data_9DQQ
# 
_entry.id   9DQQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQQ         pdb_00009dqq 10.2210/pdb9dqq/pdb 
WWPDB D_1000288601 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume' 
2 2 'Structure model' '_citation.page_first'     
3 2 'Structure model' '_citation.page_last'      
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wchang6@ncsu.edu 
_pdbx_contact_author.name_first         Wei-chen 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2341-9846 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, Y.-C.' 1 ? 
'Chang, W.-C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            147 
_citation.language                  ? 
_citation.page_first                6162 
_citation.page_last                 6170 
_citation.title                     
;Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c17741 
_citation.pdbx_database_id_PubMed   39901767 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, Y.C.'   1  0000-0001-8509-3127 
primary 'Li, X.'        2  ?                   
primary 'Cha, L.'       3  ?                   
primary 'Paris, J.C.'   4  0000-0001-9932-5208 
primary 'Michael, C.'   5  0000-0002-7628-114X 
primary 'Ushimaru, R.'  6  0000-0002-4071-3326 
primary 'Ogasawara, Y.' 7  0000-0002-3144-3985 
primary 'Abe, I.'       8  0000-0002-3640-888X 
primary 'Guo, Y.'       9  0000-0002-4132-3565 
primary 'Chang, W.C.'   10 0000-0002-2341-9846 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '2OG-Fe dioxygenase family protein' 29345.768 2   ? ? ? ? 
2 non-polymer syn '2-OXOGLUTARIC ACID'                146.098   2   ? ? ? ? 
3 non-polymer syn 'FE (III) ION'                      55.845    3   ? ? ? ? 
4 water       nat water                               18.015    116 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '2-OXOGLUTARIC ACID' AKG 
3 'FE (III) ION'       FE  
4 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLN n 
1 3   THR n 
1 4   GLU n 
1 5   ALA n 
1 6   ARG n 
1 7   GLU n 
1 8   GLU n 
1 9   LEU n 
1 10  ARG n 
1 11  ALA n 
1 12  ASN n 
1 13  GLY n 
1 14  TYR n 
1 15  SER n 
1 16  LEU n 
1 17  LEU n 
1 18  PRO n 
1 19  ALA n 
1 20  ASP n 
1 21  ARG n 
1 22  LEU n 
1 23  VAL n 
1 24  ILE n 
1 25  ASP n 
1 26  ALA n 
1 27  GLU n 
1 28  LEU n 
1 29  ARG n 
1 30  GLN n 
1 31  HIS n 
1 32  VAL n 
1 33  LYS n 
1 34  GLU n 
1 35  LEU n 
1 36  ALA n 
1 37  ALA n 
1 38  GLU n 
1 39  TRP n 
1 40  GLU n 
1 41  ASN n 
1 42  LEU n 
1 43  GLU n 
1 44  THR n 
1 45  ASP n 
1 46  ARG n 
1 47  TYR n 
1 48  LEU n 
1 49  LYS n 
1 50  GLY n 
1 51  GLY n 
1 52  SER n 
1 53  ARG n 
1 54  PHE n 
1 55  ARG n 
1 56  GLU n 
1 57  ARG n 
1 58  ALA n 
1 59  TYR n 
1 60  ASP n 
1 61  ARG n 
1 62  PHE n 
1 63  PHE n 
1 64  PHE n 
1 65  VAL n 
1 66  PRO n 
1 67  ARG n 
1 68  THR n 
1 69  GLY n 
1 70  GLU n 
1 71  VAL n 
1 72  ARG n 
1 73  LEU n 
1 74  ARG n 
1 75  PRO n 
1 76  HIS n 
1 77  ARG n 
1 78  PRO n 
1 79  TYR n 
1 80  PHE n 
1 81  GLN n 
1 82  SER n 
1 83  MET n 
1 84  ASN n 
1 85  ALA n 
1 86  ASN n 
1 87  ASP n 
1 88  TYR n 
1 89  ALA n 
1 90  GLY n 
1 91  GLY n 
1 92  ILE n 
1 93  ASP n 
1 94  ARG n 
1 95  ASP n 
1 96  VAL n 
1 97  ALA n 
1 98  PRO n 
1 99  LEU n 
1 100 SER n 
1 101 ARG n 
1 102 THR n 
1 103 THR n 
1 104 LEU n 
1 105 ALA n 
1 106 ASN n 
1 107 PRO n 
1 108 LEU n 
1 109 LEU n 
1 110 THR n 
1 111 ARG n 
1 112 LEU n 
1 113 LEU n 
1 114 ARG n 
1 115 ALA n 
1 116 ASP n 
1 117 PHE n 
1 118 GLU n 
1 119 ASN n 
1 120 PHE n 
1 121 PRO n 
1 122 VAL n 
1 123 PRO n 
1 124 GLU n 
1 125 GLU n 
1 126 SER n 
1 127 TRP n 
1 128 LEU n 
1 129 ASP n 
1 130 ASP n 
1 131 PRO n 
1 132 TRP n 
1 133 ASP n 
1 134 VAL n 
1 135 GLN n 
1 136 CYS n 
1 137 HIS n 
1 138 GLN n 
1 139 PHE n 
1 140 ARG n 
1 141 ILE n 
1 142 ILE n 
1 143 SER n 
1 144 THR n 
1 145 PRO n 
1 146 ASP n 
1 147 GLU n 
1 148 THR n 
1 149 GLY n 
1 150 GLU n 
1 151 PRO n 
1 152 THR n 
1 153 PRO n 
1 154 GLU n 
1 155 GLY n 
1 156 PRO n 
1 157 HIS n 
1 158 ARG n 
1 159 ASP n 
1 160 GLU n 
1 161 VAL n 
1 162 ASP n 
1 163 PHE n 
1 164 GLY n 
1 165 VAL n 
1 166 ILE n 
1 167 HIS n 
1 168 LEU n 
1 169 MET n 
1 170 GLY n 
1 171 ARG n 
1 172 PHE n 
1 173 ASN n 
1 174 ALA n 
1 175 ALA n 
1 176 GLY n 
1 177 GLY n 
1 178 GLU n 
1 179 SER n 
1 180 GLN n 
1 181 VAL n 
1 182 TYR n 
1 183 SER n 
1 184 LEU n 
1 185 GLU n 
1 186 ARG n 
1 187 GLU n 
1 188 LEU n 
1 189 VAL n 
1 190 ALA n 
1 191 GLU n 
1 192 PHE n 
1 193 CYS n 
1 194 LEU n 
1 195 THR n 
1 196 GLU n 
1 197 GLN n 
1 198 MET n 
1 199 ASP n 
1 200 THR n 
1 201 MET n 
1 202 PHE n 
1 203 TRP n 
1 204 SER n 
1 205 ASP n 
1 206 GLY n 
1 207 GLN n 
1 208 ILE n 
1 209 LEU n 
1 210 HIS n 
1 211 ALA n 
1 212 VAL n 
1 213 ARG n 
1 214 PRO n 
1 215 ILE n 
1 216 HIS n 
1 217 PRO n 
1 218 VAL n 
1 219 ASP n 
1 220 PRO n 
1 221 THR n 
1 222 LYS n 
1 223 ALA n 
1 224 ALA n 
1 225 VAL n 
1 226 ARG n 
1 227 ASP n 
1 228 VAL n 
1 229 LEU n 
1 230 ILE n 
1 231 MET n 
1 232 GLY n 
1 233 TYR n 
1 234 LYS n 
1 235 HIS n 
1 236 GLU n 
1 237 PRO n 
1 238 GLU n 
1 239 LEU n 
1 240 ARG n 
1 241 ARG n 
1 242 GLU n 
1 243 GLU n 
1 244 GLN n 
1 245 GLY n 
1 246 ALA n 
1 247 ALA n 
1 248 HIS n 
1 249 HIS n 
1 250 HIS n 
1 251 HIS n 
1 252 HIS n 
1 253 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   253 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 EDD96_7010 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp. Ag109_G2-6' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2485154 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
AKG non-polymer         . '2-OXOGLUTARIC ACID' ? 'C5 H6 O5'       146.098 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'   121.158 
FE  non-polymer         . 'FE (III) ION'       ? 'Fe 3'           55.845  
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE            ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLN 2   2   2   GLN GLN A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ALA 5   5   5   ALA ALA A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   GLU 8   8   8   GLU GLU A . n 
A 1 9   LEU 9   9   9   LEU LEU A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  ASN 12  12  12  ASN ASN A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  ASP 20  20  20  ASP ASP A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  VAL 23  23  23  VAL VAL A . n 
A 1 24  ILE 24  24  24  ILE ALA A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  HIS 31  31  31  HIS HIS A . n 
A 1 32  VAL 32  32  32  VAL VAL A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  GLU 38  38  38  GLU GLU A . n 
A 1 39  TRP 39  39  39  TRP TRP A . n 
A 1 40  GLU 40  40  40  GLU GLU A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  ARG 46  46  ?   ?   ?   A . n 
A 1 47  TYR 47  47  ?   ?   ?   A . n 
A 1 48  LEU 48  48  ?   ?   ?   A . n 
A 1 49  LYS 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  GLY 51  51  ?   ?   ?   A . n 
A 1 52  SER 52  52  ?   ?   ?   A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  ARG 55  55  55  ARG ARG A . n 
A 1 56  GLU 56  56  56  GLU GLU A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  PHE 62  62  62  PHE PHE A . n 
A 1 63  PHE 63  63  63  PHE PHE A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  VAL 71  71  71  VAL VAL A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  LEU 73  73  73  LEU LEU A . n 
A 1 74  ARG 74  74  74  ARG ARG A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  HIS 76  76  76  HIS HIS A . n 
A 1 77  ARG 77  77  77  ARG ARG A . n 
A 1 78  PRO 78  78  78  PRO PRO A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  GLN 81  81  81  GLN GLN A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  ALA 89  89  89  ALA ALA A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ARG 94  94  94  ARG ARG A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  PRO 98  98  98  PRO PRO A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 ARG 101 101 101 ARG ARG A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 THR 110 110 110 THR THR A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 GLU 118 118 118 GLU GLU A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 PHE 120 120 120 PHE PHE A . n 
A 1 121 PRO 121 121 121 PRO PRO A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 GLU 124 124 124 GLU GLU A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 SER 126 126 126 SER SER A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 PRO 131 131 131 PRO PRO A . n 
A 1 132 TRP 132 132 132 TRP TRP A . n 
A 1 133 ASP 133 133 133 ASP ASP A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 CYS 136 136 136 CYS CYS A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 ASP 146 146 ?   ?   ?   A . n 
A 1 147 GLU 147 147 ?   ?   ?   A . n 
A 1 148 THR 148 148 ?   ?   ?   A . n 
A 1 149 GLY 149 149 ?   ?   ?   A . n 
A 1 150 GLU 150 150 ?   ?   ?   A . n 
A 1 151 PRO 151 151 ?   ?   ?   A . n 
A 1 152 THR 152 152 ?   ?   ?   A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 GLY 155 155 155 GLY GLY A . n 
A 1 156 PRO 156 156 156 PRO PRO A . n 
A 1 157 HIS 157 157 157 HIS HIS A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 PHE 163 163 163 PHE PHE A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 MET 169 169 169 MET MET A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 ASN 173 173 173 ASN ASN A . n 
A 1 174 ALA 174 174 174 ALA ALA A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 GLN 197 197 197 GLN GLN A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 ASP 199 199 199 ASP ASP A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 MET 201 201 201 MET MET A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 TRP 203 203 203 TRP TRP A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 GLN 207 207 207 GLN GLN A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 HIS 210 210 210 HIS HIS A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ARG 213 213 213 ARG ARG A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 HIS 216 216 216 HIS HIS A . n 
A 1 217 PRO 217 217 217 PRO PRO A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 PRO 220 220 220 PRO PRO A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 VAL 225 225 225 VAL VAL A . n 
A 1 226 ARG 226 226 226 ARG ARG A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 ILE 230 230 230 ILE ILE A . n 
A 1 231 MET 231 231 231 MET MET A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 TYR 233 233 233 TYR TYR A . n 
A 1 234 LYS 234 234 234 LYS LYS A . n 
A 1 235 HIS 235 235 235 HIS HIS A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 ARG 241 241 241 ARG ARG A . n 
A 1 242 GLU 242 242 242 GLU GLU A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 GLY 245 245 ?   ?   ?   A . n 
A 1 246 ALA 246 246 ?   ?   ?   A . n 
A 1 247 ALA 247 247 ?   ?   ?   A . n 
A 1 248 HIS 248 248 ?   ?   ?   A . n 
A 1 249 HIS 249 249 ?   ?   ?   A . n 
A 1 250 HIS 250 250 ?   ?   ?   A . n 
A 1 251 HIS 251 251 ?   ?   ?   A . n 
A 1 252 HIS 252 252 ?   ?   ?   A . n 
A 1 253 HIS 253 253 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLN 2   2   ?   ?   ?   B . n 
B 1 3   THR 3   3   3   THR THR B . n 
B 1 4   GLU 4   4   4   GLU GLU B . n 
B 1 5   ALA 5   5   5   ALA ALA B . n 
B 1 6   ARG 6   6   6   ARG ARG B . n 
B 1 7   GLU 7   7   7   GLU GLU B . n 
B 1 8   GLU 8   8   8   GLU GLU B . n 
B 1 9   LEU 9   9   9   LEU LEU B . n 
B 1 10  ARG 10  10  10  ARG ARG B . n 
B 1 11  ALA 11  11  11  ALA ALA B . n 
B 1 12  ASN 12  12  12  ASN ASN B . n 
B 1 13  GLY 13  13  13  GLY GLY B . n 
B 1 14  TYR 14  14  14  TYR TYR B . n 
B 1 15  SER 15  15  15  SER SER B . n 
B 1 16  LEU 16  16  16  LEU LEU B . n 
B 1 17  LEU 17  17  17  LEU LEU B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  ALA 19  19  19  ALA ALA B . n 
B 1 20  ASP 20  20  20  ASP ASP B . n 
B 1 21  ARG 21  21  21  ARG ARG B . n 
B 1 22  LEU 22  22  22  LEU LEU B . n 
B 1 23  VAL 23  23  23  VAL VAL B . n 
B 1 24  ILE 24  24  24  ILE ALA B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ALA 26  26  26  ALA ALA B . n 
B 1 27  GLU 27  27  27  GLU GLU B . n 
B 1 28  LEU 28  28  28  LEU LEU B . n 
B 1 29  ARG 29  29  29  ARG ARG B . n 
B 1 30  GLN 30  30  30  GLN GLN B . n 
B 1 31  HIS 31  31  31  HIS HIS B . n 
B 1 32  VAL 32  32  32  VAL VAL B . n 
B 1 33  LYS 33  33  33  LYS LYS B . n 
B 1 34  GLU 34  34  34  GLU GLU B . n 
B 1 35  LEU 35  35  35  LEU LEU B . n 
B 1 36  ALA 36  36  36  ALA ALA B . n 
B 1 37  ALA 37  37  37  ALA ALA B . n 
B 1 38  GLU 38  38  38  GLU GLU B . n 
B 1 39  TRP 39  39  39  TRP TRP B . n 
B 1 40  GLU 40  40  40  GLU GLU B . n 
B 1 41  ASN 41  41  41  ASN ASN B . n 
B 1 42  LEU 42  42  42  LEU LEU B . n 
B 1 43  GLU 43  43  43  GLU GLU B . n 
B 1 44  THR 44  44  44  THR THR B . n 
B 1 45  ASP 45  45  45  ASP ASP B . n 
B 1 46  ARG 46  46  ?   ?   ?   B . n 
B 1 47  TYR 47  47  ?   ?   ?   B . n 
B 1 48  LEU 48  48  ?   ?   ?   B . n 
B 1 49  LYS 49  49  ?   ?   ?   B . n 
B 1 50  GLY 50  50  ?   ?   ?   B . n 
B 1 51  GLY 51  51  ?   ?   ?   B . n 
B 1 52  SER 52  52  ?   ?   ?   B . n 
B 1 53  ARG 53  53  ?   ?   ?   B . n 
B 1 54  PHE 54  54  54  PHE PHE B . n 
B 1 55  ARG 55  55  55  ARG ARG B . n 
B 1 56  GLU 56  56  56  GLU GLU B . n 
B 1 57  ARG 57  57  57  ARG ARG B . n 
B 1 58  ALA 58  58  58  ALA ALA B . n 
B 1 59  TYR 59  59  59  TYR TYR B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  ARG 61  61  61  ARG ARG B . n 
B 1 62  PHE 62  62  62  PHE PHE B . n 
B 1 63  PHE 63  63  63  PHE PHE B . n 
B 1 64  PHE 64  64  64  PHE PHE B . n 
B 1 65  VAL 65  65  65  VAL VAL B . n 
B 1 66  PRO 66  66  66  PRO PRO B . n 
B 1 67  ARG 67  67  67  ARG ARG B . n 
B 1 68  THR 68  68  68  THR THR B . n 
B 1 69  GLY 69  69  69  GLY GLY B . n 
B 1 70  GLU 70  70  70  GLU GLU B . n 
B 1 71  VAL 71  71  71  VAL VAL B . n 
B 1 72  ARG 72  72  72  ARG ARG B . n 
B 1 73  LEU 73  73  73  LEU LEU B . n 
B 1 74  ARG 74  74  74  ARG ARG B . n 
B 1 75  PRO 75  75  75  PRO PRO B . n 
B 1 76  HIS 76  76  76  HIS HIS B . n 
B 1 77  ARG 77  77  77  ARG ARG B . n 
B 1 78  PRO 78  78  78  PRO PRO B . n 
B 1 79  TYR 79  79  ?   ?   ?   B . n 
B 1 80  PHE 80  80  ?   ?   ?   B . n 
B 1 81  GLN 81  81  ?   ?   ?   B . n 
B 1 82  SER 82  82  ?   ?   ?   B . n 
B 1 83  MET 83  83  ?   ?   ?   B . n 
B 1 84  ASN 84  84  ?   ?   ?   B . n 
B 1 85  ALA 85  85  ?   ?   ?   B . n 
B 1 86  ASN 86  86  ?   ?   ?   B . n 
B 1 87  ASP 87  87  ?   ?   ?   B . n 
B 1 88  TYR 88  88  ?   ?   ?   B . n 
B 1 89  ALA 89  89  ?   ?   ?   B . n 
B 1 90  GLY 90  90  ?   ?   ?   B . n 
B 1 91  GLY 91  91  ?   ?   ?   B . n 
B 1 92  ILE 92  92  ?   ?   ?   B . n 
B 1 93  ASP 93  93  ?   ?   ?   B . n 
B 1 94  ARG 94  94  ?   ?   ?   B . n 
B 1 95  ASP 95  95  ?   ?   ?   B . n 
B 1 96  VAL 96  96  96  VAL ALA B . n 
B 1 97  ALA 97  97  97  ALA ALA B . n 
B 1 98  PRO 98  98  98  PRO PRO B . n 
B 1 99  LEU 99  99  99  LEU LEU B . n 
B 1 100 SER 100 100 100 SER SER B . n 
B 1 101 ARG 101 101 101 ARG ARG B . n 
B 1 102 THR 102 102 102 THR THR B . n 
B 1 103 THR 103 103 103 THR THR B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 ALA 105 105 105 ALA ALA B . n 
B 1 106 ASN 106 106 106 ASN ASN B . n 
B 1 107 PRO 107 107 107 PRO PRO B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 LEU 109 109 109 LEU LEU B . n 
B 1 110 THR 110 110 110 THR THR B . n 
B 1 111 ARG 111 111 111 ARG ARG B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 LEU 113 113 113 LEU LEU B . n 
B 1 114 ARG 114 114 114 ARG ARG B . n 
B 1 115 ALA 115 115 115 ALA ALA B . n 
B 1 116 ASP 116 116 116 ASP ASP B . n 
B 1 117 PHE 117 117 117 PHE PHE B . n 
B 1 118 GLU 118 118 118 GLU GLU B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 PHE 120 120 120 PHE PHE B . n 
B 1 121 PRO 121 121 121 PRO PRO B . n 
B 1 122 VAL 122 122 122 VAL VAL B . n 
B 1 123 PRO 123 123 123 PRO PRO B . n 
B 1 124 GLU 124 124 124 GLU GLU B . n 
B 1 125 GLU 125 125 125 GLU GLU B . n 
B 1 126 SER 126 126 126 SER SER B . n 
B 1 127 TRP 127 127 127 TRP TRP B . n 
B 1 128 LEU 128 128 128 LEU LEU B . n 
B 1 129 ASP 129 129 129 ASP ASP B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 PRO 131 131 131 PRO PRO B . n 
B 1 132 TRP 132 132 132 TRP TRP B . n 
B 1 133 ASP 133 133 133 ASP ASP B . n 
B 1 134 VAL 134 134 134 VAL VAL B . n 
B 1 135 GLN 135 135 135 GLN GLN B . n 
B 1 136 CYS 136 136 136 CYS CYS B . n 
B 1 137 HIS 137 137 137 HIS HIS B . n 
B 1 138 GLN 138 138 138 GLN GLN B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 ARG 140 140 140 ARG ARG B . n 
B 1 141 ILE 141 141 141 ILE ILE B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 SER 143 143 143 SER SER B . n 
B 1 144 THR 144 144 ?   ?   ?   B . n 
B 1 145 PRO 145 145 ?   ?   ?   B . n 
B 1 146 ASP 146 146 ?   ?   ?   B . n 
B 1 147 GLU 147 147 ?   ?   ?   B . n 
B 1 148 THR 148 148 ?   ?   ?   B . n 
B 1 149 GLY 149 149 ?   ?   ?   B . n 
B 1 150 GLU 150 150 ?   ?   ?   B . n 
B 1 151 PRO 151 151 ?   ?   ?   B . n 
B 1 152 THR 152 152 ?   ?   ?   B . n 
B 1 153 PRO 153 153 ?   ?   ?   B . n 
B 1 154 GLU 154 154 154 GLU GLU B . n 
B 1 155 GLY 155 155 155 GLY GLY B . n 
B 1 156 PRO 156 156 156 PRO PRO B . n 
B 1 157 HIS 157 157 157 HIS HIS B . n 
B 1 158 ARG 158 158 158 ARG ARG B . n 
B 1 159 ASP 159 159 159 ASP ASP B . n 
B 1 160 GLU 160 160 160 GLU GLU B . n 
B 1 161 VAL 161 161 161 VAL VAL B . n 
B 1 162 ASP 162 162 162 ASP ASP B . n 
B 1 163 PHE 163 163 163 PHE PHE B . n 
B 1 164 GLY 164 164 164 GLY GLY B . n 
B 1 165 VAL 165 165 165 VAL VAL B . n 
B 1 166 ILE 166 166 166 ILE ILE B . n 
B 1 167 HIS 167 167 167 HIS HIS B . n 
B 1 168 LEU 168 168 168 LEU LEU B . n 
B 1 169 MET 169 169 169 MET MET B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 ARG 171 171 171 ARG ARG B . n 
B 1 172 PHE 172 172 172 PHE PHE B . n 
B 1 173 ASN 173 173 173 ASN ASN B . n 
B 1 174 ALA 174 174 174 ALA ALA B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 GLY 176 176 176 GLY GLY B . n 
B 1 177 GLY 177 177 177 GLY GLY B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 SER 179 179 179 SER SER B . n 
B 1 180 GLN 180 180 180 GLN GLN B . n 
B 1 181 VAL 181 181 181 VAL VAL B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 SER 183 183 183 SER SER B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 ARG 186 186 186 ARG ARG B . n 
B 1 187 GLU 187 187 187 GLU GLU B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 VAL 189 189 189 VAL VAL B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 GLU 191 191 191 GLU GLU B . n 
B 1 192 PHE 192 192 192 PHE PHE B . n 
B 1 193 CYS 193 193 193 CYS CYS B . n 
B 1 194 LEU 194 194 194 LEU LEU B . n 
B 1 195 THR 195 195 195 THR THR B . n 
B 1 196 GLU 196 196 196 GLU GLU B . n 
B 1 197 GLN 197 197 197 GLN GLN B . n 
B 1 198 MET 198 198 198 MET MET B . n 
B 1 199 ASP 199 199 199 ASP ASP B . n 
B 1 200 THR 200 200 200 THR THR B . n 
B 1 201 MET 201 201 201 MET MET B . n 
B 1 202 PHE 202 202 202 PHE PHE B . n 
B 1 203 TRP 203 203 203 TRP TRP B . n 
B 1 204 SER 204 204 204 SER SER B . n 
B 1 205 ASP 205 205 205 ASP ASP B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 GLN 207 207 207 GLN GLN B . n 
B 1 208 ILE 208 208 208 ILE ILE B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 HIS 210 210 210 HIS HIS B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ARG 213 213 213 ARG ARG B . n 
B 1 214 PRO 214 214 214 PRO PRO B . n 
B 1 215 ILE 215 215 215 ILE ILE B . n 
B 1 216 HIS 216 216 216 HIS HIS B . n 
B 1 217 PRO 217 217 217 PRO PRO B . n 
B 1 218 VAL 218 218 218 VAL VAL B . n 
B 1 219 ASP 219 219 219 ASP ASP B . n 
B 1 220 PRO 220 220 220 PRO PRO B . n 
B 1 221 THR 221 221 221 THR THR B . n 
B 1 222 LYS 222 222 222 LYS LYS B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 VAL 225 225 225 VAL VAL B . n 
B 1 226 ARG 226 226 226 ARG ARG B . n 
B 1 227 ASP 227 227 227 ASP ASP B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 ILE 230 230 230 ILE ILE B . n 
B 1 231 MET 231 231 231 MET MET B . n 
B 1 232 GLY 232 232 232 GLY GLY B . n 
B 1 233 TYR 233 233 233 TYR TYR B . n 
B 1 234 LYS 234 234 234 LYS LYS B . n 
B 1 235 HIS 235 235 235 HIS HIS B . n 
B 1 236 GLU 236 236 236 GLU GLU B . n 
B 1 237 PRO 237 237 237 PRO PRO B . n 
B 1 238 GLU 238 238 238 GLU GLU B . n 
B 1 239 LEU 239 239 239 LEU LEU B . n 
B 1 240 ARG 240 240 240 ARG ARG B . n 
B 1 241 ARG 241 241 241 ARG ARG B . n 
B 1 242 GLU 242 242 242 GLU GLU B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLN 244 244 ?   ?   ?   B . n 
B 1 245 GLY 245 245 ?   ?   ?   B . n 
B 1 246 ALA 246 246 ?   ?   ?   B . n 
B 1 247 ALA 247 247 ?   ?   ?   B . n 
B 1 248 HIS 248 248 ?   ?   ?   B . n 
B 1 249 HIS 249 249 ?   ?   ?   B . n 
B 1 250 HIS 250 250 ?   ?   ?   B . n 
B 1 251 HIS 251 251 ?   ?   ?   B . n 
B 1 252 HIS 252 252 ?   ?   ?   B . n 
B 1 253 HIS 253 253 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 AKG ? ? AKG ? ? 'SUBJECT OF INVESTIGATION' ? 
2 FE  ? ? FE  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 AKG 1  301 301 AKG AKG A . 
D 3 FE  1  302 302 FE  FE  A . 
E 3 FE  1  303 303 FE  FE  A . 
F 2 AKG 1  301 302 AKG AKG B . 
G 3 FE  1  302 304 FE  FE  B . 
H 4 HOH 1  401 16  HOH HOH A . 
H 4 HOH 2  402 527 HOH HOH A . 
H 4 HOH 3  403 401 HOH HOH A . 
H 4 HOH 4  404 253 HOH HOH A . 
H 4 HOH 5  405 503 HOH HOH A . 
H 4 HOH 6  406 530 HOH HOH A . 
H 4 HOH 7  407 301 HOH HOH A . 
H 4 HOH 8  408 123 HOH HOH A . 
H 4 HOH 9  409 219 HOH HOH A . 
H 4 HOH 10 410 26  HOH HOH A . 
H 4 HOH 11 411 332 HOH HOH A . 
H 4 HOH 12 412 19  HOH HOH A . 
H 4 HOH 13 413 31  HOH HOH A . 
H 4 HOH 14 414 162 HOH HOH A . 
H 4 HOH 15 415 610 HOH HOH A . 
H 4 HOH 16 416 615 HOH HOH A . 
H 4 HOH 17 417 472 HOH HOH A . 
H 4 HOH 18 418 1   HOH HOH A . 
H 4 HOH 19 419 10  HOH HOH A . 
H 4 HOH 20 420 5   HOH HOH A . 
H 4 HOH 21 421 29  HOH HOH A . 
H 4 HOH 22 422 35  HOH HOH A . 
H 4 HOH 23 423 246 HOH HOH A . 
H 4 HOH 24 424 256 HOH HOH A . 
H 4 HOH 25 425 25  HOH HOH A . 
H 4 HOH 26 426 122 HOH HOH A . 
H 4 HOH 27 427 192 HOH HOH A . 
H 4 HOH 28 428 78  HOH HOH A . 
H 4 HOH 29 429 20  HOH HOH A . 
H 4 HOH 30 430 36  HOH HOH A . 
H 4 HOH 31 431 573 HOH HOH A . 
H 4 HOH 32 432 3   HOH HOH A . 
H 4 HOH 33 433 8   HOH HOH A . 
H 4 HOH 34 434 631 HOH HOH A . 
H 4 HOH 35 435 34  HOH HOH A . 
H 4 HOH 36 436 381 HOH HOH A . 
H 4 HOH 37 437 41  HOH HOH A . 
H 4 HOH 38 438 17  HOH HOH A . 
H 4 HOH 39 439 13  HOH HOH A . 
H 4 HOH 40 440 47  HOH HOH A . 
H 4 HOH 41 441 213 HOH HOH A . 
H 4 HOH 42 442 105 HOH HOH A . 
H 4 HOH 43 443 257 HOH HOH A . 
H 4 HOH 44 444 22  HOH HOH A . 
H 4 HOH 45 445 117 HOH HOH A . 
H 4 HOH 46 446 313 HOH HOH A . 
H 4 HOH 47 447 536 HOH HOH A . 
H 4 HOH 48 448 44  HOH HOH A . 
H 4 HOH 49 449 453 HOH HOH A . 
H 4 HOH 50 450 588 HOH HOH A . 
H 4 HOH 51 451 18  HOH HOH A . 
H 4 HOH 52 452 533 HOH HOH A . 
H 4 HOH 53 453 307 HOH HOH A . 
H 4 HOH 54 454 103 HOH HOH A . 
H 4 HOH 55 455 30  HOH HOH A . 
H 4 HOH 56 456 75  HOH HOH A . 
H 4 HOH 57 457 27  HOH HOH A . 
H 4 HOH 58 458 547 HOH HOH A . 
H 4 HOH 59 459 525 HOH HOH A . 
H 4 HOH 60 460 539 HOH HOH A . 
H 4 HOH 61 461 114 HOH HOH A . 
H 4 HOH 62 462 106 HOH HOH A . 
H 4 HOH 63 463 145 HOH HOH A . 
H 4 HOH 64 464 351 HOH HOH A . 
H 4 HOH 65 465 210 HOH HOH A . 
H 4 HOH 66 466 365 HOH HOH A . 
H 4 HOH 67 467 268 HOH HOH A . 
H 4 HOH 68 468 622 HOH HOH A . 
H 4 HOH 69 469 238 HOH HOH A . 
H 4 HOH 70 470 98  HOH HOH A . 
H 4 HOH 71 471 421 HOH HOH A . 
H 4 HOH 72 472 366 HOH HOH A . 
H 4 HOH 73 473 165 HOH HOH A . 
H 4 HOH 74 474 11  HOH HOH A . 
H 4 HOH 75 475 148 HOH HOH A . 
H 4 HOH 76 476 88  HOH HOH A . 
H 4 HOH 77 477 273 HOH HOH A . 
H 4 HOH 78 478 208 HOH HOH A . 
H 4 HOH 79 479 598 HOH HOH A . 
H 4 HOH 80 480 416 HOH HOH A . 
H 4 HOH 81 481 585 HOH HOH A . 
H 4 HOH 82 482 523 HOH HOH A . 
H 4 HOH 83 483 59  HOH HOH A . 
I 4 HOH 1  401 550 HOH HOH B . 
I 4 HOH 2  402 9   HOH HOH B . 
I 4 HOH 3  403 553 HOH HOH B . 
I 4 HOH 4  404 438 HOH HOH B . 
I 4 HOH 5  405 501 HOH HOH B . 
I 4 HOH 6  406 340 HOH HOH B . 
I 4 HOH 7  407 205 HOH HOH B . 
I 4 HOH 8  408 126 HOH HOH B . 
I 4 HOH 9  409 6   HOH HOH B . 
I 4 HOH 10 410 51  HOH HOH B . 
I 4 HOH 11 411 626 HOH HOH B . 
I 4 HOH 12 412 493 HOH HOH B . 
I 4 HOH 13 413 317 HOH HOH B . 
I 4 HOH 14 414 222 HOH HOH B . 
I 4 HOH 15 415 182 HOH HOH B . 
I 4 HOH 16 416 620 HOH HOH B . 
I 4 HOH 17 417 245 HOH HOH B . 
I 4 HOH 18 418 135 HOH HOH B . 
I 4 HOH 19 419 131 HOH HOH B . 
I 4 HOH 20 420 133 HOH HOH B . 
I 4 HOH 21 421 128 HOH HOH B . 
I 4 HOH 22 422 578 HOH HOH B . 
I 4 HOH 23 423 448 HOH HOH B . 
I 4 HOH 24 424 152 HOH HOH B . 
I 4 HOH 25 425 628 HOH HOH B . 
I 4 HOH 26 426 143 HOH HOH B . 
I 4 HOH 27 427 605 HOH HOH B . 
I 4 HOH 28 428 387 HOH HOH B . 
I 4 HOH 29 429 565 HOH HOH B . 
I 4 HOH 30 430 541 HOH HOH B . 
I 4 HOH 31 431 110 HOH HOH B . 
I 4 HOH 32 432 518 HOH HOH B . 
I 4 HOH 33 433 167 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ILE 24 ? CG1 ? A ILE 24 CG1 
2 1 Y 1 A ILE 24 ? CG2 ? A ILE 24 CG2 
3 1 Y 1 A ILE 24 ? CD1 ? A ILE 24 CD1 
4 1 Y 1 B ILE 24 ? CG1 ? B ILE 24 CG1 
5 1 Y 1 B ILE 24 ? CG2 ? B ILE 24 CG2 
6 1 Y 1 B ILE 24 ? CD1 ? B ILE 24 CD1 
7 1 Y 1 B VAL 96 ? CG1 ? B VAL 96 CG1 
8 1 Y 1 B VAL 96 ? CG2 ? B VAL 96 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.21 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? .    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .    4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   106.949 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     96.871 
_cell.length_a_esd                 ? 
_cell.length_b                     43.616 
_cell.length_b_esd                 ? 
_cell.length_c                     126.201 
_cell.length_c_esd                 ? 
_cell.volume                       510060.401 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.17 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.39 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.22 M KSCN, 26% (w/v) PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-08-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU MICROMAX-007 HF' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          42.99 
_reflns.entry_id                                       9DQQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.45 
_reflns.d_resolution_low                               17.68 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18054 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.104 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.45 
_reflns_shell.d_res_low                                     2.55 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2016 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.767 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               53.89 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.45 
_refine.ls_d_res_low                             17.68 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     18045 
_refine.ls_number_reflns_R_free                  901 
_refine.ls_number_reflns_R_work                  17144 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.62 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2110 
_refine.ls_R_factor_R_free                       0.2796 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2073 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.9280 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3400 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.45 
_refine_hist.d_res_low                        17.68 
_refine_hist.number_atoms_solvent             116 
_refine_hist.number_atoms_total               3708 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3569 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         23 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0073  ? 3709 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8827  ? 5028 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0509  ? 523  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0077  ? 681  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.4544 ? 1406 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.45 2.60  . . 134 2795 94.48 . . . . 0.2459 . . . . . . . . . . . 0.2956 
'X-RAY DIFFRACTION' 2.60 2.80  . . 133 2849 95.12 . . . . 0.2405 . . . . . . . . . . . 0.3110 
'X-RAY DIFFRACTION' 2.80 3.08  . . 172 2806 95.66 . . . . 0.2338 . . . . . . . . . . . 0.3158 
'X-RAY DIFFRACTION' 3.08 3.53  . . 147 2868 96.30 . . . . 0.2139 . . . . . . . . . . . 0.3041 
'X-RAY DIFFRACTION' 3.53 4.43  . . 157 2907 96.75 . . . . 0.1814 . . . . . . . . . . . 0.2629 
'X-RAY DIFFRACTION' 4.43 17.68 . . 158 2919 95.38 . . . . 0.2011 . . . . . . . . . . . 0.2568 
# 
_struct.entry_id                     9DQQ 
_struct.title                        
'Crystal structure of HrmJ from Streptomyces sp. Ag109_G2-6 (HrmJ-ssa) complexed with ferric iron(III) and 2-oxoglutarate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQQ 
_struct_keywords.text            'hydroxylase, non-heme iron 2OG enzyme, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A3N4ZHX0_9ACTN 
_struct_ref.pdbx_db_accession          A0A3N4ZHX0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQQ A 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
2 1 9DQQ B 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQQ HIS A 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 1  
1 9DQQ HIS A 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 2  
1 9DQQ HIS A 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 3  
1 9DQQ HIS A 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 4  
1 9DQQ HIS A 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 5  
1 9DQQ HIS A 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 6  
2 9DQQ HIS B 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 7  
2 9DQQ HIS B 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 8  
2 9DQQ HIS B 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 9  
2 9DQQ HIS B 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 10 
2 9DQQ HIS B 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 11 
2 9DQQ HIS B 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 2   ? GLY A 13  ? GLN A 2   GLY A 13  1 ? 12 
HELX_P HELX_P2  AA2 PRO A 18  ? LEU A 22  ? PRO A 18  LEU A 22  5 ? 5  
HELX_P HELX_P3  AA3 ASP A 25  ? GLU A 38  ? ASP A 25  GLU A 38  1 ? 14 
HELX_P HELX_P4  AA4 TRP A 39  ? LEU A 42  ? TRP A 39  LEU A 42  5 ? 4  
HELX_P HELX_P5  AA5 PRO A 78  ? ASN A 86  ? PRO A 78  ASN A 86  1 ? 9  
HELX_P HELX_P6  AA6 SER A 100 ? ASN A 106 ? SER A 100 ASN A 106 1 ? 7  
HELX_P HELX_P7  AA7 ASN A 106 ? GLU A 118 ? ASN A 106 GLU A 118 1 ? 13 
HELX_P HELX_P8  AA8 GLU A 124 ? ASP A 130 ? GLU A 124 ASP A 130 5 ? 7  
HELX_P HELX_P9  AA9 GLU B 4   ? ASN B 12  ? GLU B 4   ASN B 12  1 ? 9  
HELX_P HELX_P10 AB1 PRO B 18  ? LEU B 22  ? PRO B 18  LEU B 22  5 ? 5  
HELX_P HELX_P11 AB2 ASP B 25  ? GLU B 38  ? ASP B 25  GLU B 38  1 ? 14 
HELX_P HELX_P12 AB3 TRP B 39  ? LEU B 42  ? TRP B 39  LEU B 42  5 ? 4  
HELX_P HELX_P13 AB4 SER B 100 ? ASN B 106 ? SER B 100 ASN B 106 1 ? 7  
HELX_P HELX_P14 AB5 PRO B 107 ? ASN B 119 ? PRO B 107 ASN B 119 1 ? 13 
HELX_P HELX_P15 AB6 GLU B 124 ? ASP B 130 ? GLU B 124 ASP B 130 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 157 NE2 ? ? ? 1_555 D FE  .  FE  ? ? A HIS 157 A FE  302 1_555 ? ? ? ? ? ? ? 2.190 ? ? 
metalc2  metalc ? ? A ASP 159 OD1 ? ? ? 1_555 D FE  .  FE  ? ? A ASP 159 A FE  302 1_555 ? ? ? ? ? ? ? 2.165 ? ? 
metalc3  metalc ? ? A THR 195 OG1 ? ? ? 1_555 E FE  .  FE  ? ? A THR 195 A FE  303 1_555 ? ? ? ? ? ? ? 2.479 ? ? 
metalc4  metalc ? ? A ASP 199 OD2 ? ? ? 1_555 E FE  .  FE  ? ? A ASP 199 A FE  303 1_555 ? ? ? ? ? ? ? 2.527 ? ? 
metalc5  metalc ? ? A HIS 210 NE2 ? ? ? 1_555 D FE  .  FE  ? ? A HIS 210 A FE  302 1_555 ? ? ? ? ? ? ? 2.091 ? ? 
metalc6  metalc ? ? C AKG .   O2  ? ? ? 1_555 D FE  .  FE  ? ? A AKG 301 A FE  302 1_555 ? ? ? ? ? ? ? 2.703 ? ? 
metalc7  metalc ? ? C AKG .   O5  ? ? ? 1_555 D FE  .  FE  ? ? A AKG 301 A FE  302 1_555 ? ? ? ? ? ? ? 2.403 ? ? 
metalc8  metalc ? ? D FE  .   FE  ? ? ? 1_555 H HOH .  O   ? ? A FE  302 A HOH 423 1_555 ? ? ? ? ? ? ? 2.109 ? ? 
metalc9  metalc ? ? E FE  .   FE  ? ? ? 1_555 B ARG 67 NH1 B ? A FE  303 B ARG 67  1_555 ? ? ? ? ? ? ? 1.973 ? ? 
metalc10 metalc ? ? B ASP 159 OD1 ? ? ? 1_555 G FE  .  FE  ? ? B ASP 159 B FE  302 1_555 ? ? ? ? ? ? ? 2.187 ? ? 
metalc11 metalc ? ? B ASP 159 OD2 ? ? ? 1_555 G FE  .  FE  ? ? B ASP 159 B FE  302 1_555 ? ? ? ? ? ? ? 2.642 ? ? 
metalc12 metalc ? ? B HIS 210 NE2 ? ? ? 1_555 G FE  .  FE  ? ? B HIS 210 B FE  302 1_555 ? ? ? ? ? ? ? 2.231 ? ? 
metalc13 metalc ? ? F AKG .   O2  ? ? ? 1_555 G FE  .  FE  ? ? B AKG 301 B FE  302 1_555 ? ? ? ? ? ? ? 2.458 ? ? 
metalc14 metalc ? ? F AKG .   O5  ? ? ? 1_555 G FE  .  FE  ? ? B AKG 301 B FE  302 1_555 ? ? ? ? ? ? ? 2.103 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 OD1 ? A ASP 159 ? A ASP 159 ? 1_555 93.3  ? 
2  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 90.7  ? 
3  OD1 ? A ASP 159 ? A ASP 159 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 90.3  ? 
4  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O2  ? C AKG .   ? A AKG 301 ? 1_555 95.4  ? 
5  OD1 ? A ASP 159 ? A ASP 159 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O2  ? C AKG .   ? A AKG 301 ? 1_555 110.7 ? 
6  NE2 ? A HIS 210 ? A HIS 210 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O2  ? C AKG .   ? A AKG 301 ? 1_555 157.6 ? 
7  NE2 ? A HIS 157 ? A HIS 157 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O5  ? C AKG .   ? A AKG 301 ? 1_555 91.4  ? 
8  OD1 ? A ASP 159 ? A ASP 159 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O5  ? C AKG .   ? A AKG 301 ? 1_555 172.8 ? 
9  NE2 ? A HIS 210 ? A HIS 210 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O5  ? C AKG .   ? A AKG 301 ? 1_555 95.1  ? 
10 O2  ? C AKG .   ? A AKG 301 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O5  ? C AKG .   ? A AKG 301 ? 1_555 63.3  ? 
11 NE2 ? A HIS 157 ? A HIS 157 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O   ? H HOH .   ? A HOH 423 ? 1_555 157.5 ? 
12 OD1 ? A ASP 159 ? A ASP 159 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O   ? H HOH .   ? A HOH 423 ? 1_555 108.4 ? 
13 NE2 ? A HIS 210 ? A HIS 210 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O   ? H HOH .   ? A HOH 423 ? 1_555 83.5  ? 
14 O2  ? C AKG .   ? A AKG 301 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O   ? H HOH .   ? A HOH 423 ? 1_555 82.7  ? 
15 O5  ? C AKG .   ? A AKG 301 ? 1_555 FE ? D FE . ? A FE 302 ? 1_555 O   ? H HOH .   ? A HOH 423 ? 1_555 67.7  ? 
16 OG1 ? A THR 195 ? A THR 195 ? 1_555 FE ? E FE . ? A FE 303 ? 1_555 OD2 ? A ASP 199 ? A ASP 199 ? 1_555 81.0  ? 
17 OG1 ? A THR 195 ? A THR 195 ? 1_555 FE ? E FE . ? A FE 303 ? 1_555 NH1 B B ARG 67  ? B ARG 67  ? 1_555 115.2 ? 
18 OD2 ? A ASP 199 ? A ASP 199 ? 1_555 FE ? E FE . ? A FE 303 ? 1_555 NH1 B B ARG 67  ? B ARG 67  ? 1_555 102.2 ? 
19 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 OD2 ? B ASP 159 ? B ASP 159 ? 1_555 52.9  ? 
20 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 97.5  ? 
21 OD2 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 82.6  ? 
22 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O2  ? F AKG .   ? B AKG 301 ? 1_555 99.9  ? 
23 OD2 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O2  ? F AKG .   ? B AKG 301 ? 1_555 98.0  ? 
24 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O2  ? F AKG .   ? B AKG 301 ? 1_555 158.5 ? 
25 OD1 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O5  ? F AKG .   ? B AKG 301 ? 1_555 157.9 ? 
26 OD2 ? B ASP 159 ? B ASP 159 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O5  ? F AKG .   ? B AKG 301 ? 1_555 106.6 ? 
27 NE2 ? B HIS 210 ? B HIS 210 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O5  ? F AKG .   ? B AKG 301 ? 1_555 86.5  ? 
28 O2  ? F AKG .   ? B AKG 301 ? 1_555 FE ? G FE . ? B FE 302 ? 1_555 O5  ? F AKG .   ? B AKG 301 ? 1_555 72.7  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 7 ? 
AA6 ? 2 ? 
AA7 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 14  ? LEU A 17  ? TYR A 14  LEU A 17  
AA1 2 THR A 200 ? SER A 204 ? THR A 200 SER A 204 
AA1 3 PHE A 163 ? PHE A 172 ? PHE A 163 PHE A 172 
AA1 4 ALA A 224 ? HIS A 235 ? ALA A 224 HIS A 235 
AA1 5 TRP A 132 ? SER A 143 ? TRP A 132 SER A 143 
AA1 6 PHE A 54  ? VAL A 65  ? PHE A 54  VAL A 65  
AA1 7 GLU A 70  ? LEU A 73  ? GLU A 70  LEU A 73  
AA2 1 ALA A 174 ? GLY A 176 ? ALA A 174 GLY A 176 
AA2 2 ILE A 215 ? PRO A 217 ? ILE A 215 PRO A 217 
AA3 1 LEU A 188 ? PHE A 192 ? LEU A 188 PHE A 192 
AA3 2 SER A 179 ? TYR A 182 ? SER A 179 TYR A 182 
AA3 3 LEU A 209 ? VAL A 212 ? LEU A 209 VAL A 212 
AA4 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA4 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA4 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA4 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA4 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA4 6 ARG B 55  ? VAL B 65  ? ARG B 55  VAL B 65  
AA4 7 GLU B 43  ? THR B 44  ? GLU B 43  THR B 44  
AA5 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA5 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA5 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA5 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA5 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA5 6 ARG B 55  ? VAL B 65  ? ARG B 55  VAL B 65  
AA5 7 GLU B 70  ? LEU B 73  ? GLU B 70  LEU B 73  
AA6 1 ALA B 174 ? GLY B 176 ? ALA B 174 GLY B 176 
AA6 2 ILE B 215 ? PRO B 217 ? ILE B 215 PRO B 217 
AA7 1 LEU B 188 ? PHE B 192 ? LEU B 188 PHE B 192 
AA7 2 SER B 179 ? TYR B 182 ? SER B 179 TYR B 182 
AA7 3 LEU B 209 ? VAL B 212 ? LEU B 209 VAL B 212 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 17  ? N LEU A 17  O THR A 200 ? O THR A 200 
AA1 2 3 O TRP A 203 ? O TRP A 203 N GLY A 164 ? N GLY A 164 
AA1 3 4 N GLY A 170 ? N GLY A 170 O ASP A 227 ? O ASP A 227 
AA1 4 5 O ILE A 230 ? O ILE A 230 N HIS A 137 ? N HIS A 137 
AA1 5 6 O CYS A 136 ? O CYS A 136 N ASP A 60  ? N ASP A 60  
AA1 6 7 N PHE A 63  ? N PHE A 63  O ARG A 72  ? O ARG A 72  
AA2 1 2 N ALA A 175 ? N ALA A 175 O HIS A 216 ? O HIS A 216 
AA3 1 2 O VAL A 189 ? O VAL A 189 N VAL A 181 ? N VAL A 181 
AA3 2 3 N GLN A 180 ? N GLN A 180 O ALA A 211 ? O ALA A 211 
AA4 1 2 N SER B 15  ? N SER B 15  O PHE B 202 ? O PHE B 202 
AA4 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA4 3 4 N PHE B 163 ? N PHE B 163 O TYR B 233 ? O TYR B 233 
AA4 4 5 O ILE B 230 ? O ILE B 230 N HIS B 137 ? N HIS B 137 
AA4 5 6 O ARG B 140 ? O ARG B 140 N GLU B 56  ? N GLU B 56  
AA4 6 7 O ARG B 57  ? O ARG B 57  N GLU B 43  ? N GLU B 43  
AA5 1 2 N SER B 15  ? N SER B 15  O PHE B 202 ? O PHE B 202 
AA5 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA5 3 4 N PHE B 163 ? N PHE B 163 O TYR B 233 ? O TYR B 233 
AA5 4 5 O ILE B 230 ? O ILE B 230 N HIS B 137 ? N HIS B 137 
AA5 5 6 O ARG B 140 ? O ARG B 140 N GLU B 56  ? N GLU B 56  
AA5 6 7 N PHE B 63  ? N PHE B 63  O ARG B 72  ? O ARG B 72  
AA6 1 2 N ALA B 175 ? N ALA B 175 O HIS B 216 ? O HIS B 216 
AA7 1 2 O PHE B 192 ? O PHE B 192 N SER B 179 ? N SER B 179 
AA7 2 3 N TYR B 182 ? N TYR B 182 O LEU B 209 ? O LEU B 209 
# 
_pdbx_entry_details.entry_id                   9DQQ 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 OE2 A GLU 70  ? ? O A HOH 401 ? ? 1.83 
2  1 O   A HOH 424 ? ? O A HOH 466 ? ? 2.00 
3  1 OE1 B GLU 125 ? ? O B HOH 401 ? ? 2.01 
4  1 OG1 A THR 68  ? ? O A HOH 402 ? ? 2.02 
5  1 OE2 B GLU 27  ? ? O B HOH 402 ? ? 2.03 
6  1 O   A HOH 414 ? ? O A HOH 475 ? ? 2.04 
7  1 O   A GLU 40  ? ? O A HOH 403 ? ? 2.08 
8  1 O   A GLU 43  ? ? O A HOH 404 ? ? 2.10 
9  1 O   A HOH 442 ? ? O A HOH 454 ? ? 2.10 
10 1 O   A HOH 403 ? ? O A HOH 463 ? ? 2.13 
11 1 O   B ILE 208 ? ? O B HOH 403 ? ? 2.14 
12 1 O   B LEU 104 ? ? O B HOH 404 ? ? 2.16 
13 1 OE1 A GLU 154 ? ? O A HOH 405 ? ? 2.17 
14 1 O   A HOH 448 ? ? O A HOH 467 ? ? 2.17 
15 1 O   A HOH 476 ? ? O A HOH 483 ? ? 2.17 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     429 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     465 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_546 
_pdbx_validate_symm_contact.dist              2.07 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 21  ? ? -67.93  6.94  
2 1 ASP A 93  ? ? -99.64  38.77 
3 1 PRO A 121 ? ? -68.48  87.23 
4 1 ASN B 41  ? ? -144.28 55.17 
5 1 MET B 198 ? ? 79.00   -2.87 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ARG 46  ? A ARG 46  
3  1 Y 1 A TYR 47  ? A TYR 47  
4  1 Y 1 A LEU 48  ? A LEU 48  
5  1 Y 1 A LYS 49  ? A LYS 49  
6  1 Y 1 A GLY 50  ? A GLY 50  
7  1 Y 1 A GLY 51  ? A GLY 51  
8  1 Y 1 A SER 52  ? A SER 52  
9  1 Y 1 A ASP 146 ? A ASP 146 
10 1 Y 1 A GLU 147 ? A GLU 147 
11 1 Y 1 A THR 148 ? A THR 148 
12 1 Y 1 A GLY 149 ? A GLY 149 
13 1 Y 1 A GLU 150 ? A GLU 150 
14 1 Y 1 A PRO 151 ? A PRO 151 
15 1 Y 1 A THR 152 ? A THR 152 
16 1 Y 1 A GLY 245 ? A GLY 245 
17 1 Y 1 A ALA 246 ? A ALA 246 
18 1 Y 1 A ALA 247 ? A ALA 247 
19 1 Y 1 A HIS 248 ? A HIS 248 
20 1 Y 1 A HIS 249 ? A HIS 249 
21 1 Y 1 A HIS 250 ? A HIS 250 
22 1 Y 1 A HIS 251 ? A HIS 251 
23 1 Y 1 A HIS 252 ? A HIS 252 
24 1 Y 1 A HIS 253 ? A HIS 253 
25 1 Y 1 B MET 1   ? B MET 1   
26 1 Y 1 B GLN 2   ? B GLN 2   
27 1 Y 1 B ARG 46  ? B ARG 46  
28 1 Y 1 B TYR 47  ? B TYR 47  
29 1 Y 1 B LEU 48  ? B LEU 48  
30 1 Y 1 B LYS 49  ? B LYS 49  
31 1 Y 1 B GLY 50  ? B GLY 50  
32 1 Y 1 B GLY 51  ? B GLY 51  
33 1 Y 1 B SER 52  ? B SER 52  
34 1 Y 1 B ARG 53  ? B ARG 53  
35 1 Y 1 B TYR 79  ? B TYR 79  
36 1 Y 1 B PHE 80  ? B PHE 80  
37 1 Y 1 B GLN 81  ? B GLN 81  
38 1 Y 1 B SER 82  ? B SER 82  
39 1 Y 1 B MET 83  ? B MET 83  
40 1 Y 1 B ASN 84  ? B ASN 84  
41 1 Y 1 B ALA 85  ? B ALA 85  
42 1 Y 1 B ASN 86  ? B ASN 86  
43 1 Y 1 B ASP 87  ? B ASP 87  
44 1 Y 1 B TYR 88  ? B TYR 88  
45 1 Y 1 B ALA 89  ? B ALA 89  
46 1 Y 1 B GLY 90  ? B GLY 90  
47 1 Y 1 B GLY 91  ? B GLY 91  
48 1 Y 1 B ILE 92  ? B ILE 92  
49 1 Y 1 B ASP 93  ? B ASP 93  
50 1 Y 1 B ARG 94  ? B ARG 94  
51 1 Y 1 B ASP 95  ? B ASP 95  
52 1 Y 1 B THR 144 ? B THR 144 
53 1 Y 1 B PRO 145 ? B PRO 145 
54 1 Y 1 B ASP 146 ? B ASP 146 
55 1 Y 1 B GLU 147 ? B GLU 147 
56 1 Y 1 B THR 148 ? B THR 148 
57 1 Y 1 B GLY 149 ? B GLY 149 
58 1 Y 1 B GLU 150 ? B GLU 150 
59 1 Y 1 B PRO 151 ? B PRO 151 
60 1 Y 1 B THR 152 ? B THR 152 
61 1 Y 1 B PRO 153 ? B PRO 153 
62 1 Y 1 B GLN 244 ? B GLN 244 
63 1 Y 1 B GLY 245 ? B GLY 245 
64 1 Y 1 B ALA 246 ? B ALA 246 
65 1 Y 1 B ALA 247 ? B ALA 247 
66 1 Y 1 B HIS 248 ? B HIS 248 
67 1 Y 1 B HIS 249 ? B HIS 249 
68 1 Y 1 B HIS 250 ? B HIS 250 
69 1 Y 1 B HIS 251 ? B HIS 251 
70 1 Y 1 B HIS 252 ? B HIS 252 
71 1 Y 1 B HIS 253 ? B HIS 253 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
AKG C1   C  N N 1   
AKG O1   O  N N 2   
AKG O2   O  N N 3   
AKG C2   C  N N 4   
AKG O5   O  N N 5   
AKG C3   C  N N 6   
AKG C4   C  N N 7   
AKG C5   C  N N 8   
AKG O3   O  N N 9   
AKG O4   O  N N 10  
AKG HO2  H  N N 11  
AKG H31  H  N N 12  
AKG H32  H  N N 13  
AKG H41  H  N N 14  
AKG H42  H  N N 15  
AKG HO4  H  N N 16  
ALA N    N  N N 17  
ALA CA   C  N S 18  
ALA C    C  N N 19  
ALA O    O  N N 20  
ALA CB   C  N N 21  
ALA OXT  O  N N 22  
ALA H    H  N N 23  
ALA H2   H  N N 24  
ALA HA   H  N N 25  
ALA HB1  H  N N 26  
ALA HB2  H  N N 27  
ALA HB3  H  N N 28  
ALA HXT  H  N N 29  
ARG N    N  N N 30  
ARG CA   C  N S 31  
ARG C    C  N N 32  
ARG O    O  N N 33  
ARG CB   C  N N 34  
ARG CG   C  N N 35  
ARG CD   C  N N 36  
ARG NE   N  N N 37  
ARG CZ   C  N N 38  
ARG NH1  N  N N 39  
ARG NH2  N  N N 40  
ARG OXT  O  N N 41  
ARG H    H  N N 42  
ARG H2   H  N N 43  
ARG HA   H  N N 44  
ARG HB2  H  N N 45  
ARG HB3  H  N N 46  
ARG HG2  H  N N 47  
ARG HG3  H  N N 48  
ARG HD2  H  N N 49  
ARG HD3  H  N N 50  
ARG HE   H  N N 51  
ARG HH11 H  N N 52  
ARG HH12 H  N N 53  
ARG HH21 H  N N 54  
ARG HH22 H  N N 55  
ARG HXT  H  N N 56  
ASN N    N  N N 57  
ASN CA   C  N S 58  
ASN C    C  N N 59  
ASN O    O  N N 60  
ASN CB   C  N N 61  
ASN CG   C  N N 62  
ASN OD1  O  N N 63  
ASN ND2  N  N N 64  
ASN OXT  O  N N 65  
ASN H    H  N N 66  
ASN H2   H  N N 67  
ASN HA   H  N N 68  
ASN HB2  H  N N 69  
ASN HB3  H  N N 70  
ASN HD21 H  N N 71  
ASN HD22 H  N N 72  
ASN HXT  H  N N 73  
ASP N    N  N N 74  
ASP CA   C  N S 75  
ASP C    C  N N 76  
ASP O    O  N N 77  
ASP CB   C  N N 78  
ASP CG   C  N N 79  
ASP OD1  O  N N 80  
ASP OD2  O  N N 81  
ASP OXT  O  N N 82  
ASP H    H  N N 83  
ASP H2   H  N N 84  
ASP HA   H  N N 85  
ASP HB2  H  N N 86  
ASP HB3  H  N N 87  
ASP HD2  H  N N 88  
ASP HXT  H  N N 89  
CYS N    N  N N 90  
CYS CA   C  N R 91  
CYS C    C  N N 92  
CYS O    O  N N 93  
CYS CB   C  N N 94  
CYS SG   S  N N 95  
CYS OXT  O  N N 96  
CYS H    H  N N 97  
CYS H2   H  N N 98  
CYS HA   H  N N 99  
CYS HB2  H  N N 100 
CYS HB3  H  N N 101 
CYS HG   H  N N 102 
CYS HXT  H  N N 103 
FE  FE   FE N N 104 
GLN N    N  N N 105 
GLN CA   C  N S 106 
GLN C    C  N N 107 
GLN O    O  N N 108 
GLN CB   C  N N 109 
GLN CG   C  N N 110 
GLN CD   C  N N 111 
GLN OE1  O  N N 112 
GLN NE2  N  N N 113 
GLN OXT  O  N N 114 
GLN H    H  N N 115 
GLN H2   H  N N 116 
GLN HA   H  N N 117 
GLN HB2  H  N N 118 
GLN HB3  H  N N 119 
GLN HG2  H  N N 120 
GLN HG3  H  N N 121 
GLN HE21 H  N N 122 
GLN HE22 H  N N 123 
GLN HXT  H  N N 124 
GLU N    N  N N 125 
GLU CA   C  N S 126 
GLU C    C  N N 127 
GLU O    O  N N 128 
GLU CB   C  N N 129 
GLU CG   C  N N 130 
GLU CD   C  N N 131 
GLU OE1  O  N N 132 
GLU OE2  O  N N 133 
GLU OXT  O  N N 134 
GLU H    H  N N 135 
GLU H2   H  N N 136 
GLU HA   H  N N 137 
GLU HB2  H  N N 138 
GLU HB3  H  N N 139 
GLU HG2  H  N N 140 
GLU HG3  H  N N 141 
GLU HE2  H  N N 142 
GLU HXT  H  N N 143 
GLY N    N  N N 144 
GLY CA   C  N N 145 
GLY C    C  N N 146 
GLY O    O  N N 147 
GLY OXT  O  N N 148 
GLY H    H  N N 149 
GLY H2   H  N N 150 
GLY HA2  H  N N 151 
GLY HA3  H  N N 152 
GLY HXT  H  N N 153 
HIS N    N  N N 154 
HIS CA   C  N S 155 
HIS C    C  N N 156 
HIS O    O  N N 157 
HIS CB   C  N N 158 
HIS CG   C  Y N 159 
HIS ND1  N  Y N 160 
HIS CD2  C  Y N 161 
HIS CE1  C  Y N 162 
HIS NE2  N  Y N 163 
HIS OXT  O  N N 164 
HIS H    H  N N 165 
HIS H2   H  N N 166 
HIS HA   H  N N 167 
HIS HB2  H  N N 168 
HIS HB3  H  N N 169 
HIS HD1  H  N N 170 
HIS HD2  H  N N 171 
HIS HE1  H  N N 172 
HIS HE2  H  N N 173 
HIS HXT  H  N N 174 
HOH O    O  N N 175 
HOH H1   H  N N 176 
HOH H2   H  N N 177 
ILE N    N  N N 178 
ILE CA   C  N S 179 
ILE C    C  N N 180 
ILE O    O  N N 181 
ILE CB   C  N S 182 
ILE CG1  C  N N 183 
ILE CG2  C  N N 184 
ILE CD1  C  N N 185 
ILE OXT  O  N N 186 
ILE H    H  N N 187 
ILE H2   H  N N 188 
ILE HA   H  N N 189 
ILE HB   H  N N 190 
ILE HG12 H  N N 191 
ILE HG13 H  N N 192 
ILE HG21 H  N N 193 
ILE HG22 H  N N 194 
ILE HG23 H  N N 195 
ILE HD11 H  N N 196 
ILE HD12 H  N N 197 
ILE HD13 H  N N 198 
ILE HXT  H  N N 199 
LEU N    N  N N 200 
LEU CA   C  N S 201 
LEU C    C  N N 202 
LEU O    O  N N 203 
LEU CB   C  N N 204 
LEU CG   C  N N 205 
LEU CD1  C  N N 206 
LEU CD2  C  N N 207 
LEU OXT  O  N N 208 
LEU H    H  N N 209 
LEU H2   H  N N 210 
LEU HA   H  N N 211 
LEU HB2  H  N N 212 
LEU HB3  H  N N 213 
LEU HG   H  N N 214 
LEU HD11 H  N N 215 
LEU HD12 H  N N 216 
LEU HD13 H  N N 217 
LEU HD21 H  N N 218 
LEU HD22 H  N N 219 
LEU HD23 H  N N 220 
LEU HXT  H  N N 221 
LYS N    N  N N 222 
LYS CA   C  N S 223 
LYS C    C  N N 224 
LYS O    O  N N 225 
LYS CB   C  N N 226 
LYS CG   C  N N 227 
LYS CD   C  N N 228 
LYS CE   C  N N 229 
LYS NZ   N  N N 230 
LYS OXT  O  N N 231 
LYS H    H  N N 232 
LYS H2   H  N N 233 
LYS HA   H  N N 234 
LYS HB2  H  N N 235 
LYS HB3  H  N N 236 
LYS HG2  H  N N 237 
LYS HG3  H  N N 238 
LYS HD2  H  N N 239 
LYS HD3  H  N N 240 
LYS HE2  H  N N 241 
LYS HE3  H  N N 242 
LYS HZ1  H  N N 243 
LYS HZ2  H  N N 244 
LYS HZ3  H  N N 245 
LYS HXT  H  N N 246 
MET N    N  N N 247 
MET CA   C  N S 248 
MET C    C  N N 249 
MET O    O  N N 250 
MET CB   C  N N 251 
MET CG   C  N N 252 
MET SD   S  N N 253 
MET CE   C  N N 254 
MET OXT  O  N N 255 
MET H    H  N N 256 
MET H2   H  N N 257 
MET HA   H  N N 258 
MET HB2  H  N N 259 
MET HB3  H  N N 260 
MET HG2  H  N N 261 
MET HG3  H  N N 262 
MET HE1  H  N N 263 
MET HE2  H  N N 264 
MET HE3  H  N N 265 
MET HXT  H  N N 266 
PHE N    N  N N 267 
PHE CA   C  N S 268 
PHE C    C  N N 269 
PHE O    O  N N 270 
PHE CB   C  N N 271 
PHE CG   C  Y N 272 
PHE CD1  C  Y N 273 
PHE CD2  C  Y N 274 
PHE CE1  C  Y N 275 
PHE CE2  C  Y N 276 
PHE CZ   C  Y N 277 
PHE OXT  O  N N 278 
PHE H    H  N N 279 
PHE H2   H  N N 280 
PHE HA   H  N N 281 
PHE HB2  H  N N 282 
PHE HB3  H  N N 283 
PHE HD1  H  N N 284 
PHE HD2  H  N N 285 
PHE HE1  H  N N 286 
PHE HE2  H  N N 287 
PHE HZ   H  N N 288 
PHE HXT  H  N N 289 
PRO N    N  N N 290 
PRO CA   C  N S 291 
PRO C    C  N N 292 
PRO O    O  N N 293 
PRO CB   C  N N 294 
PRO CG   C  N N 295 
PRO CD   C  N N 296 
PRO OXT  O  N N 297 
PRO H    H  N N 298 
PRO HA   H  N N 299 
PRO HB2  H  N N 300 
PRO HB3  H  N N 301 
PRO HG2  H  N N 302 
PRO HG3  H  N N 303 
PRO HD2  H  N N 304 
PRO HD3  H  N N 305 
PRO HXT  H  N N 306 
SER N    N  N N 307 
SER CA   C  N S 308 
SER C    C  N N 309 
SER O    O  N N 310 
SER CB   C  N N 311 
SER OG   O  N N 312 
SER OXT  O  N N 313 
SER H    H  N N 314 
SER H2   H  N N 315 
SER HA   H  N N 316 
SER HB2  H  N N 317 
SER HB3  H  N N 318 
SER HG   H  N N 319 
SER HXT  H  N N 320 
THR N    N  N N 321 
THR CA   C  N S 322 
THR C    C  N N 323 
THR O    O  N N 324 
THR CB   C  N R 325 
THR OG1  O  N N 326 
THR CG2  C  N N 327 
THR OXT  O  N N 328 
THR H    H  N N 329 
THR H2   H  N N 330 
THR HA   H  N N 331 
THR HB   H  N N 332 
THR HG1  H  N N 333 
THR HG21 H  N N 334 
THR HG22 H  N N 335 
THR HG23 H  N N 336 
THR HXT  H  N N 337 
TRP N    N  N N 338 
TRP CA   C  N S 339 
TRP C    C  N N 340 
TRP O    O  N N 341 
TRP CB   C  N N 342 
TRP CG   C  Y N 343 
TRP CD1  C  Y N 344 
TRP CD2  C  Y N 345 
TRP NE1  N  Y N 346 
TRP CE2  C  Y N 347 
TRP CE3  C  Y N 348 
TRP CZ2  C  Y N 349 
TRP CZ3  C  Y N 350 
TRP CH2  C  Y N 351 
TRP OXT  O  N N 352 
TRP H    H  N N 353 
TRP H2   H  N N 354 
TRP HA   H  N N 355 
TRP HB2  H  N N 356 
TRP HB3  H  N N 357 
TRP HD1  H  N N 358 
TRP HE1  H  N N 359 
TRP HE3  H  N N 360 
TRP HZ2  H  N N 361 
TRP HZ3  H  N N 362 
TRP HH2  H  N N 363 
TRP HXT  H  N N 364 
TYR N    N  N N 365 
TYR CA   C  N S 366 
TYR C    C  N N 367 
TYR O    O  N N 368 
TYR CB   C  N N 369 
TYR CG   C  Y N 370 
TYR CD1  C  Y N 371 
TYR CD2  C  Y N 372 
TYR CE1  C  Y N 373 
TYR CE2  C  Y N 374 
TYR CZ   C  Y N 375 
TYR OH   O  N N 376 
TYR OXT  O  N N 377 
TYR H    H  N N 378 
TYR H2   H  N N 379 
TYR HA   H  N N 380 
TYR HB2  H  N N 381 
TYR HB3  H  N N 382 
TYR HD1  H  N N 383 
TYR HD2  H  N N 384 
TYR HE1  H  N N 385 
TYR HE2  H  N N 386 
TYR HH   H  N N 387 
TYR HXT  H  N N 388 
VAL N    N  N N 389 
VAL CA   C  N S 390 
VAL C    C  N N 391 
VAL O    O  N N 392 
VAL CB   C  N N 393 
VAL CG1  C  N N 394 
VAL CG2  C  N N 395 
VAL OXT  O  N N 396 
VAL H    H  N N 397 
VAL H2   H  N N 398 
VAL HA   H  N N 399 
VAL HB   H  N N 400 
VAL HG11 H  N N 401 
VAL HG12 H  N N 402 
VAL HG13 H  N N 403 
VAL HG21 H  N N 404 
VAL HG22 H  N N 405 
VAL HG23 H  N N 406 
VAL HXT  H  N N 407 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
AKG C1  O1   doub N N 1   
AKG C1  O2   sing N N 2   
AKG C1  C2   sing N N 3   
AKG O2  HO2  sing N N 4   
AKG C2  O5   doub N N 5   
AKG C2  C3   sing N N 6   
AKG C3  C4   sing N N 7   
AKG C3  H31  sing N N 8   
AKG C3  H32  sing N N 9   
AKG C4  C5   sing N N 10  
AKG C4  H41  sing N N 11  
AKG C4  H42  sing N N 12  
AKG C5  O3   doub N N 13  
AKG C5  O4   sing N N 14  
AKG O4  HO4  sing N N 15  
ALA N   CA   sing N N 16  
ALA N   H    sing N N 17  
ALA N   H2   sing N N 18  
ALA CA  C    sing N N 19  
ALA CA  CB   sing N N 20  
ALA CA  HA   sing N N 21  
ALA C   O    doub N N 22  
ALA C   OXT  sing N N 23  
ALA CB  HB1  sing N N 24  
ALA CB  HB2  sing N N 25  
ALA CB  HB3  sing N N 26  
ALA OXT HXT  sing N N 27  
ARG N   CA   sing N N 28  
ARG N   H    sing N N 29  
ARG N   H2   sing N N 30  
ARG CA  C    sing N N 31  
ARG CA  CB   sing N N 32  
ARG CA  HA   sing N N 33  
ARG C   O    doub N N 34  
ARG C   OXT  sing N N 35  
ARG CB  CG   sing N N 36  
ARG CB  HB2  sing N N 37  
ARG CB  HB3  sing N N 38  
ARG CG  CD   sing N N 39  
ARG CG  HG2  sing N N 40  
ARG CG  HG3  sing N N 41  
ARG CD  NE   sing N N 42  
ARG CD  HD2  sing N N 43  
ARG CD  HD3  sing N N 44  
ARG NE  CZ   sing N N 45  
ARG NE  HE   sing N N 46  
ARG CZ  NH1  sing N N 47  
ARG CZ  NH2  doub N N 48  
ARG NH1 HH11 sing N N 49  
ARG NH1 HH12 sing N N 50  
ARG NH2 HH21 sing N N 51  
ARG NH2 HH22 sing N N 52  
ARG OXT HXT  sing N N 53  
ASN N   CA   sing N N 54  
ASN N   H    sing N N 55  
ASN N   H2   sing N N 56  
ASN CA  C    sing N N 57  
ASN CA  CB   sing N N 58  
ASN CA  HA   sing N N 59  
ASN C   O    doub N N 60  
ASN C   OXT  sing N N 61  
ASN CB  CG   sing N N 62  
ASN CB  HB2  sing N N 63  
ASN CB  HB3  sing N N 64  
ASN CG  OD1  doub N N 65  
ASN CG  ND2  sing N N 66  
ASN ND2 HD21 sing N N 67  
ASN ND2 HD22 sing N N 68  
ASN OXT HXT  sing N N 69  
ASP N   CA   sing N N 70  
ASP N   H    sing N N 71  
ASP N   H2   sing N N 72  
ASP CA  C    sing N N 73  
ASP CA  CB   sing N N 74  
ASP CA  HA   sing N N 75  
ASP C   O    doub N N 76  
ASP C   OXT  sing N N 77  
ASP CB  CG   sing N N 78  
ASP CB  HB2  sing N N 79  
ASP CB  HB3  sing N N 80  
ASP CG  OD1  doub N N 81  
ASP CG  OD2  sing N N 82  
ASP OD2 HD2  sing N N 83  
ASP OXT HXT  sing N N 84  
CYS N   CA   sing N N 85  
CYS N   H    sing N N 86  
CYS N   H2   sing N N 87  
CYS CA  C    sing N N 88  
CYS CA  CB   sing N N 89  
CYS CA  HA   sing N N 90  
CYS C   O    doub N N 91  
CYS C   OXT  sing N N 92  
CYS CB  SG   sing N N 93  
CYS CB  HB2  sing N N 94  
CYS CB  HB3  sing N N 95  
CYS SG  HG   sing N N 96  
CYS OXT HXT  sing N N 97  
GLN N   CA   sing N N 98  
GLN N   H    sing N N 99  
GLN N   H2   sing N N 100 
GLN CA  C    sing N N 101 
GLN CA  CB   sing N N 102 
GLN CA  HA   sing N N 103 
GLN C   O    doub N N 104 
GLN C   OXT  sing N N 105 
GLN CB  CG   sing N N 106 
GLN CB  HB2  sing N N 107 
GLN CB  HB3  sing N N 108 
