data_9DQF
# 
_entry.id   9DQF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQF         pdb_00009dqf 10.2210/pdb9dqf/pdb 
WWPDB D_1000288627 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-14 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQF 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              john.bruning@adelaide.edu.au 
_pdbx_contact_author.name_first         John 
_pdbx_contact_author.name_last          Bruning 
_pdbx_contact_author.name_mi            B 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6919-1824 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Pederick, J.L.' 1 0000-0003-4048-9771 
'Bruning, J.B.'  2 0000-0002-6919-1824 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Protein Sci.' 
_citation.journal_id_ASTM           PRCIEI 
_citation.journal_id_CSD            0795 
_citation.journal_id_ISSN           1469-896X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            34 
_citation.language                  ? 
_citation.page_first                e70111 
_citation.page_last                 e70111 
_citation.title                     
;Functional and structural characterization of Staphylococcus aureus N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) reveals a redox-sensitive acetyltransferase activity.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/pro.70111 
_citation.pdbx_database_id_PubMed   40143772 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pederick, J.L.' 1 0000-0003-4048-9771 
primary 'Kumar, A.'      2 ?                   
primary 'Pukala, T.L.'   3 ?                   
primary 'Bruning, J.B.'  4 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Bifunctional protein GlmU' 49722.773 1   2.7.7.23,2.3.1.157 ? ? ? 
2 non-polymer syn 'ACETYL COENZYME *A'        809.571   1   ?                  ? ? ? 
3 non-polymer nat 'CITRIC ACID'               192.124   1   ?                  ? ? ? 
4 water       nat water                       18.015    190 ?                  ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGHHHHHHGSMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYS
FQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLVTLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLE
RIVEEKDATQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRV
MLSQAEKAMQRRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQ
QSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGEN
KFKTIVGKDSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGHHHHHHGSMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYS
FQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLVTLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLE
RIVEEKDATQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRV
MLSQAEKAMQRRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQ
QSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGEN
KFKTIVGKDSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ACETYL COENZYME *A' ACO 
3 'CITRIC ACID'        CIT 
4 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   GLY n 
1 10  SER n 
1 11  MET n 
1 12  ARG n 
1 13  ARG n 
1 14  HIS n 
1 15  ALA n 
1 16  ILE n 
1 17  ILE n 
1 18  LEU n 
1 19  ALA n 
1 20  ALA n 
1 21  GLY n 
1 22  LYS n 
1 23  GLY n 
1 24  THR n 
1 25  ARG n 
1 26  MET n 
1 27  LYS n 
1 28  SER n 
1 29  LYS n 
1 30  LYS n 
1 31  TYR n 
1 32  LYS n 
1 33  VAL n 
1 34  LEU n 
1 35  HIS n 
1 36  GLU n 
1 37  VAL n 
1 38  ALA n 
1 39  GLY n 
1 40  LYS n 
1 41  PRO n 
1 42  MET n 
1 43  VAL n 
1 44  GLU n 
1 45  HIS n 
1 46  VAL n 
1 47  LEU n 
1 48  GLU n 
1 49  SER n 
1 50  VAL n 
1 51  LYS n 
1 52  GLY n 
1 53  SER n 
1 54  GLY n 
1 55  VAL n 
1 56  ASP n 
1 57  GLN n 
1 58  VAL n 
1 59  VAL n 
1 60  THR n 
1 61  ILE n 
1 62  VAL n 
1 63  GLY n 
1 64  HIS n 
1 65  GLY n 
1 66  ALA n 
1 67  GLU n 
1 68  SER n 
1 69  VAL n 
1 70  LYS n 
1 71  GLY n 
1 72  HIS n 
1 73  LEU n 
1 74  GLY n 
1 75  GLU n 
1 76  ARG n 
1 77  SER n 
1 78  LEU n 
1 79  TYR n 
1 80  SER n 
1 81  PHE n 
1 82  GLN n 
1 83  GLU n 
1 84  GLU n 
1 85  GLN n 
1 86  LEU n 
1 87  GLY n 
1 88  THR n 
1 89  ALA n 
1 90  HIS n 
1 91  ALA n 
1 92  VAL n 
1 93  GLN n 
1 94  MET n 
1 95  ALA n 
1 96  LYS n 
1 97  SER n 
1 98  HIS n 
1 99  LEU n 
1 100 GLU n 
1 101 ASP n 
1 102 LYS n 
1 103 GLU n 
1 104 GLY n 
1 105 THR n 
1 106 THR n 
1 107 ILE n 
1 108 VAL n 
1 109 VAL n 
1 110 CYS n 
1 111 GLY n 
1 112 ASP n 
1 113 THR n 
1 114 PRO n 
1 115 LEU n 
1 116 ILE n 
1 117 THR n 
1 118 LYS n 
1 119 GLU n 
1 120 THR n 
1 121 LEU n 
1 122 VAL n 
1 123 THR n 
1 124 LEU n 
1 125 ILE n 
1 126 ALA n 
1 127 HIS n 
1 128 HIS n 
1 129 GLU n 
1 130 ASP n 
1 131 ALA n 
1 132 ASN n 
1 133 ALA n 
1 134 GLN n 
1 135 ALA n 
1 136 THR n 
1 137 VAL n 
1 138 LEU n 
1 139 SER n 
1 140 ALA n 
1 141 SER n 
1 142 ILE n 
1 143 GLN n 
1 144 GLN n 
1 145 PRO n 
1 146 TYR n 
1 147 GLY n 
1 148 TYR n 
1 149 GLY n 
1 150 ARG n 
1 151 ILE n 
1 152 VAL n 
1 153 ARG n 
1 154 ASN n 
1 155 ALA n 
1 156 SER n 
1 157 GLY n 
1 158 ARG n 
1 159 LEU n 
1 160 GLU n 
1 161 ARG n 
1 162 ILE n 
1 163 VAL n 
1 164 GLU n 
1 165 GLU n 
1 166 LYS n 
1 167 ASP n 
1 168 ALA n 
1 169 THR n 
1 170 GLN n 
1 171 ALA n 
1 172 GLU n 
1 173 LYS n 
1 174 ASP n 
1 175 ILE n 
1 176 ASN n 
1 177 GLU n 
1 178 ILE n 
1 179 SER n 
1 180 SER n 
1 181 GLY n 
1 182 ILE n 
1 183 PHE n 
1 184 ALA n 
1 185 PHE n 
1 186 ASN n 
1 187 ASN n 
1 188 LYS n 
1 189 THR n 
1 190 LEU n 
1 191 PHE n 
1 192 GLU n 
1 193 LYS n 
1 194 LEU n 
1 195 THR n 
1 196 GLN n 
1 197 VAL n 
1 198 LYS n 
1 199 ASN n 
1 200 ASP n 
1 201 ASN n 
1 202 ALA n 
1 203 GLN n 
1 204 GLY n 
1 205 GLU n 
1 206 TYR n 
1 207 TYR n 
1 208 LEU n 
1 209 PRO n 
1 210 ASP n 
1 211 VAL n 
1 212 LEU n 
1 213 SER n 
1 214 LEU n 
1 215 ILE n 
1 216 LEU n 
1 217 ASN n 
1 218 ASP n 
1 219 GLY n 
1 220 GLY n 
1 221 ILE n 
1 222 VAL n 
1 223 GLU n 
1 224 VAL n 
1 225 TYR n 
1 226 ARG n 
1 227 THR n 
1 228 ASN n 
1 229 ASP n 
1 230 VAL n 
1 231 GLU n 
1 232 GLU n 
1 233 ILE n 
1 234 MET n 
1 235 GLY n 
1 236 VAL n 
1 237 ASN n 
1 238 ASP n 
1 239 ARG n 
1 240 VAL n 
1 241 MET n 
1 242 LEU n 
1 243 SER n 
1 244 GLN n 
1 245 ALA n 
1 246 GLU n 
1 247 LYS n 
1 248 ALA n 
1 249 MET n 
1 250 GLN n 
1 251 ARG n 
1 252 ARG n 
1 253 THR n 
1 254 ASN n 
1 255 HIS n 
1 256 TYR n 
1 257 HIS n 
1 258 MET n 
1 259 LEU n 
1 260 ASN n 
1 261 GLY n 
1 262 VAL n 
1 263 THR n 
1 264 ILE n 
1 265 ILE n 
1 266 ASP n 
1 267 PRO n 
1 268 ASP n 
1 269 SER n 
1 270 THR n 
1 271 TYR n 
1 272 ILE n 
1 273 GLY n 
1 274 PRO n 
1 275 ASP n 
1 276 VAL n 
1 277 THR n 
1 278 ILE n 
1 279 GLY n 
1 280 SER n 
1 281 ASP n 
1 282 THR n 
1 283 VAL n 
1 284 ILE n 
1 285 GLU n 
1 286 PRO n 
1 287 GLY n 
1 288 VAL n 
1 289 ARG n 
1 290 ILE n 
1 291 ASN n 
1 292 GLY n 
1 293 ARG n 
1 294 THR n 
1 295 GLU n 
1 296 ILE n 
1 297 GLY n 
1 298 GLU n 
1 299 ASP n 
1 300 VAL n 
1 301 VAL n 
1 302 ILE n 
1 303 GLY n 
1 304 GLN n 
1 305 TYR n 
1 306 SER n 
1 307 GLU n 
1 308 ILE n 
1 309 ASN n 
1 310 ASN n 
1 311 SER n 
1 312 THR n 
1 313 ILE n 
1 314 GLU n 
1 315 ASN n 
1 316 GLY n 
1 317 ALA n 
1 318 CYS n 
1 319 ILE n 
1 320 GLN n 
1 321 GLN n 
1 322 SER n 
1 323 VAL n 
1 324 VAL n 
1 325 ASN n 
1 326 ASP n 
1 327 ALA n 
1 328 SER n 
1 329 VAL n 
1 330 GLY n 
1 331 ALA n 
1 332 ASN n 
1 333 THR n 
1 334 LYS n 
1 335 VAL n 
1 336 GLY n 
1 337 PRO n 
1 338 PHE n 
1 339 ALA n 
1 340 GLN n 
1 341 LEU n 
1 342 ARG n 
1 343 PRO n 
1 344 GLY n 
1 345 ALA n 
1 346 GLN n 
1 347 LEU n 
1 348 GLY n 
1 349 ALA n 
1 350 ASP n 
1 351 VAL n 
1 352 LYS n 
1 353 VAL n 
1 354 GLY n 
1 355 ASN n 
1 356 PHE n 
1 357 VAL n 
1 358 GLU n 
1 359 ILE n 
1 360 LYS n 
1 361 LYS n 
1 362 ALA n 
1 363 ASP n 
1 364 LEU n 
1 365 LYS n 
1 366 ASP n 
1 367 GLY n 
1 368 ALA n 
1 369 LYS n 
1 370 VAL n 
1 371 SER n 
1 372 HIS n 
1 373 LEU n 
1 374 SER n 
1 375 TYR n 
1 376 ILE n 
1 377 GLY n 
1 378 ASP n 
1 379 ALA n 
1 380 VAL n 
1 381 ILE n 
1 382 GLY n 
1 383 GLU n 
1 384 ARG n 
1 385 THR n 
1 386 ASN n 
1 387 ILE n 
1 388 GLY n 
1 389 CYS n 
1 390 GLY n 
1 391 THR n 
1 392 ILE n 
1 393 THR n 
1 394 VAL n 
1 395 ASN n 
1 396 TYR n 
1 397 ASP n 
1 398 GLY n 
1 399 GLU n 
1 400 ASN n 
1 401 LYS n 
1 402 PHE n 
1 403 LYS n 
1 404 THR n 
1 405 ILE n 
1 406 VAL n 
1 407 GLY n 
1 408 LYS n 
1 409 ASP n 
1 410 SER n 
1 411 PHE n 
1 412 VAL n 
1 413 GLY n 
1 414 CYS n 
1 415 ASN n 
1 416 VAL n 
1 417 ASN n 
1 418 LEU n 
1 419 VAL n 
1 420 ALA n 
1 421 PRO n 
1 422 VAL n 
1 423 THR n 
1 424 ILE n 
1 425 GLY n 
1 426 ASP n 
1 427 ASP n 
1 428 VAL n 
1 429 LEU n 
1 430 VAL n 
1 431 ALA n 
1 432 ALA n 
1 433 GLY n 
1 434 SER n 
1 435 THR n 
1 436 ILE n 
1 437 THR n 
1 438 ASP n 
1 439 ASP n 
1 440 VAL n 
1 441 PRO n 
1 442 ASN n 
1 443 ASP n 
1 444 SER n 
1 445 LEU n 
1 446 ALA n 
1 447 VAL n 
1 448 ALA n 
1 449 ARG n 
1 450 ALA n 
1 451 ARG n 
1 452 GLN n 
1 453 THR n 
1 454 THR n 
1 455 LYS n 
1 456 GLU n 
1 457 GLY n 
1 458 TYR n 
1 459 ARG n 
1 460 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   460 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'glmU, SAOUHSC_00471' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    'NCTC 8325 / PS 47' 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Staphylococcus aureus subsp. aureus NCTC 8325' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     93061 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACO non-polymer         . 'ACETYL COENZYME *A' ? 'C23 H38 N7 O17 P3 S' 809.571 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'          133.103 
CIT non-polymer         . 'CITRIC ACID'        ? 'C6 H8 O7'            192.124 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE            ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER                ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'          119.119 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'         117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -9  ?   ?   ?   A . n 
A 1 2   GLY 2   -8  ?   ?   ?   A . n 
A 1 3   HIS 3   -7  ?   ?   ?   A . n 
A 1 4   HIS 4   -6  ?   ?   ?   A . n 
A 1 5   HIS 5   -5  ?   ?   ?   A . n 
A 1 6   HIS 6   -4  ?   ?   ?   A . n 
A 1 7   HIS 7   -3  ?   ?   ?   A . n 
A 1 8   HIS 8   -2  ?   ?   ?   A . n 
A 1 9   GLY 9   -1  ?   ?   ?   A . n 
A 1 10  SER 10  0   ?   ?   ?   A . n 
A 1 11  MET 11  1   ?   ?   ?   A . n 
A 1 12  ARG 12  2   2   ARG ARG A . n 
A 1 13  ARG 13  3   3   ARG ARG A . n 
A 1 14  HIS 14  4   4   HIS HIS A . n 
A 1 15  ALA 15  5   5   ALA ALA A . n 
A 1 16  ILE 16  6   6   ILE ILE A . n 
A 1 17  ILE 17  7   7   ILE ILE A . n 
A 1 18  LEU 18  8   8   LEU LEU A . n 
A 1 19  ALA 19  9   9   ALA ALA A . n 
A 1 20  ALA 20  10  10  ALA ALA A . n 
A 1 21  GLY 21  11  11  GLY GLY A . n 
A 1 22  LYS 22  12  12  LYS LYS A . n 
A 1 23  GLY 23  13  13  GLY GLY A . n 
A 1 24  THR 24  14  14  THR THR A . n 
A 1 25  ARG 25  15  15  ARG ARG A . n 
A 1 26  MET 26  16  16  MET MET A . n 
A 1 27  LYS 27  17  17  LYS LYS A . n 
A 1 28  SER 28  18  18  SER SER A . n 
A 1 29  LYS 29  19  19  LYS LYS A . n 
A 1 30  LYS 30  20  20  LYS LYS A . n 
A 1 31  TYR 31  21  21  TYR TYR A . n 
A 1 32  LYS 32  22  22  LYS LYS A . n 
A 1 33  VAL 33  23  23  VAL VAL A . n 
A 1 34  LEU 34  24  24  LEU LEU A . n 
A 1 35  HIS 35  25  25  HIS HIS A . n 
A 1 36  GLU 36  26  26  GLU GLU A . n 
A 1 37  VAL 37  27  27  VAL VAL A . n 
A 1 38  ALA 38  28  28  ALA ALA A . n 
A 1 39  GLY 39  29  29  GLY GLY A . n 
A 1 40  LYS 40  30  30  LYS LYS A . n 
A 1 41  PRO 41  31  31  PRO PRO A . n 
A 1 42  MET 42  32  32  MET MET A . n 
A 1 43  VAL 43  33  33  VAL VAL A . n 
A 1 44  GLU 44  34  34  GLU GLU A . n 
A 1 45  HIS 45  35  35  HIS HIS A . n 
A 1 46  VAL 46  36  36  VAL VAL A . n 
A 1 47  LEU 47  37  37  LEU LEU A . n 
A 1 48  GLU 48  38  38  GLU GLU A . n 
A 1 49  SER 49  39  39  SER SER A . n 
A 1 50  VAL 50  40  40  VAL VAL A . n 
A 1 51  LYS 51  41  41  LYS LYS A . n 
A 1 52  GLY 52  42  42  GLY GLY A . n 
A 1 53  SER 53  43  43  SER SER A . n 
A 1 54  GLY 54  44  44  GLY GLY A . n 
A 1 55  VAL 55  45  45  VAL VAL A . n 
A 1 56  ASP 56  46  46  ASP ASP A . n 
A 1 57  GLN 57  47  47  GLN GLN A . n 
A 1 58  VAL 58  48  48  VAL VAL A . n 
A 1 59  VAL 59  49  49  VAL VAL A . n 
A 1 60  THR 60  50  50  THR THR A . n 
A 1 61  ILE 61  51  51  ILE ILE A . n 
A 1 62  VAL 62  52  52  VAL VAL A . n 
A 1 63  GLY 63  53  53  GLY GLY A . n 
A 1 64  HIS 64  54  54  HIS HIS A . n 
A 1 65  GLY 65  55  55  GLY GLY A . n 
A 1 66  ALA 66  56  56  ALA ALA A . n 
A 1 67  GLU 67  57  57  GLU GLU A . n 
A 1 68  SER 68  58  58  SER SER A . n 
A 1 69  VAL 69  59  59  VAL VAL A . n 
A 1 70  LYS 70  60  60  LYS LYS A . n 
A 1 71  GLY 71  61  61  GLY GLY A . n 
A 1 72  HIS 72  62  62  HIS HIS A . n 
A 1 73  LEU 73  63  63  LEU LEU A . n 
A 1 74  GLY 74  64  64  GLY GLY A . n 
A 1 75  GLU 75  65  65  GLU GLU A . n 
A 1 76  ARG 76  66  66  ARG ARG A . n 
A 1 77  SER 77  67  67  SER SER A . n 
A 1 78  LEU 78  68  68  LEU LEU A . n 
A 1 79  TYR 79  69  69  TYR TYR A . n 
A 1 80  SER 80  70  70  SER SER A . n 
A 1 81  PHE 81  71  71  PHE PHE A . n 
A 1 82  GLN 82  72  72  GLN GLN A . n 
A 1 83  GLU 83  73  73  GLU GLU A . n 
A 1 84  GLU 84  74  74  GLU GLU A . n 
A 1 85  GLN 85  75  75  GLN GLN A . n 
A 1 86  LEU 86  76  76  LEU LEU A . n 
A 1 87  GLY 87  77  77  GLY GLY A . n 
A 1 88  THR 88  78  78  THR THR A . n 
A 1 89  ALA 89  79  79  ALA ALA A . n 
A 1 90  HIS 90  80  80  HIS HIS A . n 
A 1 91  ALA 91  81  81  ALA ALA A . n 
A 1 92  VAL 92  82  82  VAL VAL A . n 
A 1 93  GLN 93  83  83  GLN GLN A . n 
A 1 94  MET 94  84  84  MET MET A . n 
A 1 95  ALA 95  85  85  ALA ALA A . n 
A 1 96  LYS 96  86  86  LYS LYS A . n 
A 1 97  SER 97  87  87  SER SER A . n 
A 1 98  HIS 98  88  88  HIS HIS A . n 
A 1 99  LEU 99  89  89  LEU LEU A . n 
A 1 100 GLU 100 90  90  GLU GLU A . n 
A 1 101 ASP 101 91  91  ASP ASP A . n 
A 1 102 LYS 102 92  92  LYS LYS A . n 
A 1 103 GLU 103 93  93  GLU GLU A . n 
A 1 104 GLY 104 94  94  GLY GLY A . n 
A 1 105 THR 105 95  95  THR THR A . n 
A 1 106 THR 106 96  96  THR THR A . n 
A 1 107 ILE 107 97  97  ILE ILE A . n 
A 1 108 VAL 108 98  98  VAL VAL A . n 
A 1 109 VAL 109 99  99  VAL VAL A . n 
A 1 110 CYS 110 100 100 CYS CYS A . n 
A 1 111 GLY 111 101 101 GLY GLY A . n 
A 1 112 ASP 112 102 102 ASP ASP A . n 
A 1 113 THR 113 103 103 THR THR A . n 
A 1 114 PRO 114 104 104 PRO PRO A . n 
A 1 115 LEU 115 105 105 LEU LEU A . n 
A 1 116 ILE 116 106 106 ILE ILE A . n 
A 1 117 THR 117 107 107 THR THR A . n 
A 1 118 LYS 118 108 108 LYS LYS A . n 
A 1 119 GLU 119 109 109 GLU GLU A . n 
A 1 120 THR 120 110 110 THR THR A . n 
A 1 121 LEU 121 111 111 LEU LEU A . n 
A 1 122 VAL 122 112 112 VAL VAL A . n 
A 1 123 THR 123 113 113 THR THR A . n 
A 1 124 LEU 124 114 114 LEU LEU A . n 
A 1 125 ILE 125 115 115 ILE ILE A . n 
A 1 126 ALA 126 116 116 ALA ALA A . n 
A 1 127 HIS 127 117 117 HIS HIS A . n 
A 1 128 HIS 128 118 118 HIS HIS A . n 
A 1 129 GLU 129 119 119 GLU GLU A . n 
A 1 130 ASP 130 120 120 ASP ASP A . n 
A 1 131 ALA 131 121 121 ALA ALA A . n 
A 1 132 ASN 132 122 122 ASN ASN A . n 
A 1 133 ALA 133 123 123 ALA ALA A . n 
A 1 134 GLN 134 124 124 GLN GLN A . n 
A 1 135 ALA 135 125 125 ALA ALA A . n 
A 1 136 THR 136 126 126 THR THR A . n 
A 1 137 VAL 137 127 127 VAL VAL A . n 
A 1 138 LEU 138 128 128 LEU LEU A . n 
A 1 139 SER 139 129 129 SER SER A . n 
A 1 140 ALA 140 130 130 ALA ALA A . n 
A 1 141 SER 141 131 131 SER SER A . n 
A 1 142 ILE 142 132 132 ILE ILE A . n 
A 1 143 GLN 143 133 133 GLN GLN A . n 
A 1 144 GLN 144 134 134 GLN GLN A . n 
A 1 145 PRO 145 135 135 PRO PRO A . n 
A 1 146 TYR 146 136 136 TYR TYR A . n 
A 1 147 GLY 147 137 137 GLY GLY A . n 
A 1 148 TYR 148 138 138 TYR TYR A . n 
A 1 149 GLY 149 139 139 GLY GLY A . n 
A 1 150 ARG 150 140 140 ARG ARG A . n 
A 1 151 ILE 151 141 141 ILE ILE A . n 
A 1 152 VAL 152 142 142 VAL VAL A . n 
A 1 153 ARG 153 143 143 ARG ARG A . n 
A 1 154 ASN 154 144 144 ASN ASN A . n 
A 1 155 ALA 155 145 145 ALA ALA A . n 
A 1 156 SER 156 146 146 SER SER A . n 
A 1 157 GLY 157 147 147 GLY GLY A . n 
A 1 158 ARG 158 148 148 ARG ARG A . n 
A 1 159 LEU 159 149 149 LEU LEU A . n 
A 1 160 GLU 160 150 150 GLU GLU A . n 
A 1 161 ARG 161 151 151 ARG ARG A . n 
A 1 162 ILE 162 152 152 ILE ILE A . n 
A 1 163 VAL 163 153 153 VAL VAL A . n 
A 1 164 GLU 164 154 154 GLU GLU A . n 
A 1 165 GLU 165 155 155 GLU GLU A . n 
A 1 166 LYS 166 156 156 LYS LYS A . n 
A 1 167 ASP 167 157 157 ASP ASP A . n 
A 1 168 ALA 168 158 158 ALA ALA A . n 
A 1 169 THR 169 159 159 THR THR A . n 
A 1 170 GLN 170 160 160 GLN GLN A . n 
A 1 171 ALA 171 161 161 ALA ALA A . n 
A 1 172 GLU 172 162 162 GLU GLU A . n 
A 1 173 LYS 173 163 163 LYS LYS A . n 
A 1 174 ASP 174 164 164 ASP ASP A . n 
A 1 175 ILE 175 165 165 ILE ILE A . n 
A 1 176 ASN 176 166 166 ASN ASN A . n 
A 1 177 GLU 177 167 167 GLU GLU A . n 
A 1 178 ILE 178 168 168 ILE ILE A . n 
A 1 179 SER 179 169 169 SER SER A . n 
A 1 180 SER 180 170 170 SER SER A . n 
A 1 181 GLY 181 171 171 GLY GLY A . n 
A 1 182 ILE 182 172 172 ILE ILE A . n 
A 1 183 PHE 183 173 173 PHE PHE A . n 
A 1 184 ALA 184 174 174 ALA ALA A . n 
A 1 185 PHE 185 175 175 PHE PHE A . n 
A 1 186 ASN 186 176 176 ASN ASN A . n 
A 1 187 ASN 187 177 177 ASN ASN A . n 
A 1 188 LYS 188 178 178 LYS LYS A . n 
A 1 189 THR 189 179 179 THR THR A . n 
A 1 190 LEU 190 180 180 LEU LEU A . n 
A 1 191 PHE 191 181 181 PHE PHE A . n 
A 1 192 GLU 192 182 182 GLU GLU A . n 
A 1 193 LYS 193 183 183 LYS LYS A . n 
A 1 194 LEU 194 184 184 LEU LEU A . n 
A 1 195 THR 195 185 185 THR THR A . n 
A 1 196 GLN 196 186 186 GLN GLN A . n 
A 1 197 VAL 197 187 187 VAL VAL A . n 
A 1 198 LYS 198 188 188 LYS LYS A . n 
A 1 199 ASN 199 189 189 ASN ASN A . n 
A 1 200 ASP 200 190 190 ASP ASP A . n 
A 1 201 ASN 201 191 191 ASN ASN A . n 
A 1 202 ALA 202 192 192 ALA ALA A . n 
A 1 203 GLN 203 193 193 GLN GLN A . n 
A 1 204 GLY 204 194 194 GLY GLY A . n 
A 1 205 GLU 205 195 195 GLU GLU A . n 
A 1 206 TYR 206 196 196 TYR TYR A . n 
A 1 207 TYR 207 197 197 TYR TYR A . n 
A 1 208 LEU 208 198 198 LEU LEU A . n 
A 1 209 PRO 209 199 199 PRO PRO A . n 
A 1 210 ASP 210 200 200 ASP ASP A . n 
A 1 211 VAL 211 201 201 VAL VAL A . n 
A 1 212 LEU 212 202 202 LEU LEU A . n 
A 1 213 SER 213 203 203 SER SER A . n 
A 1 214 LEU 214 204 204 LEU LEU A . n 
A 1 215 ILE 215 205 205 ILE ILE A . n 
A 1 216 LEU 216 206 206 LEU LEU A . n 
A 1 217 ASN 217 207 207 ASN ASN A . n 
A 1 218 ASP 218 208 208 ASP ASP A . n 
A 1 219 GLY 219 209 209 GLY GLY A . n 
A 1 220 GLY 220 210 210 GLY GLY A . n 
A 1 221 ILE 221 211 211 ILE ILE A . n 
A 1 222 VAL 222 212 212 VAL VAL A . n 
A 1 223 GLU 223 213 213 GLU GLU A . n 
A 1 224 VAL 224 214 214 VAL VAL A . n 
A 1 225 TYR 225 215 215 TYR TYR A . n 
A 1 226 ARG 226 216 216 ARG ARG A . n 
A 1 227 THR 227 217 217 THR THR A . n 
A 1 228 ASN 228 218 218 ASN ASN A . n 
A 1 229 ASP 229 219 219 ASP ASP A . n 
A 1 230 VAL 230 220 220 VAL VAL A . n 
A 1 231 GLU 231 221 221 GLU GLU A . n 
A 1 232 GLU 232 222 222 GLU GLU A . n 
A 1 233 ILE 233 223 223 ILE ILE A . n 
A 1 234 MET 234 224 224 MET MET A . n 
A 1 235 GLY 235 225 225 GLY GLY A . n 
A 1 236 VAL 236 226 226 VAL VAL A . n 
A 1 237 ASN 237 227 227 ASN ASN A . n 
A 1 238 ASP 238 228 228 ASP ASP A . n 
A 1 239 ARG 239 229 229 ARG ARG A . n 
A 1 240 VAL 240 230 230 VAL VAL A . n 
A 1 241 MET 241 231 231 MET MET A . n 
A 1 242 LEU 242 232 232 LEU LEU A . n 
A 1 243 SER 243 233 233 SER SER A . n 
A 1 244 GLN 244 234 234 GLN GLN A . n 
A 1 245 ALA 245 235 235 ALA ALA A . n 
A 1 246 GLU 246 236 236 GLU GLU A . n 
A 1 247 LYS 247 237 237 LYS LYS A . n 
A 1 248 ALA 248 238 238 ALA ALA A . n 
A 1 249 MET 249 239 239 MET MET A . n 
A 1 250 GLN 250 240 240 GLN GLN A . n 
A 1 251 ARG 251 241 241 ARG ARG A . n 
A 1 252 ARG 252 242 242 ARG ARG A . n 
A 1 253 THR 253 243 243 THR THR A . n 
A 1 254 ASN 254 244 244 ASN ASN A . n 
A 1 255 HIS 255 245 245 HIS HIS A . n 
A 1 256 TYR 256 246 246 TYR TYR A . n 
A 1 257 HIS 257 247 247 HIS HIS A . n 
A 1 258 MET 258 248 248 MET MET A . n 
A 1 259 LEU 259 249 249 LEU LEU A . n 
A 1 260 ASN 260 250 250 ASN ASN A . n 
A 1 261 GLY 261 251 251 GLY GLY A . n 
A 1 262 VAL 262 252 252 VAL VAL A . n 
A 1 263 THR 263 253 253 THR THR A . n 
A 1 264 ILE 264 254 254 ILE ILE A . n 
A 1 265 ILE 265 255 255 ILE ILE A . n 
A 1 266 ASP 266 256 256 ASP ASP A . n 
A 1 267 PRO 267 257 257 PRO PRO A . n 
A 1 268 ASP 268 258 258 ASP ASP A . n 
A 1 269 SER 269 259 259 SER SER A . n 
A 1 270 THR 270 260 260 THR THR A . n 
A 1 271 TYR 271 261 261 TYR TYR A . n 
A 1 272 ILE 272 262 262 ILE ILE A . n 
A 1 273 GLY 273 263 263 GLY GLY A . n 
A 1 274 PRO 274 264 264 PRO PRO A . n 
A 1 275 ASP 275 265 265 ASP ASP A . n 
A 1 276 VAL 276 266 266 VAL VAL A . n 
A 1 277 THR 277 267 267 THR THR A . n 
A 1 278 ILE 278 268 268 ILE ILE A . n 
A 1 279 GLY 279 269 269 GLY GLY A . n 
A 1 280 SER 280 270 270 SER SER A . n 
A 1 281 ASP 281 271 271 ASP ASP A . n 
A 1 282 THR 282 272 272 THR THR A . n 
A 1 283 VAL 283 273 273 VAL VAL A . n 
A 1 284 ILE 284 274 274 ILE ILE A . n 
A 1 285 GLU 285 275 275 GLU GLU A . n 
A 1 286 PRO 286 276 276 PRO PRO A . n 
A 1 287 GLY 287 277 277 GLY GLY A . n 
A 1 288 VAL 288 278 278 VAL VAL A . n 
A 1 289 ARG 289 279 279 ARG ARG A . n 
A 1 290 ILE 290 280 280 ILE ILE A . n 
A 1 291 ASN 291 281 281 ASN ASN A . n 
A 1 292 GLY 292 282 282 GLY GLY A . n 
A 1 293 ARG 293 283 283 ARG ARG A . n 
A 1 294 THR 294 284 284 THR THR A . n 
A 1 295 GLU 295 285 285 GLU GLU A . n 
A 1 296 ILE 296 286 286 ILE ILE A . n 
A 1 297 GLY 297 287 287 GLY GLY A . n 
A 1 298 GLU 298 288 288 GLU GLU A . n 
A 1 299 ASP 299 289 289 ASP ASP A . n 
A 1 300 VAL 300 290 290 VAL VAL A . n 
A 1 301 VAL 301 291 291 VAL VAL A . n 
A 1 302 ILE 302 292 292 ILE ILE A . n 
A 1 303 GLY 303 293 293 GLY GLY A . n 
A 1 304 GLN 304 294 294 GLN GLN A . n 
A 1 305 TYR 305 295 295 TYR TYR A . n 
A 1 306 SER 306 296 296 SER SER A . n 
A 1 307 GLU 307 297 297 GLU GLU A . n 
A 1 308 ILE 308 298 298 ILE ILE A . n 
A 1 309 ASN 309 299 299 ASN ASN A . n 
A 1 310 ASN 310 300 300 ASN ASN A . n 
A 1 311 SER 311 301 301 SER SER A . n 
A 1 312 THR 312 302 302 THR THR A . n 
A 1 313 ILE 313 303 303 ILE ILE A . n 
A 1 314 GLU 314 304 304 GLU GLU A . n 
A 1 315 ASN 315 305 305 ASN ASN A . n 
A 1 316 GLY 316 306 306 GLY GLY A . n 
A 1 317 ALA 317 307 307 ALA ALA A . n 
A 1 318 CYS 318 308 308 CYS CYS A . n 
A 1 319 ILE 319 309 309 ILE ILE A . n 
A 1 320 GLN 320 310 310 GLN GLN A . n 
A 1 321 GLN 321 311 311 GLN GLN A . n 
A 1 322 SER 322 312 312 SER SER A . n 
A 1 323 VAL 323 313 313 VAL VAL A . n 
A 1 324 VAL 324 314 314 VAL VAL A . n 
A 1 325 ASN 325 315 315 ASN ASN A . n 
A 1 326 ASP 326 316 316 ASP ASP A . n 
A 1 327 ALA 327 317 317 ALA ALA A . n 
A 1 328 SER 328 318 318 SER SER A . n 
A 1 329 VAL 329 319 319 VAL VAL A . n 
A 1 330 GLY 330 320 320 GLY GLY A . n 
A 1 331 ALA 331 321 321 ALA ALA A . n 
A 1 332 ASN 332 322 322 ASN ASN A . n 
A 1 333 THR 333 323 323 THR THR A . n 
A 1 334 LYS 334 324 324 LYS LYS A . n 
A 1 335 VAL 335 325 325 VAL VAL A . n 
A 1 336 GLY 336 326 326 GLY GLY A . n 
A 1 337 PRO 337 327 327 PRO PRO A . n 
A 1 338 PHE 338 328 328 PHE PHE A . n 
A 1 339 ALA 339 329 329 ALA ALA A . n 
A 1 340 GLN 340 330 330 GLN GLN A . n 
A 1 341 LEU 341 331 331 LEU LEU A . n 
A 1 342 ARG 342 332 332 ARG ARG A . n 
A 1 343 PRO 343 333 333 PRO PRO A . n 
A 1 344 GLY 344 334 334 GLY GLY A . n 
A 1 345 ALA 345 335 335 ALA ALA A . n 
A 1 346 GLN 346 336 336 GLN GLN A . n 
A 1 347 LEU 347 337 337 LEU LEU A . n 
A 1 348 GLY 348 338 338 GLY GLY A . n 
A 1 349 ALA 349 339 339 ALA ALA A . n 
A 1 350 ASP 350 340 340 ASP ASP A . n 
A 1 351 VAL 351 341 341 VAL VAL A . n 
A 1 352 LYS 352 342 342 LYS LYS A . n 
A 1 353 VAL 353 343 343 VAL VAL A . n 
A 1 354 GLY 354 344 344 GLY GLY A . n 
A 1 355 ASN 355 345 345 ASN ASN A . n 
A 1 356 PHE 356 346 346 PHE PHE A . n 
A 1 357 VAL 357 347 347 VAL VAL A . n 
A 1 358 GLU 358 348 348 GLU GLU A . n 
A 1 359 ILE 359 349 349 ILE ILE A . n 
A 1 360 LYS 360 350 350 LYS LYS A . n 
A 1 361 LYS 361 351 351 LYS LYS A . n 
A 1 362 ALA 362 352 352 ALA ALA A . n 
A 1 363 ASP 363 353 353 ASP ASP A . n 
A 1 364 LEU 364 354 354 LEU LEU A . n 
A 1 365 LYS 365 355 355 LYS LYS A . n 
A 1 366 ASP 366 356 356 ASP ASP A . n 
A 1 367 GLY 367 357 357 GLY GLY A . n 
A 1 368 ALA 368 358 358 ALA ALA A . n 
A 1 369 LYS 369 359 359 LYS LYS A . n 
A 1 370 VAL 370 360 360 VAL VAL A . n 
A 1 371 SER 371 361 361 SER SER A . n 
A 1 372 HIS 372 362 362 HIS HIS A . n 
A 1 373 LEU 373 363 363 LEU LEU A . n 
A 1 374 SER 374 364 364 SER SER A . n 
A 1 375 TYR 375 365 365 TYR TYR A . n 
A 1 376 ILE 376 366 366 ILE ILE A . n 
A 1 377 GLY 377 367 367 GLY GLY A . n 
A 1 378 ASP 378 368 368 ASP ASP A . n 
A 1 379 ALA 379 369 369 ALA ALA A . n 
A 1 380 VAL 380 370 370 VAL VAL A . n 
A 1 381 ILE 381 371 371 ILE ILE A . n 
A 1 382 GLY 382 372 372 GLY GLY A . n 
A 1 383 GLU 383 373 373 GLU GLU A . n 
A 1 384 ARG 384 374 374 ARG ARG A . n 
A 1 385 THR 385 375 375 THR THR A . n 
A 1 386 ASN 386 376 376 ASN ASN A . n 
A 1 387 ILE 387 377 377 ILE ILE A . n 
A 1 388 GLY 388 378 378 GLY GLY A . n 
A 1 389 CYS 389 379 379 CYS CYS A . n 
A 1 390 GLY 390 380 380 GLY GLY A . n 
A 1 391 THR 391 381 381 THR THR A . n 
A 1 392 ILE 392 382 382 ILE ILE A . n 
A 1 393 THR 393 383 383 THR THR A . n 
A 1 394 VAL 394 384 384 VAL VAL A . n 
A 1 395 ASN 395 385 385 ASN ASN A . n 
A 1 396 TYR 396 386 386 TYR TYR A . n 
A 1 397 ASP 397 387 387 ASP ASP A . n 
A 1 398 GLY 398 388 388 GLY GLY A . n 
A 1 399 GLU 399 389 389 GLU GLU A . n 
A 1 400 ASN 400 390 390 ASN ASN A . n 
A 1 401 LYS 401 391 391 LYS LYS A . n 
A 1 402 PHE 402 392 392 PHE PHE A . n 
A 1 403 LYS 403 393 393 LYS LYS A . n 
A 1 404 THR 404 394 394 THR THR A . n 
A 1 405 ILE 405 395 395 ILE ILE A . n 
A 1 406 VAL 406 396 396 VAL VAL A . n 
A 1 407 GLY 407 397 397 GLY GLY A . n 
A 1 408 LYS 408 398 398 LYS LYS A . n 
A 1 409 ASP 409 399 399 ASP ASP A . n 
A 1 410 SER 410 400 400 SER SER A . n 
A 1 411 PHE 411 401 401 PHE PHE A . n 
A 1 412 VAL 412 402 402 VAL VAL A . n 
A 1 413 GLY 413 403 403 GLY GLY A . n 
A 1 414 CYS 414 404 404 CYS CYS A . n 
A 1 415 ASN 415 405 405 ASN ASN A . n 
A 1 416 VAL 416 406 406 VAL VAL A . n 
A 1 417 ASN 417 407 407 ASN ASN A . n 
A 1 418 LEU 418 408 408 LEU LEU A . n 
A 1 419 VAL 419 409 409 VAL VAL A . n 
A 1 420 ALA 420 410 410 ALA ALA A . n 
A 1 421 PRO 421 411 411 PRO PRO A . n 
A 1 422 VAL 422 412 412 VAL VAL A . n 
A 1 423 THR 423 413 413 THR THR A . n 
A 1 424 ILE 424 414 414 ILE ILE A . n 
A 1 425 GLY 425 415 415 GLY GLY A . n 
A 1 426 ASP 426 416 416 ASP ASP A . n 
A 1 427 ASP 427 417 417 ASP ASP A . n 
A 1 428 VAL 428 418 418 VAL VAL A . n 
A 1 429 LEU 429 419 419 LEU LEU A . n 
A 1 430 VAL 430 420 420 VAL VAL A . n 
A 1 431 ALA 431 421 421 ALA ALA A . n 
A 1 432 ALA 432 422 422 ALA ALA A . n 
A 1 433 GLY 433 423 423 GLY GLY A . n 
A 1 434 SER 434 424 424 SER SER A . n 
A 1 435 THR 435 425 425 THR THR A . n 
A 1 436 ILE 436 426 426 ILE ILE A . n 
A 1 437 THR 437 427 427 THR THR A . n 
A 1 438 ASP 438 428 428 ASP ASP A . n 
A 1 439 ASP 439 429 429 ASP ASP A . n 
A 1 440 VAL 440 430 430 VAL VAL A . n 
A 1 441 PRO 441 431 431 PRO PRO A . n 
A 1 442 ASN 442 432 432 ASN ASN A . n 
A 1 443 ASP 443 433 433 ASP ASP A . n 
A 1 444 SER 444 434 434 SER SER A . n 
A 1 445 LEU 445 435 435 LEU LEU A . n 
A 1 446 ALA 446 436 436 ALA ALA A . n 
A 1 447 VAL 447 437 437 VAL VAL A . n 
A 1 448 ALA 448 438 438 ALA ALA A . n 
A 1 449 ARG 449 439 439 ARG ARG A . n 
A 1 450 ALA 450 440 440 ALA ALA A . n 
A 1 451 ARG 451 441 441 ARG ARG A . n 
A 1 452 GLN 452 442 442 GLN GLN A . n 
A 1 453 THR 453 443 443 THR THR A . n 
A 1 454 THR 454 444 444 THR THR A . n 
A 1 455 LYS 455 445 445 LYS LYS A . n 
A 1 456 GLU 456 446 446 GLU GLU A . n 
A 1 457 GLY 457 447 447 GLY GLY A . n 
A 1 458 TYR 458 448 448 TYR TYR A . n 
A 1 459 ARG 459 449 449 ARG ARG A . n 
A 1 460 LYS 460 450 450 LYS LYS A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ACO 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ACO 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ACO 1   501 1   ACO ACO A . 
