data_9DQR
# 
_entry.id   9DQR 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQR         pdb_00009dqr 10.2210/pdb9dqr/pdb 
WWPDB D_1000288600 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQR 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wchang6@ncsu.edu 
_pdbx_contact_author.name_first         Wei-chen 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2341-9846 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, Y.-C.' 1 ? 
'Chang, W.-C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            147 
_citation.language                  ? 
_citation.page_first                6162 
_citation.page_last                 6170 
_citation.title                     
;Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c17741 
_citation.pdbx_database_id_PubMed   39901767 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, Y.C.'   1  ? 
primary 'Li, X.'        2  ? 
primary 'Cha, L.'       3  ? 
primary 'Paris, J.C.'   4  ? 
primary 'Michael, C.'   5  ? 
primary 'Ushimaru, R.'  6  ? 
primary 'Ogasawara, Y.' 7  ? 
primary 'Abe, I.'       8  ? 
primary 'Guo, Y.'       9  ? 
primary 'Chang, W.C.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '2OG-Fe dioxygenase family protein' 29345.768 2   ? ? ? ? 
2 non-polymer syn 'SUCCINIC ACID'                     118.088   2   ? ? ? ? 
3 non-polymer syn 'oxovanadium(2+)'                   66.941    2   ? ? ? ? 
4 water       nat water                               18.015    349 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'SUCCINIC ACID'   SIN 
3 'oxovanadium(2+)' VVO 
4 water             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLN n 
1 3   THR n 
1 4   GLU n 
1 5   ALA n 
1 6   ARG n 
1 7   GLU n 
1 8   GLU n 
1 9   LEU n 
1 10  ARG n 
1 11  ALA n 
1 12  ASN n 
1 13  GLY n 
1 14  TYR n 
1 15  SER n 
1 16  LEU n 
1 17  LEU n 
1 18  PRO n 
1 19  ALA n 
1 20  ASP n 
1 21  ARG n 
1 22  LEU n 
1 23  VAL n 
1 24  ILE n 
1 25  ASP n 
1 26  ALA n 
1 27  GLU n 
1 28  LEU n 
1 29  ARG n 
1 30  GLN n 
1 31  HIS n 
1 32  VAL n 
1 33  LYS n 
1 34  GLU n 
1 35  LEU n 
1 36  ALA n 
1 37  ALA n 
1 38  GLU n 
1 39  TRP n 
1 40  GLU n 
1 41  ASN n 
1 42  LEU n 
1 43  GLU n 
1 44  THR n 
1 45  ASP n 
1 46  ARG n 
1 47  TYR n 
1 48  LEU n 
1 49  LYS n 
1 50  GLY n 
1 51  GLY n 
1 52  SER n 
1 53  ARG n 
1 54  PHE n 
1 55  ARG n 
1 56  GLU n 
1 57  ARG n 
1 58  ALA n 
1 59  TYR n 
1 60  ASP n 
1 61  ARG n 
1 62  PHE n 
1 63  PHE n 
1 64  PHE n 
1 65  VAL n 
1 66  PRO n 
1 67  ARG n 
1 68  THR n 
1 69  GLY n 
1 70  GLU n 
1 71  VAL n 
1 72  ARG n 
1 73  LEU n 
1 74  ARG n 
1 75  PRO n 
1 76  HIS n 
1 77  ARG n 
1 78  PRO n 
1 79  TYR n 
1 80  PHE n 
1 81  GLN n 
1 82  SER n 
1 83  MET n 
1 84  ASN n 
1 85  ALA n 
1 86  ASN n 
1 87  ASP n 
1 88  TYR n 
1 89  ALA n 
1 90  GLY n 
1 91  GLY n 
1 92  ILE n 
1 93  ASP n 
1 94  ARG n 
1 95  ASP n 
1 96  VAL n 
1 97  ALA n 
1 98  PRO n 
1 99  LEU n 
1 100 SER n 
1 101 ARG n 
1 102 THR n 
1 103 THR n 
1 104 LEU n 
1 105 ALA n 
1 106 ASN n 
1 107 PRO n 
1 108 LEU n 
1 109 LEU n 
1 110 THR n 
1 111 ARG n 
1 112 LEU n 
1 113 LEU n 
1 114 ARG n 
1 115 ALA n 
1 116 ASP n 
1 117 PHE n 
1 118 GLU n 
1 119 ASN n 
1 120 PHE n 
1 121 PRO n 
1 122 VAL n 
1 123 PRO n 
1 124 GLU n 
1 125 GLU n 
1 126 SER n 
1 127 TRP n 
1 128 LEU n 
1 129 ASP n 
1 130 ASP n 
1 131 PRO n 
1 132 TRP n 
1 133 ASP n 
1 134 VAL n 
1 135 GLN n 
1 136 CYS n 
1 137 HIS n 
1 138 GLN n 
1 139 PHE n 
1 140 ARG n 
1 141 ILE n 
1 142 ILE n 
1 143 SER n 
1 144 THR n 
1 145 PRO n 
1 146 ASP n 
1 147 GLU n 
1 148 THR n 
1 149 GLY n 
1 150 GLU n 
1 151 PRO n 
1 152 THR n 
1 153 PRO n 
1 154 GLU n 
1 155 GLY n 
1 156 PRO n 
1 157 HIS n 
1 158 ARG n 
1 159 ASP n 
1 160 GLU n 
1 161 VAL n 
1 162 ASP n 
1 163 PHE n 
1 164 GLY n 
1 165 VAL n 
1 166 ILE n 
1 167 HIS n 
1 168 LEU n 
1 169 MET n 
1 170 GLY n 
1 171 ARG n 
1 172 PHE n 
1 173 ASN n 
1 174 ALA n 
1 175 ALA n 
1 176 GLY n 
1 177 GLY n 
1 178 GLU n 
1 179 SER n 
1 180 GLN n 
1 181 VAL n 
1 182 TYR n 
1 183 SER n 
1 184 LEU n 
1 185 GLU n 
1 186 ARG n 
1 187 GLU n 
1 188 LEU n 
1 189 VAL n 
1 190 ALA n 
1 191 GLU n 
1 192 PHE n 
1 193 CYS n 
1 194 LEU n 
1 195 THR n 
1 196 GLU n 
1 197 GLN n 
1 198 MET n 
1 199 ASP n 
1 200 THR n 
1 201 MET n 
1 202 PHE n 
1 203 TRP n 
1 204 SER n 
1 205 ASP n 
1 206 GLY n 
1 207 GLN n 
1 208 ILE n 
1 209 LEU n 
1 210 HIS n 
1 211 ALA n 
1 212 VAL n 
1 213 ARG n 
1 214 PRO n 
1 215 ILE n 
1 216 HIS n 
1 217 PRO n 
1 218 VAL n 
1 219 ASP n 
1 220 PRO n 
1 221 THR n 
1 222 LYS n 
1 223 ALA n 
1 224 ALA n 
1 225 VAL n 
1 226 ARG n 
1 227 ASP n 
1 228 VAL n 
1 229 LEU n 
1 230 ILE n 
1 231 MET n 
1 232 GLY n 
1 233 TYR n 
1 234 LYS n 
1 235 HIS n 
1 236 GLU n 
1 237 PRO n 
1 238 GLU n 
1 239 LEU n 
1 240 ARG n 
1 241 ARG n 
1 242 GLU n 
1 243 GLU n 
1 244 GLN n 
1 245 GLY n 
1 246 ALA n 
1 247 ALA n 
1 248 HIS n 
1 249 HIS n 
1 250 HIS n 
1 251 HIS n 
1 252 HIS n 
1 253 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   253 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 EDD96_7010 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp. Ag109_G2-6' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2485154 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE          ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE         ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE         ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE           ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE            ? 'C3 H7 N O3'     105.093 
SIN non-polymer         . 'SUCCINIC ACID'   ? 'C4 H6 O4'       118.088 
THR 'L-peptide linking' y THREONINE         ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN        ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE          ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ? 'C5 H11 N O2'    117.146 
VVO non-polymer         . 'oxovanadium(2+)' ? 'O V 2'          66.941  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLN 2   2   2   GLN GLN A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ALA 5   5   5   ALA ALA A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   GLU 8   8   8   GLU GLU A . n 
A 1 9   LEU 9   9   9   LEU LEU A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  ASN 12  12  12  ASN ASN A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  ASP 20  20  20  ASP ASP A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  VAL 23  23  23  VAL VAL A . n 
A 1 24  ILE 24  24  24  ILE ALA A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  HIS 31  31  31  HIS HIS A . n 
A 1 32  VAL 32  32  32  VAL VAL A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  GLU 38  38  38  GLU GLU A . n 
A 1 39  TRP 39  39  39  TRP TRP A . n 
A 1 40  GLU 40  40  40  GLU GLU A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  ARG 46  46  ?   ?   ?   A . n 
A 1 47  TYR 47  47  ?   ?   ?   A . n 
A 1 48  LEU 48  48  ?   ?   ?   A . n 
A 1 49  LYS 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  GLY 51  51  ?   ?   ?   A . n 
A 1 52  SER 52  52  ?   ?   ?   A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  ARG 55  55  55  ARG ARG A . n 
A 1 56  GLU 56  56  56  GLU GLU A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  PHE 62  62  62  PHE PHE A . n 
A 1 63  PHE 63  63  63  PHE PHE A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  VAL 71  71  71  VAL VAL A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  LEU 73  73  73  LEU LEU A . n 
A 1 74  ARG 74  74  74  ARG ARG A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  HIS 76  76  76  HIS HIS A . n 
A 1 77  ARG 77  77  77  ARG ARG A . n 
A 1 78  PRO 78  78  78  PRO PRO A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  GLN 81  81  81  GLN GLN A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  ALA 89  89  89  ALA ALA A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ARG 94  94  94  ARG ARG A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  PRO 98  98  98  PRO PRO A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 ARG 101 101 101 ARG ARG A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 THR 110 110 110 THR THR A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 GLU 118 118 118 GLU GLU A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 PHE 120 120 120 PHE PHE A . n 
A 1 121 PRO 121 121 121 PRO PRO A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 GLU 124 124 124 GLU GLU A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 SER 126 126 126 SER SER A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 PRO 131 131 131 PRO PRO A . n 
A 1 132 TRP 132 132 132 TRP TRP A . n 
A 1 133 ASP 133 133 133 ASP ASP A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 CYS 136 136 136 CYS CYS A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 GLU 147 147 ?   ?   ?   A . n 
A 1 148 THR 148 148 ?   ?   ?   A . n 
A 1 149 GLY 149 149 ?   ?   ?   A . n 
A 1 150 GLU 150 150 ?   ?   ?   A . n 
A 1 151 PRO 151 151 ?   ?   ?   A . n 
A 1 152 THR 152 152 ?   ?   ?   A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 GLY 155 155 155 GLY GLY A . n 
A 1 156 PRO 156 156 156 PRO PRO A . n 
A 1 157 HIS 157 157 157 HIS HIS A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 PHE 163 163 163 PHE PHE A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 MET 169 169 169 MET MET A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 ASN 173 173 173 ASN ASN A . n 
A 1 174 ALA 174 174 174 ALA ALA A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 GLN 197 197 197 GLN GLN A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 ASP 199 199 199 ASP ASP A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 MET 201 201 201 MET MET A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 TRP 203 203 203 TRP TRP A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 GLN 207 207 207 GLN GLN A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 HIS 210 210 210 HIS HIS A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ARG 213 213 213 ARG ARG A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 HIS 216 216 216 HIS HIS A . n 
A 1 217 PRO 217 217 217 PRO PRO A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 PRO 220 220 220 PRO PRO A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 VAL 225 225 225 VAL VAL A . n 
A 1 226 ARG 226 226 226 ARG ARG A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 ILE 230 230 230 ILE ILE A . n 
A 1 231 MET 231 231 231 MET MET A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 TYR 233 233 233 TYR TYR A . n 
A 1 234 LYS 234 234 234 LYS LYS A . n 
A 1 235 HIS 235 235 235 HIS HIS A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 ARG 241 241 241 ARG ARG A . n 
A 1 242 GLU 242 242 242 GLU GLU A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 GLY 245 245 ?   ?   ?   A . n 
A 1 246 ALA 246 246 ?   ?   ?   A . n 
A 1 247 ALA 247 247 ?   ?   ?   A . n 
A 1 248 HIS 248 248 ?   ?   ?   A . n 
A 1 249 HIS 249 249 ?   ?   ?   A . n 
A 1 250 HIS 250 250 ?   ?   ?   A . n 
A 1 251 HIS 251 251 ?   ?   ?   A . n 
A 1 252 HIS 252 252 ?   ?   ?   A . n 
A 1 253 HIS 253 253 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLN 2   2   ?   ?   ?   B . n 
B 1 3   THR 3   3   3   THR THR B . n 
B 1 4   GLU 4   4   4   GLU GLU B . n 
B 1 5   ALA 5   5   5   ALA ALA B . n 
B 1 6   ARG 6   6   6   ARG ARG B . n 
B 1 7   GLU 7   7   7   GLU GLU B . n 
B 1 8   GLU 8   8   8   GLU GLU B . n 
B 1 9   LEU 9   9   9   LEU LEU B . n 
B 1 10  ARG 10  10  10  ARG ARG B . n 
B 1 11  ALA 11  11  11  ALA ALA B . n 
B 1 12  ASN 12  12  12  ASN ASN B . n 
B 1 13  GLY 13  13  13  GLY GLY B . n 
B 1 14  TYR 14  14  14  TYR TYR B . n 
B 1 15  SER 15  15  15  SER SER B . n 
B 1 16  LEU 16  16  16  LEU LEU B . n 
B 1 17  LEU 17  17  17  LEU LEU B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  ALA 19  19  19  ALA ALA B . n 
B 1 20  ASP 20  20  20  ASP ASP B . n 
B 1 21  ARG 21  21  21  ARG ARG B . n 
B 1 22  LEU 22  22  22  LEU LEU B . n 
B 1 23  VAL 23  23  23  VAL VAL B . n 
B 1 24  ILE 24  24  24  ILE ALA B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ALA 26  26  26  ALA ALA B . n 
B 1 27  GLU 27  27  27  GLU GLU B . n 
B 1 28  LEU 28  28  28  LEU LEU B . n 
B 1 29  ARG 29  29  29  ARG ARG B . n 
B 1 30  GLN 30  30  30  GLN GLN B . n 
B 1 31  HIS 31  31  31  HIS HIS B . n 
B 1 32  VAL 32  32  32  VAL VAL B . n 
B 1 33  LYS 33  33  33  LYS LYS B . n 
B 1 34  GLU 34  34  34  GLU GLU B . n 
B 1 35  LEU 35  35  35  LEU LEU B . n 
B 1 36  ALA 36  36  36  ALA ALA B . n 
B 1 37  ALA 37  37  37  ALA ALA B . n 
B 1 38  GLU 38  38  38  GLU GLU B . n 
B 1 39  TRP 39  39  39  TRP TRP B . n 
B 1 40  GLU 40  40  40  GLU GLU B . n 
B 1 41  ASN 41  41  41  ASN ASN B . n 
B 1 42  LEU 42  42  42  LEU LEU B . n 
B 1 43  GLU 43  43  43  GLU GLU B . n 
B 1 44  THR 44  44  44  THR THR B . n 
B 1 45  ASP 45  45  45  ASP ASP B . n 
B 1 46  ARG 46  46  46  ARG ARG B . n 
B 1 47  TYR 47  47  ?   ?   ?   B . n 
B 1 48  LEU 48  48  ?   ?   ?   B . n 
B 1 49  LYS 49  49  ?   ?   ?   B . n 
B 1 50  GLY 50  50  ?   ?   ?   B . n 
B 1 51  GLY 51  51  51  GLY GLY B . n 
B 1 52  SER 52  52  52  SER SER B . n 
B 1 53  ARG 53  53  53  ARG ARG B . n 
B 1 54  PHE 54  54  54  PHE PHE B . n 
B 1 55  ARG 55  55  55  ARG ARG B . n 
B 1 56  GLU 56  56  56  GLU GLU B . n 
B 1 57  ARG 57  57  57  ARG ARG B . n 
B 1 58  ALA 58  58  58  ALA ALA B . n 
B 1 59  TYR 59  59  59  TYR TYR B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  ARG 61  61  61  ARG ARG B . n 
B 1 62  PHE 62  62  62  PHE PHE B . n 
B 1 63  PHE 63  63  63  PHE PHE B . n 
B 1 64  PHE 64  64  64  PHE PHE B . n 
B 1 65  VAL 65  65  65  VAL VAL B . n 
B 1 66  PRO 66  66  66  PRO PRO B . n 
B 1 67  ARG 67  67  67  ARG ARG B . n 
B 1 68  THR 68  68  68  THR THR B . n 
B 1 69  GLY 69  69  69  GLY GLY B . n 
B 1 70  GLU 70  70  70  GLU GLU B . n 
B 1 71  VAL 71  71  71  VAL VAL B . n 
B 1 72  ARG 72  72  72  ARG ARG B . n 
B 1 73  LEU 73  73  73  LEU LEU B . n 
B 1 74  ARG 74  74  74  ARG ARG B . n 
B 1 75  PRO 75  75  75  PRO PRO B . n 
B 1 76  HIS 76  76  76  HIS HIS B . n 
B 1 77  ARG 77  77  77  ARG ARG B . n 
B 1 78  PRO 78  78  78  PRO PRO B . n 
B 1 79  TYR 79  79  79  TYR TYR B . n 
B 1 80  PHE 80  80  80  PHE PHE B . n 
B 1 81  GLN 81  81  81  GLN GLN B . n 
B 1 82  SER 82  82  82  SER SER B . n 
B 1 83  MET 83  83  83  MET MET B . n 
B 1 84  ASN 84  84  84  ASN ASN B . n 
B 1 85  ALA 85  85  85  ALA ALA B . n 
B 1 86  ASN 86  86  86  ASN ASN B . n 
B 1 87  ASP 87  87  87  ASP ASP B . n 
B 1 88  TYR 88  88  ?   ?   ?   B . n 
B 1 89  ALA 89  89  ?   ?   ?   B . n 
B 1 90  GLY 90  90  ?   ?   ?   B . n 
B 1 91  GLY 91  91  ?   ?   ?   B . n 
B 1 92  ILE 92  92  ?   ?   ?   B . n 
B 1 93  ASP 93  93  93  ASP ALA B . n 
B 1 94  ARG 94  94  94  ARG ALA B . n 
B 1 95  ASP 95  95  95  ASP ALA B . n 
B 1 96  VAL 96  96  96  VAL ALA B . n 
B 1 97  ALA 97  97  97  ALA ALA B . n 
B 1 98  PRO 98  98  98  PRO PRO B . n 
B 1 99  LEU 99  99  99  LEU LEU B . n 
B 1 100 SER 100 100 100 SER SER B . n 
B 1 101 ARG 101 101 101 ARG ARG B . n 
B 1 102 THR 102 102 102 THR THR B . n 
B 1 103 THR 103 103 103 THR THR B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 ALA 105 105 105 ALA ALA B . n 
B 1 106 ASN 106 106 106 ASN ASN B . n 
B 1 107 PRO 107 107 107 PRO PRO B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 LEU 109 109 109 LEU LEU B . n 
B 1 110 THR 110 110 110 THR THR B . n 
B 1 111 ARG 111 111 111 ARG ARG B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 LEU 113 113 113 LEU LEU B . n 
B 1 114 ARG 114 114 114 ARG ARG B . n 
B 1 115 ALA 115 115 115 ALA ALA B . n 
B 1 116 ASP 116 116 116 ASP ASP B . n 
B 1 117 PHE 117 117 117 PHE PHE B . n 
B 1 118 GLU 118 118 118 GLU GLU B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 PHE 120 120 120 PHE PHE B . n 
B 1 121 PRO 121 121 121 PRO PRO B . n 
B 1 122 VAL 122 122 122 VAL VAL B . n 
B 1 123 PRO 123 123 123 PRO PRO B . n 
B 1 124 GLU 124 124 124 GLU GLU B . n 
B 1 125 GLU 125 125 125 GLU GLU B . n 
B 1 126 SER 126 126 126 SER SER B . n 
B 1 127 TRP 127 127 127 TRP TRP B . n 
B 1 128 LEU 128 128 128 LEU LEU B . n 
B 1 129 ASP 129 129 129 ASP ASP B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 PRO 131 131 131 PRO PRO B . n 
B 1 132 TRP 132 132 132 TRP TRP B . n 
B 1 133 ASP 133 133 133 ASP ASP B . n 
B 1 134 VAL 134 134 134 VAL VAL B . n 
B 1 135 GLN 135 135 135 GLN GLN B . n 
B 1 136 CYS 136 136 136 CYS CYS B . n 
B 1 137 HIS 137 137 137 HIS HIS B . n 
B 1 138 GLN 138 138 138 GLN GLN B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 ARG 140 140 140 ARG ARG B . n 
B 1 141 ILE 141 141 141 ILE ILE B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 SER 143 143 143 SER SER B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 PRO 145 145 145 PRO PRO B . n 
B 1 146 ASP 146 146 146 ASP ASP B . n 
B 1 147 GLU 147 147 147 GLU GLU B . n 
B 1 148 THR 148 148 ?   ?   ?   B . n 
B 1 149 GLY 149 149 ?   ?   ?   B . n 
B 1 150 GLU 150 150 ?   ?   ?   B . n 
B 1 151 PRO 151 151 ?   ?   ?   B . n 
B 1 152 THR 152 152 ?   ?   ?   B . n 
B 1 153 PRO 153 153 ?   ?   ?   B . n 
B 1 154 GLU 154 154 154 GLU GLU B . n 
B 1 155 GLY 155 155 155 GLY GLY B . n 
B 1 156 PRO 156 156 156 PRO PRO B . n 
B 1 157 HIS 157 157 157 HIS HIS B . n 
B 1 158 ARG 158 158 158 ARG ARG B . n 
B 1 159 ASP 159 159 159 ASP ASP B . n 
B 1 160 GLU 160 160 160 GLU GLU B . n 
B 1 161 VAL 161 161 161 VAL VAL B . n 
B 1 162 ASP 162 162 162 ASP ASP B . n 
B 1 163 PHE 163 163 163 PHE PHE B . n 
B 1 164 GLY 164 164 164 GLY GLY B . n 
B 1 165 VAL 165 165 165 VAL VAL B . n 
B 1 166 ILE 166 166 166 ILE ILE B . n 
B 1 167 HIS 167 167 167 HIS HIS B . n 
B 1 168 LEU 168 168 168 LEU LEU B . n 
B 1 169 MET 169 169 169 MET MET B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 ARG 171 171 171 ARG ARG B . n 
B 1 172 PHE 172 172 172 PHE PHE B . n 
B 1 173 ASN 173 173 173 ASN ASN B . n 
B 1 174 ALA 174 174 174 ALA ALA B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 GLY 176 176 176 GLY GLY B . n 
B 1 177 GLY 177 177 177 GLY GLY B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 SER 179 179 179 SER SER B . n 
B 1 180 GLN 180 180 180 GLN GLN B . n 
B 1 181 VAL 181 181 181 VAL VAL B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 SER 183 183 183 SER SER B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 ARG 186 186 186 ARG ARG B . n 
B 1 187 GLU 187 187 187 GLU GLU B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 VAL 189 189 189 VAL VAL B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 GLU 191 191 191 GLU GLU B . n 
B 1 192 PHE 192 192 192 PHE PHE B . n 
B 1 193 CYS 193 193 193 CYS CYS B . n 
B 1 194 LEU 194 194 194 LEU LEU B . n 
B 1 195 THR 195 195 195 THR THR B . n 
B 1 196 GLU 196 196 196 GLU GLU B . n 
B 1 197 GLN 197 197 197 GLN GLN B . n 
B 1 198 MET 198 198 198 MET MET B . n 
B 1 199 ASP 199 199 199 ASP ASP B . n 
B 1 200 THR 200 200 200 THR THR B . n 
B 1 201 MET 201 201 201 MET MET B . n 
B 1 202 PHE 202 202 202 PHE PHE B . n 
B 1 203 TRP 203 203 203 TRP TRP B . n 
B 1 204 SER 204 204 204 SER SER B . n 
B 1 205 ASP 205 205 205 ASP ASP B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 GLN 207 207 207 GLN GLN B . n 
B 1 208 ILE 208 208 208 ILE ILE B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 HIS 210 210 210 HIS HIS B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ARG 213 213 213 ARG ARG B . n 
B 1 214 PRO 214 214 214 PRO PRO B . n 
B 1 215 ILE 215 215 215 ILE ILE B . n 
B 1 216 HIS 216 216 216 HIS HIS B . n 
B 1 217 PRO 217 217 217 PRO PRO B . n 
B 1 218 VAL 218 218 218 VAL VAL B . n 
B 1 219 ASP 219 219 219 ASP ASP B . n 
B 1 220 PRO 220 220 220 PRO PRO B . n 
B 1 221 THR 221 221 221 THR THR B . n 
B 1 222 LYS 222 222 222 LYS LYS B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 VAL 225 225 225 VAL VAL B . n 
B 1 226 ARG 226 226 226 ARG ARG B . n 
B 1 227 ASP 227 227 227 ASP ASP B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 ILE 230 230 230 ILE ILE B . n 
B 1 231 MET 231 231 231 MET MET B . n 
B 1 232 GLY 232 232 232 GLY GLY B . n 
B 1 233 TYR 233 233 233 TYR TYR B . n 
B 1 234 LYS 234 234 234 LYS LYS B . n 
B 1 235 HIS 235 235 235 HIS HIS B . n 
B 1 236 GLU 236 236 236 GLU GLU B . n 
B 1 237 PRO 237 237 237 PRO PRO B . n 
B 1 238 GLU 238 238 238 GLU GLU B . n 
B 1 239 LEU 239 239 239 LEU LEU B . n 
B 1 240 ARG 240 240 240 ARG ARG B . n 
B 1 241 ARG 241 241 241 ARG ARG B . n 
B 1 242 GLU 242 242 242 GLU GLU B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLN 244 244 ?   ?   ?   B . n 
B 1 245 GLY 245 245 ?   ?   ?   B . n 
B 1 246 ALA 246 246 ?   ?   ?   B . n 
B 1 247 ALA 247 247 ?   ?   ?   B . n 
B 1 248 HIS 248 248 ?   ?   ?   B . n 
B 1 249 HIS 249 249 ?   ?   ?   B . n 
B 1 250 HIS 250 250 ?   ?   ?   B . n 
B 1 251 HIS 251 251 ?   ?   ?   B . n 
B 1 252 HIS 252 252 ?   ?   ?   B . n 
B 1 253 HIS 253 253 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 SIN ? ? SIN ? ? 'SUBJECT OF INVESTIGATION' ? 
2 VVO ? ? VVO ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 SIN 1   301 302  SIN SIN A . 
D 3 VVO 1   302 303  VVO VVO A . 
E 2 SIN 1   301 302  SIN SIN B . 
F 3 VVO 1   302 303  VVO VVO B . 
G 4 HOH 1   401 742  HOH HOH A . 
G 4 HOH 2   402 405  HOH HOH A . 
G 4 HOH 3   403 74   HOH HOH A . 
G 4 HOH 4   404 791  HOH HOH A . 
G 4 HOH 5   405 789  HOH HOH A . 
G 4 HOH 6   406 34   HOH HOH A . 
G 4 HOH 7   407 43   HOH HOH A . 
G 4 HOH 8   408 338  HOH HOH A . 
G 4 HOH 9   409 1113 HOH HOH A . 
G 4 HOH 10  410 362  HOH HOH A . 
G 4 HOH 11  411 1043 HOH HOH A . 
G 4 HOH 12  412 82   HOH HOH A . 
G 4 HOH 13  413 582  HOH HOH A . 
G 4 HOH 14  414 1    HOH HOH A . 
G 4 HOH 15  415 472  HOH HOH A . 
G 4 HOH 16  416 157  HOH HOH A . 
G 4 HOH 17  417 293  HOH HOH A . 
G 4 HOH 18  418 17   HOH HOH A . 
G 4 HOH 19  419 16   HOH HOH A . 
G 4 HOH 20  420 156  HOH HOH A . 
G 4 HOH 21  421 36   HOH HOH A . 
G 4 HOH 22  422 182  HOH HOH A . 
G 4 HOH 23  423 143  HOH HOH A . 
G 4 HOH 24  424 53   HOH HOH A . 
G 4 HOH 25  425 938  HOH HOH A . 
G 4 HOH 26  426 25   HOH HOH A . 
G 4 HOH 27  427 98   HOH HOH A . 
G 4 HOH 28  428 805  HOH HOH A . 
G 4 HOH 29  429 121  HOH HOH A . 
G 4 HOH 30  430 796  HOH HOH A . 
G 4 HOH 31  431 55   HOH HOH A . 
G 4 HOH 32  432 15   HOH HOH A . 
G 4 HOH 33  433 212  HOH HOH A . 
G 4 HOH 34  434 147  HOH HOH A . 
G 4 HOH 35  435 2    HOH HOH A . 
G 4 HOH 36  436 14   HOH HOH A . 
G 4 HOH 37  437 137  HOH HOH A . 
G 4 HOH 38  438 22   HOH HOH A . 
G 4 HOH 39  439 5    HOH HOH A . 
G 4 HOH 40  440 9    HOH HOH A . 
G 4 HOH 41  441 89   HOH HOH A . 
G 4 HOH 42  442 958  HOH HOH A . 
G 4 HOH 43  443 37   HOH HOH A . 
G 4 HOH 44  444 3    HOH HOH A . 
G 4 HOH 45  445 857  HOH HOH A . 
G 4 HOH 46  446 139  HOH HOH A . 
G 4 HOH 47  447 81   HOH HOH A . 
G 4 HOH 48  448 19   HOH HOH A . 
G 4 HOH 49  449 24   HOH HOH A . 
G 4 HOH 50  450 136  HOH HOH A . 
G 4 HOH 51  451 35   HOH HOH A . 
G 4 HOH 52  452 88   HOH HOH A . 
G 4 HOH 53  453 13   HOH HOH A . 
G 4 HOH 54  454 33   HOH HOH A . 
G 4 HOH 55  455 256  HOH HOH A . 
G 4 HOH 56  456 47   HOH HOH A . 
G 4 HOH 57  457 837  HOH HOH A . 
G 4 HOH 58  458 122  HOH HOH A . 
G 4 HOH 59  459 70   HOH HOH A . 
G 4 HOH 60  460 550  HOH HOH A . 
G 4 HOH 61  461 42   HOH HOH A . 
G 4 HOH 62  462 577  HOH HOH A . 
G 4 HOH 63  463 238  HOH HOH A . 
G 4 HOH 64  464 18   HOH HOH A . 
G 4 HOH 65  465 251  HOH HOH A . 
G 4 HOH 66  466 269  HOH HOH A . 
G 4 HOH 67  467 219  HOH HOH A . 
G 4 HOH 68  468 114  HOH HOH A . 
G 4 HOH 69  469 23   HOH HOH A . 
G 4 HOH 70  470 109  HOH HOH A . 
G 4 HOH 71  471 790  HOH HOH A . 
G 4 HOH 72  472 129  HOH HOH A . 
G 4 HOH 73  473 8    HOH HOH A . 
G 4 HOH 74  474 72   HOH HOH A . 
G 4 HOH 75  475 21   HOH HOH A . 
G 4 HOH 76  476 96   HOH HOH A . 
G 4 HOH 77  477 91   HOH HOH A . 
G 4 HOH 78  478 192  HOH HOH A . 
G 4 HOH 79  479 29   HOH HOH A . 
G 4 HOH 80  480 73   HOH HOH A . 
G 4 HOH 81  481 86   HOH HOH A . 
G 4 HOH 82  482 459  HOH HOH A . 
G 4 HOH 83  483 723  HOH HOH A . 
G 4 HOH 84  484 420  HOH HOH A . 
G 4 HOH 85  485 11   HOH HOH A . 
G 4 HOH 86  486 56   HOH HOH A . 
G 4 HOH 87  487 45   HOH HOH A . 
G 4 HOH 88  488 46   HOH HOH A . 
G 4 HOH 89  489 75   HOH HOH A . 
G 4 HOH 90  490 77   HOH HOH A . 
G 4 HOH 91  491 6    HOH HOH A . 
G 4 HOH 92  492 154  HOH HOH A . 
G 4 HOH 93  493 179  HOH HOH A . 
G 4 HOH 94  494 575  HOH HOH A . 
G 4 HOH 95  495 303  HOH HOH A . 
G 4 HOH 96  496 61   HOH HOH A . 
G 4 HOH 97  497 67   HOH HOH A . 
G 4 HOH 98  498 48   HOH HOH A . 
G 4 HOH 99  499 118  HOH HOH A . 
G 4 HOH 100 500 551  HOH HOH A . 
G 4 HOH 101 501 163  HOH HOH A . 
G 4 HOH 102 502 398  HOH HOH A . 
G 4 HOH 103 503 498  HOH HOH A . 
G 4 HOH 104 504 207  HOH HOH A . 
G 4 HOH 105 505 110  HOH HOH A . 
G 4 HOH 106 506 859  HOH HOH A . 
G 4 HOH 107 507 969  HOH HOH A . 
G 4 HOH 108 508 548  HOH HOH A . 
G 4 HOH 109 509 30   HOH HOH A . 
G 4 HOH 110 510 54   HOH HOH A . 
G 4 HOH 111 511 31   HOH HOH A . 
G 4 HOH 112 512 650  HOH HOH A . 
G 4 HOH 113 513 1015 HOH HOH A . 
G 4 HOH 114 514 242  HOH HOH A . 
G 4 HOH 115 515 41   HOH HOH A . 
G 4 HOH 116 516 446  HOH HOH A . 
G 4 HOH 117 517 128  HOH HOH A . 
G 4 HOH 118 518 62   HOH HOH A . 
G 4 HOH 119 519 540  HOH HOH A . 
G 4 HOH 120 520 245  HOH HOH A . 
G 4 HOH 121 521 97   HOH HOH A . 
G 4 HOH 122 522 460  HOH HOH A . 
G 4 HOH 123 523 657  HOH HOH A . 
G 4 HOH 124 524 681  HOH HOH A . 
G 4 HOH 125 525 158  HOH HOH A . 
G 4 HOH 126 526 12   HOH HOH A . 
G 4 HOH 127 527 358  HOH HOH A . 
G 4 HOH 128 528 827  HOH HOH A . 
G 4 HOH 129 529 180  HOH HOH A . 
G 4 HOH 130 530 119  HOH HOH A . 
G 4 HOH 131 531 134  HOH HOH A . 
G 4 HOH 132 532 1024 HOH HOH A . 
G 4 HOH 133 533 274  HOH HOH A . 
G 4 HOH 134 534 152  HOH HOH A . 
G 4 HOH 135 535 1001 HOH HOH A . 
G 4 HOH 136 536 51   HOH HOH A . 
G 4 HOH 137 537 605  HOH HOH A . 
G 4 HOH 138 538 331  HOH HOH A . 
G 4 HOH 139 539 629  HOH HOH A . 
G 4 HOH 140 540 101  HOH HOH A . 
G 4 HOH 141 541 111  HOH HOH A . 
G 4 HOH 142 542 205  HOH HOH A . 
G 4 HOH 143 543 133  HOH HOH A . 
G 4 HOH 144 544 107  HOH HOH A . 
G 4 HOH 145 545 39   HOH HOH A . 
G 4 HOH 146 546 164  HOH HOH A . 
G 4 HOH 147 547 422  HOH HOH A . 
G 4 HOH 148 548 131  HOH HOH A . 
G 4 HOH 149 549 65   HOH HOH A . 
G 4 HOH 150 550 572  HOH HOH A . 
G 4 HOH 151 551 507  HOH HOH A . 
G 4 HOH 152 552 631  HOH HOH A . 
G 4 HOH 153 553 123  HOH HOH A . 
G 4 HOH 154 554 57   HOH HOH A . 
G 4 HOH 155 555 374  HOH HOH A . 
G 4 HOH 156 556 557  HOH HOH A . 
G 4 HOH 157 557 674  HOH HOH A . 
G 4 HOH 158 558 194  HOH HOH A . 
G 4 HOH 159 559 249  HOH HOH A . 
G 4 HOH 160 560 90   HOH HOH A . 
G 4 HOH 161 561 442  HOH HOH A . 
G 4 HOH 162 562 559  HOH HOH A . 
G 4 HOH 163 563 467  HOH HOH A . 
G 4 HOH 164 564 418  HOH HOH A . 
G 4 HOH 165 565 126  HOH HOH A . 
G 4 HOH 166 566 480  HOH HOH A . 
G 4 HOH 167 567 542  HOH HOH A . 
G 4 HOH 168 568 793  HOH HOH A . 
G 4 HOH 169 569 445  HOH HOH A . 
G 4 HOH 170 570 227  HOH HOH A . 
G 4 HOH 171 571 281  HOH HOH A . 
G 4 HOH 172 572 963  HOH HOH A . 
G 4 HOH 173 573 335  HOH HOH A . 
G 4 HOH 174 574 933  HOH HOH A . 
G 4 HOH 175 575 995  HOH HOH A . 
G 4 HOH 176 576 403  HOH HOH A . 
G 4 HOH 177 577 169  HOH HOH A . 
G 4 HOH 178 578 770  HOH HOH A . 
G 4 HOH 179 579 283  HOH HOH A . 
G 4 HOH 180 580 309  HOH HOH A . 
G 4 HOH 181 581 224  HOH HOH A . 
G 4 HOH 182 582 555  HOH HOH A . 
G 4 HOH 183 583 266  HOH HOH A . 
G 4 HOH 184 584 488  HOH HOH A . 
G 4 HOH 185 585 768  HOH HOH A . 
G 4 HOH 186 586 466  HOH HOH A . 
G 4 HOH 187 587 523  HOH HOH A . 
G 4 HOH 188 588 355  HOH HOH A . 
G 4 HOH 189 589 1076 HOH HOH A . 
G 4 HOH 190 590 776  HOH HOH A . 
G 4 HOH 191 591 1027 HOH HOH A . 
G 4 HOH 192 592 607  HOH HOH A . 
G 4 HOH 193 593 161  HOH HOH A . 
G 4 HOH 194 594 253  HOH HOH A . 
G 4 HOH 195 595 379  HOH HOH A . 
G 4 HOH 196 596 448  HOH HOH A . 
G 4 HOH 197 597 1038 HOH HOH A . 
G 4 HOH 198 598 500  HOH HOH A . 
G 4 HOH 199 599 1083 HOH HOH A . 
G 4 HOH 200 600 369  HOH HOH A . 
G 4 HOH 201 601 244  HOH HOH A . 
G 4 HOH 202 602 435  HOH HOH A . 
G 4 HOH 203 603 360  HOH HOH A . 
G 4 HOH 204 604 340  HOH HOH A . 
G 4 HOH 205 605 361  HOH HOH A . 
G 4 HOH 206 606 208  HOH HOH A . 
G 4 HOH 207 607 512  HOH HOH A . 
G 4 HOH 208 608 414  HOH HOH A . 
G 4 HOH 209 609 725  HOH HOH A . 
G 4 HOH 210 610 50   HOH HOH A . 
G 4 HOH 211 611 868  HOH HOH A . 
G 4 HOH 212 612 1029 HOH HOH A . 
G 4 HOH 213 613 660  HOH HOH A . 
G 4 HOH 214 614 887  HOH HOH A . 
G 4 HOH 215 615 947  HOH HOH A . 
G 4 HOH 216 616 621  HOH HOH A . 
G 4 HOH 217 617 197  HOH HOH A . 
H 4 HOH 1   401 234  HOH HOH B . 
H 4 HOH 2   402 689  HOH HOH B . 
H 4 HOH 3   403 932  HOH HOH B . 
H 4 HOH 4   404 68   HOH HOH B . 
H 4 HOH 5   405 83   HOH HOH B . 
H 4 HOH 6   406 786  HOH HOH B . 
H 4 HOH 7   407 171  HOH HOH B . 
H 4 HOH 8   408 357  HOH HOH B . 
H 4 HOH 9   409 749  HOH HOH B . 
H 4 HOH 10  410 576  HOH HOH B . 
H 4 HOH 11  411 177  HOH HOH B . 
H 4 HOH 12  412 167  HOH HOH B . 
H 4 HOH 13  413 430  HOH HOH B . 
H 4 HOH 14  414 684  HOH HOH B . 
H 4 HOH 15  415 579  HOH HOH B . 
H 4 HOH 16  416 159  HOH HOH B . 
H 4 HOH 17  417 95   HOH HOH B . 
H 4 HOH 18  418 922  HOH HOH B . 
H 4 HOH 19  419 38   HOH HOH B . 
H 4 HOH 20  420 209  HOH HOH B . 
H 4 HOH 21  421 138  HOH HOH B . 
H 4 HOH 22  422 20   HOH HOH B . 
H 4 HOH 23  423 28   HOH HOH B . 
H 4 HOH 24  424 455  HOH HOH B . 
H 4 HOH 25  425 840  HOH HOH B . 
H 4 HOH 26  426 7    HOH HOH B . 
H 4 HOH 27  427 80   HOH HOH B . 
H 4 HOH 28  428 103  HOH HOH B . 
H 4 HOH 29  429 765  HOH HOH B . 
H 4 HOH 30  430 4    HOH HOH B . 
H 4 HOH 31  431 642  HOH HOH B . 
H 4 HOH 32  432 388  HOH HOH B . 
H 4 HOH 33  433 27   HOH HOH B . 
H 4 HOH 34  434 66   HOH HOH B . 
H 4 HOH 35  435 112  HOH HOH B . 
H 4 HOH 36  436 148  HOH HOH B . 
H 4 HOH 37  437 626  HOH HOH B . 
H 4 HOH 38  438 168  HOH HOH B . 
H 4 HOH 39  439 531  HOH HOH B . 
H 4 HOH 40  440 517  HOH HOH B . 
H 4 HOH 41  441 32   HOH HOH B . 
H 4 HOH 42  442 59   HOH HOH B . 
H 4 HOH 43  443 899  HOH HOH B . 
H 4 HOH 44  444 76   HOH HOH B . 
H 4 HOH 45  445 218  HOH HOH B . 
H 4 HOH 46  446 366  HOH HOH B . 
H 4 HOH 47  447 578  HOH HOH B . 
H 4 HOH 48  448 58   HOH HOH B . 
H 4 HOH 49  449 364  HOH HOH B . 
H 4 HOH 50  450 353  HOH HOH B . 
H 4 HOH 51  451 434  HOH HOH B . 
H 4 HOH 52  452 217  HOH HOH B . 
H 4 HOH 53  453 64   HOH HOH B . 
H 4 HOH 54  454 142  HOH HOH B . 
H 4 HOH 55  455 204  HOH HOH B . 
H 4 HOH 56  456 363  HOH HOH B . 
H 4 HOH 57  457 243  HOH HOH B . 
H 4 HOH 58  458 85   HOH HOH B . 
H 4 HOH 59  459 201  HOH HOH B . 
H 4 HOH 60  460 913  HOH HOH B . 
H 4 HOH 61  461 127  HOH HOH B . 
H 4 HOH 62  462 468  HOH HOH B . 
H 4 HOH 63  463 386  HOH HOH B . 
H 4 HOH 64  464 52   HOH HOH B . 
H 4 HOH 65  465 104  HOH HOH B . 
H 4 HOH 66  466 94   HOH HOH B . 
H 4 HOH 67  467 346  HOH HOH B . 
H 4 HOH 68  468 117  HOH HOH B . 
H 4 HOH 69  469 246  HOH HOH B . 
H 4 HOH 70  470 406  HOH HOH B . 
H 4 HOH 71  471 10   HOH HOH B . 
H 4 HOH 72  472 487  HOH HOH B . 
H 4 HOH 73  473 544  HOH HOH B . 
H 4 HOH 74  474 26   HOH HOH B . 
H 4 HOH 75  475 232  HOH HOH B . 
H 4 HOH 76  476 125  HOH HOH B . 
H 4 HOH 77  477 330  HOH HOH B . 
H 4 HOH 78  478 100  HOH HOH B . 
H 4 HOH 79  479 537  HOH HOH B . 
H 4 HOH 80  480 336  HOH HOH B . 
H 4 HOH 81  481 187  HOH HOH B . 
H 4 HOH 82  482 84   HOH HOH B . 
H 4 HOH 83  483 63   HOH HOH B . 
H 4 HOH 84  484 399  HOH HOH B . 
H 4 HOH 85  485 648  HOH HOH B . 
H 4 HOH 86  486 236  HOH HOH B . 
H 4 HOH 87  487 347  HOH HOH B . 
H 4 HOH 88  488 105  HOH HOH B . 
H 4 HOH 89  489 558  HOH HOH B . 
H 4 HOH 90  490 667  HOH HOH B . 
H 4 HOH 91  491 423  HOH HOH B . 
H 4 HOH 92  492 387  HOH HOH B . 
H 4 HOH 93  493 889  HOH HOH B . 
H 4 HOH 94  494 787  HOH HOH B . 
H 4 HOH 95  495 132  HOH HOH B . 
H 4 HOH 96  496 506  HOH HOH B . 
H 4 HOH 97  497 380  HOH HOH B . 
H 4 HOH 98  498 546  HOH HOH B . 
H 4 HOH 99  499 316  HOH HOH B . 
H 4 HOH 100 500 407  HOH HOH B . 
H 4 HOH 101 501 571  HOH HOH B . 
H 4 HOH 102 502 553  HOH HOH B . 
H 4 HOH 103 503 926  HOH HOH B . 
H 4 HOH 104 504 788  HOH HOH B . 
H 4 HOH 105 505 794  HOH HOH B . 
H 4 HOH 106 506 247  HOH HOH B . 
H 4 HOH 107 507 797  HOH HOH B . 
H 4 HOH 108 508 375  HOH HOH B . 
H 4 HOH 109 509 372  HOH HOH B . 
H 4 HOH 110 510 647  HOH HOH B . 
H 4 HOH 111 511 376  HOH HOH B . 
H 4 HOH 112 512 318  HOH HOH B . 
H 4 HOH 113 513 314  HOH HOH B . 
H 4 HOH 114 514 1014 HOH HOH B . 
H 4 HOH 115 515 1055 HOH HOH B . 
H 4 HOH 116 516 1017 HOH HOH B . 
H 4 HOH 117 517 44   HOH HOH B . 
H 4 HOH 118 518 301  HOH HOH B . 
H 4 HOH 119 519 248  HOH HOH B . 
H 4 HOH 120 520 901  HOH HOH B . 
H 4 HOH 121 521 1109 HOH HOH B . 
H 4 HOH 122 522 798  HOH HOH B . 
H 4 HOH 123 523 964  HOH HOH B . 
H 4 HOH 124 524 943  HOH HOH B . 
H 4 HOH 125 525 1061 HOH HOH B . 
H 4 HOH 126 526 651  HOH HOH B . 
H 4 HOH 127 527 586  HOH HOH B . 
H 4 HOH 128 528 1057 HOH HOH B . 
H 4 HOH 129 529 181  HOH HOH B . 
H 4 HOH 130 530 906  HOH HOH B . 
H 4 HOH 131 531 935  HOH HOH B . 
H 4 HOH 132 532 699  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ILE 24 ? CG1 ? A ILE 24 CG1 
2  1 Y 1 A ILE 24 ? CG2 ? A ILE 24 CG2 
3  1 Y 1 A ILE 24 ? CD1 ? A ILE 24 CD1 
4  1 Y 1 B ILE 24 ? CG1 ? B ILE 24 CG1 
5  1 Y 1 B ILE 24 ? CG2 ? B ILE 24 CG2 
6  1 Y 1 B ILE 24 ? CD1 ? B ILE 24 CD1 
7  1 Y 1 B ASP 93 ? CG  ? B ASP 93 CG  
8  1 Y 1 B ASP 93 ? OD1 ? B ASP 93 OD1 
9  1 Y 1 B ASP 93 ? OD2 ? B ASP 93 OD2 
10 1 Y 1 B ARG 94 ? CG  ? B ARG 94 CG  
11 1 Y 1 B ARG 94 ? CD  ? B ARG 94 CD  
12 1 Y 1 B ARG 94 ? NE  ? B ARG 94 NE  
13 1 Y 1 B ARG 94 ? CZ  ? B ARG 94 CZ  
14 1 Y 1 B ARG 94 ? NH1 ? B ARG 94 NH1 
15 1 Y 1 B ARG 94 ? NH2 ? B ARG 94 NH2 
16 1 Y 1 B ASP 95 ? CG  ? B ASP 95 CG  
17 1 Y 1 B ASP 95 ? OD1 ? B ASP 95 OD1 
18 1 Y 1 B ASP 95 ? OD2 ? B ASP 95 OD2 
19 1 Y 1 B VAL 96 ? CG1 ? B VAL 96 CG1 
20 1 Y 1 B VAL 96 ? CG2 ? B VAL 96 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .    4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   107.111 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQR 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     98.622 
_cell.length_a_esd                 ? 
_cell.length_b                     44.668 
_cell.length_b_esd                 ? 
_cell.length_c                     126.433 
_cell.length_c_esd                 ? 
_cell.volume                       532315.300 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQR 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQR 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.75 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.176 M KSCN, 20.8% (w/v) PEG 3350, 20 mM KCl' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-07-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97945 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97945 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          24.37 
_reflns.entry_id                                       9DQR 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     34947 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          29.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.03 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.7 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1715 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.883 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.57 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQR 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             40.36 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     34841 
_refine.ls_number_reflns_R_free                  1773 
_refine.ls_number_reflns_R_work                  33068 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.26 
_refine.ls_percent_reflns_R_free                 5.09 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1777 
_refine.ls_R_factor_R_free                       0.2107 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1759 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.1768 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1952 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        40.36 
_refine_hist.number_atoms_solvent             349 
_refine_hist.number_atoms_total               4099 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3730 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         20 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0132  ? 3878 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1683  ? 5255 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0804  ? 545  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0110  ? 714  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.7659 ? 1468 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.06  . . 140 2379 92.75 . . . . 0.2006 . . . . . . . . . . . 0.2404 
'X-RAY DIFFRACTION' 2.06 2.12  . . 115 2499 95.82 . . . . 0.2015 . . . . . . . . . . . 0.2934 
'X-RAY DIFFRACTION' 2.12 2.19  . . 137 2415 93.82 . . . . 0.1957 . . . . . . . . . . . 0.2634 
'X-RAY DIFFRACTION' 2.19 2.26  . . 142 2583 98.70 . . . . 0.1920 . . . . . . . . . . . 0.2166 
'X-RAY DIFFRACTION' 2.26 2.36  . . 111 2604 98.51 . . . . 0.1868 . . . . . . . . . . . 0.2209 
'X-RAY DIFFRACTION' 2.36 2.46  . . 134 2572 98.90 . . . . 0.1895 . . . . . . . . . . . 0.2244 
'X-RAY DIFFRACTION' 2.46 2.59  . . 151 2527 98.75 . . . . 0.1769 . . . . . . . . . . . 0.2023 
'X-RAY DIFFRACTION' 2.59 2.75  . . 137 2565 98.61 . . . . 0.1852 . . . . . . . . . . . 0.2081 
'X-RAY DIFFRACTION' 2.75 2.97  . . 149 2559 98.22 . . . . 0.1852 . . . . . . . . . . . 0.2200 
'X-RAY DIFFRACTION' 2.97 3.27  . . 139 2448 94.42 . . . . 0.1752 . . . . . . . . . . . 0.2172 
'X-RAY DIFFRACTION' 3.27 3.74  . . 144 2639 99.71 . . . . 0.1656 . . . . . . . . . . . 0.1662 
'X-RAY DIFFRACTION' 3.74 4.71  . . 122 2634 99.24 . . . . 0.1448 . . . . . . . . . . . 0.2013 
'X-RAY DIFFRACTION' 4.71 40.36 . . 152 2644 96.78 . . . . 0.1837 . . . . . . . . . . . 0.2096 
# 
_struct.entry_id                     9DQR 
_struct.title                        
'Crystal structure of HrmJ from Streptomyces sp. Ag109_G2-6 (HrmJ-ssa) complexed with vanadyl(IV)-oxo and succinate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQR 
_struct_keywords.text            'hydroxylase, non-heme iron 2OG enzyme, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A3N4ZHX0_9ACTN 
_struct_ref.pdbx_db_accession          A0A3N4ZHX0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQR A 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
2 1 9DQR B 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQR HIS A 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 1  
1 9DQR HIS A 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 2  
1 9DQR HIS A 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 3  
1 9DQR HIS A 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 4  
1 9DQR HIS A 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 5  
1 9DQR HIS A 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 6  
2 9DQR HIS B 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 7  
2 9DQR HIS B 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 8  
2 9DQR HIS B 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 9  
2 9DQR HIS B 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 10 
2 9DQR HIS B 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 11 
2 9DQR HIS B 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 2   ? GLY A 13  ? GLN A 2   GLY A 13  1 ? 12 
HELX_P HELX_P2  AA2 ASP A 25  ? GLU A 38  ? ASP A 25  GLU A 38  1 ? 14 
HELX_P HELX_P3  AA3 TRP A 39  ? LEU A 42  ? TRP A 39  LEU A 42  5 ? 4  
HELX_P HELX_P4  AA4 PRO A 78  ? ASN A 86  ? PRO A 78  ASN A 86  1 ? 9  
HELX_P HELX_P5  AA5 SER A 100 ? ASN A 106 ? SER A 100 ASN A 106 1 ? 7  
HELX_P HELX_P6  AA6 ASN A 106 ? GLU A 118 ? ASN A 106 GLU A 118 1 ? 13 
HELX_P HELX_P7  AA7 GLU A 124 ? ASP A 130 ? GLU A 124 ASP A 130 5 ? 7  
HELX_P HELX_P8  AA8 GLU B 4   ? GLY B 13  ? GLU B 4   GLY B 13  1 ? 10 
HELX_P HELX_P9  AA9 PRO B 18  ? LEU B 22  ? PRO B 18  LEU B 22  5 ? 5  
HELX_P HELX_P10 AB1 ASP B 25  ? GLU B 38  ? ASP B 25  GLU B 38  1 ? 14 
HELX_P HELX_P11 AB2 TRP B 39  ? ASN B 41  ? TRP B 39  ASN B 41  5 ? 3  
HELX_P HELX_P12 AB3 ARG B 77  ? GLN B 81  ? ARG B 77  GLN B 81  5 ? 5  
HELX_P HELX_P13 AB4 SER B 100 ? ASN B 106 ? SER B 100 ASN B 106 1 ? 7  
HELX_P HELX_P14 AB5 PRO B 107 ? GLU B 118 ? PRO B 107 GLU B 118 1 ? 12 
HELX_P HELX_P15 AB6 GLU B 124 ? ASP B 130 ? GLU B 124 ASP B 130 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 157 NE2 ? ? ? 1_555 D VVO . V1 ? ? A HIS 157 A VVO 302 1_555 ? ? ? ? ? ? ? 2.387 ? ? 
metalc2  metalc ? ? A ASP 159 OD1 ? ? ? 1_555 D VVO . V1 ? ? A ASP 159 A VVO 302 1_555 ? ? ? ? ? ? ? 2.240 ? ? 
metalc3  metalc ? ? A HIS 210 NE2 ? ? ? 1_555 D VVO . V1 ? ? A HIS 210 A VVO 302 1_555 ? ? ? ? ? ? ? 2.346 ? ? 
metalc4  metalc ? ? C SIN .   O2  ? ? ? 1_555 D VVO . V1 ? ? A SIN 301 A VVO 302 1_555 ? ? ? ? ? ? ? 2.107 ? ? 
metalc5  metalc ? ? D VVO .   V1  ? ? ? 1_555 G HOH . O  ? ? A VVO 302 A HOH 414 1_555 ? ? ? ? ? ? ? 2.401 ? ? 
metalc6  metalc ? ? B ASN 84  OD1 ? ? ? 1_555 F VVO . V1 ? ? B ASN 84  B VVO 302 1_555 ? ? ? ? ? ? ? 2.426 ? ? 
metalc7  metalc ? ? B ASN 86  ND2 ? ? ? 1_555 F VVO . V1 ? ? B ASN 86  B VVO 302 1_555 ? ? ? ? ? ? ? 2.104 ? ? 
metalc8  metalc ? ? B HIS 157 NE2 ? ? ? 1_555 F VVO . V1 ? ? B HIS 157 B VVO 302 1_555 ? ? ? ? ? ? ? 2.484 ? ? 
metalc9  metalc ? ? B ASP 159 OD1 ? ? ? 1_555 F VVO . V1 ? ? B ASP 159 B VVO 302 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc10 metalc ? ? B HIS 210 NE2 ? ? ? 1_555 F VVO . V1 ? ? B HIS 210 B VVO 302 1_555 ? ? ? ? ? ? ? 2.358 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? D VVO .   ? A VVO 302 ? 1_555 98.8  ? 
2  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 OD1 ? A ASP 159 ? A ASP 159 ? 1_555 106.5 ? 
3  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 OD1 ? A ASP 159 ? A ASP 159 ? 1_555 86.2  ? 
4  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 87.1  ? 
5  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 171.5 ? 
6  OD1 ? A ASP 159 ? A ASP 159 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 86.3  ? 
7  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O2  ? C SIN .   ? A SIN 301 ? 1_555 83.4  ? 
8  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O2  ? C SIN .   ? A SIN 301 ? 1_555 94.1  ? 
9  OD1 ? A ASP 159 ? A ASP 159 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O2  ? C SIN .   ? A SIN 301 ? 1_555 169.9 ? 
10 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O2  ? C SIN .   ? A SIN 301 ? 1_555 92.7  ? 
11 NE2 ? A HIS 157 ? A HIS 157 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? G HOH .   ? A HOH 414 ? 1_555 168.4 ? 
12 O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? G HOH .   ? A HOH 414 ? 1_555 79.9  ? 
13 OD1 ? A ASP 159 ? A ASP 159 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? G HOH .   ? A HOH 414 ? 1_555 84.9  ? 
14 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? G HOH .   ? A HOH 414 ? 1_555 95.7  ? 
15 O2  ? C SIN .   ? A SIN 301 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? G HOH .   ? A HOH 414 ? 1_555 85.2  ? 
16 OD1 ? B ASN 84  ? B ASN 84  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 O1  ? F VVO .   ? B VVO 302 ? 1_555 88.4  ? 
17 OD1 ? B ASN 84  ? B ASN 84  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 ND2 ? B ASN 86  ? B ASN 86  ? 1_555 91.6  ? 
18 O1  ? F VVO .   ? B VVO 302 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 ND2 ? B ASN 86  ? B ASN 86  ? 1_555 82.0  ? 
19 OD1 ? B ASN 84  ? B ASN 84  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 157 ? B HIS 157 ? 1_555 87.9  ? 
20 O1  ? F VVO .   ? B VVO 302 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 157 ? B HIS 157 ? 1_555 167.6 ? 
21 ND2 ? B ASN 86  ? B ASN 86  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 157 ? B HIS 157 ? 1_555 86.3  ? 
22 OD1 ? B ASN 84  ? B ASN 84  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 88.1  ? 
23 O1  ? F VVO .   ? B VVO 302 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 94.3  ? 
24 ND2 ? B ASN 86  ? B ASN 86  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 176.3 ? 
25 NE2 ? B HIS 157 ? B HIS 157 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 97.4  ? 
26 OD1 ? B ASN 84  ? B ASN 84  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 179.3 ? 
27 O1  ? F VVO .   ? B VVO 302 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 91.8  ? 
28 ND2 ? B ASN 86  ? B ASN 86  ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 89.1  ? 
29 NE2 ? B HIS 157 ? B HIS 157 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 92.1  ? 
30 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 V1 ? F VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 91.2  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 3 ? 
AA5 ? 7 ? 
AA6 ? 7 ? 
AA7 ? 2 ? 
AA8 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA6 6 7 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 14  ? LEU A 17  ? TYR A 14  LEU A 17  
AA1 2 THR A 200 ? SER A 204 ? THR A 200 SER A 204 
AA1 3 PHE A 163 ? PHE A 172 ? PHE A 163 PHE A 172 
AA1 4 ALA A 224 ? HIS A 235 ? ALA A 224 HIS A 235 
AA1 5 TRP A 132 ? SER A 143 ? TRP A 132 SER A 143 
AA1 6 PHE A 54  ? VAL A 65  ? PHE A 54  VAL A 65  
AA1 7 GLU A 70  ? LEU A 73  ? GLU A 70  LEU A 73  
AA2 1 GLU A 43  ? THR A 44  ? GLU A 43  THR A 44  
AA2 2 PHE A 54  ? VAL A 65  ? PHE A 54  VAL A 65  
AA2 3 ALA A 97  ? PRO A 98  ? ALA A 97  PRO A 98  
AA3 1 ALA A 174 ? GLY A 176 ? ALA A 174 GLY A 176 
AA3 2 ILE A 215 ? PRO A 217 ? ILE A 215 PRO A 217 
AA4 1 LEU A 188 ? PHE A 192 ? LEU A 188 PHE A 192 
AA4 2 SER A 179 ? TYR A 182 ? SER A 179 TYR A 182 
AA4 3 LEU A 209 ? VAL A 212 ? LEU A 209 VAL A 212 
AA5 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA5 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA5 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA5 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA5 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA5 6 ARG B 53  ? VAL B 65  ? ARG B 53  VAL B 65  
AA5 7 GLU B 43  ? THR B 44  ? GLU B 43  THR B 44  
AA6 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA6 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA6 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA6 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA6 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA6 6 ARG B 53  ? VAL B 65  ? ARG B 53  VAL B 65  
AA6 7 GLU B 70  ? LEU B 73  ? GLU B 70  LEU B 73  
AA7 1 ALA B 174 ? GLY B 176 ? ALA B 174 GLY B 176 
AA7 2 ILE B 215 ? PRO B 217 ? ILE B 215 PRO B 217 
AA8 1 LEU B 188 ? PHE B 192 ? LEU B 188 PHE B 192 
AA8 2 SER B 179 ? TYR B 182 ? SER B 179 TYR B 182 
AA8 3 LEU B 209 ? VAL B 212 ? LEU B 209 VAL B 212 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 17  ? N LEU A 17  O THR A 200 ? O THR A 200 
AA1 2 3 O TRP A 203 ? O TRP A 203 N GLY A 164 ? N GLY A 164 
AA1 3 4 N PHE A 163 ? N PHE A 163 O TYR A 233 ? O TYR A 233 
AA1 4 5 O ILE A 230 ? O ILE A 230 N HIS A 137 ? N HIS A 137 
AA1 5 6 O CYS A 136 ? O CYS A 136 N ASP A 60  ? N ASP A 60  
AA1 6 7 N PHE A 63  ? N PHE A 63  O ARG A 72  ? O ARG A 72  
AA2 1 2 N GLU A 43  ? N GLU A 43  O ARG A 57  ? O ARG A 57  
AA2 2 3 N TYR A 59  ? N TYR A 59  O ALA A 97  ? O ALA A 97  
AA3 1 2 N ALA A 175 ? N ALA A 175 O HIS A 216 ? O HIS A 216 
AA4 1 2 O ALA A 190 ? O ALA A 190 N VAL A 181 ? N VAL A 181 
AA4 2 3 N GLN A 180 ? N GLN A 180 O ALA A 211 ? O ALA A 211 
AA5 1 2 N LEU B 17  ? N LEU B 17  O THR B 200 ? O THR B 200 
AA5 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA5 3 4 N GLY B 170 ? N GLY B 170 O ASP B 227 ? O ASP B 227 
AA5 4 5 O ALA B 224 ? O ALA B 224 N SER B 143 ? N SER B 143 
AA5 5 6 O ARG B 140 ? O ARG B 140 N GLU B 56  ? N GLU B 56  
AA5 6 7 O ARG B 57  ? O ARG B 57  N GLU B 43  ? N GLU B 43  
AA6 1 2 N LEU B 17  ? N LEU B 17  O THR B 200 ? O THR B 200 
AA6 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA6 3 4 N GLY B 170 ? N GLY B 170 O ASP B 227 ? O ASP B 227 
AA6 4 5 O ALA B 224 ? O ALA B 224 N SER B 143 ? N SER B 143 
AA6 5 6 O ARG B 140 ? O ARG B 140 N GLU B 56  ? N GLU B 56  
AA6 6 7 N PHE B 63  ? N PHE B 63  O ARG B 72  ? O ARG B 72  
AA7 1 2 N ALA B 175 ? N ALA B 175 O HIS B 216 ? O HIS B 216 
AA8 1 2 O PHE B 192 ? O PHE B 192 N SER B 179 ? N SER B 179 
AA8 2 3 N GLN B 180 ? N GLN B 180 O ALA B 211 ? O ALA B 211 
# 
_pdbx_entry_details.entry_id                   9DQR 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   B HOH 528 ? ? O   B HOH 531 ? ? 1.59 
2  1 O   A HOH 527 ? ? O   A HOH 543 ? ? 1.68 
3  1 O   A HOH 513 ? ? O   A HOH 523 ? ? 1.72 
4  1 O   A HOH 458 ? ? O   A HOH 586 ? ? 1.72 
5  1 O   B HOH 512 ? ? O   B HOH 522 ? ? 1.76 
6  1 O   A HOH 606 ? ? O   A HOH 607 ? ? 1.84 
7  1 O   A HOH 494 ? ? O   A HOH 520 ? ? 1.88 
8  1 O   A HOH 605 ? ? O   B HOH 529 ? ? 1.91 
9  1 O   A HOH 500 ? ? O   A HOH 573 ? ? 2.00 
10 1 O   A HOH 482 ? ? O   A HOH 576 ? ? 2.00 
11 1 OE2 B GLU 118 ? ? O   B HOH 401 ? ? 2.01 
12 1 O   B HOH 486 ? ? O   B HOH 519 ? ? 2.02 
13 1 O   A HOH 460 ? ? O   A HOH 567 ? ? 2.02 
14 1 O   A LEU 184 ? ? O   A HOH 401 ? ? 2.04 
15 1 NH2 B ARG 10  ? ? O   B HOH 402 ? ? 2.06 
16 1 OH  B TYR 182 ? ? O   B HOH 403 ? ? 2.06 
17 1 O   A HOH 412 ? ? O   A HOH 592 ? ? 2.07 
18 1 O   A HOH 612 ? ? O   A HOH 615 ? ? 2.07 
19 1 O   A HOH 511 ? ? O   A HOH 611 ? ? 2.08 
20 1 O   A HOH 539 ? ? O   A HOH 590 ? ? 2.08 
21 1 O   B HOH 429 ? ? O   B HOH 444 ? ? 2.09 
22 1 NE  B ARG 213 ? ? O   B HOH 404 ? ? 2.10 
23 1 OG  B SER 52  ? ? O   B HOH 405 ? ? 2.10 
24 1 NH1 A ARG 111 ? ? O   A HOH 402 ? ? 2.10 
25 1 NH1 B ARG 67  ? A O   B HOH 406 ? ? 2.11 
26 1 O   A HOH 431 ? ? O   A HOH 527 ? ? 2.11 
27 1 N   A GLN 2   ? ? O   A HOH 403 ? ? 2.13 
28 1 OG1 B THR 3   ? ? NH1 B ARG 6   ? ? 2.15 
29 1 OE2 B GLU 27  ? ? O   B HOH 407 ? ? 2.16 
30 1 O   A HOH 459 ? ? O   A HOH 520 ? ? 2.17 
31 1 OE1 A GLU 118 ? A O   A HOH 404 ? ? 2.18 
32 1 O   A HOH 418 ? ? O   A HOH 587 ? ? 2.18 
33 1 OE2 B GLU 160 ? ? O   B HOH 408 ? ? 2.19 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 425 ? ? 1_555 O A HOH 507 ? ? 4_546 1.83 
2 1 O A HOH 568 ? ? 1_555 O A HOH 600 ? ? 4_556 1.89 
3 1 O A HOH 500 ? ? 1_555 O A HOH 531 ? ? 4_556 1.92 
4 1 O A HOH 550 ? ? 1_555 O A HOH 579 ? ? 4_556 1.96 
5 1 O B HOH 489 ? ? 1_555 O B HOH 505 ? ? 1_565 2.04 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 22  ? ? 53.73   102.48  
2  1 ILE A 24  ? ? 178.60  141.64  
3  1 THR A 44  ? ? -58.24  97.44   
4  1 ASP A 87  ? ? -161.01 103.04  
5  1 ASP B 45  ? ? 117.37  -146.51 
6  1 SER B 52  ? ? 92.11   -43.14  
7  1 ARG B 94  ? ? -160.41 -136.27 
8  1 ALA B 97  ? ? -155.48 64.32   
9  1 PRO B 145 ? ? -39.66  119.95  
10 1 GLU B 160 ? ? 71.07   42.10   
11 1 ARG B 186 ? ? 72.76   31.48   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ARG 46  ? A ARG 46  
3  1 Y 1 A TYR 47  ? A TYR 47  
4  1 Y 1 A LEU 48  ? A LEU 48  
5  1 Y 1 A LYS 49  ? A LYS 49  
6  1 Y 1 A GLY 50  ? A GLY 50  
7  1 Y 1 A GLY 51  ? A GLY 51  
8  1 Y 1 A SER 52  ? A SER 52  
9  1 Y 1 A GLU 147 ? A GLU 147 
10 1 Y 1 A THR 148 ? A THR 148 
11 1 Y 1 A GLY 149 ? A GLY 149 
12 1 Y 1 A GLU 150 ? A GLU 150 
13 1 Y 1 A PRO 151 ? A PRO 151 
14 1 Y 1 A THR 152 ? A THR 152 
15 1 Y 1 A GLY 245 ? A GLY 245 
16 1 Y 1 A ALA 246 ? A ALA 246 
17 1 Y 1 A ALA 247 ? A ALA 247 
18 1 Y 1 A HIS 248 ? A HIS 248 
19 1 Y 1 A HIS 249 ? A HIS 249 
20 1 Y 1 A HIS 250 ? A HIS 250 
21 1 Y 1 A HIS 251 ? A HIS 251 
22 1 Y 1 A HIS 252 ? A HIS 252 
23 1 Y 1 A HIS 253 ? A HIS 253 
24 1 Y 1 B MET 1   ? B MET 1   
25 1 Y 1 B GLN 2   ? B GLN 2   
26 1 Y 1 B TYR 47  ? B TYR 47  
27 1 Y 1 B LEU 48  ? B LEU 48  
28 1 Y 1 B LYS 49  ? B LYS 49  
29 1 Y 1 B GLY 50  ? B GLY 50  
30 1 Y 1 B TYR 88  ? B TYR 88  
31 1 Y 1 B ALA 89  ? B ALA 89  
32 1 Y 1 B GLY 90  ? B GLY 90  
33 1 Y 1 B GLY 91  ? B GLY 91  
34 1 Y 1 B ILE 92  ? B ILE 92  
35 1 Y 1 B THR 148 ? B THR 148 
36 1 Y 1 B GLY 149 ? B GLY 149 
37 1 Y 1 B GLU 150 ? B GLU 150 
38 1 Y 1 B PRO 151 ? B PRO 151 
39 1 Y 1 B THR 152 ? B THR 152 
40 1 Y 1 B PRO 153 ? B PRO 153 
41 1 Y 1 B GLN 244 ? B GLN 244 
42 1 Y 1 B GLY 245 ? B GLY 245 
43 1 Y 1 B ALA 246 ? B ALA 246 
44 1 Y 1 B ALA 247 ? B ALA 247 
45 1 Y 1 B HIS 248 ? B HIS 248 
46 1 Y 1 B HIS 249 ? B HIS 249 
47 1 Y 1 B HIS 250 ? B HIS 250 
48 1 Y 1 B HIS 251 ? B HIS 251 
49 1 Y 1 B HIS 252 ? B HIS 252 
50 1 Y 1 B HIS 253 ? B HIS 253 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
SIN C1   C N N 304 
SIN O1   O N N 305 
SIN O2   O N N 306 
SIN C2   C N N 307 
SIN C3   C N N 308 
SIN C4   C N N 309 
SIN O3   O N N 310 
SIN O4   O N N 311 
SIN HO2  H N N 312 
SIN H21  H N N 313 
SIN H22  H N N 314 
SIN H31  H N N 315 
SIN H32  H N N 316 
SIN HO4  H N N 317 
THR N    N N N 318 
THR CA   C N S 319 
THR C    C N N 320 
THR O    O N N 321 
THR CB   C N R 322 
THR OG1  O N N 323 
THR CG2  C N N 324 
THR OXT  O N N 325 
THR H    H N N 326 
THR H2   H N N 327 
THR HA   H N N 328 
THR HB   H N N 329 
THR HG1  H N N 330 
THR HG21 H N N 331 
THR HG22 H N N 332 
THR HG23 H N N 333 
THR HXT  H N N 334 
TRP N    N N N 335 
TRP CA   C N S 336 
TRP C    C N N 337 
TRP O    O N N 338 
TRP CB   C N N 339 
TRP CG   C Y N 340 
TRP CD1  C Y N 341 
TRP CD2  C Y N 342 
TRP NE1  N Y N 343 
TRP CE2  C Y N 344 
TRP CE3  C Y N 345 
TRP CZ2  C Y N 346 
TRP CZ3  C Y N 347 
TRP CH2  C Y N 348 
TRP OXT  O N N 349 
TRP H    H N N 350 
TRP H2   H N N 351 
TRP HA   H N N 352 
TRP HB2  H N N 353 
TRP HB3  H N N 354 
TRP HD1  H N N 355 
TRP HE1  H N N 356 
TRP HE3  H N N 357 
TRP HZ2  H N N 358 
TRP HZ3  H N N 359 
TRP HH2  H N N 360 
TRP HXT  H N N 361 
TYR N    N N N 362 
TYR CA   C N S 363 
TYR C    C N N 364 
TYR O    O N N 365 
TYR CB   C N N 366 
TYR CG   C Y N 367 
TYR CD1  C Y N 368 
TYR CD2  C Y N 369 
TYR CE1  C Y N 370 
TYR CE2  C Y N 371 
TYR CZ   C Y N 372 
TYR OH   O N N 373 
TYR OXT  O N N 374 
TYR H    H N N 375 
TYR H2   H N N 376 
TYR HA   H N N 377 
TYR HB2  H N N 378 
TYR HB3  H N N 379 
TYR HD1  H N N 380 
TYR HD2  H N N 381 
TYR HE1  H N N 382 
TYR HE2  H N N 383 
TYR HH   H N N 384 
TYR HXT  H N N 385 
VAL N    N N N 386 
VAL CA   C N S 387 
VAL C    C N N 388 
VAL O    O N N 389 
VAL CB   C N N 390 
VAL CG1  C N N 391 
VAL CG2  C N N 392 
VAL OXT  O N N 393 
VAL H    H N N 394 
VAL H2   H N N 395 
VAL HA   H N N 396 
VAL HB   H N N 397 
VAL HG11 H N N 398 
VAL HG12 H N N 399 
VAL HG13 H N N 400 
VAL HG21 H N N 401 
VAL HG22 H N N 402 
VAL HG23 H N N 403 
VAL HXT  H N N 404 
VVO O1   O N N 405 
VVO V1   V N N 406 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
SIN C1  O1   doub N N 290 
SIN C1  O2   sing N N 291 
SIN C1  C2   sing N N 292 
SIN O2  HO2  sing N N 293 
SIN C2  C3   sing N N 294 
SIN C2  H21  sing N N 295 
SIN C2  H22  sing N N 296 
SIN C3  C4   sing N N 297 
SIN C3  H31  sing N N 298 
SIN C3  H32  sing N N 299 
SIN C4  O3   doub N N 300 
SIN C4  O4   sing N N 301 
SIN O4  HO4  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
VVO V1  O1   doub N N 389 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9DQP 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.crystal_system   monoclinic 
_space_group.IT_number        5 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DQR 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010140 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003122 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.022387 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008276 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
V ? ? 18.66134 4.26681 ? ? 3.12589  55.31642 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 2   ? 13.19833  18.20972  40.42282  1.000 41.57488  ? 2   GLN A N   1 
ATOM   2    C CA  . GLN A 1 2   ? 11.93313  17.48580  40.60658  1.000 37.91416  ? 2   GLN A CA  1 
ATOM   3    C C   . GLN A 1 2   ? 10.96349  17.81417  39.45134  1.000 41.13196  ? 2   GLN A C   1 
ATOM   4    O O   . GLN A 1 2   ? 10.27338  16.91867  38.94201  1.000 31.58591  ? 2   GLN A O   1 
ATOM   5    C CB  . GLN A 1 2   ? 11.31312  17.81115  41.96444  1.000 39.66543  ? 2   GLN A CB  1 
ATOM   6    C CG  . GLN A 1 2   ? 10.88092  19.27692  42.05902  1.000 75.93601  ? 2   GLN A CG  1 
ATOM   7    C CD  . GLN A 1 2   ? 10.70180  19.77974  43.47603  1.000 85.57601  ? 2   GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 2   ? 10.05626  19.12933  44.30560  1.000 72.56601  ? 2   GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 2   ? 11.26925  20.95845  43.76167  1.000 93.31440  ? 2   GLN A NE2 1 
ATOM   10   N N   . THR A 1 3   ? 10.92662  19.07939  39.00500  1.000 41.21491  ? 3   THR A N   1 
ATOM   11   C CA  . THR A 1 3   ? 10.03418  19.44452  37.89868  1.000 38.11784  ? 3   THR A CA  1 
ATOM   12   C C   . THR A 1 3   ? 10.44263  18.74153  36.60716  1.000 24.79629  ? 3   THR A C   1 
ATOM   13   O O   . THR A 1 3   ? 9.59990   18.18472  35.89683  1.000 28.82618  ? 3   THR A O   1 
ATOM   14   C CB  . THR A 1 3   ? 10.01406  20.97088  37.68689  1.000 46.05173  ? 3   THR A CB  1 
ATOM   15   O OG1 . THR A 1 3   ? 9.46743   21.62512  38.83553  1.000 46.66656  ? 3   THR A OG1 1 
ATOM   16   C CG2 . THR A 1 3   ? 9.15392   21.32745  36.48890  1.000 42.80187  ? 3   THR A CG2 1 
ATOM   17   N N   . GLU A 1 4   ? 11.73273  18.78541  36.27798  1.000 33.71419  ? 4   GLU A N   1 
ATOM   18   C CA  . GLU A 1 4   ? 12.22813  18.07470  35.10980  1.000 37.12123  ? 4   GLU A CA  1 
ATOM   19   C C   . GLU A 1 4   ? 12.03667  16.56990  35.24472  1.000 29.78741  ? 4   GLU A C   1 
ATOM   20   O O   . GLU A 1 4   ? 11.71031  15.89544  34.26051  1.000 27.05226  ? 4   GLU A O   1 
ATOM   21   C CB  . GLU A 1 4   ? 13.70159  18.39923  34.88080  1.000 47.97866  ? 4   GLU A CB  1 
ATOM   22   C CG  . GLU A 1 4   ? 14.21103  17.86965  33.53685  1.000 55.74964  ? 4   GLU A CG  1 
ATOM   23   C CD  . GLU A 1 4   ? 15.66462  18.24727  33.25049  1.000 87.63920  ? 4   GLU A CD  1 
ATOM   24   O OE1 . GLU A 1 4   ? 16.44209  18.39175  34.22383  1.000 91.29168  ? 4   GLU A OE1 1 
ATOM   25   O OE2 . GLU A 1 4   ? 16.02633  18.39819  32.05318  1.000 82.20115  ? 4   GLU A OE2 1 
ATOM   26   N N   . ALA A 1 5   ? 12.23566  16.01712  36.45243  1.000 26.46009  ? 5   ALA A N   1 
ATOM   27   C CA  . ALA A 1 5   ? 12.04403  14.57404  36.61288  1.000 22.78373  ? 5   ALA A CA  1 