GLN CG  CD   sing N N 109 
GLN CG  HG2  sing N N 110 
GLN CG  HG3  sing N N 111 
GLN CD  OE1  doub N N 112 
GLN CD  NE2  sing N N 113 
GLN NE2 HE21 sing N N 114 
GLN NE2 HE22 sing N N 115 
GLN OXT HXT  sing N N 116 
GLU N   CA   sing N N 117 
GLU N   H    sing N N 118 
GLU N   H2   sing N N 119 
GLU CA  C    sing N N 120 
GLU CA  CB   sing N N 121 
GLU CA  HA   sing N N 122 
GLU C   O    doub N N 123 
GLU C   OXT  sing N N 124 
GLU CB  CG   sing N N 125 
GLU CB  HB2  sing N N 126 
GLU CB  HB3  sing N N 127 
GLU CG  CD   sing N N 128 
GLU CG  HG2  sing N N 129 
GLU CG  HG3  sing N N 130 
GLU CD  OE1  doub N N 131 
GLU CD  OE2  sing N N 132 
GLU OE2 HE2  sing N N 133 
GLU OXT HXT  sing N N 134 
GLY N   CA   sing N N 135 
GLY N   H    sing N N 136 
GLY N   H2   sing N N 137 
GLY CA  C    sing N N 138 
GLY CA  HA2  sing N N 139 
GLY CA  HA3  sing N N 140 
GLY C   O    doub N N 141 
GLY C   OXT  sing N N 142 
GLY OXT HXT  sing N N 143 
HIS N   CA   sing N N 144 
HIS N   H    sing N N 145 
HIS N   H2   sing N N 146 
HIS CA  C    sing N N 147 
HIS CA  CB   sing N N 148 
HIS CA  HA   sing N N 149 
HIS C   O    doub N N 150 
HIS C   OXT  sing N N 151 
HIS CB  CG   sing N N 152 
HIS CB  HB2  sing N N 153 
HIS CB  HB3  sing N N 154 
HIS CG  ND1  sing Y N 155 
HIS CG  CD2  doub Y N 156 
HIS ND1 CE1  doub Y N 157 
HIS ND1 HD1  sing N N 158 
HIS CD2 NE2  sing Y N 159 
HIS CD2 HD2  sing N N 160 
HIS CE1 NE2  sing Y N 161 
HIS CE1 HE1  sing N N 162 
HIS NE2 HE2  sing N N 163 
HIS OXT HXT  sing N N 164 
HOH O   H1   sing N N 165 
HOH O   H2   sing N N 166 
ILE N   CA   sing N N 167 
ILE N   H    sing N N 168 
ILE N   H2   sing N N 169 
ILE CA  C    sing N N 170 
ILE CA  CB   sing N N 171 
ILE CA  HA   sing N N 172 
ILE C   O    doub N N 173 
ILE C   OXT  sing N N 174 
ILE CB  CG1  sing N N 175 
ILE CB  CG2  sing N N 176 
ILE CB  HB   sing N N 177 
ILE CG1 CD1  sing N N 178 
ILE CG1 HG12 sing N N 179 
ILE CG1 HG13 sing N N 180 
ILE CG2 HG21 sing N N 181 
ILE CG2 HG22 sing N N 182 
ILE CG2 HG23 sing N N 183 
ILE CD1 HD11 sing N N 184 
ILE CD1 HD12 sing N N 185 
ILE CD1 HD13 sing N N 186 
ILE OXT HXT  sing N N 187 
LEU N   CA   sing N N 188 
LEU N   H    sing N N 189 
LEU N   H2   sing N N 190 
LEU CA  C    sing N N 191 
LEU CA  CB   sing N N 192 
LEU CA  HA   sing N N 193 
LEU C   O    doub N N 194 
LEU C   OXT  sing N N 195 
LEU CB  CG   sing N N 196 
LEU CB  HB2  sing N N 197 
LEU CB  HB3  sing N N 198 
LEU CG  CD1  sing N N 199 
LEU CG  CD2  sing N N 200 
LEU CG  HG   sing N N 201 
LEU CD1 HD11 sing N N 202 
LEU CD1 HD12 sing N N 203 
LEU CD1 HD13 sing N N 204 
LEU CD2 HD21 sing N N 205 
LEU CD2 HD22 sing N N 206 
LEU CD2 HD23 sing N N 207 
LEU OXT HXT  sing N N 208 
LYS N   CA   sing N N 209 
LYS N   H    sing N N 210 
LYS N   H2   sing N N 211 
LYS CA  C    sing N N 212 
LYS CA  CB   sing N N 213 
LYS CA  HA   sing N N 214 
LYS C   O    doub N N 215 
LYS C   OXT  sing N N 216 
LYS CB  CG   sing N N 217 
LYS CB  HB2  sing N N 218 
LYS CB  HB3  sing N N 219 
LYS CG  CD   sing N N 220 
LYS CG  HG2  sing N N 221 
LYS CG  HG3  sing N N 222 
LYS CD  CE   sing N N 223 
LYS CD  HD2  sing N N 224 
LYS CD  HD3  sing N N 225 
LYS CE  NZ   sing N N 226 
LYS CE  HE2  sing N N 227 
LYS CE  HE3  sing N N 228 
LYS NZ  HZ1  sing N N 229 
LYS NZ  HZ2  sing N N 230 
LYS NZ  HZ3  sing N N 231 
LYS OXT HXT  sing N N 232 
MET N   CA   sing N N 233 
MET N   H    sing N N 234 
MET N   H2   sing N N 235 
MET CA  C    sing N N 236 
MET CA  CB   sing N N 237 
MET CA  HA   sing N N 238 
MET C   O    doub N N 239 
MET C   OXT  sing N N 240 
MET CB  CG   sing N N 241 
MET CB  HB2  sing N N 242 
MET CB  HB3  sing N N 243 
MET CG  SD   sing N N 244 
MET CG  HG2  sing N N 245 
MET CG  HG3  sing N N 246 
MET SD  CE   sing N N 247 
MET CE  HE1  sing N N 248 
MET CE  HE2  sing N N 249 
MET CE  HE3  sing N N 250 
MET OXT HXT  sing N N 251 
PHE N   CA   sing N N 252 
PHE N   H    sing N N 253 
PHE N   H2   sing N N 254 
PHE CA  C    sing N N 255 
PHE CA  CB   sing N N 256 
PHE CA  HA   sing N N 257 
PHE C   O    doub N N 258 
PHE C   OXT  sing N N 259 
PHE CB  CG   sing N N 260 
PHE CB  HB2  sing N N 261 
PHE CB  HB3  sing N N 262 
PHE CG  CD1  doub Y N 263 
PHE CG  CD2  sing Y N 264 
PHE CD1 CE1  sing Y N 265 
PHE CD1 HD1  sing N N 266 
PHE CD2 CE2  doub Y N 267 
PHE CD2 HD2  sing N N 268 
PHE CE1 CZ   doub Y N 269 
PHE CE1 HE1  sing N N 270 
PHE CE2 CZ   sing Y N 271 
PHE CE2 HE2  sing N N 272 
PHE CZ  HZ   sing N N 273 
PHE OXT HXT  sing N N 274 
PRO N   CA   sing N N 275 
PRO N   CD   sing N N 276 
PRO N   H    sing N N 277 
PRO CA  C    sing N N 278 
PRO CA  CB   sing N N 279 
PRO CA  HA   sing N N 280 
PRO C   O    doub N N 281 
PRO C   OXT  sing N N 282 
PRO CB  CG   sing N N 283 
PRO CB  HB2  sing N N 284 
PRO CB  HB3  sing N N 285 
PRO CG  CD   sing N N 286 
PRO CG  HG2  sing N N 287 
PRO CG  HG3  sing N N 288 
PRO CD  HD2  sing N N 289 
PRO CD  HD3  sing N N 290 
PRO OXT HXT  sing N N 291 
SER N   CA   sing N N 292 
SER N   H    sing N N 293 
SER N   H2   sing N N 294 
SER CA  C    sing N N 295 
SER CA  CB   sing N N 296 
SER CA  HA   sing N N 297 
SER C   O    doub N N 298 
SER C   OXT  sing N N 299 
SER CB  OG   sing N N 300 
SER CB  HB2  sing N N 301 
SER CB  HB3  sing N N 302 
SER OG  HG   sing N N 303 
SER OXT HXT  sing N N 304 
THR N   CA   sing N N 305 
THR N   H    sing N N 306 
THR N   H2   sing N N 307 
THR CA  C    sing N N 308 
THR CA  CB   sing N N 309 
THR CA  HA   sing N N 310 
THR C   O    doub N N 311 
THR C   OXT  sing N N 312 
THR CB  OG1  sing N N 313 
THR CB  CG2  sing N N 314 
THR CB  HB   sing N N 315 
THR OG1 HG1  sing N N 316 
THR CG2 HG21 sing N N 317 
THR CG2 HG22 sing N N 318 
THR CG2 HG23 sing N N 319 
THR OXT HXT  sing N N 320 
TRP N   CA   sing N N 321 
TRP N   H    sing N N 322 
TRP N   H2   sing N N 323 
TRP CA  C    sing N N 324 
TRP CA  CB   sing N N 325 
TRP CA  HA   sing N N 326 
TRP C   O    doub N N 327 
TRP C   OXT  sing N N 328 
TRP CB  CG   sing N N 329 
TRP CB  HB2  sing N N 330 
TRP CB  HB3  sing N N 331 
TRP CG  CD1  doub Y N 332 
TRP CG  CD2  sing Y N 333 
TRP CD1 NE1  sing Y N 334 
TRP CD1 HD1  sing N N 335 
TRP CD2 CE2  doub Y N 336 
TRP CD2 CE3  sing Y N 337 
TRP NE1 CE2  sing Y N 338 
TRP NE1 HE1  sing N N 339 
TRP CE2 CZ2  sing Y N 340 
TRP CE3 CZ3  doub Y N 341 
TRP CE3 HE3  sing N N 342 
TRP CZ2 CH2  doub Y N 343 
TRP CZ2 HZ2  sing N N 344 
TRP CZ3 CH2  sing Y N 345 
TRP CZ3 HZ3  sing N N 346 
TRP CH2 HH2  sing N N 347 
TRP OXT HXT  sing N N 348 
TYR N   CA   sing N N 349 
TYR N   H    sing N N 350 
TYR N   H2   sing N N 351 
TYR CA  C    sing N N 352 
TYR CA  CB   sing N N 353 
TYR CA  HA   sing N N 354 
TYR C   O    doub N N 355 
TYR C   OXT  sing N N 356 
TYR CB  CG   sing N N 357 
TYR CB  HB2  sing N N 358 
TYR CB  HB3  sing N N 359 
TYR CG  CD1  doub Y N 360 
TYR CG  CD2  sing Y N 361 
TYR CD1 CE1  sing Y N 362 
TYR CD1 HD1  sing N N 363 
TYR CD2 CE2  doub Y N 364 
TYR CD2 HD2  sing N N 365 
TYR CE1 CZ   doub Y N 366 
TYR CE1 HE1  sing N N 367 
TYR CE2 CZ   sing Y N 368 
TYR CE2 HE2  sing N N 369 
TYR CZ  OH   sing N N 370 
TYR OH  HH   sing N N 371 
TYR OXT HXT  sing N N 372 
VAL N   CA   sing N N 373 
VAL N   H    sing N N 374 
VAL N   H2   sing N N 375 
VAL CA  C    sing N N 376 
VAL CA  CB   sing N N 377 
VAL CA  HA   sing N N 378 
VAL C   O    doub N N 379 
VAL C   OXT  sing N N 380 
VAL CB  CG1  sing N N 381 
VAL CB  CG2  sing N N 382 
VAL CB  HB   sing N N 383 
VAL CG1 HG11 sing N N 384 
VAL CG1 HG12 sing N N 385 
VAL CG1 HG13 sing N N 386 
VAL CG2 HG21 sing N N 387 
VAL CG2 HG22 sing N N 388 
VAL CG2 HG23 sing N N 389 
VAL OXT HXT  sing N N 390 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9DQP 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.crystal_system   monoclinic 
_space_group.IT_number        5 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DQQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010323 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003146 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.022927 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008284 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE ? ? 20.90327 4.99816 ? ? 2.55100  38.46870 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLN A 1 2   ? 13.12674  20.23343  40.68411 1.000 47.78000  ? 2   GLN A N   1 
ATOM   2    C  CA  . GLN A 1 2   ? 11.88201  19.45782  40.69593 1.000 60.84069  ? 2   GLN A CA  1 
ATOM   3    C  C   . GLN A 1 2   ? 10.93567  19.74487  39.53311 1.000 66.59084  ? 2   GLN A C   1 
ATOM   4    O  O   . GLN A 1 2   ? 10.29896  18.81721  39.01692 1.000 66.52081  ? 2   GLN A O   1 
ATOM   5    C  CB  . GLN A 1 2   ? 11.11450  19.68372  41.99488 1.000 60.08036  ? 2   GLN A CB  1 
ATOM   6    C  CG  . GLN A 1 2   ? 11.63238  18.87586  43.15398 1.000 58.74266  ? 2   GLN A CG  1 
ATOM   7    C  CD  . GLN A 1 2   ? 12.57570  19.66232  44.01570 1.000 67.16000  ? 2   GLN A CD  1 
ATOM   8    O  OE1 . GLN A 1 2   ? 13.06151  20.72258  43.62061 1.000 79.21727  ? 2   GLN A OE1 1 
ATOM   9    N  NE2 . GLN A 1 2   ? 12.83299  19.15767  45.21466 1.000 75.85902  ? 2   GLN A NE2 1 
ATOM   10   N  N   . THR A 1 3   ? 10.81682  21.02273  39.14669 1.000 68.91966  ? 3   THR A N   1 
ATOM   11   C  CA  . THR A 1 3   ? 9.98993   21.37845  37.99214 1.000 71.17306  ? 3   THR A CA  1 
ATOM   12   C  C   . THR A 1 3   ? 10.46035  20.65398  36.73487 1.000 67.98913  ? 3   THR A C   1 
ATOM   13   O  O   . THR A 1 3   ? 9.64790   20.07831  35.99589 1.000 59.91250  ? 3   THR A O   1 
ATOM   14   C  CB  . THR A 1 3   ? 10.00800  22.89076  37.76577 1.000 66.94288  ? 3   THR A CB  1 
ATOM   15   O  OG1 . THR A 1 3   ? 11.35375  23.36505  37.88153 1.000 67.86899  ? 3   THR A OG1 1 
ATOM   16   C  CG2 . THR A 1 3   ? 9.11927   23.60069  38.77399 1.000 73.87495  ? 3   THR A CG2 1 
ATOM   17   N  N   . GLU A 1 4   ? 11.77437  20.68663  36.46731 1.000 60.68270  ? 4   GLU A N   1 
ATOM   18   C  CA  . GLU A 1 4   ? 12.30218  19.97301  35.31182 1.000 51.36331  ? 4   GLU A CA  1 
ATOM   19   C  C   . GLU A 1 4   ? 12.00934  18.48772  35.42033 1.000 55.57234  ? 4   GLU A C   1 
ATOM   20   O  O   . GLU A 1 4   ? 11.57905  17.85920  34.44255 1.000 49.27215  ? 4   GLU A O   1 
ATOM   21   C  CB  . GLU A 1 4   ? 13.80558  20.21031  35.17050 1.000 60.30328  ? 4   GLU A CB  1 
ATOM   22   C  CG  . GLU A 1 4   ? 14.47689  19.39819  34.03836 1.000 70.15121  ? 4   GLU A CG  1 
ATOM   23   C  CD  . GLU A 1 4   ? 14.13187  19.88488  32.62331 1.000 74.54286  ? 4   GLU A CD  1 
ATOM   24   O  OE1 . GLU A 1 4   ? 12.92888  20.06298  32.30559 1.000 72.22343  ? 4   GLU A OE1 1 
ATOM   25   O  OE2 . GLU A 1 4   ? 15.07487  20.08863  31.82116 1.000 73.87800  ? 4   GLU A OE2 1 
ATOM   26   N  N   . ALA A 1 5   ? 12.20548  17.91614  36.61621 1.000 58.06107  ? 5   ALA A N   1 
ATOM   27   C  CA  . ALA A 1 5   ? 11.91197  16.49960  36.81807 1.000 51.90626  ? 5   ALA A CA  1 
ATOM   28   C  C   . ALA A 1 5   ? 10.44072  16.19338  36.55372 1.000 46.73523  ? 5   ALA A C   1 
ATOM   29   O  O   . ALA A 1 5   ? 10.11224  15.15121  35.97022 1.000 44.25694  ? 5   ALA A O   1 
ATOM   30   C  CB  . ALA A 1 5   ? 12.31123  16.07323  38.23165 1.000 46.85474  ? 5   ALA A CB  1 
ATOM   31   N  N   . ARG A 1 6   ? 9.53841   17.09382  36.96051 1.000 47.59035  ? 6   ARG A N   1 
ATOM   32   C  CA  . ARG A 1 6   ? 8.11351   16.87396  36.71107 1.000 51.22525  ? 6   ARG A CA  1 
ATOM   33   C  C   . ARG A 1 6   ? 7.81446   16.83022  35.21503 1.000 48.72689  ? 6   ARG A C   1 
ATOM   34   O  O   . ARG A 1 6   ? 7.22915   15.86368  34.71193 1.000 51.03022  ? 6   ARG A O   1 
ATOM   35   C  CB  . ARG A 1 6   ? 7.27209   17.94766  37.39736 1.000 51.71216  ? 6   ARG A CB  1 
ATOM   36   C  CG  . ARG A 1 6   ? 7.15412   17.78774  38.90299 1.000 52.10902  ? 6   ARG A CG  1 
ATOM   37   C  CD  . ARG A 1 6   ? 6.30175   18.88334  39.50241 1.000 54.41350  ? 6   ARG A CD  1 
ATOM   38   N  NE  . ARG A 1 6   ? 6.58123   19.05757  40.92225 1.000 60.27221  ? 6   ARG A NE  1 
ATOM   39   C  CZ  . ARG A 1 6   ? 5.71275   19.52870  41.80826 1.000 66.60129  ? 6   ARG A CZ  1 
ATOM   40   N  NH1 . ARG A 1 6   ? 4.48563   19.89213  41.45310 1.000 69.78906  ? 6   ARG A NH1 1 
ATOM   41   N  NH2 . ARG A 1 6   ? 6.08012   19.62795  43.08471 1.000 54.02037  ? 6   ARG A NH2 1 
ATOM   42   N  N   . GLU A 1 7   ? 8.22795   17.86378  34.48115 1.000 49.12814  ? 7   GLU A N   1 
ATOM   43   C  CA  . GLU A 1 7   ? 7.99085   17.87743  33.03991 1.000 51.26902  ? 7   GLU A CA  1 
ATOM   44   C  C   . GLU A 1 7   ? 8.66041   16.69333  32.36653 1.000 41.89075  ? 7   GLU A C   1 
ATOM   45   O  O   . GLU A 1 7   ? 8.05420   16.02368  31.51731 1.000 47.80991  ? 7   GLU A O   1 
ATOM   46   C  CB  . GLU A 1 7   ? 8.48248   19.18553  32.43166 1.000 62.58606  ? 7   GLU A CB  1 
ATOM   47   C  CG  . GLU A 1 7   ? 7.43046   20.29028  32.43855 1.000 72.88485  ? 7   GLU A CG  1 
ATOM   48   C  CD  . GLU A 1 7   ? 6.28211   20.01358  31.47178 1.000 73.92771  ? 7   GLU A CD  1 
ATOM   49   O  OE1 . GLU A 1 7   ? 6.49729   19.28325  30.47151 1.000 69.42657  ? 7   GLU A OE1 1 
ATOM   50   O  OE2 . GLU A 1 7   ? 5.16600   20.53207  31.71236 1.000 68.25659  ? 7   GLU A OE2 1 
ATOM   51   N  N   . GLU A 1 8   ? 9.90728   16.40334  32.76137 1.000 41.51134  ? 8   GLU A N   1 
ATOM   52   C  CA  . GLU A 1 8   ? 10.60578  15.22409  32.24872 1.000 40.48747  ? 8   GLU A CA  1 
ATOM   53   C  C   . GLU A 1 8   ? 9.79941   13.95400  32.47616 1.000 41.41559  ? 8   GLU A C   1 
ATOM   54   O  O   . GLU A 1 8   ? 9.72013   13.09340  31.58729 1.000 40.24429  ? 8   GLU A O   1 
ATOM   55   C  CB  . GLU A 1 8   ? 11.99428  15.08368  32.88487 1.000 43.32084  ? 8   GLU A CB  1 
ATOM   56   C  CG  . GLU A 1 8   ? 13.02735  16.05332  32.32716 1.000 43.64227  ? 8   GLU A CG  1 
ATOM   57   C  CD  . GLU A 1 8   ? 14.44557  15.72958  32.75158 1.000 54.06029  ? 8   GLU A CD  1 
ATOM   58   O  OE1 . GLU A 1 8   ? 14.63398  15.17843  33.86108 1.000 50.22501  ? 8   GLU A OE1 1 
ATOM   59   O  OE2 . GLU A 1 8   ? 15.37750  16.03594  31.98011 1.000 55.76871  ? 8   GLU A OE2 1 
ATOM   60   N  N   . LEU A 1 9   ? 9.17900   13.81491  33.65444 1.000 37.49502  ? 9   LEU A N   1 
ATOM   61   C  CA  . LEU A 1 9   ? 8.34295   12.64121  33.86091 1.000 36.99735  ? 9   LEU A CA  1 
ATOM   62   C  C   . LEU A 1 9   ? 7.12531   12.68193  32.94953 1.000 37.53997  ? 9   LEU A C   1 
ATOM   63   O  O   . LEU A 1 9   ? 6.67986   11.64098  32.45533 1.000 45.16498  ? 9   LEU A O   1 
ATOM   64   C  CB  . LEU A 1 9   ? 7.93363   12.52106  35.32871 1.000 43.53561  ? 9   LEU A CB  1 
ATOM   65   C  CG  . LEU A 1 9   ? 8.67862   11.43288  36.10919 1.000 41.90904  ? 9   LEU A CG  1 
ATOM   66   C  CD1 . LEU A 1 9   ? 10.14715  11.60170  35.89639 1.000 30.94759  ? 9   LEU A CD1 1 
ATOM   67   C  CD2 . LEU A 1 9   ? 8.36883   11.49369  37.60471 1.000 34.98999  ? 9   LEU A CD2 1 
ATOM   68   N  N   . ARG A 1 10  ? 6.58814   13.87519  32.68872 1.000 37.30075  ? 10  ARG A N   1 
ATOM   69   C  CA  . ARG A 1 10  ? 5.40140   13.96722  31.83965 1.000 48.63782  ? 10  ARG A CA  1 
ATOM   70   C  C   . ARG A 1 10  ? 5.73412   13.65138  30.38725 1.000 43.51817  ? 10  ARG A C   1 
ATOM   71   O  O   . ARG A 1 10  ? 5.08216   12.80761  29.76108 1.000 39.22272  ? 10  ARG A O   1 
ATOM   72   C  CB  . ARG A 1 10  ? 4.74742   15.34201  31.97917 1.000 52.65315  ? 10  ARG A CB  1 
ATOM   73   C  CG  . ARG A 1 10  ? 3.59632   15.35756  32.98831 1.000 46.36372  ? 10  ARG A CG  1 
ATOM   74   C  CD  . ARG A 1 10  ? 2.88137   16.69841  33.04305 1.000 57.70872  ? 10  ARG A CD  1 
ATOM   75   N  NE  . ARG A 1 10  ? 3.73974   17.75412  33.57474 1.000 61.06641  ? 10  ARG A NE  1 
ATOM   76   C  CZ  . ARG A 1 10  ? 3.59499   18.32346  34.76565 1.000 63.03208  ? 10  ARG A CZ  1 
ATOM   77   N  NH1 . ARG A 1 10  ? 2.61078   17.98024  35.58137 1.000 68.28452  ? 10  ARG A NH1 1 
ATOM   78   N  NH2 . ARG A 1 10  ? 4.45775   19.26459  35.14670 1.000 57.36136  ? 10  ARG A NH2 1 
ATOM   79   N  N   . ALA A 1 11  ? 6.78078   14.27228  29.85317 1.000 37.76550  ? 11  ALA A N   1 
ATOM   80   C  CA  . ALA A 1 11  ? 7.19978   13.97051  28.48471 1.000 44.35471  ? 11  ALA A CA  1 
ATOM   81   C  C   . ALA A 1 11  ? 7.72077   12.53558  28.34512 1.000 49.64818  ? 11  ALA A C   1 
ATOM   82   O  O   . ALA A 1 11  ? 7.19515   11.74396  27.55234 1.000 53.92378  ? 11  ALA A O   1 
ATOM   83   C  CB  . ALA A 1 11  ? 8.26307   14.97168  28.03653 1.000 41.50097  ? 11  ALA A CB  1 
ATOM   84   N  N   . ASN A 1 12  ? 8.74844   12.17417  29.12615 1.000 46.90228  ? 12  ASN A N   1 
ATOM   85   C  CA  . ASN A 1 12  ? 9.52159   10.95450  28.89552 1.000 42.31892  ? 12  ASN A CA  1 
ATOM   86   C  C   . ASN A 1 12  ? 9.19559   9.81547   29.84504 1.000 40.24000  ? 12  ASN A C   1 
ATOM   87   O  O   . ASN A 1 12  ? 9.56564   8.68038   29.55045 1.000 43.32801  ? 12  ASN A O   1 
ATOM   88   C  CB  . ASN A 1 12  ? 11.02122  11.24792  29.01529 1.000 40.36960  ? 12  ASN A CB  1 
ATOM   89   C  CG  . ASN A 1 12  ? 11.39820  12.60107  28.44528 1.000 45.80471  ? 12  ASN A CG  1 
ATOM   90   O  OD1 . ASN A 1 12  ? 12.07713  13.40997  29.09271 1.000 41.60571  ? 12  ASN A OD1 1 
ATOM   91   N  ND2 . ASN A 1 12  ? 10.95322  12.85756  27.22169 1.000 49.14779  ? 12  ASN A ND2 1 
ATOM   92   N  N   . GLY A 1 13  ? 8.54214   10.08137  30.97836 1.000 44.31668  ? 13  GLY A N   1 
ATOM   93   C  CA  . GLY A 1 13  ? 8.20451   9.01945   31.91060 1.000 35.68228  ? 13  GLY A CA  1 
ATOM   94   C  C   . GLY A 1 13  ? 9.30743   8.64265   32.87912 1.000 33.55839  ? 13  GLY A C   1 
ATOM   95   O  O   . GLY A 1 13  ? 9.15209   7.66016   33.60795 1.000 33.95811  ? 13  GLY A O   1 
ATOM   96   N  N   . TYR A 1 14  ? 10.42221  9.37533   32.88443 1.000 30.79427  ? 14  TYR A N   1 
ATOM   97   C  CA  . TYR A 1 14  ? 11.53411  9.15355   33.80036 1.000 33.49068  ? 14  TYR A CA  1 
ATOM   98   C  C   . TYR A 1 14  ? 12.35782  10.42917  33.81793 1.000 26.58960  ? 14  TYR A C   1 
ATOM   99   O  O   . TYR A 1 14  ? 12.23580  11.26916  32.93010 1.000 32.55420  ? 14  TYR A O   1 
ATOM   100  C  CB  . TYR A 1 14  ? 12.41437  7.95125   33.39475 1.000 37.01666  ? 14  TYR A CB  1 
ATOM   101  C  CG  . TYR A 1 14  ? 13.23251  8.21171   32.14082 1.000 34.94021  ? 14  TYR A CG  1 
ATOM   102  C  CD1 . TYR A 1 14  ? 12.67694  8.04263   30.87560 1.000 36.65184  ? 14  TYR A CD1 1 
ATOM   103  C  CD2 . TYR A 1 14  ? 14.55183  8.64270   32.22486 1.000 34.41167  ? 14  TYR A CD2 1 
ATOM   104  C  CE1 . TYR A 1 14  ? 13.42103  8.28406   29.72780 1.000 35.55790  ? 14  TYR A CE1 1 
ATOM   105  C  CE2 . TYR A 1 14  ? 15.30686  8.88517   31.08421 1.000 36.97039  ? 14  TYR A CE2 1 
ATOM   106  C  CZ  . TYR A 1 14  ? 14.73690  8.70710   29.83367 1.000 40.36793  ? 14  TYR A CZ  1 
ATOM   107  O  OH  . TYR A 1 14  ? 15.49045  8.96140   28.69311 1.000 40.78142  ? 14  TYR A OH  1 
ATOM   108  N  N   . SER A 1 15  ? 13.19946  10.56258  34.84123 1.000 27.76090  ? 15  SER A N   1 
ATOM   109  C  CA  . SER A 1 15  ? 14.08327  11.71605  34.97791 1.000 27.20236  ? 15  SER A CA  1 
ATOM   110  C  C   . SER A 1 15  ? 15.30143  11.30336  35.78417 1.000 35.89334  ? 15  SER A C   1 
ATOM   111  O  O   . SER A 1 15  ? 15.19065  10.50123  36.71182 1.000 29.78307  ? 15  SER A O   1 
ATOM   112  C  CB  . SER A 1 15  ? 13.38475  12.89240  35.66426 1.000 35.71623  ? 15  SER A CB  1 
ATOM   113  O  OG  . SER A 1 15  ? 14.32283  13.76973  36.24334 1.000 39.73281  ? 15  SER A OG  1 
ATOM   114  N  N   . LEU A 1 16  ? 16.45231  11.86787  35.44299 1.000 34.08619  ? 16  LEU A N   1 
ATOM   115  C  CA  . LEU A 1 16  ? 17.71811  11.47190  36.03774 1.000 30.06579  ? 16  LEU A CA  1 
ATOM   116  C  C   . LEU A 1 16  ? 18.26520  12.59665  36.89963 1.000 29.64785  ? 16  LEU A C   1 
ATOM   117  O  O   . LEU A 1 16  ? 18.12743  13.77168  36.57024 1.000 40.22303  ? 16  LEU A O   1 
ATOM   118  C  CB  . LEU A 1 16  ? 18.74367  11.10574  34.95685 1.000 32.14198  ? 16  LEU A CB  1 
ATOM   119  C  CG  . LEU A 1 16  ? 18.24011  10.05487  33.96278 1.000 34.82080  ? 16  LEU A CG  1 
ATOM   120  C  CD1 . LEU A 1 16  ? 19.26605  9.78890   32.86320 1.000 40.34264  ? 16  LEU A CD1 1 
ATOM   121  C  CD2 . LEU A 1 16  ? 17.86860  8.76650   34.67218 1.000 35.55856  ? 16  LEU A CD2 1 
ATOM   122  N  N   . LEU A 1 17  ? 18.89169  12.22714  38.00406 1.000 34.65598  ? 17  LEU A N   1 
ATOM   123  C  CA  . LEU A 1 17  ? 19.49906  13.18158  38.92289 1.000 33.52238  ? 17  LEU A CA  1 
ATOM   124  C  C   . LEU A 1 17  ? 20.80886  12.56788  39.43512 1.000 33.99149  ? 17  LEU A C   1 
ATOM   125  O  O   . LEU A 1 17  ? 20.83407  11.85385  40.43400 1.000 38.08388  ? 17  LEU A O   1 
ATOM   126  C  CB  . LEU A 1 17  ? 18.53866  13.50548  40.07089 1.000 31.23720  ? 17  LEU A CB  1 
ATOM   127  C  CG  . LEU A 1 17  ? 19.09672  14.55173  41.02672 1.000 36.98341  ? 17  LEU A CG  1 
ATOM   128  C  CD1 . LEU A 1 17  ? 19.36665  15.83431  40.25393 1.000 29.03792  ? 17  LEU A CD1 1 
ATOM   129  C  CD2 . LEU A 1 17  ? 18.14724  14.78195  42.20299 1.000 31.65196  ? 17  LEU A CD2 1 
ATOM   130  N  N   . PRO A 1 18  ? 21.90348  12.80038  38.71757 1.000 40.75468  ? 18  PRO A N   1 
ATOM   131  C  CA  . PRO A 1 18  ? 23.18628  12.27911  39.21119 1.000 32.25288  ? 18  PRO A CA  1 
ATOM   132  C  C   . PRO A 1 18  ? 23.54282  12.93279  40.52631 1.000 33.93137  ? 18  PRO A C   1 
ATOM   133  O  O   . PRO A 1 18  ? 23.15924  14.06497  40.80048 1.000 37.32747  ? 18  PRO A O   1 
ATOM   134  C  CB  . PRO A 1 18  ? 24.17643  12.66857  38.10588 1.000 36.40606  ? 18  PRO A CB  1 
ATOM   135  C  CG  . PRO A 1 18  ? 23.52466  13.78785  37.37000 1.000 36.80315  ? 18  PRO A CG  1 
ATOM   136  C  CD  . PRO A 1 18  ? 22.04702  13.52462  37.44611 1.000 39.74952  ? 18  PRO A CD  1 
ATOM   137  N  N   . ALA A 1 19  ? 24.27257  12.19439  41.36352 1.000 34.41186  ? 19  ALA A N   1 
ATOM   138  C  CA  . ALA A 1 19  ? 24.74293  12.78373  42.60742 1.000 36.79692  ? 19  ALA A CA  1 
ATOM   139  C  C   . ALA A 1 19  ? 25.59430  14.03289  42.38153 1.000 43.87738  ? 19  ALA A C   1 
ATOM   140  O  O   . ALA A 1 19  ? 25.64531  14.90147  43.25864 1.000 48.05001  ? 19  ALA A O   1 
ATOM   141  C  CB  . ALA A 1 19  ? 25.54597  11.75689  43.38797 1.000 39.79587  ? 19  ALA A CB  1 
ATOM   142  N  N   . ASP A 1 20  ? 26.26558  14.13705  41.22983 1.000 46.16357  ? 20  ASP A N   1 
ATOM   143  C  CA  . ASP A 1 20  ? 27.09677  15.30737  40.95074 1.000 56.53768  ? 20  ASP A CA  1 
ATOM   144  C  C   . ASP A 1 20  ? 26.27719  16.59159  41.00424 1.000 53.46702  ? 20  ASP A C   1 
ATOM   145  O  O   . ASP A 1 20  ? 26.72171  17.59462  41.57011 1.000 55.35481  ? 20  ASP A O   1 
ATOM   146  C  CB  . ASP A 1 20  ? 27.77964  15.16217  39.58618 1.000 44.90781  ? 20  ASP A CB  1 
ATOM   147  C  CG  . ASP A 1 20  ? 29.27493  15.33443  39.66735 1.000 63.05469  ? 20  ASP A CG  1 
ATOM   148  O  OD1 . ASP A 1 20  ? 29.97534  14.37009  40.07162 1.000 70.90048  ? 20  ASP A OD1 1 
ATOM   149  O  OD2 . ASP A 1 20  ? 29.75848  16.43860  39.32967 1.000 73.47911  ? 20  ASP A OD2 1 
ATOM   150  N  N   . ARG A 1 21  ? 25.07538  16.57727  40.42452 1.000 49.20329  ? 21  ARG A N   1 
ATOM   151  C  CA  . ARG A 1 21  ? 24.11913  17.67921  40.49873 1.000 52.73451  ? 21  ARG A CA  1 
ATOM   152  C  C   . ARG A 1 21  ? 23.55010  17.88798  41.91417 1.000 64.17629  ? 21  ARG A C   1 
ATOM   153  O  O   . ARG A 1 21  ? 22.62414  18.68203  42.05339 1.000 79.76061  ? 21  ARG A O   1 
ATOM   154  C  CB  . ARG A 1 21  ? 22.96932  17.45358  39.50908 1.000 52.51211  ? 21  ARG A CB  1 
ATOM   155  C  CG  . ARG A 1 21  ? 23.38815  17.45857  38.05070 1.000 44.03650  ? 21  ARG A CG  1 
ATOM   156  C  CD  . ARG A 1 21  ? 22.21287  17.26129  37.07975 1.000 51.80200  ? 21  ARG A CD  1 
ATOM   157  N  NE  . ARG A 1 21  ? 22.73475  16.96433  35.74819 1.000 63.57629  ? 21  ARG A NE  1 
ATOM   158  C  CZ  . ARG A 1 21  ? 22.08582  16.31131  34.79207 1.000 56.71322  ? 21  ARG A CZ  1 
ATOM   159  N  NH1 . ARG A 1 21  ? 20.82461  15.92595  34.94087 1.000 54.92650  ? 21  ARG A NH1 1 
ATOM   160  N  NH2 . ARG A 1 21  ? 22.72516  16.02399  33.66097 1.000 63.49813  ? 21  ARG A NH2 1 
ATOM   161  N  N   . LEU A 1 22  ? 23.99524  17.22952  42.97805 1.000 64.31565  ? 22  LEU A N   1 
ATOM   162  C  CA  . LEU A 1 22  ? 23.53772  17.53850  44.32289 1.000 71.69902  ? 22  LEU A CA  1 
ATOM   163  C  C   . LEU A 1 22  ? 24.67346  18.17703  45.10241 1.000 64.21281  ? 22  LEU A C   1 
ATOM   164  O  O   . LEU A 1 22  ? 25.84948  17.97573  44.78995 1.000 63.51489  ? 22  LEU A O   1 
ATOM   165  C  CB  . LEU A 1 22  ? 23.03555  16.28965  45.05713 1.000 68.88042  ? 22  LEU A CB  1 
ATOM   166  C  CG  . LEU A 1 22  ? 21.56614  15.93566  44.83200 1.000 71.94028  ? 22  LEU A CG  1 
ATOM   167  C  CD1 . LEU A 1 22  ? 21.20005  14.64434  45.54562 1.000 64.53853  ? 22  LEU A CD1 1 
ATOM   168  C  CD2 . LEU A 1 22  ? 20.69229  17.08099  45.31342 1.000 85.94979  ? 22  LEU A CD2 1 
ATOM   169  N  N   . VAL A 1 23  ? 24.31398  18.96501  46.10566 1.000 74.70000  ? 23  VAL A N   1 
ATOM   170  C  CA  . VAL A 1 23  ? 25.28789  19.53446  47.02886 1.000 86.23126  ? 23  VAL A CA  1 
ATOM   171  C  C   . VAL A 1 23  ? 25.17827  18.75616  48.33385 1.000 80.71118  ? 23  VAL A C   1 
ATOM   172  O  O   . VAL A 1 23  ? 24.21612  18.92437  49.09198 1.000 75.30589  ? 23  VAL A O   1 
ATOM   173  C  CB  . VAL A 1 23  ? 25.06785  21.03787  47.24383 1.000 87.29543  ? 23  VAL A CB  1 
ATOM   174  C  CG1 . VAL A 1 23  ? 26.29719  21.65736  47.90040 1.000 74.85033  ? 23  VAL A CG1 1 
ATOM   175  C  CG2 . VAL A 1 23  ? 24.75104  21.72854  45.91710 1.000 84.40224  ? 23  VAL A CG2 1 
ATOM   176  N  N   . ILE A 1 24  ? 26.14798  17.88033  48.58764 1.000 73.15741  ? 24  ILE A N   1 
ATOM   177  C  CA  . ILE A 1 24  ? 26.15683  17.05139  49.78618 1.000 75.39728  ? 24  ILE A CA  1 
ATOM   178  C  C   . ILE A 1 24  ? 27.07356  17.70455  50.81409 1.000 73.97538  ? 24  ILE A C   1 
ATOM   179  O  O   . ILE A 1 24  ? 28.29962  17.67974  50.66633 1.000 71.81980  ? 24  ILE A O   1 
ATOM   180  C  CB  . ILE A 1 24  ? 26.60014  15.62325  49.46986 1.000 66.71036  ? 24  ILE A CB  1 
ATOM   181  N  N   . ASP A 1 25  ? 26.47689  18.29572  51.84795 1.000 66.86018  ? 25  ASP A N   1 
ATOM   182  C  CA  . ASP A 1 25  ? 27.24785  18.85761  52.94456 1.000 65.41044  ? 25  ASP A CA  1 
ATOM   183  C  C   . ASP A 1 25  ? 27.78247  17.73567  53.83068 1.000 70.17239  ? 25  ASP A C   1 
ATOM   184  O  O   . ASP A 1 25  ? 27.53292  16.54971  53.60159 1.000 69.60411  ? 25  ASP A O   1 
ATOM   185  C  CB  . ASP A 1 25  ? 26.39349  19.82351  53.76340 1.000 71.08666  ? 25  ASP A CB  1 
ATOM   186  C  CG  . ASP A 1 25  ? 25.10893  19.18850  54.26711 1.000 74.80184  ? 25  ASP A CG  1 
ATOM   187  O  OD1 . ASP A 1 25  ? 24.23707  18.88412  53.42845 1.000 89.66548  ? 25  ASP A OD1 1 
ATOM   188  O  OD2 . ASP A 1 25  ? 24.96706  18.99321  55.49405 1.000 72.28051  ? 25  ASP A OD2 1 
ATOM   189  N  N   . ALA A 1 26  ? 28.51978  18.12024  54.87315 1.000 66.57586  ? 26  ALA A N   1 
ATOM   190  C  CA  . ALA A 1 26  ? 29.08593  17.12784  55.78147 1.000 62.35029  ? 26  ALA A CA  1 
ATOM   191  C  C   . ALA A 1 26  ? 27.98878  16.31844  56.45163 1.000 56.98560  ? 26  ALA A C   1 
ATOM   192  O  O   . ALA A 1 26  ? 28.04445  15.08586  56.49311 1.000 55.91487  ? 26  ALA A O   1 
ATOM   193  C  CB  . ALA A 1 26  ? 29.95353  17.81193  56.83800 1.000 58.44771  ? 26  ALA A CB  1 
ATOM   194  N  N   . GLU A 1 27  ? 26.97575  17.00622  56.97981 1.000 64.52233  ? 27  GLU A N   1 
ATOM   195  C  CA  . GLU A 1 27  ? 25.89628  16.33388  57.69457 1.000 66.62233  ? 27  GLU A CA  1 
ATOM   196  C  C   . GLU A 1 27  ? 25.18488  15.32651  56.79916 1.000 58.30876  ? 27  GLU A C   1 
ATOM   197  O  O   . GLU A 1 27  ? 24.92241  14.18668  57.20421 1.000 52.62667  ? 27  GLU A O   1 
ATOM   198  C  CB  . GLU A 1 27  ? 24.91459  17.37513  58.23385 1.000 61.79560  ? 27  GLU A CB  1 
ATOM   199  C  CG  . GLU A 1 27  ? 23.57947  16.80929  58.69539 1.000 71.06103  ? 27  GLU A CG  1 
ATOM   200  C  CD  . GLU A 1 27  ? 22.62710  17.89032  59.15845 1.000 75.35465  ? 27  GLU A CD  1 
ATOM   201  O  OE1 . GLU A 1 27  ? 23.04036  18.69732  60.01595 1.000 77.75336  ? 27  GLU A OE1 1 
ATOM   202  O  OE2 . GLU A 1 27  ? 21.48119  17.94568  58.65278 1.000 70.10995  ? 27  GLU A OE2 1 
ATOM   203  N  N   . LEU A 1 28  ? 24.87799  15.72885  55.56955 1.000 54.90737  ? 28  LEU A N   1 
ATOM   204  C  CA  . LEU A 1 28  ? 24.13140  14.85527  54.67893 1.000 48.40895  ? 28  LEU A CA  1 
ATOM   205  C  C   . LEU A 1 28  ? 24.99051  13.67563  54.23600 1.000 48.41418  ? 28  LEU A C   1 
ATOM   206  O  O   . LEU A 1 28  ? 24.58474  12.50932  54.36812 1.000 40.75166  ? 28  LEU A O   1 
ATOM   207  C  CB  . LEU A 1 28  ? 23.62973  15.65860  53.48503 1.000 46.89137  ? 28  LEU A CB  1 
ATOM   208  C  CG  . LEU A 1 28  ? 23.03160  14.85078  52.35182 1.000 47.22755  ? 28  LEU A CG  1 
ATOM   209  C  CD1 . LEU A 1 28  ? 21.82062  14.09681  52.87016 1.000 47.09714  ? 28  LEU A CD1 1 
ATOM   210  C  CD2 . LEU A 1 28  ? 22.67626  15.77618  51.21507 1.000 53.32324  ? 28  LEU A CD2 1 
ATOM   211  N  N   . ARG A 1 29  ? 26.18828  13.96723  53.72355 1.000 40.28030  ? 29  ARG A N   1 
ATOM   212  C  CA  . ARG A 1 29  ? 27.18474  12.97600  53.33930 1.000 43.07427  ? 29  ARG A CA  1 
ATOM   213  C  C   . ARG A 1 29  ? 27.35467  11.92181  54.41767 1.000 50.95590  ? 29  ARG A C   1 
ATOM   214  O  O   . ARG A 1 29  ? 27.52340  10.73294  54.12005 1.000 40.20218  ? 29  ARG A O   1 
ATOM   215  C  CB  . ARG A 1 29  ? 28.52180  13.65719  53.08373 1.000 50.04486  ? 29  ARG A CB  1 
ATOM   216  C  CG  . ARG A 1 29  ? 29.64652  12.73163  52.70175 1.000 54.02735  ? 29  ARG A CG  1 
ATOM   217  C  CD  . ARG A 1 29  ? 30.80951  13.58151  52.18488 1.000 78.39464  ? 29  ARG A CD  1 
ATOM   218  N  NE  . ARG A 1 29  ? 30.35877  14.48110  51.12574 1.000 88.20975  ? 29  ARG A NE  1 
ATOM   219  C  CZ  . ARG A 1 29  ? 30.93451  15.63370  50.80926 1.000 85.62195  ? 29  ARG A CZ  1 
ATOM   220  N  NH1 . ARG A 1 29  ? 31.98640  16.08756  51.47483 1.000 88.61594  ? 29  ARG A NH1 1 
ATOM   221  N  NH2 . ARG A 1 29  ? 30.44248  16.34753  49.79756 1.000 71.88906  ? 29  ARG A NH2 1 
ATOM   222  N  N   . GLN A 1 30  ? 27.30392  12.35125  55.67827 1.000 40.06146  ? 30  GLN A N   1 
ATOM   223  C  CA  . GLN A 1 30  ? 27.42193  11.39654  56.76412 1.000 40.95106  ? 30  GLN A CA  1 
ATOM   224  C  C   . GLN A 1 30  ? 26.18150  10.51997  56.85598 1.000 38.64528  ? 30  GLN A C   1 
ATOM   225  O  O   . GLN A 1 30  ? 26.29087  9.29244   56.96190 1.000 35.86508  ? 30  GLN A O   1 
ATOM   226  C  CB  . GLN A 1 30  ? 27.68191  12.11654  58.08527 1.000 45.74219  ? 30  GLN A CB  1 
ATOM   227  C  CG  . GLN A 1 30  ? 28.20770  11.16158  59.14922 1.000 58.22830  ? 30  GLN A CG  1 
ATOM   228  C  CD  . GLN A 1 30  ? 29.34781  10.29271  58.62026 1.000 64.15319  ? 30  GLN A CD  1 
ATOM   229  O  OE1 . GLN A 1 30  ? 30.37372  10.80537  58.15634 1.000 66.08118  ? 30  GLN A OE1 1 
ATOM   230  N  NE2 . GLN A 1 30  ? 29.15950  8.97209   58.66474 1.000 57.11000  ? 30  GLN A NE2 1 
ATOM   231  N  N   . HIS A 1 31  ? 24.98690  11.12751  56.80515 1.000 36.00445  ? 31  HIS A N   1 
ATOM   232  C  CA  . HIS A 1 31  ? 23.76975  10.32333  56.89877 1.000 33.36744  ? 31  HIS A CA  1 
ATOM   233  C  C   . HIS A 1 31  ? 23.64485  9.37153   55.71260 1.000 30.71627  ? 31  HIS A C   1 
ATOM   234  O  O   . HIS A 1 31  ? 23.12884  8.25598   55.86113 1.000 27.09699  ? 31  HIS A O   1 
ATOM   235  C  CB  . HIS A 1 31  ? 22.54424  11.22020  57.00532 1.000 27.66395  ? 31  HIS A CB  1 
ATOM   236  C  CG  . HIS A 1 31  ? 22.42879  11.93648  58.31277 1.000 42.06655  ? 31  HIS A CG  1 
ATOM   237  N  ND1 . HIS A 1 31  ? 22.66145  11.32039  59.52718 1.000 43.15747  ? 31  HIS A ND1 1 
ATOM   238  C  CD2 . HIS A 1 31  ? 22.07931  13.21258  58.59750 1.000 33.82695  ? 31  HIS A CD2 1 
ATOM   239  C  CE1 . HIS A 1 31  ? 22.46720  12.19180  60.49878 1.000 44.57500  ? 31  HIS A CE1 1 
ATOM   240  N  NE2 . HIS A 1 31  ? 22.12026  13.34781  59.95970 1.000 39.47738  ? 31  HIS A NE2 1 
ATOM   241  N  N   . VAL A 1 32  ? 24.13857  9.78587   54.54080 1.000 27.52148  ? 32  VAL A N   1 
ATOM   242  C  CA  . VAL A 1 32  ? 24.21803  8.89048   53.39649 1.000 20.66892  ? 32  VAL A CA  1 
ATOM   243  C  C   . VAL A 1 32  ? 25.09360  7.68306   53.71328 1.000 32.46827  ? 32  VAL A C   1 
ATOM   244  O  O   . VAL A 1 32  ? 24.73778  6.53658   53.40343 1.000 32.73422  ? 32  VAL A O   1 
ATOM   245  C  CB  . VAL A 1 32  ? 24.74065  9.65437   52.17084 1.000 38.35695  ? 32  VAL A CB  1 
ATOM   246  C  CG1 . VAL A 1 32  ? 24.90734  8.70830   50.98933 1.000 27.38231  ? 32  VAL A CG1 1 
ATOM   247  C  CG2 . VAL A 1 32  ? 23.81338  10.81307  51.84914 1.000 33.41511  ? 32  VAL A CG2 1 
ATOM   248  N  N   . LYS A 1 33  ? 26.25388  7.91478   54.33582 1.000 27.31238  ? 33  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 33  ? 27.15448  6.79663   54.61946 1.000 35.71047  ? 33  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 33  ? 26.53572  5.84722   55.63321 1.000 31.22171  ? 33  LYS A C   1 
ATOM   251  O  O   . LYS A 1 33  ? 26.62560  4.61926   55.48602 1.000 29.44357  ? 33  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 33  ? 28.52344  7.30024   55.09979 1.000 42.10616  ? 33  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 33  ? 29.35098  7.99884   54.00708 1.000 41.20389  ? 33  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 33  ? 29.48099  7.07988   52.79791 1.000 45.23792  ? 33  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 33  ? 30.69640  7.42835   51.94414 1.000 57.72055  ? 33  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 33  ? 30.49163  8.63571   51.10390 1.000 51.66430  ? 33  LYS A NZ  1 
ATOM   257  N  N   . GLU A 1 34  ? 25.86891  6.40268   56.64653 1.000 28.85788  ? 34  GLU A N   1 
ATOM   258  C  CA  . GLU A 1 34  ? 25.13421  5.57807   57.59797 1.000 29.01066  ? 34  GLU A CA  1 
ATOM   259  C  C   . GLU A 1 34  ? 24.06509  4.76689   56.88943 1.000 30.34699  ? 34  GLU A C   1 
ATOM   260  O  O   . GLU A 1 34  ? 23.90588  3.57061   57.15965 1.000 33.98830  ? 34  GLU A O   1 
ATOM   261  C  CB  . GLU A 1 34  ? 24.51113  6.45298   58.69363 1.000 28.50647  ? 34  GLU A CB  1 
ATOM   262  C  CG  . GLU A 1 34  ? 25.53909  7.22456   59.48926 1.000 33.56019  ? 34  GLU A CG  1 
ATOM   263  C  CD  . GLU A 1 34  ? 24.94750  8.30708   60.40125 1.000 47.93168  ? 34  GLU A CD  1 
ATOM   264  O  OE1 . GLU A 1 34  ? 23.72810  8.60872   60.31883 1.000 43.11025  ? 34  GLU A OE1 1 
ATOM   265  O  OE2 . GLU A 1 34  ? 25.73257  8.85972   61.20338 1.000 52.76858  ? 34  GLU A OE2 1 
ATOM   266  N  N   . LEU A 1 35  ? 23.34221  5.39821   55.95168 1.000 28.61369  ? 35  LEU A N   1 
ATOM   267  C  CA  . LEU A 1 35  ? 22.27631  4.70872   55.23776 1.000 23.33356  ? 35  LEU A CA  1 
ATOM   268  C  C   . LEU A 1 35  ? 22.83393  3.59235   54.36867 1.000 27.02405  ? 35  LEU A C   1 
ATOM   269  O  O   . LEU A 1 35  ? 22.29687  2.47813   54.36195 1.000 29.10278  ? 35  LEU A O   1 
ATOM   270  C  CB  . LEU A 1 35  ? 21.48295  5.69814   54.37881 1.000 28.50206  ? 35  LEU A CB  1 
ATOM   271  C  CG  . LEU A 1 35  ? 20.33683  5.08810   53.57439 1.000 24.67200  ? 35  LEU A CG  1 
ATOM   272  C  CD1 . LEU A 1 35  ? 19.43398  4.28353   54.50134 1.000 14.84638  ? 35  LEU A CD1 1 
ATOM   273  C  CD2 . LEU A 1 35  ? 19.52000  6.12934   52.80663 1.000 24.86147  ? 35  LEU A CD2 1 
ATOM   274  N  N   . ALA A 1 36  ? 23.91250  3.86955   53.63067 1.000 25.05097  ? 36  ALA A N   1 
ATOM   275  C  CA  . ALA A 1 36  ? 24.48923  2.86020   52.73322 1.000 24.69631  ? 36  ALA A CA  1 
ATOM   276  C  C   . ALA A 1 36  ? 25.03373  1.66688   53.51706 1.000 32.35252  ? 36  ALA A C   1 
ATOM   277  O  O   . ALA A 1 36  ? 24.89988  0.51693   53.08307 1.000 36.30552  ? 36  ALA A O   1 
ATOM   278  C  CB  . ALA A 1 36  ? 25.58360  3.49331   51.86486 1.000 21.67734  ? 36  ALA A CB  1 
ATOM   279  N  N   . ALA A 1 37  ? 25.59830  1.92132   54.70181 1.000 27.24807  ? 37  ALA A N   1 
ATOM   280  C  CA  . ALA A 1 37  ? 26.19474  0.85623   55.50224 1.000 31.94834  ? 37  ALA A CA  1 
ATOM   281  C  C   . ALA A 1 37  ? 25.16821  -0.18572  55.90512 1.000 32.48573  ? 37  ALA A C   1 
ATOM   282  O  O   . ALA A 1 37  ? 25.49823  -1.36750  55.99458 1.000 36.21315  ? 37  ALA A O   1 
ATOM   283  C  CB  . ALA A 1 37  ? 26.87447  1.44315   56.74808 1.000 22.98902  ? 37  ALA A CB  1 
ATOM   284  N  N   . GLU A 1 38  ? 23.91562  0.22326   56.10942 1.000 34.50910  ? 38  GLU A N   1 
ATOM   285  C  CA  . GLU A 1 38  ? 22.83319  -0.73026  56.33855 1.000 28.47418  ? 38  GLU A CA  1 
ATOM   286  C  C   . GLU A 1 38  ? 22.79819  -1.87202  55.33086 1.000 34.97235  ? 38  GLU A C   1 
ATOM   287  O  O   . GLU A 1 38  ? 22.28893  -2.95718  55.64616 1.000 35.17957  ? 38  GLU A O   1 
ATOM   288  C  CB  . GLU A 1 38  ? 21.50836  -0.00286  56.28498 1.000 24.89900  ? 38  GLU A CB  1 
ATOM   289  C  CG  . GLU A 1 38  ? 21.37847  1.05955   57.33104 1.000 30.99064  ? 38  GLU A CG  1 
ATOM   290  C  CD  . GLU A 1 38  ? 21.26432  0.48670   58.71809 1.000 29.76110  ? 38  GLU A CD  1 
ATOM   291  O  OE1 . GLU A 1 38  ? 20.79060  -0.66748  58.88327 1.000 31.38735  ? 38  GLU A OE1 1 
ATOM   292  O  OE2 . GLU A 1 38  ? 21.65339  1.21027   59.64840 1.000 35.85242  ? 38  GLU A OE2 1 
ATOM   293  N  N   . TRP A 1 39  ? 23.27893  -1.64495  54.10463 1.000 27.46429  ? 39  TRP A N   1 
ATOM   294  C  CA  . TRP A 1 39  ? 23.21115  -2.70742  53.10509 1.000 34.87055  ? 39  TRP A CA  1 
ATOM   295  C  C   . TRP A 1 39  ? 24.18754  -3.82922  53.40428 1.000 40.98691  ? 39  TRP A C   1 
ATOM   296  O  O   . TRP A 1 39  ? 24.05039  -4.91693  52.83057 1.000 40.63848  ? 39  TRP A O   1 
ATOM   297  C  CB  . TRP A 1 39  ? 23.46081  -2.13289  51.69451 1.000 36.33171  ? 39  TRP A CB  1 
ATOM   298  C  CG  . TRP A 1 39  ? 22.21130  -1.65842  50.98151 1.000 30.16539  ? 39  TRP A CG  1 
ATOM   299  C  CD1 . TRP A 1 39  ? 21.61419  -2.23831  49.89582 1.000 23.93956  ? 39  TRP A CD1 1 
ATOM   300  C  CD2 . TRP A 1 39  ? 21.39768  -0.53086  51.32681 1.000 20.28817  ? 39  TRP A CD2 1 
ATOM   301  N  NE1 . TRP A 1 39  ? 20.49164  -1.54640  49.54491 1.000 22.55571  ? 39  TRP A NE1 1 
ATOM   302  C  CE2 . TRP A 1 39  ? 20.33602  -0.48739  50.40495 1.000 27.57737  ? 39  TRP A CE2 1 
ATOM   303  C  CE3 . TRP A 1 39  ? 21.46358  0.44178   52.32236 1.000 24.23600  ? 39  TRP A CE3 1 
ATOM   304  C  CZ2 . TRP A 1 39  ? 19.34195  0.50530   50.44896 1.000 26.48734  ? 39  TRP A CZ2 1 
ATOM   305  C  CZ3 . TRP A 1 39  ? 20.47547  1.43143   52.36049 1.000 26.71340  ? 39  TRP A CZ3 1 
ATOM   306  C  CH2 . TRP A 1 39  ? 19.43039  1.44536   51.43245 1.000 22.01621  ? 39  TRP A CH2 1 
ATOM   307  N  N   . GLU A 1 40  ? 25.17235  -3.58212  54.26816 1.000 37.61219  ? 40  GLU A N   1 
ATOM   308  C  CA  . GLU A 1 40  ? 26.07714  -4.63048  54.70182 1.000 43.92362  ? 40  GLU A CA  1 
ATOM   309  C  C   . GLU A 1 40  ? 25.43233  -5.58918  55.69044 1.000 44.83959  ? 40  GLU A C   1 
ATOM   310  O  O   . GLU A 1 40  ? 26.06074  -6.58680  56.04962 1.000 56.08622  ? 40  GLU A O   1 
ATOM   311  C  CB  . GLU A 1 40  ? 27.34822  -4.02879  55.31087 1.000 37.19150  ? 40  GLU A CB  1 
ATOM   312  C  CG  . GLU A 1 40  ? 28.17008  -3.09447  54.39920 1.000 38.33849  ? 40  GLU A CG  1 
ATOM   313  C  CD  . GLU A 1 40  ? 28.90504  -3.80048  53.25707 1.000 46.07050  ? 40  GLU A CD  1 
ATOM   314  O  OE1 . GLU A 1 40  ? 28.97046  -5.05077  53.28838 1.000 55.48000  ? 40  GLU A OE1 1 
ATOM   315  O  OE2 . GLU A 1 40  ? 29.40671  -3.10791  52.32943 1.000 52.15058  ? 40  GLU A OE2 1 
ATOM   316  N  N   . ASN A 1 41  ? 24.18908  -5.33655  56.11633 1.000 39.73760  ? 41  ASN A N   1 
ATOM   317  C  CA  . ASN A 1 41  ? 23.56896  -6.11745  57.18102 1.000 34.45112  ? 41  ASN A CA  1 
ATOM   318  C  C   . ASN A 1 41  ? 22.18212  -6.64641  56.85553 1.000 29.98089  ? 41  ASN A C   1 
ATOM   319  O  O   . ASN A 1 41  ? 21.41992  -6.94730  57.76716 1.000 49.27000  ? 41  ASN A O   1 
ATOM   320  C  CB  . ASN A 1 41  ? 23.52606  -5.27629  58.45342 1.000 27.06446  ? 41  ASN A CB  1 
ATOM   321  C  CG  . ASN A 1 41  ? 24.89885  -4.84163  58.88872 1.000 52.06063  ? 41  ASN A CG  1 
ATOM   322  O  OD1 . ASN A 1 41  ? 25.15626  -3.63010  59.04132 1.000 69.63076  ? 41  ASN A OD1 1 
ATOM   323  N  ND2 . ASN A 1 41  ? 25.81887  -5.80389  59.04902 1.000 51.89037  ? 41  ASN A ND2 1 
ATOM   324  N  N   . LEU A 1 42  ? 21.85718  -6.77563  55.58998 1.000 35.03380  ? 42  LEU A N   1 
ATOM   325  C  CA  . LEU A 1 42  ? 20.58513  -7.35587  55.20618 1.000 42.92294  ? 42  LEU A CA  1 
ATOM   326  C  C   . LEU A 1 42  ? 20.62350  -8.87201  55.35182 1.000 54.51273  ? 42  LEU A C   1 
ATOM   327  O  O   . LEU A 1 42  ? 21.69407  -9.47794  55.36575 1.000 50.21028  ? 42  LEU A O   1 
ATOM   328  C  CB  . LEU A 1 42  ? 20.21188  -6.96377  53.77535 1.000 34.02538  ? 42  LEU A CB  1 
ATOM   329  C  CG  . LEU A 1 42  ? 20.33753  -5.50815  53.38869 1.000 33.80665  ? 42  LEU A CG  1 
ATOM   330  C  CD1 . LEU A 1 42  ? 20.35336  -5.34324  51.88049 1.000 27.79778  ? 42  LEU A CD1 1 
ATOM   331  C  CD2 . LEU A 1 42  ? 19.14915  -4.72531  53.98056 1.000 33.72758  ? 42  LEU A CD2 1 
ATOM   332  N  N   . GLU A 1 43  ? 19.43090  -9.48502  55.42715 1.000 52.88686  ? 43  GLU A N   1 
ATOM   333  C  CA  . GLU A 1 43  ? 19.33243  -10.93257 55.61637 1.000 62.09744  ? 43  GLU A CA  1 
ATOM   334  C  C   . GLU A 1 43  ? 19.72783  -11.69665 54.34917 1.000 64.60616  ? 43  GLU A C   1 
ATOM   335  O  O   . GLU A 1 43  ? 19.38204  -11.29737 53.23446 1.000 55.56002  ? 43  GLU A O   1 
ATOM   336  C  CB  . GLU A 1 43  ? 17.91837  -11.29832 56.05236 1.000 63.09375  ? 43  GLU A CB  1 
ATOM   337  C  CG  . GLU A 1 43  ? 17.62810  -10.85571 57.47883 1.000 60.36161  ? 43  GLU A CG  1 
ATOM   338  C  CD  . GLU A 1 43  ? 18.72382  -11.30243 58.43093 1.000 74.06413  ? 43  GLU A CD  1 
ATOM   339  O  OE1 . GLU A 1 43  ? 18.96860  -12.52642 58.50908 1.000 78.12306  ? 43  GLU A OE1 1 
ATOM   340  O  OE2 . GLU A 1 43  ? 19.35415  -10.43846 59.08679 1.000 76.73802  ? 43  GLU A OE2 1 
ATOM   341  N  N   . THR A 1 44  ? 20.44315  -12.81674 54.53547 1.000 71.93682  ? 44  THR A N   1 
ATOM   342  C  CA  . THR A 1 44  ? 21.06801  -13.57699 53.45540 1.000 71.24552  ? 44  THR A CA  1 
ATOM   343  C  C   . THR A 1 44  ? 20.07198  -14.26356 52.53064 1.000 75.04780  ? 44  THR A C   1 
ATOM   344  O  O   . THR A 1 44  ? 20.46171  -14.68523 51.43449 1.000 73.37552  ? 44  THR A O   1 
ATOM   345  C  CB  . THR A 1 44  ? 22.01615  -14.63242 54.03901 1.000 83.77982  ? 44  THR A CB  1 
ATOM   346  O  OG1 . THR A 1 44  ? 21.72508  -14.84070 55.43212 1.000 74.05122  ? 44  THR A OG1 1 
ATOM   347  C  CG2 . THR A 1 44  ? 23.49105  -14.21395 53.86709 1.000 77.78395  ? 44  THR A CG2 1 
ATOM   348  N  N   . ASP A 1 45  ? 18.81688  -14.39791 52.92949 1.000 65.66292  ? 45  ASP A N   1 
ATOM   349  C  CA  . ASP A 1 45  ? 17.84601  -15.03813 52.05845 1.000 79.13969  ? 45  ASP A CA  1 
ATOM   350  C  C   . ASP A 1 45  ? 17.35100  -14.03691 51.01746 1.000 71.59026  ? 45  ASP A C   1 
ATOM   351  O  O   . ASP A 1 45  ? 17.39234  -14.29077 49.81811 1.000 71.61378  ? 45  ASP A O   1 
ATOM   352  C  CB  . ASP A 1 45  ? 16.68073  -15.60351 52.87693 1.000 95.99735  ? 45  ASP A CB  1 
ATOM   353  C  CG  . ASP A 1 45  ? 17.13523  -16.62736 53.92016 1.000 105.41916 ? 45  ASP A CG  1 
ATOM   354  O  OD1 . ASP A 1 45  ? 18.06391  -17.41129 53.61401 1.000 106.78486 ? 45  ASP A OD1 1 
ATOM   355  O  OD2 . ASP A 1 45  ? 16.56901  -16.64737 55.04415 1.000 96.80359  ? 45  ASP A OD2 1 
ATOM   356  N  N   . ARG A 1 53  ? 21.02798  -14.92084 41.36998 1.000 64.57910  ? 53  ARG A N   1 
ATOM   357  C  CA  . ARG A 1 53  ? 22.12799  -15.62462 42.01769 1.000 84.75198  ? 53  ARG A CA  1 
ATOM   358  C  C   . ARG A 1 53  ? 22.03210  -15.42400 43.54288 1.000 80.99026  ? 53  ARG A C   1 
ATOM   359  O  O   . ARG A 1 53  ? 21.80487  -16.37780 44.28558 1.000 87.28863  ? 53  ARG A O   1 
ATOM   360  C  CB  . ARG A 1 53  ? 23.47769  -15.14706 41.43659 1.000 81.93229  ? 53  ARG A CB  1 
ATOM   361  C  CG  . ARG A 1 53  ? 24.75351  -15.71941 42.07058 1.000 73.07291  ? 53  ARG A CG  1 
ATOM   362  C  CD  . ARG A 1 53  ? 24.64832  -17.20514 42.41379 1.000 87.58936  ? 53  ARG A CD  1 
ATOM   363  N  NE  . ARG A 1 53  ? 24.73759  -18.07398 41.24677 1.000 95.16097  ? 53  ARG A NE  1 
ATOM   364  C  CZ  . ARG A 1 53  ? 24.58354  -19.39216 41.28294 1.000 99.45439  ? 53  ARG A CZ  1 
ATOM   365  N  NH1 . ARG A 1 53  ? 24.33377  -20.02964 42.41657 1.000 87.18955  ? 53  ARG A NH1 1 
ATOM   366  N  NH2 . ARG A 1 53  ? 24.67955  -20.08916 40.15312 1.000 106.64405 ? 53  ARG A NH2 1 
ATOM   367  N  N   . PHE A 1 54  ? 22.18338  -14.17818 43.99271 1.000 69.98980  ? 54  PHE A N   1 
ATOM   368  C  CA  . PHE A 1 54  ? 22.02509  -13.80674 45.39636 1.000 67.77622  ? 54  PHE A CA  1 
ATOM   369  C  C   . PHE A 1 54  ? 21.30055  -12.46921 45.47381 1.000 64.15842  ? 54  PHE A C   1 
ATOM   370  O  O   . PHE A 1 54  ? 21.64982  -11.52664 44.75701 1.000 53.56896  ? 54  PHE A O   1 
ATOM   371  C  CB  . PHE A 1 54  ? 23.38324  -13.71063 46.10849 1.000 68.50229  ? 54  PHE A CB  1 
ATOM   372  C  CG  . PHE A 1 54  ? 23.76664  -14.93992 46.88866 1.000 79.87739  ? 54  PHE A CG  1 
ATOM   373  C  CD1 . PHE A 1 54  ? 23.97957  -16.15919 46.25185 1.000 85.88219  ? 54  PHE A CD1 1 
ATOM   374  C  CD2 . PHE A 1 54  ? 23.95626  -14.86465 48.26611 1.000 88.41635  ? 54  PHE A CD2 1 
ATOM   375  C  CE1 . PHE A 1 54  ? 24.33856  -17.28793 46.98188 1.000 90.50664  ? 54  PHE A CE1 1 
ATOM   376  C  CE2 . PHE A 1 54  ? 24.31933  -15.98615 49.00068 1.000 86.34398  ? 54  PHE A CE2 1 
ATOM   377  C  CZ  . PHE A 1 54  ? 24.51136  -17.19942 48.35794 1.000 85.77522  ? 54  PHE A CZ  1 
ATOM   378  N  N   . ARG A 1 55  ? 20.28668  -12.39051 46.32967 1.000 56.97034  ? 55  ARG A N   1 
ATOM   379  C  CA  . ARG A 1 55  ? 19.53022  -11.15865 46.51443 1.000 55.53807  ? 55  ARG A CA  1 
ATOM   380  C  C   . ARG A 1 55  ? 19.19131  -11.01403 47.98770 1.000 50.87864  ? 55  ARG A C   1 
ATOM   381  O  O   . ARG A 1 55  ? 18.45561  -11.83258 48.54493 1.000 55.75769  ? 55  ARG A O   1 
ATOM   382  C  CB  . ARG A 1 55  ? 18.25633  -11.14590 45.66249 1.000 54.41604  ? 55  ARG A CB  1 
ATOM   383  C  CG  . ARG A 1 55  ? 17.24054  -10.10932 46.10793 1.000 65.58271  ? 55  ARG A CG  1 
ATOM   384  C  CD  . ARG A 1 55  ? 16.19098  -9.80857  45.03527 1.000 68.87579  ? 55  ARG A CD  1 
ATOM   385  N  NE  . ARG A 1 55  ? 16.59656  -8.69749  44.17679 1.000 72.11343  ? 55  ARG A NE  1 
ATOM   386  C  CZ  . ARG A 1 55  ? 15.77932  -8.03323  43.36596 1.000 73.78092  ? 55  ARG A CZ  1 
ATOM   387  N  NH1 . ARG A 1 55  ? 14.49451  -8.34285  43.27094 1.000 71.01490  ? 55  ARG A NH1 1 
ATOM   388  N  NH2 . ARG A 1 55  ? 16.26198  -7.02983  42.63358 1.000 67.56283  ? 55  ARG A NH2 1 
ATOM   389  N  N   . GLU A 1 56  ? 19.74217  -9.98917  48.61621 1.000 39.49934  ? 56  GLU A N   1 
ATOM   390  C  CA  . GLU A 1 56  ? 19.46446  -9.67521  50.00625 1.000 44.86299  ? 56  GLU A CA  1 
ATOM   391  C  C   . GLU A 1 56  ? 18.53788  -8.46761  50.05605 1.000 44.50568  ? 56  GLU A C   1 
ATOM   392  O  O   . GLU A 1 56  ? 18.71867  -7.50899  49.29414 1.000 33.18310  ? 56  GLU A O   1 
ATOM   393  C  CB  . GLU A 1 56  ? 20.77035  -9.39800  50.77424 1.000 41.47406  ? 56  GLU A CB  1 
ATOM   394  C  CG  . GLU A 1 56  ? 21.76266  -10.55517 50.72489 1.000 40.53371  ? 56  GLU A CG  1 
ATOM   395  C  CD  . GLU A 1 56  ? 23.03433  -10.30367 51.50065 1.000 43.50788  ? 56  GLU A CD  1 
ATOM   396  O  OE1 . GLU A 1 56  ? 23.27074  -9.14896  51.93012 1.000 48.09979  ? 56  GLU A OE1 1 
ATOM   397  O  OE2 . GLU A 1 56  ? 23.79745  -11.27574 51.69630 1.000 47.42022  ? 56  GLU A OE2 1 
ATOM   398  N  N   . ARG A 1 57  ? 17.54153  -8.50560  50.94236 1.000 45.58922  ? 57  ARG A N   1 
ATOM   399  C  CA  . ARG A 1 57  ? 16.57426  -7.42397  50.91482 1.000 36.34533  ? 57  ARG A CA  1 
ATOM   400  C  C   . ARG A 1 57  ? 15.98625  -7.14102  52.28294 1.000 35.16041  ? 57  ARG A C   1 
ATOM   401  O  O   . ARG A 1 57  ? 16.03462  -7.96819  53.19407 1.000 36.86146  ? 57  ARG A O   1 
ATOM   402  C  CB  . ARG A 1 57  ? 15.46107  -7.71127  49.92344 1.000 49.39223  ? 57  ARG A CB  1 
ATOM   403  C  CG  . ARG A 1 57  ? 14.91036  -9.09208  49.96623 1.000 53.26575  ? 57  ARG A CG  1 
ATOM   404  C  CD  . ARG A 1 57  ? 13.93305  -9.23318  48.82851 1.000 66.36025  ? 57  ARG A CD  1 
ATOM   405  N  NE  . ARG A 1 57  ? 12.92738  -8.18055  48.90737 1.000 75.94639  ? 57  ARG A NE  1 
ATOM   406  C  CZ  . ARG A 1 57  ? 12.03305  -7.92222  47.96388 1.000 70.83769  ? 57  ARG A CZ  1 
ATOM   407  N  NH1 . ARG A 1 57  ? 12.01201  -8.60165  46.82726 1.000 72.50527  ? 57  ARG A NH1 1 
ATOM   408  N  NH2 . ARG A 1 57  ? 11.14328  -6.95463  48.16401 1.000 61.45461  ? 57  ARG A NH2 1 
ATOM   409  N  N   . ALA A 1 58  ? 15.45351  -5.92369  52.41292 1.000 36.92513  ? 58  ALA A N   1 
ATOM   410  C  CA  . ALA A 1 58  ? 14.54972  -5.53957  53.49484 1.000 33.16155  ? 58  ALA A CA  1 
ATOM   411  C  C   . ALA A 1 58  ? 13.47675  -4.63650  52.90468 1.000 37.03422  ? 58  ALA A C   1 
ATOM   412  O  O   . ALA A 1 58  ? 13.63357  -4.09559  51.80356 1.000 37.02512  ? 58  ALA A O   1 
ATOM   413  C  CB  . ALA A 1 58  ? 15.27094  -4.84248  54.64194 1.000 23.71342  ? 58  ALA A CB  1 
ATOM   414  N  N   . TYR A 1 59  ? 12.38313  -4.46810  53.64307 1.000 30.91516  ? 59  TYR A N   1 
ATOM   415  C  CA  . TYR A 1 59  ? 11.20290  -3.85344  53.04866 1.000 33.79159  ? 59  TYR A CA  1 
ATOM   416  C  C   . TYR A 1 59  ? 10.29219  -3.30508  54.14109 1.000 32.18733  ? 59  TYR A C   1 
ATOM   417  O  O   . TYR A 1 59  ? 10.18480  -3.89492  55.20417 1.000 25.22165  ? 59  TYR A O   1 
ATOM   418  C  CB  . TYR A 1 59  ? 10.47387  -4.88445  52.19396 1.000 30.10718  ? 59  TYR A CB  1 
ATOM   419  C  CG  . TYR A 1 59  ? 9.08059   -4.54529  51.71225 1.000 33.36279  ? 59  TYR A CG  1 
ATOM   420  C  CD1 . TYR A 1 59  ? 7.95026   -4.90915  52.43596 1.000 33.88443  ? 59  TYR A CD1 1 
ATOM   421  C  CD2 . TYR A 1 59  ? 8.89752   -3.92738  50.48818 1.000 47.69872  ? 59  TYR A CD2 1 
ATOM   422  C  CE1 . TYR A 1 59  ? 6.67400   -4.61441  51.96067 1.000 35.27988  ? 59  TYR A CE1 1 
ATOM   423  C  CE2 . TYR A 1 59  ? 7.64111   -3.63581  50.00434 1.000 46.40098  ? 59  TYR A CE2 1 
ATOM   424  C  CZ  . TYR A 1 59  ? 6.53348   -3.98398  50.73382 1.000 44.89485  ? 59  TYR A CZ  1 
ATOM   425  O  OH  . TYR A 1 59  ? 5.30918   -3.67436  50.18843 1.000 45.52281  ? 59  TYR A OH  1 
ATOM   426  N  N   . ASP A 1 60  ? 9.62858   -2.18736  53.86352 1.000 33.67725  ? 60  ASP A N   1 
ATOM   427  C  CA  . ASP A 1 60  ? 8.53514   -1.72723  54.70870 1.000 28.23880  ? 60  ASP A CA  1 
ATOM   428  C  C   . ASP A 1 60  ? 7.65431   -0.78272  53.89324 1.000 31.56594  ? 60  ASP A C   1 
ATOM   429  O  O   . ASP A 1 60  ? 8.04410   -0.29261  52.83539 1.000 27.50790  ? 60  ASP A O   1 
ATOM   430  C  CB  . ASP A 1 60  ? 9.06553   -1.08617  56.00282 1.000 20.49842  ? 60  ASP A CB  1 
ATOM   431  C  CG  . ASP A 1 60  ? 9.19089   -2.10988  57.15911 1.000 23.13126  ? 60  ASP A CG  1 
ATOM   432  O  OD1 . ASP A 1 60  ? 8.21596   -2.85317  57.40146 1.000 26.48497  ? 60  ASP A OD1 1 
ATOM   433  O  OD2 . ASP A 1 60  ? 10.24620  -2.18949  57.82893 1.000 24.81309  ? 60  ASP A OD2 1 
ATOM   434  N  N   . ARG A 1 61  ? 6.43172   -0.57864  54.37188 1.000 26.36242  ? 61  ARG A N   1 
ATOM   435  C  CA  . ARG A 1 61  ? 5.47949   0.34087   53.77218 1.000 21.18899  ? 61  ARG A CA  1 
ATOM   436  C  C   . ARG A 1 61  ? 5.24551   1.50366   54.71669 1.000 38.50988  ? 61  ARG A C   1 
ATOM   437  O  O   . ARG A 1 61  ? 5.16348   1.32040   55.94473 1.000 30.91726  ? 61  ARG A O   1 
ATOM   438  C  CB  . ARG A 1 61  ? 4.13225   -0.33064  53.50497 1.000 39.77864  ? 61  ARG A CB  1 
ATOM   439  C  CG  . ARG A 1 61  ? 4.21884   -1.82290  53.26990 1.000 35.07537  ? 61  ARG A CG  1 
ATOM   440  C  CD  . ARG A 1 61  ? 3.64710   -2.14749  51.94615 1.000 31.55000  ? 61  ARG A CD  1 
ATOM   441  N  NE  . ARG A 1 61  ? 2.22359   -2.41831  51.97552 1.000 41.55847  ? 61  ARG A NE  1 
ATOM   442  C  CZ  . ARG A 1 61  ? 1.41482   -2.25678  50.93611 1.000 51.21739  ? 61  ARG A CZ  1 
ATOM   443  N  NH1 . ARG A 1 61  ? 1.84582   -1.73300  49.79839 1.000 49.73260  ? 61  ARG A NH1 1 
ATOM   444  N  NH2 . ARG A 1 61  ? 0.14406   -2.63468  51.03830 1.000 58.27753  ? 61  ARG A NH2 1 
ATOM   445  N  N   . PHE A 1 62  ? 5.10193   2.68976   54.14317 1.000 28.16033  ? 62  PHE A N   1 
ATOM   446  C  CA  . PHE A 1 62  ? 4.84640   3.88331   54.92631 1.000 26.58671  ? 62  PHE A CA  1 
ATOM   447  C  C   . PHE A 1 62  ? 3.53003   4.49237   54.48541 1.000 29.92319  ? 62  PHE A C   1 
ATOM   448  O  O   . PHE A 1 62  ? 3.20307   4.52179   53.29275 1.000 31.86742  ? 62  PHE A O   1 
ATOM   449  C  CB  . PHE A 1 62  ? 5.98063   4.90416   54.79923 1.000 21.78617  ? 62  PHE A CB  1 
ATOM   450  C  CG  . PHE A 1 62  ? 7.27518   4.42268   55.36376 1.000 23.98526  ? 62  PHE A CG  1 
ATOM   451  C  CD1 . PHE A 1 62  ? 8.19976   3.75103   54.55252 1.000 23.10297  ? 62  PHE A CD1 1 
ATOM   452  C  CD2 . PHE A 1 62  ? 7.57800   4.62547   56.71066 1.000 20.98661  ? 62  PHE A CD2 1 
ATOM   453  C  CE1 . PHE A 1 62  ? 9.41389   3.29843   55.07236 1.000 14.26274  ? 62  PHE A CE1 1 
ATOM   454  C  CE2 . PHE A 1 62  ? 8.79397   4.17536   57.25007 1.000 21.54304  ? 62  PHE A CE2 1 
ATOM   455  C  CZ  . PHE A 1 62  ? 9.70580   3.48591   56.41690 1.000 22.59312  ? 62  PHE A CZ  1 
ATOM   456  N  N   . PHE A 1 63  ? 2.75111   4.88931   55.47299 1.000 34.60681  ? 63  PHE A N   1 
ATOM   457  C  CA  . PHE A 1 63  ? 1.62584   5.78571   55.28666 1.000 33.51348  ? 63  PHE A CA  1 
ATOM   458  C  C   . PHE A 1 63  ? 2.18801   7.19253   55.12751 1.000 30.50536  ? 63  PHE A C   1 
ATOM   459  O  O   . PHE A 1 63  ? 3.02413   7.62030   55.92566 1.000 33.99958  ? 63  PHE A O   1 
ATOM   460  C  CB  . PHE A 1 63  ? 0.70754   5.66009   56.51276 1.000 31.47317  ? 63  PHE A CB  1 
ATOM   461  C  CG  . PHE A 1 63  ? -0.45565  6.59252   56.52609 1.000 31.97399  ? 63  PHE A CG  1 
ATOM   462  C  CD1 . PHE A 1 63  ? -0.31304  7.89912   56.97574 1.000 31.99464  ? 63  PHE A CD1 1 
ATOM   463  C  CD2 . PHE A 1 63  ? -1.71615  6.15099   56.12694 1.000 32.32506  ? 63  PHE A CD2 1 
