ATOM   546  O O   . TRP A 1 72  ? -30.43361 -17.69333 -20.18954 1.000 15.39223 ? 61   TRP A O   1 
ATOM   547  C CB  . TRP A 1 72  ? -29.29179 -17.41754 -17.30650 1.000 12.58765 ? 61   TRP A CB  1 
ATOM   548  C CG  . TRP A 1 72  ? -28.39727 -17.53300 -16.13299 1.000 13.22400 ? 61   TRP A CG  1 
ATOM   549  C CD1 . TRP A 1 72  ? -27.33051 -16.74075 -15.84183 1.000 11.98613 ? 61   TRP A CD1 1 
ATOM   550  C CD2 . TRP A 1 72  ? -28.49459 -18.49630 -15.08545 1.000 10.70340 ? 61   TRP A CD2 1 
ATOM   551  N NE1 . TRP A 1 72  ? -26.74841 -17.15337 -14.66603 1.000 12.71166 ? 61   TRP A NE1 1 
ATOM   552  C CE2 . TRP A 1 72  ? -27.45238 -18.22343 -14.17462 1.000 14.00650 ? 61   TRP A CE2 1 
ATOM   553  C CE3 . TRP A 1 72  ? -29.38431 -19.55243 -14.81409 1.000 16.27981 ? 61   TRP A CE3 1 
ATOM   554  C CZ2 . TRP A 1 72  ? -27.25302 -18.97303 -13.01190 1.000 13.83037 ? 61   TRP A CZ2 1 
ATOM   555  C CZ3 . TRP A 1 72  ? -29.18660 -20.30145 -13.64657 1.000 16.45903 ? 61   TRP A CZ3 1 
ATOM   556  C CH2 . TRP A 1 72  ? -28.12311 -20.00959 -12.76972 1.000 15.03621 ? 61   TRP A CH2 1 
ATOM   557  N N   . LEU A 1 73  ? -30.71964 -19.69669 -19.22062 1.000 11.84907 ? 62   LEU A N   1 
ATOM   558  C CA  . LEU A 1 73  ? -31.93723 -19.99448 -19.94862 1.000 13.26740 ? 62   LEU A CA  1 
ATOM   559  C C   . LEU A 1 73  ? -33.14758 -19.47719 -19.17861 1.000 18.83241 ? 62   LEU A C   1 
ATOM   560  O O   . LEU A 1 73  ? -33.17793 -19.52860 -17.94344 1.000 17.41264 ? 62   LEU A O   1 
ATOM   561  C CB  . LEU A 1 73  ? -32.05031 -21.50396 -20.17026 1.000 13.05226 ? 62   LEU A CB  1 
ATOM   562  C CG  . LEU A 1 73  ? -30.86196 -22.19968 -20.84392 1.000 15.97624 ? 62   LEU A CG  1 
ATOM   563  C CD1 . LEU A 1 73  ? -31.29326 -23.58650 -21.31721 1.000 19.24234 ? 62   LEU A CD1 1 
ATOM   564  C CD2 . LEU A 1 73  ? -30.31344 -21.41419 -22.00624 1.000 17.78214 ? 62   LEU A CD2 1 
ATOM   565  N N   . GLU A 1 74  ? -34.15737 -18.99088 -19.90758 1.000 16.30784 ? 63   GLU A N   1 
ATOM   566  C CA  . GLU A 1 74  ? -35.38931 -18.56295 -19.25127 1.000 16.01519 ? 63   GLU A CA  1 
ATOM   567  C C   . GLU A 1 74  ? -36.34689 -19.72888 -19.04094 1.000 16.72215 ? 63   GLU A C   1 
ATOM   568  O O   . GLU A 1 74  ? -36.49532 -20.59912 -19.90361 1.000 16.24337 ? 63   GLU A O   1 
ATOM   569  C CB  . GLU A 1 74  ? -36.09779 -17.44709 -20.02948 1.000 22.53414 ? 63   GLU A CB  1 
ATOM   570  C CG  . GLU A 1 74  ? -35.20843 -16.26885 -20.43071 1.000 23.22991 ? 63   GLU A CG  1 
ATOM   571  C CD  . GLU A 1 74  ? -35.89176 -15.37289 -21.45877 1.000 35.85928 ? 63   GLU A CD  1 
ATOM   572  O OE1 . GLU A 1 74  ? -35.19309 -14.61060 -22.15551 1.000 39.22916 ? 63   GLU A OE1 1 
ATOM   573  O OE2 . GLU A 1 74  ? -37.14034 -15.40025 -21.53927 1.000 37.04081 ? 63   GLU A OE2 1 
ATOM   574  N N   . ALA A 1 75  ? -37.03601 -19.69807 -17.88952 1.000 17.98738 ? 64   ALA A N   1 
ATOM   575  C CA  . ALA A 1 75  ? -37.84180 -20.82413 -17.42050 1.000 18.46413 ? 64   ALA A CA  1 
ATOM   576  C C   . ALA A 1 75  ? -38.99040 -21.15261 -18.36467 1.000 18.11840 ? 64   ALA A C   1 
ATOM   577  O O   . ALA A 1 75  ? -39.37432 -22.32172 -18.49426 1.000 16.65236 ? 64   ALA A O   1 
ATOM   578  C CB  . ALA A 1 75  ? -38.41042 -20.51448 -16.03631 1.000 19.73835 ? 64   ALA A CB  1 
ATOM   579  N N   . GLY A 1 76  ? -39.57631 -20.13502 -18.99348 1.000 18.37991 ? 65   GLY A N   1 
ATOM   580  C CA  . GLY A 1 76  ? -40.72055 -20.28222 -19.86092 1.000 19.62899 ? 65   GLY A CA  1 
ATOM   581  C C   . GLY A 1 76  ? -40.42752 -20.66684 -21.29186 1.000 22.24187 ? 65   GLY A C   1 
ATOM   582  O O   . GLY A 1 76  ? -41.37395 -20.86426 -22.06068 1.000 25.46405 ? 65   GLY A O   1 
ATOM   583  N N   . LYS A 1 77  ? -39.15662 -20.79395 -21.67285 1.000 15.46197 ? 66   LYS A N   1 
ATOM   584  C CA  . LYS A 1 77  ? -38.77061 -21.08069 -23.05050 1.000 17.36480 ? 66   LYS A CA  1 
ATOM   585  C C   . LYS A 1 77  ? -38.55763 -22.57413 -23.25253 1.000 16.79800 ? 66   LYS A C   1 
ATOM   586  O O   . LYS A 1 77  ? -38.17307 -23.29481 -22.33095 1.000 16.86826 ? 66   LYS A O   1 
ATOM   587  C CB  . LYS A 1 77  ? -37.47822 -20.34627 -23.43095 1.000 17.87942 ? 66   LYS A CB  1 
ATOM   588  C CG  . LYS A 1 77  ? -37.65107 -18.83665 -23.56029 1.000 22.32709 ? 66   LYS A CG  1 
ATOM   589  C CD  . LYS A 1 77  ? -38.42225 -18.48490 -24.80869 1.000 27.04732 ? 66   LYS A CD  1 
ATOM   590  C CE  . LYS A 1 77  ? -38.43189 -16.98293 -25.08707 1.000 33.15082 ? 66   LYS A CE  1 
ATOM   591  N NZ  . LYS A 1 77  ? -37.17789 -16.34413 -24.63437 1.000 38.17426 ? 66   LYS A NZ  1 
ATOM   592  N N   . ALA A 1 78  ? -38.78588 -23.02684 -24.48149 1.000 13.86562 ? 67   ALA A N   1 
ATOM   593  C CA  . ALA A 1 78  ? -38.52207 -24.41015 -24.84994 1.000 17.73560 ? 67   ALA A CA  1 
ATOM   594  C C   . ALA A 1 78  ? -37.02932 -24.61882 -25.06514 1.000 12.65445 ? 67   ALA A C   1 
ATOM   595  O O   . ALA A 1 78  ? -36.31563 -23.71689 -25.50744 1.000 14.34509 ? 67   ALA A O   1 
ATOM   596  C CB  . ALA A 1 78  ? -39.27891 -24.79198 -26.12950 1.000 18.80697 ? 67   ALA A CB  1 
ATOM   597  N N   . LEU A 1 79  ? -36.55798 -25.83089 -24.74582 1.000 14.28027 ? 68   LEU A N   1 
ATOM   598  C CA  . LEU A 1 79  ? -35.15586 -26.16406 -24.98564 1.000 13.73692 ? 68   LEU A CA  1 
ATOM   599  C C   . LEU A 1 79  ? -34.74464 -25.88788 -26.43041 1.000 15.45826 ? 68   LEU A C   1 
ATOM   600  O O   . LEU A 1 79  ? -33.65740 -25.34000 -26.68052 1.000 17.82101 ? 68   LEU A O   1 
ATOM   601  C CB  . LEU A 1 79  ? -34.90304 -27.63107 -24.63143 1.000 14.21190 ? 68   LEU A CB  1 
ATOM   602  C CG  . LEU A 1 79  ? -35.00031 -28.01087 -23.16169 1.000 15.02570 ? 68   LEU A CG  1 
ATOM   603  C CD1 . LEU A 1 79  ? -34.76688 -29.53076 -23.04232 1.000 15.60207 ? 68   LEU A CD1 1 
ATOM   604  C CD2 . LEU A 1 79  ? -33.97762 -27.22649 -22.34698 1.000 17.69906 ? 68   LEU A CD2 1 
ATOM   605  N N   . ASP A 1 80  ? -35.60281 -26.23030 -27.40642 1.000 16.23635 ? 69   ASP A N   1 
ATOM   606  C CA  . ASP A 1 80  ? -35.14293 -26.02289 -28.77643 1.000 17.27649 ? 69   ASP A CA  1 
ATOM   607  C C   . ASP A 1 80  ? -35.14517 -24.56485 -29.20810 1.000 14.26649 ? 69   ASP A C   1 
ATOM   608  O O   . ASP A 1 80  ? -34.55961 -24.25287 -30.25780 1.000 15.86836 ? 69   ASP A O   1 
ATOM   609  C CB  . ASP A 1 80  ? -35.93095 -26.85089 -29.80834 1.000 18.78991 ? 69   ASP A CB  1 
ATOM   610  C CG  . ASP A 1 80  ? -37.40323 -26.47180 -29.92577 1.000 23.39485 ? 69   ASP A CG  1 
ATOM   611  O OD1 . ASP A 1 80  ? -37.88940 -25.49667 -29.30767 1.000 20.77240 ? 69   ASP A OD1 1 
ATOM   612  O OD2 . ASP A 1 80  ? -38.07213 -27.12755 -30.76143 1.000 25.20370 ? 69   ASP A OD2 1 
ATOM   613  N N   . TYR A 1 81  ? -35.77943 -23.66794 -28.44508 1.000 16.76129 ? 70   TYR A N   1 
ATOM   614  C CA  . TYR A 1 81  ? -35.56114 -22.24202 -28.68578 1.000 14.90494 ? 70   TYR A CA  1 
ATOM   615  C C   . TYR A 1 81  ? -34.06535 -21.91213 -28.66976 1.000 13.54325 ? 70   TYR A C   1 
ATOM   616  O O   . TYR A 1 81  ? -33.59726 -21.08601 -29.45988 1.000 12.03892 ? 70   TYR A O   1 
ATOM   617  C CB  . TYR A 1 81  ? -36.30642 -21.40091 -27.63814 1.000 15.21260 ? 70   TYR A CB  1 
ATOM   618  C CG  . TYR A 1 81  ? -35.96567 -19.91902 -27.65485 1.000 15.34997 ? 70   TYR A CG  1 
ATOM   619  C CD1 . TYR A 1 81  ? -36.67721 -19.03382 -28.45273 1.000 16.21446 ? 70   TYR A CD1 1 
ATOM   620  C CD2 . TYR A 1 81  ? -34.89870 -19.41306 -26.89957 1.000 17.22316 ? 70   TYR A CD2 1 
ATOM   621  C CE1 . TYR A 1 81  ? -36.37290 -17.67928 -28.46733 1.000 19.21579 ? 70   TYR A CE1 1 
ATOM   622  C CE2 . TYR A 1 81  ? -34.58061 -18.06454 -26.92110 1.000 20.81802 ? 70   TYR A CE2 1 
ATOM   623  C CZ  . TYR A 1 81  ? -35.32570 -17.20163 -27.70959 1.000 19.73564 ? 70   TYR A CZ  1 
ATOM   624  O OH  . TYR A 1 81  ? -35.02633 -15.84977 -27.74595 1.000 21.77118 ? 70   TYR A OH  1 
ATOM   625  N N   . TYR A 1 82  ? -33.28863 -22.55862 -27.78264 1.000 14.47926 ? 71   TYR A N   1 
ATOM   626  C CA  . TYR A 1 82  ? -31.86432 -22.24147 -27.61860 1.000 16.38459 ? 71   TYR A CA  1 
ATOM   627  C C   . TYR A 1 82  ? -30.95471 -22.95168 -28.62634 1.000 16.15886 ? 71   TYR A C   1 
ATOM   628  O O   . TYR A 1 82  ? -29.72733 -22.89472 -28.47002 1.000 15.62340 ? 71   TYR A O   1 
ATOM   629  C CB  . TYR A 1 82  ? -31.41976 -22.54310 -26.16349 1.000 15.54363 ? 71   TYR A CB  1 
ATOM   630  C CG  . TYR A 1 82  ? -32.08418 -21.57935 -25.21802 1.000 13.67750 ? 71   TYR A CG  1 
ATOM   631  C CD1 . TYR A 1 82  ? -31.62817 -20.26179 -25.11239 1.000 15.87370 ? 71   TYR A CD1 1 
ATOM   632  C CD2 . TYR A 1 82  ? -33.22967 -21.93567 -24.51397 1.000 12.22219 ? 71   TYR A CD2 1 
ATOM   633  C CE1 . TYR A 1 82  ? -32.25963 -19.33462 -24.28678 1.000 14.76274 ? 71   TYR A CE1 1 
ATOM   634  C CE2 . TYR A 1 82  ? -33.87127 -21.01726 -23.69513 1.000 14.45060 ? 71   TYR A CE2 1 
ATOM   635  C CZ  . TYR A 1 82  ? -33.38118 -19.71692 -23.59159 1.000 16.83456 ? 71   TYR A CZ  1 
ATOM   636  O OH  . TYR A 1 82  ? -34.01538 -18.80009 -22.78339 1.000 16.73378 ? 71   TYR A OH  1 
ATOM   637  N N   . MET A 1 83  ? -31.52790 -23.56588 -29.66543 1.000 15.69847 ? 72   MET A N   1 
ATOM   638  C CA  . MET A 1 83  ? -30.77213 -24.22126 -30.74371 1.000 14.19391 ? 72   MET A CA  1 
ATOM   639  C C   . MET A 1 83  ? -29.72741 -25.19951 -30.21555 1.000 19.97669 ? 72   MET A C   1 
ATOM   640  O O   . MET A 1 83  ? -28.60632 -25.30306 -30.72997 1.000 17.36874 ? 72   MET A O   1 
ATOM   641  C CB  . MET A 1 83  ? -30.16548 -23.21237 -31.73862 1.000 19.51080 ? 72   MET A CB  1 
ATOM   642  C CG  . MET A 1 83  ? -30.99496 -21.92753 -32.00393 1.000 19.65679 ? 72   MET A CG  1 
ATOM   643  S SD  . MET A 1 83  ? -30.10455 -20.39043 -32.47381 1.000 21.22505 ? 72   MET A SD  1 
ATOM   644  C CE  . MET A 1 83  ? -29.72585 -20.92321 -34.13823 1.000 19.75423 ? 72   MET A CE  1 
ATOM   645  N N   . LEU A 1 84  ? -30.13353 -25.95732 -29.20125 1.000 12.08360 ? 73   LEU A N   1 
ATOM   646  C CA  . LEU A 1 84  ? -29.31459 -27.00878 -28.62549 1.000 14.79244 ? 73   LEU A CA  1 
ATOM   647  C C   . LEU A 1 84  ? -29.17963 -28.17833 -29.59631 1.000 19.08169 ? 73   LEU A C   1 
ATOM   648  O O   . LEU A 1 84  ? -30.07079 -28.45263 -30.41016 1.000 16.16293 ? 73   LEU A O   1 
ATOM   649  C CB  . LEU A 1 84  ? -29.93573 -27.49669 -27.31122 1.000 15.89989 ? 73   LEU A CB  1 
ATOM   650  C CG  . LEU A 1 84  ? -30.17871 -26.41219 -26.25515 1.000 20.41383 ? 73   LEU A CG  1 
ATOM   651  C CD1 . LEU A 1 84  ? -30.93385 -26.95709 -25.03949 1.000 15.40377 ? 73   LEU A CD1 1 
ATOM   652  C CD2 . LEU A 1 84  ? -28.85267 -25.81875 -25.81669 1.000 22.74688 ? 73   LEU A CD2 1 
ATOM   653  N N   . ARG A 1 85  ? -28.06090 -28.87936 -29.48037 1.000 16.99783 ? 74   ARG A N   1 
ATOM   654  C CA  . ARG A 1 85  ? -27.74538 -30.04802 -30.29260 1.000 19.63436 ? 74   ARG A CA  1 
ATOM   655  C C   . ARG A 1 85  ? -27.39170 -31.20888 -29.37032 1.000 19.55313 ? 74   ARG A C   1 
ATOM   656  O O   . ARG A 1 85  ? -26.90789 -30.99724 -28.25718 1.000 18.79817 ? 74   ARG A O   1 
ATOM   657  C CB  . ARG A 1 85  ? -26.53723 -29.77238 -31.21839 1.000 26.04097 ? 74   ARG A CB  1 
ATOM   658  C CG  . ARG A 1 85  ? -26.86828 -29.20153 -32.58102 1.000 33.61320 ? 74   ARG A CG  1 
ATOM   659  C CD  . ARG A 1 85  ? -25.89902 -28.08572 -32.94372 0.000 30.80386 ? 74   ARG A CD  1 
ATOM   660  N NE  . ARG A 1 85  ? -24.65281 -28.60659 -33.49466 0.000 33.61888 ? 74   ARG A NE  1 
ATOM   661  C CZ  . ARG A 1 85  ? -23.99130 -28.05965 -34.50559 0.000 34.94056 ? 74   ARG A CZ  1 
ATOM   662  N NH1 . ARG A 1 85  ? -24.43335 -26.97048 -35.11231 0.000 34.90476 ? 74   ARG A NH1 1 
ATOM   663  N NH2 . ARG A 1 85  ? -22.85770 -28.62013 -34.91854 0.000 36.08389 ? 74   ARG A NH2 1 
ATOM   664  N N   . ASN A 1 86  ? -27.60417 -32.43531 -29.85059 1.000 19.88111 ? 75   ASN A N   1 
ATOM   665  C CA  . ASN A 1 86  ? -27.19354 -33.62339 -29.09923 1.000 19.42534 ? 75   ASN A CA  1 
ATOM   666  C C   . ASN A 1 86  ? -25.73602 -33.49176 -28.67503 1.000 23.73760 ? 75   ASN A C   1 
ATOM   667  O O   . ASN A 1 86  ? -24.88906 -33.03943 -29.44945 1.000 24.11965 ? 75   ASN A O   1 
ATOM   668  C CB  . ASN A 1 86  ? -27.39049 -34.89498 -29.93736 1.000 17.72061 ? 75   ASN A CB  1 
ATOM   669  C CG  . ASN A 1 86  ? -28.84500 -35.20129 -30.19178 1.000 20.82366 ? 75   ASN A CG  1 
ATOM   670  O OD1 . ASN A 1 86  ? -29.69886 -34.95740 -29.33694 1.000 20.88800 ? 75   ASN A OD1 1 
ATOM   671  N ND2 . ASN A 1 86  ? -29.14571 -35.72033 -31.37153 1.000 21.22490 ? 75   ASN A ND2 1 
ATOM   672  N N   . GLY A 1 87  ? -25.45447 -33.84954 -27.41838 1.000 19.59488 ? 76   GLY A N   1 
ATOM   673  C CA  . GLY A 1 87  ? -24.11521 -33.74055 -26.87830 1.000 21.54185 ? 76   GLY A CA  1 
ATOM   674  C C   . GLY A 1 87  ? -23.79066 -32.43186 -26.19304 1.000 23.70731 ? 76   GLY A C   1 
ATOM   675  O O   . GLY A 1 87  ? -22.76752 -32.35641 -25.50155 1.000 23.48508 ? 76   GLY A O   1 
ATOM   676  N N   . ASP A 1 88  ? -24.60927 -31.39061 -26.37393 1.000 21.63534 ? 77   ASP A N   1 
ATOM   677  C CA  . ASP A 1 88  ? -24.41593 -30.14224 -25.64576 1.000 21.80014 ? 77   ASP A CA  1 
ATOM   678  C C   . ASP A 1 88  ? -24.58035 -30.36403 -24.14458 1.000 17.31118 ? 77   ASP A C   1 
ATOM   679  O O   . ASP A 1 88  ? -25.30399 -31.25922 -23.69897 1.000 22.10256 ? 77   ASP A O   1 
ATOM   680  C CB  . ASP A 1 88  ? -25.42587 -29.08531 -26.09869 1.000 23.65788 ? 77   ASP A CB  1 
ATOM   681  C CG  . ASP A 1 88  ? -25.07080 -28.45665 -27.43437 1.000 27.58478 ? 77   ASP A CG  1 
ATOM   682  O OD1 . ASP A 1 88  ? -24.00250 -28.77178 -28.00003 1.000 23.38802 ? 77   ASP A OD1 1 
ATOM   683  O OD2 . ASP A 1 88  ? -25.89068 -27.65755 -27.92652 1.000 23.74147 ? 77   ASP A OD2 1 
ATOM   684  N N   . THR A 1 89  ? -23.91336 -29.52050 -23.37346 1.000 16.74788 ? 78   THR A N   1 
ATOM   685  C CA  . THR A 1 89  ? -23.93230 -29.56110 -21.91434 1.000 22.20056 ? 78   THR A CA  1 
ATOM   686  C C   . THR A 1 89  ? -24.72442 -28.37569 -21.37475 1.000 23.91314 ? 78   THR A C   1 
ATOM   687  O O   . THR A 1 89  ? -24.57885 -27.24830 -21.86097 1.000 23.87101 ? 78   THR A O   1 
ATOM   688  C CB  . THR A 1 89  ? -22.49914 -29.51364 -21.35292 1.000 20.82703 ? 78   THR A CB  1 
ATOM   689  O OG1 . THR A 1 89  ? -21.78539 -30.68298 -21.77568 1.000 25.30191 ? 78   THR A OG1 1 
ATOM   690  C CG2 . THR A 1 89  ? -22.50609 -29.46883 -19.82565 1.000 23.55138 ? 78   THR A CG2 1 
ATOM   691  N N   . MET A 1 90  ? -25.57025 -28.61112 -20.37687 1.000 15.57715 ? 79   MET A N   1 
ATOM   692  C CA  . MET A 1 90  ? -26.13318 -27.49735 -19.63050 1.000 20.85591 ? 79   MET A CA  1 
ATOM   693  C C   . MET A 1 90  ? -25.85902 -27.67802 -18.14327 1.000 18.02856 ? 79   MET A C   1 
ATOM   694  O O   . MET A 1 90  ? -25.91536 -28.79235 -17.60649 1.000 16.98670 ? 79   MET A O   1 
ATOM   695  C CB  . MET A 1 90  ? -27.64161 -27.24018 -19.88812 1.000 23.86705 ? 79   MET A CB  1 
ATOM   696  C CG  . MET A 1 90  ? -28.32342 -27.79496 -21.16502 1.000 24.23058 ? 79   MET A CG  1 
ATOM   697  S SD  . MET A 1 90  ? -30.13752 -27.51180 -21.10502 1.000 23.44698 ? 79   MET A SD  1 
ATOM   698  C CE  . MET A 1 90  ? -30.77784 -29.06959 -20.50923 1.000 27.40041 ? 79   MET A CE  1 
ATOM   699  N N   . GLU A 1 91  ? -25.50585 -26.57551 -17.49885 1.000 18.01935 ? 80   GLU A N   1 
ATOM   700  C CA  . GLU A 1 91  ? -25.19069 -26.58956 -16.08249 1.000 16.34706 ? 80   GLU A CA  1 
ATOM   701  C C   . GLU A 1 91  ? -26.44503 -26.27632 -15.28718 1.000 15.93687 ? 80   GLU A C   1 
ATOM   702  O O   . GLU A 1 91  ? -27.15718 -25.31796 -15.58874 1.000 16.42820 ? 80   GLU A O   1 
ATOM   703  C CB  . GLU A 1 91  ? -24.07437 -25.60086 -15.76550 1.000 16.83747 ? 80   GLU A CB  1 
ATOM   704  C CG  . GLU A 1 91  ? -22.67306 -26.19249 -16.09064 1.000 27.26713 ? 80   GLU A CG  1 
ATOM   705  C CD  . GLU A 1 91  ? -21.61999 -25.15031 -16.41598 1.000 33.31912 ? 80   GLU A CD  1 
ATOM   706  O OE1 . GLU A 1 91  ? -21.63944 -24.08569 -15.76274 1.000 33.67752 ? 80   GLU A OE1 1 
ATOM   707  O OE2 . GLU A 1 91  ? -20.74093 -25.42069 -17.27331 1.000 36.86732 ? 80   GLU A OE2 1 
ATOM   708  N N   . TYR A 1 92  ? -26.72580 -27.11434 -14.29285 1.000 15.90091 ? 81   TYR A N   1 
ATOM   709  C CA  . TYR A 1 92  ? -27.79936 -26.88662 -13.33842 1.000 12.71432 ? 81   TYR A CA  1 
ATOM   710  C C   . TYR A 1 92  ? -27.19140 -26.07677 -12.19894 1.000 14.71067 ? 81   TYR A C   1 
ATOM   711  O O   . TYR A 1 92  ? -26.37070 -26.59241 -11.43542 1.000 17.05321 ? 81   TYR A O   1 
ATOM   712  C CB  . TYR A 1 92  ? -28.33810 -28.23302 -12.86415 1.000 15.36454 ? 81   TYR A CB  1 
ATOM   713  C CG  . TYR A 1 92  ? -29.48730 -28.21683 -11.89683 1.000 14.53447 ? 81   TYR A CG  1 
ATOM   714  C CD1 . TYR A 1 92  ? -30.80241 -28.19268 -12.33277 1.000 11.72422 ? 81   TYR A CD1 1 
ATOM   715  C CD2 . TYR A 1 92  ? -29.24561 -28.27983 -10.52843 1.000 11.30849 ? 81   TYR A CD2 1 
ATOM   716  C CE1 . TYR A 1 92  ? -31.85766 -28.21702 -11.41911 1.000 14.98342 ? 81   TYR A CE1 1 
ATOM   717  C CE2 . TYR A 1 92  ? -30.26751 -28.31072 -9.62629  1.000 15.68887 ? 81   TYR A CE2 1 
ATOM   718  C CZ  . TYR A 1 92  ? -31.56126 -28.27579 -10.05446 1.000 16.93789 ? 81   TYR A CZ  1 
ATOM   719  O OH  . TYR A 1 92  ? -32.54440 -28.31521 -9.10098  1.000 17.40600 ? 81   TYR A OH  1 
ATOM   720  N N   . ARG A 1 93  ? -27.56737 -24.80697 -12.10605 1.000 16.88275 ? 82   ARG A N   1 
ATOM   721  C CA  . ARG A 1 93  ? -26.80997 -23.81397 -11.36581 1.000 17.22579 ? 82   ARG A CA  1 
ATOM   722  C C   . ARG A 1 93  ? -27.73317 -23.02602 -10.45472 1.000 13.27938 ? 82   ARG A C   1 
ATOM   723  O O   . ARG A 1 93  ? -28.87997 -22.75146 -10.80439 1.000 13.16566 ? 82   ARG A O   1 
ATOM   724  C CB  . ARG A 1 93  ? -26.09833 -22.82078 -12.32279 1.000 13.64982 ? 82   ARG A CB  1 
ATOM   725  N N   . LYS A 1 94  ? -27.19734 -22.61299 -9.30409  1.000 12.71569 ? 83   LYS A N   1 
ATOM   726  C CA  . LYS A 1 94  ? -27.92891 -21.70617 -8.42326  1.000 11.91472 ? 83   LYS A CA  1 
ATOM   727  C C   . LYS A 1 94  ? -28.10036 -20.34066 -9.09938  1.000 14.60969 ? 83   LYS A C   1 
ATOM   728  O O   . LYS A 1 94  ? -27.14570 -19.78482 -9.65540  1.000 15.16709 ? 83   LYS A O   1 
ATOM   729  C CB  . LYS A 1 94  ? -27.18770 -21.58281 -7.08272  1.000 19.60574 ? 83   LYS A CB  1 
ATOM   730  C CG  . LYS A 1 94  ? -27.92420 -20.88108 -5.94192  1.000 26.48800 ? 83   LYS A CG  1 
ATOM   731  C CD  . LYS A 1 94  ? -27.06291 -20.90963 -4.64690  1.000 27.62684 ? 83   LYS A CD  1 
ATOM   732  C CE  . LYS A 1 94  ? -27.65851 -20.13091 -3.45351  1.000 28.27701 ? 83   LYS A CE  1 
ATOM   733  N NZ  . LYS A 1 94  ? -29.02541 -19.53524 -3.67627  1.000 30.92804 ? 83   LYS A NZ  1 
ATOM   734  N N   . LYS A 1 95  ? -29.33583 -19.81883 -9.08586  1.000 13.32210 ? 84   LYS A N   1 
ATOM   735  C CA  . LYS A 1 95  ? -29.62848 -18.58267 -9.80927  1.000 13.22446 ? 84   LYS A CA  1 
ATOM   736  C C   . LYS A 1 95  ? -28.94358 -17.38400 -9.18486  1.000 14.71527 ? 84   LYS A C   1 
ATOM   737  O O   . LYS A 1 95  ? -28.62128 -16.41902 -9.88998  1.000 15.22468 ? 84   LYS A O   1 
ATOM   738  C CB  . LYS A 1 95  ? -31.13796 -18.30854 -9.87280  1.000 14.48436 ? 84   LYS A CB  1 
ATOM   739  C CG  . LYS A 1 95  ? -31.97655 -19.32216 -10.68644 1.000 17.60927 ? 84   LYS A CG  1 
ATOM   740  C CD  . LYS A 1 95  ? -33.37022 -19.46654 -10.04536 1.000 23.07586 ? 84   LYS A CD  1 
ATOM   741  C CE  . LYS A 1 95  ? -34.43763 -19.91594 -11.02798 1.000 25.36777 ? 84   LYS A CE  1 
ATOM   742  N NZ  . LYS A 1 95  ? -35.81755 -19.68453 -10.50303 1.000 21.93063 ? 84   LYS A NZ  1 
ATOM   743  N N   . GLN A 1 96  ? -28.75989 -17.39839 -7.87303  1.000 14.79542 ? 85   GLN A N   1 
ATOM   744  C CA  . GLN A 1 96  ? -28.11235 -16.30246 -7.17121  1.000 14.95299 ? 85   GLN A CA  1 
ATOM   745  C C   . GLN A 1 96  ? -26.65626 -16.64220 -6.92090  1.000 16.34355 ? 85   GLN A C   1 
ATOM   746  O O   . GLN A 1 96  ? -26.31523 -17.79772 -6.64136  1.000 16.09637 ? 85   GLN A O   1 
ATOM   747  C CB  . GLN A 1 96  ? -28.82298 -16.01682 -5.84596  1.000 18.26174 ? 85   GLN A CB  1 
ATOM   748  C CG  . GLN A 1 96  ? -30.24760 -15.56779 -6.06263  1.000 24.01959 ? 85   GLN A CG  1 
ATOM   749  C CD  . GLN A 1 96  ? -30.61423 -14.38389 -5.21200  1.000 32.75985 ? 85   GLN A CD  1 
ATOM   750  O OE1 . GLN A 1 96  ? -30.13039 -14.23992 -4.08807  1.000 35.13068 ? 85   GLN A OE1 1 
ATOM   751  N NE2 . GLN A 1 96  ? -31.47154 -13.52027 -5.74239  1.000 41.19861 ? 85   GLN A NE2 1 
ATOM   752  N N   . ARG A 1 97  ? -25.79625 -15.63449 -7.01786  1.000 14.48163 ? 86   ARG A N   1 
ATOM   753  C CA  . ARG A 1 97  ? -24.38479 -15.87378 -6.76949  1.000 11.18083 ? 86   ARG A CA  1 
ATOM   754  C C   . ARG A 1 97  ? -23.81898 -14.69603 -6.00104  1.000 13.31176 ? 86   ARG A C   1 
ATOM   755  O O   . ARG A 1 97  ? -24.35327 -13.58345 -6.07821  1.000 13.63238 ? 86   ARG A O   1 
ATOM   756  C CB  . ARG A 1 97  ? -23.58289 -16.08979 -8.05638  1.000 14.63887 ? 86   ARG A CB  1 
ATOM   757  C CG  . ARG A 1 97  ? -23.48601 -14.84366 -8.89464  1.000 17.90379 ? 86   ARG A CG  1 
ATOM   758  C CD  . ARG A 1 97  ? -22.07740 -14.42183 -9.00370  1.000 16.31787 ? 86   ARG A CD  1 
ATOM   759  N NE  . ARG A 1 97  ? -21.89595 -13.46792 -10.09056 1.000 14.21032 ? 86   ARG A NE  1 
ATOM   760  C CZ  . ARG A 1 97  ? -20.96314 -12.53056 -10.08300 1.000 14.43108 ? 86   ARG A CZ  1 
ATOM   761  N NH1 . ARG A 1 97  ? -20.15904 -12.36587 -9.04122  1.000 13.46623 ? 86   ARG A NH1 1 
ATOM   762  N NH2 . ARG A 1 97  ? -20.82323 -11.75403 -11.14772 1.000 12.96806 ? 86   ARG A NH2 1 
ATOM   763  N N   . PRO A 1 98  ? -22.76779 -14.92794 -5.21793  1.000 14.84148 ? 87   PRO A N   1 
ATOM   764  C CA  . PRO A 1 98  ? -22.17579 -13.84044 -4.43285  1.000 14.03715 ? 87   PRO A CA  1 
ATOM   765  C C   . PRO A 1 98  ? -21.41207 -12.88246 -5.33126  1.000 14.80832 ? 87   PRO A C   1 
ATOM   766  O O   . PRO A 1 98  ? -20.68826 -13.29285 -6.24061  1.000 14.33573 ? 87   PRO A O   1 
ATOM   767  C CB  . PRO A 1 98  ? -21.23472 -14.56949 -3.46524  1.000 17.47637 ? 87   PRO A CB  1 
ATOM   768  C CG  . PRO A 1 98  ? -20.90636 -15.87077 -4.15077  1.000 18.86118 ? 87   PRO A CG  1 
ATOM   769  C CD  . PRO A 1 98  ? -22.15418 -16.23534 -4.92610  1.000 14.51348 ? 87   PRO A CD  1 
ATOM   770  N N   . LEU A 1 99  ? -21.60638 -11.59451 -5.08222  1.000 13.48342 ? 88   LEU A N   1 
ATOM   771  C CA  . LEU A 1 99  ? -20.89817 -10.53562 -5.78958  1.000 10.79949 ? 88   LEU A CA  1 
ATOM   772  C C   . LEU A 1 99  ? -20.18555 -9.69304  -4.74401  1.000 11.63763 ? 88   LEU A C   1 
ATOM   773  O O   . LEU A 1 99  ? -20.82876 -9.16290  -3.82758  1.000 12.60428 ? 88   LEU A O   1 
ATOM   774  C CB  . LEU A 1 99  ? -21.86384 -9.68756  -6.61232  1.000 12.16255 ? 88   LEU A CB  1 
ATOM   775  C CG  . LEU A 1 99  ? -21.31727 -8.43975  -7.32755  1.000 11.76381 ? 88   LEU A CG  1 
ATOM   776  C CD1 . LEU A 1 99  ? -20.18399 -8.81521  -8.26360  1.000 11.86924 ? 88   LEU A CD1 1 
ATOM   777  C CD2 . LEU A 1 99  ? -22.44736 -7.72992  -8.07200  1.000 11.99759 ? 88   LEU A CD2 1 
ATOM   778  N N   . LYS A 1 100 ? -18.86303 -9.60167  -4.86311  1.000 12.49535 ? 89   LYS A N   1 
ATOM   779  C CA  . LYS A 1 100 ? -18.03881 -8.89293  -3.88549  1.000 11.42709 ? 89   LYS A CA  1 
ATOM   780  C C   . LYS A 1 100 ? -17.96778 -7.41890  -4.27290  1.000 14.64354 ? 89   LYS A C   1 
ATOM   781  O O   . LYS A 1 100 ? -17.57527 -7.09426  -5.40324  1.000 14.14609 ? 89   LYS A O   1 
ATOM   782  C CB  . LYS A 1 100 ? -16.64185 -9.51244  -3.84465  1.000 15.24558 ? 89   LYS A CB  1 
ATOM   783  C CG  . LYS A 1 100 ? -16.59792 -10.80634 -3.03446  1.000 16.84457 ? 89   LYS A CG  1 
ATOM   784  C CD  . LYS A 1 100 ? -15.33857 -11.64104 -3.28301  1.000 17.91375 ? 89   LYS A CD  1 
ATOM   785  C CE  . LYS A 1 100 ? -14.93437 -11.76524 -4.75008  1.000 16.25048 ? 89   LYS A CE  1 
ATOM   786  N NZ  . LYS A 1 100 ? -13.68232 -12.57990 -4.80540  1.000 15.75223 ? 89   LYS A NZ  1 
ATOM   787  N N   . ILE A 1 101 ? -18.33424 -6.52744  -3.35184  1.000 10.95668 ? 90   ILE A N   1 
ATOM   788  C CA  . ILE A 1 101 ? -18.48737 -5.10763  -3.66032  1.000 12.92488 ? 90   ILE A CA  1 
ATOM   789  C C   . ILE A 1 101 ? -17.73753 -4.28423  -2.62758  1.000 15.15879 ? 90   ILE A C   1 
ATOM   790  O O   . ILE A 1 101 ? -17.97852 -4.43147  -1.42447  1.000 14.78936 ? 90   ILE A O   1 
ATOM   791  C CB  . ILE A 1 101 ? -19.96491 -4.67267  -3.68358  1.000 14.68779 ? 90   ILE A CB  1 
ATOM   792  C CG1 . ILE A 1 101 ? -20.74961 -5.48493  -4.71020  1.000 13.25728 ? 90   ILE A CG1 1 
ATOM   793  C CG2 . ILE A 1 101 ? -20.06645 -3.18388  -4.02898  1.000 13.75133 ? 90   ILE A CG2 1 
ATOM   794  C CD1 . ILE A 1 101 ? -20.35053 -5.16111  -6.15824  1.000 13.76750 ? 90   ILE A CD1 1 
ATOM   795  N N   . ARG A 1 102 ? -16.87212 -3.38369  -3.09083  1.000 12.35330 ? 91   ARG A N   1 
ATOM   796  C CA  . ARG A 1 102 ? -16.20649 -2.46574  -2.16665  1.000 13.73191 ? 91   ARG A CA  1 
ATOM   797  C C   . ARG A 1 102 ? -17.16737 -1.33079  -1.80713  1.000 16.97159 ? 91   ARG A C   1 
ATOM   798  O O   . ARG A 1 102 ? -17.61390 -0.57034  -2.68020  1.000 13.27465 ? 91   ARG A O   1 
ATOM   799  C CB  . ARG A 1 102 ? -14.90167 -1.91595  -2.74674  1.000 15.35156 ? 91   ARG A CB  1 
ATOM   800  C CG  . ARG A 1 102 ? -14.07692 -1.12926  -1.70237  1.000 17.04659 ? 91   ARG A CG  1 
ATOM   801  C CD  . ARG A 1 102 ? -12.67821 -0.75264  -2.19813  1.000 18.51142 ? 91   ARG A CD  1 
ATOM   802  N NE  . ARG A 1 102 ? -11.99751 -1.87519  -2.82910  1.000 22.99038 ? 91   ARG A NE  1 
ATOM   803  C CZ  . ARG A 1 102 ? -11.43110 -2.87698  -2.16973  1.000 25.59661 ? 91   ARG A CZ  1 
ATOM   804  N NH1 . ARG A 1 102 ? -11.38467 -2.89400  -0.84597  1.000 22.33647 ? 91   ARG A NH1 1 
ATOM   805  N NH2 . ARG A 1 102 ? -10.88472 -3.88057  -2.85632  1.000 23.13633 ? 91   ARG A NH2 1 
ATOM   806  N N   . MET A 1 103 ? -17.49165 -1.23736  -0.52057  1.000 14.20769 ? 92   MET A N   1 
ATOM   807  C CA  . MET A 1 103 ? -18.37171 -0.21768  0.00621   1.000 12.39783 ? 92   MET A CA  1 
ATOM   808  C C   . MET A 1 103 ? -17.71107 1.14768   0.07497   1.000 12.81609 ? 92   MET A C   1 
ATOM   809  O O   . MET A 1 103 ? -16.50195 1.31021   -0.08167  1.000 16.63864 ? 92   MET A O   1 
ATOM   810  C CB  . MET A 1 103 ? -18.85691 -0.58352  1.40231   1.000 16.24746 ? 92   MET A CB  1 
ATOM   811  C CG  . MET A 1 103 ? -19.49890 -1.93358  1.64298   1.000 15.37304 ? 92   MET A CG  1 
ATOM   812  S SD  . MET A 1 103 ? -21.16920 -2.02873  0.91845   1.000 19.49703 ? 92   MET A SD  1 
ATOM   813  C CE  . MET A 1 103 ? -20.99907 -2.12618  -0.86989  1.000 14.59065 ? 92   MET A CE  1 
ATOM   814  N N   . LEU A 1 104 ? -18.54554 2.13350   0.39774   1.000 16.67150 ? 93   LEU A N   1 
ATOM   815  C CA  . LEU A 1 104 ? -18.09494 3.51197   0.47460   1.000 15.79796 ? 93   LEU A CA  1 
ATOM   816  C C   . LEU A 1 104 ? -17.15934 3.76921   1.64648   1.000 16.89799 ? 93   LEU A C   1 
ATOM   817  O O   . LEU A 1 104 ? -16.53357 4.83158   1.67789   1.000 21.82316 ? 93   LEU A O   1 
ATOM   818  C CB  . LEU A 1 104 ? -19.31399 4.44134   0.54404   1.000 14.77255 ? 93   LEU A CB  1 
ATOM   819  C CG  . LEU A 1 104 ? -20.28873 4.29218   -0.63245  1.000 16.03638 ? 93   LEU A CG  1 
ATOM   820  C CD1 . LEU A 1 104 ? -21.65722 4.88720   -0.29286  1.000 14.78633 ? 93   LEU A CD1 1 
ATOM   821  C CD2 . LEU A 1 104 ? -19.71679 4.94657   -1.90117  1.000 17.84386 ? 93   LEU A CD2 1 
ATOM   822  N N   . ASP A 1 105 ? -17.05569 2.85072   2.60706   1.000 15.31060 ? 94   ASP A N   1 
ATOM   823  C CA  . ASP A 1 105 ? -16.07502 2.96461   3.67896   1.000 19.75019 ? 94   ASP A CA  1 
ATOM   824  C C   . ASP A 1 105 ? -14.80204 2.18725   3.37023   1.000 21.16970 ? 94   ASP A C   1 
ATOM   825  O O   . ASP A 1 105 ? -13.91766 2.08417   4.22721   1.000 20.40766 ? 94   ASP A O   1 
ATOM   826  C CB  . ASP A 1 105 ? -16.69227 2.52401   5.01665   1.000 20.12124 ? 94   ASP A CB  1 
ATOM   827  C CG  . ASP A 1 105 ? -16.92005 1.02118   5.11520   1.000 23.10531 ? 94   ASP A CG  1 
ATOM   828  O OD1 . ASP A 1 105 ? -16.80488 0.29674   4.08914   1.000 18.06017 ? 94   ASP A OD1 1 
ATOM   829  O OD2 . ASP A 1 105 ? -17.27139 0.56268   6.22952   1.000 20.18995 ? 94   ASP A OD2 1 
ATOM   830  N N   . GLY A 1 106 ? -14.68668 1.65186   2.15710   1.000 18.95506 ? 95   GLY A N   1 
ATOM   831  C CA  . GLY A 1 106 ? -13.50103 0.93092   1.73795   1.000 20.51716 ? 95   GLY A CA  1 
ATOM   832  C C   . GLY A 1 106 ? -13.48854 -0.54264  2.07165   1.000 21.79946 ? 95   GLY A C   1 
ATOM   833  O O   . GLY A 1 106 ? -12.59412 -1.25662  1.59936   1.000 19.75395 ? 95   GLY A O   1 
ATOM   834  N N   . THR A 1 107 ? -14.43559 -1.02451  2.87542   1.000 19.33038 ? 96   THR A N   1 
ATOM   835  C CA  . THR A 1 107 ? -14.49833 -2.45293  3.14346   1.000 18.83443 ? 96   THR A CA  1 
ATOM   836  C C   . THR A 1 107 ? -15.23218 -3.16300  2.00879   1.000 17.64361 ? 96   THR A C   1 
ATOM   837  O O   . THR A 1 107 ? -15.95219 -2.54423  1.22578   1.000 19.06706 ? 96   THR A O   1 
ATOM   838  C CB  . THR A 1 107 ? -15.22048 -2.73794  4.45781   1.000 17.73933 ? 96   THR A CB  1 
ATOM   839  O OG1 . THR A 1 107 ? -16.56183 -2.25081  4.38253   1.000 22.58187 ? 96   THR A OG1 1 
ATOM   840  C CG2 . THR A 1 107 ? -14.50890 -2.02192  5.62070   1.000 22.94751 ? 96   THR A CG2 1 
ATOM   841  N N   . VAL A 1 108 ? -15.06035 -4.47885  1.94146   1.000 18.35720 ? 97   VAL A N   1 
ATOM   842  C CA  . VAL A 1 108 ? -15.70885 -5.30189  0.91929   1.000 18.35266 ? 97   VAL A CA  1 
ATOM   843  C C   . VAL A 1 108 ? -16.85893 -6.06655  1.56045   1.000 20.37294 ? 97   VAL A C   1 
ATOM   844  O O   . VAL A 1 108 ? -16.70642 -6.66523  2.63535   1.000 18.90313 ? 97   VAL A O   1 
ATOM   845  C CB  . VAL A 1 108 ? -14.70979 -6.26160  0.25675   1.000 18.09663 ? 97   VAL A CB  1 
ATOM   846  C CG1 . VAL A 1 108 ? -15.43367 -7.19982  -0.72316  1.000 20.52954 ? 97   VAL A CG1 1 
ATOM   847  C CG2 . VAL A 1 108 ? -13.63663 -5.48757  -0.45232  1.000 21.03830 ? 97   VAL A CG2 1 
ATOM   848  N N   . LYS A 1 109 ? -18.01287 -6.04649  0.90551   1.000 14.89337 ? 98   LYS A N   1 
ATOM   849  C CA  . LYS A 1 109 ? -19.20233 -6.75369  1.36774   1.000 15.30676 ? 98   LYS A CA  1 
ATOM   850  C C   . LYS A 1 109 ? -19.67156 -7.66711  0.25080   1.000 18.42084 ? 98   LYS A C   1 
ATOM   851  O O   . LYS A 1 109 ? -19.69909 -7.26096  -0.91410  1.000 14.38198 ? 98   LYS A O   1 
ATOM   852  C CB  . LYS A 1 109 ? -20.32177 -5.77479  1.76405   1.000 16.81105 ? 98   LYS A CB  1 
ATOM   853  C CG  . LYS A 1 109 ? -21.54373 -6.45816  2.41384   1.000 21.46734 ? 98   LYS A CG  1 
ATOM   854  C CD  . LYS A 1 109 ? -22.73439 -5.51393  2.60895   1.000 22.27527 ? 98   LYS A CD  1 
ATOM   855  C CE  . LYS A 1 109 ? -23.94992 -6.26507  3.17401   1.000 28.44026 ? 98   LYS A CE  1 
ATOM   856  N NZ  . LYS A 1 109 ? -23.64931 -7.00811  4.44519   1.000 31.81893 ? 98   LYS A NZ  1 
ATOM   857  N N   . THR A 1 110 ? -19.99852 -8.90339  0.59720   1.000 15.57794 ? 99   THR A N   1 
ATOM   858  C CA  . THR A 1 110 ? -20.47507 -9.86858  -0.38273  1.000 17.85252 ? 99   THR A CA  1 
ATOM   859  C C   . THR A 1 110 ? -21.99206 -9.86334  -0.40463  1.000 17.12107 ? 99   THR A C   1 
ATOM   860  O O   . THR A 1 110 ? -22.63945 -10.06815 0.62845   1.000 18.03788 ? 99   THR A O   1 
ATOM   861  C CB  . THR A 1 110 ? -19.92758 -11.26381 -0.08923  1.000 17.21079 ? 99   THR A CB  1 
ATOM   862  O OG1 . THR A 1 110 ? -18.50259 -11.18876 0.07762   1.000 22.53108 ? 99   THR A OG1 1 
ATOM   863  C CG2 . THR A 1 110 ? -20.27301 -12.19549 -1.21307  1.000 18.08261 ? 99   THR A CG2 1 
ATOM   864  N N   . ILE A 1 111 ? -22.55695 -9.61123  -1.58012  1.000 15.94829 ? 100  ILE A N   1 
ATOM   865  C CA  . ILE A 1 111 ? -23.99625 -9.48597  -1.75620  1.000 15.58238 ? 100  ILE A CA  1 
ATOM   866  C C   . ILE A 1 111 ? -24.47160 -10.49562 -2.78979  1.000 15.59436 ? 100  ILE A C   1 
ATOM   867  O O   . ILE A 1 111 ? -23.89923 -10.60611 -3.87952  1.000 13.50916 ? 100  ILE A O   1 
ATOM   868  C CB  . ILE A 1 111 ? -24.38867 -8.04643  -2.14844  1.000 20.04147 ? 100  ILE A CB  1 
ATOM   869  C CG1 . ILE A 1 111 ? -23.83566 -7.05224  -1.10819  1.000 20.42957 ? 100  ILE A CG1 1 
ATOM   870  C CG2 . ILE A 1 111 ? -25.88358 -7.93375  -2.39132  1.000 18.58383 ? 100  ILE A CG2 1 
ATOM   871  C CD1 . ILE A 1 111 ? -24.08588 -5.59360  -1.42843  1.000 25.50775 ? 100  ILE A CD1 1 
ATOM   872  N N   . MET A 1 112 ? -25.53112 -11.22440 -2.45531  1.000 14.88352 ? 101  MET A N   1 
ATOM   873  C CA  . MET A 1 112 ? -26.08432 -12.16757 -3.41131  1.000 15.35626 ? 101  MET A CA  1 
ATOM   874  C C   . MET A 1 112 ? -26.93282 -11.44083 -4.44403  1.000 14.91254 ? 101  MET A C   1 
ATOM   875  O O   . MET A 1 112 ? -27.78867 -10.61347 -4.09934  1.000 17.26813 ? 101  MET A O   1 
ATOM   876  C CB  . MET A 1 112 ? -26.87453 -13.24910 -2.69148  1.000 18.27510 ? 101  MET A CB  1 
ATOM   877  C CG  . MET A 1 112 ? -26.00792 -13.73178 -1.56733  1.000 20.66115 ? 101  MET A CG  1 
ATOM   878  S SD  . MET A 1 112 ? -24.91042 -15.00952 -2.18223  1.000 19.79933 ? 101  MET A SD  1 
ATOM   879  C CE  . MET A 1 112 ? -25.92733 -15.87984 -3.37403  1.000 21.17832 ? 101  MET A CE  1 
ATOM   880  N N   . VAL A 1 113 ? -26.68120 -11.74014 -5.72060  1.000 13.62863 ? 102  VAL A N   1 
ATOM   881  C CA  . VAL A 1 113 ? -27.39045 -11.09551 -6.81745  1.000 14.06767 ? 102  VAL A CA  1 
ATOM   882  C C   . VAL A 1 113 ? -27.90555 -12.17390 -7.76103  1.000 15.65589 ? 102  VAL A C   1 
ATOM   883  O O   . VAL A 1 113 ? -27.38189 -13.28729 -7.81693  1.000 14.68223 ? 102  VAL A O   1 
ATOM   884  C CB  . VAL A 1 113 ? -26.51716 -10.08521 -7.60871  1.000 15.53377 ? 102  VAL A CB  1 
ATOM   885  C CG1 . VAL A 1 113 ? -26.14596 -8.87918  -6.73226  1.000 13.08343 ? 102  VAL A CG1 1 
ATOM   886  C CG2 . VAL A 1 113 ? -25.29093 -10.76091 -8.24419  1.000 14.16628 ? 102  VAL A CG2 1 
ATOM   887  N N   . ASP A 1 114 ? -28.93355 -11.81156 -8.52423  1.000 14.92560 ? 103  ASP A N   1 
ATOM   888  C CA  . ASP A 1 114 ? -29.44345 -12.65682 -9.60319  1.000 19.01616 ? 103  ASP A CA  1 
ATOM   889  C C   . ASP A 1 114 ? -28.44541 -12.66237 -10.75616 1.000 12.16723 ? 103  ASP A C   1 
ATOM   890  O O   . ASP A 1 114 ? -28.26381 -11.64640 -11.43083 1.000 14.38985 ? 103  ASP A O   1 
ATOM   891  C CB  . ASP A 1 114 ? -30.80319 -12.13601 -10.06434 1.000 18.01476 ? 103  ASP A CB  1 
ATOM   892  C CG  . ASP A 1 114 ? -31.48264 -13.05260 -11.06819 1.000 20.25213 ? 103  ASP A CG  1 
ATOM   893  O OD1 . ASP A 1 114 ? -30.79336 -13.80158 -11.79255 1.000 17.08964 ? 103  ASP A OD1 1 
ATOM   894  O OD2 . ASP A 1 114 ? -32.72183 -12.99844 -11.16842 1.000 23.95036 ? 103  ASP A OD2 1 
ATOM   895  N N   . ASP A 1 115 ? -27.81990 -13.80839 -11.00532 1.000 14.02877 ? 104  ASP A N   1 
ATOM   896  C CA  . ASP A 1 115 ? -26.71360 -13.87867 -11.95966 1.000 13.68277 ? 104  ASP A CA  1 
ATOM   897  C C   . ASP A 1 115 ? -27.15205 -13.76648 -13.41478 1.000 15.04029 ? 104  ASP A C   1 
ATOM   898  O O   . ASP A 1 115 ? -26.28865 -13.70137 -14.30168 1.000 13.51371 ? 104  ASP A O   1 
ATOM   899  C CB  . ASP A 1 115 ? -25.95343 -15.19183 -11.77535 1.000 13.66948 ? 104  ASP A CB  1 
ATOM   900  C CG  . ASP A 1 115 ? -24.60939 -15.19813 -12.50818 1.000 12.81355 ? 104  ASP A CG  1 
ATOM   901  O OD1 . ASP A 1 115 ? -23.77239 -14.30928 -12.26693 1.000 12.96895 ? 104  ASP A OD1 1 
ATOM   902  O OD2 . ASP A 1 115 ? -24.40634 -16.08296 -13.35002 1.000 13.81678 ? 104  ASP A OD2 1 
ATOM   903  N N   . SER A 1 116 ? -28.45132 -13.74932 -13.69040 1.000 9.92318  ? 105  SER A N   1 
ATOM   904  C CA  . SER A 1 116 ? -28.94115 -13.59843 -15.05659 1.000 12.86862 ? 105  SER A CA  1 
ATOM   905  C C   . SER A 1 116 ? -29.20563 -12.15105 -15.44219 1.000 14.70106 ? 105  SER A C   1 
ATOM   906  O O   . SER A 1 116 ? -29.60920 -11.89287 -16.58283 1.000 16.25001 ? 105  SER A O   1 
ATOM   907  C CB  . SER A 1 116 ? -30.22409 -14.42239 -15.24726 1.000 18.25666 ? 105  SER A CB  1 
ATOM   908  O OG  . SER A 1 116 ? -31.31389 -13.84645 -14.53965 1.000 15.84900 ? 105  SER A OG  1 
ATOM   909  N N   . LYS A 1 117 ? -28.98869 -11.21002 -14.53169 1.000 13.41599 ? 106  LYS A N   1 
ATOM   910  C CA  . LYS A 1 117 ? -29.46119 -9.83977  -14.68436 1.000 18.98748 ? 106  LYS A CA  1 
ATOM   911  C C   . LYS A 1 117 ? -28.33995 -8.90530  -15.14566 1.000 18.03002 ? 106  LYS A C   1 
ATOM   912  O O   . LYS A 1 117 ? -27.17433 -9.29798  -15.26428 1.000 14.48205 ? 106  LYS A O   1 
ATOM   913  C CB  . LYS A 1 117 ? -30.05691 -9.35470  -13.36282 1.000 18.03189 ? 106  LYS A CB  1 
ATOM   914  C CG  . LYS A 1 117 ? -31.40116 -10.00566 -12.97099 1.000 20.50042 ? 106  LYS A CG  1 
ATOM   915  C CD  . LYS A 1 117 ? -32.31085 -10.27911 -14.16981 1.000 22.55040 ? 106  LYS A CD  1 
ATOM   916  C CE  . LYS A 1 117 ? -33.55402 -11.08894 -13.75776 1.000 25.55003 ? 106  LYS A CE  1 
ATOM   917  N NZ  . LYS A 1 117 ? -34.78546 -10.70733 -14.49969 1.000 34.32903 ? 106  LYS A NZ  1 
ATOM   918  N N   . THR A 1 118 ? -28.71732 -7.64744  -15.42690 1.000 13.72273 ? 107  THR A N   1 
ATOM   919  C CA  . THR A 1 118 ? -27.77438 -6.64941  -15.91508 1.000 14.37147 ? 107  THR A CA  1 
ATOM   920  C C   . THR A 1 118 ? -27.09455 -5.95559  -14.74615 1.000 15.94596 ? 107  THR A C   1 
ATOM   921  O O   . THR A 1 118 ? -27.48925 -6.10369  -13.59146 1.000 13.90746 ? 107  THR A O   1 
ATOM   922  C CB  . THR A 1 118 ? -28.46814 -5.58911  -16.76934 1.000 19.38283 ? 107  THR A CB  1 
ATOM   923  O OG1 . THR A 1 118 ? -29.35098 -4.83353  -15.93655 1.000 18.48994 ? 107  THR A OG1 1 
ATOM   924  C CG2 . THR A 1 118 ? -29.26170 -6.23933  -17.89748 1.000 19.96527 ? 107  THR A CG2 1 
ATOM   925  N N   . VAL A 1 119 ? -26.08500 -5.14313  -15.07228 1.000 12.84058 ? 108  VAL A N   1 
ATOM   926  C CA  . VAL A 1 119 ? -25.35584 -4.41283  -14.03477 1.000 12.90159 ? 108  VAL A CA  1 
ATOM   927  C C   . VAL A 1 119 ? -26.28726 -3.49236  -13.25663 1.000 12.72999 ? 108  VAL A C   1 
ATOM   928  O O   . VAL A 1 119 ? -26.18153 -3.37406  -12.03103 1.000 12.90523 ? 108  VAL A O   1 
ATOM   929  C CB  . VAL A 1 119 ? -24.18185 -3.63436  -14.65737 1.000 12.78953 ? 108  VAL A CB  1 
ATOM   930  C CG1 . VAL A 1 119 ? -23.49977 -2.81890  -13.59096 1.000 17.28410 ? 108  VAL A CG1 1 
ATOM   931  C CG2 . VAL A 1 119 ? -23.16644 -4.60816  -15.23578 1.000 14.06765 ? 108  VAL A CG2 1 
ATOM   932  N N   . THR A 1 120 ? -27.21104 -2.81739  -13.95222 1.000 13.94521 ? 109  THR A N   1 
ATOM   933  C CA  . THR A 1 120 ? -28.18278 -1.96999  -13.25925 1.000 13.07506 ? 109  THR A CA  1 
ATOM   934  C C   . THR A 1 120 ? -28.98568 -2.76011  -12.23361 1.000 14.48590 ? 109  THR A C   1 
ATOM   935  O O   . THR A 1 120 ? -29.19035 -2.30432  -11.09516 1.000 15.35925 ? 109  THR A O   1 
ATOM   936  C CB  . THR A 1 120 ? -29.12520 -1.30756  -14.26750 1.000 17.93597 ? 109  THR A CB  1 
ATOM   937  O OG1 . THR A 1 120 ? -28.43776 -0.23943  -14.92096 1.000 22.58499 ? 109  THR A OG1 1 
ATOM   938  C CG2 . THR A 1 120 ? -30.37298 -0.75419  -13.55590 1.000 22.04729 ? 109  THR A CG2 1 
ATOM   939  N N   . ASP A 1 121 ? -29.47718 -3.94136  -12.63010 1.000 14.68377 ? 110  ASP A N   1 
ATOM   940  C CA  . ASP A 1 121 ? -30.20536 -4.80655  -11.69732 1.000 15.00998 ? 110  ASP A CA  1 
ATOM   941  C C   . ASP A 1 121 ? -29.36223 -5.16632  -10.47939 1.000 18.14680 ? 110  ASP A C   1 
ATOM   942  O O   . ASP A 1 121 ? -29.84677 -5.09282  -9.33438  1.000 17.48416 ? 110  ASP A O   1 
