data_9DQP
# 
_entry.id   9DQP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQP         pdb_00009dqp 10.2210/pdb9dqp/pdb 
WWPDB D_1000288599 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQP 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wchang6@ncsu.edu 
_pdbx_contact_author.name_first         Wei-chen 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2341-9846 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, Y.-C.' 1 ? 
'Chang, W.-C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            147 
_citation.language                  ? 
_citation.page_first                6162 
_citation.page_last                 6170 
_citation.title                     
;Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c17741 
_citation.pdbx_database_id_PubMed   39901767 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, Y.C.'   1  ? 
primary 'Li, X.'        2  ? 
primary 'Cha, L.'       3  ? 
primary 'Paris, J.C.'   4  ? 
primary 'Michael, C.'   5  ? 
primary 'Ushimaru, R.'  6  ? 
primary 'Ogasawara, Y.' 7  ? 
primary 'Abe, I.'       8  ? 
primary 'Guo, Y.'       9  ? 
primary 'Chang, W.C.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '2OG-Fe dioxygenase family protein' 29345.768 2   ? ? ? ? 
2 non-polymer syn 'POTASSIUM ION'                     39.098    2   ? ? ? ? 
3 non-polymer syn 'THIOCYANATE ION'                   58.082    2   ? ? ? ? 
4 non-polymer syn GLYCEROL                            92.094    1   ? ? ? ? 
5 water       nat water                               18.015    376 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAAHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'POTASSIUM ION'   K   
3 'THIOCYANATE ION' SCN 
4 GLYCEROL          GOL 
5 water             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLN n 
1 3   THR n 
1 4   GLU n 
1 5   ALA n 
1 6   ARG n 
1 7   GLU n 
1 8   GLU n 
1 9   LEU n 
1 10  ARG n 
1 11  ALA n 
1 12  ASN n 
1 13  GLY n 
1 14  TYR n 
1 15  SER n 
1 16  LEU n 
1 17  LEU n 
1 18  PRO n 
1 19  ALA n 
1 20  ASP n 
1 21  ARG n 
1 22  LEU n 
1 23  VAL n 
1 24  ILE n 
1 25  ASP n 
1 26  ALA n 
1 27  GLU n 
1 28  LEU n 
1 29  ARG n 
1 30  GLN n 
1 31  HIS n 
1 32  VAL n 
1 33  LYS n 
1 34  GLU n 
1 35  LEU n 
1 36  ALA n 
1 37  ALA n 
1 38  GLU n 
1 39  TRP n 
1 40  GLU n 
1 41  ASN n 
1 42  LEU n 
1 43  GLU n 
1 44  THR n 
1 45  ASP n 
1 46  ARG n 
1 47  TYR n 
1 48  LEU n 
1 49  LYS n 
1 50  GLY n 
1 51  GLY n 
1 52  SER n 
1 53  ARG n 
1 54  PHE n 
1 55  ARG n 
1 56  GLU n 
1 57  ARG n 
1 58  ALA n 
1 59  TYR n 
1 60  ASP n 
1 61  ARG n 
1 62  PHE n 
1 63  PHE n 
1 64  PHE n 
1 65  VAL n 
1 66  PRO n 
1 67  ARG n 
1 68  THR n 
1 69  GLY n 
1 70  GLU n 
1 71  VAL n 
1 72  ARG n 
1 73  LEU n 
1 74  ARG n 
1 75  PRO n 
1 76  HIS n 
1 77  ARG n 
1 78  PRO n 
1 79  TYR n 
1 80  PHE n 
1 81  GLN n 
1 82  SER n 
1 83  MET n 
1 84  ASN n 
1 85  ALA n 
1 86  ASN n 
1 87  ASP n 
1 88  TYR n 
1 89  ALA n 
1 90  GLY n 
1 91  GLY n 
1 92  ILE n 
1 93  ASP n 
1 94  ARG n 
1 95  ASP n 
1 96  VAL n 
1 97  ALA n 
1 98  PRO n 
1 99  LEU n 
1 100 SER n 
1 101 ARG n 
1 102 THR n 
1 103 THR n 
1 104 LEU n 
1 105 ALA n 
1 106 ASN n 
1 107 PRO n 
1 108 LEU n 
1 109 LEU n 
1 110 THR n 
1 111 ARG n 
1 112 LEU n 
1 113 LEU n 
1 114 ARG n 
1 115 ALA n 
1 116 ASP n 
1 117 PHE n 
1 118 GLU n 
1 119 ASN n 
1 120 PHE n 
1 121 PRO n 
1 122 VAL n 
1 123 PRO n 
1 124 GLU n 
1 125 GLU n 
1 126 SER n 
1 127 TRP n 
1 128 LEU n 
1 129 ASP n 
1 130 ASP n 
1 131 PRO n 
1 132 TRP n 
1 133 ASP n 
1 134 VAL n 
1 135 GLN n 
1 136 CYS n 
1 137 HIS n 
1 138 GLN n 
1 139 PHE n 
1 140 ARG n 
1 141 ILE n 
1 142 ILE n 
1 143 SER n 
1 144 THR n 
1 145 PRO n 
1 146 ASP n 
1 147 GLU n 
1 148 THR n 
1 149 GLY n 
1 150 GLU n 
1 151 PRO n 
1 152 THR n 
1 153 PRO n 
1 154 GLU n 
1 155 GLY n 
1 156 PRO n 
1 157 HIS n 
1 158 ARG n 
1 159 ASP n 
1 160 GLU n 
1 161 VAL n 
1 162 ASP n 
1 163 PHE n 
1 164 GLY n 
1 165 VAL n 
1 166 ILE n 
1 167 HIS n 
1 168 LEU n 
1 169 MET n 
1 170 GLY n 
1 171 ARG n 
1 172 PHE n 
1 173 ASN n 
1 174 ALA n 
1 175 ALA n 
1 176 GLY n 
1 177 GLY n 
1 178 GLU n 
1 179 SER n 
1 180 GLN n 
1 181 VAL n 
1 182 TYR n 
1 183 SER n 
1 184 LEU n 
1 185 GLU n 
1 186 ARG n 
1 187 GLU n 
1 188 LEU n 
1 189 VAL n 
1 190 ALA n 
1 191 GLU n 
1 192 PHE n 
1 193 CYS n 
1 194 LEU n 
1 195 THR n 
1 196 GLU n 
1 197 GLN n 
1 198 MET n 
1 199 ASP n 
1 200 THR n 
1 201 MET n 
1 202 PHE n 
1 203 TRP n 
1 204 SER n 
1 205 ASP n 
1 206 GLY n 
1 207 GLN n 
1 208 ILE n 
1 209 LEU n 
1 210 HIS n 
1 211 ALA n 
1 212 VAL n 
1 213 ARG n 
1 214 PRO n 
1 215 ILE n 
1 216 HIS n 
1 217 PRO n 
1 218 VAL n 
1 219 ASP n 
1 220 PRO n 
1 221 THR n 
1 222 LYS n 
1 223 ALA n 
1 224 ALA n 
1 225 VAL n 
1 226 ARG n 
1 227 ASP n 
1 228 VAL n 
1 229 LEU n 
1 230 ILE n 
1 231 MET n 
1 232 GLY n 
1 233 TYR n 
1 234 LYS n 
1 235 HIS n 
1 236 GLU n 
1 237 PRO n 
1 238 GLU n 
1 239 LEU n 
1 240 ARG n 
1 241 ARG n 
1 242 GLU n 
1 243 GLU n 
1 244 GLN n 
1 245 GLY n 
1 246 ALA n 
1 247 ALA n 
1 248 HIS n 
1 249 HIS n 
1 250 HIS n 
1 251 HIS n 
1 252 HIS n 
1 253 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   253 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 EDD96_7010 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp. Ag109_G2-6' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2485154 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE          ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE         ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL          'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE         ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ?                               'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION'   ?                               'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE           ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ?                               'C5 H9 N O2'     115.130 
SCN non-polymer         . 'THIOCYANATE ION' ?                               'C N S -1'       58.082  
SER 'L-peptide linking' y SERINE            ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE         ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN        ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE          ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLN 2   2   2   GLN GLN A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ALA 5   5   5   ALA ALA A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   GLU 8   8   8   GLU GLU A . n 
A 1 9   LEU 9   9   9   LEU LEU A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  ASN 12  12  12  ASN ASN A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  ASP 20  20  20  ASP ASP A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  VAL 23  23  23  VAL VAL A . n 
A 1 24  ILE 24  24  24  ILE ALA A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  GLU 27  27  27  GLU GLU A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  HIS 31  31  31  HIS HIS A . n 
A 1 32  VAL 32  32  32  VAL VAL A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  GLU 38  38  38  GLU GLU A . n 
A 1 39  TRP 39  39  39  TRP TRP A . n 
A 1 40  GLU 40  40  40  GLU GLU A . n 
A 1 41  ASN 41  41  41  ASN ASN A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLU 43  43  43  GLU GLU A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  ARG 46  46  ?   ?   ?   A . n 
A 1 47  TYR 47  47  ?   ?   ?   A . n 
A 1 48  LEU 48  48  ?   ?   ?   A . n 
A 1 49  LYS 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  GLY 51  51  ?   ?   ?   A . n 
A 1 52  SER 52  52  ?   ?   ?   A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  ARG 55  55  55  ARG ARG A . n 
A 1 56  GLU 56  56  56  GLU GLU A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  ARG 61  61  61  ARG ARG A . n 
A 1 62  PHE 62  62  62  PHE PHE A . n 
A 1 63  PHE 63  63  63  PHE PHE A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  VAL 71  71  71  VAL VAL A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  LEU 73  73  73  LEU LEU A . n 
A 1 74  ARG 74  74  74  ARG ARG A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  HIS 76  76  76  HIS HIS A . n 
A 1 77  ARG 77  77  77  ARG ARG A . n 
A 1 78  PRO 78  78  78  PRO PRO A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  GLN 81  81  81  GLN GLN A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  MET 83  83  83  MET MET A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  ALA 89  89  89  ALA ALA A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ARG 94  94  94  ARG ARG A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  PRO 98  98  98  PRO PRO A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 ARG 101 101 101 ARG ARG A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 THR 110 110 110 THR THR A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 GLU 118 118 118 GLU GLU A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 PHE 120 120 120 PHE PHE A . n 
A 1 121 PRO 121 121 121 PRO PRO A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 GLU 124 124 124 GLU GLU A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 SER 126 126 126 SER SER A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 PRO 131 131 131 PRO PRO A . n 
A 1 132 TRP 132 132 132 TRP TRP A . n 
A 1 133 ASP 133 133 133 ASP ASP A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 CYS 136 136 136 CYS CYS A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 GLU 147 147 ?   ?   ?   A . n 
A 1 148 THR 148 148 ?   ?   ?   A . n 
A 1 149 GLY 149 149 ?   ?   ?   A . n 
A 1 150 GLU 150 150 ?   ?   ?   A . n 
A 1 151 PRO 151 151 ?   ?   ?   A . n 
A 1 152 THR 152 152 ?   ?   ?   A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 GLY 155 155 155 GLY GLY A . n 
A 1 156 PRO 156 156 156 PRO PRO A . n 
A 1 157 HIS 157 157 157 HIS HIS A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 PHE 163 163 163 PHE PHE A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 MET 169 169 169 MET MET A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 ASN 173 173 173 ASN ASN A . n 
A 1 174 ALA 174 174 174 ALA ALA A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 GLU 187 187 187 GLU GLU A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 GLN 197 197 197 GLN GLN A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 ASP 199 199 199 ASP ASP A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 MET 201 201 201 MET MET A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 TRP 203 203 203 TRP TRP A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 GLN 207 207 207 GLN GLN A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 HIS 210 210 210 HIS HIS A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ARG 213 213 213 ARG ARG A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 HIS 216 216 216 HIS HIS A . n 
A 1 217 PRO 217 217 217 PRO PRO A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 PRO 220 220 220 PRO PRO A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 VAL 225 225 225 VAL VAL A . n 
A 1 226 ARG 226 226 226 ARG ARG A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 ILE 230 230 230 ILE ILE A . n 
A 1 231 MET 231 231 231 MET MET A . n 
A 1 232 GLY 232 232 232 GLY GLY A . n 
A 1 233 TYR 233 233 233 TYR TYR A . n 
A 1 234 LYS 234 234 234 LYS LYS A . n 
A 1 235 HIS 235 235 235 HIS HIS A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 ARG 241 241 241 ARG ARG A . n 
A 1 242 GLU 242 242 242 GLU GLU A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 GLY 245 245 ?   ?   ?   A . n 
A 1 246 ALA 246 246 ?   ?   ?   A . n 
A 1 247 ALA 247 247 ?   ?   ?   A . n 
A 1 248 HIS 248 248 ?   ?   ?   A . n 
A 1 249 HIS 249 249 ?   ?   ?   A . n 
A 1 250 HIS 250 250 ?   ?   ?   A . n 
A 1 251 HIS 251 251 ?   ?   ?   A . n 
A 1 252 HIS 252 252 ?   ?   ?   A . n 
A 1 253 HIS 253 253 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLN 2   2   ?   ?   ?   B . n 
B 1 3   THR 3   3   3   THR THR B . n 
B 1 4   GLU 4   4   4   GLU GLU B . n 
B 1 5   ALA 5   5   5   ALA ALA B . n 
B 1 6   ARG 6   6   6   ARG ARG B . n 
B 1 7   GLU 7   7   7   GLU GLU B . n 
B 1 8   GLU 8   8   8   GLU GLU B . n 
B 1 9   LEU 9   9   9   LEU LEU B . n 
B 1 10  ARG 10  10  10  ARG ARG B . n 
B 1 11  ALA 11  11  11  ALA ALA B . n 
B 1 12  ASN 12  12  12  ASN ASN B . n 
B 1 13  GLY 13  13  13  GLY GLY B . n 
B 1 14  TYR 14  14  14  TYR TYR B . n 
B 1 15  SER 15  15  15  SER SER B . n 
B 1 16  LEU 16  16  16  LEU LEU B . n 
B 1 17  LEU 17  17  17  LEU LEU B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  ALA 19  19  19  ALA ALA B . n 
B 1 20  ASP 20  20  20  ASP ASP B . n 
B 1 21  ARG 21  21  21  ARG ARG B . n 
B 1 22  LEU 22  22  22  LEU LEU B . n 
B 1 23  VAL 23  23  23  VAL VAL B . n 
B 1 24  ILE 24  24  24  ILE ALA B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ALA 26  26  26  ALA ALA B . n 
B 1 27  GLU 27  27  27  GLU GLU B . n 
B 1 28  LEU 28  28  28  LEU LEU B . n 
B 1 29  ARG 29  29  29  ARG ARG B . n 
B 1 30  GLN 30  30  30  GLN GLN B . n 
B 1 31  HIS 31  31  31  HIS HIS B . n 
B 1 32  VAL 32  32  32  VAL VAL B . n 
B 1 33  LYS 33  33  33  LYS LYS B . n 
B 1 34  GLU 34  34  34  GLU GLU B . n 
B 1 35  LEU 35  35  35  LEU LEU B . n 
B 1 36  ALA 36  36  36  ALA ALA B . n 
B 1 37  ALA 37  37  37  ALA ALA B . n 
B 1 38  GLU 38  38  38  GLU GLU B . n 
B 1 39  TRP 39  39  39  TRP TRP B . n 
B 1 40  GLU 40  40  40  GLU GLU B . n 
B 1 41  ASN 41  41  41  ASN ASN B . n 
B 1 42  LEU 42  42  42  LEU LEU B . n 
B 1 43  GLU 43  43  43  GLU GLU B . n 
B 1 44  THR 44  44  44  THR THR B . n 
B 1 45  ASP 45  45  45  ASP ASP B . n 
B 1 46  ARG 46  46  46  ARG ARG B . n 
B 1 47  TYR 47  47  ?   ?   ?   B . n 
B 1 48  LEU 48  48  ?   ?   ?   B . n 
B 1 49  LYS 49  49  ?   ?   ?   B . n 
B 1 50  GLY 50  50  ?   ?   ?   B . n 
B 1 51  GLY 51  51  51  GLY GLY B . n 
B 1 52  SER 52  52  52  SER SER B . n 
B 1 53  ARG 53  53  53  ARG ARG B . n 
B 1 54  PHE 54  54  54  PHE PHE B . n 
B 1 55  ARG 55  55  55  ARG ARG B . n 
B 1 56  GLU 56  56  56  GLU GLU B . n 
B 1 57  ARG 57  57  57  ARG ARG B . n 
B 1 58  ALA 58  58  58  ALA ALA B . n 
B 1 59  TYR 59  59  59  TYR TYR B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  ARG 61  61  61  ARG ARG B . n 
B 1 62  PHE 62  62  62  PHE PHE B . n 
B 1 63  PHE 63  63  63  PHE PHE B . n 
B 1 64  PHE 64  64  64  PHE PHE B . n 
B 1 65  VAL 65  65  65  VAL VAL B . n 
B 1 66  PRO 66  66  66  PRO PRO B . n 
B 1 67  ARG 67  67  67  ARG ARG B . n 
B 1 68  THR 68  68  68  THR THR B . n 
B 1 69  GLY 69  69  69  GLY GLY B . n 
B 1 70  GLU 70  70  70  GLU GLU B . n 
B 1 71  VAL 71  71  71  VAL VAL B . n 
B 1 72  ARG 72  72  72  ARG ARG B . n 
B 1 73  LEU 73  73  73  LEU LEU B . n 
B 1 74  ARG 74  74  74  ARG ARG B . n 
B 1 75  PRO 75  75  75  PRO PRO B . n 
B 1 76  HIS 76  76  76  HIS HIS B . n 
B 1 77  ARG 77  77  77  ARG ARG B . n 
B 1 78  PRO 78  78  78  PRO PRO B . n 
B 1 79  TYR 79  79  79  TYR TYR B . n 
B 1 80  PHE 80  80  80  PHE PHE B . n 
B 1 81  GLN 81  81  ?   ?   ?   B . n 
B 1 82  SER 82  82  ?   ?   ?   B . n 
B 1 83  MET 83  83  ?   ?   ?   B . n 
B 1 84  ASN 84  84  ?   ?   ?   B . n 
B 1 85  ALA 85  85  ?   ?   ?   B . n 
B 1 86  ASN 86  86  ?   ?   ?   B . n 
B 1 87  ASP 87  87  ?   ?   ?   B . n 
B 1 88  TYR 88  88  ?   ?   ?   B . n 
B 1 89  ALA 89  89  ?   ?   ?   B . n 
B 1 90  GLY 90  90  ?   ?   ?   B . n 
B 1 91  GLY 91  91  ?   ?   ?   B . n 
B 1 92  ILE 92  92  ?   ?   ?   B . n 
B 1 93  ASP 93  93  ?   ?   ?   B . n 
B 1 94  ARG 94  94  ?   ?   ?   B . n 
B 1 95  ASP 95  95  95  ASP ASP B . n 
B 1 96  VAL 96  96  96  VAL VAL B . n 
B 1 97  ALA 97  97  97  ALA ALA B . n 
B 1 98  PRO 98  98  98  PRO PRO B . n 
B 1 99  LEU 99  99  99  LEU LEU B . n 
B 1 100 SER 100 100 100 SER SER B . n 
B 1 101 ARG 101 101 101 ARG ARG B . n 
B 1 102 THR 102 102 102 THR THR B . n 
B 1 103 THR 103 103 103 THR THR B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 ALA 105 105 105 ALA ALA B . n 
B 1 106 ASN 106 106 106 ASN ASN B . n 
B 1 107 PRO 107 107 107 PRO PRO B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 LEU 109 109 109 LEU LEU B . n 
B 1 110 THR 110 110 110 THR THR B . n 
B 1 111 ARG 111 111 111 ARG ARG B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 LEU 113 113 113 LEU LEU B . n 
B 1 114 ARG 114 114 114 ARG ARG B . n 
B 1 115 ALA 115 115 115 ALA ALA B . n 
B 1 116 ASP 116 116 116 ASP ASP B . n 
B 1 117 PHE 117 117 117 PHE PHE B . n 
B 1 118 GLU 118 118 118 GLU GLU B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 PHE 120 120 120 PHE PHE B . n 
B 1 121 PRO 121 121 121 PRO PRO B . n 
B 1 122 VAL 122 122 122 VAL VAL B . n 
B 1 123 PRO 123 123 123 PRO PRO B . n 
B 1 124 GLU 124 124 124 GLU GLU B . n 
B 1 125 GLU 125 125 125 GLU GLU B . n 
B 1 126 SER 126 126 126 SER SER B . n 
B 1 127 TRP 127 127 127 TRP TRP B . n 
B 1 128 LEU 128 128 128 LEU LEU B . n 
B 1 129 ASP 129 129 129 ASP ASP B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 PRO 131 131 131 PRO PRO B . n 
B 1 132 TRP 132 132 132 TRP TRP B . n 
B 1 133 ASP 133 133 133 ASP ASP B . n 
B 1 134 VAL 134 134 134 VAL VAL B . n 
B 1 135 GLN 135 135 135 GLN GLN B . n 
B 1 136 CYS 136 136 136 CYS CYS B . n 
B 1 137 HIS 137 137 137 HIS HIS B . n 
B 1 138 GLN 138 138 138 GLN GLN B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 ARG 140 140 140 ARG ARG B . n 
B 1 141 ILE 141 141 141 ILE ILE B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 SER 143 143 143 SER SER B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 PRO 145 145 145 PRO PRO B . n 
B 1 146 ASP 146 146 146 ASP ASP B . n 
B 1 147 GLU 147 147 147 GLU GLU B . n 
B 1 148 THR 148 148 ?   ?   ?   B . n 
B 1 149 GLY 149 149 ?   ?   ?   B . n 
B 1 150 GLU 150 150 ?   ?   ?   B . n 
B 1 151 PRO 151 151 151 PRO PRO B . n 
B 1 152 THR 152 152 152 THR THR B . n 
B 1 153 PRO 153 153 153 PRO PRO B . n 
B 1 154 GLU 154 154 154 GLU GLU B . n 
B 1 155 GLY 155 155 155 GLY GLY B . n 
B 1 156 PRO 156 156 156 PRO PRO B . n 
B 1 157 HIS 157 157 157 HIS HIS B . n 
B 1 158 ARG 158 158 158 ARG ARG B . n 
B 1 159 ASP 159 159 159 ASP ASP B . n 
B 1 160 GLU 160 160 160 GLU GLU B . n 
B 1 161 VAL 161 161 161 VAL VAL B . n 
B 1 162 ASP 162 162 162 ASP ASP B . n 
B 1 163 PHE 163 163 163 PHE PHE B . n 
B 1 164 GLY 164 164 164 GLY GLY B . n 
B 1 165 VAL 165 165 165 VAL VAL B . n 
B 1 166 ILE 166 166 166 ILE ILE B . n 
B 1 167 HIS 167 167 167 HIS HIS B . n 
B 1 168 LEU 168 168 168 LEU LEU B . n 
B 1 169 MET 169 169 169 MET MET B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 ARG 171 171 171 ARG ARG B . n 
B 1 172 PHE 172 172 172 PHE PHE B . n 
B 1 173 ASN 173 173 173 ASN ASN B . n 
B 1 174 ALA 174 174 174 ALA ALA B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 GLY 176 176 176 GLY GLY B . n 
B 1 177 GLY 177 177 177 GLY GLY B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 SER 179 179 179 SER SER B . n 
B 1 180 GLN 180 180 180 GLN GLN B . n 
B 1 181 VAL 181 181 181 VAL VAL B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 SER 183 183 183 SER SER B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 ARG 186 186 186 ARG ARG B . n 
B 1 187 GLU 187 187 187 GLU GLU B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 VAL 189 189 189 VAL VAL B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 GLU 191 191 191 GLU GLU B . n 
B 1 192 PHE 192 192 192 PHE PHE B . n 
B 1 193 CYS 193 193 193 CYS CYS B . n 
B 1 194 LEU 194 194 194 LEU LEU B . n 
B 1 195 THR 195 195 195 THR THR B . n 
B 1 196 GLU 196 196 196 GLU GLU B . n 
B 1 197 GLN 197 197 197 GLN GLN B . n 
B 1 198 MET 198 198 198 MET MET B . n 
B 1 199 ASP 199 199 199 ASP ASP B . n 
B 1 200 THR 200 200 200 THR THR B . n 
B 1 201 MET 201 201 201 MET MET B . n 
B 1 202 PHE 202 202 202 PHE PHE B . n 
B 1 203 TRP 203 203 203 TRP TRP B . n 
B 1 204 SER 204 204 204 SER SER B . n 
B 1 205 ASP 205 205 205 ASP ASP B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 GLN 207 207 207 GLN GLN B . n 
B 1 208 ILE 208 208 208 ILE ILE B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 HIS 210 210 210 HIS HIS B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ARG 213 213 213 ARG ARG B . n 
B 1 214 PRO 214 214 214 PRO PRO B . n 
B 1 215 ILE 215 215 215 ILE ILE B . n 
B 1 216 HIS 216 216 216 HIS HIS B . n 
B 1 217 PRO 217 217 217 PRO PRO B . n 
B 1 218 VAL 218 218 218 VAL VAL B . n 
B 1 219 ASP 219 219 219 ASP ASP B . n 
B 1 220 PRO 220 220 220 PRO PRO B . n 
B 1 221 THR 221 221 221 THR THR B . n 
B 1 222 LYS 222 222 222 LYS LYS B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 VAL 225 225 225 VAL VAL B . n 
B 1 226 ARG 226 226 226 ARG ARG B . n 
B 1 227 ASP 227 227 227 ASP ASP B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 ILE 230 230 230 ILE ILE B . n 
B 1 231 MET 231 231 231 MET MET B . n 
B 1 232 GLY 232 232 232 GLY GLY B . n 
B 1 233 TYR 233 233 233 TYR TYR B . n 
B 1 234 LYS 234 234 234 LYS LYS B . n 
B 1 235 HIS 235 235 235 HIS HIS B . n 
B 1 236 GLU 236 236 236 GLU GLU B . n 
B 1 237 PRO 237 237 237 PRO PRO B . n 
B 1 238 GLU 238 238 238 GLU GLU B . n 
B 1 239 LEU 239 239 239 LEU LEU B . n 
B 1 240 ARG 240 240 240 ARG ARG B . n 
B 1 241 ARG 241 241 241 ARG ARG B . n 
B 1 242 GLU 242 242 242 GLU GLU B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLN 244 244 ?   ?   ?   B . n 
B 1 245 GLY 245 245 ?   ?   ?   B . n 
B 1 246 ALA 246 246 ?   ?   ?   B . n 
B 1 247 ALA 247 247 ?   ?   ?   B . n 
B 1 248 HIS 248 248 ?   ?   ?   B . n 
B 1 249 HIS 249 249 ?   ?   ?   B . n 
B 1 250 HIS 250 250 ?   ?   ?   B . n 
B 1 251 HIS 251 251 ?   ?   ?   B . n 
B 1 252 HIS 252 252 ?   ?   ?   B . n 
B 1 253 HIS 253 253 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 K   1   301 301 K   K   A . 
D 3 SCN 1   301 301 SCN SCN B . 
E 3 SCN 1   302 302 SCN SCN B . 
F 2 K   1   303 303 K   K   B . 
G 4 GOL 1   304 304 GOL GOL B . 
H 5 HOH 1   401 627 HOH HOH A . 
H 5 HOH 2   402 11  HOH HOH A . 
H 5 HOH 3   403 246 HOH HOH A . 
H 5 HOH 4   404 222 HOH HOH A . 
H 5 HOH 5   405 187 HOH HOH A . 
H 5 HOH 6   406 178 HOH HOH A . 
H 5 HOH 7   407 789 HOH HOH A . 
H 5 HOH 8   408 144 HOH HOH A . 
H 5 HOH 9   409 269 HOH HOH A . 
H 5 HOH 10  410 57  HOH HOH A . 
H 5 HOH 11  411 567 HOH HOH A . 
H 5 HOH 12  412 646 HOH HOH A . 
H 5 HOH 13  413 267 HOH HOH A . 
H 5 HOH 14  414 140 HOH HOH A . 
H 5 HOH 15  415 177 HOH HOH A . 
H 5 HOH 16  416 727 HOH HOH A . 
H 5 HOH 17  417 41  HOH HOH A . 
H 5 HOH 18  418 242 HOH HOH A . 
H 5 HOH 19  419 163 HOH HOH A . 
H 5 HOH 20  420 4   HOH HOH A . 
H 5 HOH 21  421 38  HOH HOH A . 
H 5 HOH 22  422 15  HOH HOH A . 
H 5 HOH 23  423 806 HOH HOH A . 
H 5 HOH 24  424 31  HOH HOH A . 
H 5 HOH 25  425 94  HOH HOH A . 
H 5 HOH 26  426 224 HOH HOH A . 
H 5 HOH 27  427 95  HOH HOH A . 
H 5 HOH 28  428 157 HOH HOH A . 
H 5 HOH 29  429 220 HOH HOH A . 
H 5 HOH 30  430 97  HOH HOH A . 
H 5 HOH 31  431 118 HOH HOH A . 
H 5 HOH 32  432 201 HOH HOH A . 
H 5 HOH 33  433 24  HOH HOH A . 
H 5 HOH 34  434 63  HOH HOH A . 
H 5 HOH 35  435 8   HOH HOH A . 
H 5 HOH 36  436 323 HOH HOH A . 
H 5 HOH 37  437 34  HOH HOH A . 
H 5 HOH 38  438 135 HOH HOH A . 
H 5 HOH 39  439 28  HOH HOH A . 
H 5 HOH 40  440 7   HOH HOH A . 
H 5 HOH 41  441 19  HOH HOH A . 
H 5 HOH 42  442 198 HOH HOH A . 
H 5 HOH 43  443 150 HOH HOH A . 
H 5 HOH 44  444 16  HOH HOH A . 
H 5 HOH 45  445 37  HOH HOH A . 
H 5 HOH 46  446 379 HOH HOH A . 
H 5 HOH 47  447 48  HOH HOH A . 
H 5 HOH 48  448 70  HOH HOH A . 
H 5 HOH 49  449 315 HOH HOH A . 
H 5 HOH 50  450 231 HOH HOH A . 
H 5 HOH 51  451 66  HOH HOH A . 
H 5 HOH 52  452 25  HOH HOH A . 
H 5 HOH 53  453 91  HOH HOH A . 
H 5 HOH 54  454 100 HOH HOH A . 
H 5 HOH 55  455 98  HOH HOH A . 
H 5 HOH 56  456 127 HOH HOH A . 
H 5 HOH 57  457 44  HOH HOH A . 
H 5 HOH 58  458 65  HOH HOH A . 
H 5 HOH 59  459 247 HOH HOH A . 
H 5 HOH 60  460 10  HOH HOH A . 
H 5 HOH 61  461 259 HOH HOH A . 
H 5 HOH 62  462 35  HOH HOH A . 
H 5 HOH 63  463 69  HOH HOH A . 
H 5 HOH 64  464 193 HOH HOH A . 
H 5 HOH 65  465 194 HOH HOH A . 
H 5 HOH 66  466 47  HOH HOH A . 
H 5 HOH 67  467 5   HOH HOH A . 
H 5 HOH 68  468 82  HOH HOH A . 
H 5 HOH 69  469 27  HOH HOH A . 
H 5 HOH 70  470 30  HOH HOH A . 
H 5 HOH 71  471 226 HOH HOH A . 
H 5 HOH 72  472 33  HOH HOH A . 
H 5 HOH 73  473 99  HOH HOH A . 
H 5 HOH 74  474 195 HOH HOH A . 
H 5 HOH 75  475 56  HOH HOH A . 
H 5 HOH 76  476 154 HOH HOH A . 
H 5 HOH 77  477 307 HOH HOH A . 
H 5 HOH 78  478 907 HOH HOH A . 
H 5 HOH 79  479 117 HOH HOH A . 
H 5 HOH 80  480 29  HOH HOH A . 
H 5 HOH 81  481 129 HOH HOH A . 
H 5 HOH 82  482 348 HOH HOH A . 
H 5 HOH 83  483 133 HOH HOH A . 
H 5 HOH 84  484 40  HOH HOH A . 
H 5 HOH 85  485 39  HOH HOH A . 
H 5 HOH 86  486 271 HOH HOH A . 
H 5 HOH 87  487 268 HOH HOH A . 
H 5 HOH 88  488 96  HOH HOH A . 
H 5 HOH 89  489 225 HOH HOH A . 
H 5 HOH 90  490 18  HOH HOH A . 
H 5 HOH 91  491 912 HOH HOH A . 
H 5 HOH 92  492 32  HOH HOH A . 
H 5 HOH 93  493 232 HOH HOH A . 
H 5 HOH 94  494 331 HOH HOH A . 
H 5 HOH 95  495 217 HOH HOH A . 
H 5 HOH 96  496 230 HOH HOH A . 
H 5 HOH 97  497 110 HOH HOH A . 
H 5 HOH 98  498 51  HOH HOH A . 
H 5 HOH 99  499 197 HOH HOH A . 
H 5 HOH 100 500 80  HOH HOH A . 
H 5 HOH 101 501 36  HOH HOH A . 
H 5 HOH 102 502 103 HOH HOH A . 
H 5 HOH 103 503 106 HOH HOH A . 
H 5 HOH 104 504 508 HOH HOH A . 
H 5 HOH 105 505 92  HOH HOH A . 
H 5 HOH 106 506 159 HOH HOH A . 
H 5 HOH 107 507 26  HOH HOH A . 
H 5 HOH 108 508 64  HOH HOH A . 
H 5 HOH 109 509 256 HOH HOH A . 
H 5 HOH 110 510 20  HOH HOH A . 
H 5 HOH 111 511 190 HOH HOH A . 
H 5 HOH 112 512 160 HOH HOH A . 
H 5 HOH 113 513 169 HOH HOH A . 
H 5 HOH 114 514 523 HOH HOH A . 
H 5 HOH 115 515 79  HOH HOH A . 
H 5 HOH 116 516 170 HOH HOH A . 
H 5 HOH 117 517 128 HOH HOH A . 
H 5 HOH 118 518 2   HOH HOH A . 
H 5 HOH 119 519 254 HOH HOH A . 
H 5 HOH 120 520 126 HOH HOH A . 
H 5 HOH 121 521 112 HOH HOH A . 
H 5 HOH 122 522 701 HOH HOH A . 
H 5 HOH 123 523 136 HOH HOH A . 
H 5 HOH 124 524 137 HOH HOH A . 
H 5 HOH 125 525 499 HOH HOH A . 
H 5 HOH 126 526 279 HOH HOH A . 
H 5 HOH 127 527 102 HOH HOH A . 
H 5 HOH 128 528 179 HOH HOH A . 
H 5 HOH 129 529 218 HOH HOH A . 
H 5 HOH 130 530 71  HOH HOH A . 
H 5 HOH 131 531 42  HOH HOH A . 
H 5 HOH 132 532 537 HOH HOH A . 
H 5 HOH 133 533 138 HOH HOH A . 
H 5 HOH 134 534 416 HOH HOH A . 
H 5 HOH 135 535 55  HOH HOH A . 
H 5 HOH 136 536 622 HOH HOH A . 
H 5 HOH 137 537 84  HOH HOH A . 
H 5 HOH 138 538 270 HOH HOH A . 
H 5 HOH 139 539 121 HOH HOH A . 
H 5 HOH 140 540 85  HOH HOH A . 
H 5 HOH 141 541 287 HOH HOH A . 
H 5 HOH 142 542 399 HOH HOH A . 
H 5 HOH 143 543 821 HOH HOH A . 
H 5 HOH 144 544 292 HOH HOH A . 
H 5 HOH 145 545 275 HOH HOH A . 
H 5 HOH 146 546 123 HOH HOH A . 
H 5 HOH 147 547 325 HOH HOH A . 
H 5 HOH 148 548 248 HOH HOH A . 
H 5 HOH 149 549 731 HOH HOH A . 
H 5 HOH 150 550 550 HOH HOH A . 
H 5 HOH 151 551 799 HOH HOH A . 
H 5 HOH 152 552 284 HOH HOH A . 
H 5 HOH 153 553 299 HOH HOH A . 
H 5 HOH 154 554 239 HOH HOH A . 
H 5 HOH 155 555 288 HOH HOH A . 
H 5 HOH 156 556 235 HOH HOH A . 
H 5 HOH 157 557 122 HOH HOH A . 
H 5 HOH 158 558 313 HOH HOH A . 
H 5 HOH 159 559 910 HOH HOH A . 
H 5 HOH 160 560 532 HOH HOH A . 
H 5 HOH 161 561 283 HOH HOH A . 
H 5 HOH 162 562 172 HOH HOH A . 
H 5 HOH 163 563 618 HOH HOH A . 
H 5 HOH 164 564 61  HOH HOH A . 
H 5 HOH 165 565 273 HOH HOH A . 
H 5 HOH 166 566 153 HOH HOH A . 
H 5 HOH 167 567 496 HOH HOH A . 
H 5 HOH 168 568 310 HOH HOH A . 
H 5 HOH 169 569 211 HOH HOH A . 
H 5 HOH 170 570 317 HOH HOH A . 
H 5 HOH 171 571 181 HOH HOH A . 
H 5 HOH 172 572 824 HOH HOH A . 
H 5 HOH 173 573 206 HOH HOH A . 
H 5 HOH 174 574 649 HOH HOH A . 
H 5 HOH 175 575 162 HOH HOH A . 
H 5 HOH 176 576 182 HOH HOH A . 
H 5 HOH 177 577 243 HOH HOH A . 
H 5 HOH 178 578 176 HOH HOH A . 
H 5 HOH 179 579 134 HOH HOH A . 
H 5 HOH 180 580 807 HOH HOH A . 
H 5 HOH 181 581 81  HOH HOH A . 
H 5 HOH 182 582 266 HOH HOH A . 
H 5 HOH 183 583 759 HOH HOH A . 
H 5 HOH 184 584 125 HOH HOH A . 
H 5 HOH 185 585 297 HOH HOH A . 
H 5 HOH 186 586 188 HOH HOH A . 
H 5 HOH 187 587 199 HOH HOH A . 
H 5 HOH 188 588 185 HOH HOH A . 
H 5 HOH 189 589 301 HOH HOH A . 
H 5 HOH 190 590 186 HOH HOH A . 
H 5 HOH 191 591 236 HOH HOH A . 
H 5 HOH 192 592 600 HOH HOH A . 
H 5 HOH 193 593 742 HOH HOH A . 
H 5 HOH 194 594 336 HOH HOH A . 
H 5 HOH 195 595 83  HOH HOH A . 
H 5 HOH 196 596 241 HOH HOH A . 
H 5 HOH 197 597 252 HOH HOH A . 
H 5 HOH 198 598 699 HOH HOH A . 
H 5 HOH 199 599 282 HOH HOH A . 
H 5 HOH 200 600 720 HOH HOH A . 
H 5 HOH 201 601 255 HOH HOH A . 
H 5 HOH 202 602 746 HOH HOH A . 
H 5 HOH 203 603 756 HOH HOH A . 
H 5 HOH 204 604 905 HOH HOH A . 
H 5 HOH 205 605 608 HOH HOH A . 
H 5 HOH 206 606 250 HOH HOH A . 
H 5 HOH 207 607 713 HOH HOH A . 
H 5 HOH 208 608 420 HOH HOH A . 
I 5 HOH 1   401 238 HOH HOH B . 
I 5 HOH 2   402 78  HOH HOH B . 
I 5 HOH 3   403 304 HOH HOH B . 
I 5 HOH 4   404 411 HOH HOH B . 
I 5 HOH 5   405 354 HOH HOH B . 
I 5 HOH 6   406 885 HOH HOH B . 
I 5 HOH 7   407 781 HOH HOH B . 
I 5 HOH 8   408 359 HOH HOH B . 
I 5 HOH 9   409 151 HOH HOH B . 
I 5 HOH 10  410 155 HOH HOH B . 
I 5 HOH 11  411 108 HOH HOH B . 
I 5 HOH 12  412 264 HOH HOH B . 
I 5 HOH 13  413 295 HOH HOH B . 
I 5 HOH 14  414 636 HOH HOH B . 
I 5 HOH 15  415 321 HOH HOH B . 
I 5 HOH 16  416 223 HOH HOH B . 
I 5 HOH 17  417 668 HOH HOH B . 
I 5 HOH 18  418 504 HOH HOH B . 
I 5 HOH 19  419 214 HOH HOH B . 
I 5 HOH 20  420 265 HOH HOH B . 
I 5 HOH 21  421 111 HOH HOH B . 
I 5 HOH 22  422 143 HOH HOH B . 
I 5 HOH 23  423 12  HOH HOH B . 
I 5 HOH 24  424 174 HOH HOH B . 
I 5 HOH 25  425 305 HOH HOH B . 
I 5 HOH 26  426 758 HOH HOH B . 
I 5 HOH 27  427 219 HOH HOH B . 
I 5 HOH 28  428 322 HOH HOH B . 
I 5 HOH 29  429 49  HOH HOH B . 
I 5 HOH 30  430 156 HOH HOH B . 
I 5 HOH 31  431 90  HOH HOH B . 
I 5 HOH 32  432 244 HOH HOH B . 
I 5 HOH 33  433 9   HOH HOH B . 
I 5 HOH 34  434 189 HOH HOH B . 
I 5 HOH 35  435 212 HOH HOH B . 
I 5 HOH 36  436 658 HOH HOH B . 
I 5 HOH 37  437 53  HOH HOH B . 
I 5 HOH 38  438 21  HOH HOH B . 
I 5 HOH 39  439 116 HOH HOH B . 
I 5 HOH 40  440 3   HOH HOH B . 
I 5 HOH 41  441 152 HOH HOH B . 
I 5 HOH 42  442 43  HOH HOH B . 
I 5 HOH 43  443 175 HOH HOH B . 
I 5 HOH 44  444 141 HOH HOH B . 
I 5 HOH 45  445 213 HOH HOH B . 
I 5 HOH 46  446 208 HOH HOH B . 
I 5 HOH 47  447 148 HOH HOH B . 
I 5 HOH 48  448 54  HOH HOH B . 
I 5 HOH 49  449 22  HOH HOH B . 
I 5 HOH 50  450 114 HOH HOH B . 
I 5 HOH 51  451 180 HOH HOH B . 
I 5 HOH 52  452 88  HOH HOH B . 
I 5 HOH 53  453 14  HOH HOH B . 
I 5 HOH 54  454 77  HOH HOH B . 
I 5 HOH 55  455 13  HOH HOH B . 
I 5 HOH 56  456 340 HOH HOH B . 
I 5 HOH 57  457 93  HOH HOH B . 
I 5 HOH 58  458 74  HOH HOH B . 
I 5 HOH 59  459 87  HOH HOH B . 
I 5 HOH 60  460 101 HOH HOH B . 
I 5 HOH 61  461 477 HOH HOH B . 
I 5 HOH 62  462 104 HOH HOH B . 
I 5 HOH 63  463 107 HOH HOH B . 
I 5 HOH 64  464 45  HOH HOH B . 
I 5 HOH 65  465 72  HOH HOH B . 
I 5 HOH 66  466 196 HOH HOH B . 
I 5 HOH 67  467 191 HOH HOH B . 
I 5 HOH 68  468 318 HOH HOH B . 
I 5 HOH 69  469 145 HOH HOH B . 
I 5 HOH 70  470 6   HOH HOH B . 
I 5 HOH 71  471 124 HOH HOH B . 
I 5 HOH 72  472 68  HOH HOH B . 
I 5 HOH 73  473 258 HOH HOH B . 
I 5 HOH 74  474 368 HOH HOH B . 
I 5 HOH 75  475 60  HOH HOH B . 
I 5 HOH 76  476 17  HOH HOH B . 
I 5 HOH 77  477 109 HOH HOH B . 
I 5 HOH 78  478 237 HOH HOH B . 
I 5 HOH 79  479 161 HOH HOH B . 
I 5 HOH 80  480 173 HOH HOH B . 
I 5 HOH 81  481 146 HOH HOH B . 
I 5 HOH 82  482 293 HOH HOH B . 
I 5 HOH 83  483 73  HOH HOH B . 
I 5 HOH 84  484 86  HOH HOH B . 
I 5 HOH 85  485 637 HOH HOH B . 
I 5 HOH 86  486 167 HOH HOH B . 
I 5 HOH 87  487 205 HOH HOH B . 
I 5 HOH 88  488 334 HOH HOH B . 
I 5 HOH 89  489 164 HOH HOH B . 
I 5 HOH 90  490 158 HOH HOH B . 
I 5 HOH 91  491 62  HOH HOH B . 
I 5 HOH 92  492 327 HOH HOH B . 
I 5 HOH 93  493 263 HOH HOH B . 
I 5 HOH 94  494 262 HOH HOH B . 
I 5 HOH 95  495 147 HOH HOH B . 
I 5 HOH 96  496 166 HOH HOH B . 
I 5 HOH 97  497 67  HOH HOH B . 
I 5 HOH 98  498 76  HOH HOH B . 
I 5 HOH 99  499 139 HOH HOH B . 
I 5 HOH 100 500 890 HOH HOH B . 
I 5 HOH 101 501 524 HOH HOH B . 
I 5 HOH 102 502 50  HOH HOH B . 
I 5 HOH 103 503 215 HOH HOH B . 
I 5 HOH 104 504 113 HOH HOH B . 
I 5 HOH 105 505 229 HOH HOH B . 
I 5 HOH 106 506 210 HOH HOH B . 
I 5 HOH 107 507 580 HOH HOH B . 
I 5 HOH 108 508 130 HOH HOH B . 
I 5 HOH 109 509 671 HOH HOH B . 
I 5 HOH 110 510 75  HOH HOH B . 
I 5 HOH 111 511 184 HOH HOH B . 
I 5 HOH 112 512 253 HOH HOH B . 
I 5 HOH 113 513 52  HOH HOH B . 
I 5 HOH 114 514 762 HOH HOH B . 
I 5 HOH 115 515 520 HOH HOH B . 
I 5 HOH 116 516 23  HOH HOH B . 
I 5 HOH 117 517 131 HOH HOH B . 
I 5 HOH 118 518 192 HOH HOH B . 
I 5 HOH 119 519 452 HOH HOH B . 
I 5 HOH 120 520 519 HOH HOH B . 
I 5 HOH 121 521 202 HOH HOH B . 
I 5 HOH 122 522 59  HOH HOH B . 
I 5 HOH 123 523 568 HOH HOH B . 
I 5 HOH 124 524 142 HOH HOH B . 
I 5 HOH 125 525 227 HOH HOH B . 
I 5 HOH 126 526 58  HOH HOH B . 
I 5 HOH 127 527 314 HOH HOH B . 
I 5 HOH 128 528 234 HOH HOH B . 
I 5 HOH 129 529 1   HOH HOH B . 
I 5 HOH 130 530 115 HOH HOH B . 
I 5 HOH 131 531 689 HOH HOH B . 
I 5 HOH 132 532 285 HOH HOH B . 
I 5 HOH 133 533 298 HOH HOH B . 
I 5 HOH 134 534 233 HOH HOH B . 
I 5 HOH 135 535 772 HOH HOH B . 
I 5 HOH 136 536 457 HOH HOH B . 
I 5 HOH 137 537 165 HOH HOH B . 
I 5 HOH 138 538 601 HOH HOH B . 
I 5 HOH 139 539 289 HOH HOH B . 
I 5 HOH 140 540 482 HOH HOH B . 
I 5 HOH 141 541 351 HOH HOH B . 
I 5 HOH 142 542 149 HOH HOH B . 
I 5 HOH 143 543 209 HOH HOH B . 
I 5 HOH 144 544 274 HOH HOH B . 
I 5 HOH 145 545 278 HOH HOH B . 
I 5 HOH 146 546 46  HOH HOH B . 
I 5 HOH 147 547 581 HOH HOH B . 
I 5 HOH 148 548 200 HOH HOH B . 
I 5 HOH 149 549 119 HOH HOH B . 
I 5 HOH 150 550 775 HOH HOH B . 
I 5 HOH 151 551 544 HOH HOH B . 
I 5 HOH 152 552 461 HOH HOH B . 
I 5 HOH 153 553 286 HOH HOH B . 
I 5 HOH 154 554 431 HOH HOH B . 
I 5 HOH 155 555 228 HOH HOH B . 
I 5 HOH 156 556 183 HOH HOH B . 
I 5 HOH 157 557 120 HOH HOH B . 
I 5 HOH 158 558 89  HOH HOH B . 
I 5 HOH 159 559 308 HOH HOH B . 
I 5 HOH 160 560 281 HOH HOH B . 
I 5 HOH 161 561 168 HOH HOH B . 
I 5 HOH 162 562 216 HOH HOH B . 
I 5 HOH 163 563 424 HOH HOH B . 
I 5 HOH 164 564 845 HOH HOH B . 
I 5 HOH 165 565 105 HOH HOH B . 
I 5 HOH 166 566 426 HOH HOH B . 
I 5 HOH 167 567 171 HOH HOH B . 
I 5 HOH 168 568 481 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ILE 24 ? CG1 ? A ILE 24 CG1 
2 1 Y 1 A ILE 24 ? CG2 ? A ILE 24 CG2 
3 1 Y 1 A ILE 24 ? CD1 ? A ILE 24 CD1 
4 1 Y 1 B ILE 24 ? CG1 ? B ILE 24 CG1 
5 1 Y 1 B ILE 24 ? CG2 ? B ILE 24 CG2 
6 1 Y 1 B ILE 24 ? CD1 ? B ILE 24 CD1 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .    4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   107.026 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     97.052 
_cell.length_a_esd                 ? 
_cell.length_b                     42.931 
_cell.length_b_esd                 ? 
_cell.length_c                     126.758 
_cell.length_c_esd                 ? 
_cell.volume                       504994.778 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.82 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.176 M KSCN, 20.8% (w/v) PEG 3350, 20 mM KCl' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-06-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97946 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97946 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          17.64 
_reflns.entry_id                                       9DQP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.95 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     35459 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.991 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.084 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.95 
_reflns_shell.d_res_low                                     1.98 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1751 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.901 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.2 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.28 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             38.96 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     32660 
_refine.ls_number_reflns_R_free                  1626 
_refine.ls_number_reflns_R_work                  31034 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    88.79 
_refine.ls_percent_reflns_R_free                 4.98 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2007 
_refine.ls_R_factor_R_free                       0.2514 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1981 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.5079 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2203 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        38.96 
_refine_hist.number_atoms_solvent             376 
_refine_hist.number_atoms_total               4084 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3694 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         14 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0073  ? 3849 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9057  ? 5219 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0594  ? 542  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0094  ? 705  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.8157 ? 1462 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 2.01  . . 79  1539 53.99 . . . . 0.2529 . . . . . . . . . . . 0.3498 
'X-RAY DIFFRACTION' 2.01 2.07  . . 89  2025 69.40 . . . . 0.2454 . . . . . . . . . . . 0.2845 
'X-RAY DIFFRACTION' 2.07 2.15  . . 117 2202 76.01 . . . . 0.2390 . . . . . . . . . . . 0.2990 
'X-RAY DIFFRACTION' 2.15 2.23  . . 155 2723 94.95 . . . . 0.2184 . . . . . . . . . . . 0.2731 
'X-RAY DIFFRACTION' 2.23 2.34  . . 162 2816 98.28 . . . . 0.2092 . . . . . . . . . . . 0.2953 
'X-RAY DIFFRACTION' 2.34 2.46  . . 153 2837 97.84 . . . . 0.2202 . . . . . . . . . . . 0.2771 
'X-RAY DIFFRACTION' 2.46 2.61  . . 151 2827 97.58 . . . . 0.2156 . . . . . . . . . . . 0.3109 
'X-RAY DIFFRACTION' 2.61 2.81  . . 150 2801 96.03 . . . . 0.2136 . . . . . . . . . . . 0.2722 
'X-RAY DIFFRACTION' 2.81 3.10  . . 137 2675 91.21 . . . . 0.2053 . . . . . . . . . . . 0.2434 
'X-RAY DIFFRACTION' 3.10 3.54  . . 154 2806 96.26 . . . . 0.1908 . . . . . . . . . . . 0.2360 
'X-RAY DIFFRACTION' 3.55 4.46  . . 146 2863 97.50 . . . . 0.1550 . . . . . . . . . . . 0.1921 
'X-RAY DIFFRACTION' 4.47 38.96 . . 133 2920 95.41 . . . . 0.1823 . . . . . . . . . . . 0.2263 
# 
_struct.entry_id                     9DQP 
_struct.title                        'Crystal structure of apo-HrmJ from Streptomyces sp. Ag109_G2-6 (HrmJ-ssa)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQP 
_struct_keywords.text            'hydroxylase, non-heme iron 2OG enzyme, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 2 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A3N4ZHX0_9ACTN 
_struct_ref.pdbx_db_accession          A0A3N4ZHX0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MQTEAREELRANGYSLLPADRLVIDAELRQHVKELAAEWENLETDRYLKGGSRFRERAYDRFFFVPRTGEVRLRPHRPYF
QSMNANDYAGGIDRDVAPLSRTTLANPLLTRLLRADFENFPVPEESWLDDPWDVQCHQFRIISTPDETGEPTPEGPHRDE
VDFGVIHLMGRFNAAGGESQVYSLERELVAEFCLTEQMDTMFWSDGQILHAVRPIHPVDPTKAAVRDVLIMGYKHEPELR
REEQGAA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQP A 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
2 1 9DQP B 1 ? 247 ? A0A3N4ZHX0 1 ? 247 ? 1 247 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQP HIS A 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 1  
1 9DQP HIS A 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 2  
1 9DQP HIS A 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 3  
1 9DQP HIS A 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 4  
1 9DQP HIS A 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 5  
1 9DQP HIS A 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 6  
2 9DQP HIS B 248 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 248 7  
2 9DQP HIS B 249 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 249 8  
2 9DQP HIS B 250 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 250 9  
2 9DQP HIS B 251 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 251 10 
2 9DQP HIS B 252 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 252 11 
2 9DQP HIS B 253 ? UNP A0A3N4ZHX0 ? ? 'expression tag' 253 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 2   ? GLY A 13  ? GLN A 2   GLY A 13  1 ? 12 
HELX_P HELX_P2  AA2 ASP A 25  ? GLU A 38  ? ASP A 25  GLU A 38  1 ? 14 
HELX_P HELX_P3  AA3 TRP A 39  ? LEU A 42  ? TRP A 39  LEU A 42  5 ? 4  
HELX_P HELX_P4  AA4 PRO A 78  ? ASN A 86  ? PRO A 78  ASN A 86  1 ? 9  
HELX_P HELX_P5  AA5 SER A 100 ? ASN A 106 ? SER A 100 ASN A 106 1 ? 7  
HELX_P HELX_P6  AA6 ASN A 106 ? GLU A 118 ? ASN A 106 GLU A 118 1 ? 13 
HELX_P HELX_P7  AA7 GLU A 124 ? ASP A 130 ? GLU A 124 ASP A 130 5 ? 7  
HELX_P HELX_P8  AA8 GLU B 4   ? GLY B 13  ? GLU B 4   GLY B 13  1 ? 10 
HELX_P HELX_P9  AA9 PRO B 18  ? LEU B 22  ? PRO B 18  LEU B 22  5 ? 5  
HELX_P HELX_P10 AB1 ASP B 25  ? GLU B 38  ? ASP B 25  GLU B 38  1 ? 14 
HELX_P HELX_P11 AB2 TRP B 39  ? LEU B 42  ? TRP B 39  LEU B 42  5 ? 4  
HELX_P HELX_P12 AB3 SER B 100 ? ASN B 106 ? SER B 100 ASN B 106 1 ? 7  
HELX_P HELX_P13 AB4 PRO B 107 ? GLU B 118 ? PRO B 107 GLU B 118 1 ? 12 
HELX_P HELX_P14 AB5 GLU B 124 ? ASP B 130 ? GLU B 124 ASP B 130 5 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? B ILE 215 O ? ? ? 1_555 F K   . K ? ? B ILE 215 B K   303 1_555 ? ? ? ? ? ? ? 3.412 ? ? 
metalc2 metalc ? ? F K   .   K ? ? ? 1_555 I HOH . O ? ? B K   303 B HOH 487 1_555 ? ? ? ? ? ? ? 3.034 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_struct_conn_angle.id                    1 
_pdbx_struct_conn_angle.ptnr1_label_atom_id   O 
_pdbx_struct_conn_angle.ptnr1_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr1_label_asym_id   B 
_pdbx_struct_conn_angle.ptnr1_label_comp_id   ILE 
_pdbx_struct_conn_angle.ptnr1_label_seq_id    215 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id    B 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id    ILE 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id     215 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr1_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr2_label_atom_id   K 
_pdbx_struct_conn_angle.ptnr2_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr2_label_asym_id   F 
_pdbx_struct_conn_angle.ptnr2_label_comp_id   K 
_pdbx_struct_conn_angle.ptnr2_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id    B 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id    K 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id     303 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr2_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr3_label_atom_id   O 
_pdbx_struct_conn_angle.ptnr3_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr3_label_asym_id   I 
_pdbx_struct_conn_angle.ptnr3_label_comp_id   HOH 
_pdbx_struct_conn_angle.ptnr3_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id    B 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id    HOH 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id     487 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr3_symmetry        1_555 
_pdbx_struct_conn_angle.value                 135.0 
_pdbx_struct_conn_angle.value_esd             ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 7 ? 
AA3 ? 2 ? 
AA4 ? 3 ? 
AA5 ? 7 ? 
AA6 ? 7 ? 
AA7 ? 2 ? 
AA8 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA6 6 7 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 14  ? LEU A 17  ? TYR A 14  LEU A 17  
AA1 2 THR A 200 ? SER A 204 ? THR A 200 SER A 204 
AA1 3 PHE A 163 ? PHE A 172 ? PHE A 163 PHE A 172 
AA1 4 ALA A 224 ? HIS A 235 ? ALA A 224 HIS A 235 
AA1 5 TRP A 132 ? SER A 143 ? TRP A 132 SER A 143 
AA1 6 PHE A 54  ? VAL A 65  ? PHE A 54  VAL A 65  
AA1 7 GLU A 70  ? LEU A 73  ? GLU A 70  LEU A 73  
AA2 1 TYR A 14  ? LEU A 17  ? TYR A 14  LEU A 17  
AA2 2 THR A 200 ? SER A 204 ? THR A 200 SER A 204 
AA2 3 PHE A 163 ? PHE A 172 ? PHE A 163 PHE A 172 
AA2 4 ALA A 224 ? HIS A 235 ? ALA A 224 HIS A 235 
AA2 5 TRP A 132 ? SER A 143 ? TRP A 132 SER A 143 
AA2 6 PHE A 54  ? VAL A 65  ? PHE A 54  VAL A 65  
AA2 7 ALA A 97  ? PRO A 98  ? ALA A 97  PRO A 98  
AA3 1 ALA A 174 ? GLY A 176 ? ALA A 174 GLY A 176 
AA3 2 ILE A 215 ? PRO A 217 ? ILE A 215 PRO A 217 
AA4 1 LEU A 188 ? PHE A 192 ? LEU A 188 PHE A 192 
AA4 2 SER A 179 ? TYR A 182 ? SER A 179 TYR A 182 
AA4 3 LEU A 209 ? VAL A 212 ? LEU A 209 VAL A 212 
AA5 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA5 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA5 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA5 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA5 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA5 6 ARG B 53  ? VAL B 65  ? ARG B 53  VAL B 65  
AA5 7 GLU B 43  ? THR B 44  ? GLU B 43  THR B 44  
AA6 1 TYR B 14  ? LEU B 17  ? TYR B 14  LEU B 17  
AA6 2 THR B 200 ? SER B 204 ? THR B 200 SER B 204 
AA6 3 PHE B 163 ? PHE B 172 ? PHE B 163 PHE B 172 
AA6 4 ALA B 224 ? HIS B 235 ? ALA B 224 HIS B 235 
AA6 5 TRP B 132 ? SER B 143 ? TRP B 132 SER B 143 
AA6 6 ARG B 53  ? VAL B 65  ? ARG B 53  VAL B 65  
AA6 7 GLU B 70  ? LEU B 73  ? GLU B 70  LEU B 73  
AA7 1 ALA B 174 ? GLY B 176 ? ALA B 174 GLY B 176 
AA7 2 ILE B 215 ? PRO B 217 ? ILE B 215 PRO B 217 
AA8 1 LEU B 188 ? PHE B 192 ? LEU B 188 PHE B 192 
AA8 2 SER B 179 ? TYR B 182 ? SER B 179 TYR B 182 
AA8 3 LEU B 209 ? VAL B 212 ? LEU B 209 VAL B 212 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 17  ? N LEU A 17  O THR A 200 ? O THR A 200 
AA1 2 3 O TRP A 203 ? O TRP A 203 N GLY A 164 ? N GLY A 164 
AA1 3 4 N PHE A 163 ? N PHE A 163 O TYR A 233 ? O TYR A 233 
AA1 4 5 O ILE A 230 ? O ILE A 230 N HIS A 137 ? N HIS A 137 
AA1 5 6 O CYS A 136 ? O CYS A 136 N ASP A 60  ? N ASP A 60  
AA1 6 7 N PHE A 63  ? N PHE A 63  O ARG A 72  ? O ARG A 72  
AA2 1 2 N LEU A 17  ? N LEU A 17  O THR A 200 ? O THR A 200 
AA2 2 3 O TRP A 203 ? O TRP A 203 N GLY A 164 ? N GLY A 164 
AA2 3 4 N PHE A 163 ? N PHE A 163 O TYR A 233 ? O TYR A 233 
AA2 4 5 O ILE A 230 ? O ILE A 230 N HIS A 137 ? N HIS A 137 
AA2 5 6 O CYS A 136 ? O CYS A 136 N ASP A 60  ? N ASP A 60  
AA2 6 7 N TYR A 59  ? N TYR A 59  O ALA A 97  ? O ALA A 97  
AA3 1 2 N ALA A 175 ? N ALA A 175 O HIS A 216 ? O HIS A 216 
AA4 1 2 O ALA A 190 ? O ALA A 190 N VAL A 181 ? N VAL A 181 
AA4 2 3 N TYR A 182 ? N TYR A 182 O LEU A 209 ? O LEU A 209 
AA5 1 2 N LEU B 17  ? N LEU B 17  O THR B 200 ? O THR B 200 
AA5 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA5 3 4 N GLY B 170 ? N GLY B 170 O ASP B 227 ? O ASP B 227 
AA5 4 5 O ALA B 224 ? O ALA B 224 N SER B 143 ? N SER B 143 
AA5 5 6 O ILE B 142 ? O ILE B 142 N PHE B 54  ? N PHE B 54  
AA5 6 7 O ARG B 57  ? O ARG B 57  N GLU B 43  ? N GLU B 43  
AA6 1 2 N LEU B 17  ? N LEU B 17  O THR B 200 ? O THR B 200 
AA6 2 3 O TRP B 203 ? O TRP B 203 N GLY B 164 ? N GLY B 164 
AA6 3 4 N GLY B 170 ? N GLY B 170 O ASP B 227 ? O ASP B 227 
AA6 4 5 O ALA B 224 ? O ALA B 224 N SER B 143 ? N SER B 143 
AA6 5 6 O ILE B 142 ? O ILE B 142 N PHE B 54  ? N PHE B 54  
AA6 6 7 N PHE B 63  ? N PHE B 63  O ARG B 72  ? O ARG B 72  
AA7 1 2 N ALA B 175 ? N ALA B 175 O HIS B 216 ? O HIS B 216 
AA8 1 2 O PHE B 192 ? O PHE B 192 N SER B 179 ? N SER B 179 
AA8 2 3 N TYR B 182 ? N TYR B 182 O LEU B 209 ? O LEU B 209 
# 
_pdbx_entry_details.entry_id                   9DQP 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   B HOH 514 ? ? O B HOH 535 ? ? 1.67 
2  1 O   A GLU 43  ? ? O A HOH 401 ? ? 1.76 
3  1 O   A HOH 519 ? ? O A HOH 538 ? ? 1.89 
4  1 O   B HOH 474 ? ? O B HOH 547 ? ? 1.90 
5  1 O   B HOH 529 ? ? O B HOH 549 ? ? 1.91 
6  1 O   A HOH 578 ? ? O A HOH 589 ? ? 1.95 
7  1 O   A HOH 442 ? ? O A HOH 567 ? ? 1.96 
8  1 O   B HOH 533 ? ? O B HOH 539 ? ? 1.96 
9  1 O   B HOH 534 ? ? O B HOH 562 ? ? 1.98 
10 1 O   A HOH 585 ? ? O A HOH 594 ? ? 1.98 
11 1 OE2 A GLU 70  ? ? O A HOH 402 ? ? 2.01 
12 1 O   A HOH 593 ? ? O A HOH 602 ? ? 2.03 
13 1 OE2 B GLU 160 ? ? O B HOH 401 ? ? 2.03 
14 1 O   B HOH 414 ? ? O B HOH 550 ? ? 2.03 
15 1 O   A HOH 423 ? ? O A HOH 482 ? ? 2.04 
16 1 O   A HOH 591 ? ? O A HOH 606 ? ? 2.04 
17 1 OG  B SER 126 ? ? O B HOH 402 ? ? 2.06 
18 1 O   B HOH 540 ? ? O B HOH 551 ? ? 2.06 
19 1 O   B THR 221 ? ? O B HOH 403 ? ? 2.10 
20 1 NH1 B ARG 240 ? ? O B HOH 404 ? ? 2.10 
21 1 O   A HOH 416 ? ? O A HOH 532 ? ? 2.11 
22 1 O   A HOH 426 ? ? O A HOH 514 ? ? 2.12 
23 1 O   A HOH 546 ? ? O A HOH 556 ? ? 2.12 
24 1 O   A HOH 507 ? ? O A HOH 568 ? ? 2.13 
25 1 NE2 A HIS 157 ? ? O A HOH 403 ? ? 2.13 
26 1 O   B HOH 418 ? ? O B HOH 493 ? ? 2.15 
27 1 O   B HOH 545 ? ? O B HOH 560 ? ? 2.16 
28 1 O   B HOH 418 ? ? O B HOH 438 ? ? 2.16 
29 1 NH1 B ARG 61  ? ? O B HOH 405 ? ? 2.16 
30 1 O   B HOH 509 ? ? O B HOH 564 ? ? 2.17 
31 1 OE1 A GLU 70  ? ? O A HOH 404 ? ? 2.17 
32 1 O   A HOH 568 ? ? O A HOH 582 ? ? 2.18 
33 1 NE  A ARG 21  ? ? O A HOH 405 ? ? 2.18 
34 1 NH1 A ARG 241 ? ? O A HOH 406 ? ? 2.18 
35 1 O   A HOH 412 ? ? O A HOH 522 ? ? 2.19 
36 1 O   A HOH 460 ? ? O A HOH 549 ? ? 2.19 
37 1 O   A THR 221 ? ? O A HOH 407 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     442 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     511 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_556 
_pdbx_validate_symm_contact.dist              1.86 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 22  ? ? 65.49   98.30   
2 1 ILE A 24  ? ? -170.14 123.49  
3 1 ASN A 86  ? ? 34.81   57.87   
4 1 ASP A 93  ? ? -95.84  41.54   
5 1 ASP B 25  ? ? -83.09  -154.30 
6 1 ASP B 45  ? ? 65.28   125.89  
7 1 SER B 52  ? ? 162.69  -24.98  
8 1 PRO B 145 ? ? -21.94  125.41  
9 1 VAL B 218 ? ? -74.96  -70.24  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ILE 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    24 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   ASP 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    25 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            144.28 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     538 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   I 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 605 ? 5.81 . 
2 1 O ? A HOH 606 ? 6.10 . 
3 1 O ? A HOH 607 ? 6.12 . 