ATOM   28   C C   . ALA A 1 5   ? 10.59407  14.19859  36.38604  1.000 24.48550  ? 5   ALA A C   1 
ATOM   29   O O   . ALA A 1 5   ? 10.29862  13.19077  35.72718  1.000 19.78723  ? 5   ALA A O   1 
ATOM   30   C CB  . ALA A 1 5   ? 12.50243  14.11686  38.00260  1.000 23.08061  ? 5   ALA A CB  1 
ATOM   31   N N   . ARG A 1 6   ? 9.66195   14.99078  36.94009  1.000 22.57293  ? 6   ARG A N   1 
ATOM   32   C CA  . ARG A 1 6   ? 8.25096   14.66566  36.74161  1.000 24.72072  ? 6   ARG A CA  1 
ATOM   33   C C   . ARG A 1 6   ? 7.89560   14.69412  35.26784  1.000 21.56065  ? 6   ARG A C   1 
ATOM   34   O O   . ARG A 1 6   ? 7.12506   13.85671  34.78331  1.000 23.66083  ? 6   ARG A O   1 
ATOM   35   C CB  . ARG A 1 6   ? 7.36329   15.66720  37.48996  1.000 29.51711  ? 6   ARG A CB  1 
ATOM   36   C CG  . ARG A 1 6   ? 7.31112   15.54518  38.99043  1.000 28.25197  ? 6   ARG A CG  1 
ATOM   37   C CD  . ARG A 1 6   ? 6.54535   16.78082  39.40736  1.000 29.47091  ? 6   ARG A CD  1 
ATOM   38   N NE  . ARG A 1 6   ? 5.89544   16.62900  40.68220  1.000 40.61114  ? 6   ARG A NE  1 
ATOM   39   C CZ  . ARG A 1 6   ? 6.21670   17.34672  41.74842  1.000 54.73601  ? 6   ARG A CZ  1 
ATOM   40   N NH1 . ARG A 1 6   ? 7.17938   18.25273  41.70341  1.000 50.79299  ? 6   ARG A NH1 1 
ATOM   41   N NH2 . ARG A 1 6   ? 5.56602   17.14358  42.89012  1.000 41.58634  ? 6   ARG A NH2 1 
ATOM   42   N N   . GLU A 1 7   ? 8.43787   15.66223  34.53552  1.000 24.39504  ? 7   GLU A N   1 
ATOM   43   C CA  . GLU A 1 7   ? 8.12336   15.73021  33.10701  1.000 26.03444  ? 7   GLU A CA  1 
ATOM   44   C C   . GLU A 1 7   ? 8.78028   14.58440  32.34761  1.000 26.88860  ? 7   GLU A C   1 
ATOM   45   O O   . GLU A 1 7   ? 8.20140   14.04431  31.40562  1.000 26.54214  ? 7   GLU A O   1 
ATOM   46   C CB  . GLU A 1 7   ? 8.55417   17.07901  32.53000  1.000 34.37098  ? 7   GLU A CB  1 
ATOM   47   C CG  . GLU A 1 7   ? 8.17212   17.25531  31.05413  1.000 41.54411  ? 7   GLU A CG  1 
ATOM   48   C CD  . GLU A 1 7   ? 6.68699   16.96901  30.81381  1.000 55.81601  ? 7   GLU A CD  1 
ATOM   49   O OE1 . GLU A 1 7   ? 5.83728   17.49753  31.58977  1.000 45.10533  ? 7   GLU A OE1 1 
ATOM   50   O OE2 . GLU A 1 7   ? 6.37941   16.19420  29.86752  1.000 48.73391  ? 7   GLU A OE2 1 
ATOM   51   N N   . GLU A 1 8   ? 9.96828   14.17983  32.76264  1.000 22.86566  ? 8   GLU A N   1 
ATOM   52   C CA  . GLU A 1 8   ? 10.61114  13.04373  32.11295  1.000 23.15591  ? 8   GLU A CA  1 
ATOM   53   C C   . GLU A 1 8   ? 9.85220   11.75425  32.37609  1.000 20.83203  ? 8   GLU A C   1 
ATOM   54   O O   . GLU A 1 8   ? 9.78110   10.88883  31.49305  1.000 19.82822  ? 8   GLU A O   1 
ATOM   55   C CB  . GLU A 1 8   ? 12.06599  12.94991  32.57398  1.000 21.75747  ? 8   GLU A CB  1 
ATOM   56   C CG  . GLU A 1 8   ? 12.99607  14.03531  31.92494  1.000 25.53464  ? 8   GLU A CG  1 
ATOM   57   C CD  . GLU A 1 8   ? 14.44226  13.94295  32.40327  1.000 29.83884  ? 8   GLU A CD  1 
ATOM   58   O OE1 . GLU A 1 8   ? 14.72706  13.15464  33.34573  1.000 26.45863  ? 8   GLU A OE1 1 
ATOM   59   O OE2 . GLU A 1 8   ? 15.31127  14.64124  31.85697  1.000 33.32336  ? 8   GLU A OE2 1 
ATOM   60   N N   . LEU A 1 9   ? 9.27120   11.59722  33.58036  1.000 19.51934  ? 9   LEU A N   1 
ATOM   61   C CA  . LEU A 1 9   ? 8.39631   10.44287  33.79858  1.000 17.17091  ? 9   LEU A CA  1 
ATOM   62   C C   . LEU A 1 9   ? 7.17534   10.53060  32.89380  1.000 18.77936  ? 9   LEU A C   1 
ATOM   63   O O   . LEU A 1 9   ? 6.76233   9.52786   32.29352  1.000 18.17140  ? 9   LEU A O   1 
ATOM   64   C CB  . LEU A 1 9   ? 7.96935   10.30611  35.29583  1.000 16.71140  ? 9   LEU A CB  1 
ATOM   65   C CG  . LEU A 1 9   ? 8.80603   9.23317   36.08620  1.000 18.01434  ? 9   LEU A CG  1 
ATOM   66   C CD1 . LEU A 1 9   ? 10.26092  9.64392   36.10690  1.000 16.76687  ? 9   LEU A CD1 1 
ATOM   67   C CD2 . LEU A 1 9   ? 8.33769   9.01793   37.56130  1.000 17.37515  ? 9   LEU A CD2 1 
ATOM   68   N N   . ARG A 1 10  ? 6.57234   11.71385  32.78495  1.000 19.39408  ? 10  ARG A N   1 
ATOM   69   C CA  . ARG A 1 10  ? 5.38397   11.82077  31.93277  1.000 29.70176  ? 10  ARG A CA  1 
ATOM   70   C C   . ARG A 1 10  ? 5.71720   11.46913  30.48489  1.000 20.90111  ? 10  ARG A C   1 
ATOM   71   O O   . ARG A 1 10  ? 5.03933   10.64885  29.86218  1.000 23.15723  ? 10  ARG A O   1 
ATOM   72   C CB  . ARG A 1 10  ? 4.80243   13.23386  31.98163  1.000 27.17051  ? 10  ARG A CB  1 
ATOM   73   C CG  . ARG A 1 10  ? 3.98397   13.52229  33.18974  1.000 29.77573  ? 10  ARG A CG  1 
ATOM   74   C CD  . ARG A 1 10  ? 3.22796   14.87906  33.03279  1.000 32.24311  ? 10  ARG A CD  1 
ATOM   75   N NE  . ARG A 1 10  ? 2.99449   15.41794  34.36418  1.000 37.80066  ? 10  ARG A NE  1 
ATOM   76   C CZ  . ARG A 1 10  ? 3.81132   16.26388  34.98245  1.000 34.88153  ? 10  ARG A CZ  1 
ATOM   77   N NH1 . ARG A 1 10  ? 4.83975   16.81535  34.35712  1.000 33.42652  ? 10  ARG A NH1 1 
ATOM   78   N NH2 . ARG A 1 10  ? 3.59379   16.55755  36.26621  1.000 40.49266  ? 10  ARG A NH2 1 
ATOM   79   N N   . ALA A 1 11  ? 6.78822   12.05216  29.95106  1.000 22.07595  ? 11  ALA A N   1 
ATOM   80   C CA  . ALA A 1 11  ? 7.11828   11.83945  28.53912  1.000 23.40891  ? 11  ALA A CA  1 
ATOM   81   C C   . ALA A 1 11  ? 7.74376   10.47520  28.26624  1.000 22.61115  ? 11  ALA A C   1 
ATOM   82   O O   . ALA A 1 11  ? 7.41063   9.82410   27.26004  1.000 22.58160  ? 11  ALA A O   1 
ATOM   83   C CB  . ALA A 1 11  ? 8.06199   12.94596  28.08195  1.000 29.37297  ? 11  ALA A CB  1 
ATOM   84   N N   . ASN A 1 12  ? 8.67025   10.02158  29.13513  1.000 20.50986  ? 12  ASN A N   1 
ATOM   85   C CA  . ASN A 1 12  ? 9.49480   8.84247   28.84754  1.000 22.44811  ? 12  ASN A CA  1 
ATOM   86   C C   . ASN A 1 12  ? 9.26635   7.66568   29.77522  1.000 20.57439  ? 12  ASN A C   1 
ATOM   87   O O   . ASN A 1 12  ? 9.77770   6.57923   29.48372  1.000 19.62814  ? 12  ASN A O   1 
ATOM   88   C CB  . ASN A 1 12  ? 10.99802  9.18170   28.93501  1.000 21.47437  ? 12  ASN A CB  1 
ATOM   89   C CG  . ASN A 1 12  ? 11.35372  10.42542  28.18557  1.000 29.97767  ? 12  ASN A CG  1 
ATOM   90   O OD1 . ASN A 1 12  ? 11.95292  11.38200  28.73602  1.000 23.45423  ? 12  ASN A OD1 1 
ATOM   91   N ND2 . ASN A 1 12  ? 11.01256  10.42565  26.90864  1.000 20.83533  ? 12  ASN A ND2 1 
ATOM   92   N N   . GLY A 1 13  ? 8.58066   7.85676   30.90980  1.000 19.43990  ? 13  GLY A N   1 
ATOM   93   C CA  . GLY A 1 13  ? 8.33397   6.77703   31.85648  1.000 17.29814  ? 13  GLY A CA  1 
ATOM   94   C C   . GLY A 1 13  ? 9.41219   6.56679   32.91397  1.000 15.94916  ? 13  GLY A C   1 
ATOM   95   O O   . GLY A 1 13  ? 9.18270   5.78328   33.84645  1.000 14.28982  ? 13  GLY A O   1 
ATOM   96   N N   . TYR A 1 14  ? 10.55364  7.26831   32.82802  1.000 15.21395  ? 14  TYR A N   1 
ATOM   97   C CA  . TYR A 1 14  ? 11.65362  7.08611   33.77783  1.000 18.96008  ? 14  TYR A CA  1 
ATOM   98   C C   . TYR A 1 14  ? 12.52231  8.33772   33.74206  1.000 20.41682  ? 14  TYR A C   1 
ATOM   99   O O   . TYR A 1 14  ? 12.44025  9.15492   32.82172  1.000 17.66531  ? 14  TYR A O   1 
ATOM   100  C CB  . TYR A 1 14  ? 12.50173  5.83057   33.45403  1.000 13.59540  ? 14  TYR A CB  1 
ATOM   101  C CG  . TYR A 1 14  ? 13.34328  6.03230   32.19731  1.000 13.73006  ? 14  TYR A CG  1 
ATOM   102  C CD1 . TYR A 1 14  ? 12.79350  5.83287   30.93951  1.000 18.65595  ? 14  TYR A CD1 1 
ATOM   103  C CD2 . TYR A 1 14  ? 14.66359  6.48597   32.27423  1.000 17.60772  ? 14  TYR A CD2 1 
ATOM   104  C CE1 . TYR A 1 14  ? 13.54910  6.04519   29.75989  1.000 17.74754  ? 14  TYR A CE1 1 
ATOM   105  C CE2 . TYR A 1 14  ? 15.41978  6.72578   31.11279  1.000 22.77641  ? 14  TYR A CE2 1 
ATOM   106  C CZ  . TYR A 1 14  ? 14.84752  6.50644   29.85741  1.000 21.72005  ? 14  TYR A CZ  1 
ATOM   107  O OH  . TYR A 1 14  ? 15.59674  6.73378   28.71201  1.000 19.46458  ? 14  TYR A OH  1 
ATOM   108  N N   . SER A 1 15  ? 13.31973  8.51759   34.78392  1.000 12.64810  ? 15  SER A N   1 
ATOM   109  C CA  . SER A 1 15  ? 14.18051  9.68954   34.87776  1.000 15.75225  ? 15  SER A CA  1 
ATOM   110  C C   . SER A 1 15  ? 15.40688  9.28421   35.67952  1.000 15.28737  ? 15  SER A C   1 
ATOM   111  O O   . SER A 1 15  ? 15.27632  8.60808   36.70606  1.000 16.01430  ? 15  SER A O   1 
ATOM   112  C CB  . SER A 1 15  ? 13.44972  10.87869  35.53846  1.000 16.48222  ? 15  SER A CB  1 
ATOM   113  O OG  . SER A 1 15  ? 14.33011  11.98587  35.68727  1.000 18.82244  ? 15  SER A OG  1 
ATOM   114  N N   . LEU A 1 16  ? 16.59430  9.69165   35.22738  1.000 15.29834  ? 16  LEU A N   1 
ATOM   115  C CA  . LEU A 1 16  ? 17.84238  9.27538   35.87922  1.000 16.30415  ? 16  LEU A CA  1 
ATOM   116  C C   . LEU A 1 16  ? 18.42656  10.41355  36.68737  1.000 18.81792  ? 16  LEU A C   1 
ATOM   117  O O   . LEU A 1 16  ? 18.38430  11.56983  36.25843  1.000 21.01079  ? 16  LEU A O   1 
ATOM   118  C CB  . LEU A 1 16  ? 18.88692  8.80438   34.85154  1.000 14.71351  ? 16  LEU A CB  1 
ATOM   119  C CG  . LEU A 1 16  ? 18.31255  7.72748   33.95237  1.000 19.05527  ? 16  LEU A CG  1 
ATOM   120  C CD1 . LEU A 1 16  ? 19.32405  7.31461   32.93693  1.000 16.31492  ? 16  LEU A CD1 1 
ATOM   121  C CD2 . LEU A 1 16  ? 17.98339  6.54114   34.86112  1.000 19.76911  ? 16  LEU A CD2 1 
ATOM   122  N N   . LEU A 1 17  ? 18.99712  10.09115  37.84452  1.000 15.05615  ? 17  LEU A N   1 
ATOM   123  C CA  . LEU A 1 17  ? 19.59174  11.10766  38.71494  1.000 14.47248  ? 17  LEU A CA  1 
ATOM   124  C C   . LEU A 1 17  ? 20.92451  10.59246  39.26809  1.000 18.89688  ? 17  LEU A C   1 
ATOM   125  O O   . LEU A 1 17  ? 20.96824  9.92973   40.30866  1.000 19.10003  ? 17  LEU A O   1 
ATOM   126  C CB  . LEU A 1 17  ? 18.62931  11.49787  39.84764  1.000 14.35014  ? 17  LEU A CB  1 
ATOM   127  C CG  . LEU A 1 17  ? 19.15642  12.48710  40.90671  1.000 22.79747  ? 17  LEU A CG  1 
ATOM   128  C CD1 . LEU A 1 17  ? 19.62536  13.74744  40.21254  1.000 30.80013  ? 17  LEU A CD1 1 
ATOM   129  C CD2 . LEU A 1 17  ? 18.16856  12.80995  42.08050  1.000 18.39675  ? 17  LEU A CD2 1 
ATOM   130  N N   . PRO A 1 18  ? 22.03297  10.88146  38.59166  1.000 17.60220  ? 18  PRO A N   1 
ATOM   131  C CA  . PRO A 1 18  ? 23.32348  10.37696  39.05365  1.000 16.72121  ? 18  PRO A CA  1 
ATOM   132  C C   . PRO A 1 18  ? 23.75482  11.13157  40.29611  1.000 18.43861  ? 18  PRO A C   1 
ATOM   133  O O   . PRO A 1 18  ? 23.38167  12.28172  40.50770  1.000 23.31758  ? 18  PRO A O   1 
ATOM   134  C CB  . PRO A 1 18  ? 24.25656  10.63095  37.87182  1.000 18.27687  ? 18  PRO A CB  1 
ATOM   135  C CG  . PRO A 1 18  ? 23.57478  11.82380  37.12305  1.000 25.41075  ? 18  PRO A CG  1 
ATOM   136  C CD  . PRO A 1 18  ? 22.11497  11.62240  37.31579  1.000 21.63479  ? 18  PRO A CD  1 
ATOM   137  N N   . ALA A 1 19  ? 24.53041  10.44779  41.13395  1.000 18.75594  ? 19  ALA A N   1 
ATOM   138  C CA  . ALA A 1 19  ? 24.92933  11.01768  42.42738  1.000 25.70682  ? 19  ALA A CA  1 
ATOM   139  C C   . ALA A 1 19  ? 25.78446  12.26154  42.26808  1.000 30.78560  ? 19  ALA A C   1 
ATOM   140  O O   . ALA A 1 19  ? 25.82172  13.10664  43.16321  1.000 29.85865  ? 19  ALA A O   1 
ATOM   141  C CB  . ALA A 1 19  ? 25.72677  9.99175   43.21571  1.000 25.25913  ? 19  ALA A CB  1 
ATOM   142  N N   . ASP A 1 20  ? 26.48228  12.36348  41.13589  1.000 29.28972  ? 20  ASP A N   1 
ATOM   143  C CA  . ASP A 1 20  ? 27.46608  13.40944  40.89699  1.000 42.25003  ? 20  ASP A CA  1 
ATOM   144  C C   . ASP A 1 20  ? 26.89248  14.81623  41.09313  1.000 44.08038  ? 20  ASP A C   1 
ATOM   145  O O   . ASP A 1 20  ? 27.60555  15.71270  41.55843  1.000 62.35851  ? 20  ASP A O   1 
ATOM   146  C CB  . ASP A 1 20  ? 28.04414  13.21442  39.48835  1.000 32.36449  ? 20  ASP A CB  1 
ATOM   147  C CG  . ASP A 1 20  ? 29.40893  13.84224  39.33121  1.000 55.53397  ? 20  ASP A CG  1 
ATOM   148  O OD1 . ASP A 1 20  ? 29.50907  15.08198  39.43870  1.000 61.89164  ? 20  ASP A OD1 1 
ATOM   149  O OD2 . ASP A 1 20  ? 30.39107  13.09728  39.11189  1.000 68.31601  ? 20  ASP A OD2 1 
ATOM   150  N N   . ARG A 1 21  ? 25.61497  15.03783  40.78028  1.000 46.89312  ? 21  ARG A N   1 
ATOM   151  C CA  . ARG A 1 21  ? 25.03137  16.34842  41.08204  1.000 57.76127  ? 21  ARG A CA  1 
ATOM   152  C C   . ARG A 1 21  ? 24.59703  16.38703  42.54509  1.000 57.95392  ? 21  ARG A C   1 
ATOM   153  O O   . ARG A 1 21  ? 23.47041  16.03616  42.89234  1.000 55.16583  ? 21  ARG A O   1 
ATOM   154  C CB  . ARG A 1 21  ? 23.87776  16.66829  40.14501  1.000 56.94666  ? 21  ARG A CB  1 
ATOM   155  C CG  . ARG A 1 21  ? 22.97221  15.52814  39.84067  1.000 41.98850  ? 21  ARG A CG  1 
ATOM   156  C CD  . ARG A 1 21  ? 23.03936  15.22152  38.37530  1.000 47.91315  ? 21  ARG A CD  1 
ATOM   157  N NE  . ARG A 1 21  ? 22.80952  16.39777  37.54527  1.000 62.68989  ? 21  ARG A NE  1 
ATOM   158  C CZ  . ARG A 1 21  ? 21.61341  16.84004  37.17133  1.000 74.43603  ? 21  ARG A CZ  1 
ATOM   159  N NH1 . ARG A 1 21  ? 20.49977  16.22247  37.53376  1.000 71.84061  ? 21  ARG A NH1 1 
ATOM   160  N NH2 . ARG A 1 21  ? 21.53342  17.92999  36.41053  1.000 83.95932  ? 21  ARG A NH2 1 
ATOM   161  N N   . LEU A 1 22  ? 25.51381  16.86070  43.40325  1.000 73.65166  ? 22  LEU A N   1 
ATOM   162  C CA  . LEU A 1 22  ? 25.39149  16.86928  44.86165  1.000 65.27679  ? 22  LEU A CA  1 
ATOM   163  C C   . LEU A 1 22  ? 25.08083  15.48673  45.39894  1.000 81.75774  ? 22  LEU A C   1 
ATOM   164  O O   . LEU A 1 22  ? 23.93189  15.02202  45.33536  1.000 78.05831  ? 22  LEU A O   1 
ATOM   165  C CB  . LEU A 1 22  ? 24.32527  17.84708  45.35140  1.000 73.09068  ? 22  LEU A CB  1 
ATOM   166  C CG  . LEU A 1 22  ? 24.00425  17.83914  46.85308  1.000 71.46247  ? 22  LEU A CG  1 
ATOM   167  C CD1 . LEU A 1 22  ? 25.25420  17.74331  47.75348  1.000 69.82488  ? 22  LEU A CD1 1 
ATOM   168  C CD2 . LEU A 1 22  ? 23.18979  19.09339  47.17069  1.000 65.24690  ? 22  LEU A CD2 1 
ATOM   169  N N   . VAL A 1 23  ? 26.10894  14.83762  45.94189  1.000 94.93601  ? 23  VAL A N   1 
ATOM   170  C CA  . VAL A 1 23  ? 25.92328  13.58413  46.66326  1.000 92.36146  ? 23  VAL A CA  1 
ATOM   171  C C   . VAL A 1 23  ? 25.69820  13.82940  48.15215  1.000 88.95180  ? 23  VAL A C   1 
ATOM   172  O O   . VAL A 1 23  ? 24.79137  13.23476  48.73911  1.000 90.59987  ? 23  VAL A O   1 
ATOM   173  C CB  . VAL A 1 23  ? 27.11689  12.63567  46.41563  1.000 87.65351  ? 23  VAL A CB  1 
ATOM   174  C CG1 . VAL A 1 23  ? 28.45031  13.36727  46.59765  1.000 98.27724  ? 23  VAL A CG1 1 
ATOM   175  C CG2 . VAL A 1 23  ? 27.02982  11.41156  47.32276  1.000 83.84845  ? 23  VAL A CG2 1 
ATOM   176  N N   . ILE A 1 24  ? 26.47334  14.72882  48.77978  1.000 84.80289  ? 24  ILE A N   1 
ATOM   177  C CA  . ILE A 1 24  ? 26.40254  14.86773  50.23010  1.000 75.54416  ? 24  ILE A CA  1 
ATOM   178  C C   . ILE A 1 24  ? 27.35359  15.89758  50.83035  1.000 66.90883  ? 24  ILE A C   1 
ATOM   179  O O   . ILE A 1 24  ? 28.51609  16.00120  50.42455  1.000 64.78989  ? 24  ILE A O   1 
ATOM   180  C CB  . ILE A 1 24  ? 26.69234  13.51637  50.89890  1.000 67.18062  ? 24  ILE A CB  1 
ATOM   181  N N   . ASP A 1 25  ? 26.87265  16.61827  51.84268  1.000 60.13644  ? 25  ASP A N   1 
ATOM   182  C CA  . ASP A 1 25  ? 27.74060  17.17929  52.86528  1.000 55.75842  ? 25  ASP A CA  1 
ATOM   183  C C   . ASP A 1 25  ? 28.16967  16.08163  53.84207  1.000 56.61029  ? 25  ASP A C   1 
ATOM   184  O O   . ASP A 1 25  ? 27.80112  14.90504  53.71054  1.000 49.79592  ? 25  ASP A O   1 
ATOM   185  C CB  . ASP A 1 25  ? 27.03432  18.31543  53.59864  1.000 54.14799  ? 25  ASP A CB  1 
ATOM   186  C CG  . ASP A 1 25  ? 25.69981  17.89325  54.19910  1.000 60.20066  ? 25  ASP A CG  1 
ATOM   187  O OD1 . ASP A 1 25  ? 25.65985  16.92378  55.00115  1.000 54.13552  ? 25  ASP A OD1 1 
ATOM   188  O OD2 . ASP A 1 25  ? 24.68781  18.55218  53.87454  1.000 69.94149  ? 25  ASP A OD2 1 
ATOM   189  N N   . ALA A 1 26  ? 28.92027  16.48458  54.86875  1.000 45.33913  ? 26  ALA A N   1 
ATOM   190  C CA  . ALA A 1 26  ? 29.49456  15.52034  55.79987  1.000 42.98222  ? 26  ALA A CA  1 
ATOM   191  C C   . ALA A 1 26  ? 28.42009  14.68487  56.48985  1.000 41.62272  ? 26  ALA A C   1 
ATOM   192  O O   . ALA A 1 26  ? 28.54562  13.45906  56.58344  1.000 40.13338  ? 26  ALA A O   1 
ATOM   193  C CB  . ALA A 1 26  ? 30.35599  16.24622  56.83613  1.000 47.78726  ? 26  ALA A CB  1 
ATOM   194  N N   . GLU A 1 27  ? 27.37032  15.33071  57.00958  1.000 43.16122  ? 27  GLU A N   1 
ATOM   195  C CA  . GLU A 1 27  ? 26.34865  14.60358  57.76146  1.000 46.77701  ? 27  GLU A CA  1 
ATOM   196  C C   . GLU A 1 27  ? 25.62577  13.60075  56.87207  1.000 39.63381  ? 27  GLU A C   1 
ATOM   197  O O   . GLU A 1 27  ? 25.45981  12.42722  57.23416  1.000 35.59679  ? 27  GLU A O   1 
ATOM   198  C CB  . GLU A 1 27  ? 25.33156  15.56845  58.35788  1.000 51.89461  ? 27  GLU A CB  1 
ATOM   199  C CG  . GLU A 1 27  ? 25.82428  16.40017  59.50259  1.000 71.17647  ? 27  GLU A CG  1 
ATOM   200  C CD  . GLU A 1 27  ? 24.76188  17.37271  59.98900  1.000 92.39358  ? 27  GLU A CD  1 
ATOM   201  O OE1 . GLU A 1 27  ? 23.75131  17.56878  59.26628  1.000 83.36924  ? 27  GLU A OE1 1 
ATOM   202  O OE2 . GLU A 1 27  ? 24.93900  17.93455  61.09506  1.000 96.00522  ? 27  GLU A OE2 1 
ATOM   203  N N   . LEU A 1 28  ? 25.14981  14.06870  55.71953  1.000 36.24677  ? 28  LEU A N   1 
ATOM   204  C CA  . LEU A 1 28  ? 24.46937  13.18780  54.79002  1.000 36.12697  ? 28  LEU A CA  1 
ATOM   205  C C   . LEU A 1 28  ? 25.37459  12.03276  54.40411  1.000 34.38084  ? 28  LEU A C   1 
ATOM   206  O O   . LEU A 1 28  ? 24.96625  10.87491  54.46176  1.000 25.41307  ? 28  LEU A O   1 
ATOM   207  C CB  . LEU A 1 28  ? 24.03629  13.96188  53.55395  1.000 39.10885  ? 28  LEU A CB  1 
ATOM   208  C CG  . LEU A 1 28  ? 23.37071  13.07500  52.48920  1.000 43.25286  ? 28  LEU A CG  1 
ATOM   209  C CD1 . LEU A 1 28  ? 22.14222  12.33966  53.07979  1.000 29.23802  ? 28  LEU A CD1 1 
ATOM   210  C CD2 . LEU A 1 28  ? 22.98565  13.90325  51.28961  1.000 43.69684  ? 28  LEU A CD2 1 
ATOM   211  N N   . ARG A 1 29  ? 26.62873  12.34226  54.05852  1.000 35.03633  ? 29  ARG A N   1 
ATOM   212  C CA  . ARG A 1 29  ? 27.60472  11.33216  53.66577  1.000 32.25955  ? 29  ARG A CA  1 
ATOM   213  C C   . ARG A 1 29  ? 27.67048  10.19287  54.66898  1.000 30.19749  ? 29  ARG A C   1 
ATOM   214  O O   . ARG A 1 29  ? 27.67748  9.01579   54.28951  1.000 27.55462  ? 29  ARG A O   1 
ATOM   215  C CB  . ARG A 1 29  ? 28.98035  11.98893  53.50050  1.000 39.33665  ? 29  ARG A CB  1 
ATOM   216  C CG  . ARG A 1 29  ? 30.06783  11.09713  52.89975  1.000 48.07490  ? 29  ARG A CG  1 
ATOM   217  C CD  . ARG A 1 29  ? 31.32885  11.90842  52.50374  1.000 67.07839  ? 29  ARG A CD  1 
ATOM   218  N NE  . ARG A 1 29  ? 31.15666  12.68256  51.27316  1.000 72.32435  ? 29  ARG A NE  1 
ATOM   219  C CZ  . ARG A 1 29  ? 31.07983  14.00714  51.21063  1.000 72.22948  ? 29  ARG A CZ  1 
ATOM   220  N NH1 . ARG A 1 29  ? 31.20260  14.76210  52.29101  1.000 70.14775  ? 29  ARG A NH1 1 
ATOM   221  N NH2 . ARG A 1 29  ? 30.87178  14.59002  50.03335  1.000 73.82374  ? 29  ARG A NH2 1 
ATOM   222  N N   . GLN A 1 30  ? 27.72112  10.52998  55.96396  1.000 27.46811  ? 30  GLN A N   1 
ATOM   223  C CA  . GLN A 1 30  ? 27.85134  9.51046   56.98786  1.000 29.40425  ? 30  GLN A CA  1 
ATOM   224  C C   . GLN A 1 30  ? 26.60104  8.62574   57.06662  1.000 23.64332  ? 30  GLN A C   1 
ATOM   225  O O   . GLN A 1 30  ? 26.70165  7.40411   57.26536  1.000 23.16377  ? 30  GLN A O   1 
ATOM   226  C CB  . GLN A 1 30  ? 28.10565  10.18798  58.32417  1.000 32.73231  ? 30  GLN A CB  1 
ATOM   227  C CG  . GLN A 1 30  ? 28.12559  9.23440   59.51419  1.000 40.45178  ? 30  GLN A CG  1 
ATOM   228  C CD  . GLN A 1 30  ? 29.30558  8.26298   59.49378  1.000 47.21519  ? 30  GLN A CD  1 
ATOM   229  O OE1 . GLN A 1 30  ? 30.34231  8.51735   58.85615  1.000 47.91745  ? 30  GLN A OE1 1 
ATOM   230  N NE2 . GLN A 1 30  ? 29.15127  7.13919   60.21007  1.000 43.85442  ? 30  GLN A NE2 1 
ATOM   231  N N   . HIS A 1 31  ? 25.42008  9.23890   56.98755  1.000 21.20963  ? 31  HIS A N   1 
ATOM   232  C CA  . HIS A 1 31  ? 24.17673  8.47040   56.94485  1.000 23.31258  ? 31  HIS A CA  1 
ATOM   233  C C   . HIS A 1 31  ? 24.15046  7.52779   55.75549  1.000 20.41925  ? 31  HIS A C   1 
ATOM   234  O O   . HIS A 1 31  ? 23.64142  6.40415   55.86124  1.000 18.61798  ? 31  HIS A O   1 
ATOM   235  C CB  . HIS A 1 31  ? 22.97526  9.41176   56.88857  1.000 25.16645  ? 31  HIS A CB  1 
ATOM   236  C CG  . HIS A 1 31  ? 22.70592  10.10514  58.18687  1.000 18.24834  ? 31  HIS A CG  1 
ATOM   237  N ND1 . HIS A 1 31  ? 22.76421  9.45366   59.39585  1.000 30.25973  ? 31  HIS A ND1 1 
ATOM   238  C CD2 . HIS A 1 31  ? 22.46600  11.40452  58.47009  1.000 31.68614  ? 31  HIS A CD2 1 
ATOM   239  C CE1 . HIS A 1 31  ? 22.51918  10.31321  60.36902  1.000 32.27329  ? 31  HIS A CE1 1 
ATOM   240  N NE2 . HIS A 1 31  ? 22.34332  11.50759  59.83311  1.000 33.98487  ? 31  HIS A NE2 1 
ATOM   241  N N   . VAL A 1 32  ? 24.64191  7.98372   54.59865  1.000 18.22092  ? 32  VAL A N   1 
ATOM   242  C CA  . VAL A 1 32  ? 24.64160  7.11624   53.42820  1.000 15.72840  ? 32  VAL A CA  1 
ATOM   243  C C   . VAL A 1 32  ? 25.52758  5.90330   53.68717  1.000 20.60259  ? 32  VAL A C   1 
ATOM   244  O O   . VAL A 1 32  ? 25.16061  4.76414   53.37848  1.000 18.85032  ? 32  VAL A O   1 
ATOM   245  C CB  . VAL A 1 32  ? 25.09842  7.88414   52.17044  1.000 16.48352  ? 32  VAL A CB  1 
ATOM   246  C CG1 . VAL A 1 32  ? 25.23626  6.93308   50.98710  1.000 22.06220  ? 32  VAL A CG1 1 
ATOM   247  C CG2 . VAL A 1 32  ? 24.12191  9.00907   51.76880  1.000 19.67426  ? 32  VAL A CG2 1 
ATOM   248  N N   . LYS A 1 33  ? 26.72873  6.13449   54.23496  1.000 21.33325  ? 33  LYS A N   1 
ATOM   249  C CA  . LYS A 1 33  ? 27.60647  5.00598   54.56580  1.000 19.26166  ? 33  LYS A CA  1 
ATOM   250  C C   . LYS A 1 33  ? 26.95276  4.05824   55.56236  1.000 18.99708  ? 33  LYS A C   1 
ATOM   251  O O   . LYS A 1 33  ? 27.05064  2.83470   55.41415  1.000 19.05481  ? 33  LYS A O   1 
ATOM   252  C CB  . LYS A 1 33  ? 28.92668  5.50079   55.17909  1.000 27.21894  ? 33  LYS A CB  1 
ATOM   253  C CG  . LYS A 1 33  ? 29.60499  6.59297   54.41308  1.000 34.93637  ? 33  LYS A CG  1 
ATOM   254  C CD  . LYS A 1 33  ? 30.54721  6.03531   53.36956  1.000 59.16601  ? 33  LYS A CD  1 
ATOM   255  C CE  . LYS A 1 33  ? 29.86455  5.97716   52.01240  1.000 39.36759  ? 33  LYS A CE  1 
ATOM   256  N NZ  . LYS A 1 33  ? 30.85742  5.89558   50.91330  1.000 37.49970  ? 33  LYS A NZ  1 
ATOM   257  N N   . GLU A 1 34  ? 26.31799  4.61059   56.60553  1.000 19.94883  ? 34  GLU A N   1 
ATOM   258  C CA  . GLU A 1 34  ? 25.63391  3.78441   57.59275  1.000 20.33853  ? 34  GLU A CA  1 
ATOM   259  C C   . GLU A 1 34  ? 24.49975  3.00465   56.94771  1.000 20.68350  ? 34  GLU A C   1 
ATOM   260  O O   . GLU A 1 34  ? 24.26598  1.84327   57.29105  1.000 18.62074  ? 34  GLU A O   1 
ATOM   261  C CB  . GLU A 1 34  ? 25.05482  4.64440   58.72496  1.000 25.42009  ? 34  GLU A CB  1 
ATOM   262  C CG  . GLU A 1 34  ? 26.06390  5.37997   59.60799  1.000 31.07878  ? 34  GLU A CG  1 
ATOM   263  C CD  . GLU A 1 34  ? 25.40056  6.49618   60.44685  1.000 40.30670  ? 34  GLU A CD  1 
ATOM   264  O OE1 . GLU A 1 34  ? 24.15992  6.69726   60.38229  1.000 31.90615  ? 34  GLU A OE1 1 
ATOM   265  O OE2 . GLU A 1 34  ? 26.13707  7.21257   61.14737  1.000 43.35869  ? 34  GLU A OE2 1 
ATOM   266  N N   . LEU A 1 35  ? 23.75226  3.64070   56.04698  1.000 15.30501  ? 35  LEU A N   1 
ATOM   267  C CA  . LEU A 1 35  ? 22.67449  2.90506   55.39167  1.000 18.73993  ? 35  LEU A CA  1 
ATOM   268  C C   . LEU A 1 35  ? 23.26129  1.81678   54.50607  1.000 14.86624  ? 35  LEU A C   1 
ATOM   269  O O   . LEU A 1 35  ? 22.88174  0.64504   54.61932  1.000 14.31593  ? 35  LEU A O   1 
ATOM   270  C CB  . LEU A 1 35  ? 21.77752  3.85803   54.57297  1.000 16.23647  ? 35  LEU A CB  1 
ATOM   271  C CG  . LEU A 1 35  ? 20.53845  3.21865   53.94428  1.000 15.66538  ? 35  LEU A CG  1 
ATOM   272  C CD1 . LEU A 1 35  ? 19.67486  2.53062   55.00089  1.000 16.00355  ? 35  LEU A CD1 1 
ATOM   273  C CD2 . LEU A 1 35  ? 19.72309  4.33390   53.20751  1.000 19.69265  ? 35  LEU A CD2 1 
ATOM   274  N N   . ALA A 1 36  ? 24.22777  2.17793   53.64907  1.000 14.04928  ? 36  ALA A N   1 
ATOM   275  C CA  . ALA A 1 36  ? 24.78569  1.16326   52.74680  1.000 14.50834  ? 36  ALA A CA  1 
ATOM   276  C C   . ALA A 1 36  ? 25.38408  -0.02340  53.49922  1.000 16.59453  ? 36  ALA A C   1 
ATOM   277  O O   . ALA A 1 36  ? 25.34756  -1.16832  52.98681  1.000 18.19040  ? 36  ALA A O   1 
ATOM   278  C CB  . ALA A 1 36  ? 25.86671  1.75304   51.83032  1.000 15.64834  ? 36  ALA A CB  1 
ATOM   279  N N   . ALA A 1 37  ? 25.91176  0.20978   54.71362  1.000 19.05466  ? 37  ALA A N   1 
ATOM   280  C CA  . ALA A 1 37  ? 26.50931  -0.88317  55.50389  1.000 19.49338  ? 37  ALA A CA  1 
ATOM   281  C C   . ALA A 1 37  ? 25.49786  -1.95170  55.92277  1.000 22.12734  ? 37  ALA A C   1 
ATOM   282  O O   . ALA A 1 37  ? 25.89017  -3.10404  56.20407  1.000 18.81497  ? 37  ALA A O   1 
ATOM   283  C CB  . ALA A 1 37  ? 27.20884  -0.29174  56.74421  1.000 21.60317  ? 37  ALA A CB  1 
ATOM   284  N N   . GLU A 1 38  ? 24.20243  -1.61287  55.96793  1.000 15.50833  ? 38  GLU A N   1 
ATOM   285  C CA  . GLU A 1 38  ? 23.17548  -2.60826  56.32614  1.000 13.13664  ? 38  GLU A CA  1 
ATOM   286  C C   . GLU A 1 38  ? 23.15590  -3.78160  55.36833  1.000 19.07847  ? 38  GLU A C   1 
ATOM   287  O O   . GLU A 1 38  ? 22.71063  -4.89009  55.73849  1.000 19.25467  ? 38  GLU A O   1 
ATOM   288  C CB  . GLU A 1 38  ? 21.78781  -1.94894  56.33272  1.000 14.97793  ? 38  GLU A CB  1 
ATOM   289  C CG  . GLU A 1 38  ? 21.71880  -0.79680  57.29239  1.000 19.87006  ? 38  GLU A CG  1 
ATOM   290  C CD  . GLU A 1 38  ? 21.69318  -1.25749  58.73779  1.000 25.51185  ? 38  GLU A CD  1 
ATOM   291  O OE1 . GLU A 1 38  ? 21.39681  -2.45177  59.03226  1.000 19.71826  ? 38  GLU A OE1 1 
ATOM   292  O OE2 . GLU A 1 38  ? 21.94827  -0.39100  59.59750  1.000 30.10819  ? 38  GLU A OE2 1 
ATOM   293  N N   . TRP A 1 39  ? 23.58233  -3.56238  54.12430  1.000 15.41281  ? 39  TRP A N   1 
ATOM   294  C CA  . TRP A 1 39  ? 23.52651  -4.65556  53.15268  1.000 16.31367  ? 39  TRP A CA  1 
ATOM   295  C C   . TRP A 1 39  ? 24.53461  -5.76145  53.47885  1.000 20.15482  ? 39  TRP A C   1 
ATOM   296  O O   . TRP A 1 39  ? 24.44288  -6.84047  52.90084  1.000 16.57921  ? 39  TRP A O   1 
ATOM   297  C CB  . TRP A 1 39  ? 23.77486  -4.10441  51.72796  1.000 14.13076  ? 39  TRP A CB  1 
ATOM   298  C CG  . TRP A 1 39  ? 22.53879  -3.55418  51.00315  1.000 13.40639  ? 39  TRP A CG  1 
ATOM   299  C CD1 . TRP A 1 39  ? 21.96226  -4.07356  49.89509  1.000 15.90504  ? 39  TRP A CD1 1 
ATOM   300  C CD2 . TRP A 1 39  ? 21.73213  -2.39967  51.36857  1.000 12.11673  ? 39  TRP A CD2 1 
ATOM   301  N NE1 . TRP A 1 39  ? 20.84667  -3.32009  49.51750  1.000 15.01968  ? 39  TRP A NE1 1 
ATOM   302  C CE2 . TRP A 1 39  ? 20.70414  -2.27483  50.39052  1.000 11.97490  ? 39  TRP A CE2 1 
ATOM   303  C CE3 . TRP A 1 39  ? 21.82360  -1.42979  52.36378  1.000 12.63604  ? 39  TRP A CE3 1 
ATOM   304  C CZ2 . TRP A 1 39  ? 19.71679  -1.24546  50.42353  1.000 13.97258  ? 39  TRP A CZ2 1 
ATOM   305  C CZ3 . TRP A 1 39  ? 20.80851  -0.38356  52.39435  1.000 10.59553  ? 39  TRP A CZ3 1 
ATOM   306  C CH2 . TRP A 1 39  ? 19.79440  -0.31990  51.42504  1.000 13.60586  ? 39  TRP A CH2 1 
ATOM   307  N N   . GLU A 1 40  ? 25.48665  -5.51165  54.37418  1.000 19.47264  ? 40  GLU A N   1 
ATOM   308  C CA  . GLU A 1 40  ? 26.40897  -6.55210  54.83728  1.000 23.76915  ? 40  GLU A CA  1 
ATOM   309  C C   . GLU A 1 40  ? 25.74169  -7.57368  55.75457  1.000 28.96363  ? 40  GLU A C   1 
ATOM   310  O O   . GLU A 1 40  ? 26.34116  -8.62185  56.04645  1.000 27.20224  ? 40  GLU A O   1 
ATOM   311  C CB  . GLU A 1 40  ? 27.60371  -5.92233  55.58633  1.000 21.75778  ? 40  GLU A CB  1 
ATOM   312  C CG  . GLU A 1 40  ? 28.54684  -5.07884  54.70048  1.000 24.19784  ? 40  GLU A CG  1 
ATOM   313  C CD  . GLU A 1 40  ? 29.05657  -5.82201  53.43620  1.000 28.37794  ? 40  GLU A CD  1 
ATOM   314  O OE1 . GLU A 1 40  ? 29.19084  -7.06391  53.48980  1.000 37.30777  ? 40  GLU A OE1 1 
ATOM   315  O OE2 . GLU A 1 40  ? 29.30765  -5.17695  52.37399  1.000 31.07587  ? 40  GLU A OE2 1 
ATOM   316  N N   . ASN A 1 41  ? 24.53483  -7.30358  56.22226  1.000 26.25254  ? 41  ASN A N   1 
ATOM   317  C CA  . ASN A 1 41  ? 23.88889  -8.09020  57.27179  1.000 26.69374  ? 41  ASN A CA  1 
ATOM   318  C C   . ASN A 1 41  ? 22.50292  -8.56117  56.88345  1.000 27.98400  ? 41  ASN A C   1 
ATOM   319  O O   . ASN A 1 41  ? 21.60679  -8.60248  57.71735  1.000 27.47391  ? 41  ASN A O   1 
ATOM   320  C CB  . ASN A 1 41  ? 23.81480  -7.28087  58.56874  1.000 25.21127  ? 41  ASN A CB  1 
ATOM   321  C CG  . ASN A 1 41  ? 25.19179  -6.88776  59.07493  1.000 44.09563  ? 41  ASN A CG  1 
ATOM   322  O OD1 . ASN A 1 41  ? 25.48562  -5.69002  59.28488  1.000 61.25943  ? 41  ASN A OD1 1 
ATOM   323  N ND2 . ASN A 1 41  ? 26.08040  -7.88786  59.23085  1.000 45.58081  ? 41  ASN A ND2 1 
ATOM   324  N N   . LEU A 1 42  ? 22.30150  -8.90509  55.62330  1.000 24.41848  ? 42  LEU A N   1 
ATOM   325  C CA  . LEU A 1 42  ? 20.98420  -9.28065  55.14273  1.000 24.81497  ? 42  LEU A CA  1 
ATOM   326  C C   . LEU A 1 42  ? 20.80748  -10.78432 55.21531  1.000 35.38912  ? 42  LEU A C   1 
ATOM   327  O O   . LEU A 1 42  ? 21.76226  -11.55371 55.07568  1.000 35.96335  ? 42  LEU A O   1 
ATOM   328  C CB  . LEU A 1 42  ? 20.73403  -8.83273  53.69611  1.000 19.49708  ? 42  LEU A CB  1 
ATOM   329  C CG  . LEU A 1 42  ? 20.74532  -7.31048  53.49807  1.000 21.74008  ? 42  LEU A CG  1 
ATOM   330  C CD1 . LEU A 1 42  ? 20.63782  -6.96796  52.03260  1.000 18.85687  ? 42  LEU A CD1 1 
ATOM   331  C CD2 . LEU A 1 42  ? 19.59047  -6.69128  54.32488  1.000 19.83454  ? 42  LEU A CD2 1 
ATOM   332  N N   . GLU A 1 43  ? 19.56291  -11.19919 55.37363  1.000 35.44892  ? 43  GLU A N   1 
ATOM   333  C CA  . GLU A 1 43  ? 19.28515  -12.62062 55.42701  1.000 48.90356  ? 43  GLU A CA  1 
ATOM   334  C C   . GLU A 1 43  ? 19.34048  -13.23336 54.02992  1.000 48.46958  ? 43  GLU A C   1 
ATOM   335  O O   . GLU A 1 43  ? 18.76285  -12.70669 53.05931  1.000 39.87163  ? 43  GLU A O   1 
ATOM   336  C CB  . GLU A 1 43  ? 17.92677  -12.86862 56.07765  1.000 46.92802  ? 43  GLU A CB  1 
ATOM   337  C CG  . GLU A 1 43  ? 17.78738  -14.22949 56.67957  1.000 55.72301  ? 43  GLU A CG  1 
ATOM   338  C CD  . GLU A 1 43  ? 18.66106  -14.39672 57.90684  1.000 68.18948  ? 43  GLU A CD  1 
ATOM   339  O OE1 . GLU A 1 43  ? 19.15024  -13.36509 58.44055  1.000 67.44395  ? 43  GLU A OE1 1 
ATOM   340  O OE2 . GLU A 1 43  ? 18.84818  -15.55643 58.33644  1.000 72.94708  ? 43  GLU A OE2 1 
ATOM   341  N N   . THR A 1 44  ? 20.03875  -14.36025 53.94892  1.000 59.43955  ? 44  THR A N   1 
ATOM   342  C CA  . THR A 1 44  ? 20.12252  -15.21296 52.77157  1.000 65.80980  ? 44  THR A CA  1 
ATOM   343  C C   . THR A 1 44  ? 18.74914  -15.69933 52.32625  1.000 64.98260  ? 44  THR A C   1 
ATOM   344  O O   . THR A 1 44  ? 18.24077  -16.69429 52.85079  1.000 72.51973  ? 44  THR A O   1 
ATOM   345  C CB  . THR A 1 44  ? 21.03136  -16.39597 53.09270  1.000 73.62482  ? 44  THR A CB  1 
ATOM   346  O OG1 . THR A 1 44  ? 20.79691  -16.80061 54.45533  1.000 71.65984  ? 44  THR A OG1 1 
ATOM   347  C CG2 . THR A 1 44  ? 22.49588  -15.99127 52.91756  1.000 67.76180  ? 44  THR A CG2 1 
ATOM   348  N N   . ASP A 1 45  ? 18.16260  -15.02309 51.34234  1.000 55.25151  ? 45  ASP A N   1 
ATOM   349  C CA  . ASP A 1 45  ? 16.77023  -15.23052 50.95973  1.000 63.18303  ? 45  ASP A CA  1 
ATOM   350  C C   . ASP A 1 45  ? 16.51161  -14.73647 49.53127  1.000 52.70901  ? 45  ASP A C   1 
ATOM   351  O O   . ASP A 1 45  ? 16.56651  -15.50520 48.57391  1.000 65.82098  ? 45  ASP A O   1 
ATOM   352  C CB  . ASP A 1 45  ? 15.83243  -14.49815 51.93832  1.000 69.71036  ? 45  ASP A CB  1 
ATOM   353  C CG  . ASP A 1 45  ? 15.18449  -15.43101 52.98713  1.000 86.62601  ? 45  ASP A CG  1 
ATOM   354  O OD1 . ASP A 1 45  ? 15.40504  -16.66545 52.92086  1.000 93.24556  ? 45  ASP A OD1 1 
ATOM   355  O OD2 . ASP A 1 45  ? 14.43845  -14.92333 53.87555  1.000 67.88376  ? 45  ASP A OD2 1 
ATOM   356  N N   . ARG A 1 53  ? 21.53144  -16.80971 41.19298  1.000 83.14088  ? 53  ARG A N   1 
ATOM   357  C CA  . ARG A 1 53  ? 22.62262  -17.48546 41.89427  1.000 76.54160  ? 53  ARG A CA  1 
ATOM   358  C C   . ARG A 1 53  ? 22.54303  -17.25605 43.41001  1.000 71.46161  ? 53  ARG A C   1 
ATOM   359  O O   . ARG A 1 53  ? 22.43840  -18.21305 44.18067  1.000 90.59601  ? 53  ARG A O   1 
ATOM   360  C CB  . ARG A 1 53  ? 23.97313  -17.01901 41.33946  1.000 65.67444  ? 53  ARG A CB  1 
ATOM   361  C CG  . ARG A 1 53  ? 25.19872  -17.44566 42.15012  1.000 65.13211  ? 53  ARG A CG  1 
ATOM   362  C CD  . ARG A 1 53  ? 25.24912  -18.93422 42.38956  1.000 68.56860  ? 53  ARG A CD  1 
ATOM   363  N NE  . ARG A 1 53  ? 25.34607  -19.69916 41.15517  1.000 81.28942  ? 53  ARG A NE  1 
ATOM   364  C CZ  . ARG A 1 53  ? 25.25508  -21.02096 41.09534  1.000 98.35605  ? 53  ARG A CZ  1 
ATOM   365  N NH1 . ARG A 1 53  ? 25.05165  -21.74937 42.18335  1.000 97.21768  ? 53  ARG A NH1 1 
ATOM   366  N NH2 . ARG A 1 53  ? 25.37390  -21.62865 39.91636  1.000 100.13478 ? 53  ARG A NH2 1 
ATOM   367  N N   . PHE A 1 54  ? 22.57128  -15.99429 43.83905  1.000 56.06910  ? 54  PHE A N   1 
ATOM   368  C CA  . PHE A 1 54  ? 22.57351  -15.67570 45.25875  1.000 42.77316  ? 54  PHE A CA  1 
ATOM   369  C C   . PHE A 1 54  ? 21.90945  -14.31005 45.44954  1.000 37.05824  ? 54  PHE A C   1 
ATOM   370  O O   . PHE A 1 54  ? 22.26090  -13.32377 44.79769  1.000 26.86450  ? 54  PHE A O   1 
ATOM   371  C CB  . PHE A 1 54  ? 24.01559  -15.69310 45.77357  1.000 55.23477  ? 54  PHE A CB  1 
ATOM   372  C CG  . PHE A 1 54  ? 24.17634  -16.09702 47.22056  1.000 57.67303  ? 54  PHE A CG  1 
ATOM   373  C CD1 . PHE A 1 54  ? 23.10747  -16.08678 48.10309  1.000 63.78657  ? 54  PHE A CD1 1 
ATOM   374  C CD2 . PHE A 1 54  ? 25.43938  -16.45670 47.70345  1.000 68.09122  ? 54  PHE A CD2 1 
ATOM   375  C CE1 . PHE A 1 54  ? 23.29017  -16.44031 49.45263  1.000 68.42103  ? 54  PHE A CE1 1 
ATOM   376  C CE2 . PHE A 1 54  ? 25.63066  -16.81502 49.03993  1.000 71.08081  ? 54  PHE A CE2 1 
ATOM   377  C CZ  . PHE A 1 54  ? 24.55521  -16.80550 49.91665  1.000 73.54285  ? 54  PHE A CZ  1 
ATOM   378  N N   . ARG A 1 55  ? 20.90633  -14.25789 46.29760  1.000 29.76517  ? 55  ARG A N   1 
ATOM   379  C CA  . ARG A 1 55  ? 20.18780  -13.01573 46.51525  1.000 28.88578  ? 55  ARG A CA  1 
ATOM   380  C C   . ARG A 1 55  ? 19.90441  -12.95636 48.00401  1.000 30.25021  ? 55  ARG A C   1 
ATOM   381  O O   . ARG A 1 55  ? 19.51704  -13.96622 48.59995  1.000 32.86219  ? 55  ARG A O   1 
ATOM   382  C CB  . ARG A 1 55  ? 18.91163  -12.97110 45.66618  1.000 28.85877  ? 55  ARG A CB  1 
ATOM   383  C CG  . ARG A 1 55  ? 18.19424  -11.62787 45.67426  1.000 46.45145  ? 55  ARG A CG  1 
ATOM   384  C CD  . ARG A 1 55  ? 17.16471  -11.48778 44.52745  1.000 58.34112  ? 55  ARG A CD  1 
ATOM   385  N NE  . ARG A 1 55  ? 15.91031  -12.20235 44.76943  1.000 60.61341  ? 55  ARG A NE  1 
ATOM   386  C CZ  . ARG A 1 55  ? 14.82294  -12.10314 44.01023  1.000 63.88022  ? 55  ARG A CZ  1 
ATOM   387  N NH1 . ARG A 1 55  ? 14.78874  -11.31443 42.94325  1.000 68.63138  ? 55  ARG A NH1 1 
ATOM   388  N NH2 . ARG A 1 55  ? 13.74121  -12.81067 44.33032  1.000 60.44965  ? 55  ARG A NH2 1 
ATOM   389  N N   . GLU A 1 56  ? 20.18696  -11.81073 48.61675  1.000 21.28134  ? 56  GLU A N   1 
ATOM   390  C CA  . GLU A 1 56  ? 19.89621  -11.54997 50.02858  1.000 20.27645  ? 56  GLU A CA  1 
ATOM   391  C C   . GLU A 1 56  ? 19.02229  -10.29955 50.10017  1.000 24.44258  ? 56  GLU A C   1 
ATOM   392  O O   . GLU A 1 56  ? 19.21363  -9.35689  49.30436  1.000 18.61276  ? 56  GLU A O   1 
ATOM   393  C CB  . GLU A 1 56  ? 21.18227  -11.35174 50.83298  1.000 26.30722  ? 56  GLU A CB  1 
ATOM   394  C CG  . GLU A 1 56  ? 22.07682  -12.58470 50.85682  1.000 30.51235  ? 56  GLU A CG  1 
ATOM   395  C CD  . GLU A 1 56  ? 23.44089  -12.34134 51.48279  1.000 38.06647  ? 56  GLU A CD  1 
ATOM   396  O OE1 . GLU A 1 56  ? 23.84265  -11.16314 51.63518  1.000 32.98645  ? 56  GLU A OE1 1 
ATOM   397  O OE2 . GLU A 1 56  ? 24.11997  -13.33102 51.82946  1.000 38.55358  ? 56  GLU A OE2 1 
ATOM   398  N N   . ARG A 1 57  ? 18.06383  -10.27754 51.02910  1.000 17.92311  ? 57  ARG A N   1 
ATOM   399  C CA  . ARG A 1 57  ? 17.11507  -9.17945  50.97447  1.000 18.95220  ? 57  ARG A CA  1 
ATOM   400  C C   . ARG A 1 57  ? 16.40650  -8.99436  52.30537  1.000 22.68444  ? 57  ARG A C   1 
ATOM   401  O O   . ARG A 1 57  ? 16.40880  -9.86657  53.17049  1.000 16.63946  ? 57  ARG A O   1 
ATOM   402  C CB  . ARG A 1 57  ? 16.07696  -9.36030  49.86513  1.000 22.89902  ? 57  ARG A CB  1 
ATOM   403  C CG  . ARG A 1 57  ? 15.41542  -10.65690 49.78072  1.000 30.14635  ? 57  ARG A CG  1 
ATOM   404  C CD  . ARG A 1 57  ? 14.60006  -10.75624 48.44799  1.000 38.34931  ? 57  ARG A CD  1 
ATOM   405  N NE  . ARG A 1 57  ? 13.53223  -9.76269  48.30886  1.000 37.56357  ? 57  ARG A NE  1 
ATOM   406  C CZ  . ARG A 1 57  ? 12.57141  -9.82836  47.39054  1.000 46.63810  ? 57  ARG A CZ  1 
ATOM   407  N NH1 . ARG A 1 57  ? 12.48655  -10.84635 46.54850  1.000 50.15691  ? 57  ARG A NH1 1 
ATOM   408  N NH2 . ARG A 1 57  ? 11.67434  -8.84723  47.30803  1.000 42.41865  ? 57  ARG A NH2 1 
ATOM   409  N N   . ALA A 1 58  ? 15.80789  -7.82021  52.44469  1.000 12.47239  ? 58  ALA A N   1 
ATOM   410  C CA  . ALA A 1 58  ? 15.00170  -7.45958  53.60503  1.000 15.25195  ? 58  ALA A CA  1 
ATOM   411  C C   . ALA A 1 58  ? 13.86285  -6.59610  53.05355  1.000 17.11548  ? 58  ALA A C   1 
ATOM   412  O O   . ALA A 1 58  ? 13.96298  -6.07721  51.93731  1.000 15.33759  ? 58  ALA A O   1 
ATOM   413  C CB  . ALA A 1 58  ? 15.83999  -6.73186  54.65899  1.000 12.65808  ? 58  ALA A CB  1 
ATOM   414  N N   . TYR A 1 59  ? 12.77459  -6.45804  53.81342  1.000 17.99725  ? 59  TYR A N   1 
ATOM   415  C CA  . TYR A 1 59  ? 11.56548  -5.84862  53.26975  1.000 16.50810  ? 59  TYR A CA  1 
ATOM   416  C C   . TYR A 1 59  ? 10.73822  -5.25246  54.39905  1.000 18.69495  ? 59  TYR A C   1 
ATOM   417  O O   . TYR A 1 59  ? 10.59412  -5.85887  55.45532  1.000 12.81045  ? 59  TYR A O   1 
ATOM   418  C CB  . TYR A 1 59  ? 10.72285  -6.91183  52.54854  1.000 12.63565  ? 59  TYR A CB  1 
ATOM   419  C CG  . TYR A 1 59  ? 9.34860   -6.52404  52.04437  1.000 17.05855  ? 59  TYR A CG  1 
ATOM   420  C CD1 . TYR A 1 59  ? 9.19545   -5.87439  50.81857  1.000 14.57190  ? 59  TYR A CD1 1 
ATOM   421  C CD2 . TYR A 1 59  ? 8.18448   -6.92060  52.73037  1.000 19.87113  ? 59  TYR A CD2 1 
ATOM   422  C CE1 . TYR A 1 59  ? 7.91127   -5.57533  50.31386  1.000 16.76625  ? 59  TYR A CE1 1 
ATOM   423  C CE2 . TYR A 1 59  ? 6.90057   -6.62476  52.22117  1.000 19.33298  ? 59  TYR A CE2 1 
ATOM   424  C CZ  . TYR A 1 59  ? 6.78293   -5.95446  51.01431  1.000 18.85392  ? 59  TYR A CZ  1 
ATOM   425  O OH  . TYR A 1 59  ? 5.54954   -5.68475  50.46573  1.000 19.12948  ? 59  TYR A OH  1 
ATOM   426  N N   . ASP A 1 60  ? 10.10186  -4.11256  54.12248  1.000 15.70872  ? 60  ASP A N   1 
ATOM   427  C CA  . ASP A 1 60  ? 9.00448   -3.65631  54.96587  1.000 15.53663  ? 60  ASP A CA  1 
ATOM   428  C C   . ASP A 1 60  ? 8.10886   -2.72730  54.14024  1.000 15.43876  ? 60  ASP A C   1 
ATOM   429  O O   . ASP A 1 60  ? 8.41151   -2.39218  52.99227  1.000 14.29760  ? 60  ASP A O   1 
ATOM   430  C CB  . ASP A 1 60  ? 9.52178   -2.97721  56.24062  1.000 13.48439  ? 60  ASP A CB  1 
ATOM   431  C CG  . ASP A 1 60  ? 9.57985   -3.94399  57.44796  1.000 23.11382  ? 60  ASP A CG  1 
ATOM   432  O OD1 . ASP A 1 60  ? 8.57942   -4.68070  57.72922  1.000 20.08364  ? 60  ASP A OD1 1 
ATOM   433  O OD2 . ASP A 1 60  ? 10.64365  -3.95113  58.11473  1.000 20.17708  ? 60  ASP A OD2 1 
ATOM   434  N N   . ARG A 1 61  ? 6.96580   -2.36561  54.73192  1.000 12.09459  ? 61  ARG A N   1 
ATOM   435  C CA  . ARG A 1 61  ? 5.97475   -1.53262  54.07456  1.000 12.38254  ? 61  ARG A CA  1 
ATOM   436  C C   . ARG A 1 61  ? 5.62813   -0.40884  55.01675  1.000 13.21403  ? 61  ARG A C   1 
ATOM   437  O O   . ARG A 1 61  ? 5.58180   -0.61578  56.24393  1.000 12.89478  ? 61  ARG A O   1 
ATOM   438  C CB  . ARG A 1 61  ? 4.65213   -2.32726  53.73953  1.000 12.15400  ? 61  ARG A CB  1 
ATOM   439  C CG  . ARG A 1 61  ? 4.91719   -3.62102  52.95683  1.000 19.22989  ? 61  ARG A CG  1 
ATOM   440  C CD  . ARG A 1 61  ? 3.55900   -4.36464  52.75674  1.000 19.37786  ? 61  ARG A CD  1 
ATOM   441  N NE  . ARG A 1 61  ? 2.72523   -3.69920  51.77295  1.000 20.67594  ? 61  ARG A NE  1 
ATOM   442  C CZ  . ARG A 1 61  ? 1.56335   -4.19348  51.35841  1.000 33.26224  ? 61  ARG A CZ  1 
ATOM   443  N NH1 . ARG A 1 61  ? 1.08431   -5.33631  51.83701  1.000 29.00429  ? 61  ARG A NH1 1 
ATOM   444  N NH2 . ARG A 1 61  ? 0.86728   -3.53148  50.44263  1.000 28.40910  ? 61  ARG A NH2 1 
ATOM   445  N N   . PHE A 1 62  ? 5.37970   0.77597   54.42753  1.000 14.89355  ? 62  PHE A N   1 
ATOM   446  C CA  . PHE A 1 62  ? 5.11401   2.01259   55.16688  1.000 12.82179  ? 62  PHE A CA  1 
ATOM   447  C C   . PHE A 1 62  ? 3.79820   2.59703   54.68435  1.000 14.60414  ? 62  PHE A C   1 
ATOM   448  O O   . PHE A 1 62  ? 3.50900   2.59991   53.47916  1.000 12.88983  ? 62  PHE A O   1 
ATOM   449  C CB  . PHE A 1 62  ? 6.23289   3.06539   54.96660  1.000 7.17720   ? 62  PHE A CB  1 
ATOM   450  C CG  . PHE A 1 62  ? 7.59283   2.58491   55.46412  1.000 13.13233  ? 62  PHE A CG  1 
ATOM   451  C CD1 . PHE A 1 62  ? 7.95921   2.74914   56.79955  1.000 13.27101  ? 62  PHE A CD1 1 
ATOM   452  C CD2 . PHE A 1 62  ? 8.45978   1.90653   54.60901  1.000 13.55277  ? 62  PHE A CD2 1 
ATOM   453  C CE1 . PHE A 1 62  ? 9.19398   2.29528   57.27905  1.000 18.11862  ? 62  PHE A CE1 1 
ATOM   454  C CE2 . PHE A 1 62  ? 9.71575   1.43331   55.08622  1.000 15.68152  ? 62  PHE A CE2 1 
ATOM   455  C CZ  . PHE A 1 62  ? 10.06599  1.61659   56.42540  1.000 14.75551  ? 62  PHE A CZ  1 
ATOM   456  N N   . PHE A 1 63  ? 3.03817   3.11378   55.63787  1.000 11.74345  ? 63  PHE A N   1 
ATOM   457  C CA  . PHE A 1 63  ? 1.91260   4.00442   55.37674  1.000 14.47862  ? 63  PHE A CA  1 
ATOM   458  C C   . PHE A 1 63  ? 2.47712   5.42194   55.26717  1.000 14.66813  ? 63  PHE A C   1 
ATOM   459  O O   . PHE A 1 63  ? 3.22145   5.85721   56.14830  1.000 17.14590  ? 63  PHE A O   1 
ATOM   460  C CB  . PHE A 1 63  ? 0.93807   3.83491   56.55237  1.000 15.80444  ? 63  PHE A CB  1 
ATOM   461  C CG  . PHE A 1 63  ? -0.21170  4.83882   56.63135  1.000 17.02066  ? 63  PHE A CG  1 
ATOM   462  C CD1 . PHE A 1 63  ? 0.01185   6.13731   57.04826  1.000 21.67509  ? 63  PHE A CD1 1 
ATOM   463  C CD2 . PHE A 1 63  ? -1.52289  4.40628   56.43296  1.000 22.08982  ? 63  PHE A CD2 1 
ATOM   464  C CE1 . PHE A 1 63  ? -1.04097  7.01335   57.18459  1.000 23.47733  ? 63  PHE A CE1 1 
ATOM   465  C CE2 . PHE A 1 63  ? -2.58565  5.28989   56.56216  1.000 20.86512  ? 63  PHE A CE2 1 
ATOM   466  C CZ  . PHE A 1 63  ? -2.32818  6.58892   56.92030  1.000 21.51132  ? 63  PHE A CZ  1 
ATOM   467  N N   . PHE A 1 64  ? 2.16217   6.13850   54.17548  1.000 12.56705  ? 64  PHE A N   1 
ATOM   468  C CA  . PHE A 1 64  ? 2.77641   7.42810   53.91848  1.000 13.57945  ? 64  PHE A CA  1 
ATOM   469  C C   . PHE A 1 64  ? 1.70318   8.40732   53.46192  1.000 15.44240  ? 64  PHE A C   1 
ATOM   470  O O   . PHE A 1 64  ? 0.93000   8.06728   52.56927  1.000 13.58311  ? 64  PHE A O   1 
ATOM   471  C CB  . PHE A 1 64  ? 3.84237   7.24871   52.83720  1.000 12.63513  ? 64  PHE A CB  1 
ATOM   472  C CG  . PHE A 1 64  ? 4.38883   8.51700   52.22082  1.000 14.38934  ? 64  PHE A CG  1 
ATOM   473  C CD1 . PHE A 1 64  ? 4.87106   9.57714   53.00508  1.000 15.44610  ? 64  PHE A CD1 1 
ATOM   474  C CD2 . PHE A 1 64  ? 4.48337   8.60426   50.84817  1.000 12.46757  ? 64  PHE A CD2 1 
ATOM   475  C CE1 . PHE A 1 64  ? 5.44739   10.72099  52.39237  1.000 16.06942  ? 64  PHE A CE1 1 
ATOM   476  C CE2 . PHE A 1 64  ? 5.02529   9.71535   50.23059  1.000 14.88418  ? 64  PHE A CE2 1 
ATOM   477  C CZ  . PHE A 1 64  ? 5.54058   10.77907  51.01572  1.000 14.61073  ? 64  PHE A CZ  1 
ATOM   478  N N   . VAL A 1 65  ? 1.63621   9.59101   54.07886  1.000 15.46388  ? 65  VAL A N   1 
ATOM   479  C CA  . VAL A 1 65  ? 0.71010   10.63558  53.64282  1.000 17.31173  ? 65  VAL A CA  1 
ATOM   480  C C   . VAL A 1 65  ? 1.54706   11.77625  53.08145  1.000 18.40163  ? 65  VAL A C   1 
ATOM   481  O O   . VAL A 1 65  ? 2.23399   12.48764  53.84136  1.000 20.05342  ? 65  VAL A O   1 
ATOM   482  C CB  . VAL A 1 65  ? -0.21107  11.14931  54.76034  1.000 20.00477  ? 65  VAL A CB  1 
ATOM   483  C CG1 . VAL A 1 65  ? -1.09320  12.28674  54.19253  1.000 22.92742  ? 65  VAL A CG1 1 
ATOM   484  C CG2 . VAL A 1 65  ? -1.12070  10.05100  55.30474  1.000 16.82623  ? 65  VAL A CG2 1 
ATOM   485  N N   . PRO A 1 66  ? 1.56614   11.97602  51.77386  1.000 15.73450  ? 66  PRO A N   1 
ATOM   486  C CA  . PRO A 1 66  ? 2.49959   12.96688  51.24046  1.000 15.98110  ? 66  PRO A CA  1 
ATOM   487  C C   . PRO A 1 66  ? 2.26141   14.37747  51.79988  1.000 21.76140  ? 66  PRO A C   1 
ATOM   488  O O   . PRO A 1 66  ? 3.23314   15.08657  52.09874  1.000 18.46655  ? 66  PRO A O   1 
ATOM   489  C CB  . PRO A 1 66  ? 2.26040   12.87595  49.72099  1.000 19.30704  ? 66  PRO A CB  1 
ATOM   490  C CG  . PRO A 1 66  ? 1.81119   11.40129  49.52669  1.000 15.83179  ? 66  PRO A CG  1 
ATOM   491  C CD  . PRO A 1 66  ? 0.87768   11.21251  50.71784  1.000 16.87088  ? 66  PRO A CD  1 
ATOM   492  N N   . ARG A 1 67  ? 0.99935   14.79235  51.95937  1.000 20.56977  ? 67  ARG A N   1 
ATOM   493  C CA  . ARG A 1 67  ? 0.71439   16.15200  52.44822  1.000 28.60985  ? 67  ARG A CA  1 
ATOM   494  C C   . ARG A 1 67  ? 1.42520   16.42565  53.76558  1.000 27.11960  ? 67  ARG A C   1 
ATOM   495  O O   . ARG A 1 67  ? 2.11433   17.44598  53.90768  1.000 30.87737  ? 67  ARG A O   1 
ATOM   496  C CB  . ARG A 1 67  ? -0.80660  16.35780  52.61490  1.000 27.34853  ? 67  ARG A CB  1 
ATOM   497  C CG  . ARG A 1 67  ? -1.27560  17.83982  52.83570  1.000 40.59563  ? 67  ARG A CG  1 
ATOM   498  C CD  . ARG A 1 67  ? -1.43241  18.60533  51.48426  1.000 35.32463  ? 67  ARG A CD  1 
ATOM   499  N NE  . ARG A 1 67  ? -2.60171  18.15094  50.72784  1.000 38.20167  ? 67  ARG A NE  1 
ATOM   500  C CZ  . ARG A 1 67  ? -2.85510  18.47075  49.45899  1.000 44.23877  ? 67  ARG A CZ  1 
ATOM   501  N NH1 . ARG A 1 67  ? -2.03081  19.23916  48.76828  1.000 36.55225  ? 67  ARG A NH1 1 
ATOM   502  N NH2 . ARG A 1 67  ? -3.96297  17.99915  48.86755  1.000 30.56748  ? 67  ARG A NH2 1 
ATOM   503  N N   . THR A 1 68  ? 1.30957   15.49582  54.73398  1.000 24.30139  ? 68  THR A N   1 
ATOM   504  C CA  . THR A 1 68  ? 1.89602   15.71939  56.05988  1.000 30.32659  ? 68  THR A CA  1 
ATOM   505  C C   . THR A 1 68  ? 3.31178   15.18371  56.21414  1.000 32.00810  ? 68  THR A C   1 
ATOM   506  O O   . THR A 1 68  ? 4.01798   15.57620  57.15469  1.000 31.78579  ? 68  THR A O   1 
ATOM   507  C CB  . THR A 1 68  ? 1.00460   15.11859  57.15258  1.000 29.69143  ? 68  THR A CB  1 
ATOM   508  O OG1 . THR A 1 68  ? 0.78523   13.70064  56.95560  1.000 24.77270  ? 68  THR A OG1 1 
ATOM   509  C CG2 . THR A 1 68  ? -0.31101  15.77775  57.11401  1.000 28.98088  ? 68  THR A CG2 1 
ATOM   510  N N   . GLY A 1 69  ? 3.76137   14.32622  55.31295  1.000 23.36670  ? 69  GLY A N   1 
ATOM   511  C CA  . GLY A 1 69  ? 5.00892   13.63710  55.54985  1.000 19.58708  ? 69  GLY A CA  1 
ATOM   512  C C   . GLY A 1 69  ? 4.93710   12.53922  56.59135  1.000 21.27708  ? 69  GLY A C   1 
ATOM   513  O O   . GLY A 1 69  ? 5.99349   11.99694  56.95485  1.000 24.11969  ? 69  GLY A O   1 
ATOM   514  N N   . GLU A 1 70  ? 3.73463   12.20672  57.08416  1.000 18.06545  ? 70  GLU A N   1 
ATOM   515  C CA  . GLU A 1 70  ? 3.56882   11.11645  58.03404  1.000 19.47134  ? 70  GLU A CA  1 
ATOM   516  C C   . GLU A 1 70  ? 4.01914   9.79488   57.39820  1.000 21.21767  ? 70  GLU A C   1 
ATOM   517  O O   . GLU A 1 70  ? 3.63001   9.46814   56.25853  1.000 15.12371  ? 70  GLU A O   1 
ATOM   518  C CB  . GLU A 1 70  ? 2.10793   11.00582  58.47604  1.000 21.54184  ? 70  GLU A CB  1 
ATOM   519  C CG  . GLU A 1 70  ? 1.88567   9.86659   59.49133  1.000 23.80352  ? 70  GLU A CG  1 
ATOM   520  C CD  . GLU A 1 70  ? 0.49350   9.76541   60.01902  1.000 23.20576  ? 70  GLU A CD  1 
ATOM   521  O OE1 . GLU A 1 70  ? -0.40768  10.28409  59.35146  1.000 30.55549  ? 70  GLU A OE1 1 
ATOM   522  O OE2 . GLU A 1 70  ? 0.31273   9.16996   61.10429  1.000 25.79835  ? 70  GLU A OE2 1 
ATOM   523  N N   . VAL A 1 71  ? 4.86584   9.06022   58.12156  1.000 16.94382  ? 71  VAL A N   1 
ATOM   524  C CA  . VAL A 1 71  ? 5.35068   7.74074   57.70422  1.000 15.70595  ? 71  VAL A CA  1 
ATOM   525  C C   . VAL A 1 71  ? 5.17554   6.80201   58.90622  1.000 16.29894  ? 71  VAL A C   1 
ATOM   526  O O   . VAL A 1 71  ? 5.61538   7.11029   60.01353  1.000 14.94520  ? 71  VAL A O   1 
ATOM   527  C CB  . VAL A 1 71  ? 6.81359   7.74844   57.23358  1.000 13.73824  ? 71  VAL A CB  1 
ATOM   528  C CG1 . VAL A 1 71  ? 7.19464   6.32016   56.57379  1.000 13.01938  ? 71  VAL A CG1 1 
ATOM   529  C CG2 . VAL A 1 71  ? 7.13749   8.90871   56.24817  1.000 15.40086  ? 71  VAL A CG2 1 
ATOM   530  N N   . ARG A 1 72  ? 4.46337   5.71302   58.71086  1.000 11.87825  ? 72  ARG A N   1 
ATOM   531  C CA  . ARG A 1 72  ? 4.26453   4.70071   59.75224  1.000 15.98782  ? 72  ARG A CA  1 
ATOM   532  C C   . ARG A 1 72  ? 4.77842   3.36017   59.22068  1.000 14.74305  ? 72  ARG A C   1 
ATOM   533  O O   . ARG A 1 72  ? 4.49537   3.00330   58.07714  1.000 12.66336  ? 72  ARG A O   1 
ATOM   534  C CB  . ARG A 1 72  ? 2.78700   4.58249   60.10549  1.000 16.19965  ? 72  ARG A CB  1 
ATOM   535  C CG  . ARG A 1 72  ? 2.08233   5.97738   60.38862  1.000 20.54706  ? 72  ARG A CG  1 
ATOM   536  C CD  . ARG A 1 72  ? 0.60245   5.77921   60.60933  1.000 22.39608  ? 72  ARG A CD  1 
ATOM   537  N NE  . ARG A 1 72  ? 0.30612   4.84823   61.70136  1.000 21.15009  ? 72  ARG A NE  1 
ATOM   538  C CZ  . ARG A 1 72  ? 0.45232   5.14669   62.97756  1.000 23.62488  ? 72  ARG A CZ  1 
ATOM   539  N NH1 . ARG A 1 72  ? 0.91725   6.33011   63.35754  1.000 22.34618  ? 72  ARG A NH1 1 
ATOM   540  N NH2 . ARG A 1 72  ? 0.16560   4.22511   63.89903  1.000 21.33463  ? 72  ARG A NH2 1 
ATOM   541  N N   . LEU A 1 73  ? 5.52308   2.62269   60.03104  1.000 15.76078  ? 73  LEU A N   1 
ATOM   542  C CA  . LEU A 1 73  ? 5.90637   1.26715   59.64652  1.000 12.25597  ? 73  LEU A CA  1 
ATOM   543  C C   . LEU A 1 73  ? 4.72420   0.31962   59.80994  1.000 12.63502  ? 73  LEU A C   1 
ATOM   544  O O   . LEU A 1 73  ? 4.21459   0.14690   60.92014  1.000 14.58650  ? 73  LEU A O   1 
ATOM   545  C CB  . LEU A 1 73  ? 7.09156   0.80942   60.51241  1.000 15.84492  ? 73  LEU A CB  1 
ATOM   546  C CG  . LEU A 1 73  ? 7.53064   -0.66102  60.38395  1.000 12.92687  ? 73  LEU A CG  1 
ATOM   547  C CD1 . LEU A 1 73  ? 8.12218   -0.88857  58.97829  1.000 11.50067  ? 73  LEU A CD1 1 
ATOM   548  C CD2 . LEU A 1 73  ? 8.60381   -0.94387  61.48063  1.000 15.77106  ? 73  LEU A CD2 1 
ATOM   549  N N   . ARG A 1 74  ? 4.30232   -0.33022  58.72354  1.000 11.58341  ? 74  ARG A N   1 
ATOM   550  C CA  . ARG A 1 74  ? 3.17834   -1.25185  58.83726  1.000 11.69729  ? 74  ARG A CA  1 
ATOM   551  C C   . ARG A 1 74  ? 3.61093   -2.55771  59.52651  1.000 14.25071  ? 74  ARG A C   1 
ATOM   552  O O   . ARG A 1 74  ? 4.76040   -2.99307  59.39996  1.000 14.83769  ? 74  ARG A O   1 
ATOM   553  C CB  . ARG A 1 74  ? 2.56234   -1.55032  57.46147  1.000 14.41240  ? 74  ARG A CB  1 
ATOM   554  C CG  . ARG A 1 74  ? 2.08104   -0.23239  56.73249  1.000 16.42303  ? 74  ARG A CG  1 
ATOM   555  C CD  . ARG A 1 74  ? 1.45056   -0.56109  55.41522  1.000 19.62647  ? 74  ARG A CD  1 
ATOM   556  N NE  . ARG A 1 74  ? 0.29296   -1.44449  55.56274  1.000 19.77819  ? 74  ARG A NE  1 
ATOM   557  C CZ  . ARG A 1 74  ? -0.34469  -1.97721  54.53100  1.000 27.22715  ? 74  ARG A CZ  1 
ATOM   558  N NH1 . ARG A 1 74  ? 0.05270   -1.75596  53.27810  1.000 22.68026  ? 74  ARG A NH1 1 
ATOM   559  N NH2 . ARG A 1 74  ? -1.40799  -2.74123  54.75190  1.000 29.70107  ? 74  ARG A NH2 1 
ATOM   560  N N   . PRO A 1 75  ? 2.71447   -3.15973  60.31276  1.000 18.28114  ? 75  PRO A N   1 
ATOM   561  C CA  . PRO A 1 75  ? 3.02985   -4.43793  60.97635  1.000 18.62411  ? 75  PRO A CA  1 
ATOM   562  C C   . PRO A 1 75  ? 3.44532   -5.48875  59.97502  1.000 15.30617  ? 75  PRO A C   1 
ATOM   563  O O   . PRO A 1 75  ? 2.90515   -5.55876  58.86998  1.000 13.53588  ? 75  PRO A O   1 
ATOM   564  C CB  . PRO A 1 75  ? 1.71232   -4.84578  61.66013  1.000 24.31523  ? 75  PRO A CB  1 
ATOM   565  C CG  . PRO A 1 75  ? 0.77340   -3.69356  61.53288  1.000 24.72593  ? 75  PRO A CG  1 
ATOM   566  C CD  . PRO A 1 75  ? 1.36201   -2.64593  60.61474  1.000 18.67925  ? 75  PRO A CD  1 
ATOM   567  N N   . HIS A 1 76  ? 4.42663   -6.29682  60.38422  1.000 18.83380  ? 76  HIS A N   1 
ATOM   568  C CA  . HIS A 1 76  ? 4.93582   -7.38753  59.56531  1.000 21.72299  ? 76  HIS A CA  1 
ATOM   569  C C   . HIS A 1 76  ? 3.82940   -8.43073  59.34107  1.000 21.87671  ? 76  HIS A C   1 
ATOM   570  O O   . HIS A 1 76  ? 3.12543   -8.83201  60.28747  1.000 19.70150  ? 76  HIS A O   1 
ATOM   571  C CB  . HIS A 1 76  ? 6.15977   -8.00126  60.26548  1.000 25.30735  ? 76  HIS A CB  1 
ATOM   572  C CG  . HIS A 1 76  ? 6.48673   -9.40595  59.83404  1.000 24.93698  ? 76  HIS A CG  1 
ATOM   573  N ND1 . HIS A 1 76  ? 7.27025   -9.68889  58.73846  1.000 25.67469  ? 76  HIS A ND1 1 
ATOM   574  C CD2 . HIS A 1 76  ? 6.14553   -10.60703 60.37732  1.000 19.83270  ? 76  HIS A CD2 1 
ATOM   575  C CE1 . HIS A 1 76  ? 7.38480   -11.00402 58.61542  1.000 24.28664  ? 76  HIS A CE1 1 
ATOM   576  N NE2 . HIS A 1 76  ? 6.71832   -11.58257 59.60688  1.000 20.68751  ? 76  HIS A NE2 1 
ATOM   577  N N   . ARG A 1 77  ? 3.61802   -8.81562  58.08475  1.000 17.59008  ? 77  ARG A N   1 
ATOM   578  C CA  . ARG A 1 77  ? 2.57170   -9.79627  57.78144  1.000 16.09210  ? 77  ARG A CA  1 
ATOM   579  C C   . ARG A 1 77  ? 3.24287   -11.14685 57.56617  1.000 17.51612  ? 77  ARG A C   1 
ATOM   580  O O   . ARG A 1 77  ? 3.99260   -11.29025 56.60171  1.000 14.31184  ? 77  ARG A O   1 
ATOM   581  C CB  . ARG A 1 77  ? 1.76867   -9.38950  56.53579  1.000 26.74040  ? 77  ARG A CB  1 
ATOM   582  C CG  . ARG A 1 77  ? 0.64682   -10.38727 56.16710  1.000 22.78187  ? 77  ARG A CG  1 
ATOM   583  C CD  . ARG A 1 77  ? -0.08470  -9.99739  54.86972  1.000 28.00505  ? 77  ARG A CD  1 
ATOM   584  N NE  . ARG A 1 77  ? -1.10317  -10.98546 54.49836  1.000 23.79600  ? 77  ARG A NE  1 
ATOM   585  C CZ  . ARG A 1 77  ? -2.36379  -10.93665 54.90281  1.000 32.13892  ? 77  ARG A CZ  1 
ATOM   586  N NH1 . ARG A 1 77  ? -2.80262  -9.94842  55.67934  1.000 31.00392  ? 77  ARG A NH1 1 
ATOM   587  N NH2 . ARG A 1 77  ? -3.20214  -11.90447 54.52870  1.000 27.89151  ? 77  ARG A NH2 1 
ATOM   588  N N   . PRO A 1 78  ? 3.05337   -12.13663 58.45319  1.000 17.88437  ? 78  PRO A N   1 
ATOM   589  C CA  . PRO A 1 78  ? 3.83280   -13.37740 58.34749  1.000 19.54174  ? 78  PRO A CA  1 
ATOM   590  C C   . PRO A 1 78  ? 3.57480   -14.11319 57.03620  1.000 17.09599  ? 78  PRO A C   1 
ATOM   591  O O   . PRO A 1 78  ? 2.44551   -14.19976 56.55305  1.000 14.14801  ? 78  PRO A O   1 
ATOM   592  C CB  . PRO A 1 78  ? 3.37028   -14.19536 59.56464  1.000 15.78706  ? 78  PRO A CB  1 
ATOM   593  C CG  . PRO A 1 78  ? 2.91940   -13.13682 60.58755  1.000 16.28774  ? 78  PRO A CG  1 
ATOM   594  C CD  . PRO A 1 78  ? 2.24599   -12.09236 59.69548  1.000 15.68727  ? 78  PRO A CD  1 
ATOM   595  N N   . TYR A 1 79  ? 4.65714   -14.61051 56.45512  1.000 15.49756  ? 79  TYR A N   1 
ATOM   596  C CA  . TYR A 1 79  ? 4.55168   -15.37424 55.22098  1.000 21.34062  ? 79  TYR A CA  1 
ATOM   597  C C   . TYR A 1 79  ? 3.59497   -16.54704 55.36695  1.000 20.26765  ? 79  TYR A C   1 
ATOM   598  O O   . TYR A 1 79  ? 2.77285   -16.80339 54.47505  1.000 19.72387  ? 79  TYR A O   1 
ATOM   599  C CB  . TYR A 1 79  ? 5.94394   -15.83153 54.80949  1.000 20.34584  ? 79  TYR A CB  1 
ATOM   600  C CG  . TYR A 1 79  ? 5.96650   -16.61065 53.52636  1.000 24.23118  ? 79  TYR A CG  1 
ATOM   601  C CD1 . TYR A 1 79  ? 5.69424   -16.00699 52.30884  1.000 27.79372  ? 79  TYR A CD1 1 
ATOM   602  C CD2 . TYR A 1 79  ? 6.28251   -17.96576 53.54207  1.000 28.23309  ? 79  TYR A CD2 1 
ATOM   603  C CE1 . TYR A 1 79  ? 5.69478   -16.76799 51.09896  1.000 30.95638  ? 79  TYR A CE1 1 
ATOM   604  C CE2 . TYR A 1 79  ? 6.33071   -18.70095 52.38450  1.000 35.52006  ? 79  TYR A CE2 1 
ATOM   605  C CZ  . TYR A 1 79  ? 6.03018   -18.11052 51.16736  1.000 32.04355  ? 79  TYR A CZ  1 
ATOM   606  O OH  . TYR A 1 79  ? 6.07580   -18.91126 50.06155  1.000 40.77974  ? 79  TYR A OH  1 
ATOM   607  N N   . PHE A 1 80  ? 3.64847   -17.25001 56.50924  1.000 20.89211  ? 80  PHE A N   1 
ATOM   608  C CA  . PHE A 1 80  ? 2.76271   -18.39765 56.67940  1.000 20.63268  ? 80  PHE A CA  1 
ATOM   609  C C   . PHE A 1 80  ? 1.32110   -17.96275 56.67226  1.000 21.23677  ? 80  PHE A C   1 
ATOM   610  O O   . PHE A 1 80  ? 0.45227   -18.72221 56.24738  1.000 22.05325  ? 80  PHE A O   1 
ATOM   611  C CB  . PHE A 1 80  ? 3.07946   -19.18586 57.96939  1.000 17.99935  ? 80  PHE A CB  1 
ATOM   612  C CG  . PHE A 1 80  ? 2.69003   -18.46419 59.24745  1.000 16.14273  ? 80  PHE A CG  1 
ATOM   613  C CD1 . PHE A 1 80  ? 1.39171   -18.52388 59.72585  1.000 16.17667  ? 80  PHE A CD1 1 
ATOM   614  C CD2 . PHE A 1 80  ? 3.62943   -17.74182 59.97088  1.000 15.24108  ? 80  PHE A CD2 1 