ATOM   943  C CB  . ASP A 1 121 ? -30.68406 -6.08246  -12.39858 1.000 18.55510 ? 110  ASP A CB  1 
ATOM   944  C CG  . ASP A 1 121 ? -31.57685 -5.79319  -13.58498 1.000 26.76604 ? 110  ASP A CG  1 
ATOM   945  O OD1 . ASP A 1 121 ? -32.36953 -4.84069  -13.48491 1.000 25.72249 ? 110  ASP A OD1 1 
ATOM   946  O OD2 . ASP A 1 121 ? -31.48211 -6.51454  -14.61428 1.000 33.11821 ? 110  ASP A OD2 1 
ATOM   947  N N   . MET A 1 122 ? -28.12069 -5.64090  -10.69431 1.000 16.87285 ? 111  MET A N   1 
ATOM   948  C CA  . MET A 1 122 ? -27.33677 -5.94233  -9.49418  1.000 16.55014 ? 111  MET A CA  1 
ATOM   949  C C   . MET A 1 122 ? -26.99426 -4.69707  -8.68276  1.000 16.41571 ? 111  MET A C   1 
ATOM   950  O O   . MET A 1 122 ? -27.00415 -4.77616  -7.44685  1.000 15.30983 ? 111  MET A O   1 
ATOM   951  C CB  . MET A 1 122 ? -26.10363 -6.82455  -9.75083  1.000 19.08171 ? 111  MET A CB  1 
ATOM   952  C CG  . MET A 1 122 ? -26.20726 -7.85027  -10.88997 1.000 12.41125 ? 111  MET A CG  1 
ATOM   953  S SD  . MET A 1 122 ? -24.62238 -8.50212  -11.44295 1.000 13.72115 ? 111  MET A SD  1 
ATOM   954  C CE  . MET A 1 122 ? -25.18120 -10.12968 -11.96034 1.000 13.95625 ? 111  MET A CE  1 
ATOM   955  N N   . LEU A 1 123 ? -26.79779 -3.53825  -9.31798  1.000 12.79731 ? 112  LEU A N   1 
ATOM   956  C CA  . LEU A 1 123 ? -26.62968 -2.31437  -8.52615  1.000 15.59828 ? 112  LEU A CA  1 
ATOM   957  C C   . LEU A 1 123 ? -27.84641 -2.04855  -7.64225  1.000 13.04004 ? 112  LEU A C   1 
ATOM   958  O O   . LEU A 1 123 ? -27.70043 -1.68803  -6.45774  1.000 14.79084 ? 112  LEU A O   1 
ATOM   959  C CB  . LEU A 1 123 ? -26.35598 -1.12427  -9.44744  1.000 16.63557 ? 112  LEU A CB  1 
ATOM   960  C CG  . LEU A 1 123 ? -26.31971 0.26874   -8.80732  1.000 17.12910 ? 112  LEU A CG  1 
ATOM   961  C CD1 . LEU A 1 123 ? -25.13169 0.37823   -7.84962  1.000 16.91272 ? 112  LEU A CD1 1 
ATOM   962  C CD2 . LEU A 1 123 ? -26.22931 1.34655   -9.88668  1.000 16.88883 ? 112  LEU A CD2 1 
ATOM   963  N N   . MET A 1 124 ? -29.06168 -2.24454  -8.18133  1.000 13.40713 ? 113  MET A N   1 
ATOM   964  C CA  . MET A 1 124 ? -30.25037 -2.00824  -7.36067  1.000 16.09179 ? 113  MET A CA  1 
ATOM   965  C C   . MET A 1 124 ? -30.31876 -2.97358  -6.18471  1.000 16.57285 ? 113  MET A C   1 
ATOM   966  O O   . MET A 1 124 ? -30.75823 -2.59529  -5.09028  1.000 16.36772 ? 113  MET A O   1 
ATOM   967  C CB  . MET A 1 124 ? -31.54809 -2.10470  -8.16793  1.000 20.16797 ? 113  MET A CB  1 
ATOM   968  C CG  . MET A 1 124 ? -31.93745 -0.85984  -8.95862  1.000 25.39892 ? 113  MET A CG  1 
ATOM   969  S SD  . MET A 1 124 ? -32.81958 -1.26503  -10.48271 1.000 30.97770 ? 113  MET A SD  1 
ATOM   970  C CE  . MET A 1 124 ? -34.42289 -1.62268  -9.77749  1.000 30.58565 ? 113  MET A CE  1 
ATOM   971  N N   . THR A 1 125 ? -29.92695 -4.23641  -6.40061  1.000 12.76439 ? 114  THR A N   1 
ATOM   972  C CA  . THR A 1 125 ? -29.89753 -5.20874  -5.31378  1.000 17.73026 ? 114  THR A CA  1 
ATOM   973  C C   . THR A 1 125 ? -28.92176 -4.77320  -4.22799  1.000 16.35686 ? 114  THR A C   1 
ATOM   974  O O   . THR A 1 125 ? -29.24019 -4.80750  -3.02145  1.000 15.05567 ? 114  THR A O   1 
ATOM   975  C CB  . THR A 1 125 ? -29.50564 -6.58741  -5.85764  1.000 18.87717 ? 114  THR A CB  1 
ATOM   976  O OG1 . THR A 1 125 ? -30.47998 -7.03481  -6.80275  1.000 18.02015 ? 114  THR A OG1 1 
ATOM   977  C CG2 . THR A 1 125 ? -29.40466 -7.61421  -4.71396  1.000 14.42857 ? 114  THR A CG2 1 
ATOM   978  N N   . ILE A 1 126 ? -27.71452 -4.36727  -4.64781  1.000 15.43846 ? 115  ILE A N   1 
ATOM   979  C CA  . ILE A 1 126 ? -26.71201 -3.85165  -3.71624  1.000 15.21414 ? 115  ILE A CA  1 
ATOM   980  C C   . ILE A 1 126 ? -27.29153 -2.69186  -2.90866  1.000 16.30680 ? 115  ILE A C   1 
ATOM   981  O O   . ILE A 1 126 ? -27.29333 -2.71155  -1.67146  1.000 16.76141 ? 115  ILE A O   1 
ATOM   982  C CB  . ILE A 1 126 ? -25.42980 -3.43359  -4.47566  1.000 16.41242 ? 115  ILE A CB  1 
ATOM   983  C CG1 . ILE A 1 126 ? -24.71496 -4.65948  -5.06397  1.000 17.38550 ? 115  ILE A CG1 1 
ATOM   984  C CG2 . ILE A 1 126 ? -24.47131 -2.62907  -3.56098  1.000 15.04422 ? 115  ILE A CG2 1 
ATOM   985  C CD1 . ILE A 1 126 ? -23.95879 -4.34128  -6.36969  1.000 14.50461 ? 115  ILE A CD1 1 
ATOM   986  N N   . CYS A 1 127 ? -27.83423 -1.68833  -3.59900  1.000 16.71535 ? 116  CYS A N   1 
ATOM   987  C CA  . CYS A 1 127 ? -28.34727 -0.50569  -2.90999  1.000 16.46271 ? 116  CYS A CA  1 
ATOM   988  C C   . CYS A 1 127 ? -29.48340 -0.85175  -1.95321  1.000 17.50279 ? 116  CYS A C   1 
ATOM   989  O O   . CYS A 1 127 ? -29.56610 -0.28993  -0.84993  1.000 18.26240 ? 116  CYS A O   1 
ATOM   990  C CB  . CYS A 1 127 ? -28.79137 0.54720   -3.93051  1.000 14.18992 ? 116  CYS A CB  1 
ATOM   991  S SG  . CYS A 1 127 ? -27.39031 1.33958   -4.75063  1.000 17.87211 ? 116  CYS A SG  1 
ATOM   992  N N   . ALA A 1 128 ? -30.34811 -1.79961  -2.33626  1.000 19.00069 ? 117  ALA A N   1 
ATOM   993  C CA  . ALA A 1 128 ? -31.40423 -2.23746  -1.42905  1.000 23.03439 ? 117  ALA A CA  1 
ATOM   994  C C   . ALA A 1 128 ? -30.82460 -2.85484  -0.16027  1.000 21.62962 ? 117  ALA A C   1 
ATOM   995  O O   . ALA A 1 128 ? -31.32521 -2.60447  0.94680   1.000 22.41873 ? 117  ALA A O   1 
ATOM   996  C CB  . ALA A 1 128 ? -32.33165 -3.22700  -2.13590  1.000 19.66894 ? 117  ALA A CB  1 
ATOM   997  N N   . ARG A 1 129 ? -29.75391 -3.64700  -0.29666  1.000 17.97834 ? 118  ARG A N   1 
ATOM   998  C CA  A ARG A 1 129 ? -29.18363 -4.30383  0.87991   0.622 17.95074 ? 118  ARG A CA  1 
ATOM   999  C CA  B ARG A 1 129 ? -29.14086 -4.30831  0.85061   0.378 17.81551 ? 118  ARG A CA  1 
ATOM   1000 C C   . ARG A 1 129 ? -28.54948 -3.31101  1.84556   1.000 22.70238 ? 118  ARG A C   1 
ATOM   1001 O O   . ARG A 1 129 ? -28.56068 -3.55504  3.06032   1.000 20.02742 ? 118  ARG A O   1 
ATOM   1002 C CB  A ARG A 1 129 ? -28.14452 -5.35792  0.49677   0.622 20.40688 ? 118  ARG A CB  1 
ATOM   1003 C CB  B ARG A 1 129 ? -28.04172 -5.25163  0.36960   0.378 20.33603 ? 118  ARG A CB  1 
ATOM   1004 C CG  A ARG A 1 129 ? -28.70852 -6.55889  -0.23946  0.622 16.87716 ? 118  ARG A CG  1 
ATOM   1005 C CG  B ARG A 1 129 ? -27.40232 -6.04123  1.47178   0.378 20.67153 ? 118  ARG A CG  1 
ATOM   1006 C CD  A ARG A 1 129 ? -29.47949 -7.46405  0.69365   0.622 23.06633 ? 118  ARG A CD  1 
ATOM   1007 C CD  B ARG A 1 129 ? -28.35124 -7.10529  1.98841   0.378 23.00373 ? 118  ARG A CD  1 
ATOM   1008 N NE  A ARG A 1 129 ? -30.88137 -7.06391  0.76765   0.622 24.82345 ? 118  ARG A NE  1 
ATOM   1009 N NE  B ARG A 1 129 ? -27.76656 -7.78291  3.13528   0.378 26.61474 ? 118  ARG A NE  1 
ATOM   1010 C CZ  A ARG A 1 129 ? -31.71755 -7.02997  -0.26162  0.622 25.65066 ? 118  ARG A CZ  1 
ATOM   1011 C CZ  B ARG A 1 129 ? -27.94663 -7.38089  4.38187   0.378 27.91419 ? 118  ARG A CZ  1 
ATOM   1012 N NH1 A ARG A 1 129 ? -31.35541 -7.44462  -1.46417  0.622 30.30778 ? 118  ARG A NH1 1 
ATOM   1013 N NH1 B ARG A 1 129 ? -28.80020 -6.40986  4.67174   0.378 25.96550 ? 118  ARG A NH1 1 
ATOM   1014 N NH2 A ARG A 1 129 ? -32.95550 -6.58174  -0.07637  0.622 32.54202 ? 118  ARG A NH2 1 
ATOM   1015 N NH2 B ARG A 1 129 ? -27.26120 -7.96762  5.35940   0.378 29.31422 ? 118  ARG A NH2 1 
ATOM   1016 N N   . ILE A 1 130 ? -27.98979 -2.20545  1.35813   1.000 17.50162 ? 119  ILE A N   1 
ATOM   1017 C CA  . ILE A 1 130 ? -27.30996 -1.26135  2.25310   1.000 15.64948 ? 119  ILE A CA  1 
ATOM   1018 C C   . ILE A 1 130 ? -28.11218 0.02862   2.43408   1.000 18.91568 ? 119  ILE A C   1 
ATOM   1019 O O   . ILE A 1 130 ? -27.56234 1.04824   2.88082   1.000 17.78610 ? 119  ILE A O   1 
ATOM   1020 C CB  . ILE A 1 130 ? -25.87270 -0.96262  1.79558   1.000 19.56783 ? 119  ILE A CB  1 
ATOM   1021 C CG1 . ILE A 1 130 ? -25.85861 -0.23488  0.44668   1.000 16.03001 ? 119  ILE A CG1 1 
ATOM   1022 C CG2 . ILE A 1 130 ? -25.02085 -2.25895  1.80644   1.000 16.76660 ? 119  ILE A CG2 1 
ATOM   1023 C CD1 . ILE A 1 130 ? -24.45000 0.12919   -0.01103  1.000 17.42924 ? 119  ILE A CD1 1 
ATOM   1024 N N   . GLY A 1 131 ? -29.39893 0.00382   2.10801   1.000 14.09155 ? 120  GLY A N   1 
ATOM   1025 C CA  . GLY A 1 131 ? -30.28202 1.10363   2.45470   1.000 19.39635 ? 120  GLY A CA  1 
ATOM   1026 C C   . GLY A 1 131 ? -30.14173 2.36763   1.63279   1.000 23.25634 ? 120  GLY A C   1 
ATOM   1027 O O   . GLY A 1 131 ? -30.40560 3.45948   2.14482   1.000 22.31982 ? 120  GLY A O   1 
ATOM   1028 N N   . ILE A 1 132 ? -29.73902 2.25945   0.36971   1.000 16.37255 ? 121  ILE A N   1 
ATOM   1029 C CA  . ILE A 1 132 ? -29.63663 3.40322   -0.52266  1.000 18.52386 ? 121  ILE A CA  1 
ATOM   1030 C C   . ILE A 1 132 ? -30.86783 3.40285   -1.41861  1.000 21.16837 ? 121  ILE A C   1 
ATOM   1031 O O   . ILE A 1 132 ? -31.08140 2.46365   -2.19050  1.000 20.99108 ? 121  ILE A O   1 
ATOM   1032 C CB  . ILE A 1 132 ? -28.35051 3.33949   -1.35835  1.000 15.94594 ? 121  ILE A CB  1 
ATOM   1033 C CG1 . ILE A 1 132 ? -27.12384 3.45452   -0.44246  1.000 13.74090 ? 121  ILE A CG1 1 
ATOM   1034 C CG2 . ILE A 1 132 ? -28.37051 4.42701   -2.43842  1.000 18.75426 ? 121  ILE A CG2 1 
ATOM   1035 C CD1 . ILE A 1 132 ? -25.78831 3.53326   -1.18254  1.000 16.07218 ? 121  ILE A CD1 1 
ATOM   1036 N N   . THR A 1 133 ? -31.68755 4.44458   -1.32790  1.000 24.85047 ? 122  THR A N   1 
ATOM   1037 C CA  . THR A 1 133 ? -32.84785 4.46979   -2.20424  1.000 20.95357 ? 122  THR A CA  1 
ATOM   1038 C C   . THR A 1 133 ? -32.53105 5.06945   -3.56886  1.000 25.69541 ? 122  THR A C   1 
ATOM   1039 O O   . THR A 1 133 ? -33.10376 4.63025   -4.56694  1.000 23.96975 ? 122  THR A O   1 
ATOM   1040 C CB  . THR A 1 133 ? -34.00281 5.22211   -1.53626  1.000 28.69106 ? 122  THR A CB  1 
ATOM   1041 O OG1 . THR A 1 133 ? -33.79012 6.62468   -1.66303  1.000 38.32699 ? 122  THR A OG1 1 
ATOM   1042 C CG2 . THR A 1 133 ? -34.08137 4.86129   -0.05968  1.000 23.79572 ? 122  THR A CG2 1 
ATOM   1043 N N   . ASN A 1 134 ? -31.61056 6.03287   -3.64972  1.000 22.75499 ? 123  ASN A N   1 
ATOM   1044 C CA  . ASN A 1 134 ? -31.33079 6.70995   -4.92059  1.000 27.17136 ? 123  ASN A CA  1 
ATOM   1045 C C   . ASN A 1 134 ? -30.13513 6.04430   -5.58746  1.000 25.51660 ? 123  ASN A C   1 
ATOM   1046 O O   . ASN A 1 134 ? -29.01545 6.56248   -5.59765  1.000 25.23563 ? 123  ASN A O   1 
ATOM   1047 C CB  . ASN A 1 134 ? -31.08142 8.19718   -4.70635  1.000 28.96596 ? 123  ASN A CB  1 
ATOM   1048 C CG  . ASN A 1 134 ? -32.27884 8.91364   -4.11623  1.000 31.87363 ? 123  ASN A CG  1 
ATOM   1049 O OD1 . ASN A 1 134 ? -33.37326 8.35781   -4.03777  1.000 39.50310 ? 123  ASN A OD1 1 
ATOM   1050 N ND2 . ASN A 1 134 ? -32.07647 10.15878  -3.70375  1.000 36.58385 ? 123  ASN A ND2 1 
ATOM   1051 N N   . HIS A 1 135 ? -30.38145 4.87176   -6.16654  1.000 24.14712 ? 124  HIS A N   1 
ATOM   1052 C CA  . HIS A 1 135 ? -29.27773 4.15215   -6.78186  1.000 25.23985 ? 124  HIS A CA  1 
ATOM   1053 C C   . HIS A 1 135 ? -28.70960 4.88901   -7.98816  1.000 25.28231 ? 124  HIS A C   1 
ATOM   1054 O O   . HIS A 1 135 ? -27.58583 4.58648   -8.40138  1.000 25.12257 ? 124  HIS A O   1 
ATOM   1055 C CB  . HIS A 1 135 ? -29.71051 2.72731   -7.14107  1.000 25.05357 ? 124  HIS A CB  1 
ATOM   1056 C CG  . HIS A 1 135 ? -30.92148 2.65562   -8.01454  1.000 30.13822 ? 124  HIS A CG  1 
ATOM   1057 N ND1 . HIS A 1 135 ? -30.86430 2.78612   -9.38510  1.000 32.56850 ? 124  HIS A ND1 1 
ATOM   1058 C CD2 . HIS A 1 135 ? -32.22447 2.45033   -7.70948  1.000 30.27597 ? 124  HIS A CD2 1 
ATOM   1059 C CE1 . HIS A 1 135 ? -32.08104 2.67099   -9.88705  1.000 31.63664 ? 124  HIS A CE1 1 
ATOM   1060 N NE2 . HIS A 1 135 ? -32.92354 2.46123   -8.89135  1.000 31.82026 ? 124  HIS A NE2 1 
ATOM   1061 N N   . ASP A 1 136 ? -29.43663 5.87923   -8.52112  1.000 27.89233 ? 125  ASP A N   1 
ATOM   1062 C CA  A ASP A 1 136 ? -28.96318 6.68010   -9.64258  0.465 25.62457 ? 125  ASP A CA  1 
ATOM   1063 C CA  B ASP A 1 136 ? -28.96052 6.67930   -9.64638  0.535 25.61605 ? 125  ASP A CA  1 
ATOM   1064 C C   . ASP A 1 136 ? -27.86192 7.65948   -9.24966  1.000 20.99717 ? 125  ASP A C   1 
ATOM   1065 O O   . ASP A 1 136 ? -27.26467 8.28867   -10.12963 1.000 21.40271 ? 125  ASP A O   1 
ATOM   1066 C CB  A ASP A 1 136 ? -30.15123 7.41100   -10.28107 0.465 28.86393 ? 125  ASP A CB  1 
ATOM   1067 C CB  B ASP A 1 136 ? -30.12319 7.44783   -10.28667 0.535 28.86711 ? 125  ASP A CB  1 
ATOM   1068 C CG  A ASP A 1 136 ? -30.69336 8.53851   -9.41295  0.465 27.85782 ? 125  ASP A CG  1 
ATOM   1069 C CG  B ASP A 1 136 ? -30.98401 6.57903   -11.19909 0.535 30.91164 ? 125  ASP A CG  1 
ATOM   1070 O OD1 A ASP A 1 136 ? -30.48466 8.51168   -8.18296  0.465 32.03709 ? 125  ASP A OD1 1 
ATOM   1071 O OD1 B ASP A 1 136 ? -30.44091 5.90502   -12.10118 0.535 29.92634 ? 125  ASP A OD1 1 
ATOM   1072 O OD2 A ASP A 1 136 ? -31.34457 9.45288   -9.96269  0.465 34.69971 ? 125  ASP A OD2 1 
ATOM   1073 O OD2 B ASP A 1 136 ? -32.21903 6.58292   -11.01899 0.535 36.31378 ? 125  ASP A OD2 1 
ATOM   1074 N N   . GLU A 1 137 ? -27.56972 7.80472   -7.96931  1.000 20.51710 ? 126  GLU A N   1 
ATOM   1075 C CA  . GLU A 1 137 ? -26.41256 8.59327   -7.56645  1.000 20.60997 ? 126  GLU A CA  1 
ATOM   1076 C C   . GLU A 1 137 ? -25.13165 7.77344   -7.54692  1.000 19.43542 ? 126  GLU A C   1 
ATOM   1077 O O   . GLU A 1 137 ? -24.07985 8.32582   -7.20018  1.000 19.38925 ? 126  GLU A O   1 
ATOM   1078 C CB  . GLU A 1 137 ? -26.63874 9.22845   -6.18651  1.000 21.99119 ? 126  GLU A CB  1 
ATOM   1079 C CG  . GLU A 1 137 ? -27.96805 9.93207   -6.06600  1.000 25.90110 ? 126  GLU A CG  1 
ATOM   1080 C CD  . GLU A 1 137 ? -28.21137 10.51719  -4.68501  1.000 31.42328 ? 126  GLU A CD  1 
ATOM   1081 O OE1 . GLU A 1 137 ? -27.40572 10.25401  -3.75700  1.000 25.91083 ? 126  GLU A OE1 1 
ATOM   1082 O OE2 . GLU A 1 137 ? -29.22690 11.22801  -4.53151  1.000 29.22005 ? 126  GLU A OE2 1 
ATOM   1083 N N   . TYR A 1 138 ? -25.19650 6.48475   -7.92333  1.000 21.64902 ? 127  TYR A N   1 
ATOM   1084 C CA  . TYR A 1 138 ? -24.09661 5.53332   -7.78090  1.000 17.76365 ? 127  TYR A CA  1 
ATOM   1085 C C   . TYR A 1 138 ? -23.89551 4.73408   -9.06313  1.000 21.01178 ? 127  TYR A C   1 
ATOM   1086 O O   . TYR A 1 138 ? -24.76659 4.65877   -9.93130  1.000 17.14315 ? 127  TYR A O   1 
ATOM   1087 C CB  . TYR A 1 138 ? -24.33810 4.55758   -6.60035  1.000 17.90679 ? 127  TYR A CB  1 
ATOM   1088 C CG  . TYR A 1 138 ? -24.30157 5.29301   -5.29948  1.000 18.14748 ? 127  TYR A CG  1 
ATOM   1089 C CD1 . TYR A 1 138 ? -25.45527 5.83852   -4.74825  1.000 19.63361 ? 127  TYR A CD1 1 
ATOM   1090 C CD2 . TYR A 1 138 ? -23.09967 5.51934   -4.65803  1.000 19.89615 ? 127  TYR A CD2 1 
ATOM   1091 C CE1 . TYR A 1 138 ? -25.40026 6.56888   -3.55349  1.000 17.91840 ? 127  TYR A CE1 1 
ATOM   1092 C CE2 . TYR A 1 138 ? -23.03819 6.24311   -3.47610  1.000 19.53492 ? 127  TYR A CE2 1 
ATOM   1093 C CZ  . TYR A 1 138 ? -24.18021 6.76097   -2.93325  1.000 15.74109 ? 127  TYR A CZ  1 
ATOM   1094 O OH  . TYR A 1 138 ? -24.06878 7.47556   -1.75704  1.000 19.95475 ? 127  TYR A OH  1 
ATOM   1095 N N   . SER A 1 139 ? -22.71733 4.13780   -9.17581  1.000 17.26813 ? 128  SER A N   1 
ATOM   1096 C CA  . SER A 1 139 ? -22.44577 3.22963   -10.27856 1.000 17.87483 ? 128  SER A CA  1 
ATOM   1097 C C   . SER A 1 139 ? -21.44434 2.19015   -9.80165  1.000 20.19234 ? 128  SER A C   1 
ATOM   1098 O O   . SER A 1 139 ? -20.74365 2.38929   -8.80737  1.000 15.45571 ? 128  SER A O   1 
ATOM   1099 C CB  . SER A 1 139 ? -21.94287 3.99995   -11.51003 1.000 18.80531 ? 128  SER A CB  1 
ATOM   1100 O OG  . SER A 1 139 ? -20.57462 4.33590   -11.37719 1.000 23.05155 ? 128  SER A OG  1 
ATOM   1101 N N   . LEU A 1 140 ? -21.38170 1.07520   -10.52319 1.000 15.84286 ? 129  LEU A N   1 
ATOM   1102 C CA  . LEU A 1 140 ? -20.37448 0.05275   -10.27801 1.000 16.18013 ? 129  LEU A CA  1 
ATOM   1103 C C   . LEU A 1 140 ? -19.24107 0.21385   -11.28321 1.000 13.80834 ? 129  LEU A C   1 
ATOM   1104 O O   . LEU A 1 140 ? -19.48203 0.48569   -12.46327 1.000 13.91994 ? 129  LEU A O   1 
ATOM   1105 C CB  . LEU A 1 140 ? -20.97911 -1.34936  -10.39784 1.000 12.80613 ? 129  LEU A CB  1 
ATOM   1106 C CG  . LEU A 1 140 ? -22.05942 -1.72599  -9.38709  1.000 12.57546 ? 129  LEU A CG  1 
ATOM   1107 C CD1 . LEU A 1 140 ? -22.50816 -3.18518  -9.58585  1.000 13.70631 ? 129  LEU A CD1 1 
ATOM   1108 C CD2 . LEU A 1 140 ? -21.56799 -1.52598  -7.94447  1.000 15.02340 ? 129  LEU A CD2 1 
ATOM   1109 N N   . VAL A 1 141 ? -18.00964 0.03811   -10.81330 1.000 11.52325 ? 130  VAL A N   1 
ATOM   1110 C CA  . VAL A 1 141 ? -16.83091 0.13221   -11.66806 1.000 13.62724 ? 130  VAL A CA  1 
ATOM   1111 C C   . VAL A 1 141 ? -15.89164 -1.00902  -11.30067 1.000 14.06828 ? 130  VAL A C   1 
ATOM   1112 O O   . VAL A 1 141 ? -15.92400 -1.53470  -10.18166 1.000 15.73002 ? 130  VAL A O   1 
ATOM   1113 C CB  . VAL A 1 141 ? -16.10175 1.49187   -11.53164 1.000 16.46825 ? 130  VAL A CB  1 
ATOM   1114 C CG1 . VAL A 1 141 ? -16.84384 2.58702   -12.29922 1.000 22.30829 ? 130  VAL A CG1 1 
ATOM   1115 C CG2 . VAL A 1 141 ? -15.89939 1.84565   -10.09219 1.000 18.97363 ? 130  VAL A CG2 1 
ATOM   1116 N N   . ARG A 1 142 ? -15.07098 -1.41557  -12.26349 1.000 16.83820 ? 131  ARG A N   1 
ATOM   1117 C CA  . ARG A 1 142 ? -14.00814 -2.35294  -11.95176 1.000 13.44221 ? 131  ARG A CA  1 
ATOM   1118 C C   . ARG A 1 142 ? -12.86842 -1.63106  -11.22453 1.000 19.43987 ? 131  ARG A C   1 
ATOM   1119 O O   . ARG A 1 142 ? -12.81013 -0.39151  -11.15541 1.000 18.55459 ? 131  ARG A O   1 
ATOM   1120 C CB  . ARG A 1 142 ? -13.50407 -3.03732  -13.22596 1.000 12.91040 ? 131  ARG A CB  1 
ATOM   1121 C CG  . ARG A 1 142 ? -14.63406 -3.60396  -14.10469 1.000 15.29037 ? 131  ARG A CG  1 
ATOM   1122 C CD  . ARG A 1 142 ? -14.09110 -4.19234  -15.40834 1.000 15.27875 ? 131  ARG A CD  1 
ATOM   1123 N NE  . ARG A 1 142 ? -13.37145 -5.44123  -15.19254 1.000 17.30737 ? 131  ARG A NE  1 
ATOM   1124 C CZ  . ARG A 1 142 ? -13.03620 -6.27115  -16.17332 1.000 23.75184 ? 131  ARG A CZ  1 
ATOM   1125 N NH1 . ARG A 1 142 ? -13.18300 -5.92918  -17.44259 1.000 20.64091 ? 131  ARG A NH1 1 
ATOM   1126 N NH2 . ARG A 1 142 ? -12.54153 -7.46700  -15.87469 1.000 18.38028 ? 131  ARG A NH2 1 
ATOM   1127 N N   . GLU A 1 143 ? -11.96275 -2.43228  -10.66183 1.000 19.49274 ? 132  GLU A N   1 
ATOM   1128 C CA  . GLU A 1 143 ? -10.78993 -1.92311  -9.96077  1.000 24.58817 ? 132  GLU A CA  1 
ATOM   1129 C C   . GLU A 1 143 ? -9.51781  -2.44911  -10.61218 1.000 25.65811 ? 132  GLU A C   1 
ATOM   1130 O O   . GLU A 1 143 ? -8.61598  -2.93228  -9.92081  1.000 33.84929 ? 132  GLU A O   1 
ATOM   1131 C CB  . GLU A 1 143 ? -10.80498 -2.34194  -8.48836  1.000 24.22003 ? 132  GLU A CB  1 
ATOM   1132 C CG  . GLU A 1 143 ? -12.09152 -2.09415  -7.73672  1.000 25.21769 ? 132  GLU A CG  1 
ATOM   1133 C CD  . GLU A 1 143 ? -11.93233 -2.37613  -6.24143  1.000 26.09973 ? 132  GLU A CD  1 
ATOM   1134 O OE1 . GLU A 1 143 ? -11.52005 -3.49485  -5.87648  1.000 24.69904 ? 132  GLU A OE1 1 
ATOM   1135 O OE2 . GLU A 1 143 ? -12.22083 -1.48293  -5.42868  1.000 24.82468 ? 132  GLU A OE2 1 
ATOM   1136 N N   . LEU A 1 144 ? -9.44470  -2.40451  -11.93240 1.000 25.43000 ? 133  LEU A N   1 
ATOM   1137 C CA  . LEU A 1 144 ? -8.22713  -2.81457  -12.61501 1.000 30.10232 ? 133  LEU A CA  1 
ATOM   1138 C C   . LEU A 1 144 ? -7.18921  -1.69880  -12.54719 1.000 35.69520 ? 133  LEU A C   1 
ATOM   1139 O O   . LEU A 1 144 ? -7.52121  -0.51499  -12.41730 1.000 36.96535 ? 133  LEU A O   1 
ATOM   1140 C CB  . LEU A 1 144 ? -8.51876  -3.16027  -14.07159 1.000 26.96018 ? 133  LEU A CB  1 
ATOM   1141 C CG  . LEU A 1 144 ? -9.59466  -4.22030  -14.31853 1.000 26.24832 ? 133  LEU A CG  1 
ATOM   1142 C CD1 . LEU A 1 144 ? -9.70552  -4.57434  -15.79197 1.000 27.76549 ? 133  LEU A CD1 1 
ATOM   1143 C CD2 . LEU A 1 144 ? -9.31811  -5.44998  -13.47638 1.000 32.23665 ? 133  LEU A CD2 1 
ATOM   1144 N N   . MET A 1 145 ? -5.92216  -2.08286  -12.63077 1.000 45.89490 ? 134  MET A N   1 
ATOM   1145 C CA  . MET A 1 145 ? -4.85436  -1.09106  -12.72998 1.000 48.09322 ? 134  MET A CA  1 
ATOM   1146 C C   . MET A 1 145 ? -4.80419  -0.54611  -14.15634 1.000 53.51562 ? 134  MET A C   1 
ATOM   1147 O O   . MET A 1 145 ? -4.41817  0.59958   -14.38570 1.000 63.21770 ? 134  MET A O   1 
ATOM   1148 C CB  . MET A 1 145 ? -3.50407  -1.69634  -12.33197 1.000 51.01985 ? 134  MET A CB  1 
ATOM   1149 N N   . ASP A 1 150 ? -8.38070  4.70615   -16.24886 1.000 39.64320 ? 169  ASP A N   1 
ATOM   1150 C CA  . ASP A 1 150 ? -8.30975  3.62312   -17.21302 1.000 46.38339 ? 169  ASP A CA  1 
ATOM   1151 C C   . ASP A 1 150 ? -9.69764  3.36403   -17.79658 1.000 45.87932 ? 169  ASP A C   1 
ATOM   1152 O O   . ASP A 1 150 ? -10.62751 3.03940   -17.05788 1.000 41.49539 ? 169  ASP A O   1 
ATOM   1153 C CB  . ASP A 1 150 ? -7.74024  2.34868   -16.59121 1.000 44.09294 ? 169  ASP A CB  1 
ATOM   1154 N N   . GLU A 1 151 ? -9.82585  3.50877   -19.11640 1.000 46.73262 ? 170  GLU A N   1 
ATOM   1155 C CA  . GLU A 1 151 ? -11.10189 3.22298   -19.74539 1.000 37.80818 ? 170  GLU A CA  1 
ATOM   1156 C C   . GLU A 1 151 ? -11.55866 1.79863   -19.50071 1.000 36.50943 ? 170  GLU A C   1 
ATOM   1157 O O   . GLU A 1 151 ? -12.72456 1.48809   -19.77025 1.000 42.03310 ? 170  GLU A O   1 
ATOM   1158 C CB  . GLU A 1 151 ? -11.00520 3.50773   -21.25829 1.000 35.32720 ? 170  GLU A CB  1 
ATOM   1159 C CG  . GLU A 1 151 ? -10.73774 2.32481   -22.15544 1.000 36.71091 ? 170  GLU A CG  1 
ATOM   1160 C CD  . GLU A 1 151 ? -10.69794 2.76856   -23.62949 1.000 40.15546 ? 170  GLU A CD  1 
ATOM   1161 O OE1 . GLU A 1 151 ? -11.52432 2.33526   -24.46607 1.000 35.23734 ? 170  GLU A OE1 1 
ATOM   1162 O OE2 . GLU A 1 151 ? -9.80708  3.57668   -23.94310 1.000 41.95649 ? 170  GLU A OE2 1 
ATOM   1163 N N   . LEU A 1 152 ? -10.70356 0.97083   -18.91923 1.000 35.38384 ? 171  LEU A N   1 
ATOM   1164 C CA  . LEU A 1 152 ? -11.01919 -0.42842  -18.68822 1.000 33.32202 ? 171  LEU A CA  1 
ATOM   1165 C C   . LEU A 1 152 ? -11.93627 -0.63653  -17.49020 1.000 23.18975 ? 171  LEU A C   1 
ATOM   1166 O O   . LEU A 1 152 ? -12.57461 -1.68764  -17.39611 1.000 22.47528 ? 171  LEU A O   1 
ATOM   1167 C CB  . LEU A 1 152 ? -9.71597  -1.21254  -18.48202 1.000 39.61777 ? 171  LEU A CB  1 
ATOM   1168 C CG  . LEU A 1 152 ? -8.79605  -1.09000  -19.69743 1.000 39.61064 ? 171  LEU A CG  1 
ATOM   1169 C CD1 . LEU A 1 152 ? -7.48884  -1.81886  -19.45968 1.000 44.02828 ? 171  LEU A CD1 1 
ATOM   1170 C CD2 . LEU A 1 152 ? -9.52492  -1.62037  -20.92934 1.000 41.87697 ? 171  LEU A CD2 1 
ATOM   1171 N N   . ASN A 1 153 ? -12.03681 0.32471   -16.57976 1.000 22.40598 ? 172  ASN A N   1 
ATOM   1172 C CA  . ASN A 1 153 ? -12.86073 0.06649   -15.40638 1.000 19.89296 ? 172  ASN A CA  1 
ATOM   1173 C C   . ASN A 1 153 ? -14.32557 0.41472   -15.60351 1.000 24.39941 ? 172  ASN A C   1 
ATOM   1174 O O   . ASN A 1 153 ? -15.14816 0.05246   -14.75319 1.000 16.73277 ? 172  ASN A O   1 
ATOM   1175 C CB  . ASN A 1 153 ? -12.30405 0.80021   -14.19101 1.000 25.49764 ? 172  ASN A CB  1 
ATOM   1176 C CG  . ASN A 1 153 ? -10.98490 0.22037   -13.73704 1.000 28.12578 ? 172  ASN A CG  1 
ATOM   1177 O OD1 . ASN A 1 153 ? -10.75968 -0.98949  -13.85138 1.000 25.45603 ? 172  ASN A OD1 1 
ATOM   1178 N ND2 . ASN A 1 153 ? -10.09763 1.07557   -13.23611 1.000 29.47057 ? 172  ASN A ND2 1 
ATOM   1179 N N   . TRP A 1 154 ? -14.68050 1.07663   -16.70216 1.000 21.62205 ? 173  TRP A N   1 
ATOM   1180 C CA  . TRP A 1 154 ? -16.07197 1.44424   -16.92537 1.000 20.24318 ? 173  TRP A CA  1 
ATOM   1181 C C   . TRP A 1 154 ? -16.92013 0.20949   -17.21313 1.000 18.23986 ? 173  TRP A C   1 
ATOM   1182 O O   . TRP A 1 154 ? -16.50630 -0.68766  -17.95190 1.000 15.91790 ? 173  TRP A O   1 
ATOM   1183 C CB  . TRP A 1 154 ? -16.17672 2.41517   -18.10290 1.000 20.84926 ? 173  TRP A CB  1 
ATOM   1184 C CG  . TRP A 1 154 ? -17.56236 2.90394   -18.37666 1.000 20.01650 ? 173  TRP A CG  1 
ATOM   1185 C CD1 . TRP A 1 154 ? -18.23912 3.86814   -17.68681 1.000 22.60000 ? 173  TRP A CD1 1 
ATOM   1186 C CD2 . TRP A 1 154 ? -18.43974 2.46862   -19.42098 1.000 19.04374 ? 173  TRP A CD2 1 
ATOM   1187 N NE1 . TRP A 1 154 ? -19.47712 4.06041   -18.23570 1.000 23.50734 ? 173  TRP A NE1 1 
ATOM   1188 C CE2 . TRP A 1 154 ? -19.62602 3.21983   -19.30530 1.000 19.13332 ? 173  TRP A CE2 1 
ATOM   1189 C CE3 . TRP A 1 154 ? -18.32655 1.53980   -20.46017 1.000 20.09516 ? 173  TRP A CE3 1 
ATOM   1190 C CZ2 . TRP A 1 154 ? -20.70055 3.06053   -20.17802 1.000 20.28393 ? 173  TRP A CZ2 1 
ATOM   1191 C CZ3 . TRP A 1 154 ? -19.40091 1.37301   -21.31724 1.000 17.75474 ? 173  TRP A CZ3 1 
ATOM   1192 C CH2 . TRP A 1 154 ? -20.56707 2.13732   -21.17429 1.000 18.64453 ? 173  TRP A CH2 1 
ATOM   1193 N N   . LEU A 1 155 ? -18.13774 0.19902   -16.66876 1.000 16.76212 ? 174  LEU A N   1 
ATOM   1194 C CA  . LEU A 1 155 ? -19.11549 -0.84979  -16.93823 1.000 17.93867 ? 174  LEU A CA  1 
ATOM   1195 C C   . LEU A 1 155 ? -20.37920 -0.22154  -17.51072 1.000 16.94561 ? 174  LEU A C   1 
ATOM   1196 O O   . LEU A 1 155 ? -20.90521 0.74642   -16.95333 1.000 20.28510 ? 174  LEU A O   1 
ATOM   1197 C CB  . LEU A 1 155 ? -19.45976 -1.62239  -15.66552 1.000 13.70349 ? 174  LEU A CB  1 
ATOM   1198 C CG  . LEU A 1 155 ? -18.35421 -2.52857  -15.12570 1.000 15.68131 ? 174  LEU A CG  1 
ATOM   1199 C CD1 . LEU A 1 155 ? -18.75047 -2.94403  -13.71579 1.000 13.35022 ? 174  LEU A CD1 1 
ATOM   1200 C CD2 . LEU A 1 155 ? -18.14164 -3.72085  -16.05572 1.000 17.05316 ? 174  LEU A CD2 1 
ATOM   1201 N N   . ASP A 1 156 ? -20.84133 -0.75668  -18.63042 1.000 16.32977 ? 175  ASP A N   1 
ATOM   1202 C CA  . ASP A 1 156 ? -22.14557 -0.41245  -19.18643 1.000 17.77015 ? 175  ASP A CA  1 
ATOM   1203 C C   . ASP A 1 156 ? -23.20813 -1.04493  -18.30911 1.000 16.96817 ? 175  ASP A C   1 
ATOM   1204 O O   . ASP A 1 156 ? -23.28684 -2.27519  -18.21736 1.000 16.22126 ? 175  ASP A O   1 
ATOM   1205 C CB  . ASP A 1 156 ? -22.23776 -0.92780  -20.61912 1.000 16.67268 ? 175  ASP A CB  1 
ATOM   1206 C CG  . ASP A 1 156 ? -23.43620 -0.39131  -21.38008 1.000 18.73226 ? 175  ASP A CG  1 
ATOM   1207 O OD1 . ASP A 1 156 ? -24.41458 0.05958   -20.75248 1.000 21.35211 ? 175  ASP A OD1 1 
ATOM   1208 O OD2 . ASP A 1 156 ? -23.40542 -0.47202  -22.62759 1.000 17.99758 ? 175  ASP A OD2 1 
ATOM   1209 N N   . HIS A 1 157 ? -24.00980 -0.21754  -17.63453 1.000 15.44270 ? 176  HIS A N   1 
ATOM   1210 C CA  . HIS A 1 157 ? -24.98811 -0.77820  -16.71014 1.000 15.45253 ? 176  HIS A CA  1 
ATOM   1211 C C   . HIS A 1 157 ? -26.18206 -1.39840  -17.42960 1.000 19.01337 ? 176  HIS A C   1 
ATOM   1212 O O   . HIS A 1 157 ? -26.94129 -2.15849  -16.81208 1.000 18.06443 ? 176  HIS A O   1 
ATOM   1213 C CB  . HIS A 1 157 ? -25.40348 0.30656   -15.71529 1.000 19.62659 ? 176  HIS A CB  1 
ATOM   1214 C CG  . HIS A 1 157 ? -24.39980 0.50390   -14.61878 1.000 19.68107 ? 176  HIS A CG  1 
ATOM   1215 N ND1 . HIS A 1 157 ? -23.06046 0.73404   -14.87093 1.000 17.76596 ? 176  HIS A ND1 1 
ATOM   1216 C CD2 . HIS A 1 157 ? -24.53142 0.47922   -13.26913 1.000 21.70937 ? 176  HIS A CD2 1 
ATOM   1217 C CE1 . HIS A 1 157 ? -22.41398 0.85824   -13.72379 1.000 19.92379 ? 176  HIS A CE1 1 
ATOM   1218 N NE2 . HIS A 1 157 ? -23.28301 0.70979   -12.73650 1.000 20.38057 ? 176  HIS A NE2 1 
ATOM   1219 N N   . GLY A 1 158 ? -26.33439 -1.14449  -18.72663 1.000 15.86171 ? 177  GLY A N   1 
ATOM   1220 C CA  . GLY A 1 158 ? -27.37378 -1.81610  -19.47880 1.000 17.76045 ? 177  GLY A CA  1 
ATOM   1221 C C   . GLY A 1 158 ? -26.99500 -3.19315  -19.98525 1.000 19.32797 ? 177  GLY A C   1 
ATOM   1222 O O   . GLY A 1 158 ? -27.84337 -3.88986  -20.54841 1.000 19.43326 ? 177  GLY A O   1 
ATOM   1223 N N   . ARG A 1 159 ? -25.75711 -3.61158  -19.77049 1.000 16.32855 ? 178  ARG A N   1 
ATOM   1224 C CA  . ARG A 1 159 ? -25.27794 -4.92272  -20.18490 1.000 11.85485 ? 178  ARG A CA  1 
ATOM   1225 C C   . ARG A 1 159 ? -24.95652 -5.74786  -18.94372 1.000 16.32092 ? 178  ARG A C   1 
ATOM   1226 O O   . ARG A 1 159 ? -25.06694 -5.26608  -17.81176 1.000 15.13587 ? 178  ARG A O   1 
ATOM   1227 C CB  . ARG A 1 159 ? -24.07415 -4.76243  -21.11183 1.000 15.61156 ? 178  ARG A CB  1 
ATOM   1228 C CG  . ARG A 1 159 ? -24.49672 -4.14434  -22.46531 1.000 24.05701 ? 178  ARG A CG  1 
ATOM   1229 C CD  . ARG A 1 159 ? -23.31846 -3.71035  -23.32390 1.000 25.93981 ? 178  ARG A CD  1 
ATOM   1230 N NE  . ARG A 1 159 ? -22.61275 -4.83866  -23.91358 1.000 30.42190 ? 178  ARG A NE  1 
ATOM   1231 C CZ  . ARG A 1 159 ? -21.29236 -4.90882  -24.02527 1.000 35.06586 ? 178  ARG A CZ  1 
ATOM   1232 N NH1 . ARG A 1 159 ? -20.51172 -3.90720  -23.64153 1.000 32.76925 ? 178  ARG A NH1 1 
ATOM   1233 N NH2 . ARG A 1 159 ? -20.74391 -5.99794  -24.55429 1.000 30.37742 ? 178  ARG A NH2 1 
ATOM   1234 N N   . THR A 1 160 ? -24.59597 -7.01421  -19.15523 1.000 14.02187 ? 179  THR A N   1 
ATOM   1235 C CA  . THR A 1 160 ? -24.25706 -7.85973  -18.01869 1.000 12.82719 ? 179  THR A CA  1 
ATOM   1236 C C   . THR A 1 160 ? -22.77277 -7.75961  -17.69436 1.000 11.95361 ? 179  THR A C   1 
ATOM   1237 O O   . THR A 1 160 ? -21.94747 -7.37361  -18.52029 1.000 11.28646 ? 179  THR A O   1 
ATOM   1238 C CB  . THR A 1 160 ? -24.62793 -9.32831  -18.27306 1.000 13.21338 ? 179  THR A CB  1 
ATOM   1239 O OG1 . THR A 1 160 ? -23.77260 -9.86704  -19.28647 1.000 12.99419 ? 179  THR A OG1 1 
ATOM   1240 C CG2 . THR A 1 160 ? -26.09741 -9.49093  -18.69554 1.000 12.56397 ? 179  THR A CG2 1 
ATOM   1241 N N   . LEU A 1 161 ? -22.43554 -8.10861  -16.45066 1.000 9.60847  ? 180  LEU A N   1 
ATOM   1242 C CA  . LEU A 1 161 ? -21.03227 -8.26903  -16.10449 1.000 11.70070 ? 180  LEU A CA  1 
ATOM   1243 C C   . LEU A 1 161 ? -20.38097 -9.32855  -16.98521 1.000 13.08785 ? 180  LEU A C   1 
ATOM   1244 O O   . LEU A 1 161 ? -19.28227 -9.12438  -17.52206 1.000 13.73022 ? 180  LEU A O   1 
ATOM   1245 C CB  . LEU A 1 161 ? -20.91003 -8.67646  -14.64024 1.000 11.23340 ? 180  LEU A CB  1 
ATOM   1246 C CG  . LEU A 1 161 ? -21.25874 -7.59430  -13.61400 1.000 13.62432 ? 180  LEU A CG  1 
ATOM   1247 C CD1 . LEU A 1 161 ? -21.15179 -8.20868  -12.21233 1.000 13.33012 ? 180  LEU A CD1 1 
ATOM   1248 C CD2 . LEU A 1 161 ? -20.31837 -6.40581  -13.73441 1.000 13.07512 ? 180  LEU A CD2 1 
ATOM   1249 N N   . ARG A 1 162 ? -21.06015 -10.47046 -17.13728 1.000 10.23003 ? 181  ARG A N   1 
ATOM   1250 C CA  . ARG A 1 162 ? -20.52050 -11.60896 -17.87371 1.000 13.19268 ? 181  ARG A CA  1 
ATOM   1251 C C   . ARG A 1 162 ? -20.08028 -11.20751 -19.27496 1.000 13.55565 ? 181  ARG A C   1 
ATOM   1252 O O   . ARG A 1 162 ? -18.95748 -11.50173 -19.69473 1.000 15.01017 ? 181  ARG A O   1 
ATOM   1253 C CB  . ARG A 1 162 ? -21.58349 -12.71296 -17.96087 1.000 11.22161 ? 181  ARG A CB  1 
ATOM   1254 C CG  . ARG A 1 162 ? -21.16847 -13.91660 -18.78625 1.000 15.63628 ? 181  ARG A CG  1 
ATOM   1255 C CD  . ARG A 1 162 ? -22.05056 -15.12985 -18.46933 1.000 14.04344 ? 181  ARG A CD  1 
ATOM   1256 N NE  . ARG A 1 162 ? -21.71390 -15.65491 -17.15088 1.000 14.54548 ? 181  ARG A NE  1 
ATOM   1257 C CZ  . ARG A 1 162 ? -22.50149 -15.55944 -16.08882 1.000 17.74317 ? 181  ARG A CZ  1 
ATOM   1258 N NH1 . ARG A 1 162 ? -23.70057 -15.00040 -16.17037 1.000 12.84127 ? 181  ARG A NH1 1 
ATOM   1259 N NH2 . ARG A 1 162 ? -22.06246 -16.00739 -14.91289 1.000 14.79633 ? 181  ARG A NH2 1 
ATOM   1260 N N   . GLU A 1 163 ? -20.94761 -10.51977 -20.01115 1.000 12.74012 ? 182  GLU A N   1 
ATOM   1261 C CA  . GLU A 1 163 ? -20.60845 -10.25349 -21.40535 1.000 13.32885 ? 182  GLU A CA  1 
ATOM   1262 C C   . GLU A 1 163 ? -19.54781 -9.16845  -21.53338 1.000 16.91195 ? 182  GLU A C   1 
ATOM   1263 O O   . GLU A 1 163 ? -18.95158 -9.01115  -22.60753 1.000 16.49963 ? 182  GLU A O   1 
ATOM   1264 C CB  . GLU A 1 163 ? -21.87225 -9.88259  -22.19001 1.000 16.30263 ? 182  GLU A CB  1 
ATOM   1265 C CG  . GLU A 1 163 ? -22.44918 -8.52334  -21.84243 1.000 15.57652 ? 182  GLU A CG  1 
ATOM   1266 C CD  . GLU A 1 163 ? -23.79495 -8.26672  -22.49824 1.000 21.88390 ? 182  GLU A CD  1 
ATOM   1267 O OE1 . GLU A 1 163 ? -23.87975 -8.37362  -23.73703 1.000 28.85572 ? 182  GLU A OE1 1 
ATOM   1268 O OE2 . GLU A 1 163 ? -24.74978 -7.89321  -21.79243 1.000 16.50221 ? 182  GLU A OE2 1 
ATOM   1269 N N   . GLN A 1 164 ? -19.28548 -8.43235  -20.46351 1.000 14.39285 ? 183  GLN A N   1 
ATOM   1270 C CA  . GLN A 1 164 ? -18.22857 -7.44297  -20.43347 1.000 13.90342 ? 183  GLN A CA  1 
ATOM   1271 C C   . GLN A 1 164 ? -16.93575 -8.02529  -19.89054 1.000 15.79553 ? 183  GLN A C   1 
ATOM   1272 O O   . GLN A 1 164 ? -15.97579 -7.28416  -19.65409 1.000 14.88632 ? 183  GLN A O   1 
ATOM   1273 C CB  . GLN A 1 164 ? -18.68873 -6.23861  -19.61594 1.000 13.94993 ? 183  GLN A CB  1 
ATOM   1274 C CG  . GLN A 1 164 ? -19.89974 -5.54320  -20.25005 1.000 16.67886 ? 183  GLN A CG  1 
ATOM   1275 C CD  . GLN A 1 164 ? -20.35877 -4.31063  -19.48391 1.000 18.38623 ? 183  GLN A CD  1 
ATOM   1276 O OE1 . GLN A 1 164 ? -19.77104 -3.22107  -19.60708 1.000 17.27355 ? 183  GLN A OE1 1 
ATOM   1277 N NE2 . GLN A 1 164 ? -21.42538 -4.47476  -18.67677 1.000 15.19714 ? 183  GLN A NE2 1 
ATOM   1278 N N   . GLY A 1 165 ? -16.89861 -9.33871  -19.68232 1.000 14.18427 ? 184  GLY A N   1 
ATOM   1279 C CA  . GLY A 1 165 ? -15.67273 -9.98971  -19.27961 1.000 18.52088 ? 184  GLY A CA  1 
ATOM   1280 C C   . GLY A 1 165 ? -15.39049 -9.96552  -17.79904 1.000 16.82147 ? 184  GLY A C   1 
ATOM   1281 O O   . GLY A 1 165 ? -14.25120 -10.21706 -17.39683 1.000 21.74491 ? 184  GLY A O   1 
ATOM   1282 N N   . VAL A 1 166 ? -16.38455 -9.66963  -16.96850 1.000 14.15433 ? 185  VAL A N   1 
ATOM   1283 C CA  . VAL A 1 166 ? -16.22299 -9.70366  -15.51975 1.000 15.10058 ? 185  VAL A CA  1 
ATOM   1284 C C   . VAL A 1 166 ? -16.72918 -11.04425 -15.02148 1.000 16.35406 ? 185  VAL A C   1 
ATOM   1285 O O   . VAL A 1 166 ? -17.92962 -11.34141 -15.10162 1.000 15.18120 ? 185  VAL A O   1 
ATOM   1286 C CB  . VAL A 1 166 ? -16.95156 -8.54132  -14.83606 1.000 15.05518 ? 185  VAL A CB  1 
ATOM   1287 C CG1 . VAL A 1 166 ? -16.83378 -8.65057  -13.31054 1.000 12.96739 ? 185  VAL A CG1 1 
ATOM   1288 C CG2 . VAL A 1 166 ? -16.34329 -7.24190  -15.31513 1.000 13.68232 ? 185  VAL A CG2 1 
ATOM   1289 N N   . GLU A 1 167 ? -15.80733 -11.85103 -14.50305 1.000 14.42705 ? 186  GLU A N   1 
ATOM   1290 C CA  . GLU A 1 167 ? -16.16791 -13.15531 -13.97043 1.000 17.09459 ? 186  GLU A CA  1 
ATOM   1291 C C   . GLU A 1 167 ? -16.46786 -13.04603 -12.47828 1.000 14.01816 ? 186  GLU A C   1 
ATOM   1292 O O   . GLU A 1 167 ? -16.32646 -11.98818 -11.85205 1.000 14.19038 ? 186  GLU A O   1 
ATOM   1293 C CB  . GLU A 1 167 ? -15.05417 -14.14976 -14.26789 1.000 15.76347 ? 186  GLU A CB  1 
ATOM   1294 C CG  . GLU A 1 167 ? -14.93694 -14.51293 -15.74840 1.000 16.68758 ? 186  GLU A CG  1 
ATOM   1295 C CD  . GLU A 1 167 ? -14.05936 -15.74730 -15.96061 1.000 20.41747 ? 186  GLU A CD  1 
ATOM   1296 O OE1 . GLU A 1 167 ? -12.82727 -15.59229 -15.81058 1.000 20.35600 ? 186  GLU A OE1 1 
ATOM   1297 O OE2 . GLU A 1 167 ? -14.56905 -16.84313 -16.28114 1.000 19.11705 ? 186  GLU A OE2 1 
ATOM   1298 N N   . GLU A 1 168 ? -16.88151 -14.17253 -11.89640 1.000 16.80605 ? 187  GLU A N   1 
ATOM   1299 C CA  . GLU A 1 168 ? -17.48532 -14.19298 -10.56854 1.000 16.12273 ? 187  GLU A CA  1 
ATOM   1300 C C   . GLU A 1 168 ? -16.49326 -13.86288 -9.45186  1.000 16.74179 ? 187  GLU A C   1 
ATOM   1301 O O   . GLU A 1 168 ? -16.90792 -13.38135 -8.38591  1.000 16.21777 ? 187  GLU A O   1 
ATOM   1302 C CB  . GLU A 1 168 ? -18.13422 -15.57222 -10.36544 1.000 19.03504 ? 187  GLU A CB  1 
ATOM   1303 C CG  . GLU A 1 168 ? -19.28041 -15.87683 -11.36896 1.000 18.88676 ? 187  GLU A CG  1 
ATOM   1304 C CD  . GLU A 1 168 ? -18.82499 -16.55708 -12.69287 1.000 20.95264 ? 187  GLU A CD  1 
ATOM   1305 O OE1 . GLU A 1 168 ? -17.63374 -16.49291 -13.06076 1.000 17.17428 ? 187  GLU A OE1 1 
ATOM   1306 O OE2 . GLU A 1 168 ? -19.67936 -17.13612 -13.39735 1.000 23.88935 ? 187  GLU A OE2 1 
ATOM   1307 N N   . HIS A 1 169 ? -15.19606 -14.09138 -9.67342  1.000 15.08953 ? 188  HIS A N   1 
ATOM   1308 C CA  . HIS A 1 169 ? -14.18057 -13.79751 -8.65887  1.000 15.35837 ? 188  HIS A CA  1 
ATOM   1309 C C   . HIS A 1 169 ? -13.95178 -12.29884 -8.45372  1.000 19.00436 ? 188  HIS A C   1 
ATOM   1310 O O   . HIS A 1 169 ? -13.37461 -11.90055 -7.43410  1.000 15.93651 ? 188  HIS A O   1 
ATOM   1311 C CB  . HIS A 1 169 ? -12.83289 -14.42522 -9.04378  1.000 16.42759 ? 188  HIS A CB  1 
ATOM   1312 C CG  . HIS A 1 169 ? -12.23019 -13.82472 -10.27591 1.000 14.83755 ? 188  HIS A CG  1 
ATOM   1313 N ND1 . HIS A 1 169 ? -11.39981 -12.72330 -10.23753 1.000 17.41294 ? 188  HIS A ND1 1 
ATOM   1314 C CD2 . HIS A 1 169 ? -12.34502 -14.16415 -11.58197 1.000 17.49852 ? 188  HIS A CD2 1 
ATOM   1315 C CE1 . HIS A 1 169 ? -11.03740 -12.40569 -11.46916 1.000 16.37511 ? 188  HIS A CE1 1 
ATOM   1316 N NE2 . HIS A 1 169 ? -11.59330 -13.26714 -12.30337 1.000 15.18402 ? 188  HIS A NE2 1 
ATOM   1317 N N   . GLU A 1 170 ? -14.36953 -11.45765 -9.39282  1.000 14.13674 ? 189  GLU A N   1 
ATOM   1318 C CA  . GLU A 1 170 ? -13.88694 -10.08333 -9.40676  1.000 14.96779 ? 189  GLU A CA  1 
ATOM   1319 C C   . GLU A 1 170 ? -14.70292 -9.19246  -8.47227  1.000 16.15317 ? 189  GLU A C   1 
ATOM   1320 O O   . GLU A 1 170 ? -15.93877 -9.17468  -8.52984  1.000 14.55982 ? 189  GLU A O   1 
ATOM   1321 C CB  . GLU A 1 170 ? -13.91989 -9.53117  -10.82690 1.000 16.15465 ? 189  GLU A CB  1 
ATOM   1322 C CG  . GLU A 1 170 ? -13.41490 -8.10023  -10.91699 1.000 16.80861 ? 189  GLU A CG  1 
ATOM   1323 C CD  . GLU A 1 170 ? -13.16397 -7.65350  -12.35544 1.000 18.35781 ? 189  GLU A CD  1 
ATOM   1324 O OE1 . GLU A 1 170 ? -13.17493 -8.50328  -13.28134 1.000 16.61922 ? 189  GLU A OE1 1 
ATOM   1325 O OE2 . GLU A 1 170 ? -12.97956 -6.43978  -12.55408 1.000 16.51768 ? 189  GLU A OE2 1 
ATOM   1326 N N   . THR A 1 171 ? -13.99577 -8.45603  -7.61385  1.000 13.16772 ? 190  THR A N   1 
ATOM   1327 C CA  . THR A 1 171 ? -14.59804 -7.45677  -6.73857  1.000 14.24473 ? 190  THR A CA  1 
ATOM   1328 C C   . THR A 1 171 ? -14.80274 -6.15224  -7.50621  1.000 14.98182 ? 190  THR A C   1 
ATOM   1329 O O   . THR A 1 171 ? -13.89621 -5.69750  -8.21643  1.000 15.28495 ? 190  THR A O   1 
ATOM   1330 C CB  . THR A 1 171 ? -13.68374 -7.21939  -5.53213  1.000 13.50750 ? 190  THR A CB  1 
ATOM   1331 O OG1 . THR A 1 171 ? -13.54950 -8.44178  -4.78408  1.000 14.03155 ? 190  THR A OG1 1 
ATOM   1332 C CG2 . THR A 1 171 ? -14.24868 -6.11988  -4.62509  1.000 13.72667 ? 190  THR A CG2 1 
ATOM   1333 N N   . LEU A 1 172 ? -15.98364 -5.54858  -7.36636  1.000 12.90773 ? 191  LEU A N   1 
ATOM   1334 C CA  . LEU A 1 172 ? -16.30412 -4.27993  -8.02219  1.000 11.33419 ? 191  LEU A CA  1 
ATOM   1335 C C   . LEU A 1 172 ? -16.37655 -3.18666  -6.96942  1.000 15.37725 ? 191  LEU A C   1 
ATOM   1336 O O   . LEU A 1 172 ? -16.52520 -3.46593  -5.77810  1.000 15.00901 ? 191  LEU A O   1 
ATOM   1337 C CB  . LEU A 1 172 ? -17.64521 -4.36117  -8.75710  1.000 11.57728 ? 191  LEU A CB  1 
ATOM   1338 C CG  . LEU A 1 172 ? -17.69599 -5.45436  -9.81463  1.000 10.67316 ? 191  LEU A CG  1 
ATOM   1339 C CD1 . LEU A 1 172 ? -19.07028 -5.51642  -10.45514 1.000 11.44276 ? 191  LEU A CD1 1 
ATOM   1340 C CD2 . LEU A 1 172 ? -16.62501 -5.18719  -10.88901 1.000 15.37252 ? 191  LEU A CD2 1 