ATOM   464  C  CE1 . PHE A 1 63  ? -1.41544  8.76272   57.01562 1.000 34.50448  ? 63  PHE A CE1 1 
ATOM   465  C  CE2 . PHE A 1 63  ? -2.80720  7.00817   56.16101 1.000 42.30805  ? 63  PHE A CE2 1 
ATOM   466  C  CZ  . PHE A 1 63  ? -2.64914  8.31280   56.61136 1.000 37.23178  ? 63  PHE A CZ  1 
ATOM   467  N  N   . PHE A 1 64  ? 1.74522   7.91446   54.10629 1.000 30.30661  ? 64  PHE A N   1 
ATOM   468  C  CA  . PHE A 1 64  ? 2.34376   9.20973   53.78967 1.000 30.96676  ? 64  PHE A CA  1 
ATOM   469  C  C   . PHE A 1 64  ? 1.26796   10.17095  53.31978 1.000 34.25554  ? 64  PHE A C   1 
ATOM   470  O  O   . PHE A 1 64  ? 0.51282   9.84919   52.39151 1.000 32.98806  ? 64  PHE A O   1 
ATOM   471  C  CB  . PHE A 1 64  ? 3.41456   9.03914   52.70824 1.000 28.89174  ? 64  PHE A CB  1 
ATOM   472  C  CG  . PHE A 1 64  ? 3.96349   10.32414  52.14318 1.000 30.37775  ? 64  PHE A CG  1 
ATOM   473  C  CD1 . PHE A 1 64  ? 4.50057   11.31172  52.96948 1.000 26.51779  ? 64  PHE A CD1 1 
ATOM   474  C  CD2 . PHE A 1 64  ? 4.04846   10.49294  50.76624 1.000 23.73722  ? 64  PHE A CD2 1 
ATOM   475  C  CE1 . PHE A 1 64  ? 5.05267   12.45497  52.42295 1.000 26.48061  ? 64  PHE A CE1 1 
ATOM   476  C  CE2 . PHE A 1 64  ? 4.60532   11.64345  50.20810 1.000 21.97133  ? 64  PHE A CE2 1 
ATOM   477  C  CZ  . PHE A 1 64  ? 5.10908   12.61718  51.02529 1.000 24.36209  ? 64  PHE A CZ  1 
ATOM   478  N  N   . VAL A 1 65  ? 1.20962   11.34244  53.93276 1.000 30.51639  ? 65  VAL A N   1 
ATOM   479  C  CA  . VAL A 1 65  ? 0.31218   12.41168  53.51181 1.000 34.15797  ? 65  VAL A CA  1 
ATOM   480  C  C   . VAL A 1 65  ? 1.15978   13.58906  53.04508 1.000 31.40016  ? 65  VAL A C   1 
ATOM   481  O  O   . VAL A 1 65  ? 1.71983   14.31882  53.87393 1.000 34.67243  ? 65  VAL A O   1 
ATOM   482  C  CB  . VAL A 1 65  ? -0.67292  12.81262  54.61678 1.000 34.89027  ? 65  VAL A CB  1 
ATOM   483  C  CG1 . VAL A 1 65  ? -1.61000  13.88475  54.09633 1.000 29.15437  ? 65  VAL A CG1 1 
ATOM   484  C  CG2 . VAL A 1 65  ? -1.46467  11.60994  55.09935 1.000 27.57669  ? 65  VAL A CG2 1 
ATOM   485  N  N   . PRO A 1 66  ? 1.27465   13.82139  51.74034 1.000 38.48625  ? 66  PRO A N   1 
ATOM   486  C  CA  . PRO A 1 66  ? 2.21716   14.83648  51.24781 1.000 32.85336  ? 66  PRO A CA  1 
ATOM   487  C  C   . PRO A 1 66  ? 1.98099   16.22672  51.81710 1.000 35.76566  ? 66  PRO A C   1 
ATOM   488  O  O   . PRO A 1 66  ? 2.96089   16.91180  52.12031 1.000 33.20335  ? 66  PRO A O   1 
ATOM   489  C  CB  . PRO A 1 66  ? 2.00814   14.79998  49.73017 1.000 32.42108  ? 66  PRO A CB  1 
ATOM   490  C  CG  . PRO A 1 66  ? 1.33977   13.48999  49.43632 1.000 35.73126  ? 66  PRO A CG  1 
ATOM   491  C  CD  . PRO A 1 66  ? 0.50279   13.19102  50.64877 1.000 36.98200  ? 66  PRO A CD  1 
ATOM   492  N  N   . ARG A 1 67  ? 0.72079   16.65761  51.98382 1.000 38.43318  ? 67  ARG A N   1 
ATOM   493  C  CA  . ARG A 1 67  ? 0.43534   18.01395  52.47213 1.000 37.28233  ? 67  ARG A CA  1 
ATOM   494  C  C   . ARG A 1 67  ? 1.10616   18.29244  53.81827 1.000 34.10389  ? 67  ARG A C   1 
ATOM   495  O  O   . ARG A 1 67  ? 1.76285   19.31989  53.99498 1.000 34.14661  ? 67  ARG A O   1 
ATOM   496  C  CB  . ARG A 1 67  ? -1.07866  18.22365  52.57844 1.000 40.73413  ? 67  ARG A CB  1 
ATOM   497  C  CG  . ARG A 1 67  ? -1.52809  19.65015  52.91022 1.000 43.95668  ? 67  ARG A CG  1 
ATOM   498  C  CD  . ARG A 1 67  ? -1.64537  20.55387  51.67926 1.000 51.71931  ? 67  ARG A CD  1 
ATOM   499  N  NE  . ARG A 1 67  ? -2.63046  20.05695  50.72345 1.000 52.94083  ? 67  ARG A NE  1 
ATOM   500  C  CZ  . ARG A 1 67  ? -2.88972  20.62308  49.55257 1.000 51.54423  ? 67  ARG A CZ  1 
ATOM   501  N  NH1 . ARG A 1 67  ? -2.25654  21.71829  49.16219 1.000 59.20451  ? 67  ARG A NH1 1 
ATOM   502  N  NH2 . ARG A 1 67  ? -3.80560  20.07652  48.75461 1.000 46.56005  ? 67  ARG A NH2 1 
ATOM   503  N  N   . THR A 1 68  ? 0.96325   17.38492  54.77964 1.000 35.72591  ? 68  THR A N   1 
ATOM   504  C  CA  . THR A 1 68  ? 1.51154   17.61685  56.10734 1.000 35.92893  ? 68  THR A CA  1 
ATOM   505  C  C   . THR A 1 68  ? 2.91824   17.05614  56.28731 1.000 41.85067  ? 68  THR A C   1 
ATOM   506  O  O   . THR A 1 68  ? 3.60958   17.44382  57.24318 1.000 36.19545  ? 68  THR A O   1 
ATOM   507  C  CB  . THR A 1 68  ? 0.56199   17.05383  57.17383 1.000 37.87228  ? 68  THR A CB  1 
ATOM   508  O  OG1 . THR A 1 68  ? 0.24094   15.68262  56.89026 1.000 46.33368  ? 68  THR A OG1 1 
ATOM   509  C  CG2 . THR A 1 68  ? -0.72045  17.84013  57.16413 1.000 36.47916  ? 68  THR A CG2 1 
ATOM   510  N  N   . GLY A 1 69  ? 3.38590   16.21503  55.36778 1.000 38.30634  ? 69  GLY A N   1 
ATOM   511  C  CA  . GLY A 1 69  ? 4.66234   15.55326  55.54690 1.000 31.66391  ? 69  GLY A CA  1 
ATOM   512  C  C   . GLY A 1 69  ? 4.61099   14.37442  56.49481 1.000 39.59805  ? 69  GLY A C   1 
ATOM   513  O  O   . GLY A 1 69  ? 5.66974   13.83155  56.85196 1.000 42.81435  ? 69  GLY A O   1 
ATOM   514  N  N   . GLU A 1 70  ? 3.41908   13.98428  56.93668 1.000 34.92452  ? 70  GLU A N   1 
ATOM   515  C  CA  . GLU A 1 70  ? 3.29303   12.89332  57.88760 1.000 35.77806  ? 70  GLU A CA  1 
ATOM   516  C  C   . GLU A 1 70  ? 3.74144   11.58292  57.25047 1.000 41.32699  ? 70  GLU A C   1 
ATOM   517  O  O   . GLU A 1 70  ? 3.30925   11.22997  56.14620 1.000 33.24268  ? 70  GLU A O   1 
ATOM   518  C  CB  . GLU A 1 70  ? 1.84186   12.79187  58.35696 1.000 23.59956  ? 70  GLU A CB  1 
ATOM   519  C  CG  . GLU A 1 70  ? 1.60026   11.70302  59.34468 1.000 31.76799  ? 70  GLU A CG  1 
ATOM   520  C  CD  . GLU A 1 70  ? 0.13662   11.48586  59.58517 1.000 39.54773  ? 70  GLU A CD  1 
ATOM   521  O  OE1 . GLU A 1 70  ? -0.67363  12.07170  58.83016 1.000 40.96691  ? 70  GLU A OE1 1 
ATOM   522  O  OE2 . GLU A 1 70  ? -0.21596  10.75212  60.54007 1.000 41.55957  ? 70  GLU A OE2 1 
ATOM   523  N  N   . VAL A 1 71  ? 4.62386   10.86994  57.94112 1.000 29.43436  ? 71  VAL A N   1 
ATOM   524  C  CA  . VAL A 1 71  ? 5.02416   9.53039   57.54457 1.000 33.37320  ? 71  VAL A CA  1 
ATOM   525  C  C   . VAL A 1 71  ? 4.80427   8.61557   58.74264 1.000 34.28866  ? 71  VAL A C   1 
ATOM   526  O  O   . VAL A 1 71  ? 5.37158   8.85400   59.81577 1.000 34.91486  ? 71  VAL A O   1 
ATOM   527  C  CB  . VAL A 1 71  ? 6.49265   9.47510   57.08881 1.000 31.07228  ? 71  VAL A CB  1 
ATOM   528  C  CG1 . VAL A 1 71  ? 6.81624   8.09209   56.53720 1.000 25.57724  ? 71  VAL A CG1 1 
ATOM   529  C  CG2 . VAL A 1 71  ? 6.79388   10.56429  56.06859 1.000 31.03396  ? 71  VAL A CG2 1 
ATOM   530  N  N   . ARG A 1 72  ? 4.02698   7.55120   58.55666 1.000 25.53175  ? 72  ARG A N   1 
ATOM   531  C  CA  . ARG A 1 72  ? 3.87284   6.54246   59.59150 1.000 31.57292  ? 72  ARG A CA  1 
ATOM   532  C  C   . ARG A 1 72  ? 4.36012   5.19425   59.08205 1.000 35.45399  ? 72  ARG A C   1 
ATOM   533  O  O   . ARG A 1 72  ? 4.05696   4.79589   57.95633 1.000 33.14509  ? 72  ARG A O   1 
ATOM   534  C  CB  . ARG A 1 72  ? 2.42174   6.43343   60.05053 1.000 32.86917  ? 72  ARG A CB  1 
ATOM   535  C  CG  . ARG A 1 72  ? 1.69064   7.77361   60.19683 1.000 30.12436  ? 72  ARG A CG  1 
ATOM   536  C  CD  . ARG A 1 72  ? 0.20803   7.55813   60.45647 1.000 38.98203  ? 72  ARG A CD  1 
ATOM   537  N  NE  . ARG A 1 72  ? 0.01200   6.56324   61.50432 1.000 50.91389  ? 72  ARG A NE  1 
ATOM   538  C  CZ  . ARG A 1 72  ? 0.16598   6.79484   62.80030 1.000 47.15471  ? 72  ARG A CZ  1 
ATOM   539  N  NH1 . ARG A 1 72  ? 0.43572   8.00703   63.25916 1.000 52.08163  ? 72  ARG A NH1 1 
ATOM   540  N  NH2 . ARG A 1 72  ? 0.05422   5.78333   63.65655 1.000 44.74779  ? 72  ARG A NH2 1 
ATOM   541  N  N   . LEU A 1 73  ? 5.09861   4.48167   59.91903 1.000 31.82907  ? 73  LEU A N   1 
ATOM   542  C  CA  . LEU A 1 73  ? 5.54237   3.14398   59.56326 1.000 28.36188  ? 73  LEU A CA  1 
ATOM   543  C  C   . LEU A 1 73  ? 4.37388   2.17142   59.71277 1.000 31.94529  ? 73  LEU A C   1 
ATOM   544  O  O   . LEU A 1 73  ? 3.88898   1.93877   60.83032 1.000 41.97184  ? 73  LEU A O   1 
ATOM   545  C  CB  . LEU A 1 73  ? 6.72910   2.72482   60.43332 1.000 31.74861  ? 73  LEU A CB  1 
ATOM   546  C  CG  . LEU A 1 73  ? 7.21229   1.27421   60.30022 1.000 31.72497  ? 73  LEU A CG  1 
ATOM   547  C  CD1 . LEU A 1 73  ? 7.69575   1.01227   58.85843 1.000 20.82727  ? 73  LEU A CD1 1 
ATOM   548  C  CD2 . LEU A 1 73  ? 8.29705   0.96346   61.33458 1.000 19.64352  ? 73  LEU A CD2 1 
ATOM   549  N  N   . ARG A 1 74  ? 3.91801   1.61221   58.58901 1.000 28.70668  ? 74  ARG A N   1 
ATOM   550  C  CA  . ARG A 1 74  ? 2.84003   0.63672   58.61289 1.000 35.96722  ? 74  ARG A CA  1 
ATOM   551  C  C   . ARG A 1 74  ? 3.33756   -0.66714  59.23488 1.000 29.71854  ? 74  ARG A C   1 
ATOM   552  O  O   . ARG A 1 74  ? 4.52243   -0.99339  59.13710 1.000 26.68730  ? 74  ARG A O   1 
ATOM   553  C  CB  . ARG A 1 74  ? 2.29778   0.37890   57.20218 1.000 31.09526  ? 74  ARG A CB  1 
ATOM   554  C  CG  . ARG A 1 74  ? 1.94277   1.62408   56.41712 1.000 31.16585  ? 74  ARG A CG  1 
ATOM   555  C  CD  . ARG A 1 74  ? 1.23708   1.29520   55.11254 1.000 32.56267  ? 74  ARG A CD  1 
ATOM   556  N  NE  . ARG A 1 74  ? -0.00113  0.55833   55.33679 1.000 43.39520  ? 74  ARG A NE  1 
ATOM   557  C  CZ  . ARG A 1 74  ? -0.70083  -0.05257  54.38514 1.000 54.19768  ? 74  ARG A CZ  1 
ATOM   558  N  NH1 . ARG A 1 74  ? -0.30316  -0.05011  53.11878 1.000 43.98364  ? 74  ARG A NH1 1 
ATOM   559  N  NH2 . ARG A 1 74  ? -1.82481  -0.68969  54.71261 1.000 36.25948  ? 74  ARG A NH2 1 
ATOM   560  N  N   . PRO A 1 75  ? 2.46301   -1.40625  59.92208 1.000 37.91824  ? 75  PRO A N   1 
ATOM   561  C  CA  . PRO A 1 75  ? 2.89635   -2.66757  60.54424 1.000 34.55298  ? 75  PRO A CA  1 
ATOM   562  C  C   . PRO A 1 75  ? 3.34953   -3.66627  59.48631 1.000 40.32322  ? 75  PRO A C   1 
ATOM   563  O  O   . PRO A 1 75  ? 2.76567   -3.76648  58.40768 1.000 34.42253  ? 75  PRO A O   1 
ATOM   564  C  CB  . PRO A 1 75  ? 1.63842   -3.15682  61.27873 1.000 31.79362  ? 75  PRO A CB  1 
ATOM   565  C  CG  . PRO A 1 75  ? 0.69994   -2.02502  61.31553 1.000 38.56819  ? 75  PRO A CG  1 
ATOM   566  C  CD  . PRO A 1 75  ? 1.03155   -1.13796  60.14746 1.000 43.92704  ? 75  PRO A CD  1 
ATOM   567  N  N   . HIS A 1 76  ? 4.37477   -4.43892  59.80837 1.000 33.01554  ? 76  HIS A N   1 
ATOM   568  C  CA  . HIS A 1 76  ? 4.90627   -5.37701  58.82659 1.000 32.52570  ? 76  HIS A CA  1 
ATOM   569  C  C   . HIS A 1 76  ? 4.02490   -6.63245  58.73176 1.000 37.61650  ? 76  HIS A C   1 
ATOM   570  O  O   . HIS A 1 76  ? 4.09070   -7.53371  59.58014 1.000 32.45637  ? 76  HIS A O   1 
ATOM   571  C  CB  . HIS A 1 76  ? 6.33945   -5.73043  59.17836 1.000 40.69930  ? 76  HIS A CB  1 
ATOM   572  C  CG  . HIS A 1 76  ? 7.00993   -6.51200  58.10721 1.000 47.24894  ? 76  HIS A CG  1 
ATOM   573  N  ND1 . HIS A 1 76  ? 7.78113   -7.61922  58.36708 1.000 56.75075  ? 76  HIS A ND1 1 
ATOM   574  C  CD2 . HIS A 1 76  ? 6.92098   -6.41471  56.75696 1.000 48.82602  ? 76  HIS A CD2 1 
ATOM   575  C  CE1 . HIS A 1 76  ? 8.19348   -8.12746  57.21399 1.000 55.67564  ? 76  HIS A CE1 1 
ATOM   576  N  NE2 . HIS A 1 76  ? 7.74157   -7.37616  56.22472 1.000 41.79564  ? 76  HIS A NE2 1 
ATOM   577  N  N   . ARG A 1 77  ? 3.20331   -6.69590  57.68938 1.000 35.83239  ? 77  ARG A N   1 
ATOM   578  C  CA  . ARG A 1 77  ? 2.31201   -7.82209  57.45121 1.000 43.26449  ? 77  ARG A CA  1 
ATOM   579  C  C   . ARG A 1 77  ? 3.09759   -9.12590  57.35551 1.000 35.37921  ? 77  ARG A C   1 
ATOM   580  O  O   . ARG A 1 77  ? 3.89257   -9.28895  56.43046 1.000 34.21667  ? 77  ARG A O   1 
ATOM   581  C  CB  . ARG A 1 77  ? 1.52842   -7.59432  56.16083 1.000 43.65770  ? 77  ARG A CB  1 
ATOM   582  C  CG  . ARG A 1 77  ? 0.44874   -8.63002  55.89206 1.000 48.06219  ? 77  ARG A CG  1 
ATOM   583  C  CD  . ARG A 1 77  ? -0.36789  -8.23303  54.68016 1.000 60.60751  ? 77  ARG A CD  1 
ATOM   584  N  NE  . ARG A 1 77  ? -1.42606  -9.20390  54.44488 1.000 65.51621  ? 77  ARG A NE  1 
ATOM   585  C  CZ  . ARG A 1 77  ? -2.65617  -9.09124  54.92096 1.000 67.08845  ? 77  ARG A CZ  1 
ATOM   586  N  NH1 . ARG A 1 77  ? -3.02710  -8.03796  55.63802 1.000 64.37195  ? 77  ARG A NH1 1 
ATOM   587  N  NH2 . ARG A 1 77  ? -3.53757  -10.05454 54.66623 1.000 70.71563  ? 77  ARG A NH2 1 
ATOM   588  N  N   . PRO A 1 78  ? 2.88523   -10.07580 58.25194 1.000 35.53857  ? 78  PRO A N   1 
ATOM   589  C  CA  . PRO A 1 78  ? 3.67486   -11.31104 58.19577 1.000 35.95324  ? 78  PRO A CA  1 
ATOM   590  C  C   . PRO A 1 78  ? 3.38721   -12.10743 56.93178 1.000 36.15733  ? 78  PRO A C   1 
ATOM   591  O  O   . PRO A 1 78  ? 2.25583   -12.14850 56.43403 1.000 24.34045  ? 78  PRO A O   1 
ATOM   592  C  CB  . PRO A 1 78  ? 3.23077   -12.07039 59.44825 1.000 39.01181  ? 78  PRO A CB  1 
ATOM   593  C  CG  . PRO A 1 78  ? 2.52075   -11.02648 60.32343 1.000 31.94234  ? 78  PRO A CG  1 
ATOM   594  C  CD  . PRO A 1 78  ? 1.89762   -10.09472 59.34697 1.000 39.26416  ? 78  PRO A CD  1 
ATOM   595  N  N   . TYR A 1 79  ? 4.43623   -12.76379 56.43050 1.000 34.10084  ? 79  TYR A N   1 
ATOM   596  C  CA  . TYR A 1 79  ? 4.30828   -13.57933 55.23205 1.000 31.98437  ? 79  TYR A CA  1 
ATOM   597  C  C   . TYR A 1 79  ? 3.28724   -14.69893 55.42319 1.000 40.40879  ? 79  TYR A C   1 
ATOM   598  O  O   . TYR A 1 79  ? 2.43489   -14.91965 54.55452 1.000 42.63426  ? 79  TYR A O   1 
ATOM   599  C  CB  . TYR A 1 79  ? 5.67614   -14.13611 54.83900 1.000 41.52600  ? 79  TYR A CB  1 
ATOM   600  C  CG  . TYR A 1 79  ? 5.66452   -14.85987 53.52098 1.000 56.18843  ? 79  TYR A CG  1 
ATOM   601  C  CD1 . TYR A 1 79  ? 5.46882   -14.16653 52.33317 1.000 59.08334  ? 79  TYR A CD1 1 
ATOM   602  C  CD2 . TYR A 1 79  ? 5.83546   -16.23950 53.45666 1.000 66.56758  ? 79  TYR A CD2 1 
ATOM   603  C  CE1 . TYR A 1 79  ? 5.43856   -14.82329 51.11447 1.000 61.37061  ? 79  TYR A CE1 1 
ATOM   604  C  CE2 . TYR A 1 79  ? 5.81382   -16.90377 52.23610 1.000 65.32506  ? 79  TYR A CE2 1 
ATOM   605  C  CZ  . TYR A 1 79  ? 5.61135   -16.18465 51.07329 1.000 63.99493  ? 79  TYR A CZ  1 
ATOM   606  O  OH  . TYR A 1 79  ? 5.58663   -16.82219 49.85657 1.000 79.97417  ? 79  TYR A OH  1 
ATOM   607  N  N   . PHE A 1 80  ? 3.33828   -15.40030 56.56842 1.000 35.78033  ? 80  PHE A N   1 
ATOM   608  C  CA  . PHE A 1 80  ? 2.35754   -16.45718 56.84083 1.000 39.20512  ? 80  PHE A CA  1 
ATOM   609  C  C   . PHE A 1 80  ? 0.92904   -15.94590 56.79208 1.000 32.97992  ? 80  PHE A C   1 
ATOM   610  O  O   . PHE A 1 80  ? 0.00915   -16.70661 56.50823 1.000 43.82552  ? 80  PHE A O   1 
ATOM   611  C  CB  . PHE A 1 80  ? 2.61098   -17.12749 58.19710 1.000 39.07473  ? 80  PHE A CB  1 
ATOM   612  C  CG  . PHE A 1 80  ? 2.33886   -16.25180 59.40918 1.000 31.92841  ? 80  PHE A CG  1 
ATOM   613  C  CD1 . PHE A 1 80  ? 1.05039   -16.04197 59.85962 1.000 34.03766  ? 80  PHE A CD1 1 
ATOM   614  C  CD2 . PHE A 1 80  ? 3.38883   -15.70817 60.13361 1.000 30.80387  ? 80  PHE A CD2 1 
ATOM   615  C  CE1 . PHE A 1 80  ? 0.80368   -15.27550 60.96211 1.000 32.97598  ? 80  PHE A CE1 1 
ATOM   616  C  CE2 . PHE A 1 80  ? 3.15662   -14.94646 61.24210 1.000 30.63854  ? 80  PHE A CE2 1 
ATOM   617  C  CZ  . PHE A 1 80  ? 1.86010   -14.72188 61.66199 1.000 35.74061  ? 80  PHE A CZ  1 
ATOM   618  N  N   . GLN A 1 81  ? 0.71265   -14.67074 57.06864 1.000 39.01287  ? 81  GLN A N   1 
ATOM   619  C  CA  . GLN A 1 81  ? -0.64286  -14.14616 57.00763 1.000 38.14950  ? 81  GLN A CA  1 
ATOM   620  C  C   . GLN A 1 81  ? -1.07017  -13.92006 55.56439 1.000 50.09168  ? 81  GLN A C   1 
ATOM   621  O  O   . GLN A 1 81  ? -2.16513  -14.32769 55.16437 1.000 46.15124  ? 81  GLN A O   1 
ATOM   622  C  CB  . GLN A 1 81  ? -0.73293  -12.84892 57.81090 1.000 36.70197  ? 81  GLN A CB  1 
ATOM   623  C  CG  . GLN A 1 81  ? -2.09040  -12.21646 57.80726 1.000 38.15143  ? 81  GLN A CG  1 
ATOM   624  C  CD  . GLN A 1 81  ? -2.05388  -10.89656 58.50605 1.000 42.08748  ? 81  GLN A CD  1 
ATOM   625  O  OE1 . GLN A 1 81  ? -1.35426  -10.74888 59.50085 1.000 44.83489  ? 81  GLN A OE1 1 
ATOM   626  N  NE2 . GLN A 1 81  ? -2.76923  -9.90949  57.97745 1.000 44.80000  ? 81  GLN A NE2 1 
ATOM   627  N  N   . SER A 1 82  ? -0.20340  -13.27978 54.76920 1.000 49.32131  ? 82  SER A N   1 
ATOM   628  C  CA  . SER A 1 82  ? -0.51595  -12.99242 53.37126 1.000 58.72821  ? 82  SER A CA  1 
ATOM   629  C  C   . SER A 1 82  ? -0.71883  -14.27342 52.57621 1.000 56.88929  ? 82  SER A C   1 
ATOM   630  O  O   . SER A 1 82  ? -1.71059  -14.42616 51.85322 1.000 61.87911  ? 82  SER A O   1 
ATOM   631  C  CB  . SER A 1 82  ? 0.60894   -12.16847 52.74512 1.000 54.04334  ? 82  SER A CB  1 
ATOM   632  O  OG  . SER A 1 82  ? 0.84579   -10.97445 53.45106 1.000 54.88373  ? 82  SER A OG  1 
ATOM   633  N  N   . MET A 1 83  ? 0.23162   -15.19726 52.68868 1.000 55.21740  ? 83  MET A N   1 
ATOM   634  C  CA  . MET A 1 83  ? 0.16924   -16.44256 51.93631 1.000 57.69482  ? 83  MET A CA  1 
ATOM   635  C  C   . MET A 1 83  ? -1.10076  -17.21737 52.25451 1.000 59.53287  ? 83  MET A C   1 
ATOM   636  O  O   . MET A 1 83  ? -1.84659  -17.61394 51.35176 1.000 67.84270  ? 83  MET A O   1 
ATOM   637  C  CB  . MET A 1 83  ? 1.40614   -17.27756 52.24815 1.000 61.50951  ? 83  MET A CB  1 
ATOM   638  C  CG  . MET A 1 83  ? 1.59067   -18.49679 51.36224 1.000 81.64636  ? 83  MET A CG  1 
ATOM   639  S  SD  . MET A 1 83  ? 3.26426   -19.15696 51.52439 1.000 96.41454  ? 83  MET A SD  1 
ATOM   640  C  CE  . MET A 1 83  ? 3.41240   -19.30548 53.31056 1.000 68.36212  ? 83  MET A CE  1 
ATOM   641  N  N   . ASN A 1 84  ? -1.37072  -17.43002 53.54007 1.000 56.12860  ? 84  ASN A N   1 
ATOM   642  C  CA  . ASN A 1 84  ? -2.52886  -18.21957 53.92797 1.000 48.14837  ? 84  ASN A CA  1 
ATOM   643  C  C   . ASN A 1 84  ? -3.84150  -17.49249 53.64780 1.000 50.36489  ? 84  ASN A C   1 
ATOM   644  O  O   . ASN A 1 84  ? -4.88276  -18.14280 53.50577 1.000 53.65611  ? 84  ASN A O   1 
ATOM   645  C  CB  . ASN A 1 84  ? -2.37848  -18.62556 55.40057 1.000 36.64624  ? 84  ASN A CB  1 
ATOM   646  C  CG  . ASN A 1 84  ? -1.35093  -19.76522 55.58566 1.000 42.02670  ? 84  ASN A CG  1 
ATOM   647  O  OD1 . ASN A 1 84  ? -1.60267  -20.90071 55.19805 1.000 46.42979  ? 84  ASN A OD1 1 
ATOM   648  N  ND2 . ASN A 1 84  ? -0.20127  -19.45795 56.16622 1.000 40.10000  ? 84  ASN A ND2 1 
ATOM   649  N  N   . ALA A 1 85  ? -3.81444  -16.16771 53.52796 1.000 52.22224  ? 85  ALA A N   1 
ATOM   650  C  CA  . ALA A 1 85  ? -5.00407  -15.42450 53.14333 1.000 49.05082  ? 85  ALA A CA  1 
ATOM   651  C  C   . ALA A 1 85  ? -5.17591  -15.31785 51.63572 1.000 62.06628  ? 85  ALA A C   1 
ATOM   652  O  O   . ALA A 1 85  ? -6.29041  -15.03379 51.17632 1.000 77.56773  ? 85  ALA A O   1 
ATOM   653  C  CB  . ALA A 1 85  ? -4.96630  -14.01358 53.74507 1.000 52.53313  ? 85  ALA A CB  1 
ATOM   654  N  N   . ASN A 1 86  ? -4.10799  -15.55053 50.86401 1.000 66.85482  ? 86  ASN A N   1 
ATOM   655  C  CA  . ASN A 1 86  ? -4.07336  -15.23522 49.42993 1.000 73.39750  ? 86  ASN A CA  1 
ATOM   656  C  C   . ASN A 1 86  ? -4.40775  -13.76206 49.19421 1.000 73.04494  ? 86  ASN A C   1 
ATOM   657  O  O   . ASN A 1 86  ? -5.13304  -13.40055 48.26397 1.000 80.52336  ? 86  ASN A O   1 
ATOM   658  C  CB  . ASN A 1 86  ? -5.00994  -16.14833 48.63415 1.000 80.79582  ? 86  ASN A CB  1 
ATOM   659  C  CG  . ASN A 1 86  ? -4.64480  -16.21309 47.16578 1.000 89.39148  ? 86  ASN A CG  1 
ATOM   660  O  OD1 . ASN A 1 86  ? -3.52371  -15.87492 46.78185 1.000 91.41041  ? 86  ASN A OD1 1 
ATOM   661  N  ND2 . ASN A 1 86  ? -5.58457  -16.65423 46.33677 1.000 90.26776  ? 86  ASN A ND2 1 
ATOM   662  N  N   . ASP A 1 87  ? -3.86925  -12.90406 50.06019 1.000 65.99925  ? 87  ASP A N   1 
ATOM   663  C  CA  . ASP A 1 87  ? -4.18460  -11.47714 50.06130 1.000 73.14789  ? 87  ASP A CA  1 
ATOM   664  C  C   . ASP A 1 87  ? -2.95087  -10.76285 50.60820 1.000 81.17688  ? 87  ASP A C   1 
ATOM   665  O  O   . ASP A 1 87  ? -2.71226  -10.77712 51.82321 1.000 79.98037  ? 87  ASP A O   1 
ATOM   666  C  CB  . ASP A 1 87  ? -5.42631  -11.18795 50.90061 1.000 63.64062  ? 87  ASP A CB  1 
ATOM   667  C  CG  . ASP A 1 87  ? -5.74829  -9.70464  50.98805 1.000 75.80371  ? 87  ASP A CG  1 
ATOM   668  O  OD1 . ASP A 1 87  ? -5.11401  -8.90109  50.26949 1.000 81.73167  ? 87  ASP A OD1 1 
ATOM   669  O  OD2 . ASP A 1 87  ? -6.64475  -9.34036  51.77559 1.000 78.40873  ? 87  ASP A OD2 1 
ATOM   670  N  N   . TYR A 1 88  ? -2.17695  -10.14647 49.71132 1.000 77.44392  ? 88  TYR A N   1 
ATOM   671  C  CA  . TYR A 1 88  ? -0.96020  -9.43333  50.08481 1.000 75.59023  ? 88  TYR A CA  1 
ATOM   672  C  C   . TYR A 1 88  ? -1.18389  -7.94003  50.31888 1.000 67.52892  ? 88  TYR A C   1 
ATOM   673  O  O   . TYR A 1 88  ? -0.20368  -7.19756  50.45410 1.000 62.94076  ? 88  TYR A O   1 
ATOM   674  C  CB  . TYR A 1 88  ? 0.11931   -9.64564  49.02137 1.000 73.98963  ? 88  TYR A CB  1 
ATOM   675  C  CG  . TYR A 1 88  ? 0.59243   -11.08025 48.94467 1.000 78.35837  ? 88  TYR A CG  1 
ATOM   676  C  CD1 . TYR A 1 88  ? -0.05365  -12.00094 48.12334 1.000 76.99679  ? 88  TYR A CD1 1 
ATOM   677  C  CD2 . TYR A 1 88  ? 1.67385   -11.52057 49.70752 1.000 67.51719  ? 88  TYR A CD2 1 
ATOM   678  C  CE1 . TYR A 1 88  ? 0.36336   -13.31485 48.05801 1.000 64.00961  ? 88  TYR A CE1 1 
ATOM   679  C  CE2 . TYR A 1 88  ? 2.10112   -12.84114 49.64977 1.000 68.50858  ? 88  TYR A CE2 1 
ATOM   680  C  CZ  . TYR A 1 88  ? 1.44188   -13.72894 48.81646 1.000 74.42885  ? 88  TYR A CZ  1 
ATOM   681  O  OH  . TYR A 1 88  ? 1.85435   -15.04126 48.74901 1.000 80.80222  ? 88  TYR A OH  1 
ATOM   682  N  N   . ALA A 1 89  ? -2.44470  -7.49294  50.34769 1.000 63.69069  ? 89  ALA A N   1 
ATOM   683  C  CA  . ALA A 1 89  ? -2.82915  -6.14947  50.79561 1.000 72.51840  ? 89  ALA A CA  1 
ATOM   684  C  C   . ALA A 1 89  ? -2.14319  -5.04168  49.99954 1.000 72.00148  ? 89  ALA A C   1 
ATOM   685  O  O   . ALA A 1 89  ? -1.88281  -3.95638  50.52807 1.000 69.21410  ? 89  ALA A O   1 
ATOM   686  C  CB  . ALA A 1 89  ? -2.56226  -5.97147  52.29349 1.000 60.26568  ? 89  ALA A CB  1 
ATOM   687  N  N   . GLY A 1 90  ? -1.86778  -5.29143  48.71919 1.000 63.99610  ? 90  GLY A N   1 
ATOM   688  C  CA  . GLY A 1 90  ? -1.13993  -4.35595  47.89623 1.000 55.23191  ? 90  GLY A CA  1 
ATOM   689  C  C   . GLY A 1 90  ? 0.36737   -4.52528  47.92162 1.000 64.72733  ? 90  GLY A C   1 
ATOM   690  O  O   . GLY A 1 90  ? 1.03544   -4.17121  46.93661 1.000 58.69757  ? 90  GLY A O   1 
ATOM   691  N  N   . GLY A 1 91  ? 0.92542   -5.06433  49.00904 1.000 68.74438  ? 91  GLY A N   1 
ATOM   692  C  CA  . GLY A 1 91  ? 2.36152   -5.20008  49.14971 1.000 61.18426  ? 91  GLY A CA  1 
ATOM   693  C  C   . GLY A 1 91  ? 2.94624   -6.30991  48.28770 1.000 65.87345  ? 91  GLY A C   1 
ATOM   694  O  O   . GLY A 1 91  ? 2.26762   -6.95464  47.48486 1.000 66.17145  ? 91  GLY A O   1 
ATOM   695  N  N   . ILE A 1 92  ? 4.25286   -6.52572  48.47132 1.000 57.54652  ? 92  ILE A N   1 
ATOM   696  C  CA  . ILE A 1 92  ? 4.96380   -7.56493  47.73111 1.000 67.71236  ? 92  ILE A CA  1 
ATOM   697  C  C   . ILE A 1 92  ? 4.51788   -8.94849  48.20073 1.000 69.78162  ? 92  ILE A C   1 
ATOM   698  O  O   . ILE A 1 92  ? 4.10037   -9.14203  49.35060 1.000 69.77720  ? 92  ILE A O   1 
ATOM   699  C  CB  . ILE A 1 92  ? 6.48541   -7.39369  47.89290 1.000 59.26661  ? 92  ILE A CB  1 
ATOM   700  C  CG1 . ILE A 1 92  ? 6.89242   -7.61937  49.34974 1.000 57.77295  ? 92  ILE A CG1 1 
ATOM   701  C  CG2 . ILE A 1 92  ? 6.91563   -6.01211  47.43284 1.000 52.14940  ? 92  ILE A CG2 1 
ATOM   702  C  CD1 . ILE A 1 92  ? 8.33370   -7.30007  49.62189 1.000 55.98093  ? 92  ILE A CD1 1 
ATOM   703  N  N   . ASP A 1 93  ? 4.60452   -9.92655  47.30084 1.000 75.25718  ? 93  ASP A N   1 
ATOM   704  C  CA  . ASP A 1 93  ? 4.22729   -11.30760 47.60897 1.000 79.54786  ? 93  ASP A CA  1 
ATOM   705  C  C   . ASP A 1 93  ? 5.43467   -12.18464 47.92313 1.000 77.84985  ? 93  ASP A C   1 
ATOM   706  O  O   . ASP A 1 93  ? 5.48033   -13.36224 47.55314 1.000 72.68396  ? 93  ASP A O   1 
ATOM   707  C  CB  . ASP A 1 93  ? 3.39378   -11.91275 46.47927 1.000 78.49920  ? 93  ASP A CB  1 
ATOM   708  C  CG  . ASP A 1 93  ? 3.89354   -11.52822 45.09730 1.000 88.01170  ? 93  ASP A CG  1 
ATOM   709  O  OD1 . ASP A 1 93  ? 5.06937   -11.10803 44.97525 1.000 94.04889  ? 93  ASP A OD1 1 
ATOM   710  O  OD2 . ASP A 1 93  ? 3.09358   -11.64005 44.13612 1.000 73.19613  ? 93  ASP A OD2 1 
ATOM   711  N  N   . ARG A 1 94  ? 6.41543   -11.63226 48.63508 1.000 74.87032  ? 94  ARG A N   1 
ATOM   712  C  CA  . ARG A 1 94  ? 7.60239   -12.36133 49.04462 1.000 64.61283  ? 94  ARG A CA  1 
ATOM   713  C  C   . ARG A 1 94  ? 7.81292   -12.21303 50.54752 1.000 65.58428  ? 94  ARG A C   1 
ATOM   714  O  O   . ARG A 1 94  ? 7.22355   -11.34937 51.21505 1.000 55.83929  ? 94  ARG A O   1 
ATOM   715  C  CB  . ARG A 1 94  ? 8.84334   -11.88231 48.27484 1.000 64.64326  ? 94  ARG A CB  1 
ATOM   716  C  CG  . ARG A 1 94  ? 9.19005   -12.77736 47.09036 1.000 85.13704  ? 94  ARG A CG  1 
ATOM   717  C  CD  . ARG A 1 94  ? 8.38857   -12.42460 45.84256 1.000 91.83409  ? 94  ARG A CD  1 
ATOM   718  N  NE  . ARG A 1 94  ? 8.79044   -11.13027 45.29942 1.000 101.83403 ? 94  ARG A NE  1 
ATOM   719  C  CZ  . ARG A 1 94  ? 9.84507   -10.93685 44.51543 1.000 101.84986 ? 94  ARG A CZ  1 
ATOM   720  N  NH1 . ARG A 1 94  ? 10.63379  -11.93810 44.15504 1.000 97.84886  ? 94  ARG A NH1 1 
ATOM   721  N  NH2 . ARG A 1 94  ? 10.11725  -9.70757  44.08352 1.000 92.48537  ? 94  ARG A NH2 1 
ATOM   722  N  N   . ASP A 1 95  ? 8.66445   -13.08736 51.07402 1.000 53.88389  ? 95  ASP A N   1 
ATOM   723  C  CA  . ASP A 1 95  ? 9.00261   -13.09819 52.49039 1.000 53.94737  ? 95  ASP A CA  1 
ATOM   724  C  C   . ASP A 1 95  ? 10.25285  -12.25074 52.67500 1.000 53.65049  ? 95  ASP A C   1 
ATOM   725  O  O   . ASP A 1 95  ? 11.35283  -12.67276 52.30504 1.000 58.59513  ? 95  ASP A O   1 
ATOM   726  C  CB  . ASP A 1 95  ? 9.22571   -14.52678 52.98111 1.000 39.21000  ? 95  ASP A CB  1 
ATOM   727  C  CG  . ASP A 1 95  ? 9.66196   -14.58586 54.43479 1.000 62.36221  ? 95  ASP A CG  1 
ATOM   728  O  OD1 . ASP A 1 95  ? 9.41058   -13.62470 55.20543 1.000 55.94797  ? 95  ASP A OD1 1 
ATOM   729  O  OD2 . ASP A 1 95  ? 10.26853  -15.60834 54.81400 1.000 70.16205  ? 95  ASP A OD2 1 
ATOM   730  N  N   . VAL A 1 96  ? 10.08989  -11.05690 53.24443 1.000 47.42618  ? 96  VAL A N   1 
ATOM   731  C  CA  . VAL A 1 96  ? 11.18563  -10.11097 53.40159 1.000 42.98705  ? 96  VAL A CA  1 
ATOM   732  C  C   . VAL A 1 96  ? 11.23179  -9.60216  54.83805 1.000 32.95927  ? 96  VAL A C   1 
ATOM   733  O  O   . VAL A 1 96  ? 10.19221  -9.38147  55.46381 1.000 41.28031  ? 96  VAL A O   1 
ATOM   734  C  CB  . VAL A 1 96  ? 11.05223  -8.94037  52.41048 1.000 36.88046  ? 96  VAL A CB  1 
ATOM   735  C  CG1 . VAL A 1 96  ? 12.31101  -8.09490  52.44398 1.000 43.25284  ? 96  VAL A CG1 1 
ATOM   736  C  CG2 . VAL A 1 96  ? 10.81745  -9.46095  51.01994 1.000 54.93724  ? 96  VAL A CG2 1 
ATOM   737  N  N   . ALA A 1 97  ? 12.44032  -9.37690  55.33525 1.000 28.33276  ? 97  ALA A N   1 
ATOM   738  C  CA  . ALA A 1 97  ? 12.66019  -8.85680  56.66239 1.000 31.79092  ? 97  ALA A CA  1 
ATOM   739  C  C   . ALA A 1 97  ? 12.32945  -7.36594  56.70975 1.000 42.86703  ? 97  ALA A C   1 
ATOM   740  O  O   . ALA A 1 97  ? 12.24471  -6.70274  55.67000 1.000 35.17439  ? 97  ALA A O   1 
ATOM   741  C  CB  . ALA A 1 97  ? 14.11237  -9.09688  57.07826 1.000 37.86453  ? 97  ALA A CB  1 
ATOM   742  N  N   . PRO A 1 98  ? 12.10501  -6.82984  57.90867 1.000 40.39492  ? 98  PRO A N   1 
ATOM   743  C  CA  . PRO A 1 98  ? 11.82949  -5.39683  58.06258 1.000 37.63921  ? 98  PRO A CA  1 
ATOM   744  C  C   . PRO A 1 98  ? 13.08427  -4.56210  57.85202 1.000 33.38874  ? 98  PRO A C   1 
ATOM   745  O  O   . PRO A 1 98  ? 14.21348  -5.05491  57.93384 1.000 34.10854  ? 98  PRO A O   1 
ATOM   746  C  CB  . PRO A 1 98  ? 11.37180  -5.27802  59.52364 1.000 37.99739  ? 98  PRO A CB  1 
ATOM   747  C  CG  . PRO A 1 98  ? 10.98806  -6.67358  59.92039 1.000 43.79199  ? 98  PRO A CG  1 
ATOM   748  C  CD  . PRO A 1 98  ? 11.93382  -7.55817  59.17544 1.000 36.38344  ? 98  PRO A CD  1 
ATOM   749  N  N   . LEU A 1 99  ? 12.86839  -3.26458  57.63042 1.000 25.50567  ? 99  LEU A N   1 
ATOM   750  C  CA  . LEU A 1 99  ? 13.98114  -2.31651  57.71176 1.000 32.14906  ? 99  LEU A CA  1 
ATOM   751  C  C   . LEU A 1 99  ? 14.57471  -2.31339  59.12880 1.000 26.33150  ? 99  LEU A C   1 
ATOM   752  O  O   . LEU A 1 99  ? 13.86210  -2.41846  60.13217 1.000 35.17584  ? 99  LEU A O   1 
ATOM   753  C  CB  . LEU A 1 99  ? 13.52086  -0.90857  57.31140 1.000 24.91332  ? 99  LEU A CB  1 
ATOM   754  C  CG  . LEU A 1 99  ? 12.89262  -0.67995  55.92734 1.000 32.73000  ? 99  LEU A CG  1 
ATOM   755  C  CD1 . LEU A 1 99  ? 12.40148  0.75174   55.78279 1.000 29.82635  ? 99  LEU A CD1 1 
ATOM   756  C  CD2 . LEU A 1 99  ? 13.85956  -1.01915  54.77624 1.000 29.72597  ? 99  LEU A CD2 1 
ATOM   757  N  N   . SER A 1 100 ? 15.89175  -2.20745  59.21130 1.000 29.55123  ? 100 SER A N   1 
ATOM   758  C  CA  . SER A 1 100 ? 16.53705  -2.23675  60.51331 1.000 28.72377  ? 100 SER A CA  1 
ATOM   759  C  C   . SER A 1 100 ? 16.15519  -0.99556  61.31125 1.000 37.88738  ? 100 SER A C   1 
ATOM   760  O  O   . SER A 1 100 ? 15.64363  -0.01959  60.76622 1.000 42.83586  ? 100 SER A O   1 
ATOM   761  C  CB  . SER A 1 100 ? 18.05352  -2.32973  60.36847 1.000 26.31700  ? 100 SER A CB  1 
ATOM   762  O  OG  . SER A 1 100 ? 18.62190  -1.09035  59.96458 1.000 28.23897  ? 100 SER A OG  1 
ATOM   763  N  N   . ARG A 1 101 ? 16.40367  -1.04343  62.62926 1.000 40.95071  ? 101 ARG A N   1 
ATOM   764  C  CA  . ARG A 1 101 ? 16.09510  0.10432   63.47665 1.000 44.51153  ? 101 ARG A CA  1 
ATOM   765  C  C   . ARG A 1 101 ? 16.99558  1.28209   63.15611 1.000 39.43238  ? 101 ARG A C   1 
ATOM   766  O  O   . ARG A 1 101 ? 16.57052  2.43316   63.28917 1.000 39.78572  ? 101 ARG A O   1 
ATOM   767  C  CB  . ARG A 1 101 ? 16.21503  -0.25186  64.97051 1.000 45.87664  ? 101 ARG A CB  1 
ATOM   768  C  CG  . ARG A 1 101 ? 17.55609  0.10149   65.60376 1.000 50.11281  ? 101 ARG A CG  1 
ATOM   769  C  CD  . ARG A 1 101 ? 17.57214  -0.11570  67.10629 1.000 58.49248  ? 101 ARG A CD  1 
ATOM   770  N  NE  . ARG A 1 101 ? 16.51225  0.63550   67.76684 1.000 57.80824  ? 101 ARG A NE  1 
ATOM   771  C  CZ  . ARG A 1 101 ? 16.48229  0.91850   69.06107 1.000 52.39212  ? 101 ARG A CZ  1 
ATOM   772  N  NH1 . ARG A 1 101 ? 17.44463  0.52641   69.87915 1.000 61.13378  ? 101 ARG A NH1 1 
ATOM   773  N  NH2 . ARG A 1 101 ? 15.45987  1.61327   69.54715 1.000 60.86456  ? 101 ARG A NH2 1 
ATOM   774  N  N   . THR A 1 102 ? 18.23660  1.02912   62.74268 1.000 30.61938  ? 102 THR A N   1 
ATOM   775  C  CA  . THR A 1 102 ? 19.09957  2.15079   62.40459 1.000 32.09258  ? 102 THR A CA  1 
ATOM   776  C  C   . THR A 1 102 ? 18.86413  2.66330   60.98736 1.000 38.10214  ? 102 THR A C   1 
ATOM   777  O  O   . THR A 1 102 ? 19.30072  3.77811   60.66204 1.000 32.86388  ? 102 THR A O   1 
ATOM   778  C  CB  . THR A 1 102 ? 20.55858  1.77047   62.60153 1.000 33.50595  ? 102 THR A CB  1 
ATOM   779  O  OG1 . THR A 1 102 ? 20.88106  0.69986   61.72253 1.000 32.58422  ? 102 THR A OG1 1 
ATOM   780  C  CG2 . THR A 1 102 ? 20.78048  1.32090   64.04154 1.000 28.78812  ? 102 THR A CG2 1 
ATOM   781  N  N   . THR A 1 103 ? 18.17225  1.89346   60.14461 1.000 31.17563  ? 103 THR A N   1 
ATOM   782  C  CA  . THR A 1 103 ? 17.63332  2.48930   58.93129 1.000 31.53664  ? 103 THR A CA  1 
ATOM   783  C  C   . THR A 1 103 ? 16.51161  3.45926   59.27503 1.000 28.54644  ? 103 THR A C   1 
ATOM   784  O  O   . THR A 1 103 ? 16.51559  4.60619   58.82566 1.000 27.78411  ? 103 THR A O   1 
ATOM   785  C  CB  . THR A 1 103 ? 17.15288  1.40517   57.96534 1.000 28.82144  ? 103 THR A CB  1 
ATOM   786  O  OG1 . THR A 1 103 ? 18.28011  0.68350   57.46450 1.000 27.66232  ? 103 THR A OG1 1 
ATOM   787  C  CG2 . THR A 1 103 ? 16.42644  2.02101   56.79906 1.000 28.65213  ? 103 THR A CG2 1 
ATOM   788  N  N   . LEU A 1 104 ? 15.55697  3.02022   60.10271 1.000 36.10172  ? 104 LEU A N   1 
ATOM   789  C  CA  . LEU A 1 104 ? 14.40318  3.84514   60.45023 1.000 31.92980  ? 104 LEU A CA  1 
ATOM   790  C  C   . LEU A 1 104 ? 14.79410  5.07903   61.24722 1.000 30.54987  ? 104 LEU A C   1 
ATOM   791  O  O   . LEU A 1 104 ? 14.12206  6.11042   61.14594 1.000 36.15794  ? 104 LEU A O   1 
ATOM   792  C  CB  . LEU A 1 104 ? 13.38219  3.01890   61.23413 1.000 33.63335  ? 104 LEU A CB  1 
ATOM   793  C  CG  . LEU A 1 104 ? 12.79240  1.89946   60.37640 1.000 32.73760  ? 104 LEU A CG  1 
ATOM   794  C  CD1 . LEU A 1 104 ? 12.00227  0.89792   61.19157 1.000 26.12065  ? 104 LEU A CD1 1 
ATOM   795  C  CD2 . LEU A 1 104 ? 11.96623  2.48087   59.22483 1.000 27.59238  ? 104 LEU A CD2 1 
ATOM   796  N  N   . ALA A 1 105 ? 15.85741  5.00063   62.03950 1.000 24.83721  ? 105 ALA A N   1 
ATOM   797  C  CA  . ALA A 1 105 ? 16.25659  6.14811   62.84295 1.000 29.80580  ? 105 ALA A CA  1 
ATOM   798  C  C   . ALA A 1 105 ? 17.05287  7.16718   62.04216 1.000 35.39209  ? 105 ALA A C   1 
ATOM   799  O  O   . ALA A 1 105 ? 17.21262  8.30739   62.49419 1.000 32.62394  ? 105 ALA A O   1 
ATOM   800  C  CB  . ALA A 1 105 ? 17.09013  5.69939   64.04153 1.000 20.44962  ? 105 ALA A CB  1 
ATOM   801  N  N   . ASN A 1 106 ? 17.56316  6.78388   60.88422 1.000 27.55584  ? 106 ASN A N   1 
ATOM   802  C  CA  . ASN A 1 106 ? 18.29895  7.72637   60.06697 1.000 29.61337  ? 106 ASN A CA  1 
ATOM   803  C  C   . ASN A 1 106 ? 17.31963  8.75022   59.51796 1.000 28.09406  ? 106 ASN A C   1 
ATOM   804  O  O   . ASN A 1 106 ? 16.35860  8.37107   58.84166 1.000 35.39514  ? 106 ASN A O   1 
ATOM   805  C  CB  . ASN A 1 106 ? 19.01338  7.01207   58.93190 1.000 24.77704  ? 106 ASN A CB  1 
ATOM   806  C  CG  . ASN A 1 106 ? 19.98675  7.91676   58.19437 1.000 28.99172  ? 106 ASN A CG  1 
ATOM   807  O  OD1 . ASN A 1 106 ? 19.78907  9.12549   58.11725 1.000 30.72266  ? 106 ASN A OD1 1 
ATOM   808  N  ND2 . ASN A 1 106 ? 21.04259  7.32740   57.63778 1.000 27.35627  ? 106 ASN A ND2 1 
ATOM   809  N  N   . PRO A 1 107 ? 17.49059  10.03398  59.80401 1.000 35.26553  ? 107 PRO A N   1 
ATOM   810  C  CA  . PRO A 1 107 ? 16.57858  11.03972  59.22687 1.000 39.66506  ? 107 PRO A CA  1 
ATOM   811  C  C   . PRO A 1 107 ? 16.64391  11.14657  57.69898 1.000 29.42934  ? 107 PRO A C   1 
ATOM   812  O  O   . PRO A 1 107 ? 15.68240  11.63746  57.08524 1.000 26.59220  ? 107 PRO A O   1 
ATOM   813  C  CB  . PRO A 1 107 ? 17.04180  12.33752  59.89727 1.000 32.70198  ? 107 PRO A CB  1 
ATOM   814  C  CG  . PRO A 1 107 ? 18.48579  12.07082  60.22977 1.000 34.80558  ? 107 PRO A CG  1 
ATOM   815  C  CD  . PRO A 1 107 ? 18.49520  10.64543  60.68389 1.000 25.94061  ? 107 PRO A CD  1 
ATOM   816  N  N   . LEU A 1 108 ? 17.74586  10.71708  57.07392 1.000 24.62035  ? 108 LEU A N   1 
ATOM   817  C  CA  . LEU A 1 108 ? 17.81809  10.72144  55.61898 1.000 24.97996  ? 108 LEU A CA  1 
ATOM   818  C  C   . LEU A 1 108 ? 16.69971  9.89995   54.98620 1.000 30.81184  ? 108 LEU A C   1 
ATOM   819  O  O   . LEU A 1 108 ? 16.24733  10.22484  53.88077 1.000 36.13466  ? 108 LEU A O   1 
ATOM   820  C  CB  . LEU A 1 108 ? 19.16518  10.19277  55.14562 1.000 27.67783  ? 108 LEU A CB  1 
ATOM   821  C  CG  . LEU A 1 108 ? 19.36174  10.22550  53.62769 1.000 21.75104  ? 108 LEU A CG  1 
ATOM   822  C  CD1 . LEU A 1 108 ? 19.21938  11.63155  53.08549 1.000 16.27184  ? 108 LEU A CD1 1 
ATOM   823  C  CD2 . LEU A 1 108 ? 20.71995  9.64200   53.24729 1.000 27.78809  ? 108 LEU A CD2 1 
ATOM   824  N  N   . LEU A 1 109 ? 16.23697  8.83900   55.65557 1.000 30.36561  ? 109 LEU A N   1 
ATOM   825  C  CA  . LEU A 1 109 ? 15.16622  8.03377   55.07601 1.000 22.02904  ? 109 LEU A CA  1 
ATOM   826  C  C   . LEU A 1 109 ? 13.88965  8.85142   54.96823 1.000 24.91775  ? 109 LEU A C   1 
ATOM   827  O  O   . LEU A 1 109 ? 13.30149  8.96589   53.88291 1.000 22.47660  ? 109 LEU A O   1 
ATOM   828  C  CB  . LEU A 1 109 ? 14.93422  6.76978   55.89953 1.000 24.21707  ? 109 LEU A CB  1 
ATOM   829  C  CG  . LEU A 1 109 ? 13.89434  5.80902   55.30637 1.000 31.44756  ? 109 LEU A CG  1 
ATOM   830  C  CD1 . LEU A 1 109 ? 14.46905  5.07131   54.09044 1.000 33.33561  ? 109 LEU A CD1 1 
ATOM   831  C  CD2 . LEU A 1 109 ? 13.37478  4.82482   56.33023 1.000 22.14686  ? 109 LEU A CD2 1 
ATOM   832  N  N   . THR A 1 110 ? 13.49778  9.50177   56.06435 1.000 24.76126  ? 110 THR A N   1 
ATOM   833  C  CA  . THR A 1 110 ? 12.30626  10.34653  56.03897 1.000 28.67277  ? 110 THR A CA  1 
ATOM   834  C  C   . THR A 1 110 ? 12.46751  11.49289  55.04703 1.000 28.16240  ? 110 THR A C   1 
ATOM   835  O  O   . THR A 1 110 ? 11.53166  11.81422  54.30329 1.000 30.59039  ? 110 THR A O   1 
ATOM   836  C  CB  . THR A 1 110 ? 12.02225  10.88062  57.44582 1.000 35.75161  ? 110 THR A CB  1 
ATOM   837  O  OG1 . THR A 1 110 ? 11.63299  9.79666   58.30219 1.000 31.82613  ? 110 THR A OG1 1 
ATOM   838  C  CG2 . THR A 1 110 ? 10.91751  11.91391  57.41255 1.000 30.67423  ? 110 THR A CG2 1 
ATOM   839  N  N   . ARG A 1 111 ? 13.66791  12.08489  54.99313 1.000 28.75611  ? 111 ARG A N   1 
ATOM   840  C  CA  . ARG A 1 111 ? 13.94321  13.18992  54.07955 1.000 27.07757  ? 111 ARG A CA  1 
ATOM   841  C  C   . ARG A 1 111 ? 13.80725  12.76971  52.62108 1.000 29.71179  ? 111 ARG A C   1 
ATOM   842  O  O   . ARG A 1 111 ? 13.14274  13.44807  51.83197 1.000 24.99113  ? 111 ARG A O   1 
ATOM   843  C  CB  . ARG A 1 111 ? 15.34263  13.73915  54.33012 1.000 27.29705  ? 111 ARG A CB  1 
ATOM   844  C  CG  . ARG A 1 111 ? 15.83797  14.58528  53.16897 1.000 46.09174  ? 111 ARG A CG  1 
ATOM   845  C  CD  . ARG A 1 111 ? 17.06759  15.43343  53.51702 1.000 46.92341  ? 111 ARG A CD  1 
ATOM   846  N  NE  . ARG A 1 111 ? 16.70473  16.61533  54.28934 1.000 68.21043  ? 111 ARG A NE  1 
ATOM   847  C  CZ  . ARG A 1 111 ? 17.52018  17.63425  54.52097 1.000 73.00249  ? 111 ARG A CZ  1 
ATOM   848  N  NH1 . ARG A 1 111 ? 18.75581  17.65183  54.03813 1.000 66.19362  ? 111 ARG A NH1 1 
ATOM   849  N  NH2 . ARG A 1 111 ? 17.08420  18.66075  55.25186 1.000 62.19021  ? 111 ARG A NH2 1 
ATOM   850  N  N   . LEU A 1 112 ? 14.46311  11.66196  52.24143 1.000 28.34964  ? 112 LEU A N   1 
ATOM   851  C  CA  . LEU A 1 112 ? 14.33474  11.13986  50.88707 1.000 23.50655  ? 112 LEU A CA  1 
ATOM   852  C  C   . LEU A 1 112 ? 12.87914  10.88073  50.54028 1.000 26.55867  ? 112 LEU A C   1 
ATOM   853  O  O   . LEU A 1 112 ? 12.39907  11.29107  49.47673 1.000 29.40050  ? 112 LEU A O   1 
ATOM   854  C  CB  . LEU A 1 112 ? 15.15702  9.85781   50.73187 1.000 23.37267  ? 112 LEU A CB  1 
ATOM   855  C  CG  . LEU A 1 112 ? 16.65894  10.10683  50.69711 1.000 24.31625  ? 112 LEU A CG  1 
ATOM   856  C  CD1 . LEU A 1 112 ? 17.44136  8.86076   50.29873 1.000 23.52736  ? 112 LEU A CD1 1 
ATOM   857  C  CD2 . LEU A 1 112 ? 16.90792  11.22721  49.71218 1.000 33.68384  ? 112 LEU A CD2 1 
ATOM   858  N  N   . LEU A 1 113 ? 12.15565  10.21880  51.43823 1.000 24.57234  ? 113 LEU A N   1 
ATOM   859  C  CA  . LEU A 1 113 ? 10.76752  9.89096   51.17072 1.000 24.15862  ? 113 LEU A CA  1 
ATOM   860  C  C   . LEU A 1 113 ? 9.95186   11.14401  50.89132 1.000 30.15989  ? 113 LEU A C   1 
ATOM   861  O  O   . LEU A 1 113 ? 9.15547   11.17066  49.94537 1.000 30.49733  ? 113 LEU A O   1 
ATOM   862  C  CB  . LEU A 1 113 ? 10.19698  9.10008   52.34783 1.000 26.76577  ? 113 LEU A CB  1 
ATOM   863  C  CG  . LEU A 1 113 ? 8.80449   8.53927   52.12058 1.000 33.94019  ? 113 LEU A CG  1 
ATOM   864  C  CD1 . LEU A 1 113 ? 8.67255   7.18807   52.82650 1.000 27.33212  ? 113 LEU A CD1 1 
ATOM   865  C  CD2 . LEU A 1 113 ? 7.71365   9.52916   52.59306 1.000 25.84748  ? 113 LEU A CD2 1 
ATOM   866  N  N   . ARG A 1 114 ? 10.15281  12.20076  51.68472 1.000 27.93332  ? 114 ARG A N   1 
ATOM   867  C  CA  . ARG A 1 114 ? 9.40653   13.43313  51.46176 1.000 29.47209  ? 114 ARG A CA  1 
ATOM   868  C  C   . ARG A 1 114 ? 9.91181   14.19438  50.24036 1.000 24.26533  ? 114 ARG A C   1 
ATOM   869  O  O   . ARG A 1 114 ? 9.11652   14.66527  49.42072 1.000 27.92892  ? 114 ARG A O   1 
ATOM   870  C  CB  . ARG A 1 114 ? 9.48672   14.33810  52.69279 1.000 29.95807  ? 114 ARG A CB  1 
ATOM   871  C  CG  . ARG A 1 114 ? 8.76410   13.82254  53.90612 1.000 30.24338  ? 114 ARG A CG  1 
ATOM   872  C  CD  . ARG A 1 114 ? 8.96207   14.80977  55.03127 1.000 32.28485  ? 114 ARG A CD  1 
ATOM   873  N  NE  . ARG A 1 114 ? 8.25152   14.40612  56.22806 1.000 35.49678  ? 114 ARG A NE  1 
ATOM   874  C  CZ  . ARG A 1 114 ? 8.72567   14.58824  57.45157 1.000 45.42068  ? 114 ARG A CZ  1 
ATOM   875  N  NH1 . ARG A 1 114 ? 9.89433   15.18791  57.65794 1.000 37.63623  ? 114 ARG A NH1 1 
ATOM   876  N  NH2 . ARG A 1 114 ? 8.02174   14.14630  58.49021 1.000 27.85515  ? 114 ARG A NH2 1 
ATOM   877  N  N   . ALA A 1 115 ? 11.22687  14.36767  50.12881 1.000 28.00141  ? 115 ALA A N   1 
ATOM   878  C  CA  . ALA A 1 115 ? 11.78976  15.18107  49.04114 1.000 34.24944  ? 115 ALA A CA  1 
ATOM   879  C  C   . ALA A 1 115 ? 11.60758  14.51320  47.68332 1.000 25.72500  ? 115 ALA A C   1 
ATOM   880  O  O   . ALA A 1 115 ? 11.28228  15.18321  46.70742 1.000 35.98622  ? 115 ALA A O   1 
ATOM   881  C  CB  . ALA A 1 115 ? 13.28406  15.47751  49.28998 1.000 20.08276  ? 115 ALA A CB  1 
ATOM   882  N  N   . ASP A 1 116 ? 11.82733  13.19982  47.58673 1.000 31.72045  ? 116 ASP A N   1 
ATOM   883  C  CA  . ASP A 1 116 ? 11.66545  12.53691  46.28928 1.000 28.74736  ? 116 ASP A CA  1 
ATOM   884  C  C   . ASP A 1 116 ? 10.29129  12.80241  45.71332 1.000 31.80712  ? 116 ASP A C   1 
ATOM   885  O  O   . ASP A 1 116 ? 10.14396  12.95784  44.49676 1.000 35.74450  ? 116 ASP A O   1 
ATOM   886  C  CB  . ASP A 1 116 ? 11.88140  11.02326  46.39739 1.000 28.69981  ? 116 ASP A CB  1 
ATOM   887  C  CG  . ASP A 1 116 ? 13.32605  10.65028  46.71334 1.000 31.00184  ? 116 ASP A CG  1 
ATOM   888  O  OD1 . ASP A 1 116 ? 14.23684  11.45687  46.44388 1.000 34.01342  ? 116 ASP A OD1 1 
ATOM   889  O  OD2 . ASP A 1 116 ? 13.54640  9.53729   47.21945 1.000 24.40190  ? 116 ASP A OD2 1 
ATOM   890  N  N   . PHE A 1 117 ? 9.26765   12.84935  46.57812 1.000 35.13042  ? 117 PHE A N   1 
ATOM   891  C  CA  . PHE A 1 117 ? 7.89321   12.96353  46.10889 1.000 29.62367  ? 117 PHE A CA  1 
ATOM   892  C  C   . PHE A 1 117 ? 7.68155   14.25053  45.32529 1.000 36.81520  ? 117 PHE A C   1 
ATOM   893  O  O   . PHE A 1 117 ? 6.83917   14.29920  44.42422 1.000 32.41361  ? 117 PHE A O   1 
ATOM   894  C  CB  . PHE A 1 117 ? 6.92002   12.89780  47.28194 1.000 27.39060  ? 117 PHE A CB  1 
ATOM   895  C  CG  . PHE A 1 117 ? 5.47150   12.94123  46.86491 1.000 29.27652  ? 117 PHE A CG  1 
ATOM   896  C  CD1 . PHE A 1 117 ? 4.82168   11.78898  46.45718 1.000 25.16756  ? 117 PHE A CD1 1 
ATOM   897  C  CD2 . PHE A 1 117 ? 4.76562   14.13930  46.86630 1.000 28.69516  ? 117 PHE A CD2 1 
ATOM   898  C  CE1 . PHE A 1 117 ? 3.47829   11.82247  46.05776 1.000 31.92733  ? 117 PHE A CE1 1 
ATOM   899  C  CE2 . PHE A 1 117 ? 3.43343   14.17892  46.47026 1.000 25.34614  ? 117 PHE A CE2 1 
ATOM   900  C  CZ  . PHE A 1 117 ? 2.78882   13.02553  46.05849 1.000 24.21923  ? 117 PHE A CZ  1 
ATOM   901  N  N   A GLU A 1 118 ? 8.44817   15.28970  45.64081 0.573 35.91349  ? 118 GLU A N   1 
ATOM   902  N  N   B GLU A 1 118 ? 8.43055   15.30318  45.65703 0.427 39.29670  ? 118 GLU A N   1 
ATOM   903  C  CA  A GLU A 1 118 ? 8.28649   16.58754  45.00693 0.573 39.70950  ? 118 GLU A CA  1 
ATOM   904  C  CA  B GLU A 1 118 ? 8.26587   16.58678  44.98729 0.427 43.37914  ? 118 GLU A CA  1 
ATOM   905  C  C   A GLU A 1 118 ? 8.75413   16.60012  43.55777 0.573 43.97805  ? 118 GLU A C   1 
ATOM   906  C  C   B GLU A 1 118 ? 8.48276   16.48263  43.48329 0.427 43.64325  ? 118 GLU A C   1 
ATOM   907  O  O   A GLU A 1 118 ? 8.70528   17.65996  42.92083 0.573 44.88681  ? 118 GLU A O   1 
ATOM   908  O  O   B GLU A 1 118 ? 7.97947   17.32632  42.73197 0.427 45.80277  ? 118 GLU A O   1 
ATOM   909  C  CB  A GLU A 1 118 ? 9.03112   17.64920  45.82298 0.573 40.75231  ? 118 GLU A CB  1 
ATOM   910  C  CB  B GLU A 1 118 ? 9.23773   17.61515  45.58076 0.427 40.82975  ? 118 GLU A CB  1 
ATOM   911  C  CG  A GLU A 1 118 ? 8.44864   17.87903  47.21529 0.573 40.19627  ? 118 GLU A CG  1 
ATOM   912  C  CG  B GLU A 1 118 ? 9.20971   17.73660  47.09648 0.427 37.53785  ? 118 GLU A CG  1 
ATOM   913  C  CD  A GLU A 1 118 ? 6.95938   18.22915  47.18595 0.573 42.01351  ? 118 GLU A CD  1 
ATOM   914  C  CD  B GLU A 1 118 ? 10.14554  18.81751  47.60587 0.427 44.87762  ? 118 GLU A CD  1 
ATOM   915  O  OE1 A GLU A 1 118 ? 6.49089   18.82537  46.18788 0.573 32.33411  ? 118 GLU A OE1 1 
ATOM   916  O  OE1 B GLU A 1 118 ? 10.87883  19.41135  46.77969 0.427 47.96021  ? 118 GLU A OE1 1 
ATOM   917  O  OE2 A GLU A 1 118 ? 6.26106   17.89240  48.16798 0.573 33.12000  ? 118 GLU A OE2 1 
ATOM   918  O  OE2 B GLU A 1 118 ? 10.15433  19.07602  48.83205 0.427 47.59323  ? 118 GLU A OE2 1 
ATOM   919  N  N   . ASN A 1 119 ? 9.19931   15.45814  43.03179 1.000 39.73861  ? 119 ASN A N   1 
ATOM   920  C  CA  . ASN A 1 119 ? 9.61068   15.33399  41.64706 1.000 31.14612  ? 119 ASN A CA  1 
ATOM   921  C  C   . ASN A 1 119 ? 8.54851   14.70198  40.77317 1.000 34.94579  ? 119 ASN A C   1 
ATOM   922  O  O   . ASN A 1 119 ? 8.76542   14.56711  39.56767 1.000 42.38049  ? 119 ASN A O   1 
ATOM   923  C  CB  . ASN A 1 119 ? 10.89858  14.52347  41.57017 1.000 34.01295  ? 119 ASN A CB  1 
ATOM   924  C  CG  . ASN A 1 119 ? 12.02186  15.16303  42.34885 1.000 40.92052  ? 119 ASN A CG  1 
ATOM   925  O  OD1 . ASN A 1 119 ? 12.77667  15.96767  41.80440 1.000 36.34810  ? 119 ASN A OD1 1 
ATOM   926  N  ND2 . ASN A 1 119 ? 12.13217  14.82584  43.63164 1.000 40.50572  ? 119 ASN A ND2 1 
ATOM   927  N  N   . PHE A 1 120 ? 7.40306   14.34504  41.33606 1.000 35.75720  ? 120 PHE A N   1 
ATOM   928  C  CA  . PHE A 1 120 ? 6.37639   13.61549  40.61173 1.000 36.76179  ? 120 PHE A CA  1 
ATOM   929  C  C   . PHE A 1 120 ? 5.29714   14.56306  40.10322 1.000 37.99340  ? 120 PHE A C   1 
ATOM   930  O  O   . PHE A 1 120 ? 4.75966   15.34727  40.88646 1.000 36.42575  ? 120 PHE A O   1 
ATOM   931  C  CB  . PHE A 1 120 ? 5.74399   12.56367  41.51606 1.000 33.54514  ? 120 PHE A CB  1 
ATOM   932  C  CG  . PHE A 1 120 ? 6.71782   11.53020  42.05371 1.000 39.69948  ? 120 PHE A CG  1 
ATOM   933  C  CD1 . PHE A 1 120 ? 7.85484   11.16886  41.34031 1.000 34.05556  ? 120 PHE A CD1 1 
ATOM   934  C  CD2 . PHE A 1 120 ? 6.48043   10.91221  43.28457 1.000 36.65445  ? 120 PHE A CD2 1 
ATOM   935  C  CE1 . PHE A 1 120 ? 8.73352   10.21415  41.83756 1.000 29.41036  ? 120 PHE A CE1 1 
ATOM   936  C  CE2 . PHE A 1 120 ? 7.35470   9.96497   43.79086 1.000 32.76236  ? 120 PHE A CE2 1 
ATOM   937  C  CZ  . PHE A 1 120 ? 8.48934   9.61110   43.07206 1.000 30.13568  ? 120 PHE A CZ  1 
ATOM   938  N  N   . PRO A 1 121 ? 4.95337   14.53034  38.81201 1.000 46.14423  ? 121 PRO A N   1 
ATOM   939  C  CA  . PRO A 1 121 ? 3.76517   15.25793  38.34091 1.000 38.72276  ? 121 PRO A CA  1 
ATOM   940  C  C   . PRO A 1 121 ? 2.48097   14.63919  38.86660 1.000 40.34749  ? 121 PRO A C   1 
ATOM   941  O  O   . PRO A 1 121 ? 1.88900   13.76752  38.21355 1.000 35.97101  ? 121 PRO A O   1 
ATOM   942  C  CB  . PRO A 1 121 ? 3.85905   15.12917  36.81523 1.000 43.50613  ? 121 PRO A CB  1 
ATOM   943  C  CG  . PRO A 1 121 ? 4.59206   13.83794  36.59559 1.000 47.74931  ? 121 PRO A CG  1 
ATOM   944  C  CD  . PRO A 1 121 ? 5.62179   13.80243  37.71741 1.000 45.89856  ? 121 PRO A CD  1 
ATOM   945  N  N   . VAL A 1 122 ? 2.06415   15.06359  40.05637 1.000 32.46075  ? 122 VAL A N   1 
ATOM   946  C  CA  . VAL A 1 122 ? 0.83459   14.58403  40.67706 1.000 42.06429  ? 122 VAL A CA  1 
ATOM   947  C  C   . VAL A 1 122 ? -0.34763  15.09119  39.86386 1.000 38.75317  ? 122 VAL A C   1 
ATOM   948  O  O   . VAL A 1 122 ? -0.53134  16.30583  39.73776 1.000 43.71987  ? 122 VAL A O   1 
ATOM   949  C  CB  . VAL A 1 122 ? 0.74027   15.03406  42.14103 1.000 40.27829  ? 122 VAL A CB  1 
ATOM   950  C  CG1 . VAL A 1 122 ? -0.53528  14.49718  42.77281 1.000 34.98107  ? 122 VAL A CG1 1 
ATOM   951  C  CG2 . VAL A 1 122 ? 1.96386   14.54498  42.89964 1.000 36.98257  ? 122 VAL A CG2 1 
ATOM   952  N  N   . PRO A 1 123 ? -1.15632  14.20952  39.28211 1.000 42.56157  ? 123 PRO A N   1 
ATOM   953  C  CA  . PRO A 1 123 ? -2.18185  14.68895  38.34319 1.000 50.50930  ? 123 PRO A CA  1 
ATOM   954  C  C   . PRO A 1 123 ? -3.22207  15.60599  38.97496 1.000 56.29158  ? 123 PRO A C   1 
ATOM   955  O  O   . PRO A 1 123 ? -3.66356  16.55472  38.31503 1.000 48.73297  ? 123 PRO A O   1 
ATOM   956  C  CB  . PRO A 1 123 ? -2.80511  13.39295  37.81434 1.000 44.48123  ? 123 PRO A CB  1 
ATOM   957  C  CG  . PRO A 1 123 ? -2.41288  12.32482  38.79471 1.000 48.09877  ? 123 PRO A CG  1 
ATOM   958  C  CD  . PRO A 1 123 ? -1.11050  12.74138  39.37597 1.000 41.48082  ? 123 PRO A CD  1 
ATOM   959  N  N   . GLU A 1 124 ? -3.61698  15.37892  40.22941 1.000 48.68317  ? 124 GLU A N   1 
ATOM   960  C  CA  . GLU A 1 124 ? -4.63643  16.20345  40.87478 1.000 51.01272  ? 124 GLU A CA  1 
ATOM   961  C  C   . GLU A 1 124 ? -4.09116  16.83445  42.14356 1.000 50.04711  ? 124 GLU A C   1 
ATOM   962  O  O   . GLU A 1 124 ? -3.43171  16.16836  42.94163 1.000 54.30337  ? 124 GLU A O   1 
ATOM   963  C  CB  . GLU A 1 124 ? -5.87561  15.39083  41.22394 1.000 41.65023  ? 124 GLU A CB  1 
ATOM   964  C  CG  . GLU A 1 124 ? -6.39629  14.57768  40.06504 1.000 54.18562  ? 124 GLU A CG  1 
ATOM   965  C  CD  . GLU A 1 124 ? -7.07385  15.43724  39.01523 1.000 54.39438  ? 124 GLU A CD  1 
ATOM   966  O  OE1 . GLU A 1 124 ? -7.34085  16.62627  39.30434 1.000 48.87994  ? 124 GLU A OE1 1 
ATOM   967  O  OE2 . GLU A 1 124 ? -7.32792  14.91440  37.90681 1.000 57.38674  ? 124 GLU A OE2 1 
ATOM   968  N  N   . GLU A 1 125 ? -4.40562  18.11197  42.34798 1.000 56.11132  ? 125 GLU A N   1 
ATOM   969  C  CA  . GLU A 1 125 ? -3.96036  18.77610  43.56347 1.000 52.26698  ? 125 GLU A CA  1 
ATOM   970  C  C   . GLU A 1 125 ? -4.61460  18.17883  44.80990 1.000 49.83509  ? 125 GLU A C   1 
ATOM   971  O  O   . GLU A 1 125 ? -3.99347  18.16406  45.87697 1.000 54.42040  ? 125 GLU A O   1 
ATOM   972  C  CB  . GLU A 1 125 ? -4.21557  20.28359  43.46397 1.000 57.47550  ? 125 GLU A CB  1 
ATOM   973  C  CG  . GLU A 1 125 ? -3.76762  21.08183  44.68786 1.000 63.95213  ? 125 GLU A CG  1 
ATOM   974  C  CD  . GLU A 1 125 ? -4.93748  21.51345  45.54267 1.000 74.49709  ? 125 GLU A CD  1 
ATOM   975  O  OE1 . GLU A 1 125 ? -5.78928  22.27644  45.02885 1.000 81.83175  ? 125 GLU A OE1 1 
ATOM   976  O  OE2 . GLU A 1 125 ? -5.02079  21.07190  46.71413 1.000 71.84909  ? 125 GLU A OE2 1 
ATOM   977  N  N   . SER A 1 126 ? -5.83975  17.65614  44.71144 1.000 44.33792  ? 126 SER A N   1 
ATOM   978  C  CA  . SER A 1 126 ? -6.44368  17.07869  45.90947 1.000 47.28688  ? 126 SER A CA  1 
ATOM   979  C  C   . SER A 1 126 ? -5.66568  15.87127  46.41339 1.000 47.92462  ? 126 SER A C   1 
ATOM   980  O  O   . SER A 1 126 ? -5.76981  15.52861  47.59782 1.000 37.38183  ? 126 SER A O   1 
ATOM   981  C  CB  . SER A 1 126 ? -7.90889  16.69725  45.66313 1.000 35.92065  ? 126 SER A CB  1 
ATOM   982  O  OG  . SER A 1 126 ? -8.04560  15.47013  44.96915 1.000 42.50841  ? 126 SER A OG  1 
ATOM   983  N  N   . TRP A 1 127 ? -4.86138  15.24779  45.54831 1.000 47.27912  ? 127 TRP A N   1 
ATOM   984  C  CA  . TRP A 1 127 ? -4.16071  14.02687  45.93117 1.000 49.44712  ? 127 TRP A CA  1 
ATOM   985  C  C   . TRP A 1 127 ? -3.16025  14.27796  47.04469 1.000 35.78563  ? 127 TRP A C   1 
ATOM   986  O  O   . TRP A 1 127 ? -2.89996  13.37777  47.84646 1.000 35.91887  ? 127 TRP A O   1 
ATOM   987  C  CB  . TRP A 1 127 ? -3.48365  13.40572  44.70149 1.000 44.52722  ? 127 TRP A CB  1 
ATOM   988  C  CG  . TRP A 1 127 ? -4.47499  12.69588  43.82611 1.000 45.99674  ? 127 TRP A CG  1 
ATOM   989  C  CD1 . TRP A 1 127 ? -5.82543  12.86991  43.82994 1.000 43.23906  ? 127 TRP A CD1 1 
ATOM   990  C  CD2 . TRP A 1 127 ? -4.20569  11.67937  42.85215 1.000 53.75563  ? 127 TRP A CD2 1 
ATOM   991  N  NE1 . TRP A 1 127 ? -6.41456  12.04783  42.90518 1.000 45.53738  ? 127 TRP A NE1 1 
ATOM   992  C  CE2 . TRP A 1 127 ? -5.44310  11.30858  42.28698 1.000 50.62936  ? 127 TRP A CE2 1 
ATOM   993  C  CE3 . TRP A 1 127 ? -3.03697  11.07096  42.37959 1.000 48.64149  ? 127 TRP A CE3 1 
ATOM   994  C  CZ2 . TRP A 1 127 ? -5.54837  10.34367  41.28953 1.000 55.68738  ? 127 TRP A CZ2 1 
ATOM   995  C  CZ3 . TRP A 1 127 ? -3.14063  10.12101  41.38886 1.000 49.52128  ? 127 TRP A CZ3 1 
ATOM   996  C  CH2 . TRP A 1 127 ? -4.38825  9.75527   40.85858 1.000 49.71385  ? 127 TRP A CH2 1 
ATOM   997  N  N   . LEU A 1 128 ? -2.62562  15.49951  47.12854 1.000 36.37636  ? 128 LEU A N   1 
ATOM   998  C  CA  . LEU A 1 128 ? -1.69685  15.88589  48.18165 1.000 38.09898  ? 128 LEU A CA  1 
ATOM   999  C  C   . LEU A 1 128 ? -2.30515  15.83546  49.57708 1.000 45.06515  ? 128 LEU A C   1 
ATOM   1000 O  O   . LEU A 1 128 ? -1.54667  15.87166  50.55650 1.000 45.41507  ? 128 LEU A O   1 
ATOM   1001 C  CB  . LEU A 1 128 ? -1.16431  17.28577  47.92398 1.000 37.11592  ? 128 LEU A CB  1 
ATOM   1002 C  CG  . LEU A 1 128 ? -0.41477  17.47584  46.61246 1.000 42.81756  ? 128 LEU A CG  1 
ATOM   1003 C  CD1 . LEU A 1 128 ? 0.20877   18.85919  46.55989 1.000 46.23687  ? 128 LEU A CD1 1 
ATOM   1004 C  CD2 . LEU A 1 128 ? 0.62855   16.43212  46.53295 1.000 40.30633  ? 128 LEU A CD2 1 
ATOM   1005 N  N   . ASP A 1 129 ? -3.63242  15.73757  49.69643 1.000 43.21261  ? 129 ASP A N   1 
ATOM   1006 C  CA  . ASP A 1 129 ? -4.31220  15.64497  50.98650 1.000 37.03016  ? 129 ASP A CA  1 
ATOM   1007 C  C   . ASP A 1 129 ? -4.77765  14.23266  51.30404 1.000 34.08242  ? 129 ASP A C   1 
ATOM   1008 O  O   . ASP A 1 129 ? -5.32011  14.00486  52.38674 1.000 39.14322  ? 129 ASP A O   1 
ATOM   1009 C  CB  . ASP A 1 129 ? -5.51998  16.60226  51.03517 1.000 28.84096  ? 129 ASP A CB  1 