ATOM   615  C CE1 . PHE A 1 80  ? 1.03530   -17.86369 60.89383  1.000 19.31744  ? 80  PHE A CE1 1 
ATOM   616  C CE2 . PHE A 1 80  ? 3.28193   -17.07552 61.14016  1.000 14.95013  ? 80  PHE A CE2 1 
ATOM   617  C CZ  . PHE A 1 80  ? 1.97224   -17.10676 61.57639  1.000 15.37725  ? 80  PHE A CZ  1 
ATOM   618  N N   . GLN A 1 81  ? 1.03349   -16.75625 57.15760  1.000 17.62047  ? 81  GLN A N   1 
ATOM   619  C CA  . GLN A 1 81  ? -0.34203  -16.30308 57.16626  1.000 16.06323  ? 81  GLN A CA  1 
ATOM   620  C C   . GLN A 1 81  ? -0.81499  -16.03429 55.73987  1.000 22.19070  ? 81  GLN A C   1 
ATOM   621  O O   . GLN A 1 81  ? -1.86108  -16.53260 55.31318  1.000 20.64948  ? 81  GLN A O   1 
ATOM   622  C CB  . GLN A 1 81  ? -0.48716  -15.04295 58.04069  1.000 17.57311  ? 81  GLN A CB  1 
ATOM   623  C CG  . GLN A 1 81  ? -1.91494  -14.60764 58.16200  1.000 18.02988  ? 81  GLN A CG  1 
ATOM   624  C CD  . GLN A 1 81  ? -2.02217  -13.19976 58.73843  1.000 24.90699  ? 81  GLN A CD  1 
ATOM   625  O OE1 . GLN A 1 81  ? -1.21990  -12.80387 59.60137  1.000 24.55330  ? 81  GLN A OE1 1 
ATOM   626  N NE2 . GLN A 1 81  ? -2.98835  -12.44404 58.26169  1.000 28.83506  ? 81  GLN A NE2 1 
ATOM   627  N N   . SER A 1 82  ? -0.04889  -15.25090 54.98385  1.000 21.49551  ? 82  SER A N   1 
ATOM   628  C CA  . SER A 1 82  ? -0.41199  -14.96798 53.59244  1.000 18.97576  ? 82  SER A CA  1 
ATOM   629  C C   . SER A 1 82  ? -0.51960  -16.24839 52.78203  1.000 21.17738  ? 82  SER A C   1 
ATOM   630  O O   . SER A 1 82  ? -1.45747  -16.42043 51.99215  1.000 21.36561  ? 82  SER A O   1 
ATOM   631  C CB  . SER A 1 82  ? 0.63919   -14.05018 52.95111  1.000 19.96732  ? 82  SER A CB  1 
ATOM   632  O OG  . SER A 1 82  ? 0.71169   -12.81456 53.65535  1.000 24.32555  ? 82  SER A OG  1 
ATOM   633  N N   . MET A 1 83  ? 0.47289   -17.12405 52.91778  1.000 20.95463  ? 83  MET A N   1 
ATOM   634  C CA  . MET A 1 83  ? 0.47355   -18.37155 52.15355  1.000 25.49016  ? 83  MET A CA  1 
ATOM   635  C C   . MET A 1 83  ? -0.76179  -19.21048 52.48296  1.000 27.34172  ? 83  MET A C   1 
ATOM   636  O O   . MET A 1 83  ? -1.46888  -19.66716 51.58382  1.000 25.51467  ? 83  MET A O   1 
ATOM   637  C CB  . MET A 1 83  ? 1.76489   -19.15565 52.43211  1.000 24.27991  ? 83  MET A CB  1 
ATOM   638  C CG  . MET A 1 83  ? 1.56434   -20.67883 52.35894  1.000 61.71601  ? 83  MET A CG  1 
ATOM   639  S SD  . MET A 1 83  ? 3.07811   -21.62513 52.10938  1.000 62.78591  ? 83  MET A SD  1 
ATOM   640  C CE  . MET A 1 83  ? 3.62053   -20.85448 50.60736  1.000 40.21996  ? 83  MET A CE  1 
ATOM   641  N N   . ASN A 1 84  ? -1.09532  -19.34751 53.77345  1.000 22.38708  ? 84  ASN A N   1 
ATOM   642  C CA  . ASN A 1 84  ? -2.26506  -20.16180 54.10770  1.000 23.95070  ? 84  ASN A CA  1 
ATOM   643  C C   . ASN A 1 84  ? -3.57502  -19.45840 53.76924  1.000 25.51394  ? 84  ASN A C   1 
ATOM   644  O O   . ASN A 1 84  ? -4.57469  -20.13451 53.50967  1.000 23.10492  ? 84  ASN A O   1 
ATOM   645  C CB  . ASN A 1 84  ? -2.22159  -20.56901 55.58530  1.000 20.04585  ? 84  ASN A CB  1 
ATOM   646  C CG  . ASN A 1 84  ? -1.28314  -21.72952 55.80721  1.000 26.94746  ? 84  ASN A CG  1 
ATOM   647  O OD1 . ASN A 1 84  ? -1.61692  -22.87634 55.49832  1.000 25.17161  ? 84  ASN A OD1 1 
ATOM   648  N ND2 . ASN A 1 84  ? -0.06759  -21.43156 56.22945  1.000 20.56589  ? 84  ASN A ND2 1 
ATOM   649  N N   . ALA A 1 85  ? -3.59924  -18.11386 53.75764  1.000 19.73162  ? 85  ALA A N   1 
ATOM   650  C CA  . ALA A 1 85  ? -4.79768  -17.38427 53.35387  1.000 22.52693  ? 85  ALA A CA  1 
ATOM   651  C C   . ALA A 1 85  ? -4.90665  -17.21534 51.85154  1.000 25.03119  ? 85  ALA A C   1 
ATOM   652  O O   . ALA A 1 85  ? -5.92133  -16.69349 51.38214  1.000 24.69404  ? 85  ALA A O   1 
ATOM   653  C CB  . ALA A 1 85  ? -4.80593  -15.97730 53.95424  1.000 25.20085  ? 85  ALA A CB  1 
ATOM   654  N N   . ASN A 1 86  ? -3.87968  -17.60318 51.10509  1.000 25.41280  ? 86  ASN A N   1 
ATOM   655  C CA  . ASN A 1 86  ? -3.74493  -17.25091 49.69142  1.000 28.23845  ? 86  ASN A CA  1 
ATOM   656  C C   . ASN A 1 86  ? -4.07759  -15.77819 49.48110  1.000 31.06953  ? 86  ASN A C   1 
ATOM   657  O O   . ASN A 1 86  ? -4.96303  -15.40651 48.70363  1.000 29.26160  ? 86  ASN A O   1 
ATOM   658  C CB  . ASN A 1 86  ? -4.60726  -18.14713 48.79883  1.000 36.28100  ? 86  ASN A CB  1 
ATOM   659  C CG  . ASN A 1 86  ? -4.28603  -17.96755 47.30701  1.000 45.42943  ? 86  ASN A CG  1 
ATOM   660  O OD1 . ASN A 1 86  ? -3.15084  -17.65634 46.92833  1.000 46.50734  ? 86  ASN A OD1 1 
ATOM   661  N ND2 . ASN A 1 86  ? -5.28806  -18.16222 46.46287  1.000 52.18769  ? 86  ASN A ND2 1 
ATOM   662  N N   . ASP A 1 87  ? -3.37201  -14.93036 50.23398  1.000 31.07178  ? 87  ASP A N   1 
ATOM   663  C CA  . ASP A 1 87  ? -3.66252  -13.49894 50.23060  1.000 29.95920  ? 87  ASP A CA  1 
ATOM   664  C C   . ASP A 1 87  ? -2.43481  -12.76697 50.78163  1.000 30.72833  ? 87  ASP A C   1 
ATOM   665  O O   . ASP A 1 87  ? -2.21987  -12.74132 52.00027  1.000 27.01329  ? 87  ASP A O   1 
ATOM   666  C CB  . ASP A 1 87  ? -4.90183  -13.20982 51.05580  1.000 23.75918  ? 87  ASP A CB  1 
ATOM   667  C CG  . ASP A 1 87  ? -5.24115  -11.74101 51.09265  1.000 39.85212  ? 87  ASP A CG  1 
ATOM   668  O OD1 . ASP A 1 87  ? -4.49407  -10.92145 50.47187  1.000 31.79798  ? 87  ASP A OD1 1 
ATOM   669  O OD2 . ASP A 1 87  ? -6.25066  -11.41183 51.76986  1.000 42.07827  ? 87  ASP A OD2 1 
ATOM   670  N N   . TYR A 1 88  ? -1.65889  -12.16571 49.88322  1.000 29.66620  ? 88  TYR A N   1 
ATOM   671  C CA  . TYR A 1 88  ? -0.47825  -11.40809 50.25473  1.000 25.89765  ? 88  TYR A CA  1 
ATOM   672  C C   . TYR A 1 88  ? -0.79178  -9.94326  50.54055  1.000 27.64859  ? 88  TYR A C   1 
ATOM   673  O O   . TYR A 1 88  ? 0.12597   -9.15820  50.83616  1.000 27.22132  ? 88  TYR A O   1 
ATOM   674  C CB  . TYR A 1 88  ? 0.58722   -11.58198 49.16723  1.000 26.79535  ? 88  TYR A CB  1 
ATOM   675  C CG  . TYR A 1 88  ? 1.02212   -13.02805 49.12734  1.000 30.59812  ? 88  TYR A CG  1 
ATOM   676  C CD1 . TYR A 1 88  ? 0.31298   -13.96208 48.37827  1.000 33.60064  ? 88  TYR A CD1 1 
ATOM   677  C CD2 . TYR A 1 88  ? 2.07495   -13.47488 49.91042  1.000 28.69382  ? 88  TYR A CD2 1 
ATOM   678  C CE1 . TYR A 1 88  ? 0.67909   -15.30716 48.35383  1.000 34.67274  ? 88  TYR A CE1 1 
ATOM   679  C CE2 . TYR A 1 88  ? 2.45822   -14.82705 49.89738  1.000 27.85123  ? 88  TYR A CE2 1 
ATOM   680  C CZ  . TYR A 1 88  ? 1.74678   -15.72806 49.10951  1.000 38.64222  ? 88  TYR A CZ  1 
ATOM   681  O OH  . TYR A 1 88  ? 2.09670   -17.05948 49.08389  1.000 43.30784  ? 88  TYR A OH  1 
ATOM   682  N N   . ALA A 1 89  ? -2.06812  -9.57723  50.53078  1.000 24.83674  ? 89  ALA A N   1 
ATOM   683  C CA  . ALA A 1 89  ? -2.49952  -8.22882  50.94201  1.000 26.42003  ? 89  ALA A CA  1 
ATOM   684  C C   . ALA A 1 89  ? -1.76037  -7.15307  50.14676  1.000 27.00819  ? 89  ALA A C   1 
ATOM   685  O O   . ALA A 1 89  ? -1.46254  -6.07036  50.65836  1.000 24.67624  ? 89  ALA A O   1 
ATOM   686  C CB  . ALA A 1 89  ? -2.31315  -8.01809  52.44994  1.000 25.67009  ? 89  ALA A CB  1 
ATOM   687  N N   . GLY A 1 90  ? -1.47675  -7.45526  48.87914  1.000 20.17360  ? 90  GLY A N   1 
ATOM   688  C CA  . GLY A 1 90  ? -0.84668  -6.51458  47.99006  1.000 28.44308  ? 90  GLY A CA  1 
ATOM   689  C C   . GLY A 1 90  ? 0.64980   -6.35611  48.19007  1.000 34.73258  ? 90  GLY A C   1 
ATOM   690  O O   . GLY A 1 90  ? 1.28044   -5.59726  47.42784  1.000 28.26101  ? 90  GLY A O   1 
ATOM   691  N N   . GLY A 1 91  ? 1.24374   -7.05796  49.16509  1.000 26.17184  ? 91  GLY A N   1 
ATOM   692  C CA  . GLY A 1 91  ? 2.68398   -7.05748  49.35939  1.000 26.62953  ? 91  GLY A CA  1 
ATOM   693  C C   . GLY A 1 91  ? 3.39012   -8.14751  48.56223  1.000 26.87574  ? 91  GLY A C   1 
ATOM   694  O O   . GLY A 1 91  ? 2.81812   -8.78609  47.67931  1.000 30.40538  ? 91  GLY A O   1 
ATOM   695  N N   . ILE A 1 92  ? 4.66873   -8.37832  48.89174  1.000 23.41856  ? 92  ILE A N   1 
ATOM   696  C CA  . ILE A 1 92  ? 5.38563   -9.39018  48.10616  1.000 33.27203  ? 92  ILE A CA  1 
ATOM   697  C C   . ILE A 1 92  ? 4.90562   -10.79090 48.48706  1.000 29.23300  ? 92  ILE A C   1 
ATOM   698  O O   . ILE A 1 92  ? 4.40176   -11.04227 49.58447  1.000 24.19771  ? 92  ILE A O   1 
ATOM   699  C CB  . ILE A 1 92  ? 6.90884   -9.28635  48.26336  1.000 27.65218  ? 92  ILE A CB  1 
ATOM   700  C CG1 . ILE A 1 92  ? 7.30307   -9.58111  49.69724  1.000 25.91263  ? 92  ILE A CG1 1 
ATOM   701  C CG2 . ILE A 1 92  ? 7.37290   -7.92666  47.79750  1.000 32.18108  ? 92  ILE A CG2 1 
ATOM   702  C CD1 . ILE A 1 92  ? 8.81692   -9.58036  49.87489  1.000 34.43363  ? 92  ILE A CD1 1 
ATOM   703  N N   . ASP A 1 93  ? 5.07160   -11.71889 47.55605  1.000 27.06423  ? 93  ASP A N   1 
ATOM   704  C CA  . ASP A 1 93  ? 4.65728   -13.10125 47.76360  1.000 29.42764  ? 93  ASP A CA  1 
ATOM   705  C C   . ASP A 1 93  ? 5.86145   -14.00614 48.01361  1.000 34.00087  ? 93  ASP A C   1 
ATOM   706  O O   . ASP A 1 93  ? 5.83371   -15.20021 47.71858  1.000 33.94741  ? 93  ASP A O   1 
ATOM   707  C CB  . ASP A 1 93  ? 3.80906   -13.59685 46.59110  1.000 31.31113  ? 93  ASP A CB  1 
ATOM   708  C CG  . ASP A 1 93  ? 4.54909   -13.55328 45.27355  1.000 43.74084  ? 93  ASP A CG  1 
ATOM   709  O OD1 . ASP A 1 93  ? 5.68521   -13.05399 45.23988  1.000 38.14988  ? 93  ASP A OD1 1 
ATOM   710  O OD2 . ASP A 1 93  ? 3.99704   -14.04023 44.26891  1.000 50.85528  ? 93  ASP A OD2 1 
ATOM   711  N N   . ARG A 1 94  ? 6.91549   -13.44663 48.58518  1.000 30.70435  ? 94  ARG A N   1 
ATOM   712  C CA  . ARG A 1 94  ? 8.10632   -14.18103 48.95763  1.000 30.76195  ? 94  ARG A CA  1 
ATOM   713  C C   . ARG A 1 94  ? 8.35862   -14.01641 50.44762  1.000 31.46357  ? 94  ARG A C   1 
ATOM   714  O O   . ARG A 1 94  ? 7.90894   -13.05896 51.08178  1.000 25.37802  ? 94  ARG A O   1 
ATOM   715  C CB  . ARG A 1 94  ? 9.32408   -13.71465 48.17657  1.000 31.74338  ? 94  ARG A CB  1 
ATOM   716  C CG  . ARG A 1 94  ? 9.59389   -14.60093 46.95721  1.000 54.75196  ? 94  ARG A CG  1 
ATOM   717  C CD  . ARG A 1 94  ? 10.25531  -13.87632 45.79787  1.000 63.89362  ? 94  ARG A CD  1 
ATOM   718  N NE  . ARG A 1 94  ? 9.34328   -13.75745 44.66140  1.000 79.07018  ? 94  ARG A NE  1 
ATOM   719  C CZ  . ARG A 1 94  ? 9.58141   -13.04483 43.56582  1.000 80.63006  ? 94  ARG A CZ  1 
ATOM   720  N NH1 . ARG A 1 94  ? 10.72358  -12.39201 43.39429  1.000 87.19694  ? 94  ARG A NH1 1 
ATOM   721  N NH2 . ARG A 1 94  ? 8.64997   -12.98460 42.61892  1.000 73.31684  ? 94  ARG A NH2 1 
ATOM   722  N N   . ASP A 1 95  ? 9.10100   -14.97236 50.98097  1.000 25.13426  ? 95  ASP A N   1 
ATOM   723  C CA  . ASP A 1 95  ? 9.41164   -15.05762 52.39659  1.000 27.27158  ? 95  ASP A CA  1 
ATOM   724  C C   . ASP A 1 95  ? 10.66736  -14.23149 52.63795  1.000 28.94603  ? 95  ASP A C   1 
ATOM   725  O O   . ASP A 1 95  ? 11.75336  -14.61835 52.20642  1.000 23.70820  ? 95  ASP A O   1 
ATOM   726  C CB  . ASP A 1 95  ? 9.63337   -16.51766 52.77721  1.000 25.69782  ? 95  ASP A CB  1 
ATOM   727  C CG  . ASP A 1 95  ? 9.97805   -16.68163 54.23450  1.000 27.30038  ? 95  ASP A CG  1 
ATOM   728  O OD1 . ASP A 1 95  ? 9.74320   -15.74428 55.00121  1.000 36.07288  ? 95  ASP A OD1 1 
ATOM   729  O OD2 . ASP A 1 95  ? 10.50303  -17.72855 54.62208  1.000 30.88721  ? 95  ASP A OD2 1 
ATOM   730  N N   . VAL A 1 96  ? 10.53404  -13.09138 53.30252  1.000 22.20242  ? 96  VAL A N   1 
ATOM   731  C CA  . VAL A 1 96  ? 11.64019  -12.13460 53.40490  1.000 24.04883  ? 96  VAL A CA  1 
ATOM   732  C C   . VAL A 1 96  ? 11.69245  -11.58020 54.82860  1.000 23.87307  ? 96  VAL A C   1 
ATOM   733  O O   . VAL A 1 96  ? 10.65344  -11.32214 55.43444  1.000 24.97298  ? 96  VAL A O   1 
ATOM   734  C CB  . VAL A 1 96  ? 11.48043  -11.00400 52.35689  1.000 20.69347  ? 96  VAL A CB  1 
ATOM   735  C CG1 . VAL A 1 96  ? 12.58701  -9.95792  52.52508  1.000 21.13030  ? 96  VAL A CG1 1 
ATOM   736  C CG2 . VAL A 1 96  ? 11.56457  -11.57230 50.95474  1.000 26.54991  ? 96  VAL A CG2 1 
ATOM   737  N N   . ALA A 1 97  ? 12.88994  -11.38050 55.34860  1.000 18.93772  ? 97  ALA A N   1 
ATOM   738  C CA  . ALA A 1 97  ? 13.06479  -10.82989 56.68827  1.000 21.07894  ? 97  ALA A CA  1 
ATOM   739  C C   . ALA A 1 97  ? 12.78341  -9.31330  56.72779  1.000 18.73971  ? 97  ALA A C   1 
ATOM   740  O O   . ALA A 1 97  ? 13.00295  -8.61432  55.73207  1.000 14.84276  ? 97  ALA A O   1 
ATOM   741  C CB  . ALA A 1 97  ? 14.49201  -11.08415 57.15018  1.000 23.47495  ? 97  ALA A CB  1 
ATOM   742  N N   . PRO A 1 98  ? 12.33144  -8.78172  57.87386  1.000 19.57314  ? 98  PRO A N   1 
ATOM   743  C CA  . PRO A 1 98  ? 12.09590  -7.32130  57.98740  1.000 16.44233  ? 98  PRO A CA  1 
ATOM   744  C C   . PRO A 1 98  ? 13.39310  -6.53190  57.98574  1.000 20.32317  ? 98  PRO A C   1 
ATOM   745  O O   . PRO A 1 98  ? 14.47742  -7.04475  58.30046  1.000 13.39375  ? 98  PRO A O   1 
ATOM   746  C CB  . PRO A 1 98  ? 11.39311  -7.15064  59.34532  1.000 23.93640  ? 98  PRO A CB  1 
ATOM   747  C CG  . PRO A 1 98  ? 11.08307  -8.58425  59.85002  1.000 26.10902  ? 98  PRO A CG  1 
ATOM   748  C CD  . PRO A 1 98  ? 11.91780  -9.54860  59.08075  1.000 20.54067  ? 98  PRO A CD  1 
ATOM   749  N N   . LEU A 1 99  ? 13.26330  -5.22912  57.69563  1.000 12.97220  ? 99  LEU A N   1 
ATOM   750  C CA  . LEU A 1 99  ? 14.40816  -4.31155  57.82843  1.000 17.18786  ? 99  LEU A CA  1 
ATOM   751  C C   . LEU A 1 99  ? 15.01299  -4.31142  59.24655  1.000 15.69100  ? 99  LEU A C   1 
ATOM   752  O O   . LEU A 1 99  ? 14.31507  -4.41379  60.25207  1.000 16.24249  ? 99  LEU A O   1 
ATOM   753  C CB  . LEU A 1 99  ? 13.97448  -2.86975  57.49641  1.000 15.65338  ? 99  LEU A CB  1 
ATOM   754  C CG  . LEU A 1 99  ? 13.26361  -2.67755  56.16484  1.000 13.21726  ? 99  LEU A CG  1 
ATOM   755  C CD1 . LEU A 1 99  ? 12.85748  -1.18763  55.99664  1.000 15.28631  ? 99  LEU A CD1 1 
ATOM   756  C CD2 . LEU A 1 99  ? 14.22062  -3.15571  55.07421  1.000 13.73356  ? 99  LEU A CD2 1 
ATOM   757  N N   . SER A 1 100 ? 16.30049  -4.04323  59.33210  1.000 14.15331  ? 100 SER A N   1 
ATOM   758  C CA  . SER A 1 100 ? 16.91460  -4.07759  60.65323  1.000 16.69141  ? 100 SER A CA  1 
ATOM   759  C C   . SER A 1 100 ? 16.53437  -2.83796  61.47007  1.000 22.12821  ? 100 SER A C   1 
ATOM   760  O O   . SER A 1 100 ? 16.16491  -1.77252  60.93508  1.000 16.66330  ? 100 SER A O   1 
ATOM   761  C CB  . SER A 1 100 ? 18.42577  -4.15738  60.53195  1.000 18.27321  ? 100 SER A CB  1 
ATOM   762  O OG  . SER A 1 100 ? 18.97591  -2.91813  60.05098  1.000 19.73620  ? 100 SER A OG  1 
ATOM   763  N N   . ARG A 1 101 ? 16.68301  -2.97450  62.78901  1.000 17.15388  ? 101 ARG A N   1 
ATOM   764  C CA  . ARG A 1 101 ? 16.60311  -1.82604  63.69897  1.000 24.81524  ? 101 ARG A CA  1 
ATOM   765  C C   . ARG A 1 101 ? 17.46426  -0.64858  63.23599  1.000 19.84762  ? 101 ARG A C   1 
ATOM   766  O O   . ARG A 1 101 ? 16.99968  0.50087   63.19686  1.000 17.50127  ? 101 ARG A O   1 
ATOM   767  C CB  . ARG A 1 101 ? 17.00044  -2.26074  65.11960  1.000 25.24768  ? 101 ARG A CB  1 
ATOM   768  C CG  . ARG A 1 101 ? 17.36052  -1.10474  66.05082  1.000 30.89241  ? 101 ARG A CG  1 
ATOM   769  C CD  . ARG A 1 101 ? 17.41642  -1.55702  67.57176  1.000 34.40944  ? 101 ARG A CD  1 
ATOM   770  N NE  . ARG A 1 101 ? 16.34668  -0.92459  68.33587  1.000 34.69258  ? 101 ARG A NE  1 
ATOM   771  C CZ  . ARG A 1 101 ? 16.36179  -0.72414  69.64275  1.000 40.14296  ? 101 ARG A CZ  1 
ATOM   772  N NH1 . ARG A 1 101 ? 17.34902  -1.17420  70.40465  1.000 41.55831  ? 101 ARG A NH1 1 
ATOM   773  N NH2 . ARG A 1 101 ? 15.36454  -0.04556  70.20172  1.000 48.59601  ? 101 ARG A NH2 1 
ATOM   774  N N   . THR A 1 102 ? 18.72681  -0.89312  62.89524  1.000 16.19695  ? 102 THR A N   1 
ATOM   775  C CA  . THR A 1 102 ? 19.54878  0.25659   62.54892  1.000 18.77657  ? 102 THR A CA  1 
ATOM   776  C C   . THR A 1 102 ? 19.20339  0.83910   61.15520  1.000 18.22363  ? 102 THR A C   1 
ATOM   777  O O   . THR A 1 102 ? 19.51103  2.01156   60.91104  1.000 16.59324  ? 102 THR A O   1 
ATOM   778  C CB  . THR A 1 102 ? 21.06759  -0.06067  62.64375  1.000 21.73483  ? 102 THR A CB  1 
ATOM   779  O OG1 . THR A 1 102 ? 21.37823  -1.19968  61.85462  1.000 27.12375  ? 102 THR A OG1 1 
ATOM   780  C CG2 . THR A 1 102 ? 21.53334  -0.26529  64.12676  1.000 20.62988  ? 102 THR A CG2 1 
ATOM   781  N N   . THR A 1 103 ? 18.53693  0.07140   60.26790  1.000 16.99301  ? 103 THR A N   1 
ATOM   782  C CA  . THR A 1 103 ? 18.02643  0.66112   59.01951  1.000 17.18661  ? 103 THR A CA  1 
ATOM   783  C C   . THR A 1 103 ? 16.91303  1.64907   59.33746  1.000 18.01837  ? 103 THR A C   1 
ATOM   784  O O   . THR A 1 103 ? 16.92194  2.80041   58.86881  1.000 17.57245  ? 103 THR A O   1 
ATOM   785  C CB  . THR A 1 103 ? 17.50666  -0.44345  58.07016  1.000 16.81298  ? 103 THR A CB  1 
ATOM   786  O OG1 . THR A 1 103 ? 18.61024  -1.20076  57.58060  1.000 15.07280  ? 103 THR A OG1 1 
ATOM   787  C CG2 . THR A 1 103 ? 16.76380  0.13957   56.81622  1.000 14.56564  ? 103 THR A CG2 1 
ATOM   788  N N   . LEU A 1 104 ? 15.98614  1.22849   60.19709  1.000 11.75570  ? 104 LEU A N   1 
ATOM   789  C CA  . LEU A 1 104 ? 14.81917  2.03556   60.55831  1.000 18.44144  ? 104 LEU A CA  1 
ATOM   790  C C   . LEU A 1 104 ? 15.20771  3.27169   61.36120  1.000 16.07111  ? 104 LEU A C   1 
ATOM   791  O O   . LEU A 1 104 ? 14.53851  4.30008   61.25763  1.000 17.32326  ? 104 LEU A O   1 
ATOM   792  C CB  . LEU A 1 104 ? 13.82104  1.16607   61.34614  1.000 14.08587  ? 104 LEU A CB  1 
ATOM   793  C CG  . LEU A 1 104 ? 13.17367  -0.00873  60.61307  1.000 19.11152  ? 104 LEU A CG  1 
ATOM   794  C CD1 . LEU A 1 104 ? 12.43363  -0.88699  61.62708  1.000 18.08667  ? 104 LEU A CD1 1 
ATOM   795  C CD2 . LEU A 1 104 ? 12.19533  0.47461   59.51200  1.000 14.79149  ? 104 LEU A CD2 1 
ATOM   796  N N   . ALA A 1 105 ? 16.26800  3.18525   62.17713  1.000 14.97879  ? 105 ALA A N   1 
ATOM   797  C CA  . ALA A 1 105 ? 16.70759  4.31999   62.97901  1.000 17.79442  ? 105 ALA A CA  1 
ATOM   798  C C   . ALA A 1 105 ? 17.40605  5.39178   62.14408  1.000 20.52116  ? 105 ALA A C   1 
ATOM   799  O O   . ALA A 1 105 ? 17.58927  6.50763   62.62710  1.000 18.50262  ? 105 ALA A O   1 
ATOM   800  C CB  . ALA A 1 105 ? 17.68241  3.85372   64.06594  1.000 17.52508  ? 105 ALA A CB  1 
ATOM   801  N N   . ASN A 1 106 ? 17.85651  5.06195   60.92932  1.000 13.00927  ? 106 ASN A N   1 
ATOM   802  C CA  . ASN A 1 106 ? 18.67765  5.97336   60.14587  1.000 16.55852  ? 106 ASN A CA  1 
ATOM   803  C C   . ASN A 1 106 ? 17.76802  7.03518   59.52962  1.000 18.42541  ? 106 ASN A C   1 
ATOM   804  O O   . ASN A 1 106 ? 16.87038  6.68559   58.76942  1.000 16.58317  ? 106 ASN A O   1 
ATOM   805  C CB  . ASN A 1 106 ? 19.44004  5.15732   59.08127  1.000 15.70569  ? 106 ASN A CB  1 
ATOM   806  C CG  . ASN A 1 106 ? 20.44714  5.97884   58.27957  1.000 17.93605  ? 106 ASN A CG  1 
ATOM   807  O OD1 . ASN A 1 106 ? 20.27047  7.16433   58.08963  1.000 18.58231  ? 106 ASN A OD1 1 
ATOM   808  N ND2 . ASN A 1 106 ? 21.47802  5.31141   57.75615  1.000 15.67439  ? 106 ASN A ND2 1 
ATOM   809  N N   . PRO A 1 107 ? 17.93205  8.32674   59.85207  1.000 18.39067  ? 107 PRO A N   1 
ATOM   810  C CA  . PRO A 1 107 ? 17.01691  9.32801   59.26835  1.000 18.11587  ? 107 PRO A CA  1 
ATOM   811  C C   . PRO A 1 107 ? 17.03795  9.35334   57.74811  1.000 15.52414  ? 107 PRO A C   1 
ATOM   812  O O   . PRO A 1 107 ? 16.06228  9.82496   57.14980  1.000 15.08961  ? 107 PRO A O   1 
ATOM   813  C CB  . PRO A 1 107 ? 17.49013  10.66988  59.86828  1.000 21.63062  ? 107 PRO A CB  1 
ATOM   814  C CG  . PRO A 1 107 ? 18.87992  10.42766  60.36498  1.000 27.82281  ? 107 PRO A CG  1 
ATOM   815  C CD  . PRO A 1 107 ? 19.00709  8.92967   60.66583  1.000 18.11359  ? 107 PRO A CD  1 
ATOM   816  N N   . LEU A 1 108 ? 18.12219  8.89682   57.10505  1.000 11.25685  ? 108 LEU A N   1 
ATOM   817  C CA  . LEU A 1 108 ? 18.18758  8.92925   55.65017  1.000 14.64877  ? 108 LEU A CA  1 
ATOM   818  C C   . LEU A 1 108 ? 17.08451  8.07266   55.00164  1.000 14.74059  ? 108 LEU A C   1 
ATOM   819  O O   . LEU A 1 108 ? 16.66206  8.36569   53.88016  1.000 13.81378  ? 108 LEU A O   1 
ATOM   820  C CB  . LEU A 1 108 ? 19.56621  8.45266   55.16616  1.000 13.43563  ? 108 LEU A CB  1 
ATOM   821  C CG  . LEU A 1 108 ? 19.76436  8.39099   53.63116  1.000 19.70421  ? 108 LEU A CG  1 
ATOM   822  C CD1 . LEU A 1 108 ? 19.59361  9.80431   52.97028  1.000 20.35586  ? 108 LEU A CD1 1 
ATOM   823  C CD2 . LEU A 1 108 ? 21.13077  7.79222   53.25063  1.000 14.76689  ? 108 LEU A CD2 1 
ATOM   824  N N   . LEU A 1 109 ? 16.63292  6.99769   55.66452  1.000 15.16340  ? 109 LEU A N   1 
ATOM   825  C CA  . LEU A 1 109 ? 15.57983  6.16025   55.06534  1.000 15.41060  ? 109 LEU A CA  1 
ATOM   826  C C   . LEU A 1 109 ? 14.29366  6.96954   54.92341  1.000 20.14810  ? 109 LEU A C   1 
ATOM   827  O O   . LEU A 1 109 ? 13.66339  6.98925   53.85670  1.000 14.74894  ? 109 LEU A O   1 
ATOM   828  C CB  . LEU A 1 109 ? 15.32203  4.91705   55.93676  1.000 14.10324  ? 109 LEU A CB  1 
ATOM   829  C CG  . LEU A 1 109 ? 14.30512  3.90681   55.32394  1.000 16.95396  ? 109 LEU A CG  1 
ATOM   830  C CD1 . LEU A 1 109 ? 14.86872  3.28508   54.09112  1.000 18.06507  ? 109 LEU A CD1 1 
ATOM   831  C CD2 . LEU A 1 109 ? 13.92574  2.86574   56.32449  1.000 17.54168  ? 109 LEU A CD2 1 
ATOM   832  N N   . THR A 1 110 ? 13.90436  7.66863   55.99245  1.000 14.79452  ? 110 THR A N   1 
ATOM   833  C CA  . THR A 1 110 ? 12.68819  8.49448   55.93535  1.000 16.18929  ? 110 THR A CA  1 
ATOM   834  C C   . THR A 1 110 ? 12.88094  9.64730   54.94775  1.000 17.59705  ? 110 THR A C   1 
ATOM   835  O O   . THR A 1 110 ? 12.00611  9.94542   54.13401  1.000 17.71723  ? 110 THR A O   1 
ATOM   836  C CB  . THR A 1 110 ? 12.37124  9.00632   57.34588  1.000 14.94292  ? 110 THR A CB  1 
ATOM   837  O OG1 . THR A 1 110 ? 11.94639  7.90169   58.19552  1.000 23.52893  ? 110 THR A OG1 1 
ATOM   838  C CG2 . THR A 1 110 ? 11.26077  10.06568  57.35404  1.000 20.71589  ? 110 THR A CG2 1 
ATOM   839  N N   . ARG A 1 111 ? 14.06759  10.23173  54.94344  1.000 16.57617  ? 111 ARG A N   1 
ATOM   840  C CA  . ARG A 1 111 ? 14.36560  11.32104  54.01511  1.000 19.66922  ? 111 ARG A CA  1 
ATOM   841  C C   . ARG A 1 111 ? 14.26021  10.87458  52.56579  1.000 17.20220  ? 111 ARG A C   1 
ATOM   842  O O   . ARG A 1 111 ? 13.66134  11.56466  51.74551  1.000 17.61664  ? 111 ARG A O   1 
ATOM   843  C CB  . ARG A 1 111 ? 15.76313  11.87095  54.27678  1.000 18.00377  ? 111 ARG A CB  1 
ATOM   844  C CG  . ARG A 1 111 ? 16.18021  12.96276  53.24437  1.000 27.73264  ? 111 ARG A CG  1 
ATOM   845  C CD  . ARG A 1 111 ? 17.63977  13.39357  53.52642  1.000 35.18433  ? 111 ARG A CD  1 
ATOM   846  N NE  . ARG A 1 111 ? 17.99485  14.72375  53.05047  1.000 49.35841  ? 111 ARG A NE  1 
ATOM   847  C CZ  . ARG A 1 111 ? 18.33170  15.01459  51.79897  1.000 69.28601  ? 111 ARG A CZ  1 
ATOM   848  N NH1 . ARG A 1 111 ? 18.25965  14.10960  50.83344  1.000 63.11794  ? 111 ARG A NH1 1 
ATOM   849  N NH2 . ARG A 1 111 ? 18.75258  16.24589  51.50876  1.000 65.55525  ? 111 ARG A NH2 1 
ATOM   850  N N   . LEU A 1 112 ? 14.83043  9.71589   52.22256  1.000 13.01638  ? 112 LEU A N   1 
ATOM   851  C CA  . LEU A 1 112 ? 14.68563  9.22437   50.85594  1.000 13.92745  ? 112 LEU A CA  1 
ATOM   852  C C   . LEU A 1 112 ? 13.22480  8.90882   50.51810  1.000 16.12127  ? 112 LEU A C   1 
ATOM   853  O O   . LEU A 1 112 ? 12.74881  9.21586   49.41668  1.000 14.77798  ? 112 LEU A O   1 
ATOM   854  C CB  . LEU A 1 112 ? 15.56314  7.98341   50.64047  1.000 17.48577  ? 112 LEU A CB  1 
ATOM   855  C CG  . LEU A 1 112 ? 17.08935  8.19058   50.62850  1.000 15.75165  ? 112 LEU A CG  1 
ATOM   856  C CD1 . LEU A 1 112 ? 17.82054  6.85741   50.40798  1.000 20.08671  ? 112 LEU A CD1 1 
ATOM   857  C CD2 . LEU A 1 112 ? 17.48002  9.22436   49.53880  1.000 17.43741  ? 112 LEU A CD2 1 
ATOM   858  N N   . LEU A 1 113 ? 12.48882  8.33551   51.45834  1.000 15.35092  ? 113 LEU A N   1 
ATOM   859  C CA  . LEU A 1 113 ? 11.11882  7.94987   51.15772  1.000 14.93363  ? 113 LEU A CA  1 
ATOM   860  C C   . LEU A 1 113 ? 10.29597  9.17888   50.78857  1.000 17.64552  ? 113 LEU A C   1 
ATOM   861  O O   . LEU A 1 113 ? 9.58663   9.19836   49.75988  1.000 14.73976  ? 113 LEU A O   1 
ATOM   862  C CB  . LEU A 1 113 ? 10.51288  7.18339   52.33191  1.000 13.94057  ? 113 LEU A CB  1 
ATOM   863  C CG  . LEU A 1 113 ? 9.07980   6.59231   52.06709  1.000 14.39201  ? 113 LEU A CG  1 
ATOM   864  C CD1 . LEU A 1 113 ? 8.80156   5.35095   52.93796  1.000 14.38452  ? 113 LEU A CD1 1 
ATOM   865  C CD2 . LEU A 1 113 ? 7.97118   7.67002   52.38252  1.000 16.69555  ? 113 LEU A CD2 1 
ATOM   866  N N   . ARG A 1 114 ? 10.48381  10.26523  51.53122  1.000 16.66414  ? 114 ARG A N   1 
ATOM   867  C CA  . ARG A 1 114 ? 9.66004   11.45320  51.27789  1.000 16.58048  ? 114 ARG A CA  1 
ATOM   868  C C   . ARG A 1 114 ? 10.18835  12.22838  50.09968  1.000 14.85446  ? 114 ARG A C   1 
ATOM   869  O O   . ARG A 1 114 ? 9.40470   12.70801  49.28069  1.000 19.33395  ? 114 ARG A O   1 
ATOM   870  C CB  . ARG A 1 114 ? 9.65299   12.36299  52.50627  1.000 17.17660  ? 114 ARG A CB  1 
ATOM   871  C CG  . ARG A 1 114 ? 9.02032   11.78891  53.72547  1.000 21.81532  ? 114 ARG A CG  1 
ATOM   872  C CD  . ARG A 1 114 ? 9.60197   12.69352  54.84679  1.000 22.73273  ? 114 ARG A CD  1 
ATOM   873  N NE  . ARG A 1 114 ? 8.83880   12.53260  56.03333  1.000 23.72166  ? 114 ARG A NE  1 
ATOM   874  C CZ  . ARG A 1 114 ? 9.17175   12.95745  57.24144  1.000 19.49031  ? 114 ARG A CZ  1 
ATOM   875  N NH1 . ARG A 1 114 ? 10.32926  13.56709  57.47890  1.000 18.45806  ? 114 ARG A NH1 1 
ATOM   876  N NH2 . ARG A 1 114 ? 8.31834   12.75499  58.22844  1.000 18.83079  ? 114 ARG A NH2 1 
ATOM   877  N N   . ALA A 1 115 ? 11.51679  12.37822  50.01375  1.000 13.98065  ? 115 ALA A N   1 
ATOM   878  C CA  . ALA A 1 115 ? 12.11491  13.15829  48.93473  1.000 16.72413  ? 115 ALA A CA  1 
ATOM   879  C C   . ALA A 1 115 ? 11.91919  12.50011  47.57835  1.000 21.51510  ? 115 ALA A C   1 
ATOM   880  O O   . ALA A 1 115 ? 11.65363  13.19935  46.59489  1.000 17.76918  ? 115 ALA A O   1 
ATOM   881  C CB  . ALA A 1 115 ? 13.60434  13.37865  49.17735  1.000 20.92414  ? 115 ALA A CB  1 
ATOM   882  N N   . ASP A 1 116 ? 12.02967  11.15950  47.49007  1.000 16.11920  ? 116 ASP A N   1 
ATOM   883  C CA  . ASP A 1 116 ? 11.87132  10.53246  46.16892  1.000 15.68436  ? 116 ASP A CA  1 
ATOM   884  C C   . ASP A 1 116 ? 10.49106  10.81696  45.61263  1.000 14.80694  ? 116 ASP A C   1 
ATOM   885  O O   . ASP A 1 116 ? 10.33001  11.01072  44.40122  1.000 17.22007  ? 116 ASP A O   1 
ATOM   886  C CB  . ASP A 1 116 ? 12.09077  9.01526   46.21389  1.000 11.87493  ? 116 ASP A CB  1 
ATOM   887  C CG  . ASP A 1 116 ? 13.57491  8.60977   46.54260  1.000 18.11972  ? 116 ASP A CG  1 
ATOM   888  O OD1 . ASP A 1 116 ? 14.50794  9.39120   46.27027  1.000 16.26577  ? 116 ASP A OD1 1 
ATOM   889  O OD2 . ASP A 1 116 ? 13.78909  7.51489   47.11558  1.000 18.36935  ? 116 ASP A OD2 1 
ATOM   890  N N   . PHE A 1 117 ? 9.48465   10.84366  46.49055  1.000 13.31578  ? 117 PHE A N   1 
ATOM   891  C CA  . PHE A 1 117 ? 8.08883   10.96920  46.05214  1.000 14.86214  ? 117 PHE A CA  1 
ATOM   892  C C   . PHE A 1 117 ? 7.84916   12.25706  45.25984  1.000 18.08338  ? 117 PHE A C   1 
ATOM   893  O O   . PHE A 1 117 ? 6.96878   12.30759  44.37681  1.000 17.14239  ? 117 PHE A O   1 
ATOM   894  C CB  . PHE A 1 117 ? 7.17309   10.93648  47.27143  1.000 13.95087  ? 117 PHE A CB  1 
ATOM   895  C CG  . PHE A 1 117 ? 5.71970   10.96408  46.90389  1.000 15.79141  ? 117 PHE A CG  1 
ATOM   896  C CD1 . PHE A 1 117 ? 5.08008   9.80058   46.50549  1.000 13.94310  ? 117 PHE A CD1 1 
ATOM   897  C CD2 . PHE A 1 117 ? 5.01579   12.17490  46.89960  1.000 19.47076  ? 117 PHE A CD2 1 
ATOM   898  C CE1 . PHE A 1 117 ? 3.71789   9.82882   46.15066  1.000 15.95475  ? 117 PHE A CE1 1 
ATOM   899  C CE2 . PHE A 1 117 ? 3.68678   12.21468  46.52987  1.000 18.18515  ? 117 PHE A CE2 1 
ATOM   900  C CZ  . PHE A 1 117 ? 3.02935   11.03697  46.15597  1.000 18.53458  ? 117 PHE A CZ  1 
ATOM   901  N N   A GLU A 1 118 ? 8.60117   13.30655  45.56868  0.586 16.07581  ? 118 GLU A N   1 
ATOM   902  N N   B GLU A 1 118 ? 8.59748   13.31120  45.59269  0.414 17.83911  ? 118 GLU A N   1 
ATOM   903  C CA  A GLU A 1 118 ? 8.40637   14.58666  44.91436  0.586 20.83911  ? 118 GLU A CA  1 
ATOM   904  C CA  B GLU A 1 118 ? 8.46049   14.59463  44.92327  0.414 20.87327  ? 118 GLU A CA  1 
ATOM   905  C C   A GLU A 1 118 ? 8.83269   14.56489  43.45358  0.586 22.15327  ? 118 GLU A C   1 
ATOM   906  C C   B GLU A 1 118 ? 8.69386   14.48432  43.42849  0.414 22.03290  ? 118 GLU A C   1 
ATOM   907  O O   A GLU A 1 118 ? 8.63461   15.56797  42.75190  0.586 21.61560  ? 118 GLU A O   1 
ATOM   908  O O   B GLU A 1 118 ? 8.22890   15.34626  42.67792  0.414 21.12782  ? 118 GLU A O   1 
ATOM   909  C CB  A GLU A 1 118 ? 9.16925   15.66756  45.68584  0.586 23.68852  ? 118 GLU A CB  1 
ATOM   910  C CB  B GLU A 1 118 ? 9.45338   15.61300  45.50159  0.414 23.57446  ? 118 GLU A CB  1 
ATOM   911  C CG  A GLU A 1 118 ? 8.61605   15.90041  47.09311  0.586 24.43760  ? 118 GLU A CG  1 
ATOM   912  C CG  B GLU A 1 118 ? 9.36668   15.83112  46.99900  0.414 25.24966  ? 118 GLU A CG  1 
ATOM   913  C CD  A GLU A 1 118 ? 7.15270   16.31346  47.07046  0.586 26.44084  ? 118 GLU A CD  1 
ATOM   914  C CD  B GLU A 1 118 ? 10.33312  16.90349  47.48309  0.414 34.12087  ? 118 GLU A CD  1 
ATOM   915  O OE1 A GLU A 1 118 ? 6.77234   17.18256  46.25753  0.586 32.82342  ? 118 GLU A OE1 1 
ATOM   916  O OE1 B GLU A 1 118 ? 11.06922  17.48681  46.64815  0.414 33.04227  ? 118 GLU A OE1 1 
ATOM   917  O OE2 A GLU A 1 118 ? 6.36620   15.76782  47.85008  0.586 26.32003  ? 118 GLU A OE2 1 
ATOM   918  O OE2 B GLU A 1 118 ? 10.36961  17.15774  48.71198  0.414 39.54601  ? 118 GLU A OE2 1 
ATOM   919  N N   . ASN A 1 119 ? 9.42011   13.46306  42.97825  1.000 16.06208  ? 119 ASN A N   1 
ATOM   920  C CA  . ASN A 1 119 ? 9.78492   13.33855  41.57096  1.000 15.79362  ? 119 ASN A CA  1 
ATOM   921  C C   . ASN A 1 119 ? 8.71728   12.64844  40.74045  1.000 16.58535  ? 119 ASN A C   1 
ATOM   922  O O   . ASN A 1 119 ? 8.94359   12.39246  39.56011  1.000 20.47032  ? 119 ASN A O   1 
ATOM   923  C CB  . ASN A 1 119 ? 11.10451  12.55794  41.45628  1.000 15.64141  ? 119 ASN A CB  1 
ATOM   924  C CG  . ASN A 1 119 ? 12.24831  13.30459  42.08444  1.000 21.13192  ? 119 ASN A CG  1 
ATOM   925  O OD1 . ASN A 1 119 ? 12.76277  14.22355  41.48419  1.000 23.02580  ? 119 ASN A OD1 1 
ATOM   926  N ND2 . ASN A 1 119 ? 12.62049  12.94996  43.32190  1.000 15.18970  ? 119 ASN A ND2 1 
ATOM   927  N N   . PHE A 1 120 ? 7.60725   12.27632  41.33366  1.000 12.23271  ? 120 PHE A N   1 
ATOM   928  C CA  . PHE A 1 120 ? 6.60851   11.49473  40.60178  1.000 12.18068  ? 120 PHE A CA  1 
ATOM   929  C C   . PHE A 1 120 ? 5.49638   12.42797  40.09350  1.000 19.50086  ? 120 PHE A C   1 
ATOM   930  O O   . PHE A 1 120 ? 5.03864   13.29612  40.84299  1.000 16.77094  ? 120 PHE A O   1 
ATOM   931  C CB  . PHE A 1 120 ? 5.95725   10.41843  41.47879  1.000 12.28518  ? 120 PHE A CB  1 
ATOM   932  C CG  . PHE A 1 120 ? 6.95272   9.40939   42.08361  1.000 13.22246  ? 120 PHE A CG  1 
ATOM   933  C CD1 . PHE A 1 120 ? 8.06710   8.99952   41.36090  1.000 12.63738  ? 120 PHE A CD1 1 
ATOM   934  C CD2 . PHE A 1 120 ? 6.74508   8.90276   43.37297  1.000 13.13887  ? 120 PHE A CD2 1 
ATOM   935  C CE1 . PHE A 1 120 ? 9.00411   8.04864   41.92176  1.000 12.45840  ? 120 PHE A CE1 1 
ATOM   936  C CE2 . PHE A 1 120 ? 7.65603   7.96934   43.95524  1.000 12.87671  ? 120 PHE A CE2 1 
ATOM   937  C CZ  . PHE A 1 120 ? 8.79027   7.55212   43.20027  1.000 9.80947   ? 120 PHE A CZ  1 
ATOM   938  N N   . PRO A 1 121 ? 5.01853   12.26084  38.85162  1.000 19.36680  ? 121 PRO A N   1 
ATOM   939  C CA  . PRO A 1 121 ? 3.87611   13.11428  38.35473  1.000 20.08542  ? 121 PRO A CA  1 
ATOM   940  C C   . PRO A 1 121 ? 2.55070   12.59310  38.90614  1.000 17.93416  ? 121 PRO A C   1 
ATOM   941  O O   . PRO A 1 121 ? 1.79886   11.84885  38.30704  1.000 20.36677  ? 121 PRO A O   1 
ATOM   942  C CB  . PRO A 1 121 ? 3.99180   12.97320  36.83378  1.000 21.66076  ? 121 PRO A CB  1 
ATOM   943  C CG  . PRO A 1 121 ? 4.51206   11.48951  36.63838  1.000 19.59896  ? 121 PRO A CG  1 
ATOM   944  C CD  . PRO A 1 121 ? 5.47835   11.27048  37.84395  1.000 15.90465  ? 121 PRO A CD  1 
ATOM   945  N N   . VAL A 1 122 ? 2.24145   12.94384  40.14244  1.000 20.35233  ? 122 VAL A N   1 
ATOM   946  C CA  . VAL A 1 122 ? 0.98693   12.44544  40.72912  1.000 25.21752  ? 122 VAL A CA  1 
ATOM   947  C C   . VAL A 1 122 ? -0.19058  12.98655  39.91432  1.000 24.86296  ? 122 VAL A C   1 
ATOM   948  O O   . VAL A 1 122 ? -0.23585  14.18436  39.64430  1.000 22.19280  ? 122 VAL A O   1 
ATOM   949  C CB  . VAL A 1 122 ? 0.88847   12.88477  42.20783  1.000 22.50538  ? 122 VAL A CB  1 
ATOM   950  C CG1 . VAL A 1 122 ? -0.41263  12.42782  42.83254  1.000 24.76224  ? 122 VAL A CG1 1 
ATOM   951  C CG2 . VAL A 1 122 ? 2.05557   12.29493  43.00527  1.000 26.25449  ? 122 VAL A CG2 1 
ATOM   952  N N   . PRO A 1 123 ? -1.14949  12.16792  39.48021  1.000 24.22710  ? 123 PRO A N   1 
ATOM   953  C CA  . PRO A 1 123 ? -2.14630  12.67411  38.51121  1.000 34.03639  ? 123 PRO A CA  1 
ATOM   954  C C   . PRO A 1 123 ? -3.20037  13.61769  39.10169  1.000 39.17601  ? 123 PRO A C   1 
ATOM   955  O O   . PRO A 1 123 ? -3.73932  14.45370  38.36814  1.000 36.33919  ? 123 PRO A O   1 
ATOM   956  C CB  . PRO A 1 123 ? -2.79243  11.39207  37.96212  1.000 32.46402  ? 123 PRO A CB  1 
ATOM   957  C CG  . PRO A 1 123 ? -2.51758  10.35633  38.94339  1.000 30.98746  ? 123 PRO A CG  1 
ATOM   958  C CD  . PRO A 1 123 ? -1.24514  10.71592  39.67047  1.000 26.24505  ? 123 PRO A CD  1 
ATOM   959  N N   . GLU A 1 124 ? -3.51647  13.51367  40.38590  1.000 31.89319  ? 124 GLU A N   1 
ATOM   960  C CA  . GLU A 1 124 ? -4.56835  14.30496  41.02187  1.000 29.43471  ? 124 GLU A CA  1 
ATOM   961  C C   . GLU A 1 124 ? -4.00891  14.90103  42.30747  1.000 32.19287  ? 124 GLU A C   1 
ATOM   962  O O   . GLU A 1 124 ? -3.37103  14.19099  43.09672  1.000 28.49334  ? 124 GLU A O   1 
ATOM   963  C CB  . GLU A 1 124 ? -5.79491  13.43217  41.31636  1.000 27.18208  ? 124 GLU A CB  1 
ATOM   964  C CG  . GLU A 1 124 ? -6.38042  12.68069  40.07845  1.000 33.14980  ? 124 GLU A CG  1 
ATOM   965  C CD  . GLU A 1 124 ? -7.07312  13.61061  39.06093  1.000 36.94381  ? 124 GLU A CD  1 
ATOM   966  O OE1 . GLU A 1 124 ? -7.33193  14.80119  39.39716  1.000 32.95699  ? 124 GLU A OE1 1 
ATOM   967  O OE2 . GLU A 1 124 ? -7.33438  13.13375  37.92430  1.000 37.51499  ? 124 GLU A OE2 1 
ATOM   968  N N   . GLU A 1 125 ? -4.22444  16.19863  42.51134  1.000 30.42575  ? 125 GLU A N   1 
ATOM   969  C CA  . GLU A 1 125 ? -3.65958  16.86191  43.68192  1.000 30.45274  ? 125 GLU A CA  1 
ATOM   970  C C   . GLU A 1 125 ? -4.29565  16.34746  44.97281  1.000 32.31177  ? 125 GLU A C   1 
ATOM   971  O O   . GLU A 1 125 ? -3.64530  16.32854  46.02530  1.000 30.95654  ? 125 GLU A O   1 
ATOM   972  C CB  . GLU A 1 125 ? -3.82642  18.37521  43.54388  1.000 36.51096  ? 125 GLU A CB  1 
ATOM   973  C CG  . GLU A 1 125 ? -4.36278  19.07156  44.78002  1.000 47.69975  ? 125 GLU A CG  1 
ATOM   974  C CD  . GLU A 1 125 ? -3.27473  19.79131  45.55138  1.000 65.00601  ? 125 GLU A CD  1 
ATOM   975  O OE1 . GLU A 1 125 ? -2.08528  19.56134  45.23652  1.000 79.41601  ? 125 GLU A OE1 1 
ATOM   976  O OE2 . GLU A 1 125 ? -3.60645  20.58870  46.46078  1.000 59.82818  ? 125 GLU A OE2 1 
ATOM   977  N N   . SER A 1 126 ? -5.54271  15.89178  44.90893  1.000 25.61299  ? 126 SER A N   1 
ATOM   978  C CA  . SER A 1 126 ? -6.17475  15.33686  46.09570  1.000 29.97907  ? 126 SER A CA  1 
ATOM   979  C C   . SER A 1 126 ? -5.48115  14.06539  46.60051  1.000 31.00770  ? 126 SER A C   1 
ATOM   980  O O   . SER A 1 126 ? -5.66416  13.70314  47.76521  1.000 24.72882  ? 126 SER A O   1 
ATOM   981  C CB  . SER A 1 126 ? -7.63995  15.02653  45.82626  1.000 27.03736  ? 126 SER A CB  1 
ATOM   982  O OG  . SER A 1 126 ? -7.82880  13.85619  45.03018  1.000 29.21299  ? 126 SER A OG  1 
ATOM   983  N N   . TRP A 1 127 ? -4.72752  13.36322  45.75117  1.000 26.96610  ? 127 TRP A N   1 
ATOM   984  C CA  . TRP A 1 127 ? -4.05642  12.13111  46.18217  1.000 21.28344  ? 127 TRP A CA  1 
ATOM   985  C C   . TRP A 1 127 ? -2.98170  12.39596  47.21647  1.000 25.86426  ? 127 TRP A C   1 
ATOM   986  O O   . TRP A 1 127 ? -2.53466  11.45804  47.89342  1.000 21.86759  ? 127 TRP A O   1 
ATOM   987  C CB  . TRP A 1 127 ? -3.40691  11.40862  44.99571  1.000 17.80391  ? 127 TRP A CB  1 
ATOM   988  C CG  . TRP A 1 127 ? -4.42084  10.84781  44.02456  1.000 24.63405  ? 127 TRP A CG  1 
ATOM   989  C CD1 . TRP A 1 127 ? -5.74905  11.19207  43.92652  1.000 27.73001  ? 127 TRP A CD1 1 
ATOM   990  C CD2 . TRP A 1 127 ? -4.19023  9.85658   43.00693  1.000 31.49375  ? 127 TRP A CD2 1 
ATOM   991  N NE1 . TRP A 1 127 ? -6.35687  10.47489  42.92197  1.000 30.36161  ? 127 TRP A NE1 1 
ATOM   992  C CE2 . TRP A 1 127 ? -5.42407  9.65987   42.32814  1.000 31.29307  ? 127 TRP A CE2 1 
ATOM   993  C CE3 . TRP A 1 127 ? -3.06331  9.11219   42.60119  1.000 24.84450  ? 127 TRP A CE3 1 
ATOM   994  C CZ2 . TRP A 1 127 ? -5.56631  8.74360   41.27870  1.000 32.92300  ? 127 TRP A CZ2 1 
ATOM   995  C CZ3 . TRP A 1 127 ? -3.21101  8.20198   41.52839  1.000 26.36513  ? 127 TRP A CZ3 1 
ATOM   996  C CH2 . TRP A 1 127 ? -4.44685  8.02494   40.89091  1.000 31.99807  ? 127 TRP A CH2 1 
ATOM   997  N N   . LEU A 1 128 ? -2.50043  13.62918  47.29852  1.000 20.46443  ? 128 LEU A N   1 
ATOM   998  C CA  . LEU A 1 128 ? -1.49834  13.94977  48.28653  1.000 21.37877  ? 128 LEU A CA  1 
ATOM   999  C C   . LEU A 1 128 ? -2.03424  13.83143  49.71194  1.000 28.81418  ? 128 LEU A C   1 
ATOM   1000 O O   . LEU A 1 128 ? -1.23386  13.79100  50.65224  1.000 24.73042  ? 128 LEU A O   1 
ATOM   1001 C CB  . LEU A 1 128 ? -0.98984  15.34750  48.04183  1.000 22.75388  ? 128 LEU A CB  1 
ATOM   1002 C CG  . LEU A 1 128 ? -0.40640  15.56012  46.65373  1.000 30.15990  ? 128 LEU A CG  1 
ATOM   1003 C CD1 . LEU A 1 128 ? 0.09294   16.98261  46.53672  1.000 35.37709  ? 128 LEU A CD1 1 
ATOM   1004 C CD2 . LEU A 1 128 ? 0.71493   14.56305  46.36399  1.000 26.38106  ? 128 LEU A CD2 1 
ATOM   1005 N N   . ASP A 1 129 ? -3.36500  13.78965  49.88899  1.000 25.67093  ? 129 ASP A N   1 
ATOM   1006 C CA  . ASP A 1 129 ? -3.99210  13.67065  51.20939  1.000 26.08041  ? 129 ASP A CA  1 
ATOM   1007 C C   . ASP A 1 129 ? -4.39549  12.25897  51.53520  1.000 26.80487  ? 129 ASP A C   1 
ATOM   1008 O O   . ASP A 1 129 ? -4.95145  12.03316  52.62163  1.000 25.34575  ? 129 ASP A O   1 
ATOM   1009 C CB  . ASP A 1 129 ? -5.28366  14.50719  51.30529  1.000 29.81243  ? 129 ASP A CB  1 
ATOM   1010 C CG  . ASP A 1 129 ? -5.05361  15.95881  51.10977  1.000 34.34365  ? 129 ASP A CG  1 
ATOM   1011 O OD1 . ASP A 1 129 ? -4.28955  16.53286  51.90532  1.000 36.53522  ? 129 ASP A OD1 1 
ATOM   1012 O OD2 . ASP A 1 129 ? -5.63259  16.52874  50.14596  1.000 42.41063  ? 129 ASP A OD2 1 
ATOM   1013 N N   . ASP A 1 130 ? -4.24108  11.33205  50.57578  1.000 19.58331  ? 130 ASP A N   1 
ATOM   1014 C CA  . ASP A 1 130 ? -4.59948  9.94886   50.77960  1.000 24.77503  ? 130 ASP A CA  1 
ATOM   1015 C C   . ASP A 1 130 ? -3.36523  9.20676   51.26863  1.000 18.51495  ? 130 ASP A C   1 
ATOM   1016 O O   . ASP A 1 130 ? -2.23411  9.63829   51.03160  1.000 19.15489  ? 130 ASP A O   1 
ATOM   1017 C CB  . ASP A 1 130 ? -5.08954  9.30697   49.46194  1.000 24.85863  ? 130 ASP A CB  1 
ATOM   1018 C CG  . ASP A 1 130 ? -6.36105  9.98221   48.88910  1.000 29.04454  ? 130 ASP A CG  1 
ATOM   1019 O OD1 . ASP A 1 130 ? -7.26622  10.28523  49.68994  1.000 27.95590  ? 130 ASP A OD1 1 
ATOM   1020 O OD2 . ASP A 1 130 ? -6.43318  10.18877  47.64628  1.000 24.70022  ? 130 ASP A OD2 1 
ATOM   1021 N N   . PRO A 1 131 ? -3.55499  8.10184   51.95337  1.000 18.54084  ? 131 PRO A N   1 
ATOM   1022 C CA  . PRO A 1 131 ? -2.42260  7.23377   52.24949  1.000 17.37529  ? 131 PRO A CA  1 
ATOM   1023 C C   . PRO A 1 131 ? -1.88567  6.60070   50.97386  1.000 18.71824  ? 131 PRO A C   1 
ATOM   1024 O O   . PRO A 1 131 ? -2.62691  6.29156   50.02484  1.000 18.26771  ? 131 PRO A O   1 
ATOM   1025 C CB  . PRO A 1 131 ? -3.03246  6.17447   53.17869  1.000 19.38788  ? 131 PRO A CB  1 
ATOM   1026 C CG  . PRO A 1 131 ? -4.35743  6.81495   53.65538  1.000 24.33368  ? 131 PRO A CG  1 
ATOM   1027 C CD  . PRO A 1 131 ? -4.80831  7.56621   52.48804  1.000 22.17978  ? 131 PRO A CD  1 
ATOM   1028 N N   . TRP A 1 132 ? -0.57882  6.38869   50.98147  1.000 17.34019  ? 132 TRP A N   1 
ATOM   1029 C CA  . TRP A 1 132 ? 0.12414   5.55722   50.01045  1.000 14.74094  ? 132 TRP A CA  1 
ATOM   1030 C C   . TRP A 1 132 ? 0.80887   4.42233   50.75572  1.000 16.12280  ? 132 TRP A C   1 
ATOM   1031 O O   . TRP A 1 132 ? 1.33203   4.61622   51.85763  1.000 15.93227  ? 132 TRP A O   1 
ATOM   1032 C CB  . TRP A 1 132 ? 1.18308   6.33636   49.23877  1.000 12.17308  ? 132 TRP A CB  1 
ATOM   1033 C CG  . TRP A 1 132 ? 0.60412   7.36979   48.39189  1.000 14.80147  ? 132 TRP A CG  1 
ATOM   1034 C CD1 . TRP A 1 132 ? -0.19108  8.44131   48.80939  1.000 16.56424  ? 132 TRP A CD1 1 
ATOM   1035 C CD2 . TRP A 1 132 ? 0.74071   7.49568   46.97733  1.000 13.37512  ? 132 TRP A CD2 1 
ATOM   1036 N NE1 . TRP A 1 132 ? -0.51734  9.22465   47.72020  1.000 16.87203  ? 132 TRP A NE1 1 
ATOM   1037 C CE2 . TRP A 1 132 ? 0.00420   8.65236   46.58393  1.000 16.77108  ? 132 TRP A CE2 1 
ATOM   1038 C CE3 . TRP A 1 132 ? 1.38442   6.74363   46.00144  1.000 13.48901  ? 132 TRP A CE3 1 
ATOM   1039 C CZ2 . TRP A 1 132 ? -0.08130  9.06138   45.26785  1.000 15.33632  ? 132 TRP A CZ2 1 
ATOM   1040 C CZ3 . TRP A 1 132 ? 1.29028   7.14739   44.66645  1.000 13.71484  ? 132 TRP A CZ3 1 
ATOM   1041 C CH2 . TRP A 1 132 ? 0.54293   8.28664   44.31676  1.000 17.04856  ? 132 TRP A CH2 1 
ATOM   1042 N N   . ASP A 1 133 ? 0.80292   3.25042   50.15818  1.000 14.66803  ? 133 ASP A N   1 
ATOM   1043 C CA  . ASP A 1 133 ? 1.60349   2.14265   50.65196  1.000 12.32281  ? 133 ASP A CA  1 
ATOM   1044 C C   . ASP A 1 133 ? 2.95934   2.23310   49.97722  1.000 14.20422  ? 133 ASP A C   1 
ATOM   1045 O O   . ASP A 1 133 ? 3.01870   2.37687   48.75189  1.000 12.99777  ? 133 ASP A O   1 
ATOM   1046 C CB  . ASP A 1 133 ? 0.91572   0.81370   50.31659  1.000 19.27986  ? 133 ASP A CB  1 
ATOM   1047 C CG  . ASP A 1 133 ? 1.80600   -0.38700  50.65004  1.000 20.15732  ? 133 ASP A CG  1 
ATOM   1048 O OD1 . ASP A 1 133 ? 2.14270   -0.56277  51.83973  1.000 21.22661  ? 133 ASP A OD1 1 
ATOM   1049 O OD2 . ASP A 1 133 ? 2.22738   -1.07599  49.72567  1.000 23.33068  ? 133 ASP A OD2 1 
ATOM   1050 N N   . VAL A 1 134 ? 4.04481   2.18232   50.76668  1.000 13.97295  ? 134 VAL A N   1 
ATOM   1051 C CA  . VAL A 1 134 ? 5.40965   2.25809   50.22083  1.000 13.75891  ? 134 VAL A CA  1 
ATOM   1052 C C   . VAL A 1 134 ? 6.12034   0.96447   50.60020  1.000 13.68372  ? 134 VAL A C   1 
ATOM   1053 O O   . VAL A 1 134 ? 6.32661   0.69601   51.78548  1.000 12.66498  ? 134 VAL A O   1 
ATOM   1054 C CB  . VAL A 1 134 ? 6.17979   3.48084   50.72060  1.000 14.81785  ? 134 VAL A CB  1 
ATOM   1055 C CG1 . VAL A 1 134 ? 7.56872   3.58648   49.91534  1.000 11.41880  ? 134 VAL A CG1 1 
ATOM   1056 C CG2 . VAL A 1 134 ? 5.29834   4.76939   50.51160  1.000 14.72793  ? 134 VAL A CG2 1 
ATOM   1057 N N   . GLN A 1 135 ? 6.40996   0.12616   49.61538  1.000 12.54868  ? 135 GLN A N   1 
ATOM   1058 C CA  . GLN A 1 135 ? 7.15928   -1.10984  49.86704  1.000 11.03176  ? 135 GLN A CA  1 
ATOM   1059 C C   . GLN A 1 135 ? 8.63442   -0.79519  49.72994  1.000 14.87074  ? 135 GLN A C   1 
ATOM   1060 O O   . GLN A 1 135 ? 9.04353   -0.09829  48.78682  1.000 14.68800  ? 135 GLN A O   1 
ATOM   1061 C CB  . GLN A 1 135 ? 6.77409   -2.20377  48.85740  1.000 16.19917  ? 135 GLN A CB  1 
ATOM   1062 C CG  . GLN A 1 135 ? 5.33296   -2.60605  48.94451  1.000 17.30361  ? 135 GLN A CG  1 
ATOM   1063 C CD  . GLN A 1 135 ? 4.96904   -3.57600  47.87390  1.000 21.62167  ? 135 GLN A CD  1 
ATOM   1064 O OE1 . GLN A 1 135 ? 5.31658   -4.74996  47.97670  1.000 16.37181  ? 135 GLN A OE1 1 
ATOM   1065 N NE2 . GLN A 1 135 ? 4.26834   -3.10735  46.83950  1.000 18.15305  ? 135 GLN A NE2 1 
ATOM   1066 N N   . CYS A 1 136 ? 9.42298   -1.24166  50.70359  1.000 13.27630  ? 136 CYS A N   1 
ATOM   1067 C CA  . CYS A 1 136 ? 10.81894  -0.85530  50.79684  1.000 11.41186  ? 136 CYS A CA  1 
ATOM   1068 C C   . CYS A 1 136 ? 11.66832  -2.12802  50.75866  1.000 15.90873  ? 136 CYS A C   1 
ATOM   1069 O O   . CYS A 1 136 ? 11.50681  -2.99564  51.62745  1.000 14.52486  ? 136 CYS A O   1 
ATOM   1070 C CB  . CYS A 1 136 ? 11.03153  -0.09557  52.09657  1.000 12.77836  ? 136 CYS A CB  1 
ATOM   1071 S SG  . CYS A 1 136 ? 12.72378  0.40229   52.34446  1.000 21.23222  ? 136 CYS A SG  1 
ATOM   1072 N N   . HIS A 1 137 ? 12.52341  -2.26378  49.73608  1.000 14.30884  ? 137 HIS A N   1 
ATOM   1073 C CA  . HIS A 1 137 ? 13.33463  -3.47336  49.51113  1.000 14.46131  ? 137 HIS A CA  1 
ATOM   1074 C C   . HIS A 1 137 ? 14.82052  -3.16366  49.65469  1.000 15.64762  ? 137 HIS A C   1 
ATOM   1075 O O   . HIS A 1 137 ? 15.32895  -2.27523  48.98295  1.000 13.48119  ? 137 HIS A O   1 
ATOM   1076 C CB  . HIS A 1 137 ? 13.14171  -4.04743  48.09988  1.000 16.34881  ? 137 HIS A CB  1 
ATOM   1077 C CG  . HIS A 1 137 ? 11.71239  -4.25454  47.70453  1.000 21.56760  ? 137 HIS A CG  1 
ATOM   1078 N ND1 . HIS A 1 137 ? 11.07754  -5.47807  47.81684  1.000 20.78756  ? 137 HIS A ND1 1 
ATOM   1079 C CD2 . HIS A 1 137 ? 10.79097  -3.38749  47.20886  1.000 16.40077  ? 137 HIS A CD2 1 
ATOM   1080 C CE1 . HIS A 1 137 ? 9.81931   -5.34795  47.40927  1.000 16.38689  ? 137 HIS A CE1 1 
ATOM   1081 N NE2 . HIS A 1 137 ? 9.62601   -4.09856  47.02181  1.000 17.41676  ? 137 HIS A NE2 1 
ATOM   1082 N N   . GLN A 1 138 ? 15.54137  -3.95348  50.44247  1.000 14.66568  ? 138 GLN A N   1 
ATOM   1083 C CA  . GLN A 1 138 ? 16.99703  -3.95920  50.37561  1.000 14.64915  ? 138 GLN A CA  1 
ATOM   1084 C C   . GLN A 1 138 ? 17.37524  -5.23685  49.65735  1.000 17.08749  ? 138 GLN A C   1 
ATOM   1085 O O   . GLN A 1 138 ? 17.03705  -6.32398  50.14172  1.000 16.66148  ? 138 GLN A O   1 
ATOM   1086 C CB  . GLN A 1 138 ? 17.65888  -3.93827  51.75677  1.000 13.94687  ? 138 GLN A CB  1 
ATOM   1087 C CG  . GLN A 1 138 ? 17.29226  -2.69027  52.63095  1.000 18.43926  ? 138 GLN A CG  1 
ATOM   1088 C CD  . GLN A 1 138 ? 17.83557  -2.78446  54.07018  1.000 17.35701  ? 138 GLN A CD  1 
ATOM   1089 O OE1 . GLN A 1 138 ? 17.50156  -3.73099  54.80128  1.000 17.54952  ? 138 GLN A OE1 1 
ATOM   1090 N NE2 . GLN A 1 138 ? 18.64976  -1.78801  54.49154  1.000 18.89577  ? 138 GLN A NE2 1 
ATOM   1091 N N   . PHE A 1 139 ? 18.02599  -5.10971  48.49140  1.000 14.27957  ? 139 PHE A N   1 
ATOM   1092 C CA  . PHE A 1 139 ? 18.44122  -6.25611  47.68762  1.000 12.83142  ? 139 PHE A CA  1 
ATOM   1093 C C   . PHE A 1 139 ? 19.96145  -6.28372  47.62732  1.000 20.55076  ? 139 PHE A C   1 
ATOM   1094 O O   . PHE A 1 139 ? 20.57905  -5.26501  47.25323  1.000 11.96602  ? 139 PHE A O   1 
ATOM   1095 C CB  . PHE A 1 139 ? 17.95348  -6.14446  46.24537  1.000 20.86438  ? 139 PHE A CB  1 
ATOM   1096 C CG  . PHE A 1 139 ? 16.61006  -6.67901  45.99903  1.000 24.11606  ? 139 PHE A CG  1 
ATOM   1097 C CD1 . PHE A 1 139 ? 16.40225  -8.03158  45.93708  1.000 27.27874  ? 139 PHE A CD1 1 
ATOM   1098 C CD2 . PHE A 1 139 ? 15.54496  -5.81671  45.77747  1.000 27.09483  ? 139 PHE A CD2 1 
ATOM   1099 C CE1 . PHE A 1 139 ? 15.13131  -8.53818  45.71077  1.000 40.00222  ? 139 PHE A CE1 1 
ATOM   1100 C CE2 . PHE A 1 139 ? 14.25251  -6.31847  45.53876  1.000 29.17754  ? 139 PHE A CE2 1 
ATOM   1101 C CZ  . PHE A 1 139 ? 14.05282  -7.66890  45.51327  1.000 38.11701  ? 139 PHE A CZ  1 
ATOM   1102 N N   . ARG A 1 140 ? 20.55917  -7.46019  47.88686  1.000 15.87304  ? 140 ARG A N   1 
ATOM   1103 C CA  . ARG A 1 140 ? 21.95886  -7.70317  47.55933  1.000 18.44269  ? 140 ARG A CA  1 
ATOM   1104 C C   . ARG A 1 140 ? 21.97614  -8.84438  46.55034  1.000 22.55664  ? 140 ARG A C   1 
ATOM   1105 O O   . ARG A 1 140 ? 21.39510  -9.90124  46.80994  1.000 19.35445  ? 140 ARG A O   1 
ATOM   1106 C CB  . ARG A 1 140 ? 22.80266  -8.03856  48.80497  1.000 18.92740  ? 140 ARG A CB  1 
ATOM   1107 C CG  . ARG A 1 140 ? 24.20714  -8.61725  48.44425  1.000 19.25788  ? 140 ARG A CG  1 
ATOM   1108 C CD  . ARG A 1 140 ? 25.16511  -8.58075  49.61368  1.000 18.19358  ? 140 ARG A CD  1 
ATOM   1109 N NE  . ARG A 1 140 ? 25.75436  -7.25305  49.77648  1.000 15.64449  ? 140 ARG A NE  1 
ATOM   1110 C CZ  . ARG A 1 140 ? 26.75540  -6.99945  50.59801  1.000 20.73756  ? 140 ARG A CZ  1 
ATOM   1111 N NH1 . ARG A 1 140 ? 27.33427  -7.97369  51.29350  1.000 18.67613  ? 140 ARG A NH1 1 
ATOM   1112 N NH2 . ARG A 1 140 ? 27.20036  -5.74578  50.71676  1.000 17.41569  ? 140 ARG A NH2 1 
ATOM   1113 N N   . ILE A 1 141 ? 22.58393  -8.60742  45.39163  1.000 18.28072  ? 141 ILE A N   1 
ATOM   1114 C CA  . ILE A 1 141 ? 22.75722  -9.61513  44.34807  1.000 20.56566  ? 141 ILE A CA  1 
ATOM   1115 C C   . ILE A 1 141 ? 24.20677  -10.06593 44.35565  1.000 20.14334  ? 141 ILE A C   1 
ATOM   1116 O O   . ILE A 1 141 ? 25.11345  -9.23188  44.27959  1.000 18.22777  ? 141 ILE A O   1 
ATOM   1117 C CB  . ILE A 1 141 ? 22.40998  -9.04427  42.96185  1.000 24.29403  ? 141 ILE A CB  1 
ATOM   1118 C CG1 . ILE A 1 141 ? 20.94562  -8.60116  42.93437  1.000 35.23863  ? 141 ILE A CG1 1 
ATOM   1119 C CG2 . ILE A 1 141 ? 22.69110  -10.07515 41.87194  1.000 37.29105  ? 141 ILE A CG2 1 
ATOM   1120 C CD1 . ILE A 1 141 ? 19.98068  -9.60851  43.42643  1.000 36.70419  ? 141 ILE A CD1 1 
ATOM   1121 N N   . ILE A 1 142 ? 24.43462  -11.37410 44.38141  1.000 23.52714  ? 142 ILE A N   1 
ATOM   1122 C CA  . ILE A 1 142 ? 25.78798  -11.92599 44.43150  1.000 22.90029  ? 142 ILE A CA  1 
ATOM   1123 C C   . ILE A 1 142 ? 25.94388  -12.86274 43.23688  1.000 27.66626  ? 142 ILE A C   1 
ATOM   1124 O O   . ILE A 1 142 ? 25.08427  -13.71324 42.99371  1.000 28.72637  ? 142 ILE A O   1 
ATOM   1125 C CB  . ILE A 1 142 ? 26.04979  -12.67734 45.75048  1.000 29.63927  ? 142 ILE A CB  1 
ATOM   1126 C CG1 . ILE A 1 142 ? 25.75275  -11.78345 46.94087  1.000 25.63791  ? 142 ILE A CG1 1 
ATOM   1127 C CG2 . ILE A 1 142 ? 27.49917  -13.22909 45.85117  1.000 27.94447  ? 142 ILE A CG2 1 
ATOM   1128 C CD1 . ILE A 1 142 ? 25.10097  -12.56226 48.10465  1.000 30.98565  ? 142 ILE A CD1 1 
ATOM   1129 N N   . SER A 1 143 ? 27.01869  -12.68725 42.48347  1.000 25.62356  ? 143 SER A N   1 
ATOM   1130 C CA  . SER A 1 143 ? 27.43513  -13.64488 41.46878  1.000 30.57899  ? 143 SER A CA  1 
ATOM   1131 C C   . SER A 1 143 ? 28.79972  -14.16907 41.92484  1.000 36.06801  ? 143 SER A C   1 
ATOM   1132 O O   . SER A 1 143 ? 29.77301  -13.41021 41.97037  1.000 30.84776  ? 143 SER A O   1 
ATOM   1133 C CB  . SER A 1 143 ? 27.48411  -12.97202 40.09868  1.000 31.22213  ? 143 SER A CB  1 
ATOM   1134 O OG  . SER A 1 143 ? 27.93707  -13.85082 39.06515  1.000 43.31412  ? 143 SER A OG  1 
ATOM   1135 N N   . THR A 1 144 ? 28.85576  -15.45745 42.34026  1.000 31.90726  ? 144 THR A N   1 
ATOM   1136 C CA  . THR A 1 144 ? 30.01188  -16.12865 42.92807  1.000 41.68415  ? 144 THR A CA  1 
ATOM   1137 C C   . THR A 1 144 ? 30.85286  -16.76491 41.83351  1.000 46.27283  ? 144 THR A C   1 
ATOM   1138 O O   . THR A 1 144 ? 30.32804  -17.09995 40.77378  1.000 45.04284  ? 144 THR A O   1 
ATOM   1139 C CB  . THR A 1 144 ? 29.56503  -17.22148 43.88141  1.000 51.54406  ? 144 THR A CB  1 
ATOM   1140 O OG1 . THR A 1 144 ? 29.00575  -18.29565 43.11049  1.000 61.97955  ? 144 THR A OG1 1 
ATOM   1141 C CG2 . THR A 1 144 ? 28.50941  -16.69229 44.86130  1.000 53.97270  ? 144 THR A CG2 1 
ATOM   1142 N N   . PRO A 1 145 ? 32.16727  -16.95862 42.05031  1.000 48.27151  ? 145 PRO A N   1 
ATOM   1143 C CA  . PRO A 1 145 ? 32.98480  -17.63075 41.02035  1.000 57.33650  ? 145 PRO A CA  1 
ATOM   1144 C C   . PRO A 1 145 ? 32.47779  -19.04231 40.75664  1.000 62.11829  ? 145 PRO A C   1 
ATOM   1145 O O   . PRO A 1 145 ? 32.71492  -19.96134 41.54861  1.000 64.44864  ? 145 PRO A O   1 
ATOM   1146 C CB  . PRO A 1 145 ? 34.40053  -17.63296 41.62238  1.000 46.46776  ? 145 PRO A CB  1 
ATOM   1147 C CG  . PRO A 1 145 ? 34.37743  -16.56139 42.69380  1.000 45.42068  ? 145 PRO A CG  1 
ATOM   1148 C CD  . PRO A 1 145 ? 32.96621  -16.59545 43.24100  1.000 50.59191  ? 145 PRO A CD  1 
ATOM   1149 N N   . ASP A 1 146 ? 31.76571  -19.22043 39.64898  1.000 68.20377  ? 146 ASP A N   1 
ATOM   1150 C CA  . ASP A 1 146 ? 30.95936  -20.41727 39.45213  1.000 68.38057  ? 146 ASP A CA  1 
ATOM   1151 C C   . ASP A 1 146 ? 30.76754  -20.73561 37.97710  1.000 73.42452  ? 146 ASP A C   1 
ATOM   1152 O O   . ASP A 1 146 ? 29.70297  -21.20092 37.57171  1.000 80.93824  ? 146 ASP A O   1 
ATOM   1153 C CB  . ASP A 1 146 ? 29.59811  -20.23467 40.11976  1.000 79.79812  ? 146 ASP A CB  1 
ATOM   1154 C CG  . ASP A 1 146 ? 29.20779  -21.41685 40.96718  1.000 89.09782  ? 146 ASP A CG  1 
ATOM   1155 O OD1 . ASP A 1 146 ? 30.03589  -21.83173 41.80576  1.000 84.50509  ? 146 ASP A OD1 1 
ATOM   1156 O OD2 . ASP A 1 146 ? 28.07722  -21.92399 40.79972  1.000 94.95464  ? 146 ASP A OD2 1 
ATOM   1157 N N   . PRO A 1 153 ? 18.39916  -14.22029 34.56233  1.000 72.71293  ? 153 PRO A N   1 
ATOM   1158 C CA  . PRO A 1 153 ? 17.80765  -12.88006 34.67622  1.000 74.50061  ? 153 PRO A CA  1 
ATOM   1159 C C   . PRO A 1 153 ? 16.29045  -12.93888 34.76572  1.000 75.57135  ? 153 PRO A C   1 
ATOM   1160 O O   . PRO A 1 153 ? 15.72111  -13.94467 34.34161  1.000 84.16278  ? 153 PRO A O   1 
ATOM   1161 C CB  . PRO A 1 153 ? 18.24530  -12.19200 33.38045  1.000 64.05538  ? 153 PRO A CB  1 
ATOM   1162 C CG  . PRO A 1 153 ? 18.41774  -13.29511 32.40643  1.000 59.29634  ? 153 PRO A CG  1 
ATOM   1163 C CD  . PRO A 1 153 ? 18.87332  -14.50130 33.19455  1.000 71.69532  ? 153 PRO A CD  1 
ATOM   1164 N N   . GLU A 1 154 ? 15.63920  -11.91003 35.30740  1.000 66.42611  ? 154 GLU A N   1 
ATOM   1165 C CA  . GLU A 1 154 ? 14.18724  -11.81683 35.20710  1.000 62.53032  ? 154 GLU A CA  1 
ATOM   1166 C C   . GLU A 1 154 ? 13.83240  -11.03823 33.94170  1.000 56.39577  ? 154 GLU A C   1 
ATOM   1167 O O   . GLU A 1 154 ? 14.53835  -10.09811 33.56204  1.000 55.11662  ? 154 GLU A O   1 
ATOM   1168 C CB  . GLU A 1 154 ? 13.58063  -11.15033 36.44655  1.000 58.24984  ? 154 GLU A CB  1 
ATOM   1169 C CG  . GLU A 1 154 ? 12.04465  -11.21300 36.48539  1.000 55.82313  ? 154 GLU A CG  1 
ATOM   1170 C CD  . GLU A 1 154 ? 11.44151  -10.60119 37.74882  1.000 53.65010  ? 154 GLU A CD  1 
ATOM   1171 O OE1 . GLU A 1 154 ? 12.20429  -10.22887 38.67093  1.000 54.49078  ? 154 GLU A OE1 1 
ATOM   1172 O OE2 . GLU A 1 154 ? 10.19507  -10.49158 37.81417  1.000 45.85613  ? 154 GLU A OE2 1 
ATOM   1173 N N   . GLY A 1 155 ? 12.75426  -11.45783 33.26302  1.000 37.47254  ? 155 GLY A N   1 
ATOM   1174 C CA  . GLY A 1 155 ? 12.35787  -10.81396 32.04557  1.000 34.81463  ? 155 GLY A CA  1 
ATOM   1175 C C   . GLY A 1 155 ? 11.77882  -9.43690  32.30834  1.000 24.60211  ? 155 GLY A C   1 
ATOM   1176 O O   . GLY A 1 155 ? 11.66477  -9.00060  33.45723  1.000 34.08234  ? 155 GLY A O   1 
ATOM   1177 N N   . PRO A 1 156 ? 11.43477  -8.72867  31.23579  1.000 26.25902  ? 156 PRO A N   1 
ATOM   1178 C CA  . PRO A 1 156 ? 10.74961  -7.43675  31.38797  1.000 22.18950  ? 156 PRO A CA  1 
ATOM   1179 C C   . PRO A 1 156 ? 9.49296   -7.60696  32.22493  1.000 25.29333  ? 156 PRO A C   1 
ATOM   1180 O O   . PRO A 1 156 ? 8.68937   -8.51173  31.98723  1.000 22.48110  ? 156 PRO A O   1 
ATOM   1181 C CB  . PRO A 1 156 ? 10.41674  -7.04484  29.94674  1.000 24.13067  ? 156 PRO A CB  1 
ATOM   1182 C CG  . PRO A 1 156 ? 11.43334  -7.75167  29.13282  1.000 28.12027  ? 156 PRO A CG  1 
ATOM   1183 C CD  . PRO A 1 156 ? 11.72890  -9.03712  29.82909  1.000 29.77037  ? 156 PRO A CD  1 
ATOM   1184 N N   . HIS A 1 157 ? 9.32038   -6.73881  33.21557  1.000 21.31471  ? 157 HIS A N   1 
ATOM   1185 C CA  . HIS A 1 157 ? 8.15667   -6.86116  34.09644  1.000 21.22246  ? 157 HIS A CA  1 
ATOM   1186 C C   . HIS A 1 157 ? 7.85003   -5.48915  34.67919  1.000 20.53983  ? 157 HIS A C   1 
ATOM   1187 O O   . HIS A 1 157 ? 8.57804   -4.52011  34.45101  1.000 19.91248  ? 157 HIS A O   1 
ATOM   1188 C CB  . HIS A 1 157 ? 8.43051   -7.85951  35.21569  1.000 22.32974  ? 157 HIS A CB  1 
ATOM   1189 C CG  . HIS A 1 157 ? 9.57270   -7.44455  36.08731  1.000 25.15412  ? 157 HIS A CG  1 
ATOM   1190 N ND1 . HIS A 1 157 ? 10.88839  -7.61907  35.70983  1.000 28.41187  ? 157 HIS A ND1 1 
ATOM   1191 C CD2 . HIS A 1 157 ? 9.60170   -6.77329  37.26502  1.000 23.24961  ? 157 HIS A CD2 1 
ATOM   1192 C CE1 . HIS A 1 157 ? 11.68100  -7.11986  36.63921  1.000 28.03721  ? 157 HIS A CE1 1 
ATOM   1193 N NE2 . HIS A 1 157 ? 10.92335  -6.59801  37.59233  1.000 28.78256  ? 157 HIS A NE2 1 
ATOM   1194 N N   . ARG A 1 158 ? 6.79329   -5.42729  35.47197  1.000 17.83849  ? 158 ARG A N   1 
ATOM   1195 C CA  . ARG A 1 158 ? 6.48435   -4.24394  36.25892  1.000 16.98250  ? 158 ARG A CA  1 
ATOM   1196 C C   . ARG A 1 158 ? 6.40197   -4.71538  37.69755  1.000 20.86651  ? 158 ARG A C   1 
ATOM   1197 O O   . ARG A 1 158 ? 6.30587   -5.91612  37.94626  1.000 19.81328  ? 158 ARG A O   1 
ATOM   1198 C CB  . ARG A 1 158 ? 5.18149   -3.55720  35.81070  1.000 17.72233  ? 158 ARG A CB  1 
ATOM   1199 C CG  . ARG A 1 158 ? 3.91731   -4.42165  36.04891  1.000 23.17225  ? 158 ARG A CG  1 
ATOM   1200 C CD  . ARG A 1 158 ? 2.61485   -3.63015  35.76724  1.000 18.73868  ? 158 ARG A CD  1 
ATOM   1201 N NE  . ARG A 1 158 ? 2.48827   -2.48056  36.66737  1.000 18.04698  ? 158 ARG A NE  1 