ATOM   1341 N N   . LEU A 1 173 ? -16.31692 -1.93350  -7.41752  1.000 12.75156 ? 192  LEU A N   1 
ATOM   1342 C CA  . LEU A 1 173 ? -16.35867 -0.78288  -6.51778  1.000 15.26949 ? 192  LEU A CA  1 
ATOM   1343 C C   . LEU A 1 173 ? -17.69076 -0.05718  -6.66676  1.000 15.45210 ? 192  LEU A C   1 
ATOM   1344 O O   . LEU A 1 173 ? -18.11260 0.26054   -7.78210  1.000 14.72866 ? 192  LEU A O   1 
ATOM   1345 C CB  . LEU A 1 173 ? -15.19528 0.17110   -6.79512  1.000 17.10092 ? 192  LEU A CB  1 
ATOM   1346 C CG  . LEU A 1 173 ? -15.24848 1.56755   -6.15933  1.000 15.31248 ? 192  LEU A CG  1 
ATOM   1347 C CD1 . LEU A 1 173 ? -15.02058 1.44882   -4.64887  1.000 15.74999 ? 192  LEU A CD1 1 
ATOM   1348 C CD2 . LEU A 1 173 ? -14.20146 2.47057   -6.80624  1.000 17.46628 ? 192  LEU A CD2 1 
ATOM   1349 N N   . LEU A 1 174 ? -18.35452 0.19164   -5.54489  1.000 12.03253 ? 193  LEU A N   1 
ATOM   1350 C CA  . LEU A 1 174 ? -19.51549 1.07035   -5.53001  1.000 11.97233 ? 193  LEU A CA  1 
ATOM   1351 C C   . LEU A 1 174 ? -19.02171 2.51206   -5.44898  1.000 16.64158 ? 193  LEU A C   1 
ATOM   1352 O O   . LEU A 1 174 ? -18.33435 2.87592   -4.49509  1.000 14.83495 ? 193  LEU A O   1 
ATOM   1353 C CB  . LEU A 1 174 ? -20.41638 0.72203   -4.34564  1.000 13.15484 ? 193  LEU A CB  1 
ATOM   1354 C CG  . LEU A 1 174 ? -21.63234 1.61034   -4.16442  1.000 14.36090 ? 193  LEU A CG  1 
ATOM   1355 C CD1 . LEU A 1 174 ? -22.60415 1.38712   -5.32016  1.000 13.57550 ? 193  LEU A CD1 1 
ATOM   1356 C CD2 . LEU A 1 174 ? -22.29916 1.27627   -2.79538  1.000 13.14746 ? 193  LEU A CD2 1 
ATOM   1357 N N   . ARG A 1 175 ? -19.34251 3.33157   -6.44862  1.000 15.69238 ? 194  ARG A N   1 
ATOM   1358 C CA  . ARG A 1 175 ? -18.75398 4.66634   -6.52971  1.000 16.94824 ? 194  ARG A CA  1 
ATOM   1359 C C   . ARG A 1 175 ? -19.83615 5.72374   -6.60281  1.000 17.53716 ? 194  ARG A C   1 
ATOM   1360 O O   . ARG A 1 175 ? -20.71656 5.64403   -7.46529  1.000 15.26944 ? 194  ARG A O   1 
ATOM   1361 C CB  . ARG A 1 175 ? -17.84540 4.81275   -7.74636  1.000 17.21241 ? 194  ARG A CB  1 
ATOM   1362 C CG  . ARG A 1 175 ? -17.07035 6.11887   -7.70236  1.000 25.48426 ? 194  ARG A CG  1 
ATOM   1363 C CD  . ARG A 1 175 ? -16.30073 6.39278   -9.00266  1.000 26.96213 ? 194  ARG A CD  1 
ATOM   1364 N NE  . ARG A 1 175 ? -14.94200 5.88681   -8.89306  1.000 30.03185 ? 194  ARG A NE  1 
ATOM   1365 C CZ  . ARG A 1 175 ? -14.19325 5.50881   -9.92097  1.000 35.28978 ? 194  ARG A CZ  1 
ATOM   1366 N NH1 . ARG A 1 175 ? -14.57629 5.72684   -11.17381 1.000 26.21710 ? 194  ARG A NH1 1 
ATOM   1367 N NH2 . ARG A 1 175 ? -13.03097 4.89940   -9.68502  1.000 31.14783 ? 194  ARG A NH2 1 
ATOM   1368 N N   . ARG A 1 176 ? -19.76158 6.71714   -5.71205  1.000 17.09167 ? 195  ARG A N   1 
ATOM   1369 C CA  . ARG A 1 176 ? -20.69069 7.84468   -5.78699  1.000 20.70602 ? 195  ARG A CA  1 
ATOM   1370 C C   . ARG A 1 176 ? -20.34973 8.73820   -6.96796  1.000 19.60451 ? 195  ARG A C   1 
ATOM   1371 O O   . ARG A 1 176 ? -19.18577 9.10960   -7.16605  1.000 17.52991 ? 195  ARG A O   1 
ATOM   1372 C CB  . ARG A 1 176 ? -20.67284 8.67168   -4.49201  1.000 21.83100 ? 195  ARG A CB  1 
ATOM   1373 C CG  . ARG A 1 176 ? -21.87026 9.63528   -4.34953  1.000 20.88329 ? 195  ARG A CG  1 
ATOM   1374 C CD  . ARG A 1 176 ? -21.89351 10.33070  -2.95198  1.000 23.35936 ? 195  ARG A CD  1 
ATOM   1375 N NE  . ARG A 1 176 ? -22.75141 11.51650  -2.91709  1.000 25.90716 ? 195  ARG A NE  1 
ATOM   1376 C CZ  . ARG A 1 176 ? -24.07645 11.51303  -3.04183  1.000 27.45549 ? 195  ARG A CZ  1 
ATOM   1377 N NH1 . ARG A 1 176 ? -24.76430 10.38479  -3.10296  1.000 25.31186 ? 195  ARG A NH1 1 
ATOM   1378 N NH2 . ARG A 1 176 ? -24.72726 12.67521  -3.11516  1.000 24.93583 ? 195  ARG A NH2 1 
ATOM   1379 N N   . LYS A 1 177 ? -21.36320 9.10566   -7.74016  1.000 17.26697 ? 196  LYS A N   1 
ATOM   1380 C CA  . LYS A 1 177 ? -21.11064 10.03656  -8.82889  1.000 20.58372 ? 196  LYS A CA  1 
ATOM   1381 C C   . LYS A 1 177 ? -20.75025 11.41267  -8.27584  1.000 26.55627 ? 196  LYS A C   1 
ATOM   1382 O O   . LYS A 1 177 ? -20.97202 11.72289  -7.09641  1.000 20.20449 ? 196  LYS A O   1 
ATOM   1383 C CB  . LYS A 1 177 ? -22.31722 10.12068  -9.75957  1.000 22.19125 ? 196  LYS A CB  1 
ATOM   1384 C CG  . LYS A 1 177 ? -22.76773 8.77781   -10.30032 1.000 19.08458 ? 196  LYS A CG  1 
ATOM   1385 C CD  . LYS A 1 177 ? -23.87863 8.98425   -11.33554 1.000 23.22890 ? 196  LYS A CD  1 
ATOM   1386 C CE  . LYS A 1 177 ? -24.27780 7.69152   -12.03786 1.000 23.24119 ? 196  LYS A CE  1 
ATOM   1387 N NZ  . LYS A 1 177 ? -25.72243 7.70811   -12.47785 1.000 23.81845 ? 196  LYS A NZ  1 
ATOM   1388 N N   . PHE A 1 178 ? -20.16002 12.23889  -9.14020  1.000 22.33645 ? 197  PHE A N   1 
ATOM   1389 C CA  . PHE A 1 178 ? -19.76980 13.58144  -8.72919  1.000 19.38552 ? 197  PHE A CA  1 
ATOM   1390 C C   . PHE A 1 178 ? -20.98988 14.49154  -8.63577  1.000 20.58438 ? 197  PHE A C   1 
ATOM   1391 O O   . PHE A 1 178 ? -21.78761 14.57585  -9.57672  1.000 21.28023 ? 197  PHE A O   1 
ATOM   1392 C CB  . PHE A 1 178 ? -18.76299 14.18685  -9.70553  1.000 19.28187 ? 197  PHE A CB  1 
ATOM   1393 C CG  . PHE A 1 178 ? -18.31037 15.56346  -9.29029  1.000 22.28076 ? 197  PHE A CG  1 
ATOM   1394 C CD1 . PHE A 1 178 ? -17.24068 15.71958  -8.42153  1.000 25.36667 ? 197  PHE A CD1 1 
ATOM   1395 C CD2 . PHE A 1 178 ? -19.01426 16.69132  -9.68571  1.000 24.91469 ? 197  PHE A CD2 1 
ATOM   1396 C CE1 . PHE A 1 178 ? -16.84692 16.97337  -8.00781  1.000 26.03195 ? 197  PHE A CE1 1 
ATOM   1397 C CE2 . PHE A 1 178 ? -18.63251 17.94782  -9.26154  1.000 26.30549 ? 197  PHE A CE2 1 
ATOM   1398 C CZ  . PHE A 1 178 ? -17.54390 18.08537  -8.41920  1.000 23.10037 ? 197  PHE A CZ  1 
ATOM   1399 N N   . PHE A 1 179 ? -21.11011 15.20678  -7.51605  1.000 20.60203 ? 198  PHE A N   1 
ATOM   1400 C CA  . PHE A 1 179 ? -22.12360 16.24495  -7.34738  1.000 22.25431 ? 198  PHE A CA  1 
ATOM   1401 C C   . PHE A 1 179 ? -21.43968 17.49701  -6.81914  1.000 26.88808 ? 198  PHE A C   1 
ATOM   1402 O O   . PHE A 1 179 ? -20.74685 17.43831  -5.80035  1.000 24.85732 ? 198  PHE A O   1 
ATOM   1403 C CB  . PHE A 1 179 ? -23.21925 15.77786  -6.38514  1.000 24.94950 ? 198  PHE A CB  1 
ATOM   1404 C CG  . PHE A 1 179 ? -23.97526 14.58440  -6.88053  1.000 25.25887 ? 198  PHE A CG  1 
ATOM   1405 C CD1 . PHE A 1 179 ? -24.91202 14.70646  -7.90639  1.000 24.80911 ? 198  PHE A CD1 1 
ATOM   1406 C CD2 . PHE A 1 179 ? -23.66892 13.31311  -6.40026  1.000 19.47063 ? 198  PHE A CD2 1 
ATOM   1407 C CE1 . PHE A 1 179 ? -25.59856 13.58681  -8.38178  1.000 27.80175 ? 198  PHE A CE1 1 
ATOM   1408 C CE2 . PHE A 1 179 ? -24.33861 12.19160  -6.88066  1.000 22.15842 ? 198  PHE A CE2 1 
ATOM   1409 C CZ  . PHE A 1 179 ? -25.30131 12.32552  -7.86941  1.000 23.79942 ? 198  PHE A CZ  1 
ATOM   1410 N N   . TYR A 1 180 ? -21.61935 18.62390  -7.51851  1.000 25.52978 ? 199  TYR A N   1 
ATOM   1411 C CA  . TYR A 1 180 ? -21.10277 19.88923  -7.00488  1.000 26.41205 ? 199  TYR A CA  1 
ATOM   1412 C C   . TYR A 1 180 ? -21.68579 20.18841  -5.63085  1.000 27.00911 ? 199  TYR A C   1 
ATOM   1413 O O   . TYR A 1 180 ? -20.98916 20.69180  -4.73923  1.000 26.44724 ? 199  TYR A O   1 
ATOM   1414 C CB  . TYR A 1 180 ? -21.40628 21.02052  -7.99396  1.000 22.14852 ? 199  TYR A CB  1 
ATOM   1415 C CG  . TYR A 1 180 ? -20.62463 20.87453  -9.28360  1.000 27.96363 ? 199  TYR A CG  1 
ATOM   1416 C CD1 . TYR A 1 180 ? -19.32697 21.36849  -9.39037  1.000 24.65024 ? 199  TYR A CD1 1 
ATOM   1417 C CD2 . TYR A 1 180 ? -21.17709 20.23076  -10.38939 1.000 27.43067 ? 199  TYR A CD2 1 
ATOM   1418 C CE1 . TYR A 1 180 ? -18.59713 21.21721  -10.56255 1.000 24.55670 ? 199  TYR A CE1 1 
ATOM   1419 C CE2 . TYR A 1 180 ? -20.45451 20.07322  -11.56561 1.000 27.07849 ? 199  TYR A CE2 1 
ATOM   1420 C CZ  . TYR A 1 180 ? -19.16604 20.57454  -11.64778 1.000 25.87637 ? 199  TYR A CZ  1 
ATOM   1421 O OH  . TYR A 1 180 ? -18.44621 20.43007  -12.81857 1.000 28.55782 ? 199  TYR A OH  1 
ATOM   1422 N N   . SER A 1 181 ? -22.95091 19.82821  -5.42461  1.000 26.64194 ? 200  SER A N   1 
ATOM   1423 C CA  . SER A 1 181 ? -23.61387 20.03923  -4.14357  1.000 32.54430 ? 200  SER A CA  1 
ATOM   1424 C C   . SER A 1 181 ? -23.01737 19.21391  -3.00360  1.000 36.12850 ? 200  SER A C   1 
ATOM   1425 O O   . SER A 1 181 ? -23.34946 19.47845  -1.83918  1.000 34.78867 ? 200  SER A O   1 
ATOM   1426 C CB  . SER A 1 181 ? -25.10400 19.73632  -4.29929  1.000 26.94089 ? 200  SER A CB  1 
ATOM   1427 O OG  . SER A 1 181 ? -25.28629 18.39306  -4.71061  1.000 32.08505 ? 200  SER A OG  1 
ATOM   1428 N N   . ASP A 1 182 ? -22.16166 18.22702  -3.29914  1.000 33.37156 ? 201  ASP A N   1 
ATOM   1429 C CA  . ASP A 1 182 ? -21.41788 17.50829  -2.26214  1.000 34.28039 ? 201  ASP A CA  1 
ATOM   1430 C C   . ASP A 1 182 ? -20.21496 18.28473  -1.72074  1.000 40.68630 ? 201  ASP A C   1 
ATOM   1431 O O   . ASP A 1 182 ? -19.60800 17.83545  -0.74054  1.000 39.43367 ? 201  ASP A O   1 
ATOM   1432 C CB  . ASP A 1 182 ? -20.87588 16.16391  -2.78074  1.000 27.24104 ? 201  ASP A CB  1 
ATOM   1433 C CG  . ASP A 1 182 ? -21.93160 15.06555  -2.88984  1.000 35.12470 ? 201  ASP A CG  1 
ATOM   1434 O OD1 . ASP A 1 182 ? -23.10744 15.28359  -2.53991  1.000 30.87325 ? 201  ASP A OD1 1 
ATOM   1435 O OD2 . ASP A 1 182 ? -21.54051 13.94095  -3.28648  1.000 28.02883 ? 201  ASP A OD2 1 
ATOM   1436 N N   . GLN A 1 183 ? -19.84077 19.41790  -2.32642  1.000 41.74038 ? 202  GLN A N   1 
ATOM   1437 C CA  . GLN A 1 183 ? -18.49235 19.96620  -2.16884  1.000 48.07277 ? 202  GLN A CA  1 
ATOM   1438 C C   . GLN A 1 183 ? -18.36729 21.14974  -1.20592  1.000 49.70924 ? 202  GLN A C   1 
ATOM   1439 O O   . GLN A 1 183 ? -17.28161 21.73622  -1.13455  1.000 55.20270 ? 202  GLN A O   1 
ATOM   1440 C CB  . GLN A 1 183 ? -17.92441 20.39232  -3.53897  1.000 40.95946 ? 202  GLN A CB  1 
ATOM   1441 C CG  . GLN A 1 183 ? -18.12809 19.40708  -4.69144  1.000 35.39049 ? 202  GLN A CG  1 
ATOM   1442 C CD  . GLN A 1 183 ? -17.48527 18.05289  -4.42091  1.000 40.98379 ? 202  GLN A CD  1 
ATOM   1443 O OE1 . GLN A 1 183 ? -16.31323 17.97494  -4.03894  1.000 44.86799 ? 202  GLN A OE1 1 
ATOM   1444 N NE2 . GLN A 1 183 ? -18.24373 16.98374  -4.62211  1.000 35.13370 ? 202  GLN A NE2 1 
ATOM   1445 N N   . ASN A 1 184 ? -19.41323 21.52052  -0.46686  1.000 50.38321 ? 203  ASN A N   1 
ATOM   1446 C CA  . ASN A 1 184 ? -19.32176 22.70657  0.38836   1.000 57.44612 ? 203  ASN A CA  1 
ATOM   1447 C C   . ASN A 1 184 ? -18.26244 22.52562  1.48058   1.000 64.00959 ? 203  ASN A C   1 
ATOM   1448 O O   . ASN A 1 184 ? -18.33217 21.58561  2.28129   1.000 65.57480 ? 203  ASN A O   1 
ATOM   1449 C CB  . ASN A 1 184 ? -20.68873 23.02637  0.99425   1.000 56.41986 ? 203  ASN A CB  1 
ATOM   1450 C CG  . ASN A 1 184 ? -21.80624 23.00212  -0.04421  1.000 53.97293 ? 203  ASN A CG  1 
ATOM   1451 O OD1 . ASN A 1 184 ? -21.60469 23.38389  -1.20203  1.000 49.58172 ? 203  ASN A OD1 1 
ATOM   1452 N ND2 . ASN A 1 184 ? -22.98981 22.54960  0.36626   1.000 51.90566 ? 203  ASN A ND2 1 
ATOM   1453 N N   . VAL A 1 185 ? -17.28879 23.44649  1.51285   1.000 61.66796 ? 204  VAL A N   1 
ATOM   1454 C CA  . VAL A 1 185 ? -16.05786 23.30688  2.29344   1.000 63.95825 ? 204  VAL A CA  1 
ATOM   1455 C C   . VAL A 1 185 ? -16.20870 23.95696  3.66726   1.000 71.62464 ? 204  VAL A C   1 
ATOM   1456 O O   . VAL A 1 185 ? -17.19052 24.66277  3.93004   1.000 68.55643 ? 204  VAL A O   1 
ATOM   1457 C CB  . VAL A 1 185 ? -14.85482 23.90395  1.52772   1.000 62.82822 ? 204  VAL A CB  1 
ATOM   1458 C CG1 . VAL A 1 185 ? -14.76620 25.41458  1.72650   1.000 61.18234 ? 204  VAL A CG1 1 
ATOM   1459 C CG2 . VAL A 1 185 ? -13.54636 23.21779  1.92096   1.000 55.07633 ? 204  VAL A CG2 1 
ATOM   1460 N N   . ASP A 1 186 ? -15.22882 23.72870  4.54553   1.000 72.56952 ? 205  ASP A N   1 
ATOM   1461 C CA  . ASP A 1 186 ? -15.27760 24.14098  5.94423   1.000 68.86544 ? 205  ASP A CA  1 
ATOM   1462 C C   . ASP A 1 186 ? -13.90934 23.90869  6.57570   1.000 64.44925 ? 205  ASP A C   1 
ATOM   1463 O O   . ASP A 1 186 ? -13.19537 22.97622  6.19981   1.000 63.39442 ? 205  ASP A O   1 
ATOM   1464 C CB  . ASP A 1 186 ? -16.35393 23.35889  6.71014   1.000 67.14376 ? 205  ASP A CB  1 
ATOM   1465 C CG  . ASP A 1 186 ? -16.80533 24.06545  7.97251   1.000 73.96636 ? 205  ASP A CG  1 
ATOM   1466 O OD1 . ASP A 1 186 ? -16.36724 25.21458  8.19980   1.000 77.06515 ? 205  ASP A OD1 1 
ATOM   1467 O OD2 . ASP A 1 186 ? -17.59859 23.47120  8.73720   1.000 68.05206 ? 205  ASP A OD2 1 
ATOM   1468 N N   . SER A 1 187 ? -13.54692 24.77017  7.53151   1.000 64.86512 ? 206  SER A N   1 
ATOM   1469 C CA  . SER A 1 187 ? -12.33291 24.58155  8.32047   1.000 58.96775 ? 206  SER A CA  1 
ATOM   1470 C C   . SER A 1 187 ? -12.61326 24.10619  9.73742   1.000 61.02645 ? 206  SER A C   1 
ATOM   1471 O O   . SER A 1 187 ? -11.68183 23.66343  10.42174  1.000 51.77809 ? 206  SER A O   1 
ATOM   1472 C CB  . SER A 1 187 ? -11.50554 25.87880  8.38700   1.000 52.23688 ? 206  SER A CB  1 
ATOM   1473 O OG  . SER A 1 187 ? -12.14806 26.95773  7.72891   1.000 58.21467 ? 206  SER A OG  1 
ATOM   1474 N N   . ARG A 1 188 ? -13.86360 24.19324  10.19642  1.000 60.88315 ? 207  ARG A N   1 
ATOM   1475 C CA  . ARG A 1 188 ? -14.21368 23.70867  11.52151  1.000 59.58937 ? 207  ARG A CA  1 
ATOM   1476 C C   . ARG A 1 188 ? -14.31429 22.19084  11.57391  1.000 54.08645 ? 207  ARG A C   1 
ATOM   1477 O O   . ARG A 1 188 ? -14.22581 21.61454  12.66302  1.000 53.64859 ? 207  ARG A O   1 
ATOM   1478 C CB  . ARG A 1 188 ? -15.53185 24.33811  11.98028  1.000 60.72762 ? 207  ARG A CB  1 
ATOM   1479 N N   . ASP A 1 189 ? -14.48392 21.52717  10.42947  1.000 47.25771 ? 208  ASP A N   1 
ATOM   1480 C CA  . ASP A 1 189 ? -14.56502 20.07225  10.39728  1.000 39.25384 ? 208  ASP A CA  1 
ATOM   1481 C C   . ASP A 1 189 ? -13.32329 19.50229  9.72615   1.000 36.04371 ? 208  ASP A C   1 
ATOM   1482 O O   . ASP A 1 189 ? -13.33388 19.23012  8.51511   1.000 28.85817 ? 208  ASP A O   1 
ATOM   1483 C CB  . ASP A 1 189 ? -15.83171 19.61122  9.67850   1.000 40.71734 ? 208  ASP A CB  1 
ATOM   1484 C CG  . ASP A 1 189 ? -16.10368 18.14024  9.88345   1.000 37.53625 ? 208  ASP A CG  1 
ATOM   1485 O OD1 . ASP A 1 189 ? -15.17931 17.40515  10.30920  1.000 34.96138 ? 208  ASP A OD1 1 
ATOM   1486 O OD2 . ASP A 1 189 ? -17.25324 17.71517  9.63349   1.000 44.34964 ? 208  ASP A OD2 1 
ATOM   1487 N N   . PRO A 1 190 ? -12.24619 19.25730  10.47650  1.000 36.14459 ? 209  PRO A N   1 
ATOM   1488 C CA  . PRO A 1 190 ? -10.99908 18.81214  9.83552   1.000 33.42689 ? 209  PRO A CA  1 
ATOM   1489 C C   . PRO A 1 190 ? -11.10549 17.44187  9.19683   1.000 30.56358 ? 209  PRO A C   1 
ATOM   1490 O O   . PRO A 1 190 ? -10.43436 17.19570  8.18657   1.000 30.92184 ? 209  PRO A O   1 
ATOM   1491 C CB  . PRO A 1 190 ? -9.97476  18.82699  10.98362  1.000 39.77951 ? 209  PRO A CB  1 
ATOM   1492 C CG  . PRO A 1 190 ? -10.74586 19.16843  12.24851  1.000 41.82544 ? 209  PRO A CG  1 
ATOM   1493 C CD  . PRO A 1 190 ? -12.20212 19.14008  11.94371  1.000 42.85977 ? 209  PRO A CD  1 
ATOM   1494 N N   . VAL A 1 191 ? -11.92976 16.54472  9.74271   1.000 24.60781 ? 210  VAL A N   1 
ATOM   1495 C CA  . VAL A 1 191 ? -12.13914 15.24791  9.10063   1.000 29.11603 ? 210  VAL A CA  1 
ATOM   1496 C C   . VAL A 1 191 ? -12.70484 15.43070  7.69627   1.000 25.53548 ? 210  VAL A C   1 
ATOM   1497 O O   . VAL A 1 191 ? -12.19322 14.86737  6.72172   1.000 26.72518 ? 210  VAL A O   1 
ATOM   1498 C CB  . VAL A 1 191 ? -13.05816 14.36611  9.96328   1.000 31.47505 ? 210  VAL A CB  1 
ATOM   1499 C CG1 . VAL A 1 191 ? -13.11681 12.96703  9.39488   1.000 29.78112 ? 210  VAL A CG1 1 
ATOM   1500 C CG2 . VAL A 1 191 ? -12.56163 14.35631  11.40931  1.000 35.22473 ? 210  VAL A CG2 1 
ATOM   1501 N N   . GLN A 1 192 ? -13.77516 16.21382  7.57076   1.000 28.03136 ? 211  GLN A N   1 
ATOM   1502 C CA  . GLN A 1 192 ? -14.35243 16.43464  6.25058   1.000 26.50173 ? 211  GLN A CA  1 
ATOM   1503 C C   . GLN A 1 192 ? -13.39571 17.20962  5.35425   1.000 27.09230 ? 211  GLN A C   1 
ATOM   1504 O O   . GLN A 1 192 ? -13.27928 16.90448  4.16057   1.000 24.69985 ? 211  GLN A O   1 
ATOM   1505 C CB  . GLN A 1 192 ? -15.69708 17.15502  6.36261   1.000 26.75273 ? 211  GLN A CB  1 
ATOM   1506 C CG  . GLN A 1 192 ? -16.42902 17.26282  5.02121   1.000 33.38427 ? 211  GLN A CG  1 
ATOM   1507 C CD  . GLN A 1 192 ? -17.00951 15.92900  4.53483   1.000 35.74254 ? 211  GLN A CD  1 
ATOM   1508 O OE1 . GLN A 1 192 ? -17.01540 14.92941  5.26169   1.000 31.50196 ? 211  GLN A OE1 1 
ATOM   1509 N NE2 . GLN A 1 192 ? -17.47841 15.90836  3.28680   1.000 37.00022 ? 211  GLN A NE2 1 
ATOM   1510 N N   . LEU A 1 193 ? -12.69772 18.21097  5.90886   1.000 22.53464 ? 212  LEU A N   1 
ATOM   1511 C CA  . LEU A 1 193 ? -11.74946 18.97350  5.09929   1.000 25.73198 ? 212  LEU A CA  1 
ATOM   1512 C C   . LEU A 1 193 ? -10.67849 18.05922  4.52267   1.000 19.43019 ? 212  LEU A C   1 
ATOM   1513 O O   . LEU A 1 193 ? -10.33895 18.15422  3.33622   1.000 25.23061 ? 212  LEU A O   1 
ATOM   1514 C CB  . LEU A 1 193 ? -11.10821 20.09209  5.92499   1.000 26.71000 ? 212  LEU A CB  1 
ATOM   1515 C CG  . LEU A 1 193 ? -9.97343  20.86112  5.21858   1.000 24.78502 ? 212  LEU A CG  1 
ATOM   1516 C CD1 . LEU A 1 193 ? -10.45940 21.51571  3.91636   1.000 28.41923 ? 212  LEU A CD1 1 
ATOM   1517 C CD2 . LEU A 1 193 ? -9.33567  21.90288  6.12836   1.000 29.05336 ? 212  LEU A CD2 1 
ATOM   1518 N N   . ASN A 1 194 ? -10.15192 17.14879  5.33783   1.000 23.49152 ? 213  ASN A N   1 
ATOM   1519 C CA  . ASN A 1 194 ? -9.16184  16.21377  4.81980   1.000 23.42425 ? 213  ASN A CA  1 
ATOM   1520 C C   . ASN A 1 194 ? -9.74032  15.34897  3.70955   1.000 27.01740 ? 213  ASN A C   1 
ATOM   1521 O O   . ASN A 1 194 ? -9.04515  15.03735  2.73257   1.000 21.42422 ? 213  ASN A O   1 
ATOM   1522 C CB  . ASN A 1 194 ? -8.61818  15.32989  5.93247   1.000 24.13299 ? 213  ASN A CB  1 
ATOM   1523 C CG  . ASN A 1 194 ? -7.46606  14.48947  5.46355   1.000 29.32817 ? 213  ASN A CG  1 
ATOM   1524 O OD1 . ASN A 1 194 ? -6.42764  15.01798  5.06048   1.000 32.49955 ? 213  ASN A OD1 1 
ATOM   1525 N ND2 . ASN A 1 194 ? -7.64454  13.17499  5.47219   1.000 34.85640 ? 213  ASN A ND2 1 
ATOM   1526 N N   . LEU A 1 195 ? -11.00913 14.94324  3.83651   1.000 23.65348 ? 214  LEU A N   1 
ATOM   1527 C CA  . LEU A 1 195 ? -11.60353 14.10941  2.79587   1.000 22.74910 ? 214  LEU A CA  1 
ATOM   1528 C C   . LEU A 1 195 ? -11.68920 14.86812  1.48278   1.000 24.32754 ? 214  LEU A C   1 
ATOM   1529 O O   . LEU A 1 195 ? -11.35244 14.33063  0.41810   1.000 22.40807 ? 214  LEU A O   1 
ATOM   1530 C CB  . LEU A 1 195 ? -12.98948 13.61802  3.22455   1.000 26.51345 ? 214  LEU A CB  1 
ATOM   1531 C CG  . LEU A 1 195 ? -12.94410 12.53995  4.30804   1.000 26.31012 ? 214  LEU A CG  1 
ATOM   1532 C CD1 . LEU A 1 195 ? -14.34384 12.20652  4.75601   1.000 27.52998 ? 214  LEU A CD1 1 
ATOM   1533 C CD2 . LEU A 1 195 ? -12.19818 11.29247  3.83718   1.000 28.67505 ? 214  LEU A CD2 1 
ATOM   1534 N N   . LEU A 1 196 ? -12.13868 16.12737  1.54200   1.000 20.66236 ? 215  LEU A N   1 
ATOM   1535 C CA  . LEU A 1 196 ? -12.22355 16.94837  0.34222   1.000 22.47420 ? 215  LEU A CA  1 
ATOM   1536 C C   . LEU A 1 196 ? -10.84727 17.17783  -0.26785  1.000 23.44747 ? 215  LEU A C   1 
ATOM   1537 O O   . LEU A 1 196 ? -10.69118 17.16779  -1.49913  1.000 19.31411 ? 215  LEU A O   1 
ATOM   1538 C CB  . LEU A 1 196 ? -12.87361 18.28381  0.67503   1.000 23.92791 ? 215  LEU A CB  1 
ATOM   1539 C CG  . LEU A 1 196 ? -14.28715 18.14712  1.22464   1.000 29.83964 ? 215  LEU A CG  1 
ATOM   1540 C CD1 . LEU A 1 196 ? -14.75522 19.46910  1.82910   1.000 34.89863 ? 215  LEU A CD1 1 
ATOM   1541 C CD2 . LEU A 1 196 ? -15.20416 17.69785  0.08853   1.000 31.13185 ? 215  LEU A CD2 1 
ATOM   1542 N N   . TYR A 1 197 ? -9.84432  17.41346  0.58219   1.000 18.38481 ? 216  TYR A N   1 
ATOM   1543 C CA  . TYR A 1 197 ? -8.48977  17.64795  0.09262   1.000 19.27259 ? 216  TYR A CA  1 
ATOM   1544 C C   . TYR A 1 197 ? -7.93777  16.41652  -0.60582  1.000 18.14376 ? 216  TYR A C   1 
ATOM   1545 O O   . TYR A 1 197 ? -7.38671  16.51342  -1.70861  1.000 18.26631 ? 216  TYR A O   1 
ATOM   1546 C CB  . TYR A 1 197 ? -7.57691  18.03092  1.24405   1.000 16.57018 ? 216  TYR A CB  1 
ATOM   1547 C CG  . TYR A 1 197 ? -6.11541  17.93159  0.88400   1.000 15.21879 ? 216  TYR A CG  1 
ATOM   1548 C CD1 . TYR A 1 197 ? -5.56266  18.77328  -0.07389  1.000 19.21094 ? 216  TYR A CD1 1 
ATOM   1549 C CD2 . TYR A 1 197 ? -5.29384  16.98897  1.49428   1.000 18.86775 ? 216  TYR A CD2 1 
ATOM   1550 C CE1 . TYR A 1 197 ? -4.21191  18.69118  -0.40717  1.000 15.90663 ? 216  TYR A CE1 1 
ATOM   1551 C CE2 . TYR A 1 197 ? -3.94103  16.90378  1.18315   1.000 18.92565 ? 216  TYR A CE2 1 
ATOM   1552 C CZ  . TYR A 1 197 ? -3.41507  17.74929  0.22808   1.000 18.23022 ? 216  TYR A CZ  1 
ATOM   1553 O OH  . TYR A 1 197 ? -2.08780  17.68623  -0.10387  1.000 17.84206 ? 216  TYR A OH  1 
ATOM   1554 N N   . VAL A 1 198 ? -8.04741  15.24958  0.04108   1.000 16.49826 ? 217  VAL A N   1 
ATOM   1555 C CA  . VAL A 1 198 ? -7.52427  14.02782  -0.56532  1.000 18.34459 ? 217  VAL A CA  1 
ATOM   1556 C C   . VAL A 1 198 ? -8.18016  13.77443  -1.92053  1.000 19.47153 ? 217  VAL A C   1 
ATOM   1557 O O   . VAL A 1 198 ? -7.50601  13.41102  -2.89187  1.000 16.27276 ? 217  VAL A O   1 
ATOM   1558 C CB  . VAL A 1 198 ? -7.69554  12.84140  0.39947   1.000 22.37110 ? 217  VAL A CB  1 
ATOM   1559 C CG1 . VAL A 1 198 ? -7.54085  11.49406  -0.33843  1.000 22.31980 ? 217  VAL A CG1 1 
ATOM   1560 C CG2 . VAL A 1 198 ? -6.66948  12.97043  1.52359   1.000 24.09421 ? 217  VAL A CG2 1 
ATOM   1561 N N   . GLN A 1 199 ? -9.49223  14.00633  -2.02949  1.000 21.45831 ? 218  GLN A N   1 
ATOM   1562 C CA  . GLN A 1 199 ? -10.14196 13.70655  -3.30130  1.000 18.59876 ? 218  GLN A CA  1 
ATOM   1563 C C   . GLN A 1 199 ? -9.71481  14.70276  -4.38100  1.000 17.30805 ? 218  GLN A C   1 
ATOM   1564 O O   . GLN A 1 199 ? -9.40772  14.30097  -5.51256  1.000 18.65413 ? 218  GLN A O   1 
ATOM   1565 C CB  . GLN A 1 199 ? -11.66715 13.64870  -3.10990  1.000 22.93309 ? 218  GLN A CB  1 
ATOM   1566 C CG  . GLN A 1 199 ? -12.52181 13.76428  -4.37374  1.000 25.06142 ? 218  GLN A CG  1 
ATOM   1567 C CD  . GLN A 1 199 ? -13.94707 14.26325  -4.09982  1.000 42.42332 ? 218  GLN A CD  1 
ATOM   1568 O OE1 . GLN A 1 199 ? -14.67030 14.67655  -5.02054  1.000 40.55403 ? 218  GLN A OE1 1 
ATOM   1569 N NE2 . GLN A 1 199 ? -14.37208 14.17937  -2.82895  1.000 42.29833 ? 218  GLN A NE2 1 
ATOM   1570 N N   . ALA A 1 200 ? -9.60585  15.99289  -4.03916  1.000 15.17546 ? 219  ALA A N   1 
ATOM   1571 C CA  . ALA A 1 200 ? -9.17473  16.97050  -5.04361  1.000 19.70027 ? 219  ALA A CA  1 
ATOM   1572 C C   . ALA A 1 200 ? -7.72944  16.73093  -5.46019  1.000 15.57714 ? 219  ALA A C   1 
ATOM   1573 O O   . ALA A 1 200 ? -7.39092  16.83605  -6.64823  1.000 14.75324 ? 219  ALA A O   1 
ATOM   1574 C CB  . ALA A 1 200 ? -9.34036  18.39845  -4.52182  1.000 17.66356 ? 219  ALA A CB  1 
ATOM   1575 N N   . ARG A 1 201 ? -6.87060  16.41240  -4.48837  1.000 17.60951 ? 220  ARG A N   1 
ATOM   1576 C CA  . ARG A 1 201 ? -5.46611  16.11803  -4.76355  1.000 15.57593 ? 220  ARG A CA  1 
ATOM   1577 C C   . ARG A 1 201 ? -5.31844  14.88624  -5.64461  1.000 15.12732 ? 220  ARG A C   1 
ATOM   1578 O O   . ARG A 1 201 ? -4.57856  14.89536  -6.63654  1.000 15.38740 ? 220  ARG A O   1 
ATOM   1579 C CB  . ARG A 1 201 ? -4.72981  15.90564  -3.43899  1.000 14.76643 ? 220  ARG A CB  1 
ATOM   1580 C CG  . ARG A 1 201 ? -3.21406  15.80385  -3.54997  1.000 20.63676 ? 220  ARG A CG  1 
ATOM   1581 C CD  . ARG A 1 201 ? -2.60194  14.87401  -2.47352  1.000 17.44628 ? 220  ARG A CD  1 
ATOM   1582 N NE  . ARG A 1 201 ? -3.33462  13.62794  -2.23561  1.000 17.15332 ? 220  ARG A NE  1 
ATOM   1583 C CZ  . ARG A 1 201 ? -3.23675  12.90305  -1.12490  1.000 23.05796 ? 220  ARG A CZ  1 
ATOM   1584 N NH1 . ARG A 1 201 ? -2.54965  13.33477  -0.07513  1.000 19.57655 ? 220  ARG A NH1 1 
ATOM   1585 N NH2 . ARG A 1 201 ? -3.84352  11.71604  -1.06327  1.000 24.15138 ? 220  ARG A NH2 1 
ATOM   1586 N N   . ASP A 1 202 ? -6.00226  13.80362  -5.29044  1.000 15.53876 ? 221  ASP A N   1 
ATOM   1587 C CA  . ASP A 1 202 ? -5.82511  12.58347  -6.06503  1.000 16.61840 ? 221  ASP A CA  1 
ATOM   1588 C C   . ASP A 1 202 ? -6.29436  12.77701  -7.49760  1.000 16.12164 ? 221  ASP A C   1 
ATOM   1589 O O   . ASP A 1 202 ? -5.65891  12.27714  -8.43189  1.000 16.46185 ? 221  ASP A O   1 
ATOM   1590 C CB  . ASP A 1 202 ? -6.55197  11.41739  -5.40813  1.000 19.57366 ? 221  ASP A CB  1 
ATOM   1591 C CG  . ASP A 1 202 ? -5.87782  10.95402  -4.13298  1.000 22.19169 ? 221  ASP A CG  1 
ATOM   1592 O OD1 . ASP A 1 202 ? -4.76300  11.43065  -3.82181  1.000 18.84807 ? 221  ASP A OD1 1 
ATOM   1593 O OD2 . ASP A 1 202 ? -6.47788  10.10623  -3.44518  1.000 20.82208 ? 221  ASP A OD2 1 
ATOM   1594 N N   . ASP A 1 203 ? -7.39133  13.51851  -7.68860  1.000 14.22419 ? 222  ASP A N   1 
ATOM   1595 C CA  . ASP A 1 203 ? -7.88464  13.75597  -9.04127  1.000 16.18495 ? 222  ASP A CA  1 
ATOM   1596 C C   . ASP A 1 203 ? -6.87336  14.53311  -9.86999  1.000 18.83847 ? 222  ASP A C   1 
ATOM   1597 O O   . ASP A 1 203 ? -6.72664  14.27674  -11.07177 1.000 17.06832 ? 222  ASP A O   1 
ATOM   1598 C CB  . ASP A 1 203 ? -9.22153  14.50502  -9.01259  1.000 17.81853 ? 222  ASP A CB  1 
ATOM   1599 C CG  . ASP A 1 203 ? -10.38943 13.62332  -8.60171  1.000 23.36575 ? 222  ASP A CG  1 
ATOM   1600 O OD1 . ASP A 1 203 ? -10.23292 12.38893  -8.64455  1.000 27.19319 ? 222  ASP A OD1 1 
ATOM   1601 O OD2 . ASP A 1 203 ? -11.46111 14.17536  -8.23852  1.000 20.95771 ? 222  ASP A OD2 1 
ATOM   1602 N N   . ILE A 1 204 ? -6.18320  15.50940  -9.25842  1.000 12.55628 ? 223  ILE A N   1 
ATOM   1603 C CA  . ILE A 1 204 ? -5.17236  16.25400  -9.99501  1.000 14.98632 ? 223  ILE A CA  1 
ATOM   1604 C C   . ILE A 1 204 ? -3.95521  15.37627  -10.27425 1.000 13.83674 ? 223  ILE A C   1 
ATOM   1605 O O   . ILE A 1 204 ? -3.48408  15.29968  -11.41425 1.000 16.03946 ? 223  ILE A O   1 
ATOM   1606 C CB  . ILE A 1 204 ? -4.80120  17.55483  -9.25521  1.000 13.76396 ? 223  ILE A CB  1 
ATOM   1607 C CG1 . ILE A 1 204 ? -5.89831  18.61775  -9.45604  1.000 11.86324 ? 223  ILE A CG1 1 
ATOM   1608 C CG2 . ILE A 1 204 ? -3.50116  18.11420  -9.74827  1.000 18.26693 ? 223  ILE A CG2 1 
ATOM   1609 C CD1 . ILE A 1 204 ? -6.08820  19.54134  -8.25307  1.000 14.13451 ? 223  ILE A CD1 1 
ATOM   1610 N N   . LEU A 1 205 ? -3.44909  14.67247  -9.25385  1.000 13.95026 ? 224  LEU A N   1 
ATOM   1611 C CA  . LEU A 1 205 ? -2.24226  13.86139  -9.43431  1.000 14.68803 ? 224  LEU A CA  1 
ATOM   1612 C C   . LEU A 1 205 ? -2.46749  12.73617  -10.44475 1.000 19.11042 ? 224  LEU A C   1 
ATOM   1613 O O   . LEU A 1 205 ? -1.59218  12.43771  -11.26719 1.000 19.21629 ? 224  LEU A O   1 
ATOM   1614 C CB  . LEU A 1 205 ? -1.79971  13.29260  -8.08704  1.000 15.69203 ? 224  LEU A CB  1 
ATOM   1615 C CG  . LEU A 1 205 ? -1.24847  14.29112  -7.05473  1.000 13.55384 ? 224  LEU A CG  1 
ATOM   1616 C CD1 . LEU A 1 205 ? -0.76618  13.52914  -5.83157  1.000 19.61980 ? 224  LEU A CD1 1 
ATOM   1617 C CD2 . LEU A 1 205 ? -0.10472  15.09904  -7.63641  1.000 14.90443 ? 224  LEU A CD2 1 
ATOM   1618 N N   . ASN A 1 206 ? -3.63426  12.10858  -10.40959 1.000 16.30819 ? 225  ASN A N   1 
ATOM   1619 C CA  . ASN A 1 206 ? -3.93403  11.03372  -11.34872 1.000 19.01312 ? 225  ASN A CA  1 
ATOM   1620 C C   . ASN A 1 206 ? -4.49576  11.50150  -12.69350 1.000 25.19854 ? 225  ASN A C   1 
ATOM   1621 O O   . ASN A 1 206 ? -4.75015  10.66444  -13.56608 1.000 20.91866 ? 225  ASN A O   1 
ATOM   1622 C CB  . ASN A 1 206 ? -4.80152  9.97852   -10.63439 1.000 21.27090 ? 225  ASN A CB  1 
ATOM   1623 C CG  . ASN A 1 206 ? -6.29562  10.28902  -10.61539 1.000 27.81109 ? 225  ASN A CG  1 
ATOM   1624 O OD1 . ASN A 1 206 ? -6.84202  11.02557  -11.43799 1.000 28.67415 ? 225  ASN A OD1 1 
ATOM   1625 N ND2 . ASN A 1 206 ? -6.97583  9.67726   -9.64937  1.000 27.38955 ? 225  ASN A ND2 1 
ATOM   1626 N N   . GLY A 1 207 ? -4.61447  12.80578  -12.92490 1.000 19.88748 ? 226  GLY A N   1 
ATOM   1627 C CA  . GLY A 1 207 ? -4.98634  13.28919  -14.23944 1.000 22.13140 ? 226  GLY A CA  1 
ATOM   1628 C C   . GLY A 1 207 ? -6.47120  13.32755  -14.52631 1.000 19.69574 ? 226  GLY A C   1 
ATOM   1629 O O   . GLY A 1 207 ? -6.86049  13.79193  -15.60961 1.000 21.54880 ? 226  GLY A O   1 
ATOM   1630 N N   . SER A 1 208 ? -7.31080  12.85768  -13.60218 1.000 18.05813 ? 227  SER A N   1 
ATOM   1631 C CA  . SER A 1 208 ? -8.75895  12.97311  -13.77177 1.000 18.35303 ? 227  SER A CA  1 
ATOM   1632 C C   . SER A 1 208 ? -9.18799  14.41998  -13.87770 1.000 22.82046 ? 227  SER A C   1 
ATOM   1633 O O   . SER A 1 208 ? -10.15399 14.73985  -14.58433 1.000 19.97810 ? 227  SER A O   1 
ATOM   1634 C CB  . SER A 1 208 ? -9.49173  12.32822  -12.59014 1.000 18.64250 ? 227  SER A CB  1 
ATOM   1635 O OG  . SER A 1 208 ? -9.17346  10.95558  -12.50042 1.000 31.45204 ? 227  SER A OG  1 
ATOM   1636 N N   . HIS A 1 209 ? -8.50551  15.30126  -13.15222 1.000 18.33031 ? 228  HIS A N   1 
ATOM   1637 C CA  . HIS A 1 209 ? -8.75280  16.73384  -13.23456 1.000 14.26891 ? 228  HIS A CA  1 
ATOM   1638 C C   . HIS A 1 209 ? -7.56876  17.36964  -13.95408 1.000 15.29706 ? 228  HIS A C   1 
ATOM   1639 O O   . HIS A 1 209 ? -6.52286  17.63089  -13.33352 1.000 15.64405 ? 228  HIS A O   1 
ATOM   1640 C CB  . HIS A 1 209 ? -8.95002  17.33893  -11.83639 1.000 13.13741 ? 228  HIS A CB  1 
ATOM   1641 C CG  . HIS A 1 209 ? -9.29460  18.79526  -11.86725 1.000 15.26435 ? 228  HIS A CG  1 
ATOM   1642 N ND1 . HIS A 1 209 ? -9.39582  19.56964  -10.73092 1.000 18.05453 ? 228  HIS A ND1 1 
ATOM   1643 C CD2 . HIS A 1 209 ? -9.54056  19.62101  -12.90989 1.000 14.49198 ? 228  HIS A CD2 1 
ATOM   1644 C CE1 . HIS A 1 209 ? -9.70514  20.80969  -11.07318 1.000 18.22340 ? 228  HIS A CE1 1 
ATOM   1645 N NE2 . HIS A 1 209 ? -9.78948  20.86882  -12.39097 1.000 17.45776 ? 228  HIS A NE2 1 
ATOM   1646 N N   . PRO A 1 210 ? -7.67210  17.61259  -15.25703 1.000 14.99334 ? 229  PRO A N   1 
ATOM   1647 C CA  . PRO A 1 210 ? -6.52603  18.12344  -16.01510 1.000 15.61581 ? 229  PRO A CA  1 
ATOM   1648 C C   . PRO A 1 210 ? -6.29028  19.58965  -15.67965 1.000 19.44467 ? 229  PRO A C   1 
ATOM   1649 O O   . PRO A 1 210 ? -7.22659  20.39526  -15.64932 1.000 15.84028 ? 229  PRO A O   1 
ATOM   1650 C CB  . PRO A 1 210 ? -6.95741  17.94034  -17.48106 1.000 17.29892 ? 229  PRO A CB  1 
ATOM   1651 C CG  . PRO A 1 210 ? -8.16464  17.01938  -17.43598 1.000 18.77101 ? 229  PRO A CG  1 
ATOM   1652 C CD  . PRO A 1 210 ? -8.83354  17.35741  -16.12257 1.000 17.53505 ? 229  PRO A CD  1 
ATOM   1653 N N   . VAL A 1 211 ? -5.03230  19.93287  -15.41167 1.000 15.01087 ? 230  VAL A N   1 
ATOM   1654 C CA  . VAL A 1 211 ? -4.68641  21.29879  -15.05122 1.000 15.15395 ? 230  VAL A CA  1 
ATOM   1655 C C   . VAL A 1 211 ? -3.45788  21.71517  -15.84498 1.000 15.16848 ? 230  VAL A C   1 
ATOM   1656 O O   . VAL A 1 211 ? -2.74541  20.89120  -16.42289 1.000 17.94707 ? 230  VAL A O   1 
ATOM   1657 C CB  . VAL A 1 211 ? -4.43180  21.46245  -13.53885 1.000 16.81574 ? 230  VAL A CB  1 
ATOM   1658 C CG1 . VAL A 1 211 ? -5.69823  21.12702  -12.74694 1.000 14.95173 ? 230  VAL A CG1 1 
ATOM   1659 C CG2 . VAL A 1 211 ? -3.25844  20.57573  -13.09732 1.000 17.41834 ? 230  VAL A CG2 1 
ATOM   1660 N N   . SER A 1 212 ? -3.22691  23.02060  -15.87365 1.000 16.23301 ? 231  SER A N   1 
ATOM   1661 C CA  . SER A 1 212 ? -2.04418  23.57171  -16.51400 1.000 21.34408 ? 231  SER A CA  1 
ATOM   1662 C C   . SER A 1 212 ? -0.79113  23.27775  -15.68541 1.000 18.52461 ? 231  SER A C   1 
ATOM   1663 O O   . SER A 1 212 ? -0.86021  22.98648  -14.48594 1.000 18.25259 ? 231  SER A O   1 
ATOM   1664 C CB  . SER A 1 212 ? -2.23064  25.07780  -16.72406 1.000 20.31766 ? 231  SER A CB  1 
ATOM   1665 O OG  . SER A 1 212 ? -2.05698  25.77406  -15.50456 1.000 17.47674 ? 231  SER A OG  1 
ATOM   1666 N N   . PHE A 1 213 ? 0.36672   23.33559  -16.35818 1.000 16.88419 ? 232  PHE A N   1 
ATOM   1667 C CA  . PHE A 1 213 ? 1.64388   23.16440  -15.66764 1.000 17.83504 ? 232  PHE A CA  1 
ATOM   1668 C C   . PHE A 1 213 ? 1.78037   24.15719  -14.51895 1.000 16.62814 ? 232  PHE A C   1 
ATOM   1669 O O   . PHE A 1 213 ? 2.11051   23.77206  -13.38725 1.000 16.49051 ? 232  PHE A O   1 
ATOM   1670 C CB  . PHE A 1 213 ? 2.80202   23.32678  -16.65306 1.000 21.17808 ? 232  PHE A CB  1 
ATOM   1671 C CG  . PHE A 1 213 ? 4.16075   22.99470  -16.07155 1.000 21.12033 ? 232  PHE A CG  1 
ATOM   1672 C CD1 . PHE A 1 213 ? 4.35399   21.83359  -15.32895 1.000 20.21833 ? 232  PHE A CD1 1 
ATOM   1673 C CD2 . PHE A 1 213 ? 5.23975   23.85078  -16.26656 1.000 25.60775 ? 232  PHE A CD2 1 
ATOM   1674 C CE1 . PHE A 1 213 ? 5.61479   21.51885  -14.79968 1.000 23.49881 ? 232  PHE A CE1 1 
ATOM   1675 C CE2 . PHE A 1 213 ? 6.50188   23.55123  -15.74187 1.000 20.89763 ? 232  PHE A CE2 1 
ATOM   1676 C CZ  . PHE A 1 213 ? 6.68501   22.38433  -15.00361 1.000 21.56331 ? 232  PHE A CZ  1 
ATOM   1677 N N   . ASP A 1 214 ? 1.52357   25.44719  -14.78110 1.000 17.54017 ? 233  ASP A N   1 
ATOM   1678 C CA  . ASP A 1 214 ? 1.59397   26.44070  -13.70382 1.000 16.79745 ? 233  ASP A CA  1 
ATOM   1679 C C   . ASP A 1 214 ? 0.66770   26.08883  -12.54950 1.000 17.40973 ? 233  ASP A C   1 
ATOM   1680 O O   . ASP A 1 214 ? 1.05928   26.16630  -11.38083 1.000 16.88438 ? 233  ASP A O   1 
ATOM   1681 C CB  . ASP A 1 214 ? 1.26886   27.83955  -14.22862 1.000 20.07337 ? 233  ASP A CB  1 
ATOM   1682 C CG  . ASP A 1 214 ? 2.37836   28.41251  -15.08112 1.000 27.80541 ? 233  ASP A CG  1 
ATOM   1683 O OD1 . ASP A 1 214 ? 3.51164   27.88975  -15.00846 1.000 24.04178 ? 233  ASP A OD1 1 
ATOM   1684 O OD2 . ASP A 1 214 ? 2.11696   29.38875  -15.81859 1.000 22.27031 ? 233  ASP A OD2 1 
ATOM   1685 N N   . LYS A 1 215 ? -0.57803  25.70990  -12.85072 1.000 18.12912 ? 234  LYS A N   1 
ATOM   1686 C CA  . LYS A 1 215 ? -1.49551  25.35254  -11.77435 1.000 17.41121 ? 234  LYS A CA  1 
ATOM   1687 C C   . LYS A 1 215 ? -1.02119  24.09720  -11.04762 1.000 17.78217 ? 234  LYS A C   1 
ATOM   1688 O O   . LYS A 1 215 ? -1.10905  24.01401  -9.81972  1.000 15.97103 ? 234  LYS A O   1 
ATOM   1689 C CB  . LYS A 1 215 ? -2.90752  25.14614  -12.32939 1.000 20.35291 ? 234  LYS A CB  1 
ATOM   1690 C CG  . LYS A 1 215 ? -3.78926  26.40046  -12.45582 1.000 20.82278 ? 234  LYS A CG  1 
ATOM   1691 C CD  . LYS A 1 215 ? -3.89244  27.19497  -11.15961 1.000 24.41854 ? 234  LYS A CD  1 
ATOM   1692 C CE  . LYS A 1 215 ? -4.33697  28.62833  -11.46035 1.000 30.61790 ? 234  LYS A CE  1 
ATOM   1693 N NZ  . LYS A 1 215 ? -3.43103  29.37145  -12.37636 1.000 36.32747 ? 234  LYS A NZ  1 
ATOM   1694 N N   . ALA A 1 216 ? -0.53679  23.09951  -11.79359 1.000 15.58352 ? 235  ALA A N   1 
ATOM   1695 C CA  . ALA A 1 216 ? -0.04306  21.87697  -11.15910 1.000 12.98892 ? 235  ALA A CA  1 
ATOM   1696 C C   . ALA A 1 216 ? 1.03289   22.17151  -10.11378 1.000 13.59157 ? 235  ALA A C   1 
ATOM   1697 O O   . ALA A 1 216 ? 1.07209   21.53134  -9.05643  1.000 14.34486 ? 235  ALA A O   1 
ATOM   1698 C CB  . ALA A 1 216 ? 0.49159   20.92249  -12.22435 1.000 16.06489 ? 235  ALA A CB  1 
ATOM   1699 N N   . CYS A 1 217 ? 1.90998   23.14417  -10.38378 1.000 15.83248 ? 236  CYS A N   1 
ATOM   1700 C CA  . CYS A 1 217 ? 2.97689   23.44235  -9.42514  1.000 16.13578 ? 236  CYS A CA  1 
ATOM   1701 C C   . CYS A 1 217 ? 2.47347   24.26894  -8.24331  1.000 13.52984 ? 236  CYS A C   1 
ATOM   1702 O O   . CYS A 1 217 ? 2.98181   24.11424  -7.13154  1.000 16.26557 ? 236  CYS A O   1 
ATOM   1703 C CB  . CYS A 1 217 ? 4.14206   24.15128  -10.12464 1.000 18.24662 ? 236  CYS A CB  1 
ATOM   1704 S SG  . CYS A 1 217 ? 4.99866   23.15168  -11.41061 1.000 18.52425 ? 236  CYS A SG  1 
ATOM   1705 N N   . GLU A 1 218 ? 1.48549   25.14543  -8.44844  1.000 16.68794 ? 237  GLU A N   1 
ATOM   1706 C CA  . GLU A 1 218 ? 0.84803   25.81958  -7.31606  1.000 18.09303 ? 237  GLU A CA  1 
ATOM   1707 C C   . GLU A 1 218 ? 0.18421   24.81832  -6.37384  1.000 17.51196 ? 237  GLU A C   1 
ATOM   1708 O O   . GLU A 1 218 ? 0.28743   24.93039  -5.14164  1.000 15.63248 ? 237  GLU A O   1 
ATOM   1709 C CB  . GLU A 1 218 ? -0.19110  26.81752  -7.81987  1.000 18.38751 ? 237  GLU A CB  1 
ATOM   1710 C CG  . GLU A 1 218 ? 0.34438   28.01156  -8.53997  1.000 22.29172 ? 237  GLU A CG  1 
ATOM   1711 C CD  . GLU A 1 218 ? -0.79015  28.83300  -9.15492  1.000 30.05072 ? 237  GLU A CD  1 
ATOM   1712 O OE1 . GLU A 1 218 ? -1.79344  29.07556  -8.44448  1.000 28.63300 ? 237  GLU A OE1 1 
ATOM   1713 O OE2 . GLU A 1 218 ? -0.66966  29.23324  -10.33805 1.000 32.18720 ? 237  GLU A OE2 1 
ATOM   1714 N N   . PHE A 1 219 ? -0.54625  23.85626  -6.93868  1.000 15.94531 ? 238  PHE A N   1 
ATOM   1715 C CA  . PHE A 1 219 ? -1.12092  22.79043  -6.12521  1.000 15.74625 ? 238  PHE A CA  1 
ATOM   1716 C C   . PHE A 1 219 ? -0.03960  22.06683  -5.34617  1.000 14.43761 ? 238  PHE A C   1 
ATOM   1717 O O   . PHE A 1 219 ? -0.18515  21.80728  -4.14187  1.000 15.42873 ? 238  PHE A O   1 
ATOM   1718 C CB  . PHE A 1 219 ? -1.87209  21.80558  -7.01689  1.000 11.83118 ? 238  PHE A CB  1 
ATOM   1719 C CG  . PHE A 1 219 ? -3.24926  22.28136  -7.43094  1.000 15.54555 ? 238  PHE A CG  1 
ATOM   1720 C CD1 . PHE A 1 219 ? -4.22918  22.49479  -6.48957  1.000 12.30272 ? 238  PHE A CD1 1 
ATOM   1721 C CD2 . PHE A 1 219 ? -3.53881  22.52806  -8.77222  1.000 17.76793 ? 238  PHE A CD2 1 
ATOM   1722 C CE1 . PHE A 1 219 ? -5.51144  22.92728  -6.88289  1.000 16.44163 ? 238  PHE A CE1 1 
ATOM   1723 C CE2 . PHE A 1 219 ? -4.78533  22.96873  -9.16909  1.000 17.88845 ? 238  PHE A CE2 1 
ATOM   1724 C CZ  . PHE A 1 219 ? -5.77994  23.16924  -8.22339  1.000 13.94100 ? 238  PHE A CZ  1 
ATOM   1725 N N   . ALA A 1 220 ? 1.04335   21.70045  -6.03262  1.000 15.31074 ? 239  ALA A N   1 
ATOM   1726 C CA  . ALA A 1 220 ? 2.11513   20.96693  -5.37126  1.000 14.18890 ? 239  ALA A CA  1 
ATOM   1727 C C   . ALA A 1 220 ? 2.73442   21.79768  -4.26068  1.000 14.34400 ? 239  ALA A C   1 
ATOM   1728 O O   . ALA A 1 220 ? 3.19435   21.24706  -3.25615  1.000 14.21129 ? 239  ALA A O   1 
ATOM   1729 C CB  . ALA A 1 220 ? 3.17086   20.55024  -6.39913  1.000 13.24839 ? 239  ALA A CB  1 
ATOM   1730 N N   . GLY A 1 221 ? 2.71948   23.12440  -4.40460  1.000 15.15194 ? 240  GLY A N   1 
ATOM   1731 C CA  . GLY A 1 221 ? 3.24900   23.97118  -3.34784  1.000 14.54918 ? 240  GLY A CA  1 
ATOM   1732 C C   . GLY A 1 221 ? 2.42504   23.90231  -2.07660  1.000 15.59297 ? 240  GLY A C   1 
ATOM   1733 O O   . GLY A 1 221 ? 2.97734   23.82287  -0.97952  1.000 16.54203 ? 240  GLY A O   1 
ATOM   1734 N N   . PHE A 1 222 ? 1.09301   23.94820  -2.20172  1.000 17.03868 ? 241  PHE A N   1 
ATOM   1735 C CA  . PHE A 1 222 ? 0.23846   23.67342  -1.05005  1.000 14.89207 ? 241  PHE A CA  1 
ATOM   1736 C C   . PHE A 1 222 ? 0.45772   22.26192  -0.54078  1.000 16.63636 ? 241  PHE A C   1 
ATOM   1737 O O   . PHE A 1 222 ? 0.46665   22.02540  0.67424   1.000 18.20120 ? 241  PHE A O   1 