4 1 O ? A HOH 608 ? 6.31 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ARG 46  ? A ARG 46  
3  1 Y 1 A TYR 47  ? A TYR 47  
4  1 Y 1 A LEU 48  ? A LEU 48  
5  1 Y 1 A LYS 49  ? A LYS 49  
6  1 Y 1 A GLY 50  ? A GLY 50  
7  1 Y 1 A GLY 51  ? A GLY 51  
8  1 Y 1 A SER 52  ? A SER 52  
9  1 Y 1 A GLU 147 ? A GLU 147 
10 1 Y 1 A THR 148 ? A THR 148 
11 1 Y 1 A GLY 149 ? A GLY 149 
12 1 Y 1 A GLU 150 ? A GLU 150 
13 1 Y 1 A PRO 151 ? A PRO 151 
14 1 Y 1 A THR 152 ? A THR 152 
15 1 Y 1 A GLY 245 ? A GLY 245 
16 1 Y 1 A ALA 246 ? A ALA 246 
17 1 Y 1 A ALA 247 ? A ALA 247 
18 1 Y 1 A HIS 248 ? A HIS 248 
19 1 Y 1 A HIS 249 ? A HIS 249 
20 1 Y 1 A HIS 250 ? A HIS 250 
21 1 Y 1 A HIS 251 ? A HIS 251 
22 1 Y 1 A HIS 252 ? A HIS 252 
23 1 Y 1 A HIS 253 ? A HIS 253 
24 1 Y 1 B MET 1   ? B MET 1   
25 1 Y 1 B GLN 2   ? B GLN 2   
26 1 Y 1 B TYR 47  ? B TYR 47  
27 1 Y 1 B LEU 48  ? B LEU 48  
28 1 Y 1 B LYS 49  ? B LYS 49  
29 1 Y 1 B GLY 50  ? B GLY 50  
30 1 Y 1 B GLN 81  ? B GLN 81  
31 1 Y 1 B SER 82  ? B SER 82  
32 1 Y 1 B MET 83  ? B MET 83  
33 1 Y 1 B ASN 84  ? B ASN 84  
34 1 Y 1 B ALA 85  ? B ALA 85  
35 1 Y 1 B ASN 86  ? B ASN 86  
36 1 Y 1 B ASP 87  ? B ASP 87  
37 1 Y 1 B TYR 88  ? B TYR 88  
38 1 Y 1 B ALA 89  ? B ALA 89  
39 1 Y 1 B GLY 90  ? B GLY 90  
40 1 Y 1 B GLY 91  ? B GLY 91  
41 1 Y 1 B ILE 92  ? B ILE 92  
42 1 Y 1 B ASP 93  ? B ASP 93  
43 1 Y 1 B ARG 94  ? B ARG 94  
44 1 Y 1 B THR 148 ? B THR 148 
45 1 Y 1 B GLY 149 ? B GLY 149 
46 1 Y 1 B GLU 150 ? B GLU 150 
47 1 Y 1 B GLN 244 ? B GLN 244 
48 1 Y 1 B GLY 245 ? B GLY 245 
49 1 Y 1 B ALA 246 ? B ALA 246 
50 1 Y 1 B ALA 247 ? B ALA 247 
51 1 Y 1 B HIS 248 ? B HIS 248 
52 1 Y 1 B HIS 249 ? B HIS 249 
53 1 Y 1 B HIS 250 ? B HIS 250 
54 1 Y 1 B HIS 251 ? B HIS 251 
55 1 Y 1 B HIS 252 ? B HIS 252 
56 1 Y 1 B HIS 253 ? B HIS 253 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
K   K    K N N 197 
LEU N    N N N 198 
LEU CA   C N S 199 
LEU C    C N N 200 
LEU O    O N N 201 
LEU CB   C N N 202 
LEU CG   C N N 203 
LEU CD1  C N N 204 
LEU CD2  C N N 205 
LEU OXT  O N N 206 
LEU H    H N N 207 
LEU H2   H N N 208 
LEU HA   H N N 209 
LEU HB2  H N N 210 
LEU HB3  H N N 211 
LEU HG   H N N 212 
LEU HD11 H N N 213 
LEU HD12 H N N 214 
LEU HD13 H N N 215 
LEU HD21 H N N 216 
LEU HD22 H N N 217 
LEU HD23 H N N 218 
LEU HXT  H N N 219 
LYS N    N N N 220 
LYS CA   C N S 221 
LYS C    C N N 222 
LYS O    O N N 223 
LYS CB   C N N 224 
LYS CG   C N N 225 
LYS CD   C N N 226 
LYS CE   C N N 227 
LYS NZ   N N N 228 
LYS OXT  O N N 229 
LYS H    H N N 230 
LYS H2   H N N 231 
LYS HA   H N N 232 
LYS HB2  H N N 233 
LYS HB3  H N N 234 
LYS HG2  H N N 235 
LYS HG3  H N N 236 
LYS HD2  H N N 237 
LYS HD3  H N N 238 
LYS HE2  H N N 239 
LYS HE3  H N N 240 
LYS HZ1  H N N 241 
LYS HZ2  H N N 242 
LYS HZ3  H N N 243 
LYS HXT  H N N 244 
MET N    N N N 245 
MET CA   C N S 246 
MET C    C N N 247 
MET O    O N N 248 
MET CB   C N N 249 
MET CG   C N N 250 
MET SD   S N N 251 
MET CE   C N N 252 
MET OXT  O N N 253 
MET H    H N N 254 
MET H2   H N N 255 
MET HA   H N N 256 
MET HB2  H N N 257 
MET HB3  H N N 258 
MET HG2  H N N 259 
MET HG3  H N N 260 
MET HE1  H N N 261 
MET HE2  H N N 262 
MET HE3  H N N 263 
MET HXT  H N N 264 
PHE N    N N N 265 
PHE CA   C N S 266 
PHE C    C N N 267 
PHE O    O N N 268 
PHE CB   C N N 269 
PHE CG   C Y N 270 
PHE CD1  C Y N 271 
PHE CD2  C Y N 272 
PHE CE1  C Y N 273 
PHE CE2  C Y N 274 
PHE CZ   C Y N 275 
PHE OXT  O N N 276 
PHE H    H N N 277 
PHE H2   H N N 278 
PHE HA   H N N 279 
PHE HB2  H N N 280 
PHE HB3  H N N 281 
PHE HD1  H N N 282 
PHE HD2  H N N 283 
PHE HE1  H N N 284 
PHE HE2  H N N 285 
PHE HZ   H N N 286 
PHE HXT  H N N 287 
PRO N    N N N 288 
PRO CA   C N S 289 
PRO C    C N N 290 
PRO O    O N N 291 
PRO CB   C N N 292 
PRO CG   C N N 293 
PRO CD   C N N 294 
PRO OXT  O N N 295 
PRO H    H N N 296 
PRO HA   H N N 297 
PRO HB2  H N N 298 
PRO HB3  H N N 299 
PRO HG2  H N N 300 
PRO HG3  H N N 301 
PRO HD2  H N N 302 
PRO HD3  H N N 303 
PRO HXT  H N N 304 
SCN S    S N N 305 
SCN C    C N N 306 
SCN N    N N N 307 
SER N    N N N 308 
SER CA   C N S 309 
SER C    C N N 310 
SER O    O N N 311 
SER CB   C N N 312 
SER OG   O N N 313 
SER OXT  O N N 314 
SER H    H N N 315 
SER H2   H N N 316 
SER HA   H N N 317 
SER HB2  H N N 318 
SER HB3  H N N 319 
SER HG   H N N 320 
SER HXT  H N N 321 
THR N    N N N 322 
THR CA   C N S 323 
THR C    C N N 324 
THR O    O N N 325 
THR CB   C N R 326 
THR OG1  O N N 327 
THR CG2  C N N 328 
THR OXT  O N N 329 
THR H    H N N 330 
THR H2   H N N 331 
THR HA   H N N 332 
THR HB   H N N 333 
THR HG1  H N N 334 
THR HG21 H N N 335 
THR HG22 H N N 336 
THR HG23 H N N 337 
THR HXT  H N N 338 
TRP N    N N N 339 
TRP CA   C N S 340 
TRP C    C N N 341 
TRP O    O N N 342 
TRP CB   C N N 343 
TRP CG   C Y N 344 
TRP CD1  C Y N 345 
TRP CD2  C Y N 346 
TRP NE1  N Y N 347 
TRP CE2  C Y N 348 
TRP CE3  C Y N 349 
TRP CZ2  C Y N 350 
TRP CZ3  C Y N 351 
TRP CH2  C Y N 352 
TRP OXT  O N N 353 
TRP H    H N N 354 
TRP H2   H N N 355 
TRP HA   H N N 356 
TRP HB2  H N N 357 
TRP HB3  H N N 358 
TRP HD1  H N N 359 
TRP HE1  H N N 360 
TRP HE3  H N N 361 
TRP HZ2  H N N 362 
TRP HZ3  H N N 363 
TRP HH2  H N N 364 
TRP HXT  H N N 365 
TYR N    N N N 366 
TYR CA   C N S 367 
TYR C    C N N 368 
TYR O    O N N 369 
TYR CB   C N N 370 
TYR CG   C Y N 371 
TYR CD1  C Y N 372 
TYR CD2  C Y N 373 
TYR CE1  C Y N 374 
TYR CE2  C Y N 375 
TYR CZ   C Y N 376 
TYR OH   O N N 377 
TYR OXT  O N N 378 
TYR H    H N N 379 
TYR H2   H N N 380 
TYR HA   H N N 381 
TYR HB2  H N N 382 
TYR HB3  H N N 383 
TYR HD1  H N N 384 
TYR HD2  H N N 385 
TYR HE1  H N N 386 
TYR HE2  H N N 387 
TYR HH   H N N 388 
TYR HXT  H N N 389 
VAL N    N N N 390 
VAL CA   C N S 391 
VAL C    C N N 392 
VAL O    O N N 393 
VAL CB   C N N 394 
VAL CG1  C N N 395 
VAL CG2  C N N 396 
VAL OXT  O N N 397 
VAL H    H N N 398 
VAL H2   H N N 399 
VAL HA   H N N 400 
VAL HB   H N N 401 
VAL HG11 H N N 402 
VAL HG12 H N N 403 
VAL HG13 H N N 404 
VAL HG21 H N N 405 
VAL HG22 H N N 406 
VAL HG23 H N N 407 
VAL HXT  H N N 408 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SCN S   C    sing N N 290 
SCN C   N    trip N N 291 
SER N   CA   sing N N 292 
SER N   H    sing N N 293 
SER N   H2   sing N N 294 
SER CA  C    sing N N 295 
SER CA  CB   sing N N 296 
SER CA  HA   sing N N 297 
SER C   O    doub N N 298 
SER C   OXT  sing N N 299 
SER CB  OG   sing N N 300 
SER CB  HB2  sing N N 301 
SER CB  HB3  sing N N 302 
SER OG  HG   sing N N 303 
SER OXT HXT  sing N N 304 
THR N   CA   sing N N 305 
THR N   H    sing N N 306 
THR N   H2   sing N N 307 
THR CA  C    sing N N 308 
THR CA  CB   sing N N 309 
THR CA  HA   sing N N 310 
THR C   O    doub N N 311 
THR C   OXT  sing N N 312 
THR CB  OG1  sing N N 313 
THR CB  CG2  sing N N 314 
THR CB  HB   sing N N 315 
THR OG1 HG1  sing N N 316 
THR CG2 HG21 sing N N 317 
THR CG2 HG22 sing N N 318 
THR CG2 HG23 sing N N 319 
THR OXT HXT  sing N N 320 
TRP N   CA   sing N N 321 
TRP N   H    sing N N 322 
TRP N   H2   sing N N 323 
TRP CA  C    sing N N 324 
TRP CA  CB   sing N N 325 
TRP CA  HA   sing N N 326 
TRP C   O    doub N N 327 
TRP C   OXT  sing N N 328 
TRP CB  CG   sing N N 329 
TRP CB  HB2  sing N N 330 
TRP CB  HB3  sing N N 331 
TRP CG  CD1  doub Y N 332 
TRP CG  CD2  sing Y N 333 
TRP CD1 NE1  sing Y N 334 
TRP CD1 HD1  sing N N 335 
TRP CD2 CE2  doub Y N 336 
TRP CD2 CE3  sing Y N 337 
TRP NE1 CE2  sing Y N 338 
TRP NE1 HE1  sing N N 339 
TRP CE2 CZ2  sing Y N 340 
TRP CE3 CZ3  doub Y N 341 
TRP CE3 HE3  sing N N 342 
TRP CZ2 CH2  doub Y N 343 
TRP CZ2 HZ2  sing N N 344 
TRP CZ3 CH2  sing Y N 345 
TRP CZ3 HZ3  sing N N 346 
TRP CH2 HH2  sing N N 347 
TRP OXT HXT  sing N N 348 
TYR N   CA   sing N N 349 
TYR N   H    sing N N 350 
TYR N   H2   sing N N 351 
TYR CA  C    sing N N 352 
TYR CA  CB   sing N N 353 
TYR CA  HA   sing N N 354 
TYR C   O    doub N N 355 
TYR C   OXT  sing N N 356 
TYR CB  CG   sing N N 357 
TYR CB  HB2  sing N N 358 
TYR CB  HB3  sing N N 359 
TYR CG  CD1  doub Y N 360 
TYR CG  CD2  sing Y N 361 
TYR CD1 CE1  sing Y N 362 
TYR CD1 HD1  sing N N 363 
TYR CD2 CE2  doub Y N 364 
TYR CD2 HD2  sing N N 365 
TYR CE1 CZ   doub Y N 366 
TYR CE1 HE1  sing N N 367 
TYR CE2 CZ   sing Y N 368 
TYR CE2 HE2  sing N N 369 
TYR CZ  OH   sing N N 370 
TYR OH  HH   sing N N 371 
TYR OXT HXT  sing N N 372 
VAL N   CA   sing N N 373 
VAL N   H    sing N N 374 
VAL N   H2   sing N N 375 
VAL CA  C    sing N N 376 
VAL CA  CB   sing N N 377 
VAL CA  HA   sing N N 378 
VAL C   O    doub N N 379 
VAL C   OXT  sing N N 380 
VAL CB  CG1  sing N N 381 
VAL CB  CG2  sing N N 382 
VAL CB  HB   sing N N 383 
VAL CG1 HG11 sing N N 384 
VAL CG1 HG12 sing N N 385 
VAL CG1 HG13 sing N N 386 
VAL CG2 HG21 sing N N 387 
VAL CG2 HG22 sing N N 388 
VAL CG2 HG23 sing N N 389 
VAL OXT HXT  sing N N 390 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8JMS 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.crystal_system   monoclinic 
_space_group.IT_number        5 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DQP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010304 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003155 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.023293 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008251 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
K ? ? 16.37977 2.54835 ? ? 4.54127  84.28225 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 2   ? 13.20645  15.92008  40.58887  1.000 40.61296 ? 2   GLN A N   1 
ATOM   2    C CA  . GLN A 1 2   ? 11.90672  15.26493  40.68393  1.000 38.90638 ? 2   GLN A CA  1 
ATOM   3    C C   . GLN A 1 2   ? 11.06624  15.51556  39.42741  1.000 41.46928 ? 2   GLN A C   1 
ATOM   4    O O   . GLN A 1 2   ? 10.37839  14.61790  38.93544  1.000 38.56280 ? 2   GLN A O   1 
ATOM   5    C CB  . GLN A 1 2   ? 11.15643  15.75330  41.92930  1.000 41.47185 ? 2   GLN A CB  1 
ATOM   6    C CG  . GLN A 1 2   ? 10.97107  17.27918  41.97051  1.000 57.08142 ? 2   GLN A CG  1 
ATOM   7    C CD  . GLN A 1 2   ? 10.11321  17.76543  43.13121  1.000 67.39144 ? 2   GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 2   ? 9.20674   17.06347  43.59191  1.000 55.97057 ? 2   GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 2   ? 10.39736  18.98017  43.60764  1.000 55.87409 ? 2   GLN A NE2 1 
ATOM   10   N N   . THR A 1 3   ? 11.13420  16.73890  38.89516  1.000 51.18929 ? 3   THR A N   1 
ATOM   11   C CA  . THR A 1 3   ? 10.16316  17.14126  37.88066  1.000 51.79994 ? 3   THR A CA  1 
ATOM   12   C C   . THR A 1 3   ? 10.52540  16.58529  36.50498  1.000 36.00914 ? 3   THR A C   1 
ATOM   13   O O   . THR A 1 3   ? 9.63751   16.15423  35.75716  1.000 33.07493 ? 3   THR A O   1 
ATOM   14   C CB  . THR A 1 3   ? 10.02093  18.67305  37.86957  1.000 55.39998 ? 3   THR A CB  1 
ATOM   15   O OG1 . THR A 1 3   ? 9.00130   19.06401  36.93964  1.000 51.00276 ? 3   THR A OG1 1 
ATOM   16   C CG2 . THR A 1 3   ? 11.33846  19.35982  37.51467  1.000 56.86665 ? 3   THR A CG2 1 
ATOM   17   N N   . GLU A 1 4   ? 11.82003  16.56229  36.16621  1.000 42.60637 ? 4   GLU A N   1 
ATOM   18   C CA  . GLU A 1 4   ? 12.27609  15.80943  34.99658  1.000 47.37227 ? 4   GLU A CA  1 
ATOM   19   C C   . GLU A 1 4   ? 12.00574  14.31331  35.14797  1.000 27.48748 ? 4   GLU A C   1 
ATOM   20   O O   . GLU A 1 4   ? 11.65962  13.64040  34.16572  1.000 21.50677 ? 4   GLU A O   1 
ATOM   21   C CB  . GLU A 1 4   ? 13.76863  16.06408  34.74826  1.000 43.66856 ? 4   GLU A CB  1 
ATOM   22   C CG  . GLU A 1 4   ? 14.71016  15.49828  35.80784  1.000 44.84721 ? 4   GLU A CG  1 
ATOM   23   C CD  . GLU A 1 4   ? 14.31130  15.91831  37.21376  1.000 60.60773 ? 4   GLU A CD  1 
ATOM   24   O OE1 . GLU A 1 4   ? 14.08135  17.13689  37.40546  1.000 65.48558 ? 4   GLU A OE1 1 
ATOM   25   O OE2 . GLU A 1 4   ? 14.17452  15.04101  38.10786  1.000 46.58625 ? 4   GLU A OE2 1 
ATOM   26   N N   . ALA A 1 5   ? 12.12972  13.77959  36.36835  1.000 30.54251 ? 5   ALA A N   1 
ATOM   27   C CA  . ALA A 1 5   ? 11.86750  12.36012  36.58650  1.000 25.36867 ? 5   ALA A CA  1 
ATOM   28   C C   . ALA A 1 5   ? 10.40572  12.02082  36.33232  1.000 22.06116 ? 5   ALA A C   1 
ATOM   29   O O   . ALA A 1 5   ? 10.10172  11.03595  35.65210  1.000 18.08873 ? 5   ALA A O   1 
ATOM   30   C CB  . ALA A 1 5   ? 12.27007  11.96042  38.00541  1.000 26.87066 ? 5   ALA A CB  1 
ATOM   31   N N   . ARG A 1 6   ? 9.48325   12.78996  36.91968  1.000 16.94344 ? 6   ARG A N   1 
ATOM   32   C CA  . ARG A 1 6   ? 8.06742   12.53979  36.66778  1.000 25.52494 ? 6   ARG A CA  1 
ATOM   33   C C   . ARG A 1 6   ? 7.78006   12.52926  35.18124  1.000 16.06448 ? 6   ARG A C   1 
ATOM   34   O O   . ARG A 1 6   ? 7.00796   11.69889  34.69075  1.000 20.35777 ? 6   ARG A O   1 
ATOM   35   C CB  . ARG A 1 6   ? 7.19001   13.60545  37.32585  1.000 22.59412 ? 6   ARG A CB  1 
ATOM   36   C CG  . ARG A 1 6   ? 7.22390   13.62465  38.81945  1.000 28.71784 ? 6   ARG A CG  1 
ATOM   37   C CD  . ARG A 1 6   ? 6.08119   14.46116  39.30669  1.000 20.58285 ? 6   ARG A CD  1 
ATOM   38   N NE  . ARG A 1 6   ? 6.20993   14.75579  40.72087  1.000 35.35688 ? 6   ARG A NE  1 
ATOM   39   C CZ  . ARG A 1 6   ? 5.18216   14.86177  41.54787  1.000 42.46772 ? 6   ARG A CZ  1 
ATOM   40   N NH1 . ARG A 1 6   ? 3.93897   14.64017  41.13496  1.000 40.57720 ? 6   ARG A NH1 1 
ATOM   41   N NH2 . ARG A 1 6   ? 5.40661   15.18765  42.82019  1.000 43.80674 ? 6   ARG A NH2 1 
ATOM   42   N N   . GLU A 1 7   ? 8.39260   13.44997  34.45349  1.000 18.69205 ? 7   GLU A N   1 
ATOM   43   C CA  . GLU A 1 7   ? 8.11077   13.55639  33.03246  1.000 27.31685 ? 7   GLU A CA  1 
ATOM   44   C C   . GLU A 1 7   ? 8.74515   12.40348  32.27753  1.000 24.56489 ? 7   GLU A C   1 
ATOM   45   O O   . GLU A 1 7   ? 8.15272   11.86922  31.32997  1.000 21.11892 ? 7   GLU A O   1 
ATOM   46   C CB  . GLU A 1 7   ? 8.60179   14.90257  32.50279  1.000 31.28440 ? 7   GLU A CB  1 
ATOM   47   C CG  . GLU A 1 7   ? 8.10397   15.18257  31.09710  1.000 32.82580 ? 7   GLU A CG  1 
ATOM   48   C CD  . GLU A 1 7   ? 6.63202   14.82460  30.92788  1.000 36.65422 ? 7   GLU A CD  1 
ATOM   49   O OE1 . GLU A 1 7   ? 5.77774   15.37248  31.67152  1.000 35.45501 ? 7   GLU A OE1 1 
ATOM   50   O OE2 . GLU A 1 7   ? 6.33307   13.97385  30.05716  1.000 45.09865 ? 7   GLU A OE2 1 
ATOM   51   N N   . GLU A 1 8   ? 9.94280   11.99410  32.70406  1.000 22.51099 ? 8   GLU A N   1 
ATOM   52   C CA  . GLU A 1 8   ? 10.55872  10.81315  32.11837  1.000 20.21885 ? 8   GLU A CA  1 
ATOM   53   C C   . GLU A 1 8   ? 9.72798   9.57073   32.39680  1.000 14.38178 ? 8   GLU A C   1 
ATOM   54   O O   . GLU A 1 8   ? 9.54225   8.73252   31.49930  1.000 18.72558 ? 8   GLU A O   1 
ATOM   55   C CB  . GLU A 1 8   ? 12.00049  10.67345  32.62436  1.000 16.40734 ? 8   GLU A CB  1 
ATOM   56   C CG  . GLU A 1 8   ? 12.92719  11.62694  31.92376  1.000 15.81900 ? 8   GLU A CG  1 
ATOM   57   C CD  . GLU A 1 8   ? 14.31363  11.68017  32.52297  1.000 24.03654 ? 8   GLU A CD  1 
ATOM   58   O OE1 . GLU A 1 8   ? 14.62372  10.86724  33.41479  1.000 22.89050 ? 8   GLU A OE1 1 
ATOM   59   O OE2 . GLU A 1 8   ? 15.09768  12.55460  32.10324  1.000 28.59320 ? 8   GLU A OE2 1 
ATOM   60   N N   . LEU A 1 9   ? 9.17799   9.43969   33.61446  1.000 11.88459 ? 9   LEU A N   1 
ATOM   61   C CA  . LEU A 1 9   ? 8.31543   8.28511   33.86297  1.000 9.37666  ? 9   LEU A CA  1 
ATOM   62   C C   . LEU A 1 9   ? 7.07635   8.34004   32.97933  1.000 15.66595 ? 9   LEU A C   1 
ATOM   63   O O   . LEU A 1 9   ? 6.66912   7.32578   32.39542  1.000 17.71528 ? 9   LEU A O   1 
ATOM   64   C CB  . LEU A 1 9   ? 7.88383   8.20913   35.32744  1.000 15.41171 ? 9   LEU A CB  1 
ATOM   65   C CG  . LEU A 1 9   ? 8.81386   7.84177   36.49416  1.000 19.31956 ? 9   LEU A CG  1 
ATOM   66   C CD1 . LEU A 1 9   ? 8.12121   6.92704   37.51719  1.000 13.66666 ? 9   LEU A CD1 1 
ATOM   67   C CD2 . LEU A 1 9   ? 10.05958  7.23069   35.97814  1.000 10.17235 ? 9   LEU A CD2 1 
ATOM   68   N N   . ARG A 1 10  ? 6.45814   9.51572   32.87691  1.000 16.40548 ? 10  ARG A N   1 
ATOM   69   C CA  . ARG A 1 10  ? 5.31064   9.67541   31.98319  1.000 19.48847 ? 10  ARG A CA  1 
ATOM   70   C C   . ARG A 1 10  ? 5.66253   9.26916   30.55338  1.000 17.85453 ? 10  ARG A C   1 
ATOM   71   O O   . ARG A 1 10  ? 4.96730   8.45550   29.92750  1.000 17.41171 ? 10  ARG A O   1 
ATOM   72   C CB  . ARG A 1 10  ? 4.82575   11.12871  32.02658  1.000 24.26190 ? 10  ARG A CB  1 
ATOM   73   C CG  . ARG A 1 10  ? 3.40815   11.29897  32.55380  1.000 38.36793 ? 10  ARG A CG  1 
ATOM   74   C CD  . ARG A 1 10  ? 3.01470   12.77167  32.67714  1.000 33.09875 ? 10  ARG A CD  1 
ATOM   75   N NE  . ARG A 1 10  ? 2.78446   13.16367  34.06407  1.000 32.27403 ? 10  ARG A NE  1 
ATOM   76   C CZ  . ARG A 1 10  ? 3.55219   13.99849  34.75423  1.000 32.94260 ? 10  ARG A CZ  1 
ATOM   77   N NH1 . ARG A 1 10  ? 4.60560   14.58180  34.21096  1.000 35.55366 ? 10  ARG A NH1 1 
ATOM   78   N NH2 . ARG A 1 10  ? 3.24581   14.26733  36.02097  1.000 33.38449 ? 10  ARG A NH2 1 
ATOM   79   N N   . ALA A 1 11  ? 6.76148   9.80583   30.03045  1.000 21.25566 ? 11  ALA A N   1 
ATOM   80   C CA  . ALA A 1 11  ? 7.08602   9.60738   28.61975  1.000 23.75312 ? 11  ALA A CA  1 
ATOM   81   C C   . ALA A 1 11  ? 7.63763   8.21069   28.34281  1.000 29.82117 ? 11  ALA A C   1 
ATOM   82   O O   . ALA A 1 11  ? 7.21445   7.54721   27.38426  1.000 19.94538 ? 11  ALA A O   1 
ATOM   83   C CB  . ALA A 1 11  ? 8.08695   10.67039  28.16528  1.000 25.10887 ? 11  ALA A CB  1 
ATOM   84   N N   . ASN A 1 12  ? 8.60089   7.75344   29.15505  1.000 16.37921 ? 12  ASN A N   1 
ATOM   85   C CA  . ASN A 1 12  ? 9.33482   6.52296   28.85780  1.000 19.71489 ? 12  ASN A CA  1 
ATOM   86   C C   . ASN A 1 12  ? 9.08591   5.39049   29.83768  1.000 17.26860 ? 12  ASN A C   1 
ATOM   87   O O   . ASN A 1 12  ? 9.52327   4.26867   29.57277  1.000 17.01774 ? 12  ASN A O   1 
ATOM   88   C CB  . ASN A 1 12  ? 10.84114  6.78089   28.83005  1.000 15.67868 ? 12  ASN A CB  1 
ATOM   89   C CG  . ASN A 1 12  ? 11.19584  8.07112   28.17075  1.000 18.68316 ? 12  ASN A CG  1 
ATOM   90   O OD1 . ASN A 1 12  ? 11.87858  8.89470   28.75908  1.000 18.36645 ? 12  ASN A OD1 1 
ATOM   91   N ND2 . ASN A 1 12  ? 10.74591  8.26015   26.93104  1.000 20.16065 ? 12  ASN A ND2 1 
ATOM   92   N N   . GLY A 1 13  ? 8.39876   5.63739   30.94609  1.000 9.82590  ? 13  GLY A N   1 
ATOM   93   C CA  . GLY A 1 13  ? 8.13961   4.58975   31.91004  1.000 10.00077 ? 13  GLY A CA  1 
ATOM   94   C C   . GLY A 1 13  ? 9.25231   4.36180   32.92188  1.000 9.33344  ? 13  GLY A C   1 
ATOM   95   O O   . GLY A 1 13  ? 9.07678   3.53304   33.81992  1.000 9.49365  ? 13  GLY A O   1 
ATOM   96   N N   . TYR A 1 14  ? 10.37987  5.06756   32.81296  1.000 9.38832  ? 14  TYR A N   1 
ATOM   97   C CA  . TYR A 1 14  ? 11.47885  4.89970   33.76801  1.000 9.10926  ? 14  TYR A CA  1 
ATOM   98   C C   . TYR A 1 14  ? 12.34073  6.14967   33.73396  1.000 11.98283 ? 14  TYR A C   1 
ATOM   99   O O   . TYR A 1 14  ? 12.27165  6.94410   32.79572  1.000 13.00501 ? 14  TYR A O   1 
ATOM   100  C CB  . TYR A 1 14  ? 12.32405  3.64951   33.45370  1.000 7.82298  ? 14  TYR A CB  1 
ATOM   101  C CG  . TYR A 1 14  ? 13.16509  3.84640   32.21832  1.000 6.95561  ? 14  TYR A CG  1 
ATOM   102  C CD1 . TYR A 1 14  ? 12.60847  3.70657   30.95576  1.000 11.88344 ? 14  TYR A CD1 1 
ATOM   103  C CD2 . TYR A 1 14  ? 14.51331  4.19911   32.31425  1.000 10.39583 ? 14  TYR A CD2 1 
ATOM   104  C CE1 . TYR A 1 14  ? 13.36027  3.90251   29.81651  1.000 10.56331 ? 14  TYR A CE1 1 
ATOM   105  C CE2 . TYR A 1 14  ? 15.28294  4.39612   31.16233  1.000 10.43851 ? 14  TYR A CE2 1 
ATOM   106  C CZ  . TYR A 1 14  ? 14.68750  4.25779   29.92308  1.000 11.19707 ? 14  TYR A CZ  1 
ATOM   107  O OH  . TYR A 1 14  ? 15.42719  4.47380   28.77403  1.000 13.17488 ? 14  TYR A OH  1 
ATOM   108  N N   . SER A 1 15  ? 13.16555  6.31657   34.77036  1.000 5.67773  ? 15  SER A N   1 
ATOM   109  C CA  . SER A 1 15  ? 14.03887  7.46946   34.89922  1.000 10.70981 ? 15  SER A CA  1 
ATOM   110  C C   . SER A 1 15  ? 15.23641  7.03183   35.72755  1.000 7.84435  ? 15  SER A C   1 
ATOM   111  O O   . SER A 1 15  ? 15.07595  6.26465   36.67160  1.000 9.98317  ? 15  SER A O   1 
ATOM   112  C CB  . SER A 1 15  ? 13.32111  8.65249   35.58822  1.000 12.42338 ? 15  SER A CB  1 
ATOM   113  O OG  . SER A 1 15  ? 14.17719  9.78516   35.68089  1.000 14.30232 ? 15  SER A OG  1 
ATOM   114  N N   . LEU A 1 16  ? 16.42500  7.49384   35.36791  1.000 10.97395 ? 16  LEU A N   1 
ATOM   115  C CA  . LEU A 1 16  ? 17.64856  7.06772   36.03640  1.000 11.25322 ? 16  LEU A CA  1 
ATOM   116  C C   . LEU A 1 16  ? 18.20735  8.22364   36.84547  1.000 15.19268 ? 16  LEU A C   1 
ATOM   117  O O   . LEU A 1 16  ? 18.07808  9.38377   36.44926  1.000 20.83743 ? 16  LEU A O   1 
ATOM   118  C CB  . LEU A 1 16  ? 18.70321  6.57219   35.02540  1.000 8.85933  ? 16  LEU A CB  1 
ATOM   119  C CG  . LEU A 1 16  ? 18.16390  5.50005   34.08932  1.000 12.96616 ? 16  LEU A CG  1 
ATOM   120  C CD1 . LEU A 1 16  ? 19.12569  5.14927   32.96987  1.000 12.50373 ? 16  LEU A CD1 1 
ATOM   121  C CD2 . LEU A 1 16  ? 17.79962  4.25316   34.87597  1.000 7.96133  ? 16  LEU A CD2 1 
ATOM   122  N N   . LEU A 1 17  ? 18.82774  7.90189   37.97979  1.000 10.72613 ? 17  LEU A N   1 
ATOM   123  C CA  . LEU A 1 17  ? 19.44576  8.90061   38.84760  1.000 12.12402 ? 17  LEU A CA  1 
ATOM   124  C C   . LEU A 1 17  ? 20.77252  8.36712   39.35466  1.000 12.64068 ? 17  LEU A C   1 
ATOM   125  O O   . LEU A 1 17  ? 20.83918  7.75417   40.43149  1.000 11.66893 ? 17  LEU A O   1 
ATOM   126  C CB  . LEU A 1 17  ? 18.54331  9.25067   40.02752  1.000 14.78425 ? 17  LEU A CB  1 
ATOM   127  C CG  . LEU A 1 17  ? 19.11126  10.35104  40.91142  1.000 21.05047 ? 17  LEU A CG  1 
ATOM   128  C CD1 . LEU A 1 17  ? 19.22882  11.61203  40.08410  1.000 22.62614 ? 17  LEU A CD1 1 
ATOM   129  C CD2 . LEU A 1 17  ? 18.20170  10.55962  42.12687  1.000 19.22233 ? 17  LEU A CD2 1 
ATOM   130  N N   . PRO A 1 18  ? 21.85862  8.61575   38.62967  1.000 10.83463 ? 18  PRO A N   1 
ATOM   131  C CA  . PRO A 1 18  ? 23.16681  8.16218   39.09536  1.000 10.52018 ? 18  PRO A CA  1 
ATOM   132  C C   . PRO A 1 18  ? 23.61029  8.93365   40.32747  1.000 21.04066 ? 18  PRO A C   1 
ATOM   133  O O   . PRO A 1 18  ? 23.30681  10.12055  40.49922  1.000 16.11455 ? 18  PRO A O   1 
ATOM   134  C CB  . PRO A 1 18  ? 24.08706  8.42629   37.89585  1.000 12.43577 ? 18  PRO A CB  1 
ATOM   135  C CG  . PRO A 1 18  ? 23.42327  9.56475   37.15465  1.000 14.91615 ? 18  PRO A CG  1 
ATOM   136  C CD  . PRO A 1 18  ? 21.93654  9.33097   37.33699  1.000 17.44101 ? 18  PRO A CD  1 
ATOM   137  N N   . ALA A 1 19  ? 24.31467  8.22253   41.21436  1.000 12.56336 ? 19  ALA A N   1 
ATOM   138  C CA  . ALA A 1 19  ? 24.82570  8.84512   42.42657  1.000 18.41949 ? 19  ALA A CA  1 
ATOM   139  C C   . ALA A 1 19  ? 25.73707  10.03214  42.14326  1.000 23.75264 ? 19  ALA A C   1 
ATOM   140  O O   . ALA A 1 19  ? 25.89700  10.89329  43.01530  1.000 26.65126 ? 19  ALA A O   1 
ATOM   141  C CB  . ALA A 1 19  ? 25.58817  7.81153   43.26022  1.000 23.92492 ? 19  ALA A CB  1 
ATOM   142  N N   . ASP A 1 20  ? 26.31750  10.10416  40.94248  1.000 25.46850 ? 20  ASP A N   1 
ATOM   143  C CA  . ASP A 1 20  ? 27.31178  11.12664  40.62453  1.000 44.25478 ? 20  ASP A CA  1 
ATOM   144  C C   . ASP A 1 20  ? 26.78908  12.55531  40.76209  1.000 46.73304 ? 20  ASP A C   1 
ATOM   145  O O   . ASP A 1 20  ? 27.59549  13.49083  40.79955  1.000 50.19135 ? 20  ASP A O   1 
ATOM   146  C CB  . ASP A 1 20  ? 27.85201  10.91700  39.20826  1.000 28.46599 ? 20  ASP A CB  1 
ATOM   147  C CG  . ASP A 1 20  ? 29.34099  11.14886  39.12812  1.000 49.98867 ? 20  ASP A CG  1 
ATOM   148  O OD1 . ASP A 1 20  ? 29.79751  12.25198  39.51711  1.000 48.04605 ? 20  ASP A OD1 1 
ATOM   149  O OD2 . ASP A 1 20  ? 30.05860  10.21440  38.70480  1.000 60.85877 ? 20  ASP A OD2 1 
ATOM   150  N N   . ARG A 1 21  ? 25.47449  12.75903  40.82690  1.000 48.26654 ? 21  ARG A N   1 
ATOM   151  C CA  . ARG A 1 21  ? 24.94263  14.07230  41.19738  1.000 58.84492 ? 21  ARG A CA  1 
ATOM   152  C C   . ARG A 1 21  ? 24.66377  14.06035  42.69322  1.000 60.21794 ? 21  ARG A C   1 
ATOM   153  O O   . ARG A 1 21  ? 23.55620  13.75900  43.13837  1.000 65.76039 ? 21  ARG A O   1 
ATOM   154  C CB  . ARG A 1 21  ? 23.69795  14.42527  40.39251  1.000 55.85183 ? 21  ARG A CB  1 
ATOM   155  C CG  . ARG A 1 21  ? 22.68375  13.31078  40.26425  1.000 46.58671 ? 21  ARG A CG  1 
ATOM   156  C CD  . ARG A 1 21  ? 22.69385  12.71370  38.87350  1.000 38.65894 ? 21  ARG A CD  1 
ATOM   157  N NE  . ARG A 1 21  ? 22.48810  13.70988  37.82977  1.000 60.90116 ? 21  ARG A NE  1 
ATOM   158  C CZ  . ARG A 1 21  ? 21.33612  14.32207  37.58235  1.000 61.10209 ? 21  ARG A CZ  1 
ATOM   159  N NH1 . ARG A 1 21  ? 20.27069  14.13344  38.34457  1.000 51.29977 ? 21  ARG A NH1 1 
ATOM   160  N NH2 . ARG A 1 21  ? 21.26477  15.18356  36.57229  1.000 70.66225 ? 21  ARG A NH2 1 
ATOM   161  N N   . LEU A 1 22  ? 25.69723  14.38425  43.47591  1.000 61.58999 ? 22  LEU A N   1 
ATOM   162  C CA  . LEU A 1 22  ? 25.57681  14.55687  44.91962  1.000 58.33163 ? 22  LEU A CA  1 
ATOM   163  C C   . LEU A 1 22  ? 25.21923  13.24301  45.60205  1.000 67.89059 ? 22  LEU A C   1 
ATOM   164  O O   . LEU A 1 22  ? 24.04663  12.85268  45.63545  1.000 74.24254 ? 22  LEU A O   1 
ATOM   165  C CB  . LEU A 1 22  ? 24.53310  15.63200  45.23834  1.000 61.96357 ? 22  LEU A CB  1 
ATOM   166  C CG  . LEU A 1 22  ? 24.23250  15.95637  46.69829  1.000 64.00008 ? 22  LEU A CG  1 
ATOM   167  C CD1 . LEU A 1 22  ? 25.03495  17.16977  47.16840  1.000 61.77989 ? 22  LEU A CD1 1 
ATOM   168  C CD2 . LEU A 1 22  ? 22.73490  16.14991  46.93061  1.000 59.51005 ? 22  LEU A CD2 1 
ATOM   169  N N   . VAL A 1 23  ? 26.21740  12.55031  46.15159  1.000 76.23069 ? 23  VAL A N   1 
ATOM   170  C CA  . VAL A 1 23  ? 25.96324  11.27614  46.81728  1.000 68.92889 ? 23  VAL A CA  1 
ATOM   171  C C   . VAL A 1 23  ? 25.97101  11.47033  48.32666  1.000 56.44539 ? 23  VAL A C   1 
ATOM   172  O O   . VAL A 1 23  ? 25.29383  10.73493  49.05447  1.000 67.75579 ? 23  VAL A O   1 
ATOM   173  C CB  . VAL A 1 23  ? 26.98113  10.19352  46.39624  1.000 66.35624 ? 23  VAL A CB  1 
ATOM   174  C CG1 . VAL A 1 23  ? 28.40442  10.56602  46.82930  1.000 64.75004 ? 23  VAL A CG1 1 
ATOM   175  C CG2 . VAL A 1 23  ? 26.57680  8.82221   46.95147  1.000 50.55592 ? 23  VAL A CG2 1 
ATOM   176  N N   . ILE A 1 24  ? 26.71295  12.46548  48.81598  1.000 58.12706 ? 24  ILE A N   1 
ATOM   177  C CA  . ILE A 1 24  ? 26.94132  12.48441  50.25261  1.000 59.20534 ? 24  ILE A CA  1 
ATOM   178  C C   . ILE A 1 24  ? 27.58957  13.75304  50.80038  1.000 53.31765 ? 24  ILE A C   1 
ATOM   179  O O   . ILE A 1 24  ? 28.66595  14.16546  50.35371  1.000 54.23515 ? 24  ILE A O   1 
ATOM   180  C CB  . ILE A 1 24  ? 27.79109  11.27478  50.62787  1.000 52.24426 ? 24  ILE A CB  1 
ATOM   181  N N   . ASP A 1 25  ? 26.91407  14.38603  51.75773  1.000 47.77505 ? 25  ASP A N   1 
ATOM   182  C CA  . ASP A 1 25  ? 27.61603  15.04486  52.84469  1.000 42.30618 ? 25  ASP A CA  1 
ATOM   183  C C   . ASP A 1 25  ? 28.02950  13.97890  53.86029  1.000 40.55421 ? 25  ASP A C   1 
ATOM   184  O O   . ASP A 1 25  ? 27.75387  12.78837  53.68851  1.000 48.47716 ? 25  ASP A O   1 
ATOM   185  C CB  . ASP A 1 25  ? 26.75269  16.13703  53.47354  1.000 45.72315 ? 25  ASP A CB  1 
ATOM   186  C CG  . ASP A 1 25  ? 25.46399  15.60546  54.08693  1.000 45.72020 ? 25  ASP A CG  1 
ATOM   187  O OD1 . ASP A 1 25  ? 25.52087  14.79747  55.03884  1.000 39.15423 ? 25  ASP A OD1 1 
ATOM   188  O OD2 . ASP A 1 25  ? 24.38088  16.02974  53.63220  1.000 53.23784 ? 25  ASP A OD2 1 
ATOM   189  N N   . ALA A 1 26  ? 28.68424  14.40307  54.94402  1.000 51.16288 ? 26  ALA A N   1 
ATOM   190  C CA  . ALA A 1 26  ? 29.28127  13.44571  55.87328  1.000 40.04638 ? 26  ALA A CA  1 
ATOM   191  C C   . ALA A 1 26  ? 28.22550  12.55930  56.52656  1.000 36.45731 ? 26  ALA A C   1 
ATOM   192  O O   . ALA A 1 26  ? 28.37664  11.33383  56.58677  1.000 39.82980 ? 26  ALA A O   1 
ATOM   193  C CB  . ALA A 1 26  ? 30.08979  14.18562  56.94051  1.000 43.69824 ? 26  ALA A CB  1 
ATOM   194  N N   . GLU A 1 27  ? 27.15178  13.16361  57.03340  1.000 42.04168 ? 27  GLU A N   1 
ATOM   195  C CA  . GLU A 1 27  ? 26.15049  12.39832  57.76722  1.000 31.88645 ? 27  GLU A CA  1 
ATOM   196  C C   . GLU A 1 27  ? 25.38518  11.46197  56.84402  1.000 34.04697 ? 27  GLU A C   1 
ATOM   197  O O   . GLU A 1 27  ? 25.08477  10.31906  57.21475  1.000 29.56717 ? 27  GLU A O   1 
ATOM   198  C CB  . GLU A 1 27  ? 25.19531  13.35072  58.47707  1.000 37.88087 ? 27  GLU A CB  1 
ATOM   199  C CG  . GLU A 1 27  ? 23.94756  12.69749  59.02998  1.000 40.23285 ? 27  GLU A CG  1 
ATOM   200  C CD  . GLU A 1 27  ? 22.99564  13.71141  59.63915  1.000 60.47517 ? 27  GLU A CD  1 
ATOM   201  O OE1 . GLU A 1 27  ? 23.46815  14.56932  60.41642  1.000 54.41624 ? 27  GLU A OE1 1 
ATOM   202  O OE2 . GLU A 1 27  ? 21.78305  13.65978  59.32790  1.000 60.85287 ? 27  GLU A OE2 1 
ATOM   203  N N   . LEU A 1 28  ? 25.05824  11.93570  55.64309  1.000 34.64214 ? 28  LEU A N   1 
ATOM   204  C CA  . LEU A 1 28  ? 24.37581  11.09259  54.67211  1.000 36.33934 ? 28  LEU A CA  1 
ATOM   205  C C   . LEU A 1 28  ? 25.25208  9.91642   54.27475  1.000 29.19134 ? 28  LEU A C   1 
ATOM   206  O O   . LEU A 1 28  ? 24.80782  8.76601   54.30260  1.000 18.90501 ? 28  LEU A O   1 
ATOM   207  C CB  . LEU A 1 28  ? 23.98691  11.91499  53.44830  1.000 22.96753 ? 28  LEU A CB  1 
ATOM   208  C CG  . LEU A 1 28  ? 23.23145  11.14729  52.36213  1.000 35.09938 ? 28  LEU A CG  1 
ATOM   209  C CD1 . LEU A 1 28  ? 21.99296  10.44584  52.92295  1.000 25.38727 ? 28  LEU A CD1 1 
ATOM   210  C CD2 . LEU A 1 28  ? 22.84716  12.08321  51.24239  1.000 37.29773 ? 28  LEU A CD2 1 
ATOM   211  N N   . ARG A 1 29  ? 26.51144  10.19355  53.92064  1.000 27.21736 ? 29  ARG A N   1 
ATOM   212  C CA  . ARG A 1 29  ? 27.45618  9.13760   53.57450  1.000 26.86781 ? 29  ARG A CA  1 
ATOM   213  C C   . ARG A 1 29  ? 27.50020  8.05887   54.64356  1.000 24.72205 ? 29  ARG A C   1 
ATOM   214  O O   . ARG A 1 29  ? 27.53768  6.86008   54.33391  1.000 20.00705 ? 29  ARG A O   1 
ATOM   215  C CB  . ARG A 1 29  ? 28.85222  9.72731   53.38952  1.000 27.86433 ? 29  ARG A CB  1 
ATOM   216  C CG  . ARG A 1 29  ? 29.82085  8.80203   52.68130  1.000 31.52440 ? 29  ARG A CG  1 
ATOM   217  C CD  . ARG A 1 29  ? 31.17627  9.47276   52.50357  1.000 54.60936 ? 29  ARG A CD  1 
ATOM   218  N NE  . ARG A 1 29  ? 31.07102  10.85356  52.03942  1.000 58.01090 ? 29  ARG A NE  1 
ATOM   219  C CZ  . ARG A 1 29  ? 31.03612  11.22206  50.76348  1.000 63.18663 ? 29  ARG A CZ  1 
ATOM   220  N NH1 . ARG A 1 29  ? 31.06434  10.33182  49.78096  1.000 53.86870 ? 29  ARG A NH1 1 
ATOM   221  N NH2 . ARG A 1 29  ? 30.94925  12.51598  50.46428  1.000 58.25770 ? 29  ARG A NH2 1 
ATOM   222  N N   . GLN A 1 30  ? 27.50558  8.47123   55.91258  1.000 25.93509 ? 30  GLN A N   1 
ATOM   223  C CA  . GLN A 1 30  ? 27.57059  7.51004   57.00420  1.000 21.37767 ? 30  GLN A CA  1 
ATOM   224  C C   . GLN A 1 30  ? 26.32300  6.63748   57.04089  1.000 23.33156 ? 30  GLN A C   1 
ATOM   225  O O   . GLN A 1 30  ? 26.41035  5.41827   57.22726  1.000 15.19891 ? 30  GLN A O   1 
ATOM   226  C CB  . GLN A 1 30  ? 27.75058  8.24895   58.32945  1.000 25.01146 ? 30  GLN A CB  1 
ATOM   227  C CG  . GLN A 1 30  ? 27.77700  7.33739   59.53194  1.000 40.19754 ? 30  GLN A CG  1 
ATOM   228  C CD  . GLN A 1 30  ? 28.84247  6.25933   59.40579  1.000 51.15689 ? 30  GLN A CD  1 
ATOM   229  O OE1 . GLN A 1 30  ? 29.90116  6.48641   58.80556  1.000 44.30772 ? 30  GLN A OE1 1 
ATOM   230  N NE2 . GLN A 1 30  ? 28.56538  5.07457   59.96566  1.000 37.41932 ? 30  GLN A NE2 1 
ATOM   231  N N   . HIS A 1 31  ? 25.14814  7.24082   56.86154  1.000 22.56879 ? 31  HIS A N   1 
ATOM   232  C CA  . HIS A 1 31  ? 23.93313  6.43428   56.85888  1.000 18.55613 ? 31  HIS A CA  1 
ATOM   233  C C   . HIS A 1 31  ? 23.87607  5.50594   55.64980  1.000 12.76628 ? 31  HIS A C   1 
ATOM   234  O O   . HIS A 1 31  ? 23.34835  4.39393   55.75359  1.000 14.10175 ? 31  HIS A O   1 
ATOM   235  C CB  . HIS A 1 31  ? 22.70870  7.33947   56.90830  1.000 18.08564 ? 31  HIS A CB  1 
ATOM   236  C CG  . HIS A 1 31  ? 22.54898  8.06344   58.21015  1.000 20.14921 ? 31  HIS A CG  1 
ATOM   237  N ND1 . HIS A 1 31  ? 22.72652  7.45286   59.43220  1.000 24.78176 ? 31  HIS A ND1 1 
ATOM   238  C CD2 . HIS A 1 31  ? 22.22973  9.35117   58.48114  1.000 32.41155 ? 31  HIS A CD2 1 
ATOM   239  C CE1 . HIS A 1 31  ? 22.51929  8.32972   60.39769  1.000 26.65747 ? 31  HIS A CE1 1 
ATOM   240  N NE2 . HIS A 1 31  ? 22.21676  9.49207   59.84651  1.000 22.13543 ? 31  HIS A NE2 1 
ATOM   241  N N   . VAL A 1 32  ? 24.39251  5.94191   54.50010  1.000 13.69740 ? 32  VAL A N   1 
ATOM   242  C CA  . VAL A 1 32  ? 24.50612  5.04281   53.35164  1.000 14.86433 ? 32  VAL A CA  1 
ATOM   243  C C   . VAL A 1 32  ? 25.35991  3.83416   53.71155  1.000 10.94425 ? 32  VAL A C   1 
ATOM   244  O O   . VAL A 1 32  ? 24.99858  2.69206   53.42103  1.000 12.10226 ? 32  VAL A O   1 
ATOM   245  C CB  . VAL A 1 32  ? 25.08052  5.78053   52.12764  1.000 15.67518 ? 32  VAL A CB  1 
ATOM   246  C CG1 . VAL A 1 32  ? 25.15988  4.81882   50.92905  1.000 15.99206 ? 32  VAL A CG1 1 
ATOM   247  C CG2 . VAL A 1 32  ? 24.21930  7.00141   51.77027  1.000 17.48675 ? 32  VAL A CG2 1 
ATOM   248  N N   . LYS A 1 33  ? 26.51499  4.06893   54.33749  1.000 14.02557 ? 33  LYS A N   1 
ATOM   249  C CA  . LYS A 1 33  ? 27.39909  2.95815   54.68217  1.000 17.34360 ? 33  LYS A CA  1 
ATOM   250  C C   . LYS A 1 33  ? 26.73194  2.00048   55.65309  1.000 15.16894 ? 33  LYS A C   1 
ATOM   251  O O   . LYS A 1 33  ? 26.78064  0.78027   55.46331  1.000 17.14496 ? 33  LYS A O   1 
ATOM   252  C CB  . LYS A 1 33  ? 28.70834  3.48036   55.26569  1.000 19.04560 ? 33  LYS A CB  1 
ATOM   253  C CG  . LYS A 1 33  ? 29.53344  4.23307   54.26169  1.000 25.53853 ? 33  LYS A CG  1 
ATOM   254  C CD  . LYS A 1 33  ? 29.64279  3.46267   52.95907  1.000 30.42948 ? 33  LYS A CD  1 
ATOM   255  C CE  . LYS A 1 33  ? 29.93470  4.40112   51.81270  1.000 35.27157 ? 33  LYS A CE  1 
ATOM   256  N NZ  . LYS A 1 33  ? 30.16550  3.65600   50.55492  1.000 32.91612 ? 33  LYS A NZ  1 
ATOM   257  N N   . GLU A 1 34  ? 26.08873  2.53836   56.69675  1.000 18.62199 ? 34  GLU A N   1 
ATOM   258  C CA  . GLU A 1 34  ? 25.35283  1.70531   57.64285  1.000 15.01123 ? 34  GLU A CA  1 
ATOM   259  C C   . GLU A 1 34  ? 24.28087  0.87780   56.94191  1.000 17.05812 ? 34  GLU A C   1 
ATOM   260  O O   . GLU A 1 34  ? 24.12879  -0.32047  57.21237  1.000 12.78743 ? 34  GLU A O   1 
ATOM   261  C CB  . GLU A 1 34  ? 24.70430  2.57846   58.71896  1.000 24.88633 ? 34  GLU A CB  1 
ATOM   262  C CG  . GLU A 1 34  ? 25.64000  3.16177   59.75238  1.000 24.96973 ? 34  GLU A CG  1 
ATOM   263  C CD  . GLU A 1 34  ? 25.05365  4.39503   60.41433  1.000 40.16489 ? 34  GLU A CD  1 
ATOM   264  O OE1 . GLU A 1 34  ? 23.86196  4.70924   60.15915  1.000 29.43469 ? 34  GLU A OE1 1 
ATOM   265  O OE2 . GLU A 1 34  ? 25.78751  5.05729   61.17467  1.000 29.47479 ? 34  GLU A OE2 1 
ATOM   266  N N   . LEU A 1 35  ? 23.50174  1.51093   56.05890  1.000 15.51472 ? 35  LEU A N   1 
ATOM   267  C CA  . LEU A 1 35  ? 22.44884  0.78423   55.36631  1.000 8.60121  ? 35  LEU A CA  1 
ATOM   268  C C   . LEU A 1 35  ? 23.03556  -0.31678  54.49818  1.000 7.50980  ? 35  LEU A C   1 
ATOM   269  O O   . LEU A 1 35  ? 22.61826  -1.46873  54.58753  1.000 10.40740 ? 35  LEU A O   1 
ATOM   270  C CB  . LEU A 1 35  ? 21.58939  1.74473   54.52197  1.000 10.67339 ? 35  LEU A CB  1 
ATOM   271  C CG  . LEU A 1 35  ? 20.37431  1.11485   53.81861  1.000 11.36324 ? 35  LEU A CG  1 
ATOM   272  C CD1 . LEU A 1 35  ? 19.45724  0.34906   54.79074  1.000 9.09222  ? 35  LEU A CD1 1 
ATOM   273  C CD2 . LEU A 1 35  ? 19.55103  2.16112   53.02949  1.000 10.71194 ? 35  LEU A CD2 1 
ATOM   274  N N   . ALA A 1 36  ? 24.00287  0.01923   53.64074  1.000 13.34257 ? 36  ALA A N   1 
ATOM   275  C CA  . ALA A 1 36  ? 24.55219  -0.98490  52.72802  1.000 10.29639 ? 36  ALA A CA  1 
ATOM   276  C C   . ALA A 1 36  ? 25.17586  -2.15162  53.48620  1.000 13.66725 ? 36  ALA A C   1 
ATOM   277  O O   . ALA A 1 36  ? 25.12145  -3.29227  53.01573  1.000 13.56951 ? 36  ALA A O   1 
ATOM   278  C CB  . ALA A 1 36  ? 25.58890  -0.35678  51.80282  1.000 7.68848  ? 36  ALA A CB  1 
ATOM   279  N N   . ALA A 1 37  ? 25.73515  -1.89361  54.67508  1.000 15.35617 ? 37  ALA A N   1 
ATOM   280  C CA  . ALA A 1 37  ? 26.36262  -2.96071  55.45407  1.000 18.98092 ? 37  ALA A CA  1 
ATOM   281  C C   . ALA A 1 37  ? 25.36338  -4.03055  55.86491  1.000 19.86727 ? 37  ALA A C   1 
ATOM   282  O O   . ALA A 1 37  ? 25.75178  -5.17595  56.13049  1.000 14.82528 ? 37  ALA A O   1 
ATOM   283  C CB  . ALA A 1 37  ? 27.03875  -2.37572  56.69193  1.000 16.43854 ? 37  ALA A CB  1 
ATOM   284  N N   . GLU A 1 38  ? 24.07096  -3.68348  55.91134  1.000 11.75770 ? 38  GLU A N   1 
ATOM   285  C CA  . GLU A 1 38  ? 23.04656  -4.64537  56.29809  1.000 12.99041 ? 38  GLU A CA  1 
ATOM   286  C C   . GLU A 1 38  ? 22.97551  -5.81719  55.34786  1.000 13.90942 ? 38  GLU A C   1 
ATOM   287  O O   . GLU A 1 38  ? 22.51734  -6.90155  55.73915  1.000 17.09615 ? 38  GLU A O   1 
ATOM   288  C CB  . GLU A 1 38  ? 21.67482  -3.97600  56.34460  1.000 13.91611 ? 38  GLU A CB  1 
ATOM   289  C CG  . GLU A 1 38  ? 21.61650  -2.80127  57.26629  1.000 14.26163 ? 38  GLU A CG  1 
ATOM   290  C CD  . GLU A 1 38  ? 21.52754  -3.22513  58.71023  1.000 16.52450 ? 38  GLU A CD  1 
ATOM   291  O OE1 . GLU A 1 38  ? 21.10448  -4.37511  58.97962  1.000 19.18027 ? 38  GLU A OE1 1 
ATOM   292  O OE2 . GLU A 1 38  ? 21.87675  -2.40058  59.57303  1.000 22.19180 ? 38  GLU A OE2 1 
ATOM   293  N N   . TRP A 1 39  ? 23.40254  -5.62412  54.09579  1.000 9.99078  ? 39  TRP A N   1 
ATOM   294  C CA  . TRP A 1 39  ? 23.34265  -6.70212  53.11794  1.000 15.70132 ? 39  TRP A CA  1 
ATOM   295  C C   . TRP A 1 39  ? 24.32854  -7.83321  53.42482  1.000 16.92015 ? 39  TRP A C   1 
ATOM   296  O O   . TRP A 1 39  ? 24.21334  -8.90136  52.81809  1.000 13.71864 ? 39  TRP A O   1 
ATOM   297  C CB  . TRP A 1 39  ? 23.59896  -6.15365  51.69963  1.000 17.19119 ? 39  TRP A CB  1 
ATOM   298  C CG  . TRP A 1 39  ? 22.34562  -5.65545  51.00758  1.000 9.49250  ? 39  TRP A CG  1 
ATOM   299  C CD1 . TRP A 1 39  ? 21.71635  -6.22672  49.95381  1.000 8.79993  ? 39  TRP A CD1 1 
ATOM   300  C CD2 . TRP A 1 39  ? 21.57585  -4.49534  51.35140  1.000 10.22055 ? 39  TRP A CD2 1 
ATOM   301  N NE1 . TRP A 1 39  ? 20.60797  -5.49047  49.59466  1.000 7.48857  ? 39  TRP A NE1 1 
ATOM   302  C CE2 . TRP A 1 39  ? 20.49164  -4.42832  50.44802  1.000 11.74516 ? 39  TRP A CE2 1 
ATOM   303  C CE3 . TRP A 1 39  ? 21.69891  -3.50386  52.32981  1.000 8.42435  ? 39  TRP A CE3 1 
ATOM   304  C CZ2 . TRP A 1 39  ? 19.52614  -3.40780  50.50252  1.000 7.95046  ? 39  TRP A CZ2 1 
ATOM   305  C CZ3 . TRP A 1 39  ? 20.73009  -2.48043  52.38455  1.000 10.27361 ? 39  TRP A CZ3 1 
ATOM   306  C CH2 . TRP A 1 39  ? 19.67084  -2.44630  51.48421  1.000 5.70451  ? 39  TRP A CH2 1 
ATOM   307  N N   . GLU A 1 40  ? 25.29109  -7.62324  54.33412  1.000 16.96865 ? 40  GLU A N   1 
ATOM   308  C CA  . GLU A 1 40  ? 26.17203  -8.69211  54.80116  1.000 23.96361 ? 40  GLU A CA  1 
ATOM   309  C C   . GLU A 1 40  ? 25.49699  -9.61543  55.81467  1.000 28.08478 ? 40  GLU A C   1 
ATOM   310  O O   . GLU A 1 40  ? 26.05311  -10.67330 56.13781  1.000 22.44754 ? 40  GLU A O   1 
ATOM   311  C CB  . GLU A 1 40  ? 27.44109  -8.11119  55.44350  1.000 18.61572 ? 40  GLU A CB  1 
ATOM   312  C CG  . GLU A 1 40  ? 28.26632  -7.17594  54.56618  1.000 20.18925 ? 40  GLU A CG  1 
ATOM   313  C CD  . GLU A 1 40  ? 28.89924  -7.87277  53.36783  1.000 21.46009 ? 40  GLU A CD  1 
ATOM   314  O OE1 . GLU A 1 40  ? 29.00618  -9.11362  53.38185  1.000 27.59083 ? 40  GLU A OE1 1 
ATOM   315  O OE2 . GLU A 1 40  ? 29.29127  -7.18023  52.39907  1.000 25.60827 ? 40  GLU A OE2 1 
ATOM   316  N N   . ASN A 1 41  ? 24.32652  -9.23880  56.33393  1.000 21.93290 ? 41  ASN A N   1 
ATOM   317  C CA  . ASN A 1 41  ? 23.68719  -9.96235  57.42406  1.000 18.61343 ? 41  ASN A CA  1 
ATOM   318  C C   . ASN A 1 41  ? 22.28653  -10.42979 57.05165  1.000 20.31327 ? 41  ASN A C   1 
ATOM   319  O O   . ASN A 1 41  ? 21.40506  -10.48497 57.90817  1.000 25.41288 ? 41  ASN A O   1 
ATOM   320  C CB  . ASN A 1 41  ? 23.63931  -9.09926  58.68267  1.000 18.59051 ? 41  ASN A CB  1 
ATOM   321  C CG  . ASN A 1 41  ? 25.01231  -8.64975  59.13076  1.000 26.24911 ? 41  ASN A CG  1 
ATOM   322  O OD1 . ASN A 1 41  ? 25.95233  -9.42998  59.15129  1.000 31.50013 ? 41  ASN A OD1 1 
ATOM   323  N ND2 . ASN A 1 41  ? 25.13359  -7.37320  59.48930  1.000 36.45654 ? 41  ASN A ND2 1 
ATOM   324  N N   . LEU A 1 42  ? 22.06766  -10.75948 55.78203  1.000 14.65160 ? 42  LEU A N   1 
ATOM   325  C CA  . LEU A 1 42  ? 20.78226  -11.27259 55.32614  1.000 21.77123 ? 42  LEU A CA  1 
ATOM   326  C C   . LEU A 1 42  ? 20.68233  -12.77961 55.54250  1.000 27.68407 ? 42  LEU A C   1 
ATOM   327  O O   . LEU A 1 42  ? 21.67561  -13.50759 55.45766  1.000 31.80312 ? 42  LEU A O   1 
ATOM   328  C CB  . LEU A 1 42  ? 20.56406  -10.94752 53.84628  1.000 19.52609 ? 42  LEU A CB  1 
ATOM   329  C CG  . LEU A 1 42  ? 20.44101  -9.44856  53.57328  1.000 19.70695 ? 42  LEU A CG  1 
ATOM   330  C CD1 . LEU A 1 42  ? 20.33819  -9.14409  52.07253  1.000 11.92467 ? 42  LEU A CD1 1 
ATOM   331  C CD2 . LEU A 1 42  ? 19.25133  -8.86155  54.36196  1.000 19.42574 ? 42  LEU A CD2 1 
ATOM   332  N N   . GLU A 1 43  ? 19.46116  -13.23689 55.82404  1.000 38.30804 ? 43  GLU A N   1 
ATOM   333  C CA  . GLU A 1 43  ? 19.18707  -14.66208 55.98507  1.000 34.58380 ? 43  GLU A CA  1 
ATOM   334  C C   . GLU A 1 43  ? 19.54754  -15.41193 54.71065  1.000 41.33997 ? 43  GLU A C   1 
ATOM   335  O O   . GLU A 1 43  ? 19.08584  -15.06266 53.62096  1.000 38.80352 ? 43  GLU A O   1 
ATOM   336  C CB  . GLU A 1 43  ? 17.71142  -14.87072 56.31398  1.000 42.14760 ? 43  GLU A CB  1 
ATOM   337  C CG  . GLU A 1 43  ? 17.35441  -16.27818 56.73649  1.000 51.66997 ? 43  GLU A CG  1 
ATOM   338  C CD  . GLU A 1 43  ? 17.97339  -16.64528 58.07449  1.000 45.49449 ? 43  GLU A CD  1 
ATOM   339  O OE1 . GLU A 1 43  ? 17.90695  -15.82225 59.01679  1.000 37.61849 ? 43  GLU A OE1 1 
ATOM   340  O OE2 . GLU A 1 43  ? 18.53478  -17.75422 58.18069  1.000 45.59723 ? 43  GLU A OE2 1 
ATOM   341  N N   . THR A 1 44  ? 20.37786  -16.44258 54.84330  1.000 50.69739 ? 44  THR A N   1 
ATOM   342  C CA  . THR A 1 44  ? 20.91260  -17.13231 53.67777  1.000 44.87097 ? 44  THR A CA  1 
ATOM   343  C C   . THR A 1 44  ? 19.94529  -18.21251 53.21101  1.000 48.54328 ? 44  THR A C   1 
ATOM   344  O O   . THR A 1 44  ? 19.25350  -18.83768 54.01986  1.000 61.40341 ? 44  THR A O   1 
ATOM   345  C CB  . THR A 1 44  ? 22.29115  -17.72878 53.98496  1.000 56.56375 ? 44  THR A CB  1 
ATOM   346  O OG1 . THR A 1 44  ? 22.90227  -18.17651 52.76963  1.000 54.43193 ? 44  THR A OG1 1 
ATOM   347  C CG2 . THR A 1 44  ? 22.19375  -18.89781 54.97025  1.000 59.14765 ? 44  THR A CG2 1 
ATOM   348  N N   . ASP A 1 45  ? 19.86902  -18.39416 51.89373  1.000 64.14129 ? 45  ASP A N   1 
ATOM   349  C CA  . ASP A 1 45  ? 18.99912  -19.40865 51.29404  1.000 66.33598 ? 45  ASP A CA  1 
ATOM   350  C C   . ASP A 1 45  ? 19.79611  -20.27282 50.32481  1.000 66.59619 ? 45  ASP A C   1 
ATOM   351  O O   . ASP A 1 45  ? 20.19581  -19.80656 49.25460  1.000 65.85018 ? 45  ASP A O   1 
ATOM   352  C CB  . ASP A 1 45  ? 17.81655  -18.76666 50.55839  1.000 54.87381 ? 45  ASP A CB  1 
ATOM   353  C CG  . ASP A 1 45  ? 17.18882  -17.62382 51.33567  1.000 60.04023 ? 45  ASP A CG  1 
ATOM   354  O OD1 . ASP A 1 45  ? 17.11686  -17.70302 52.58438  1.000 57.78310 ? 45  ASP A OD1 1 
ATOM   355  O OD2 . ASP A 1 45  ? 16.76473  -16.63823 50.69134  1.000 57.38799 ? 45  ASP A OD2 1 
ATOM   356  N N   . ARG A 1 53  ? 21.50941  -18.61053 41.30427  1.000 62.77969 ? 53  ARG A N   1 
ATOM   357  C CA  . ARG A 1 53  ? 22.35417  -19.51084 42.07698  1.000 61.26253 ? 53  ARG A CA  1 
ATOM   358  C C   . ARG A 1 53  ? 22.14585  -19.29661 43.57012  1.000 60.75948 ? 53  ARG A C   1 
ATOM   359  O O   . ARG A 1 53  ? 22.06873  -20.25433 44.34139  1.000 78.35758 ? 53  ARG A O   1 
ATOM   360  C CB  . ARG A 1 53  ? 23.83008  -19.31129 41.69910  1.000 55.95876 ? 53  ARG A CB  1 
ATOM   361  C CG  . ARG A 1 53  ? 24.85104  -19.89375 42.67794  1.000 48.76617 ? 53  ARG A CG  1 
ATOM   362  C CD  . ARG A 1 53  ? 24.64333  -21.39321 42.91303  1.000 64.80989 ? 53  ARG A CD  1 
ATOM   363  N NE  . ARG A 1 53  ? 24.75673  -22.19291 41.69653  1.000 80.36407 ? 53  ARG A NE  1 
ATOM   364  C CZ  . ARG A 1 53  ? 24.34185  -23.44917 41.58048  1.000 76.66564 ? 53  ARG A CZ  1 
ATOM   365  N NH1 . ARG A 1 53  ? 23.74191  -24.07451 42.58046  1.000 60.23142 ? 53  ARG A NH1 1 
ATOM   366  N NH2 . ARG A 1 53  ? 24.54031  -24.09557 40.43347  1.000 77.25709 ? 53  ARG A NH2 1 
ATOM   367  N N   . PHE A 1 54  ? 22.03263  -18.03792 43.97878  1.000 42.92521 ? 54  PHE A N   1 
ATOM   368  C CA  . PHE A 1 54  ? 22.10778  -17.70889 45.39824  1.000 44.71844 ? 54  PHE A CA  1 
ATOM   369  C C   . PHE A 1 54  ? 21.52447  -16.31287 45.59571  1.000 41.70082 ? 54  PHE A C   1 
ATOM   370  O O   . PHE A 1 54  ? 21.95744  -15.35326 44.94456  1.000 31.42643 ? 54  PHE A O   1 
ATOM   371  C CB  . PHE A 1 54  ? 23.56889  -17.79606 45.85476  1.000 48.88959 ? 54  PHE A CB  1 
ATOM   372  C CG  . PHE A 1 54  ? 23.76007  -18.03760 47.33079  1.000 48.56061 ? 54  PHE A CG  1 
ATOM   373  C CD1 . PHE A 1 54  ? 22.71728  -17.88813 48.23209  1.000 53.36249 ? 54  PHE A CD1 1 
ATOM   374  C CD2 . PHE A 1 54  ? 25.01352  -18.39550 47.81624  1.000 46.59058 ? 54  PHE A CD2 1 
ATOM   375  C CE1 . PHE A 1 54  ? 22.92171  -18.10391 49.59890  1.000 53.41283 ? 54  PHE A CE1 1 
ATOM   376  C CE2 . PHE A 1 54  ? 25.22274  -18.61111 49.17309  1.000 59.86056 ? 54  PHE A CE2 1 
ATOM   377  C CZ  . PHE A 1 54  ? 24.17788  -18.46437 50.06498  1.000 48.32474 ? 54  PHE A CZ  1 
ATOM   378  N N   . ARG A 1 55  ? 20.52724  -16.19725 46.46814  1.000 34.70435 ? 55  ARG A N   1 
ATOM   379  C CA  . ARG A 1 55  ? 19.82623  -14.93892 46.67715  1.000 26.07559 ? 55  ARG A CA  1 
ATOM   380  C C   . ARG A 1 55  ? 19.48287  -14.81281 48.15239  1.000 33.63713 ? 55  ARG A C   1 
ATOM   381  O O   . ARG A 1 55  ? 18.74535  -15.64008 48.69442  1.000 43.85700 ? 55  ARG A O   1 
ATOM   382  C CB  . ARG A 1 55  ? 18.56529  -14.86973 45.81435  1.000 34.21937 ? 55  ARG A CB  1 
ATOM   383  C CG  . ARG A 1 55  ? 17.85909  -13.52489 45.89634  1.000 49.41365 ? 55  ARG A CG  1 
ATOM   384  C CD  . ARG A 1 55  ? 16.63886  -13.46036 44.98368  1.000 57.84565 ? 55  ARG A CD  1 
ATOM   385  N NE  . ARG A 1 55  ? 15.52985  -14.26345 45.48671  1.000 64.38797 ? 55  ARG A NE  1 
ATOM   386  C CZ  . ARG A 1 55  ? 14.29360  -14.21839 45.00536  1.000 61.09742 ? 55  ARG A CZ  1 
ATOM   387  N NH1 . ARG A 1 55  ? 13.96879  -13.41648 44.00151  1.000 51.30731 ? 55  ARG A NH1 1 
ATOM   388  N NH2 . ARG A 1 55  ? 13.35776  -14.99327 45.54741  1.000 62.97992 ? 55  ARG A NH2 1 
ATOM   389  N N   . GLU A 1 56  ? 20.01962  -13.79520 48.80742  1.000 20.55358 ? 56  GLU A N   1 
ATOM   390  C CA  . GLU A 1 56  ? 19.72026  -13.54558 50.20878  1.000 22.36421 ? 56  GLU A CA  1 
ATOM   391  C C   . GLU A 1 56  ? 18.82981  -12.31647 50.31222  1.000 24.05621 ? 56  GLU A C   1 
ATOM   392  O O   . GLU A 1 56  ? 19.05108  -11.32375 49.60758  1.000 22.38549 ? 56  GLU A O   1 
ATOM   393  C CB  . GLU A 1 56  ? 21.00511  -13.36376 51.00837  1.000 23.39689 ? 56  GLU A CB  1 
ATOM   394  C CG  . GLU A 1 56  ? 21.97545  -14.51254 50.82061  1.000 33.13863 ? 56  GLU A CG  1 
ATOM   395  C CD  . GLU A 1 56  ? 23.25832  -14.31069 51.57611  1.000 25.97600 ? 56  GLU A CD  1 
ATOM   396  O OE1 . GLU A 1 56  ? 23.64984  -13.14234 51.77291  1.000 31.42488 ? 56  GLU A OE1 1 
ATOM   397  O OE2 . GLU A 1 56  ? 23.87239  -15.31828 51.97717  1.000 34.00914 ? 56  GLU A OE2 1 
ATOM   398  N N   . ARG A 1 57  ? 17.81191  -12.38406 51.17258  1.000 19.57788 ? 57  ARG A N   1 
ATOM   399  C CA  . ARG A 1 57  ? 16.78626  -11.36198 51.11806  1.000 18.00535 ? 57  ARG A CA  1 
ATOM   400  C C   . ARG A 1 57  ? 16.14663  -11.13459 52.47590  1.000 18.69585 ? 57  ARG A C   1 
ATOM   401  O O   . ARG A 1 57  ? 16.19595  -11.97734 53.37767  1.000 18.97785 ? 57  ARG A O   1 
ATOM   402  C CB  . ARG A 1 57  ? 15.72271  -11.70301 50.07040  1.000 24.48844 ? 57  ARG A CB  1 
ATOM   403  C CG  . ARG A 1 57  ? 14.99221  -12.98521 50.31982  1.000 30.19155 ? 57  ARG A CG  1 
ATOM   404  C CD  . ARG A 1 57  ? 14.07500  -13.33849 49.15977  1.000 44.48467 ? 57  ARG A CD  1 
ATOM   405  N NE  . ARG A 1 57  ? 14.65077  -14.36929 48.30397  1.000 57.44280 ? 57  ARG A NE  1 
ATOM   406  C CZ  . ARG A 1 57  ? 14.79523  -15.64636 48.64415  1.000 59.13446 ? 57  ARG A CZ  1 
ATOM   407  N NH1 . ARG A 1 57  ? 14.45442  -16.09177 49.84780  1.000 51.48928 ? 57  ARG A NH1 1 
ATOM   408  N NH2 . ARG A 1 57  ? 15.30034  -16.49978 47.75636  1.000 48.66031 ? 57  ARG A NH2 1 
ATOM   409  N N   . ALA A 1 58  ? 15.59578  -9.93342  52.60624  1.000 12.30461 ? 58  ALA A N   1 
ATOM   410  C CA  . ALA A 1 58  ? 14.76423  -9.50245  53.71942  1.000 13.74771 ? 58  ALA A CA  1 
ATOM   411  C C   . ALA A 1 58  ? 13.64894  -8.64505  53.13769  1.000 15.82467 ? 58  ALA A C   1 
ATOM   412  O O   . ALA A 1 58  ? 13.76638  -8.13263  52.01964  1.000 12.79739 ? 58  ALA A O   1 
ATOM   413  C CB  . ALA A 1 58  ? 15.56526  -8.72323  54.75442  1.000 9.69091  ? 58  ALA A CB  1 
ATOM   414  N N   . TYR A 1 59  ? 12.56856  -8.47741  53.89864  1.000 11.62691 ? 59  TYR A N   1 
ATOM   415  C CA  . TYR A 1 59  ? 11.36781  -7.86174  53.35087  1.000 12.61236 ? 59  TYR A CA  1 
ATOM   416  C C   . TYR A 1 59  ? 10.53817  -7.26430  54.47754  1.000 20.33987 ? 59  TYR A C   1 
ATOM   417  O O   . TYR A 1 59  ? 10.49751  -7.80899  55.58051  1.000 16.78579 ? 59  TYR A O   1 
ATOM   418  C CB  . TYR A 1 59  ? 10.55164  -8.90518  52.59052  1.000 13.96242 ? 59  TYR A CB  1 
ATOM   419  C CG  . TYR A 1 59  ? 9.18190   -8.51157  52.08006  1.000 18.34312 ? 59  TYR A CG  1 
ATOM   420  C CD1 . TYR A 1 59  ? 9.03020   -7.91020  50.83566  1.000 23.50848 ? 59  TYR A CD1 1 
ATOM   421  C CD2 . TYR A 1 59  ? 8.02987   -8.80887  52.81112  1.000 22.31637 ? 59  TYR A CD2 1 
ATOM   422  C CE1 . TYR A 1 59  ? 7.77103   -7.58620  50.34679  1.000 28.19019 ? 59  TYR A CE1 1 
ATOM   423  C CE2 . TYR A 1 59  ? 6.77306   -8.48392  52.33723  1.000 19.47924 ? 59  TYR A CE2 1 
ATOM   424  C CZ  . TYR A 1 59  ? 6.64882   -7.87406  51.10332  1.000 23.90618 ? 59  TYR A CZ  1 
ATOM   425  O OH  . TYR A 1 59  ? 5.40710   -7.55376  50.61276  1.000 27.99409 ? 59  TYR A OH  1 
ATOM   426  N N   . ASP A 1 60  ? 9.88226   -6.14754  54.18805  1.000 13.40277 ? 60  ASP A N   1 
ATOM   427  C CA  . ASP A 1 60  ? 8.80231   -5.66981  55.04436  1.000 17.77226 ? 60  ASP A CA  1 
ATOM   428  C C   . ASP A 1 60  ? 7.91546   -4.77155  54.20071  1.000 14.91750 ? 60  ASP A C   1 
ATOM   429  O O   . ASP A 1 60  ? 8.26500   -4.40772  53.07501  1.000 9.96448  ? 60  ASP A O   1 
ATOM   430  C CB  . ASP A 1 60  ? 9.33083   -4.95167  56.29387  1.000 8.32141  ? 60  ASP A CB  1 
ATOM   431  C CG  . ASP A 1 60  ? 9.45285   -5.88634  57.50689  1.000 14.00817 ? 60  ASP A CG  1 
ATOM   432  O OD1 . ASP A 1 60  ? 8.54256   -6.71780  57.74413  1.000 15.44398 ? 60  ASP A OD1 1 
ATOM   433  O OD2 . ASP A 1 60  ? 10.47322  -5.79937  58.21519  1.000 17.55251 ? 60  ASP A OD2 1 
ATOM   434  N N   . ARG A 1 61  ? 6.72804   -4.48129  54.72708  1.000 13.51043 ? 61  ARG A N   1 
ATOM   435  C CA  . ARG A 1 61  ? 5.79583   -3.59136  54.05981  1.000 17.05919 ? 61  ARG A CA  1 
ATOM   436  C C   . ARG A 1 61  ? 5.47472   -2.42273  54.97560  1.000 16.01780 ? 61  ARG A C   1 
ATOM   437  O O   . ARG A 1 61  ? 5.43946   -2.56597  56.20018  1.000 11.69781 ? 61  ARG A O   1 
ATOM   438  C CB  . ARG A 1 61  ? 4.48947   -4.29316  53.69018  1.000 15.87118 ? 61  ARG A CB  1 
ATOM   439  C CG  . ARG A 1 61  ? 4.65430   -5.71877  53.21426  1.000 27.59038 ? 61  ARG A CG  1 
ATOM   440  C CD  . ARG A 1 61  ? 3.29990   -6.30347  52.87911  1.000 18.19154 ? 61  ARG A CD  1 
ATOM   441  N NE  . ARG A 1 61  ? 2.72567   -5.66435  51.70317  1.000 17.56488 ? 61  ARG A NE  1 
ATOM   442  C CZ  . ARG A 1 61  ? 1.67282   -6.12531  51.04857  1.000 34.94979 ? 61  ARG A CZ  1 
ATOM   443  N NH1 . ARG A 1 61  ? 1.02161   -7.20036  51.46372  1.000 42.91257 ? 61  ARG A NH1 1 
ATOM   444  N NH2 . ARG A 1 61  ? 1.27256   -5.50101  49.94292  1.000 35.80325 ? 61  ARG A NH2 1 
ATOM   445  N N   . PHE A 1 62  ? 5.19142   -1.27868  54.36561  1.000 16.48556 ? 62  PHE A N   1 
ATOM   446  C CA  . PHE A 1 62  ? 4.92584   -0.05673  55.10644  1.000 12.84731 ? 62  PHE A CA  1 
ATOM   447  C C   . PHE A 1 62  ? 3.60430   0.54039   54.67392  1.000 15.95772 ? 62  PHE A C   1 
ATOM   448  O O   . PHE A 1 62  ? 3.27271   0.55055   53.48029  1.000 13.47405 ? 62  PHE A O   1 
ATOM   449  C CB  . PHE A 1 62  ? 6.02425   0.96312   54.89658  1.000 6.04205  ? 62  PHE A CB  1 
ATOM   450  C CG  . PHE A 1 62  ? 7.36041   0.49790   55.38775  1.000 12.26220 ? 62  PHE A CG  1 
ATOM   451  C CD1 . PHE A 1 62  ? 7.73440   0.72775   56.69051  1.000 8.56568  ? 62  PHE A CD1 1 
ATOM   452  C CD2 . PHE A 1 62  ? 8.24415   -0.17844  54.53180  1.000 14.40893 ? 62  PHE A CD2 1 
ATOM   453  C CE1 . PHE A 1 62  ? 8.98422   0.30305   57.16503  1.000 13.55632 ? 62  PHE A CE1 1 
ATOM   454  C CE2 . PHE A 1 62  ? 9.47814   -0.60518  54.98124  1.000 8.46151  ? 62  PHE A CE2 1 
ATOM   455  C CZ  . PHE A 1 62  ? 9.85252   -0.36026  56.31666  1.000 13.46044 ? 62  PHE A CZ  1 
ATOM   456  N N   . PHE A 1 63  ? 2.85604   1.01893   55.66763  1.000 15.62040 ? 63  PHE A N   1 
ATOM   457  C CA  . PHE A 1 63  ? 1.75399   1.95032   55.45470  1.000 15.47529 ? 63  PHE A CA  1 
ATOM   458  C C   . PHE A 1 63  ? 2.34709   3.34110   55.28795  1.000 12.28837 ? 63  PHE A C   1 
ATOM   459  O O   . PHE A 1 63  ? 3.16607   3.77297   56.10478  1.000 14.97320 ? 63  PHE A O   1 
ATOM   460  C CB  . PHE A 1 63  ? 0.80082   1.86786   56.66096  1.000 16.68218 ? 63  PHE A CB  1 
ATOM   461  C CG  . PHE A 1 63  ? -0.31211  2.88255   56.67365  1.000 18.01213 ? 63  PHE A CG  1 
ATOM   462  C CD1 . PHE A 1 63  ? -0.08740  4.17822   57.10947  1.000 19.60528 ? 63  PHE A CD1 1 
ATOM   463  C CD2 . PHE A 1 63  ? -1.60240  2.51680   56.31385  1.000 30.96880 ? 63  PHE A CD2 1 
ATOM   464  C CE1 . PHE A 1 63  ? -1.12846  5.10247   57.15946  1.000 32.22497 ? 63  PHE A CE1 1 
ATOM   465  C CE2 . PHE A 1 63  ? -2.65016  3.43162   56.35559  1.000 23.56158 ? 63  PHE A CE2 1 
ATOM   466  C CZ  . PHE A 1 63  ? -2.40784  4.73018   56.78032  1.000 28.56730 ? 63  PHE A CZ  1 
ATOM   467  N N   . PHE A 1 64  ? 1.95045   4.04157   54.23025  1.000 13.99442 ? 64  PHE A N   1 
ATOM   468  C CA  . PHE A 1 64  ? 2.58353   5.30189   53.86014  1.000 11.45157 ? 64  PHE A CA  1 
ATOM   469  C C   . PHE A 1 64  ? 1.53655   6.29336   53.37113  1.000 17.94128 ? 64  PHE A C   1 
ATOM   470  O O   . PHE A 1 64  ? 0.76708   5.97838   52.45787  1.000 21.53175 ? 64  PHE A O   1 
ATOM   471  C CB  . PHE A 1 64  ? 3.62575   5.06531   52.75766  1.000 11.53562 ? 64  PHE A CB  1 
ATOM   472  C CG  . PHE A 1 64  ? 4.19938   6.30729   52.17849  1.000 13.24163 ? 64  PHE A CG  1 
ATOM   473  C CD1 . PHE A 1 64  ? 4.66739   7.31505   52.99284  1.000 15.30521 ? 64  PHE A CD1 1 
ATOM   474  C CD2 . PHE A 1 64  ? 4.31290   6.45349   50.80617  1.000 9.58558  ? 64  PHE A CD2 1 
ATOM   475  C CE1 . PHE A 1 64  ? 5.23374   8.45789   52.45592  1.000 13.18582 ? 64  PHE A CE1 1 
ATOM   476  C CE2 . PHE A 1 64  ? 4.87677   7.59342   50.26262  1.000 13.78772 ? 64  PHE A CE2 1 
ATOM   477  C CZ  . PHE A 1 64  ? 5.34461   8.59927   51.09181  1.000 11.06277 ? 64  PHE A CZ  1 
ATOM   478  N N   . VAL A 1 65  ? 1.52698   7.48778   53.95810  1.000 18.16634 ? 65  VAL A N   1 
ATOM   479  C CA  . VAL A 1 65  ? 0.63821   8.56228   53.51959  1.000 20.19023 ? 65  VAL A CA  1 
ATOM   480  C C   . VAL A 1 65  ? 1.49962   9.71197   53.02925  1.000 17.25164 ? 65  VAL A C   1 
ATOM   481  O O   . VAL A 1 65  ? 2.16049   10.38293  53.83146  1.000 23.46245 ? 65  VAL A O   1 
ATOM   482  C CB  . VAL A 1 65  ? -0.30183  9.04660   54.63761  1.000 30.80807 ? 65  VAL A CB  1 
ATOM   483  C CG1 . VAL A 1 65  ? -1.17808  10.18697  54.10923  1.000 26.90367 ? 65  VAL A CG1 1 
ATOM   484  C CG2 . VAL A 1 65  ? -1.16008  7.91089   55.16356  1.000 19.86612 ? 65  VAL A CG2 1 
ATOM   485  N N   . PRO A 1 66  ? 1.52322   9.97526   51.73051  1.000 17.90971 ? 66  PRO A N   1 
ATOM   486  C CA  . PRO A 1 66  ? 2.46817   10.97152  51.21128  1.000 15.00988 ? 66  PRO A CA  1 
ATOM   487  C C   . PRO A 1 66  ? 2.23448   12.38031  51.73026  1.000 28.89833 ? 66  PRO A C   1 
ATOM   488  O O   . PRO A 1 66  ? 3.20732   13.12757  51.91684  1.000 21.22214 ? 66  PRO A O   1 
ATOM   489  C CB  . PRO A 1 66  ? 2.25777   10.87833  49.69354  1.000 20.55875 ? 66  PRO A CB  1 
ATOM   490  C CG  . PRO A 1 66  ? 1.69297   9.50159   49.48354  1.000 17.20737 ? 66  PRO A CG  1 
ATOM   491  C CD  . PRO A 1 66  ? 0.85700   9.20748   50.66729  1.000 17.00474 ? 66  PRO A CD  1 
ATOM   492  N N   . ARG A 1 67  ? 0.97608   12.77107  51.96536  1.000 29.56247 ? 67  ARG A N   1 
ATOM   493  C CA  . ARG A 1 67  ? 0.69990   14.13005  52.42956  1.000 34.02178 ? 67  ARG A CA  1 
ATOM   494  C C   . ARG A 1 67  ? 1.38475   14.39676  53.75934  1.000 33.33257 ? 67  ARG A C   1 
ATOM   495  O O   . ARG A 1 67  ? 2.08390   15.40308  53.91925  1.000 34.30201 ? 67  ARG A O   1 
ATOM   496  C CB  . ARG A 1 67  ? -0.81243  14.35526  52.55630  1.000 45.96420 ? 67  ARG A CB  1 
ATOM   497  C CG  . ARG A 1 67  ? -1.24038  15.83161  52.65583  1.000 45.99443 ? 67  ARG A CG  1 
ATOM   498  C CD  . ARG A 1 67  ? -1.38550  16.48536  51.27967  1.000 44.35898 ? 67  ARG A CD  1 
ATOM   499  N NE  . ARG A 1 67  ? -2.61153  16.08418  50.59105  1.000 41.83767 ? 67  ARG A NE  1 
ATOM   500  C CZ  . ARG A 1 67  ? -2.92567  16.44179  49.35029  1.000 43.25186 ? 67  ARG A CZ  1 
ATOM   501  N NH1 . ARG A 1 67  ? -2.14138  17.23474  48.63660  1.000 31.72568 ? 67  ARG A NH1 1 
ATOM   502  N NH2 . ARG A 1 67  ? -4.04984  15.98255  48.80639  1.000 42.91200 ? 67  ARG A NH2 1 
ATOM   503  N N   . THR A 1 68  ? 1.21313   13.48731  54.72253  1.000 26.11106 ? 68  THR A N   1 
ATOM   504  C CA  . THR A 1 68  ? 1.78746   13.66118  56.04777  1.000 28.63182 ? 68  THR A CA  1 
ATOM   505  C C   . THR A 1 68  ? 3.20641   13.13052  56.17469  1.000 36.68272 ? 68  THR A C   1 
ATOM   506  O O   . THR A 1 68  ? 3.90938   13.51633  57.11915  1.000 29.25246 ? 68  THR A O   1 
ATOM   507  C CB  . THR A 1 68  ? 0.89978   12.97788  57.09229  1.000 40.00997 ? 68  THR A CB  1 