ATOM   1010 C  CG  . ASP A 1 129 ? -5.11802  18.06598  50.92565 1.000 45.48081  ? 129 ASP A CG  1 
ATOM   1011 O  OD1 . ASP A 1 129 ? -4.30089  18.52752  51.75899 1.000 50.45090  ? 129 ASP A OD1 1 
ATOM   1012 O  OD2 . ASP A 1 129 ? -5.61149  18.75351  49.99555 1.000 52.94845  ? 129 ASP A OD2 1 
ATOM   1013 N  N   . ASP A 1 130 ? -4.60329  13.29405  50.38849 1.000 36.03077  ? 130 ASP A N   1 
ATOM   1014 C  CA  . ASP A 1 130 ? -4.90911  11.89119  50.59750 1.000 31.89216  ? 130 ASP A CA  1 
ATOM   1015 C  C   . ASP A 1 130 ? -3.69360  11.15102  51.13982 1.000 39.03045  ? 130 ASP A C   1 
ATOM   1016 O  O   . ASP A 1 130 ? -2.55102  11.61226  51.00583 1.000 32.73549  ? 130 ASP A O   1 
ATOM   1017 C  CB  . ASP A 1 130 ? -5.34848  11.25140  49.29104 1.000 37.56065  ? 130 ASP A CB  1 
ATOM   1018 C  CG  . ASP A 1 130 ? -6.64495  11.81691  48.76628 1.000 42.17926  ? 130 ASP A CG  1 
ATOM   1019 O  OD1 . ASP A 1 130 ? -7.58895  11.96734  49.56454 1.000 57.96899  ? 130 ASP A OD1 1 
ATOM   1020 O  OD2 . ASP A 1 130 ? -6.70789  12.10634  47.55079 1.000 47.94214  ? 130 ASP A OD2 1 
ATOM   1021 N  N   . PRO A 1 131 ? -3.91714  10.01030  51.79606 1.000 42.75200  ? 131 PRO A N   1 
ATOM   1022 C  CA  . PRO A 1 131 ? -2.79860  9.12515   52.12949 1.000 33.28182  ? 131 PRO A CA  1 
ATOM   1023 C  C   . PRO A 1 131 ? -2.20797  8.49433   50.88229 1.000 40.66370  ? 131 PRO A C   1 
ATOM   1024 O  O   . PRO A 1 131 ? -2.90034  8.24934   49.88740 1.000 41.57059  ? 131 PRO A O   1 
ATOM   1025 C  CB  . PRO A 1 131 ? -3.43776  8.04677   53.01298 1.000 34.42635  ? 131 PRO A CB  1 
ATOM   1026 C  CG  . PRO A 1 131 ? -4.80818  8.51306   53.30504 1.000 39.72283  ? 131 PRO A CG  1 
ATOM   1027 C  CD  . PRO A 1 131 ? -5.21195  9.45857   52.24166 1.000 29.78354  ? 131 PRO A CD  1 
ATOM   1028 N  N   . TRP A 1 132 ? -0.91211  8.21154   50.95252 1.000 40.14934  ? 132 TRP A N   1 
ATOM   1029 C  CA  . TRP A 1 132 ? -0.23333  7.41641   49.94067 1.000 35.12112  ? 132 TRP A CA  1 
ATOM   1030 C  C   . TRP A 1 132 ? 0.48916   6.25528   50.62116 1.000 32.92953  ? 132 TRP A C   1 
ATOM   1031 O  O   . TRP A 1 132 ? 1.11554   6.42019   51.67596 1.000 35.12135  ? 132 TRP A O   1 
ATOM   1032 C  CB  . TRP A 1 132 ? 0.77641   8.24806   49.15110 1.000 28.11484  ? 132 TRP A CB  1 
ATOM   1033 C  CG  . TRP A 1 132 ? 0.23702   9.34433   48.24563 1.000 34.58334  ? 132 TRP A CG  1 
ATOM   1034 C  CD1 . TRP A 1 132 ? -0.49445  10.43788  48.61501 1.000 36.28553  ? 132 TRP A CD1 1 
ATOM   1035 C  CD2 . TRP A 1 132 ? 0.48014   9.48664   46.83278 1.000 30.52496  ? 132 TRP A CD2 1 
ATOM   1036 N  NE1 . TRP A 1 132 ? -0.75065  11.23625  47.51598 1.000 36.31779  ? 132 TRP A NE1 1 
ATOM   1037 C  CE2 . TRP A 1 132 ? -0.16599  10.67075  46.41164 1.000 35.77914  ? 132 TRP A CE2 1 
ATOM   1038 C  CE3 . TRP A 1 132 ? 1.15398   8.71382   45.88401 1.000 33.93909  ? 132 TRP A CE3 1 
ATOM   1039 C  CZ2 . TRP A 1 132 ? -0.15889  11.09605  45.08100 1.000 37.53012  ? 132 TRP A CZ2 1 
ATOM   1040 C  CZ3 . TRP A 1 132 ? 1.16744   9.14436   44.53847 1.000 35.91397  ? 132 TRP A CZ3 1 
ATOM   1041 C  CH2 . TRP A 1 132 ? 0.51310   10.32113  44.15829 1.000 33.17725  ? 132 TRP A CH2 1 
ATOM   1042 N  N   . ASP A 1 133 ? 0.39277   5.07879   50.03285 1.000 27.81248  ? 133 ASP A N   1 
ATOM   1043 C  CA  . ASP A 1 133 ? 1.24203   3.98562   50.45756 1.000 31.80175  ? 133 ASP A CA  1 
ATOM   1044 C  C   . ASP A 1 133 ? 2.59233   4.14542   49.78626 1.000 30.32923  ? 133 ASP A C   1 
ATOM   1045 O  O   . ASP A 1 133 ? 2.66175   4.34956   48.57014 1.000 34.09187  ? 133 ASP A O   1 
ATOM   1046 C  CB  . ASP A 1 133 ? 0.62515   2.63868   50.09537 1.000 36.59386  ? 133 ASP A CB  1 
ATOM   1047 C  CG  . ASP A 1 133 ? 1.53907   1.47486   50.43448 1.000 41.39513  ? 133 ASP A CG  1 
ATOM   1048 O  OD1 . ASP A 1 133 ? 1.51571   1.03073   51.60285 1.000 48.31941  ? 133 ASP A OD1 1 
ATOM   1049 O  OD2 . ASP A 1 133 ? 2.28353   1.01340   49.53876 1.000 40.17442  ? 133 ASP A OD2 1 
ATOM   1050 N  N   . VAL A 1 134 ? 3.66121   4.07994   50.57226 1.000 25.48028  ? 134 VAL A N   1 
ATOM   1051 C  CA  . VAL A 1 134 ? 5.01318   4.20514   50.04615 1.000 27.64729  ? 134 VAL A CA  1 
ATOM   1052 C  C   . VAL A 1 134 ? 5.77729   2.94082   50.41663 1.000 26.69705  ? 134 VAL A C   1 
ATOM   1053 O  O   . VAL A 1 134 ? 6.09965   2.72844   51.59126 1.000 32.83005  ? 134 VAL A O   1 
ATOM   1054 C  CB  . VAL A 1 134 ? 5.72066   5.46223   50.56497 1.000 23.51695  ? 134 VAL A CB  1 
ATOM   1055 C  CG1 . VAL A 1 134 ? 7.08816   5.56716   49.95494 1.000 22.98966  ? 134 VAL A CG1 1 
ATOM   1056 C  CG2 . VAL A 1 134 ? 4.91187   6.69501   50.22363 1.000 21.62292  ? 134 VAL A CG2 1 
ATOM   1057 N  N   . GLN A 1 135 ? 6.05229   2.09215   49.42719 1.000 29.81641  ? 135 GLN A N   1 
ATOM   1058 C  CA  . GLN A 1 135 ? 6.89766   0.92034   49.64131 1.000 25.27040  ? 135 GLN A CA  1 
ATOM   1059 C  C   . GLN A 1 135 ? 8.35706   1.31524   49.60219 1.000 25.79595  ? 135 GLN A C   1 
ATOM   1060 O  O   . GLN A 1 135 ? 8.79630   2.08439   48.73517 1.000 22.88357  ? 135 GLN A O   1 
ATOM   1061 C  CB  . GLN A 1 135 ? 6.63933   -0.14268  48.58389 1.000 26.93861  ? 135 GLN A CB  1 
ATOM   1062 C  CG  . GLN A 1 135 ? 5.23390   -0.66398  48.59898 1.000 34.50025  ? 135 GLN A CG  1 
ATOM   1063 C  CD  . GLN A 1 135 ? 4.98080   -1.59665  47.44696 1.000 33.90560  ? 135 GLN A CD  1 
ATOM   1064 O  OE1 . GLN A 1 135 ? 5.51081   -2.70064  47.40984 1.000 47.32103  ? 135 GLN A OE1 1 
ATOM   1065 N  NE2 . GLN A 1 135 ? 4.15661   -1.16616  46.50628 1.000 23.79337  ? 135 GLN A NE2 1 
ATOM   1066 N  N   . CYS A 1 136 ? 9.11092   0.78437   50.54853 1.000 23.31375  ? 136 CYS A N   1 
ATOM   1067 C  CA  . CYS A 1 136 ? 10.52494  1.09201   50.67458 1.000 25.38368  ? 136 CYS A CA  1 
ATOM   1068 C  C   . CYS A 1 136 ? 11.30509  -0.21323  50.60482 1.000 26.58799  ? 136 CYS A C   1 
ATOM   1069 O  O   . CYS A 1 136 ? 11.17104  -1.04851  51.50632 1.000 31.78992  ? 136 CYS A O   1 
ATOM   1070 C  CB  . CYS A 1 136 ? 10.80163  1.83051   51.99308 1.000 19.59494  ? 136 CYS A CB  1 
ATOM   1071 S  SG  . CYS A 1 136 ? 12.53590  2.28904   52.17870 1.000 26.47304  ? 136 CYS A SG  1 
ATOM   1072 N  N   . HIS A 1 137 ? 12.11413  -0.38651  49.55112 1.000 28.08855  ? 137 HIS A N   1 
ATOM   1073 C  CA  . HIS A 1 137 ? 12.91487  -1.59714  49.36186 1.000 31.89139  ? 137 HIS A CA  1 
ATOM   1074 C  C   . HIS A 1 137 ? 14.39871  -1.28709  49.49777 1.000 25.59987  ? 137 HIS A C   1 
ATOM   1075 O  O   . HIS A 1 137 ? 14.90855  -0.39953  48.80544 1.000 29.10122  ? 137 HIS A O   1 
ATOM   1076 C  CB  . HIS A 1 137 ? 12.69742  -2.22030  47.98076 1.000 30.81047  ? 137 HIS A CB  1 
ATOM   1077 C  CG  . HIS A 1 137 ? 11.27743  -2.23247  47.51730 1.000 41.01762  ? 137 HIS A CG  1 
ATOM   1078 N  ND1 . HIS A 1 137 ? 10.50042  -3.37038  47.54163 1.000 45.53842  ? 137 HIS A ND1 1 
ATOM   1079 C  CD2 . HIS A 1 137 ? 10.50313  -1.26235  46.97894 1.000 37.96000  ? 137 HIS A CD2 1 
ATOM   1080 C  CE1 . HIS A 1 137 ? 9.30871   -3.10441  47.03955 1.000 40.06250  ? 137 HIS A CE1 1 
ATOM   1081 N  NE2 . HIS A 1 137 ? 9.28307   -1.82869  46.70146 1.000 35.88000  ? 137 HIS A NE2 1 
ATOM   1082 N  N   . GLN A 1 138 ? 15.09440  -2.02687  50.36426 1.000 25.26707  ? 138 GLN A N   1 
ATOM   1083 C  CA  . GLN A 1 138 ? 16.54975  -2.10093  50.32119 1.000 22.25519  ? 138 GLN A CA  1 
ATOM   1084 C  C   . GLN A 1 138 ? 16.95592  -3.38106  49.57733 1.000 32.49349  ? 138 GLN A C   1 
ATOM   1085 O  O   . GLN A 1 138 ? 16.71049  -4.48496  50.06125 1.000 35.49471  ? 138 GLN A O   1 
ATOM   1086 C  CB  . GLN A 1 138 ? 17.15058  -2.06724  51.72342 1.000 25.47266  ? 138 GLN A CB  1 
ATOM   1087 C  CG  . GLN A 1 138 ? 16.79524  -0.83493  52.57049 1.000 31.18652  ? 138 GLN A CG  1 
ATOM   1088 C  CD  . GLN A 1 138 ? 17.42722  -0.86779  53.97354 1.000 29.09262  ? 138 GLN A CD  1 
ATOM   1089 O  OE1 . GLN A 1 138 ? 17.25279  -1.82356  54.72606 1.000 35.53530  ? 138 GLN A OE1 1 
ATOM   1090 N  NE2 . GLN A 1 138 ? 18.16561  0.17288   54.31491 1.000 23.16687  ? 138 GLN A NE2 1 
ATOM   1091 N  N   . PHE A 1 139 ? 17.57533  -3.23591  48.40594 1.000 28.19787  ? 139 PHE A N   1 
ATOM   1092 C  CA  . PHE A 1 139 ? 17.99936  -4.36995  47.58269 1.000 30.48922  ? 139 PHE A CA  1 
ATOM   1093 C  C   . PHE A 1 139 ? 19.51487  -4.39697  47.50215 1.000 32.26790  ? 139 PHE A C   1 
ATOM   1094 O  O   . PHE A 1 139 ? 20.13283  -3.38914  47.14001 1.000 34.19564  ? 139 PHE A O   1 
ATOM   1095 C  CB  . PHE A 1 139 ? 17.46545  -4.29565  46.14010 1.000 28.61312  ? 139 PHE A CB  1 
ATOM   1096 C  CG  . PHE A 1 139 ? 16.07875  -4.75951  45.97739 1.000 36.01347  ? 139 PHE A CG  1 
ATOM   1097 C  CD1 . PHE A 1 139 ? 15.68765  -5.99576  46.45898 1.000 53.04029  ? 139 PHE A CD1 1 
ATOM   1098 C  CD2 . PHE A 1 139 ? 15.13826  -3.95313  45.34433 1.000 49.61751  ? 139 PHE A CD2 1 
ATOM   1099 C  CE1 . PHE A 1 139 ? 14.38596  -6.43331  46.31438 1.000 57.12651  ? 139 PHE A CE1 1 
ATOM   1100 C  CE2 . PHE A 1 139 ? 13.81974  -4.38199  45.20103 1.000 52.44381  ? 139 PHE A CE2 1 
ATOM   1101 C  CZ  . PHE A 1 139 ? 13.44909  -5.62313  45.68159 1.000 56.47751  ? 139 PHE A CZ  1 
ATOM   1102 N  N   . ARG A 1 140 ? 20.10841  -5.55212  47.80355 1.000 37.67380  ? 140 ARG A N   1 
ATOM   1103 C  CA  . ARG A 1 140 ? 21.51544  -5.82170  47.51345 1.000 40.89999  ? 140 ARG A CA  1 
ATOM   1104 C  C   . ARG A 1 140 ? 21.60266  -6.96329  46.49538 1.000 35.20021  ? 140 ARG A C   1 
ATOM   1105 O  O   . ARG A 1 140 ? 21.17550  -8.08855  46.77667 1.000 30.84756  ? 140 ARG A O   1 
ATOM   1106 C  CB  . ARG A 1 140 ? 22.29831  -6.14744  48.79478 1.000 34.46291  ? 140 ARG A CB  1 
ATOM   1107 C  CG  . ARG A 1 140 ? 23.54287  -7.03476  48.54263 1.000 38.12914  ? 140 ARG A CG  1 
ATOM   1108 C  CD  . ARG A 1 140 ? 24.61871  -6.89488  49.60150 1.000 36.25660  ? 140 ARG A CD  1 
ATOM   1109 N  NE  . ARG A 1 140 ? 25.26520  -5.58641  49.57445 1.000 41.67566  ? 140 ARG A NE  1 
ATOM   1110 C  CZ  . ARG A 1 140 ? 26.25604  -5.22859  50.38259 1.000 36.58408  ? 140 ARG A CZ  1 
ATOM   1111 N  NH1 . ARG A 1 140 ? 26.80610  -6.08815  51.21606 1.000 35.93977  ? 140 ARG A NH1 1 
ATOM   1112 N  NH2 . ARG A 1 140 ? 26.68875  -3.97062  50.37084 1.000 29.20432  ? 140 ARG A NH2 1 
ATOM   1113 N  N   . ILE A 1 141 ? 22.14245  -6.67168  45.31499 1.000 32.84911  ? 141 ILE A N   1 
ATOM   1114 C  CA  . ILE A 1 141 ? 22.32874  -7.67480  44.26880 1.000 34.40305  ? 141 ILE A CA  1 
ATOM   1115 C  C   . ILE A 1 141 ? 23.76550  -8.15661  44.31205 1.000 33.21447  ? 141 ILE A C   1 
ATOM   1116 O  O   . ILE A 1 141 ? 24.69847  -7.35017  44.22158 1.000 38.75936  ? 141 ILE A O   1 
ATOM   1117 C  CB  . ILE A 1 141 ? 21.99346  -7.11487  42.88002 1.000 38.49486  ? 141 ILE A CB  1 
ATOM   1118 C  CG1 . ILE A 1 141 ? 20.62454  -6.45467  42.90071 1.000 50.89035  ? 141 ILE A CG1 1 
ATOM   1119 C  CG2 . ILE A 1 141 ? 22.00216  -8.22905  41.85080 1.000 46.71616  ? 141 ILE A CG2 1 
ATOM   1120 C  CD1 . ILE A 1 141 ? 19.50890  -7.42929  43.16170 1.000 59.26714  ? 141 ILE A CD1 1 
ATOM   1121 N  N   . ILE A 1 142 ? 23.94698  -9.46787  44.44689 1.000 41.86481  ? 142 ILE A N   1 
ATOM   1122 C  CA  . ILE A 1 142 ? 25.26505  -10.09175 44.52106 1.000 39.38904  ? 142 ILE A CA  1 
ATOM   1123 C  C   . ILE A 1 142 ? 25.43004  -11.00792 43.32290 1.000 46.47412  ? 142 ILE A C   1 
ATOM   1124 O  O   . ILE A 1 142 ? 24.55585  -11.83977 43.04707 1.000 44.06599  ? 142 ILE A O   1 
ATOM   1125 C  CB  . ILE A 1 142 ? 25.46512  -10.89476 45.81685 1.000 46.80006  ? 142 ILE A CB  1 
ATOM   1126 C  CG1 . ILE A 1 142 ? 25.19624  -10.02973 47.03865 1.000 42.35483  ? 142 ILE A CG1 1 
ATOM   1127 C  CG2 . ILE A 1 142 ? 26.87820  -11.49110 45.85896 1.000 43.19777  ? 142 ILE A CG2 1 
ATOM   1128 C  CD1 . ILE A 1 142 ? 25.15498  -10.81845 48.30262 1.000 43.90001  ? 142 ILE A CD1 1 
ATOM   1129 N  N   . SER A 1 143 ? 26.54299  -10.83889 42.60632 1.000 47.79084  ? 143 SER A N   1 
ATOM   1130 C  CA  . SER A 1 143 ? 26.97996  -11.76794 41.57089 1.000 51.94105  ? 143 SER A CA  1 
ATOM   1131 C  C   . SER A 1 143 ? 28.32727  -12.32515 42.01502 1.000 52.04848  ? 143 SER A C   1 
ATOM   1132 O  O   . SER A 1 143 ? 29.34192  -11.62181 41.97948 1.000 48.56546  ? 143 SER A O   1 
ATOM   1133 C  CB  . SER A 1 143 ? 27.07405  -11.08378 40.22338 1.000 41.61465  ? 143 SER A CB  1 
ATOM   1134 O  OG  . SER A 1 143 ? 27.54956  -11.99308 39.25368 1.000 59.09020  ? 143 SER A OG  1 
ATOM   1135 N  N   . THR A 1 144 ? 28.32630  -13.59892 42.46542 1.000 63.43416  ? 144 THR A N   1 
ATOM   1136 C  CA  . THR A 1 144 ? 29.43902  -14.38648 42.98299 1.000 63.92200  ? 144 THR A CA  1 
ATOM   1137 C  C   . THR A 1 144 ? 30.20413  -15.04703 41.83651 1.000 67.12662  ? 144 THR A C   1 
ATOM   1138 O  O   . THR A 1 144 ? 29.62404  -15.35220 40.78764 1.000 70.48473  ? 144 THR A O   1 
ATOM   1139 C  CB  . THR A 1 144 ? 28.92447  -15.44952 43.95757 1.000 69.33157  ? 144 THR A CB  1 
ATOM   1140 O  OG1 . THR A 1 144 ? 30.02915  -16.11793 44.57521 1.000 86.27477  ? 144 THR A OG1 1 
ATOM   1141 C  CG2 . THR A 1 144 ? 28.04429  -16.47272 43.24009 1.000 73.10644  ? 144 THR A CG2 1 
ATOM   1142 N  N   . PRO A 1 145 ? 31.52533  -15.23745 41.98108 1.000 70.34100  ? 145 PRO A N   1 
ATOM   1143 C  CA  . PRO A 1 145 ? 32.32050  -15.82604 40.89496 1.000 77.17485  ? 145 PRO A CA  1 
ATOM   1144 C  C   . PRO A 1 145 ? 31.85447  -17.23158 40.46704 1.000 78.76213  ? 145 PRO A C   1 
ATOM   1145 O  O   . PRO A 1 145 ? 31.86271  -18.18078 41.26133 1.000 77.68021  ? 145 PRO A O   1 
ATOM   1146 C  CB  . PRO A 1 145 ? 33.73075  -15.87529 41.49093 1.000 68.05451  ? 145 PRO A CB  1 
ATOM   1147 C  CG  . PRO A 1 145 ? 33.75125  -14.77863 42.51830 1.000 59.60853  ? 145 PRO A CG  1 
ATOM   1148 C  CD  . PRO A 1 145 ? 32.37015  -14.77395 43.10029 1.000 72.41255  ? 145 PRO A CD  1 
ATOM   1149 N  N   . PRO A 1 153 ? 17.90516  -12.73799 34.63779 1.000 91.37248  ? 153 PRO A N   1 
ATOM   1150 C  CA  . PRO A 1 153 ? 17.42486  -11.36394 34.83116 1.000 86.17462  ? 153 PRO A CA  1 
ATOM   1151 C  C   . PRO A 1 153 ? 15.90770  -11.26917 34.76508 1.000 89.15223  ? 153 PRO A C   1 
ATOM   1152 O  O   . PRO A 1 153 ? 15.29040  -12.15778 34.17889 1.000 92.60767  ? 153 PRO A O   1 
ATOM   1153 C  CB  . PRO A 1 153 ? 18.05397  -10.60841 33.66068 1.000 76.29635  ? 153 PRO A CB  1 
ATOM   1154 C  CG  . PRO A 1 153 ? 18.19885  -11.64508 32.59060 1.000 83.44901  ? 153 PRO A CG  1 
ATOM   1155 C  CD  . PRO A 1 153 ? 18.54642  -12.91715 33.32104 1.000 83.65054  ? 153 PRO A CD  1 
ATOM   1156 N  N   . GLU A 1 154 ? 15.31855  -10.22639 35.35430 1.000 88.26183  ? 154 GLU A N   1 
ATOM   1157 C  CA  . GLU A 1 154 ? 13.89801  -9.96059  35.16212 1.000 80.61632  ? 154 GLU A CA  1 
ATOM   1158 C  C   . GLU A 1 154 ? 13.70835  -9.01683  33.97893 1.000 70.27636  ? 154 GLU A C   1 
ATOM   1159 O  O   . GLU A 1 154 ? 14.48170  -8.07653  33.79219 1.000 61.66819  ? 154 GLU A O   1 
ATOM   1160 C  CB  . GLU A 1 154 ? 13.24874  -9.36475  36.41590 1.000 73.43463  ? 154 GLU A CB  1 
ATOM   1161 C  CG  . GLU A 1 154 ? 11.75548  -9.08145  36.21855 1.000 73.13093  ? 154 GLU A CG  1 
ATOM   1162 C  CD  . GLU A 1 154 ? 11.04504  -8.61762  37.47657 1.000 74.22089  ? 154 GLU A CD  1 
ATOM   1163 O  OE1 . GLU A 1 154 ? 11.69295  -8.55460  38.55079 1.000 69.57246  ? 154 GLU A OE1 1 
ATOM   1164 O  OE2 . GLU A 1 154 ? 9.82932   -8.31894  37.37786 1.000 62.67320  ? 154 GLU A OE2 1 
ATOM   1165 N  N   . GLY A 1 155 ? 12.67177  -9.27722  33.18104 1.000 55.86610  ? 155 GLY A N   1 
ATOM   1166 C  CA  . GLY A 1 155 ? 12.38895  -8.49871  32.00260 1.000 36.64649  ? 155 GLY A CA  1 
ATOM   1167 C  C   . GLY A 1 155 ? 11.59152  -7.23885  32.27413 1.000 48.51371  ? 155 GLY A C   1 
ATOM   1168 O  O   . GLY A 1 155 ? 11.32080  -6.88626  33.42905 1.000 51.01454  ? 155 GLY A O   1 
ATOM   1169 N  N   . PRO A 1 156 ? 11.18936  -6.54509  31.20479 1.000 43.31944  ? 156 PRO A N   1 
ATOM   1170 C  CA  . PRO A 1 156 ? 10.53817  -5.23457  31.36359 1.000 39.55928  ? 156 PRO A CA  1 
ATOM   1171 C  C   . PRO A 1 156 ? 9.22572   -5.36061  32.11799 1.000 48.95809  ? 156 PRO A C   1 
ATOM   1172 O  O   . PRO A 1 156 ? 8.40418   -6.22737  31.81448 1.000 47.17497  ? 156 PRO A O   1 
ATOM   1173 C  CB  . PRO A 1 156 ? 10.29463  -4.76675  29.92267 1.000 41.13522  ? 156 PRO A CB  1 
ATOM   1174 C  CG  . PRO A 1 156 ? 10.94749  -5.77616  29.03108 1.000 35.27344  ? 156 PRO A CG  1 
ATOM   1175 C  CD  . PRO A 1 156 ? 11.17635  -7.02036  29.81077 1.000 36.82344  ? 156 PRO A CD  1 
ATOM   1176 N  N   . HIS A 1 157 ? 9.02593   -4.46573  33.08899 1.000 43.90249  ? 157 HIS A N   1 
ATOM   1177 C  CA  . HIS A 1 157 ? 7.89495   -4.54192  33.99931 1.000 38.09959  ? 157 HIS A CA  1 
ATOM   1178 C  C   . HIS A 1 157 ? 7.59370   -3.15439  34.54437 1.000 39.27045  ? 157 HIS A C   1 
ATOM   1179 O  O   . HIS A 1 157 ? 8.34880   -2.20460  34.33532 1.000 38.30499  ? 157 HIS A O   1 
ATOM   1180 C  CB  . HIS A 1 157 ? 8.17168   -5.51430  35.14516 1.000 39.89290  ? 157 HIS A CB  1 
ATOM   1181 C  CG  . HIS A 1 157 ? 9.23305   -5.04584  36.09242 1.000 46.37881  ? 157 HIS A CG  1 
ATOM   1182 N  ND1 . HIS A 1 157 ? 10.57910  -5.14129  35.81446 1.000 41.47980  ? 157 HIS A ND1 1 
ATOM   1183 C  CD2 . HIS A 1 157 ? 9.14355   -4.49083  37.32207 1.000 41.87757  ? 157 HIS A CD2 1 
ATOM   1184 C  CE1 . HIS A 1 157 ? 11.27205  -4.66310  36.83138 1.000 43.91076  ? 157 HIS A CE1 1 
ATOM   1185 N  NE2 . HIS A 1 157 ? 10.42430  -4.25846  37.75870 1.000 45.69122  ? 157 HIS A NE2 1 
ATOM   1186 N  N   . ARG A 1 158 ? 6.45317   -3.04167  35.21910 1.000 40.97023  ? 158 ARG A N   1 
ATOM   1187 C  CA  . ARG A 1 158 ? 6.13522   -1.89479  36.05618 1.000 37.51721  ? 158 ARG A CA  1 
ATOM   1188 C  C   . ARG A 1 158 ? 6.07143   -2.36382  37.49947 1.000 35.09869  ? 158 ARG A C   1 
ATOM   1189 O  O   . ARG A 1 158 ? 5.93631   -3.55964  37.77246 1.000 33.86674  ? 158 ARG A O   1 
ATOM   1190 C  CB  . ARG A 1 158 ? 4.80718   -1.26090  35.65754 1.000 37.34434  ? 158 ARG A CB  1 
ATOM   1191 C  CG  . ARG A 1 158 ? 3.62008   -2.15146  35.94731 1.000 41.35637  ? 158 ARG A CG  1 
ATOM   1192 C  CD  . ARG A 1 158 ? 2.35432   -1.40749  35.68678 1.000 34.60142  ? 158 ARG A CD  1 
ATOM   1193 N  NE  . ARG A 1 158 ? 2.31976   -0.16597  36.44809 1.000 42.83105  ? 158 ARG A NE  1 
ATOM   1194 C  CZ  . ARG A 1 158 ? 1.25255   0.61437   36.55024 1.000 41.12055  ? 158 ARG A CZ  1 
ATOM   1195 N  NH1 . ARG A 1 158 ? 0.10922   0.29666   35.96894 1.000 37.11027  ? 158 ARG A NH1 1 
ATOM   1196 N  NH2 . ARG A 1 158 ? 1.33396   1.73951   37.25415 1.000 38.35246  ? 158 ARG A NH2 1 
ATOM   1197 N  N   . ASP A 1 159 ? 6.18121   -1.42522  38.44003 1.000 40.20087  ? 159 ASP A N   1 
ATOM   1198 C  CA  . ASP A 1 159 ? 6.11730   -1.86110  39.83090 1.000 37.47875  ? 159 ASP A CA  1 
ATOM   1199 C  C   . ASP A 1 159 ? 4.70541   -1.83507  40.39856 1.000 32.43999  ? 159 ASP A C   1 
ATOM   1200 O  O   . ASP A 1 159 ? 4.52764   -2.24909  41.54857 1.000 31.37577  ? 159 ASP A O   1 
ATOM   1201 C  CB  . ASP A 1 159 ? 7.07711   -1.04037  40.70645 1.000 28.83256  ? 159 ASP A CB  1 
ATOM   1202 C  CG  . ASP A 1 159 ? 8.52635   -1.36061  40.41168 1.000 32.01616  ? 159 ASP A CG  1 
ATOM   1203 O  OD1 . ASP A 1 159 ? 8.77613   -2.27952  39.60087 1.000 43.92422  ? 159 ASP A OD1 1 
ATOM   1204 O  OD2 . ASP A 1 159 ? 9.43648   -0.71387  40.96297 1.000 31.21748  ? 159 ASP A OD2 1 
ATOM   1205 N  N   . GLU A 1 160 ? 3.70009   -1.40845  39.61339 1.000 29.86242  ? 160 GLU A N   1 
ATOM   1206 C  CA  . GLU A 1 160 ? 2.29620   -1.31945  40.06499 1.000 34.19491  ? 160 GLU A CA  1 
ATOM   1207 C  C   . GLU A 1 160 ? 2.14262   -0.29913  41.19556 1.000 36.12609  ? 160 GLU A C   1 
ATOM   1208 O  O   . GLU A 1 160 ? 1.56201   -0.58355  42.24722 1.000 42.29375  ? 160 GLU A O   1 
ATOM   1209 C  CB  . GLU A 1 160 ? 1.73417   -2.69216  40.48139 1.000 40.47910  ? 160 GLU A CB  1 
ATOM   1210 C  CG  . GLU A 1 160 ? 1.86153   -3.81420  39.40605 1.000 42.59463  ? 160 GLU A CG  1 
ATOM   1211 C  CD  . GLU A 1 160 ? 1.05231   -3.54478  38.10242 1.000 59.27072  ? 160 GLU A CD  1 
ATOM   1212 O  OE1 . GLU A 1 160 ? 0.47790   -2.44341  37.92607 1.000 49.91000  ? 160 GLU A OE1 1 
ATOM   1213 O  OE2 . GLU A 1 160 ? 0.98885   -4.45524  37.24416 1.000 64.99563  ? 160 GLU A OE2 1 
ATOM   1214 N  N   . VAL A 1 161 ? 2.70573   0.88850   40.97437 1.000 28.00079  ? 161 VAL A N   1 
ATOM   1215 C  CA  . VAL A 1 161 ? 2.57266   2.05373   41.83646 1.000 32.44988  ? 161 VAL A CA  1 
ATOM   1216 C  C   . VAL A 1 161 ? 2.28608   3.23719   40.91856 1.000 34.92356  ? 161 VAL A C   1 
ATOM   1217 O  O   . VAL A 1 161 ? 2.24683   3.09176   39.70135 1.000 31.81224  ? 161 VAL A O   1 
ATOM   1218 C  CB  . VAL A 1 161 ? 3.84354   2.31328   42.68251 1.000 31.12634  ? 161 VAL A CB  1 
ATOM   1219 C  CG1 . VAL A 1 161 ? 4.19928   1.11781   43.55939 1.000 22.93952  ? 161 VAL A CG1 1 
ATOM   1220 C  CG2 . VAL A 1 161 ? 5.00854   2.60968   41.76746 1.000 27.83146  ? 161 VAL A CG2 1 
ATOM   1221 N  N   . ASP A 1 162 ? 2.10482   4.42251   41.49489 1.000 31.60548  ? 162 ASP A N   1 
ATOM   1222 C  CA  . ASP A 1 162 ? 1.97797   5.59510   40.64141 1.000 23.64284  ? 162 ASP A CA  1 
ATOM   1223 C  C   . ASP A 1 162 ? 3.34023   6.14213   40.23472 1.000 37.60245  ? 162 ASP A C   1 
ATOM   1224 O  O   . ASP A 1 162 ? 3.55325   6.46519   39.06352 1.000 30.46290  ? 162 ASP A O   1 
ATOM   1225 C  CB  . ASP A 1 162 ? 1.14544   6.67675   41.33701 1.000 28.36274  ? 162 ASP A CB  1 
ATOM   1226 C  CG  . ASP A 1 162 ? -0.33473  6.26541   41.48776 1.000 48.57644  ? 162 ASP A CG  1 
ATOM   1227 O  OD1 . ASP A 1 162 ? -0.93484  5.86589   40.46418 1.000 52.93399  ? 162 ASP A OD1 1 
ATOM   1228 O  OD2 . ASP A 1 162 ? -0.88527  6.28371   42.61600 1.000 40.19828  ? 162 ASP A OD2 1 
ATOM   1229 N  N   . PHE A 1 163 ? 4.27092   6.25268   41.17880 1.000 32.83985  ? 163 PHE A N   1 
ATOM   1230 C  CA  . PHE A 1 163 ? 5.57763   6.82847   40.91579 1.000 31.21429  ? 163 PHE A CA  1 
ATOM   1231 C  C   . PHE A 1 163 ? 6.66004   6.04730   41.64943 1.000 30.29864  ? 163 PHE A C   1 
ATOM   1232 O  O   . PHE A 1 163 ? 6.41436   5.44344   42.69871 1.000 29.87585  ? 163 PHE A O   1 
ATOM   1233 C  CB  . PHE A 1 163 ? 5.62949   8.30740   41.32126 1.000 34.96727  ? 163 PHE A CB  1 
ATOM   1234 C  CG  . PHE A 1 163 ? 4.70022   9.16866   40.53652 1.000 42.47800  ? 163 PHE A CG  1 
ATOM   1235 C  CD1 . PHE A 1 163 ? 4.96393   9.45212   39.20428 1.000 37.88963  ? 163 PHE A CD1 1 
ATOM   1236 C  CD2 . PHE A 1 163 ? 3.54125   9.67031   41.11025 1.000 37.48072  ? 163 PHE A CD2 1 
ATOM   1237 C  CE1 . PHE A 1 163 ? 4.10768   10.23403  38.46558 1.000 34.24452  ? 163 PHE A CE1 1 
ATOM   1238 C  CE2 . PHE A 1 163 ? 2.67544   10.45721  40.36680 1.000 30.27663  ? 163 PHE A CE2 1 
ATOM   1239 C  CZ  . PHE A 1 163 ? 2.96617   10.73591  39.04741 1.000 35.15427  ? 163 PHE A CZ  1 
ATOM   1240 N  N   . GLY A 1 164 ? 7.87067   6.07555   41.08032 1.000 32.03213  ? 164 GLY A N   1 
ATOM   1241 C  CA  . GLY A 1 164 ? 8.98051   5.30833   41.60370 1.000 25.50461  ? 164 GLY A CA  1 
ATOM   1242 C  C   . GLY A 1 164 ? 10.19261  6.20207   41.74581 1.000 20.96602  ? 164 GLY A C   1 
ATOM   1243 O  O   . GLY A 1 164 ? 10.29677  7.24171   41.10451 1.000 27.87540  ? 164 GLY A O   1 
ATOM   1244 N  N   . VAL A 1 165 ? 11.09497  5.80159   42.63470 1.000 24.91551  ? 165 VAL A N   1 
ATOM   1245 C  CA  . VAL A 1 165 ? 12.38918  6.46061   42.77521 1.000 24.29553  ? 165 VAL A CA  1 
ATOM   1246 C  C   . VAL A 1 165 ? 13.40514  5.40531   43.18639 1.000 26.43232  ? 165 VAL A C   1 
ATOM   1247 O  O   . VAL A 1 165 ? 13.11829  4.52230   44.00156 1.000 25.78890  ? 165 VAL A O   1 
ATOM   1248 C  CB  . VAL A 1 165 ? 12.35766  7.62252   43.78328 1.000 26.70539  ? 165 VAL A CB  1 
ATOM   1249 C  CG1 . VAL A 1 165 ? 11.79595  7.15277   45.12521 1.000 22.16185  ? 165 VAL A CG1 1 
ATOM   1250 C  CG2 . VAL A 1 165 ? 13.76177  8.21952   43.94356 1.000 20.52556  ? 165 VAL A CG2 1 
ATOM   1251 N  N   . ILE A 1 166 ? 14.57781  5.46142   42.57038 1.000 21.49504  ? 166 ILE A N   1 
ATOM   1252 C  CA  . ILE A 1 166 ? 15.64618  4.53598   42.87545 1.000 24.28315  ? 166 ILE A CA  1 
ATOM   1253 C  C   . ILE A 1 166 ? 16.88667  5.36600   43.11028 1.000 23.92691  ? 166 ILE A C   1 
ATOM   1254 O  O   . ILE A 1 166 ? 17.21207  6.24615   42.31101 1.000 28.04724  ? 166 ILE A O   1 
ATOM   1255 C  CB  . ILE A 1 166 ? 15.86357  3.47220   41.76999 1.000 28.30555  ? 166 ILE A CB  1 
ATOM   1256 C  CG1 . ILE A 1 166 ? 17.13057  2.66790   42.04307 1.000 20.73387  ? 166 ILE A CG1 1 
ATOM   1257 C  CG2 . ILE A 1 166 ? 15.93166  4.09259   40.38993 1.000 22.90531  ? 166 ILE A CG2 1 
ATOM   1258 C  CD1 . ILE A 1 166 ? 17.25957  1.45702   41.16994 1.000 34.09201  ? 166 ILE A CD1 1 
ATOM   1259 N  N   . HIS A 1 167 ? 17.53985  5.11218   44.22999 1.000 27.56447  ? 167 HIS A N   1 
ATOM   1260 C  CA  . HIS A 1 167 ? 18.77853  5.74819   44.63559 1.000 24.13536  ? 167 HIS A CA  1 
ATOM   1261 C  C   . HIS A 1 167 ? 19.85366  4.67311   44.64913 1.000 25.98045  ? 167 HIS A C   1 
ATOM   1262 O  O   . HIS A 1 167 ? 19.69558  3.64803   45.32462 1.000 25.99998  ? 167 HIS A O   1 
ATOM   1263 C  CB  . HIS A 1 167 ? 18.63391  6.34808   46.03789 1.000 23.16647  ? 167 HIS A CB  1 
ATOM   1264 C  CG  . HIS A 1 167 ? 17.60571  7.42773   46.15122 1.000 25.31500  ? 167 HIS A CG  1 
ATOM   1265 N  ND1 . HIS A 1 167 ? 17.71842  8.63866   45.49906 1.000 26.13362  ? 167 HIS A ND1 1 
ATOM   1266 C  CD2 . HIS A 1 167 ? 16.45455  7.49291   46.86978 1.000 28.24053  ? 167 HIS A CD2 1 
ATOM   1267 C  CE1 . HIS A 1 167 ? 16.67442  9.39667   45.79553 1.000 29.61589  ? 167 HIS A CE1 1 
ATOM   1268 N  NE2 . HIS A 1 167 ? 15.89284  8.72667   46.62950 1.000 22.06171  ? 167 HIS A NE2 1 
ATOM   1269 N  N   . LEU A 1 168 ? 20.94801  4.89616   43.93443 1.000 27.68937  ? 168 LEU A N   1 
ATOM   1270 C  CA  . LEU A 1 168 ? 22.06827  3.96702   44.04580 1.000 23.25193  ? 168 LEU A CA  1 
ATOM   1271 C  C   . LEU A 1 168 ? 22.80257  4.20224   45.36383 1.000 23.72810  ? 168 LEU A C   1 
ATOM   1272 O  O   . LEU A 1 168 ? 23.31277  5.29610   45.60844 1.000 25.30471  ? 168 LEU A O   1 
ATOM   1273 C  CB  . LEU A 1 168 ? 23.02057  4.12456   42.87868 1.000 23.54018  ? 168 LEU A CB  1 
ATOM   1274 C  CG  . LEU A 1 168 ? 24.27195  3.26402   43.05528 1.000 30.20817  ? 168 LEU A CG  1 
ATOM   1275 C  CD1 . LEU A 1 168 ? 23.94813  1.81602   42.81366 1.000 24.56504  ? 168 LEU A CD1 1 
ATOM   1276 C  CD2 . LEU A 1 168 ? 25.41082  3.74647   42.13956 1.000 25.91697  ? 168 LEU A CD2 1 
ATOM   1277 N  N   . MET A 1 169 ? 22.87520  3.17464   46.20914 1.000 26.15633  ? 169 MET A N   1 
ATOM   1278 C  CA  . MET A 1 169 ? 23.60510  3.30319   47.46408 1.000 23.70730  ? 169 MET A CA  1 
ATOM   1279 C  C   . MET A 1 169 ? 25.05385  2.89991   47.31876 1.000 30.65344  ? 169 MET A C   1 
ATOM   1280 O  O   . MET A 1 169 ? 25.92957  3.50999   47.94386 1.000 28.76137  ? 169 MET A O   1 
ATOM   1281 C  CB  . MET A 1 169 ? 22.96878  2.44703   48.56744 1.000 28.03018  ? 169 MET A CB  1 
ATOM   1282 C  CG  . MET A 1 169 ? 21.58753  2.92808   49.03040 1.000 29.48887  ? 169 MET A CG  1 
ATOM   1283 S  SD  . MET A 1 169 ? 21.62935  4.58164   49.78852 1.000 34.02939  ? 169 MET A SD  1 
ATOM   1284 C  CE  . MET A 1 169 ? 20.99991  5.49935   48.41279 1.000 29.29340  ? 169 MET A CE  1 
ATOM   1285 N  N   . GLY A 1 170 ? 25.31995  1.86369   46.52827 1.000 30.15040  ? 170 GLY A N   1 
ATOM   1286 C  CA  . GLY A 1 170 ? 26.68301  1.41102   46.33562 1.000 36.79300  ? 170 GLY A CA  1 
ATOM   1287 C  C   . GLY A 1 170 ? 26.83510  0.50992   45.13372 1.000 32.31869  ? 170 GLY A C   1 
ATOM   1288 O  O   . GLY A 1 170 ? 25.91250  -0.21569  44.74512 1.000 37.71316  ? 170 GLY A O   1 
ATOM   1289 N  N   . ARG A 1 171 ? 28.03325  0.52130   44.57749 1.000 29.49197  ? 171 ARG A N   1 
ATOM   1290 C  CA  . ARG A 1 171 ? 28.41949  -0.35175  43.48034 1.000 34.19412  ? 171 ARG A CA  1 
ATOM   1291 C  C   . ARG A 1 171 ? 29.83022  -0.83911  43.75097 1.000 38.93615  ? 171 ARG A C   1 
ATOM   1292 O  O   . ARG A 1 171 ? 30.74041  -0.02995  43.96077 1.000 38.98714  ? 171 ARG A O   1 
ATOM   1293 C  CB  . ARG A 1 171 ? 28.37458  0.38436   42.14626 1.000 31.34877  ? 171 ARG A CB  1 
ATOM   1294 C  CG  . ARG A 1 171 ? 27.39863  -0.17057  41.19310 1.000 34.69729  ? 171 ARG A CG  1 
ATOM   1295 C  CD  . ARG A 1 171 ? 27.09875  0.86357   40.15662 1.000 35.09136  ? 171 ARG A CD  1 
ATOM   1296 N  NE  . ARG A 1 171 ? 27.28784  0.33020   38.81783 1.000 43.93783  ? 171 ARG A NE  1 
ATOM   1297 C  CZ  . ARG A 1 171 ? 28.45430  0.31407   38.19123 1.000 56.74694  ? 171 ARG A CZ  1 
ATOM   1298 N  NH1 . ARG A 1 171 ? 29.57058  0.73585   38.78651 1.000 53.00913  ? 171 ARG A NH1 1 
ATOM   1299 N  NH2 . ARG A 1 171 ? 28.50461  -0.13312  36.94110 1.000 47.47118  ? 171 ARG A NH2 1 
ATOM   1300 N  N   . PHE A 1 172 ? 30.02281  -2.14992  43.72254 1.000 32.26605  ? 172 PHE A N   1 
ATOM   1301 C  CA  . PHE A 1 172 ? 31.30135  -2.71657  44.12445 1.000 39.51648  ? 172 PHE A CA  1 
ATOM   1302 C  C   . PHE A 1 172 ? 31.71040  -3.75605  43.10079 1.000 30.09691  ? 172 PHE A C   1 
ATOM   1303 O  O   . PHE A 1 172 ? 31.01163  -4.76137  42.92612 1.000 29.11190  ? 172 PHE A O   1 
ATOM   1304 C  CB  . PHE A 1 172 ? 31.20899  -3.31874  45.53315 1.000 39.07262  ? 172 PHE A CB  1 
ATOM   1305 C  CG  . PHE A 1 172 ? 30.75370  -2.32763  46.57554 1.000 41.53125  ? 172 PHE A CG  1 
ATOM   1306 C  CD1 . PHE A 1 172 ? 31.66328  -1.47114  47.17284 1.000 40.31627  ? 172 PHE A CD1 1 
ATOM   1307 C  CD2 . PHE A 1 172 ? 29.41207  -2.24141  46.94783 1.000 44.52198  ? 172 PHE A CD2 1 
ATOM   1308 C  CE1 . PHE A 1 172 ? 31.25711  -0.55623  48.11410 1.000 42.36918  ? 172 PHE A CE1 1 
ATOM   1309 C  CE2 . PHE A 1 172 ? 28.99348  -1.32084  47.90651 1.000 36.53586  ? 172 PHE A CE2 1 
ATOM   1310 C  CZ  . PHE A 1 172 ? 29.91205  -0.47921  48.48228 1.000 37.91984  ? 172 PHE A CZ  1 
ATOM   1311 N  N   . ASN A 1 173 ? 32.83333  -3.49879  42.42537 1.000 28.94889  ? 173 ASN A N   1 
ATOM   1312 C  CA  . ASN A 1 173 ? 33.39768  -4.43251  41.46168 1.000 24.37974  ? 173 ASN A CA  1 
ATOM   1313 C  C   . ASN A 1 173 ? 32.36641  -4.78132  40.38890 1.000 31.77590  ? 173 ASN A C   1 
ATOM   1314 O  O   . ASN A 1 173 ? 32.25966  -5.92030  39.93602 1.000 33.56753  ? 173 ASN A O   1 
ATOM   1315 C  CB  . ASN A 1 173 ? 33.90575  -5.69090  42.17527 1.000 26.93152  ? 173 ASN A CB  1 
ATOM   1316 C  CG  . ASN A 1 173 ? 34.63396  -6.64837  41.24538 1.000 35.46977  ? 173 ASN A CG  1 
ATOM   1317 O  OD1 . ASN A 1 173 ? 35.49709  -6.24928  40.47132 1.000 35.13247  ? 173 ASN A OD1 1 
ATOM   1318 N  ND2 . ASN A 1 173 ? 34.25702  -7.91322  41.29820 1.000 36.09874  ? 173 ASN A ND2 1 
ATOM   1319 N  N   . ALA A 1 174 ? 31.56178  -3.80264  39.99606 1.000 31.23676  ? 174 ALA A N   1 
ATOM   1320 C  CA  . ALA A 1 174 ? 30.38188  -4.08198  39.18538 1.000 33.86610  ? 174 ALA A CA  1 
ATOM   1321 C  C   . ALA A 1 174 ? 30.50604  -3.42308  37.82041 1.000 42.04100  ? 174 ALA A C   1 
ATOM   1322 O  O   . ALA A 1 174 ? 30.74634  -2.21502  37.72101 1.000 48.00262  ? 174 ALA A O   1 
ATOM   1323 C  CB  . ALA A 1 174 ? 29.11369  -3.62409  39.89958 1.000 36.50342  ? 174 ALA A CB  1 
ATOM   1324 N  N   . ALA A 1 175 ? 30.39278  -4.22727  36.77936 1.000 37.55699  ? 175 ALA A N   1 
ATOM   1325 C  CA  . ALA A 1 175 ? 30.10507  -3.75528  35.43616 1.000 44.49333  ? 175 ALA A CA  1 
ATOM   1326 C  C   . ALA A 1 175 ? 28.67589  -4.15109  35.09055 1.000 41.06254  ? 175 ALA A C   1 
ATOM   1327 O  O   . ALA A 1 175 ? 28.06132  -4.96894  35.77598 1.000 33.57193  ? 175 ALA A O   1 
ATOM   1328 C  CB  . ALA A 1 175 ? 31.07954  -4.35493  34.42022 1.000 46.01366  ? 175 ALA A CB  1 
ATOM   1329 N  N   . GLY A 1 176 ? 28.15242  -3.59601  33.99714 1.000 44.96335  ? 176 GLY A N   1 
ATOM   1330 C  CA  . GLY A 1 176 ? 26.78054  -3.92681  33.67927 1.000 42.63552  ? 176 GLY A CA  1 
ATOM   1331 C  C   . GLY A 1 176 ? 25.83208  -3.19559  34.61599 1.000 38.20669  ? 176 GLY A C   1 
ATOM   1332 O  O   . GLY A 1 176 ? 26.15868  -2.15840  35.20671 1.000 32.12602  ? 176 GLY A O   1 
ATOM   1333 N  N   . GLY A 1 177 ? 24.63794  -3.74904  34.76315 1.000 39.46976  ? 177 GLY A N   1 
ATOM   1334 C  CA  . GLY A 1 177 ? 23.64131  -3.10917  35.60824 1.000 34.31085  ? 177 GLY A CA  1 
ATOM   1335 C  C   . GLY A 1 177 ? 23.06439  -1.83941  35.03774 1.000 28.83533  ? 177 GLY A C   1 
ATOM   1336 O  O   . GLY A 1 177 ? 22.77822  -0.90021  35.78936 1.000 34.36098  ? 177 GLY A O   1 
ATOM   1337 N  N   . GLU A 1 178 ? 22.87178  -1.79520  33.73152 1.000 32.82368  ? 178 GLU A N   1 
ATOM   1338 C  CA  . GLU A 1 178 ? 22.24522  -0.65739  33.07469 1.000 33.88723  ? 178 GLU A CA  1 
ATOM   1339 C  C   . GLU A 1 178 ? 20.73589  -0.70357  33.28983 1.000 34.52221  ? 178 GLU A C   1 
ATOM   1340 O  O   . GLU A 1 178 ? 20.11668  -1.75680  33.16621 1.000 28.32469  ? 178 GLU A O   1 
ATOM   1341 C  CB  . GLU A 1 178 ? 22.55420  -0.68100  31.57401 1.000 31.31791  ? 178 GLU A CB  1 
ATOM   1342 C  CG  . GLU A 1 178 ? 24.00913  -0.47268  31.20299 1.000 34.16217  ? 178 GLU A CG  1 
ATOM   1343 C  CD  . GLU A 1 178 ? 24.85601  -1.73807  31.28622 1.000 43.08937  ? 178 GLU A CD  1 
ATOM   1344 O  OE1 . GLU A 1 178 ? 24.37429  -2.79978  31.73619 1.000 38.77023  ? 178 GLU A OE1 1 
ATOM   1345 O  OE2 . GLU A 1 178 ? 26.03023  -1.65704  30.88144 1.000 54.35902  ? 178 GLU A OE2 1 
ATOM   1346 N  N   . SER A 1 179 ? 20.13432  0.43148   33.60778 1.000 27.26122  ? 179 SER A N   1 
ATOM   1347 C  CA  . SER A 1 179 ? 18.68648  0.48773   33.81603 1.000 37.02800  ? 179 SER A CA  1 
ATOM   1348 C  C   . SER A 1 179 ? 18.03386  0.76473   32.46548 1.000 36.11449  ? 179 SER A C   1 
ATOM   1349 O  O   . SER A 1 179 ? 18.44429  1.69028   31.75009 1.000 33.64795  ? 179 SER A O   1 
ATOM   1350 C  CB  . SER A 1 179 ? 18.30412  1.58732   34.82340 1.000 31.28998  ? 179 SER A CB  1 
ATOM   1351 O  OG  . SER A 1 179 ? 19.19190  1.65990   35.90074 1.000 25.08390  ? 179 SER A OG  1 
ATOM   1352 N  N   . GLN A 1 180 ? 17.00792  -0.00094  32.12293 1.000 31.96532  ? 180 GLN A N   1 
ATOM   1353 C  CA  . GLN A 1 180 ? 16.36639  0.14334   30.82041 1.000 40.43632  ? 180 GLN A CA  1 
ATOM   1354 C  C   . GLN A 1 180 ? 14.97233  0.73023   30.99238 1.000 36.59959  ? 180 GLN A C   1 
ATOM   1355 O  O   . GLN A 1 180 ? 14.20469  0.26707   31.84014 1.000 43.42298  ? 180 GLN A O   1 
ATOM   1356 C  CB  . GLN A 1 180 ? 16.29286  -1.19643  30.08840 1.000 28.83918  ? 180 GLN A CB  1 
ATOM   1357 C  CG  . GLN A 1 180 ? 17.56161  -1.97836  30.12729 1.000 35.04763  ? 180 GLN A CG  1 
ATOM   1358 C  CD  . GLN A 1 180 ? 17.77645  -2.76825  28.85156 1.000 51.22142  ? 180 GLN A CD  1 
ATOM   1359 O  OE1 . GLN A 1 180 ? 16.91747  -3.54817  28.45611 1.000 59.09216  ? 180 GLN A OE1 1 
ATOM   1360 N  NE2 . GLN A 1 180 ? 18.90959  -2.54667  28.18399 1.000 40.58000  ? 180 GLN A NE2 1 
ATOM   1361 N  N   . VAL A 1 181 ? 14.65248  1.74977   30.19498 1.000 37.96573  ? 181 VAL A N   1 
ATOM   1362 C  CA  . VAL A 1 181 ? 13.30158  2.29908   30.10415 1.000 33.75982  ? 181 VAL A CA  1 
ATOM   1363 C  C   . VAL A 1 181 ? 12.65253  1.78970   28.82144 1.000 38.01041  ? 181 VAL A C   1 
ATOM   1364 O  O   . VAL A 1 181 ? 13.18576  1.98886   27.72006 1.000 40.97693  ? 181 VAL A O   1 
ATOM   1365 C  CB  . VAL A 1 181 ? 13.31309  3.83575   30.13866 1.000 40.11640  ? 181 VAL A CB  1 
ATOM   1366 C  CG1 . VAL A 1 181 ? 11.86685  4.38853   30.08685 1.000 29.23494  ? 181 VAL A CG1 1 
ATOM   1367 C  CG2 . VAL A 1 181 ? 14.06178  4.34328   31.36980 1.000 31.40974  ? 181 VAL A CG2 1 
ATOM   1368 N  N   . TYR A 1 182 ? 11.49706  1.14707   28.96059 1.000 36.32098  ? 182 TYR A N   1 
ATOM   1369 C  CA  . TYR A 1 182 ? 10.74816  0.59422   27.84204 1.000 38.77778  ? 182 TYR A CA  1 
ATOM   1370 C  C   . TYR A 1 182 ? 9.41594   1.31030   27.67299 1.000 42.95701  ? 182 TYR A C   1 
ATOM   1371 O  O   . TYR A 1 182 ? 8.81042   1.77249   28.64223 1.000 37.27851  ? 182 TYR A O   1 
ATOM   1372 C  CB  . TYR A 1 182 ? 10.46973  -0.89786  28.03429 1.000 45.78977  ? 182 TYR A CB  1 
ATOM   1373 C  CG  . TYR A 1 182 ? 11.68890  -1.79483  27.94065 1.000 52.74847  ? 182 TYR A CG  1 
ATOM   1374 C  CD1 . TYR A 1 182 ? 12.47082  -2.06079  29.06632 1.000 39.95203  ? 182 TYR A CD1 1 
ATOM   1375 C  CD2 . TYR A 1 182 ? 12.04119  -2.39449  26.73660 1.000 40.97733  ? 182 TYR A CD2 1 
ATOM   1376 C  CE1 . TYR A 1 182 ? 13.56482  -2.88117  28.98665 1.000 41.56022  ? 182 TYR A CE1 1 
ATOM   1377 C  CE2 . TYR A 1 182 ? 13.13711  -3.21502  26.65196 1.000 42.06253  ? 182 TYR A CE2 1 
ATOM   1378 C  CZ  . TYR A 1 182 ? 13.89723  -3.44715  27.77404 1.000 51.20248  ? 182 TYR A CZ  1 
ATOM   1379 O  OH  . TYR A 1 182 ? 14.99142  -4.26328  27.68146 1.000 57.10103  ? 182 TYR A OH  1 
ATOM   1380 N  N   . SER A 1 183 ? 8.94501   1.37807   26.43249 1.000 49.62324  ? 183 SER A N   1 
ATOM   1381 C  CA  . SER A 1 183 ? 7.60774   1.90229   26.20985 1.000 45.24126  ? 183 SER A CA  1 
ATOM   1382 C  C   . SER A 1 183 ? 6.57321   0.88390   26.65991 1.000 41.81155  ? 183 SER A C   1 
ATOM   1383 O  O   . SER A 1 183 ? 6.88709   -0.27406  26.94940 1.000 39.34232  ? 183 SER A O   1 
ATOM   1384 C  CB  . SER A 1 183 ? 7.38846   2.23965   24.73817 1.000 46.47290  ? 183 SER A CB  1 
ATOM   1385 O  OG  . SER A 1 183 ? 7.20413   1.04229   23.99812 1.000 48.73699  ? 183 SER A OG  1 
ATOM   1386 N  N   . LEU A 1 184 ? 5.31311   1.31942   26.69010 1.000 44.18049  ? 184 LEU A N   1 
ATOM   1387 C  CA  . LEU A 1 184 ? 4.24576   0.39913   27.06609 1.000 44.47540  ? 184 LEU A CA  1 
ATOM   1388 C  C   . LEU A 1 184 ? 4.09529   -0.75745  26.08759 1.000 48.59514  ? 184 LEU A C   1 
ATOM   1389 O  O   . LEU A 1 184 ? 3.58735   -1.81147  26.47985 1.000 54.19442  ? 184 LEU A O   1 
ATOM   1390 C  CB  . LEU A 1 184 ? 2.93626   1.15653   27.19999 1.000 41.54549  ? 184 LEU A CB  1 
ATOM   1391 C  CG  . LEU A 1 184 ? 2.86992   1.92167   28.52336 1.000 54.04166  ? 184 LEU A CG  1 
ATOM   1392 C  CD1 . LEU A 1 184 ? 1.49963   2.52836   28.72602 1.000 44.34300  ? 184 LEU A CD1 1 
ATOM   1393 C  CD2 . LEU A 1 184 ? 3.26399   1.00551   29.69647 1.000 48.52179  ? 184 LEU A CD2 1 
ATOM   1394 N  N   . GLU A 1 185 ? 4.53963   -0.58737  24.82883 1.000 54.16139  ? 185 GLU A N   1 
ATOM   1395 C  CA  . GLU A 1 185 ? 4.64112   -1.64114  23.81969 1.000 55.86781  ? 185 GLU A CA  1 
ATOM   1396 C  C   . GLU A 1 185 ? 5.91222   -2.45722  23.93976 1.000 57.69986  ? 185 GLU A C   1 
ATOM   1397 O  O   . GLU A 1 185 ? 6.34345   -3.00675  22.91913 1.000 60.82009  ? 185 GLU A O   1 
ATOM   1398 C  CB  . GLU A 1 185 ? 4.57197   -1.04495  22.40849 1.000 56.94313  ? 185 GLU A CB  1 
ATOM   1399 C  CG  . GLU A 1 185 ? 3.34465   -0.20173  22.12778 1.000 56.83091  ? 185 GLU A CG  1 
ATOM   1400 C  CD  . GLU A 1 185 ? 3.47473   1.19709   22.66609 1.000 68.05047  ? 185 GLU A CD  1 
ATOM   1401 O  OE1 . GLU A 1 185 ? 4.44169   1.46733   23.40842 1.000 77.01909  ? 185 GLU A OE1 1 
ATOM   1402 O  OE2 . GLU A 1 185 ? 2.61216   2.03735   22.34830 1.000 84.97633  ? 185 GLU A OE2 1 
ATOM   1403 N  N   . ARG A 1 186 ? 6.52163   -2.51662  25.13242 1.000 49.41847  ? 186 ARG A N   1 
ATOM   1404 C  CA  . ARG A 1 186 ? 7.76316   -3.26312  25.37985 1.000 51.81533  ? 186 ARG A CA  1 
ATOM   1405 C  C   . ARG A 1 186 ? 8.88045   -2.92960  24.37535 1.000 50.36419  ? 186 ARG A C   1 
ATOM   1406 O  O   . ARG A 1 186 ? 9.63953   -3.80373  23.95348 1.000 49.89249  ? 186 ARG A O   1 
ATOM   1407 C  CB  . ARG A 1 186 ? 7.50023   -4.76791  25.38905 1.000 47.07896  ? 186 ARG A CB  1 
ATOM   1408 C  CG  . ARG A 1 186 ? 6.44318   -5.21074  26.34488 1.000 47.44248  ? 186 ARG A CG  1 
ATOM   1409 C  CD  . ARG A 1 186 ? 6.82683   -6.53352  26.98495 1.000 47.91349  ? 186 ARG A CD  1 
ATOM   1410 N  NE  . ARG A 1 186 ? 5.94967   -6.86701  28.10259 1.000 68.73304  ? 186 ARG A NE  1 
ATOM   1411 C  CZ  . ARG A 1 186 ? 6.22223   -7.77187  29.03588 1.000 78.15198  ? 186 ARG A CZ  1 
ATOM   1412 N  NH1 . ARG A 1 186 ? 7.37871   -8.42249  29.05797 1.000 62.76379  ? 186 ARG A NH1 1 
ATOM   1413 N  NH2 . ARG A 1 186 ? 5.31291   -8.02858  29.97458 1.000 82.71988  ? 186 ARG A NH2 1 
ATOM   1414 N  N   . GLU A 1 187 ? 9.02317   -1.65783  24.00933 1.000 46.15451  ? 187 GLU A N   1 
ATOM   1415 C  CA  . GLU A 1 187 ? 10.11905  -1.23797  23.14266 1.000 45.34140  ? 187 GLU A CA  1 
ATOM   1416 C  C   . GLU A 1 187 ? 11.13976  -0.40996  23.91378 1.000 51.37978  ? 187 GLU A C   1 
ATOM   1417 O  O   . GLU A 1 187 ? 10.77909  0.48809   24.68578 1.000 46.01337  ? 187 GLU A O   1 
ATOM   1418 C  CB  . GLU A 1 187 ? 9.60821   -0.43473  21.94390 1.000 59.00754  ? 187 GLU A CB  1 
ATOM   1419 C  CG  . GLU A 1 187 ? 10.43016  -0.63457  20.66448 1.000 64.32742  ? 187 GLU A CG  1 
ATOM   1420 C  CD  . GLU A 1 187 ? 10.40263  -2.08154  20.16772 1.000 76.08279  ? 187 GLU A CD  1 
ATOM   1421 O  OE1 . GLU A 1 187 ? 9.31810   -2.71548  20.20388 1.000 77.59341  ? 187 GLU A OE1 1 
ATOM   1422 O  OE2 . GLU A 1 187 ? 11.46884  -2.59414  19.75250 1.000 69.03114  ? 187 GLU A OE2 1 
ATOM   1423 N  N   . LEU A 1 188 ? 12.41691  -0.70214  23.67170 1.000 45.36680  ? 188 LEU A N   1 
ATOM   1424 C  CA  . LEU A 1 188 ? 13.50865  -0.04294  24.37588 1.000 40.35163  ? 188 LEU A CA  1 
ATOM   1425 C  C   . LEU A 1 188 ? 13.64326  1.40164   23.90703 1.000 46.23826  ? 188 LEU A C   1 
ATOM   1426 O  O   . LEU A 1 188 ? 13.90736  1.65737   22.72965 1.000 65.47909  ? 188 LEU A O   1 
ATOM   1427 C  CB  . LEU A 1 188 ? 14.80941  -0.81011  24.15424 1.000 32.97282  ? 188 LEU A CB  1 
ATOM   1428 C  CG  . LEU A 1 188 ? 16.03132  -0.31215  24.92455 1.000 43.76411  ? 188 LEU A CG  1 
ATOM   1429 C  CD1 . LEU A 1 188 ? 15.86844  -0.48987  26.44036 1.000 38.48490  ? 188 LEU A CD1 1 
ATOM   1430 C  CD2 . LEU A 1 188 ? 17.26442  -1.05053  24.41530 1.000 50.49029  ? 188 LEU A CD2 1 
ATOM   1431 N  N   . VAL A 1 189 ? 13.49974  2.34371   24.83539 1.000 43.15223  ? 189 VAL A N   1 
ATOM   1432 C  CA  . VAL A 1 189 ? 13.46874  3.77427   24.53639 1.000 37.74416  ? 189 VAL A CA  1 
ATOM   1433 C  C   . VAL A 1 189 ? 14.65394  4.49631   25.17523 1.000 47.66375  ? 189 VAL A C   1 
ATOM   1434 O  O   . VAL A 1 189 ? 15.16812  5.47919   24.61371 1.000 38.83656  ? 189 VAL A O   1 
ATOM   1435 C  CB  . VAL A 1 189 ? 12.13039  4.38513   25.00345 1.000 44.03869  ? 189 VAL A CB  1 
ATOM   1436 C  CG1 . VAL A 1 189 ? 12.26784  5.88633   25.26927 1.000 45.91749  ? 189 VAL A CG1 1 
ATOM   1437 C  CG2 . VAL A 1 189 ? 11.04833  4.11997   23.97973 1.000 42.75898  ? 189 VAL A CG2 1 
ATOM   1438 N  N   . ALA A 1 190 ? 15.08898  4.03395   26.35637 1.000 40.42190  ? 190 ALA A N   1 
ATOM   1439 C  CA  . ALA A 1 190 ? 16.23732  4.66592   26.99396 1.000 35.33707  ? 190 ALA A CA  1 
ATOM   1440 C  C   . ALA A 1 190 ? 17.00645  3.66592   27.83778 1.000 33.47417  ? 190 ALA A C   1 
ATOM   1441 O  O   . ALA A 1 190 ? 16.53734  2.56348   28.14237 1.000 33.64173  ? 190 ALA A O   1 
ATOM   1442 C  CB  . ALA A 1 190 ? 15.83939  5.86776   27.85305 1.000 27.58420  ? 190 ALA A CB  1 
ATOM   1443 N  N   . GLU A 1 191 ? 18.21911  4.07669   28.19068 1.000 33.52784  ? 191 GLU A N   1 
ATOM   1444 C  CA  . GLU A 1 191 ? 19.12374  3.26437   28.97982 1.000 38.52755  ? 191 GLU A CA  1 
ATOM   1445 C  C   . GLU A 1 191 ? 20.18472  4.19321   29.53947 1.000 33.79342  ? 191 GLU A C   1 
ATOM   1446 O  O   . GLU A 1 191 ? 20.68899  5.05959   28.82158 1.000 37.28047  ? 191 GLU A O   1 
ATOM   1447 C  CB  . GLU A 1 191 ? 19.75283  2.14441   28.14385 1.000 37.60915  ? 191 GLU A CB  1 
ATOM   1448 C  CG  . GLU A 1 191 ? 20.48323  1.12536   28.99073 1.000 40.74892  ? 191 GLU A CG  1 
ATOM   1449 C  CD  . GLU A 1 191 ? 21.44775  0.28722   28.17695 1.000 49.34288  ? 191 GLU A CD  1 
ATOM   1450 O  OE1 . GLU A 1 191 ? 22.61953  0.71729   28.01886 1.000 45.60581  ? 191 GLU A OE1 1 
ATOM   1451 O  OE2 . GLU A 1 191 ? 21.02143  -0.78694  27.69383 1.000 47.18013  ? 191 GLU A OE2 1 
ATOM   1452 N  N   . PHE A 1 192 ? 20.50075  4.01400   30.82040 1.000 29.56093  ? 192 PHE A N   1 
ATOM   1453 C  CA  . PHE A 1 192 ? 21.37144  4.90896   31.57711 1.000 27.68700  ? 192 PHE A CA  1 
ATOM   1454 C  C   . PHE A 1 192 ? 22.05503  4.09493   32.68593 1.000 31.73515  ? 192 PHE A C   1 
ATOM   1455 O  O   . PHE A 1 192 ? 21.74876  2.91518   32.92166 1.000 28.02846  ? 192 PHE A O   1 
ATOM   1456 C  CB  . PHE A 1 192 ? 20.58284  6.10317   32.14307 1.000 29.05178  ? 192 PHE A CB  1 
ATOM   1457 C  CG  . PHE A 1 192 ? 19.40501  5.70566   32.97827 1.000 34.21659  ? 192 PHE A CG  1 
ATOM   1458 C  CD1 . PHE A 1 192 ? 18.19249  5.38568   32.38486 1.000 39.74070  ? 192 PHE A CD1 1 
ATOM   1459 C  CD2 . PHE A 1 192 ? 19.51506  5.63029   34.36569 1.000 24.34517  ? 192 PHE A CD2 1 
ATOM   1460 C  CE1 . PHE A 1 192 ? 17.10829  4.99776   33.16431 1.000 38.08819  ? 192 PHE A CE1 1 
ATOM   1461 C  CE2 . PHE A 1 192 ? 18.46757  5.26153   35.12734 1.000 32.06604  ? 192 PHE A CE2 1 
ATOM   1462 C  CZ  . PHE A 1 192 ? 17.25007  4.92956   34.53362 1.000 34.68408  ? 192 PHE A CZ  1 
ATOM   1463 N  N   . CYS A 1 193 ? 22.99069  4.72434   33.37487 1.000 33.57160  ? 193 CYS A N   1 
ATOM   1464 C  CA  . CYS A 1 193 ? 23.82963  4.02132   34.33932 1.000 28.48843  ? 193 CYS A CA  1 
ATOM   1465 C  C   . CYS A 1 193 ? 23.84720  4.77400   35.65306 1.000 29.62269  ? 193 CYS A C   1 
ATOM   1466 O  O   . CYS A 1 193 ? 24.41897  5.86708   35.74263 1.000 29.26932  ? 193 CYS A O   1 
ATOM   1467 C  CB  . CYS A 1 193 ? 25.25187  3.87467   33.81369 1.000 33.83672  ? 193 CYS A CB  1 
ATOM   1468 S  SG  . CYS A 1 193 ? 25.32286  3.15265   32.19797 1.000 51.87585  ? 193 CYS A SG  1 
ATOM   1469 N  N   . LEU A 1 194 ? 23.25177  4.17807   36.67650 1.000 29.31185  ? 194 LEU A N   1 
ATOM   1470 C  CA  . LEU A 1 194 ? 23.55541  4.61965   38.02923 1.000 29.52894  ? 194 LEU A CA  1 
ATOM   1471 C  C   . LEU A 1 194 ? 24.93863  4.09357   38.39268 1.000 27.64834  ? 194 LEU A C   1 
ATOM   1472 O  O   . LEU A 1 194 ? 25.13211  2.87983   38.50997 1.000 27.77576  ? 194 LEU A O   1 
ATOM   1473 C  CB  . LEU A 1 194 ? 22.47612  4.14477   38.99555 1.000 30.48593  ? 194 LEU A CB  1 
ATOM   1474 C  CG  . LEU A 1 194 ? 21.05813  4.48122   38.50386 1.000 28.75735  ? 194 LEU A CG  1 
ATOM   1475 C  CD1 . LEU A 1 194 ? 20.04246  3.99581   39.48642 1.000 29.36942  ? 194 LEU A CD1 1 
ATOM   1476 C  CD2 . LEU A 1 194 ? 20.89936  5.95648   38.27392 1.000 22.56929  ? 194 LEU A CD2 1 
ATOM   1477 N  N   . THR A 1 195 ? 25.90656  5.00075   38.53468 1.000 26.96812  ? 195 THR A N   1 
ATOM   1478 C  CA  . THR A 1 195 ? 27.28833  4.64208   38.84791 1.000 30.19209  ? 195 THR A CA  1 
ATOM   1479 C  C   . THR A 1 195 ? 27.77756  5.16386   40.18961 1.000 27.05204  ? 195 THR A C   1 
ATOM   1480 O  O   . THR A 1 195 ? 28.50267  4.47141   40.88535 1.000 37.69889  ? 195 THR A O   1 
ATOM   1481 C  CB  . THR A 1 195 ? 28.21957  5.17684   37.76301 1.000 38.65873  ? 195 THR A CB  1 
ATOM   1482 O  OG1 . THR A 1 195 ? 28.02870  6.59589   37.64596 1.000 39.98000  ? 195 THR A OG1 1 
ATOM   1483 C  CG2 . THR A 1 195 ? 27.94298  4.49085   36.43261 1.000 41.81506  ? 195 THR A CG2 1 
ATOM   1484 N  N   . GLU A 1 196 ? 27.41301  6.36749   40.58122 1.000 34.17880  ? 196 GLU A N   1 
ATOM   1485 C  CA  . GLU A 1 196 ? 27.91709  6.96732   41.80539 1.000 33.22183  ? 196 GLU A CA  1 
ATOM   1486 C  C   . GLU A 1 196 ? 26.85638  6.92660   42.89709 1.000 28.77438  ? 196 GLU A C   1 
ATOM   1487 O  O   . GLU A 1 196 ? 25.65759  6.95439   42.62608 1.000 32.36708  ? 196 GLU A O   1 
ATOM   1488 C  CB  . GLU A 1 196 ? 28.33319  8.42372   41.57788 1.000 31.59331  ? 196 GLU A CB  1 
ATOM   1489 C  CG  . GLU A 1 196 ? 29.49256  8.60583   40.63964 1.000 46.68723  ? 196 GLU A CG  1 
ATOM   1490 C  CD  . GLU A 1 196 ? 29.92924  10.06150  40.55313 1.000 64.60766  ? 196 GLU A CD  1 
ATOM   1491 O  OE1 . GLU A 1 196 ? 29.32511  10.90982  41.25377 1.000 65.59619  ? 196 GLU A OE1 1 
ATOM   1492 O  OE2 . GLU A 1 196 ? 30.87793  10.36539  39.79133 1.000 72.46366  ? 196 GLU A OE2 1 
ATOM   1493 N  N   . GLN A 1 197 ? 27.30890  6.92112   44.13999 1.000 32.54675  ? 197 GLN A N   1 
ATOM   1494 C  CA  . GLN A 1 197 ? 26.39037  6.91742   45.27365 1.000 34.37961  ? 197 GLN A CA  1 
ATOM   1495 C  C   . GLN A 1 197 ? 25.44806  8.11931   45.23453 1.000 33.44339  ? 197 GLN A C   1 
ATOM   1496 O  O   . GLN A 1 197 ? 25.88768  9.26299   45.07021 1.000 30.50965  ? 197 GLN A O   1 
ATOM   1497 C  CB  . GLN A 1 197 ? 27.18820  6.90220   46.57606 1.000 32.61754  ? 197 GLN A CB  1 
ATOM   1498 C  CG  . GLN A 1 197 ? 26.35676  6.90755   47.84056 1.000 30.57469  ? 197 GLN A CG  1 
ATOM   1499 C  CD  . GLN A 1 197 ? 27.23867  6.70248   49.04306 1.000 32.37249  ? 197 GLN A CD  1 
ATOM   1500 O  OE1 . GLN A 1 197 ? 28.04940  7.57119   49.39814 1.000 30.16791  ? 197 GLN A OE1 1 
ATOM   1501 N  NE2 . GLN A 1 197 ? 27.12131  5.53454   49.65998 1.000 33.80750  ? 197 GLN A NE2 1 
ATOM   1502 N  N   . MET A 1 198 ? 24.15167  7.83553   45.41301 1.000 26.48927  ? 198 MET A N   1 
ATOM   1503 C  CA  . MET A 1 198 ? 23.00115  8.74171   45.36066 1.000 31.58194  ? 198 MET A CA  1 
ATOM   1504 C  C   . MET A 1 198 ? 22.62401  9.18537   43.94565 1.000 32.47170  ? 198 MET A C   1 
ATOM   1505 O  O   . MET A 1 198 ? 21.75000  10.06103  43.79924 1.000 31.97198  ? 198 MET A O   1 
ATOM   1506 C  CB  . MET A 1 198 ? 23.17395  9.97980   46.25072 1.000 26.37605  ? 198 MET A CB  1 
ATOM   1507 C  CG  . MET A 1 198 ? 23.03975  9.66222   47.74963 1.000 35.09105  ? 198 MET A CG  1 
ATOM   1508 S  SD  . MET A 1 198 ? 21.40571  9.06275   48.22180 1.000 36.37329  ? 198 MET A SD  1 
ATOM   1509 C  CE  . MET A 1 198 ? 20.38977  10.35247  47.56505 1.000 29.74122  ? 198 MET A CE  1 
ATOM   1510 N  N   . ASP A 1 199 ? 23.24686  8.62159   42.90186 1.000 24.73253  ? 199 ASP A N   1 
ATOM   1511 C  CA  . ASP A 1 199 ? 22.68982  8.73484   41.55952 1.000 23.95216  ? 199 ASP A CA  1 
ATOM   1512 C  C   . ASP A 1 199 ? 21.25122  8.26404   41.61520 1.000 26.76363  ? 199 ASP A C   1 
ATOM   1513 O  O   . ASP A 1 199 ? 20.95549  7.21582   42.19115 1.000 24.19208  ? 199 ASP A O   1 
ATOM   1514 C  CB  . ASP A 1 199 ? 23.46908  7.87910   40.52032 1.000 35.60820  ? 199 ASP A CB  1 
ATOM   1515 C  CG  . ASP A 1 199 ? 24.77247  8.52783   40.02071 1.000 27.36060  ? 199 ASP A CG  1 
ATOM   1516 O  OD1 . ASP A 1 199 ? 25.08269  9.69128   40.36754 1.000 32.13345  ? 199 ASP A OD1 1 
ATOM   1517 O  OD2 . ASP A 1 199 ? 25.48769  7.83967   39.25000 1.000 38.83633  ? 199 ASP A OD2 1 
ATOM   1518 N  N   . THR A 1 200 ? 20.36256  9.01271   40.97053 1.000 27.36089  ? 200 THR A N   1 
ATOM   1519 C  CA  . THR A 1 200 ? 18.95044  8.88139   41.26754 1.000 22.85824  ? 200 THR A CA  1 
ATOM   1520 C  C   . THR A 1 200 ? 18.13672  8.88057   39.99114 1.000 27.36284  ? 200 THR A C   1 
ATOM   1521 O  O   . THR A 1 200 ? 18.47999  9.54743   39.01750 1.000 33.83428  ? 200 THR A O   1 
ATOM   1522 C  CB  . THR A 1 200 ? 18.51353  10.00241  42.19751 1.000 23.21862  ? 200 THR A CB  1 
ATOM   1523 O  OG1 . THR A 1 200 ? 19.13955  9.80606   43.46523 1.000 22.47798  ? 200 THR A OG1 1 
ATOM   1524 C  CG2 . THR A 1 200 ? 16.99514  10.03063  42.37627 1.000 24.22328  ? 200 THR A CG2 1 
ATOM   1525 N  N   . MET A 1 201 ? 17.05159  8.12282   40.00742 1.000 27.07074  ? 201 MET A N   1 
ATOM   1526 C  CA  . MET A 1 201 ? 16.15638  8.05762   38.86784 1.000 28.24133  ? 201 MET A CA  1 
ATOM   1527 C  C   . MET A 1 201 ? 14.72163  8.02773   39.35736 1.000 27.33515  ? 201 MET A C   1 
ATOM   1528 O  O   . MET A 1 201 ? 14.36873  7.16048   40.16687 1.000 29.72722  ? 201 MET A O   1 
ATOM   1529 C  CB  . MET A 1 201 ? 16.43661  6.82143   38.02451 1.000 31.01436  ? 201 MET A CB  1 
ATOM   1530 C  CG  . MET A 1 201 ? 15.70933  6.86901   36.71458 1.000 36.20238  ? 201 MET A CG  1 
ATOM   1531 S  SD  . MET A 1 201 ? 14.22603  5.88924   36.72015 1.000 43.96621  ? 201 MET A SD  1 
ATOM   1532 C  CE  . MET A 1 201 ? 14.90042  4.24556   36.96107 1.000 37.18235  ? 201 MET A CE  1 
ATOM   1533 N  N   . PHE A 1 202 ? 13.90450  8.96378   38.86476 1.000 26.94682  ? 202 PHE A N   1 
ATOM   1534 C  CA  . PHE A 1 202 ? 12.47003  9.02831   39.14868 1.000 30.80733  ? 202 PHE A CA  1 
ATOM   1535 C  C   . PHE A 1 202 ? 11.68181  8.56512   37.93218 1.000 33.03088  ? 202 PHE A C   1 
ATOM   1536 O  O   . PHE A 1 202 ? 12.04109  8.89695   36.80383 1.000 29.87980  ? 202 PHE A O   1 
ATOM   1537 C  CB  . PHE A 1 202 ? 12.01127  10.44812  39.46817 1.000 24.35115  ? 202 PHE A CB  1 
ATOM   1538 C  CG  . PHE A 1 202 ? 12.87502  11.17867  40.44011 1.000 26.23571  ? 202 PHE A CG  1 
ATOM   1539 C  CD1 . PHE A 1 202 ? 12.72441  10.98790  41.81164 1.000 30.28895  ? 202 PHE A CD1 1 
ATOM   1540 C  CD2 . PHE A 1 202 ? 13.78964  12.11969  39.99830 1.000 28.91473  ? 202 PHE A CD2 1 
ATOM   1541 C  CE1 . PHE A 1 202 ? 13.51317  11.69935  42.72377 1.000 35.97418  ? 202 PHE A CE1 1 
ATOM   1542 C  CE2 . PHE A 1 202 ? 14.57442  12.84509  40.91513 1.000 30.82587  ? 202 PHE A CE2 1 
ATOM   1543 C  CZ  . PHE A 1 202 ? 14.44038  12.63157  42.26577 1.000 26.52762  ? 202 PHE A CZ  1 
ATOM   1544 N  N   . TRP A 1 203 ? 10.56726  7.86250   38.14848 1.000 32.04097  ? 203 TRP A N   1 
ATOM   1545 C  CA  . TRP A 1 203 ? 9.77521   7.44819   36.99528 1.000 29.45259  ? 203 TRP A CA  1 
ATOM   1546 C  C   . TRP A 1 203 ? 8.28543   7.42585   37.31297 1.000 36.59530  ? 203 TRP A C   1 
ATOM   1547 O  O   . TRP A 1 203 ? 7.86390   7.21445   38.45440 1.000 32.58409  ? 203 TRP A O   1 
ATOM   1548 C  CB  . TRP A 1 203 ? 10.22595  6.08637   36.46352 1.000 20.17016  ? 203 TRP A CB  1 
ATOM   1549 C  CG  . TRP A 1 203 ? 9.71671   4.84673   37.17782 1.000 24.58194  ? 203 TRP A CG  1 
ATOM   1550 C  CD1 . TRP A 1 203 ? 8.64342   4.07823   36.82500 1.000 20.59080  ? 203 TRP A CD1 1 
ATOM   1551 C  CD2 . TRP A 1 203 ? 10.31820  4.19907   38.31959 1.000 26.11233  ? 203 TRP A CD2 1 
ATOM   1552 N  NE1 . TRP A 1 203 ? 8.53382   2.99194   37.67852 1.000 25.99330  ? 203 TRP A NE1 1 
ATOM   1553 C  CE2 . TRP A 1 203 ? 9.53562   3.05533   38.61514 1.000 25.31026  ? 203 TRP A CE2 1 
ATOM   1554 C  CE3 . TRP A 1 203 ? 11.44354  4.47351   39.11228 1.000 24.23500  ? 203 TRP A CE3 1 
ATOM   1555 C  CZ2 . TRP A 1 203 ? 9.83276   2.19629   39.68424 1.000 29.67029  ? 203 TRP A CZ2 1 