C 3 CIT 1   502 1   CIT CIT A . 
D 4 HOH 1   601 138 HOH HOH A . 
D 4 HOH 2   602 143 HOH HOH A . 
D 4 HOH 3   603 200 HOH HOH A . 
D 4 HOH 4   604 164 HOH HOH A . 
D 4 HOH 5   605 179 HOH HOH A . 
D 4 HOH 6   606 142 HOH HOH A . 
D 4 HOH 7   607 60  HOH HOH A . 
D 4 HOH 8   608 97  HOH HOH A . 
D 4 HOH 9   609 175 HOH HOH A . 
D 4 HOH 10  610 96  HOH HOH A . 
D 4 HOH 11  611 51  HOH HOH A . 
D 4 HOH 12  612 28  HOH HOH A . 
D 4 HOH 13  613 57  HOH HOH A . 
D 4 HOH 14  614 90  HOH HOH A . 
D 4 HOH 15  615 159 HOH HOH A . 
D 4 HOH 16  616 192 HOH HOH A . 
D 4 HOH 17  617 100 HOH HOH A . 
D 4 HOH 18  618 15  HOH HOH A . 
D 4 HOH 19  619 16  HOH HOH A . 
D 4 HOH 20  620 130 HOH HOH A . 
D 4 HOH 21  621 73  HOH HOH A . 
D 4 HOH 22  622 129 HOH HOH A . 
D 4 HOH 23  623 13  HOH HOH A . 
D 4 HOH 24  624 154 HOH HOH A . 
D 4 HOH 25  625 48  HOH HOH A . 
D 4 HOH 26  626 111 HOH HOH A . 
D 4 HOH 27  627 63  HOH HOH A . 
D 4 HOH 28  628 1   HOH HOH A . 
D 4 HOH 29  629 89  HOH HOH A . 
D 4 HOH 30  630 54  HOH HOH A . 
D 4 HOH 31  631 46  HOH HOH A . 
D 4 HOH 32  632 29  HOH HOH A . 
D 4 HOH 33  633 124 HOH HOH A . 
D 4 HOH 34  634 91  HOH HOH A . 
D 4 HOH 35  635 24  HOH HOH A . 
D 4 HOH 36  636 12  HOH HOH A . 
D 4 HOH 37  637 116 HOH HOH A . 
D 4 HOH 38  638 81  HOH HOH A . 
D 4 HOH 39  639 85  HOH HOH A . 
D 4 HOH 40  640 68  HOH HOH A . 
D 4 HOH 41  641 56  HOH HOH A . 
D 4 HOH 42  642 121 HOH HOH A . 
D 4 HOH 43  643 9   HOH HOH A . 
D 4 HOH 44  644 42  HOH HOH A . 
D 4 HOH 45  645 110 HOH HOH A . 
D 4 HOH 46  646 20  HOH HOH A . 
D 4 HOH 47  647 147 HOH HOH A . 
D 4 HOH 48  648 191 HOH HOH A . 
D 4 HOH 49  649 62  HOH HOH A . 
D 4 HOH 50  650 156 HOH HOH A . 
D 4 HOH 51  651 47  HOH HOH A . 
D 4 HOH 52  652 6   HOH HOH A . 
D 4 HOH 53  653 4   HOH HOH A . 
D 4 HOH 54  654 34  HOH HOH A . 
D 4 HOH 55  655 21  HOH HOH A . 
D 4 HOH 56  656 3   HOH HOH A . 
D 4 HOH 57  657 27  HOH HOH A . 
D 4 HOH 58  658 104 HOH HOH A . 
D 4 HOH 59  659 167 HOH HOH A . 
D 4 HOH 60  660 49  HOH HOH A . 
D 4 HOH 61  661 197 HOH HOH A . 
D 4 HOH 62  662 74  HOH HOH A . 
D 4 HOH 63  663 11  HOH HOH A . 
D 4 HOH 64  664 66  HOH HOH A . 
D 4 HOH 65  665 2   HOH HOH A . 
D 4 HOH 66  666 23  HOH HOH A . 
D 4 HOH 67  667 199 HOH HOH A . 
D 4 HOH 68  668 22  HOH HOH A . 
D 4 HOH 69  669 88  HOH HOH A . 
D 4 HOH 70  670 160 HOH HOH A . 
D 4 HOH 71  671 139 HOH HOH A . 
D 4 HOH 72  672 108 HOH HOH A . 
D 4 HOH 73  673 101 HOH HOH A . 
D 4 HOH 74  674 155 HOH HOH A . 
D 4 HOH 75  675 72  HOH HOH A . 
D 4 HOH 76  676 32  HOH HOH A . 
D 4 HOH 77  677 125 HOH HOH A . 
D 4 HOH 78  678 77  HOH HOH A . 
D 4 HOH 79  679 162 HOH HOH A . 
D 4 HOH 80  680 127 HOH HOH A . 
D 4 HOH 81  681 95  HOH HOH A . 
D 4 HOH 82  682 14  HOH HOH A . 
D 4 HOH 83  683 17  HOH HOH A . 
D 4 HOH 84  684 40  HOH HOH A . 
D 4 HOH 85  685 37  HOH HOH A . 
D 4 HOH 86  686 157 HOH HOH A . 
D 4 HOH 87  687 50  HOH HOH A . 
D 4 HOH 88  688 194 HOH HOH A . 
D 4 HOH 89  689 181 HOH HOH A . 
D 4 HOH 90  690 169 HOH HOH A . 
D 4 HOH 91  691 58  HOH HOH A . 
D 4 HOH 92  692 113 HOH HOH A . 
D 4 HOH 93  693 93  HOH HOH A . 
D 4 HOH 94  694 8   HOH HOH A . 
D 4 HOH 95  695 141 HOH HOH A . 
D 4 HOH 96  696 148 HOH HOH A . 
D 4 HOH 97  697 65  HOH HOH A . 
D 4 HOH 98  698 44  HOH HOH A . 
D 4 HOH 99  699 43  HOH HOH A . 
D 4 HOH 100 700 112 HOH HOH A . 
D 4 HOH 101 701 67  HOH HOH A . 
D 4 HOH 102 702 183 HOH HOH A . 
D 4 HOH 103 703 7   HOH HOH A . 
D 4 HOH 104 704 10  HOH HOH A . 
D 4 HOH 105 705 69  HOH HOH A . 
D 4 HOH 106 706 5   HOH HOH A . 
D 4 HOH 107 707 31  HOH HOH A . 
D 4 HOH 108 708 52  HOH HOH A . 
D 4 HOH 109 709 115 HOH HOH A . 
D 4 HOH 110 710 38  HOH HOH A . 
D 4 HOH 111 711 19  HOH HOH A . 
D 4 HOH 112 712 161 HOH HOH A . 
D 4 HOH 113 713 25  HOH HOH A . 
D 4 HOH 114 714 132 HOH HOH A . 
D 4 HOH 115 715 173 HOH HOH A . 
D 4 HOH 116 716 18  HOH HOH A . 
D 4 HOH 117 717 33  HOH HOH A . 
D 4 HOH 118 718 45  HOH HOH A . 
D 4 HOH 119 719 86  HOH HOH A . 
D 4 HOH 120 720 131 HOH HOH A . 
D 4 HOH 121 721 189 HOH HOH A . 
D 4 HOH 122 722 92  HOH HOH A . 
D 4 HOH 123 723 140 HOH HOH A . 
D 4 HOH 124 724 70  HOH HOH A . 
D 4 HOH 125 725 165 HOH HOH A . 
D 4 HOH 126 726 79  HOH HOH A . 
D 4 HOH 127 727 182 HOH HOH A . 
D 4 HOH 128 728 178 HOH HOH A . 
D 4 HOH 129 729 75  HOH HOH A . 
D 4 HOH 130 730 180 HOH HOH A . 
D 4 HOH 131 731 35  HOH HOH A . 
D 4 HOH 132 732 99  HOH HOH A . 
D 4 HOH 133 733 83  HOH HOH A . 
D 4 HOH 134 734 41  HOH HOH A . 
D 4 HOH 135 735 149 HOH HOH A . 
D 4 HOH 136 736 80  HOH HOH A . 
D 4 HOH 137 737 36  HOH HOH A . 
D 4 HOH 138 738 53  HOH HOH A . 
D 4 HOH 139 739 84  HOH HOH A . 
D 4 HOH 140 740 114 HOH HOH A . 
D 4 HOH 141 741 39  HOH HOH A . 
D 4 HOH 142 742 186 HOH HOH A . 
D 4 HOH 143 743 128 HOH HOH A . 
D 4 HOH 144 744 82  HOH HOH A . 
D 4 HOH 145 745 117 HOH HOH A . 
D 4 HOH 146 746 26  HOH HOH A . 
D 4 HOH 147 747 76  HOH HOH A . 
D 4 HOH 148 748 59  HOH HOH A . 
D 4 HOH 149 749 55  HOH HOH A . 
D 4 HOH 150 750 198 HOH HOH A . 
D 4 HOH 151 751 30  HOH HOH A . 
D 4 HOH 152 752 146 HOH HOH A . 
D 4 HOH 153 753 61  HOH HOH A . 
D 4 HOH 154 754 106 HOH HOH A . 
D 4 HOH 155 755 203 HOH HOH A . 
D 4 HOH 156 756 174 HOH HOH A . 
D 4 HOH 157 757 87  HOH HOH A . 
D 4 HOH 158 758 190 HOH HOH A . 
D 4 HOH 159 759 163 HOH HOH A . 
D 4 HOH 160 760 144 HOH HOH A . 
D 4 HOH 161 761 204 HOH HOH A . 
D 4 HOH 162 762 171 HOH HOH A . 
D 4 HOH 163 763 187 HOH HOH A . 
D 4 HOH 164 764 126 HOH HOH A . 
D 4 HOH 165 765 137 HOH HOH A . 
D 4 HOH 166 766 71  HOH HOH A . 
D 4 HOH 167 767 133 HOH HOH A . 
D 4 HOH 168 768 135 HOH HOH A . 
D 4 HOH 169 769 184 HOH HOH A . 
D 4 HOH 170 770 78  HOH HOH A . 
D 4 HOH 171 771 201 HOH HOH A . 
D 4 HOH 172 772 145 HOH HOH A . 
D 4 HOH 173 773 123 HOH HOH A . 
D 4 HOH 174 774 151 HOH HOH A . 
D 4 HOH 175 775 118 HOH HOH A . 
D 4 HOH 176 776 176 HOH HOH A . 
D 4 HOH 177 777 122 HOH HOH A . 
D 4 HOH 178 778 64  HOH HOH A . 
D 4 HOH 179 779 172 HOH HOH A . 
D 4 HOH 180 780 168 HOH HOH A . 
D 4 HOH 181 781 103 HOH HOH A . 
D 4 HOH 182 782 105 HOH HOH A . 
D 4 HOH 183 783 94  HOH HOH A . 
D 4 HOH 184 784 150 HOH HOH A . 
D 4 HOH 185 785 109 HOH HOH A . 
D 4 HOH 186 786 202 HOH HOH A . 
D 4 HOH 187 787 153 HOH HOH A . 
D 4 HOH 188 788 170 HOH HOH A . 
D 4 HOH 189 789 158 HOH HOH A . 
D 4 HOH 190 790 188 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ARG 2   ? CG  ? A ARG 12  CG  
2   1 Y 1 A ARG 2   ? CD  ? A ARG 12  CD  
3   1 Y 1 A ARG 2   ? NE  ? A ARG 12  NE  
4   1 Y 1 A ARG 2   ? CZ  ? A ARG 12  CZ  
5   1 Y 1 A ARG 2   ? NH1 ? A ARG 12  NH1 
6   1 Y 1 A ARG 2   ? NH2 ? A ARG 12  NH2 
7   1 Y 1 A LYS 12  ? CG  ? A LYS 22  CG  
8   1 Y 1 A LYS 12  ? CD  ? A LYS 22  CD  
9   1 Y 1 A LYS 12  ? CE  ? A LYS 22  CE  
10  1 Y 1 A LYS 12  ? NZ  ? A LYS 22  NZ  
11  1 Y 1 A LYS 19  ? CG  ? A LYS 29  CG  
12  1 Y 1 A LYS 19  ? CD  ? A LYS 29  CD  
13  1 Y 1 A LYS 19  ? CE  ? A LYS 29  CE  
14  1 Y 1 A LYS 19  ? NZ  ? A LYS 29  NZ  
15  1 Y 1 A LYS 20  ? CG  ? A LYS 30  CG  
16  1 Y 1 A LYS 20  ? CD  ? A LYS 30  CD  
17  1 Y 1 A LYS 20  ? CE  ? A LYS 30  CE  
18  1 Y 1 A LYS 20  ? NZ  ? A LYS 30  NZ  
19  1 Y 1 A ASP 46  ? CG  ? A ASP 56  CG  
20  1 Y 1 A ASP 46  ? OD1 ? A ASP 56  OD1 
21  1 Y 1 A ASP 46  ? OD2 ? A ASP 56  OD2 
22  1 Y 1 A GLN 75  ? CG  ? A GLN 85  CG  
23  1 Y 1 A GLN 75  ? CD  ? A GLN 85  CD  
24  1 Y 1 A GLN 75  ? OE1 ? A GLN 85  OE1 
25  1 Y 1 A GLN 75  ? NE2 ? A GLN 85  NE2 
26  1 Y 1 A LYS 92  ? CG  ? A LYS 102 CG  
27  1 Y 1 A LYS 92  ? CD  ? A LYS 102 CD  
28  1 Y 1 A LYS 92  ? CE  ? A LYS 102 CE  
29  1 Y 1 A LYS 92  ? NZ  ? A LYS 102 NZ  
30  1 Y 1 A ASN 122 ? CG  ? A ASN 132 CG  
31  1 Y 1 A ASN 122 ? OD1 ? A ASN 132 OD1 
32  1 Y 1 A ASN 122 ? ND2 ? A ASN 132 ND2 
33  1 Y 1 A ILE 132 ? CG1 ? A ILE 142 CG1 
34  1 Y 1 A ILE 132 ? CG2 ? A ILE 142 CG2 
35  1 Y 1 A ILE 132 ? CD1 ? A ILE 142 CD1 
36  1 Y 1 A GLN 133 ? CG  ? A GLN 143 CG  
37  1 Y 1 A GLN 133 ? CD  ? A GLN 143 CD  
38  1 Y 1 A GLN 133 ? OE1 ? A GLN 143 OE1 
39  1 Y 1 A GLN 133 ? NE2 ? A GLN 143 NE2 
40  1 Y 1 A GLN 134 ? CG  ? A GLN 144 CG  
41  1 Y 1 A GLN 134 ? CD  ? A GLN 144 CD  
42  1 Y 1 A GLN 134 ? OE1 ? A GLN 144 OE1 
43  1 Y 1 A GLN 134 ? NE2 ? A GLN 144 NE2 
44  1 Y 1 A TYR 138 ? CG  ? A TYR 148 CG  
45  1 Y 1 A TYR 138 ? CD1 ? A TYR 148 CD1 
46  1 Y 1 A TYR 138 ? CD2 ? A TYR 148 CD2 
47  1 Y 1 A TYR 138 ? CE1 ? A TYR 148 CE1 
48  1 Y 1 A TYR 138 ? CE2 ? A TYR 148 CE2 
49  1 Y 1 A TYR 138 ? CZ  ? A TYR 148 CZ  
50  1 Y 1 A TYR 138 ? OH  ? A TYR 148 OH  
51  1 Y 1 A LYS 156 ? CG  ? A LYS 166 CG  
52  1 Y 1 A LYS 156 ? CD  ? A LYS 166 CD  
53  1 Y 1 A LYS 156 ? CE  ? A LYS 166 CE  
54  1 Y 1 A LYS 156 ? NZ  ? A LYS 166 NZ  
55  1 Y 1 A ASP 157 ? CG  ? A ASP 167 CG  
56  1 Y 1 A ASP 157 ? OD1 ? A ASP 167 OD1 
57  1 Y 1 A ASP 157 ? OD2 ? A ASP 167 OD2 
58  1 Y 1 A GLN 160 ? CG  ? A GLN 170 CG  
59  1 Y 1 A GLN 160 ? CD  ? A GLN 170 CD  
60  1 Y 1 A GLN 160 ? OE1 ? A GLN 170 OE1 
61  1 Y 1 A GLN 160 ? NE2 ? A GLN 170 NE2 
62  1 Y 1 A LYS 178 ? CG  ? A LYS 188 CG  
63  1 Y 1 A LYS 178 ? CD  ? A LYS 188 CD  
64  1 Y 1 A LYS 178 ? CE  ? A LYS 188 CE  
65  1 Y 1 A LYS 178 ? NZ  ? A LYS 188 NZ  
66  1 Y 1 A LYS 188 ? CG  ? A LYS 198 CG  
67  1 Y 1 A LYS 188 ? CD  ? A LYS 198 CD  
68  1 Y 1 A LYS 188 ? CE  ? A LYS 198 CE  
69  1 Y 1 A LYS 188 ? NZ  ? A LYS 198 NZ  
70  1 Y 1 A ASP 190 ? CG  ? A ASP 200 CG  
71  1 Y 1 A ASP 190 ? OD1 ? A ASP 200 OD1 
72  1 Y 1 A ASP 190 ? OD2 ? A ASP 200 OD2 
73  1 Y 1 A GLN 193 ? CG  ? A GLN 203 CG  
74  1 Y 1 A GLN 193 ? CD  ? A GLN 203 CD  
75  1 Y 1 A GLN 193 ? OE1 ? A GLN 203 OE1 
76  1 Y 1 A GLN 193 ? NE2 ? A GLN 203 NE2 
77  1 Y 1 A ASN 218 ? CG  ? A ASN 228 CG  
78  1 Y 1 A ASN 218 ? OD1 ? A ASN 228 OD1 
79  1 Y 1 A ASN 218 ? ND2 ? A ASN 228 ND2 
80  1 Y 1 A ARG 283 ? CG  ? A ARG 293 CG  
81  1 Y 1 A ARG 283 ? CD  ? A ARG 293 CD  
82  1 Y 1 A ARG 283 ? NE  ? A ARG 293 NE  
83  1 Y 1 A ARG 283 ? CZ  ? A ARG 293 CZ  
84  1 Y 1 A ARG 283 ? NH1 ? A ARG 293 NH1 
85  1 Y 1 A ARG 283 ? NH2 ? A ARG 293 NH2 
86  1 Y 1 A LYS 351 ? CG  ? A LYS 361 CG  
87  1 Y 1 A LYS 351 ? CD  ? A LYS 361 CD  
88  1 Y 1 A LYS 351 ? CE  ? A LYS 361 CE  
89  1 Y 1 A LYS 351 ? NZ  ? A LYS 361 NZ  
90  1 Y 1 A LYS 359 ? CG  ? A LYS 369 CG  
91  1 Y 1 A LYS 359 ? CD  ? A LYS 369 CD  
92  1 Y 1 A LYS 359 ? CE  ? A LYS 369 CE  
93  1 Y 1 A LYS 359 ? NZ  ? A LYS 369 NZ  
94  1 Y 1 A LYS 393 ? CG  ? A LYS 403 CG  
95  1 Y 1 A LYS 393 ? CD  ? A LYS 403 CD  
96  1 Y 1 A LYS 393 ? CE  ? A LYS 403 CE  
97  1 Y 1 A LYS 393 ? NZ  ? A LYS 403 NZ  
98  1 Y 1 A LYS 450 ? CG  ? A LYS 460 CG  
99  1 Y 1 A LYS 450 ? CD  ? A LYS 460 CD  
100 1 Y 1 A LYS 450 ? CE  ? A LYS 460 CE  
101 1 Y 1 A LYS 450 ? NZ  ? A LYS 460 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? 0.7.4       2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? 2.8.3       4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     95.980 
_cell.length_a_esd                 ? 
_cell.length_b                     95.980 
_cell.length_b_esd                 ? 
_cell.length_c                     277.827 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        18 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                155 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'H 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.48 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.33 
_exptl_crystal.description                  'Trapezoid morphology' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M lithium citrate tribasic tetrahydrate, 15 - 20% PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9537 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9537 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX2 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9DQF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.90 
_reflns.d_resolution_low                               46.30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     39299 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                20.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.00 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.149 
_reflns.pdbx_Rpim_I_all                                0.033 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       792650 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.145 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.94 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           52327 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2491 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               21.0 
_reflns_shell.pdbx_chi_squared                              0.95 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.4 
_reflns_shell.pdbx_Rrim_I_all                               2.666 
_reflns_shell.pdbx_Rpim_I_all                               0.580 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.680 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.602 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             41.10 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39214 
_refine.ls_number_reflns_R_free                  1984 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.77 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2001 
_refine.ls_R_factor_R_free                       0.2320 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1983 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.78 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.19 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        41.10 
_refine_hist.number_atoms_solvent             190 
_refine_hist.number_atoms_total               3550 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3296 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         64 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  ? 3422 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.913  ? 4662 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 10.289 ? 499  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.063  ? 552  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.011  ? 613  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.95  . . 136 2629 100.00 . . . . 0.2906 . . . . . . . . . . . 0.3054 
'X-RAY DIFFRACTION' 1.95 2.00  . . 158 2644 100.00 . . . . 0.2707 . . . . . . . . . . . 0.3041 
'X-RAY DIFFRACTION' 2.00 2.06  . . 151 2582 100.00 . . . . 0.2544 . . . . . . . . . . . 0.3465 
'X-RAY DIFFRACTION' 2.06 2.13  . . 141 2629 100.00 . . . . 0.2357 . . . . . . . . . . . 0.2434 
'X-RAY DIFFRACTION' 2.13 2.20  . . 151 2629 100.00 . . . . 0.2218 . . . . . . . . . . . 0.2635 
'X-RAY DIFFRACTION' 2.20 2.29  . . 127 2666 100.00 . . . . 0.2078 . . . . . . . . . . . 0.2609 
'X-RAY DIFFRACTION' 2.29 2.39  . . 130 2638 100.00 . . . . 0.2022 . . . . . . . . . . . 0.2554 
'X-RAY DIFFRACTION' 2.39 2.52  . . 140 2658 100.00 . . . . 0.2041 . . . . . . . . . . . 0.2648 
'X-RAY DIFFRACTION' 2.52 2.68  . . 150 2627 100.00 . . . . 0.2047 . . . . . . . . . . . 0.2541 
'X-RAY DIFFRACTION' 2.68 2.88  . . 122 2687 100.00 . . . . 0.1986 . . . . . . . . . . . 0.2683 
'X-RAY DIFFRACTION' 2.88 3.17  . . 150 2643 100.00 . . . . 0.1951 . . . . . . . . . . . 0.2467 
'X-RAY DIFFRACTION' 3.17 3.63  . . 135 2693 100.00 . . . . 0.1955 . . . . . . . . . . . 0.1996 
'X-RAY DIFFRACTION' 3.63 4.58  . . 146 2702 100.00 . . . . 0.1674 . . . . . . . . . . . 0.2141 
'X-RAY DIFFRACTION' 4.58 41.10 . . 147 2803 99.00  . . . . 0.1913 . . . . . . . . . . . 0.1921 
# 
_struct.entry_id                     9DQF 
_struct.title                        
'Crystal structure of bifunctional GlmU from Staphylococcus aureus NCTC 8325 complexed with acetyl CoA and citrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQF 
_struct_keywords.text            'uridyltransferase, acetyltransferase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    GLMU_STAA8 
_struct_ref.pdbx_db_accession          Q2G0S3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLVTLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9DQF 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 11 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 460 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q2G0S3 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  450 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       450 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQF MET A 1  ? UNP Q2G0S3 ? ? 'initiating methionine' -9 1  
1 9DQF GLY A 2  ? UNP Q2G0S3 ? ? 'expression tag'        -8 2  
1 9DQF HIS A 3  ? UNP Q2G0S3 ? ? 'expression tag'        -7 3  
1 9DQF HIS A 4  ? UNP Q2G0S3 ? ? 'expression tag'        -6 4  
1 9DQF HIS A 5  ? UNP Q2G0S3 ? ? 'expression tag'        -5 5  
1 9DQF HIS A 6  ? UNP Q2G0S3 ? ? 'expression tag'        -4 6  
1 9DQF HIS A 7  ? UNP Q2G0S3 ? ? 'expression tag'        -3 7  
1 9DQF HIS A 8  ? UNP Q2G0S3 ? ? 'expression tag'        -2 8  
1 9DQF GLY A 9  ? UNP Q2G0S3 ? ? 'expression tag'        -1 9  
1 9DQF SER A 10 ? UNP Q2G0S3 ? ? 'expression tag'        0  10 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_545 -y,x-y-1,z  -0.5000000000 -0.8660254038 0.0000000000 47.9900000000 0.8660254038  
-0.5000000000 0.0000000000 -83.1211182552 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 3_655 -x+y+1,-x,z -0.5000000000 0.8660254038  0.0000000000 95.9800000000 -0.8660254038 
-0.5000000000 0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 23  ? LYS A 27  ? GLY A 13  LYS A 17  5 ? 5  
HELX_P HELX_P2  AA2 TYR A 31  ? LEU A 34  ? TYR A 21  LEU A 24  5 ? 4  
HELX_P HELX_P3  AA3 MET A 42  ? SER A 53  ? MET A 32  SER A 43  1 ? 12 
HELX_P HELX_P4  AA4 ALA A 66  ? GLY A 74  ? ALA A 56  GLY A 64  1 ? 9  
HELX_P HELX_P5  AA5 GLU A 75  ? SER A 77  ? GLU A 65  SER A 67  5 ? 3  
HELX_P HELX_P6  AA6 GLY A 87  ? MET A 94  ? GLY A 77  MET A 84  1 ? 8  
HELX_P HELX_P7  AA7 ALA A 95  ? GLU A 100 ? ALA A 85  GLU A 90  1 ? 6  
HELX_P HELX_P8  AA8 THR A 117 ? ALA A 131 ? THR A 107 ALA A 121 1 ? 15 
HELX_P HELX_P9  AA9 GLU A 164 ? ALA A 168 ? GLU A 154 ALA A 158 5 ? 5  
HELX_P HELX_P10 AB1 ALA A 171 ? ILE A 175 ? ALA A 161 ILE A 165 5 ? 5  
HELX_P HELX_P11 AB2 ASN A 187 ? THR A 195 ? ASN A 177 THR A 185 1 ? 9  
HELX_P HELX_P12 AB3 LEU A 208 ? ASN A 217 ? LEU A 198 ASN A 207 1 ? 10 
HELX_P HELX_P13 AB4 ASP A 229 ? MET A 234 ? ASP A 219 MET A 224 5 ? 6  
HELX_P HELX_P14 AB5 ASP A 238 ? ASN A 260 ? ASP A 228 ASN A 250 1 ? 23 
HELX_P HELX_P15 AB6 ASP A 266 ? THR A 270 ? ASP A 256 THR A 260 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 336 A . ? GLY 326 A PRO 337 A ? PRO 327 A 1 1.38  
2 ALA 420 A . ? ALA 410 A PRO 421 A ? PRO 411 A 1 -3.44 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7  ? 
AA2 ? 2  ? 
AA3 ? 2  ? 
AA4 ? 11 ? 
AA5 ? 11 ? 
AA6 ? 9  ? 
AA7 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? parallel      
AA1 2  3  ? parallel      
AA1 3  4  ? parallel      
AA1 4  5  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? parallel      
AA2 1  2  ? anti-parallel 
AA3 1  2  ? anti-parallel 
AA4 1  2  ? parallel      
AA4 2  3  ? parallel      
AA4 3  4  ? parallel      
AA4 4  5  ? parallel      
AA4 5  6  ? parallel      
AA4 6  7  ? parallel      
AA4 7  8  ? parallel      
AA4 8  9  ? parallel      
AA4 9  10 ? parallel      
AA4 10 11 ? parallel      
AA5 1  2  ? parallel      
AA5 2  3  ? parallel      
AA5 3  4  ? parallel      
AA5 4  5  ? parallel      
AA5 5  6  ? parallel      
AA5 6  7  ? parallel      
AA5 7  8  ? parallel      
AA5 8  9  ? parallel      
AA5 9  10 ? parallel      
AA5 10 11 ? parallel      
AA6 1  2  ? parallel      
AA6 2  3  ? parallel      
AA6 3  4  ? parallel      
AA6 4  5  ? parallel      
AA6 5  6  ? parallel      
AA6 6  7  ? parallel      
AA6 7  8  ? parallel      
AA6 8  9  ? parallel      
AA7 1  2  ? parallel      
AA7 2  3  ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  LEU A 78  ? PHE A 81  ? LEU A 68  PHE A 71  
AA1 2  GLN A 57  ? VAL A 62  ? GLN A 47  VAL A 52  
AA1 3  ARG A 13  ? LEU A 18  ? ARG A 3   LEU A 8   
AA1 4  THR A 105 ? CYS A 110 ? THR A 95  CYS A 100 
AA1 5  GLU A 177 ? ASN A 186 ? GLU A 167 ASN A 176 
AA1 6  ALA A 135 ? SER A 141 ? ALA A 125 SER A 131 
AA1 7  VAL A 222 ? ARG A 226 ? VAL A 212 ARG A 216 
AA2 1  GLU A 36  ? VAL A 37  ? GLU A 26  VAL A 27  
AA2 2  LYS A 40  ? PRO A 41  ? LYS A 30  PRO A 31  
AA3 1  ARG A 150 ? ARG A 153 ? ARG A 140 ARG A 143 
AA3 2  LEU A 159 ? VAL A 163 ? LEU A 149 VAL A 153 
AA4 1  THR A 263 ? ILE A 264 ? THR A 253 ILE A 254 
AA4 2  VAL A 283 ? ILE A 284 ? VAL A 273 ILE A 274 
AA4 3  VAL A 301 ? ILE A 302 ? VAL A 291 ILE A 292 
AA4 4  CYS A 318 ? ILE A 319 ? CYS A 308 ILE A 309 
AA4 5  LYS A 334 ? VAL A 335 ? LYS A 324 VAL A 325 
AA4 6  LYS A 352 ? ASN A 355 ? LYS A 342 ASN A 345 
AA4 7  LYS A 369 ? HIS A 372 ? LYS A 359 HIS A 362 
AA4 8  ASN A 386 ? ILE A 387 ? ASN A 376 ILE A 377 
AA4 9  PHE A 411 ? VAL A 412 ? PHE A 401 VAL A 402 
AA4 10 LEU A 429 ? VAL A 430 ? LEU A 419 VAL A 420 
AA4 11 LEU A 445 ? ALA A 446 ? LEU A 435 ALA A 436 
AA5 1  TYR A 271 ? ILE A 272 ? TYR A 261 ILE A 262 
AA5 2  ARG A 289 ? ASN A 291 ? ARG A 279 ASN A 281 
AA5 3  GLU A 307 ? ASN A 309 ? GLU A 297 ASN A 299 
AA5 4  VAL A 323 ? ASN A 325 ? VAL A 313 ASN A 315 
AA5 5  GLN A 340 ? LEU A 341 ? GLN A 330 LEU A 331 
AA5 6  GLU A 358 ? LEU A 364 ? GLU A 348 LEU A 354 
AA5 7  ALA A 345 ? LEU A 347 ? ALA A 335 LEU A 337 
AA5 8  SER A 328 ? VAL A 329 ? SER A 318 VAL A 319 
AA5 9  THR A 312 ? ILE A 313 ? THR A 302 ILE A 303 
AA5 10 THR A 294 ? ILE A 296 ? THR A 284 ILE A 286 
AA5 11 VAL A 276 ? ILE A 278 ? VAL A 266 ILE A 268 
AA6 1  TYR A 271 ? ILE A 272 ? TYR A 261 ILE A 262 
AA6 2  ARG A 289 ? ASN A 291 ? ARG A 279 ASN A 281 
AA6 3  GLU A 307 ? ASN A 309 ? GLU A 297 ASN A 299 
AA6 4  VAL A 323 ? ASN A 325 ? VAL A 313 ASN A 315 
AA6 5  GLN A 340 ? LEU A 341 ? GLN A 330 LEU A 331 
AA6 6  GLU A 358 ? LEU A 364 ? GLU A 348 LEU A 354 
AA6 7  TYR A 375 ? ILE A 381 ? TYR A 365 ILE A 371 
AA6 8  THR A 404 ? VAL A 406 ? THR A 394 VAL A 396 
AA6 9  VAL A 422 ? ILE A 424 ? VAL A 412 ILE A 414 
AA7 1  ILE A 392 ? VAL A 394 ? ILE A 382 VAL A 384 
AA7 2  ASN A 417 ? VAL A 419 ? ASN A 407 VAL A 409 
AA7 3  THR A 435 ? ILE A 436 ? THR A 425 ILE A 426 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  O LEU A 78  ? O LEU A 68  N VAL A 58  ? N VAL A 48  
AA1 2  3  O VAL A 59  ? O VAL A 49  N ALA A 15  ? N ALA A 5   
AA1 3  4  N HIS A 14  ? N HIS A 4   O THR A 105 ? O THR A 95  
AA1 4  5  N THR A 106 ? N THR A 96  O PHE A 185 ? O PHE A 175 
AA1 5  6  O ILE A 178 ? O ILE A 168 N ALA A 140 ? N ALA A 130 
AA1 6  7  N SER A 139 ? N SER A 129 O TYR A 225 ? O TYR A 215 
AA2 1  2  N VAL A 37  ? N VAL A 27  O LYS A 40  ? O LYS A 30  
AA3 1  2  N VAL A 152 ? N VAL A 142 O GLU A 160 ? O GLU A 150 
AA4 1  2  N THR A 263 ? N THR A 253 O ILE A 284 ? O ILE A 274 
AA4 2  3  N VAL A 283 ? N VAL A 273 O ILE A 302 ? O ILE A 292 
AA4 3  4  N VAL A 301 ? N VAL A 291 O ILE A 319 ? O ILE A 309 
AA4 4  5  N CYS A 318 ? N CYS A 308 O VAL A 335 ? O VAL A 325 
AA4 5  6  N LYS A 334 ? N LYS A 324 O VAL A 353 ? O VAL A 343 
AA4 6  7  N LYS A 352 ? N LYS A 342 O VAL A 370 ? O VAL A 360 
AA4 7  8  N LYS A 369 ? N LYS A 359 O ILE A 387 ? O ILE A 377 
AA4 8  9  N ASN A 386 ? N ASN A 376 O VAL A 412 ? O VAL A 402 
AA4 9  10 N PHE A 411 ? N PHE A 401 O VAL A 430 ? O VAL A 420 
AA4 10 11 N LEU A 429 ? N LEU A 419 O ALA A 446 ? O ALA A 436 
AA5 1  2  N TYR A 271 ? N TYR A 261 O ILE A 290 ? O ILE A 280 
AA5 2  3  N ARG A 289 ? N ARG A 279 O ILE A 308 ? O ILE A 298 
AA5 3  4  N ASN A 309 ? N ASN A 299 O VAL A 324 ? O VAL A 314 
AA5 4  5  N VAL A 323 ? N VAL A 313 O LEU A 341 ? O LEU A 331 
AA5 5  6  N GLN A 340 ? N GLN A 330 O ILE A 359 ? O ILE A 349 
AA5 6  7  O ALA A 362 ? O ALA A 352 N GLN A 346 ? N GLN A 336 
AA5 7  8  O LEU A 347 ? O LEU A 337 N SER A 328 ? N SER A 318 
AA5 8  9  O VAL A 329 ? O VAL A 319 N THR A 312 ? N THR A 302 
AA5 9  10 O ILE A 313 ? O ILE A 303 N GLU A 295 ? N GLU A 285 
AA5 10 11 O ILE A 296 ? O ILE A 286 N THR A 277 ? N THR A 267 
AA6 1  2  N TYR A 271 ? N TYR A 261 O ILE A 290 ? O ILE A 280 
AA6 2  3  N ARG A 289 ? N ARG A 279 O ILE A 308 ? O ILE A 298 
AA6 3  4  N ASN A 309 ? N ASN A 299 O VAL A 324 ? O VAL A 314 
AA6 4  5  N VAL A 323 ? N VAL A 313 O LEU A 341 ? O LEU A 331 
AA6 5  6  N GLN A 340 ? N GLN A 330 O ILE A 359 ? O ILE A 349 
AA6 6  7  N ASP A 363 ? N ASP A 353 O ILE A 381 ? O ILE A 371 
AA6 7  8  N VAL A 380 ? N VAL A 370 O VAL A 406 ? O VAL A 396 
AA6 8  9  N ILE A 405 ? N ILE A 395 O ILE A 424 ? O ILE A 414 
AA7 1  2  N ILE A 392 ? N ILE A 382 O LEU A 418 ? O LEU A 408 
AA7 2  3  N ASN A 417 ? N ASN A 407 O ILE A 436 ? O ILE A 426 
# 
_pdbx_entry_details.entry_id                   9DQF 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OE2 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    GLU 
_pdbx_validate_symm_contact.auth_seq_id_1     93 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OH 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    TYR 
_pdbx_validate_symm_contact.auth_seq_id_2     196 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   3_765 
_pdbx_validate_symm_contact.dist              2.10 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 207 ? ? -66.38  2.15   
2 1 GLN A 311 ? ? 25.68   67.81  
3 1 GLU A 389 ? ? -135.44 -49.01 
4 1 ALA A 438 ? ? -153.41 76.68  
5 1 ARG A 449 ? ? -108.33 41.44  
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     279 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    A 
_pdbx_validate_planes.rmsd            0.074 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 746 ? D HOH . 