ATOM   1202 C CZ  . ARG A 1 158 ? 1.45398   -1.65085  36.66506  1.000 26.52477  ? 158 ARG A CZ  1 
ATOM   1203 N NH1 . ARG A 1 158 ? 0.39962   -1.86892  35.89030  1.000 19.90964  ? 158 ARG A NH1 1 
ATOM   1204 N NH2 . ARG A 1 158 ? 1.46987   -0.58406  37.46520  1.000 18.67632  ? 158 ARG A NH2 1 
ATOM   1205 N N   . ASP A 1 159 ? 6.54444   -3.78901  38.64979  1.000 20.16663  ? 159 ASP A N   1 
ATOM   1206 C CA  . ASP A 1 159 ? 6.46194   -4.11408  40.08138  1.000 17.57716  ? 159 ASP A CA  1 
ATOM   1207 C C   . ASP A 1 159 ? 5.03084   -4.09504  40.62724  1.000 21.16848  ? 159 ASP A C   1 
ATOM   1208 O O   . ASP A 1 159 ? 4.82956   -4.40982  41.80823  1.000 22.73324  ? 159 ASP A O   1 
ATOM   1209 C CB  . ASP A 1 159 ? 7.32668   -3.13618  40.89536  1.000 17.91947  ? 159 ASP A CB  1 
ATOM   1210 C CG  . ASP A 1 159 ? 8.81919   -3.40422  40.71228  1.000 21.90409  ? 159 ASP A CG  1 
ATOM   1211 O OD1 . ASP A 1 159 ? 9.17122   -4.31124  39.92798  1.000 17.77100  ? 159 ASP A OD1 1 
ATOM   1212 O OD2 . ASP A 1 159 ? 9.65309   -2.72774  41.35115  1.000 19.02938  ? 159 ASP A OD2 1 
ATOM   1213 N N   . GLU A 1 160 ? 4.04477   -3.73532  39.79681  1.000 21.10335  ? 160 GLU A N   1 
ATOM   1214 C CA  . GLU A 1 160 ? 2.63928   -3.59380  40.20029  1.000 18.72213  ? 160 GLU A CA  1 
ATOM   1215 C C   . GLU A 1 160 ? 2.48288   -2.54779  41.30765  1.000 23.41428  ? 160 GLU A C   1 
ATOM   1216 O O   . GLU A 1 160 ? 1.86441   -2.80348  42.34750  1.000 22.05075  ? 160 GLU A O   1 
ATOM   1217 C CB  . GLU A 1 160 ? 2.02915   -4.94756  40.62611  1.000 19.40786  ? 160 GLU A CB  1 
ATOM   1218 C CG  . GLU A 1 160 ? 2.10202   -6.05386  39.55270  1.000 24.08576  ? 160 GLU A CG  1 
ATOM   1219 C CD  . GLU A 1 160 ? 1.26132   -5.77744  38.31337  1.000 34.58169  ? 160 GLU A CD  1 
ATOM   1220 O OE1 . GLU A 1 160 ? 0.42820   -4.83914  38.34386  1.000 31.55138  ? 160 GLU A OE1 1 
ATOM   1221 O OE2 . GLU A 1 160 ? 1.43375   -6.50347  37.29531  1.000 37.50284  ? 160 GLU A OE2 1 
ATOM   1222 N N   . VAL A 1 161 ? 3.06568   -1.35740  41.07826  1.000 18.02613  ? 161 VAL A N   1 
ATOM   1223 C CA  . VAL A 1 161 ? 2.89181   -0.18894  41.93015  1.000 17.64885  ? 161 VAL A CA  1 
ATOM   1224 C C   . VAL A 1 161 ? 2.55374   0.97565   41.02131  1.000 17.62540  ? 161 VAL A C   1 
ATOM   1225 O O   . VAL A 1 161 ? 2.51010   0.81418   39.80964  1.000 18.81804  ? 161 VAL A O   1 
ATOM   1226 C CB  . VAL A 1 161 ? 4.14849   0.10849   42.78024  1.000 15.41377  ? 161 VAL A CB  1 
ATOM   1227 C CG1 . VAL A 1 161 ? 4.46900   -1.09628  43.71165  1.000 14.85714  ? 161 VAL A CG1 1 
ATOM   1228 C CG2 . VAL A 1 161 ? 5.37918   0.41225   41.85226  1.000 13.10074  ? 161 VAL A CG2 1 
ATOM   1229 N N   . ASP A 1 162 ? 2.34110   2.16953   41.60103  1.000 17.41734  ? 162 ASP A N   1 
ATOM   1230 C CA  . ASP A 1 162 ? 2.19491   3.36150   40.75008  1.000 16.90504  ? 162 ASP A CA  1 
ATOM   1231 C C   . ASP A 1 162 ? 3.53904   3.94646   40.32105  1.000 17.86705  ? 162 ASP A C   1 
ATOM   1232 O O   . ASP A 1 162 ? 3.72385   4.29990   39.14750  1.000 14.42299  ? 162 ASP A O   1 
ATOM   1233 C CB  . ASP A 1 162 ? 1.36679   4.41792   41.48612  1.000 15.79302  ? 162 ASP A CB  1 
ATOM   1234 C CG  . ASP A 1 162 ? -0.09247  3.99079   41.57682  1.000 22.32490  ? 162 ASP A CG  1 
ATOM   1235 O OD1 . ASP A 1 162 ? -0.60121  3.62682   40.51188  1.000 20.81985  ? 162 ASP A OD1 1 
ATOM   1236 O OD2 . ASP A 1 162 ? -0.68629  3.91932   42.66949  1.000 16.75123  ? 162 ASP A OD2 1 
ATOM   1237 N N   . PHE A 1 163 ? 4.47178   4.09595   41.26887  1.000 12.73437  ? 163 PHE A N   1 
ATOM   1238 C CA  . PHE A 1 163 ? 5.75921   4.71802   40.98595  1.000 14.29578  ? 163 PHE A CA  1 
ATOM   1239 C C   . PHE A 1 163 ? 6.85836   3.95610   41.73203  1.000 13.68924  ? 163 PHE A C   1 
ATOM   1240 O O   . PHE A 1 163 ? 6.63067   3.44217   42.83156  1.000 12.22802  ? 163 PHE A O   1 
ATOM   1241 C CB  . PHE A 1 163 ? 5.77318   6.18735   41.41252  1.000 15.22765  ? 163 PHE A CB  1 
ATOM   1242 C CG  . PHE A 1 163 ? 4.76972   7.03316   40.69099  1.000 14.56239  ? 163 PHE A CG  1 
ATOM   1243 C CD1 . PHE A 1 163 ? 4.95318   7.36546   39.34912  1.000 15.13083  ? 163 PHE A CD1 1 
ATOM   1244 C CD2 . PHE A 1 163 ? 3.62580   7.47631   41.35183  1.000 15.66644  ? 163 PHE A CD2 1 
ATOM   1245 C CE1 . PHE A 1 163 ? 3.98597   8.15891   38.64827  1.000 16.56528  ? 163 PHE A CE1 1 
ATOM   1246 C CE2 . PHE A 1 163 ? 2.67788   8.25652   40.65308  1.000 16.55680  ? 163 PHE A CE2 1 
ATOM   1247 C CZ  . PHE A 1 163 ? 2.88224   8.60316   39.32488  1.000 21.15023  ? 163 PHE A CZ  1 
ATOM   1248 N N   . GLY A 1 164 ? 8.05416   3.88297   41.12925  1.000 11.12607  ? 164 GLY A N   1 
ATOM   1249 C CA  . GLY A 1 164 ? 9.17403   3.23064   41.77138  1.000 13.36055  ? 164 GLY A CA  1 
ATOM   1250 C C   . GLY A 1 164 ? 10.39784  4.13661   41.81279  1.000 12.54977  ? 164 GLY A C   1 
ATOM   1251 O O   . GLY A 1 164 ? 10.54499  5.09141   41.02652  1.000 10.24233  ? 164 GLY A O   1 
ATOM   1252 N N   . VAL A 1 165 ? 11.31830  3.76605   42.69741  1.000 10.30189  ? 165 VAL A N   1 
ATOM   1253 C CA  . VAL A 1 165 ? 12.63664  4.39624   42.72506  1.000 12.95220  ? 165 VAL A CA  1 
ATOM   1254 C C   . VAL A 1 165 ? 13.66420  3.33524   43.09135  1.000 13.49104  ? 165 VAL A C   1 
ATOM   1255 O O   . VAL A 1 165 ? 13.38100  2.40649   43.85530  1.000 13.06574  ? 165 VAL A O   1 
ATOM   1256 C CB  . VAL A 1 165 ? 12.65884  5.61052   43.69568  1.000 12.36241  ? 165 VAL A CB  1 
ATOM   1257 C CG1 . VAL A 1 165 ? 12.31357  5.20431   45.10066  1.000 11.76690  ? 165 VAL A CG1 1 
ATOM   1258 C CG2 . VAL A 1 165 ? 13.97603  6.38243   43.65033  1.000 12.17072  ? 165 VAL A CG2 1 
ATOM   1259 N N   . ILE A 1 166 ? 14.85325  3.45416   42.50521  1.000 13.30621  ? 166 ILE A N   1 
ATOM   1260 C CA  . ILE A 1 166 ? 15.96234  2.59150   42.85633  1.000 11.58189  ? 166 ILE A CA  1 
ATOM   1261 C C   . ILE A 1 166 ? 17.19042  3.46646   43.13805  1.000 12.78279  ? 166 ILE A C   1 
ATOM   1262 O O   . ILE A 1 166 ? 17.48350  4.40244   42.39224  1.000 11.79862  ? 166 ILE A O   1 
ATOM   1263 C CB  . ILE A 1 166 ? 16.23235  1.53826   41.76607  1.000 11.86578  ? 166 ILE A CB  1 
ATOM   1264 C CG1 . ILE A 1 166 ? 17.50469  0.73870   42.08838  1.000 13.17534  ? 166 ILE A CG1 1 
ATOM   1265 C CG2 . ILE A 1 166 ? 16.44493  2.21522   40.39190  1.000 12.80593  ? 166 ILE A CG2 1 
ATOM   1266 C CD1 . ILE A 1 166 ? 17.63796  -0.52929  41.23151  1.000 16.10680  ? 166 ILE A CD1 1 
ATOM   1267 N N   . HIS A 1 167 ? 17.89680  3.16760   44.22420  1.000 10.58843  ? 167 HIS A N   1 
ATOM   1268 C CA  . HIS A 1 167 ? 19.15016  3.83991   44.56690  1.000 9.23430   ? 167 HIS A CA  1 
ATOM   1269 C C   . HIS A 1 167 ? 20.25919  2.78222   44.63371  1.000 16.02433  ? 167 HIS A C   1 
ATOM   1270 O O   . HIS A 1 167 ? 20.07976  1.75413   45.30289  1.000 13.32702  ? 167 HIS A O   1 
ATOM   1271 C CB  . HIS A 1 167 ? 19.01693  4.50829   45.95745  1.000 11.23759  ? 167 HIS A CB  1 
ATOM   1272 C CG  . HIS A 1 167 ? 17.87869  5.49524   46.09452  1.000 15.19674  ? 167 HIS A CG  1 
ATOM   1273 N ND1 . HIS A 1 167 ? 17.87520  6.72420   45.46566  1.000 15.26370  ? 167 HIS A ND1 1 
ATOM   1274 C CD2 . HIS A 1 167 ? 16.76740  5.47196   46.87297  1.000 16.66234  ? 167 HIS A CD2 1 
ATOM   1275 C CE1 . HIS A 1 167 ? 16.80133  7.41151   45.83463  1.000 15.64270  ? 167 HIS A CE1 1 
ATOM   1276 N NE2 . HIS A 1 167 ? 16.11258  6.67455   46.69921  1.000 12.43517  ? 167 HIS A NE2 1 
ATOM   1277 N N   . LEU A 1 168 ? 21.41293  3.03509   44.00162  1.000 9.99426   ? 168 LEU A N   1 
ATOM   1278 C CA  . LEU A 1 168 ? 22.52328  2.07796   44.10012  1.000 10.69269  ? 168 LEU A CA  1 
ATOM   1279 C C   . LEU A 1 168 ? 23.21076  2.32649   45.43998  1.000 13.50591  ? 168 LEU A C   1 
ATOM   1280 O O   . LEU A 1 168 ? 23.64164  3.44044   45.70645  1.000 15.92226  ? 168 LEU A O   1 
ATOM   1281 C CB  . LEU A 1 168 ? 23.49605  2.24948   42.93940  1.000 12.18193  ? 168 LEU A CB  1 
ATOM   1282 C CG  . LEU A 1 168 ? 24.71491  1.30596   43.01133  1.000 16.98237  ? 168 LEU A CG  1 
ATOM   1283 C CD1 . LEU A 1 168 ? 24.32933  -0.14564  42.65751  1.000 14.72812  ? 168 LEU A CD1 1 
ATOM   1284 C CD2 . LEU A 1 168 ? 25.75925  1.84041   42.03739  1.000 17.54634  ? 168 LEU A CD2 1 
ATOM   1285 N N   . MET A 1 169 ? 23.23346  1.33250   46.31972  1.000 14.47808  ? 169 MET A N   1 
ATOM   1286 C CA  . MET A 1 169 ? 23.99968  1.50275   47.56067  1.000 12.55661  ? 169 MET A CA  1 
ATOM   1287 C C   . MET A 1 169 ? 25.45493  1.14768   47.37720  1.000 19.42411  ? 169 MET A C   1 
ATOM   1288 O O   . MET A 1 169 ? 26.31660  1.67817   48.09959  1.000 19.74278  ? 169 MET A O   1 
ATOM   1289 C CB  . MET A 1 169 ? 23.41756  0.61543   48.68482  1.000 13.89851  ? 169 MET A CB  1 
ATOM   1290 C CG  . MET A 1 169 ? 21.99877  1.06738   49.08556  1.000 15.41864  ? 169 MET A CG  1 
ATOM   1291 S SD  . MET A 1 169 ? 22.15641  2.72263   49.88848  1.000 30.11725  ? 169 MET A SD  1 
ATOM   1292 C CE  . MET A 1 169 ? 21.16434  3.55889   48.80866  1.000 16.13236  ? 169 MET A CE  1 
ATOM   1293 N N   . GLY A 1 170 ? 25.74229  0.22916   46.47101  1.000 18.18857  ? 170 GLY A N   1 
ATOM   1294 C CA  . GLY A 1 170 ? 27.09601  -0.27840  46.35288  1.000 22.70326  ? 170 GLY A CA  1 
ATOM   1295 C C   . GLY A 1 170 ? 27.26808  -1.27858  45.22936  1.000 17.88971  ? 170 GLY A C   1 
ATOM   1296 O O   . GLY A 1 170 ? 26.33337  -1.99285  44.87515  1.000 16.71626  ? 170 GLY A O   1 
ATOM   1297 N N   . ARG A 1 171 ? 28.48176  -1.33667  44.68179  1.000 15.73564  ? 171 ARG A N   1 
ATOM   1298 C CA  . ARG A 1 171 ? 28.82941  -2.21821  43.57033  1.000 19.80365  ? 171 ARG A CA  1 
ATOM   1299 C C   . ARG A 1 171 ? 30.27008  -2.66785  43.81717  1.000 23.04878  ? 171 ARG A C   1 
ATOM   1300 O O   . ARG A 1 171 ? 31.13131  -1.81129  44.00896  1.000 21.55295  ? 171 ARG A O   1 
ATOM   1301 C CB  . ARG A 1 171 ? 28.70120  -1.43983  42.24493  1.000 27.39155  ? 171 ARG A CB  1 
ATOM   1302 C CG  . ARG A 1 171 ? 28.24825  -2.19934  41.05114  1.000 43.60601  ? 171 ARG A CG  1 
ATOM   1303 C CD  . ARG A 1 171 ? 28.03976  -1.24098  39.86511  1.000 28.99426  ? 171 ARG A CD  1 
ATOM   1304 N NE  . ARG A 1 171 ? 28.02074  -1.96437  38.59951  1.000 36.33946  ? 171 ARG A NE  1 
ATOM   1305 C CZ  . ARG A 1 171 ? 28.94723  -1.83566  37.66031  1.000 37.02000  ? 171 ARG A CZ  1 
ATOM   1306 N NH1 . ARG A 1 171 ? 29.99079  -1.03694  37.82601  1.000 38.80379  ? 171 ARG A NH1 1 
ATOM   1307 N NH2 . ARG A 1 171 ? 28.81553  -2.51247  36.52204  1.000 38.89754  ? 171 ARG A NH2 1 
ATOM   1308 N N   . PHE A 1 172 ? 30.53381  -3.97940  43.86439  1.000 19.29143  ? 172 PHE A N   1 
ATOM   1309 C CA  . PHE A 1 172 ? 31.85181  -4.49473  44.24618  1.000 21.09677  ? 172 PHE A CA  1 
ATOM   1310 C C   . PHE A 1 172 ? 32.31971  -5.53829  43.23904  1.000 19.44575  ? 172 PHE A C   1 
ATOM   1311 O O   . PHE A 1 172 ? 31.65468  -6.55134  43.05314  1.000 17.19276  ? 172 PHE A O   1 
ATOM   1312 C CB  . PHE A 1 172 ? 31.79906  -5.10433  45.64664  1.000 22.85639  ? 172 PHE A CB  1 
ATOM   1313 C CG  . PHE A 1 172 ? 31.19653  -4.15538  46.70163  1.000 28.49551  ? 172 PHE A CG  1 
ATOM   1314 C CD1 . PHE A 1 172 ? 31.99058  -3.17282  47.30883  1.000 29.85267  ? 172 PHE A CD1 1 
ATOM   1315 C CD2 . PHE A 1 172 ? 29.85086  -4.23631  47.05883  1.000 25.52502  ? 172 PHE A CD2 1 
ATOM   1316 C CE1 . PHE A 1 172 ? 31.46348  -2.29596  48.25661  1.000 31.10174  ? 172 PHE A CE1 1 
ATOM   1317 C CE2 . PHE A 1 172 ? 29.31009  -3.36761  48.03838  1.000 22.18027  ? 172 PHE A CE2 1 
ATOM   1318 C CZ  . PHE A 1 172 ? 30.12642  -2.37780  48.61702  1.000 26.27332  ? 172 PHE A CZ  1 
ATOM   1319 N N   . ASN A 1 173 ? 33.46894  -5.30049  42.60436  1.000 22.35582  ? 173 ASN A N   1 
ATOM   1320 C CA  . ASN A 1 173 ? 34.03483  -6.27421  41.68645  1.000 18.82885  ? 173 ASN A CA  1 
ATOM   1321 C C   . ASN A 1 173 ? 33.03495  -6.67820  40.60966  1.000 21.30229  ? 173 ASN A C   1 
ATOM   1322 O O   . ASN A 1 173 ? 33.01643  -7.82392  40.17035  1.000 15.49181  ? 173 ASN A O   1 
ATOM   1323 C CB  . ASN A 1 173 ? 34.53239  -7.52935  42.44822  1.000 17.91431  ? 173 ASN A CB  1 
ATOM   1324 C CG  . ASN A 1 173 ? 35.31804  -8.48950  41.53306  1.000 21.21390  ? 173 ASN A CG  1 
ATOM   1325 O OD1 . ASN A 1 173 ? 36.05794  -8.03118  40.66071  1.000 21.94567  ? 173 ASN A OD1 1 
ATOM   1326 N ND2 . ASN A 1 173 ? 35.05682  -9.79525  41.64996  1.000 22.58722  ? 173 ASN A ND2 1 
ATOM   1327 N N   . ALA A 1 174 ? 32.19942  -5.72949  40.15344  1.000 21.11651  ? 174 ALA A N   1 
ATOM   1328 C CA  . ALA A 1 174 ? 31.04442  -6.07510  39.32680  1.000 20.26372  ? 174 ALA A CA  1 
ATOM   1329 C C   . ALA A 1 174 ? 31.08729  -5.35141  37.98127  1.000 25.16583  ? 174 ALA A C   1 
ATOM   1330 O O   . ALA A 1 174 ? 31.29362  -4.13424  37.92675  1.000 25.50944  ? 174 ALA A O   1 
ATOM   1331 C CB  . ALA A 1 174 ? 29.72607  -5.74680  40.06057  1.000 20.08247  ? 174 ALA A CB  1 
ATOM   1332 N N   . ALA A 1 175 ? 30.89699  -6.11107  36.90652  1.000 24.92279  ? 175 ALA A N   1 
ATOM   1333 C CA  . ALA A 1 175 ? 30.52787  -5.59767  35.59352  1.000 27.96938  ? 175 ALA A CA  1 
ATOM   1334 C C   . ALA A 1 175 ? 29.11650  -6.08889  35.24552  1.000 26.00128  ? 175 ALA A C   1 
ATOM   1335 O O   . ALA A 1 175 ? 28.53832  -6.91871  35.94832  1.000 21.68646  ? 175 ALA A O   1 
ATOM   1336 C CB  . ALA A 1 175 ? 31.54085  -6.04801  34.53707  1.000 30.66159  ? 175 ALA A CB  1 
ATOM   1337 N N   . GLY A 1 176 ? 28.56767  -5.59861  34.12772  1.000 25.71804  ? 176 GLY A N   1 
ATOM   1338 C CA  . GLY A 1 176 ? 27.17347  -5.93923  33.83015  1.000 23.20356  ? 176 GLY A CA  1 
ATOM   1339 C C   . GLY A 1 176 ? 26.22710  -5.15295  34.74247  1.000 19.57002  ? 176 GLY A C   1 
ATOM   1340 O O   . GLY A 1 176 ? 26.53684  -4.06234  35.23753  1.000 21.11181  ? 176 GLY A O   1 
ATOM   1341 N N   . GLY A 1 177 ? 25.06367  -5.73491  34.98996  1.000 18.37487  ? 177 GLY A N   1 
ATOM   1342 C CA  . GLY A 1 177 ? 24.08280  -5.05812  35.80960  1.000 17.74130  ? 177 GLY A CA  1 
ATOM   1343 C C   . GLY A 1 177 ? 23.49313  -3.81709  35.18286  1.000 16.94478  ? 177 GLY A C   1 
ATOM   1344 O O   . GLY A 1 177 ? 23.02804  -2.94253  35.91605  1.000 17.66792  ? 177 GLY A O   1 
ATOM   1345 N N   . GLU A 1 178 ? 23.51733  -3.70140  33.85743  1.000 16.03966  ? 178 GLU A N   1 
ATOM   1346 C CA  . GLU A 1 178 ? 22.81455  -2.59579  33.19721  1.000 19.86159  ? 178 GLU A CA  1 
ATOM   1347 C C   . GLU A 1 178 ? 21.29313  -2.69883  33.38213  1.000 18.34163  ? 178 GLU A C   1 
ATOM   1348 O O   . GLU A 1 178 ? 20.69886  -3.78146  33.23991  1.000 19.52658  ? 178 GLU A O   1 
ATOM   1349 C CB  . GLU A 1 178 ? 23.11761  -2.58814  31.69043  1.000 18.36344  ? 178 GLU A CB  1 
ATOM   1350 C CG  . GLU A 1 178 ? 24.62622  -2.38078  31.38154  1.000 25.65793  ? 178 GLU A CG  1 
ATOM   1351 C CD  . GLU A 1 178 ? 25.45998  -3.68573  31.24708  1.000 25.16168  ? 178 GLU A CD  1 
ATOM   1352 O OE1 . GLU A 1 178 ? 25.01360  -4.78348  31.65731  1.000 20.86418  ? 178 GLU A OE1 1 
ATOM   1353 O OE2 . GLU A 1 178 ? 26.60177  -3.59835  30.72796  1.000 24.94455  ? 178 GLU A OE2 1 
ATOM   1354 N N   . SER A 1 179 ? 20.66603  -1.56158  33.67888  1.000 15.46692  ? 179 SER A N   1 
ATOM   1355 C CA  . SER A 1 179 ? 19.20888  -1.47294  33.77033  1.000 16.61829  ? 179 SER A CA  1 
ATOM   1356 C C   . SER A 1 179 ? 18.59867  -1.27057  32.39813  1.000 17.74830  ? 179 SER A C   1 
ATOM   1357 O O   . SER A 1 179 ? 19.11649  -0.48853  31.59326  1.000 18.80856  ? 179 SER A O   1 
ATOM   1358 C CB  . SER A 1 179 ? 18.82306  -0.30338  34.67425  1.000 16.77313  ? 179 SER A CB  1 
ATOM   1359 O OG  . SER A 1 179 ? 19.43210  -0.50706  35.92096  1.000 19.77449  ? 179 SER A OG  1 
ATOM   1360 N N   . GLN A 1 180 ? 17.45737  -1.89926  32.15862  1.000 17.75552  ? 180 GLN A N   1 
ATOM   1361 C CA  . GLN A 1 180 ? 16.78170  -1.79088  30.86962  1.000 19.50831  ? 180 GLN A CA  1 
ATOM   1362 C C   . GLN A 1 180 ? 15.34815  -1.32561  31.04123  1.000 18.12899  ? 180 GLN A C   1 
ATOM   1363 O O   . GLN A 1 180 ? 14.63900  -1.79023  31.94747  1.000 17.51875  ? 180 GLN A O   1 
ATOM   1364 C CB  . GLN A 1 180 ? 16.78448  -3.13125  30.16708  1.000 21.02550  ? 180 GLN A CB  1 
ATOM   1365 C CG  . GLN A 1 180 ? 18.18261  -3.69657  30.08602  1.000 22.42762  ? 180 GLN A CG  1 
ATOM   1366 C CD  . GLN A 1 180 ? 18.25484  -4.81706  29.13107  1.000 33.59688  ? 180 GLN A CD  1 
ATOM   1367 O OE1 . GLN A 1 180 ? 17.45123  -5.73266  29.20009  1.000 30.96173  ? 180 GLN A OE1 1 
ATOM   1368 N NE2 . GLN A 1 180 ? 19.20165  -4.75621  28.21333  1.000 36.67276  ? 180 GLN A NE2 1 
ATOM   1369 N N   . VAL A 1 181 ? 14.91918  -0.44887  30.13245  1.000 18.63083  ? 181 VAL A N   1 
ATOM   1370 C CA  . VAL A 1 181 ? 13.56040  0.08394   30.10685  1.000 15.12586  ? 181 VAL A CA  1 
ATOM   1371 C C   . VAL A 1 181 ? 12.90999  -0.41747  28.82684  1.000 22.88225  ? 181 VAL A C   1 
ATOM   1372 O O   . VAL A 1 181 ? 13.49396  -0.27729  27.73883  1.000 18.77122  ? 181 VAL A O   1 
ATOM   1373 C CB  . VAL A 1 181 ? 13.55216  1.62279   30.14347  1.000 20.86858  ? 181 VAL A CB  1 
ATOM   1374 C CG1 . VAL A 1 181 ? 12.07975  2.19011   30.06080  1.000 18.81193  ? 181 VAL A CG1 1 
ATOM   1375 C CG2 . VAL A 1 181 ? 14.28655  2.16201   31.37521  1.000 17.29541  ? 181 VAL A CG2 1 
ATOM   1376 N N   . TYR A 1 182 ? 11.71701  -1.00268  28.94987  1.000 17.22283  ? 182 TYR A N   1 
ATOM   1377 C CA  . TYR A 1 182 ? 10.97927  -1.54460  27.81160  1.000 17.10924  ? 182 TYR A CA  1 
ATOM   1378 C C   . TYR A 1 182 ? 9.66788   -0.79944  27.64921  1.000 21.71949  ? 182 TYR A C   1 
ATOM   1379 O O   . TYR A 1 182 ? 9.03822   -0.40038  28.64137  1.000 19.64864  ? 182 TYR A O   1 
ATOM   1380 C CB  . TYR A 1 182 ? 10.65297  -3.03027  28.00424  1.000 18.86046  ? 182 TYR A CB  1 
ATOM   1381 C CG  . TYR A 1 182 ? 11.86491  -3.93504  27.92927  1.000 23.69917  ? 182 TYR A CG  1 
ATOM   1382 C CD1 . TYR A 1 182 ? 12.69694  -4.10989  29.02419  1.000 23.45665  ? 182 TYR A CD1 1 
ATOM   1383 C CD2 . TYR A 1 182 ? 12.18352  -4.58843  26.73756  1.000 24.03156  ? 182 TYR A CD2 1 
ATOM   1384 C CE1 . TYR A 1 182 ? 13.82358  -4.93966  28.95107  1.000 23.61322  ? 182 TYR A CE1 1 
ATOM   1385 C CE2 . TYR A 1 182 ? 13.31147  -5.39791  26.64172  1.000 26.43238  ? 182 TYR A CE2 1 
ATOM   1386 C CZ  . TYR A 1 182 ? 14.11605  -5.56870  27.76425  1.000 28.58208  ? 182 TYR A CZ  1 
ATOM   1387 O OH  . TYR A 1 182 ? 15.21892  -6.37218  27.70087  1.000 32.60949  ? 182 TYR A OH  1 
ATOM   1388 N N   . SER A 1 183 ? 9.22423   -0.65829  26.40390  1.000 24.35175  ? 183 SER A N   1 
ATOM   1389 C CA  . SER A 1 183 ? 7.84562   -0.23753  26.17942  1.000 26.03057  ? 183 SER A CA  1 
ATOM   1390 C C   . SER A 1 183 ? 6.90595   -1.31786  26.67669  1.000 18.66329  ? 183 SER A C   1 
ATOM   1391 O O   . SER A 1 183 ? 7.29500   -2.45635  26.91933  1.000 19.80250  ? 183 SER A O   1 
ATOM   1392 C CB  . SER A 1 183 ? 7.54622   -0.00609  24.69410  1.000 30.03151  ? 183 SER A CB  1 
ATOM   1393 O OG  . SER A 1 183 ? 7.59504   -1.27365  24.04402  1.000 28.41571  ? 183 SER A OG  1 
ATOM   1394 N N   . LEU A 1 184 ? 5.62855   -0.95004  26.78086  1.000 24.98077  ? 184 LEU A N   1 
ATOM   1395 C CA  . LEU A 1 184 ? 4.61392   -1.93678  27.12190  1.000 28.25835  ? 184 LEU A CA  1 
ATOM   1396 C C   . LEU A 1 184 ? 4.46468   -2.99209  26.03284  1.000 32.87530  ? 184 LEU A C   1 
ATOM   1397 O O   . LEU A 1 184 ? 3.97704   -4.08607  26.31804  1.000 31.54835  ? 184 LEU A O   1 
ATOM   1398 C CB  . LEU A 1 184 ? 3.27670   -1.25718  27.37843  1.000 28.01422  ? 184 LEU A CB  1 
ATOM   1399 C CG  . LEU A 1 184 ? 3.18043   -0.33793  28.61182  1.000 29.10217  ? 184 LEU A CG  1 
ATOM   1400 C CD1 . LEU A 1 184 ? 1.74377   0.07597   28.83638  1.000 33.98007  ? 184 LEU A CD1 1 
ATOM   1401 C CD2 . LEU A 1 184 ? 3.71865   -1.01195  29.88285  1.000 23.06353  ? 184 LEU A CD2 1 
ATOM   1402 N N   . GLU A 1 185 ? 4.90171   -2.70592  24.80419  1.000 29.50080  ? 185 GLU A N   1 
ATOM   1403 C CA  . GLU A 1 185 ? 4.97197   -3.75454  23.78663  1.000 36.01288  ? 185 GLU A CA  1 
ATOM   1404 C C   . GLU A 1 185 ? 6.26455   -4.55164  23.86266  1.000 38.87490  ? 185 GLU A C   1 
ATOM   1405 O O   . GLU A 1 185 ? 6.58045   -5.26646  22.90932  1.000 34.55309  ? 185 GLU A O   1 
ATOM   1406 C CB  . GLU A 1 185 ? 4.82175   -3.16414  22.37536  1.000 35.37782  ? 185 GLU A CB  1 
ATOM   1407 C CG  . GLU A 1 185 ? 3.64168   -2.20210  22.20389  1.000 42.41180  ? 185 GLU A CG  1 
ATOM   1408 C CD  . GLU A 1 185 ? 4.09112   -0.74159  22.09838  1.000 61.52108  ? 185 GLU A CD  1 
ATOM   1409 O OE1 . GLU A 1 185 ? 4.51619   -0.32603  20.99407  1.000 75.14984  ? 185 GLU A OE1 1 
ATOM   1410 O OE2 . GLU A 1 185 ? 4.03428   -0.01088  23.11899  1.000 51.87965  ? 185 GLU A OE2 1 
ATOM   1411 N N   . ARG A 1 186 ? 7.02627   -4.42465  24.95320  1.000 27.56052  ? 186 ARG A N   1 
ATOM   1412 C CA  . ARG A 1 186 ? 8.22658   -5.22950  25.21380  1.000 31.71234  ? 186 ARG A CA  1 
ATOM   1413 C C   . ARG A 1 186 ? 9.37032   -4.95868  24.23655  1.000 29.69249  ? 186 ARG A C   1 
ATOM   1414 O O   . ARG A 1 186 ? 10.20563  -5.83100  24.00030  1.000 30.80017  ? 186 ARG A O   1 
ATOM   1415 C CB  . ARG A 1 186 ? 7.91836   -6.72454  25.24470  1.000 38.87761  ? 186 ARG A CB  1 
ATOM   1416 C CG  . ARG A 1 186 ? 7.04185   -7.08585  26.38788  1.000 45.81746  ? 186 ARG A CG  1 
ATOM   1417 C CD  . ARG A 1 186 ? 6.73689   -8.56561  26.44025  1.000 47.67476  ? 186 ARG A CD  1 
ATOM   1418 N NE  . ARG A 1 186 ? 6.35686   -8.92025  27.79945  1.000 50.92394  ? 186 ARG A NE  1 
ATOM   1419 C CZ  . ARG A 1 186 ? 7.13968   -9.57610  28.64424  1.000 58.51233  ? 186 ARG A CZ  1 
ATOM   1420 N NH1 . ARG A 1 186 ? 8.32946   -10.03280 28.27541  1.000 56.99747  ? 186 ARG A NH1 1 
ATOM   1421 N NH2 . ARG A 1 186 ? 6.71454   -9.79116  29.88630  1.000 78.69601  ? 186 ARG A NH2 1 
ATOM   1422 N N   . GLU A 1 187 ? 9.45427   -3.75932  23.68563  1.000 29.66442  ? 187 GLU A N   1 
ATOM   1423 C CA  . GLU A 1 187 ? 10.61933  -3.34898  22.92018  1.000 35.11393  ? 187 GLU A CA  1 
ATOM   1424 C C   . GLU A 1 187 ? 11.54651  -2.55024  23.82640  1.000 33.08281  ? 187 GLU A C   1 
ATOM   1425 O O   . GLU A 1 187 ? 11.08752  -1.66496  24.56527  1.000 25.10071  ? 187 GLU A O   1 
ATOM   1426 C CB  . GLU A 1 187 ? 10.23189  -2.50505  21.71087  1.000 37.79978  ? 187 GLU A CB  1 
ATOM   1427 C CG  . GLU A 1 187 ? 9.27366   -3.20062  20.74880  1.000 54.34420  ? 187 GLU A CG  1 
ATOM   1428 C CD  . GLU A 1 187 ? 9.87421   -4.44813  20.07777  1.000 75.66601  ? 187 GLU A CD  1 
ATOM   1429 O OE1 . GLU A 1 187 ? 11.11819  -4.62844  20.09604  1.000 67.92081  ? 187 GLU A OE1 1 
ATOM   1430 O OE2 . GLU A 1 187 ? 9.08977   -5.25466  19.52234  1.000 79.66404  ? 187 GLU A OE2 1 
ATOM   1431 N N   . LEU A 1 188 ? 12.84354  -2.85871  23.74900  1.000 29.68675  ? 188 LEU A N   1 
ATOM   1432 C CA  . LEU A 1 188 ? 13.86073  -2.14442  24.50559  1.000 30.40540  ? 188 LEU A CA  1 
ATOM   1433 C C   . LEU A 1 188 ? 13.94655  -0.70690  24.02647  1.000 30.95542  ? 188 LEU A C   1 
ATOM   1434 O O   . LEU A 1 188 ? 14.27675  -0.45106  22.86515  1.000 32.43656  ? 188 LEU A O   1 
ATOM   1435 C CB  . LEU A 1 188 ? 15.21545  -2.83828  24.34548  1.000 32.23641  ? 188 LEU A CB  1 
ATOM   1436 C CG  . LEU A 1 188 ? 16.32700  -2.31637  25.26402  1.000 27.50606  ? 188 LEU A CG  1 
ATOM   1437 C CD1 . LEU A 1 188 ? 16.03868  -2.66253  26.72288  1.000 26.87448  ? 188 LEU A CD1 1 
ATOM   1438 C CD2 . LEU A 1 188 ? 17.67399  -2.89415  24.86909  1.000 31.39183  ? 188 LEU A CD2 1 
ATOM   1439 N N   . VAL A 1 189 ? 13.69482  0.24938   24.91421  1.000 24.05274  ? 189 VAL A N   1 
ATOM   1440 C CA  . VAL A 1 189 ? 13.76886  1.63653   24.51710  1.000 19.84957  ? 189 VAL A CA  1 
ATOM   1441 C C   . VAL A 1 189 ? 14.96955  2.34536   25.11221  1.000 23.93114  ? 189 VAL A C   1 
ATOM   1442 O O   . VAL A 1 189 ? 15.48571  3.27846   24.48551  1.000 22.61920  ? 189 VAL A O   1 
ATOM   1443 C CB  . VAL A 1 189 ? 12.46423  2.41246   24.83258  1.000 31.70156  ? 189 VAL A CB  1 
ATOM   1444 C CG1 . VAL A 1 189 ? 11.27328  1.74260   24.13069  1.000 31.77068  ? 189 VAL A CG1 1 
ATOM   1445 C CG2 . VAL A 1 189 ? 12.23238  2.58033   26.33623  1.000 25.13635  ? 189 VAL A CG2 1 
ATOM   1446 N N   . ALA A 1 190 ? 15.43394  1.94107   26.30149  1.000 21.83089  ? 190 ALA A N   1 
ATOM   1447 C CA  . ALA A 1 190 ? 16.57786  2.61061   26.91010  1.000 17.72123  ? 190 ALA A CA  1 
ATOM   1448 C C   . ALA A 1 190 ? 17.33920  1.60680   27.77113  1.000 22.63064  ? 190 ALA A C   1 
ATOM   1449 O O   . ALA A 1 190 ? 16.76657  0.62709   28.23791  1.000 16.80767  ? 190 ALA A O   1 
ATOM   1450 C CB  . ALA A 1 190 ? 16.12650  3.81160   27.75540  1.000 18.87007  ? 190 ALA A CB  1 
ATOM   1451 N N   . GLU A 1 191 ? 18.64678  1.84457   27.95252  1.000 18.64546  ? 191 GLU A N   1 
ATOM   1452 C CA  . GLU A 1 191 ? 19.46703  1.07808   28.87581  1.000 16.20565  ? 191 GLU A CA  1 
ATOM   1453 C C   . GLU A 1 191 ? 20.43316  2.02375   29.57924  1.000 17.92094  ? 191 GLU A C   1 
ATOM   1454 O O   . GLU A 1 191 ? 21.00091  2.90608   28.93259  1.000 17.70484  ? 191 GLU A O   1 
ATOM   1455 C CB  . GLU A 1 191 ? 20.26211  0.01445   28.09559  1.000 19.70080  ? 191 GLU A CB  1 
ATOM   1456 C CG  . GLU A 1 191 ? 21.22861  -0.78794  28.98662  1.000 22.48950  ? 191 GLU A CG  1 
ATOM   1457 C CD  . GLU A 1 191 ? 21.98170  -1.81631  28.15649  1.000 41.20601  ? 191 GLU A CD  1 
ATOM   1458 O OE1 . GLU A 1 191 ? 21.40179  -2.89459  27.90847  1.000 30.37004  ? 191 GLU A OE1 1 
ATOM   1459 O OE2 . GLU A 1 191 ? 23.12565  -1.51647  27.71914  1.000 32.33215  ? 191 GLU A OE2 1 
ATOM   1460 N N   . PHE A 1 192 ? 20.62970  1.87082   30.88735  1.000 15.12735  ? 192 PHE A N   1 
ATOM   1461 C CA  . PHE A 1 192 ? 21.55202  2.76490   31.58202  1.000 13.77705  ? 192 PHE A CA  1 
ATOM   1462 C C   . PHE A 1 192 ? 22.28139  1.92676   32.62016  1.000 17.95074  ? 192 PHE A C   1 
ATOM   1463 O O   . PHE A 1 192 ? 22.02089  0.72501   32.74831  1.000 15.87093  ? 192 PHE A O   1 
ATOM   1464 C CB  . PHE A 1 192 ? 20.80279  3.94676   32.19318  1.000 14.22224  ? 192 PHE A CB  1 
ATOM   1465 C CG  . PHE A 1 192 ? 19.75673  3.53030   33.20321  1.000 18.08292  ? 192 PHE A CG  1 
ATOM   1466 C CD1 . PHE A 1 192 ? 18.47292  3.22095   32.79441  1.000 19.98929  ? 192 PHE A CD1 1 
ATOM   1467 C CD2 . PHE A 1 192 ? 20.05238  3.44872   34.53653  1.000 15.65252  ? 192 PHE A CD2 1 
ATOM   1468 C CE1 . PHE A 1 192 ? 17.50768  2.82223   33.68693  1.000 19.33407  ? 192 PHE A CE1 1 
ATOM   1469 C CE2 . PHE A 1 192 ? 19.07317  3.04970   35.44460  1.000 14.69598  ? 192 PHE A CE2 1 
ATOM   1470 C CZ  . PHE A 1 192 ? 17.79350  2.76082   35.00351  1.000 15.34842  ? 192 PHE A CZ  1 
ATOM   1471 N N   A CYS A 1 193 ? 23.24408  2.50495   33.33643  0.535 14.54218  ? 193 CYS A N   1 
ATOM   1472 N N   B CYS A 1 193 ? 23.17391  2.59046   33.36816  0.465 14.63605  ? 193 CYS A N   1 
ATOM   1473 C CA  A CYS A 1 193 ? 23.95346  1.70464   34.33164  0.535 16.19777  ? 193 CYS A CA  1 
ATOM   1474 C CA  B CYS A 1 193 ? 24.09801  1.93812   34.29481  0.465 16.96302  ? 193 CYS A CA  1 
ATOM   1475 C C   A CYS A 1 193 ? 24.19813  2.56113   35.55818  0.535 17.38964  ? 193 CYS A C   1 
ATOM   1476 C C   B CYS A 1 193 ? 24.12087  2.72580   35.59291  0.465 17.46390  ? 193 CYS A C   1 
ATOM   1477 O O   A CYS A 1 193 ? 24.87879  3.58929   35.48468  0.535 18.18447  ? 193 CYS A O   1 
ATOM   1478 O O   B CYS A 1 193 ? 24.63017  3.85096   35.62546  0.465 18.40904  ? 193 CYS A O   1 
ATOM   1479 C CB  A CYS A 1 193 ? 25.27697  1.11755   33.80796  0.535 19.89922  ? 193 CYS A CB  1 
ATOM   1480 C CB  B CYS A 1 193 ? 25.51457  1.86621   33.71807  0.465 18.93836  ? 193 CYS A CB  1 
ATOM   1481 S SG  A CYS A 1 193 ? 25.88522  -0.28069  34.86823  0.535 22.83171  ? 193 CYS A SG  1 
ATOM   1482 S SG  B CYS A 1 193 ? 25.59948  1.06986   32.12299  0.465 23.07283  ? 193 CYS A SG  1 
ATOM   1483 N N   . LEU A 1 194 ? 23.59683  2.15101   36.66383  1.000 17.57893  ? 194 LEU A N   1 
ATOM   1484 C CA  . LEU A 1 194 ? 23.88194  2.72293   37.96630  1.000 19.98634  ? 194 LEU A CA  1 
ATOM   1485 C C   . LEU A 1 194 ? 25.29547  2.30097   38.35639  1.000 15.77606  ? 194 LEU A C   1 
ATOM   1486 O O   . LEU A 1 194 ? 25.58362  1.10647   38.46345  1.000 16.73201  ? 194 LEU A O   1 
ATOM   1487 C CB  . LEU A 1 194 ? 22.85693  2.22668   38.97666  1.000 17.77737  ? 194 LEU A CB  1 
ATOM   1488 C CG  . LEU A 1 194 ? 21.40932  2.48725   38.55242  1.000 18.36031  ? 194 LEU A CG  1 
ATOM   1489 C CD1 . LEU A 1 194 ? 20.48121  1.84973   39.61130  1.000 17.16485  ? 194 LEU A CD1 1 
ATOM   1490 C CD2 . LEU A 1 194 ? 21.10546  3.97024   38.36078  1.000 17.89705  ? 194 LEU A CD2 1 
ATOM   1491 N N   . THR A 1 195 ? 26.18088  3.25747   38.57321  1.000 16.99988  ? 195 THR A N   1 
ATOM   1492 C CA  . THR A 1 195 ? 27.54180  2.82628   38.87191  1.000 19.67652  ? 195 THR A CA  1 
ATOM   1493 C C   . THR A 1 195 ? 28.10136  3.45895   40.12881  1.000 21.06437  ? 195 THR A C   1 
ATOM   1494 O O   . THR A 1 195 ? 28.97956  2.87950   40.75846  1.000 23.55144  ? 195 THR A O   1 
ATOM   1495 C CB  . THR A 1 195 ? 28.47462  3.13117   37.69256  1.000 26.46812  ? 195 THR A CB  1 
ATOM   1496 O OG1 . THR A 1 195 ? 28.35458  4.52423   37.34936  1.000 25.61967  ? 195 THR A OG1 1 
ATOM   1497 C CG2 . THR A 1 195 ? 28.10083  2.26858   36.51455  1.000 24.53067  ? 195 THR A CG2 1 
ATOM   1498 N N   . GLU A 1 196 ? 27.65222  4.64533   40.49277  1.000 18.62912  ? 196 GLU A N   1 
ATOM   1499 C CA  . GLU A 1 196 ? 28.20120  5.29095   41.67727  1.000 18.98291  ? 196 GLU A CA  1 
ATOM   1500 C C   . GLU A 1 196 ? 27.19856  5.20683   42.82041  1.000 23.13744  ? 196 GLU A C   1 
ATOM   1501 O O   . GLU A 1 196 ? 25.99059  5.19905   42.60059  1.000 17.00767  ? 196 GLU A O   1 
ATOM   1502 C CB  . GLU A 1 196 ? 28.54656  6.74890   41.39002  1.000 24.73098  ? 196 GLU A CB  1 
ATOM   1503 C CG  . GLU A 1 196 ? 29.55007  6.86744   40.24271  1.000 24.09345  ? 196 GLU A CG  1 
ATOM   1504 C CD  . GLU A 1 196 ? 30.93629  6.39344   40.67128  1.000 39.09507  ? 196 GLU A CD  1 
ATOM   1505 O OE1 . GLU A 1 196 ? 31.26279  6.49683   41.87803  1.000 44.42588  ? 196 GLU A OE1 1 
ATOM   1506 O OE2 . GLU A 1 196 ? 31.68854  5.89831   39.81092  1.000 53.22099  ? 196 GLU A OE2 1 
ATOM   1507 N N   . GLN A 1 197 ? 27.70258  5.14681   44.04065  1.000 17.14097  ? 197 GLN A N   1 
ATOM   1508 C CA  . GLN A 1 197 ? 26.81563  5.11046   45.19027  1.000 20.19293  ? 197 GLN A CA  1 
ATOM   1509 C C   . GLN A 1 197 ? 25.86283  6.30085   45.17160  1.000 18.09828  ? 197 GLN A C   1 
ATOM   1510 O O   . GLN A 1 197 ? 26.26750  7.45036   44.96659  1.000 17.67536  ? 197 GLN A O   1 
ATOM   1511 C CB  . GLN A 1 197 ? 27.64021  5.09032   46.47646  1.000 21.92006  ? 197 GLN A CB  1 
ATOM   1512 C CG  . GLN A 1 197 ? 26.78841  5.06182   47.71549  1.000 22.82962  ? 197 GLN A CG  1 
ATOM   1513 C CD  . GLN A 1 197 ? 27.60962  4.91718   48.95342  1.000 24.37487  ? 197 GLN A CD  1 
ATOM   1514 O OE1 . GLN A 1 197 ? 28.33297  5.85442   49.35629  1.000 23.40318  ? 197 GLN A OE1 1 
ATOM   1515 N NE2 . GLN A 1 197 ? 27.50033  3.76504   49.58533  1.000 19.24928  ? 197 GLN A NE2 1 
ATOM   1516 N N   . MET A 1 198 ? 24.57855  6.00616   45.34408  1.000 16.99847  ? 198 MET A N   1 
ATOM   1517 C CA  . MET A 1 198 ? 23.44027  6.93103   45.30345  1.000 16.54390  ? 198 MET A CA  1 
ATOM   1518 C C   . MET A 1 198 ? 23.04152  7.35134   43.88812  1.000 16.70534  ? 198 MET A C   1 
ATOM   1519 O O   . MET A 1 198 ? 22.12323  8.18919   43.76917  1.000 16.93399  ? 198 MET A O   1 
ATOM   1520 C CB  . MET A 1 198 ? 23.64847  8.17984   46.17630  1.000 16.59930  ? 198 MET A CB  1 
ATOM   1521 C CG  . MET A 1 198 ? 23.49731  7.88242   47.69992  1.000 18.32237  ? 198 MET A CG  1 
ATOM   1522 S SD  . MET A 1 198 ? 21.85368  7.16856   48.14844  1.000 26.15840  ? 198 MET A SD  1 
ATOM   1523 C CE  . MET A 1 198 ? 20.69266  8.32069   47.42950  1.000 24.72256  ? 198 MET A CE  1 
ATOM   1524 N N   . ASP A 1 199 ? 23.62207  6.79170   42.81883  1.000 15.71229  ? 199 ASP A N   1 
ATOM   1525 C CA  . ASP A 1 199 ? 22.96759  6.91988   41.51721  1.000 15.06361  ? 199 ASP A CA  1 
ATOM   1526 C C   . ASP A 1 199 ? 21.54275  6.36878   41.60713  1.000 16.59579  ? 199 ASP A C   1 
ATOM   1527 O O   . ASP A 1 199 ? 21.31820  5.27335   42.14942  1.000 11.45347  ? 199 ASP A O   1 
ATOM   1528 C CB  . ASP A 1 199 ? 23.70721  6.13024   40.42547  1.000 15.10149  ? 199 ASP A CB  1 
ATOM   1529 C CG  . ASP A 1 199 ? 24.99308  6.81569   39.91313  1.000 18.67484  ? 199 ASP A CG  1 
ATOM   1530 O OD1 . ASP A 1 199 ? 25.32372  7.93626   40.35920  1.000 20.75402  ? 199 ASP A OD1 1 
ATOM   1531 O OD2 . ASP A 1 199 ? 25.65142  6.17790   39.06309  1.000 21.22498  ? 199 ASP A OD2 1 
ATOM   1532 N N   . THR A 1 200 ? 20.59705  7.05788   40.94885  1.000 16.02788  ? 200 THR A N   1 
ATOM   1533 C CA  . THR A 1 200 ? 19.17206  6.87840   41.20229  1.000 13.78076  ? 200 THR A CA  1 
ATOM   1534 C C   . THR A 1 200 ? 18.41539  6.83115   39.88032  1.000 16.90051  ? 200 THR A C   1 
ATOM   1535 O O   . THR A 1 200 ? 18.82745  7.44000   38.88668  1.000 13.69474  ? 200 THR A O   1 
ATOM   1536 C CB  . THR A 1 200 ? 18.64932  8.00413   42.05870  1.000 13.15957  ? 200 THR A CB  1 
ATOM   1537 O OG1 . THR A 1 200 ? 19.29758  7.95347   43.32711  1.000 17.52828  ? 200 THR A OG1 1 
ATOM   1538 C CG2 . THR A 1 200 ? 17.06350  7.91484   42.26130  1.000 16.07047  ? 200 THR A CG2 1 
ATOM   1539 N N   . MET A 1 201 ? 17.29988  6.09572   39.87656  1.000 16.08047  ? 201 MET A N   1 
ATOM   1540 C CA  . MET A 1 201 ? 16.34885  6.10301   38.77335  1.000 17.15990  ? 201 MET A CA  1 
ATOM   1541 C C   . MET A 1 201 ? 14.94264  6.09584   39.35657  1.000 14.92465  ? 201 MET A C   1 
ATOM   1542 O O   . MET A 1 201 ? 14.65902  5.33676   40.29036  1.000 14.83235  ? 201 MET A O   1 
ATOM   1543 C CB  . MET A 1 201 ? 16.55915  4.89948   37.85566  1.000 15.72219  ? 201 MET A CB  1 
ATOM   1544 C CG  . MET A 1 201 ? 15.64905  4.92650   36.63802  1.000 19.39576  ? 201 MET A CG  1 
ATOM   1545 S SD  . MET A 1 201 ? 14.20075  3.89122   36.81713  1.000 28.81122  ? 201 MET A SD  1 
ATOM   1546 C CE  . MET A 1 201 ? 14.79329  2.25053   36.93376  1.000 18.63451  ? 201 MET A CE  1 
ATOM   1547 N N   . PHE A 1 202 ? 14.07162  6.92416   38.80317  1.000 13.51517  ? 202 PHE A N   1 
ATOM   1548 C CA  . PHE A 1 202 ? 12.64536  6.95161   39.13707  1.000 11.00674  ? 202 PHE A CA  1 
ATOM   1549 C C   . PHE A 1 202 ? 11.85761  6.45008   37.94542  1.000 14.03484  ? 202 PHE A C   1 
ATOM   1550 O O   . PHE A 1 202 ? 12.24652  6.71666   36.80681  1.000 16.33277  ? 202 PHE A O   1 
ATOM   1551 C CB  . PHE A 1 202 ? 12.17095  8.39429   39.44771  1.000 12.03882  ? 202 PHE A CB  1 
ATOM   1552 C CG  . PHE A 1 202 ? 13.08485  9.17475   40.39318  1.000 13.06891  ? 202 PHE A CG  1 
ATOM   1553 C CD1 . PHE A 1 202 ? 12.88777  9.11053   41.76797  1.000 11.44367  ? 202 PHE A CD1 1 
ATOM   1554 C CD2 . PHE A 1 202 ? 14.02877  10.05067  39.90222  1.000 14.25319  ? 202 PHE A CD2 1 
ATOM   1555 C CE1 . PHE A 1 202 ? 13.69235  9.83637   42.63548  1.000 15.99681  ? 202 PHE A CE1 1 
ATOM   1556 C CE2 . PHE A 1 202 ? 14.81717  10.80758  40.74443  1.000 14.95204  ? 202 PHE A CE2 1 
ATOM   1557 C CZ  . PHE A 1 202 ? 14.67706  10.67938  42.12617  1.000 17.17405  ? 202 PHE A CZ  1 
ATOM   1558 N N   . TRP A 1 203 ? 10.69946  5.81727   38.17630  1.000 11.22466  ? 203 TRP A N   1 
ATOM   1559 C CA  . TRP A 1 203 ? 9.91852   5.41147   37.00858  1.000 13.02975  ? 203 TRP A CA  1 
ATOM   1560 C C   . TRP A 1 203 ? 8.42798   5.35693   37.31518  1.000 16.50340  ? 203 TRP A C   1 
ATOM   1561 O O   . TRP A 1 203 ? 8.00187   5.26367   38.47529  1.000 13.14888  ? 203 TRP A O   1 
ATOM   1562 C CB  . TRP A 1 203 ? 10.35853  4.06237   36.45015  1.000 10.95703  ? 203 TRP A CB  1 
ATOM   1563 C CG  . TRP A 1 203 ? 9.93012   2.80661   37.20502  1.000 14.93568  ? 203 TRP A CG  1 
ATOM   1564 C CD1 . TRP A 1 203 ? 8.87020   1.97964   36.89028  1.000 11.26718  ? 203 TRP A CD1 1 
ATOM   1565 C CD2 . TRP A 1 203 ? 10.58270  2.20224   38.36033  1.000 13.54479  ? 203 TRP A CD2 1 
ATOM   1566 N NE1 . TRP A 1 203 ? 8.82702   0.91728   37.76913  1.000 13.56603  ? 203 TRP A NE1 1 
ATOM   1567 C CE2 . TRP A 1 203 ? 9.86800   1.02456   38.67138  1.000 11.19960  ? 203 TRP A CE2 1 
ATOM   1568 C CE3 . TRP A 1 203 ? 11.72654  2.53293   39.13020  1.000 14.36333  ? 203 TRP A CE3 1 
ATOM   1569 C CZ2 . TRP A 1 203 ? 10.23592  0.16226   39.73933  1.000 10.87069  ? 203 TRP A CZ2 1 
ATOM   1570 C CZ3 . TRP A 1 203 ? 12.08781  1.67093   40.21551  1.000 12.79377  ? 203 TRP A CZ3 1 
ATOM   1571 C CH2 . TRP A 1 203 ? 11.34330  0.51320   40.50712  1.000 14.25803  ? 203 TRP A CH2 1 
ATOM   1572 N N   . SER A 1 204 ? 7.64531   5.41837   36.23639  1.000 14.12968  ? 204 SER A N   1 
ATOM   1573 C CA  . SER A 1 204 ? 6.19283   5.19782   36.25877  1.000 18.32026  ? 204 SER A CA  1 
ATOM   1574 C C   . SER A 1 204 ? 5.89802   3.75872   35.89647  1.000 15.64837  ? 204 SER A C   1 
ATOM   1575 O O   . SER A 1 204 ? 5.99391   3.36175   34.71420  1.000 14.12934  ? 204 SER A O   1 
ATOM   1576 C CB  . SER A 1 204 ? 5.47204   6.14785   35.29583  1.000 19.23993  ? 204 SER A CB  1 
ATOM   1577 O OG  . SER A 1 204 ? 5.83465   7.47565   35.63543  1.000 20.84651  ? 204 SER A OG  1 
ATOM   1578 N N   . ASP A 1 205 ? 5.46496   2.98683   36.90852  1.000 14.76478  ? 205 ASP A N   1 
ATOM   1579 C CA  . ASP A 1 205 ? 5.44017   1.53897   36.77814  1.000 15.29524  ? 205 ASP A CA  1 
ATOM   1580 C C   . ASP A 1 205 ? 4.28305   1.06426   35.88750  1.000 19.73006  ? 205 ASP A C   1 
ATOM   1581 O O   . ASP A 1 205 ? 4.28172   -0.08641  35.44809  1.000 16.88772  ? 205 ASP A O   1 
ATOM   1582 C CB  . ASP A 1 205 ? 5.35226   0.92083   38.18094  1.000 15.92118  ? 205 ASP A CB  1 
ATOM   1583 C CG  . ASP A 1 205 ? 5.48554   -0.56720  38.17175  1.000 20.61804  ? 205 ASP A CG  1 
ATOM   1584 O OD1 . ASP A 1 205 ? 6.60082   -1.03355  37.84366  1.000 16.14790  ? 205 ASP A OD1 1 
ATOM   1585 O OD2 . ASP A 1 205 ? 4.48125   -1.27671  38.48204  1.000 19.02625  ? 205 ASP A OD2 1 
ATOM   1586 N N   . GLY A 1 206 ? 3.31532   1.92330   35.60236  1.000 17.47607  ? 206 GLY A N   1 
ATOM   1587 C CA  . GLY A 1 206 ? 2.24435   1.61066   34.65985  1.000 19.93125  ? 206 GLY A CA  1 
ATOM   1588 C C   . GLY A 1 206 ? 2.57178   1.98681   33.22860  1.000 21.48250  ? 206 GLY A C   1 
ATOM   1589 O O   . GLY A 1 206 ? 1.89085   1.58020   32.28851  1.000 22.87300  ? 206 GLY A O   1 
ATOM   1590 N N   . GLN A 1 207 ? 3.66760   2.71678   33.02891  1.000 18.09848  ? 207 GLN A N   1 
ATOM   1591 C CA  . GLN A 1 207 ? 4.01932   3.24965   31.72184  1.000 24.07655  ? 207 GLN A CA  1 
ATOM   1592 C C   . GLN A 1 207 ? 5.12780   2.45981   31.01598  1.000 27.34865  ? 207 GLN A C   1 
ATOM   1593 O O   . GLN A 1 207 ? 5.23290   2.52342   29.78938  1.000 21.05091  ? 207 GLN A O   1 
ATOM   1594 C CB  . GLN A 1 207 ? 4.45024   4.70278   31.90673  1.000 23.68205  ? 207 GLN A CB  1 
ATOM   1595 C CG  . GLN A 1 207 ? 4.36778   5.61208   30.69961  1.000 31.22891  ? 207 GLN A CG  1 
ATOM   1596 C CD  . GLN A 1 207 ? 4.44186   7.05346   31.13549  1.000 31.13628  ? 207 GLN A CD  1 
ATOM   1597 O OE1 . GLN A 1 207 ? 3.87079   7.43707   32.16865  1.000 34.26792  ? 207 GLN A OE1 1 
ATOM   1598 N NE2 . GLN A 1 207 ? 5.18930   7.85770   30.38950  1.000 29.71855  ? 207 GLN A NE2 1 
ATOM   1599 N N   . ILE A 1 208 ? 5.97193   1.72561   31.74720  1.000 20.20746  ? 208 ILE A N   1 
ATOM   1600 C CA  . ILE A 1 208 ? 7.07089   0.97030   31.14690  1.000 19.18536  ? 208 ILE A CA  1 
ATOM   1601 C C   . ILE A 1 208 ? 7.10255   -0.41446  31.77079  1.000 16.91012  ? 208 ILE A C   1 
ATOM   1602 O O   . ILE A 1 208 ? 6.43082   -0.70449  32.76530  1.000 19.48681  ? 208 ILE A O   1 
ATOM   1603 C CB  . ILE A 1 208 ? 8.45627   1.64219   31.36534  1.000 17.16896  ? 208 ILE A CB  1 
ATOM   1604 C CG1 . ILE A 1 208 ? 8.79736   1.72824   32.88652  1.000 16.58171  ? 208 ILE A CG1 1 
ATOM   1605 C CG2 . ILE A 1 208 ? 8.53198   2.97273   30.66434  1.000 19.68452  ? 208 ILE A CG2 1 
ATOM   1606 C CD1 . ILE A 1 208 ? 10.32490  2.00333   33.23508  1.000 15.93617  ? 208 ILE A CD1 1 
ATOM   1607 N N   . LEU A 1 209 ? 7.93359   -1.26092  31.19813  1.000 14.80206  ? 209 LEU A N   1 
ATOM   1608 C CA  . LEU A 1 209 ? 8.40774   -2.46826  31.85296  1.000 18.36705  ? 209 LEU A CA  1 
ATOM   1609 C C   . LEU A 1 209 ? 9.89827   -2.26826  32.09744  1.000 14.54777  ? 209 LEU A C   1 
ATOM   1610 O O   . LEU A 1 209 ? 10.53761  -1.45066  31.43180  1.000 18.75308  ? 209 LEU A O   1 
ATOM   1611 C CB  . LEU A 1 209 ? 8.17539   -3.72337  30.98803  1.000 17.03009  ? 209 LEU A CB  1 
ATOM   1612 C CG  . LEU A 1 209 ? 6.69730   -4.04658  30.61638  1.000 20.67419  ? 209 LEU A CG  1 
ATOM   1613 C CD1 . LEU A 1 209 ? 6.59650   -5.19237  29.59264  1.000 23.72070  ? 209 LEU A CD1 1 
ATOM   1614 C CD2 . LEU A 1 209 ? 5.95436   -4.41673  31.88334  1.000 16.32730  ? 209 LEU A CD2 1 
ATOM   1615 N N   . HIS A 1 210 ? 10.46474  -3.06424  32.99160  1.000 16.58853  ? 210 HIS A N   1 
ATOM   1616 C CA  . HIS A 1 210 ? 11.89211  -2.91934  33.24910  1.000 19.16536  ? 210 HIS A CA  1 
ATOM   1617 C C   . HIS A 1 210 ? 12.51303  -4.27758  33.52896  1.000 20.62439  ? 210 HIS A C   1 
ATOM   1618 O O   . HIS A 1 210 ? 11.82164  -5.28119  33.76661  1.000 20.32480  ? 210 HIS A O   1 
ATOM   1619 C CB  . HIS A 1 210 ? 12.13491  -1.94593  34.41128  1.000 16.80605  ? 210 HIS A CB  1 
ATOM   1620 C CG  . HIS A 1 210 ? 11.54327  -2.40724  35.69930  1.000 17.97480  ? 210 HIS A CG  1 
ATOM   1621 N ND1 . HIS A 1 210 ? 10.24347  -2.11351  36.07184  1.000 16.08605  ? 210 HIS A ND1 1 
ATOM   1622 C CD2 . HIS A 1 210 ? 12.04881  -3.19596  36.67394  1.000 19.36726  ? 210 HIS A CD2 1 
ATOM   1623 C CE1 . HIS A 1 210 ? 9.98151   -2.68997  37.23619  1.000 18.14353  ? 210 HIS A CE1 1 
ATOM   1624 N NE2 . HIS A 1 210 ? 11.06573  -3.34177  37.62319  1.000 20.76571  ? 210 HIS A NE2 1 
ATOM   1625 N N   . ALA A 1 211 ? 13.84353  -4.29801  33.48428  1.000 19.46953  ? 211 ALA A N   1 
ATOM   1626 C CA  . ALA A 1 211 ? 14.62467  -5.48399  33.81261  1.000 20.51798  ? 211 ALA A CA  1 
ATOM   1627 C C   . ALA A 1 211 ? 16.05335  -5.03991  34.09072  1.000 19.10408  ? 211 ALA A C   1 
ATOM   1628 O O   . ALA A 1 211 ? 16.45536  -3.92194  33.75425  1.000 20.71437  ? 211 ALA A O   1 
ATOM   1629 C CB  . ALA A 1 211 ? 14.61895  -6.49800  32.65464  1.000 21.91764  ? 211 ALA A CB  1 
ATOM   1630 N N   . VAL A 1 212 ? 16.84765  -5.94336  34.63350  1.000 20.62447  ? 212 VAL A N   1 
ATOM   1631 C CA  . VAL A 1 212 ? 18.26697  -5.65709  34.81851  1.000 21.37332  ? 212 VAL A CA  1 
ATOM   1632 C C   . VAL A 1 212 ? 19.08832  -6.82815  34.30496  1.000 18.95606  ? 212 VAL A C   1 
ATOM   1633 O O   . VAL A 1 212 ? 18.70291  -7.99078  34.49530  1.000 26.31042  ? 212 VAL A O   1 
ATOM   1634 C CB  . VAL A 1 212 ? 18.56720  -5.37785  36.30077  1.000 22.20643  ? 212 VAL A CB  1 
ATOM   1635 C CG1 . VAL A 1 212 ? 18.11298  -6.55729  37.16157  1.000 25.53142  ? 212 VAL A CG1 1 
ATOM   1636 C CG2 . VAL A 1 212 ? 20.06529  -5.07009  36.52393  1.000 19.77553  ? 212 VAL A CG2 1 
ATOM   1637 N N   . ARG A 1 213 ? 20.22721  -6.53253  33.68267  1.000 19.64515  ? 213 ARG A N   1 
ATOM   1638 C CA  . ARG A 1 213 ? 21.10860  -7.59265  33.20863  1.000 20.06104  ? 213 ARG A CA  1 
ATOM   1639 C C   . ARG A 1 213 ? 21.86135  -8.22230  34.38665  1.000 23.84080  ? 213 ARG A C   1 
ATOM   1640 O O   . ARG A 1 213 ? 22.09099  -7.57282  35.41197  1.000 23.13562  ? 213 ARG A O   1 
ATOM   1641 C CB  . ARG A 1 213 ? 22.12113  -7.05562  32.18773  1.000 21.41299  ? 213 ARG A CB  1 
ATOM   1642 C CG  . ARG A 1 213 ? 21.53159  -6.51266  30.82615  1.000 27.93288  ? 213 ARG A CG  1 
ATOM   1643 C CD  . ARG A 1 213 ? 22.64682  -6.42893  29.73107  1.000 29.58973  ? 213 ARG A CD  1 
ATOM   1644 N NE  . ARG A 1 213 ? 22.20769  -5.93141  28.42817  1.000 33.71051  ? 213 ARG A NE  1 
ATOM   1645 C CZ  . ARG A 1 213 ? 21.62846  -6.67374  27.48511  1.000 42.00981  ? 213 ARG A CZ  1 
ATOM   1646 N NH1 . ARG A 1 213 ? 21.35928  -7.95417  27.67716  1.000 37.62287  ? 213 ARG A NH1 1 
ATOM   1647 N NH2 . ARG A 1 213 ? 21.31156  -6.11562  26.31546  1.000 45.07514  ? 213 ARG A NH2 1 
ATOM   1648 N N   . PRO A 1 214 ? 22.24610  -9.49556  34.27038  1.000 24.18317  ? 214 PRO A N   1 
ATOM   1649 C CA  . PRO A 1 214 ? 23.04855  -10.12841 35.33211  1.000 25.54691  ? 214 PRO A CA  1 
ATOM   1650 C C   . PRO A 1 214 ? 24.34582  -9.37680  35.53881  1.000 19.89411  ? 214 PRO A C   1 
ATOM   1651 O O   . PRO A 1 214 ? 24.86093  -8.75626  34.60848  1.000 21.71239  ? 214 PRO A O   1 
ATOM   1652 C CB  . PRO A 1 214 ? 23.31602  -11.53359 34.77347  1.000 26.06029  ? 214 PRO A CB  1 
ATOM   1653 C CG  . PRO A 1 214 ? 22.18147  -11.76124 33.81189  1.000 36.47564  ? 214 PRO A CG  1 
ATOM   1654 C CD  . PRO A 1 214 ? 21.92371  -10.43784 33.17935  1.000 26.92110  ? 214 PRO A CD  1 
ATOM   1655 N N   . ILE A 1 215 ? 24.88958  -9.43036  36.77957  1.000 20.80610  ? 215 ILE A N   1 
ATOM   1656 C CA  . ILE A 1 215 ? 26.24056  -8.88876  37.01367  1.000 21.83998  ? 215 ILE A CA  1 
ATOM   1657 C C   . ILE A 1 215 ? 27.25402  -10.01455 36.81441  1.000 26.30574  ? 215 ILE A C   1 
ATOM   1658 O O   . ILE A 1 215 ? 26.92303  -11.19964 36.91137  1.000 18.87137  ? 215 ILE A O   1 
ATOM   1659 C CB  . ILE A 1 215 ? 26.41753  -8.25919  38.41230  1.000 18.99292  ? 215 ILE A CB  1 
ATOM   1660 C CG1 . ILE A 1 215 ? 26.13987  -9.30247  39.50320  1.000 20.90826  ? 215 ILE A CG1 1 
ATOM   1661 C CG2 . ILE A 1 215 ? 25.49429  -7.03500  38.61070  1.000 20.53956  ? 215 ILE A CG2 1 
ATOM   1662 C CD1 . ILE A 1 215 ? 26.40474  -8.80543  40.89627  1.000 18.30948  ? 215 ILE A CD1 1 
ATOM   1663 N N   . HIS A 1 216 ? 28.50665  -9.65488  36.54271  1.000 22.13613  ? 216 HIS A N   1 
ATOM   1664 C CA  . HIS A 1 216 ? 29.53403  -10.68062 36.52669  1.000 28.83965  ? 216 HIS A CA  1 
ATOM   1665 C C   . HIS A 1 216 ? 30.81371  -10.13176 37.14362  1.000 23.75548  ? 216 HIS A C   1 
ATOM   1666 O O   . HIS A 1 216 ? 31.03002  -8.91639  37.17246  1.000 23.29513  ? 216 HIS A O   1 
ATOM   1667 C CB  . HIS A 1 216 ? 29.78734  -11.21278 35.10318  1.000 31.22709  ? 216 HIS A CB  1 
ATOM   1668 C CG  . HIS A 1 216 ? 30.05716  -10.14384 34.10019  1.000 34.99735  ? 216 HIS A CG  1 
ATOM   1669 N ND1 . HIS A 1 216 ? 29.05676  -9.54707  33.36317  1.000 39.83784  ? 216 HIS A ND1 1 
ATOM   1670 C CD2 . HIS A 1 216 ? 31.21570  -9.56367  33.70460  1.000 42.91601  ? 216 HIS A CD2 1 
ATOM   1671 C CE1 . HIS A 1 216 ? 29.58867  -8.63425  32.56426  1.000 38.82472  ? 216 HIS A CE1 1 
ATOM   1672 N NE2 . HIS A 1 216 ? 30.89753  -8.63265  32.74487  1.000 43.80279  ? 216 HIS A NE2 1 
ATOM   1673 N N   . PRO A 1 217 ? 31.67343  -11.01143 37.64704  1.000 22.38139  ? 217 PRO A N   1 
ATOM   1674 C CA  . PRO A 1 217 ? 32.89121  -10.53033 38.32923  1.000 26.07564  ? 217 PRO A CA  1 
ATOM   1675 C C   . PRO A 1 217 ? 33.90709  -9.95371  37.35716  1.000 24.93003  ? 217 PRO A C   1 
ATOM   1676 O O   . PRO A 1 217 ? 34.06654  -10.42679 36.23103  1.000 29.96801  ? 217 PRO A O   1 
ATOM   1677 C CB  . PRO A 1 217 ? 33.43337  -11.77918 39.02517  1.000 21.12457  ? 217 PRO A CB  1 
ATOM   1678 C CG  . PRO A 1 217 ? 32.79682  -12.93904 38.29534  1.000 28.83925  ? 217 PRO A CG  1 
ATOM   1679 C CD  . PRO A 1 217 ? 31.48442  -12.46473 37.77259  1.000 25.51274  ? 217 PRO A CD  1 
ATOM   1680 N N   . VAL A 1 218 ? 34.55571  -8.87993  37.78421  1.000 22.41034  ? 218 VAL A N   1 
ATOM   1681 C CA  . VAL A 1 218 ? 35.66256  -8.32566  37.01395  1.000 29.04725  ? 218 VAL A CA  1 
ATOM   1682 C C   . VAL A 1 218 ? 36.91557  -9.17165  37.21813  1.000 32.09110  ? 218 VAL A C   1 
ATOM   1683 O O   . VAL A 1 218 ? 37.48498  -9.72398  36.27155  1.000 25.07205  ? 218 VAL A O   1 
ATOM   1684 C CB  . VAL A 1 218 ? 35.90578  -6.86613  37.40415  1.000 20.38011  ? 218 VAL A CB  1 
ATOM   1685 C CG1 . VAL A 1 218 ? 37.18108  -6.35690  36.71615  1.000 29.25403  ? 218 VAL A CG1 1 
ATOM   1686 C CG2 . VAL A 1 218 ? 34.69585  -6.01626  37.02749  1.000 24.86168  ? 218 VAL A CG2 1 
ATOM   1687 N N   . ASP A 1 219 ? 37.31351  -9.33664  38.45502  1.000 24.27129  ? 219 ASP A N   1 
ATOM   1688 C CA  . ASP A 1 219 ? 38.28662  -10.35080 38.81502  1.000 27.85742  ? 219 ASP A CA  1 
ATOM   1689 C C   . ASP A 1 219 ? 37.49439  -11.62893 38.97096  1.000 28.82059  ? 219 ASP A C   1 
ATOM   1690 O O   . ASP A 1 219 ? 36.70667  -11.74706 39.91460  1.000 27.18684  ? 219 ASP A O   1 
ATOM   1691 C CB  . ASP A 1 219 ? 39.01278  -9.93957  40.10476  1.000 27.95227  ? 219 ASP A CB  1 
ATOM   1692 C CG  . ASP A 1 219 ? 39.75902  -11.07696 40.77600  1.000 31.25743  ? 219 ASP A CG  1 
ATOM   1693 O OD1 . ASP A 1 219 ? 39.80670  -12.21238 40.23180  1.000 34.61998  ? 219 ASP A OD1 1 
ATOM   1694 O OD2 . ASP A 1 219 ? 40.25912  -10.82364 41.90327  1.000 25.25951  ? 219 ASP A OD2 1 
ATOM   1695 N N   . PRO A 1 220 ? 37.67072  -12.60803 38.07783  1.000 31.65744  ? 220 PRO A N   1 
ATOM   1696 C CA  . PRO A 1 220 ? 36.75861  -13.75673 38.05755  1.000 29.43578  ? 220 PRO A CA  1 
ATOM   1697 C C   . PRO A 1 220 ? 36.98860  -14.74134 39.18677  1.000 30.21832  ? 220 PRO A C   1 
ATOM   1698 O O   . PRO A 1 220 ? 36.21886  -15.69659 39.32732  1.000 35.99465  ? 220 PRO A O   1 
ATOM   1699 C CB  . PRO A 1 220 ? 37.04228  -14.39173 36.68998  1.000 35.52039  ? 220 PRO A CB  1 
ATOM   1700 C CG  . PRO A 1 220 ? 38.46638  -14.07545 36.42747  1.000 32.33170  ? 220 PRO A CG  1 
ATOM   1701 C CD  . PRO A 1 220 ? 38.66608  -12.68083 36.98913  1.000 39.06439  ? 220 PRO A CD  1 
ATOM   1702 N N   . THR A 1 221 ? 37.98153  -14.52327 40.02961  1.000 30.16627  ? 221 THR A N   1 
ATOM   1703 C CA  . THR A 1 221 ? 38.22033  -15.39611 41.17331  1.000 34.70066  ? 221 THR A CA  1 
ATOM   1704 C C   . THR A 1 221 ? 37.52232  -14.93353 42.45147  1.000 37.44496  ? 221 THR A C   1 
ATOM   1705 O O   . THR A 1 221 ? 37.60104  -15.64245 43.46635  1.000 37.91674  ? 221 THR A O   1 
ATOM   1706 C CB  . THR A 1 221 ? 39.74270  -15.50889 41.42420  1.000 36.42642  ? 221 THR A CB  1 
ATOM   1707 O OG1 . THR A 1 221 ? 40.24042  -14.25685 41.92196  1.000 29.93424  ? 221 THR A OG1 1 
ATOM   1708 C CG2 . THR A 1 221 ? 40.48617  -15.84922 40.10948  1.000 27.80452  ? 221 THR A CG2 1 
ATOM   1709 N N   . LYS A 1 222 ? 36.84267  -13.77755 42.42471  1.000 33.52745  ? 222 LYS A N   1 
ATOM   1710 C CA  . LYS A 1 222 ? 36.10683  -13.22738 43.56043  1.000 30.31694  ? 222 LYS A CA  1 
ATOM   1711 C C   . LYS A 1 222 ? 34.66330  -12.94172 43.13457  1.000 28.27316  ? 222 LYS A C   1 
ATOM   1712 O O   . LYS A 1 222 ? 34.34827  -12.84171 41.94508  1.000 23.96223  ? 222 LYS A O   1 
ATOM   1713 C CB  . LYS A 1 222 ? 36.73423  -11.91431 44.09291  1.000 31.77354  ? 222 LYS A CB  1 
ATOM   1714 C CG  . LYS A 1 222 ? 38.25175  -11.90791 44.38341  1.000 36.22484  ? 222 LYS A CG  1 
ATOM   1715 C CD  . LYS A 1 222 ? 38.55081  -12.18532 45.84632  1.000 46.96601  ? 222 LYS A CD  1 
ATOM   1716 C CE  . LYS A 1 222 ? 40.06695  -12.24369 46.15451  1.000 34.31413  ? 222 LYS A CE  1 
ATOM   1717 N NZ  . LYS A 1 222 ? 40.55353  -10.99590 46.80260  1.000 30.01166  ? 222 LYS A NZ  1 
ATOM   1718 N N   . ALA A 1 223 ? 33.78220  -12.81990 44.12344  1.000 26.48890  ? 223 ALA A N   1 
ATOM   1719 C CA  . ALA A 1 223 ? 32.37878  -12.58186 43.83062  1.000 30.27855  ? 223 ALA A CA  1 
ATOM   1720 C C   . ALA A 1 223 ? 32.18375  -11.16111 43.32502  1.000 22.19418  ? 223 ALA A C   1 
ATOM   1721 O O   . ALA A 1 223 ? 32.95923  -10.24728 43.64140  1.000 23.24654  ? 223 ALA A O   1 
ATOM   1722 C CB  . ALA A 1 223 ? 31.51644  -12.79464 45.07145  1.000 28.29955  ? 223 ALA A CB  1 
ATOM   1723 N N   . ALA A 1 224 ? 31.16092  -10.98542 42.50047  1.000 23.51598  ? 224 ALA A N   1 
ATOM   1724 C CA  . ALA A 1 224 ? 30.64407  -9.65816  42.17711  1.000 18.40386  ? 224 ALA A CA  1 
ATOM   1725 C C   . ALA A 1 224 ? 29.42014  -9.41353  43.07586  1.000 20.47425  ? 224 ALA A C   1 
ATOM   1726 O O   . ALA A 1 224 ? 28.63754  -10.33655 43.30797  1.000 20.29742  ? 224 ALA A O   1 
ATOM   1727 C CB  . ALA A 1 224 ? 30.24095  -9.58563  40.70842  1.000 19.00537  ? 224 ALA A CB  1 
ATOM   1728 N N   . VAL A 1 225 ? 29.26785  -8.18839  43.59133  1.000 16.04646  ? 225 VAL A N   1 
ATOM   1729 C CA  . VAL A 1 225 ? 28.16000  -7.83310  44.49776  1.000 13.80279  ? 225 VAL A CA  1 
ATOM   1730 C C   . VAL A 1 225 ? 27.53795  -6.51502  44.04237  1.000 15.76499  ? 225 VAL A C   1 
ATOM   1731 O O   . VAL A 1 225 ? 28.26496  -5.54757  43.78294  1.000 15.36877  ? 225 VAL A O   1 
ATOM   1732 C CB  . VAL A 1 225 ? 28.63280  -7.70549  45.94784  1.000 16.13198  ? 225 VAL A CB  1 
ATOM   1733 C CG1 . VAL A 1 225 ? 27.43792  -7.35944  46.89183  1.000 19.39526  ? 225 VAL A CG1 1 
ATOM   1734 C CG2 . VAL A 1 225 ? 29.28643  -8.99254  46.40467  1.000 22.38143  ? 225 VAL A CG2 1 
ATOM   1735 N N   . ARG A 1 226 ? 26.19091  -6.45832  43.98128  1.000 16.22683  ? 226 ARG A N   1 
ATOM   1736 C CA  . ARG A 1 226 ? 25.46504  -5.20516  43.69451  1.000 14.30474  ? 226 ARG A CA  1 
ATOM   1737 C C   . ARG A 1 226 ? 24.34612  -5.00100  44.71548  1.000 12.78463  ? 226 ARG A C   1 
ATOM   1738 O O   . ARG A 1 226 ? 23.49059  -5.87406  44.87125  1.000 13.78971  ? 226 ARG A O   1 
ATOM   1739 C CB  . ARG A 1 226 ? 24.89313  -5.20689  42.28216  1.000 16.07434  ? 226 ARG A CB  1 
ATOM   1740 C CG  . ARG A 1 226 ? 24.10246  -3.94605  41.87793  1.000 17.97386  ? 226 ARG A CG  1 
ATOM   1741 C CD  . ARG A 1 226 ? 23.60852  -4.15565  40.40160  1.000 24.74086  ? 226 ARG A CD  1 
ATOM   1742 N NE  . ARG A 1 226 ? 22.86537  -3.04756  39.79917  1.000 22.23102  ? 226 ARG A NE  1 
ATOM   1743 C CZ  . ARG A 1 226 ? 21.54038  -2.93463  39.73251  1.000 23.77739  ? 226 ARG A CZ  1 
ATOM   1744 N NH1 . ARG A 1 226 ? 20.71347  -3.88454  40.19550  1.000 20.16918  ? 226 ARG A NH1 1 
ATOM   1745 N NH2 . ARG A 1 226 ? 21.02232  -1.84049  39.18670  1.000 23.20703  ? 226 ARG A NH2 1 
ATOM   1746 N N   . ASP A 1 227 ? 24.38366  -3.88073  45.42855  1.000 12.70673  ? 227 ASP A N   1 
ATOM   1747 C CA  . ASP A 1 227 ? 23.43945  -3.56849  46.51786  1.000 12.41049  ? 227 ASP A CA  1 
ATOM   1748 C C   . ASP A 1 227 ? 22.52946  -2.44183  46.05847  1.000 12.54403  ? 227 ASP A C   1 
ATOM   1749 O O   . ASP A 1 227 ? 23.02589  -1.37228  45.71701  1.000 11.77454  ? 227 ASP A O   1 
ATOM   1750 C CB  . ASP A 1 227 ? 24.16334  -3.09576  47.77518  1.000 13.46060  ? 227 ASP A CB  1 
ATOM   1751 C CG  . ASP A 1 227 ? 24.98306  -4.20455  48.44111  1.000 15.89028  ? 227 ASP A CG  1 
ATOM   1752 O OD1 . ASP A 1 227 ? 24.61467  -5.38720  48.32269  1.000 16.26437  ? 227 ASP A OD1 1 
ATOM   1753 O OD2 . ASP A 1 227 ? 25.96271  -3.85521  49.08869  1.000 15.98370  ? 227 ASP A OD2 1 
ATOM   1754 N N   . VAL A 1 228 ? 21.21441  -2.66541  46.05696  1.000 14.84466  ? 228 VAL A N   1 
ATOM   1755 C CA  . VAL A 1 228 ? 20.28367  -1.59982  45.67941  1.000 9.03541   ? 228 VAL A CA  1 
ATOM   1756 C C   . VAL A 1 228 ? 19.19694  -1.46962  46.73919  1.000 14.62140  ? 228 VAL A C   1 
ATOM   1757 O O   . VAL A 1 228 ? 18.84438  -2.43987  47.41295  1.000 13.08615  ? 228 VAL A O   1 
ATOM   1758 C CB  . VAL A 1 228 ? 19.64685  -1.83424  44.29519  1.000 13.40784  ? 228 VAL A CB  1 
ATOM   1759 C CG1 . VAL A 1 228 ? 20.74290  -1.80114  43.16299  1.000 13.69446  ? 228 VAL A CG1 1 
ATOM   1760 C CG2 . VAL A 1 228 ? 18.79910  -3.14778  44.28140  1.000 12.33322  ? 228 VAL A CG2 1 
ATOM   1761 N N   . LEU A 1 229 ? 18.67150  -0.25365  46.87464  1.000 10.54187  ? 229 LEU A N   1 
ATOM   1762 C CA  . LEU A 1 229 ? 17.49634  0.05360   47.68241  1.000 10.75988  ? 229 LEU A CA  1 
ATOM   1763 C C   . LEU A 1 229 ? 16.38252  0.38482   46.69481  1.000 11.69741  ? 229 LEU A C   1 
ATOM   1764 O O   . LEU A 1 229 ? 16.56056  1.27837   45.86467  1.000 9.94951   ? 229 LEU A O   1 
ATOM   1765 C CB  . LEU A 1 229 ? 17.76435  1.26374   48.59357  1.000 12.44992  ? 229 LEU A CB  1 
ATOM   1766 C CG  . LEU A 1 229 ? 16.57969  1.85388   49.36029  1.000 12.28151  ? 229 LEU A CG  1 
ATOM   1767 C CD1 . LEU A 1 229 ? 15.94824  0.84503   50.28076  1.000 13.07919  ? 229 LEU A CD1 1 
ATOM   1768 C CD2 . LEU A 1 229 ? 16.98651  3.16492   50.12720  1.000 12.30468  ? 229 LEU A CD2 1 
ATOM   1769 N N   . ILE A 1 230 ? 15.25077  -0.32867  46.77065  1.000 11.18278  ? 230 ILE A N   1 
ATOM   1770 C CA  . ILE A 1 230 ? 14.13661  -0.07281  45.85220  1.000 14.15294  ? 230 ILE A CA  1 
ATOM   1771 C C   . ILE A 1 230 ? 12.90717  0.29100   46.66703  1.000 13.78068  ? 230 ILE A C   1 
ATOM   1772 O O   . ILE A 1 230 ? 12.63101  -0.35485  47.67878  1.000 14.15076  ? 230 ILE A O   1 
ATOM   1773 C CB  . ILE A 1 230 ? 13.85672  -1.29852  44.95531  1.000 15.17768  ? 230 ILE A CB  1 
ATOM   1774 C CG1 . ILE A 1 230 ? 15.08111  -1.58421  44.03226  1.000 15.01798  ? 230 ILE A CG1 1 
ATOM   1775 C CG2 . ILE A 1 230 ? 12.50287  -1.14247  44.12567  1.000 12.01361  ? 230 ILE A CG2 1 
ATOM   1776 C CD1 . ILE A 1 230 ? 14.98283  -2.93445  43.36006  1.000 21.30064  ? 230 ILE A CD1 1 
ATOM   1777 N N   . MET A 1 231 ? 12.15963  1.32212   46.23667  1.000 11.31728  ? 231 MET A N   1 
ATOM   1778 C CA  . MET A 1 231 ? 10.88017  1.58448   46.88449  1.000 11.64280  ? 231 MET A CA  1 
ATOM   1779 C C   . MET A 1 231 ? 9.77860   1.65238   45.83638  1.000 14.18848  ? 231 MET A C   1 
ATOM   1780 O O   . MET A 1 231 ? 10.01496  2.08144   44.70435  1.000 15.32584  ? 231 MET A O   1 
ATOM   1781 C CB  . MET A 1 231 ? 10.93091  2.86876   47.71667  1.000 14.48184  ? 231 MET A CB  1 
ATOM   1782 C CG  . MET A 1 231 ? 11.66623  2.63912   49.06705  1.000 15.91751  ? 231 MET A CG  1 
ATOM   1783 S SD  . MET A 1 231 ? 11.88757  4.09036   50.14641  1.000 20.17682  ? 231 MET A SD  1 
ATOM   1784 C CE  . MET A 1 231 ? 13.09521  5.09262   49.22854  1.000 16.77825  ? 231 MET A CE  1 
ATOM   1785 N N   . GLY A 1 232 ? 8.60652   1.12856   46.17769  1.000 12.01663  ? 232 GLY A N   1 
ATOM   1786 C CA  . GLY A 1 232 ? 7.49064   1.14713   45.27417  1.000 11.22074  ? 232 GLY A CA  1 
ATOM   1787 C C   . GLY A 1 232 ? 6.28362   1.77815   45.97192  1.000 13.77621  ? 232 GLY A C   1 
ATOM   1788 O O   . GLY A 1 232 ? 5.88372   1.35989   47.06547  1.000 13.28120  ? 232 GLY A O   1 