ATOM   1556 C  CZ3 . TRP A 1 203 ? 11.73497  3.61533   40.17653 1.000 27.83922  ? 203 TRP A CZ3 1 
ATOM   1557 C  CH2 . TRP A 1 203 ? 10.93579  2.48426   40.44412 1.000 20.84877  ? 203 TRP A CH2 1 
ATOM   1558 N  N   . SER A 1 204 ? 7.49664   7.61717   36.26101 1.000 33.56302  ? 204 SER A N   1 
ATOM   1559 C  CA  . SER A 1 204 ? 6.04978   7.44443   36.30546 1.000 25.90473  ? 204 SER A CA  1 
ATOM   1560 C  C   . SER A 1 204 ? 5.73191   6.00136   35.92779 1.000 30.43267  ? 204 SER A C   1 
ATOM   1561 O  O   . SER A 1 204 ? 5.95321   5.58192   34.78696 1.000 36.42520  ? 204 SER A O   1 
ATOM   1562 C  CB  . SER A 1 204 ? 5.36640   8.43270   35.36873 1.000 31.05745  ? 204 SER A CB  1 
ATOM   1563 O  OG  . SER A 1 204 ? 5.74718   9.77542   35.64875 1.000 33.21055  ? 204 SER A OG  1 
ATOM   1564 N  N   . ASP A 1 205 ? 5.20621   5.24238   36.88571 1.000 32.21152  ? 205 ASP A N   1 
ATOM   1565 C  CA  . ASP A 1 205 ? 5.16532   3.79224   36.75702 1.000 37.53404  ? 205 ASP A CA  1 
ATOM   1566 C  C   . ASP A 1 205 ? 4.06209   3.28774   35.82282 1.000 34.29332  ? 205 ASP A C   1 
ATOM   1567 O  O   . ASP A 1 205 ? 4.08173   2.10865   35.45082 1.000 32.69063  ? 205 ASP A O   1 
ATOM   1568 C  CB  . ASP A 1 205 ? 5.02948   3.16038   38.14585 1.000 21.98365  ? 205 ASP A CB  1 
ATOM   1569 C  CG  . ASP A 1 205 ? 5.21091   1.66176   38.11357 1.000 29.82605  ? 205 ASP A CG  1 
ATOM   1570 O  OD1 . ASP A 1 205 ? 6.33501   1.20070   37.84048 1.000 36.61628  ? 205 ASP A OD1 1 
ATOM   1571 O  OD2 . ASP A 1 205 ? 4.23038   0.93740   38.34910 1.000 31.80278  ? 205 ASP A OD2 1 
ATOM   1572 N  N   . GLY A 1 206 ? 3.11276   4.12880   35.42882 1.000 37.44812  ? 206 GLY A N   1 
ATOM   1573 C  CA  . GLY A 1 206 ? 2.07462   3.67077   34.51850 1.000 38.02373  ? 206 GLY A CA  1 
ATOM   1574 C  C   . GLY A 1 206 ? 2.30817   4.16974   33.10646 1.000 41.03411  ? 206 GLY A C   1 
ATOM   1575 O  O   . GLY A 1 206 ? 1.58661   3.82002   32.16949 1.000 47.99076  ? 206 GLY A O   1 
ATOM   1576 N  N   . GLN A 1 207 ? 3.33884   4.99267   32.96051 1.000 45.45270  ? 207 GLN A N   1 
ATOM   1577 C  CA  . GLN A 1 207 ? 3.70355   5.64403   31.71640 1.000 40.57471  ? 207 GLN A CA  1 
ATOM   1578 C  C   . GLN A 1 207 ? 4.83425   4.93678   30.97398 1.000 45.73820  ? 207 GLN A C   1 
ATOM   1579 O  O   . GLN A 1 207 ? 4.95844   5.11602   29.75840 1.000 49.34844  ? 207 GLN A O   1 
ATOM   1580 C  CB  . GLN A 1 207 ? 4.07955   7.09636   32.03702 1.000 42.22230  ? 207 GLN A CB  1 
ATOM   1581 C  CG  . GLN A 1 207 ? 4.40322   8.00043   30.88655 1.000 46.23029  ? 207 GLN A CG  1 
ATOM   1582 C  CD  . GLN A 1 207 ? 4.28084   9.43791   31.31986 1.000 43.52887  ? 207 GLN A CD  1 
ATOM   1583 O  OE1 . GLN A 1 207 ? 3.50452   9.75396   32.22149 1.000 51.95491  ? 207 GLN A OE1 1 
ATOM   1584 N  NE2 . GLN A 1 207 ? 5.04721   10.31760  30.69818 1.000 39.64380  ? 207 GLN A NE2 1 
ATOM   1585 N  N   . ILE A 1 208 ? 5.64574   4.12374   31.65982 1.000 44.90863  ? 208 ILE A N   1 
ATOM   1586 C  CA  . ILE A 1 208 ? 6.75063   3.39821   31.03736 1.000 37.87435  ? 208 ILE A CA  1 
ATOM   1587 C  C   . ILE A 1 208 ? 6.80725   1.99421   31.62062 1.000 33.44887  ? 208 ILE A C   1 
ATOM   1588 O  O   . ILE A 1 208 ? 6.09968   1.65469   32.56479 1.000 41.07876  ? 208 ILE A O   1 
ATOM   1589 C  CB  . ILE A 1 208 ? 8.11643   4.09486   31.24016 1.000 36.81839  ? 208 ILE A CB  1 
ATOM   1590 C  CG1 . ILE A 1 208 ? 8.45469   4.17020   32.73779 1.000 35.11568  ? 208 ILE A CG1 1 
ATOM   1591 C  CG2 . ILE A 1 208 ? 8.12269   5.48835   30.61900 1.000 29.68050  ? 208 ILE A CG2 1 
ATOM   1592 C  CD1 . ILE A 1 208 ? 9.88664   4.51202   33.03628 1.000 26.13410  ? 208 ILE A CD1 1 
ATOM   1593 N  N   . LEU A 1 209 ? 7.65344   1.17379   31.03426 1.000 32.87096  ? 209 LEU A N   1 
ATOM   1594 C  CA  . LEU A 1 209 ? 8.08005   -0.07443  31.63818 1.000 36.04650  ? 209 LEU A CA  1 
ATOM   1595 C  C   . LEU A 1 209 ? 9.56765   0.04184   31.93268 1.000 37.01717  ? 209 LEU A C   1 
ATOM   1596 O  O   . LEU A 1 209 ? 10.25585  0.91881   31.41151 1.000 32.58376  ? 209 LEU A O   1 
ATOM   1597 C  CB  . LEU A 1 209 ? 7.82041   -1.28922  30.72341 1.000 37.30739  ? 209 LEU A CB  1 
ATOM   1598 C  CG  . LEU A 1 209 ? 6.37142   -1.63086  30.36107 1.000 44.77542  ? 209 LEU A CG  1 
ATOM   1599 C  CD1 . LEU A 1 209 ? 6.28781   -2.85580  29.45394 1.000 42.78085  ? 209 LEU A CD1 1 
ATOM   1600 C  CD2 . LEU A 1 209 ? 5.53066   -1.82309  31.61862 1.000 40.51063  ? 209 LEU A CD2 1 
ATOM   1601 N  N   . HIS A 1 210 ? 10.07776  -0.84443  32.77271 1.000 34.76597  ? 210 HIS A N   1 
ATOM   1602 C  CA  . HIS A 1 210 ? 11.46702  -0.69778  33.15510 1.000 36.39069  ? 210 HIS A CA  1 
ATOM   1603 C  C   . HIS A 1 210 ? 12.04904  -2.06386  33.47295 1.000 38.81600  ? 210 HIS A C   1 
ATOM   1604 O  O   . HIS A 1 210 ? 11.33042  -3.06152  33.59109 1.000 36.97017  ? 210 HIS A O   1 
ATOM   1605 C  CB  . HIS A 1 210 ? 11.60782  0.28432   34.33307 1.000 39.61202  ? 210 HIS A CB  1 
ATOM   1606 C  CG  . HIS A 1 210 ? 11.09606  -0.24705  35.63664 1.000 39.77429  ? 210 HIS A CG  1 
ATOM   1607 N  ND1 . HIS A 1 210 ? 9.84817   0.07071   36.12523 1.000 35.11972  ? 210 HIS A ND1 1 
ATOM   1608 C  CD2 . HIS A 1 210 ? 11.65774  -1.07979  36.54737 1.000 36.79625  ? 210 HIS A CD2 1 
ATOM   1609 C  CE1 . HIS A 1 210 ? 9.66552   -0.53939  37.28657 1.000 40.14385  ? 210 HIS A CE1 1 
ATOM   1610 N  NE2 . HIS A 1 210 ? 10.75141  -1.23684  37.56999 1.000 34.24388  ? 210 HIS A NE2 1 
ATOM   1611 N  N   . ALA A 1 211 ? 13.37236  -2.08570  33.60393 1.000 38.45383  ? 211 ALA A N   1 
ATOM   1612 C  CA  . ALA A 1 211 ? 14.14610  -3.29304  33.84453 1.000 34.62388  ? 211 ALA A CA  1 
ATOM   1613 C  C   . ALA A 1 211 ? 15.56799  -2.85353  34.13898 1.000 29.71634  ? 211 ALA A C   1 
ATOM   1614 O  O   . ALA A 1 211 ? 15.95024  -1.71549  33.85021 1.000 31.29081  ? 211 ALA A O   1 
ATOM   1615 C  CB  . ALA A 1 211 ? 14.11040  -4.23560  32.63697 1.000 32.92628  ? 211 ALA A CB  1 
ATOM   1616 N  N   . VAL A 1 212 ? 16.35210  -3.75495  34.70885 1.000 34.60330  ? 212 VAL A N   1 
ATOM   1617 C  CA  . VAL A 1 212 ? 17.77228  -3.50001  34.90413 1.000 35.30011  ? 212 VAL A CA  1 
ATOM   1618 C  C   . VAL A 1 212 ? 18.55135  -4.69651  34.37947 1.000 30.52996  ? 212 VAL A C   1 
ATOM   1619 O  O   . VAL A 1 212 ? 18.14171  -5.84978  34.55680 1.000 40.77579  ? 212 VAL A O   1 
ATOM   1620 C  CB  . VAL A 1 212 ? 18.12174  -3.20027  36.37891 1.000 38.44448  ? 212 VAL A CB  1 
ATOM   1621 C  CG1 . VAL A 1 212 ? 17.90144  -4.42252  37.26634 1.000 44.66582  ? 212 VAL A CG1 1 
ATOM   1622 C  CG2 . VAL A 1 212 ? 19.56838  -2.74180  36.48246 1.000 29.98192  ? 212 VAL A CG2 1 
ATOM   1623 N  N   . ARG A 1 213 ? 19.65516  -4.42170  33.70139 1.000 31.76009  ? 213 ARG A N   1 
ATOM   1624 C  CA  . ARG A 1 213 ? 20.50534  -5.49389  33.20592 1.000 42.33524  ? 213 ARG A CA  1 
ATOM   1625 C  C   . ARG A 1 213 ? 21.25382  -6.13919  34.36980 1.000 43.26918  ? 213 ARG A C   1 
ATOM   1626 O  O   . ARG A 1 213 ? 21.42006  -5.53406  35.43973 1.000 37.18205  ? 213 ARG A O   1 
ATOM   1627 C  CB  . ARG A 1 213 ? 21.49842  -4.97175  32.15930 1.000 36.78560  ? 213 ARG A CB  1 
ATOM   1628 C  CG  . ARG A 1 213 ? 20.88907  -4.67687  30.79117 1.000 35.14282  ? 213 ARG A CG  1 
ATOM   1629 C  CD  . ARG A 1 213 ? 21.94213  -4.75726  29.66587 1.000 47.18544  ? 213 ARG A CD  1 
ATOM   1630 N  NE  . ARG A 1 213 ? 21.47099  -4.17420  28.41156 1.000 49.90189  ? 213 ARG A NE  1 
ATOM   1631 C  CZ  . ARG A 1 213 ? 21.05261  -4.86935  27.36042 1.000 54.35964  ? 213 ARG A CZ  1 
ATOM   1632 N  NH1 . ARG A 1 213 ? 21.03674  -6.18994  27.36864 1.000 62.34017  ? 213 ARG A NH1 1 
ATOM   1633 N  NH2 . ARG A 1 213 ? 20.64728  -4.22169  26.26955 1.000 49.06197  ? 213 ARG A NH2 1 
ATOM   1634 N  N   . PRO A 1 214 ? 21.70341  -7.37768  34.19180 1.000 49.64921  ? 214 PRO A N   1 
ATOM   1635 C  CA  . PRO A 1 214 ? 22.49254  -8.01798  35.24537 1.000 38.66610  ? 214 PRO A CA  1 
ATOM   1636 C  C   . PRO A 1 214 ? 23.80653  -7.29066  35.43730 1.000 36.38820  ? 214 PRO A C   1 
ATOM   1637 O  O   . PRO A 1 214 ? 24.32308  -6.63226  34.52594 1.000 31.61268  ? 214 PRO A O   1 
ATOM   1638 C  CB  . PRO A 1 214 ? 22.71768  -9.43346  34.71430 1.000 37.34624  ? 214 PRO A CB  1 
ATOM   1639 C  CG  . PRO A 1 214 ? 21.62133  -9.63003  33.69268 1.000 43.89987  ? 214 PRO A CG  1 
ATOM   1640 C  CD  . PRO A 1 214 ? 21.41956  -8.29308  33.07615 1.000 34.31117  ? 214 PRO A CD  1 
ATOM   1641 N  N   . ILE A 1 215 ? 24.33087  -7.40992  36.63115 1.000 41.77562  ? 215 ILE A N   1 
ATOM   1642 C  CA  . ILE A 1 215 ? 25.69931  -6.99886  36.92173 1.000 45.79755  ? 215 ILE A CA  1 
ATOM   1643 C  C   . ILE A 1 215 ? 26.62133  -8.17686  36.63935 1.000 44.56131  ? 215 ILE A C   1 
ATOM   1644 O  O   . ILE A 1 215 ? 26.21741  -9.34595  36.72186 1.000 40.33650  ? 215 ILE A O   1 
ATOM   1645 C  CB  . ILE A 1 215 ? 25.84730  -6.50895  38.37910 1.000 35.19178  ? 215 ILE A CB  1 
ATOM   1646 C  CG1 . ILE A 1 215 ? 25.60460  -7.65471  39.35427 1.000 33.17176  ? 215 ILE A CG1 1 
ATOM   1647 C  CG2 . ILE A 1 215 ? 24.89372  -5.37510  38.66562 1.000 36.12469  ? 215 ILE A CG2 1 
ATOM   1648 C  CD1 . ILE A 1 215 ? 25.86536  -7.27410  40.83841 1.000 30.43399  ? 215 ILE A CD1 1 
ATOM   1649 N  N   . HIS A 1 216 ? 27.86985  -7.87939  36.30893 1.000 35.05746  ? 216 HIS A N   1 
ATOM   1650 C  CA  . HIS A 1 216 ? 28.89723  -8.90553  36.28061 1.000 44.15491  ? 216 HIS A CA  1 
ATOM   1651 C  C   . HIS A 1 216 ? 30.16000  -8.31117  36.92312 1.000 33.00977  ? 216 HIS A C   1 
ATOM   1652 O  O   . HIS A 1 216 ? 30.31982  -7.09819  36.94660 1.000 41.64158  ? 216 HIS A O   1 
ATOM   1653 C  CB  . HIS A 1 216 ? 29.16844  -9.43662  34.85907 1.000 29.40944  ? 216 HIS A CB  1 
ATOM   1654 C  CG  . HIS A 1 216 ? 29.59415  -8.39443  33.87577 1.000 48.44948  ? 216 HIS A CG  1 
ATOM   1655 N  ND1 . HIS A 1 216 ? 28.69872  -7.56055  33.23876 1.000 49.04400  ? 216 HIS A ND1 1 
ATOM   1656 C  CD2 . HIS A 1 216 ? 30.81829  -8.07601  33.38834 1.000 52.54146  ? 216 HIS A CD2 1 
ATOM   1657 C  CE1 . HIS A 1 216 ? 29.35561  -6.75776  32.41998 1.000 55.56758  ? 216 HIS A CE1 1 
ATOM   1658 N  NE2 . HIS A 1 216 ? 30.64241  -7.05405  32.48654 1.000 61.97631  ? 216 HIS A NE2 1 
ATOM   1659 N  N   . PRO A 1 217 ? 31.01452  -9.16503  37.47049 1.000 37.38923  ? 217 PRO A N   1 
ATOM   1660 C  CA  . PRO A 1 217 ? 32.20482  -8.63220  38.15577 1.000 35.44263  ? 217 PRO A CA  1 
ATOM   1661 C  C   . PRO A 1 217 ? 33.25805  -8.11971  37.18892 1.000 29.88980  ? 217 PRO A C   1 
ATOM   1662 O  O   . PRO A 1 217 ? 33.47907  -8.65989  36.10269 1.000 40.05136  ? 217 PRO A O   1 
ATOM   1663 C  CB  . PRO A 1 217 ? 32.71046  -9.83973  38.95476 1.000 32.66584  ? 217 PRO A CB  1 
ATOM   1664 C  CG  . PRO A 1 217 ? 32.22336  -11.01219 38.19602 1.000 41.89460  ? 217 PRO A CG  1 
ATOM   1665 C  CD  . PRO A 1 217 ? 30.90213  -10.62605 37.61567 1.000 40.37536  ? 217 PRO A CD  1 
ATOM   1666 N  N   . VAL A 1 218 ? 33.87460  -7.01258  37.58550 1.000 34.97527  ? 218 VAL A N   1 
ATOM   1667 C  CA  . VAL A 1 218 ? 35.01653  -6.49040  36.84608 1.000 42.12965  ? 218 VAL A CA  1 
ATOM   1668 C  C   . VAL A 1 218 ? 36.22088  -7.40321  37.05208 1.000 49.65060  ? 218 VAL A C   1 
ATOM   1669 O  O   . VAL A 1 218 ? 36.70699  -8.05017  36.11695 1.000 43.51544  ? 218 VAL A O   1 
ATOM   1670 C  CB  . VAL A 1 218 ? 35.32511  -5.04965  37.28126 1.000 38.01000  ? 218 VAL A CB  1 
ATOM   1671 C  CG1 . VAL A 1 218 ? 36.46525  -4.46128  36.42030 1.000 31.49150  ? 218 VAL A CG1 1 
ATOM   1672 C  CG2 . VAL A 1 218 ? 34.06027  -4.20575  37.20794 1.000 38.44173  ? 218 VAL A CG2 1 
ATOM   1673 N  N   . ASP A 1 219 ? 36.69699  -7.48445  38.28877 1.000 38.20878  ? 219 ASP A N   1 
ATOM   1674 C  CA  . ASP A 1 219 ? 37.60448  -8.53578  38.71511 1.000 37.30511  ? 219 ASP A CA  1 
ATOM   1675 C  C   . ASP A 1 219 ? 36.79625  -9.81380  38.89920 1.000 46.78719  ? 219 ASP A C   1 
ATOM   1676 O  O   . ASP A 1 219 ? 36.01233  -9.92125  39.84853 1.000 43.07533  ? 219 ASP A O   1 
ATOM   1677 C  CB  . ASP A 1 219 ? 38.30469  -8.11057  40.00398 1.000 37.04552  ? 219 ASP A CB  1 
ATOM   1678 C  CG  . ASP A 1 219 ? 39.25986  -9.14161  40.54229 1.000 43.73976  ? 219 ASP A CG  1 
ATOM   1679 O  OD1 . ASP A 1 219 ? 39.31441  -10.28498 40.04474 1.000 39.23954  ? 219 ASP A OD1 1 
ATOM   1680 O  OD2 . ASP A 1 219 ? 39.95279  -8.78835  41.51184 1.000 43.96168  ? 219 ASP A OD2 1 
ATOM   1681 N  N   . PRO A 1 220 ? 36.96892  -10.81071 38.02633 1.000 47.69815  ? 220 PRO A N   1 
ATOM   1682 C  CA  . PRO A 1 220 ? 36.12396  -12.01438 38.10146 1.000 41.81928  ? 220 PRO A CA  1 
ATOM   1683 C  C   . PRO A 1 220 ? 36.40429  -12.90150 39.30265 1.000 51.60440  ? 220 PRO A C   1 
ATOM   1684 O  O   . PRO A 1 220 ? 35.62675  -13.83427 39.54830 1.000 61.67907  ? 220 PRO A O   1 
ATOM   1685 C  CB  . PRO A 1 220 ? 36.43746  -12.75744 36.79587 1.000 43.12981  ? 220 PRO A CB  1 
ATOM   1686 C  CG  . PRO A 1 220 ? 37.41244  -11.87738 36.02999 1.000 51.79102  ? 220 PRO A CG  1 
ATOM   1687 C  CD  . PRO A 1 220 ? 38.01299  -10.91765 36.99766 1.000 41.98499  ? 220 PRO A CD  1 
ATOM   1688 N  N   . THR A 1 221 ? 37.48199  -12.66581 40.05123 1.000 47.51318  ? 221 THR A N   1 
ATOM   1689 C  CA  . THR A 1 221 ? 37.73816  -13.49368 41.22052 1.000 42.50821  ? 221 THR A CA  1 
ATOM   1690 C  C   . THR A 1 221 ? 36.91248  -13.07362 42.42423 1.000 51.87059  ? 221 THR A C   1 
ATOM   1691 O  O   . THR A 1 221 ? 36.84713  -13.81924 43.40697 1.000 60.83003  ? 221 THR A O   1 
ATOM   1692 C  CB  . THR A 1 221 ? 39.21583  -13.44111 41.60147 1.000 53.13601  ? 221 THR A CB  1 
ATOM   1693 O  OG1 . THR A 1 221 ? 39.45035  -12.28624 42.41197 1.000 47.32482  ? 221 THR A OG1 1 
ATOM   1694 C  CG2 . THR A 1 221 ? 40.10051  -13.39025 40.35023 1.000 40.45851  ? 221 THR A CG2 1 
ATOM   1695 N  N   . LYS A 1 222 ? 36.30182  -11.89802 42.37600 1.000 48.38780  ? 222 LYS A N   1 
ATOM   1696 C  CA  . LYS A 1 222 ? 35.53073  -11.35983 43.47785 1.000 52.49564  ? 222 LYS A CA  1 
ATOM   1697 C  C   . LYS A 1 222 ? 34.10236  -11.09027 43.02913 1.000 50.65327  ? 222 LYS A C   1 
ATOM   1698 O  O   . LYS A 1 222 ? 33.81689  -10.95575 41.83322 1.000 44.52790  ? 222 LYS A O   1 
ATOM   1699 C  CB  . LYS A 1 222 ? 36.17970  -10.08365 44.01475 1.000 46.96264  ? 222 LYS A CB  1 
ATOM   1700 C  CG  . LYS A 1 222 ? 37.66994  -10.12155 43.89990 1.000 52.35119  ? 222 LYS A CG  1 
ATOM   1701 C  CD  . LYS A 1 222 ? 38.30620  -8.98519  44.63129 1.000 52.17743  ? 222 LYS A CD  1 
ATOM   1702 C  CE  . LYS A 1 222 ? 39.03464  -9.46377  45.86376 1.000 39.95946  ? 222 LYS A CE  1 
ATOM   1703 N  NZ  . LYS A 1 222 ? 39.91251  -8.33420  46.28431 1.000 45.06105  ? 222 LYS A NZ  1 
ATOM   1704 N  N   . ALA A 1 223 ? 33.20135  -11.04210 44.00858 1.000 49.47217  ? 223 ALA A N   1 
ATOM   1705 C  CA  . ALA A 1 223 ? 31.80477  -10.77801 43.70491 1.000 51.56646  ? 223 ALA A CA  1 
ATOM   1706 C  C   . ALA A 1 223 ? 31.61925  -9.33950  43.23924 1.000 38.39570  ? 223 ALA A C   1 
ATOM   1707 O  O   . ALA A 1 223 ? 32.35253  -8.42671  43.63566 1.000 41.69205  ? 223 ALA A O   1 
ATOM   1708 C  CB  . ALA A 1 223 ? 30.92402  -11.04658 44.92108 1.000 44.79446  ? 223 ALA A CB  1 
ATOM   1709 N  N   . ALA A 1 224 ? 30.65582  -9.15568  42.35217 1.000 30.22225  ? 224 ALA A N   1 
ATOM   1710 C  CA  . ALA A 1 224 ? 30.13791  -7.83457  42.03040 1.000 37.81050  ? 224 ALA A CA  1 
ATOM   1711 C  C   . ALA A 1 224 ? 28.89798  -7.58552  42.88678 1.000 31.15765  ? 224 ALA A C   1 
ATOM   1712 O  O   . ALA A 1 224 ? 28.04903  -8.47351  43.01771 1.000 32.45593  ? 224 ALA A O   1 
ATOM   1713 C  CB  . ALA A 1 224 ? 29.79475  -7.74813  40.54643 1.000 31.89906  ? 224 ALA A CB  1 
ATOM   1714 N  N   . VAL A 1 225 ? 28.79803  -6.39069  43.46947 1.000 33.76254  ? 225 VAL A N   1 
ATOM   1715 C  CA  . VAL A 1 225 ? 27.70762  -6.02870  44.38248 1.000 34.24602  ? 225 VAL A CA  1 
ATOM   1716 C  C   . VAL A 1 225 ? 27.12194  -4.67288  43.99484 1.000 29.00353  ? 225 VAL A C   1 
ATOM   1717 O  O   . VAL A 1 225 ? 27.86731  -3.71895  43.75606 1.000 35.86941  ? 225 VAL A O   1 
ATOM   1718 C  CB  . VAL A 1 225 ? 28.20611  -5.98866  45.83660 1.000 33.53960  ? 225 VAL A CB  1 
ATOM   1719 C  CG1 . VAL A 1 225 ? 27.07881  -5.57011  46.75647 1.000 34.45651  ? 225 VAL A CG1 1 
ATOM   1720 C  CG2 . VAL A 1 225 ? 28.75902  -7.34574  46.23236 1.000 37.71720  ? 225 VAL A CG2 1 
ATOM   1721 N  N   . ARG A 1 226 ? 25.79050  -4.58220  43.95342 1.000 26.72212  ? 226 ARG A N   1 
ATOM   1722 C  CA  . ARG A 1 226 ? 25.07026  -3.35564  43.60700 1.000 23.15592  ? 226 ARG A CA  1 
ATOM   1723 C  C   . ARG A 1 226 ? 23.95871  -3.10482  44.62958 1.000 26.66673  ? 226 ARG A C   1 
ATOM   1724 O  O   . ARG A 1 226 ? 23.03565  -3.91606  44.74524 1.000 27.48152  ? 226 ARG A O   1 
ATOM   1725 C  CB  . ARG A 1 226 ? 24.48864  -3.46741  42.19020 1.000 20.03320  ? 226 ARG A CB  1 
ATOM   1726 C  CG  . ARG A 1 226 ? 23.65725  -2.28933  41.69745 1.000 19.40611  ? 226 ARG A CG  1 
ATOM   1727 C  CD  . ARG A 1 226 ? 23.27390  -2.45462  40.22105 1.000 24.37278  ? 226 ARG A CD  1 
ATOM   1728 N  NE  . ARG A 1 226 ? 22.67938  -1.24182  39.66369 1.000 28.27015  ? 226 ARG A NE  1 
ATOM   1729 C  CZ  . ARG A 1 226 ? 21.37013  -1.02265  39.57633 1.000 35.14199  ? 226 ARG A CZ  1 
ATOM   1730 N  NH1 . ARG A 1 226 ? 20.48822  -1.91237  40.00806 1.000 35.01855  ? 226 ARG A NH1 1 
ATOM   1731 N  NH2 . ARG A 1 226 ? 20.93196  0.11575   39.03789 1.000 32.73881  ? 226 ARG A NH2 1 
ATOM   1732 N  N   . ASP A 1 227 ? 24.03141  -1.97444  45.34917 1.000 27.73540  ? 227 ASP A N   1 
ATOM   1733 C  CA  . ASP A 1 227 ? 23.09634  -1.60831  46.42517 1.000 23.85867  ? 227 ASP A CA  1 
ATOM   1734 C  C   . ASP A 1 227 ? 22.18566  -0.46661  45.97269 1.000 29.26103  ? 227 ASP A C   1 
ATOM   1735 O  O   . ASP A 1 227 ? 22.66891  0.63257   45.65613 1.000 25.36725  ? 227 ASP A O   1 
ATOM   1736 C  CB  . ASP A 1 227 ? 23.84791  -1.15055  47.67594 1.000 28.91534  ? 227 ASP A CB  1 
ATOM   1737 C  CG  . ASP A 1 227 ? 24.62004  -2.27837  48.37694 1.000 25.71302  ? 227 ASP A CG  1 
ATOM   1738 O  OD1 . ASP A 1 227 ? 24.25368  -3.45609  48.21777 1.000 27.95730  ? 227 ASP A OD1 1 
ATOM   1739 O  OD2 . ASP A 1 227 ? 25.58192  -1.96999  49.11961 1.000 27.92423  ? 227 ASP A OD2 1 
ATOM   1740 N  N   . VAL A 1 228 ? 20.87603  -0.70024  45.96938 1.000 24.38577  ? 228 VAL A N   1 
ATOM   1741 C  CA  . VAL A 1 228 ? 19.92379  0.32049   45.54339 1.000 26.68568  ? 228 VAL A CA  1 
ATOM   1742 C  C   . VAL A 1 228 ? 18.80174  0.44855   46.56627 1.000 26.34429  ? 228 VAL A C   1 
ATOM   1743 O  O   . VAL A 1 228 ? 18.37268  -0.54462  47.16831 1.000 28.62599  ? 228 VAL A O   1 
ATOM   1744 C  CB  . VAL A 1 228 ? 19.35115  0.02369   44.14174 1.000 25.92285  ? 228 VAL A CB  1 
ATOM   1745 C  CG1 . VAL A 1 228 ? 20.48537  -0.08510  43.11221 1.000 23.52283  ? 228 VAL A CG1 1 
ATOM   1746 C  CG2 . VAL A 1 228 ? 18.47689  -1.22640  44.15289 1.000 27.32791  ? 228 VAL A CG2 1 
ATOM   1747 N  N   . LEU A 1 229 ? 18.35989  1.68583   46.79451 1.000 24.57933  ? 229 LEU A N   1 
ATOM   1748 C  CA  . LEU A 1 229 ? 17.15456  1.98195   47.55978 1.000 22.46950  ? 229 LEU A CA  1 
ATOM   1749 C  C   . LEU A 1 229 ? 16.05664  2.31833   46.56588 1.000 31.41373  ? 229 LEU A C   1 
ATOM   1750 O  O   . LEU A 1 229 ? 16.26303  3.14661   45.67077 1.000 26.85868  ? 229 LEU A O   1 
ATOM   1751 C  CB  . LEU A 1 229 ? 17.37877  3.14716   48.52536 1.000 24.23531  ? 229 LEU A CB  1 
ATOM   1752 C  CG  . LEU A 1 229 ? 16.21127  3.72280   49.35109 1.000 22.64779  ? 229 LEU A CG  1 
ATOM   1753 C  CD1 . LEU A 1 229 ? 15.68002  2.74600   50.36323 1.000 18.86328  ? 229 LEU A CD1 1 
ATOM   1754 C  CD2 . LEU A 1 229 ? 16.65400  5.00795   50.03820 1.000 22.04153  ? 229 LEU A CD2 1 
ATOM   1755 N  N   . ILE A 1 230 ? 14.91928  1.64006   46.68000 1.000 21.57157  ? 230 ILE A N   1 
ATOM   1756 C  CA  . ILE A 1 230 ? 13.80630  1.85162   45.76861 1.000 22.14090  ? 230 ILE A CA  1 
ATOM   1757 C  C   . ILE A 1 230 ? 12.57986  2.22809   46.57919 1.000 24.08235  ? 230 ILE A C   1 
ATOM   1758 O  O   . ILE A 1 230 ? 12.25652  1.55400   47.56509 1.000 25.21732  ? 230 ILE A O   1 
ATOM   1759 C  CB  . ILE A 1 230 ? 13.50261  0.61690   44.90219 1.000 26.95867  ? 230 ILE A CB  1 
ATOM   1760 C  CG1 . ILE A 1 230 ? 14.72104  0.21384   44.08809 1.000 23.19628  ? 230 ILE A CG1 1 
ATOM   1761 C  CG2 . ILE A 1 230 ? 12.30457  0.91342   43.93577 1.000 20.28147  ? 230 ILE A CG2 1 
ATOM   1762 C  CD1 . ILE A 1 230 ? 14.39008  -0.80553  42.96872 1.000 28.27845  ? 230 ILE A CD1 1 
ATOM   1763 N  N   . MET A 1 231 ? 11.88108  3.28368   46.15232 1.000 20.03604  ? 231 MET A N   1 
ATOM   1764 C  CA  . MET A 1 231 ? 10.60474  3.62490   46.75974 1.000 23.19486  ? 231 MET A CA  1 
ATOM   1765 C  C   . MET A 1 231 ? 9.50145   3.72404   45.71077 1.000 19.64945  ? 231 MET A C   1 
ATOM   1766 O  O   . MET A 1 231 ? 9.72000   4.22517   44.60102 1.000 22.08929  ? 231 MET A O   1 
ATOM   1767 C  CB  . MET A 1 231 ? 10.75265  4.90841   47.59210 1.000 23.48255  ? 231 MET A CB  1 
ATOM   1768 C  CG  . MET A 1 231 ? 11.53612  4.64047   48.87608 1.000 17.22680  ? 231 MET A CG  1 
ATOM   1769 S  SD  . MET A 1 231 ? 11.66213  6.03309   50.00617 1.000 31.93028  ? 231 MET A SD  1 
ATOM   1770 C  CE  . MET A 1 231 ? 12.75856  7.11544   49.09178 1.000 24.56677  ? 231 MET A CE  1 
ATOM   1771 N  N   . GLY A 1 232 ? 8.31878   3.21219   46.05543 1.000 22.56135  ? 232 GLY A N   1 
ATOM   1772 C  CA  . GLY A 1 232 ? 7.18429   3.22888   45.14355 1.000 22.56870  ? 232 GLY A CA  1 
ATOM   1773 C  C   . GLY A 1 232 ? 5.97327   3.90322   45.75536 1.000 26.91540  ? 232 GLY A C   1 
ATOM   1774 O  O   . GLY A 1 232 ? 5.47606   3.45496   46.78845 1.000 24.69054  ? 232 GLY A O   1 
ATOM   1775 N  N   . TYR A 1 233 ? 5.49276   4.98560   45.14530 1.000 25.18405  ? 233 TYR A N   1 
ATOM   1776 C  CA  . TYR A 1 233 ? 4.42728   5.80505   45.71619 1.000 33.56871  ? 233 TYR A CA  1 
ATOM   1777 C  C   . TYR A 1 233 ? 3.11180   5.46561   45.02836 1.000 36.57861  ? 233 TYR A C   1 
ATOM   1778 O  O   . TYR A 1 233 ? 2.98002   5.63710   43.81460 1.000 36.92393  ? 233 TYR A O   1 
ATOM   1779 C  CB  . TYR A 1 233 ? 4.71723   7.30274   45.57075 1.000 28.47110  ? 233 TYR A CB  1 
ATOM   1780 C  CG  . TYR A 1 233 ? 5.93731   7.82735   46.32052 1.000 25.12189  ? 233 TYR A CG  1 
ATOM   1781 C  CD1 . TYR A 1 233 ? 7.21664   7.55618   45.86172 1.000 24.20619  ? 233 TYR A CD1 1 
ATOM   1782 C  CD2 . TYR A 1 233 ? 5.81105   8.59635   47.46932 1.000 22.06636  ? 233 TYR A CD2 1 
ATOM   1783 C  CE1 . TYR A 1 233 ? 8.33441   8.02959   46.51731 1.000 24.43326  ? 233 TYR A CE1 1 
ATOM   1784 C  CE2 . TYR A 1 233 ? 6.94220   9.06569   48.14222 1.000 24.16706  ? 233 TYR A CE2 1 
ATOM   1785 C  CZ  . TYR A 1 233 ? 8.20745   8.77399   47.64984 1.000 22.03249  ? 233 TYR A CZ  1 
ATOM   1786 O  OH  . TYR A 1 233 ? 9.36942   9.23147   48.24921 1.000 22.31126  ? 233 TYR A OH  1 
ATOM   1787 N  N   . LYS A 1 234 ? 2.14187   4.99858   45.80474 1.000 27.47321  ? 234 LYS A N   1 
ATOM   1788 C  CA  . LYS A 1 234 ? 0.82208   4.65925   45.29527 1.000 36.98772  ? 234 LYS A CA  1 
ATOM   1789 C  C   . LYS A 1 234 ? -0.21173  5.51236   46.01896 1.000 36.54694  ? 234 LYS A C   1 
ATOM   1790 O  O   . LYS A 1 234 ? -0.32847  5.43851   47.24455 1.000 39.96507  ? 234 LYS A O   1 
ATOM   1791 C  CB  . LYS A 1 234 ? 0.53039   3.16979   45.48632 1.000 33.42783  ? 234 LYS A CB  1 
ATOM   1792 C  CG  . LYS A 1 234 ? -0.61559  2.67006   44.65589 1.000 29.71654  ? 234 LYS A CG  1 
ATOM   1793 C  CD  . LYS A 1 234 ? -0.89842  1.19485   44.90488 1.000 39.55780  ? 234 LYS A CD  1 
ATOM   1794 C  CE  . LYS A 1 234 ? -2.14089  0.77547   44.12229 1.000 48.09715  ? 234 LYS A CE  1 
ATOM   1795 N  NZ  . LYS A 1 234 ? -2.55993  1.91185   43.23378 1.000 53.65291  ? 234 LYS A NZ  1 
ATOM   1796 N  N   . HIS A 1 235 ? -0.93058  6.34237   45.26735 1.000 37.38737  ? 235 HIS A N   1 
ATOM   1797 C  CA  . HIS A 1 235 ? -2.06498  7.09347   45.80976 1.000 44.19723  ? 235 HIS A CA  1 
ATOM   1798 C  C   . HIS A 1 235 ? -3.12116  6.14791   46.40041 1.000 44.15658  ? 235 HIS A C   1 
ATOM   1799 O  O   . HIS A 1 235 ? -3.69168  5.31895   45.68427 1.000 39.94190  ? 235 HIS A O   1 
ATOM   1800 C  CB  . HIS A 1 235 ? -2.65014  7.93950   44.68947 1.000 34.32860  ? 235 HIS A CB  1 
ATOM   1801 C  CG  . HIS A 1 235 ? -3.80825  8.78371   45.09406 1.000 48.76641  ? 235 HIS A CG  1 
ATOM   1802 N  ND1 . HIS A 1 235 ? -5.03757  8.69510   44.47755 1.000 44.52552  ? 235 HIS A ND1 1 
ATOM   1803 C  CD2 . HIS A 1 235 ? -3.91522  9.77465   46.00962 1.000 50.29850  ? 235 HIS A CD2 1 
ATOM   1804 C  CE1 . HIS A 1 235 ? -5.86338  9.56960   45.02278 1.000 55.69952  ? 235 HIS A CE1 1 
ATOM   1805 N  NE2 . HIS A 1 235 ? -5.20594  10.24219  45.95024 1.000 51.61399  ? 235 HIS A NE2 1 
ATOM   1806 N  N   . GLU A 1 236 ? -3.35157  6.24016   47.71758 1.000 30.93152  ? 236 GLU A N   1 
ATOM   1807 C  CA  . GLU A 1 236 ? -4.31452  5.38008   48.42257 1.000 49.97415  ? 236 GLU A CA  1 
ATOM   1808 C  C   . GLU A 1 236 ? -5.31767  6.20450   49.21989 1.000 47.73341  ? 236 GLU A C   1 
ATOM   1809 O  O   . GLU A 1 236 ? -5.17485  6.34531   50.44191 1.000 43.66836  ? 236 GLU A O   1 
ATOM   1810 C  CB  . GLU A 1 236 ? -3.62846  4.42249   49.40117 1.000 44.89769  ? 236 GLU A CB  1 
ATOM   1811 C  CG  . GLU A 1 236 ? -2.70886  3.37824   48.82787 1.000 46.23985  ? 236 GLU A CG  1 
ATOM   1812 C  CD  . GLU A 1 236 ? -3.44385  2.24467   48.15328 1.000 61.18717  ? 236 GLU A CD  1 
ATOM   1813 O  OE1 . GLU A 1 236 ? -4.70090  2.22613   48.20503 1.000 68.47026  ? 236 GLU A OE1 1 
ATOM   1814 O  OE2 . GLU A 1 236 ? -2.75573  1.37587   47.55792 1.000 49.58406  ? 236 GLU A OE2 1 
ATOM   1815 N  N   . PRO A 1 237 ? -6.37365  6.71498   48.57788 1.000 44.58795  ? 237 PRO A N   1 
ATOM   1816 C  CA  . PRO A 1 237 ? -7.32231  7.57956   49.30712 1.000 46.62389  ? 237 PRO A CA  1 
ATOM   1817 C  C   . PRO A 1 237 ? -8.15780  6.85462   50.34539 1.000 45.09562  ? 237 PRO A C   1 
ATOM   1818 O  O   . PRO A 1 237 ? -8.66603  7.51333   51.25056 1.000 46.15287  ? 237 PRO A O   1 
ATOM   1819 C  CB  . PRO A 1 237 ? -8.19983  8.17581   48.19702 1.000 48.44887  ? 237 PRO A CB  1 
ATOM   1820 C  CG  . PRO A 1 237 ? -7.99937  7.27944   47.01497 1.000 57.21839  ? 237 PRO A CG  1 
ATOM   1821 C  CD  . PRO A 1 237 ? -6.63589  6.67289   47.13092 1.000 45.27064  ? 237 PRO A CD  1 
ATOM   1822 N  N   . GLU A 1 238 ? -8.30319  5.53666   50.26691 1.000 56.33041  ? 238 GLU A N   1 
ATOM   1823 C  CA  . GLU A 1 238 ? -9.05429  4.78816   51.26546 1.000 47.80871  ? 238 GLU A CA  1 
ATOM   1824 C  C   . GLU A 1 238 ? -8.20671  4.34535   52.45072 1.000 62.91790  ? 238 GLU A C   1 
ATOM   1825 O  O   . GLU A 1 238 ? -8.76854  3.86479   53.44442 1.000 57.14100  ? 238 GLU A O   1 
ATOM   1826 C  CB  . GLU A 1 238 ? -9.71053  3.55220   50.62791 1.000 61.70959  ? 238 GLU A CB  1 
ATOM   1827 C  CG  . GLU A 1 238 ? -10.79879 3.85173   49.58044 1.000 74.83632  ? 238 GLU A CG  1 
ATOM   1828 C  CD  . GLU A 1 238 ? -12.06873 4.44200   50.18939 1.000 89.03081  ? 238 GLU A CD  1 
ATOM   1829 O  OE1 . GLU A 1 238 ? -12.79328 3.70766   50.90456 1.000 80.10661  ? 238 GLU A OE1 1 
ATOM   1830 O  OE2 . GLU A 1 238 ? -12.33918 5.64403   49.95745 1.000 96.47010  ? 238 GLU A OE2 1 
ATOM   1831 N  N   . LEU A 1 239 ? -6.88098  4.47361   52.36951 1.000 53.83660  ? 239 LEU A N   1 
ATOM   1832 C  CA  . LEU A 1 239 ? -6.01853  3.97669   53.43506 1.000 52.76153  ? 239 LEU A CA  1 
ATOM   1833 C  C   . LEU A 1 239 ? -6.21586  4.79297   54.71503 1.000 49.66517  ? 239 LEU A C   1 
ATOM   1834 O  O   . LEU A 1 239 ? -6.27345  6.02567   54.68323 1.000 52.94075  ? 239 LEU A O   1 
ATOM   1835 C  CB  . LEU A 1 239 ? -4.55585  4.01477   52.97425 1.000 45.83983  ? 239 LEU A CB  1 
ATOM   1836 C  CG  . LEU A 1 239 ? -3.44443  3.59575   53.95051 1.000 50.97179  ? 239 LEU A CG  1 
ATOM   1837 C  CD1 . LEU A 1 239 ? -3.52331  2.11408   54.30618 1.000 45.31135  ? 239 LEU A CD1 1 
ATOM   1838 C  CD2 . LEU A 1 239 ? -2.07208  3.95049   53.38935 1.000 41.90406  ? 239 LEU A CD2 1 
ATOM   1839 N  N   . ARG A 1 240 ? -6.34760  4.09935   55.84221 1.000 49.21373  ? 240 ARG A N   1 
ATOM   1840 C  CA  . ARG A 1 240 ? -6.54645  4.73073   57.14322 1.000 62.04684  ? 240 ARG A CA  1 
ATOM   1841 C  C   . ARG A 1 240 ? -5.30769  4.53904   58.01124 1.000 60.29274  ? 240 ARG A C   1 
ATOM   1842 O  O   . ARG A 1 240 ? -4.47215  3.66872   57.74234 1.000 52.56116  ? 240 ARG A O   1 
ATOM   1843 C  CB  . ARG A 1 240 ? -7.77339  4.15292   57.86229 1.000 60.65861  ? 240 ARG A CB  1 
ATOM   1844 C  CG  . ARG A 1 240 ? -9.05657  4.22447   57.05852 1.000 60.92511  ? 240 ARG A CG  1 
ATOM   1845 C  CD  . ARG A 1 240 ? -10.19914 3.49461   57.74066 1.000 73.05418  ? 240 ARG A CD  1 
ATOM   1846 N  NE  . ARG A 1 240 ? -11.14900 4.41098   58.36576 1.000 81.07884  ? 240 ARG A NE  1 
ATOM   1847 C  CZ  . ARG A 1 240 ? -11.25154 4.61360   59.67452 1.000 87.59774  ? 240 ARG A CZ  1 
ATOM   1848 N  NH1 . ARG A 1 240 ? -10.47386 3.97733   60.53893 1.000 82.27948  ? 240 ARG A NH1 1 
ATOM   1849 N  NH2 . ARG A 1 240 ? -12.16262 5.47043   60.13036 1.000 90.59607  ? 240 ARG A NH2 1 
ATOM   1850 N  N   . ARG A 1 241 ? -5.18791  5.36154   59.05868 1.000 50.84896  ? 241 ARG A N   1 
ATOM   1851 C  CA  . ARG A 1 241 ? -4.04679  5.21576   59.94754 1.000 40.62558  ? 241 ARG A CA  1 
ATOM   1852 C  C   . ARG A 1 241 ? -4.10288  3.86182   60.65017 1.000 57.58758  ? 241 ARG A C   1 
ATOM   1853 O  O   . ARG A 1 241 ? -5.17247  3.28214   60.86307 1.000 53.13596  ? 241 ARG A O   1 
ATOM   1854 C  CB  . ARG A 1 241 ? -3.98518  6.36505   60.96035 1.000 47.38721  ? 241 ARG A CB  1 
ATOM   1855 C  CG  . ARG A 1 241 ? -3.61473  7.72833   60.34990 1.000 51.74114  ? 241 ARG A CG  1 
ATOM   1856 C  CD  . ARG A 1 241 ? -3.50364  8.87719   61.38238 1.000 45.40745  ? 241 ARG A CD  1 
ATOM   1857 N  NE  . ARG A 1 241 ? -2.86046  10.06317  60.81476 1.000 50.64081  ? 241 ARG A NE  1 
ATOM   1858 C  CZ  . ARG A 1 241 ? -3.49483  11.01041  60.13156 1.000 55.03778  ? 241 ARG A CZ  1 
ATOM   1859 N  NH1 . ARG A 1 241 ? -4.80809  10.98431  59.96573 1.000 60.21017  ? 241 ARG A NH1 1 
ATOM   1860 N  NH2 . ARG A 1 241 ? -2.79398  12.00362  59.59030 1.000 51.00579  ? 241 ARG A NH2 1 
ATOM   1861 N  N   . GLU A 1 242 ? -2.92300  3.34090   60.96650 1.000 61.51491  ? 242 GLU A N   1 
ATOM   1862 C  CA  . GLU A 1 242 ? -2.75484  2.08286   61.67518 1.000 52.85138  ? 242 GLU A CA  1 
ATOM   1863 C  C   . GLU A 1 242 ? -1.83361  2.32513   62.86450 1.000 51.26637  ? 242 GLU A C   1 
ATOM   1864 O  O   . GLU A 1 242 ? -1.14039  3.34476   62.93959 1.000 55.28828  ? 242 GLU A O   1 
ATOM   1865 C  CB  . GLU A 1 242 ? -2.15970  0.99967   60.75880 1.000 50.92665  ? 242 GLU A CB  1 
ATOM   1866 C  CG  . GLU A 1 242 ? -2.94018  0.73394   59.47502 1.000 56.64682  ? 242 GLU A CG  1 
ATOM   1867 C  CD  . GLU A 1 242 ? -2.08074  0.03484   58.40694 1.000 51.16734  ? 242 GLU A CD  1 
ATOM   1868 O  OE1 . GLU A 1 242 ? -1.13679  0.65243   57.89185 1.000 51.13897  ? 242 GLU A OE1 1 
ATOM   1869 O  OE2 . GLU A 1 242 ? -2.34876  -1.14108  58.08903 1.000 39.35821  ? 242 GLU A OE2 1 
ATOM   1870 N  N   . GLU A 1 243 ? -1.81223  1.38082   63.79650 1.000 49.27367  ? 243 GLU A N   1 
ATOM   1871 C  CA  . GLU A 1 243 ? -0.97762  1.56136   64.97895 1.000 67.21138  ? 243 GLU A CA  1 
ATOM   1872 C  C   . GLU A 1 243 ? 0.50754   1.39761   64.63973 1.000 64.89770  ? 243 GLU A C   1 
ATOM   1873 O  O   . GLU A 1 243 ? 0.89375   0.60626   63.77469 1.000 61.62106  ? 243 GLU A O   1 
ATOM   1874 C  CB  . GLU A 1 243 ? -1.38831  0.58393   66.08010 1.000 61.22640  ? 243 GLU A CB  1 
ATOM   1875 C  CG  . GLU A 1 243 ? -2.88941  0.61843   66.41545 1.000 80.26255  ? 243 GLU A CG  1 
ATOM   1876 C  CD  . GLU A 1 243 ? -3.33990  1.88838   67.15308 1.000 99.39776  ? 243 GLU A CD  1 
ATOM   1877 O  OE1 . GLU A 1 243 ? -2.48368  2.71240   67.55425 1.000 97.81144  ? 243 GLU A OE1 1 
ATOM   1878 O  OE2 . GLU A 1 243 ? -4.56775  2.05474   67.34134 1.000 106.85750 ? 243 GLU A OE2 1 
ATOM   1879 N  N   . GLN A 1 244 ? 1.33856   2.15281   65.35488 1.000 71.99294  ? 244 GLN A N   1 
ATOM   1880 C  CA  . GLN A 1 244 ? 2.76619   2.27193   65.08979 1.000 63.94561  ? 244 GLN A CA  1 
ATOM   1881 C  C   . GLN A 1 244 ? 3.54992   2.33046   66.40069 1.000 72.36558  ? 244 GLN A C   1 
ATOM   1882 O  O   . GLN A 1 244 ? 3.69881   1.32673   67.10024 1.000 73.46809  ? 244 GLN A O   1 
ATOM   1883 C  CB  . GLN A 1 244 ? 3.02836   3.52991   64.25063 1.000 55.50840  ? 244 GLN A CB  1 
ATOM   1884 C  CG  . GLN A 1 244 ? 4.49679   3.89137   64.02293 1.000 52.15998  ? 244 GLN A CG  1 
ATOM   1885 C  CD  . GLN A 1 244 ? 4.64645   5.23275   63.29816 1.000 47.11439  ? 244 GLN A CD  1 
ATOM   1886 O  OE1 . GLN A 1 244 ? 5.65294   5.48575   62.63634 1.000 37.42014  ? 244 GLN A OE1 1 
ATOM   1887 N  NE2 . GLN A 1 244 ? 3.63162   6.09459   63.42203 1.000 47.61103  ? 244 GLN A NE2 1 
ATOM   1888 N  N   . THR B 1 3   ? 45.29698  9.41249   31.93472 1.000 81.91881  ? 3   THR B N   1 
ATOM   1889 C  CA  . THR B 1 3   ? 45.47296  8.08591   31.34976 1.000 93.03264  ? 3   THR B CA  1 
ATOM   1890 C  C   . THR B 1 3   ? 45.91036  8.15305   29.87633 1.000 91.88882  ? 3   THR B C   1 
ATOM   1891 O  O   . THR B 1 3   ? 45.76473  9.19054   29.21808 1.000 81.31902  ? 3   THR B O   1 
ATOM   1892 C  CB  . THR B 1 3   ? 44.17824  7.24608   31.47396 1.000 87.73213  ? 3   THR B CB  1 
ATOM   1893 O  OG1 . THR B 1 3   ? 43.83029  6.67800   30.20075 1.000 76.82483  ? 3   THR B OG1 1 
ATOM   1894 C  CG2 . THR B 1 3   ? 43.04070  8.11294   31.98183 1.000 91.32282  ? 3   THR B CG2 1 
ATOM   1895 N  N   . GLU B 1 4   ? 46.44173  7.02580   29.38978 1.000 86.79023  ? 4   GLU B N   1 
ATOM   1896 C  CA  . GLU B 1 4   ? 47.09699  6.97150   28.08585 1.000 89.22005  ? 4   GLU B CA  1 
ATOM   1897 C  C   . GLU B 1 4   ? 46.22135  7.55782   26.98068 1.000 85.64633  ? 4   GLU B C   1 
ATOM   1898 O  O   . GLU B 1 4   ? 46.57512  8.56964   26.36125 1.000 81.44403  ? 4   GLU B O   1 
ATOM   1899 C  CB  . GLU B 1 4   ? 47.47628  5.52091   27.77013 1.000 88.14996  ? 4   GLU B CB  1 
ATOM   1900 C  CG  . GLU B 1 4   ? 48.12671  5.30308   26.39989 1.000 96.28587  ? 4   GLU B CG  1 
ATOM   1901 C  CD  . GLU B 1 4   ? 49.61202  5.65134   26.37557 1.000 103.71898 ? 4   GLU B CD  1 
ATOM   1902 O  OE1 . GLU B 1 4   ? 50.20405  5.82665   27.46630 1.000 102.67820 ? 4   GLU B OE1 1 
ATOM   1903 O  OE2 . GLU B 1 4   ? 50.18700  5.74725   25.26398 1.000 97.68758  ? 4   GLU B OE2 1 
ATOM   1904 N  N   . ALA B 1 5   ? 45.06824  6.93443   26.72203 1.000 79.23278  ? 5   ALA B N   1 
ATOM   1905 C  CA  . ALA B 1 5   ? 44.29503  7.28122   25.53256 1.000 67.80927  ? 5   ALA B CA  1 
ATOM   1906 C  C   . ALA B 1 5   ? 43.89443  8.74783   25.52464 1.000 66.68289  ? 5   ALA B C   1 
ATOM   1907 O  O   . ALA B 1 5   ? 43.87308  9.38047   24.46370 1.000 63.94366  ? 5   ALA B O   1 
ATOM   1908 C  CB  . ALA B 1 5   ? 43.05856  6.38661   25.42968 1.000 66.22478  ? 5   ALA B CB  1 
ATOM   1909 N  N   . ARG B 1 6   ? 43.59108  9.31177   26.69412 1.000 85.23490  ? 6   ARG B N   1 
ATOM   1910 C  CA  . ARG B 1 6   ? 43.22493  10.72339  26.75092 1.000 78.02911  ? 6   ARG B CA  1 
ATOM   1911 C  C   . ARG B 1 6   ? 44.42259  11.61980  26.44236 1.000 80.82229  ? 6   ARG B C   1 
ATOM   1912 O  O   . ARG B 1 6   ? 44.28508  12.61434  25.71960 1.000 78.13106  ? 6   ARG B O   1 
ATOM   1913 C  CB  . ARG B 1 6   ? 42.64188  11.05955  28.12310 1.000 85.78701  ? 6   ARG B CB  1 
ATOM   1914 C  CG  . ARG B 1 6   ? 41.53046  10.12553  28.59160 1.000 83.40660  ? 6   ARG B CG  1 
ATOM   1915 C  CD  . ARG B 1 6   ? 41.10629  10.44324  30.03200 1.000 84.97169  ? 6   ARG B CD  1 
ATOM   1916 N  NE  . ARG B 1 6   ? 40.17875  9.44776   30.55457 1.000 82.29884  ? 6   ARG B NE  1 
ATOM   1917 C  CZ  . ARG B 1 6   ? 39.84799  9.31725   31.83269 1.000 87.73392  ? 6   ARG B CZ  1 
ATOM   1918 N  NH1 . ARG B 1 6   ? 40.36382  10.10410  32.76553 1.000 92.22187  ? 6   ARG B NH1 1 
ATOM   1919 N  NH2 . ARG B 1 6   ? 38.98302  8.36721   32.18503 1.000 69.55529  ? 6   ARG B NH2 1 
ATOM   1920 N  N   . GLU B 1 7   ? 45.60612  11.28198  26.97912 1.000 88.42257  ? 7   GLU B N   1 
ATOM   1921 C  CA  . GLU B 1 7   ? 46.80681  12.07872  26.72481 1.000 86.92682  ? 7   GLU B CA  1 
ATOM   1922 C  C   . GLU B 1 7   ? 47.13476  12.14168  25.24867 1.000 88.05989  ? 7   GLU B C   1 
ATOM   1923 O  O   . GLU B 1 7   ? 47.47874  13.20895  24.72797 1.000 80.58921  ? 7   GLU B O   1 
ATOM   1924 C  CB  . GLU B 1 7   ? 47.99258  11.50844  27.49925 1.000 87.03074  ? 7   GLU B CB  1 
ATOM   1925 C  CG  . GLU B 1 7   ? 47.96331  11.67037  29.00785 1.000 96.17667  ? 7   GLU B CG  1 
ATOM   1926 C  CD  . GLU B 1 7   ? 48.61633  12.98148  29.47843 1.000 105.43875 ? 7   GLU B CD  1 
ATOM   1927 O  OE1 . GLU B 1 7   ? 49.15880  13.71197  28.63833 1.000 103.64399 ? 7   GLU B OE1 1 
ATOM   1928 O  OE2 . GLU B 1 7   ? 48.55428  13.25124  30.69191 1.000 107.95234 ? 7   GLU B OE2 1 
ATOM   1929 N  N   . GLU B 1 8   ? 47.02102  11.00907  24.56716 1.000 82.99885  ? 8   GLU B N   1 
ATOM   1930 C  CA  . GLU B 1 8   ? 47.50784  10.90351  23.20295 1.000 69.94458  ? 8   GLU B CA  1 
ATOM   1931 C  C   . GLU B 1 8   ? 46.67385  11.73017  22.23254 1.000 74.95115  ? 8   GLU B C   1 
ATOM   1932 O  O   . GLU B 1 8   ? 47.22708  12.40551  21.35655 1.000 76.99942  ? 8   GLU B O   1 
ATOM   1933 C  CB  . GLU B 1 8   ? 47.54666  9.43713   22.79129 1.000 71.09756  ? 8   GLU B CB  1 
ATOM   1934 C  CG  . GLU B 1 8   ? 48.53329  8.64509   23.61119 1.000 65.57877  ? 8   GLU B CG  1 
ATOM   1935 C  CD  . GLU B 1 8   ? 48.96943  7.37990   22.92428 1.000 74.83655  ? 8   GLU B CD  1 
ATOM   1936 O  OE1 . GLU B 1 8   ? 48.10533  6.51883   22.66319 1.000 76.39825  ? 8   GLU B OE1 1 
ATOM   1937 O  OE2 . GLU B 1 8   ? 50.17615  7.24851   22.63608 1.000 92.13781  ? 8   GLU B OE2 1 
ATOM   1938 N  N   . LEU B 1 9   ? 45.34737  11.70002  22.36888 1.000 80.77428  ? 9   LEU B N   1 
ATOM   1939 C  CA  . LEU B 1 9   ? 44.51318  12.53697  21.51280 1.000 75.69309  ? 9   LEU B CA  1 
ATOM   1940 C  C   . LEU B 1 9   ? 44.72319  14.01554  21.78486 1.000 75.42106  ? 9   LEU B C   1 
ATOM   1941 O  O   . LEU B 1 9   ? 44.45642  14.84084  20.90260 1.000 74.47170  ? 9   LEU B O   1 
ATOM   1942 C  CB  . LEU B 1 9   ? 43.02361  12.21039  21.68026 1.000 71.23070  ? 9   LEU B CB  1 
ATOM   1943 C  CG  . LEU B 1 9   ? 42.40893  11.13973  20.78641 1.000 56.91001  ? 9   LEU B CG  1 
ATOM   1944 C  CD1 . LEU B 1 9   ? 42.81875  9.77369   21.26991 1.000 53.10368  ? 9   LEU B CD1 1 
ATOM   1945 C  CD2 . LEU B 1 9   ? 40.88823  11.27184  20.76159 1.000 62.09814  ? 9   LEU B CD2 1 
ATOM   1946 N  N   . ARG B 1 10  ? 45.16521  14.37377  22.99074 1.000 78.85362  ? 10  ARG B N   1 
ATOM   1947 C  CA  . ARG B 1 10  ? 45.53445  15.76354  23.23368 1.000 80.29482  ? 10  ARG B CA  1 
ATOM   1948 C  C   . ARG B 1 10  ? 46.77902  16.14701  22.44098 1.000 87.13068  ? 10  ARG B C   1 
ATOM   1949 O  O   . ARG B 1 10  ? 46.82264  17.21682  21.81543 1.000 78.56545  ? 10  ARG B O   1 
ATOM   1950 C  CB  . ARG B 1 10  ? 45.74398  16.00108  24.72925 1.000 81.69092  ? 10  ARG B CB  1 
ATOM   1951 C  CG  . ARG B 1 10  ? 44.44440  16.01648  25.52832 1.000 90.55161  ? 10  ARG B CG  1 
ATOM   1952 C  CD  . ARG B 1 10  ? 44.62438  16.52459  26.94952 1.000 84.96277  ? 10  ARG B CD  1 
ATOM   1953 N  NE  . ARG B 1 10  ? 45.42119  15.61786  27.77451 1.000 95.02566  ? 10  ARG B NE  1 
ATOM   1954 C  CZ  . ARG B 1 10  ? 44.91997  14.77388  28.67115 1.000 103.04323 ? 10  ARG B CZ  1 
ATOM   1955 N  NH1 . ARG B 1 10  ? 43.61461  14.67130  28.87308 1.000 106.24967 ? 10  ARG B NH1 1 
ATOM   1956 N  NH2 . ARG B 1 10  ? 45.74826  14.01677  29.38963 1.000 100.39797 ? 10  ARG B NH2 1 
ATOM   1957 N  N   . ALA B 1 11  ? 47.78655  15.27213  22.43324 1.000 82.65804  ? 11  ALA B N   1 
ATOM   1958 C  CA  . ALA B 1 11  ? 49.03371  15.55703  21.73373 1.000 84.40261  ? 11  ALA B CA  1 
ATOM   1959 C  C   . ALA B 1 11  ? 48.90975  15.32064  20.23177 1.000 80.35264  ? 11  ALA B C   1 
ATOM   1960 O  O   . ALA B 1 11  ? 49.08833  16.24354  19.43093 1.000 84.83282  ? 11  ALA B O   1 
ATOM   1961 C  CB  . ALA B 1 11  ? 50.16402  14.70725  22.32081 1.000 76.58717  ? 11  ALA B CB  1 
ATOM   1962 N  N   . ASN B 1 12  ? 48.58269  14.09303  19.83437 1.000 71.66159  ? 12  ASN B N   1 
ATOM   1963 C  CA  . ASN B 1 12  ? 48.70112  13.67752  18.44229 1.000 79.04253  ? 12  ASN B CA  1 
ATOM   1964 C  C   . ASN B 1 12  ? 47.41132  13.78164  17.63930 1.000 79.79961  ? 12  ASN B C   1 
ATOM   1965 O  O   . ASN B 1 12  ? 47.48065  13.86978  16.40986 1.000 79.87846  ? 12  ASN B O   1 
ATOM   1966 C  CB  . ASN B 1 12  ? 49.20414  12.23006  18.36303 1.000 74.27612  ? 12  ASN B CB  1 
ATOM   1967 C  CG  . ASN B 1 12  ? 50.50753  12.03132  19.09869 1.000 81.26427  ? 12  ASN B CG  1 
ATOM   1968 O  OD1 . ASN B 1 12  ? 50.96030  12.91634  19.82692 1.000 89.33827  ? 12  ASN B OD1 1 
ATOM   1969 N  ND2 . ASN B 1 12  ? 51.11505  10.86490  18.92584 1.000 82.07124  ? 12  ASN B ND2 1 
ATOM   1970 N  N   . GLY B 1 13  ? 46.24885  13.76100  18.28000 1.000 72.98913  ? 13  GLY B N   1 
ATOM   1971 C  CA  . GLY B 1 13  ? 44.99786  13.72121  17.55232 1.000 63.59985  ? 13  GLY B CA  1 
ATOM   1972 C  C   . GLY B 1 13  ? 44.48234  12.33228  17.24917 1.000 54.49630  ? 13  GLY B C   1 
ATOM   1973 O  O   . GLY B 1 13  ? 43.50772  12.19639  16.49559 1.000 50.06631  ? 13  GLY B O   1 
ATOM   1974 N  N   . TYR B 1 14  ? 45.09911  11.29843  17.81061 1.000 51.53846  ? 14  TYR B N   1 
ATOM   1975 C  CA  . TYR B 1 14  ? 44.66788  9.93269   17.55958 1.000 56.83289  ? 14  TYR B CA  1 
ATOM   1976 C  C   . TYR B 1 14  ? 45.40024  8.99549   18.51173 1.000 58.03735  ? 14  TYR B C   1 
ATOM   1977 O  O   . TYR B 1 14  ? 46.52759  9.27231   18.93031 1.000 62.53009  ? 14  TYR B O   1 
ATOM   1978 C  CB  . TYR B 1 14  ? 44.90824  9.51099   16.09926 1.000 59.08795  ? 14  TYR B CB  1 
ATOM   1979 C  CG  . TYR B 1 14  ? 46.27672  8.93825   15.84898 1.000 63.94258  ? 14  TYR B CG  1 
ATOM   1980 C  CD1 . TYR B 1 14  ? 47.38115  9.77564   15.69350 1.000 69.71990  ? 14  TYR B CD1 1 
ATOM   1981 C  CD2 . TYR B 1 14  ? 46.47266  7.55776   15.77288 1.000 61.60511  ? 14  TYR B CD2 1 
ATOM   1982 C  CE1 . TYR B 1 14  ? 48.64379  9.25641   15.47067 1.000 72.24060  ? 14  TYR B CE1 1 
ATOM   1983 C  CE2 . TYR B 1 14  ? 47.72603  7.02843   15.55475 1.000 66.03527  ? 14  TYR B CE2 1 
ATOM   1984 C  CZ  . TYR B 1 14  ? 48.80959  7.88310   15.40266 1.000 76.35319  ? 14  TYR B CZ  1 
ATOM   1985 O  OH  . TYR B 1 14  ? 50.06427  7.36241   15.17897 1.000 76.57377  ? 14  TYR B OH  1 
ATOM   1986 N  N   . SER B 1 15  ? 44.74973  7.88116   18.83923 1.000 47.83126  ? 15  SER B N   1 
ATOM   1987 C  CA  . SER B 1 15  ? 45.34037  6.88207   19.71260 1.000 53.22329  ? 15  SER B CA  1 
ATOM   1988 C  C   . SER B 1 15  ? 44.91858  5.51306   19.22222 1.000 56.22935  ? 15  SER B C   1 
ATOM   1989 O  O   . SER B 1 15  ? 43.82121  5.34893   18.69063 1.000 68.04674  ? 15  SER B O   1 
ATOM   1990 C  CB  . SER B 1 15  ? 44.91390  7.06855   21.17782 1.000 63.09431  ? 15  SER B CB  1 
ATOM   1991 O  OG  . SER B 1 15  ? 45.12953  5.89235   21.94793 1.000 59.84258  ? 15  SER B OG  1 
ATOM   1992 N  N   . LEU B 1 16  ? 45.78796  4.53828   19.40856 1.000 52.53903  ? 16  LEU B N   1 
ATOM   1993 C  CA  . LEU B 1 16  ? 45.52374  3.17597   18.99589 1.000 56.78794  ? 16  LEU B CA  1 
ATOM   1994 C  C   . LEU B 1 16  ? 45.28355  2.32127   20.22671 1.000 62.86398  ? 16  LEU B C   1 
ATOM   1995 O  O   . LEU B 1 16  ? 45.80016  2.59968   21.31429 1.000 63.63460  ? 16  LEU B O   1 
ATOM   1996 C  CB  . LEU B 1 16  ? 46.68984  2.60832   18.17762 1.000 61.98625  ? 16  LEU B CB  1 
ATOM   1997 C  CG  . LEU B 1 16  ? 46.78450  3.11005   16.74077 1.000 64.26737  ? 16  LEU B CG  1 
ATOM   1998 C  CD1 . LEU B 1 16  ? 47.95150  2.44788   16.02672 1.000 59.19494  ? 16  LEU B CD1 1 
ATOM   1999 C  CD2 . LEU B 1 16  ? 45.47933  2.80812   16.03181 1.000 65.94141  ? 16  LEU B CD2 1 
ATOM   2000 N  N   . LEU B 1 17  ? 44.48314  1.28163   20.04918 1.000 57.46723  ? 17  LEU B N   1 
ATOM   2001 C  CA  . LEU B 1 17  ? 44.14726  0.36673   21.13787 1.000 63.29818  ? 17  LEU B CA  1 
ATOM   2002 C  C   . LEU B 1 17  ? 43.89998  -0.99161  20.54713 1.000 65.24324  ? 17  LEU B C   1 
ATOM   2003 O  O   . LEU B 1 17  ? 42.74046  -1.40419  20.33489 1.000 65.91143  ? 17  LEU B O   1 
ATOM   2004 C  CB  . LEU B 1 17  ? 42.94033  0.86532   21.92571 1.000 62.72573  ? 17  LEU B CB  1 
ATOM   2005 C  CG  . LEU B 1 17  ? 42.62643  0.06737   23.19159 1.000 66.42406  ? 17  LEU B CG  1 
ATOM   2006 C  CD1 . LEU B 1 17  ? 43.76957  0.16805   24.16973 1.000 54.90951  ? 17  LEU B CD1 1 
ATOM   2007 C  CD2 . LEU B 1 17  ? 41.32816  0.54554   23.82568 1.000 65.59887  ? 17  LEU B CD2 1 
ATOM   2008 N  N   . PRO B 1 18  ? 44.94599  -1.75101  20.23252 1.000 75.32262  ? 18  PRO B N   1 
ATOM   2009 C  CA  . PRO B 1 18  ? 44.76384  -3.06784  19.63496 1.000 72.78629  ? 18  PRO B CA  1 
ATOM   2010 C  C   . PRO B 1 18  ? 44.08958  -4.02709  20.60841 1.000 72.30871  ? 18  PRO B C   1 
ATOM   2011 O  O   . PRO B 1 18  ? 44.17329  -3.87562  21.83156 1.000 74.98444  ? 18  PRO B O   1 
ATOM   2012 C  CB  . PRO B 1 18  ? 46.18616  -3.52008  19.28915 1.000 69.99362  ? 18  PRO B CB  1 
ATOM   2013 C  CG  . PRO B 1 18  ? 47.06692  -2.68495  20.13414 1.000 73.22574  ? 18  PRO B CG  1 
ATOM   2014 C  CD  . PRO B 1 18  ? 46.37656  -1.37313  20.31069 1.000 66.78210  ? 18  PRO B CD  1 
ATOM   2015 N  N   . ALA B 1 19  ? 43.40436  -5.01682  20.03760 1.000 67.20755  ? 19  ALA B N   1 
ATOM   2016 C  CA  . ALA B 1 19  ? 42.70504  -6.00839  20.84065 1.000 60.85302  ? 19  ALA B CA  1 
ATOM   2017 C  C   . ALA B 1 19  ? 43.64485  -6.76254  21.76657 1.000 80.17278  ? 19  ALA B C   1 
ATOM   2018 O  O   . ALA B 1 19  ? 43.22950  -7.19356  22.85055 1.000 82.81271  ? 19  ALA B O   1 
ATOM   2019 C  CB  . ALA B 1 19  ? 41.98893  -6.99100  19.93051 1.000 56.60129  ? 19  ALA B CB  1 
ATOM   2020 N  N   . ASP B 1 20  ? 44.89985  -6.95468  21.34664 1.000 78.86493  ? 20  ASP B N   1 
ATOM   2021 C  CA  . ASP B 1 20  ? 45.89488  -7.59492  22.20135 1.000 81.93069  ? 20  ASP B CA  1 
ATOM   2022 C  C   . ASP B 1 20  ? 45.89764  -6.99122  23.60140 1.000 90.11784  ? 20  ASP B C   1 
ATOM   2023 O  O   . ASP B 1 20  ? 45.92971  -7.71892  24.60217 1.000 89.65089  ? 20  ASP B O   1 
ATOM   2024 C  CB  . ASP B 1 20  ? 47.27926  -7.47108  21.56087 1.000 79.47983  ? 20  ASP B CB  1 
ATOM   2025 C  CG  . ASP B 1 20  ? 48.38546  -8.04353  22.43343 1.000 93.17599  ? 20  ASP B CG  1 
ATOM   2026 O  OD1 . ASP B 1 20  ? 48.09565  -8.91609  23.28247 1.000 101.77088 ? 20  ASP B OD1 1 
ATOM   2027 O  OD2 . ASP B 1 20  ? 49.55281  -7.61648  22.27500 1.000 97.15107  ? 20  ASP B OD2 1 
ATOM   2028 N  N   . ARG B 1 21  ? 45.84427  -5.66228  23.69023 1.000 89.64594  ? 21  ARG B N   1 
ATOM   2029 C  CA  . ARG B 1 21  ? 45.86181  -4.95917  24.96598 1.000 89.26553  ? 21  ARG B CA  1 
ATOM   2030 C  C   . ARG B 1 21  ? 44.48742  -4.86773  25.62314 1.000 90.21454  ? 21  ARG B C   1 
ATOM   2031 O  O   . ARG B 1 21  ? 44.32348  -4.10636  26.58291 1.000 88.83015  ? 21  ARG B O   1 
ATOM   2032 C  CB  . ARG B 1 21  ? 46.44799  -3.55799  24.77816 1.000 90.36244  ? 21  ARG B CB  1 
ATOM   2033 C  CG  . ARG B 1 21  ? 47.92689  -3.56544  24.43024 1.000 93.92253  ? 21  ARG B CG  1 
ATOM   2034 C  CD  . ARG B 1 21  ? 48.49776  -2.15758  24.33812 1.000 97.64860  ? 21  ARG B CD  1 
ATOM   2035 N  NE  . ARG B 1 21  ? 49.94863  -2.16981  24.17518 1.000 101.28598 ? 21  ARG B NE  1 
ATOM   2036 C  CZ  . ARG B 1 21  ? 50.71048  -1.08389  24.14593 1.000 107.45027 ? 21  ARG B CZ  1 
ATOM   2037 N  NH1 . ARG B 1 21  ? 50.19053  0.12854   24.24871 1.000 108.38172 ? 21  ARG B NH1 1 
ATOM   2038 N  NH2 . ARG B 1 21  ? 52.02786  -1.21728  24.01267 1.000 112.00588 ? 21  ARG B NH2 1 
ATOM   2039 N  N   . LEU B 1 22  ? 43.50487  -5.61822  25.14067 1.000 89.90906  ? 22  LEU B N   1 
ATOM   2040 C  CA  . LEU B 1 22  ? 42.19472  -5.69432  25.76583 1.000 84.73293  ? 22  LEU B CA  1 
ATOM   2041 C  C   . LEU B 1 22  ? 42.03486  -7.06498  26.40887 1.000 88.26679  ? 22  LEU B C   1 
ATOM   2042 O  O   . LEU B 1 22  ? 42.57114  -8.06434  25.91794 1.000 82.16960  ? 22  LEU B O   1 
ATOM   2043 C  CB  . LEU B 1 22  ? 41.08285  -5.43522  24.73565 1.000 81.75264  ? 22  LEU B CB  1 
ATOM   2044 C  CG  . LEU B 1 22  ? 39.59938  -5.60844  25.07376 1.000 90.71594  ? 22  LEU B CG  1 
ATOM   2045 C  CD1 . LEU B 1 22  ? 38.76866  -4.58599  24.30891 1.000 80.19838  ? 22  LEU B CD1 1 
ATOM   2046 C  CD2 . LEU B 1 22  ? 39.11403  -7.03147  24.76080 1.000 84.55172  ? 22  LEU B CD2 1 
ATOM   2047 N  N   . VAL B 1 23  ? 41.31237  -7.09926  27.52450 1.000 92.80837  ? 23  VAL B N   1 
ATOM   2048 C  CA  . VAL B 1 23  ? 41.01918  -8.33583  28.24061 1.000 86.76045  ? 23  VAL B CA  1 
ATOM   2049 C  C   . VAL B 1 23  ? 39.64575  -8.82236  27.78720 1.000 88.85250  ? 23  VAL B C   1 
ATOM   2050 O  O   . VAL B 1 23  ? 38.62620  -8.18486  28.06464 1.000 91.95359  ? 23  VAL B O   1 
ATOM   2051 C  CB  . VAL B 1 23  ? 41.08468  -8.12970  29.75939 1.000 87.45645  ? 23  VAL B CB  1 
ATOM   2052 C  CG1 . VAL B 1 23  ? 42.52687  -7.96893  30.19487 1.000 90.49096  ? 23  VAL B CG1 1 
ATOM   2053 C  CG2 . VAL B 1 23  ? 40.28508  -6.90005  30.18068 1.000 92.59899  ? 23  VAL B CG2 1 
ATOM   2054 N  N   . ILE B 1 24  ? 39.60315  -9.94485  27.07361 1.000 87.93491  ? 24  ILE B N   1 
ATOM   2055 C  CA  . ILE B 1 24  ? 38.36513  -10.44018 26.47991 1.000 90.55965  ? 24  ILE B CA  1 
ATOM   2056 C  C   . ILE B 1 24  ? 37.93047  -11.71601 27.19205 1.000 98.38135  ? 24  ILE B C   1 
ATOM   2057 O  O   . ILE B 1 24  ? 38.46723  -12.79746 26.92609 1.000 102.81996 ? 24  ILE B O   1 
ATOM   2058 C  CB  . ILE B 1 24  ? 38.53754  -10.67293 24.98230 1.000 82.79168  ? 24  ILE B CB  1 
ATOM   2059 N  N   . ASP B 1 25  ? 36.94782  -11.58697 28.08381 1.000 98.65584  ? 25  ASP B N   1 
ATOM   2060 C  CA  . ASP B 1 25  ? 36.38726  -12.72967 28.78695 1.000 98.23670  ? 25  ASP B CA  1 
ATOM   2061 C  C   . ASP B 1 25  ? 35.45335  -13.51072 27.86580 1.000 102.73056 ? 25  ASP B C   1 
ATOM   2062 O  O   . ASP B 1 25  ? 35.19885  -13.12355 26.72087 1.000 98.47271  ? 25  ASP B O   1 
ATOM   2063 C  CB  . ASP B 1 25  ? 35.64359  -12.27416 30.03691 1.000 93.22846  ? 25  ASP B CB  1 
ATOM   2064 C  CG  . ASP B 1 25  ? 34.57244  -11.26226 29.72734 1.000 92.74120  ? 25  ASP B CG  1 
ATOM   2065 O  OD1 . ASP B 1 25  ? 34.92988  -10.11795 29.37688 1.000 87.36522  ? 25  ASP B OD1 1 
ATOM   2066 O  OD2 . ASP B 1 25  ? 33.37892  -11.61701 29.80960 1.000 87.01300  ? 25  ASP B OD2 1 
ATOM   2067 N  N   . ALA B 1 26  ? 34.92172  -14.62279 28.38919 1.000 104.81044 ? 26  ALA B N   1 
ATOM   2068 C  CA  . ALA B 1 26  ? 34.04534  -15.48326 27.59900 1.000 99.42962  ? 26  ALA B CA  1 
ATOM   2069 C  C   . ALA B 1 26  ? 32.75086  -14.77495 27.22788 1.000 99.04110  ? 26  ALA B C   1 
ATOM   2070 O  O   . ALA B 1 26  ? 32.24581  -14.94141 26.10989 1.000 99.78753  ? 26  ALA B O   1 
ATOM   2071 C  CB  . ALA B 1 26  ? 33.73605  -16.75968 28.36950 1.000 101.35235 ? 26  ALA B CB  1 
ATOM   2072 N  N   . GLU B 1 27  ? 32.18503  -14.00591 28.16401 1.000 97.41605  ? 27  GLU B N   1 
ATOM   2073 C  CA  . GLU B 1 27  ? 30.96893  -13.24909 27.88034 1.000 94.07705  ? 27  GLU B CA  1 
ATOM   2074 C  C   . GLU B 1 27  ? 31.22219  -12.20705 26.80013 1.000 94.35941  ? 27  GLU B C   1 
ATOM   2075 O  O   . GLU B 1 27  ? 30.59778  -12.23150 25.73049 1.000 92.75989  ? 27  GLU B O   1 
ATOM   2076 C  CB  . GLU B 1 27  ? 30.45082  -12.57188 29.15071 1.000 97.06546  ? 27  GLU B CB  1 
ATOM   2077 C  CG  . GLU B 1 27  ? 29.28063  -11.61651 28.90149 1.000 90.96731  ? 27  GLU B CG  1 
ATOM   2078 C  CD  . GLU B 1 27  ? 29.10240  -10.60333 30.01203 1.000 73.10468  ? 27  GLU B CD  1 
ATOM   2079 O  OE1 . GLU B 1 27  ? 29.76677  -10.77022 31.05864 1.000 79.88491  ? 27  GLU B OE1 1 
ATOM   2080 O  OE2 . GLU B 1 27  ? 28.31922  -9.64357  29.84309 1.000 58.75997  ? 27  GLU B OE2 1 
ATOM   2081 N  N   . LEU B 1 28  ? 32.13813  -11.27093 27.07246 1.000 91.57077  ? 28  LEU B N   1 
ATOM   2082 C  CA  . LEU B 1 28  ? 32.51820  -10.29531 26.05904 1.000 84.85160  ? 28  LEU B CA  1 
ATOM   2083 C  C   . LEU B 1 28  ? 32.86549  -10.97596 24.74354 1.000 84.15257  ? 28  LEU B C   1 
ATOM   2084 O  O   . LEU B 1 28  ? 32.44194  -10.51845 23.67640 1.000 80.30202  ? 28  LEU B O   1 
ATOM   2085 C  CB  . LEU B 1 28  ? 33.69076  -9.45370  26.54798 1.000 84.90763  ? 28  LEU B CB  1 
ATOM   2086 C  CG  . LEU B 1 28  ? 34.07272  -8.36652  25.54103 1.000 82.77628  ? 28  LEU B CG  1 
ATOM   2087 C  CD1 . LEU B 1 28  ? 32.84873  -7.56109  25.17935 1.000 71.17462  ? 28  LEU B CD1 1 
ATOM   2088 C  CD2 . LEU B 1 28  ? 35.15288  -7.45955  26.08653 1.000 80.67830  ? 28  LEU B CD2 1 
ATOM   2089 N  N   . ARG B 1 29  ? 33.61948  -12.08161 24.80749 1.000 82.98231  ? 29  ARG B N   1 
ATOM   2090 C  CA  . ARG B 1 29  ? 33.88241  -12.90191 23.62653 1.000 83.04395  ? 29  ARG B CA  1 
ATOM   2091 C  C   . ARG B 1 29  ? 32.59830  -13.16494 22.84561 1.000 81.72015  ? 29  ARG B C   1 
ATOM   2092 O  O   . ARG B 1 29  ? 32.52146  -12.88919 21.64264 1.000 82.08329  ? 29  ARG B O   1 
ATOM   2093 C  CB  . ARG B 1 29  ? 34.54293  -14.22382 24.05029 1.000 96.99062  ? 29  ARG B CB  1 
ATOM   2094 C  CG  . ARG B 1 29  ? 34.93339  -15.18989 22.92882 1.000 98.37848  ? 29  ARG B CG  1 
ATOM   2095 C  CD  . ARG B 1 29  ? 35.29710  -16.57885 23.49663 1.000 100.09139 ? 29  ARG B CD  1 
ATOM   2096 N  NE  . ARG B 1 29  ? 36.49305  -16.56607 24.33657 1.000 104.90313 ? 29  ARG B NE  1 
ATOM   2097 C  CZ  . ARG B 1 29  ? 36.85504  -17.55395 25.14691 1.000 101.24672 ? 29  ARG B CZ  1 
ATOM   2098 N  NH1 . ARG B 1 29  ? 36.10767  -18.63406 25.29578 1.000 92.47398  ? 29  ARG B NH1 1 
ATOM   2099 N  NH2 . ARG B 1 29  ? 37.99597  -17.45497 25.82666 1.000 102.78089 ? 29  ARG B NH2 1 
ATOM   2100 N  N   . GLN B 1 30  ? 31.56356  -13.67041 23.52841 1.000 77.99536  ? 30  GLN B N   1 
ATOM   2101 C  CA  . GLN B 1 30  ? 30.34138  -14.05659 22.83282 1.000 81.31893  ? 30  GLN B CA  1 