2 1 A HOH 785 ? D HOH . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -9 ? A MET 1  
2  1 Y 1 A GLY -8 ? A GLY 2  
3  1 Y 1 A HIS -7 ? A HIS 3  
4  1 Y 1 A HIS -6 ? A HIS 4  
5  1 Y 1 A HIS -5 ? A HIS 5  
6  1 Y 1 A HIS -4 ? A HIS 6  
7  1 Y 1 A HIS -3 ? A HIS 7  
8  1 Y 1 A HIS -2 ? A HIS 8  
9  1 Y 1 A GLY -1 ? A GLY 9  
10 1 Y 1 A SER 0  ? A SER 10 
11 1 Y 1 A MET 1  ? A MET 11 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACO N1A  N Y N 1   
ACO C2A  C Y N 2   
ACO N3A  N Y N 3   
ACO C4A  C Y N 4   
ACO C5A  C Y N 5   
ACO C6A  C Y N 6   
ACO N6A  N N N 7   
ACO N7A  N Y N 8   
ACO C8A  C Y N 9   
ACO N9A  N Y N 10  
ACO C1B  C N R 11  
ACO C2B  C N R 12  
ACO O2B  O N N 13  
ACO C3B  C N S 14  
ACO O3B  O N N 15  
ACO P3B  P N N 16  
ACO O7A  O N N 17  
ACO O8A  O N N 18  
ACO O9A  O N N 19  
ACO C4B  C N R 20  
ACO O4B  O N N 21  
ACO C5B  C N N 22  
ACO O5B  O N N 23  
ACO P1A  P N S 24  
ACO O1A  O N N 25  
ACO O2A  O N N 26  
ACO O3A  O N N 27  
ACO P2A  P N S 28  
ACO O4A  O N N 29  
ACO O5A  O N N 30  
ACO O6A  O N N 31  
ACO CBP  C N N 32  
ACO CCP  C N N 33  
ACO CDP  C N N 34  
ACO CEP  C N N 35  
ACO CAP  C N R 36  
ACO OAP  O N N 37  
ACO C9P  C N N 38  
ACO O9P  O N N 39  
ACO N8P  N N N 40  
ACO C7P  C N N 41  
ACO C6P  C N N 42  
ACO C5P  C N N 43  
ACO O5P  O N N 44  
ACO N4P  N N N 45  
ACO C3P  C N N 46  
ACO C2P  C N N 47  
ACO S1P  S N N 48  
ACO C    C N N 49  
ACO O    O N N 50  
ACO CH3  C N N 51  
ACO H2A  H N N 52  
ACO H61A H N N 53  
ACO H62A H N N 54  
ACO H8A  H N N 55  
ACO H1B  H N N 56  
ACO H2B  H N N 57  
ACO HO2A H N N 58  
ACO H3B  H N N 59  
ACO HOA8 H N N 60  
ACO HOA9 H N N 61  
ACO H4B  H N N 62  
ACO H51A H N N 63  
ACO H52A H N N 64  
ACO HOA2 H N N 65  
ACO HOA5 H N N 66  
ACO H121 H N N 67  
ACO H122 H N N 68  
ACO H131 H N N 69  
ACO H132 H N N 70  
ACO H133 H N N 71  
ACO H141 H N N 72  
ACO H142 H N N 73  
ACO H143 H N N 74  
ACO H10  H N N 75  
ACO HO1  H N N 76  
ACO HN8  H N N 77  
ACO H71  H N N 78  
ACO H72  H N N 79  
ACO H61  H N N 80  
ACO H62  H N N 81  
ACO HN4  H N N 82  
ACO H31  H N N 83  
ACO H32  H N N 84  
ACO H21  H N N 85  
ACO H22  H N N 86  
ACO HH31 H N N 87  
ACO HH32 H N N 88  
ACO HH33 H N N 89  
ALA N    N N N 90  
ALA CA   C N S 91  
ALA C    C N N 92  
ALA O    O N N 93  
ALA CB   C N N 94  
ALA OXT  O N N 95  
ALA H    H N N 96  
ALA H2   H N N 97  
ALA HA   H N N 98  
ALA HB1  H N N 99  
ALA HB2  H N N 100 
ALA HB3  H N N 101 
ALA HXT  H N N 102 
ARG N    N N N 103 
ARG CA   C N S 104 
ARG C    C N N 105 
ARG O    O N N 106 
ARG CB   C N N 107 
ARG CG   C N N 108 
ARG CD   C N N 109 
ARG NE   N N N 110 
ARG CZ   C N N 111 
ARG NH1  N N N 112 
ARG NH2  N N N 113 
ARG OXT  O N N 114 
ARG H    H N N 115 
ARG H2   H N N 116 
ARG HA   H N N 117 
ARG HB2  H N N 118 
ARG HB3  H N N 119 
ARG HG2  H N N 120 
ARG HG3  H N N 121 
ARG HD2  H N N 122 
ARG HD3  H N N 123 
ARG HE   H N N 124 
ARG HH11 H N N 125 
ARG HH12 H N N 126 
ARG HH21 H N N 127 
ARG HH22 H N N 128 
ARG HXT  H N N 129 
ASN N    N N N 130 
ASN CA   C N S 131 
ASN C    C N N 132 
ASN O    O N N 133 
ASN CB   C N N 134 
ASN CG   C N N 135 
ASN OD1  O N N 136 
ASN ND2  N N N 137 
ASN OXT  O N N 138 
ASN H    H N N 139 
ASN H2   H N N 140 
ASN HA   H N N 141 
ASN HB2  H N N 142 
ASN HB3  H N N 143 
ASN HD21 H N N 144 
ASN HD22 H N N 145 
ASN HXT  H N N 146 
ASP N    N N N 147 
ASP CA   C N S 148 
ASP C    C N N 149 
ASP O    O N N 150 
ASP CB   C N N 151 
ASP CG   C N N 152 
ASP OD1  O N N 153 
ASP OD2  O N N 154 
ASP OXT  O N N 155 
ASP H    H N N 156 
ASP H2   H N N 157 
ASP HA   H N N 158 
ASP HB2  H N N 159 
ASP HB3  H N N 160 
ASP HD2  H N N 161 
ASP HXT  H N N 162 
CIT C1   C N N 163 
CIT O1   O N N 164 
CIT O2   O N N 165 
CIT C2   C N N 166 
CIT C3   C N N 167 
CIT O7   O N N 168 
CIT C4   C N N 169 
CIT C5   C N N 170 
CIT O3   O N N 171 
CIT O4   O N N 172 
CIT C6   C N N 173 
CIT O5   O N N 174 
CIT O6   O N N 175 
CIT HO2  H N N 176 
CIT H21  H N N 177 
CIT H22  H N N 178 
CIT HO7  H N N 179 
CIT H41  H N N 180 
CIT H42  H N N 181 
CIT HO4  H N N 182 
CIT HO6  H N N 183 
CYS N    N N N 184 
CYS CA   C N R 185 
CYS C    C N N 186 
CYS O    O N N 187 
CYS CB   C N N 188 
CYS SG   S N N 189 
CYS OXT  O N N 190 
CYS H    H N N 191 
CYS H2   H N N 192 
CYS HA   H N N 193 
CYS HB2  H N N 194 
CYS HB3  H N N 195 
CYS HG   H N N 196 
CYS HXT  H N N 197 
GLN N    N N N 198 
GLN CA   C N S 199 
GLN C    C N N 200 
GLN O    O N N 201 
GLN CB   C N N 202 
GLN CG   C N N 203 
GLN CD   C N N 204 
GLN OE1  O N N 205 
GLN NE2  N N N 206 
GLN OXT  O N N 207 
GLN H    H N N 208 
GLN H2   H N N 209 
GLN HA   H N N 210 
GLN HB2  H N N 211 
GLN HB3  H N N 212 
GLN HG2  H N N 213 
GLN HG3  H N N 214 
GLN HE21 H N N 215 
GLN HE22 H N N 216 
GLN HXT  H N N 217 
GLU N    N N N 218 
GLU CA   C N S 219 
GLU C    C N N 220 
GLU O    O N N 221 
GLU CB   C N N 222 
GLU CG   C N N 223 
GLU CD   C N N 224 
GLU OE1  O N N 225 
GLU OE2  O N N 226 
GLU OXT  O N N 227 
GLU H    H N N 228 
GLU H2   H N N 229 
GLU HA   H N N 230 
GLU HB2  H N N 231 
GLU HB3  H N N 232 
GLU HG2  H N N 233 
GLU HG3  H N N 234 
GLU HE2  H N N 235 
GLU HXT  H N N 236 
GLY N    N N N 237 
GLY CA   C N N 238 
GLY C    C N N 239 
GLY O    O N N 240 
GLY OXT  O N N 241 
GLY H    H N N 242 
GLY H2   H N N 243 
GLY HA2  H N N 244 
GLY HA3  H N N 245 
GLY HXT  H N N 246 
HIS N    N N N 247 
HIS CA   C N S 248 
HIS C    C N N 249 
HIS O    O N N 250 
HIS CB   C N N 251 
HIS CG   C Y N 252 
HIS ND1  N Y N 253 
HIS CD2  C Y N 254 
HIS CE1  C Y N 255 
HIS NE2  N Y N 256 
HIS OXT  O N N 257 
HIS H    H N N 258 
HIS H2   H N N 259 
HIS HA   H N N 260 
HIS HB2  H N N 261 
HIS HB3  H N N 262 
HIS HD1  H N N 263 
HIS HD2  H N N 264 
HIS HE1  H N N 265 
HIS HE2  H N N 266 
HIS HXT  H N N 267 
HOH O    O N N 268 
HOH H1   H N N 269 
HOH H2   H N N 270 
ILE N    N N N 271 
ILE CA   C N S 272 
ILE C    C N N 273 
ILE O    O N N 274 
ILE CB   C N S 275 
ILE CG1  C N N 276 
ILE CG2  C N N 277 
ILE CD1  C N N 278 
ILE OXT  O N N 279 
ILE H    H N N 280 
ILE H2   H N N 281 
ILE HA   H N N 282 
ILE HB   H N N 283 
ILE HG12 H N N 284 
ILE HG13 H N N 285 
ILE HG21 H N N 286 
ILE HG22 H N N 287 
ILE HG23 H N N 288 
ILE HD11 H N N 289 
ILE HD12 H N N 290 
ILE HD13 H N N 291 
ILE HXT  H N N 292 
LEU N    N N N 293 
LEU CA   C N S 294 
LEU C    C N N 295 
LEU O    O N N 296 
LEU CB   C N N 297 
LEU CG   C N N 298 
LEU CD1  C N N 299 
LEU CD2  C N N 300 
LEU OXT  O N N 301 
LEU H    H N N 302 
LEU H2   H N N 303 
LEU HA   H N N 304 
LEU HB2  H N N 305 
LEU HB3  H N N 306 
LEU HG   H N N 307 
LEU HD11 H N N 308 
LEU HD12 H N N 309 
LEU HD13 H N N 310 
LEU HD21 H N N 311 
LEU HD22 H N N 312 
LEU HD23 H N N 313 
LEU HXT  H N N 314 
LYS N    N N N 315 
LYS CA   C N S 316 
LYS C    C N N 317 
LYS O    O N N 318 
LYS CB   C N N 319 
LYS CG   C N N 320 
LYS CD   C N N 321 
LYS CE   C N N 322 
LYS NZ   N N N 323 
LYS OXT  O N N 324 
LYS H    H N N 325 
LYS H2   H N N 326 
LYS HA   H N N 327 
LYS HB2  H N N 328 
LYS HB3  H N N 329 
LYS HG2  H N N 330 
LYS HG3  H N N 331 
LYS HD2  H N N 332 
LYS HD3  H N N 333 
LYS HE2  H N N 334 
LYS HE3  H N N 335 
LYS HZ1  H N N 336 
LYS HZ2  H N N 337 
LYS HZ3  H N N 338 
LYS HXT  H N N 339 
MET N    N N N 340 
MET CA   C N S 341 
MET C    C N N 342 
MET O    O N N 343 
MET CB   C N N 344 
MET CG   C N N 345 
MET SD   S N N 346 
MET CE   C N N 347 
MET OXT  O N N 348 
MET H    H N N 349 
MET H2   H N N 350 
MET HA   H N N 351 
MET HB2  H N N 352 
MET HB3  H N N 353 
MET HG2  H N N 354 
MET HG3  H N N 355 
MET HE1  H N N 356 
MET HE2  H N N 357 
MET HE3  H N N 358 
MET HXT  H N N 359 
PHE N    N N N 360 
PHE CA   C N S 361 
PHE C    C N N 362 
PHE O    O N N 363 
PHE CB   C N N 364 
PHE CG   C Y N 365 
PHE CD1  C Y N 366 
PHE CD2  C Y N 367 
PHE CE1  C Y N 368 
PHE CE2  C Y N 369 
PHE CZ   C Y N 370 
PHE OXT  O N N 371 
PHE H    H N N 372 
PHE H2   H N N 373 
PHE HA   H N N 374 
PHE HB2  H N N 375 
PHE HB3  H N N 376 
PHE HD1  H N N 377 
PHE HD2  H N N 378 
PHE HE1  H N N 379 
PHE HE2  H N N 380 
PHE HZ   H N N 381 
PHE HXT  H N N 382 
PRO N    N N N 383 
PRO CA   C N S 384 
PRO C    C N N 385 
PRO O    O N N 386 
PRO CB   C N N 387 
PRO CG   C N N 388 
PRO CD   C N N 389 
PRO OXT  O N N 390 
PRO H    H N N 391 
PRO HA   H N N 392 
PRO HB2  H N N 393 
PRO HB3  H N N 394 
PRO HG2  H N N 395 
PRO HG3  H N N 396 
PRO HD2  H N N 397 
PRO HD3  H N N 398 
PRO HXT  H N N 399 
SER N    N N N 400 
SER CA   C N S 401 
SER C    C N N 402 
SER O    O N N 403 
SER CB   C N N 404 
SER OG   O N N 405 
SER OXT  O N N 406 
SER H    H N N 407 
SER H2   H N N 408 
SER HA   H N N 409 
SER HB2  H N N 410 
SER HB3  H N N 411 
SER HG   H N N 412 
SER HXT  H N N 413 
THR N    N N N 414 
THR CA   C N S 415 
THR C    C N N 416 
THR O    O N N 417 
THR CB   C N R 418 
THR OG1  O N N 419 
THR CG2  C N N 420 
THR OXT  O N N 421 
THR H    H N N 422 
THR H2   H N N 423 
THR HA   H N N 424 
THR HB   H N N 425 
THR HG1  H N N 426 
THR HG21 H N N 427 
THR HG22 H N N 428 
THR HG23 H N N 429 
THR HXT  H N N 430 
TYR N    N N N 431 
TYR CA   C N S 432 
TYR C    C N N 433 
TYR O    O N N 434 
TYR CB   C N N 435 
TYR CG   C Y N 436 
TYR CD1  C Y N 437 
TYR CD2  C Y N 438 
TYR CE1  C Y N 439 
TYR CE2  C Y N 440 
TYR CZ   C Y N 441 
TYR OH   O N N 442 
TYR OXT  O N N 443 
TYR H    H N N 444 
TYR H2   H N N 445 
TYR HA   H N N 446 
TYR HB2  H N N 447 
TYR HB3  H N N 448 
TYR HD1  H N N 449 
TYR HD2  H N N 450 
TYR HE1  H N N 451 
TYR HE2  H N N 452 
TYR HH   H N N 453 
TYR HXT  H N N 454 
VAL N    N N N 455 
VAL CA   C N S 456 
VAL C    C N N 457 
VAL O    O N N 458 
VAL CB   C N N 459 
VAL CG1  C N N 460 
VAL CG2  C N N 461 
VAL OXT  O N N 462 
VAL H    H N N 463 
VAL H2   H N N 464 
VAL HA   H N N 465 
VAL HB   H N N 466 
VAL HG11 H N N 467 
VAL HG12 H N N 468 
VAL HG13 H N N 469 
VAL HG21 H N N 470 
VAL HG22 H N N 471 
VAL HG23 H N N 472 
VAL HXT  H N N 473 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACO N1A C2A  sing Y N 1   
ACO N1A C6A  doub Y N 2   
ACO C2A N3A  doub Y N 3   
ACO C2A H2A  sing N N 4   
ACO N3A C4A  sing Y N 5   
ACO C4A C5A  doub Y N 6   
ACO C4A N9A  sing Y N 7   
ACO C5A C6A  sing Y N 8   
ACO C5A N7A  sing Y N 9   
ACO C6A N6A  sing N N 10  
ACO N6A H61A sing N N 11  
ACO N6A H62A sing N N 12  
ACO N7A C8A  doub Y N 13  
ACO C8A N9A  sing Y N 14  
ACO C8A H8A  sing N N 15  
ACO N9A C1B  sing N N 16  
ACO C1B C2B  sing N N 17  
ACO C1B O4B  sing N N 18  
ACO C1B H1B  sing N N 19  
ACO C2B O2B  sing N N 20  
ACO C2B C3B  sing N N 21  
ACO C2B H2B  sing N N 22  
ACO O2B HO2A sing N N 23  
ACO C3B O3B  sing N N 24  
ACO C3B C4B  sing N N 25  
ACO C3B H3B  sing N N 26  
ACO O3B P3B  sing N N 27  
ACO P3B O7A  doub N N 28  
ACO P3B O8A  sing N N 29  
ACO P3B O9A  sing N N 30  
ACO O8A HOA8 sing N N 31  
ACO O9A HOA9 sing N N 32  
ACO C4B O4B  sing N N 33  
ACO C4B C5B  sing N N 34  
ACO C4B H4B  sing N N 35  
ACO C5B O5B  sing N N 36  
ACO C5B H51A sing N N 37  
ACO C5B H52A sing N N 38  
ACO O5B P1A  sing N N 39  
ACO P1A O1A  doub N N 40  
ACO P1A O2A  sing N N 41  
ACO P1A O3A  sing N N 42  
ACO O2A HOA2 sing N N 43  
ACO O3A P2A  sing N N 44  
ACO P2A O4A  doub N N 45  
ACO P2A O5A  sing N N 46  
ACO P2A O6A  sing N N 47  
ACO O5A HOA5 sing N N 48  
ACO O6A CCP  sing N N 49  
ACO CBP CCP  sing N N 50  
ACO CBP CDP  sing N N 51  
ACO CBP CEP  sing N N 52  
ACO CBP CAP  sing N N 53  
ACO CCP H121 sing N N 54  
ACO CCP H122 sing N N 55  
ACO CDP H131 sing N N 56  
ACO CDP H132 sing N N 57  
ACO CDP H133 sing N N 58  
ACO CEP H141 sing N N 59  
ACO CEP H142 sing N N 60  
ACO CEP H143 sing N N 61  
ACO CAP OAP  sing N N 62  
ACO CAP C9P  sing N N 63  
ACO CAP H10  sing N N 64  
ACO OAP HO1  sing N N 65  
ACO C9P O9P  doub N N 66  
ACO C9P N8P  sing N N 67  
ACO N8P C7P  sing N N 68  
ACO N8P HN8  sing N N 69  
ACO C7P C6P  sing N N 70  
ACO C7P H71  sing N N 71  
ACO C7P H72  sing N N 72  
ACO C6P C5P  sing N N 73  
ACO C6P H61  sing N N 74  
ACO C6P H62  sing N N 75  
ACO C5P O5P  doub N N 76  
ACO C5P N4P  sing N N 77  
ACO N4P C3P  sing N N 78  
ACO N4P HN4  sing N N 79  
ACO C3P C2P  sing N N 80  
ACO C3P H31  sing N N 81  
ACO C3P H32  sing N N 82  
ACO C2P S1P  sing N N 83  
ACO C2P H21  sing N N 84  
ACO C2P H22  sing N N 85  
ACO S1P C    sing N N 86  
ACO C   O    doub N N 87  
ACO C   CH3  sing N N 88  
ACO CH3 HH31 sing N N 89  
ACO CH3 HH32 sing N N 90  
ACO CH3 HH33 sing N N 91  
ALA N   CA   sing N N 92  
ALA N   H    sing N N 93  
ALA N   H2   sing N N 94  
ALA CA  C    sing N N 95  
ALA CA  CB   sing N N 96  
ALA CA  HA   sing N N 97  
ALA C   O    doub N N 98  
ALA C   OXT  sing N N 99  
ALA CB  HB1  sing N N 100 
ALA CB  HB2  sing N N 101 
ALA CB  HB3  sing N N 102 
ALA OXT HXT  sing N N 103 
ARG N   CA   sing N N 104 
ARG N   H    sing N N 105 
ARG N   H2   sing N N 106 
ARG CA  C    sing N N 107 
ARG CA  CB   sing N N 108 
ARG CA  HA   sing N N 109 
ARG C   O    doub N N 110 
ARG C   OXT  sing N N 111 
ARG CB  CG   sing N N 112 
ARG CB  HB2  sing N N 113 
ARG CB  HB3  sing N N 114 
ARG CG  CD   sing N N 115 
ARG CG  HG2  sing N N 116 
ARG CG  HG3  sing N N 117 
ARG CD  NE   sing N N 118 
ARG CD  HD2  sing N N 119 
ARG CD  HD3  sing N N 120 
ARG NE  CZ   sing N N 121 
ARG NE  HE   sing N N 122 
ARG CZ  NH1  sing N N 123 
ARG CZ  NH2  doub N N 124 
ARG NH1 HH11 sing N N 125 
ARG NH1 HH12 sing N N 126 
ARG NH2 HH21 sing N N 127 
ARG NH2 HH22 sing N N 128 
ARG OXT HXT  sing N N 129 
ASN N   CA   sing N N 130 
ASN N   H    sing N N 131 
ASN N   H2   sing N N 132 
ASN CA  C    sing N N 133 
ASN CA  CB   sing N N 134 
ASN CA  HA   sing N N 135 
ASN C   O    doub N N 136 
ASN C   OXT  sing N N 137 
ASN CB  CG   sing N N 138 
ASN CB  HB2  sing N N 139 
ASN CB  HB3  sing N N 140 
ASN CG  OD1  doub N N 141 
ASN CG  ND2  sing N N 142 
ASN ND2 HD21 sing N N 143 
ASN ND2 HD22 sing N N 144 
ASN OXT HXT  sing N N 145 
ASP N   CA   sing N N 146 
ASP N   H    sing N N 147 
ASP N   H2   sing N N 148 
ASP CA  C    sing N N 149 
ASP CA  CB   sing N N 150 
ASP CA  HA   sing N N 151 
ASP C   O    doub N N 152 
ASP C   OXT  sing N N 153 
ASP CB  CG   sing N N 154 
ASP CB  HB2  sing N N 155 
ASP CB  HB3  sing N N 156 
ASP CG  OD1  doub N N 157 
ASP CG  OD2  sing N N 158 
ASP OD2 HD2  sing N N 159 
ASP OXT HXT  sing N N 160 
CIT C1  O1   doub N N 161 
CIT C1  O2   sing N N 162 
CIT C1  C2   sing N N 163 
CIT O2  HO2  sing N N 164 
CIT C2  C3   sing N N 165 
CIT C2  H21  sing N N 166 
CIT C2  H22  sing N N 167 
CIT C3  O7   sing N N 168 
CIT C3  C4   sing N N 169 
CIT C3  C6   sing N N 170 
CIT O7  HO7  sing N N 171 
CIT C4  C5   sing N N 172 
CIT C4  H41  sing N N 173 
CIT C4  H42  sing N N 174 
CIT C5  O3   doub N N 175 
CIT C5  O4   sing N N 176 
CIT O4  HO4  sing N N 177 
CIT C6  O5   doub N N 178 
CIT C6  O6   sing N N 179 
CIT O6  HO6  sing N N 180 
CYS N   CA   sing N N 181 
CYS N   H    sing N N 182 
CYS N   H2   sing N N 183 
CYS CA  C    sing N N 184 
CYS CA  CB   sing N N 185 
CYS CA  HA   sing N N 186 
CYS C   O    doub N N 187 
CYS C   OXT  sing N N 188 
CYS CB  SG   sing N N 189 
CYS CB  HB2  sing N N 190 
CYS CB  HB3  sing N N 191 
CYS SG  HG   sing N N 192 
CYS OXT HXT  sing N N 193 
GLN N   CA   sing N N 194 
GLN N   H    sing N N 195 
GLN N   H2   sing N N 196 
GLN CA  C    sing N N 197 
GLN CA  CB   sing N N 198 
GLN CA  HA   sing N N 199 
GLN C   O    doub N N 200 
GLN C   OXT  sing N N 201 
GLN CB  CG   sing N N 202 
GLN CB  HB2  sing N N 203 
GLN CB  HB3  sing N N 204 
GLN CG  CD   sing N N 205 
GLN CG  HG2  sing N N 206 
GLN CG  HG3  sing N N 207 
GLN CD  OE1  doub N N 208 
GLN CD  NE2  sing N N 209 
GLN NE2 HE21 sing N N 210 
GLN NE2 HE22 sing N N 211 
GLN OXT HXT  sing N N 212 
GLU N   CA   sing N N 213 
GLU N   H    sing N N 214 
GLU N   H2   sing N N 215 
GLU CA  C    sing N N 216 
GLU CA  CB   sing N N 217 
GLU CA  HA   sing N N 218 
GLU C   O    doub N N 219 
GLU C   OXT  sing N N 220 
GLU CB  CG   sing N N 221 
GLU CB  HB2  sing N N 222 
GLU CB  HB3  sing N N 223 
GLU CG  CD   sing N N 224 
GLU CG  HG2  sing N N 225 
GLU CG  HG3  sing N N 226 
GLU CD  OE1  doub N N 227 
GLU CD  OE2  sing N N 228 
GLU OE2 HE2  sing N N 229 
GLU OXT HXT  sing N N 230 
GLY N   CA   sing N N 231 
GLY N   H    sing N N 232 
GLY N   H2   sing N N 233 
GLY CA  C    sing N N 234 
GLY CA  HA2  sing N N 235 
GLY CA  HA3  sing N N 236 
GLY C   O    doub N N 237 
GLY C   OXT  sing N N 238 
GLY OXT HXT  sing N N 239 
HIS N   CA   sing N N 240 
HIS N   H    sing N N 241 
HIS N   H2   sing N N 242 
HIS CA  C    sing N N 243 
HIS CA  CB   sing N N 244 
HIS CA  HA   sing N N 245 
HIS C   O    doub N N 246 
HIS C   OXT  sing N N 247 
HIS CB  CG   sing N N 248 
HIS CB  HB2  sing N N 249 
HIS CB  HB3  sing N N 250 
HIS CG  ND1  sing Y N 251 
HIS CG  CD2  doub Y N 252 
HIS ND1 CE1  doub Y N 253 
HIS ND1 HD1  sing N N 254 
HIS CD2 NE2  sing Y N 255 
HIS CD2 HD2  sing N N 256 
HIS CE1 NE2  sing Y N 257 
HIS CE1 HE1  sing N N 258 
HIS NE2 HE2  sing N N 259 
HIS OXT HXT  sing N N 260 
HOH O   H1   sing N N 261 
HOH O   H2   sing N N 262 
ILE N   CA   sing N N 263 
ILE N   H    sing N N 264 
ILE N   H2   sing N N 265 
ILE CA  C    sing N N 266 
ILE CA  CB   sing N N 267 
ILE CA  HA   sing N N 268 
ILE C   O    doub N N 269 
ILE C   OXT  sing N N 270 
ILE CB  CG1  sing N N 271 
ILE CB  CG2  sing N N 272 
ILE CB  HB   sing N N 273 
ILE CG1 CD1  sing N N 274 
ILE CG1 HG12 sing N N 275 
ILE CG1 HG13 sing N N 276 
ILE CG2 HG21 sing N N 277 
ILE CG2 HG22 sing N N 278 
ILE CG2 HG23 sing N N 279 
ILE CD1 HD11 sing N N 280 
ILE CD1 HD12 sing N N 281 
ILE CD1 HD13 sing N N 282 
ILE OXT HXT  sing N N 283 
LEU N   CA   sing N N 284 
LEU N   H    sing N N 285 
LEU N   H2   sing N N 286 
LEU CA  C    sing N N 287 
LEU CA  CB   sing N N 288 
LEU CA  HA   sing N N 289 
LEU C   O    doub N N 290 
LEU C   OXT  sing N N 291 
LEU CB  CG   sing N N 292 
LEU CB  HB2  sing N N 293 
LEU CB  HB3  sing N N 294 
LEU CG  CD1  sing N N 295 
LEU CG  CD2  sing N N 296 
LEU CG  HG   sing N N 297 
LEU CD1 HD11 sing N N 298 
LEU CD1 HD12 sing N N 299 
LEU CD1 HD13 sing N N 300 
LEU CD2 HD21 sing N N 301 
LEU CD2 HD22 sing N N 302 
LEU CD2 HD23 sing N N 303 
LEU OXT HXT  sing N N 304 
LYS N   CA   sing N N 305 
LYS N   H    sing N N 306 
LYS N   H2   sing N N 307 
LYS CA  C    sing N N 308 
LYS CA  CB   sing N N 309 
LYS CA  HA   sing N N 310 
LYS C   O    doub N N 311 
LYS C   OXT  sing N N 312 
LYS CB  CG   sing N N 313 
LYS CB  HB2  sing N N 314 
LYS CB  HB3  sing N N 315 
LYS CG  CD   sing N N 316 
LYS CG  HG2  sing N N 317 
LYS CG  HG3  sing N N 318 
LYS CD  CE   sing N N 319 
LYS CD  HD2  sing N N 320 
LYS CD  HD3  sing N N 321 
LYS CE  NZ   sing N N 322 
LYS CE  HE2  sing N N 323 
LYS CE  HE3  sing N N 324 
LYS NZ  HZ1  sing N N 325 
LYS NZ  HZ2  sing N N 326 
LYS NZ  HZ3  sing N N 327 
LYS OXT HXT  sing N N 328 
MET N   CA   sing N N 329 
MET N   H    sing N N 330 
MET N   H2   sing N N 331 
MET CA  C    sing N N 332 
MET CA  CB   sing N N 333 
MET CA  HA   sing N N 334 
MET C   O    doub N N 335 
MET C   OXT  sing N N 336 
MET CB  CG   sing N N 337 
MET CB  HB2  sing N N 338 
MET CB  HB3  sing N N 339 
MET CG  SD   sing N N 340 
MET CG  HG2  sing N N 341 
MET CG  HG3  sing N N 342 
MET SD  CE   sing N N 343 
MET CE  HE1  sing N N 344 
MET CE  HE2  sing N N 345 
MET CE  HE3  sing N N 346 
MET OXT HXT  sing N N 347 
PHE N   CA   sing N N 348 
PHE N   H    sing N N 349 
PHE N   H2   sing N N 350 
PHE CA  C    sing N N 351 
PHE CA  CB   sing N N 352 
PHE CA  HA   sing N N 353 
PHE C   O    doub N N 354 
PHE C   OXT  sing N N 355 
PHE CB  CG   sing N N 356 
PHE CB  HB2  sing N N 357 
PHE CB  HB3  sing N N 358 
PHE CG  CD1  doub Y N 359 
PHE CG  CD2  sing Y N 360 
PHE CD1 CE1  sing Y N 361 
PHE CD1 HD1  sing N N 362 
PHE CD2 CE2  doub Y N 363 
PHE CD2 HD2  sing N N 364 
PHE CE1 CZ   doub Y N 365 
PHE CE1 HE1  sing N N 366 
PHE CE2 CZ   sing Y N 367 
PHE CE2 HE2  sing N N 368 
PHE CZ  HZ   sing N N 369 
PHE OXT HXT  sing N N 370 
PRO N   CA   sing N N 371 
PRO N   CD   sing N N 372 
PRO N   H    sing N N 373 
PRO CA  C    sing N N 374 
PRO CA  CB   sing N N 375 
PRO CA  HA   sing N N 376 
PRO C   O    doub N N 377 
PRO C   OXT  sing N N 378 
PRO CB  CG   sing N N 379 
PRO CB  HB2  sing N N 380 
PRO CB  HB3  sing N N 381 
PRO CG  CD   sing N N 382 
PRO CG  HG2  sing N N 383 
PRO CG  HG3  sing N N 384 
PRO CD  HD2  sing N N 385 
PRO CD  HD3  sing N N 386 
PRO OXT HXT  sing N N 387 
SER N   CA   sing N N 388 
SER N   H    sing N N 389 
SER N   H2   sing N N 390 
SER CA  C    sing N N 391 
SER CA  CB   sing N N 392 
SER CA  HA   sing N N 393 
SER C   O    doub N N 394 
SER C   OXT  sing N N 395 
SER CB  OG   sing N N 396 
SER CB  HB2  sing N N 397 
SER CB  HB3  sing N N 398 
SER OG  HG   sing N N 399 
SER OXT HXT  sing N N 400 
THR N   CA   sing N N 401 
THR N   H    sing N N 402 
THR N   H2   sing N N 403 
THR CA  C    sing N N 404 
THR CA  CB   sing N N 405 
THR CA  HA   sing N N 406 
THR C   O    doub N N 407 
THR C   OXT  sing N N 408 
THR CB  OG1  sing N N 409 
THR CB  CG2  sing N N 410 
THR CB  HB   sing N N 411 
THR OG1 HG1  sing N N 412 
THR CG2 HG21 sing N N 413 
THR CG2 HG22 sing N N 414 
THR CG2 HG23 sing N N 415 
THR OXT HXT  sing N N 416 
TYR N   CA   sing N N 417 
TYR N   H    sing N N 418 
TYR N   H2   sing N N 419 
TYR CA  C    sing N N 420 
TYR CA  CB   sing N N 421 
TYR CA  HA   sing N N 422 
TYR C   O    doub N N 423 
TYR C   OXT  sing N N 424 
TYR CB  CG   sing N N 425 
TYR CB  HB2  sing N N 426 
TYR CB  HB3  sing N N 427 
TYR CG  CD1  doub Y N 428 
TYR CG  CD2  sing Y N 429 
TYR CD1 CE1  sing Y N 430 
TYR CD1 HD1  sing N N 431 
TYR CD2 CE2  doub Y N 432 
TYR CD2 HD2  sing N N 433 
TYR CE1 CZ   doub Y N 434 
TYR CE1 HE1  sing N N 435 
TYR CE2 CZ   sing Y N 436 
TYR CE2 HE2  sing N N 437 
TYR CZ  OH   sing N N 438 
TYR OH  HH   sing N N 439 
TYR OXT HXT  sing N N 440 
VAL N   CA   sing N N 441 
VAL N   H    sing N N 442 
VAL N   H2   sing N N 443 
VAL CA  C    sing N N 444 
VAL CA  CB   sing N N 445 
VAL CA  HA   sing N N 446 
VAL C   O    doub N N 447 
VAL C   OXT  sing N N 448 
VAL CB  CG1  sing N N 449 
VAL CB  CG2  sing N N 450 
VAL CB  HB   sing N N 451 
VAL CG1 HG11 sing N N 452 
VAL CG1 HG12 sing N N 453 
VAL CG1 HG13 sing N N 454 
VAL CG2 HG21 sing N N 455 
VAL CG2 HG22 sing N N 456 
VAL CG2 HG23 sing N N 457 
VAL OXT HXT  sing N N 458 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1HM8 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9DQF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010419 
_atom_sites.fract_transf_matrix[1][2]   0.006015 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012031 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003599 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ARG A 1 12  ? 75.795 7.703   27.552  1.00 61.79 ?  2   ARG A N   1 
ATOM   2    C CA  . ARG A 1 12  ? 75.810 7.613   29.010  1.00 57.35 ?  2   ARG A CA  1 
ATOM   3    C C   . ARG A 1 12  ? 75.272 6.263   29.505  1.00 64.72 ?  2   ARG A C   1 
ATOM   4    O O   . ARG A 1 12  ? 75.256 5.998   30.717  1.00 55.79 ?  2   ARG A O   1 
ATOM   5    C CB  . ARG A 1 12  ? 75.001 8.758   29.632  1.00 50.40 ?  2   ARG A CB  1 
ATOM   6    N N   . ARG A 1 13  ? 74.841 5.406   28.574  1.00 55.54 ?  3   ARG A N   1 
ATOM   7    C CA  . ARG A 1 13  ? 74.354 4.073   28.920  1.00 50.53 ?  3   ARG A CA  1 
ATOM   8    C C   . ARG A 1 13  ? 74.898 3.064   27.922  1.00 50.43 ?  3   ARG A C   1 
ATOM   9    O O   . ARG A 1 13  ? 74.792 3.268   26.709  1.00 54.14 ?  3   ARG A O   1 
ATOM   10   C CB  . ARG A 1 13  ? 72.822 4.028   28.956  1.00 46.13 ?  3   ARG A CB  1 
ATOM   11   C CG  . ARG A 1 13  ? 72.235 4.555   30.265  1.00 50.99 ?  3   ARG A CG  1 
ATOM   12   C CD  . ARG A 1 13  ? 70.769 4.907   30.116  1.00 50.11 ?  3   ARG A CD  1 
ATOM   13   N NE  . ARG A 1 13  ? 70.372 6.005   30.987  1.00 57.12 ?  3   ARG A NE  1 
ATOM   14   C CZ  . ARG A 1 13  ? 69.113 6.352   31.223  1.00 64.55 ?  3   ARG A CZ  1 
ATOM   15   N NH1 . ARG A 1 13  ? 68.100 5.710   30.658  1.00 68.17 ?  3   ARG A NH1 1 
ATOM   16   N NH2 . ARG A 1 13  ? 68.862 7.365   32.049  1.00 65.92 ?  3   ARG A NH2 1 
ATOM   17   N N   . HIS A 1 14  ? 75.477 1.980   28.438  1.00 44.76 ?  4   HIS A N   1 
ATOM   18   C CA  . HIS A 1 14  ? 76.142 0.962   27.637  1.00 48.55 ?  4   HIS A CA  1 
ATOM   19   C C   . HIS A 1 14  ? 75.672 -0.416  28.080  1.00 47.15 ?  4   HIS A C   1 
ATOM   20   O O   . HIS A 1 14  ? 75.076 -0.588  29.153  1.00 42.93 ?  4   HIS A O   1 
ATOM   21   C CB  . HIS A 1 14  ? 77.676 1.052   27.764  1.00 48.78 ?  4   HIS A CB  1 
ATOM   22   C CG  . HIS A 1 14  ? 78.188 2.453   27.880  1.00 56.92 ?  4   HIS A CG  1 
ATOM   23   N ND1 . HIS A 1 14  ? 78.490 3.231   26.782  1.00 53.05 ?  4   HIS A ND1 1 
ATOM   24   C CD2 . HIS A 1 14  ? 78.424 3.227   28.967  1.00 53.23 ?  4   HIS A CD2 1 
ATOM   25   C CE1 . HIS A 1 14  ? 78.901 4.419   27.189  1.00 61.73 ?  4   HIS A CE1 1 
ATOM   26   N NE2 . HIS A 1 14  ? 78.865 4.444   28.510  1.00 58.51 ?  4   HIS A NE2 1 
ATOM   27   N N   . ALA A 1 15  ? 75.980 -1.418  27.263  1.00 39.79 ?  5   ALA A N   1 
ATOM   28   C CA  . ALA A 1 15  ? 75.566 -2.770  27.590  1.00 41.75 ?  5   ALA A CA  1 
ATOM   29   C C   . ALA A 1 15  ? 76.595 -3.782  27.108  1.00 41.50 ?  5   ALA A C   1 
ATOM   30   O O   . ALA A 1 15  ? 77.173 -3.641  26.027  1.00 38.93 ?  5   ALA A O   1 
ATOM   31   C CB  . ALA A 1 15  ? 74.196 -3.084  26.990  1.00 39.60 ?  5   ALA A CB  1 
ATOM   32   N N   . ILE A 1 16  ? 76.794 -4.814  27.918  1.00 34.96 ?  6   ILE A N   1 
ATOM   33   C CA  . ILE A 1 16  ? 77.671 -5.928  27.599  1.00 35.37 ?  6   ILE A CA  1 
ATOM   34   C C   . ILE A 1 16  ? 76.814 -7.191  27.597  1.00 41.87 ?  6   ILE A C   1 
ATOM   35   O O   . ILE A 1 16  ? 76.217 -7.543  28.621  1.00 43.91 ?  6   ILE A O   1 
ATOM   36   C CB  . ILE A 1 16  ? 78.832 -6.021  28.600  1.00 37.26 ?  6   ILE A CB  1 
ATOM   37   C CG1 . ILE A 1 16  ? 79.544 -4.659  28.685  1.00 43.76 ?  6   ILE A CG1 1 
ATOM   38   C CG2 . ILE A 1 16  ? 79.804 -7.094  28.170  1.00 37.61 ?  6   ILE A CG2 1 
ATOM   39   C CD1 . ILE A 1 16  ? 80.776 -4.630  29.581  1.00 43.59 ?  6   ILE A CD1 1 
ATOM   40   N N   . ILE A 1 17  ? 76.729 -7.855  26.443  1.00 38.01 ?  7   ILE A N   1 
ATOM   41   C CA  . ILE A 1 17  ? 75.924 -9.064  26.277  1.00 43.04 ?  7   ILE A CA  1 
ATOM   42   C C   . ILE A 1 17  ? 76.862 -10.264 26.195  1.00 39.20 ?  7   ILE A C   1 