ATOM   1789 N N   . TYR A 1 233 ? 5.67203   2.75230   45.32808  1.000 12.15502  ? 233 TYR A N   1 
ATOM   1790 C CA  . TYR A 1 233 ? 4.67132   3.58021   45.97727  1.000 10.89784  ? 233 TYR A CA  1 
ATOM   1791 C C   . TYR A 1 233 ? 3.34890   3.27135   45.30463  1.000 13.86359  ? 233 TYR A C   1 
ATOM   1792 O O   . TYR A 1 233 ? 3.25125   3.36368   44.07195  1.000 15.69369  ? 233 TYR A O   1 
ATOM   1793 C CB  . TYR A 1 233 ? 5.00374   5.06750   45.79146  1.000 11.71979  ? 233 TYR A CB  1 
ATOM   1794 C CG  . TYR A 1 233 ? 6.25802   5.57583   46.39202  1.000 10.61222  ? 233 TYR A CG  1 
ATOM   1795 C CD1 . TYR A 1 233 ? 7.52911   5.17958   45.90032  1.000 11.29455  ? 233 TYR A CD1 1 
ATOM   1796 C CD2 . TYR A 1 233 ? 6.21310   6.44284   47.49468  1.000 11.62932  ? 233 TYR A CD2 1 
ATOM   1797 C CE1 . TYR A 1 233 ? 8.69205   5.70119   46.47312  1.000 12.91938  ? 233 TYR A CE1 1 
ATOM   1798 C CE2 . TYR A 1 233 ? 7.37214   6.94633   48.05694  1.000 9.26384   ? 233 TYR A CE2 1 
ATOM   1799 C CZ  . TYR A 1 233 ? 8.60624   6.56802   47.55546  1.000 14.93093  ? 233 TYR A CZ  1 
ATOM   1800 O OH  . TYR A 1 233 ? 9.75665   7.10035   48.12287  1.000 13.50904  ? 233 TYR A OH  1 
ATOM   1801 N N   . LYS A 1 234 ? 2.32586   2.95326   46.10769  1.000 13.60243  ? 234 LYS A N   1 
ATOM   1802 C CA  . LYS A 1 234 ? 0.99921   2.71279   45.58299  1.000 15.65214  ? 234 LYS A CA  1 
ATOM   1803 C C   . LYS A 1 234 ? -0.02248  3.60866   46.28998  1.000 15.11928  ? 234 LYS A C   1 
ATOM   1804 O O   . LYS A 1 234 ? -0.08753  3.63058   47.51702  1.000 13.28211  ? 234 LYS A O   1 
ATOM   1805 C CB  . LYS A 1 234 ? 0.62404   1.21754   45.74337  1.000 15.83990  ? 234 LYS A CB  1 
ATOM   1806 C CG  . LYS A 1 234 ? -0.43858  0.81053   44.72796  1.000 33.24601  ? 234 LYS A CG  1 
ATOM   1807 C CD  . LYS A 1 234 ? -0.82325  -0.67555  44.79207  1.000 36.52153  ? 234 LYS A CD  1 
ATOM   1808 C CE  . LYS A 1 234 ? -2.27737  -0.85578  44.29067  1.000 41.77290  ? 234 LYS A CE  1 
ATOM   1809 N NZ  . LYS A 1 234 ? -2.71548  0.22772   43.35380  1.000 36.06328  ? 234 LYS A NZ  1 
ATOM   1810 N N   . HIS A 1 235 ? -0.81943  4.32938   45.51624  1.000 16.01696  ? 235 HIS A N   1 
ATOM   1811 C CA  . HIS A 1 235 ? -1.90486  5.14409   46.05884  1.000 19.70636  ? 235 HIS A CA  1 
ATOM   1812 C C   . HIS A 1 235 ? -2.97241  4.22024   46.65660  1.000 16.88255  ? 235 HIS A C   1 
ATOM   1813 O O   . HIS A 1 235 ? -3.42190  3.29892   45.98510  1.000 15.34084  ? 235 HIS A O   1 
ATOM   1814 C CB  . HIS A 1 235 ? -2.46074  6.02134   44.92079  1.000 19.45352  ? 235 HIS A CB  1 
ATOM   1815 C CG  . HIS A 1 235 ? -3.61116  6.89147   45.31667  1.000 24.71923  ? 235 HIS A CG  1 
ATOM   1816 N ND1 . HIS A 1 235 ? -4.82053  6.87382   44.64488  1.000 23.25932  ? 235 HIS A ND1 1 
ATOM   1817 C CD2 . HIS A 1 235 ? -3.73806  7.81547   46.30338  1.000 22.30340  ? 235 HIS A CD2 1 
ATOM   1818 C CE1 . HIS A 1 235 ? -5.64347  7.75013   45.20484  1.000 25.94030  ? 235 HIS A CE1 1 
ATOM   1819 N NE2 . HIS A 1 235 ? -5.01313  8.33715   46.21137  1.000 23.78685  ? 235 HIS A NE2 1 
ATOM   1820 N N   . GLU A 1 236 ? -3.33100  4.40479   47.94002  1.000 14.54048  ? 236 GLU A N   1 
ATOM   1821 C CA  . GLU A 1 236 ? -4.20647  3.46029   48.66016  1.000 19.99609  ? 236 GLU A CA  1 
ATOM   1822 C C   . GLU A 1 236 ? -5.18087  4.24899   49.51850  1.000 23.60857  ? 236 GLU A C   1 
ATOM   1823 O O   . GLU A 1 236 ? -5.05519  4.29566   50.74680  1.000 20.79331  ? 236 GLU A O   1 
ATOM   1824 C CB  . GLU A 1 236 ? -3.42936  2.48262   49.55256  1.000 19.04759  ? 236 GLU A CB  1 
ATOM   1825 C CG  . GLU A 1 236 ? -2.57784  1.42628   48.84429  1.000 20.18579  ? 236 GLU A CG  1 
ATOM   1826 C CD  . GLU A 1 236 ? -3.39543  0.42547   48.02527  1.000 34.14457  ? 236 GLU A CD  1 
ATOM   1827 O OE1 . GLU A 1 236 ? -4.64967  0.43055   48.10152  1.000 30.49478  ? 236 GLU A OE1 1 
ATOM   1828 O OE2 . GLU A 1 236 ? -2.76774  -0.36705  47.29700  1.000 33.54317  ? 236 GLU A OE2 1 
ATOM   1829 N N   . PRO A 1 237 ? -6.17672  4.87599   48.89381  1.000 22.20232  ? 237 PRO A N   1 
ATOM   1830 C CA  . PRO A 1 237 ? -7.05472  5.79284   49.63214  1.000 23.99511  ? 237 PRO A CA  1 
ATOM   1831 C C   . PRO A 1 237 ? -7.86508  5.11738   50.73833  1.000 24.74680  ? 237 PRO A C   1 
ATOM   1832 O O   . PRO A 1 237 ? -8.23751  5.79251   51.69366  1.000 32.34540  ? 237 PRO A O   1 
ATOM   1833 C CB  . PRO A 1 237 ? -7.94266  6.41248   48.53106  1.000 29.36348  ? 237 PRO A CB  1 
ATOM   1834 C CG  . PRO A 1 237 ? -7.75097  5.58653   47.30386  1.000 32.23238  ? 237 PRO A CG  1 
ATOM   1835 C CD  . PRO A 1 237 ? -6.39032  4.89370   47.43433  1.000 24.90261  ? 237 PRO A CD  1 
ATOM   1836 N N   . GLU A 1 238 ? -8.05929  3.80597   50.69860  1.000 25.93261  ? 238 GLU A N   1 
ATOM   1837 C CA  . GLU A 1 238 ? -8.75221  3.07446   51.74575  1.000 32.87016  ? 238 GLU A CA  1 
ATOM   1838 C C   . GLU A 1 238 ? -7.81661  2.52192   52.81927  1.000 31.09044  ? 238 GLU A C   1 
ATOM   1839 O O   . GLU A 1 238 ? -8.27032  1.80888   53.71229  1.000 31.85683  ? 238 GLU A O   1 
ATOM   1840 C CB  . GLU A 1 238 ? -9.54825  1.90685   51.13393  1.000 27.69852  ? 238 GLU A CB  1 
ATOM   1841 C CG  . GLU A 1 238 ? -10.71080 2.30819   50.19950  1.000 53.56770  ? 238 GLU A CG  1 
ATOM   1842 C CD  . GLU A 1 238 ? -10.24769 2.74954   48.80877  1.000 73.83601  ? 238 GLU A CD  1 
ATOM   1843 O OE1 . GLU A 1 238 ? -9.09500  2.42347   48.41856  1.000 78.93601  ? 238 GLU A OE1 1 
ATOM   1844 O OE2 . GLU A 1 238 ? -11.03765 3.42926   48.10580  1.000 72.63601  ? 238 GLU A OE2 1 
ATOM   1845 N N   . LEU A 1 239 ? -6.52034  2.79357   52.75384  1.000 29.26667  ? 239 LEU A N   1 
ATOM   1846 C CA  . LEU A 1 239 ? -5.62685  2.24324   53.76318  1.000 28.62508  ? 239 LEU A CA  1 
ATOM   1847 C C   . LEU A 1 239 ? -5.81269  2.97236   55.09987  1.000 22.23563  ? 239 LEU A C   1 
ATOM   1848 O O   . LEU A 1 239 ? -5.73353  4.19837   55.16683  1.000 26.63044  ? 239 LEU A O   1 
ATOM   1849 C CB  . LEU A 1 239 ? -4.17830  2.35088   53.27988  1.000 23.66358  ? 239 LEU A CB  1 
ATOM   1850 C CG  . LEU A 1 239 ? -3.09347  1.79651   54.19633  1.000 25.19585  ? 239 LEU A CG  1 
ATOM   1851 C CD1 . LEU A 1 239 ? -3.32114  0.32866   54.46976  1.000 25.16518  ? 239 LEU A CD1 1 
ATOM   1852 C CD2 . LEU A 1 239 ? -1.74659  2.00764   53.55385  1.000 19.43801  ? 239 LEU A CD2 1 
ATOM   1853 N N   . ARG A 1 240 ? -6.04439  2.23157   56.17516  1.000 26.89517  ? 240 ARG A N   1 
ATOM   1854 C CA  . ARG A 1 240 ? -6.16210  2.91011   57.45191  1.000 31.08234  ? 240 ARG A CA  1 
ATOM   1855 C C   . ARG A 1 240 ? -4.90553  2.70980   58.28036  1.000 30.08558  ? 240 ARG A C   1 
ATOM   1856 O O   . ARG A 1 240 ? -4.09348  1.81131   58.02142  1.000 28.13077  ? 240 ARG A O   1 
ATOM   1857 C CB  . ARG A 1 240 ? -7.40084  2.45515   58.22440  1.000 41.01299  ? 240 ARG A CB  1 
ATOM   1858 C CG  . ARG A 1 240 ? -7.77728  1.00169   58.11271  1.000 45.13543  ? 240 ARG A CG  1 
ATOM   1859 C CD  . ARG A 1 240 ? -9.31861  0.85346   58.22184  1.000 57.98125  ? 240 ARG A CD  1 
ATOM   1860 N NE  . ARG A 1 240 ? -9.94279  1.92407   59.00560  1.000 73.08413  ? 240 ARG A NE  1 
ATOM   1861 C CZ  . ARG A 1 240 ? -11.25343 2.14511   59.10336  1.000 76.55300  ? 240 ARG A CZ  1 
ATOM   1862 N NH1 . ARG A 1 240 ? -12.13697 1.39189   58.46339  1.000 69.74968  ? 240 ARG A NH1 1 
ATOM   1863 N NH2 . ARG A 1 240 ? -11.68972 3.14788   59.86598  1.000 71.13847  ? 240 ARG A NH2 1 
ATOM   1864 N N   . ARG A 1 241 ? -4.72472  3.60840   59.23803  1.000 25.99131  ? 241 ARG A N   1 
ATOM   1865 C CA  . ARG A 1 241 ? -3.61394  3.49924   60.16171  1.000 25.98009  ? 241 ARG A CA  1 
ATOM   1866 C C   . ARG A 1 241 ? -3.65325  2.14764   60.86181  1.000 26.98927  ? 241 ARG A C   1 
ATOM   1867 O O   . ARG A 1 241 ? -4.71118  1.59155   61.12296  1.000 29.27387  ? 241 ARG A O   1 
ATOM   1868 C CB  . ARG A 1 241 ? -3.64024  4.63886   61.19073  1.000 31.45432  ? 241 ARG A CB  1 
ATOM   1869 C CG  . ARG A 1 241 ? -3.11708  5.98113   60.65371  1.000 35.14191  ? 241 ARG A CG  1 
ATOM   1870 C CD  . ARG A 1 241 ? -2.98069  7.10197   61.72964  1.000 34.20945  ? 241 ARG A CD  1 
ATOM   1871 N NE  . ARG A 1 241 ? -2.52589  8.34620   61.12079  1.000 33.88998  ? 241 ARG A NE  1 
ATOM   1872 C CZ  . ARG A 1 241 ? -3.33116  9.31995   60.69559  1.000 43.95231  ? 241 ARG A CZ  1 
ATOM   1873 N NH1 . ARG A 1 241 ? -4.64108  9.27334   60.88362  1.000 44.01670  ? 241 ARG A NH1 1 
ATOM   1874 N NH2 . ARG A 1 241 ? -2.80886  10.38497  60.09437  1.000 33.32675  ? 241 ARG A NH2 1 
ATOM   1875 N N   . GLU A 1 242 ? -2.47900  1.62586   61.16841  1.000 23.92284  ? 242 GLU A N   1 
ATOM   1876 C CA  . GLU A 1 242 ? -2.33862  0.39319   61.91543  1.000 24.19177  ? 242 GLU A CA  1 
ATOM   1877 C C   . GLU A 1 242 ? -1.42708  0.63614   63.10546  1.000 24.49064  ? 242 GLU A C   1 
ATOM   1878 O O   . GLU A 1 242 ? -0.70046  1.63277   63.16895  1.000 24.51866  ? 242 GLU A O   1 
ATOM   1879 C CB  . GLU A 1 242 ? -1.76475  -0.73679  61.03445  1.000 23.63380  ? 242 GLU A CB  1 
ATOM   1880 C CG  . GLU A 1 242 ? -2.65446  -1.12277  59.85102  1.000 24.05609  ? 242 GLU A CG  1 
ATOM   1881 C CD  . GLU A 1 242 ? -1.87684  -1.97204  58.80137  1.000 28.74991  ? 242 GLU A CD  1 
ATOM   1882 O OE1 . GLU A 1 242 ? -1.10103  -1.38889  58.03487  1.000 24.48434  ? 242 GLU A OE1 1 
ATOM   1883 O OE2 . GLU A 1 242 ? -1.99057  -3.21260  58.80318  1.000 33.40412  ? 242 GLU A OE2 1 
ATOM   1884 N N   . GLU A 1 243 ? -1.45009  -0.30686  64.04735  1.000 19.19757  ? 243 GLU A N   1 
ATOM   1885 C CA  . GLU A 1 243 ? -0.60050  -0.21531  65.22562  1.000 28.38807  ? 243 GLU A CA  1 
ATOM   1886 C C   . GLU A 1 243 ? 0.87669   -0.15075  64.82513  1.000 28.74506  ? 243 GLU A C   1 
ATOM   1887 O O   . GLU A 1 243 ? 1.30877   -0.72795  63.83058  1.000 23.02143  ? 243 GLU A O   1 
ATOM   1888 C CB  . GLU A 1 243 ? -0.87582  -1.41134  66.16973  1.000 26.38294  ? 243 GLU A CB  1 
ATOM   1889 C CG  . GLU A 1 243 ? 0.37268   -2.16961  66.66168  1.000 47.33634  ? 243 GLU A CG  1 
ATOM   1890 C CD  . GLU A 1 243 ? 0.07710   -3.31703  67.65501  1.000 74.07601  ? 243 GLU A CD  1 
ATOM   1891 O OE1 . GLU A 1 243 ? -1.00631  -3.32009  68.30682  1.000 63.41406  ? 243 GLU A OE1 1 
ATOM   1892 O OE2 . GLU A 1 243 ? 0.95046   -4.21738  67.78205  1.000 70.24068  ? 243 GLU A OE2 1 
ATOM   1893 N N   . GLN A 1 244 ? 1.65040   0.58228   65.60163  1.000 24.39754  ? 244 GLN A N   1 
ATOM   1894 C CA  . GLN A 1 244 ? 3.09630   0.68247   65.41318  1.000 32.49614  ? 244 GLN A CA  1 
ATOM   1895 C C   . GLN A 1 244 ? 3.73405   0.31593   66.76584  1.000 38.82134  ? 244 GLN A C   1 
ATOM   1896 O O   . GLN A 1 244 ? 4.69544   -0.43810  66.82762  1.000 47.58321  ? 244 GLN A O   1 
ATOM   1897 C CB  . GLN A 1 244 ? 3.51246   2.11503   64.99503  1.000 28.09866  ? 244 GLN A CB  1 
ATOM   1898 C CG  . GLN A 1 244 ? 4.06778   2.26593   63.62108  1.000 26.84941  ? 244 GLN A CG  1 
ATOM   1899 C CD  . GLN A 1 244 ? 4.61913   3.65675   63.30321  1.000 24.59860  ? 244 GLN A CD  1 
ATOM   1900 O OE1 . GLN A 1 244 ? 5.65356   3.74771   62.65042  1.000 24.57637  ? 244 GLN A OE1 1 
ATOM   1901 N NE2 . GLN A 1 244 ? 3.93277   4.75080   63.75373  1.000 18.04865  ? 244 GLN A NE2 1 
ATOM   1902 N N   . THR B 1 3   ? 45.75173  7.97304   31.91002  1.000 70.09730  ? 3   THR B N   1 
ATOM   1903 C CA  . THR B 1 3   ? 45.92419  6.62949   31.36244  1.000 76.53682  ? 3   THR B CA  1 
ATOM   1904 C C   . THR B 1 3   ? 46.07597  6.70384   29.82041  1.000 66.63855  ? 3   THR B C   1 
ATOM   1905 O O   . THR B 1 3   ? 45.88846  7.76809   29.22261  1.000 56.03148  ? 3   THR B O   1 
ATOM   1906 C CB  . THR B 1 3   ? 44.76678  5.71508   31.81596  1.000 70.34197  ? 3   THR B CB  1 
ATOM   1907 O OG1 . THR B 1 3   ? 44.46510  4.74865   30.80211  1.000 73.61858  ? 3   THR B OG1 1 
ATOM   1908 C CG2 . THR B 1 3   ? 43.53330  6.54305   32.15555  1.000 65.67799  ? 3   THR B CG2 1 
ATOM   1909 N N   . GLU B 1 4   ? 46.44236  5.58241   29.19169  1.000 64.66340  ? 4   GLU B N   1 
ATOM   1910 C CA  . GLU B 1 4   ? 47.19524  5.64018   27.93814  1.000 64.33891  ? 4   GLU B CA  1 
ATOM   1911 C C   . GLU B 1 4   ? 46.39823  6.27347   26.79704  1.000 56.10635  ? 4   GLU B C   1 
ATOM   1912 O O   . GLU B 1 4   ? 46.82602  7.27258   26.21172  1.000 47.24124  ? 4   GLU B O   1 
ATOM   1913 C CB  . GLU B 1 4   ? 47.67551  4.24241   27.54911  1.000 65.01944  ? 4   GLU B CB  1 
ATOM   1914 C CG  . GLU B 1 4   ? 48.79294  3.70072   28.43888  1.000 73.42448  ? 4   GLU B CG  1 
ATOM   1915 C CD  . GLU B 1 4   ? 50.12736  4.40081   28.22173  1.000 83.87227  ? 4   GLU B CD  1 
ATOM   1916 O OE1 . GLU B 1 4   ? 50.29860  5.09983   27.19181  1.000 86.50933  ? 4   GLU B OE1 1 
ATOM   1917 O OE2 . GLU B 1 4   ? 51.01139  4.24177   29.08951  1.000 83.05501  ? 4   GLU B OE2 1 
ATOM   1918 N N   . ALA B 1 5   ? 45.24505  5.70027   26.45114  1.000 48.56828  ? 5   ALA B N   1 
ATOM   1919 C CA  . ALA B 1 5   ? 44.61213  6.04459   25.17844  1.000 41.54638  ? 5   ALA B CA  1 
ATOM   1920 C C   . ALA B 1 5   ? 44.31212  7.54055   25.07659  1.000 40.50885  ? 5   ALA B C   1 
ATOM   1921 O O   . ALA B 1 5   ? 44.61473  8.18659   24.06078  1.000 37.27046  ? 5   ALA B O   1 
ATOM   1922 C CB  . ALA B 1 5   ? 43.34124  5.21113   24.99356  1.000 41.82449  ? 5   ALA B CB  1 
ATOM   1923 N N   . ARG B 1 6   ? 43.74118  8.12041   26.13424  1.000 41.09995  ? 6   ARG B N   1 
ATOM   1924 C CA  . ARG B 1 6   ? 43.24635  9.48795   26.03435  1.000 40.48966  ? 6   ARG B CA  1 
ATOM   1925 C C   . ARG B 1 6   ? 44.38999  10.49207  25.98690  1.000 40.03258  ? 6   ARG B C   1 
ATOM   1926 O O   . ARG B 1 6   ? 44.26906  11.53573  25.33048  1.000 36.79843  ? 6   ARG B O   1 
ATOM   1927 C CB  . ARG B 1 6   ? 42.24255  9.79418   27.17193  1.000 45.79706  ? 6   ARG B CB  1 
ATOM   1928 C CG  . ARG B 1 6   ? 42.65331  9.52496   28.63204  1.000 62.67358  ? 6   ARG B CG  1 
ATOM   1929 C CD  . ARG B 1 6   ? 43.07003  8.06169   28.98194  1.000 71.06601  ? 6   ARG B CD  1 
ATOM   1930 N NE  . ARG B 1 6   ? 42.02077  7.04595   29.04671  1.000 63.03601  ? 6   ARG B NE  1 
ATOM   1931 C CZ  . ARG B 1 6   ? 42.24828  5.73596   29.05673  1.000 55.78196  ? 6   ARG B CZ  1 
ATOM   1932 N NH1 . ARG B 1 6   ? 43.46947  5.25064   28.96792  1.000 59.36129  ? 6   ARG B NH1 1 
ATOM   1933 N NH2 . ARG B 1 6   ? 41.21858  4.88832   29.14577  1.000 55.47026  ? 6   ARG B NH2 1 
ATOM   1934 N N   . GLU B 1 7   ? 45.52890  10.18503  26.61104  1.000 44.18076  ? 7   GLU B N   1 
ATOM   1935 C CA  . GLU B 1 7   ? 46.66597  11.09201  26.44377  1.000 54.02175  ? 7   GLU B CA  1 
ATOM   1936 C C   . GLU B 1 7   ? 47.26172  10.96932  25.04384  1.000 43.22394  ? 7   GLU B C   1 
ATOM   1937 O O   . GLU B 1 7   ? 47.70342  11.96646  24.46181  1.000 41.43680  ? 7   GLU B O   1 
ATOM   1938 C CB  . GLU B 1 7   ? 47.71936  10.85203  27.53510  1.000 58.26219  ? 7   GLU B CB  1 
ATOM   1939 C CG  . GLU B 1 7   ? 48.38253  9.48376   27.56783  1.000 67.81203  ? 7   GLU B CG  1 
ATOM   1940 C CD  . GLU B 1 7   ? 49.50749  9.40893   28.60830  1.000 84.47910  ? 7   GLU B CD  1 
ATOM   1941 O OE1 . GLU B 1 7   ? 49.64393  10.38365  29.38973  1.000 79.81958  ? 7   GLU B OE1 1 
ATOM   1942 O OE2 . GLU B 1 7   ? 50.24922  8.38908   28.63858  1.000 76.55281  ? 7   GLU B OE2 1 
ATOM   1943 N N   . GLU B 1 8   ? 47.21574  9.77296   24.45940  1.000 42.99320  ? 8   GLU B N   1 
ATOM   1944 C CA  . GLU B 1 8   ? 47.65515  9.62227   23.07825  1.000 43.60187  ? 8   GLU B CA  1 
ATOM   1945 C C   . GLU B 1 8   ? 46.72362  10.34220  22.11793  1.000 38.83345  ? 8   GLU B C   1 
ATOM   1946 O O   . GLU B 1 8   ? 47.17296  10.91758  21.12432  1.000 39.21060  ? 8   GLU B O   1 
ATOM   1947 C CB  . GLU B 1 8   ? 47.75260  8.15172   22.73682  1.000 44.51764  ? 8   GLU B CB  1 
ATOM   1948 C CG  . GLU B 1 8   ? 48.63232  7.42000   23.68047  1.000 48.55240  ? 8   GLU B CG  1 
ATOM   1949 C CD  . GLU B 1 8   ? 49.36649  6.32821   22.99167  1.000 60.32037  ? 8   GLU B CD  1 
ATOM   1950 O OE1 . GLU B 1 8   ? 50.45876  6.61864   22.46126  1.000 71.70857  ? 8   GLU B OE1 1 
ATOM   1951 O OE2 . GLU B 1 8   ? 48.83107  5.20001   22.93917  1.000 62.15073  ? 8   GLU B OE2 1 
ATOM   1952 N N   . LEU B 1 9   ? 45.41941  10.33243  22.38912  1.000 37.33865  ? 9   LEU B N   1 
ATOM   1953 C CA  . LEU B 1 9   ? 44.54444  11.14796  21.56337  1.000 34.17113  ? 9   LEU B CA  1 
ATOM   1954 C C   . LEU B 1 9   ? 44.89843  12.60785  21.72423  1.000 33.89377  ? 9   LEU B C   1 
ATOM   1955 O O   . LEU B 1 9   ? 44.89257  13.36571  20.75007  1.000 36.76632  ? 9   LEU B O   1 
ATOM   1956 C CB  . LEU B 1 9   ? 43.06927  10.91726  21.90846  1.000 32.70800  ? 9   LEU B CB  1 
ATOM   1957 C CG  . LEU B 1 9   ? 42.32471  9.80557   21.14913  1.000 36.34970  ? 9   LEU B CG  1 
ATOM   1958 C CD1 . LEU B 1 9   ? 42.33106  10.18712  19.71964  1.000 37.56827  ? 9   LEU B CD1 1 
ATOM   1959 C CD2 . LEU B 1 9   ? 43.01134  8.49279   21.26901  1.000 30.71934  ? 9   LEU B CD2 1 
ATOM   1960 N N   . ARG B 1 10  ? 45.18018  13.02432  22.95904  1.000 42.18704  ? 10  ARG B N   1 
ATOM   1961 C CA  . ARG B 1 10  ? 45.56574  14.40771  23.22322  1.000 42.99231  ? 10  ARG B CA  1 
ATOM   1962 C C   . ARG B 1 10  ? 46.81746  14.77983  22.44225  1.000 39.10513  ? 10  ARG B C   1 
ATOM   1963 O O   . ARG B 1 10  ? 46.84962  15.79170  21.73806  1.000 37.71158  ? 10  ARG B O   1 
ATOM   1964 C CB  . ARG B 1 10  ? 45.78666  14.58914  24.72652  1.000 50.69322  ? 10  ARG B CB  1 
ATOM   1965 C CG  . ARG B 1 10  ? 45.18632  15.84374  25.33231  1.000 61.96088  ? 10  ARG B CG  1 
ATOM   1966 C CD  . ARG B 1 10  ? 45.34055  15.84411  26.85596  1.000 76.49919  ? 10  ARG B CD  1 
ATOM   1967 N NE  . ARG B 1 10  ? 46.58456  15.22781  27.32719  1.000 90.71983  ? 10  ARG B NE  1 
ATOM   1968 C CZ  . ARG B 1 10  ? 47.79994  15.76561  27.23540  1.000 87.09820  ? 10  ARG B CZ  1 
ATOM   1969 N NH1 . ARG B 1 10  ? 48.01253  16.91604  26.60973  1.000 75.85495  ? 10  ARG B NH1 1 
ATOM   1970 N NH2 . ARG B 1 10  ? 48.83424  15.12360  27.77278  1.000 88.06013  ? 10  ARG B NH2 1 
ATOM   1971 N N   . ALA B 1 11  ? 47.84994  13.94798  22.52767  1.000 42.31435  ? 11  ALA B N   1 
ATOM   1972 C CA  . ALA B 1 11  ? 49.10921  14.25247  21.84770  1.000 44.98804  ? 11  ALA B CA  1 
ATOM   1973 C C   . ALA B 1 11  ? 49.01332  14.05662  20.33142  1.000 46.91295  ? 11  ALA B C   1 
ATOM   1974 O O   . ALA B 1 11  ? 49.34593  14.96403  19.55967  1.000 47.24316  ? 11  ALA B O   1 
ATOM   1975 C CB  . ALA B 1 11  ? 50.22550  13.38813  22.42999  1.000 49.03493  ? 11  ALA B CB  1 
ATOM   1976 N N   . ASN B 1 12  ? 48.56632  12.87550  19.88208  1.000 44.40932  ? 12  ASN B N   1 
ATOM   1977 C CA  . ASN B 1 12  ? 48.67740  12.47715  18.47409  1.000 45.14002  ? 12  ASN B CA  1 
ATOM   1978 C C   . ASN B 1 12  ? 47.35792  12.35917  17.71829  1.000 43.90995  ? 12  ASN B C   1 
ATOM   1979 O O   . ASN B 1 12  ? 47.39256  12.07786  16.51580  1.000 42.94658  ? 12  ASN B O   1 
ATOM   1980 C CB  . ASN B 1 12  ? 49.39910  11.12719  18.35403  1.000 44.26210  ? 12  ASN B CB  1 
ATOM   1981 C CG  . ASN B 1 12  ? 50.54682  10.99796  19.31945  1.000 50.41746  ? 12  ASN B CG  1 
ATOM   1982 O OD1 . ASN B 1 12  ? 50.66329  10.00976  20.04756  1.000 54.81577  ? 12  ASN B OD1 1 
ATOM   1983 N ND2 . ASN B 1 12  ? 51.39800  12.00009  19.33921  1.000 41.92726  ? 12  ASN B ND2 1 
ATOM   1984 N N   . GLY B 1 13  ? 46.20184  12.51088  18.37398  1.000 36.23872  ? 13  GLY B N   1 
ATOM   1985 C CA  . GLY B 1 13  ? 44.95535  12.47959  17.63446  1.000 34.01937  ? 13  GLY B CA  1 
ATOM   1986 C C   . GLY B 1 13  ? 44.43448  11.08988  17.29688  1.000 30.95484  ? 13  GLY B C   1 
ATOM   1987 O O   . GLY B 1 13  ? 43.35414  10.98059  16.69449  1.000 31.65848  ? 13  GLY B O   1 
ATOM   1988 N N   . TYR B 1 14  ? 45.14025  10.03390  17.69735  1.000 32.68335  ? 14  TYR B N   1 
ATOM   1989 C CA  . TYR B 1 14  ? 44.70869  8.66217   17.47730  1.000 31.08591  ? 14  TYR B CA  1 
ATOM   1990 C C   . TYR B 1 14  ? 45.39313  7.80992   18.51943  1.000 34.33790  ? 14  TYR B C   1 
ATOM   1991 O O   . TYR B 1 14  ? 46.37276  8.23729   19.13136  1.000 35.32779  ? 14  TYR B O   1 
ATOM   1992 C CB  . TYR B 1 14  ? 45.04724  8.17689   16.05300  1.000 34.13354  ? 14  TYR B CB  1 
ATOM   1993 C CG  . TYR B 1 14  ? 46.55621  8.00930   15.78610  1.000 43.30497  ? 14  TYR B CG  1 
ATOM   1994 C CD1 . TYR B 1 14  ? 47.38377  9.12453   15.59630  1.000 41.13268  ? 14  TYR B CD1 1 
ATOM   1995 C CD2 . TYR B 1 14  ? 47.14601  6.74138   15.71838  1.000 39.47302  ? 14  TYR B CD2 1 
ATOM   1996 C CE1 . TYR B 1 14  ? 48.74711  8.98524   15.34819  1.000 39.99940  ? 14  TYR B CE1 1 
ATOM   1997 C CE2 . TYR B 1 14  ? 48.52089  6.59236   15.47952  1.000 42.58114  ? 14  TYR B CE2 1 
ATOM   1998 C CZ  . TYR B 1 14  ? 49.30580  7.71881   15.29727  1.000 45.39079  ? 14  TYR B CZ  1 
ATOM   1999 O OH  . TYR B 1 14  ? 50.65397  7.58236   15.05789  1.000 67.03164  ? 14  TYR B OH  1 
ATOM   2000 N N   . SER B 1 15  ? 44.88203  6.59109   18.69931  1.000 32.52478  ? 15  SER B N   1 
ATOM   2001 C CA  . SER B 1 15  ? 45.52494  5.62047   19.56937  1.000 32.03952  ? 15  SER B CA  1 
ATOM   2002 C C   . SER B 1 15  ? 45.09900  4.22037   19.13912  1.000 39.75582  ? 15  SER B C   1 
ATOM   2003 O O   . SER B 1 15  ? 43.94753  4.00548   18.73073  1.000 36.39843  ? 15  SER B O   1 
ATOM   2004 C CB  . SER B 1 15  ? 45.17577  5.89989   21.04464  1.000 34.90079  ? 15  SER B CB  1 
ATOM   2005 O OG  . SER B 1 15  ? 45.37947  4.78450   21.89218  1.000 29.45221  ? 15  SER B OG  1 
ATOM   2006 N N   . LEU B 1 16  ? 46.03827  3.27919   19.23568  1.000 32.92903  ? 16  LEU B N   1 
ATOM   2007 C CA  . LEU B 1 16  ? 45.88721  1.92405   18.74382  1.000 33.19579  ? 16  LEU B CA  1 
ATOM   2008 C C   . LEU B 1 16  ? 45.66778  0.99961   19.91999  1.000 34.61741  ? 16  LEU B C   1 
ATOM   2009 O O   . LEU B 1 16  ? 46.34340  1.13201   20.93647  1.000 34.20351  ? 16  LEU B O   1 
ATOM   2010 C CB  . LEU B 1 16  ? 47.14847  1.47318   18.00573  1.000 39.96021  ? 16  LEU B CB  1 
ATOM   2011 C CG  . LEU B 1 16  ? 47.23894  1.39390   16.49789  1.000 49.86020  ? 16  LEU B CG  1 
ATOM   2012 C CD1 . LEU B 1 16  ? 46.39949  0.21579   16.00239  1.000 49.58328  ? 16  LEU B CD1 1 
ATOM   2013 C CD2 . LEU B 1 16  ? 46.77023  2.71412   15.93219  1.000 45.29038  ? 16  LEU B CD2 1 
ATOM   2014 N N   . LEU B 1 17  ? 44.75926  0.03635   19.77702  1.000 29.38381  ? 17  LEU B N   1 
ATOM   2015 C CA  . LEU B 1 17  ? 44.53750  -0.96648  20.81767  1.000 29.55626  ? 17  LEU B CA  1 
ATOM   2016 C C   . LEU B 1 17  ? 44.41571  -2.31002  20.12839  1.000 31.68130  ? 17  LEU B C   1 
ATOM   2017 O O   . LEU B 1 17  ? 43.34144  -2.63529  19.60085  1.000 32.04472  ? 17  LEU B O   1 
ATOM   2018 C CB  . LEU B 1 17  ? 43.28779  -0.65612  21.63968  1.000 32.41043  ? 17  LEU B CB  1 
ATOM   2019 C CG  . LEU B 1 17  ? 43.10956  -1.10369  23.09041  1.000 43.38009  ? 17  LEU B CG  1 
ATOM   2020 C CD1 . LEU B 1 17  ? 41.64779  -0.99765  23.45769  1.000 34.53754  ? 17  LEU B CD1 1 
ATOM   2021 C CD2 . LEU B 1 17  ? 43.63687  -2.49565  23.36648  1.000 46.05329  ? 17  LEU B CD2 1 
ATOM   2022 N N   . PRO B 1 18  ? 45.48541  -3.10702  20.08427  1.000 34.77154  ? 18  PRO B N   1 
ATOM   2023 C CA  . PRO B 1 18  ? 45.38569  -4.41497  19.43055  1.000 33.11712  ? 18  PRO B CA  1 
ATOM   2024 C C   . PRO B 1 18  ? 44.60167  -5.39173  20.28729  1.000 40.79647  ? 18  PRO B C   1 
ATOM   2025 O O   . PRO B 1 18  ? 44.54915  -5.27994  21.51635  1.000 39.54230  ? 18  PRO B O   1 
ATOM   2026 C CB  . PRO B 1 18  ? 46.84926  -4.85577  19.27318  1.000 46.03247  ? 18  PRO B CB  1 
ATOM   2027 C CG  . PRO B 1 18  ? 47.62211  -4.00773  20.23399  1.000 36.92367  ? 18  PRO B CG  1 
ATOM   2028 C CD  . PRO B 1 18  ? 46.88524  -2.71592  20.32672  1.000 40.08774  ? 18  PRO B CD  1 
ATOM   2029 N N   . ALA B 1 19  ? 43.97773  -6.36143  19.61479  1.000 33.59407  ? 19  ALA B N   1 
ATOM   2030 C CA  . ALA B 1 19  ? 43.16890  -7.34519  20.33020  1.000 40.64073  ? 19  ALA B CA  1 
ATOM   2031 C C   . ALA B 1 19  ? 43.98560  -8.12914  21.34588  1.000 46.25889  ? 19  ALA B C   1 
ATOM   2032 O O   . ALA B 1 19  ? 43.44258  -8.58185  22.35746  1.000 48.16055  ? 19  ALA B O   1 
ATOM   2033 C CB  . ALA B 1 19  ? 42.51811  -8.30756  19.34113  1.000 37.57158  ? 19  ALA B CB  1 
ATOM   2034 N N   . ASP B 1 20  ? 45.28432  -8.31684  21.09460  1.000 54.23979  ? 20  ASP B N   1 
ATOM   2035 C CA  . ASP B 1 20  ? 46.08967  -9.11889  22.01077  1.000 58.67477  ? 20  ASP B CA  1 
ATOM   2036 C C   . ASP B 1 20  ? 46.31917  -8.39944  23.33081  1.000 62.03930  ? 20  ASP B C   1 
ATOM   2037 O O   . ASP B 1 20  ? 46.57932  -9.05827  24.34402  1.000 66.53173  ? 20  ASP B O   1 
ATOM   2038 C CB  . ASP B 1 20  ? 47.42080  -9.50790  21.35685  1.000 56.21315  ? 20  ASP B CB  1 
ATOM   2039 C CG  . ASP B 1 20  ? 48.27208  -8.30983  21.00285  1.000 61.73155  ? 20  ASP B CG  1 
ATOM   2040 O OD1 . ASP B 1 20  ? 48.84133  -7.69598  21.92799  1.000 71.63758  ? 20  ASP B OD1 1 
ATOM   2041 O OD2 . ASP B 1 20  ? 48.38167  -7.98116  19.80285  1.000 66.18002  ? 20  ASP B OD2 1 
ATOM   2042 N N   . ARG B 1 21  ? 46.19748  -7.06799  23.34297  1.000 54.99346  ? 21  ARG B N   1 
ATOM   2043 C CA  . ARG B 1 21  ? 46.24112  -6.30103  24.57767  1.000 60.05640  ? 21  ARG B CA  1 
ATOM   2044 C C   . ARG B 1 21  ? 44.95035  -6.39647  25.38806  1.000 60.50165  ? 21  ARG B C   1 
ATOM   2045 O O   . ARG B 1 21  ? 44.91111  -5.88635  26.50874  1.000 63.51160  ? 21  ARG B O   1 
ATOM   2046 C CB  . ARG B 1 21  ? 46.55813  -4.83810  24.26017  1.000 59.48477  ? 21  ARG B CB  1 
ATOM   2047 C CG  . ARG B 1 21  ? 47.46533  -4.16030  25.27219  1.000 61.30629  ? 21  ARG B CG  1 
ATOM   2048 C CD  . ARG B 1 21  ? 47.92170  -2.79770  24.77981  1.000 62.76446  ? 21  ARG B CD  1 
ATOM   2049 N NE  . ARG B 1 21  ? 48.83317  -2.91579  23.64566  1.000 71.72129  ? 21  ARG B NE  1 
ATOM   2050 C CZ  . ARG B 1 21  ? 49.31803  -1.88769  22.95690  1.000 77.95637  ? 21  ARG B CZ  1 
ATOM   2051 N NH1 . ARG B 1 21  ? 48.96872  -0.64051  23.23796  1.000 75.06413  ? 21  ARG B NH1 1 
ATOM   2052 N NH2 . ARG B 1 21  ? 50.17257  -2.11583  21.95873  1.000 65.47907  ? 21  ARG B NH2 1 
ATOM   2053 N N   . LEU B 1 22  ? 43.91104  -7.05599  24.87926  1.000 58.66585  ? 22  LEU B N   1 
ATOM   2054 C CA  . LEU B 1 22  ? 42.61914  -7.11513  25.55488  1.000 64.38764  ? 22  LEU B CA  1 
ATOM   2055 C C   . LEU B 1 22  ? 42.40441  -8.49690  26.16738  1.000 65.01834  ? 22  LEU B C   1 
ATOM   2056 O O   . LEU B 1 22  ? 42.79470  -9.51402  25.58418  1.000 61.07710  ? 22  LEU B O   1 
ATOM   2057 C CB  . LEU B 1 22  ? 41.48382  -6.77067  24.58134  1.000 64.08984  ? 22  LEU B CB  1 
ATOM   2058 C CG  . LEU B 1 22  ? 40.07359  -6.47712  25.10854  1.000 75.80513  ? 22  LEU B CG  1 
ATOM   2059 C CD1 . LEU B 1 22  ? 39.21201  -7.73963  25.16569  1.000 73.03944  ? 22  LEU B CD1 1 
ATOM   2060 C CD2 . LEU B 1 22  ? 40.12519  -5.80169  26.47994  1.000 75.61199  ? 22  LEU B CD2 1 
ATOM   2061 N N   . VAL B 1 23  ? 41.79762  -8.51883  27.35616  1.000 63.47358  ? 23  VAL B N   1 
ATOM   2062 C CA  . VAL B 1 23  ? 41.51223  -9.75285  28.08133  1.000 63.37284  ? 23  VAL B CA  1 
ATOM   2063 C C   . VAL B 1 23  ? 40.14184  -10.25682 27.64880  1.000 63.44067  ? 23  VAL B C   1 
ATOM   2064 O O   . VAL B 1 23  ? 39.12276  -9.59802  27.88303  1.000 67.67617  ? 23  VAL B O   1 
ATOM   2065 C CB  . VAL B 1 23  ? 41.55509  -9.53944  29.60460  1.000 59.84218  ? 23  VAL B CB  1 
ATOM   2066 C CG1 . VAL B 1 23  ? 41.28925  -10.84794 30.30910  1.000 62.83887  ? 23  VAL B CG1 1 
ATOM   2067 C CG2 . VAL B 1 23  ? 42.89097  -8.95070  30.05815  1.000 59.86477  ? 23  VAL B CG2 1 
ATOM   2068 N N   . ILE B 1 24  ? 40.10874  -11.43467 27.04120  1.000 57.95827  ? 24  ILE B N   1 
ATOM   2069 C CA  . ILE B 1 24  ? 38.88381  -11.97928 26.47743  1.000 65.63454  ? 24  ILE B CA  1 
ATOM   2070 C C   . ILE B 1 24  ? 38.57637  -13.33172 27.11426  1.000 68.61289  ? 24  ILE B C   1 
ATOM   2071 O O   . ILE B 1 24  ? 39.37988  -14.26271 27.01272  1.000 72.78798  ? 24  ILE B O   1 
ATOM   2072 C CB  . ILE B 1 24  ? 39.02166  -12.08025 24.95797  1.000 64.81918  ? 24  ILE B CB  1 
ATOM   2073 N N   . ASP B 1 25  ? 37.41444  -13.43098 27.77133  1.000 63.72064  ? 25  ASP B N   1 
ATOM   2074 C CA  . ASP B 1 25  ? 36.93146  -14.64015 28.42591  1.000 61.78614  ? 25  ASP B CA  1 
ATOM   2075 C C   . ASP B 1 25  ? 35.97803  -15.39309 27.49038  1.000 66.55413  ? 25  ASP B C   1 
ATOM   2076 O O   . ASP B 1 25  ? 35.72317  -14.97402 26.35872  1.000 60.18977  ? 25  ASP B O   1 
ATOM   2077 C CB  . ASP B 1 25  ? 36.23540  -14.29714 29.75132  1.000 63.61921  ? 25  ASP B CB  1 
ATOM   2078 C CG  . ASP B 1 25  ? 35.04992  -13.34931 29.56348  1.000 72.93022  ? 25  ASP B CG  1 
ATOM   2079 O OD1 . ASP B 1 25  ? 35.26827  -12.20345 29.08639  1.000 71.79911  ? 25  ASP B OD1 1 
ATOM   2080 O OD2 . ASP B 1 25  ? 33.90340  -13.75668 29.86857  1.000 67.36609  ? 25  ASP B OD2 1 
ATOM   2081 N N   . ALA B 1 26  ? 35.41169  -16.50525 27.98140  1.000 57.64907  ? 26  ALA B N   1 
ATOM   2082 C CA  . ALA B 1 26  ? 34.56801  -17.34390 27.12395  1.000 61.23549  ? 26  ALA B CA  1 
ATOM   2083 C C   . ALA B 1 26  ? 33.24037  -16.66699 26.77232  1.000 57.44005  ? 26  ALA B C   1 
ATOM   2084 O O   . ALA B 1 26  ? 32.77027  -16.77739 25.62999  1.000 47.69055  ? 26  ALA B O   1 
ATOM   2085 C CB  . ALA B 1 26  ? 34.30999  -18.69581 27.78961  1.000 58.41274  ? 26  ALA B CB  1 
ATOM   2086 N N   . GLU B 1 27  ? 32.60450  -15.99946 27.74669  1.000 54.58157  ? 27  GLU B N   1 
ATOM   2087 C CA  . GLU B 1 27  ? 31.36364  -15.27282 27.48215  1.000 58.81279  ? 27  GLU B CA  1 
ATOM   2088 C C   . GLU B 1 27  ? 31.57803  -14.19399 26.42033  1.000 50.48975  ? 27  GLU B C   1 
ATOM   2089 O O   . GLU B 1 27  ? 30.80253  -14.07785 25.46145  1.000 48.13718  ? 27  GLU B O   1 
ATOM   2090 C CB  . GLU B 1 27  ? 30.83234  -14.65684 28.78477  1.000 63.50360  ? 27  GLU B CB  1 
ATOM   2091 C CG  . GLU B 1 27  ? 29.69296  -13.62228 28.59993  1.000 68.15748  ? 27  GLU B CG  1 
ATOM   2092 C CD  . GLU B 1 27  ? 29.65821  -12.53010 29.69421  1.000 74.98711  ? 27  GLU B CD  1 
ATOM   2093 O OE1 . GLU B 1 27  ? 30.50598  -12.55535 30.62303  1.000 75.72407  ? 27  GLU B OE1 1 
ATOM   2094 O OE2 . GLU B 1 27  ? 28.78476  -11.63437 29.61410  1.000 62.74878  ? 27  GLU B OE2 1 
ATOM   2095 N N   . LEU B 1 28  ? 32.62931  -13.39238 26.58660  1.000 46.84091  ? 28  LEU B N   1 
ATOM   2096 C CA  . LEU B 1 28  ? 32.90340  -12.30620 25.65936  1.000 44.37342  ? 28  LEU B CA  1 
ATOM   2097 C C   . LEU B 1 28  ? 33.20816  -12.84459 24.27178  1.000 47.58339  ? 28  LEU B C   1 
ATOM   2098 O O   . LEU B 1 28  ? 32.69161  -12.32464 23.26633  1.000 30.88575  ? 28  LEU B O   1 
ATOM   2099 C CB  . LEU B 1 28  ? 34.06461  -11.45904 26.17357  1.000 44.33288  ? 28  LEU B CB  1 
ATOM   2100 C CG  . LEU B 1 28  ? 34.50256  -10.33533 25.24439  1.000 41.95075  ? 28  LEU B CG  1 
ATOM   2101 C CD1 . LEU B 1 28  ? 33.33471  -9.38185  24.96274  1.000 37.44300  ? 28  LEU B CD1 1 
ATOM   2102 C CD2 . LEU B 1 28  ? 35.68513  -9.59177  25.80854  1.000 51.13500  ? 28  LEU B CD2 1 
ATOM   2103 N N   . ARG B 1 29  ? 34.04256  -13.89704 24.20686  1.000 42.33556  ? 29  ARG B N   1 
ATOM   2104 C CA  . ARG B 1 29  ? 34.38802  -14.53630 22.93728  1.000 45.54771  ? 29  ARG B CA  1 
ATOM   2105 C C   . ARG B 1 29  ? 33.12694  -14.91161 22.18868  1.000 45.87923  ? 29  ARG B C   1 
ATOM   2106 O O   . ARG B 1 29  ? 33.00771  -14.68968 20.97463  1.000 38.18582  ? 29  ARG B O   1 
ATOM   2107 C CB  . ARG B 1 29  ? 35.24364  -15.79425 23.18466  1.000 60.03070  ? 29  ARG B CB  1 
ATOM   2108 C CG  . ARG B 1 29  ? 36.66990  -15.81109 22.57729  1.000 79.63180  ? 29  ARG B CG  1 
ATOM   2109 C CD  . ARG B 1 29  ? 37.70916  -16.62561 23.41767  1.000 79.75601  ? 29  ARG B CD  1 
ATOM   2110 N NE  . ARG B 1 29  ? 37.67609  -18.06683 23.18600  1.000 89.82900  ? 29  ARG B NE  1 
ATOM   2111 C CZ  . ARG B 1 29  ? 37.20427  -18.96024 24.04714  1.000 95.94413  ? 29  ARG B CZ  1 
ATOM   2112 N NH1 . ARG B 1 29  ? 36.72408  -18.59800 25.22416  1.000 86.76383  ? 29  ARG B NH1 1 
ATOM   2113 N NH2 . ARG B 1 29  ? 37.21953  -20.25141 23.71977  1.000 105.83472 ? 29  ARG B NH2 1 
ATOM   2114 N N   . GLN B 1 30  ? 32.16341  -15.48596 22.91079  1.000 42.63582  ? 30  GLN B N   1 
ATOM   2115 C CA  . GLN B 1 30  ? 30.91931  -15.87081 22.26673  1.000 44.77067  ? 30  GLN B CA  1 
ATOM   2116 C C   . GLN B 1 30  ? 30.16143  -14.64339 21.76398  1.000 40.63974  ? 30  GLN B C   1 
ATOM   2117 O O   . GLN B 1 30  ? 29.60713  -14.67184 20.66250  1.000 35.06813  ? 30  GLN B O   1 
ATOM   2118 C CB  . GLN B 1 30  ? 30.07172  -16.69966 23.22492  1.000 44.34603  ? 30  GLN B CB  1 
ATOM   2119 C CG  . GLN B 1 30  ? 28.83401  -17.31077 22.58959  1.000 51.73574  ? 30  GLN B CG  1 
ATOM   2120 C CD  . GLN B 1 30  ? 29.15980  -18.26657 21.44656  1.000 62.36866  ? 30  GLN B CD  1 
ATOM   2121 O OE1 . GLN B 1 30  ? 30.23717  -18.86490 21.40464  1.000 61.31621  ? 30  GLN B OE1 1 
ATOM   2122 N NE2 . GLN B 1 30  ? 28.22317  -18.40708 20.50760  1.000 61.35302  ? 30  GLN B NE2 1 
ATOM   2123 N N   . HIS B 1 31  ? 30.15626  -13.54435 22.53877  1.000 38.60843  ? 31  HIS B N   1 
ATOM   2124 C CA  . HIS B 1 31  ? 29.44301  -12.33982 22.10851  1.000 31.11245  ? 31  HIS B CA  1 
ATOM   2125 C C   . HIS B 1 31  ? 30.09499  -11.70654 20.87979  1.000 27.69264  ? 31  HIS B C   1 
ATOM   2126 O O   . HIS B 1 31  ? 29.39684  -11.22337 19.98403  1.000 26.65181  ? 31  HIS B O   1 
ATOM   2127 C CB  . HIS B 1 31  ? 29.38531  -11.30569 23.23058  1.000 30.50102  ? 31  HIS B CB  1 
ATOM   2128 C CG  . HIS B 1 31  ? 28.41061  -11.62437 24.32345  1.000 40.33274  ? 31  HIS B CG  1 
ATOM   2129 N ND1 . HIS B 1 31  ? 27.14908  -12.12612 24.08151  1.000 50.08440  ? 31  HIS B ND1 1 
ATOM   2130 C CD2 . HIS B 1 31  ? 28.51254  -11.49703 25.66995  1.000 45.60320  ? 31  HIS B CD2 1 
ATOM   2131 C CE1 . HIS B 1 31  ? 26.51801  -12.30296 25.23076  1.000 47.04969  ? 31  HIS B CE1 1 
ATOM   2132 N NE2 . HIS B 1 31  ? 27.32435  -11.93171 26.20961  1.000 47.82201  ? 31  HIS B NE2 1 
ATOM   2133 N N   . VAL B 1 32  ? 31.42565  -11.65595 20.84663  1.000 26.68096  ? 32  VAL B N   1 
ATOM   2134 C CA  . VAL B 1 32  ? 32.12899  -11.12875 19.67866  1.000 26.84325  ? 32  VAL B CA  1 
ATOM   2135 C C   . VAL B 1 32  ? 31.78377  -11.94117 18.43460  1.000 28.53547  ? 32  VAL B C   1 
ATOM   2136 O O   . VAL B 1 32  ? 31.50269  -11.39098 17.36651  1.000 26.82220  ? 32  VAL B O   1 
ATOM   2137 C CB  . VAL B 1 32  ? 33.64563  -11.12878 19.92937  1.000 31.62028  ? 32  VAL B CB  1 
ATOM   2138 C CG1 . VAL B 1 32  ? 34.39665  -10.78972 18.63667  1.000 31.11098  ? 32  VAL B CG1 1 
ATOM   2139 C CG2 . VAL B 1 32  ? 34.00620  -10.15199 21.02675  1.000 26.07773  ? 32  VAL B CG2 1 
ATOM   2140 N N   . LYS B 1 33  ? 31.82610  -13.26564 18.54832  1.000 31.38726  ? 33  LYS B N   1 
ATOM   2141 C CA  . LYS B 1 33  ? 31.52273  -14.09265 17.38608  1.000 33.59196  ? 33  LYS B CA  1 
ATOM   2142 C C   . LYS B 1 33  ? 30.10848  -13.83658 16.87808  1.000 29.52522  ? 33  LYS B C   1 
ATOM   2143 O O   . LYS B 1 33  ? 29.88261  -13.71442 15.66315  1.000 28.94212  ? 33  LYS B O   1 
ATOM   2144 C CB  . LYS B 1 33  ? 31.71041  -15.56905 17.73730  1.000 37.68740  ? 33  LYS B CB  1 
ATOM   2145 C CG  . LYS B 1 33  ? 32.91331  -16.18385 17.06826  1.000 53.83776  ? 33  LYS B CG  1 
ATOM   2146 C CD  . LYS B 1 33  ? 34.19310  -15.77892 17.77175  1.000 58.61067  ? 33  LYS B CD  1 
ATOM   2147 C CE  . LYS B 1 33  ? 34.42286  -16.65351 18.99863  1.000 77.75601  ? 33  LYS B CE  1 
ATOM   2148 N NZ  . LYS B 1 33  ? 35.58133  -16.19011 19.81191  1.000 77.17709  ? 33  LYS B NZ  1 
ATOM   2149 N N   . GLU B 1 34  ? 29.13622  -13.76996 17.79130  1.000 26.31712  ? 34  GLU B N   1 
ATOM   2150 C CA  . GLU B 1 34  ? 27.76765  -13.52671 17.36113  1.000 30.21569  ? 34  GLU B CA  1 
ATOM   2151 C C   . GLU B 1 34  ? 27.60313  -12.11612 16.78565  1.000 29.86423  ? 34  GLU B C   1 
ATOM   2152 O O   . GLU B 1 34  ? 26.78375  -11.89922 15.88150  1.000 32.96355  ? 34  GLU B O   1 
ATOM   2153 C CB  . GLU B 1 34  ? 26.81845  -13.73546 18.53647  1.000 29.31746  ? 34  GLU B CB  1 
ATOM   2154 C CG  . GLU B 1 34  ? 26.95058  -15.09448 19.22269  1.000 38.91557  ? 34  GLU B CG  1 
ATOM   2155 C CD  . GLU B 1 34  ? 26.11634  -15.18197 20.49814  1.000 56.40601  ? 34  GLU B CD  1 
ATOM   2156 O OE1 . GLU B 1 34  ? 25.51379  -14.14356 20.88058  1.000 51.78390  ? 34  GLU B OE1 1 
ATOM   2157 O OE2 . GLU B 1 34  ? 26.06640  -16.27674 21.11463  1.000 60.43486  ? 34  GLU B OE2 1 
ATOM   2158 N N   . LEU B 1 35  ? 28.30100  -11.12344 17.35535  1.000 29.58349  ? 35  LEU B N   1 
ATOM   2159 C CA  . LEU B 1 35  ? 28.27842  -9.78737  16.75968  1.000 25.67269  ? 35  LEU B CA  1 
ATOM   2160 C C   . LEU B 1 35  ? 28.88653  -9.82401  15.36310  1.000 23.48091  ? 35  LEU B C   1 
ATOM   2161 O O   . LEU B 1 35  ? 28.28357  -9.36079  14.38984  1.000 21.74800  ? 35  LEU B O   1 
ATOM   2162 C CB  . LEU B 1 35  ? 29.03906  -8.81091  17.66086  1.000 20.34535  ? 35  LEU B CB  1 
ATOM   2163 C CG  . LEU B 1 35  ? 29.21703  -7.37964  17.16891  1.000 22.48466  ? 35  LEU B CG  1 
ATOM   2164 C CD1 . LEU B 1 35  ? 27.85328  -6.79707  16.75175  1.000 20.51089  ? 35  LEU B CD1 1 
ATOM   2165 C CD2 . LEU B 1 35  ? 29.83992  -6.53075  18.28885  1.000 19.50604  ? 35  LEU B CD2 1 
ATOM   2166 N N   . ALA B 1 36  ? 30.08435  -10.40262 15.24536  1.000 24.41987  ? 36  ALA B N   1 
ATOM   2167 C CA  . ALA B 1 36  ? 30.77864  -10.40104 13.96198  1.000 28.47531  ? 36  ALA B CA  1 
ATOM   2168 C C   . ALA B 1 36  ? 30.00471  -11.17017 12.89387  1.000 25.76020  ? 36  ALA B C   1 
ATOM   2169 O O   . ALA B 1 36  ? 30.06515  -10.80939 11.71611  1.000 27.23393  ? 36  ALA B O   1 
ATOM   2170 C CB  . ALA B 1 36  ? 32.18565  -10.97321 14.14506  1.000 27.20716  ? 36  ALA B CB  1 
ATOM   2171 N N   . ALA B 1 37  ? 29.23413  -12.19699 13.29176  1.000 27.09618  ? 37  ALA B N   1 
ATOM   2172 C CA  . ALA B 1 37  ? 28.42198  -12.96666 12.34630  1.000 23.96251  ? 37  ALA B CA  1 
ATOM   2173 C C   . ALA B 1 37  ? 27.37597  -12.10084 11.64430  1.000 31.30700  ? 37  ALA B C   1 
ATOM   2174 O O   . ALA B 1 37  ? 26.96586  -12.40532 10.51369  1.000 26.71076  ? 37  ALA B O   1 
ATOM   2175 C CB  . ALA B 1 37  ? 27.75160  -14.12923 13.08759  1.000 28.04123  ? 37  ALA B CB  1 
ATOM   2176 N N   . GLU B 1 38  ? 26.94491  -11.00390 12.27834  1.000 28.39207  ? 38  GLU B N   1 
ATOM   2177 C CA  . GLU B 1 38  ? 25.99666  -10.10479 11.63103  1.000 23.93708  ? 38  GLU B CA  1 
ATOM   2178 C C   . GLU B 1 38  ? 26.51284  -9.51068  10.32683  1.000 27.06141  ? 38  GLU B C   1 
ATOM   2179 O O   . GLU B 1 38  ? 25.69959  -9.05110  9.52185   1.000 26.59863  ? 38  GLU B O   1 
ATOM   2180 C CB  . GLU B 1 38  ? 25.62757  -8.94174  12.56273  1.000 25.81515  ? 38  GLU B CB  1 
ATOM   2181 C CG  . GLU B 1 38  ? 25.00248  -9.37609  13.87155  1.000 29.18179  ? 38  GLU B CG  1 
ATOM   2182 C CD  . GLU B 1 38  ? 23.62504  -9.99890  13.67035  1.000 36.14210  ? 38  GLU B CD  1 
ATOM   2183 O OE1 . GLU B 1 38  ? 22.97162  -9.77158  12.60280  1.000 33.44769  ? 38  GLU B OE1 1 
ATOM   2184 O OE2 . GLU B 1 38  ? 23.20011  -10.71265 14.60575  1.000 38.14949  ? 38  GLU B OE2 1 
ATOM   2185 N N   . TRP B 1 39  ? 27.82886  -9.44218  10.11847  1.000 24.50540  ? 39  TRP B N   1 
ATOM   2186 C CA  . TRP B 1 39  ? 28.29469  -8.87227  8.85923   1.000 27.06100  ? 39  TRP B CA  1 
ATOM   2187 C C   . TRP B 1 39  ? 27.96402  -9.75598  7.64998   1.000 29.61875  ? 39  TRP B C   1 
ATOM   2188 O O   . TRP B 1 39  ? 28.18162  -9.32786  6.50766   1.000 25.25623  ? 39  TRP B O   1 
ATOM   2189 C CB  . TRP B 1 39  ? 29.80135  -8.60053  8.91714   1.000 23.92959  ? 39  TRP B CB  1 
ATOM   2190 C CG  . TRP B 1 39  ? 30.14769  -7.24047  9.50060   1.000 23.61367  ? 39  TRP B CG  1 
ATOM   2191 C CD1 . TRP B 1 39  ? 30.68137  -6.16688  8.83735   1.000 22.35295  ? 39  TRP B CD1 1 
ATOM   2192 C CD2 . TRP B 1 39  ? 29.91839  -6.80108  10.85050  1.000 24.66100  ? 39  TRP B CD2 1 
ATOM   2193 N NE1 . TRP B 1 39  ? 30.82920  -5.09749  9.69401   1.000 21.28344  ? 39  TRP B NE1 1 
ATOM   2194 C CE2 . TRP B 1 39  ? 30.36286  -5.45763  10.93354  1.000 22.60213  ? 39  TRP B CE2 1 
ATOM   2195 C CE3 . TRP B 1 39  ? 29.41372  -7.42269  12.00286  1.000 20.38991  ? 39  TRP B CE3 1 
ATOM   2196 C CZ2 . TRP B 1 39  ? 30.29368  -4.71039  12.11680  1.000 21.16238  ? 39  TRP B CZ2 1 
ATOM   2197 C CZ3 . TRP B 1 39  ? 29.33561  -6.66622  13.18724  1.000 22.14548  ? 39  TRP B CZ3 1 
ATOM   2198 C CH2 . TRP B 1 39  ? 29.78101  -5.33733  13.22632  1.000 23.47221  ? 39  TRP B CH2 1 
ATOM   2199 N N   . GLU B 1 40  ? 27.45072  -10.97019 7.86553   1.000 31.05329  ? 40  GLU B N   1 
ATOM   2200 C CA  . GLU B 1 40  ? 27.02715  -11.81110 6.74451   1.000 33.62470  ? 40  GLU B CA  1 
ATOM   2201 C C   . GLU B 1 40  ? 25.63802  -11.45469 6.23115   1.000 37.15281  ? 40  GLU B C   1 
ATOM   2202 O O   . GLU B 1 40  ? 25.26978  -11.87560 5.12674   1.000 41.47730  ? 40  GLU B O   1 
ATOM   2203 C CB  . GLU B 1 40  ? 27.09457  -13.27960 7.15126   1.000 28.10505  ? 40  GLU B CB  1 
ATOM   2204 C CG  . GLU B 1 40  ? 28.49549  -13.69603 7.62384   1.000 33.83783  ? 40  GLU B CG  1 
ATOM   2205 C CD  . GLU B 1 40  ? 29.50977  -13.75582 6.48557   1.000 44.96874  ? 40  GLU B CD  1 
ATOM   2206 O OE1 . GLU B 1 40  ? 29.07739  -13.75756 5.31223   1.000 49.65323  ? 40  GLU B OE1 1 
ATOM   2207 O OE2 . GLU B 1 40  ? 30.74082  -13.79488 6.74622   1.000 47.52851  ? 40  GLU B OE2 1 
ATOM   2208 N N   . ASN B 1 41  ? 24.87254  -10.66960 6.98873   1.000 32.38456  ? 41  ASN B N   1 
ATOM   2209 C CA  . ASN B 1 41  ? 23.49320  -10.37708 6.62254   1.000 31.61337  ? 41  ASN B CA  1 
ATOM   2210 C C   . ASN B 1 41  ? 23.24446  -8.88915  6.44782   1.000 30.49724  ? 41  ASN B C   1 
ATOM   2211 O O   . ASN B 1 41  ? 22.25534  -8.36794  6.96657   1.000 32.51866  ? 41  ASN B O   1 
ATOM   2212 C CB  . ASN B 1 41  ? 22.53551  -10.93538 7.68447   1.000 32.08793  ? 41  ASN B CB  1 
ATOM   2213 C CG  . ASN B 1 41  ? 22.70431  -12.44427 7.89122   1.000 53.66825  ? 41  ASN B CG  1 
ATOM   2214 O OD1 . ASN B 1 41  ? 23.05137  -12.92558 9.01194   1.000 66.54732  ? 41  ASN B OD1 1 
ATOM   2215 N ND2 . ASN B 1 41  ? 22.49753  -13.21306 6.81623   1.000 55.80805  ? 41  ASN B ND2 1 
ATOM   2216 N N   . LEU B 1 42  ? 24.12001  -8.19320  5.74039   1.000 26.66666  ? 42  LEU B N   1 
ATOM   2217 C CA  . LEU B 1 42  ? 23.94253  -6.76407  5.52612   1.000 32.08300  ? 42  LEU B CA  1 
ATOM   2218 C C   . LEU B 1 42  ? 23.36946  -6.51082  4.13235   1.000 41.07037  ? 42  LEU B C   1 
ATOM   2219 O O   . LEU B 1 42  ? 23.52584  -7.32747  3.22656   1.000 46.25585  ? 42  LEU B O   1 
ATOM   2220 C CB  . LEU B 1 42  ? 25.27620  -6.02876  5.69333   1.000 32.05031  ? 42  LEU B CB  1 
ATOM   2221 C CG  . LEU B 1 42  ? 26.03704  -6.13270  7.01730   1.000 25.35554  ? 42  LEU B CG  1 
ATOM   2222 C CD1 . LEU B 1 42  ? 27.34095  -5.42257  6.85928   1.000 23.92994  ? 42  LEU B CD1 1 
ATOM   2223 C CD2 . LEU B 1 42  ? 25.25800  -5.49148  8.13741   1.000 22.60303  ? 42  LEU B CD2 1 
ATOM   2224 N N   . GLU B 1 43  ? 22.72460  -5.35481  3.95762   1.000 40.35514  ? 43  GLU B N   1 
ATOM   2225 C CA  . GLU B 1 43  ? 22.20641  -4.98153  2.64620   1.000 49.61301  ? 43  GLU B CA  1 
ATOM   2226 C C   . GLU B 1 43  ? 23.25192  -4.19612  1.84754   1.000 44.39044  ? 43  GLU B C   1 
ATOM   2227 O O   . GLU B 1 43  ? 24.10554  -3.51947  2.41009   1.000 32.42889  ? 43  GLU B O   1 
ATOM   2228 C CB  . GLU B 1 43  ? 20.92211  -4.15474  2.78118   1.000 47.80943  ? 43  GLU B CB  1 
ATOM   2229 C CG  . GLU B 1 43  ? 19.63506  -4.95597  2.57374   1.000 60.50654  ? 43  GLU B CG  1 
ATOM   2230 C CD  . GLU B 1 43  ? 19.24578  -5.76649  3.80563   1.000 83.32102  ? 43  GLU B CD  1 
ATOM   2231 O OE1 . GLU B 1 43  ? 18.81940  -5.15025  4.81263   1.000 80.78405  ? 43  GLU B OE1 1 
ATOM   2232 O OE2 . GLU B 1 43  ? 19.38285  -7.01561  3.77628   1.000 87.92571  ? 43  GLU B OE2 1 
ATOM   2233 N N   . THR B 1 44  ? 23.13786  -4.25682  0.51369   1.000 47.51758  ? 44  THR B N   1 
ATOM   2234 C CA  . THR B 1 44  ? 24.10823  -3.64900  -0.40084  1.000 45.83307  ? 44  THR B CA  1 
ATOM   2235 C C   . THR B 1 44  ? 23.80425  -2.18071  -0.69488  1.000 57.46120  ? 44  THR B C   1 
ATOM   2236 O O   . THR B 1 44  ? 22.63447  -1.80119  -0.83317  1.000 55.50005  ? 44  THR B O   1 
ATOM   2237 C CB  . THR B 1 44  ? 24.13166  -4.39974  -1.73630  1.000 55.38289  ? 44  THR B CB  1 
ATOM   2238 O OG1 . THR B 1 44  ? 24.04954  -5.81224  -1.50707  1.000 53.99679  ? 44  THR B OG1 1 
ATOM   2239 C CG2 . THR B 1 44  ? 25.40606  -4.07303  -2.50891  1.000 47.40697  ? 44  THR B CG2 1 
ATOM   2240 N N   . ASP B 1 45  ? 24.88369  -1.36798  -0.76293  1.000 53.22659  ? 45  ASP B N   1 
ATOM   2241 C CA  . ASP B 1 45  ? 25.03901  -0.09050  -1.47751  1.000 67.70797  ? 45  ASP B CA  1 
ATOM   2242 C C   . ASP B 1 45  ? 25.31230  1.09787   -0.56232  1.000 77.22824  ? 45  ASP B C   1 
ATOM   2243 O O   . ASP B 1 45  ? 25.99850  0.96593   0.45538   1.000 74.85824  ? 45  ASP B O   1 
ATOM   2244 C CB  . ASP B 1 45  ? 23.83343  0.24046   -2.36155  1.000 73.06134  ? 45  ASP B CB  1 
ATOM   2245 C CG  . ASP B 1 45  ? 23.97569  -0.30747  -3.75877  1.000 81.92174  ? 45  ASP B CG  1 
ATOM   2246 O OD1 . ASP B 1 45  ? 23.97639  -1.54994  -3.91011  1.000 81.88116  ? 45  ASP B OD1 1 
ATOM   2247 O OD2 . ASP B 1 45  ? 24.09288  0.50701   -4.70251  1.000 91.04646  ? 45  ASP B OD2 1 
ATOM   2248 N N   . ARG B 1 46  ? 24.80673  2.27163   -0.94577  1.000 91.03192  ? 46  ARG B N   1 
ATOM   2249 C CA  . ARG B 1 46  ? 25.00697  3.51652   -0.19283  1.000 89.44917  ? 46  ARG B CA  1 
ATOM   2250 C C   . ARG B 1 46  ? 24.46547  3.42656   1.23686   1.000 75.89060  ? 46  ARG B C   1 
ATOM   2251 O O   . ARG B 1 46  ? 24.71137  4.30396   2.06675   1.000 67.83410  ? 46  ARG B O   1 
ATOM   2252 C CB  . ARG B 1 46  ? 24.34816  4.69502   -0.93013  1.000 86.56615  ? 46  ARG B CB  1 
ATOM   2253 C CG  . ARG B 1 46  ? 25.16260  5.23384   -2.09481  1.000 86.25433  ? 46  ARG B CG  1 
ATOM   2254 C CD  . ARG B 1 46  ? 26.45407  5.87605   -1.60519  1.000 85.45756  ? 46  ARG B CD  1 
ATOM   2255 N NE  . ARG B 1 46  ? 27.53671  5.78649   -2.58027  1.000 87.39062  ? 46  ARG B NE  1 
ATOM   2256 C CZ  . ARG B 1 46  ? 27.76940  6.68127   -3.53260  1.000 92.47885  ? 46  ARG B CZ  1 
ATOM   2257 N NH1 . ARG B 1 46  ? 26.98501  7.73684   -3.69753  1.000 95.02180  ? 46  ARG B NH1 1 
ATOM   2258 N NH2 . ARG B 1 46  ? 28.81705  6.51498   -4.33782  1.000 84.97099  ? 46  ARG B NH2 1 
ATOM   2259 N N   . GLY B 1 51  ? 31.07270  -3.65933  -10.15059 1.000 59.25482  ? 51  GLY B N   1 
ATOM   2260 C CA  . GLY B 1 51  ? 32.08700  -2.83022  -10.77721 1.000 54.66480  ? 51  GLY B CA  1 
ATOM   2261 C C   . GLY B 1 51  ? 33.40273  -2.92108  -10.03431 1.000 55.86521  ? 51  GLY B C   1 
ATOM   2262 O O   . GLY B 1 51  ? 34.10642  -1.92098  -9.90770  1.000 74.21601  ? 51  GLY B O   1 
ATOM   2263 N N   . SER B 1 52  ? 33.68906  -4.13013  -9.53472  1.000 57.86182  ? 52  SER B N   1 
ATOM   2264 C CA  . SER B 1 52  ? 34.89776  -4.53240  -8.81260  1.000 48.27633  ? 52  SER B CA  1 
ATOM   2265 C C   . SER B 1 52  ? 34.76136  -4.38454  -7.29690  1.000 47.58734  ? 52  SER B C   1 
ATOM   2266 O O   . SER B 1 52  ? 35.21090  -5.25881  -6.54610  1.000 42.73820  ? 52  SER B O   1 
ATOM   2267 C CB  . SER B 1 52  ? 36.12912  -3.75559  -9.28388  1.000 47.45152  ? 52  SER B CB  1 
ATOM   2268 O OG  . SER B 1 52  ? 37.28766  -4.27263  -8.67728  1.000 50.77763  ? 52  SER B OG  1 
ATOM   2269 N N   . ARG B 1 53  ? 34.18315  -3.27865  -6.83470  1.000 42.99056  ? 53  ARG B N   1 
ATOM   2270 C CA  . ARG B 1 53  ? 34.09308  -2.98119  -5.40936  1.000 43.52874  ? 53  ARG B CA  1 
ATOM   2271 C C   . ARG B 1 53  ? 32.63462  -2.90835  -4.98010  1.000 42.80124  ? 53  ARG B C   1 
ATOM   2272 O O   . ARG B 1 53  ? 31.79510  -2.35491  -5.69089  1.000 43.18525  ? 53  ARG B O   1 
ATOM   2273 C CB  . ARG B 1 53  ? 34.80087  -1.65956  -5.07162  1.000 45.28654  ? 53  ARG B CB  1 
ATOM   2274 C CG  . ARG B 1 53  ? 36.25403  -1.65670  -5.49161  1.000 47.14120  ? 53  ARG B CG  1 
ATOM   2275 C CD  . ARG B 1 53  ? 37.09789  -0.76170  -4.61012  1.000 54.29613  ? 53  ARG B CD  1 
ATOM   2276 N NE  . ARG B 1 53  ? 38.50001  -0.83879  -4.99755  1.000 56.56418  ? 53  ARG B NE  1 
ATOM   2277 C CZ  . ARG B 1 53  ? 39.26936  -1.90322  -4.80701  1.000 61.27601  ? 53  ARG B CZ  1 
ATOM   2278 N NH1 . ARG B 1 53  ? 38.79724  -3.00459  -4.25190  1.000 64.46601  ? 53  ARG B NH1 1 
ATOM   2279 N NH2 . ARG B 1 53  ? 40.54328  -1.86558  -5.18989  1.000 58.82420  ? 53  ARG B NH2 1 
ATOM   2280 N N   . PHE B 1 54  ? 32.32910  -3.47163  -3.81709  1.000 34.67529  ? 54  PHE B N   1 
ATOM   2281 C CA  . PHE B 1 54  ? 30.97861  -3.43907  -3.28331  1.000 33.92467  ? 54  PHE B CA  1 
ATOM   2282 C C   . PHE B 1 54  ? 31.03228  -3.01271  -1.82251  1.000 34.47098  ? 54  PHE B C   1 
ATOM   2283 O O   . PHE B 1 54  ? 32.04762  -3.18637  -1.14355  1.000 27.69096  ? 54  PHE B O   1 
ATOM   2284 C CB  . PHE B 1 54  ? 30.29315  -4.80836  -3.35855  1.000 38.85350  ? 54  PHE B CB  1 
ATOM   2285 C CG  . PHE B 1 54  ? 30.12600  -5.33017  -4.74839  1.000 47.48824  ? 54  PHE B CG  1 
ATOM   2286 C CD1 . PHE B 1 54  ? 31.14022  -6.06669  -5.35644  1.000 47.92744  ? 54  PHE B CD1 1 
ATOM   2287 C CD2 . PHE B 1 54  ? 28.94577  -5.11154  -5.44559  1.000 53.62015  ? 54  PHE B CD2 1 
ATOM   2288 C CE1 . PHE B 1 54  ? 30.97636  -6.57083  -6.64566  1.000 50.71049  ? 54  PHE B CE1 1 
ATOM   2289 C CE2 . PHE B 1 54  ? 28.77688  -5.60822  -6.73005  1.000 54.39795  ? 54  PHE B CE2 1 
ATOM   2290 C CZ  . PHE B 1 54  ? 29.79640  -6.33884  -7.32876  1.000 51.02328  ? 54  PHE B CZ  1 
ATOM   2291 N N   . ARG B 1 55  ? 29.89936  -2.52403  -1.32742  1.000 34.61079  ? 55  ARG B N   1 
ATOM   2292 C CA  . ARG B 1 55  ? 29.76665  -2.13652  0.06825   1.000 34.94578  ? 55  ARG B CA  1 
ATOM   2293 C C   . ARG B 1 55  ? 28.46172  -2.69739  0.60188   1.000 35.12063  ? 55  ARG B C   1 
ATOM   2294 O O   . ARG B 1 55  ? 27.40748  -2.49448  -0.00149  1.000 33.56702  ? 55  ARG B O   1 
ATOM   2295 C CB  . ARG B 1 55  ? 29.79998  -0.61481  0.20607   1.000 42.14295  ? 55  ARG B CB  1 
ATOM   2296 C CG  . ARG B 1 55  ? 30.03631  -0.12623  1.61964   1.000 44.73793  ? 55  ARG B CG  1 
ATOM   2297 C CD  . ARG B 1 55  ? 30.50154  1.32450   1.59301   1.000 53.11980  ? 55  ARG B CD  1 
ATOM   2298 N NE  . ARG B 1 55  ? 29.51552  2.22678   1.01332   1.000 58.44714  ? 55  ARG B NE  1 
ATOM   2299 C CZ  . ARG B 1 55  ? 29.78054  3.16168   0.11199   1.000 56.90432  ? 55  ARG B CZ  1 
ATOM   2300 N NH1 . ARG B 1 55  ? 31.00664  3.34917   -0.35630  1.000 51.89676  ? 55  ARG B NH1 1 
ATOM   2301 N NH2 . ARG B 1 55  ? 28.79377  3.94094   -0.31633  1.000 62.10329  ? 55  ARG B NH2 1 
ATOM   2302 N N   . GLU B 1 56  ? 28.52369  -3.41819  1.70779   1.000 23.38601  ? 56  GLU B N   1 
ATOM   2303 C CA  . GLU B 1 56  ? 27.31177  -3.80796  2.40470   1.000 26.70524  ? 56  GLU B CA  1 
ATOM   2304 C C   . GLU B 1 56  ? 27.29645  -3.09903  3.75998   1.000 27.66289  ? 56  GLU B C   1 
ATOM   2305 O O   . GLU B 1 56  ? 28.35234  -2.81132  4.33574   1.000 24.63237  ? 56  GLU B O   1 
ATOM   2306 C CB  . GLU B 1 56  ? 27.23228  -5.33030  2.51408   1.000 25.70700  ? 56  GLU B CB  1 
ATOM   2307 C CG  . GLU B 1 56  ? 27.08873  -5.95845  1.08744   1.000 32.23910  ? 56  GLU B CG  1 
ATOM   2308 C CD  . GLU B 1 56  ? 27.14769  -7.48735  1.04927   1.000 41.77826  ? 56  GLU B CD  1 
ATOM   2309 O OE1 . GLU B 1 56  ? 27.40389  -8.12725  2.08604   1.000 35.79293  ? 56  GLU B OE1 1 
ATOM   2310 O OE2 . GLU B 1 56  ? 26.91862  -8.06141  -0.04172  1.000 47.99584  ? 56  GLU B OE2 1 
ATOM   2311 N N   . ARG B 1 57  ? 26.10926  -2.74159  4.24136   1.000 25.94769  ? 57  ARG B N   1 
ATOM   2312 C CA  . ARG B 1 57  ? 26.10824  -1.84501  5.39346   1.000 24.55897  ? 57  ARG B CA  1 
ATOM   2313 C C   . ARG B 1 57  ? 24.79165  -1.90150  6.15241   1.000 26.12587  ? 57  ARG B C   1 
ATOM   2314 O O   . ARG B 1 57  ? 23.74414  -2.27573  5.61245   1.000 26.00198  ? 57  ARG B O   1 
ATOM   2315 C CB  . ARG B 1 57  ? 26.39519  -0.39590  4.96474   1.000 25.61409  ? 57  ARG B CB  1 
ATOM   2316 C CG  . ARG B 1 57  ? 25.21293  0.29844   4.24501   1.000 38.77394  ? 57  ARG B CG  1 
ATOM   2317 C CD  . ARG B 1 57  ? 25.27491  1.84681   4.38410   1.000 55.75376  ? 57  ARG B CD  1 
ATOM   2318 N NE  . ARG B 1 57  ? 24.00449  2.53252   4.11774   1.000 70.88456  ? 57  ARG B NE  1 
ATOM   2319 C CZ  . ARG B 1 57  ? 23.21916  3.09523   5.03747   1.000 60.11980  ? 57  ARG B CZ  1 
ATOM   2320 N NH1 . ARG B 1 57  ? 23.53336  3.08612   6.32393   1.000 46.39813  ? 57  ARG B NH1 1 
ATOM   2321 N NH2 . ARG B 1 57  ? 22.08736  3.69196   4.65556   1.000 50.84663  ? 57  ARG B NH2 1 
ATOM   2322 N N   . ALA B 1 58  ? 24.86910  -1.47737  7.42108   1.000 19.31956  ? 58  ALA B N   1 
ATOM   2323 C CA  . ALA B 1 58  ? 23.72545  -1.20930  8.28306   1.000 22.46599  ? 58  ALA B CA  1 
ATOM   2324 C C   . ALA B 1 58  ? 24.10873  -0.05990  9.20858   1.000 22.72676  ? 58  ALA B C   1 
ATOM   2325 O O   . ALA B 1 58  ? 25.29840  0.17051   9.45883   1.000 22.49182  ? 58  ALA B O   1 
ATOM   2326 C CB  . ALA B 1 58  ? 23.32218  -2.44747  9.09639   1.000 24.50727  ? 58  ALA B CB  1 
ATOM   2327 N N   . TYR B 1 59  ? 23.11375  0.68588   9.68828   1.000 19.45885  ? 59  TYR B N   1 
ATOM   2328 C CA  . TYR B 1 59  ? 23.45465  1.85410   10.48381  1.000 20.96971  ? 59  TYR B CA  1 
ATOM   2329 C C   . TYR B 1 59  ? 22.29061  2.23574   11.40508  1.000 27.03295  ? 59  TYR B C   1 
ATOM   2330 O O   . TYR B 1 59  ? 21.12097  1.93664   11.11288  1.000 20.71468  ? 59  TYR B O   1 
ATOM   2331 C CB  . TYR B 1 59  ? 23.85055  3.00654   9.53450   1.000 30.48508  ? 59  TYR B CB  1 
ATOM   2332 C CG  . TYR B 1 59  ? 23.42686  4.37721   9.96910   1.000 38.01084  ? 59  TYR B CG  1 
ATOM   2333 C CD1 . TYR B 1 59  ? 24.22445  5.14387   10.82560  1.000 43.89601  ? 59  TYR B CD1 1 
ATOM   2334 C CD2 . TYR B 1 59  ? 22.22695  4.92401   9.52740   1.000 44.95601  ? 59  TYR B CD2 1 
ATOM   2335 C CE1 . TYR B 1 59  ? 23.83954  6.40285   11.22988  1.000 27.71977  ? 59  TYR B CE1 1 
ATOM   2336 C CE2 . TYR B 1 59  ? 21.83452  6.17993   9.94164   1.000 39.88405  ? 59  TYR B CE2 1 
ATOM   2337 C CZ  . TYR B 1 59  ? 22.63738  6.89855   10.78499  1.000 41.16601  ? 59  TYR B CZ  1 
ATOM   2338 O OH  . TYR B 1 59  ? 22.23924  8.14916   11.15132  1.000 68.80601  ? 59  TYR B OH  1 
ATOM   2339 N N   . ASP B 1 60  ? 22.63231  2.86675   12.54298  1.000 22.87307  ? 60  ASP B N   1 
ATOM   2340 C CA  . ASP B 1 60  ? 21.65291  3.51128   13.41796  1.000 18.78745  ? 60  ASP B CA  1 
ATOM   2341 C C   . ASP B 1 60  ? 22.36567  4.56414   14.26341  1.000 21.62479  ? 60  ASP B C   1 
ATOM   2342 O O   . ASP B 1 60  ? 23.59529  4.62202   14.32245  1.000 22.97351  ? 60  ASP B O   1 
ATOM   2343 C CB  . ASP B 1 60  ? 20.92737  2.50677   14.32342  1.000 20.73575  ? 60  ASP B CB  1 
ATOM   2344 C CG  . ASP B 1 60  ? 19.67835  1.90833   13.66948  1.000 28.40011  ? 60  ASP B CG  1 
ATOM   2345 O OD1 . ASP B 1 60  ? 18.79338  2.68821   13.20414  1.000 22.16292  ? 60  ASP B OD1 1 
ATOM   2346 O OD2 . ASP B 1 60  ? 19.61724  0.64696   13.61581  1.000 27.16056  ? 60  ASP B OD2 1 
ATOM   2347 N N   . ARG B 1 61  ? 21.56682  5.39884   14.91942  1.000 17.82091  ? 61  ARG B N   1 
ATOM   2348 C CA  . ARG B 1 61  ? 22.04819  6.43053   15.83135  1.000 20.72782  ? 61  ARG B CA  1 
ATOM   2349 C C   . ARG B 1 61  ? 21.53395  6.14008   17.23241  1.000 21.19965  ? 61  ARG B C   1 
ATOM   2350 O O   . ARG B 1 61  ? 20.42571  5.60628   17.39536  1.000 19.47379  ? 61  ARG B O   1 
ATOM   2351 C CB  . ARG B 1 61  ? 21.56983  7.83326   15.42707  1.000 21.77558  ? 61  ARG B CB  1 
ATOM   2352 C CG  . ARG B 1 61  ? 22.15940  8.35919   14.10995  1.000 27.59228  ? 61  ARG B CG  1 
ATOM   2353 C CD  . ARG B 1 61  ? 21.47365  9.68061   13.72326  1.000 26.05460  ? 61  ARG B CD  1 
ATOM   2354 N NE  . ARG B 1 61  ? 20.04261  9.46438   13.58366  1.000 25.50735  ? 61  ARG B NE  1 
ATOM   2355 C CZ  . ARG B 1 61  ? 19.09908  10.36520  13.80947  1.000 31.38128  ? 61  ARG B CZ  1 
ATOM   2356 N NH1 . ARG B 1 61  ? 19.39624  11.63233  14.04718  1.000 34.67788  ? 61  ARG B NH1 1 
ATOM   2357 N NH2 . ARG B 1 61  ? 17.82575  9.97620   13.81280  1.000 27.27644  ? 61  ARG B NH2 1 
ATOM   2358 N N   . PHE B 1 62  ? 22.32204  6.54492   18.24461  1.000 16.24870  ? 62  PHE B N   1 
ATOM   2359 C CA  . PHE B 1 62  ? 21.88984  6.42667   19.63149  1.000 17.76525  ? 62  PHE B CA  1 
ATOM   2360 C C   . PHE B 1 62  ? 22.00160  7.76789   20.31640  1.000 19.50844  ? 62  PHE B C   1 
ATOM   2361 O O   . PHE B 1 62  ? 22.92869  8.52923   20.05562  1.000 18.86071  ? 62  PHE B O   1 
ATOM   2362 C CB  . PHE B 1 62  ? 22.73717  5.38792   20.42591  1.000 15.11773  ? 62  PHE B CB  1 
ATOM   2363 C CG  . PHE B 1 62  ? 22.65917  3.97765   19.84970  1.000 18.32877  ? 62  PHE B CG  1 
ATOM   2364 C CD1 . PHE B 1 62  ? 21.64402  3.08549   20.24378  1.000 19.20048  ? 62  PHE B CD1 1 
ATOM   2365 C CD2 . PHE B 1 62  ? 23.60453  3.54160   18.91960  1.000 19.46635  ? 62  PHE B CD2 1 
ATOM   2366 C CE1 . PHE B 1 62  ? 21.56983  1.76997   19.70063  1.000 21.87300  ? 62  PHE B CE1 1 
ATOM   2367 C CE2 . PHE B 1 62  ? 23.52396  2.22375   18.34195  1.000 21.53286  ? 62  PHE B CE2 1 
ATOM   2368 C CZ  . PHE B 1 62  ? 22.51217  1.34320   18.75255  1.000 20.78546  ? 62  PHE B CZ  1 
ATOM   2369 N N   . PHE B 1 63  ? 21.04397  8.02832   21.18963  1.000 17.05003  ? 63  PHE B N   1 
ATOM   2370 C CA  . PHE B 1 63  ? 21.13351  9.04412   22.22833  1.000 17.66482  ? 63  PHE B CA  1 
ATOM   2371 C C   . PHE B 1 63  ? 21.96329  8.48163   23.38671  1.000 16.13580  ? 63  PHE B C   1 
ATOM   2372 O O   . PHE B 1 63  ? 21.64925  7.40896   23.90737  1.000 17.42338  ? 63  PHE B O   1 
ATOM   2373 C CB  . PHE B 1 63  ? 19.68732  9.38940   22.64795  1.000 16.75080  ? 63  PHE B CB  1 
ATOM   2374 C CG  . PHE B 1 63  ? 19.56387  10.30006  23.85166  1.000 21.13878  ? 63  PHE B CG  1 
ATOM   2375 C CD1 . PHE B 1 63  ? 19.68174  9.79019   25.13892  1.000 20.11479  ? 63  PHE B CD1 1 