ATOM   508  O OG1 . THR A 1 68  ? 0.71144   11.59997  56.74316  1.000 36.33271 ? 68  THR A OG1 1 
ATOM   509  C CG2 . THR A 1 68  ? -0.44793  13.65043  57.12983  1.000 32.09709 ? 68  THR A CG2 1 
ATOM   510  N N   . GLY A 1 69  ? 3.65487   12.28204  55.24210  1.000 32.41880 ? 69  GLY A N   1 
ATOM   511  C CA  . GLY A 1 69  ? 4.90455   11.57787  55.43551  1.000 22.17811 ? 69  GLY A CA  1 
ATOM   512  C C   . GLY A 1 69  ? 4.82837   10.47318  56.46293  1.000 26.50007 ? 69  GLY A C   1 
ATOM   513  O O   . GLY A 1 69  ? 5.87606   9.96413   56.88169  1.000 23.78133 ? 69  GLY A O   1 
ATOM   514  N N   . GLU A 1 70  ? 3.61891   10.11352  56.90384  1.000 24.61518 ? 70  GLU A N   1 
ATOM   515  C CA  . GLU A 1 70  ? 3.44692   9.02830   57.86004  1.000 25.83654 ? 70  GLU A CA  1 
ATOM   516  C C   . GLU A 1 70  ? 3.90946   7.70864   57.26295  1.000 23.58391 ? 70  GLU A C   1 
ATOM   517  O O   . GLU A 1 70  ? 3.44456   7.29635   56.19570  1.000 16.58931 ? 70  GLU A O   1 
ATOM   518  C CB  . GLU A 1 70  ? 1.99118   8.89656   58.28033  1.000 21.04539 ? 70  GLU A CB  1 
ATOM   519  C CG  . GLU A 1 70  ? 1.80197   7.80104   59.30726  1.000 19.65969 ? 70  GLU A CG  1 
ATOM   520  C CD  . GLU A 1 70  ? 0.38048   7.65968   59.76912  1.000 20.46548 ? 70  GLU A CD  1 
ATOM   521  O OE1 . GLU A 1 70  ? -0.51545  8.26464   59.14118  1.000 21.50827 ? 70  GLU A OE1 1 
ATOM   522  O OE2 . GLU A 1 70  ? 0.16108   6.94940   60.77490  1.000 22.47624 ? 70  GLU A OE2 1 
ATOM   523  N N   . VAL A 1 71  ? 4.81490   7.03976   57.96945  1.000 21.56461 ? 71  VAL A N   1 
ATOM   524  C CA  . VAL A 1 71  ? 5.28479   5.70957   57.60589  1.000 16.93741 ? 71  VAL A CA  1 
ATOM   525  C C   . VAL A 1 71  ? 5.08693   4.80287   58.80630  1.000 17.13889 ? 71  VAL A C   1 
ATOM   526  O O   . VAL A 1 71  ? 5.62948   5.06940   59.88342  1.000 15.41444 ? 71  VAL A O   1 
ATOM   527  C CB  . VAL A 1 71  ? 6.76326   5.71480   57.19350  1.000 17.66335 ? 71  VAL A CB  1 
ATOM   528  C CG1 . VAL A 1 71  ? 7.17542   4.30424   56.73975  1.000 14.56656 ? 71  VAL A CG1 1 
ATOM   529  C CG2 . VAL A 1 71  ? 7.02652   6.76084   56.10661  1.000 17.15300 ? 71  VAL A CG2 1 
ATOM   530  N N   . ARG A 1 72  ? 4.33170   3.73299   58.62331  1.000 14.76295 ? 72  ARG A N   1 
ATOM   531  C CA  . ARG A 1 72  ? 4.13610   2.73375   59.65145  1.000 15.69918 ? 72  ARG A CA  1 
ATOM   532  C C   . ARG A 1 72  ? 4.59745   1.38586   59.11714  1.000 14.51946 ? 72  ARG A C   1 
ATOM   533  O O   . ARG A 1 72  ? 4.30052   1.03216   57.97565  1.000 15.72527 ? 72  ARG A O   1 
ATOM   534  C CB  . ARG A 1 72  ? 2.66239   2.65902   60.07504  1.000 18.22561 ? 72  ARG A CB  1 
ATOM   535  C CG  . ARG A 1 72  ? 2.02189   4.00601   60.40752  1.000 19.44542 ? 72  ARG A CG  1 
ATOM   536  C CD  . ARG A 1 72  ? 0.51585   3.84998   60.56638  1.000 21.33523 ? 72  ARG A CD  1 
ATOM   537  N NE  . ARG A 1 72  ? 0.21517   2.81976   61.55271  1.000 22.01627 ? 72  ARG A NE  1 
ATOM   538  C CZ  . ARG A 1 72  ? 0.25080   3.00957   62.86466  1.000 29.22325 ? 72  ARG A CZ  1 
ATOM   539  N NH1 . ARG A 1 72  ? 0.54519   4.19119   63.38695  1.000 27.60791 ? 72  ARG A NH1 1 
ATOM   540  N NH2 . ARG A 1 72  ? -0.01760  1.98935   63.67419  1.000 31.99658 ? 72  ARG A NH2 1 
ATOM   541  N N   . LEU A 1 73  ? 5.33158   0.64643   59.94319  1.000 12.92767 ? 73  LEU A N   1 
ATOM   542  C CA  . LEU A 1 73  ? 5.75088   -0.71005  59.61643  1.000 9.33622  ? 73  LEU A CA  1 
ATOM   543  C C   . LEU A 1 73  ? 4.56191   -1.64103  59.79283  1.000 25.12550 ? 73  LEU A C   1 
ATOM   544  O O   . LEU A 1 73  ? 4.04389   -1.78818  60.90837  1.000 26.40878 ? 73  LEU A O   1 
ATOM   545  C CB  . LEU A 1 73  ? 6.91586   -1.14317  60.51341  1.000 16.58552 ? 73  LEU A CB  1 
ATOM   546  C CG  . LEU A 1 73  ? 7.46442   -2.57035  60.35518  1.000 21.40194 ? 73  LEU A CG  1 
ATOM   547  C CD1 . LEU A 1 73  ? 7.94908   -2.79353  58.92970  1.000 15.74444 ? 73  LEU A CD1 1 
ATOM   548  C CD2 . LEU A 1 73  ? 8.58749   -2.86753  61.36289  1.000 14.17692 ? 73  LEU A CD2 1 
ATOM   549  N N   . ARG A 1 74  ? 4.10750   -2.24199  58.69991  1.000 10.79071 ? 74  ARG A N   1 
ATOM   550  C CA  . ARG A 1 74  ? 3.01330   -3.18132  58.80939  1.000 18.49271 ? 74  ARG A CA  1 
ATOM   551  C C   . ARG A 1 74  ? 3.48684   -4.49669  59.42151  1.000 19.41263 ? 74  ARG A C   1 
ATOM   552  O O   . ARG A 1 74  ? 4.64294   -4.89745  59.24865  1.000 16.83944 ? 74  ARG A O   1 
ATOM   553  C CB  . ARG A 1 74  ? 2.38742   -3.42796  57.43122  1.000 14.07487 ? 74  ARG A CB  1 
ATOM   554  C CG  . ARG A 1 74  ? 1.85557   -2.15599  56.78897  1.000 17.64298 ? 74  ARG A CG  1 
ATOM   555  C CD  . ARG A 1 74  ? 1.18710   -2.44149  55.45685  1.000 22.23408 ? 74  ARG A CD  1 
ATOM   556  N NE  . ARG A 1 74  ? 0.18827   -3.49888  55.58260  1.000 31.99934 ? 74  ARG A NE  1 
ATOM   557  C CZ  . ARG A 1 74  ? -0.43793  -4.05654  54.55235  1.000 37.04423 ? 74  ARG A CZ  1 
ATOM   558  N NH1 . ARG A 1 74  ? -0.20471  -3.66709  53.30737  1.000 25.57949 ? 74  ARG A NH1 1 
ATOM   559  N NH2 . ARG A 1 74  ? -1.31775  -5.03163  54.77724  1.000 42.85428 ? 74  ARG A NH2 1 
ATOM   560  N N   . PRO A 1 75  ? 2.61612   -5.16837  60.17515  1.000 25.57006 ? 75  PRO A N   1 
ATOM   561  C CA  . PRO A 1 75  ? 2.99844   -6.44808  60.78042  1.000 20.78394 ? 75  PRO A CA  1 
ATOM   562  C C   . PRO A 1 75  ? 3.45317   -7.43175  59.71499  1.000 16.81494 ? 75  PRO A C   1 
ATOM   563  O O   . PRO A 1 75  ? 2.92975   -7.45634  58.60119  1.000 19.88926 ? 75  PRO A O   1 
ATOM   564  C CB  . PRO A 1 75  ? 1.70982   -6.91739  61.47291  1.000 30.61810 ? 75  PRO A CB  1 
ATOM   565  C CG  . PRO A 1 75  ? 0.92415   -5.67727  61.69862  1.000 30.96561 ? 75  PRO A CG  1 
ATOM   566  C CD  . PRO A 1 75  ? 1.24601   -4.76927  60.53625  1.000 29.10182 ? 75  PRO A CD  1 
ATOM   567  N N   . HIS A 1 76  ? 4.45374   -8.22984  60.06000  1.000 17.83339 ? 76  HIS A N   1 
ATOM   568  C CA  . HIS A 1 76  ? 5.10194   -9.11864  59.09880  1.000 18.96033 ? 76  HIS A CA  1 
ATOM   569  C C   . HIS A 1 76  ? 4.19461   -10.33431 58.90587  1.000 24.32949 ? 76  HIS A C   1 
ATOM   570  O O   . HIS A 1 76  ? 4.19799   -11.27313 59.70720  1.000 23.24826 ? 76  HIS A O   1 
ATOM   571  C CB  . HIS A 1 76  ? 6.49772   -9.49322  59.60142  1.000 22.03062 ? 76  HIS A CB  1 
ATOM   572  C CG  . HIS A 1 76  ? 7.36992   -10.14710 58.57149  1.000 28.42462 ? 76  HIS A CG  1 
ATOM   573  N ND1 . HIS A 1 76  ? 7.96646   -9.44900  57.54214  1.000 29.48229 ? 76  HIS A ND1 1 
ATOM   574  C CD2 . HIS A 1 76  ? 7.76271   -11.43544 58.42666  1.000 29.47295 ? 76  HIS A CD2 1 
ATOM   575  C CE1 . HIS A 1 76  ? 8.66953   -10.28284 56.79485  1.000 21.01750 ? 76  HIS A CE1 1 
ATOM   576  N NE2 . HIS A 1 76  ? 8.56112   -11.49390 57.30833  1.000 25.61202 ? 76  HIS A NE2 1 
ATOM   577  N N   . ARG A 1 77  ? 3.39774   -10.31600 57.85064  1.000 19.53653 ? 77  ARG A N   1 
ATOM   578  C CA  . ARG A 1 77  ? 2.37993   -11.33935 57.67183  1.000 23.75971 ? 77  ARG A CA  1 
ATOM   579  C C   . ARG A 1 77  ? 3.02585   -12.71385 57.53748  1.000 29.56948 ? 77  ARG A C   1 
ATOM   580  O O   . ARG A 1 77  ? 3.81802   -12.92754 56.60304  1.000 21.32189 ? 77  ARG A O   1 
ATOM   581  C CB  . ARG A 1 77  ? 1.54064   -11.02140 56.44313  1.000 31.57122 ? 77  ARG A CB  1 
ATOM   582  C CG  . ARG A 1 77  ? 0.32840   -11.89878 56.29708  1.000 27.49771 ? 77  ARG A CG  1 
ATOM   583  C CD  . ARG A 1 77  ? -0.41427  -11.54560 55.03332  1.000 38.82393 ? 77  ARG A CD  1 
ATOM   584  N NE  . ARG A 1 77  ? -1.38538  -12.57611 54.68858  1.000 50.97182 ? 77  ARG A NE  1 
ATOM   585  C CZ  . ARG A 1 77  ? -2.64543  -12.57529 55.10049  1.000 49.68843 ? 77  ARG A CZ  1 
ATOM   586  N NH1 . ARG A 1 77  ? -3.12141  -11.59946 55.85757  1.000 40.82246 ? 77  ARG A NH1 1 
ATOM   587  N NH2 . ARG A 1 77  ? -3.44658  -13.57951 54.74717  1.000 39.45836 ? 77  ARG A NH2 1 
ATOM   588  N N   . PRO A 1 78  ? 2.73709   -13.66142 58.43584  1.000 23.12331 ? 78  PRO A N   1 
ATOM   589  C CA  . PRO A 1 78  ? 3.44239   -14.94770 58.39300  1.000 20.51385 ? 78  PRO A CA  1 
ATOM   590  C C   . PRO A 1 78  ? 3.10190   -15.72110 57.13761  1.000 18.16916 ? 78  PRO A C   1 
ATOM   591  O O   . PRO A 1 78  ? 1.96842   -15.69000 56.64842  1.000 20.33143 ? 78  PRO A O   1 
ATOM   592  C CB  . PRO A 1 78  ? 2.94672   -15.68383 59.64239  1.000 18.34072 ? 78  PRO A CB  1 
ATOM   593  C CG  . PRO A 1 78  ? 2.29478   -14.64217 60.49542  1.000 20.88187 ? 78  PRO A CG  1 
ATOM   594  C CD  . PRO A 1 78  ? 1.79663   -13.57928 59.56328  1.000 19.79888 ? 78  PRO A CD  1 
ATOM   595  N N   . TYR A 1 79  ? 4.10360   -16.43683 56.63554  1.000 22.68778 ? 79  TYR A N   1 
ATOM   596  C CA  . TYR A 1 79  ? 3.94252   -17.20465 55.40773  1.000 22.79625 ? 79  TYR A CA  1 
ATOM   597  C C   . TYR A 1 79  ? 2.89239   -18.30168 55.58353  1.000 27.94620 ? 79  TYR A C   1 
ATOM   598  O O   . TYR A 1 79  ? 2.01753   -18.49254 54.72521  1.000 25.18519 ? 79  TYR A O   1 
ATOM   599  C CB  . TYR A 1 79  ? 5.30743   -17.77382 55.00004  1.000 26.48579 ? 79  TYR A CB  1 
ATOM   600  C CG  . TYR A 1 79  ? 5.28883   -18.66974 53.77986  1.000 38.98154 ? 79  TYR A CG  1 
ATOM   601  C CD1 . TYR A 1 79  ? 4.89808   -18.18209 52.53723  1.000 49.99557 ? 79  TYR A CD1 1 
ATOM   602  C CD2 . TYR A 1 79  ? 5.68203   -19.99682 53.86823  1.000 36.87627 ? 79  TYR A CD2 1 
ATOM   603  C CE1 . TYR A 1 79  ? 4.88226   -19.00324 51.41473  1.000 50.58169 ? 79  TYR A CE1 1 
ATOM   604  C CE2 . TYR A 1 79  ? 5.67674   -20.82230 52.75930  1.000 45.24270 ? 79  TYR A CE2 1 
ATOM   605  C CZ  . TYR A 1 79  ? 5.27279   -20.32303 51.53614  1.000 57.68532 ? 79  TYR A CZ  1 
ATOM   606  O OH  . TYR A 1 79  ? 5.26646   -21.14877 50.43296  1.000 70.22828 ? 79  TYR A OH  1 
ATOM   607  N N   . PHE A 1 80  ? 2.93553   -19.00499 56.72154  1.000 26.82294 ? 80  PHE A N   1 
ATOM   608  C CA  . PHE A 1 80  ? 1.96719   -20.06064 56.99263  1.000 27.84609 ? 80  PHE A CA  1 
ATOM   609  C C   . PHE A 1 80  ? 0.54235   -19.54398 56.99675  1.000 24.36777 ? 80  PHE A C   1 
ATOM   610  O O   . PHE A 1 80  ? -0.38920  -20.32686 56.81495  1.000 31.53039 ? 80  PHE A O   1 
ATOM   611  C CB  . PHE A 1 80  ? 2.27526   -20.74871 58.33908  1.000 29.39113 ? 80  PHE A CB  1 
ATOM   612  C CG  . PHE A 1 80  ? 1.98172   -19.90084 59.55553  1.000 23.16807 ? 80  PHE A CG  1 
ATOM   613  C CD1 . PHE A 1 80  ? 0.67790   -19.70739 59.99674  1.000 24.84477 ? 80  PHE A CD1 1 
ATOM   614  C CD2 . PHE A 1 80  ? 3.00944   -19.33067 60.28116  1.000 20.51758 ? 80  PHE A CD2 1 
ATOM   615  C CE1 . PHE A 1 80  ? 0.41238   -18.93818 61.09298  1.000 16.33139 ? 80  PHE A CE1 1 
ATOM   616  C CE2 . PHE A 1 80  ? 2.73829   -18.57209 61.39199  1.000 19.60328 ? 80  PHE A CE2 1 
ATOM   617  C CZ  . PHE A 1 80  ? 1.42833   -18.37238 61.78808  1.000 19.19552 ? 80  PHE A CZ  1 
ATOM   618  N N   . GLN A 1 81  ? 0.34630   -18.25428 57.23836  1.000 22.88380 ? 81  GLN A N   1 
ATOM   619  C CA  . GLN A 1 81  ? -1.00042  -17.70916 57.24414  1.000 24.34013 ? 81  GLN A CA  1 
ATOM   620  C C   . GLN A 1 81  ? -1.46704  -17.41718 55.83094  1.000 43.81309 ? 81  GLN A C   1 
ATOM   621  O O   . GLN A 1 81  ? -2.60683  -17.73933 55.46863  1.000 32.42597 ? 81  GLN A O   1 
ATOM   622  C CB  . GLN A 1 81  ? -1.04290  -16.43758 58.08884  1.000 27.98504 ? 81  GLN A CB  1 
ATOM   623  C CG  . GLN A 1 81  ? -2.42230  -15.96702 58.43303  1.000 24.19602 ? 81  GLN A CG  1 
ATOM   624  C CD  . GLN A 1 81  ? -2.41091  -14.57228 58.97016  1.000 26.97248 ? 81  GLN A CD  1 
ATOM   625  O OE1 . GLN A 1 81  ? -1.93575  -14.32164 60.07663  1.000 32.66909 ? 81  GLN A OE1 1 
ATOM   626  N NE2 . GLN A 1 81  ? -2.91109  -13.63939 58.18159  1.000 35.78205 ? 81  GLN A NE2 1 
ATOM   627  N N   . SER A 1 82  ? -0.58332  -16.80804 55.03367  1.000 35.91656 ? 82  SER A N   1 
ATOM   628  C CA  . SER A 1 82  ? -0.86293  -16.54677 53.62612  1.000 41.41978 ? 82  SER A CA  1 
ATOM   629  C C   . SER A 1 82  ? -1.16105  -17.83739 52.87469  1.000 39.66564 ? 82  SER A C   1 
ATOM   630  O O   . SER A 1 82  ? -2.21274  -17.97855 52.24063  1.000 42.77361 ? 82  SER A O   1 
ATOM   631  C CB  . SER A 1 82  ? 0.33012   -15.82613 52.99125  1.000 39.34600 ? 82  SER A CB  1 
ATOM   632  O OG  . SER A 1 82  ? 0.44610   -14.49591 53.45490  1.000 35.16620 ? 82  SER A OG  1 
ATOM   633  N N   . MET A 1 83  ? -0.22528  -18.78559 52.92152  1.000 39.29336 ? 83  MET A N   1 
ATOM   634  C CA  . MET A 1 83  ? -0.38725  -20.04828 52.21280  1.000 43.52665 ? 83  MET A CA  1 
ATOM   635  C C   . MET A 1 83  ? -1.70129  -20.72803 52.58525  1.000 47.75704 ? 83  MET A C   1 
ATOM   636  O O   . MET A 1 83  ? -2.54809  -20.99454 51.72387  1.000 51.38013 ? 83  MET A O   1 
ATOM   637  C CB  . MET A 1 83  ? 0.80102   -20.95938 52.51780  1.000 36.23618 ? 83  MET A CB  1 
ATOM   638  C CG  . MET A 1 83  ? 0.57393   -22.40353 52.14402  1.000 55.19891 ? 83  MET A CG  1 
ATOM   639  S SD  . MET A 1 83  ? 1.35711   -23.53144 53.31208  1.000 82.46417 ? 83  MET A SD  1 
ATOM   640  C CE  . MET A 1 83  ? 3.05086   -22.93713 53.30230  1.000 47.31534 ? 83  MET A CE  1 
ATOM   641  N N   . ASN A 1 84  ? -1.89219  -20.99897 53.87921  1.000 37.40163 ? 84  ASN A N   1 
ATOM   642  C CA  . ASN A 1 84  ? -3.07314  -21.72277 54.33535  1.000 33.87897 ? 84  ASN A CA  1 
ATOM   643  C C   . ASN A 1 84  ? -4.36529  -20.95312 54.08065  1.000 38.71906 ? 84  ASN A C   1 
ATOM   644  O O   . ASN A 1 84  ? -5.43090  -21.57288 53.97253  1.000 35.60793 ? 84  ASN A O   1 
ATOM   645  C CB  . ASN A 1 84  ? -2.92274  -22.07051 55.82021  1.000 30.93423 ? 84  ASN A CB  1 
ATOM   646  C CG  . ASN A 1 84  ? -1.91673  -23.19935 56.05501  1.000 40.52855 ? 84  ASN A CG  1 
ATOM   647  O OD1 . ASN A 1 84  ? -2.25028  -24.37988 55.92325  1.000 35.96414 ? 84  ASN A OD1 1 
ATOM   648  N ND2 . ASN A 1 84  ? -0.68190  -22.83882 56.39256  1.000 27.55496 ? 84  ASN A ND2 1 
ATOM   649  N N   . ALA A 1 85  ? -4.29979  -19.62842 53.96181  1.000 33.93643 ? 85  ALA A N   1 
ATOM   650  C CA  . ALA A 1 85  ? -5.45595  -18.83994 53.55426  1.000 37.87373 ? 85  ALA A CA  1 
ATOM   651  C C   . ALA A 1 85  ? -5.57570  -18.70927 52.04303  1.000 45.00730 ? 85  ALA A C   1 
ATOM   652  O O   . ALA A 1 85  ? -6.55894  -18.12830 51.57032  1.000 57.86252 ? 85  ALA A O   1 
ATOM   653  C CB  . ALA A 1 85  ? -5.40694  -17.43746 54.17733  1.000 32.67949 ? 85  ALA A CB  1 
ATOM   654  N N   . ASN A 1 86  ? -4.62207  -19.26651 51.28604  1.000 41.53507 ? 86  ASN A N   1 
ATOM   655  C CA  . ASN A 1 86  ? -4.41681  -18.96493 49.87050  1.000 51.88929 ? 86  ASN A CA  1 
ATOM   656  C C   . ASN A 1 86  ? -4.72839  -17.50169 49.59431  1.000 51.92061 ? 86  ASN A C   1 
ATOM   657  O O   . ASN A 1 86  ? -5.60101  -17.17609 48.78134  1.000 42.83472 ? 86  ASN A O   1 
ATOM   658  C CB  . ASN A 1 86  ? -5.24777  -19.87491 48.96261  1.000 59.03722 ? 86  ASN A CB  1 
ATOM   659  C CG  . ASN A 1 86  ? -4.73954  -19.86964 47.52051  1.000 63.64324 ? 86  ASN A CG  1 
ATOM   660  O OD1 . ASN A 1 86  ? -3.59009  -20.23202 47.25458  1.000 63.50256 ? 86  ASN A OD1 1 
ATOM   661  N ND2 . ASN A 1 86  ? -5.59034  -19.45353 46.58967  1.000 58.96764 ? 86  ASN A ND2 1 
ATOM   662  N N   . ASP A 1 87  ? -4.01970  -16.62119 50.29972  1.000 54.70170 ? 87  ASP A N   1 
ATOM   663  C CA  . ASP A 1 87  ? -4.22316  -15.18114 50.18932  1.000 48.10683 ? 87  ASP A CA  1 
ATOM   664  C C   . ASP A 1 87  ? -2.94437  -14.53703 50.69886  1.000 55.01085 ? 87  ASP A C   1 
ATOM   665  O O   . ASP A 1 87  ? -2.69186  -14.51898 51.91424  1.000 46.23301 ? 87  ASP A O   1 
ATOM   666  C CB  . ASP A 1 87  ? -5.44563  -14.73936 50.98196  1.000 47.07686 ? 87  ASP A CB  1 
ATOM   667  C CG  . ASP A 1 87  ? -5.73950  -13.24760 50.83985  1.000 62.96077 ? 87  ASP A CG  1 
ATOM   668  O OD1 . ASP A 1 87  ? -4.89757  -12.49803 50.28631  1.000 57.20397 ? 87  ASP A OD1 1 
ATOM   669  O OD2 . ASP A 1 87  ? -6.82769  -12.82149 51.28809  1.000 68.59865 ? 87  ASP A OD2 1 
ATOM   670  N N   . TYR A 1 88  ? -2.13172  -14.02113 49.77844  1.000 52.67819 ? 88  TYR A N   1 
ATOM   671  C CA  . TYR A 1 88  ? -0.88466  -13.36272 50.12179  1.000 49.89443 ? 88  TYR A CA  1 
ATOM   672  C C   . TYR A 1 88  ? -1.05268  -11.86458 50.32896  1.000 45.29265 ? 88  TYR A C   1 
ATOM   673  O O   . TYR A 1 88  ? -0.05026  -11.15624 50.46526  1.000 41.63880 ? 88  TYR A O   1 
ATOM   674  C CB  . TYR A 1 88  ? 0.17272   -13.66455 49.05386  1.000 56.04344 ? 88  TYR A CB  1 
ATOM   675  C CG  . TYR A 1 88  ? 0.58460   -15.12211 49.07979  1.000 56.78655 ? 88  TYR A CG  1 
ATOM   676  C CD1 . TYR A 1 88  ? -0.09022  -16.07367 48.31715  1.000 51.95398 ? 88  TYR A CD1 1 
ATOM   677  C CD2 . TYR A 1 88  ? 1.61557   -15.55494 49.90508  1.000 49.11260 ? 88  TYR A CD2 1 
ATOM   678  C CE1 . TYR A 1 88  ? 0.27022   -17.41129 48.35964  1.000 53.50046 ? 88  TYR A CE1 1 
ATOM   679  C CE2 . TYR A 1 88  ? 1.98317   -16.89001 49.95599  1.000 52.83696 ? 88  TYR A CE2 1 
ATOM   680  C CZ  . TYR A 1 88  ? 1.30772   -17.81389 49.18025  1.000 57.29312 ? 88  TYR A CZ  1 
ATOM   681  O OH  . TYR A 1 88  ? 1.66818   -19.14409 49.22668  1.000 64.54539 ? 88  TYR A OH  1 
ATOM   682  N N   . ALA A 1 89  ? -2.29966  -11.37879 50.34939  1.000 51.96569 ? 89  ALA A N   1 
ATOM   683  C CA  . ALA A 1 89  ? -2.63975  -10.02642 50.80854  1.000 58.74215 ? 89  ALA A CA  1 
ATOM   684  C C   . ALA A 1 89  ? -1.92759  -8.94856  49.99358  1.000 61.18806 ? 89  ALA A C   1 
ATOM   685  O O   . ALA A 1 89  ? -1.56085  -7.88981  50.51457  1.000 44.55387 ? 89  ALA A O   1 
ATOM   686  C CB  . ALA A 1 89  ? -2.34528  -9.86361  52.30199  1.000 55.18014 ? 89  ALA A CB  1 
ATOM   687  N N   . GLY A 1 90  ? -1.74007  -9.21869  48.69798  1.000 57.27396 ? 90  GLY A N   1 
ATOM   688  C CA  . GLY A 1 90  ? -1.02642  -8.32286  47.81804  1.000 40.11198 ? 90  GLY A CA  1 
ATOM   689  C C   . GLY A 1 90  ? 0.48152   -8.41847  47.89222  1.000 47.08896 ? 90  GLY A C   1 
ATOM   690  O O   . GLY A 1 90  ? 1.15803   -7.98969  46.95026  1.000 55.15734 ? 90  GLY A O   1 
ATOM   691  N N   . GLY A 1 91  ? 1.03124   -8.96448  48.97770  1.000 50.14447 ? 91  GLY A N   1 
ATOM   692  C CA  . GLY A 1 91  ? 2.46414   -9.09959  49.14158  1.000 48.77995 ? 91  GLY A CA  1 
ATOM   693  C C   . GLY A 1 91  ? 3.02858   -10.26132 48.34303  1.000 48.22929 ? 91  GLY A C   1 
ATOM   694  O O   . GLY A 1 91  ? 2.33485   -10.92948 47.57324  1.000 54.64927 ? 91  GLY A O   1 
ATOM   695  N N   . ILE A 1 92  ? 4.32942   -10.50282 48.53535  1.000 50.24101 ? 92  ILE A N   1 
ATOM   696  C CA  . ILE A 1 92  ? 4.98715   -11.57674 47.79640  1.000 52.53691 ? 92  ILE A CA  1 
ATOM   697  C C   . ILE A 1 92  ? 4.47905   -12.92866 48.28142  1.000 50.74612 ? 92  ILE A C   1 
ATOM   698  O O   . ILE A 1 92  ? 4.01729   -13.07946 49.41933  1.000 43.67706 ? 92  ILE A O   1 
ATOM   699  C CB  . ILE A 1 92  ? 6.52069   -11.48891 47.91180  1.000 49.47714 ? 92  ILE A CB  1 
ATOM   700  C CG1 . ILE A 1 92  ? 6.96596   -11.57131 49.37530  1.000 48.79959 ? 92  ILE A CG1 1 
ATOM   701  C CG2 . ILE A 1 92  ? 7.02795   -10.21565 47.23701  1.000 45.23013 ? 92  ILE A CG2 1 
ATOM   702  C CD1 . ILE A 1 92  ? 8.43456   -11.23452 49.58918  1.000 43.31939 ? 92  ILE A CD1 1 
ATOM   703  N N   . ASP A 1 93  ? 4.53836   -13.91955 47.39457  1.000 59.45381 ? 93  ASP A N   1 
ATOM   704  C CA  . ASP A 1 93  ? 4.19731   -15.29948 47.73063  1.000 57.63740 ? 93  ASP A CA  1 
ATOM   705  C C   . ASP A 1 93  ? 5.43609   -16.11447 48.08631  1.000 63.54601 ? 93  ASP A C   1 
ATOM   706  O O   . ASP A 1 93  ? 5.57600   -17.27336 47.68284  1.000 61.33200 ? 93  ASP A O   1 
ATOM   707  C CB  . ASP A 1 93  ? 3.41674   -15.95288 46.59154  1.000 60.81518 ? 93  ASP A CB  1 
ATOM   708  C CG  . ASP A 1 93  ? 3.96179   -15.59493 45.22179  1.000 62.70333 ? 93  ASP A CG  1 
ATOM   709  O OD1 . ASP A 1 93  ? 4.09840   -14.38619 44.92599  1.000 64.72067 ? 93  ASP A OD1 1 
ATOM   710  O OD2 . ASP A 1 93  ? 4.25499   -16.52615 44.44130  1.000 58.60873 ? 93  ASP A OD2 1 
ATOM   711  N N   . ARG A 1 94  ? 6.35492   -15.51942 48.84533  1.000 57.56547 ? 94  ARG A N   1 
ATOM   712  C CA  . ARG A 1 94  ? 7.54977   -16.19602 49.32133  1.000 52.45387 ? 94  ARG A CA  1 
ATOM   713  C C   . ARG A 1 94  ? 7.71230   -15.95273 50.81469  1.000 51.76543 ? 94  ARG A C   1 
ATOM   714  O O   . ARG A 1 94  ? 7.07743   -15.07199 51.40436  1.000 49.93214 ? 94  ARG A O   1 
ATOM   715  C CB  . ARG A 1 94  ? 8.80110   -15.73423 48.56515  1.000 51.65588 ? 94  ARG A CB  1 
ATOM   716  C CG  . ARG A 1 94  ? 9.00128   -16.46564 47.26172  1.000 61.06495 ? 94  ARG A CG  1 
ATOM   717  C CD  . ARG A 1 94  ? 8.98897   -17.96074 47.49625  1.000 58.07770 ? 94  ARG A CD  1 
ATOM   718  N NE  . ARG A 1 94  ? 8.92092   -18.71556 46.25041  1.000 63.84350 ? 94  ARG A NE  1 
ATOM   719  C CZ  . ARG A 1 94  ? 9.97178   -19.01092 45.49722  1.000 63.08569 ? 94  ARG A CZ  1 
ATOM   720  N NH1 . ARG A 1 94  ? 11.18916  -18.60101 45.81743  1.000 71.70983 ? 94  ARG A NH1 1 
ATOM   721  N NH2 . ARG A 1 94  ? 9.79787   -19.73543 44.39544  1.000 56.63616 ? 94  ARG A NH2 1 
ATOM   722  N N   . ASP A 1 95  ? 8.58304   -16.75129 51.42128  1.000 43.19983 ? 95  ASP A N   1 
ATOM   723  C CA  . ASP A 1 95  ? 8.82509   -16.72817 52.85913  1.000 44.54407 ? 95  ASP A CA  1 
ATOM   724  C C   . ASP A 1 95  ? 10.16984  -16.05338 53.10595  1.000 44.91203 ? 95  ASP A C   1 
ATOM   725  O O   . ASP A 1 95  ? 11.22136  -16.62580 52.80833  1.000 48.69568 ? 95  ASP A O   1 
ATOM   726  C CB  . ASP A 1 95  ? 8.78704   -18.14754 53.41871  1.000 34.83160 ? 95  ASP A CB  1 
ATOM   727  C CG  . ASP A 1 95  ? 9.46511   -18.26325 54.75875  1.000 40.77417 ? 95  ASP A CG  1 
ATOM   728  O OD1 . ASP A 1 95  ? 9.07413   -17.53421 55.69256  1.000 54.35279 ? 95  ASP A OD1 1 
ATOM   729  O OD2 . ASP A 1 95  ? 10.38639  -19.09465 54.87936  1.000 48.69682 ? 95  ASP A OD2 1 
ATOM   730  N N   . VAL A 1 96  ? 10.13464  -14.83235 53.63410  1.000 31.92331 ? 96  VAL A N   1 
ATOM   731  C CA  . VAL A 1 96  ? 11.31418  -13.98499 53.74690  1.000 28.41623 ? 96  VAL A CA  1 
ATOM   732  C C   . VAL A 1 96  ? 11.40096  -13.42605 55.16240  1.000 21.89473 ? 96  VAL A C   1 
ATOM   733  O O   . VAL A 1 96  ? 10.37637  -13.10905 55.77588  1.000 28.54324 ? 96  VAL A O   1 
ATOM   734  C CB  . VAL A 1 96  ? 11.26674  -12.84158 52.71102  1.000 34.53567 ? 96  VAL A CB  1 
ATOM   735  C CG1 . VAL A 1 96  ? 12.49466  -11.98061 52.82099  1.000 29.11741 ? 96  VAL A CG1 1 
ATOM   736  C CG2 . VAL A 1 96  ? 11.13551  -13.38616 51.30083  1.000 29.77298 ? 96  VAL A CG2 1 
ATOM   737  N N   . ALA A 1 97  ? 12.62232  -13.29651 55.67864  1.000 14.32032 ? 97  ALA A N   1 
ATOM   738  C CA  . ALA A 1 97  ? 12.82212  -12.70039 56.98888  1.000 16.20717 ? 97  ALA A CA  1 
ATOM   739  C C   . ALA A 1 97  ? 12.51797  -11.19567 56.97149  1.000 24.79871 ? 97  ALA A C   1 
ATOM   740  O O   . ALA A 1 97  ? 12.56718  -10.54794 55.91769  1.000 16.79493 ? 97  ALA A O   1 
ATOM   741  C CB  . ALA A 1 97  ? 14.25419  -12.94322 57.45944  1.000 20.73374 ? 97  ALA A CB  1 
ATOM   742  N N   . PRO A 1 98  ? 12.17177  -10.62233 58.12696  1.000 19.07835 ? 98  PRO A N   1 
ATOM   743  C CA  . PRO A 1 98  ? 11.97552  -9.17087  58.19629  1.000 15.52099 ? 98  PRO A CA  1 
ATOM   744  C C   . PRO A 1 98  ? 13.28505  -8.41095  58.05381  1.000 14.25192 ? 98  PRO A C   1 
ATOM   745  O O   . PRO A 1 98  ? 14.38290  -8.95673  58.20706  1.000 19.37692 ? 98  PRO A O   1 
ATOM   746  C CB  . PRO A 1 98  ? 11.37605  -8.95117  59.59267  1.000 15.46626 ? 98  PRO A CB  1 
ATOM   747  C CG  . PRO A 1 98  ? 10.83818  -10.29513 60.00790  1.000 18.20467 ? 98  PRO A CG  1 
ATOM   748  C CD  . PRO A 1 98  ? 11.76884  -11.29230 59.37734  1.000 14.08052 ? 98  PRO A CD  1 
ATOM   749  N N   . LEU A 1 99  ? 13.14111  -7.11394  57.77510  1.000 14.63449 ? 99  LEU A N   1 
ATOM   750  C CA  . LEU A 1 99  ? 14.26258  -6.18427  57.85064  1.000 12.82997 ? 99  LEU A CA  1 
ATOM   751  C C   . LEU A 1 99  ? 14.86328  -6.19344  59.25125  1.000 17.68163 ? 99  LEU A C   1 
ATOM   752  O O   . LEU A 1 99  ? 14.14981  -6.31121  60.25011  1.000 18.13643 ? 99  LEU A O   1 
ATOM   753  C CB  . LEU A 1 99  ? 13.80145  -4.76819  57.48925  1.000 12.16164 ? 99  LEU A CB  1 
ATOM   754  C CG  . LEU A 1 99  ? 13.07591  -4.62916  56.14224  1.000 11.91225 ? 99  LEU A CG  1 
ATOM   755  C CD1 . LEU A 1 99  ? 12.54317  -3.21817  55.95283  1.000 12.45407 ? 99  LEU A CD1 1 
ATOM   756  C CD2 . LEU A 1 99  ? 14.01306  -4.98598  54.99992  1.000 10.22217 ? 99  LEU A CD2 1 
ATOM   757  N N   . SER A 1 100 ? 16.17969  -6.04505  59.32229  1.000 17.83359 ? 100 SER A N   1 
ATOM   758  C CA  . SER A 1 100 ? 16.86178  -6.06318  60.60321  1.000 19.13566 ? 100 SER A CA  1 
ATOM   759  C C   . SER A 1 100 ? 16.49158  -4.83819  61.43304  1.000 30.12441 ? 100 SER A C   1 
ATOM   760  O O   . SER A 1 100 ? 15.97582  -3.82717  60.93447  1.000 15.15611 ? 100 SER A O   1 
ATOM   761  C CB  . SER A 1 100 ? 18.37659  -6.12197  60.40776  1.000 19.42028 ? 100 SER A CB  1 
ATOM   762  O OG  . SER A 1 100 ? 18.88802  -4.85410  60.01796  1.000 22.47986 ? 100 SER A OG  1 
ATOM   763  N N   . ARG A 1 101 ? 16.74748  -4.95342  62.73564  1.000 26.73340 ? 101 ARG A N   1 
ATOM   764  C CA  . ARG A 1 101 ? 16.51980  -3.82956  63.63001  1.000 27.07703 ? 101 ARG A CA  1 
ATOM   765  C C   . ARG A 1 101 ? 17.34340  -2.62095  63.20282  1.000 10.40842 ? 101 ARG A C   1 
ATOM   766  O O   . ARG A 1 101 ? 16.85111  -1.49389  63.23368  1.000 13.86016 ? 101 ARG A O   1 
ATOM   767  C CB  . ARG A 1 101 ? 16.81918  -4.24885  65.08048  1.000 26.96735 ? 101 ARG A CB  1 
ATOM   768  C CG  . ARG A 1 101 ? 17.50883  -3.21990  65.94859  1.000 40.22655 ? 101 ARG A CG  1 
ATOM   769  C CD  . ARG A 1 101 ? 17.70281  -3.76476  67.37960  1.000 44.79530 ? 101 ARG A CD  1 
ATOM   770  N NE  . ARG A 1 101 ? 16.47874  -3.63573  68.16276  1.000 46.64104 ? 101 ARG A NE  1 
ATOM   771  C CZ  . ARG A 1 101 ? 16.33264  -2.84595  69.21843  1.000 46.40826 ? 101 ARG A CZ  1 
ATOM   772  N NH1 . ARG A 1 101 ? 17.35578  -2.18852  69.73876  1.000 58.23325 ? 101 ARG A NH1 1 
ATOM   773  N NH2 . ARG A 1 101 ? 15.12812  -2.70743  69.76165  1.000 36.70349 ? 101 ARG A NH2 1 
ATOM   774  N N   . THR A 1 102 ? 18.58293  -2.83087  62.75906  1.000 14.82329 ? 102 THR A N   1 
ATOM   775  C CA  . THR A 1 102 ? 19.39460  -1.67253  62.40773  1.000 20.90555 ? 102 THR A CA  1 
ATOM   776  C C   . THR A 1 102 ? 19.06355  -1.11638  61.02155  1.000 15.13355 ? 102 THR A C   1 
ATOM   777  O O   . THR A 1 102 ? 19.32729  0.06618   60.77091  1.000 15.42454 ? 102 THR A O   1 
ATOM   778  C CB  . THR A 1 102 ? 20.88920  -1.98798  62.50027  1.000 23.43489 ? 102 THR A CB  1 
ATOM   779  O OG1 . THR A 1 102 ? 21.20238  -3.16660  61.74485  1.000 20.96234 ? 102 THR A OG1 1 
ATOM   780  C CG2 . THR A 1 102 ? 21.32024  -2.15582  63.97077  1.000 27.66591 ? 102 THR A CG2 1 
ATOM   781  N N   . THR A 1 103 ? 18.47141  -1.92001  60.13327  1.000 13.03380 ? 103 THR A N   1 
ATOM   782  C CA  . THR A 1 103 ? 17.89047  -1.35803  58.90965  1.000 13.58511 ? 103 THR A CA  1 
ATOM   783  C C   . THR A 1 103 ? 16.77825  -0.37124  59.24968  1.000 14.60162 ? 103 THR A C   1 
ATOM   784  O O   . THR A 1 103 ? 16.78144  0.77933   58.79519  1.000 16.04542 ? 103 THR A O   1 
ATOM   785  C CB  . THR A 1 103 ? 17.34353  -2.47492  58.01583  1.000 13.72688 ? 103 THR A CB  1 
ATOM   786  O OG1 . THR A 1 103 ? 18.39523  -3.36906  57.65854  1.000 12.13669 ? 103 THR A OG1 1 
ATOM   787  C CG2 . THR A 1 103 ? 16.71803  -1.88952  56.74225  1.000 13.05163 ? 103 THR A CG2 1 
ATOM   788  N N   . LEU A 1 104 ? 15.83444  -0.80075  60.08907  1.000 13.27059 ? 104 LEU A N   1 
ATOM   789  C CA  . LEU A 1 104 ? 14.67381  0.01681   60.42311  1.000 14.35025 ? 104 LEU A CA  1 
ATOM   790  C C   . LEU A 1 104 ? 15.06003  1.25038   61.23268  1.000 22.23342 ? 104 LEU A C   1 
ATOM   791  O O   . LEU A 1 104 ? 14.43598  2.30988   61.09486  1.000 14.42410 ? 104 LEU A O   1 
ATOM   792  C CB  . LEU A 1 104 ? 13.65937  -0.82728  61.18985  1.000 16.25579 ? 104 LEU A CB  1 
ATOM   793  C CG  . LEU A 1 104 ? 12.98309  -1.96059  60.42754  1.000 28.69841 ? 104 LEU A CG  1 
ATOM   794  C CD1 . LEU A 1 104 ? 12.33297  -2.93219  61.40512  1.000 19.61958 ? 104 LEU A CD1 1 
ATOM   795  C CD2 . LEU A 1 104 ? 11.94493  -1.38824  59.46099  1.000 19.02006 ? 104 LEU A CD2 1 
ATOM   796  N N   . ALA A 1 105 ? 16.06385  1.12632   62.10731  1.000 16.79868 ? 105 ALA A N   1 
ATOM   797  C CA  . ALA A 1 105 ? 16.51769  2.27289   62.87609  1.000 17.48857 ? 105 ALA A CA  1 
ATOM   798  C C   . ALA A 1 105 ? 17.23244  3.30306   62.01166  1.000 19.63192 ? 105 ALA A C   1 
ATOM   799  O O   . ALA A 1 105 ? 17.33895  4.46877   62.40914  1.000 18.40863 ? 105 ALA A O   1 
ATOM   800  C CB  . ALA A 1 105 ? 17.44631  1.81349   64.00761  1.000 18.88127 ? 105 ALA A CB  1 
ATOM   801  N N   . ASN A 1 106 ? 17.72374  2.91044   60.85173  1.000 14.74754 ? 106 ASN A N   1 
ATOM   802  C CA  . ASN A 1 106 ? 18.47392  3.83562   60.01682  1.000 15.55157 ? 106 ASN A CA  1 
ATOM   803  C C   . ASN A 1 106 ? 17.53341  4.88232   59.43108  1.000 19.79818 ? 106 ASN A C   1 
ATOM   804  O O   . ASN A 1 106 ? 16.67827  4.53680   58.60819  1.000 14.73883 ? 106 ASN A O   1 
ATOM   805  C CB  . ASN A 1 106 ? 19.18408  3.08401   58.90709  1.000 12.22763 ? 106 ASN A CB  1 
ATOM   806  C CG  . ASN A 1 106 ? 20.22850  3.93404   58.20004  1.000 12.95510 ? 106 ASN A CG  1 
ATOM   807  O OD1 . ASN A 1 106 ? 20.08748  5.13859   58.10184  1.000 14.12461 ? 106 ASN A OD1 1 
ATOM   808  N ND2 . ASN A 1 106 ? 21.28312  3.29805   57.70984  1.000 11.48356 ? 106 ASN A ND2 1 
ATOM   809  N N   . PRO A 1 107 ? 17.68681  6.16204   59.78672  1.000 16.91340 ? 107 PRO A N   1 
ATOM   810  C CA  . PRO A 1 107 ? 16.79303  7.19555   59.24153  1.000 22.25279 ? 107 PRO A CA  1 
ATOM   811  C C   . PRO A 1 107 ? 16.84965  7.29795   57.72717  1.000 20.34566 ? 107 PRO A C   1 
ATOM   812  O O   . PRO A 1 107 ? 15.88978  7.77860   57.11834  1.000 13.36772 ? 107 PRO A O   1 
ATOM   813  C CB  . PRO A 1 107 ? 17.30341  8.48600   59.90696  1.000 24.43128 ? 107 PRO A CB  1 
ATOM   814  C CG  . PRO A 1 107 ? 18.75594  8.21716   60.14777  1.000 23.23794 ? 107 PRO A CG  1 
ATOM   815  C CD  . PRO A 1 107 ? 18.86318  6.73743   60.45689  1.000 18.77147 ? 107 PRO A CD  1 
ATOM   816  N N   . LEU A 1 108 ? 17.93548  6.85446   57.09695  1.000 12.76438 ? 108 LEU A N   1 
ATOM   817  C CA  . LEU A 1 108 ? 17.98217  6.90766   55.64323  1.000 12.24715 ? 108 LEU A CA  1 
ATOM   818  C C   . LEU A 1 108 ? 16.91115  6.02032   55.01416  1.000 14.11382 ? 108 LEU A C   1 
ATOM   819  O O   . LEU A 1 108 ? 16.47145  6.29403   53.89625  1.000 15.50591 ? 108 LEU A O   1 
ATOM   820  C CB  . LEU A 1 108 ? 19.37073  6.51001   55.13738  1.000 10.27143 ? 108 LEU A CB  1 
ATOM   821  C CG  . LEU A 1 108 ? 19.54159  6.45554   53.60806  1.000 12.34858 ? 108 LEU A CG  1 
ATOM   822  C CD1 . LEU A 1 108 ? 19.25204  7.81079   52.95892  1.000 13.47397 ? 108 LEU A CD1 1 
ATOM   823  C CD2 . LEU A 1 108 ? 20.93813  5.93897   53.22218  1.000 9.26309  ? 108 LEU A CD2 1 
ATOM   824  N N   . LEU A 1 109 ? 16.47262  4.95796   55.70126  1.000 13.90673 ? 109 LEU A N   1 
ATOM   825  C CA  . LEU A 1 109 ? 15.45089  4.10058   55.10027  1.000 10.12482 ? 109 LEU A CA  1 
ATOM   826  C C   . LEU A 1 109 ? 14.13486  4.85310   54.95211  1.000 13.48261 ? 109 LEU A C   1 
ATOM   827  O O   . LEU A 1 109 ? 13.50719  4.82070   53.89143  1.000 13.77203 ? 109 LEU A O   1 
ATOM   828  C CB  . LEU A 1 109 ? 15.24853  2.81961   55.91417  1.000 9.71103  ? 109 LEU A CB  1 
ATOM   829  C CG  . LEU A 1 109 ? 14.21065  1.87043   55.27110  1.000 18.15583 ? 109 LEU A CG  1 
ATOM   830  C CD1 . LEU A 1 109 ? 14.75390  1.19329   53.99365  1.000 16.69847 ? 109 LEU A CD1 1 
ATOM   831  C CD2 . LEU A 1 109 ? 13.67208  0.83973   56.26432  1.000 13.79757 ? 109 LEU A CD2 1 
ATOM   832  N N   . THR A 1 110 ? 13.72483  5.57818   55.99537  1.000 13.64605 ? 110 THR A N   1 
ATOM   833  C CA  . THR A 1 110 ? 12.49602  6.37114   55.93522  1.000 13.19389 ? 110 THR A CA  1 
ATOM   834  C C   . THR A 1 110 ? 12.65946  7.57524   55.01434  1.000 15.36216 ? 110 THR A C   1 
ATOM   835  O O   . THR A 1 110 ? 11.71844  7.96008   54.30559  1.000 19.42228 ? 110 THR A O   1 
ATOM   836  C CB  . THR A 1 110 ? 12.11680  6.81745   57.35365  1.000 16.09460 ? 110 THR A CB  1 
ATOM   837  O OG1 . THR A 1 110 ? 11.73126  5.67020   58.12497  1.000 23.19812 ? 110 THR A OG1 1 
ATOM   838  C CG2 . THR A 1 110 ? 10.98144  7.80013   57.34692  1.000 25.51151 ? 110 THR A CG2 1 
ATOM   839  N N   . ARG A 1 111 ? 13.85080  8.17703   55.00569  1.000 15.44230 ? 111 ARG A N   1 
ATOM   840  C CA  . ARG A 1 111 ? 14.11841  9.29599   54.10994  1.000 20.67731 ? 111 ARG A CA  1 
ATOM   841  C C   . ARG A 1 111 ? 13.96945  8.88596   52.65477  1.000 18.73330 ? 111 ARG A C   1 
ATOM   842  O O   . ARG A 1 111 ? 13.33057  9.59824   51.86487  1.000 13.54956 ? 111 ARG A O   1 
ATOM   843  C CB  . ARG A 1 111 ? 15.52297  9.84810   54.35904  1.000 17.93842 ? 111 ARG A CB  1 
ATOM   844  C CG  . ARG A 1 111 ? 15.90767  10.97770  53.41972  1.000 25.82627 ? 111 ARG A CG  1 
ATOM   845  C CD  . ARG A 1 111 ? 17.29538  11.54614  53.73704  1.000 39.92709 ? 111 ARG A CD  1 
ATOM   846  N NE  . ARG A 1 111 ? 17.56383  12.76389  52.97897  1.000 45.30382 ? 111 ARG A NE  1 
ATOM   847  C CZ  . ARG A 1 111 ? 18.62901  13.53589  53.14771  1.000 50.54635 ? 111 ARG A CZ  1 
ATOM   848  N NH1 . ARG A 1 111 ? 19.56435  13.23990  54.03753  1.000 51.76681 ? 111 ARG A NH1 1 
ATOM   849  N NH2 . ARG A 1 111 ? 18.75730  14.63472  52.40808  1.000 56.53525 ? 111 ARG A NH2 1 
ATOM   850  N N   . LEU A 1 112 ? 14.58656  7.75469   52.27653  1.000 11.01396 ? 112 LEU A N   1 
ATOM   851  C CA  . LEU A 1 112 ? 14.48795  7.27084   50.90455  1.000 13.48676 ? 112 LEU A CA  1 
ATOM   852  C C   . LEU A 1 112 ? 13.05340  6.90637   50.55900  1.000 12.73855 ? 112 LEU A C   1 
ATOM   853  O O   . LEU A 1 112 ? 12.58483  7.20566   49.45758  1.000 12.44580 ? 112 LEU A O   1 
ATOM   854  C CB  . LEU A 1 112 ? 15.41708  6.06035   50.68488  1.000 13.96558 ? 112 LEU A CB  1 
ATOM   855  C CG  . LEU A 1 112 ? 16.94118  6.27623   50.58988  1.000 11.68677 ? 112 LEU A CG  1 
ATOM   856  C CD1 . LEU A 1 112 ? 17.72435  4.95193   50.44784  1.000 12.83380 ? 112 LEU A CD1 1 
ATOM   857  C CD2 . LEU A 1 112 ? 17.31531  7.21436   49.45860  1.000 9.74488  ? 112 LEU A CD2 1 
ATOM   858  N N   . LEU A 1 113 ? 12.33975  6.24665   51.47359  1.000 8.97660  ? 113 LEU A N   1 
ATOM   859  C CA  . LEU A 1 113 ? 10.95141  5.90686   51.18934  1.000 10.57447 ? 113 LEU A CA  1 
ATOM   860  C C   . LEU A 1 113 ? 10.12932  7.15009   50.84221  1.000 20.50833 ? 113 LEU A C   1 
ATOM   861  O O   . LEU A 1 113 ? 9.32028   7.12779   49.90537  1.000 16.05054 ? 113 LEU A O   1 
ATOM   862  C CB  . LEU A 1 113 ? 10.33993  5.16829   52.38080  1.000 11.81653 ? 113 LEU A CB  1 
ATOM   863  C CG  . LEU A 1 113 ? 8.98314   4.51898   52.09534  1.000 14.81781 ? 113 LEU A CG  1 
ATOM   864  C CD1 . LEU A 1 113 ? 8.83000   3.24670   52.95394  1.000 12.29148 ? 113 LEU A CD1 1 
ATOM   865  C CD2 . LEU A 1 113 ? 7.78712   5.48965   52.30169  1.000 15.29097 ? 113 LEU A CD2 1 
ATOM   866  N N   . ARG A 1 114 ? 10.31582  8.24396   51.58805  1.000 12.82615 ? 114 ARG A N   1 
ATOM   867  C CA  . ARG A 1 114 ? 9.55748   9.46845   51.32773  1.000 16.84443 ? 114 ARG A CA  1 
ATOM   868  C C   . ARG A 1 114 ? 10.06434  10.20022  50.09213  1.000 14.84568 ? 114 ARG A C   1 
ATOM   869  O O   . ARG A 1 114 ? 9.26823   10.65821  49.26307  1.000 16.15701 ? 114 ARG A O   1 
ATOM   870  C CB  . ARG A 1 114 ? 9.63325   10.39702  52.53421  1.000 12.86790 ? 114 ARG A CB  1 
ATOM   871  C CG  . ARG A 1 114 ? 8.91313   9.89708   53.73775  1.000 11.07732 ? 114 ARG A CG  1 
ATOM   872  C CD  . ARG A 1 114 ? 9.28951   10.77440  54.91765  1.000 19.80300 ? 114 ARG A CD  1 
ATOM   873  N NE  . ARG A 1 114 ? 8.49048   10.46308  56.09046  1.000 15.88315 ? 114 ARG A NE  1 
ATOM   874  C CZ  . ARG A 1 114 ? 8.92244   10.59446  57.33748  1.000 28.56703 ? 114 ARG A CZ  1 
ATOM   875  N NH1 . ARG A 1 114 ? 10.14254  11.03749  57.60733  1.000 27.89344 ? 114 ARG A NH1 1 
ATOM   876  N NH2 . ARG A 1 114 ? 8.11379   10.26757  58.34046  1.000 26.79071 ? 114 ARG A NH2 1 
ATOM   877  N N   . ALA A 1 115 ? 11.38715  10.33383  49.97364  1.000 13.83167 ? 115 ALA A N   1 
ATOM   878  C CA  . ALA A 1 115 ? 11.98571  11.10599  48.88977  1.000 12.13762 ? 115 ALA A CA  1 
ATOM   879  C C   . ALA A 1 115 ? 11.79566  10.43816  47.53883  1.000 19.15665 ? 115 ALA A C   1 
ATOM   880  O O   . ALA A 1 115 ? 11.61316  11.13118  46.53189  1.000 19.35500 ? 115 ALA A O   1 
ATOM   881  C CB  . ALA A 1 115 ? 13.47809  11.31681  49.14876  1.000 18.51879 ? 115 ALA A CB  1 
ATOM   882  N N   . ASP A 1 116 ? 11.86704  9.10043   47.48050  1.000 13.28873 ? 116 ASP A N   1 
ATOM   883  C CA  . ASP A 1 116 ? 11.71153  8.43111   46.18971  1.000 14.28388 ? 116 ASP A CA  1 
ATOM   884  C C   . ASP A 1 116 ? 10.32978  8.69889   45.61767  1.000 17.84969 ? 116 ASP A C   1 
ATOM   885  O O   . ASP A 1 116 ? 10.17967  8.87435   44.40400  1.000 11.58439 ? 116 ASP A O   1 
ATOM   886  C CB  . ASP A 1 116 ? 11.92816  6.91807   46.31048  1.000 9.46010  ? 116 ASP A CB  1 
ATOM   887  C CG  . ASP A 1 116 ? 13.37898  6.54894   46.60786  1.000 12.27005 ? 116 ASP A CG  1 
ATOM   888  O OD1 . ASP A 1 116 ? 14.29147  7.35316   46.34331  1.000 9.88957  ? 116 ASP A OD1 1 
ATOM   889  O OD2 . ASP A 1 116 ? 13.59713  5.44017   47.11727  1.000 12.32558 ? 116 ASP A OD2 1 
ATOM   890  N N   . PHE A 1 117 ? 9.31042   8.73851   46.48762  1.000 11.51906 ? 117 PHE A N   1 
ATOM   891  C CA  . PHE A 1 117 ? 7.93343   8.91292   46.03846  1.000 13.46406 ? 117 PHE A CA  1 
ATOM   892  C C   . PHE A 1 117 ? 7.76504   10.18541  45.21832  1.000 14.82619 ? 117 PHE A C   1 
ATOM   893  O O   . PHE A 1 117 ? 6.93136   10.23293  44.30960  1.000 13.01365 ? 117 PHE A O   1 
ATOM   894  C CB  . PHE A 1 117 ? 6.99290   8.91558   47.24457  1.000 16.59245 ? 117 PHE A CB  1 
ATOM   895  C CG  . PHE A 1 117 ? 5.55058   8.99307   46.86523  1.000 16.13665 ? 117 PHE A CG  1 
ATOM   896  C CD1 . PHE A 1 117 ? 4.85019   7.85379   46.52555  1.000 9.78282  ? 117 PHE A CD1 1 
ATOM   897  C CD2 . PHE A 1 117 ? 4.91356   10.21545  46.79845  1.000 16.35272 ? 117 PHE A CD2 1 
ATOM   898  C CE1 . PHE A 1 117 ? 3.52338   7.93010   46.15689  1.000 17.55744 ? 117 PHE A CE1 1 
ATOM   899  C CE2 . PHE A 1 117 ? 3.59999   10.29675  46.42266  1.000 17.22185 ? 117 PHE A CE2 1 
ATOM   900  C CZ  . PHE A 1 117 ? 2.89978   9.14569   46.10056  1.000 16.60121 ? 117 PHE A CZ  1 
ATOM   901  N N   A GLU A 1 118 ? 8.55569   11.21732  45.50152  0.601 16.80666 ? 118 GLU A N   1 
ATOM   902  N N   B GLU A 1 118 ? 8.55484   11.21621  45.51782  0.399 16.85270 ? 118 GLU A N   1 
ATOM   903  C CA  A GLU A 1 118 ? 8.38782   12.49312  44.82055  0.601 20.27099 ? 118 GLU A CA  1 
ATOM   904  C CA  B GLU A 1 118 ? 8.43659   12.49871  44.83734  0.399 20.24981 ? 118 GLU A CA  1 
ATOM   905  C C   A GLU A 1 118 ? 8.81740   12.45907  43.35852  0.601 22.35374 ? 118 GLU A C   1 
ATOM   906  C C   B GLU A 1 118 ? 8.67764   12.38911  43.33511  0.399 22.22850 ? 118 GLU A C   1 
ATOM   907  O O   A GLU A 1 118 ? 8.62022   13.45240  42.65277  0.601 22.82935 ? 118 GLU A O   1 
ATOM   908  O O   B GLU A 1 118 ? 8.18602   13.23207  42.57617  0.399 22.04033 ? 118 GLU A O   1 
ATOM   909  C CB  A GLU A 1 118 ? 9.16135   13.58651  45.56457  0.601 20.96454 ? 118 GLU A CB  1 
ATOM   910  C CB  B GLU A 1 118 ? 9.41415   13.49497  45.47703  0.399 20.43271 ? 118 GLU A CB  1 
ATOM   911  C CG  A GLU A 1 118 ? 8.65212   13.84850  46.98581  0.601 19.13358 ? 118 GLU A CG  1 
ATOM   912  C CG  B GLU A 1 118 ? 9.16128   13.70786  46.98104  0.399 19.14625 ? 118 GLU A CG  1 
ATOM   913  C CD  A GLU A 1 118 ? 7.16610   14.18425  47.03540  0.601 19.04748 ? 118 GLU A CD  1 
ATOM   914  C CD  B GLU A 1 118 ? 10.39166  14.18162  47.75065  0.399 22.87693 ? 118 GLU A CD  1 
ATOM   915  O OE1 A GLU A 1 118 ? 6.64088   14.75516  46.05964  0.601 27.37453 ? 118 GLU A OE1 1 
ATOM   916  O OE1 B GLU A 1 118 ? 11.43892  14.42984  47.12024  0.399 26.67007 ? 118 GLU A OE1 1 
ATOM   917  O OE2 A GLU A 1 118 ? 6.51493   13.87735  48.05589  0.601 20.91294 ? 118 GLU A OE2 1 
ATOM   918  O OE2 B GLU A 1 118 ? 10.31241  14.32214  48.99041  0.399 25.21478 ? 118 GLU A OE2 1 
ATOM   919  N N   . ASN A 1 119 ? 9.39541   11.35910  42.88468  1.000 20.24942 ? 119 ASN A N   1 
ATOM   920  C CA  . ASN A 1 119 ? 9.73819   11.22782  41.47574  1.000 17.27991 ? 119 ASN A CA  1 
ATOM   921  C C   . ASN A 1 119 ? 8.62490   10.59641  40.66030  1.000 13.84918 ? 119 ASN A C   1 
ATOM   922  O O   . ASN A 1 119 ? 8.77074   10.45642  39.44553  1.000 19.40134 ? 119 ASN A O   1 
ATOM   923  C CB  . ASN A 1 119 ? 11.02658  10.41245  41.33714  1.000 16.28575 ? 119 ASN A CB  1 
ATOM   924  C CG  . ASN A 1 119 ? 12.19899  11.09045  41.99060  1.000 11.40584 ? 119 ASN A CG  1 
ATOM   925  O OD1 . ASN A 1 119 ? 12.86253  11.90696  41.37368  1.000 20.18516 ? 119 ASN A OD1 1 
ATOM   926  N ND2 . ASN A 1 119 ? 12.45766  10.76719  43.25047  1.000 15.53270 ? 119 ASN A ND2 1 
ATOM   927  N N   . PHE A 1 120 ? 7.52919   10.21266  41.29018  1.000 10.30175 ? 120 PHE A N   1 
ATOM   928  C CA  . PHE A 1 120 ? 6.52800   9.48190   40.53999  1.000 13.56674 ? 120 PHE A CA  1 
ATOM   929  C C   . PHE A 1 120 ? 5.44228   10.44165  40.05363  1.000 20.89419 ? 120 PHE A C   1 
ATOM   930  O O   . PHE A 1 120 ? 5.04045   11.34067  40.79283  1.000 13.53366 ? 120 PHE A O   1 
ATOM   931  C CB  . PHE A 1 120 ? 5.89399   8.39848   41.40986  1.000 10.96285 ? 120 PHE A CB  1 
ATOM   932  C CG  . PHE A 1 120 ? 6.87651   7.41971   42.01287  1.000 10.60184 ? 120 PHE A CG  1 
ATOM   933  C CD1 . PHE A 1 120 ? 7.96067   6.94373   41.28043  1.000 10.35713 ? 120 PHE A CD1 1 
ATOM   934  C CD2 . PHE A 1 120 ? 6.67467   6.93955   43.30903  1.000 15.48337 ? 120 PHE A CD2 1 
ATOM   935  C CE1 . PHE A 1 120 ? 8.85292   6.00892   41.85010  1.000 13.62424 ? 120 PHE A CE1 1 
ATOM   936  C CE2 . PHE A 1 120 ? 7.54490   6.01441   43.88489  1.000 13.23607 ? 120 PHE A CE2 1 
ATOM   937  C CZ  . PHE A 1 120 ? 8.64449   5.54565   43.13755  1.000 9.64481  ? 120 PHE A CZ  1 
ATOM   938  N N   . PRO A 1 121 ? 4.96688   10.29187  38.82072  1.000 19.51150 ? 121 PRO A N   1 
ATOM   939  C CA  . PRO A 1 121 ? 3.82530   11.10537  38.36892  1.000 23.91536 ? 121 PRO A CA  1 
ATOM   940  C C   . PRO A 1 121 ? 2.51463   10.58158  38.92672  1.000 21.17444 ? 121 PRO A C   1 
ATOM   941  O O   . PRO A 1 121 ? 1.90797   9.66647   38.36206  1.000 22.74124 ? 121 PRO A O   1 
ATOM   942  C CB  . PRO A 1 121 ? 3.89025   10.98183  36.83984  1.000 23.62240 ? 121 PRO A CB  1 
ATOM   943  C CG  . PRO A 1 121 ? 4.51702   9.62625   36.61023  1.000 21.87765 ? 121 PRO A CG  1 
ATOM   944  C CD  . PRO A 1 121 ? 5.53332   9.47459   37.73471  1.000 16.81233 ? 121 PRO A CD  1 
ATOM   945  N N   . VAL A 1 122 ? 2.07864   11.13088  40.05614  1.000 20.69328 ? 122 VAL A N   1 
ATOM   946  C CA  . VAL A 1 122 ? 0.84174   10.68384  40.68902  1.000 25.49941 ? 122 VAL A CA  1 
ATOM   947  C C   . VAL A 1 122 ? -0.33739  11.20916  39.87612  1.000 35.33947 ? 122 VAL A C   1 
ATOM   948  O O   . VAL A 1 122 ? -0.50786  12.42949  39.74075  1.000 31.51726 ? 122 VAL A O   1 
ATOM   949  C CB  . VAL A 1 122 ? 0.77642   11.13504  42.15375  1.000 27.28517 ? 122 VAL A CB  1 
ATOM   950  C CG1 . VAL A 1 122 ? -0.47013  10.60662  42.80238  1.000 22.59532 ? 122 VAL A CG1 1 
ATOM   951  C CG2 . VAL A 1 122 ? 2.01361   10.63341  42.90216  1.000 30.51670 ? 122 VAL A CG2 1 
ATOM   952  N N   . PRO A 1 123 ? -1.17049  10.33123  39.31592  1.000 28.09404 ? 123 PRO A N   1 
ATOM   953  C CA  . PRO A 1 123 ? -2.14799  10.78572  38.31820  1.000 44.49569 ? 123 PRO A CA  1 
ATOM   954  C C   . PRO A 1 123 ? -3.33735  11.52956  38.90785  1.000 45.83513 ? 123 PRO A C   1 
ATOM   955  O O   . PRO A 1 123 ? -4.00433  12.25902  38.16714  1.000 45.45313 ? 123 PRO A O   1 
ATOM   956  C CB  . PRO A 1 123 ? -2.58852  9.47843   37.65045  1.000 36.66855 ? 123 PRO A CB  1 
ATOM   957  C CG  . PRO A 1 123 ? -2.47989  8.46524   38.75450  1.000 35.32912 ? 123 PRO A CG  1 
ATOM   958  C CD  . PRO A 1 123 ? -1.27125  8.88419   39.57283  1.000 34.93367 ? 123 PRO A CD  1 
ATOM   959  N N   . GLU A 1 124 ? -3.63156  11.36459  40.19966  1.000 49.75454 ? 124 GLU A N   1 
ATOM   960  C CA  . GLU A 1 124 ? -4.75858  12.02688  40.85560  1.000 33.87433 ? 124 GLU A CA  1 
ATOM   961  C C   . GLU A 1 124 ? -4.27471  12.61276  42.17453  1.000 42.36391 ? 124 GLU A C   1 
ATOM   962  O O   . GLU A 1 124 ? -3.76342  11.87867  43.02621  1.000 34.24826 ? 124 GLU A O   1 
ATOM   963  C CB  . GLU A 1 124 ? -5.91406  11.05110  41.10186  1.000 29.22315 ? 124 GLU A CB  1 
ATOM   964  C CG  . GLU A 1 124 ? -6.40542  10.29659  39.85974  1.000 41.54440 ? 124 GLU A CG  1 
ATOM   965  C CD  . GLU A 1 124 ? -7.11852  11.18755  38.84667  1.000 39.59454 ? 124 GLU A CD  1 
ATOM   966  O OE1 . GLU A 1 124 ? -7.58107  12.27632  39.23511  1.000 33.02035 ? 124 GLU A OE1 1 
ATOM   967  O OE2 . GLU A 1 124 ? -7.21072  10.79022  37.66048  1.000 40.98902 ? 124 GLU A OE2 1 
ATOM   968  N N   . GLU A 1 125 ? -4.43792  13.93055  42.34312  1.000 38.75742 ? 125 GLU A N   1 
ATOM   969  C CA  . GLU A 1 125 ? -3.96416  14.59417  43.55679  1.000 37.75309 ? 125 GLU A CA  1 
ATOM   970  C C   . GLU A 1 125 ? -4.54820  13.96914  44.82170  1.000 32.83543 ? 125 GLU A C   1 
ATOM   971  O O   . GLU A 1 125 ? -3.87499  13.91496  45.85875  1.000 38.38514 ? 125 GLU A O   1 
ATOM   972  C CB  . GLU A 1 125 ? -4.29318  16.08698  43.48185  1.000 39.01591 ? 125 GLU A CB  1 
ATOM   973  C CG  . GLU A 1 125 ? -4.21870  16.83372  44.79908  1.000 48.18077 ? 125 GLU A CG  1 
ATOM   974  C CD  . GLU A 1 125 ? -2.93685  17.62071  44.95544  1.000 53.24117 ? 125 GLU A CD  1 
ATOM   975  O OE1 . GLU A 1 125 ? -2.29236  17.92732  43.92702  1.000 56.56350 ? 125 GLU A OE1 1 
ATOM   976  O OE2 . GLU A 1 125 ? -2.57441  17.93170  46.11164  1.000 52.67822 ? 125 GLU A OE2 1 
ATOM   977  N N   . SER A 1 126 ? -5.77706  13.45587  44.75310  1.000 32.78626 ? 126 SER A N   1 
ATOM   978  C CA  . SER A 1 126 ? -6.40017  12.89534  45.94485  1.000 35.75014 ? 126 SER A CA  1 
ATOM   979  C C   . SER A 1 126 ? -5.61612  11.71039  46.49968  1.000 35.79443 ? 126 SER A C   1 
ATOM   980  O O   . SER A 1 126 ? -5.76741  11.37994  47.68294  1.000 28.75196 ? 126 SER A O   1 
ATOM   981  C CB  . SER A 1 126 ? -7.84733  12.48277  45.64796  1.000 31.30211 ? 126 SER A CB  1 
ATOM   982  O OG  . SER A 1 126 ? -7.94496  11.15575  45.15292  1.000 28.73497 ? 126 SER A OG  1 
ATOM   983  N N   . TRP A 1 127 ? -4.77362  11.07626  45.67739  1.000 31.56545 ? 127 TRP A N   1 
ATOM   984  C CA  . TRP A 1 127 ? -4.00153  9.92073   46.12663  1.000 25.97789 ? 127 TRP A CA  1 
ATOM   985  C C   . TRP A 1 127 ? -2.97169  10.28389  47.18538  1.000 20.43651 ? 127 TRP A C   1 
ATOM   986  O O   . TRP A 1 127 ? -2.58491  9.41935   47.97679  1.000 21.53733 ? 127 TRP A O   1 
ATOM   987  C CB  . TRP A 1 127 ? -3.31087  9.25814   44.93529  1.000 20.26458 ? 127 TRP A CB  1 
ATOM   988  C CG  . TRP A 1 127 ? -4.27904  8.64540   43.95703  1.000 26.43214 ? 127 TRP A CG  1 
ATOM   989  C CD1 . TRP A 1 127 ? -5.62577  8.89400   43.85848  1.000 30.69809 ? 127 TRP A CD1 1 
ATOM   990  C CD2 . TRP A 1 127 ? -3.98114  7.67609   42.94901  1.000 34.43609 ? 127 TRP A CD2 1 
ATOM   991  N NE1 . TRP A 1 127 ? -6.17633  8.14708   42.84814  1.000 28.05566 ? 127 TRP A NE1 1 
ATOM   992  C CE2 . TRP A 1 127 ? -5.18822  7.39111   42.27075  1.000 32.77332 ? 127 TRP A CE2 1 
ATOM   993  C CE3 . TRP A 1 127 ? -2.81294  7.02252   42.54827  1.000 22.70484 ? 127 TRP A CE3 1 
ATOM   994  C CZ2 . TRP A 1 127 ? -5.25616  6.47846   41.22243  1.000 34.50633 ? 127 TRP A CZ2 1 
ATOM   995  C CZ3 . TRP A 1 127 ? -2.88388  6.12077   41.50404  1.000 24.52914 ? 127 TRP A CZ3 1 
ATOM   996  C CH2 . TRP A 1 127 ? -4.09550  5.85589   40.85156  1.000 38.76456 ? 127 TRP A CH2 1 
ATOM   997  N N   . LEU A 1 128 ? -2.52976  11.54022  47.23065  1.000 24.32590 ? 128 LEU A N   1 
ATOM   998  C CA  . LEU A 1 128 ? -1.57080  11.94770  48.24793  1.000 24.70588 ? 128 LEU A CA  1 
ATOM   999  C C   . LEU A 1 128 ? -2.13417  11.86730  49.65719  1.000 30.34073 ? 128 LEU A C   1 
ATOM   1000 O O   . LEU A 1 128 ? -1.35205  11.85331  50.61716  1.000 32.09747 ? 128 LEU A O   1 
ATOM   1001 C CB  . LEU A 1 128 ? -1.09398  13.36204  47.98112  1.000 29.80681 ? 128 LEU A CB  1 
ATOM   1002 C CG  . LEU A 1 128 ? -0.42285  13.56476  46.63580  1.000 29.98933 ? 128 LEU A CG  1 
ATOM   1003 C CD1 . LEU A 1 128 ? 0.00818   15.01345  46.52841  1.000 22.78112 ? 128 LEU A CD1 1 
ATOM   1004 C CD2 . LEU A 1 128 ? 0.75834   12.62197  46.51446  1.000 35.39445 ? 128 LEU A CD2 1 
ATOM   1005 N N   . ASP A 1 129 ? -3.46216  11.83931  49.80337  1.000 29.42634 ? 129 ASP A N   1 
ATOM   1006 C CA  . ASP A 1 129 ? -4.11966  11.72552  51.09866  1.000 29.74596 ? 129 ASP A CA  1 
ATOM   1007 C C   . ASP A 1 129 ? -4.51358  10.29954  51.42630  1.000 28.32695 ? 129 ASP A C   1 
ATOM   1008 O O   . ASP A 1 129 ? -4.96927  10.04150  52.54110  1.000 31.66603 ? 129 ASP A O   1 
ATOM   1009 C CB  . ASP A 1 129 ? -5.37781  12.60712  51.14227  1.000 32.47218 ? 129 ASP A CB  1 
ATOM   1010 C CG  . ASP A 1 129 ? -5.07362  14.05997  50.86819  1.000 41.77988 ? 129 ASP A CG  1 
ATOM   1011 O OD1 . ASP A 1 129 ? -4.25260  14.63937  51.60644  1.000 37.72742 ? 129 ASP A OD1 1 
ATOM   1012 O OD2 . ASP A 1 129 ? -5.62490  14.61411  49.88756  1.000 46.22554 ? 129 ASP A OD2 1 
ATOM   1013 N N   . ASP A 1 130 ? -4.35779  9.38366   50.49111  1.000 22.57789 ? 130 ASP A N   1 
ATOM   1014 C CA  . ASP A 1 130 ? -4.69787  7.99057   50.70442  1.000 21.81336 ? 130 ASP A CA  1 
ATOM   1015 C C   . ASP A 1 130 ? -3.48659  7.22389   51.21706  1.000 20.75596 ? 130 ASP A C   1 
ATOM   1016 O O   . ASP A 1 130 ? -2.34402  7.66731   51.05918  1.000 19.58963 ? 130 ASP A O   1 
ATOM   1017 C CB  . ASP A 1 130 ? -5.18956  7.37197   49.40068  1.000 28.08919 ? 130 ASP A CB  1 
ATOM   1018 C CG  . ASP A 1 130 ? -6.47523  8.00829   48.89584  1.000 28.28386 ? 130 ASP A CG  1 
ATOM   1019 O OD1 . ASP A 1 130 ? -7.41585  8.19270   49.69596  1.000 27.82108 ? 130 ASP A OD1 1 
ATOM   1020 O OD2 . ASP A 1 130 ? -6.53413  8.32467   47.69381  1.000 31.89298 ? 130 ASP A OD2 1 
ATOM   1021 N N   . PRO A 1 131 ? -3.71047  6.08280   51.86042  1.000 19.05566 ? 131 PRO A N   1 
ATOM   1022 C CA  . PRO A 1 131 ? -2.59417  5.19310   52.19651  1.000 23.13109 ? 131 PRO A CA  1 
ATOM   1023 C C   . PRO A 1 131 ? -2.01903  4.53575   50.95507  1.000 23.25195 ? 131 PRO A C   1 
ATOM   1024 O O   . PRO A 1 131 ? -2.72962  4.24276   49.99263  1.000 22.32903 ? 131 PRO A O   1 
ATOM   1025 C CB  . PRO A 1 131 ? -3.23195  4.13629   53.10378  1.000 19.83701 ? 131 PRO A CB  1 
ATOM   1026 C CG  . PRO A 1 131 ? -4.55167  4.71861   53.53241  1.000 33.42256 ? 131 PRO A CG  1 
ATOM   1027 C CD  . PRO A 1 131 ? -4.98689  5.61557   52.42514  1.000 22.97380 ? 131 PRO A CD  1 
ATOM   1028 N N   . TRP A 1 132 ? -0.71475  4.29031   51.00406  1.000 20.82344 ? 132 TRP A N   1 
ATOM   1029 C CA  . TRP A 1 132 ? -0.01110  3.49061   50.01270  1.000 22.36043 ? 132 TRP A CA  1 
ATOM   1030 C C   . TRP A 1 132 ? 0.68058   2.33898   50.71799  1.000 16.73909 ? 132 TRP A C   1 
ATOM   1031 O O   . TRP A 1 132 ? 1.27698   2.52005   51.78400  1.000 19.03167 ? 132 TRP A O   1 
ATOM   1032 C CB  . TRP A 1 132 ? 1.02567   4.31775   49.25907  1.000 14.55109 ? 132 TRP A CB  1 
ATOM   1033 C CG  . TRP A 1 132 ? 0.44922   5.37022   48.35686  1.000 17.58220 ? 132 TRP A CG  1 
ATOM   1034 C CD1 . TRP A 1 132 ? -0.33285  6.43692   48.72491  1.000 20.87507 ? 132 TRP A CD1 1 
ATOM   1035 C CD2 . TRP A 1 132 ? 0.64026   5.48672   46.94251  1.000 16.60791 ? 132 TRP A CD2 1 
ATOM   1036 N NE1 . TRP A 1 132 ? -0.64721  7.18564   47.62635  1.000 17.23191 ? 132 TRP A NE1 1 
ATOM   1037 C CE2 . TRP A 1 132 ? -0.06513  6.62581   46.51964  1.000 17.79239 ? 132 TRP A CE2 1 
ATOM   1038 C CE3 . TRP A 1 132 ? 1.33255   4.72997   45.98888  1.000 12.93746 ? 132 TRP A CE3 1 
ATOM   1039 C CZ2 . TRP A 1 132 ? -0.09012  7.03543   45.18667  1.000 15.74459 ? 132 TRP A CZ2 1 
ATOM   1040 C CZ3 . TRP A 1 132 ? 1.30025   5.13045   44.67269  1.000 15.10489 ? 132 TRP A CZ3 1 
ATOM   1041 C CH2 . TRP A 1 132 ? 0.59192   6.27362   44.27960  1.000 23.60745 ? 132 TRP A CH2 1 
ATOM   1042 N N   . ASP A 1 133 ? 0.61042   1.15288   50.13688  1.000 14.63749 ? 133 ASP A N   1 
ATOM   1043 C CA  . ASP A 1 133 ? 1.42940   0.06262   50.62751  1.000 11.37994 ? 133 ASP A CA  1 
ATOM   1044 C C   . ASP A 1 133 ? 2.78051   0.18553   49.94081  1.000 13.29431 ? 133 ASP A C   1 
ATOM   1045 O O   . ASP A 1 133 ? 2.82732   0.39529   48.73110  1.000 10.02040 ? 133 ASP A O   1 
ATOM   1046 C CB  . ASP A 1 133 ? 0.79025   -1.28419  50.33252  1.000 14.33805 ? 133 ASP A CB  1 
ATOM   1047 C CG  . ASP A 1 133 ? 1.69136   -2.43573  50.69639  1.000 21.92991 ? 133 ASP A CG  1 
ATOM   1048 O OD1 . ASP A 1 133 ? 2.00738   -2.59019  51.88876  1.000 26.71994 ? 133 ASP A OD1 1 
ATOM   1049 O OD2 . ASP A 1 133 ? 2.09506   -3.18766  49.78991  1.000 25.82199 ? 133 ASP A OD2 1 
ATOM   1050 N N   . VAL A 1 134 ? 3.86922   0.11722   50.71252  1.000 13.16869 ? 134 VAL A N   1 
ATOM   1051 C CA  . VAL A 1 134 ? 5.23159   0.21755   50.16358  1.000 11.05429 ? 134 VAL A CA  1 
ATOM   1052 C C   . VAL A 1 134 ? 5.97461   -1.05300  50.54051  1.000 11.54118 ? 134 VAL A C   1 
ATOM   1053 O O   . VAL A 1 134 ? 6.23419   -1.30384  51.72386  1.000 10.57916 ? 134 VAL A O   1 
ATOM   1054 C CB  . VAL A 1 134 ? 5.98857   1.45380   50.66518  1.000 12.87559 ? 134 VAL A CB  1 
ATOM   1055 C CG1 . VAL A 1 134 ? 7.37800   1.58640   49.94141  1.000 11.22051 ? 134 VAL A CG1 1 
ATOM   1056 C CG2 . VAL A 1 134 ? 5.17841   2.70440   50.43157  1.000 11.18270 ? 134 VAL A CG2 1 
ATOM   1057 N N   . GLN A 1 135 ? 6.26334   -1.88727  49.54921  1.000 8.24238  ? 135 GLN A N   1 
ATOM   1058 C CA  . GLN A 1 135 ? 6.97783   -3.12536  49.79800  1.000 12.64762 ? 135 GLN A CA  1 
ATOM   1059 C C   . GLN A 1 135 ? 8.44962   -2.81033  49.69895  1.000 9.17895  ? 135 GLN A C   1 
ATOM   1060 O O   . GLN A 1 135 ? 8.87629   -2.14960  48.75303  1.000 9.18699  ? 135 GLN A O   1 
ATOM   1061 C CB  . GLN A 1 135 ? 6.59025   -4.21177  48.79273  1.000 16.08285 ? 135 GLN A CB  1 
ATOM   1062 C CG  . GLN A 1 135 ? 5.15364   -4.67077  48.93564  1.000 20.97776 ? 135 GLN A CG  1 
ATOM   1063 C CD  . GLN A 1 135 ? 4.78593   -5.67412  47.86887  1.000 20.07343 ? 135 GLN A CD  1 
ATOM   1064 O OE1 . GLN A 1 135 ? 5.06748   -6.86745  47.99635  1.000 26.72397 ? 135 GLN A OE1 1 
ATOM   1065 N NE2 . GLN A 1 135 ? 4.16950   -5.19444  46.80401  1.000 19.93659 ? 135 GLN A NE2 1 
ATOM   1066 N N   . CYS A 1 136 ? 9.21813   -3.24775  50.68834  1.000 11.48745 ? 136 CYS A N   1 
ATOM   1067 C CA  . CYS A 1 136 ? 10.63143  -2.91573  50.77032  1.000 8.77427  ? 136 CYS A CA  1 
ATOM   1068 C C   . CYS A 1 136 ? 11.43359  -4.21193  50.75540  1.000 12.26650 ? 136 CYS A C   1 
ATOM   1069 O O   . CYS A 1 136 ? 11.26908  -5.05342  51.64151  1.000 10.21620 ? 136 CYS A O   1 
ATOM   1070 C CB  . CYS A 1 136 ? 10.88052  -2.10100  52.03547  1.000 8.60823  ? 136 CYS A CB  1 
ATOM   1071 S SG  . CYS A 1 136 ? 12.58214  -1.63276  52.35515  1.000 13.91055 ? 136 CYS A SG  1 
ATOM   1072 N N   . HIS A 1 137 ? 12.28013  -4.39001  49.73853  1.000 12.14987 ? 137 HIS A N   1 
ATOM   1073 C CA  . HIS A 1 137 ? 13.09304  -5.59692  49.61555  1.000 8.72788  ? 137 HIS A CA  1 
ATOM   1074 C C   . HIS A 1 137 ? 14.57490  -5.25673  49.68802  1.000 7.98028  ? 137 HIS A C   1 
ATOM   1075 O O   . HIS A 1 137 ? 15.05442  -4.39560  48.94623  1.000 9.50875  ? 137 HIS A O   1 
ATOM   1076 C CB  . HIS A 1 137 ? 12.84038  -6.31605  48.29421  1.000 12.57298 ? 137 HIS A CB  1 
ATOM   1077 C CG  . HIS A 1 137 ? 11.41089  -6.36423  47.87222  1.000 18.65195 ? 137 HIS A CG  1 
ATOM   1078 N ND1 . HIS A 1 137 ? 10.66750  -7.52515  47.90945  1.000 23.30308 ? 137 HIS A ND1 1 
ATOM   1079 C CD2 . HIS A 1 137 ? 10.59672  -5.40812  47.36218  1.000 15.12834 ? 137 HIS A CD2 1 
ATOM   1080 C CE1 . HIS A 1 137 ? 9.45046   -7.27830  47.45525  1.000 20.94116 ? 137 HIS A CE1 1 
ATOM   1081 N NE2 . HIS A 1 137 ? 9.38037   -6.00002  47.12345  1.000 24.51514 ? 137 HIS A NE2 1 
ATOM   1082 N N   . GLN A 1 138 ? 15.30328  -5.93714  50.55855  1.000 8.86060  ? 138 GLN A N   1 
ATOM   1083 C CA  . GLN A 1 138 ? 16.75541  -6.02558  50.43764  1.000 12.14254 ? 138 GLN A CA  1 
ATOM   1084 C C   . GLN A 1 138 ? 17.06252  -7.31636  49.68188  1.000 14.65171 ? 138 GLN A C   1 
ATOM   1085 O O   . GLN A 1 138 ? 16.65341  -8.39370  50.12648  1.000 13.34495 ? 138 GLN A O   1 
ATOM   1086 C CB  . GLN A 1 138 ? 17.43799  -6.02560  51.80964  1.000 8.10825  ? 138 GLN A CB  1 
ATOM   1087 C CG  . GLN A 1 138 ? 17.12690  -4.80332  52.65826  1.000 10.01189 ? 138 GLN A CG  1 
ATOM   1088 C CD  . GLN A 1 138 ? 17.58002  -4.96407  54.11423  1.000 13.17532 ? 138 GLN A CD  1 
ATOM   1089 O OE1 . GLN A 1 138 ? 17.14598  -5.88807  54.82042  1.000 12.37425 ? 138 GLN A OE1 1 
ATOM   1090 N NE2 . GLN A 1 138 ? 18.42452  -4.05432  54.57186  1.000 11.80312 ? 138 GLN A NE2 1 
ATOM   1091 N N   . PHE A 1 139 ? 17.74884  -7.20801  48.53496  1.000 9.43521  ? 139 PHE A N   1 
ATOM   1092 C CA  . PHE A 1 139 ? 18.19830  -8.36346  47.75345  1.000 8.21518  ? 139 PHE A CA  1 
ATOM   1093 C C   . PHE A 1 139 ? 19.71907  -8.36652  47.66301  1.000 12.46096 ? 139 PHE A C   1 
ATOM   1094 O O   . PHE A 1 139 ? 20.32093  -7.35447  47.27778  1.000 7.63260  ? 139 PHE A O   1 
ATOM   1095 C CB  . PHE A 1 139 ? 17.65057  -8.34421  46.31813  1.000 14.39911 ? 139 PHE A CB  1 
ATOM   1096 C CG  . PHE A 1 139 ? 16.23853  -8.83670  46.17945  1.000 23.22441 ? 139 PHE A CG  1 
ATOM   1097 C CD1 . PHE A 1 139 ? 15.94392  -10.18182 46.30771  1.000 36.70013 ? 139 PHE A CD1 1 
ATOM   1098 C CD2 . PHE A 1 139 ? 15.21020  -7.96144  45.87779  1.000 29.82170 ? 139 PHE A CD2 1 
ATOM   1099 C CE1 . PHE A 1 139 ? 14.63583  -10.64194 46.17028  1.000 42.91606 ? 139 PHE A CE1 1 
ATOM   1100 C CE2 . PHE A 1 139 ? 13.89413  -8.41911  45.73261  1.000 29.28968 ? 139 PHE A CE2 1 
ATOM   1101 C CZ  . PHE A 1 139 ? 13.61199  -9.75559  45.88146  1.000 32.83371 ? 139 PHE A CZ  1 
ATOM   1102 N N   . ARG A 1 140 ? 20.33882  -9.49604  48.00153  1.000 10.41236 ? 140 ARG A N   1 
ATOM   1103 C CA  . ARG A 1 140 ? 21.73551  -9.75332  47.65464  1.000 11.61372 ? 140 ARG A CA  1 
ATOM   1104 C C   . ARG A 1 140 ? 21.76919  -10.89351 46.64373  1.000 15.70312 ? 140 ARG A C   1 
ATOM   1105 O O   . ARG A 1 140 ? 21.26776  -11.98863 46.91660  1.000 17.82213 ? 140 ARG A O   1 
ATOM   1106 C CB  . ARG A 1 140 ? 22.58595  -10.09093 48.88647  1.000 18.66123 ? 140 ARG A CB  1 
ATOM   1107 C CG  . ARG A 1 140 ? 23.91639  -10.83330 48.53527  1.000 18.11699 ? 140 ARG A CG  1 
ATOM   1108 C CD  . ARG A 1 140 ? 24.89044  -10.81601 49.69235  1.000 17.06442 ? 140 ARG A CD  1 
ATOM   1109 N NE  . ARG A 1 140 ? 25.44534  -9.48147  49.87170  1.000 13.32389 ? 140 ARG A NE  1 
ATOM   1110 C CZ  . ARG A 1 140 ? 26.48648  -9.19131  50.63186  1.000 18.52863 ? 140 ARG A CZ  1 
ATOM   1111 N NH1 . ARG A 1 140 ? 27.11425  -10.12865 51.33363  1.000 16.93490 ? 140 ARG A NH1 1 