ATOM   43   O O   . ILE A 1 17  ? 77.681 -10.358 25.272  1.00 37.23 ?  7   ILE A O   1 
ATOM   44   C CB  . ILE A 1 17  ? 75.040 -8.992  25.022  1.00 42.21 ?  7   ILE A CB  1 
ATOM   45   C CG1 . ILE A 1 17  ? 74.061 -7.833  25.107  1.00 38.62 ?  7   ILE A CG1 1 
ATOM   46   C CG2 . ILE A 1 17  ? 74.288 -10.304 24.832  1.00 39.03 ?  7   ILE A CG2 1 
ATOM   47   C CD1 . ILE A 1 17  ? 73.300 -7.620  23.805  1.00 37.76 ?  7   ILE A CD1 1 
ATOM   48   N N   . LEU A 1 18  ? 76.745 -11.189 27.150  1.00 36.97 ?  8   LEU A N   1 
ATOM   49   C CA  . LEU A 1 18  ? 77.595 -12.375 27.153  1.00 41.57 ?  8   LEU A CA  1 
ATOM   50   C C   . LEU A 1 18  ? 77.033 -13.413 26.188  1.00 41.32 ?  8   LEU A C   1 
ATOM   51   O O   . LEU A 1 18  ? 75.923 -13.919 26.389  1.00 46.06 ?  8   LEU A O   1 
ATOM   52   C CB  . LEU A 1 18  ? 77.723 -12.934 28.567  1.00 36.50 ?  8   LEU A CB  1 
ATOM   53   C CG  . LEU A 1 18  ? 78.124 -11.839 29.568  1.00 44.81 ?  8   LEU A CG  1 
ATOM   54   C CD1 . LEU A 1 18  ? 78.021 -12.287 31.030  1.00 41.55 ?  8   LEU A CD1 1 
ATOM   55   C CD2 . LEU A 1 18  ? 79.519 -11.356 29.232  1.00 44.16 ?  8   LEU A CD2 1 
ATOM   56   N N   . ALA A 1 19  ? 77.790 -13.709 25.130  1.00 41.41 ?  9   ALA A N   1 
ATOM   57   C CA  . ALA A 1 19  ? 77.363 -14.635 24.085  1.00 38.03 ?  9   ALA A CA  1 
ATOM   58   C C   . ALA A 1 19  ? 78.383 -15.736 23.798  1.00 45.80 ?  9   ALA A C   1 
ATOM   59   O O   . ALA A 1 19  ? 78.259 -16.421 22.776  1.00 47.97 ?  9   ALA A O   1 
ATOM   60   C CB  . ALA A 1 19  ? 77.060 -13.871 22.789  1.00 33.48 ?  9   ALA A CB  1 
ATOM   61   N N   . ALA A 1 20  ? 79.383 -15.937 24.656  1.00 50.32 ?  10  ALA A N   1 
ATOM   62   C CA  . ALA A 1 20  ? 80.443 -16.892 24.346  1.00 45.89 ?  10  ALA A CA  1 
ATOM   63   C C   . ALA A 1 20  ? 80.155 -18.293 24.871  1.00 53.45 ?  10  ALA A C   1 
ATOM   64   O O   . ALA A 1 20  ? 80.953 -19.206 24.626  1.00 52.27 ?  10  ALA A O   1 
ATOM   65   C CB  . ALA A 1 20  ? 81.786 -16.402 24.904  1.00 45.87 ?  10  ALA A CB  1 
ATOM   66   N N   . GLY A 1 21  ? 79.044 -18.485 25.581  1.00 53.68 ?  11  GLY A N   1 
ATOM   67   C CA  . GLY A 1 21  ? 78.693 -19.774 26.149  1.00 52.93 ?  11  GLY A CA  1 
ATOM   68   C C   . GLY A 1 21  ? 78.674 -20.917 25.155  1.00 53.28 ?  11  GLY A C   1 
ATOM   69   O O   . GLY A 1 21  ? 78.101 -20.800 24.064  1.00 53.43 ?  11  GLY A O   1 
ATOM   70   N N   . LYS A 1 22  ? 79.317 -22.028 25.529  1.00 57.86 ?  12  LYS A N   1 
ATOM   71   C CA  . LYS A 1 22  ? 79.291 -23.225 24.695  1.00 59.52 ?  12  LYS A CA  1 
ATOM   72   C C   . LYS A 1 22  ? 77.917 -23.886 24.701  1.00 60.14 ?  12  LYS A C   1 
ATOM   73   O O   . LYS A 1 22  ? 77.504 -24.464 23.689  1.00 62.60 ?  12  LYS A O   1 
ATOM   74   C CB  . LYS A 1 22  ? 80.357 -24.210 25.172  1.00 55.99 ?  12  LYS A CB  1 
ATOM   75   N N   . GLY A 1 23  ? 77.193 -23.791 25.817  1.00 59.32 ?  13  GLY A N   1 
ATOM   76   C CA  . GLY A 1 23  ? 75.911 -24.453 25.969  1.00 50.42 ?  13  GLY A CA  1 
ATOM   77   C C   . GLY A 1 23  ? 76.000 -25.932 25.667  1.00 49.10 ?  13  GLY A C   1 
ATOM   78   O O   . GLY A 1 23  ? 75.395 -26.405 24.702  1.00 46.08 ?  13  GLY A O   1 
ATOM   79   N N   . THR A 1 24  ? 76.752 -26.674 26.485  1.00 43.85 ?  14  THR A N   1 
ATOM   80   C CA  . THR A 1 24  ? 77.037 -28.072 26.166  1.00 45.54 ?  14  THR A CA  1 
ATOM   81   C C   . THR A 1 24  ? 75.776 -28.935 26.193  1.00 39.59 ?  14  THR A C   1 
ATOM   82   O O   . THR A 1 24  ? 75.624 -29.831 25.357  1.00 39.43 ?  14  THR A O   1 
ATOM   83   C CB  . THR A 1 24  ? 78.083 -28.617 27.139  1.00 53.95 ?  14  THR A CB  1 
ATOM   84   O OG1 . THR A 1 24  ? 77.601 -28.469 28.484  1.00 63.04 ?  14  THR A OG1 1 
ATOM   85   C CG2 . THR A 1 24  ? 79.386 -27.840 26.993  1.00 43.15 ?  14  THR A CG2 1 
ATOM   86   N N   A ARG A 1 25  ? 74.862 -28.679 27.142  0.98 39.67 ?  15  ARG A N   1 
ATOM   87   C CA  A ARG A 1 25  ? 73.603 -29.415 27.253  0.98 32.71 ?  15  ARG A CA  1 
ATOM   88   C C   A ARG A 1 25  ? 72.695 -29.225 26.042  0.98 36.04 ?  15  ARG A C   1 
ATOM   89   O O   A ARG A 1 25  ? 71.728 -29.978 25.894  0.98 35.93 ?  15  ARG A O   1 
ATOM   90   C CB  . ARG A 1 25  ? 72.824 -28.977 28.492  1.00 45.60 ?  15  ARG A CB  1 
ATOM   91   C CG  . ARG A 1 25  ? 73.591 -28.925 29.805  1.00 45.85 ?  15  ARG A CG  1 
ATOM   92   C CD  . ARG A 1 25  ? 72.928 -29.805 30.846  1.00 52.96 ?  15  ARG A CD  1 
ATOM   93   N NE  . ARG A 1 25  ? 71.557 -29.367 31.105  1.00 57.76 ?  15  ARG A NE  1 
ATOM   94   C CZ  . ARG A 1 25  ? 71.204 -28.342 31.874  1.00 58.97 ?  15  ARG A CZ  1 
ATOM   95   N NH1 . ARG A 1 25  ? 72.100 -27.637 32.547  1.00 56.98 ?  15  ARG A NH1 1 
ATOM   96   N NH2 . ARG A 1 25  ? 69.915 -28.014 31.967  1.00 50.42 ?  15  ARG A NH2 1 
ATOM   97   N N   . MET A 1 26  ? 72.971 -28.236 25.191  1.00 30.70 ?  16  MET A N   1 
ATOM   98   C CA  . MET A 1 26  ? 72.204 -28.032 23.966  1.00 34.84 ?  16  MET A CA  1 
ATOM   99   C C   . MET A 1 26  ? 72.493 -29.119 22.937  1.00 40.56 ?  16  MET A C   1 
ATOM   100  O O   . MET A 1 26  ? 71.709 -29.294 22.000  1.00 35.66 ?  16  MET A O   1 
ATOM   101  C CB  . MET A 1 26  ? 72.545 -26.652 23.388  1.00 37.79 ?  16  MET A CB  1 
ATOM   102  C CG  . MET A 1 26  ? 71.977 -25.457 24.160  1.00 43.23 ?  16  MET A CG  1 
ATOM   103  S SD  . MET A 1 26  ? 70.174 -25.261 24.291  1.00 44.72 ?  16  MET A SD  1 
ATOM   104  C CE  . MET A 1 26  ? 69.806 -24.591 22.688  1.00 40.02 ?  16  MET A CE  1 
ATOM   105  N N   . LYS A 1 27  ? 73.607 -29.844 23.086  1.00 39.55 ?  17  LYS A N   1 
ATOM   106  C CA  . LYS A 1 27  ? 74.069 -30.830 22.106  1.00 36.65 ?  17  LYS A CA  1 
ATOM   107  C C   . LYS A 1 27  ? 74.014 -30.251 20.694  1.00 39.72 ?  17  LYS A C   1 
ATOM   108  O O   . LYS A 1 27  ? 73.370 -30.788 19.789  1.00 36.34 ?  17  LYS A O   1 
ATOM   109  C CB  . LYS A 1 27  ? 73.261 -32.131 22.200  1.00 44.37 ?  17  LYS A CB  1 
ATOM   110  C CG  . LYS A 1 27  ? 73.577 -32.997 23.425  1.00 42.00 ?  17  LYS A CG  1 
ATOM   111  C CD  . LYS A 1 27  ? 73.040 -34.420 23.263  1.00 54.66 ?  17  LYS A CD  1 
ATOM   112  C CE  . LYS A 1 27  ? 74.019 -35.465 23.797  1.00 64.61 ?  17  LYS A CE  1 
ATOM   113  N NZ  . LYS A 1 27  ? 74.314 -36.520 22.767  1.00 45.79 ?  17  LYS A NZ  1 
ATOM   114  N N   . SER A 1 28  ? 74.684 -29.120 20.524  1.00 40.57 ?  18  SER A N   1 
ATOM   115  C CA  . SER A 1 28  ? 74.570 -28.355 19.295  1.00 43.88 ?  18  SER A CA  1 
ATOM   116  C C   . SER A 1 28  ? 75.959 -28.022 18.768  1.00 42.17 ?  18  SER A C   1 
ATOM   117  O O   . SER A 1 28  ? 76.938 -27.962 19.523  1.00 33.48 ?  18  SER A O   1 
ATOM   118  C CB  . SER A 1 28  ? 73.743 -27.066 19.521  1.00 35.08 ?  18  SER A CB  1 
ATOM   119  O OG  . SER A 1 28  ? 73.689 -26.248 18.358  1.00 34.39 ?  18  SER A OG  1 
ATOM   120  N N   . LYS A 1 29  ? 76.031 -27.851 17.447  1.00 38.46 ?  19  LYS A N   1 
ATOM   121  C CA  . LYS A 1 29  ? 77.212 -27.363 16.760  1.00 40.18 ?  19  LYS A CA  1 
ATOM   122  C C   . LYS A 1 29  ? 77.210 -25.847 16.632  1.00 43.52 ?  19  LYS A C   1 
ATOM   123  O O   . LYS A 1 29  ? 78.231 -25.276 16.238  1.00 44.42 ?  19  LYS A O   1 
ATOM   124  C CB  . LYS A 1 29  ? 77.320 -28.020 15.369  1.00 34.44 ?  19  LYS A CB  1 
ATOM   125  N N   . LYS A 1 30  ? 76.101 -25.190 16.985  1.00 40.49 ?  20  LYS A N   1 
ATOM   126  C CA  . LYS A 1 30  ? 75.938 -23.743 16.925  1.00 36.98 ?  20  LYS A CA  1 
ATOM   127  C C   . LYS A 1 30  ? 76.022 -23.140 18.326  1.00 46.87 ?  20  LYS A C   1 
ATOM   128  O O   . LYS A 1 30  ? 75.767 -23.812 19.333  1.00 40.95 ?  20  LYS A O   1 
ATOM   129  C CB  . LYS A 1 30  ? 74.594 -23.378 16.277  1.00 39.19 ?  20  LYS A CB  1 
ATOM   130  N N   . TYR A 1 31  ? 76.381 -21.851 18.386  1.00 38.02 ?  21  TYR A N   1 
ATOM   131  C CA  . TYR A 1 31  ? 76.454 -21.166 19.674  1.00 39.69 ?  21  TYR A CA  1 
ATOM   132  C C   . TYR A 1 31  ? 75.076 -21.105 20.332  1.00 40.89 ?  21  TYR A C   1 
ATOM   133  O O   . TYR A 1 31  ? 74.058 -20.930 19.660  1.00 40.42 ?  21  TYR A O   1 
ATOM   134  C CB  . TYR A 1 31  ? 77.008 -19.750 19.506  1.00 44.76 ?  21  TYR A CB  1 
ATOM   135  C CG  . TYR A 1 31  ? 78.511 -19.681 19.632  1.00 51.28 ?  21  TYR A CG  1 
ATOM   136  C CD1 . TYR A 1 31  ? 79.320 -19.591 18.510  1.00 52.64 ?  21  TYR A CD1 1 
ATOM   137  C CD2 . TYR A 1 31  ? 79.124 -19.752 20.883  1.00 57.10 ?  21  TYR A CD2 1 
ATOM   138  C CE1 . TYR A 1 31  ? 80.703 -19.542 18.626  1.00 58.64 ?  21  TYR A CE1 1 
ATOM   139  C CE2 . TYR A 1 31  ? 80.502 -19.706 21.010  1.00 58.02 ?  21  TYR A CE2 1 
ATOM   140  C CZ  . TYR A 1 31  ? 81.283 -19.600 19.879  1.00 55.15 ?  21  TYR A CZ  1 
ATOM   141  O OH  . TYR A 1 31  ? 82.645 -19.552 20.008  1.00 53.13 ?  21  TYR A OH  1 
ATOM   142  N N   . LYS A 1 32  ? 75.062 -21.216 21.668  1.00 36.99 ?  22  LYS A N   1 
ATOM   143  C CA  . LYS A 1 32  ? 73.803 -21.326 22.406  1.00 41.35 ?  22  LYS A CA  1 
ATOM   144  C C   . LYS A 1 32  ? 72.855 -20.178 22.101  1.00 39.97 ?  22  LYS A C   1 
ATOM   145  O O   . LYS A 1 32  ? 71.658 -20.402 21.868  1.00 41.51 ?  22  LYS A O   1 
ATOM   146  C CB  . LYS A 1 32  ? 74.050 -21.394 23.920  1.00 38.11 ?  22  LYS A CB  1 
ATOM   147  C CG  . LYS A 1 32  ? 72.798 -21.876 24.652  1.00 47.62 ?  22  LYS A CG  1 
ATOM   148  C CD  . LYS A 1 32  ? 72.998 -22.203 26.121  1.00 47.43 ?  22  LYS A CD  1 
ATOM   149  C CE  . LYS A 1 32  ? 73.212 -20.990 26.981  1.00 43.83 ?  22  LYS A CE  1 
ATOM   150  N NZ  . LYS A 1 32  ? 73.181 -21.389 28.433  1.00 36.10 ?  22  LYS A NZ  1 
ATOM   151  N N   . VAL A 1 33  ? 73.361 -18.939 22.108  1.00 34.78 ?  23  VAL A N   1 
ATOM   152  C CA  . VAL A 1 33  ? 72.474 -17.786 21.999  1.00 36.37 ?  23  VAL A CA  1 
ATOM   153  C C   . VAL A 1 33  ? 71.901 -17.610 20.604  1.00 39.92 ?  23  VAL A C   1 
ATOM   154  O O   . VAL A 1 33  ? 71.037 -16.743 20.408  1.00 40.59 ?  23  VAL A O   1 
ATOM   155  C CB  . VAL A 1 33  ? 73.201 -16.502 22.440  1.00 38.91 ?  23  VAL A CB  1 
ATOM   156  C CG1 . VAL A 1 33  ? 73.724 -16.656 23.877  1.00 40.20 ?  23  VAL A CG1 1 
ATOM   157  C CG2 . VAL A 1 33  ? 74.317 -16.135 21.475  1.00 42.84 ?  23  VAL A CG2 1 
ATOM   158  N N   . LEU A 1 34  ? 72.326 -18.424 19.629  1.00 37.87 ?  24  LEU A N   1 
ATOM   159  C CA  . LEU A 1 34  ? 71.750 -18.338 18.288  1.00 34.97 ?  24  LEU A CA  1 
ATOM   160  C C   . LEU A 1 34  ? 70.482 -19.173 18.114  1.00 30.48 ?  24  LEU A C   1 
ATOM   161  O O   . LEU A 1 34  ? 69.770 -18.979 17.127  1.00 39.03 ?  24  LEU A O   1 
ATOM   162  C CB  . LEU A 1 34  ? 72.771 -18.775 17.244  1.00 37.10 ?  24  LEU A CB  1 
ATOM   163  C CG  . LEU A 1 34  ? 73.895 -17.775 16.989  1.00 41.89 ?  24  LEU A CG  1 
ATOM   164  C CD1 . LEU A 1 34  ? 74.816 -18.302 15.907  1.00 44.33 ?  24  LEU A CD1 1 
ATOM   165  C CD2 . LEU A 1 34  ? 73.310 -16.420 16.598  1.00 39.69 ?  24  LEU A CD2 1 
ATOM   166  N N   . HIS A 1 35  ? 70.199 -20.112 19.009  1.00 35.72 ?  25  HIS A N   1 
ATOM   167  C CA  . HIS A 1 35  ? 68.942 -20.855 18.923  1.00 34.12 ?  25  HIS A CA  1 
ATOM   168  C C   . HIS A 1 35  ? 67.761 -19.905 19.118  1.00 39.16 ?  25  HIS A C   1 
ATOM   169  O O   . HIS A 1 35  ? 67.837 -18.911 19.861  1.00 33.16 ?  25  HIS A O   1 
ATOM   170  C CB  . HIS A 1 35  ? 68.929 -21.984 19.955  1.00 33.22 ?  25  HIS A CB  1 
ATOM   171  C CG  . HIS A 1 35  ? 69.971 -23.043 19.702  1.00 40.86 ?  25  HIS A CG  1 
ATOM   172  N ND1 . HIS A 1 35  ? 69.798 -24.066 18.791  1.00 37.86 ?  25  HIS A ND1 1 
ATOM   173  C CD2 . HIS A 1 35  ? 71.244 -23.168 20.162  1.00 50.89 ?  25  HIS A CD2 1 
ATOM   174  C CE1 . HIS A 1 35  ? 70.885 -24.819 18.758  1.00 41.18 ?  25  HIS A CE1 1 
ATOM   175  N NE2 . HIS A 1 35  ? 71.781 -24.293 19.576  1.00 46.02 ?  25  HIS A NE2 1 
ATOM   176  N N   . GLU A 1 36  ? 66.664 -20.207 18.426  1.00 38.77 ?  26  GLU A N   1 
ATOM   177  C CA  . GLU A 1 36  ? 65.580 -19.247 18.261  1.00 35.96 ?  26  GLU A CA  1 
ATOM   178  C C   . GLU A 1 36  ? 64.444 -19.479 19.241  1.00 33.42 ?  26  GLU A C   1 
ATOM   179  O O   . GLU A 1 36  ? 64.159 -20.610 19.650  1.00 35.35 ?  26  GLU A O   1 
ATOM   180  C CB  . GLU A 1 36  ? 65.009 -19.306 16.843  1.00 32.58 ?  26  GLU A CB  1 
ATOM   181  C CG  . GLU A 1 36  ? 66.016 -18.965 15.783  1.00 37.78 ?  26  GLU A CG  1 
ATOM   182  C CD  . GLU A 1 36  ? 65.393 -18.954 14.404  1.00 43.71 ?  26  GLU A CD  1 
ATOM   183  O OE1 . GLU A 1 36  ? 64.198 -19.290 14.290  1.00 42.11 ?  26  GLU A OE1 1 
ATOM   184  O OE2 . GLU A 1 36  ? 66.100 -18.618 13.438  1.00 54.30 ?  26  GLU A OE2 1 
ATOM   185  N N   . VAL A 1 37  ? 63.787 -18.375 19.597  1.00 32.45 ?  27  VAL A N   1 
ATOM   186  C CA  . VAL A 1 37  ? 62.483 -18.354 20.250  1.00 35.83 ?  27  VAL A CA  1 
ATOM   187  C C   . VAL A 1 37  ? 61.621 -17.397 19.444  1.00 36.60 ?  27  VAL A C   1 
ATOM   188  O O   . VAL A 1 37  ? 62.099 -16.335 19.029  1.00 36.73 ?  27  VAL A O   1 
ATOM   189  C CB  . VAL A 1 37  ? 62.572 -17.895 21.726  1.00 36.91 ?  27  VAL A CB  1 
ATOM   190  C CG1 . VAL A 1 37  ? 61.181 -17.538 22.292  1.00 35.86 ?  27  VAL A CG1 1 
ATOM   191  C CG2 . VAL A 1 37  ? 63.235 -18.971 22.582  1.00 41.54 ?  27  VAL A CG2 1 
ATOM   192  N N   . ALA A 1 38  ? 60.370 -17.786 19.186  1.00 33.42 ?  28  ALA A N   1 
ATOM   193  C CA  . ALA A 1 38  ? 59.413 -16.945 18.459  1.00 34.59 ?  28  ALA A CA  1 
ATOM   194  C C   . ALA A 1 38  ? 60.019 -16.400 17.167  1.00 39.28 ?  28  ALA A C   1 
ATOM   195  O O   . ALA A 1 38  ? 59.804 -15.243 16.786  1.00 37.78 ?  28  ALA A O   1 
ATOM   196  C CB  . ALA A 1 38  ? 58.886 -15.806 19.341  1.00 37.95 ?  28  ALA A CB  1 
ATOM   197  N N   . GLY A 1 39  ? 60.807 -17.236 16.501  1.00 33.62 ?  29  GLY A N   1 
ATOM   198  C CA  . GLY A 1 39  ? 61.319 -16.920 15.187  1.00 37.63 ?  29  GLY A CA  1 
ATOM   199  C C   . GLY A 1 39  ? 62.587 -16.091 15.128  1.00 40.41 ?  29  GLY A C   1 
ATOM   200  O O   . GLY A 1 39  ? 62.959 -15.659 14.030  1.00 34.02 ?  29  GLY A O   1 
ATOM   201  N N   . LYS A 1 40  ? 63.272 -15.861 16.251  1.00 29.82 ?  30  LYS A N   1 
ATOM   202  C CA  . LYS A 1 40  ? 64.509 -15.094 16.196  1.00 37.42 ?  30  LYS A CA  1 
ATOM   203  C C   . LYS A 1 40  ? 65.481 -15.558 17.278  1.00 36.76 ?  30  LYS A C   1 
ATOM   204  O O   . LYS A 1 40  ? 65.053 -16.020 18.342  1.00 36.86 ?  30  LYS A O   1 
ATOM   205  C CB  . LYS A 1 40  ? 64.207 -13.582 16.295  1.00 37.82 ?  30  LYS A CB  1 
ATOM   206  C CG  . LYS A 1 40  ? 64.035 -13.034 17.679  1.00 46.25 ?  30  LYS A CG  1 
ATOM   207  C CD  . LYS A 1 40  ? 64.212 -11.513 17.710  1.00 51.09 ?  30  LYS A CD  1 
ATOM   208  C CE  . LYS A 1 40  ? 63.266 -10.781 16.763  1.00 47.51 ?  30  LYS A CE  1 
ATOM   209  N NZ  . LYS A 1 40  ? 62.994 -9.393  17.238  1.00 44.56 ?  30  LYS A NZ  1 
ATOM   210  N N   . PRO A 1 41  ? 66.789 -15.474 17.020  1.00 37.58 ?  31  PRO A N   1 
ATOM   211  C CA  . PRO A 1 41  ? 67.789 -15.953 17.993  1.00 36.44 ?  31  PRO A CA  1 
ATOM   212  C C   . PRO A 1 41  ? 67.635 -15.296 19.358  1.00 33.68 ?  31  PRO A C   1 
ATOM   213  O O   . PRO A 1 41  ? 67.281 -14.125 19.461  1.00 33.24 ?  31  PRO A O   1 
ATOM   214  C CB  . PRO A 1 41  ? 69.115 -15.556 17.339  1.00 36.69 ?  31  PRO A CB  1 
ATOM   215  C CG  . PRO A 1 41  ? 68.798 -15.658 15.857  1.00 42.90 ?  31  PRO A CG  1 
ATOM   216  C CD  . PRO A 1 41  ? 67.415 -15.054 15.752  1.00 36.61 ?  31  PRO A CD  1 
ATOM   217  N N   . MET A 1 42  ? 67.937 -16.060 20.416  1.00 32.55 ?  32  MET A N   1 
ATOM   218  C CA  . MET A 1 42  ? 67.790 -15.510 21.763  1.00 37.59 ?  32  MET A CA  1 
ATOM   219  C C   . MET A 1 42  ? 68.611 -14.236 21.952  1.00 37.96 ?  32  MET A C   1 
ATOM   220  O O   . MET A 1 42  ? 68.189 -13.321 22.671  1.00 37.24 ?  32  MET A O   1 
ATOM   221  C CB  . MET A 1 42  ? 68.178 -16.523 22.848  1.00 34.31 ?  32  MET A CB  1 
ATOM   222  C CG  . MET A 1 42  ? 67.205 -17.709 23.001  1.00 34.21 ?  32  MET A CG  1 
ATOM   223  S SD  . MET A 1 42  ? 67.615 -18.824 24.354  1.00 35.69 ?  32  MET A SD  1 
ATOM   224  C CE  . MET A 1 42  ? 69.122 -19.588 23.751  1.00 38.51 ?  32  MET A CE  1 
ATOM   225  N N   . VAL A 1 43  ? 69.794 -14.166 21.341  1.00 34.18 ?  33  VAL A N   1 
ATOM   226  C CA  . VAL A 1 43  ? 70.631 -12.980 21.529  1.00 40.45 ?  33  VAL A CA  1 
ATOM   227  C C   . VAL A 1 43  ? 69.979 -11.743 20.905  1.00 42.51 ?  33  VAL A C   1 
ATOM   228  O O   . VAL A 1 43  ? 70.192 -10.614 21.374  1.00 42.21 ?  33  VAL A O   1 
ATOM   229  C CB  . VAL A 1 43  ? 72.045 -13.248 20.974  1.00 35.88 ?  33  VAL A CB  1 
ATOM   230  C CG1 . VAL A 1 43  ? 72.021 -13.418 19.459  1.00 37.29 ?  33  VAL A CG1 1 
ATOM   231  C CG2 . VAL A 1 43  ? 73.004 -12.134 21.386  1.00 36.82 ?  33  VAL A CG2 1 
ATOM   232  N N   . GLU A 1 44  ? 69.161 -11.928 19.860  1.00 37.52 ?  34  GLU A N   1 
ATOM   233  C CA  . GLU A 1 44  ? 68.459 -10.793 19.262  1.00 42.19 ?  34  GLU A CA  1 
ATOM   234  C C   . GLU A 1 44  ? 67.361 -10.277 20.185  1.00 36.90 ?  34  GLU A C   1 
ATOM   235  O O   . GLU A 1 44  ? 67.146 -9.066  20.281  1.00 36.70 ?  34  GLU A O   1 
ATOM   236  C CB  . GLU A 1 44  ? 67.851 -11.188 17.912  1.00 42.25 ?  34  GLU A CB  1 
ATOM   237  C CG  . GLU A 1 44  ? 67.369 -10.009 17.065  1.00 44.90 ?  34  GLU A CG  1 
ATOM   238  C CD  . GLU A 1 44  ? 67.222 -10.367 15.581  1.00 47.90 ?  34  GLU A CD  1 
ATOM   239  O OE1 . GLU A 1 44  ? 66.984 -11.552 15.275  1.00 52.67 ?  34  GLU A OE1 1 
ATOM   240  O OE2 . GLU A 1 44  ? 67.318 -9.475  14.719  1.00 50.49 -1 34  GLU A OE2 1 
ATOM   241  N N   . HIS A 1 45  ? 66.614 -11.183 20.831  1.00 38.32 ?  35  HIS A N   1 
ATOM   242  C CA  . HIS A 1 45  ? 65.639 -10.753 21.834  1.00 37.03 ?  35  HIS A CA  1 
ATOM   243  C C   . HIS A 1 45  ? 66.311 -9.876  22.888  1.00 39.01 ?  35  HIS A C   1 
ATOM   244  O O   . HIS A 1 45  ? 65.785 -8.825  23.270  1.00 37.24 ?  35  HIS A O   1 
ATOM   245  C CB  . HIS A 1 45  ? 64.993 -11.959 22.529  1.00 37.11 ?  35  HIS A CB  1 
ATOM   246  C CG  . HIS A 1 45  ? 64.007 -12.712 21.694  1.00 35.19 ?  35  HIS A CG  1 
ATOM   247  N ND1 . HIS A 1 45  ? 62.719 -12.266 21.477  1.00 39.64 ?  35  HIS A ND1 1 
ATOM   248  C CD2 . HIS A 1 45  ? 64.113 -13.901 21.048  1.00 34.89 ?  35  HIS A CD2 1 
ATOM   249  C CE1 . HIS A 1 45  ? 62.079 -13.140 20.718  1.00 39.13 ?  35  HIS A CE1 1 
ATOM   250  N NE2 . HIS A 1 45  ? 62.901 -14.139 20.442  1.00 39.33 ?  35  HIS A NE2 1 
ATOM   251  N N   . VAL A 1 46  ? 67.458 -10.331 23.405  1.00 33.16 ?  36  VAL A N   1 
ATOM   252  C CA  . VAL A 1 46  ? 68.174 -9.564  24.422  1.00 36.20 ?  36  VAL A CA  1 
ATOM   253  C C   . VAL A 1 46  ? 68.621 -8.226  23.861  1.00 33.41 ?  36  VAL A C   1 
ATOM   254  O O   . VAL A 1 46  ? 68.428 -7.178  24.489  1.00 33.07 ?  36  VAL A O   1 
ATOM   255  C CB  . VAL A 1 46  ? 69.363 -10.367 24.977  1.00 37.31 ?  36  VAL A CB  1 
ATOM   256  C CG1 . VAL A 1 46  ? 69.971 -9.621  26.149  1.00 32.71 ?  36  VAL A CG1 1 
ATOM   257  C CG2 . VAL A 1 46  ? 68.870 -11.731 25.471  1.00 35.37 ?  36  VAL A CG2 1 
ATOM   258  N N   . LEU A 1 47  ? 69.233 -8.240  22.677  1.00 30.54 ?  37  LEU A N   1 
ATOM   259  C CA  . LEU A 1 47  ? 69.646 -6.984  22.058  1.00 37.14 ?  37  LEU A CA  1 
ATOM   260  C C   . LEU A 1 47  ? 68.493 -5.985  21.986  1.00 40.99 ?  37  LEU A C   1 
ATOM   261  O O   . LEU A 1 47  ? 68.643 -4.816  22.372  1.00 34.55 ?  37  LEU A O   1 
ATOM   262  C CB  . LEU A 1 47  ? 70.227 -7.237  20.662  1.00 36.79 ?  37  LEU A CB  1 
ATOM   263  C CG  . LEU A 1 47  ? 70.821 -5.946  20.059  1.00 47.43 ?  37  LEU A CG  1 
ATOM   264  C CD1 . LEU A 1 47  ? 72.325 -5.802  20.291  1.00 47.92 ?  37  LEU A CD1 1 
ATOM   265  C CD2 . LEU A 1 47  ? 70.500 -5.863  18.571  1.00 58.32 ?  37  LEU A CD2 1 
ATOM   266  N N   . GLU A 1 48  ? 67.323 -6.431  21.507  1.00 42.17 ?  38  GLU A N   1 
ATOM   267  C CA  . GLU A 1 48  ? 66.206 -5.501  21.361  1.00 36.59 ?  38  GLU A CA  1 
ATOM   268  C C   . GLU A 1 48  ? 65.724 -4.991  22.709  1.00 41.42 ?  38  GLU A C   1 
ATOM   269  O O   . GLU A 1 48  ? 65.384 -3.809  22.836  1.00 40.91 ?  38  GLU A O   1 
ATOM   270  C CB  . GLU A 1 48  ? 65.054 -6.136  20.582  1.00 42.21 ?  38  GLU A CB  1 
ATOM   271  C CG  . GLU A 1 48  ? 65.455 -6.636  19.202  1.00 47.41 ?  38  GLU A CG  1 
ATOM   272  C CD  . GLU A 1 48  ? 65.619 -5.505  18.198  1.00 59.10 ?  38  GLU A CD  1 
ATOM   273  O OE1 . GLU A 1 48  ? 65.426 -4.326  18.579  1.00 55.11 ?  38  GLU A OE1 1 
ATOM   274  O OE2 . GLU A 1 48  ? 65.960 -5.795  17.028  1.00 66.10 ?  38  GLU A OE2 1 
ATOM   275  N N   A SER A 1 49  ? 65.679 -5.857  23.730  1.00 34.18 ?  39  SER A N   1 
ATOM   276  C CA  A SER A 1 49  ? 65.327 -5.359  25.058  1.00 41.63 ?  39  SER A CA  1 
ATOM   277  C C   A SER A 1 49  ? 66.358 -4.347  25.539  1.00 35.48 ?  39  SER A C   1 
ATOM   278  O O   A SER A 1 49  ? 66.005 -3.310  26.112  1.00 38.98 ?  39  SER A O   1 
ATOM   279  C CB  . SER A 1 49  ? 65.193 -6.508  26.064  1.00 41.72 ?  39  SER A CB  1 
ATOM   280  O OG  . SER A 1 49  ? 64.072 -7.349  25.792  1.00 40.07 ?  39  SER A OG  1 
ATOM   281  N N   . VAL A 1 50  ? 67.636 -4.617  25.283  1.00 38.32 ?  40  VAL A N   1 
ATOM   282  C CA  . VAL A 1 50  ? 68.694 -3.711  25.724  1.00 42.61 ?  40  VAL A CA  1 
ATOM   283  C C   . VAL A 1 50  ? 68.566 -2.360  25.017  1.00 47.41 ?  40  VAL A C   1 
ATOM   284  O O   . VAL A 1 50  ? 68.510 -1.300  25.658  1.00 40.17 ?  40  VAL A O   1 
ATOM   285  C CB  . VAL A 1 50  ? 70.073 -4.357  25.484  1.00 41.68 ?  40  VAL A CB  1 
ATOM   286  C CG1 . VAL A 1 50  ? 71.157 -3.294  25.410  1.00 42.36 ?  40  VAL A CG1 1 
ATOM   287  C CG2 . VAL A 1 50  ? 70.384 -5.409  26.562  1.00 39.16 ?  40  VAL A CG2 1 
ATOM   288  N N   . LYS A 1 51  ? 68.497 -2.380  23.679  1.00 42.03 ?  41  LYS A N   1 
ATOM   289  C CA  . LYS A 1 51  ? 68.352 -1.134  22.931  1.00 37.74 ?  41  LYS A CA  1 
ATOM   290  C C   . LYS A 1 51  ? 67.061 -0.416  23.316  1.00 45.76 ?  41  LYS A C   1 
ATOM   291  O O   . LYS A 1 51  ? 67.053 0.808   23.489  1.00 47.01 ?  41  LYS A O   1 
ATOM   292  C CB  . LYS A 1 51  ? 68.383 -1.415  21.424  1.00 46.16 ?  41  LYS A CB  1 
ATOM   293  C CG  . LYS A 1 51  ? 69.738 -1.876  20.869  1.00 47.27 ?  41  LYS A CG  1 
ATOM   294  C CD  . LYS A 1 51  ? 70.901 -0.967  21.229  1.00 51.27 ?  41  LYS A CD  1 
ATOM   295  C CE  . LYS A 1 51  ? 70.797 0.418   20.592  1.00 63.04 ?  41  LYS A CE  1 
ATOM   296  N NZ  . LYS A 1 51  ? 72.055 0.790   19.850  1.00 63.14 ?  41  LYS A NZ  1 
ATOM   297  N N   . GLY A 1 52  ? 65.964 -1.165  23.487  1.00 42.90 ?  42  GLY A N   1 
ATOM   298  C CA  . GLY A 1 52  ? 64.693 -0.567  23.863  1.00 45.78 ?  42  GLY A CA  1 
ATOM   299  C C   . GLY A 1 52  ? 64.691 0.063   25.243  1.00 51.86 ?  42  GLY A C   1 
ATOM   300  O O   . GLY A 1 52  ? 63.779 0.832   25.569  1.00 46.12 ?  42  GLY A O   1 
ATOM   301  N N   . SER A 1 53  ? 65.688 -0.248  26.062  1.00 49.12 ?  43  SER A N   1 
ATOM   302  C CA  . SER A 1 53  ? 65.827 0.310   27.399  1.00 48.45 ?  43  SER A CA  1 
ATOM   303  C C   . SER A 1 53  ? 66.573 1.646   27.429  1.00 50.73 ?  43  SER A C   1 
ATOM   304  O O   . SER A 1 53  ? 66.726 2.236   28.507  1.00 52.29 ?  43  SER A O   1 
ATOM   305  C CB  . SER A 1 53  ? 66.529 -0.721  28.301  1.00 44.76 ?  43  SER A CB  1 
ATOM   306  O OG  . SER A 1 53  ? 67.924 -0.488  28.392  1.00 44.79 ?  43  SER A OG  1 
ATOM   307  N N   A GLY A 1 54  ? 67.046 2.137   26.290  1.00 49.08 ?  44  GLY A N   1 
ATOM   308  C CA  A GLY A 1 54  ? 67.787 3.383   26.254  1.00 44.37 ?  44  GLY A CA  1 
ATOM   309  C C   A GLY A 1 54  ? 69.285 3.244   26.152  1.00 46.80 ?  44  GLY A C   1 
ATOM   310  O O   A GLY A 1 54  ? 69.997 4.247   26.281  1.00 51.57 ?  44  GLY A O   1 
ATOM   311  N N   . VAL A 1 55  ? 69.789 2.044   25.932  1.00 45.04 ?  45  VAL A N   1 
ATOM   312  C CA  . VAL A 1 55  ? 71.226 1.848   25.805  1.00 48.86 ?  45  VAL A CA  1 
ATOM   313  C C   . VAL A 1 55  ? 71.670 2.282   24.415  1.00 51.69 ?  45  VAL A C   1 
ATOM   314  O O   . VAL A 1 55  ? 71.050 1.919   23.410  1.00 47.25 ?  45  VAL A O   1 
ATOM   315  C CB  . VAL A 1 55  ? 71.594 0.384   26.082  1.00 45.67 ?  45  VAL A CB  1 
ATOM   316  C CG1 . VAL A 1 55  ? 73.070 0.141   25.794  1.00 47.87 ?  45  VAL A CG1 1 
ATOM   317  C CG2 . VAL A 1 55  ? 71.258 0.040   27.525  1.00 49.93 ?  45  VAL A CG2 1 
ATOM   318  N N   . ASP A 1 56  ? 72.748 3.066   24.354  1.00 49.93 ?  46  ASP A N   1 
ATOM   319  C CA  . ASP A 1 56  ? 73.287 3.520   23.077  1.00 55.87 ?  46  ASP A CA  1 
ATOM   320  C C   . ASP A 1 56  ? 74.293 2.518   22.518  1.00 61.59 ?  46  ASP A C   1 
ATOM   321  O O   . ASP A 1 56  ? 74.109 1.983   21.419  1.00 69.52 ?  46  ASP A O   1 
ATOM   322  C CB  . ASP A 1 56  ? 73.924 4.907   23.238  1.00 64.17 ?  46  ASP A CB  1 
ATOM   323  N N   . GLN A 1 57  ? 75.345 2.232   23.274  1.00 54.02 ?  47  GLN A N   1 
ATOM   324  C CA  . GLN A 1 57  ? 76.440 1.403   22.799  1.00 55.39 ?  47  GLN A CA  1 
ATOM   325  C C   . GLN A 1 57  ? 76.299 -0.000  23.368  1.00 50.20 ?  47  GLN A C   1 
ATOM   326  O O   . GLN A 1 57  ? 76.089 -0.167  24.575  1.00 55.38 ?  47  GLN A O   1 
ATOM   327  C CB  . GLN A 1 57  ? 77.780 2.010   23.211  1.00 59.59 ?  47  GLN A CB  1 
ATOM   328  C CG  . GLN A 1 57  ? 78.282 3.084   22.268  1.00 74.19 ?  47  GLN A CG  1 
ATOM   329  C CD  . GLN A 1 57  ? 79.744 3.408   22.493  1.00 79.47 ?  47  GLN A CD  1 
ATOM   330  O OE1 . GLN A 1 57  ? 80.317 4.259   21.809  1.00 91.18 ?  47  GLN A OE1 1 
ATOM   331  N NE2 . GLN A 1 57  ? 80.362 2.722   23.451  1.00 70.00 ?  47  GLN A NE2 1 
ATOM   332  N N   . VAL A 1 58  ? 76.430 -1.004  22.509  1.00 45.75 ?  48  VAL A N   1 
ATOM   333  C CA  . VAL A 1 58  ? 76.312 -2.403  22.907  1.00 44.04 ?  48  VAL A CA  1 
ATOM   334  C C   . VAL A 1 58  ? 77.579 -3.141  22.493  1.00 48.09 ?  48  VAL A C   1 
ATOM   335  O O   . VAL A 1 58  ? 78.018 -3.040  21.339  1.00 43.48 ?  48  VAL A O   1 
ATOM   336  C CB  . VAL A 1 58  ? 75.070 -3.064  22.280  1.00 45.93 ?  48  VAL A CB  1 
ATOM   337  C CG1 . VAL A 1 58  ? 75.044 -4.573  22.591  1.00 40.81 ?  48  VAL A CG1 1 
ATOM   338  C CG2 . VAL A 1 58  ? 73.807 -2.374  22.737  1.00 43.35 ?  48  VAL A CG2 1 
ATOM   339  N N   . VAL A 1 59  ? 78.165 -3.883  23.430  1.00 41.97 ?  49  VAL A N   1 
ATOM   340  C CA  . VAL A 1 59  ? 79.255 -4.808  23.142  1.00 42.71 ?  49  VAL A CA  1 
ATOM   341  C C   . VAL A 1 59  ? 78.768 -6.217  23.413  1.00 39.66 ?  49  VAL A C   1 