ATOM   2376 C CD2 . PHE B 1 63  ? 19.28244  11.65655  23.69266  1.000 21.97564  ? 63  PHE B CD2 1 
ATOM   2377 C CE1 . PHE B 1 63  ? 19.52578  10.62746  26.23949  1.000 22.83780  ? 63  PHE B CE1 1 
ATOM   2378 C CE2 . PHE B 1 63  ? 19.14960  12.50751  24.78149  1.000 25.71185  ? 63  PHE B CE2 1 
ATOM   2379 C CZ  . PHE B 1 63  ? 19.26449  11.99315  26.07240  1.000 23.47483  ? 63  PHE B CZ  1 
ATOM   2380 N N   . PHE B 1 64  ? 22.99001  9.20957   23.82327  1.000 16.23037  ? 64  PHE B N   1 
ATOM   2381 C CA  . PHE B 1 64  ? 23.93719  8.70038   24.81850  1.000 17.60658  ? 64  PHE B CA  1 
ATOM   2382 C C   . PHE B 1 64  ? 24.31336  9.78125   25.82695  1.000 18.63106  ? 64  PHE B C   1 
ATOM   2383 O O   . PHE B 1 64  ? 24.72989  10.88661  25.43774  1.000 18.42225  ? 64  PHE B O   1 
ATOM   2384 C CB  . PHE B 1 64  ? 25.19339  8.16160   24.08121  1.000 20.12449  ? 64  PHE B CB  1 
ATOM   2385 C CG  . PHE B 1 64  ? 26.35030  7.78338   24.97202  1.000 15.50167  ? 64  PHE B CG  1 
ATOM   2386 C CD1 . PHE B 1 64  ? 26.18057  6.91967   26.06759  1.000 16.77712  ? 64  PHE B CD1 1 
ATOM   2387 C CD2 . PHE B 1 64  ? 27.62062  8.27134   24.71206  1.000 20.44675  ? 64  PHE B CD2 1 
ATOM   2388 C CE1 . PHE B 1 64  ? 27.28262  6.57069   26.88195  1.000 14.60086  ? 64  PHE B CE1 1 
ATOM   2389 C CE2 . PHE B 1 64  ? 28.71109  7.92670   25.50978  1.000 16.65954  ? 64  PHE B CE2 1 
ATOM   2390 C CZ  . PHE B 1 64  ? 28.54024  7.05373   26.58130  1.000 18.79037  ? 64  PHE B CZ  1 
ATOM   2391 N N   . VAL B 1 65  ? 24.14439  9.47511   27.11614  1.000 16.78891  ? 65  VAL B N   1 
ATOM   2392 C CA  . VAL B 1 65  ? 24.59083  10.36511  28.19018  1.000 15.85695  ? 65  VAL B CA  1 
ATOM   2393 C C   . VAL B 1 65  ? 25.68653  9.64638   28.97613  1.000 19.00247  ? 65  VAL B C   1 
ATOM   2394 O O   . VAL B 1 65  ? 25.39961  8.63272   29.63757  1.000 18.19874  ? 65  VAL B O   1 
ATOM   2395 C CB  . VAL B 1 65  ? 23.43895  10.79008  29.11606  1.000 15.18619  ? 65  VAL B CB  1 
ATOM   2396 C CG1 . VAL B 1 65  ? 23.99166  11.63392  30.25861  1.000 16.47747  ? 65  VAL B CG1 1 
ATOM   2397 C CG2 . VAL B 1 65  ? 22.38647  11.62029  28.34743  1.000 19.17364  ? 65  VAL B CG2 1 
ATOM   2398 N N   . PRO B 1 66  ? 26.94478  10.09654  28.90760  1.000 16.81425  ? 66  PRO B N   1 
ATOM   2399 C CA  . PRO B 1 66  ? 28.03388  9.30895   29.51845  1.000 18.89041  ? 66  PRO B CA  1 
ATOM   2400 C C   . PRO B 1 66  ? 27.90599  9.10491   31.01829  1.000 20.13658  ? 66  PRO B C   1 
ATOM   2401 O O   . PRO B 1 66  ? 28.19807  8.00580   31.50878  1.000 19.56751  ? 66  PRO B O   1 
ATOM   2402 C CB  . PRO B 1 66  ? 29.29439  10.12144  29.17799  1.000 18.36809  ? 66  PRO B CB  1 
ATOM   2403 C CG  . PRO B 1 66  ? 28.95217  10.79740  27.87800  1.000 21.40096  ? 66  PRO B CG  1 
ATOM   2404 C CD  . PRO B 1 66  ? 27.45497  11.12212  27.97573  1.000 17.18290  ? 66  PRO B CD  1 
ATOM   2405 N N   A ARG B 1 67  ? 27.48995  10.13773  31.75903  0.429 19.22478  ? 67  ARG B N   1 
ATOM   2406 N N   B ARG B 1 67  ? 27.49955  10.12133  31.77725  0.571 19.10371  ? 67  ARG B N   1 
ATOM   2407 C CA  A ARG B 1 67  ? 27.47874  10.05622  33.21912  0.429 22.41661  ? 67  ARG B CA  1 
ATOM   2408 C CA  B ARG B 1 67  ? 27.54388  9.96968   33.22945  0.571 22.41605  ? 67  ARG B CA  1 
ATOM   2409 C C   A ARG B 1 67  ? 26.61757  8.89455   33.69565  0.429 20.82481  ? 67  ARG B C   1 
ATOM   2410 C C   B ARG B 1 67  ? 26.62084  8.85194   33.70024  0.571 20.81202  ? 67  ARG B C   1 
ATOM   2411 O O   A ARG B 1 67  ? 27.03143  8.11595   34.56081  0.429 20.37038  ? 67  ARG B O   1 
ATOM   2412 O O   B ARG B 1 67  ? 26.99679  8.06278   34.57232  0.571 20.41783  ? 67  ARG B O   1 
ATOM   2413 C CB  A ARG B 1 67  ? 26.97510  11.36721  33.82489  0.429 24.26748  ? 67  ARG B CB  1 
ATOM   2414 C CB  B ARG B 1 67  ? 27.18975  11.27432  33.92877  0.571 24.02387  ? 67  ARG B CB  1 
ATOM   2415 C CG  A ARG B 1 67  ? 27.78498  11.86728  35.03604  0.429 29.72709  ? 67  ARG B CG  1 
ATOM   2416 C CG  B ARG B 1 67  ? 27.02986  11.11907  35.44886  0.571 24.82844  ? 67  ARG B CG  1 
ATOM   2417 C CD  A ARG B 1 67  ? 28.90933  12.76942  34.52005  0.429 32.06759  ? 67  ARG B CD  1 
ATOM   2418 C CD  B ARG B 1 67  ? 28.27086  10.56802  36.15877  0.571 26.75313  ? 67  ARG B CD  1 
ATOM   2419 N NE  A ARG B 1 67  ? 29.42794  13.69364  35.51287  0.429 32.97105  ? 67  ARG B NE  1 
ATOM   2420 N NE  B ARG B 1 67  ? 28.07368  10.44763  37.60578  0.571 23.91525  ? 67  ARG B NE  1 
ATOM   2421 C CZ  A ARG B 1 67  ? 30.65449  13.63251  36.00302  0.429 33.14567  ? 67  ARG B CZ  1 
ATOM   2422 C CZ  B ARG B 1 67  ? 27.56756  9.39269   38.23856  0.571 22.59071  ? 67  ARG B CZ  1 
ATOM   2423 N NH1 A ARG B 1 67  ? 31.49894  12.69388  35.62828  0.429 33.77621  ? 67  ARG B NH1 1 
ATOM   2424 N NH1 B ARG B 1 67  ? 27.25031  8.27006   37.59089  0.571 16.98833  ? 67  ARG B NH1 1 
ATOM   2425 N NH2 A ARG B 1 67  ? 31.04259  14.53617  36.89429  0.429 52.04091  ? 67  ARG B NH2 1 
ATOM   2426 N NH2 B ARG B 1 67  ? 27.37205  9.46407   39.55655  0.571 14.80602  ? 67  ARG B NH2 1 
ATOM   2427 N N   . THR B 1 68  ? 25.42062  8.75559   33.12798  1.000 17.92781  ? 68  THR B N   1 
ATOM   2428 C CA  . THR B 1 68  ? 24.47206  7.72946   33.54888  1.000 20.10098  ? 68  THR B CA  1 
ATOM   2429 C C   . THR B 1 68  ? 24.55109  6.46024   32.72694  1.000 20.82800  ? 68  THR B C   1 
ATOM   2430 O O   . THR B 1 68  ? 23.89590  5.46675   33.08112  1.000 17.66926  ? 68  THR B O   1 
ATOM   2431 C CB  . THR B 1 68  ? 23.05059  8.25206   33.46599  1.000 20.12584  ? 68  THR B CB  1 
ATOM   2432 O OG1 . THR B 1 68  ? 22.77036  8.64386   32.11647  1.000 18.24863  ? 68  THR B OG1 1 
ATOM   2433 C CG2 . THR B 1 68  ? 22.90831  9.48395   34.37715  1.000 19.34757  ? 68  THR B CG2 1 
ATOM   2434 N N   . GLY B 1 69  ? 25.31829  6.46867   31.63801  1.000 18.37342  ? 69  GLY B N   1 
ATOM   2435 C CA  . GLY B 1 69  ? 25.32723  5.34910   30.72661  1.000 17.02174  ? 69  GLY B CA  1 
ATOM   2436 C C   . GLY B 1 69  ? 24.07012  5.19594   29.89195  1.000 14.70710  ? 69  GLY B C   1 
ATOM   2437 O O   . GLY B 1 69  ? 23.90257  4.15505   29.24096  1.000 19.58518  ? 69  GLY B O   1 
ATOM   2438 N N   . GLU B 1 70  ? 23.17577  6.18343   29.91328  1.000 13.08663  ? 70  GLU B N   1 
ATOM   2439 C CA  . GLU B 1 70  ? 21.89738  6.06970   29.22409  1.000 12.11550  ? 70  GLU B CA  1 
ATOM   2440 C C   . GLU B 1 70  ? 22.14740  5.95728   27.71936  1.000 16.66885  ? 70  GLU B C   1 
ATOM   2441 O O   . GLU B 1 70  ? 22.87157  6.77953   27.14850  1.000 15.21484  ? 70  GLU B O   1 
ATOM   2442 C CB  . GLU B 1 70  ? 21.00472  7.29943   29.51669  1.000 15.52331  ? 70  GLU B CB  1 
ATOM   2443 C CG  . GLU B 1 70  ? 19.62680  7.20367   28.84047  1.000 17.24217  ? 70  GLU B CG  1 
ATOM   2444 C CD  . GLU B 1 70  ? 18.71607  8.43737   29.10645  1.000 20.00469  ? 70  GLU B CD  1 
ATOM   2445 O OE1 . GLU B 1 70  ? 19.19759  9.46602   29.62694  1.000 20.37042  ? 70  GLU B OE1 1 
ATOM   2446 O OE2 . GLU B 1 70  ? 17.51065  8.36115   28.77625  1.000 20.16710  ? 70  GLU B OE2 1 
ATOM   2447 N N   . VAL B 1 71  ? 21.57842  4.91692   27.09096  1.000 13.77426  ? 71  VAL B N   1 
ATOM   2448 C CA  . VAL B 1 71  ? 21.65295  4.70613   25.64359  1.000 14.21032  ? 71  VAL B CA  1 
ATOM   2449 C C   . VAL B 1 71  ? 20.24001  4.46602   25.14034  1.000 20.65513  ? 71  VAL B C   1 
ATOM   2450 O O   . VAL B 1 71  ? 19.56550  3.54082   25.61975  1.000 15.49718  ? 71  VAL B O   1 
ATOM   2451 C CB  . VAL B 1 71  ? 22.54853  3.50164   25.27783  1.000 14.12269  ? 71  VAL B CB  1 
ATOM   2452 C CG1 . VAL B 1 71  ? 22.47496  3.20842   23.73869  1.000 13.63741  ? 71  VAL B CG1 1 
ATOM   2453 C CG2 . VAL B 1 71  ? 23.97395  3.75037   25.70990  1.000 15.25917  ? 71  VAL B CG2 1 
ATOM   2454 N N   . ARG B 1 72  ? 19.78658  5.27655   24.16570  1.000 14.62020  ? 72  ARG B N   1 
ATOM   2455 C CA  . ARG B 1 72  ? 18.47846  5.04425   23.54401  1.000 14.30751  ? 72  ARG B CA  1 
ATOM   2456 C C   . ARG B 1 72  ? 18.63806  4.96417   22.03698  1.000 17.65792  ? 72  ARG B C   1 
ATOM   2457 O O   . ARG B 1 72  ? 19.30006  5.81566   21.44830  1.000 17.01747  ? 72  ARG B O   1 
ATOM   2458 C CB  . ARG B 1 72  ? 17.46996  6.16688   23.86220  1.000 16.70363  ? 72  ARG B CB  1 
ATOM   2459 C CG  . ARG B 1 72  ? 17.24069  6.42138   25.36295  1.000 18.74612  ? 72  ARG B CG  1 
ATOM   2460 C CD  . ARG B 1 72  ? 16.52849  7.80261   25.53807  1.000 17.21498  ? 72  ARG B CD  1 
ATOM   2461 N NE  . ARG B 1 72  ? 15.31708  7.90708   24.72576  1.000 17.07895  ? 72  ARG B NE  1 
ATOM   2462 C CZ  . ARG B 1 72  ? 14.10680  7.56239   25.14810  1.000 28.00786  ? 72  ARG B CZ  1 
ATOM   2463 N NH1 . ARG B 1 72  ? 13.91821  7.02362   26.35603  1.000 23.78708  ? 72  ARG B NH1 1 
ATOM   2464 N NH2 . ARG B 1 72  ? 13.05531  7.77676   24.35582  1.000 24.85144  ? 72  ARG B NH2 1 
ATOM   2465 N N   . LEU B 1 73  ? 18.04575  3.95785   21.41328  1.000 17.92067  ? 73  LEU B N   1 
ATOM   2466 C CA  . LEU B 1 73  ? 18.04409  3.90617   19.95295  1.000 19.50649  ? 73  LEU B CA  1 
ATOM   2467 C C   . LEU B 1 73  ? 17.16821  5.02743   19.39020  1.000 24.57285  ? 73  LEU B C   1 
ATOM   2468 O O   . LEU B 1 73  ? 16.06035  5.25768   19.87445  1.000 24.29749  ? 73  LEU B O   1 
ATOM   2469 C CB  . LEU B 1 73  ? 17.52443  2.56387   19.48991  1.000 19.15173  ? 73  LEU B CB  1 
ATOM   2470 C CG  . LEU B 1 73  ? 17.35029  2.39790   17.96409  1.000 22.89256  ? 73  LEU B CG  1 
ATOM   2471 C CD1 . LEU B 1 73  ? 18.71615  2.37364   17.26060  1.000 20.42451  ? 73  LEU B CD1 1 
ATOM   2472 C CD2 . LEU B 1 73  ? 16.52957  1.14229   17.68372  1.000 24.93044  ? 73  LEU B CD2 1 
ATOM   2473 N N   . ARG B 1 74  ? 17.67798  5.75780   18.40474  1.000 22.95108  ? 74  ARG B N   1 
ATOM   2474 C CA  . ARG B 1 74  ? 16.91697  6.86229   17.82698  1.000 21.02988  ? 74  ARG B CA  1 
ATOM   2475 C C   . ARG B 1 74  ? 16.16413  6.40260   16.58264  1.000 22.23794  ? 74  ARG B C   1 
ATOM   2476 O O   . ARG B 1 74  ? 16.50105  5.36598   15.99464  1.000 20.94705  ? 74  ARG B O   1 
ATOM   2477 C CB  . ARG B 1 74  ? 17.86360  8.01399   17.45768  1.000 22.42436  ? 74  ARG B CB  1 
ATOM   2478 C CG  . ARG B 1 74  ? 18.62915  8.59691   18.61322  1.000 20.66953  ? 74  ARG B CG  1 
ATOM   2479 C CD  . ARG B 1 74  ? 19.50359  9.77777   18.16915  1.000 22.48851  ? 74  ARG B CD  1 
ATOM   2480 N NE  . ARG B 1 74  ? 18.66484  10.88661  17.70452  1.000 25.03386  ? 74  ARG B NE  1 
ATOM   2481 C CZ  . ARG B 1 74  ? 19.11687  12.04085  17.23357  1.000 27.61296  ? 74  ARG B CZ  1 
ATOM   2482 N NH1 . ARG B 1 74  ? 20.40997  12.29169  17.14538  1.000 25.47545  ? 74  ARG B NH1 1 
ATOM   2483 N NH2 . ARG B 1 74  ? 18.24182  12.98316  16.87111  1.000 29.81616  ? 74  ARG B NH2 1 
ATOM   2484 N N   . PRO B 1 75  ? 15.16808  7.17585   16.12148  1.000 23.52539  ? 75  PRO B N   1 
ATOM   2485 C CA  . PRO B 1 75  ? 14.47357  6.80628   14.87753  1.000 27.60890  ? 75  PRO B CA  1 
ATOM   2486 C C   . PRO B 1 75  ? 15.46689  6.69195   13.73254  1.000 25.04953  ? 75  PRO B C   1 
ATOM   2487 O O   . PRO B 1 75  ? 16.45111  7.43055   13.66379  1.000 23.81522  ? 75  PRO B O   1 
ATOM   2488 C CB  . PRO B 1 75  ? 13.47927  7.95856   14.65318  1.000 32.00291  ? 75  PRO B CB  1 
ATOM   2489 C CG  . PRO B 1 75  ? 13.26945  8.55832   16.01985  1.000 32.30765  ? 75  PRO B CG  1 
ATOM   2490 C CD  . PRO B 1 75  ? 14.60658  8.40158   16.73705  1.000 28.49716  ? 75  PRO B CD  1 
ATOM   2491 N N   . HIS B 1 76  ? 15.22818  5.72510   12.85131  1.000 25.34711  ? 76  HIS B N   1 
ATOM   2492 C CA  . HIS B 1 76  ? 16.18171  5.43727   11.78182  1.000 25.33197  ? 76  HIS B CA  1 
ATOM   2493 C C   . HIS B 1 76  ? 16.07730  6.49821   10.68104  1.000 27.75245  ? 76  HIS B C   1 
ATOM   2494 O O   . HIS B 1 76  ? 15.06882  6.55690   9.97661   1.000 27.31482  ? 76  HIS B O   1 
ATOM   2495 C CB  . HIS B 1 76  ? 15.92736  4.05222   11.20850  1.000 27.79333  ? 76  HIS B CB  1 
ATOM   2496 C CG  . HIS B 1 76  ? 16.90915  3.67463   10.14522  1.000 28.95554  ? 76  HIS B CG  1 
ATOM   2497 N ND1 . HIS B 1 76  ? 18.19070  3.25798   10.43829  1.000 25.21437  ? 76  HIS B ND1 1 
ATOM   2498 C CD2 . HIS B 1 76  ? 16.81096  3.66826   8.79259   1.000 28.22008  ? 76  HIS B CD2 1 
ATOM   2499 C CE1 . HIS B 1 76  ? 18.83783  2.99894   9.30990   1.000 30.45755  ? 76  HIS B CE1 1 
ATOM   2500 N NE2 . HIS B 1 76  ? 18.02315  3.24411   8.29821   1.000 30.05964  ? 76  HIS B NE2 1 
ATOM   2501 N N   . ARG B 1 77  ? 17.13033  7.30258   10.51296  1.000 27.82384  ? 77  ARG B N   1 
ATOM   2502 C CA  . ARG B 1 77  ? 17.16669  8.43888   9.58423   1.000 28.02073  ? 77  ARG B CA  1 
ATOM   2503 C C   . ARG B 1 77  ? 18.41727  8.43081   8.69742   1.000 26.89272  ? 77  ARG B C   1 
ATOM   2504 O O   . ARG B 1 77  ? 19.40911  9.09626   9.01216   1.000 30.56684  ? 77  ARG B O   1 
ATOM   2505 C CB  . ARG B 1 77  ? 17.11469  9.74454   10.36634  1.000 29.86811  ? 77  ARG B CB  1 
ATOM   2506 C CG  . ARG B 1 77  ? 15.82889  9.96044   11.16982  1.000 33.11763  ? 77  ARG B CG  1 
ATOM   2507 C CD  . ARG B 1 77  ? 14.61453  10.14994  10.24422  1.000 34.48551  ? 77  ARG B CD  1 
ATOM   2508 N NE  . ARG B 1 77  ? 13.39036  10.33559  11.00765  1.000 33.00259  ? 77  ARG B NE  1 
ATOM   2509 C CZ  . ARG B 1 77  ? 12.53255  9.37055   11.30391  1.000 32.65990  ? 77  ARG B CZ  1 
ATOM   2510 N NH1 . ARG B 1 77  ? 12.69986  8.13128   10.85888  1.000 34.86700  ? 77  ARG B NH1 1 
ATOM   2511 N NH2 . ARG B 1 77  ? 11.47536  9.65535   12.06158  1.000 35.42030  ? 77  ARG B NH2 1 
ATOM   2512 N N   . PRO B 1 78  ? 18.38525  7.74368   7.55059   1.000 28.35652  ? 78  PRO B N   1 
ATOM   2513 C CA  . PRO B 1 78  ? 19.60064  7.63965   6.70384   1.000 35.27022  ? 78  PRO B CA  1 
ATOM   2514 C C   . PRO B 1 78  ? 20.30727  8.95863   6.40495   1.000 39.98555  ? 78  PRO B C   1 
ATOM   2515 O O   . PRO B 1 78  ? 21.54029  8.97105   6.30272   1.000 40.16456  ? 78  PRO B O   1 
ATOM   2516 C CB  . PRO B 1 78  ? 19.07651  6.98976   5.41539   1.000 40.84187  ? 78  PRO B CB  1 
ATOM   2517 C CG  . PRO B 1 78  ? 17.85735  6.19724   5.85476   1.000 41.24112  ? 78  PRO B CG  1 
ATOM   2518 C CD  . PRO B 1 78  ? 17.23252  7.01740   6.98490   1.000 32.92614  ? 78  PRO B CD  1 
ATOM   2519 N N   . TYR B 1 79  ? 19.58951  10.08106  6.28457   1.000 34.80311  ? 79  TYR B N   1 
ATOM   2520 C CA  . TYR B 1 79  ? 20.28977  11.30467  5.91422   1.000 41.17376  ? 79  TYR B CA  1 
ATOM   2521 C C   . TYR B 1 79  ? 21.06273  11.91413  7.06697   1.000 44.58917  ? 79  TYR B C   1 
ATOM   2522 O O   . TYR B 1 79  ? 21.92097  12.77248  6.82788   1.000 45.52264  ? 79  TYR B O   1 
ATOM   2523 C CB  . TYR B 1 79  ? 19.32045  12.33534  5.33001   1.000 39.99560  ? 79  TYR B CB  1 
ATOM   2524 C CG  . TYR B 1 79  ? 19.10471  12.09313  3.85431   1.000 37.94112  ? 79  TYR B CG  1 
ATOM   2525 C CD1 . TYR B 1 79  ? 19.94774  12.66484  2.90288   1.000 31.81045  ? 79  TYR B CD1 1 
ATOM   2526 C CD2 . TYR B 1 79  ? 18.08025  11.26562  3.42437   1.000 29.64976  ? 79  TYR B CD2 1 
ATOM   2527 C CE1 . TYR B 1 79  ? 19.77566  12.41642  1.55627   1.000 31.38716  ? 79  TYR B CE1 1 
ATOM   2528 C CE2 . TYR B 1 79  ? 17.88808  11.00022  2.07470   1.000 31.84432  ? 79  TYR B CE2 1 
ATOM   2529 C CZ  . TYR B 1 79  ? 18.73084  11.58496  1.14398   1.000 35.35949  ? 79  TYR B CZ  1 
ATOM   2530 O OH  . TYR B 1 79  ? 18.51879  11.32339  -0.19732  1.000 32.85080  ? 79  TYR B OH  1 
ATOM   2531 N N   . PHE B 1 80  ? 20.80235  11.48129  8.29847   1.000 37.88635  ? 80  PHE B N   1 
ATOM   2532 C CA  . PHE B 1 80  ? 21.55942  11.96809  9.44215   1.000 39.84163  ? 80  PHE B CA  1 
ATOM   2533 C C   . PHE B 1 80  ? 22.80798  11.14326  9.72270   1.000 47.19880  ? 80  PHE B C   1 
ATOM   2534 O O   . PHE B 1 80  ? 23.44827  11.34290  10.76184  1.000 48.34073  ? 80  PHE B O   1 
ATOM   2535 C CB  . PHE B 1 80  ? 20.66853  12.00655  10.67577  1.000 38.32379  ? 80  PHE B CB  1 
ATOM   2536 C CG  . PHE B 1 80  ? 19.68630  13.13697  10.66087  1.000 42.83380  ? 80  PHE B CG  1 
ATOM   2537 C CD1 . PHE B 1 80  ? 18.46710  12.99700  10.03108  1.000 46.65303  ? 80  PHE B CD1 1 
ATOM   2538 C CD2 . PHE B 1 80  ? 19.99648  14.34683  11.26129  1.000 44.56811  ? 80  PHE B CD2 1 
ATOM   2539 C CE1 . PHE B 1 80  ? 17.56293  14.04026  10.01418  1.000 50.89841  ? 80  PHE B CE1 1 
ATOM   2540 C CE2 . PHE B 1 80  ? 19.10164  15.39030  11.24644  1.000 51.74653  ? 80  PHE B CE2 1 
ATOM   2541 C CZ  . PHE B 1 80  ? 17.88202  15.23662  10.62595  1.000 49.39754  ? 80  PHE B CZ  1 
ATOM   2542 N N   . GLN B 1 81  ? 23.15848  10.21568  8.83591   1.000 46.45092  ? 81  GLN B N   1 
ATOM   2543 C CA  . GLN B 1 81  ? 24.46292  9.57504   8.90041   1.000 49.84034  ? 81  GLN B CA  1 
ATOM   2544 C C   . GLN B 1 81  ? 25.51836  10.48363  8.27177   1.000 52.94419  ? 81  GLN B C   1 
ATOM   2545 O O   . GLN B 1 81  ? 25.22712  11.29154  7.37835   1.000 60.58601  ? 81  GLN B O   1 
ATOM   2546 C CB  . GLN B 1 81  ? 24.43890  8.22173   8.18664   1.000 45.96269  ? 81  GLN B CB  1 
ATOM   2547 C CG  . GLN B 1 81  ? 25.30471  8.20835   6.92491   1.000 55.08254  ? 81  GLN B CG  1 
ATOM   2548 C CD  . GLN B 1 81  ? 24.95550  7.09055   5.96400   1.000 65.35925  ? 81  GLN B CD  1 
ATOM   2549 O OE1 . GLN B 1 81  ? 24.07869  6.26854   6.24146   1.000 61.78601  ? 81  GLN B OE1 1 
ATOM   2550 N NE2 . GLN B 1 81  ? 25.64716  7.05221   4.82154   1.000 67.12550  ? 81  GLN B NE2 1 
ATOM   2551 N N   . SER B 1 82  ? 26.75347  10.35835  8.76966   1.000 45.99485  ? 82  SER B N   1 
ATOM   2552 C CA  . SER B 1 82  ? 27.89351  11.09605  8.23896   1.000 47.25763  ? 82  SER B CA  1 
ATOM   2553 C C   . SER B 1 82  ? 29.14850  10.23369  8.16682   1.000 59.11601  ? 82  SER B C   1 
ATOM   2554 O O   . SER B 1 82  ? 30.19081  10.71038  7.68514   1.000 54.18570  ? 82  SER B O   1 
ATOM   2555 C CB  . SER B 1 82  ? 28.17772  12.35089  9.09387   1.000 43.53841  ? 82  SER B CB  1 
ATOM   2556 O OG  . SER B 1 82  ? 28.77479  12.02257  10.35559  1.000 40.98809  ? 82  SER B OG  1 
ATOM   2557 N N   . MET B 1 83  ? 29.08433  8.99512   8.65612   1.000 47.84029  ? 83  MET B N   1 
ATOM   2558 C CA  . MET B 1 83  ? 30.20867  8.07327   8.68210   1.000 45.14823  ? 83  MET B CA  1 
ATOM   2559 C C   . MET B 1 83  ? 30.24458  7.31095   7.37300   1.000 43.43651  ? 83  MET B C   1 
ATOM   2560 O O   . MET B 1 83  ? 29.20015  6.90398   6.85894   1.000 46.10433  ? 83  MET B O   1 
ATOM   2561 C CB  . MET B 1 83  ? 30.05086  7.08329   9.83193   1.000 45.81433  ? 83  MET B CB  1 
ATOM   2562 C CG  . MET B 1 83  ? 31.13465  7.08726   10.83696  1.000 78.71601  ? 83  MET B CG  1 
ATOM   2563 S SD  . MET B 1 83  ? 30.94730  8.28333   12.16621  1.000 39.55411  ? 83  MET B SD  1 
ATOM   2564 C CE  . MET B 1 83  ? 32.66014  8.05616   12.79727  1.000 24.92182  ? 83  MET B CE  1 
ATOM   2565 N N   . ASN B 1 84  ? 31.43561  7.11155   6.83792   1.000 35.61024  ? 84  ASN B N   1 
ATOM   2566 C CA  . ASN B 1 84  ? 31.56193  6.41823   5.56345   1.000 42.65045  ? 84  ASN B CA  1 
ATOM   2567 C C   . ASN B 1 84  ? 32.49062  5.23149   5.75661   1.000 38.41758  ? 84  ASN B C   1 
ATOM   2568 O O   . ASN B 1 84  ? 33.18015  5.12789   6.77946   1.000 47.01485  ? 84  ASN B O   1 
ATOM   2569 C CB  . ASN B 1 84  ? 32.07699  7.36139   4.46545   1.000 41.22881  ? 84  ASN B CB  1 
ATOM   2570 C CG  . ASN B 1 84  ? 33.47184  7.87085   4.74857   1.000 50.31601  ? 84  ASN B CG  1 
ATOM   2571 O OD1 . ASN B 1 84  ? 33.93241  7.85746   5.90524   1.000 35.47121  ? 84  ASN B OD1 1 
ATOM   2572 N ND2 . ASN B 1 84  ? 34.16756  8.31589   3.69282   1.000 46.29514  ? 84  ASN B ND2 1 
ATOM   2573 N N   . ALA B 1 85  ? 32.49605  4.31881   4.77640   1.000 35.39531  ? 85  ALA B N   1 
ATOM   2574 C CA  . ALA B 1 85  ? 33.31041  3.11292   4.87179   1.000 35.99338  ? 85  ALA B CA  1 
ATOM   2575 C C   . ALA B 1 85  ? 34.76295  3.33584   4.46727   1.000 48.88230  ? 85  ALA B C   1 
ATOM   2576 O O   . ALA B 1 85  ? 35.55987  2.39159   4.54891   1.000 46.49844  ? 85  ALA B O   1 
ATOM   2577 C CB  . ALA B 1 85  ? 32.72182  1.99260   4.01083   1.000 41.21542  ? 85  ALA B CB  1 
ATOM   2578 N N   . ASN B 1 86  ? 35.12304  4.54856   4.02385   1.000 46.29185  ? 86  ASN B N   1 
ATOM   2579 C CA  . ASN B 1 86  ? 36.49107  4.86851   3.60084   1.000 44.18977  ? 86  ASN B CA  1 
ATOM   2580 C C   . ASN B 1 86  ? 36.93411  4.00085   2.41678   1.000 51.61196  ? 86  ASN B C   1 
ATOM   2581 O O   . ASN B 1 86  ? 38.12457  3.71736   2.25463   1.000 49.18684  ? 86  ASN B O   1 
ATOM   2582 C CB  . ASN B 1 86  ? 37.50104  4.71747   4.74953   1.000 44.29610  ? 86  ASN B CB  1 
ATOM   2583 C CG  . ASN B 1 86  ? 37.04197  5.36392   6.07422   1.000 41.25576  ? 86  ASN B CG  1 
ATOM   2584 O OD1 . ASN B 1 86  ? 36.81045  4.66309   7.07086   1.000 48.36448  ? 86  ASN B OD1 1 
ATOM   2585 N ND2 . ASN B 1 86  ? 36.96396  6.68679   6.10172   1.000 33.75242  ? 86  ASN B ND2 1 
ATOM   2586 N N   . ASP B 1 87  ? 35.99456  3.55905   1.58294   1.000 49.01400  ? 87  ASP B N   1 
ATOM   2587 C CA  . ASP B 1 87  ? 36.31297  2.64442   0.48355   1.000 53.39067  ? 87  ASP B CA  1 
ATOM   2588 C C   . ASP B 1 87  ? 36.26695  3.34755   -0.88142  1.000 58.75398  ? 87  ASP B C   1 
ATOM   2589 O O   . ASP B 1 87  ? 36.16513  2.69165   -1.92538  1.000 68.38791  ? 87  ASP B O   1 
ATOM   2590 C CB  . ASP B 1 87  ? 35.35502  1.43120   0.49732   1.000 54.37264  ? 87  ASP B CB  1 
ATOM   2591 C CG  . ASP B 1 87  ? 33.89483  1.80358   0.16141   1.000 55.16817  ? 87  ASP B CG  1 
ATOM   2592 O OD1 . ASP B 1 87  ? 33.46505  2.94682   0.42725   1.000 46.82437  ? 87  ASP B OD1 1 
ATOM   2593 O OD2 . ASP B 1 87  ? 33.16936  0.93905   -0.37890  1.000 54.54758  ? 87  ASP B OD2 1 
ATOM   2594 N N   . ASP B 1 93  ? 23.13863  9.67324   4.33679   1.000 62.02283  ? 93  ASP B N   1 
ATOM   2595 C CA  . ASP B 1 93  ? 22.64393  10.21812  3.07263   1.000 51.45742  ? 93  ASP B CA  1 
ATOM   2596 C C   . ASP B 1 93  ? 22.23257  9.13843   2.04556   1.000 55.40455  ? 93  ASP B C   1 
ATOM   2597 O O   . ASP B 1 93  ? 22.68219  9.19517   0.90705   1.000 73.05084  ? 93  ASP B O   1 
ATOM   2598 C CB  . ASP B 1 93  ? 23.71006  11.14487  2.47457   1.000 45.46250  ? 93  ASP B CB  1 
ATOM   2599 N N   . ARG B 1 94  ? 21.36944  8.17681   2.42139   1.000 63.48601  ? 94  ARG B N   1 
ATOM   2600 C CA  . ARG B 1 94  ? 21.04692  7.05280   1.53402   1.000 57.88565  ? 94  ARG B CA  1 
ATOM   2601 C C   . ARG B 1 94  ? 19.73931  6.32587   1.88384   1.000 54.10328  ? 94  ARG B C   1 
ATOM   2602 O O   . ARG B 1 94  ? 18.72104  6.96648   2.16186   1.000 59.57204  ? 94  ARG B O   1 
ATOM   2603 C CB  . ARG B 1 94  ? 22.21333  6.05750   1.52211   1.000 56.00610  ? 94  ARG B CB  1 
ATOM   2604 N N   . ASP B 1 95  ? 19.74705  4.99229   1.86168   1.000 54.60382  ? 95  ASP B N   1 
ATOM   2605 C CA  . ASP B 1 95  ? 18.54698  4.16563   1.96643   1.000 53.39696  ? 95  ASP B CA  1 
ATOM   2606 C C   . ASP B 1 95  ? 18.38113  3.56404   3.36667   1.000 56.24730  ? 95  ASP B C   1 
ATOM   2607 O O   . ASP B 1 95  ? 19.30030  3.57136   4.18954   1.000 52.88028  ? 95  ASP B O   1 
ATOM   2608 C CB  . ASP B 1 95  ? 18.58924  3.04187   0.92468   1.000 53.00495  ? 95  ASP B CB  1 
ATOM   2609 N N   . VAL B 1 96  ? 17.18550  3.01252   3.62137   1.000 46.32829  ? 96  VAL B N   1 
ATOM   2610 C CA  . VAL B 1 96  ? 16.88111  2.41429   4.92128   1.000 48.29974  ? 96  VAL B CA  1 
ATOM   2611 C C   . VAL B 1 96  ? 17.68363  1.12762   5.10645   1.000 54.30601  ? 96  VAL B C   1 
ATOM   2612 O O   . VAL B 1 96  ? 17.57033  0.20535   4.29091   1.000 45.48696  ? 96  VAL B O   1 
ATOM   2613 C CB  . VAL B 1 96  ? 15.38324  2.12802   5.04308   1.000 48.28702  ? 96  VAL B CB  1 
ATOM   2614 N N   . ALA B 1 97  ? 18.49371  1.05773   6.17394   1.000 38.43741  ? 97  ALA B N   1 
ATOM   2615 C CA  . ALA B 1 97  ? 19.32009  -0.12411  6.45132   1.000 35.70776  ? 97  ALA B CA  1 
ATOM   2616 C C   . ALA B 1 97  ? 19.64373  -0.20501  7.94325   1.000 28.94206  ? 97  ALA B C   1 
ATOM   2617 O O   . ALA B 1 97  ? 20.80461  -0.10441  8.34899   1.000 27.07891  ? 97  ALA B O   1 
ATOM   2618 C CB  . ALA B 1 97  ? 20.59766  -0.08717  5.61159   1.000 29.25767  ? 97  ALA B CB  1 
ATOM   2619 N N   . PRO B 1 98  ? 18.63058  -0.38598  8.78510   1.000 25.63142  ? 98  PRO B N   1 
ATOM   2620 C CA  . PRO B 1 98  ? 18.86188  -0.40411  10.23768  1.000 27.98333  ? 98  PRO B CA  1 
ATOM   2621 C C   . PRO B 1 98  ? 19.66970  -1.61261  10.68667  1.000 28.88898  ? 98  PRO B C   1 
ATOM   2622 O O   . PRO B 1 98  ? 19.71032  -2.65406  10.02193  1.000 25.72133  ? 98  PRO B O   1 
ATOM   2623 C CB  . PRO B 1 98  ? 17.44337  -0.44490  10.82146  1.000 28.10717  ? 98  PRO B CB  1 
ATOM   2624 C CG  . PRO B 1 98  ? 16.60129  -1.09282  9.70471   1.000 29.98793  ? 98  PRO B CG  1 
ATOM   2625 C CD  . PRO B 1 98  ? 17.19397  -0.49883  8.45101   1.000 31.25591  ? 98  PRO B CD  1 
ATOM   2626 N N   . LEU B 1 99  ? 20.34429  -1.44962  11.83569  1.000 23.83225  ? 99  LEU B N   1 
ATOM   2627 C CA  . LEU B 1 99  ? 20.97568  -2.57908  12.48573  1.000 19.10581  ? 99  LEU B CA  1 
ATOM   2628 C C   . LEU B 1 99  ? 19.94195  -3.67248  12.71476  1.000 23.82285  ? 99  LEU B C   1 
ATOM   2629 O O   . LEU B 1 99  ? 18.77613  -3.39173  13.00024  1.000 25.24456  ? 99  LEU B O   1 
ATOM   2630 C CB  . LEU B 1 99  ? 21.58889  -2.15805  13.82714  1.000 23.20002  ? 99  LEU B CB  1 
ATOM   2631 C CG  . LEU B 1 99  ? 22.62180  -1.01598  13.76303  1.000 23.75294  ? 99  LEU B CG  1 
ATOM   2632 C CD1 . LEU B 1 99  ? 22.96941  -0.54040  15.19289  1.000 21.58794  ? 99  LEU B CD1 1 
ATOM   2633 C CD2 . LEU B 1 99  ? 23.86190  -1.46561  12.94976  1.000 18.92031  ? 99  LEU B CD2 1 
ATOM   2634 N N   . SER B 1 100 ? 20.37573  -4.91900  12.58547  1.000 22.54693  ? 100 SER B N   1 
ATOM   2635 C CA  . SER B 1 100 ? 19.48108  -6.05967  12.73128  1.000 26.75643  ? 100 SER B CA  1 
ATOM   2636 C C   . SER B 1 100 ? 19.02293  -6.24579  14.17695  1.000 28.23887  ? 100 SER B C   1 
ATOM   2637 O O   . SER B 1 100 ? 19.64965  -5.76929  15.12873  1.000 23.91955  ? 100 SER B O   1 
ATOM   2638 C CB  . SER B 1 100 ? 20.17031  -7.35219  12.27004  1.000 29.33221  ? 100 SER B CB  1 
ATOM   2639 O OG  . SER B 1 100 ? 21.18671  -7.74976  13.16935  1.000 29.72871  ? 100 SER B OG  1 
ATOM   2640 N N   A ARG B 1 101 ? 17.90840  -6.96775  14.32861  0.517 27.27171  ? 101 ARG B N   1 
ATOM   2641 N N   B ARG B 1 101 ? 17.91568  -6.97678  14.33743  0.483 27.28572  ? 101 ARG B N   1 
ATOM   2642 C CA  A ARG B 1 101 ? 17.39325  -7.29777  15.65692  0.517 30.89281  ? 101 ARG B CA  1 
ATOM   2643 C CA  B ARG B 1 101 ? 17.41292  -7.26626  15.67991  0.483 30.82537  ? 101 ARG B CA  1 
ATOM   2644 C C   A ARG B 1 101 ? 18.45242  -7.98405  16.50941  0.517 30.04171  ? 101 ARG B C   1 
ATOM   2645 C C   B ARG B 1 101 ? 18.45880  -7.98599  16.51996  0.483 30.04980  ? 101 ARG B C   1 
ATOM   2646 O O   A ARG B 1 101 ? 18.64666  -7.63924  17.67895  0.517 28.12277  ? 101 ARG B O   1 
ATOM   2647 O O   B ARG B 1 101 ? 18.65081  -7.66106  17.69589  0.483 28.15092  ? 101 ARG B O   1 
ATOM   2648 C CB  A ARG B 1 101 ? 16.16570  -8.20384  15.52484  0.517 36.05580  ? 101 ARG B CB  1 
ATOM   2649 C CB  B ARG B 1 101 ? 16.14145  -8.11283  15.59907  0.483 36.07819  ? 101 ARG B CB  1 
ATOM   2650 C CG  A ARG B 1 101 ? 14.83530  -7.55300  15.82326  0.517 46.48277  ? 101 ARG B CG  1 
ATOM   2651 C CG  B ARG B 1 101 ? 14.97498  -7.57260  16.39125  0.483 46.67495  ? 101 ARG B CG  1 
ATOM   2652 C CD  A ARG B 1 101 ? 14.35103  -7.97262  17.20633  0.517 52.31919  ? 101 ARG B CD  1 
ATOM   2653 C CD  B ARG B 1 101 ? 14.41750  -8.60536  17.37318  0.483 52.46797  ? 101 ARG B CD  1 
ATOM   2654 N NE  A ARG B 1 101 ? 12.95186  -8.38337  17.22169  0.517 59.66443  ? 101 ARG B NE  1 
ATOM   2655 N NE  B ARG B 1 101 ? 15.10521  -8.54157  18.65872  0.483 57.25601  ? 101 ARG B NE  1 
ATOM   2656 C CZ  A ARG B 1 101 ? 11.93869  -7.58081  17.51894  0.517 66.02808  ? 101 ARG B CZ  1 
ATOM   2657 C CZ  B ARG B 1 101 ? 14.71375  -9.16774  19.76005  0.483 54.52367  ? 101 ARG B CZ  1 
ATOM   2658 N NH1 A ARG B 1 101 ? 12.12971  -6.30211  17.80124  0.517 58.83051  ? 101 ARG B NH1 1 
ATOM   2659 N NH1 B ARG B 1 101 ? 13.62100  -9.91771  19.78063  0.483 57.98899  ? 101 ARG B NH1 1 
ATOM   2660 N NH2 A ARG B 1 101 ? 10.70234  -8.07488  17.53504  0.517 72.17431  ? 101 ARG B NH2 1 
ATOM   2661 N NH2 B ARG B 1 101 ? 15.43565  -9.03598  20.86890  0.483 48.60883  ? 101 ARG B NH2 1 
ATOM   2662 N N   . THR B 1 102 ? 19.15818  -8.95788  15.92993  1.000 28.22525  ? 102 THR B N   1 
ATOM   2663 C CA  . THR B 1 102 ? 20.15679  -9.70146  16.69597  1.000 32.25610  ? 102 THR B CA  1 
ATOM   2664 C C   . THR B 1 102 ? 21.42878  -8.89105  16.94559  1.000 28.60882  ? 102 THR B C   1 
ATOM   2665 O O   . THR B 1 102 ? 22.12137  -9.13622  17.92896  1.000 31.42734  ? 102 THR B O   1 
ATOM   2666 C CB  . THR B 1 102 ? 20.50815  -11.00196 15.98545  1.000 37.38691  ? 102 THR B CB  1 
ATOM   2667 O OG1 . THR B 1 102 ? 20.83638  -10.70355 14.62300  1.000 38.14361  ? 102 THR B OG1 1 
ATOM   2668 C CG2 . THR B 1 102 ? 19.34310  -11.97237 16.04716  1.000 41.17734  ? 102 THR B CG2 1 
ATOM   2669 N N   . THR B 1 103 ? 21.76954  -7.92658  16.08804  1.000 27.79629  ? 103 THR B N   1 
ATOM   2670 C CA  . THR B 1 103 ? 22.81965  -6.99106  16.48750  1.000 25.49478  ? 103 THR B CA  1 
ATOM   2671 C C   . THR B 1 103 ? 22.38341  -6.20667  17.71323  1.000 23.40370  ? 103 THR B C   1 
ATOM   2672 O O   . THR B 1 103 ? 23.12774  -6.08593  18.68925  1.000 23.70666  ? 103 THR B O   1 
ATOM   2673 C CB  . THR B 1 103 ? 23.14741  -6.02027  15.35304  1.000 20.55797  ? 103 THR B CB  1 
ATOM   2674 O OG1 . THR B 1 103 ? 23.63614  -6.75286  14.23330  1.000 24.85004  ? 103 THR B OG1 1 
ATOM   2675 C CG2 . THR B 1 103 ? 24.18582  -5.02106  15.80411  1.000 18.22808  ? 103 THR B CG2 1 
ATOM   2676 N N   . LEU B 1 104 ? 21.16235  -5.65161  17.67461  1.000 23.76807  ? 104 LEU B N   1 
ATOM   2677 C CA  . LEU B 1 104 ? 20.71986  -4.81251  18.76947  1.000 26.13134  ? 104 LEU B CA  1 
ATOM   2678 C C   . LEU B 1 104 ? 20.52725  -5.60265  20.05536  1.000 27.21132  ? 104 LEU B C   1 
ATOM   2679 O O   . LEU B 1 104 ? 20.64167  -5.03427  21.14741  1.000 25.98193  ? 104 LEU B O   1 
ATOM   2680 C CB  . LEU B 1 104 ? 19.43520  -4.09441  18.39485  1.000 30.21623  ? 104 LEU B CB  1 
ATOM   2681 C CG  . LEU B 1 104 ? 19.52024  -3.06385  17.26161  1.000 24.52573  ? 104 LEU B CG  1 
ATOM   2682 C CD1 . LEU B 1 104 ? 18.09564  -2.65044  16.91879  1.000 35.28835  ? 104 LEU B CD1 1 
ATOM   2683 C CD2 . LEU B 1 104 ? 20.30941  -1.89870  17.77311  1.000 24.70254  ? 104 LEU B CD2 1 
ATOM   2684 N N   . ALA B 1 105 ? 20.23474  -6.89562  19.95970  1.000 26.34513  ? 105 ALA B N   1 
ATOM   2685 C CA  . ALA B 1 105 ? 20.02081  -7.68873  21.17628  1.000 26.66578  ? 105 ALA B CA  1 
ATOM   2686 C C   . ALA B 1 105 ? 21.31612  -8.22435  21.78575  1.000 31.73791  ? 105 ALA B C   1 
ATOM   2687 O O   . ALA B 1 105 ? 21.27288  -8.81365  22.86655  1.000 29.74501  ? 105 ALA B O   1 
ATOM   2688 C CB  . ALA B 1 105 ? 19.07310  -8.85918  20.87597  1.000 30.26959  ? 105 ALA B CB  1 
ATOM   2689 N N   . ASN B 1 106 ? 22.46051  -8.04628  21.13026  1.000 28.01616  ? 106 ASN B N   1 
ATOM   2690 C CA  . ASN B 1 106 ? 23.74930  -8.51330  21.67129  1.000 23.33174  ? 106 ASN B CA  1 
ATOM   2691 C C   . ASN B 1 106 ? 24.25749  -7.50441  22.70547  1.000 28.04309  ? 106 ASN B C   1 
ATOM   2692 O O   . ASN B 1 106 ? 24.46034  -6.33215  22.35946  1.000 25.51295  ? 106 ASN B O   1 
ATOM   2693 C CB  . ASN B 1 106 ? 24.72811  -8.64883  20.49723  1.000 25.83454  ? 106 ASN B CB  1 
ATOM   2694 C CG  . ASN B 1 106 ? 26.02965  -9.34476  20.85979  1.000 24.66300  ? 106 ASN B CG  1 
ATOM   2695 O OD1 . ASN B 1 106 ? 26.53938  -9.20295  21.96088  1.000 26.33621  ? 106 ASN B OD1 1 
ATOM   2696 N ND2 . ASN B 1 106 ? 26.58242  -10.08764 19.90241  1.000 24.34046  ? 106 ASN B ND2 1 
ATOM   2697 N N   . PRO B 1 107 ? 24.46138  -7.88894  23.97025  1.000 28.61909  ? 107 PRO B N   1 
ATOM   2698 C CA  . PRO B 1 107 ? 24.88011  -6.88026  24.96356  1.000 26.98657  ? 107 PRO B CA  1 
ATOM   2699 C C   . PRO B 1 107 ? 26.22333  -6.27941  24.65182  1.000 23.99971  ? 107 PRO B C   1 
ATOM   2700 O O   . PRO B 1 107 ? 26.53753  -5.20055  25.17561  1.000 21.92860  ? 107 PRO B O   1 
ATOM   2701 C CB  . PRO B 1 107 ? 24.92251  -7.65419  26.29021  1.000 28.25038  ? 107 PRO B CB  1 
ATOM   2702 C CG  . PRO B 1 107 ? 25.15718  -9.06686  25.87645  1.000 28.48193  ? 107 PRO B CG  1 
ATOM   2703 C CD  . PRO B 1 107 ? 24.40930  -9.24522  24.55296  1.000 33.77848  ? 107 PRO B CD  1 
ATOM   2704 N N   . LEU B 1 108 ? 27.01895  -6.92394  23.78424  1.000 20.40464  ? 108 LEU B N   1 
ATOM   2705 C CA  . LEU B 1 108 ? 28.33332  -6.38735  23.51055  1.000 20.47908  ? 108 LEU B CA  1 
ATOM   2706 C C   . LEU B 1 108 ? 28.23951  -5.01019  22.85064  1.000 22.30376  ? 108 LEU B C   1 
ATOM   2707 O O   . LEU B 1 108 ? 29.10829  -4.16890  23.05249  1.000 21.08676  ? 108 LEU B O   1 
ATOM   2708 C CB  . LEU B 1 108 ? 29.11340  -7.36385  22.63454  1.000 21.32552  ? 108 LEU B CB  1 
ATOM   2709 C CG  . LEU B 1 108 ? 30.51854  -6.89863  22.28716  1.000 24.91594  ? 108 LEU B CG  1 
ATOM   2710 C CD1 . LEU B 1 108 ? 31.32307  -6.48717  23.54671  1.000 22.09949  ? 108 LEU B CD1 1 
ATOM   2711 C CD2 . LEU B 1 108 ? 31.25039  -7.99557  21.52146  1.000 27.22728  ? 108 LEU B CD2 1 
ATOM   2712 N N   . LEU B 1 109 ? 27.17742  -4.74862  22.09910  1.000 20.62051  ? 109 LEU B N   1 
ATOM   2713 C CA  . LEU B 1 109 ? 27.12546  -3.52163  21.29845  1.000 22.03219  ? 109 LEU B CA  1 
ATOM   2714 C C   . LEU B 1 109 ? 27.17496  -2.28066  22.16715  1.000 19.50831  ? 109 LEU B C   1 
ATOM   2715 O O   . LEU B 1 109 ? 28.03657  -1.41335  21.98875  1.000 20.28987  ? 109 LEU B O   1 
ATOM   2716 C CB  . LEU B 1 109 ? 25.85968  -3.48029  20.46134  1.000 22.93681  ? 109 LEU B CB  1 
ATOM   2717 C CG  . LEU B 1 109 ? 25.78018  -2.27761  19.49075  1.000 19.48752  ? 109 LEU B CG  1 
ATOM   2718 C CD1 . LEU B 1 109 ? 26.91674  -2.30679  18.50380  1.000 19.91369  ? 109 LEU B CD1 1 
ATOM   2719 C CD2 . LEU B 1 109 ? 24.45383  -2.30196  18.75512  1.000 24.35599  ? 109 LEU B CD2 1 
ATOM   2720 N N   . THR B 1 110 ? 26.20205  -2.14083  23.08009  1.000 21.10768  ? 110 THR B N   1 
ATOM   2721 C CA  . THR B 1 110 ? 26.21693  -0.96602  23.94009  1.000 22.45553  ? 110 THR B CA  1 
ATOM   2722 C C   . THR B 1 110 ? 27.37128  -0.99646  24.92425  1.000 16.81338  ? 110 THR B C   1 
ATOM   2723 O O   . THR B 1 110 ? 27.81708  0.07736   25.35166  1.000 18.34277  ? 110 THR B O   1 
ATOM   2724 C CB  . THR B 1 110 ? 24.89171  -0.79583  24.69286  1.000 20.78261  ? 110 THR B CB  1 
ATOM   2725 O OG1 . THR B 1 110 ? 24.66842  -1.95768  25.48808  1.000 23.52981  ? 110 THR B OG1 1 
ATOM   2726 C CG2 . THR B 1 110 ? 23.74017  -0.58232  23.72108  1.000 22.72642  ? 110 THR B CG2 1 
ATOM   2727 N N   . ARG B 1 111 ? 27.84965  -2.18488  25.32552  1.000 17.48767  ? 111 ARG B N   1 
ATOM   2728 C CA  . ARG B 1 111 ? 29.03377  -2.23033  26.19547  1.000 21.98577  ? 111 ARG B CA  1 
ATOM   2729 C C   . ARG B 1 111 ? 30.25380  -1.62325  25.50363  1.000 20.78143  ? 111 ARG B C   1 
ATOM   2730 O O   . ARG B 1 111 ? 30.99912  -0.84408  26.10924  1.000 18.17599  ? 111 ARG B O   1 
ATOM   2731 C CB  . ARG B 1 111 ? 29.31790  -3.67195  26.63342  1.000 19.34534  ? 111 ARG B CB  1 
ATOM   2732 C CG  . ARG B 1 111 ? 28.32336  -4.09200  27.72816  1.000 29.55144  ? 111 ARG B CG  1 
ATOM   2733 C CD  . ARG B 1 111 ? 28.45788  -5.55500  28.19480  1.000 27.08655  ? 111 ARG B CD  1 
ATOM   2734 N NE  . ARG B 1 111 ? 27.52042  -5.85652  29.28544  1.000 25.57772  ? 111 ARG B NE  1 
ATOM   2735 C CZ  . ARG B 1 111 ? 27.08865  -7.08270  29.55506  1.000 34.02490  ? 111 ARG B CZ  1 
ATOM   2736 N NH1 . ARG B 1 111 ? 27.40647  -8.11256  28.77555  1.000 31.39377  ? 111 ARG B NH1 1 
ATOM   2737 N NH2 . ARG B 1 111 ? 26.31971  -7.28419  30.62421  1.000 24.91523  ? 111 ARG B NH2 1 
ATOM   2738 N N   . LEU B 1 112 ? 30.46565  -1.97023  24.22953  1.000 18.67740  ? 112 LEU B N   1 
ATOM   2739 C CA  . LEU B 1 112 ? 31.49390  -1.30778  23.43394  1.000 21.04493  ? 112 LEU B CA  1 
ATOM   2740 C C   . LEU B 1 112 ? 31.23699  0.18449   23.33690  1.000 18.46129  ? 112 LEU B C   1 
ATOM   2741 O O   . LEU B 1 112 ? 32.15062  1.00059   23.49485  1.000 20.49079  ? 112 LEU B O   1 
ATOM   2742 C CB  . LEU B 1 112 ? 31.54281  -1.92347  22.02852  1.000 20.65985  ? 112 LEU B CB  1 
ATOM   2743 C CG  . LEU B 1 112 ? 32.23679  -3.27929  21.92180  1.000 21.24358  ? 112 LEU B CG  1 
ATOM   2744 C CD1 . LEU B 1 112 ? 32.25088  -3.78420  20.46124  1.000 20.67631  ? 112 LEU B CD1 1 
ATOM   2745 C CD2 . LEU B 1 112 ? 33.65824  -3.17882  22.48763  1.000 26.51867  ? 112 LEU B CD2 1 
ATOM   2746 N N   . LEU B 1 113 ? 29.99202  0.56543   23.05271  1.000 18.34035  ? 113 LEU B N   1 
ATOM   2747 C CA  . LEU B 1 113 ? 29.67918  1.98978   22.94912  1.000 16.34550  ? 113 LEU B CA  1 
ATOM   2748 C C   . LEU B 1 113 ? 30.12122  2.72522   24.20462  1.000 19.60328  ? 113 LEU B C   1 
ATOM   2749 O O   . LEU B 1 113 ? 30.74605  3.78602   24.11896  1.000 18.31780  ? 113 LEU B O   1 
ATOM   2750 C CB  . LEU B 1 113 ? 28.17255  2.19922   22.69061  1.000 15.47792  ? 113 LEU B CB  1 
ATOM   2751 C CG  . LEU B 1 113 ? 27.66655  3.61028   22.41185  1.000 23.01420  ? 113 LEU B CG  1 
ATOM   2752 C CD1 . LEU B 1 113 ? 26.35531  3.61409   21.59474  1.000 18.23823  ? 113 LEU B CD1 1 
ATOM   2753 C CD2 . LEU B 1 113 ? 27.45550  4.38894   23.74368  1.000 18.38008  ? 113 LEU B CD2 1 
ATOM   2754 N N   . ARG B 1 114 ? 29.81084  2.17159   25.39297  1.000 17.51105  ? 114 ARG B N   1 
ATOM   2755 C CA  . ARG B 1 114 ? 30.16428  2.90190   26.61133  1.000 18.08159  ? 114 ARG B CA  1 
ATOM   2756 C C   . ARG B 1 114 ? 31.65250  2.79629   26.90671  1.000 19.98662  ? 114 ARG B C   1 
ATOM   2757 O O   . ARG B 1 114 ? 32.27243  3.78863   27.30633  1.000 19.84543  ? 114 ARG B O   1 
ATOM   2758 C CB  . ARG B 1 114 ? 29.38529  2.37995   27.81857  1.000 19.69978  ? 114 ARG B CB  1 
ATOM   2759 C CG  . ARG B 1 114 ? 27.86413  2.51224   27.72635  1.000 18.26676  ? 114 ARG B CG  1 
ATOM   2760 C CD  . ARG B 1 114 ? 27.21676  2.13173   29.09196  1.000 17.82073  ? 114 ARG B CD  1 
ATOM   2761 N NE  . ARG B 1 114 ? 25.77184  2.11513   28.94763  1.000 20.71738  ? 114 ARG B NE  1 
ATOM   2762 C CZ  . ARG B 1 114 ? 25.09107  1.06091   28.53263  1.000 18.48171  ? 114 ARG B CZ  1 
ATOM   2763 N NH1 . ARG B 1 114 ? 25.68587  -0.10396  28.33541  1.000 18.26499  ? 114 ARG B NH1 1 
ATOM   2764 N NH2 . ARG B 1 114 ? 23.78641  1.18495   28.29510  1.000 18.44514  ? 114 ARG B NH2 1 
ATOM   2765 N N   . ALA B 1 115 ? 32.22746  1.59030   26.75398  1.000 17.13088  ? 115 ALA B N   1 
ATOM   2766 C CA  . ALA B 1 115 ? 33.64932  1.42164   27.06208  1.000 21.16533  ? 115 ALA B CA  1 
ATOM   2767 C C   . ALA B 1 115 ? 34.52021  2.24999   26.11771  1.000 28.82755  ? 115 ALA B C   1 
ATOM   2768 O O   . ALA B 1 115 ? 35.44445  2.95199   26.56369  1.000 23.97415  ? 115 ALA B O   1 
ATOM   2769 C CB  . ALA B 1 115 ? 34.03644  -0.05978  27.00807  1.000 23.17720  ? 115 ALA B CB  1 
ATOM   2770 N N   . ASP B 1 116 ? 34.20555  2.24115   24.81152  1.000 19.73127  ? 116 ASP B N   1 
ATOM   2771 C CA  . ASP B 1 116 ? 35.01927  3.02881   23.88736  1.000 22.26497  ? 116 ASP B CA  1 
ATOM   2772 C C   . ASP B 1 116 ? 35.07662  4.49915   24.30055  1.000 25.65085  ? 116 ASP B C   1 
ATOM   2773 O O   . ASP B 1 116 ? 36.13545  5.13449   24.21864  1.000 24.77741  ? 116 ASP B O   1 
ATOM   2774 C CB  . ASP B 1 116 ? 34.49515  2.90539   22.46782  1.000 17.65646  ? 116 ASP B CB  1 
ATOM   2775 C CG  . ASP B 1 116 ? 34.69819  1.51220   21.87054  1.000 22.46174  ? 116 ASP B CG  1 
ATOM   2776 O OD1 . ASP B 1 116 ? 35.51740  0.71926   22.35592  1.000 24.99786  ? 116 ASP B OD1 1 
ATOM   2777 O OD2 . ASP B 1 116 ? 33.99272  1.19742   20.89285  1.000 25.69616  ? 116 ASP B OD2 1 
ATOM   2778 N N   . PHE B 1 117 ? 33.94825  5.05531   24.75921  1.000 22.96903  ? 117 PHE B N   1 
ATOM   2779 C CA  . PHE B 1 117 ? 33.92622  6.45820   25.13007  1.000 22.63064  ? 117 PHE B CA  1 
ATOM   2780 C C   . PHE B 1 117 ? 34.92929  6.79199   26.24626  1.000 25.28687  ? 117 PHE B C   1 
ATOM   2781 O O   . PHE B 1 117 ? 35.44731  7.91099   26.28959  1.000 24.37688  ? 117 PHE B O   1 
ATOM   2782 C CB  . PHE B 1 117 ? 32.49870  6.87160   25.52142  1.000 19.47271  ? 117 PHE B CB  1 
ATOM   2783 C CG  . PHE B 1 117 ? 32.34388  8.36200   25.78099  1.000 24.11509  ? 117 PHE B CG  1 
ATOM   2784 C CD1 . PHE B 1 117 ? 32.07000  9.23712   24.73079  1.000 21.48553  ? 117 PHE B CD1 1 
ATOM   2785 C CD2 . PHE B 1 117 ? 32.49568  8.88089   27.06574  1.000 20.49776  ? 117 PHE B CD2 1 
ATOM   2786 C CE1 . PHE B 1 117 ? 31.93918  10.62356  24.95431  1.000 21.82572  ? 117 PHE B CE1 1 
ATOM   2787 C CE2 . PHE B 1 117 ? 32.36777  10.24710  27.30447  1.000 27.02001  ? 117 PHE B CE2 1 
ATOM   2788 C CZ  . PHE B 1 117 ? 32.07770  11.12427  26.23733  1.000 23.02264  ? 117 PHE B CZ  1 
ATOM   2789 N N   . GLU B 1 118 ? 35.26460  5.84491   27.11853  1.000 25.54196  ? 118 GLU B N   1 
ATOM   2790 C CA  . GLU B 1 118 ? 36.17198  6.20673   28.20518  1.000 28.23915  ? 118 GLU B CA  1 
ATOM   2791 C C   . GLU B 1 118 ? 37.58491  6.49287   27.71363  1.000 36.70589  ? 118 GLU B C   1 
ATOM   2792 O O   . GLU B 1 118 ? 38.40391  7.00166   28.48787  1.000 36.00910  ? 118 GLU B O   1 
ATOM   2793 C CB  . GLU B 1 118 ? 36.19261  5.09832   29.24939  1.000 27.93601  ? 118 GLU B CB  1 
ATOM   2794 C CG  . GLU B 1 118 ? 34.81057  4.89746   29.89874  1.000 35.16796  ? 118 GLU B CG  1 
ATOM   2795 C CD  . GLU B 1 118 ? 34.32373  6.16206   30.62419  1.000 41.55191  ? 118 GLU B CD  1 
ATOM   2796 O OE1 . GLU B 1 118 ? 35.18408  6.85135   31.21273  1.000 45.04014  ? 118 GLU B OE1 1 
ATOM   2797 O OE2 . GLU B 1 118 ? 33.10206  6.48477   30.59089  1.000 39.78376  ? 118 GLU B OE2 1 
ATOM   2798 N N   . ASN B 1 119 ? 37.87573  6.20759   26.44870  1.000 31.73926  ? 119 ASN B N   1 
ATOM   2799 C CA  . ASN B 1 119 ? 39.18786  6.45189   25.87156  1.000 34.92010  ? 119 ASN B CA  1 
ATOM   2800 C C   . ASN B 1 119 ? 39.30139  7.82614   25.24861  1.000 29.40300  ? 119 ASN B C   1 
ATOM   2801 O O   . ASN B 1 119 ? 40.38905  8.19322   24.80165  1.000 34.72880  ? 119 ASN B O   1 
ATOM   2802 C CB  . ASN B 1 119 ? 39.51986  5.37126   24.83357  1.000 28.07922  ? 119 ASN B CB  1 
ATOM   2803 C CG  . ASN B 1 119 ? 39.62806  3.99258   25.45894  1.000 33.02815  ? 119 ASN B CG  1 
ATOM   2804 O OD1 . ASN B 1 119 ? 40.67523  3.62189   25.98927  1.000 32.54796  ? 119 ASN B OD1 1 
ATOM   2805 N ND2 . ASN B 1 119 ? 38.53031  3.22775   25.42657  1.000 30.20868  ? 119 ASN B ND2 1 
ATOM   2806 N N   . PHE B 1 120 ? 38.22717  8.61421   25.25022  1.000 25.34689  ? 120 PHE B N   1 
ATOM   2807 C CA  . PHE B 1 120 ? 38.29609  9.90045   24.57530  1.000 22.21901  ? 120 PHE B CA  1 
ATOM   2808 C C   . PHE B 1 120 ? 38.67157  11.01375  25.56454  1.000 35.22407  ? 120 PHE B C   1 
ATOM   2809 O O   . PHE B 1 120 ? 38.16828  11.03608  26.68856  1.000 27.78462  ? 120 PHE B O   1 
ATOM   2810 C CB  . PHE B 1 120 ? 36.96163  10.24587  23.93283  1.000 25.66223  ? 120 PHE B CB  1 
ATOM   2811 C CG  . PHE B 1 120 ? 36.50765  9.23933   22.90041  1.000 25.53305  ? 120 PHE B CG  1 
ATOM   2812 C CD1 . PHE B 1 120 ? 37.43213  8.59515   22.08587  1.000 25.86181  ? 120 PHE B CD1 1 
ATOM   2813 C CD2 . PHE B 1 120 ? 35.15339  8.91550   22.77255  1.000 22.47690  ? 120 PHE B CD2 1 
ATOM   2814 C CE1 . PHE B 1 120 ? 37.01245  7.66582   21.11334  1.000 28.67569  ? 120 PHE B CE1 1 
ATOM   2815 C CE2 . PHE B 1 120 ? 34.74639  7.96167   21.84853  1.000 22.85706  ? 120 PHE B CE2 1 
ATOM   2816 C CZ  . PHE B 1 120 ? 35.68269  7.36274   21.00417  1.000 21.20519  ? 120 PHE B CZ  1 
ATOM   2817 N N   . PRO B 1 121 ? 39.53342  11.96971  25.16944  1.000 27.76126  ? 121 PRO B N   1 
ATOM   2818 C CA  . PRO B 1 121 ? 39.91054  13.06320  26.09253  1.000 31.22453  ? 121 PRO B CA  1 
ATOM   2819 C C   . PRO B 1 121 ? 38.86274  14.16589  26.04426  1.000 34.05528  ? 121 PRO B C   1 
ATOM   2820 O O   . PRO B 1 121 ? 38.97993  15.14196  25.32177  1.000 30.34657  ? 121 PRO B O   1 
ATOM   2821 C CB  . PRO B 1 121 ? 41.26242  13.52547  25.53679  1.000 33.05489  ? 121 PRO B CB  1 
ATOM   2822 C CG  . PRO B 1 121 ? 41.16945  13.27926  24.02259  1.000 27.74637  ? 121 PRO B CG  1 
ATOM   2823 C CD  . PRO B 1 121 ? 40.39878  11.93763  23.96562  1.000 29.92060  ? 121 PRO B CD  1 
ATOM   2824 N N   . VAL B 1 122 ? 37.79522  14.00684  26.82446  1.000 32.41401  ? 122 VAL B N   1 
ATOM   2825 C CA  . VAL B 1 122 ? 36.69228  14.97256  26.70926  1.000 35.79429  ? 122 VAL B CA  1 
ATOM   2826 C C   . VAL B 1 122 ? 37.12965  16.31275  27.30556  1.000 40.13710  ? 122 VAL B C   1 
ATOM   2827 O O   . VAL B 1 122 ? 37.59024  16.35467  28.46020  1.000 38.48652  ? 122 VAL B O   1 
ATOM   2828 C CB  . VAL B 1 122 ? 35.42854  14.43678  27.39320  1.000 34.64689  ? 122 VAL B CB  1 
ATOM   2829 C CG1 . VAL B 1 122 ? 34.30000  15.48153  27.31585  1.000 33.39194  ? 122 VAL B CG1 1 
ATOM   2830 C CG2 . VAL B 1 122 ? 34.95622  13.14185  26.70296  1.000 31.90176  ? 122 VAL B CG2 1 
ATOM   2831 N N   . PRO B 1 123 ? 37.00633  17.42666  26.57518  1.000 41.25176  ? 123 PRO B N   1 
ATOM   2832 C CA  . PRO B 1 123 ? 37.61456  18.68979  27.04775  1.000 40.70302  ? 123 PRO B CA  1 
ATOM   2833 C C   . PRO B 1 123 ? 36.94289  19.32562  28.25926  1.000 47.47381  ? 123 PRO B C   1 
ATOM   2834 O O   . PRO B 1 123 ? 37.60736  20.08990  28.96801  1.000 47.61698  ? 123 PRO B O   1 
ATOM   2835 C CB  . PRO B 1 123 ? 37.50632  19.60848  25.82595  1.000 45.94870  ? 123 PRO B CB  1 
ATOM   2836 C CG  . PRO B 1 123 ? 36.38325  19.03410  25.00272  1.000 39.89116  ? 123 PRO B CG  1 
ATOM   2837 C CD  . PRO B 1 123 ? 36.50080  17.53840  25.19736  1.000 38.02137  ? 123 PRO B CD  1 
ATOM   2838 N N   . GLU B 1 124 ? 35.66090  19.06933  28.51178  1.000 42.78323  ? 124 GLU B N   1 
ATOM   2839 C CA  . GLU B 1 124 ? 34.94105  19.68033  29.62625  1.000 42.07472  ? 124 GLU B CA  1 
ATOM   2840 C C   . GLU B 1 124 ? 34.21681  18.58498  30.39931  1.000 41.71337  ? 124 GLU B C   1 
ATOM   2841 O O   . GLU B 1 124 ? 33.40856  17.85232  29.82292  1.000 32.35798  ? 124 GLU B O   1 
ATOM   2842 C CB  . GLU B 1 124 ? 33.92906  20.72785  29.12849  1.000 39.60900  ? 124 GLU B CB  1 
ATOM   2843 C CG  . GLU B 1 124 ? 34.52068  21.97520  28.44346  1.000 46.57547  ? 124 GLU B CG  1 
ATOM   2844 C CD  . GLU B 1 124 ? 35.16694  22.94655  29.44471  1.000 52.77309  ? 124 GLU B CD  1 
ATOM   2845 O OE1 . GLU B 1 124 ? 34.60975  23.12441  30.55127  1.000 49.66043  ? 124 GLU B OE1 1 
ATOM   2846 O OE2 . GLU B 1 124 ? 36.23905  23.51638  29.13078  1.000 49.11054  ? 124 GLU B OE2 1 
ATOM   2847 N N   . GLU B 1 125 ? 34.47101  18.49007  31.70340  1.000 40.19141  ? 125 GLU B N   1 
ATOM   2848 C CA  . GLU B 1 125 ? 33.77386  17.47917  32.50181  1.000 40.01249  ? 125 GLU B CA  1 
ATOM   2849 C C   . GLU B 1 125 ? 32.25581  17.62862  32.42249  1.000 37.92276  ? 125 GLU B C   1 
ATOM   2850 O O   . GLU B 1 125 ? 31.53166  16.63589  32.51465  1.000 32.17003  ? 125 GLU B O   1 
ATOM   2851 C CB  . GLU B 1 125 ? 34.23372  17.54382  33.95064  1.000 47.41417  ? 125 GLU B CB  1 
ATOM   2852 C CG  . GLU B 1 125 ? 33.86515  16.31151  34.75929  1.000 54.65450  ? 125 GLU B CG  1 
ATOM   2853 C CD  . GLU B 1 125 ? 35.08593  15.58343  35.29960  1.000 76.85760  ? 125 GLU B CD  1 
ATOM   2854 O OE1 . GLU B 1 125 ? 36.08799  16.25921  35.64387  1.000 80.27846  ? 125 GLU B OE1 1 
ATOM   2855 O OE2 . GLU B 1 125 ? 35.04271  14.33449  35.37475  1.000 84.02593  ? 125 GLU B OE2 1 
ATOM   2856 N N   . SER B 1 126 ? 31.75620  18.84541  32.22068  1.000 29.56841  ? 126 SER B N   1 
ATOM   2857 C CA  . SER B 1 126 ? 30.31842  19.04737  32.13014  1.000 31.60032  ? 126 SER B CA  1 
ATOM   2858 C C   . SER B 1 126 ? 29.70314  18.35747  30.91322  1.000 31.66788  ? 126 SER B C   1 
ATOM   2859 O O   . SER B 1 126 ? 28.50874  18.05364  30.91269  1.000 31.06848  ? 126 SER B O   1 
ATOM   2860 C CB  . SER B 1 126 ? 30.00979  20.53824  32.06802  1.000 36.65051  ? 126 SER B CB  1 
ATOM   2861 O OG  . SER B 1 126 ? 30.49486  21.08009  30.85426  1.000 41.74328  ? 126 SER B OG  1 
ATOM   2862 N N   . TRP B 1 127 ? 30.47841  18.13981  29.85700  1.000 29.85239  ? 127 TRP B N   1 
ATOM   2863 C CA  . TRP B 1 127 ? 29.94761  17.43527  28.69501  1.000 27.70384  ? 127 TRP B CA  1 
ATOM   2864 C C   . TRP B 1 127 ? 29.51106  16.01797  29.02286  1.000 22.46751  ? 127 TRP B C   1 
ATOM   2865 O O   . TRP B 1 127 ? 28.73481  15.43127  28.26820  1.000 26.95488  ? 127 TRP B O   1 
ATOM   2866 C CB  . TRP B 1 127 ? 30.98890  17.36869  27.59576  1.000 22.77176  ? 127 TRP B CB  1 
ATOM   2867 C CG  . TRP B 1 127 ? 31.30211  18.69333  26.92931  1.000 40.41128  ? 127 TRP B CG  1 
ATOM   2868 C CD1 . TRP B 1 127 ? 30.99952  19.94474  27.38196  1.000 37.94896  ? 127 TRP B CD1 1 
ATOM   2869 C CD2 . TRP B 1 127 ? 32.00565  18.87029  25.69769  1.000 37.98606  ? 127 TRP B CD2 1 
ATOM   2870 N NE1 . TRP B 1 127 ? 31.46991  20.89099  26.50444  1.000 34.23202  ? 127 TRP B NE1 1 
ATOM   2871 C CE2 . TRP B 1 127 ? 32.09502  20.25954  25.46315  1.000 42.57753  ? 127 TRP B CE2 1 
ATOM   2872 C CE3 . TRP B 1 127 ? 32.57517  17.98461  24.76937  1.000 34.65047  ? 127 TRP B CE3 1 
ATOM   2873 C CZ2 . TRP B 1 127 ? 32.71932  20.78972  24.32890  1.000 43.09890  ? 127 TRP B CZ2 1 
ATOM   2874 C CZ3 . TRP B 1 127 ? 33.20010  18.51121  23.64679  1.000 49.46601  ? 127 TRP B CZ3 1 
ATOM   2875 C CH2 . TRP B 1 127 ? 33.26740  19.90424  23.43776  1.000 39.99055  ? 127 TRP B CH2 1 
ATOM   2876 N N   . LEU B 1 128 ? 30.03528  15.43974  30.09127  1.000 27.46640  ? 128 LEU B N   1 
ATOM   2877 C CA  . LEU B 1 128 ? 29.65654  14.08175  30.46153  1.000 30.01336  ? 128 LEU B CA  1 
ATOM   2878 C C   . LEU B 1 128 ? 28.18578  13.96856  30.88107  1.000 29.64378  ? 128 LEU B C   1 
ATOM   2879 O O   . LEU B 1 128 ? 27.62556  12.85634  30.86158  1.000 24.52381  ? 128 LEU B O   1 
ATOM   2880 C CB  . LEU B 1 128 ? 30.58197  13.60345  31.58354  1.000 26.39202  ? 128 LEU B CB  1 
ATOM   2881 C CG  . LEU B 1 128 ? 32.06910  13.53404  31.26592  1.000 31.69503  ? 128 LEU B CG  1 
ATOM   2882 C CD1 . LEU B 1 128 ? 32.79775  12.95249  32.48083  1.000 34.71727  ? 128 LEU B CD1 1 
ATOM   2883 C CD2 . LEU B 1 128 ? 32.35095  12.70103  30.03549  1.000 27.53063  ? 128 LEU B CD2 1 
ATOM   2884 N N   . ASP B 1 129 ? 27.56826  15.09005  31.26959  1.000 28.79246  ? 129 ASP B N   1 
ATOM   2885 C CA  . ASP B 1 129 ? 26.16661  15.21238  31.65342  1.000 31.31655  ? 129 ASP B CA  1 
ATOM   2886 C C   . ASP B 1 129 ? 25.27903  15.62826  30.50988  1.000 34.40010  ? 129 ASP B C   1 
ATOM   2887 O O   . ASP B 1 129 ? 24.06678  15.74061  30.69974  1.000 35.30891  ? 129 ASP B O   1 
ATOM   2888 C CB  . ASP B 1 129 ? 26.00211  16.25934  32.74919  1.000 36.30193  ? 129 ASP B CB  1 
ATOM   2889 C CG  . ASP B 1 129 ? 26.68360  15.85588  34.00024  1.000 40.50582  ? 129 ASP B CG  1 
ATOM   2890 O OD1 . ASP B 1 129 ? 26.38748  14.72108  34.42594  1.000 40.59779  ? 129 ASP B OD1 1 
ATOM   2891 O OD2 . ASP B 1 129 ? 27.51743  16.63577  34.52829  1.000 40.79389  ? 129 ASP B OD2 1 
ATOM   2892 N N   . ASP B 1 130 ? 25.84797  15.90699  29.35990  1.000 30.82471  ? 130 ASP B N   1 
ATOM   2893 C CA  . ASP B 1 130 ? 25.02046  16.26586  28.22384  1.000 29.75396  ? 130 ASP B CA  1 
ATOM   2894 C C   . ASP B 1 130 ? 24.77998  15.06058  27.33016  1.000 25.93286  ? 130 ASP B C   1 
ATOM   2895 O O   . ASP B 1 130 ? 25.53608  14.08392  27.36378  1.000 23.14793  ? 130 ASP B O   1 
ATOM   2896 C CB  . ASP B 1 130 ? 25.68892  17.35824  27.39388  1.000 28.50170  ? 130 ASP B CB  1 
ATOM   2897 C CG  . ASP B 1 130 ? 25.96756  18.61661  28.18071  1.000 35.87629  ? 130 ASP B CG  1 
ATOM   2898 O OD1 . ASP B 1 130 ? 25.21724  18.89727  29.14777  1.000 35.60196  ? 130 ASP B OD1 1 
ATOM   2899 O OD2 . ASP B 1 130 ? 26.93571  19.32703  27.80816  1.000 29.81183  ? 130 ASP B OD2 1 
ATOM   2900 N N   . PRO B 1 131 ? 23.74313  15.11568  26.50217  1.000 26.65527  ? 131 PRO B N   1 
ATOM   2901 C CA  . PRO B 1 131 ? 23.57857  14.10034  25.46610  1.000 23.37376  ? 131 PRO B CA  1 
ATOM   2902 C C   . PRO B 1 131 ? 24.66832  14.17829  24.40667  1.000 25.20185  ? 131 PRO B C   1 
ATOM   2903 O O   . PRO B 1 131 ? 25.24384  15.24020  24.11385  1.000 25.18147  ? 131 PRO B O   1 
ATOM   2904 C CB  . PRO B 1 131 ? 22.21644  14.43152  24.84892  1.000 23.82523  ? 131 PRO B CB  1 
ATOM   2905 C CG  . PRO B 1 131 ? 21.50277  15.24315  25.88840  1.000 25.39149  ? 131 PRO B CG  1 
ATOM   2906 C CD  . PRO B 1 131 ? 22.59680  16.04253  26.54194  1.000 25.25449  ? 131 PRO B CD  1 
ATOM   2907 N N   . TRP B 1 132 ? 24.93041  13.01981  23.83200  1.000 23.53165  ? 132 TRP B N   1 
ATOM   2908 C CA  . TRP B 1 132 ? 25.78030  12.83779  22.67171  1.000 22.06620  ? 132 TRP B CA  1 
ATOM   2909 C C   . TRP B 1 132 ? 25.00200  12.02679  21.64853  1.000 23.19525  ? 132 TRP B C   1 
ATOM   2910 O O   . TRP B 1 132 ? 24.19284  11.14899  22.00206  1.000 19.79766  ? 132 TRP B O   1 
ATOM   2911 C CB  . TRP B 1 132 ? 27.06818  12.10155  23.01929  1.000 19.91205  ? 132 TRP B CB  1 
ATOM   2912 C CG  . TRP B 1 132 ? 27.99082  12.84521  23.91316  1.000 24.02227  ? 132 TRP B CG  1 
ATOM   2913 C CD1 . TRP B 1 132 ? 27.73116  13.28176  25.18265  1.000 21.91927  ? 132 TRP B CD1 1 
ATOM   2914 C CD2 . TRP B 1 132 ? 29.34442  13.22465  23.62744  1.000 22.95929  ? 132 TRP B CD2 1 
ATOM   2915 N NE1 . TRP B 1 132 ? 28.84173  13.88636  25.70376  1.000 19.99498  ? 132 TRP B NE1 1 
ATOM   2916 C CE2 . TRP B 1 132 ? 29.84561  13.86385  24.77316  1.000 19.19862  ? 132 TRP B CE2 1 
ATOM   2917 C CE3 . TRP B 1 132 ? 30.18670  13.05223  22.52467  1.000 23.02317  ? 132 TRP B CE3 1 
ATOM   2918 C CZ2 . TRP B 1 132 ? 31.14301  14.35625  24.84965  1.000 24.61312  ? 132 TRP B CZ2 1 
ATOM   2919 C CZ3 . TRP B 1 132 ? 31.48022  13.54517  22.58965  1.000 20.91896  ? 132 TRP B CZ3 1 
ATOM   2920 C CH2 . TRP B 1 132 ? 31.94438  14.20785  23.74441  1.000 30.41926  ? 132 TRP B CH2 1 
ATOM   2921 N N   . ASP B 1 133 ? 25.22898  12.34028  20.38013  1.000 22.10756  ? 133 ASP B N   1 
ATOM   2922 C CA  . ASP B 1 133 ? 24.69142  11.54307  19.29396  1.000 23.47625  ? 133 ASP B CA  1 
ATOM   2923 C C   . ASP B 1 133 ? 25.78920  10.55753  18.94256  1.000 21.38146  ? 133 ASP B C   1 
ATOM   2924 O O   . ASP B 1 133 ? 26.94843  10.95430  18.78782  1.000 18.45458  ? 133 ASP B O   1 
ATOM   2925 C CB  . ASP B 1 133 ? 24.30793  12.42476  18.09768  1.000 21.03892  ? 133 ASP B CB  1 
ATOM   2926 C CG  . ASP B 1 133 ? 23.80267  11.61605  16.90345  1.000 30.27869  ? 133 ASP B CG  1 
ATOM   2927 O OD1 . ASP B 1 133 ? 22.91425  10.75364  17.06184  1.000 28.12030  ? 133 ASP B OD1 1 
ATOM   2928 O OD2 . ASP B 1 133 ? 24.31294  11.82670  15.78363  1.000 37.41541  ? 133 ASP B OD2 1 
ATOM   2929 N N   . VAL B 1 134 ? 25.44988  9.27411   18.89857  1.000 17.79537  ? 134 VAL B N   1 
ATOM   2930 C CA  . VAL B 1 134 ? 26.42405  8.23887   18.58022  1.000 13.79080  ? 134 VAL B CA  1 
ATOM   2931 C C   . VAL B 1 134 ? 25.94993  7.52796   17.32691  1.000 22.08414  ? 134 VAL B C   1 
ATOM   2932 O O   . VAL B 1 134 ? 24.89211  6.87115   17.33492  1.000 21.95571  ? 134 VAL B O   1 
ATOM   2933 C CB  . VAL B 1 134 ? 26.64440  7.24614   19.72641  1.000 18.87093  ? 134 VAL B CB  1 
ATOM   2934 C CG1 . VAL B 1 134 ? 27.77483  6.24329   19.30319  1.000 16.38906  ? 134 VAL B CG1 1 
ATOM   2935 C CG2 . VAL B 1 134 ? 27.04544  7.97874   21.01491  1.000 19.26090  ? 134 VAL B CG2 1 
ATOM   2936 N N   . GLN B 1 135 ? 26.68701  7.71934   16.22251  1.000 22.23998  ? 135 GLN B N   1 
ATOM   2937 C CA  . GLN B 1 135 ? 26.40876  6.98286   14.99047  1.000 22.30642  ? 135 GLN B CA  1 
ATOM   2938 C C   . GLN B 1 135 ? 27.08157  5.62638   15.07192  1.000 21.54931  ? 135 GLN B C   1 
ATOM   2939 O O   . GLN B 1 135 ? 28.21988  5.53789   15.51088  1.000 18.40439  ? 135 GLN B O   1 
ATOM   2940 C CB  . GLN B 1 135 ? 26.94025  7.74505   13.77500  1.000 23.90187  ? 135 GLN B CB  1 
ATOM   2941 C CG  . GLN B 1 135 ? 26.14180  8.97442   13.43028  1.000 25.86307  ? 135 GLN B CG  1 
ATOM   2942 C CD  . GLN B 1 135 ? 26.84392  9.76101   12.38185  1.000 34.79293  ? 135 GLN B CD  1 
ATOM   2943 O OE1 . GLN B 1 135 ? 27.00319  9.29210   11.26077  1.000 37.48129  ? 135 GLN B OE1 1 
ATOM   2944 N NE2 . GLN B 1 135 ? 27.37098  10.91370  12.75707  1.000 36.47622  ? 135 GLN B NE2 1 
ATOM   2945 N N   . CYS B 1 136 ? 26.37292  4.56317   14.66080  1.000 20.99099  ? 136 CYS B N   1 
ATOM   2946 C CA  . CYS B 1 136 ? 26.91241  3.21021   14.74709  1.000 20.50666  ? 136 CYS B CA  1 
ATOM   2947 C C   . CYS B 1 136 ? 26.78863  2.54910   13.38439  1.000 23.95785  ? 136 CYS B C   1 
ATOM   2948 O O   . CYS B 1 136 ? 25.66454  2.34499   12.90334  1.000 20.11793  ? 136 CYS B O   1 
ATOM   2949 C CB  . CYS B 1 136 ? 26.17151  2.41229   15.80368  1.000 21.16724  ? 136 CYS B CB  1 
ATOM   2950 S SG  . CYS B 1 136 ? 26.71077  0.71936   15.97186  1.000 29.74271  ? 136 CYS B SG  1 
ATOM   2951 N N   . HIS B 1 137 ? 27.92654  2.23700   12.75502  1.000 17.84767  ? 137 HIS B N   1 
ATOM   2952 C CA  . HIS B 1 137 ? 27.94867  1.74058   11.38283  1.000 20.05485  ? 137 HIS B CA  1 
ATOM   2953 C C   . HIS B 1 137 ? 28.56136  0.35457   11.31257  1.000 18.76304  ? 137 HIS B C   1 
ATOM   2954 O O   . HIS B 1 137 ? 29.68601  0.14080   11.79105  1.000 16.87735  ? 137 HIS B O   1 
ATOM   2955 C CB  . HIS B 1 137 ? 28.74200  2.67693   10.46435  1.000 21.40886  ? 137 HIS B CB  1 
ATOM   2956 C CG  . HIS B 1 137 ? 28.03531  3.95764   10.15322  1.000 25.90723  ? 137 HIS B CG  1 
ATOM   2957 N ND1 . HIS B 1 137 ? 27.39584  4.18669   8.95165   1.000 28.42347  ? 137 HIS B ND1 1 
ATOM   2958 C CD2 . HIS B 1 137 ? 27.85108  5.07320   10.89387  1.000 36.06498  ? 137 HIS B CD2 1 
ATOM   2959 C CE1 . HIS B 1 137 ? 26.84955  5.38729   8.96617   1.000 35.49129  ? 137 HIS B CE1 1 
ATOM   2960 N NE2 . HIS B 1 137 ? 27.11368  5.94957   10.13127  1.000 38.35487  ? 137 HIS B NE2 1 
ATOM   2961 N N   . GLN B 1 138 ? 27.84906  -0.57105  10.66788  1.000 14.69032  ? 138 GLN B N   1 
ATOM   2962 C CA  . GLN B 1 138 ? 28.42081  -1.85234  10.26986  1.000 18.74110  ? 138 GLN B CA  1 