ATOM   1738 C CB  . PHE A 1 222 ? -1.24144  23.84253  -1.40703  1.000 15.55582 ? 241  PHE A CB  1 
ATOM   1739 C CG  . PHE A 1 222 ? -1.64864  25.25154  -1.68301  1.000 17.11131 ? 241  PHE A CG  1 
ATOM   1740 C CD1 . PHE A 1 222 ? -1.42549  26.25293  -0.74237  1.000 21.28555 ? 241  PHE A CD1 1 
ATOM   1741 C CD2 . PHE A 1 222 ? -2.24721  25.58374  -2.89070  1.000 20.01527 ? 241  PHE A CD2 1 
ATOM   1742 C CE1 . PHE A 1 222 ? -1.80020  27.57047  -1.00065  1.000 22.60798 ? 241  PHE A CE1 1 
ATOM   1743 C CE2 . PHE A 1 222 ? -2.63046  26.89363  -3.15365  1.000 22.69967 ? 241  PHE A CE2 1 
ATOM   1744 C CZ  . PHE A 1 222 ? -2.40693  27.89018  -2.20529  1.000 22.14127 ? 241  PHE A CZ  1 
ATOM   1745 N N   . GLN A 1 223 ? 0.58152   21.29645  -1.46224  1.000 14.84943 ? 242  GLN A N   1 
ATOM   1746 C CA  . GLN A 1 223 ? 0.82845   19.92525  -1.03290  1.000 13.44231 ? 242  GLN A CA  1 
ATOM   1747 C C   . GLN A 1 223 ? 2.08033   19.85662  -0.17023  1.000 16.10180 ? 242  GLN A C   1 
ATOM   1748 O O   . GLN A 1 223 ? 2.09142   19.17435  0.85890   1.000 18.25126 ? 242  GLN A O   1 
ATOM   1749 C CB  . GLN A 1 223 ? 0.94910   18.99396  -2.25037  1.000 14.90672 ? 242  GLN A CB  1 
ATOM   1750 C CG  . GLN A 1 223 ? 0.84068   17.49053  -1.89082  1.000 16.15639 ? 242  GLN A CG  1 
ATOM   1751 C CD  . GLN A 1 223 ? 1.08446   16.60043  -3.10690  1.000 15.26562 ? 242  GLN A CD  1 
ATOM   1752 O OE1 . GLN A 1 223 ? 0.93889   17.04346  -4.24226  1.000 15.19443 ? 242  GLN A OE1 1 
ATOM   1753 N NE2 . GLN A 1 223 ? 1.45036   15.35091  -2.86911  1.000 16.05520 ? 242  GLN A NE2 1 
ATOM   1754 N N   . CYS A 1 224 ? 3.14038   20.56955  -0.56870  1.000 15.90826 ? 243  CYS A N   1 
ATOM   1755 C CA  . CYS A 1 224 ? 4.36324   20.57785  0.23244   1.000 17.44418 ? 243  CYS A CA  1 
ATOM   1756 C C   . CYS A 1 224 ? 4.11335   21.17170  1.60925   1.000 18.83258 ? 243  CYS A C   1 
ATOM   1757 O O   . CYS A 1 224 ? 4.59844   20.64657  2.62285   1.000 17.60496 ? 243  CYS A O   1 
ATOM   1758 C CB  . CYS A 1 224 ? 5.46985   21.35284  -0.47419  1.000 17.98874 ? 243  CYS A CB  1 
ATOM   1759 S SG  . CYS A 1 224 ? 6.27334   20.47043  -1.82921  1.000 16.97048 ? 243  CYS A SG  1 
ATOM   1760 N N   . GLN A 1 225 ? 3.38387   22.28333  1.66324   1.000 17.22789 ? 244  GLN A N   1 
ATOM   1761 C CA  . GLN A 1 225 ? 3.07695   22.87366  2.95753   1.000 17.70061 ? 244  GLN A CA  1 
ATOM   1762 C C   . GLN A 1 225 ? 2.37484   21.85926  3.84881   1.000 20.55464 ? 244  GLN A C   1 
ATOM   1763 O O   . GLN A 1 225 ? 2.70262   21.72305  5.03204   1.000 20.21907 ? 244  GLN A O   1 
ATOM   1764 C CB  . GLN A 1 225 ? 2.22478   24.13076  2.77127   1.000 18.60562 ? 244  GLN A CB  1 
ATOM   1765 C CG  . GLN A 1 225 ? 2.05964   24.93866  4.05508   1.000 23.41483 ? 244  GLN A CG  1 
ATOM   1766 C CD  . GLN A 1 225 ? 3.26473   25.82788  4.30667   1.000 24.75909 ? 244  GLN A CD  1 
ATOM   1767 O OE1 . GLN A 1 225 ? 4.20911   25.84640  3.51158   1.000 22.18918 ? 244  GLN A OE1 1 
ATOM   1768 N NE2 . GLN A 1 225 ? 3.23373   26.58165  5.40532   1.000 22.04395 ? 244  GLN A NE2 1 
ATOM   1769 N N   . ILE A 1 226 ? 1.45057   21.08696  3.27697   1.000 22.62962 ? 245  ILE A N   1 
ATOM   1770 C CA  . ILE A 1 226 ? 0.67335   20.14593  4.07291   1.000 18.69182 ? 245  ILE A CA  1 
ATOM   1771 C C   . ILE A 1 226 ? 1.53809   18.98016  4.54383   1.000 21.21662 ? 245  ILE A C   1 
ATOM   1772 O O   . ILE A 1 226 ? 1.40235   18.50298  5.68051   1.000 22.16021 ? 245  ILE A O   1 
ATOM   1773 C CB  . ILE A 1 226 ? -0.54431  19.66495  3.25654   1.000 19.81432 ? 245  ILE A CB  1 
ATOM   1774 C CG1 . ILE A 1 226 ? -1.58307  20.78090  3.16374   1.000 18.68113 ? 245  ILE A CG1 1 
ATOM   1775 C CG2 . ILE A 1 226 ? -1.18197  18.41593  3.87920   1.000 20.43981 ? 245  ILE A CG2 1 
ATOM   1776 C CD1 . ILE A 1 226 ? -2.38689  20.75478  1.86221   1.000 19.05889 ? 245  ILE A CD1 1 
ATOM   1777 N N   . GLN A 1 227 ? 2.42745   18.48239  3.68732   1.000 21.10208 ? 246  GLN A N   1 
ATOM   1778 C CA  . GLN A 1 227 ? 3.16434   17.28513  4.06972   1.000 21.19763 ? 246  GLN A CA  1 
ATOM   1779 C C   . GLN A 1 227 ? 4.40756   17.59474  4.88579   1.000 24.44041 ? 246  GLN A C   1 
ATOM   1780 O O   . GLN A 1 227 ? 4.78672   16.79469  5.74751   1.000 22.39669 ? 246  GLN A O   1 
ATOM   1781 C CB  . GLN A 1 227 ? 3.53721   16.46895  2.82873   1.000 23.78832 ? 246  GLN A CB  1 
ATOM   1782 C CG  . GLN A 1 227 ? 2.31249   15.99782  2.06208   1.000 23.58785 ? 246  GLN A CG  1 
ATOM   1783 C CD  . GLN A 1 227 ? 2.62835   15.07018  0.91253   1.000 23.15629 ? 246  GLN A CD  1 
ATOM   1784 O OE1 . GLN A 1 227 ? 1.78865   14.85033  0.04838   1.000 20.86473 ? 246  GLN A OE1 1 
ATOM   1785 N NE2 . GLN A 1 227 ? 3.83996   14.52381  0.89331   1.000 20.94522 ? 246  GLN A NE2 1 
ATOM   1786 N N   . PHE A 1 228 ? 5.02337   18.75058  4.66763   1.000 22.54697 ? 247  PHE A N   1 
ATOM   1787 C CA  . PHE A 1 228 ? 6.32226   19.04941  5.25278   1.000 23.94908 ? 247  PHE A CA  1 
ATOM   1788 C C   . PHE A 1 228 ? 6.32386   20.23793  6.20391   1.000 29.32902 ? 247  PHE A C   1 
ATOM   1789 O O   . PHE A 1 228 ? 7.35476   20.49547  6.84209   1.000 25.66305 ? 247  PHE A O   1 
ATOM   1790 C CB  . PHE A 1 228 ? 7.35669   19.30789  4.14342   1.000 21.58123 ? 247  PHE A CB  1 
ATOM   1791 C CG  . PHE A 1 228 ? 7.41098   18.22009  3.10598   1.000 19.39110 ? 247  PHE A CG  1 
ATOM   1792 C CD1 . PHE A 1 228 ? 7.72433   16.91852  3.46613   1.000 23.63770 ? 247  PHE A CD1 1 
ATOM   1793 C CD2 . PHE A 1 228 ? 7.17560   18.50264  1.76665   1.000 20.51709 ? 247  PHE A CD2 1 
ATOM   1794 C CE1 . PHE A 1 228 ? 7.78290   15.91475  2.51173   1.000 24.36759 ? 247  PHE A CE1 1 
ATOM   1795 C CE2 . PHE A 1 228 ? 7.23051   17.49548  0.80849   1.000 18.49212 ? 247  PHE A CE2 1 
ATOM   1796 C CZ  . PHE A 1 228 ? 7.52887   16.20624  1.18101   1.000 18.76222 ? 247  PHE A CZ  1 
ATOM   1797 N N   . GLY A 1 229 ? 5.22180   20.97102  6.31898   1.000 25.75542 ? 248  GLY A N   1 
ATOM   1798 C CA  . GLY A 1 229 ? 5.24404   22.21357  7.04706   1.000 25.01354 ? 248  GLY A CA  1 
ATOM   1799 C C   . GLY A 1 229 ? 5.88701   23.31462  6.22712   1.000 23.24635 ? 248  GLY A C   1 
ATOM   1800 O O   . GLY A 1 229 ? 6.18877   23.14580  5.03961   1.000 22.47336 ? 248  GLY A O   1 
ATOM   1801 N N   . PRO A 1 230 ? 6.11316   24.47002  6.85507   1.000 25.79539 ? 249  PRO A N   1 
ATOM   1802 C CA  . PRO A 1 230 ? 6.66543   25.61962  6.12594   1.000 22.18165 ? 249  PRO A CA  1 
ATOM   1803 C C   . PRO A 1 230 ? 7.98967   25.28267  5.45434   1.000 23.26682 ? 249  PRO A C   1 
ATOM   1804 O O   . PRO A 1 230 ? 8.73741   24.41744  5.91181   1.000 24.57811 ? 249  PRO A O   1 
ATOM   1805 C CB  . PRO A 1 230 ? 6.84901   26.67399  7.22395   1.000 27.78260 ? 249  PRO A CB  1 
ATOM   1806 C CG  . PRO A 1 230 ? 5.79267   26.31476  8.24220   1.000 22.99373 ? 249  PRO A CG  1 
ATOM   1807 C CD  . PRO A 1 230 ? 5.77679   24.80475  8.24982   1.000 28.33082 ? 249  PRO A CD  1 
ATOM   1808 N N   . HIS A 1 231 ? 8.24875   25.95499  4.33571   1.000 21.50616 ? 250  HIS A N   1 
ATOM   1809 C CA  . HIS A 1 231 ? 9.42495   25.66352  3.53118   1.000 23.27957 ? 250  HIS A CA  1 
ATOM   1810 C C   . HIS A 1 231 ? 10.70413  26.00371  4.28431   1.000 29.72292 ? 250  HIS A C   1 
ATOM   1811 O O   . HIS A 1 231 ? 10.80329  27.03022  4.96251   1.000 26.88452 ? 250  HIS A O   1 
ATOM   1812 C CB  . HIS A 1 231 ? 9.35849   26.41617  2.20629   1.000 21.12616 ? 250  HIS A CB  1 
ATOM   1813 C CG  . HIS A 1 231 ? 10.51980  26.15719  1.29615   1.000 27.83061 ? 250  HIS A CG  1 
ATOM   1814 N ND1 . HIS A 1 231 ? 10.47426  25.23723  0.26807   1.000 23.26910 ? 250  HIS A ND1 1 
ATOM   1815 C CD2 . HIS A 1 231 ? 11.72629  26.76655  1.20012   1.000 31.20845 ? 250  HIS A CD2 1 
ATOM   1816 C CE1 . HIS A 1 231 ? 11.62363  25.25139  -0.38458  1.000 27.73247 ? 250  HIS A CE1 1 
ATOM   1817 N NE2 . HIS A 1 231 ? 12.39888  26.17505  0.15769   1.000 29.03398 ? 250  HIS A NE2 1 
ATOM   1818 N N   . ASN A 1 232 ? 11.68827  25.12699  4.16661   1.000 28.49738 ? 251  ASN A N   1 
ATOM   1819 C CA  . ASN A 1 232 ? 12.92394  25.25022  4.92805   1.000 29.00581 ? 251  ASN A CA  1 
ATOM   1820 C C   . ASN A 1 232 ? 14.05212  25.02743  3.93006   1.000 31.55254 ? 251  ASN A C   1 
ATOM   1821 O O   . ASN A 1 232 ? 14.28018  23.89169  3.49963   1.000 31.26727 ? 251  ASN A O   1 
ATOM   1822 C CB  . ASN A 1 232 ? 12.94181  24.23032  6.07118   1.000 29.15675 ? 251  ASN A CB  1 
ATOM   1823 C CG  . ASN A 1 232 ? 14.29816  24.10823  6.76142   1.000 40.34637 ? 251  ASN A CG  1 
ATOM   1824 O OD1 . ASN A 1 232 ? 15.35637  24.26622  6.16150   1.000 34.95559 ? 251  ASN A OD1 1 
ATOM   1825 N ND2 . ASN A 1 232 ? 14.25187  23.81132  8.05365   1.000 46.07213 ? 251  ASN A ND2 1 
ATOM   1826 N N   . GLU A 1 233 ? 14.75535  26.10433  3.56164   1.000 33.21026 ? 252  GLU A N   1 
ATOM   1827 C CA  . GLU A 1 233 ? 15.79366  26.00686  2.53723   1.000 38.36616 ? 252  GLU A CA  1 
ATOM   1828 C C   . GLU A 1 233 ? 16.95204  25.09463  2.90950   1.000 39.80874 ? 252  GLU A C   1 
ATOM   1829 O O   . GLU A 1 233 ? 17.76385  24.79383  2.03078   1.000 43.63853 ? 252  GLU A O   1 
ATOM   1830 C CB  . GLU A 1 233 ? 16.37571  27.37572  2.17223   1.000 42.31348 ? 252  GLU A CB  1 
ATOM   1831 C CG  . GLU A 1 233 ? 15.54743  28.18890  1.20456   1.000 47.73933 ? 252  GLU A CG  1 
ATOM   1832 C CD  . GLU A 1 233 ? 15.38138  29.62909  1.62819   1.000 59.02993 ? 252  GLU A CD  1 
ATOM   1833 O OE1 . GLU A 1 233 ? 15.99695  30.02081  2.64359   1.000 63.58060 ? 252  GLU A OE1 1 
ATOM   1834 O OE2 . GLU A 1 233 ? 14.65464  30.37107  0.92728   1.000 57.76207 ? 252  GLU A OE2 1 
ATOM   1835 N N   . GLN A 1 234 ? 17.06967  24.65538  4.16327   1.000 40.25959 ? 253  GLN A N   1 
ATOM   1836 C CA  . GLN A 1 234 ? 18.12520  23.69768  4.48044   1.000 39.62241 ? 253  GLN A CA  1 
ATOM   1837 C C   . GLN A 1 234 ? 17.76964  22.29805  3.99266   1.000 42.97570 ? 253  GLN A C   1 
ATOM   1838 O O   . GLN A 1 234 ? 18.63470  21.58078  3.47954   1.000 44.80915 ? 253  GLN A O   1 
ATOM   1839 C CB  . GLN A 1 234 ? 18.40891  23.67647  5.98649   1.000 43.26367 ? 253  GLN A CB  1 
ATOM   1840 C CG  . GLN A 1 234 ? 18.39888  25.04257  6.68064   1.000 46.13780 ? 253  GLN A CG  1 
ATOM   1841 C CD  . GLN A 1 234 ? 19.38440  26.02621  6.06728   1.000 49.24915 ? 253  GLN A CD  1 
ATOM   1842 O OE1 . GLN A 1 234 ? 18.99429  27.02674  5.46406   1.000 51.34735 ? 253  GLN A OE1 1 
ATOM   1843 N NE2 . GLN A 1 234 ? 20.67385  25.75160  6.23620   1.000 48.26069 ? 253  GLN A NE2 1 
ATOM   1844 N N   . LYS A 1 235 ? 16.50847  21.89142  4.13265   1.000 36.32394 ? 254  LYS A N   1 
ATOM   1845 C CA  . LYS A 1 235 ? 16.10501  20.53198  3.79874   1.000 37.30423 ? 254  LYS A CA  1 
ATOM   1846 C C   . LYS A 1 235 ? 15.35304  20.43065  2.47818   1.000 37.06141 ? 254  LYS A C   1 
ATOM   1847 O O   . LYS A 1 235 ? 15.43904  19.39641  1.80681   1.000 37.13778 ? 254  LYS A O   1 
ATOM   1848 C CB  . LYS A 1 235 ? 15.26517  19.94392  4.95207   1.000 35.75483 ? 254  LYS A CB  1 
ATOM   1849 C CG  . LYS A 1 235 ? 14.39991  18.70185  4.65058   1.000 41.17980 ? 254  LYS A CG  1 
ATOM   1850 C CD  . LYS A 1 235 ? 13.58773  18.27592  5.90828   1.000 40.16450 ? 254  LYS A CD  1 
ATOM   1851 C CE  . LYS A 1 235 ? 12.39797  17.31691  5.63987   1.000 42.38379 ? 254  LYS A CE  1 
ATOM   1852 N NZ  . LYS A 1 235 ? 11.07334  17.95377  5.29378   1.000 31.01057 ? 254  LYS A NZ  1 
ATOM   1853 N N   . HIS A 1 236 ? 14.66343  21.48691  2.06097   1.000 30.25117 ? 255  HIS A N   1 
ATOM   1854 C CA  . HIS A 1 236 ? 13.82962  21.44368  0.85976   1.000 28.16615 ? 255  HIS A CA  1 
ATOM   1855 C C   . HIS A 1 236 ? 14.58020  22.08494  -0.30707  1.000 30.74044 ? 255  HIS A C   1 
ATOM   1856 O O   . HIS A 1 236 ? 14.26327  23.17459  -0.78617  1.000 32.34376 ? 255  HIS A O   1 
ATOM   1857 C CB  . HIS A 1 236 ? 12.49510  22.12226  1.14098   1.000 26.85830 ? 255  HIS A CB  1 
ATOM   1858 C CG  . HIS A 1 236 ? 11.80959  21.57667  2.35128   1.000 27.00895 ? 255  HIS A CG  1 
ATOM   1859 N ND1 . HIS A 1 236 ? 11.03862  22.35165  3.18912   1.000 23.55082 ? 255  HIS A ND1 1 
ATOM   1860 C CD2 . HIS A 1 236 ? 11.76735  20.32108  2.85524   1.000 23.36253 ? 255  HIS A CD2 1 
ATOM   1861 C CE1 . HIS A 1 236 ? 10.56481  21.60066  4.16660   1.000 28.01082 ? 255  HIS A CE1 1 
ATOM   1862 N NE2 . HIS A 1 236 ? 10.99027  20.36357  3.98506   1.000 25.32042 ? 255  HIS A NE2 1 
ATOM   1863 N N   . LYS A 1 237 ? 15.59463  21.35827  -0.76683  1.000 31.92792 ? 256  LYS A N   1 
ATOM   1864 C CA  . LYS A 1 237 ? 16.54363  21.81052  -1.77246  1.000 32.66272 ? 256  LYS A CA  1 
ATOM   1865 C C   . LYS A 1 237 ? 16.45242  20.91569  -3.00300  1.000 24.48449 ? 256  LYS A C   1 
ATOM   1866 O O   . LYS A 1 237 ? 15.75352  19.89931  -3.00419  1.000 21.64815 ? 256  LYS A O   1 
ATOM   1867 C CB  . LYS A 1 237 ? 17.96584  21.80528  -1.19781  1.000 32.92001 ? 256  LYS A CB  1 
ATOM   1868 C CG  . LYS A 1 237 ? 18.30316  20.51320  -0.45625  1.000 35.33762 ? 256  LYS A CG  1 
ATOM   1869 C CD  . LYS A 1 237 ? 19.70924  20.54849  0.16759   1.000 42.18659 ? 256  LYS A CD  1 
ATOM   1870 C CE  . LYS A 1 237 ? 20.03488  19.23260  0.88148   1.000 40.44388 ? 256  LYS A CE  1 
ATOM   1871 N NZ  . LYS A 1 237 ? 20.30360  18.09866  -0.06804  1.000 42.36365 ? 256  LYS A NZ  1 
ATOM   1872 N N   . ALA A 1 238 ? 17.17229  21.30680  -4.05365  1.000 24.91832 ? 257  ALA A N   1 
ATOM   1873 C CA  . ALA A 1 238 ? 17.08941  20.61333  -5.33226  1.000 26.23119 ? 257  ALA A CA  1 
ATOM   1874 C C   . ALA A 1 238 ? 17.25242  19.10941  -5.14315  1.000 23.77702 ? 257  ALA A C   1 
ATOM   1875 O O   . ALA A 1 238 ? 18.15849  18.65077  -4.43337  1.000 19.70097 ? 257  ALA A O   1 
ATOM   1876 C CB  . ALA A 1 238 ? 18.15467  21.14162  -6.29507  1.000 27.42274 ? 257  ALA A CB  1 
ATOM   1877 N N   . GLY A 1 239 ? 16.35275  18.34816  -5.77048  1.000 22.11258 ? 258  GLY A N   1 
ATOM   1878 C CA  . GLY A 1 239 ? 16.38379  16.89852  -5.71119  1.000 22.51375 ? 258  GLY A CA  1 
ATOM   1879 C C   . GLY A 1 239 ? 15.57704  16.28351  -4.58830  1.000 17.54710 ? 258  GLY A C   1 
ATOM   1880 O O   . GLY A 1 239 ? 15.35411  15.06793  -4.60024  1.000 17.97767 ? 258  GLY A O   1 
ATOM   1881 N N   . PHE A 1 240 ? 15.09992  17.08448  -3.63480  1.000 19.74332 ? 259  PHE A N   1 
ATOM   1882 C CA  . PHE A 1 240 ? 14.45617  16.51547  -2.45744  1.000 20.65065 ? 259  PHE A CA  1 
ATOM   1883 C C   . PHE A 1 240 ? 13.13747  15.83060  -2.82074  1.000 18.64936 ? 259  PHE A C   1 
ATOM   1884 O O   . PHE A 1 240 ? 12.85217  14.72899  -2.33498  1.000 19.20804 ? 259  PHE A O   1 
ATOM   1885 C CB  . PHE A 1 240 ? 14.26562  17.62105  -1.41371  1.000 22.39512 ? 259  PHE A CB  1 
ATOM   1886 C CG  . PHE A 1 240 ? 13.32643  17.26742  -0.30982  1.000 24.92232 ? 259  PHE A CG  1 
ATOM   1887 C CD1 . PHE A 1 240 ? 13.77648  16.51906  0.76761   1.000 26.23566 ? 259  PHE A CD1 1 
ATOM   1888 C CD2 . PHE A 1 240 ? 12.01422  17.71051  -0.31882  1.000 24.50882 ? 259  PHE A CD2 1 
ATOM   1889 C CE1 . PHE A 1 240 ? 12.92645  16.18945  1.80781   1.000 27.16610 ? 259  PHE A CE1 1 
ATOM   1890 C CE2 . PHE A 1 240 ? 11.15661  17.38915  0.71478   1.000 24.01530 ? 259  PHE A CE2 1 
ATOM   1891 C CZ  . PHE A 1 240 ? 11.61022  16.62516  1.78082   1.000 26.69864 ? 259  PHE A CZ  1 
ATOM   1892 N N   . LEU A 1 241 ? 12.35180  16.42580  -3.72340  1.000 18.57557 ? 260  LEU A N   1 
ATOM   1893 C CA  . LEU A 1 241 ? 10.99727  15.94628  -3.98753  1.000 16.62775 ? 260  LEU A CA  1 
ATOM   1894 C C   . LEU A 1 241 ? 11.01985  14.73424  -4.91210  1.000 18.19639 ? 260  LEU A C   1 
ATOM   1895 O O   . LEU A 1 241 ? 11.72335  14.73799  -5.92444  1.000 15.17015 ? 260  LEU A O   1 
ATOM   1896 C CB  . LEU A 1 241 ? 10.16894  17.05152  -4.64346  1.000 17.28568 ? 260  LEU A CB  1 
ATOM   1897 C CG  . LEU A 1 241 ? 9.64193   18.19524  -3.77136  1.000 22.65935 ? 260  LEU A CG  1 
ATOM   1898 C CD1 . LEU A 1 241 ? 8.74853   19.07871  -4.63265  1.000 18.96812 ? 260  LEU A CD1 1 
ATOM   1899 C CD2 . LEU A 1 241 ? 8.90369   17.70596  -2.51271  1.000 18.80593 ? 260  LEU A CD2 1 
ATOM   1900 N N   . ASP A 1 242 ? 10.23191  13.70525  -4.58364  1.000 16.57586 ? 261  ASP A N   1 
ATOM   1901 C CA  . ASP A 1 242 ? 9.91003   12.68216  -5.58658  1.000 17.38927 ? 261  ASP A CA  1 
ATOM   1902 C C   . ASP A 1 242 ? 8.75784   13.22927  -6.42558  1.000 15.10447 ? 261  ASP A C   1 
ATOM   1903 O O   . ASP A 1 242 ? 7.58733   13.12071  -6.05910  1.000 16.88176 ? 261  ASP A O   1 
ATOM   1904 C CB  . ASP A 1 242 ? 9.55907   11.34769  -4.94223  1.000 21.28065 ? 261  ASP A CB  1 
ATOM   1905 C CG  . ASP A 1 242 ? 10.61413  10.87319  -3.95396  1.000 29.93322 ? 261  ASP A CG  1 
ATOM   1906 O OD1 . ASP A 1 242 ? 10.27433  10.05036  -3.07317  1.000 42.82917 ? 261  ASP A OD1 1 
ATOM   1907 O OD2 . ASP A 1 242 ? 11.77380  11.31329  -4.05783  1.000 32.52610 ? 261  ASP A OD2 1 
ATOM   1908 N N   . LEU A 1 243 ? 9.10174   13.83139  -7.56859  1.000 14.39541 ? 262  LEU A N   1 
ATOM   1909 C CA  . LEU A 1 243 ? 8.13441   14.63716  -8.31430  1.000 15.00419 ? 262  LEU A CA  1 
ATOM   1910 C C   . LEU A 1 243 ? 6.95062   13.83521  -8.83485  1.000 14.71385 ? 262  LEU A C   1 
ATOM   1911 O O   . LEU A 1 243 ? 5.88247   14.42337  -9.06410  1.000 15.93621 ? 262  LEU A O   1 
ATOM   1912 C CB  . LEU A 1 243 ? 8.82656   15.37286  -9.47085  1.000 17.03444 ? 262  LEU A CB  1 
ATOM   1913 C CG  . LEU A 1 243 ? 9.74684   16.53006  -9.07884  1.000 16.10979 ? 262  LEU A CG  1 
ATOM   1914 C CD1 . LEU A 1 243 ? 10.39089  17.14255  -10.31365 1.000 18.21110 ? 262  LEU A CD1 1 
ATOM   1915 C CD2 . LEU A 1 243 ? 8.95465   17.62460  -8.33706  1.000 15.04960 ? 262  LEU A CD2 1 
ATOM   1916 N N   . LYS A 1 244 ? 7.09124   12.50993  -8.98816  1.000 16.51181 ? 263  LYS A N   1 
ATOM   1917 C CA  . LYS A 1 244 ? 5.95654   11.68183  -9.38212  1.000 18.95648 ? 263  LYS A CA  1 
ATOM   1918 C C   . LYS A 1 244 ? 4.83311   11.69741  -8.34989  1.000 19.20466 ? 263  LYS A C   1 
ATOM   1919 O O   . LYS A 1 244 ? 3.68231   11.40251  -8.70186  1.000 20.76943 ? 263  LYS A O   1 
ATOM   1920 C CB  . LYS A 1 244 ? 6.42169   10.24109  -9.65581  1.000 20.53974 ? 263  LYS A CB  1 
ATOM   1921 C CG  . LYS A 1 244 ? 6.87308   9.49183   -8.40626  1.000 22.58021 ? 263  LYS A CG  1 
ATOM   1922 C CD  . LYS A 1 244 ? 6.85784   7.97903   -8.57667  1.000 27.88560 ? 263  LYS A CD  1 
ATOM   1923 C CE  . LYS A 1 244 ? 7.33191   7.31464   -7.29638  1.000 36.36429 ? 263  LYS A CE  1 
ATOM   1924 N NZ  . LYS A 1 244 ? 6.21401   7.11608   -6.32697  1.000 42.03041 ? 263  LYS A NZ  1 
ATOM   1925 N N   . ASP A 1 245 ? 5.12116   12.04382  -7.09475  1.000 15.97692 ? 264  ASP A N   1 
ATOM   1926 C CA  . ASP A 1 245 ? 4.07843   12.11167  -6.07546  1.000 17.93052 ? 264  ASP A CA  1 
ATOM   1927 C C   . ASP A 1 245 ? 3.47003   13.50555  -5.92136  1.000 17.22530 ? 264  ASP A C   1 
ATOM   1928 O O   . ASP A 1 245 ? 2.55606   13.67518  -5.10668  1.000 15.78917 ? 264  ASP A O   1 
ATOM   1929 C CB  . ASP A 1 245 ? 4.61999   11.63681  -4.72537  1.000 17.43784 ? 264  ASP A CB  1 
ATOM   1930 C CG  . ASP A 1 245 ? 5.15026   10.20171  -4.78587  1.000 26.58685 ? 264  ASP A CG  1 
ATOM   1931 O OD1 . ASP A 1 245 ? 4.47797   9.35430   -5.40930  1.000 25.78206 ? 264  ASP A OD1 1 
ATOM   1932 O OD2 . ASP A 1 245 ? 6.22831   9.93711   -4.22712  1.000 25.35194 ? 264  ASP A OD2 1 
ATOM   1933 N N   . PHE A 1 246 ? 3.94525   14.49375  -6.68109  1.000 16.98687 ? 265  PHE A N   1 
ATOM   1934 C CA  . PHE A 1 246 ? 3.50870   15.87274  -6.53265  1.000 14.29836 ? 265  PHE A CA  1 
ATOM   1935 C C   . PHE A 1 246 ? 2.98656   16.48853  -7.81524  1.000 14.27139 ? 265  PHE A C   1 
ATOM   1936 O O   . PHE A 1 246 ? 2.43502   17.59763  -7.76964  1.000 13.75195 ? 265  PHE A O   1 
ATOM   1937 C CB  . PHE A 1 246 ? 4.66215   16.74129  -6.00710  1.000 15.34689 ? 265  PHE A CB  1 
ATOM   1938 C CG  . PHE A 1 246 ? 4.97965   16.47536  -4.57656  1.000 16.49064 ? 265  PHE A CG  1 
ATOM   1939 C CD1 . PHE A 1 246 ? 5.85768   15.45213  -4.23114  1.000 18.37040 ? 265  PHE A CD1 1 
ATOM   1940 C CD2 . PHE A 1 246 ? 4.37983   17.22192  -3.57005  1.000 15.44435 ? 265  PHE A CD2 1 
ATOM   1941 C CE1 . PHE A 1 246 ? 6.14680   15.18332  -2.88787  1.000 18.41028 ? 265  PHE A CE1 1 
ATOM   1942 C CE2 . PHE A 1 246 ? 4.65959   16.96586  -2.22878  1.000 17.99416 ? 265  PHE A CE2 1 
ATOM   1943 C CZ  . PHE A 1 246 ? 5.54094   15.94080  -1.88813  1.000 19.57327 ? 265  PHE A CZ  1 
ATOM   1944 N N   . LEU A 1 247 ? 3.11920   15.81143  -8.94545  1.000 17.78585 ? 266  LEU A N   1 
ATOM   1945 C CA  . LEU A 1 247 ? 2.72900   16.38626  -10.21815 1.000 13.94295 ? 266  LEU A CA  1 
ATOM   1946 C C   . LEU A 1 247 ? 2.01065   15.32750  -11.03658 1.000 16.32607 ? 266  LEU A C   1 
ATOM   1947 O O   . LEU A 1 247 ? 2.34986   14.14012  -10.94993 1.000 17.27115 ? 266  LEU A O   1 
ATOM   1948 C CB  . LEU A 1 247 ? 3.94518   16.88069  -11.02026 1.000 16.19617 ? 266  LEU A CB  1 
ATOM   1949 C CG  . LEU A 1 247 ? 4.66159   18.11526  -10.47693 1.000 18.05161 ? 266  LEU A CG  1 
ATOM   1950 C CD1 . LEU A 1 247 ? 5.99974   18.32188  -11.19289 1.000 15.45390 ? 266  LEU A CD1 1 
ATOM   1951 C CD2 . LEU A 1 247 ? 3.75729   19.34765  -10.57279 1.000 17.66782 ? 266  LEU A CD2 1 
ATOM   1952 N N   . PRO A 1 248 ? 1.02017   15.72763  -11.83532 1.000 16.29589 ? 267  PRO A N   1 
ATOM   1953 C CA  . PRO A 1 248 ? 0.45320   14.81558  -12.83097 1.000 17.64099 ? 267  PRO A CA  1 
ATOM   1954 C C   . PRO A 1 248 ? 1.57045   14.25024  -13.70083 1.000 15.82355 ? 267  PRO A C   1 
ATOM   1955 O O   . PRO A 1 248 ? 2.55935   14.93309  -13.97894 1.000 18.40578 ? 267  PRO A O   1 
ATOM   1956 C CB  . PRO A 1 248 ? -0.47776  15.72101  -13.64719 1.000 20.39390 ? 267  PRO A CB  1 
ATOM   1957 C CG  . PRO A 1 248 ? -0.83836  16.84608  -12.72400 1.000 20.05177 ? 267  PRO A CG  1 
ATOM   1958 C CD  . PRO A 1 248 ? 0.40947   17.07152  -11.89193 1.000 17.07722 ? 267  PRO A CD  1 
ATOM   1959 N N   . LYS A 1 249 ? 1.39039   13.00143  -14.14673 1.000 17.24875 ? 268  LYS A N   1 
ATOM   1960 C CA  . LYS A 1 249 ? 2.42679   12.29691  -14.91566 1.000 18.64365 ? 268  LYS A CA  1 
ATOM   1961 C C   . LYS A 1 249 ? 2.98343   13.13116  -16.06765 1.000 22.27217 ? 268  LYS A C   1 
ATOM   1962 O O   . LYS A 1 249 ? 4.20024   13.13797  -16.30796 1.000 18.12066 ? 268  LYS A O   1 
ATOM   1963 C CB  . LYS A 1 249 ? 1.87073   10.97319  -15.44658 1.000 23.89023 ? 268  LYS A CB  1 
ATOM   1964 C CG  . LYS A 1 249 ? 2.87760   10.11380  -16.19514 0.000 26.71088 ? 268  LYS A CG  1 
ATOM   1965 C CD  . LYS A 1 249 ? 2.27093   8.78119   -16.61661 0.000 28.37337 ? 268  LYS A CD  1 
ATOM   1966 C CE  . LYS A 1 249 ? 2.62261   7.66272   -15.64730 0.000 30.60125 ? 268  LYS A CE  1 
ATOM   1967 N NZ  . LYS A 1 249 ? 2.17896   7.95282   -14.25655 0.000 31.80067 ? 268  LYS A NZ  1 
ATOM   1968 N N   . GLU A 1 250 ? 2.11058   13.82981  -16.80631 1.000 21.24414 ? 269  GLU A N   1 
ATOM   1969 C CA  . GLU A 1 250 ? 2.56406   14.61178  -17.95883 1.000 21.31441 ? 269  GLU A CA  1 
ATOM   1970 C C   . GLU A 1 250 ? 3.54304   15.70532  -17.56281 1.000 20.35769 ? 269  GLU A C   1 
ATOM   1971 O O   . GLU A 1 250 ? 4.22605   16.25998  -18.43154 1.000 23.22440 ? 269  GLU A O   1 
ATOM   1972 C CB  . GLU A 1 250 ? 1.40379   15.32433  -18.66242 1.000 24.96748 ? 269  GLU A CB  1 
ATOM   1973 C CG  . GLU A 1 250 ? 0.34703   15.87528  -17.70766 1.000 23.78172 ? 269  GLU A CG  1 
ATOM   1974 C CD  . GLU A 1 250 ? -0.79285  16.56910  -18.43155 1.000 27.04581 ? 269  GLU A CD  1 
ATOM   1975 O OE1 . GLU A 1 250 ? -1.84404  16.80058  -17.81295 1.000 27.47909 ? 269  GLU A OE1 1 
ATOM   1976 O OE2 . GLU A 1 250 ? -0.63472  16.88848  -19.63287 1.000 33.42472 ? 269  GLU A OE2 1 
ATOM   1977 N N   . TYR A 1 251 ? 3.57925   16.08461  -16.28370 1.000 17.54151 ? 270  TYR A N   1 
ATOM   1978 C CA  . TYR A 1 251 ? 4.34100   17.23680  -15.84872 1.000 13.05246 ? 270  TYR A CA  1 
ATOM   1979 C C   . TYR A 1 251 ? 5.54136   16.85877  -14.98878 1.000 16.94459 ? 270  TYR A C   1 
ATOM   1980 O O   . TYR A 1 251 ? 6.19461   17.75188  -14.42478 1.000 17.98383 ? 270  TYR A O   1 
ATOM   1981 C CB  . TYR A 1 251 ? 3.44059   18.19026  -15.05686 1.000 18.92701 ? 270  TYR A CB  1 
ATOM   1982 C CG  . TYR A 1 251 ? 2.34881   18.84737  -15.87308 1.000 15.85735 ? 270  TYR A CG  1 
ATOM   1983 C CD1 . TYR A 1 251 ? 2.58624   19.30822  -17.16090 1.000 19.93845 ? 270  TYR A CD1 1 
ATOM   1984 C CD2 . TYR A 1 251 ? 1.07401   19.00155  -15.34303 1.000 20.69058 ? 270  TYR A CD2 1 
ATOM   1985 C CE1 . TYR A 1 251 ? 1.57944   19.91697  -17.90239 1.000 21.59655 ? 270  TYR A CE1 1 
ATOM   1986 C CE2 . TYR A 1 251 ? 0.05453   19.59270  -16.07511 1.000 17.22465 ? 270  TYR A CE2 1 
ATOM   1987 C CZ  . TYR A 1 251 ? 0.30853   20.05070  -17.34543 1.000 20.10658 ? 270  TYR A CZ  1 
ATOM   1988 O OH  . TYR A 1 251 ? -0.71216  20.64618  -18.06653 1.000 20.81130 ? 270  TYR A OH  1 
ATOM   1989 N N   . VAL A 1 252 ? 5.82636   15.56903  -14.83891 1.000 18.78680 ? 271  VAL A N   1 
ATOM   1990 C CA  . VAL A 1 252 ? 6.94250   15.13079  -14.00432 1.000 16.51808 ? 271  VAL A CA  1 
ATOM   1991 C C   . VAL A 1 252 ? 8.24986   15.44129  -14.71900 1.000 18.68236 ? 271  VAL A C   1 
ATOM   1992 O O   . VAL A 1 252 ? 8.76258   14.63169  -15.50223 1.000 19.09933 ? 271  VAL A O   1 
ATOM   1993 C CB  . VAL A 1 252 ? 6.80327   13.64237  -13.65529 1.000 19.28652 ? 271  VAL A CB  1 
ATOM   1994 C CG1 . VAL A 1 252 ? 7.96278   13.20082  -12.78220 1.000 16.17136 ? 271  VAL A CG1 1 
ATOM   1995 C CG2 . VAL A 1 252 ? 5.46166   13.42061  -12.89609 1.000 18.10222 ? 271  VAL A CG2 1 
ATOM   1996 N N   . LYS A 1 253 ? 8.75721   16.64661  -14.49225 1.000 17.14812 ? 272  LYS A N   1 
ATOM   1997 C CA  . LYS A 1 253 ? 9.95005   17.17693  -15.12938 1.000 20.39022 ? 272  LYS A CA  1 
ATOM   1998 C C   . LYS A 1 253 ? 10.70660  17.96740  -14.07774 1.000 18.21737 ? 272  LYS A C   1 
ATOM   1999 O O   . LYS A 1 253 ? 10.08227  18.65333  -13.26157 1.000 16.09883 ? 272  LYS A O   1 
ATOM   2000 C CB  . LYS A 1 253 ? 9.61520   18.07530  -16.33888 1.000 19.53900 ? 272  LYS A CB  1 
ATOM   2001 C CG  . LYS A 1 253 ? 8.67675   17.44816  -17.35407 1.000 20.33397 ? 272  LYS A CG  1 
ATOM   2002 C CD  . LYS A 1 253 ? 8.16665   18.47179  -18.36813 1.000 25.18519 ? 272  LYS A CD  1 
ATOM   2003 C CE  . LYS A 1 253 ? 7.45242   17.77154  -19.53401 1.000 28.71379 ? 272  LYS A CE  1 
ATOM   2004 N NZ  . LYS A 1 253 ? 7.26651   18.68738  -20.69838 1.000 35.19824 ? 272  LYS A NZ  1 
ATOM   2005 N N   . GLN A 1 254 ? 12.04690  17.86249  -14.09137 1.000 16.70544 ? 273  GLN A N   1 
ATOM   2006 C CA  . GLN A 1 254 ? 12.85075  18.49033  -13.03743 1.000 17.31449 ? 273  GLN A CA  1 
ATOM   2007 C C   . GLN A 1 254 ? 12.57881  19.98264  -12.92584 1.000 15.56086 ? 273  GLN A C   1 
ATOM   2008 O O   . GLN A 1 254 ? 12.59962  20.54628  -11.82039 1.000 16.70722 ? 273  GLN A O   1 
ATOM   2009 C CB  . GLN A 1 254 ? 14.34795  18.28029  -13.28153 1.000 21.03064 ? 273  GLN A CB  1 
ATOM   2010 C CG  . GLN A 1 254 ? 15.16744  18.46770  -12.00108 1.000 16.37962 ? 273  GLN A CG  1 
ATOM   2011 C CD  . GLN A 1 254 ? 14.75455  17.47129  -10.91050 1.000 16.54660 ? 273  GLN A CD  1 
ATOM   2012 O OE1 . GLN A 1 254 ? 14.48361  16.31056  -11.19835 1.000 16.62220 ? 273  GLN A OE1 1 
ATOM   2013 N NE2 . GLN A 1 254 ? 14.71322  17.92651  -9.65885  1.000 17.69175 ? 273  GLN A NE2 1 
ATOM   2014 N N   . LYS A 1 255 ? 12.33889  20.64509  -14.06042 1.000 20.07953 ? 274  LYS A N   1 
ATOM   2015 C CA  . LYS A 1 255 ? 12.09876  22.08147  -14.04426 1.000 22.61028 ? 274  LYS A CA  1 
ATOM   2016 C C   . LYS A 1 255 ? 10.89761  22.45829  -13.19684 1.000 22.92862 ? 274  LYS A C   1 
ATOM   2017 O O   . LYS A 1 255 ? 10.78944  23.61458  -12.78788 1.000 22.35159 ? 274  LYS A O   1 
ATOM   2018 C CB  . LYS A 1 255 ? 11.90411  22.60663  -15.46955 1.000 19.96369 ? 274  LYS A CB  1 
ATOM   2019 C CG  . LYS A 1 255 ? 10.86729  21.85651  -16.27704 1.000 22.54575 ? 274  LYS A CG  1 
ATOM   2020 C CD  . LYS A 1 255 ? 10.92076  22.26253  -17.76022 1.000 29.57492 ? 274  LYS A CD  1 
ATOM   2021 C CE  . LYS A 1 255 ? 9.53439   22.40721  -18.37125 1.000 30.61394 ? 274  LYS A CE  1 
ATOM   2022 N NZ  . LYS A 1 255 ? 9.60522   22.86932  -19.79570 1.000 40.28258 ? 274  LYS A NZ  1 
ATOM   2023 N N   . GLY A 1 256 ? 9.99819   21.51430  -12.91054 1.000 18.00611 ? 275  GLY A N   1 
ATOM   2024 C CA  . GLY A 1 256 ? 8.87088   21.83851  -12.05171 1.000 19.57679 ? 275  GLY A CA  1 
ATOM   2025 C C   . GLY A 1 256 ? 9.24717   22.09218  -10.60334 1.000 20.16315 ? 275  GLY A C   1 
ATOM   2026 O O   . GLY A 1 256 ? 8.56057   22.84912  -9.90535  1.000 16.87619 ? 275  GLY A O   1 
ATOM   2027 N N   . GLU A 1 257 ? 10.32910  21.47027  -10.12319 1.000 14.70193 ? 276  GLU A N   1 
ATOM   2028 C CA  . GLU A 1 257 ? 10.65897  21.56956  -8.70388  1.000 18.74812 ? 276  GLU A CA  1 
ATOM   2029 C C   . GLU A 1 257 ? 10.82375  23.01636  -8.26116  1.000 17.54959 ? 276  GLU A C   1 
ATOM   2030 O O   . GLU A 1 257 ? 10.32952  23.41080  -7.19900  1.000 20.46599 ? 276  GLU A O   1 
ATOM   2031 C CB  . GLU A 1 257 ? 11.92777  20.78072  -8.36997  1.000 19.37347 ? 276  GLU A CB  1 
ATOM   2032 C CG  . GLU A 1 257 ? 12.08513  20.62309  -6.86237  1.000 18.51977 ? 276  GLU A CG  1 
ATOM   2033 C CD  . GLU A 1 257 ? 13.23353  19.72541  -6.44762  1.000 22.57355 ? 276  GLU A CD  1 
ATOM   2034 O OE1 . GLU A 1 257 ? 14.35948  19.85520  -6.97602  1.000 22.52706 ? 276  GLU A OE1 1 
ATOM   2035 O OE2 . GLU A 1 257 ? 12.97909  18.84502  -5.60451  1.000 22.47763 ? 276  GLU A OE2 1 
ATOM   2036 N N   . ARG A 1 258 ? 11.54400  23.81989  -9.04259  1.000 17.17594 ? 277  ARG A N   1 
ATOM   2037 C CA  . ARG A 1 258 ? 11.78899  25.19207  -8.60045  1.000 22.79436 ? 277  ARG A CA  1 
ATOM   2038 C C   . ARG A 1 258 ? 10.48888  25.98621  -8.52429  1.000 21.12564 ? 277  ARG A C   1 
ATOM   2039 O O   . ARG A 1 258 ? 10.32848  26.82643  -7.62870  1.000 21.62082 ? 277  ARG A O   1 
ATOM   2040 C CB  . ARG A 1 258 ? 12.79693  25.88006  -9.53063  1.000 21.34243 ? 277  ARG A CB  1 
ATOM   2041 C CG  . ARG A 1 258 ? 12.85771  27.39282  -9.38772  0.000 24.46971 ? 277  ARG A CG  1 
ATOM   2042 C CD  . ARG A 1 258 ? 13.44951  28.05813  -10.62175 0.000 25.35564 ? 277  ARG A CD  1 
ATOM   2043 N NE  . ARG A 1 258 ? 12.53180  28.06181  -11.75564 0.000 25.41561 ? 277  ARG A NE  1 
ATOM   2044 C CZ  . ARG A 1 258 ? 11.43269  28.80080  -11.83198 0.000 25.57089 ? 277  ARG A CZ  1 
ATOM   2045 N NH1 . ARG A 1 258 ? 11.08596  29.62926  -10.85997 0.000 25.96098 ? 277  ARG A NH1 1 
ATOM   2046 N NH2 . ARG A 1 258 ? 10.66572  28.71238  -12.91478 0.000 26.40484 ? 277  ARG A NH2 1 
ATOM   2047 N N   . LYS A 1 259 ? 9.54427   25.71668  -9.43445  1.000 17.83991 ? 278  LYS A N   1 
ATOM   2048 C CA  . LYS A 1 259 ? 8.23264   26.36435  -9.37536  1.000 21.15445 ? 278  LYS A CA  1 
ATOM   2049 C C   . LYS A 1 259 ? 7.43399   25.89517  -8.16652  1.000 21.05541 ? 278  LYS A C   1 
ATOM   2050 O O   . LYS A 1 259 ? 6.68889   26.67754  -7.55930  1.000 18.38944 ? 278  LYS A O   1 
ATOM   2051 C CB  . LYS A 1 259 ? 7.45985   26.09025  -10.67131 1.000 22.16843 ? 278  LYS A CB  1 
ATOM   2052 C CG  . LYS A 1 259 ? 8.21732   26.52324  -11.91103 1.000 20.48869 ? 278  LYS A CG  1 
ATOM   2053 C CD  . LYS A 1 259 ? 7.53859   26.11611  -13.22588 1.000 23.89406 ? 278  LYS A CD  1 
ATOM   2054 C CE  . LYS A 1 259 ? 6.02683   26.30309  -13.18334 1.000 26.46027 ? 278  LYS A CE  1 
ATOM   2055 N NZ  . LYS A 1 259 ? 5.66868   27.73924  -13.40071 1.000 27.78395 ? 278  LYS A NZ  1 
ATOM   2056 N N   . ILE A 1 260 ? 7.54640   24.61014  -7.82345  1.000 16.88937 ? 279  ILE A N   1 
ATOM   2057 C CA  . ILE A 1 260 ? 6.88686   24.10494  -6.62645  1.000 15.25117 ? 279  ILE A CA  1 
ATOM   2058 C C   . ILE A 1 260 ? 7.46634   24.76344  -5.37998  1.000 20.04369 ? 279  ILE A C   1 
ATOM   2059 O O   . ILE A 1 260 ? 6.72950   25.16995  -4.47281  1.000 17.40911 ? 279  ILE A O   1 
ATOM   2060 C CB  . ILE A 1 260 ? 7.00816   22.56999  -6.54936  1.000 14.29374 ? 279  ILE A CB  1 
ATOM   2061 C CG1 . ILE A 1 260 ? 6.32354   21.91113  -7.74687  1.000 15.44355 ? 279  ILE A CG1 1 
ATOM   2062 C CG2 . ILE A 1 260 ? 6.42236   22.06087  -5.24534  1.000 16.04546 ? 279  ILE A CG2 1 
ATOM   2063 C CD1 . ILE A 1 260 ? 6.58675   20.37761  -7.84437  1.000 15.03304 ? 279  ILE A CD1 1 
ATOM   2064 N N   . PHE A 1 261 ? 8.79545   24.85912  -5.29978  1.000 21.32505 ? 280  PHE A N   1 
ATOM   2065 C CA  . PHE A 1 261 ? 9.40495   25.43335  -4.10179  1.000 20.40455 ? 280  PHE A CA  1 
ATOM   2066 C C   . PHE A 1 261 ? 9.04747   26.91298  -3.93510  1.000 17.71398 ? 280  PHE A C   1 
ATOM   2067 O O   . PHE A 1 261 ? 8.89676   27.38712  -2.80201  1.000 21.21099 ? 280  PHE A O   1 
ATOM   2068 C CB  . PHE A 1 261 ? 10.91915  25.22348  -4.15043  1.000 24.48119 ? 280  PHE A CB  1 
ATOM   2069 C CG  . PHE A 1 261 ? 11.33706  23.83986  -3.74266  1.000 25.69140 ? 280  PHE A CG  1 
ATOM   2070 C CD1 . PHE A 1 261 ? 10.45465  23.02294  -3.04989  1.000 24.63618 ? 280  PHE A CD1 1 
ATOM   2071 C CD2 . PHE A 1 261 ? 12.57953  23.33747  -4.08756  1.000 30.37345 ? 280  PHE A CD2 1 
ATOM   2072 C CE1 . PHE A 1 261 ? 10.81490  21.73919  -2.68145  1.000 31.66696 ? 280  PHE A CE1 1 
ATOM   2073 C CE2 . PHE A 1 261 ? 12.94126  22.05085  -3.72281  1.000 29.11380 ? 280  PHE A CE2 1 
ATOM   2074 C CZ  . PHE A 1 261 ? 12.05664  21.25828  -3.01933  1.000 27.27282 ? 280  PHE A CZ  1 
ATOM   2075 N N   . GLN A 1 262 ? 8.92678   27.65408  -5.03646  1.000 20.07416 ? 281  GLN A N   1 
ATOM   2076 C CA  . GLN A 1 262 ? 8.40551   29.01887  -4.96382  1.000 22.86305 ? 281  GLN A CA  1 
ATOM   2077 C C   . GLN A 1 262 ? 6.99716   29.05416  -4.36222  1.000 23.55748 ? 281  GLN A C   1 
ATOM   2078 O O   . GLN A 1 262 ? 6.70468   29.87254  -3.47793  1.000 20.64513 ? 281  GLN A O   1 
ATOM   2079 C CB  . GLN A 1 262 ? 8.39445   29.64362  -6.35529  1.000 25.04294 ? 281  GLN A CB  1 
ATOM   2080 C CG  . GLN A 1 262 ? 8.21458   31.16341  -6.38316  1.000 26.80412 ? 281  GLN A CG  1 
ATOM   2081 C CD  . GLN A 1 262 ? 9.08098   31.88238  -5.36096  1.000 35.71684 ? 281  GLN A CD  1 
ATOM   2082 O OE1 . GLN A 1 262 ? 8.63774   32.21530  -4.24861  1.000 34.29587 ? 281  GLN A OE1 1 
ATOM   2083 N NE2 . GLN A 1 262 ? 10.34541  32.10174  -5.72702  1.000 35.62668 ? 281  GLN A NE2 1 
ATOM   2084 N N   . ALA A 1 263 ? 6.09638   28.19249  -4.85484  1.000 21.77317 ? 282  ALA A N   1 
ATOM   2085 C CA  . ALA A 1 263 ? 4.74845   28.13636  -4.29031  1.000 22.21676 ? 282  ALA A CA  1 
ATOM   2086 C C   . ALA A 1 263 ? 4.78344   27.73628  -2.81956  1.000 20.54217 ? 282  ALA A C   1 
ATOM   2087 O O   . ALA A 1 263 ? 4.03371   28.27562  -1.99092  1.000 20.89073 ? 282  ALA A O   1 
ATOM   2088 C CB  . ALA A 1 263 ? 3.89258   27.15897  -5.09961  1.000 20.79504 ? 282  ALA A CB  1 
ATOM   2089 N N   . HIS A 1 264 ? 5.64589   26.77957  -2.47789  1.000 17.65505 ? 283  HIS A N   1 
ATOM   2090 C CA  . HIS A 1 264 ? 5.78936   26.33548  -1.09509  1.000 19.54504 ? 283  HIS A CA  1 
ATOM   2091 C C   . HIS A 1 264 ? 6.23373   27.48119  -0.19103  1.000 20.84456 ? 283  HIS A C   1 
ATOM   2092 O O   . HIS A 1 264 ? 5.62973   27.74221  0.86386   1.000 20.34723 ? 283  HIS A O   1 
ATOM   2093 C CB  . HIS A 1 264 ? 6.81104   25.20474  -1.05009  1.000 16.50792 ? 283  HIS A CB  1 
ATOM   2094 C CG  . HIS A 1 264 ? 6.88330   24.50903  0.26624   1.000 17.96369 ? 283  HIS A CG  1 
ATOM   2095 N ND1 . HIS A 1 264 ? 7.90058   23.63706  0.58301   1.000 19.42412 ? 283  HIS A ND1 1 
ATOM   2096 C CD2 . HIS A 1 264 ? 6.07005   24.55113  1.34844   1.000 21.99046 ? 283  HIS A CD2 1 
ATOM   2097 C CE1 . HIS A 1 264 ? 7.71062   23.16646  1.80386   1.000 20.06989 ? 283  HIS A CE1 1 
ATOM   2098 N NE2 . HIS A 1 264 ? 6.60602   23.70549  2.28990   1.000 19.33250 ? 283  HIS A NE2 1 
ATOM   2099 N N   . LYS A 1 265 ? 7.31236   28.15542  -0.59061  1.000 19.69311 ? 284  LYS A N   1 
ATOM   2100 C CA  . LYS A 1 265 ? 7.83931   29.29926  0.14978   1.000 24.98216 ? 284  LYS A CA  1 
ATOM   2101 C C   . LYS A 1 265 ? 6.76491   30.36489  0.36254   1.000 25.78004 ? 284  LYS A C   1 
ATOM   2102 O O   . LYS A 1 265 ? 6.59173   30.87327  1.48154   1.000 22.70519 ? 284  LYS A O   1 
ATOM   2103 C CB  . LYS A 1 265 ? 9.03167   29.86885  -0.62372  1.000 27.79257 ? 284  LYS A CB  1 
ATOM   2104 C CG  . LYS A 1 265 ? 10.38542  29.72524  0.07025   1.000 38.95009 ? 284  LYS A CG  1 
ATOM   2105 C CD  . LYS A 1 265 ? 11.44026  30.68088  -0.51686  1.000 43.84372 ? 284  LYS A CD  1 
ATOM   2106 C CE  . LYS A 1 265 ? 11.64396  31.92105  0.33502   1.000 52.25511 ? 284  LYS A CE  1 
ATOM   2107 N NZ  . LYS A 1 265 ? 12.92715  32.60713  -0.01429  1.000 57.18368 ? 284  LYS A NZ  1 
ATOM   2108 N N   . ASN A 1 266 ? 6.01497   30.69463  -0.69760  1.000 18.82824 ? 285  ASN A N   1 
ATOM   2109 C CA  . ASN A 1 266 ? 4.95068   31.69527  -0.60181  1.000 22.29100 ? 285  ASN A CA  1 
ATOM   2110 C C   . ASN A 1 266 ? 3.86632   31.33269  0.39994   1.000 25.29808 ? 285  ASN A C   1 
ATOM   2111 O O   . ASN A 1 266 ? 3.07640   32.20596  0.77337   1.000 24.32144 ? 285  ASN A O   1 
ATOM   2112 C CB  . ASN A 1 266 ? 4.28792   31.93137  -1.95875  1.000 24.88826 ? 285  ASN A CB  1 
ATOM   2113 C CG  . ASN A 1 266 ? 5.22524   32.54468  -2.96966  1.000 24.49489 ? 285  ASN A CG  1 
ATOM   2114 O OD1 . ASN A 1 266 ? 6.22476   33.16008  -2.60577  1.000 27.89459 ? 285  ASN A OD1 1 
ATOM   2115 N ND2 . ASN A 1 266 ? 4.86283   32.46097  -4.24387  1.000 24.24398 ? 285  ASN A ND2 1 
ATOM   2116 N N   . CYS A 1 267 ? 3.78803   30.07951  0.84061   1.000 21.03210 ? 286  CYS A N   1 
ATOM   2117 C CA  . CYS A 1 267 ? 2.83026   29.76055  1.89064   1.000 24.48291 ? 286  CYS A CA  1 
ATOM   2118 C C   . CYS A 1 267 ? 3.25534   30.30791  3.24164   1.000 26.29134 ? 286  CYS A C   1 
ATOM   2119 O O   . CYS A 1 267 ? 2.41594   30.41593  4.13587   1.000 25.06064 ? 286  CYS A O   1 
ATOM   2120 C CB  . CYS A 1 267 ? 2.62685   28.25487  1.99987   1.000 22.30019 ? 286  CYS A CB  1 
ATOM   2121 S SG  . CYS A 1 267 ? 1.75312   27.53838  0.56254   1.000 19.63764 ? 286  CYS A SG  1 
ATOM   2122 N N   . GLY A 1 268 ? 4.53202   30.64337  3.41372   1.000 24.77984 ? 287  GLY A N   1 
ATOM   2123 C CA  . GLY A 1 268 ? 4.98471   31.13455  4.70266   1.000 25.41661 ? 287  GLY A CA  1 
ATOM   2124 C C   . GLY A 1 268 ? 4.73300   30.12623  5.80024   1.000 27.94126 ? 287  GLY A C   1 
ATOM   2125 O O   . GLY A 1 268 ? 4.97285   28.91837  5.64818   1.000 27.48343 ? 287  GLY A O   1 
ATOM   2126 N N   . GLN A 1 269 ? 4.20363   30.61825  6.91732   1.000 22.41392 ? 288  GLN A N   1 
ATOM   2127 C CA  . GLN A 1 269 ? 3.89884   29.77932  8.06503   1.000 26.76884 ? 288  GLN A CA  1 
ATOM   2128 C C   . GLN A 1 269 ? 2.45440   29.29267  8.05777   1.000 28.77189 ? 288  GLN A C   1 
ATOM   2129 O O   . GLN A 1 269 ? 1.91259   28.95348  9.11793   1.000 24.78771 ? 288  GLN A O   1 
ATOM   2130 C CB  . GLN A 1 269 ? 4.18884   30.54152  9.35909   1.000 30.82733 ? 288  GLN A CB  1 
ATOM   2131 C CG  . GLN A 1 269 ? 5.60085   31.10332  9.42350   1.000 30.36772 ? 288  GLN A CG  1 
ATOM   2132 C CD  . GLN A 1 269 ? 6.66972   30.04656  9.23069   1.000 32.80077 ? 288  GLN A CD  1 
ATOM   2133 O OE1 . GLN A 1 269 ? 6.77927   29.10379  10.01430  1.000 39.29306 ? 288  GLN A OE1 1 
ATOM   2134 N NE2 . GLN A 1 269 ? 7.47587   30.20875  8.17869   1.000 33.20140 ? 288  GLN A NE2 1 
ATOM   2135 N N   . MET A 1 270 ? 1.81897   29.24500  6.89022   1.000 24.55688 ? 289  MET A N   1 