ATOM   1112 N NH2 . ARG A 1 140 ? 26.92257  -7.93362  50.67583  1.000 13.47041 ? 140 ARG A NH2 1 
ATOM   1113 N N   . ILE A 1 141 ? 22.31259  -10.61526 45.46602  1.000 13.86992 ? 141 ILE A N   1 
ATOM   1114 C CA  . ILE A 1 141 ? 22.43949  -11.58553 44.38828  1.000 11.05748 ? 141 ILE A CA  1 
ATOM   1115 C C   . ILE A 1 141 ? 23.86756  -12.09171 44.42799  1.000 18.15069 ? 141 ILE A C   1 
ATOM   1116 O O   . ILE A 1 141 ? 24.80261  -11.28552 44.51471  1.000 12.40098 ? 141 ILE A O   1 
ATOM   1117 C CB  . ILE A 1 141 ? 22.13395  -10.94359 43.02270  1.000 18.06981 ? 141 ILE A CB  1 
ATOM   1118 C CG1 . ILE A 1 141 ? 20.79218  -10.18771 43.05363  1.000 27.85677 ? 141 ILE A CG1 1 
ATOM   1119 C CG2 . ILE A 1 141 ? 22.17686  -11.98519 41.89844  1.000 21.91400 ? 141 ILE A CG2 1 
ATOM   1120 C CD1 . ILE A 1 141 ? 19.65829  -10.96737 43.66480  1.000 36.55272 ? 141 ILE A CD1 1 
ATOM   1121 N N   . ILE A 1 142 ? 24.04631  -13.41386 44.36977  1.000 16.91689 ? 142 ILE A N   1 
ATOM   1122 C CA  . ILE A 1 142 ? 25.36366  -14.02710 44.51926  1.000 23.71293 ? 142 ILE A CA  1 
ATOM   1123 C C   . ILE A 1 142 ? 25.58043  -15.01068 43.37766  1.000 30.37354 ? 142 ILE A C   1 
ATOM   1124 O O   . ILE A 1 142 ? 24.74437  -15.89158 43.14519  1.000 27.50351 ? 142 ILE A O   1 
ATOM   1125 C CB  . ILE A 1 142 ? 25.52108  -14.75532 45.87127  1.000 28.45449 ? 142 ILE A CB  1 
ATOM   1126 C CG1 . ILE A 1 142 ? 25.11428  -13.85375 47.03927  1.000 27.90661 ? 142 ILE A CG1 1 
ATOM   1127 C CG2 . ILE A 1 142 ? 26.95568  -15.24478 46.06102  1.000 21.86325 ? 142 ILE A CG2 1 
ATOM   1128 C CD1 . ILE A 1 142 ? 25.23788  -14.52541 48.40440  1.000 24.08404 ? 142 ILE A CD1 1 
ATOM   1129 N N   . SER A 1 143 ? 26.70274  -14.86021 42.67104  1.000 26.16365 ? 143 SER A N   1 
ATOM   1130 C CA  . SER A 1 143 ? 27.18343  -15.84459 41.70418  1.000 26.74307 ? 143 SER A CA  1 
ATOM   1131 C C   . SER A 1 143 ? 28.52632  -16.34954 42.20533  1.000 25.10485 ? 143 SER A C   1 
ATOM   1132 O O   . SER A 1 143 ? 29.49843  -15.59122 42.24426  1.000 23.96983 ? 143 SER A O   1 
ATOM   1133 C CB  . SER A 1 143 ? 27.33106  -15.25504 40.30577  1.000 27.89616 ? 143 SER A CB  1 
ATOM   1134 O OG  . SER A 1 143 ? 26.35330  -15.77486 39.42431  1.000 38.73084 ? 143 SER A OG  1 
ATOM   1135 N N   . THR A 1 144 ? 28.57598  -17.61611 42.58173  1.000 32.12438 ? 144 THR A N   1 
ATOM   1136 C CA  . THR A 1 144 ? 29.72768  -18.28933 43.15622  1.000 35.72382 ? 144 THR A CA  1 
ATOM   1137 C C   . THR A 1 144 ? 30.58142  -18.93789 42.06828  1.000 39.43297 ? 144 THR A C   1 
ATOM   1138 O O   . THR A 1 144 ? 30.06547  -19.34539 41.02069  1.000 38.05636 ? 144 THR A O   1 
ATOM   1139 C CB  . THR A 1 144 ? 29.27008  -19.35559 44.14350  1.000 47.03928 ? 144 THR A CB  1 
ATOM   1140 O OG1 . THR A 1 144 ? 28.48326  -20.34239 43.45253  1.000 47.42029 ? 144 THR A OG1 1 
ATOM   1141 C CG2 . THR A 1 144 ? 28.44043  -18.71794 45.24849  1.000 44.21656 ? 144 THR A CG2 1 
ATOM   1142 N N   . PRO A 1 145 ? 31.89269  -19.04055 42.29688  1.000 35.72993 ? 145 PRO A N   1 
ATOM   1143 C CA  . PRO A 1 145 ? 32.76412  -19.72554 41.32520  1.000 44.84515 ? 145 PRO A CA  1 
ATOM   1144 C C   . PRO A 1 145 ? 32.41717  -21.20170 41.26723  1.000 43.97383 ? 145 PRO A C   1 
ATOM   1145 O O   . PRO A 1 145 ? 32.45441  -21.89856 42.28365  1.000 51.15111 ? 145 PRO A O   1 
ATOM   1146 C CB  . PRO A 1 145 ? 34.17199  -19.49442 41.88989  1.000 46.24831 ? 145 PRO A CB  1 
ATOM   1147 C CG  . PRO A 1 145 ? 34.00213  -18.48252 43.01002  1.000 42.79685 ? 145 PRO A CG  1 
ATOM   1148 C CD  . PRO A 1 145 ? 32.62315  -18.65078 43.51404  1.000 30.17003 ? 145 PRO A CD  1 
ATOM   1149 N N   . ASP A 1 146 ? 32.07618  -21.68704 40.07906  1.000 48.40225 ? 146 ASP A N   1 
ATOM   1150 C CA  . ASP A 1 146 ? 31.50237  -23.01984 39.97370  1.000 57.24430 ? 146 ASP A CA  1 
ATOM   1151 C C   . ASP A 1 146 ? 31.64975  -23.65541 38.59993  1.000 63.68950 ? 146 ASP A C   1 
ATOM   1152 O O   . ASP A 1 146 ? 31.05744  -24.69993 38.31644  1.000 59.95682 ? 146 ASP A O   1 
ATOM   1153 C CB  . ASP A 1 146 ? 30.00998  -22.95200 40.36381  1.000 48.06547 ? 146 ASP A CB  1 
ATOM   1154 C CG  . ASP A 1 146 ? 29.70670  -23.72261 41.60814  1.000 62.06698 ? 146 ASP A CG  1 
ATOM   1155 O OD1 . ASP A 1 146 ? 30.33785  -23.44212 42.66189  1.000 56.81543 ? 146 ASP A OD1 1 
ATOM   1156 O OD2 . ASP A 1 146 ? 28.83313  -24.60716 41.55856  1.000 70.57898 ? 146 ASP A OD2 1 
ATOM   1157 N N   . PRO A 1 153 ? 17.68198  -16.99611 34.31981  1.000 57.95913 ? 153 PRO A N   1 
ATOM   1158 C CA  . PRO A 1 153 ? 17.27288  -15.58530 34.31588  1.000 58.25759 ? 153 PRO A CA  1 
ATOM   1159 C C   . PRO A 1 153 ? 15.76512  -15.39348 34.17377  1.000 52.18821 ? 153 PRO A C   1 
ATOM   1160 O O   . PRO A 1 153 ? 15.12916  -16.03163 33.33033  1.000 52.05407 ? 153 PRO A O   1 
ATOM   1161 C CB  . PRO A 1 153 ? 18.00567  -15.00556 33.09494  1.000 52.52944 ? 153 PRO A CB  1 
ATOM   1162 C CG  . PRO A 1 153 ? 18.42261  -16.18884 32.27767  1.000 55.07029 ? 153 PRO A CG  1 
ATOM   1163 C CD  . PRO A 1 153 ? 18.66501  -17.28766 33.26356  1.000 52.74760 ? 153 PRO A CD  1 
ATOM   1164 N N   . GLU A 1 154 ? 15.19766  -14.51691 34.99595  1.000 48.86220 ? 154 GLU A N   1 
ATOM   1165 C CA  . GLU A 1 154 ? 13.78551  -14.18226 34.87740  1.000 47.88086 ? 154 GLU A CA  1 
ATOM   1166 C C   . GLU A 1 154 ? 13.56236  -13.26552 33.67550  1.000 45.18455 ? 154 GLU A C   1 
ATOM   1167 O O   . GLU A 1 154 ? 14.35232  -12.35427 33.40684  1.000 36.40792 ? 154 GLU A O   1 
ATOM   1168 C CB  . GLU A 1 154 ? 13.28191  -13.52011 36.16592  1.000 49.25148 ? 154 GLU A CB  1 
ATOM   1169 C CG  . GLU A 1 154 ? 11.81725  -13.08351 36.13079  1.000 40.66963 ? 154 GLU A CG  1 
ATOM   1170 C CD  . GLU A 1 154 ? 11.26910  -12.67828 37.50222  1.000 48.40404 ? 154 GLU A CD  1 
ATOM   1171 O OE1 . GLU A 1 154 ? 12.05721  -12.50451 38.46442  1.000 50.58282 ? 154 GLU A OE1 1 
ATOM   1172 O OE2 . GLU A 1 154 ? 10.03183  -12.53974 37.61800  1.000 48.67497 ? 154 GLU A OE2 1 
ATOM   1173 N N   . GLY A 1 155 ? 12.49228  -13.52785 32.93554  1.000 28.31311 ? 155 GLY A N   1 
ATOM   1174 C CA  . GLY A 1 155 ? 12.14904  -12.71699 31.79653  1.000 26.52166 ? 155 GLY A CA  1 
ATOM   1175 C C   . GLY A 1 155 ? 11.45141  -11.43421 32.19436  1.000 22.68771 ? 155 GLY A C   1 
ATOM   1176 O O   . GLY A 1 155 ? 11.28817  -11.13136 33.38129  1.000 22.96388 ? 155 GLY A O   1 
ATOM   1177 N N   . PRO A 1 156 ? 11.01179  -10.66402 31.19922  1.000 19.36059 ? 156 PRO A N   1 
ATOM   1178 C CA  . PRO A 1 156 ? 10.37325  -9.37774  31.48993  1.000 16.64654 ? 156 PRO A CA  1 
ATOM   1179 C C   . PRO A 1 156 ? 9.14679   -9.58749  32.35897  1.000 17.11625 ? 156 PRO A C   1 
ATOM   1180 O O   . PRO A 1 156 ? 8.39348   -10.53854 32.17123  1.000 20.34177 ? 156 PRO A O   1 
ATOM   1181 C CB  . PRO A 1 156 ? 10.00834  -8.84225  30.10056  1.000 15.43408 ? 156 PRO A CB  1 
ATOM   1182 C CG  . PRO A 1 156 ? 10.93097  -9.61449  29.13962  1.000 20.02614 ? 156 PRO A CG  1 
ATOM   1183 C CD  . PRO A 1 156 ? 10.98620  -10.97749 29.75912  1.000 16.48161 ? 156 PRO A CD  1 
ATOM   1184 N N   . HIS A 1 157 ? 8.97875   -8.72253  33.35158  1.000 14.24665 ? 157 HIS A N   1 
ATOM   1185 C CA  . HIS A 1 157 ? 7.88699   -8.89318  34.30918  1.000 15.43669 ? 157 HIS A CA  1 
ATOM   1186 C C   . HIS A 1 157 ? 7.58066   -7.54404  34.93437  1.000 17.57877 ? 157 HIS A C   1 
ATOM   1187 O O   . HIS A 1 157 ? 8.29680   -6.56425  34.71680  1.000 14.32428 ? 157 HIS A O   1 
ATOM   1188 C CB  . HIS A 1 157 ? 8.23588   -9.90987  35.39997  1.000 20.18315 ? 157 HIS A CB  1 
ATOM   1189 C CG  . HIS A 1 157 ? 9.36521   -9.48281  36.28892  1.000 19.41560 ? 157 HIS A CG  1 
ATOM   1190 N ND1 . HIS A 1 157 ? 10.68664  -9.73410  35.98813  1.000 22.90139 ? 157 HIS A ND1 1 
ATOM   1191 C CD2 . HIS A 1 157 ? 9.37080   -8.81611  37.46723  1.000 21.01897 ? 157 HIS A CD2 1 
ATOM   1192 C CE1 . HIS A 1 157 ? 11.45780  -9.24341  36.94105  1.000 20.51232 ? 157 HIS A CE1 1 
ATOM   1193 N NE2 . HIS A 1 157 ? 10.68423  -8.68079  37.85112  1.000 25.51003 ? 157 HIS A NE2 1 
ATOM   1194 N N   . ARG A 1 158 ? 6.49662   -7.50206  35.70898  1.000 15.97861 ? 158 ARG A N   1 
ATOM   1195 C CA  . ARG A 1 158 ? 6.18348   -6.35042  36.54256  1.000 12.73655 ? 158 ARG A CA  1 
ATOM   1196 C C   . ARG A 1 158 ? 6.11370   -6.81657  37.98389  1.000 13.91512 ? 158 ARG A C   1 
ATOM   1197 O O   . ARG A 1 158 ? 6.07537   -8.01827  38.26498  1.000 21.20206 ? 158 ARG A O   1 
ATOM   1198 C CB  . ARG A 1 158 ? 4.87361   -5.66705  36.11452  1.000 16.11866 ? 158 ARG A CB  1 
ATOM   1199 C CG  . ARG A 1 158 ? 3.64037   -6.54888  36.28507  1.000 17.91489 ? 158 ARG A CG  1 
ATOM   1200 C CD  . ARG A 1 158 ? 2.35916   -5.77774  36.03428  1.000 18.20709 ? 158 ARG A CD  1 
ATOM   1201 N NE  . ARG A 1 158 ? 2.26984   -4.56390  36.84432  1.000 18.14539 ? 158 ARG A NE  1 
ATOM   1202 C CZ  . ARG A 1 158 ? 1.20637   -3.77019  36.87339  1.000 22.47383 ? 158 ARG A CZ  1 
ATOM   1203 N NH1 . ARG A 1 158 ? 0.12546   -4.03440  36.15277  1.000 20.04572 ? 158 ARG A NH1 1 
ATOM   1204 N NH2 . ARG A 1 158 ? 1.23197   -2.67729  37.62873  1.000 16.77250 ? 158 ARG A NH2 1 
ATOM   1205 N N   . ASP A 1 159 ? 6.15087   -5.85123  38.90728  1.000 13.94590 ? 159 ASP A N   1 
ATOM   1206 C CA  . ASP A 1 159 ? 6.10019   -6.13050  40.33812  1.000 10.15083 ? 159 ASP A CA  1 
ATOM   1207 C C   . ASP A 1 159 ? 4.68566   -6.06290  40.89443  1.000 13.29170 ? 159 ASP A C   1 
ATOM   1208 O O   . ASP A 1 159 ? 4.49006   -6.30390  42.08905  1.000 16.07246 ? 159 ASP A O   1 
ATOM   1209 C CB  . ASP A 1 159 ? 7.01450   -5.14684  41.09075  1.000 10.76787 ? 159 ASP A CB  1 
ATOM   1210 C CG  . ASP A 1 159 ? 8.49764   -5.42121  40.84848  1.000 18.01132 ? 159 ASP A CG  1 
ATOM   1211 O OD1 . ASP A 1 159 ? 8.82028   -6.32219  40.05134  1.000 19.71751 ? 159 ASP A OD1 1 
ATOM   1212 O OD2 . ASP A 1 159 ? 9.34614   -4.76274  41.47539  1.000 19.37850 ? 159 ASP A OD2 1 
ATOM   1213 N N   . GLU A 1 160 ? 3.70811   -5.72770  40.05289  1.000 17.00582 ? 160 GLU A N   1 
ATOM   1214 C CA  . GLU A 1 160 ? 2.29694   -5.61271  40.43205  1.000 15.37713 ? 160 GLU A CA  1 
ATOM   1215 C C   . GLU A 1 160 ? 2.08559   -4.50915  41.47070  1.000 14.03371 ? 160 GLU A C   1 
ATOM   1216 O O   . GLU A 1 160 ? 1.38335   -4.67551  42.46488  1.000 18.70304 ? 160 GLU A O   1 
ATOM   1217 C CB  . GLU A 1 160 ? 1.74356   -6.96572  40.91159  1.000 17.81385 ? 160 GLU A CB  1 
ATOM   1218 C CG  . GLU A 1 160 ? 1.78254   -8.08193  39.85122  1.000 18.79250 ? 160 GLU A CG  1 
ATOM   1219 C CD  . GLU A 1 160 ? 0.97455   -7.77954  38.58653  1.000 34.94037 ? 160 GLU A CD  1 
ATOM   1220 O OE1 . GLU A 1 160 ? 0.21604   -6.78121  38.56200  1.000 32.04197 ? 160 GLU A OE1 1 
ATOM   1221 O OE2 . GLU A 1 160 ? 1.10341   -8.55032  37.60143  1.000 31.98219 ? 160 GLU A OE2 1 
ATOM   1222 N N   . VAL A 1 161 ? 2.69554   -3.35963  41.21828  1.000 14.14420 ? 161 VAL A N   1 
ATOM   1223 C CA  . VAL A 1 161 ? 2.54853   -2.16854  42.02334  1.000 10.32281 ? 161 VAL A CA  1 
ATOM   1224 C C   . VAL A 1 161 ? 2.27545   -1.01620  41.07040  1.000 14.90352 ? 161 VAL A C   1 
ATOM   1225 O O   . VAL A 1 161 ? 2.16187   -1.20971  39.86282  1.000 15.26313 ? 161 VAL A O   1 
ATOM   1226 C CB  . VAL A 1 161 ? 3.80329   -1.88926  42.89277  1.000 8.30439  ? 161 VAL A CB  1 
ATOM   1227 C CG1 . VAL A 1 161 ? 3.97825   -2.96439  43.90186  1.000 10.30550 ? 161 VAL A CG1 1 
ATOM   1228 C CG2 . VAL A 1 161 ? 5.04745   -1.79302  42.01039  1.000 12.44151 ? 161 VAL A CG2 1 
ATOM   1229 N N   . ASP A 1 162 ? 2.20171   0.19966   41.61393  1.000 15.02481 ? 162 ASP A N   1 
ATOM   1230 C CA  . ASP A 1 162 ? 2.08875   1.37806   40.76022  1.000 14.30799 ? 162 ASP A CA  1 
ATOM   1231 C C   . ASP A 1 162 ? 3.44622   1.94192   40.35393  1.000 13.01539 ? 162 ASP A C   1 
ATOM   1232 O O   . ASP A 1 162 ? 3.67869   2.22110   39.17196  1.000 9.88167  ? 162 ASP A O   1 
ATOM   1233 C CB  . ASP A 1 162 ? 1.28257   2.46342   41.47511  1.000 12.31192 ? 162 ASP A CB  1 
ATOM   1234 C CG  . ASP A 1 162 ? -0.19987  2.14369   41.50606  1.000 22.99015 ? 162 ASP A CG  1 
ATOM   1235 O OD1 . ASP A 1 162 ? -0.77529  1.94261   40.40751  1.000 22.87083 ? 162 ASP A OD1 1 
ATOM   1236 O OD2 . ASP A 1 162 ? -0.77151  2.04782   42.61608  1.000 16.79765 ? 162 ASP A OD2 1 
ATOM   1237 N N   . PHE A 1 163 ? 4.34879   2.14210   41.32045  1.000 9.28955  ? 163 PHE A N   1 
ATOM   1238 C CA  . PHE A 1 163 ? 5.64248   2.70981   41.00468  1.000 9.38051  ? 163 PHE A CA  1 
ATOM   1239 C C   . PHE A 1 163 ? 6.73891   1.94767   41.73667  1.000 8.71187  ? 163 PHE A C   1 
ATOM   1240 O O   . PHE A 1 163 ? 6.52578   1.43584   42.83035  1.000 9.25269  ? 163 PHE A O   1 
ATOM   1241 C CB  . PHE A 1 163 ? 5.67687   4.19912   41.36336  1.000 11.33839 ? 163 PHE A CB  1 
ATOM   1242 C CG  . PHE A 1 163 ? 4.70036   5.02736   40.58043  1.000 14.78091 ? 163 PHE A CG  1 
ATOM   1243 C CD1 . PHE A 1 163 ? 5.02088   5.47160   39.29957  1.000 12.70768 ? 163 PHE A CD1 1 
ATOM   1244 C CD2 . PHE A 1 163 ? 3.46436   5.35667   41.12074  1.000 12.92821 ? 163 PHE A CD2 1 
ATOM   1245 C CE1 . PHE A 1 163 ? 4.11313   6.25023   38.55842  1.000 17.98498 ? 163 PHE A CE1 1 
ATOM   1246 C CE2 . PHE A 1 163 ? 2.55369   6.13514   40.39314  1.000 19.58789 ? 163 PHE A CE2 1 
ATOM   1247 C CZ  . PHE A 1 163 ? 2.88081   6.57840   39.11054  1.000 19.71066 ? 163 PHE A CZ  1 
ATOM   1248 N N   . GLY A 1 164 ? 7.90794   1.83904   41.09952  1.000 10.09684 ? 164 GLY A N   1 
ATOM   1249 C CA  . GLY A 1 164 ? 9.01045   1.15867   41.77272  1.000 4.20565  ? 164 GLY A CA  1 
ATOM   1250 C C   . GLY A 1 164 ? 10.26731  1.98951   41.85420  1.000 4.54235  ? 164 GLY A C   1 
ATOM   1251 O O   . GLY A 1 164 ? 10.45185  2.91615   41.06575  1.000 7.34437  ? 164 GLY A O   1 
ATOM   1252 N N   . VAL A 1 165 ? 11.17597  1.66257   42.77733  1.000 7.19065  ? 165 VAL A N   1 
ATOM   1253 C CA  . VAL A 1 165 ? 12.48622  2.29896   42.79148  1.000 8.81371  ? 165 VAL A CA  1 
ATOM   1254 C C   . VAL A 1 165 ? 13.52603  1.23585   43.13601  1.000 7.69638  ? 165 VAL A C   1 
ATOM   1255 O O   . VAL A 1 165 ? 13.27459  0.33284   43.92955  1.000 4.70117  ? 165 VAL A O   1 
ATOM   1256 C CB  . VAL A 1 165 ? 12.53303  3.48563   43.77616  1.000 9.32598  ? 165 VAL A CB  1 
ATOM   1257 C CG1 . VAL A 1 165 ? 12.19794  3.04187   45.19302  1.000 5.15027  ? 165 VAL A CG1 1 
ATOM   1258 C CG2 . VAL A 1 165 ? 13.86286  4.18529   43.73609  1.000 6.95781  ? 165 VAL A CG2 1 
ATOM   1259 N N   . ILE A 1 166 ? 14.69598  1.33269   42.53361  1.000 6.21167  ? 166 ILE A N   1 
ATOM   1260 C CA  . ILE A 1 166 ? 15.77203  0.42761   42.89683  1.000 4.14468  ? 166 ILE A CA  1 
ATOM   1261 C C   . ILE A 1 166 ? 16.99964  1.27128   43.15331  1.000 8.01422  ? 166 ILE A C   1 
ATOM   1262 O O   . ILE A 1 166 ? 17.29438  2.18749   42.37911  1.000 5.19314  ? 166 ILE A O   1 
ATOM   1263 C CB  . ILE A 1 166 ? 16.02201  -0.64036  41.81305  1.000 7.15957  ? 166 ILE A CB  1 
ATOM   1264 C CG1 . ILE A 1 166 ? 17.29502  -1.44025  42.11056  1.000 7.44543  ? 166 ILE A CG1 1 
ATOM   1265 C CG2 . ILE A 1 166 ? 16.09410  -0.00849  40.42876  1.000 8.75353  ? 166 ILE A CG2 1 
ATOM   1266 C CD1 . ILE A 1 166 ? 17.47175  -2.57938  41.13445  1.000 11.52756 ? 166 ILE A CD1 1 
ATOM   1267 N N   . HIS A 1 167 ? 17.70069  0.99393   44.25791  1.000 5.31271  ? 167 HIS A N   1 
ATOM   1268 C CA  . HIS A 1 167 ? 18.97118  1.65063   44.55028  1.000 4.00041  ? 167 HIS A CA  1 
ATOM   1269 C C   . HIS A 1 167 ? 20.03597  0.57122   44.65011  1.000 9.48235  ? 167 HIS A C   1 
ATOM   1270 O O   . HIS A 1 167 ? 19.84444  -0.40093  45.38308  1.000 5.39879  ? 167 HIS A O   1 
ATOM   1271 C CB  . HIS A 1 167 ? 18.93221  2.39837   45.88796  1.000 5.71863  ? 167 HIS A CB  1 
ATOM   1272 C CG  . HIS A 1 167 ? 17.77756  3.33654   46.05647  1.000 5.73257  ? 167 HIS A CG  1 
ATOM   1273 N ND1 . HIS A 1 167 ? 17.72955  4.57835   45.45239  1.000 7.66922  ? 167 HIS A ND1 1 
ATOM   1274 C CD2 . HIS A 1 167 ? 16.68099  3.26761   46.84987  1.000 8.81933  ? 167 HIS A CD2 1 
ATOM   1275 C CE1 . HIS A 1 167 ? 16.63433  5.21061   45.83246  1.000 7.68424  ? 167 HIS A CE1 1 
ATOM   1276 N NE2 . HIS A 1 167 ? 15.98289  4.43994   46.69059  1.000 9.19629  ? 167 HIS A NE2 1 
ATOM   1277 N N   . LEU A 1 168 ? 21.17756  0.78584   43.99458  1.000 6.21909  ? 168 LEU A N   1 
ATOM   1278 C CA  . LEU A 1 168 ? 22.31457  -0.11855  44.09860  1.000 7.25947  ? 168 LEU A CA  1 
ATOM   1279 C C   . LEU A 1 168 ? 23.01635  0.15751   45.41976  1.000 5.37937  ? 168 LEU A C   1 
ATOM   1280 O O   . LEU A 1 168 ? 23.53991  1.25559   45.63498  1.000 8.98579  ? 168 LEU A O   1 
ATOM   1281 C CB  . LEU A 1 168 ? 23.26860  0.08014   42.92463  1.000 7.93030  ? 168 LEU A CB  1 
ATOM   1282 C CG  . LEU A 1 168 ? 24.49128  -0.84092  42.96206  1.000 9.37973  ? 168 LEU A CG  1 
ATOM   1283 C CD1 . LEU A 1 168 ? 24.06389  -2.26311  42.65335  1.000 9.60381  ? 168 LEU A CD1 1 
ATOM   1284 C CD2 . LEU A 1 168 ? 25.57772  -0.36359  42.01778  1.000 9.64316  ? 168 LEU A CD2 1 
ATOM   1285 N N   . MET A 1 169 ? 23.01760  -0.82096  46.30998  1.000 6.29103  ? 169 MET A N   1 
ATOM   1286 C CA  . MET A 1 169 ? 23.78193  -0.65607  47.54270  1.000 6.29776  ? 169 MET A CA  1 
ATOM   1287 C C   . MET A 1 169 ? 25.23246  -1.03617  47.35692  1.000 14.20894 ? 169 MET A C   1 
ATOM   1288 O O   . MET A 1 169 ? 26.09230  -0.56496  48.10418  1.000 13.01102 ? 169 MET A O   1 
ATOM   1289 C CB  . MET A 1 169 ? 23.20084  -1.51576  48.66501  1.000 3.88017  ? 169 MET A CB  1 
ATOM   1290 C CG  . MET A 1 169 ? 21.84115  -1.05863  49.14617  1.000 10.13138 ? 169 MET A CG  1 
ATOM   1291 S SD  . MET A 1 169 ? 21.96235  0.57979   49.89547  1.000 23.54595 ? 169 MET A SD  1 
ATOM   1292 C CE  . MET A 1 169 ? 21.12980  1.47061   48.66489  1.000 4.00426  ? 169 MET A CE  1 
ATOM   1293 N N   . GLY A 1 170 ? 25.51277  -1.92100  46.41950  1.000 13.71922 ? 170 GLY A N   1 
ATOM   1294 C CA  . GLY A 1 170 ? 26.86586  -2.40826  46.29516  1.000 14.32316 ? 170 GLY A CA  1 
ATOM   1295 C C   . GLY A 1 170 ? 27.02219  -3.39600  45.17605  1.000 13.62060 ? 170 GLY A C   1 
ATOM   1296 O O   . GLY A 1 170 ? 26.07647  -4.07305  44.77864  1.000 10.67117 ? 170 GLY A O   1 
ATOM   1297 N N   . ARG A 1 171 ? 28.23722  -3.47701  44.66081  1.000 10.52743 ? 171 ARG A N   1 
ATOM   1298 C CA  . ARG A 1 171 ? 28.55812  -4.31914  43.52574  1.000 15.06538 ? 171 ARG A CA  1 
ATOM   1299 C C   . ARG A 1 171 ? 29.98530  -4.77202  43.76755  1.000 22.70274 ? 171 ARG A C   1 
ATOM   1300 O O   . ARG A 1 171 ? 30.86310  -3.92159  43.95742  1.000 21.24008 ? 171 ARG A O   1 
ATOM   1301 C CB  . ARG A 1 171 ? 28.44482  -3.52918  42.22138  1.000 26.03955 ? 171 ARG A CB  1 
ATOM   1302 C CG  . ARG A 1 171 ? 28.00427  -4.31055  41.03905  1.000 33.78513 ? 171 ARG A CG  1 
ATOM   1303 C CD  . ARG A 1 171 ? 27.57700  -3.35785  39.93355  1.000 31.77006 ? 171 ARG A CD  1 
ATOM   1304 N NE  . ARG A 1 171 ? 27.51621  -4.05124  38.65605  1.000 32.45391 ? 171 ARG A NE  1 
ATOM   1305 C CZ  . ARG A 1 171 ? 28.52804  -4.09574  37.80068  1.000 35.79088 ? 171 ARG A CZ  1 
ATOM   1306 N NH1 . ARG A 1 171 ? 29.66247  -3.45857  38.04231  1.000 39.97039 ? 171 ARG A NH1 1 
ATOM   1307 N NH2 . ARG A 1 171 ? 28.40144  -4.80077  36.67987  1.000 35.02647 ? 171 ARG A NH2 1 
ATOM   1308 N N   . PHE A 1 172 ? 30.20732  -6.08986  43.81606  1.000 15.26707 ? 172 PHE A N   1 
ATOM   1309 C CA  . PHE A 1 172 ? 31.49190  -6.64631  44.23475  1.000 18.16446 ? 172 PHE A CA  1 
ATOM   1310 C C   . PHE A 1 172 ? 31.92198  -7.71199  43.24146  1.000 13.77593 ? 172 PHE A C   1 
ATOM   1311 O O   . PHE A 1 172 ? 31.26646  -8.75498  43.13032  1.000 14.25588 ? 172 PHE A O   1 
ATOM   1312 C CB  . PHE A 1 172 ? 31.39612  -7.22690  45.65495  1.000 18.29569 ? 172 PHE A CB  1 
ATOM   1313 C CG  . PHE A 1 172 ? 30.78717  -6.27634  46.66022  1.000 31.03598 ? 172 PHE A CG  1 
ATOM   1314 C CD1 . PHE A 1 172 ? 31.56498  -5.31910  47.28754  1.000 27.50042 ? 172 PHE A CD1 1 
ATOM   1315 C CD2 . PHE A 1 172 ? 29.42570  -6.34142  46.97267  1.000 24.97530 ? 172 PHE A CD2 1 
ATOM   1316 C CE1 . PHE A 1 172 ? 31.01315  -4.44705  48.20917  1.000 33.60733 ? 172 PHE A CE1 1 
ATOM   1317 C CE2 . PHE A 1 172 ? 28.86585  -5.47562  47.89458  1.000 20.40415 ? 172 PHE A CE2 1 
ATOM   1318 C CZ  . PHE A 1 172 ? 29.66020  -4.51987  48.50948  1.000 21.37200 ? 172 PHE A CZ  1 
ATOM   1319 N N   . ASN A 1 173 ? 33.00458  -7.43731  42.49842  1.000 16.11485 ? 173 ASN A N   1 
ATOM   1320 C CA  . ASN A 1 173 ? 33.57279  -8.40854  41.55788  1.000 17.44977 ? 173 ASN A CA  1 
ATOM   1321 C C   . ASN A 1 173 ? 32.53688  -8.85773  40.53063  1.000 20.72598 ? 173 ASN A C   1 
ATOM   1322 O O   . ASN A 1 173 ? 32.50687  -10.01700 40.10250  1.000 14.45077 ? 173 ASN A O   1 
ATOM   1323 C CB  . ASN A 1 173 ? 34.16256  -9.61792  42.30556  1.000 23.07822 ? 173 ASN A CB  1 
ATOM   1324 C CG  . ASN A 1 173 ? 34.86545  -10.61383 41.37190  1.000 16.85969 ? 173 ASN A CG  1 
ATOM   1325 O OD1 . ASN A 1 173 ? 35.59087  -10.22312 40.46879  1.000 19.00136 ? 173 ASN A OD1 1 
ATOM   1326 N ND2 . ASN A 1 173 ? 34.58584  -11.88942 41.55362  1.000 19.08861 ? 173 ASN A ND2 1 
ATOM   1327 N N   . ALA A 1 174 ? 31.66109  -7.94458  40.12031  1.000 17.25427 ? 174 ALA A N   1 
ATOM   1328 C CA  . ALA A 1 174 ? 30.49301  -8.30233  39.33549  1.000 11.52985 ? 174 ALA A CA  1 
ATOM   1329 C C   . ALA A 1 174 ? 30.54244  -7.65234  37.96122  1.000 23.03334 ? 174 ALA A C   1 
ATOM   1330 O O   . ALA A 1 174 ? 30.79276  -6.44860  37.83824  1.000 22.80208 ? 174 ALA A O   1 
ATOM   1331 C CB  . ALA A 1 174 ? 29.20977  -7.89051  40.06121  1.000 21.76031 ? 174 ALA A CB  1 
ATOM   1332 N N   . ALA A 1 175 ? 30.30805  -8.45188  36.93848  1.000 12.94847 ? 175 ALA A N   1 
ATOM   1333 C CA  . ALA A 1 175 ? 30.01008  -7.95545  35.61414  1.000 20.13050 ? 175 ALA A CA  1 
ATOM   1334 C C   . ALA A 1 175 ? 28.60882  -8.42464  35.25349  1.000 17.80617 ? 175 ALA A C   1 
ATOM   1335 O O   . ALA A 1 175 ? 28.01516  -9.24432  35.95199  1.000 21.89124 ? 175 ALA A O   1 
ATOM   1336 C CB  . ALA A 1 175 ? 31.03609  -8.44348  34.59294  1.000 25.60018 ? 175 ALA A CB  1 
ATOM   1337 N N   . GLY A 1 176 ? 28.07812  -7.90871  34.14851  1.000 16.64895 ? 176 GLY A N   1 
ATOM   1338 C CA  . GLY A 1 176 ? 26.69831  -8.20997  33.83650  1.000 21.34622 ? 176 GLY A CA  1 
ATOM   1339 C C   . GLY A 1 176 ? 25.76330  -7.44708  34.75804  1.000 12.49137 ? 176 GLY A C   1 
ATOM   1340 O O   . GLY A 1 176 ? 26.09563  -6.38717  35.28801  1.000 13.16375 ? 176 GLY A O   1 
ATOM   1341 N N   . GLY A 1 177 ? 24.58566  -8.01865  34.98724  1.000 17.16409 ? 177 GLY A N   1 
ATOM   1342 C CA  . GLY A 1 177 ? 23.64025  -7.33892  35.84761  1.000 10.91705 ? 177 GLY A CA  1 
ATOM   1343 C C   . GLY A 1 177 ? 23.00490  -6.11819  35.22076  1.000 10.63662 ? 177 GLY A C   1 
ATOM   1344 O O   . GLY A 1 177 ? 22.48292  -5.27249  35.93775  1.000 10.22467 ? 177 GLY A O   1 
ATOM   1345 N N   . GLU A 1 178 ? 23.07051  -5.98452  33.89780  1.000 11.99113 ? 178 GLU A N   1 
ATOM   1346 C CA  . GLU A 1 178 ? 22.43191  -4.85247  33.23488  1.000 14.07763 ? 178 GLU A CA  1 
ATOM   1347 C C   . GLU A 1 178 ? 20.91698  -4.90204  33.44000  1.000 9.66213  ? 178 GLU A C   1 
ATOM   1348 O O   . GLU A 1 178 ? 20.30637  -5.97279  33.39227  1.000 9.71448  ? 178 GLU A O   1 
ATOM   1349 C CB  . GLU A 1 178 ? 22.76087  -4.86123  31.73605  1.000 11.93178 ? 178 GLU A CB  1 
ATOM   1350 C CG  . GLU A 1 178 ? 24.25394  -4.74385  31.42167  1.000 16.75401 ? 178 GLU A CG  1 
ATOM   1351 C CD  . GLU A 1 178 ? 24.95428  -6.09168  31.33877  1.000 18.87886 ? 178 GLU A CD  1 
ATOM   1352 O OE1 . GLU A 1 178 ? 24.38912  -7.08473  31.81736  1.000 22.69556 ? 178 GLU A OE1 1 
ATOM   1353 O OE2 . GLU A 1 178 ? 26.07578  -6.16630  30.79187  1.000 24.34990 ? 178 GLU A OE2 1 
ATOM   1354 N N   . SER A 1 179 ? 20.31949  -3.73807  33.68541  1.000 13.01141 ? 179 SER A N   1 
ATOM   1355 C CA  . SER A 1 179 ? 18.87360  -3.62829  33.86487  1.000 10.44010 ? 179 SER A CA  1 
ATOM   1356 C C   . SER A 1 179 ? 18.22951  -3.39792  32.51419  1.000 10.70032 ? 179 SER A C   1 
ATOM   1357 O O   . SER A 1 179 ? 18.75774  -2.64680  31.68462  1.000 9.14379  ? 179 SER A O   1 
ATOM   1358 C CB  . SER A 1 179 ? 18.50732  -2.48139  34.81063  1.000 10.49674 ? 179 SER A CB  1 
ATOM   1359 O OG  . SER A 1 179 ? 19.21598  -2.55772  36.04166  1.000 10.71944 ? 179 SER A OG  1 
ATOM   1360 N N   . GLN A 1 180 ? 17.09585  -4.05423  32.28960  1.000 11.47582 ? 180 GLN A N   1 
ATOM   1361 C CA  . GLN A 1 180 ? 16.42883  -4.01806  30.99601  1.000 9.63767  ? 180 GLN A CA  1 
ATOM   1362 C C   . GLN A 1 180 ? 14.99061  -3.55341  31.16591  1.000 8.32762  ? 180 GLN A C   1 
ATOM   1363 O O   . GLN A 1 180 ? 14.30582  -3.94940  32.11241  1.000 6.73247  ? 180 GLN A O   1 
ATOM   1364 C CB  . GLN A 1 180 ? 16.47824  -5.38294  30.32074  1.000 12.26583 ? 180 GLN A CB  1 
ATOM   1365 C CG  . GLN A 1 180 ? 17.91117  -5.90410  30.22893  1.000 14.92194 ? 180 GLN A CG  1 
ATOM   1366 C CD  . GLN A 1 180 ? 18.06538  -7.10530  29.33534  1.000 26.04825 ? 180 GLN A CD  1 
ATOM   1367 O OE1 . GLN A 1 180 ? 17.46985  -8.15316  29.58014  1.000 35.29814 ? 180 GLN A OE1 1 
ATOM   1368 N NE2 . GLN A 1 180 ? 18.88685  -6.96729  28.29285  1.000 23.37024 ? 180 GLN A NE2 1 
ATOM   1369 N N   . VAL A 1 181 ? 14.57082  -2.67416  30.26003  1.000 9.01234  ? 181 VAL A N   1 
ATOM   1370 C CA  . VAL A 1 181 ? 13.22459  -2.12316  30.21643  1.000 10.00079 ? 181 VAL A CA  1 
ATOM   1371 C C   . VAL A 1 181 ? 12.56760  -2.64101  28.94304  1.000 14.39641 ? 181 VAL A C   1 
ATOM   1372 O O   . VAL A 1 181 ? 13.15721  -2.55404  27.86014  1.000 12.62305 ? 181 VAL A O   1 
ATOM   1373 C CB  . VAL A 1 181 ? 13.25720  -0.58653  30.23069  1.000 15.26207 ? 181 VAL A CB  1 
ATOM   1374 C CG1 . VAL A 1 181 ? 11.84632  0.00598   30.09383  1.000 12.01365 ? 181 VAL A CG1 1 
ATOM   1375 C CG2 . VAL A 1 181 ? 13.96263  -0.07238  31.49289  1.000 7.72637  ? 181 VAL A CG2 1 
ATOM   1376 N N   . TYR A 1 182 ? 11.36617  -3.19900  29.07844  1.000 14.32151 ? 182 TYR A N   1 
ATOM   1377 C CA  . TYR A 1 182 ? 10.60808  -3.72249  27.94767  1.000 16.51443 ? 182 TYR A CA  1 
ATOM   1378 C C   . TYR A 1 182 ? 9.27001   -3.00233  27.81217  1.000 19.30245 ? 182 TYR A C   1 
ATOM   1379 O O   . TYR A 1 182 ? 8.72545   -2.48695  28.79695  1.000 13.21346 ? 182 TYR A O   1 
ATOM   1380 C CB  . TYR A 1 182 ? 10.35844  -5.23375  28.10922  1.000 13.75106 ? 182 TYR A CB  1 
ATOM   1381 C CG  . TYR A 1 182 ? 11.60348  -6.09396  28.08442  1.000 20.86806 ? 182 TYR A CG  1 
ATOM   1382 C CD1 . TYR A 1 182 ? 12.36905  -6.28707  29.24883  1.000 12.00167 ? 182 TYR A CD1 1 
ATOM   1383 C CD2 . TYR A 1 182 ? 11.99161  -6.76274  26.92118  1.000 17.44179 ? 182 TYR A CD2 1 
ATOM   1384 C CE1 . TYR A 1 182 ? 13.49307  -7.08234  29.23263  1.000 17.04384 ? 182 TYR A CE1 1 
ATOM   1385 C CE2 . TYR A 1 182 ? 13.12321  -7.57579  26.90328  1.000 21.21651 ? 182 TYR A CE2 1 
ATOM   1386 C CZ  . TYR A 1 182 ? 13.86957  -7.72469  28.06385  1.000 22.87518 ? 182 TYR A CZ  1 
ATOM   1387 O OH  . TYR A 1 182 ? 14.99573  -8.51480  28.07170  1.000 28.47111 ? 182 TYR A OH  1 
ATOM   1388 N N   . SER A 1 183 ? 8.74462   -2.96973  26.58124  1.000 24.14315 ? 183 SER A N   1 
ATOM   1389 C CA  . SER A 1 183 ? 7.36950   -2.55571  26.37043  1.000 17.15934 ? 183 SER A CA  1 
ATOM   1390 C C   . SER A 1 183 ? 6.43109   -3.63488  26.88479  1.000 19.36088 ? 183 SER A C   1 
ATOM   1391 O O   . SER A 1 183 ? 6.83674   -4.77974  27.12890  1.000 17.07494 ? 183 SER A O   1 
ATOM   1392 C CB  . SER A 1 183 ? 7.11176   -2.32023  24.88856  1.000 24.45084 ? 183 SER A CB  1 
ATOM   1393 O OG  . SER A 1 183 ? 7.20661   -3.54854  24.19743  1.000 25.43536 ? 183 SER A OG  1 
ATOM   1394 N N   . LEU A 1 184 ? 5.15084   -3.25858  27.04416  1.000 19.98810 ? 184 LEU A N   1 
ATOM   1395 C CA  . LEU A 1 184 ? 4.10177   -4.21824  27.37541  1.000 28.68787 ? 184 LEU A CA  1 
ATOM   1396 C C   . LEU A 1 184 ? 4.03285   -5.34202  26.37012  1.000 22.63982 ? 184 LEU A C   1 
ATOM   1397 O O   . LEU A 1 184 ? 3.51796   -6.42110  26.68615  1.000 36.03622 ? 184 LEU A O   1 
ATOM   1398 C CB  . LEU A 1 184 ? 2.73648   -3.51343  27.43715  1.000 29.63363 ? 184 LEU A CB  1 
ATOM   1399 C CG  . LEU A 1 184 ? 2.77564   -2.38782  28.46594  1.000 39.25792 ? 184 LEU A CG  1 
ATOM   1400 C CD1 . LEU A 1 184 ? 1.41264   -1.75458  28.72820  1.000 34.17214 ? 184 LEU A CD1 1 
ATOM   1401 C CD2 . LEU A 1 184 ? 3.40122   -2.90483  29.76071  1.000 19.68597 ? 184 LEU A CD2 1 
ATOM   1402 N N   . GLU A 1 185 ? 4.54947   -5.10741  25.17695  1.000 25.69511 ? 185 GLU A N   1 
ATOM   1403 C CA  . GLU A 1 185 ? 4.62619   -6.10067  24.12321  1.000 35.14470 ? 185 GLU A CA  1 
ATOM   1404 C C   . GLU A 1 185 ? 5.94540   -6.86650  24.13316  1.000 41.99841 ? 185 GLU A C   1 
ATOM   1405 O O   . GLU A 1 185 ? 6.20709   -7.63208  23.19840  1.000 29.93276 ? 185 GLU A O   1 
ATOM   1406 C CB  . GLU A 1 185 ? 4.40916   -5.41563  22.77585  1.000 32.29719 ? 185 GLU A CB  1 
ATOM   1407 C CG  . GLU A 1 185 ? 3.31398   -4.36423  22.84836  1.000 45.24510 ? 185 GLU A CG  1 
ATOM   1408 C CD  . GLU A 1 185 ? 2.49079   -4.26927  21.58415  1.000 66.92429 ? 185 GLU A CD  1 
ATOM   1409 O OE1 . GLU A 1 185 ? 2.96367   -3.63969  20.61047  1.000 75.14184 ? 185 GLU A OE1 1 
ATOM   1410 O OE2 . GLU A 1 185 ? 1.37710   -4.83984  21.56518  1.000 62.91524 ? 185 GLU A OE2 1 
ATOM   1411 N N   . ARG A 1 186 ? 6.77954   -6.66373  25.16236  1.000 30.19036 ? 186 ARG A N   1 
ATOM   1412 C CA  . ARG A 1 186 ? 8.00319   -7.43841  25.39787  1.000 21.20281 ? 186 ARG A CA  1 
ATOM   1413 C C   . ARG A 1 186 ? 9.07687   -7.18219  24.34841  1.000 21.08146 ? 186 ARG A C   1 
ATOM   1414 O O   . ARG A 1 186 ? 9.87089   -8.07067  24.03935  1.000 28.50805 ? 186 ARG A O   1 
ATOM   1415 C CB  . ARG A 1 186 ? 7.70211   -8.93734  25.51292  1.000 22.44262 ? 186 ARG A CB  1 
ATOM   1416 C CG  . ARG A 1 186 ? 6.90997   -9.25630  26.77882  1.000 27.43689 ? 186 ARG A CG  1 
ATOM   1417 C CD  . ARG A 1 186 ? 6.64869   -10.74483 26.99577  1.000 38.53442 ? 186 ARG A CD  1 
ATOM   1418 N NE  . ARG A 1 186 ? 6.29733   -10.99860 28.39001  1.000 45.02407 ? 186 ARG A NE  1 
ATOM   1419 C CZ  . ARG A 1 186 ? 5.07475   -10.86996 28.88997  1.000 52.01770 ? 186 ARG A CZ  1 
ATOM   1420 N NH1 . ARG A 1 186 ? 4.03936   -10.56859 28.12108  1.000 55.69702 ? 186 ARG A NH1 1 
ATOM   1421 N NH2 . ARG A 1 186 ? 4.88547   -11.04187 30.19513  1.000 54.10943 ? 186 ARG A NH2 1 
ATOM   1422 N N   . GLU A 1 187 ? 9.12141   -5.96763  23.80958  1.000 26.61803 ? 187 GLU A N   1 
ATOM   1423 C CA  . GLU A 1 187 ? 10.25695  -5.49366  23.02956  1.000 28.66690 ? 187 GLU A CA  1 
ATOM   1424 C C   . GLU A 1 187 ? 11.19115  -4.68422  23.93143  1.000 31.05229 ? 187 GLU A C   1 
ATOM   1425 O O   . GLU A 1 187 ? 10.74514  -3.80281  24.67621  1.000 21.46975 ? 187 GLU A O   1 
ATOM   1426 C CB  . GLU A 1 187 ? 9.79819   -4.64471  21.84345  1.000 34.04014 ? 187 GLU A CB  1 
ATOM   1427 C CG  . GLU A 1 187 ? 10.57164  -4.88874  20.54661  1.000 49.13913 ? 187 GLU A CG  1 
ATOM   1428 C CD  . GLU A 1 187 ? 10.63577  -6.36503  20.15554  1.000 48.93200 ? 187 GLU A CD  1 
ATOM   1429 O OE1 . GLU A 1 187 ? 9.57809   -7.02733  20.11874  1.000 45.85959 ? 187 GLU A OE1 1 
ATOM   1430 O OE2 . GLU A 1 187 ? 11.75285  -6.86672  19.89684  1.000 48.27356 ? 187 GLU A OE2 1 
ATOM   1431 N N   . LEU A 1 188 ? 12.47963  -4.99728  23.86258  1.000 20.02742 ? 188 LEU A N   1 
ATOM   1432 C CA  . LEU A 1 188 ? 13.49875  -4.26643  24.60235  1.000 18.61691 ? 188 LEU A CA  1 
ATOM   1433 C C   . LEU A 1 188 ? 13.56516  -2.82213  24.12049  1.000 22.27500 ? 188 LEU A C   1 
ATOM   1434 O O   . LEU A 1 188 ? 13.89139  -2.57425  22.95613  1.000 24.73205 ? 188 LEU A O   1 
ATOM   1435 C CB  . LEU A 1 188 ? 14.85068  -4.95633  24.40087  1.000 17.50579 ? 188 LEU A CB  1 
ATOM   1436 C CG  . LEU A 1 188 ? 15.99218  -4.34246  25.20140  1.000 18.81937 ? 188 LEU A CG  1 
ATOM   1437 C CD1 . LEU A 1 188 ? 15.81513  -4.76864  26.63554  1.000 20.07445 ? 188 LEU A CD1 1 
ATOM   1438 C CD2 . LEU A 1 188 ? 17.32983  -4.80284  24.66952  1.000 21.29849 ? 188 LEU A CD2 1 
ATOM   1439 N N   . VAL A 1 189 ? 13.25056  -1.85600  24.99253  1.000 16.90221 ? 189 VAL A N   1 
ATOM   1440 C CA  . VAL A 1 189 ? 13.39491  -0.45546  24.60009  1.000 15.70788 ? 189 VAL A CA  1 
ATOM   1441 C C   . VAL A 1 189 ? 14.58855  0.21009   25.22851  1.000 16.52510 ? 189 VAL A C   1 
ATOM   1442 O O   . VAL A 1 189 ? 14.99577  1.27214   24.72597  1.000 15.42041 ? 189 VAL A O   1 
ATOM   1443 C CB  . VAL A 1 189 ? 12.14759  0.41408   24.87645  1.000 24.92429 ? 189 VAL A CB  1 
ATOM   1444 C CG1 . VAL A 1 189 ? 11.10519  0.30581   23.73202  1.000 38.50363 ? 189 VAL A CG1 1 
ATOM   1445 C CG2 . VAL A 1 189 ? 11.60379  0.19916   26.25075  1.000 25.00278 ? 189 VAL A CG2 1 
ATOM   1446 N N   . ALA A 1 190 ? 15.10695  -0.30102  26.34709  1.000 16.19581 ? 190 ALA A N   1 
ATOM   1447 C CA  . ALA A 1 190 ? 16.21110  0.36331   27.02378  1.000 13.28567 ? 190 ALA A CA  1 
ATOM   1448 C C   . ALA A 1 190 ? 16.97632  -0.63711  27.89431  1.000 8.84450  ? 190 ALA A C   1 
ATOM   1449 O O   . ALA A 1 190 ? 16.40912  -1.60728  28.39063  1.000 9.07012  ? 190 ALA A O   1 
ATOM   1450 C CB  . ALA A 1 190 ? 15.69138  1.52903   27.87436  1.000 13.11991 ? 190 ALA A CB  1 
ATOM   1451 N N   . GLU A 1 191 ? 18.26962  -0.38666  28.07700  1.000 10.58759 ? 191 GLU A N   1 
ATOM   1452 C CA  . GLU A 1 191 ? 19.07368  -1.16943  29.00358  1.000 11.93242 ? 191 GLU A CA  1 
ATOM   1453 C C   . GLU A 1 191 ? 20.08867  -0.22171  29.61843  1.000 5.52723  ? 191 GLU A C   1 
ATOM   1454 O O   . GLU A 1 191 ? 20.66709  0.59166   28.90445  1.000 10.33095 ? 191 GLU A O   1 
ATOM   1455 C CB  . GLU A 1 191 ? 19.75202  -2.32950  28.25502  1.000 14.21290 ? 191 GLU A CB  1 
ATOM   1456 C CG  . GLU A 1 191 ? 20.64565  -3.23594  29.05808  1.000 16.32676 ? 191 GLU A CG  1 
ATOM   1457 C CD  . GLU A 1 191 ? 21.33960  -4.23553  28.12456  1.000 29.84130 ? 191 GLU A CD  1 
ATOM   1458 O OE1 . GLU A 1 191 ? 22.24236  -3.81742  27.36589  1.000 23.22853 ? 191 GLU A OE1 1 
ATOM   1459 O OE2 . GLU A 1 191 ? 20.94529  -5.41884  28.12375  1.000 25.53188 ? 191 GLU A OE2 1 
ATOM   1460 N N   . PHE A 1 192 ? 20.29734  -0.31279  30.92647  1.000 5.10757  ? 192 PHE A N   1 
ATOM   1461 C CA  . PHE A 1 192 ? 21.25581  0.55360   31.59649  1.000 6.40367  ? 192 PHE A CA  1 
ATOM   1462 C C   . PHE A 1 192 ? 21.97001  -0.27919  32.65242  1.000 10.23958 ? 192 PHE A C   1 
ATOM   1463 O O   . PHE A 1 192 ? 21.63756  -1.44537  32.87030  1.000 8.03044  ? 192 PHE A O   1 
ATOM   1464 C CB  . PHE A 1 192 ? 20.56504  1.78110   32.20319  1.000 8.00514  ? 192 PHE A CB  1 
ATOM   1465 C CG  . PHE A 1 192 ? 19.45063  1.42904   33.12429  1.000 11.92632 ? 192 PHE A CG  1 
ATOM   1466 C CD1 . PHE A 1 192 ? 18.18301  1.21354   32.63727  1.000 13.87789 ? 192 PHE A CD1 1 
ATOM   1467 C CD2 . PHE A 1 192 ? 19.68232  1.25566   34.46593  1.000 10.64080 ? 192 PHE A CD2 1 
ATOM   1468 C CE1 . PHE A 1 192 ? 17.15990  0.86020   33.49248  1.000 11.11228 ? 192 PHE A CE1 1 
ATOM   1469 C CE2 . PHE A 1 192 ? 18.65877  0.89640   35.31411  1.000 11.83290 ? 192 PHE A CE2 1 
ATOM   1470 C CZ  . PHE A 1 192 ? 17.40873  0.70450   34.82556  1.000 10.82109 ? 192 PHE A CZ  1 
ATOM   1471 N N   A CYS A 1 193 ? 22.99153  0.27837   33.29153  0.420 7.53492  ? 193 CYS A N   1 
ATOM   1472 N N   B CYS A 1 193 ? 22.92517  0.36389   33.33531  0.580 7.14872  ? 193 CYS A N   1 
ATOM   1473 C CA  A CYS A 1 193 ? 23.64801  -0.49349  34.33749  0.420 9.36282  ? 193 CYS A CA  1 
ATOM   1474 C CA  B CYS A 1 193 ? 23.80619  -0.29291  34.29630  0.580 9.57715  ? 193 CYS A CA  1 
ATOM   1475 C C   A CYS A 1 193 ? 23.89316  0.38304   35.54860  0.420 7.89861  ? 193 CYS A C   1 
ATOM   1476 C C   B CYS A 1 193 ? 23.84846  0.51515   35.58249  0.580 7.77987  ? 193 CYS A C   1 
ATOM   1477 O O   A CYS A 1 193 ? 24.56329  1.41347   35.46329  0.420 10.78176 ? 193 CYS A O   1 
ATOM   1478 O O   B CYS A 1 193 ? 24.38230  1.62653   35.60355  0.580 10.57152 ? 193 CYS A O   1 
ATOM   1479 C CB  A CYS A 1 193 ? 24.95861  -1.13256  33.86600  0.420 11.13265 ? 193 CYS A CB  1 
ATOM   1480 C CB  B CYS A 1 193 ? 25.22309  -0.43377  33.73732  0.580 9.75795  ? 193 CYS A CB  1 
ATOM   1481 S SG  A CYS A 1 193 ? 25.38852  -2.59272  34.87600  0.420 13.33922 ? 193 CYS A SG  1 
ATOM   1482 S SG  B CYS A 1 193 ? 25.30388  -1.33519  32.21645  0.580 12.11317 ? 193 CYS A SG  1 
ATOM   1483 N N   . LEU A 1 194 ? 23.33144  -0.03913  36.66403  1.000 7.42830  ? 194 LEU A N   1 
ATOM   1484 C CA  . LEU A 1 194 ? 23.61816  0.55551   37.95305  1.000 9.19678  ? 194 LEU A CA  1 
ATOM   1485 C C   . LEU A 1 194 ? 25.00970  0.10130   38.36961  1.000 10.91707 ? 194 LEU A C   1 
ATOM   1486 O O   . LEU A 1 194 ? 25.26870  -1.10306  38.46204  1.000 13.61534 ? 194 LEU A O   1 
ATOM   1487 C CB  . LEU A 1 194 ? 22.56642  0.11630   38.96279  1.000 13.38683 ? 194 LEU A CB  1 
ATOM   1488 C CG  . LEU A 1 194 ? 21.12939  0.36519   38.52867  1.000 10.32993 ? 194 LEU A CG  1 
ATOM   1489 C CD1 . LEU A 1 194 ? 20.25070  -0.32852  39.54249  1.000 7.64595  ? 194 LEU A CD1 1 
ATOM   1490 C CD2 . LEU A 1 194 ? 20.82068  1.85681   38.47365  1.000 6.14976  ? 194 LEU A CD2 1 
ATOM   1491 N N   . THR A 1 195 ? 25.90990  1.03994   38.58387  1.000 8.72665  ? 195 THR A N   1 
ATOM   1492 C CA  . THR A 1 195 ? 27.28603  0.63049   38.80710  1.000 13.06400 ? 195 THR A CA  1 
ATOM   1493 C C   . THR A 1 195 ? 27.85896  1.19955   40.09433  1.000 11.82481 ? 195 THR A C   1 
ATOM   1494 O O   . THR A 1 195 ? 28.66714  0.53540   40.73789  1.000 15.92497 ? 195 THR A O   1 
ATOM   1495 C CB  . THR A 1 195 ? 28.18357  1.03891   37.61812  1.000 14.09832 ? 195 THR A CB  1 
ATOM   1496 O OG1 . THR A 1 195 ? 27.97187  2.41871   37.32353  1.000 17.09558 ? 195 THR A OG1 1 
ATOM   1497 C CG2 . THR A 1 195 ? 27.88097  0.20417   36.37196  1.000 11.47062 ? 195 THR A CG2 1 
ATOM   1498 N N   . GLU A 1 196 ? 27.47792  2.41488   40.47379  1.000 10.75893 ? 196 GLU A N   1 
ATOM   1499 C CA  . GLU A 1 196 ? 28.00661  3.06770   41.66464  1.000 18.35857 ? 196 GLU A CA  1 
ATOM   1500 C C   . GLU A 1 196 ? 27.00342  2.95735   42.79278  1.000 15.02437 ? 196 GLU A C   1 
ATOM   1501 O O   . GLU A 1 196 ? 25.79482  2.87026   42.56843  1.000 9.52796  ? 196 GLU A O   1 
ATOM   1502 C CB  . GLU A 1 196 ? 28.31859  4.54928   41.40605  1.000 14.76661 ? 196 GLU A CB  1 
ATOM   1503 C CG  . GLU A 1 196 ? 29.40120  4.76315   40.37149  1.000 17.47547 ? 196 GLU A CG  1 
ATOM   1504 C CD  . GLU A 1 196 ? 30.74432  4.21194   40.83674  1.000 35.76599 ? 196 GLU A CD  1 
ATOM   1505 O OE1 . GLU A 1 196 ? 31.13203  4.48451   41.99263  1.000 36.37769 ? 196 GLU A OE1 1 
ATOM   1506 O OE2 . GLU A 1 196 ? 31.40331  3.48950   40.05773  1.000 44.54495 ? 196 GLU A OE2 1 
ATOM   1507 N N   . GLN A 1 197 ? 27.51546  2.96398   44.01067  1.000 9.46265  ? 197 GLN A N   1 
ATOM   1508 C CA  . GLN A 1 197 ? 26.63495  2.91738   45.16054  1.000 9.74906  ? 197 GLN A CA  1 
ATOM   1509 C C   . GLN A 1 197 ? 25.68611  4.11195   45.13956  1.000 12.98933 ? 197 GLN A C   1 
ATOM   1510 O O   . GLN A 1 197 ? 26.10891  5.25447   44.93891  1.000 13.20267 ? 197 GLN A O   1 
ATOM   1511 C CB  . GLN A 1 197 ? 27.44958  2.90389   46.45163  1.000 8.99398  ? 197 GLN A CB  1 
ATOM   1512 C CG  . GLN A 1 197 ? 26.58903  2.82796   47.67581  1.000 9.50311  ? 197 GLN A CG  1 
ATOM   1513 C CD  . GLN A 1 197 ? 27.41255  2.71669   48.93084  1.000 15.61519 ? 197 GLN A CD  1 
ATOM   1514 O OE1 . GLN A 1 197 ? 28.14688  3.63223   49.28174  1.000 13.40390 ? 197 GLN A OE1 1 
ATOM   1515 N NE2 . GLN A 1 197 ? 27.28960  1.59337   49.61571  1.000 13.19839 ? 197 GLN A NE2 1 
ATOM   1516 N N   . MET A 1 198 ? 24.40535  3.82567   45.36079  1.000 14.78681 ? 198 MET A N   1 
ATOM   1517 C CA  . MET A 1 198 ? 23.24031  4.71197   45.31259  1.000 8.92325  ? 198 MET A CA  1 
ATOM   1518 C C   . MET A 1 198 ? 22.82702  5.08264   43.89588  1.000 13.56901 ? 198 MET A C   1 
ATOM   1519 O O   . MET A 1 198 ? 21.93817  5.95194   43.76571  1.000 10.60489 ? 198 MET A O   1 
ATOM   1520 C CB  . MET A 1 198 ? 23.42144  5.99956   46.12634  1.000 10.07869 ? 198 MET A CB  1 
ATOM   1521 C CG  . MET A 1 198 ? 23.25974  5.79217   47.64115  1.000 15.83778 ? 198 MET A CG  1 
ATOM   1522 S SD  . MET A 1 198 ? 21.78211  4.83000   48.09036  1.000 21.07372 ? 198 MET A SD  1 
ATOM   1523 C CE  . MET A 1 198 ? 20.46961  5.93954   47.69976  1.000 12.19603 ? 198 MET A CE  1 
ATOM   1524 N N   . ASP A 1 199 ? 23.40581  4.48908   42.84326  1.000 7.70099  ? 199 ASP A N   1 
ATOM   1525 C CA  . ASP A 1 199 ? 22.81165  4.65399   41.52408  1.000 7.06646  ? 199 ASP A CA  1 
ATOM   1526 C C   . ASP A 1 199 ? 21.37493  4.14633   41.59413  1.000 5.45675  ? 199 ASP A C   1 
ATOM   1527 O O   . ASP A 1 199 ? 21.09692  3.13289   42.23706  1.000 7.21300  ? 199 ASP A O   1 
ATOM   1528 C CB  . ASP A 1 199 ? 23.57787  3.87685   40.44511  1.000 8.58490  ? 199 ASP A CB  1 
ATOM   1529 C CG  . ASP A 1 199 ? 24.80134  4.59851   39.92460  1.000 9.39308  ? 199 ASP A CG  1 
ATOM   1530 O OD1 . ASP A 1 199 ? 25.12252  5.70808   40.39019  1.000 12.11785 ? 199 ASP A OD1 1 
ATOM   1531 O OD2 . ASP A 1 199 ? 25.44909  4.03266   39.01986  1.000 8.56047  ? 199 ASP A OD2 1 
ATOM   1532 N N   . THR A 1 200 ? 20.45461  4.83908   40.92537  1.000 7.64649  ? 200 THR A N   1 
ATOM   1533 C CA  . THR A 1 200 ? 19.03534  4.64618   41.20826  1.000 6.67421  ? 200 THR A CA  1 
ATOM   1534 C C   . THR A 1 200 ? 18.25604  4.60156   39.90112  1.000 5.51043  ? 200 THR A C   1 
ATOM   1535 O O   . THR A 1 200 ? 18.60706  5.28399   38.93747  1.000 8.11772  ? 200 THR A O   1 
ATOM   1536 C CB  . THR A 1 200 ? 18.50745  5.78787   42.12252  1.000 6.90759  ? 200 THR A CB  1 
ATOM   1537 O OG1 . THR A 1 200 ? 19.07562  5.68109   43.44067  1.000 8.73299  ? 200 THR A OG1 1 
ATOM   1538 C CG2 . THR A 1 200 ? 17.00827  5.78085   42.24665  1.000 5.91984  ? 200 THR A CG2 1 
ATOM   1539 N N   . MET A 1 201 ? 17.20553  3.77953   39.86819  1.000 6.42048  ? 201 MET A N   1 
ATOM   1540 C CA  . MET A 1 201 ? 16.21396  3.83878   38.79514  1.000 5.82153  ? 201 MET A CA  1 
ATOM   1541 C C   . MET A 1 201 ? 14.81079  3.91402   39.37801  1.000 5.92214  ? 201 MET A C   1 
ATOM   1542 O O   . MET A 1 201 ? 14.49630  3.19921   40.33313  1.000 8.82721  ? 201 MET A O   1 
ATOM   1543 C CB  . MET A 1 201 ? 16.30401  2.61156   37.86053  1.000 4.21635  ? 201 MET A CB  1 
ATOM   1544 C CG  . MET A 1 201 ? 15.32382  2.68160   36.68272  1.000 8.33505  ? 201 MET A CG  1 
ATOM   1545 S SD  . MET A 1 201 ? 13.94054  1.57488   36.92376  1.000 21.77398 ? 201 MET A SD  1 
ATOM   1546 C CE  . MET A 1 201 ? 14.74726  -0.02551  37.00581  1.000 9.88210  ? 201 MET A CE  1 
ATOM   1547 N N   . PHE A 1 202 ? 13.95782  4.76352   38.78666  1.000 11.58132 ? 202 PHE A N   1 
ATOM   1548 C CA  . PHE A 1 202 ? 12.52584  4.80529   39.09015  1.000 8.72142  ? 202 PHE A CA  1 
ATOM   1549 C C   . PHE A 1 202 ? 11.74335  4.25061   37.90225  1.000 7.15061  ? 202 PHE A C   1 
ATOM   1550 O O   . PHE A 1 202 ? 12.13592  4.46041   36.75610  1.000 8.54492  ? 202 PHE A O   1 
ATOM   1551 C CB  . PHE A 1 202 ? 12.05470  6.25170   39.36846  1.000 7.91287  ? 202 PHE A CB  1 
ATOM   1552 C CG  . PHE A 1 202 ? 12.94172  7.03091   40.30949  1.000 10.46834 ? 202 PHE A CG  1 
ATOM   1553 C CD1 . PHE A 1 202 ? 12.80492  6.89915   41.68577  1.000 9.92660  ? 202 PHE A CD1 1 
ATOM   1554 C CD2 . PHE A 1 202 ? 13.86611  7.94534   39.81814  1.000 10.96484 ? 202 PHE A CD2 1 
ATOM   1555 C CE1 . PHE A 1 202 ? 13.62166  7.62470   42.55851  1.000 12.51182 ? 202 PHE A CE1 1 
ATOM   1556 C CE2 . PHE A 1 202 ? 14.67844  8.68102   40.67913  1.000 12.77019 ? 202 PHE A CE2 1 
ATOM   1557 C CZ  . PHE A 1 202 ? 14.55861  8.51277   42.05752  1.000 13.92078 ? 202 PHE A CZ  1 
ATOM   1558 N N   . TRP A 1 203 ? 10.59160  3.62450   38.14731  1.000 9.68403  ? 203 TRP A N   1 
ATOM   1559 C CA  . TRP A 1 203 ? 9.79172   3.17860   37.00341  1.000 9.11592  ? 203 TRP A CA  1 
ATOM   1560 C C   . TRP A 1 203 ? 8.31028   3.16430   37.33798  1.000 8.74523  ? 203 TRP A C   1 
ATOM   1561 O O   . TRP A 1 203 ? 7.90626   3.00893   38.49357  1.000 8.55027  ? 203 TRP A O   1 
ATOM   1562 C CB  . TRP A 1 203 ? 10.20788  1.78723   36.47482  1.000 7.40608  ? 203 TRP A CB  1 
ATOM   1563 C CG  . TRP A 1 203 ? 9.74157   0.58189   37.24457  1.000 8.83807  ? 203 TRP A CG  1 
ATOM   1564 C CD1 . TRP A 1 203 ? 8.67093   -0.21065  36.95411  1.000 8.23625  ? 203 TRP A CD1 1 
ATOM   1565 C CD2 . TRP A 1 203 ? 10.37783  -0.01110  38.39653  1.000 8.66610  ? 203 TRP A CD2 1 
ATOM   1566 N NE1 . TRP A 1 203 ? 8.58075   -1.24377  37.85778  1.000 11.09471 ? 203 TRP A NE1 1 
ATOM   1567 C CE2 . TRP A 1 203 ? 9.61500   -1.13931  38.75867  1.000 10.79583 ? 203 TRP A CE2 1 
ATOM   1568 C CE3 . TRP A 1 203 ? 11.51431  0.31603   39.15871  1.000 8.98208  ? 203 TRP A CE3 1 
ATOM   1569 C CZ2 . TRP A 1 203 ? 9.94548   -1.95473  39.85084  1.000 10.42957 ? 203 TRP A CZ2 1 
ATOM   1570 C CZ3 . TRP A 1 203 ? 11.84069  -0.49614  40.25121  1.000 5.97458  ? 203 TRP A CZ3 1 
ATOM   1571 C CH2 . TRP A 1 203 ? 11.05959  -1.61100  40.58903  1.000 10.39642 ? 203 TRP A CH2 1 
ATOM   1572 N N   . SER A 1 204 ? 7.49855   3.29878   36.28122  1.000 12.97920 ? 204 SER A N   1 
ATOM   1573 C CA  . SER A 1 204 ? 6.04164   3.16241   36.36233  1.000 10.06876 ? 204 SER A CA  1 
ATOM   1574 C C   . SER A 1 204 ? 5.65973   1.71686   36.06081  1.000 13.83688 ? 204 SER A C   1 
ATOM   1575 O O   . SER A 1 204 ? 5.74302   1.27840   34.90450  1.000 12.06895 ? 204 SER A O   1 
ATOM   1576 C CB  . SER A 1 204 ? 5.36124   4.11218   35.37757  1.000 11.63969 ? 204 SER A CB  1 
ATOM   1577 O OG  . SER A 1 204 ? 5.78390   5.44772   35.59321  1.000 22.98048 ? 204 SER A OG  1 
ATOM   1578 N N   . ASP A 1 205 ? 5.18875   0.99228   37.08399  1.000 7.38645  ? 205 ASP A N   1 
ATOM   1579 C CA  . ASP A 1 205 ? 5.15234   -0.45815  36.98204  1.000 12.30461 ? 205 ASP A CA  1 
ATOM   1580 C C   . ASP A 1 205 ? 4.05154   -0.98580  36.06228  1.000 17.48114 ? 205 ASP A C   1 
ATOM   1581 O O   . ASP A 1 205 ? 4.12464   -2.14488  35.64426  1.000 12.98931 ? 205 ASP A O   1 
ATOM   1582 C CB  . ASP A 1 205 ? 4.97985   -1.09497  38.35283  1.000 8.00978  ? 205 ASP A CB  1 
ATOM   1583 C CG  . ASP A 1 205 ? 5.13714   -2.59679  38.30015  1.000 12.32377 ? 205 ASP A CG  1 
ATOM   1584 O OD1 . ASP A 1 205 ? 6.22589   -3.03568  37.89750  1.000 11.62556 ? 205 ASP A OD1 1 
ATOM   1585 O OD2 . ASP A 1 205 ? 4.19395   -3.34643  38.63404  1.000 15.30553 ? 205 ASP A OD2 1 
ATOM   1586 N N   . GLY A 1 206 ? 3.02848   -0.19409  35.76358  1.000 13.99511 ? 206 GLY A N   1 
ATOM   1587 C CA  . GLY A 1 206 ? 2.01585   -0.64649  34.83338  1.000 20.28208 ? 206 GLY A CA  1 
ATOM   1588 C C   . GLY A 1 206 ? 2.27690   -0.23928  33.40917  1.000 24.24042 ? 206 GLY A C   1 
ATOM   1589 O O   . GLY A 1 206 ? 1.50743   -0.58324  32.50697  1.000 24.89987 ? 206 GLY A O   1 
ATOM   1590 N N   . GLN A 1 207 ? 3.36236   0.49138   33.17772  1.000 17.97761 ? 207 GLN A N   1 
ATOM   1591 C CA  . GLN A 1 207 ? 3.65239   1.06217   31.87814  1.000 20.61042 ? 207 GLN A CA  1 
ATOM   1592 C C   . GLN A 1 207 ? 4.76707   0.34454   31.13871  1.000 31.40693 ? 207 GLN A C   1 
ATOM   1593 O O   . GLN A 1 207 ? 4.81077   0.41330   29.90799  1.000 23.11439 ? 207 GLN A O   1 
ATOM   1594 C CB  . GLN A 1 207 ? 4.01324   2.53709   32.04346  1.000 15.51822 ? 207 GLN A CB  1 
ATOM   1595 C CG  . GLN A 1 207 ? 4.10729   3.36174   30.78706  1.000 21.00746 ? 207 GLN A CG  1 
ATOM   1596 C CD  . GLN A 1 207 ? 4.32926   4.82293   31.11532  1.000 25.75587 ? 207 GLN A CD  1 
ATOM   1597 O OE1 . GLN A 1 207 ? 3.78944   5.32568   32.09438  1.000 28.59939 ? 207 GLN A OE1 1 
ATOM   1598 N NE2 . GLN A 1 207 ? 5.15681   5.50145   30.32541  1.000 31.45235 ? 207 GLN A NE2 1 
ATOM   1599 N N   . ILE A 1 208 ? 5.66672   -0.34449  31.85140  1.000 19.02991 ? 208 ILE A N   1 
ATOM   1600 C CA  . ILE A 1 208 ? 6.75549   -1.09812  31.23668  1.000 14.12697 ? 208 ILE A CA  1 
ATOM   1601 C C   . ILE A 1 208 ? 6.81204   -2.45949  31.90226  1.000 9.63488  ? 208 ILE A C   1 
ATOM   1602 O O   . ILE A 1 208 ? 6.14916   -2.71482  32.90494  1.000 14.45234 ? 208 ILE A O   1 
ATOM   1603 C CB  . ILE A 1 208 ? 8.12558   -0.39978  31.37818  1.000 12.28947 ? 208 ILE A CB  1 
ATOM   1604 C CG1 . ILE A 1 208 ? 8.42572   -0.12696  32.86138  1.000 14.25456 ? 208 ILE A CG1 1 
ATOM   1605 C CG2 . ILE A 1 208 ? 8.17643   0.85763   30.59508  1.000 13.13596 ? 208 ILE A CG2 1 
ATOM   1606 C CD1 . ILE A 1 208 ? 9.91206   0.22006   33.15144  1.000 18.67233 ? 208 ILE A CD1 1 
ATOM   1607 N N   . LEU A 1 209 ? 7.62825   -3.33105  31.33319  1.000 10.73431 ? 209 LEU A N   1 
ATOM   1608 C CA  . LEU A 1 209 ? 8.09347   -4.53241  32.00184  1.000 13.16976 ? 209 LEU A CA  1 
ATOM   1609 C C   . LEU A 1 209 ? 9.59141   -4.37704  32.19333  1.000 10.88991 ? 209 LEU A C   1 
ATOM   1610 O O   . LEU A 1 209 ? 10.22411  -3.53448  31.55157  1.000 14.03850 ? 209 LEU A O   1 
ATOM   1611 C CB  . LEU A 1 209 ? 7.78602   -5.80131  31.19487  1.000 16.33009 ? 209 LEU A CB  1 
ATOM   1612 C CG  . LEU A 1 209 ? 6.30402   -6.02981  30.84160  1.000 16.23445 ? 209 LEU A CG  1 
ATOM   1613 C CD1 . LEU A 1 209 ? 6.16121   -7.07995  29.74138  1.000 13.33606 ? 209 LEU A CD1 1 
ATOM   1614 C CD2 . LEU A 1 209 ? 5.50088   -6.42132  32.07144  1.000 13.35199 ? 209 LEU A CD2 1 
ATOM   1615 N N   . HIS A 1 210 ? 10.16508  -5.17718  33.08526  1.000 13.95131 ? 210 HIS A N   1 
ATOM   1616 C CA  . HIS A 1 210 ? 11.58486  -5.01000  33.34135  1.000 13.68308 ? 210 HIS A CA  1 
ATOM   1617 C C   . HIS A 1 210 ? 12.18989  -6.34730  33.71736  1.000 14.59345 ? 210 HIS A C   1 
ATOM   1618 O O   . HIS A 1 210 ? 11.48587  -7.31071  34.03556  1.000 16.10708 ? 210 HIS A O   1 
ATOM   1619 C CB  . HIS A 1 210 ? 11.84203  -3.95979  34.43510  1.000 10.40713 ? 210 HIS A CB  1 
ATOM   1620 C CG  . HIS A 1 210 ? 11.35490  -4.36756  35.79209  1.000 18.71235 ? 210 HIS A CG  1 
ATOM   1621 N ND1 . HIS A 1 210 ? 10.02385  -4.32695  36.14653  1.000 15.62227 ? 210 HIS A ND1 1 
ATOM   1622 C CD2 . HIS A 1 210 ? 12.01418  -4.83969  36.87623  1.000 22.42071 ? 210 HIS A CD2 1 
ATOM   1623 C CE1 . HIS A 1 210 ? 9.88274   -4.74990  37.38957  1.000 15.11126 ? 210 HIS A CE1 1 
ATOM   1624 N NE2 . HIS A 1 210 ? 11.07708  -5.06763  37.85824  1.000 24.08423 ? 210 HIS A NE2 1 
ATOM   1625 N N   . ALA A 1 211 ? 13.51967  -6.37708  33.70311  1.000 17.47103 ? 211 ALA A N   1 
ATOM   1626 C CA  . ALA A 1 211 ? 14.27885  -7.58054  33.98903  1.000 14.19482 ? 211 ALA A CA  1 
ATOM   1627 C C   . ALA A 1 211 ? 15.70405  -7.15616  34.28430  1.000 12.71697 ? 211 ALA A C   1 
ATOM   1628 O O   . ALA A 1 211 ? 16.09291  -6.02026  34.02559  1.000 9.52564  ? 211 ALA A O   1 
ATOM   1629 C CB  . ALA A 1 211 ? 14.23998  -8.56624  32.81139  1.000 13.80051 ? 211 ALA A CB  1 
ATOM   1630 N N   . VAL A 1 212 ? 16.48346  -8.08002  34.82011  1.000 14.71442 ? 212 VAL A N   1 
ATOM   1631 C CA  . VAL A 1 212 ? 17.89356  -7.82209  35.08479  1.000 19.03052 ? 212 VAL A CA  1 
ATOM   1632 C C   . VAL A 1 212 ? 18.69517  -9.02513  34.61574  1.000 14.40340 ? 212 VAL A C   1 
ATOM   1633 O O   . VAL A 1 212 ? 18.30209  -10.16940 34.86063  1.000 15.16373 ? 212 VAL A O   1 
ATOM   1634 C CB  . VAL A 1 212 ? 18.15221  -7.51180  36.57331  1.000 16.96927 ? 212 VAL A CB  1 
ATOM   1635 C CG1 . VAL A 1 212 ? 17.90197  -8.72574  37.45842  1.000 15.25449 ? 212 VAL A CG1 1 
ATOM   1636 C CG2 . VAL A 1 212 ? 19.57154  -6.97308  36.76626  1.000 9.83471  ? 212 VAL A CG2 1 
ATOM   1637 N N   . ARG A 1 213 ? 19.78136  -8.76484  33.89039  1.000 15.09014 ? 213 ARG A N   1 
ATOM   1638 C CA  . ARG A 1 213 ? 20.63207  -9.83248  33.40119  1.000 12.62407 ? 213 ARG A CA  1 
ATOM   1639 C C   . ARG A 1 213 ? 21.37446  -10.48365 34.56073  1.000 18.04724 ? 213 ARG A C   1 
ATOM   1640 O O   . ARG A 1 213 ? 21.65117  -9.82960  35.57406  1.000 18.48086 ? 213 ARG A O   1 
ATOM   1641 C CB  . ARG A 1 213 ? 21.65407  -9.30030  32.39913  1.000 14.02061 ? 213 ARG A CB  1 
ATOM   1642 C CG  . ARG A 1 213 ? 21.09527  -8.90331  31.05948  1.000 21.63490 ? 213 ARG A CG  1 
ATOM   1643 C CD  . ARG A 1 213 ? 22.20750  -8.91277  30.01376  1.000 23.78728 ? 213 ARG A CD  1 
ATOM   1644 N NE  . ARG A 1 213 ? 21.77429  -8.35962  28.73689  1.000 29.74872 ? 213 ARG A NE  1 
ATOM   1645 C CZ  . ARG A 1 213 ? 21.22932  -9.08200  27.76617  1.000 37.12254 ? 213 ARG A CZ  1 
ATOM   1646 N NH1 . ARG A 1 213 ? 21.05536  -10.38995 27.89119  1.000 34.63322 ? 213 ARG A NH1 1 
ATOM   1647 N NH2 . ARG A 1 213 ? 20.84027  -8.47695  26.64758  1.000 33.06495 ? 213 ARG A NH2 1 
ATOM   1648 N N   . PRO A 1 214 ? 21.72786  -11.76260 34.42674  1.000 18.15404 ? 214 PRO A N   1 
ATOM   1649 C CA  . PRO A 1 214 ? 22.57463  -12.40550 35.44280  1.000 21.74023 ? 214 PRO A CA  1 
ATOM   1650 C C   . PRO A 1 214 ? 23.86775  -11.63339 35.64765  1.000 17.45669 ? 214 PRO A C   1 
ATOM   1651 O O   . PRO A 1 214 ? 24.32452  -10.90632 34.76518  1.000 14.13266 ? 214 PRO A O   1 
ATOM   1652 C CB  . PRO A 1 214 ? 22.85199  -13.79320 34.85046  1.000 19.04035 ? 214 PRO A CB  1 
ATOM   1653 C CG  . PRO A 1 214 ? 21.75103  -14.01341 33.84781  1.000 35.51546 ? 214 PRO A CG  1 
ATOM   1654 C CD  . PRO A 1 214 ? 21.42652  -12.65596 33.29551  1.000 19.32954 ? 214 PRO A CD  1 
ATOM   1655 N N   . ILE A 1 215 ? 24.44742  -11.77921 36.83442  1.000 16.46472 ? 215 ILE A N   1 
ATOM   1656 C CA  . ILE A 1 215 ? 25.77907  -11.25502 37.08782  1.000 14.79582 ? 215 ILE A CA  1 
ATOM   1657 C C   . ILE A 1 215 ? 26.77961  -12.39114 36.92898  1.000 16.49682 ? 215 ILE A C   1 
ATOM   1658 O O   . ILE A 1 215 ? 26.44347  -13.56706 37.06763  1.000 18.59216 ? 215 ILE A O   1 
ATOM   1659 C CB  . ILE A 1 215 ? 25.90288  -10.60260 38.48109  1.000 15.97682 ? 215 ILE A CB  1 
ATOM   1660 C CG1 . ILE A 1 215 ? 25.70030  -11.61968 39.61788  1.000 15.98098 ? 215 ILE A CG1 1 
ATOM   1661 C CG2 . ILE A 1 215 ? 24.92444  -9.40709  38.60146  1.000 21.35212 ? 215 ILE A CG2 1 
ATOM   1662 C CD1 . ILE A 1 215 ? 26.06030  -11.06123 41.01511  1.000 9.56769  ? 215 ILE A CD1 1 
ATOM   1663 N N   . HIS A 1 216 ? 28.02003  -12.04569 36.62406  1.000 19.40204 ? 216 HIS A N   1 
ATOM   1664 C CA  . HIS A 1 216 ? 29.05518  -13.06938 36.62026  1.000 21.29164 ? 216 HIS A CA  1 
ATOM   1665 C C   . HIS A 1 216 ? 30.31972  -12.44670 37.13519  1.000 20.04933 ? 216 HIS A C   1 
ATOM   1666 O O   . HIS A 1 216 ? 30.50555  -11.21304 37.03220  1.000 18.80830 ? 216 HIS A O   1 
ATOM   1667 C CB  . HIS A 1 216 ? 29.25769  -13.68934 35.22422  1.000 24.80753 ? 216 HIS A CB  1 
ATOM   1668 C CG  . HIS A 1 216 ? 29.48060  -12.68416 34.14005  1.000 31.99793 ? 216 HIS A CG  1 
ATOM   1669 N ND1 . HIS A 1 216 ? 28.48778  -12.31240 33.26063  1.000 33.22231 ? 216 HIS A ND1 1 
ATOM   1670 C CD2 . HIS A 1 216 ? 30.58190  -11.97905 33.78410  1.000 40.94191 ? 216 HIS A CD2 1 
ATOM   1671 C CE1 . HIS A 1 216 ? 28.96348  -11.41873 32.41261  1.000 36.65799 ? 216 HIS A CE1 1 
ATOM   1672 N NE2 . HIS A 1 216 ? 30.23268  -11.19851 32.70792  1.000 46.67507 ? 216 HIS A NE2 1 
ATOM   1673 N N   . PRO A 1 217 ? 31.21676  -13.21351 37.75584  1.000 17.27043 ? 217 PRO A N   1 
ATOM   1674 C CA  . PRO A 1 217 ? 32.40255  -12.63719 38.37348  1.000 21.86049 ? 217 PRO A CA  1 
ATOM   1675 C C   . PRO A 1 217 ? 33.36734  -12.08195 37.34441  1.000 16.24284 ? 217 PRO A C   1 
ATOM   1676 O O   . PRO A 1 217 ? 33.51584  -12.61549 36.24202  1.000 21.61303 ? 217 PRO A O   1 
ATOM   1677 C CB  . PRO A 1 217 ? 33.02068  -13.80683 39.14105  1.000 17.94287 ? 217 PRO A CB  1 
ATOM   1678 C CG  . PRO A 1 217 ? 32.48994  -15.02793 38.46133  1.000 17.14434 ? 217 PRO A CG  1 
ATOM   1679 C CD  . PRO A 1 217 ? 31.10158  -14.66066 38.04310  1.000 20.24406 ? 217 PRO A CD  1 
ATOM   1680 N N   . VAL A 1 218 ? 34.00340  -10.97631 37.70406  1.000 14.38319 ? 218 VAL A N   1 
ATOM   1681 C CA  . VAL A 1 218 ? 35.12412  -10.48972 36.91094  1.000 20.80801 ? 218 VAL A CA  1 
ATOM   1682 C C   . VAL A 1 218 ? 36.34640  -11.36339 37.17023  1.000 31.73801 ? 218 VAL A C   1 
ATOM   1683 O O   . VAL A 1 218 ? 36.92119  -11.96198 36.25288  1.000 23.57750 ? 218 VAL A O   1 
ATOM   1684 C CB  . VAL A 1 218 ? 35.40291  -9.00910  37.22597  1.000 25.39888 ? 218 VAL A CB  1 
ATOM   1685 C CG1 . VAL A 1 218 ? 36.67852  -8.54154  36.52956  1.000 20.96074 ? 218 VAL A CG1 1 
ATOM   1686 C CG2 . VAL A 1 218 ? 34.20722  -8.12945  36.81208  1.000 26.91620 ? 218 VAL A CG2 1 
ATOM   1687 N N   . ASP A 1 219 ? 36.71622  -11.48910 38.44013  1.000 21.49919 ? 219 ASP A N   1 
ATOM   1688 C CA  . ASP A 1 219 ? 37.68469  -12.48493 38.87592  1.000 18.74459 ? 219 ASP A CA  1 
ATOM   1689 C C   . ASP A 1 219 ? 36.95467  -13.80095 39.10641  1.000 17.93337 ? 219 ASP A C   1 
ATOM   1690 O O   . ASP A 1 219 ? 36.25104  -13.96175 40.11049  1.000 19.49578 ? 219 ASP A O   1 
ATOM   1691 C CB  . ASP A 1 219 ? 38.39346  -12.00096 40.13393  1.000 25.23264 ? 219 ASP A CB  1 
ATOM   1692 C CG  . ASP A 1 219 ? 39.28367  -13.05967 40.76267  1.000 21.78615 ? 219 ASP A CG  1 
ATOM   1693 O OD1 . ASP A 1 219 ? 39.43530  -14.16055 40.19453  1.000 31.09050 ? 219 ASP A OD1 1 
ATOM   1694 O OD2 . ASP A 1 219 ? 39.82025  -12.78128 41.84734  1.000 26.20046 ? 219 ASP A OD2 1 
ATOM   1695 N N   . PRO A 1 220 ? 37.11309  -14.77912 38.21522  1.000 21.21217 ? 220 PRO A N   1 
ATOM   1696 C CA  . PRO A 1 220 ? 36.29778  -15.99516 38.31360  1.000 21.32095 ? 220 PRO A CA  1 
ATOM   1697 C C   . PRO A 1 220 ? 36.68570  -16.91038 39.46765  1.000 24.16318 ? 220 PRO A C   1 
ATOM   1698 O O   . PRO A 1 220 ? 35.98059  -17.89103 39.71352  1.000 31.56124 ? 220 PRO A O   1 
ATOM   1699 C CB  . PRO A 1 220 ? 36.52584  -16.66512 36.95925  1.000 33.89280 ? 220 PRO A CB  1 
ATOM   1700 C CG  . PRO A 1 220 ? 37.93940  -16.25856 36.61331  1.000 33.52795 ? 220 PRO A CG  1 
ATOM   1701 C CD  . PRO A 1 220 ? 38.09114  -14.85038 37.11569  1.000 24.54136 ? 220 PRO A CD  1 
ATOM   1702 N N   . THR A 1 221 ? 37.75682  -16.62186 40.19862  1.000 26.71972 ? 221 THR A N   1 
ATOM   1703 C CA  . THR A 1 221 ? 38.04953  -17.41189 41.38609  1.000 24.78626 ? 221 THR A CA  1 
ATOM   1704 C C   . THR A 1 221 ? 37.28290  -16.93854 42.61609  1.000 38.45950 ? 221 THR A C   1 
ATOM   1705 O O   . THR A 1 221 ? 37.37950  -17.58197 43.66940  1.000 29.47380 ? 221 THR A O   1 
ATOM   1706 C CB  . THR A 1 221 ? 39.54904  -17.38834 41.67988  1.000 23.45813 ? 221 THR A CB  1 
ATOM   1707 O OG1 . THR A 1 221 ? 39.90647  -16.12363 42.23697  1.000 29.29144 ? 221 THR A OG1 1 
ATOM   1708 C CG2 . THR A 1 221 ? 40.35216  -17.60274 40.40076  1.000 31.35429 ? 221 THR A CG2 1 
ATOM   1709 N N   . LYS A 1 222 ? 36.51089  -15.85300 42.50231  1.000 31.69449 ? 222 LYS A N   1 
ATOM   1710 C CA  . LYS A 1 222 ? 35.78537  -15.26331 43.61929  1.000 30.82114 ? 222 LYS A CA  1 
ATOM   1711 C C   . LYS A 1 222 ? 34.30556  -15.11510 43.27432  1.000 27.84132 ? 222 LYS A C   1 
ATOM   1712 O O   . LYS A 1 222 ? 33.90327  -15.15514 42.10775  1.000 22.89040 ? 222 LYS A O   1 
ATOM   1713 C CB  . LYS A 1 222 ? 36.36188  -13.89036 43.99360  1.000 35.48899 ? 222 LYS A CB  1 
ATOM   1714 C CG  . LYS A 1 222 ? 37.37836  -13.89279 45.11211  1.000 31.88921 ? 222 LYS A CG  1 
ATOM   1715 C CD  . LYS A 1 222 ? 38.76824  -14.15410 44.59663  1.000 42.35902 ? 222 LYS A CD  1 