ATOM   342  O O   . VAL A 1 59  ? 78.199 -6.487  24.476  1.00 43.15 ?  49  VAL A O   1 
ATOM   343  C CB  . VAL A 1 59  ? 80.510 -4.512  23.979  1.00 45.02 ?  49  VAL A CB  1 
ATOM   344  C CG1 . VAL A 1 59  ? 81.648 -5.431  23.538  1.00 39.18 ?  49  VAL A CG1 1 
ATOM   345  C CG2 . VAL A 1 59  ? 80.905 -3.048  23.832  1.00 45.42 ?  49  VAL A CG2 1 
ATOM   346  N N   . THR A 1 60  ? 78.992 -7.112  22.460  1.00 40.22 ?  50  THR A N   1 
ATOM   347  C CA  . THR A 1 60  ? 78.700 -8.529  22.629  1.00 42.51 ?  50  THR A CA  1 
ATOM   348  C C   . THR A 1 60  ? 80.008 -9.312  22.708  1.00 42.21 ?  50  THR A C   1 
ATOM   349  O O   . THR A 1 60  ? 80.872 -9.176  21.837  1.00 44.59 ?  50  THR A O   1 
ATOM   350  C CB  . THR A 1 60  ? 77.812 -9.038  21.486  1.00 39.92 ?  50  THR A CB  1 
ATOM   351  O OG1 . THR A 1 60  ? 76.606 -8.263  21.444  1.00 40.02 ?  50  THR A OG1 1 
ATOM   352  C CG2 . THR A 1 60  ? 77.459 -10.516 21.669  1.00 37.71 ?  50  THR A CG2 1 
ATOM   353  N N   . ILE A 1 61  ? 80.154 -10.113 23.762  1.00 41.57 ?  51  ILE A N   1 
ATOM   354  C CA  . ILE A 1 61  ? 81.342 -10.939 23.977  1.00 44.25 ?  51  ILE A CA  1 
ATOM   355  C C   . ILE A 1 61  ? 81.161 -12.265 23.247  1.00 50.89 ?  51  ILE A C   1 
ATOM   356  O O   . ILE A 1 61  ? 80.198 -12.994 23.514  1.00 42.31 ?  51  ILE A O   1 
ATOM   357  C CB  . ILE A 1 61  ? 81.583 -11.168 25.477  1.00 46.15 ?  51  ILE A CB  1 
ATOM   358  C CG1 . ILE A 1 61  ? 81.424 -9.847  26.249  1.00 48.75 ?  51  ILE A CG1 1 
ATOM   359  C CG2 . ILE A 1 61  ? 82.906 -11.922 25.734  1.00 47.40 ?  51  ILE A CG2 1 
ATOM   360  C CD1 . ILE A 1 61  ? 82.502 -8.802  25.950  1.00 43.33 ?  51  ILE A CD1 1 
ATOM   361  N N   . VAL A 1 62  ? 82.091 -12.590 22.342  1.00 47.69 ?  52  VAL A N   1 
ATOM   362  C CA  . VAL A 1 62  ? 81.982 -13.784 21.507  1.00 48.84 ?  52  VAL A CA  1 
ATOM   363  C C   . VAL A 1 62  ? 83.199 -14.688 21.705  1.00 52.91 ?  52  VAL A C   1 
ATOM   364  O O   . VAL A 1 62  ? 84.220 -14.293 22.268  1.00 51.41 ?  52  VAL A O   1 
ATOM   365  C CB  . VAL A 1 62  ? 81.805 -13.449 20.010  1.00 51.48 ?  52  VAL A CB  1 
ATOM   366  C CG1 . VAL A 1 62  ? 80.550 -12.614 19.770  1.00 45.54 ?  52  VAL A CG1 1 
ATOM   367  C CG2 . VAL A 1 62  ? 83.033 -12.717 19.480  1.00 51.23 ?  52  VAL A CG2 1 
ATOM   368  N N   . GLY A 1 63  ? 83.073 -15.922 21.209  1.00 51.86 ?  53  GLY A N   1 
ATOM   369  C CA  . GLY A 1 63  ? 84.124 -16.907 21.281  1.00 52.99 ?  53  GLY A CA  1 
ATOM   370  C C   . GLY A 1 63  ? 84.729 -17.226 19.928  1.00 54.00 ?  53  GLY A C   1 
ATOM   371  O O   . GLY A 1 63  ? 84.573 -16.484 18.948  1.00 55.48 ?  53  GLY A O   1 
ATOM   372  N N   . HIS A 1 64  ? 85.438 -18.352 19.871  1.00 53.17 ?  54  HIS A N   1 
ATOM   373  C CA  . HIS A 1 64  ? 86.010 -18.802 18.609  1.00 67.53 ?  54  HIS A CA  1 
ATOM   374  C C   . HIS A 1 64  ? 84.908 -19.164 17.624  1.00 66.12 ?  54  HIS A C   1 
ATOM   375  O O   . HIS A 1 64  ? 83.859 -19.695 18.001  1.00 61.70 ?  54  HIS A O   1 
ATOM   376  C CB  . HIS A 1 64  ? 86.919 -20.015 18.815  1.00 67.31 ?  54  HIS A CB  1 
ATOM   377  C CG  . HIS A 1 64  ? 88.116 -19.740 19.668  1.00 64.78 ?  54  HIS A CG  1 
ATOM   378  N ND1 . HIS A 1 64  ? 89.358 -19.464 19.136  1.00 65.84 ?  54  HIS A ND1 1 
ATOM   379  C CD2 . HIS A 1 64  ? 88.269 -19.721 21.014  1.00 68.14 ?  54  HIS A CD2 1 
ATOM   380  C CE1 . HIS A 1 64  ? 90.221 -19.273 20.118  1.00 66.92 ?  54  HIS A CE1 1 
ATOM   381  N NE2 . HIS A 1 64  ? 89.587 -19.423 21.267  1.00 72.54 ?  54  HIS A NE2 1 
ATOM   382  N N   . GLY A 1 65  ? 85.162 -18.880 16.349  1.00 66.02 ?  55  GLY A N   1 
ATOM   383  C CA  . GLY A 1 65  ? 84.215 -19.227 15.299  1.00 61.22 ?  55  GLY A CA  1 
ATOM   384  C C   . GLY A 1 65  ? 82.853 -18.590 15.467  1.00 63.76 ?  55  GLY A C   1 
ATOM   385  O O   . GLY A 1 65  ? 81.827 -19.263 15.298  1.00 59.96 ?  55  GLY A O   1 
ATOM   386  N N   . ALA A 1 66  ? 82.820 -17.299 15.802  1.00 61.00 ?  56  ALA A N   1 
ATOM   387  C CA  . ALA A 1 66  ? 81.580 -16.582 16.066  1.00 57.83 ?  56  ALA A CA  1 
ATOM   388  C C   . ALA A 1 66  ? 81.117 -15.772 14.863  1.00 60.71 ?  56  ALA A C   1 
ATOM   389  O O   . ALA A 1 66  ? 80.442 -14.751 15.025  1.00 56.02 ?  56  ALA A O   1 
ATOM   390  C CB  . ALA A 1 66  ? 81.746 -15.677 17.285  1.00 52.52 ?  56  ALA A CB  1 
ATOM   391  N N   . GLU A 1 67  ? 81.479 -16.201 13.652  1.00 59.13 ?  57  GLU A N   1 
ATOM   392  C CA  . GLU A 1 67  ? 81.046 -15.477 12.463  1.00 60.15 ?  57  GLU A CA  1 
ATOM   393  C C   . GLU A 1 67  ? 79.527 -15.394 12.399  1.00 57.76 ?  57  GLU A C   1 
ATOM   394  O O   . GLU A 1 67  ? 78.964 -14.354 12.040  1.00 54.98 ?  57  GLU A O   1 
ATOM   395  C CB  . GLU A 1 67  ? 81.592 -16.154 11.205  1.00 54.99 ?  57  GLU A CB  1 
ATOM   396  C CG  . GLU A 1 67  ? 83.112 -16.194 11.117  1.00 67.64 ?  57  GLU A CG  1 
ATOM   397  C CD  . GLU A 1 67  ? 83.720 -17.353 11.900  1.00 74.49 ?  57  GLU A CD  1 
ATOM   398  O OE1 . GLU A 1 67  ? 82.953 -18.212 12.395  1.00 78.63 ?  57  GLU A OE1 1 
ATOM   399  O OE2 . GLU A 1 67  ? 84.965 -17.412 12.011  1.00 76.92 ?  57  GLU A OE2 1 
ATOM   400  N N   . SER A 1 68  ? 78.846 -16.481 12.762  1.00 55.69 ?  58  SER A N   1 
ATOM   401  C CA  . SER A 1 68  ? 77.392 -16.505 12.684  1.00 57.06 ?  58  SER A CA  1 
ATOM   402  C C   . SER A 1 68  ? 76.762 -15.507 13.652  1.00 52.14 ?  58  SER A C   1 
ATOM   403  O O   . SER A 1 68  ? 75.758 -14.866 13.319  1.00 50.38 ?  58  SER A O   1 
ATOM   404  C CB  . SER A 1 68  ? 76.898 -17.930 12.943  1.00 60.51 ?  58  SER A CB  1 
ATOM   405  O OG  . SER A 1 68  ? 77.758 -18.591 13.861  1.00 68.17 ?  58  SER A OG  1 
ATOM   406  N N   . VAL A 1 69  ? 77.336 -15.354 14.851  1.00 54.30 ?  59  VAL A N   1 
ATOM   407  C CA  . VAL A 1 69  ? 76.826 -14.357 15.794  1.00 46.79 ?  59  VAL A CA  1 
ATOM   408  C C   . VAL A 1 69  ? 77.004 -12.957 15.227  1.00 52.62 ?  59  VAL A C   1 
ATOM   409  O O   . VAL A 1 69  ? 76.067 -12.148 15.204  1.00 44.94 ?  59  VAL A O   1 
ATOM   410  C CB  . VAL A 1 69  ? 77.522 -14.486 17.162  1.00 50.77 ?  59  VAL A CB  1 
ATOM   411  C CG1 . VAL A 1 69  ? 77.043 -13.385 18.091  1.00 41.18 ?  59  VAL A CG1 1 
ATOM   412  C CG2 . VAL A 1 69  ? 77.286 -15.864 17.782  1.00 50.76 ?  59  VAL A CG2 1 
ATOM   413  N N   . LYS A 1 70  ? 78.223 -12.645 14.782  1.00 50.14 ?  60  LYS A N   1 
ATOM   414  C CA  . LYS A 1 70  ? 78.483 -11.334 14.198  1.00 55.59 ?  60  LYS A CA  1 
ATOM   415  C C   . LYS A 1 70  ? 77.676 -11.146 12.922  1.00 54.96 ?  60  LYS A C   1 
ATOM   416  O O   . LYS A 1 70  ? 77.062 -10.091 12.713  1.00 56.61 ?  60  LYS A O   1 
ATOM   417  C CB  . LYS A 1 70  ? 79.985 -11.177 13.949  1.00 53.40 ?  60  LYS A CB  1 
ATOM   418  C CG  . LYS A 1 70  ? 80.802 -11.528 15.185  1.00 58.60 ?  60  LYS A CG  1 
ATOM   419  C CD  . LYS A 1 70  ? 82.199 -10.930 15.200  1.00 57.24 ?  60  LYS A CD  1 
ATOM   420  C CE  . LYS A 1 70  ? 83.113 -11.652 14.234  1.00 65.22 ?  60  LYS A CE  1 
ATOM   421  N NZ  . LYS A 1 70  ? 84.546 -11.306 14.492  1.00 70.30 ?  60  LYS A NZ  1 
ATOM   422  N N   . GLY A 1 71  ? 77.627 -12.180 12.081  1.00 56.44 ?  61  GLY A N   1 
ATOM   423  C CA  . GLY A 1 71  ? 76.831 -12.094 10.871  1.00 63.71 ?  61  GLY A CA  1 
ATOM   424  C C   . GLY A 1 71  ? 75.376 -11.774 11.152  1.00 58.98 ?  61  GLY A C   1 
ATOM   425  O O   . GLY A 1 71  ? 74.754 -10.983 10.440  1.00 62.74 ?  61  GLY A O   1 
ATOM   426  N N   . HIS A 1 72  ? 74.818 -12.357 12.211  1.00 59.15 ?  62  HIS A N   1 
ATOM   427  C CA  . HIS A 1 72  ? 73.394 -12.167 12.443  1.00 48.57 ?  62  HIS A CA  1 
ATOM   428  C C   . HIS A 1 72  ? 73.112 -10.811 13.079  1.00 57.64 ?  62  HIS A C   1 
ATOM   429  O O   . HIS A 1 72  ? 72.192 -10.099 12.664  1.00 50.91 ?  62  HIS A O   1 
ATOM   430  C CB  . HIS A 1 72  ? 72.842 -13.292 13.310  1.00 54.68 ?  62  HIS A CB  1 
ATOM   431  C CG  . HIS A 1 72  ? 71.374 -13.180 13.545  1.00 61.70 ?  62  HIS A CG  1 
ATOM   432  N ND1 . HIS A 1 72  ? 70.828 -12.222 14.370  1.00 60.88 ?  62  HIS A ND1 1 
ATOM   433  C CD2 . HIS A 1 72  ? 70.331 -13.864 13.015  1.00 61.81 ?  62  HIS A CD2 1 
ATOM   434  C CE1 . HIS A 1 72  ? 69.512 -12.337 14.361  1.00 57.36 ?  62  HIS A CE1 1 
ATOM   435  N NE2 . HIS A 1 72  ? 69.185 -13.325 13.547  1.00 67.51 ?  62  HIS A NE2 1 
ATOM   436  N N   . LEU A 1 73  ? 73.896 -10.437 14.086  1.00 54.24 ?  63  LEU A N   1 
ATOM   437  C CA  . LEU A 1 73  ? 73.662 -9.183  14.786  1.00 51.29 ?  63  LEU A CA  1 
ATOM   438  C C   . LEU A 1 73  ? 74.206 -7.986  14.010  1.00 54.15 ?  63  LEU A C   1 
ATOM   439  O O   . LEU A 1 73  ? 73.743 -6.861  14.222  1.00 53.45 ?  63  LEU A O   1 
ATOM   440  C CB  . LEU A 1 73  ? 74.278 -9.282  16.184  1.00 54.19 ?  63  LEU A CB  1 
ATOM   441  C CG  . LEU A 1 73  ? 73.402 -8.929  17.383  1.00 58.05 ?  63  LEU A CG  1 
ATOM   442  C CD1 . LEU A 1 73  ? 72.063 -9.646  17.291  1.00 46.58 ?  63  LEU A CD1 1 
ATOM   443  C CD2 . LEU A 1 73  ? 74.119 -9.387  18.634  1.00 51.54 ?  63  LEU A CD2 1 
ATOM   444  N N   . GLY A 1 74  ? 75.166 -8.205  13.114  1.00 56.48 ?  64  GLY A N   1 
ATOM   445  C CA  . GLY A 1 74  ? 75.578 -7.161  12.191  1.00 57.83 ?  64  GLY A CA  1 
ATOM   446  C C   . GLY A 1 74  ? 76.188 -5.959  12.886  1.00 59.54 ?  64  GLY A C   1 
ATOM   447  O O   . GLY A 1 74  ? 76.937 -6.079  13.864  1.00 53.56 ?  64  GLY A O   1 
ATOM   448  N N   . GLU A 1 75  ? 75.859 -4.773  12.373  1.00 56.09 ?  65  GLU A N   1 
ATOM   449  C CA  . GLU A 1 75  ? 76.446 -3.528  12.857  1.00 65.59 ?  65  GLU A CA  1 
ATOM   450  C C   . GLU A 1 75  ? 75.769 -2.996  14.113  1.00 64.91 ?  65  GLU A C   1 
ATOM   451  O O   . GLU A 1 75  ? 76.244 -2.004  14.681  1.00 63.37 ?  65  GLU A O   1 
ATOM   452  C CB  . GLU A 1 75  ? 76.392 -2.462  11.756  1.00 61.54 ?  65  GLU A CB  1 
ATOM   453  C CG  . GLU A 1 75  ? 77.040 -2.890  10.445  1.00 67.75 ?  65  GLU A CG  1 
ATOM   454  C CD  . GLU A 1 75  ? 78.544 -3.075  10.567  1.00 75.06 ?  65  GLU A CD  1 
ATOM   455  O OE1 . GLU A 1 75  ? 79.262 -2.052  10.665  1.00 81.87 ?  65  GLU A OE1 1 
ATOM   456  O OE2 . GLU A 1 75  ? 79.007 -4.240  10.566  1.00 69.37 ?  65  GLU A OE2 1 
ATOM   457  N N   . ARG A 1 76  ? 74.683 -3.626  14.562  1.00 57.80 ?  66  ARG A N   1 
ATOM   458  C CA  . ARG A 1 76  ? 73.986 -3.159  15.753  1.00 56.26 ?  66  ARG A CA  1 
ATOM   459  C C   . ARG A 1 76  ? 74.789 -3.364  17.033  1.00 49.31 ?  66  ARG A C   1 
ATOM   460  O O   . ARG A 1 76  ? 74.375 -2.873  18.087  1.00 50.03 ?  66  ARG A O   1 
ATOM   461  C CB  . ARG A 1 76  ? 72.632 -3.863  15.879  1.00 56.42 ?  66  ARG A CB  1 
ATOM   462  C CG  . ARG A 1 76  ? 71.794 -3.879  14.611  1.00 61.66 ?  66  ARG A CG  1 
ATOM   463  C CD  . ARG A 1 76  ? 71.223 -5.260  14.393  1.00 61.20 ?  66  ARG A CD  1 
ATOM   464  N NE  . ARG A 1 76  ? 69.850 -5.344  14.863  1.00 69.18 ?  66  ARG A NE  1 
ATOM   465  C CZ  . ARG A 1 76  ? 69.123 -6.451  14.850  1.00 61.42 ?  66  ARG A CZ  1 
ATOM   466  N NH1 . ARG A 1 76  ? 69.624 -7.603  14.433  1.00 60.55 ?  66  ARG A NH1 1 
ATOM   467  N NH2 . ARG A 1 76  ? 67.863 -6.400  15.272  1.00 59.83 ?  66  ARG A NH2 1 
ATOM   468  N N   . SER A 1 77  ? 75.921 -4.059  16.978  1.00 52.40 ?  67  SER A N   1 
ATOM   469  C CA  . SER A 1 77  ? 76.695 -4.322  18.181  1.00 53.68 ?  67  SER A CA  1 
ATOM   470  C C   . SER A 1 77  ? 78.183 -4.249  17.871  1.00 58.24 ?  67  SER A C   1 
ATOM   471  O O   . SER A 1 77  ? 78.624 -4.597  16.768  1.00 48.36 ?  67  SER A O   1 
ATOM   472  C CB  . SER A 1 77  ? 76.355 -5.706  18.774  1.00 46.88 ?  67  SER A CB  1 
ATOM   473  O OG  . SER A 1 77  ? 77.111 -5.989  19.947  1.00 46.43 ?  67  SER A OG  1 
ATOM   474  N N   . LEU A 1 78  ? 78.957 -3.804  18.859  1.00 43.95 ?  68  LEU A N   1 
ATOM   475  C CA  . LEU A 1 78  ? 80.389 -4.043  18.799  1.00 48.66 ?  68  LEU A CA  1 
ATOM   476  C C   . LEU A 1 78  ? 80.677 -5.456  19.303  1.00 51.09 ?  68  LEU A C   1 
ATOM   477  O O   . LEU A 1 78  ? 79.803 -6.127  19.863  1.00 48.31 ?  68  LEU A O   1 
ATOM   478  C CB  . LEU A 1 78  ? 81.148 -2.979  19.602  1.00 51.91 ?  68  LEU A CB  1 
ATOM   479  C CG  . LEU A 1 78  ? 81.033 -1.560  19.020  1.00 51.19 ?  68  LEU A CG  1 
ATOM   480  C CD1 . LEU A 1 78  ? 81.703 -0.521  19.897  1.00 49.38 ?  68  LEU A CD1 1 
ATOM   481  C CD2 . LEU A 1 78  ? 81.587 -1.503  17.603  1.00 42.50 ?  68  LEU A CD2 1 
ATOM   482  N N   . TYR A 1 79  ? 81.910 -5.921  19.083  1.00 46.77 ?  69  TYR A N   1 
ATOM   483  C CA  . TYR A 1 79  ? 82.298 -7.289  19.410  1.00 47.50 ?  69  TYR A CA  1 
ATOM   484  C C   . TYR A 1 79  ? 83.653 -7.314  20.112  1.00 53.88 ?  69  TYR A C   1 
ATOM   485  O O   . TYR A 1 79  ? 84.561 -6.550  19.767  1.00 55.61 ?  69  TYR A O   1 
ATOM   486  C CB  . TYR A 1 79  ? 82.342 -8.166  18.138  1.00 45.04 ?  69  TYR A CB  1 
ATOM   487  C CG  . TYR A 1 79  ? 81.019 -8.187  17.415  1.00 49.82 ?  69  TYR A CG  1 
ATOM   488  C CD1 . TYR A 1 79  ? 79.961 -8.962  17.880  1.00 43.53 ?  69  TYR A CD1 1 
ATOM   489  C CD2 . TYR A 1 79  ? 80.806 -7.386  16.298  1.00 48.86 ?  69  TYR A CD2 1 
ATOM   490  C CE1 . TYR A 1 79  ? 78.729 -8.956  17.231  1.00 49.60 ?  69  TYR A CE1 1 
ATOM   491  C CE2 . TYR A 1 79  ? 79.589 -7.373  15.645  1.00 53.58 ?  69  TYR A CE2 1 
ATOM   492  C CZ  . TYR A 1 79  ? 78.551 -8.159  16.116  1.00 53.87 ?  69  TYR A CZ  1 
ATOM   493  O OH  . TYR A 1 79  ? 77.338 -8.140  15.474  1.00 50.59 ?  69  TYR A OH  1 
ATOM   494  N N   . SER A 1 80  ? 83.776 -8.202  21.100  1.00 50.54 ?  70  SER A N   1 
ATOM   495  C CA  . SER A 1 80  ? 85.025 -8.462  21.808  1.00 44.77 ?  70  SER A CA  1 
ATOM   496  C C   . SER A 1 80  ? 85.180 -9.963  21.978  1.00 51.14 ?  70  SER A C   1 
ATOM   497  O O   . SER A 1 80  ? 84.214 -10.660 22.306  1.00 52.40 ?  70  SER A O   1 
ATOM   498  C CB  . SER A 1 80  ? 85.067 -7.784  23.186  1.00 49.06 ?  70  SER A CB  1 
ATOM   499  O OG  . SER A 1 80  ? 84.928 -6.381  23.078  1.00 45.03 ?  70  SER A OG  1 
ATOM   500  N N   . PHE A 1 81  ? 86.401 -10.451 21.774  1.00 40.88 ?  71  PHE A N   1 
ATOM   501  C CA  . PHE A 1 81  ? 86.677 -11.876 21.672  1.00 48.71 ?  71  PHE A CA  1 
ATOM   502  C C   . PHE A 1 81  ? 87.179 -12.414 23.009  1.00 53.40 ?  71  PHE A C   1 
ATOM   503  O O   . PHE A 1 81  ? 88.093 -11.841 23.608  1.00 52.46 ?  71  PHE A O   1 
ATOM   504  C CB  . PHE A 1 81  ? 87.709 -12.116 20.567  1.00 51.09 ?  71  PHE A CB  1 
ATOM   505  C CG  . PHE A 1 81  ? 88.234 -13.517 20.513  1.00 56.19 ?  71  PHE A CG  1 
ATOM   506  C CD1 . PHE A 1 81  ? 87.368 -14.588 20.351  1.00 58.25 ?  71  PHE A CD1 1 
ATOM   507  C CD2 . PHE A 1 81  ? 89.594 -13.769 20.620  1.00 60.45 ?  71  PHE A CD2 1 
ATOM   508  C CE1 . PHE A 1 81  ? 87.847 -15.879 20.294  1.00 58.72 ?  71  PHE A CE1 1 
ATOM   509  C CE2 . PHE A 1 81  ? 90.080 -15.063 20.569  1.00 66.34 ?  71  PHE A CE2 1 
ATOM   510  C CZ  . PHE A 1 81  ? 89.204 -16.120 20.404  1.00 65.19 ?  71  PHE A CZ  1 
ATOM   511  N N   . GLN A 1 82  ? 86.579 -13.509 23.477  1.00 55.61 ?  72  GLN A N   1 
ATOM   512  C CA  . GLN A 1 82  ? 87.035 -14.219 24.673  1.00 55.29 ?  72  GLN A CA  1 
ATOM   513  C C   . GLN A 1 82  ? 87.720 -15.501 24.220  1.00 61.41 ?  72  GLN A C   1 
ATOM   514  O O   . GLN A 1 82  ? 87.049 -16.460 23.817  1.00 60.78 ?  72  GLN A O   1 
ATOM   515  C CB  . GLN A 1 82  ? 85.881 -14.524 25.630  1.00 61.09 ?  72  GLN A CB  1 
ATOM   516  C CG  . GLN A 1 82  ? 86.304 -14.696 27.096  1.00 57.40 ?  72  GLN A CG  1 
ATOM   517  C CD  . GLN A 1 82  ? 85.242 -15.372 27.951  1.00 62.22 ?  72  GLN A CD  1 
ATOM   518  O OE1 . GLN A 1 82  ? 84.207 -15.802 27.443  1.00 61.94 ?  72  GLN A OE1 1 
ATOM   519  N NE2 . GLN A 1 82  ? 85.495 -15.466 29.260  1.00 56.24 ?  72  GLN A NE2 1 
ATOM   520  N N   . GLU A 1 83  ? 89.055 -15.518 24.287  1.00 53.30 ?  73  GLU A N   1 
ATOM   521  C CA  . GLU A 1 83  ? 89.805 -16.681 23.820  1.00 61.49 ?  73  GLU A CA  1 
ATOM   522  C C   . GLU A 1 83  ? 89.643 -17.870 24.762  1.00 61.91 ?  73  GLU A C   1 
ATOM   523  O O   . GLU A 1 83  ? 89.520 -19.015 24.309  1.00 63.12 ?  73  GLU A O   1 
ATOM   524  C CB  . GLU A 1 83  ? 91.283 -16.321 23.664  1.00 67.54 ?  73  GLU A CB  1 
ATOM   525  C CG  . GLU A 1 83  ? 92.115 -17.379 22.945  1.00 74.61 ?  73  GLU A CG  1 
ATOM   526  C CD  . GLU A 1 83  ? 93.306 -16.784 22.212  1.00 80.83 ?  73  GLU A CD  1 
ATOM   527  O OE1 . GLU A 1 83  ? 94.179 -16.190 22.882  1.00 81.26 ?  73  GLU A OE1 1 
ATOM   528  O OE2 . GLU A 1 83  ? 93.367 -16.906 20.968  1.00 80.40 ?  73  GLU A OE2 1 
ATOM   529  N N   . GLU A 1 84  ? 89.650 -17.623 26.070  1.00 66.25 ?  74  GLU A N   1 
ATOM   530  C CA  . GLU A 1 84  ? 89.504 -18.666 27.075  1.00 68.56 ?  74  GLU A CA  1 
ATOM   531  C C   . GLU A 1 84  ? 88.264 -18.399 27.919  1.00 63.43 ?  74  GLU A C   1 
ATOM   532  O O   . GLU A 1 84  ? 87.881 -17.244 28.133  1.00 61.97 ?  74  GLU A O   1 
ATOM   533  C CB  . GLU A 1 84  ? 90.735 -18.744 27.995  1.00 65.38 ?  74  GLU A CB  1 
ATOM   534  C CG  . GLU A 1 84  ? 91.747 -19.822 27.613  1.00 79.10 ?  74  GLU A CG  1 
ATOM   535  C CD  . GLU A 1 84  ? 93.162 -19.512 28.094  1.00 87.11 ?  74  GLU A CD  1 
ATOM   536  O OE1 . GLU A 1 84  ? 93.786 -20.412 28.706  1.00 83.82 ?  74  GLU A OE1 1 
ATOM   537  O OE2 . GLU A 1 84  ? 93.645 -18.377 27.870  1.00 83.86 -1 74  GLU A OE2 1 
ATOM   538  N N   . GLN A 1 85  ? 87.647 -19.477 28.411  1.00 63.23 ?  75  GLN A N   1 
ATOM   539  C CA  . GLN A 1 85  ? 86.477 -19.375 29.288  1.00 59.49 ?  75  GLN A CA  1 
ATOM   540  C C   . GLN A 1 85  ? 86.956 -19.352 30.737  1.00 60.65 ?  75  GLN A C   1 
ATOM   541  O O   . GLN A 1 85  ? 87.017 -20.377 31.417  1.00 61.43 ?  75  GLN A O   1 
ATOM   542  C CB  . GLN A 1 85  ? 85.503 -20.519 29.028  1.00 56.02 ?  75  GLN A CB  1 
ATOM   543  N N   . LEU A 1 86  ? 87.290 -18.155 31.224  1.00 51.50 ?  76  LEU A N   1 
ATOM   544  C CA  . LEU A 1 86  ? 87.815 -17.976 32.570  1.00 57.67 ?  76  LEU A CA  1 
ATOM   545  C C   . LEU A 1 86  ? 86.830 -17.243 33.478  1.00 58.40 ?  76  LEU A C   1 
ATOM   546  O O   . LEU A 1 86  ? 87.234 -16.592 34.445  1.00 58.86 ?  76  LEU A O   1 
ATOM   547  C CB  . LEU A 1 86  ? 89.151 -17.236 32.522  1.00 57.20 ?  76  LEU A CB  1 
ATOM   548  C CG  . LEU A 1 86  ? 90.238 -17.915 31.686  1.00 59.98 ?  76  LEU A CG  1 
ATOM   549  C CD1 . LEU A 1 86  ? 91.336 -16.931 31.316  1.00 61.13 ?  76  LEU A CD1 1 
ATOM   550  C CD2 . LEU A 1 86  ? 90.806 -19.103 32.431  1.00 55.38 ?  76  LEU A CD2 1 
ATOM   551  N N   . GLY A 1 87  ? 85.543 -17.328 33.176  1.00 52.34 ?  77  GLY A N   1 
ATOM   552  C CA  . GLY A 1 87  ? 84.505 -16.818 34.047  1.00 50.06 ?  77  GLY A CA  1 
ATOM   553  C C   . GLY A 1 87  ? 83.869 -15.544 33.509  1.00 49.55 ?  77  GLY A C   1 
ATOM   554  O O   . GLY A 1 87  ? 84.329 -14.931 32.544  1.00 46.92 ?  77  GLY A O   1 
ATOM   555  N N   . THR A 1 88  ? 82.781 -15.154 34.180  1.00 52.65 ?  78  THR A N   1 
ATOM   556  C CA  . THR A 1 88  ? 81.985 -14.014 33.732  1.00 46.13 ?  78  THR A CA  1 
ATOM   557  C C   . THR A 1 88  ? 82.746 -12.703 33.900  1.00 44.13 ?  78  THR A C   1 
ATOM   558  O O   . THR A 1 88  ? 82.669 -11.820 33.037  1.00 38.96 ?  78  THR A O   1 
ATOM   559  C CB  . THR A 1 88  ? 80.667 -13.962 34.504  1.00 49.83 ?  78  THR A CB  1 
ATOM   560  O OG1 . THR A 1 88  ? 80.925 -14.176 35.896  1.00 46.29 ?  78  THR A OG1 1 
ATOM   561  C CG2 . THR A 1 88  ? 79.721 -15.060 34.015  1.00 40.78 ?  78  THR A CG2 1 
ATOM   562  N N   . ALA A 1 89  ? 83.460 -12.538 35.017  1.00 46.07 ?  79  ALA A N   1 
ATOM   563  C CA  . ALA A 1 89  ? 84.271 -11.332 35.179  1.00 49.22 ?  79  ALA A CA  1 
ATOM   564  C C   . ALA A 1 89  ? 85.279 -11.205 34.044  1.00 43.17 ?  79  ALA A C   1 
ATOM   565  O O   . ALA A 1 89  ? 85.421 -10.131 33.449  1.00 43.60 ?  79  ALA A O   1 
ATOM   566  C CB  . ALA A 1 89  ? 84.980 -11.333 36.533  1.00 41.23 ?  79  ALA A CB  1 
ATOM   567  N N   . HIS A 1 90  ? 85.950 -12.307 33.700  1.00 44.13 ?  80  HIS A N   1 
ATOM   568  C CA  . HIS A 1 90  ? 86.874 -12.295 32.567  1.00 50.98 ?  80  HIS A CA  1 
ATOM   569  C C   . HIS A 1 90  ? 86.161 -11.906 31.272  1.00 52.87 ?  80  HIS A C   1 
ATOM   570  O O   . HIS A 1 90  ? 86.679 -11.103 30.486  1.00 45.74 ?  80  HIS A O   1 
ATOM   571  C CB  . HIS A 1 90  ? 87.526 -13.670 32.419  1.00 46.28 ?  80  HIS A CB  1 
ATOM   572  C CG  . HIS A 1 90  ? 88.540 -13.746 31.322  1.00 52.73 ?  80  HIS A CG  1 
ATOM   573  N ND1 . HIS A 1 90  ? 88.293 -14.387 30.127  1.00 54.27 ?  80  HIS A ND1 1 
ATOM   574  C CD2 . HIS A 1 90  ? 89.819 -13.305 31.255  1.00 47.52 ?  80  HIS A CD2 1 
ATOM   575  C CE1 . HIS A 1 90  ? 89.367 -14.317 29.360  1.00 52.77 ?  80  HIS A CE1 1 
ATOM   576  N NE2 . HIS A 1 90  ? 90.310 -13.673 30.026  1.00 56.11 ?  80  HIS A NE2 1 
ATOM   577  N N   . ALA A 1 91  ? 84.971 -12.475 31.029  1.00 52.78 ?  81  ALA A N   1 
ATOM   578  C CA  . ALA A 1 91  ? 84.240 -12.186 29.794  1.00 44.27 ?  81  ALA A CA  1 
ATOM   579  C C   . ALA A 1 91  ? 83.862 -10.711 29.701  1.00 43.28 ?  81  ALA A C   1 
ATOM   580  O O   . ALA A 1 91  ? 84.032 -10.082 28.647  1.00 46.30 ?  81  ALA A O   1 
ATOM   581  C CB  . ALA A 1 91  ? 82.996 -13.073 29.704  1.00 47.20 ?  81  ALA A CB  1 
ATOM   582  N N   . VAL A 1 92  ? 83.356 -10.137 30.796  1.00 42.26 ?  82  VAL A N   1 
ATOM   583  C CA  . VAL A 1 92  ? 83.018 -8.713  30.805  1.00 40.65 ?  82  VAL A CA  1 
ATOM   584  C C   . VAL A 1 92  ? 84.249 -7.851  30.540  1.00 49.74 ?  82  VAL A C   1 
ATOM   585  O O   . VAL A 1 92  ? 84.161 -6.805  29.884  1.00 51.89 ?  82  VAL A O   1 
ATOM   586  C CB  . VAL A 1 92  ? 82.337 -8.335  32.132  1.00 45.71 ?  82  VAL A CB  1 
ATOM   587  C CG1 . VAL A 1 92  ? 81.885 -6.883  32.091  1.00 51.62 ?  82  VAL A CG1 1 
ATOM   588  C CG2 . VAL A 1 92  ? 81.110 -9.236  32.366  1.00 40.66 ?  82  VAL A CG2 1 
ATOM   589  N N   . GLN A 1 93  ? 85.410 -8.271  31.044  1.00 47.97 ?  83  GLN A N   1 
ATOM   590  C CA  . GLN A 1 93  ? 86.624 -7.479  30.873  1.00 53.75 ?  83  GLN A CA  1 
ATOM   591  C C   . GLN A 1 93  ? 87.019 -7.353  29.406  1.00 49.68 ?  83  GLN A C   1 
ATOM   592  O O   . GLN A 1 93  ? 87.575 -6.327  29.001  1.00 49.72 ?  83  GLN A O   1 
ATOM   593  C CB  . GLN A 1 93  ? 87.766 -8.103  31.678  1.00 53.23 ?  83  GLN A CB  1 
ATOM   594  C CG  . GLN A 1 93  ? 89.122 -7.438  31.462  1.00 60.66 ?  83  GLN A CG  1 
ATOM   595  C CD  . GLN A 1 93  ? 90.035 -7.586  32.656  1.00 56.21 ?  83  GLN A CD  1 
ATOM   596  O OE1 . GLN A 1 93  ? 90.425 -6.599  33.282  1.00 57.90 ?  83  GLN A OE1 1 
ATOM   597  N NE2 . GLN A 1 93  ? 90.398 -8.826  32.969  1.00 56.63 ?  83  GLN A NE2 1 
ATOM   598  N N   . MET A 1 94  ? 86.730 -8.372  28.590  1.00 48.25 ?  84  MET A N   1 
ATOM   599  C CA  . MET A 1 94  ? 87.115 -8.316  27.183  1.00 50.53 ?  84  MET A CA  1 
ATOM   600  C C   . MET A 1 94  ? 86.479 -7.151  26.449  1.00 49.89 ?  84  MET A C   1 
ATOM   601  O O   . MET A 1 94  ? 86.948 -6.792  25.361  1.00 49.03 ?  84  MET A O   1 
ATOM   602  C CB  . MET A 1 94  ? 86.788 -9.645  26.491  1.00 46.19 ?  84  MET A CB  1 
ATOM   603  C CG  . MET A 1 94  ? 87.323 -10.756 27.332  1.00 56.93 ?  84  MET A CG  1 
ATOM   604  S SD  . MET A 1 94  ? 89.045 -11.003 26.852  1.00 56.76 ?  84  MET A SD  1 
ATOM   605  C CE  . MET A 1 94  ? 89.788 -11.114 28.465  1.00 60.69 ?  84  MET A CE  1 
ATOM   606  N N   . ALA A 1 95  ? 85.450 -6.536  27.027  1.00 42.42 ?  85  ALA A N   1 
ATOM   607  C CA  . ALA A 1 95  ? 84.856 -5.338  26.453  1.00 51.35 ?  85  ALA A CA  1 
ATOM   608  C C   . ALA A 1 95  ? 85.644 -4.064  26.766  1.00 53.90 ?  85  ALA A C   1 
ATOM   609  O O   . ALA A 1 95  ? 85.233 -2.981  26.325  1.00 47.75 ?  85  ALA A O   1 
ATOM   610  C CB  . ALA A 1 95  ? 83.415 -5.193  26.947  1.00 43.54 ?  85  ALA A CB  1 
ATOM   611  N N   . LYS A 1 96  ? 86.759 -4.166  27.507  1.00 56.13 ?  86  LYS A N   1 
ATOM   612  C CA  . LYS A 1 96  ? 87.490 -2.970  27.932  1.00 59.01 ?  86  LYS A CA  1 
ATOM   613  C C   . LYS A 1 96  ? 88.013 -2.175  26.740  1.00 56.54 ?  86  LYS A C   1 
ATOM   614  O O   . LYS A 1 96  ? 88.069 -0.942  26.797  1.00 56.67 ?  86  LYS A O   1 
ATOM   615  C CB  . LYS A 1 96  ? 88.640 -3.352  28.876  1.00 55.26 ?  86  LYS A CB  1 
ATOM   616  C CG  . LYS A 1 96  ? 89.885 -3.911  28.192  1.00 60.07 ?  86  LYS A CG  1 
ATOM   617  C CD  . LYS A 1 96  ? 90.456 -5.105  28.941  1.00 64.02 ?  86  LYS A CD  1 
ATOM   618  C CE  . LYS A 1 96  ? 91.828 -5.514  28.411  1.00 68.54 ?  86  LYS A CE  1 
ATOM   619  N NZ  . LYS A 1 96  ? 92.714 -4.341  28.146  1.00 73.66 ?  86  LYS A NZ  1 
ATOM   620  N N   . SER A 1 97  ? 88.368 -2.860  25.650  1.00 53.69 ?  87  SER A N   1 
ATOM   621  C CA  . SER A 1 97  ? 88.826 -2.183  24.439  1.00 59.27 ?  87  SER A CA  1 
ATOM   622  C C   . SER A 1 97  ? 87.858 -1.088  24.009  1.00 61.95 ?  87  SER A C   1 
ATOM   623  O O   . SER A 1 97  ? 88.277 -0.002  23.590  1.00 59.44 ?  87  SER A O   1 
ATOM   624  C CB  . SER A 1 97  ? 88.989 -3.208  23.320  1.00 61.12 ?  87  SER A CB  1 
ATOM   625  O OG  . SER A 1 97  ? 90.005 -4.141  23.649  1.00 84.65 ?  87  SER A OG  1 
ATOM   626  N N   . HIS A 1 98  ? 86.554 -1.351  24.128  1.00 59.00 ?  88  HIS A N   1 
ATOM   627  C CA  . HIS A 1 98  ? 85.527 -0.418  23.687  1.00 49.19 ?  88  HIS A CA  1 
ATOM   628  C C   . HIS A 1 98  ? 85.010 0.494   24.784  1.00 44.64 ?  88  HIS A C   1 
ATOM   629  O O   . HIS A 1 98  ? 84.534 1.593   24.477  1.00 52.10 ?  88  HIS A O   1 
ATOM   630  C CB  . HIS A 1 98  ? 84.328 -1.176  23.104  1.00 51.50 ?  88  HIS A CB  1 
ATOM   631  C CG  . HIS A 1 98  ? 84.672 -2.101  21.978  1.00 55.40 ?  88  HIS A CG  1 
ATOM   632  N ND1 . HIS A 1 98  ? 84.935 -1.654  20.700  1.00 53.44 ?  88  HIS A ND1 1 
ATOM   633  C CD2 . HIS A 1 98  ? 84.770 -3.453  21.932  1.00 55.53 ?  88  HIS A CD2 1 
ATOM   634  C CE1 . HIS A 1 98  ? 85.195 -2.690  19.919  1.00 57.18 ?  88  HIS A CE1 1 
ATOM   635  N NE2 . HIS A 1 98  ? 85.097 -3.793  20.642  1.00 55.02 ?  88  HIS A NE2 1 
ATOM   636  N N   . LEU A 1 99  ? 85.040 0.067   26.051  1.00 47.00 ?  89  LEU A N   1 
ATOM   637  C CA  . LEU A 1 99  ? 84.301 0.778   27.088  1.00 53.18 ?  89  LEU A CA  1 
ATOM   638  C C   . LEU A 1 99  ? 85.126 1.277   28.264  1.00 54.56 ?  89  LEU A C   1 
ATOM   639  O O   . LEU A 1 99  ? 84.604 2.081   29.047  1.00 48.17 ?  89  LEU A O   1 
ATOM   640  C CB  . LEU A 1 99  ? 83.163 -0.098  27.644  1.00 52.73 ?  89  LEU A CB  1 
ATOM   641  C CG  . LEU A 1 99  ? 82.112 -0.621  26.657  1.00 50.90 ?  89  LEU A CG  1 