ATOM   2136 C CA  . MET A 1 270 ? 0.41196   28.87201  6.84251   1.000 25.97416 ? 289  MET A CA  1 
ATOM   2137 C C   . MET A 1 270 ? 0.22730   27.44709  7.35423   1.000 24.36042 ? 289  MET A C   1 
ATOM   2138 O O   . MET A 1 270 ? 1.09081   26.58047  7.17858   1.000 24.14855 ? 289  MET A O   1 
ATOM   2139 C CB  . MET A 1 270 ? -0.11674  29.14339  5.41624   1.000 31.99715 ? 289  MET A CB  1 
ATOM   2140 C CG  . MET A 1 270 ? -1.49584  28.66073  4.95139   1.000 28.36134 ? 289  MET A CG  1 
ATOM   2141 S SD  . MET A 1 270 ? -1.51386  28.02504  3.24459   1.000 23.47710 ? 289  MET A SD  1 
ATOM   2142 C CE  . MET A 1 270 ? -1.33322  29.56472  2.35603   1.000 22.90973 ? 289  MET A CE  1 
ATOM   2143 N N   . SER A 1 271 ? -0.84473  27.25662  8.12039   1.000 23.56550 ? 290  SER A N   1 
ATOM   2144 C CA  . SER A 1 271 ? -1.09567  26.01465  8.83327   1.000 24.80457 ? 290  SER A CA  1 
ATOM   2145 C C   . SER A 1 271 ? -1.55396  24.90312  7.88441   1.000 21.32252 ? 290  SER A C   1 
ATOM   2146 O O   . SER A 1 271 ? -2.00669  25.16017  6.77356   1.000 21.49478 ? 290  SER A O   1 
ATOM   2147 C CB  . SER A 1 271 ? -2.13788  26.26041  9.92447   1.000 27.25453 ? 290  SER A CB  1 
ATOM   2148 O OG  . SER A 1 271 ? -3.45549  26.11805  9.40785   1.000 31.04734 ? 290  SER A OG  1 
ATOM   2149 N N   . GLU A 1 272 ? -1.42198  23.64867  8.34664   1.000 21.40295 ? 291  GLU A N   1 
ATOM   2150 C CA  . GLU A 1 272 ? -1.87750  22.49938  7.56389   1.000 25.29070 ? 291  GLU A CA  1 
ATOM   2151 C C   . GLU A 1 272 ? -3.33491  22.65713  7.14265   1.000 27.90513 ? 291  GLU A C   1 
ATOM   2152 O O   . GLU A 1 272 ? -3.68546  22.44482  5.97407   1.000 20.63864 ? 291  GLU A O   1 
ATOM   2153 C CB  . GLU A 1 272 ? -1.69120  21.19675  8.35625   1.000 22.58976 ? 291  GLU A CB  1 
ATOM   2154 C CG  . GLU A 1 272 ? -2.40305  20.00528  7.71293   1.000 28.59709 ? 291  GLU A CG  1 
ATOM   2155 C CD  . GLU A 1 272 ? -1.99965  18.64207  8.26792   1.000 36.39791 ? 291  GLU A CD  1 
ATOM   2156 O OE1 . GLU A 1 272 ? -0.97836  18.54214  8.97917   1.000 40.92489 ? 291  GLU A OE1 1 
ATOM   2157 O OE2 . GLU A 1 272 ? -2.71676  17.65445  7.98645   1.000 45.53127 ? 291  GLU A OE2 1 
ATOM   2158 N N   . ILE A 1 273 ? -4.20154  23.02641  8.09190   1.000 22.24096 ? 292  ILE A N   1 
ATOM   2159 C CA  . ILE A 1 273 ? -5.62388  23.17206  7.79698   1.000 22.87437 ? 292  ILE A CA  1 
ATOM   2160 C C   . ILE A 1 273 ? -5.84203  24.23734  6.73231   1.000 24.79237 ? 292  ILE A C   1 
ATOM   2161 O O   . ILE A 1 273 ? -6.64914  24.06319  5.80932   1.000 24.44596 ? 292  ILE A O   1 
ATOM   2162 C CB  . ILE A 1 273 ? -6.40311  23.49281  9.09241   1.000 26.24069 ? 292  ILE A CB  1 
ATOM   2163 C CG1 . ILE A 1 273 ? -6.84341  22.20247  9.78633   1.000 33.93751 ? 292  ILE A CG1 1 
ATOM   2164 C CG2 . ILE A 1 273 ? -7.61089  24.37497  8.80222   1.000 31.39405 ? 292  ILE A CG2 1 
ATOM   2165 C CD1 . ILE A 1 273 ? -7.31965  22.41066  11.22192  1.000 33.91301 ? 292  ILE A CD1 1 
ATOM   2166 N N   . GLU A 1 274 ? -5.12550  25.35127  6.83244   1.000 22.90210 ? 293  GLU A N   1 
ATOM   2167 C CA  . GLU A 1 274 ? -5.39195  26.45223  5.92372   1.000 23.17638 ? 293  GLU A CA  1 
ATOM   2168 C C   . GLU A 1 274 ? -4.84879  26.14263  4.52954   1.000 21.53704 ? 293  GLU A C   1 
ATOM   2169 O O   . GLU A 1 274 ? -5.42758  26.56717  3.52290   1.000 19.53219 ? 293  GLU A O   1 
ATOM   2170 C CB  . GLU A 1 274 ? -4.77995  27.73980  6.48416   1.000 26.65342 ? 293  GLU A CB  1 
ATOM   2171 C CG  . GLU A 1 274 ? -4.89904  28.96741  5.58143   1.000 27.60017 ? 293  GLU A CG  1 
ATOM   2172 C CD  . GLU A 1 274 ? -6.33964  29.22055  5.13705   1.000 41.40636 ? 293  GLU A CD  1 
ATOM   2173 O OE1 . GLU A 1 274 ? -6.57660  29.40779  3.92225   1.000 38.89849 ? 293  GLU A OE1 1 
ATOM   2174 O OE2 . GLU A 1 274 ? -7.24365  29.23583  6.01347   1.000 43.55434 ? 293  GLU A OE2 1 
ATOM   2175 N N   . ALA A 1 275 ? -3.76061  25.38058  4.44795   1.000 21.74230 ? 294  ALA A N   1 
ATOM   2176 C CA  . ALA A 1 275 ? -3.28043  24.95951  3.13703   1.000 20.48598 ? 294  ALA A CA  1 
ATOM   2177 C C   . ALA A 1 275 ? -4.27547  24.01454  2.47160   1.000 16.29829 ? 294  ALA A C   1 
ATOM   2178 O O   . ALA A 1 275 ? -4.47372  24.06624  1.25480   1.000 17.88872 ? 294  ALA A O   1 
ATOM   2179 C CB  . ALA A 1 275 ? -1.90739  24.30280  3.26856   1.000 20.65822 ? 294  ALA A CB  1 
ATOM   2180 N N   . LYS A 1 276 ? -4.90327  23.13846  3.24796   1.000 19.26547 ? 295  LYS A N   1 
ATOM   2181 C CA  . LYS A 1 276 ? -5.93239  22.27842  2.67644   1.000 19.48787 ? 295  LYS A CA  1 
ATOM   2182 C C   . LYS A 1 276 ? -7.09264  23.11222  2.14430   1.000 20.88471 ? 295  LYS A C   1 
ATOM   2183 O O   . LYS A 1 276 ? -7.54523  22.92030  1.00637   1.000 16.86224 ? 295  LYS A O   1 
ATOM   2184 C CB  . LYS A 1 276 ? -6.39761  21.26959  3.72347   1.000 19.97772 ? 295  LYS A CB  1 
ATOM   2185 C CG  . LYS A 1 276 ? -5.37620  20.17511  4.01232   1.000 20.89095 ? 295  LYS A CG  1 
ATOM   2186 C CD  . LYS A 1 276 ? -5.91718  19.16570  5.01598   1.000 21.19308 ? 295  LYS A CD  1 
ATOM   2187 C CE  . LYS A 1 276 ? -4.90805  18.05682  5.30515   1.000 23.42852 ? 295  LYS A CE  1 
ATOM   2188 N NZ  . LYS A 1 276 ? -5.27901  17.26523  6.51373   1.000 31.08954 ? 295  LYS A NZ  1 
ATOM   2189 N N   . VAL A 1 277 ? -7.54923  24.09547  2.92786   1.000 19.86233 ? 296  VAL A N   1 
ATOM   2190 C CA  . VAL A 1 277 ? -8.60871  24.97883  2.44190   1.000 18.97448 ? 296  VAL A CA  1 
ATOM   2191 C C   . VAL A 1 277 ? -8.21064  25.61682  1.11756   1.000 18.65263 ? 296  VAL A C   1 
ATOM   2192 O O   . VAL A 1 277 ? -8.98851  25.63135  0.15690   1.000 19.91391 ? 296  VAL A O   1 
ATOM   2193 C CB  . VAL A 1 277 ? -8.95014  26.04651  3.49424   1.000 22.54285 ? 296  VAL A CB  1 
ATOM   2194 C CG1 . VAL A 1 277 ? -9.92330  27.05519  2.89940   1.000 26.78962 ? 296  VAL A CG1 1 
ATOM   2195 C CG2 . VAL A 1 277 ? -9.53295  25.38984  4.71608   1.000 20.99874 ? 296  VAL A CG2 1 
ATOM   2196 N N   . ARG A 1 278 ? -6.99683  26.17141  1.04905   1.000 15.97069 ? 297  ARG A N   1 
ATOM   2197 C CA  . ARG A 1 278 ? -6.55394  26.83994  -0.16676  1.000 17.74618 ? 297  ARG A CA  1 
ATOM   2198 C C   . ARG A 1 278 ? -6.43515  25.86727  -1.33454  1.000 17.16873 ? 297  ARG A C   1 
ATOM   2199 O O   . ARG A 1 278 ? -6.75007  26.22070  -2.47296  1.000 17.38306 ? 297  ARG A O   1 
ATOM   2200 C CB  . ARG A 1 278 ? -5.21631  27.54686  0.06850   1.000 21.67978 ? 297  ARG A CB  1 
ATOM   2201 C CG  . ARG A 1 278 ? -5.31891  28.79484  0.98690   1.000 21.32240 ? 297  ARG A CG  1 
ATOM   2202 C CD  . ARG A 1 278 ? -6.03603  29.93733  0.26160   1.000 23.85398 ? 297  ARG A CD  1 
ATOM   2203 N NE  . ARG A 1 278 ? -5.33970  30.35277  -0.95594  1.000 23.11976 ? 297  ARG A NE  1 
ATOM   2204 C CZ  . ARG A 1 278 ? -4.32905  31.21243  -0.98873  1.000 26.57174 ? 297  ARG A CZ  1 
ATOM   2205 N NH1 . ARG A 1 278 ? -3.86957  31.77741  0.11723   1.000 21.79656 ? 297  ARG A NH1 1 
ATOM   2206 N NH2 . ARG A 1 278 ? -3.77048  31.51910  -2.16059  1.000 22.57063 ? 297  ARG A NH2 1 
ATOM   2207 N N   . TYR A 1 279 ? -5.92663  24.66344  -1.08361  1.000 17.00994 ? 298  TYR A N   1 
ATOM   2208 C CA  . TYR A 1 279 ? -5.83944  23.66886  -2.15134  1.000 15.57982 ? 298  TYR A CA  1 
ATOM   2209 C C   . TYR A 1 279 ? -7.21581  23.39701  -2.73919  1.000 14.30326 ? 298  TYR A C   1 
ATOM   2210 O O   . TYR A 1 279 ? -7.40560  23.43242  -3.96146  1.000 16.46956 ? 298  TYR A O   1 
ATOM   2211 C CB  . TYR A 1 279 ? -5.22879  22.37149  -1.61102  1.000 16.10155 ? 298  TYR A CB  1 
ATOM   2212 C CG  . TYR A 1 279 ? -4.78030  21.39298  -2.69112  1.000 15.82892 ? 298  TYR A CG  1 
ATOM   2213 C CD1 . TYR A 1 279 ? -5.70642  20.65414  -3.42817  1.000 18.33092 ? 298  TYR A CD1 1 
ATOM   2214 C CD2 . TYR A 1 279 ? -3.42812  21.19879  -2.96532  1.000 15.76228 ? 298  TYR A CD2 1 
ATOM   2215 C CE1 . TYR A 1 279 ? -5.29419  19.74777  -4.42462  1.000 11.90560 ? 298  TYR A CE1 1 
ATOM   2216 C CE2 . TYR A 1 279 ? -3.01306  20.29475  -3.95336  1.000 16.97443 ? 298  TYR A CE2 1 
ATOM   2217 C CZ  . TYR A 1 279 ? -3.95212  19.57377  -4.66975  1.000 15.84787 ? 298  TYR A CZ  1 
ATOM   2218 O OH  . TYR A 1 279 ? -3.53387  18.70146  -5.66214  1.000 13.82142 ? 298  TYR A OH  1 
ATOM   2219 N N   . VAL A 1 280 ? -8.19008  23.12111  -1.87228  1.000 15.94869 ? 299  VAL A N   1 
ATOM   2220 C CA  . VAL A 1 280 ? -9.54347  22.82448  -2.33405  1.000 19.13448 ? 299  VAL A CA  1 
ATOM   2221 C C   . VAL A 1 280 ? -10.13961 24.02499  -3.05332  1.000 22.00893 ? 299  VAL A C   1 
ATOM   2222 O O   . VAL A 1 280 ? -10.73613 23.88702  -4.13482  1.000 16.48413 ? 299  VAL A O   1 
ATOM   2223 C CB  . VAL A 1 280 ? -10.41315 22.36164  -1.15205  1.000 18.43928 ? 299  VAL A CB  1 
ATOM   2224 C CG1 . VAL A 1 280 ? -11.83510 22.10648  -1.61482  1.000 25.70513 ? 299  VAL A CG1 1 
ATOM   2225 C CG2 . VAL A 1 280 ? -9.84519  21.07661  -0.58126  1.000 17.64339 ? 299  VAL A CG2 1 
ATOM   2226 N N   . LYS A 1 281 ? -9.95824  25.22577  -2.48724  1.000 17.40976 ? 300  LYS A N   1 
ATOM   2227 C CA  . LYS A 1 281 ? -10.48650 26.43413  -3.11707  1.000 20.48305 ? 300  LYS A CA  1 
ATOM   2228 C C   . LYS A 1 281 ? -9.89204  26.64606  -4.50059  1.000 19.80583 ? 300  LYS A C   1 
ATOM   2229 O O   . LYS A 1 281 ? -10.60635 27.01317  -5.44469  1.000 19.91911 ? 300  LYS A O   1 
ATOM   2230 C CB  . LYS A 1 281 ? -10.21490 27.65891  -2.22987  1.000 19.94715 ? 300  LYS A CB  1 
ATOM   2231 C CG  . LYS A 1 281 ? -11.08543 27.76825  -0.97507  1.000 24.86454 ? 300  LYS A CG  1 
ATOM   2232 C CD  . LYS A 1 281 ? -10.77458 29.09542  -0.23616  1.000 24.05902 ? 300  LYS A CD  1 
ATOM   2233 C CE  . LYS A 1 281 ? -11.95103 29.64435  0.56888   1.000 38.64898 ? 300  LYS A CE  1 
ATOM   2234 N NZ  . LYS A 1 281 ? -12.83996 28.55864  1.07168   1.000 46.69441 ? 300  LYS A NZ  1 
ATOM   2235 N N   . LEU A 1 282 ? -8.58272  26.42492  -4.65177  1.000 16.82393 ? 301  LEU A N   1 
ATOM   2236 C CA  . LEU A 1 282 ? -7.97903  26.59891  -5.96606  1.000 16.39488 ? 301  LEU A CA  1 
ATOM   2237 C C   . LEU A 1 282 ? -8.54163  25.59241  -6.96647  1.000 16.80348 ? 301  LEU A C   1 
ATOM   2238 O O   . LEU A 1 282 ? -8.80351  25.93946  -8.12467  1.000 19.48580 ? 301  LEU A O   1 
ATOM   2239 C CB  . LEU A 1 282 ? -6.45359  26.48081  -5.87382  1.000 22.32028 ? 301  LEU A CB  1 
ATOM   2240 C CG  . LEU A 1 282 ? -5.66962  26.71315  -7.17684  1.000 20.87659 ? 301  LEU A CG  1 
ATOM   2241 C CD1 . LEU A 1 282 ? -5.89609  28.10277  -7.78601  1.000 18.20514 ? 301  LEU A CD1 1 
ATOM   2242 C CD2 . LEU A 1 282 ? -4.15494  26.43339  -7.00877  1.000 19.59956 ? 301  LEU A CD2 1 
ATOM   2243 N N   . ALA A 1 283 ? -8.73603  24.34229  -6.54194  1.000 16.85175 ? 302  ALA A N   1 
ATOM   2244 C CA  . ALA A 1 283 ? -9.27008  23.34466  -7.46720  1.000 18.70700 ? 302  ALA A CA  1 
ATOM   2245 C C   . ALA A 1 283 ? -10.69757 23.69380  -7.87753  1.000 17.74649 ? 302  ALA A C   1 
ATOM   2246 O O   . ALA A 1 283 ? -11.05059 23.61940  -9.06222  1.000 17.84815 ? 302  ALA A O   1 
ATOM   2247 C CB  . ALA A 1 283 ? -9.20909  21.95018  -6.84231  1.000 17.02195 ? 302  ALA A CB  1 
ATOM   2248 N N   . ARG A 1 284 ? -11.52216 24.11378  -6.91657  1.000 19.96534 ? 303  ARG A N   1 
ATOM   2249 C CA  . ARG A 1 284 ? -12.91873 24.42468  -7.20449  1.000 21.32424 ? 303  ARG A CA  1 
ATOM   2250 C C   . ARG A 1 284 ? -13.07143 25.67493  -8.05226  1.000 24.41593 ? 303  ARG A C   1 
ATOM   2251 O O   . ARG A 1 284 ? -14.13314 25.88126  -8.64959  1.000 22.17456 ? 303  ARG A O   1 
ATOM   2252 C CB  . ARG A 1 284 ? -13.67469 24.57985  -5.88878  1.000 20.72787 ? 303  ARG A CB  1 
ATOM   2253 C CG  . ARG A 1 284 ? -13.77142 23.29193  -5.09580  1.000 22.93004 ? 303  ARG A CG  1 
ATOM   2254 C CD  . ARG A 1 284 ? -14.62147 23.48112  -3.85699  1.000 31.59727 ? 303  ARG A CD  1 
ATOM   2255 N NE  . ARG A 1 284 ? -15.98233 23.85745  -4.20525  1.000 42.55581 ? 303  ARG A NE  1 
ATOM   2256 C CZ  . ARG A 1 284 ? -16.96133 24.01446  -3.32694  1.000 48.05742 ? 303  ARG A CZ  1 
ATOM   2257 N NH1 . ARG A 1 284 ? -16.76399 23.81805  -2.03131  1.000 46.37369 ? 303  ARG A NH1 1 
ATOM   2258 N NH2 . ARG A 1 284 ? -18.16791 24.37547  -3.75915  1.000 47.96036 ? 303  ARG A NH2 1 
ATOM   2259 N N   . SER A 1 285 ? -12.03180 26.50736  -8.11886  1.000 18.35663 ? 304  SER A N   1 
ATOM   2260 C CA  . SER A 1 285 ? -12.06041 27.74223  -8.88715  1.000 21.63063 ? 304  SER A CA  1 
ATOM   2261 C C   . SER A 1 285 ? -11.88356 27.51267  -10.38771 1.000 24.67586 ? 304  SER A C   1 
ATOM   2262 O O   . SER A 1 285 ? -12.18557 28.40809  -11.17906 1.000 21.28515 ? 304  SER A O   1 
ATOM   2263 C CB  . SER A 1 285 ? -10.96854 28.68515  -8.35784  1.000 21.43518 ? 304  SER A CB  1 
ATOM   2264 O OG  . SER A 1 285 ? -9.69808  28.37473  -8.91670  1.000 21.98662 ? 304  SER A OG  1 
ATOM   2265 N N   . LEU A 1 286 ? -11.40314 26.34303  -10.80034 1.000 18.92513 ? 305  LEU A N   1 
ATOM   2266 C CA  . LEU A 1 286 ? -11.12709 26.08651  -12.20517 1.000 20.44219 ? 305  LEU A CA  1 
ATOM   2267 C C   . LEU A 1 286 ? -12.39078 25.63275  -12.93315 1.000 20.23170 ? 305  LEU A C   1 
ATOM   2268 O O   . LEU A 1 286 ? -13.22855 24.91961  -12.37128 1.000 20.51159 ? 305  LEU A O   1 
ATOM   2269 C CB  . LEU A 1 286 ? -10.01314 25.04262  -12.35446 1.000 21.43827 ? 305  LEU A CB  1 
ATOM   2270 C CG  . LEU A 1 286 ? -8.73394  25.31359  -11.55237 1.000 21.89023 ? 305  LEU A CG  1 
ATOM   2271 C CD1 . LEU A 1 286 ? -7.71130  24.18993  -11.73513 1.000 18.82942 ? 305  LEU A CD1 1 
ATOM   2272 C CD2 . LEU A 1 286 ? -8.12844  26.67322  -11.93908 1.000 25.41307 ? 305  LEU A CD2 1 
ATOM   2273 N N   . LYS A 1 287 ? -12.53063 26.07012  -14.18850 1.000 22.27738 ? 306  LYS A N   1 
ATOM   2274 C CA  . LYS A 1 287 ? -13.66085 25.64345  -15.01081 1.000 20.66990 ? 306  LYS A CA  1 
ATOM   2275 C C   . LYS A 1 287 ? -13.64594 24.14656  -15.27809 1.000 23.33438 ? 306  LYS A C   1 
ATOM   2276 O O   . LYS A 1 287 ? -14.67874 23.57577  -15.64829 1.000 23.75381 ? 306  LYS A O   1 
ATOM   2277 C CB  . LYS A 1 287 ? -13.65483 26.37997  -16.35116 1.000 27.90764 ? 306  LYS A CB  1 
ATOM   2278 C CG  . LYS A 1 287 ? -13.86578 27.88373  -16.27219 1.000 33.31224 ? 306  LYS A CG  1 
ATOM   2279 C CD  . LYS A 1 287 ? -14.09546 28.44921  -17.68554 1.000 44.65330 ? 306  LYS A CD  1 
ATOM   2280 C CE  . LYS A 1 287 ? -13.45082 29.82174  -17.88244 1.000 52.16462 ? 306  LYS A CE  1 
ATOM   2281 N NZ  . LYS A 1 287 ? -13.09037 30.09169  -19.32070 1.000 43.34275 ? 306  LYS A NZ  1 
ATOM   2282 N N   . THR A 1 288 ? -12.49198 23.50969  -15.12675 1.000 20.24960 ? 307  THR A N   1 
ATOM   2283 C CA  . THR A 1 288 ? -12.35325 22.07295  -15.29394 1.000 19.57365 ? 307  THR A CA  1 
ATOM   2284 C C   . THR A 1 288 ? -12.81201 21.28182  -14.07465 1.000 18.37400 ? 307  THR A C   1 
ATOM   2285 O O   . THR A 1 288 ? -12.87510 20.04672  -14.14153 1.000 16.20642 ? 307  THR A O   1 
ATOM   2286 C CB  . THR A 1 288 ? -10.89065 21.75442  -15.57247 1.000 18.82079 ? 307  THR A CB  1 
ATOM   2287 O OG1 . THR A 1 288 ? -10.08221 22.43544  -14.59483 1.000 16.45280 ? 307  THR A OG1 1 
ATOM   2288 C CG2 . THR A 1 288 ? -10.49992 22.23584  -16.94973 1.000 15.82526 ? 307  THR A CG2 1 
ATOM   2289 N N   . TYR A 1 289 ? -13.08116 21.94389  -12.95000 1.000 16.61748 ? 308  TYR A N   1 
ATOM   2290 C CA  . TYR A 1 289 ? -13.39426 21.21244  -11.73216 1.000 17.42591 ? 308  TYR A CA  1 
ATOM   2291 C C   . TYR A 1 289 ? -14.70415 20.44821  -11.86348 1.000 16.23768 ? 308  TYR A C   1 
ATOM   2292 O O   . TYR A 1 289 ? -15.72054 21.00934  -12.28482 1.000 19.08038 ? 308  TYR A O   1 
ATOM   2293 C CB  . TYR A 1 289 ? -13.48454 22.16436  -10.54686 1.000 20.07930 ? 308  TYR A CB  1 
ATOM   2294 C CG  . TYR A 1 289 ? -13.82480 21.44566  -9.27009  1.000 18.29982 ? 308  TYR A CG  1 
ATOM   2295 C CD1 . TYR A 1 289 ? -12.86663 20.68941  -8.61192  1.000 20.84126 ? 308  TYR A CD1 1 
ATOM   2296 C CD2 . TYR A 1 289 ? -15.09591 21.52875  -8.71469  1.000 22.57318 ? 308  TYR A CD2 1 
ATOM   2297 C CE1 . TYR A 1 289 ? -13.16227 20.03924  -7.43109  1.000 24.75917 ? 308  TYR A CE1 1 
ATOM   2298 C CE2 . TYR A 1 289 ? -15.39797 20.87330  -7.52351  1.000 23.52204 ? 308  TYR A CE2 1 
ATOM   2299 C CZ  . TYR A 1 289 ? -14.42729 20.14216  -6.89189  1.000 24.70719 ? 308  TYR A CZ  1 
ATOM   2300 O OH  . TYR A 1 289 ? -14.72117 19.48311  -5.71727  1.000 31.47656 ? 308  TYR A OH  1 
ATOM   2301 N N   . GLY A 1 290 ? -14.68714 19.18156  -11.45592 1.000 16.53329 ? 309  GLY A N   1 
ATOM   2302 C CA  . GLY A 1 290 ? -15.86566 18.34088  -11.47719 1.000 19.17478 ? 309  GLY A CA  1 
ATOM   2303 C C   . GLY A 1 290 ? -16.22551 17.77656  -12.83203 1.000 21.32446 ? 309  GLY A C   1 
ATOM   2304 O O   . GLY A 1 290 ? -17.15816 16.96911  -12.92062 1.000 21.41406 ? 309  GLY A O   1 
ATOM   2305 N N   . VAL A 1 291 ? -15.49809 18.13592  -13.86775 1.000 14.41735 ? 310  VAL A N   1 
ATOM   2306 C CA  . VAL A 1 291 ? -15.82654 17.74743  -15.23556 1.000 18.00520 ? 310  VAL A CA  1 
ATOM   2307 C C   . VAL A 1 291 ? -15.26249 16.36447  -15.53747 1.000 17.24066 ? 310  VAL A C   1 
ATOM   2308 O O   . VAL A 1 291 ? -14.12422 16.05678  -15.17204 1.000 19.13509 ? 310  VAL A O   1 
ATOM   2309 C CB  . VAL A 1 291 ? -15.25819 18.80024  -16.20088 1.000 18.66627 ? 310  VAL A CB  1 
ATOM   2310 C CG1 . VAL A 1 291 ? -15.59073 18.46752  -17.65040 1.000 15.12154 ? 310  VAL A CG1 1 
ATOM   2311 C CG2 . VAL A 1 291 ? -15.74837 20.19088  -15.82144 1.000 19.46152 ? 310  VAL A CG2 1 
ATOM   2312 N N   . SER A 1 292 ? -16.04504 15.52638  -16.22018 1.000 16.90285 ? 311  SER A N   1 
ATOM   2313 C CA  . SER A 1 292 ? -15.57038 14.21883  -16.67077 1.000 19.00445 ? 311  SER A CA  1 
ATOM   2314 C C   . SER A 1 292 ? -14.92109 14.37805  -18.04188 1.000 16.58439 ? 311  SER A C   1 
ATOM   2315 O O   . SER A 1 292 ? -15.59404 14.75232  -19.01280 1.000 15.65032 ? 311  SER A O   1 
ATOM   2316 C CB  . SER A 1 292 ? -16.70645 13.19430  -16.75302 1.000 16.42504 ? 311  SER A CB  1 
ATOM   2317 O OG  . SER A 1 292 ? -17.47878 13.13750  -15.55970 1.000 20.04642 ? 311  SER A OG  1 
ATOM   2318 N N   . PHE A 1 293 ? -13.63828 14.02520  -18.14020 1.000 18.88391 ? 312  PHE A N   1 
ATOM   2319 C CA  . PHE A 1 293 ? -12.86772 14.28066  -19.34930 1.000 12.70723 ? 312  PHE A CA  1 
ATOM   2320 C C   . PHE A 1 293 ? -12.50959 13.00336  -20.09917 1.000 15.75269 ? 312  PHE A C   1 
ATOM   2321 O O   . PHE A 1 293 ? -12.31678 11.93207  -19.51212 1.000 16.75086 ? 312  PHE A O   1 
ATOM   2322 C CB  . PHE A 1 293 ? -11.58759 15.05677  -19.01483 1.000 14.30544 ? 312  PHE A CB  1 
ATOM   2323 C CG  . PHE A 1 293 ? -11.81986 16.53434  -18.86934 1.000 13.68209 ? 312  PHE A CG  1 
ATOM   2324 C CD1 . PHE A 1 293 ? -12.01974 17.33514  -19.98152 1.000 14.08153 ? 312  PHE A CD1 1 
ATOM   2325 C CD2 . PHE A 1 293 ? -11.83289 17.11950  -17.60705 1.000 13.09030 ? 312  PHE A CD2 1 
ATOM   2326 C CE1 . PHE A 1 293 ? -12.24553 18.70356  -19.84996 1.000 15.21550 ? 312  PHE A CE1 1 
ATOM   2327 C CE2 . PHE A 1 293 ? -12.03856 18.48564  -17.46147 1.000 16.19457 ? 312  PHE A CE2 1 
ATOM   2328 C CZ  . PHE A 1 293 ? -12.26336 19.27966  -18.58367 1.000 14.67422 ? 312  PHE A CZ  1 
ATOM   2329 N N   . PHE A 1 294 ? -12.40205 13.15515  -21.42157 1.000 15.64907 ? 313  PHE A N   1 
ATOM   2330 C CA  . PHE A 1 294 ? -12.06166 12.09980  -22.36273 1.000 16.21593 ? 313  PHE A CA  1 
ATOM   2331 C C   . PHE A 1 294 ? -11.09529 12.67736  -23.38843 1.000 18.80467 ? 313  PHE A C   1 
ATOM   2332 O O   . PHE A 1 294 ? -11.33061 13.77122  -23.91471 1.000 15.86648 ? 313  PHE A O   1 
ATOM   2333 C CB  . PHE A 1 294 ? -13.32649 11.55793  -23.05608 1.000 16.44496 ? 313  PHE A CB  1 
ATOM   2334 C CG  . PHE A 1 294 ? -14.36464 11.03857  -22.08825 1.000 14.60722 ? 313  PHE A CG  1 
ATOM   2335 C CD1 . PHE A 1 294 ? -15.29030 11.90298  -21.52336 1.000 15.10698 ? 313  PHE A CD1 1 
ATOM   2336 C CD2 . PHE A 1 294 ? -14.38041 9.70240   -21.71698 1.000 17.66410 ? 313  PHE A CD2 1 
ATOM   2337 C CE1 . PHE A 1 294 ? -16.23782 11.43710  -20.62238 1.000 15.44247 ? 313  PHE A CE1 1 
ATOM   2338 C CE2 . PHE A 1 294 ? -15.32611 9.21880   -20.81595 1.000 18.34808 ? 313  PHE A CE2 1 
ATOM   2339 C CZ  . PHE A 1 294 ? -16.25686 10.08630  -20.27098 1.000 17.69002 ? 313  PHE A CZ  1 
ATOM   2340 N N   . LEU A 1 295 ? -10.00580 11.96026  -23.65343 1.000 15.89684 ? 314  LEU A N   1 
ATOM   2341 C CA  . LEU A 1 295 ? -9.06740  12.36417  -24.69268 1.000 18.06045 ? 314  LEU A CA  1 
ATOM   2342 C C   . LEU A 1 295 ? -9.58303  11.85302  -26.03133 1.000 18.45699 ? 314  LEU A C   1 
ATOM   2343 O O   . LEU A 1 295 ? -9.71547  10.63968  -26.21813 1.000 16.07033 ? 314  LEU A O   1 
ATOM   2344 C CB  . LEU A 1 295 ? -7.68093  11.79299  -24.41187 1.000 23.74207 ? 314  LEU A CB  1 
ATOM   2345 C CG  . LEU A 1 295 ? -6.54292  12.28634  -25.31503 1.000 22.94776 ? 314  LEU A CG  1 
ATOM   2346 C CD1 . LEU A 1 295 ? -6.35422  13.81589  -25.28495 1.000 24.07401 ? 314  LEU A CD1 1 
ATOM   2347 C CD2 . LEU A 1 295 ? -5.23762  11.53298  -24.99919 1.000 25.23752 ? 314  LEU A CD2 1 
ATOM   2348 N N   . VAL A 1 296 ? -9.89152  12.76455  -26.94996 1.000 15.63298 ? 315  VAL A N   1 
ATOM   2349 C CA  . VAL A 1 296 ? -10.48296 12.39562  -28.23148 1.000 18.17281 ? 315  VAL A CA  1 
ATOM   2350 C C   . VAL A 1 296 ? -9.60014  12.97373  -29.34223 1.000 21.32895 ? 315  VAL A C   1 
ATOM   2351 O O   . VAL A 1 296 ? -8.74393  13.82101  -29.10234 1.000 20.66361 ? 315  VAL A O   1 
ATOM   2352 C CB  . VAL A 1 296 ? -11.94694 12.88310  -28.35863 1.000 14.96686 ? 315  VAL A CB  1 
ATOM   2353 C CG1 . VAL A 1 296 ? -12.78507 12.36505  -27.18317 1.000 13.61870 ? 315  VAL A CG1 1 
ATOM   2354 C CG2 . VAL A 1 296 ? -12.00817 14.40791  -28.42894 1.000 16.26232 ? 315  VAL A CG2 1 
ATOM   2355 N N   . LYS A 1 297 ? -9.81471  12.50610  -30.56891 1.000 19.77818 ? 316  LYS A N   1 
ATOM   2356 C CA  . LYS A 1 297 ? -8.98214  12.91461  -31.69750 1.000 21.79808 ? 316  LYS A CA  1 
ATOM   2357 C C   . LYS A 1 297 ? -9.81929  13.74084  -32.66626 1.000 18.87587 ? 316  LYS A C   1 
ATOM   2358 O O   . LYS A 1 297 ? -10.79756 13.23963  -33.23145 1.000 19.04440 ? 316  LYS A O   1 
ATOM   2359 C CB  . LYS A 1 297 ? -8.37482  11.69220  -32.38335 1.000 25.27288 ? 316  LYS A CB  1 
ATOM   2360 C CG  . LYS A 1 297 ? -7.32997  10.98150  -31.52339 1.000 28.41136 ? 316  LYS A CG  1 
ATOM   2361 C CD  . LYS A 1 297 ? -6.48892  10.01967  -32.35624 1.000 37.22418 ? 316  LYS A CD  1 
ATOM   2362 C CE  . LYS A 1 297 ? -5.23372  9.56106   -31.61561 1.000 39.73653 ? 316  LYS A CE  1 
ATOM   2363 N NZ  . LYS A 1 297 ? -4.41377  10.70990  -31.14971 1.000 45.87511 ? 316  LYS A NZ  1 
ATOM   2364 N N   . GLU A 1 298 ? -9.43880  15.00957  -32.83959 1.000 21.10248 ? 317  GLU A N   1 
ATOM   2365 C CA  . GLU A 1 298 ? -10.18372 15.95705  -33.65358 1.000 21.73753 ? 317  GLU A CA  1 
ATOM   2366 C C   . GLU A 1 298 ? -9.56241  16.08219  -35.03543 1.000 23.30135 ? 317  GLU A C   1 
ATOM   2367 O O   . GLU A 1 298 ? -8.34484  15.96884  -35.20146 1.000 24.99014 ? 317  GLU A O   1 
ATOM   2368 C CB  . GLU A 1 298 ? -10.22706 17.33753  -32.98826 1.000 19.31894 ? 317  GLU A CB  1 
ATOM   2369 C CG  . GLU A 1 298 ? -11.15332 17.38227  -31.76869 1.000 20.61408 ? 317  GLU A CG  1 
ATOM   2370 C CD  . GLU A 1 298 ? -11.22720 18.75499  -31.13136 1.000 22.49351 ? 317  GLU A CD  1 
ATOM   2371 O OE1 . GLU A 1 298 ? -10.43388 19.63214  -31.51619 1.000 23.20418 ? 317  GLU A OE1 1 
ATOM   2372 O OE2 . GLU A 1 298 ? -12.11535 18.96890  -30.28400 1.000 22.26115 ? 317  GLU A OE2 1 
ATOM   2373 N N   . LYS A 1 299 ? -10.42597 16.29689  -36.03117 1.000 23.17212 ? 318  LYS A N   1 
ATOM   2374 C CA  . LYS A 1 299 ? -10.01127 16.63288  -37.39244 1.000 26.39079 ? 318  LYS A CA  1 
ATOM   2375 C C   . LYS A 1 299 ? -10.04141 18.15473  -37.52002 1.000 25.82013 ? 318  LYS A C   1 
ATOM   2376 O O   . LYS A 1 299 ? -11.10175 18.77316  -37.38751 1.000 31.76359 ? 318  LYS A O   1 
ATOM   2377 C CB  . LYS A 1 299 ? -10.93359 15.94915  -38.40241 1.000 26.03032 ? 318  LYS A CB  1 
ATOM   2378 C CG  . LYS A 1 299 ? -10.69191 16.26217  -39.88839 1.000 35.37889 ? 318  LYS A CG  1 
ATOM   2379 C CD  . LYS A 1 299 ? -9.22411  16.18339  -40.29539 1.000 36.70547 ? 318  LYS A CD  1 
ATOM   2380 C CE  . LYS A 1 299 ? -9.08369  16.29611  -41.81521 1.000 36.80713 ? 318  LYS A CE  1 
ATOM   2381 N NZ  . LYS A 1 299 ? -8.43188  17.56506  -42.21819 1.000 34.06652 ? 318  LYS A NZ  1 
ATOM   2382 N N   . MET A 1 300 ? -8.87575  18.76469  -37.72334 1.000 28.82937 ? 319  MET A N   1 
ATOM   2383 C CA  . MET A 1 300 ? -8.78244  20.20899  -37.92451 1.000 34.97831 ? 319  MET A CA  1 
ATOM   2384 C C   . MET A 1 300 ? -8.85917  20.52965  -39.40877 1.000 37.40620 ? 319  MET A C   1 
ATOM   2385 O O   . MET A 1 300 ? -8.25078  19.84014  -40.23300 1.000 33.30109 ? 319  MET A O   1 
ATOM   2386 C CB  . MET A 1 300 ? -7.47464  20.77300  -37.36071 1.000 32.80749 ? 319  MET A CB  1 
ATOM   2387 C CG  . MET A 1 300 ? -7.35246  20.86903  -35.84419 1.000 39.56624 ? 319  MET A CG  1 
ATOM   2388 S SD  . MET A 1 300 ? -8.89626  20.87824  -34.92753 1.000 40.70684 ? 319  MET A SD  1 
ATOM   2389 C CE  . MET A 1 300 ? -9.13760  22.63692  -34.69912 1.000 41.98092 ? 319  MET A CE  1 
ATOM   2390 N N   . LYS A 1 301 ? -9.60333  21.58363  -39.74297 1.000 37.24352 ? 320  LYS A N   1 
ATOM   2391 C CA  . LYS A 1 301 ? -9.70960  22.00375  -41.13626 1.000 47.87574 ? 320  LYS A CA  1 
ATOM   2392 C C   . LYS A 1 301 ? -8.33548  22.38448  -41.66527 1.000 43.17576 ? 320  LYS A C   1 
ATOM   2393 O O   . LYS A 1 301 ? -7.69099  23.29984  -41.14486 1.000 47.36478 ? 320  LYS A O   1 
ATOM   2394 C CB  . LYS A 1 301 ? -10.67998 23.17831  -41.26982 1.000 50.40850 ? 320  LYS A CB  1 
ATOM   2395 N N   . GLY A 1 302 ? -7.87512  21.65948  -42.68062 1.000 50.59835 ? 321  GLY A N   1 
ATOM   2396 C CA  . GLY A 1 302 ? -6.57863  21.92963  -43.26486 1.000 51.27888 ? 321  GLY A CA  1 
ATOM   2397 C C   . GLY A 1 302 ? -5.40871  21.23143  -42.61342 1.000 53.33568 ? 321  GLY A C   1 
ATOM   2398 O O   . GLY A 1 302 ? -4.28542  21.74522  -42.67111 1.000 59.99989 ? 321  GLY A O   1 
ATOM   2399 N N   . LYS A 1 303 ? -5.62698  20.07563  -41.99056 1.000 47.90717 ? 322  LYS A N   1 
ATOM   2400 C CA  . LYS A 1 303 ? -4.52826  19.30992  -41.41264 1.000 47.70321 ? 322  LYS A CA  1 
ATOM   2401 C C   . LYS A 1 303 ? -4.86141  17.83013  -41.49931 1.000 50.34264 ? 322  LYS A C   1 
ATOM   2402 O O   . LYS A 1 303 ? -5.98602  17.42977  -41.18109 1.000 45.09116 ? 322  LYS A O   1 
ATOM   2403 C CB  . LYS A 1 303 ? -4.26288  19.71601  -39.96088 1.000 48.83453 ? 322  LYS A CB  1 
ATOM   2404 N N   . ASN A 1 304 ? -3.88558  17.02654  -41.93334 1.000 43.83097 ? 323  ASN A N   1 
ATOM   2405 C CA  . ASN A 1 304 ? -4.12283  15.59589  -42.08252 1.000 50.18761 ? 323  ASN A CA  1 
ATOM   2406 C C   . ASN A 1 304 ? -4.00722  14.85867  -40.75496 1.000 49.30575 ? 323  ASN A C   1 
ATOM   2407 O O   . ASN A 1 304 ? -4.78837  13.93853  -40.48822 1.000 48.38933 ? 323  ASN A O   1 
ATOM   2408 C CB  . ASN A 1 304 ? -3.15371  14.99483  -43.10649 1.000 55.06578 ? 323  ASN A CB  1 
ATOM   2409 C CG  . ASN A 1 304 ? -3.20422  15.70094  -44.44798 1.000 59.46289 ? 323  ASN A CG  1 
ATOM   2410 O OD1 . ASN A 1 304 ? -2.16756  15.98096  -45.05641 1.000 65.11555 ? 323  ASN A OD1 1 
ATOM   2411 N ND2 . ASN A 1 304 ? -4.41452  15.98902  -44.91970 1.000 56.92622 ? 323  ASN A ND2 1 
ATOM   2412 N N   . LYS A 1 305 ? -3.03812  15.23121  -39.91988 1.000 39.68157 ? 324  LYS A N   1 
ATOM   2413 C CA  . LYS A 1 305 ? -2.88060  14.57455  -38.62882 1.000 38.46984 ? 324  LYS A CA  1 
ATOM   2414 C C   . LYS A 1 305 ? -3.98532  15.03025  -37.68132 1.000 33.22103 ? 324  LYS A C   1 
ATOM   2415 O O   . LYS A 1 305 ? -4.23207  16.23081  -37.52466 1.000 34.39051 ? 324  LYS A O   1 
ATOM   2416 C CB  . LYS A 1 305 ? -1.50495  14.87331  -38.02664 1.000 34.97657 ? 324  LYS A CB  1 
ATOM   2417 C CG  . LYS A 1 305 ? -1.00144  13.83396  -37.02073 0.000 35.45995 ? 324  LYS A CG  1 
ATOM   2418 C CD  . LYS A 1 305 ? -0.43829  12.57918  -37.67541 0.000 35.58841 ? 324  LYS A CD  1 
ATOM   2419 C CE  . LYS A 1 305 ? 0.80273   12.89973  -38.49631 0.000 35.19261 ? 324  LYS A CE  1 
ATOM   2420 N NZ  . LYS A 1 305 ? 2.02215   12.95673  -37.63981 0.000 34.76103 ? 324  LYS A NZ  1 
ATOM   2421 N N   . LEU A 1 306 ? -4.64325  14.06441  -37.04756 1.000 40.53121 ? 325  LEU A N   1 
ATOM   2422 C CA  . LEU A 1 306 ? -5.68022  14.35922  -36.06961 1.000 26.54675 ? 325  LEU A CA  1 
ATOM   2423 C C   . LEU A 1 306 ? -5.06022  15.02996  -34.84681 1.000 29.47636 ? 325  LEU A C   1 
ATOM   2424 O O   . LEU A 1 306 ? -3.88625  14.82860  -34.53161 1.000 26.83089 ? 325  LEU A O   1 
ATOM   2425 C CB  . LEU A 1 306 ? -6.39303  13.06879  -35.66730 1.000 28.36370 ? 325  LEU A CB  1 
ATOM   2426 C CG  . LEU A 1 306 ? -7.24485  12.47091  -36.79940 1.000 33.31973 ? 325  LEU A CG  1 
ATOM   2427 C CD1 . LEU A 1 306 ? -8.08262  11.30022  -36.31318 1.000 34.78933 ? 325  LEU A CD1 1 
ATOM   2428 C CD2 . LEU A 1 306 ? -8.10497  13.53061  -37.48301 1.000 28.86552 ? 325  LEU A CD2 1 
ATOM   2429 N N   . VAL A 1 307 ? -5.85065  15.84010  -34.15575 1.000 24.98566 ? 326  VAL A N   1 
ATOM   2430 C CA  . VAL A 1 307 ? -5.35801  16.62704  -33.03025 1.000 25.96457 ? 326  VAL A CA  1 
ATOM   2431 C C   . VAL A 1 307 ? -6.00283  16.10300  -31.74822 1.000 26.03843 ? 326  VAL A C   1 
ATOM   2432 O O   . VAL A 1 307 ? -7.23479  16.13461  -31.61909 1.000 19.02130 ? 326  VAL A O   1 
ATOM   2433 C CB  . VAL A 1 307 ? -5.64740  18.12145  -33.22588 1.000 26.04350 ? 326  VAL A CB  1 
ATOM   2434 C CG1 . VAL A 1 307 ? -5.14040  18.90922  -32.04527 1.000 25.75521 ? 326  VAL A CG1 1 
ATOM   2435 C CG2 . VAL A 1 307 ? -4.97310  18.60654  -34.51146 1.000 34.64209 ? 326  VAL A CG2 1 
ATOM   2436 N N   . PRO A 1 308 ? -5.22879  15.61111  -30.78795 1.000 25.37575 ? 327  PRO A N   1 
ATOM   2437 C CA  . PRO A 1 308 ? -5.83254  15.19263  -29.52076 1.000 22.91874 ? 327  PRO A CA  1 
ATOM   2438 C C   . PRO A 1 308 ? -6.39188  16.39375  -28.78249 1.000 24.25462 ? 327  PRO A C   1 
ATOM   2439 O O   . PRO A 1 308 ? -5.78412  17.46639  -28.74672 1.000 22.99055 ? 327  PRO A O   1 
ATOM   2440 C CB  . PRO A 1 308 ? -4.66847  14.54208  -28.75859 1.000 25.30849 ? 327  PRO A CB  1 
ATOM   2441 C CG  . PRO A 1 308 ? -3.62949  14.23169  -29.81392 1.000 31.78196 ? 327  PRO A CG  1 
ATOM   2442 C CD  . PRO A 1 308 ? -3.79287  15.29356  -30.86069 1.000 28.96389 ? 327  PRO A CD  1 
ATOM   2443 N N   . ARG A 1 309 ? -7.57766  16.21309  -28.21018 1.000 20.45776 ? 328  ARG A N   1 
ATOM   2444 C CA  . ARG A 1 309 ? -8.23528  17.28152  -27.47792 1.000 17.23845 ? 328  ARG A CA  1 
ATOM   2445 C C   . ARG A 1 309 ? -8.94546  16.68468  -26.26826 1.000 17.57682 ? 328  ARG A C   1 
ATOM   2446 O O   . ARG A 1 309 ? -9.39797  15.53769  -26.30264 1.000 15.57334 ? 328  ARG A O   1 
ATOM   2447 C CB  . ARG A 1 309 ? -9.22287  18.05115  -28.38468 1.000 17.73830 ? 328  ARG A CB  1 
ATOM   2448 C CG  . ARG A 1 309 ? -9.66658  19.36235  -27.75878 1.000 22.32676 ? 328  ARG A CG  1 
ATOM   2449 C CD  . ARG A 1 309 ? -8.85807  20.55042  -28.27065 1.000 24.82223 ? 328  ARG A CD  1 
ATOM   2450 N NE  . ARG A 1 309 ? -8.62669  20.57207  -29.70975 1.000 21.93585 ? 328  ARG A NE  1 
ATOM   2451 C CZ  . ARG A 1 309 ? -7.74300  21.35942  -30.31344 1.000 29.93067 ? 328  ARG A CZ  1 
ATOM   2452 N NH1 . ARG A 1 309 ? -6.87480  22.08345  -29.62309 1.000 28.55039 ? 328  ARG A NH1 1 
ATOM   2453 N NH2 . ARG A 1 309 ? -7.72494  21.41928  -31.64316 1.000 32.19696 ? 328  ARG A NH2 1 
ATOM   2454 N N   . LEU A 1 310 ? -9.02953  17.46339  -25.19193 1.000 17.52468 ? 329  LEU A N   1 
ATOM   2455 C CA  . LEU A 1 310 ? -9.78078  17.04376  -24.01551 1.000 19.42392 ? 329  LEU A CA  1 
ATOM   2456 C C   . LEU A 1 310 ? -11.24743 17.42468  -24.18681 1.000 19.04449 ? 329  LEU A C   1 
ATOM   2457 O O   . LEU A 1 310 ? -11.58047 18.60564  -24.37793 1.000 19.21309 ? 329  LEU A O   1 
ATOM   2458 C CB  . LEU A 1 310 ? -9.20664  17.65486  -22.73624 1.000 14.82446 ? 329  LEU A CB  1 
ATOM   2459 C CG  . LEU A 1 310 ? -7.87669  17.01864  -22.29064 1.000 16.91832 ? 329  LEU A CG  1 
ATOM   2460 C CD1 . LEU A 1 310 ? -7.14637  17.90996  -21.25421 1.000 17.79426 ? 329  LEU A CD1 1 
ATOM   2461 C CD2 . LEU A 1 310 ? -8.10957  15.60707  -21.74639 1.000 22.79641 ? 329  LEU A CD2 1 
ATOM   2462 N N   . LEU A 1 311 ? -12.12085 16.42746  -24.09040 1.000 13.71107 ? 330  LEU A N   1 
ATOM   2463 C CA  . LEU A 1 311 ? -13.55952 16.61710  -24.19191 1.000 15.83181 ? 330  LEU A CA  1 
ATOM   2464 C C   . LEU A 1 311 ? -14.17175 16.37355  -22.82160 1.000 15.49289 ? 330  LEU A C   1 
ATOM   2465 O O   . LEU A 1 311 ? -14.07112 15.26401  -22.28386 1.000 16.30416 ? 330  LEU A O   1 
ATOM   2466 C CB  . LEU A 1 311 ? -14.15750 15.66755  -25.22623 1.000 17.70540 ? 330  LEU A CB  1 
ATOM   2467 C CG  . LEU A 1 311 ? -15.61802 15.91504  -25.60060 1.000 17.97784 ? 330  LEU A CG  1 
ATOM   2468 C CD1 . LEU A 1 311 ? -15.83476 17.30290  -26.25881 1.000 13.98814 ? 330  LEU A CD1 1 
ATOM   2469 C CD2 . LEU A 1 311 ? -16.14557 14.77049  -26.44631 1.000 14.52647 ? 330  LEU A CD2 1 
ATOM   2470 N N   . GLY A 1 312 ? -14.80927 17.39791  -22.26943 1.000 14.05253 ? 331  GLY A N   1 
ATOM   2471 C CA  . GLY A 1 312 ? -15.37193 17.34491  -20.92590 1.000 15.78251 ? 331  GLY A CA  1 
ATOM   2472 C C   . GLY A 1 312 ? -16.88885 17.40833  -20.95047 1.000 15.26489 ? 331  GLY A C   1 
ATOM   2473 O O   . GLY A 1 312 ? -17.46846 18.15901  -21.72906 1.000 15.21765 ? 331  GLY A O   1 
ATOM   2474 N N   . ILE A 1 313 ? -17.52684 16.60951  -20.09367 1.000 15.66924 ? 332  ILE A N   1 
ATOM   2475 C CA  . ILE A 1 313 ? -18.98386 16.54656  -19.99034 1.000 13.02324 ? 332  ILE A CA  1 
ATOM   2476 C C   . ILE A 1 313 ? -19.37833 16.93482  -18.57257 1.000 16.51145 ? 332  ILE A C   1 
ATOM   2477 O O   . ILE A 1 313 ? -18.86030 16.36302  -17.61100 1.000 15.16915 ? 332  ILE A O   1 
ATOM   2478 C CB  . ILE A 1 313 ? -19.52516 15.13962  -20.29476 1.000 16.99090 ? 332  ILE A CB  1 
ATOM   2479 C CG1 . ILE A 1 313 ? -18.83542 14.52233  -21.51127 1.000 14.82079 ? 332  ILE A CG1 1 
ATOM   2480 C CG2 . ILE A 1 313 ? -21.05719 15.18405  -20.42462 1.000 15.45673 ? 332  ILE A CG2 1 
ATOM   2481 C CD1 . ILE A 1 313 ? -19.13782 15.24863  -22.80749 1.000 17.56810 ? 332  ILE A CD1 1 
ATOM   2482 N N   . THR A 1 314 ? -20.32302 17.86327  -18.43695 1.000 17.34703 ? 333  THR A N   1 
ATOM   2483 C CA  . THR A 1 314 ? -20.89653 18.18836  -17.13158 1.000 21.90951 ? 333  THR A CA  1 
ATOM   2484 C C   . THR A 1 314 ? -22.41342 18.22757  -17.19556 1.000 20.87667 ? 333  THR A C   1 
ATOM   2485 O O   . THR A 1 314 ? -23.02746 18.05206  -18.25227 1.000 19.48124 ? 333  THR A O   1 
ATOM   2486 C CB  . THR A 1 314 ? -20.40073 19.53157  -16.60396 1.000 26.58551 ? 333  THR A CB  1 
ATOM   2487 O OG1 . THR A 1 314 ? -21.17665 20.57933  -17.21785 1.000 28.71255 ? 333  THR A OG1 1 
ATOM   2488 C CG2 . THR A 1 314 ? -18.95235 19.70356  -16.87422 1.000 27.70278 ? 333  THR A CG2 1 
ATOM   2489 N N   . LYS A 1 315 ? -23.00843 18.50056  -16.03064 1.000 21.71776 ? 334  LYS A N   1 
ATOM   2490 C CA  . LYS A 1 315 ? -24.45701 18.53900  -15.90081 1.000 23.74366 ? 334  LYS A CA  1 
ATOM   2491 C C   . LYS A 1 315 ? -25.07958 19.58618  -16.80184 1.000 22.77200 ? 334  LYS A C   1 
ATOM   2492 O O   . LYS A 1 315 ? -26.26839 19.48664  -17.10959 1.000 26.22761 ? 334  LYS A O   1 
ATOM   2493 C CB  . LYS A 1 315 ? -24.85108 18.81739  -14.44839 1.000 26.54220 ? 334  LYS A CB  1 
ATOM   2494 N N   . GLU A 1 316 ? -24.31308 20.58357  -17.24133 1.000 18.84718 ? 335  GLU A N   1 
ATOM   2495 C CA  . GLU A 1 316 ? -24.87986 21.63000  -18.07013 1.000 24.18214 ? 335  GLU A CA  1 
ATOM   2496 C C   . GLU A 1 316 ? -24.23496 21.80793  -19.43810 1.000 23.67560 ? 335  GLU A C   1 
ATOM   2497 O O   . GLU A 1 316 ? -24.85576 22.45353  -20.29139 1.000 22.07292 ? 335  GLU A O   1 
ATOM   2498 C CB  . GLU A 1 316 ? -24.84396 22.98431  -17.33777 1.000 32.40328 ? 335  GLU A CB  1 
ATOM   2499 C CG  . GLU A 1 316 ? -25.47193 22.97384  -15.94041 1.000 37.06231 ? 335  GLU A CG  1 
ATOM   2500 C CD  . GLU A 1 316 ? -24.72635 23.85123  -14.94005 1.000 49.89549 ? 335  GLU A CD  1 
ATOM   2501 O OE1 . GLU A 1 316 ? -23.82979 24.61786  -15.36505 1.000 50.13216 ? 335  GLU A OE1 1 
ATOM   2502 O OE2 . GLU A 1 316 ? -25.03003 23.76512  -13.72437 1.000 52.37730 ? 335  GLU A OE2 1 
ATOM   2503 N N   . CYS A 1 317 ? -23.04355 21.25538  -19.69750 1.000 19.52661 ? 336  CYS A N   1 
ATOM   2504 C CA  . CYS A 1 317 ? -22.39048 21.57312  -20.96329 1.000 15.52777 ? 336  CYS A CA  1 
ATOM   2505 C C   . CYS A 1 317 ? -21.41885 20.48093  -21.39679 1.000 16.84754 ? 336  CYS A C   1 
ATOM   2506 O O   . CYS A 1 317 ? -21.08300 19.56425  -20.64075 1.000 16.09335 ? 336  CYS A O   1 
ATOM   2507 C CB  . CYS A 1 317 ? -21.65680 22.90894  -20.88097 1.000 22.25207 ? 336  CYS A CB  1 
ATOM   2508 S SG  . CYS A 1 317 ? -20.02972 22.77950  -20.11504 1.000 30.51469 ? 336  CYS A SG  1 
ATOM   2509 N N   . VAL A 1 318 ? -20.99007 20.59661  -22.65664 1.000 14.00700 ? 337  VAL A N   1 
ATOM   2510 C CA  . VAL A 1 318 ? -19.86415 19.86332  -23.22417 1.000 15.41260 ? 337  VAL A CA  1 
ATOM   2511 C C   . VAL A 1 318 ? -18.78690 20.88663  -23.56478 1.000 17.58300 ? 337  VAL A C   1 
ATOM   2512 O O   . VAL A 1 318 ? -19.09686 21.94450  -24.12362 1.000 18.37640 ? 337  VAL A O   1 
ATOM   2513 C CB  . VAL A 1 318 ? -20.27993 19.08350  -24.49366 1.000 16.00908 ? 337  VAL A CB  1 
ATOM   2514 C CG1 . VAL A 1 318 ? -19.06785 18.46796  -25.16255 1.000 15.99243 ? 337  VAL A CG1 1 
ATOM   2515 C CG2 . VAL A 1 318 ? -21.34275 18.03753  -24.17184 1.000 14.55822 ? 337  VAL A CG2 1 
ATOM   2516 N N   . MET A 1 319 ? -17.52383 20.58457  -23.24128 1.000 14.46649 ? 338  MET A N   1 
ATOM   2517 C CA  . MET A 1 319 ? -16.45849 21.55961  -23.43530 1.000 13.41678 ? 338  MET A CA  1 
ATOM   2518 C C   . MET A 1 319 ? -15.25880 20.93746  -24.13307 1.000 17.88711 ? 338  MET A C   1 
ATOM   2519 O O   . MET A 1 319 ? -14.91336 19.76759  -23.90785 1.000 15.50029 ? 338  MET A O   1 
ATOM   2520 C CB  . MET A 1 319 ? -16.04165 22.19811  -22.09145 1.000 15.25818 ? 338  MET A CB  1 
ATOM   2521 C CG  . MET A 1 319 ? -15.48398 21.24423  -21.06932 1.000 15.68684 ? 338  MET A CG  1 
ATOM   2522 S SD  . MET A 1 319 ? -14.83671 22.15899  -19.63608 1.000 18.62813 ? 338  MET A SD  1 
ATOM   2523 C CE  . MET A 1 319 ? -16.36247 22.57141  -18.80493 1.000 24.33682 ? 338  MET A CE  1 
ATOM   2524 N N   . ARG A 1 320 ? -14.63355 21.73550  -24.99538 1.000 14.10270 ? 339  ARG A N   1 
ATOM   2525 C CA  . ARG A 1 320 ? -13.37833 21.37648  -25.63929 1.000 14.45494 ? 339  ARG A CA  1 
ATOM   2526 C C   . ARG A 1 320 ? -12.25557 22.08817  -24.89796 1.000 18.82512 ? 339  ARG A C   1 
ATOM   2527 O O   . ARG A 1 320 ? -12.32077 23.30379  -24.69681 1.000 18.74840 ? 339  ARG A O   1 
ATOM   2528 C CB  . ARG A 1 320 ? -13.38291 21.78728  -27.11253 1.000 17.54051 ? 339  ARG A CB  1 
ATOM   2529 C CG  . ARG A 1 320 ? -14.33658 20.96617  -27.96658 1.000 17.39645 ? 339  ARG A CG  1 
ATOM   2530 C CD  . ARG A 1 320 ? -14.39744 21.51768  -29.40570 1.000 17.17582 ? 339  ARG A CD  1 
ATOM   2531 N NE  . ARG A 1 320 ? -13.09444 21.46406  -30.05634 1.000 20.76698 ? 339  ARG A NE  1 
ATOM   2532 C CZ  . ARG A 1 320 ? -12.45190 22.51288  -30.55738 1.000 29.13645 ? 339  ARG A CZ  1 