ATOM   1716 C CE  . LYS A 1 222 ? 39.76984  -14.03917 45.71285  1.000 37.96139 ? 222 LYS A CE  1 
ATOM   1717 N NZ  . LYS A 1 222 ? 39.70362  -12.69388 46.36548  1.000 36.60268 ? 222 LYS A NZ  1 
ATOM   1718 N N   . ALA A 1 223 ? 33.48741  -14.94349 44.30723  1.000 28.25970 ? 223 ALA A N   1 
ATOM   1719 C CA  . ALA A 1 223 ? 32.06835  -14.73167 44.07470  1.000 27.67808 ? 223 ALA A CA  1 
ATOM   1720 C C   . ALA A 1 223 ? 31.81392  -13.34438 43.48698  1.000 16.71091 ? 223 ALA A C   1 
ATOM   1721 O O   . ALA A 1 223 ? 32.56486  -12.39117 43.71521  1.000 15.77305 ? 223 ALA A O   1 
ATOM   1722 C CB  . ALA A 1 223 ? 31.28372  -14.90371 45.37700  1.000 30.63888 ? 223 ALA A CB  1 
ATOM   1723 N N   . ALA A 1 224 ? 30.73927  -13.23750 42.71765  1.000 22.82324 ? 224 ALA A N   1 
ATOM   1724 C CA  . ALA A 1 224 ? 30.20860  -11.94638 42.30282  1.000 15.86512 ? 224 ALA A CA  1 
ATOM   1725 C C   . ALA A 1 224 ? 28.95484  -11.65810 43.11952  1.000 16.48006 ? 224 ALA A C   1 
ATOM   1726 O O   . ALA A 1 224 ? 28.11751  -12.54865 43.30352  1.000 16.17993 ? 224 ALA A O   1 
ATOM   1727 C CB  . ALA A 1 224 ? 29.88481  -11.93436 40.81311  1.000 17.38747 ? 224 ALA A CB  1 
ATOM   1728 N N   . VAL A 1 225 ? 28.83969  -10.42559 43.61626  1.000 12.48407 ? 225 VAL A N   1 
ATOM   1729 C CA  . VAL A 1 225 ? 27.77278  -10.03870 44.54213  1.000 14.06964 ? 225 VAL A CA  1 
ATOM   1730 C C   . VAL A 1 225 ? 27.18191  -8.69612  44.08550  1.000 12.98542 ? 225 VAL A C   1 
ATOM   1731 O O   . VAL A 1 225 ? 27.92366  -7.76516  43.77612  1.000 10.93659 ? 225 VAL A O   1 
ATOM   1732 C CB  . VAL A 1 225 ? 28.29723  -9.93269  45.98515  1.000 12.81103 ? 225 VAL A CB  1 
ATOM   1733 C CG1 . VAL A 1 225 ? 27.19829  -9.42266  46.93732  1.000 12.53752 ? 225 VAL A CG1 1 
ATOM   1734 C CG2 . VAL A 1 225 ? 28.82238  -11.30682 46.47235  1.000 19.22534 ? 225 VAL A CG2 1 
ATOM   1735 N N   A ARG A 1 226 ? 25.84865  -8.61779  44.05451  0.377 11.42460 ? 226 ARG A N   1 
ATOM   1736 N N   B ARG A 1 226 ? 25.84501  -8.63561  44.04627  0.623 11.47124 ? 226 ARG A N   1 
ATOM   1737 C CA  A ARG A 1 226 ? 25.16021  -7.37508  43.70691  0.377 8.81597  ? 226 ARG A CA  1 
ATOM   1738 C CA  B ARG A 1 226 ? 25.10588  -7.42148  43.70184  0.623 8.34803  ? 226 ARG A CA  1 
ATOM   1739 C C   A ARG A 1 226 ? 24.04406  -7.13022  44.71649  0.377 9.58405  ? 226 ARG A C   1 
ATOM   1740 C C   B ARG A 1 226 ? 24.05973  -7.17062  44.78129  0.623 9.69671  ? 226 ARG A C   1 
ATOM   1741 O O   A ARG A 1 226 ? 23.11799  -7.93872  44.82875  0.377 9.24884  ? 226 ARG A O   1 
ATOM   1742 O O   B ARG A 1 226 ? 23.19444  -8.01995  45.00920  0.623 9.20552  ? 226 ARG A O   1 
ATOM   1743 C CB  A ARG A 1 226 ? 24.61455  -7.43143  42.27555  0.377 12.20102 ? 226 ARG A CB  1 
ATOM   1744 C CB  B ARG A 1 226 ? 24.44192  -7.56572  42.33108  0.623 12.12783 ? 226 ARG A CB  1 
ATOM   1745 C CG  A ARG A 1 226 ? 24.30116  -6.06018  41.64482  0.377 13.00230 ? 226 ARG A CG  1 
ATOM   1746 C CG  B ARG A 1 226 ? 23.68754  -6.32520  41.80507  0.623 11.29533 ? 226 ARG A CG  1 
ATOM   1747 C CD  A ARG A 1 226 ? 24.03429  -6.15422  40.13146  0.377 13.24908 ? 226 ARG A CD  1 
ATOM   1748 C CD  B ARG A 1 226 ? 23.18395  -6.58350  40.38499  0.623 13.25427 ? 226 ARG A CD  1 
ATOM   1749 N NE  A ARG A 1 226 ? 23.01254  -5.19451  39.73174  0.377 13.67545 ? 226 ARG A NE  1 
ATOM   1750 N NE  B ARG A 1 226 ? 22.57430  -5.40847  39.76476  0.623 14.16243 ? 226 ARG A NE  1 
ATOM   1751 C CZ  A ARG A 1 226 ? 23.19894  -4.14029  38.94901  0.377 12.97026 ? 226 ARG A CZ  1 
ATOM   1752 C CZ  B ARG A 1 226 ? 21.27623  -5.14056  39.78231  0.623 11.77878 ? 226 ARG A CZ  1 
ATOM   1753 N NH1 A ARG A 1 226 ? 24.33304  -3.94825  38.28894  0.377 6.34217  ? 226 ARG A NH1 1 
ATOM   1754 N NH1 B ARG A 1 226 ? 20.40902  -5.96153  40.35531  0.623 10.17274 ? 226 ARG A NH1 1 
ATOM   1755 N NH2 A ARG A 1 226 ? 22.21923  -3.25039  38.82867  0.377 17.76687 ? 226 ARG A NH2 1 
ATOM   1756 N NH2 B ARG A 1 226 ? 20.83855  -4.01637  39.21753  0.623 12.79078 ? 226 ARG A NH2 1 
ATOM   1757 N N   . ASP A 1 227 ? 24.14187  -6.01867  45.44663  1.000 6.29410  ? 227 ASP A N   1 
ATOM   1758 C CA  . ASP A 1 227 ? 23.20875  -5.66993  46.51734  1.000 8.16391  ? 227 ASP A CA  1 
ATOM   1759 C C   . ASP A 1 227 ? 22.28700  -4.54535  46.06997  1.000 6.50347  ? 227 ASP A C   1 
ATOM   1760 O O   . ASP A 1 227 ? 22.76591  -3.48558  45.65726  1.000 6.56716  ? 227 ASP A O   1 
ATOM   1761 C CB  . ASP A 1 227 ? 23.94360  -5.22111  47.77245  1.000 6.92366  ? 227 ASP A CB  1 
ATOM   1762 C CG  . ASP A 1 227 ? 24.73732  -6.34997  48.43629  1.000 12.75832 ? 227 ASP A CG  1 
ATOM   1763 O OD1 . ASP A 1 227 ? 24.37277  -7.54390  48.29254  1.000 10.12797 ? 227 ASP A OD1 1 
ATOM   1764 O OD2 . ASP A 1 227 ? 25.71366  -6.02513  49.12697  1.000 9.62939  ? 227 ASP A OD2 1 
ATOM   1765 N N   . VAL A 1 228 ? 20.97066  -4.76795  46.15028  1.000 8.04449  ? 228 VAL A N   1 
ATOM   1766 C CA  . VAL A 1 228 ? 20.00788  -3.72331  45.80921  1.000 3.93933  ? 228 VAL A CA  1 
ATOM   1767 C C   . VAL A 1 228 ? 18.92000  -3.63760  46.87022  1.000 8.58722  ? 228 VAL A C   1 
ATOM   1768 O O   . VAL A 1 228 ? 18.60646  -4.61758  47.55874  1.000 5.78619  ? 228 VAL A O   1 
ATOM   1769 C CB  . VAL A 1 228 ? 19.32797  -3.91781  44.42681  1.000 7.01595  ? 228 VAL A CB  1 
ATOM   1770 C CG1 . VAL A 1 228 ? 20.33179  -3.73493  43.27838  1.000 9.19124  ? 228 VAL A CG1 1 
ATOM   1771 C CG2 . VAL A 1 228 ? 18.63165  -5.27045  44.34847  1.000 9.05894  ? 228 VAL A CG2 1 
ATOM   1772 N N   . LEU A 1 229 ? 18.34633  -2.43388  46.96346  1.000 4.50126  ? 229 LEU A N   1 
ATOM   1773 C CA  . LEU A 1 229 ? 17.17061  -2.09597  47.76071  1.000 3.23469  ? 229 LEU A CA  1 
ATOM   1774 C C   . LEU A 1 229 ? 16.08496  -1.76187  46.75552  1.000 3.47448  ? 229 LEU A C   1 
ATOM   1775 O O   . LEU A 1 229 ? 16.29435  -0.90487  45.89580  1.000 4.25829  ? 229 LEU A O   1 
ATOM   1776 C CB  . LEU A 1 229 ? 17.42814  -0.88712  48.65278  1.000 3.04183  ? 229 LEU A CB  1 
ATOM   1777 C CG  . LEU A 1 229 ? 16.23586  -0.38288  49.47950  1.000 6.96277  ? 229 LEU A CG  1 
ATOM   1778 C CD1 . LEU A 1 229 ? 15.78187  -1.41259  50.48079  1.000 5.27172  ? 229 LEU A CD1 1 
ATOM   1779 C CD2 . LEU A 1 229 ? 16.70056  0.88050   50.16307  1.000 8.57561  ? 229 LEU A CD2 1 
ATOM   1780 N N   . ILE A 1 230 ? 14.97930  -2.49131  46.80091  1.000 2.93503  ? 230 ILE A N   1 
ATOM   1781 C CA  . ILE A 1 230 ? 13.88011  -2.30147  45.85551  1.000 3.93049  ? 230 ILE A CA  1 
ATOM   1782 C C   . ILE A 1 230 ? 12.67132  -1.92059  46.67945  1.000 8.70862  ? 230 ILE A C   1 
ATOM   1783 O O   . ILE A 1 230 ? 12.40547  -2.55855  47.70052  1.000 7.63690  ? 230 ILE A O   1 
ATOM   1784 C CB  . ILE A 1 230 ? 13.59954  -3.57400  45.03205  1.000 5.38874  ? 230 ILE A CB  1 
ATOM   1785 C CG1 . ILE A 1 230 ? 14.88035  -3.97500  44.28776  1.000 8.32787  ? 230 ILE A CG1 1 
ATOM   1786 C CG2 . ILE A 1 230 ? 12.35672  -3.37974  44.06752  1.000 7.98742  ? 230 ILE A CG2 1 
ATOM   1787 C CD1 . ILE A 1 230 ? 14.70040  -5.00630  43.17740  1.000 17.59400 ? 230 ILE A CD1 1 
ATOM   1788 N N   . MET A 1 231 ? 11.95875  -0.87178  46.25814  1.000 6.62140  ? 231 MET A N   1 
ATOM   1789 C CA  . MET A 1 231 ? 10.71543  -0.50964  46.92141  1.000 7.15243  ? 231 MET A CA  1 
ATOM   1790 C C   . MET A 1 231 ? 9.61039   -0.40269  45.88031  1.000 14.09426 ? 231 MET A C   1 
ATOM   1791 O O   . MET A 1 231 ? 9.81532   0.12488   44.77884  1.000 9.12351  ? 231 MET A O   1 
ATOM   1792 C CB  . MET A 1 231 ? 10.85357  0.80512   47.74168  1.000 8.71725  ? 231 MET A CB  1 
ATOM   1793 C CG  . MET A 1 231 ? 11.62043  0.58429   49.08981  1.000 9.23733  ? 231 MET A CG  1 
ATOM   1794 S SD  . MET A 1 231 ? 11.72772  2.02272   50.14015  1.000 13.88324 ? 231 MET A SD  1 
ATOM   1795 C CE  . MET A 1 231 ? 12.86305  3.02851   49.20362  1.000 11.18483 ? 231 MET A CE  1 
ATOM   1796 N N   . GLY A 1 232 ? 8.45232   -0.94857  46.21939  1.000 8.59116  ? 232 GLY A N   1 
ATOM   1797 C CA  . GLY A 1 232 ? 7.33790   -0.92101  45.29225  1.000 6.13808  ? 232 GLY A CA  1 
ATOM   1798 C C   . GLY A 1 232 ? 6.14126   -0.26680  45.95744  1.000 10.10318 ? 232 GLY A C   1 
ATOM   1799 O O   . GLY A 1 232 ? 5.71580   -0.69611  47.03180  1.000 8.65066  ? 232 GLY A O   1 
ATOM   1800 N N   . TYR A 1 233 ? 5.59593   0.76848   45.32323  1.000 11.86111 ? 233 TYR A N   1 
ATOM   1801 C CA  . TYR A 1 233 ? 4.57015   1.62285   45.91964  1.000 7.68219  ? 233 TYR A CA  1 
ATOM   1802 C C   . TYR A 1 233 ? 3.24738   1.31076   45.23129  1.000 11.52494 ? 233 TYR A C   1 
ATOM   1803 O O   . TYR A 1 233 ? 3.16085   1.37964   44.00116  1.000 10.59033 ? 233 TYR A O   1 
ATOM   1804 C CB  . TYR A 1 233 ? 4.90742   3.10760   45.74067  1.000 7.67437  ? 233 TYR A CB  1 
ATOM   1805 C CG  . TYR A 1 233 ? 6.17965   3.63291   46.41080  1.000 9.92352  ? 233 TYR A CG  1 
ATOM   1806 C CD1 . TYR A 1 233 ? 7.44662   3.32373   45.90869  1.000 7.39899  ? 233 TYR A CD1 1 
ATOM   1807 C CD2 . TYR A 1 233 ? 6.10439   4.47584   47.51546  1.000 12.75123 ? 233 TYR A CD2 1 
ATOM   1808 C CE1 . TYR A 1 233 ? 8.60750   3.82668   46.50937  1.000 7.08348  ? 233 TYR A CE1 1 
ATOM   1809 C CE2 . TYR A 1 233 ? 7.26687   4.97670   48.13813  1.000 10.32392 ? 233 TYR A CE2 1 
ATOM   1810 C CZ  . TYR A 1 233 ? 8.50732   4.66120   47.62152  1.000 10.92013 ? 233 TYR A CZ  1 
ATOM   1811 O OH  . TYR A 1 233 ? 9.64791   5.16714   48.22336  1.000 12.11834 ? 233 TYR A OH  1 
ATOM   1812 N N   . LYS A 1 234 ? 2.22951   0.96299   46.01866  1.000 13.92476 ? 234 LYS A N   1 
ATOM   1813 C CA  . LYS A 1 234 ? 0.91268   0.60902   45.50641  1.000 10.89266 ? 234 LYS A CA  1 
ATOM   1814 C C   . LYS A 1 234 ? -0.14023  1.43819   46.23627  1.000 13.78122 ? 234 LYS A C   1 
ATOM   1815 O O   . LYS A 1 234 ? -0.29276  1.31525   47.45391  1.000 15.78500 ? 234 LYS A O   1 
ATOM   1816 C CB  . LYS A 1 234 ? 0.61106   -0.88336  45.69132  1.000 10.83554 ? 234 LYS A CB  1 
ATOM   1817 C CG  . LYS A 1 234 ? -0.56906  -1.34694  44.79267  1.000 23.25000 ? 234 LYS A CG  1 
ATOM   1818 C CD  . LYS A 1 234 ? -0.89639  -2.82218  44.96975  1.000 24.38665 ? 234 LYS A CD  1 
ATOM   1819 C CE  . LYS A 1 234 ? -1.92026  -3.27795  43.95206  1.000 41.83125 ? 234 LYS A CE  1 
ATOM   1820 N NZ  . LYS A 1 234 ? -3.02587  -2.29351  43.78993  1.000 30.06553 ? 234 LYS A NZ  1 
ATOM   1821 N N   . HIS A 1 235 ? -0.83486  2.28292   45.49149  1.000 17.91474 ? 235 HIS A N   1 
ATOM   1822 C CA  . HIS A 1 235 ? -2.00763  3.01550   45.97813  1.000 25.74437 ? 235 HIS A CA  1 
ATOM   1823 C C   . HIS A 1 235 ? -3.06016  2.06672   46.54545  1.000 24.23570 ? 235 HIS A C   1 
ATOM   1824 O O   . HIS A 1 235 ? -3.53080  1.16449   45.84426  1.000 17.78533 ? 235 HIS A O   1 
ATOM   1825 C CB  . HIS A 1 235 ? -2.58554  3.82250   44.81476  1.000 23.58888 ? 235 HIS A CB  1 
ATOM   1826 C CG  . HIS A 1 235 ? -3.74378  4.69644   45.19150  1.000 26.52633 ? 235 HIS A CG  1 
ATOM   1827 N ND1 . HIS A 1 235 ? -4.91099  4.74388   44.45726  1.000 25.19618 ? 235 HIS A ND1 1 
ATOM   1828 C CD2 . HIS A 1 235 ? -3.91165  5.55723   46.22248  1.000 24.27748 ? 235 HIS A CD2 1 
ATOM   1829 C CE1 . HIS A 1 235 ? -5.75034  5.59193   45.02590  1.000 34.17905 ? 235 HIS A CE1 1 
ATOM   1830 N NE2 . HIS A 1 235 ? -5.16792  6.10038   46.09845  1.000 30.25916 ? 235 HIS A NE2 1 
ATOM   1831 N N   . GLU A 1 236 ? -3.44569  2.27146   47.81492  1.000 23.75592 ? 236 GLU A N   1 
ATOM   1832 C CA  . GLU A 1 236 ? -4.42018  1.40435   48.49393  1.000 28.97125 ? 236 GLU A CA  1 
ATOM   1833 C C   . GLU A 1 236 ? -5.38778  2.23289   49.34205  1.000 32.03069 ? 236 GLU A C   1 
ATOM   1834 O O   . GLU A 1 236 ? -5.22425  2.35697   50.56224  1.000 22.28338 ? 236 GLU A O   1 
ATOM   1835 C CB  . GLU A 1 236 ? -3.72103  0.36512   49.37728  1.000 24.95473 ? 236 GLU A CB  1 
ATOM   1836 C CG  . GLU A 1 236 ? -2.86650  -0.67267  48.66791  1.000 33.15462 ? 236 GLU A CG  1 
ATOM   1837 C CD  . GLU A 1 236 ? -3.69061  -1.73142  47.98597  1.000 44.82711 ? 236 GLU A CD  1 
ATOM   1838 O OE1 . GLU A 1 236 ? -4.93535  -1.70557  48.14707  1.000 39.85520 ? 236 GLU A OE1 1 
ATOM   1839 O OE2 . GLU A 1 236 ? -3.09401  -2.58763  47.29033  1.000 34.21756 ? 236 GLU A OE2 1 
ATOM   1840 N N   . PRO A 1 237 ? -6.43932  2.78931   48.72923  1.000 37.33324 ? 237 PRO A N   1 
ATOM   1841 C CA  . PRO A 1 237 ? -7.29898  3.74389   49.46099  1.000 36.57239 ? 237 PRO A CA  1 
ATOM   1842 C C   . PRO A 1 237 ? -8.03477  3.13677   50.64432  1.000 34.00280 ? 237 PRO A C   1 
ATOM   1843 O O   . PRO A 1 237 ? -8.52395  3.88883   51.49726  1.000 34.78135 ? 237 PRO A O   1 
ATOM   1844 C CB  . PRO A 1 237 ? -8.29200  4.23618   48.39110  1.000 26.88426 ? 237 PRO A CB  1 
ATOM   1845 C CG  . PRO A 1 237 ? -7.96662  3.50812   47.13084  1.000 33.61835 ? 237 PRO A CG  1 
ATOM   1846 C CD  . PRO A 1 237 ? -7.03189  2.37486   47.44771  1.000 33.26333 ? 237 PRO A CD  1 
ATOM   1847 N N   . GLU A 1 238 ? -8.11798  1.81428   50.73382  1.000 29.15424 ? 238 GLU A N   1 
ATOM   1848 C CA  . GLU A 1 238 ? -8.88315  1.15313   51.77571  1.000 36.34267 ? 238 GLU A CA  1 
ATOM   1849 C C   . GLU A 1 238 ? -8.00679  0.49937   52.83342  1.000 41.57332 ? 238 GLU A C   1 
ATOM   1850 O O   . GLU A 1 238 ? -8.53721  -0.10196  53.77725  1.000 34.14586 ? 238 GLU A O   1 
ATOM   1851 C CB  . GLU A 1 238 ? -9.81572  0.10706   51.14983  1.000 41.57254 ? 238 GLU A CB  1 
ATOM   1852 C CG  . GLU A 1 238 ? -10.52497 0.58854   49.87784  1.000 43.76549 ? 238 GLU A CG  1 
ATOM   1853 C CD  . GLU A 1 238 ? -11.47206 1.75715   50.12328  1.000 51.89533 ? 238 GLU A CD  1 
ATOM   1854 O OE1 . GLU A 1 238 ? -11.91921 1.93560   51.27871  1.000 55.49630 ? 238 GLU A OE1 1 
ATOM   1855 O OE2 . GLU A 1 238 ? -11.77328 2.49967   49.15761  1.000 58.09618 ? 238 GLU A OE2 1 
ATOM   1856 N N   . LEU A 1 239 ? -6.68452  0.59390   52.70589  1.000 24.55147 ? 239 LEU A N   1 
ATOM   1857 C CA  . LEU A 1 239 ? -5.80497  0.04696   53.72656  1.000 27.21480 ? 239 LEU A CA  1 
ATOM   1858 C C   . LEU A 1 239 ? -5.89744  0.89515   54.98877  1.000 24.72472 ? 239 LEU A C   1 
ATOM   1859 O O   . LEU A 1 239 ? -5.74633  2.11874   54.94017  1.000 33.04641 ? 239 LEU A O   1 
ATOM   1860 C CB  . LEU A 1 239 ? -4.36263  0.01064   53.22086  1.000 30.38950 ? 239 LEU A CB  1 
ATOM   1861 C CG  . LEU A 1 239 ? -3.29011  -0.42008  54.21884  1.000 23.99511 ? 239 LEU A CG  1 
ATOM   1862 C CD1 . LEU A 1 239 ? -3.36810  -1.91558  54.47179  1.000 27.77512 ? 239 LEU A CD1 1 
ATOM   1863 C CD2 . LEU A 1 239 ? -1.91056  -0.02333  53.71652  1.000 23.43260 ? 239 LEU A CD2 1 
ATOM   1864 N N   . ARG A 1 240 ? -6.14604  0.25632   56.12001  1.000 29.24616 ? 240 ARG A N   1 
ATOM   1865 C CA  . ARG A 1 240 ? -6.24084  0.98310   57.37527  1.000 39.65934 ? 240 ARG A CA  1 
ATOM   1866 C C   . ARG A 1 240 ? -5.02547  0.68476   58.24342  1.000 38.04760 ? 240 ARG A C   1 
ATOM   1867 O O   . ARG A 1 240 ? -4.31272  -0.30089  58.03641  1.000 31.20782 ? 240 ARG A O   1 
ATOM   1868 C CB  . ARG A 1 240 ? -7.53701  0.63560   58.11824  1.000 43.42058 ? 240 ARG A CB  1 
ATOM   1869 C CG  . ARG A 1 240 ? -8.80501  1.17760   57.44332  1.000 51.28475 ? 240 ARG A CG  1 
ATOM   1870 C CD  . ARG A 1 240 ? -8.96550  2.69284   57.66813  1.000 57.60482 ? 240 ARG A CD  1 
ATOM   1871 N NE  . ARG A 1 240 ? -9.60193  3.00414   58.94654  1.000 68.61844 ? 240 ARG A NE  1 
ATOM   1872 C CZ  . ARG A 1 240 ? -9.65305  4.21814   59.48249  1.000 72.66957 ? 240 ARG A CZ  1 
ATOM   1873 N NH1 . ARG A 1 240 ? -9.10541  5.26099   58.88405  1.000 74.55026 ? 240 ARG A NH1 1 
ATOM   1874 N NH2 . ARG A 1 240 ? -10.26583 4.39212   60.64951  1.000 70.37839 ? 240 ARG A NH2 1 
ATOM   1875 N N   . ARG A 1 241 ? -4.78530  1.56569   59.21081  1.000 35.16899 ? 241 ARG A N   1 
ATOM   1876 C CA  . ARG A 1 241 ? -3.66505  1.37596   60.11934  1.000 33.00998 ? 241 ARG A CA  1 
ATOM   1877 C C   . ARG A 1 241 ? -3.78294  0.03734   60.83770  1.000 32.68719 ? 241 ARG A C   1 
ATOM   1878 O O   . ARG A 1 241 ? -4.87909  -0.46225  61.10246  1.000 37.67416 ? 241 ARG A O   1 
ATOM   1879 C CB  . ARG A 1 241 ? -3.59683  2.52129   61.13030  1.000 31.91212 ? 241 ARG A CB  1 
ATOM   1880 C CG  . ARG A 1 241 ? -3.52924  3.89213   60.47638  1.000 30.21611 ? 241 ARG A CG  1 
ATOM   1881 C CD  . ARG A 1 241 ? -2.93962  4.97119   61.39010  1.000 23.70979 ? 241 ARG A CD  1 
ATOM   1882 N NE  . ARG A 1 241 ? -2.56535  6.13821   60.60141  1.000 31.82046 ? 241 ARG A NE  1 
ATOM   1883 C CZ  . ARG A 1 241 ? -3.36613  7.16454   60.35154  1.000 30.49368 ? 241 ARG A CZ  1 
ATOM   1884 N NH1 . ARG A 1 241 ? -4.56378  7.25655   60.89998  1.000 40.91598 ? 241 ARG A NH1 1 
ATOM   1885 N NH2 . ARG A 1 241 ? -2.95709  8.12144   59.52633  1.000 37.86516 ? 241 ARG A NH2 1 
ATOM   1886 N N   . GLU A 1 242 ? -2.63526  -0.56350  61.11749  1.000 29.25936 ? 242 GLU A N   1 
ATOM   1887 C CA  . GLU A 1 242 ? -2.55654  -1.81878  61.84476  1.000 33.29785 ? 242 GLU A CA  1 
ATOM   1888 C C   . GLU A 1 242 ? -1.64680  -1.61363  63.04606  1.000 29.38272 ? 242 GLU A C   1 
ATOM   1889 O O   . GLU A 1 242 ? -0.95461  -0.59409  63.15359  1.000 31.79956 ? 242 GLU A O   1 
ATOM   1890 C CB  . GLU A 1 242 ? -2.03981  -2.95264  60.94617  1.000 25.51572 ? 242 GLU A CB  1 
ATOM   1891 C CG  . GLU A 1 242 ? -2.92885  -3.20031  59.73986  1.000 27.53739 ? 242 GLU A CG  1 
ATOM   1892 C CD  . GLU A 1 242 ? -2.16342  -3.68356  58.50963  1.000 37.07222 ? 242 GLU A CD  1 
ATOM   1893 O OE1 . GLU A 1 242 ? -1.10248  -3.10029  58.16830  1.000 26.92197 ? 242 GLU A OE1 1 
ATOM   1894 O OE2 . GLU A 1 242 ? -2.64514  -4.64025  57.87063  1.000 38.90044 ? 242 GLU A OE2 1 
ATOM   1895 N N   . GLU A 1 243 ? -1.66893  -2.59107  63.95450  1.000 25.69115 ? 243 GLU A N   1 
ATOM   1896 C CA  . GLU A 1 243 ? -0.83837  -2.54145  65.15205  1.000 36.59531 ? 243 GLU A CA  1 
ATOM   1897 C C   . GLU A 1 243 ? 0.63698   -2.46903  64.77220  1.000 42.27810 ? 243 GLU A C   1 
ATOM   1898 O O   . GLU A 1 243 ? 1.07039   -3.06498  63.78326  1.000 45.21194 ? 243 GLU A O   1 
ATOM   1899 C CB  . GLU A 1 243 ? -1.10414  -3.76791  66.02796  1.000 38.03649 ? 243 GLU A CB  1 
ATOM   1900 C CG  . GLU A 1 243 ? -0.12414  -3.95873  67.18391  1.000 54.28302 ? 243 GLU A CG  1 
ATOM   1901 C CD  . GLU A 1 243 ? -0.12205  -5.38255  67.73869  1.000 67.97668 ? 243 GLU A CD  1 
ATOM   1902 O OE1 . GLU A 1 243 ? -1.20887  -5.88771  68.09487  1.000 71.28546 ? 243 GLU A OE1 1 
ATOM   1903 O OE2 . GLU A 1 243 ? 0.96762   -6.00349  67.81014  1.000 67.13609 ? 243 GLU A OE2 1 
ATOM   1904 N N   . GLN A 1 244 ? 1.40928   -1.72967  65.56343  1.000 39.56457 ? 244 GLN A N   1 
ATOM   1905 C CA  . GLN A 1 244 ? 2.82459   -1.52464  65.27779  1.000 47.07737 ? 244 GLN A CA  1 
ATOM   1906 C C   . GLN A 1 244 ? 3.66629   -1.75421  66.52867  1.000 47.35932 ? 244 GLN A C   1 
ATOM   1907 O O   . GLN A 1 244 ? 3.89620   -2.89366  66.93827  1.000 49.55118 ? 244 GLN A O   1 
ATOM   1908 C CB  . GLN A 1 244 ? 3.05528   -0.10769  64.72377  1.000 41.55602 ? 244 GLN A CB  1 
ATOM   1909 C CG  . GLN A 1 244 ? 4.37863   0.08515   63.97851  1.000 38.44871 ? 244 GLN A CG  1 
ATOM   1910 C CD  . GLN A 1 244 ? 4.50510   1.46859   63.33719  1.000 38.97091 ? 244 GLN A CD  1 
ATOM   1911 O OE1 . GLN A 1 244 ? 5.45209   1.72853   62.58936  1.000 23.41044 ? 244 GLN A OE1 1 
ATOM   1912 N NE2 . GLN A 1 244 ? 3.55094   2.36241   63.63305  1.000 28.34271 ? 244 GLN A NE2 1 
ATOM   1913 N N   . THR B 1 3   ? 44.72214  5.35072   31.41637  1.000 62.45697 ? 3   THR B N   1 
ATOM   1914 C CA  . THR B 1 3   ? 45.04480  4.03875   30.86958  1.000 56.89028 ? 3   THR B CA  1 
ATOM   1915 C C   . THR B 1 3   ? 45.77439  4.16371   29.52745  1.000 55.32073 ? 3   THR B C   1 
ATOM   1916 O O   . THR B 1 3   ? 45.89868  5.26403   28.98150  1.000 53.38369 ? 3   THR B O   1 
ATOM   1917 C CB  . THR B 1 3   ? 43.77957  3.17491   30.70240  1.000 53.70281 ? 3   THR B CB  1 
ATOM   1918 O OG1 . THR B 1 3   ? 44.09229  2.00520   29.93416  1.000 69.28239 ? 3   THR B OG1 1 
ATOM   1919 C CG2 . THR B 1 3   ? 42.67284  3.96054   30.01490  1.000 49.78270 ? 3   THR B CG2 1 
ATOM   1920 N N   . GLU B 1 4   ? 46.25272  3.02621   29.00762  1.000 57.92947 ? 4   GLU B N   1 
ATOM   1921 C CA  . GLU B 1 4   ? 47.15081  3.03953   27.85437  1.000 48.02807 ? 4   GLU B CA  1 
ATOM   1922 C C   . GLU B 1 4   ? 46.42033  3.44198   26.57747  1.000 48.83777 ? 4   GLU B C   1 
ATOM   1923 O O   . GLU B 1 4   ? 46.87816  4.32731   25.84476  1.000 42.06978 ? 4   GLU B O   1 
ATOM   1924 C CB  . GLU B 1 4   ? 47.81283  1.66887   27.68622  1.000 51.78857 ? 4   GLU B CB  1 
ATOM   1925 C CG  . GLU B 1 4   ? 48.53736  1.48523   26.35063  1.000 54.91741 ? 4   GLU B CG  1 
ATOM   1926 C CD  . GLU B 1 4   ? 49.96846  2.02566   26.35573  1.000 70.77303 ? 4   GLU B CD  1 
ATOM   1927 O OE1 . GLU B 1 4   ? 50.82427  1.44072   27.05836  1.000 66.21763 ? 4   GLU B OE1 1 
ATOM   1928 O OE2 . GLU B 1 4   ? 50.24037  3.03273   25.65823  1.000 56.28890 ? 4   GLU B OE2 1 
ATOM   1929 N N   . ALA B 1 5   ? 45.28735  2.79525   26.28424  1.000 46.50370 ? 5   ALA B N   1 
ATOM   1930 C CA  . ALA B 1 5   ? 44.56207  3.11438   25.05692  1.000 38.97509 ? 5   ALA B CA  1 
ATOM   1931 C C   . ALA B 1 5   ? 44.14320  4.57998   25.02205  1.000 39.64856 ? 5   ALA B C   1 
ATOM   1932 O O   . ALA B 1 5   ? 44.19820  5.22295   23.96317  1.000 30.76584 ? 5   ALA B O   1 
ATOM   1933 C CB  . ALA B 1 5   ? 43.34664  2.20164   24.90333  1.000 35.40331 ? 5   ALA B CB  1 
ATOM   1934 N N   . ARG B 1 6   ? 43.73631  5.13371   26.16919  1.000 41.37080 ? 6   ARG B N   1 
ATOM   1935 C CA  . ARG B 1 6   ? 43.36857  6.54820   26.22417  1.000 37.91462 ? 6   ARG B CA  1 
ATOM   1936 C C   . ARG B 1 6   ? 44.51378  7.42974   25.75206  1.000 32.20594 ? 6   ARG B C   1 
ATOM   1937 O O   . ARG B 1 6   ? 44.36509  8.22742   24.81839  1.000 36.55836 ? 6   ARG B O   1 
ATOM   1938 C CB  . ARG B 1 6   ? 42.96193  6.95259   27.64654  1.000 38.85381 ? 6   ARG B CB  1 
ATOM   1939 C CG  . ARG B 1 6   ? 41.49294  6.76863   27.96930  1.000 35.84666 ? 6   ARG B CG  1 
ATOM   1940 C CD  . ARG B 1 6   ? 41.00098  7.83899   28.94141  1.000 42.39694 ? 6   ARG B CD  1 
ATOM   1941 N NE  . ARG B 1 6   ? 39.61424  7.60114   29.32354  1.000 49.38442 ? 6   ARG B NE  1 
ATOM   1942 C CZ  . ARG B 1 6   ? 39.24580  6.94431   30.41640  1.000 52.58567 ? 6   ARG B CZ  1 
ATOM   1943 N NH1 . ARG B 1 6   ? 40.13096  6.56283   31.32473  1.000 52.63543 ? 6   ARG B NH1 1 
ATOM   1944 N NH2 . ARG B 1 6   ? 37.96123  6.64534   30.59347  1.000 36.17653 ? 6   ARG B NH2 1 
ATOM   1945 N N   . GLU B 1 7   ? 45.66903  7.30922   26.41040  1.000 39.57026 ? 7   GLU B N   1 
ATOM   1946 C CA  . GLU B 1 7   ? 46.79145  8.17709   26.07338  1.000 42.40142 ? 7   GLU B CA  1 
ATOM   1947 C C   . GLU B 1 7   ? 47.30951  7.88260   24.67072  1.000 35.11067 ? 7   GLU B C   1 
ATOM   1948 O O   . GLU B 1 7   ? 47.65834  8.80980   23.92731  1.000 38.88409 ? 7   GLU B O   1 
ATOM   1949 C CB  . GLU B 1 7   ? 47.89496  8.03864   27.12256  1.000 48.90699 ? 7   GLU B CB  1 
ATOM   1950 C CG  . GLU B 1 7   ? 48.29595  6.61189   27.44720  1.000 53.66630 ? 7   GLU B CG  1 
ATOM   1951 C CD  . GLU B 1 7   ? 49.35042  6.53476   28.53870  1.000 61.92350 ? 7   GLU B CD  1 
ATOM   1952 O OE1 . GLU B 1 7   ? 49.56794  7.55479   29.23168  1.000 61.48912 ? 7   GLU B OE1 1 
ATOM   1953 O OE2 . GLU B 1 7   ? 49.96244  5.45361   28.70103  1.000 63.98544 ? 7   GLU B OE2 1 
ATOM   1954 N N   . GLU B 1 8   ? 47.33368  6.60360   24.27918  1.000 34.70177 ? 8   GLU B N   1 
ATOM   1955 C CA  . GLU B 1 8   ? 47.62751  6.25786   22.89093  1.000 36.86641 ? 8   GLU B CA  1 
ATOM   1956 C C   . GLU B 1 8   ? 46.68759  6.98254   21.94006  1.000 36.35733 ? 8   GLU B C   1 
ATOM   1957 O O   . GLU B 1 8   ? 47.11649  7.54104   20.92405  1.000 33.20160 ? 8   GLU B O   1 
ATOM   1958 C CB  . GLU B 1 8   ? 47.51760  4.75136   22.68024  1.000 38.01764 ? 8   GLU B CB  1 
ATOM   1959 C CG  . GLU B 1 8   ? 48.76100  3.98834   23.02100  1.000 46.49548 ? 8   GLU B CG  1 
ATOM   1960 C CD  . GLU B 1 8   ? 48.65520  2.53694   22.61984  1.000 51.37375 ? 8   GLU B CD  1 
ATOM   1961 O OE1 . GLU B 1 8   ? 47.87221  2.23781   21.69337  1.000 44.06918 ? 8   GLU B OE1 1 
ATOM   1962 O OE2 . GLU B 1 8   ? 49.34300  1.69207   23.23284  1.000 61.06874 ? 8   GLU B OE2 1 
ATOM   1963 N N   . LEU B 1 9   ? 45.38998  6.98135   22.25633  1.000 32.98507 ? 9   LEU B N   1 
ATOM   1964 C CA  . LEU B 1 9   ? 44.45057  7.75787   21.45961  1.000 31.23072 ? 9   LEU B CA  1 
ATOM   1965 C C   . LEU B 1 9   ? 44.71520  9.24311   21.61258  1.000 31.21311 ? 9   LEU B C   1 
ATOM   1966 O O   . LEU B 1 9   ? 44.64534  9.99517   20.63437  1.000 33.65944 ? 9   LEU B O   1 
ATOM   1967 C CB  . LEU B 1 9   ? 43.00737  7.43700   21.85642  1.000 34.17461 ? 9   LEU B CB  1 
ATOM   1968 C CG  . LEU B 1 9   ? 42.14037  6.95652   20.69268  1.000 33.25995 ? 9   LEU B CG  1 
ATOM   1969 C CD1 . LEU B 1 9   ? 42.60812  5.59065   20.32023  1.000 32.69170 ? 9   LEU B CD1 1 
ATOM   1970 C CD2 . LEU B 1 9   ? 40.66297  6.93139   21.04693  1.000 33.40265 ? 9   LEU B CD2 1 
ATOM   1971 N N   . ARG B 1 10  ? 45.00349  9.68698   22.83935  1.000 38.96546 ? 10  ARG B N   1 
ATOM   1972 C CA  . ARG B 1 10  ? 45.27853  11.10221  23.05429  1.000 37.39919 ? 10  ARG B CA  1 
ATOM   1973 C C   . ARG B 1 10  ? 46.50065  11.54241  22.25971  1.000 40.45552 ? 10  ARG B C   1 
ATOM   1974 O O   . ARG B 1 10  ? 46.47685  12.58111  21.58605  1.000 37.33998 ? 10  ARG B O   1 
ATOM   1975 C CB  . ARG B 1 10  ? 45.47755  11.37071  24.54416  1.000 40.02895 ? 10  ARG B CB  1 
ATOM   1976 C CG  . ARG B 1 10  ? 45.12324  12.77852  24.97382  1.000 41.82062 ? 10  ARG B CG  1 
ATOM   1977 C CD  . ARG B 1 10  ? 45.71750  13.09833  26.33973  1.000 48.09154 ? 10  ARG B CD  1 
ATOM   1978 N NE  . ARG B 1 10  ? 47.06727  12.56226  26.48850  1.000 52.63749 ? 10  ARG B NE  1 
ATOM   1979 C CZ  . ARG B 1 10  ? 48.15753  13.09024  25.94085  1.000 58.33844 ? 10  ARG B CZ  1 
ATOM   1980 N NH1 . ARG B 1 10  ? 48.09903  14.17279  25.17593  1.000 46.78350 ? 10  ARG B NH1 1 
ATOM   1981 N NH2 . ARG B 1 10  ? 49.33735  12.51375  26.15927  1.000 53.98919 ? 10  ARG B NH2 1 
ATOM   1982 N N   . ALA B 1 11  ? 47.56422  10.73819  22.29068  1.000 35.08806 ? 11  ALA B N   1 
ATOM   1983 C CA  . ALA B 1 11  ? 48.81371  11.12670  21.65080  1.000 37.20271 ? 11  ALA B CA  1 
ATOM   1984 C C   . ALA B 1 11  ? 48.77914  10.92613  20.13759  1.000 45.60218 ? 11  ALA B C   1 
ATOM   1985 O O   . ALA B 1 11  ? 49.23301  11.79852  19.38968  1.000 43.73198 ? 11  ALA B O   1 
ATOM   1986 C CB  . ALA B 1 11  ? 49.97409  10.34252  22.26371  1.000 42.09407 ? 11  ALA B CB  1 
ATOM   1987 N N   . ASN B 1 12  ? 48.26546  9.78720   19.66146  1.000 35.66715 ? 12  ASN B N   1 
ATOM   1988 C CA  . ASN B 1 12  ? 48.41873  9.41322   18.26061  1.000 31.73793 ? 12  ASN B CA  1 
ATOM   1989 C C   . ASN B 1 12  ? 47.11835  9.33881   17.47132  1.000 31.83302 ? 12  ASN B C   1 
ATOM   1990 O O   . ASN B 1 12  ? 47.17668  9.20648   16.24354  1.000 31.51158 ? 12  ASN B O   1 
ATOM   1991 C CB  . ASN B 1 12  ? 49.13716  8.06085   18.14874  1.000 35.29286 ? 12  ASN B CB  1 
ATOM   1992 C CG  . ASN B 1 12  ? 50.38231  7.99673   18.99781  1.000 36.69890 ? 12  ASN B CG  1 
ATOM   1993 O OD1 . ASN B 1 12  ? 50.56299  7.06952   19.78327  1.000 46.51268 ? 12  ASN B OD1 1 
ATOM   1994 N ND2 . ASN B 1 12  ? 51.24417  8.98874   18.85293  1.000 33.31068 ? 12  ASN B ND2 1 
ATOM   1995 N N   . GLY B 1 13  ? 45.95691  9.42162   18.12071  1.000 28.06031 ? 13  GLY B N   1 
ATOM   1996 C CA  . GLY B 1 13  ? 44.69216  9.43897   17.41304  1.000 30.21948 ? 13  GLY B CA  1 
ATOM   1997 C C   . GLY B 1 13  ? 44.12639  8.07662   17.08361  1.000 20.68596 ? 13  GLY B C   1 
ATOM   1998 O O   . GLY B 1 13  ? 43.04254  7.99763   16.49612  1.000 20.86979 ? 13  GLY B O   1 
ATOM   1999 N N   . TYR B 1 14  ? 44.83040  7.00900   17.43335  1.000 20.11031 ? 14  TYR B N   1 
ATOM   2000 C CA  . TYR B 1 14  ? 44.38178  5.65269   17.19472  1.000 23.19472 ? 14  TYR B CA  1 
ATOM   2001 C C   . TYR B 1 14  ? 45.13968  4.76400   18.16293  1.000 28.44224 ? 14  TYR B C   1 
ATOM   2002 O O   . TYR B 1 14  ? 46.23096  5.10543   18.62645  1.000 22.44730 ? 14  TYR B O   1 
ATOM   2003 C CB  . TYR B 1 14  ? 44.61146  5.21715   15.73720  1.000 24.57052 ? 14  TYR B CB  1 
ATOM   2004 C CG  . TYR B 1 14  ? 46.04787  4.87077   15.45309  1.000 27.00757 ? 14  TYR B CG  1 
ATOM   2005 C CD1 . TYR B 1 14  ? 46.96968  5.86232   15.12499  1.000 27.15257 ? 14  TYR B CD1 1 
ATOM   2006 C CD2 . TYR B 1 14  ? 46.49411  3.55248   15.53815  1.000 29.83147 ? 14  TYR B CD2 1 
ATOM   2007 C CE1 . TYR B 1 14  ? 48.29814  5.54936   14.87475  1.000 28.76038 ? 14  TYR B CE1 1 
ATOM   2008 C CE2 . TYR B 1 14  ? 47.81994  3.23184   15.29965  1.000 36.35925 ? 14  TYR B CE2 1 
ATOM   2009 C CZ  . TYR B 1 14  ? 48.71753  4.23422   14.96876  1.000 32.17713 ? 14  TYR B CZ  1 
ATOM   2010 O OH  . TYR B 1 14  ? 50.03501  3.90981   14.73209  1.000 45.35989 ? 14  TYR B OH  1 
ATOM   2011 N N   . SER B 1 15  ? 44.54141  3.62265   18.47238  1.000 23.07868 ? 15  SER B N   1 
ATOM   2012 C CA  . SER B 1 15  ? 45.17521  2.64363   19.33598  1.000 25.41474 ? 15  SER B CA  1 
ATOM   2013 C C   . SER B 1 15  ? 44.77424  1.27055   18.83330  1.000 35.69281 ? 15  SER B C   1 
ATOM   2014 O O   . SER B 1 15  ? 43.64243  1.08557   18.36907  1.000 30.76910 ? 15  SER B O   1 
ATOM   2015 C CB  . SER B 1 15  ? 44.76059  2.83117   20.80291  1.000 29.75311 ? 15  SER B CB  1 
ATOM   2016 O OG  . SER B 1 15  ? 45.33741  1.84282   21.64238  1.000 47.76289 ? 15  SER B OG  1 
ATOM   2017 N N   . LEU B 1 16  ? 45.70405  0.32119   18.90542  1.000 30.29097 ? 16  LEU B N   1 
ATOM   2018 C CA  . LEU B 1 16  ? 45.41323  -1.06195  18.56363  1.000 27.31363 ? 16  LEU B CA  1 
ATOM   2019 C C   . LEU B 1 16  ? 45.16778  -1.87097  19.82458  1.000 34.34816 ? 16  LEU B C   1 
ATOM   2020 O O   . LEU B 1 16  ? 45.78498  -1.62950  20.86643  1.000 34.13386 ? 16  LEU B O   1 
ATOM   2021 C CB  . LEU B 1 16  ? 46.55395  -1.69870  17.77931  1.000 43.15835 ? 16  LEU B CB  1 
ATOM   2022 C CG  . LEU B 1 16  ? 46.91522  -1.03956  16.46190  1.000 33.96761 ? 16  LEU B CG  1 
ATOM   2023 C CD1 . LEU B 1 16  ? 47.66665  -2.04256  15.59525  1.000 34.04421 ? 16  LEU B CD1 1 
ATOM   2024 C CD2 . LEU B 1 16  ? 45.65460  -0.55372  15.78321  1.000 35.21741 ? 16  LEU B CD2 1 
ATOM   2025 N N   . LEU B 1 17  ? 44.25035  -2.82535  19.72587  1.000 23.49743 ? 17  LEU B N   1 
ATOM   2026 C CA  . LEU B 1 17  ? 44.03164  -3.80697  20.78014  1.000 24.90849 ? 17  LEU B CA  1 
ATOM   2027 C C   . LEU B 1 17  ? 43.90826  -5.14569  20.07302  1.000 30.71788 ? 17  LEU B C   1 
ATOM   2028 O O   . LEU B 1 17  ? 42.82765  -5.51423  19.60091  1.000 23.28578 ? 17  LEU B O   1 
ATOM   2029 C CB  . LEU B 1 17  ? 42.78019  -3.49153  21.59899  1.000 29.01541 ? 17  LEU B CB  1 
ATOM   2030 C CG  . LEU B 1 17  ? 42.67104  -3.90162  23.06726  1.000 42.42004 ? 17  LEU B CG  1 
ATOM   2031 C CD1 . LEU B 1 17  ? 41.34790  -3.37618  23.62584  1.000 31.10565 ? 17  LEU B CD1 1 
ATOM   2032 C CD2 . LEU B 1 17  ? 42.76534  -5.40182  23.26865  1.000 40.63829 ? 17  LEU B CD2 1 
ATOM   2033 N N   . PRO B 1 18  ? 45.01329  -5.88375  19.95052  1.000 27.06192 ? 18  PRO B N   1 
ATOM   2034 C CA  . PRO B 1 18  ? 44.91624  -7.23835  19.39254  1.000 22.08619 ? 18  PRO B CA  1 
ATOM   2035 C C   . PRO B 1 18  ? 44.10317  -8.14533  20.30142  1.000 28.48344 ? 18  PRO B C   1 
ATOM   2036 O O   . PRO B 1 18  ? 43.99549  -7.92698  21.50883  1.000 33.76935 ? 18  PRO B O   1 
ATOM   2037 C CB  . PRO B 1 18  ? 46.37659  -7.69289  19.30030  1.000 32.66543 ? 18  PRO B CB  1 
ATOM   2038 C CG  . PRO B 1 18  ? 47.12239  -6.80351  20.23271  1.000 41.52386 ? 18  PRO B CG  1 
ATOM   2039 C CD  . PRO B 1 18  ? 46.40252  -5.48959  20.22209  1.000 36.74499 ? 18  PRO B CD  1 
ATOM   2040 N N   . ALA B 1 19  ? 43.51332  -9.17374  19.69692  1.000 27.47698 ? 19  ALA B N   1 
ATOM   2041 C CA  . ALA B 1 19  ? 42.69538  -10.10434 20.45993  1.000 24.48047 ? 19  ALA B CA  1 
ATOM   2042 C C   . ALA B 1 19  ? 43.48647  -10.78664 21.57165  1.000 38.01854 ? 19  ALA B C   1 
ATOM   2043 O O   . ALA B 1 19  ? 42.90465  -11.17329 22.59059  1.000 46.46036 ? 19  ALA B O   1 
ATOM   2044 C CB  . ALA B 1 19  ? 42.09691  -11.14574 19.52348  1.000 25.01897 ? 19  ALA B CB  1 
ATOM   2045 N N   . ASP B 1 20  ? 44.80624  -10.94172 21.40089  1.000 46.04643 ? 20  ASP B N   1 
ATOM   2046 C CA  . ASP B 1 20  ? 45.60744  -11.65648 22.39643  1.000 56.77844 ? 20  ASP B CA  1 
ATOM   2047 C C   . ASP B 1 20  ? 45.83383  -10.82973 23.65958  1.000 54.14648 ? 20  ASP B C   1 
ATOM   2048 O O   . ASP B 1 20  ? 45.92698  -11.39356 24.75750  1.000 58.74226 ? 20  ASP B O   1 
ATOM   2049 C CB  . ASP B 1 20  ? 46.94678  -12.08435 21.79210  1.000 49.75487 ? 20  ASP B CB  1 
ATOM   2050 C CG  . ASP B 1 20  ? 47.75655  -10.91383 21.25702  1.000 51.66289 ? 20  ASP B CG  1 
ATOM   2051 O OD1 . ASP B 1 20  ? 48.02301  -9.95535  22.01575  1.000 62.39147 ? 20  ASP B OD1 1 
ATOM   2052 O OD2 . ASP B 1 20  ? 48.15363  -10.96083 20.07544  1.000 54.76380 ? 20  ASP B OD2 1 
ATOM   2053 N N   . ARG B 1 21  ? 45.93143  -9.50247  23.52769  1.000 60.44532 ? 21  ARG B N   1 
ATOM   2054 C CA  . ARG B 1 21  ? 46.07035  -8.60849  24.67594  1.000 57.26644 ? 21  ARG B CA  1 
ATOM   2055 C C   . ARG B 1 21  ? 44.80700  -8.53890  25.52299  1.000 55.53254 ? 21  ARG B C   1 
ATOM   2056 O O   . ARG B 1 21  ? 44.81021  -7.87851  26.56735  1.000 54.80325 ? 21  ARG B O   1 
ATOM   2057 C CB  . ARG B 1 21  ? 46.45647  -7.20554  24.19822  1.000 47.35789 ? 21  ARG B CB  1 
ATOM   2058 C CG  . ARG B 1 21  ? 47.10714  -6.32934  25.26369  1.000 60.17158 ? 21  ARG B CG  1 
ATOM   2059 C CD  . ARG B 1 21  ? 47.85613  -5.18178  24.62730  1.000 56.88062 ? 21  ARG B CD  1 
ATOM   2060 N NE  . ARG B 1 21  ? 48.64786  -5.64836  23.49691  1.000 57.97104 ? 21  ARG B NE  1 
ATOM   2061 C CZ  . ARG B 1 21  ? 49.39430  -4.86435  22.73180  1.000 63.65696 ? 21  ARG B CZ  1 
ATOM   2062 N NH1 . ARG B 1 21  ? 49.50599  -3.56880  22.97394  1.000 61.27021 ? 21  ARG B NH1 1 
ATOM   2063 N NH2 . ARG B 1 21  ? 50.04288  -5.39347  21.69590  1.000 55.63924 ? 21  ARG B NH2 1 
ATOM   2064 N N   . LEU B 1 22  ? 43.73789  -9.20272  25.10135  1.000 58.83702 ? 22  LEU B N   1 
ATOM   2065 C CA  . LEU B 1 22  ? 42.47396  -9.22410  25.81759  1.000 62.04766 ? 22  LEU B CA  1 
ATOM   2066 C C   . LEU B 1 22  ? 42.31768  -10.55461 26.54584  1.000 65.68407 ? 22  LEU B C   1 
ATOM   2067 O O   . LEU B 1 22  ? 42.83476  -11.58502 26.10604  1.000 56.55719 ? 22  LEU B O   1 
ATOM   2068 C CB  . LEU B 1 22  ? 41.31232  -9.00812  24.84201  1.000 56.33289 ? 22  LEU B CB  1 
ATOM   2069 C CG  . LEU B 1 22  ? 39.99163  -8.43410  25.35661  1.000 71.63500 ? 22  LEU B CG  1 
ATOM   2070 C CD1 . LEU B 1 22  ? 38.91029  -9.51688  25.42546  1.000 66.59055 ? 22  LEU B CD1 1 
ATOM   2071 C CD2 . LEU B 1 22  ? 40.18147  -7.74506  26.70973  1.000 66.10085 ? 22  LEU B CD2 1 
ATOM   2072 N N   . VAL B 1 23  ? 41.61118  -10.52251 27.67381  1.000 67.80961 ? 23  VAL B N   1 
ATOM   2073 C CA  . VAL B 1 23  ? 41.29213  -11.72573 28.43484  1.000 66.19193 ? 23  VAL B CA  1 
ATOM   2074 C C   . VAL B 1 23  ? 39.90282  -12.18263 28.01856  1.000 66.45063 ? 23  VAL B C   1 
ATOM   2075 O O   . VAL B 1 23  ? 38.92730  -11.43394 28.15447  1.000 76.15187 ? 23  VAL B O   1 
ATOM   2076 C CB  . VAL B 1 23  ? 41.35829  -11.47816 29.95000  1.000 65.85385 ? 23  VAL B CB  1 
ATOM   2077 C CG1 . VAL B 1 23  ? 41.47312  -12.80408 30.69656  1.000 58.12139 ? 23  VAL B CG1 1 
ATOM   2078 C CG2 . VAL B 1 23  ? 42.51756  -10.55134 30.29391  1.000 75.74785 ? 23  VAL B CG2 1 
ATOM   2079 N N   . ILE B 1 24  ? 39.80833  -13.40587 27.50865  1.000 59.81029 ? 24  ILE B N   1 
ATOM   2080 C CA  . ILE B 1 24  ? 38.55066  -13.96181 27.02944  1.000 65.62002 ? 24  ILE B CA  1 
ATOM   2081 C C   . ILE B 1 24  ? 38.19646  -15.17825 27.87169  1.000 59.22602 ? 24  ILE B C   1 
ATOM   2082 O O   . ILE B 1 24  ? 38.95568  -16.15195 27.90679  1.000 70.06968 ? 24  ILE B O   1 
ATOM   2083 C CB  . ILE B 1 24  ? 38.64557  -14.33480 25.54651  1.000 58.02276 ? 24  ILE B CB  1 
ATOM   2084 N N   . ASP B 1 25  ? 37.05070  -15.11758 28.55446  1.000 63.52687 ? 25  ASP B N   1 
ATOM   2085 C CA  . ASP B 1 25  ? 36.51538  -16.28060 29.25456  1.000 53.76469 ? 25  ASP B CA  1 
ATOM   2086 C C   . ASP B 1 25  ? 35.74364  -17.16044 28.28057  1.000 57.67201 ? 25  ASP B C   1 
ATOM   2087 O O   . ASP B 1 25  ? 36.00311  -17.12991 27.07399  1.000 64.83868 ? 25  ASP B O   1 
ATOM   2088 C CB  . ASP B 1 25  ? 35.60428  -15.85499 30.40153  1.000 47.40737 ? 25  ASP B CB  1 
ATOM   2089 C CG  . ASP B 1 25  ? 34.46079  -14.98472 29.93023  1.000 64.00506 ? 25  ASP B CG  1 
ATOM   2090 O OD1 . ASP B 1 25  ? 34.70220  -13.78030 29.69974  1.000 58.53305 ? 25  ASP B OD1 1 
ATOM   2091 O OD2 . ASP B 1 25  ? 33.33533  -15.51318 29.75524  1.000 48.37207 ? 25  ASP B OD2 1 
ATOM   2092 N N   . ALA B 1 26  ? 34.78373  -17.93320 28.78778  1.000 50.37998 ? 26  ALA B N   1 
ATOM   2093 C CA  . ALA B 1 26  ? 33.96237  -18.79909 27.95033  1.000 48.94488 ? 26  ALA B CA  1 
ATOM   2094 C C   . ALA B 1 26  ? 32.60776  -18.19893 27.60179  1.000 46.59902 ? 26  ALA B C   1 
ATOM   2095 O O   . ALA B 1 26  ? 32.09622  -18.45182 26.50468  1.000 46.46120 ? 26  ALA B O   1 
ATOM   2096 C CB  . ALA B 1 26  ? 33.74342  -20.15150 28.63441  1.000 51.96822 ? 26  ALA B CB  1 
ATOM   2097 N N   . GLU B 1 27  ? 32.00618  -17.42485 28.50843  1.000 46.35325 ? 27  GLU B N   1 
ATOM   2098 C CA  . GLU B 1 27  ? 30.77935  -16.71260 28.16713  1.000 50.14413 ? 27  GLU B CA  1 
ATOM   2099 C C   . GLU B 1 27  ? 31.03622  -15.68779 27.06513  1.000 42.22196 ? 27  GLU B C   1 
ATOM   2100 O O   . GLU B 1 27  ? 30.27352  -15.59388 26.09583  1.000 44.56830 ? 27  GLU B O   1 
ATOM   2101 C CB  . GLU B 1 27  ? 30.20276  -16.04193 29.41330  1.000 55.50279 ? 27  GLU B CB  1 
ATOM   2102 C CG  . GLU B 1 27  ? 28.85087  -15.38067 29.19798  1.000 52.08642 ? 27  GLU B CG  1 
ATOM   2103 C CD  . GLU B 1 27  ? 28.54640  -14.33789 30.26045  1.000 60.04029 ? 27  GLU B CD  1 
ATOM   2104 O OE1 . GLU B 1 27  ? 29.32924  -14.24647 31.23428  1.000 61.96476 ? 27  GLU B OE1 1 
ATOM   2105 O OE2 . GLU B 1 27  ? 27.53563  -13.60531 30.11887  1.000 57.84171 ? 27  GLU B OE2 1 
ATOM   2106 N N   . LEU B 1 28  ? 32.11289  -14.90888 27.19820  1.000 35.00822 ? 28  LEU B N   1 
ATOM   2107 C CA  . LEU B 1 28  ? 32.52866  -14.02834 26.11134  1.000 41.18950 ? 28  LEU B CA  1 
ATOM   2108 C C   . LEU B 1 28  ? 32.84537  -14.82679 24.85052  1.000 39.12674 ? 28  LEU B C   1 
ATOM   2109 O O   . LEU B 1 28  ? 32.39548  -14.47715 23.75105  1.000 28.37873 ? 28  LEU B O   1 
ATOM   2110 C CB  . LEU B 1 28  ? 33.73712  -13.20092 26.54446  1.000 40.74810 ? 28  LEU B CB  1 
ATOM   2111 C CG  . LEU B 1 28  ? 34.30139  -12.19374 25.54015  1.000 32.00781 ? 28  LEU B CG  1 
ATOM   2112 C CD1 . LEU B 1 28  ? 33.22706  -11.24944 25.05282  1.000 29.08759 ? 28  LEU B CD1 1 
ATOM   2113 C CD2 . LEU B 1 28  ? 35.44614  -11.41259 26.16616  1.000 43.81578 ? 28  LEU B CD2 1 
ATOM   2114 N N   . ARG B 1 29  ? 33.61539  -15.91139 24.99571  1.000 32.52690 ? 29  ARG B N   1 
ATOM   2115 C CA  . ARG B 1 29  ? 33.88149  -16.80961 23.87379  1.000 35.89960 ? 29  ARG B CA  1 
ATOM   2116 C C   . ARG B 1 29  ? 32.58703  -17.26493 23.20638  1.000 34.20375 ? 29  ARG B C   1 
ATOM   2117 O O   . ARG B 1 29  ? 32.46604  -17.24969 21.97709  1.000 27.37323 ? 29  ARG B O   1 
ATOM   2118 C CB  . ARG B 1 29  ? 34.68423  -18.02835 24.35193  1.000 56.54770 ? 29  ARG B CB  1 
ATOM   2119 C CG  . ARG B 1 29  ? 36.16387  -18.02861 23.96227  1.000 58.88795 ? 29  ARG B CG  1 
ATOM   2120 C CD  . ARG B 1 29  ? 36.94440  -19.15051 24.66974  1.000 63.01771 ? 29  ARG B CD  1 
ATOM   2121 N NE  . ARG B 1 29  ? 36.81549  -20.44704 24.01109  1.000 62.69567 ? 29  ARG B NE  1 
ATOM   2122 C CZ  . ARG B 1 29  ? 36.12766  -21.47844 24.48701  1.000 58.08317 ? 29  ARG B CZ  1 
ATOM   2123 N NH1 . ARG B 1 29  ? 35.47745  -21.40754 25.63753  1.000 50.19369 ? 29  ARG B NH1 1 
ATOM   2124 N NH2 . ARG B 1 29  ? 36.09635  -22.61293 23.79168  1.000 52.91340 ? 29  ARG B NH2 1 
ATOM   2125 N N   . GLN B 1 30  ? 31.59963  -17.67456 24.00321  1.000 32.76909 ? 30  GLN B N   1 
ATOM   2126 C CA  . GLN B 1 30  ? 30.35976  -18.15232 23.40240  1.000 29.43454 ? 30  GLN B CA  1 
ATOM   2127 C C   . GLN B 1 30  ? 29.62632  -17.03406 22.66564  1.000 35.30098 ? 30  GLN B C   1 
ATOM   2128 O O   . GLN B 1 30  ? 29.13775  -17.23898 21.54751  1.000 27.89738 ? 30  GLN B O   1 
ATOM   2129 C CB  . GLN B 1 30  ? 29.46425  -18.77833 24.46620  1.000 34.63433 ? 30  GLN B CB  1 
ATOM   2130 C CG  . GLN B 1 30  ? 28.46684  -19.76029 23.89041  1.000 47.08976 ? 30  GLN B CG  1 
ATOM   2131 C CD  . GLN B 1 30  ? 29.02345  -20.51099 22.68247  1.000 51.41118 ? 30  GLN B CD  1 
ATOM   2132 O OE1 . GLN B 1 30  ? 28.53755  -20.34427 21.56255  1.000 55.94787 ? 30  GLN B OE1 1 
ATOM   2133 N NE2 . GLN B 1 30  ? 30.04727  -21.33860 22.90483  1.000 48.58705 ? 30  GLN B NE2 1 
ATOM   2134 N N   . HIS B 1 31  ? 29.56038  -15.83559 23.25449  1.000 26.76102 ? 31  HIS B N   1 
ATOM   2135 C CA  . HIS B 1 31  ? 28.76779  -14.78169 22.62534  1.000 24.86913 ? 31  HIS B CA  1 
ATOM   2136 C C   . HIS B 1 31  ? 29.46029  -14.19809 21.40512  1.000 16.48413 ? 31  HIS B C   1 
ATOM   2137 O O   . HIS B 1 31  ? 28.77985  -13.71976 20.49220  1.000 21.54475 ? 31  HIS B O   1 
ATOM   2138 C CB  . HIS B 1 31  ? 28.44198  -13.67673 23.62712  1.000 25.23624 ? 31  HIS B CB  1 
ATOM   2139 C CG  . HIS B 1 31  ? 27.46359  -14.09479 24.67319  1.000 27.44060 ? 31  HIS B CG  1 
ATOM   2140 N ND1 . HIS B 1 31  ? 26.19245  -14.53633 24.36856  1.000 28.20278 ? 31  HIS B ND1 1 
ATOM   2141 C CD2 . HIS B 1 31  ? 27.57196  -14.14888 26.02011  1.000 24.89395 ? 31  HIS B CD2 1 
ATOM   2142 C CE1 . HIS B 1 31  ? 25.55704  -14.83331 25.48787  1.000 31.86927 ? 31  HIS B CE1 1 
ATOM   2143 N NE2 . HIS B 1 31  ? 26.37139  -14.60417 26.50356  1.000 31.36661 ? 31  HIS B NE2 1 
ATOM   2144 N N   . VAL B 1 32  ? 30.79683  -14.22640 21.36317  1.000 19.00423 ? 32  VAL B N   1 
ATOM   2145 C CA  . VAL B 1 32  ? 31.50919  -13.78579 20.16453  1.000 21.19636 ? 32  VAL B CA  1 
ATOM   2146 C C   . VAL B 1 32  ? 31.15130  -14.67013 18.97630  1.000 25.24150 ? 32  VAL B C   1 
ATOM   2147 O O   . VAL B 1 32  ? 30.94519  -14.18518 17.85606  1.000 16.71233 ? 32  VAL B O   1 
ATOM   2148 C CB  . VAL B 1 32  ? 33.03075  -13.77222 20.40851  1.000 25.42872 ? 32  VAL B CB  1 
ATOM   2149 C CG1 . VAL B 1 32  ? 33.76265  -13.47011 19.13245  1.000 24.09500 ? 32  VAL B CG1 1 
ATOM   2150 C CG2 . VAL B 1 32  ? 33.40689  -12.73396 21.43971  1.000 33.92321 ? 32  VAL B CG2 1 
ATOM   2151 N N   . LYS B 1 33  ? 31.07895  -15.98062 19.19472  1.000 23.19850 ? 33  LYS B N   1 
ATOM   2152 C CA  . LYS B 1 33  ? 30.74190  -16.86978 18.08895  1.000 24.76443 ? 33  LYS B CA  1 
ATOM   2153 C C   . LYS B 1 33  ? 29.30468  -16.65455 17.63270  1.000 17.60098 ? 33  LYS B C   1 
ATOM   2154 O O   . LYS B 1 33  ? 29.03138  -16.61828 16.43037  1.000 21.16219 ? 33  LYS B O   1 
ATOM   2155 C CB  . LYS B 1 33  ? 30.97980  -18.32791 18.49453  1.000 24.81863 ? 33  LYS B CB  1 
ATOM   2156 C CG  . LYS B 1 33  ? 32.36951  -18.85646 18.11292  1.000 36.71044 ? 33  LYS B CG  1 
ATOM   2157 C CD  . LYS B 1 33  ? 33.49530  -18.04851 18.76109  1.000 39.32122 ? 33  LYS B CD  1 
ATOM   2158 C CE  . LYS B 1 33  ? 34.10819  -18.80569 19.93270  1.000 41.31539 ? 33  LYS B CE  1 
ATOM   2159 N NZ  . LYS B 1 33  ? 34.86440  -17.91680 20.86116  1.000 40.26797 ? 33  LYS B NZ  1 
ATOM   2160 N N   . GLU B 1 34  ? 28.37814  -16.48476 18.57925  1.000 24.03444 ? 34  GLU B N   1 
ATOM   2161 C CA  . GLU B 1 34  ? 26.99528  -16.16991 18.22461  1.000 23.60576 ? 34  GLU B CA  1 
ATOM   2162 C C   . GLU B 1 34  ? 26.90604  -14.87200 17.43015  1.000 19.25857 ? 34  GLU B C   1 
ATOM   2163 O O   . GLU B 1 34  ? 26.16052  -14.78921 16.44542  1.000 21.01199 ? 34  GLU B O   1 
ATOM   2164 C CB  . GLU B 1 34  ? 26.13704  -16.06890 19.48616  1.000 28.78523 ? 34  GLU B CB  1 
ATOM   2165 C CG  . GLU B 1 34  ? 26.06840  -17.34373 20.31301  1.000 39.69176 ? 34  GLU B CG  1 
ATOM   2166 C CD  . GLU B 1 34  ? 25.45034  -17.11854 21.68647  1.000 40.40534 ? 34  GLU B CD  1 
ATOM   2167 O OE1 . GLU B 1 34  ? 25.74854  -16.08131 22.32666  1.000 38.80511 ? 34  GLU B OE1 1 
ATOM   2168 O OE2 . GLU B 1 34  ? 24.66519  -17.97952 22.12697  1.000 47.60143 ? 34  GLU B OE2 1 
ATOM   2169 N N   . LEU B 1 35  ? 27.65176  -13.84011 17.85399  1.000 19.24543 ? 35  LEU B N   1 
ATOM   2170 C CA  . LEU B 1 35  ? 27.63434  -12.55515 17.15493  1.000 13.59660 ? 35  LEU B CA  1 
ATOM   2171 C C   . LEU B 1 35  ? 28.27235  -12.65919 15.77369  1.000 20.46381 ? 35  LEU B C   1 
ATOM   2172 O O   . LEU B 1 35  ? 27.70978  -12.17697 14.78209  1.000 17.86135 ? 35  LEU B O   1 
ATOM   2173 C CB  . LEU B 1 35  ? 28.35324  -11.48811 17.99106  1.000 12.36605 ? 35  LEU B CB  1 
ATOM   2174 C CG  . LEU B 1 35  ? 28.37856  -10.07884 17.37823  1.000 16.24824 ? 35  LEU B CG  1 
ATOM   2175 C CD1 . LEU B 1 35  ? 26.94963  -9.53826  17.18522  1.000 12.22277 ? 35  LEU B CD1 1 
ATOM   2176 C CD2 . LEU B 1 35  ? 29.20995  -9.11374  18.23035  1.000 15.11556 ? 35  LEU B CD2 1 
ATOM   2177 N N   . ALA B 1 36  ? 29.45042  -13.27422 15.68107  1.000 18.14889 ? 36  ALA B N   1 
ATOM   2178 C CA  . ALA B 1 36  ? 30.13326  -13.31334 14.39208  1.000 17.94201 ? 36  ALA B CA  1 
ATOM   2179 C C   . ALA B 1 36  ? 29.34158  -14.10254 13.35597  1.000 17.00088 ? 36  ALA B C   1 
ATOM   2180 O O   . ALA B 1 36  ? 29.38478  -13.77325 12.16607  1.000 18.82480 ? 36  ALA B O   1 
ATOM   2181 C CB  . ALA B 1 36  ? 31.53382  -13.90166 14.55146  1.000 14.28741 ? 36  ALA B CB  1 
ATOM   2182 N N   . ALA B 1 37  ? 28.62052  -15.13783 13.78404  1.000 17.13556 ? 37  ALA B N   1 
ATOM   2183 C CA  . ALA B 1 37  ? 27.79847  -15.91327 12.85929  1.000 23.80507 ? 37  ALA B CA  1 
ATOM   2184 C C   . ALA B 1 37  ? 26.71322  -15.06652 12.20369  1.000 26.30166 ? 37  ALA B C   1 
ATOM   2185 O O   . ALA B 1 37  ? 26.24848  -15.41485 11.10793  1.000 23.64308 ? 37  ALA B O   1 
ATOM   2186 C CB  . ALA B 1 37  ? 27.16738  -17.10012 13.59252  1.000 18.22212 ? 37  ALA B CB  1 
ATOM   2187 N N   . GLU B 1 38  ? 26.31095  -13.95813 12.84473  1.000 25.89836 ? 38  GLU B N   1 
ATOM   2188 C CA  . GLU B 1 38  ? 25.31496  -13.05561 12.26152  1.000 29.11394 ? 38  GLU B CA  1 
ATOM   2189 C C   . GLU B 1 38  ? 25.74208  -12.52920 10.91003  1.000 22.07892 ? 38  GLU B C   1 
ATOM   2190 O O   . GLU B 1 38  ? 24.89126  -12.23684 10.05987  1.000 27.68910 ? 38  GLU B O   1 
ATOM   2191 C CB  . GLU B 1 38  ? 25.06153  -11.86088 13.17686  1.000 23.12014 ? 38  GLU B CB  1 
ATOM   2192 C CG  . GLU B 1 38  ? 24.51294  -12.22865 14.50311  1.000 23.75197 ? 38  GLU B CG  1 
ATOM   2193 C CD  . GLU B 1 38  ? 23.08473  -12.70340 14.43429  1.000 28.13200 ? 38  GLU B CD  1 
ATOM   2194 O OE1 . GLU B 1 38  ? 22.39953  -12.47141 13.40723  1.000 31.59113 ? 38  GLU B OE1 1 
ATOM   2195 O OE2 . GLU B 1 38  ? 22.64872  -13.30334 15.43124  1.000 30.64434 ? 38  GLU B OE2 1 
ATOM   2196 N N   . TRP B 1 39  ? 27.04427  -12.36456 10.69880  1.000 19.50325 ? 39  TRP B N   1 
ATOM   2197 C CA  . TRP B 1 39  ? 27.51627  -11.86992 9.41318   1.000 23.63532 ? 39  TRP B CA  1 
ATOM   2198 C C   . TRP B 1 39  ? 27.21261  -12.81482 8.24957   1.000 27.76601 ? 39  TRP B C   1 
ATOM   2199 O O   . TRP B 1 39  ? 27.39204  -12.41507 7.09129   1.000 23.36283 ? 39  TRP B O   1 
ATOM   2200 C CB  . TRP B 1 39  ? 29.01658  -11.60494 9.48850   1.000 19.13461 ? 39  TRP B CB  1 
ATOM   2201 C CG  . TRP B 1 39  ? 29.33907  -10.23480 10.00033  1.000 19.08348 ? 39  TRP B CG  1 
ATOM   2202 C CD1 . TRP B 1 39  ? 29.84210  -9.19513  9.27979   1.000 13.91778 ? 39  TRP B CD1 1 
ATOM   2203 C CD2 . TRP B 1 39  ? 29.15697  -9.74891  11.33452  1.000 19.51946 ? 39  TRP B CD2 1 
ATOM   2204 N NE1 . TRP B 1 39  ? 29.99814  -8.10321  10.07692  1.000 15.43971 ? 39  TRP B NE1 1 
ATOM   2205 C CE2 . TRP B 1 39  ? 29.58273  -8.41294  11.34784  1.000 18.38400 ? 39  TRP B CE2 1 
ATOM   2206 C CE3 . TRP B 1 39  ? 28.68995  -10.31890 12.52110  1.000 20.15980 ? 39  TRP B CE3 1 
ATOM   2207 C CZ2 . TRP B 1 39  ? 29.56448  -7.63136  12.50519  1.000 13.89758 ? 39  TRP B CZ2 1 
ATOM   2208 C CZ3 . TRP B 1 39  ? 28.65819  -9.53424  13.66995  1.000 17.97277 ? 39  TRP B CZ3 1 
ATOM   2209 C CH2 . TRP B 1 39  ? 29.09268  -8.20825  13.65250  1.000 11.87300 ? 39  TRP B CH2 1 
ATOM   2210 N N   . GLU B 1 40  ? 26.77544  -14.04599 8.52070   1.000 27.25664 ? 40  GLU B N   1 
ATOM   2211 C CA  . GLU B 1 40  ? 26.41713  -14.99021 7.46610   1.000 37.48445 ? 40  GLU B CA  1 
ATOM   2212 C C   . GLU B 1 40  ? 24.99711  -14.79202 6.95766   1.000 40.94500 ? 40  GLU B C   1 
ATOM   2213 O O   . GLU B 1 40  ? 24.57285  -15.51813 6.05187   1.000 41.34543 ? 40  GLU B O   1 
ATOM   2214 C CB  . GLU B 1 40  ? 26.56851  -16.43587 7.95877   1.000 36.35564 ? 40  GLU B CB  1 
ATOM   2215 C CG  . GLU B 1 40  ? 27.97585  -16.83110 8.38226   1.000 31.39553 ? 40  GLU B CG  1 
ATOM   2216 C CD  . GLU B 1 40  ? 28.92354  -16.98465 7.20676   1.000 43.82114 ? 40  GLU B CD  1 
ATOM   2217 O OE1 . GLU B 1 40  ? 28.44325  -17.09973 6.05653   1.000 38.26116 ? 40  GLU B OE1 1 
ATOM   2218 O OE2 . GLU B 1 40  ? 30.15532  -16.98602 7.43389   1.000 36.18529 ? 40  GLU B OE2 1 
ATOM   2219 N N   . ASN B 1 41  ? 24.24660  -13.84422 7.52046   1.000 43.26012 ? 41  ASN B N   1 
ATOM   2220 C CA  . ASN B 1 41  ? 22.85096  -13.64486 7.14669   1.000 33.41562 ? 41  ASN B CA  1 
ATOM   2221 C C   . ASN B 1 41  ? 22.55713  -12.18280 6.88702   1.000 30.75803 ? 41  ASN B C   1 
ATOM   2222 O O   . ASN B 1 41  ? 21.46463  -11.70637 7.20622   1.000 34.52233 ? 41  ASN B O   1 
ATOM   2223 C CB  . ASN B 1 41  ? 21.91023  -14.18277 8.22154   1.000 37.82238 ? 41  ASN B CB  1 
ATOM   2224 C CG  . ASN B 1 41  ? 22.01790  -15.68605 8.38564   1.000 54.32952 ? 41  ASN B CG  1 
ATOM   2225 O OD1 . ASN B 1 41  ? 22.37340  -16.40440 7.44454   1.000 54.60576 ? 41  ASN B OD1 1 
ATOM   2226 N ND2 . ASN B 1 41  ? 21.71480  -16.17302 9.58697   1.000 55.85474 ? 41  ASN B ND2 1 
ATOM   2227 N N   . LEU B 1 42  ? 23.52663  -11.45773 6.33058   1.000 34.54765 ? 42  LEU B N   1 
ATOM   2228 C CA  . LEU B 1 42  ? 23.33733  -10.05903 5.97855   1.000 28.24507 ? 42  LEU B CA  1 
ATOM   2229 C C   . LEU B 1 42  ? 22.82797  -9.95331  4.54885   1.000 37.40112 ? 42  LEU B C   1 
ATOM   2230 O O   . LEU B 1 42  ? 23.04560  -10.84701 3.72590   1.000 36.79023 ? 42  LEU B O   1 
ATOM   2231 C CB  . LEU B 1 42  ? 24.63959  -9.27455  6.12324   1.000 26.19994 ? 42  LEU B CB  1 
ATOM   2232 C CG  . LEU B 1 42  ? 25.35883  -9.27030  7.47315   1.000 30.05428 ? 42  LEU B CG  1 
ATOM   2233 C CD1 . LEU B 1 42  ? 26.67492  -8.53896  7.31988   1.000 23.14766 ? 42  LEU B CD1 1 
ATOM   2234 C CD2 . LEU B 1 42  ? 24.50292  -8.60528  8.53715   1.000 25.13687 ? 42  LEU B CD2 1 
ATOM   2235 N N   . GLU B 1 43  ? 22.14798  -8.84794  4.25725   1.000 37.37844 ? 43  GLU B N   1 
ATOM   2236 C CA  . GLU B 1 43  ? 21.57253  -8.63310  2.93889   1.000 44.48509 ? 43  GLU B CA  1 
ATOM   2237 C C   . GLU B 1 43  ? 22.53340  -7.84174  2.06196   1.000 41.14793 ? 43  GLU B C   1 
ATOM   2238 O O   . GLU B 1 43  ? 23.25438  -6.96296  2.54422   1.000 43.34595 ? 43  GLU B O   1 
ATOM   2239 C CB  . GLU B 1 43  ? 20.22650  -7.91436  3.05040   1.000 45.38067 ? 43  GLU B CB  1 
ATOM   2240 C CG  . GLU B 1 43  ? 19.34236  -8.40645  4.19364   1.000 48.26366 ? 43  GLU B CG  1 
ATOM   2241 C CD  . GLU B 1 43  ? 18.89656  -9.86608  4.05836   1.000 71.66016 ? 43  GLU B CD  1 
ATOM   2242 O OE1 . GLU B 1 43  ? 19.36019  -10.58242 3.13959   1.000 69.65991 ? 43  GLU B OE1 1 
ATOM   2243 O OE2 . GLU B 1 43  ? 18.06442  -10.30212 4.88708   1.000 78.92866 ? 43  GLU B OE2 1 
ATOM   2244 N N   . THR B 1 44  ? 22.53208  -8.15935  0.76771   1.000 50.10559 ? 44  THR B N   1 
ATOM   2245 C CA  . THR B 1 44  ? 23.53516  -7.65073  -0.15396  1.000 55.81145 ? 44  THR B CA  1 
ATOM   2246 C C   . THR B 1 44  ? 23.21803  -6.21888  -0.58792  1.000 56.54295 ? 44  THR B C   1 
ATOM   2247 O O   . THR B 1 44  ? 22.15461  -5.66564  -0.29329  1.000 54.90379 ? 44  THR B O   1 
ATOM   2248 C CB  . THR B 1 44  ? 23.64554  -8.55719  -1.37817  1.000 56.75563 ? 44  THR B CB  1 
ATOM   2249 O OG1 . THR B 1 44  ? 22.62469  -8.20909  -2.32290  1.000 85.57243 ? 44  THR B OG1 1 
ATOM   2250 C CG2 . THR B 1 44  ? 23.46783  -10.01009 -0.97063  1.000 54.41198 ? 44  THR B CG2 1 
ATOM   2251 N N   . ASP B 1 45  ? 24.17453  -5.63541  -1.31938  1.000 68.36393 ? 45  ASP B N   1 
ATOM   2252 C CA  . ASP B 1 45  ? 24.21195  -4.23115  -1.72405  1.000 60.99172 ? 45  ASP B CA  1 
ATOM   2253 C C   . ASP B 1 45  ? 24.35767  -3.32633  -0.50467  1.000 58.86894 ? 45  ASP B C   1 
ATOM   2254 O O   . ASP B 1 45  ? 23.57624  -3.41658  0.44850   1.000 55.20770 ? 45  ASP B O   1 
ATOM   2255 C CB  . ASP B 1 45  ? 22.97647  -3.85270  -2.54616  1.000 71.37595 ? 45  ASP B CB  1 
ATOM   2256 C CG  . ASP B 1 45  ? 23.23346  -2.67410  -3.47427  1.000 80.45939 ? 45  ASP B CG  1 
ATOM   2257 O OD1 . ASP B 1 45  ? 24.01469  -2.84035  -4.43629  1.000 75.05528 ? 45  ASP B OD1 1 
ATOM   2258 O OD2 . ASP B 1 45  ? 22.65851  -1.58539  -3.24279  1.000 82.52687 ? 45  ASP B OD2 1 
ATOM   2259 N N   . ARG B 1 46  ? 25.36790  -2.46024  -0.52105  1.000 66.48764 ? 46  ARG B N   1 
ATOM   2260 C CA  . ARG B 1 46  ? 25.64466  -1.58039  0.61435   1.000 65.61184 ? 46  ARG B CA  1 
ATOM   2261 C C   . ARG B 1 46  ? 24.69323  -0.38469  0.64298   1.000 65.84725 ? 46  ARG B C   1 
ATOM   2262 O O   . ARG B 1 46  ? 23.70658  -0.37949  1.38341   1.000 49.50595 ? 46  ARG B O   1 
ATOM   2263 C CB  . ARG B 1 46  ? 27.10326  -1.09957  0.58611   1.000 47.28817 ? 46  ARG B CB  1 
ATOM   2264 C CG  . ARG B 1 46  ? 27.53697  -0.51858  -0.75426  1.000 70.42244 ? 46  ARG B CG  1 
ATOM   2265 C CD  . ARG B 1 46  ? 29.05290  -0.53463  -0.92679  1.000 67.96526 ? 46  ARG B CD  1 
ATOM   2266 N NE  . ARG B 1 46  ? 29.42786  -0.77048  -2.31778  1.000 64.65678 ? 46  ARG B NE  1 
ATOM   2267 C CZ  . ARG B 1 46  ? 30.67612  -0.83103  -2.76632  1.000 69.89120 ? 46  ARG B CZ  1 
ATOM   2268 N NH1 . ARG B 1 46  ? 31.71394  -0.64207  -1.96394  1.000 65.16864 ? 46  ARG B NH1 1 
ATOM   2269 N NH2 . ARG B 1 46  ? 30.88995  -1.09182  -4.05314  1.000 69.35476 ? 46  ARG B NH2 1 
ATOM   2270 N N   . GLY B 1 51  ? 30.60896  -8.11664  -9.78651  1.000 50.00624 ? 51  GLY B N   1 
ATOM   2271 C CA  . GLY B 1 51  ? 31.42164  -6.99463  -10.22779 1.000 61.62793 ? 51  GLY B CA  1 
ATOM   2272 C C   . GLY B 1 51  ? 32.91352  -7.22315  -10.04405 1.000 63.89636 ? 51  GLY B C   1 
ATOM   2273 O O   . GLY B 1 51  ? 33.68030  -7.13563  -11.00594 1.000 72.86783 ? 51  GLY B O   1 
ATOM   2274 N N   . SER B 1 52  ? 33.29461  -7.50612  -8.79426  1.000 57.29440 ? 52  SER B N   1 
ATOM   2275 C CA  . SER B 1 52  ? 34.64286  -7.83814  -8.33141  1.000 59.89202 ? 52  SER B CA  1 
ATOM   2276 C C   . SER B 1 52  ? 34.65429  -7.64860  -6.82024  1.000 59.46613 ? 52  SER B C   1 
ATOM   2277 O O   . SER B 1 52  ? 35.44506  -8.26936  -6.09938  1.000 53.83541 ? 52  SER B O   1 
ATOM   2278 C CB  . SER B 1 52  ? 35.73154  -6.97407  -8.97902  1.000 50.07908 ? 52  SER B CB  1 
ATOM   2279 O OG  . SER B 1 52  ? 37.02643  -7.44437  -8.62993  1.000 49.65080 ? 52  SER B OG  1 
ATOM   2280 N N   . ARG B 1 53  ? 33.75346  -6.79460  -6.34165  1.000 56.57136 ? 53  ARG B N   1 
ATOM   2281 C CA  . ARG B 1 53  ? 33.61477  -6.47131  -4.93023  1.000 44.92508 ? 53  ARG B CA  1 
ATOM   2282 C C   . ARG B 1 53  ? 32.13456  -6.44761  -4.58193  1.000 49.62928 ? 53  ARG B C   1 
ATOM   2283 O O   . ARG B 1 53  ? 31.33076  -5.88536  -5.33205  1.000 51.72236 ? 53  ARG B O   1 
ATOM   2284 C CB  . ARG B 1 53  ? 34.26277  -5.11682  -4.60856  1.000 48.96362 ? 53  ARG B CB  1 
ATOM   2285 C CG  . ARG B 1 53  ? 35.76197  -5.18251  -4.33122  1.000 56.72446 ? 53  ARG B CG  1 
ATOM   2286 C CD  . ARG B 1 53  ? 36.59188  -5.26233  -5.60034  1.000 56.39857 ? 53  ARG B CD  1 
ATOM   2287 N NE  . ARG B 1 53  ? 37.87885  -5.90409  -5.35820  1.000 57.31878 ? 53  ARG B NE  1 
ATOM   2288 C CZ  . ARG B 1 53  ? 39.01946  -5.25467  -5.17104  1.000 65.19704 ? 53  ARG B CZ  1 
ATOM   2289 N NH1 . ARG B 1 53  ? 39.07828  -3.92970  -5.21881  1.000 58.01167 ? 53  ARG B NH1 1 
ATOM   2290 N NH2 . ARG B 1 53  ? 40.12972  -5.95135  -4.93513  1.000 51.81506 ? 53  ARG B NH2 1 
ATOM   2291 N N   . PHE B 1 54  ? 31.77521  -7.07444  -3.46163  1.000 37.95065 ? 54  PHE B N   1 
ATOM   2292 C CA  . PHE B 1 54  ? 30.41527  -7.05376  -2.94246  1.000 27.35977 ? 54  PHE B CA  1 
ATOM   2293 C C   . PHE B 1 54  ? 30.43999  -6.65772  -1.46961  1.000 41.96153 ? 54  PHE B C   1 
ATOM   2294 O O   . PHE B 1 54  ? 31.43627  -6.85778  -0.76611  1.000 33.84463 ? 54  PHE B O   1 
ATOM   2295 C CB  . PHE B 1 54  ? 29.71379  -8.41266  -3.07831  1.000 36.42739 ? 54  PHE B CB  1 
ATOM   2296 C CG  . PHE B 1 54  ? 29.68329  -8.95314  -4.47902  1.000 51.79399 ? 54  PHE B CG  1 
ATOM   2297 C CD1 . PHE B 1 54  ? 28.67424  -8.59115  -5.35394  1.000 52.87036 ? 54  PHE B CD1 1 
ATOM   2298 C CD2 . PHE B 1 54  ? 30.65240  -9.83900  -4.91747  1.000 54.72710 ? 54  PHE B CD2 1 
ATOM   2299 C CE1 . PHE B 1 54  ? 28.63696  -9.09317  -6.64109  1.000 48.53274 ? 54  PHE B CE1 1 
ATOM   2300 C CE2 . PHE B 1 54  ? 30.61155  -10.34567 -6.20927  1.000 55.00480 ? 54  PHE B CE2 1 
ATOM   2301 C CZ  . PHE B 1 54  ? 29.60716  -9.96995  -7.06523  1.000 48.30101 ? 54  PHE B CZ  1 
ATOM   2302 N N   . ARG B 1 55  ? 29.31366  -6.11630  -1.00445  1.000 35.19790 ? 55  ARG B N   1 
ATOM   2303 C CA  . ARG B 1 55  ? 29.18218  -5.62465  0.36429   1.000 40.84345 ? 55  ARG B CA  1 
ATOM   2304 C C   . ARG B 1 55  ? 27.78816  -5.95290  0.87257   1.000 36.86928 ? 55  ARG B C   1 
ATOM   2305 O O   . ARG B 1 55  ? 26.79664  -5.55598  0.25529   1.000 34.26833 ? 55  ARG B O   1 
ATOM   2306 C CB  . ARG B 1 55  ? 29.44171  -4.11428  0.43024   1.000 40.89661 ? 55  ARG B CB  1 
ATOM   2307 C CG  . ARG B 1 55  ? 29.48285  -3.53564  1.84163   1.000 49.91423 ? 55  ARG B CG  1 
ATOM   2308 C CD  . ARG B 1 55  ? 30.48257  -2.37898  1.92544   1.000 62.47800 ? 55  ARG B CD  1 
ATOM   2309 N NE  . ARG B 1 55  ? 29.88556  -1.12487  2.37297   1.000 56.63489 ? 55  ARG B NE  1 
ATOM   2310 C CZ  . ARG B 1 55  ? 30.52759  0.03649   2.41369   1.000 65.41646 ? 55  ARG B CZ  1 
ATOM   2311 N NH1 . ARG B 1 55  ? 31.79598  0.14057   2.04495   1.000 59.03609 ? 55  ARG B NH1 1 
ATOM   2312 N NH2 . ARG B 1 55  ? 29.88102  1.12246   2.83143   1.000 60.62909 ? 55  ARG B NH2 1 
ATOM   2313 N N   . GLU B 1 56  ? 27.71551  -6.69710  1.97549   1.000 25.74301 ? 56  GLU B N   1 
ATOM   2314 C CA  . GLU B 1 56  ? 26.47627  -6.94653  2.69763   1.000 24.54583 ? 56  GLU B CA  1 
ATOM   2315 C C   . GLU B 1 56  ? 26.54225  -6.22148  4.03664   1.000 26.04261 ? 56  GLU B C   1 
ATOM   2316 O O   . GLU B 1 56  ? 27.60677  -6.14808  4.65568   1.000 26.44803 ? 56  GLU B O   1 
ATOM   2317 C CB  . GLU B 1 56  ? 26.23899  -8.44322  2.92774   1.000 22.11645 ? 56  GLU B CB  1 
ATOM   2318 C CG  . GLU B 1 56  ? 26.45581  -9.30412  1.70462   1.000 32.76156 ? 56  GLU B CG  1 
ATOM   2319 C CD  . GLU B 1 56  ? 26.35977  -10.79413 2.00455   1.000 46.57614 ? 56  GLU B CD  1 
ATOM   2320 O OE1 . GLU B 1 56  ? 26.10848  -11.17058 3.17100   1.000 48.49389 ? 56  GLU B OE1 1 