ATOM   642  C CD1 . LEU A 1 99  ? 81.210 -1.650  27.329  1.00 39.22 ?  89  LEU A CD1 1 
ATOM   643  C CD2 . LEU A 1 99  ? 81.288 0.544   26.096  1.00 45.16 ?  89  LEU A CD2 1 
ATOM   644  N N   . GLU A 1 100 ? 86.383 0.844   28.409  1.00 55.37 ?  90  GLU A N   1 
ATOM   645  C CA  . GLU A 1 100 ? 87.118 1.087   29.651  1.00 62.44 ?  90  GLU A CA  1 
ATOM   646  C C   . GLU A 1 100 ? 87.182 2.569   30.017  1.00 63.70 ?  90  GLU A C   1 
ATOM   647  O O   . GLU A 1 100 ? 87.143 2.912   31.205  1.00 61.90 ?  90  GLU A O   1 
ATOM   648  C CB  . GLU A 1 100 ? 88.524 0.488   29.556  1.00 65.27 ?  90  GLU A CB  1 
ATOM   649  C CG  . GLU A 1 100 ? 89.520 1.286   28.719  1.00 73.01 ?  90  GLU A CG  1 
ATOM   650  C CD  . GLU A 1 100 ? 90.901 0.644   28.696  1.00 76.92 ?  90  GLU A CD  1 
ATOM   651  O OE1 . GLU A 1 100 ? 91.538 0.560   29.767  1.00 81.04 ?  90  GLU A OE1 1 
ATOM   652  O OE2 . GLU A 1 100 ? 91.346 0.223   27.606  1.00 77.18 -1 90  GLU A OE2 1 
ATOM   653  N N   . ASP A 1 101 ? 87.239 3.464   29.032  1.00 53.51 ?  91  ASP A N   1 
ATOM   654  C CA  . ASP A 1 101 ? 87.361 4.887   29.322  1.00 63.38 ?  91  ASP A CA  1 
ATOM   655  C C   . ASP A 1 101 ? 86.037 5.634   29.193  1.00 70.26 ?  91  ASP A C   1 
ATOM   656  O O   . ASP A 1 101 ? 86.040 6.869   29.137  1.00 69.91 ?  91  ASP A O   1 
ATOM   657  C CB  . ASP A 1 101 ? 88.420 5.528   28.419  1.00 71.71 ?  91  ASP A CB  1 
ATOM   658  C CG  . ASP A 1 101 ? 89.787 4.859   28.544  1.00 80.60 ?  91  ASP A CG  1 
ATOM   659  O OD1 . ASP A 1 101 ? 90.266 4.683   29.687  1.00 79.55 ?  91  ASP A OD1 1 
ATOM   660  O OD2 . ASP A 1 101 ? 90.392 4.527   27.499  1.00 80.91 ?  91  ASP A OD2 1 
ATOM   661  N N   . LYS A 1 102 ? 84.910 4.924   29.153  1.00 56.42 ?  92  LYS A N   1 
ATOM   662  C CA  . LYS A 1 102 ? 83.608 5.565   29.032  1.00 54.28 ?  92  LYS A CA  1 
ATOM   663  C C   . LYS A 1 102 ? 83.052 5.931   30.411  1.00 52.00 ?  92  LYS A C   1 
ATOM   664  O O   . LYS A 1 102 ? 83.480 5.403   31.438  1.00 55.14 ?  92  LYS A O   1 
ATOM   665  C CB  . LYS A 1 102 ? 82.627 4.655   28.287  1.00 54.88 ?  92  LYS A CB  1 
ATOM   666  N N   . GLU A 1 103 ? 82.088 6.851   30.425  1.00 54.35 ?  93  GLU A N   1 
ATOM   667  C CA  . GLU A 1 103 ? 81.421 7.265   31.653  1.00 57.15 ?  93  GLU A CA  1 
ATOM   668  C C   . GLU A 1 103 ? 79.926 7.006   31.545  1.00 56.83 ?  93  GLU A C   1 
ATOM   669  O O   . GLU A 1 103 ? 79.344 7.140   30.465  1.00 59.80 ?  93  GLU A O   1 
ATOM   670  C CB  . GLU A 1 103 ? 81.673 8.748   31.948  1.00 66.65 ?  93  GLU A CB  1 
ATOM   671  C CG  . GLU A 1 103 ? 83.013 8.985   32.611  1.00 65.91 ?  93  GLU A CG  1 
ATOM   672  C CD  . GLU A 1 103 ? 82.919 9.007   34.120  1.00 65.11 ?  93  GLU A CD  1 
ATOM   673  O OE1 . GLU A 1 103 ? 81.806 8.848   34.673  1.00 67.64 ?  93  GLU A OE1 1 
ATOM   674  O OE2 . GLU A 1 103 ? 83.978 9.139   34.758  1.00 63.54 ?  93  GLU A OE2 1 
ATOM   675  N N   . GLY A 1 104 ? 79.305 6.638   32.669  1.00 48.83 ?  94  GLY A N   1 
ATOM   676  C CA  . GLY A 1 104 ? 77.874 6.386   32.699  1.00 57.65 ?  94  GLY A CA  1 
ATOM   677  C C   . GLY A 1 104 ? 77.500 4.996   33.189  1.00 57.92 ?  94  GLY A C   1 
ATOM   678  O O   . GLY A 1 104 ? 78.306 4.333   33.849  1.00 54.64 ?  94  GLY A O   1 
ATOM   679  N N   . THR A 1 105 ? 76.291 4.539   32.858  1.00 48.78 ?  95  THR A N   1 
ATOM   680  C CA  . THR A 1 105 ? 75.802 3.242   33.309  1.00 42.51 ?  95  THR A CA  1 
ATOM   681  C C   . THR A 1 105 ? 76.101 2.151   32.286  1.00 47.69 ?  95  THR A C   1 
ATOM   682  O O   . THR A 1 105 ? 76.016 2.368   31.074  1.00 44.65 ?  95  THR A O   1 
ATOM   683  C CB  . THR A 1 105 ? 74.298 3.303   33.561  1.00 49.14 ?  95  THR A CB  1 
ATOM   684  O OG1 . THR A 1 105 ? 74.023 4.357   34.491  1.00 48.83 ?  95  THR A OG1 1 
ATOM   685  C CG2 . THR A 1 105 ? 73.793 1.963   34.132  1.00 45.86 ?  95  THR A CG2 1 
ATOM   686  N N   . THR A 1 106 ? 76.440 0.968   32.785  1.00 46.13 ?  96  THR A N   1 
ATOM   687  C CA  . THR A 1 106 ? 76.667 -0.203  31.950  1.00 38.21 ?  96  THR A CA  1 
ATOM   688  C C   . THR A 1 106 ? 75.932 -1.375  32.573  1.00 43.96 ?  96  THR A C   1 
ATOM   689  O O   . THR A 1 106 ? 76.118 -1.664  33.760  1.00 46.13 ?  96  THR A O   1 
ATOM   690  C CB  . THR A 1 106 ? 78.162 -0.494  31.821  1.00 45.16 ?  96  THR A CB  1 
ATOM   691  O OG1 . THR A 1 106 ? 78.764 0.540   31.033  1.00 39.25 ?  96  THR A OG1 1 
ATOM   692  C CG2 . THR A 1 106 ? 78.407 -1.867  31.171  1.00 45.58 ?  96  THR A CG2 1 
ATOM   693  N N   . ILE A 1 107 ? 75.075 -2.019  31.798  1.00 39.54 ?  97  ILE A N   1 
ATOM   694  C CA  . ILE A 1 107 ? 74.379 -3.207  32.271  1.00 40.78 ?  97  ILE A CA  1 
ATOM   695  C C   . ILE A 1 107 ? 75.013 -4.427  31.625  1.00 44.92 ?  97  ILE A C   1 
ATOM   696  O O   . ILE A 1 107 ? 75.499 -4.378  30.484  1.00 39.42 ?  97  ILE A O   1 
ATOM   697  C CB  . ILE A 1 107 ? 72.862 -3.150  31.998  1.00 38.36 ?  97  ILE A CB  1 
ATOM   698  C CG1 . ILE A 1 107 ? 72.583 -3.035  30.498  1.00 38.54 ?  97  ILE A CG1 1 
ATOM   699  C CG2 . ILE A 1 107 ? 72.233 -2.018  32.760  1.00 37.45 ?  97  ILE A CG2 1 
ATOM   700  C CD1 . ILE A 1 107 ? 71.099 -3.239  30.139  1.00 40.27 ?  97  ILE A CD1 1 
ATOM   701  N N   . VAL A 1 108 ? 75.039 -5.522  32.383  1.00 39.49 ?  98  VAL A N   1 
ATOM   702  C CA  . VAL A 1 108 ? 75.587 -6.795  31.940  1.00 37.88 ?  98  VAL A CA  1 
ATOM   703  C C   . VAL A 1 108 ? 74.438 -7.797  31.912  1.00 39.86 ?  98  VAL A C   1 
ATOM   704  O O   . VAL A 1 108 ? 73.780 -8.034  32.936  1.00 36.76 ?  98  VAL A O   1 
ATOM   705  C CB  . VAL A 1 108 ? 76.728 -7.272  32.851  1.00 39.65 ?  98  VAL A CB  1 
ATOM   706  C CG1 . VAL A 1 108 ? 77.166 -8.672  32.463  1.00 37.95 ?  98  VAL A CG1 1 
ATOM   707  C CG2 . VAL A 1 108 ? 77.922 -6.276  32.816  1.00 35.46 ?  98  VAL A CG2 1 
ATOM   708  N N   . VAL A 1 109 ? 74.170 -8.352  30.734  1.00 38.73 ?  99  VAL A N   1 
ATOM   709  C CA  . VAL A 1 109 ? 73.120 -9.347  30.546  1.00 35.79 ?  99  VAL A CA  1 
ATOM   710  C C   . VAL A 1 109 ? 73.679 -10.495 29.714  1.00 42.60 ?  99  VAL A C   1 
ATOM   711  O O   . VAL A 1 109 ? 74.640 -10.338 28.958  1.00 45.69 ?  99  VAL A O   1 
ATOM   712  C CB  . VAL A 1 109 ? 71.856 -8.749  29.887  1.00 40.70 ?  99  VAL A CB  1 
ATOM   713  C CG1 . VAL A 1 109 ? 71.421 -7.480  30.593  1.00 42.37 ?  99  VAL A CG1 1 
ATOM   714  C CG2 . VAL A 1 109 ? 72.176 -8.384  28.448  1.00 43.97 ?  99  VAL A CG2 1 
ATOM   715  N N   A CYS A 1 110 ? 73.065 -11.663 29.870  0.59 38.21 ?  100 CYS A N   1 
ATOM   716  N N   B CYS A 1 110 ? 73.084 -11.670 29.868  0.41 38.24 ?  100 CYS A N   1 
ATOM   717  C CA  A CYS A 1 110 ? 73.447 -12.848 29.118  0.59 38.02 ?  100 CYS A CA  1 
ATOM   718  C CA  B CYS A 1 110 ? 73.535 -12.805 29.080  0.41 38.05 ?  100 CYS A CA  1 
ATOM   719  C C   A CYS A 1 110 ? 72.559 -12.969 27.887  0.59 38.50 ?  100 CYS A C   1 
ATOM   720  C C   B CYS A 1 110 ? 72.580 -13.015 27.913  0.41 38.51 ?  100 CYS A C   1 
ATOM   721  O O   A CYS A 1 110 ? 71.383 -12.604 27.923  0.59 41.10 ?  100 CYS A O   1 
ATOM   722  O O   B CYS A 1 110 ? 71.380 -12.758 28.016  0.41 41.00 ?  100 CYS A O   1 
ATOM   723  C CB  A CYS A 1 110 ? 73.340 -14.109 29.982  0.59 40.67 ?  100 CYS A CB  1 
ATOM   724  C CB  B CYS A 1 110 ? 73.637 -14.079 29.925  0.41 40.73 ?  100 CYS A CB  1 
ATOM   725  S SG  A CYS A 1 110 ? 74.564 -14.232 31.321  0.59 43.84 ?  100 CYS A SG  1 
ATOM   726  S SG  B CYS A 1 110 ? 74.315 -15.506 29.019  0.41 43.19 ?  100 CYS A SG  1 
ATOM   727  N N   . GLY A 1 111 ? 73.132 -13.458 26.790  1.00 40.93 ?  101 GLY A N   1 
ATOM   728  C CA  . GLY A 1 111 ? 72.349 -13.638 25.589  1.00 36.92 ?  101 GLY A CA  1 
ATOM   729  C C   . GLY A 1 111 ? 71.410 -14.828 25.605  1.00 34.91 ?  101 GLY A C   1 
ATOM   730  O O   . GLY A 1 111 ? 70.726 -15.070 24.605  1.00 41.33 ?  101 GLY A O   1 
ATOM   731  N N   . ASP A 1 112 ? 71.366 -15.592 26.703  1.00 38.08 ?  102 ASP A N   1 
ATOM   732  C CA  . ASP A 1 112 ? 70.498 -16.760 26.799  1.00 41.04 ?  102 ASP A CA  1 
ATOM   733  C C   . ASP A 1 112 ? 69.281 -16.506 27.687  1.00 35.27 ?  102 ASP A C   1 
ATOM   734  O O   . ASP A 1 112 ? 68.673 -17.456 28.201  1.00 37.86 ?  102 ASP A O   1 
ATOM   735  C CB  . ASP A 1 112 ? 71.297 -17.969 27.294  1.00 40.25 ?  102 ASP A CB  1 
ATOM   736  C CG  . ASP A 1 112 ? 71.824 -17.793 28.723  1.00 43.49 ?  102 ASP A CG  1 
ATOM   737  O OD1 . ASP A 1 112 ? 71.595 -16.726 29.335  1.00 42.64 ?  102 ASP A OD1 1 
ATOM   738  O OD2 . ASP A 1 112 ? 72.499 -18.721 29.221  1.00 48.97 -1 102 ASP A OD2 1 
ATOM   739  N N   . THR A 1 113 ? 68.896 -15.240 27.866  1.00 38.33 ?  103 THR A N   1 
ATOM   740  C CA  . THR A 1 113 ? 67.738 -14.876 28.679  1.00 38.47 ?  103 THR A CA  1 
ATOM   741  C C   . THR A 1 113 ? 66.751 -14.130 27.786  1.00 36.80 ?  103 THR A C   1 
ATOM   742  O O   . THR A 1 113 ? 66.589 -12.905 27.898  1.00 34.49 ?  103 THR A O   1 
ATOM   743  C CB  . THR A 1 113 ? 68.135 -14.035 29.893  1.00 41.14 ?  103 THR A CB  1 
ATOM   744  O OG1 . THR A 1 113 ? 68.753 -12.828 29.445  1.00 48.10 ?  103 THR A OG1 1 
ATOM   745  C CG2 . THR A 1 113 ? 69.136 -14.802 30.756  1.00 38.33 ?  103 THR A CG2 1 
ATOM   746  N N   . PRO A 1 114 ? 66.065 -14.849 26.886  1.00 42.35 ?  104 PRO A N   1 
ATOM   747  C CA  . PRO A 1 114 ? 65.279 -14.174 25.836  1.00 37.94 ?  104 PRO A CA  1 
ATOM   748  C C   . PRO A 1 114 ? 64.001 -13.519 26.324  1.00 36.69 ?  104 PRO A C   1 
ATOM   749  O O   . PRO A 1 114 ? 63.413 -12.739 25.569  1.00 39.92 ?  104 PRO A O   1 
ATOM   750  C CB  . PRO A 1 114 ? 64.976 -15.310 24.856  1.00 38.65 ?  104 PRO A CB  1 
ATOM   751  C CG  . PRO A 1 114 ? 64.910 -16.541 25.762  1.00 38.28 ?  104 PRO A CG  1 
ATOM   752  C CD  . PRO A 1 114 ? 66.012 -16.321 26.758  1.00 36.45 ?  104 PRO A CD  1 
ATOM   753  N N   . LEU A 1 115 ? 63.534 -13.804 27.535  1.00 34.64 ?  105 LEU A N   1 
ATOM   754  C CA  . LEU A 1 115 ? 62.291 -13.199 27.984  1.00 38.60 ?  105 LEU A CA  1 
ATOM   755  C C   . LEU A 1 115 ? 62.505 -11.882 28.714  1.00 40.79 ?  105 LEU A C   1 
ATOM   756  O O   . LEU A 1 115 ? 61.523 -11.288 29.171  1.00 38.88 ?  105 LEU A O   1 
ATOM   757  C CB  . LEU A 1 115 ? 61.520 -14.154 28.890  1.00 36.69 ?  105 LEU A CB  1 
ATOM   758  C CG  . LEU A 1 115 ? 61.365 -15.588 28.393  1.00 41.12 ?  105 LEU A CG  1 
ATOM   759  C CD1 . LEU A 1 115 ? 60.597 -16.361 29.431  1.00 44.87 ?  105 LEU A CD1 1 
ATOM   760  C CD2 . LEU A 1 115 ? 60.702 -15.685 27.034  1.00 38.37 ?  105 LEU A CD2 1 
ATOM   761  N N   . ILE A 1 116 ? 63.752 -11.411 28.838  1.00 40.59 ?  106 ILE A N   1 
ATOM   762  C CA  . ILE A 1 116 ? 63.996 -10.162 29.556  1.00 42.15 ?  106 ILE A CA  1 
ATOM   763  C C   . ILE A 1 116 ? 63.276 -9.009  28.866  1.00 42.04 ?  106 ILE A C   1 
ATOM   764  O O   . ILE A 1 116 ? 63.360 -8.840  27.643  1.00 41.69 ?  106 ILE A O   1 
ATOM   765  C CB  . ILE A 1 116 ? 65.507 -9.903  29.706  1.00 42.79 ?  106 ILE A CB  1 
ATOM   766  C CG1 . ILE A 1 116 ? 65.706 -8.693  30.618  1.00 36.82 ?  106 ILE A CG1 1 
ATOM   767  C CG2 . ILE A 1 116 ? 66.212 -9.722  28.322  1.00 29.58 ?  106 ILE A CG2 1 
ATOM   768  C CD1 . ILE A 1 116 ? 65.747 -9.051  32.090  1.00 38.33 ?  106 ILE A CD1 1 
ATOM   769  N N   . THR A 1 117 ? 62.545 -8.212  29.647  1.00 40.58 ?  107 THR A N   1 
ATOM   770  C CA  . THR A 1 117 ? 61.771 -7.123  29.067  1.00 42.91 ?  107 THR A CA  1 
ATOM   771  C C   . THR A 1 117 ? 62.525 -5.800  29.144  1.00 43.64 ?  107 THR A C   1 
ATOM   772  O O   . THR A 1 117 ? 63.301 -5.548  30.072  1.00 36.85 ?  107 THR A O   1 
ATOM   773  C CB  . THR A 1 117 ? 60.425 -6.942  29.765  1.00 43.88 ?  107 THR A CB  1 
ATOM   774  O OG1 . THR A 1 117 ? 60.637 -6.497  31.110  1.00 38.78 ?  107 THR A OG1 1 
ATOM   775  C CG2 . THR A 1 117 ? 59.673 -8.263  29.786  1.00 52.46 ?  107 THR A CG2 1 
ATOM   776  N N   . LYS A 1 118 ? 62.262 -4.938  28.165  1.00 42.33 ?  108 LYS A N   1 
ATOM   777  C CA  . LYS A 1 118 ? 62.814 -3.592  28.222  1.00 42.13 ?  108 LYS A CA  1 
ATOM   778  C C   . LYS A 1 118 ? 62.281 -2.818  29.425  1.00 42.51 ?  108 LYS A C   1 
ATOM   779  O O   . LYS A 1 118 ? 63.016 -2.016  30.009  1.00 40.71 ?  108 LYS A O   1 
ATOM   780  C CB  . LYS A 1 118 ? 62.532 -2.862  26.908  1.00 44.97 ?  108 LYS A CB  1 
ATOM   781  C CG  . LYS A 1 118 ? 61.070 -2.514  26.701  1.00 47.95 ?  108 LYS A CG  1 
ATOM   782  C CD  . LYS A 1 118 ? 60.849 -1.723  25.415  1.00 49.50 ?  108 LYS A CD  1 
ATOM   783  C CE  . LYS A 1 118 ? 59.516 -2.111  24.787  1.00 57.43 ?  108 LYS A CE  1 
ATOM   784  N NZ  . LYS A 1 118 ? 58.910 -1.024  23.975  1.00 49.81 ?  108 LYS A NZ  1 
ATOM   785  N N   A GLU A 1 119 ? 61.032 -3.063  29.846  0.89 36.54 ?  109 GLU A N   1 
ATOM   786  C CA  A GLU A 1 119 ? 60.516 -2.358  31.024  0.89 41.17 ?  109 GLU A CA  1 
ATOM   787  C C   A GLU A 1 119 ? 61.391 -2.605  32.250  0.89 38.04 ?  109 GLU A C   1 
ATOM   788  O O   A GLU A 1 119 ? 61.683 -1.678  33.015  0.89 37.90 ?  109 GLU A O   1 
ATOM   789  C CB  . GLU A 1 119 ? 59.074 -2.775  31.331  1.00 41.91 ?  109 GLU A CB  1 
ATOM   790  C CG  . GLU A 1 119 ? 57.994 -2.284  30.355  1.00 48.96 ?  109 GLU A CG  1 
ATOM   791  C CD  . GLU A 1 119 ? 58.135 -2.884  28.962  1.00 52.17 ?  109 GLU A CD  1 
ATOM   792  O OE1 . GLU A 1 119 ? 58.468 -4.086  28.859  1.00 49.36 ?  109 GLU A OE1 1 
ATOM   793  O OE2 . GLU A 1 119 ? 57.889 -2.162  27.973  1.00 62.66 -1 109 GLU A OE2 1 
ATOM   794  N N   . THR A 1 120 ? 61.814 -3.852  32.457  1.00 39.61 ?  110 THR A N   1 
ATOM   795  C CA  . THR A 1 120 ? 62.585 -4.175  33.652  1.00 41.54 ?  110 THR A CA  1 
ATOM   796  C C   . THR A 1 120 ? 63.994 -3.595  33.576  1.00 39.57 ?  110 THR A C   1 
ATOM   797  O O   . THR A 1 120 ? 64.528 -3.112  34.584  1.00 38.39 ?  110 THR A O   1 
ATOM   798  C CB  . THR A 1 120 ? 62.606 -5.691  33.852  1.00 40.01 ?  110 THR A CB  1 
ATOM   799  O OG1 . THR A 1 120 ? 61.308 -6.133  34.295  1.00 40.51 ?  110 THR A OG1 1 
ATOM   800  C CG2 . THR A 1 120 ? 63.676 -6.099  34.864  1.00 40.21 ?  110 THR A CG2 1 
ATOM   801  N N   . LEU A 1 121 ? 64.602 -3.625  32.386  1.00 32.96 ?  111 LEU A N   1 
ATOM   802  C CA  . LEU A 1 121 ? 65.918 -3.019  32.182  1.00 34.16 ?  111 LEU A CA  1 
ATOM   803  C C   . LEU A 1 121 ? 65.872 -1.503  32.357  1.00 41.14 ?  111 LEU A C   1 
ATOM   804  O O   . LEU A 1 121 ? 66.827 -0.899  32.860  1.00 41.93 ?  111 LEU A O   1 
ATOM   805  C CB  . LEU A 1 121 ? 66.423 -3.367  30.784  1.00 34.66 ?  111 LEU A CB  1 
ATOM   806  C CG  . LEU A 1 121 ? 66.722 -4.852  30.577  1.00 38.41 ?  111 LEU A CG  1 
ATOM   807  C CD1 . LEU A 1 121 ? 67.388 -5.076  29.218  1.00 33.87 ?  111 LEU A CD1 1 
ATOM   808  C CD2 . LEU A 1 121 ? 67.572 -5.390  31.734  1.00 33.84 ?  111 LEU A CD2 1 
ATOM   809  N N   . VAL A 1 122 ? 64.783 -0.867  31.914  1.00 43.87 ?  112 VAL A N   1 
ATOM   810  C CA  . VAL A 1 122 ? 64.604 0.569   32.136  1.00 39.10 ?  112 VAL A CA  1 
ATOM   811  C C   . VAL A 1 122 ? 64.596 0.878   33.625  1.00 44.32 ?  112 VAL A C   1 
ATOM   812  O O   . VAL A 1 122 ? 65.360 1.725   34.106  1.00 45.88 ?  112 VAL A O   1 
ATOM   813  C CB  . VAL A 1 122 ? 63.309 1.060   31.464  1.00 37.78 ?  112 VAL A CB  1 
ATOM   814  C CG1 . VAL A 1 122 ? 62.921 2.463   31.994  1.00 40.46 ?  112 VAL A CG1 1 
ATOM   815  C CG2 . VAL A 1 122 ? 63.473 1.081   29.957  1.00 38.31 ?  112 VAL A CG2 1 
ATOM   816  N N   . THR A 1 123 ? 63.724 0.194   34.375  1.00 36.96 ?  113 THR A N   1 
ATOM   817  C CA  . THR A 1 123 ? 63.604 0.448   35.805  1.00 35.69 ?  113 THR A CA  1 
ATOM   818  C C   . THR A 1 123 ? 64.900 0.095   36.541  1.00 42.27 ?  113 THR A C   1 
ATOM   819  O O   . THR A 1 123 ? 65.308 0.809   37.466  1.00 39.29 ?  113 THR A O   1 
ATOM   820  C CB  . THR A 1 123 ? 62.408 -0.329  36.369  1.00 43.20 ?  113 THR A CB  1 
ATOM   821  O OG1 . THR A 1 123 ? 61.212 0.056   35.668  1.00 42.77 ?  113 THR A OG1 1 
ATOM   822  C CG2 . THR A 1 123 ? 62.212 -0.012  37.842  1.00 45.07 ?  113 THR A CG2 1 
ATOM   823  N N   . LEU A 1 124 ? 65.555 -1.007  36.149  1.00 40.24 ?  114 LEU A N   1 
ATOM   824  C CA  . LEU A 1 124 ? 66.880 -1.332  36.676  1.00 38.32 ?  114 LEU A CA  1 
ATOM   825  C C   . LEU A 1 124 ? 67.833 -0.149  36.540  1.00 43.99 ?  114 LEU A C   1 
ATOM   826  O O   . LEU A 1 124 ? 68.536 0.221   37.493  1.00 40.39 ?  114 LEU A O   1 
ATOM   827  C CB  . LEU A 1 124 ? 67.447 -2.555  35.947  1.00 35.36 ?  114 LEU A CB  1 
ATOM   828  C CG  . LEU A 1 124 ? 68.889 -2.978  36.319  1.00 35.92 ?  114 LEU A CG  1 
ATOM   829  C CD1 . LEU A 1 124 ? 69.030 -3.413  37.795  1.00 38.66 ?  114 LEU A CD1 1 
ATOM   830  C CD2 . LEU A 1 124 ? 69.489 -4.014  35.361  1.00 35.25 ?  114 LEU A CD2 1 
ATOM   831  N N   . ILE A 1 125 ? 67.887 0.446   35.346  1.00 38.02 ?  115 ILE A N   1 
ATOM   832  C CA  . ILE A 1 125 ? 68.784 1.580   35.125  1.00 38.27 ?  115 ILE A CA  1 
ATOM   833  C C   . ILE A 1 125 ? 68.340 2.795   35.930  1.00 43.69 ?  115 ILE A C   1 
ATOM   834  O O   . ILE A 1 125 ? 69.174 3.510   36.506  1.00 41.12 ?  115 ILE A O   1 
ATOM   835  C CB  . ILE A 1 125 ? 68.893 1.906   33.623  1.00 42.97 ?  115 ILE A CB  1 
ATOM   836  C CG1 . ILE A 1 125 ? 69.595 0.773   32.870  1.00 43.02 ?  115 ILE A CG1 1 
ATOM   837  C CG2 . ILE A 1 125 ? 69.573 3.278   33.399  1.00 45.46 ?  115 ILE A CG2 1 
ATOM   838  C CD1 . ILE A 1 125 ? 69.335 0.783   31.359  1.00 41.64 ?  115 ILE A CD1 1 
ATOM   839  N N   . ALA A 1 126 ? 67.032 3.057   35.981  1.00 42.11 ?  116 ALA A N   1 
ATOM   840  C CA  . ALA A 1 126 ? 66.549 4.223   36.715  1.00 50.99 ?  116 ALA A CA  1 
ATOM   841  C C   . ALA A 1 126 ? 66.817 4.081   38.207  1.00 48.60 ?  116 ALA A C   1 
ATOM   842  O O   . ALA A 1 126 ? 67.252 5.036   38.861  1.00 47.76 ?  116 ALA A O   1 
ATOM   843  C CB  . ALA A 1 126 ? 65.058 4.436   36.457  1.00 43.89 ?  116 ALA A CB  1 
ATOM   844  N N   . HIS A 1 127 ? 66.558 2.896   38.760  1.00 41.33 ?  117 HIS A N   1 
ATOM   845  C CA  . HIS A 1 127 ? 66.852 2.644   40.166  1.00 46.16 ?  117 HIS A CA  1 
ATOM   846  C C   . HIS A 1 127 ? 68.333 2.866   40.461  1.00 43.93 ?  117 HIS A C   1 
ATOM   847  O O   . HIS A 1 127 ? 68.689 3.566   41.415  1.00 43.18 ?  117 HIS A O   1 
ATOM   848  C CB  . HIS A 1 127 ? 66.404 1.225   40.516  1.00 49.78 ?  117 HIS A CB  1 
ATOM   849  C CG  . HIS A 1 127 ? 66.623 0.843   41.945  1.00 53.30 ?  117 HIS A CG  1 
ATOM   850  N ND1 . HIS A 1 127 ? 65.589 0.751   42.854  1.00 54.13 ?  117 HIS A ND1 1 
ATOM   851  C CD2 . HIS A 1 127 ? 67.742 0.464   42.608  1.00 54.41 ?  117 HIS A CD2 1 
ATOM   852  C CE1 . HIS A 1 127 ? 66.069 0.372   44.026  1.00 50.72 ?  117 HIS A CE1 1 
ATOM   853  N NE2 . HIS A 1 127 ? 67.370 0.184   43.903  1.00 52.34 ?  117 HIS A NE2 1 
ATOM   854  N N   . HIS A 1 128 ? 69.206 2.296   39.626  1.00 41.35 ?  118 HIS A N   1 
ATOM   855  C CA  . HIS A 1 128 ? 70.649 2.490   39.747  1.00 43.79 ?  118 HIS A CA  1 
ATOM   856  C C   . HIS A 1 128 ? 71.022 3.971   39.737  1.00 49.47 ?  118 HIS A C   1 
ATOM   857  O O   . HIS A 1 128 ? 71.751 4.447   40.614  1.00 45.70 ?  118 HIS A O   1 
ATOM   858  C CB  . HIS A 1 128 ? 71.344 1.767   38.593  1.00 43.22 ?  118 HIS A CB  1 
ATOM   859  C CG  . HIS A 1 128 ? 72.840 1.895   38.580  1.00 43.16 ?  118 HIS A CG  1 
ATOM   860  N ND1 . HIS A 1 128 ? 73.659 1.215   39.458  1.00 47.50 ?  118 HIS A ND1 1 
ATOM   861  C CD2 . HIS A 1 128 ? 73.664 2.620   37.782  1.00 41.71 ?  118 HIS A CD2 1 
ATOM   862  C CE1 . HIS A 1 128 ? 74.921 1.506   39.193  1.00 44.07 ?  118 HIS A CE1 1 
ATOM   863  N NE2 . HIS A 1 128 ? 74.952 2.357   38.182  1.00 42.39 ?  118 HIS A NE2 1 
ATOM   864  N N   . GLU A 1 129 ? 70.541 4.714   38.738  1.00 42.67 ?  119 GLU A N   1 
ATOM   865  C CA  . GLU A 1 129 ? 70.957 6.107   38.590  1.00 47.32 ?  119 GLU A CA  1 
ATOM   866  C C   . GLU A 1 129 ? 70.371 6.991   39.683  1.00 50.11 ?  119 GLU A C   1 
ATOM   867  O O   . GLU A 1 129 ? 71.082 7.812   40.272  1.00 42.82 ?  119 GLU A O   1 
ATOM   868  C CB  . GLU A 1 129 ? 70.574 6.628   37.206  1.00 40.42 ?  119 GLU A CB  1 
ATOM   869  C CG  . GLU A 1 129 ? 71.255 5.858   36.087  1.00 51.22 ?  119 GLU A CG  1 
ATOM   870  C CD  . GLU A 1 129 ? 70.844 6.334   34.715  1.00 56.13 ?  119 GLU A CD  1 
ATOM   871  O OE1 . GLU A 1 129 ? 69.738 6.907   34.588  1.00 51.02 ?  119 GLU A OE1 1 
ATOM   872  O OE2 . GLU A 1 129 ? 71.632 6.126   33.765  1.00 56.60 ?  119 GLU A OE2 1 
ATOM   873  N N   . ASP A 1 130 ? 69.078 6.841   39.973  1.00 44.54 ?  120 ASP A N   1 
ATOM   874  C CA  . ASP A 1 130 ? 68.466 7.670   41.007  1.00 46.86 ?  120 ASP A CA  1 
ATOM   875  C C   . ASP A 1 130 ? 69.065 7.424   42.389  1.00 53.10 ?  120 ASP A C   1 
ATOM   876  O O   . ASP A 1 130 ? 68.909 8.270   43.275  1.00 42.91 ?  120 ASP A O   1 
ATOM   877  C CB  . ASP A 1 130 ? 66.955 7.439   41.041  1.00 50.89 ?  120 ASP A CB  1 
ATOM   878  C CG  . ASP A 1 130 ? 66.276 7.870   39.755  1.00 57.10 ?  120 ASP A CG  1 
ATOM   879  O OD1 . ASP A 1 130 ? 66.952 8.517   38.925  1.00 53.05 ?  120 ASP A OD1 1 
ATOM   880  O OD2 . ASP A 1 130 ? 65.073 7.578   39.581  1.00 59.05 ?  120 ASP A OD2 1 
ATOM   881  N N   . ALA A 1 131 ? 69.727 6.283   42.598  1.00 48.15 ?  121 ALA A N   1 
ATOM   882  C CA  . ALA A 1 131 ? 70.384 5.976   43.862  1.00 50.14 ?  121 ALA A CA  1 
ATOM   883  C C   . ALA A 1 131 ? 71.845 6.404   43.886  1.00 53.85 ?  121 ALA A C   1 
ATOM   884  O O   . ALA A 1 131 ? 72.478 6.322   44.946  1.00 51.91 ?  121 ALA A O   1 
ATOM   885  C CB  . ALA A 1 131 ? 70.303 4.474   44.156  1.00 41.93 ?  121 ALA A CB  1 
ATOM   886  N N   . ASN A 1 132 ? 72.385 6.850   42.749  1.00 45.71 ?  122 ASN A N   1 
ATOM   887  C CA  . ASN A 1 132 ? 73.818 7.111   42.596  1.00 43.74 ?  122 ASN A CA  1 
ATOM   888  C C   . ASN A 1 132 ? 74.651 5.899   43.004  1.00 51.30 ?  122 ASN A C   1 
ATOM   889  O O   . ASN A 1 132 ? 75.761 6.037   43.527  1.00 46.54 ?  122 ASN A O   1 
ATOM   890  C CB  . ASN A 1 132 ? 74.253 8.355   43.382  1.00 49.08 ?  122 ASN A CB  1 
ATOM   891  N N   . ALA A 1 133 ? 74.124 4.700   42.755  1.00 43.84 ?  123 ALA A N   1 
ATOM   892  C CA  . ALA A 1 133 ? 74.816 3.482   43.149  1.00 43.28 ?  123 ALA A CA  1 
ATOM   893  C C   . ALA A 1 133 ? 76.051 3.253   42.281  1.00 43.64 ?  123 ALA A C   1 
ATOM   894  O O   . ALA A 1 133 ? 76.156 3.733   41.150  1.00 42.95 ?  123 ALA A O   1 
ATOM   895  C CB  . ALA A 1 133 ? 73.882 2.272   43.059  1.00 44.00 ?  123 ALA A CB  1 
ATOM   896  N N   . GLN A 1 134 ? 77.007 2.517   42.840  1.00 45.21 ?  124 GLN A N   1 
ATOM   897  C CA  . GLN A 1 134 ? 78.105 1.991   42.047  1.00 45.64 ?  124 GLN A CA  1 
ATOM   898  C C   . GLN A 1 134 ? 77.727 0.708   41.315  1.00 48.17 ?  124 GLN A C   1 
ATOM   899  O O   . GLN A 1 134 ? 78.353 0.376   40.297  1.00 44.31 ?  124 GLN A O   1 
ATOM   900  C CB  . GLN A 1 134 ? 79.309 1.717   42.940  1.00 42.75 ?  124 GLN A CB  1 
ATOM   901  C CG  . GLN A 1 134 ? 79.823 2.940   43.663  1.00 51.51 ?  124 GLN A CG  1 
ATOM   902  C CD  . GLN A 1 134 ? 80.954 3.568   42.919  1.00 58.74 ?  124 GLN A CD  1 
ATOM   903  O OE1 . GLN A 1 134 ? 80.839 3.830   41.719  1.00 59.17 ?  124 GLN A OE1 1 
ATOM   904  N NE2 . GLN A 1 134 ? 82.070 3.800   43.606  1.00 68.05 ?  124 GLN A NE2 1 
ATOM   905  N N   . ALA A 1 135 ? 76.738 -0.024  41.824  1.00 40.22 ?  125 ALA A N   1 
ATOM   906  C CA  . ALA A 1 135 ? 76.287 -1.258  41.201  1.00 39.05 ?  125 ALA A CA  1 
ATOM   907  C C   . ALA A 1 135 ? 74.909 -1.606  41.747  1.00 42.47 ?  125 ALA A C   1 
ATOM   908  O O   . ALA A 1 135 ? 74.590 -1.297  42.897  1.00 41.29 ?  125 ALA A O   1 
ATOM   909  C CB  . ALA A 1 135 ? 77.282 -2.396  41.451  1.00 37.00 ?  125 ALA A CB  1 
ATOM   910  N N   . THR A 1 136 ? 74.090 -2.234  40.902  1.00 43.88 ?  126 THR A N   1 
ATOM   911  C CA  . THR A 1 136 ? 72.735 -2.637  41.263  1.00 39.45 ?  126 THR A CA  1 
ATOM   912  C C   . THR A 1 136 ? 72.504 -4.050  40.750  1.00 45.17 ?  126 THR A C   1 
ATOM   913  O O   . THR A 1 136 ? 72.820 -4.344  39.593  1.00 39.89 ?  126 THR A O   1 
ATOM   914  C CB  . THR A 1 136 ? 71.677 -1.681  40.674  1.00 39.02 ?  126 THR A CB  1 
ATOM   915  O OG1 . THR A 1 136 ? 71.898 -0.343  41.143  1.00 41.63 ?  126 THR A OG1 1 
ATOM   916  C CG2 . THR A 1 136 ? 70.253 -2.126  41.026  1.00 34.04 ?  126 THR A CG2 1 
ATOM   917  N N   . VAL A 1 137 ? 71.957 -4.920  41.601  1.00 42.87 ?  127 VAL A N   1 
ATOM   918  C CA  . VAL A 1 137 ? 71.662 -6.304  41.228  1.00 41.37 ?  127 VAL A CA  1 
ATOM   919  C C   . VAL A 1 137 ? 70.177 -6.421  40.906  1.00 36.53 ?  127 VAL A C   1 
ATOM   920  O O   . VAL A 1 137 ? 69.328 -6.040  41.720  1.00 36.37 ?  127 VAL A O   1 
ATOM   921  C CB  . VAL A 1 137 ? 72.035 -7.277  42.359  1.00 44.68 ?  127 VAL A CB  1 
ATOM   922  C CG1 . VAL A 1 137 ? 71.676 -8.720  41.968  1.00 39.47 ?  127 VAL A CG1 1 
ATOM   923  C CG2 . VAL A 1 137 ? 73.488 -7.122  42.733  1.00 52.12 ?  127 VAL A CG2 1 
ATOM   924  N N   . LEU A 1 138 ? 69.856 -6.961  39.730  1.00 39.90 ?  128 LEU A N   1 
ATOM   925  C CA  . LEU A 1 138 ? 68.485 -7.389  39.455  1.00 41.41 ?  128 LEU A CA  1 
ATOM   926  C C   . LEU A 1 138 ? 68.204 -8.676  40.223  1.00 41.38 ?  128 LEU A C   1 
ATOM   927  O O   . LEU A 1 138 ? 68.870 -9.694  40.001  1.00 37.93 ?  128 LEU A O   1 
ATOM   928  C CB  . LEU A 1 138 ? 68.275 -7.619  37.959  1.00 40.06 ?  128 LEU A CB  1 
ATOM   929  C CG  . LEU A 1 138 ? 66.883 -8.149  37.570  1.00 40.43 ?  128 LEU A CG  1 
ATOM   930  C CD1 . LEU A 1 138 ? 65.782 -7.210  38.045  1.00 41.46 ?  128 LEU A CD1 1 
ATOM   931  C CD2 . LEU A 1 138 ? 66.797 -8.386  36.056  1.00 38.85 ?  128 LEU A CD2 1 
ATOM   932  N N   . SER A 1 139 ? 67.228 -8.643  41.121  1.00 38.02 ?  129 SER A N   1 
ATOM   933  C CA  . SER A 1 139 ? 66.863 -9.828  41.879  1.00 40.14 ?  129 SER A CA  1 
ATOM   934  C C   . SER A 1 139 ? 65.453 -10.264 41.503  1.00 41.73 ?  129 SER A C   1 
ATOM   935  O O   . SER A 1 139 ? 64.715 -9.540  40.833  1.00 41.16 ?  129 SER A O   1 
ATOM   936  C CB  . SER A 1 139 ? 66.915 -9.570  43.390  1.00 45.21 ?  129 SER A CB  1 
ATOM   937  O OG  . SER A 1 139 ? 65.875 -8.688  43.774  1.00 39.89 ?  129 SER A OG  1 
ATOM   938  N N   . ALA A 1 140 ? 65.076 -11.449 41.995  1.00 44.13 ?  130 ALA A N   1 
ATOM   939  C CA  . ALA A 1 140 ? 63.726 -11.979 41.846  1.00 42.29 ?  130 ALA A CA  1 
ATOM   940  C C   . ALA A 1 140 ? 63.455 -12.962 42.978  1.00 52.25 ?  130 ALA A C   1 
ATOM   941  O O   . ALA A 1 140 ? 64.382 -13.541 43.554  1.00 48.06 ?  130 ALA A O   1 