ATOM   2533 N NH1 . ARG A 1 320 ? -12.95119 23.74174  -30.47728 1.000 25.79852 ? 339  ARG A NH1 1 
ATOM   2534 N NH2 . ARG A 1 320 ? -11.28272 22.32525  -31.16069 1.000 26.32770 ? 339  ARG A NH2 1 
ATOM   2535 N N   . VAL A 1 321 ? -11.23738 21.33388  -24.49604 1.000 19.98212 ? 340  VAL A N   1 
ATOM   2536 C CA  . VAL A 1 321 ? -10.15074 21.85071  -23.67351 1.000 21.58747 ? 340  VAL A CA  1 
ATOM   2537 C C   . VAL A 1 321 ? -8.82457  21.49475  -24.33605 1.000 19.82355 ? 340  VAL A C   1 
ATOM   2538 O O   . VAL A 1 321 ? -8.62703  20.36170  -24.78469 1.000 16.12191 ? 340  VAL A O   1 
ATOM   2539 C CB  . VAL A 1 321 ? -10.24969 21.27596  -22.24077 1.000 16.54885 ? 340  VAL A CB  1 
ATOM   2540 C CG1 . VAL A 1 321 ? -8.93607  21.42206  -21.49036 1.000 19.91169 ? 340  VAL A CG1 1 
ATOM   2541 C CG2 . VAL A 1 321 ? -11.41543 21.92734  -21.49815 1.000 14.78286 ? 340  VAL A CG2 1 
ATOM   2542 N N   . ASP A 1 322 ? -7.91487  22.46384  -24.40359 1.000 19.83659 ? 341  ASP A N   1 
ATOM   2543 C CA  . ASP A 1 322 ? -6.61060  22.21274  -24.99930 1.000 19.55004 ? 341  ASP A CA  1 
ATOM   2544 C C   . ASP A 1 322 ? -5.84488  21.16522  -24.20201 1.000 21.01741 ? 341  ASP A C   1 
ATOM   2545 O O   . ASP A 1 322 ? -5.74074  21.26313  -22.97849 1.000 19.12999 ? 341  ASP A O   1 
ATOM   2546 C CB  . ASP A 1 322 ? -5.79521  23.50477  -25.06930 1.000 23.15094 ? 341  ASP A CB  1 
ATOM   2547 C CG  . ASP A 1 322 ? -4.54852  23.33572  -25.90151 1.000 26.86700 ? 341  ASP A CG  1 
ATOM   2548 O OD1 . ASP A 1 322 ? -4.61094  23.55392  -27.12704 1.000 30.91894 ? 341  ASP A OD1 1 
ATOM   2549 O OD2 . ASP A 1 322 ? -3.51286  22.92904  -25.33466 1.000 24.17254 ? 341  ASP A OD2 1 
ATOM   2550 N N   . GLU A 1 323 ? -5.29268  20.17154  -24.91299 1.000 21.52675 ? 342  GLU A N   1 
ATOM   2551 C CA  . GLU A 1 323 ? -4.61686  19.04405  -24.27066 1.000 22.73921 ? 342  GLU A CA  1 
ATOM   2552 C C   . GLU A 1 323 ? -3.38686  19.48324  -23.48590 1.000 28.63695 ? 342  GLU A C   1 
ATOM   2553 O O   . GLU A 1 323 ? -2.98755  18.81306  -22.51975 1.000 22.58239 ? 342  GLU A O   1 
ATOM   2554 C CB  . GLU A 1 323 ? -4.18831  18.00863  -25.31683 1.000 25.06366 ? 342  GLU A CB  1 
ATOM   2555 C CG  . GLU A 1 323 ? -3.49404  16.77524  -24.68499 1.000 28.21553 ? 342  GLU A CG  1 
ATOM   2556 C CD  . GLU A 1 323 ? -3.01432  15.74761  -25.69622 1.000 41.53457 ? 342  GLU A CD  1 
ATOM   2557 O OE1 . GLU A 1 323 ? -2.59129  16.16179  -26.80390 1.000 44.18928 ? 342  GLU A OE1 1 
ATOM   2558 O OE2 . GLU A 1 323 ? -2.99994  14.53541  -25.36885 1.000 41.38316 ? 342  GLU A OE2 1 
ATOM   2559 N N   . LYS A 1 324 ? -2.75382  20.58185  -23.88843 1.000 23.34701 ? 343  LYS A N   1 
ATOM   2560 C CA  . LYS A 1 324 ? -1.50237  20.95640  -23.23727 1.000 29.44097 ? 343  LYS A CA  1 
ATOM   2561 C C   . LYS A 1 324 ? -1.67746  22.09337  -22.23582 1.000 27.02879 ? 343  LYS A C   1 
ATOM   2562 O O   . LYS A 1 324 ? -1.19527  21.98591  -21.10511 1.000 28.52009 ? 343  LYS A O   1 
ATOM   2563 C CB  . LYS A 1 324 ? -0.43916  21.31355  -24.29078 1.000 30.59504 ? 343  LYS A CB  1 
ATOM   2564 C CG  . LYS A 1 324 ? 0.68173   22.18768  -23.74581 1.000 38.43646 ? 343  LYS A CG  1 
ATOM   2565 C CD  . LYS A 1 324 ? 1.68624   22.62983  -24.81614 1.000 37.38748 ? 343  LYS A CD  1 
ATOM   2566 C CE  . LYS A 1 324 ? 3.01361   23.05949  -24.16254 1.000 43.51773 ? 343  LYS A CE  1 
ATOM   2567 N NZ  . LYS A 1 324 ? 4.17855   23.04883  -25.10331 1.000 51.72114 ? 343  LYS A NZ  1 
ATOM   2568 N N   . THR A 1 325 ? -2.38446  23.16432  -22.61194 1.000 24.21537 ? 344  THR A N   1 
ATOM   2569 C CA  . THR A 1 325 ? -2.59547  24.31913  -21.73911 1.000 24.00317 ? 344  THR A CA  1 
ATOM   2570 C C   . THR A 1 325 ? -3.83069  24.20368  -20.85749 1.000 23.27198 ? 344  THR A C   1 
ATOM   2571 O O   . THR A 1 325 ? -3.95981  24.96290  -19.89088 1.000 21.93336 ? 344  THR A O   1 
ATOM   2572 C CB  . THR A 1 325 ? -2.72712  25.60913  -22.56381 1.000 27.02040 ? 344  THR A CB  1 
ATOM   2573 O OG1 . THR A 1 325 ? -3.96940  25.59332  -23.28911 1.000 23.72375 ? 344  THR A OG1 1 
ATOM   2574 C CG2 . THR A 1 325 ? -1.57122  25.75970  -23.52248 1.000 23.77744 ? 344  THR A CG2 1 
ATOM   2575 N N   . LYS A 1 326 ? -4.75451  23.30775  -21.19267 1.000 20.83015 ? 345  LYS A N   1 
ATOM   2576 C CA  . LYS A 1 326 ? -5.99073  23.10105  -20.44289 1.000 18.56061 ? 345  LYS A CA  1 
ATOM   2577 C C   . LYS A 1 326 ? -6.88353  24.34469  -20.47710 1.000 19.80536 ? 345  LYS A C   1 
ATOM   2578 O O   . LYS A 1 326 ? -7.80500  24.49357  -19.66644 1.000 20.31235 ? 345  LYS A O   1 
ATOM   2579 C CB  . LYS A 1 326 ? -5.70011  22.65970  -19.00073 1.000 20.93572 ? 345  LYS A CB  1 
ATOM   2580 C CG  . LYS A 1 326 ? -5.43822  21.14839  -18.87259 1.000 17.74623 ? 345  LYS A CG  1 
ATOM   2581 C CD  . LYS A 1 326 ? -4.21712  20.68820  -19.69718 1.000 19.26737 ? 345  LYS A CD  1 
ATOM   2582 C CE  . LYS A 1 326 ? -3.64083  19.34727  -19.20672 1.000 21.01672 ? 345  LYS A CE  1 
ATOM   2583 N NZ  . LYS A 1 326 ? -2.22918  19.11425  -19.68372 1.000 18.64144 ? 345  LYS A NZ  1 
ATOM   2584 N N   . GLU A 1 327 ? -6.62938  25.24216  -21.42188 1.000 22.73442 ? 346  GLU A N   1 
ATOM   2585 C CA  . GLU A 1 327 ? -7.55457  26.33633  -21.64382 1.000 27.48142 ? 346  GLU A CA  1 
ATOM   2586 C C   . GLU A 1 327 ? -8.84904  25.78694  -22.22986 1.000 23.31718 ? 346  GLU A C   1 
ATOM   2587 O O   . GLU A 1 327 ? -8.83573  24.90439  -23.09742 1.000 20.52249 ? 346  GLU A O   1 
ATOM   2588 C CB  . GLU A 1 327 ? -6.94041  27.38498  -22.57233 1.000 27.87006 ? 346  GLU A CB  1 
ATOM   2589 C CG  . GLU A 1 327 ? -7.97701  28.25627  -23.28504 1.000 35.73317 ? 346  GLU A CG  1 
ATOM   2590 C CD  . GLU A 1 327 ? -7.38317  29.23736  -24.29581 1.000 37.56256 ? 346  GLU A CD  1 
ATOM   2591 O OE1 . GLU A 1 327 ? -7.82574  30.41253  -24.30624 1.000 43.84291 ? 346  GLU A OE1 1 
ATOM   2592 O OE2 . GLU A 1 327 ? -6.47470  28.84631  -25.06222 1.000 39.54269 ? 346  GLU A OE2 1 
ATOM   2593 N N   . VAL A 1 328 ? -9.96825  26.28406  -21.71526 1.000 21.33824 ? 347  VAL A N   1 
ATOM   2594 C CA  . VAL A 1 328 ? -11.27324 25.97625  -22.28960 1.000 19.49344 ? 347  VAL A CA  1 
ATOM   2595 C C   . VAL A 1 328 ? -11.43574 26.72562  -23.60499 1.000 26.72564 ? 347  VAL A C   1 
ATOM   2596 O O   . VAL A 1 328 ? -11.50623 27.96190  -23.62984 1.000 23.53420 ? 347  VAL A O   1 
ATOM   2597 C CB  . VAL A 1 328 ? -12.39212 26.32127  -21.30896 1.000 21.25378 ? 347  VAL A CB  1 
ATOM   2598 C CG1 . VAL A 1 328 ? -13.74521 25.96745  -21.91708 1.000 25.58049 ? 347  VAL A CG1 1 
ATOM   2599 C CG2 . VAL A 1 328 ? -12.17507 25.55310  -20.01306 1.000 26.45551 ? 347  VAL A CG2 1 
ATOM   2600 N N   . ILE A 1 329 ? -11.52547 25.97064  -24.69885 1.000 20.82900 ? 348  ILE A N   1 
ATOM   2601 C CA  . ILE A 1 329 ? -11.53911 26.53871  -26.04348 1.000 27.43447 ? 348  ILE A CA  1 
ATOM   2602 C C   . ILE A 1 329 ? -12.96178 26.78610  -26.55584 1.000 26.13830 ? 348  ILE A C   1 
ATOM   2603 O O   . ILE A 1 329 ? -13.19756 27.75331  -27.29490 1.000 27.01780 ? 348  ILE A O   1 
ATOM   2604 C CB  . ILE A 1 329 ? -10.76601 25.58893  -26.97368 1.000 26.58836 ? 348  ILE A CB  1 
ATOM   2605 C CG1 . ILE A 1 329 ? -9.26284  25.70301  -26.70637 1.000 33.21125 ? 348  ILE A CG1 1 
ATOM   2606 C CG2 . ILE A 1 329 ? -11.04731 25.88976  -28.43589 1.000 34.87629 ? 348  ILE A CG2 1 
ATOM   2607 C CD1 . ILE A 1 329 ? -8.61992  26.92936  -27.31503 1.000 39.54730 ? 348  ILE A CD1 1 
ATOM   2608 N N   . GLN A 1 330 ? -13.91821 25.93970  -26.17641 1.000 23.47570 ? 349  GLN A N   1 
ATOM   2609 C CA  . GLN A 1 330 ? -15.29264 26.01781  -26.66627 1.000 23.74670 ? 349  GLN A CA  1 
ATOM   2610 C C   . GLN A 1 330 ? -16.21463 25.30347  -25.68783 1.000 25.44078 ? 349  GLN A C   1 
ATOM   2611 O O   . GLN A 1 330 ? -15.83437 24.28991  -25.10169 1.000 20.74838 ? 349  GLN A O   1 
ATOM   2612 C CB  . GLN A 1 330 ? -15.41633 25.36342  -28.04118 1.000 20.92889 ? 349  GLN A CB  1 
ATOM   2613 C CG  . GLN A 1 330 ? -16.83061 25.33512  -28.60425 1.000 25.78596 ? 349  GLN A CG  1 
ATOM   2614 C CD  . GLN A 1 330 ? -16.83493 25.10253  -30.09305 1.000 25.44261 ? 349  GLN A CD  1 
ATOM   2615 O OE1 . GLN A 1 330 ? -15.89033 24.52152  -30.64016 1.000 24.07863 ? 349  GLN A OE1 1 
ATOM   2616 N NE2 . GLN A 1 330 ? -17.90800 25.52646  -30.76264 1.000 22.35855 ? 349  GLN A NE2 1 
ATOM   2617 N N   . GLU A 1 331 ? -17.44126 25.81118  -25.54533 1.000 19.34312 ? 350  GLU A N   1 
ATOM   2618 C CA  . GLU A 1 331 ? -18.45194 25.14653  -24.72960 1.000 23.79947 ? 350  GLU A CA  1 
ATOM   2619 C C   . GLU A 1 331 ? -19.78959 25.14993  -25.45235 1.000 25.31427 ? 350  GLU A C   1 
ATOM   2620 O O   . GLU A 1 331 ? -20.17332 26.16292  -26.04625 1.000 25.04041 ? 350  GLU A O   1 
ATOM   2621 C CB  . GLU A 1 331 ? -18.62946 25.82396  -23.36532 1.000 22.44798 ? 350  GLU A CB  1 
ATOM   2622 C CG  . GLU A 1 331 ? -17.38104 25.91245  -22.52269 1.000 29.99890 ? 350  GLU A CG  1 
ATOM   2623 C CD  . GLU A 1 331 ? -17.58059 26.77328  -21.28077 1.000 42.08343 ? 350  GLU A CD  1 
ATOM   2624 O OE1 . GLU A 1 331 ? -17.24286 27.97749  -21.33216 1.000 47.60317 ? 350  GLU A OE1 1 
ATOM   2625 O OE2 . GLU A 1 331 ? -18.07948 26.24963  -20.25984 1.000 45.29740 ? 350  GLU A OE2 1 
ATOM   2626 N N   . TRP A 1 332 ? -20.50119 24.02215  -25.37858 1.000 17.97836 ? 351  TRP A N   1 
ATOM   2627 C CA  . TRP A 1 332 ? -21.86447 23.89335  -25.88352 1.000 20.65916 ? 351  TRP A CA  1 
ATOM   2628 C C   . TRP A 1 332 ? -22.79170 23.57121  -24.72151 1.000 21.89582 ? 351  TRP A C   1 
ATOM   2629 O O   . TRP A 1 332 ? -22.54612 22.61633  -23.98037 1.000 18.77813 ? 351  TRP A O   1 
ATOM   2630 C CB  . TRP A 1 332 ? -21.97383 22.76396  -26.89885 1.000 21.29209 ? 351  TRP A CB  1 
ATOM   2631 C CG  . TRP A 1 332 ? -21.18692 22.91654  -28.15382 1.000 24.27265 ? 351  TRP A CG  1 
ATOM   2632 C CD1 . TRP A 1 332 ? -21.44321 23.75009  -29.21410 1.000 24.20924 ? 351  TRP A CD1 1 
ATOM   2633 C CD2 . TRP A 1 332 ? -19.99115 22.20506  -28.47692 1.000 20.82295 ? 351  TRP A CD2 1 
ATOM   2634 N NE1 . TRP A 1 332 ? -20.47575 23.58112  -30.18849 1.000 21.15838 ? 351  TRP A NE1 1 
ATOM   2635 C CE2 . TRP A 1 332 ? -19.57901 22.63373  -29.75615 1.000 25.51196 ? 351  TRP A CE2 1 
ATOM   2636 C CE3 . TRP A 1 332 ? -19.23058 21.23577  -27.80721 1.000 20.21010 ? 351  TRP A CE3 1 
ATOM   2637 C CZ2 . TRP A 1 332 ? -18.44132 22.12692  -30.37669 1.000 23.94499 ? 351  TRP A CZ2 1 
ATOM   2638 C CZ3 . TRP A 1 332 ? -18.10801 20.73649  -28.42465 1.000 21.92359 ? 351  TRP A CZ3 1 
ATOM   2639 C CH2 . TRP A 1 332 ? -17.72678 21.17924  -29.70275 1.000 22.21872 ? 351  TRP A CH2 1 
ATOM   2640 N N   . SER A 1 333 ? -23.87012 24.33193  -24.57484 1.000 19.75032 ? 352  SER A N   1 
ATOM   2641 C CA  . SER A 1 333 ? -24.86592 23.96649  -23.58187 1.000 19.28492 ? 352  SER A CA  1 
ATOM   2642 C C   . SER A 1 333 ? -25.54268 22.66043  -23.99231 1.000 18.38548 ? 352  SER A C   1 
ATOM   2643 O O   . SER A 1 333 ? -25.75433 22.40670  -25.18430 1.000 17.11827 ? 352  SER A O   1 
ATOM   2644 C CB  . SER A 1 333 ? -25.89726 25.09060  -23.43665 1.000 22.26912 ? 352  SER A CB  1 
ATOM   2645 O OG  . SER A 1 333 ? -27.03597 24.66066  -22.71710 1.000 22.09749 ? 352  SER A OG  1 
ATOM   2646 N N   . LEU A 1 334 ? -25.87683 21.81440  -23.00445 1.000 18.86899 ? 353  LEU A N   1 
ATOM   2647 C CA  . LEU A 1 334 ? -26.59104 20.57583  -23.33060 1.000 17.64224 ? 353  LEU A CA  1 
ATOM   2648 C C   . LEU A 1 334 ? -27.90181 20.86356  -24.05622 1.000 20.62718 ? 353  LEU A C   1 
ATOM   2649 O O   . LEU A 1 334 ? -28.36370 20.04580  -24.86831 1.000 16.88365 ? 353  LEU A O   1 
ATOM   2650 C CB  . LEU A 1 334 ? -26.86209 19.75326  -22.06406 1.000 16.36755 ? 353  LEU A CB  1 
ATOM   2651 C CG  . LEU A 1 334 ? -25.61316 19.19057  -21.36735 1.000 20.18075 ? 353  LEU A CG  1 
ATOM   2652 C CD1 . LEU A 1 334 ? -25.98648 18.23049  -20.22292 1.000 20.36522 ? 353  LEU A CD1 1 
ATOM   2653 C CD2 . LEU A 1 334 ? -24.77433 18.47424  -22.38670 1.000 16.78830 ? 353  LEU A CD2 1 
ATOM   2654 N N   . THR A 1 335 ? -28.51127 22.02047  -23.76798 1.000 17.95824 ? 354  THR A N   1 
ATOM   2655 C CA  . THR A 1 335 ? -29.75653 22.43834  -24.40358 1.000 18.31069 ? 354  THR A CA  1 
ATOM   2656 C C   . THR A 1 335 ? -29.61641 22.60299  -25.90890 1.000 21.43901 ? 354  THR A C   1 
ATOM   2657 O O   . THR A 1 335 ? -30.61363 22.47570  -26.62550 1.000 24.80953 ? 354  THR A O   1 
ATOM   2658 C CB  . THR A 1 335 ? -30.23698 23.75360  -23.76438 1.000 20.74749 ? 354  THR A CB  1 
ATOM   2659 O OG1 . THR A 1 335 ? -30.19539 23.62946  -22.33568 1.000 23.89514 ? 354  THR A OG1 1 
ATOM   2660 C CG2 . THR A 1 335 ? -31.64004 24.15755  -24.23227 1.000 24.52986 ? 354  THR A CG2 1 
ATOM   2661 N N   . ASN A 1 336 ? -28.40691 22.86644  -26.40475 1.000 17.25006 ? 355  ASN A N   1 
ATOM   2662 C CA  . ASN A 1 336 ? -28.19661 23.18054  -27.81184 1.000 18.76326 ? 355  ASN A CA  1 
ATOM   2663 C C   . ASN A 1 336 ? -27.61201 22.00056  -28.58805 1.000 17.64931 ? 355  ASN A C   1 
ATOM   2664 O O   . ASN A 1 336 ? -27.11009 22.17944  -29.70156 1.000 18.32730 ? 355  ASN A O   1 
ATOM   2665 C CB  . ASN A 1 336 ? -27.32927 24.43512  -27.91784 1.000 18.67372 ? 355  ASN A CB  1 
ATOM   2666 C CG  . ASN A 1 336 ? -27.99924 25.64505  -27.25091 1.000 19.40522 ? 355  ASN A CG  1 
ATOM   2667 O OD1 . ASN A 1 336 ? -29.23097 25.67762  -27.10204 1.000 20.85793 ? 355  ASN A OD1 1 
ATOM   2668 N ND2 . ASN A 1 336 ? -27.20506 26.63537  -26.85703 1.000 24.14860 ? 355  ASN A ND2 1 
ATOM   2669 N N   . ILE A 1 337 ? -27.67680 20.79716  -28.01593 1.000 17.10821 ? 356  ILE A N   1 
ATOM   2670 C CA  . ILE A 1 337 ? -27.32323 19.56449  -28.71697 1.000 16.72007 ? 356  ILE A CA  1 
ATOM   2671 C C   . ILE A 1 337 ? -28.60147 18.91421  -29.22428 1.000 17.09708 ? 356  ILE A C   1 
ATOM   2672 O O   . ILE A 1 337 ? -29.52244 18.64987  -28.44328 1.000 17.09081 ? 356  ILE A O   1 
ATOM   2673 C CB  . ILE A 1 337 ? -26.54397 18.60242  -27.80495 1.000 19.41436 ? 356  ILE A CB  1 
ATOM   2674 C CG1 . ILE A 1 337 ? -25.23101 19.23998  -27.32073 1.000 19.50774 ? 356  ILE A CG1 1 
ATOM   2675 C CG2 . ILE A 1 337 ? -26.34756 17.24878  -28.49600 1.000 18.13103 ? 356  ILE A CG2 1 
ATOM   2676 C CD1 . ILE A 1 337 ? -24.53181 18.42626  -26.25124 1.000 25.48880 ? 356  ILE A CD1 1 
ATOM   2677 N N   . LYS A 1 338 ? -28.66876 18.66389  -30.53626 1.000 17.03844 ? 357  LYS A N   1 
ATOM   2678 C CA  . LYS A 1 338 ? -29.87550 18.08162  -31.11829 1.000 18.05752 ? 357  LYS A CA  1 
ATOM   2679 C C   . LYS A 1 338 ? -29.89777 16.56499  -30.96609 1.000 20.59409 ? 357  LYS A C   1 
ATOM   2680 O O   . LYS A 1 338 ? -30.93266 15.98225  -30.62360 1.000 18.45185 ? 357  LYS A O   1 
ATOM   2681 C CB  . LYS A 1 338 ? -29.98100 18.46138  -32.59737 1.000 17.01177 ? 357  LYS A CB  1 
ATOM   2682 C CG  . LYS A 1 338 ? -31.24049 17.95581  -33.26440 1.000 21.24170 ? 357  LYS A CG  1 
ATOM   2683 C CD  . LYS A 1 338 ? -31.40753 18.62605  -34.63186 1.000 25.54371 ? 357  LYS A CD  1 
ATOM   2684 C CE  . LYS A 1 338 ? -32.76589 18.28800  -35.25281 1.000 29.62930 ? 357  LYS A CE  1 
ATOM   2685 N NZ  . LYS A 1 338 ? -32.59563 18.01285  -36.71437 1.000 37.99552 ? 357  LYS A NZ  1 
ATOM   2686 N N   . ARG A 1 339 ? -28.77055 15.91165  -31.22361 1.000 17.82295 ? 358  ARG A N   1 
ATOM   2687 C CA  . ARG A 1 339 ? -28.66520 14.47650  -31.03227 1.000 19.79365 ? 358  ARG A CA  1 
ATOM   2688 C C   . ARG A 1 339 ? -27.18682 14.12280  -30.97669 1.000 17.79854 ? 358  ARG A C   1 
ATOM   2689 O O   . ARG A 1 339 ? -26.31593 14.94305  -31.27855 1.000 14.76511 ? 358  ARG A O   1 
ATOM   2690 C CB  . ARG A 1 339 ? -29.37344 13.69084  -32.14805 1.000 21.85453 ? 358  ARG A CB  1 
ATOM   2691 C CG  . ARG A 1 339 ? -28.80201 13.91099  -33.51995 1.000 21.81556 ? 358  ARG A CG  1 
ATOM   2692 C CD  . ARG A 1 339 ? -29.83190 13.63817  -34.63155 1.000 25.75057 ? 358  ARG A CD  1 
ATOM   2693 N NE  . ARG A 1 339 ? -29.26364 13.91240  -35.94541 1.000 22.67922 ? 358  ARG A NE  1 
ATOM   2694 C CZ  . ARG A 1 339 ? -28.95791 13.01748  -36.87564 1.000 26.44656 ? 358  ARG A CZ  1 
ATOM   2695 N NH1 . ARG A 1 339 ? -29.34924 11.75462  -36.78299 1.000 24.52486 ? 358  ARG A NH1 1 
ATOM   2696 N NH2 . ARG A 1 339 ? -28.28805 13.41457  -37.96010 1.000 23.00445 ? 358  ARG A NH2 1 
ATOM   2697 N N   . TRP A 1 340 ? -26.91650 12.88472  -30.57673 1.000 16.91581 ? 359  TRP A N   1 
ATOM   2698 C CA  . TRP A 1 340 ? -25.55532 12.39287  -30.44750 1.000 16.32320 ? 359  TRP A CA  1 
ATOM   2699 C C   . TRP A 1 340 ? -25.53924 10.94103  -30.90753 1.000 14.64886 ? 359  TRP A C   1 
ATOM   2700 O O   . TRP A 1 340 ? -26.58205 10.28948  -31.00807 1.000 16.50074 ? 359  TRP A O   1 
ATOM   2701 C CB  . TRP A 1 340 ? -25.02959 12.52728  -29.00350 1.000 17.65098 ? 359  TRP A CB  1 
ATOM   2702 C CG  . TRP A 1 340 ? -25.92096 11.86758  -27.97472 1.000 18.55623 ? 359  TRP A CG  1 
ATOM   2703 C CD1 . TRP A 1 340 ? -25.81687 10.59272  -27.50122 1.000 20.37927 ? 359  TRP A CD1 1 
ATOM   2704 C CD2 . TRP A 1 340 ? -27.03700 12.46014  -27.29668 1.000 18.62485 ? 359  TRP A CD2 1 
ATOM   2705 N NE1 . TRP A 1 340 ? -26.81537 10.34564  -26.58595 1.000 25.70636 ? 359  TRP A NE1 1 
ATOM   2706 C CE2 . TRP A 1 340 ? -27.56796 11.48323  -26.43173 1.000 26.44624 ? 359  TRP A CE2 1 
ATOM   2707 C CE3 . TRP A 1 340 ? -27.63506 13.72464  -27.33489 1.000 24.65521 ? 359  TRP A CE3 1 
ATOM   2708 C CZ2 . TRP A 1 340 ? -28.68451 11.72754  -25.62240 1.000 25.24181 ? 359  TRP A CZ2 1 
ATOM   2709 C CZ3 . TRP A 1 340 ? -28.73501 13.96562  -26.52878 1.000 25.79090 ? 359  TRP A CZ3 1 
ATOM   2710 C CH2 . TRP A 1 340 ? -29.24543 12.97273  -25.68350 1.000 27.74637 ? 359  TRP A CH2 1 
ATOM   2711 N N   . ALA A 1 341 ? -24.34692 10.44452  -31.21068 1.000 16.98144 ? 360  ALA A N   1 
ATOM   2712 C CA  . ALA A 1 341 ? -24.21121 9.07385   -31.68263 1.000 20.69671 ? 360  ALA A CA  1 
ATOM   2713 C C   . ALA A 1 341 ? -22.85815 8.55889   -31.24362 1.000 18.77061 ? 360  ALA A C   1 
ATOM   2714 O O   . ALA A 1 341 ? -21.87749 9.30605   -31.25473 1.000 17.81887 ? 360  ALA A O   1 
ATOM   2715 C CB  . ALA A 1 341 ? -24.32370 8.96958   -33.21043 1.000 17.50494 ? 360  ALA A CB  1 
ATOM   2716 N N   . ALA A 1 342 ? -22.80642 7.27411   -30.89133 1.000 17.54022 ? 361  ALA A N   1 
ATOM   2717 C CA  . ALA A 1 342 ? -21.57408 6.63516   -30.47025 1.000 18.06128 ? 361  ALA A CA  1 
ATOM   2718 C C   . ALA A 1 342 ? -21.41449 5.31028   -31.20083 1.000 18.34496 ? 361  ALA A C   1 
ATOM   2719 O O   . ALA A 1 342 ? -22.39066 4.63294   -31.52108 1.000 20.09835 ? 361  ALA A O   1 
ATOM   2720 C CB  . ALA A 1 342 ? -21.55810 6.38057   -28.95436 1.000 16.17876 ? 361  ALA A CB  1 
ATOM   2721 N N   . SER A 1 343 ? -20.18105 4.95644   -31.44286 1.000 18.83342 ? 362  SER A N   1 
ATOM   2722 C CA  . SER A 1 343 ? -19.77511 3.66901   -31.98056 1.000 18.30265 ? 362  SER A CA  1 
ATOM   2723 C C   . SER A 1 343 ? -18.53709 3.24609   -31.20401 1.000 21.59366 ? 362  SER A C   1 
ATOM   2724 O O   . SER A 1 343 ? -18.05786 4.02236   -30.36695 1.000 17.65510 ? 362  SER A O   1 
ATOM   2725 C CB  . SER A 1 343 ? -19.49384 3.78676   -33.47214 1.000 15.54143 ? 362  SER A CB  1 
ATOM   2726 O OG  . SER A 1 343 ? -18.15788 4.19310   -33.65182 1.000 16.49640 ? 362  SER A OG  1 
ATOM   2727 N N   . PRO A 1 344 ? -17.99850 2.03809   -31.41767 1.000 18.76540 ? 363  PRO A N   1 
ATOM   2728 C CA  . PRO A 1 344 ? -16.75311 1.66198   -30.72109 1.000 21.76975 ? 363  PRO A CA  1 
ATOM   2729 C C   . PRO A 1 344 ? -15.52300 2.45188   -31.13674 1.000 21.31181 ? 363  PRO A C   1 
ATOM   2730 O O   . PRO A 1 344 ? -14.48120 2.29835   -30.48629 1.000 21.81670 ? 363  PRO A O   1 
ATOM   2731 C CB  . PRO A 1 344 ? -16.59354 0.17076   -31.06502 1.000 23.12827 ? 363  PRO A CB  1 
ATOM   2732 C CG  . PRO A 1 344 ? -17.99299 -0.28937  -31.30904 1.000 23.69506 ? 363  PRO A CG  1 
ATOM   2733 C CD  . PRO A 1 344 ? -18.68246 0.86204   -31.98421 1.000 20.88173 ? 363  PRO A CD  1 
ATOM   2734 N N   . LYS A 1 345 ? -15.58794 3.26841   -32.19150 1.000 16.18640 ? 364  LYS A N   1 
ATOM   2735 C CA  . LYS A 1 345 ? -14.43542 4.02522   -32.64738 1.000 20.24626 ? 364  LYS A CA  1 
ATOM   2736 C C   . LYS A 1 345 ? -14.63550 5.53761   -32.67863 1.000 15.59999 ? 364  LYS A C   1 
ATOM   2737 O O   . LYS A 1 345 ? -13.64792 6.26172   -32.85328 1.000 15.07731 ? 364  LYS A O   1 
ATOM   2738 C CB  . LYS A 1 345 ? -13.99459 3.58295   -34.05711 1.000 24.87825 ? 364  LYS A CB  1 
ATOM   2739 C CG  . LYS A 1 345 ? -13.61093 2.10868   -34.20741 1.000 33.89996 ? 364  LYS A CG  1 
ATOM   2740 C CD  . LYS A 1 345 ? -13.82678 1.61695   -35.64887 1.000 37.46991 ? 364  LYS A CD  1 
ATOM   2741 C CE  . LYS A 1 345 ? -13.47023 2.70736   -36.66260 1.000 37.33121 ? 364  LYS A CE  1 
ATOM   2742 N NZ  . LYS A 1 345 ? -13.02787 2.17724   -37.99203 1.000 37.39444 ? 364  LYS A NZ  1 
ATOM   2743 N N   . SER A 1 346 ? -15.86231 6.04017   -32.53472 1.000 15.78746 ? 365  SER A N   1 
ATOM   2744 C CA  . SER A 1 346 ? -16.07844 7.47204   -32.69523 1.000 16.00505 ? 365  SER A CA  1 
ATOM   2745 C C   . SER A 1 346 ? -17.27442 7.95081   -31.88751 1.000 16.55232 ? 365  SER A C   1 
ATOM   2746 O O   . SER A 1 346 ? -18.06853 7.16577   -31.36448 1.000 15.07175 ? 365  SER A O   1 
ATOM   2747 C CB  . SER A 1 346 ? -16.22864 7.83956   -34.18411 1.000 17.82785 ? 365  SER A CB  1 
ATOM   2748 O OG  . SER A 1 346 ? -17.45062 7.38445   -34.73423 1.000 16.27924 ? 365  SER A OG  1 
ATOM   2749 N N   . PHE A 1 347 ? -17.39323 9.27635   -31.80748 1.000 15.25164 ? 366  PHE A N   1 
ATOM   2750 C CA  . PHE A 1 347 ? -18.48625 9.93594   -31.10693 1.000 11.33279 ? 366  PHE A CA  1 
ATOM   2751 C C   . PHE A 1 347 ? -18.80072 11.21404  -31.87764 1.000 14.59021 ? 366  PHE A C   1 
ATOM   2752 O O   . PHE A 1 347 ? -17.87496 11.93758  -32.25507 1.000 15.28617 ? 366  PHE A O   1 
ATOM   2753 C CB  . PHE A 1 347 ? -18.09993 10.25890  -29.64966 1.000 15.89127 ? 366  PHE A CB  1 
ATOM   2754 C CG  . PHE A 1 347 ? -19.12698 11.06036  -28.95332 1.000 14.10013 ? 366  PHE A CG  1 
ATOM   2755 C CD1 . PHE A 1 347 ? -20.30030 10.46266  -28.50987 1.000 16.54978 ? 366  PHE A CD1 1 
ATOM   2756 C CD2 . PHE A 1 347 ? -18.97388 12.43995  -28.82174 1.000 15.13536 ? 366  PHE A CD2 1 
ATOM   2757 C CE1 . PHE A 1 347 ? -21.28157 11.21821  -27.90825 1.000 15.92217 ? 366  PHE A CE1 1 
ATOM   2758 C CE2 . PHE A 1 347 ? -19.96076 13.19635  -28.22253 1.000 13.84245 ? 366  PHE A CE2 1 
ATOM   2759 C CZ  . PHE A 1 347 ? -21.11122 12.58724  -27.76133 1.000 16.84652 ? 366  PHE A CZ  1 
ATOM   2760 N N   . THR A 1 348 ? -20.08271 11.47872  -32.12113 1.000 15.08945 ? 367  THR A N   1 
ATOM   2761 C CA  . THR A 1 348 ? -20.48918 12.60151  -32.95128 1.000 14.32575 ? 367  THR A CA  1 
ATOM   2762 C C   . THR A 1 348 ? -21.65374 13.34845  -32.32193 1.000 13.11610 ? 367  THR A C   1 
ATOM   2763 O O   . THR A 1 348 ? -22.58541 12.73179  -31.79783 1.000 15.64646 ? 367  THR A O   1 
ATOM   2764 C CB  . THR A 1 348 ? -20.87297 12.11788  -34.34893 1.000 15.96302 ? 367  THR A CB  1 
ATOM   2765 O OG1 . THR A 1 348 ? -19.75029 11.43484  -34.91222 1.000 15.21367 ? 367  THR A OG1 1 
ATOM   2766 C CG2 . THR A 1 348 ? -21.24979 13.27474  -35.23349 1.000 10.81553 ? 367  THR A CG2 1 
ATOM   2767 N N   . LEU A 1 349 ? -21.59864 14.68563  -32.39626 1.000 14.09954 ? 368  LEU A N   1 
ATOM   2768 C CA  . LEU A 1 349 ? -22.64875 15.56639  -31.91595 1.000 13.14225 ? 368  LEU A CA  1 
ATOM   2769 C C   . LEU A 1 349 ? -23.24688 16.35253  -33.08374 1.000 14.04890 ? 368  LEU A C   1 
ATOM   2770 O O   . LEU A 1 349 ? -22.51832 16.84351  -33.94762 1.000 14.42963 ? 368  LEU A O   1 
ATOM   2771 C CB  . LEU A 1 349 ? -22.07889 16.55036  -30.89761 1.000 17.55020 ? 368  LEU A CB  1 
ATOM   2772 C CG  . LEU A 1 349 ? -21.76788 16.02860  -29.49129 1.000 17.54393 ? 368  LEU A CG  1 
ATOM   2773 C CD1 . LEU A 1 349 ? -20.97208 17.12174  -28.79068 1.000 19.29941 ? 368  LEU A CD1 1 
ATOM   2774 C CD2 . LEU A 1 349 ? -23.03214 15.71304  -28.71723 1.000 17.18073 ? 368  LEU A CD2 1 
ATOM   2775 N N   . ASP A 1 350 ? -24.56778 16.50479  -33.06222 1.000 16.49362 ? 369  ASP A N   1 
ATOM   2776 C CA  . ASP A 1 350 ? -25.33904 17.27610  -34.03516 1.000 16.47013 ? 369  ASP A CA  1 
ATOM   2777 C C   . ASP A 1 350 ? -25.98254 18.42197  -33.26565 1.000 18.00858 ? 369  ASP A C   1 
ATOM   2778 O O   . ASP A 1 350 ? -26.74042 18.17803  -32.32117 1.000 16.55378 ? 369  ASP A O   1 
ATOM   2779 C CB  . ASP A 1 350 ? -26.37338 16.35434  -34.70439 1.000 18.08019 ? 369  ASP A CB  1 
ATOM   2780 C CG  . ASP A 1 350 ? -27.37313 17.07340  -35.62209 1.000 19.64302 ? 369  ASP A CG  1 
ATOM   2781 O OD1 . ASP A 1 350 ? -27.24884 18.28351  -35.90757 1.000 16.48147 ? 369  ASP A OD1 1 
ATOM   2782 O OD2 . ASP A 1 350 ? -28.28534 16.35800  -36.10942 1.000 21.02860 ? 369  ASP A OD2 1 
ATOM   2783 N N   . PHE A 1 351 ? -25.62516 19.66359  -33.62533 1.000 15.06919 ? 370  PHE A N   1 
ATOM   2784 C CA  . PHE A 1 351 ? -26.13123 20.86679  -32.96718 1.000 17.12680 ? 370  PHE A CA  1 
ATOM   2785 C C   . PHE A 1 351 ? -27.25705 21.53752  -33.75028 1.000 21.17722 ? 370  PHE A C   1 
ATOM   2786 O O   . PHE A 1 351 ? -27.56398 22.71640  -33.50594 1.000 18.72582 ? 370  PHE A O   1 
ATOM   2787 C CB  . PHE A 1 351 ? -24.99602 21.86382  -32.72720 1.000 18.06026 ? 370  PHE A CB  1 
ATOM   2788 C CG  . PHE A 1 351 ? -23.80866 21.27847  -31.99594 1.000 20.38723 ? 370  PHE A CG  1 
ATOM   2789 C CD1 . PHE A 1 351 ? -23.83808 21.09861  -30.62220 1.000 22.94931 ? 370  PHE A CD1 1 
ATOM   2790 C CD2 . PHE A 1 351 ? -22.67081 20.90527  -32.68588 1.000 22.52688 ? 370  PHE A CD2 1 
ATOM   2791 C CE1 . PHE A 1 351 ? -22.73964 20.56162  -29.95421 1.000 21.22807 ? 370  PHE A CE1 1 
ATOM   2792 C CE2 . PHE A 1 351 ? -21.57415 20.36475  -32.01762 1.000 21.24633 ? 370  PHE A CE2 1 
ATOM   2793 C CZ  . PHE A 1 351 ? -21.61636 20.20199  -30.65421 1.000 19.74727 ? 370  PHE A CZ  1 
ATOM   2794 N N   . GLY A 1 352 ? -27.88002 20.81641  -34.67979 1.000 18.08359 ? 371  GLY A N   1 
ATOM   2795 C CA  . GLY A 1 352 ? -28.96107 21.42101  -35.44180 1.000 20.27736 ? 371  GLY A CA  1 
ATOM   2796 C C   . GLY A 1 352 ? -28.46954 22.68250  -36.12699 1.000 18.06923 ? 371  GLY A C   1 
ATOM   2797 O O   . GLY A 1 352 ? -27.34683 22.73546  -36.64497 1.000 19.31203 ? 371  GLY A O   1 
ATOM   2798 N N   . ASP A 1 353 ? -29.29398 23.73456  -36.09069 1.000 20.33773 ? 372  ASP A N   1 
ATOM   2799 C CA  . ASP A 1 353 ? -28.95088 24.97811  -36.77453 1.000 20.35759 ? 372  ASP A CA  1 
ATOM   2800 C C   . ASP A 1 353 ? -28.11666 25.92261  -35.91828 1.000 21.91759 ? 372  ASP A C   1 
ATOM   2801 O O   . ASP A 1 353 ? -27.93185 27.08424  -36.30111 1.000 20.56621 ? 372  ASP A O   1 
ATOM   2802 C CB  . ASP A 1 353 ? -30.20546 25.70647  -37.27359 1.000 21.66292 ? 372  ASP A CB  1 
ATOM   2803 C CG  . ASP A 1 353 ? -31.28739 25.81872  -36.22576 1.000 24.75431 ? 372  ASP A CG  1 
ATOM   2804 O OD1 . ASP A 1 353 ? -31.04311 25.44324  -35.06158 1.000 21.31046 ? 372  ASP A OD1 1 
ATOM   2805 O OD2 . ASP A 1 353 ? -32.39826 26.30288  -36.57252 1.000 25.78953 ? 372  ASP A OD2 1 
ATOM   2806 N N   . TYR A 1 354 ? -27.59111 25.45472  -34.78297 1.000 19.22566 ? 373  TYR A N   1 
ATOM   2807 C CA  . TYR A 1 354 ? -26.65361 26.26709  -34.01150 1.000 19.31807 ? 373  TYR A CA  1 
ATOM   2808 C C   . TYR A 1 354 ? -25.30279 26.40646  -34.69297 1.000 21.56947 ? 373  TYR A C   1 
ATOM   2809 O O   . TYR A 1 354 ? -24.54243 27.31429  -34.34122 1.000 25.17256 ? 373  TYR A O   1 
ATOM   2810 C CB  . TYR A 1 354 ? -26.48113 25.68358  -32.60634 1.000 20.65844 ? 373  TYR A CB  1 
ATOM   2811 C CG  . TYR A 1 354 ? -27.69543 25.97146  -31.76279 1.000 19.64465 ? 373  TYR A CG  1 
ATOM   2812 C CD1 . TYR A 1 354 ? -27.82701 27.17402  -31.07453 1.000 22.85401 ? 373  TYR A CD1 1 
ATOM   2813 C CD2 . TYR A 1 354 ? -28.74708 25.07290  -31.71794 1.000 19.45561 ? 373  TYR A CD2 1 
ATOM   2814 C CE1 . TYR A 1 354 ? -28.97507 27.44725  -30.31974 1.000 19.75338 ? 373  TYR A CE1 1 
ATOM   2815 C CE2 . TYR A 1 354 ? -29.88921 25.33499  -30.97830 1.000 21.71754 ? 373  TYR A CE2 1 
ATOM   2816 C CZ  . TYR A 1 354 ? -29.99651 26.51993  -30.28710 1.000 21.11802 ? 373  TYR A CZ  1 
ATOM   2817 O OH  . TYR A 1 354 ? -31.14322 26.75450  -29.57840 1.000 20.67082 ? 373  TYR A OH  1 
ATOM   2818 N N   . GLN A 1 355 ? -24.98307 25.53864  -35.65077 1.000 25.25286 ? 374  GLN A N   1 
ATOM   2819 C CA  . GLN A 1 355 ? -23.72669 25.64507  -36.38137 1.000 25.85513 ? 374  GLN A CA  1 
ATOM   2820 C C   . GLN A 1 355 ? -23.80275 24.75091  -37.60911 1.000 24.09995 ? 374  GLN A C   1 
ATOM   2821 O O   . GLN A 1 355 ? -24.64660 23.85560  -37.69583 1.000 22.72079 ? 374  GLN A O   1 
ATOM   2822 C CB  . GLN A 1 355 ? -22.52095 25.26350  -35.51101 1.000 25.97198 ? 374  GLN A CB  1 
ATOM   2823 C CG  . GLN A 1 355 ? -22.45840 23.79112  -35.10900 1.000 27.16169 ? 374  GLN A CG  1 
ATOM   2824 C CD  . GLN A 1 355 ? -21.11287 23.42307  -34.49961 1.000 29.42959 ? 374  GLN A CD  1 
ATOM   2825 O OE1 . GLN A 1 355 ? -20.69255 24.01534  -33.50470 1.000 31.57715 ? 374  GLN A OE1 1 
ATOM   2826 N NE2 . GLN A 1 355 ? -20.43703 22.44714  -35.09011 1.000 23.85925 ? 374  GLN A NE2 1 
ATOM   2827 N N   . ASP A 1 356 ? -22.91587 25.01477  -38.56194 1.000 28.08819 ? 375  ASP A N   1 
ATOM   2828 C CA  . ASP A 1 356 ? -22.79609 24.17708  -39.74392 1.000 30.48801 ? 375  ASP A CA  1 
ATOM   2829 C C   . ASP A 1 356 ? -21.77842 23.08249  -39.46244 1.000 30.76779 ? 375  ASP A C   1 
ATOM   2830 O O   . ASP A 1 356 ? -20.66495 23.35737  -39.00205 1.000 35.58713 ? 375  ASP A O   1 
ATOM   2831 C CB  . ASP A 1 356 ? -22.38058 24.99267  -40.96980 1.000 37.07750 ? 375  ASP A CB  1 
ATOM   2832 N N   . GLY A 1 357 ? -22.16846 21.84383  -39.71664 1.000 30.49222 ? 376  GLY A N   1 
ATOM   2833 C CA  . GLY A 1 357 ? -21.25508 20.74852  -39.49182 1.000 24.26723 ? 376  GLY A CA  1 
ATOM   2834 C C   . GLY A 1 357 ? -21.41413 20.10636  -38.12816 1.000 23.02910 ? 376  GLY A C   1 
ATOM   2835 O O   . GLY A 1 357 ? -21.74178 20.76737  -37.13158 1.000 20.08716 ? 376  GLY A O   1 
ATOM   2836 N N   . TYR A 1 358 ? -21.20343 18.80566  -38.08595 1.000 19.22301 ? 377  TYR A N   1 
ATOM   2837 C CA  . TYR A 1 358 ? -21.21457 18.04711  -36.84815 1.000 16.97450 ? 377  TYR A CA  1 
ATOM   2838 C C   . TYR A 1 358 ? -19.83866 18.11665  -36.19112 1.000 18.99007 ? 377  TYR A C   1 
ATOM   2839 O O   . TYR A 1 358 ? -18.82518 18.38834  -36.83777 1.000 18.63354 ? 377  TYR A O   1 
ATOM   2840 C CB  . TYR A 1 358 ? -21.55949 16.58400  -37.13437 1.000 16.70026 ? 377  TYR A CB  1 
ATOM   2841 C CG  . TYR A 1 358 ? -22.93309 16.30635  -37.73196 1.000 21.19863 ? 377  TYR A CG  1 
ATOM   2842 C CD1 . TYR A 1 358 ? -23.98828 17.20671  -37.60895 1.000 18.73929 ? 377  TYR A CD1 1 
ATOM   2843 C CD2 . TYR A 1 358 ? -23.15418 15.13347  -38.45720 1.000 17.85341 ? 377  TYR A CD2 1 
ATOM   2844 C CE1 . TYR A 1 358 ? -25.23395 16.92469  -38.16111 1.000 20.64223 ? 377  TYR A CE1 1 
ATOM   2845 C CE2 . TYR A 1 358 ? -24.37427 14.85325  -39.01943 1.000 22.05403 ? 377  TYR A CE2 1 
ATOM   2846 C CZ  . TYR A 1 358 ? -25.41892 15.74899  -38.86634 1.000 23.49766 ? 377  TYR A CZ  1 
ATOM   2847 O OH  . TYR A 1 358 ? -26.63906 15.45271  -39.43142 1.000 28.25347 ? 377  TYR A OH  1 
ATOM   2848 N N   . TYR A 1 359 ? -19.80554 17.82271  -34.89459 1.000 16.58365 ? 378  TYR A N   1 
ATOM   2849 C CA  . TYR A 1 359 ? -18.55637 17.59663  -34.17439 1.000 18.22700 ? 378  TYR A CA  1 
ATOM   2850 C C   . TYR A 1 359 ? -18.35907 16.08378  -34.06631 1.000 15.20447 ? 378  TYR A C   1 
ATOM   2851 O O   . TYR A 1 359 ? -19.11370 15.40579  -33.36034 1.000 14.55625 ? 378  TYR A O   1 
ATOM   2852 C CB  . TYR A 1 359 ? -18.61389 18.26351  -32.80438 1.000 16.54137 ? 378  TYR A CB  1 
ATOM   2853 C CG  . TYR A 1 359 ? -17.38638 18.06452  -31.94772 1.000 15.55123 ? 378  TYR A CG  1 
ATOM   2854 C CD1 . TYR A 1 359 ? -16.19300 18.71182  -32.23672 1.000 18.26006 ? 378  TYR A CD1 1 
ATOM   2855 C CD2 . TYR A 1 359 ? -17.43036 17.22071  -30.84308 1.000 15.86087 ? 378  TYR A CD2 1 
ATOM   2856 C CE1 . TYR A 1 359 ? -15.07793 18.53777  -31.44752 1.000 20.29693 ? 378  TYR A CE1 1 
ATOM   2857 C CE2 . TYR A 1 359 ? -16.30606 17.03590  -30.04534 1.000 15.41797 ? 378  TYR A CE2 1 
ATOM   2858 C CZ  . TYR A 1 359 ? -15.14760 17.70243  -30.34789 1.000 16.83738 ? 378  TYR A CZ  1 
ATOM   2859 O OH  . TYR A 1 359 ? -14.03489 17.52303  -29.56160 1.000 17.87872 ? 378  TYR A OH  1 
ATOM   2860 N N   . SER A 1 360 ? -17.34943 15.54856  -34.76262 1.000 16.15961 ? 379  SER A N   1 
ATOM   2861 C CA  . SER A 1 360 ? -17.17039 14.10023  -34.86883 1.000 14.54694 ? 379  SER A CA  1 
ATOM   2862 C C   . SER A 1 360 ? -15.71855 13.75674  -34.56463 1.000 17.37038 ? 379  SER A C   1 
ATOM   2863 O O   . SER A 1 360 ? -14.80771 14.21630  -35.26789 1.000 18.75539 ? 379  SER A O   1 
ATOM   2864 C CB  . SER A 1 360 ? -17.57390 13.60735  -36.26750 1.000 13.98837 ? 379  SER A CB  1 
ATOM   2865 O OG  . SER A 1 360 ? -17.62597 12.18621  -36.35936 1.000 18.45343 ? 379  SER A OG  1 
ATOM   2866 N N   . VAL A 1 361 ? -15.49475 12.95612  -33.52034 1.000 15.42644 ? 380  VAL A N   1 
ATOM   2867 C CA  . VAL A 1 361 ? -14.14364 12.74972  -33.01061 1.000 17.97062 ? 380  VAL A CA  1 
ATOM   2868 C C   . VAL A 1 361 ? -13.88764 11.26006  -32.87279 1.000 17.10122 ? 380  VAL A C   1 
ATOM   2869 O O   . VAL A 1 361 ? -14.81077 10.47888  -32.62227 1.000 15.10247 ? 380  VAL A O   1 
ATOM   2870 C CB  . VAL A 1 361 ? -13.94172 13.44626  -31.64464 1.000 16.81866 ? 380  VAL A CB  1 
ATOM   2871 C CG1 . VAL A 1 361 ? -13.91756 14.97633  -31.83133 1.000 17.98910 ? 380  VAL A CG1 1 
ATOM   2872 C CG2 . VAL A 1 361 ? -15.01207 13.00613  -30.62768 1.000 14.21398 ? 380  VAL A CG2 1 
ATOM   2873 N N   . GLN A 1 362 ? -12.62075 10.86432  -32.99806 1.000 15.90819 ? 381  GLN A N   1 
ATOM   2874 C CA  . GLN A 1 362 ? -12.25971 9.46160   -32.82479 1.000 18.21847 ? 381  GLN A CA  1 
ATOM   2875 C C   . GLN A 1 362 ? -11.98970 9.22502   -31.33739 1.000 16.78212 ? 381  GLN A C   1 
ATOM   2876 O O   . GLN A 1 362 ? -11.29529 10.02661  -30.69515 1.000 17.77778 ? 381  GLN A O   1 
ATOM   2877 C CB  . GLN A 1 362 ? -11.02266 9.10374   -33.65232 1.000 18.48519 ? 381  GLN A CB  1 
ATOM   2878 C CG  . GLN A 1 362 ? -11.18270 9.37098   -35.18125 1.000 23.60000 ? 381  GLN A CG  1 
ATOM   2879 C CD  . GLN A 1 362 ? -12.51383 8.91006   -35.78116 1.000 26.30574 ? 381  GLN A CD  1 
ATOM   2880 O OE1 . GLN A 1 362 ? -13.32335 9.73824   -36.21640 1.000 26.52047 ? 381  GLN A OE1 1 
ATOM   2881 N NE2 . GLN A 1 362 ? -12.73113 7.59964   -35.83679 1.000 21.10049 ? 381  GLN A NE2 1 
ATOM   2882 N N   . THR A 1 363 ? -12.52697 8.13085   -30.80282 1.000 15.27922 ? 382  THR A N   1 
ATOM   2883 C CA  . THR A 1 363 ? -12.41413 7.77473   -29.39281 1.000 16.96087 ? 382  THR A CA  1 
ATOM   2884 C C   . THR A 1 363 ? -12.91428 6.35156   -29.20951 1.000 16.88439 ? 382  THR A C   1 
ATOM   2885 O O   . THR A 1 363 ? -13.83537 5.91325   -29.91188 1.000 18.92370 ? 382  THR A O   1 
ATOM   2886 C CB  . THR A 1 363 ? -13.24158 8.71797   -28.50266 1.000 18.16237 ? 382  THR A CB  1 
ATOM   2887 O OG1 . THR A 1 363 ? -13.30793 8.18293   -27.17620 1.000 17.60955 ? 382  THR A OG1 1 
ATOM   2888 C CG2 . THR A 1 363 ? -14.65049 8.82904   -29.03769 1.000 14.08375 ? 382  THR A CG2 1 
ATOM   2889 N N   . THR A 1 364 ? -12.30899 5.62977   -28.26711 1.000 20.23564 ? 383  THR A N   1 
ATOM   2890 C CA  . THR A 1 364 ? -12.83964 4.32889   -27.86607 1.000 19.38467 ? 383  THR A CA  1 
ATOM   2891 C C   . THR A 1 364 ? -13.77004 4.42803   -26.65447 1.000 17.05930 ? 383  THR A C   1 
ATOM   2892 O O   . THR A 1 364 ? -14.24405 3.39640   -26.15540 1.000 18.55800 ? 383  THR A O   1 
ATOM   2893 C CB  . THR A 1 364 ? -11.69862 3.32601   -27.58353 1.000 21.39034 ? 383  THR A CB  1 
ATOM   2894 O OG1 . THR A 1 364 ? -10.81378 3.84651   -26.58159 1.000 20.11217 ? 383  THR A OG1 1 
ATOM   2895 C CG2 . THR A 1 364 ? -10.90066 3.03929   -28.85113 1.000 23.06813 ? 383  THR A CG2 1 
ATOM   2896 N N   . GLU A 1 365 ? -14.05865 5.64048   -26.18372 1.000 17.26930 ? 384  GLU A N   1 
ATOM   2897 C CA  A GLU A 1 365 ? -14.96837 5.85355   -25.06541 0.746 17.41249 ? 384  GLU A CA  1 
ATOM   2898 C CA  B GLU A 1 365 ? -14.96079 5.87507   -25.05937 0.254 17.48427 ? 384  GLU A CA  1 
ATOM   2899 C C   . GLU A 1 365 ? -16.26487 6.55628   -25.48136 1.000 17.23958 ? 384  GLU A C   1 
ATOM   2900 O O   . GLU A 1 365 ? -16.90613 7.22168   -24.66042 1.000 16.06235 ? 384  GLU A O   1 
ATOM   2901 C CB  A GLU A 1 365 ? -14.25664 6.64247   -23.97042 0.746 17.98849 ? 384  GLU A CB  1 
ATOM   2902 C CB  B GLU A 1 365 ? -14.27813 6.72496   -23.98632 0.254 18.05109 ? 384  GLU A CB  1 
ATOM   2903 C CG  A GLU A 1 365 ? -13.02141 5.95308   -23.38844 0.746 21.04245 ? 384  GLU A CG  1 
ATOM   2904 C CG  B GLU A 1 365 ? -13.07402 6.11346   -23.27516 0.254 21.23767 ? 384  GLU A CG  1 
ATOM   2905 C CD  A GLU A 1 365 ? -12.23789 6.86036   -22.47167 0.746 26.86033 ? 384  GLU A CD  1 
ATOM   2906 C CD  B GLU A 1 365 ? -11.77753 6.33344   -24.03158 0.254 24.32356 ? 384  GLU A CD  1 
ATOM   2907 O OE1 A GLU A 1 365 ? -11.58105 7.79985   -22.99079 0.746 20.37554 ? 384  GLU A OE1 1 
ATOM   2908 O OE1 B GLU A 1 365 ? -11.81987 6.89165   -25.14548 0.254 24.27322 ? 384  GLU A OE1 1 
ATOM   2909 O OE2 A GLU A 1 365 ? -12.32184 6.67859   -21.23347 0.746 23.16276 ? 384  GLU A OE2 1 
ATOM   2910 O OE2 B GLU A 1 365 ? -10.70826 6.00691   -23.48554 0.254 29.59778 ? 384  GLU A OE2 1 
ATOM   2911 N N   . GLY A 1 366 ? -16.66496 6.42092   -26.74749 1.000 16.59287 ? 385  GLY A N   1 
ATOM   2912 C CA  . GLY A 1 366 ? -17.86582 7.10728   -27.20983 1.000 14.62345 ? 385  GLY A CA  1 
ATOM   2913 C C   . GLY A 1 366 ? -19.11637 6.72045   -26.43834 1.000 15.17844 ? 385  GLY A C   1 
ATOM   2914 O O   . GLY A 1 366 ? -19.94096 7.57905   -26.10547 1.000 16.61069 ? 385  GLY A O   1 
ATOM   2915 N N   . GLU A 1 367 ? -19.27461 5.42569   -26.13107 1.000 15.40213 ? 386  GLU A N   1 
ATOM   2916 C CA  . GLU A 1 367 ? -20.45494 4.99576   -25.37959 1.000 16.99084 ? 386  GLU A CA  1 
ATOM   2917 C C   . GLU A 1 367 ? -20.47880 5.62220   -23.98614 1.000 16.82537 ? 386  GLU A C   1 
ATOM   2918 O O   . GLU A 1 367 ? -21.53742 6.05147   -23.51467 1.000 19.52286 ? 386  GLU A O   1 
ATOM   2919 C CB  . GLU A 1 367 ? -20.50446 3.46598   -25.30241 1.000 18.40572 ? 386  GLU A CB  1 
ATOM   2920 C CG  . GLU A 1 367 ? -21.78964 2.87095   -24.67123 1.000 22.17866 ? 386  GLU A CG  1 
ATOM   2921 C CD  . GLU A 1 367 ? -23.08825 3.24313   -25.38730 1.000 23.17774 ? 386  GLU A CD  1 
ATOM   2922 O OE1 . GLU A 1 367 ? -23.03709 3.47954   -26.60440 1.000 23.25113 ? 386  GLU A OE1 1 
ATOM   2923 O OE2 . GLU A 1 367 ? -24.15419 3.27985   -24.72041 1.000 22.50339 ? 386  GLU A OE2 1 
ATOM   2924 N N   . GLN A 1 368 ? -19.32267 5.67619   -23.30840 1.000 16.01400 ? 387  GLN A N   1 
ATOM   2925 C CA  A GLN A 1 368 ? -19.22733 6.39270   -22.03529 0.452 17.66691 ? 387  GLN A CA  1 
ATOM   2926 C CA  B GLN A 1 368 ? -19.25814 6.37847   -22.03091 0.548 17.66026 ? 387  GLN A CA  1 
ATOM   2927 C C   . GLN A 1 368 ? -19.74932 7.81487   -22.17278 1.000 17.68788 ? 387  GLN A C   1 
ATOM   2928 O O   . GLN A 1 368 ? -20.56514 8.28664   -21.36856 1.000 17.67161 ? 387  GLN A O   1 
ATOM   2929 C CB  A GLN A 1 368 ? -17.77509 6.46722   -21.55205 0.452 18.71974 ? 387  GLN A CB  1 