ATOM   2102 C  C   . GLN B 1 30  ? 29.50231  -12.84407 22.45125 1.000 75.58074  ? 30  GLN B C   1 
ATOM   2103 O  O   . GLN B 1 30  ? 28.73588  -12.91076 21.48406 1.000 76.82000  ? 30  GLN B O   1 
ATOM   2104 C  CB  . GLN B 1 30  ? 29.52906  -15.03327 23.69188 1.000 88.59215  ? 30  GLN B CB  1 
ATOM   2105 C  CG  . GLN B 1 30  ? 28.35073  -15.71424 22.96549 1.000 97.55993  ? 30  GLN B CG  1 
ATOM   2106 C  CD  . GLN B 1 30  ? 28.78494  -16.73086 21.91125 1.000 99.64599  ? 30  GLN B CD  1 
ATOM   2107 O  OE1 . GLN B 1 30  ? 29.73484  -17.49488 22.11439 1.000 95.65379  ? 30  GLN B OE1 1 
ATOM   2108 N  NE2 . GLN B 1 30  ? 28.08306  -16.74466 20.78012 1.000 96.55867  ? 30  GLN B NE2 1 
ATOM   2109 N  N   . HIS B 1 31  ? 29.61626  -11.73585 23.19292 1.000 71.40647  ? 31  HIS B N   1 
ATOM   2110 C  CA  . HIS B 1 31  ? 28.91016  -10.52564 22.77803 1.000 69.61824  ? 31  HIS B CA  1 
ATOM   2111 C  C   . HIS B 1 31  ? 29.56393  -9.88591  21.55704 1.000 68.97748  ? 31  HIS B C   1 
ATOM   2112 O  O   . HIS B 1 31  ? 28.87089  -9.27025  20.73709 1.000 61.45700  ? 31  HIS B O   1 
ATOM   2113 C  CB  . HIS B 1 31  ? 28.83400  -9.52089  23.92666 1.000 66.39910  ? 31  HIS B CB  1 
ATOM   2114 C  CG  . HIS B 1 31  ? 27.70211  -9.77016  24.88142 1.000 77.16536  ? 31  HIS B CG  1 
ATOM   2115 N  ND1 . HIS B 1 31  ? 26.52785  -10.39041 24.50598 1.000 74.90622  ? 31  HIS B ND1 1 
ATOM   2116 C  CD2 . HIS B 1 31  ? 27.56818  -9.47935  26.19865 1.000 64.18000  ? 31  HIS B CD2 1 
ATOM   2117 C  CE1 . HIS B 1 31  ? 25.72227  -10.47115 25.55031 1.000 66.29681  ? 31  HIS B CE1 1 
ATOM   2118 N  NE2 . HIS B 1 31  ? 26.33135  -9.92754  26.58868 1.000 58.97603  ? 31  HIS B NE2 1 
ATOM   2119 N  N   . VAL B 1 32  ? 30.88520  -10.02947 21.41272 1.000 67.03972  ? 32  VAL B N   1 
ATOM   2120 C  CA  . VAL B 1 32  ? 31.54104  -9.61073  20.18074 1.000 62.73828  ? 32  VAL B CA  1 
ATOM   2121 C  C   . VAL B 1 32  ? 31.17089  -10.54820 19.04065 1.000 65.11535  ? 32  VAL B C   1 
ATOM   2122 O  O   . VAL B 1 32  ? 30.91737  -10.10341 17.91387 1.000 62.41011  ? 32  VAL B O   1 
ATOM   2123 C  CB  . VAL B 1 32  ? 33.06686  -9.53527  20.37312 1.000 66.74619  ? 32  VAL B CB  1 
ATOM   2124 C  CG1 . VAL B 1 32  ? 33.72615  -9.04328  19.10578 1.000 60.25561  ? 32  VAL B CG1 1 
ATOM   2125 C  CG2 . VAL B 1 32  ? 33.41696  -8.60641  21.51647 1.000 62.06096  ? 32  VAL B CG2 1 
ATOM   2126 N  N   . LYS B 1 33  ? 31.13152  -11.85798 19.31018 1.000 62.24522  ? 33  LYS B N   1 
ATOM   2127 C  CA  . LYS B 1 33  ? 30.78936  -12.81503 18.26066 1.000 75.25307  ? 33  LYS B CA  1 
ATOM   2128 C  C   . LYS B 1 33  ? 29.41987  -12.50785 17.66751 1.000 68.69810  ? 33  LYS B C   1 
ATOM   2129 O  O   . LYS B 1 33  ? 29.23995  -12.53770 16.44123 1.000 64.85724  ? 33  LYS B O   1 
ATOM   2130 C  CB  . LYS B 1 33  ? 30.82412  -14.24218 18.81286 1.000 74.72638  ? 33  LYS B CB  1 
ATOM   2131 C  CG  . LYS B 1 33  ? 32.20284  -14.71167 19.23857 1.000 76.47817  ? 33  LYS B CG  1 
ATOM   2132 C  CD  . LYS B 1 33  ? 33.23036  -14.50315 18.13005 1.000 85.28174  ? 33  LYS B CD  1 
ATOM   2133 C  CE  . LYS B 1 33  ? 34.62621  -14.90523 18.58741 1.000 91.88635  ? 33  LYS B CE  1 
ATOM   2134 N  NZ  . LYS B 1 33  ? 35.04581  -14.11897 19.77966 1.000 94.20052  ? 33  LYS B NZ  1 
ATOM   2135 N  N   . GLU B 1 34  ? 28.45277  -12.17743 18.53039 1.000 62.16576  ? 34  GLU B N   1 
ATOM   2136 C  CA  . GLU B 1 34  ? 27.09303  -11.86468 18.10728 1.000 66.42628  ? 34  GLU B CA  1 
ATOM   2137 C  C   . GLU B 1 34  ? 27.00852  -10.49943 17.43734 1.000 59.89680  ? 34  GLU B C   1 
ATOM   2138 O  O   . GLU B 1 34  ? 26.33768  -10.34863 16.41120 1.000 64.84538  ? 34  GLU B O   1 
ATOM   2139 C  CB  . GLU B 1 34  ? 26.16353  -11.92992 19.31732 1.000 65.26062  ? 34  GLU B CB  1 
ATOM   2140 C  CG  . GLU B 1 34  ? 26.10258  -13.31768 19.95033 1.000 78.18053  ? 34  GLU B CG  1 
ATOM   2141 C  CD  . GLU B 1 34  ? 25.40434  -13.33580 21.30123 1.000 86.28776  ? 34  GLU B CD  1 
ATOM   2142 O  OE1 . GLU B 1 34  ? 25.44273  -12.31053 22.01880 1.000 77.01088  ? 34  GLU B OE1 1 
ATOM   2143 O  OE2 . GLU B 1 34  ? 24.81215  -14.38371 21.64560 1.000 86.07767  ? 34  GLU B OE2 1 
ATOM   2144 N  N   . LEU B 1 35  ? 27.66479  -9.49181  18.01314 1.000 54.42263  ? 35  LEU B N   1 
ATOM   2145 C  CA  . LEU B 1 35  ? 27.67057  -8.16994  17.39868 1.000 57.30122  ? 35  LEU B CA  1 
ATOM   2146 C  C   . LEU B 1 35  ? 28.34288  -8.19596  16.03151 1.000 68.02170  ? 35  LEU B C   1 
ATOM   2147 O  O   . LEU B 1 35  ? 27.88410  -7.53141  15.09406 1.000 63.89435  ? 35  LEU B O   1 
ATOM   2148 C  CB  . LEU B 1 35  ? 28.37585  -7.17929  18.31661 1.000 50.11235  ? 35  LEU B CB  1 
ATOM   2149 C  CG  . LEU B 1 35  ? 28.49081  -5.76351  17.77291 1.000 44.74344  ? 35  LEU B CG  1 
ATOM   2150 C  CD1 . LEU B 1 35  ? 27.10459  -5.18818  17.49049 1.000 46.91825  ? 35  LEU B CD1 1 
ATOM   2151 C  CD2 . LEU B 1 35  ? 29.24025  -4.91400  18.76036 1.000 41.77456  ? 35  LEU B CD2 1 
ATOM   2152 N  N   . ALA B 1 36  ? 29.43078  -8.96503  15.90041 1.000 59.69369  ? 36  ALA B N   1 
ATOM   2153 C  CA  . ALA B 1 36  ? 30.16336  -9.01704  14.64124 1.000 59.24129  ? 36  ALA B CA  1 
ATOM   2154 C  C   . ALA B 1 36  ? 29.42185  -9.81578  13.58395 1.000 62.04501  ? 36  ALA B C   1 
ATOM   2155 O  O   . ALA B 1 36  ? 29.60656  -9.56806  12.38701 1.000 67.28488  ? 36  ALA B O   1 
ATOM   2156 C  CB  . ALA B 1 36  ? 31.54833  -9.61281  14.86400 1.000 50.13256  ? 36  ALA B CB  1 
ATOM   2157 N  N   . ALA B 1 37  ? 28.60153  -10.78336 13.99893 1.000 55.77095  ? 37  ALA B N   1 
ATOM   2158 C  CA  . ALA B 1 37  ? 27.81340  -11.55143 13.04713 1.000 57.16797  ? 37  ALA B CA  1 
ATOM   2159 C  C   . ALA B 1 37  ? 26.80178  -10.69078 12.29950 1.000 68.01752  ? 37  ALA B C   1 
ATOM   2160 O  O   . ALA B 1 37  ? 26.37572  -11.06814 11.20327 1.000 68.27050  ? 37  ALA B O   1 
ATOM   2161 C  CB  . ALA B 1 37  ? 27.10015  -12.68957 13.76565 1.000 59.81008  ? 37  ALA B CB  1 
ATOM   2162 N  N   . GLU B 1 38  ? 26.41751  -9.54276  12.86150 1.000 69.59160  ? 38  GLU B N   1 
ATOM   2163 C  CA  . GLU B 1 38  ? 25.46282  -8.65577  12.20481 1.000 65.82126  ? 38  GLU B CA  1 
ATOM   2164 C  C   . GLU B 1 38  ? 25.95317  -8.12660  10.86621 1.000 68.15723  ? 38  GLU B C   1 
ATOM   2165 O  O   . GLU B 1 38  ? 25.12895  -7.73834  10.03025 1.000 68.99933  ? 38  GLU B O   1 
ATOM   2166 C  CB  . GLU B 1 38  ? 25.14727  -7.47984  13.11819 1.000 60.58869  ? 38  GLU B CB  1 
ATOM   2167 C  CG  . GLU B 1 38  ? 24.55020  -7.91856  14.41910 1.000 65.63454  ? 38  GLU B CG  1 
ATOM   2168 C  CD  . GLU B 1 38  ? 23.16095  -8.48557  14.22837 1.000 74.74832  ? 38  GLU B CD  1 
ATOM   2169 O  OE1 . GLU B 1 38  ? 22.44279  -8.03763  13.30276 1.000 76.71091  ? 38  GLU B OE1 1 
ATOM   2170 O  OE2 . GLU B 1 38  ? 22.78149  -9.38643  15.00145 1.000 78.36562  ? 38  GLU B OE2 1 
ATOM   2171 N  N   . TRP B 1 39  ? 27.26786  -8.07286  10.65090 1.000 64.11734  ? 39  TRP B N   1 
ATOM   2172 C  CA  . TRP B 1 39  ? 27.79199  -7.47243  9.43458  1.000 68.91320  ? 39  TRP B CA  1 
ATOM   2173 C  C   . TRP B 1 39  ? 27.45849  -8.28447  8.18682  1.000 75.64689  ? 39  TRP B C   1 
ATOM   2174 O  O   . TRP B 1 39  ? 27.54545  -7.75254  7.07183  1.000 78.68160  ? 39  TRP B O   1 
ATOM   2175 C  CB  . TRP B 1 39  ? 29.29913  -7.27214  9.58755  1.000 57.75967  ? 39  TRP B CB  1 
ATOM   2176 C  CG  . TRP B 1 39  ? 29.67043  -5.90017  10.08821 1.000 56.21504  ? 39  TRP B CG  1 
ATOM   2177 C  CD1 . TRP B 1 39  ? 30.27899  -4.90456  9.37537  1.000 57.80535  ? 39  TRP B CD1 1 
ATOM   2178 C  CD2 . TRP B 1 39  ? 29.44859  -5.37178  11.40027 1.000 52.56623  ? 39  TRP B CD2 1 
ATOM   2179 N  NE1 . TRP B 1 39  ? 30.45904  -3.79701  10.16485 1.000 53.42563  ? 39  TRP B NE1 1 
ATOM   2180 C  CE2 . TRP B 1 39  ? 29.96141  -4.05863  11.41468 1.000 54.44902  ? 39  TRP B CE2 1 
ATOM   2181 C  CE3 . TRP B 1 39  ? 28.87675  -5.88453  12.56999 1.000 55.28972  ? 39  TRP B CE3 1 
ATOM   2182 C  CZ2 . TRP B 1 39  ? 29.90638  -3.24419  12.55356 1.000 58.87696  ? 39  TRP B CZ2 1 
ATOM   2183 C  CZ3 . TRP B 1 39  ? 28.82269  -5.07032  13.70397 1.000 50.08947  ? 39  TRP B CZ3 1 
ATOM   2184 C  CH2 . TRP B 1 39  ? 29.33050  -3.76910  13.68446 1.000 47.74628  ? 39  TRP B CH2 1 
ATOM   2185 N  N   . GLU B 1 40  ? 27.05849  -9.54383  8.34988  1.000 75.89816  ? 40  GLU B N   1 
ATOM   2186 C  CA  . GLU B 1 40  ? 26.56808  -10.34965 7.23992  1.000 84.24413  ? 40  GLU B CA  1 
ATOM   2187 C  C   . GLU B 1 40  ? 25.19812  -9.92551  6.74360  1.000 81.10941  ? 40  GLU B C   1 
ATOM   2188 O  O   . GLU B 1 40  ? 24.66930  -10.54985 5.82869  1.000 87.22848  ? 40  GLU B O   1 
ATOM   2189 C  CB  . GLU B 1 40  ? 26.51900  -11.82817 7.63944  1.000 79.52159  ? 40  GLU B CB  1 
ATOM   2190 C  CG  . GLU B 1 40  ? 27.84739  -12.40347 8.07704  1.000 79.93615  ? 40  GLU B CG  1 
ATOM   2191 C  CD  . GLU B 1 40  ? 28.89424  -12.38699 6.96814  1.000 97.57367  ? 40  GLU B CD  1 
ATOM   2192 O  OE1 . GLU B 1 40  ? 28.51385  -12.38454 5.77646  1.000 99.72973  ? 40  GLU B OE1 1 
ATOM   2193 O  OE2 . GLU B 1 40  ? 30.10431  -12.37496 7.28811  1.000 99.28302  ? 40  GLU B OE2 1 
ATOM   2194 N  N   . ASN B 1 41  ? 24.62096  -8.87346  7.29081  1.000 71.03000  ? 41  ASN B N   1 
ATOM   2195 C  CA  . ASN B 1 41  ? 23.22781  -8.55441  7.03087  1.000 67.87000  ? 41  ASN B CA  1 
ATOM   2196 C  C   . ASN B 1 41  ? 23.01582  -7.04575  6.96994  1.000 78.43296  ? 41  ASN B C   1 
ATOM   2197 O  O   . ASN B 1 41  ? 22.18645  -6.47480  7.67753  1.000 83.33000  ? 41  ASN B O   1 
ATOM   2198 C  CB  . ASN B 1 41  ? 22.36392  -9.21176  8.07496  1.000 61.16451  ? 41  ASN B CB  1 
ATOM   2199 C  CG  . ASN B 1 41  ? 20.92615  -9.24362  7.66105  1.000 77.89929  ? 41  ASN B CG  1 
ATOM   2200 O  OD1 . ASN B 1 41  ? 20.54965  -9.99618  6.73137  1.000 102.76903 ? 41  ASN B OD1 1 
ATOM   2201 N  ND2 . ASN B 1 41  ? 20.07485  -8.42889  8.33983  1.000 76.36168  ? 41  ASN B ND2 1 
ATOM   2202 N  N   . LEU B 1 42  ? 23.78704  -6.40854  6.09577  1.000 76.61959  ? 42  LEU B N   1 
ATOM   2203 C  CA  . LEU B 1 42  ? 23.67480  -4.99216  5.80803  1.000 81.83954  ? 42  LEU B CA  1 
ATOM   2204 C  C   . LEU B 1 42  ? 23.17992  -4.82718  4.37831  1.000 92.76042  ? 42  LEU B C   1 
ATOM   2205 O  O   . LEU B 1 42  ? 23.40786  -5.69316  3.53033  1.000 92.91703  ? 42  LEU B O   1 
ATOM   2206 C  CB  . LEU B 1 42  ? 25.00995  -4.27588  6.02862  1.000 77.83357  ? 42  LEU B CB  1 
ATOM   2207 C  CG  . LEU B 1 42  ? 25.73018  -4.65114  7.33111  1.000 70.92328  ? 42  LEU B CG  1 
ATOM   2208 C  CD1 . LEU B 1 42  ? 27.02777  -3.89518  7.46297  1.000 58.38009  ? 42  LEU B CD1 1 
ATOM   2209 C  CD2 . LEU B 1 42  ? 24.83585  -4.42219  8.55483  1.000 68.66478  ? 42  LEU B CD2 1 
ATOM   2210 N  N   . GLU B 1 43  ? 22.49600  -3.70963  4.12405  1.000 93.05706  ? 43  GLU B N   1 
ATOM   2211 C  CA  . GLU B 1 43  ? 21.95390  -3.40740  2.80775  1.000 91.72424  ? 43  GLU B CA  1 
ATOM   2212 C  C   . GLU B 1 43  ? 22.96185  -2.60977  1.98649  1.000 94.58369  ? 43  GLU B C   1 
ATOM   2213 O  O   . GLU B 1 43  ? 23.79792  -1.88110  2.52815  1.000 88.26030  ? 43  GLU B O   1 
ATOM   2214 C  CB  . GLU B 1 43  ? 20.63896  -2.63106  2.92608  1.000 91.98514  ? 43  GLU B CB  1 
ATOM   2215 C  CG  . GLU B 1 43  ? 19.48416  -3.42631  3.52218  1.000 92.50167  ? 43  GLU B CG  1 
ATOM   2216 C  CD  . GLU B 1 43  ? 19.22528  -4.72986  2.78337  1.000 109.07758 ? 43  GLU B CD  1 
ATOM   2217 O  OE1 . GLU B 1 43  ? 19.13751  -4.71125  1.52996  1.000 110.00456 ? 43  GLU B OE1 1 
ATOM   2218 O  OE2 . GLU B 1 43  ? 19.11816  -5.77733  3.46229  1.000 108.24485 ? 43  GLU B OE2 1 
ATOM   2219 N  N   . THR B 1 44  ? 22.86229  -2.74532  0.66588  1.000 91.49540  ? 44  THR B N   1 
ATOM   2220 C  CA  . THR B 1 44  ? 23.82553  -2.14126  -0.24215 1.000 95.37098  ? 44  THR B CA  1 
ATOM   2221 C  C   . THR B 1 44  ? 23.60607  -0.62968  -0.34250 1.000 96.36770  ? 44  THR B C   1 
ATOM   2222 O  O   . THR B 1 44  ? 22.62087  -0.07901  0.15834  1.000 101.50796 ? 44  THR B O   1 
ATOM   2223 C  CB  . THR B 1 44  ? 23.72164  -2.79311  -1.62046 1.000 100.74447 ? 44  THR B CB  1 
ATOM   2224 O  OG1 . THR B 1 44  ? 23.31842  -4.16101  -1.46241 1.000 101.18836 ? 44  THR B OG1 1 
ATOM   2225 C  CG2 . THR B 1 44  ? 25.06670  -2.74918  -2.34492 1.000 98.46398  ? 44  THR B CG2 1 
ATOM   2226 N  N   . ASP B 1 45  ? 24.55484  0.03792   -0.99817 1.000 94.44656  ? 45  ASP B N   1 
ATOM   2227 C  CA  . ASP B 1 45  ? 24.49363  1.47285   -1.25727 1.000 94.41551  ? 45  ASP B CA  1 
ATOM   2228 C  C   . ASP B 1 45  ? 24.31236  2.26324   0.03263  1.000 90.86739  ? 45  ASP B C   1 
ATOM   2229 O  O   . ASP B 1 45  ? 25.27190  2.48327   0.76687  1.000 94.26742  ? 45  ASP B O   1 
ATOM   2230 C  CB  . ASP B 1 45  ? 23.36557  1.80108   -2.24693 1.000 96.38913  ? 45  ASP B CB  1 
ATOM   2231 C  CG  . ASP B 1 45  ? 23.65413  1.30196   -3.66096 1.000 95.06907  ? 45  ASP B CG  1 
ATOM   2232 O  OD1 . ASP B 1 45  ? 23.51492  0.08313   -3.90816 1.000 93.80708  ? 45  ASP B OD1 1 
ATOM   2233 O  OD2 . ASP B 1 45  ? 24.01384  2.13326   -4.52550 1.000 82.64188  ? 45  ASP B OD2 1 
ATOM   2234 N  N   . PHE B 1 54  ? 31.88687  -2.01670  -3.64797 1.000 85.94135  ? 54  PHE B N   1 
ATOM   2235 C  CA  . PHE B 1 54  ? 30.62332  -2.38256  -3.01202 1.000 82.28937  ? 54  PHE B CA  1 
ATOM   2236 C  C   . PHE B 1 54  ? 30.65717  -2.12595  -1.49472 1.000 89.51953  ? 54  PHE B C   1 
ATOM   2237 O  O   . PHE B 1 54  ? 31.62603  -2.47757  -0.82444 1.000 84.14050  ? 54  PHE B O   1 
ATOM   2238 C  CB  . PHE B 1 54  ? 30.30393  -3.84934  -3.30386 1.000 83.71637  ? 54  PHE B CB  1 
ATOM   2239 C  CG  . PHE B 1 54  ? 30.26039  -4.17948  -4.77382 1.000 103.65006 ? 54  PHE B CG  1 
ATOM   2240 C  CD1 . PHE B 1 54  ? 29.39013  -3.50966  -5.62591 1.000 104.90810 ? 54  PHE B CD1 1 
ATOM   2241 C  CD2 . PHE B 1 54  ? 31.08136  -5.16381  -5.30550 1.000 105.56231 ? 54  PHE B CD2 1 
ATOM   2242 C  CE1 . PHE B 1 54  ? 29.34430  -3.81131  -6.98160 1.000 103.76902 ? 54  PHE B CE1 1 
ATOM   2243 C  CE2 . PHE B 1 54  ? 31.03860  -5.47052  -6.66365 1.000 107.87898 ? 54  PHE B CE2 1 
ATOM   2244 C  CZ  . PHE B 1 54  ? 30.17064  -4.79540  -7.49919 1.000 101.96101 ? 54  PHE B CZ  1 
ATOM   2245 N  N   . ARG B 1 55  ? 29.59705  -1.51475  -0.95770 1.000 90.59305  ? 55  ARG B N   1 
ATOM   2246 C  CA  . ARG B 1 55  ? 29.54095  -1.15165  0.45874  1.000 81.55827  ? 55  ARG B CA  1 
ATOM   2247 C  C   . ARG B 1 55  ? 28.16825  -1.48660  1.02625  1.000 83.51319  ? 55  ARG B C   1 
ATOM   2248 O  O   . ARG B 1 55  ? 27.14809  -1.01627  0.51262  1.000 86.18411  ? 55  ARG B O   1 
ATOM   2249 C  CB  . ARG B 1 55  ? 29.85031  0.33740   0.66386  1.000 81.41400  ? 55  ARG B CB  1 
ATOM   2250 C  CG  . ARG B 1 55  ? 30.15495  0.72986   2.11620  1.000 85.08215  ? 55  ARG B CG  1 
ATOM   2251 C  CD  . ARG B 1 55  ? 30.53125  2.21075   2.25711  1.000 76.47068  ? 55  ARG B CD  1 
ATOM   2252 N  NE  . ARG B 1 55  ? 29.36621  3.07687   2.12079  1.000 79.88272  ? 55  ARG B NE  1 
ATOM   2253 C  CZ  . ARG B 1 55  ? 29.01905  3.72237   1.01510  1.000 88.21729  ? 55  ARG B CZ  1 
ATOM   2254 N  NH1 . ARG B 1 55  ? 29.76058  3.67191   -0.08130 1.000 87.35382  ? 55  ARG B NH1 1 
ATOM   2255 N  NH2 . ARG B 1 55  ? 27.89739  4.43772   1.00973  1.000 86.37966  ? 55  ARG B NH2 1 
ATOM   2256 N  N   . GLU B 1 56  ? 28.14966  -2.29315  2.08441  1.000 75.94901  ? 56  GLU B N   1 
ATOM   2257 C  CA  . GLU B 1 56  ? 26.93790  -2.64545  2.80796  1.000 75.80293  ? 56  GLU B CA  1 
ATOM   2258 C  C   . GLU B 1 56  ? 26.94907  -1.96650  4.16933  1.000 71.22198  ? 56  GLU B C   1 
ATOM   2259 O  O   . GLU B 1 56  ? 27.95238  -2.00875  4.88548  1.000 69.86379  ? 56  GLU B O   1 
ATOM   2260 C  CB  . GLU B 1 56  ? 26.82510  -4.15484  2.99472  1.000 76.24250  ? 56  GLU B CB  1 
ATOM   2261 C  CG  . GLU B 1 56  ? 26.62803  -4.93833  1.72454  1.000 78.39426  ? 56  GLU B CG  1 
ATOM   2262 C  CD  . GLU B 1 56  ? 26.50544  -6.42457  2.00450  1.000 78.87827  ? 56  GLU B CD  1 
ATOM   2263 O  OE1 . GLU B 1 56  ? 27.19387  -6.91716  2.92199  1.000 79.15350  ? 56  GLU B OE1 1 
ATOM   2264 O  OE2 . GLU B 1 56  ? 25.70659  -7.10146  1.32562  1.000 87.46158  ? 56  GLU B OE2 1 
ATOM   2265 N  N   . ARG B 1 57  ? 25.83235  -1.35210  4.54099  1.000 73.85349  ? 57  ARG B N   1 
ATOM   2266 C  CA  . ARG B 1 57  ? 25.86505  -0.50628  5.71986  1.000 65.48136  ? 57  ARG B CA  1 
ATOM   2267 C  C   . ARG B 1 57  ? 24.54817  -0.55158  6.48229  1.000 64.94233  ? 57  ARG B C   1 
ATOM   2268 O  O   . ARG B 1 57  ? 23.50875  -0.97122  5.96508  1.000 62.72692  ? 57  ARG B O   1 
ATOM   2269 C  CB  . ARG B 1 57  ? 26.21610  0.93432   5.34714  1.000 64.88376  ? 57  ARG B CB  1 
ATOM   2270 C  CG  . ARG B 1 57  ? 25.35428  1.52982   4.26506  1.000 71.67142  ? 57  ARG B CG  1 
ATOM   2271 C  CD  . ARG B 1 57  ? 25.90622  2.88019   3.83055  1.000 77.61370  ? 57  ARG B CD  1 
ATOM   2272 N  NE  . ARG B 1 57  ? 25.83320  3.87905   4.89039  1.000 82.86243  ? 57  ARG B NE  1 
ATOM   2273 C  CZ  . ARG B 1 57  ? 26.36523  5.09192   4.81258  1.000 87.05840  ? 57  ARG B CZ  1 
ATOM   2274 N  NH1 . ARG B 1 57  ? 27.03339  5.48505   3.74037  1.000 88.00989  ? 57  ARG B NH1 1 
ATOM   2275 N  NH2 . ARG B 1 57  ? 26.22447  5.93162   5.83631  1.000 84.31531  ? 57  ARG B NH2 1 
ATOM   2276 N  N   . ALA B 1 58  ? 24.63681  -0.13267  7.74766  1.000 59.20856  ? 58  ALA B N   1 
ATOM   2277 C  CA  . ALA B 1 58  ? 23.50977  0.09385   8.63939  1.000 52.14573  ? 58  ALA B CA  1 
ATOM   2278 C  C   . ALA B 1 58  ? 23.85081  1.28544   9.53004  1.000 56.20912  ? 58  ALA B C   1 
ATOM   2279 O  O   . ALA B 1 58  ? 25.02558  1.55580   9.79613  1.000 50.34281  ? 58  ALA B O   1 
ATOM   2280 C  CB  . ALA B 1 58  ? 23.19539  -1.15321  9.47980  1.000 59.67828  ? 58  ALA B CB  1 
ATOM   2281 N  N   . TYR B 1 59  ? 22.82199  1.99773   9.99827  1.000 55.83804  ? 59  TYR B N   1 
ATOM   2282 C  CA  . TYR B 1 59  ? 23.06362  3.31405   10.57481 1.000 56.15587  ? 59  TYR B CA  1 
ATOM   2283 C  C   . TYR B 1 59  ? 21.94359  3.72152   11.52069 1.000 62.74918  ? 59  TYR B C   1 
ATOM   2284 O  O   . TYR B 1 59  ? 20.76891  3.47667   11.23313 1.000 60.68577  ? 59  TYR B O   1 
ATOM   2285 C  CB  . TYR B 1 59  ? 23.19737  4.35531   9.46901  1.000 55.60631  ? 59  TYR B CB  1 
ATOM   2286 C  CG  . TYR B 1 59  ? 23.15507  5.78219   9.94304  1.000 54.63133  ? 59  TYR B CG  1 
ATOM   2287 C  CD1 . TYR B 1 59  ? 24.27495  6.36604   10.50667 1.000 52.71464  ? 59  TYR B CD1 1 
ATOM   2288 C  CD2 . TYR B 1 59  ? 22.00926  6.56194   9.78268  1.000 58.31038  ? 59  TYR B CD2 1 
ATOM   2289 C  CE1 . TYR B 1 59  ? 24.26425  7.67328   10.91748 1.000 60.43410  ? 59  TYR B CE1 1 
ATOM   2290 C  CE2 . TYR B 1 59  ? 21.98236  7.88555   10.19707 1.000 54.77891  ? 59  TYR B CE2 1 
ATOM   2291 C  CZ  . TYR B 1 59  ? 23.11889  8.43312   10.76825 1.000 60.18597  ? 59  TYR B CZ  1 
ATOM   2292 O  OH  . TYR B 1 59  ? 23.14434  9.74366   11.19198 1.000 67.12633  ? 59  TYR B OH  1 
ATOM   2293 N  N   . ASP B 1 60  ? 22.32220  4.36890   12.62895 1.000 55.26323  ? 60  ASP B N   1 
ATOM   2294 C  CA  . ASP B 1 60  ? 21.37481  4.99907   13.53813 1.000 48.83627  ? 60  ASP B CA  1 
ATOM   2295 C  C   . ASP B 1 60  ? 22.11629  6.02503   14.36951 1.000 43.43073  ? 60  ASP B C   1 
ATOM   2296 O  O   . ASP B 1 60  ? 23.34683  6.05792   14.39797 1.000 42.06503  ? 60  ASP B O   1 
ATOM   2297 C  CB  . ASP B 1 60  ? 20.67206  3.97937   14.42935 1.000 46.96457  ? 60  ASP B CB  1 
ATOM   2298 C  CG  . ASP B 1 60  ? 19.33472  3.55314   13.86085 1.000 51.25498  ? 60  ASP B CG  1 
ATOM   2299 O  OD1 . ASP B 1 60  ? 18.51638  4.44416   13.55558 1.000 49.58615  ? 60  ASP B OD1 1 
ATOM   2300 O  OD2 . ASP B 1 60  ? 19.11826  2.33805   13.67851 1.000 55.60111  ? 60  ASP B OD2 1 
ATOM   2301 N  N   . ARG B 1 61  ? 21.34365  6.88089   15.02824 1.000 41.99241  ? 61  ARG B N   1 
ATOM   2302 C  CA  . ARG B 1 61  ? 21.87602  7.92256   15.88905 1.000 42.14299  ? 61  ARG B CA  1 
ATOM   2303 C  C   . ARG B 1 61  ? 21.33723  7.74763   17.30524 1.000 50.84096  ? 61  ARG B C   1 
ATOM   2304 O  O   . ARG B 1 61  ? 20.23605  7.22403   17.51380 1.000 38.92259  ? 61  ARG B O   1 
ATOM   2305 C  CB  . ARG B 1 61  ? 21.51711  9.31589   15.37505 1.000 50.76203  ? 61  ARG B CB  1 
ATOM   2306 C  CG  . ARG B 1 61  ? 21.92006  9.56960   13.93850 1.000 52.10048  ? 61  ARG B CG  1 
ATOM   2307 C  CD  . ARG B 1 61  ? 21.42529  10.92097  13.44507 1.000 57.52833  ? 61  ARG B CD  1 
ATOM   2308 N  NE  . ARG B 1 61  ? 22.37574  12.00753  13.67220 1.000 66.59349  ? 61  ARG B NE  1 
ATOM   2309 C  CZ  . ARG B 1 61  ? 23.19342  12.51051  12.75241 1.000 76.08595  ? 61  ARG B CZ  1 
ATOM   2310 N  NH1 . ARG B 1 61  ? 23.24362  12.01963  11.52254 1.000 63.83639  ? 61  ARG B NH1 1 
ATOM   2311 N  NH2 . ARG B 1 61  ? 23.97702  13.53808  13.07334 1.000 70.78047  ? 61  ARG B NH2 1 
ATOM   2312 N  N   . PHE B 1 62  ? 22.11981  8.21518   18.27393 1.000 43.73275  ? 62  PHE B N   1 
ATOM   2313 C  CA  . PHE B 1 62  ? 21.79231  8.07563   19.67768 1.000 42.69600  ? 62  PHE B CA  1 
ATOM   2314 C  C   . PHE B 1 62  ? 21.87260  9.41900   20.37641 1.000 46.71464  ? 62  PHE B C   1 
ATOM   2315 O  O   . PHE B 1 62  ? 22.79136  10.20538  20.13605 1.000 48.66027  ? 62  PHE B O   1 
ATOM   2316 C  CB  . PHE B 1 62  ? 22.71857  7.07011   20.35770 1.000 42.72250  ? 62  PHE B CB  1 
ATOM   2317 C  CG  . PHE B 1 62  ? 22.50576  5.66597   19.88304 1.000 45.50388  ? 62  PHE B CG  1 
ATOM   2318 C  CD1 . PHE B 1 62  ? 21.44269  4.91993   20.35565 1.000 33.04571  ? 62  PHE B CD1 1 
ATOM   2319 C  CD2 . PHE B 1 62  ? 23.33122  5.11276   18.92416 1.000 45.37002  ? 62  PHE B CD2 1 
ATOM   2320 C  CE1 . PHE B 1 62  ? 21.22312  3.64591   19.90747 1.000 34.71829  ? 62  PHE B CE1 1 
ATOM   2321 C  CE2 . PHE B 1 62  ? 23.11487  3.83095   18.47217 1.000 47.37647  ? 62  PHE B CE2 1 
ATOM   2322 C  CZ  . PHE B 1 62  ? 22.05938  3.09108   18.96854 1.000 44.20750  ? 62  PHE B CZ  1 
ATOM   2323 N  N   . PHE B 1 63  ? 20.87667  9.67352   21.21730 1.000 39.45035  ? 63  PHE B N   1 
ATOM   2324 C  CA  . PHE B 1 63  ? 20.92640  10.73637  22.20506 1.000 44.28790  ? 63  PHE B CA  1 
ATOM   2325 C  C   . PHE B 1 63  ? 21.73937  10.24914  23.40161 1.000 42.80869  ? 63  PHE B C   1 
ATOM   2326 O  O   . PHE B 1 63  ? 21.41340  9.21538   23.98721 1.000 42.40532  ? 63  PHE B O   1 
ATOM   2327 C  CB  . PHE B 1 63  ? 19.49459  11.09534  22.62641 1.000 39.86104  ? 63  PHE B CB  1 
ATOM   2328 C  CG  . PHE B 1 63  ? 19.41569  12.18160  23.65467 1.000 43.19704  ? 63  PHE B CG  1 
ATOM   2329 C  CD1 . PHE B 1 63  ? 19.44994  11.88317  25.01334 1.000 47.63040  ? 63  PHE B CD1 1 
ATOM   2330 C  CD2 . PHE B 1 63  ? 19.29517  13.49777  23.26828 1.000 46.19910  ? 63  PHE B CD2 1 
ATOM   2331 C  CE1 . PHE B 1 63  ? 19.37663  12.88703  25.96136 1.000 43.46515  ? 63  PHE B CE1 1 
ATOM   2332 C  CE2 . PHE B 1 63  ? 19.22397  14.50029  24.20163 1.000 48.86199  ? 63  PHE B CE2 1 
ATOM   2333 C  CZ  . PHE B 1 63  ? 19.25618  14.19410  25.55428 1.000 49.40081  ? 63  PHE B CZ  1 
ATOM   2334 N  N   . PHE B 1 64  ? 22.78296  10.98833  23.77793 1.000 40.90635  ? 64  PHE B N   1 
ATOM   2335 C  CA  . PHE B 1 64  ? 23.74705  10.50314  24.76229 1.000 42.14237  ? 64  PHE B CA  1 
ATOM   2336 C  C   . PHE B 1 64  ? 24.09046  11.59297  25.76700 1.000 41.36461  ? 64  PHE B C   1 
ATOM   2337 O  O   . PHE B 1 64  ? 24.36231  12.73192  25.37658 1.000 42.24916  ? 64  PHE B O   1 
ATOM   2338 C  CB  . PHE B 1 64  ? 25.02734  10.00104  24.06415 1.000 34.40145  ? 64  PHE B CB  1 
ATOM   2339 C  CG  . PHE B 1 64  ? 26.15482  9.60062   25.01256 1.000 42.34641  ? 64  PHE B CG  1 
ATOM   2340 C  CD1 . PHE B 1 64  ? 25.93516  8.71927   26.07661 1.000 40.34697  ? 64  PHE B CD1 1 
ATOM   2341 C  CD2 . PHE B 1 64  ? 27.44947  10.07965  24.80784 1.000 38.85809  ? 64  PHE B CD2 1 
ATOM   2342 C  CE1 . PHE B 1 64  ? 26.98824  8.34542   26.93103 1.000 38.52142  ? 64  PHE B CE1 1 
ATOM   2343 C  CE2 . PHE B 1 64  ? 28.49611  9.70267   25.63959 1.000 40.80687  ? 64  PHE B CE2 1 
ATOM   2344 C  CZ  . PHE B 1 64  ? 28.26994  8.83546   26.70271 1.000 39.13999  ? 64  PHE B CZ  1 
ATOM   2345 N  N   . VAL B 1 65  ? 24.10270  11.23880  27.05240 1.000 33.81389  ? 65  VAL B N   1 
ATOM   2346 C  CA  . VAL B 1 65  ? 24.59827  12.14891  28.08875 1.000 42.79488  ? 65  VAL B CA  1 
ATOM   2347 C  C   . VAL B 1 65  ? 25.62552  11.42732  28.95229 1.000 37.70757  ? 65  VAL B C   1 
ATOM   2348 O  O   . VAL B 1 65  ? 25.29672  10.46920  29.66324 1.000 36.39131  ? 65  VAL B O   1 
ATOM   2349 C  CB  . VAL B 1 65  ? 23.46620  12.70970  28.96049 1.000 38.62641  ? 65  VAL B CB  1 
ATOM   2350 C  CG1 . VAL B 1 65  ? 24.04727  13.66422  29.99570 1.000 35.78291  ? 65  VAL B CG1 1 
ATOM   2351 C  CG2 . VAL B 1 65  ? 22.41475  13.38757  28.10237 1.000 35.82859  ? 65  VAL B CG2 1 
ATOM   2352 N  N   . PRO B 1 66  ? 26.88175  11.84919  28.92069 1.000 51.29595  ? 66  PRO B N   1 
ATOM   2353 C  CA  . PRO B 1 66  ? 27.91373  11.05998  29.60033 1.000 45.40723  ? 66  PRO B CA  1 
ATOM   2354 C  C   . PRO B 1 66  ? 27.74317  10.96510  31.10877 1.000 35.62840  ? 66  PRO B C   1 
ATOM   2355 O  O   . PRO B 1 66  ? 27.96134  9.88526   31.66929 1.000 37.82453  ? 66  PRO B O   1 
ATOM   2356 C  CB  . PRO B 1 66  ? 29.20354  11.78352  29.19255 1.000 42.35452  ? 66  PRO B CB  1 
ATOM   2357 C  CG  . PRO B 1 66  ? 28.89420  12.34071  27.88772 1.000 36.90526  ? 66  PRO B CG  1 
ATOM   2358 C  CD  . PRO B 1 66  ? 27.47325  12.80835  27.97591 1.000 42.87129  ? 66  PRO B CD  1 
ATOM   2359 N  N   A ARG B 1 67  ? 27.34883  12.05556  31.77576 0.524 43.68076  ? 67  ARG B N   1 
ATOM   2360 N  N   B ARG B 1 67  ? 27.35839  12.04516  31.79312 0.476 43.38520  ? 67  ARG B N   1 
ATOM   2361 C  CA  A ARG B 1 67  ? 27.27035  12.05234  33.23990 0.524 43.29033  ? 67  ARG B CA  1 
ATOM   2362 C  CA  B ARG B 1 67  ? 27.31817  11.98940  33.25735 0.476 42.24225  ? 67  ARG B CA  1 
ATOM   2363 C  C   A ARG B 1 67  ? 26.35063  10.95803  33.75059 0.524 37.57325  ? 67  ARG B C   1 
ATOM   2364 C  C   B ARG B 1 67  ? 26.35723  10.91746  33.75022 0.476 38.67474  ? 67  ARG B C   1 
ATOM   2365 O  O   A ARG B 1 67  ? 26.65894  10.28262  34.74254 0.524 44.27241  ? 67  ARG B O   1 
ATOM   2366 O  O   B ARG B 1 67  ? 26.65390  10.19960  34.71541 0.476 45.39449  ? 67  ARG B O   1 
ATOM   2367 C  CB  A ARG B 1 67  ? 26.78625  13.40612  33.75161 0.524 45.16491  ? 67  ARG B CB  1 
ATOM   2368 C  CB  B ARG B 1 67  ? 26.94374  13.34911  33.84142 0.476 45.23414  ? 67  ARG B CB  1 
ATOM   2369 C  CG  A ARG B 1 67  ? 26.76957  13.49263  35.26861 0.524 44.42918  ? 67  ARG B CG  1 
ATOM   2370 C  CG  B ARG B 1 67  ? 26.90441  13.35380  35.36685 0.476 44.37378  ? 67  ARG B CG  1 
ATOM   2371 C  CD  A ARG B 1 67  ? 28.16436  13.73749  35.80564 0.524 46.40882  ? 67  ARG B CD  1 
ATOM   2372 C  CD  B ARG B 1 67  ? 28.09426  12.60386  35.98932 0.476 44.74764  ? 67  ARG B CD  1 
ATOM   2373 N  NE  A ARG B 1 67  ? 28.68631  14.99525  35.29067 0.524 44.57163  ? 67  ARG B NE  1 
ATOM   2374 N  NE  B ARG B 1 67  ? 27.90417  12.41447  37.42107 0.476 47.37228  ? 67  ARG B NE  1 
ATOM   2375 C  CZ  A ARG B 1 67  ? 29.91026  15.44684  35.50901 0.524 43.97769  ? 67  ARG B CZ  1 
ATOM   2376 C  CZ  B ARG B 1 67  ? 27.40778  11.32118  37.98392 0.476 44.62289  ? 67  ARG B CZ  1 
ATOM   2377 N  NH1 A ARG B 1 67  ? 30.76822  14.77547  36.25634 0.524 44.04774  ? 67  ARG B NH1 1 
ATOM   2378 N  NH1 B ARG B 1 67  ? 27.13689  10.23819  37.27054 0.476 40.29458  ? 67  ARG B NH1 1 
ATOM   2379 N  NH2 A ARG B 1 67  ? 30.28303  16.59666  34.95534 0.524 43.91321  ? 67  ARG B NH2 1 
ATOM   2380 N  NH2 B ARG B 1 67  ? 27.17179  11.31929  39.29629 0.476 37.61924  ? 67  ARG B NH2 1 
ATOM   2381 N  N   . THR B 1 68  ? 25.21484  10.77209  33.08786 1.000 33.14426  ? 68  THR B N   1 
ATOM   2382 C  CA  . THR B 1 68  ? 24.26180  9.74768   33.45407 1.000 33.93804  ? 68  THR B CA  1 
ATOM   2383 C  C   . THR B 1 68  ? 24.38167  8.49077   32.60868 1.000 40.15905  ? 68  THR B C   1 
ATOM   2384 O  O   . THR B 1 68  ? 23.77712  7.46657   32.96139 1.000 28.44906  ? 68  THR B O   1 
ATOM   2385 C  CB  . THR B 1 68  ? 22.84809  10.31295  33.34087 1.000 41.71020  ? 68  THR B CB  1 
ATOM   2386 O  OG1 . THR B 1 68  ? 22.61535  10.70693  31.98816 1.000 35.60269  ? 68  THR B OG1 1 
ATOM   2387 C  CG2 . THR B 1 68  ? 22.68624  11.52818  34.28659 1.000 37.93794  ? 68  THR B CG2 1 
ATOM   2388 N  N   . GLY B 1 69  ? 25.13669  8.54356   31.50815 1.000 33.90556  ? 69  GLY B N   1 
ATOM   2389 C  CA  . GLY B 1 69  ? 25.15578  7.42597   30.59563 1.000 28.67040  ? 69  GLY B CA  1 
ATOM   2390 C  C   . GLY B 1 69  ? 23.87934  7.22136   29.83034 1.000 33.75438  ? 69  GLY B C   1 
ATOM   2391 O  O   . GLY B 1 69  ? 23.69296  6.14851   29.23254 1.000 36.52240  ? 69  GLY B O   1 
ATOM   2392 N  N   . GLU B 1 70  ? 22.98555  8.21064   29.84021 1.000 35.38405  ? 70  GLU B N   1 
ATOM   2393 C  CA  . GLU B 1 70  ? 21.71686  8.07819   29.13874 1.000 33.10322  ? 70  GLU B CA  1 
ATOM   2394 C  C   . GLU B 1 70  ? 21.95082  7.89624   27.63909 1.000 34.34775  ? 70  GLU B C   1 
ATOM   2395 O  O   . GLU B 1 70  ? 22.68646  8.65533   27.01016 1.000 35.33736  ? 70  GLU B O   1 
ATOM   2396 C  CB  . GLU B 1 70  ? 20.83836  9.30933   29.39201 1.000 32.03152  ? 70  GLU B CB  1 
ATOM   2397 C  CG  . GLU B 1 70  ? 19.41204  9.16351   28.85810 1.000 31.59587  ? 70  GLU B CG  1 
ATOM   2398 C  CD  . GLU B 1 70  ? 18.60651  10.44672  28.97628 1.000 38.97287  ? 70  GLU B CD  1 
ATOM   2399 O  OE1 . GLU B 1 70  ? 19.20158  11.47586  29.36511 1.000 30.75291  ? 70  GLU B OE1 1 
ATOM   2400 O  OE2 . GLU B 1 70  ? 17.38958  10.43152  28.67918 1.000 28.26948  ? 70  GLU B OE2 1 
ATOM   2401 N  N   . VAL B 1 71  ? 21.30741  6.89289   27.06176 1.000 37.60176  ? 71  VAL B N   1 
ATOM   2402 C  CA  . VAL B 1 71  ? 21.35255  6.64220   25.63189 1.000 29.78814  ? 71  VAL B CA  1 
ATOM   2403 C  C   . VAL B 1 71  ? 19.92695  6.39580   25.15428 1.000 35.14587  ? 71  VAL B C   1 
ATOM   2404 O  O   . VAL B 1 71  ? 19.20417  5.58206   25.73941 1.000 37.76363  ? 71  VAL B O   1 
ATOM   2405 C  CB  . VAL B 1 71  ? 22.25990  5.44328   25.29660 1.000 25.18369  ? 71  VAL B CB  1 
ATOM   2406 C  CG1 . VAL B 1 71  ? 22.19879  5.13111   23.83524 1.000 28.49044  ? 71  VAL B CG1 1 
ATOM   2407 C  CG2 . VAL B 1 71  ? 23.68121  5.72577   25.72233 1.000 30.02784  ? 71  VAL B CG2 1 
ATOM   2408 N  N   . ARG B 1 72  ? 19.53107  7.09045   24.08693 1.000 41.69609  ? 72  ARG B N   1 
ATOM   2409 C  CA  . ARG B 1 72  ? 18.20120  6.98703   23.49408 1.000 36.07574  ? 72  ARG B CA  1 
ATOM   2410 C  C   . ARG B 1 72  ? 18.36162  6.80138   21.99273 1.000 39.91198  ? 72  ARG B C   1 
ATOM   2411 O  O   . ARG B 1 72  ? 19.07342  7.57792   21.34392 1.000 41.94010  ? 72  ARG B O   1 
ATOM   2412 C  CB  . ARG B 1 72  ? 17.35803  8.24364   23.77606 1.000 36.99153  ? 72  ARG B CB  1 
ATOM   2413 C  CG  . ARG B 1 72  ? 17.15786  8.62384   25.24153 1.000 37.57408  ? 72  ARG B CG  1 
ATOM   2414 C  CD  . ARG B 1 72  ? 16.46994  10.01760  25.43004 1.000 27.01026  ? 72  ARG B CD  1 
ATOM   2415 N  NE  . ARG B 1 72  ? 15.19856  10.11657  24.72388 1.000 37.23107  ? 72  ARG B NE  1 
ATOM   2416 C  CZ  . ARG B 1 72  ? 14.01124  9.80249   25.22579 1.000 48.21669  ? 72  ARG B CZ  1 
ATOM   2417 N  NH1 . ARG B 1 72  ? 13.86961  9.38100   26.47679 1.000 43.97696  ? 72  ARG B NH1 1 
ATOM   2418 N  NH2 . ARG B 1 72  ? 12.93549  9.91392   24.45199 1.000 57.18014  ? 72  ARG B NH2 1 
ATOM   2419 N  N   . LEU B 1 73  ? 17.70438  5.78074   21.44149 1.000 47.90330  ? 73  LEU B N   1 
ATOM   2420 C  CA  . LEU B 1 73  ? 17.68964  5.56733   19.99071 1.000 37.54439  ? 73  LEU B CA  1 
ATOM   2421 C  C   . LEU B 1 73  ? 16.87478  6.66698   19.32716 1.000 46.03685  ? 73  LEU B C   1 
ATOM   2422 O  O   . LEU B 1 73  ? 15.65120  6.71305   19.48772 1.000 48.56558  ? 73  LEU B O   1 
ATOM   2423 C  CB  . LEU B 1 73  ? 17.09905  4.20033   19.65400 1.000 31.33176  ? 73  LEU B CB  1 
ATOM   2424 C  CG  . LEU B 1 73  ? 16.74886  3.93777   18.18647 1.000 38.38555  ? 73  LEU B CG  1 
ATOM   2425 C  CD1 . LEU B 1 73  ? 18.00853  3.95133   17.33450 1.000 49.55992  ? 73  LEU B CD1 1 
ATOM   2426 C  CD2 . LEU B 1 73  ? 15.97547  2.62419   17.97912 1.000 30.95350  ? 73  LEU B CD2 1 
ATOM   2427 N  N   . ARG B 1 74  ? 17.55088  7.56625   18.57621 1.000 50.20312  ? 74  ARG B N   1 
ATOM   2428 C  CA  . ARG B 1 74  ? 16.86063  8.63378   17.86247 1.000 45.66755  ? 74  ARG B CA  1 
ATOM   2429 C  C   . ARG B 1 74  ? 16.09901  8.07077   16.66204 1.000 43.26249  ? 74  ARG B C   1 
ATOM   2430 O  O   . ARG B 1 74  ? 16.48769  7.04146   16.09938 1.000 41.74827  ? 74  ARG B O   1 
ATOM   2431 C  CB  . ARG B 1 74  ? 17.84682  9.69379   17.38972 1.000 50.57004  ? 74  ARG B CB  1 
ATOM   2432 C  CG  . ARG B 1 74  ? 18.54569  10.42258  18.49866 1.000 49.81132  ? 74  ARG B CG  1 
ATOM   2433 C  CD  . ARG B 1 74  ? 19.34885  11.59203  17.94630 1.000 50.65073  ? 74  ARG B CD  1 
ATOM   2434 N  NE  . ARG B 1 74  ? 18.49954  12.68187  17.47749 1.000 59.82593  ? 74  ARG B NE  1 
ATOM   2435 C  CZ  . ARG B 1 74  ? 18.94527  13.77863  16.87550 1.000 63.68950  ? 74  ARG B CZ  1 
ATOM   2436 N  NH1 . ARG B 1 74  ? 20.23394  13.95785  16.62128 1.000 55.44680  ? 74  ARG B NH1 1 
ATOM   2437 N  NH2 . ARG B 1 74  ? 18.07696  14.72004  16.51975 1.000 66.93647  ? 74  ARG B NH2 1 
ATOM   2438 N  N   . PRO B 1 75  ? 15.00510  8.72088   16.25171 1.000 52.97261  ? 75  PRO B N   1 
ATOM   2439 C  CA  . PRO B 1 75  ? 14.23173  8.19279   15.11743 1.000 56.73919  ? 75  PRO B CA  1 
ATOM   2440 C  C   . PRO B 1 75  ? 15.07504  8.21143   13.84934 1.000 40.83552  ? 75  PRO B C   1 
ATOM   2441 O  O   . PRO B 1 75  ? 15.84707  9.14111   13.60736 1.000 43.94622  ? 75  PRO B O   1 
ATOM   2442 C  CB  . PRO B 1 75  ? 13.02444  9.14080   15.02383 1.000 46.42713  ? 75  PRO B CB  1 
ATOM   2443 C  CG  . PRO B 1 75  ? 13.11748  10.04732  16.22489 1.000 50.84361  ? 75  PRO B CG  1 
ATOM   2444 C  CD  . PRO B 1 75  ? 14.53632  10.05818  16.65830 1.000 43.55506  ? 75  PRO B CD  1 
ATOM   2445 N  N   . HIS B 1 76  ? 14.93164  7.15828   13.05299 1.000 50.52344  ? 76  HIS B N   1 
ATOM   2446 C  CA  . HIS B 1 76  ? 15.87202  6.86612   11.97678 1.000 61.00302  ? 76  HIS B CA  1 
ATOM   2447 C  C   . HIS B 1 76  ? 15.65945  7.81147   10.79349 1.000 62.85847  ? 76  HIS B C   1 
ATOM   2448 O  O   . HIS B 1 76  ? 14.60155  7.79130   10.15625 1.000 61.50849  ? 76  HIS B O   1 
ATOM   2449 C  CB  . HIS B 1 76  ? 15.70645  5.41112   11.54854 1.000 59.49208  ? 76  HIS B CB  1 
ATOM   2450 C  CG  . HIS B 1 76  ? 16.66915  4.97030   10.49023 1.000 65.71774  ? 76  HIS B CG  1 
ATOM   2451 N  ND1 . HIS B 1 76  ? 18.03235  4.94261   10.68712 1.000 63.99998  ? 76  HIS B ND1 1 
ATOM   2452 C  CD2 . HIS B 1 76  ? 16.46120  4.51690   9.23268  1.000 59.99195  ? 76  HIS B CD2 1 
ATOM   2453 C  CE1 . HIS B 1 76  ? 18.62315  4.49974   9.59218  1.000 67.00849  ? 76  HIS B CE1 1 
ATOM   2454 N  NE2 . HIS B 1 76  ? 17.69155  4.22996   8.69676  1.000 68.68006  ? 76  HIS B NE2 1 
ATOM   2455 N  N   . ARG B 1 77  ? 16.67204  8.62370   10.48991 1.000 68.86714  ? 77  ARG B N   1 
ATOM   2456 C  CA  . ARG B 1 77  ? 16.64068  9.55869   9.36169  1.000 69.37658  ? 77  ARG B CA  1 
ATOM   2457 C  C   . ARG B 1 77  ? 17.81713  9.29384   8.42088  1.000 81.58730  ? 77  ARG B C   1 
ATOM   2458 O  O   . ARG B 1 77  ? 18.96241  9.67434   8.73211  1.000 78.75522  ? 77  ARG B O   1 
ATOM   2459 C  CB  . ARG B 1 77  ? 16.65655  11.01126  9.85891  1.000 68.55396  ? 77  ARG B CB  1 
ATOM   2460 C  CG  . ARG B 1 77  ? 15.67888  11.30531  11.02515 1.000 69.86995  ? 77  ARG B CG  1 
ATOM   2461 C  CD  . ARG B 1 77  ? 15.26709  12.79760  11.16670 1.000 75.37131  ? 77  ARG B CD  1 
ATOM   2462 N  NE  . ARG B 1 77  ? 16.37433  13.70625  11.47592 1.000 91.97808  ? 77  ARG B NE  1 
ATOM   2463 C  CZ  . ARG B 1 77  ? 16.23725  14.88887  12.07013 1.000 85.08009  ? 77  ARG B CZ  1 
ATOM   2464 N  NH1 . ARG B 1 77  ? 15.05183  15.34154  12.44167 1.000 77.67978  ? 77  ARG B NH1 1 
ATOM   2465 N  NH2 . ARG B 1 77  ? 17.31854  15.63236  12.30730 1.000 82.68047  ? 77  ARG B NH2 1 
ATOM   2466 N  N   . PRO B 1 78  ? 17.59367  8.62438   7.26375  1.000 87.25650  ? 78  PRO B N   1 
ATOM   2467 C  CA  . PRO B 1 78  ? 18.59676  8.43087   6.19942  1.000 84.04647  ? 78  PRO B CA  1 
ATOM   2468 C  C   . PRO B 1 78  ? 19.13071  9.74693   5.61841  1.000 75.97370  ? 78  PRO B C   1 
ATOM   2469 O  O   . PRO B 1 78  ? 18.59387  10.23090  4.61465  1.000 65.49360  ? 78  PRO B O   1 
ATOM   2470 C  CB  . PRO B 1 78  ? 17.82879  7.64006   5.12166  1.000 72.95699  ? 78  PRO B CB  1 
ATOM   2471 C  CG  . PRO B 1 78  ? 16.73795  6.94732   5.86098  1.000 78.54319  ? 78  PRO B CG  1 
ATOM   2472 C  CD  . PRO B 1 78  ? 16.34510  7.88823   6.98103  1.000 79.13472  ? 78  PRO B CD  1 
ATOM   2473 N  N   . VAL B 1 96  ? 20.00849  4.85491   4.09146  1.000 65.25106  ? 96  VAL B N   1 
ATOM   2474 C  CA  . VAL B 1 96  ? 20.70907  3.77306   4.78344  1.000 60.97890  ? 96  VAL B CA  1 
ATOM   2475 C  C   . VAL B 1 96  ? 19.73784  2.96326   5.63917  1.000 63.96105  ? 96  VAL B C   1 
ATOM   2476 O  O   . VAL B 1 96  ? 18.70932  3.47348   6.08241  1.000 65.89543  ? 96  VAL B O   1 
ATOM   2477 C  CB  . VAL B 1 96  ? 21.82654  4.32277   5.63197  1.000 51.19869  ? 96  VAL B CB  1 
ATOM   2478 N  N   . ALA B 1 97  ? 20.05778  1.71931   5.85699  1.000 61.20018  ? 97  ALA B N   1 
ATOM   2479 C  CA  . ALA B 1 97  ? 19.13234  0.92663   6.65544  1.000 63.50989  ? 97  ALA B CA  1 
ATOM   2480 C  C   . ALA B 1 97  ? 19.38713  1.12139   8.15207  1.000 62.66819  ? 97  ALA B C   1 
ATOM   2481 O  O   . ALA B 1 97  ? 20.50584  1.44604   8.56184  1.000 58.61561  ? 97  ALA B O   1 
ATOM   2482 C  CB  . ALA B 1 97  ? 19.26247  -0.55014  6.30141  1.000 62.60147  ? 97  ALA B CB  1 
ATOM   2483 N  N   . PRO B 1 98  ? 18.36647  0.95248   8.99299  1.000 63.26680  ? 98  PRO B N   1 
ATOM   2484 C  CA  . PRO B 1 98  ? 18.58076  1.05862   10.44156 1.000 62.84271  ? 98  PRO B CA  1 
ATOM   2485 C  C   . PRO B 1 98  ? 19.28064  -0.17272  10.99695 1.000 57.92596  ? 98  PRO B C   1 
ATOM   2486 O  O   . PRO B 1 98  ? 19.21754  -1.26269  10.42206 1.000 62.16097  ? 98  PRO B O   1 
ATOM   2487 C  CB  . PRO B 1 98  ? 17.15749  1.17321   10.99590 1.000 66.31431  ? 98  PRO B CB  1 
ATOM   2488 C  CG  . PRO B 1 98  ? 16.32583  0.41568   9.99916  1.000 57.75897  ? 98  PRO B CG  1 
ATOM   2489 C  CD  . PRO B 1 98  ? 16.94125  0.75900   8.66403  1.000 64.78388  ? 98  PRO B CD  1 
ATOM   2490 N  N   . LEU B 1 99  ? 19.94815  0.01130   12.13549 1.000 56.17522  ? 99  LEU B N   1 
ATOM   2491 C  CA  . LEU B 1 99  ? 20.59582  -1.10817  12.81148 1.000 46.05552  ? 99  LEU B CA  1 
ATOM   2492 C  C   . LEU B 1 99  ? 19.57485  -2.18880  13.13401 1.000 53.26996  ? 99  LEU B C   1 
ATOM   2493 O  O   . LEU B 1 99  ? 18.43040  -1.89837  13.48757 1.000 64.86889  ? 99  LEU B O   1 
ATOM   2494 C  CB  . LEU B 1 99  ? 21.27591  -0.63201  14.09105 1.000 46.83666  ? 99  LEU B CB  1 
ATOM   2495 C  CG  . LEU B 1 99  ? 22.22791  0.54722   13.90964 1.000 43.28243  ? 99  LEU B CG  1 
ATOM   2496 C  CD1 . LEU B 1 99  ? 22.79575  0.97041   15.23422 1.000 46.62822  ? 99  LEU B CD1 1 
ATOM   2497 C  CD2 . LEU B 1 99  ? 23.33722  0.17009   12.94311 1.000 47.46117  ? 99  LEU B CD2 1 
ATOM   2498 N  N   . SER B 1 100 ? 19.98980  -3.44177  13.00464 1.000 52.88747  ? 100 SER B N   1 
ATOM   2499 C  CA  . SER B 1 100 ? 19.07738  -4.55563  13.19947 1.000 52.79878  ? 100 SER B CA  1 
ATOM   2500 C  C   . SER B 1 100 ? 18.60485  -4.62494  14.64684 1.000 57.20191  ? 100 SER B C   1 
ATOM   2501 O  O   . SER B 1 100 ? 19.20374  -4.05051  15.56190 1.000 63.95832  ? 100 SER B O   1 
ATOM   2502 C  CB  . SER B 1 100 ? 19.73992  -5.88058  12.80925 1.000 56.05522  ? 100 SER B CB  1 
ATOM   2503 O  OG  . SER B 1 100 ? 20.81145  -6.18082  13.68421 1.000 55.25955  ? 100 SER B OG  1 
ATOM   2504 N  N   A ARG B 1 101 ? 17.50367  -5.34933  14.84645 0.523 59.04015  ? 101 ARG B N   1 
ATOM   2505 N  N   B ARG B 1 101 ? 17.50249  -5.34950  14.84300 0.477 59.05080  ? 101 ARG B N   1 
ATOM   2506 C  CA  A ARG B 1 101 ? 16.94865  -5.50120  16.18753 0.523 63.56681  ? 101 ARG B CA  1 
ATOM   2507 C  CA  B ARG B 1 101 ? 16.93977  -5.51118  16.17975 0.477 63.68063  ? 101 ARG B CA  1 
ATOM   2508 C  C   A ARG B 1 101 ? 17.91086  -6.23156  17.11367 0.523 61.75188  ? 101 ARG B C   1 
ATOM   2509 C  C   B ARG B 1 101 ? 17.90346  -6.23563  17.11057 0.477 61.75258  ? 101 ARG B C   1 
ATOM   2510 O  O   A ARG B 1 101 ? 17.97271  -5.92749  18.30895 0.523 60.93517  ? 101 ARG B O   1 
ATOM   2511 O  O   B ARG B 1 101 ? 17.96542  -5.92506  18.30426 0.477 60.92702  ? 101 ARG B O   1 
ATOM   2512 C  CB  A ARG B 1 101 ? 15.61584  -6.24389  16.11348 0.523 60.38946  ? 101 ARG B CB  1 
ATOM   2513 C  CB  B ARG B 1 101 ? 15.61070  -6.26232  16.08494 0.477 60.41063  ? 101 ARG B CB  1 
ATOM   2514 C  CG  A ARG B 1 101 ? 14.49549  -5.62429  16.92618 0.523 67.76862  ? 101 ARG B CG  1 
ATOM   2515 C  CG  B ARG B 1 101 ? 14.81781  -6.35213  17.37425 0.477 68.05657  ? 101 ARG B CG  1 
ATOM   2516 C  CD  A ARG B 1 101 ? 14.22085  -6.42251  18.19736 0.523 70.67950  ? 101 ARG B CD  1 
ATOM   2517 C  CD  B ARG B 1 101 ? 14.70698  -7.79216  17.85233 0.477 65.16359  ? 101 ARG B CD  1 
ATOM   2518 N  NE  A ARG B 1 101 ? 12.81911  -6.34430  18.59038 0.523 66.15336  ? 101 ARG B NE  1 
ATOM   2519 N  NE  B ARG B 1 101 ? 15.79260  -8.14099  18.75930 0.477 64.26963  ? 101 ARG B NE  1 
ATOM   2520 C  CZ  A ARG B 1 101 ? 12.33196  -5.48072  19.46765 0.523 67.02355  ? 101 ARG B CZ  1 
ATOM   2521 C  CZ  B ARG B 1 101 ? 16.22675  -9.37544  18.97076 0.477 65.55918  ? 101 ARG B CZ  1 
ATOM   2522 N  NH1 A ARG B 1 101 ? 13.11220  -4.61390  20.08748 0.523 74.89835  ? 101 ARG B NH1 1 
ATOM   2523 N  NH1 B ARG B 1 101 ? 15.69404  -10.41306 18.34518 0.477 66.03579  ? 101 ARG B NH1 1 
ATOM   2524 N  NH2 A ARG B 1 101 ? 11.02917  -5.49198  19.73388 0.523 70.58499  ? 101 ARG B NH2 1 
ATOM   2525 N  NH2 B ARG B 1 101 ? 17.23086  -9.57270  19.81989 0.477 63.12017  ? 101 ARG B NH2 1 
ATOM   2526 N  N   . THR B 1 102 ? 18.66840  -7.19346  16.58403 1.000 60.84414  ? 102 THR B N   1 
ATOM   2527 C  CA  . THR B 1 102 ? 19.60542  -7.93362  17.42057 1.000 64.35768  ? 102 THR B CA  1 
ATOM   2528 C  C   . THR B 1 102 ? 20.82452  -7.08732  17.76588 1.000 65.85685  ? 102 THR B C   1 
ATOM   2529 O  O   . THR B 1 102 ? 21.30618  -7.12375  18.90522 1.000 65.76804  ? 102 THR B O   1 
ATOM   2530 C  CB  . THR B 1 102 ? 20.01737  -9.23139  16.72381 1.000 66.73416  ? 102 THR B CB  1 
ATOM   2531 O  OG1 . THR B 1 102 ? 20.38996  -8.95117  15.36798 1.000 70.03470  ? 102 THR B OG1 1 
ATOM   2532 C  CG2 . THR B 1 102 ? 18.85958  -10.21861 16.73145 1.000 70.36302  ? 102 THR B CG2 1 
ATOM   2533 N  N   . THR B 1 103 ? 21.34358  -6.33419  16.79219 1.000 60.80513  ? 103 THR B N   1 
ATOM   2534 C  CA  . THR B 1 103 ? 22.38008  -5.34756  17.07354 1.000 55.48262  ? 103 THR B CA  1 
ATOM   2535 C  C   . THR B 1 103 ? 21.98882  -4.48604  18.26586 1.000 57.70214  ? 103 THR B C   1 
ATOM   2536 O  O   . THR B 1 103 ? 22.66824  -4.47027  19.30070 1.000 47.18319  ? 103 THR B O   1 
ATOM   2537 C  CB  . THR B 1 103 ? 22.61432  -4.46683  15.84024 1.000 56.33188  ? 103 THR B CB  1 
ATOM   2538 O  OG1 . THR B 1 103 ? 23.18266  -5.24227  14.77824 1.000 55.87253  ? 103 THR B OG1 1 
ATOM   2539 C  CG2 . THR B 1 103 ? 23.52777  -3.29546  16.16399 1.000 46.09751  ? 103 THR B CG2 1 
ATOM   2540 N  N   . LEU B 1 104 ? 20.86607  -3.77834  18.13208 1.000 59.39145  ? 104 LEU B N   1 
ATOM   2541 C  CA  . LEU B 1 104 ? 20.39580  -2.86620  19.16586 1.000 59.36297  ? 104 LEU B CA  1 
ATOM   2542 C  C   . LEU B 1 104 ? 20.10934  -3.56060  20.49092 1.000 51.67961  ? 104 LEU B C   1 
ATOM   2543 O  O   . LEU B 1 104 ? 20.17104  -2.91027  21.54072 1.000 42.08525  ? 104 LEU B O   1 
ATOM   2544 C  CB  . LEU B 1 104 ? 19.14341  -2.15760  18.67288 1.000 60.67496  ? 104 LEU B CB  1 
ATOM   2545 C  CG  . LEU B 1 104 ? 19.36340  -1.21140  17.49875 1.000 55.06772  ? 104 LEU B CG  1 
ATOM   2546 C  CD1 . LEU B 1 104 ? 18.02658  -0.84466  16.86538 1.000 57.13430  ? 104 LEU B CD1 1 
ATOM   2547 C  CD2 . LEU B 1 104 ? 20.07878  0.03366   18.00651 1.000 41.59146  ? 104 LEU B CD2 1 
ATOM   2548 N  N   . ALA B 1 105 ? 19.78788  -4.85671  20.46829 1.000 55.24143  ? 105 ALA B N   1 
ATOM   2549 C  CA  . ALA B 1 105 ? 19.56359  -5.59182  21.70669 1.000 55.79322  ? 105 ALA B CA  1 
ATOM   2550 C  C   . ALA B 1 105 ? 20.86692  -5.96732  22.39613 1.000 56.82951  ? 105 ALA B C   1 
ATOM   2551 O  O   . ALA B 1 105 ? 20.88452  -6.12800  23.62481 1.000 66.66500  ? 105 ALA B O   1 
ATOM   2552 C  CB  . ALA B 1 105 ? 18.73592  -6.85339  21.44274 1.000 47.19807  ? 105 ALA B CB  1 
ATOM   2553 N  N   . ASN B 1 106 ? 21.94797  -6.08364  21.64144 1.000 55.18695  ? 106 ASN B N   1 
ATOM   2554 C  CA  . ASN B 1 106 ? 23.23336  -6.51317  22.18541 1.000 54.93831  ? 106 ASN B CA  1 
ATOM   2555 C  C   . ASN B 1 106 ? 23.78215  -5.48247  23.16594 1.000 45.21690  ? 106 ASN B C   1 
ATOM   2556 O  O   . ASN B 1 106 ? 24.03155  -4.33548  22.77610 1.000 46.92842  ? 106 ASN B O   1 
ATOM   2557 C  CB  . ASN B 1 106 ? 24.21793  -6.74952  21.04237 1.000 48.47334  ? 106 ASN B CB  1 
ATOM   2558 C  CG  . ASN B 1 106 ? 25.40461  -7.54740  21.46833 1.000 47.67546  ? 106 ASN B CG  1 
ATOM   2559 O  OD1 . ASN B 1 106 ? 26.05362  -7.23639  22.46876 1.000 48.90283  ? 106 ASN B OD1 1 
ATOM   2560 N  ND2 . ASN B 1 106 ? 25.69352  -8.60421  20.72268 1.000 55.25002  ? 106 ASN B ND2 1 
ATOM   2561 N  N   . PRO B 1 107 ? 23.99331  -5.83459  24.43045 1.000 47.26883  ? 107 PRO B N   1 
ATOM   2562 C  CA  . PRO B 1 107 ? 24.46557  -4.82870  25.39266 1.000 42.25509  ? 107 PRO B CA  1 
ATOM   2563 C  C   . PRO B 1 107 ? 25.81930  -4.23675  25.04651 1.000 33.63288  ? 107 PRO B C   1 
ATOM   2564 O  O   . PRO B 1 107 ? 26.17213  -3.18195  25.58964 1.000 38.44889  ? 107 PRO B O   1 
ATOM   2565 C  CB  . PRO B 1 107 ? 24.51603  -5.60815  26.71313 1.000 40.33810  ? 107 PRO B CB  1 
ATOM   2566 C  CG  . PRO B 1 107 ? 24.64759  -7.02678  26.31181 1.000 46.13426  ? 107 PRO B CG  1 
ATOM   2567 C  CD  . PRO B 1 107 ? 23.86836  -7.16599  25.03732 1.000 48.68379  ? 107 PRO B CD  1 
ATOM   2568 N  N   . LEU B 1 108 ? 26.59396  -4.87815  24.16706 1.000 36.76600  ? 108 LEU B N   1 
ATOM   2569 C  CA  . LEU B 1 108 ? 27.93644  -4.37575  23.86382 1.000 40.22176  ? 108 LEU B CA  1 
ATOM   2570 C  C   . LEU B 1 108 ? 27.90985  -3.07892  23.05346 1.000 28.62210  ? 108 LEU B C   1 
ATOM   2571 O  O   . LEU B 1 108 ? 28.83088  -2.26590  23.16696 1.000 28.98047  ? 108 LEU B O   1 
ATOM   2572 C  CB  . LEU B 1 108 ? 28.74537  -5.44262  23.13002 1.000 46.04558  ? 108 LEU B CB  1 
ATOM   2573 C  CG  . LEU B 1 108 ? 30.21212  -5.05923  22.90494 1.000 47.05085  ? 108 LEU B CG  1 
ATOM   2574 C  CD1 . LEU B 1 108 ? 30.90087  -4.74157  24.21719 1.000 33.70009  ? 108 LEU B CD1 1 
ATOM   2575 C  CD2 . LEU B 1 108 ? 30.94456  -6.14605  22.16667 1.000 44.34619  ? 108 LEU B CD2 1 
ATOM   2576 N  N   . LEU B 1 109 ? 26.86267  -2.85603  22.26014 1.000 25.87128  ? 109 LEU B N   1 
ATOM   2577 C  CA  . LEU B 1 109 ? 26.74623  -1.62964  21.48193 1.000 27.09783  ? 109 LEU B CA  1 
ATOM   2578 C  C   . LEU B 1 109 ? 26.82988  -0.39053  22.36928 1.000 40.47032  ? 109 LEU B C   1 
ATOM   2579 O  O   . LEU B 1 109 ? 27.71151  0.45971   22.19297 1.000 41.91009  ? 109 LEU B O   1 
ATOM   2580 C  CB  . LEU B 1 109 ? 25.43409  -1.64082  20.69875 1.000 31.44412  ? 109 LEU B CB  1 
ATOM   2581 C  CG  . LEU B 1 109 ? 25.36117  -0.51176  19.65625 1.000 47.77333  ? 109 LEU B CG  1 
ATOM   2582 C  CD1 . LEU B 1 109 ? 26.60845  -0.52585  18.77492 1.000 45.94862  ? 109 LEU B CD1 1 
ATOM   2583 C  CD2 . LEU B 1 109 ? 24.11092  -0.59804  18.79476 1.000 46.55327  ? 109 LEU B CD2 1 
ATOM   2584 N  N   . THR B 1 110 ? 25.91493  -0.26119  23.33562 1.000 40.35427  ? 110 THR B N   1 
ATOM   2585 C  CA  . THR B 1 110 ? 25.93910  0.94096   24.16179 1.000 39.15111  ? 110 THR B CA  1 
ATOM   2586 C  C   . THR B 1 110 ? 27.03842  0.88939   25.21380 1.000 33.64029  ? 110 THR B C   1 
ATOM   2587 O  O   . THR B 1 110 ? 27.50580  1.94120   25.65821 1.000 34.98149  ? 110 THR B O   1 
ATOM   2588 C  CB  . THR B 1 110 ? 24.57736  1.18146   24.83314 1.000 38.97142  ? 110 THR B CB  1 
ATOM   2589 O  OG1 . THR B 1 110 ? 24.32345  0.15153   25.80051 1.000 46.47294  ? 110 THR B OG1 1 
ATOM   2590 C  CG2 . THR B 1 110 ? 23.46446  1.20288   23.79129 1.000 30.88916  ? 110 THR B CG2 1 
ATOM   2591 N  N   . ARG B 1 111 ? 27.48324  -0.29912  25.61705 1.000 31.36721  ? 111 ARG B N   1 
ATOM   2592 C  CA  . ARG B 1 111 ? 28.64693  -0.36033  26.49861 1.000 31.85153  ? 111 ARG B CA  1 
ATOM   2593 C  C   . ARG B 1 111 ? 29.89215  0.13631   25.78237 1.000 39.24976  ? 111 ARG B C   1 
ATOM   2594 O  O   . ARG B 1 111 ? 30.65072  0.94333   26.33842 1.000 37.44590  ? 111 ARG B O   1 
ATOM   2595 C  CB  . ARG B 1 111 ? 28.84042  -1.77676  27.02492 1.000 39.22486  ? 111 ARG B CB  1 
ATOM   2596 C  CG  . ARG B 1 111 ? 27.88147  -2.13380  28.16556 1.000 35.35072  ? 111 ARG B CG  1 
ATOM   2597 C  CD  . ARG B 1 111 ? 27.84367  -3.64166  28.42294 1.000 35.11205  ? 111 ARG B CD  1 
ATOM   2598 N  NE  . ARG B 1 111 ? 26.83645  -3.94291  29.42889 1.000 47.95840  ? 111 ARG B NE  1 
ATOM   2599 C  CZ  . ARG B 1 111 ? 26.52284  -5.15939  29.83885 1.000 41.63175  ? 111 ARG B CZ  1 
ATOM   2600 N  NH1 . ARG B 1 111 ? 27.12564  -6.22605  29.35395 1.000 40.13000  ? 111 ARG B NH1 1 
ATOM   2601 N  NH2 . ARG B 1 111 ? 25.57183  -5.30720  30.75362 1.000 37.86751  ? 111 ARG B NH2 1 
ATOM   2602 N  N   . LEU B 1 112 ? 30.10068  -0.30127  24.52627 1.000 30.88826  ? 112 LEU B N   1 
ATOM   2603 C  CA  . LEU B 1 112 ? 31.15194  0.29845   23.71340 1.000 29.19776  ? 112 LEU B CA  1 
ATOM   2604 C  C   . LEU B 1 112 ? 30.95970  1.79696   23.60653 1.000 28.95441  ? 112 LEU B C   1 
ATOM   2605 O  O   . LEU B 1 112 ? 31.88034  2.56920   23.88383 1.000 33.43269  ? 112 LEU B O   1 
ATOM   2606 C  CB  . LEU B 1 112 ? 31.19052  -0.32317  22.32155 1.000 35.14758  ? 112 LEU B CB  1 
ATOM   2607 C  CG  . LEU B 1 112 ? 31.90241  -1.66466  22.28352 1.000 33.62120  ? 112 LEU B CG  1 
ATOM   2608 C  CD1 . LEU B 1 112 ? 31.74869  -2.28189  20.92236 1.000 33.51155  ? 112 LEU B CD1 1 
ATOM   2609 C  CD2 . LEU B 1 112 ? 33.35034  -1.50481  22.69141 1.000 30.16416  ? 112 LEU B CD2 1 
ATOM   2610 N  N   . LEU B 1 113 ? 29.75003  2.22965   23.24954 1.000 31.33305  ? 113 LEU B N   1 
ATOM   2611 C  CA  . LEU B 1 113 ? 29.48379  3.66261   23.13778 1.000 35.73761  ? 113 LEU B CA  1 
ATOM   2612 C  C   . LEU B 1 113 ? 29.94570  4.41582   24.37350 1.000 37.28237  ? 113 LEU B C   1 
ATOM   2613 O  O   . LEU B 1 113 ? 30.61324  5.44962   24.26673 1.000 43.43068  ? 113 LEU B O   1 
ATOM   2614 C  CB  . LEU B 1 113 ? 27.99549  3.91638   22.90427 1.000 36.01883  ? 113 LEU B CB  1 
ATOM   2615 C  CG  . LEU B 1 113 ? 27.59885  5.38264   22.69151 1.000 42.69030  ? 113 LEU B CG  1 
ATOM   2616 C  CD1 . LEU B 1 113 ? 26.43930  5.44681   21.71852 1.000 33.13407  ? 113 LEU B CD1 1 
ATOM   2617 C  CD2 . LEU B 1 113 ? 27.22504  6.11044   24.00744 1.000 31.09498  ? 113 LEU B CD2 1 
ATOM   2618 N  N   . ARG B 1 114 ? 29.58134  3.92657   25.56422 1.000 37.17077  ? 114 ARG B N   1 
ATOM   2619 C  CA  . ARG B 1 114 ? 29.90926  4.67474   26.77590 1.000 36.43148  ? 114 ARG B CA  1 
ATOM   2620 C  C   . ARG B 1 114 ? 31.39239  4.57452   27.07217 1.000 32.71937  ? 114 ARG B C   1 
ATOM   2621 O  O   . ARG B 1 114 ? 32.04694  5.57660   27.37162 1.000 37.46134  ? 114 ARG B O   1 
ATOM   2622 C  CB  . ARG B 1 114 ? 29.09310  4.17143   27.98144 1.000 41.22827  ? 114 ARG B CB  1 
ATOM   2623 C  CG  . ARG B 1 114 ? 27.58522  4.37537   27.90380 1.000 38.17802  ? 114 ARG B CG  1 
ATOM   2624 C  CD  . ARG B 1 114 ? 26.87477  3.80472   29.12946 1.000 32.35224  ? 114 ARG B CD  1 
ATOM   2625 N  NE  . ARG B 1 114 ? 25.42977  3.98715   29.03154 1.000 34.09592  ? 114 ARG B NE  1 
ATOM   2626 C  CZ  . ARG B 1 114 ? 24.58430  3.06317   28.59672 1.000 32.84277  ? 114 ARG B CZ  1 
ATOM   2627 N  NH1 . ARG B 1 114 ? 24.98861  1.84816   28.29170 1.000 32.24959  ? 114 ARG B NH1 1 
ATOM   2628 N  NH2 . ARG B 1 114 ? 23.29835  3.36797   28.46495 1.000 35.56103  ? 114 ARG B NH2 1 
ATOM   2629 N  N   . ALA B 1 115 ? 31.93418  3.35893   27.01815 1.000 35.63619  ? 115 ALA B N   1 
ATOM   2630 C  CA  . ALA B 1 115 ? 33.34246  3.16406   27.33784 1.000 34.70674  ? 115 ALA B CA  1 
ATOM   2631 C  C   . ALA B 1 115 ? 34.23587  3.95427   26.38464 1.000 49.11093  ? 115 ALA B C   1 
ATOM   2632 O  O   . ALA B 1 115 ? 35.16647  4.64880   26.81810 1.000 49.26165  ? 115 ALA B O   1 
ATOM   2633 C  CB  . ALA B 1 115 ? 33.67166  1.67415   27.30196 1.000 32.14838  ? 115 ALA B CB  1 
ATOM   2634 N  N   . ASP B 1 116 ? 33.94895  3.87765   25.07941 1.000 37.77468  ? 116 ASP B N   1 
ATOM   2635 C  CA  . ASP B 1 116 ? 34.71286  4.64409   24.09950 1.000 44.16936  ? 116 ASP B CA  1 
ATOM   2636 C  C   . ASP B 1 116 ? 34.83136  6.10189   24.51791 1.000 41.35381  ? 116 ASP B C   1 
ATOM   2637 O  O   . ASP B 1 116 ? 35.91681  6.68908   24.47609 1.000 49.11592  ? 116 ASP B O   1 
ATOM   2638 C  CB  . ASP B 1 116 ? 34.05991  4.55331   22.71383 1.000 38.12868  ? 116 ASP B CB  1 
ATOM   2639 C  CG  . ASP B 1 116 ? 34.17878  3.16960   22.09092 1.000 40.99650  ? 116 ASP B CG  1 
ATOM   2640 O  OD1 . ASP B 1 116 ? 35.05184  2.37973   22.52924 1.000 39.43739  ? 116 ASP B OD1 1 
ATOM   2641 O  OD2 . ASP B 1 116 ? 33.39836  2.86905   21.15551 1.000 40.27382  ? 116 ASP B OD2 1 
ATOM   2642 N  N   . PHE B 1 117 ? 33.71491  6.69722   24.93688 1.000 48.82270  ? 117 PHE B N   1 
ATOM   2643 C  CA  . PHE B 1 117 ? 33.67964  8.13473   25.18827 1.000 52.17673  ? 117 PHE B CA  1 
ATOM   2644 C  C   . PHE B 1 117 ? 34.67093  8.56280   26.26887 1.000 56.37262  ? 117 PHE B C   1 
ATOM   2645 O  O   . PHE B 1 117 ? 35.23832  9.66094   26.18597 1.000 57.15451  ? 117 PHE B O   1 
ATOM   2646 C  CB  . PHE B 1 117 ? 32.26746  8.56966   25.57755 1.000 47.73638  ? 117 PHE B CB  1 
ATOM   2647 C  CG  . PHE B 1 117 ? 32.15075  10.04150  25.86472 1.000 50.06613  ? 117 PHE B CG  1 