ATOM   2963 C C   . GLN B 1 138 ? 28.75090  -1.74715  8.78687   1.000 22.09426  ? 138 GLN B C   1 
ATOM   2964 O O   . GLN B 1 138 ? 27.85148  -1.48637  7.98091   1.000 20.45893  ? 138 GLN B O   1 
ATOM   2965 C CB  . GLN B 1 138 ? 27.43278  -3.00190  10.48272  1.000 22.08637  ? 138 GLN B CB  1 
ATOM   2966 C CG  . GLN B 1 138 ? 27.06784  -3.27289  11.94595  1.000 24.65160  ? 138 GLN B CG  1 
ATOM   2967 C CD  . GLN B 1 138 ? 26.00634  -4.33536  12.05924  1.000 22.26945  ? 138 GLN B CD  1 
ATOM   2968 O OE1 . GLN B 1 138 ? 24.91401  -4.21458  11.46230  1.000 22.67847  ? 138 GLN B OE1 1 
ATOM   2969 N NE2 . GLN B 1 138 ? 26.31379  -5.39178  12.78052  1.000 22.38439  ? 138 GLN B NE2 1 
ATOM   2970 N N   . PHE B 1 139 ? 30.02452  -1.91338  8.42356   1.000 21.62303  ? 139 PHE B N   1 
ATOM   2971 C CA  . PHE B 1 139 ? 30.43237  -1.90621  7.01786   1.000 22.87047  ? 139 PHE B CA  1 
ATOM   2972 C C   . PHE B 1 139 ? 31.08097  -3.23689  6.67773   1.000 24.63497  ? 139 PHE B C   1 
ATOM   2973 O O   . PHE B 1 139 ? 31.94638  -3.70445  7.41398   1.000 20.66389  ? 139 PHE B O   1 
ATOM   2974 C CB  . PHE B 1 139 ? 31.42964  -0.79603  6.70049   1.000 23.01114  ? 139 PHE B CB  1 
ATOM   2975 C CG  . PHE B 1 139 ? 30.85086  0.59412   6.72627   1.000 25.02808  ? 139 PHE B CG  1 
ATOM   2976 C CD1 . PHE B 1 139 ? 29.78606  0.94248   5.91302   1.000 28.15965  ? 139 PHE B CD1 1 
ATOM   2977 C CD2 . PHE B 1 139 ? 31.41204  1.56864   7.53251   1.000 25.62401  ? 139 PHE B CD2 1 
ATOM   2978 C CE1 . PHE B 1 139 ? 29.27261  2.24681   5.91155   1.000 28.38083  ? 139 PHE B CE1 1 
ATOM   2979 C CE2 . PHE B 1 139 ? 30.90057  2.87060   7.53831   1.000 30.40904  ? 139 PHE B CE2 1 
ATOM   2980 C CZ  . PHE B 1 139 ? 29.82840  3.20012   6.73340   1.000 33.16205  ? 139 PHE B CZ  1 
ATOM   2981 N N   . ARG B 1 140 ? 30.67359  -3.83691  5.55894   1.000 23.49476  ? 140 ARG B N   1 
ATOM   2982 C CA  . ARG B 1 140 ? 31.41985  -4.92945  4.93027   1.000 21.40294  ? 140 ARG B CA  1 
ATOM   2983 C C   . ARG B 1 140 ? 31.88834  -4.42645  3.57483   1.000 26.17040  ? 140 ARG B C   1 
ATOM   2984 O O   . ARG B 1 140 ? 31.06370  -4.04654  2.73354   1.000 22.90788  ? 140 ARG B O   1 
ATOM   2985 C CB  . ARG B 1 140 ? 30.57381  -6.18837  4.74539   1.000 22.81109  ? 140 ARG B CB  1 
ATOM   2986 C CG  . ARG B 1 140 ? 31.23296  -7.20813  3.75026   1.000 26.77522  ? 140 ARG B CG  1 
ATOM   2987 C CD  . ARG B 1 140 ? 30.54449  -8.54398  3.80442   1.000 24.91506  ? 140 ARG B CD  1 
ATOM   2988 N NE  . ARG B 1 140 ? 31.05759  -9.28236  4.94527   1.000 26.57212  ? 140 ARG B NE  1 
ATOM   2989 C CZ  . ARG B 1 140 ? 30.86848  -10.57720 5.14155   1.000 33.75674  ? 140 ARG B CZ  1 
ATOM   2990 N NH1 . ARG B 1 140 ? 30.13262  -11.30198 4.30300   1.000 33.94274  ? 140 ARG B NH1 1 
ATOM   2991 N NH2 . ARG B 1 140 ? 31.43528  -11.16418 6.20242   1.000 30.65239  ? 140 ARG B NH2 1 
ATOM   2992 N N   . ILE B 1 141 ? 33.19969  -4.38990  3.38627   1.000 22.81235  ? 141 ILE B N   1 
ATOM   2993 C CA  . ILE B 1 141 ? 33.82824  -3.83530  2.19399   1.000 24.41677  ? 141 ILE B CA  1 
ATOM   2994 C C   . ILE B 1 141 ? 34.30742  -5.01765  1.37041   1.000 24.64972  ? 141 ILE B C   1 
ATOM   2995 O O   . ILE B 1 141 ? 34.97475  -5.91188  1.90177   1.000 25.92808  ? 141 ILE B O   1 
ATOM   2996 C CB  . ILE B 1 141 ? 34.98935  -2.89499  2.56855   1.000 28.08979  ? 141 ILE B CB  1 
ATOM   2997 C CG1 . ILE B 1 141 ? 34.47759  -1.63755  3.30861   1.000 34.32129  ? 141 ILE B CG1 1 
ATOM   2998 C CG2 . ILE B 1 141 ? 35.75906  -2.45458  1.35924   1.000 36.49915  ? 141 ILE B CG2 1 
ATOM   2999 C CD1 . ILE B 1 141 ? 34.41250  -1.82063  4.82641   1.000 36.90069  ? 141 ILE B CD1 1 
ATOM   3000 N N   . ILE B 1 142 ? 33.97481  -5.03537  0.07995   1.000 28.66164  ? 142 ILE B N   1 
ATOM   3001 C CA  . ILE B 1 142 ? 34.23976  -6.19688  -0.77401  1.000 31.53489  ? 142 ILE B CA  1 
ATOM   3002 C C   . ILE B 1 142 ? 35.01834  -5.76165  -2.01052  1.000 31.66792  ? 142 ILE B C   1 
ATOM   3003 O O   . ILE B 1 142 ? 34.63750  -4.79863  -2.68407  1.000 36.57838  ? 142 ILE B O   1 
ATOM   3004 C CB  . ILE B 1 142 ? 32.93788  -6.89468  -1.20710  1.000 31.92955  ? 142 ILE B CB  1 
ATOM   3005 C CG1 . ILE B 1 142 ? 32.20263  -7.50512  0.00673   1.000 28.10960  ? 142 ILE B CG1 1 
ATOM   3006 C CG2 . ILE B 1 142 ? 33.24292  -7.91312  -2.32361  1.000 29.50810  ? 142 ILE B CG2 1 
ATOM   3007 C CD1 . ILE B 1 142 ? 30.75055  -6.97704  0.12625   1.000 30.22071  ? 142 ILE B CD1 1 
ATOM   3008 N N   . SER B 1 143 ? 36.06952  -6.49805  -2.33872  1.000 30.28259  ? 143 SER B N   1 
ATOM   3009 C CA  . SER B 1 143 ? 36.89835  -6.18677  -3.50226  1.000 36.76218  ? 143 SER B CA  1 
ATOM   3010 C C   . SER B 1 143 ? 37.02427  -7.46236  -4.32388  1.000 31.11179  ? 143 SER B C   1 
ATOM   3011 O O   . SER B 1 143 ? 37.58117  -8.45159  -3.83611  1.000 34.07230  ? 143 SER B O   1 
ATOM   3012 C CB  . SER B 1 143 ? 38.26383  -5.67996  -3.04325  1.000 39.11124  ? 143 SER B CB  1 
ATOM   3013 O OG  . SER B 1 143 ? 39.08368  -5.28087  -4.11118  1.000 43.82918  ? 143 SER B OG  1 
ATOM   3014 N N   . THR B 1 144 ? 36.43835  -7.47305  -5.55495  1.000 28.79011  ? 144 THR B N   1 
ATOM   3015 C CA  . THR B 1 144 ? 36.51315  -8.67828  -6.38731  1.000 35.42591  ? 144 THR B CA  1 
ATOM   3016 C C   . THR B 1 144 ? 37.73155  -8.59828  -7.32144  1.000 42.04894  ? 144 THR B C   1 
ATOM   3017 O O   . THR B 1 144 ? 38.28926  -7.51470  -7.53191  1.000 43.05252  ? 144 THR B O   1 
ATOM   3018 C CB  . THR B 1 144 ? 35.20544  -8.85751  -7.18902  1.000 38.36037  ? 144 THR B CB  1 
ATOM   3019 O OG1 . THR B 1 144 ? 35.09538  -7.84222  -8.18473  1.000 38.43621  ? 144 THR B OG1 1 
ATOM   3020 C CG2 . THR B 1 144 ? 33.98548  -8.74829  -6.30838  1.000 38.01394  ? 144 THR B CG2 1 
ATOM   3021 N N   . PRO B 1 145 ? 38.21359  -9.75760  -7.86837  1.000 45.12741  ? 145 PRO B N   1 
ATOM   3022 C CA  . PRO B 1 145 ? 39.43532  -9.76399  -8.70825  1.000 45.85999  ? 145 PRO B CA  1 
ATOM   3023 C C   . PRO B 1 145 ? 39.60371  -8.59460  -9.67634  1.000 55.68009  ? 145 PRO B C   1 
ATOM   3024 O O   . PRO B 1 145 ? 38.79716  -8.38379  -10.58890 1.000 49.51988  ? 145 PRO B O   1 
ATOM   3025 C CB  . PRO B 1 145 ? 39.30460  -11.08906 -9.44960  1.000 49.45284  ? 145 PRO B CB  1 
ATOM   3026 C CG  . PRO B 1 145 ? 38.72430  -11.99609 -8.35294  1.000 45.29448  ? 145 PRO B CG  1 
ATOM   3027 C CD  . PRO B 1 145 ? 37.71821  -11.13082 -7.62402  1.000 40.26144  ? 145 PRO B CD  1 
ATOM   3028 N N   . ASP B 1 146 ? 40.70540  -7.85948  -9.47985  1.000 70.86619  ? 146 ASP B N   1 
ATOM   3029 C CA  . ASP B 1 146 ? 40.78342  -6.42946  -9.78994  1.000 77.78992  ? 146 ASP B CA  1 
ATOM   3030 C C   . ASP B 1 146 ? 40.88573  -6.15836  -11.28367 1.000 82.98418  ? 146 ASP B C   1 
ATOM   3031 O O   . ASP B 1 146 ? 41.87771  -6.52935  -11.92282 1.000 79.87606  ? 146 ASP B O   1 
ATOM   3032 C CB  . ASP B 1 146 ? 41.98739  -5.80566  -9.08038  1.000 67.73752  ? 146 ASP B CB  1 
ATOM   3033 C CG  . ASP B 1 146 ? 41.63681  -5.23845  -7.72604  1.000 69.55286  ? 146 ASP B CG  1 
ATOM   3034 O OD1 . ASP B 1 146 ? 41.29223  -6.03214  -6.82478  1.000 60.75896  ? 146 ASP B OD1 1 
ATOM   3035 O OD2 . ASP B 1 146 ? 41.70346  -3.99881  -7.56167  1.000 72.31771  ? 146 ASP B OD2 1 
ATOM   3036 N N   . GLU B 1 147 ? 39.89262  -5.45114  -11.82152 1.000 91.22171  ? 147 GLU B N   1 
ATOM   3037 C CA  . GLU B 1 147 ? 40.00315  -4.87598  -13.16415 1.000 101.01904 ? 147 GLU B CA  1 
ATOM   3038 C C   . GLU B 1 147 ? 39.47840  -3.43757  -13.19684 1.000 91.80583  ? 147 GLU B C   1 
ATOM   3039 O O   . GLU B 1 147 ? 40.22944  -2.48830  -12.94974 1.000 92.67458  ? 147 GLU B O   1 
ATOM   3040 C CB  . GLU B 1 147 ? 39.26383  -5.74082  -14.19630 1.000 99.13213  ? 147 GLU B CB  1 
ATOM   3041 C CG  . GLU B 1 147 ? 39.97203  -7.06016  -14.53024 1.000 89.63123  ? 147 GLU B CG  1 
ATOM   3042 C CD  . GLU B 1 147 ? 41.45763  -6.87460  -14.84019 1.000 95.57266  ? 147 GLU B CD  1 
ATOM   3043 O OE1 . GLU B 1 147 ? 41.81335  -5.89821  -15.53566 1.000 93.32209  ? 147 GLU B OE1 1 
ATOM   3044 O OE2 . GLU B 1 147 ? 42.27436  -7.70028  -14.37243 1.000 94.89017  ? 147 GLU B OE2 1 
ATOM   3045 N N   . GLU B 1 154 ? 38.90973  7.91520   -0.90478  1.000 55.90786  ? 154 GLU B N   1 
ATOM   3046 C CA  . GLU B 1 154 ? 40.22590  7.28151   -0.77042  1.000 56.85310  ? 154 GLU B CA  1 
ATOM   3047 C C   . GLU B 1 154 ? 41.22864  8.32358   -0.28644  1.000 57.80777  ? 154 GLU B C   1 
ATOM   3048 O O   . GLU B 1 154 ? 42.31465  7.97795   0.20014   1.000 57.78502  ? 154 GLU B O   1 
ATOM   3049 C CB  . GLU B 1 154 ? 40.68667  6.64904   -2.11332  1.000 58.55290  ? 154 GLU B CB  1 
ATOM   3050 C CG  . GLU B 1 154 ? 42.09810  6.01118   -2.09466  1.000 57.91606  ? 154 GLU B CG  1 
ATOM   3051 C CD  . GLU B 1 154 ? 42.66602  5.70119   -3.50108  1.000 61.52017  ? 154 GLU B CD  1 
ATOM   3052 O OE1 . GLU B 1 154 ? 41.87266  5.49996   -4.45574  1.000 60.54858  ? 154 GLU B OE1 1 
ATOM   3053 O OE2 . GLU B 1 154 ? 43.91322  5.64258   -3.64775  1.000 54.74214  ? 154 GLU B OE2 1 
ATOM   3054 N N   . GLY B 1 155 ? 40.86683  9.60364   -0.42470  1.000 59.04727  ? 155 GLY B N   1 
ATOM   3055 C CA  . GLY B 1 155 ? 41.71267  10.68795  0.02440   1.000 51.38665  ? 155 GLY B CA  1 
ATOM   3056 C C   . GLY B 1 155 ? 41.38811  11.07630  1.45114   1.000 48.82855  ? 155 GLY B C   1 
ATOM   3057 O O   . GLY B 1 155 ? 40.30507  10.78407  1.96240   1.000 46.09538  ? 155 GLY B O   1 
ATOM   3058 N N   . PRO B 1 156 ? 42.32231  11.74144  2.12434   1.000 52.04547  ? 156 PRO B N   1 
ATOM   3059 C CA  . PRO B 1 156 ? 42.11531  12.05774  3.54593   1.000 39.75987  ? 156 PRO B CA  1 
ATOM   3060 C C   . PRO B 1 156 ? 40.92046  12.98025  3.75312   1.000 48.25602  ? 156 PRO B C   1 
ATOM   3061 O O   . PRO B 1 156 ? 40.59472  13.81637  2.89906   1.000 44.07440  ? 156 PRO B O   1 
ATOM   3062 C CB  . PRO B 1 156 ? 43.43317  12.72956  3.96585   1.000 47.81093  ? 156 PRO B CB  1 
ATOM   3063 C CG  . PRO B 1 156 ? 44.10977  13.14194  2.67401   1.000 48.94416  ? 156 PRO B CG  1 
ATOM   3064 C CD  . PRO B 1 156 ? 43.62469  12.20312  1.60543   1.000 48.11872  ? 156 PRO B CD  1 
ATOM   3065 N N   . HIS B 1 157 ? 40.27093  12.82629  4.91669   1.000 39.00161  ? 157 HIS B N   1 
ATOM   3066 C CA  . HIS B 1 157 ? 39.03300  13.54501  5.21915   1.000 35.36028  ? 157 HIS B CA  1 
ATOM   3067 C C   . HIS B 1 157 ? 38.64605  13.33102  6.68268   1.000 34.06514  ? 157 HIS B C   1 
ATOM   3068 O O   . HIS B 1 157 ? 39.30449  12.58453  7.42675   1.000 30.30158  ? 157 HIS B O   1 
ATOM   3069 C CB  . HIS B 1 157 ? 37.91078  13.03801  4.33909   1.000 41.48710  ? 157 HIS B CB  1 
ATOM   3070 C CG  . HIS B 1 157 ? 37.54811  11.63099  4.66179   1.000 42.03723  ? 157 HIS B CG  1 
ATOM   3071 N ND1 . HIS B 1 157 ? 38.32918  10.56738  4.27394   1.000 40.11310  ? 157 HIS B ND1 1 
ATOM   3072 C CD2 . HIS B 1 157 ? 36.55160  11.11558  5.42061   1.000 39.78624  ? 157 HIS B CD2 1 
ATOM   3073 C CE1 . HIS B 1 157 ? 37.79626  9.44675   4.72857   1.000 44.97177  ? 157 HIS B CE1 1 
ATOM   3074 N NE2 . HIS B 1 157 ? 36.72232  9.75469   5.43240   1.000 35.37181  ? 157 HIS B NE2 1 
ATOM   3075 N N   . ARG B 1 158 ? 37.52412  13.96377  7.06317   1.000 36.32761  ? 158 ARG B N   1 
ATOM   3076 C CA  . ARG B 1 158 ? 36.87715  13.87754  8.37816   1.000 36.00093  ? 158 ARG B CA  1 
ATOM   3077 C C   . ARG B 1 158 ? 35.56040  13.13139  8.27274   1.000 34.20585  ? 158 ARG B C   1 
ATOM   3078 O O   . ARG B 1 158 ? 34.90350  13.19381  7.23476   1.000 32.80841  ? 158 ARG B O   1 
ATOM   3079 C CB  . ARG B 1 158 ? 36.47367  15.24139  8.92426   1.000 39.09394  ? 158 ARG B CB  1 
ATOM   3080 C CG  . ARG B 1 158 ? 37.46829  16.07394  9.52797   1.000 45.01620  ? 158 ARG B CG  1 
ATOM   3081 C CD  . ARG B 1 158 ? 36.68339  17.20370  10.12324  1.000 43.93601  ? 158 ARG B CD  1 
ATOM   3082 N NE  . ARG B 1 158 ? 36.02948  16.75790  11.34347  1.000 38.13323  ? 158 ARG B NE  1 
ATOM   3083 C CZ  . ARG B 1 158 ? 35.78047  17.55551  12.36609  1.000 39.31016  ? 158 ARG B CZ  1 
ATOM   3084 N NH1 . ARG B 1 158 ? 36.00161  18.85781  12.29070  1.000 41.14970  ? 158 ARG B NH1 1 
ATOM   3085 N NH2 . ARG B 1 158 ? 35.33892  17.03373  13.50156  1.000 27.73873  ? 158 ARG B NH2 1 
ATOM   3086 N N   . ASP B 1 159 ? 35.11029  12.53080  9.39426   1.000 33.30669  ? 159 ASP B N   1 
ATOM   3087 C CA  . ASP B 1 159 ? 33.73471  12.04021  9.46971   1.000 31.10171  ? 159 ASP B CA  1 
ATOM   3088 C C   . ASP B 1 159 ? 32.76336  13.07557  10.02988  1.000 33.03272  ? 159 ASP B C   1 
ATOM   3089 O O   . ASP B 1 159 ? 31.55673  12.81536  10.04550  1.000 36.99286  ? 159 ASP B O   1 
ATOM   3090 C CB  . ASP B 1 159 ? 33.64011  10.75139  10.31500  1.000 28.17505  ? 159 ASP B CB  1 
ATOM   3091 C CG  . ASP B 1 159 ? 34.35322  9.57718   9.66605   1.000 38.86772  ? 159 ASP B CG  1 
ATOM   3092 O OD1 . ASP B 1 159 ? 34.78296  9.73900   8.51130   1.000 32.34044  ? 159 ASP B OD1 1 
ATOM   3093 O OD2 . ASP B 1 159 ? 34.49004  8.50336   10.30083  1.000 39.32358  ? 159 ASP B OD2 1 
ATOM   3094 N N   . GLU B 1 160 ? 33.24578  14.22920  10.50315  1.000 30.36430  ? 160 GLU B N   1 
ATOM   3095 C CA  . GLU B 1 160 ? 32.36623  15.28996  11.01533  1.000 31.19270  ? 160 GLU B CA  1 
ATOM   3096 C C   . GLU B 1 160 ? 31.72251  14.90775  12.36008  1.000 32.76635  ? 160 GLU B C   1 
ATOM   3097 O O   . GLU B 1 160 ? 30.54748  15.16382  12.61165  1.000 35.44201  ? 160 GLU B O   1 
ATOM   3098 C CB  . GLU B 1 160 ? 31.29152  15.67427  9.98973   1.000 33.55213  ? 160 GLU B CB  1 
ATOM   3099 C CG  . GLU B 1 160 ? 31.84243  16.07509  8.60878   1.000 42.48801  ? 160 GLU B CG  1 
ATOM   3100 C CD  . GLU B 1 160 ? 32.76332  17.29935  8.65885   1.000 50.73601  ? 160 GLU B CD  1 
ATOM   3101 O OE1 . GLU B 1 160 ? 32.73866  18.05860  9.65870   1.000 45.64124  ? 160 GLU B OE1 1 
ATOM   3102 O OE2 . GLU B 1 160 ? 33.51594  17.50432  7.67963   1.000 54.08060  ? 160 GLU B OE2 1 
ATOM   3103 N N   . VAL B 1 161 ? 32.50348  14.31511  13.23715  1.000 25.68885  ? 161 VAL B N   1 
ATOM   3104 C CA  . VAL B 1 161 ? 32.07829  13.99560  14.58483  1.000 26.31052  ? 161 VAL B CA  1 
ATOM   3105 C C   . VAL B 1 161 ? 33.16271  14.50438  15.50549  1.000 27.05320  ? 161 VAL B C   1 
ATOM   3106 O O   . VAL B 1 161 ? 34.17568  15.01636  15.04140  1.000 27.38190  ? 161 VAL B O   1 
ATOM   3107 C CB  . VAL B 1 161 ? 31.86296  12.48655  14.79681  1.000 22.77673  ? 161 VAL B CB  1 
ATOM   3108 C CG1 . VAL B 1 161 ? 30.70894  11.97400  13.91121  1.000 22.62822  ? 161 VAL B CG1 1 
ATOM   3109 C CG2 . VAL B 1 161 ? 33.16839  11.73509  14.54325  1.000 23.86384  ? 161 VAL B CG2 1 
ATOM   3110 N N   . ASP B 1 162 ? 32.97434  14.31910  16.81086  1.000 25.22068  ? 162 ASP B N   1 
ATOM   3111 C CA  . ASP B 1 162 ? 34.02990  14.71486  17.72538  1.000 26.35410  ? 162 ASP B CA  1 
ATOM   3112 C C   . ASP B 1 162 ? 35.06901  13.61425  17.90405  1.000 28.14187  ? 162 ASP B C   1 
ATOM   3113 O O   . ASP B 1 162 ? 36.27080  13.87814  17.88727  1.000 24.91294  ? 162 ASP B O   1 
ATOM   3114 C CB  . ASP B 1 162 ? 33.41587  15.11618  19.07267  1.000 30.05082  ? 162 ASP B CB  1 
ATOM   3115 C CG  . ASP B 1 162 ? 32.65616  16.44249  18.98020  1.000 36.56303  ? 162 ASP B CG  1 
ATOM   3116 O OD1 . ASP B 1 162 ? 33.14754  17.35394  18.27919  1.000 41.99111  ? 162 ASP B OD1 1 
ATOM   3117 O OD2 . ASP B 1 162 ? 31.56474  16.56378  19.55248  1.000 27.29782  ? 162 ASP B OD2 1 
ATOM   3118 N N   . PHE B 1 163 ? 34.63195  12.37566  18.07773  1.000 27.19805  ? 163 PHE B N   1 
ATOM   3119 C CA  . PHE B 1 163 ? 35.53079  11.27010  18.33552  1.000 24.80931  ? 163 PHE B CA  1 
ATOM   3120 C C   . PHE B 1 163 ? 35.00686  10.05532  17.59745  1.000 25.54521  ? 163 PHE B C   1 
ATOM   3121 O O   . PHE B 1 163 ? 33.78812  9.88496   17.44520  1.000 21.12462  ? 163 PHE B O   1 
ATOM   3122 C CB  . PHE B 1 163 ? 35.64938  10.92404  19.82485  1.000 24.30006  ? 163 PHE B CB  1 
ATOM   3123 C CG  . PHE B 1 163 ? 36.20339  12.04283  20.67450  1.000 24.25350  ? 163 PHE B CG  1 
ATOM   3124 C CD1 . PHE B 1 163 ? 37.55741  12.37531  20.62108  1.000 28.43104  ? 163 PHE B CD1 1 
ATOM   3125 C CD2 . PHE B 1 163 ? 35.37428  12.74558  21.53366  1.000 24.89284  ? 163 PHE B CD2 1 
ATOM   3126 C CE1 . PHE B 1 163 ? 38.06251  13.38649  21.41231  1.000 27.58289  ? 163 PHE B CE1 1 
ATOM   3127 C CE2 . PHE B 1 163 ? 35.86612  13.76771  22.31643  1.000 30.14836  ? 163 PHE B CE2 1 
ATOM   3128 C CZ  . PHE B 1 163 ? 37.22093  14.08665  22.26783  1.000 28.18615  ? 163 PHE B CZ  1 
ATOM   3129 N N   . GLY B 1 164 ? 35.94185  9.21225   17.15040  1.000 21.07324  ? 164 GLY B N   1 
ATOM   3130 C CA  . GLY B 1 164 ? 35.59148  8.01918   16.42409  1.000 18.92641  ? 164 GLY B CA  1 
ATOM   3131 C C   . GLY B 1 164 ? 36.30235  6.82517   17.02586  1.000 17.38702  ? 164 GLY B C   1 
ATOM   3132 O O   . GLY B 1 164 ? 37.34090  6.94480   17.69190  1.000 22.33353  ? 164 GLY B O   1 
ATOM   3133 N N   . VAL B 1 165 ? 35.72110  5.65626   16.79367  1.000 18.79091  ? 165 VAL B N   1 
ATOM   3134 C CA  . VAL B 1 165 ? 36.38376  4.38881   17.09835  1.000 17.53589  ? 165 VAL B CA  1 
ATOM   3135 C C   . VAL B 1 165 ? 36.06737  3.43719   15.96747  1.000 23.57065  ? 165 VAL B C   1 
ATOM   3136 O O   . VAL B 1 165 ? 34.98373  3.50122   15.37310  1.000 17.56951  ? 165 VAL B O   1 
ATOM   3137 C CB  . VAL B 1 165 ? 35.97255  3.80474   18.46337  1.000 14.82220  ? 165 VAL B CB  1 
ATOM   3138 C CG1 . VAL B 1 165 ? 34.49755  3.51332   18.51525  1.000 19.28706  ? 165 VAL B CG1 1 
ATOM   3139 C CG2 . VAL B 1 165 ? 36.72817  2.53712   18.75828  1.000 20.26663  ? 165 VAL B CG2 1 
ATOM   3140 N N   . ILE B 1 166 ? 37.02701  2.58028   15.64040  1.000 20.56947  ? 166 ILE B N   1 
ATOM   3141 C CA  . ILE B 1 166 ? 36.78588  1.49524   14.70607  1.000 18.52935  ? 166 ILE B CA  1 
ATOM   3142 C C   . ILE B 1 166 ? 37.27095  0.20124   15.32935  1.000 21.38606  ? 166 ILE B C   1 
ATOM   3143 O O   . ILE B 1 166 ? 38.33381  0.17281   15.95955  1.000 21.30389  ? 166 ILE B O   1 
ATOM   3144 C CB  . ILE B 1 166 ? 37.46593  1.74029   13.34613  1.000 20.33989  ? 166 ILE B CB  1 
ATOM   3145 C CG1 . ILE B 1 166 ? 37.30616  0.49131   12.49466  1.000 24.38391  ? 166 ILE B CG1 1 
ATOM   3146 C CG2 . ILE B 1 166 ? 38.98244  2.05987   13.53834  1.000 22.97529  ? 166 ILE B CG2 1 
ATOM   3147 C CD1 . ILE B 1 166 ? 37.76508  0.71742   11.10992  1.000 32.34303  ? 166 ILE B CD1 1 
ATOM   3148 N N   . HIS B 1 167 ? 36.47663  -0.86402  15.17533  1.000 18.08065  ? 167 HIS B N   1 
ATOM   3149 C CA  . HIS B 1 167 ? 36.81748  -2.21276  15.61356  1.000 19.42003  ? 167 HIS B CA  1 
ATOM   3150 C C   . HIS B 1 167 ? 36.85583  -3.09773  14.38612  1.000 22.38791  ? 167 HIS B C   1 
ATOM   3151 O O   . HIS B 1 167 ? 35.89972  -3.10098  13.60799  1.000 20.77508  ? 167 HIS B O   1 
ATOM   3152 C CB  . HIS B 1 167 ? 35.77884  -2.79122  16.59050  1.000 21.28855  ? 167 HIS B CB  1 
ATOM   3153 C CG  . HIS B 1 167 ? 35.56624  -1.95687  17.81588  1.000 24.01073  ? 167 HIS B CG  1 
ATOM   3154 N ND1 . HIS B 1 167 ? 36.55480  -1.75820  18.75221  1.000 23.97952  ? 167 HIS B ND1 1 
ATOM   3155 C CD2 . HIS B 1 167 ? 34.50005  -1.22870  18.23142  1.000 17.82108  ? 167 HIS B CD2 1 
ATOM   3156 C CE1 . HIS B 1 167 ? 36.09159  -0.97541  19.71981  1.000 23.97911  ? 167 HIS B CE1 1 
ATOM   3157 N NE2 . HIS B 1 167 ? 34.85017  -0.62933  19.41827  1.000 19.28314  ? 167 HIS B NE2 1 
ATOM   3158 N N   . LEU B 1 168 ? 37.93519  -3.86166  14.21081  1.000 22.63411  ? 168 LEU B N   1 
ATOM   3159 C CA  . LEU B 1 168 ? 37.97831  -4.79375  13.08534  1.000 18.67078  ? 168 LEU B CA  1 
ATOM   3160 C C   . LEU B 1 168 ? 37.20825  -6.04642  13.46543  1.000 27.53428  ? 168 LEU B C   1 
ATOM   3161 O O   . LEU B 1 168 ? 37.56194  -6.71473  14.44276  1.000 25.32914  ? 168 LEU B O   1 
ATOM   3162 C CB  . LEU B 1 168 ? 39.41229  -5.16357  12.72189  1.000 27.67211  ? 168 LEU B CB  1 
ATOM   3163 C CG  . LEU B 1 168 ? 39.48272  -6.12371  11.51504  1.000 25.08610  ? 168 LEU B CG  1 
ATOM   3164 C CD1 . LEU B 1 168 ? 39.19926  -5.39085  10.23224  1.000 27.00003  ? 168 LEU B CD1 1 
ATOM   3165 C CD2 . LEU B 1 168 ? 40.82199  -6.84261  11.48001  1.000 29.44378  ? 168 LEU B CD2 1 
ATOM   3166 N N   . MET B 1 169 ? 36.16214  -6.37065  12.70612  1.000 22.23406  ? 169 MET B N   1 
ATOM   3167 C CA  . MET B 1 169 ? 35.41097  -7.59016  13.00490  1.000 24.97934  ? 169 MET B CA  1 
ATOM   3168 C C   . MET B 1 169 ? 35.95189  -8.80374  12.26711  1.000 28.50425  ? 169 MET B C   1 
ATOM   3169 O O   . MET B 1 169 ? 35.84278  -9.93667  12.77428  1.000 27.13525  ? 169 MET B O   1 
ATOM   3170 C CB  . MET B 1 169 ? 33.93605  -7.43905  12.63358  1.000 21.48849  ? 169 MET B CB  1 
ATOM   3171 C CG  . MET B 1 169 ? 33.14816  -6.45142  13.49420  1.000 26.22441  ? 169 MET B CG  1 
ATOM   3172 S SD  . MET B 1 169 ? 33.09619  -6.98645  15.22910  1.000 37.21465  ? 169 MET B SD  1 
ATOM   3173 C CE  . MET B 1 169 ? 34.17225  -5.76468  15.83425  1.000 28.39305  ? 169 MET B CE  1 
ATOM   3174 N N   . GLY B 1 170 ? 36.50620  -8.59274  11.07375  1.000 27.34970  ? 170 GLY B N   1 
ATOM   3175 C CA  . GLY B 1 170 ? 37.07385  -9.68387  10.30137  1.000 26.84696  ? 170 GLY B CA  1 
ATOM   3176 C C   . GLY B 1 170 ? 37.70286  -9.18703  9.02242   1.000 28.46146  ? 170 GLY B C   1 
ATOM   3177 O O   . GLY B 1 170 ? 37.32398  -8.13985  8.50724   1.000 25.12381  ? 170 GLY B O   1 
ATOM   3178 N N   . ARG B 1 171 ? 38.67914  -9.93338  8.51757   1.000 31.78157  ? 171 ARG B N   1 
ATOM   3179 C CA  . ARG B 1 171 ? 39.39400  -9.63504  7.27695   1.000 30.73461  ? 171 ARG B CA  1 
ATOM   3180 C C   . ARG B 1 171 ? 39.57487  -10.97516 6.57266   1.000 33.08774  ? 171 ARG B C   1 
ATOM   3181 O O   . ARG B 1 171 ? 40.09930  -11.90802 7.18778   1.000 30.44823  ? 171 ARG B O   1 
ATOM   3182 C CB  . ARG B 1 171 ? 40.75954  -9.02179  7.59074   1.000 31.66931  ? 171 ARG B CB  1 
ATOM   3183 C CG  . ARG B 1 171 ? 41.05316  -7.68108  7.05905   1.000 35.70996  ? 171 ARG B CG  1 
ATOM   3184 C CD  . ARG B 1 171 ? 42.47533  -7.36705  7.41575   1.000 39.83408  ? 171 ARG B CD  1 
ATOM   3185 N NE  . ARG B 1 171 ? 43.39116  -7.48488  6.28976   1.000 41.74821  ? 171 ARG B NE  1 
ATOM   3186 C CZ  . ARG B 1 171 ? 43.80434  -6.44948  5.57159   1.000 45.39845  ? 171 ARG B CZ  1 
ATOM   3187 N NH1 . ARG B 1 171 ? 43.32411  -5.22928  5.78227   1.000 41.05697  ? 171 ARG B NH1 1 
ATOM   3188 N NH2 . ARG B 1 171 ? 44.73485  -6.63611  4.63479   1.000 40.88808  ? 171 ARG B NH2 1 
ATOM   3189 N N   . PHE B 1 172 ? 39.13919  -11.09914 5.31228   1.000 30.11635  ? 172 PHE B N   1 
ATOM   3190 C CA  . PHE B 1 172 ? 39.12428  -12.39226 4.63388   1.000 32.71746  ? 172 PHE B CA  1 
ATOM   3191 C C   . PHE B 1 172 ? 39.77887  -12.24907 3.26887   1.000 31.62281  ? 172 PHE B C   1 
ATOM   3192 O O   . PHE B 1 172 ? 39.35333  -11.40495 2.46973   1.000 28.49786  ? 172 PHE B O   1 
ATOM   3193 C CB  . PHE B 1 172 ? 37.69967  -12.91544 4.50025   1.000 29.96335  ? 172 PHE B CB  1 
ATOM   3194 C CG  . PHE B 1 172 ? 36.95196  -12.97627 5.81984   1.000 40.21625  ? 172 PHE B CG  1 
ATOM   3195 C CD1 . PHE B 1 172 ? 37.14969  -14.03490 6.69389   1.000 44.07873  ? 172 PHE B CD1 1 
ATOM   3196 C CD2 . PHE B 1 172 ? 36.06426  -11.94870 6.20156   1.000 32.75995  ? 172 PHE B CD2 1 
ATOM   3197 C CE1 . PHE B 1 172 ? 36.46890  -14.08736 7.93451   1.000 61.14601  ? 172 PHE B CE1 1 
ATOM   3198 C CE2 . PHE B 1 172 ? 35.38606  -11.99115 7.43354   1.000 41.73555  ? 172 PHE B CE2 1 
ATOM   3199 C CZ  . PHE B 1 172 ? 35.58426  -13.06034 8.30053   1.000 42.10681  ? 172 PHE B CZ  1 
ATOM   3200 N N   . ASN B 1 173 ? 40.83369  -13.04995 3.01567   1.000 30.27247  ? 173 ASN B N   1 
ATOM   3201 C CA  . ASN B 1 173 ? 41.51566  -13.06748 1.71999   1.000 27.84548  ? 173 ASN B CA  1 
ATOM   3202 C C   . ASN B 1 173 ? 42.00414  -11.68003 1.30593   1.000 38.52100  ? 173 ASN B C   1 
ATOM   3203 O O   . ASN B 1 173 ? 42.02926  -11.36310 0.11663   1.000 36.42678  ? 173 ASN B O   1 
ATOM   3204 C CB  . ASN B 1 173 ? 40.58726  -13.64246 0.62997   1.000 36.43435  ? 173 ASN B CB  1 
ATOM   3205 C CG  . ASN B 1 173 ? 41.31013  -13.90887 -0.69699  1.000 40.10562  ? 173 ASN B CG  1 
ATOM   3206 O OD1 . ASN B 1 173 ? 42.47397  -14.29617 -0.70978  1.000 34.14270  ? 173 ASN B OD1 1 
ATOM   3207 N ND2 . ASN B 1 173 ? 40.63378  -13.63671 -1.81326  1.000 37.14025  ? 173 ASN B ND2 1 
ATOM   3208 N N   . ALA B 1 174 ? 42.40019  -10.82612 2.25687   1.000 35.94124  ? 174 ALA B N   1 
ATOM   3209 C CA  . ALA B 1 174 ? 42.56261  -9.39669  1.99224   1.000 35.60768  ? 174 ALA B CA  1 
ATOM   3210 C C   . ALA B 1 174 ? 44.01651  -8.93943  2.10135   1.000 39.40900  ? 174 ALA B C   1 
ATOM   3211 O O   . ALA B 1 174 ? 44.67265  -9.15965  3.12318   1.000 39.84645  ? 174 ALA B O   1 
ATOM   3212 C CB  . ALA B 1 174 ? 41.69684  -8.56193  2.95084   1.000 34.11995  ? 174 ALA B CB  1 
ATOM   3213 N N   . ALA B 1 175 ? 44.49921  -8.25582  1.06881   1.000 27.60453  ? 175 ALA B N   1 
ATOM   3214 C CA  . ALA B 1 175 ? 45.74744  -7.51727  1.15961   1.000 39.77045  ? 175 ALA B CA  1 
ATOM   3215 C C   . ALA B 1 175 ? 45.45486  -6.02562  1.07251   1.000 38.34517  ? 175 ALA B C   1 
ATOM   3216 O O   . ALA B 1 175 ? 44.41742  -5.59126  0.55239   1.000 39.39844  ? 175 ALA B O   1 
ATOM   3217 C CB  . ALA B 1 175 ? 46.73393  -7.93745  0.05822   1.000 46.55159  ? 175 ALA B CB  1 
ATOM   3218 N N   . GLY B 1 176 ? 46.37465  -5.22869  1.59890   1.000 38.19407  ? 176 GLY B N   1 
ATOM   3219 C CA  . GLY B 1 176 ? 46.12743  -3.80378  1.65316   1.000 33.16158  ? 176 GLY B CA  1 
ATOM   3220 C C   . GLY B 1 176 ? 45.18570  -3.45521  2.79553   1.000 30.90374  ? 176 GLY B C   1 
ATOM   3221 O O   . GLY B 1 176 ? 45.09910  -4.15863  3.79898   1.000 33.79455  ? 176 GLY B O   1 
ATOM   3222 N N   . GLY B 1 177 ? 44.45531  -2.36160  2.62266   1.000 29.47844  ? 177 GLY B N   1 
ATOM   3223 C CA  . GLY B 1 177 ? 43.55308  -1.93133  3.66604   1.000 36.39490  ? 177 GLY B CA  1 
ATOM   3224 C C   . GLY B 1 177 ? 44.21789  -1.26682  4.84536   1.000 34.51741  ? 177 GLY B C   1 
ATOM   3225 O O   . GLY B 1 177 ? 43.66824  -1.30284  5.94847   1.000 36.04053  ? 177 GLY B O   1 
ATOM   3226 N N   . GLU B 1 178 ? 45.37681  -0.64430  4.64542   1.000 30.78669  ? 178 GLU B N   1 
ATOM   3227 C CA  . GLU B 1 178 ? 46.02314  0.08756   5.73175   1.000 35.05313  ? 178 GLU B CA  1 
ATOM   3228 C C   . GLU B 1 178 ? 45.18474  1.28402   6.17136   1.000 29.62096  ? 178 GLU B C   1 
ATOM   3229 O O   . GLU B 1 178 ? 44.61377  2.01422   5.35020   1.000 32.00646  ? 178 GLU B O   1 
ATOM   3230 C CB  . GLU B 1 178 ? 47.41529  0.56074   5.30297   1.000 33.56923  ? 178 GLU B CB  1 
ATOM   3231 C CG  . GLU B 1 178 ? 48.39997  -0.57104  5.14166   1.000 36.91379  ? 178 GLU B CG  1 
ATOM   3232 C CD  . GLU B 1 178 ? 48.51810  -1.07770  3.70296   1.000 36.59486  ? 178 GLU B CD  1 
ATOM   3233 O OE1 . GLU B 1 178 ? 47.56822  -0.89543  2.89295   1.000 34.41169  ? 178 GLU B OE1 1 
ATOM   3234 O OE2 . GLU B 1 178 ? 49.57981  -1.64497  3.38795   1.000 41.62464  ? 178 GLU B OE2 1 
ATOM   3235 N N   . SER B 1 179 ? 45.11919  1.50102   7.48225   1.000 27.63553  ? 179 SER B N   1 
ATOM   3236 C CA  . SER B 1 179 ? 44.51887  2.73083   7.98095   1.000 31.79442  ? 179 SER B CA  1 
ATOM   3237 C C   . SER B 1 179 ? 45.56918  3.83262   7.98790   1.000 34.54337  ? 179 SER B C   1 
ATOM   3238 O O   . SER B 1 179 ? 46.72613  3.60700   8.35139   1.000 31.09099  ? 179 SER B O   1 
ATOM   3239 C CB  . SER B 1 179 ? 43.94653  2.52337   9.38796   1.000 36.13219  ? 179 SER B CB  1 
ATOM   3240 O OG  . SER B 1 179 ? 43.32176  1.24277   9.48523   1.000 37.85104  ? 179 SER B OG  1 
ATOM   3241 N N   . GLN B 1 180 ? 45.16309  5.03189   7.59817   1.000 30.24655  ? 180 GLN B N   1 
ATOM   3242 C CA  . GLN B 1 180 ? 46.09075  6.13746   7.42442   1.000 34.32322  ? 180 GLN B CA  1 
ATOM   3243 C C   . GLN B 1 180 ? 45.65831  7.34270   8.25197   1.000 36.79372  ? 180 GLN B C   1 
ATOM   3244 O O   . GLN B 1 180 ? 44.51277  7.79476   8.15557   1.000 29.76763  ? 180 GLN B O   1 
ATOM   3245 C CB  . GLN B 1 180 ? 46.19502  6.53468   5.95304   1.000 32.81328  ? 180 GLN B CB  1 
ATOM   3246 C CG  . GLN B 1 180 ? 46.74693  5.42626   5.09837   1.000 34.03679  ? 180 GLN B CG  1 
ATOM   3247 C CD  . GLN B 1 180 ? 46.89808  5.85517   3.66279   1.000 41.66021  ? 180 GLN B CD  1 
ATOM   3248 O OE1 . GLN B 1 180 ? 45.96121  6.40558   3.05581   1.000 39.51529  ? 180 GLN B OE1 1 
ATOM   3249 N NE2 . GLN B 1 180 ? 48.09077  5.62970   3.10779   1.000 40.13475  ? 180 GLN B NE2 1 
ATOM   3250 N N   . VAL B 1 181 ? 46.58559  7.86871   9.04215   1.000 34.85354  ? 181 VAL B N   1 
ATOM   3251 C CA  . VAL B 1 181 ? 46.38302  9.10066   9.78928   1.000 36.92425  ? 181 VAL B CA  1 
ATOM   3252 C C   . VAL B 1 181 ? 47.15540  10.21011  9.10127   1.000 43.28107  ? 181 VAL B C   1 
ATOM   3253 O O   . VAL B 1 181 ? 48.37819  10.10839  8.93598   1.000 43.67868  ? 181 VAL B O   1 
ATOM   3254 C CB  . VAL B 1 181 ? 46.84384  8.95610   11.24008  1.000 36.31719  ? 181 VAL B CB  1 
ATOM   3255 C CG1 . VAL B 1 181 ? 46.72946  10.31025  11.93694  1.000 42.40343  ? 181 VAL B CG1 1 
ATOM   3256 C CG2 . VAL B 1 181 ? 46.04447  7.89299   11.93876  1.000 39.40127  ? 181 VAL B CG2 1 
ATOM   3257 N N   . TYR B 1 182 ? 46.44647  11.27885  8.74038   1.000 40.73189  ? 182 TYR B N   1 
ATOM   3258 C CA  . TYR B 1 182 ? 47.01361  12.46824  8.13118   1.000 41.57821  ? 182 TYR B CA  1 
ATOM   3259 C C   . TYR B 1 182 ? 46.95454  13.65895  9.07738   1.000 45.37180  ? 182 TYR B C   1 
ATOM   3260 O O   . TYR B 1 182 ? 46.04701  13.77312  9.91250   1.000 34.08583  ? 182 TYR B O   1 
ATOM   3261 C CB  . TYR B 1 182 ? 46.25765  12.82708  6.84646   1.000 36.93429  ? 182 TYR B CB  1 
ATOM   3262 C CG  . TYR B 1 182 ? 46.49825  11.84969  5.72071   1.000 47.52633  ? 182 TYR B CG  1 
ATOM   3263 C CD1 . TYR B 1 182 ? 45.76094  10.67086  5.62771   1.000 35.25184  ? 182 TYR B CD1 1 
ATOM   3264 C CD2 . TYR B 1 182 ? 47.47629  12.10458  4.74383   1.000 49.29678  ? 182 TYR B CD2 1 
ATOM   3265 C CE1 . TYR B 1 182 ? 45.97927  9.77804   4.59865   1.000 44.23011  ? 182 TYR B CE1 1 
ATOM   3266 C CE2 . TYR B 1 182 ? 47.70372  11.20989  3.70948   1.000 46.19998  ? 182 TYR B CE2 1 
ATOM   3267 C CZ  . TYR B 1 182 ? 46.95476  10.04754  3.64678   1.000 50.98108  ? 182 TYR B CZ  1 
ATOM   3268 O OH  . TYR B 1 182 ? 47.16361  9.14826   2.63689   1.000 52.93981  ? 182 TYR B OH  1 
ATOM   3269 N N   . SER B 1 183 ? 47.91360  14.57257  8.90220   1.000 47.20252  ? 183 SER B N   1 
ATOM   3270 C CA  . SER B 1 183 ? 47.81181  15.90134  9.48287   1.000 42.89289  ? 183 SER B CA  1 
ATOM   3271 C C   . SER B 1 183 ? 46.70596  16.69357  8.79087   1.000 41.90329  ? 183 SER B C   1 
ATOM   3272 O O   . SER B 1 183 ? 46.23052  16.34509  7.70252   1.000 40.77381  ? 183 SER B O   1 
ATOM   3273 C CB  . SER B 1 183 ? 49.13781  16.64941  9.34801   1.000 55.39724  ? 183 SER B CB  1 
ATOM   3274 O OG  . SER B 1 183 ? 49.41810  16.89758  7.97772   1.000 51.74347  ? 183 SER B OG  1 
ATOM   3275 N N   . LEU B 1 184 ? 46.29213  17.78345  9.43394   1.000 44.43736  ? 184 LEU B N   1 
ATOM   3276 C CA  . LEU B 1 184 ? 45.26289  18.61700  8.81908   1.000 49.81194  ? 184 LEU B CA  1 
ATOM   3277 C C   . LEU B 1 184 ? 45.74146  19.20697  7.49882   1.000 48.66894  ? 184 LEU B C   1 
ATOM   3278 O O   . LEU B 1 184 ? 44.92827  19.50218  6.61148   1.000 50.21725  ? 184 LEU B O   1 
ATOM   3279 C CB  . LEU B 1 184 ? 44.83393  19.73162  9.77322   1.000 42.90020  ? 184 LEU B CB  1 
ATOM   3280 C CG  . LEU B 1 184 ? 44.02895  19.38765  11.03352  1.000 47.87203  ? 184 LEU B CG  1 
ATOM   3281 C CD1 . LEU B 1 184 ? 43.39038  20.64684  11.58721  1.000 35.97667  ? 184 LEU B CD1 1 
ATOM   3282 C CD2 . LEU B 1 184 ? 42.96244  18.33471  10.75263  1.000 42.53985  ? 184 LEU B CD2 1 
ATOM   3283 N N   . GLU B 1 185 ? 47.05035  19.37868  7.35203   1.000 57.44420  ? 185 GLU B N   1 
ATOM   3284 C CA  . GLU B 1 185 ? 47.71477  19.86690  6.14883   1.000 58.69909  ? 185 GLU B CA  1 
ATOM   3285 C C   . GLU B 1 185 ? 47.78770  18.82516  5.08323   1.000 60.68959  ? 185 GLU B C   1 
ATOM   3286 O O   . GLU B 1 185 ? 48.43651  19.03182  4.05912   1.000 62.57123  ? 185 GLU B O   1 
ATOM   3287 C CB  . GLU B 1 185 ? 49.11969  20.36044  6.50295   1.000 55.18311  ? 185 GLU B CB  1 
ATOM   3288 C CG  . GLU B 1 185 ? 49.14168  21.47541  7.53296   1.000 67.69162  ? 185 GLU B CG  1 
ATOM   3289 C CD  . GLU B 1 185 ? 49.17927  20.97417  8.98546   1.000 72.55029  ? 185 GLU B CD  1 
ATOM   3290 O OE1 . GLU B 1 185 ? 48.81525  19.80452  9.25390   1.000 63.42924  ? 185 GLU B OE1 1 
ATOM   3291 O OE2 . GLU B 1 185 ? 49.58027  21.76453  9.86645   1.000 82.41837  ? 185 GLU B OE2 1 
ATOM   3292 N N   . ARG B 1 186 ? 47.13762  17.69315  5.34645   1.000 61.46222  ? 186 ARG B N   1 
ATOM   3293 C CA  . ARG B 1 186 ? 46.94278  16.62615  4.37438   1.000 52.75918  ? 186 ARG B CA  1 
ATOM   3294 C C   . ARG B 1 186 ? 48.22640  15.85163  4.09493   1.000 49.11664  ? 186 ARG B C   1 
ATOM   3295 O O   . ARG B 1 186 ? 48.38961  15.29171  3.01595   1.000 49.08665  ? 186 ARG B O   1 
ATOM   3296 C CB  . ARG B 1 186 ? 46.31812  17.15847  3.08090   1.000 53.67414  ? 186 ARG B CB  1 
ATOM   3297 C CG  . ARG B 1 186 ? 44.88228  17.64795  3.29275   1.000 52.16301  ? 186 ARG B CG  1 
ATOM   3298 C CD  . ARG B 1 186 ? 44.24368  18.24912  2.04678   1.000 48.51750  ? 186 ARG B CD  1 
ATOM   3299 N NE  . ARG B 1 186 ? 44.21916  17.32369  0.92133   1.000 63.37455  ? 186 ARG B NE  1 
ATOM   3300 C CZ  . ARG B 1 186 ? 43.28114  16.40676  0.71703   1.000 67.78564  ? 186 ARG B CZ  1 
ATOM   3301 N NH1 . ARG B 1 186 ? 42.28831  16.22543  1.57482   1.000 61.97673  ? 186 ARG B NH1 1 
ATOM   3302 N NH2 . ARG B 1 186 ? 43.34330  15.64619  -0.37384  1.000 67.46005  ? 186 ARG B NH2 1 
ATOM   3303 N N   . GLU B 1 187 ? 49.10046  15.73769  5.09293   1.000 49.87764  ? 187 GLU B N   1 
ATOM   3304 C CA  . GLU B 1 187 ? 50.33678  14.97527  4.98848   1.000 45.24276  ? 187 GLU B CA  1 
ATOM   3305 C C   . GLU B 1 187 ? 50.27501  13.71453  5.84234   1.000 51.40098  ? 187 GLU B C   1 
ATOM   3306 O O   . GLU B 1 187 ? 49.80564  13.74672  6.98215   1.000 49.61116  ? 187 GLU B O   1 
ATOM   3307 C CB  . GLU B 1 187 ? 51.53405  15.83332  5.41254   1.000 55.92753  ? 187 GLU B CB  1 
ATOM   3308 C CG  . GLU B 1 187 ? 51.70611  17.11022  4.57360   1.000 59.16598  ? 187 GLU B CG  1 
ATOM   3309 C CD  . GLU B 1 187 ? 52.17063  16.83728  3.13314   1.000 74.33024  ? 187 GLU B CD  1 
ATOM   3310 O OE1 . GLU B 1 187 ? 52.88111  15.83073  2.90922   1.000 75.92486  ? 187 GLU B OE1 1 
ATOM   3311 O OE2 . GLU B 1 187 ? 51.83228  17.63202  2.21997   1.000 78.37502  ? 187 GLU B OE2 1 
ATOM   3312 N N   . LEU B 1 188 ? 50.78566  12.61234  5.29831   1.000 49.52247  ? 188 LEU B N   1 
ATOM   3313 C CA  . LEU B 1 188 ? 50.65343  11.31021  5.93952   1.000 49.30154  ? 188 LEU B CA  1 
ATOM   3314 C C   . LEU B 1 188 ? 51.59937  11.21850  7.12714   1.000 53.20437  ? 188 LEU B C   1 
ATOM   3315 O O   . LEU B 1 188 ? 52.81551  11.33269  6.95930   1.000 51.27942  ? 188 LEU B O   1 
ATOM   3316 C CB  . LEU B 1 188 ? 50.94138  10.18989  4.93872   1.000 43.03281  ? 188 LEU B CB  1 
ATOM   3317 C CG  . LEU B 1 188 ? 50.74238  8.78156   5.50439   1.000 54.16790  ? 188 LEU B CG  1 
ATOM   3318 C CD1 . LEU B 1 188 ? 49.27899  8.36555   5.44321   1.000 41.96378  ? 188 LEU B CD1 1 
ATOM   3319 C CD2 . LEU B 1 188 ? 51.60853  7.75981   4.79000   1.000 52.53319  ? 188 LEU B CD2 1 
ATOM   3320 N N   . VAL B 1 189 ? 51.05198  11.00275  8.32729   1.000 47.22964  ? 189 VAL B N   1 
ATOM   3321 C CA  . VAL B 1 189 ? 51.86622  10.91149  9.52738   1.000 47.09593  ? 189 VAL B CA  1 
ATOM   3322 C C   . VAL B 1 189 ? 52.00269  9.48352   10.03840  1.000 48.65037  ? 189 VAL B C   1 
ATOM   3323 O O   . VAL B 1 189 ? 52.99906  9.17146   10.70331  1.000 52.29039  ? 189 VAL B O   1 
ATOM   3324 C CB  . VAL B 1 189 ? 51.33335  11.83575  10.64475  1.000 47.92844  ? 189 VAL B CB  1 
ATOM   3325 C CG1 . VAL B 1 189 ? 50.52253  12.97893  10.06006  1.000 50.72470  ? 189 VAL B CG1 1 
ATOM   3326 C CG2 . VAL B 1 189 ? 50.52933  11.06111  11.65282  1.000 49.67436  ? 189 VAL B CG2 1 
ATOM   3327 N N   . ALA B 1 190 ? 51.04397  8.60586   9.76441   1.000 41.20753  ? 190 ALA B N   1 
ATOM   3328 C CA  . ALA B 1 190 ? 51.17750  7.24680   10.26500  1.000 42.15567  ? 190 ALA B CA  1 
ATOM   3329 C C   . ALA B 1 190 ? 50.31468  6.31568   9.43455   1.000 39.27689  ? 190 ALA B C   1 
ATOM   3330 O O   . ALA B 1 190 ? 49.32781  6.72037   8.81355   1.000 40.06370  ? 190 ALA B O   1 
ATOM   3331 C CB  . ALA B 1 190 ? 50.79575  7.13840   11.74231  1.000 44.71920  ? 190 ALA B CB  1 
ATOM   3332 N N   . GLU B 1 191 ? 50.70221  5.05640   9.45180   1.000 41.70418  ? 191 GLU B N   1 
ATOM   3333 C CA  . GLU B 1 191 ? 50.00456  4.03182   8.70576   1.000 40.71694  ? 191 GLU B CA  1 
ATOM   3334 C C   . GLU B 1 191 ? 50.09414  2.76882   9.53945   1.000 45.42801  ? 191 GLU B C   1 
ATOM   3335 O O   . GLU B 1 191 ? 51.19042  2.37792   9.94856   1.000 42.36156  ? 191 GLU B O   1 
ATOM   3336 C CB  . GLU B 1 191 ? 50.63861  3.83921   7.32787   1.000 44.50352  ? 191 GLU B CB  1 
ATOM   3337 C CG  . GLU B 1 191 ? 49.65787  3.43046   6.27271   1.000 41.08530  ? 191 GLU B CG  1 
ATOM   3338 C CD  . GLU B 1 191 ? 50.27641  3.25067   4.90177   1.000 36.36798  ? 191 GLU B CD  1 
ATOM   3339 O OE1 . GLU B 1 191 ? 51.10629  2.32350   4.75257   1.000 44.09708  ? 191 GLU B OE1 1 
ATOM   3340 O OE2 . GLU B 1 191 ? 49.90858  4.02890   3.98493   1.000 35.41579  ? 191 GLU B OE2 1 
ATOM   3341 N N   . PHE B 1 192 ? 48.94799  2.16538   9.83061   1.000 34.88410  ? 192 PHE B N   1 
ATOM   3342 C CA  . PHE B 1 192 ? 48.89175  0.89447   10.52507  1.000 35.72929  ? 192 PHE B CA  1 
ATOM   3343 C C   . PHE B 1 192 ? 47.88532  0.02555   9.80327   1.000 39.18205  ? 192 PHE B C   1 
ATOM   3344 O O   . PHE B 1 192 ? 47.09091  0.50492   8.99465   1.000 38.65663  ? 192 PHE B O   1 
ATOM   3345 C CB  . PHE B 1 192 ? 48.50649  1.05407   12.00691  1.000 38.42851  ? 192 PHE B CB  1 
ATOM   3346 C CG  . PHE B 1 192 ? 47.59040  2.19920   12.26842  1.000 43.57850  ? 192 PHE B CG  1 
ATOM   3347 C CD1 . PHE B 1 192 ? 48.09194  3.49447   12.38829  1.000 45.26116  ? 192 PHE B CD1 1 
ATOM   3348 C CD2 . PHE B 1 192 ? 46.22458  1.99601   12.38539  1.000 46.97724  ? 192 PHE B CD2 1 
ATOM   3349 C CE1 . PHE B 1 192 ? 47.24555  4.56302   12.61166  1.000 50.15653  ? 192 PHE B CE1 1 
ATOM   3350 C CE2 . PHE B 1 192 ? 45.36408  3.06381   12.62348  1.000 49.05595  ? 192 PHE B CE2 1 
ATOM   3351 C CZ  . PHE B 1 192 ? 45.87883  4.34763   12.73130  1.000 53.80714  ? 192 PHE B CZ  1 
ATOM   3352 N N   . CYS B 1 193 ? 47.92280  -1.26449  10.11013  1.000 38.39882  ? 193 CYS B N   1 
ATOM   3353 C CA  . CYS B 1 193 ? 47.06826  -2.24628  9.46296   1.000 38.92248  ? 193 CYS B CA  1 
ATOM   3354 C C   . CYS B 1 193 ? 46.39205  -3.05560  10.56010  1.000 39.13013  ? 193 CYS B C   1 
ATOM   3355 O O   . CYS B 1 193 ? 47.05989  -3.79584  11.28999  1.000 43.14090  ? 193 CYS B O   1 
ATOM   3356 C CB  . CYS B 1 193 ? 47.87617  -3.14916  8.51962   1.000 45.48492  ? 193 CYS B CB  1 
ATOM   3357 S SG  . CYS B 1 193 ? 46.84030  -4.10655  7.33008   1.000 57.68079  ? 193 CYS B SG  1 
ATOM   3358 N N   . LEU B 1 194 ? 45.07667  -2.90476  10.68184  1.000 35.49714  ? 194 LEU B N   1 
ATOM   3359 C CA  . LEU B 1 194 ? 44.30203  -3.71367  11.60973  1.000 36.68830  ? 194 LEU B CA  1 
ATOM   3360 C C   . LEU B 1 194 ? 44.06779  -5.07272  10.96052  1.000 37.61172  ? 194 LEU B C   1 
ATOM   3361 O O   . LEU B 1 194 ? 43.52543  -5.15432  9.85105   1.000 34.23638  ? 194 LEU B O   1 
ATOM   3362 C CB  . LEU B 1 194 ? 42.96938  -3.04157  11.94732  1.000 35.35424  ? 194 LEU B CB  1 
ATOM   3363 C CG  . LEU B 1 194 ? 42.95536  -1.59483  12.43358  1.000 35.48184  ? 194 LEU B CG  1 
ATOM   3364 C CD1 . LEU B 1 194 ? 41.52793  -1.20662  12.75786  1.000 36.39912  ? 194 LEU B CD1 1 
ATOM   3365 C CD2 . LEU B 1 194 ? 43.82494  -1.41676  13.63888  1.000 35.88631  ? 194 LEU B CD2 1 
ATOM   3366 N N   . THR B 1 195 ? 44.48962  -6.13622  11.62388  1.000 31.95879  ? 195 THR B N   1 
ATOM   3367 C CA  . THR B 1 195 ? 44.39691  -7.44704  11.00880  1.000 35.63030  ? 195 THR B CA  1 
ATOM   3368 C C   . THR B 1 195 ? 43.70984  -8.47667  11.87826  1.000 34.53428  ? 195 THR B C   1 
ATOM   3369 O O   . THR B 1 195 ? 43.18199  -9.44675  11.33101  1.000 37.58714  ? 195 THR B O   1 
ATOM   3370 C CB  . THR B 1 195 ? 45.79716  -7.97465  10.63401  1.000 40.97229  ? 195 THR B CB  1 
ATOM   3371 O OG1 . THR B 1 195 ? 46.68241  -7.82694  11.74852  1.000 40.71569  ? 195 THR B OG1 1 
ATOM   3372 C CG2 . THR B 1 195 ? 46.37674  -7.20718  9.43851   1.000 44.74272  ? 195 THR B CG2 1 
ATOM   3373 N N   . GLU B 1 196 ? 43.67468  -8.30442  13.20292  1.000 34.87603  ? 196 GLU B N   1 
ATOM   3374 C CA  . GLU B 1 196 ? 43.04665  -9.27480  14.09059  1.000 34.27174  ? 196 GLU B CA  1 
ATOM   3375 C C   . GLU B 1 196 ? 41.67209  -8.79147  14.54519  1.000 31.13792  ? 196 GLU B C   1 
ATOM   3376 O O   . GLU B 1 196 ? 41.43220  -7.59416  14.73435  1.000 30.43125  ? 196 GLU B O   1 
ATOM   3377 C CB  . GLU B 1 196 ? 43.92218  -9.53824  15.31990  1.000 38.51115  ? 196 GLU B CB  1 
ATOM   3378 C CG  . GLU B 1 196 ? 45.38972  -9.82365  15.00202  1.000 42.97795  ? 196 GLU B CG  1 
ATOM   3379 C CD  . GLU B 1 196 ? 45.55700  -11.05339 14.14100  1.000 49.48937  ? 196 GLU B CD  1 
ATOM   3380 O OE1 . GLU B 1 196 ? 45.03937  -12.12747 14.52861  1.000 50.83420  ? 196 GLU B OE1 1 
ATOM   3381 O OE2 . GLU B 1 196 ? 46.18858  -10.93212 13.06525  1.000 51.93313  ? 196 GLU B OE2 1 
ATOM   3382 N N   . GLN B 1 197 ? 40.78566  -9.74494  14.76555  1.000 25.81860  ? 197 GLN B N   1 
ATOM   3383 C CA  . GLN B 1 197 ? 39.45480  -9.41244  15.22496  1.000 28.77508  ? 197 GLN B CA  1 
ATOM   3384 C C   . GLN B 1 197 ? 39.53702  -8.67154  16.55722  1.000 30.51233  ? 197 GLN B C   1 
ATOM   3385 O O   . GLN B 1 197 ? 40.25162  -9.08870  17.47289  1.000 26.50411  ? 197 GLN B O   1 
ATOM   3386 C CB  . GLN B 1 197 ? 38.63957  -10.68313 15.33654  1.000 24.52980  ? 197 GLN B CB  1 
ATOM   3387 C CG  . GLN B 1 197 ? 37.22388  -10.46376 15.71077  1.000 28.19401  ? 197 GLN B CG  1 
ATOM   3388 C CD  . GLN B 1 197 ? 36.51083  -11.76644 15.87243  1.000 32.41348  ? 197 GLN B CD  1 
ATOM   3389 O OE1 . GLN B 1 197 ? 36.79672  -12.52928 16.79057  1.000 36.71000  ? 197 GLN B OE1 1 
ATOM   3390 N NE2 . GLN B 1 197 ? 35.60732  -12.05927 14.95431  1.000 30.87587  ? 197 GLN B NE2 1 
ATOM   3391 N N   . MET B 1 198 ? 38.86295  -7.52389  16.62666  1.000 30.09769  ? 198 MET B N   1 
ATOM   3392 C CA  . MET B 1 198 ? 38.81233  -6.58986  17.77658  1.000 28.16816  ? 198 MET B CA  1 
ATOM   3393 C C   . MET B 1 198 ? 40.06624  -5.73043  17.89194  1.000 28.05529  ? 198 MET B C   1 
ATOM   3394 O O   . MET B 1 198 ? 40.15020  -4.96432  18.83106  1.000 32.02647  ? 198 MET B O   1 
ATOM   3395 C CB  . MET B 1 198 ? 38.56082  -7.28729  19.12523  1.000 28.17789  ? 198 MET B CB  1 
ATOM   3396 C CG  . MET B 1 198 ? 37.15002  -7.84263  19.30727  1.000 34.96057  ? 198 MET B CG  1 
ATOM   3397 S SD  . MET B 1 198 ? 35.80333  -6.66132  18.94362  1.000 39.29554  ? 198 MET B SD  1 
ATOM   3398 C CE  . MET B 1 198 ? 36.26892  -5.28318  19.98674  1.000 28.61965  ? 198 MET B CE  1 
ATOM   3399 N N   . ASP B 1 199 ? 41.01742  -5.79504  16.95249  1.000 27.82813  ? 199 ASP B N   1 
ATOM   3400 C CA  . ASP B 1 199 ? 41.96272  -4.69784  16.78664  1.000 25.91492  ? 199 ASP B CA  1 
ATOM   3401 C C   . ASP B 1 199 ? 41.16582  -3.40618  16.64176  1.000 31.55447  ? 199 ASP B C   1 
ATOM   3402 O O   . ASP B 1 199 ? 40.20502  -3.36113  15.88098  1.000 23.37180  ? 199 ASP B O   1 
ATOM   3403 C CB  . ASP B 1 199 ? 42.81910  -4.85803  15.52173  1.000 24.58076  ? 199 ASP B CB  1 
ATOM   3404 C CG  . ASP B 1 199 ? 43.98147  -5.87193  15.66274  1.000 33.75778  ? 199 ASP B CG  1 
ATOM   3405 O OD1 . ASP B 1 199 ? 44.25158  -6.39110  16.75280  1.000 29.54920  ? 199 ASP B OD1 1 
ATOM   3406 O OD2 . ASP B 1 199 ? 44.61246  -6.16654  14.62171  1.000 34.83534  ? 199 ASP B OD2 1 
ATOM   3407 N N   . THR B 1 200 ? 41.60852  -2.34147  17.31242  1.000 21.72050  ? 200 THR B N   1 
ATOM   3408 C CA  . THR B 1 200 ? 40.79217  -1.15897  17.55669  1.000 22.82805  ? 200 THR B CA  1 
ATOM   3409 C C   . THR B 1 200 ? 41.65082  0.06980   17.36096  1.000 25.22283  ? 200 THR B C   1 
ATOM   3410 O O   . THR B 1 200 ? 42.83921  0.05337   17.70167  1.000 27.74878  ? 200 THR B O   1 
ATOM   3411 C CB  . THR B 1 200 ? 40.22212  -1.16500  19.00042  1.000 25.76207  ? 200 THR B CB  1 
ATOM   3412 O OG1 . THR B 1 200 ? 39.25697  -2.20604  19.12292  1.000 26.12458  ? 200 THR B OG1 1 
ATOM   3413 C CG2 . THR B 1 200 ? 39.57689  0.14746   19.34166  1.000 23.48565  ? 200 THR B CG2 1 
ATOM   3414 N N   . MET B 1 201 ? 41.07177  1.11827   16.78336  1.000 24.21651  ? 201 MET B N   1 
ATOM   3415 C CA  . MET B 1 201 ? 41.69711  2.43511   16.78054  1.000 24.76147  ? 201 MET B CA  1 
ATOM   3416 C C   . MET B 1 201 ? 40.69089  3.49581   17.22545  1.000 28.06881  ? 201 MET B C   1 
ATOM   3417 O O   . MET B 1 201 ? 39.53419  3.46917   16.80532  1.000 25.50022  ? 201 MET B O   1 
ATOM   3418 C CB  . MET B 1 201 ? 42.26493  2.75403   15.39110  1.000 28.40777  ? 201 MET B CB  1 
ATOM   3419 C CG  . MET B 1 201 ? 43.25469  3.87262   15.39211  1.000 41.56080  ? 201 MET B CG  1 
ATOM   3420 S SD  . MET B 1 201 ? 42.50287  5.32117   14.64390  1.000 75.50601  ? 201 MET B SD  1 
ATOM   3421 C CE  . MET B 1 201 ? 42.58004  4.86741   12.91147  1.000 56.68195  ? 201 MET B CE  1 
ATOM   3422 N N   . PHE B 1 202 ? 41.11613  4.40576   18.10809  1.000 25.85834  ? 202 PHE B N   1 
ATOM   3423 C CA  . PHE B 1 202 ? 40.31593  5.56462   18.51861  1.000 27.33559  ? 202 PHE B CA  1 
ATOM   3424 C C   . PHE B 1 202 ? 40.91570  6.81649   17.88540  1.000 27.81614  ? 202 PHE B C   1 
ATOM   3425 O O   . PHE B 1 202 ? 42.13047  6.86839   17.68488  1.000 30.50406  ? 202 PHE B O   1 
ATOM   3426 C CB  . PHE B 1 202 ? 40.30473  5.76186   20.05473  1.000 24.97287  ? 202 PHE B CB  1 
ATOM   3427 C CG  . PHE B 1 202 ? 40.09930  4.51143   20.85151  1.000 26.81195  ? 202 PHE B CG  1 
ATOM   3428 C CD1 . PHE B 1 202 ? 38.82219  4.07707   21.15951  1.000 24.32539  ? 202 PHE B CD1 1 
ATOM   3429 C CD2 . PHE B 1 202 ? 41.17413  3.81148   21.35685  1.000 25.16317  ? 202 PHE B CD2 1 
ATOM   3430 C CE1 . PHE B 1 202 ? 38.62482  2.91070   21.88528  1.000 26.74751  ? 202 PHE B CE1 1 
ATOM   3431 C CE2 . PHE B 1 202 ? 41.00274  2.67419   22.10470  1.000 26.23496  ? 202 PHE B CE2 1 
ATOM   3432 C CZ  . PHE B 1 202 ? 39.71734  2.20292   22.37147  1.000 29.63612  ? 202 PHE B CZ  1 
ATOM   3433 N N   . TRP B 1 203 ? 40.09369  7.83570   17.57914  1.000 22.67533  ? 203 TRP B N   1 
ATOM   3434 C CA  . TRP B 1 203 ? 40.67580  9.04984   16.99170  1.000 28.47188  ? 203 TRP B CA  1 
ATOM   3435 C C   . TRP B 1 203 ? 39.86350  10.29865  17.31029  1.000 30.87394  ? 203 TRP B C   1 
ATOM   3436 O O   . TRP B 1 203 ? 38.66597  10.23487  17.59518  1.000 26.33111  ? 203 TRP B O   1 
ATOM   3437 C CB  . TRP B 1 203 ? 40.86978  8.92044   15.45626  1.000 28.34545  ? 203 TRP B CB  1 
ATOM   3438 C CG  . TRP B 1 203 ? 39.68557  9.15592   14.59108  1.000 29.75092  ? 203 TRP B CG  1 
ATOM   3439 C CD1 . TRP B 1 203 ? 39.34379  10.32035  14.00198  1.000 23.08028  ? 203 TRP B CD1 1 
ATOM   3440 C CD2 . TRP B 1 203 ? 38.71015  8.17495   14.15534  1.000 25.42681  ? 203 TRP B CD2 1 
ATOM   3441 N NE1 . TRP B 1 203 ? 38.21421  10.16005  13.23138  1.000 27.17741  ? 203 TRP B NE1 1 
ATOM   3442 C CE2 . TRP B 1 203 ? 37.79380  8.84956   13.32420  1.000 26.48766  ? 203 TRP B CE2 1 
ATOM   3443 C CE3 . TRP B 1 203 ? 38.51784  6.80980   14.41778  1.000 27.17510  ? 203 TRP B CE3 1 
ATOM   3444 C CZ2 . TRP B 1 203 ? 36.69573  8.21330   12.74035  1.000 17.63182  ? 203 TRP B CZ2 1 
ATOM   3445 C CZ3 . TRP B 1 203 ? 37.41945  6.15736   13.81280  1.000 19.33932  ? 203 TRP B CZ3 1 
ATOM   3446 C CH2 . TRP B 1 203 ? 36.52455  6.87808   12.99068  1.000 19.82472  ? 203 TRP B CH2 1 
ATOM   3447 N N   . SER B 1 204 ? 40.55199  11.45557  17.27879  1.000 28.38478  ? 204 SER B N   1 
ATOM   3448 C CA  . SER B 1 204 ? 39.94253  12.77445  17.47763  1.000 27.49413  ? 204 SER B CA  1 
ATOM   3449 C C   . SER B 1 204 ? 39.64694  13.39013  16.12556  1.000 32.29683  ? 204 SER B C   1 
ATOM   3450 O O   . SER B 1 204 ? 40.55307  13.90190  15.44840  1.000 34.13376  ? 204 SER B O   1 
ATOM   3451 C CB  . SER B 1 204 ? 40.84856  13.71731  18.27040  1.000 26.69166  ? 204 SER B CB  1 
ATOM   3452 O OG  . SER B 1 204 ? 41.13709  13.19343  19.55017  1.000 34.30876  ? 204 SER B OG  1 
ATOM   3453 N N   . ASP B 1 205 ? 38.37518  13.38597  15.75438  1.000 26.21629  ? 205 ASP B N   1 
ATOM   3454 C CA  . ASP B 1 205 ? 38.02100  13.63648  14.36769  1.000 27.56996  ? 205 ASP B CA  1 
ATOM   3455 C C   . ASP B 1 205 ? 38.26729  15.06183  13.93190  1.000 32.53694  ? 205 ASP B C   1 
ATOM   3456 O O   . ASP B 1 205 ? 38.22573  15.32583  12.72424  1.000 28.94260  ? 205 ASP B O   1 
ATOM   3457 C CB  . ASP B 1 205 ? 36.55945  13.29262  14.12224  1.000 22.55619  ? 205 ASP B CB  1 
ATOM   3458 C CG  . ASP B 1 205 ? 36.24600  13.19211  12.67001  1.000 28.03993  ? 205 ASP B CG  1 
ATOM   3459 O OD1 . ASP B 1 205 ? 36.86044  12.31254  12.00587  1.000 24.17498  ? 205 ASP B OD1 1 
ATOM   3460 O OD2 . ASP B 1 205 ? 35.39414  13.99689  12.19491  1.000 30.43927  ? 205 ASP B OD2 1 
ATOM   3461 N N   . GLY B 1 206 ? 38.47390  15.98310  14.86535  1.000 35.05221  ? 206 GLY B N   1 
ATOM   3462 C CA  . GLY B 1 206 ? 38.78702  17.35691  14.49936  1.000 36.63347  ? 206 GLY B CA  1 
ATOM   3463 C C   . GLY B 1 206 ? 40.27985  17.62755  14.56719  1.000 33.82199  ? 206 GLY B C   1 
ATOM   3464 O O   . GLY B 1 206 ? 40.75074  18.69291  14.16737  1.000 43.90780  ? 206 GLY B O   1 
ATOM   3465 N N   . GLN B 1 207 ? 41.03344  16.66477  15.07947  1.000 33.29783  ? 207 GLN B N   1 
ATOM   3466 C CA  . GLN B 1 207 ? 42.47501  16.79943  15.21314  1.000 33.89650  ? 207 GLN B CA  1 
ATOM   3467 C C   . GLN B 1 207 ? 43.23430  16.27534  13.99468  1.000 42.91311  ? 207 GLN B C   1 
ATOM   3468 O O   . GLN B 1 207 ? 44.28624  16.82521  13.63893  1.000 35.19781  ? 207 GLN B O   1 
ATOM   3469 C CB  . GLN B 1 207 ? 42.92892  16.06115  16.47195  1.000 41.55715  ? 207 GLN B CB  1 
ATOM   3470 C CG  . GLN B 1 207 ? 44.39589  16.20101  16.80302  1.000 48.06800  ? 207 GLN B CG  1 
ATOM   3471 C CD  . GLN B 1 207 ? 44.63029  16.36942  18.28273  1.000 54.53894  ? 207 GLN B CD  1 
ATOM   3472 O OE1 . GLN B 1 207 ? 43.75021  16.08300  19.10015  1.000 54.90214  ? 207 GLN B OE1 1 
ATOM   3473 N NE2 . GLN B 1 207 ? 45.81226  16.85976  18.63998  1.000 63.02601  ? 207 GLN B NE2 1 
ATOM   3474 N N   . ILE B 1 208 ? 42.74408  15.21313  13.34610  1.000 38.45448  ? 208 ILE B N   1 
ATOM   3475 C CA  . ILE B 1 208 ? 43.44539  14.59540  12.23082  1.000 34.98680  ? 208 ILE B CA  1 
ATOM   3476 C C   . ILE B 1 208 ? 42.50042  14.44646  11.05498  1.000 34.04330  ? 208 ILE B C   1 
ATOM   3477 O O   . ILE B 1 208 ? 41.30879  14.74914  11.12527  1.000 37.05776  ? 208 ILE B O   1 
ATOM   3478 C CB  . ILE B 1 208 ? 44.04090  13.20885  12.57113  1.000 36.44642  ? 208 ILE B CB  1 
ATOM   3479 C CG1 . ILE B 1 208 ? 42.91827  12.18696  12.80439  1.000 29.45534  ? 208 ILE B CG1 1 
ATOM   3480 C CG2 . ILE B 1 208 ? 44.96077  13.26892  13.75254  1.000 35.43856  ? 208 ILE B CG2 1 
ATOM   3481 C CD1 . ILE B 1 208 ? 43.45935  10.85404  13.29497  1.000 38.08624  ? 208 ILE B CD1 1 
ATOM   3482 N N   . LEU B 1 209 ? 43.06839  13.96596  9.96225   1.000 33.24782  ? 209 LEU B N   1 
ATOM   3483 C CA  . LEU B 1 209 ? 42.31811  13.44019  8.83650   1.000 33.38705  ? 209 LEU B CA  1 
ATOM   3484 C C   . LEU B 1 209 ? 42.70029  11.98136  8.70512   1.000 31.72715  ? 209 LEU B C   1 
ATOM   3485 O O   . LEU B 1 209 ? 43.70035  11.52626  9.26460   1.000 30.81673  ? 209 LEU B O   1 
ATOM   3486 C CB  . LEU B 1 209 ? 42.60913  14.20309  7.52723   1.000 37.63986  ? 209 LEU B CB  1 
ATOM   3487 C CG  . LEU B 1 209 ? 42.35337  15.71769  7.54838   1.000 37.87334  ? 209 LEU B CG  1 
ATOM   3488 C CD1 . LEU B 1 209 ? 42.86171  16.37493  6.25931   1.000 38.44589  ? 209 LEU B CD1 1 
ATOM   3489 C CD2 . LEU B 1 209 ? 40.86908  16.03761  7.78576   1.000 34.80325  ? 209 LEU B CD2 1 
ATOM   3490 N N   . HIS B 1 210 ? 41.88999  11.23566  7.98165   1.000 28.51250  ? 210 HIS B N   1 
ATOM   3491 C CA  . HIS B 1 210 ? 42.14950  9.81458   7.91353   1.000 30.87585  ? 210 HIS B CA  1 
ATOM   3492 C C   . HIS B 1 210 ? 41.64584  9.29091   6.57927   1.000 30.98221  ? 210 HIS B C   1 
ATOM   3493 O O   . HIS B 1 210 ? 40.86494  9.94724   5.88362   1.000 32.63270  ? 210 HIS B O   1 
ATOM   3494 C CB  . HIS B 1 210 ? 41.48850  9.06482   9.07078   1.000 31.50692  ? 210 HIS B CB  1 
ATOM   3495 C CG  . HIS B 1 210 ? 40.00657  8.98874   8.93908   1.000 30.39531  ? 210 HIS B CG  1 
ATOM   3496 N ND1 . HIS B 1 210 ? 39.16195  9.94601   9.46050   1.000 31.07434  ? 210 HIS B ND1 1 
ATOM   3497 C CD2 . HIS B 1 210 ? 39.21903  8.09087   8.30798   1.000 34.10544  ? 210 HIS B CD2 1 
ATOM   3498 C CE1 . HIS B 1 210 ? 37.91262  9.63608   9.16295   1.000 35.22006  ? 210 HIS B CE1 1 
ATOM   3499 N NE2 . HIS B 1 210 ? 37.92096  8.51546   8.46208   1.000 32.37147  ? 210 HIS B NE2 1 
ATOM   3500 N N   . ALA B 1 211 ? 42.11930  8.09134   6.24358   1.000 32.65510  ? 211 ALA B N   1 
ATOM   3501 C CA  . ALA B 1 211 ? 41.69154  7.33796   5.07463   1.000 34.14185  ? 211 ALA B CA  1 
ATOM   3502 C C   . ALA B 1 211 ? 42.11417  5.90008   5.28996   1.000 35.17616  ? 211 ALA B C   1 
ATOM   3503 O O   . ALA B 1 211 ? 42.88371  5.58301   6.20433   1.000 33.46450  ? 211 ALA B O   1 
ATOM   3504 C CB  . ALA B 1 211 ? 42.30822  7.87410   3.77042   1.000 34.24712  ? 211 ALA B CB  1 
ATOM   3505 N N   . VAL B 1 212 ? 41.63576  5.03805   4.40083   1.000 27.89070  ? 212 VAL B N   1 
ATOM   3506 C CA  . VAL B 1 212 ? 41.96920  3.62564   4.38875   1.000 29.19698  ? 212 VAL B CA  1 
ATOM   3507 C C   . VAL B 1 212 ? 42.31283  3.26240   2.95841   1.000 32.96497  ? 212 VAL B C   1 
ATOM   3508 O O   . VAL B 1 212 ? 41.64626  3.71754   2.02240   1.000 26.86646  ? 212 VAL B O   1 
ATOM   3509 C CB  . VAL B 1 212 ? 40.79068  2.76377   4.88284   1.000 33.27766  ? 212 VAL B CB  1 
ATOM   3510 C CG1 . VAL B 1 212 ? 41.17204  1.30052   4.95373   1.000 26.19673  ? 212 VAL B CG1 1 
ATOM   3511 C CG2 . VAL B 1 212 ? 40.38326  3.27422   6.22555   1.000 40.27365  ? 212 VAL B CG2 1 
ATOM   3512 N N   . ARG B 1 213 ? 43.32754  2.45598   2.79463   1.000 31.07275  ? 213 ARG B N   1 
ATOM   3513 C CA  . ARG B 1 213 ? 43.72781  2.05682   1.45935   1.000 31.37134  ? 213 ARG B CA  1 
ATOM   3514 C C   . ARG B 1 213 ? 42.78885  0.98150   0.92653   1.000 30.02880  ? 213 ARG B C   1 
ATOM   3515 O O   . ARG B 1 213 ? 42.18491  0.23893   1.70587   1.000 28.60306  ? 213 ARG B O   1 
ATOM   3516 C CB  . ARG B 1 213 ? 45.16201  1.54767   1.48667   1.000 30.90576  ? 213 ARG B CB  1 
ATOM   3517 C CG  . ARG B 1 213 ? 46.11460  2.70069   1.77724   1.000 37.67457  ? 213 ARG B CG  1 
ATOM   3518 C CD  . ARG B 1 213 ? 47.52739  2.51495   1.22000   1.000 39.96425  ? 213 ARG B CD  1 
ATOM   3519 N NE  . ARG B 1 213 ? 47.60771  1.68983   0.02077   1.000 33.58404  ? 213 ARG B NE  1 
ATOM   3520 C CZ  . ARG B 1 213 ? 47.77172  2.14569   -1.21145  1.000 41.54157  ? 213 ARG B CZ  1 
ATOM   3521 N NH1 . ARG B 1 213 ? 47.83258  3.45034   -1.46876  1.000 41.44194  ? 213 ARG B NH1 1 
ATOM   3522 N NH2 . ARG B 1 213 ? 47.89390  1.26943   -2.21153  1.000 40.99884  ? 213 ARG B NH2 1 
ATOM   3523 N N   . PRO B 1 214 ? 42.64844  0.88585   -0.39518  1.000 31.59178  ? 214 PRO B N   1 
ATOM   3524 C CA  . PRO B 1 214 ? 41.85491  -0.20555  -0.98617  1.000 31.13208  ? 214 PRO B CA  1 
ATOM   3525 C C   . PRO B 1 214 ? 42.31069  -1.56300  -0.48774  1.000 29.42647  ? 214 PRO B C   1 
ATOM   3526 O O   . PRO B 1 214 ? 43.48974  -1.77518  -0.20710  1.000 30.91576  ? 214 PRO B O   1 
ATOM   3527 C CB  . PRO B 1 214 ? 42.11959  -0.06620  -2.49305  1.000 29.22003  ? 214 PRO B CB  1 
ATOM   3528 C CG  . PRO B 1 214 ? 42.62209  1.39487   -2.66112  1.000 30.07159  ? 214 PRO B CG  1 
ATOM   3529 C CD  . PRO B 1 214 ? 43.31501  1.73383   -1.40237  1.000 32.23349  ? 214 PRO B CD  1 
ATOM   3530 N N   . ILE B 1 215 ? 41.37339  -2.49861  -0.39219  1.000 24.01609  ? 215 ILE B N   1 
ATOM   3531 C CA  . ILE B 1 215 ? 41.74708  -3.89593  -0.23437  1.000 32.35644  ? 215 ILE B CA  1 
ATOM   3532 C C   . ILE B 1 215 ? 41.69531  -4.53558  -1.62218  1.000 39.45710  ? 215 ILE B C   1 
ATOM   3533 O O   . ILE B 1 215 ? 41.04907  -4.02795  -2.54998  1.000 32.74596  ? 215 ILE B O   1 
ATOM   3534 C CB  . ILE B 1 215 ? 40.85953  -4.67594  0.77242   1.000 29.42348  ? 215 ILE B CB  1 
ATOM   3535 C CG1 . ILE B 1 215 ? 39.41434  -4.79331  0.25925   1.000 32.16867  ? 215 ILE B CG1 1 
ATOM   3536 C CG2 . ILE B 1 215 ? 40.87298  -4.01983  2.14907   1.000 30.45560  ? 215 ILE B CG2 1 
ATOM   3537 C CD1 . ILE B 1 215 ? 38.52598  -5.69071  1.14602   1.000 29.77076  ? 215 ILE B CD1 1 
ATOM   3538 N N   . HIS B 1 216 ? 42.41953  -5.64271  -1.77819  1.000 36.39111  ? 216 HIS B N   1 
ATOM   3539 C CA  . HIS B 1 216 ? 42.37848  -6.44784  -2.99416  1.000 40.54248  ? 216 HIS B CA  1 
ATOM   3540 C C   . HIS B 1 216 ? 42.69824  -7.88795  -2.63014  1.000 39.48818  ? 216 HIS B C   1 
ATOM   3541 O O   . HIS B 1 216 ? 43.37706  -8.13725  -1.62379  1.000 38.19447  ? 216 HIS B O   1 
ATOM   3542 C CB  . HIS B 1 216 ? 43.34105  -5.92085  -4.07177  1.000 40.36765  ? 216 HIS B CB  1 
ATOM   3543 C CG  . HIS B 1 216 ? 44.70077  -5.58307  -3.56912  1.000 46.08137  ? 216 HIS B CG  1 
ATOM   3544 N ND1 . HIS B 1 216 ? 45.72050  -6.50930  -3.50414  1.000 59.49766  ? 216 HIS B ND1 1 
ATOM   3545 C CD2 . HIS B 1 216 ? 45.21903  -4.41635  -3.11543  1.000 52.63861  ? 216 HIS B CD2 1 
ATOM   3546 C CE1 . HIS B 1 216 ? 46.80849  -5.92974  -3.02517  1.000 63.05003  ? 216 HIS B CE1 1 
ATOM   3547 N NE2 . HIS B 1 216 ? 46.52888  -4.66185  -2.77511  1.000 71.47601  ? 216 HIS B NE2 1 
ATOM   3548 N N   . PRO B 1 217 ? 42.20433  -8.85583  -3.40002  1.000 39.05022  ? 217 PRO B N   1 
ATOM   3549 C CA  . PRO B 1 217 ? 42.32938  -10.25776 -2.97530  1.000 41.26000  ? 217 PRO B CA  1 