ATOM   2930 C CB  B GLN A 1 368 ? -17.82765 6.36744   -21.49407 0.548 18.73284 ? 387  GLN A CB  1 
ATOM   2931 C CG  A GLN A 1 368 ? -17.12004 5.22767   -20.99608 0.452 20.48642 ? 387  GLN A CG  1 
ATOM   2932 C CG  B GLN A 1 368 ? -17.31598 5.00996   -21.07758 0.548 20.33283 ? 387  GLN A CG  1 
ATOM   2933 C CD  A GLN A 1 368 ? -16.00970 5.61005   -20.01762 0.452 20.37413 ? 387  GLN A CD  1 
ATOM   2934 C CD  B GLN A 1 368 ? -16.57916 4.27544   -22.17168 0.548 20.65798 ? 387  GLN A CD  1 
ATOM   2935 O OE1 A GLN A 1 368 ? -16.22992 6.41373   -19.10613 0.452 20.74974 ? 387  GLN A OE1 1 
ATOM   2936 O OE1 B GLN A 1 368 ? -17.08481 4.11603   -23.29101 0.548 20.42996 ? 387  GLN A OE1 1 
ATOM   2937 N NE2 A GLN A 1 368 ? -14.82087 5.04990   -20.20590 0.452 22.31638 ? 387  GLN A NE2 1 
ATOM   2938 N NE2 B GLN A 1 368 ? -15.36659 3.81147   -21.85368 0.548 16.90982 ? 387  GLN A NE2 1 
ATOM   2939 N N   . ILE A 1 369 ? -19.23795 8.52783   -23.17649 1.000 13.00448 ? 388  ILE A N   1 
ATOM   2940 C CA  . ILE A 1 369 ? -19.59842 9.92418   -23.38274 1.000 14.07797 ? 388  ILE A CA  1 
ATOM   2941 C C   . ILE A 1 369 ? -21.08875 10.05934  -23.63860 1.000 15.14624 ? 388  ILE A C   1 
ATOM   2942 O O   . ILE A 1 369 ? -21.76492 10.90537  -23.04087 1.000 15.00454 ? 388  ILE A O   1 
ATOM   2943 C CB  . ILE A 1 369 ? -18.76156 10.52232  -24.52989 1.000 12.95252 ? 388  ILE A CB  1 
ATOM   2944 C CG1 . ILE A 1 369 ? -17.25621 10.40003  -24.19902 1.000 14.01373 ? 388  ILE A CG1 1 
ATOM   2945 C CG2 . ILE A 1 369 ? -19.15920 11.95903  -24.77608 1.000 16.29197 ? 388  ILE A CG2 1 
ATOM   2946 C CD1 . ILE A 1 369 ? -16.30906 10.61149  -25.39222 1.000 14.36715 ? 388  ILE A CD1 1 
ATOM   2947 N N   . ALA A 1 370 ? -21.61459 9.23791   -24.55032 1.000 16.65204 ? 389  ALA A N   1 
ATOM   2948 C CA  . ALA A 1 370 ? -23.03559 9.26944   -24.87798 1.000 16.06729 ? 389  ALA A CA  1 
ATOM   2949 C C   . ALA A 1 370 ? -23.90544 9.04283   -23.64695 1.000 14.61179 ? 389  ALA A C   1 
ATOM   2950 O O   . ALA A 1 370 ? -24.91333 9.73661   -23.45267 1.000 15.29627 ? 389  ALA A O   1 
ATOM   2951 C CB  . ALA A 1 370 ? -23.32784 8.21455   -25.94252 1.000 15.23032 ? 389  ALA A CB  1 
ATOM   2952 N N   . GLN A 1 371 ? -23.54077 8.07242   -22.80199 1.000 17.91900 ? 390  GLN A N   1 
ATOM   2953 C CA  . GLN A 1 371 ? -24.38600 7.77007   -21.64531 1.000 16.88589 ? 390  GLN A CA  1 
ATOM   2954 C C   . GLN A 1 371 ? -24.33804 8.86558   -20.59580 1.000 20.03273 ? 390  GLN A C   1 
ATOM   2955 O O   . GLN A 1 371 ? -25.33678 9.10011   -19.90343 1.000 19.80854 ? 390  GLN A O   1 
ATOM   2956 C CB  . GLN A 1 371 ? -23.99717 6.42373   -21.02305 1.000 18.96832 ? 390  GLN A CB  1 
ATOM   2957 C CG  . GLN A 1 371 ? -24.20720 5.25308   -21.95046 1.000 17.37743 ? 390  GLN A CG  1 
ATOM   2958 C CD  . GLN A 1 371 ? -24.21287 3.91188   -21.21799 1.000 22.45560 ? 390  GLN A CD  1 
ATOM   2959 O OE1 . GLN A 1 371 ? -24.22264 3.86861   -19.98342 1.000 28.83810 ? 390  GLN A OE1 1 
ATOM   2960 N NE2 . GLN A 1 371 ? -24.16019 2.81752   -21.97588 1.000 22.20237 ? 390  GLN A NE2 1 
ATOM   2961 N N   . LEU A 1 372 ? -23.19735 9.53861   -20.45191 1.000 17.91939 ? 391  LEU A N   1 
ATOM   2962 C CA  . LEU A 1 372 ? -23.12783 10.68367  -19.55123 1.000 17.86290 ? 391  LEU A CA  1 
ATOM   2963 C C   . LEU A 1 372 ? -24.06853 11.78124  -20.01248 1.000 19.98525 ? 391  LEU A C   1 
ATOM   2964 O O   . LEU A 1 372 ? -24.86770 12.30906  -19.23219 1.000 19.25725 ? 391  LEU A O   1 
ATOM   2965 C CB  . LEU A 1 372 ? -21.70061 11.21749  -19.49990 1.000 19.49281 ? 391  LEU A CB  1 
ATOM   2966 C CG  . LEU A 1 372 ? -20.73586 10.68251  -18.45832 1.000 24.58565 ? 391  LEU A CG  1 
ATOM   2967 C CD1 . LEU A 1 372 ? -19.46524 11.52601  -18.49172 1.000 20.55763 ? 391  LEU A CD1 1 
ATOM   2968 C CD2 . LEU A 1 372 ? -21.37124 10.67351  -17.06629 1.000 20.40213 ? 391  LEU A CD2 1 
ATOM   2969 N N   . ILE A 1 373 ? -23.98257 12.14212  -21.29270 1.000 14.34597 ? 392  ILE A N   1 
ATOM   2970 C CA  . ILE A 1 373 ? -24.84945 13.18995  -21.82677 1.000 17.93413 ? 392  ILE A CA  1 
ATOM   2971 C C   . ILE A 1 373 ? -26.31942 12.82268  -21.63690 1.000 21.40247 ? 392  ILE A C   1 
ATOM   2972 O O   . ILE A 1 373 ? -27.11859 13.62911  -21.13817 1.000 19.84645 ? 392  ILE A O   1 
ATOM   2973 C CB  . ILE A 1 373 ? -24.51107 13.44845  -23.30668 1.000 17.29365 ? 392  ILE A CB  1 
ATOM   2974 C CG1 . ILE A 1 373 ? -23.10228 14.03798  -23.43163 1.000 16.67798 ? 392  ILE A CG1 1 
ATOM   2975 C CG2 . ILE A 1 373 ? -25.58442 14.30547  -23.97004 1.000 19.58943 ? 392  ILE A CG2 1 
ATOM   2976 C CD1 . ILE A 1 373 ? -22.58040 14.14069  -24.88455 1.000 14.49984 ? 392  ILE A CD1 1 
ATOM   2977 N N   . ALA A 1 374 ? -26.70197 11.60690  -22.05099 1.000 19.63968 ? 393  ALA A N   1 
ATOM   2978 C CA  . ALA A 1 374 ? -28.09215 11.18538  -21.91870 1.000 20.16962 ? 393  ALA A CA  1 
ATOM   2979 C C   . ALA A 1 374 ? -28.53302 11.21847  -20.46277 1.000 24.32321 ? 393  ALA A C   1 
ATOM   2980 O O   . ALA A 1 374 ? -29.65992 11.63180  -20.15630 1.000 24.12270 ? 393  ALA A O   1 
ATOM   2981 C CB  . ALA A 1 374 ? -28.28961 9.78310   -22.50407 1.000 18.82412 ? 393  ALA A CB  1 
ATOM   2982 N N   . GLY A 1 375 ? -27.65182 10.79015  -19.55546 1.000 22.19122 ? 394  GLY A N   1 
ATOM   2983 C CA  . GLY A 1 375 ? -27.99315 10.78250  -18.14132 1.000 22.48649 ? 394  GLY A CA  1 
ATOM   2984 C C   . GLY A 1 375 ? -28.22343 12.17505  -17.59266 1.000 26.32615 ? 394  GLY A C   1 
ATOM   2985 O O   . GLY A 1 375 ? -29.19535 12.41397  -16.87146 1.000 26.56384 ? 394  GLY A O   1 
ATOM   2986 N N   . TYR A 1 376 ? -27.35074 13.12095  -17.94688 1.000 24.21300 ? 395  TYR A N   1 
ATOM   2987 C CA  . TYR A 1 376 ? -27.53804 14.49270  -17.48401 1.000 22.52325 ? 395  TYR A CA  1 
ATOM   2988 C C   . TYR A 1 376 ? -28.77793 15.12316  -18.09707 1.000 28.49091 ? 395  TYR A C   1 
ATOM   2989 O O   . TYR A 1 376 ? -29.49977 15.86374  -17.41719 1.000 24.96480 ? 395  TYR A O   1 
ATOM   2990 C CB  . TYR A 1 376 ? -26.30974 15.34127  -17.80027 1.000 20.22336 ? 395  TYR A CB  1 
ATOM   2991 C CG  . TYR A 1 376 ? -25.12602 15.00750  -16.92105 1.000 25.12758 ? 395  TYR A CG  1 
ATOM   2992 C CD1 . TYR A 1 376 ? -25.28500 14.85085  -15.54772 1.000 25.94671 ? 395  TYR A CD1 1 
ATOM   2993 C CD2 . TYR A 1 376 ? -23.85927 14.84639  -17.46118 1.000 20.73291 ? 395  TYR A CD2 1 
ATOM   2994 C CE1 . TYR A 1 376 ? -24.21250 14.54917  -14.73679 1.000 26.66567 ? 395  TYR A CE1 1 
ATOM   2995 C CE2 . TYR A 1 376 ? -22.77920 14.53903  -16.66449 1.000 20.58068 ? 395  TYR A CE2 1 
ATOM   2996 C CZ  . TYR A 1 376 ? -22.96365 14.38554  -15.30610 1.000 24.77265 ? 395  TYR A CZ  1 
ATOM   2997 O OH  . TYR A 1 376 ? -21.89547 14.08244  -14.51502 1.000 26.19857 ? 395  TYR A OH  1 
ATOM   2998 N N   . ILE A 1 377 ? -29.03142 14.86188  -19.38252 1.000 21.68035 ? 396  ILE A N   1 
ATOM   2999 C CA  . ILE A 1 377 ? -30.23221 15.40958  -20.01542 1.000 26.28228 ? 396  ILE A CA  1 
ATOM   3000 C C   . ILE A 1 377 ? -31.48065 14.85568  -19.33967 1.000 30.01712 ? 396  ILE A C   1 
ATOM   3001 O O   . ILE A 1 377 ? -32.43226 15.59549  -19.06824 1.000 30.02962 ? 396  ILE A O   1 
ATOM   3002 C CB  . ILE A 1 377 ? -30.23282 15.13970  -21.53672 1.000 27.36870 ? 396  ILE A CB  1 
ATOM   3003 C CG1 . ILE A 1 377 ? -29.37834 16.19414  -22.24609 1.000 26.38200 ? 396  ILE A CG1 1 
ATOM   3004 C CG2 . ILE A 1 377 ? -31.66489 15.19628  -22.10273 1.000 23.98532 ? 396  ILE A CG2 1 
ATOM   3005 C CD1 . ILE A 1 377 ? -28.92919 15.82750  -23.64585 1.000 20.14083 ? 396  ILE A CD1 1 
ATOM   3006 N N   . ARG A 1 378 ? -31.48032 13.55636  -19.01954 1.000 25.56953 ? 397  ARG A N   1 
ATOM   3007 C CA  . ARG A 1 378 ? -32.61297 12.96725  -18.30546 1.000 31.14760 ? 397  ARG A CA  1 
ATOM   3008 C C   . ARG A 1 378 ? -32.88307 13.69021  -16.98682 1.000 35.39978 ? 397  ARG A C   1 
ATOM   3009 O O   . ARG A 1 378 ? -34.04398 13.92910  -16.63927 1.000 36.58391 ? 397  ARG A O   1 
ATOM   3010 C CB  . ARG A 1 378 ? -32.37784 11.47086  -18.07016 1.000 28.49328 ? 397  ARG A CB  1 
ATOM   3011 N N   . ILE A 1 379 ? -31.83095 14.07642  -16.25337 1.000 31.64277 ? 398  ILE A N   1 
ATOM   3012 C CA  . ILE A 1 379 ? -32.03150 14.82506  -15.00587 1.000 36.57069 ? 398  ILE A CA  1 
ATOM   3013 C C   . ILE A 1 379 ? -32.69661 16.17292  -15.27317 1.000 41.40294 ? 398  ILE A C   1 
ATOM   3014 O O   . ILE A 1 379 ? -33.61838 16.58001  -14.55409 1.000 43.06343 ? 398  ILE A O   1 
ATOM   3015 C CB  . ILE A 1 379 ? -30.70652 15.00883  -14.24329 1.000 33.73186 ? 398  ILE A CB  1 
ATOM   3016 C CG1 . ILE A 1 379 ? -30.16912 13.67669  -13.71979 1.000 33.21141 ? 398  ILE A CG1 1 
ATOM   3017 C CG2 . ILE A 1 379 ? -30.87517 16.01131  -13.09724 1.000 33.21855 ? 398  ILE A CG2 1 
ATOM   3018 C CD1 . ILE A 1 379 ? -28.72346 13.75066  -13.29335 1.000 27.65002 ? 398  ILE A CD1 1 
ATOM   3019 N N   . ILE A 1 380 ? -32.21510 16.90809  -16.27929 1.000 36.52332 ? 399  ILE A N   1 
ATOM   3020 C CA  . ILE A 1 380 ? -32.84642 18.18642  -16.60983 1.000 39.50793 ? 399  ILE A CA  1 
ATOM   3021 C C   . ILE A 1 380 ? -34.31289 17.98360  -16.98228 1.000 43.69674 ? 399  ILE A C   1 
ATOM   3022 O O   . ILE A 1 380 ? -35.18584 18.74291  -16.54328 1.000 47.74607 ? 399  ILE A O   1 
ATOM   3023 C CB  . ILE A 1 380 ? -32.05577 18.91780  -17.71591 1.000 36.96645 ? 399  ILE A CB  1 
ATOM   3024 C CG1 . ILE A 1 380 ? -30.61771 19.16274  -17.25650 1.000 33.21891 ? 399  ILE A CG1 1 
ATOM   3025 C CG2 . ILE A 1 380 ? -32.75080 20.21168  -18.13825 1.000 35.86254 ? 399  ILE A CG2 1 
ATOM   3026 C CD1 . ILE A 1 380 ? -29.61713 19.40076  -18.36753 1.000 29.30056 ? 399  ILE A CD1 1 
ATOM   3027 N N   . LEU A 1 381 ? -34.61017 16.94670  -17.77388 1.000 41.89439 ? 400  LEU A N   1 
ATOM   3028 C CA  . LEU A 1 381 ? -35.99779 16.60312  -18.07490 1.000 43.61111 ? 400  LEU A CA  1 
ATOM   3029 C C   . LEU A 1 381 ? -36.82031 16.39804  -16.80686 1.000 50.42537 ? 400  LEU A C   1 
ATOM   3030 O O   . LEU A 1 381 ? -37.95384 16.88606  -16.70951 1.000 49.90101 ? 400  LEU A O   1 
ATOM   3031 C CB  . LEU A 1 381 ? -36.06137 15.34710  -18.94835 1.000 42.60593 ? 400  LEU A CB  1 
ATOM   3032 C CG  . LEU A 1 381 ? -35.56143 15.38528  -20.39266 1.000 43.18037 ? 400  LEU A CG  1 
ATOM   3033 C CD1 . LEU A 1 381 ? -36.39141 14.44767  -21.24943 1.000 49.53153 ? 400  LEU A CD1 1 
ATOM   3034 C CD2 . LEU A 1 381 ? -35.68961 16.78914  -20.93096 1.000 44.74491 ? 400  LEU A CD2 1 
ATOM   3035 N N   . LYS A 1 382 ? -36.27053 15.68153  -15.82199 1.000 52.05453 ? 401  LYS A N   1 
ATOM   3036 C CA  . LYS A 1 382 ? -37.07704 15.28209  -14.67178 1.000 55.09167 ? 401  LYS A CA  1 
ATOM   3037 C C   . LYS A 1 382 ? -37.35698 16.44053  -13.72595 1.000 54.57247 ? 401  LYS A C   1 
ATOM   3038 O O   . LYS A 1 382 ? -38.27664 16.34354  -12.90620 1.000 60.81304 ? 401  LYS A O   1 
ATOM   3039 C CB  . LYS A 1 382 ? -36.39985 14.14389  -13.90903 1.000 47.80175 ? 401  LYS A CB  1 
ATOM   3040 C CG  . LYS A 1 382 ? -36.19257 12.90734  -14.76161 1.000 52.76341 ? 401  LYS A CG  1 
ATOM   3041 C CD  . LYS A 1 382 ? -37.48886 12.23020  -15.14875 1.000 58.49930 ? 401  LYS A CD  1 
ATOM   3042 C CE  . LYS A 1 382 ? -37.21000 11.02504  -16.04366 1.000 61.81709 ? 401  LYS A CE  1 
ATOM   3043 N NZ  . LYS A 1 382 ? -36.44436 9.95255   -15.35120 1.000 66.61708 ? 401  LYS A NZ  1 
ATOM   3044 N N   . LYS A 1 383 ? -36.59439 17.53101  -13.81912 1.000 56.84643 ? 402  LYS A N   1 
ATOM   3045 C CA  . LYS A 1 383 ? -36.86489 18.69234  -12.97835 1.000 59.60486 ? 402  LYS A CA  1 
ATOM   3046 C C   . LYS A 1 383 ? -37.98078 19.56734  -13.53814 1.000 63.69186 ? 402  LYS A C   1 
ATOM   3047 O O   . LYS A 1 383 ? -38.72861 20.17287  -12.76284 1.000 67.71884 ? 402  LYS A O   1 
ATOM   3048 C CB  . LYS A 1 383 ? -35.59354 19.51928  -12.78991 1.000 55.11201 ? 402  LYS A CB  1 
ATOM   3049 C CG  . LYS A 1 383 ? -34.42519 18.73825  -12.21943 1.000 56.52680 ? 402  LYS A CG  1 
ATOM   3050 C CD  . LYS A 1 383 ? -33.15409 19.57718  -12.20993 1.000 57.04744 ? 402  LYS A CD  1 
ATOM   3051 C CE  . LYS A 1 383 ? -32.18792 19.13368  -11.11189 1.000 59.47859 ? 402  LYS A CE  1 
ATOM   3052 N NZ  . LYS A 1 383 ? -32.88365 18.71444  -9.86261  1.000 54.70862 ? 402  LYS A NZ  1 
ATOM   3053 N N   . LYS A 1 384 ? -38.11434 19.64905  -14.86479 1.000 65.59031 ? 403  LYS A N   1 
ATOM   3054 C CA  . LYS A 1 384 ? -39.16974 20.47411  -15.44830 1.000 71.00266 ? 403  LYS A CA  1 
ATOM   3055 C C   . LYS A 1 384 ? -40.54262 19.83287  -15.26795 1.000 72.51806 ? 403  LYS A C   1 
ATOM   3056 O O   . LYS A 1 384 ? -41.49127 20.48846  -14.81700 1.000 72.84150 ? 403  LYS A O   1 
ATOM   3057 C CB  . LYS A 1 384 ? -38.88877 20.73011  -16.93109 1.000 71.84709 ? 403  LYS A CB  1 
ATOM   3058 C CG  . LYS A 1 384 ? -37.56555 21.42027  -17.22195 1.000 69.95343 ? 403  LYS A CG  1 
ATOM   3059 C CD  . LYS A 1 384 ? -37.79173 22.66728  -18.07237 1.000 73.86637 ? 403  LYS A CD  1 
ATOM   3060 C CE  . LYS A 1 384 ? -36.72593 22.81759  -19.15079 1.000 72.11455 ? 403  LYS A CE  1 
ATOM   3061 N NZ  . LYS A 1 384 ? -35.51665 23.54634  -18.65397 1.000 73.41946 ? 403  LYS A NZ  1 
ATOM   3062 N N   . LYS A 1 385 ? -40.66830 18.55432  -15.61773 1.000 68.53662 ? 404  LYS A N   1 
ATOM   3063 C CA  . LYS A 1 385 ? -41.95083 17.85963  -15.56060 1.000 69.69745 ? 404  LYS A CA  1 
ATOM   3064 C C   . LYS A 1 385 ? -42.42380 17.66022  -14.12155 1.000 72.40582 ? 404  LYS A C   1 
ATOM   3065 O O   . LYS A 1 385 ? -41.74632 18.05438  -13.17102 1.000 71.93712 ? 404  LYS A O   1 
ATOM   3066 C CB  . LYS A 1 385 ? -41.85628 16.50763  -16.27458 1.000 69.87286 ? 404  LYS A CB  1 
HETATM 3067 O O   . HOH B 2 .   ? 7.14607   10.11201  -2.66811  1.000 39.30579 ? 501  HOH A O   1 
HETATM 3068 O O   . HOH B 2 .   ? -41.61898 17.94465  -11.21607 1.000 55.27726 ? 502  HOH A O   1 
HETATM 3069 O O   . HOH B 2 .   ? -11.53350 8.95806   -25.39391 1.000 21.64456 ? 503  HOH A O   1 
HETATM 3070 O O   . HOH B 2 .   ? -39.08647 -37.86447 -14.89180 1.000 39.96812 ? 504  HOH A O   1 
HETATM 3071 O O   . HOH B 2 .   ? -20.80792 20.09396  0.38171   1.000 51.87743 ? 505  HOH A O   1 
HETATM 3072 O O   . HOH B 2 .   ? -22.88889 -25.69210 -20.60652 1.000 30.89139 ? 506  HOH A O   1 
HETATM 3073 O O   . HOH B 2 .   ? -17.10144 2.26379   -24.52373 1.000 32.36888 ? 507  HOH A O   1 
HETATM 3074 O O   . HOH B 2 .   ? -22.00001 -7.71438  -25.34598 1.000 36.56241 ? 508  HOH A O   1 
HETATM 3075 O O   . HOH B 2 .   ? -1.87421  12.85343  -26.57252 1.000 38.26338 ? 509  HOH A O   1 
HETATM 3076 O O   . HOH B 2 .   ? -32.98339 -6.94248  -16.38251 1.000 32.68694 ? 510  HOH A O   1 
HETATM 3077 O O   . HOH B 2 .   ? -32.05885 -11.25700 -6.31366  1.000 40.95021 ? 511  HOH A O   1 
HETATM 3078 O O   . HOH B 2 .   ? -4.50744  27.46684  -24.77692 1.000 33.82136 ? 512  HOH A O   1 
HETATM 3079 O O   . HOH B 2 .   ? -42.65469 -29.28769 -13.90365 1.000 34.77405 ? 513  HOH A O   1 
HETATM 3080 O O   . HOH B 2 .   ? -10.49818 5.89741   -16.11030 1.000 43.94434 ? 514  HOH A O   1 
HETATM 3081 O O   . HOH B 2 .   ? 7.42594   7.82899   -4.01519  1.000 39.45246 ? 515  HOH A O   1 
HETATM 3082 O O   . HOH B 2 .   ? 1.29299   19.45886  8.89780   1.000 38.05583 ? 516  HOH A O   1 
HETATM 3083 O O   . HOH B 2 .   ? -7.778    -5.139    -9.251    1.000 36.75261 ? 517  HOH A O   1 
HETATM 3084 O O   . HOH B 2 .   ? -23.91044 2.54713   -17.93147 1.000 23.87496 ? 518  HOH A O   1 
HETATM 3085 O O   . HOH B 2 .   ? -9.75194  9.32346   -22.36845 1.000 24.47002 ? 519  HOH A O   1 
HETATM 3086 O O   . HOH B 2 .   ? -10.30024 -5.44692  -6.75099  1.000 34.22918 ? 520  HOH A O   1 
HETATM 3087 O O   . HOH B 2 .   ? -28.228   15.252    -41.317   1.000 43.38869 ? 521  HOH A O   1 
HETATM 3088 O O   . HOH B 2 .   ? -36.144   -32.655   -32.852   1.000 39.71480 ? 522  HOH A O   1 
HETATM 3089 O O   . HOH B 2 .   ? -29.99377 12.90954  -2.88266  1.000 39.97048 ? 523  HOH A O   1 
HETATM 3090 O O   . HOH B 2 .   ? -9.34812  10.09851  -9.04886  1.000 35.22971 ? 524  HOH A O   1 
HETATM 3091 O O   . HOH B 2 .   ? -6.76957  17.57584  -38.29537 1.000 36.13539 ? 525  HOH A O   1 
HETATM 3092 O O   . HOH B 2 .   ? -12.60535 4.49683   -17.44675 1.000 44.05588 ? 526  HOH A O   1 
HETATM 3093 O O   . HOH B 2 .   ? -26.18057 7.85509   -0.48682  1.000 23.83214 ? 527  HOH A O   1 
HETATM 3094 O O   . HOH B 2 .   ? -18.97839 -14.90268 -7.10448  1.000 25.84217 ? 528  HOH A O   1 
HETATM 3095 O O   . HOH B 2 .   ? 15.21692  21.69119  -8.44604  1.000 32.71439 ? 529  HOH A O   1 
HETATM 3096 O O   . HOH B 2 .   ? -3.14875  17.77008  -15.90039 1.000 24.85169 ? 530  HOH A O   1 
HETATM 3097 O O   . HOH B 2 .   ? -8.41986  7.20800   -16.02815 1.000 41.78311 ? 531  HOH A O   1 
HETATM 3098 O O   . HOH B 2 .   ? -35.16725 -27.23508 -9.82664  1.000 23.53153 ? 532  HOH A O   1 
HETATM 3099 O O   . HOH B 2 .   ? -13.82085 2.03465   -23.48176 1.000 27.88349 ? 533  HOH A O   1 
HETATM 3100 O O   . HOH B 2 .   ? -19.48190 14.66205  -15.51477 1.000 26.04806 ? 534  HOH A O   1 
HETATM 3101 O O   . HOH B 2 .   ? -35.14120 -8.47198  -15.61471 1.000 43.51260 ? 535  HOH A O   1 
HETATM 3102 O O   . HOH B 2 .   ? -21.11181 -30.84083 -24.34763 1.000 26.64616 ? 536  HOH A O   1 
HETATM 3103 O O   . HOH B 2 .   ? -30.69283 -11.36608 -4.66910  1.000 37.70586 ? 537  HOH A O   1 
HETATM 3104 O O   . HOH B 2 .   ? -18.71061 -2.50571  -22.54726 1.000 32.78618 ? 538  HOH A O   1 
HETATM 3105 O O   . HOH B 2 .   ? -11.25135 0.77532   -6.04485  1.000 32.10255 ? 539  HOH A O   1 
HETATM 3106 O O   . HOH B 2 .   ? -29.56375 3.59923   -11.51344 1.000 37.95589 ? 540  HOH A O   1 
HETATM 3107 O O   . HOH B 2 .   ? -40.75752 -34.69584 -9.36951  1.000 37.29945 ? 541  HOH A O   1 
HETATM 3108 O O   . HOH B 2 .   ? 8.93195   22.29665  7.70422   1.000 27.92045 ? 542  HOH A O   1 
HETATM 3109 O O   . HOH B 2 .   ? -23.34651 -13.96253 -22.09668 1.000 16.75260 ? 543  HOH A O   1 
HETATM 3110 O O   . HOH B 2 .   ? -7.74328  23.12543  -15.33987 1.000 19.99382 ? 544  HOH A O   1 
HETATM 3111 O O   . HOH B 2 .   ? 9.71774   18.98000  7.19538   1.000 36.64885 ? 545  HOH A O   1 
HETATM 3112 O O   . HOH B 2 .   ? -5.46650  8.53580   -1.70377  1.000 32.42317 ? 546  HOH A O   1 
HETATM 3113 O O   . HOH B 2 .   ? -12.81679 17.58542  -2.85529  1.000 32.79842 ? 547  HOH A O   1 
HETATM 3114 O O   . HOH B 2 .   ? -37.09752 -29.14786 -31.99205 1.000 19.38652 ? 548  HOH A O   1 
HETATM 3115 O O   . HOH B 2 .   ? -24.94338 -38.06171 -9.01265  1.000 29.75739 ? 549  HOH A O   1 
HETATM 3116 O O   . HOH B 2 .   ? 8.32990   31.94178  3.03901   1.000 42.69576 ? 550  HOH A O   1 
HETATM 3117 O O   . HOH B 2 .   ? -23.25678 -36.39936 -3.71130  1.000 34.42394 ? 551  HOH A O   1 
HETATM 3118 O O   . HOH B 2 .   ? -10.92146 5.80007   -35.51090 1.000 33.76242 ? 552  HOH A O   1 
HETATM 3119 O O   . HOH B 2 .   ? -8.06775  25.08209  -17.17188 1.000 27.63466 ? 553  HOH A O   1 
HETATM 3120 O O   . HOH B 2 .   ? -25.45022 -7.18385  -25.39738 1.000 37.36592 ? 554  HOH A O   1 
HETATM 3121 O O   . HOH B 2 .   ? -26.11173 1.60466   -24.74425 1.000 38.68820 ? 555  HOH A O   1 
HETATM 3122 O O   . HOH B 2 .   ? -29.96944 -9.10258  -8.26460  1.000 22.83293 ? 556  HOH A O   1 
HETATM 3123 O O   . HOH B 2 .   ? -9.67207  3.81124   -14.19770 1.000 42.21458 ? 557  HOH A O   1 
HETATM 3124 O O   . HOH B 2 .   ? -24.56134 21.33611  -40.55046 1.000 34.74932 ? 558  HOH A O   1 
HETATM 3125 O O   . HOH B 2 .   ? -33.30893 -13.21025 -16.05803 1.000 33.56311 ? 559  HOH A O   1 
HETATM 3126 O O   . HOH B 2 .   ? 12.51084  8.98252   -2.33185  1.000 24.43087 ? 560  HOH A O   1 
HETATM 3127 O O   . HOH B 2 .   ? -16.65315 -12.87031 -27.05706 1.000 34.56914 ? 561  HOH A O   1 
HETATM 3128 O O   . HOH B 2 .   ? -16.52705 15.18966  10.35875  1.000 37.27151 ? 562  HOH A O   1 
HETATM 3129 O O   . HOH B 2 .   ? -19.51487 -9.80761  -25.01089 1.000 30.59261 ? 563  HOH A O   1 
HETATM 3130 O O   . HOH B 2 .   ? -32.91593 0.85326   -3.07009  1.000 33.37313 ? 564  HOH A O   1 
HETATM 3131 O O   . HOH B 2 .   ? -5.43214  19.84137  -27.75633 1.000 25.37031 ? 565  HOH A O   1 
HETATM 3132 O O   . HOH B 2 .   ? -11.46195 -13.46173 -15.22498 1.000 17.77235 ? 566  HOH A O   1 
HETATM 3133 O O   . HOH B 2 .   ? -25.04191 -0.34768  -24.64434 1.000 34.39519 ? 567  HOH A O   1 
HETATM 3134 O O   . HOH B 2 .   ? 11.44420  25.95000  -13.72865 1.000 29.00084 ? 568  HOH A O   1 
HETATM 3135 O O   . HOH B 2 .   ? -15.90094 4.68537   -28.90903 1.000 18.97947 ? 569  HOH A O   1 
HETATM 3136 O O   . HOH B 2 .   ? -12.33949 -5.11736  -10.40235 1.000 18.87450 ? 570  HOH A O   1 
HETATM 3137 O O   . HOH B 2 .   ? -13.22378 16.28468  -35.34543 1.000 18.40696 ? 571  HOH A O   1 
HETATM 3138 O O   . HOH B 2 .   ? 5.85709   11.11856  -16.20467 1.000 31.59616 ? 572  HOH A O   1 
HETATM 3139 O O   . HOH B 2 .   ? 5.45331   28.98566  12.26843  1.000 45.04044 ? 573  HOH A O   1 
HETATM 3140 O O   . HOH B 2 .   ? -3.61111  30.77960  -9.25387  1.000 33.07088 ? 574  HOH A O   1 
HETATM 3141 O O   . HOH B 2 .   ? -25.26266 16.77729  -2.64744  1.000 36.06567 ? 575  HOH A O   1 
HETATM 3142 O O   . HOH B 2 .   ? -2.19625  29.28848  -5.86085  1.000 28.59558 ? 576  HOH A O   1 
HETATM 3143 O O   . HOH B 2 .   ? -16.69997 -19.93441 -28.11666 1.000 35.08976 ? 577  HOH A O   1 
HETATM 3144 O O   . HOH B 2 .   ? -39.63152 -23.49939 -8.99717  1.000 37.10385 ? 578  HOH A O   1 
HETATM 3145 O O   . HOH B 2 .   ? 0.22275   10.57302  -10.92169 1.000 39.50786 ? 579  HOH A O   1 
HETATM 3146 O O   . HOH B 2 .   ? 13.48018  16.67707  -6.99711  1.000 18.04667 ? 580  HOH A O   1 
HETATM 3147 O O   . HOH B 2 .   ? -28.62889 7.04752   -13.61872 1.000 38.03864 ? 581  HOH A O   1 
HETATM 3148 O O   . HOH B 2 .   ? 4.35604   15.62018  -20.97819 1.000 45.16738 ? 582  HOH A O   1 
HETATM 3149 O O   . HOH B 2 .   ? -12.14781 17.28177  -13.94437 1.000 17.97165 ? 583  HOH A O   1 
HETATM 3150 O O   . HOH B 2 .   ? 4.90618   28.32927  -8.56658  1.000 21.18041 ? 584  HOH A O   1 
HETATM 3151 O O   . HOH B 2 .   ? -21.81713 2.29580   -28.61308 1.000 31.88787 ? 585  HOH A O   1 
HETATM 3152 O O   . HOH B 2 .   ? -17.05857 -17.42565 -15.65277 1.000 20.26679 ? 586  HOH A O   1 
HETATM 3153 O O   . HOH B 2 .   ? -28.39431 1.84875   -13.31610 1.000 34.02023 ? 587  HOH A O   1 
HETATM 3154 O O   . HOH B 2 .   ? 0.77375   17.92487  -21.60374 1.000 35.40452 ? 588  HOH A O   1 
HETATM 3155 O O   . HOH B 2 .   ? -33.33029 -16.29285 -23.22402 1.000 24.06647 ? 589  HOH A O   1 
HETATM 3156 O O   . HOH B 2 .   ? -22.04916 -12.77394 -13.55263 1.000 13.61680 ? 590  HOH A O   1 
HETATM 3157 O O   . HOH B 2 .   ? -25.64097 -8.76159  1.90406   1.000 30.12071 ? 591  HOH A O   1 
HETATM 3158 O O   . HOH B 2 .   ? -22.84954 -9.38573  3.17451   1.000 36.16383 ? 592  HOH A O   1 
HETATM 3159 O O   . HOH B 2 .   ? -11.92624 13.23502  -15.84574 1.000 18.04897 ? 593  HOH A O   1 
HETATM 3160 O O   . HOH B 2 .   ? -31.56060 29.14394  -28.52001 1.000 24.58934 ? 594  HOH A O   1 
HETATM 3161 O O   . HOH B 2 .   ? -24.30041 -19.32791 -5.85900  1.000 36.05317 ? 595  HOH A O   1 
HETATM 3162 O O   . HOH B 2 .   ? -11.35481 29.87206  -21.79560 1.000 40.50170 ? 596  HOH A O   1 
HETATM 3163 O O   . HOH B 2 .   ? -19.60731 16.66114  -13.89307 1.000 30.64158 ? 597  HOH A O   1 
HETATM 3164 O O   . HOH B 2 .   ? -26.28411 24.68329  -20.11556 1.000 32.75307 ? 598  HOH A O   1 
HETATM 3165 O O   . HOH B 2 .   ? -19.76863 8.63837   -34.41624 1.000 17.69467 ? 599  HOH A O   1 
HETATM 3166 O O   . HOH B 2 .   ? -30.66258 -3.00125  -17.34111 1.000 26.59609 ? 600  HOH A O   1 
HETATM 3167 O O   . HOH B 2 .   ? 2.80771   11.28733  -11.20737 1.000 24.08910 ? 601  HOH A O   1 
HETATM 3168 O O   . HOH B 2 .   ? -39.95119 -35.03620 -30.87170 1.000 35.20006 ? 602  HOH A O   1 
HETATM 3169 O O   . HOH B 2 .   ? -29.07964 -9.75792  -1.93564  1.000 21.39615 ? 603  HOH A O   1 
HETATM 3170 O O   . HOH B 2 .   ? -24.51697 -19.45628 -9.91849  1.000 22.36030 ? 604  HOH A O   1 
HETATM 3171 O O   . HOH B 2 .   ? -13.24504 17.27627  -5.48950  1.000 31.01556 ? 605  HOH A O   1 
HETATM 3172 O O   . HOH B 2 .   ? 13.69058  22.77702  -10.84748 1.000 20.89243 ? 606  HOH A O   1 
HETATM 3173 O O   . HOH B 2 .   ? -0.70429  15.39536  0.82386   1.000 18.97984 ? 607  HOH A O   1 
HETATM 3174 O O   . HOH B 2 .   ? -21.21956 -0.87847  -24.10269 1.000 23.12727 ? 608  HOH A O   1 
HETATM 3175 O O   . HOH B 2 .   ? -0.87762  18.62136  -5.90416  1.000 15.34228 ? 609  HOH A O   1 
HETATM 3176 O O   . HOH B 2 .   ? -9.91127  29.17201  6.05391   1.000 41.77792 ? 610  HOH A O   1 
HETATM 3177 O O   . HOH B 2 .   ? -3.96893  16.72812  -13.61946 1.000 20.54966 ? 611  HOH A O   1 
HETATM 3178 O O   . HOH B 2 .   ? -12.99540 -10.95464 -14.33152 1.000 15.74497 ? 612  HOH A O   1 
HETATM 3179 O O   . HOH B 2 .   ? -19.87639 13.53390  -5.33866  1.000 25.06967 ? 613  HOH A O   1 
HETATM 3180 O O   . HOH B 2 .   ? -9.12083  9.70862   -3.59994  1.000 31.29652 ? 614  HOH A O   1 
HETATM 3181 O O   . HOH B 2 .   ? -12.30707 21.05196  -36.65541 1.000 42.11341 ? 615  HOH A O   1 
HETATM 3182 O O   . HOH B 2 .   ? -33.07945 -21.29940 -15.93076 1.000 15.78727 ? 616  HOH A O   1 
HETATM 3183 O O   . HOH B 2 .   ? -30.35987 16.78890  -37.75485 1.000 28.77360 ? 617  HOH A O   1 
HETATM 3184 O O   . HOH B 2 .   ? -15.664   0.837     8.362     1.000 37.66056 ? 618  HOH A O   1 
HETATM 3185 O O   . HOH B 2 .   ? -14.32466 -3.32583  -18.61225 1.000 32.09573 ? 619  HOH A O   1 
HETATM 3186 O O   . HOH B 2 .   ? -19.18152 2.01362   -14.65465 1.000 18.12795 ? 620  HOH A O   1 
HETATM 3187 O O   . HOH B 2 .   ? -16.92663 9.05920   -5.70890  1.000 26.52264 ? 621  HOH A O   1 
HETATM 3188 O O   . HOH B 2 .   ? -30.48633 -3.36810  -20.47097 1.000 35.56238 ? 622  HOH A O   1 
HETATM 3189 O O   . HOH B 2 .   ? 0.29036   27.53673  -4.45455  1.000 29.21700 ? 623  HOH A O   1 
HETATM 3190 O O   . HOH B 2 .   ? -22.99213 -31.12192 -29.40473 1.000 29.84330 ? 624  HOH A O   1 
HETATM 3191 O O   . HOH B 2 .   ? -2.93688  17.80055  -28.92059 1.000 35.35489 ? 625  HOH A O   1 
HETATM 3192 O O   . HOH B 2 .   ? -32.64046 -27.62526 -30.42803 1.000 19.04068 ? 626  HOH A O   1 
HETATM 3193 O O   . HOH B 2 .   ? -29.54237 -9.80849  -18.29853 1.000 24.22128 ? 627  HOH A O   1 
HETATM 3194 O O   . HOH B 2 .   ? -3.40250  21.62424  -28.57925 1.000 44.01764 ? 628  HOH A O   1 
HETATM 3195 O O   . HOH B 2 .   ? -25.95566 22.09404  -11.81408 1.000 43.23657 ? 629  HOH A O   1 
HETATM 3196 O O   . HOH B 2 .   ? -17.28647 -18.00677 -29.06678 1.000 47.67716 ? 630  HOH A O   1 
HETATM 3197 O O   . HOH B 2 .   ? -8.28163  30.14440  -10.40208 1.000 37.86191 ? 631  HOH A O   1 
HETATM 3198 O O   . HOH B 2 .   ? -26.00913 -11.62174 -16.03643 1.000 10.85989 ? 632  HOH A O   1 
HETATM 3199 O O   . HOH B 2 .   ? -39.09778 -26.68652 -12.00856 1.000 25.01632 ? 633  HOH A O   1 
HETATM 3200 O O   . HOH B 2 .   ? -24.77044 -8.20463  -14.64168 1.000 14.21294 ? 634  HOH A O   1 
HETATM 3201 O O   . HOH B 2 .   ? -16.87921 -10.01431 1.90788   1.000 29.51422 ? 635  HOH A O   1 
HETATM 3202 O O   . HOH B 2 .   ? -30.94655 11.33021  -6.63010  1.000 31.70218 ? 636  HOH A O   1 
HETATM 3203 O O   . HOH B 2 .   ? -32.079   24.426    -27.818   1.000 25.82449 ? 637  HOH A O   1 
HETATM 3204 O O   . HOH B 2 .   ? -19.69240 6.61392   -10.18991 1.000 26.54956 ? 638  HOH A O   1 
HETATM 3205 O O   . HOH B 2 .   ? -16.82323 7.36418   0.73929   1.000 19.47354 ? 639  HOH A O   1 
HETATM 3206 O O   . HOH B 2 .   ? -19.07527 16.48723  11.23439  1.000 33.13377 ? 640  HOH A O   1 
HETATM 3207 O O   . HOH B 2 .   ? -26.49674 4.46413   -12.02073 1.000 30.68150 ? 641  HOH A O   1 
HETATM 3208 O O   . HOH B 2 .   ? -19.62065 4.67129   -13.90236 1.000 30.65314 ? 642  HOH A O   1 
HETATM 3209 O O   . HOH B 2 .   ? -34.02917 -6.58148  -2.57816  1.000 51.56978 ? 643  HOH A O   1 
HETATM 3210 O O   . HOH B 2 .   ? -28.16379 19.33234  -38.24921 1.000 26.80258 ? 644  HOH A O   1 
HETATM 3211 O O   . HOH B 2 .   ? -14.47377 1.08901   -28.04535 1.000 27.98635 ? 645  HOH A O   1 
HETATM 3212 O O   . HOH B 2 .   ? -11.71179 1.77118   -9.91210  1.000 32.61999 ? 646  HOH A O   1 
HETATM 3213 O O   . HOH B 2 .   ? -16.36886 4.59257   -3.70344  1.000 21.20617 ? 647  HOH A O   1 
HETATM 3214 O O   . HOH B 2 .   ? 20.34898  24.03162  1.61286   1.000 36.75709 ? 648  HOH A O   1 
HETATM 3215 O O   . HOH B 2 .   ? -3.93672  11.46515  -37.48437 1.000 36.37957 ? 649  HOH A O   1 
HETATM 3216 O O   . HOH B 2 .   ? -31.24955 -39.55382 -26.26523 1.000 25.58303 ? 650  HOH A O   1 
HETATM 3217 O O   . HOH B 2 .   ? -2.54505  28.45773  -15.67342 1.000 38.71444 ? 651  HOH A O   1 
HETATM 3218 O O   . HOH B 2 .   ? -28.74798 22.97002  -20.11243 1.000 41.41028 ? 652  HOH A O   1 
HETATM 3219 O O   . HOH B 2 .   ? -25.16988 29.48496  -32.80256 1.000 32.37899 ? 653  HOH A O   1 
HETATM 3220 O O   . HOH B 2 .   ? -18.11033 -10.54189 -10.36633 1.000 12.86318 ? 654  HOH A O   1 
HETATM 3221 O O   . HOH B 2 .   ? -19.93641 -18.05745 -18.65866 1.000 19.52809 ? 655  HOH A O   1 
HETATM 3222 O O   . HOH B 2 .   ? 0.20668   18.97563  -8.58961  1.000 15.21720 ? 656  HOH A O   1 
HETATM 3223 O O   . HOH B 2 .   ? -11.12295 5.21284   -32.67724 1.000 26.05809 ? 657  HOH A O   1 
HETATM 3224 O O   . HOH B 2 .   ? 3.42304   27.52123  -11.08996 1.000 19.91552 ? 658  HOH A O   1 
HETATM 3225 O O   . HOH B 2 .   ? -42.59189 -28.58346 -20.94915 1.000 20.41897 ? 659  HOH A O   1 
HETATM 3226 O O   . HOH B 2 .   ? -33.02930 -15.14095 -26.00509 1.000 29.77649 ? 660  HOH A O   1 
HETATM 3227 O O   . HOH B 2 .   ? -40.80071 -26.98455 -30.52545 1.000 31.85374 ? 661  HOH A O   1 
HETATM 3228 O O   . HOH B 2 .   ? -31.97611 -33.64116 -31.74899 1.000 27.66989 ? 662  HOH A O   1 
HETATM 3229 O O   . HOH B 2 .   ? -11.11601 23.13869  -38.06465 1.000 42.11519 ? 663  HOH A O   1 
HETATM 3230 O O   . HOH B 2 .   ? 13.95204  13.16857  -0.36502  1.000 18.05153 ? 664  HOH A O   1 
HETATM 3231 O O   . HOH B 2 .   ? -27.528   -25.210   -33.251   1.000 26.36189 ? 665  HOH A O   1 
HETATM 3232 O O   . HOH B 2 .   ? -45.67415 -28.14461 -18.93989 1.000 43.99887 ? 666  HOH A O   1 
HETATM 3233 O O   . HOH B 2 .   ? 8.65079   12.24328  -16.85004 1.000 33.89261 ? 667  HOH A O   1 
HETATM 3234 O O   . HOH B 2 .   ? -1.27634  11.81326  -13.92568 1.000 26.31813 ? 668  HOH A O   1 
HETATM 3235 O O   . HOH B 2 .   ? -8.39565  5.57930   -25.19170 1.000 38.77343 ? 669  HOH A O   1 
HETATM 3236 O O   . HOH B 2 .   ? 21.31759  20.99713  3.63384   1.000 39.71529 ? 670  HOH A O   1 
HETATM 3237 O O   . HOH B 2 .   ? -19.58287 -31.54769 -20.37426 1.000 35.68402 ? 671  HOH A O   1 
HETATM 3238 O O   . HOH B 2 .   ? -38.11654 -37.31673 -27.61117 1.000 42.04061 ? 672  HOH A O   1 
HETATM 3239 O O   . HOH B 2 .   ? -6.61355  28.99750  -2.98897  1.000 21.19521 ? 673  HOH A O   1 
HETATM 3240 O O   . HOH B 2 .   ? 0.17985   23.54774  -19.29837 1.000 19.62810 ? 674  HOH A O   1 
HETATM 3241 O O   . HOH B 2 .   ? -29.67795 -13.39430 -18.89460 1.000 23.38389 ? 675  HOH A O   1 
HETATM 3242 O O   . HOH B 2 .   ? -22.79317 -38.36295 -19.22823 1.000 40.90003 ? 676  HOH A O   1 
HETATM 3243 O O   . HOH B 2 .   ? -17.43770 20.71393  -36.29862 1.000 40.98043 ? 677  HOH A O   1 
HETATM 3244 O O   . HOH B 2 .   ? -9.83991  6.91382   -27.06992 1.000 25.49767 ? 678  HOH A O   1 
HETATM 3245 O O   . HOH B 2 .   ? 9.47783   19.82087  -21.90387 1.000 35.22654 ? 679  HOH A O   1 
HETATM 3246 O O   . HOH B 2 .   ? -8.53310  4.99579   -21.05207 1.000 49.82279 ? 680  HOH A O   1 
HETATM 3247 O O   . HOH B 2 .   ? -33.65336 -32.06416 -0.97045  1.000 17.03708 ? 681  HOH A O   1 
HETATM 3248 O O   . HOH B 2 .   ? -26.90407 1.03340   -21.45930 1.000 28.41305 ? 682  HOH A O   1 
HETATM 3249 O O   . HOH B 2 .   ? -1.74568  16.48004  -33.95005 1.000 37.35268 ? 683  HOH A O   1 
HETATM 3250 O O   . HOH B 2 .   ? -29.99902 -38.99504 -23.95584 1.000 25.83123 ? 684  HOH A O   1 
HETATM 3251 O O   . HOH B 2 .   ? -11.62335 -18.74785 -23.07042 1.000 37.62940 ? 685  HOH A O   1 
HETATM 3252 O O   . HOH B 2 .   ? -26.53577 -26.19858 -2.20194  1.000 32.58505 ? 686  HOH A O   1 
HETATM 3253 O O   . HOH B 2 .   ? -27.37659 7.34279   -19.25578 1.000 28.73597 ? 687  HOH A O   1 
HETATM 3254 O O   . HOH B 2 .   ? -23.80670 -16.13076 -26.13481 1.000 28.71508 ? 688  HOH A O   1 
HETATM 3255 O O   . HOH B 2 .   ? -10.56749 12.63412  6.93695   1.000 29.13379 ? 689  HOH A O   1 
HETATM 3256 O O   . HOH B 2 .   ? -24.78021 -33.10301 -32.21776 1.000 27.90467 ? 690  HOH A O   1 
HETATM 3257 O O   . HOH B 2 .   ? -27.560   29.812    -35.981   1.000 35.18613 ? 691  HOH A O   1 
HETATM 3258 O O   . HOH B 2 .   ? -11.85143 -3.46884  -19.39580 1.000 38.59119 ? 692  HOH A O   1 
HETATM 3259 O O   . HOH B 2 .   ? -33.33325 -25.69911 -32.28345 1.000 16.65182 ? 693  HOH A O   1 
HETATM 3260 O O   . HOH B 2 .   ? -24.32561 20.55531  -35.90954 1.000 24.40540 ? 694  HOH A O   1 
HETATM 3261 O O   . HOH B 2 .   ? -36.94150 -21.00516 -4.13819  1.000 23.87836 ? 695  HOH A O   1 
HETATM 3262 O O   . HOH B 2 .   ? -11.70967 16.93271  -8.01302  1.000 24.26655 ? 696  HOH A O   1 
HETATM 3263 O O   . HOH B 2 .   ? 1.70754   9.28992   -5.19506  1.000 27.22776 ? 697  HOH A O   1 
HETATM 3264 O O   . HOH B 2 .   ? -18.68211 22.73613  -14.35355 1.000 40.92829 ? 698  HOH A O   1 
HETATM 3265 O O   . HOH B 2 .   ? -23.41329 -12.64366 1.33596   1.000 49.62495 ? 699  HOH A O   1 
HETATM 3266 O O   . HOH B 2 .   ? 1.59678   29.31079  -2.84103  1.000 27.98532 ? 700  HOH A O   1 
HETATM 3267 O O   . HOH B 2 .   ? -13.63365 4.07148   6.15255   1.000 39.96481 ? 701  HOH A O   1 
HETATM 3268 O O   . HOH B 2 .   ? -42.84834 -25.72539 -25.95831 1.000 30.08362 ? 702  HOH A O   1 
HETATM 3269 O O   . HOH B 2 .   ? -27.41352 11.06695  -10.03433 1.000 27.46917 ? 703  HOH A O   1 
HETATM 3270 O O   . HOH B 2 .   ? -12.95885 -21.24789 -20.51288 1.000 33.03781 ? 704  HOH A O   1 
HETATM 3271 O O   . HOH B 2 .   ? -38.10330 -23.49351 -4.25496  1.000 19.71991 ? 705  HOH A O   1 
HETATM 3272 O O   . HOH B 2 .   ? -19.30300 11.32515  -11.62796 1.000 25.67441 ? 706  HOH A O   1 
HETATM 3273 O O   . HOH B 2 .   ? -12.53732 17.70653  -10.47015 1.000 24.85954 ? 707  HOH A O   1 
HETATM 3274 O O   . HOH B 2 .   ? -16.21509 23.74205  -12.53305 1.000 43.10602 ? 708  HOH A O   1 
HETATM 3275 O O   . HOH B 2 .   ? -19.25134 19.46417  8.77757   1.000 48.51824 ? 709  HOH A O   1 
HETATM 3276 O O   . HOH B 2 .   ? -24.46471 26.39422  -26.38309 1.000 31.32276 ? 710  HOH A O   1 
HETATM 3277 O O   . HOH B 2 .   ? -17.52838 -10.89815 -7.01161  1.000 16.88681 ? 711  HOH A O   1 
HETATM 3278 O O   . HOH B 2 .   ? 20.67207  19.70410  -3.82100  1.000 28.72759 ? 712  HOH A O   1 
HETATM 3279 O O   . HOH B 2 .   ? 18.33715  17.21172  -2.04397  1.000 24.86473 ? 713  HOH A O   1 
HETATM 3280 O O   . HOH B 2 .   ? 6.58996   28.17818  3.45409   1.000 21.53937 ? 714  HOH A O   1 
HETATM 3281 O O   . HOH B 2 .   ? -39.67931 -17.38120 -18.51622 1.000 26.53639 ? 715  HOH A O   1 
HETATM 3282 O O   . HOH B 2 .   ? -27.50761 -7.80840  -22.25180 1.000 33.17299 ? 716  HOH A O   1 
HETATM 3283 O O   . HOH B 2 .   ? 1.36486   33.48969  2.57548   1.000 32.96725 ? 717  HOH A O   1 
HETATM 3284 O O   . HOH B 2 .   ? -8.50477  0.69247   -10.09134 1.000 41.91199 ? 718  HOH A O   1 
HETATM 3285 O O   . HOH B 2 .   ? -17.39952 14.14303  -4.69713  1.000 39.52517 ? 719  HOH A O   1 
HETATM 3286 O O   . HOH B 2 .   ? 7.15785   21.78513  -20.61693 1.000 35.22793 ? 720  HOH A O   1 
HETATM 3287 O O   . HOH B 2 .   ? -19.66720 -13.51088 -14.75451 1.000 15.14340 ? 721  HOH A O   1 
HETATM 3288 O O   . HOH B 2 .   ? -36.33534 -48.08331 -29.20555 1.000 44.28406 ? 722  HOH A O   1 
HETATM 3289 O O   . HOH B 2 .   ? -12.56917 0.45852   -31.39768 1.000 42.21639 ? 723  HOH A O   1 
HETATM 3290 O O   . HOH B 2 .   ? 15.25135  27.30144  6.05057   1.000 42.18126 ? 724  HOH A O   1 
HETATM 3291 O O   . HOH B 2 .   ? -30.54081 -19.10878 -6.12169  1.000 14.37366 ? 725  HOH A O   1 
HETATM 3292 O O   . HOH B 2 .   ? -12.98211 28.48154  -5.13381  1.000 29.62909 ? 726  HOH A O   1 
HETATM 3293 O O   . HOH B 2 .   ? -36.52843 -17.50649 -16.20321 1.000 28.08460 ? 727  HOH A O   1 
HETATM 3294 O O   . HOH B 2 .   ? -10.51790 11.41127  -6.02366  1.000 32.29979 ? 728  HOH A O   1 
HETATM 3295 O O   . HOH B 2 .   ? -24.73266 -12.18633 -20.55504 1.000 14.56973 ? 729  HOH A O   1 
HETATM 3296 O O   . HOH B 2 .   ? -39.81899 -16.24595 -21.37759 1.000 40.25517 ? 730  HOH A O   1 
HETATM 3297 O O   . HOH B 2 .   ? -32.71791 -0.58030  -4.92586  1.000 23.12254 ? 731  HOH A O   1 
HETATM 3298 O O   . HOH B 2 .   ? -19.96957 12.99439  -1.14579  1.000 28.06187 ? 732  HOH A O   1 
HETATM 3299 O O   . HOH B 2 .   ? -10.52417 27.83648  -15.08580 1.000 35.16260 ? 733  HOH A O   1 
HETATM 3300 O O   . HOH B 2 .   ? -35.60698 -43.36981 -23.55431 1.000 36.60225 ? 734  HOH A O   1 
HETATM 3301 O O   . HOH B 2 .   ? -2.63973  15.62136  6.03121   1.000 39.68927 ? 735  HOH A O   1 
HETATM 3302 O O   . HOH B 2 .   ? -41.85801 -32.42769 -22.59692 1.000 38.40810 ? 736  HOH A O   1 
HETATM 3303 O O   . HOH B 2 .   ? -27.86879 17.63491  -15.70170 1.000 29.19793 ? 737  HOH A O   1 
HETATM 3304 O O   . HOH B 2 .   ? -17.75498 28.50831  -26.32634 1.000 26.38558 ? 738  HOH A O   1 
HETATM 3305 O O   . HOH B 2 .   ? -20.86753 7.05621   -18.84171 1.000 24.57693 ? 739  HOH A O   1 
HETATM 3306 O O   . HOH B 2 .   ? -10.21122 0.05996   0.83094   1.000 34.82182 ? 740  HOH A O   1 
HETATM 3307 O O   . HOH B 2 .   ? -10.04596 28.26821  -19.69890 1.000 29.94804 ? 741  HOH A O   1 
HETATM 3308 O O   . HOH B 2 .   ? 12.41019  28.15064  -6.24225  1.000 34.32163 ? 742  HOH A O   1 
HETATM 3309 O O   . HOH B 2 .   ? -11.42696 11.50689  0.24075   1.000 27.19739 ? 743  HOH A O   1 
HETATM 3310 O O   . HOH B 2 .   ? -21.67086 22.35349  -15.06795 1.000 40.58726 ? 744  HOH A O   1 
HETATM 3311 O O   . HOH B 2 .   ? -31.25867 6.00151   1.00117   1.000 35.50629 ? 745  HOH A O   1 
HETATM 3312 O O   . HOH B 2 .   ? -16.91560 -13.47659 -0.45318  1.000 21.37622 ? 746  HOH A O   1 
HETATM 3313 O O   . HOH B 2 .   ? -38.53508 -34.19742 -21.91043 1.000 26.42692 ? 747  HOH A O   1 
HETATM 3314 O O   . HOH B 2 .   ? -21.07022 28.71647  -25.20081 1.000 36.54434 ? 748  HOH A O   1 
HETATM 3315 O O   . HOH B 2 .   ? -36.60500 -13.16748 -24.14698 1.000 41.73227 ? 749  HOH A O   1 
HETATM 3316 O O   . HOH B 2 .   ? -2.97934  27.60609  -19.56179 1.000 36.82662 ? 750  HOH A O   1 
HETATM 3317 O O   . HOH B 2 .   ? -9.42215  18.39359  -8.14674  1.000 17.33546 ? 751  HOH A O   1 
HETATM 3318 O O   . HOH B 2 .   ? -34.23717 -28.85859 -5.62106  1.000 19.54162 ? 752  HOH A O   1 
HETATM 3319 O O   . HOH B 2 .   ? -29.95977 -0.09674  -17.31532 1.000 24.72550 ? 753  HOH A O   1 
HETATM 3320 O O   . HOH B 2 .   ? 9.17803   13.45914  -1.95421  1.000 22.34756 ? 754  HOH A O   1 
HETATM 3321 O O   . HOH B 2 .   ? 3.82154   9.46117   -12.49106 1.000 42.81582 ? 755  HOH A O   1 
HETATM 3322 O O   . HOH B 2 .   ? -31.21397 -15.86907 -22.22921 1.000 26.18457 ? 756  HOH A O   1 
HETATM 3323 O O   . HOH B 2 .   ? -25.304   5.961     -30.511   1.000 25.37417 ? 757  HOH A O   1 
HETATM 3324 O O   . HOH B 2 .   ? -18.26956 25.48784  -33.78101 1.000 38.76969 ? 758  HOH A O   1 
HETATM 3325 O O   . HOH B 2 .   ? -13.88677 5.41363   2.55633   1.000 37.85768 ? 759  HOH A O   1 
HETATM 3326 O O   . HOH B 2 .   ? -10.95170 9.44028   -19.72744 1.000 29.94123 ? 760  HOH A O   1 
HETATM 3327 O O   . HOH B 2 .   ? 2.26282   24.35649  8.52322   1.000 28.40742 ? 761  HOH A O   1 