ATOM   942  C CB  . ALA A 1 140 ? 63.536 -12.658 40.488  1.00 44.79 ?  130 ALA A CB  1 
ATOM   943  N N   . SER A 1 141 ? 62.167 -13.141 43.293  1.00 53.81 ?  131 SER A N   1 
ATOM   944  C CA  . SER A 1 141 ? 61.714 -14.056 44.342  1.00 58.29 ?  131 SER A CA  1 
ATOM   945  C C   . SER A 1 141 ? 61.143 -15.322 43.717  1.00 57.04 ?  131 SER A C   1 
ATOM   946  O O   . SER A 1 141 ? 60.243 -15.246 42.875  1.00 52.38 ?  131 SER A O   1 
ATOM   947  C CB  . SER A 1 141 ? 60.648 -13.405 45.229  1.00 56.19 ?  131 SER A CB  1 
ATOM   948  O OG  . SER A 1 141 ? 61.172 -12.310 45.962  1.00 60.65 ?  131 SER A OG  1 
ATOM   949  N N   . ILE A 1 142 ? 61.656 -16.480 44.140  1.00 54.53 ?  132 ILE A N   1 
ATOM   950  C CA  . ILE A 1 142 ? 61.259 -17.763 43.576  1.00 62.95 ?  132 ILE A CA  1 
ATOM   951  C C   . ILE A 1 142 ? 60.752 -18.674 44.688  1.00 61.19 ?  132 ILE A C   1 
ATOM   952  O O   . ILE A 1 142 ? 61.118 -18.535 45.858  1.00 59.56 ?  132 ILE A O   1 
ATOM   953  C CB  . ILE A 1 142 ? 62.418 -18.436 42.807  1.00 54.11 ?  132 ILE A CB  1 
ATOM   954  N N   . GLN A 1 143 ? 59.897 -19.626 44.300  1.00 68.84 ?  133 GLN A N   1 
ATOM   955  C CA  . GLN A 1 143 ? 59.347 -20.574 45.267  1.00 72.34 ?  133 GLN A CA  1 
ATOM   956  C C   . GLN A 1 143 ? 60.419 -21.539 45.759  1.00 67.94 ?  133 GLN A C   1 
ATOM   957  O O   . GLN A 1 143 ? 60.590 -21.727 46.970  1.00 70.36 ?  133 GLN A O   1 
ATOM   958  C CB  . GLN A 1 143 ? 58.169 -21.338 44.650  1.00 62.93 ?  133 GLN A CB  1 
ATOM   959  N N   . GLN A 1 144 ? 61.157 -22.156 44.834  1.00 63.50 ?  134 GLN A N   1 
ATOM   960  C CA  . GLN A 1 144 ? 62.211 -23.113 45.163  1.00 65.82 ?  134 GLN A CA  1 
ATOM   961  C C   . GLN A 1 144 ? 63.565 -22.461 44.905  1.00 70.71 ?  134 GLN A C   1 
ATOM   962  O O   . GLN A 1 144 ? 64.070 -22.496 43.772  1.00 66.02 ?  134 GLN A O   1 
ATOM   963  C CB  . GLN A 1 144 ? 62.055 -24.394 44.339  1.00 59.51 ?  134 GLN A CB  1 
ATOM   964  N N   . PRO A 1 145 ? 64.190 -21.848 45.914  1.00 62.35 ?  135 PRO A N   1 
ATOM   965  C CA  . PRO A 1 145 ? 65.441 -21.107 45.687  1.00 63.18 ?  135 PRO A CA  1 
ATOM   966  C C   . PRO A 1 145 ? 66.678 -21.980 45.576  1.00 66.87 ?  135 PRO A C   1 
ATOM   967  O O   . PRO A 1 145 ? 67.780 -21.429 45.448  1.00 54.73 ?  135 PRO A O   1 
ATOM   968  C CB  . PRO A 1 145 ? 65.557 -20.200 46.929  1.00 67.82 ?  135 PRO A CB  1 
ATOM   969  C CG  . PRO A 1 145 ? 64.558 -20.679 47.907  1.00 67.28 ?  135 PRO A CG  1 
ATOM   970  C CD  . PRO A 1 145 ? 63.595 -21.594 47.238  1.00 67.30 ?  135 PRO A CD  1 
ATOM   971  N N   A TYR A 1 146 ? 66.539 -23.305 45.637  0.60 59.72 ?  136 TYR A N   1 
ATOM   972  C CA  A TYR A 1 146 ? 67.708 -24.167 45.733  0.60 62.24 ?  136 TYR A CA  1 
ATOM   973  C C   A TYR A 1 146 ? 68.676 -23.905 44.592  0.60 54.87 ?  136 TYR A C   1 
ATOM   974  O O   A TYR A 1 146 ? 68.291 -23.895 43.422  0.60 49.52 ?  136 TYR A O   1 
ATOM   975  C CB  A TYR A 1 146 ? 67.308 -25.644 45.744  0.60 61.80 ?  136 TYR A CB  1 
ATOM   976  C CG  A TYR A 1 146 ? 68.526 -26.539 45.805  0.60 66.26 ?  136 TYR A CG  1 
ATOM   977  C CD1 A TYR A 1 146 ? 69.090 -26.886 47.024  0.60 67.25 ?  136 TYR A CD1 1 
ATOM   978  C CD2 A TYR A 1 146 ? 69.125 -27.024 44.643  0.60 68.72 ?  136 TYR A CD2 1 
ATOM   979  C CE1 A TYR A 1 146 ? 70.216 -27.689 47.090  0.60 69.84 ?  136 TYR A CE1 1 
ATOM   980  C CE2 A TYR A 1 146 ? 70.254 -27.830 44.699  0.60 69.31 ?  136 TYR A CE2 1 
ATOM   981  C CZ  A TYR A 1 146 ? 70.791 -28.159 45.928  0.60 69.54 ?  136 TYR A CZ  1 
ATOM   982  O OH  A TYR A 1 146 ? 71.906 -28.958 46.010  0.60 72.65 ?  136 TYR A OH  1 
ATOM   983  N N   . GLY A 1 147 ? 69.940 -23.686 44.943  1.00 60.58 ?  137 GLY A N   1 
ATOM   984  C CA  . GLY A 1 147 ? 71.009 -23.555 43.982  1.00 65.03 ?  137 GLY A CA  1 
ATOM   985  C C   . GLY A 1 147 ? 71.410 -22.131 43.645  1.00 60.85 ?  137 GLY A C   1 
ATOM   986  O O   . GLY A 1 147 ? 72.556 -21.910 43.237  1.00 68.33 ?  137 GLY A O   1 
ATOM   987  N N   . TYR A 1 148 ? 70.511 -21.165 43.798  1.00 66.66 ?  138 TYR A N   1 
ATOM   988  C CA  . TYR A 1 148 ? 70.789 -19.797 43.381  1.00 57.82 ?  138 TYR A CA  1 
ATOM   989  C C   . TYR A 1 148 ? 71.451 -19.002 44.506  1.00 61.28 ?  138 TYR A C   1 
ATOM   990  O O   . TYR A 1 148 ? 71.288 -19.306 45.692  1.00 55.57 ?  138 TYR A O   1 
ATOM   991  C CB  . TYR A 1 148 ? 69.497 -19.109 42.932  1.00 58.39 ?  138 TYR A CB  1 
ATOM   992  N N   . GLY A 1 149 ? 72.219 -17.985 44.117  1.00 61.59 ?  139 GLY A N   1 
ATOM   993  C CA  . GLY A 1 149 ? 72.781 -17.064 45.093  1.00 52.86 ?  139 GLY A CA  1 
ATOM   994  C C   . GLY A 1 149 ? 71.678 -16.252 45.753  1.00 53.94 ?  139 GLY A C   1 
ATOM   995  O O   . GLY A 1 149 ? 70.776 -15.738 45.078  1.00 56.48 ?  139 GLY A O   1 
ATOM   996  N N   . ARG A 1 150 ? 71.744 -16.130 47.077  1.00 55.51 ?  140 ARG A N   1 
ATOM   997  C CA  . ARG A 1 150 ? 70.694 -15.487 47.857  1.00 55.86 ?  140 ARG A CA  1 
ATOM   998  C C   . ARG A 1 150 ? 71.069 -14.046 48.174  1.00 43.58 ?  140 ARG A C   1 
ATOM   999  O O   . ARG A 1 150 ? 72.200 -13.766 48.575  1.00 49.65 ?  140 ARG A O   1 
ATOM   1000 C CB  . ARG A 1 150 ? 70.452 -16.248 49.162  1.00 61.18 ?  140 ARG A CB  1 
ATOM   1001 C CG  . ARG A 1 150 ? 70.278 -17.738 48.964  1.00 57.65 ?  140 ARG A CG  1 
ATOM   1002 C CD  . ARG A 1 150 ? 68.855 -18.081 48.620  1.00 58.66 ?  140 ARG A CD  1 
ATOM   1003 N NE  . ARG A 1 150 ? 68.501 -19.425 49.056  1.00 60.07 ?  140 ARG A NE  1 
ATOM   1004 C CZ  . ARG A 1 150 ? 68.974 -20.540 48.516  1.00 64.32 ?  140 ARG A CZ  1 
ATOM   1005 N NH1 . ARG A 1 150 ? 69.804 -20.512 47.486  1.00 63.11 ?  140 ARG A NH1 1 
ATOM   1006 N NH2 . ARG A 1 150 ? 68.604 -21.713 49.024  1.00 67.56 ?  140 ARG A NH2 1 
ATOM   1007 N N   . ILE A 1 151 ? 70.112 -13.138 48.011  1.00 53.41 ?  141 ILE A N   1 
ATOM   1008 C CA  . ILE A 1 151 ? 70.313 -11.737 48.379  1.00 50.40 ?  141 ILE A CA  1 
ATOM   1009 C C   . ILE A 1 151 ? 70.109 -11.574 49.884  1.00 61.63 ?  141 ILE A C   1 
ATOM   1010 O O   . ILE A 1 151 ? 69.013 -11.805 50.408  1.00 54.59 ?  141 ILE A O   1 
ATOM   1011 C CB  . ILE A 1 151 ? 69.388 -10.800 47.579  1.00 56.10 ?  141 ILE A CB  1 
ATOM   1012 C CG1 . ILE A 1 151 ? 69.972 -10.481 46.194  1.00 55.29 ?  141 ILE A CG1 1 
ATOM   1013 C CG2 . ILE A 1 151 ? 69.157 -9.471  48.322  1.00 49.85 ?  141 ILE A CG2 1 
ATOM   1014 C CD1 . ILE A 1 151 ? 70.377 -11.632 45.392  1.00 49.86 ?  141 ILE A CD1 1 
ATOM   1015 N N   . VAL A 1 152 ? 71.178 -11.196 50.582  1.00 56.21 ?  142 VAL A N   1 
ATOM   1016 C CA  . VAL A 1 152 ? 71.107 -10.752 51.968  1.00 53.87 ?  142 VAL A CA  1 
ATOM   1017 C C   . VAL A 1 152 ? 71.105 -9.234  51.969  1.00 55.34 ?  142 VAL A C   1 
ATOM   1018 O O   . VAL A 1 152 ? 72.065 -8.601  51.509  1.00 52.08 ?  142 VAL A O   1 
ATOM   1019 C CB  . VAL A 1 152 ? 72.273 -11.301 52.805  1.00 56.17 ?  142 VAL A CB  1 
ATOM   1020 C CG1 . VAL A 1 152 ? 72.111 -10.886 54.261  1.00 52.83 ?  142 VAL A CG1 1 
ATOM   1021 C CG2 . VAL A 1 152 ? 72.317 -12.809 52.702  1.00 59.66 ?  142 VAL A CG2 1 
ATOM   1022 N N   . ARG A 1 153 ? 70.031 -8.648  52.477  1.00 42.72 ?  143 ARG A N   1 
ATOM   1023 C CA  . ARG A 1 153 ? 69.934 -7.203  52.522  1.00 47.48 ?  143 ARG A CA  1 
ATOM   1024 C C   . ARG A 1 153 ? 70.409 -6.681  53.877  1.00 53.96 ?  143 ARG A C   1 
ATOM   1025 O O   . ARG A 1 153 ? 70.269 -7.342  54.912  1.00 48.23 ?  143 ARG A O   1 
ATOM   1026 C CB  . ARG A 1 153 ? 68.496 -6.776  52.258  1.00 52.33 ?  143 ARG A CB  1 
ATOM   1027 C CG  . ARG A 1 153 ? 68.222 -6.506  50.804  1.00 47.03 ?  143 ARG A CG  1 
ATOM   1028 C CD  . ARG A 1 153 ? 66.740 -6.343  50.574  1.00 60.03 ?  143 ARG A CD  1 
ATOM   1029 N NE  . ARG A 1 153 ? 66.358 -6.586  49.190  1.00 53.62 ?  143 ARG A NE  1 
ATOM   1030 C CZ  . ARG A 1 153 ? 65.881 -5.644  48.389  1.00 65.22 ?  143 ARG A CZ  1 
ATOM   1031 N NH1 . ARG A 1 153 ? 65.801 -4.382  48.783  1.00 55.12 ?  143 ARG A NH1 1 
ATOM   1032 N NH2 . ARG A 1 153 ? 65.476 -5.975  47.164  1.00 49.62 ?  143 ARG A NH2 1 
ATOM   1033 N N   . ASN A 1 154 ? 70.990 -5.488  53.859  1.00 53.31 ?  144 ASN A N   1 
ATOM   1034 C CA  . ASN A 1 154 ? 71.410 -4.837  55.092  1.00 52.77 ?  144 ASN A CA  1 
ATOM   1035 C C   . ASN A 1 154 ? 70.235 -4.056  55.689  1.00 55.67 ?  144 ASN A C   1 
ATOM   1036 O O   . ASN A 1 154 ? 69.100 -4.108  55.198  1.00 49.15 ?  144 ASN A O   1 
ATOM   1037 C CB  . ASN A 1 154 ? 72.683 -4.019  54.836  1.00 55.19 ?  144 ASN A CB  1 
ATOM   1038 C CG  . ASN A 1 154 ? 72.424 -2.639  54.206  1.00 53.53 ?  144 ASN A CG  1 
ATOM   1039 O OD1 . ASN A 1 154 ? 71.301 -2.138  54.140  1.00 55.52 ?  144 ASN A OD1 1 
ATOM   1040 N ND2 . ASN A 1 154 ? 73.501 -2.023  53.731  1.00 64.20 ?  144 ASN A ND2 1 
ATOM   1041 N N   . ALA A 1 155 ? 70.511 -3.315  56.769  1.00 47.21 ?  145 ALA A N   1 
ATOM   1042 C CA  . ALA A 1 155 ? 69.458 -2.591  57.474  1.00 52.87 ?  145 ALA A CA  1 
ATOM   1043 C C   . ALA A 1 155 ? 68.870 -1.465  56.626  1.00 55.72 ?  145 ALA A C   1 
ATOM   1044 O O   . ALA A 1 155 ? 67.719 -1.070  56.842  1.00 50.83 ?  145 ALA A O   1 
ATOM   1045 C CB  . ALA A 1 155 ? 69.999 -2.038  58.801  1.00 50.71 ?  145 ALA A CB  1 
ATOM   1046 N N   . SER A 1 156 ? 69.633 -0.935  55.671  1.00 50.17 ?  146 SER A N   1 
ATOM   1047 C CA  . SER A 1 156 ? 69.163 0.140   54.805  1.00 49.91 ?  146 SER A CA  1 
ATOM   1048 C C   . SER A 1 156 ? 68.379 -0.365  53.597  1.00 53.40 ?  146 SER A C   1 
ATOM   1049 O O   . SER A 1 156 ? 67.923 0.446   52.781  1.00 58.54 ?  146 SER A O   1 
ATOM   1050 C CB  . SER A 1 156 ? 70.354 0.983   54.329  1.00 55.11 ?  146 SER A CB  1 
ATOM   1051 O OG  . SER A 1 156 ? 70.647 2.016   55.254  1.00 69.79 ?  146 SER A OG  1 
ATOM   1052 N N   . GLY A 1 157 ? 68.210 -1.674  53.457  1.00 45.48 ?  147 GLY A N   1 
ATOM   1053 C CA  . GLY A 1 157 ? 67.597 -2.233  52.272  1.00 56.52 ?  147 GLY A CA  1 
ATOM   1054 C C   . GLY A 1 157 ? 68.549 -2.480  51.121  1.00 55.50 ?  147 GLY A C   1 
ATOM   1055 O O   . GLY A 1 157 ? 68.132 -3.050  50.103  1.00 53.41 ?  147 GLY A O   1 
ATOM   1056 N N   . ARG A 1 158 ? 69.814 -2.086  51.258  1.00 55.65 ?  148 ARG A N   1 
ATOM   1057 C CA  . ARG A 1 158 ? 70.823 -2.274  50.229  1.00 57.30 ?  148 ARG A CA  1 
ATOM   1058 C C   . ARG A 1 158 ? 71.448 -3.665  50.360  1.00 54.43 ?  148 ARG A C   1 
ATOM   1059 O O   . ARG A 1 158 ? 71.169 -4.426  51.294  1.00 48.05 ?  148 ARG A O   1 
ATOM   1060 C CB  . ARG A 1 158 ? 71.873 -1.169  50.330  1.00 51.49 ?  148 ARG A CB  1 
ATOM   1061 C CG  . ARG A 1 158 ? 71.316 0.199   49.999  1.00 57.27 ?  148 ARG A CG  1 
ATOM   1062 C CD  . ARG A 1 158 ? 72.241 1.311   50.467  1.00 56.99 ?  148 ARG A CD  1 
ATOM   1063 N NE  . ARG A 1 158 ? 71.761 2.612   50.018  1.00 65.92 ?  148 ARG A NE  1 
ATOM   1064 C CZ  . ARG A 1 158 ? 72.310 3.770   50.358  1.00 72.27 ?  148 ARG A CZ  1 
ATOM   1065 N NH1 . ARG A 1 158 ? 73.342 3.828   51.187  1.00 72.50 ?  148 ARG A NH1 1 
ATOM   1066 N NH2 . ARG A 1 158 ? 71.804 4.898   49.864  1.00 65.80 ?  148 ARG A NH2 1 
ATOM   1067 N N   . LEU A 1 159 ? 72.321 -3.998  49.417  1.00 44.95 ?  149 LEU A N   1 
ATOM   1068 C CA  . LEU A 1 159 ? 72.899 -5.332  49.380  1.00 46.30 ?  149 LEU A CA  1 
ATOM   1069 C C   . LEU A 1 159 ? 73.948 -5.488  50.470  1.00 49.13 ?  149 LEU A C   1 
ATOM   1070 O O   . LEU A 1 159 ? 74.857 -4.660  50.597  1.00 40.60 ?  149 LEU A O   1 
ATOM   1071 C CB  . LEU A 1 159 ? 73.529 -5.602  48.017  1.00 40.35 ?  149 LEU A CB  1 
ATOM   1072 C CG  . LEU A 1 159 ? 74.159 -6.986  47.861  1.00 55.16 ?  149 LEU A CG  1 
ATOM   1073 C CD1 . LEU A 1 159 ? 73.077 -8.082  47.915  1.00 45.46 ?  149 LEU A CD1 1 
ATOM   1074 C CD2 . LEU A 1 159 ? 75.000 -7.073  46.592  1.00 41.14 ?  149 LEU A CD2 1 
ATOM   1075 N N   . GLU A 1 160 ? 73.825 -6.559  51.252  1.00 45.52 ?  150 GLU A N   1 
ATOM   1076 C CA  . GLU A 1 160 ? 74.868 -6.939  52.194  1.00 50.35 ?  150 GLU A CA  1 
ATOM   1077 C C   . GLU A 1 160 ? 75.847 -7.932  51.568  1.00 57.33 ?  150 GLU A C   1 
ATOM   1078 O O   . GLU A 1 160 ? 77.065 -7.737  51.638  1.00 56.90 ?  150 GLU A O   1 
ATOM   1079 C CB  . GLU A 1 160 ? 74.247 -7.540  53.455  1.00 52.48 ?  150 GLU A CB  1 
ATOM   1080 C CG  . GLU A 1 160 ? 75.257 -7.980  54.489  1.00 59.64 ?  150 GLU A CG  1 
ATOM   1081 C CD  . GLU A 1 160 ? 75.474 -6.924  55.549  1.00 72.78 ?  150 GLU A CD  1 
ATOM   1082 O OE1 . GLU A 1 160 ? 75.420 -5.717  55.216  1.00 73.86 ?  150 GLU A OE1 1 
ATOM   1083 O OE2 . GLU A 1 160 ? 75.677 -7.305  56.720  1.00 82.74 ?  150 GLU A OE2 1 
ATOM   1084 N N   . ARG A 1 161 ? 75.328 -8.992  50.948  1.00 53.18 ?  151 ARG A N   1 
ATOM   1085 C CA  . ARG A 1 161 ? 76.148 -10.000 50.290  1.00 57.95 ?  151 ARG A CA  1 
ATOM   1086 C C   . ARG A 1 161 ? 75.245 -10.935 49.496  1.00 54.38 ?  151 ARG A C   1 
ATOM   1087 O O   . ARG A 1 161 ? 74.064 -11.106 49.823  1.00 53.54 ?  151 ARG A O   1 
ATOM   1088 C CB  . ARG A 1 161 ? 76.989 -10.793 51.306  1.00 60.76 ?  151 ARG A CB  1 
ATOM   1089 C CG  . ARG A 1 161 ? 76.204 -11.844 52.051  1.00 59.44 ?  151 ARG A CG  1 
ATOM   1090 C CD  . ARG A 1 161 ? 77.018 -12.541 53.141  1.00 71.43 ?  151 ARG A CD  1 
ATOM   1091 N NE  . ARG A 1 161 ? 76.220 -12.679 54.351  1.00 75.35 ?  151 ARG A NE  1 
ATOM   1092 C CZ  . ARG A 1 161 ? 76.433 -12.003 55.471  1.00 80.35 ?  151 ARG A CZ  1 
ATOM   1093 N NH1 . ARG A 1 161 ? 77.522 -11.266 55.637  1.00 82.55 ?  151 ARG A NH1 1 
ATOM   1094 N NH2 . ARG A 1 161 ? 75.531 -12.065 56.447  1.00 77.20 ?  151 ARG A NH2 1 
ATOM   1095 N N   . ILE A 1 162 ? 75.813 -11.520 48.444  1.00 52.88 ?  152 ILE A N   1 
ATOM   1096 C CA  . ILE A 1 162 ? 75.182 -12.597 47.688  1.00 53.29 ?  152 ILE A CA  1 
ATOM   1097 C C   . ILE A 1 162 ? 75.789 -13.906 48.174  1.00 61.26 ?  152 ILE A C   1 
ATOM   1098 O O   . ILE A 1 162 ? 76.954 -14.198 47.887  1.00 56.15 ?  152 ILE A O   1 
ATOM   1099 C CB  . ILE A 1 162 ? 75.384 -12.433 46.176  1.00 54.18 ?  152 ILE A CB  1 
ATOM   1100 C CG1 . ILE A 1 162 ? 74.846 -11.087 45.700  1.00 46.55 ?  152 ILE A CG1 1 
ATOM   1101 C CG2 . ILE A 1 162 ? 74.744 -13.604 45.418  1.00 46.46 ?  152 ILE A CG2 1 
ATOM   1102 C CD1 . ILE A 1 162 ? 74.767 -10.976 44.197  1.00 49.78 ?  152 ILE A CD1 1 
ATOM   1103 N N   . VAL A 1 163 ? 75.011 -14.701 48.902  1.00 54.92 ?  153 VAL A N   1 
ATOM   1104 C CA  . VAL A 1 163 ? 75.491 -15.977 49.425  1.00 59.61 ?  153 VAL A CA  1 
ATOM   1105 C C   . VAL A 1 163 ? 75.147 -17.082 48.438  1.00 64.80 ?  153 VAL A C   1 
ATOM   1106 O O   . VAL A 1 163 ? 73.966 -17.375 48.204  1.00 57.69 ?  153 VAL A O   1 
ATOM   1107 C CB  . VAL A 1 163 ? 74.894 -16.278 50.806  1.00 64.22 ?  153 VAL A CB  1 
ATOM   1108 C CG1 . VAL A 1 163 ? 75.733 -17.333 51.522  1.00 66.97 ?  153 VAL A CG1 1 
ATOM   1109 C CG2 . VAL A 1 163 ? 74.822 -15.022 51.625  1.00 61.41 ?  153 VAL A CG2 1 
ATOM   1110 N N   . GLU A 1 164 ? 76.174 -17.698 47.860  1.00 61.21 ?  154 GLU A N   1 
ATOM   1111 C CA  . GLU A 1 164 ? 75.944 -18.876 47.043  1.00 70.13 ?  154 GLU A CA  1 
ATOM   1112 C C   . GLU A 1 164 ? 75.538 -20.034 47.948  1.00 72.25 ?  154 GLU A C   1 
ATOM   1113 O O   . GLU A 1 164 ? 75.861 -20.058 49.139  1.00 73.62 ?  154 GLU A O   1 
ATOM   1114 C CB  . GLU A 1 164 ? 77.195 -19.231 46.232  1.00 68.42 ?  154 GLU A CB  1 
ATOM   1115 C CG  . GLU A 1 164 ? 77.553 -18.204 45.149  1.00 66.14 ?  154 GLU A CG  1 
ATOM   1116 C CD  . GLU A 1 164 ? 76.603 -18.214 43.953  1.00 70.51 ?  154 GLU A CD  1 
ATOM   1117 O OE1 . GLU A 1 164 ? 75.906 -19.230 43.728  1.00 70.76 ?  154 GLU A OE1 1 
ATOM   1118 O OE2 . GLU A 1 164 ? 76.557 -17.192 43.233  1.00 68.17 -1 154 GLU A OE2 1 
ATOM   1119 N N   . GLU A 1 165 ? 74.796 -20.989 47.382  1.00 72.66 ?  155 GLU A N   1 
ATOM   1120 C CA  . GLU A 1 165 ? 74.263 -22.073 48.205  1.00 78.06 ?  155 GLU A CA  1 
ATOM   1121 C C   . GLU A 1 165 ? 75.380 -22.934 48.790  1.00 83.17 ?  155 GLU A C   1 
ATOM   1122 O O   . GLU A 1 165 ? 75.280 -23.397 49.935  1.00 76.88 ?  155 GLU A O   1 
ATOM   1123 C CB  . GLU A 1 165 ? 73.298 -22.935 47.395  1.00 72.01 ?  155 GLU A CB  1 
ATOM   1124 C CG  . GLU A 1 165 ? 72.696 -24.056 48.220  1.00 73.00 ?  155 GLU A CG  1 
ATOM   1125 C CD  . GLU A 1 165 ? 71.193 -23.964 48.328  1.00 72.86 ?  155 GLU A CD  1 
ATOM   1126 O OE1 . GLU A 1 165 ? 70.561 -23.477 47.367  1.00 74.49 ?  155 GLU A OE1 1 
ATOM   1127 O OE2 . GLU A 1 165 ? 70.647 -24.370 49.377  1.00 72.95 ?  155 GLU A OE2 1 
ATOM   1128 N N   . LYS A 1 166 ? 76.459 -23.145 48.024  1.00 80.56 ?  156 LYS A N   1 
ATOM   1129 C CA  . LYS A 1 166 ? 77.577 -23.967 48.481  1.00 76.31 ?  156 LYS A CA  1 
ATOM   1130 C C   . LYS A 1 166 ? 78.229 -23.432 49.751  1.00 78.72 ?  156 LYS A C   1 
ATOM   1131 O O   . LYS A 1 166 ? 78.916 -24.191 50.443  1.00 81.69 ?  156 LYS A O   1 
ATOM   1132 C CB  . LYS A 1 166 ? 78.631 -24.084 47.376  1.00 68.27 ?  156 LYS A CB  1 
ATOM   1133 N N   . ASP A 1 167 ? 78.036 -22.154 50.079  1.00 74.01 ?  157 ASP A N   1 
ATOM   1134 C CA  . ASP A 1 167 ? 78.661 -21.535 51.247  1.00 77.46 ?  157 ASP A CA  1 
ATOM   1135 C C   . ASP A 1 167 ? 77.635 -20.744 52.059  1.00 77.79 ?  157 ASP A C   1 
ATOM   1136 O O   . ASP A 1 167 ? 77.877 -19.610 52.478  1.00 84.07 ?  157 ASP A O   1 
ATOM   1137 C CB  . ASP A 1 167 ? 79.825 -20.645 50.812  1.00 74.26 ?  157 ASP A CB  1 
ATOM   1138 N N   . ALA A 1 168 ? 76.475 -21.350 52.316  1.00 74.95 ?  158 ALA A N   1 
ATOM   1139 C CA  . ALA A 1 168 ? 75.350 -20.674 52.953  1.00 75.61 ?  158 ALA A CA  1 
ATOM   1140 C C   . ALA A 1 168 ? 74.928 -21.398 54.223  1.00 76.31 ?  158 ALA A C   1 
ATOM   1141 O O   . ALA A 1 168 ? 74.822 -22.628 54.242  1.00 74.81 ?  158 ALA A O   1 
ATOM   1142 C CB  . ALA A 1 168 ? 74.150 -20.585 52.007  1.00 69.54 ?  158 ALA A CB  1 
ATOM   1143 N N   . THR A 1 169 ? 74.669 -20.629 55.279  1.00 76.26 ?  159 THR A N   1 
ATOM   1144 C CA  . THR A 1 169 ? 74.118 -21.216 56.489  1.00 75.54 ?  159 THR A CA  1 
ATOM   1145 C C   . THR A 1 169 ? 72.654 -21.592 56.273  1.00 77.40 ?  159 THR A C   1 
ATOM   1146 O O   . THR A 1 169 ? 72.007 -21.152 55.318  1.00 76.09 ?  159 THR A O   1 
ATOM   1147 C CB  . THR A 1 169 ? 74.248 -20.262 57.681  1.00 79.26 ?  159 THR A CB  1 
ATOM   1148 O OG1 . THR A 1 169 ? 73.409 -20.715 58.749  1.00 85.60 ?  159 THR A OG1 1 
ATOM   1149 C CG2 . THR A 1 169 ? 73.819 -18.868 57.316  1.00 74.70 ?  159 THR A CG2 1 
ATOM   1150 N N   . GLN A 1 170 ? 72.136 -22.422 57.185  1.00 75.22 ?  160 GLN A N   1 
ATOM   1151 C CA  . GLN A 1 170 ? 70.770 -22.926 57.057  1.00 77.34 ?  160 GLN A CA  1 
ATOM   1152 C C   . GLN A 1 170 ? 69.746 -21.797 57.005  1.00 72.59 ?  160 GLN A C   1 
ATOM   1153 O O   . GLN A 1 170 ? 68.709 -21.931 56.342  1.00 71.03 ?  160 GLN A O   1 
ATOM   1154 C CB  . GLN A 1 170 ? 70.456 -23.878 58.213  1.00 70.63 ?  160 GLN A CB  1 
ATOM   1155 N N   . ALA A 1 171 ? 70.016 -20.682 57.688  1.00 70.44 ?  161 ALA A N   1 
ATOM   1156 C CA  . ALA A 1 171 ? 69.121 -19.532 57.614  1.00 74.70 ?  161 ALA A CA  1 
ATOM   1157 C C   . ALA A 1 171 ? 69.094 -18.951 56.207  1.00 68.38 ?  161 ALA A C   1 
ATOM   1158 O O   . ALA A 1 171 ? 68.029 -18.833 55.592  1.00 65.50 ?  161 ALA A O   1 
ATOM   1159 C CB  . ALA A 1 171 ? 69.546 -18.465 58.624  1.00 69.11 ?  161 ALA A CB  1 
ATOM   1160 N N   . GLU A 1 172 ? 70.266 -18.598 55.676  1.00 72.44 ?  162 GLU A N   1 
ATOM   1161 C CA  . GLU A 1 172 ? 70.331 -17.976 54.360  1.00 67.93 ?  162 GLU A CA  1 
ATOM   1162 C C   . GLU A 1 172 ? 69.674 -18.844 53.291  1.00 68.29 ?  162 GLU A C   1 
ATOM   1163 O O   . GLU A 1 172 ? 69.164 -18.321 52.294  1.00 65.94 ?  162 GLU A O   1 
ATOM   1164 C CB  . GLU A 1 172 ? 71.790 -17.678 53.997  1.00 69.55 ?  162 GLU A CB  1 
ATOM   1165 C CG  . GLU A 1 172 ? 72.374 -16.457 54.704  1.00 70.87 ?  162 GLU A CG  1 
ATOM   1166 C CD  . GLU A 1 172 ? 73.853 -16.598 55.036  1.00 78.90 ?  162 GLU A CD  1 
ATOM   1167 O OE1 . GLU A 1 172 ? 74.490 -17.567 54.560  1.00 80.11 ?  162 GLU A OE1 1 
ATOM   1168 O OE2 . GLU A 1 172 ? 74.381 -15.740 55.778  1.00 78.55 -1 162 GLU A OE2 1 
ATOM   1169 N N   . LYS A 1 173 ? 69.660 -20.165 53.489  1.00 66.33 ?  163 LYS A N   1 
ATOM   1170 C CA  . LYS A 1 173 ? 69.074 -21.077 52.515  1.00 68.12 ?  163 LYS A CA  1 
ATOM   1171 C C   . LYS A 1 173 ? 67.566 -20.900 52.382  1.00 66.78 ?  163 LYS A C   1 
ATOM   1172 O O   . LYS A 1 173 ? 66.998 -21.302 51.362  1.00 62.41 ?  163 LYS A O   1 
ATOM   1173 C CB  . LYS A 1 173 ? 69.388 -22.525 52.899  1.00 71.26 ?  163 LYS A CB  1 
ATOM   1174 C CG  . LYS A 1 173 ? 70.870 -22.835 53.033  1.00 72.79 ?  163 LYS A CG  1 
ATOM   1175 C CD  . LYS A 1 173 ? 71.120 -24.327 53.190  1.00 70.81 ?  163 LYS A CD  1 
ATOM   1176 C CE  . LYS A 1 173 ? 72.582 -24.653 52.930  1.00 75.92 ?  163 LYS A CE  1 
ATOM   1177 N NZ  . LYS A 1 173 ? 72.750 -25.870 52.084  1.00 78.16 ?  163 LYS A NZ  1 
ATOM   1178 N N   . ASP A 1 174 ? 66.907 -20.317 53.384  1.00 64.43 ?  164 ASP A N   1 
ATOM   1179 C CA  . ASP A 1 174 ? 65.468 -20.092 53.322  1.00 68.85 ?  164 ASP A CA  1 
ATOM   1180 C C   . ASP A 1 174 ? 65.094 -18.811 52.585  1.00 65.98 ?  164 ASP A C   1 
ATOM   1181 O O   . ASP A 1 174 ? 63.903 -18.574 52.360  1.00 65.25 ?  164 ASP A O   1 
ATOM   1182 C CB  . ASP A 1 174 ? 64.876 -20.054 54.734  1.00 71.12 ?  164 ASP A CB  1 
ATOM   1183 C CG  . ASP A 1 174 ? 64.880 -21.418 55.410  1.00 76.78 ?  164 ASP A CG  1 
ATOM   1184 O OD1 . ASP A 1 174 ? 64.484 -22.417 54.766  1.00 77.74 ?  164 ASP A OD1 1 
ATOM   1185 O OD2 . ASP A 1 174 ? 65.277 -21.486 56.592  1.00 76.15 ?  164 ASP A OD2 1 
ATOM   1186 N N   . ILE A 1 175 ? 66.072 -17.983 52.217  1.00 64.31 ?  165 ILE A N   1 
ATOM   1187 C CA  . ILE A 1 175 ? 65.787 -16.761 51.470  1.00 70.75 ?  165 ILE A CA  1 
ATOM   1188 C C   . ILE A 1 175 ? 65.224 -17.120 50.101  1.00 61.53 ?  165 ILE A C   1 
ATOM   1189 O O   . ILE A 1 175 ? 65.771 -17.977 49.392  1.00 57.50 ?  165 ILE A O   1 
ATOM   1190 C CB  . ILE A 1 175 ? 67.055 -15.898 51.352  1.00 65.70 ?  165 ILE A CB  1 
ATOM   1191 C CG1 . ILE A 1 175 ? 67.539 -15.468 52.745  1.00 65.18 ?  165 ILE A CG1 1 
ATOM   1192 C CG2 . ILE A 1 175 ? 66.826 -14.710 50.424  1.00 52.53 ?  165 ILE A CG2 1 
ATOM   1193 C CD1 . ILE A 1 175 ? 68.816 -14.645 52.746  1.00 61.21 ?  165 ILE A CD1 1 
ATOM   1194 N N   . ASN A 1 176 ? 64.113 -16.472 49.730  1.00 53.91 ?  166 ASN A N   1 
ATOM   1195 C CA  . ASN A 1 176 ? 63.492 -16.672 48.423  1.00 62.03 ?  166 ASN A CA  1 
ATOM   1196 C C   . ASN A 1 176 ? 63.974 -15.681 47.369  1.00 58.01 ?  166 ASN A C   1 
ATOM   1197 O O   . ASN A 1 176 ? 63.763 -15.924 46.173  1.00 53.92 ?  166 ASN A O   1 
ATOM   1198 C CB  . ASN A 1 176 ? 61.962 -16.567 48.522  1.00 57.34 ?  166 ASN A CB  1 
ATOM   1199 C CG  . ASN A 1 176 ? 61.402 -17.249 49.757  1.00 72.86 ?  166 ASN A CG  1 
ATOM   1200 O OD1 . ASN A 1 176 ? 61.783 -16.932 50.887  1.00 79.39 ?  166 ASN A OD1 1 
ATOM   1201 N ND2 . ASN A 1 176 ? 60.494 -18.198 49.548  1.00 70.61 ?  166 ASN A ND2 1 
ATOM   1202 N N   . GLU A 1 177 ? 64.595 -14.571 47.782  1.00 51.10 ?  167 GLU A N   1 
ATOM   1203 C CA  . GLU A 1 177 ? 65.107 -13.569 46.851  1.00 52.76 ?  167 GLU A CA  1 
ATOM   1204 C C   . GLU A 1 177 ? 66.483 -13.996 46.354  1.00 50.23 ?  167 GLU A C   1 
ATOM   1205 O O   . GLU A 1 177 ? 67.400 -14.208 47.160  1.00 48.29 ?  167 GLU A O   1 
ATOM   1206 C CB  . GLU A 1 177 ? 65.171 -12.199 47.527  1.00 45.71 ?  167 GLU A CB  1 
ATOM   1207 C CG  . GLU A 1 177 ? 64.887 -11.016 46.600  1.00 52.78 ?  167 GLU A CG  1 
ATOM   1208 C CD  . GLU A 1 177 ? 65.402 -9.682  47.150  1.00 56.78 ?  167 GLU A CD  1 
ATOM   1209 O OE1 . GLU A 1 177 ? 65.753 -9.622  48.350  1.00 51.76 ?  167 GLU A OE1 1 
ATOM   1210 O OE2 . GLU A 1 177 ? 65.440 -8.689  46.384  1.00 50.13 -1 167 GLU A OE2 1 
ATOM   1211 N N   . ILE A 1 178 ? 66.641 -14.110 45.031  1.00 43.08 ?  168 ILE A N   1 
ATOM   1212 C CA  . ILE A 1 178 ? 67.879 -14.627 44.466  1.00 47.93 ?  168 ILE A CA  1 
ATOM   1213 C C   . ILE A 1 178 ? 68.462 -13.612 43.478  1.00 42.40 ?  168 ILE A C   1 
ATOM   1214 O O   . ILE A 1 178 ? 67.779 -12.696 43.023  1.00 42.02 ?  168 ILE A O   1 
ATOM   1215 C CB  . ILE A 1 178 ? 67.662 -16.025 43.826  1.00 49.73 ?  168 ILE A CB  1 
ATOM   1216 C CG1 . ILE A 1 178 ? 66.411 -16.121 42.931  1.00 55.89 ?  168 ILE A CG1 1 
ATOM   1217 C CG2 . ILE A 1 178 ? 67.466 -17.058 44.926  1.00 54.43 ?  168 ILE A CG2 1 
ATOM   1218 C CD1 . ILE A 1 178 ? 66.294 -15.127 41.793  1.00 53.86 ?  168 ILE A CD1 1 
ATOM   1219 N N   . SER A 1 179 ? 69.757 -13.760 43.185  1.00 41.89 ?  169 SER A N   1 
ATOM   1220 C CA  . SER A 1 179 ? 70.407 -12.939 42.170  1.00 42.69 ?  169 SER A CA  1 
ATOM   1221 C C   . SER A 1 179 ? 70.042 -13.456 40.785  1.00 48.43 ?  169 SER A C   1 
ATOM   1222 O O   . SER A 1 179 ? 70.116 -14.662 40.531  1.00 44.61 ?  169 SER A O   1 
ATOM   1223 C CB  . SER A 1 179 ? 71.925 -12.957 42.360  1.00 46.79 ?  169 SER A CB  1 
ATOM   1224 O OG  . SER A 1 179 ? 72.594 -12.236 41.333  1.00 49.15 ?  169 SER A OG  1 
ATOM   1225 N N   . SER A 1 180 ? 69.637 -12.550 39.891  1.00 41.50 ?  170 SER A N   1 
ATOM   1226 C CA  . SER A 1 180 ? 69.375 -12.938 38.507  1.00 39.54 ?  170 SER A CA  1 
ATOM   1227 C C   . SER A 1 180 ? 70.639 -13.084 37.683  1.00 45.27 ?  170 SER A C   1 
ATOM   1228 O O   . SER A 1 180 ? 70.570 -13.624 36.576  1.00 53.07 ?  170 SER A O   1 
ATOM   1229 C CB  . SER A 1 180 ? 68.498 -11.910 37.800  1.00 43.57 ?  170 SER A CB  1 
ATOM   1230 O OG  . SER A 1 180 ? 69.222 -10.701 37.616  1.00 41.58 ?  170 SER A OG  1 
ATOM   1231 N N   . GLY A 1 181 ? 71.778 -12.593 38.175  1.00 46.93 ?  171 GLY A N   1 
ATOM   1232 C CA  . GLY A 1 181 ? 72.974 -12.499 37.370  1.00 42.22 ?  171 GLY A CA  1 
ATOM   1233 C C   . GLY A 1 181 ? 72.990 -11.336 36.403  1.00 43.30 ?  171 GLY A C   1 
ATOM   1234 O O   . GLY A 1 181 ? 73.939 -11.215 35.616  1.00 43.38 ?  171 GLY A O   1 
ATOM   1235 N N   . ILE A 1 182 ? 71.977 -10.476 36.434  1.00 38.56 ?  172 ILE A N   1 
ATOM   1236 C CA  . ILE A 1 182 ? 71.928 -9.265  35.620  1.00 38.78 ?  172 ILE A CA  1 
ATOM   1237 C C   . ILE A 1 182 ? 72.236 -8.083  36.531  1.00 40.26 ?  172 ILE A C   1 
ATOM   1238 O O   . ILE A 1 182 ? 71.598 -7.924  37.578  1.00 37.34 ?  172 ILE A O   1 
ATOM   1239 C CB  . ILE A 1 182 ? 70.554 -9.111  34.945  1.00 39.61 ?  172 ILE A CB  1 
ATOM   1240 C CG1 . ILE A 1 182 ? 70.346 -10.232 33.916  1.00 39.52 ?  172 ILE A CG1 1 