ATOM   2321 O OE2 . GLU B 1 56  ? 26.53526  -11.59485 1.06763   1.000 46.43814 ? 56  GLU B OE2 1 
ATOM   2322 N N   . ARG B 1 57  ? 25.41624  -5.67641  4.48686   1.000 26.22340 ? 57  ARG B N   1 
ATOM   2323 C CA  . ARG B 1 57  ? 25.50491  -4.82123  5.66071   1.000 32.03517 ? 57  ARG B CA  1 
ATOM   2324 C C   . ARG B 1 57  ? 24.19249  -4.80402  6.42316   1.000 28.32167 ? 57  ARG B C   1 
ATOM   2325 O O   . ARG B 1 57  ? 23.15312  -5.27760  5.94997   1.000 27.75026 ? 57  ARG B O   1 
ATOM   2326 C CB  . ARG B 1 57  ? 25.90740  -3.39167  5.27630   1.000 33.18188 ? 57  ARG B CB  1 
ATOM   2327 C CG  . ARG B 1 57  ? 24.77868  -2.61455  4.64245   1.000 34.41392 ? 57  ARG B CG  1 
ATOM   2328 C CD  . ARG B 1 57  ? 25.25876  -1.32091  4.04901   1.000 46.66513 ? 57  ARG B CD  1 
ATOM   2329 N NE  . ARG B 1 57  ? 25.86997  -0.43435  5.03057   1.000 58.78396 ? 57  ARG B NE  1 
ATOM   2330 C CZ  . ARG B 1 57  ? 26.14264  0.84341   4.80474   1.000 59.90949 ? 57  ARG B CZ  1 
ATOM   2331 N NH1 . ARG B 1 57  ? 25.85741  1.41523   3.64522   1.000 66.04385 ? 57  ARG B NH1 1 
ATOM   2332 N NH2 . ARG B 1 57  ? 26.70571  1.56784   5.76761   1.000 55.75658 ? 57  ARG B NH2 1 
ATOM   2333 N N   . ALA B 1 58  ? 24.27379  -4.25190  7.63030   1.000 21.93713 ? 58  ALA B N   1 
ATOM   2334 C CA  . ALA B 1 58  ? 23.12231  -4.01931  8.48448   1.000 15.75625 ? 58  ALA B CA  1 
ATOM   2335 C C   . ALA B 1 58  ? 23.49558  -2.89063  9.43242   1.000 23.90038 ? 58  ALA B C   1 
ATOM   2336 O O   . ALA B 1 58  ? 24.68024  -2.58580  9.63081   1.000 21.57691 ? 58  ALA B O   1 
ATOM   2337 C CB  . ALA B 1 58  ? 22.70682  -5.27807  9.24316   1.000 19.29762 ? 58  ALA B CB  1 
ATOM   2338 N N   . TYR B 1 59  ? 22.48293  -2.25512  10.01235  1.000 18.69822 ? 59  TYR B N   1 
ATOM   2339 C CA  . TYR B 1 59  ? 22.77737  -0.98534  10.65047  1.000 21.05145 ? 59  TYR B CA  1 
ATOM   2340 C C   . TYR B 1 59  ? 21.65901  -0.58717  11.59709  1.000 26.23814 ? 59  TYR B C   1 
ATOM   2341 O O   . TYR B 1 59  ? 20.48523  -0.86072  11.33539  1.000 20.49575 ? 59  TYR B O   1 
ATOM   2342 C CB  . TYR B 1 59  ? 22.99179  0.07096   9.56704   1.000 27.61868 ? 59  TYR B CB  1 
ATOM   2343 C CG  . TYR B 1 59  ? 22.81374  1.50102   9.97367   1.000 27.14471 ? 59  TYR B CG  1 
ATOM   2344 C CD1 . TYR B 1 59  ? 23.80714  2.16430   10.65949  1.000 28.83403 ? 59  TYR B CD1 1 
ATOM   2345 C CD2 . TYR B 1 59  ? 21.67425  2.20898   9.62150   1.000 33.73598 ? 59  TYR B CD2 1 
ATOM   2346 C CE1 . TYR B 1 59  ? 23.67120  3.48436   11.00287  1.000 36.53352 ? 59  TYR B CE1 1 
ATOM   2347 C CE2 . TYR B 1 59  ? 21.52474  3.53170   9.97023   1.000 33.27490 ? 59  TYR B CE2 1 
ATOM   2348 C CZ  . TYR B 1 59  ? 22.53132  4.16420   10.65657  1.000 37.06635 ? 59  TYR B CZ  1 
ATOM   2349 O OH  . TYR B 1 59  ? 22.42536  5.48631   11.00844  1.000 44.43333 ? 59  TYR B OH  1 
ATOM   2350 N N   . ASP B 1 60  ? 22.04197  0.06691   12.69847  1.000 19.46122 ? 60  ASP B N   1 
ATOM   2351 C CA  . ASP B 1 60  ? 21.08533  0.70816   13.58989  1.000 17.63204 ? 60  ASP B CA  1 
ATOM   2352 C C   . ASP B 1 60  ? 21.83794  1.71339   14.44422  1.000 18.27531 ? 60  ASP B C   1 
ATOM   2353 O O   . ASP B 1 60  ? 23.06938  1.71358   14.49338  1.000 16.43793 ? 60  ASP B O   1 
ATOM   2354 C CB  . ASP B 1 60  ? 20.32850  -0.30355  14.46432  1.000 16.61353 ? 60  ASP B CB  1 
ATOM   2355 C CG  . ASP B 1 60  ? 19.09428  -0.87890  13.76548  1.000 20.38886 ? 60  ASP B CG  1 
ATOM   2356 O OD1 . ASP B 1 60  ? 18.32295  -0.09509  13.16853  1.000 18.71093 ? 60  ASP B OD1 1 
ATOM   2357 O OD2 . ASP B 1 60  ? 18.90748  -2.11693  13.78504  1.000 21.11294 ? 60  ASP B OD2 1 
ATOM   2358 N N   . ARG B 1 61  ? 21.07523  2.58815   15.09515  1.000 18.19164 ? 61  ARG B N   1 
ATOM   2359 C CA  . ARG B 1 61  ? 21.61465  3.66036   15.91230  1.000 17.63506 ? 61  ARG B CA  1 
ATOM   2360 C C   . ARG B 1 61  ? 21.07131  3.51851   17.32229  1.000 15.51515 ? 61  ARG B C   1 
ATOM   2361 O O   . ARG B 1 61  ? 19.96397  3.01982   17.51851  1.000 15.41440 ? 61  ARG B O   1 
ATOM   2362 C CB  . ARG B 1 61  ? 21.23313  5.03705   15.38052  1.000 21.10673 ? 61  ARG B CB  1 
ATOM   2363 C CG  . ARG B 1 61  ? 21.58215  5.27644   13.93814  1.000 28.75968 ? 61  ARG B CG  1 
ATOM   2364 C CD  . ARG B 1 61  ? 21.04243  6.63127   13.50746  1.000 35.76115 ? 61  ARG B CD  1 
ATOM   2365 N NE  . ARG B 1 61  ? 21.96032  7.71426   13.84224  1.000 37.47290 ? 61  ARG B NE  1 
ATOM   2366 C CZ  . ARG B 1 61  ? 22.76075  8.31375   12.96866  1.000 40.79509 ? 61  ARG B CZ  1 
ATOM   2367 N NH1 . ARG B 1 61  ? 22.78516  7.95824   11.69262  1.000 41.71392 ? 61  ARG B NH1 1 
ATOM   2368 N NH2 . ARG B 1 61  ? 23.54967  9.30019   13.38207  1.000 30.30637 ? 61  ARG B NH2 1 
ATOM   2369 N N   . PHE B 1 62  ? 21.85463  3.97640   18.29695  1.000 13.84166 ? 62  PHE B N   1 
ATOM   2370 C CA  . PHE B 1 62  ? 21.47297  3.91445   19.69765  1.000 12.09561 ? 62  PHE B CA  1 
ATOM   2371 C C   . PHE B 1 62  ? 21.63646  5.27705   20.33770  1.000 12.44441 ? 62  PHE B C   1 
ATOM   2372 O O   . PHE B 1 62  ? 22.55335  6.02828   20.00408  1.000 14.12707 ? 62  PHE B O   1 
ATOM   2373 C CB  . PHE B 1 62  ? 22.31879  2.90014   20.49611  1.000 13.17266 ? 62  PHE B CB  1 
ATOM   2374 C CG  . PHE B 1 62  ? 22.20678  1.49990   19.99946  1.000 11.39963 ? 62  PHE B CG  1 
ATOM   2375 C CD1 . PHE B 1 62  ? 23.05659  1.03698   19.00680  1.000 14.54483 ? 62  PHE B CD1 1 
ATOM   2376 C CD2 . PHE B 1 62  ? 21.27005  0.64248   20.53217  1.000 6.44155  ? 62  PHE B CD2 1 
ATOM   2377 C CE1 . PHE B 1 62  ? 22.95244  -0.26304  18.54488  1.000 17.24404 ? 62  PHE B CE1 1 
ATOM   2378 C CE2 . PHE B 1 62  ? 21.15034  -0.64822  20.07144  1.000 11.15817 ? 62  PHE B CE2 1 
ATOM   2379 C CZ  . PHE B 1 62  ? 21.99887  -1.10952  19.08241  1.000 13.03537 ? 62  PHE B CZ  1 
ATOM   2380 N N   . PHE B 1 63  ? 20.71317  5.57910   21.23992  1.000 11.08989 ? 63  PHE B N   1 
ATOM   2381 C CA  . PHE B 1 63  ? 20.84581  6.62815   22.23406  1.000 11.75678 ? 63  PHE B CA  1 
ATOM   2382 C C   . PHE B 1 63  ? 21.67765  6.06598   23.38530  1.000 13.00782 ? 63  PHE B C   1 
ATOM   2383 O O   . PHE B 1 63  ? 21.35737  4.99744   23.90789  1.000 13.55150 ? 63  PHE B O   1 
ATOM   2384 C CB  . PHE B 1 63  ? 19.43685  7.01380   22.69967  1.000 9.78289  ? 63  PHE B CB  1 
ATOM   2385 C CG  . PHE B 1 63  ? 19.37233  8.02895   23.82526  1.000 18.43952 ? 63  PHE B CG  1 
ATOM   2386 C CD1 . PHE B 1 63  ? 19.47965  7.62873   25.15269  1.000 14.86268 ? 63  PHE B CD1 1 
ATOM   2387 C CD2 . PHE B 1 63  ? 19.08142  9.36135   23.55530  1.000 18.68770 ? 63  PHE B CD2 1 
ATOM   2388 C CE1 . PHE B 1 63  ? 19.36365  8.53601   26.18093  1.000 15.52930 ? 63  PHE B CE1 1 
ATOM   2389 C CE2 . PHE B 1 63  ? 18.94934  10.28145  24.58279  1.000 17.04759 ? 63  PHE B CE2 1 
ATOM   2390 C CZ  . PHE B 1 63  ? 19.09157  9.86726   25.90075  1.000 19.84827 ? 63  PHE B CZ  1 
ATOM   2391 N N   . PHE B 1 64  ? 22.73640  6.77313   23.78052  1.000 15.44429 ? 64  PHE B N   1 
ATOM   2392 C CA  . PHE B 1 64  ? 23.66841  6.26215   24.77876  1.000 11.90907 ? 64  PHE B CA  1 
ATOM   2393 C C   . PHE B 1 64  ? 24.03502  7.36675   25.75691  1.000 13.75206 ? 64  PHE B C   1 
ATOM   2394 O O   . PHE B 1 64  ? 24.41966  8.45985   25.33958  1.000 12.74275 ? 64  PHE B O   1 
ATOM   2395 C CB  . PHE B 1 64  ? 24.91453  5.69558   24.06461  1.000 10.99976 ? 64  PHE B CB  1 
ATOM   2396 C CG  . PHE B 1 64  ? 26.06335  5.35851   24.97421  1.000 7.30188  ? 64  PHE B CG  1 
ATOM   2397 C CD1 . PHE B 1 64  ? 25.87626  4.56837   26.09153  1.000 8.20182  ? 64  PHE B CD1 1 
ATOM   2398 C CD2 . PHE B 1 64  ? 27.34674  5.77795   24.66053  1.000 11.26115 ? 64  PHE B CD2 1 
ATOM   2399 C CE1 . PHE B 1 64  ? 26.94141  4.23747   26.90391  1.000 10.43350 ? 64  PHE B CE1 1 
ATOM   2400 C CE2 . PHE B 1 64  ? 28.43182  5.44510   25.48135  1.000 10.77335 ? 64  PHE B CE2 1 
ATOM   2401 C CZ  . PHE B 1 64  ? 28.22523  4.67669   26.59205  1.000 9.83838  ? 64  PHE B CZ  1 
ATOM   2402 N N   . VAL B 1 65  ? 23.91546  7.10025   27.06455  1.000 13.97794 ? 65  VAL B N   1 
ATOM   2403 C CA  . VAL B 1 65  ? 24.39108  8.00926   28.08481  1.000 12.01709 ? 65  VAL B CA  1 
ATOM   2404 C C   . VAL B 1 65  ? 25.47998  7.27194   28.87321  1.000 12.03716 ? 65  VAL B C   1 
ATOM   2405 O O   . VAL B 1 65  ? 25.20598  6.25482   29.49954  1.000 10.11085 ? 65  VAL B O   1 
ATOM   2406 C CB  . VAL B 1 65  ? 23.27121  8.50207   29.03987  1.000 12.31472 ? 65  VAL B CB  1 
ATOM   2407 C CG1 . VAL B 1 65  ? 23.83836  9.48245   30.08320  1.000 11.31366 ? 65  VAL B CG1 1 
ATOM   2408 C CG2 . VAL B 1 65  ? 22.12066  9.18942   28.24592  1.000 11.91045 ? 65  VAL B CG2 1 
ATOM   2409 N N   . PRO B 1 66  ? 26.73402  7.72360   28.81109  1.000 11.29720 ? 66  PRO B N   1 
ATOM   2410 C CA  . PRO B 1 66  ? 27.80319  6.92450   29.43007  1.000 10.56006 ? 66  PRO B CA  1 
ATOM   2411 C C   . PRO B 1 66  ? 27.68751  6.75893   30.93420  1.000 12.55793 ? 66  PRO B C   1 
ATOM   2412 O O   . PRO B 1 66  ? 28.00791  5.67680   31.44594  1.000 12.93114 ? 66  PRO B O   1 
ATOM   2413 C CB  . PRO B 1 66  ? 29.06164  7.70202   29.02968  1.000 12.66074 ? 66  PRO B CB  1 
ATOM   2414 C CG  . PRO B 1 66  ? 28.71363  8.23463   27.69335  1.000 15.83688 ? 66  PRO B CG  1 
ATOM   2415 C CD  . PRO B 1 66  ? 27.27258  8.68620   27.83713  1.000 10.78348 ? 66  PRO B CD  1 
ATOM   2416 N N   A ARG B 1 67  ? 27.24124  7.79074   31.65796  0.323 11.68007 ? 67  ARG B N   1 
ATOM   2417 N N   B ARG B 1 67  ? 27.24328  7.78331   31.66658  0.677 11.68289 ? 67  ARG B N   1 
ATOM   2418 C CA  A ARG B 1 67  ? 27.27849  7.74934   33.11897  0.323 14.37573 ? 67  ARG B CA  1 
ATOM   2419 C CA  B ARG B 1 67  ? 27.28539  7.70626   33.12645  0.677 14.36397 ? 67  ARG B CA  1 
ATOM   2420 C C   A ARG B 1 67  ? 26.41900  6.61508   33.66318  0.323 12.75782 ? 67  ARG B C   1 
ATOM   2421 C C   B ARG B 1 67  ? 26.42751  6.56049   33.63698  0.677 12.82288 ? 67  ARG B C   1 
ATOM   2422 O O   A ARG B 1 67  ? 26.83435  5.88742   34.57369  0.323 12.81675 ? 67  ARG B O   1 
ATOM   2423 O O   B ARG B 1 67  ? 26.85176  5.77573   34.49568  0.677 12.73202 ? 67  ARG B O   1 
ATOM   2424 C CB  A ARG B 1 67  ? 26.82248  9.09396   33.69710  0.323 15.68915 ? 67  ARG B CB  1 
ATOM   2425 C CB  B ARG B 1 67  ? 26.83470  9.02844   33.75392  0.677 15.80160 ? 67  ARG B CB  1 
ATOM   2426 C CG  A ARG B 1 67  ? 27.64876  9.58703   34.90089  0.323 18.57961 ? 67  ARG B CG  1 
ATOM   2427 C CG  B ARG B 1 67  ? 26.73169  8.96247   35.30225  0.677 11.98700 ? 67  ARG B CG  1 
ATOM   2428 C CD  A ARG B 1 67  ? 28.63949  10.66430  34.46588  0.323 25.84132 ? 67  ARG B CD  1 
ATOM   2429 C CD  B ARG B 1 67  ? 27.99660  8.37921   35.95704  0.677 16.50521 ? 67  ARG B CD  1 
ATOM   2430 N NE  A ARG B 1 67  ? 29.51734  11.11252  35.53942  0.323 24.48248 ? 67  ARG B NE  1 
ATOM   2431 N NE  B ARG B 1 67  ? 27.86089  8.27100   37.41073  0.677 14.16768 ? 67  ARG B NE  1 
ATOM   2432 C CZ  A ARG B 1 67  ? 30.74004  10.64460  35.75045  0.323 21.60137 ? 67  ARG B CZ  1 
ATOM   2433 C CZ  B ARG B 1 67  ? 27.35849  7.22787   38.05977  0.677 15.81881 ? 67  ARG B CZ  1 
ATOM   2434 N NH1 A ARG B 1 67  ? 31.26568  9.70922   34.97681  0.323 18.36104 ? 67  ARG B NH1 1 
ATOM   2435 N NH1 B ARG B 1 67  ? 27.01508  6.11183   37.42647  0.677 12.18076 ? 67  ARG B NH1 1 
ATOM   2436 N NH2 A ARG B 1 67  ? 31.44924  11.11960  36.76978  0.323 33.09120 ? 67  ARG B NH2 1 
ATOM   2437 N NH2 B ARG B 1 67  ? 27.17561  7.31213   39.37813  0.677 13.40028 ? 67  ARG B NH2 1 
ATOM   2438 N N   . THR B 1 68  ? 25.22677  6.44041   33.10272  1.000 8.24591  ? 68  THR B N   1 
ATOM   2439 C CA  . THR B 1 68  ? 24.28028  5.43076   33.51639  1.000 9.66295  ? 68  THR B CA  1 
ATOM   2440 C C   . THR B 1 68  ? 24.36516  4.17180   32.67894  1.000 10.64199 ? 68  THR B C   1 
ATOM   2441 O O   . THR B 1 68  ? 23.72228  3.17913   33.02092  1.000 9.79883  ? 68  THR B O   1 
ATOM   2442 C CB  . THR B 1 68  ? 22.85794  5.98908   33.39443  1.000 14.11779 ? 68  THR B CB  1 
ATOM   2443 O OG1 . THR B 1 68  ? 22.65534  6.37888   32.03376  1.000 10.48103 ? 68  THR B OG1 1 
ATOM   2444 C CG2 . THR B 1 68  ? 22.65996  7.21319   34.30330  1.000 11.71423 ? 68  THR B CG2 1 
ATOM   2445 N N   . GLY B 1 69  ? 25.11018  4.20183   31.57416  1.000 11.80470 ? 69  GLY B N   1 
ATOM   2446 C CA  . GLY B 1 69  ? 25.08140  3.10392   30.64231  1.000 8.04123  ? 69  GLY B CA  1 
ATOM   2447 C C   . GLY B 1 69  ? 23.78956  2.97663   29.86819  1.000 10.88375 ? 69  GLY B C   1 
ATOM   2448 O O   . GLY B 1 69  ? 23.58280  1.95465   29.22580  1.000 10.39693 ? 69  GLY B O   1 
ATOM   2449 N N   . GLU B 1 70  ? 22.88893  3.96097   29.93904  1.000 9.52595  ? 70  GLU B N   1 
ATOM   2450 C CA  . GLU B 1 70  ? 21.62265  3.83285   29.23544  1.000 8.22294  ? 70  GLU B CA  1 
ATOM   2451 C C   . GLU B 1 70  ? 21.87743  3.67947   27.73794  1.000 10.70447 ? 70  GLU B C   1 
ATOM   2452 O O   . GLU B 1 70  ? 22.65887  4.42977   27.15450  1.000 9.57236  ? 70  GLU B O   1 
ATOM   2453 C CB  . GLU B 1 70  ? 20.74346  5.04654   29.50475  1.000 10.88073 ? 70  GLU B CB  1 
ATOM   2454 C CG  . GLU B 1 70  ? 19.37460  4.95637   28.83798  1.000 9.08199  ? 70  GLU B CG  1 
ATOM   2455 C CD  . GLU B 1 70  ? 18.49534  6.16910   29.12837  1.000 9.84088  ? 70  GLU B CD  1 
ATOM   2456 O OE1 . GLU B 1 70  ? 19.02135  7.19329   29.60226  1.000 16.02565 ? 70  GLU B OE1 1 
ATOM   2457 O OE2 . GLU B 1 70  ? 17.27621  6.08930   28.87904  1.000 12.60430 ? 70  GLU B OE2 1 
ATOM   2458 N N   . VAL B 1 71  ? 21.25646  2.66144   27.14042  1.000 10.47023 ? 71  VAL B N   1 
ATOM   2459 C CA  . VAL B 1 71  ? 21.32495  2.37504   25.70807  1.000 9.35613  ? 71  VAL B CA  1 
ATOM   2460 C C   . VAL B 1 71  ? 19.90008  2.11286   25.24558  1.000 11.86651 ? 71  VAL B C   1 
ATOM   2461 O O   . VAL B 1 71  ? 19.20921  1.26572   25.82061  1.000 11.14041 ? 71  VAL B O   1 
ATOM   2462 C CB  . VAL B 1 71  ? 22.22696  1.15843   25.40653  1.000 8.79348  ? 71  VAL B CB  1 
ATOM   2463 C CG1 . VAL B 1 71  ? 22.18794  0.79230   23.92515  1.000 8.81332  ? 71  VAL B CG1 1 
ATOM   2464 C CG2 . VAL B 1 71  ? 23.67144  1.44947   25.81878  1.000 6.55581  ? 71  VAL B CG2 1 
ATOM   2465 N N   . ARG B 1 72  ? 19.44332  2.86419   24.24224  1.000 14.38289 ? 72  ARG B N   1 
ATOM   2466 C CA  . ARG B 1 72  ? 18.11519  2.72011   23.65906  1.000 10.75332 ? 72  ARG B CA  1 
ATOM   2467 C C   . ARG B 1 72  ? 18.27977  2.60225   22.15217  1.000 9.80434  ? 72  ARG B C   1 
ATOM   2468 O O   . ARG B 1 72  ? 18.89713  3.46823   21.53610  1.000 9.05473  ? 72  ARG B O   1 
ATOM   2469 C CB  . ARG B 1 72  ? 17.21278  3.93259   23.96414  1.000 15.42701 ? 72  ARG B CB  1 
ATOM   2470 C CG  . ARG B 1 72  ? 17.00942  4.26903   25.43863  1.000 11.73535 ? 72  ARG B CG  1 
ATOM   2471 C CD  . ARG B 1 72  ? 16.34277  5.64734   25.58039  1.000 13.92195 ? 72  ARG B CD  1 
ATOM   2472 N NE  . ARG B 1 72  ? 15.11713  5.72883   24.79451  1.000 12.64688 ? 72  ARG B NE  1 
ATOM   2473 C CZ  . ARG B 1 72  ? 13.90876  5.41849   25.23889  1.000 15.82923 ? 72  ARG B CZ  1 
ATOM   2474 N NH1 . ARG B 1 72  ? 13.71168  4.98703   26.47449  1.000 16.15949 ? 72  ARG B NH1 1 
ATOM   2475 N NH2 . ARG B 1 72  ? 12.86767  5.55008   24.42460  1.000 19.17747 ? 72  ARG B NH2 1 
ATOM   2476 N N   . LEU B 1 73  ? 17.75106  1.53237   21.57184  1.000 11.66188 ? 73  LEU B N   1 
ATOM   2477 C CA  . LEU B 1 73  ? 17.72723  1.40870   20.12458  1.000 14.17299 ? 73  LEU B CA  1 
ATOM   2478 C C   . LEU B 1 73  ? 16.80718  2.47762   19.55189  1.000 22.70284 ? 73  LEU B C   1 
ATOM   2479 O O   . LEU B 1 73  ? 15.66422  2.61927   19.99486  1.000 15.94208 ? 73  LEU B O   1 
ATOM   2480 C CB  . LEU B 1 73  ? 17.23112  0.01806   19.72812  1.000 11.09474 ? 73  LEU B CB  1 
ATOM   2481 C CG  . LEU B 1 73  ? 16.98426  -0.26394  18.24391  1.000 17.84015 ? 73  LEU B CG  1 
ATOM   2482 C CD1 . LEU B 1 73  ? 18.30585  -0.40341  17.49094  1.000 14.02482 ? 73  LEU B CD1 1 
ATOM   2483 C CD2 . LEU B 1 73  ? 16.09807  -1.50244  18.06542  1.000 12.09447 ? 73  LEU B CD2 1 
ATOM   2484 N N   . ARG B 1 74  ? 17.31681  3.24733   18.57972  1.000 16.92899 ? 74  ARG B N   1 
ATOM   2485 C CA  . ARG B 1 74  ? 16.53726  4.31820   17.97669  1.000 19.11038 ? 74  ARG B CA  1 
ATOM   2486 C C   . ARG B 1 74  ? 15.75253  3.79294   16.77960  1.000 18.96796 ? 74  ARG B C   1 
ATOM   2487 O O   . ARG B 1 74  ? 16.09249  2.74767   16.21236  1.000 18.24933 ? 74  ARG B O   1 
ATOM   2488 C CB  . ARG B 1 74  ? 17.46641  5.46070   17.55667  1.000 20.04480 ? 74  ARG B CB  1 
ATOM   2489 C CG  . ARG B 1 74  ? 18.18817  6.12754   18.71309  1.000 19.56552 ? 74  ARG B CG  1 
ATOM   2490 C CD  . ARG B 1 74  ? 19.15754  7.22547   18.24890  1.000 19.75359 ? 74  ARG B CD  1 
ATOM   2491 N NE  . ARG B 1 74  ? 18.43647  8.32042   17.61655  1.000 28.60996 ? 74  ARG B NE  1 
ATOM   2492 C CZ  . ARG B 1 74  ? 18.99242  9.33874   16.97667  1.000 25.27682 ? 74  ARG B CZ  1 
ATOM   2493 N NH1 . ARG B 1 74  ? 20.30120  9.45219   16.86981  1.000 23.93938 ? 74  ARG B NH1 1 
ATOM   2494 N NH2 . ARG B 1 74  ? 18.20929  10.25807  16.41686  1.000 26.72536 ? 74  ARG B NH2 1 
ATOM   2495 N N   . PRO B 1 75  ? 14.65270  4.45702   16.40609  1.000 25.38690 ? 75  PRO B N   1 
ATOM   2496 C CA  . PRO B 1 75  ? 13.88546  4.00438   15.23865  1.000 24.81664 ? 75  PRO B CA  1 
ATOM   2497 C C   . PRO B 1 75  ? 14.80520  3.81004   14.04951  1.000 17.94134 ? 75  PRO B C   1 
ATOM   2498 O O   . PRO B 1 75  ? 15.69555  4.62271   13.79516  1.000 23.60514 ? 75  PRO B O   1 
ATOM   2499 C CB  . PRO B 1 75  ? 12.89304  5.14604   14.98961  1.000 27.60943 ? 75  PRO B CB  1 
ATOM   2500 C CG  . PRO B 1 75  ? 12.76793  5.83826   16.28011  1.000 28.92318 ? 75  PRO B CG  1 
ATOM   2501 C CD  . PRO B 1 75  ? 14.06634  5.65749   17.02228  1.000 19.86472 ? 75  PRO B CD  1 
ATOM   2502 N N   . HIS B 1 76  ? 14.59549  2.71405   13.33231  1.000 22.39763 ? 76  HIS B N   1 
ATOM   2503 C CA  . HIS B 1 76  ? 15.47552  2.38263   12.22131  1.000 26.66497 ? 76  HIS B CA  1 
ATOM   2504 C C   . HIS B 1 76  ? 15.19064  3.30162   11.03976  1.000 29.69362 ? 76  HIS B C   1 
ATOM   2505 O O   . HIS B 1 76  ? 14.13015  3.20974   10.41574  1.000 34.44709 ? 76  HIS B O   1 
ATOM   2506 C CB  . HIS B 1 76  ? 15.30638  0.92366   11.81301  1.000 18.81672 ? 76  HIS B CB  1 
ATOM   2507 C CG  . HIS B 1 76  ? 16.19077  0.53497   10.67217  1.000 23.73686 ? 76  HIS B CG  1 
ATOM   2508 N ND1 . HIS B 1 76  ? 17.55439  0.37596   10.80934  1.000 21.49759 ? 76  HIS B ND1 1 
ATOM   2509 C CD2 . HIS B 1 76  ? 15.91781  0.34430   9.35909   1.000 21.69232 ? 76  HIS B CD2 1 
ATOM   2510 C CE1 . HIS B 1 76  ? 18.07918  0.06685   9.63547   1.000 28.43724 ? 76  HIS B CE1 1 
ATOM   2511 N NE2 . HIS B 1 76  ? 17.10760  0.04361   8.74007   1.000 29.70748 ? 76  HIS B NE2 1 
ATOM   2512 N N   . ARG B 1 77  ? 16.12067  4.16097   10.71776  1.000 28.37689 ? 77  ARG B N   1 
ATOM   2513 C CA  . ARG B 1 77  ? 15.89483  4.99710   9.54500   1.000 42.17416 ? 77  ARG B CA  1 
ATOM   2514 C C   . ARG B 1 77  ? 16.42457  4.27455   8.30943   1.000 44.67534 ? 77  ARG B C   1 
ATOM   2515 O O   . ARG B 1 77  ? 17.56854  3.80183   8.32028   1.000 41.58318 ? 77  ARG B O   1 
ATOM   2516 C CB  . ARG B 1 77  ? 16.56971  6.35997   9.70882   1.000 34.94712 ? 77  ARG B CB  1 
ATOM   2517 C CG  . ARG B 1 77  ? 16.63501  6.88202   11.14837  1.000 52.73950 ? 77  ARG B CG  1 
ATOM   2518 C CD  . ARG B 1 77  ? 15.26493  7.25120   11.71397  1.000 50.80209 ? 77  ARG B CD  1 
ATOM   2519 N NE  . ARG B 1 77  ? 15.36534  7.80391   13.06262  1.000 60.23695 ? 77  ARG B NE  1 
ATOM   2520 C CZ  . ARG B 1 77  ? 15.49067  9.09611   13.34491  1.000 63.57793 ? 77  ARG B CZ  1 
ATOM   2521 N NH1 . ARG B 1 77  ? 15.52513  10.01598  12.38961  1.000 63.75233 ? 77  ARG B NH1 1 
ATOM   2522 N NH2 . ARG B 1 77  ? 15.57942  9.47651   14.61874  1.000 40.21073 ? 77  ARG B NH2 1 
ATOM   2523 N N   . PRO B 1 78  ? 15.64844  4.17918   7.23317   1.000 49.11894 ? 78  PRO B N   1 
ATOM   2524 C CA  . PRO B 1 78  ? 16.06751  3.34220   6.09768   1.000 41.63170 ? 78  PRO B CA  1 
ATOM   2525 C C   . PRO B 1 78  ? 17.20136  3.90484   5.25485   1.000 49.20919 ? 78  PRO B C   1 
ATOM   2526 O O   . PRO B 1 78  ? 17.53942  3.30982   4.22858   1.000 57.86402 ? 78  PRO B O   1 
ATOM   2527 C CB  . PRO B 1 78  ? 14.78549  3.22815   5.26324   1.000 42.57056 ? 78  PRO B CB  1 
ATOM   2528 C CG  . PRO B 1 78  ? 13.67782  3.61437   6.18514   1.000 43.53981 ? 78  PRO B CG  1 
ATOM   2529 C CD  . PRO B 1 78  ? 14.26656  4.65950   7.07706   1.000 44.71959 ? 78  PRO B CD  1 
ATOM   2530 N N   . TYR B 1 79  ? 17.79575  5.03097   5.65690   1.000 57.37450 ? 79  TYR B N   1 
ATOM   2531 C CA  . TYR B 1 79  ? 18.80674  5.72022   4.84842   1.000 48.17140 ? 79  TYR B CA  1 
ATOM   2532 C C   . TYR B 1 79  ? 19.90256  6.22629   5.78444   1.000 58.80445 ? 79  TYR B C   1 
ATOM   2533 O O   . TYR B 1 79  ? 19.69540  7.19330   6.52378   1.000 49.46135 ? 79  TYR B O   1 
ATOM   2534 C CB  . TYR B 1 79  ? 18.17489  6.86058   4.05337   1.000 46.33415 ? 79  TYR B CB  1 
ATOM   2535 C CG  . TYR B 1 79  ? 19.15498  7.76408   3.32614   1.000 52.96923 ? 79  TYR B CG  1 
ATOM   2536 C CD1 . TYR B 1 79  ? 19.61929  7.45050   2.05429   1.000 49.61011 ? 79  TYR B CD1 1 
ATOM   2537 C CD2 . TYR B 1 79  ? 19.60035  8.94562   3.90985   1.000 58.50564 ? 79  TYR B CD2 1 
ATOM   2538 C CE1 . TYR B 1 79  ? 20.51147  8.28455   1.39149   1.000 52.07552 ? 79  TYR B CE1 1 
ATOM   2539 C CE2 . TYR B 1 79  ? 20.48805  9.78095   3.26183   1.000 50.19156 ? 79  TYR B CE2 1 
ATOM   2540 C CZ  . TYR B 1 79  ? 20.94174  9.45136   2.00210   1.000 59.04118 ? 79  TYR B CZ  1 
ATOM   2541 O OH  . TYR B 1 79  ? 21.82796  10.29520  1.35630   1.000 62.31494 ? 79  TYR B OH  1 
ATOM   2542 N N   . PHE B 1 80  ? 21.06197  5.57358   5.75829   1.000 60.90458 ? 80  PHE B N   1 
ATOM   2543 C CA  . PHE B 1 80  ? 22.13401  5.90275   6.69831   1.000 59.14398 ? 80  PHE B CA  1 
ATOM   2544 C C   . PHE B 1 80  ? 22.78813  7.22930   6.32365   1.000 64.72521 ? 80  PHE B C   1 
ATOM   2545 O O   . PHE B 1 80  ? 22.29495  8.30091   6.69419   1.000 61.77209 ? 80  PHE B O   1 
ATOM   2546 C CB  . PHE B 1 80  ? 23.16036  4.75216   6.75523   1.000 56.95853 ? 80  PHE B CB  1 
ATOM   2547 C CG  . PHE B 1 80  ? 24.58745  5.19140   6.99705   1.000 55.52750 ? 80  PHE B CG  1 
ATOM   2548 C CD1 . PHE B 1 80  ? 24.95426  5.84786   8.16366   1.000 54.15931 ? 80  PHE B CD1 1 
ATOM   2549 C CD2 . PHE B 1 80  ? 25.57061  4.90797   6.06200   1.000 53.65314 ? 80  PHE B CD2 1 
ATOM   2550 C CE1 . PHE B 1 80  ? 26.27185  6.24031   8.37341   1.000 56.90762 ? 80  PHE B CE1 1 
ATOM   2551 C CE2 . PHE B 1 80  ? 26.88087  5.29224   6.26888   1.000 47.11266 ? 80  PHE B CE2 1 
ATOM   2552 C CZ  . PHE B 1 80  ? 27.23357  5.95693   7.42222   1.000 55.41701 ? 80  PHE B CZ  1 
ATOM   2553 N N   . ASP B 1 95  ? 18.68335  1.36395   0.92432   1.000 46.46215 ? 95  ASP B N   1 
ATOM   2554 C CA  . ASP B 1 95  ? 17.93587  0.78190   2.03294   1.000 40.86752 ? 95  ASP B CA  1 
ATOM   2555 C C   . ASP B 1 95  ? 18.76382  -0.25541  2.79027   1.000 41.78184 ? 95  ASP B C   1 
ATOM   2556 O O   . ASP B 1 95  ? 18.80129  -1.42736  2.41219   1.000 38.66650 ? 95  ASP B O   1 
ATOM   2557 C CB  . ASP B 1 95  ? 16.64144  0.14542   1.53088   1.000 46.57717 ? 95  ASP B CB  1 
ATOM   2558 C CG  . ASP B 1 95  ? 15.41531  0.97359   1.86687   1.000 61.63750 ? 95  ASP B CG  1 
ATOM   2559 O OD1 . ASP B 1 95  ? 15.18267  2.00943   1.19827   1.000 49.80189 ? 95  ASP B OD1 1 
ATOM   2560 O OD2 . ASP B 1 95  ? 14.68188  0.58444   2.80391   1.000 62.39597 ? 95  ASP B OD2 1 
ATOM   2561 N N   . VAL B 1 96  ? 19.42895  0.18209   3.85814   1.000 45.94476 ? 96  VAL B N   1 
ATOM   2562 C CA  . VAL B 1 96  ? 20.18945  -0.72633  4.71067   1.000 33.29331 ? 96  VAL B CA  1 
ATOM   2563 C C   . VAL B 1 96  ? 19.24233  -1.39398  5.70084   1.000 27.00303 ? 96  VAL B C   1 
ATOM   2564 O O   . VAL B 1 96  ? 18.36795  -0.74834  6.29894   1.000 31.86321 ? 96  VAL B O   1 
ATOM   2565 C CB  . VAL B 1 96  ? 21.32754  0.02473   5.42725   1.000 37.84049 ? 96  VAL B CB  1 
ATOM   2566 C CG1 . VAL B 1 96  ? 22.26188  0.66165   4.41628   1.000 44.60861 ? 96  VAL B CG1 1 
ATOM   2567 C CG2 . VAL B 1 96  ? 20.76918  1.09572   6.33821   1.000 48.31555 ? 96  VAL B CG2 1 
ATOM   2568 N N   . ALA B 1 97  ? 19.39399  -2.69902  5.86248   1.000 22.88305 ? 97  ALA B N   1 
ATOM   2569 C CA  . ALA B 1 97  ? 18.54825  -3.43540  6.78231   1.000 25.13940 ? 97  ALA B CA  1 
ATOM   2570 C C   . ALA B 1 97  ? 18.92235  -3.13405  8.23704   1.000 23.71130 ? 97  ALA B C   1 
ATOM   2571 O O   . ALA B 1 97  ? 20.02736  -2.65983  8.53183   1.000 19.73523 ? 97  ALA B O   1 
ATOM   2572 C CB  . ALA B 1 97  ? 18.65847  -4.93252  6.50846   1.000 23.87615 ? 97  ALA B CB  1 
ATOM   2573 N N   . PRO B 1 98  ? 18.00453  -3.38442  9.16238   1.000 23.18264 ? 98  PRO B N   1 
ATOM   2574 C CA  . PRO B 1 98  ? 18.33058  -3.26254  10.58668  1.000 23.97191 ? 98  PRO B CA  1 
ATOM   2575 C C   . PRO B 1 98  ? 19.23116  -4.39779  11.03260  1.000 29.53299 ? 98  PRO B C   1 
ATOM   2576 O O   . PRO B 1 98  ? 19.40414  -5.39994  10.33815  1.000 24.32682 ? 98  PRO B O   1 
ATOM   2577 C CB  . PRO B 1 98  ? 16.97154  -3.35361  11.27887  1.000 22.79722 ? 98  PRO B CB  1 
ATOM   2578 C CG  . PRO B 1 98  ? 15.94511  -3.21876  10.18779  1.000 35.67034 ? 98  PRO B CG  1 
ATOM   2579 C CD  . PRO B 1 98  ? 16.58728  -3.71445  8.94912   1.000 32.10877 ? 98  PRO B CD  1 
ATOM   2580 N N   . LEU B 1 99  ? 19.80409  -4.22868  12.22277  1.000 22.29872 ? 99  LEU B N   1 
ATOM   2581 C CA  . LEU B 1 99  ? 20.50449  -5.33206  12.85651  1.000 17.34267 ? 99  LEU B CA  1 
ATOM   2582 C C   . LEU B 1 99  ? 19.51732  -6.45173  13.14633  1.000 21.21755 ? 99  LEU B C   1 
ATOM   2583 O O   . LEU B 1 99  ? 18.36772  -6.21139  13.53171  1.000 25.00359 ? 99  LEU B O   1 
ATOM   2584 C CB  . LEU B 1 99  ? 21.17282  -4.85939  14.14704  1.000 14.11785 ? 99  LEU B CB  1 
ATOM   2585 C CG  . LEU B 1 99  ? 22.13005  -3.66999  14.03740  1.000 12.71708 ? 99  LEU B CG  1 
ATOM   2586 C CD1 . LEU B 1 99  ? 22.61429  -3.29431  15.44485  1.000 14.35674 ? 99  LEU B CD1 1 
ATOM   2587 C CD2 . LEU B 1 99  ? 23.30943  -3.98824  13.09257  1.000 13.92389 ? 99  LEU B CD2 1 
ATOM   2588 N N   . SER B 1 100 ? 19.96263  -7.68246  12.94763  1.000 25.21585 ? 100 SER B N   1 
ATOM   2589 C CA  . SER B 1 100 ? 19.07623  -8.82050  13.10178  1.000 20.86212 ? 100 SER B CA  1 
ATOM   2590 C C   . SER B 1 100 ? 18.56025  -8.92139  14.52767  1.000 23.65570 ? 100 SER B C   1 
ATOM   2591 O O   . SER B 1 100 ? 19.09860  -8.32074  15.46647  1.000 22.87840 ? 100 SER B O   1 
ATOM   2592 C CB  . SER B 1 100 ? 19.78754  -10.12539 12.73991  1.000 25.74369 ? 100 SER B CB  1 
ATOM   2593 O OG  . SER B 1 100 ? 20.50615  -10.63206 13.85245  1.000 26.28947 ? 100 SER B OG  1 
ATOM   2594 N N   A ARG B 1 101 ? 17.49798  -9.71244  14.67963  0.524 23.24908 ? 101 ARG B N   1 
ATOM   2595 N N   B ARG B 1 101 ? 17.49940  -9.71381  14.68356  0.476 23.27892 ? 101 ARG B N   1 
ATOM   2596 C CA  A ARG B 1 101 ? 16.90304  -9.93280  15.99247  0.524 29.01079 ? 101 ARG B CA  1 
ATOM   2597 C CA  B ARG B 1 101 ? 16.91108  -9.92376  16.00112  0.476 28.98419 ? 101 ARG B CA  1 
ATOM   2598 C C   A ARG B 1 101 ? 17.89319  -10.59631 16.94501  0.524 24.22483 ? 101 ARG B C   1 
ATOM   2599 C C   B ARG B 1 101 ? 17.90203  -10.59143 16.94799  0.476 24.22329 ? 101 ARG B C   1 
ATOM   2600 O O   A ARG B 1 101 ? 17.99742  -10.21043 18.11494  0.524 21.59835 ? 101 ARG B O   1 
ATOM   2601 O O   B ARG B 1 101 ? 18.01387  -10.20578 18.11727  0.476 21.62558 ? 101 ARG B O   1 
ATOM   2602 C CB  A ARG B 1 101 ? 15.64137  -10.78452 15.83735  0.524 28.72300 ? 101 ARG B CB  1 
ATOM   2603 C CB  B ARG B 1 101 ? 15.64237  -10.76614 15.86589  0.476 28.74175 ? 101 ARG B CB  1 
ATOM   2604 C CG  A ARG B 1 101 ? 14.42052  -10.23056 16.53016  0.524 35.90773 ? 101 ARG B CG  1 
ATOM   2605 C CG  B ARG B 1 101 ? 14.47641  -10.26653 16.68448  0.476 35.76295 ? 101 ARG B CG  1 
ATOM   2606 C CD  A ARG B 1 101 ? 14.08228  -11.06724 17.73901  0.524 39.83461 ? 101 ARG B CD  1 
ATOM   2607 C CD  B ARG B 1 101 ? 14.13026  -11.23594 17.78992  0.476 39.80527 ? 101 ARG B CD  1 
ATOM   2608 N NE  A ARG B 1 101 ? 12.74973  -11.65282 17.65062  0.524 37.74942 ? 101 ARG B NE  1 
ATOM   2609 N NE  B ARG B 1 101 ? 14.58763  -10.77674 19.09557  0.476 33.19112 ? 101 ARG B NE  1 
ATOM   2610 C CZ  A ARG B 1 101 ? 11.67778  -11.15385 18.24874  0.524 37.78108 ? 101 ARG B CZ  1 
ATOM   2611 C CZ  B ARG B 1 101 ? 14.20103  -11.31047 20.24433  0.476 29.77152 ? 101 ARG B CZ  1 
ATOM   2612 N NH1 A ARG B 1 101 ? 11.73915  -10.03489 18.95221  0.524 36.16573 ? 101 ARG B NH1 1 
ATOM   2613 N NH1 B ARG B 1 101 ? 13.34769  -12.32155 20.28233  0.476 38.18516 ? 101 ARG B NH1 1 
ATOM   2614 N NH2 A ARG B 1 101 ? 10.51861  -11.79749 18.14518  0.524 33.89575 ? 101 ARG B NH2 1 
ATOM   2615 N NH2 B ARG B 1 101 ? 14.67751  -10.81594 21.38184  0.476 28.72742 ? 101 ARG B NH2 1 
ATOM   2616 N N   . THR B 1 102 ? 18.63574  -11.59392 16.45974  1.000 24.29572 ? 102 THR B N   1 
ATOM   2617 C CA  . THR B 1 102 ? 19.57240  -12.29804 17.32643  1.000 20.92413 ? 102 THR B CA  1 
ATOM   2618 C C   . THR B 1 102 ? 20.82136  -11.47249 17.59178  1.000 22.86120 ? 102 THR B C   1 
ATOM   2619 O O   . THR B 1 102 ? 21.46611  -11.65791 18.62889  1.000 26.87168 ? 102 THR B O   1 
ATOM   2620 C CB  . THR B 1 102 ? 19.94603  -13.64954 16.72104  1.000 21.13594 ? 102 THR B CB  1 
ATOM   2621 O OG1 . THR B 1 102 ? 20.01601  -13.52185 15.29301  1.000 31.93596 ? 102 THR B OG1 1 
ATOM   2622 C CG2 . THR B 1 102 ? 18.92706  -14.70218 17.09606  1.000 27.21823 ? 102 THR B CG2 1 
ATOM   2623 N N   . THR B 1 103 ? 21.18421  -10.57490 16.66930  1.000 25.01145 ? 103 THR B N   1 
ATOM   2624 C CA  . THR B 1 103 ? 22.21939  -9.58463  16.96251  1.000 22.06169 ? 103 THR B CA  1 
ATOM   2625 C C   . THR B 1 103 ? 21.82882  -8.71918  18.15306  1.000 20.49408 ? 103 THR B C   1 
ATOM   2626 O O   . THR B 1 103 ? 22.58155  -8.59356  19.12118  1.000 15.63531 ? 103 THR B O   1 
ATOM   2627 C CB  . THR B 1 103 ? 22.46361  -8.69736  15.74784  1.000 20.85155 ? 103 THR B CB  1 
ATOM   2628 O OG1 . THR B 1 103 ? 22.97192  -9.48455  14.66550  1.000 18.34484 ? 103 THR B OG1 1 
ATOM   2629 C CG2 . THR B 1 103 ? 23.44358  -7.58896  16.10843  1.000 18.21847 ? 103 THR B CG2 1 
ATOM   2630 N N   . LEU B 1 104 ? 20.65425  -8.09186  18.08402  1.000 20.65951 ? 104 LEU B N   1 
ATOM   2631 C CA  . LEU B 1 104 ? 20.20135  -7.22641  19.16491  1.000 16.28624 ? 104 LEU B CA  1 
ATOM   2632 C C   . LEU B 1 104 ? 19.97867  -7.99994  20.45951  1.000 21.90679 ? 104 LEU B C   1 
ATOM   2633 O O   . LEU B 1 104 ? 20.09726  -7.43001  21.55002  1.000 23.55087 ? 104 LEU B O   1 
ATOM   2634 C CB  . LEU B 1 104 ? 18.91782  -6.50612  18.73060  1.000 16.67313 ? 104 LEU B CB  1 
ATOM   2635 C CG  . LEU B 1 104 ? 19.15248  -5.48025  17.61122  1.000 19.14949 ? 104 LEU B CG  1 
ATOM   2636 C CD1 . LEU B 1 104 ? 17.85781  -5.08942  16.91516  1.000 21.29134 ? 104 LEU B CD1 1 
ATOM   2637 C CD2 . LEU B 1 104 ? 19.81871  -4.25418  18.18823  1.000 17.00061 ? 104 LEU B CD2 1 
ATOM   2638 N N   . ALA B 1 105 ? 19.64653  -9.28934  20.36816  1.000 19.12535 ? 105 ALA B N   1 
ATOM   2639 C CA  . ALA B 1 105 ? 19.43857  -10.08592 21.56786  1.000 19.48251 ? 105 ALA B CA  1 
ATOM   2640 C C   . ALA B 1 105 ? 20.74416  -10.56757 22.18523  1.000 26.14589 ? 105 ALA B C   1 
ATOM   2641 O O   . ALA B 1 105 ? 20.73544  -11.03892 23.32403  1.000 23.55850 ? 105 ALA B O   1 
ATOM   2642 C CB  . ALA B 1 105 ? 18.53135  -11.27660 21.25415  1.000 19.28309 ? 105 ALA B CB  1 
ATOM   2643 N N   . ASN B 1 106 ? 21.85689  -10.44130 21.48118  1.000 20.20151 ? 106 ASN B N   1 
ATOM   2644 C CA  . ASN B 1 106 ? 23.14795  -10.87261 22.02670  1.000 16.43646 ? 106 ASN B CA  1 
ATOM   2645 C C   . ASN B 1 106 ? 23.67944  -9.84529  23.02024  1.000 20.11673 ? 106 ASN B C   1 
ATOM   2646 O O   . ASN B 1 106 ? 23.93398  -8.69562  22.63155  1.000 17.47632 ? 106 ASN B O   1 
ATOM   2647 C CB  . ASN B 1 106 ? 24.11853  -11.07503 20.86701  1.000 14.59161 ? 106 ASN B CB  1 
ATOM   2648 C CG  . ASN B 1 106 ? 25.40181  -11.75755 21.28164  1.000 16.13873 ? 106 ASN B CG  1 
ATOM   2649 O OD1 . ASN B 1 106 ? 25.90176  -11.56406 22.39344  1.000 17.05037 ? 106 ASN B OD1 1 
ATOM   2650 N ND2 . ASN B 1 106 ? 25.95685  -12.54511 20.37516  1.000 16.60653 ? 106 ASN B ND2 1 
ATOM   2651 N N   . PRO B 1 107 ? 23.89120  -10.19758 24.29122  1.000 18.23344 ? 107 PRO B N   1 
ATOM   2652 C CA  . PRO B 1 107 ? 24.37921  -9.20464  25.25960  1.000 17.69397 ? 107 PRO B CA  1 
ATOM   2653 C C   . PRO B 1 107 ? 25.71643  -8.59686  24.90603  1.000 19.21225 ? 107 PRO B C   1 
ATOM   2654 O O   . PRO B 1 107 ? 26.04183  -7.52167  25.42647  1.000 13.42589 ? 107 PRO B O   1 
ATOM   2655 C CB  . PRO B 1 107 ? 24.48775  -9.99986  26.56299  1.000 16.94145 ? 107 PRO B CB  1 
ATOM   2656 C CG  . PRO B 1 107 ? 24.61744  -11.41640 26.11672  1.000 18.52132 ? 107 PRO B CG  1 
ATOM   2657 C CD  . PRO B 1 107 ? 23.73024  -11.52593 24.91260  1.000 18.92396 ? 107 PRO B CD  1 
ATOM   2658 N N   . LEU B 1 108 ? 26.50456  -9.25662  24.05723  1.000 12.58804 ? 108 LEU B N   1 
ATOM   2659 C CA  . LEU B 1 108 ? 27.83808  -8.76504  23.74634  1.000 15.69137 ? 108 LEU B CA  1 
ATOM   2660 C C   . LEU B 1 108 ? 27.79270  -7.43393  23.01305  1.000 8.70071  ? 108 LEU B C   1 
ATOM   2661 O O   . LEU B 1 108 ? 28.69891  -6.61726  23.16043  1.000 9.19652  ? 108 LEU B O   1 
ATOM   2662 C CB  . LEU B 1 108 ? 28.59068  -9.80964  22.90784  1.000 11.64635 ? 108 LEU B CB  1 
ATOM   2663 C CG  . LEU B 1 108 ? 29.98700  -9.38367  22.46126  1.000 13.96100 ? 108 LEU B CG  1 
ATOM   2664 C CD1 . LEU B 1 108 ? 30.82730  -9.01802  23.66576  1.000 17.41731 ? 108 LEU B CD1 1 
ATOM   2665 C CD2 . LEU B 1 108 ? 30.64648  -10.48252 21.64439  1.000 15.66436 ? 108 LEU B CD2 1 
ATOM   2666 N N   . LEU B 1 109 ? 26.75175  -7.17640  22.23335  1.000 8.81257  ? 109 LEU B N   1 
ATOM   2667 C CA  . LEU B 1 109 ? 26.76332  -5.96016  21.41817  1.000 12.94703 ? 109 LEU B CA  1 
ATOM   2668 C C   . LEU B 1 109 ? 26.79375  -4.70322  22.28445  1.000 10.15655 ? 109 LEU B C   1 
ATOM   2669 O O   . LEU B 1 109 ? 27.64188  -3.82008  22.09910  1.000 11.25815 ? 109 LEU B O   1 
ATOM   2670 C CB  . LEU B 1 109 ? 25.54935  -5.93712  20.49506  1.000 9.68887  ? 109 LEU B CB  1 
ATOM   2671 C CG  . LEU B 1 109 ? 25.54722  -4.80563  19.46407  1.000 9.16509  ? 109 LEU B CG  1 
ATOM   2672 C CD1 . LEU B 1 109 ? 26.49252  -5.08778  18.29384  1.000 14.91968 ? 109 LEU B CD1 1 
ATOM   2673 C CD2 . LEU B 1 109 ? 24.12028  -4.55955  18.97352  1.000 18.82582 ? 109 LEU B CD2 1 
ATOM   2674 N N   . THR B 1 110 ? 25.84985  -4.58057  23.21878  1.000 11.49598 ? 110 THR B N   1 
ATOM   2675 C CA  . THR B 1 110 ? 25.85271  -3.38410  24.05364  1.000 10.58872 ? 110 THR B CA  1 
ATOM   2676 C C   . THR B 1 110 ? 26.97526  -3.41914  25.08044  1.000 9.49002  ? 110 THR B C   1 
ATOM   2677 O O   . THR B 1 110 ? 27.41330  -2.35598  25.52634  1.000 7.56386  ? 110 THR B O   1 
ATOM   2678 C CB  . THR B 1 110 ? 24.51216  -3.17104  24.77789  1.000 14.75245 ? 110 THR B CB  1 
ATOM   2679 O OG1 . THR B 1 110 ? 24.21520  -4.29203  25.62708  1.000 19.18503 ? 110 THR B OG1 1 
ATOM   2680 C CG2 . THR B 1 110 ? 23.37696  -2.95097  23.77639  1.000 14.63770 ? 110 THR B CG2 1 
ATOM   2681 N N   . ARG B 1 111 ? 27.47656  -4.60132  25.44102  1.000 8.33593  ? 111 ARG B N   1 
ATOM   2682 C CA  . ARG B 1 111 ? 28.63637  -4.62713  26.33524  1.000 13.22800 ? 111 ARG B CA  1 
ATOM   2683 C C   . ARG B 1 111 ? 29.87167  -4.07957  25.65131  1.000 9.66402  ? 111 ARG B C   1 
ATOM   2684 O O   . ARG B 1 111 ? 30.66295  -3.36857  26.27634  1.000 8.04874  ? 111 ARG B O   1 
ATOM   2685 C CB  . ARG B 1 111 ? 28.89942  -6.04036  26.84940  1.000 16.86784 ? 111 ARG B CB  1 
ATOM   2686 C CG  . ARG B 1 111 ? 27.80884  -6.48568  27.81279  1.000 22.82795 ? 111 ARG B CG  1 
ATOM   2687 C CD  . ARG B 1 111 ? 27.95972  -7.92151  28.25198  1.000 23.88255 ? 111 ARG B CD  1 
ATOM   2688 N NE  . ARG B 1 111 ? 27.11077  -8.18903  29.40924  1.000 24.41984 ? 111 ARG B NE  1 
ATOM   2689 C CZ  . ARG B 1 111 ? 26.77976  -9.40319  29.82870  1.000 28.45797 ? 111 ARG B CZ  1 
ATOM   2690 N NH1 . ARG B 1 111 ? 27.19756  -10.48752 29.19536  1.000 28.34040 ? 111 ARG B NH1 1 
ATOM   2691 N NH2 . ARG B 1 111 ? 25.98736  -9.53045  30.89196  1.000 26.17534 ? 111 ARG B NH2 1 
ATOM   2692 N N   . LEU B 1 112 ? 30.07653  -4.42982  24.37438  1.000 9.99757  ? 112 LEU B N   1 
ATOM   2693 C CA  . LEU B 1 112 ? 31.14169  -3.79184  23.60513  1.000 15.68730 ? 112 LEU B CA  1 
ATOM   2694 C C   . LEU B 1 112 ? 30.88626  -2.29744  23.43857  1.000 11.49381 ? 112 LEU B C   1 
ATOM   2695 O O   . LEU B 1 112 ? 31.81095  -1.48374  23.54918  1.000 8.89744  ? 112 LEU B O   1 
ATOM   2696 C CB  . LEU B 1 112 ? 31.25694  -4.43990  22.22651  1.000 10.24575 ? 112 LEU B CB  1 
ATOM   2697 C CG  . LEU B 1 112 ? 31.88921  -5.81760  22.13096  1.000 13.33810 ? 112 LEU B CG  1 
ATOM   2698 C CD1 . LEU B 1 112 ? 31.72683  -6.34250  20.69141  1.000 11.33236 ? 112 LEU B CD1 1 
ATOM   2699 C CD2 . LEU B 1 112 ? 33.34905  -5.71705  22.55794  1.000 13.93138 ? 112 LEU B CD2 1 
ATOM   2700 N N   . LEU B 1 113 ? 29.64466  -1.92118  23.12779  1.000 11.17161 ? 113 LEU B N   1 
ATOM   2701 C CA  . LEU B 1 113 ? 29.32757  -0.50220  23.01828  1.000 7.68134  ? 113 LEU B CA  1 
ATOM   2702 C C   . LEU B 1 113 ? 29.80912  0.25420   24.25541  1.000 8.19023  ? 113 LEU B C   1 
ATOM   2703 O O   . LEU B 1 113 ? 30.49921  1.26575   24.13450  1.000 11.26686 ? 113 LEU B O   1 
ATOM   2704 C CB  . LEU B 1 113 ? 27.82197  -0.30744  22.78190  1.000 7.18934  ? 113 LEU B CB  1 
ATOM   2705 C CG  . LEU B 1 113 ? 27.35279  1.13234   22.47540  1.000 13.76318 ? 113 LEU B CG  1 
ATOM   2706 C CD1 . LEU B 1 113 ? 26.07940  1.15129   21.64023  1.000 16.38025 ? 113 LEU B CD1 1 
ATOM   2707 C CD2 . LEU B 1 113 ? 27.12343  1.97007   23.75748  1.000 12.53167 ? 113 LEU B CD2 1 
ATOM   2708 N N   . ARG B 1 114 ? 29.47178  -0.23115  25.46257  1.000 8.78844  ? 114 ARG B N   1 
ATOM   2709 C CA  . ARG B 1 114 ? 29.86733  0.49751   26.67323  1.000 10.95642 ? 114 ARG B CA  1 
ATOM   2710 C C   . ARG B 1 114 ? 31.36372  0.37526   26.92587  1.000 10.24601 ? 114 ARG B C   1 
ATOM   2711 O O   . ARG B 1 114 ? 32.03757  1.35462   27.26861  1.000 14.40454 ? 114 ARG B O   1 
ATOM   2712 C CB  . ARG B 1 114 ? 29.08811  -0.01612  27.89320  1.000 11.84009 ? 114 ARG B CB  1 
ATOM   2713 C CG  . ARG B 1 114 ? 27.55572  0.15371   27.77540  1.000 7.27691  ? 114 ARG B CG  1 
ATOM   2714 C CD  . ARG B 1 114 ? 26.85384  -0.19877  29.10834  1.000 7.50123  ? 114 ARG B CD  1 
ATOM   2715 N NE  . ARG B 1 114 ? 25.40120  -0.18025  28.94398  1.000 8.80445  ? 114 ARG B NE  1 
ATOM   2716 C CZ  . ARG B 1 114 ? 24.68065  -1.23868  28.60816  1.000 11.69104 ? 114 ARG B CZ  1 
ATOM   2717 N NH1 . ARG B 1 114 ? 25.23853  -2.43402  28.45776  1.000 16.75322 ? 114 ARG B NH1 1 
ATOM   2718 N NH2 . ARG B 1 114 ? 23.38039  -1.08689  28.36879  1.000 12.54589 ? 114 ARG B NH2 1 
ATOM   2719 N N   . ALA B 1 115 ? 31.90630  -0.82936  26.78844  1.000 15.06880 ? 115 ALA B N   1 
ATOM   2720 C CA  . ALA B 1 115 ? 33.32734  -1.00116  27.08376  1.000 16.35960 ? 115 ALA B CA  1 
ATOM   2721 C C   . ALA B 1 115 ? 34.20195  -0.21410  26.11721  1.000 13.01672 ? 115 ALA B C   1 
ATOM   2722 O O   . ALA B 1 115 ? 35.19422  0.40865   26.52659  1.000 11.91067 ? 115 ALA B O   1 
ATOM   2723 C CB  . ALA B 1 115 ? 33.69104  -2.48498  27.05999  1.000 17.39293 ? 115 ALA B CB  1 
ATOM   2724 N N   . ASP B 1 116 ? 33.87295  -0.23837  24.82185  1.000 13.32864 ? 116 ASP B N   1 
ATOM   2725 C CA  . ASP B 1 116 ? 34.71508  0.47865   23.86815  1.000 12.21959 ? 116 ASP B CA  1 
ATOM   2726 C C   . ASP B 1 116 ? 34.78751  1.95105   24.22538  1.000 11.94675 ? 116 ASP B C   1 
ATOM   2727 O O   . ASP B 1 116 ? 35.86544  2.55534   24.19661  1.000 12.66270 ? 116 ASP B O   1 
ATOM   2728 C CB  . ASP B 1 116 ? 34.19123  0.31072   22.43275  1.000 8.14391  ? 116 ASP B CB  1 
ATOM   2729 C CG  . ASP B 1 116 ? 34.28547  -1.11340  21.93233  1.000 12.56523 ? 116 ASP B CG  1 
ATOM   2730 O OD1 . ASP B 1 116 ? 35.12211  -1.89469  22.44826  1.000 14.01831 ? 116 ASP B OD1 1 
ATOM   2731 O OD2 . ASP B 1 116 ? 33.52037  -1.46131  21.01038  1.000 12.33287 ? 116 ASP B OD2 1 
ATOM   2732 N N   . PHE B 1 117 ? 33.65255  2.53000   24.62284  1.000 14.35786 ? 117 PHE B N   1 
ATOM   2733 C CA  . PHE B 1 117 ? 33.61820  3.94874   24.93662  1.000 14.76994 ? 117 PHE B CA  1 
ATOM   2734 C C   . PHE B 1 117 ? 34.62175  4.33198   26.02534  1.000 14.87250 ? 117 PHE B C   1 
ATOM   2735 O O   . PHE B 1 117 ? 35.16958  5.44310   26.00238  1.000 15.56169 ? 117 PHE B O   1 
ATOM   2736 C CB  . PHE B 1 117 ? 32.21290  4.34239   25.36208  1.000 14.88948 ? 117 PHE B CB  1 
ATOM   2737 C CG  . PHE B 1 117 ? 32.08596  5.78102   25.66947  1.000 15.37921 ? 117 PHE B CG  1 
ATOM   2738 C CD1 . PHE B 1 117 ? 31.81285  6.69033   24.65391  1.000 16.63319 ? 117 PHE B CD1 1 
ATOM   2739 C CD2 . PHE B 1 117 ? 32.25978  6.24145   26.96937  1.000 17.56143 ? 117 PHE B CD2 1 
ATOM   2740 C CE1 . PHE B 1 117 ? 31.70370  8.04133   24.93132  1.000 19.39690 ? 117 PHE B CE1 1 
ATOM   2741 C CE2 . PHE B 1 117 ? 32.16763  7.58473   27.24842  1.000 21.11758 ? 117 PHE B CE2 1 
ATOM   2742 C CZ  . PHE B 1 117 ? 31.88671  8.48907   26.22518  1.000 18.86749 ? 117 PHE B CZ  1 
ATOM   2743 N N   . GLU B 1 118 ? 34.86817  3.43968   26.98338  1.000 12.09630 ? 118 GLU B N   1 
ATOM   2744 C CA  . GLU B 1 118 ? 35.79513  3.73766   28.07286  1.000 15.56160 ? 118 GLU B CA  1 
ATOM   2745 C C   . GLU B 1 118 ? 37.22383  3.97687   27.59688  1.000 17.11737 ? 118 GLU B C   1 
ATOM   2746 O O   . GLU B 1 118 ? 38.04912  4.48006   28.36789  1.000 18.66882 ? 118 GLU B O   1 
ATOM   2747 C CB  . GLU B 1 118 ? 35.76588  2.59440   29.08248  1.000 16.13549 ? 118 GLU B CB  1 
ATOM   2748 C CG  . GLU B 1 118 ? 34.41320  2.46511   29.76733  1.000 24.40291 ? 118 GLU B CG  1 
ATOM   2749 C CD  . GLU B 1 118 ? 34.08470  3.71892   30.56488  1.000 30.07505 ? 118 GLU B CD  1 
ATOM   2750 O OE1 . GLU B 1 118 ? 35.00822  4.24871   31.21502  1.000 34.09900 ? 118 GLU B OE1 1 
ATOM   2751 O OE2 . GLU B 1 118 ? 32.92681  4.19230   30.52374  1.000 25.85080 ? 118 GLU B OE2 1 
ATOM   2752 N N   . ASN B 1 119 ? 37.54637  3.62499   26.35598  1.000 17.41152 ? 119 ASN B N   1 
ATOM   2753 C CA  . ASN B 1 119 ? 38.89272  3.86364   25.85021  1.000 14.76381 ? 119 ASN B CA  1 
ATOM   2754 C C   . ASN B 1 119 ? 39.09162  5.25766   25.28938  1.000 18.49393 ? 119 ASN B C   1 
ATOM   2755 O O   . ASN B 1 119 ? 40.23166  5.62084   24.99731  1.000 20.14052 ? 119 ASN B O   1 
ATOM   2756 C CB  . ASN B 1 119 ? 39.23832  2.85350   24.76541  1.000 17.25369 ? 119 ASN B CB  1 
ATOM   2757 C CG  . ASN B 1 119 ? 39.37049  1.46151   25.30414  1.000 21.35414 ? 119 ASN B CG  1 
ATOM   2758 O OD1 . ASN B 1 119 ? 40.36848  1.12333   25.93070  1.000 19.77021 ? 119 ASN B OD1 1 
ATOM   2759 N ND2 . ASN B 1 119 ? 38.36009  0.63775   25.06603  1.000 19.10078 ? 119 ASN B ND2 1 
ATOM   2760 N N   . PHE B 1 120 ? 38.02544  6.02345   25.10863  1.000 21.21848 ? 120 PHE B N   1 
ATOM   2761 C CA  . PHE B 1 120 ? 38.13453  7.30633   24.42809  1.000 21.71217 ? 120 PHE B CA  1 
ATOM   2762 C C   . PHE B 1 120 ? 38.47950  8.40575   25.42811  1.000 20.42014 ? 120 PHE B C   1 
ATOM   2763 O O   . PHE B 1 120 ? 37.98382  8.39706   26.56094  1.000 18.97734 ? 120 PHE B O   1 
ATOM   2764 C CB  . PHE B 1 120 ? 36.82967  7.65715   23.71777  1.000 18.76661 ? 120 PHE B CB  1 
ATOM   2765 C CG  . PHE B 1 120 ? 36.33841  6.59041   22.75422  1.000 16.42577 ? 120 PHE B CG  1 
ATOM   2766 C CD1 . PHE B 1 120 ? 37.21000  5.95217   21.88446  1.000 20.37886 ? 120 PHE B CD1 1 
ATOM   2767 C CD2 . PHE B 1 120 ? 34.99098  6.23962   22.71658  1.000 17.82812 ? 120 PHE B CD2 1 
ATOM   2768 C CE1 . PHE B 1 120 ? 36.75188  4.97845   20.98718  1.000 17.49936 ? 120 PHE B CE1 1 
ATOM   2769 C CE2 . PHE B 1 120 ? 34.53139  5.26769   21.82762  1.000 14.17835 ? 120 PHE B CE2 1 
ATOM   2770 C CZ  . PHE B 1 120 ? 35.41897  4.63522   20.96728  1.000 19.15668 ? 120 PHE B CZ  1 
ATOM   2771 N N   . PRO B 1 121 ? 39.34646  9.32200   25.04423  1.000 19.30580 ? 121 PRO B N   1 
ATOM   2772 C CA  . PRO B 1 121 ? 39.69306  10.45320  25.93167  1.000 29.66655 ? 121 PRO B CA  1 
ATOM   2773 C C   . PRO B 1 121 ? 38.67006  11.57746  25.77663  1.000 27.10124 ? 121 PRO B C   1 
ATOM   2774 O O   . PRO B 1 121 ? 38.83576  12.53610  25.03487  1.000 32.89214 ? 121 PRO B O   1 
ATOM   2775 C CB  . PRO B 1 121 ? 41.09509  10.84380  25.45548  1.000 29.81686 ? 121 PRO B CB  1 
ATOM   2776 C CG  . PRO B 1 121 ? 41.15879  10.38655  24.01169  1.000 28.50855 ? 121 PRO B CG  1 
ATOM   2777 C CD  . PRO B 1 121 ? 40.26998  9.18746   23.89924  1.000 32.69268 ? 121 PRO B CD  1 
ATOM   2778 N N   . VAL B 1 122 ? 37.55838  11.43425  26.48982  1.000 31.94554 ? 122 VAL B N   1 
ATOM   2779 C CA  . VAL B 1 122 ? 36.49134  12.43504  26.41661  1.000 33.19611 ? 122 VAL B CA  1 
ATOM   2780 C C   . VAL B 1 122 ? 37.02668  13.76296  26.93412  1.000 37.71813 ? 122 VAL B C   1 
ATOM   2781 O O   . VAL B 1 122 ? 37.65231  13.79482  28.00994  1.000 31.82676 ? 122 VAL B O   1 
ATOM   2782 C CB  . VAL B 1 122 ? 35.26397  11.96918  27.22368  1.000 31.85131 ? 122 VAL B CB  1 
ATOM   2783 C CG1 . VAL B 1 122 ? 34.24294  13.07768  27.34039  1.000 32.10263 ? 122 VAL B CG1 1 
ATOM   2784 C CG2 . VAL B 1 122 ? 34.63431  10.75576  26.55560  1.000 30.44079 ? 122 VAL B CG2 1 
ATOM   2785 N N   . PRO B 1 123 ? 36.84241  14.87318  26.20739  1.000 40.36056 ? 123 PRO B N   1 
ATOM   2786 C CA  . PRO B 1 123 ? 37.46578  16.13655  26.64078  1.000 46.45905 ? 123 PRO B CA  1 
ATOM   2787 C C   . PRO B 1 123 ? 36.86434  16.70548  27.91282  1.000 35.91650 ? 123 PRO B C   1 
ATOM   2788 O O   . PRO B 1 123 ? 37.59600  17.25035  28.74617  1.000 43.41365 ? 123 PRO B O   1 
ATOM   2789 C CB  . PRO B 1 123 ? 37.24071  17.07374  25.44044  1.000 42.02635 ? 123 PRO B CB  1 
ATOM   2790 C CG  . PRO B 1 123 ? 36.78512  16.20650  24.31690  1.000 31.32068 ? 123 PRO B CG  1 
ATOM   2791 C CD  . PRO B 1 123 ? 36.10963  15.02736  24.94216  1.000 35.87333 ? 123 PRO B CD  1 
ATOM   2792 N N   . GLU B 1 124 ? 35.55323  16.60273  28.09134  1.000 39.40297 ? 124 GLU B N   1 
ATOM   2793 C CA  . GLU B 1 124 ? 34.88517  17.12750  29.27621  1.000 35.88168 ? 124 GLU B CA  1 
ATOM   2794 C C   . GLU B 1 124 ? 34.16862  15.99159  29.99323  1.000 38.07527 ? 124 GLU B C   1 
ATOM   2795 O O   . GLU B 1 124 ? 33.36585  15.27949  29.38332  1.000 32.83119 ? 124 GLU B O   1 
ATOM   2796 C CB  . GLU B 1 124 ? 33.89417  18.22823  28.89855  1.000 34.05595 ? 124 GLU B CB  1 
ATOM   2797 C CG  . GLU B 1 124 ? 33.78643  19.33111  29.94074  1.000 52.20106 ? 124 GLU B CG  1 
ATOM   2798 C CD  . GLU B 1 124 ? 35.07204  20.13657  30.06042  1.000 52.68355 ? 124 GLU B CD  1 
ATOM   2799 O OE1 . GLU B 1 124 ? 35.89563  20.10391  29.11308  1.000 49.74185 ? 124 GLU B OE1 1 
ATOM   2800 O OE2 . GLU B 1 124 ? 35.25237  20.81055  31.09864  1.000 65.03964 ? 124 GLU B OE2 1 
ATOM   2801 N N   . GLU B 1 125 ? 34.43798  15.83631  31.29205  1.000 37.43215 ? 125 GLU B N   1 
ATOM   2802 C CA  . GLU B 1 125 ? 33.75764  14.79570  32.05970  1.000 28.93224 ? 125 GLU B CA  1 
ATOM   2803 C C   . GLU B 1 125 ? 32.25215  14.98822  32.05291  1.000 27.72980 ? 125 GLU B C   1 
ATOM   2804 O O   . GLU B 1 125 ? 31.50075  14.03219  32.26508  1.000 28.03578 ? 125 GLU B O   1 
ATOM   2805 C CB  . GLU B 1 125 ? 34.27987  14.76484  33.49822  1.000 37.14221 ? 125 GLU B CB  1 
ATOM   2806 C CG  . GLU B 1 125 ? 35.13984  13.54958  33.81957  1.000 50.33224 ? 125 GLU B CG  1 
ATOM   2807 C CD  . GLU B 1 125 ? 34.40798  12.51234  34.66900  1.000 58.18883 ? 125 GLU B CD  1 
ATOM   2808 O OE1 . GLU B 1 125 ? 33.41028  12.87315  35.33697  1.000 51.64969 ? 125 GLU B OE1 1 
ATOM   2809 O OE2 . GLU B 1 125 ? 34.83780  11.33387  34.66993  1.000 55.57838 ? 125 GLU B OE2 1 
ATOM   2810 N N   . SER B 1 126 ? 31.78740  16.20812  31.81187  1.000 31.44720 ? 126 SER B N   1 
ATOM   2811 C CA  . SER B 1 126 ? 30.35289  16.43550  31.82954  1.000 28.65568 ? 126 SER B CA  1 
ATOM   2812 C C   . SER B 1 126 ? 29.67365  15.82288  30.61311  1.000 24.04434 ? 126 SER B C   1 
ATOM   2813 O O   . SER B 1 126 ? 28.46926  15.54068  30.65973  1.000 25.13876 ? 126 SER B O   1 
ATOM   2814 C CB  . SER B 1 126 ? 30.06988  17.92884  31.89904  1.000 28.48866 ? 126 SER B CB  1 
ATOM   2815 O OG  . SER B 1 126 ? 30.50434  18.56223  30.70876  1.000 34.87281 ? 126 SER B OG  1 
ATOM   2816 N N   . TRP B 1 127 ? 30.41966  15.61745  29.52535  1.000 24.15938 ? 127 TRP B N   1 
ATOM   2817 C CA  . TRP B 1 127 ? 29.88313  14.91243  28.36756  1.000 20.43830 ? 127 TRP B CA  1 
ATOM   2818 C C   . TRP B 1 127 ? 29.43249  13.50286  28.72216  1.000 19.74284 ? 127 TRP B C   1 
ATOM   2819 O O   . TRP B 1 127 ? 28.60760  12.92769  28.00491  1.000 19.72725 ? 127 TRP B O   1 
ATOM   2820 C CB  . TRP B 1 127 ? 30.93092  14.85560  27.25845  1.000 21.60978 ? 127 TRP B CB  1 
ATOM   2821 C CG  . TRP B 1 127 ? 31.19271  16.16726  26.60232  1.000 31.84985 ? 127 TRP B CG  1 
ATOM   2822 C CD1 . TRP B 1 127 ? 30.81990  17.39908  27.04847  1.000 27.18052 ? 127 TRP B CD1 1 
ATOM   2823 C CD2 . TRP B 1 127 ? 31.87601  16.37947  25.36147  1.000 37.34539 ? 127 TRP B CD2 1 
ATOM   2824 N NE1 . TRP B 1 127 ? 31.23584  18.36579  26.16808  1.000 30.85543 ? 127 TRP B NE1 1 
ATOM   2825 C CE2 . TRP B 1 127 ? 31.88435  17.76697  25.12259  1.000 29.33910 ? 127 TRP B CE2 1 
ATOM   2826 C CE3 . TRP B 1 127 ? 32.48153  15.53040  24.43171  1.000 31.76767 ? 127 TRP B CE3 1 
ATOM   2827 C CZ2 . TRP B 1 127 ? 32.46966  18.32458  23.99347  1.000 35.19274 ? 127 TRP B CZ2 1 
ATOM   2828 C CZ3 . TRP B 1 127 ? 33.06791  16.09083  23.30860  1.000 43.26064 ? 127 TRP B CZ3 1 
ATOM   2829 C CH2 . TRP B 1 127 ? 33.05758  17.47081  23.10064  1.000 35.58433 ? 127 TRP B CH2 1 
ATOM   2830 N N   . LEU B 1 128 ? 29.95970  12.93594  29.81073  1.000 21.35169 ? 128 LEU B N   1 
ATOM   2831 C CA  . LEU B 1 128 ? 29.52683  11.62344  30.27535  1.000 26.21070 ? 128 LEU B CA  1 
ATOM   2832 C C   . LEU B 1 128 ? 28.07171  11.62448  30.71175  1.000 24.22520 ? 128 LEU B C   1 
ATOM   2833 O O   . LEU B 1 128 ? 27.43553  10.55905  30.73441  1.000 19.44283 ? 128 LEU B O   1 
ATOM   2834 C CB  . LEU B 1 128 ? 30.43115  11.16269  31.42238  1.000 24.20588 ? 128 LEU B CB  1 
ATOM   2835 C CG  . LEU B 1 128 ? 31.90763  11.12704  31.04102  1.000 26.92085 ? 128 LEU B CG  1 
ATOM   2836 C CD1 . LEU B 1 128 ? 32.76810  10.56038  32.16455  1.000 26.03689 ? 128 LEU B CD1 1 
ATOM   2837 C CD2 . LEU B 1 128 ? 32.07275  10.32150  29.76707  1.000 24.39551 ? 128 LEU B CD2 1 
ATOM   2838 N N   . ASP B 1 129 ? 27.52458  12.80134  31.01924  1.000 21.75461 ? 129 ASP B N   1 
ATOM   2839 C CA  . ASP B 1 129 ? 26.13625  12.95812  31.41577  1.000 21.38444 ? 129 ASP B CA  1 
ATOM   2840 C C   . ASP B 1 129 ? 25.21896  13.35316  30.27781  1.000 18.30584 ? 129 ASP B C   1 
ATOM   2841 O O   . ASP B 1 129 ? 24.02989  13.56811  30.51670  1.000 21.40457 ? 129 ASP B O   1 
ATOM   2842 C CB  . ASP B 1 129 ? 26.03914  13.99937  32.53076  1.000 24.77799 ? 129 ASP B CB  1 
ATOM   2843 C CG  . ASP B 1 129 ? 26.65159  13.50328  33.79652  1.000 27.49541 ? 129 ASP B CG  1 
ATOM   2844 O OD1 . ASP B 1 129 ? 26.11388  12.51394  34.33366  1.000 34.77786 ? 129 ASP B OD1 1 
ATOM   2845 O OD2 . ASP B 1 129 ? 27.69230  14.05363  34.21867  1.000 36.42702 ? 129 ASP B OD2 1 
ATOM   2846 N N   . ASP B 1 130 ? 25.72587  13.44819  29.07140  1.000 16.47054 ? 130 ASP B N   1 
ATOM   2847 C CA  . ASP B 1 130 ? 24.94936  13.82825  27.90359  1.000 18.22185 ? 130 ASP B CA  1 
ATOM   2848 C C   . ASP B 1 130 ? 24.61086  12.61673  27.05654  1.000 20.34401 ? 130 ASP B C   1 
ATOM   2849 O O   . ASP B 1 130 ? 25.28556  11.58233  27.12520  1.000 17.11117 ? 130 ASP B O   1 
ATOM   2850 C CB  . ASP B 1 130 ? 25.73669  14.81338  27.03394  1.000 28.28435 ? 130 ASP B CB  1 
ATOM   2851 C CG  . ASP B 1 130 ? 25.93061  16.16195  27.68889  1.000 24.72240 ? 130 ASP B CG  1 
ATOM   2852 O OD1 . ASP B 1 130 ? 25.11701  16.53396  28.56294  1.000 30.34576 ? 130 ASP B OD1 1 
ATOM   2853 O OD2 . ASP B 1 130 ? 26.91106  16.84009  27.31440  1.000 26.49551 ? 130 ASP B OD2 1 
ATOM   2854 N N   . PRO B 1 131 ? 23.58312  12.72895  26.21850  1.000 21.07993 ? 131 PRO B N   1 
ATOM   2855 C CA  . PRO B 1 131 ? 23.34615  11.70186  25.20222  1.000 14.31823 ? 131 PRO B CA  1 
ATOM   2856 C C   . PRO B 1 131 ? 24.45600  11.67529  24.16115  1.000 17.97430 ? 131 PRO B C   1 
ATOM   2857 O O   . PRO B 1 131 ? 25.08183  12.69273  23.84586  1.000 22.80759 ? 131 PRO B O   1 
ATOM   2858 C CB  . PRO B 1 131 ? 22.01700  12.12978  24.57208  1.000 24.67418 ? 131 PRO B CB  1 
ATOM   2859 C CG  . PRO B 1 131 ? 21.37134  13.02594  25.59268  1.000 20.95452 ? 131 PRO B CG  1 
ATOM   2860 C CD  . PRO B 1 131 ? 22.49812  13.73063  26.25871  1.000 18.22565 ? 131 PRO B CD  1 
ATOM   2861 N N   . TRP B 1 132 ? 24.71629  10.47839  23.64918  1.000 13.24301 ? 132 TRP B N   1 
ATOM   2862 C CA  . TRP B 1 132 ? 25.60561  10.26586  22.51748  1.000 13.46087 ? 132 TRP B CA  1 
ATOM   2863 C C   . TRP B 1 132 ? 24.82940  9.47703   21.48108  1.000 13.02908 ? 132 TRP B C   1 
ATOM   2864 O O   . TRP B 1 132 ? 23.98976  8.64475   21.82831  1.000 12.15069 ? 132 TRP B O   1 
ATOM   2865 C CB  . TRP B 1 132 ? 26.87119  9.49916   22.89622  1.000 13.56501 ? 132 TRP B CB  1 
ATOM   2866 C CG  . TRP B 1 132 ? 27.78365  10.26032  23.76612  1.000 12.26833 ? 132 TRP B CG  1 
ATOM   2867 C CD1 . TRP B 1 132 ? 27.50213  10.75825  24.99947  1.000 16.77029 ? 132 TRP B CD1 1 
ATOM   2868 C CD2 . TRP B 1 132 ? 29.13452  10.62817  23.48270  1.000 17.63620 ? 132 TRP B CD2 1 
ATOM   2869 N NE1 . TRP B 1 132 ? 28.58753  11.40893  25.50207  1.000 10.80486 ? 132 TRP B NE1 1 
ATOM   2870 C CE2 . TRP B 1 132 ? 29.60668  11.34938  24.59181  1.000 12.42591 ? 132 TRP B CE2 1 
ATOM   2871 C CE3 . TRP B 1 132 ? 29.99140  10.41593  22.39897  1.000 16.34452 ? 132 TRP B CE3 1 
ATOM   2872 C CZ2 . TRP B 1 132 ? 30.89733  11.86513  24.65595  1.000 21.63132 ? 132 TRP B CZ2 1 
ATOM   2873 C CZ3 . TRP B 1 132 ? 31.26852  10.92149  22.45961  1.000 15.17233 ? 132 TRP B CZ3 1 
ATOM   2874 C CH2 . TRP B 1 132 ? 31.71513  11.64802  23.58079  1.000 24.10389 ? 132 TRP B CH2 1 
ATOM   2875 N N   . ASP B 1 133 ? 25.06908  9.77036   20.20682  1.000 15.02905 ? 133 ASP B N   1 
ATOM   2876 C CA  . ASP B 1 133 ? 24.51062  8.95398   19.14395  1.000 14.90090 ? 133 ASP B CA  1 
ATOM   2877 C C   . ASP B 1 133 ? 25.56873  7.95481   18.72779  1.000 11.96880 ? 133 ASP B C   1 
ATOM   2878 O O   . ASP B 1 133 ? 26.70150  8.33286   18.43281  1.000 15.83297 ? 133 ASP B O   1 
ATOM   2879 C CB  . ASP B 1 133 ? 24.05099  9.77229   17.94026  1.000 17.88433 ? 133 ASP B CB  1 
ATOM   2880 C CG  . ASP B 1 133 ? 23.41484  8.89230   16.85649  1.000 27.70999 ? 133 ASP B CG  1 
ATOM   2881 O OD1 . ASP B 1 133 ? 22.36670  8.25937   17.11240  1.000 26.40884 ? 133 ASP B OD1 1 
ATOM   2882 O OD2 . ASP B 1 133 ? 23.98040  8.79388   15.75199  1.000 39.80190 ? 133 ASP B OD2 1 
ATOM   2883 N N   . VAL B 1 134 ? 25.20938  6.67811   18.74672  1.000 16.27145 ? 134 VAL B N   1 
ATOM   2884 C CA  . VAL B 1 134 ? 26.13422  5.60421   18.43077  1.000 14.62056 ? 134 VAL B CA  1 
ATOM   2885 C C   . VAL B 1 134 ? 25.57488  4.86555   17.23017  1.000 17.35810 ? 134 VAL B C   1 
ATOM   2886 O O   . VAL B 1 134 ? 24.46757  4.32187   17.29931  1.000 13.45424 ? 134 VAL B O   1 
ATOM   2887 C CB  . VAL B 1 134 ? 26.34876  4.65106   19.61563  1.000 13.56916 ? 134 VAL B CB  1 
ATOM   2888 C CG1 . VAL B 1 134 ? 27.43616  3.63854   19.28244  1.000 12.18524 ? 134 VAL B CG1 1 
ATOM   2889 C CG2 . VAL B 1 134 ? 26.73358  5.42606   20.87152  1.000 12.05015 ? 134 VAL B CG2 1 
ATOM   2890 N N   . GLN B 1 135 ? 26.32349  4.88493   16.12487  1.000 11.49824 ? 135 GLN B N   1 
ATOM   2891 C CA  . GLN B 1 135 ? 25.99845  4.09440   14.94774  1.000 19.70281 ? 135 GLN B CA  1 
ATOM   2892 C C   . GLN B 1 135 ? 26.66873  2.74171   15.06989  1.000 17.28012 ? 135 GLN B C   1 
ATOM   2893 O O   . GLN B 1 135 ? 27.83551  2.65358   15.44609  1.000 13.80522 ? 135 GLN B O   1 
ATOM   2894 C CB  . GLN B 1 135 ? 26.50167  4.75263   13.66335  1.000 19.23200 ? 135 GLN B CB  1 
ATOM   2895 C CG  . GLN B 1 135 ? 26.25809  6.20285   13.56191  1.000 33.95786 ? 135 GLN B CG  1 
ATOM   2896 C CD  . GLN B 1 135 ? 27.07337  6.78486   12.45942  1.000 36.79490 ? 135 GLN B CD  1 
ATOM   2897 O OE1 . GLN B 1 135 ? 27.31883  6.12223   11.44317  1.000 39.32978 ? 135 GLN B OE1 1 
ATOM   2898 N NE2 . GLN B 1 135 ? 27.52773  8.01016   12.64750  1.000 23.17499 ? 135 GLN B NE2 1 
ATOM   2899 N N   . CYS B 1 136 ? 25.94157  1.69345   14.72409  1.000 9.81756  ? 136 CYS B N   1 
ATOM   2900 C CA  . CYS B 1 136 ? 26.46011  0.33877   14.82538  1.000 9.63685  ? 136 CYS B CA  1 
ATOM   2901 C C   . CYS B 1 136 ? 26.25596  -0.34532  13.47783  1.000 12.95027 ? 136 CYS B C   1 
ATOM   2902 O O   . CYS B 1 136 ? 25.11487  -0.54657  13.05689  1.000 15.30527 ? 136 CYS B O   1 
ATOM   2903 C CB  . CYS B 1 136 ? 25.74782  -0.39538  15.95110  1.000 18.92684 ? 136 CYS B CB  1 
ATOM   2904 S SG  . CYS B 1 136 ? 26.18745  -2.09512  16.11687  1.000 21.29534 ? 136 CYS B SG  1 
ATOM   2905 N N   . HIS B 1 137 ? 27.35443  -0.69094  12.80336  1.000 13.64430 ? 137 HIS B N   1 
ATOM   2906 C CA  . HIS B 1 137 ? 27.34619  -1.22128  11.44022  1.000 17.02307 ? 137 HIS B CA  1 
ATOM   2907 C C   . HIS B 1 137 ? 27.90910  -2.63203  11.40450  1.000 14.59515 ? 137 HIS B C   1 
ATOM   2908 O O   . HIS B 1 137 ? 29.02402  -2.85881  11.87474  1.000 12.85708 ? 137 HIS B O   1 
ATOM   2909 C CB  . HIS B 1 137 ? 28.20447  -0.35970  10.51267  1.000 17.17363 ? 137 HIS B CB  1 
ATOM   2910 C CG  . HIS B 1 137 ? 27.77860  1.06850   10.44487  1.000 24.86353 ? 137 HIS B CG  1 
ATOM   2911 N ND1 . HIS B 1 137 ? 26.88983  1.53027   9.49763   1.000 28.37929 ? 137 HIS B ND1 1 
ATOM   2912 C CD2 . HIS B 1 137 ? 28.12674  2.14276   11.19376  1.000 19.96016 ? 137 HIS B CD2 1 
ATOM   2913 C CE1 . HIS B 1 137 ? 26.71182  2.82813   9.66258   1.000 31.25801 ? 137 HIS B CE1 1 
ATOM   2914 N NE2 . HIS B 1 137 ? 27.44808  3.22351   10.68736  1.000 29.89929 ? 137 HIS B NE2 1 
ATOM   2915 N N   . GLN B 1 138 ? 27.16446  -3.56572  10.80716  1.000 13.28073 ? 138 GLN B N   1 
ATOM   2916 C CA  . GLN B 1 138 ? 27.68168  -4.89002  10.49143  1.000 16.95986 ? 138 GLN B CA  1 
ATOM   2917 C C   . GLN B 1 138 ? 28.07558  -4.88646  9.01997   1.000 19.79223 ? 138 GLN B C   1 
ATOM   2918 O O   . GLN B 1 138 ? 27.20674  -4.79798  8.15483   1.000 23.00742 ? 138 GLN B O   1 
ATOM   2919 C CB  . GLN B 1 138 ? 26.64203  -5.96994  10.76777  1.000 17.24606 ? 138 GLN B CB  1 
ATOM   2920 C CG  . GLN B 1 138 ? 26.33090  -6.18486  12.22812  1.000 18.01390 ? 138 GLN B CG  1 
ATOM   2921 C CD  . GLN B 1 138 ? 25.26082  -7.21766  12.41161  1.000 23.38085 ? 138 GLN B CD  1 
ATOM   2922 O OE1 . GLN B 1 138 ? 24.17893  -7.10573  11.83297  1.000 20.99287 ? 138 GLN B OE1 1 
ATOM   2923 N NE2 . GLN B 1 138 ? 25.54605  -8.23920  13.22099  1.000 18.76727 ? 138 GLN B NE2 1 
ATOM   2924 N N   . PHE B 1 139 ? 29.37621  -4.96101  8.73189   1.000 21.66355 ? 139 PHE B N   1 