ATOM   2648 C  CD1 . PHE B 1 117 ? 32.40968  10.54542  27.13789 1.000 42.80246  ? 117 PHE B CD1 1 
ATOM   2649 C  CD2 . PHE B 1 117 ? 31.81255  10.91952  24.85050 1.000 41.78206  ? 117 PHE B CD2 1 
ATOM   2650 C  CE1 . PHE B 1 117 ? 32.31995  11.89719  27.38758 1.000 42.10375  ? 117 PHE B CE1 1 
ATOM   2651 C  CE2 . PHE B 1 117 ? 31.73202  12.27166  25.08533 1.000 44.90807  ? 117 PHE B CE2 1 
ATOM   2652 C  CZ  . PHE B 1 117 ? 31.98496  12.76500  26.35554 1.000 51.84708  ? 117 PHE B CZ  1 
ATOM   2653 N  N   . GLU B 1 118 ? 34.89751  7.72744   27.28348 1.000 48.38016  ? 118 GLU B N   1 
ATOM   2654 C  CA  . GLU B 1 118 ? 35.83827  8.10596   28.33700 1.000 52.53234  ? 118 GLU B CA  1 
ATOM   2655 C  C   . GLU B 1 118 ? 37.25040  8.37180   27.81108 1.000 57.21215  ? 118 GLU B C   1 
ATOM   2656 O  O   . GLU B 1 118 ? 38.02010  9.08055   28.46921 1.000 44.69000  ? 118 GLU B O   1 
ATOM   2657 C  CB  . GLU B 1 118 ? 35.87455  7.02168   29.41925 1.000 49.02651  ? 118 GLU B CB  1 
ATOM   2658 C  CG  . GLU B 1 118 ? 34.57178  6.90790   30.20732 1.000 55.82839  ? 118 GLU B CG  1 
ATOM   2659 C  CD  . GLU B 1 118 ? 34.09503  8.25140   30.74043 1.000 64.24276  ? 118 GLU B CD  1 
ATOM   2660 O  OE1 . GLU B 1 118 ? 34.90079  8.95125   31.39310 1.000 78.01778  ? 118 GLU B OE1 1 
ATOM   2661 O  OE2 . GLU B 1 118 ? 32.91841  8.61615   30.50171 1.000 59.48104  ? 118 GLU B OE2 1 
ATOM   2662 N  N   . ASN B 1 119 ? 37.60537  7.83757   26.64012 1.000 58.19378  ? 119 ASN B N   1 
ATOM   2663 C  CA  . ASN B 1 119 ? 38.93896  8.01727   26.07335 1.000 62.11893  ? 119 ASN B CA  1 
ATOM   2664 C  C   . ASN B 1 119 ? 39.09780  9.33643   25.33832 1.000 55.01474  ? 119 ASN B C   1 
ATOM   2665 O  O   . ASN B 1 119 ? 40.14002  9.55196   24.71792 1.000 59.55911  ? 119 ASN B O   1 
ATOM   2666 C  CB  . ASN B 1 119 ? 39.28353  6.86890   25.11911 1.000 55.25069  ? 119 ASN B CB  1 
ATOM   2667 C  CG  . ASN B 1 119 ? 39.23700  5.52550   25.79016 1.000 45.43865  ? 119 ASN B CG  1 
ATOM   2668 O  OD1 . ASN B 1 119 ? 40.21511  5.08274   26.37723 1.000 62.37353  ? 119 ASN B OD1 1 
ATOM   2669 N  ND2 . ASN B 1 119 ? 38.09998  4.85828   25.69749 1.000 55.49873  ? 119 ASN B ND2 1 
ATOM   2670 N  N   . PHE B 1 120 ? 38.09110  10.22162  25.39056 1.000 48.19037  ? 120 PHE B N   1 
ATOM   2671 C  CA  . PHE B 1 120 ? 38.12373  11.45727  24.60996 1.000 54.70573  ? 120 PHE B CA  1 
ATOM   2672 C  C   . PHE B 1 120 ? 38.48182  12.64259  25.49198 1.000 64.53445  ? 120 PHE B C   1 
ATOM   2673 O  O   . PHE B 1 120 ? 37.87907  12.82387  26.55726 1.000 60.64888  ? 120 PHE B O   1 
ATOM   2674 C  CB  . PHE B 1 120 ? 36.77543  11.72162  23.94387 1.000 58.22004  ? 120 PHE B CB  1 
ATOM   2675 C  CG  . PHE B 1 120 ? 36.35634  10.67268  22.94099 1.000 56.90019  ? 120 PHE B CG  1 
ATOM   2676 C  CD1 . PHE B 1 120 ? 37.27754  9.81300   22.37768 1.000 53.10812  ? 120 PHE B CD1 1 
ATOM   2677 C  CD2 . PHE B 1 120 ? 35.01843  10.54902  22.57217 1.000 47.74068  ? 120 PHE B CD2 1 
ATOM   2678 C  CE1 . PHE B 1 120 ? 36.86713  8.85053   21.45688 1.000 62.97341  ? 120 PHE B CE1 1 
ATOM   2679 C  CE2 . PHE B 1 120 ? 34.60760  9.60131   21.65198 1.000 42.43500  ? 120 PHE B CE2 1 
ATOM   2680 C  CZ  . PHE B 1 120 ? 35.52637  8.75203   21.09596 1.000 48.66450  ? 120 PHE B CZ  1 
ATOM   2681 N  N   . PRO B 1 121 ? 39.42040  13.48158  25.08746 1.000 73.42920  ? 121 PRO B N   1 
ATOM   2682 C  CA  . PRO B 1 121 ? 39.70166  14.68909  25.86899 1.000 63.75689  ? 121 PRO B CA  1 
ATOM   2683 C  C   . PRO B 1 121 ? 38.62833  15.75396  25.70159 1.000 68.72530  ? 121 PRO B C   1 
ATOM   2684 O  O   . PRO B 1 121 ? 38.73855  16.60017  24.80872 1.000 69.49423  ? 121 PRO B O   1 
ATOM   2685 C  CB  . PRO B 1 121 ? 41.04081  15.15727  25.29535 1.000 69.50143  ? 121 PRO B CB  1 
ATOM   2686 C  CG  . PRO B 1 121 ? 41.00974  14.68819  23.88017 1.000 58.06391  ? 121 PRO B CG  1 
ATOM   2687 C  CD  . PRO B 1 121 ? 40.30935  13.36001  23.91625 1.000 60.35870  ? 121 PRO B CD  1 
ATOM   2688 N  N   . VAL B 1 122 ? 37.59784  15.73647  26.54110 1.000 71.03935  ? 122 VAL B N   1 
ATOM   2689 C  CA  . VAL B 1 122 ? 36.54888  16.76484  26.44063 1.000 76.01301  ? 122 VAL B CA  1 
ATOM   2690 C  C   . VAL B 1 122 ? 37.08476  18.08055  26.99436 1.000 73.02407  ? 122 VAL B C   1 
ATOM   2691 O  O   . VAL B 1 122 ? 37.71505  18.08237  28.06751 1.000 74.71562  ? 122 VAL B O   1 
ATOM   2692 C  CB  . VAL B 1 122 ? 35.28406  16.32189  27.18953 1.000 72.76264  ? 122 VAL B CB  1 
ATOM   2693 C  CG1 . VAL B 1 122 ? 34.13833  17.29838  26.93904 1.000 67.95050  ? 122 VAL B CG1 1 
ATOM   2694 C  CG2 . VAL B 1 122 ? 34.87693  14.90526  26.78588 1.000 68.63262  ? 122 VAL B CG2 1 
ATOM   2695 N  N   . PRO B 1 123 ? 36.87862  19.21323  26.31062 1.000 76.66712  ? 123 PRO B N   1 
ATOM   2696 C  CA  . PRO B 1 123 ? 37.51118  20.46397  26.76525 1.000 73.76652  ? 123 PRO B CA  1 
ATOM   2697 C  C   . PRO B 1 123 ? 36.91893  21.02866  28.04470 1.000 80.24982  ? 123 PRO B C   1 
ATOM   2698 O  O   . PRO B 1 123 ? 37.63709  21.71078  28.79048 1.000 77.48211  ? 123 PRO B O   1 
ATOM   2699 C  CB  . PRO B 1 123 ? 37.29118  21.42111  25.58275 1.000 75.21433  ? 123 PRO B CB  1 
ATOM   2700 C  CG  . PRO B 1 123 ? 36.94442  20.54359  24.41474 1.000 70.50686  ? 123 PRO B CG  1 
ATOM   2701 C  CD  . PRO B 1 123 ? 36.22571  19.37131  25.00038 1.000 73.70256  ? 123 PRO B CD  1 
ATOM   2702 N  N   . GLU B 1 124 ? 35.63747  20.77792  28.32035 1.000 80.17164  ? 124 GLU B N   1 
ATOM   2703 C  CA  . GLU B 1 124 ? 34.95744  21.34430  29.47947 1.000 78.27410  ? 124 GLU B CA  1 
ATOM   2704 C  C   . GLU B 1 124 ? 34.11579  20.28012  30.16322 1.000 76.92961  ? 124 GLU B C   1 
ATOM   2705 O  O   . GLU B 1 124 ? 33.25812  19.65490  29.52672 1.000 70.08050  ? 124 GLU B O   1 
ATOM   2706 C  CB  . GLU B 1 124 ? 34.07517  22.52736  29.07699 1.000 81.97403  ? 124 GLU B CB  1 
ATOM   2707 C  CG  . GLU B 1 124 ? 34.86834  23.70333  28.54641 1.000 87.58477  ? 124 GLU B CG  1 
ATOM   2708 C  CD  . GLU B 1 124 ? 35.78740  24.30744  29.59747 1.000 92.51260  ? 124 GLU B CD  1 
ATOM   2709 O  OE1 . GLU B 1 124 ? 35.38650  24.36609  30.77988 1.000 95.62046  ? 124 GLU B OE1 1 
ATOM   2710 O  OE2 . GLU B 1 124 ? 36.91238  24.71742  29.24420 1.000 95.50799  ? 124 GLU B OE2 1 
ATOM   2711 N  N   . GLU B 1 125 ? 34.35254  20.09659  31.46649 1.000 76.71323  ? 125 GLU B N   1 
ATOM   2712 C  CA  . GLU B 1 125 ? 33.58112  19.12736  32.23371 1.000 71.74002  ? 125 GLU B CA  1 
ATOM   2713 C  C   . GLU B 1 125 ? 32.08890  19.35652  32.07426 1.000 65.06999  ? 125 GLU B C   1 
ATOM   2714 O  O   . GLU B 1 125 ? 31.30892  18.40280  32.12598 1.000 62.88072  ? 125 GLU B O   1 
ATOM   2715 C  CB  . GLU B 1 125 ? 33.96442  19.19387  33.70973 1.000 72.88131  ? 125 GLU B CB  1 
ATOM   2716 C  CG  . GLU B 1 125 ? 33.84674  17.86786  34.43824 1.000 84.31461  ? 125 GLU B CG  1 
ATOM   2717 C  CD  . GLU B 1 125 ? 35.03597  16.95196  34.17039 1.000 96.85734  ? 125 GLU B CD  1 
ATOM   2718 O  OE1 . GLU B 1 125 ? 35.26041  16.57085  32.99488 1.000 87.93227  ? 125 GLU B OE1 1 
ATOM   2719 O  OE2 . GLU B 1 125 ? 35.76417  16.62584  35.14035 1.000 105.59426 ? 125 GLU B OE2 1 
ATOM   2720 N  N   . SER B 1 126 ? 31.67731  20.60816  31.85621 1.000 61.41507  ? 126 SER B N   1 
ATOM   2721 C  CA  . SER B 1 126 ? 30.26384  20.90644  31.65833 1.000 61.96006  ? 126 SER B CA  1 
ATOM   2722 C  C   . SER B 1 126 ? 29.67063  20.14061  30.48370 1.000 66.14470  ? 126 SER B C   1 
ATOM   2723 O  O   . SER B 1 126 ? 28.50310  19.73851  30.53526 1.000 60.60427  ? 126 SER B O   1 
ATOM   2724 C  CB  . SER B 1 126 ? 30.06729  22.39923  31.43895 1.000 71.70434  ? 126 SER B CB  1 
ATOM   2725 O  OG  . SER B 1 126 ? 28.86646  22.64011  30.72115 1.000 82.41110  ? 126 SER B OG  1 
ATOM   2726 N  N   . TRP B 1 127 ? 30.44221  19.94414  29.41286 1.000 68.04218  ? 127 TRP B N   1 
ATOM   2727 C  CA  . TRP B 1 127 ? 29.93737  19.18668  28.27602 1.000 59.13333  ? 127 TRP B CA  1 
ATOM   2728 C  C   . TRP B 1 127 ? 29.53229  17.77700  28.66583 1.000 56.42756  ? 127 TRP B C   1 
ATOM   2729 O  O   . TRP B 1 127 ? 28.72962  17.16223  27.95965 1.000 49.37828  ? 127 TRP B O   1 
ATOM   2730 C  CB  . TRP B 1 127 ? 30.98814  19.11796  27.17194 1.000 73.25401  ? 127 TRP B CB  1 
ATOM   2731 C  CG  . TRP B 1 127 ? 31.25911  20.41518  26.48003 1.000 78.84958  ? 127 TRP B CG  1 
ATOM   2732 C  CD1 . TRP B 1 127 ? 30.87847  21.66153  26.88181 1.000 75.87459  ? 127 TRP B CD1 1 
ATOM   2733 C  CD2 . TRP B 1 127 ? 31.96744  20.58667  25.25241 1.000 77.96680  ? 127 TRP B CD2 1 
ATOM   2734 N  NE1 . TRP B 1 127 ? 31.31525  22.60159  25.98283 1.000 75.32627  ? 127 TRP B NE1 1 
ATOM   2735 C  CE2 . TRP B 1 127 ? 31.98508  21.96580  24.97045 1.000 78.24207  ? 127 TRP B CE2 1 
ATOM   2736 C  CE3 . TRP B 1 127 ? 32.59380  19.70581  24.36528 1.000 76.19602  ? 127 TRP B CE3 1 
ATOM   2737 C  CZ2 . TRP B 1 127 ? 32.60058  22.48388  23.84005 1.000 78.63106  ? 127 TRP B CZ2 1 
ATOM   2738 C  CZ3 . TRP B 1 127 ? 33.20240  20.22046  23.24259 1.000 73.27570  ? 127 TRP B CZ3 1 
ATOM   2739 C  CH2 . TRP B 1 127 ? 33.20233  21.59762  22.98766 1.000 75.84911  ? 127 TRP B CH2 1 
ATOM   2740 N  N   . LEU B 1 128 ? 30.07681  17.24823  29.76526 1.000 55.00438  ? 128 LEU B N   1 
ATOM   2741 C  CA  . LEU B 1 128 ? 29.63645  15.94985  30.25328 1.000 55.37109  ? 128 LEU B CA  1 
ATOM   2742 C  C   . LEU B 1 128 ? 28.15908  15.95268  30.63770 1.000 53.51641  ? 128 LEU B C   1 
ATOM   2743 O  O   . LEU B 1 128 ? 27.53117  14.88896  30.63901 1.000 60.09405  ? 128 LEU B O   1 
ATOM   2744 C  CB  . LEU B 1 128 ? 30.50805  15.52383  31.43247 1.000 44.80319  ? 128 LEU B CB  1 
ATOM   2745 C  CG  . LEU B 1 128 ? 31.99194  15.32217  31.10847 1.000 55.43782  ? 128 LEU B CG  1 
ATOM   2746 C  CD1 . LEU B 1 128 ? 32.70373  14.59395  32.24529 1.000 60.43360  ? 128 LEU B CD1 1 
ATOM   2747 C  CD2 . LEU B 1 128 ? 32.16531  14.56715  29.81561 1.000 54.40431  ? 128 LEU B CD2 1 
ATOM   2748 N  N   . ASP B 1 129 ? 27.58447  17.12289  30.92766 1.000 51.81668  ? 129 ASP B N   1 
ATOM   2749 C  CA  . ASP B 1 129 ? 26.16897  17.25735  31.25451 1.000 57.68751  ? 129 ASP B CA  1 
ATOM   2750 C  C   . ASP B 1 129 ? 25.33429  17.77317  30.08903 1.000 53.78571  ? 129 ASP B C   1 
ATOM   2751 O  O   . ASP B 1 129 ? 24.13665  18.00596  30.26445 1.000 58.77404  ? 129 ASP B O   1 
ATOM   2752 C  CB  . ASP B 1 129 ? 25.97397  18.19139  32.46494 1.000 54.40874  ? 129 ASP B CB  1 
ATOM   2753 C  CG  . ASP B 1 129 ? 26.56577  17.62846  33.76382 1.000 62.42953  ? 129 ASP B CG  1 
ATOM   2754 O  OD1 . ASP B 1 129 ? 26.05678  16.59984  34.27263 1.000 59.32315  ? 129 ASP B OD1 1 
ATOM   2755 O  OD2 . ASP B 1 129 ? 27.54340  18.22396  34.27991 1.000 64.85247  ? 129 ASP B OD2 1 
ATOM   2756 N  N   . ASP B 1 130 ? 25.93433  17.97907  28.89996 1.000 60.83231  ? 130 ASP B N   1 
ATOM   2757 C  CA  . ASP B 1 130 ? 25.09384  18.39555  27.77418 1.000 58.28414  ? 130 ASP B CA  1 
ATOM   2758 C  C   . ASP B 1 130 ? 24.79389  17.21017  26.86208 1.000 47.83904  ? 130 ASP B C   1 
ATOM   2759 O  O   . ASP B 1 130 ? 25.52593  16.22007  26.86944 1.000 52.85049  ? 130 ASP B O   1 
ATOM   2760 C  CB  . ASP B 1 130 ? 25.77092  19.50082  26.95310 1.000 58.69078  ? 130 ASP B CB  1 
ATOM   2761 C  CG  . ASP B 1 130 ? 25.95908  20.79042  27.73707 1.000 73.05409  ? 130 ASP B CG  1 
ATOM   2762 O  OD1 . ASP B 1 130 ? 25.21933  21.02352  28.72614 1.000 80.21436  ? 130 ASP B OD1 1 
ATOM   2763 O  OD2 . ASP B 1 130 ? 26.86040  21.57317  27.36156 1.000 71.23059  ? 130 ASP B OD2 1 
ATOM   2764 N  N   . PRO B 1 131 ? 23.72571  17.24833  26.06830 1.000 38.83657  ? 131 PRO B N   1 
ATOM   2765 C  CA  . PRO B 1 131 ? 23.45927  16.13447  25.15142 1.000 48.67931  ? 131 PRO B CA  1 
ATOM   2766 C  C   . PRO B 1 131 ? 24.53822  16.00244  24.08270 1.000 56.62560  ? 131 PRO B C   1 
ATOM   2767 O  O   . PRO B 1 131 ? 25.23340  16.95711  23.73692 1.000 58.95941  ? 131 PRO B O   1 
ATOM   2768 C  CB  . PRO B 1 131 ? 22.10437  16.49930  24.52542 1.000 46.08522  ? 131 PRO B CB  1 
ATOM   2769 C  CG  . PRO B 1 131 ? 21.51082  17.49193  25.42988 1.000 48.16178  ? 131 PRO B CG  1 
ATOM   2770 C  CD  . PRO B 1 131 ? 22.65486  18.25190  26.02339 1.000 52.52104  ? 131 PRO B CD  1 
ATOM   2771 N  N   . TRP B 1 132 ? 24.66496  14.78618  23.55544 1.000 56.20160  ? 132 TRP B N   1 
ATOM   2772 C  CA  . TRP B 1 132 ? 25.57480  14.46477  22.46491 1.000 47.11696  ? 132 TRP B CA  1 
ATOM   2773 C  C   . TRP B 1 132 ? 24.82986  13.68363  21.39051 1.000 52.74399  ? 132 TRP B C   1 
ATOM   2774 O  O   . TRP B 1 132 ? 24.01425  12.80911  21.70069 1.000 47.94747  ? 132 TRP B O   1 
ATOM   2775 C  CB  . TRP B 1 132 ? 26.75928  13.63372  22.95154 1.000 48.45592  ? 132 TRP B CB  1 
ATOM   2776 C  CG  . TRP B 1 132 ? 27.71471  14.39444  23.78695 1.000 55.23850  ? 132 TRP B CG  1 
ATOM   2777 C  CD1 . TRP B 1 132 ? 27.48546  14.92348  25.01859 1.000 51.11619  ? 132 TRP B CD1 1 
ATOM   2778 C  CD2 . TRP B 1 132 ? 29.07048  14.70823  23.45893 1.000 55.63266  ? 132 TRP B CD2 1 
ATOM   2779 N  NE1 . TRP B 1 132 ? 28.61628  15.54619  25.48263 1.000 48.12342  ? 132 TRP B NE1 1 
ATOM   2780 C  CE2 . TRP B 1 132 ? 29.60107  15.43669  24.53815 1.000 53.18666  ? 132 TRP B CE2 1 
ATOM   2781 C  CE3 . TRP B 1 132 ? 29.88504  14.44983  22.35069 1.000 52.17861  ? 132 TRP B CE3 1 
ATOM   2782 C  CZ2 . TRP B 1 132 ? 30.90638  15.91179  24.54442 1.000 57.97594  ? 132 TRP B CZ2 1 
ATOM   2783 C  CZ3 . TRP B 1 132 ? 31.18120  14.91430  22.36171 1.000 52.87470  ? 132 TRP B CZ3 1 
ATOM   2784 C  CH2 . TRP B 1 132 ? 31.67835  15.64283  23.45063 1.000 57.50651  ? 132 TRP B CH2 1 
ATOM   2785 N  N   . ASP B 1 133 ? 25.10537  13.99573  20.12535 1.000 54.03458  ? 133 ASP B N   1 
ATOM   2786 C  CA  . ASP B 1 133 ? 24.65051  13.15028  19.03122 1.000 49.26696  ? 133 ASP B CA  1 
ATOM   2787 C  C   . ASP B 1 133 ? 25.76240  12.16066  18.71217 1.000 46.59838  ? 133 ASP B C   1 
ATOM   2788 O  O   . ASP B 1 133 ? 26.92353  12.55114  18.57566 1.000 42.47339  ? 133 ASP B O   1 
ATOM   2789 C  CB  . ASP B 1 133 ? 24.27423  13.98188  17.80421 1.000 49.55325  ? 133 ASP B CB  1 
ATOM   2790 C  CG  . ASP B 1 133 ? 23.84369  13.12678  16.63085 1.000 56.42461  ? 133 ASP B CG  1 
ATOM   2791 O  OD1 . ASP B 1 133 ? 22.75931  12.51339  16.69758 1.000 50.48004  ? 133 ASP B OD1 1 
ATOM   2792 O  OD2 . ASP B 1 133 ? 24.60065  13.05757  15.63241 1.000 69.29597  ? 133 ASP B OD2 1 
ATOM   2793 N  N   . VAL B 1 134 ? 25.41674  10.87586  18.66471 1.000 50.81136  ? 134 VAL B N   1 
ATOM   2794 C  CA  . VAL B 1 134 ? 26.38639  9.80669   18.43943 1.000 47.69177  ? 134 VAL B CA  1 
ATOM   2795 C  C   . VAL B 1 134 ? 25.90835  8.98611   17.25194 1.000 53.76826  ? 134 VAL B C   1 
ATOM   2796 O  O   . VAL B 1 134 ? 24.87982  8.30104   17.33653 1.000 44.90662  ? 134 VAL B O   1 
ATOM   2797 C  CB  . VAL B 1 134 ? 26.58627  8.90739   19.66744 1.000 43.16749  ? 134 VAL B CB  1 
ATOM   2798 C  CG1 . VAL B 1 134 ? 27.53763  7.77874   19.31635 1.000 45.46291  ? 134 VAL B CG1 1 
ATOM   2799 C  CG2 . VAL B 1 134 ? 27.12554  9.71246   20.83417 1.000 42.27753  ? 134 VAL B CG2 1 
ATOM   2800 N  N   . GLN B 1 135 ? 26.65257  9.04163   16.15250 1.000 56.68840  ? 135 GLN B N   1 
ATOM   2801 C  CA  . GLN B 1 135 ? 26.28781  8.31557   14.94494 1.000 56.81466  ? 135 GLN B CA  1 
ATOM   2802 C  C   . GLN B 1 135 ? 26.94308  6.94793   14.97937 1.000 49.62509  ? 135 GLN B C   1 
ATOM   2803 O  O   . GLN B 1 135 ? 28.16557  6.84949   15.05373 1.000 53.12309  ? 135 GLN B O   1 
ATOM   2804 C  CB  . GLN B 1 135 ? 26.73137  9.08516   13.71057 1.000 51.16831  ? 135 GLN B CB  1 
ATOM   2805 C  CG  . GLN B 1 135 ? 26.43438  10.55878  13.80893 1.000 62.76271  ? 135 GLN B CG  1 
ATOM   2806 C  CD  . GLN B 1 135 ? 26.93838  11.31433  12.60794 1.000 65.67404  ? 135 GLN B CD  1 
ATOM   2807 O  OE1 . GLN B 1 135 ? 27.09050  10.74803  11.52332 1.000 77.21215  ? 135 GLN B OE1 1 
ATOM   2808 N  NE2 . GLN B 1 135 ? 27.22422  12.59569  12.79534 1.000 65.59884  ? 135 GLN B NE2 1 
ATOM   2809 N  N   . CYS B 1 136 ? 26.14580  5.90313   14.91531 1.000 47.49693  ? 136 CYS B N   1 
ATOM   2810 C  CA  . CYS B 1 136 ? 26.66340  4.54434   14.97022 1.000 52.94689  ? 136 CYS B CA  1 
ATOM   2811 C  C   . CYS B 1 136 ? 26.55764  3.92345   13.58031 1.000 51.84663  ? 136 CYS B C   1 
ATOM   2812 O  O   . CYS B 1 136 ? 25.45118  3.70927   13.07849 1.000 51.81288  ? 136 CYS B O   1 
ATOM   2813 C  CB  . CYS B 1 136 ? 25.90237  3.72926   16.00691 1.000 36.31406  ? 136 CYS B CB  1 
ATOM   2814 S  SG  . CYS B 1 136 ? 26.60454  2.11125   16.25145 1.000 54.67439  ? 136 CYS B SG  1 
ATOM   2815 N  N   . HIS B 1 137 ? 27.70184  3.63014   12.96237 1.000 49.92024  ? 137 HIS B N   1 
ATOM   2816 C  CA  . HIS B 1 137 ? 27.76008  3.15127   11.57999 1.000 45.94760  ? 137 HIS B CA  1 
ATOM   2817 C  C   . HIS B 1 137 ? 28.25397  1.71492   11.54439 1.000 48.00541  ? 137 HIS B C   1 
ATOM   2818 O  O   . HIS B 1 137 ? 29.37792  1.43582   11.97346 1.000 43.99389  ? 137 HIS B O   1 
ATOM   2819 C  CB  . HIS B 1 137 ? 28.69874  4.00781   10.73252 1.000 54.74480  ? 137 HIS B CB  1 
ATOM   2820 C  CG  . HIS B 1 137 ? 28.23922  5.41306   10.54631 1.000 55.98889  ? 137 HIS B CG  1 
ATOM   2821 N  ND1 . HIS B 1 137 ? 28.73229  6.45897   11.29385 1.000 58.19472  ? 137 HIS B ND1 1 
ATOM   2822 C  CD2 . HIS B 1 137 ? 27.33630  5.94798   9.69244  1.000 56.39788  ? 137 HIS B CD2 1 
ATOM   2823 C  CE1 . HIS B 1 137 ? 28.14738  7.58031   10.91019 1.000 65.58244  ? 137 HIS B CE1 1 
ATOM   2824 N  NE2 . HIS B 1 137 ? 27.29340  7.29661   9.94334  1.000 61.50068  ? 137 HIS B NE2 1 
ATOM   2825 N  N   . GLN B 1 138 ? 27.43997  0.81224   11.00975 1.000 42.59097  ? 138 GLN B N   1 
ATOM   2826 C  CA  . GLN B 1 138 ? 27.90707  -0.52237  10.65187 1.000 49.90796  ? 138 GLN B CA  1 
ATOM   2827 C  C   . GLN B 1 138 ? 28.26190  -0.49740  9.16436  1.000 61.25987  ? 138 GLN B C   1 
ATOM   2828 O  O   . GLN B 1 138 ? 27.38016  -0.34922  8.31568  1.000 60.78168  ? 138 GLN B O   1 
ATOM   2829 C  CB  . GLN B 1 138 ? 26.84895  -1.58173  10.95229 1.000 53.71713  ? 138 GLN B CB  1 
ATOM   2830 C  CG  . GLN B 1 138 ? 26.67236  -1.94003  12.42258 1.000 52.91721  ? 138 GLN B CG  1 
ATOM   2831 C  CD  . GLN B 1 138 ? 25.53425  -2.91998  12.64478 1.000 52.00124  ? 138 GLN B CD  1 
ATOM   2832 O  OE1 . GLN B 1 138 ? 24.50674  -2.85625  11.96380 1.000 59.31680  ? 138 GLN B OE1 1 
ATOM   2833 N  NE2 . GLN B 1 138 ? 25.71112  -3.83804  13.59394 1.000 44.07081  ? 138 GLN B NE2 1 
ATOM   2834 N  N   . PHE B 1 139 ? 29.54658  -0.61565  8.84800  1.000 54.46869  ? 139 PHE B N   1 
ATOM   2835 C  CA  . PHE B 1 139 ? 30.01367  -0.65609  7.46803  1.000 58.76477  ? 139 PHE B CA  1 
ATOM   2836 C  C   . PHE B 1 139 ? 30.62131  -2.01507  7.17186  1.000 58.01569  ? 139 PHE B C   1 
ATOM   2837 O  O   . PHE B 1 139 ? 31.44198  -2.51553  7.94816  1.000 55.86924  ? 139 PHE B O   1 
ATOM   2838 C  CB  . PHE B 1 139 ? 31.05297  0.43327   7.18963  1.000 48.21662  ? 139 PHE B CB  1 
ATOM   2839 C  CG  . PHE B 1 139 ? 30.46676  1.80372   7.07589  1.000 58.74155  ? 139 PHE B CG  1 
ATOM   2840 C  CD1 . PHE B 1 139 ? 29.16742  1.97076   6.64429  1.000 72.10065  ? 139 PHE B CD1 1 
ATOM   2841 C  CD2 . PHE B 1 139 ? 31.20767  2.92559   7.40057  1.000 73.06584  ? 139 PHE B CD2 1 
ATOM   2842 C  CE1 . PHE B 1 139 ? 28.60650  3.23276   6.53165  1.000 71.28710  ? 139 PHE B CE1 1 
ATOM   2843 C  CE2 . PHE B 1 139 ? 30.65668  4.19214   7.29333  1.000 77.20031  ? 139 PHE B CE2 1 
ATOM   2844 C  CZ  . PHE B 1 139 ? 29.34929  4.34245   6.85639  1.000 73.79245  ? 139 PHE B CZ  1 
ATOM   2845 N  N   . ARG B 1 140 ? 30.22158  -2.60430  6.05014  1.000 62.84503  ? 140 ARG B N   1 
ATOM   2846 C  CA  . ARG B 1 140 ? 30.96865  -3.68733  5.42778  1.000 64.47421  ? 140 ARG B CA  1 
ATOM   2847 C  C   . ARG B 1 140 ? 31.47746  -3.23525  4.06477  1.000 65.14592  ? 140 ARG B C   1 
ATOM   2848 O  O   . ARG B 1 140 ? 30.69708  -2.75424  3.23566  1.000 61.25764  ? 140 ARG B O   1 
ATOM   2849 C  CB  . ARG B 1 140 ? 30.12154  -4.93673  5.26731  1.000 61.69537  ? 140 ARG B CB  1 
ATOM   2850 C  CG  . ARG B 1 140 ? 30.59618  -5.75467  4.09727  1.000 67.25299  ? 140 ARG B CG  1 
ATOM   2851 C  CD  . ARG B 1 140 ? 30.01211  -7.11194  4.13274  1.000 59.67526  ? 140 ARG B CD  1 
ATOM   2852 N  NE  . ARG B 1 140 ? 30.43754  -7.80626  5.33110  1.000 59.94382  ? 140 ARG B NE  1 
ATOM   2853 C  CZ  . ARG B 1 140 ? 30.05072  -9.02976  5.65005  1.000 68.65327  ? 140 ARG B CZ  1 
ATOM   2854 N  NH1 . ARG B 1 140 ? 29.21180  -9.70675  4.88740  1.000 78.31617  ? 140 ARG B NH1 1 
ATOM   2855 N  NH2 . ARG B 1 140 ? 30.51623  -9.58789  6.76139  1.000 75.00926  ? 140 ARG B NH2 1 
ATOM   2856 N  N   . ILE B 1 141 ? 32.78326  -3.38778  3.83914  1.000 68.06370  ? 141 ILE B N   1 
ATOM   2857 C  CA  . ILE B 1 141 ? 33.41204  -3.08879  2.55415  1.000 70.34305  ? 141 ILE B CA  1 
ATOM   2858 C  C   . ILE B 1 141 ? 33.65749  -4.39736  1.82603  1.000 66.47342  ? 141 ILE B C   1 
ATOM   2859 O  O   . ILE B 1 141 ? 34.10245  -5.38105  2.42961  1.000 61.18329  ? 141 ILE B O   1 
ATOM   2860 C  CB  . ILE B 1 141 ? 34.73139  -2.31400  2.72725  1.000 67.66224  ? 141 ILE B CB  1 
ATOM   2861 C  CG1 . ILE B 1 141 ? 34.54420  -1.12417  3.67930  1.000 65.88723  ? 141 ILE B CG1 1 
ATOM   2862 C  CG2 . ILE B 1 141 ? 35.26760  -1.88219  1.37161  1.000 73.05560  ? 141 ILE B CG2 1 
ATOM   2863 C  CD1 . ILE B 1 141 ? 33.57575  -0.07095  3.19022  1.000 75.94570  ? 141 ILE B CD1 1 
ATOM   2864 N  N   . ILE B 1 142 ? 33.36946  -4.41284  0.52573  1.000 78.23057  ? 142 ILE B N   1 
ATOM   2865 C  CA  . ILE B 1 142 ? 33.49290  -5.61035  -0.30425 1.000 81.54370  ? 142 ILE B CA  1 
ATOM   2866 C  C   . ILE B 1 142 ? 34.29463  -5.26345  -1.55178 1.000 75.07246  ? 142 ILE B C   1 
ATOM   2867 O  O   . ILE B 1 142 ? 33.89877  -4.38111  -2.32479 1.000 77.82558  ? 142 ILE B O   1 
ATOM   2868 C  CB  . ILE B 1 142 ? 32.12472  -6.18178  -0.69883 1.000 81.86910  ? 142 ILE B CB  1 
ATOM   2869 C  CG1 . ILE B 1 142 ? 31.26073  -6.37436  0.54114  1.000 67.97139  ? 142 ILE B CG1 1 
ATOM   2870 C  CG2 . ILE B 1 142 ? 32.30125  -7.49200  -1.45764 1.000 78.88968  ? 142 ILE B CG2 1 
ATOM   2871 C  CD1 . ILE B 1 142 ? 29.79518  -6.53899  0.23044  1.000 74.73971  ? 142 ILE B CD1 1 
ATOM   2872 N  N   . SER B 1 143 ? 35.40091  -5.96801  -1.75877 1.000 70.32769  ? 143 SER B N   1 
ATOM   2873 C  CA  . SER B 1 143 ? 36.26199  -5.71909  -2.90932 1.000 76.10054  ? 143 SER B CA  1 
ATOM   2874 C  C   . SER B 1 143 ? 36.35884  -6.95144  -3.79941 1.000 73.28330  ? 143 SER B C   1 
ATOM   2875 O  O   . SER B 1 143 ? 36.78967  -8.00905  -3.35560 1.000 69.06344  ? 143 SER B O   1 
ATOM   2876 C  CB  . SER B 1 143 ? 37.65524  -5.28954  -2.45405 1.000 75.42528  ? 143 SER B CB  1 
ATOM   2877 O  OG  . SER B 1 143 ? 38.22212  -4.37370  -3.37472 1.000 80.01614  ? 143 SER B OG  1 
ATOM   2878 N  N   . GLU B 1 154 ? 40.47675  7.01802   -0.32993 1.000 67.01402  ? 154 GLU B N   1 
ATOM   2879 C  CA  . GLU B 1 154 ? 39.92256  8.34901   -0.09702 1.000 70.03685  ? 154 GLU B CA  1 
ATOM   2880 C  C   . GLU B 1 154 ? 41.02294  9.35374   0.20918  1.000 68.97774  ? 154 GLU B C   1 
ATOM   2881 O  O   . GLU B 1 154 ? 42.11137  8.97757   0.63567  1.000 68.53490  ? 154 GLU B O   1 
ATOM   2882 C  CB  . GLU B 1 154 ? 38.90855  8.32737   1.06482  1.000 86.78226  ? 154 GLU B CB  1 
ATOM   2883 C  CG  . GLU B 1 154 ? 39.10730  7.19932   2.08947  1.000 76.07217  ? 154 GLU B CG  1 
ATOM   2884 C  CD  . GLU B 1 154 ? 38.15095  7.29961   3.26701  1.000 83.62257  ? 154 GLU B CD  1 
ATOM   2885 O  OE1 . GLU B 1 154 ? 38.22079  8.30619   4.00175  1.000 90.96998  ? 154 GLU B OE1 1 
ATOM   2886 O  OE2 . GLU B 1 154 ? 37.32333  6.38145   3.46067  1.000 83.16648  ? 154 GLU B OE2 1 
ATOM   2887 N  N   . GLY B 1 155 ? 40.74289  10.63262  -0.01848 1.000 71.96857  ? 155 GLY B N   1 
ATOM   2888 C  CA  . GLY B 1 155 ? 41.63957  11.68332  0.39365  1.000 71.27400  ? 155 GLY B CA  1 
ATOM   2889 C  C   . GLY B 1 155 ? 41.39408  12.05194  1.84205  1.000 81.01544  ? 155 GLY B C   1 
ATOM   2890 O  O   . GLY B 1 155 ? 40.39326  11.64719  2.44279  1.000 80.33992  ? 155 GLY B O   1 
ATOM   2891 N  N   . PRO B 1 156 ? 42.30604  12.81757  2.43870  1.000 85.41403  ? 156 PRO B N   1 
ATOM   2892 C  CA  . PRO B 1 156 ? 42.08616  13.27344  3.81662  1.000 77.77435  ? 156 PRO B CA  1 
ATOM   2893 C  C   . PRO B 1 156 ? 40.78216  14.04977  3.93472  1.000 77.17871  ? 156 PRO B C   1 
ATOM   2894 O  O   . PRO B 1 156 ? 40.48413  14.93604  3.13045  1.000 76.66989  ? 156 PRO B O   1 
ATOM   2895 C  CB  . PRO B 1 156 ? 43.30961  14.15723  4.10212  1.000 79.07168  ? 156 PRO B CB  1 
ATOM   2896 C  CG  . PRO B 1 156 ? 43.82943  14.54633  2.76168  1.000 82.17158  ? 156 PRO B CG  1 
ATOM   2897 C  CD  . PRO B 1 156 ? 43.55113  13.36308  1.87269  1.000 85.47242  ? 156 PRO B CD  1 
ATOM   2898 N  N   . HIS B 1 157 ? 39.99093  13.68389  4.93504  1.000 79.72618  ? 157 HIS B N   1 
ATOM   2899 C  CA  . HIS B 1 157 ? 38.75075  14.37503  5.23707  1.000 77.74495  ? 157 HIS B CA  1 
ATOM   2900 C  C   . HIS B 1 157 ? 38.55208  14.31699  6.74307  1.000 76.61382  ? 157 HIS B C   1 
ATOM   2901 O  O   . HIS B 1 157 ? 39.35022  13.71488  7.46904  1.000 71.69975  ? 157 HIS B O   1 
ATOM   2902 C  CB  . HIS B 1 157 ? 37.56918  13.74874  4.48720  1.000 68.52454  ? 157 HIS B CB  1 
ATOM   2903 C  CG  . HIS B 1 157 ? 37.25756  12.35144  4.92002  1.000 69.50794  ? 157 HIS B CG  1 
ATOM   2904 N  ND1 . HIS B 1 157 ? 38.16325  11.56991  5.60379  1.000 75.47626  ? 157 HIS B ND1 1 
ATOM   2905 C  CD2 . HIS B 1 157 ? 36.14127  11.59674  4.77742  1.000 68.76645  ? 157 HIS B CD2 1 
ATOM   2906 C  CE1 . HIS B 1 157 ? 37.61690  10.39605  5.86791  1.000 73.18174  ? 157 HIS B CE1 1 
ATOM   2907 N  NE2 . HIS B 1 157 ? 36.38901  10.38696  5.38209  1.000 68.69905  ? 157 HIS B NE2 1 
ATOM   2908 N  N   . ARG B 1 158 ? 37.47831  14.95092  7.20793  1.000 76.77203  ? 158 ARG B N   1 
ATOM   2909 C  CA  . ARG B 1 158 ? 37.00648  14.80589  8.57638  1.000 71.92173  ? 158 ARG B CA  1 
ATOM   2910 C  C   . ARG B 1 158 ? 35.54257  14.38850  8.54547  1.000 74.58479  ? 158 ARG B C   1 
ATOM   2911 O  O   . ARG B 1 158 ? 34.79525  14.75530  7.63383  1.000 69.03857  ? 158 ARG B O   1 
ATOM   2912 C  CB  . ARG B 1 158 ? 37.15489  16.10515  9.37657  1.000 71.98072  ? 158 ARG B CB  1 
ATOM   2913 C  CG  . ARG B 1 158 ? 36.24439  17.21342  8.87587  1.000 76.07532  ? 158 ARG B CG  1 
ATOM   2914 C  CD  . ARG B 1 158 ? 36.21939  18.36358  9.83989  1.000 75.23630  ? 158 ARG B CD  1 
ATOM   2915 N  NE  . ARG B 1 158 ? 35.89597  17.89863  11.17784 1.000 71.63566  ? 158 ARG B NE  1 
ATOM   2916 C  CZ  . ARG B 1 158 ? 35.69468  18.69780  12.21233 1.000 77.47052  ? 158 ARG B CZ  1 
ATOM   2917 N  NH1 . ARG B 1 158 ? 35.78749  20.01293  12.09624 1.000 82.33755  ? 158 ARG B NH1 1 
ATOM   2918 N  NH2 . ARG B 1 158 ? 35.39167  18.16462  13.39185 1.000 74.93544  ? 158 ARG B NH2 1 
ATOM   2919 N  N   . ASP B 1 159 ? 35.13271  13.61880  9.55145  1.000 72.60707  ? 159 ASP B N   1 
ATOM   2920 C  CA  . ASP B 1 159 ? 33.76790  13.11731  9.61260  1.000 67.69897  ? 159 ASP B CA  1 
ATOM   2921 C  C   . ASP B 1 159 ? 32.78826  14.13893  10.19382 1.000 63.36671  ? 159 ASP B C   1 
ATOM   2922 O  O   . ASP B 1 159 ? 31.61683  13.80886  10.39674 1.000 66.00978  ? 159 ASP B O   1 
ATOM   2923 C  CB  . ASP B 1 159 ? 33.73647  11.79957  10.39558 1.000 66.68823  ? 159 ASP B CB  1 
ATOM   2924 C  CG  . ASP B 1 159 ? 34.36842  10.64242  9.61624  1.000 66.55513  ? 159 ASP B CG  1 
ATOM   2925 O  OD1 . ASP B 1 159 ? 34.59950  10.78844  8.39189  1.000 69.29573  ? 159 ASP B OD1 1 
ATOM   2926 O  OD2 . ASP B 1 159 ? 34.64067  9.57925   10.21566 1.000 67.20540  ? 159 ASP B OD2 1 
ATOM   2927 N  N   . GLU B 1 160 ? 33.23345  15.38036  10.41434 1.000 66.66237  ? 160 GLU B N   1 
ATOM   2928 C  CA  . GLU B 1 160 ? 32.37100  16.49153  10.84625 1.000 79.79992  ? 160 GLU B CA  1 
ATOM   2929 C  C   . GLU B 1 160 ? 31.75708  16.23529  12.22458 1.000 67.46091  ? 160 GLU B C   1 
ATOM   2930 O  O   . GLU B 1 160 ? 30.64550  16.67134  12.51974 1.000 70.01919  ? 160 GLU B O   1 
ATOM   2931 C  CB  . GLU B 1 160 ? 31.27462  16.80621  9.81232  1.000 69.45786  ? 160 GLU B CB  1 
ATOM   2932 C  CG  . GLU B 1 160 ? 31.76242  17.29066  8.44209  1.000 69.78684  ? 160 GLU B CG  1 
ATOM   2933 C  CD  . GLU B 1 160 ? 32.71284  18.49666  8.50083  1.000 85.03507  ? 160 GLU B CD  1 
ATOM   2934 O  OE1 . GLU B 1 160 ? 32.74396  19.22085  9.52279  1.000 87.38140  ? 160 GLU B OE1 1 
ATOM   2935 O  OE2 . GLU B 1 160 ? 33.43482  18.72540  7.50326  1.000 85.33808  ? 160 GLU B OE2 1 
ATOM   2936 N  N   . VAL B 1 161 ? 32.49271  15.53711  13.08318 1.000 63.85529  ? 161 VAL B N   1 
ATOM   2937 C  CA  . VAL B 1 161 ? 32.11405  15.34139  14.47150 1.000 68.38937  ? 161 VAL B CA  1 
ATOM   2938 C  C   . VAL B 1 161 ? 33.24287  15.87726  15.34620 1.000 64.18428  ? 161 VAL B C   1 
ATOM   2939 O  O   . VAL B 1 161 ? 34.26268  16.34193  14.84660 1.000 65.66727  ? 161 VAL B O   1 
ATOM   2940 C  CB  . VAL B 1 161 ? 31.80941  13.86377  14.79349 1.000 63.08970  ? 161 VAL B CB  1 
ATOM   2941 C  CG1 . VAL B 1 161 ? 30.66074  13.35576  13.92929 1.000 50.39117  ? 161 VAL B CG1 1 
ATOM   2942 C  CG2 . VAL B 1 161 ? 33.06070  13.01571  14.59963 1.000 58.09326  ? 161 VAL B CG2 1 
ATOM   2943 N  N   . ASP B 1 162 ? 33.04402  15.82949  16.66207 1.000 55.48163  ? 162 ASP B N   1 
ATOM   2944 C  CA  . ASP B 1 162 ? 34.08010  16.28574  17.58075 1.000 55.53501  ? 162 ASP B CA  1 
ATOM   2945 C  C   . ASP B 1 162 ? 35.08465  15.18070  17.87670 1.000 58.36065  ? 162 ASP B C   1 
ATOM   2946 O  O   . ASP B 1 162 ? 36.28411  15.44916  18.00222 1.000 60.57676  ? 162 ASP B O   1 
ATOM   2947 C  CB  . ASP B 1 162 ? 33.45079  16.79233  18.88884 1.000 56.99400  ? 162 ASP B CB  1 
ATOM   2948 C  CG  . ASP B 1 162 ? 32.61007  18.05066  18.69819 1.000 61.64120  ? 162 ASP B CG  1 
ATOM   2949 O  OD1 . ASP B 1 162 ? 33.18861  19.12821  18.44676 1.000 66.67666  ? 162 ASP B OD1 1 
ATOM   2950 O  OD2 . ASP B 1 162 ? 31.36605  17.96272  18.78132 1.000 61.51450  ? 162 ASP B OD2 1 
ATOM   2951 N  N   . PHE B 1 163 ? 34.60300  13.94201  17.97249 1.000 53.92704  ? 163 PHE B N   1 
ATOM   2952 C  CA  . PHE B 1 163 ? 35.40927  12.76765  18.26889 1.000 50.25810  ? 163 PHE B CA  1 
ATOM   2953 C  C   . PHE B 1 163 ? 34.80006  11.58532  17.53524 1.000 49.75525  ? 163 PHE B C   1 
ATOM   2954 O  O   . PHE B 1 163 ? 33.58114  11.53123  17.33594 1.000 44.77166  ? 163 PHE B O   1 
ATOM   2955 C  CB  . PHE B 1 163 ? 35.45770  12.45212  19.77128 1.000 48.84158  ? 163 PHE B CB  1 
ATOM   2956 C  CG  . PHE B 1 163 ? 36.01956  13.56485  20.62016 1.000 54.74556  ? 163 PHE B CG  1 
ATOM   2957 C  CD1 . PHE B 1 163 ? 37.38330  13.79950  20.65573 1.000 56.46912  ? 163 PHE B CD1 1 
ATOM   2958 C  CD2 . PHE B 1 163 ? 35.18527  14.35303  21.40569 1.000 55.79643  ? 163 PHE B CD2 1 
ATOM   2959 C  CE1 . PHE B 1 163 ? 37.90670  14.81504  21.43397 1.000 65.38817  ? 163 PHE B CE1 1 
ATOM   2960 C  CE2 . PHE B 1 163 ? 35.70328  15.36217  22.20443 1.000 54.01652  ? 163 PHE B CE2 1 
ATOM   2961 C  CZ  . PHE B 1 163 ? 37.06278  15.59679  22.21715 1.000 65.39537  ? 163 PHE B CZ  1 
ATOM   2962 N  N   . GLY B 1 164 ? 35.65096  10.62871  17.13755 1.000 43.48000  ? 164 GLY B N   1 
ATOM   2963 C  CA  . GLY B 1 164 ? 35.17194  9.44013   16.46678 1.000 43.87012  ? 164 GLY B CA  1 
ATOM   2964 C  C   . GLY B 1 164 ? 35.76890  8.20404   17.11527 1.000 51.44350  ? 164 GLY B C   1 
ATOM   2965 O  O   . GLY B 1 164 ? 36.68454  8.31549   17.93495 1.000 46.31360  ? 164 GLY B O   1 
ATOM   2966 N  N   . VAL B 1 165 ? 35.23810  7.02766   16.76880 1.000 53.97797  ? 165 VAL B N   1 
ATOM   2967 C  CA  . VAL B 1 165 ? 35.87232  5.77584   17.16249 1.000 44.56033  ? 165 VAL B CA  1 
ATOM   2968 C  C   . VAL B 1 165 ? 35.55995  4.74086   16.10448 1.000 42.69864  ? 165 VAL B C   1 
ATOM   2969 O  O   . VAL B 1 165 ? 34.43616  4.68297   15.59372 1.000 52.57546  ? 165 VAL B O   1 
ATOM   2970 C  CB  . VAL B 1 165 ? 35.43386  5.28558   18.55601 1.000 39.08505  ? 165 VAL B CB  1 
ATOM   2971 C  CG1 . VAL B 1 165 ? 33.92871  5.04299   18.62939 1.000 43.76405  ? 165 VAL B CG1 1 
ATOM   2972 C  CG2 . VAL B 1 165 ? 36.21060  4.03066   18.87748 1.000 35.33801  ? 165 VAL B CG2 1 
ATOM   2973 N  N   . ILE B 1 166 ? 36.56968  3.93731   15.75756 1.000 35.69728  ? 166 ILE B N   1 
ATOM   2974 C  CA  . ILE B 1 166 ? 36.39207  2.79481   14.87169 1.000 43.13622  ? 166 ILE B CA  1 
ATOM   2975 C  C   . ILE B 1 166 ? 36.89954  1.53611   15.56712 1.000 35.41707  ? 166 ILE B C   1 
ATOM   2976 O  O   . ILE B 1 166 ? 37.99001  1.53584   16.14221 1.000 49.51821  ? 166 ILE B O   1 
ATOM   2977 C  CB  . ILE B 1 166 ? 37.10920  3.01819   13.51255 1.000 47.01964  ? 166 ILE B CB  1 
ATOM   2978 C  CG1 . ILE B 1 166 ? 36.87604  1.84007   12.56553 1.000 48.18914  ? 166 ILE B CG1 1 
ATOM   2979 C  CG2 . ILE B 1 166 ? 38.61361  3.27668   13.69142 1.000 42.43020  ? 166 ILE B CG2 1 
ATOM   2980 C  CD1 . ILE B 1 166 ? 37.59687  1.99296   11.22690 1.000 60.06575  ? 166 ILE B CD1 1 
ATOM   2981 N  N   . HIS B 1 167 ? 36.11775  0.45764   15.48652 1.000 39.61772  ? 167 HIS B N   1 
ATOM   2982 C  CA  . HIS B 1 167 ? 36.50345  -0.86750  15.97092 1.000 53.20917  ? 167 HIS B CA  1 
ATOM   2983 C  C   . HIS B 1 167 ? 36.48105  -1.81594  14.78506 1.000 54.99868  ? 167 HIS B C   1 
ATOM   2984 O  O   . HIS B 1 167 ? 35.44683  -1.93792  14.11944 1.000 57.67467  ? 167 HIS B O   1 
ATOM   2985 C  CB  . HIS B 1 167 ? 35.54561  -1.39511  17.05058 1.000 47.06155  ? 167 HIS B CB  1 
ATOM   2986 C  CG  . HIS B 1 167 ? 35.36958  -0.47525  18.21466 1.000 51.72238  ? 167 HIS B CG  1 
ATOM   2987 N  ND1 . HIS B 1 167 ? 36.33946  -0.30779  19.17731 1.000 52.33079  ? 167 HIS B ND1 1 
ATOM   2988 C  CD2 . HIS B 1 167 ? 34.33673  0.32437   18.57454 1.000 45.24982  ? 167 HIS B CD2 1 
ATOM   2989 C  CE1 . HIS B 1 167 ? 35.91335  0.55985   20.07814 1.000 48.97364  ? 167 HIS B CE1 1 
ATOM   2990 N  NE2 . HIS B 1 167 ? 34.70370  0.95981   19.73445 1.000 44.45652  ? 167 HIS B NE2 1 
ATOM   2991 N  N   . LEU B 1 168 ? 37.61014  -2.47614  14.51399 1.000 57.64163  ? 168 LEU B N   1 
ATOM   2992 C  CA  . LEU B 1 168 ? 37.66826  -3.47280  13.44463 1.000 48.41805  ? 168 LEU B CA  1 
ATOM   2993 C  C   . LEU B 1 168 ? 36.91627  -4.71290  13.90657 1.000 57.44824  ? 168 LEU B C   1 
ATOM   2994 O  O   . LEU B 1 168 ? 37.32216  -5.37189  14.87092 1.000 51.63257  ? 168 LEU B O   1 
ATOM   2995 C  CB  . LEU B 1 168 ? 39.11988  -3.79596  13.09162 1.000 61.26255  ? 168 LEU B CB  1 
ATOM   2996 C  CG  . LEU B 1 168 ? 39.46886  -4.60603  11.82354 1.000 66.91128  ? 168 LEU B CG  1 
ATOM   2997 C  CD1 . LEU B 1 168 ? 39.19141  -6.10928  11.95431 1.000 52.30696  ? 168 LEU B CD1 1 
ATOM   2998 C  CD2 . LEU B 1 168 ? 38.76111  -4.03116  10.59884 1.000 57.26284  ? 168 LEU B CD2 1 
ATOM   2999 N  N   . MET B 1 169 ? 35.80275  -5.01836  13.24079 1.000 54.65397  ? 169 MET B N   1 
ATOM   3000 C  CA  . MET B 1 169 ? 35.01005  -6.18247  13.60709 1.000 53.61808  ? 169 MET B CA  1 
ATOM   3001 C  C   . MET B 1 169 ? 35.46107  -7.44192  12.89767 1.000 67.89163  ? 169 MET B C   1 
ATOM   3002 O  O   . MET B 1 169 ? 35.26569  -8.53904  13.42706 1.000 69.07903  ? 169 MET B O   1 
ATOM   3003 C  CB  . MET B 1 169 ? 33.52815  -5.94375  13.30339 1.000 56.11868  ? 169 MET B CB  1 
ATOM   3004 C  CG  . MET B 1 169 ? 32.93936  -4.81629  14.09817 1.000 58.03293  ? 169 MET B CG  1 
ATOM   3005 S  SD  . MET B 1 169 ? 33.07144  -5.07938  15.89284 1.000 61.00359  ? 169 MET B SD  1 
ATOM   3006 C  CE  . MET B 1 169 ? 31.80209  -6.29785  16.10959 1.000 43.27691  ? 169 MET B CE  1 
ATOM   3007 N  N   . GLY B 1 170 ? 36.04836  -7.31246  11.71230 1.000 75.02316  ? 170 GLY B N   1 
ATOM   3008 C  CA  . GLY B 1 170 ? 36.48774  -8.47004  10.96125 1.000 61.53022  ? 170 GLY B CA  1 
ATOM   3009 C  C   . GLY B 1 170 ? 37.23378  -8.05621  9.72032  1.000 66.55884  ? 170 GLY B C   1 
ATOM   3010 O  O   . GLY B 1 170 ? 37.05669  -6.95175  9.19784  1.000 72.46397  ? 170 GLY B O   1 
ATOM   3011 N  N   . ARG B 1 171 ? 38.07251  -8.96748  9.25691  1.000 74.17119  ? 171 ARG B N   1 
ATOM   3012 C  CA  . ARG B 1 171 ? 38.85397  -8.75832  8.05113  1.000 79.59792  ? 171 ARG B CA  1 
ATOM   3013 C  C   . ARG B 1 171 ? 38.99275  -10.12006 7.39725  1.000 76.70897  ? 171 ARG B C   1 
ATOM   3014 O  O   . ARG B 1 171 ? 39.33742  -11.08822 8.07794  1.000 78.02173  ? 171 ARG B O   1 
ATOM   3015 C  CB  . ARG B 1 171 ? 40.22091  -8.14058  8.38502  1.000 84.08372  ? 171 ARG B CB  1 
ATOM   3016 C  CG  . ARG B 1 171 ? 40.74760  -7.13999  7.37107  1.000 81.39158  ? 171 ARG B CG  1 
ATOM   3017 C  CD  . ARG B 1 171 ? 41.99063  -6.43478  7.88010  1.000 77.12069  ? 171 ARG B CD  1 
ATOM   3018 N  NE  . ARG B 1 171 ? 42.64175  -5.66067  6.83058  1.000 82.17493  ? 171 ARG B NE  1 
ATOM   3019 C  CZ  . ARG B 1 171 ? 43.64566  -6.11252  6.09099  1.000 89.91502  ? 171 ARG B CZ  1 
ATOM   3020 N  NH1 . ARG B 1 171 ? 44.15687  -7.32043  6.28326  1.000 87.51686  ? 171 ARG B NH1 1 
ATOM   3021 N  NH2 . ARG B 1 171 ? 44.15049  -5.33478  5.13517  1.000 84.48750  ? 171 ARG B NH2 1 
ATOM   3022 N  N   . PHE B 1 172 ? 38.67962  -10.20912 6.10557  1.000 80.99390  ? 172 PHE B N   1 
ATOM   3023 C  CA  . PHE B 1 172 ? 38.69235  -11.49448 5.40569  1.000 87.20753  ? 172 PHE B CA  1 
ATOM   3024 C  C   . PHE B 1 172 ? 39.28861  -11.29980 4.02209  1.000 74.25622  ? 172 PHE B C   1 
ATOM   3025 O  O   . PHE B 1 172 ? 38.71263  -10.58039 3.20298  1.000 76.04381  ? 172 PHE B O   1 
ATOM   3026 C  CB  . PHE B 1 172 ? 37.28616  -12.08756 5.30762  1.000 85.71840  ? 172 PHE B CB  1 
ATOM   3027 C  CG  . PHE B 1 172 ? 36.47161  -11.91455 6.55435  1.000 87.76245  ? 172 PHE B CG  1 
ATOM   3028 C  CD1 . PHE B 1 172 ? 36.76975  -12.63883 7.69646  1.000 84.90652  ? 172 PHE B CD1 1 
ATOM   3029 C  CD2 . PHE B 1 172 ? 35.41042  -11.01374 6.58775  1.000 88.73992  ? 172 PHE B CD2 1 
ATOM   3030 C  CE1 . PHE B 1 172 ? 36.02266  -12.47348 8.85227  1.000 85.16504  ? 172 PHE B CE1 1 
ATOM   3031 C  CE2 . PHE B 1 172 ? 34.65731  -10.84447 7.73751  1.000 75.66460  ? 172 PHE B CE2 1 
ATOM   3032 C  CZ  . PHE B 1 172 ? 34.96257  -11.57261 8.87107  1.000 78.47645  ? 172 PHE B CZ  1 
ATOM   3033 N  N   . ASN B 1 173 ? 40.44092  -11.92829 3.77800  1.000 75.43672  ? 173 ASN B N   1 
ATOM   3034 C  CA  . ASN B 1 173 ? 41.07040  -11.95447 2.45863  1.000 65.83597  ? 173 ASN B CA  1 
ATOM   3035 C  C   . ASN B 1 173 ? 41.30281  -10.53930 1.92481  1.000 74.34702  ? 173 ASN B C   1 
ATOM   3036 O  O   . ASN B 1 173 ? 40.96855  -10.21190 0.78378  1.000 80.52275  ? 173 ASN B O   1 
ATOM   3037 C  CB  . ASN B 1 173 ? 40.22772  -12.78354 1.48278  1.000 74.15314  ? 173 ASN B CB  1 
ATOM   3038 C  CG  . ASN B 1 173 ? 40.98143  -13.15267 0.21667  1.000 84.67017  ? 173 ASN B CG  1 
ATOM   3039 O  OD1 . ASN B 1 173 ? 42.16708  -13.49007 0.25965  1.000 88.09708  ? 173 ASN B OD1 1 
ATOM   3040 N  ND2 . ASN B 1 173 ? 40.29727  -13.07652 -0.92159 1.000 83.16912  ? 173 ASN B ND2 1 
ATOM   3041 N  N   . ALA B 1 174 ? 41.87965  -9.68757  2.76414  1.000 80.25841  ? 174 ALA B N   1 
ATOM   3042 C  CA  . ALA B 1 174 ? 42.03091  -8.27833  2.43465  1.000 80.30876  ? 174 ALA B CA  1 
ATOM   3043 C  C   . ALA B 1 174 ? 43.46854  -7.84385  2.67082  1.000 88.45497  ? 174 ALA B C   1 
ATOM   3044 O  O   . ALA B 1 174 ? 44.02154  -8.06687  3.75269  1.000 87.10451  ? 174 ALA B O   1 
ATOM   3045 C  CB  . ALA B 1 174 ? 41.06973  -7.40919  3.25599  1.000 76.06936  ? 174 ALA B CB  1 
ATOM   3046 N  N   . ALA B 1 175 ? 44.06903  -7.23558  1.65464  1.000 84.99264  ? 175 ALA B N   1 
ATOM   3047 C  CA  . ALA B 1 175 ? 45.29896  -6.47610  1.79284  1.000 83.91850  ? 175 ALA B CA  1 
ATOM   3048 C  C   . ALA B 1 175 ? 44.98300  -4.99345  1.62146  1.000 77.03139  ? 175 ALA B C   1 
ATOM   3049 O  O   . ALA B 1 175 ? 43.89974  -4.61714  1.16030  1.000 79.26376  ? 175 ALA B O   1 
ATOM   3050 C  CB  . ALA B 1 175 ? 46.34288  -6.93460  0.76564  1.000 94.87162  ? 175 ALA B CB  1 
ATOM   3051 N  N   . GLY B 1 176 ? 45.94676  -4.14732  1.98572  1.000 75.05923  ? 176 GLY B N   1 
ATOM   3052 C  CA  . GLY B 1 176 ? 45.69954  -2.71463  1.98786  1.000 81.75418  ? 176 GLY B CA  1 
ATOM   3053 C  C   . GLY B 1 176 ? 44.70707  -2.35882  3.08099  1.000 74.79711  ? 176 GLY B C   1 
ATOM   3054 O  O   . GLY B 1 176 ? 44.60136  -3.04506  4.09074  1.000 73.45821  ? 176 GLY B O   1 
ATOM   3055 N  N   . GLY B 1 177 ? 43.94692  -1.29455  2.86087  1.000 75.68623  ? 177 GLY B N   1 
ATOM   3056 C  CA  . GLY B 1 177 ? 43.03008  -0.86822  3.90305  1.000 72.50947  ? 177 GLY B CA  1 
ATOM   3057 C  C   . GLY B 1 177 ? 43.70879  -0.28503  5.11712  1.000 68.25443  ? 177 GLY B C   1 
ATOM   3058 O  O   . GLY B 1 177 ? 43.24652  -0.49816  6.23841  1.000 74.46492  ? 177 GLY B O   1 
ATOM   3059 N  N   . GLU B 1 178 ? 44.79351  0.45199   4.91957  1.000 68.69408  ? 178 GLU B N   1 
ATOM   3060 C  CA  . GLU B 1 178 ? 45.46634  1.11288   6.02093  1.000 67.83762  ? 178 GLU B CA  1 
ATOM   3061 C  C   . GLU B 1 178 ? 44.63102  2.28997   6.49286  1.000 71.52469  ? 178 GLU B C   1 
ATOM   3062 O  O   . GLU B 1 178 ? 43.90948  2.91425   5.71190  1.000 77.90548  ? 178 GLU B O   1 
ATOM   3063 C  CB  . GLU B 1 178 ? 46.85147  1.59373   5.58944  1.000 70.78435  ? 178 GLU B CB  1 
ATOM   3064 C  CG  . GLU B 1 178 ? 47.82040  0.48892   5.23142  1.000 73.52958  ? 178 GLU B CG  1 
ATOM   3065 C  CD  . GLU B 1 178 ? 48.28512  0.58934   3.78653  1.000 85.57356  ? 178 GLU B CD  1 
ATOM   3066 O  OE1 . GLU B 1 178 ? 47.49559  0.24432   2.87852  1.000 83.62336  ? 178 GLU B OE1 1 
ATOM   3067 O  OE2 . GLU B 1 178 ? 49.45156  1.00837   3.57736  1.000 86.09101  ? 178 GLU B OE2 1 
ATOM   3068 N  N   . SER B 1 179 ? 44.71249  2.57197   7.78189  1.000 58.96598  ? 179 SER B N   1 
ATOM   3069 C  CA  . SER B 1 179 ? 44.15236  3.78575   8.33843  1.000 61.58196  ? 179 SER B CA  1 
ATOM   3070 C  C   . SER B 1 179 ? 45.23530  4.85628   8.31771  1.000 62.36040  ? 179 SER B C   1 
ATOM   3071 O  O   . SER B 1 179 ? 46.39855  4.58338   8.63949  1.000 64.67402  ? 179 SER B O   1 
ATOM   3072 C  CB  . SER B 1 179 ? 43.64168  3.52459   9.75439  1.000 59.11195  ? 179 SER B CB  1 
ATOM   3073 O  OG  . SER B 1 179 ? 42.87283  2.32603   9.78780  1.000 58.57587  ? 179 SER B OG  1 
ATOM   3074 N  N   . GLN B 1 180 ? 44.86059  6.06330   7.91572  1.000 53.75685  ? 180 GLN B N   1 
ATOM   3075 C  CA  . GLN B 1 180 ? 45.81659  7.13012   7.68301  1.000 60.47764  ? 180 GLN B CA  1 
ATOM   3076 C  C   . GLN B 1 180 ? 45.41729  8.34477   8.49095  1.000 60.91664  ? 180 GLN B C   1 
ATOM   3077 O  O   . GLN B 1 180 ? 44.25198  8.76060   8.46139  1.000 55.17864  ? 180 GLN B O   1 
ATOM   3078 C  CB  . GLN B 1 180 ? 45.88456  7.50502   6.19820  1.000 63.42878  ? 180 GLN B CB  1 
ATOM   3079 C  CG  . GLN B 1 180 ? 46.19209  6.34265   5.26938  1.000 65.85192  ? 180 GLN B CG  1 
ATOM   3080 C  CD  . GLN B 1 180 ? 46.46694  6.79204   3.84672  1.000 72.42912  ? 180 GLN B CD  1 
ATOM   3081 O  OE1 . GLN B 1 180 ? 45.85745  7.74694   3.34733  1.000 71.33815  ? 180 GLN B OE1 1 
ATOM   3082 N  NE2 . GLN B 1 180 ? 47.40619  6.11775   3.19224  1.000 58.78733  ? 180 GLN B NE2 1 
ATOM   3083 N  N   . VAL B 1 181 ? 46.38617  8.92272   9.18888  1.000 60.31943  ? 181 VAL B N   1 
ATOM   3084 C  CA  . VAL B 1 181 ? 46.20764  10.20452  9.85142  1.000 69.80910  ? 181 VAL B CA  1 
ATOM   3085 C  C   . VAL B 1 181 ? 46.96299  11.25666  9.05244  1.000 68.75104  ? 181 VAL B C   1 
ATOM   3086 O  O   . VAL B 1 181 ? 48.13477  11.06212  8.70486  1.000 70.76051  ? 181 VAL B O   1 
ATOM   3087 C  CB  . VAL B 1 181 ? 46.67980  10.16225  11.31451 1.000 68.19223  ? 181 VAL B CB  1 
ATOM   3088 C  CG1 . VAL B 1 181 ? 46.42281  11.50384  11.97804 1.000 62.77502  ? 181 VAL B CG1 1 
ATOM   3089 C  CG2 . VAL B 1 181 ? 45.96886  9.04683   12.06949 1.000 55.61127  ? 181 VAL B CG2 1 
ATOM   3090 N  N   . TYR B 1 182 ? 46.28109  12.35671  8.74347  1.000 72.83410  ? 182 TYR B N   1 
ATOM   3091 C  CA  . TYR B 1 182 ? 46.86004  13.50506  8.06379  1.000 77.67755  ? 182 TYR B CA  1 
ATOM   3092 C  C   . TYR B 1 182 ? 46.81890  14.71933  8.97821  1.000 76.48262  ? 182 TYR B C   1 
ATOM   3093 O  O   . TYR B 1 182 ? 46.11765  14.73566  9.99215  1.000 81.86211  ? 182 TYR B O   1 
ATOM   3094 C  CB  . TYR B 1 182 ? 46.10678  13.83571  6.77076  1.000 79.39876  ? 182 TYR B CB  1 
ATOM   3095 C  CG  . TYR B 1 182 ? 46.22099  12.78783  5.69224  1.000 75.86577  ? 182 TYR B CG  1 
ATOM   3096 C  CD1 . TYR B 1 182 ? 45.44406  11.64083  5.73296  1.000 71.08305  ? 182 TYR B CD1 1 
ATOM   3097 C  CD2 . TYR B 1 182 ? 47.09435  12.95398  4.62063  1.000 80.84873  ? 182 TYR B CD2 1 
ATOM   3098 C  CE1 . TYR B 1 182 ? 45.53752  10.68282  4.74366  1.000 80.90943  ? 182 TYR B CE1 1 
ATOM   3099 C  CE2 . TYR B 1 182 ? 47.19391  11.99578  3.62073  1.000 72.27772  ? 182 TYR B CE2 1 
ATOM   3100 C  CZ  . TYR B 1 182 ? 46.41038  10.86648  3.69583  1.000 71.47472  ? 182 TYR B CZ  1 
ATOM   3101 O  OH  . TYR B 1 182 ? 46.47812  9.89777   2.74013  1.000 63.83809  ? 182 TYR B OH  1 
ATOM   3102 N  N   . SER B 1 183 ? 47.56909  15.74605  8.60305  1.000 65.26796  ? 183 SER B N   1 
ATOM   3103 C  CA  . SER B 1 183 ? 47.48647  17.02259  9.28493  1.000 68.76467  ? 183 SER B CA  1 
ATOM   3104 C  C   . SER B 1 183 ? 46.39784  17.85764  8.63089  1.000 74.32044  ? 183 SER B C   1 
ATOM   3105 O  O   . SER B 1 183 ? 45.80641  17.47267  7.61908  1.000 78.37489  ? 183 SER B O   1 
ATOM   3106 C  CB  . SER B 1 183 ? 48.82537  17.75322  9.24506  1.000 85.23897  ? 183 SER B CB  1 
ATOM   3107 O  OG  . SER B 1 183 ? 49.10973  18.21568  7.93175  1.000 92.58558  ? 183 SER B OG  1 
ATOM   3108 N  N   . LEU B 1 184 ? 46.12304  19.02439  9.20775  1.000 76.40601  ? 184 LEU B N   1 
ATOM   3109 C  CA  . LEU B 1 184 ? 45.22251  19.94168  8.52272  1.000 84.41696  ? 184 LEU B CA  1 
ATOM   3110 C  C   . LEU B 1 184 ? 45.84766  20.50662  7.25747  1.000 84.39340  ? 184 LEU B C   1 
ATOM   3111 O  O   . LEU B 1 184 ? 45.14185  21.12393  6.45492  1.000 81.61317  ? 184 LEU B O   1 
ATOM   3112 C  CB  . LEU B 1 184 ? 44.80169  21.08090  9.45725  1.000 83.89209  ? 184 LEU B CB  1 
ATOM   3113 C  CG  . LEU B 1 184 ? 44.06596  20.61759  10.71711 1.000 90.06927  ? 184 LEU B CG  1 
ATOM   3114 C  CD1 . LEU B 1 184 ? 43.55843  21.79968  11.54207 1.000 86.08882  ? 184 LEU B CD1 1 
ATOM   3115 C  CD2 . LEU B 1 184 ? 42.92582  19.69098  10.33451 1.000 82.53297  ? 184 LEU B CD2 1 
ATOM   3116 N  N   . GLU B 1 185 ? 47.14693  20.29639  7.06307  1.000 88.61718  ? 185 GLU B N   1 
ATOM   3117 C  CA  . GLU B 1 185 ? 47.86076  20.68887  5.85803  1.000 90.00060  ? 185 GLU B CA  1 
ATOM   3118 C  C   . GLU B 1 185 ? 47.78332  19.62992  4.76459  1.000 89.79346  ? 185 GLU B C   1 
ATOM   3119 O  O   . GLU B 1 185 ? 48.51713  19.72627  3.77545  1.000 98.01791  ? 185 GLU B O   1 
ATOM   3120 C  CB  . GLU B 1 185 ? 49.32531  20.98423  6.19684  1.000 85.87836  ? 185 GLU B CB  1 
ATOM   3121 C  CG  . GLU B 1 185 ? 49.56907  21.32181  7.67735  1.000 87.58768  ? 185 GLU B CG  1 
ATOM   3122 C  CD  . GLU B 1 185 ? 48.90182  22.62162  8.12376  1.000 90.28037  ? 185 GLU B CD  1 
ATOM   3123 O  OE1 . GLU B 1 185 ? 49.04303  23.64440  7.41725  1.000 100.42758 ? 185 GLU B OE1 1 
ATOM   3124 O  OE2 . GLU B 1 185 ? 48.23057  22.61715  9.17947  1.000 84.30749  ? 185 GLU B OE2 1 
ATOM   3125 N  N   . ARG B 1 186 ? 46.91146  18.62949  4.92662  1.000 80.96953  ? 186 ARG B N   1 
ATOM   3126 C  CA  . ARG B 1 186 ? 46.78265  17.49438  4.00672  1.000 80.96385  ? 186 ARG B CA  1 
ATOM   3127 C  C   . ARG B 1 186 ? 48.09745  16.72239  3.84643  1.000 79.92757  ? 186 ARG B C   1 
ATOM   3128 O  O   . ARG B 1 186 ? 48.34731  16.11278  2.80404  1.000 79.31925  ? 186 ARG B O   1 
ATOM   3129 C  CB  . ARG B 1 186 ? 46.23819  17.94114  2.64460  1.000 74.47171  ? 186 ARG B CB  1 
ATOM   3130 C  CG  . ARG B 1 186 ? 44.82489  18.50426  2.70944  1.000 79.40352  ? 186 ARG B CG  1 
ATOM   3131 C  CD  . ARG B 1 186 ? 44.35906  18.97929  1.34232  1.000 96.16497  ? 186 ARG B CD  1 
ATOM   3132 N  NE  . ARG B 1 186 ? 43.04635  19.61617  1.38513  1.000 96.22363  ? 186 ARG B NE  1 
ATOM   3133 C  CZ  . ARG B 1 186 ? 42.42201  20.12573  0.32945  1.000 102.51418 ? 186 ARG B CZ  1 
ATOM   3134 N  NH1 . ARG B 1 186 ? 42.96163  20.08964  -0.87897 1.000 104.11305 ? 186 ARG B NH1 1 
ATOM   3135 N  NH2 . ARG B 1 186 ? 41.22338  20.68231  0.48865  1.000 95.71671  ? 186 ARG B NH2 1 
ATOM   3136 N  N   . GLU B 1 187 ? 48.93532  16.70857  4.88516  1.000 85.19292  ? 187 GLU B N   1 
ATOM   3137 C  CA  . GLU B 1 187 ? 50.21648  16.00507  4.87430  1.000 84.48435  ? 187 GLU B CA  1 
ATOM   3138 C  C   . GLU B 1 187 ? 50.11340  14.76724  5.75706  1.000 81.47251  ? 187 GLU B C   1 
ATOM   3139 O  O   . GLU B 1 187 ? 49.74155  14.87675  6.92774  1.000 87.06891  ? 187 GLU B O   1 
ATOM   3140 C  CB  . GLU B 1 187 ? 51.33643  16.93033  5.35605  1.000 87.97338  ? 187 GLU B CB  1 
ATOM   3141 C  CG  . GLU B 1 187 ? 52.72798  16.29559  5.42865  1.000 88.38814  ? 187 GLU B CG  1 
ATOM   3142 C  CD  . GLU B 1 187 ? 53.25731  16.18938  6.86286  1.000 96.29800  ? 187 GLU B CD  1 
ATOM   3143 O  OE1 . GLU B 1 187 ? 52.47870  16.45571  7.80460  1.000 94.47334  ? 187 GLU B OE1 1 
ATOM   3144 O  OE2 . GLU B 1 187 ? 54.44721  15.84236  7.05551  1.000 91.76712  ? 187 GLU B OE2 1 
ATOM   3145 N  N   . LEU B 1 188 ? 50.43204  13.59549  5.19914  1.000 71.84511  ? 188 LEU B N   1 
ATOM   3146 C  CA  . LEU B 1 188 ? 50.32452  12.34751  5.95377  1.000 71.08276  ? 188 LEU B CA  1 
ATOM   3147 C  C   . LEU B 1 188 ? 51.32261  12.34576  7.10727  1.000 81.12561  ? 188 LEU B C   1 
ATOM   3148 O  O   . LEU B 1 188 ? 52.53101  12.48488  6.89345  1.000 85.86277  ? 188 LEU B O   1 
ATOM   3149 C  CB  . LEU B 1 188 ? 50.55970  11.14511  5.03965  1.000 63.25775  ? 188 LEU B CB  1 
ATOM   3150 C  CG  . LEU B 1 188 ? 50.37208  9.69688   5.52542  1.000 71.10612  ? 188 LEU B CG  1 
ATOM   3151 C  CD1 . LEU B 1 188 ? 50.36732  8.75838   4.33463  1.000 62.48604  ? 188 LEU B CD1 1 
ATOM   3152 C  CD2 . LEU B 1 188 ? 51.43417  9.23053   6.51786  1.000 72.32452  ? 188 LEU B CD2 1 
ATOM   3153 N  N   . VAL B 1 189 ? 50.82081  12.17007  8.32828  1.000 86.98331  ? 189 VAL B N   1 
ATOM   3154 C  CA  . VAL B 1 189 ? 51.67203  12.13021  9.50991  1.000 84.57638  ? 189 VAL B CA  1 
ATOM   3155 C  C   . VAL B 1 189 ? 51.85926  10.71729  10.04645 1.000 81.33167  ? 189 VAL B C   1 
ATOM   3156 O  O   . VAL B 1 189 ? 52.78766  10.49132  10.83749 1.000 84.62566  ? 189 VAL B O   1 
ATOM   3157 C  CB  . VAL B 1 189 ? 51.13260  13.05213  10.62528 1.000 83.06493  ? 189 VAL B CB  1 
ATOM   3158 C  CG1 . VAL B 1 189 ? 50.72636  14.40827  10.06477 1.000 84.63961  ? 189 VAL B CG1 1 
ATOM   3159 C  CG2 . VAL B 1 189 ? 49.98186  12.38820  11.35931 1.000 83.77301  ? 189 VAL B CG2 1 
ATOM   3160 N  N   . ALA B 1 190 ? 51.02438  9.76638   9.64852  1.000 77.20745  ? 190 ALA B N   1 
ATOM   3161 C  CA  . ALA B 1 190 ? 51.08199  8.42312   10.20106 1.000 72.98331  ? 190 ALA B CA  1 
ATOM   3162 C  C   . ALA B 1 190 ? 50.22668  7.51337   9.34568  1.000 65.38262  ? 190 ALA B C   1 
ATOM   3163 O  O   . ALA B 1 190 ? 49.32358  7.96034   8.63417  1.000 68.28995  ? 190 ALA B O   1 
ATOM   3164 C  CB  . ALA B 1 190 ? 50.60044  8.37604   11.65444 1.000 60.53902  ? 190 ALA B CB  1 
ATOM   3165 N  N   . GLU B 1 191 ? 50.51495  6.22565   9.44225  1.000 56.95915  ? 191 GLU B N   1 
ATOM   3166 C  CA  . GLU B 1 191 ? 49.71249  5.23541   8.75226  1.000 69.98080  ? 191 GLU B CA  1 
ATOM   3167 C  C   . GLU B 1 191 ? 49.81790  3.93167   9.52013  1.000 66.98883  ? 191 GLU B C   1 
ATOM   3168 O  O   . GLU B 1 191 ? 50.89839  3.55681   9.97747  1.000 73.42319  ? 191 GLU B O   1 
ATOM   3169 C  CB  . GLU B 1 191 ? 50.16862  5.04624   7.30480  1.000 70.51292  ? 191 GLU B CB  1 
ATOM   3170 C  CG  . GLU B 1 191 ? 49.12537  4.42251   6.41244  1.000 72.76841  ? 191 GLU B CG  1 
ATOM   3171 C  CD  . GLU B 1 191 ? 49.64795  4.15889   5.01746  1.000 70.21237  ? 191 GLU B CD  1 
ATOM   3172 O  OE1 . GLU B 1 191 ? 50.48915  3.25265   4.86954  1.000 75.79187  ? 191 GLU B OE1 1 
ATOM   3173 O  OE2 . GLU B 1 191 ? 49.22834  4.86890   4.07903  1.000 63.77717  ? 191 GLU B OE2 1 
ATOM   3174 N  N   . PHE B 1 192 ? 48.68816  3.25802   9.67720  1.000 65.13469  ? 192 PHE B N   1 
ATOM   3175 C  CA  . PHE B 1 192 ? 48.65009  2.02180   10.43526 1.000 67.01405  ? 192 PHE B CA  1 
ATOM   3176 C  C   . PHE B 1 192 ? 47.51822  1.16626   9.89989  1.000 66.14054  ? 192 PHE B C   1 
ATOM   3177 O  O   . PHE B 1 192 ? 46.68756  1.61237   9.10459  1.000 66.27689  ? 192 PHE B O   1 
ATOM   3178 C  CB  . PHE B 1 192 ? 48.48005  2.27586   11.94015 1.000 62.77542  ? 192 PHE B CB  1 
ATOM   3179 C  CG  . PHE B 1 192 ? 47.43216  3.29593   12.27084 1.000 57.15919  ? 192 PHE B CG  1 
ATOM   3180 C  CD1 . PHE B 1 192 ? 47.77000  4.63185   12.39007 1.000 71.91641  ? 192 PHE B CD1 1 
ATOM   3181 C  CD2 . PHE B 1 192 ? 46.11142  2.92399   12.46124 1.000 68.91128  ? 192 PHE B CD2 1 
ATOM   3182 C  CE1 . PHE B 1 192 ? 46.81125  5.58293   12.68699 1.000 81.82920  ? 192 PHE B CE1 1 
ATOM   3183 C  CE2 . PHE B 1 192 ? 45.14106  3.87268   12.77122 1.000 72.99662  ? 192 PHE B CE2 1 
ATOM   3184 C  CZ  . PHE B 1 192 ? 45.49372  5.20114   12.88318 1.000 77.32750  ? 192 PHE B CZ  1 
ATOM   3185 N  N   . CYS B 1 193 ? 47.49149  -0.07373  10.36581 1.000 64.29590  ? 193 CYS B N   1 
ATOM   3186 C  CA  . CYS B 1 193 ? 46.59911  -1.09539  9.84513  1.000 70.58097  ? 193 CYS B CA  1 
ATOM   3187 C  C   . CYS B 1 193 ? 45.86011  -1.71878  11.01934 1.000 74.75883  ? 193 CYS B C   1 
ATOM   3188 O  O   . CYS B 1 193 ? 46.49017  -2.26940  11.92815 1.000 72.67456  ? 193 CYS B O   1 
ATOM   3189 C  CB  . CYS B 1 193 ? 47.39237  -2.15544  9.06777  1.000 68.89907  ? 193 CYS B CB  1 
ATOM   3190 S  SG  . CYS B 1 193 ? 46.62020  -2.71972  7.53930  1.000 87.08625  ? 193 CYS B SG  1 
ATOM   3191 N  N   . LEU B 1 194 ? 44.53494  -1.60269  11.02551 1.000 74.15498  ? 194 LEU B N   1 
ATOM   3192 C  CA  . LEU B 1 194 ? 43.73167  -2.39703  11.94333 1.000 71.01869  ? 194 LEU B CA  1 
ATOM   3193 C  C   . LEU B 1 194 ? 43.58759  -3.79522  11.36170 1.000 69.66223  ? 194 LEU B C   1 