ATOM   3550 C C   . PRO B 1 217 ? 43.76705  -10.75849 -3.00212  1.000 39.56742  ? 217 PRO B C   1 
ATOM   3551 O O   . PRO B 1 217 ? 44.59130  -10.33007 -3.80975  1.000 40.89468  ? 217 PRO B O   1 
ATOM   3552 C CB  . PRO B 1 217 ? 41.45194  -11.02854 -3.97452  1.000 38.38050  ? 217 PRO B CB  1 
ATOM   3553 C CG  . PRO B 1 217 ? 41.15906  -10.10089 -5.08495  1.000 41.78209  ? 217 PRO B CG  1 
ATOM   3554 C CD  . PRO B 1 217 ? 41.40729  -8.69094  -4.63028  1.000 41.12125  ? 217 PRO B CD  1 
ATOM   3555 N N   . VAL B 1 218 ? 44.06491  -11.66374 -2.07526  1.000 45.57626  ? 218 VAL B N   1 
ATOM   3556 C CA  . VAL B 1 218 ? 45.31001  -12.42438 -2.13580  1.000 46.47102  ? 218 VAL B CA  1 
ATOM   3557 C C   . VAL B 1 218 ? 45.18352  -13.55975 -3.14868  1.000 54.76601  ? 218 VAL B C   1 
ATOM   3558 O O   . VAL B 1 218 ? 45.89122  -13.58982 -4.16136  1.000 56.98052  ? 218 VAL B O   1 
ATOM   3559 C CB  . VAL B 1 218 ? 45.68929  -12.94507 -0.73668  1.000 41.23351  ? 218 VAL B CB  1 
ATOM   3560 C CG1 . VAL B 1 218 ? 47.00079  -13.72720 -0.78214  1.000 42.16651  ? 218 VAL B CG1 1 
ATOM   3561 C CG2 . VAL B 1 218 ? 45.81957  -11.78023 0.23684   1.000 42.40857  ? 218 VAL B CG2 1 
ATOM   3562 N N   . ASP B 1 219 ? 44.25493  -14.49834 -2.89860  1.000 46.41950  ? 219 ASP B N   1 
ATOM   3563 C CA  . ASP B 1 219 ? 43.85266  -15.53366 -3.84477  1.000 50.15687  ? 219 ASP B CA  1 
ATOM   3564 C C   . ASP B 1 219 ? 42.89908  -14.95136 -4.88949  1.000 54.26525  ? 219 ASP B C   1 
ATOM   3565 O O   . ASP B 1 219 ? 41.75566  -14.59511 -4.56428  1.000 43.93723  ? 219 ASP B O   1 
ATOM   3566 C CB  . ASP B 1 219 ? 43.19479  -16.69566 -3.09666  1.000 53.42377  ? 219 ASP B CB  1 
ATOM   3567 C CG  . ASP B 1 219 ? 42.58984  -17.72840 -4.02673  1.000 52.78223  ? 219 ASP B CG  1 
ATOM   3568 O OD1 . ASP B 1 219 ? 42.76548  -17.60149 -5.25479  1.000 51.63642  ? 219 ASP B OD1 1 
ATOM   3569 O OD2 . ASP B 1 219 ? 41.92967  -18.66709 -3.52586  1.000 51.62033  ? 219 ASP B OD2 1 
ATOM   3570 N N   . PRO B 1 220 ? 43.31158  -14.88761 -6.17008  1.000 54.69675  ? 220 PRO B N   1 
ATOM   3571 C CA  . PRO B 1 220 ? 42.53068  -14.12984 -7.16058  1.000 48.72033  ? 220 PRO B CA  1 
ATOM   3572 C C   . PRO B 1 220 ? 41.28505  -14.85678 -7.65071  1.000 45.17028  ? 220 PRO B C   1 
ATOM   3573 O O   . PRO B 1 220 ? 40.64376  -14.39821 -8.59358  1.000 49.18696  ? 220 PRO B O   1 
ATOM   3574 C CB  . PRO B 1 220 ? 43.53374  -13.90005 -8.29900  1.000 55.79184  ? 220 PRO B CB  1 
ATOM   3575 C CG  . PRO B 1 220 ? 44.89882  -14.21855 -7.69644  1.000 64.07643  ? 220 PRO B CG  1 
ATOM   3576 C CD  . PRO B 1 220 ? 44.61912  -15.29626 -6.69887  1.000 60.29900  ? 220 PRO B CD  1 
ATOM   3577 N N   . THR B 1 221 ? 40.92946  -15.98426 -7.04197  1.000 45.63472  ? 221 THR B N   1 
ATOM   3578 C CA  . THR B 1 221 ? 39.67000  -16.64811 -7.35518  1.000 50.97236  ? 221 THR B CA  1 
ATOM   3579 C C   . THR B 1 221 ? 38.54076  -16.27037 -6.40263  1.000 51.24472  ? 221 THR B C   1 
ATOM   3580 O O   . THR B 1 221 ? 37.42800  -16.77985 -6.55505  1.000 40.78306  ? 221 THR B O   1 
ATOM   3581 C CB  . THR B 1 221 ? 39.85086  -18.17205 -7.34658  1.000 51.29592  ? 221 THR B CB  1 
ATOM   3582 O OG1 . THR B 1 221 ? 39.94250  -18.65364 -5.98774  1.000 49.78356  ? 221 THR B OG1 1 
ATOM   3583 C CG2 . THR B 1 221 ? 41.10537  -18.54958 -8.14530  1.000 45.19142  ? 221 THR B CG2 1 
ATOM   3584 N N   . LYS B 1 222 ? 38.79477  -15.39675 -5.43057  1.000 47.60727  ? 222 LYS B N   1 
ATOM   3585 C CA  . LYS B 1 222 ? 37.83148  -15.09136 -4.38456  1.000 41.72249  ? 222 LYS B CA  1 
ATOM   3586 C C   . LYS B 1 222 ? 37.90694  -13.60369 -4.06842  1.000 41.42514  ? 222 LYS B C   1 
ATOM   3587 O O   . LYS B 1 222 ? 38.94071  -12.95734 -4.28295  1.000 33.85848  ? 222 LYS B O   1 
ATOM   3588 C CB  . LYS B 1 222 ? 38.09436  -15.91355 -3.11004  1.000 45.89378  ? 222 LYS B CB  1 
ATOM   3589 C CG  . LYS B 1 222 ? 38.04945  -17.42316 -3.29834  1.000 56.03674  ? 222 LYS B CG  1 
ATOM   3590 C CD  . LYS B 1 222 ? 38.09259  -18.16924 -1.95737  1.000 51.24805  ? 222 LYS B CD  1 
ATOM   3591 C CE  . LYS B 1 222 ? 39.40320  -17.95125 -1.22852  1.000 58.98372  ? 222 LYS B CE  1 
ATOM   3592 N NZ  . LYS B 1 222 ? 39.47650  -18.74557 0.02991   1.000 68.61109  ? 222 LYS B NZ  1 
ATOM   3593 N N   . ALA B 1 223 ? 36.80382  -13.06538 -3.56001  1.000 33.94950  ? 223 ALA B N   1 
ATOM   3594 C CA  . ALA B 1 223 ? 36.78095  -11.65645 -3.20447  1.000 38.68080  ? 223 ALA B CA  1 
ATOM   3595 C C   . ALA B 1 223 ? 37.64977  -11.41125 -1.97363  1.000 34.42100  ? 223 ALA B C   1 
ATOM   3596 O O   . ALA B 1 223 ? 37.91677  -12.32083 -1.18810  1.000 31.55630  ? 223 ALA B O   1 
ATOM   3597 C CB  . ALA B 1 223 ? 35.35281  -11.19456 -2.93365  1.000 33.25791  ? 223 ALA B CB  1 
ATOM   3598 N N   . ALA B 1 224 ? 38.11832  -10.17078 -1.83110  1.000 36.09917  ? 224 ALA B N   1 
ATOM   3599 C CA  . ALA B 1 224 ? 38.62656  -9.69645  -0.54439  1.000 35.87553  ? 224 ALA B CA  1 
ATOM   3600 C C   . ALA B 1 224 ? 37.48531  -9.01501  0.19765   1.000 28.35913  ? 224 ALA B C   1 
ATOM   3601 O O   . ALA B 1 224 ? 36.69472  -8.30632  -0.40632  1.000 27.58622  ? 224 ALA B O   1 
ATOM   3602 C CB  . ALA B 1 224 ? 39.78841  -8.71435  -0.70862  1.000 30.16313  ? 224 ALA B CB  1 
ATOM   3603 N N   . VAL B 1 225 ? 37.42286  -9.23759  1.50755   1.000 26.74663  ? 225 VAL B N   1 
ATOM   3604 C CA  . VAL B 1 225 ? 36.33784  -8.76568  2.36125   1.000 28.85616  ? 225 VAL B CA  1 
ATOM   3605 C C   . VAL B 1 225 ? 36.92985  -8.21733  3.65059   1.000 25.07166  ? 225 VAL B C   1 
ATOM   3606 O O   . VAL B 1 225 ? 37.75586  -8.87213  4.29171   1.000 24.63826  ? 225 VAL B O   1 
ATOM   3607 C CB  . VAL B 1 225 ? 35.34707  -9.89565  2.67945   1.000 30.37785  ? 225 VAL B CB  1 
ATOM   3608 C CG1 . VAL B 1 225 ? 34.21153  -9.38929  3.60517   1.000 27.58491  ? 225 VAL B CG1 1 
ATOM   3609 C CG2 . VAL B 1 225 ? 34.79249  -10.46393 1.38977   1.000 28.59989  ? 225 VAL B CG2 1 
ATOM   3610 N N   . ARG B 1 226 ? 36.47903  -7.04323  4.05260   1.000 25.44999  ? 226 ARG B N   1 
ATOM   3611 C CA  . ARG B 1 226 ? 36.93682  -6.43766  5.29138   1.000 24.65307  ? 226 ARG B CA  1 
ATOM   3612 C C   . ARG B 1 226 ? 35.71762  -5.96081  6.06541   1.000 26.47796  ? 226 ARG B C   1 
ATOM   3613 O O   . ARG B 1 226 ? 34.97698  -5.10931  5.57639   1.000 23.28217  ? 226 ARG B O   1 
ATOM   3614 C CB  . ARG B 1 226 ? 37.88654  -5.27676  4.99853   1.000 23.49419  ? 226 ARG B CB  1 
ATOM   3615 C CG  . ARG B 1 226 ? 38.44627  -4.62168  6.24859   1.000 27.67550  ? 226 ARG B CG  1 
ATOM   3616 C CD  . ARG B 1 226 ? 39.15466  -3.33007  5.87619   1.000 35.30688  ? 226 ARG B CD  1 
ATOM   3617 N NE  . ARG B 1 226 ? 39.94637  -2.77803  6.96556   1.000 32.17005  ? 226 ARG B NE  1 
ATOM   3618 C CZ  . ARG B 1 226 ? 39.79657  -1.56964  7.47923   1.000 33.41742  ? 226 ARG B CZ  1 
ATOM   3619 N NH1 . ARG B 1 226 ? 38.83496  -0.74996  7.06270   1.000 29.06370  ? 226 ARG B NH1 1 
ATOM   3620 N NH2 . ARG B 1 226 ? 40.66229  -1.15385  8.39969   1.000 36.89263  ? 226 ARG B NH2 1 
ATOM   3621 N N   . ASP B 1 227 ? 35.52399  -6.48665  7.27481   1.000 25.83361  ? 227 ASP B N   1 
ATOM   3622 C CA  . ASP B 1 227 ? 34.35079  -6.17569  8.09545   1.000 23.23164  ? 227 ASP B CA  1 
ATOM   3623 C C   . ASP B 1 227 ? 34.74824  -5.26902  9.23662   1.000 24.76654  ? 227 ASP B C   1 
ATOM   3624 O O   . ASP B 1 227 ? 35.59369  -5.63987  10.04636  1.000 22.61384  ? 227 ASP B O   1 
ATOM   3625 C CB  . ASP B 1 227 ? 33.71497  -7.42407  8.70483   1.000 19.01511  ? 227 ASP B CB  1 
ATOM   3626 C CG  . ASP B 1 227 ? 33.06888  -8.31552  7.66158   1.000 26.55841  ? 227 ASP B CG  1 
ATOM   3627 O OD1 . ASP B 1 227 ? 32.70417  -7.81374  6.55861   1.000 24.97843  ? 227 ASP B OD1 1 
ATOM   3628 O OD2 . ASP B 1 227 ? 32.88418  -9.51152  7.97296   1.000 30.41047  ? 227 ASP B OD2 1 
ATOM   3629 N N   . VAL B 1 228 ? 34.02422  -4.16656  9.38267   1.000 22.38080  ? 228 VAL B N   1 
ATOM   3630 C CA  . VAL B 1 228 ? 34.42753  -3.11630  10.28401  1.000 20.83130  ? 228 VAL B CA  1 
ATOM   3631 C C   . VAL B 1 228 ? 33.19976  -2.58640  11.01358  1.000 19.71979  ? 228 VAL B C   1 
ATOM   3632 O O   . VAL B 1 228 ? 32.10652  -2.51263  10.43595  1.000 18.11739  ? 228 VAL B O   1 
ATOM   3633 C CB  . VAL B 1 228 ? 35.16724  -2.08836  9.40501   1.000 27.79255  ? 228 VAL B CB  1 
ATOM   3634 C CG1 . VAL B 1 228 ? 34.63990  -0.77970  9.51933   1.000 27.32661  ? 228 VAL B CG1 1 
ATOM   3635 C CG2 . VAL B 1 228 ? 36.68208  -2.26317  9.53101   1.000 21.03689  ? 228 VAL B CG2 1 
ATOM   3636 N N   . LEU B 1 229 ? 33.36900  -2.27513  12.29784  1.000 17.65476  ? 229 LEU B N   1 
ATOM   3637 C CA  . LEU B 1 229 ? 32.37270  -1.58225  13.11990  1.000 18.09058  ? 229 LEU B CA  1 
ATOM   3638 C C   . LEU B 1 229 ? 32.94666  -0.20881  13.49065  1.000 20.90066  ? 229 LEU B C   1 
ATOM   3639 O O   . LEU B 1 229 ? 34.01841  -0.11709  14.11466  1.000 20.12154  ? 229 LEU B O   1 
ATOM   3640 C CB  . LEU B 1 229 ? 32.04224  -2.40375  14.38493  1.000 18.79468  ? 229 LEU B CB  1 
ATOM   3641 C CG  . LEU B 1 229 ? 31.21777  -1.74384  15.49791  1.000 21.78044  ? 229 LEU B CG  1 
ATOM   3642 C CD1 . LEU B 1 229 ? 29.85473  -1.31157  14.92403  1.000 18.02250  ? 229 LEU B CD1 1 
ATOM   3643 C CD2 . LEU B 1 229 ? 31.00879  -2.66631  16.74080  1.000 18.44437  ? 229 LEU B CD2 1 
ATOM   3644 N N   . ILE B 1 230 ? 32.24262  0.84916   13.11360  1.000 16.66590  ? 230 ILE B N   1 
ATOM   3645 C CA  . ILE B 1 230 ? 32.66785  2.22936   13.36474  1.000 20.56687  ? 230 ILE B CA  1 
ATOM   3646 C C   . ILE B 1 230 ? 31.58491  2.96389   14.15447  1.000 18.74228  ? 230 ILE B C   1 
ATOM   3647 O O   . ILE B 1 230 ? 30.41887  2.94388   13.77251  1.000 19.86500  ? 230 ILE B O   1 
ATOM   3648 C CB  . ILE B 1 230 ? 32.94447  2.96575   12.04393  1.000 20.55926  ? 230 ILE B CB  1 
ATOM   3649 C CG1 . ILE B 1 230 ? 34.07443  2.25035   11.25076  1.000 22.80241  ? 230 ILE B CG1 1 
ATOM   3650 C CG2 . ILE B 1 230 ? 33.19512  4.44072   12.28200  1.000 19.99082  ? 230 ILE B CG2 1 
ATOM   3651 C CD1 . ILE B 1 230 ? 34.22004  2.77090   9.79376   1.000 28.54026  ? 230 ILE B CD1 1 
ATOM   3652 N N   . MET B 1 231 ? 31.98236  3.65803   15.21447  1.000 19.63949  ? 231 MET B N   1 
ATOM   3653 C CA  . MET B 1 231 ? 31.07790  4.52806   15.93136  1.000 19.43472  ? 231 MET B CA  1 
ATOM   3654 C C   . MET B 1 231 ? 31.62492  5.94322   15.97514  1.000 18.68125  ? 231 MET B C   1 
ATOM   3655 O O   . MET B 1 231 ? 32.83475  6.15806   16.14840  1.000 22.62847  ? 231 MET B O   1 
ATOM   3656 C CB  . MET B 1 231 ? 30.81687  3.96049   17.34348  1.000 15.82280  ? 231 MET B CB  1 
ATOM   3657 C CG  . MET B 1 231 ? 29.97059  2.69379   17.28265  1.000 23.27897  ? 231 MET B CG  1 
ATOM   3658 S SD  . MET B 1 231 ? 29.53331  2.10924   18.95880  1.000 26.14940  ? 231 MET B SD  1 
ATOM   3659 C CE  . MET B 1 231 ? 31.11877  1.48988   19.51456  1.000 23.25566  ? 231 MET B CE  1 
ATOM   3660 N N   . GLY B 1 232 ? 30.76389  6.91710   15.74505  1.000 19.71318  ? 232 GLY B N   1 
ATOM   3661 C CA  . GLY B 1 232 ? 31.15225  8.30603   15.84374  1.000 22.05601  ? 232 GLY B CA  1 
ATOM   3662 C C   . GLY B 1 232 ? 30.33715  8.99387   16.90856  1.000 22.51415  ? 232 GLY B C   1 
ATOM   3663 O O   . GLY B 1 232 ? 29.11776  8.84427   16.94621  1.000 20.46802  ? 232 GLY B O   1 
ATOM   3664 N N   . TYR B 1 233 ? 31.01175  9.77762   17.74811  1.000 20.27736  ? 233 TYR B N   1 
ATOM   3665 C CA  . TYR B 1 233 ? 30.38518  10.42664  18.89380  1.000 18.67010  ? 233 TYR B CA  1 
ATOM   3666 C C   . TYR B 1 233 ? 30.43555  11.93469  18.72187  1.000 21.71093  ? 233 TYR B C   1 
ATOM   3667 O O   . TYR B 1 233 ? 31.51761  12.49538  18.51852  1.000 24.02490  ? 233 TYR B O   1 
ATOM   3668 C CB  . TYR B 1 233 ? 31.10971  10.06578  20.18366  1.000 20.81218  ? 233 TYR B CB  1 
ATOM   3669 C CG  . TYR B 1 233 ? 31.21291  8.58745   20.53466  1.000 23.30460  ? 233 TYR B CG  1 
ATOM   3670 C CD1 . TYR B 1 233 ? 31.98473  7.71048   19.77931  1.000 16.79471  ? 233 TYR B CD1 1 
ATOM   3671 C CD2 . TYR B 1 233 ? 30.58456  8.09610   21.67966  1.000 18.49930  ? 233 TYR B CD2 1 
ATOM   3672 C CE1 . TYR B 1 233 ? 32.08780  6.35668   20.13104  1.000 18.76552  ? 233 TYR B CE1 1 
ATOM   3673 C CE2 . TYR B 1 233 ? 30.70315  6.73969   22.06655  1.000 18.61507  ? 233 TYR B CE2 1 
ATOM   3674 C CZ  . TYR B 1 233 ? 31.46046  5.88156   21.29060  1.000 18.46835  ? 233 TYR B CZ  1 
ATOM   3675 O OH  . TYR B 1 233 ? 31.57803  4.53466   21.66037  1.000 17.56904  ? 233 TYR B OH  1 
ATOM   3676 N N   . LYS B 1 234 ? 29.28695  12.59540  18.82820  1.000 22.98486  ? 234 LYS B N   1 
ATOM   3677 C CA  . LYS B 1 234 ? 29.24071  14.04472  18.72003  1.000 20.31107  ? 234 LYS B CA  1 
ATOM   3678 C C   . LYS B 1 234 ? 28.48526  14.63281  19.91078  1.000 29.27138  ? 234 LYS B C   1 
ATOM   3679 O O   . LYS B 1 234 ? 27.35604  14.22145  20.20567  1.000 20.53844  ? 234 LYS B O   1 
ATOM   3680 C CB  . LYS B 1 234 ? 28.57249  14.47272  17.41480  1.000 25.01868  ? 234 LYS B CB  1 
ATOM   3681 C CG  . LYS B 1 234 ? 28.99835  15.85573  17.00749  1.000 40.40175  ? 234 LYS B CG  1 
ATOM   3682 C CD  . LYS B 1 234 ? 28.43643  16.26086  15.65528  1.000 52.58585  ? 234 LYS B CD  1 
ATOM   3683 C CE  . LYS B 1 234 ? 28.99889  17.62094  15.26889  1.000 61.13332  ? 234 LYS B CE  1 
ATOM   3684 N NZ  . LYS B 1 234 ? 28.63050  18.65006  16.29149  1.000 60.87113  ? 234 LYS B NZ  1 
ATOM   3685 N N   . HIS B 1 235 ? 29.10020  15.60971  20.56600  1.000 26.26679  ? 235 HIS B N   1 
ATOM   3686 C CA  . HIS B 1 235 ? 28.51519  16.26708  21.73360  1.000 22.69272  ? 235 HIS B CA  1 
ATOM   3687 C C   . HIS B 1 235 ? 27.32155  17.08993  21.28509  1.000 28.16612  ? 235 HIS B C   1 
ATOM   3688 O O   . HIS B 1 235 ? 27.45514  17.92301  20.39060  1.000 24.97126  ? 235 HIS B O   1 
ATOM   3689 C CB  . HIS B 1 235 ? 29.56992  17.14866  22.40053  1.000 30.88777  ? 235 HIS B CB  1 
ATOM   3690 C CG  . HIS B 1 235 ? 29.07746  17.89468  23.60894  1.000 34.80127  ? 235 HIS B CG  1 
ATOM   3691 N ND1 . HIS B 1 235 ? 29.26659  19.25304  23.76843  1.000 32.28547  ? 235 HIS B ND1 1 
ATOM   3692 C CD2 . HIS B 1 235 ? 28.41597  17.47330  24.71956  1.000 29.45601  ? 235 HIS B CD2 1 
ATOM   3693 C CE1 . HIS B 1 235 ? 28.76085  19.63214  24.93211  1.000 31.30347  ? 235 HIS B CE1 1 
ATOM   3694 N NE2 . HIS B 1 235 ? 28.22708  18.57340  25.52192  1.000 32.14547  ? 235 HIS B NE2 1 
ATOM   3695 N N   . GLU B 1 236 ? 26.14634  16.83632  21.85220  1.000 23.86798  ? 236 GLU B N   1 
ATOM   3696 C CA  . GLU B 1 236 ? 24.90848  17.49897  21.41259  1.000 31.25256  ? 236 GLU B CA  1 
ATOM   3697 C C   . GLU B 1 236 ? 24.08526  17.96620  22.60181  1.000 30.68662  ? 236 GLU B C   1 
ATOM   3698 O O   . GLU B 1 236 ? 23.03219  17.39194  22.91661  1.000 30.66441  ? 236 GLU B O   1 
ATOM   3699 C CB  . GLU B 1 236 ? 24.07026  16.58235  20.52396  1.000 29.29767  ? 236 GLU B CB  1 
ATOM   3700 C CG  . GLU B 1 236 ? 24.73744  16.19781  19.22036  1.000 31.29729  ? 236 GLU B CG  1 
ATOM   3701 C CD  . GLU B 1 236 ? 24.77863  17.33480  18.19864  1.000 45.51905  ? 236 GLU B CD  1 
ATOM   3702 O OE1 . GLU B 1 236 ? 24.17179  18.41532  18.44685  1.000 41.98914  ? 236 GLU B OE1 1 
ATOM   3703 O OE2 . GLU B 1 236 ? 25.43475  17.13896  17.14750  1.000 44.25159  ? 236 GLU B OE2 1 
ATOM   3704 N N   . PRO B 1 237 ? 24.51111  19.04928  23.25372  1.000 35.07311  ? 237 PRO B N   1 
ATOM   3705 C CA  . PRO B 1 237 ? 23.81118  19.50766  24.46176  1.000 33.67787  ? 237 PRO B CA  1 
ATOM   3706 C C   . PRO B 1 237 ? 22.33119  19.78077  24.28261  1.000 33.03322  ? 237 PRO B C   1 
ATOM   3707 O O   . PRO B 1 237 ? 21.61634  19.71454  25.27770  1.000 35.29555  ? 237 PRO B O   1 
ATOM   3708 C CB  . PRO B 1 237 ? 24.56472  20.79071  24.84537  1.000 35.08109  ? 237 PRO B CB  1 
ATOM   3709 C CG  . PRO B 1 237 ? 25.36052  21.17580  23.61252  1.000 35.41130  ? 237 PRO B CG  1 
ATOM   3710 C CD  . PRO B 1 237 ? 25.70560  19.86971  22.96567  1.000 32.17470  ? 237 PRO B CD  1 
ATOM   3711 N N   . GLU B 1 238 ? 21.83150  20.07395  23.07698  1.000 32.56465  ? 238 GLU B N   1 
ATOM   3712 C CA  . GLU B 1 238 ? 20.41213  20.37357  22.91639  1.000 39.34968  ? 238 GLU B CA  1 
ATOM   3713 C C   . GLU B 1 238 ? 19.60695  19.15626  22.51038  1.000 36.36286  ? 238 GLU B C   1 
ATOM   3714 O O   . GLU B 1 238 ? 18.39495  19.24692  22.39455  1.000 27.27618  ? 238 GLU B O   1 
ATOM   3715 C CB  . GLU B 1 238 ? 20.18646  21.48304  21.87414  1.000 38.81843  ? 238 GLU B CB  1 
ATOM   3716 C CG  . GLU B 1 238 ? 20.82703  22.80119  22.22414  1.000 50.16144  ? 238 GLU B CG  1 
ATOM   3717 C CD  . GLU B 1 238 ? 20.57133  23.16891  23.66412  1.000 61.97478  ? 238 GLU B CD  1 
ATOM   3718 O OE1 . GLU B 1 238 ? 19.38427  23.31641  24.02927  1.000 74.80601  ? 238 GLU B OE1 1 
ATOM   3719 O OE2 . GLU B 1 238 ? 21.54795  23.28275  24.43959  1.000 66.80780  ? 238 GLU B OE2 1 
ATOM   3720 N N   . LEU B 1 239 ? 20.24771  18.03103  22.25972  1.000 31.89011  ? 239 LEU B N   1 
ATOM   3721 C CA  . LEU B 1 239 ? 19.51163  16.85891  21.81068  1.000 26.29645  ? 239 LEU B CA  1 
ATOM   3722 C C   . LEU B 1 239 ? 18.49823  16.42236  22.86408  1.000 27.77500  ? 239 LEU B C   1 
ATOM   3723 O O   . LEU B 1 239 ? 18.80212  16.38644  24.05216  1.000 27.46212  ? 239 LEU B O   1 
ATOM   3724 C CB  . LEU B 1 239 ? 20.50323  15.74031  21.51138  1.000 25.01734  ? 239 LEU B CB  1 
ATOM   3725 C CG  . LEU B 1 239 ? 19.85737  14.42584  21.10654  1.000 31.69725  ? 239 LEU B CG  1 
ATOM   3726 C CD1 . LEU B 1 239 ? 18.91284  14.60963  19.86789  1.000 26.41414  ? 239 LEU B CD1 1 
ATOM   3727 C CD2 . LEU B 1 239 ? 20.99647  13.45780  20.85743  1.000 28.08310  ? 239 LEU B CD2 1 
ATOM   3728 N N   . ARG B 1 240 ? 17.28911  16.09835  22.42603  1.000 33.78145  ? 240 ARG B N   1 
ATOM   3729 C CA  . ARG B 1 240 ? 16.21497  15.64916  23.30313  1.000 36.08159  ? 240 ARG B CA  1 
ATOM   3730 C C   . ARG B 1 240 ? 15.92627  14.16791  23.07432  1.000 30.83694  ? 240 ARG B C   1 
ATOM   3731 O O   . ARG B 1 240 ? 16.27440  13.60094  22.03848  1.000 30.71930  ? 240 ARG B O   1 
ATOM   3732 C CB  . ARG B 1 240 ? 14.93755  16.46483  23.06019  1.000 34.90779  ? 240 ARG B CB  1 
ATOM   3733 C CG  . ARG B 1 240 ? 15.10079  17.95090  23.33032  1.000 49.36280  ? 240 ARG B CG  1 
ATOM   3734 C CD  . ARG B 1 240 ? 14.75190  18.24979  24.76568  1.000 53.24563  ? 240 ARG B CD  1 
ATOM   3735 N NE  . ARG B 1 240 ? 13.35955  17.91352  25.04198  1.000 69.47592  ? 240 ARG B NE  1 
ATOM   3736 C CZ  . ARG B 1 240 ? 12.89520  17.53423  26.22604  1.000 68.50370  ? 240 ARG B CZ  1 
ATOM   3737 N NH1 . ARG B 1 240 ? 13.69405  17.41415  27.27777  1.000 70.68972  ? 240 ARG B NH1 1 
ATOM   3738 N NH2 . ARG B 1 240 ? 11.60101  17.24958  26.35417  1.000 59.87355  ? 240 ARG B NH2 1 
ATOM   3739 N N   . ARG B 1 241 ? 15.26903  13.53969  24.04824  1.000 29.96607  ? 241 ARG B N   1 
ATOM   3740 C CA  . ARG B 1 241 ? 14.80244  12.17243  23.85105  1.000 26.80787  ? 241 ARG B CA  1 
ATOM   3741 C C   . ARG B 1 241 ? 13.62152  12.14539  22.89121  1.000 30.81949  ? 241 ARG B C   1 
ATOM   3742 O O   . ARG B 1 241 ? 12.78211  13.04585  22.88971  1.000 34.24711  ? 241 ARG B O   1 
ATOM   3743 C CB  . ARG B 1 241 ? 14.43392  11.53749  25.19346  1.000 27.84481  ? 241 ARG B CB  1 
ATOM   3744 C CG  . ARG B 1 241 ? 15.65702  11.40395  26.10955  1.000 23.49710  ? 241 ARG B CG  1 
ATOM   3745 C CD  . ARG B 1 241 ? 15.21178  10.96762  27.51495  1.000 26.20006  ? 241 ARG B CD  1 
ATOM   3746 N NE  . ARG B 1 241 ? 16.33642  10.94078  28.43651  1.000 31.81131  ? 241 ARG B NE  1 
ATOM   3747 C CZ  . ARG B 1 241 ? 16.83279  12.00371  29.05806  1.000 35.42084  ? 241 ARG B CZ  1 
ATOM   3748 N NH1 . ARG B 1 241 ? 16.26965  13.20122  28.94183  1.000 32.40388  ? 241 ARG B NH1 1 
ATOM   3749 N NH2 . ARG B 1 241 ? 17.93793  11.86933  29.79811  1.000 28.92849  ? 241 ARG B NH2 1 
ATOM   3750 N N   . GLU B 1 242 ? 13.57618  11.11407  22.05529  1.000 27.31172  ? 242 GLU B N   1 
ATOM   3751 C CA  . GLU B 1 242 ? 12.57732  10.97357  21.01102  1.000 33.69667  ? 242 GLU B CA  1 
ATOM   3752 C C   . GLU B 1 242 ? 11.72633  9.74780   21.31119  1.000 36.59733  ? 242 GLU B C   1 
ATOM   3753 O O   . GLU B 1 242 ? 12.25230  8.69722   21.70125  1.000 32.06281  ? 242 GLU B O   1 
ATOM   3754 C CB  . GLU B 1 242 ? 13.22254  10.84075  19.61683  1.000 26.16782  ? 242 GLU B CB  1 
ATOM   3755 C CG  . GLU B 1 242 ? 13.88302  12.14889  19.11439  1.000 33.04329  ? 242 GLU B CG  1 
ATOM   3756 C CD  . GLU B 1 242 ? 15.00182  11.89698  18.07609  1.000 35.34972  ? 242 GLU B CD  1 
ATOM   3757 O OE1 . GLU B 1 242 ? 15.99167  11.19237  18.39108  1.000 37.54091  ? 242 GLU B OE1 1 
ATOM   3758 O OE2 . GLU B 1 242 ? 14.90508  12.40575  16.94293  1.000 46.55608  ? 242 GLU B OE2 1 
ATOM   3759 N N   . GLU B 1 243 ? 10.41344  9.89950   21.12789  1.000 44.73161  ? 243 GLU B N   1 
ATOM   3760 C CA  . GLU B 1 243 ? 9.42382   8.89405   21.51739  1.000 59.27601  ? 243 GLU B CA  1 
ATOM   3761 C C   . GLU B 1 243 ? 8.60540   8.41219   20.31374  1.000 61.71077  ? 243 GLU B C   1 
ATOM   3762 O O   . GLU B 1 243 ? 8.70115   7.24893   19.90545  1.000 64.46733  ? 243 GLU B O   1 
ATOM   3763 C CB  . GLU B 1 243 ? 8.48207   9.45560   22.60537  1.000 53.60667  ? 243 GLU B CB  1 
ATOM   3764 C CG  . GLU B 1 243 ? 9.12224   9.69288   23.98176  1.000 40.17451  ? 243 GLU B CG  1 
ATOM   3765 C CD  . GLU B 1 243 ? 9.52602   8.38567   24.67199  1.000 39.34016  ? 243 GLU B CD  1 
ATOM   3766 O OE1 . GLU B 1 243 ? 8.92666   7.33510   24.35746  1.000 47.02386  ? 243 GLU B OE1 1 
ATOM   3767 O OE2 . GLU B 1 243 ? 10.44316  8.40695   25.52557  1.000 36.63035  ? 243 GLU B OE2 1 
HETATM 3768 C C1  . SIN C 2 .   ? 14.16999  -5.19477  39.79740  1.000 65.81601  ? 301 SIN A C1  1 
HETATM 3769 O O1  . SIN C 2 .   ? 13.84399  -5.35539  40.99767  1.000 72.36601  ? 301 SIN A O1  1 
HETATM 3770 O O2  . SIN C 2 .   ? 13.26873  -5.29979  38.93285  1.000 38.15499  ? 301 SIN A O2  1 
HETATM 3771 C C2  . SIN C 2 .   ? 15.62209  -4.92131  39.42787  1.000 56.88327  ? 301 SIN A C2  1 
HETATM 3772 C C3  . SIN C 2 .   ? 15.87376  -3.51127  38.85722  1.000 54.71800  ? 301 SIN A C3  1 
HETATM 3773 C C4  . SIN C 2 .   ? 17.33764  -3.06982  38.99123  1.000 63.61601  ? 301 SIN A C4  1 
HETATM 3774 O O3  . SIN C 2 .   ? 17.88324  -2.18029  38.23242  1.000 40.33379  ? 301 SIN A O3  1 
HETATM 3775 O O4  . SIN C 2 .   ? 18.02869  -3.60900  39.90140  1.000 35.46096  ? 301 SIN A O4  1 
HETATM 3776 O O1  . VVO D 3 .   ? 11.17712  -5.96300  40.61144  1.000 31.19583  ? 302 VVO A O1  1 
HETATM 3777 V V1  . VVO D 3 .   ? 11.22220  -4.96641  39.30844  1.000 20.03435  ? 302 VVO A V1  1 
HETATM 3778 C C1  . SIN E 2 .   ? 39.80409  5.55486   10.45164  1.000 64.81601  ? 301 SIN B C1  1 
HETATM 3779 O O1  . SIN E 2 .   ? 40.52329  6.23834   11.22009  1.000 62.56601  ? 301 SIN B O1  1 
HETATM 3780 O O2  . SIN E 2 .   ? 38.58839  5.84941   10.25148  1.000 53.65488  ? 301 SIN B O2  1 
HETATM 3781 C C2  . SIN E 2 .   ? 40.35778  4.34503   9.75419   1.000 40.54039  ? 301 SIN B C2  1 
HETATM 3782 C C3  . SIN E 2 .   ? 39.05470  3.61636   9.49692   1.000 49.64969  ? 301 SIN B C3  1 
HETATM 3783 C C4  . SIN E 2 .   ? 39.34043  2.27648   8.91094   1.000 46.61649  ? 301 SIN B C4  1 
HETATM 3784 O O3  . SIN E 2 .   ? 38.44318  1.73493   8.22650   1.000 47.44601  ? 301 SIN B O3  1 
HETATM 3785 O O4  . SIN E 2 .   ? 40.45703  1.72263   9.09706   1.000 44.47499  ? 301 SIN B O4  1 
HETATM 3786 O O1  . VVO F 3 .   ? 35.53336  6.91218   8.09759   1.000 41.71931  ? 302 VVO B O1  1 
HETATM 3787 V V1  . VVO F 3 .   ? 35.96155  8.17863   7.19515   1.000 28.82318  ? 302 VVO B V1  1 
HETATM 3788 O O   . HOH G 4 .   ? 2.94730   -4.59577  27.99928  1.000 55.64381  ? 401 HOH A O   1 
HETATM 3789 O O   . HOH G 4 .   ? 19.25451  13.19982  49.21869  1.000 52.43054  ? 402 HOH A O   1 
HETATM 3790 O O   . HOH G 4 .   ? 14.01600  17.39017  38.63534  1.000 36.49255  ? 403 HOH A O   1 
HETATM 3791 O O   . HOH G 4 .   ? 6.73756   18.36259  44.42445  1.000 53.43101  ? 404 HOH A O   1 
HETATM 3792 O O   . HOH G 4 .   ? 30.62996  -15.81262 38.99127  1.000 46.60998  ? 405 HOH A O   1 
HETATM 3793 O O   . HOH G 4 .   ? -7.02862  1.63326   48.98461  1.000 30.05548  ? 406 HOH A O   1 
HETATM 3794 O O   . HOH G 4 .   ? -1.04685  12.61071  57.86821  1.000 30.10951  ? 407 HOH A O   1 
HETATM 3795 O O   . HOH G 4 .   ? 23.08894  15.08563  35.57722  1.000 45.16301  ? 408 HOH A O   1 
HETATM 3796 O O   . HOH G 4 .   ? 15.28159  -9.93311  31.30211  1.000 62.95103  ? 409 HOH A O   1 
HETATM 3797 O O   . HOH G 4 .   ? 11.15102  -13.05801 34.01961  1.000 43.04912  ? 410 HOH A O   1 
HETATM 3798 O O   . HOH G 4 .   ? 2.030     -5.659    69.405    1.000 58.51743  ? 411 HOH A O   1 
HETATM 3799 O O   . HOH G 4 .   ? 15.81304  -1.11121  37.52334  1.000 40.97970  ? 412 HOH A O   1 
HETATM 3800 O O   . HOH G 4 .   ? 12.74499  16.67643  49.02134  1.000 47.10439  ? 413 HOH A O   1 
HETATM 3801 O O   . HOH G 4 .   ? 11.98678  -3.46343  41.01725  1.000 22.74745  ? 414 HOH A O   1 
HETATM 3802 O O   . HOH G 4 .   ? -5.72489  -1.62063  47.15981  1.000 48.17678  ? 415 HOH A O   1 
HETATM 3803 O O   . HOH G 4 .   ? -7.83825  -12.87376 53.05828  1.000 39.07997  ? 416 HOH A O   1 
HETATM 3804 O O   . HOH G 4 .   ? 29.08656  -2.66212  52.30445  1.000 36.39246  ? 417 HOH A O   1 
HETATM 3805 O O   . HOH G 4 .   ? 4.15337   9.03738   34.10269  1.000 22.64588  ? 418 HOH A O   1 
HETATM 3806 O O   . HOH G 4 .   ? 17.99288  -4.64991  57.10643  1.000 17.73045  ? 419 HOH A O   1 
HETATM 3807 O O   . HOH G 4 .   ? 0.76367   -8.83143  46.19969  1.000 37.90623  ? 420 HOH A O   1 
HETATM 3808 O O   . HOH G 4 .   ? -3.02570  2.73431   43.16576  1.000 27.16750  ? 421 HOH A O   1 
HETATM 3809 O O   . HOH G 4 .   ? 30.85082  6.17446   37.42107  1.000 39.81871  ? 422 HOH A O   1 
HETATM 3810 O O   . HOH G 4 .   ? 38.05982  -15.94719 45.96601  1.000 43.78276  ? 423 HOH A O   1 
HETATM 3811 O O   . HOH G 4 .   ? 26.52039  -1.70147  50.40074  1.000 24.26120  ? 424 HOH A O   1 
HETATM 3812 O O   . HOH G 4 .   ? -0.98987  -25.20549 56.42509  1.000 34.11958  ? 425 HOH A O   1 
HETATM 3813 O O   . HOH G 4 .   ? 17.52310  -9.63951  55.77911  1.000 23.46034  ? 426 HOH A O   1 
HETATM 3814 O O   . HOH G 4 .   ? 15.58801  19.05848  39.80108  1.000 42.17787  ? 427 HOH A O   1 
HETATM 3815 O O   . HOH G 4 .   ? 21.85634  13.55605  44.71476  1.000 47.73109  ? 428 HOH A O   1 
HETATM 3816 O O   . HOH G 4 .   ? 12.98372  15.82331  46.00553  1.000 29.88744  ? 429 HOH A O   1 
HETATM 3817 O O   . HOH G 4 .   ? 20.41981  -5.48880  23.93494  1.000 38.22604  ? 430 HOH A O   1 
HETATM 3818 O O   . HOH G 4 .   ? -9.45063  14.02941  42.98046  1.000 27.47410  ? 431 HOH A O   1 
HETATM 3819 O O   . HOH G 4 .   ? 3.89505   -1.37709  33.05297  1.000 18.57784  ? 432 HOH A O   1 
HETATM 3820 O O   . HOH G 4 .   ? -2.03361  -9.39191  47.17378  1.000 42.09666  ? 433 HOH A O   1 
HETATM 3821 O O   . HOH G 4 .   ? 0.52928   -6.45928  34.81183  1.000 38.73420  ? 434 HOH A O   1 
HETATM 3822 O O   . HOH G 4 .   ? 6.16059   -3.81007  57.10828  1.000 15.75015  ? 435 HOH A O   1 
HETATM 3823 O O   . HOH G 4 .   ? 1.75562   1.06702   61.26555  1.000 20.79723  ? 436 HOH A O   1 
HETATM 3824 O O   . HOH G 4 .   ? 6.32403   -5.12470  43.87634  1.000 32.94650  ? 437 HOH A O   1 
HETATM 3825 O O   . HOH G 4 .   ? -1.20866  1.24522   57.74460  1.000 21.84763  ? 438 HOH A O   1 
HETATM 3826 O O   . HOH G 4 .   ? 22.04002  -0.42789  36.40729  1.000 16.87261  ? 439 HOH A O   1 
HETATM 3827 O O   . HOH G 4 .   ? 29.11333  1.88371   54.03921  1.000 21.22930  ? 440 HOH A O   1 
HETATM 3828 O O   . HOH G 4 .   ? 24.87395  0.99148   59.73140  1.000 29.50223  ? 441 HOH A O   1 
HETATM 3829 O O   . HOH G 4 .   ? 7.31305   -0.53640  21.50531  1.000 45.21338  ? 442 HOH A O   1 
HETATM 3830 O O   . HOH G 4 .   ? 24.38344  -1.50032  38.24944  1.000 27.54205  ? 443 HOH A O   1 
HETATM 3831 O O   . HOH G 4 .   ? 26.71387  -10.81037 54.55808  1.000 18.60299  ? 444 HOH A O   1 
HETATM 3832 O O   . HOH G 4 .   ? 28.44913  8.34962   48.40044  1.000 45.60533  ? 445 HOH A O   1 
HETATM 3833 O O   . HOH G 4 .   ? -4.91135  13.37382  54.93863  1.000 32.93423  ? 446 HOH A O   1 
HETATM 3834 O O   . HOH G 4 .   ? 10.94219  -19.93141 53.16379  1.000 31.00926  ? 447 HOH A O   1 
HETATM 3835 O O   . HOH G 4 .   ? 15.27471  -12.21594 53.78255  1.000 23.87127  ? 448 HOH A O   1 
HETATM 3836 O O   . HOH G 4 .   ? 11.29332  -4.03443  60.72095  1.000 20.87951  ? 449 HOH A O   1 
HETATM 3837 O O   . HOH G 4 .   ? 25.65153  9.77478   61.80912  1.000 42.64567  ? 450 HOH A O   1 
HETATM 3838 O O   . HOH G 4 .   ? 15.96902  13.07039  37.52657  1.000 22.94042  ? 451 HOH A O   1 
HETATM 3839 O O   . HOH G 4 .   ? 21.75260  6.18293   61.49367  1.000 26.69455  ? 452 HOH A O   1 
HETATM 3840 O O   . HOH G 4 .   ? 7.06278   13.94777  49.81515  1.000 18.89746  ? 453 HOH A O   1 
HETATM 3841 O O   . HOH G 4 .   ? 16.87228  11.52362  33.11129  1.000 22.11595  ? 454 HOH A O   1 
HETATM 3842 O O   . HOH G 4 .   ? 12.12785  13.93161  27.83433  1.000 37.73051  ? 455 HOH A O   1 
HETATM 3843 O O   . HOH G 4 .   ? 21.19278  3.70576   62.20477  1.000 24.57710  ? 456 HOH A O   1 
HETATM 3844 O O   . HOH G 4 .   ? 3.22301   -8.53424  37.05284  1.000 44.56967  ? 457 HOH A O   1 
HETATM 3845 O O   . HOH G 4 .   ? 15.39226  -8.51827  35.60407  1.000 35.91414  ? 458 HOH A O   1 
HETATM 3846 O O   . HOH G 4 .   ? 8.23047   -7.29425  57.03020  1.000 28.93839  ? 459 HOH A O   1 
HETATM 3847 O O   . HOH G 4 .   ? 29.53416  -4.11108  32.05328  1.000 33.09776  ? 460 HOH A O   1 
HETATM 3848 O O   . HOH G 4 .   ? 3.30937   -11.98887 53.81414  1.000 23.86827  ? 461 HOH A O   1 
HETATM 3849 O O   . HOH G 4 .   ? 18.58544  -3.39904  69.41298  1.000 44.12553  ? 462 HOH A O   1 
HETATM 3850 O O   . HOH G 4 .   ? 5.04088   1.68044   26.32079  1.000 50.77186  ? 463 HOH A O   1 
HETATM 3851 O O   . HOH G 4 .   ? 24.40493  -9.44457  53.74362  1.000 20.46261  ? 464 HOH A O   1 
HETATM 3852 O O   . HOH G 4 .   ? 21.05654  10.66071  43.26137  1.000 32.55225  ? 465 HOH A O   1 
HETATM 3853 O O   . HOH G 4 .   ? -1.08818  -10.44270 60.98609  1.000 32.73418  ? 466 HOH A O   1 
HETATM 3854 O O   . HOH G 4 .   ? 28.66417  8.73778   45.32550  1.000 31.69986  ? 467 HOH A O   1 
HETATM 3855 O O   . HOH G 4 .   ? 35.20081  -3.24084  43.14214  1.000 28.54527  ? 468 HOH A O   1 
HETATM 3856 O O   . HOH G 4 .   ? 17.14409  -7.30730  57.70703  1.000 21.37164  ? 469 HOH A O   1 
HETATM 3857 O O   . HOH G 4 .   ? 23.61589  6.27414   36.42647  1.000 25.34545  ? 470 HOH A O   1 
HETATM 3858 O O   . HOH G 4 .   ? 34.23836  -9.55678  45.97398  1.000 42.20840  ? 471 HOH A O   1 
HETATM 3859 O O   . HOH G 4 .   ? 30.61900  0.57813   39.96046  1.000 35.95136  ? 472 HOH A O   1 
HETATM 3860 O O   . HOH G 4 .   ? 7.76995   -1.09686  35.34016  1.000 16.82310  ? 473 HOH A O   1 
HETATM 3861 O O   . HOH G 4 .   ? 4.09405   -5.40427  56.37627  1.000 25.49186  ? 474 HOH A O   1 
HETATM 3862 O O   . HOH G 4 .   ? 13.97096  6.34561   59.27694  1.000 19.82740  ? 475 HOH A O   1 
HETATM 3863 O O   . HOH G 4 .   ? 17.59575  -5.37286  63.85007  1.000 27.38445  ? 476 HOH A O   1 
HETATM 3864 O O   . HOH G 4 .   ? 17.20718  8.75894   64.21730  1.000 34.62601  ? 477 HOH A O   1 
HETATM 3865 O O   . HOH G 4 .   ? 1.74126   -6.64326  54.20666  1.000 31.20332  ? 478 HOH A O   1 
HETATM 3866 O O   . HOH G 4 .   ? 26.98607  5.24780   34.71433  1.000 22.05196  ? 479 HOH A O   1 
HETATM 3867 O O   . HOH G 4 .   ? 14.59874  4.06609   21.95735  1.000 24.53116  ? 480 HOH A O   1 
HETATM 3868 O O   . HOH G 4 .   ? 4.94461   14.07412  43.52602  1.000 24.68692  ? 481 HOH A O   1 
HETATM 3869 O O   . HOH G 4 .   ? -2.65885  -4.00509  52.11880  1.000 42.40189  ? 482 HOH A O   1 
HETATM 3870 O O   . HOH G 4 .   ? -9.19709  16.79028  40.07090  1.000 49.36826  ? 483 HOH A O   1 
HETATM 3871 O O   . HOH G 4 .   ? -3.20406  -4.61811  60.91422  1.000 33.04945  ? 484 HOH A O   1 
HETATM 3872 O O   . HOH G 4 .   ? -0.10747  2.52333   59.95032  1.000 20.41114  ? 485 HOH A O   1 
HETATM 3873 O O   . HOH G 4 .   ? 12.78979  -7.13509  49.31292  1.000 27.48886  ? 486 HOH A O   1 
HETATM 3874 O O   . HOH G 4 .   ? -5.46447  4.86314   42.76950  1.000 28.32117  ? 487 HOH A O   1 
HETATM 3875 O O   . HOH G 4 .   ? 8.99680   -0.82854  43.33534  1.000 20.56968  ? 488 HOH A O   1 
HETATM 3876 O O   . HOH G 4 .   ? 5.92351   14.24880  52.31506  1.000 22.38201  ? 489 HOH A O   1 
HETATM 3877 O O   . HOH G 4 .   ? 30.50073  5.28373   44.44173  1.000 30.81566  ? 490 HOH A O   1 
HETATM 3878 O O   . HOH G 4 .   ? 3.47827   -0.39956  47.27836  1.000 18.93546  ? 491 HOH A O   1 
HETATM 3879 O O   . HOH G 4 .   ? -7.23563  -20.45351 54.42484  1.000 33.22351  ? 492 HOH A O   1 
HETATM 3880 O O   . HOH G 4 .   ? -8.13487  12.93743  49.20259  1.000 32.49785  ? 493 HOH A O   1 
HETATM 3881 O O   . HOH G 4 .   ? 8.16447   -10.05178 55.90342  1.000 48.63872  ? 494 HOH A O   1 
HETATM 3882 O O   . HOH G 4 .   ? 22.59956  -9.61227  29.61441  1.000 40.81350  ? 495 HOH A O   1 
HETATM 3883 O O   . HOH G 4 .   ? 26.67559  -11.03853 51.64613  1.000 25.26551  ? 496 HOH A O   1 
HETATM 3884 O O   . HOH G 4 .   ? 5.02357   7.45482   62.76687  1.000 26.82691  ? 497 HOH A O   1 
HETATM 3885 O O   . HOH G 4 .   ? 6.753     16.156    57.644    1.000 27.91238  ? 498 HOH A O   1 
HETATM 3886 O O   . HOH G 4 .   ? -8.21957  -15.35407 52.39132  1.000 33.59030  ? 499 HOH A O   1 
HETATM 3887 O O   . HOH G 4 .   ? 3.493     17.768    58.892    1.000 34.98847  ? 500 HOH A O   1 
HETATM 3888 O O   . HOH G 4 .   ? 2.48512   9.03491   62.94738  1.000 31.07750  ? 501 HOH A O   1 
HETATM 3889 O O   . HOH G 4 .   ? -1.41592  -8.34545  57.59877  1.000 41.66630  ? 502 HOH A O   1 
HETATM 3890 O O   . HOH G 4 .   ? 31.26466  12.60271  56.29364  1.000 41.58439  ? 503 HOH A O   1 
HETATM 3891 O O   . HOH G 4 .   ? 5.17250   -6.49884  45.70502  1.000 33.09499  ? 504 HOH A O   1 
HETATM 3892 O O   . HOH G 4 .   ? 15.26082  -8.61520  60.57771  1.000 31.29317  ? 505 HOH A O   1 
HETATM 3893 O O   . HOH G 4 .   ? 20.78332  -5.85562  42.29100  1.000 38.81990  ? 506 HOH A O   1 
HETATM 3894 O O   . HOH G 4 .   ? 14.03349  -3.97870  63.29369  1.000 37.42589  ? 507 HOH A O   1 
HETATM 3895 O O   . HOH G 4 .   ? -0.31746  -3.46749  33.60699  1.000 38.82121  ? 508 HOH A O   1 
HETATM 3896 O O   . HOH G 4 .   ? 20.73051  -5.03421  57.82237  1.000 18.75195  ? 509 HOH A O   1 
HETATM 3897 O O   . HOH G 4 .   ? 5.21140   -7.95187  55.84712  1.000 28.77531  ? 510 HOH A O   1 
HETATM 3898 O O   . HOH G 4 .   ? 2.35074   4.61935   36.63503  1.000 28.18510  ? 511 HOH A O   1 
HETATM 3899 O O   . HOH G 4 .   ? -0.41208  -0.16460  32.51746  1.000 41.05949  ? 512 HOH A O   1 
HETATM 3900 O O   . HOH G 4 .   ? -0.35500  -1.64892  48.54084  1.000 53.41526  ? 513 HOH A O   1 
HETATM 3901 O O   . HOH G 4 .   ? -3.85859  15.45383  54.56772  1.000 32.60977  ? 514 HOH A O   1 
HETATM 3902 O O   . HOH G 4 .   ? 3.27717   -4.65836  44.58237  1.000 25.86741  ? 515 HOH A O   1 
HETATM 3903 O O   . HOH G 4 .   ? 37.85231  -5.76847  41.04142  1.000 39.68711  ? 516 HOH A O   1 
HETATM 3904 O O   . HOH G 4 .   ? 14.60064  12.13630  58.15740  1.000 26.27890  ? 517 HOH A O   1 
HETATM 3905 O O   . HOH G 4 .   ? 13.96683  10.53116  30.66418  1.000 26.83162  ? 518 HOH A O   1 
HETATM 3906 O O   . HOH G 4 .   ? 40.39003  -14.95949 44.74868  1.000 35.65097  ? 519 HOH A O   1 
HETATM 3907 O O   . HOH G 4 .   ? 9.47699   -8.70107  55.94049  1.000 33.00187  ? 520 HOH A O   1 
HETATM 3908 O O   . HOH G 4 .   ? 32.46332  -2.82721  40.32580  1.000 30.94743  ? 521 HOH A O   1 
HETATM 3909 O O   . HOH G 4 .   ? 16.04185  11.85354  45.93685  1.000 37.34043  ? 522 HOH A O   1 
HETATM 3910 O O   . HOH G 4 .   ? -1.51424  -2.86982  48.87719  1.000 43.02365  ? 523 HOH A O   1 
HETATM 3911 O O   . HOH G 4 .   ? 9.89393   -17.34702 49.46298  1.000 37.55256  ? 524 HOH A O   1 
HETATM 3912 O O   . HOH G 4 .   ? 2.06804   -23.43340 56.00701  1.000 33.41215  ? 525 HOH A O   1 
HETATM 3913 O O   . HOH G 4 .   ? 21.49447  2.43835   58.78157  1.000 21.92512  ? 526 HOH A O   1 
HETATM 3914 O O   . HOH G 4 .   ? -8.53333  15.63380  41.95717  1.000 44.48609  ? 527 HOH A O   1 
HETATM 3915 O O   . HOH G 4 .   ? 3.16471   16.17300  44.30499  1.000 40.59787  ? 528 HOH A O   1 
HETATM 3916 O O   . HOH G 4 .   ? 33.24597  -2.68937  36.24695  1.000 36.20122  ? 529 HOH A O   1 
HETATM 3917 O O   . HOH G 4 .   ? 20.31503  -3.35501  63.57352  1.000 30.31469  ? 530 HOH A O   1 
HETATM 3918 O O   . HOH G 4 .   ? 7.41094   -4.52495  60.44787  1.000 27.95970  ? 531 HOH A O   1 
HETATM 3919 O O   . HOH G 4 .   ? 2.11808   10.43470  30.31863  1.000 49.90577  ? 532 HOH A O   1 
HETATM 3920 O O   . HOH G 4 .   ? 34.80352  -13.81990 46.72264  1.000 47.08107  ? 533 HOH A O   1 
HETATM 3921 O O   . HOH G 4 .   ? 21.90359  -8.26846  38.29074  1.000 31.54062  ? 534 HOH A O   1 
HETATM 3922 O O   . HOH G 4 .   ? 33.41457  -12.87784 34.67099  1.000 45.50329  ? 535 HOH A O   1 
HETATM 3923 O O   . HOH G 4 .   ? 28.30611  0.30459   49.83962  1.000 32.08420  ? 536 HOH A O   1 
HETATM 3924 O O   . HOH G 4 .   ? 3.18088   3.66863   27.95831  1.000 39.68319  ? 537 HOH A O   1 
HETATM 3925 O O   . HOH G 4 .   ? 7.78905   -2.46568  45.33370  1.000 22.78314  ? 538 HOH A O   1 
HETATM 3926 O O   . HOH G 4 .   ? 15.51569  15.36084  41.33719  1.000 44.19543  ? 539 HOH A O   1 
HETATM 3927 O O   . HOH G 4 .   ? 23.21012  -11.24719 38.44602  1.000 34.10115  ? 540 HOH A O   1 
HETATM 3928 O O   . HOH G 4 .   ? 30.09810  1.11265   45.25880  1.000 33.33055  ? 541 HOH A O   1 
HETATM 3929 O O   . HOH G 4 .   ? 3.22530   -2.84920  64.71045  1.000 34.20136  ? 542 HOH A O   1 
HETATM 3930 O O   . HOH G 4 .   ? -7.51779  16.66890  42.80093  1.000 35.28144  ? 543 HOH A O   1 
HETATM 3931 O O   . HOH G 4 .   ? 13.88984  -5.12834  22.09310  1.000 38.38713  ? 544 HOH A O   1 
HETATM 3932 O O   . HOH G 4 .   ? 21.55961  7.70303   37.67644  1.000 18.08654  ? 545 HOH A O   1 
HETATM 3933 O O   . HOH G 4 .   ? 30.58777  2.43557   43.27412  1.000 32.73058  ? 546 HOH A O   1 
HETATM 3934 O O   . HOH G 4 .   ? 13.03114  14.04392  56.20920  1.000 41.25704  ? 547 HOH A O   1 
HETATM 3935 O O   . HOH G 4 .   ? 0.30882   -4.96570  57.43284  1.000 32.86013  ? 548 HOH A O   1 
HETATM 3936 O O   . HOH G 4 .   ? 4.98137   -1.69469  63.22844  1.000 26.14380  ? 549 HOH A O   1 
HETATM 3937 O O   . HOH G 4 .   ? -5.506    12.176    60.495    1.000 50.85116  ? 550 HOH A O   1 
HETATM 3938 O O   . HOH G 4 .   ? 25.36198  11.65720  60.31354  1.000 49.95445  ? 551 HOH A O   1 
HETATM 3939 O O   . HOH G 4 .   ? 21.89179  -3.55152  24.74299  1.000 38.10781  ? 552 HOH A O   1 
HETATM 3940 O O   . HOH G 4 .   ? -2.69566  -11.89602 47.00153  1.000 34.54019  ? 553 HOH A O   1 
HETATM 3941 O O   . HOH G 4 .   ? 29.50219  2.81909   51.72154  1.000 32.35380  ? 554 HOH A O   1 
HETATM 3942 O O   . HOH G 4 .   ? -6.36007  -12.26883 54.72601  1.000 44.65064  ? 555 HOH A O   1 
HETATM 3943 O O   . HOH G 4 .   ? -0.81378  -0.33454  40.98320  1.000 43.76667  ? 556 HOH A O   1 
HETATM 3944 O O   . HOH G 4 .   ? -2.589    -5.915    68.880    1.000 45.23106  ? 557 HOH A O   1 
HETATM 3945 O O   . HOH G 4 .   ? -3.20604  -9.48627  59.15971  1.000 40.73428  ? 558 HOH A O   1 
HETATM 3946 O O   . HOH G 4 .   ? -0.24967  1.99604   37.56818  1.000 41.16356  ? 559 HOH A O   1 
HETATM 3947 O O   . HOH G 4 .   ? 4.84726   -7.77299  34.83975  1.000 28.24777  ? 560 HOH A O   1 
HETATM 3948 O O   . HOH G 4 .   ? 2.78957   16.40737  40.47655  1.000 44.02735  ? 561 HOH A O   1 
HETATM 3949 O O   . HOH G 4 .   ? 7.66457   -12.26747 54.23294  1.000 44.99252  ? 562 HOH A O   1 
HETATM 3950 O O   . HOH G 4 .   ? 12.90966  14.51193  52.49737  1.000 34.21891  ? 563 HOH A O   1 
HETATM 3951 O O   . HOH G 4 .   ? -0.01569  -8.41149  60.70475  1.000 30.91277  ? 564 HOH A O   1 
HETATM 3952 O O   . HOH G 4 .   ? 21.09005  14.25660  35.07808  1.000 45.58102  ? 565 HOH A O   1 
HETATM 3953 O O   . HOH G 4 .   ? 15.20538  13.96023  44.93245  1.000 46.10837  ? 566 HOH A O   1 
HETATM 3954 O O   . HOH G 4 .   ? 29.82855  -2.71577  33.48030  1.000 38.03318  ? 567 HOH A O   1 
HETATM 3955 O O   . HOH G 4 .   ? 4.880     0.171     69.981    1.000 50.38009  ? 568 HOH A O   1 
HETATM 3956 O O   . HOH G 4 .   ? 20.67848  -7.10246  40.44621  1.000 41.18359  ? 569 HOH A O   1 
HETATM 3957 O O   . HOH G 4 .   ? 21.13111  -6.69742  60.29325  1.000 38.00057  ? 570 HOH A O   1 
HETATM 3958 O O   . HOH G 4 .   ? 19.34934  12.33375  33.26122  1.000 36.72415  ? 571 HOH A O   1 
HETATM 3959 O O   . HOH G 4 .   ? -10.43691 9.68302   49.24127  1.000 45.32575  ? 572 HOH A O   1 
HETATM 3960 O O   . HOH G 4 .   ? 5.037     18.586    57.909    1.000 29.62032  ? 573 HOH A O   1 
HETATM 3961 O O   . HOH G 4 .   ? 31.47110  -6.57354  50.33139  1.000 40.33629  ? 574 HOH A O   1 
HETATM 3962 O O   . HOH G 4 .   ? -5.52963  17.17185  37.87886  1.000 45.76600  ? 575 HOH A O   1 
HETATM 3963 O O   . HOH G 4 .   ? -2.22212  -2.42784  50.96075  1.000 42.56413  ? 576 HOH A O   1 
HETATM 3964 O O   . HOH G 4 .   ? 5.76091   -9.66339  54.26991  1.000 33.30050  ? 577 HOH A O   1 
HETATM 3965 O O   . HOH G 4 .   ? 5.80469   -9.73207  33.28878  1.000 41.91340  ? 578 HOH A O   1 
HETATM 3966 O O   . HOH G 4 .   ? 18.63481  -8.79932  59.36351  1.000 37.99989  ? 579 HOH A O   1 
HETATM 3967 O O   . HOH G 4 .   ? -6.82503  9.74562   37.83647  1.000 36.20064  ? 580 HOH A O   1 
HETATM 3968 O O   . HOH G 4 .   ? -4.05561  11.89767  57.26537  1.000 31.99841  ? 581 HOH A O   1 
HETATM 3969 O O   . HOH G 4 .   ? 0.804     -7.439    66.509    1.000 44.32012  ? 582 HOH A O   1 
HETATM 3970 O O   . HOH G 4 .   ? 16.20252  -2.33198  20.66901  1.000 44.39096  ? 583 HOH A O   1 
HETATM 3971 O O   . HOH G 4 .   ? 28.11014  -1.34656  33.28316  1.000 44.43690  ? 584 HOH A O   1 
HETATM 3972 O O   . HOH G 4 .   ? 0.57385   5.72104   37.91865  1.000 53.67643  ? 585 HOH A O   1 
HETATM 3973 O O   . HOH G 4 .   ? 15.00430  -7.79384  37.11164  1.000 46.17592  ? 586 HOH A O   1 
HETATM 3974 O O   . HOH G 4 .   ? 2.14889   9.84205   34.40988  1.000 50.24986  ? 587 HOH A O   1 
HETATM 3975 O O   . HOH G 4 .   ? 8.819     16.475    55.729    1.000 36.84135  ? 588 HOH A O   1 
HETATM 3976 O O   . HOH G 4 .   ? 9.58582   -20.10390 50.68492  1.000 52.12617  ? 589 HOH A O   1 
HETATM 3977 O O   . HOH G 4 .   ? 15.68182  15.13162  39.27849  1.000 54.52589  ? 590 HOH A O   1 
HETATM 3978 O O   . HOH G 4 .   ? 17.78665  12.92083  47.25751  1.000 56.67493  ? 591 HOH A O   1 
HETATM 3979 O O   . HOH G 4 .   ? 14.29454  -1.06167  38.92510  1.000 44.94691  ? 592 HOH A O   1 
HETATM 3980 O O   . HOH G 4 .   ? 1.782     19.129    57.440    1.000 27.44947  ? 593 HOH A O   1 
HETATM 3981 O O   . HOH G 4 .   ? 29.64974  -1.01413  54.28106  1.000 32.75087  ? 594 HOH A O   1 
HETATM 3982 O O   . HOH G 4 .   ? 6.94799   16.26667  53.84351  1.000 31.97167  ? 595 HOH A O   1 
HETATM 3983 O O   . HOH G 4 .   ? 8.092     0.721     65.033    1.000 41.60788  ? 596 HOH A O   1 
HETATM 3984 O O   . HOH G 4 .   ? -6.90103  9.89356   35.56778  1.000 54.20290  ? 597 HOH A O   1 
HETATM 3985 O O   . HOH G 4 .   ? 5.28042   -22.11136 47.74127  1.000 52.95573  ? 598 HOH A O   1 
HETATM 3986 O O   . HOH G 4 .   ? 24.23258  2.83973   61.93181  1.000 46.38166  ? 599 HOH A O   1 
HETATM 3987 O O   . HOH G 4 .   ? 6.56243   -23.00762 49.30060  1.000 51.30092  ? 600 HOH A O   1 
HETATM 3988 O O   . HOH G 4 .   ? -8.28594  -16.47772 54.85543  1.000 33.96961  ? 601 HOH A O   1 
HETATM 3989 O O   . HOH G 4 .   ? 1.81501   -2.87628  31.99518  1.000 34.27355  ? 602 HOH A O   1 
HETATM 3990 O O   . HOH G 4 .   ? -7.72120  3.83356   43.68569  1.000 42.92624  ? 603 HOH A O   1 
HETATM 3991 O O   . HOH G 4 .   ? 13.748    16.044    58.472    1.000 36.36285  ? 604 HOH A O   1 
HETATM 3992 O O   . HOH G 4 .   ? 18.21539  -1.08254  20.99376  1.000 42.27745  ? 605 HOH A O   1 
HETATM 3993 O O   . HOH G 4 .   ? 21.68710  7.74928   63.87550  1.000 40.81424  ? 606 HOH A O   1 
HETATM 3994 O O   . HOH G 4 .   ? 23.13573  6.95476   64.68338  1.000 57.48574  ? 607 HOH A O   1 
HETATM 3995 O O   . HOH G 4 .   ? 20.825    -0.139    67.765    1.000 39.48947  ? 608 HOH A O   1 
HETATM 3996 O O   . HOH G 4 .   ? 14.52942  -2.11863  18.59814  1.000 51.42686  ? 609 HOH A O   1 
HETATM 3997 O O   . HOH G 4 .   ? 21.04571  3.55800   64.87668  1.000 25.80065  ? 610 HOH A O   1 
HETATM 3998 O O   . HOH G 4 .   ? 1.28844   6.09606   35.63509  1.000 48.40885  ? 611 HOH A O   1 
HETATM 3999 O O   . HOH G 4 .   ? 34.73832  -7.20432  46.61860  1.000 52.53310  ? 612 HOH A O   1 
HETATM 4000 O O   . HOH G 4 .   ? 8.29786   13.16743  24.16378  1.000 46.68706  ? 613 HOH A O   1 
HETATM 4001 O O   . HOH G 4 .   ? 16.25748  16.13701  43.90482  1.000 59.12269  ? 614 HOH A O   1 
HETATM 4002 O O   . HOH G 4 .   ? 35.34900  -5.24945  46.91230  1.000 45.69856  ? 615 HOH A O   1 
HETATM 4003 O O   . HOH G 4 .   ? 2.92985   -6.48129  32.82801  1.000 40.15147  ? 616 HOH A O   1 
HETATM 4004 O O   . HOH G 4 .   ? -5.45484  7.93888   36.83943  1.000 48.02935  ? 617 HOH A O   1 
HETATM 4005 O O   . HOH H 4 .   ? 32.62085  8.43109   30.74312  1.000 41.75955  ? 401 HOH B O   1 
HETATM 4006 O O   . HOH H 4 .   ? 49.07938  13.28491  26.88523  1.000 63.83520  ? 402 HOH B O   1 
HETATM 4007 O O   . HOH H 4 .   ? 45.50694  8.37525   1.67829   1.000 54.16719  ? 403 HOH B O   1 
HETATM 4008 O O   . HOH H 4 .   ? 47.87459  -0.39008  0.08086   1.000 35.65672  ? 404 HOH B O   1 
HETATM 4009 O O   . HOH H 4 .   ? 38.52022  -4.70711  -7.03000  1.000 44.65518  ? 405 HOH B O   1 
HETATM 4010 O O   . HOH H 4 .   ? 31.52935  10.63830  35.15944  1.000 47.45280  ? 406 HOH B O   1 
HETATM 4011 O O   . HOH H 4 .   ? 26.74283  -10.93955 29.61435  1.000 43.34708  ? 407 HOH B O   1 
HETATM 4012 O O   . HOH H 4 .   ? 34.08676  16.34467  5.91130   1.000 43.20155  ? 408 HOH B O   1 
HETATM 4013 O O   . HOH H 4 .   ? 27.25648  5.72361   5.57169   1.000 48.54874  ? 409 HOH B O   1 
HETATM 4014 O O   . HOH H 4 .   ? 21.00778  3.72761   6.60592   1.000 43.66128  ? 410 HOH B O   1 
HETATM 4015 O O   . HOH H 4 .   ? 34.10759  -0.84619  -1.43448  1.000 41.82617  ? 411 HOH B O   1 
HETATM 4016 O O   . HOH H 4 .   ? 36.57849  1.61104   6.89272   1.000 40.14212  ? 412 HOH B O   1 
HETATM 4017 O O   . HOH H 4 .   ? 42.07029  15.42870  20.54904  1.000 41.57705  ? 413 HOH B O   1 
HETATM 4018 O O   . HOH H 4 .   ? 27.08646  -7.05850  -2.19208  1.000 49.54288  ? 414 HOH B O   1 
HETATM 4019 O O   . HOH H 4 .   ? 21.65622  -4.18462  5.76123   1.000 38.63512  ? 415 HOH B O   1 
HETATM 4020 O O   . HOH H 4 .   ? 24.81983  -13.17385 15.12908  1.000 35.83829  ? 416 HOH B O   1 
HETATM 4021 O O   . HOH H 4 .   ? 24.07031  11.89404  13.31864  1.000 36.98826  ? 417 HOH B O   1 
HETATM 4022 O O   . HOH H 4 .   ? 36.77146  25.86529  29.73725  1.000 53.27676  ? 418 HOH B O   1 
HETATM 4023 O O   . HOH H 4 .   ? 42.69445  -3.88141  7.85777   1.000 37.47034  ? 419 HOH B O   1 
HETATM 4024 O O   . HOH H 4 .   ? 27.24017  19.13171  34.44902  1.000 43.61025  ? 420 HOH B O   1 
HETATM 4025 O O   . HOH H 4 .   ? 48.47145  -6.10465  12.21798  1.000 38.48150  ? 421 HOH B O   1 
HETATM 4026 O O   . HOH H 4 .   ? 22.83908  -5.64158  11.24853  1.000 24.87517  ? 422 HOH B O   1 
HETATM 4027 O O   . HOH H 4 .   ? 43.65808  -1.20638  8.86602   1.000 30.52669  ? 423 HOH B O   1 
HETATM 4028 O O   . HOH H 4 .   ? 11.09212  7.00395   19.02440  1.000 56.98940  ? 424 HOH B O   1 
HETATM 4029 O O   . HOH H 4 .   ? 45.97955  -7.91105  17.87857  1.000 44.52607  ? 425 HOH B O   1 
HETATM 4030 O O   . HOH H 4 .   ? 20.93446  10.32508  31.43860  1.000 17.83375  ? 426 HOH B O   1 
HETATM 4031 O O   . HOH H 4 .   ? 14.56344  7.27767   20.46100  1.000 28.15580  ? 427 HOH B O   1 
HETATM 4032 O O   . HOH H 4 .   ? 20.45279  11.78746  -1.85525  1.000 30.56256  ? 428 HOH B O   1 
HETATM 4033 O O   . HOH H 4 .   ? 43.10451  2.70611   29.93084  1.000 48.49718  ? 429 HOH B O   1 
HETATM 4034 O O   . HOH H 4 .   ? 18.77797  5.07376   14.26412  1.000 20.54518  ? 430 HOH B O   1 
HETATM 4035 O O   . HOH H 4 .   ? 38.96375  14.35056  29.41776  1.000 49.09817  ? 431 HOH B O   1 
HETATM 4036 O O   . HOH H 4 .   ? 21.44313  -2.58607  21.60713  1.000 49.92274  ? 432 HOH B O   1 
HETATM 4037 O O   . HOH H 4 .   ? 31.18462  5.43033   29.15003  1.000 22.59805  ? 433 HOH B O   1 
HETATM 4038 O O   . HOH H 4 .   ? 15.85245  11.81449  14.56392  1.000 31.80209  ? 434 HOH B O   1 
HETATM 4039 O O   . HOH H 4 .   ? 26.46998  -9.24149  4.29371   1.000 30.00935  ? 435 HOH B O   1 
HETATM 4040 O O   . HOH H 4 .   ? 16.71889  -6.50561  19.16064  1.000 34.55418  ? 436 HOH B O   1 
HETATM 4041 O O   . HOH H 4 .   ? 25.43048  -9.40362  31.99970  1.000 36.03271  ? 437 HOH B O   1 
HETATM 4042 O O   . HOH H 4 .   ? 31.45839  -14.78485 13.76425  1.000 36.69370  ? 438 HOH B O   1 
HETATM 4043 O O   . HOH H 4 .   ? 40.71609  -0.53059  -11.16972 1.000 58.90364  ? 439 HOH B O   1 
HETATM 4044 O O   . HOH H 4 .   ? 47.38089  18.29479  11.84059  1.000 55.30040  ? 440 HOH B O   1 
HETATM 4045 O O   . HOH H 4 .   ? 16.99898  11.14473  20.88675  1.000 19.72110  ? 441 HOH B O   1 
HETATM 4046 O O   . HOH H 4 .   ? 39.79597  16.97526  11.04471  1.000 36.30367  ? 442 HOH B O   1 
HETATM 4047 O O   . HOH H 4 .   ? 44.32433  6.21558   0.53254   1.000 45.06792  ? 443 HOH B O   1 
HETATM 4048 O O   . HOH H 4 .   ? 44.46643  2.81746   28.34785  1.000 40.63113  ? 444 HOH B O   1 
HETATM 4049 O O   . HOH H 4 .   ? 44.83650  2.62137   23.41727  1.000 37.96755  ? 445 HOH B O   1 
HETATM 4050 O O   . HOH H 4 .   ? 29.91274  18.55505  18.69581  1.000 37.64008  ? 446 HOH B O   1 
HETATM 4051 O O   . HOH H 4 .   ? 30.48478  4.87420   3.02282   1.000 44.63831  ? 447 HOH B O   1 
HETATM 4052 O O   . HOH H 4 .   ? 27.88853  -1.08605  29.62358  1.000 29.63370  ? 448 HOH B O   1 
HETATM 4053 O O   . HOH H 4 .   ? 30.50084  6.40633   -2.18466  1.000 53.53875  ? 449 HOH B O   1 
HETATM 4054 O O   . HOH H 4 .   ? 23.04636  20.04859  20.34275  1.000 38.41775  ? 450 HOH B O   1 
HETATM 4055 O O   . HOH H 4 .   ? 35.98917  9.99489   27.99100  1.000 34.11412  ? 451 HOH B O   1 
HETATM 4056 O O   . HOH H 4 .   ? 39.44718  0.21816   2.03144   1.000 37.45943  ? 452 HOH B O   1 
HETATM 4057 O O   . HOH H 4 .   ? 23.86169  -3.78635  23.24931  1.000 29.23967  ? 453 HOH B O   1 
HETATM 4058 O O   . HOH H 4 .   ? 39.42959  12.34912  10.98930  1.000 31.93584  ? 454 HOH B O   1 
HETATM 4059 O O   . HOH H 4 .   ? 11.23104  6.24421   27.05817  1.000 30.49767  ? 455 HOH B O   1 
HETATM 4060 O O   . HOH H 4 .   ? 25.97620  19.62843  31.72567  1.000 39.97895  ? 456 HOH B O   1 
HETATM 4061 O O   . HOH H 4 .   ? 33.11393  21.61083  32.37312  1.000 41.36322  ? 457 HOH B O   1 
HETATM 4062 O O   . HOH H 4 .   ? 32.78510  -10.65482 10.53509  1.000 29.63089  ? 458 HOH B O   1 
HETATM 4063 O O   . HOH H 4 .   ? 37.03266  1.68894   28.50560  1.000 37.57234  ? 459 HOH B O   1 
HETATM 4064 O O   . HOH H 4 .   ? 38.63533  -12.46513 18.91530  1.000 44.74550  ? 460 HOH B O   1 
HETATM 4065 O O   . HOH H 4 .   ? 16.04711  -4.06592  13.20897  1.000 33.06735  ? 461 HOH B O   1 
HETATM 4066 O O   . HOH H 4 .   ? 18.38961  -10.35632 13.23237  1.000 39.50014  ? 462 HOH B O   1 
HETATM 4067 O O   . HOH H 4 .   ? 24.48053  -4.22723  27.18074  1.000 42.87632  ? 463 HOH B O   1 
HETATM 4068 O O   . HOH H 4 .   ? 30.72242  -1.08327  28.93725  1.000 22.61816  ? 464 HOH B O   1 
HETATM 4069 O O   . HOH H 4 .   ? 19.14765  0.94334   24.48311  1.000 27.37144  ? 465 HOH B O   1 
HETATM 4070 O O   . HOH H 4 .   ? 23.03169  -8.13673  10.24690  1.000 31.86535  ? 466 HOH B O   1 
HETATM 4071 O O   . HOH H 4 .   ? 16.27374  1.45483   13.80589  1.000 33.06490  ? 467 HOH B O   1 
HETATM 4072 O O   . HOH H 4 .   ? 41.84147  -14.95727 4.92694   1.000 35.86680  ? 468 HOH B O   1 
HETATM 4073 O O   . HOH H 4 .   ? 12.74272  4.28753   13.17389  1.000 35.95712  ? 469 HOH B O   1 
HETATM 4074 O O   . HOH H 4 .   ? 14.23875  14.54283  27.37484  1.000 47.13223  ? 470 HOH B O   1 
HETATM 4075 O O   . HOH H 4 .   ? 19.36955  6.91560   12.31202  1.000 21.28038  ? 471 HOH B O   1 
HETATM 4076 O O   . HOH H 4 .   ? 18.84138  -4.07234  7.64729   1.000 46.06164  ? 472 HOH B O   1 
HETATM 4077 O O   . HOH H 4 .   ? 10.90109  12.90547  25.09644  1.000 34.65939  ? 473 HOH B O   1 
HETATM 4078 O O   . HOH H 4 .   ? 28.71438  5.45591   30.21071  1.000 18.83329  ? 474 HOH B O   1 
HETATM 4079 O O   . HOH H 4 .   ? 14.83888  3.10292   15.22831  1.000 31.76067  ? 475 HOH B O   1 
HETATM 4080 O O   . HOH H 4 .   ? 21.83443  13.23656  14.25121  1.000 34.99648  ? 476 HOH B O   1 
HETATM 4081 O O   . HOH H 4 .   ? 16.43923  9.81887   31.25520  1.000 33.22252  ? 477 HOH B O   1 
HETATM 4082 O O   . HOH H 4 .   ? 17.17883  1.45458   22.68178  1.000 26.00815  ? 478 HOH B O   1 
HETATM 4083 O O   . HOH H 4 .   ? 35.12389  18.39637  16.09685  1.000 45.35787  ? 479 HOH B O   1 
HETATM 4084 O O   . HOH H 4 .   ? 39.53820  6.29451   2.44235   1.000 44.94685  ? 480 HOH B O   1 
HETATM 4085 O O   . HOH H 4 .   ? 24.95980  -10.10492 17.36490  1.000 28.94764  ? 481 HOH B O   1 
HETATM 4086 O O   . HOH H 4 .   ? 27.44626  11.26701  15.69262  1.000 29.13794  ? 482 HOH B O   1 
HETATM 4087 O O   . HOH H 4 .   ? 15.87065  9.17077   22.10076  1.000 23.24910  ? 483 HOH B O   1 
HETATM 4088 O O   . HOH H 4 .   ? 20.24054  -9.18167  8.99077   1.000 46.46956  ? 484 HOH B O   1 
HETATM 4089 O O   . HOH H 4 .   ? 16.20373  16.51038  19.66845  1.000 44.12953  ? 485 HOH B O   1 
HETATM 4090 O O   . HOH H 4 .   ? 29.98654  7.17475   33.75895  1.000 40.01868  ? 486 HOH B O   1 
HETATM 4091 O O   . HOH H 4 .   ? 17.32878  -1.15218  14.39510  1.000 38.14677  ? 487 HOH B O   1 
HETATM 4092 O O   . HOH H 4 .   ? 34.06912  -14.37968 13.77376  1.000 40.18909  ? 488 HOH B O   1 
HETATM 4093 O O   . HOH H 4 .   ? 30.21980  21.14694  21.61219  1.000 36.61777  ? 489 HOH B O   1 
HETATM 4094 O O   . HOH H 4 .   ? 36.20957  15.76675  5.00544   1.000 46.01431  ? 490 HOH B O   1 
HETATM 4095 O O   . HOH H 4 .   ? 42.89365  -1.63046  -14.12671 1.000 54.60444  ? 491 HOH B O   1 
HETATM 4096 O O   . HOH H 4 .   ? 16.43173  -7.81216  11.80087  1.000 38.52760  ? 492 HOH B O   1 
HETATM 4097 O O   . HOH H 4 .   ? 23.89837  15.03915  15.55580  1.000 42.57412  ? 493 HOH B O   1 
HETATM 4098 O O   . HOH H 4 .   ? 28.01266  21.90854  29.22306  1.000 45.91883  ? 494 HOH B O   1 
HETATM 4099 O O   . HOH H 4 .   ? 18.62201  14.64569  30.96642  1.000 40.37967  ? 495 HOH B O   1 
HETATM 4100 O O   . HOH H 4 .   ? 31.33602  18.91735  12.30343  1.000 49.93560  ? 496 HOH B O   1 
HETATM 4101 O O   . HOH H 4 .   ? 34.53782  -12.34454 11.28140  1.000 38.98479  ? 497 HOH B O   1 
HETATM 4102 O O   . HOH H 4 .   ? 48.93300  4.38884   19.69892  1.000 41.37227  ? 498 HOH B O   1 
HETATM 4103 O O   . HOH H 4 .   ? 23.47842  13.77325  33.69118  1.000 33.22060  ? 499 HOH B O   1 
HETATM 4104 O O   . HOH H 4 .   ? 38.58338  -0.97805  -0.63487  1.000 44.66519  ? 500 HOH B O   1 
HETATM 4105 O O   . HOH H 4 .   ? 38.43054  0.13706   26.20744  1.000 44.17943  ? 501 HOH B O   1 
HETATM 4106 O O   . HOH H 4 .   ? 49.44754  7.02933   19.46091  1.000 44.05533  ? 502 HOH B O   1 
HETATM 4107 O O   . HOH H 4 .   ? 17.83440  -5.21041  9.48985   1.000 46.28058  ? 503 HOH B O   1 
HETATM 4108 O O   . HOH H 4 .   ? 20.99626  14.67076  30.76718  1.000 46.33358  ? 504 HOH B O   1 
HETATM 4109 O O   . HOH H 4 .   ? 31.417    -21.876   21.756    1.000 52.70574  ? 505 HOH B O   1 
HETATM 4110 O O   . HOH H 4 .   ? 21.13765  -5.32416  8.80007   1.000 40.05722  ? 506 HOH B O   1 
HETATM 4111 O O   . HOH H 4 .   ? 31.73654  3.42084   -3.68098  1.000 52.58402  ? 507 HOH B O   1 
HETATM 4112 O O   . HOH H 4 .   ? 36.62578  -2.06877  -1.79242  1.000 42.64649  ? 508 HOH B O   1 
HETATM 4113 O O   . HOH H 4 .   ? 10.53597  15.63849  29.23845  1.000 40.68356  ? 509 HOH B O   1 
HETATM 4114 O O   . HOH H 4 .   ? 32.85569  19.33436  14.30427  1.000 54.05957  ? 510 HOH B O   1 
HETATM 4115 O O   . HOH H 4 .   ? 31.26874  9.03161   32.83918  1.000 36.66215  ? 511 HOH B O   1 
HETATM 4116 O O   . HOH H 4 .   ? 32.18980  1.01118   30.26359  1.000 37.26411  ? 512 HOH B O   1 
HETATM 4117 O O   . HOH H 4 .   ? 17.00040  -5.00749  21.39593  1.000 36.40657  ? 513 HOH B O   1 
HETATM 4118 O O   . HOH H 4 .   ? 11.44381  5.06112   21.86876  1.000 42.62138  ? 514 HOH B O   1 
HETATM 4119 O O   . HOH H 4 .   ? 35.08412  10.59961  30.67125  1.000 49.55090  ? 515 HOH B O   1 
HETATM 4120 O O   . HOH H 4 .   ? 9.95205   5.06945   17.00744  1.000 62.36231  ? 516 HOH B O   1 
HETATM 4121 O O   . HOH H 4 .   ? 28.09102  3.92314   32.50029  1.000 24.66695  ? 517 HOH B O   1 
HETATM 4122 O O   . HOH H 4 .   ? 19.30948  15.70749  28.98881  1.000 42.99052  ? 518 HOH B O   1 
HETATM 4123 O O   . HOH H 4 .   ? 31.48759  5.92670   34.26686  1.000 54.31313  ? 519 HOH B O   1 
HETATM 4124 O O   . HOH H 4 .   ? 30.39780  0.83398   -3.56488  1.000 48.36292  ? 520 HOH B O   1 
HETATM 4125 O O   . HOH H 4 .   ? 49.35764  -4.71967  6.14031   1.000 58.87026  ? 521 HOH B O   1 
HETATM 4126 O O   . HOH H 4 .   ? 31.83268  2.43128   31.23113  1.000 44.52232  ? 522 HOH B O   1 
HETATM 4127 O O   . HOH H 4 .   ? 39.79929  19.36666  10.13806  1.000 45.52701  ? 523 HOH B O   1 
HETATM 4128 O O   . HOH H 4 .   ? 12.56302  3.99518   17.84602  1.000 47.64976  ? 524 HOH B O   1 
HETATM 4129 O O   . HOH H 4 .   ? 22.94044  -13.82077 17.48983  1.000 52.77988  ? 525 HOH B O   1 
HETATM 4130 O O   . HOH H 4 .   ? 40.78839  -0.63314  27.11227  1.000 48.62995  ? 526 HOH B O   1 
HETATM 4131 O O   . HOH H 4 .   ? 37.36299  12.68713  31.00594  1.000 45.38042  ? 527 HOH B O   1 
HETATM 4132 O O   . HOH H 4 .   ? 28.64815  0.80508   32.13604  1.000 45.88207  ? 528 HOH B O   1 
HETATM 4133 O O   . HOH H 4 .   ? 19.69662  -0.69064  22.13193  1.000 47.40605  ? 529 HOH B O   1 
HETATM 4134 O O   . HOH H 4 .   ? 50.75157  2.94830   18.94516  1.000 50.79270  ? 530 HOH B O   1 
HETATM 4135 O O   . HOH H 4 .   ? 29.61888  1.90182   32.74644  1.000 31.87540  ? 531 HOH B O   1 
HETATM 4136 O O   . HOH H 4 .   ? 39.07538  -2.09440  27.21987  1.000 60.00668  ? 532 HOH B O   1 
# 