ATOM   2925 C CA  . PHE B 1 139 ? 29.87660  -4.90878  7.36028   1.000 23.35160 ? 139 PHE B CA  1 
ATOM   2926 C C   . PHE B 1 139 ? 30.48863  -6.24599  6.99017   1.000 27.77471 ? 139 PHE B C   1 
ATOM   2927 O O   . PHE B 1 139 ? 31.34260  -6.75425  7.72127   1.000 18.46825 ? 139 PHE B O   1 
ATOM   2928 C CB  . PHE B 1 139 ? 30.93536  -3.81861  7.18665   1.000 22.08412 ? 139 PHE B CB  1 
ATOM   2929 C CG  . PHE B 1 139 ? 30.37707  -2.46412  6.92569   1.000 28.68200 ? 139 PHE B CG  1 
ATOM   2930 C CD1 . PHE B 1 139 ? 29.41525  -2.26589  5.94939   1.000 50.29373 ? 139 PHE B CD1 1 
ATOM   2931 C CD2 . PHE B 1 139 ? 30.81542  -1.37515  7.65486   1.000 41.54392 ? 139 PHE B CD2 1 
ATOM   2932 C CE1 . PHE B 1 139 ? 28.90200  -0.99791  5.71250   1.000 48.55115 ? 139 PHE B CE1 1 
ATOM   2933 C CE2 . PHE B 1 139 ? 30.30134  -0.10289  7.42215   1.000 37.60730 ? 139 PHE B CE2 1 
ATOM   2934 C CZ  . PHE B 1 139 ? 29.34958  0.08034   6.45234   1.000 39.19701 ? 139 PHE B CZ  1 
ATOM   2935 N N   . ARG B 1 140 ? 30.09267  -6.78972  5.83635   1.000 24.01917 ? 140 ARG B N   1 
ATOM   2936 C CA  . ARG B 1 140 ? 30.78642  -7.92835  5.23787   1.000 26.35461 ? 140 ARG B CA  1 
ATOM   2937 C C   . ARG B 1 140 ? 31.23337  -7.56040  3.83365   1.000 26.50191 ? 140 ARG B C   1 
ATOM   2938 O O   . ARG B 1 140 ? 30.40854  -7.19199  2.98830   1.000 29.25834 ? 140 ARG B O   1 
ATOM   2939 C CB  . ARG B 1 140 ? 29.91948  -9.18732  5.18229   1.000 25.93507 ? 140 ARG B CB  1 
ATOM   2940 C CG  . ARG B 1 140 ? 30.41948  -10.14928 4.11176   1.000 24.31480 ? 140 ARG B CG  1 
ATOM   2941 C CD  . ARG B 1 140 ? 29.78307  -11.50371 4.22218   1.000 29.02372 ? 140 ARG B CD  1 
ATOM   2942 N NE  . ARG B 1 140 ? 30.36453  -12.24616 5.33271   1.000 32.41608 ? 140 ARG B NE  1 
ATOM   2943 C CZ  . ARG B 1 140 ? 30.00437  -13.46875 5.67784   1.000 21.05754 ? 140 ARG B CZ  1 
ATOM   2944 N NH1 . ARG B 1 140 ? 29.06754  -14.12411 5.01337   1.000 38.09166 ? 140 ARG B NH1 1 
ATOM   2945 N NH2 . ARG B 1 140 ? 30.59673  -14.04598 6.71328   1.000 24.96165 ? 140 ARG B NH2 1 
ATOM   2946 N N   . ILE B 1 141 ? 32.53110  -7.67064  3.59261   1.000 20.07565 ? 141 ILE B N   1 
ATOM   2947 C CA  . ILE B 1 141 ? 33.14391  -7.39543  2.29776   1.000 25.78196 ? 141 ILE B CA  1 
ATOM   2948 C C   . ILE B 1 141 ? 33.45483  -8.73491  1.64328   1.000 30.51911 ? 141 ILE B C   1 
ATOM   2949 O O   . ILE B 1 141 ? 34.13722  -9.57657  2.24217   1.000 29.57933 ? 141 ILE B O   1 
ATOM   2950 C CB  . ILE B 1 141 ? 34.41506  -6.54446  2.45914   1.000 32.83673 ? 141 ILE B CB  1 
ATOM   2951 C CG1 . ILE B 1 141 ? 34.08372  -5.21479  3.14670   1.000 37.08529 ? 141 ILE B CG1 1 
ATOM   2952 C CG2 . ILE B 1 141 ? 35.07269  -6.27819  1.12282   1.000 35.42646 ? 141 ILE B CG2 1 
ATOM   2953 C CD1 . ILE B 1 141 ? 35.28465  -4.27911  3.26844   1.000 50.29603 ? 141 ILE B CD1 1 
ATOM   2954 N N   . ILE B 1 142 ? 32.93682  -8.95487  0.43239   1.000 31.79257 ? 142 ILE B N   1 
ATOM   2955 C CA  . ILE B 1 142 ? 33.21268  -10.16488 -0.33727  1.000 29.61073 ? 142 ILE B CA  1 
ATOM   2956 C C   . ILE B 1 142 ? 33.97721  -9.77674  -1.59385  1.000 36.33412 ? 142 ILE B C   1 
ATOM   2957 O O   . ILE B 1 142 ? 33.58673  -8.84199  -2.30363  1.000 40.86045 ? 142 ILE B O   1 
ATOM   2958 C CB  . ILE B 1 142 ? 31.92659  -10.92371 -0.69608  1.000 34.75208 ? 142 ILE B CB  1 
ATOM   2959 C CG1 . ILE B 1 142 ? 31.11748  -11.25034 0.55326   1.000 26.95278 ? 142 ILE B CG1 1 
ATOM   2960 C CG2 . ILE B 1 142 ? 32.26233  -12.20670 -1.44418  1.000 39.53710 ? 142 ILE B CG2 1 
ATOM   2961 C CD1 . ILE B 1 142 ? 29.81800  -10.49545 0.61538   1.000 36.18431 ? 142 ILE B CD1 1 
ATOM   2962 N N   . SER B 1 143 ? 35.05890  -10.49450 -1.87323  1.000 25.07853 ? 143 SER B N   1 
ATOM   2963 C CA  . SER B 1 143 ? 35.93502  -10.17291 -2.98481  1.000 27.38205 ? 143 SER B CA  1 
ATOM   2964 C C   . SER B 1 143 ? 36.22332  -11.43183 -3.79027  1.000 36.25202 ? 143 SER B C   1 
ATOM   2965 O O   . SER B 1 143 ? 36.61565  -12.46034 -3.22961  1.000 33.96294 ? 143 SER B O   1 
ATOM   2966 C CB  . SER B 1 143 ? 37.23017  -9.54454  -2.47479  1.000 28.14908 ? 143 SER B CB  1 
ATOM   2967 O OG  . SER B 1 143 ? 38.04023  -9.08773  -3.53298  1.000 35.31539 ? 143 SER B OG  1 
ATOM   2968 N N   . THR B 1 144 ? 36.03478  -11.34724 -5.10130  1.000 39.78451 ? 144 THR B N   1 
ATOM   2969 C CA  . THR B 1 144 ? 36.27655  -12.45133 -6.01187  1.000 38.16242 ? 144 THR B CA  1 
ATOM   2970 C C   . THR B 1 144 ? 37.30482  -12.03103 -7.05897  1.000 48.82796 ? 144 THR B C   1 
ATOM   2971 O O   . THR B 1 144 ? 37.55212  -10.83226 -7.24028  1.000 47.19415 ? 144 THR B O   1 
ATOM   2972 C CB  . THR B 1 144 ? 34.96673  -12.90251 -6.68278  1.000 41.97837 ? 144 THR B CB  1 
ATOM   2973 O OG1 . THR B 1 144 ? 34.40760  -11.83241 -7.45231  1.000 43.71956 ? 144 THR B OG1 1 
ATOM   2974 C CG2 . THR B 1 144 ? 33.95839  -13.34660 -5.62930  1.000 41.66593 ? 144 THR B CG2 1 
ATOM   2975 N N   . PRO B 1 145 ? 37.94969  -13.02142 -7.76609  1.000 49.92178 ? 145 PRO B N   1 
ATOM   2976 C CA  . PRO B 1 145 ? 39.04658  -12.73619 -8.71505  1.000 54.52862 ? 145 PRO B CA  1 
ATOM   2977 C C   . PRO B 1 145 ? 39.15176  -11.33579 -9.30457  1.000 49.49279 ? 145 PRO B C   1 
ATOM   2978 O O   . PRO B 1 145 ? 38.21352  -10.82354 -9.91860  1.000 51.02502 ? 145 PRO B O   1 
ATOM   2979 C CB  . PRO B 1 145 ? 38.78408  -13.76438 -9.82311  1.000 51.81594 ? 145 PRO B CB  1 
ATOM   2980 C CG  . PRO B 1 145 ? 38.09899  -14.95117 -9.08913  1.000 47.74625 ? 145 PRO B CG  1 
ATOM   2981 C CD  . PRO B 1 145 ? 37.72144  -14.47468 -7.68882  1.000 39.71234 ? 145 PRO B CD  1 
ATOM   2982 N N   . ASP B 1 146 ? 40.32800  -10.73727 -9.14122  1.000 55.46544 ? 146 ASP B N   1 
ATOM   2983 C CA  . ASP B 1 146 ? 40.55717  -9.33497  -9.45431  1.000 59.38841 ? 146 ASP B CA  1 
ATOM   2984 C C   . ASP B 1 146 ? 40.85676  -9.12930  -10.93546 1.000 63.69928 ? 146 ASP B C   1 
ATOM   2985 O O   . ASP B 1 146 ? 41.65556  -9.85656  -11.53022 1.000 69.17694 ? 146 ASP B O   1 
ATOM   2986 C CB  . ASP B 1 146 ? 41.72205  -8.80838  -8.60521  1.000 53.56330 ? 146 ASP B CB  1 
ATOM   2987 C CG  . ASP B 1 146 ? 41.58024  -7.33735  -8.25051  1.000 66.08637 ? 146 ASP B CG  1 
ATOM   2988 O OD1 . ASP B 1 146 ? 40.95518  -7.04146  -7.21062  1.000 55.49743 ? 146 ASP B OD1 1 
ATOM   2989 O OD2 . ASP B 1 146 ? 42.09890  -6.48553  -9.00540  1.000 69.45766 ? 146 ASP B OD2 1 
ATOM   2990 N N   . GLU B 1 147 ? 40.21510  -8.11965  -11.51993 1.000 72.62630 ? 147 GLU B N   1 
ATOM   2991 C CA  . GLU B 1 147 ? 40.59790  -7.58695  -12.82400 1.000 67.89495 ? 147 GLU B CA  1 
ATOM   2992 C C   . GLU B 1 147 ? 40.68450  -6.05699  -12.76075 1.000 69.60780 ? 147 GLU B C   1 
ATOM   2993 O O   . GLU B 1 147 ? 41.26422  -5.41434  -13.63610 1.000 72.37337 ? 147 GLU B O   1 
ATOM   2994 C CB  . GLU B 1 147 ? 39.60962  -8.01697  -13.91200 1.000 68.78963 ? 147 GLU B CB  1 
ATOM   2995 C CG  . GLU B 1 147 ? 39.68614  -9.49910  -14.26609 1.000 69.28057 ? 147 GLU B CG  1 
ATOM   2996 C CD  . GLU B 1 147 ? 41.08851  -9.94965  -14.68499 1.000 74.76694 ? 147 GLU B CD  1 
ATOM   2997 O OE1 . GLU B 1 147 ? 41.73617  -9.24916  -15.49683 1.000 65.39157 ? 147 GLU B OE1 1 
ATOM   2998 O OE2 . GLU B 1 147 ? 41.53522  -11.01284 -14.19753 1.000 78.54029 ? 147 GLU B OE2 1 
ATOM   2999 N N   . PRO B 1 151 ? 40.43722  -1.46163  -9.46242  1.000 69.13523 ? 151 PRO B N   1 
ATOM   3000 C CA  . PRO B 1 151 ? 40.17620  -1.72460  -8.04109  1.000 66.67367 ? 151 PRO B CA  1 
ATOM   3001 C C   . PRO B 1 151 ? 40.89530  -0.72797  -7.12775  1.000 61.08939 ? 151 PRO B C   1 
ATOM   3002 O O   . PRO B 1 151 ? 41.44085  -1.12604  -6.09272  1.000 57.62009 ? 151 PRO B O   1 
ATOM   3003 C CB  . PRO B 1 151 ? 40.73419  -3.13260  -7.85451  1.000 59.50557 ? 151 PRO B CB  1 
ATOM   3004 C CG  . PRO B 1 151 ? 41.92006  -3.16099  -8.79840  1.000 65.41938 ? 151 PRO B CG  1 
ATOM   3005 C CD  . PRO B 1 151 ? 41.57316  -2.25738  -9.96865  1.000 59.33558 ? 151 PRO B CD  1 
ATOM   3006 N N   . THR B 1 152 ? 40.87830  0.54635   -7.51487  1.000 47.47113 ? 152 THR B N   1 
ATOM   3007 C CA  . THR B 1 152 ? 41.75676  1.53782   -6.90589  1.000 43.55153 ? 152 THR B CA  1 
ATOM   3008 C C   . THR B 1 152 ? 41.42600  1.71701   -5.42753  1.000 39.15992 ? 152 THR B C   1 
ATOM   3009 O O   . THR B 1 152 ? 40.26228  1.95221   -5.08067  1.000 36.37625 ? 152 THR B O   1 
ATOM   3010 C CB  . THR B 1 152 ? 41.62847  2.86994   -7.64355  1.000 47.72735 ? 152 THR B CB  1 
ATOM   3011 O OG1 . THR B 1 152 ? 41.81825  2.65196   -9.04681  1.000 55.05508 ? 152 THR B OG1 1 
ATOM   3012 C CG2 . THR B 1 152 ? 42.66818  3.86244   -7.15499  1.000 34.58182 ? 152 THR B CG2 1 
ATOM   3013 N N   . PRO B 1 153 ? 42.40118  1.60526   -4.53152  1.000 39.94209 ? 153 PRO B N   1 
ATOM   3014 C CA  . PRO B 1 153 ? 42.11519  1.78230   -3.10399  1.000 41.44167 ? 153 PRO B CA  1 
ATOM   3015 C C   . PRO B 1 153 ? 41.61330  3.18776   -2.79811  1.000 41.91991 ? 153 PRO B C   1 
ATOM   3016 O O   . PRO B 1 153 ? 41.83540  4.14205   -3.54964  1.000 47.77054 ? 153 PRO B O   1 
ATOM   3017 C CB  . PRO B 1 153 ? 43.46453  1.50892   -2.43052  1.000 38.27145 ? 153 PRO B CB  1 
ATOM   3018 C CG  . PRO B 1 153 ? 44.21910  0.66451   -3.43131  1.000 44.87522 ? 153 PRO B CG  1 
ATOM   3019 C CD  . PRO B 1 153 ? 43.78602  1.16533   -4.77672  1.000 37.85023 ? 153 PRO B CD  1 
ATOM   3020 N N   . GLU B 1 154 ? 40.90824  3.29621   -1.67542  1.000 43.86501 ? 154 GLU B N   1 
ATOM   3021 C CA  . GLU B 1 154 ? 40.27635  4.54405   -1.27335  1.000 40.63845 ? 154 GLU B CA  1 
ATOM   3022 C C   . GLU B 1 154 ? 41.28048  5.48974   -0.62591  1.000 41.43958 ? 154 GLU B C   1 
ATOM   3023 O O   . GLU B 1 154 ? 42.22254  5.06590   0.05139   1.000 41.97160 ? 154 GLU B O   1 
ATOM   3024 C CB  . GLU B 1 154 ? 39.14674  4.26382   -0.29206  1.000 46.42103 ? 154 GLU B CB  1 
ATOM   3025 C CG  . GLU B 1 154 ? 39.61948  3.54250   0.96385   1.000 35.64965 ? 154 GLU B CG  1 
ATOM   3026 C CD  . GLU B 1 154 ? 38.53558  3.43262   2.01653   1.000 34.21782 ? 154 GLU B CD  1 
ATOM   3027 O OE1 . GLU B 1 154 ? 37.43679  3.98450   1.79645   1.000 53.32758 ? 154 GLU B OE1 1 
ATOM   3028 O OE2 . GLU B 1 154 ? 38.77891  2.79471   3.06195   1.000 32.65043 ? 154 GLU B OE2 1 
ATOM   3029 N N   . GLY B 1 155 ? 41.07304  6.78067   -0.83874  1.000 25.16885 ? 155 GLY B N   1 
ATOM   3030 C CA  . GLY B 1 155 ? 41.86464  7.78260   -0.16471  1.000 31.55480 ? 155 GLY B CA  1 
ATOM   3031 C C   . GLY B 1 155 ? 41.41268  7.98722   1.26647   1.000 27.10758 ? 155 GLY B C   1 
ATOM   3032 O O   . GLY B 1 155 ? 40.35911  7.50076   1.70627   1.000 28.81429 ? 155 GLY B O   1 
ATOM   3033 N N   . PRO B 1 156 ? 42.22224  8.72281   2.02759   1.000 31.76711 ? 156 PRO B N   1 
ATOM   3034 C CA  . PRO B 1 156 ? 41.90013  8.94611   3.44413   1.000 26.77697 ? 156 PRO B CA  1 
ATOM   3035 C C   . PRO B 1 156 ? 40.62760  9.76141   3.61612   1.000 31.84697 ? 156 PRO B C   1 
ATOM   3036 O O   . PRO B 1 156 ? 40.25524  10.56846  2.76032   1.000 32.44214 ? 156 PRO B O   1 
ATOM   3037 C CB  . PRO B 1 156 ? 43.12557  9.69619   3.97762   1.000 31.22880 ? 156 PRO B CB  1 
ATOM   3038 C CG  . PRO B 1 156 ? 43.79183  10.27579  2.75564   1.000 39.20786 ? 156 PRO B CG  1 
ATOM   3039 C CD  . PRO B 1 156 ? 43.52558  9.29758   1.65041   1.000 36.24344 ? 156 PRO B CD  1 
ATOM   3040 N N   . HIS B 1 157 ? 39.96223  9.54531   4.74963   1.000 28.05138 ? 157 HIS B N   1 
ATOM   3041 C CA  . HIS B 1 157 ? 38.64363  10.11941  4.97547   1.000 37.23949 ? 157 HIS B CA  1 
ATOM   3042 C C   . HIS B 1 157 ? 38.26889  9.96368   6.44382   1.000 32.82292 ? 157 HIS B C   1 
ATOM   3043 O O   . HIS B 1 157 ? 38.82403  9.12080   7.16086   1.000 26.58076 ? 157 HIS B O   1 
ATOM   3044 C CB  . HIS B 1 157 ? 37.59505  9.44044   4.09389   1.000 30.73346 ? 157 HIS B CB  1 
ATOM   3045 C CG  . HIS B 1 157 ? 37.35345  8.01566   4.46530   1.000 34.79601 ? 157 HIS B CG  1 
ATOM   3046 N ND1 . HIS B 1 157 ? 36.32625  7.63076   5.29928   1.000 39.73647 ? 157 HIS B ND1 1 
ATOM   3047 C CD2 . HIS B 1 157 ? 38.03237  6.88580   4.15742   1.000 35.80626 ? 157 HIS B CD2 1 
ATOM   3048 C CE1 . HIS B 1 157 ? 36.36925  6.32231   5.47294   1.000 33.63964 ? 157 HIS B CE1 1 
ATOM   3049 N NE2 . HIS B 1 157 ? 37.39599  5.84663   4.79154   1.000 39.07651 ? 157 HIS B NE2 1 
ATOM   3050 N N   . ARG B 1 158 ? 37.31887  10.79759  6.87044   1.000 29.12908 ? 158 ARG B N   1 
ATOM   3051 C CA  . ARG B 1 158 ? 36.66094  10.76304  8.17262   1.000 34.11712 ? 158 ARG B CA  1 
ATOM   3052 C C   . ARG B 1 158 ? 35.39534  9.92457   8.12063   1.000 28.71353 ? 158 ARG B C   1 
ATOM   3053 O O   . ARG B 1 158 ? 34.90823  9.54748   7.05261   1.000 38.87782 ? 158 ARG B O   1 
ATOM   3054 C CB  . ARG B 1 158 ? 36.22112  12.16148  8.62306   1.000 40.49735 ? 158 ARG B CB  1 
ATOM   3055 C CG  . ARG B 1 158 ? 37.23847  13.07645  9.20876   1.000 43.14847 ? 158 ARG B CG  1 
ATOM   3056 C CD  . ARG B 1 158 ? 36.49905  14.25757  9.83534   1.000 38.53315 ? 158 ARG B CD  1 
ATOM   3057 N NE  . ARG B 1 158 ? 35.83744  13.86765  11.07433  1.000 28.46043 ? 158 ARG B NE  1 
ATOM   3058 C CZ  . ARG B 1 158 ? 35.53987  14.70055  12.06325  1.000 39.31647 ? 158 ARG B CZ  1 
ATOM   3059 N NH1 . ARG B 1 158 ? 35.73828  16.00349  11.95259  1.000 31.33716 ? 158 ARG B NH1 1 
ATOM   3060 N NH2 . ARG B 1 158 ? 35.04059  14.21108  13.19841  1.000 30.04200 ? 158 ARG B NH2 1 
ATOM   3061 N N   . ASP B 1 159 ? 34.81135  9.70852   9.30094   1.000 29.83100 ? 159 ASP B N   1 
ATOM   3062 C CA  . ASP B 1 159 ? 33.45748  9.18380   9.41412   1.000 22.66337 ? 159 ASP B CA  1 
ATOM   3063 C C   . ASP B 1 159 ? 32.47995  10.19370  9.99717   1.000 28.09877 ? 159 ASP B C   1 
ATOM   3064 O O   . ASP B 1 159 ? 31.29249  9.87903   10.13012  1.000 32.27054 ? 159 ASP B O   1 
ATOM   3065 C CB  . ASP B 1 159 ? 33.46465  7.90656   10.25423  1.000 24.80547 ? 159 ASP B CB  1 
ATOM   3066 C CG  . ASP B 1 159 ? 34.16544  6.76577   9.54416   1.000 34.86713 ? 159 ASP B CG  1 
ATOM   3067 O OD1 . ASP B 1 159 ? 33.72504  6.40137   8.43161   1.000 34.23859 ? 159 ASP B OD1 1 
ATOM   3068 O OD2 . ASP B 1 159 ? 35.17824  6.26438   10.07091  1.000 40.01623 ? 159 ASP B OD2 1 
ATOM   3069 N N   . GLU B 1 160 ? 32.94524  11.39626  10.34260  1.000 26.66469 ? 160 GLU B N   1 
ATOM   3070 C CA  . GLU B 1 160 ? 32.09568  12.45677  10.89103  1.000 31.42839 ? 160 GLU B CA  1 
ATOM   3071 C C   . GLU B 1 160 ? 31.44182  12.02712  12.20699  1.000 27.45016 ? 160 GLU B C   1 
ATOM   3072 O O   . GLU B 1 160 ? 30.22933  12.12605  12.39010  1.000 26.42798 ? 160 GLU B O   1 
ATOM   3073 C CB  . GLU B 1 160 ? 31.04589  12.90863  9.87017   1.000 28.06682 ? 160 GLU B CB  1 
ATOM   3074 C CG  . GLU B 1 160 ? 31.62544  13.34124  8.52623   1.000 38.31824 ? 160 GLU B CG  1 
ATOM   3075 C CD  . GLU B 1 160 ? 32.60821  14.50278  8.64475   1.000 47.61038 ? 160 GLU B CD  1 
ATOM   3076 O OE1 . GLU B 1 160 ? 32.52321  15.26090  9.63750   1.000 46.13669 ? 160 GLU B OE1 1 
ATOM   3077 O OE2 . GLU B 1 160 ? 33.46819  14.65883  7.74463   1.000 47.12520 ? 160 GLU B OE2 1 
ATOM   3078 N N   . VAL B 1 161 ? 32.27080  11.54063  13.12771  1.000 21.06404 ? 161 VAL B N   1 
ATOM   3079 C CA  . VAL B 1 161 ? 31.87554  11.20341  14.48376  1.000 19.44877 ? 161 VAL B CA  1 
ATOM   3080 C C   . VAL B 1 161 ? 32.95955  11.74848  15.39813  1.000 25.55548 ? 161 VAL B C   1 
ATOM   3081 O O   . VAL B 1 161 ? 33.94503  12.31652  14.93239  1.000 22.62735 ? 161 VAL B O   1 
ATOM   3082 C CB  . VAL B 1 161 ? 31.69558  9.68031   14.68712  1.000 21.08805 ? 161 VAL B CB  1 
ATOM   3083 C CG1 . VAL B 1 161 ? 30.62331  9.11687   13.76643  1.000 20.11079 ? 161 VAL B CG1 1 
ATOM   3084 C CG2 . VAL B 1 161 ? 33.01523  8.97086   14.45572  1.000 15.82818 ? 161 VAL B CG2 1 
ATOM   3085 N N   . ASP B 1 162 ? 32.80872  11.53552  16.69995  1.000 15.67068 ? 162 ASP B N   1 
ATOM   3086 C CA  . ASP B 1 162 ? 33.93298  11.91225  17.54880  1.000 17.09079 ? 162 ASP B CA  1 
ATOM   3087 C C   . ASP B 1 162 ? 34.90599  10.76743  17.76799  1.000 21.94984 ? 162 ASP B C   1 
ATOM   3088 O O   . ASP B 1 162 ? 36.11849  10.99058  17.80179  1.000 22.94415 ? 162 ASP B O   1 
ATOM   3089 C CB  . ASP B 1 162 ? 33.42601  12.44011  18.88941  1.000 22.63886 ? 162 ASP B CB  1 
ATOM   3090 C CG  . ASP B 1 162 ? 32.65445  13.70912  18.72549  1.000 31.75129 ? 162 ASP B CG  1 
ATOM   3091 O OD1 . ASP B 1 162 ? 33.26092  14.68476  18.22802  1.000 33.03277 ? 162 ASP B OD1 1 
ATOM   3092 O OD2 . ASP B 1 162 ? 31.44098  13.72317  19.03727  1.000 28.36362 ? 162 ASP B OD2 1 
ATOM   3093 N N   . PHE B 1 163 ? 34.40847  9.54061   17.91912  1.000 23.08647 ? 163 PHE B N   1 
ATOM   3094 C CA  . PHE B 1 163 ? 35.26191  8.40158   18.20860  1.000 16.97960 ? 163 PHE B CA  1 
ATOM   3095 C C   . PHE B 1 163 ? 34.73850  7.17610   17.48826  1.000 17.70233 ? 163 PHE B C   1 
ATOM   3096 O O   . PHE B 1 163 ? 33.52409  6.98749   17.38085  1.000 13.24346 ? 163 PHE B O   1 
ATOM   3097 C CB  . PHE B 1 163 ? 35.31600  8.13159   19.70765  1.000 21.78129 ? 163 PHE B CB  1 
ATOM   3098 C CG  . PHE B 1 163 ? 35.86690  9.27030   20.49452  1.000 28.30869 ? 163 PHE B CG  1 
ATOM   3099 C CD1 . PHE B 1 163 ? 37.21232  9.56700   20.43624  1.000 20.04812 ? 163 PHE B CD1 1 
ATOM   3100 C CD2 . PHE B 1 163 ? 35.04018  10.05377  21.27294  1.000 22.51082 ? 163 PHE B CD2 1 
ATOM   3101 C CE1 . PHE B 1 163 ? 37.72708  10.62101  21.15293  1.000 27.50293 ? 163 PHE B CE1 1 
ATOM   3102 C CE2 . PHE B 1 163 ? 35.55279  11.10949  21.99495  1.000 28.07579 ? 163 PHE B CE2 1 
ATOM   3103 C CZ  . PHE B 1 163 ? 36.89891  11.38886  21.93641  1.000 28.06915 ? 163 PHE B CZ  1 
ATOM   3104 N N   . GLY B 1 164 ? 35.65902  6.35701   16.97416  1.000 15.54961 ? 164 GLY B N   1 
ATOM   3105 C CA  . GLY B 1 164 ? 35.28767  5.14795   16.27934  1.000 14.87047 ? 164 GLY B CA  1 
ATOM   3106 C C   . GLY B 1 164 ? 35.97284  3.94499   16.88142  1.000 14.22585 ? 164 GLY B C   1 
ATOM   3107 O O   . GLY B 1 164 ? 37.00467  4.04795   17.55503  1.000 17.62008 ? 164 GLY B O   1 
ATOM   3108 N N   . VAL B 1 165 ? 35.36159  2.78503   16.65734  1.000 16.36350 ? 165 VAL B N   1 
ATOM   3109 C CA  . VAL B 1 165 ? 35.97059  1.50214   16.97980  1.000 8.76110  ? 165 VAL B CA  1 
ATOM   3110 C C   . VAL B 1 165 ? 35.59476  0.52958   15.87792  1.000 14.21000 ? 165 VAL B C   1 
ATOM   3111 O O   . VAL B 1 165 ? 34.47486  0.57205   15.36116  1.000 14.88164 ? 165 VAL B O   1 
ATOM   3112 C CB  . VAL B 1 165 ? 35.53917  0.97803   18.36655  1.000 15.13546 ? 165 VAL B CB  1 
ATOM   3113 C CG1 . VAL B 1 165 ? 34.03664  0.75670   18.42354  1.000 11.24277 ? 165 VAL B CG1 1 
ATOM   3114 C CG2 . VAL B 1 165 ? 36.26209  -0.31089  18.69093  1.000 14.47939 ? 165 VAL B CG2 1 
ATOM   3115 N N   . ILE B 1 166 ? 36.54751  -0.30390  15.46685  1.000 12.69750 ? 166 ILE B N   1 
ATOM   3116 C CA  . ILE B 1 166 ? 36.27267  -1.39715  14.54325  1.000 11.68963 ? 166 ILE B CA  1 
ATOM   3117 C C   . ILE B 1 166 ? 36.71402  -2.69060  15.20868  1.000 13.67081 ? 166 ILE B C   1 
ATOM   3118 O O   . ILE B 1 166 ? 37.81423  -2.76472  15.76838  1.000 11.95898 ? 166 ILE B O   1 
ATOM   3119 C CB  . ILE B 1 166 ? 36.97172  -1.20694  13.18339  1.000 20.24063 ? 166 ILE B CB  1 
ATOM   3120 C CG1 . ILE B 1 166 ? 36.49004  0.09580   12.51517  1.000 21.60754 ? 166 ILE B CG1 1 
ATOM   3121 C CG2 . ILE B 1 166 ? 36.67985  -2.40966  12.26672  1.000 14.77447 ? 166 ILE B CG2 1 
ATOM   3122 C CD1 . ILE B 1 166 ? 37.22061  0.46343   11.20731  1.000 30.38864 ? 166 ILE B CD1 1 
ATOM   3123 N N   . HIS B 1 167 ? 35.84775  -3.69113  15.17477  1.000 8.63597  ? 167 HIS B N   1 
ATOM   3124 C CA  . HIS B 1 167 ? 36.15585  -5.02828  15.65206  1.000 12.93325 ? 167 HIS B CA  1 
ATOM   3125 C C   . HIS B 1 167 ? 36.15711  -5.97208  14.45538  1.000 13.58008 ? 167 HIS B C   1 
ATOM   3126 O O   . HIS B 1 167 ? 35.18023  -6.01823  13.70325  1.000 10.21314 ? 167 HIS B O   1 
ATOM   3127 C CB  . HIS B 1 167 ? 35.12056  -5.50399  16.68446  1.000 9.19343  ? 167 HIS B CB  1 
ATOM   3128 C CG  . HIS B 1 167 ? 35.07135  -4.68090  17.93724  1.000 17.48605 ? 167 HIS B CG  1 
ATOM   3129 N ND1 . HIS B 1 167 ? 36.12636  -4.61484  18.82776  1.000 13.03504 ? 167 HIS B ND1 1 
ATOM   3130 C CD2 . HIS B 1 167 ? 34.08895  -3.90473  18.46294  1.000 9.43689  ? 167 HIS B CD2 1 
ATOM   3131 C CE1 . HIS B 1 167 ? 35.80402  -3.82377  19.83395  1.000 11.02174 ? 167 HIS B CE1 1 
ATOM   3132 N NE2 . HIS B 1 167 ? 34.57178  -3.38352  19.64153  1.000 15.34485 ? 167 HIS B NE2 1 
ATOM   3133 N N   . LEU B 1 168 ? 37.25080  -6.70961  14.27804  1.000 13.90660 ? 168 LEU B N   1 
ATOM   3134 C CA  . LEU B 1 168 ? 37.32313  -7.75172  13.25579  1.000 13.05352 ? 168 LEU B CA  1 
ATOM   3135 C C   . LEU B 1 168 ? 36.52825  -8.96127  13.73775  1.000 14.83477 ? 168 LEU B C   1 
ATOM   3136 O O   . LEU B 1 168 ? 36.85368  -9.55391  14.77495  1.000 17.92780 ? 168 LEU B O   1 
ATOM   3137 C CB  . LEU B 1 168 ? 38.78246  -8.11736  12.98356  1.000 16.52889 ? 168 LEU B CB  1 
ATOM   3138 C CG  . LEU B 1 168 ? 39.33466  -8.57897  11.62255  1.000 29.65423 ? 168 LEU B CG  1 
ATOM   3139 C CD1 . LEU B 1 168 ? 39.86736  -9.98768  11.73719  1.000 17.93950 ? 168 LEU B CD1 1 
ATOM   3140 C CD2 . LEU B 1 168 ? 38.33659  -8.45098  10.45572  1.000 23.36625 ? 168 LEU B CD2 1 
ATOM   3141 N N   . MET B 1 169 ? 35.45110  -9.29437  13.02441  1.000 10.15170 ? 169 MET B N   1 
ATOM   3142 C CA  . MET B 1 169 ? 34.66952  -10.47398 13.35420  1.000 15.80175 ? 169 MET B CA  1 
ATOM   3143 C C   . MET B 1 169 ? 35.18407  -11.71331 12.64654  1.000 16.98507 ? 169 MET B C   1 
ATOM   3144 O O   . MET B 1 169 ? 35.07045  -12.81720 13.17641  1.000 15.11410 ? 169 MET B O   1 
ATOM   3145 C CB  . MET B 1 169 ? 33.19325  -10.27348 12.98117  1.000 17.67286 ? 169 MET B CB  1 
ATOM   3146 C CG  . MET B 1 169 ? 32.40701  -9.36097  13.89202  1.000 20.15375 ? 169 MET B CG  1 
ATOM   3147 S SD  . MET B 1 169 ? 32.34344  -9.89648  15.62529  1.000 24.47124 ? 169 MET B SD  1 
ATOM   3148 C CE  . MET B 1 169 ? 33.54232  -8.79748  16.30662  1.000 15.50674 ? 169 MET B CE  1 
ATOM   3149 N N   . GLY B 1 170 ? 35.73672  -11.55876 11.45613  1.000 22.52507 ? 170 GLY B N   1 
ATOM   3150 C CA  . GLY B 1 170 ? 36.11725  -12.71698 10.68595  1.000 19.57203 ? 170 GLY B CA  1 
ATOM   3151 C C   . GLY B 1 170 ? 36.84614  -12.30551 9.43675   1.000 19.70974 ? 170 GLY B C   1 
ATOM   3152 O O   . GLY B 1 170 ? 36.57205  -11.24656 8.86776   1.000 20.50179 ? 170 GLY B O   1 
ATOM   3153 N N   . ARG B 1 171 ? 37.79483  -13.13264 9.01398   1.000 24.75918 ? 171 ARG B N   1 
ATOM   3154 C CA  . ARG B 1 171 ? 38.58221  -12.87812 7.81428   1.000 30.55127 ? 171 ARG B CA  1 
ATOM   3155 C C   . ARG B 1 171 ? 38.84597  -14.23536 7.17581   1.000 35.45468 ? 171 ARG B C   1 
ATOM   3156 O O   . ARG B 1 171 ? 39.37894  -15.13349 7.83306   1.000 26.18778 ? 171 ARG B O   1 
ATOM   3157 C CB  . ARG B 1 171 ? 39.87739  -12.14144 8.18136   1.000 27.08713 ? 171 ARG B CB  1 
ATOM   3158 C CG  . ARG B 1 171 ? 40.72825  -11.63135 7.04282   1.000 32.87468 ? 171 ARG B CG  1 
ATOM   3159 C CD  . ARG B 1 171 ? 41.79876  -10.67163 7.57340   1.000 29.47902 ? 171 ARG B CD  1 
ATOM   3160 N NE  . ARG B 1 171 ? 43.02753  -10.68278 6.78208   1.000 33.56915 ? 171 ARG B NE  1 
ATOM   3161 C CZ  . ARG B 1 171 ? 43.40260  -9.70764  5.96671   1.000 39.06431 ? 171 ARG B CZ  1 
ATOM   3162 N NH1 . ARG B 1 171 ? 42.66108  -8.62133  5.80498   1.000 38.87599 ? 171 ARG B NH1 1 
ATOM   3163 N NH2 . ARG B 1 171 ? 44.55384  -9.81975  5.30177   1.000 30.59045 ? 171 ARG B NH2 1 
ATOM   3164 N N   . PHE B 1 172 ? 38.42601  -14.40597 5.92254   1.000 31.27878 ? 172 PHE B N   1 
ATOM   3165 C CA  . PHE B 1 172 ? 38.40330  -15.71556 5.27580   1.000 27.56578 ? 172 PHE B CA  1 
ATOM   3166 C C   . PHE B 1 172 ? 39.02339  -15.61102 3.89045   1.000 26.58798 ? 172 PHE B C   1 
ATOM   3167 O O   . PHE B 1 172 ? 38.50000  -14.89620 3.02755   1.000 23.84339 ? 172 PHE B O   1 
ATOM   3168 C CB  . PHE B 1 172 ? 36.97342  -16.25402 5.17422   1.000 24.79756 ? 172 PHE B CB  1 
ATOM   3169 C CG  . PHE B 1 172 ? 36.22373  -16.22518 6.47145   1.000 32.10349 ? 172 PHE B CG  1 
ATOM   3170 C CD1 . PHE B 1 172 ? 36.65558  -16.97923 7.55346   1.000 38.87010 ? 172 PHE B CD1 1 
ATOM   3171 C CD2 . PHE B 1 172 ? 35.08044  -15.44882 6.61118   1.000 32.14166 ? 172 PHE B CD2 1 
ATOM   3172 C CE1 . PHE B 1 172 ? 35.96655  -16.95261 8.75722   1.000 42.36310 ? 172 PHE B CE1 1 
ATOM   3173 C CE2 . PHE B 1 172 ? 34.38202  -15.41828 7.80917   1.000 37.85088 ? 172 PHE B CE2 1 
ATOM   3174 C CZ  . PHE B 1 172 ? 34.82444  -16.16842 8.88511   1.000 40.22561 ? 172 PHE B CZ  1 
ATOM   3175 N N   . ASN B 1 173 ? 40.12972  -16.32665 3.68084   1.000 25.37187 ? 173 ASN B N   1 
ATOM   3176 C CA  . ASN B 1 173 ? 40.75823  -16.43365 2.36128   1.000 25.60324 ? 173 ASN B CA  1 
ATOM   3177 C C   . ASN B 1 173 ? 41.12058  -15.05460 1.81122   1.000 27.44494 ? 173 ASN B C   1 
ATOM   3178 O O   . ASN B 1 173 ? 41.06417  -14.80697 0.60554   1.000 29.38928 ? 173 ASN B O   1 
ATOM   3179 C CB  . ASN B 1 173 ? 39.83974  -17.19704 1.39404   1.000 32.82656 ? 173 ASN B CB  1 
ATOM   3180 C CG  . ASN B 1 173 ? 40.51366  -17.53894 0.07535   1.000 29.46039 ? 173 ASN B CG  1 
ATOM   3181 O OD1 . ASN B 1 173 ? 41.61430  -18.08667 0.05356   1.000 30.68372 ? 173 ASN B OD1 1 
ATOM   3182 N ND2 . ASN B 1 173 ? 39.86570  -17.18176 -1.02960  1.000 24.82881 ? 173 ASN B ND2 1 
ATOM   3183 N N   . ALA B 1 174 ? 41.50653  -14.14563 2.70073   1.000 27.64134 ? 174 ALA B N   1 
ATOM   3184 C CA  . ALA B 1 174 ? 41.70970  -12.74582 2.34996   1.000 24.18038 ? 174 ALA B CA  1 
ATOM   3185 C C   . ALA B 1 174 ? 43.17875  -12.36295 2.45388   1.000 25.25549 ? 174 ALA B C   1 
ATOM   3186 O O   . ALA B 1 174 ? 43.82499  -12.62235 3.47233   1.000 31.51414 ? 174 ALA B O   1 
ATOM   3187 C CB  . ALA B 1 174 ? 40.88003  -11.83181 3.25507   1.000 23.11051 ? 174 ALA B CB  1 
ATOM   3188 N N   . ALA B 1 175 ? 43.69713  -11.74510 1.40036   1.000 31.45509 ? 175 ALA B N   1 
ATOM   3189 C CA  . ALA B 1 175 ? 44.92733  -10.97293 1.46008   1.000 29.62807 ? 175 ALA B CA  1 
ATOM   3190 C C   . ALA B 1 175 ? 44.56281  -9.49729  1.39365   1.000 22.46101 ? 175 ALA B C   1 
ATOM   3191 O O   . ALA B 1 175 ? 43.45100  -9.14144  1.01912   1.000 23.55184 ? 175 ALA B O   1 
ATOM   3192 C CB  . ALA B 1 175 ? 45.87843  -11.33872 0.31440   1.000 28.73833 ? 175 ALA B CB  1 
ATOM   3193 N N   . GLY B 1 176 ? 45.50566  -8.63828  1.75394   1.000 24.58447 ? 176 GLY B N   1 
ATOM   3194 C CA  . GLY B 1 176 ? 45.23125  -7.21742  1.77000   1.000 25.21769 ? 176 GLY B CA  1 
ATOM   3195 C C   . GLY B 1 176 ? 44.27562  -6.85713  2.89702   1.000 22.46287 ? 176 GLY B C   1 
ATOM   3196 O O   . GLY B 1 176 ? 44.13799  -7.56892  3.88986   1.000 29.56777 ? 176 GLY B O   1 
ATOM   3197 N N   . GLY B 1 177 ? 43.60014  -5.72810  2.72406   1.000 31.12752 ? 177 GLY B N   1 
ATOM   3198 C CA  . GLY B 1 177 ? 42.68404  -5.25353  3.74251   1.000 28.61715 ? 177 GLY B CA  1 
ATOM   3199 C C   . GLY B 1 177 ? 43.33731  -4.54708  4.89997   1.000 27.19117 ? 177 GLY B C   1 
ATOM   3200 O O   . GLY B 1 177 ? 42.75225  -4.49665  5.98907   1.000 25.78599 ? 177 GLY B O   1 
ATOM   3201 N N   . GLU B 1 178 ? 44.53642  -3.99973  4.70347   1.000 17.22760 ? 178 GLU B N   1 
ATOM   3202 C CA  . GLU B 1 178 ? 45.23251  -3.33677  5.79541   1.000 20.89493 ? 178 GLU B CA  1 
ATOM   3203 C C   . GLU B 1 178 ? 44.49566  -2.07024  6.18654   1.000 19.52850 ? 178 GLU B C   1 
ATOM   3204 O O   . GLU B 1 178 ? 43.95746  -1.35918  5.33570   1.000 22.61560 ? 178 GLU B O   1 
ATOM   3205 C CB  . GLU B 1 178 ? 46.66981  -2.98703  5.39785   1.000 23.51558 ? 178 GLU B CB  1 
ATOM   3206 C CG  . GLU B 1 178 ? 47.56636  -4.18344  5.13079   1.000 24.52215 ? 178 GLU B CG  1 
ATOM   3207 C CD  . GLU B 1 178 ? 47.56850  -4.61910  3.67177   1.000 28.47341 ? 178 GLU B CD  1 
ATOM   3208 O OE1 . GLU B 1 178 ? 46.57380  -4.36874  2.94570   1.000 23.31391 ? 178 GLU B OE1 1 
ATOM   3209 O OE2 . GLU B 1 178 ? 48.58019  -5.21239  3.25133   1.000 33.08577 ? 178 GLU B OE2 1 
ATOM   3210 N N   . SER B 1 179 ? 44.47495  -1.78903  7.48511   1.000 19.64612 ? 179 SER B N   1 
ATOM   3211 C CA  . SER B 1 179 ? 43.96956  -0.51208  7.96132   1.000 26.26806 ? 179 SER B CA  1 
ATOM   3212 C C   . SER B 1 179 ? 45.07274  0.52941   7.88166   1.000 21.46472 ? 179 SER B C   1 
ATOM   3213 O O   . SER B 1 179 ? 46.23718  0.24192   8.16584   1.000 22.51463 ? 179 SER B O   1 
ATOM   3214 C CB  . SER B 1 179 ? 43.46017  -0.62951  9.40208   1.000 25.14517 ? 179 SER B CB  1 
ATOM   3215 O OG  . SER B 1 179 ? 42.69790  -1.80781  9.56180   1.000 22.83618 ? 179 SER B OG  1 
ATOM   3216 N N   . GLN B 1 180 ? 44.69853  1.74516   7.50464   1.000 17.87954 ? 180 GLN B N   1 
ATOM   3217 C CA  . GLN B 1 180 ? 45.64607  2.82545   7.28259   1.000 23.50984 ? 180 GLN B CA  1 
ATOM   3218 C C   . GLN B 1 180 ? 45.25310  4.04425   8.10296   1.000 22.08123 ? 180 GLN B C   1 
ATOM   3219 O O   . GLN B 1 180 ? 44.09076  4.45834   8.08787   1.000 19.88439 ? 180 GLN B O   1 
ATOM   3220 C CB  . GLN B 1 180 ? 45.70509  3.19708   5.79808   1.000 22.73891 ? 180 GLN B CB  1 
ATOM   3221 C CG  . GLN B 1 180 ? 46.11896  2.05962   4.88883   1.000 20.47907 ? 180 GLN B CG  1 
ATOM   3222 C CD  . GLN B 1 180 ? 46.21042  2.49952   3.44038   1.000 29.98350 ? 180 GLN B CD  1 
ATOM   3223 O OE1 . GLN B 1 180 ? 45.25032  3.03827   2.88219   1.000 36.96102 ? 180 GLN B OE1 1 
ATOM   3224 N NE2 . GLN B 1 180 ? 47.37124  2.29181   2.82828   1.000 33.76210 ? 180 GLN B NE2 1 
ATOM   3225 N N   . VAL B 1 181 ? 46.22386  4.62653   8.79744   1.000 19.73339 ? 181 VAL B N   1 
ATOM   3226 C CA  . VAL B 1 181 ? 46.03393  5.87212   9.53317   1.000 24.37464 ? 181 VAL B CA  1 
ATOM   3227 C C   . VAL B 1 181 ? 46.82316  6.96968   8.83741   1.000 25.29141 ? 181 VAL B C   1 
ATOM   3228 O O   . VAL B 1 181 ? 48.02041  6.81137   8.57951   1.000 24.79381 ? 181 VAL B O   1 
ATOM   3229 C CB  . VAL B 1 181 ? 46.46771  5.73130   10.99917  1.000 27.56799 ? 181 VAL B CB  1 
ATOM   3230 C CG1 . VAL B 1 181 ? 46.41866  7.08686   11.69161  1.000 33.31867 ? 181 VAL B CG1 1 
ATOM   3231 C CG2 . VAL B 1 181 ? 45.57183  4.72169   11.70839  1.000 28.21879 ? 181 VAL B CG2 1 
ATOM   3232 N N   . TYR B 1 182 ? 46.14945  8.06776   8.51747   1.000 34.37131 ? 182 TYR B N   1 
ATOM   3233 C CA  . TYR B 1 182 ? 46.76379  9.22098   7.87603   1.000 35.64609 ? 182 TYR B CA  1 
ATOM   3234 C C   . TYR B 1 182 ? 46.71790  10.42273  8.80494   1.000 33.30449 ? 182 TYR B C   1 
ATOM   3235 O O   . TYR B 1 182 ? 45.87107  10.50679  9.69800   1.000 32.32727 ? 182 TYR B O   1 
ATOM   3236 C CB  . TYR B 1 182 ? 46.05285  9.59378   6.56924   1.000 28.45348 ? 182 TYR B CB  1 
ATOM   3237 C CG  . TYR B 1 182 ? 46.16438  8.56062   5.47757   1.000 28.11525 ? 182 TYR B CG  1 
ATOM   3238 C CD1 . TYR B 1 182 ? 45.32489  7.46369   5.45560   1.000 23.87121 ? 182 TYR B CD1 1 
ATOM   3239 C CD2 . TYR B 1 182 ? 47.10215  8.69584   4.45591   1.000 29.36088 ? 182 TYR B CD2 1 
ATOM   3240 C CE1 . TYR B 1 182 ? 45.41415  6.52099   4.45482   1.000 38.37973 ? 182 TYR B CE1 1 
ATOM   3241 C CE2 . TYR B 1 182 ? 47.20488  7.75838   3.44888   1.000 32.81056 ? 182 TYR B CE2 1 
ATOM   3242 C CZ  . TYR B 1 182 ? 46.35935  6.66976   3.45187   1.000 41.36305 ? 182 TYR B CZ  1 
ATOM   3243 O OH  . TYR B 1 182 ? 46.45038  5.72457   2.45633   1.000 36.28268 ? 182 TYR B OH  1 
ATOM   3244 N N   . SER B 1 183 ? 47.64128  11.35065  8.57885   1.000 33.00992 ? 183 SER B N   1 
ATOM   3245 C CA  . SER B 1 183 ? 47.58023  12.66072  9.19807   1.000 32.83931 ? 183 SER B CA  1 
ATOM   3246 C C   . SER B 1 183 ? 46.45106  13.47244  8.57507   1.000 34.71202 ? 183 SER B C   1 
ATOM   3247 O O   . SER B 1 183 ? 45.90571  13.12802  7.52062   1.000 27.32963 ? 183 SER B O   1 
ATOM   3248 C CB  . SER B 1 183 ? 48.90478  13.39911  9.01364   1.000 43.77630 ? 183 SER B CB  1 
ATOM   3249 O OG  . SER B 1 183 ? 49.15498  13.61503  7.63381   1.000 38.69498 ? 183 SER B OG  1 
ATOM   3250 N N   . LEU B 1 184 ? 46.10158  14.57810  9.23414   1.000 34.02057 ? 184 LEU B N   1 
ATOM   3251 C CA  . LEU B 1 184 ? 45.14467  15.49100  8.62296   1.000 40.73932 ? 184 LEU B CA  1 
ATOM   3252 C C   . LEU B 1 184 ? 45.69297  16.11181  7.34648   1.000 40.29531 ? 184 LEU B C   1 
ATOM   3253 O O   . LEU B 1 184 ? 44.92875  16.72010  6.59173   1.000 30.18594 ? 184 LEU B O   1 
ATOM   3254 C CB  . LEU B 1 184 ? 44.74027  16.58847  9.61150   1.000 41.44745 ? 184 LEU B CB  1 
ATOM   3255 C CG  . LEU B 1 184 ? 43.95374  16.16435  10.85635  1.000 46.17904 ? 184 LEU B CG  1 
ATOM   3256 C CD1 . LEU B 1 184 ? 43.37298  17.38601  11.55990  1.000 42.00911 ? 184 LEU B CD1 1 
ATOM   3257 C CD2 . LEU B 1 184 ? 42.85272  15.18120  10.48444  1.000 36.38382 ? 184 LEU B CD2 1 
ATOM   3258 N N   . GLU B 1 185 ? 46.99676  15.97271  7.10148   1.000 44.89404 ? 185 GLU B N   1 
ATOM   3259 C CA  . GLU B 1 185 ? 47.63819  16.41098  5.87098   1.000 45.93017 ? 185 GLU B CA  1 
ATOM   3260 C C   . GLU B 1 185 ? 47.48887  15.39499  4.74839   1.000 47.08697 ? 185 GLU B C   1 
ATOM   3261 O O   . GLU B 1 185 ? 47.88932  15.68746  3.61657   1.000 40.76062 ? 185 GLU B O   1 
ATOM   3262 C CB  . GLU B 1 185 ? 49.12375  16.69001  6.13450   1.000 37.58704 ? 185 GLU B CB  1 
ATOM   3263 C CG  . GLU B 1 185 ? 49.38489  17.91626  7.02670   1.000 54.05194 ? 185 GLU B CG  1 
ATOM   3264 C CD  . GLU B 1 185 ? 48.87520  17.74659  8.45558   1.000 58.56939 ? 185 GLU B CD  1 
ATOM   3265 O OE1 . GLU B 1 185 ? 48.84290  16.59342  8.93655   1.000 55.07911 ? 185 GLU B OE1 1 
ATOM   3266 O OE2 . GLU B 1 185 ? 48.49155  18.75883  9.08889   1.000 57.51021 ? 185 GLU B OE2 1 
ATOM   3267 N N   . ARG B 1 186 ? 46.92704  14.21996  5.05032   1.000 44.59864 ? 186 ARG B N   1 
ATOM   3268 C CA  . ARG B 1 186 ? 46.66040  13.12859  4.11325   1.000 37.86843 ? 186 ARG B CA  1 
ATOM   3269 C C   . ARG B 1 186 ? 47.93437  12.36005  3.78224   1.000 38.13223 ? 186 ARG B C   1 
ATOM   3270 O O   . ARG B 1 186 ? 48.03608  11.72528  2.72723   1.000 35.52268 ? 186 ARG B O   1 
ATOM   3271 C CB  . ARG B 1 186 ? 45.97235  13.64562  2.84988   1.000 35.67091 ? 186 ARG B CB  1 
ATOM   3272 C CG  . ARG B 1 186 ? 44.63855  14.31291  3.15109   1.000 37.49577 ? 186 ARG B CG  1 
ATOM   3273 C CD  . ARG B 1 186 ? 44.05275  14.98663  1.93519   1.000 49.46549 ? 186 ARG B CD  1 
ATOM   3274 N NE  . ARG B 1 186 ? 43.70521  14.02080  0.90295   1.000 52.40341 ? 186 ARG B NE  1 
ATOM   3275 C CZ  . ARG B 1 186 ? 42.57290  13.33233  0.87487   1.000 48.71973 ? 186 ARG B CZ  1 
ATOM   3276 N NH1 . ARG B 1 186 ? 41.65153  13.47753  1.81206   1.000 42.45156 ? 186 ARG B NH1 1 
ATOM   3277 N NH2 . ARG B 1 186 ? 42.36092  12.47481  -0.11712  1.000 46.54373 ? 186 ARG B NH2 1 
ATOM   3278 N N   . GLU B 1 187 ? 48.88477  12.37489  4.71130   1.000 32.85644 ? 187 GLU B N   1 
ATOM   3279 C CA  . GLU B 1 187 ? 50.11863  11.60753  4.61485   1.000 34.46126 ? 187 GLU B CA  1 
ATOM   3280 C C   . GLU B 1 187 ? 50.01305  10.35753  5.48691   1.000 47.80148 ? 187 GLU B C   1 
ATOM   3281 O O   . GLU B 1 187 ? 49.59804  10.44488  6.64804   1.000 43.76410 ? 187 GLU B O   1 
ATOM   3282 C CB  . GLU B 1 187 ? 51.30684  12.46871  5.05403   1.000 38.66013 ? 187 GLU B CB  1 
ATOM   3283 C CG  . GLU B 1 187 ? 52.24779  12.90596  3.92357   1.000 55.12078 ? 187 GLU B CG  1 
ATOM   3284 C CD  . GLU B 1 187 ? 51.61982  13.87313  2.92068   1.000 64.14687 ? 187 GLU B CD  1 
ATOM   3285 O OE1 . GLU B 1 187 ? 51.13355  14.94067  3.34717   1.000 59.86446 ? 187 GLU B OE1 1 
ATOM   3286 O OE2 . GLU B 1 187 ? 51.62281  13.56737  1.70247   1.000 51.90382 ? 187 GLU B OE2 1 
ATOM   3287 N N   . LEU B 1 188 ? 50.41312  9.20450   4.94121   1.000 32.76869 ? 188 LEU B N   1 
ATOM   3288 C CA  . LEU B 1 188 ? 50.28734  7.94199   5.66238   1.000 32.13812 ? 188 LEU B CA  1 
ATOM   3289 C C   . LEU B 1 188 ? 51.26519  7.89595   6.82942   1.000 39.89505 ? 188 LEU B C   1 
ATOM   3290 O O   . LEU B 1 188 ? 52.46861  8.08335   6.64768   1.000 36.98482 ? 188 LEU B O   1 
ATOM   3291 C CB  . LEU B 1 188 ? 50.53359  6.77082   4.71841   1.000 39.35548 ? 188 LEU B CB  1 
ATOM   3292 C CG  . LEU B 1 188 ? 50.41632  5.35353   5.29600   1.000 44.80465 ? 188 LEU B CG  1 
ATOM   3293 C CD1 . LEU B 1 188 ? 48.99963  5.04441   5.77418   1.000 28.00143 ? 188 LEU B CD1 1 
ATOM   3294 C CD2 . LEU B 1 188 ? 50.86567  4.30996   4.28197   1.000 36.04512 ? 188 LEU B CD2 1 
ATOM   3295 N N   . VAL B 1 189 ? 50.74948  7.63982   8.03049   1.000 37.84541 ? 189 VAL B N   1 
ATOM   3296 C CA  . VAL B 1 189 ? 51.59490  7.54722   9.21370   1.000 27.37998 ? 189 VAL B CA  1 
ATOM   3297 C C   . VAL B 1 189 ? 51.68590  6.12156   9.73367   1.000 35.55424 ? 189 VAL B C   1 
ATOM   3298 O O   . VAL B 1 189 ? 52.68489  5.79452   10.40563  1.000 30.38509 ? 189 VAL B O   1 
ATOM   3299 C CB  . VAL B 1 189 ? 51.10627  8.49488   10.32451  1.000 33.79576 ? 189 VAL B CB  1 
ATOM   3300 C CG1 . VAL B 1 189 ? 50.94265  9.90351   9.78704   1.000 49.59599 ? 189 VAL B CG1 1 
ATOM   3301 C CG2 . VAL B 1 189 ? 49.80743  8.00258   10.91951  1.000 37.48111 ? 189 VAL B CG2 1 
ATOM   3302 N N   . ALA B 1 190 ? 50.71051  5.27110   9.47635   1.000 25.02963 ? 190 ALA B N   1 
ATOM   3303 C CA  . ALA B 1 190 ? 50.76518  3.93386   10.03296  1.000 25.24682 ? 190 ALA B CA  1 
ATOM   3304 C C   . ALA B 1 190 ? 49.85295  3.02942   9.22487   1.000 27.28777 ? 190 ALA B C   1 
ATOM   3305 O O   . ALA B 1 190 ? 48.84350  3.47239   8.66842   1.000 25.17701 ? 190 ALA B O   1 
ATOM   3306 C CB  . ALA B 1 190 ? 50.37316  3.93334   11.51762  1.000 29.57108 ? 190 ALA B CB  1 
ATOM   3307 N N   . GLU B 1 191 ? 50.22805  1.75809   9.17021   1.000 24.61647 ? 191 GLU B N   1 
ATOM   3308 C CA  . GLU B 1 191 ? 49.45577  0.73644   8.48248   1.000 32.80694 ? 191 GLU B CA  1 
ATOM   3309 C C   . GLU B 1 191 ? 49.57707  -0.55253  9.28205   1.000 27.89023 ? 191 GLU B C   1 
ATOM   3310 O O   . GLU B 1 191 ? 50.67508  -0.92421  9.70590   1.000 26.84769 ? 191 GLU B O   1 
ATOM   3311 C CB  . GLU B 1 191 ? 49.95492  0.55708   7.03806   1.000 26.34553 ? 191 GLU B CB  1 
ATOM   3312 C CG  . GLU B 1 191 ? 49.13648  -0.39263  6.19317   1.000 34.91575 ? 191 GLU B CG  1 
ATOM   3313 C CD  . GLU B 1 191 ? 49.56380  -0.39275  4.73442   1.000 30.82950 ? 191 GLU B CD  1 
ATOM   3314 O OE1 . GLU B 1 191 ? 49.38402  0.64186   4.04800   1.000 29.97048 ? 191 GLU B OE1 1 
ATOM   3315 O OE2 . GLU B 1 191 ? 50.08503  -1.43070  4.28429   1.000 33.17420 ? 191 GLU B OE2 1 
ATOM   3316 N N   . PHE B 1 192 ? 48.44534  -1.20528  9.53080   1.000 27.57625 ? 192 PHE B N   1 
ATOM   3317 C CA  . PHE B 1 192 ? 48.42460  -2.45160  10.28356  1.000 24.31829 ? 192 PHE B CA  1 
ATOM   3318 C C   . PHE B 1 192 ? 47.28708  -3.28416  9.73114   1.000 18.97996 ? 192 PHE B C   1 
ATOM   3319 O O   . PHE B 1 192 ? 46.47257  -2.80452  8.94475   1.000 23.22661 ? 192 PHE B O   1 
ATOM   3320 C CB  . PHE B 1 192 ? 48.24675  -2.20132  11.78408  1.000 25.18991 ? 192 PHE B CB  1 
ATOM   3321 C CG  . PHE B 1 192 ? 47.20413  -1.17713  12.08592  1.000 22.57548 ? 192 PHE B CG  1 
ATOM   3322 C CD1 . PHE B 1 192 ? 45.87077  -1.53070  12.15920  1.000 23.16994 ? 192 PHE B CD1 1 
ATOM   3323 C CD2 . PHE B 1 192 ? 47.55308  0.15848   12.24118  1.000 28.71374 ? 192 PHE B CD2 1 
ATOM   3324 C CE1 . PHE B 1 192 ? 44.90351  -0.56848  12.41554  1.000 24.41294 ? 192 PHE B CE1 1 
ATOM   3325 C CE2 . PHE B 1 192 ? 46.59608  1.12077   12.49058  1.000 31.85815 ? 192 PHE B CE2 1 
ATOM   3326 C CZ  . PHE B 1 192 ? 45.27237  0.76300   12.57542  1.000 23.31000 ? 192 PHE B CZ  1 
ATOM   3327 N N   . CYS B 1 193 ? 47.22549  -4.54214  10.14116  1.000 22.74523 ? 193 CYS B N   1 
ATOM   3328 C CA  . CYS B 1 193 ? 46.22704  -5.44204  9.58124   1.000 36.94582 ? 193 CYS B CA  1 
ATOM   3329 C C   . CYS B 1 193 ? 45.51499  -6.18581  10.69756  1.000 30.14591 ? 193 CYS B C   1 
ATOM   3330 O O   . CYS B 1 193 ? 46.13342  -6.97585  11.41886  1.000 26.00446 ? 193 CYS B O   1 
ATOM   3331 C CB  . CYS B 1 193 ? 46.84877  -6.42486  8.58749   1.000 26.45957 ? 193 CYS B CB  1 
ATOM   3332 S SG  . CYS B 1 193 ? 45.55554  -7.11233  7.52864   1.000 30.97828 ? 193 CYS B SG  1 
ATOM   3333 N N   . LEU B 1 194 ? 44.21273  -5.94465  10.81717  1.000 29.81438 ? 194 LEU B N   1 
ATOM   3334 C CA  . LEU B 1 194 ? 43.37820  -6.76129  11.68001  1.000 21.40368 ? 194 LEU B CA  1 
ATOM   3335 C C   . LEU B 1 194 ? 43.22931  -8.14910  11.06220  1.000 26.62141 ? 194 LEU B C   1 
ATOM   3336 O O   . LEU B 1 194 ? 42.74218  -8.28249  9.93500   1.000 20.88612 ? 194 LEU B O   1 
ATOM   3337 C CB  . LEU B 1 194 ? 42.01255  -6.08976  11.86566  1.000 16.93450 ? 194 LEU B CB  1 
ATOM   3338 C CG  . LEU B 1 194 ? 41.96238  -4.60919  12.28476  1.000 17.83935 ? 194 LEU B CG  1 
ATOM   3339 C CD1 . LEU B 1 194 ? 40.52872  -4.10614  12.45581  1.000 23.12860 ? 194 LEU B CD1 1 
ATOM   3340 C CD2 . LEU B 1 194 ? 42.76473  -4.35547  13.53910  1.000 21.24873 ? 194 LEU B CD2 1 
ATOM   3341 N N   . THR B 1 195 ? 43.65363  -9.18379  11.79304  1.000 16.82978 ? 195 THR B N   1 
ATOM   3342 C CA  . THR B 1 195 ? 43.61795  -10.53522 11.24045  1.000 26.77451 ? 195 THR B CA  1 
ATOM   3343 C C   . THR B 1 195 ? 42.92215  -11.54595 12.14110  1.000 22.82135 ? 195 THR B C   1 
ATOM   3344 O O   . THR B 1 195 ? 42.32422  -12.49670 11.63748  1.000 26.00668 ? 195 THR B O   1 
ATOM   3345 C CB  . THR B 1 195 ? 45.03682  -11.04653 10.92838  1.000 34.92940 ? 195 THR B CB  1 
ATOM   3346 O OG1 . THR B 1 195 ? 45.91476  -10.74948 12.02741  1.000 41.13582 ? 195 THR B OG1 1 
ATOM   3347 C CG2 . THR B 1 195 ? 45.56371  -10.40675 9.65346   1.000 30.16465 ? 195 THR B CG2 1 
ATOM   3348 N N   . GLU B 1 196 ? 42.98813  -11.37328 13.45918  1.000 25.24602 ? 196 GLU B N   1 
ATOM   3349 C CA  . GLU B 1 196 ? 42.38245  -12.32680 14.38061  1.000 22.45900 ? 196 GLU B CA  1 
ATOM   3350 C C   . GLU B 1 196 ? 41.02119  -11.83016 14.86026  1.000 21.11961 ? 196 GLU B C   1 
ATOM   3351 O O   . GLU B 1 196 ? 40.80569  -10.62423 15.01129  1.000 18.33744 ? 196 GLU B O   1 
ATOM   3352 C CB  . GLU B 1 196 ? 43.30502  -12.58735 15.57098  1.000 21.49384 ? 196 GLU B CB  1 
ATOM   3353 C CG  . GLU B 1 196 ? 44.69103  -13.03685 15.13943  1.000 32.09102 ? 196 GLU B CG  1 
ATOM   3354 C CD  . GLU B 1 196 ? 44.64120  -14.28596 14.26957  1.000 30.31827 ? 196 GLU B CD  1 
ATOM   3355 O OE1 . GLU B 1 196 ? 43.93043  -15.24800 14.63021  1.000 39.35105 ? 196 GLU B OE1 1 
ATOM   3356 O OE2 . GLU B 1 196 ? 45.30501  -14.30054 13.21726  1.000 51.22980 ? 196 GLU B OE2 1 
ATOM   3357 N N   . GLN B 1 197 ? 40.10259  -12.77129 15.07748  1.000 22.90850 ? 197 GLN B N   1 
ATOM   3358 C CA  . GLN B 1 197 ? 38.77183  -12.44170 15.56718  1.000 20.05046 ? 197 GLN B CA  1 
ATOM   3359 C C   . GLN B 1 197 ? 38.86952  -11.63288 16.85405  1.000 26.37356 ? 197 GLN B C   1 
ATOM   3360 O O   . GLN B 1 197 ? 39.56466  -12.02671 17.80036  1.000 16.60100 ? 197 GLN B O   1 
ATOM   3361 C CB  . GLN B 1 197 ? 37.96562  -13.71773 15.80373  1.000 22.08236 ? 197 GLN B CB  1 
ATOM   3362 C CG  . GLN B 1 197 ? 36.61276  -13.43417 16.43724  1.000 22.61109 ? 197 GLN B CG  1 
ATOM   3363 C CD  . GLN B 1 197 ? 35.70102  -14.63564 16.45729  1.000 22.76376 ? 197 GLN B CD  1 
ATOM   3364 O OE1 . GLN B 1 197 ? 35.78517  -15.48039 17.35333  1.000 24.51482 ? 197 GLN B OE1 1 
ATOM   3365 N NE2 . GLN B 1 197 ? 34.80886  -14.71780 15.46947  1.000 21.47735 ? 197 GLN B NE2 1 
ATOM   3366 N N   . MET B 1 198 ? 38.18781  -10.48507 16.86145  1.000 14.72121 ? 198 MET B N   1 
ATOM   3367 C CA  . MET B 1 198 ? 38.16972  -9.44932  17.90755  1.000 18.36326 ? 198 MET B CA  1 
ATOM   3368 C C   . MET B 1 198 ? 39.41051  -8.56706  17.92353  1.000 18.84744 ? 198 MET B C   1 
ATOM   3369 O O   . MET B 1 198 ? 39.55415  -7.78263  18.86661  1.000 15.57295 ? 198 MET B O   1 
ATOM   3370 C CB  . MET B 1 198 ? 37.96227  -9.99522  19.32757  1.000 14.78708 ? 198 MET B CB  1 
ATOM   3371 C CG  . MET B 1 198 ? 36.51530  -10.30395 19.67994  1.000 20.38279 ? 198 MET B CG  1 
ATOM   3372 S SD  . MET B 1 198 ? 35.33871  -9.00107  19.22856  1.000 28.20188 ? 198 MET B SD  1 
ATOM   3373 C CE  . MET B 1 198 ? 35.74725  -7.68960  20.36233  1.000 16.45393 ? 198 MET B CE  1 
ATOM   3374 N N   . ASP B 1 199 ? 40.30485  -8.64411  16.93065  1.000 17.85576 ? 199 ASP B N   1 
ATOM   3375 C CA  . ASP B 1 199 ? 41.27160  -7.56425  16.74489  1.000 19.54661 ? 199 ASP B CA  1 
ATOM   3376 C C   . ASP B 1 199 ? 40.51345  -6.25518  16.60197  1.000 15.31964 ? 199 ASP B C   1 
ATOM   3377 O O   . ASP B 1 199 ? 39.49487  -6.18632  15.90393  1.000 14.42920 ? 199 ASP B O   1 
ATOM   3378 C CB  . ASP B 1 199 ? 42.15913  -7.78728  15.50419  1.000 16.38942 ? 199 ASP B CB  1 
ATOM   3379 C CG  . ASP B 1 199 ? 43.30201  -8.76971  15.75379  1.000 21.22482 ? 199 ASP B CG  1 
ATOM   3380 O OD1 . ASP B 1 199 ? 43.46047  -9.23020  16.90325  1.000 16.92488 ? 199 ASP B OD1 1 
ATOM   3381 O OD2 . ASP B 1 199 ? 44.03814  -9.08733  14.78754  1.000 21.60012 ? 199 ASP B OD2 1 
ATOM   3382 N N   . THR B 1 200 ? 41.00255  -5.22066  17.28032  1.000 16.96958 ? 200 THR B N   1 
ATOM   3383 C CA  . THR B 1 200 ? 40.23092  -3.99917  17.46199  1.000 16.21052 ? 200 THR B CA  1 
ATOM   3384 C C   . THR B 1 200 ? 41.10529  -2.78407  17.21297  1.000 18.11350 ? 200 THR B C   1 
ATOM   3385 O O   . THR B 1 200 ? 42.28159  -2.76659  17.59213  1.000 22.30845 ? 200 THR B O   1 
ATOM   3386 C CB  . THR B 1 200 ? 39.63859  -3.92584  18.88446  1.000 15.23918 ? 200 THR B CB  1 
ATOM   3387 O OG1 . THR B 1 200 ? 38.71028  -5.00943  19.06334  1.000 18.90235 ? 200 THR B OG1 1 
ATOM   3388 C CG2 . THR B 1 200 ? 38.92690  -2.58857  19.10779  1.000 10.53815 ? 200 THR B CG2 1 
ATOM   3389 N N   . MET B 1 201 ? 40.52189  -1.77060  16.57776  1.000 14.33771 ? 201 MET B N   1 
ATOM   3390 C CA  . MET B 1 201 ? 41.15159  -0.46903  16.38845  1.000 18.20169 ? 201 MET B CA  1 
ATOM   3391 C C   . MET B 1 201 ? 40.21226  0.61383   16.90089  1.000 17.60325 ? 201 MET B C   1 
ATOM   3392 O O   . MET B 1 201 ? 39.04152  0.65469   16.51365  1.000 17.24968 ? 201 MET B O   1 
ATOM   3393 C CB  . MET B 1 201 ? 41.48049  -0.23084  14.90907  1.000 20.08887 ? 201 MET B CB  1 
ATOM   3394 C CG  . MET B 1 201 ? 41.64061  1.24306   14.48901  1.000 25.89700 ? 201 MET B CG  1 
ATOM   3395 S SD  . MET B 1 201 ? 41.74660  1.36666   12.67649  1.000 30.42179 ? 201 MET B SD  1 
ATOM   3396 C CE  . MET B 1 201 ? 41.69520  3.14176   12.42234  1.000 33.05594 ? 201 MET B CE  1 
ATOM   3397 N N   . PHE B 1 202 ? 40.72395  1.47796   17.77623  1.000 20.59648 ? 202 PHE B N   1 
ATOM   3398 C CA  . PHE B 1 202 ? 40.03105  2.66218   18.26751  1.000 19.04933 ? 202 PHE B CA  1 
ATOM   3399 C C   . PHE B 1 202 ? 40.62107  3.89237   17.58924  1.000 24.22196 ? 202 PHE B C   1 
ATOM   3400 O O   . PHE B 1 202 ? 41.82793  3.94710   17.34001  1.000 18.36938 ? 202 PHE B O   1 
ATOM   3401 C CB  . PHE B 1 202 ? 40.19156  2.81840   19.78963  1.000 16.33193 ? 202 PHE B CB  1 
ATOM   3402 C CG  . PHE B 1 202 ? 39.73424  1.63314   20.59509  1.000 20.54792 ? 202 PHE B CG  1 
ATOM   3403 C CD1 . PHE B 1 202 ? 38.38601  1.44404   20.87878  1.000 16.23885 ? 202 PHE B CD1 1 
ATOM   3404 C CD2 . PHE B 1 202 ? 40.65589  0.72988   21.11172  1.000 19.54661 ? 202 PHE B CD2 1 
ATOM   3405 C CE1 . PHE B 1 202 ? 37.96398  0.36139   21.63362  1.000 13.81512 ? 202 PHE B CE1 1 
ATOM   3406 C CE2 . PHE B 1 202 ? 40.23788  -0.35245  21.86187  1.000 19.98918 ? 202 PHE B CE2 1 
ATOM   3407 C CZ  . PHE B 1 202 ? 38.88193  -0.53685  22.11937  1.000 19.78512 ? 202 PHE B CZ  1 
ATOM   3408 N N   . TRP B 1 203 ? 39.79073  4.90390   17.32133  1.000 15.40428 ? 203 TRP B N   1 
ATOM   3409 C CA  . TRP B 1 203 ? 40.39898  6.11135   16.77738  1.000 19.61808 ? 203 TRP B CA  1 
ATOM   3410 C C   . TRP B 1 203 ? 39.58845  7.34911   17.13334  1.000 20.91439 ? 203 TRP B C   1 
ATOM   3411 O O   . TRP B 1 203 ? 38.38925  7.27814   17.43313  1.000 19.41515 ? 203 TRP B O   1 
ATOM   3412 C CB  . TRP B 1 203 ? 40.60926  6.00009   15.24964  1.000 21.97261 ? 203 TRP B CB  1 
ATOM   3413 C CG  . TRP B 1 203 ? 39.38844  6.21769   14.40407  1.000 16.50233 ? 203 TRP B CG  1 
ATOM   3414 C CD1 . TRP B 1 203 ? 39.01049  7.37068   13.80645  1.000 14.72470 ? 203 TRP B CD1 1 
ATOM   3415 C CD2 . TRP B 1 203 ? 38.41261  5.23362   14.04018  1.000 16.96931 ? 203 TRP B CD2 1 
ATOM   3416 N NE1 . TRP B 1 203 ? 37.84952  7.18046   13.10028  1.000 15.42104 ? 203 TRP B NE1 1 
ATOM   3417 C CE2 . TRP B 1 203 ? 37.45529  5.87735   13.23759  1.000 19.25060 ? 203 TRP B CE2 1 
ATOM   3418 C CE3 . TRP B 1 203 ? 38.25506  3.87195   14.32514  1.000 16.08786 ? 203 TRP B CE3 1 
ATOM   3419 C CZ2 . TRP B 1 203 ? 36.34829  5.21187   12.71019  1.000 21.41086 ? 203 TRP B CZ2 1 
ATOM   3420 C CZ3 . TRP B 1 203 ? 37.15900  3.20859   13.79748  1.000 16.55000 ? 203 TRP B CZ3 1 
ATOM   3421 C CH2 . TRP B 1 203 ? 36.21911  3.88390   12.99674  1.000 17.02884 ? 203 TRP B CH2 1 
ATOM   3422 N N   . SER B 1 204 ? 40.28461  8.48552   17.14475  1.000 22.22801 ? 204 SER B N   1 
ATOM   3423 C CA  . SER B 1 204 ? 39.66318  9.79457   17.33954  1.000 25.49430 ? 204 SER B CA  1 
ATOM   3424 C C   . SER B 1 204 ? 39.42253  10.40129  15.96420  1.000 17.61868 ? 204 SER B C   1 
ATOM   3425 O O   . SER B 1 204 ? 40.37493  10.72561  15.24941  1.000 22.67067 ? 204 SER B O   1 
ATOM   3426 C CB  . SER B 1 204 ? 40.55299  10.69549  18.19358  1.000 23.67105 ? 204 SER B CB  1 
ATOM   3427 O OG  . SER B 1 204 ? 40.86164  10.06862  19.42713  1.000 24.99465 ? 204 SER B OG  1 
ATOM   3428 N N   . ASP B 1 205 ? 38.15200  10.56874  15.60061  1.000 17.04571 ? 205 ASP B N   1 
ATOM   3429 C CA  . ASP B 1 205 ? 37.79719  10.80634  14.20871  1.000 19.82565 ? 205 ASP B CA  1 
ATOM   3430 C C   . ASP B 1 205 ? 38.03072  12.23963  13.75341  1.000 26.63755 ? 205 ASP B C   1 
ATOM   3431 O O   . ASP B 1 205 ? 38.19464  12.46573  12.54950  1.000 20.87564 ? 205 ASP B O   1 
ATOM   3432 C CB  . ASP B 1 205 ? 36.33866  10.43241  13.96946  1.000 18.55755 ? 205 ASP B CB  1 
ATOM   3433 C CG  . ASP B 1 205 ? 36.01616  10.29831  12.50383  1.000 22.97032 ? 205 ASP B CG  1 
ATOM   3434 O OD1 . ASP B 1 205 ? 36.69178  9.49923   11.81342  1.000 19.39938 ? 205 ASP B OD1 1 
ATOM   3435 O OD2 . ASP B 1 205 ? 35.09698  10.99792  12.04211  1.000 23.67405 ? 205 ASP B OD2 1 
ATOM   3436 N N   . GLY B 1 206 ? 38.01635  13.21082  14.66431  1.000 25.64706 ? 206 GLY B N   1 
ATOM   3437 C CA  . GLY B 1 206 ? 38.43134  14.54961  14.29692  1.000 25.92511 ? 206 GLY B CA  1 
ATOM   3438 C C   . GLY B 1 206 ? 39.92901  14.75289  14.26198  1.000 30.51189 ? 206 GLY B C   1 
ATOM   3439 O O   . GLY B 1 206 ? 40.40397  15.83619  13.90782  1.000 41.16988 ? 206 GLY B O   1 
ATOM   3440 N N   . GLN B 1 207 ? 40.69317  13.71500  14.59308  1.000 23.64326 ? 207 GLN B N   1 
ATOM   3441 C CA  . GLN B 1 207 ? 42.12622  13.81493  14.80808  1.000 24.72543 ? 207 GLN B CA  1 
ATOM   3442 C C   . GLN B 1 207 ? 42.96900  13.17270  13.71155  1.000 35.37884 ? 207 GLN B C   1 
ATOM   3443 O O   . GLN B 1 207 ? 44.06631  13.65818  13.43430  1.000 30.08625 ? 207 GLN B O   1 
ATOM   3444 C CB  . GLN B 1 207 ? 42.47441  13.17957  16.15419  1.000 25.74039 ? 207 GLN B CB  1 
ATOM   3445 C CG  . GLN B 1 207 ? 43.89989  13.31714  16.59161  1.000 36.86420 ? 207 GLN B CG  1 
ATOM   3446 C CD  . GLN B 1 207 ? 44.00787  13.19994  18.09000  1.000 38.24742 ? 207 GLN B CD  1 
ATOM   3447 O OE1 . GLN B 1 207 ? 43.00502  13.31653  18.79798  1.000 33.66627 ? 207 GLN B OE1 1 
ATOM   3448 N NE2 . GLN B 1 207 ? 45.22298  12.97099  18.58844  1.000 46.08112 ? 207 GLN B NE2 1 
ATOM   3449 N N   . ILE B 1 208 ? 42.50072  12.09408  13.08564  1.000 26.03428 ? 208 ILE B N   1 
ATOM   3450 C CA  . ILE B 1 208 ? 43.21301  11.45314  11.99031  1.000 21.85915 ? 208 ILE B CA  1 
ATOM   3451 C C   . ILE B 1 208 ? 42.24848  11.29684  10.82985  1.000 24.30874 ? 208 ILE B C   1 
ATOM   3452 O O   . ILE B 1 208 ? 41.04704  11.53814  10.94983  1.000 24.67442 ? 208 ILE B O   1 
ATOM   3453 C CB  . ILE B 1 208 ? 43.78241  10.06697  12.35892  1.000 22.77005 ? 208 ILE B CB  1 
ATOM   3454 C CG1 . ILE B 1 208 ? 42.62711  9.09489   12.65460  1.000 21.13434 ? 208 ILE B CG1 1 
ATOM   3455 C CG2 . ILE B 1 208 ? 44.74553  10.15191  13.51343  1.000 27.34662 ? 208 ILE B CG2 1 
ATOM   3456 C CD1 . ILE B 1 208 ? 43.03534  7.65824   12.80032  1.000 21.98000 ? 208 ILE B CD1 1 
ATOM   3457 N N   . LEU B 1 209 ? 42.79925  10.87961  9.69818   1.000 25.05036 ? 209 LEU B N   1 
ATOM   3458 C CA  . LEU B 1 209 ? 42.02782  10.26031  8.63532   1.000 26.04364 ? 209 LEU B CA  1 
ATOM   3459 C C   . LEU B 1 209 ? 42.39666  8.78510   8.56650   1.000 20.01993 ? 209 LEU B C   1 
ATOM   3460 O O   . LEU B 1 209 ? 43.43108  8.34799   9.08669   1.000 25.83478 ? 209 LEU B O   1 
ATOM   3461 C CB  . LEU B 1 209 ? 42.27244  10.95635  7.29408   1.000 21.89827 ? 209 LEU B CB  1 
ATOM   3462 C CG  . LEU B 1 209 ? 41.92661  12.44981  7.32870   1.000 31.04040 ? 209 LEU B CG  1 
ATOM   3463 C CD1 . LEU B 1 209 ? 42.53724  13.17897  6.13346   1.000 34.00442 ? 209 LEU B CD1 1 
ATOM   3464 C CD2 . LEU B 1 209 ? 40.41145  12.65838  7.36748   1.000 27.16731 ? 209 LEU B CD2 1 
ATOM   3465 N N   . HIS B 1 210 ? 41.52598  8.00032   7.95343   1.000 14.74020 ? 210 HIS B N   1 
ATOM   3466 C CA  . HIS B 1 210 ? 41.77896  6.57157   7.92649   1.000 21.48049 ? 210 HIS B CA  1 
ATOM   3467 C C   . HIS B 1 210 ? 41.21237  5.98965   6.64401   1.000 23.13977 ? 210 HIS B C   1 
ATOM   3468 O O   . HIS B 1 210 ? 40.43563  6.63239   5.93751   1.000 22.52876 ? 210 HIS B O   1 
ATOM   3469 C CB  . HIS B 1 210 ? 41.18645  5.87396   9.16216   1.000 21.45208 ? 210 HIS B CB  1 
ATOM   3470 C CG  . HIS B 1 210 ? 39.68964  5.84478   9.17643   1.000 26.34685 ? 210 HIS B CG  1 
ATOM   3471 N ND1 . HIS B 1 210 ? 38.96671  4.71197   8.86236   1.000 30.54090 ? 210 HIS B ND1 1 
ATOM   3472 C CD2 . HIS B 1 210 ? 38.77823  6.80914   9.44758   1.000 22.00939 ? 210 HIS B CD2 1 
ATOM   3473 C CE1 . HIS B 1 210 ? 37.67497  4.97764   8.94375   1.000 17.83148 ? 210 HIS B CE1 1 
ATOM   3474 N NE2 . HIS B 1 210 ? 37.53355  6.24268   9.29548   1.000 25.41569 ? 210 HIS B NE2 1 
ATOM   3475 N N   . ALA B 1 211 ? 41.62686  4.76035   6.35436   1.000 20.67406 ? 211 ALA B N   1 
ATOM   3476 C CA  . ALA B 1 211 ? 41.18404  4.03370   5.17731   1.000 22.88564 ? 211 ALA B CA  1 
ATOM   3477 C C   . ALA B 1 211 ? 41.48227  2.56362   5.40157   1.000 19.36733 ? 211 ALA B C   1 
ATOM   3478 O O   . ALA B 1 211 ? 42.18421  2.19304   6.34531   1.000 22.47759 ? 211 ALA B O   1 
ATOM   3479 C CB  . ALA B 1 211 ? 41.87728  4.53600   3.90471   1.000 28.61348 ? 211 ALA B CB  1 
ATOM   3480 N N   . VAL B 1 212 ? 40.93757  1.72900   4.52602   1.000 17.40212 ? 212 VAL B N   1 
ATOM   3481 C CA  . VAL B 1 212 ? 41.23927  0.30403   4.51521   1.000 24.89024 ? 212 VAL B CA  1 
ATOM   3482 C C   . VAL B 1 212 ? 41.48873  -0.11859  3.07237   1.000 23.05496 ? 212 VAL B C   1 
ATOM   3483 O O   . VAL B 1 212 ? 40.80011  0.32790   2.14654   1.000 20.98094 ? 212 VAL B O   1 
ATOM   3484 C CB  . VAL B 1 212 ? 40.10890  -0.53545  5.15705   1.000 22.63636 ? 212 VAL B CB  1 
ATOM   3485 C CG1 . VAL B 1 212 ? 38.82351  -0.40633  4.36650   1.000 27.54927 ? 212 VAL B CG1 1 
ATOM   3486 C CG2 . VAL B 1 212 ? 40.51696  -1.98340  5.27810   1.000 18.88245 ? 212 VAL B CG2 1 
ATOM   3487 N N   . ARG B 1 213 ? 42.46948  -0.96691  2.88378   1.000 19.83072 ? 213 ARG B N   1 
ATOM   3488 C CA  . ARG B 1 213 ? 42.80818  -1.38381  1.54029   1.000 25.86566 ? 213 ARG B CA  1 
ATOM   3489 C C   . ARG B 1 213 ? 41.87957  -2.49969  1.08375   1.000 25.75903 ? 213 ARG B C   1 
ATOM   3490 O O   . ARG B 1 213 ? 41.26982  -3.19028  1.90714   1.000 22.18364 ? 213 ARG B O   1 
ATOM   3491 C CB  . ARG B 1 213 ? 44.27021  -1.82571  1.48957   1.000 21.27689 ? 213 ARG B CB  1 
ATOM   3492 C CG  . ARG B 1 213 ? 45.23208  -0.65476  1.60432   1.000 20.97578 ? 213 ARG B CG  1 
ATOM   3493 C CD  . ARG B 1 213 ? 46.67244  -1.08805  1.44721   1.000 32.31398 ? 213 ARG B CD  1 
ATOM   3494 N NE  . ARG B 1 213 ? 46.87694  -1.96101  0.29327   1.000 28.64620 ? 213 ARG B NE  1 
ATOM   3495 C CZ  . ARG B 1 213 ? 47.03123  -1.53412  -0.95074  1.000 30.68718 ? 213 ARG B CZ  1 
ATOM   3496 N NH1 . ARG B 1 213 ? 46.97990  -0.24648  -1.25230  1.000 38.37171 ? 213 ARG B NH1 1 
ATOM   3497 N NH2 . ARG B 1 213 ? 47.23863  -2.42139  -1.91828  1.000 32.08419 ? 213 ARG B NH2 1 
ATOM   3498 N N   . PRO B 1 214 ? 41.73530  -2.67844  -0.23243  1.000 24.64556 ? 214 PRO B N   1 
ATOM   3499 C CA  . PRO B 1 214 ? 40.93474  -3.79488  -0.74861  1.000 19.17657 ? 214 PRO B CA  1 
ATOM   3500 C C   . PRO B 1 214 ? 41.43265  -5.13671  -0.23925  1.000 19.35839 ? 214 PRO B C   1 
ATOM   3501 O O   . PRO B 1 214 ? 42.59793  -5.29545  0.12779   1.000 22.59888 ? 214 PRO B O   1 
ATOM   3502 C CB  . PRO B 1 214 ? 41.12157  -3.69143  -2.26732  1.000 28.40030 ? 214 PRO B CB  1 
ATOM   3503 C CG  . PRO B 1 214 ? 41.51876  -2.27613  -2.51400  1.000 29.46993 ? 214 PRO B CG  1 
ATOM   3504 C CD  . PRO B 1 214 ? 42.27078  -1.82417  -1.31239  1.000 23.74287 ? 214 PRO B CD  1 
ATOM   3505 N N   . ILE B 1 215 ? 40.53289  -6.11432  -0.22197  1.000 23.44659 ? 215 ILE B N   1 
ATOM   3506 C CA  . ILE B 1 215 ? 40.94089  -7.49951  -0.01815  1.000 27.70441 ? 215 ILE B CA  1 
ATOM   3507 C C   . ILE B 1 215 ? 40.84298  -8.22255  -1.35493  1.000 37.99594 ? 215 ILE B C   1 
ATOM   3508 O O   . ILE B 1 215 ? 40.06982  -7.82948  -2.23885  1.000 29.17098 ? 215 ILE B O   1 
ATOM   3509 C CB  . ILE B 1 215 ? 40.09940  -8.23505  1.04554   1.000 24.90917 ? 215 ILE B CB  1 
ATOM   3510 C CG1 . ILE B 1 215 ? 38.61476  -8.19253  0.66329   1.000 21.63789 ? 215 ILE B CG1 1 
ATOM   3511 C CG2 . ILE B 1 215 ? 40.33012  -7.63598  2.43476   1.000 24.76812 ? 215 ILE B CG2 1 
ATOM   3512 C CD1 . ILE B 1 215 ? 37.73270  -9.09923  1.49441   1.000 23.52292 ? 215 ILE B CD1 1 
ATOM   3513 N N   . HIS B 1 216 ? 41.62211  -9.29147  -1.50363  1.000 27.41144 ? 216 HIS B N   1 
ATOM   3514 C CA  . HIS B 1 216 ? 41.52194  -10.12384 -2.68958  1.000 34.42457 ? 216 HIS B CA  1 
ATOM   3515 C C   . HIS B 1 216 ? 41.75870  -11.56896 -2.29885  1.000 29.44684 ? 216 HIS B C   1 
ATOM   3516 O O   . HIS B 1 216 ? 42.40269  -11.83732 -1.26764  1.000 26.62796 ? 216 HIS B O   1 
ATOM   3517 C CB  . HIS B 1 216 ? 42.49913  -9.68258  -3.79142  1.000 28.58698 ? 216 HIS B CB  1 
ATOM   3518 C CG  . HIS B 1 216 ? 43.77247  -9.10000  -3.27412  1.000 37.74193 ? 216 HIS B CG  1 
ATOM   3519 N ND1 . HIS B 1 216 ? 44.77819  -9.87031  -2.73143  1.000 56.30597 ? 216 HIS B ND1 1 
ATOM   3520 C CD2 . HIS B 1 216 ? 44.20779  -7.81861  -3.22329  1.000 38.14502 ? 216 HIS B CD2 1 
ATOM   3521 C CE1 . HIS B 1 216 ? 45.77965  -9.08815  -2.36564  1.000 52.09523 ? 216 HIS B CE1 1 
ATOM   3522 N NE2 . HIS B 1 216 ? 45.45678  -7.83882  -2.64956  1.000 54.17389 ? 216 HIS B NE2 1 
ATOM   3523 N N   . PRO B 1 217 ? 41.24797  -12.52995 -3.06547  1.000 34.66207 ? 217 PRO B N   1 
ATOM   3524 C CA  . PRO B 1 217 ? 41.31564  -13.93106 -2.64104  1.000 28.25538 ? 217 PRO B CA  1 
ATOM   3525 C C   . PRO B 1 217 ? 42.74162  -14.45612 -2.62728  1.000 35.87612 ? 217 PRO B C   1 
ATOM   3526 O O   . PRO B 1 217 ? 43.55239  -14.13637 -3.50049  1.000 46.62397 ? 217 PRO B O   1 
ATOM   3527 C CB  . PRO B 1 217 ? 40.45784  -14.66646 -3.67822  1.000 40.62669 ? 217 PRO B CB  1 
ATOM   3528 C CG  . PRO B 1 217 ? 40.42877  -13.75556 -4.87147  1.000 40.03864 ? 217 PRO B CG  1 