ATOM   3194 O  O   . LEU B 1 194 ? 43.16102  -3.96320  10.21336 1.000 58.51251  ? 194 LEU B O   1 
ATOM   3195 C  CB  . LEU B 1 194 ? 42.35773  -1.76694  12.17746 1.000 60.22669  ? 194 LEU B CB  1 
ATOM   3196 C  CG  . LEU B 1 194 ? 42.25582  -0.37461  12.80706 1.000 67.38103  ? 194 LEU B CG  1 
ATOM   3197 C  CD1 . LEU B 1 194 ? 40.78488  -0.04036  13.04859 1.000 62.90258  ? 194 LEU B CD1 1 
ATOM   3198 C  CD2 . LEU B 1 194 ? 43.04423  -0.27065  14.09072 1.000 55.89607  ? 194 LEU B CD2 1 
ATOM   3199 N  N   . THR B 1 195 ? 43.95698  -4.77932  12.13570 1.000 65.20139  ? 195 THR B N   1 
ATOM   3200 C  CA  . THR B 1 195 ? 44.05464  -6.12906  11.59979 1.000 76.19452  ? 195 THR B CA  1 
ATOM   3201 C  C   . THR B 1 195 ? 43.27392  -7.15382  12.40355 1.000 68.18137  ? 195 THR B C   1 
ATOM   3202 O  O   . THR B 1 195 ? 42.72027  -8.08816  11.81894 1.000 74.96810  ? 195 THR B O   1 
ATOM   3203 C  CB  . THR B 1 195 ? 45.55381  -6.53882  11.51381 1.000 85.81068  ? 195 THR B CB  1 
ATOM   3204 O  OG1 . THR B 1 195 ? 46.27643  -6.03801  12.65329 1.000 70.91869  ? 195 THR B OG1 1 
ATOM   3205 C  CG2 . THR B 1 195 ? 46.18600  -5.98749  10.23532 1.000 82.85098  ? 195 THR B CG2 1 
ATOM   3206 N  N   . GLU B 1 196 ? 43.20093  -6.99792  13.71933 1.000 68.29522  ? 196 GLU B N   1 
ATOM   3207 C  CA  . GLU B 1 196 ? 42.52239  -7.96873  14.56292 1.000 74.76113  ? 196 GLU B CA  1 
ATOM   3208 C  C   . GLU B 1 196 ? 41.15837  -7.46045  15.02193 1.000 64.78255  ? 196 GLU B C   1 
ATOM   3209 O  O   . GLU B 1 196 ? 40.92594  -6.25450  15.14364 1.000 62.50500  ? 196 GLU B O   1 
ATOM   3210 C  CB  . GLU B 1 196 ? 43.38252  -8.32604  15.77431 1.000 65.78139  ? 196 GLU B CB  1 
ATOM   3211 C  CG  . GLU B 1 196 ? 44.46102  -9.33971  15.45690 1.000 72.06954  ? 196 GLU B CG  1 
ATOM   3212 C  CD  . GLU B 1 196 ? 45.14187  -9.86937  16.70104 1.000 87.50225  ? 196 GLU B CD  1 
ATOM   3213 O  OE1 . GLU B 1 196 ? 44.60944  -9.64245  17.81311 1.000 80.98420  ? 196 GLU B OE1 1 
ATOM   3214 O  OE2 . GLU B 1 196 ? 46.21306  -10.50567 16.57036 1.000 86.45107  ? 196 GLU B OE2 1 
ATOM   3215 N  N   . GLN B 1 197 ? 40.24723  -8.40301  15.25715 1.000 60.98777  ? 197 GLN B N   1 
ATOM   3216 C  CA  . GLN B 1 197 ? 38.93384  -8.04873  15.77464 1.000 67.69948  ? 197 GLN B CA  1 
ATOM   3217 C  C   . GLN B 1 197 ? 39.09554  -7.26583  17.06637 1.000 65.86795  ? 197 GLN B C   1 
ATOM   3218 O  O   . GLN B 1 197 ? 39.89341  -7.63147  17.92906 1.000 65.70107  ? 197 GLN B O   1 
ATOM   3219 C  CB  . GLN B 1 197 ? 38.08216  -9.29927  16.02026 1.000 54.38197  ? 197 GLN B CB  1 
ATOM   3220 C  CG  . GLN B 1 197 ? 36.72005  -9.00099  16.61855 1.000 55.82332  ? 197 GLN B CG  1 
ATOM   3221 C  CD  . GLN B 1 197 ? 35.84447  -10.23185 16.75205 1.000 55.14004  ? 197 GLN B CD  1 
ATOM   3222 O  OE1 . GLN B 1 197 ? 36.13191  -11.13616 17.53753 1.000 56.15746  ? 197 GLN B OE1 1 
ATOM   3223 N  NE2 . GLN B 1 197 ? 34.76081  -10.26743 15.99142 1.000 47.97139  ? 197 GLN B NE2 1 
ATOM   3224 N  N   . MET B 1 198 ? 38.35793  -6.16452  17.17245 1.000 64.09542  ? 198 MET B N   1 
ATOM   3225 C  CA  . MET B 1 198 ? 38.30752  -5.24364  18.30347 1.000 58.39426  ? 198 MET B CA  1 
ATOM   3226 C  C   . MET B 1 198 ? 39.48931  -4.28766  18.33010 1.000 58.78389  ? 198 MET B C   1 
ATOM   3227 O  O   . MET B 1 198 ? 39.53462  -3.42899  19.22098 1.000 59.24565  ? 198 MET B O   1 
ATOM   3228 C  CB  . MET B 1 198 ? 38.22264  -5.95834  19.65745 1.000 58.95746  ? 198 MET B CB  1 
ATOM   3229 C  CG  . MET B 1 198 ? 37.17796  -5.36599  20.52920 1.000 58.62930  ? 198 MET B CG  1 
ATOM   3230 S  SD  . MET B 1 198 ? 35.60468  -5.27839  19.66508 1.000 56.31169  ? 198 MET B SD  1 
ATOM   3231 C  CE  . MET B 1 198 ? 34.90879  -3.96988  20.65238 1.000 52.76035  ? 198 MET B CE  1 
ATOM   3232 N  N   . ASP B 1 199 ? 40.44477  -4.40576  17.40768 1.000 56.45820  ? 199 ASP B N   1 
ATOM   3233 C  CA  . ASP B 1 199 ? 41.37200  -3.31101  17.16188 1.000 60.37554  ? 199 ASP B CA  1 
ATOM   3234 C  C   . ASP B 1 199 ? 40.58785  -2.01312  17.02253 1.000 46.76474  ? 199 ASP B C   1 
ATOM   3235 O  O   . ASP B 1 199 ? 39.54698  -1.96919  16.36273 1.000 54.76462  ? 199 ASP B O   1 
ATOM   3236 C  CB  . ASP B 1 199 ? 42.20083  -3.57195  15.89737 1.000 65.34726  ? 199 ASP B CB  1 
ATOM   3237 C  CG  . ASP B 1 199 ? 43.27224  -4.63584  16.10716 1.000 65.16063  ? 199 ASP B CG  1 
ATOM   3238 O  OD1 . ASP B 1 199 ? 43.44255  -5.08105  17.25870 1.000 59.05225  ? 199 ASP B OD1 1 
ATOM   3239 O  OD2 . ASP B 1 199 ? 43.93959  -5.02819  15.12480 1.000 69.06371  ? 199 ASP B OD2 1 
ATOM   3240 N  N   . THR B 1 200 ? 41.08470  -0.95554  17.66091 1.000 46.38761  ? 200 THR B N   1 
ATOM   3241 C  CA  . THR B 1 200 ? 40.31003  0.25756   17.86952 1.000 44.44241  ? 200 THR B CA  1 
ATOM   3242 C  C   . THR B 1 200 ? 41.21473  1.45697   17.66132 1.000 47.19630  ? 200 THR B C   1 
ATOM   3243 O  O   . THR B 1 200 ? 42.40642  1.39740   17.95827 1.000 51.12550  ? 200 THR B O   1 
ATOM   3244 C  CB  . THR B 1 200 ? 39.69732  0.28908   19.30123 1.000 52.01482  ? 200 THR B CB  1 
ATOM   3245 O  OG1 . THR B 1 200 ? 38.75788  -0.78501  19.47876 1.000 49.69776  ? 200 THR B OG1 1 
ATOM   3246 C  CG2 . THR B 1 200 ? 39.02095  1.61092   19.57676 1.000 34.58356  ? 200 THR B CG2 1 
ATOM   3247 N  N   . MET B 1 201 ? 40.64624  2.55100   17.16401 1.000 49.39843  ? 201 MET B N   1 
ATOM   3248 C  CA  . MET B 1 201 ? 41.40985  3.77222   16.95311 1.000 54.84497  ? 201 MET B CA  1 
ATOM   3249 C  C   . MET B 1 201 ? 40.58546  4.95251   17.44762 1.000 48.59815  ? 201 MET B C   1 
ATOM   3250 O  O   . MET B 1 201 ? 39.42401  5.12009   17.02814 1.000 48.55204  ? 201 MET B O   1 
ATOM   3251 C  CB  . MET B 1 201 ? 41.77273  3.98324   15.48696 1.000 48.91488  ? 201 MET B CB  1 
ATOM   3252 C  CG  . MET B 1 201 ? 42.21139  5.41444   15.19535 1.000 52.38764  ? 201 MET B CG  1 
ATOM   3253 S  SD  . MET B 1 201 ? 42.20309  5.78778   13.44049 1.000 67.65677  ? 201 MET B SD  1 
ATOM   3254 C  CE  . MET B 1 201 ? 42.23553  7.58137   13.48484 1.000 55.10075  ? 201 MET B CE  1 
ATOM   3255 N  N   . PHE B 1 202 ? 41.20187  5.78942   18.30981 1.000 62.45534  ? 202 PHE B N   1 
ATOM   3256 C  CA  . PHE B 1 202 ? 40.53131  7.00135   18.76209 1.000 62.61602  ? 202 PHE B CA  1 
ATOM   3257 C  C   . PHE B 1 202 ? 41.09922  8.22313   18.05173 1.000 52.84725  ? 202 PHE B C   1 
ATOM   3258 O  O   . PHE B 1 202 ? 42.29229  8.27114   17.75052 1.000 60.16276  ? 202 PHE B O   1 
ATOM   3259 C  CB  . PHE B 1 202 ? 40.58110  7.15994   20.26916 1.000 55.43921  ? 202 PHE B CB  1 
ATOM   3260 C  CG  . PHE B 1 202 ? 40.14536  5.93571   21.01590 1.000 51.14621  ? 202 PHE B CG  1 
ATOM   3261 C  CD1 . PHE B 1 202 ? 38.80858  5.72102   21.27829 1.000 53.54588  ? 202 PHE B CD1 1 
ATOM   3262 C  CD2 . PHE B 1 202 ? 41.05608  5.01805   21.48840 1.000 55.41640  ? 202 PHE B CD2 1 
ATOM   3263 C  CE1 . PHE B 1 202 ? 38.38558  4.61927   21.98273 1.000 46.52209  ? 202 PHE B CE1 1 
ATOM   3264 C  CE2 . PHE B 1 202 ? 40.64489  3.89857   22.20346 1.000 53.23218  ? 202 PHE B CE2 1 
ATOM   3265 C  CZ  . PHE B 1 202 ? 39.30125  3.69813   22.45045 1.000 42.07958  ? 202 PHE B CZ  1 
ATOM   3266 N  N   . TRP B 1 203 ? 40.23031  9.19507   17.74144 1.000 43.62831  ? 203 TRP B N   1 
ATOM   3267 C  CA  . TRP B 1 203 ? 40.74629  10.40949  17.11606 1.000 54.30695  ? 203 TRP B CA  1 
ATOM   3268 C  C   . TRP B 1 203 ? 39.86582  11.60712  17.43781 1.000 55.48906  ? 203 TRP B C   1 
ATOM   3269 O  O   . TRP B 1 203 ? 38.66186  11.47855  17.68067 1.000 51.43888  ? 203 TRP B O   1 
ATOM   3270 C  CB  . TRP B 1 203 ? 40.90682  10.25887  15.58493 1.000 43.02773  ? 203 TRP B CB  1 
ATOM   3271 C  CG  . TRP B 1 203 ? 39.65340  10.45088  14.72585 1.000 43.54626  ? 203 TRP B CG  1 
ATOM   3272 C  CD1 . TRP B 1 203 ? 39.21210  11.61648  14.14217 1.000 40.73929  ? 203 TRP B CD1 1 
ATOM   3273 C  CD2 . TRP B 1 203 ? 38.70447  9.43647   14.35120 1.000 41.59048  ? 203 TRP B CD2 1 
ATOM   3274 N  NE1 . TRP B 1 203 ? 38.05138  11.38217  13.43483 1.000 44.97472  ? 203 TRP B NE1 1 
ATOM   3275 C  CE2 . TRP B 1 203 ? 37.71714  10.05601  13.54990 1.000 42.25312  ? 203 TRP B CE2 1 
ATOM   3276 C  CE3 . TRP B 1 203 ? 38.59495  8.06750   14.61687 1.000 34.33311  ? 203 TRP B CE3 1 
ATOM   3277 C  CZ2 . TRP B 1 203 ? 36.62735  9.35019   13.02341 1.000 49.40160  ? 203 TRP B CZ2 1 
ATOM   3278 C  CZ3 . TRP B 1 203 ? 37.51599  7.36521   14.08567 1.000 42.16457  ? 203 TRP B CZ3 1 
ATOM   3279 C  CH2 . TRP B 1 203 ? 36.54352  8.00931   13.30613 1.000 44.04467  ? 203 TRP B CH2 1 
ATOM   3280 N  N   . SER B 1 204 ? 40.50469  12.78932  17.39850 1.000 62.31613  ? 204 SER B N   1 
ATOM   3281 C  CA  . SER B 1 204 ? 39.85050  14.08813  17.55494 1.000 56.31783  ? 204 SER B CA  1 
ATOM   3282 C  C   . SER B 1 204 ? 39.62078  14.67050  16.16614 1.000 60.50737  ? 204 SER B C   1 
ATOM   3283 O  O   . SER B 1 204 ? 40.55164  15.16869  15.52674 1.000 65.35041  ? 204 SER B O   1 
ATOM   3284 C  CB  . SER B 1 204 ? 40.68817  15.03633  18.40802 1.000 57.77345  ? 204 SER B CB  1 
ATOM   3285 O  OG  . SER B 1 204 ? 41.05168  14.41191  19.62853 1.000 60.40339  ? 204 SER B OG  1 
ATOM   3286 N  N   . ASP B 1 205 ? 38.37281  14.61679  15.71105 1.000 63.94290  ? 205 ASP B N   1 
ATOM   3287 C  CA  . ASP B 1 205 ? 38.04552  14.86607  14.31569 1.000 62.13421  ? 205 ASP B CA  1 
ATOM   3288 C  C   . ASP B 1 205 ? 38.33156  16.29488  13.87377 1.000 67.97178  ? 205 ASP B C   1 
ATOM   3289 O  O   . ASP B 1 205 ? 38.34445  16.56327  12.66757 1.000 74.66123  ? 205 ASP B O   1 
ATOM   3290 C  CB  . ASP B 1 205 ? 36.57944  14.51492  14.09639 1.000 58.67905  ? 205 ASP B CB  1 
ATOM   3291 C  CG  . ASP B 1 205 ? 36.24661  14.30056  12.65866 1.000 61.38846  ? 205 ASP B CG  1 
ATOM   3292 O  OD1 . ASP B 1 205 ? 36.73467  13.29641  12.09573 1.000 52.63474  ? 205 ASP B OD1 1 
ATOM   3293 O  OD2 . ASP B 1 205 ? 35.47830  15.12167  12.11236 1.000 67.61460  ? 205 ASP B OD2 1 
ATOM   3294 N  N   . GLY B 1 206 ? 38.54058  17.21288  14.80814 1.000 69.15344  ? 206 GLY B N   1 
ATOM   3295 C  CA  . GLY B 1 206 ? 38.81996  18.58712  14.45563 1.000 66.94124  ? 206 GLY B CA  1 
ATOM   3296 C  C   . GLY B 1 206 ? 40.27971  18.92471  14.47652 1.000 71.07014  ? 206 GLY B C   1 
ATOM   3297 O  O   . GLY B 1 206 ? 40.67118  20.02100  14.06060 1.000 73.91902  ? 206 GLY B O   1 
ATOM   3298 N  N   . GLN B 1 207 ? 41.10451  17.97626  14.91490 1.000 65.60727  ? 207 GLN B N   1 
ATOM   3299 C  CA  . GLN B 1 207 ? 42.54490  18.17411  14.93839 1.000 63.82896  ? 207 GLN B CA  1 
ATOM   3300 C  C   . GLN B 1 207 ? 43.22505  17.59102  13.70218 1.000 75.62024  ? 207 GLN B C   1 
ATOM   3301 O  O   . GLN B 1 207 ? 44.15708  18.18917  13.15140 1.000 81.59459  ? 207 GLN B O   1 
ATOM   3302 C  CB  . GLN B 1 207 ? 43.12378  17.54648  16.20715 1.000 65.79435  ? 207 GLN B CB  1 
ATOM   3303 C  CG  . GLN B 1 207 ? 44.60640  17.62677  16.29147 1.000 74.37303  ? 207 GLN B CG  1 
ATOM   3304 C  CD  . GLN B 1 207 ? 45.10221  17.74468  17.71005 1.000 80.95264  ? 207 GLN B CD  1 
ATOM   3305 O  OE1 . GLN B 1 207 ? 45.82097  16.86583  18.20411 1.000 84.13771  ? 207 GLN B OE1 1 
ATOM   3306 N  NE2 . GLN B 1 207 ? 44.73005  18.82897  18.37793 1.000 88.69055  ? 207 GLN B NE2 1 
ATOM   3307 N  N   . ILE B 1 208 ? 42.76732  16.42929  13.24817 1.000 62.66062  ? 208 ILE B N   1 
ATOM   3308 C  CA  . ILE B 1 208 ? 43.40458  15.69927  12.16572 1.000 66.76804  ? 208 ILE B CA  1 
ATOM   3309 C  C   . ILE B 1 208 ? 42.43135  15.55873  10.99371 1.000 66.45921  ? 208 ILE B C   1 
ATOM   3310 O  O   . ILE B 1 208 ? 41.24991  15.88108  11.08074 1.000 64.34521  ? 208 ILE B O   1 
ATOM   3311 C  CB  . ILE B 1 208 ? 43.91814  14.30708  12.60721 1.000 58.00981  ? 208 ILE B CB  1 
ATOM   3312 C  CG1 . ILE B 1 208 ? 42.76023  13.42878  13.06255 1.000 62.53021  ? 208 ILE B CG1 1 
ATOM   3313 C  CG2 . ILE B 1 208 ? 44.96751  14.42403  13.70866 1.000 54.36418  ? 208 ILE B CG2 1 
ATOM   3314 C  CD1 . ILE B 1 208 ? 42.37839  12.34855  12.06526 1.000 58.96395  ? 208 ILE B CD1 1 
ATOM   3315 N  N   . LEU B 1 209 ? 42.96654  15.08186  9.87976  1.000 70.84067  ? 209 LEU B N   1 
ATOM   3316 C  CA  . LEU B 1 209 ? 42.18586  14.52813  8.78769  1.000 72.39217  ? 209 LEU B CA  1 
ATOM   3317 C  C   . LEU B 1 209 ? 42.55068  13.05597  8.66494  1.000 67.87554  ? 209 LEU B C   1 
ATOM   3318 O  O   . LEU B 1 209 ? 43.63373  12.63447  9.08266  1.000 59.67446  ? 209 LEU B O   1 
ATOM   3319 C  CB  . LEU B 1 209 ? 42.45138  15.26028  7.46639  1.000 67.87532  ? 209 LEU B CB  1 
ATOM   3320 C  CG  . LEU B 1 209 ? 42.17568  16.76505  7.48753  1.000 76.86073  ? 209 LEU B CG  1 
ATOM   3321 C  CD1 . LEU B 1 209 ? 42.71805  17.42974  6.23059  1.000 87.40665  ? 209 LEU B CD1 1 
ATOM   3322 C  CD2 . LEU B 1 209 ? 40.68919  17.04684  7.64800  1.000 67.60609  ? 209 LEU B CD2 1 
ATOM   3323 N  N   . HIS B 1 210 ? 41.64184  12.26200  8.11151  1.000 58.20744  ? 210 HIS B N   1 
ATOM   3324 C  CA  . HIS B 1 210 ? 41.86632  10.82632  8.09095  1.000 57.55894  ? 210 HIS B CA  1 
ATOM   3325 C  C   . HIS B 1 210 ? 41.31387  10.23936  6.80566  1.000 62.87210  ? 210 HIS B C   1 
ATOM   3326 O  O   . HIS B 1 210 ? 40.49736  10.85743  6.11528  1.000 62.01947  ? 210 HIS B O   1 
ATOM   3327 C  CB  . HIS B 1 210 ? 41.22731  10.12907  9.30648  1.000 59.86406  ? 210 HIS B CB  1 
ATOM   3328 C  CG  . HIS B 1 210 ? 39.73186  10.05282  9.24181  1.000 61.05621  ? 210 HIS B CG  1 
ATOM   3329 N  ND1 . HIS B 1 210 ? 38.91523  11.08432  9.65477  1.000 54.82225  ? 210 HIS B ND1 1 
ATOM   3330 C  CD2 . HIS B 1 210 ? 38.90608  9.07347   8.79755  1.000 55.69017  ? 210 HIS B CD2 1 
ATOM   3331 C  CE1 . HIS B 1 210 ? 37.65137  10.74101  9.47486  1.000 56.14624  ? 210 HIS B CE1 1 
ATOM   3332 N  NE2 . HIS B 1 210 ? 37.61833  9.52469   8.95885  1.000 55.67444  ? 210 HIS B NE2 1 
ATOM   3333 N  N   . ALA B 1 211 ? 41.77855  9.02760   6.50170  1.000 56.25436  ? 211 ALA B N   1 
ATOM   3334 C  CA  . ALA B 1 211 ? 41.29143  8.25971   5.36639  1.000 62.79292  ? 211 ALA B CA  1 
ATOM   3335 C  C   . ALA B 1 211 ? 41.69488  6.80671   5.56055  1.000 61.08035  ? 211 ALA B C   1 
ATOM   3336 O  O   . ALA B 1 211 ? 42.46081  6.46730   6.46140  1.000 53.23757  ? 211 ALA B O   1 
ATOM   3337 C  CB  . ALA B 1 211 ? 41.83323  8.80778   4.04137  1.000 71.93229  ? 211 ALA B CB  1 
ATOM   3338 N  N   . VAL B 1 212 ? 41.17394  5.94835   4.69368  1.000 68.23733  ? 212 VAL B N   1 
ATOM   3339 C  CA  . VAL B 1 212 ? 41.50082  4.52972   4.71638  1.000 67.19765  ? 212 VAL B CA  1 
ATOM   3340 C  C   . VAL B 1 212 ? 41.80275  4.07877   3.29403  1.000 66.42097  ? 212 VAL B C   1 
ATOM   3341 O  O   . VAL B 1 212 ? 41.03230  4.35731   2.36773  1.000 71.13464  ? 212 VAL B O   1 
ATOM   3342 C  CB  . VAL B 1 212 ? 40.36945  3.68331   5.33485  1.000 72.19753  ? 212 VAL B CB  1 
ATOM   3343 C  CG1 . VAL B 1 212 ? 39.04335  3.87862   4.59300  1.000 66.71102  ? 212 VAL B CG1 1 
ATOM   3344 C  CG2 . VAL B 1 212 ? 40.75606  2.22330   5.34458  1.000 64.77677  ? 212 VAL B CG2 1 
ATOM   3345 N  N   . ARG B 1 213 ? 42.93264  3.40408   3.11451  1.000 74.86741  ? 213 ARG B N   1 
ATOM   3346 C  CA  . ARG B 1 213 ? 43.29523  2.95548   1.78152  1.000 75.02414  ? 213 ARG B CA  1 
ATOM   3347 C  C   . ARG B 1 213 ? 42.32760  1.86398   1.33440  1.000 68.75415  ? 213 ARG B C   1 
ATOM   3348 O  O   . ARG B 1 213 ? 41.71378  1.19259   2.16609  1.000 68.24078  ? 213 ARG B O   1 
ATOM   3349 C  CB  . ARG B 1 213 ? 44.73760  2.45068   1.74769  1.000 61.81638  ? 213 ARG B CB  1 
ATOM   3350 C  CG  . ARG B 1 213 ? 45.73881  3.54426   2.05296  1.000 70.48999  ? 213 ARG B CG  1 
ATOM   3351 C  CD  . ARG B 1 213 ? 46.95341  3.51154   1.13947  1.000 78.97825  ? 213 ARG B CD  1 
ATOM   3352 N  NE  . ARG B 1 213 ? 46.59814  3.73096   -0.25625 1.000 75.94779  ? 213 ARG B NE  1 
ATOM   3353 C  CZ  . ARG B 1 213 ? 46.59213  2.77820   -1.17507 1.000 73.56927  ? 213 ARG B CZ  1 
ATOM   3354 N  NH1 . ARG B 1 213 ? 46.98842  1.54483   -0.89389 1.000 76.84455  ? 213 ARG B NH1 1 
ATOM   3355 N  NH2 . ARG B 1 213 ? 46.17422  3.06734   -2.40228 1.000 74.64260  ? 213 ARG B NH2 1 
ATOM   3356 N  N   . PRO B 1 214 ? 42.13118  1.70240   0.02939  1.000 80.62852  ? 214 PRO B N   1 
ATOM   3357 C  CA  . PRO B 1 214 ? 41.22248  0.65607   -0.44809 1.000 75.66623  ? 214 PRO B CA  1 
ATOM   3358 C  C   . PRO B 1 214 ? 41.76882  -0.72337  -0.12794 1.000 68.01379  ? 214 PRO B C   1 
ATOM   3359 O  O   . PRO B 1 214 ? 42.96585  -0.91354  0.08758  1.000 77.53117  ? 214 PRO B O   1 
ATOM   3360 C  CB  . PRO B 1 214 ? 41.16036  0.89368   -1.96215 1.000 78.66703  ? 214 PRO B CB  1 
ATOM   3361 C  CG  . PRO B 1 214 ? 41.64824  2.30556   -2.15948 1.000 82.30315  ? 214 PRO B CG  1 
ATOM   3362 C  CD  . PRO B 1 214 ? 42.65334  2.52866   -1.07438 1.000 82.28086  ? 214 PRO B CD  1 
ATOM   3363 N  N   . ILE B 1 215 ? 40.86830  -1.69109  -0.08738 1.000 66.08439  ? 215 ILE B N   1 
ATOM   3364 C  CA  . ILE B 1 215 ? 41.24442  -3.08831  0.10513  1.000 79.31969  ? 215 ILE B CA  1 
ATOM   3365 C  C   . ILE B 1 215 ? 41.08045  -3.82874  -1.21632 1.000 86.16036  ? 215 ILE B C   1 
ATOM   3366 O  O   . ILE B 1 215 ? 40.21573  -3.49862  -2.04096 1.000 86.94161  ? 215 ILE B O   1 
ATOM   3367 C  CB  . ILE B 1 215 ? 40.42610  -3.78145  1.22184  1.000 83.97202  ? 215 ILE B CB  1 
ATOM   3368 C  CG1 . ILE B 1 215 ? 38.92800  -3.76005  0.90582  1.000 80.35316  ? 215 ILE B CG1 1 
ATOM   3369 C  CG2 . ILE B 1 215 ? 40.71216  -3.15663  2.58647  1.000 75.70781  ? 215 ILE B CG2 1 
ATOM   3370 C  CD1 . ILE B 1 215 ? 38.11241  -4.73818  1.73632  1.000 74.86797  ? 215 ILE B CD1 1 
ATOM   3371 N  N   . HIS B 1 216 ? 41.91699  -4.84545  -1.41909 1.000 84.27305  ? 216 HIS B N   1 
ATOM   3372 C  CA  . HIS B 1 216 ? 41.84085  -5.70377  -2.59261 1.000 84.54190  ? 216 HIS B CA  1 
ATOM   3373 C  C   . HIS B 1 216 ? 42.07940  -7.13459  -2.14280 1.000 84.31131  ? 216 HIS B C   1 
ATOM   3374 O  O   . HIS B 1 216 ? 42.74075  -7.35964  -1.12066 1.000 82.93116  ? 216 HIS B O   1 
ATOM   3375 C  CB  . HIS B 1 216 ? 42.85356  -5.29227  -3.67985 1.000 83.13839  ? 216 HIS B CB  1 
ATOM   3376 C  CG  . HIS B 1 216 ? 44.29059  -5.51004  -3.30390 1.000 95.24132  ? 216 HIS B CG  1 
ATOM   3377 N  ND1 . HIS B 1 216 ? 45.04610  -4.55543  -2.65443 1.000 98.46170  ? 216 HIS B ND1 1 
ATOM   3378 C  CD2 . HIS B 1 216 ? 45.11722  -6.56533  -3.50820 1.000 99.99930  ? 216 HIS B CD2 1 
ATOM   3379 C  CE1 . HIS B 1 216 ? 46.27005  -5.01817  -2.46172 1.000 101.58603 ? 216 HIS B CE1 1 
ATOM   3380 N  NE2 . HIS B 1 216 ? 46.34027  -6.23516  -2.97244 1.000 107.74819 ? 216 HIS B NE2 1 
ATOM   3381 N  N   . PRO B 1 217 ? 41.54048  -8.11799  -2.85700 1.000 82.95725  ? 217 PRO B N   1 
ATOM   3382 C  CA  . PRO B 1 217 ? 41.66722  -9.50695  -2.40310 1.000 84.97284  ? 217 PRO B CA  1 
ATOM   3383 C  C   . PRO B 1 217 ? 43.08365  -10.04048 -2.54291 1.000 85.77121  ? 217 PRO B C   1 
ATOM   3384 O  O   . PRO B 1 217 ? 43.82344  -9.68276  -3.46274 1.000 96.12603  ? 217 PRO B O   1 
ATOM   3385 C  CB  . PRO B 1 217 ? 40.69847  -10.27100 -3.31346 1.000 82.19540  ? 217 PRO B CB  1 
ATOM   3386 C  CG  . PRO B 1 217 ? 40.52143  -9.40472  -4.51096 1.000 84.81194  ? 217 PRO B CG  1 
ATOM   3387 C  CD  . PRO B 1 217 ? 40.64823  -7.99099  -4.02275 1.000 86.15098  ? 217 PRO B CD  1 
ATOM   3388 N  N   . VAL B 1 218 ? 43.45641  -10.91018 -1.60235 1.000 83.77596  ? 218 VAL B N   1 
ATOM   3389 C  CA  . VAL B 1 218 ? 44.72035  -11.63566 -1.70759 1.000 85.48011  ? 218 VAL B CA  1 
ATOM   3390 C  C   . VAL B 1 218 ? 44.58928  -12.78626 -2.69480 1.000 93.54924  ? 218 VAL B C   1 
ATOM   3391 O  O   . VAL B 1 218 ? 45.35308  -12.89179 -3.66323 1.000 94.80016  ? 218 VAL B O   1 
ATOM   3392 C  CB  . VAL B 1 218 ? 45.17372  -12.13241 -0.32541 1.000 85.03812  ? 218 VAL B CB  1 
ATOM   3393 C  CG1 . VAL B 1 218 ? 46.48814  -12.89365 -0.44260 1.000 75.46497  ? 218 VAL B CG1 1 
ATOM   3394 C  CG2 . VAL B 1 218 ? 45.30832  -10.95210 0.62814  1.000 87.68271  ? 218 VAL B CG2 1 
ATOM   3395 N  N   . ASP B 1 219 ? 43.61367  -13.66210 -2.46140 1.000 86.62427  ? 219 ASP B N   1 
ATOM   3396 C  CA  . ASP B 1 219 ? 43.21307  -14.65697 -3.44330 1.000 87.20418  ? 219 ASP B CA  1 
ATOM   3397 C  C   . ASP B 1 219 ? 42.34891  -13.97308 -4.49422 1.000 90.86172  ? 219 ASP B C   1 
ATOM   3398 O  O   . ASP B 1 219 ? 41.20071  -13.61163 -4.20592 1.000 91.10049  ? 219 ASP B O   1 
ATOM   3399 C  CB  . ASP B 1 219 ? 42.45299  -15.79756 -2.77232 1.000 82.20544  ? 219 ASP B CB  1 
ATOM   3400 C  CG  . ASP B 1 219 ? 41.98194  -16.84541 -3.75683 1.000 92.60028  ? 219 ASP B CG  1 
ATOM   3401 O  OD1 . ASP B 1 219 ? 42.39889  -16.80317 -4.93841 1.000 91.61451  ? 219 ASP B OD1 1 
ATOM   3402 O  OD2 . ASP B 1 219 ? 41.18745  -17.71799 -3.34348 1.000 84.03763  ? 219 ASP B OD2 1 
ATOM   3403 N  N   . PRO B 1 220 ? 42.85129  -13.78189 -5.71901 1.000 94.65041  ? 220 PRO B N   1 
ATOM   3404 C  CA  . PRO B 1 220 ? 42.07127  -13.03806 -6.72241 1.000 93.16564  ? 220 PRO B CA  1 
ATOM   3405 C  C   . PRO B 1 220 ? 40.69864  -13.64267 -7.01774 1.000 92.95853  ? 220 PRO B C   1 
ATOM   3406 O  O   . PRO B 1 220 ? 39.88480  -12.97199 -7.66681 1.000 91.52650  ? 220 PRO B O   1 
ATOM   3407 C  CB  . PRO B 1 220 ? 42.97913  -13.06179 -7.96368 1.000 91.44255  ? 220 PRO B CB  1 
ATOM   3408 C  CG  . PRO B 1 220 ? 44.36163  -13.31649 -7.42571 1.000 93.27588  ? 220 PRO B CG  1 
ATOM   3409 C  CD  . PRO B 1 220 ? 44.15421  -14.22464 -6.25051 1.000 92.19072  ? 220 PRO B CD  1 
ATOM   3410 N  N   . THR B 1 221 ? 40.40827  -14.86161 -6.54065 1.000 94.02726  ? 221 THR B N   1 
ATOM   3411 C  CA  . THR B 1 221 ? 39.15216  -15.54536 -6.83754 1.000 95.02403  ? 221 THR B CA  1 
ATOM   3412 C  C   . THR B 1 221 ? 38.10648  -15.33566 -5.76220 1.000 89.05031  ? 221 THR B C   1 
ATOM   3413 O  O   . THR B 1 221 ? 36.92663  -15.60988 -5.99494 1.000 90.38720  ? 221 THR B O   1 
ATOM   3414 C  CB  . THR B 1 221 ? 39.37919  -17.05539 -7.01255 1.000 96.09929  ? 221 THR B CB  1 
ATOM   3415 O  OG1 . THR B 1 221 ? 39.48767  -17.68448 -5.72657 1.000 91.54662  ? 221 THR B OG1 1 
ATOM   3416 C  CG2 . THR B 1 221 ? 40.64171  -17.31229 -7.82633 1.000 94.07251  ? 221 THR B CG2 1 
ATOM   3417 N  N   . LYS B 1 222 ? 38.51875  -14.90232 -4.58504 1.000 90.46370  ? 222 LYS B N   1 
ATOM   3418 C  CA  . LYS B 1 222 ? 37.59677  -14.57404 -3.51691 1.000 88.32413  ? 222 LYS B CA  1 
ATOM   3419 C  C   . LYS B 1 222 ? 37.57992  -13.07253 -3.30544 1.000 88.86104  ? 222 LYS B C   1 
ATOM   3420 O  O   . LYS B 1 222 ? 38.48807  -12.35306 -3.70438 1.000 84.88874  ? 222 LYS B O   1 
ATOM   3421 C  CB  . LYS B 1 222 ? 37.97582  -15.25141 -2.20015 1.000 86.08515  ? 222 LYS B CB  1 
ATOM   3422 C  CG  . LYS B 1 222 ? 37.99271  -16.76061 -2.27399 1.000 87.08276  ? 222 LYS B CG  1 
ATOM   3423 C  CD  . LYS B 1 222 ? 38.31846  -17.41794 -0.93220 1.000 82.57100  ? 222 LYS B CD  1 
ATOM   3424 C  CE  . LYS B 1 222 ? 37.40238  -16.91986 0.16823  1.000 94.21101  ? 222 LYS B CE  1 
ATOM   3425 N  NZ  . LYS B 1 222 ? 37.62326  -17.59639 1.48185  1.000 101.03922 ? 222 LYS B NZ  1 
ATOM   3426 N  N   . ALA B 1 223 ? 36.53047  -12.60085 -2.65334 1.000 88.35622  ? 223 ALA B N   1 
ATOM   3427 C  CA  . ALA B 1 223 ? 36.33691  -11.16566 -2.45379 1.000 86.58875  ? 223 ALA B CA  1 
ATOM   3428 C  C   . ALA B 1 223 ? 37.01849  -10.75714 -1.15156 1.000 79.11103  ? 223 ALA B C   1 
ATOM   3429 O  O   . ALA B 1 223 ? 37.33262  -11.60190 -0.30930 1.000 72.45128  ? 223 ALA B O   1 
ATOM   3430 C  CB  . ALA B 1 223 ? 34.83708  -10.78829 -2.44398 1.000 69.58461  ? 223 ALA B CB  1 
ATOM   3431 N  N   . ALA B 1 224 ? 37.40386  -9.48542  -1.06436 1.000 85.04323  ? 224 ALA B N   1 
ATOM   3432 C  CA  . ALA B 1 224 ? 37.89068  -8.90992  0.18822  1.000 82.90215  ? 224 ALA B CA  1 
ATOM   3433 C  C   . ALA B 1 224 ? 36.73126  -8.30643  0.97614  1.000 81.54659  ? 224 ALA B C   1 
ATOM   3434 O  O   . ALA B 1 224 ? 35.93054  -7.53922  0.42765  1.000 75.79245  ? 224 ALA B O   1 
ATOM   3435 C  CB  . ALA B 1 224 ? 38.95024  -7.83004  -0.04926 1.000 80.18739  ? 224 ALA B CB  1 
ATOM   3436 N  N   . VAL B 1 225 ? 36.67073  -8.60655  2.27232  1.000 79.42345  ? 225 VAL B N   1 
ATOM   3437 C  CA  . VAL B 1 225 ? 35.60496  -8.09340  3.13072  1.000 85.55775  ? 225 VAL B CA  1 
ATOM   3438 C  C   . VAL B 1 225 ? 36.22137  -7.53216  4.40790  1.000 77.87693  ? 225 VAL B C   1 
ATOM   3439 O  O   . VAL B 1 225 ? 36.96086  -8.23378  5.11040  1.000 72.63619  ? 225 VAL B O   1 
ATOM   3440 C  CB  . VAL B 1 225 ? 34.54731  -9.16521  3.45124  1.000 77.05859  ? 225 VAL B CB  1 
ATOM   3441 C  CG1 . VAL B 1 225 ? 33.54699  -8.64025  4.47043  1.000 73.98732  ? 225 VAL B CG1 1 
ATOM   3442 C  CG2 . VAL B 1 225 ? 33.81652  -9.57941  2.17965  1.000 77.49597  ? 225 VAL B CG2 1 
ATOM   3443 N  N   . ARG B 1 226 ? 35.92539  -6.26570  4.69661  1.000 76.14570  ? 226 ARG B N   1 
ATOM   3444 C  CA  . ARG B 1 226 ? 36.42386  -5.57070  5.87663  1.000 74.69570  ? 226 ARG B CA  1 
ATOM   3445 C  C   . ARG B 1 226 ? 35.22356  -5.02621  6.63228  1.000 68.52931  ? 226 ARG B C   1 
ATOM   3446 O  O   . ARG B 1 226 ? 34.48230  -4.19251  6.10166  1.000 66.11551  ? 226 ARG B O   1 
ATOM   3447 C  CB  . ARG B 1 226 ? 37.38085  -4.44074  5.48842  1.000 72.03374  ? 226 ARG B CB  1 
ATOM   3448 C  CG  . ARG B 1 226 ? 38.09908  -3.81529  6.66384  1.000 69.36861  ? 226 ARG B CG  1 
ATOM   3449 C  CD  . ARG B 1 226 ? 38.90957  -2.62318  6.21409  1.000 64.56909  ? 226 ARG B CD  1 
ATOM   3450 N  NE  . ARG B 1 226 ? 39.67689  -2.03546  7.30481  1.000 61.78216  ? 226 ARG B NE  1 
ATOM   3451 C  CZ  . ARG B 1 226 ? 39.38342  -0.88494  7.89966  1.000 62.00529  ? 226 ARG B CZ  1 
ATOM   3452 N  NH1 . ARG B 1 226 ? 38.33144  -0.16160  7.53754  1.000 54.09777  ? 226 ARG B NH1 1 
ATOM   3453 N  NH2 . ARG B 1 226 ? 40.16822  -0.44332  8.87738  1.000 51.04259  ? 226 ARG B NH2 1 
ATOM   3454 N  N   . ASP B 1 227 ? 35.03058  -5.49977  7.85859  1.000 67.27587  ? 227 ASP B N   1 
ATOM   3455 C  CA  . ASP B 1 227 ? 33.86187  -5.16231  8.66553  1.000 60.28030  ? 227 ASP B CA  1 
ATOM   3456 C  C   . ASP B 1 227 ? 34.24922  -4.18701  9.77273  1.000 63.31016  ? 227 ASP B C   1 
ATOM   3457 O  O   . ASP B 1 227 ? 35.04401  -4.52692  10.65647 1.000 57.56765  ? 227 ASP B O   1 
ATOM   3458 C  CB  . ASP B 1 227 ? 33.24358  -6.42362  9.25905  1.000 58.12153  ? 227 ASP B CB  1 
ATOM   3459 C  CG  . ASP B 1 227 ? 32.63977  -7.31755  8.20383  1.000 65.56149  ? 227 ASP B CG  1 
ATOM   3460 O  OD1 . ASP B 1 227 ? 32.20315  -6.78700  7.15138  1.000 60.06639  ? 227 ASP B OD1 1 
ATOM   3461 O  OD2 . ASP B 1 227 ? 32.60640  -8.55135  8.42800  1.000 66.73663  ? 227 ASP B OD2 1 
ATOM   3462 N  N   . VAL B 1 228 ? 33.66249  -2.99388  9.73816  1.000 55.81553  ? 228 VAL B N   1 
ATOM   3463 C  CA  . VAL B 1 228 ? 34.04451  -1.89286  10.60881 1.000 54.43579  ? 228 VAL B CA  1 
ATOM   3464 C  C   . VAL B 1 228 ? 32.80842  -1.36619  11.34274 1.000 49.27940  ? 228 VAL B C   1 
ATOM   3465 O  O   . VAL B 1 228 ? 31.69883  -1.34972  10.80007 1.000 44.86393  ? 228 VAL B O   1 
ATOM   3466 C  CB  . VAL B 1 228 ? 34.76148  -0.78959  9.77624  1.000 49.41740  ? 228 VAL B CB  1 
ATOM   3467 C  CG1 . VAL B 1 228 ? 34.36855  0.60996   10.21228 1.000 61.07993  ? 228 VAL B CG1 1 
ATOM   3468 C  CG2 . VAL B 1 228 ? 36.25014  -0.96824  9.86746  1.000 50.06521  ? 228 VAL B CG2 1 
ATOM   3469 N  N   . LEU B 1 229 ? 33.00293  -0.97091  12.60764 1.000 52.16853  ? 229 LEU B N   1 
ATOM   3470 C  CA  . LEU B 1 229 ? 31.99995  -0.27967  13.42138 1.000 38.51377  ? 229 LEU B CA  1 
ATOM   3471 C  C   . LEU B 1 229 ? 32.56384  1.08551   13.79059 1.000 42.45943  ? 229 LEU B C   1 
ATOM   3472 O  O   . LEU B 1 229 ? 33.62993  1.17385   14.41295 1.000 38.39342  ? 229 LEU B O   1 
ATOM   3473 C  CB  . LEU B 1 229 ? 31.65115  -1.07511  14.69371 1.000 47.94910  ? 229 LEU B CB  1 
ATOM   3474 C  CG  . LEU B 1 229 ? 30.78921  -0.39653  15.79134 1.000 41.78651  ? 229 LEU B CG  1 
ATOM   3475 C  CD1 . LEU B 1 229 ? 29.38454  -0.06388  15.27835 1.000 33.29219  ? 229 LEU B CD1 1 
ATOM   3476 C  CD2 . LEU B 1 229 ? 30.69540  -1.22679  17.09814 1.000 35.73085  ? 229 LEU B CD2 1 
ATOM   3477 N  N   . ILE B 1 230 ? 31.87273  2.14849   13.40502 1.000 36.79982  ? 230 ILE B N   1 
ATOM   3478 C  CA  . ILE B 1 230 ? 32.38080  3.48060   13.67853 1.000 41.63602  ? 230 ILE B CA  1 
ATOM   3479 C  C   . ILE B 1 230 ? 31.28910  4.31527   14.32670 1.000 46.19564  ? 230 ILE B C   1 
ATOM   3480 O  O   . ILE B 1 230 ? 30.10424  4.20430   13.99346 1.000 48.19556  ? 230 ILE B O   1 
ATOM   3481 C  CB  . ILE B 1 230 ? 32.94013  4.15978   12.40452 1.000 45.24793  ? 230 ILE B CB  1 
ATOM   3482 C  CG1 . ILE B 1 230 ? 32.80421  5.68470   12.47430 1.000 40.44603  ? 230 ILE B CG1 1 
ATOM   3483 C  CG2 . ILE B 1 230 ? 32.33310  3.56234   11.16100 1.000 55.23000  ? 230 ILE B CG2 1 
ATOM   3484 C  CD1 . ILE B 1 230 ? 32.67911  6.36121   11.12482 1.000 70.76191  ? 230 ILE B CD1 1 
ATOM   3485 N  N   . MET B 1 231 ? 31.69859  5.15122   15.27427 1.000 38.23824  ? 231 MET B N   1 
ATOM   3486 C  CA  . MET B 1 231 ? 30.79107  6.05104   15.96768 1.000 40.73925  ? 231 MET B CA  1 
ATOM   3487 C  C   . MET B 1 231 ? 31.38275  7.45748   15.97788 1.000 45.72122  ? 231 MET B C   1 
ATOM   3488 O  O   . MET B 1 231 ? 32.57093  7.64503   16.27060 1.000 45.31614  ? 231 MET B O   1 
ATOM   3489 C  CB  . MET B 1 231 ? 30.50859  5.56775   17.38714 1.000 48.24846  ? 231 MET B CB  1 
ATOM   3490 C  CG  . MET B 1 231 ? 29.62771  4.32955   17.43674 1.000 43.97388  ? 231 MET B CG  1 
ATOM   3491 S  SD  . MET B 1 231 ? 29.24710  3.76709   19.10300 1.000 47.17550  ? 231 MET B SD  1 
ATOM   3492 C  CE  . MET B 1 231 ? 30.63050  2.67011   19.47644 1.000 40.15322  ? 231 MET B CE  1 
ATOM   3493 N  N   . GLY B 1 232 ? 30.55909  8.44330   15.63604 1.000 35.41439  ? 232 GLY B N   1 
ATOM   3494 C  CA  . GLY B 1 232 ? 30.95086  9.83341   15.69180 1.000 41.90745  ? 232 GLY B CA  1 
ATOM   3495 C  C   . GLY B 1 232 ? 30.16414  10.55077  16.78508 1.000 43.50423  ? 232 GLY B C   1 
ATOM   3496 O  O   . GLY B 1 232 ? 28.93593  10.46344  16.83242 1.000 46.97139  ? 232 GLY B O   1 
ATOM   3497 N  N   . TYR B 1 233 ? 30.90416  11.21517  17.66236 1.000 44.34206  ? 233 TYR B N   1 
ATOM   3498 C  CA  . TYR B 1 233 ? 30.35310  11.92132  18.81184 1.000 45.49824  ? 233 TYR B CA  1 
ATOM   3499 C  C   . TYR B 1 233 ? 30.42420  13.42494  18.55868 1.000 46.92288  ? 233 TYR B C   1 
ATOM   3500 O  O   . TYR B 1 233 ? 31.50727  13.95972  18.30890 1.000 51.19432  ? 233 TYR B O   1 
ATOM   3501 C  CB  . TYR B 1 233 ? 31.13971  11.57484  20.08037 1.000 42.07513  ? 233 TYR B CB  1 
ATOM   3502 C  CG  . TYR B 1 233 ? 31.17190  10.10563  20.50026 1.000 46.58563  ? 233 TYR B CG  1 
ATOM   3503 C  CD1 . TYR B 1 233 ? 31.79899  9.13482   19.72052 1.000 38.77733  ? 233 TYR B CD1 1 
ATOM   3504 C  CD2 . TYR B 1 233 ? 30.62517  9.70719   21.71581 1.000 44.87375  ? 233 TYR B CD2 1 
ATOM   3505 C  CE1 . TYR B 1 233 ? 31.84421  7.80355   20.12995 1.000 42.59177  ? 233 TYR B CE1 1 
ATOM   3506 C  CE2 . TYR B 1 233 ? 30.66484  8.38050   22.12959 1.000 44.57175  ? 233 TYR B CE2 1 
ATOM   3507 C  CZ  . TYR B 1 233 ? 31.27410  7.43185   21.34148 1.000 43.52497  ? 233 TYR B CZ  1 
ATOM   3508 O  OH  . TYR B 1 233 ? 31.31210  6.11359   21.76644 1.000 40.56520  ? 233 TYR B OH  1 
ATOM   3509 N  N   . LYS B 1 234 ? 29.28369  14.10862  18.63562 1.000 41.82138  ? 234 LYS B N   1 
ATOM   3510 C  CA  . LYS B 1 234 ? 29.23292  15.55589  18.48090 1.000 46.85693  ? 234 LYS B CA  1 
ATOM   3511 C  C   . LYS B 1 234 ? 28.45627  16.17068  19.63732 1.000 54.77657  ? 234 LYS B C   1 
ATOM   3512 O  O   . LYS B 1 234 ? 27.29929  15.80483  19.87870 1.000 51.11735  ? 234 LYS B O   1 
ATOM   3513 C  CB  . LYS B 1 234 ? 28.59891  15.93989  17.14467 1.000 57.07278  ? 234 LYS B CB  1 
ATOM   3514 C  CG  . LYS B 1 234 ? 28.90505  17.36326  16.72394 1.000 66.08449  ? 234 LYS B CG  1 
ATOM   3515 C  CD  . LYS B 1 234 ? 28.44366  17.62683  15.30439 1.000 66.81864  ? 234 LYS B CD  1 
ATOM   3516 C  CE  . LYS B 1 234 ? 28.92122  18.98116  14.83810 1.000 66.21838  ? 234 LYS B CE  1 
ATOM   3517 N  NZ  . LYS B 1 234 ? 28.62522  19.14414  13.38908 1.000 84.01992  ? 234 LYS B NZ  1 
ATOM   3518 N  N   . HIS B 1 235 ? 29.09531  17.10915  20.33784 1.000 56.61833  ? 235 HIS B N   1 
ATOM   3519 C  CA  . HIS B 1 235 ? 28.47162  17.83562  21.43992 1.000 57.69142  ? 235 HIS B CA  1 
ATOM   3520 C  C   . HIS B 1 235 ? 27.33111  18.70656  20.92502 1.000 64.29164  ? 235 HIS B C   1 
ATOM   3521 O  O   . HIS B 1 235 ? 27.52284  19.52400  20.01791 1.000 69.49961  ? 235 HIS B O   1 
ATOM   3522 C  CB  . HIS B 1 235 ? 29.53853  18.68235  22.13683 1.000 62.12494  ? 235 HIS B CB  1 
ATOM   3523 C  CG  . HIS B 1 235 ? 29.02936  19.51024  23.27550 1.000 69.97399  ? 235 HIS B CG  1 
ATOM   3524 N  ND1 . HIS B 1 235 ? 28.70629  20.84334  23.14073 1.000 76.13098  ? 235 HIS B ND1 1 
ATOM   3525 C  CD2 . HIS B 1 235 ? 28.82356  19.20477  24.57834 1.000 70.10673  ? 235 HIS B CD2 1 
ATOM   3526 C  CE1 . HIS B 1 235 ? 28.30844  21.31923  24.30738 1.000 71.23678  ? 235 HIS B CE1 1 
ATOM   3527 N  NE2 . HIS B 1 235 ? 28.37285  20.34605  25.19744 1.000 74.33479  ? 235 HIS B NE2 1 
ATOM   3528 N  N   . GLU B 1 236 ? 26.13951  18.51668  21.49197 1.000 63.69087  ? 236 GLU B N   1 
ATOM   3529 C  CA  . GLU B 1 236 ? 24.92169  19.19821  21.03970 1.000 70.25488  ? 236 GLU B CA  1 
ATOM   3530 C  C   . GLU B 1 236 ? 24.10628  19.65906  22.24227 1.000 69.31229  ? 236 GLU B C   1 
ATOM   3531 O  O   . GLU B 1 236 ? 23.11338  19.02676  22.61939 1.000 65.57637  ? 236 GLU B O   1 
ATOM   3532 C  CB  . GLU B 1 236 ? 24.07361  18.28231  20.14970 1.000 63.24735  ? 236 GLU B CB  1 
ATOM   3533 C  CG  . GLU B 1 236 ? 24.76381  17.81855  18.88632 1.000 70.75836  ? 236 GLU B CG  1 
ATOM   3534 C  CD  . GLU B 1 236 ? 24.81791  18.88600  17.81299 1.000 75.25635  ? 236 GLU B CD  1 
ATOM   3535 O  OE1 . GLU B 1 236 ? 24.40075  20.04182  18.07604 1.000 74.73192  ? 236 GLU B OE1 1 
ATOM   3536 O  OE2 . GLU B 1 236 ? 25.27249  18.55363  16.69678 1.000 71.43628  ? 236 GLU B OE2 1 
ATOM   3537 N  N   . PRO B 1 237 ? 24.48892  20.78509  22.85148 1.000 71.28451  ? 237 PRO B N   1 
ATOM   3538 C  CA  . PRO B 1 237 ? 23.79551  21.22437  24.07779 1.000 69.81397  ? 237 PRO B CA  1 
ATOM   3539 C  C   . PRO B 1 237 ? 22.32098  21.49650  23.88228 1.000 69.63921  ? 237 PRO B C   1 
ATOM   3540 O  O   . PRO B 1 237 ? 21.55741  21.39619  24.84978 1.000 81.48197  ? 237 PRO B O   1 
ATOM   3541 C  CB  . PRO B 1 237 ? 24.54697  22.50524  24.46584 1.000 70.13968  ? 237 PRO B CB  1 
ATOM   3542 C  CG  . PRO B 1 237 ? 25.11483  23.00096  23.17628 1.000 76.69755  ? 237 PRO B CG  1 
ATOM   3543 C  CD  . PRO B 1 237 ? 25.48489  21.76598  22.39790 1.000 71.18118  ? 237 PRO B CD  1 
ATOM   3544 N  N   . GLU B 1 238 ? 21.89025  21.83056  22.66996 1.000 67.79340  ? 238 GLU B N   1 
ATOM   3545 C  CA  . GLU B 1 238 ? 20.50245  22.17640  22.41036 1.000 76.92178  ? 238 GLU B CA  1 
ATOM   3546 C  C   . GLU B 1 238 ? 19.71340  21.04130  21.77740 1.000 70.20735  ? 238 GLU B C   1 
ATOM   3547 O  O   . GLU B 1 238 ? 18.59078  21.26556  21.31421 1.000 66.52024  ? 238 GLU B O   1 
ATOM   3548 C  CB  . GLU B 1 238 ? 20.43793  23.43185  21.53828 1.000 80.72755  ? 238 GLU B CB  1 
ATOM   3549 C  CG  . GLU B 1 238 ? 20.87745  24.67691  22.29250 1.000 85.26370  ? 238 GLU B CG  1 
ATOM   3550 C  CD  . GLU B 1 238 ? 20.11551  24.85298  23.60403 1.000 85.43157  ? 238 GLU B CD  1 
ATOM   3551 O  OE1 . GLU B 1 238 ? 18.91528  25.19821  23.55250 1.000 95.88043  ? 238 GLU B OE1 1 
ATOM   3552 O  OE2 . GLU B 1 238 ? 20.71012  24.63192  24.68532 1.000 82.70322  ? 238 GLU B OE2 1 
ATOM   3553 N  N   . LEU B 1 239 ? 20.26211  19.83214  21.75788 1.000 65.77382  ? 239 LEU B N   1 
ATOM   3554 C  CA  . LEU B 1 239 ? 19.49554  18.68343  21.29499 1.000 63.59895  ? 239 LEU B CA  1 
ATOM   3555 C  C   . LEU B 1 239 ? 18.46537  18.28627  22.34605 1.000 57.12794  ? 239 LEU B C   1 
ATOM   3556 O  O   . LEU B 1 239 ? 18.72664  18.36371  23.54858 1.000 70.28667  ? 239 LEU B O   1 
ATOM   3557 C  CB  . LEU B 1 239 ? 20.42968  17.51273  20.99743 1.000 57.20328  ? 239 LEU B CB  1 
ATOM   3558 C  CG  . LEU B 1 239 ? 19.76543  16.20053  20.59442 1.000 50.47377  ? 239 LEU B CG  1 
ATOM   3559 C  CD1 . LEU B 1 239 ? 18.99195  16.37409  19.31693 1.000 50.80004  ? 239 LEU B CD1 1 
ATOM   3560 C  CD2 . LEU B 1 239 ? 20.81052  15.11291  20.45436 1.000 58.66530  ? 239 LEU B CD2 1 
ATOM   3561 N  N   . ARG B 1 240 ? 17.28441  17.87072  21.89226 1.000 55.29776  ? 240 ARG B N   1 
ATOM   3562 C  CA  . ARG B 1 240 ? 16.18795  17.50146  22.77653 1.000 64.74999  ? 240 ARG B CA  1 
ATOM   3563 C  C   . ARG B 1 240 ? 15.82806  16.03375  22.58756 1.000 63.54023  ? 240 ARG B C   1 
ATOM   3564 O  O   . ARG B 1 240 ? 16.09280  15.43329  21.54093 1.000 59.75319  ? 240 ARG B O   1 
ATOM   3565 C  CB  . ARG B 1 240 ? 14.93013  18.36216  22.53135 1.000 73.62892  ? 240 ARG B CB  1 
ATOM   3566 C  CG  . ARG B 1 240 ? 15.14629  19.86827  22.54798 1.000 74.96731  ? 240 ARG B CG  1 
ATOM   3567 C  CD  . ARG B 1 240 ? 13.84275  20.61668  22.29311 1.000 81.25867  ? 240 ARG B CD  1 
ATOM   3568 N  NE  . ARG B 1 240 ? 12.97720  20.65676  23.47037 1.000 89.11292  ? 240 ARG B NE  1 
ATOM   3569 C  CZ  . ARG B 1 240 ? 11.90652  19.89443  23.65145 1.000 88.08001  ? 240 ARG B CZ  1 
ATOM   3570 N  NH1 . ARG B 1 240 ? 11.53631  18.99625  22.75264 1.000 89.42294  ? 240 ARG B NH1 1 
ATOM   3571 N  NH2 . ARG B 1 240 ? 11.18710  20.03994  24.76125 1.000 78.14581  ? 240 ARG B NH2 1 
ATOM   3572 N  N   . ARG B 1 241 ? 15.20004  15.46340  23.61364 1.000 46.34923  ? 241 ARG B N   1 
ATOM   3573 C  CA  . ARG B 1 241 ? 14.73513  14.09148  23.51440 1.000 47.81498  ? 241 ARG B CA  1 
ATOM   3574 C  C   . ARG B 1 241 ? 13.59074  14.00754  22.50815 1.000 51.46109  ? 241 ARG B C   1 
ATOM   3575 O  O   . ARG B 1 241 ? 12.78401  14.93105  22.37625 1.000 64.37424  ? 241 ARG B O   1 
ATOM   3576 C  CB  . ARG B 1 241 ? 14.31477  13.58083  24.89589 1.000 44.67998  ? 241 ARG B CB  1 
ATOM   3577 C  CG  . ARG B 1 241 ? 15.44806  13.74741  25.90894 1.000 41.99057  ? 241 ARG B CG  1 
ATOM   3578 C  CD  . ARG B 1 241 ? 15.09232  13.30044  27.30446 1.000 40.55439  ? 241 ARG B CD  1 
ATOM   3579 N  NE  . ARG B 1 241 ? 16.24866  13.33996  28.19637 1.000 42.06272  ? 241 ARG B NE  1 
ATOM   3580 C  CZ  . ARG B 1 241 ? 16.72280  14.44045  28.76818 1.000 49.01040  ? 241 ARG B CZ  1 
ATOM   3581 N  NH1 . ARG B 1 241 ? 16.17765  15.62454  28.54152 1.000 56.38984  ? 241 ARG B NH1 1 
ATOM   3582 N  NH2 . ARG B 1 241 ? 17.77018  14.35215  29.58824 1.000 46.27960  ? 241 ARG B NH2 1 
ATOM   3583 N  N   . GLU B 1 242 ? 13.53811  12.89455  21.77903 1.000 58.40338  ? 242 GLU B N   1 
ATOM   3584 C  CA  . GLU B 1 242 ? 12.55428  12.67320  20.72485 1.000 60.05303  ? 242 GLU B CA  1 
ATOM   3585 C  C   . GLU B 1 242 ? 11.68853  11.46614  21.05678 1.000 69.11870  ? 242 GLU B C   1 
ATOM   3586 O  O   . GLU B 1 242 ? 12.20661  10.39106  21.38006 1.000 66.00193  ? 242 GLU B O   1 
ATOM   3587 C  CB  . GLU B 1 242 ? 13.24417  12.46746  19.37417 1.000 49.47356  ? 242 GLU B CB  1 
ATOM   3588 C  CG  . GLU B 1 242 ? 13.98420  13.70196  18.88027 1.000 62.49429  ? 242 GLU B CG  1 
ATOM   3589 C  CD  . GLU B 1 242 ? 15.03153  13.38576  17.81994 1.000 63.65622  ? 242 GLU B CD  1 
ATOM   3590 O  OE1 . GLU B 1 242 ? 15.88322  12.50100  18.06292 1.000 61.67490  ? 242 GLU B OE1 1 
ATOM   3591 O  OE2 . GLU B 1 242 ? 14.99634  14.01867  16.74399 1.000 58.65130  ? 242 GLU B OE2 1 
ATOM   3592 N  N   . GLU B 1 243 ? 10.37596  11.63989  20.94861 1.000 79.57544  ? 243 GLU B N   1 
ATOM   3593 C  CA  . GLU B 1 243 ? 9.43053   10.58682  21.30706 1.000 82.86800  ? 243 GLU B CA  1 
ATOM   3594 C  C   . GLU B 1 243 ? 8.65949   10.08707  20.08592 1.000 83.95867  ? 243 GLU B C   1 
ATOM   3595 O  O   . GLU B 1 243 ? 8.83543   8.95088   19.63958 1.000 85.87022  ? 243 GLU B O   1 
ATOM   3596 C  CB  . GLU B 1 243 ? 8.45556   11.09371  22.38383 1.000 87.97770  ? 243 GLU B CB  1 
ATOM   3597 C  CG  . GLU B 1 243 ? 9.09898   11.50017  23.72670 1.000 74.56974  ? 243 GLU B CG  1 
ATOM   3598 C  CD  . GLU B 1 243 ? 9.61086   10.30556  24.54071 1.000 79.16480  ? 243 GLU B CD  1 
ATOM   3599 O  OE1 . GLU B 1 243 ? 9.12585   9.17324   24.31829 1.000 88.13823  ? 243 GLU B OE1 1 
ATOM   3600 O  OE2 . GLU B 1 243 ? 10.50435  10.49315  25.40441 1.000 67.98612  ? 243 GLU B OE2 1 
HETATM 3601 C  C1  . AKG C 2 .   ? 13.28030  -4.19040  41.01992 1.000 65.09306  ? 301 AKG A C1  1 
HETATM 3602 O  O1  . AKG C 2 .   ? 14.09162  -4.72278  41.81251 1.000 61.03960  ? 301 AKG A O1  1 
HETATM 3603 O  O2  . AKG C 2 .   ? 12.02614  -4.16605  41.02270 1.000 61.38380  ? 301 AKG A O2  1 
HETATM 3604 C  C2  . AKG C 2 .   ? 13.92714  -3.41249  39.83500 1.000 58.02122  ? 301 AKG A C2  1 
HETATM 3605 O  O5  . AKG C 2 .   ? 13.22827  -2.98937  38.92427 1.000 47.55000  ? 301 AKG A O5  1 
HETATM 3606 C  C3  . AKG C 2 .   ? 15.41804  -3.21427  39.90967 1.000 50.68001  ? 301 AKG A C3  1 
HETATM 3607 C  C4  . AKG C 2 .   ? 15.85190  -1.83706  39.44547 1.000 54.65781  ? 301 AKG A C4  1 
HETATM 3608 C  C5  . AKG C 2 .   ? 17.35284  -1.59156  39.61482 1.000 47.21852  ? 301 AKG A C5  1 
HETATM 3609 O  O3  . AKG C 2 .   ? 17.91064  -0.79099  38.83810 1.000 52.59725  ? 301 AKG A O3  1 
HETATM 3610 O  O4  . AKG C 2 .   ? 17.86990  -2.24617  40.54030 1.000 46.96931  ? 301 AKG A O4  1 
HETATM 3611 FE FE  . FE  D 3 .   ? 10.86468  -2.61510  39.13790 1.000 37.50904  ? 302 FE  A FE  1 
HETATM 3612 FE FE  . FE  E 3 .   ? 26.46540  8.40419   36.98895 1.000 118.82000 ? 303 FE  A FE  1 
HETATM 3613 C  C1  . AKG F 2 .   ? 34.32986  6.40183   6.87516  1.000 74.36211  ? 301 AKG B C1  1 
HETATM 3614 O  O1  . AKG F 2 .   ? 33.75223  5.45123   6.30505  1.000 69.48366  ? 301 AKG B O1  1 
HETATM 3615 O  O2  . AKG F 2 .   ? 33.93019  7.57997   7.00034  1.000 62.43221  ? 301 AKG B O2  1 
HETATM 3616 C  C2  . AKG F 2 .   ? 35.73670  6.09367   7.50864  1.000 78.48785  ? 301 AKG B C2  1 
HETATM 3617 O  O5  . AKG F 2 .   ? 36.38397  6.99442   8.01099  1.000 67.97481  ? 301 AKG B O5  1 
HETATM 3618 C  C3  . AKG F 2 .   ? 36.23868  4.66591   7.45459  1.000 73.06219  ? 301 AKG B C3  1 
HETATM 3619 C  C4  . AKG F 2 .   ? 37.39742  4.34418   8.38654  1.000 66.03465  ? 301 AKG B C4  1 
HETATM 3620 C  C5  . AKG F 2 .   ? 38.10784  3.00244   8.11111  1.000 72.94704  ? 301 AKG B C5  1 
HETATM 3621 O  O3  . AKG F 2 .   ? 39.26593  2.84086   8.57113  1.000 75.33329  ? 301 AKG B O3  1 
HETATM 3622 O  O4  . AKG F 2 .   ? 37.44919  2.16443   7.44380  1.000 65.45294  ? 301 AKG B O4  1 
HETATM 3623 FE FE  . FE  G 3 .   ? 35.73765  8.99118   7.88480  1.000 69.83568  ? 302 FE  B FE  1 
HETATM 3624 O  O   . HOH H 4 .   ? 0.82697   10.90410  62.03636 1.000 43.97411  ? 401 HOH A O   1 
HETATM 3625 O  O   . HOH H 4 .   ? -1.22954  14.55435  57.68735 1.000 38.12587  ? 402 HOH A O   1 
HETATM 3626 O  O   . HOH H 4 .   ? 27.13944  -7.97488  54.94201 1.000 61.97807  ? 403 HOH A O   1 
HETATM 3627 O  O   . HOH H 4 .   ? 17.35212  -10.93112 52.83928 1.000 51.97944  ? 404 HOH A O   1 
HETATM 3628 O  O   . HOH H 4 .   ? 12.05822  -7.31030  40.28682 1.000 56.58293  ? 405 HOH A O   1 
HETATM 3629 O  O   . HOH H 4 .   ? 9.20824   -5.72584  56.37447 1.000 46.83660  ? 406 HOH A O   1 
HETATM 3630 O  O   . HOH H 4 .   ? 6.37536   -13.08492 57.56528 1.000 45.57499  ? 407 HOH A O   1 
HETATM 3631 O  O   . HOH H 4 .   ? 16.48889  -5.31431  57.84372 1.000 34.22177  ? 408 HOH A O   1 
HETATM 3632 O  O   . HOH H 4 .   ? 15.06322  20.08397  39.42747 1.000 59.87226  ? 409 HOH A O   1 
HETATM 3633 O  O   . HOH H 4 .   ? 3.39700   11.48999  33.76583 1.000 42.48213  ? 410 HOH A O   1 
HETATM 3634 O  O   . HOH H 4 .   ? 12.27558  -5.22980  49.32915 1.000 52.91908  ? 411 HOH A O   1 
HETATM 3635 O  O   . HOH H 4 .   ? 13.99914  8.00838   58.95840 1.000 33.83645  ? 412 HOH A O   1 
HETATM 3636 O  O   . HOH H 4 .   ? 25.81936  0.00275   50.47720 1.000 35.05180  ? 413 HOH A O   1 
HETATM 3637 O  O   . HOH H 4 .   ? 31.23548  -3.50386  50.80854 1.000 45.14679  ? 414 HOH A O   1 
HETATM 3638 O  O   . HOH H 4 .   ? -7.22479  -17.99106 54.10996 1.000 51.43794  ? 415 HOH A O   1 
HETATM 3639 O  O   . HOH H 4 .   ? 13.03061  17.04656  46.40080 1.000 50.92004  ? 416 HOH A O   1 
HETATM 3640 O  O   . HOH H 4 .   ? 10.77045  8.44144   27.44884 1.000 49.52969  ? 417 HOH A O   1 
HETATM 3641 O  O   . HOH H 4 .   ? 32.17031  -5.86918  30.99643 1.000 38.38006  ? 418 HOH A O   1 
HETATM 3642 O  O   . HOH H 4 .   ? 5.90690   -2.16283  56.99802 1.000 32.22801  ? 419 HOH A O   1 
HETATM 3643 O  O   . HOH H 4 .   ? 21.59009  1.51952   36.41492 1.000 30.74650  ? 420 HOH A O   1 
HETATM 3644 O  O   . HOH H 4 .   ? 14.77778  -6.58896  35.76346 1.000 40.32006  ? 421 HOH A O   1 
HETATM 3645 O  O   . HOH H 4 .   ? 20.85275  4.38893   58.78251 1.000 34.81850  ? 422 HOH A O   1 
HETATM 3646 O  O   . HOH H 4 .   ? 12.00287  -1.10193  40.06627 1.000 38.98803  ? 423 HOH A O   1 
HETATM 3647 O  O   . HOH H 4 .   ? 16.54055  0.69074   37.31335 1.000 40.41117  ? 424 HOH A O   1 
HETATM 3648 O  O   . HOH H 4 .   ? 11.33029  -2.26843  60.28755 1.000 39.98007  ? 425 HOH A O   1 
HETATM 3649 O  O   . HOH H 4 .   ? 3.74170   -5.87728  28.91327 1.000 65.00609  ? 426 HOH A O   1 
HETATM 3650 O  O   . HOH H 4 .   ? 3.65003   1.01063   32.91686 1.000 47.65335  ? 427 HOH A O   1 
HETATM 3651 O  O   . HOH H 4 .   ? 28.10141  10.43357  45.63462 1.000 38.57860  ? 428 HOH A O   1 
HETATM 3652 O  O   . HOH H 4 .   ? 6.77840   -9.58933  59.68055 1.000 35.36098  ? 429 HOH A O   1 
HETATM 3653 O  O   . HOH H 4 .   ? 3.19225   1.84195   47.27352 1.000 32.36800  ? 430 HOH A O   1 
HETATM 3654 O  O   . HOH H 4 .   ? 3.30880   -10.19328 53.33672 1.000 43.84126  ? 431 HOH A O   1 
HETATM 3655 O  O   . HOH H 4 .   ? 17.22450  -8.10680  55.68565 1.000 40.52823  ? 432 HOH A O   1 
HETATM 3656 O  O   . HOH H 4 .   ? 13.68374  12.65235  31.21211 1.000 42.59529  ? 433 HOH A O   1 
HETATM 3657 O  O   . HOH H 4 .   ? 14.12265  13.64328  58.01537 1.000 66.09355  ? 434 HOH A O   1 
HETATM 3658 O  O   . HOH H 4 .   ? 5.09412   -4.26893  62.42125 1.000 43.49545  ? 435 HOH A O   1 
HETATM 3659 O  O   . HOH H 4 .   ? 6.68187   -2.36748  60.09027 1.000 40.30634  ? 436 HOH A O   1 
HETATM 3660 O  O   . HOH H 4 .   ? -3.13079  4.55196   42.70031 1.000 48.59228  ? 437 HOH A O   1 
HETATM 3661 O  O   . HOH H 4 .   ? 7.28325   1.26370   35.24954 1.000 32.54984  ? 438 HOH A O   1 
HETATM 3662 O  O   . HOH H 4 .   ? 38.74198  -6.53953  42.65410 1.000 38.75146  ? 439 HOH A O   1 
HETATM 3663 O  O   . HOH H 4 .   ? 16.44262  13.28636  32.81256 1.000 40.77462  ? 440 HOH A O   1 
HETATM 3664 O  O   . HOH H 4 .   ? 20.30925  -3.23427  57.66135 1.000 38.34469  ? 441 HOH A O   1 
HETATM 3665 O  O   . HOH H 4 .   ? 5.68555   16.15661  52.43501 1.000 38.67503  ? 442 HOH A O   1 
HETATM 3666 O  O   . HOH H 4 .   ? -1.282    -8.056    60.580   1.000 49.35636  ? 443 HOH A O   1 
HETATM 3667 O  O   . HOH H 4 .   ? 14.61533  -10.66629 53.89657 1.000 38.85119  ? 444 HOH A O   1 
HETATM 3668 O  O   . HOH H 4 .   ? 21.77173  -5.91311  38.30321 1.000 37.91047  ? 445 HOH A O   1 
HETATM 3669 O  O   . HOH H 4 .   ? 15.16452  -12.45722 49.12914 1.000 56.52202  ? 446 HOH A O   1 
HETATM 3670 O  O   . HOH H 4 .   ? -1.61890  2.12346   40.42375 1.000 48.57657  ? 447 HOH A O   1 
HETATM 3671 O  O   . HOH H 4 .   ? 28.84346  3.69224   53.73617 1.000 39.59366  ? 448 HOH A O   1 
HETATM 3672 O  O   . HOH H 4 .   ? -5.91476  6.40985   42.76385 1.000 42.66202  ? 449 HOH A O   1 
HETATM 3673 O  O   . HOH H 4 .   ? 15.90327  13.94095  46.24670 1.000 54.02279  ? 450 HOH A O   1 
HETATM 3674 O  O   . HOH H 4 .   ? 3.16064   -2.94546  44.30330 1.000 34.30677  ? 451 HOH A O   1 
HETATM 3675 O  O   . HOH H 4 .   ? 31.41992  -0.68378  40.71400 1.000 40.80541  ? 452 HOH A O   1 
HETATM 3676 O  O   . HOH H 4 .   ? 8.99886   -2.90293  60.52282 1.000 55.07290  ? 453 HOH A O   1 
HETATM 3677 O  O   . HOH H 4 .   ? 6.29096   15.83801  50.44686 1.000 34.59258  ? 454 HOH A O   1 
HETATM 3678 O  O   . HOH H 4 .   ? 25.28790  -12.23499 36.06415 1.000 52.05710  ? 455 HOH A O   1 
HETATM 3679 O  O   . HOH H 4 .   ? 34.08315  -11.97619 46.90336 1.000 49.66068  ? 456 HOH A O   1 
HETATM 3680 O  O   . HOH H 4 .   ? 11.02579  15.27177  60.69373 1.000 40.94591  ? 457 HOH A O   1 
HETATM 3681 O  O   . HOH H 4 .   ? 4.61094   -0.03710  63.30104 1.000 43.12389  ? 458 HOH A O   1 
HETATM 3682 O  O   . HOH H 4 .   ? 1.66242   7.19589   36.52639 1.000 35.20820  ? 459 HOH A O   1 
HETATM 3683 O  O   . HOH H 4 .   ? 3.77983   19.77856  49.09921 1.000 51.19681  ? 460 HOH A O   1 
HETATM 3684 O  O   . HOH H 4 .   ? 29.66653  3.34809   44.63421 1.000 41.82115  ? 461 HOH A O   1 
HETATM 3685 O  O   . HOH H 4 .   ? 30.50601  7.37936   44.62779 1.000 48.80094  ? 462 HOH A O   1 
HETATM 3686 O  O   . HOH H 4 .   ? 25.80630  -9.63203  54.89462 1.000 54.89606  ? 463 HOH A O   1 
HETATM 3687 O  O   . HOH H 4 .   ? 15.90064  -11.76489 51.40700 1.000 52.00887  ? 464 HOH A O   1 
HETATM 3688 O  O   . HOH H 4 .   ? 3.805     10.769    62.074   1.000 60.86854  ? 465 HOH A O   1 
HETATM 3689 O  O   . HOH H 4 .   ? 14.97845  0.59549   36.07484 1.000 46.22246  ? 466 HOH A O   1 
HETATM 3690 O  O   . HOH H 4 .   ? 29.45231  4.11685   51.69695 1.000 33.78498  ? 467 HOH A O   1 
HETATM 3691 O  O   . HOH H 4 .   ? 15.00740  16.47900  45.11799 1.000 51.28437  ? 468 HOH A O   1 
HETATM 3692 O  O   . HOH H 4 .   ? 24.88838  -9.72228  57.00046 1.000 52.63025  ? 469 HOH A O   1 
HETATM 3693 O  O   . HOH H 4 .   ? 6.84492   8.13209   27.30620 1.000 57.96085  ? 470 HOH A O   1 
HETATM 3694 O  O   . HOH H 4 .   ? 28.31684  1.85263   50.04712 1.000 49.22128  ? 471 HOH A O   1 
HETATM 3695 O  O   . HOH H 4 .   ? 10.131    18.311    55.834   1.000 46.53129  ? 472 HOH A O   1 
HETATM 3696 O  O   . HOH H 4 .   ? 31.00368  4.72410   43.52291 1.000 50.33640  ? 473 HOH A O   1 
HETATM 3697 O  O   . HOH H 4 .   ? 7.914     18.193    56.514   1.000 30.12863  ? 474 HOH A O   1 
HETATM 3698 O  O   . HOH H 4 .   ? 31.07790  -5.14472  49.61060 1.000 39.23824  ? 475 HOH A O   1 
HETATM 3699 O  O   . HOH H 4 .   ? 4.32496   23.46324  43.02456 1.000 53.17014  ? 476 HOH A O   1 
HETATM 3700 O  O   . HOH H 4 .   ? 13.67587  1.39796   38.28287 1.000 38.05637  ? 477 HOH A O   1 
HETATM 3701 O  O   . HOH H 4 .   ? 23.68045  -10.27707 59.01018 1.000 49.13662  ? 478 HOH A O   1 
HETATM 3702 O  O   . HOH H 4 .   ? -7.55212  4.69041   44.03641 1.000 58.95142  ? 479 HOH A O   1 
HETATM 3703 O  O   . HOH H 4 .   ? 30.40168  3.20715   47.15960 1.000 46.53896  ? 480 HOH A O   1 
HETATM 3704 O  O   . HOH H 4 .   ? 7.494     18.085    53.584   1.000 58.73130  ? 481 HOH A O   1 
HETATM 3705 O  O   . HOH H 4 .   ? 32.65377  -5.88738  47.54594 1.000 71.50642  ? 482 HOH A O   1 
HETATM 3706 O  O   . HOH H 4 .   ? 4.96618   24.09064  45.00240 1.000 59.60070  ? 483 HOH A O   1 
HETATM 3707 O  O   . HOH I 4 .   ? 36.68817  17.39034  31.84775 1.000 65.74785  ? 401 HOH B O   1 
HETATM 3708 O  O   . HOH I 4 .   ? 26.36504  -10.10520 30.17364 1.000 45.10360  ? 402 HOH B O   1 
HETATM 3709 O  O   . HOH I 4 .   ? 40.64842  17.87712  11.56544 1.000 69.74183  ? 403 HOH B O   1 
HETATM 3710 O  O   . HOH I 4 .   ? 20.54550  -0.79334  21.76059 1.000 47.38587  ? 404 HOH B O   1 
HETATM 3711 O  O   . HOH I 4 .   ? 13.16169  -3.11570  21.70243 1.000 50.16418  ? 405 HOH B O   1 
HETATM 3712 O  O   . HOH I 4 .   ? 18.83060  3.45089   2.74164  1.000 67.85453  ? 406 HOH B O   1 
HETATM 3713 O  O   . HOH I 4 .   ? 20.54685  12.39236  30.97571 1.000 44.18867  ? 407 HOH B O   1 
HETATM 3714 O  O   . HOH I 4 .   ? 41.46185  -2.88413  8.47873  1.000 62.62683  ? 408 HOH B O   1 
HETATM 3715 O  O   . HOH I 4 .   ? 18.52478  6.58858   14.47316 1.000 40.06849  ? 409 HOH B O   1 
HETATM 3716 O  O   . HOH I 4 .   ? 31.25844  7.59866   29.21058 1.000 44.65320  ? 410 HOH B O   1 
HETATM 3717 O  O   . HOH I 4 .   ? 17.92391  -10.62758 21.85280 1.000 53.87542  ? 411 HOH B O   1 
HETATM 3718 O  O   . HOH I 4 .   ? 31.89181  -9.95739  11.44765 1.000 49.53775  ? 412 HOH B O   1 
HETATM 3719 O  O   . HOH I 4 .   ? 27.73904  18.50627  36.76311 1.000 48.92361  ? 413 HOH B O   1 
HETATM 3720 O  O   . HOH I 4 .   ? 43.10812  -1.16747  8.99475  1.000 65.97427  ? 414 HOH B O   1 
HETATM 3721 O  O   . HOH I 4 .   ? 42.24784  19.12377  18.78585 1.000 61.65863  ? 415 HOH B O   1 
HETATM 3722 O  O   . HOH I 4 .   ? 48.83876  25.95555  6.29958  1.000 65.00633  ? 416 HOH B O   1 
HETATM 3723 O  O   . HOH I 4 .   ? 41.59846  7.44013   -2.76085 1.000 51.35052  ? 417 HOH B O   1 
HETATM 3724 O  O   . HOH I 4 .   ? 7.71210   6.75777   18.49216 1.000 53.46635  ? 418 HOH B O   1 
HETATM 3725 O  O   . HOH I 4 .   ? 48.26908  5.39670   20.17782 1.000 67.27378  ? 419 HOH B O   1 
HETATM 3726 O  O   . HOH I 4 .   ? 22.67160  21.73980  19.39529 1.000 57.19260  ? 420 HOH B O   1 
HETATM 3727 O  O   . HOH I 4 .   ? 27.38794  0.96216   29.44216 1.000 44.56798  ? 421 HOH B O   1 
HETATM 3728 O  O   . HOH I 4 .   ? 36.85681  -8.81490  -6.06932 1.000 58.58174  ? 422 HOH B O   1 
HETATM 3729 O  O   . HOH I 4 .   ? 36.68690  3.38909   28.86630 1.000 54.57037  ? 423 HOH B O   1 
HETATM 3730 O  O   . HOH I 4 .   ? 18.67826  16.81805  30.69095 1.000 45.47334  ? 424 HOH B O   1 
HETATM 3731 O  O   . HOH I 4 .   ? 10.69481  7.63287   17.88436 1.000 66.62030  ? 425 HOH B O   1 
HETATM 3732 O  O   . HOH I 4 .   ? 49.31933  7.50403   19.79277 1.000 59.60169  ? 426 HOH B O   1 
HETATM 3733 O  O   . HOH I 4 .   ? 13.33998  16.42920  27.37909 1.000 53.36724  ? 427 HOH B O   1 
HETATM 3734 O  O   . HOH I 4 .   ? 30.66082  0.40840   29.48988 1.000 43.66870  ? 428 HOH B O   1 
HETATM 3735 O  O   . HOH I 4 .   ? 37.83697  18.23624  18.20581 1.000 58.53097  ? 429 HOH B O   1 
HETATM 3736 O  O   . HOH I 4 .   ? 12.56318  5.84447   17.77843 1.000 48.69583  ? 430 HOH B O   1 
HETATM 3737 O  O   . HOH I 4 .   ? 7.18788   6.18770   25.76094 1.000 57.87000  ? 431 HOH B O   1 
HETATM 3738 O  O   . HOH I 4 .   ? 42.54078  5.34790   -3.20423 1.000 74.18741  ? 432 HOH B O   1 
HETATM 3739 O  O   . HOH I 4 .   ? 41.22065  5.54046   -5.04218 1.000 57.17158  ? 433 HOH B O   1 
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