HETATM 3328 O O   . HOH B 2 .   ? 1.14411   26.56418  -17.37651 1.000 20.05371 ? 762  HOH A O   1 
HETATM 3329 O O   . HOH B 2 .   ? -26.78045 13.00371  -40.88670 1.000 28.71745 ? 763  HOH A O   1 
HETATM 3330 O O   . HOH B 2 .   ? -12.66328 12.63530  -36.28989 1.000 27.39438 ? 764  HOH A O   1 
HETATM 3331 O O   . HOH B 2 .   ? -21.975   -32.075   -7.483    1.000 39.46151 ? 765  HOH A O   1 
HETATM 3332 O O   . HOH B 2 .   ? -20.14651 -18.48778 -15.87041 1.000 19.87511 ? 766  HOH A O   1 
HETATM 3333 O O   . HOH B 2 .   ? -25.43155 -26.53986 -8.73758  1.000 28.72417 ? 767  HOH A O   1 
HETATM 3334 O O   . HOH B 2 .   ? -13.224   -19.340   -16.628   1.000 15.78936 ? 768  HOH A O   1 
HETATM 3335 O O   . HOH B 2 .   ? -16.00496 10.19963  -37.62029 1.000 21.21156 ? 769  HOH A O   1 
HETATM 3336 O O   . HOH B 2 .   ? -34.00328 -15.25423 -12.37895 1.000 30.07385 ? 770  HOH A O   1 
HETATM 3337 O O   . HOH B 2 .   ? -14.90382 3.33188   -1.32922  1.000 25.78083 ? 771  HOH A O   1 
HETATM 3338 O O   . HOH B 2 .   ? -25.376   -29.990   -5.427    1.000 33.35227 ? 772  HOH A O   1 
HETATM 3339 O O   . HOH B 2 .   ? -44.03322 -20.06056 -21.35248 1.000 33.54476 ? 773  HOH A O   1 
HETATM 3340 O O   . HOH B 2 .   ? -23.19338 -11.09450 -15.32457 1.000 12.16279 ? 774  HOH A O   1 
HETATM 3341 O O   . HOH B 2 .   ? -4.78964  14.61188  -17.41903 1.000 31.92532 ? 775  HOH A O   1 
HETATM 3342 O O   . HOH B 2 .   ? -37.31431 -40.09915 -22.57506 1.000 39.67789 ? 776  HOH A O   1 
HETATM 3343 O O   . HOH B 2 .   ? -22.85358 13.04513  -11.76105 1.000 25.56283 ? 777  HOH A O   1 
HETATM 3344 O O   . HOH B 2 .   ? -34.33490 -11.10149 -9.73083  1.000 35.98917 ? 778  HOH A O   1 
HETATM 3345 O O   . HOH B 2 .   ? -4.81083  27.40501  -18.62646 1.000 35.97921 ? 779  HOH A O   1 
HETATM 3346 O O   . HOH B 2 .   ? -15.63072 22.98347  -33.06133 1.000 37.70879 ? 780  HOH A O   1 
HETATM 3347 O O   . HOH B 2 .   ? -17.67405 7.03891   -3.74698  1.000 18.23526 ? 781  HOH A O   1 
HETATM 3348 O O   . HOH B 2 .   ? -4.12802  7.84723   -13.63639 1.000 40.77831 ? 782  HOH A O   1 
HETATM 3349 O O   . HOH B 2 .   ? -36.45319 -37.39493 -15.15183 1.000 28.49509 ? 783  HOH A O   1 
HETATM 3350 O O   . HOH B 2 .   ? -1.64110  24.16694  -27.15542 1.000 34.77398 ? 784  HOH A O   1 
HETATM 3351 O O   . HOH B 2 .   ? -32.62691 -5.81856  -9.00281  1.000 25.85210 ? 785  HOH A O   1 
HETATM 3352 O O   . HOH B 2 .   ? -25.40116 8.14419   -17.17318 1.000 35.99710 ? 786  HOH A O   1 
HETATM 3353 O O   . HOH B 2 .   ? -17.50262 3.30915   -26.99902 1.000 17.85893 ? 787  HOH A O   1 
HETATM 3354 O O   . HOH B 2 .   ? -31.47911 10.31194  -35.45544 1.000 41.80154 ? 788  HOH A O   1 
HETATM 3355 O O   . HOH B 2 .   ? -29.90409 26.45666  -21.78162 1.000 27.83653 ? 789  HOH A O   1 
HETATM 3356 O O   . HOH B 2 .   ? -37.64422 -45.13475 -26.02505 1.000 38.34987 ? 790  HOH A O   1 
HETATM 3357 O O   . HOH B 2 .   ? 1.40917   21.75313  7.62408   1.000 30.26547 ? 791  HOH A O   1 
HETATM 3358 O O   . HOH B 2 .   ? 5.84066   17.01979  -22.59123 1.000 40.50713 ? 792  HOH A O   1 
HETATM 3359 O O   . HOH B 2 .   ? -19.77278 -9.84021  3.33137   1.000 22.35401 ? 793  HOH A O   1 
HETATM 3360 O O   . HOH B 2 .   ? -2.57406  29.51413  8.69760   1.000 31.31736 ? 794  HOH A O   1 
HETATM 3361 O O   . HOH B 2 .   ? -36.987   -35.563   -7.172    1.000 28.92519 ? 795  HOH A O   1 
HETATM 3362 O O   . HOH B 2 .   ? -42.14182 -21.02143 -24.85593 1.000 34.72255 ? 796  HOH A O   1 
HETATM 3363 O O   . HOH B 2 .   ? -3.75721  14.41335  4.09337   1.000 34.93227 ? 797  HOH A O   1 
HETATM 3364 O O   . HOH B 2 .   ? -41.20643 -28.18441 -11.00508 1.000 36.89262 ? 798  HOH A O   1 
HETATM 3365 O O   . HOH B 2 .   ? -25.28643 -36.93958 -25.82955 1.000 28.86771 ? 799  HOH A O   1 
HETATM 3366 O O   . HOH B 2 .   ? -9.666    -10.891   -8.790    1.000 17.83637 ? 800  HOH A O   1 
HETATM 3367 O O   . HOH B 2 .   ? -25.43205 -24.84757 -28.52607 1.000 36.63730 ? 801  HOH A O   1 
HETATM 3368 O O   . HOH B 2 .   ? -4.17289  16.09043  -19.40667 1.000 36.69447 ? 802  HOH A O   1 
HETATM 3369 O O   . HOH B 2 .   ? -2.02140  17.88725  -36.60620 1.000 39.03219 ? 803  HOH A O   1 
HETATM 3370 O O   . HOH B 2 .   ? -0.52117  23.19826  11.07825  1.000 31.74411 ? 804  HOH A O   1 
HETATM 3371 O O   . HOH B 2 .   ? -23.94712 -20.03245 -24.78735 1.000 30.05778 ? 805  HOH A O   1 
HETATM 3372 O O   . HOH B 2 .   ? -23.00269 -25.34022 -23.94441 1.000 31.62317 ? 806  HOH A O   1 
HETATM 3373 O O   . HOH B 2 .   ? -28.09446 17.65305  -40.67426 1.000 38.54947 ? 807  HOH A O   1 
HETATM 3374 O O   . HOH B 2 .   ? -5.60415  22.82993  -33.06476 1.000 40.25584 ? 808  HOH A O   1 
HETATM 3375 O O   . HOH B 2 .   ? -11.87791 -15.36323 -18.56005 1.000 40.31442 ? 809  HOH A O   1 
HETATM 3376 O O   . HOH B 2 .   ? -29.30357 -32.52503 -32.22119 1.000 24.56953 ? 810  HOH A O   1 
HETATM 3377 O O   . HOH B 2 .   ? -41.87511 23.30832  -15.46509 1.000 56.58023 ? 811  HOH A O   1 
HETATM 3378 O O   . HOH B 2 .   ? -31.12147 -56.76926 -32.39738 1.000 39.03798 ? 812  HOH A O   1 
HETATM 3379 O O   . HOH B 2 .   ? -4.98448  31.62587  2.88256   1.000 32.92197 ? 813  HOH A O   1 
HETATM 3380 O O   . HOH B 2 .   ? -18.10755 -24.19572 -16.95300 1.000 50.08997 ? 814  HOH A O   1 
HETATM 3381 O O   . HOH B 2 .   ? -25.79346 5.41649   -14.29439 1.000 31.66832 ? 815  HOH A O   1 
HETATM 3382 O O   . HOH B 2 .   ? -32.27932 -6.03811  3.12415   1.000 40.22892 ? 816  HOH A O   1 
HETATM 3383 O O   . HOH B 2 .   ? -24.52441 -23.51450 -8.52514  1.000 25.59214 ? 817  HOH A O   1 
HETATM 3384 O O   . HOH B 2 .   ? -37.62363 -42.40008 -32.64568 1.000 33.92225 ? 818  HOH A O   1 
HETATM 3385 O O   . HOH B 2 .   ? -28.42162 10.20439  -33.28834 1.000 30.50384 ? 819  HOH A O   1 
HETATM 3386 O O   . HOH B 2 .   ? 17.95352  13.80783  -5.09955  1.000 25.63575 ? 820  HOH A O   1 
HETATM 3387 O O   . HOH B 2 .   ? -18.80802 -4.09479  4.79861   1.000 27.16232 ? 821  HOH A O   1 
HETATM 3388 O O   . HOH B 2 .   ? -4.29360  9.72005   1.04520   1.000 33.48127 ? 822  HOH A O   1 
HETATM 3389 O O   . HOH B 2 .   ? -33.76535 16.67307  -30.99589 1.000 36.22143 ? 823  HOH A O   1 
HETATM 3390 O O   . HOH B 2 .   ? 3.73963   33.50992  7.16873   1.000 37.05380 ? 824  HOH A O   1 
HETATM 3391 O O   . HOH B 2 .   ? -13.84575 10.48032  -17.46267 1.000 30.13539 ? 825  HOH A O   1 
HETATM 3392 O O   . HOH B 2 .   ? -1.11404  17.31503  -40.70043 1.000 47.14227 ? 826  HOH A O   1 
HETATM 3393 O O   . HOH B 2 .   ? -29.609   -43.051   -18.291   1.000 41.10618 ? 827  HOH A O   1 
HETATM 3394 O O   . HOH B 2 .   ? -6.88401  32.44810  -26.22342 1.000 49.91806 ? 828  HOH A O   1 
HETATM 3395 O O   . HOH B 2 .   ? -22.52134 -21.98818 -25.99397 1.000 33.33804 ? 829  HOH A O   1 
HETATM 3396 O O   . HOH B 2 .   ? -33.00365 -7.54158  -5.35271  1.000 31.73045 ? 830  HOH A O   1 
HETATM 3397 O O   . HOH B 2 .   ? 6.45864   29.28450  -11.00572 1.000 32.94022 ? 831  HOH A O   1 
HETATM 3398 O O   . HOH B 2 .   ? -25.89642 21.01720  -38.56904 1.000 30.07722 ? 832  HOH A O   1 
HETATM 3399 O O   . HOH B 2 .   ? -33.06763 -17.24915 -16.05609 1.000 27.09786 ? 833  HOH A O   1 
HETATM 3400 O O   . HOH B 2 .   ? -17.85130 -23.47221 -26.35363 1.000 31.97906 ? 834  HOH A O   1 
HETATM 3401 O O   . HOH B 2 .   ? -40.20560 -21.23974 -26.37205 1.000 20.18965 ? 835  HOH A O   1 
HETATM 3402 O O   . HOH B 2 .   ? -34.478   -19.847   -1.050    1.000 30.04415 ? 836  HOH A O   1 
HETATM 3403 O O   . HOH B 2 .   ? -11.03578 -8.63914  -7.62380  1.000 23.04160 ? 837  HOH A O   1 
HETATM 3404 O O   . HOH B 2 .   ? -17.30727 -13.54824 -18.31830 1.000 15.43334 ? 838  HOH A O   1 
HETATM 3405 O O   . HOH B 2 .   ? -19.10509 -20.50853 -19.59107 1.000 28.26711 ? 839  HOH A O   1 
HETATM 3406 O O   . HOH B 2 .   ? 17.72555  14.48012  -2.90590  1.000 22.45492 ? 840  HOH A O   1 
HETATM 3407 O O   . HOH B 2 .   ? -5.47880  24.69577  -14.88220 1.000 22.38039 ? 841  HOH A O   1 
HETATM 3408 O O   . HOH B 2 .   ? -7.83624  3.96232   -26.63859 1.000 43.27126 ? 842  HOH A O   1 
HETATM 3409 O O   . HOH B 2 .   ? -15.25186 -4.47099  -20.33215 1.000 35.82198 ? 843  HOH A O   1 
HETATM 3410 O O   . HOH B 2 .   ? -28.36792 8.58798   -1.47290  1.000 32.74443 ? 844  HOH A O   1 
HETATM 3411 O O   . HOH B 2 .   ? -37.76299 -37.97763 -25.19854 1.000 29.84349 ? 845  HOH A O   1 
HETATM 3412 O O   . HOH B 2 .   ? -22.33476 17.42430  -13.32701 1.000 32.13509 ? 846  HOH A O   1 
HETATM 3413 O O   . HOH B 2 .   ? -26.75183 -23.08415 -28.67121 1.000 28.83213 ? 847  HOH A O   1 
HETATM 3414 O O   . HOH B 2 .   ? -17.69491 10.16132  -15.34525 1.000 30.22412 ? 848  HOH A O   1 
HETATM 3415 O O   . HOH B 2 .   ? -4.24963  30.07455  -4.73761  1.000 24.62341 ? 849  HOH A O   1 
HETATM 3416 O O   . HOH B 2 .   ? 5.10253   13.38438  3.35835   1.000 29.03905 ? 850  HOH A O   1 
HETATM 3417 O O   . HOH B 2 .   ? -7.68734  18.36095  8.44675   1.000 37.08786 ? 851  HOH A O   1 
HETATM 3418 O O   . HOH B 2 .   ? -27.49333 -14.73202 -18.95738 1.000 18.45510 ? 852  HOH A O   1 
HETATM 3419 O O   . HOH B 2 .   ? -36.71406 -39.61256 -37.12142 1.000 36.58962 ? 853  HOH A O   1 
HETATM 3420 O O   . HOH B 2 .   ? -32.374   18.249    -39.695   1.000 35.39308 ? 854  HOH A O   1 
HETATM 3421 O O   . HOH B 2 .   ? -34.87366 -38.32313 -19.26757 1.000 36.96228 ? 855  HOH A O   1 
HETATM 3422 O O   . HOH B 2 .   ? -16.64628 -7.54460  -23.84573 1.000 42.74778 ? 856  HOH A O   1 
HETATM 3423 O O   . HOH B 2 .   ? -29.86609 -16.62773 -12.61152 1.000 15.18253 ? 857  HOH A O   1 
HETATM 3424 O O   . HOH B 2 .   ? -27.11120 -36.13577 -33.53800 1.000 30.53515 ? 858  HOH A O   1 
HETATM 3425 O O   . HOH B 2 .   ? -30.51078 7.33396   -1.17576  1.000 25.15514 ? 859  HOH A O   1 
HETATM 3426 O O   . HOH B 2 .   ? -25.14845 -40.51936 -17.90193 1.000 28.59185 ? 860  HOH A O   1 
HETATM 3427 O O   . HOH B 2 .   ? 2.44379   31.01021  -5.28016  1.000 34.81790 ? 861  HOH A O   1 
HETATM 3428 O O   . HOH B 2 .   ? 18.75456  23.85121  -4.29863  1.000 41.02917 ? 862  HOH A O   1 
HETATM 3429 O O   . HOH B 2 .   ? 5.36141   20.70188  -19.53355 1.000 36.14402 ? 863  HOH A O   1 
HETATM 3430 O O   . HOH B 2 .   ? -24.96690 24.26698  -30.01822 1.000 29.31833 ? 864  HOH A O   1 
HETATM 3431 O O   . HOH B 2 .   ? 0.06799   16.03385  6.77390   1.000 39.99644 ? 865  HOH A O   1 
HETATM 3432 O O   . HOH B 2 .   ? -22.94324 -27.09179 -30.26572 1.000 41.58882 ? 866  HOH A O   1 
HETATM 3433 O O   . HOH B 2 .   ? -11.30744 0.62629   4.61428   1.000 36.87016 ? 867  HOH A O   1 
HETATM 3434 O O   . HOH B 2 .   ? -15.12786 -15.90811 -28.60902 1.000 41.79858 ? 868  HOH A O   1 
HETATM 3435 O O   . HOH B 2 .   ? -19.96053 27.08755  -29.19079 1.000 33.66379 ? 869  HOH A O   1 
HETATM 3436 O O   . HOH B 2 .   ? -10.12621 -8.57347  -17.31368 1.000 35.12385 ? 870  HOH A O   1 
HETATM 3437 O O   . HOH B 2 .   ? -10.16190 5.46798   -10.44347 1.000 39.91814 ? 871  HOH A O   1 
HETATM 3438 O O   . HOH B 2 .   ? 10.65229  7.19614   -2.12945  1.000 41.71136 ? 872  HOH A O   1 
HETATM 3439 O O   . HOH B 2 .   ? -16.98766 10.00621  -9.05294  1.000 39.27717 ? 873  HOH A O   1 
HETATM 3440 O O   . HOH B 2 .   ? -23.71656 16.28365  -11.17685 1.000 27.67655 ? 874  HOH A O   1 
HETATM 3441 O O   . HOH B 2 .   ? -20.56455 -38.01970 -13.23614 1.000 37.07491 ? 875  HOH A O   1 
HETATM 3442 O O   . HOH B 2 .   ? -18.71120 -15.41323 -16.75207 1.000 15.16386 ? 876  HOH A O   1 
HETATM 3443 O O   . HOH B 2 .   ? -13.66764 5.15938   -14.01764 1.000 34.77758 ? 877  HOH A O   1 
HETATM 3444 O O   . HOH B 2 .   ? -22.61148 -39.88482 -17.32240 1.000 44.77842 ? 878  HOH A O   1 
HETATM 3445 O O   . HOH B 2 .   ? -23.33048 -26.63347 -11.59878 1.000 31.17654 ? 879  HOH A O   1 
HETATM 3446 O O   . HOH B 2 .   ? -15.60912 17.35799  -36.48661 1.000 23.27980 ? 880  HOH A O   1 
HETATM 3447 O O   . HOH B 2 .   ? -17.60826 21.85516  -34.12961 1.000 30.29261 ? 881  HOH A O   1 
HETATM 3448 O O   . HOH B 2 .   ? -23.18428 25.07967  -32.11190 1.000 31.95914 ? 882  HOH A O   1 
HETATM 3449 O O   . HOH B 2 .   ? -30.23509 10.09444  -15.17662 1.000 35.56837 ? 883  HOH A O   1 
HETATM 3450 O O   . HOH B 2 .   ? -28.90410 -10.60713 3.44968   1.000 46.48021 ? 884  HOH A O   1 
HETATM 3451 O O   . HOH B 2 .   ? -25.32029 -13.29318 -18.13127 1.000 14.14427 ? 885  HOH A O   1 
HETATM 3452 O O   . HOH B 2 .   ? -35.09735 -5.50642  -14.71478 1.000 43.40572 ? 886  HOH A O   1 
HETATM 3453 O O   . HOH B 2 .   ? -11.80161 32.82628  -18.79568 1.000 40.69408 ? 887  HOH A O   1 
HETATM 3454 O O   . HOH B 2 .   ? -3.47524  22.99057  11.07347  1.000 29.93285 ? 888  HOH A O   1 
HETATM 3455 O O   . HOH B 2 .   ? -31.83519 -15.15307 -19.17428 1.000 29.16777 ? 889  HOH A O   1 
HETATM 3456 O O   . HOH B 2 .   ? -32.51726 -40.14046 -20.28385 1.000 32.02863 ? 890  HOH A O   1 
HETATM 3457 O O   . HOH B 2 .   ? -26.02838 -28.56200 -6.56744  1.000 36.56607 ? 891  HOH A O   1 
HETATM 3458 O O   . HOH B 2 .   ? -32.00385 -55.91301 -23.41123 1.000 45.55486 ? 892  HOH A O   1 
HETATM 3459 O O   . HOH B 2 .   ? -24.30571 18.54095  -9.01885  1.000 28.45399 ? 893  HOH A O   1 
HETATM 3460 O O   . HOH B 2 .   ? -10.017   -5.414    0.278     1.000 38.03995 ? 894  HOH A O   1 
HETATM 3461 O O   . HOH B 2 .   ? 8.37847   25.50999  -18.78747 1.000 40.79220 ? 895  HOH A O   1 
HETATM 3462 O O   . HOH B 2 .   ? -20.94403 -11.92064 -25.36068 1.000 33.68232 ? 896  HOH A O   1 
HETATM 3463 O O   . HOH B 2 .   ? -22.50980 -27.11839 -24.72361 1.000 27.27405 ? 897  HOH A O   1 
HETATM 3464 O O   . HOH B 2 .   ? 22.56187  18.65708  -2.10941  1.000 35.43788 ? 898  HOH A O   1 
HETATM 3465 O O   . HOH B 2 .   ? -27.04078 -10.43751 0.14599   1.000 20.08203 ? 899  HOH A O   1 
HETATM 3466 O O   . HOH B 2 .   ? -17.70416 13.32550  1.57091   1.000 49.13905 ? 900  HOH A O   1 
HETATM 3467 O O   . HOH B 2 .   ? -31.79024 -38.67167 -7.29857  1.000 34.34080 ? 901  HOH A O   1 
HETATM 3468 O O   . HOH B 2 .   ? -37.707   -39.709   -9.220    1.000 38.80740 ? 902  HOH A O   1 
HETATM 3469 O O   . HOH B 2 .   ? -37.67993 -37.71371 -22.87187 1.000 39.88410 ? 903  HOH A O   1 
HETATM 3470 O O   . HOH B 2 .   ? -14.17642 -8.21980  3.60102   1.000 38.95853 ? 904  HOH A O   1 
HETATM 3471 O O   . HOH B 2 .   ? -25.491   4.595     -28.184   1.000 37.09464 ? 905  HOH A O   1 
HETATM 3472 O O   . HOH B 2 .   ? -29.22852 -17.11790 -1.69945  1.000 40.44631 ? 906  HOH A O   1 
HETATM 3473 O O   . HOH B 2 .   ? -21.12933 27.51669  -37.95476 1.000 34.15256 ? 907  HOH A O   1 
HETATM 3474 O O   . HOH B 2 .   ? -11.10820 29.54879  -28.79998 1.000 40.24187 ? 908  HOH A O   1 
HETATM 3475 O O   . HOH B 2 .   ? -13.52803 5.03439   0.76273   1.000 36.98121 ? 909  HOH A O   1 
HETATM 3476 O O   . HOH B 2 .   ? -3.28687  15.89482  -21.36359 1.000 39.07746 ? 910  HOH A O   1 
HETATM 3477 O O   . HOH B 2 .   ? -12.49504 -5.74599  3.29849   1.000 34.06460 ? 911  HOH A O   1 
HETATM 3478 O O   . HOH B 2 .   ? 0.82519   10.40648  -7.71641  1.000 38.32583 ? 912  HOH A O   1 
HETATM 3479 O O   . HOH B 2 .   ? -7.80891  28.22109  8.97817   1.000 41.14940 ? 913  HOH A O   1 
HETATM 3480 O O   . HOH B 2 .   ? -17.49834 19.45855  -39.52723 1.000 40.84568 ? 914  HOH A O   1 
HETATM 3481 O O   . HOH B 2 .   ? -33.92857 -51.60773 -33.18085 1.000 44.56730 ? 915  HOH A O   1 
HETATM 3482 O O   . HOH B 2 .   ? 5.634     34.877    -6.179    1.000 35.84772 ? 916  HOH A O   1 
HETATM 3483 O O   . HOH B 2 .   ? 7.00376   11.75921  -1.72597  1.000 31.85575 ? 917  HOH A O   1 
HETATM 3484 O O   . HOH B 2 .   ? -27.24017 7.37833   -25.47944 1.000 30.50431 ? 918  HOH A O   1 
HETATM 3485 O O   . HOH B 2 .   ? 7.005     33.883    2.474     1.000 31.68291 ? 919  HOH A O   1 
HETATM 3486 O O   . HOH B 2 .   ? 4.24610   11.94120  -0.95885  1.000 34.02253 ? 920  HOH A O   1 
HETATM 3487 O O   . HOH B 2 .   ? -30.70498 -29.99657 -33.14711 1.000 33.56255 ? 921  HOH A O   1 
HETATM 3488 O O   . HOH B 2 .   ? -16.22814 13.71378  -12.64450 1.000 37.15713 ? 922  HOH A O   1 
HETATM 3489 O O   . HOH B 2 .   ? -17.38646 -24.82566 -21.77019 1.000 36.83811 ? 923  HOH A O   1 
HETATM 3490 O O   . HOH B 2 .   ? -11.87228 4.13930   -12.62205 1.000 35.00503 ? 924  HOH A O   1 
HETATM 3491 O O   . HOH B 2 .   ? -2.85999  11.72815  2.74709   1.000 41.65055 ? 925  HOH A O   1 
HETATM 3492 O O   . HOH B 2 .   ? -23.57586 -19.11702 -12.43077 1.000 28.03975 ? 926  HOH A O   1 
HETATM 3493 O O   . HOH B 2 .   ? -1.00194  33.07210  -1.31754  1.000 36.42657 ? 927  HOH A O   1 
HETATM 3494 O O   . HOH B 2 .   ? -42.80623 -31.73762 -24.57560 1.000 34.42310 ? 928  HOH A O   1 
HETATM 3495 O O   . HOH B 2 .   ? -5.16467  24.86772  -30.16122 1.000 44.31874 ? 929  HOH A O   1 
HETATM 3496 O O   . HOH B 2 .   ? -11.87913 15.52343  -11.85134 1.000 28.82724 ? 930  HOH A O   1 
HETATM 3497 O O   . HOH B 2 .   ? -45.74483 -29.70491 -17.61142 1.000 52.75662 ? 931  HOH A O   1 
HETATM 3498 O O   . HOH B 2 .   ? -23.43792 -11.23671 -25.41065 1.000 38.20229 ? 932  HOH A O   1 
HETATM 3499 O O   . HOH B 2 .   ? -24.60693 9.33797   -15.19224 1.000 35.64527 ? 933  HOH A O   1 
HETATM 3500 O O   . HOH B 2 .   ? -20.36830 15.40447  1.63565   1.000 40.37523 ? 934  HOH A O   1 
HETATM 3501 O O   . HOH B 2 .   ? -30.116   -6.651    7.771     1.000 41.90213 ? 935  HOH A O   1 
HETATM 3502 O O   . HOH B 2 .   ? -29.53824 12.28629  -9.48784  1.000 33.89430 ? 936  HOH A O   1 
HETATM 3503 O O   . HOH B 2 .   ? -18.67847 7.88568   -17.27080 1.000 27.77327 ? 937  HOH A O   1 
HETATM 3504 O O   . HOH B 2 .   ? -5.24387  5.84494   -16.90908 1.000 49.84424 ? 938  HOH A O   1 
HETATM 3505 O O   . HOH B 2 .   ? -13.20422 19.28365  -40.01449 1.000 47.88381 ? 939  HOH A O   1 
HETATM 3506 O O   . HOH B 2 .   ? -16.92421 -23.58364 -19.75194 1.000 41.25467 ? 940  HOH A O   1 
HETATM 3507 O O   . HOH B 2 .   ? 15.61241  21.60309  -13.93691 1.000 34.75351 ? 941  HOH A O   1 
HETATM 3508 O O   . HOH B 2 .   ? -8.47682  8.73286   -28.77075 1.000 47.33586 ? 942  HOH A O   1 
HETATM 3509 O O   . HOH B 2 .   ? -26.250   -8.606    8.582     1.000 37.05788 ? 943  HOH A O   1 
HETATM 3510 O O   . HOH B 2 .   ? -33.95527 -38.19212 -6.98915  1.000 40.63115 ? 944  HOH A O   1 
HETATM 3511 O O   . HOH B 2 .   ? -1.35309  13.36504  -16.19884 1.000 30.88835 ? 945  HOH A O   1 
HETATM 3512 O O   . HOH B 2 .   ? -22.20555 -30.31216 -31.76602 1.000 45.40908 ? 946  HOH A O   1 
HETATM 3513 O O   . HOH B 2 .   ? 10.75021  32.84204  -12.12009 1.000 48.02069 ? 947  HOH A O   1 
HETATM 3514 O O   . HOH B 2 .   ? -16.02065 13.90235  0.21064   1.000 44.13866 ? 948  HOH A O   1 
HETATM 3515 O O   . HOH B 2 .   ? -38.913   -33.943   -33.213   1.000 32.75615 ? 949  HOH A O   1 
HETATM 3516 O O   . HOH B 2 .   ? -19.22077 1.28591   -28.22774 1.000 28.68546 ? 950  HOH A O   1 
HETATM 3517 O O   . HOH B 2 .   ? -33.193   -32.476   -35.113   1.000 31.47566 ? 951  HOH A O   1 
HETATM 3518 O O   . HOH B 2 .   ? -36.17382 -13.84175 -13.77076 1.000 42.10131 ? 952  HOH A O   1 
HETATM 3519 O O   . HOH B 2 .   ? 8.62974   29.86482  4.15295   1.000 27.43688 ? 953  HOH A O   1 
HETATM 3520 O O   . HOH B 2 .   ? -6.98374  3.77378   -21.86533 1.000 49.42005 ? 954  HOH A O   1 
HETATM 3521 O O   . HOH B 2 .   ? -32.51701 -16.99257 -13.50784 1.000 22.37653 ? 955  HOH A O   1 
HETATM 3522 O O   . HOH B 2 .   ? -17.49475 15.08028  -1.37403  1.000 43.25623 ? 956  HOH A O   1 
HETATM 3523 O O   . HOH B 2 .   ? 0.46659   31.26116  -1.42060  1.000 30.35974 ? 957  HOH A O   1 
HETATM 3524 O O   . HOH B 2 .   ? -24.129   -8.081    7.783     1.000 54.04243 ? 958  HOH A O   1 
HETATM 3525 O O   . HOH B 2 .   ? 10.22241  13.38498  -0.38406  1.000 33.06191 ? 959  HOH A O   1 
HETATM 3526 O O   . HOH B 2 .   ? 9.498     6.978     -4.663    1.000 39.36330 ? 960  HOH A O   1 
HETATM 3527 O O   . HOH B 2 .   ? -16.79138 1.80723   -35.88984 1.000 31.00018 ? 961  HOH A O   1 
HETATM 3528 O O   . HOH B 2 .   ? -33.19696 -15.20349 -8.40154  1.000 36.95034 ? 962  HOH A O   1 
HETATM 3529 O O   . HOH B 2 .   ? -24.30859 26.81333  -28.95573 1.000 44.25596 ? 963  HOH A O   1 
HETATM 3530 O O   . HOH B 2 .   ? 14.48673  25.88428  -13.85275 1.000 38.33646 ? 964  HOH A O   1 
HETATM 3531 O O   . HOH B 2 .   ? -23.216   -38.711   -24.457   1.000 52.73572 ? 965  HOH A O   1 
HETATM 3532 O O   . HOH B 2 .   ? -28.51022 1.65349   -19.41333 1.000 43.54628 ? 966  HOH A O   1 
HETATM 3533 O O   . HOH B 2 .   ? -20.39279 -8.14529  5.53476   1.000 39.78969 ? 967  HOH A O   1 
HETATM 3534 O O   . HOH B 2 .   ? -29.659   13.302    -41.311   1.000 30.27508 ? 968  HOH A O   1 
HETATM 3535 O O   . HOH B 2 .   ? -33.65963 -53.00877 -35.48230 1.000 43.71572 ? 969  HOH A O   1 
HETATM 3536 O O   . HOH B 2 .   ? -30.54804 20.41529  -38.52616 1.000 36.99583 ? 970  HOH A O   1 
HETATM 3537 O O   . HOH B 2 .   ? 11.52727  21.39540  8.30582   1.000 43.52747 ? 971  HOH A O   1 
HETATM 3538 O O   . HOH B 2 .   ? 3.22693   30.05853  -11.98166 1.000 35.15011 ? 972  HOH A O   1 
HETATM 3539 O O   . HOH B 2 .   ? -14.25223 8.80445   -6.80159  1.000 36.54930 ? 973  HOH A O   1 
HETATM 3540 O O   . HOH B 2 .   ? -1.53806  9.27530   -14.62862 1.000 36.01684 ? 974  HOH A O   1 
HETATM 3541 O O   . HOH B 2 .   ? -8.58174  30.08123  -4.85725  1.000 38.04432 ? 975  HOH A O   1 
HETATM 3542 O O   . HOH B 2 .   ? -2.99486  11.36620  -27.83323 1.000 38.41143 ? 976  HOH A O   1 
HETATM 3543 O O   . HOH B 2 .   ? -13.08333 -13.53476 -21.45010 1.000 37.87539 ? 977  HOH A O   1 
HETATM 3544 O O   . HOH B 2 .   ? -12.46286 12.44602  -38.56056 1.000 33.75533 ? 978  HOH A O   1 
HETATM 3545 O O   . HOH B 2 .   ? -26.04141 10.89283  -14.31243 1.000 31.37877 ? 979  HOH A O   1 
HETATM 3546 O O   . HOH B 2 .   ? -10.676   9.474     -38.774   1.000 40.28533 ? 980  HOH A O   1 
HETATM 3547 O O   . HOH B 2 .   ? -3.47318  22.44055  -31.02182 1.000 47.01214 ? 981  HOH A O   1 
HETATM 3548 O O   . HOH B 2 .   ? -13.15194 21.65944  -34.28030 1.000 41.24196 ? 982  HOH A O   1 
HETATM 3549 O O   . HOH B 2 .   ? 15.13254  20.95272  -16.46435 1.000 30.46806 ? 983  HOH A O   1 
HETATM 3550 O O   . HOH B 2 .   ? -25.48159 -37.37268 -28.56816 1.000 32.97995 ? 984  HOH A O   1 
HETATM 3551 O O   . HOH B 2 .   ? -13.82075 14.04536  -12.07249 1.000 33.28923 ? 985  HOH A O   1 
HETATM 3552 O O   . HOH B 2 .   ? -10.018   -6.380    -9.611    1.000 27.75024 ? 986  HOH A O   1 
HETATM 3553 O O   . HOH B 2 .   ? -44.36290 -27.79608 -22.90598 1.000 36.33966 ? 987  HOH A O   1 
HETATM 3554 O O   . HOH B 2 .   ? 3.60830   7.39584   -10.82825 1.000 41.04032 ? 988  HOH A O   1 
HETATM 3555 O O   . HOH B 2 .   ? -14.63815 -13.44151 -19.29194 1.000 18.85770 ? 989  HOH A O   1 
HETATM 3556 O O   . HOH B 2 .   ? -20.835   21.304    -43.196   1.000 44.80401 ? 990  HOH A O   1 
HETATM 3557 O O   . HOH B 2 .   ? -5.804    -5.759    -11.821   1.000 40.23344 ? 991  HOH A O   1 
HETATM 3558 O O   . HOH B 2 .   ? -14.57015 11.06038  -39.51677 1.000 31.07053 ? 992  HOH A O   1 
HETATM 3559 O O   . HOH B 2 .   ? 19.95958  17.64070  -7.58628  1.000 27.45167 ? 993  HOH A O   1 
HETATM 3560 O O   . HOH B 2 .   ? 7.15267   25.58249  -20.71698 1.000 46.16119 ? 994  HOH A O   1 
HETATM 3561 O O   . HOH B 2 .   ? -33.459   12.689    -6.135    1.000 41.32137 ? 995  HOH A O   1 
HETATM 3562 O O   . HOH B 2 .   ? -7.55126  8.07992   -23.68373 1.000 34.00035 ? 996  HOH A O   1 
HETATM 3563 O O   . HOH B 2 .   ? -33.41481 1.12414   -12.39844 1.000 46.10292 ? 997  HOH A O   1 
HETATM 3564 O O   . HOH B 2 .   ? -27.16361 -33.30053 -33.51216 1.000 38.07208 ? 998  HOH A O   1 
HETATM 3565 O O   . HOH B 2 .   ? -11.95762 -16.88525 -24.78799 1.000 42.44059 ? 999  HOH A O   1 
HETATM 3566 O O   . HOH B 2 .   ? 6.99918   13.68728  -18.92401 1.000 35.77906 ? 1000 HOH A O   1 
HETATM 3567 O O   . HOH B 2 .   ? -29.25931 8.07420   -15.00979 1.000 55.20009 ? 1001 HOH A O   1 
HETATM 3568 O O   . HOH B 2 .   ? -13.012   8.523     -39.820   1.000 32.71775 ? 1002 HOH A O   1 
HETATM 3569 O O   . HOH B 2 .   ? -23.83815 4.29498   -16.02399 1.000 40.46510 ? 1003 HOH A O   1 
HETATM 3570 O O   . HOH B 2 .   ? -30.21130 7.91875   -19.41110 1.000 37.11314 ? 1004 HOH A O   1 
HETATM 3571 O O   . HOH B 2 .   ? -10.06811 8.23124   -15.03820 1.000 44.24401 ? 1005 HOH A O   1 
HETATM 3572 O O   . HOH B 2 .   ? -26.66621 -11.21323 -22.05276 1.000 24.67954 ? 1006 HOH A O   1 
HETATM 3573 O O   . HOH B 2 .   ? -21.04742 23.93432  -12.78511 1.000 45.07172 ? 1007 HOH A O   1 
HETATM 3574 O O   . HOH B 2 .   ? -14.69432 27.30690  -3.05980  1.000 40.57718 ? 1008 HOH A O   1 
HETATM 3575 O O   . HOH B 2 .   ? 0.71300   20.91575  11.50608  1.000 42.37819 ? 1009 HOH A O   1 
HETATM 3576 O O   . HOH B 2 .   ? -22.32239 -19.83421 -14.47445 1.000 22.54329 ? 1010 HOH A O   1 
HETATM 3577 O O   . HOH B 2 .   ? -9.04312  6.45994   -30.93896 1.000 29.49814 ? 1011 HOH A O   1 
HETATM 3578 O O   . HOH B 2 .   ? -29.33193 -35.54462 -35.62773 1.000 41.50083 ? 1012 HOH A O   1 
HETATM 3579 O O   . HOH B 2 .   ? -1.28739  14.71300  3.31302   1.000 27.58220 ? 1013 HOH A O   1 
HETATM 3580 O O   . HOH B 2 .   ? 3.11484   25.82945  11.06453  1.000 52.06300 ? 1014 HOH A O   1 
HETATM 3581 O O   . HOH B 2 .   ? -14.82427 15.56366  -38.89904 1.000 37.10532 ? 1015 HOH A O   1 
HETATM 3582 O O   . HOH B 2 .   ? -35.17836 -20.93732 -14.72112 1.000 31.22064 ? 1016 HOH A O   1 
HETATM 3583 O O   . HOH B 2 .   ? -33.590   -31.840   -32.526   1.000 30.39623 ? 1017 HOH A O   1 
HETATM 3584 O O   . HOH B 2 .   ? -32.47002 -8.85927  -9.59657  1.000 31.94657 ? 1018 HOH A O   1 
HETATM 3585 O O   . HOH B 2 .   ? -29.23779 10.00381  -13.18411 1.000 32.68790 ? 1019 HOH A O   1 
HETATM 3586 O O   . HOH B 2 .   ? -42.71010 -31.37563 -20.10450 1.000 39.46333 ? 1020 HOH A O   1 
HETATM 3587 O O   . HOH B 2 .   ? -16.73542 -4.50947  7.55415   1.000 32.03516 ? 1021 HOH A O   1 
HETATM 3588 O O   . HOH B 2 .   ? 3.80370   30.36903  -7.37011  1.000 37.53830 ? 1022 HOH A O   1 
HETATM 3589 O O   . HOH B 2 .   ? -15.22178 5.76756   -15.38101 1.000 35.56981 ? 1023 HOH A O   1 
HETATM 3590 O O   . HOH B 2 .   ? -27.62675 5.72418   -20.51664 1.000 47.03071 ? 1024 HOH A O   1 
HETATM 3591 O O   . HOH B 2 .   ? -11.71893 8.18200   -13.72818 1.000 45.61545 ? 1025 HOH A O   1 
HETATM 3592 O O   . HOH B 2 .   ? -4.00802  30.73423  7.73998   1.000 44.86519 ? 1026 HOH A O   1 
HETATM 3593 O O   . HOH B 2 .   ? -0.22201  26.29191  -20.02147 1.000 27.55978 ? 1027 HOH A O   1 
HETATM 3594 O O   . HOH B 2 .   ? -25.61767 10.39770  0.78396   1.000 37.29592 ? 1028 HOH A O   1 
HETATM 3595 O O   . HOH B 2 .   ? -14.38295 29.59606  -7.19958  1.000 38.21666 ? 1029 HOH A O   1 
HETATM 3596 O O   . HOH B 2 .   ? -5.78106  28.94590  -20.19117 1.000 41.85269 ? 1030 HOH A O   1 
HETATM 3597 O O   . HOH B 2 .   ? -42.20269 -16.97877 -22.53381 1.000 53.55776 ? 1031 HOH A O   1 
HETATM 3598 O O   . HOH B 2 .   ? -28.416   -27.312   -35.288   1.000 46.18240 ? 1032 HOH A O   1 
HETATM 3599 O O   . HOH B 2 .   ? -20.376   29.756    -19.589   1.000 40.00298 ? 1033 HOH A O   1 
HETATM 3600 O O   . HOH B 2 .   ? -44.33735 -28.68672 -12.49740 1.000 45.51546 ? 1034 HOH A O   1 
HETATM 3601 O O   . HOH B 2 .   ? -33.31488 -17.53228 -6.57779  1.000 33.79695 ? 1035 HOH A O   1 
HETATM 3602 O O   . HOH B 2 .   ? -19.10367 -21.44332 -17.42960 1.000 35.92504 ? 1036 HOH A O   1 
HETATM 3603 O O   . HOH B 2 .   ? 8.02241   21.15917  -23.79552 1.000 42.09908 ? 1037 HOH A O   1 
HETATM 3604 O O   . HOH B 2 .   ? -14.47024 -10.00144 2.19289   1.000 32.47216 ? 1038 HOH A O   1 
HETATM 3605 O O   . HOH B 2 .   ? 2.64736   23.02049  -20.40197 1.000 32.46163 ? 1039 HOH A O   1 
HETATM 3606 O O   . HOH B 2 .   ? 2.90337   34.41933  4.40943   1.000 36.90408 ? 1040 HOH A O   1 
HETATM 3607 O O   . HOH B 2 .   ? 5.56169   22.75270  -19.65838 1.000 40.09233 ? 1041 HOH A O   1 
HETATM 3608 O O   . HOH B 2 .   ? -12.21509 18.94093  -41.73826 1.000 46.42648 ? 1042 HOH A O   1 
HETATM 3609 O O   . HOH B 2 .   ? -39.30933 -42.19171 -22.36768 1.000 47.67092 ? 1043 HOH A O   1 
HETATM 3610 O O   . HOH B 2 .   ? -31.65048 8.22508   -21.27690 1.000 38.96356 ? 1044 HOH A O   1 
HETATM 3611 O O   . HOH B 2 .   ? -10.70441 10.09470  -2.29901  1.000 35.95099 ? 1045 HOH A O   1 
HETATM 3612 O O   . HOH B 2 .   ? 22.163    14.693    1.290     1.000 43.22538 ? 1046 HOH A O   1 
HETATM 3613 O O   . HOH B 2 .   ? -5.94135  26.88703  -16.27596 1.000 37.19324 ? 1047 HOH A O   1 
HETATM 3614 O O   . HOH B 2 .   ? -32.00372 -8.70135  -18.07034 1.000 30.21970 ? 1048 HOH A O   1 
HETATM 3615 O O   . HOH B 2 .   ? 21.69644  19.38071  -6.42707  1.000 33.50495 ? 1049 HOH A O   1 
HETATM 3616 O O   . HOH B 2 .   ? -22.59211 -0.92878  -26.64847 1.000 41.40551 ? 1050 HOH A O   1 
HETATM 3617 O O   . HOH B 2 .   ? -20.48790 -25.71965 -8.85152  1.000 39.31926 ? 1051 HOH A O   1 
HETATM 3618 O O   . HOH B 2 .   ? -23.10697 -8.83418  -27.76934 1.000 37.84165 ? 1052 HOH A O   1 
HETATM 3619 O O   . HOH B 2 .   ? -24.600   17.955    -42.026   1.000 32.18169 ? 1053 HOH A O   1 
HETATM 3620 O O   . HOH B 2 .   ? -22.91031 6.78107   -17.34510 1.000 42.58684 ? 1054 HOH A O   1 
HETATM 3621 O O   . HOH B 2 .   ? -17.34393 -14.79209 1.79173   1.000 37.34247 ? 1055 HOH A O   1 
HETATM 3622 O O   . HOH B 2 .   ? -9.636    -9.042    -11.032   1.000 37.16437 ? 1056 HOH A O   1 
HETATM 3623 O O   . HOH B 2 .   ? -13.67257 11.76832  -14.55093 1.000 51.56711 ? 1057 HOH A O   1 
HETATM 3624 O O   . HOH B 2 .   ? 5.86767   9.77979   -13.59500 1.000 35.90236 ? 1058 HOH A O   1 
HETATM 3625 O O   . HOH B 2 .   ? -19.641   -6.027    -28.582   1.000 47.08619 ? 1059 HOH A O   1 
HETATM 3626 O O   . HOH B 2 .   ? -41.157   -37.637   -8.251    1.000 35.77934 ? 1060 HOH A O   1 
HETATM 3627 O O   . HOH B 2 .   ? -22.18379 27.33365  -30.86048 1.000 38.83201 ? 1061 HOH A O   1 
HETATM 3628 O O   . HOH B 2 .   ? -36.74302 -45.37909 -33.34467 1.000 45.35379 ? 1062 HOH A O   1 
HETATM 3629 O O   . HOH B 2 .   ? -6.22297  18.24418  10.47580  1.000 40.58741 ? 1063 HOH A O   1 
HETATM 3630 O O   . HOH B 2 .   ? -27.290   20.878    -1.482    1.000 37.46238 ? 1064 HOH A O   1 
HETATM 3631 O O   . HOH B 2 .   ? -19.46155 29.28145  -29.70965 1.000 43.77351 ? 1065 HOH A O   1 
HETATM 3632 O O   . HOH B 2 .   ? -40.21960 -37.11633 -17.55754 1.000 40.86265 ? 1066 HOH A O   1 
HETATM 3633 O O   . HOH B 2 .   ? -17.25623 -20.07281 -16.09276 1.000 42.95086 ? 1067 HOH A O   1 
HETATM 3634 O O   . HOH B 2 .   ? -9.02668  30.29134  -13.22253 1.000 40.14902 ? 1068 HOH A O   1 
HETATM 3635 O O   . HOH B 2 .   ? -32.43358 2.45237   5.69796   1.000 36.41093 ? 1069 HOH A O   1 
HETATM 3636 O O   . HOH B 2 .   ? -17.398   11.425    -4.122    1.000 36.89455 ? 1070 HOH A O   1 
HETATM 3637 O O   . HOH B 2 .   ? -33.880   20.562    -39.830   1.000 40.94382 ? 1071 HOH A O   1 
HETATM 3638 O O   . HOH B 2 .   ? 11.89328  19.41129  -18.93611 1.000 27.00637 ? 1072 HOH A O   1 
HETATM 3639 O O   . HOH B 2 .   ? -35.30338 -44.55631 -35.31423 1.000 44.12413 ? 1073 HOH A O   1 
HETATM 3640 O O   . HOH B 2 .   ? -16.65466 11.74860  -11.63634 1.000 33.52061 ? 1074 HOH A O   1 
HETATM 3641 O O   . HOH B 2 .   ? -8.01293  -1.39525  1.26292   1.000 45.38402 ? 1075 HOH A O   1 
HETATM 3642 O O   . HOH B 2 .   ? -20.785   3.701     -36.959   1.000 22.99491 ? 1076 HOH A O   1 
HETATM 3643 O O   . HOH B 2 .   ? -5.97165  31.63745  -9.82610  1.000 39.32295 ? 1077 HOH A O   1 
HETATM 3644 O O   . HOH B 2 .   ? -18.81412 8.20443   -11.56473 1.000 33.48043 ? 1078 HOH A O   1 
HETATM 3645 O O   . HOH B 2 .   ? -33.92930 -15.05848 -17.67274 1.000 41.40423 ? 1079 HOH A O   1 
HETATM 3646 O O   . HOH B 2 .   ? -19.82767 -14.37429 2.57765   1.000 38.16798 ? 1080 HOH A O   1 
HETATM 3647 O O   . HOH B 2 .   ? -1.10600  9.27457   -8.41110  1.000 38.88942 ? 1081 HOH A O   1 
HETATM 3648 O O   . HOH B 2 .   ? -24.90652 22.90568  -42.84429 1.000 40.62844 ? 1082 HOH A O   1 
HETATM 3649 O O   . HOH B 2 .   ? -24.59045 -13.55239 -24.64758 1.000 26.16582 ? 1083 HOH A O   1 
HETATM 3650 O O   . HOH B 2 .   ? -15.84188 12.08134  -8.98809  1.000 37.66302 ? 1084 HOH A O   1 
HETATM 3651 O O   . HOH B 2 .   ? -10.40007 2.12473   -7.63310  1.000 40.04868 ? 1085 HOH A O   1 
HETATM 3652 O O   . HOH B 2 .   ? 5.42766   9.39604   -18.14783 1.000 35.28941 ? 1086 HOH A O   1 
HETATM 3653 O O   . HOH B 2 .   ? -22.00741 8.13963   -14.69603 1.000 32.91713 ? 1087 HOH A O   1 
HETATM 3654 O O   . HOH B 2 .   ? -15.77497 30.78099  -25.53033 1.000 41.62040 ? 1088 HOH A O   1 
HETATM 3655 O O   . HOH B 2 .   ? -30.22568 8.19769   -17.19013 1.000 37.71968 ? 1089 HOH A O   1 
HETATM 3656 O O   . HOH B 2 .   ? -12.62003 2.61433   -1.57143  1.000 31.96167 ? 1090 HOH A O   1 
HETATM 3657 O O   . HOH B 2 .   ? -37.68507 -17.51628 -13.79693 1.000 40.23661 ? 1091 HOH A O   1 
HETATM 3658 O O   . HOH B 2 .   ? -19.040   -19.111   -9.540    1.000 35.18567 ? 1092 HOH A O   1 
HETATM 3659 O O   . HOH B 2 .   ? -32.09637 1.24268   -16.83148 1.000 36.93664 ? 1093 HOH A O   1 
HETATM 3660 O O   . HOH B 2 .   ? -28.049   -8.826    -25.058   1.000 49.28448 ? 1094 HOH A O   1 
HETATM 3661 O O   . HOH B 2 .   ? 15.37539  24.19077  -6.91639  1.000 33.54702 ? 1095 HOH A O   1 
HETATM 3662 O O   . HOH B 2 .   ? -21.790   -36.523   -27.701   1.000 39.72913 ? 1096 HOH A O   1 
HETATM 3663 O O   . HOH B 2 .   ? -9.68034  8.76098   -6.16329  1.000 40.14453 ? 1097 HOH A O   1 
HETATM 3664 O O   . HOH B 2 .   ? 11.31740  16.96524  -20.29205 1.000 34.10511 ? 1098 HOH A O   1 
HETATM 3665 O O   . HOH B 2 .   ? -23.352   -35.402   -32.879   1.000 40.49985 ? 1099 HOH A O   1 
HETATM 3666 O O   . HOH B 2 .   ? -19.88132 -28.97281 -25.75549 1.000 40.33435 ? 1100 HOH A O   1 
HETATM 3667 O O   . HOH B 2 .   ? -13.75577 10.55715  0.48976   1.000 36.37109 ? 1101 HOH A O   1 
HETATM 3668 O O   . HOH B 2 .   ? -15.57377 9.17879   2.13710   1.000 22.79835 ? 1102 HOH A O   1 
HETATM 3669 O O   . HOH B 2 .   ? -16.60401 28.54898  -4.21341  1.000 47.45869 ? 1103 HOH A O   1 
HETATM 3670 O O   . HOH B 2 .   ? -18.73430 0.10721   -24.56572 1.000 35.80115 ? 1104 HOH A O   1 
HETATM 3671 O O   . HOH B 2 .   ? -40.112   -18.426   -27.319   1.000 34.04237 ? 1105 HOH A O   1 
HETATM 3672 O O   . HOH B 2 .   ? -20.49236 28.57201  -35.88267 1.000 39.81070 ? 1106 HOH A O   1 
HETATM 3673 O O   . HOH B 2 .   ? 13.66750  10.29776  -0.08491  1.000 26.62746 ? 1107 HOH A O   1 
HETATM 3674 O O   . HOH B 2 .   ? -13.54804 7.69468   3.53673   1.000 40.10165 ? 1108 HOH A O   1 
HETATM 3675 O O   . HOH B 2 .   ? -10.94965 2.49763   -3.66223  1.000 44.86131 ? 1109 HOH A O   1 
HETATM 3676 O O   . HOH B 2 .   ? 2.98162   20.12850  -21.15543 1.000 36.43553 ? 1110 HOH A O   1 
HETATM 3677 O O   . HOH B 2 .   ? -20.538   27.632    4.723     1.000 48.84861 ? 1111 HOH A O   1 
HETATM 3678 O O   . HOH B 2 .   ? 15.28706  24.45516  -12.01205 1.000 43.47518 ? 1112 HOH A O   1 
HETATM 3679 O O   . HOH B 2 .   ? -38.71307 -41.72671 -34.98368 1.000 40.01437 ? 1113 HOH A O   1 
HETATM 3680 O O   . HOH B 2 .   ? 9.42496   26.09929  -16.59377 1.000 39.00642 ? 1114 HOH A O   1 
HETATM 3681 O O   . HOH B 2 .   ? -30.98639 -0.61521  -20.92125 1.000 39.74980 ? 1115 HOH A O   1 
HETATM 3682 O O   . HOH B 2 .   ? -14.89506 -18.38367 -28.85060 1.000 38.21390 ? 1116 HOH A O   1 
HETATM 3683 O O   . HOH B 2 .   ? -7.25894  29.11380  -14.90117 1.000 43.19888 ? 1117 HOH A O   1 
HETATM 3684 O O   . HOH B 2 .   ? -15.89982 -0.80917  -27.02073 1.000 36.37465 ? 1118 HOH A O   1 
HETATM 3685 O O   . HOH B 2 .   ? -35.44371 -38.21229 -17.32116 1.000 39.05259 ? 1119 HOH A O   1 
HETATM 3686 O O   . HOH B 2 .   ? -16.17525 11.44121  0.42534   1.000 33.49144 ? 1120 HOH A O   1 
HETATM 3687 O O   . HOH B 2 .   ? -29.42835 19.57428  -13.72625 1.000 39.78853 ? 1121 HOH A O   1 
HETATM 3688 O O   . HOH B 2 .   ? -22.53135 -19.61391 -8.59971  1.000 42.30964 ? 1122 HOH A O   1 
HETATM 3689 O O   . HOH B 2 .   ? -20.10165 9.87648   -13.57450 1.000 38.04587 ? 1123 HOH A O   1 
HETATM 3690 O O   . HOH B 2 .   ? -40.37633 -35.92923 -21.23581 1.000 51.55397 ? 1124 HOH A O   1 
HETATM 3691 O O   . HOH B 2 .   ? -25.35080 12.46717  -11.82726 1.000 24.41644 ? 1125 HOH A O   1 
HETATM 3692 O O   . HOH B 2 .   ? -9.41531  2.05749   2.97105   1.000 46.92396 ? 1126 HOH A O   1 
HETATM 3693 O O   . HOH B 2 .   ? -18.177   8.314     -1.612    1.000 27.64246 ? 1127 HOH A O   1 
HETATM 3694 O O   . HOH B 2 .   ? -28.89158 -9.94137  -20.89627 1.000 34.96517 ? 1128 HOH A O   1 
HETATM 3695 O O   . HOH B 2 .   ? -25.63369 -13.30178 2.28928   1.000 39.99376 ? 1129 HOH A O   1 
HETATM 3696 O O   . HOH B 2 .   ? 0.48143   25.10242  12.40480  1.000 41.21202 ? 1130 HOH A O   1 
HETATM 3697 O O   . HOH B 2 .   ? -8.625    -9.577    -12.620   1.000 34.29048 ? 1131 HOH A O   1 
HETATM 3698 O O   . HOH B 2 .   ? -22.51154 -22.19081 -9.78891  1.000 35.68090 ? 1132 HOH A O   1 
HETATM 3699 O O   . HOH B 2 .   ? -43.74637 -23.62239 -25.08729 1.000 42.01091 ? 1133 HOH A O   1 
HETATM 3700 O O   . HOH B 2 .   ? -18.12326 -0.33673  -27.30625 1.000 36.86693 ? 1134 HOH A O   1 
HETATM 3701 O O   . HOH B 2 .   ? -29.609   7.104     5.163     1.000 41.50158 ? 1135 HOH A O   1 
HETATM 3702 O O   . HOH B 2 .   ? -26.13334 15.18581  -11.51839 1.000 31.44098 ? 1136 HOH A O   1 
HETATM 3703 O O   . HOH B 2 .   ? -15.36321 21.70516  -37.28741 1.000 38.16490 ? 1137 HOH A O   1 
HETATM 3704 O O   . HOH B 2 .   ? -23.65927 -22.85836 -6.02553  1.000 36.08418 ? 1138 HOH A O   1 
HETATM 3705 O O   . HOH B 2 .   ? -3.59130  4.82032   -16.86750 1.000 45.66780 ? 1139 HOH A O   1 
HETATM 3706 O O   . HOH B 2 .   ? -7.07178  4.76342   -29.49801 1.000 45.96084 ? 1140 HOH A O   1 
HETATM 3707 O O   . HOH B 2 .   ? -27.29354 17.27473  -12.84028 1.000 37.51011 ? 1141 HOH A O   1 
HETATM 3708 O O   . HOH B 2 .   ? -40.47042 -35.25692 -34.83540 1.000 38.35545 ? 1142 HOH A O   1 
HETATM 3709 O O   . HOH B 2 .   ? -18.063   10.930    -1.540    1.000 29.71103 ? 1143 HOH A O   1 
HETATM 3710 O O   . HOH B 2 .   ? -5.59427  9.17999   2.80211   1.000 33.31748 ? 1144 HOH A O   1 
HETATM 3711 O O   . HOH B 2 .   ? -27.04183 22.13334  -41.82702 1.000 40.39997 ? 1145 HOH A O   1 
HETATM 3712 O O   . HOH B 2 .   ? -37.70075 -36.92482 -38.16417 1.000 38.62401 ? 1146 HOH A O   1 
HETATM 3713 O O   . HOH B 2 .   ? -35.52366 -3.71037  -3.73971  1.000 42.23441 ? 1147 HOH A O   1 
HETATM 3714 O O   . HOH B 2 .   ? 4.19850   25.59714  -19.55171 1.000 42.74274 ? 1148 HOH A O   1 
HETATM 3715 O O   . HOH B 2 .   ? 13.77979  12.94081  2.44811   1.000 31.89710 ? 1149 HOH A O   1 
HETATM 3716 O O   . HOH B 2 .   ? -9.75565  9.53376   1.67600   1.000 39.64943 ? 1150 HOH A O   1 
HETATM 3717 O O   . HOH B 2 .   ? -28.060   3.959     -28.306   1.000 42.38719 ? 1151 HOH A O   1 
HETATM 3718 O O   . HOH B 2 .   ? -8.615    8.654     -39.145   1.000 44.99980 ? 1152 HOH A O   1 
HETATM 3719 O O   . HOH B 2 .   ? -28.23403 15.87582  -9.90944  1.000 37.79389 ? 1153 HOH A O   1 
HETATM 3720 O O   . HOH B 2 .   ? -40.31573 -36.54045 -36.38968 1.000 35.33291 ? 1154 HOH A O   1 
HETATM 3721 O O   . HOH B 2 .   ? 8.86923   33.88872  -13.70445 1.000 43.78546 ? 1155 HOH A O   1 
HETATM 3722 O O   . HOH B 2 .   ? 1.44498   27.38823  -22.15687 1.000 45.68648 ? 1156 HOH A O   1 
HETATM 3723 O O   . HOH B 2 .   ? -13.98831 -19.72162 -30.56307 1.000 46.16769 ? 1157 HOH A O   1 
HETATM 3724 O O   . HOH B 2 .   ? -19.78532 -23.10195 -8.93216  1.000 44.80123 ? 1158 HOH A O   1 
# 