ATOM   3529 C CD  . PRO B 1 217 ? 40.44608  -12.36812 -4.29679  1.000 28.24748 ? 217 PRO B CD  1 
ATOM   3530 N N   . VAL B 1 218 ? 43.04349  -15.25956 -1.60838  1.000 29.60242 ? 218 VAL B N   1 
ATOM   3531 C CA  . VAL B 1 218 ? 44.30308  -15.99004 -1.53636  1.000 32.56684 ? 218 VAL B CA  1 
ATOM   3532 C C   . VAL B 1 218 ? 44.23080  -17.15473 -2.51752  1.000 31.37093 ? 218 VAL B C   1 
ATOM   3533 O O   . VAL B 1 218 ? 44.91113  -17.16138 -3.55006  1.000 41.98560 ? 218 VAL B O   1 
ATOM   3534 C CB  . VAL B 1 218 ? 44.57942  -16.47714 -0.10204  1.000 35.55350 ? 218 VAL B CB  1 
ATOM   3535 C CG1 . VAL B 1 218 ? 45.79585  -17.40459 -0.06987  1.000 37.88474 ? 218 VAL B CG1 1 
ATOM   3536 C CG2 . VAL B 1 218 ? 44.77519  -15.29024 0.82620   1.000 33.69608 ? 218 VAL B CG2 1 
ATOM   3537 N N   . ASP B 1 219 ? 43.40636  -18.14213 -2.19320  1.000 29.98572 ? 219 ASP B N   1 
ATOM   3538 C CA  . ASP B 1 219 ? 42.98936  -19.19774 -3.10153  1.000 36.91732 ? 219 ASP B CA  1 
ATOM   3539 C C   . ASP B 1 219 ? 42.08027  -18.56350 -4.14662  1.000 43.47999 ? 219 ASP B C   1 
ATOM   3540 O O   . ASP B 1 219 ? 40.90432  -18.29256 -3.86869  1.000 36.48035 ? 219 ASP B O   1 
ATOM   3541 C CB  . ASP B 1 219 ? 42.28148  -20.31021 -2.32090  1.000 39.10729 ? 219 ASP B CB  1 
ATOM   3542 C CG  . ASP B 1 219 ? 41.70533  -21.40826 -3.21444  1.000 44.02952 ? 219 ASP B CG  1 
ATOM   3543 O OD1 . ASP B 1 219 ? 41.81190  -21.33138 -4.45806  1.000 43.68195 ? 219 ASP B OD1 1 
ATOM   3544 O OD2 . ASP B 1 219 ? 41.13080  -22.36180 -2.64903  1.000 40.55580 ? 219 ASP B OD2 1 
ATOM   3545 N N   . PRO B 1 220 ? 42.57465  -18.33329 -5.36093  1.000 46.08303 ? 220 PRO B N   1 
ATOM   3546 C CA  . PRO B 1 220 ? 41.82411  -17.50570 -6.31185  1.000 47.89017 ? 220 PRO B CA  1 
ATOM   3547 C C   . PRO B 1 220 ? 40.52888  -18.14895 -6.77512  1.000 39.40050 ? 220 PRO B C   1 
ATOM   3548 O O   . PRO B 1 220 ? 39.77477  -17.53552 -7.53415  1.000 56.62098 ? 220 PRO B O   1 
ATOM   3549 C CB  . PRO B 1 220 ? 42.81353  -17.32495 -7.46886  1.000 45.50968 ? 220 PRO B CB  1 
ATOM   3550 C CG  . PRO B 1 220 ? 43.65829  -18.54750 -7.41634  1.000 50.46432 ? 220 PRO B CG  1 
ATOM   3551 C CD  . PRO B 1 220 ? 43.80376  -18.88607 -5.95802  1.000 53.06912 ? 220 PRO B CD  1 
ATOM   3552 N N   . THR B 1 221 ? 40.24623  -19.36457 -6.31258  1.000 39.53805 ? 221 THR B N   1 
ATOM   3553 C CA  . THR B 1 221 ? 39.00780  -20.05407 -6.64963  1.000 47.49455 ? 221 THR B CA  1 
ATOM   3554 C C   . THR B 1 221 ? 37.94629  -19.95089 -5.56206  1.000 52.62329 ? 221 THR B C   1 
ATOM   3555 O O   . THR B 1 221 ? 36.88731  -20.57877 -5.68988  1.000 48.11319 ? 221 THR B O   1 
ATOM   3556 C CB  . THR B 1 221 ? 39.27646  -21.53510 -6.94595  1.000 51.19286 ? 221 THR B CB  1 
ATOM   3557 O OG1 . THR B 1 221 ? 39.91567  -22.14213 -5.81443  1.000 51.86629 ? 221 THR B OG1 1 
ATOM   3558 C CG2 . THR B 1 221 ? 40.14957  -21.69138 -8.18118  1.000 48.39972 ? 221 THR B CG2 1 
ATOM   3559 N N   . LYS B 1 222 ? 38.20035  -19.19924 -4.49277  1.000 42.71972 ? 222 LYS B N   1 
ATOM   3560 C CA  . LYS B 1 222 ? 37.20965  -18.99683 -3.44570  1.000 46.41456 ? 222 LYS B CA  1 
ATOM   3561 C C   . LYS B 1 222 ? 37.04737  -17.50646 -3.19306  1.000 31.28490 ? 222 LYS B C   1 
ATOM   3562 O O   . LYS B 1 222 ? 37.89321  -16.69468 -3.56853  1.000 38.10303 ? 222 LYS B O   1 
ATOM   3563 C CB  . LYS B 1 222 ? 37.58514  -19.72247 -2.14392  1.000 39.79978 ? 222 LYS B CB  1 
ATOM   3564 C CG  . LYS B 1 222 ? 37.31417  -21.21881 -2.18159  1.000 31.72704 ? 222 LYS B CG  1 
ATOM   3565 C CD  . LYS B 1 222 ? 37.13732  -21.79116 -0.78099  1.000 45.33227 ? 222 LYS B CD  1 
ATOM   3566 C CE  . LYS B 1 222 ? 38.45754  -21.89000 -0.03732  1.000 44.62305 ? 222 LYS B CE  1 
ATOM   3567 N NZ  . LYS B 1 222 ? 39.30503  -22.99690 -0.56921  1.000 54.95159 ? 222 LYS B NZ  1 
ATOM   3568 N N   . ALA B 1 223 ? 35.92894  -17.14946 -2.58089  1.000 28.09910 ? 223 ALA B N   1 
ATOM   3569 C CA  . ALA B 1 223 ? 35.70694  -15.75810 -2.24181  1.000 36.51197 ? 223 ALA B CA  1 
ATOM   3570 C C   . ALA B 1 223 ? 36.62802  -15.34362 -1.09667  1.000 27.63545 ? 223 ALA B C   1 
ATOM   3571 O O   . ALA B 1 223 ? 36.93708  -16.13219 -0.20023  1.000 29.04227 ? 223 ALA B O   1 
ATOM   3572 C CB  . ALA B 1 223 ? 34.24162  -15.53428 -1.86255  1.000 29.78491 ? 223 ALA B CB  1 
ATOM   3573 N N   . ALA B 1 224 ? 37.08918  -14.10067 -1.14563  1.000 29.79463 ? 224 ALA B N   1 
ATOM   3574 C CA  . ALA B 1 224 ? 37.69399  -13.47437 0.02508   1.000 38.16904 ? 224 ALA B CA  1 
ATOM   3575 C C   . ALA B 1 224 ? 36.61274  -12.71487 0.78621   1.000 27.81318 ? 224 ALA B C   1 
ATOM   3576 O O   . ALA B 1 224 ? 35.87311  -11.92500 0.18930   1.000 23.49210 ? 224 ALA B O   1 
ATOM   3577 C CB  . ALA B 1 224 ? 38.82368  -12.52627 -0.37456  1.000 30.76548 ? 224 ALA B CB  1 
ATOM   3578 N N   . VAL B 1 225 ? 36.52380  -12.95805 2.09672   1.000 24.02687 ? 225 VAL B N   1 
ATOM   3579 C CA  . VAL B 1 225 ? 35.50762  -12.35373 2.95513   1.000 21.45074 ? 225 VAL B CA  1 
ATOM   3580 C C   . VAL B 1 225 ? 36.18225  -11.70321 4.16145   1.000 27.71060 ? 225 VAL B C   1 
ATOM   3581 O O   . VAL B 1 225 ? 37.06795  -12.30350 4.77883   1.000 18.22086 ? 225 VAL B O   1 
ATOM   3582 C CB  . VAL B 1 225 ? 34.46912  -13.39024 3.42113   1.000 23.58414 ? 225 VAL B CB  1 
ATOM   3583 C CG1 . VAL B 1 225 ? 33.42168  -12.72490 4.30349   1.000 21.80527 ? 225 VAL B CG1 1 
ATOM   3584 C CG2 . VAL B 1 225 ? 33.80982  -14.05970 2.22078   1.000 31.94266 ? 225 VAL B CG2 1 
ATOM   3585 N N   . ARG B 1 226 ? 35.77212  -10.47103 4.48199   1.000 22.94371 ? 226 ARG B N   1 
ATOM   3586 C CA  . ARG B 1 226 ? 36.23242  -9.73764  5.66440   1.000 23.54109 ? 226 ARG B CA  1 
ATOM   3587 C C   . ARG B 1 226 ? 35.00448  -9.18544  6.37465   1.000 16.66489 ? 226 ARG B C   1 
ATOM   3588 O O   . ARG B 1 226 ? 34.21397  -8.45402  5.77073   1.000 25.05483 ? 226 ARG B O   1 
ATOM   3589 C CB  . ARG B 1 226 ? 37.19414  -8.60137  5.28243   1.000 24.17307 ? 226 ARG B CB  1 
ATOM   3590 C CG  . ARG B 1 226 ? 37.91751  -7.90798  6.47190   1.000 23.18157 ? 226 ARG B CG  1 
ATOM   3591 C CD  . ARG B 1 226 ? 38.87726  -6.83331  5.95444   1.000 29.71530 ? 226 ARG B CD  1 
ATOM   3592 N NE  . ARG B 1 226 ? 39.53628  -6.06105  7.00516   1.000 26.17331 ? 226 ARG B NE  1 
ATOM   3593 C CZ  . ARG B 1 226 ? 39.08514  -4.90574  7.47862   1.000 31.52950 ? 226 ARG B CZ  1 
ATOM   3594 N NH1 . ARG B 1 226 ? 37.94588  -4.38037  7.04944   1.000 29.91077 ? 226 ARG B NH1 1 
ATOM   3595 N NH2 . ARG B 1 226 ? 39.79181  -4.26074  8.40839   1.000 23.87525 ? 226 ARG B NH2 1 
ATOM   3596 N N   . ASP B 1 227 ? 34.82759  -9.55150  7.63754   1.000 20.79560 ? 227 ASP B N   1 
ATOM   3597 C CA  . ASP B 1 227 ? 33.64249  -9.19684  8.40943   1.000 14.75659 ? 227 ASP B CA  1 
ATOM   3598 C C   . ASP B 1 227 ? 34.02200  -8.27847  9.55919   1.000 16.68270 ? 227 ASP B C   1 
ATOM   3599 O O   . ASP B 1 227 ? 34.95610  -8.56555  10.30887  1.000 14.12364 ? 227 ASP B O   1 
ATOM   3600 C CB  . ASP B 1 227 ? 32.96341  -10.43599 8.97385   1.000 17.30877 ? 227 ASP B CB  1 
ATOM   3601 C CG  . ASP B 1 227 ? 32.28064  -11.25129 7.91632   1.000 21.65659 ? 227 ASP B CG  1 
ATOM   3602 O OD1 . ASP B 1 227 ? 31.98007  -10.69290 6.84083   1.000 23.25988 ? 227 ASP B OD1 1 
ATOM   3603 O OD2 . ASP B 1 227 ? 32.02699  -12.44177 8.17389   1.000 18.71571 ? 227 ASP B OD2 1 
ATOM   3604 N N   . VAL B 1 228 ? 33.25293  -7.21480  9.74495   1.000 16.26439 ? 228 VAL B N   1 
ATOM   3605 C CA  . VAL B 1 228 ? 33.70975  -6.14382  10.61521  1.000 22.09805 ? 228 VAL B CA  1 
ATOM   3606 C C   . VAL B 1 228 ? 32.51315  -5.51817  11.33417  1.000 17.98854 ? 228 VAL B C   1 
ATOM   3607 O O   . VAL B 1 228 ? 31.42773  -5.37464  10.76056  1.000 14.26768 ? 228 VAL B O   1 
ATOM   3608 C CB  . VAL B 1 228 ? 34.53466  -5.17928  9.73838   1.000 19.56906 ? 228 VAL B CB  1 
ATOM   3609 C CG1 . VAL B 1 228 ? 33.98382  -3.78968  9.70991   1.000 22.08875 ? 228 VAL B CG1 1 
ATOM   3610 C CG2 . VAL B 1 228 ? 36.02407  -5.25263  10.07876  1.000 20.96243 ? 228 VAL B CG2 1 
ATOM   3611 N N   . LEU B 1 229 ? 32.69478  -5.22016  12.62357  1.000 11.39651 ? 229 LEU B N   1 
ATOM   3612 C CA  . LEU B 1 229 ? 31.71461  -4.48919  13.42431  1.000 12.77148 ? 229 LEU B CA  1 
ATOM   3613 C C   . LEU B 1 229 ? 32.26219  -3.09616  13.69030  1.000 13.88001 ? 229 LEU B C   1 
ATOM   3614 O O   . LEU B 1 229 ? 33.33218  -2.95848  14.29871  1.000 12.82674 ? 229 LEU B O   1 
ATOM   3615 C CB  . LEU B 1 229 ? 31.42557  -5.20703  14.75205  1.000 11.82322 ? 229 LEU B CB  1 
ATOM   3616 C CG  . LEU B 1 229 ? 30.48878  -4.48249  15.72742  1.000 12.13297 ? 229 LEU B CG  1 
ATOM   3617 C CD1 . LEU B 1 229 ? 29.06813  -4.34390  15.16010  1.000 8.68001  ? 229 LEU B CD1 1 
ATOM   3618 C CD2 . LEU B 1 229 ? 30.46950  -5.22371  17.07622  1.000 10.38086 ? 229 LEU B CD2 1 
ATOM   3619 N N   . ILE B 1 230 ? 31.54625  -2.06939  13.22804  1.000 9.36285  ? 230 ILE B N   1 
ATOM   3620 C CA  . ILE B 1 230 ? 31.98288  -0.68189  13.35680  1.000 12.54929 ? 230 ILE B CA  1 
ATOM   3621 C C   . ILE B 1 230 ? 30.97361  0.09396   14.19209  1.000 15.20058 ? 230 ILE B C   1 
ATOM   3622 O O   . ILE B 1 230 ? 29.76289  0.02528   13.94133  1.000 12.10409 ? 230 ILE B O   1 
ATOM   3623 C CB  . ILE B 1 230 ? 32.15959  -0.00290  11.99188  1.000 15.06747 ? 230 ILE B CB  1 
ATOM   3624 C CG1 . ILE B 1 230 ? 33.04305  -0.85102  11.08813  1.000 17.04658 ? 230 ILE B CG1 1 
ATOM   3625 C CG2 . ILE B 1 230 ? 32.80176  1.36131   12.16121  1.000 17.89450 ? 230 ILE B CG2 1 
ATOM   3626 C CD1 . ILE B 1 230 ? 33.33436  -0.17432  9.74177   1.000 21.87924 ? 230 ILE B CD1 1 
ATOM   3627 N N   . MET B 1 231 ? 31.47199  0.84861   15.16932  1.000 11.45626 ? 231 MET B N   1 
ATOM   3628 C CA  . MET B 1 231 ? 30.61949  1.74184   15.93987  1.000 15.94792 ? 231 MET B CA  1 
ATOM   3629 C C   . MET B 1 231 ? 31.18088  3.15713   15.94710  1.000 10.99730 ? 231 MET B C   1 
ATOM   3630 O O   . MET B 1 231 ? 32.37362  3.36297   16.17464  1.000 14.79612 ? 231 MET B O   1 
ATOM   3631 C CB  . MET B 1 231 ? 30.42948  1.22269   17.36309  1.000 14.20453 ? 231 MET B CB  1 
ATOM   3632 C CG  . MET B 1 231 ? 29.44797  0.07719   17.38875  1.000 15.53920 ? 231 MET B CG  1 
ATOM   3633 S SD  . MET B 1 231 ? 29.07817  -0.52808  19.02968  1.000 19.43721 ? 231 MET B SD  1 
ATOM   3634 C CE  . MET B 1 231 ? 30.69606  -1.05324  19.56177  1.000 16.01827 ? 231 MET B CE  1 
ATOM   3635 N N   . GLY B 1 232 ? 30.32117  4.12758   15.67409  1.000 12.95576 ? 232 GLY B N   1 
ATOM   3636 C CA  . GLY B 1 232 ? 30.75292  5.51084   15.68233  1.000 15.02698 ? 232 GLY B CA  1 
ATOM   3637 C C   . GLY B 1 232 ? 29.98461  6.26352   16.74115  1.000 11.48908 ? 232 GLY B C   1 
ATOM   3638 O O   . GLY B 1 232 ? 28.75361  6.16564   16.80069  1.000 14.27228 ? 232 GLY B O   1 
ATOM   3639 N N   . TYR B 1 233 ? 30.69452  6.98674   17.59820  1.000 12.00476 ? 233 TYR B N   1 
ATOM   3640 C CA  . TYR B 1 233 ? 30.09913  7.68439   18.73558  1.000 14.84167 ? 233 TYR B CA  1 
ATOM   3641 C C   . TYR B 1 233 ? 30.18565  9.18860   18.50258  1.000 15.99281 ? 233 TYR B C   1 
ATOM   3642 O O   . TYR B 1 233 ? 31.27776  9.71984   18.28516  1.000 17.97113 ? 233 TYR B O   1 
ATOM   3643 C CB  . TYR B 1 233 ? 30.81407  7.32419   20.03735  1.000 18.55580 ? 233 TYR B CB  1 
ATOM   3644 C CG  . TYR B 1 233 ? 30.86537  5.85064   20.43089  1.000 13.96165 ? 233 TYR B CG  1 
ATOM   3645 C CD1 . TYR B 1 233 ? 31.61954  4.92507   19.69810  1.000 12.12773 ? 233 TYR B CD1 1 
ATOM   3646 C CD2 . TYR B 1 233 ? 30.22721  5.40206   21.59203  1.000 10.30167 ? 233 TYR B CD2 1 
ATOM   3647 C CE1 . TYR B 1 233 ? 31.70042  3.58388   20.08283  1.000 9.25383  ? 233 TYR B CE1 1 
ATOM   3648 C CE2 . TYR B 1 233 ? 30.29894  4.05734   21.98703  1.000 9.51018  ? 233 TYR B CE2 1 
ATOM   3649 C CZ  . TYR B 1 233 ? 31.04571  3.15243   21.23921  1.000 10.95796 ? 233 TYR B CZ  1 
ATOM   3650 O OH  . TYR B 1 233 ? 31.12344  1.82489   21.65372  1.000 9.89975  ? 233 TYR B OH  1 
ATOM   3651 N N   . LYS B 1 234 ? 29.04514  9.87516   18.57485  1.000 14.66237 ? 234 LYS B N   1 
ATOM   3652 C CA  . LYS B 1 234 ? 28.98711  11.32144  18.39468  1.000 16.06629 ? 234 LYS B CA  1 
ATOM   3653 C C   . LYS B 1 234 ? 28.24489  11.96057  19.56445  1.000 11.34852 ? 234 LYS B C   1 
ATOM   3654 O O   . LYS B 1 234 ? 27.06979  11.66473  19.79071  1.000 17.38595 ? 234 LYS B O   1 
ATOM   3655 C CB  . LYS B 1 234 ? 28.29924  11.68605  17.07643  1.000 20.45393 ? 234 LYS B CB  1 
ATOM   3656 C CG  . LYS B 1 234 ? 28.71744  13.06760  16.59368  1.000 33.05834 ? 234 LYS B CG  1 
ATOM   3657 C CD  . LYS B 1 234 ? 28.07309  13.44732  15.26887  1.000 37.57698 ? 234 LYS B CD  1 
ATOM   3658 C CE  . LYS B 1 234 ? 28.58167  14.80767  14.81332  1.000 36.37961 ? 234 LYS B CE  1 
ATOM   3659 N NZ  . LYS B 1 234 ? 28.53417  15.79433  15.92560  1.000 31.01314 ? 234 LYS B NZ  1 
ATOM   3660 N N   . HIS B 1 235 ? 28.93988  12.80550  20.31401  1.000 14.76744 ? 235 HIS B N   1 
ATOM   3661 C CA  . HIS B 1 235 ? 28.34175  13.56836  21.41351  1.000 18.85511 ? 235 HIS B CA  1 
ATOM   3662 C C   . HIS B 1 235 ? 27.22435  14.45615  20.87931  1.000 19.59824 ? 235 HIS B C   1 
ATOM   3663 O O   . HIS B 1 235 ? 27.45246  15.25425  19.96430  1.000 22.07017 ? 235 HIS B O   1 
ATOM   3664 C CB  . HIS B 1 235 ? 29.43439  14.41299  22.09035  1.000 21.28249 ? 235 HIS B CB  1 
ATOM   3665 C CG  . HIS B 1 235 ? 28.95057  15.27297  23.22527  1.000 31.77085 ? 235 HIS B CG  1 
ATOM   3666 N ND1 . HIS B 1 235 ? 29.26336  16.61520  23.32583  1.000 27.49119 ? 235 HIS B ND1 1 
ATOM   3667 C CD2 . HIS B 1 235 ? 28.20415  14.97866  24.31951  1.000 19.99835 ? 235 HIS B CD2 1 
ATOM   3668 C CE1 . HIS B 1 235 ? 28.71663  17.11294  24.42345  1.000 26.74359 ? 235 HIS B CE1 1 
ATOM   3669 N NE2 . HIS B 1 235 ? 28.06862  16.14182  25.04402  1.000 27.59106 ? 235 HIS B NE2 1 
ATOM   3670 N N   . GLU B 1 236 ? 26.01527  14.29196  21.42728  1.000 16.55271 ? 236 GLU B N   1 
ATOM   3671 C CA  . GLU B 1 236 ? 24.82520  15.03720  20.99659  1.000 24.06247 ? 236 GLU B CA  1 
ATOM   3672 C C   . GLU B 1 236 ? 24.03496  15.50450  22.21482  1.000 20.41776 ? 236 GLU B C   1 
ATOM   3673 O O   . GLU B 1 236 ? 23.05435  14.87546  22.61265  1.000 22.96018 ? 236 GLU B O   1 
ATOM   3674 C CB  . GLU B 1 236 ? 23.91961  14.18382  20.10111  1.000 15.79904 ? 236 GLU B CB  1 
ATOM   3675 C CG  . GLU B 1 236 ? 24.56055  13.68171  18.83284  1.000 27.35457 ? 236 GLU B CG  1 
ATOM   3676 C CD  . GLU B 1 236 ? 24.76901  14.77903  17.79979  1.000 45.27447 ? 236 GLU B CD  1 
ATOM   3677 O OE1 . GLU B 1 236 ? 24.38674  15.94271  18.05615  1.000 32.40279 ? 236 GLU B OE1 1 
ATOM   3678 O OE2 . GLU B 1 236 ? 25.31785  14.47135  16.72356  1.000 38.08133 ? 236 GLU B OE2 1 
ATOM   3679 N N   . PRO B 1 237 ? 24.43229  16.62589  22.81490  1.000 24.38706 ? 237 PRO B N   1 
ATOM   3680 C CA  . PRO B 1 237 ? 23.76609  17.05865  24.06146  1.000 21.13559 ? 237 PRO B CA  1 
ATOM   3681 C C   . PRO B 1 237 ? 22.27015  17.25177  23.92403  1.000 28.16374 ? 237 PRO B C   1 
ATOM   3682 O O   . PRO B 1 237 ? 21.54211  17.11852  24.91676  1.000 34.91174 ? 237 PRO B O   1 
ATOM   3683 C CB  . PRO B 1 237 ? 24.47011  18.38049  24.39484  1.000 29.85852 ? 237 PRO B CB  1 
ATOM   3684 C CG  . PRO B 1 237 ? 25.71518  18.40045  23.56785  1.000 30.13513 ? 237 PRO B CG  1 
ATOM   3685 C CD  . PRO B 1 237 ? 25.46350  17.56798  22.36041  1.000 27.81407 ? 237 PRO B CD  1 
ATOM   3686 N N   . GLU B 1 238 ? 21.77842  17.53866  22.72251  1.000 31.77867 ? 238 GLU B N   1 
ATOM   3687 C CA  . GLU B 1 238 ? 20.37299  17.85929  22.51438  1.000 35.93619 ? 238 GLU B CA  1 
ATOM   3688 C C   . GLU B 1 238 ? 19.56485  16.67996  22.00113  1.000 26.06791 ? 238 GLU B C   1 
ATOM   3689 O O   . GLU B 1 238 ? 18.38301  16.84842  21.69356  1.000 29.97351 ? 238 GLU B O   1 
ATOM   3690 C CB  . GLU B 1 238 ? 20.23993  19.04366  21.54481  1.000 36.11815 ? 238 GLU B CB  1 
ATOM   3691 C CG  . GLU B 1 238 ? 21.32055  20.12114  21.72217  1.000 43.73239 ? 238 GLU B CG  1 
ATOM   3692 C CD  . GLU B 1 238 ? 21.40737  20.65584  23.15021  1.000 49.74672 ? 238 GLU B CD  1 
ATOM   3693 O OE1 . GLU B 1 238 ? 20.34859  20.80401  23.79854  1.000 39.72582 ? 238 GLU B OE1 1 
ATOM   3694 O OE2 . GLU B 1 238 ? 22.53889  20.91834  23.62740  1.000 53.80568 ? 238 GLU B OE2 1 
ATOM   3695 N N   . LEU B 1 239 ? 20.16796  15.49566  21.89179  1.000 31.10189 ? 239 LEU B N   1 
ATOM   3696 C CA  . LEU B 1 239 ? 19.42355  14.31934  21.45230  1.000 27.47740 ? 239 LEU B CA  1 
ATOM   3697 C C   . LEU B 1 239 ? 18.38933  13.92729  22.50418  1.000 20.13400 ? 239 LEU B C   1 
ATOM   3698 O O   . LEU B 1 239 ? 18.69564  13.84845  23.69393  1.000 21.07262 ? 239 LEU B O   1 
ATOM   3699 C CB  . LEU B 1 239 ? 20.37667  13.15527  21.18849  1.000 26.49485 ? 239 LEU B CB  1 
ATOM   3700 C CG  . LEU B 1 239 ? 19.70791  11.82808  20.81096  1.000 22.81545 ? 239 LEU B CG  1 
ATOM   3701 C CD1 . LEU B 1 239 ? 18.90267  11.96805  19.52712  1.000 21.62425 ? 239 LEU B CD1 1 
ATOM   3702 C CD2 . LEU B 1 239 ? 20.73466  10.69740  20.69239  1.000 27.07303 ? 239 LEU B CD2 1 
ATOM   3703 N N   . ARG B 1 240 ? 17.16393  13.67674  22.07262  1.000 20.05718 ? 240 ARG B N   1 
ATOM   3704 C CA  . ARG B 1 240 ? 16.09216  13.33360  22.99020  1.000 22.38903 ? 240 ARG B CA  1 
ATOM   3705 C C   . ARG B 1 240 ? 15.71675  11.87196  22.81120  1.000 27.29557 ? 240 ARG B C   1 
ATOM   3706 O O   . ARG B 1 240 ? 15.98732  11.26915  21.76659  1.000 24.22605 ? 240 ARG B O   1 
ATOM   3707 C CB  . ARG B 1 240 ? 14.86648  14.22978  22.76357  1.000 31.16791 ? 240 ARG B CB  1 
ATOM   3708 C CG  . ARG B 1 240 ? 15.08081  15.68187  23.16695  1.000 34.69286 ? 240 ARG B CG  1 
ATOM   3709 C CD  . ARG B 1 240 ? 14.67260  15.94590  24.62791  1.000 45.61861 ? 240 ARG B CD  1 
ATOM   3710 N NE  . ARG B 1 240 ? 13.22577  16.05672  24.79514  1.000 55.33170 ? 240 ARG B NE  1 
ATOM   3711 C CZ  . ARG B 1 240 ? 12.44920  15.12099  25.32930  1.000 51.82374 ? 240 ARG B CZ  1 
ATOM   3712 N NH1 . ARG B 1 240 ? 12.95014  13.99544  25.81376  1.000 48.53146 ? 240 ARG B NH1 1 
ATOM   3713 N NH2 . ARG B 1 240 ? 11.13515  15.31750  25.37621  1.000 52.57183 ? 240 ARG B NH2 1 
ATOM   3714 N N   . ARG B 1 241 ? 15.11207  11.29694  23.84844  1.000 19.09020 ? 241 ARG B N   1 
ATOM   3715 C CA  . ARG B 1 241 ? 14.65224  9.92060   23.75067  1.000 22.38982 ? 241 ARG B CA  1 
ATOM   3716 C C   . ARG B 1 241 ? 13.43712  9.84700   22.84530  1.000 21.72815 ? 241 ARG B C   1 
ATOM   3717 O O   . ARG B 1 241 ? 12.57914  10.73145  22.86188  1.000 28.08858 ? 241 ARG B O   1 
ATOM   3718 C CB  . ARG B 1 241 ? 14.31500  9.35027   25.12876  1.000 16.68439 ? 241 ARG B CB  1 
ATOM   3719 C CG  . ARG B 1 241 ? 15.50616  9.30781   26.05648  1.000 15.17916 ? 241 ARG B CG  1 
ATOM   3720 C CD  . ARG B 1 241 ? 15.13570  8.70123   27.41398  1.000 17.48346 ? 241 ARG B CD  1 
ATOM   3721 N NE  . ARG B 1 241 ? 16.31105  8.70799   28.27124  1.000 21.03365 ? 241 ARG B NE  1 
ATOM   3722 C CZ  . ARG B 1 241 ? 16.71974  9.76742   28.94621  1.000 24.64790 ? 241 ARG B CZ  1 
ATOM   3723 N NH1 . ARG B 1 241 ? 16.00732  10.88228  28.97179  1.000 26.39504 ? 241 ARG B NH1 1 
ATOM   3724 N NH2 . ARG B 1 241 ? 17.87830  9.71529   29.59609  1.000 18.59246 ? 241 ARG B NH2 1 
ATOM   3725 N N   . GLU B 1 242 ? 13.36779  8.77391   22.06493  1.000 26.28752 ? 242 GLU B N   1 
ATOM   3726 C CA  . GLU B 1 242 ? 12.34124  8.57043   21.05278  1.000 27.52647 ? 242 GLU B CA  1 
ATOM   3727 C C   . GLU B 1 242 ? 11.50238  7.36656   21.45558  1.000 35.29383 ? 242 GLU B C   1 
ATOM   3728 O O   . GLU B 1 242 ? 12.04982  6.31498   21.80495  1.000 32.37495 ? 242 GLU B O   1 
ATOM   3729 C CB  . GLU B 1 242 ? 12.99176  8.36389   19.66500  1.000 24.49841 ? 242 GLU B CB  1 
ATOM   3730 C CG  . GLU B 1 242 ? 13.81324  9.58581   19.19923  1.000 26.47595 ? 242 GLU B CG  1 
ATOM   3731 C CD  . GLU B 1 242 ? 14.82581  9.28000   18.08607  1.000 34.77353 ? 242 GLU B CD  1 
ATOM   3732 O OE1 . GLU B 1 242 ? 15.87627  8.65339   18.36253  1.000 24.04994 ? 242 GLU B OE1 1 
ATOM   3733 O OE2 . GLU B 1 242 ? 14.57474  9.68275   16.93069  1.000 33.69828 ? 242 GLU B OE2 1 
ATOM   3734 N N   . GLU B 1 243 ? 10.18200  7.52557   21.43668  1.000 34.87571 ? 243 GLU B N   1 
ATOM   3735 C CA  . GLU B 1 243 ? 9.29019   6.41069   21.73398  1.000 42.52861 ? 243 GLU B CA  1 
ATOM   3736 C C   . GLU B 1 243 ? 8.37478   6.11012   20.54510  1.000 47.02903 ? 243 GLU B C   1 
ATOM   3737 O O   . GLU B 1 243 ? 8.59955   5.15177   19.79790  1.000 54.22605 ? 243 GLU B O   1 
ATOM   3738 C CB  . GLU B 1 243 ? 8.46219   6.69924   22.98404  1.000 38.92669 ? 243 GLU B CB  1 
ATOM   3739 C CG  . GLU B 1 243 ? 7.96771   5.44209   23.68836  1.000 50.14958 ? 243 GLU B CG  1 
ATOM   3740 C CD  . GLU B 1 243 ? 8.75802   5.12575   24.94836  1.000 36.80325 ? 243 GLU B CD  1 
ATOM   3741 O OE1 . GLU B 1 243 ? 9.71696   5.87028   25.26425  1.000 39.19544 ? 243 GLU B OE1 1 
ATOM   3742 O OE2 . GLU B 1 243 ? 8.41200   4.13479   25.63406  1.000 57.32245 ? 243 GLU B OE2 1 
HETATM 3743 K K   . K   C 2 .   ? 19.59276  10.31409  56.33733  1.000 37.73086 ? 301 K   A K   1 
HETATM 3744 S S   . SCN D 3 .   ? 35.67708  -0.90525  7.19967   1.000 55.13813 ? 301 SCN B S   1 
HETATM 3745 C C   . SCN D 3 .   ? 37.01026  -1.47216  7.98315   1.000 25.67390 ? 301 SCN B C   1 
HETATM 3746 N N   . SCN D 3 .   ? 37.96241  -1.88244  8.51273   1.000 32.74842 ? 301 SCN B N   1 
HETATM 3747 S S   . SCN E 3 .   ? 33.07962  -18.05305 2.62957   1.000 69.84400 ? 302 SCN B S   1 
HETATM 3748 C C   . SCN E 3 .   ? 32.06756  -17.62006 3.85416   1.000 46.72299 ? 302 SCN B C   1 
HETATM 3749 N N   . SCN E 3 .   ? 31.34889  -17.32071 4.72050   1.000 48.95277 ? 302 SCN B N   1 
HETATM 3750 K K   . K   F 2 .   ? 38.28691  -5.31019  -0.78505  1.000 56.85869 ? 303 K   B K   1 
HETATM 3751 C C1  . GOL G 4 .   ? 15.09375  -5.37290  14.80120  1.000 40.44968 ? 304 GOL B C1  1 
HETATM 3752 O O1  . GOL G 4 .   ? 15.96028  -5.82685  13.78041  1.000 45.49284 ? 304 GOL B O1  1 
HETATM 3753 C C2  . GOL G 4 .   ? 14.80707  -3.88295  14.70554  1.000 34.08106 ? 304 GOL B C2  1 
HETATM 3754 O O2  . GOL G 4 .   ? 14.11685  -3.52402  15.87903  1.000 45.64040 ? 304 GOL B O2  1 
HETATM 3755 C C3  . GOL G 4 .   ? 16.07854  -3.05918  14.54452  1.000 33.22262 ? 304 GOL B C3  1 
HETATM 3756 O O3  . GOL G 4 .   ? 15.77875  -1.68468  14.31883  1.000 22.26578 ? 304 GOL B O3  1 
HETATM 3757 O O   . HOH H 5 .   ? 17.57962  -14.89380 52.73117  1.000 29.66498 ? 401 HOH A O   1 
HETATM 3758 O O   . HOH H 5 .   ? 1.51739   6.93853   62.25777  1.000 20.28621 ? 402 HOH A O   1 
HETATM 3759 O O   . HOH H 5 .   ? 11.35547  -7.75206  39.65019  1.000 36.37082 ? 403 HOH A O   1 
HETATM 3760 O O   . HOH H 5 .   ? -1.23080  9.91266   57.93148  1.000 31.88271 ? 404 HOH A O   1 
HETATM 3761 O O   . HOH H 5 .   ? 22.76831  12.71338  35.90805  1.000 34.59720 ? 405 HOH A O   1 
HETATM 3762 O O   . HOH H 5 .   ? -5.80585  9.04811   61.01405  1.000 44.03047 ? 406 HOH A O   1 
HETATM 3763 O O   . HOH H 5 .   ? 37.31104  -17.46659 45.86022  1.000 42.95069 ? 407 HOH A O   1 
HETATM 3764 O O   . HOH H 5 .   ? 19.30128  -14.22403 59.76914  1.000 40.62892 ? 408 HOH A O   1 
HETATM 3765 O O   . HOH H 5 .   ? 12.94613  13.20272  45.97254  1.000 36.26690 ? 409 HOH A O   1 
HETATM 3766 O O   . HOH H 5 .   ? 30.20607  -1.80423  39.49964  1.000 31.92424 ? 410 HOH A O   1 
HETATM 3767 O O   . HOH H 5 .   ? 20.04469  12.45986  60.18218  1.000 39.09460 ? 411 HOH A O   1 
HETATM 3768 O O   . HOH H 5 .   ? 26.33596  -11.71579 58.77839  1.000 36.48849 ? 412 HOH A O   1 
HETATM 3769 O O   . HOH H 5 .   ? 14.43021  -11.04722 35.36848  1.000 31.46004 ? 413 HOH A O   1 
HETATM 3770 O O   . HOH H 5 .   ? 27.96328  11.83746  43.82644  1.000 43.40999 ? 414 HOH A O   1 
HETATM 3771 O O   . HOH H 5 .   ? 10.76550  16.68280  46.51542  1.000 36.32528 ? 415 HOH A O   1 
HETATM 3772 O O   . HOH H 5 .   ? 6.19660   -14.83928 53.66620  1.000 52.21410 ? 416 HOH A O   1 
HETATM 3773 O O   . HOH H 5 .   ? 2.71989   -13.69547 53.86089  1.000 28.08108 ? 417 HOH A O   1 
HETATM 3774 O O   . HOH H 5 .   ? 30.59854  10.31884  56.47858  1.000 35.51819 ? 418 HOH A O   1 
HETATM 3775 O O   . HOH H 5 .   ? -7.69362  -21.60966 54.90280  1.000 39.73487 ? 419 HOH A O   1 
HETATM 3776 O O   . HOH H 5 .   ? 21.78660  -2.57865  36.51485  1.000 11.06495 ? 420 HOH A O   1 
HETATM 3777 O O   . HOH H 5 .   ? 4.15328   6.89771   33.95173  1.000 23.12535 ? 421 HOH A O   1 
HETATM 3778 O O   . HOH H 5 .   ? 17.96152  -6.61319  57.06739  1.000 15.99083 ? 422 HOH A O   1 
HETATM 3779 O O   . HOH H 5 .   ? -6.67852  4.96183   58.36453  1.000 47.74905 ? 423 HOH A O   1 
HETATM 3780 O O   . HOH H 5 .   ? 3.80741   -3.51902  33.29771  1.000 17.31649 ? 424 HOH A O   1 
HETATM 3781 O O   . HOH H 5 .   ? 28.28089  6.44730   45.34063  1.000 19.39799 ? 425 HOH A O   1 
HETATM 3782 O O   . HOH H 5 .   ? -8.37309  4.33062   53.96910  1.000 32.22179 ? 426 HOH A O   1 
HETATM 3783 O O   . HOH H 5 .   ? 29.05070  -4.66385  52.14260  1.000 29.77060 ? 427 HOH A O   1 
HETATM 3784 O O   . HOH H 5 .   ? 23.17348  -5.32235  60.11295  1.000 36.72867 ? 428 HOH A O   1 
HETATM 3785 O O   . HOH H 5 .   ? -13.17266 0.29759   52.76521  1.000 42.68520 ? 429 HOH A O   1 
HETATM 3786 O O   . HOH H 5 .   ? 34.33443  -15.73254 46.57138  1.000 29.11009 ? 430 HOH A O   1 
HETATM 3787 O O   . HOH H 5 .   ? 26.26938  -3.95227  50.52329  1.000 20.38218 ? 431 HOH A O   1 
HETATM 3788 O O   . HOH H 5 .   ? 3.51661   15.79549  58.21899  1.000 32.46005 ? 432 HOH A O   1 
HETATM 3789 O O   . HOH H 5 .   ? 7.04519   11.82883  49.80749  1.000 19.68245 ? 433 HOH A O   1 
HETATM 3790 O O   . HOH H 5 .   ? 13.63982  7.96277   30.39252  1.000 18.60537 ? 434 HOH A O   1 
HETATM 3791 O O   . HOH H 5 .   ? 26.61326  2.78121   34.68223  1.000 14.07945 ? 435 HOH A O   1 
HETATM 3792 O O   . HOH H 5 .   ? 25.46448  14.71918  49.10218  1.000 55.60720 ? 436 HOH A O   1 
HETATM 3793 O O   . HOH H 5 .   ? -1.29608  -0.53787  57.76736  1.000 21.41034 ? 437 HOH A O   1 
HETATM 3794 O O   . HOH H 5 .   ? 4.93602   -8.27072  62.62211  1.000 31.51347 ? 438 HOH A O   1 
HETATM 3795 O O   . HOH H 5 .   ? 17.29014  -11.77962 56.17139  1.000 24.69750 ? 439 HOH A O   1 
HETATM 3796 O O   . HOH H 5 .   ? 13.90405  3.98569   59.11685  1.000 12.41972 ? 440 HOH A O   1 
HETATM 3797 O O   . HOH H 5 .   ? 6.10529   -5.88272  57.09620  1.000 14.55986 ? 441 HOH A O   1 
HETATM 3798 O O   . HOH H 5 .   ? 14.33318  9.61786   58.24421  1.000 27.26405 ? 442 HOH A O   1 
HETATM 3799 O O   . HOH H 5 .   ? -0.44303  -2.39336  32.65639  1.000 35.42029 ? 443 HOH A O   1 
HETATM 3800 O O   . HOH H 5 .   ? 28.87840  -0.19658  54.11911  1.000 12.26464 ? 444 HOH A O   1 
HETATM 3801 O O   . HOH H 5 .   ? 5.66987   12.10419  52.19131  1.000 20.67048 ? 445 HOH A O   1 
HETATM 3802 O O   . HOH H 5 .   ? 24.30023  -13.94705 55.80512  1.000 44.78353 ? 446 HOH A O   1 
HETATM 3803 O O   . HOH H 5 .   ? 15.77233  10.87746  37.54641  1.000 18.70390 ? 447 HOH A O   1 
HETATM 3804 O O   . HOH H 5 .   ? 24.85694  -1.14055  59.66854  1.000 27.81935 ? 448 HOH A O   1 
HETATM 3805 O O   . HOH H 5 .   ? -4.931    -15.031   57.076    1.000 35.81003 ? 449 HOH A O   1 
HETATM 3806 O O   . HOH H 5 .   ? -7.64702  14.13009  42.93665  1.000 39.21576 ? 450 HOH A O   1 
HETATM 3807 O O   . HOH H 5 .   ? -8.85832  11.82612  42.70706  1.000 34.37148 ? 451 HOH A O   1 
HETATM 3808 O O   . HOH H 5 .   ? 16.83071  9.31931   33.23132  1.000 16.36227 ? 452 HOH A O   1 
HETATM 3809 O O   . HOH H 5 .   ? 21.34229  4.40710   61.11254  1.000 27.65263 ? 453 HOH A O   1 
HETATM 3810 O O   . HOH H 5 .   ? 25.15012  -11.86565 32.36755  1.000 27.55057 ? 454 HOH A O   1 
HETATM 3811 O O   . HOH H 5 .   ? 5.91989   -13.17071 60.60077  1.000 20.62769 ? 455 HOH A O   1 
HETATM 3812 O O   . HOH H 5 .   ? 6.58128   -2.62046  21.71865  1.000 33.88474 ? 456 HOH A O   1 
HETATM 3813 O O   . HOH H 5 .   ? 30.22080  2.94821   44.30586  1.000 16.10198 ? 457 HOH A O   1 
HETATM 3814 O O   . HOH H 5 .   ? 1.41877   -1.16471  61.29167  1.000 24.26689 ? 458 HOH A O   1 
HETATM 3815 O O   . HOH H 5 .   ? 5.63370   -10.01646 40.06727  1.000 43.00370 ? 459 HOH A O   1 
HETATM 3816 O O   . HOH H 5 .   ? 26.41892  -12.97693 54.72061  1.000 18.53373 ? 460 HOH A O   1 
HETATM 3817 O O   . HOH H 5 .   ? 4.15104   -4.74268  68.93096  1.000 50.85409 ? 461 HOH A O   1 
HETATM 3818 O O   . HOH H 5 .   ? 21.04651  1.50025   62.33654  1.000 19.83598 ? 462 HOH A O   1 
HETATM 3819 O O   . HOH H 5 .   ? 13.35449  -7.30536  22.06735  1.000 26.38787 ? 463 HOH A O   1 
HETATM 3820 O O   . HOH H 5 .   ? 6.31551   -6.77310  44.07785  1.000 27.29059 ? 464 HOH A O   1 
HETATM 3821 O O   . HOH H 5 .   ? -5.93408  15.45576  40.62523  1.000 37.58226 ? 465 HOH A O   1 
HETATM 3822 O O   . HOH H 5 .   ? 15.30320  -9.83133  60.63736  1.000 22.25244 ? 466 HOH A O   1 
HETATM 3823 O O   . HOH H 5 .   ? 24.28059  -11.45578 53.84167  1.000 16.29817 ? 467 HOH A O   1 
HETATM 3824 O O   . HOH H 5 .   ? 3.11105   -6.78388  44.82784  1.000 23.82698 ? 468 HOH A O   1 
HETATM 3825 O O   . HOH H 5 .   ? 17.06429  -9.29408  57.69715  1.000 20.36030 ? 469 HOH A O   1 
HETATM 3826 O O   . HOH H 5 .   ? 20.67944  -7.12717  57.77282  1.000 16.44378 ? 470 HOH A O   1 
HETATM 3827 O O   . HOH H 5 .   ? -7.31765  -0.54221  48.88147  1.000 33.54731 ? 471 HOH A O   1 
HETATM 3828 O O   . HOH H 5 .   ? 8.77168   -2.99882  43.50944  1.000 15.29633 ? 472 HOH A O   1 
HETATM 3829 O O   . HOH H 5 .   ? 4.83766   11.89178  43.48371  1.000 26.30565 ? 473 HOH A O   1 
HETATM 3830 O O   . HOH H 5 .   ? 21.66074  -6.20124  25.32887  1.000 35.19395 ? 474 HOH A O   1 
HETATM 3831 O O   . HOH H 5 .   ? 11.87580  -5.29798  40.51649  1.000 26.13059 ? 475 HOH A O   1 
HETATM 3832 O O   . HOH H 5 .   ? 20.93781  8.57911   43.06443  1.000 20.65098 ? 476 HOH A O   1 
HETATM 3833 O O   . HOH H 5 .   ? 9.87852   -11.35462 40.11094  1.000 41.54837 ? 477 HOH A O   1 
HETATM 3834 O O   . HOH H 5 .   ? -11.08656 4.70158   63.27324  1.000 53.66144 ? 478 HOH A O   1 
HETATM 3835 O O   . HOH H 5 .   ? -0.50467  -6.07278  34.38820  1.000 24.58704 ? 479 HOH A O   1 
HETATM 3836 O O   . HOH H 5 .   ? 7.39238   -3.05362  35.35746  1.000 13.23852 ? 480 HOH A O   1 
HETATM 3837 O O   . HOH H 5 .   ? 2.15326   2.33363   36.86138  1.000 24.55407 ? 481 HOH A O   1 
HETATM 3838 O O   . HOH H 5 .   ? -6.94149  3.38034   59.62463  1.000 39.07332 ? 482 HOH A O   1 
HETATM 3839 O O   . HOH H 5 .   ? -3.43947  -11.03002 58.96106  1.000 32.11641 ? 483 HOH A O   1 
HETATM 3840 O O   . HOH H 5 .   ? -3.14000  0.62302   42.97108  1.000 24.17267 ? 484 HOH A O   1 
HETATM 3841 O O   . HOH H 5 .   ? -5.24967  2.63593   42.66476  1.000 27.10606 ? 485 HOH A O   1 
HETATM 3842 O O   . HOH H 5 .   ? 17.66324  12.47632  31.01178  1.000 40.96932 ? 486 HOH A O   1 
HETATM 3843 O O   . HOH H 5 .   ? 5.98322   9.00000   25.34135  1.000 36.23861 ? 487 HOH A O   1 
HETATM 3844 O O   . HOH H 5 .   ? 26.45077  -13.05860 51.69312  1.000 32.14730 ? 488 HOH A O   1 
HETATM 3845 O O   . HOH H 5 .   ? -8.73181  10.65201  49.40657  1.000 33.09168 ? 489 HOH A O   1 
HETATM 3846 O O   . HOH H 5 .   ? 23.60971  4.15730   36.53822  1.000 16.28889 ? 490 HOH A O   1 
HETATM 3847 O O   . HOH H 5 .   ? 24.33501  16.52054  58.58450  1.000 43.94205 ? 491 HOH A O   1 
HETATM 3848 O O   . HOH H 5 .   ? 3.45061   -2.35249  47.46899  1.000 19.86404 ? 492 HOH A O   1 
HETATM 3849 O O   . HOH H 5 .   ? 6.81580   -6.00800  60.66092  1.000 27.17412 ? 493 HOH A O   1 
HETATM 3850 O O   . HOH H 5 .   ? 15.99984  9.31722   45.25725  1.000 31.54645 ? 494 HOH A O   1 
HETATM 3851 O O   . HOH H 5 .   ? 27.93391  -5.74877  57.85708  1.000 30.21082 ? 495 HOH A O   1 
HETATM 3852 O O   . HOH H 5 .   ? 14.00958  1.22665   22.04467  1.000 32.08431 ? 496 HOH A O   1 
HETATM 3853 O O   . HOH H 5 .   ? -0.16529  1.60277   37.63200  1.000 30.20126 ? 497 HOH A O   1 
HETATM 3854 O O   . HOH H 5 .   ? 21.35515  -10.51889 38.33647  1.000 22.42366 ? 498 HOH A O   1 
HETATM 3855 O O   . HOH H 5 .   ? 2.12091   8.43270   30.39921  1.000 41.10042 ? 499 HOH A O   1 
HETATM 3856 O O   . HOH H 5 .   ? -0.19866  0.30737   59.83211  1.000 23.73984 ? 500 HOH A O   1 
HETATM 3857 O O   . HOH H 5 .   ? 17.52138  -5.94378  40.50830  1.000 23.96119 ? 501 HOH A O   1 
HETATM 3858 O O   . HOH H 5 .   ? 37.22499  -7.85731  40.78082  1.000 30.22479 ? 502 HOH A O   1 
HETATM 3859 O O   . HOH H 5 .   ? 34.65237  -5.10334  42.97788  1.000 22.86452 ? 503 HOH A O   1 
HETATM 3860 O O   . HOH H 5 .   ? 5.01681   -3.46231  63.06683  1.000 39.84018 ? 504 HOH A O   1 
HETATM 3861 O O   . HOH H 5 .   ? 14.74667  -14.43156 53.92649  1.000 25.41948 ? 505 HOH A O   1 
HETATM 3862 O O   . HOH H 5 .   ? 29.98839  -1.23563  45.24589  1.000 34.77749 ? 506 HOH A O   1 
HETATM 3863 O O   . HOH H 5 .   ? 29.28230  0.61708   51.49876  1.000 20.81968 ? 507 HOH A O   1 
HETATM 3864 O O   . HOH H 5 .   ? 18.75577  8.07191   45.08713  1.000 23.43927 ? 508 HOH A O   1 
HETATM 3865 O O   . HOH H 5 .   ? 16.12451  15.76516  40.66794  1.000 47.10134 ? 509 HOH A O   1 
HETATM 3866 O O   . HOH H 5 .   ? 21.47642  0.52775   58.65330  1.000 17.62891 ? 510 HOH A O   1 
HETATM 3867 O O   . HOH H 5 .   ? -1.528    -11.925   61.723    1.000 36.43314 ? 511 HOH A O   1 
HETATM 3868 O O   . HOH H 5 .   ? 32.30267  -2.96367  41.58191  1.000 39.70250 ? 512 HOH A O   1 
HETATM 3869 O O   . HOH H 5 .   ? 12.94250  12.44826  52.47595  1.000 29.27254 ? 513 HOH A O   1 
HETATM 3870 O O   . HOH H 5 .   ? -9.87481  5.70255   53.38144  1.000 52.00718 ? 514 HOH A O   1 
HETATM 3871 O O   . HOH H 5 .   ? 32.02861  -5.04702  40.50617  1.000 25.72753 ? 515 HOH A O   1 
HETATM 3872 O O   . HOH H 5 .   ? 17.16945  -3.65476  37.85852  1.000 27.70013 ? 516 HOH A O   1 
HETATM 3873 O O   . HOH H 5 .   ? 0.04775   -8.51336  34.84860  1.000 32.41005 ? 517 HOH A O   1 
HETATM 3874 O O   . HOH H 5 .   ? 21.32802  5.41544   37.78469  1.000 7.05012  ? 518 HOH A O   1 
HETATM 3875 O O   . HOH H 5 .   ? -0.71533  -3.68913  48.70403  1.000 36.74507 ? 519 HOH A O   1 
HETATM 3876 O O   . HOH H 5 .   ? -0.65264  4.34538   38.67015  1.000 33.52756 ? 520 HOH A O   1 
HETATM 3877 O O   . HOH H 5 .   ? 30.28753  -0.10014  43.14747  1.000 28.49598 ? 521 HOH A O   1 
HETATM 3878 O O   . HOH H 5 .   ? 28.23743  -11.93745 57.72473  1.000 43.53676 ? 522 HOH A O   1 
HETATM 3879 O O   . HOH H 5 .   ? 30.05048  4.48295   36.69887  1.000 29.83929 ? 523 HOH A O   1 
HETATM 3880 O O   . HOH H 5 .   ? -1.10369  -4.87190  40.46394  1.000 40.05429 ? 524 HOH A O   1 
HETATM 3881 O O   . HOH H 5 .   ? -3.78357  10.14993  57.46370  1.000 40.05460 ? 525 HOH A O   1 
HETATM 3882 O O   . HOH H 5 .   ? -8.22532  6.94416   52.31901  1.000 46.32633 ? 526 HOH A O   1 
HETATM 3883 O O   . HOH H 5 .   ? 14.76230  11.86519  44.86555  1.000 30.52348 ? 527 HOH A O   1 
HETATM 3884 O O   . HOH H 5 .   ? 15.41143  -4.12379  36.28133  1.000 27.77398 ? 528 HOH A O   1 
HETATM 3885 O O   . HOH H 5 .   ? 41.49883  -14.27585 37.97958  1.000 38.87394 ? 529 HOH A O   1 
HETATM 3886 O O   . HOH H 5 .   ? 4.61596   -9.67414  34.72915  1.000 25.84766 ? 530 HOH A O   1 
HETATM 3887 O O   . HOH H 5 .   ? 4.42033   -8.52050  55.60704  1.000 22.41126 ? 531 HOH A O   1 
HETATM 3888 O O   . HOH H 5 .   ? 7.56083   -14.28161 55.17542  1.000 35.59472 ? 532 HOH A O   1 
HETATM 3889 O O   . HOH H 5 .   ? 12.29069  11.82775  28.00311  1.000 28.01425 ? 533 HOH A O   1 
HETATM 3890 O O   . HOH H 5 .   ? 28.04779  6.48815   48.17623  1.000 37.83942 ? 534 HOH A O   1 
HETATM 3891 O O   . HOH H 5 .   ? 22.54842  -13.18485 38.79093  1.000 21.88664 ? 535 HOH A O   1 
HETATM 3892 O O   . HOH H 5 .   ? 20.25820  -5.45214  63.57678  1.000 34.47200 ? 536 HOH A O   1 
HETATM 3893 O O   . HOH H 5 .   ? 11.08255  11.04666  60.54764  1.000 21.79682 ? 537 HOH A O   1 
HETATM 3894 O O   . HOH H 5 .   ? 0.27074   -4.38160  47.24447  1.000 42.43565 ? 538 HOH A O   1 
HETATM 3895 O O   . HOH H 5 .   ? 7.40166   -4.47517  45.29593  1.000 25.52341 ? 539 HOH A O   1 
HETATM 3896 O O   . HOH H 5 .   ? 11.20527  -6.18420  61.20028  1.000 26.71117 ? 540 HOH A O   1 
HETATM 3897 O O   . HOH H 5 .   ? -1.78834  -4.73256  50.84562  1.000 37.08730 ? 541 HOH A O   1 
HETATM 3898 O O   . HOH H 5 .   ? 0.02172   -6.73810  57.61947  1.000 33.54748 ? 542 HOH A O   1 
HETATM 3899 O O   . HOH H 5 .   ? 1.61870   -8.80558  54.12355  1.000 44.24226 ? 543 HOH A O   1 
HETATM 3900 O O   . HOH H 5 .   ? 12.43481  -19.60706 48.56245  1.000 45.73193 ? 544 HOH A O   1 
HETATM 3901 O O   . HOH H 5 .   ? 29.36488  -5.06435  33.49727  1.000 35.98849 ? 545 HOH A O   1 
HETATM 3902 O O   . HOH H 5 .   ? 6.51896   17.23565  36.08525  1.000 35.80804 ? 546 HOH A O   1 
HETATM 3903 O O   . HOH H 5 .   ? 4.42691   -0.20819  26.34816  1.000 34.94940 ? 547 HOH A O   1 
HETATM 3904 O O   . HOH H 5 .   ? -4.29366  -1.27392  40.98057  1.000 42.99333 ? 548 HOH A O   1 
HETATM 3905 O O   . HOH H 5 .   ? 26.62813  -13.81643 56.73118  1.000 50.04157 ? 549 HOH A O   1 
HETATM 3906 O O   . HOH H 5 .   ? -0.64076  -2.68760  40.83982  1.000 35.74794 ? 550 HOH A O   1 
HETATM 3907 O O   . HOH H 5 .   ? 17.844    17.523    51.162    1.000 50.91190 ? 551 HOH A O   1 
HETATM 3908 O O   . HOH H 5 .   ? 20.34894  -3.46321  24.68881  1.000 34.49808 ? 552 HOH A O   1 
HETATM 3909 O O   . HOH H 5 .   ? 22.37111  -12.88267 29.68998  1.000 37.77465 ? 553 HOH A O   1 
HETATM 3910 O O   . HOH H 5 .   ? 4.139     6.898     62.284    1.000 38.84792 ? 554 HOH A O   1 
HETATM 3911 O O   . HOH H 5 .   ? 3.404     -11.540   24.957    1.000 47.95724 ? 555 HOH A O   1 
HETATM 3912 O O   . HOH H 5 .   ? 4.82458   16.95675  37.32480  1.000 39.91371 ? 556 HOH A O   1 
HETATM 3913 O O   . HOH H 5 .   ? 28.36389  -1.99661  50.20820  1.000 31.67193 ? 557 HOH A O   1 
HETATM 3914 O O   . HOH H 5 .   ? 13.86351  -20.49812 46.87877  1.000 50.02527 ? 558 HOH A O   1 
HETATM 3915 O O   . HOH H 5 .   ? 22.72395  -15.50715 40.37735  1.000 43.51588 ? 559 HOH A O   1 
HETATM 3916 O O   . HOH H 5 .   ? 12.91040  12.17880  55.86752  1.000 43.24919 ? 560 HOH A O   1 
HETATM 3917 O O   . HOH H 5 .   ? 19.29722  -12.54099 30.00251  1.000 42.95740 ? 561 HOH A O   1 
HETATM 3918 O O   . HOH H 5 .   ? 5.53200   -10.98697 54.25898  1.000 35.08859 ? 562 HOH A O   1 
HETATM 3919 O O   . HOH H 5 .   ? 19.33512  10.86266  33.52853  1.000 47.64528 ? 563 HOH A O   1 
HETATM 3920 O O   . HOH H 5 .   ? 8.11167   13.95000  56.39876  1.000 30.12967 ? 564 HOH A O   1 
HETATM 3921 O O   . HOH H 5 .   ? 14.31286  -7.17339  17.48952  1.000 33.68386 ? 565 HOH A O   1 
HETATM 3922 O O   . HOH H 5 .   ? 20.90501  12.12084  34.84659  1.000 34.90490 ? 566 HOH A O   1 
HETATM 3923 O O   . HOH H 5 .   ? 14.56759  11.07498  56.95715  1.000 38.37043 ? 567 HOH A O   1 
HETATM 3924 O O   . HOH H 5 .   ? 30.52042  0.03248   49.87318  1.000 40.76179 ? 568 HOH A O   1 
HETATM 3925 O O   . HOH H 5 .   ? 0.54162   10.11726  35.01804  1.000 40.67317 ? 569 HOH A O   1 
HETATM 3926 O O   . HOH H 5 .   ? 0.22561   7.45121   35.98110  1.000 38.36461 ? 570 HOH A O   1 
HETATM 3927 O O   . HOH H 5 .   ? 14.21679  -9.09033  62.64594  1.000 34.06776 ? 571 HOH A O   1 
HETATM 3928 O O   . HOH H 5 .   ? 30.61001  10.06016  59.61283  1.000 46.71595 ? 572 HOH A O   1 
HETATM 3929 O O   . HOH H 5 .   ? 25.39371  -3.42624  60.36306  1.000 41.16699 ? 573 HOH A O   1 
HETATM 3930 O O   . HOH H 5 .   ? -11.59341 11.75783  44.49208  1.000 37.96688 ? 574 HOH A O   1 
HETATM 3931 O O   . HOH H 5 .   ? 27.69011  -3.21612  32.52412  1.000 33.08875 ? 575 HOH A O   1 
HETATM 3932 O O   . HOH H 5 .   ? 29.26616  -3.18575  54.19343  1.000 29.68678 ? 576 HOH A O   1 
HETATM 3933 O O   . HOH H 5 .   ? 8.41917   -1.47623  21.26061  1.000 40.99876 ? 577 HOH A O   1 
HETATM 3934 O O   . HOH H 5 .   ? 10.98597  13.29907  29.10693  1.000 31.89831 ? 578 HOH A O   1 
HETATM 3935 O O   . HOH H 5 .   ? 6.91857   13.85070  53.80648  1.000 34.83239 ? 579 HOH A O   1 
HETATM 3936 O O   . HOH H 5 .   ? 3.50698   -1.47212  23.96160  1.000 43.07975 ? 580 HOH A O   1 
HETATM 3937 O O   . HOH H 5 .   ? 1.47899   -4.66694  32.51712  1.000 34.74304 ? 581 HOH A O   1 
HETATM 3938 O O   . HOH H 5 .   ? 30.03010  -0.68190  47.87063  1.000 35.14743 ? 582 HOH A O   1 
HETATM 3939 O O   . HOH H 5 .   ? 16.92543  -22.00311 53.56206  1.000 43.19321 ? 583 HOH A O   1 
HETATM 3940 O O   . HOH H 5 .   ? 23.66755  1.00843   61.59230  1.000 25.43364 ? 584 HOH A O   1 
HETATM 3941 O O   . HOH H 5 .   ? 16.46494  -4.58305  20.64524  1.000 26.53382 ? 585 HOH A O   1 
HETATM 3942 O O   . HOH H 5 .   ? -7.07716  1.45564   43.65190  1.000 31.46726 ? 586 HOH A O   1 
HETATM 3943 O O   . HOH H 5 .   ? 21.02668  5.88334   63.45783  1.000 33.76118 ? 587 HOH A O   1 
HETATM 3944 O O   . HOH H 5 .   ? 27.84485  -4.26840  60.05362  1.000 30.60991 ? 588 HOH A O   1 
HETATM 3945 O O   . HOH H 5 .   ? 11.55109  14.86752  30.11917  1.000 39.04811 ? 589 HOH A O   1 
HETATM 3946 O O   . HOH H 5 .   ? 2.42181   8.83724   33.95175  1.000 28.74693 ? 590 HOH A O   1 
HETATM 3947 O O   . HOH H 5 .   ? -3.12545  4.17385   37.59520  1.000 41.60378 ? 591 HOH A O   1 
HETATM 3948 O O   . HOH H 5 .   ? 20.62297  -14.23796 37.86813  1.000 34.88685 ? 592 HOH A O   1 
HETATM 3949 O O   . HOH H 5 .   ? 34.61438  -9.40525  46.23284  1.000 47.70416 ? 593 HOH A O   1 
HETATM 3950 O O   . HOH H 5 .   ? 17.90095  -3.31874  21.14602  1.000 32.01997 ? 594 HOH A O   1 
HETATM 3951 O O   . HOH H 5 .   ? 20.75510  1.62900   64.89130  1.000 28.99057 ? 595 HOH A O   1 
HETATM 3952 O O   . HOH H 5 .   ? 20.58987  4.77638   65.75854  1.000 41.31599 ? 596 HOH A O   1 
HETATM 3953 O O   . HOH H 5 .   ? 32.95406  -5.51441  54.84763  1.000 44.47257 ? 597 HOH A O   1 
HETATM 3954 O O   . HOH H 5 .   ? 19.04307  -23.50086 52.00609  1.000 48.22638 ? 598 HOH A O   1 
HETATM 3955 O O   . HOH H 5 .   ? 5.019     -12.237   23.156    1.000 40.21956 ? 599 HOH A O   1 
HETATM 3956 O O   . HOH H 5 .   ? 31.20478  12.60511  44.22210  1.000 47.86420 ? 600 HOH A O   1 
HETATM 3957 O O   . HOH H 5 .   ? 34.05309  -6.01675  52.89161  1.000 45.46018 ? 601 HOH A O   1 
HETATM 3958 O O   . HOH H 5 .   ? 35.16599  -7.63057  47.04480  1.000 42.81742 ? 602 HOH A O   1 
HETATM 3959 O O   . HOH H 5 .   ? 25.22766  0.02099   64.01025  1.000 38.83911 ? 603 HOH A O   1 
HETATM 3960 O O   . HOH H 5 .   ? 33.040    -28.048   44.421    1.000 55.54918 ? 604 HOH A O   1 
HETATM 3961 O O   . HOH H 5 .   ? -1.49748  4.03532   34.35659  1.000 48.68513 ? 605 HOH A O   1 
HETATM 3962 O O   . HOH H 5 .   ? -3.12441  5.43270   35.98884  1.000 48.35208 ? 606 HOH A O   1 
HETATM 3963 O O   . HOH H 5 .   ? -1.91043  6.71541   34.43417  1.000 44.24597 ? 607 HOH A O   1 
HETATM 3964 O O   . HOH H 5 .   ? -0.49667  -0.17997  25.38274  1.000 39.08799 ? 608 HOH A O   1 
HETATM 3965 O O   . HOH I 5 .   ? 33.58113  13.82764  5.89136   1.000 38.35034 ? 401 HOH B O   1 
HETATM 3966 O O   . HOH I 5 .   ? 28.75172  18.83729  29.66537  1.000 34.37600 ? 402 HOH B O   1 
HETATM 3967 O O   . HOH I 5 .   ? 35.121    -21.374   -4.888    1.000 44.29062 ? 403 HOH B O   1 
HETATM 3968 O O   . HOH I 5 .   ? 14.74195  13.14747  26.50384  1.000 41.50813 ? 404 HOH B O   1 
HETATM 3969 O O   . HOH I 5 .   ? 24.62083  7.11780   10.92044  1.000 54.33396 ? 405 HOH B O   1 
HETATM 3970 O O   . HOH I 5 .   ? 43.84536  11.64775  -1.55934  1.000 54.67667 ? 406 HOH B O   1 
HETATM 3971 O O   . HOH I 5 .   ? 18.99951  5.52301   8.36708   1.000 54.70017 ? 407 HOH B O   1 
HETATM 3972 O O   . HOH I 5 .   ? 44.68494  0.72843   28.16991  1.000 53.31053 ? 408 HOH B O   1 
HETATM 3973 O O   . HOH I 5 .   ? 44.51940  5.75685   1.27868   1.000 35.53020 ? 409 HOH B O   1 
HETATM 3974 O O   . HOH I 5 .   ? 51.18740  -2.80885  5.72478   1.000 31.44829 ? 410 HOH B O   1 
HETATM 3975 O O   . HOH I 5 .   ? 14.68632  0.06836   15.35607  1.000 28.56374 ? 411 HOH B O   1 
HETATM 3976 O O   . HOH I 5 .   ? 33.36895  -10.05914 -6.33291  1.000 45.10831 ? 412 HOH B O   1 
HETATM 3977 O O   . HOH I 5 .   ? 49.66926  10.24867  26.75152  1.000 51.97352 ? 413 HOH B O   1 
HETATM 3978 O O   . HOH I 5 .   ? 24.53194  9.15012   6.53865   1.000 53.79189 ? 414 HOH B O   1 
HETATM 3979 O O   . HOH I 5 .   ? 47.50068  -4.27495  0.49337   1.000 37.99122 ? 415 HOH B O   1 
HETATM 3980 O O   . HOH I 5 .   ? 36.00525  -5.45315  6.11703   1.000 33.83297 ? 416 HOH B O   1 
HETATM 3981 O O   . HOH I 5 .   ? 49.76904  -9.05645  20.60239  1.000 44.76028 ? 417 HOH B O   1 
HETATM 3982 O O   . HOH I 5 .   ? 21.98494  -5.92285  21.85446  1.000 47.01217 ? 418 HOH B O   1 
HETATM 3983 O O   . HOH I 5 .   ? 22.94983  17.43824  27.80496  1.000 36.74742 ? 419 HOH B O   1 
HETATM 3984 O O   . HOH I 5 .   ? 42.27613  12.03098  20.78953  1.000 37.64326 ? 420 HOH B O   1 
HETATM 3985 O O   . HOH I 5 .   ? 41.74108  -22.75016 -0.09606  1.000 41.88068 ? 421 HOH B O   1 
HETATM 3986 O O   . HOH I 5 .   ? 25.98042  -0.95434  8.25457   1.000 38.53061 ? 422 HOH B O   1 
HETATM 3987 O O   . HOH I 5 .   ? 22.17025  -8.51665  11.35957  1.000 16.03381 ? 423 HOH B O   1 
HETATM 3988 O O   . HOH I 5 .   ? 11.91638  16.08333  22.65717  1.000 48.25330 ? 424 HOH B O   1 
HETATM 3989 O O   . HOH I 5 .   ? 21.46183  -7.11730  6.21375   1.000 35.21599 ? 425 HOH B O   1 
HETATM 3990 O O   . HOH I 5 .   ? 22.35379  -18.09650 5.58522   1.000 48.26493 ? 426 HOH B O   1 
HETATM 3991 O O   . HOH I 5 .   ? 19.98277  -7.80422  24.03961  1.000 28.56877 ? 427 HOH B O   1 
HETATM 3992 O O   . HOH I 5 .   ? 41.82357  -7.15683  7.87001   1.000 36.23285 ? 428 HOH B O   1 
HETATM 3993 O O   . HOH I 5 .   ? 25.49706  -12.83802 4.97116   1.000 34.56462 ? 429 HOH B O   1 
HETATM 3994 O O   . HOH I 5 .   ? 32.34126  6.64736   30.72295  1.000 27.01581 ? 430 HOH B O   1 
HETATM 3995 O O   . HOH I 5 .   ? 16.18707  -8.90040  19.68044  1.000 29.02910 ? 431 HOH B O   1 
HETATM 3996 O O   . HOH I 5 .   ? 49.44295  -6.72890  5.10916   1.000 41.32501 ? 432 HOH B O   1 
HETATM 3997 O O   . HOH I 5 .   ? 42.89274  -4.27327  8.88333   1.000 16.07875 ? 433 HOH B O   1 
HETATM 3998 O O   . HOH I 5 .   ? 11.14301  4.82602   19.64489  1.000 41.04631 ? 434 HOH B O   1 
HETATM 3999 O O   . HOH I 5 .   ? 12.27903  1.60384   13.39009  1.000 33.16728 ? 435 HOH B O   1 
HETATM 4000 O O   . HOH I 5 .   ? 46.54727  -9.54402  15.11795  1.000 38.88757 ? 436 HOH B O   1 
HETATM 4001 O O   . HOH I 5 .   ? 39.06258  9.65964   10.80385  1.000 20.26473 ? 437 HOH B O   1 
HETATM 4002 O O   . HOH I 5 .   ? 23.42186  -6.29042  23.42513  1.000 15.92721 ? 438 HOH B O   1 
HETATM 4003 O O   . HOH I 5 .   ? 23.95914  -16.09208 16.03906  1.000 33.87327 ? 439 HOH B O   1 
HETATM 4004 O O   . HOH I 5 .   ? 20.71935  8.04878   31.47664  1.000 13.52608 ? 440 HOH B O   1 
HETATM 4005 O O   . HOH I 5 .   ? 37.46472  -23.03597 -4.92280  1.000 48.33581 ? 441 HOH B O   1 
HETATM 4006 O O   . HOH I 5 .   ? 16.95135  8.54176   20.77567  1.000 23.16497 ? 442 HOH B O   1 
HETATM 4007 O O   . HOH I 5 .   ? 22.00929  -14.64486 11.94496  1.000 40.87580 ? 443 HOH B O   1 
HETATM 4008 O O   . HOH I 5 .   ? 43.58418  2.40824   0.91055   1.000 29.39274 ? 444 HOH B O   1 
HETATM 4009 O O   . HOH I 5 .   ? 51.57167  14.70227  7.84182   1.000 39.25028 ? 445 HOH B O   1 
HETATM 4010 O O   . HOH I 5 .   ? 40.83364  -18.31390 5.32752   1.000 36.24972 ? 446 HOH B O   1 
HETATM 4011 O O   . HOH I 5 .   ? 30.18494  18.10246  21.29094  1.000 29.86110 ? 447 HOH B O   1 
HETATM 4012 O O   . HOH I 5 .   ? 31.81805  -13.66940 11.00317  1.000 24.21057 ? 448 HOH B O   1 
HETATM 4013 O O   . HOH I 5 .   ? 30.53629  -3.45798  28.97097  1.000 17.77343 ? 449 HOH B O   1 
HETATM 4014 O O   . HOH I 5 .   ? 35.83362  7.32701   27.82541  1.000 22.92027 ? 450 HOH B O   1 
HETATM 4015 O O   . HOH I 5 .   ? 38.92004  10.21659  29.38832  1.000 37.05821 ? 451 HOH B O   1 
HETATM 4016 O O   . HOH I 5 .   ? 39.70961  13.88603  10.73807  1.000 29.71251 ? 452 HOH B O   1 
HETATM 4017 O O   . HOH I 5 .   ? 18.38340  2.30778   14.42680  1.000 18.35427 ? 453 HOH B O   1 
HETATM 4018 O O   . HOH I 5 .   ? 21.21195  -14.06463 19.86172  1.000 27.85268 ? 454 HOH B O   1 
HETATM 4019 O O   . HOH I 5 .   ? 30.91677  3.02891   29.09671  1.000 16.34615 ? 455 HOH B O   1 
HETATM 4020 O O   . HOH I 5 .   ? 26.51452  17.31858  31.36043  1.000 35.86246 ? 456 HOH B O   1 
HETATM 4021 O O   . HOH I 5 .   ? 37.72358  13.20981  17.53749  1.000 25.93891 ? 457 HOH B O   1 
HETATM 4022 O O   . HOH I 5 .   ? 23.62530  11.42528  33.88324  1.000 25.54796 ? 458 HOH B O   1 
HETATM 4023 O O   . HOH I 5 .   ? 36.89146  -0.69098  28.39554  1.000 27.40151 ? 459 HOH B O   1 
HETATM 4024 O O   . HOH I 5 .   ? 40.68598  2.38923   8.65875   1.000 29.57316 ? 460 HOH B O   1 
HETATM 4025 O O   . HOH I 5 .   ? 19.41637  -10.83321 8.85573   1.000 37.08153 ? 461 HOH B O   1 
HETATM 4026 O O   . HOH I 5 .   ? 24.37412  -13.17637 2.36088   1.000 39.30884 ? 462 HOH B O   1 
HETATM 4027 O O   . HOH I 5 .   ? 30.93549  15.75332  11.85778  1.000 33.92363 ? 463 HOH B O   1 
HETATM 4028 O O   . HOH I 5 .   ? 14.32682  5.15080   20.72341  1.000 21.30392 ? 464 HOH B O   1 
HETATM 4029 O O   . HOH I 5 .   ? 22.29376  -11.35561 10.86404  1.000 25.18483 ? 465 HOH B O   1 
HETATM 4030 O O   . HOH I 5 .   ? 27.64223  -13.86415 2.23168   1.000 34.15201 ? 466 HOH B O   1 
HETATM 4031 O O   . HOH I 5 .   ? 48.88715  4.28389   18.61744  1.000 36.33225 ? 467 HOH B O   1 
HETATM 4032 O O   . HOH I 5 .   ? 27.02105  8.30655   15.36574  1.000 21.32765 ? 468 HOH B O   1 
HETATM 4033 O O   . HOH I 5 .   ? 36.54303  -3.41203  24.30236  1.000 32.35543 ? 469 HOH B O   1 
HETATM 4034 O O   . HOH I 5 .   ? 28.44408  3.22614   30.18406  1.000 9.82951  ? 470 HOH B O   1 
HETATM 4035 O O   . HOH I 5 .   ? 48.32568  1.27989   18.95169  1.000 34.11114 ? 471 HOH B O   1 
HETATM 4036 O O   . HOH I 5 .   ? 29.93649  16.01655  18.51041  1.000 30.82924 ? 472 HOH B O   1 
HETATM 4037 O O   . HOH I 5 .   ? 40.63293  -14.42609 18.77834  1.000 30.73117 ? 473 HOH B O   1 
HETATM 4038 O O   . HOH I 5 .   ? 7.02107   2.93713   19.11990  1.000 52.49874 ? 474 HOH B O   1 
HETATM 4039 O O   . HOH I 5 .   ? 17.54683  -13.15370 14.01788  1.000 36.66680 ? 475 HOH B O   1 
HETATM 4040 O O   . HOH I 5 .   ? 15.53733  6.99183   22.20690  1.000 15.17935 ? 476 HOH B O   1 
HETATM 4041 O O   . HOH I 5 .   ? 40.47828  -15.47381 14.40043  1.000 25.66949 ? 477 HOH B O   1 
HETATM 4042 O O   . HOH I 5 .   ? 21.00114  -4.59353  4.27233   1.000 35.17992 ? 478 HOH B O   1 
HETATM 4043 O O   . HOH I 5 .   ? 51.77156  5.17665   24.66198  1.000 54.70894 ? 479 HOH B O   1 
HETATM 4044 O O   . HOH I 5 .   ? 43.52461  -13.38974 9.24851   1.000 35.60151 ? 480 HOH B O   1 
HETATM 4045 O O   . HOH I 5 .   ? 23.81125  -6.48857  27.36011  1.000 40.12642 ? 481 HOH B O   1 
HETATM 4046 O O   . HOH I 5 .   ? 38.80767  -3.54256  -10.49844 1.000 56.94116 ? 482 HOH B O   1 
HETATM 4047 O O   . HOH I 5 .   ? 40.12437  0.64583   -0.59361  1.000 30.54567 ? 483 HOH B O   1 
HETATM 4048 O O   . HOH I 5 .   ? 30.81704  -17.72489 14.51103  1.000 22.40389 ? 484 HOH B O   1 
HETATM 4049 O O   . HOH I 5 .   ? 23.08004  17.71581  20.18763  1.000 35.97061 ? 485 HOH B O   1 
HETATM 4050 O O   . HOH I 5 .   ? 10.73145  10.57336  25.03385  1.000 30.96555 ? 486 HOH B O   1 
HETATM 4051 O O   . HOH I 5 .   ? 38.47591  -3.77769  1.82666   1.000 28.07210 ? 487 HOH B O   1 
HETATM 4052 O O   . HOH I 5 .   ? 20.45569  3.54222   1.45054   1.000 36.21411 ? 488 HOH B O   1 
HETATM 4053 O O   . HOH I 5 .   ? 38.42855  1.09340   -8.88676  1.000 44.25740 ? 489 HOH B O   1 
HETATM 4054 O O   . HOH I 5 .   ? 18.68218  3.89853   11.98172  1.000 28.38209 ? 490 HOH B O   1 
HETATM 4055 O O   . HOH I 5 .   ? 18.59922  -1.35042  24.81311  1.000 20.87387 ? 491 HOH B O   1 
HETATM 4056 O O   . HOH I 5 .   ? 13.72243  -2.05832  12.35146  1.000 32.82750 ? 492 HOH B O   1 
HETATM 4057 O O   . HOH I 5 .   ? 20.29835  -4.61227  22.06346  1.000 32.26040 ? 493 HOH B O   1 
HETATM 4058 O O   . HOH I 5 .   ? 49.460    -6.690    0.946     1.000 35.64908 ? 494 HOH B O   1 
HETATM 4059 O O   . HOH I 5 .   ? 29.67333  4.77174   33.61502  1.000 30.13539 ? 495 HOH B O   1 
HETATM 4060 O O   . HOH I 5 .   ? 44.04332  1.15394   -10.10758 1.000 34.62649 ? 496 HOH B O   1 
HETATM 4061 O O   . HOH I 5 .   ? 24.08081  -13.08492 17.92586  1.000 23.11835 ? 497 HOH B O   1 
HETATM 4062 O O   . HOH I 5 .   ? 27.62398  -3.63202  29.55992  1.000 24.42025 ? 498 HOH B O   1 
HETATM 4063 O O   . HOH I 5 .   ? 38.01320  -2.07891  25.99691  1.000 29.92345 ? 499 HOH B O   1 
HETATM 4064 O O   . HOH I 5 .   ? 49.44719  13.89625  28.69786  1.000 48.85186 ? 500 HOH B O   1 
HETATM 4065 O O   . HOH I 5 .   ? 42.46030  6.96313   32.99783  1.000 45.77932 ? 501 HOH B O   1 
HETATM 4066 O O   . HOH I 5 .   ? 48.19848  -8.62677  12.62091  1.000 32.21294 ? 502 HOH B O   1 
HETATM 4067 O O   . HOH I 5 .   ? 24.68773  11.99538  15.30992  1.000 30.55627 ? 503 HOH B O   1 
HETATM 4068 O O   . HOH I 5 .   ? 38.76010  -15.07747 10.97152  1.000 31.50818 ? 504 HOH B O   1 
HETATM 4069 O O   . HOH I 5 .   ? 37.61104  -15.69224 19.62832  1.000 33.96120 ? 505 HOH B O   1 
HETATM 4070 O O   . HOH I 5 .   ? 40.06433  14.19752  22.93561  1.000 38.95086 ? 506 HOH B O   1 
HETATM 4071 O O   . HOH I 5 .   ? 39.32909  -5.49950  -9.21852  1.000 65.30467 ? 507 HOH B O   1 
HETATM 4072 O O   . HOH I 5 .   ? 44.45131  -0.39456  23.35628  1.000 31.54919 ? 508 HOH B O   1 
HETATM 4073 O O   . HOH I 5 .   ? 32.06918  0.94059   4.88193   1.000 50.11171 ? 509 HOH B O   1 
HETATM 4074 O O   . HOH I 5 .   ? 42.32448  -14.74955 5.48143   1.000 26.96929 ? 510 HOH B O   1 
HETATM 4075 O O   . HOH I 5 .   ? 40.05870  -0.00004  9.42904   1.000 38.24633 ? 511 HOH B O   1 
HETATM 4076 O O   . HOH I 5 .   ? 45.06350  -4.92477  -1.49421  1.000 48.14003 ? 512 HOH B O   1 
HETATM 4077 O O   . HOH I 5 .   ? 11.07621  3.70134   27.03020  1.000 24.76197 ? 513 HOH B O   1 
HETATM 4078 O O   . HOH I 5 .   ? 33.98553  17.24273  14.03556  1.000 47.68640 ? 514 HOH B O   1 
HETATM 4079 O O   . HOH I 5 .   ? 32.03126  14.59113  14.48168  1.000 39.75406 ? 515 HOH B O   1 
HETATM 4080 O O   . HOH I 5 .   ? 16.80276  -0.95789  22.98547  1.000 15.19564 ? 516 HOH B O   1 
HETATM 4081 O O   . HOH I 5 .   ? 20.46486  -7.96737  9.13312   1.000 32.32055 ? 517 HOH B O   1 
HETATM 4082 O O   . HOH I 5 .   ? 33.12414  -17.17065 14.75702  1.000 35.84570 ? 518 HOH B O   1 
HETATM 4083 O O   . HOH I 5 .   ? 14.21837  -4.65298  18.72649  1.000 41.62312 ? 519 HOH B O   1 
HETATM 4084 O O   . HOH I 5 .   ? 36.60802  2.02129   32.66576  1.000 33.22924 ? 520 HOH B O   1 
HETATM 4085 O O   . HOH I 5 .   ? 23.48170  16.56513  31.30163  1.000 47.04034 ? 521 HOH B O   1 
HETATM 4086 O O   . HOH I 5 .   ? 46.21997  2.68175   -0.10080  1.000 34.13435 ? 522 HOH B O   1 
HETATM 4087 O O   . HOH I 5 .   ? 51.98134  9.16776   2.16614   1.000 37.78701 ? 523 HOH B O   1 
HETATM 4088 O O   . HOH I 5 .   ? 16.16120  7.73203   31.48246  1.000 27.09124 ? 524 HOH B O   1 
HETATM 4089 O O   . HOH I 5 .   ? 35.96773  12.47019  4.35871   1.000 38.88024 ? 525 HOH B O   1 
HETATM 4090 O O   . HOH I 5 .   ? 31.13671  7.13057   32.87121  1.000 25.74022 ? 526 HOH B O   1 
HETATM 4091 O O   . HOH I 5 .   ? 38.77031  -3.31931  -12.92899 1.000 52.50869 ? 527 HOH B O   1 
HETATM 4092 O O   . HOH I 5 .   ? 11.92300  2.97868   21.87075  1.000 30.08117 ? 528 HOH B O   1 
HETATM 4093 O O   . HOH I 5 .   ? 29.15178  -11.04394 26.52402  1.000 13.36012 ? 529 HOH B O   1 
HETATM 4094 O O   . HOH I 5 .   ? 35.65004  7.49773   32.87837  1.000 40.94817 ? 530 HOH B O   1 
HETATM 4095 O O   . HOH I 5 .   ? 36.82314  17.94247  32.40201  1.000 36.92204 ? 531 HOH B O   1 
HETATM 4096 O O   . HOH I 5 .   ? 32.66861  11.09084  4.98878   1.000 35.71990 ? 532 HOH B O   1 
HETATM 4097 O O   . HOH I 5 .   ? 36.22699  -15.89655 12.23919  1.000 46.92994 ? 533 HOH B O   1 
HETATM 4098 O O   . HOH I 5 .   ? 17.09800  -7.89211  9.90454   1.000 34.60701 ? 534 HOH B O   1 
HETATM 4099 O O   . HOH I 5 .   ? 33.23359  16.39314  15.25855  1.000 50.07341 ? 535 HOH B O   1 
HETATM 4100 O O   . HOH I 5 .   ? 38.18559  -5.34933  -15.18121 1.000 48.90005 ? 536 HOH B O   1 
HETATM 4101 O O   . HOH I 5 .   ? 16.11757  -10.83674 11.72352  1.000 38.74554 ? 537 HOH B O   1 
HETATM 4102 O O   . HOH I 5 .   ? 48.52600  4.39850   0.00000   0.50  45.13684 ? 538 HOH B O   1 
HETATM 4103 O O   . HOH I 5 .   ? 34.64887  -16.96088 12.72551  1.000 40.80672 ? 539 HOH B O   1 
HETATM 4104 O O   . HOH I 5 .   ? 30.57417  4.86779   12.13894  1.000 22.44788 ? 540 HOH B O   1 
HETATM 4105 O O   . HOH I 5 .   ? 12.61702  1.69611   18.36685  1.000 37.37279 ? 541 HOH B O   1 
HETATM 4106 O O   . HOH I 5 .   ? 34.70730  8.27899   30.26721  1.000 34.18159 ? 542 HOH B O   1 
HETATM 4107 O O   . HOH I 5 .   ? 44.890    -4.484    -4.008    1.000 40.16829 ? 543 HOH B O   1 
HETATM 4108 O O   . HOH I 5 .   ? 27.96864  18.90538  19.71288  1.000 38.51573 ? 544 HOH B O   1 
HETATM 4109 O O   . HOH I 5 .   ? 15.81928  17.36213  27.09314  1.000 40.82022 ? 545 HOH B O   1 
HETATM 4110 O O   . HOH I 5 .   ? 27.76185  1.72912   32.33126  1.000 15.03358 ? 546 HOH B O   1 
HETATM 4111 O O   . HOH I 5 .   ? 5.70314   3.70669   17.98989  1.000 43.45096 ? 547 HOH B O   1 
HETATM 4112 O O   . HOH I 5 .   ? 31.66167  0.70070   30.96930  1.000 28.36316 ? 548 HOH B O   1 
HETATM 4113 O O   . HOH I 5 .   ? 30.52091  -10.13649 27.49500  1.000 28.06034 ? 549 HOH B O   1 
HETATM 4114 O O   . HOH I 5 .   ? 25.67087  8.97618   8.21525   1.000 59.86149 ? 550 HOH B O   1 
HETATM 4115 O O   . HOH I 5 .   ? 32.53490  5.12473   12.72447  1.000 32.94280 ? 551 HOH B O   1 
HETATM 4116 O O   . HOH I 5 .   ? 31.88352  -1.76306  30.55604  1.000 39.49994 ? 552 HOH B O   1 
HETATM 4117 O O   . HOH I 5 .   ? 46.457    -8.410    -6.382    1.000 48.19899 ? 553 HOH B O   1 
HETATM 4118 O O   . HOH I 5 .   ? 12.58169  -0.06483  16.99962  1.000 46.42511 ? 554 HOH B O   1 
HETATM 4119 O O   . HOH I 5 .   ? 16.16271  -7.05871  21.63019  1.000 34.32131 ? 555 HOH B O   1 
HETATM 4120 O O   . HOH I 5 .   ? 32.51824  -5.32454  29.40513  1.000 34.15864 ? 556 HOH B O   1 
HETATM 4121 O O   . HOH I 5 .   ? 36.51868  10.62885  30.62202  1.000 33.80692 ? 557 HOH B O   1 
HETATM 4122 O O   . HOH I 5 .   ? 33.10580  -6.87699  26.95064  1.000 32.09151 ? 558 HOH B O   1 
HETATM 4123 O O   . HOH I 5 .   ? 8.09701   10.49155  23.89891  1.000 41.84533 ? 559 HOH B O   1 
HETATM 4124 O O   . HOH I 5 .   ? 17.53282  18.35581  26.24421  1.000 47.35184 ? 560 HOH B O   1 
HETATM 4125 O O   . HOH I 5 .   ? 21.95438  -16.60534 18.35458  1.000 33.18677 ? 561 HOH B O   1 
HETATM 4126 O O   . HOH I 5 .   ? 17.29975  -9.85452  10.01389  1.000 40.10492 ? 562 HOH B O   1 
HETATM 4127 O O   . HOH I 5 .   ? 38.21624  -16.76470 13.30148  1.000 57.59686 ? 563 HOH B O   1 
HETATM 4128 O O   . HOH I 5 .   ? 33.79494  0.95598   6.19045   1.000 52.08621 ? 564 HOH B O   1 
HETATM 4129 O O   . HOH I 5 .   ? 29.21766  -0.54403  32.26662  1.000 26.73163 ? 565 HOH B O   1 
HETATM 4130 O O   . HOH I 5 .   ? 36.415    -22.970   -10.167   1.000 36.05627 ? 566 HOH B O   1 
HETATM 4131 O O   . HOH I 5 .   ? 35.41419  -5.64614  26.08861  1.000 33.75770 ? 567 HOH B O   1 
HETATM 4132 O O   . HOH I 5 .   ? 46.868    19.080    26.934    1.000 43.22718 ? 568 HOH B O   1 
# 