ATOM   1241 C CG2 . ILE A 1 182 ? 70.396 -7.709  34.334  1.00 39.15 ?  172 ILE A CG2 1 
ATOM   1242 C CD1 . ILE A 1 182 ? 68.929 -10.305 33.355  1.00 42.06 ?  172 ILE A CD1 1 
ATOM   1243 N N   . PHE A 1 183 ? 73.219 -7.264  36.142  1.00 33.66 ?  173 PHE A N   1 
ATOM   1244 C CA  . PHE A 1 183 ? 73.716 -6.169  36.971  1.00 41.67 ?  173 PHE A CA  1 
ATOM   1245 C C   . PHE A 1 183 ? 73.756 -4.874  36.176  1.00 41.27 ?  173 PHE A C   1 
ATOM   1246 O O   . PHE A 1 183 ? 73.907 -4.889  34.951  1.00 39.23 ?  173 PHE A O   1 
ATOM   1247 C CB  . PHE A 1 183 ? 75.143 -6.440  37.495  1.00 35.52 ?  173 PHE A CB  1 
ATOM   1248 C CG  . PHE A 1 183 ? 75.280 -7.722  38.209  1.00 39.08 ?  173 PHE A CG  1 
ATOM   1249 C CD1 . PHE A 1 183 ? 74.841 -7.854  39.509  1.00 37.47 ?  173 PHE A CD1 1 
ATOM   1250 C CD2 . PHE A 1 183 ? 75.833 -8.824  37.566  1.00 46.21 ?  173 PHE A CD2 1 
ATOM   1251 C CE1 . PHE A 1 183 ? 74.954 -9.073  40.171  1.00 50.81 ?  173 PHE A CE1 1 
ATOM   1252 C CE2 . PHE A 1 183 ? 75.954 -10.036 38.218  1.00 52.66 ?  173 PHE A CE2 1 
ATOM   1253 C CZ  . PHE A 1 183 ? 75.517 -10.160 39.529  1.00 48.83 ?  173 PHE A CZ  1 
ATOM   1254 N N   . ALA A 1 184 ? 73.644 -3.755  36.892  1.00 39.18 ?  174 ALA A N   1 
ATOM   1255 C CA  . ALA A 1 184 ? 73.954 -2.424  36.370  1.00 41.91 ?  174 ALA A CA  1 
ATOM   1256 C C   . ALA A 1 184 ? 75.136 -1.860  37.148  1.00 44.65 ?  174 ALA A C   1 
ATOM   1257 O O   . ALA A 1 184 ? 75.171 -1.963  38.380  1.00 47.00 ?  174 ALA A O   1 
ATOM   1258 C CB  . ALA A 1 184 ? 72.752 -1.488  36.489  1.00 41.65 ?  174 ALA A CB  1 
ATOM   1259 N N   . PHE A 1 185 ? 76.103 -1.267  36.438  1.00 40.78 ?  175 PHE A N   1 
ATOM   1260 C CA  . PHE A 1 185 ? 77.341 -0.792  37.048  1.00 40.39 ?  175 PHE A CA  1 
ATOM   1261 C C   . PHE A 1 185 ? 77.587 0.671   36.696  1.00 42.37 ?  175 PHE A C   1 
ATOM   1262 O O   . PHE A 1 185 ? 77.223 1.140   35.613  1.00 40.19 ?  175 PHE A O   1 
ATOM   1263 C CB  . PHE A 1 185 ? 78.583 -1.598  36.577  1.00 40.56 ?  175 PHE A CB  1 
ATOM   1264 C CG  . PHE A 1 185 ? 78.620 -3.036  37.048  1.00 42.28 ?  175 PHE A CG  1 
ATOM   1265 C CD1 . PHE A 1 185 ? 78.917 -3.344  38.367  1.00 36.32 ?  175 PHE A CD1 1 
ATOM   1266 C CD2 . PHE A 1 185 ? 78.401 -4.078  36.155  1.00 44.76 ?  175 PHE A CD2 1 
ATOM   1267 C CE1 . PHE A 1 185 ? 78.969 -4.660  38.807  1.00 40.29 ?  175 PHE A CE1 1 
ATOM   1268 C CE2 . PHE A 1 185 ? 78.459 -5.411  36.579  1.00 43.46 ?  175 PHE A CE2 1 
ATOM   1269 C CZ  . PHE A 1 185 ? 78.740 -5.700  37.910  1.00 43.52 ?  175 PHE A CZ  1 
ATOM   1270 N N   . ASN A 1 186 ? 78.235 1.389   37.612  1.00 44.82 ?  176 ASN A N   1 
ATOM   1271 C CA  . ASN A 1 186 ? 78.978 2.573   37.209  1.00 45.86 ?  176 ASN A CA  1 
ATOM   1272 C C   . ASN A 1 186 ? 80.117 2.098   36.312  1.00 47.01 ?  176 ASN A C   1 
ATOM   1273 O O   . ASN A 1 186 ? 80.930 1.261   36.730  1.00 49.20 ?  176 ASN A O   1 
ATOM   1274 C CB  . ASN A 1 186 ? 79.483 3.325   38.445  1.00 48.69 ?  176 ASN A CB  1 
ATOM   1275 C CG  . ASN A 1 186 ? 80.397 4.503   38.106  1.00 53.70 ?  176 ASN A CG  1 
ATOM   1276 O OD1 . ASN A 1 186 ? 81.196 4.453   37.172  1.00 48.74 ?  176 ASN A OD1 1 
ATOM   1277 N ND2 . ASN A 1 186 ? 80.240 5.592   38.852  1.00 50.71 ?  176 ASN A ND2 1 
ATOM   1278 N N   . ASN A 1 187 ? 80.157 2.589   35.065  1.00 43.98 ?  177 ASN A N   1 
ATOM   1279 C CA  . ASN A 1 187 ? 81.073 2.000   34.088  1.00 45.59 ?  177 ASN A CA  1 
ATOM   1280 C C   . ASN A 1 187 ? 82.523 2.161   34.507  1.00 47.81 ?  177 ASN A C   1 
ATOM   1281 O O   . ASN A 1 187 ? 83.342 1.253   34.296  1.00 43.57 ?  177 ASN A O   1 
ATOM   1282 C CB  . ASN A 1 187 ? 80.877 2.599   32.697  1.00 45.41 ?  177 ASN A CB  1 
ATOM   1283 C CG  . ASN A 1 187 ? 81.749 1.897   31.644  1.00 55.28 ?  177 ASN A CG  1 
ATOM   1284 O OD1 . ASN A 1 187 ? 81.552 0.711   31.334  1.00 48.81 ?  177 ASN A OD1 1 
ATOM   1285 N ND2 . ASN A 1 187 ? 82.746 2.615   31.129  1.00 48.03 ?  177 ASN A ND2 1 
ATOM   1286 N N   . LYS A 1 188 ? 82.870 3.319   35.071  1.00 45.47 ?  178 LYS A N   1 
ATOM   1287 C CA  . LYS A 1 188 ? 84.243 3.533   35.516  1.00 51.53 ?  178 LYS A CA  1 
ATOM   1288 C C   . LYS A 1 188 ? 84.604 2.565   36.635  1.00 45.96 ?  178 LYS A C   1 
ATOM   1289 O O   . LYS A 1 188 ? 85.654 1.915   36.595  1.00 44.81 ?  178 LYS A O   1 
ATOM   1290 C CB  . LYS A 1 188 ? 84.433 4.988   35.962  1.00 45.42 ?  178 LYS A CB  1 
ATOM   1291 N N   . THR A 1 189 ? 83.731 2.442   37.641  1.00 43.80 ?  179 THR A N   1 
ATOM   1292 C CA  . THR A 1 189 ? 83.998 1.514   38.734  1.00 42.50 ?  179 THR A CA  1 
ATOM   1293 C C   . THR A 1 189 ? 84.154 0.086   38.230  1.00 50.82 ?  179 THR A C   1 
ATOM   1294 O O   . THR A 1 189 ? 85.072 -0.631  38.650  1.00 49.89 ?  179 THR A O   1 
ATOM   1295 C CB  . THR A 1 189 ? 82.880 1.582   39.771  1.00 50.41 ?  179 THR A CB  1 
ATOM   1296 O OG1 . THR A 1 189 ? 82.519 2.946   39.982  1.00 54.83 ?  179 THR A OG1 1 
ATOM   1297 C CG2 . THR A 1 189 ? 83.338 0.971   41.083  1.00 52.85 ?  179 THR A CG2 1 
ATOM   1298 N N   . LEU A 1 190 ? 83.274 -0.338  37.316  1.00 46.50 ?  180 LEU A N   1 
ATOM   1299 C CA  . LEU A 1 190 ? 83.265 -1.729  36.879  1.00 38.54 ?  180 LEU A CA  1 
ATOM   1300 C C   . LEU A 1 190 ? 84.625 -2.140  36.329  1.00 48.42 ?  180 LEU A C   1 
ATOM   1301 O O   . LEU A 1 190 ? 85.194 -3.158  36.740  1.00 46.79 ?  180 LEU A O   1 
ATOM   1302 C CB  . LEU A 1 190 ? 82.167 -1.941  35.836  1.00 36.50 ?  180 LEU A CB  1 
ATOM   1303 C CG  . LEU A 1 190 ? 82.256 -3.244  35.032  1.00 44.07 ?  180 LEU A CG  1 
ATOM   1304 C CD1 . LEU A 1 190 ? 82.079 -4.496  35.911  1.00 48.79 ?  180 LEU A CD1 1 
ATOM   1305 C CD2 . LEU A 1 190 ? 81.234 -3.215  33.900  1.00 49.69 ?  180 LEU A CD2 1 
ATOM   1306 N N   . PHE A 1 191 ? 85.177 -1.345  35.417  1.00 41.07 ?  181 PHE A N   1 
ATOM   1307 C CA  . PHE A 1 191 ? 86.443 -1.733  34.818  1.00 46.18 ?  181 PHE A CA  1 
ATOM   1308 C C   . PHE A 1 191 ? 87.606 -1.547  35.785  1.00 48.48 ?  181 PHE A C   1 
ATOM   1309 O O   . PHE A 1 191 ? 88.605 -2.274  35.695  1.00 52.10 ?  181 PHE A O   1 
ATOM   1310 C CB  . PHE A 1 191 ? 86.643 -0.964  33.517  1.00 51.96 ?  181 PHE A CB  1 
ATOM   1311 C CG  . PHE A 1 191 ? 85.858 -1.541  32.383  1.00 53.90 ?  181 PHE A CG  1 
ATOM   1312 C CD1 . PHE A 1 191 ? 86.193 -2.786  31.862  1.00 57.78 ?  181 PHE A CD1 1 
ATOM   1313 C CD2 . PHE A 1 191 ? 84.749 -0.885  31.881  1.00 50.33 ?  181 PHE A CD2 1 
ATOM   1314 C CE1 . PHE A 1 191 ? 85.458 -3.347  30.829  1.00 51.95 ?  181 PHE A CE1 1 
ATOM   1315 C CE2 . PHE A 1 191 ? 84.012 -1.435  30.846  1.00 50.38 ?  181 PHE A CE2 1 
ATOM   1316 C CZ  . PHE A 1 191 ? 84.365 -2.667  30.320  1.00 52.39 ?  181 PHE A CZ  1 
ATOM   1317 N N   . GLU A 1 192 ? 87.484 -0.623  36.739  1.00 48.15 ?  182 GLU A N   1 
ATOM   1318 C CA  . GLU A 1 192 ? 88.495 -0.518  37.788  1.00 53.36 ?  182 GLU A CA  1 
ATOM   1319 C C   . GLU A 1 192 ? 88.540 -1.791  38.626  1.00 55.42 ?  182 GLU A C   1 
ATOM   1320 O O   . GLU A 1 192 ? 89.614 -2.368  38.846  1.00 45.54 ?  182 GLU A O   1 
ATOM   1321 C CB  . GLU A 1 192 ? 88.216 0.700   38.671  1.00 49.30 ?  182 GLU A CB  1 
ATOM   1322 C CG  . GLU A 1 192 ? 88.874 1.981   38.171  1.00 61.10 ?  182 GLU A CG  1 
ATOM   1323 C CD  . GLU A 1 192 ? 88.151 3.238   38.628  1.00 64.48 ?  182 GLU A CD  1 
ATOM   1324 O OE1 . GLU A 1 192 ? 87.472 3.192   39.678  1.00 73.17 ?  182 GLU A OE1 1 
ATOM   1325 O OE2 . GLU A 1 192 ? 88.260 4.276   37.936  1.00 70.95 -1 182 GLU A OE2 1 
ATOM   1326 N N   . LYS A 1 193 ? 87.372 -2.259  39.084  1.00 50.78 ?  183 LYS A N   1 
ATOM   1327 C CA  . LYS A 1 193 ? 87.328 -3.397  39.994  1.00 53.13 ?  183 LYS A CA  1 
ATOM   1328 C C   . LYS A 1 193 ? 87.561 -4.726  39.288  1.00 50.51 ?  183 LYS A C   1 
ATOM   1329 O O   . LYS A 1 193 ? 87.911 -5.711  39.950  1.00 46.95 ?  183 LYS A O   1 
ATOM   1330 C CB  . LYS A 1 193 ? 85.985 -3.431  40.726  1.00 51.34 ?  183 LYS A CB  1 
ATOM   1331 C CG  . LYS A 1 193 ? 85.692 -2.165  41.517  1.00 51.67 ?  183 LYS A CG  1 
ATOM   1332 C CD  . LYS A 1 193 ? 86.717 -1.933  42.624  1.00 55.63 ?  183 LYS A CD  1 
ATOM   1333 C CE  . LYS A 1 193 ? 86.380 -0.683  43.428  1.00 62.55 ?  183 LYS A CE  1 
ATOM   1334 N NZ  . LYS A 1 193 ? 87.390 -0.407  44.490  1.00 62.40 ?  183 LYS A NZ  1 
ATOM   1335 N N   . LEU A 1 194 ? 87.394 -4.769  37.962  1.00 45.07 ?  184 LEU A N   1 
ATOM   1336 C CA  . LEU A 1 194 ? 87.588 -6.010  37.213  1.00 44.96 ?  184 LEU A CA  1 
ATOM   1337 C C   . LEU A 1 194 ? 89.040 -6.476  37.285  1.00 57.19 ?  184 LEU A C   1 
ATOM   1338 O O   . LEU A 1 194 ? 89.312 -7.682  37.346  1.00 54.49 ?  184 LEU A O   1 
ATOM   1339 C CB  . LEU A 1 194 ? 87.148 -5.804  35.758  1.00 45.46 ?  184 LEU A CB  1 
ATOM   1340 C CG  . LEU A 1 194 ? 85.675 -6.102  35.413  1.00 57.57 ?  184 LEU A CG  1 
ATOM   1341 C CD1 . LEU A 1 194 ? 85.510 -6.251  33.914  1.00 55.30 ?  184 LEU A CD1 1 
ATOM   1342 C CD2 . LEU A 1 194 ? 85.150 -7.356  36.114  1.00 43.62 ?  184 LEU A CD2 1 
ATOM   1343 N N   . THR A 1 195 ? 89.987 -5.532  37.289  1.00 55.46 ?  185 THR A N   1 
ATOM   1344 C CA  . THR A 1 195 ? 91.403 -5.856  37.450  1.00 57.74 ?  185 THR A CA  1 
ATOM   1345 C C   . THR A 1 195 ? 91.733 -6.400  38.838  1.00 53.65 ?  185 THR A C   1 
ATOM   1346 O O   . THR A 1 195 ? 92.835 -6.920  39.036  1.00 58.04 ?  185 THR A O   1 
ATOM   1347 C CB  . THR A 1 195 ? 92.255 -4.611  37.180  1.00 58.41 ?  185 THR A CB  1 
ATOM   1348 O OG1 . THR A 1 195 ? 91.902 -3.582  38.115  1.00 60.22 ?  185 THR A OG1 1 
ATOM   1349 C CG2 . THR A 1 195 ? 92.028 -4.090  35.757  1.00 58.48 ?  185 THR A CG2 1 
ATOM   1350 N N   . GLN A 1 196 ? 90.819 -6.283  39.798  1.00 56.51 ?  186 GLN A N   1 
ATOM   1351 C CA  . GLN A 1 196 ? 91.046 -6.702  41.172  1.00 51.44 ?  186 GLN A CA  1 
ATOM   1352 C C   . GLN A 1 196 ? 90.374 -8.022  41.507  1.00 53.33 ?  186 GLN A C   1 
ATOM   1353 O O   . GLN A 1 196 ? 90.422 -8.450  42.663  1.00 55.15 ?  186 GLN A O   1 
ATOM   1354 C CB  . GLN A 1 196 ? 90.534 -5.631  42.129  1.00 53.35 ?  186 GLN A CB  1 
ATOM   1355 C CG  . GLN A 1 196 ? 91.374 -4.378  42.171  1.00 57.70 ?  186 GLN A CG  1 
ATOM   1356 C CD  . GLN A 1 196 ? 90.932 -3.457  43.282  1.00 62.05 ?  186 GLN A CD  1 
ATOM   1357 O OE1 . GLN A 1 196 ? 90.438 -2.355  43.032  1.00 59.59 ?  186 GLN A OE1 1 
ATOM   1358 N NE2 . GLN A 1 196 ? 91.093 -3.908  44.523  1.00 64.81 ?  186 GLN A NE2 1 
ATOM   1359 N N   . VAL A 1 197 ? 89.737 -8.665  40.547  1.00 53.66 ?  187 VAL A N   1 
ATOM   1360 C CA  . VAL A 1 197 ? 89.090 -9.945  40.795  1.00 56.82 ?  187 VAL A CA  1 
ATOM   1361 C C   . VAL A 1 197 ? 90.133 -11.045 40.637  1.00 51.01 ?  187 VAL A C   1 
ATOM   1362 O O   . VAL A 1 197 ? 90.963 -11.007 39.722  1.00 53.59 ?  187 VAL A O   1 
ATOM   1363 C CB  . VAL A 1 197 ? 87.896 -10.151 39.841  1.00 54.10 ?  187 VAL A CB  1 
ATOM   1364 C CG1 . VAL A 1 197 ? 87.368 -11.584 39.936  1.00 51.77 ?  187 VAL A CG1 1 
ATOM   1365 C CG2 . VAL A 1 197 ? 86.800 -9.138  40.128  1.00 46.67 ?  187 VAL A CG2 1 
ATOM   1366 N N   . LYS A 1 198 ? 90.103 -12.022 41.532  1.00 55.55 ?  188 LYS A N   1 
ATOM   1367 C CA  . LYS A 1 198 ? 91.017 -13.150 41.470  1.00 58.20 ?  188 LYS A CA  1 
ATOM   1368 C C   . LYS A 1 198 ? 90.251 -14.414 41.105  1.00 59.48 ?  188 LYS A C   1 
ATOM   1369 O O   . LYS A 1 198 ? 89.018 -14.465 41.171  1.00 54.09 ?  188 LYS A O   1 
ATOM   1370 C CB  . LYS A 1 198 ? 91.758 -13.321 42.805  1.00 60.17 ?  188 LYS A CB  1 
ATOM   1371 N N   . ASN A 1 199 ? 90.995 -15.446 40.714  1.00 59.79 ?  189 ASN A N   1 
ATOM   1372 C CA  . ASN A 1 199 ? 90.410 -16.742 40.383  1.00 62.41 ?  189 ASN A CA  1 
ATOM   1373 C C   . ASN A 1 199 ? 90.893 -17.827 41.343  1.00 63.68 ?  189 ASN A C   1 
ATOM   1374 O O   . ASN A 1 199 ? 91.188 -18.958 40.939  1.00 65.46 ?  189 ASN A O   1 
ATOM   1375 C CB  . ASN A 1 199 ? 90.691 -17.124 38.925  1.00 60.90 ?  189 ASN A CB  1 
ATOM   1376 C CG  . ASN A 1 199 ? 92.180 -17.158 38.579  1.00 62.34 ?  189 ASN A CG  1 
ATOM   1377 O OD1 . ASN A 1 199 ? 93.025 -16.595 39.283  1.00 66.31 ?  189 ASN A OD1 1 
ATOM   1378 N ND2 . ASN A 1 199 ? 92.497 -17.800 37.459  1.00 53.07 ?  189 ASN A ND2 1 
ATOM   1379 N N   . ASP A 1 200 ? 90.945 -17.494 42.638  1.00 60.35 ?  190 ASP A N   1 
ATOM   1380 C CA  . ASP A 1 200 ? 91.379 -18.414 43.690  1.00 59.83 ?  190 ASP A CA  1 
ATOM   1381 C C   . ASP A 1 200 ? 90.228 -19.350 44.069  1.00 67.52 ?  190 ASP A C   1 
ATOM   1382 O O   . ASP A 1 200 ? 89.669 -19.301 45.168  1.00 70.86 ?  190 ASP A O   1 
ATOM   1383 C CB  . ASP A 1 200 ? 91.883 -17.633 44.899  1.00 56.17 ?  190 ASP A CB  1 
ATOM   1384 N N   . ASN A 1 201 ? 89.873 -20.220 43.124  1.00 70.32 ?  191 ASN A N   1 
ATOM   1385 C CA  . ASN A 1 201 ? 88.785 -21.166 43.334  1.00 72.79 ?  191 ASN A CA  1 
ATOM   1386 C C   . ASN A 1 201 ? 89.083 -22.448 42.567  1.00 68.15 ?  191 ASN A C   1 
ATOM   1387 O O   . ASN A 1 201 ? 90.057 -22.538 41.815  1.00 66.74 ?  191 ASN A O   1 
ATOM   1388 C CB  . ASN A 1 201 ? 87.435 -20.577 42.904  1.00 68.59 ?  191 ASN A CB  1 
ATOM   1389 C CG  . ASN A 1 201 ? 87.500 -19.910 41.546  1.00 67.19 ?  191 ASN A CG  1 
ATOM   1390 O OD1 . ASN A 1 201 ? 87.648 -18.688 41.440  1.00 62.77 ?  191 ASN A OD1 1 
ATOM   1391 N ND2 . ASN A 1 201 ? 87.383 -20.712 40.492  1.00 73.50 ?  191 ASN A ND2 1 
ATOM   1392 N N   . ALA A 1 202 ? 88.212 -23.445 42.758  1.00 73.45 ?  192 ALA A N   1 
ATOM   1393 C CA  . ALA A 1 202 ? 88.412 -24.753 42.143  1.00 79.68 ?  192 ALA A CA  1 
ATOM   1394 C C   . ALA A 1 202 ? 88.231 -24.728 40.630  1.00 76.62 ?  192 ALA A C   1 
ATOM   1395 O O   . ALA A 1 202 ? 88.760 -25.607 39.941  1.00 81.22 ?  192 ALA A O   1 
ATOM   1396 C CB  . ALA A 1 202 ? 87.458 -25.779 42.760  1.00 77.60 ?  192 ALA A CB  1 
ATOM   1397 N N   . GLN A 1 203 ? 87.498 -23.752 40.099  1.00 77.16 ?  193 GLN A N   1 
ATOM   1398 C CA  . GLN A 1 203 ? 87.287 -23.651 38.663  1.00 70.24 ?  193 GLN A CA  1 
ATOM   1399 C C   . GLN A 1 203 ? 88.366 -22.837 37.956  1.00 65.68 ?  193 GLN A C   1 
ATOM   1400 O O   . GLN A 1 203 ? 88.469 -22.907 36.726  1.00 63.46 ?  193 GLN A O   1 
ATOM   1401 C CB  . GLN A 1 203 ? 85.908 -23.040 38.382  1.00 64.87 ?  193 GLN A CB  1 
ATOM   1402 N N   . GLY A 1 204 ? 89.177 -22.084 38.696  1.00 63.39 ?  194 GLY A N   1 
ATOM   1403 C CA  . GLY A 1 204 ? 90.115 -21.173 38.073  1.00 56.11 ?  194 GLY A CA  1 
ATOM   1404 C C   . GLY A 1 204 ? 89.480 -19.990 37.377  1.00 58.60 ?  194 GLY A C   1 
ATOM   1405 O O   . GLY A 1 204 ? 90.135 -19.345 36.551  1.00 58.55 ?  194 GLY A O   1 
ATOM   1406 N N   . GLU A 1 205 ? 88.226 -19.672 37.695  1.00 61.79 ?  195 GLU A N   1 
ATOM   1407 C CA  . GLU A 1 205 ? 87.487 -18.639 36.979  1.00 61.99 ?  195 GLU A CA  1 
ATOM   1408 C C   . GLU A 1 205 ? 87.377 -17.342 37.775  1.00 55.46 ?  195 GLU A C   1 
ATOM   1409 O O   . GLU A 1 205 ? 87.397 -17.332 39.009  1.00 54.53 ?  195 GLU A O   1 
ATOM   1410 C CB  . GLU A 1 205 ? 86.079 -19.116 36.621  1.00 60.24 ?  195 GLU A CB  1 
ATOM   1411 C CG  . GLU A 1 205 ? 86.023 -20.403 35.825  1.00 66.79 ?  195 GLU A CG  1 
ATOM   1412 C CD  . GLU A 1 205 ? 84.604 -20.749 35.405  1.00 70.64 ?  195 GLU A CD  1 
ATOM   1413 O OE1 . GLU A 1 205 ? 83.660 -20.347 36.125  1.00 68.32 ?  195 GLU A OE1 1 
ATOM   1414 O OE2 . GLU A 1 205 ? 84.436 -21.430 34.368  1.00 65.72 ?  195 GLU A OE2 1 
ATOM   1415 N N   . TYR A 1 206 ? 87.240 -16.243 37.038  1.00 53.22 ?  196 TYR A N   1 
ATOM   1416 C CA  . TYR A 1 206 ? 86.972 -14.922 37.599  1.00 57.63 ?  196 TYR A CA  1 
ATOM   1417 C C   . TYR A 1 206 ? 85.467 -14.680 37.539  1.00 51.13 ?  196 TYR A C   1 
ATOM   1418 O O   . TYR A 1 206 ? 84.899 -14.568 36.449  1.00 44.57 ?  196 TYR A O   1 
ATOM   1419 C CB  . TYR A 1 206 ? 87.711 -13.837 36.821  1.00 47.87 ?  196 TYR A CB  1 
ATOM   1420 C CG  . TYR A 1 206 ? 89.201 -14.002 36.772  1.00 50.40 ?  196 TYR A CG  1 
ATOM   1421 C CD1 . TYR A 1 206 ? 89.803 -14.743 35.770  1.00 51.94 ?  196 TYR A CD1 1 
ATOM   1422 C CD2 . TYR A 1 206 ? 90.012 -13.383 37.713  1.00 59.01 ?  196 TYR A CD2 1 
ATOM   1423 C CE1 . TYR A 1 206 ? 91.176 -14.880 35.715  1.00 63.39 ?  196 TYR A CE1 1 
ATOM   1424 C CE2 . TYR A 1 206 ? 91.383 -13.507 37.668  1.00 57.36 ?  196 TYR A CE2 1 
ATOM   1425 C CZ  . TYR A 1 206 ? 91.963 -14.256 36.671  1.00 64.12 ?  196 TYR A CZ  1 
ATOM   1426 O OH  . TYR A 1 206 ? 93.336 -14.381 36.638  1.00 58.12 ?  196 TYR A OH  1 
ATOM   1427 N N   . TYR A 1 207 ? 84.830 -14.579 38.703  1.00 50.95 ?  197 TYR A N   1 
ATOM   1428 C CA  . TYR A 1 207 ? 83.379 -14.458 38.792  1.00 52.34 ?  197 TYR A CA  1 
ATOM   1429 C C   . TYR A 1 207 ? 82.973 -12.999 38.960  1.00 52.10 ?  197 TYR A C   1 
ATOM   1430 O O   . TYR A 1 207 ? 83.477 -12.301 39.849  1.00 45.42 ?  197 TYR A O   1 
ATOM   1431 C CB  . TYR A 1 207 ? 82.827 -15.309 39.939  1.00 50.58 ?  197 TYR A CB  1 
ATOM   1432 C CG  . TYR A 1 207 ? 82.922 -16.804 39.689  1.00 63.70 ?  197 TYR A CG  1 
ATOM   1433 C CD1 . TYR A 1 207 ? 81.868 -17.495 39.096  1.00 67.00 ?  197 TYR A CD1 1 
ATOM   1434 C CD2 . TYR A 1 207 ? 84.065 -17.525 40.033  1.00 62.43 ?  197 TYR A CD2 1 
ATOM   1435 C CE1 . TYR A 1 207 ? 81.943 -18.866 38.861  1.00 61.46 ?  197 TYR A CE1 1 
ATOM   1436 C CE2 . TYR A 1 207 ? 84.148 -18.895 39.803  1.00 62.90 ?  197 TYR A CE2 1 
ATOM   1437 C CZ  . TYR A 1 207 ? 83.084 -19.556 39.216  1.00 63.74 ?  197 TYR A CZ  1 
ATOM   1438 O OH  . TYR A 1 207 ? 83.160 -20.909 38.977  1.00 68.72 ?  197 TYR A OH  1 
ATOM   1439 N N   . LEU A 1 208 ? 82.051 -12.553 38.101  1.00 47.94 ?  198 LEU A N   1 
ATOM   1440 C CA  . LEU A 1 208 ? 81.593 -11.165 38.134  1.00 47.71 ?  198 LEU A CA  1 
ATOM   1441 C C   . LEU A 1 208 ? 81.000 -10.698 39.460  1.00 47.03 ?  198 LEU A C   1 
ATOM   1442 O O   . LEU A 1 208 ? 81.284 -9.549  39.847  1.00 47.16 ?  198 LEU A O   1 
ATOM   1443 C CB  . LEU A 1 208 ? 80.598 -10.927 36.992  1.00 45.37 ?  198 LEU A CB  1 
ATOM   1444 C CG  . LEU A 1 208 ? 80.352 -9.438  36.758  1.00 46.01 ?  198 LEU A CG  1 
ATOM   1445 C CD1 . LEU A 1 208 ? 81.414 -8.813  35.865  1.00 47.17 ?  198 LEU A CD1 1 
ATOM   1446 C CD2 . LEU A 1 208 ? 78.975 -9.283  36.114  1.00 49.16 ?  198 LEU A CD2 1 
ATOM   1447 N N   . PRO A 1 209 ? 80.169 -11.469 40.177  1.00 50.91 ?  199 PRO A N   1 
ATOM   1448 C CA  . PRO A 1 209 ? 79.661 -10.963 41.469  1.00 45.81 ?  199 PRO A CA  1 
ATOM   1449 C C   . PRO A 1 209 ? 80.760 -10.549 42.436  1.00 47.76 ?  199 PRO A C   1 
ATOM   1450 O O   . PRO A 1 209 ? 80.490 -9.771  43.358  1.00 51.81 ?  199 PRO A O   1 
ATOM   1451 C CB  . PRO A 1 209 ? 78.845 -12.146 42.016  1.00 46.77 ?  199 PRO A CB  1 
ATOM   1452 C CG  . PRO A 1 209 ? 78.378 -12.855 40.797  1.00 54.26 ?  199 PRO A CG  1 
ATOM   1453 C CD  . PRO A 1 209 ? 79.524 -12.747 39.813  1.00 48.75 ?  199 PRO A CD  1 
ATOM   1454 N N   . ASP A 1 210 ? 81.989 -11.033 42.251  1.00 45.58 ?  200 ASP A N   1 
ATOM   1455 C CA  . ASP A 1 210 ? 83.098 -10.581 43.086  1.00 51.10 ?  200 ASP A CA  1 
ATOM   1456 C C   . ASP A 1 210 ? 83.274 -9.066  43.024  1.00 54.04 ?  200 ASP A C   1 
ATOM   1457 O O   . ASP A 1 210 ? 83.642 -8.445  44.029  1.00 52.25 ?  200 ASP A O   1 
ATOM   1458 C CB  . ASP A 1 210 ? 84.384 -11.288 42.662  1.00 50.11 ?  200 ASP A CB  1 
ATOM   1459 C CG  . ASP A 1 210 ? 84.558 -12.649 43.324  1.00 56.18 ?  200 ASP A CG  1 
ATOM   1460 O OD1 . ASP A 1 210 ? 83.549 -13.343 43.582  1.00 55.83 ?  200 ASP A OD1 1 
ATOM   1461 O OD2 . ASP A 1 210 ? 85.718 -13.043 43.558  1.00 65.73 -1 200 ASP A OD2 1 
ATOM   1462 N N   . VAL A 1 211 ? 83.011 -8.455  41.860  1.00 50.17 ?  201 VAL A N   1 
ATOM   1463 C CA  . VAL A 1 211 ? 83.067 -6.998  41.737  1.00 46.82 ?  201 VAL A CA  1 
ATOM   1464 C C   . VAL A 1 211 ? 82.203 -6.338  42.805  1.00 53.73 ?  201 VAL A C   1 
ATOM   1465 O O   . VAL A 1 211 ? 82.577 -5.312  43.387  1.00 51.48 ?  201 VAL A O   1 
ATOM   1466 C CB  . VAL A 1 211 ? 82.628 -6.566  40.324  1.00 49.86 ?  201 VAL A CB  1 
ATOM   1467 C CG1 . VAL A 1 211 ? 82.262 -5.085  40.297  1.00 45.15 ?  201 VAL A CG1 1 
ATOM   1468 C CG2 . VAL A 1 211 ? 83.697 -6.882  39.320  1.00 47.95 ?  201 VAL A CG2 1 
ATOM   1469 N N   . LEU A 1 212 ? 81.037 -6.921  43.082  1.00 45.93 ?  202 LEU A N   1 
ATOM   1470 C CA  . LEU A 1 212 ? 80.118 -6.328  44.045  1.00 48.87 ?  202 LEU A CA  1 
ATOM   1471 C C   . LEU A 1 212 ? 80.738 -6.298  45.435  1.00 49.72 ?  202 LEU A C   1 
ATOM   1472 O O   . LEU A 1 212 ? 80.662 -5.290  46.145  1.00 45.33 ?  202 LEU A O   1 
ATOM   1473 C CB  . LEU A 1 212 ? 78.819 -7.124  44.066  1.00 49.62 ?  202 LEU A CB  1 
ATOM   1474 C CG  . LEU A 1 212 ? 77.975 -7.051  42.799  1.00 50.95 ?  202 LEU A CG  1 
ATOM   1475 C CD1 . LEU A 1 212 ? 76.847 -8.066  42.908  1.00 55.47 ?  202 LEU A CD1 1 
ATOM   1476 C CD2 . LEU A 1 212 ? 77.438 -5.663  42.590  1.00 50.44 ?  202 LEU A CD2 1 
ATOM   1477 N N   . SER A 1 213 ? 81.332 -7.415  45.856  1.00 49.15 ?  203 SER A N   1 
ATOM   1478 C CA  . SER A 1 213 ? 81.952 -7.440  47.174  1.00 60.36 ?  203 SER A CA  1 
ATOM   1479 C C   . SER A 1 213 ? 83.087 -6.431  47.255  1.00 56.73 ?  203 SER A C   1 
ATOM   1480 O O   . SER A 1 213 ? 83.292 -5.811  48.306  1.00 55.73 ?  203 SER A O   1 
ATOM   1481 C CB  . SER A 1 213 ? 82.430 -8.857  47.497  1.00 60.76 ?  203 SER A CB  1 
ATOM   1482 O OG  . SER A 1 213 ? 83.503 -9.239  46.658  1.00 71.99 ?  203 SER A OG  1 
ATOM   1483 N N   . LEU A 1 214 ? 83.783 -6.208  46.136  1.00 50.17 ?  204 LEU A N   1 
ATOM   1484 C CA  . LEU A 1 214 ? 84.867 -5.231  46.087  1.00 52.68 ?  204 LEU A CA  1 
ATOM   1485 C C   . LEU A 1 214 ? 84.345 -3.815  46.324  1.00 58.23 ?  204 LEU A C   1 
ATOM   1486 O O   . LEU A 1 214 ? 84.933 -3.042  47.089  1.00 55.28 ?  204 LEU A O   1 
ATOM   1487 C CB  . LEU A 1 214 ? 85.565 -5.338  44.733  1.00 55.64 ?  204 LEU A CB  1 
ATOM   1488 C CG  . LEU A 1 214 ? 86.723 -6.330  44.662  1.00 56.53 ?  204 LEU A CG  1 
ATOM   1489 C CD1 . LEU A 1 214 ? 87.232 -6.451  43.228  1.00 53.10 ?  204 LEU A CD1 1 
ATOM   1490 C CD2 . LEU A 1 214 ? 87.841 -5.900  45.606  1.00 56.29 ?  204 LEU A CD2 1 
ATOM   1491 N N   . ILE A 1 215 ? 83.244 -3.454  45.661  1.00 48.36 ?  205 ILE A N   1 
ATOM   1492 C CA  . ILE A 1 215 ? 82.602 -2.162  45.903  1.00 49.38 ?  205 ILE A CA  1 
ATOM   1493 C C   . ILE A 1 215 ? 82.124 -2.049  47.344  1.00 53.31 ?  205 ILE A C   1 
ATOM   1494 O O   . ILE A 1 215 ? 82.284 -1.001  47.987  1.00 50.23 ?  205 ILE A O   1 
ATOM   1495 C CB  . ILE A 1 215 ? 81.448 -1.951  44.904  1.00 45.49 ?  205 ILE A CB  1 
ATOM   1496 C CG1 . ILE A 1 215 ? 81.920 -2.270  43.480  1.00 52.06 ?  205 ILE A CG1 1 
ATOM   1497 C CG2 . ILE A 1 215 ? 80.838 -0.562  45.064  1.00 44.60 ?  205 ILE A CG2 1 
ATOM   1498 C CD1 . ILE A 1 215 ? 80.979 -1.813  42.390  1.00 51.24 ?  205 ILE A CD1 1 
ATOM   1499 N N   . LEU A 1 216 ? 81.524 -3.118  47.872  1.00 52.93 ?  206 LEU A N   1 
ATOM   1500 C CA  . LEU A 1 216 ? 81.058 -3.101  49.256  1.00 56.35 ?  206 LEU A CA  1 
ATOM   1501 C C   . LEU A 1 216 ? 82.207 -2.862  50.228  1.00 56.44 ?  206 LEU A C   1 
ATOM   1502 O O   . LEU A 1 216 ? 82.121 -1.992  51.104  1.00 58.61 ?  206 LEU A O   1 
ATOM   1503 C CB  . LEU A 1 216 ? 80.333 -4.407  49.588  1.00 57.35 ?  206 LEU A CB  1 
ATOM   1504 C CG  . LEU A 1 216 ? 79.017 -4.609  48.842  1.00 52.93 ?  206 LEU A CG  1 
ATOM   1505 C CD1 . LEU A 1 216 ? 78.393 -5.957  49.173  1.00 50.66 ?  206 LEU A CD1 1 
ATOM   1506 C CD2 . LEU A 1 216 ? 78.088 -3.467  49.205  1.00 50.67 ?  206 LEU A CD2 1 
ATOM   1507 N N   . ASN A 1 217 ? 83.300 -3.616  50.083  1.00 60.15 ?  207 ASN A N   1 
ATOM   1508 C CA  . ASN A 1 217 ? 84.457 -3.411  50.953  1.00 62.82 ?  207 ASN A CA  1 
ATOM   1509 C C   . ASN A 1 217 ? 85.134 -2.067  50.742  1.00 63.90 ?  207 ASN A C   1 
ATOM   1510 O O   . ASN A 1 217 ? 86.153 -1.807  51.389  1.00 79.94 ?  207 ASN A O   1 
ATOM   1511 C CB  . ASN A 1 217 ? 85.495 -4.521  50.765  1.00 60.51 ?  207 ASN A CB  1 
ATOM   1512 C CG  . ASN A 1 217 ? 84.931 -5.890  51.017  1.00 59.31 ?  207 ASN A CG  1 
ATOM   1513 O OD1 . ASN A 1 217 ? 83.995 -6.053  51.801  1.00 75.87 ?  207 ASN A OD1 1 
ATOM   1514 N ND2 . ASN A 1 217 ? 85.531 -6.898  50.397  1.00 59.44 ?  207 ASN A ND2 1 
ATOM   1515 N N   . ASP A 1 218 ? 84.611 -1.220  49.859  1.00 64.69 ?  208 ASP A N   1 
ATOM   1516 C CA  . ASP A 1 218 ? 85.151 0.112   49.624  1.00 63.82 ?  208 ASP A CA  1 
ATOM   1517 C C   . ASP A 1 218 ? 84.190 1.207   50.069  1.00 64.48 ?  208 ASP A C   1 
ATOM   1518 O O   . ASP A 1 218 ? 84.480 2.392   49.875  1.00 66.61 ?  208 ASP A O   1 
ATOM   1519 C CB  . ASP A 1 218 ? 85.499 0.278   48.145  1.00 64.72 ?  208 ASP A CB  1 
ATOM   1520 C CG  . ASP A 1 218 ? 86.983 0.197   47.889  1.00 68.14 ?  208 ASP A CG  1 
ATOM   1521 O OD1 . ASP A 1 218 ? 87.707 -0.333  48.760  1.00 79.92 ?  208 ASP A OD1 1 
ATOM   1522 O OD2 . ASP A 1 218 ? 87.421 0.647   46.812  1.00 72.33 ?  208 ASP A OD2 1 
ATOM   1523 N N   . GLY A 1 219 ? 83.059 0.837   50.667  1.00 63.12 ?  209 GLY A N   1 
ATOM   1524 C CA  . GLY A 1 219 ? 82.069 1.800   51.100  1.00 65.87 ?  209 GLY A CA  1 
ATOM   1525 C C   . GLY A 1 219 ? 81.171 2.339   50.010  1.00 57.87 ?  209 GLY A C   1 
ATOM   1526 O O   . GLY A 1 219 ? 80.487 3.344   50.237  1.00 55.44 ?  209 GLY A O   1 
ATOM   1527 N N   . GLY A 1 220 ? 81.153 1.709   48.832  1.00 59.51 ?  210 GLY A N   1 
ATOM   1528 C CA  . GLY A 1 220 ? 80.284 2.156   47.765  1.00 51.46 ?  210 GLY A CA  1 
ATOM   1529 C C   . GLY A 1 220 ? 78.877 1.592   47.882  1.00 51.87 ?  210 GLY A C   1 
ATOM   1530 O O   . GLY A 1 220 ? 78.630 0.595   48.559  1.00 54.44 ?  210 GLY A O   1 
ATOM   1531 N N   . ILE A 1 221 ? 77.945 2.266   47.212  1.00 48.02 ?  211 ILE A N   1 
ATOM   1532 C CA  . ILE A 1 221 ? 76.532 1.906   47.271  1.00 47.82 ?  211 ILE A CA  1 
ATOM   1533 C C   . ILE A 1 221 ? 76.266 0.767   46.299  1.00 50.17 ?  211 ILE A C   1 
ATOM   1534 O O   . ILE A 1 221 ? 76.622 0.848   45.113  1.00 42.59 ?  211 ILE A O   1 
ATOM   1535 C CB  . ILE A 1 221 ? 75.644 3.123   46.953  1.00 53.08 ?  211 ILE A CB  1 
ATOM   1536 C CG1 . ILE A 1 221 ? 75.770 4.198   48.042  1.00 59.54 ?  211 ILE A CG1 1 
ATOM   1537 C CG2 . ILE A 1 221 ? 74.187 2.708   46.752  1.00 53.28 ?  211 ILE A CG2 1 
ATOM   1538 C CD1 . ILE A 1 221 ? 75.411 5.603   47.563  1.00 48.22 ?  211 ILE A CD1 1 
ATOM   1539 N N   . VAL A 1 222 ? 75.668 -0.312  46.801  1.00 42.17 ?  212 VAL A N   1 
ATOM   1540 C CA  . VAL A 1 222 ? 75.195 -1.404  45.953  1.00 46.68 ?  212 VAL A CA  1 
ATOM   1541 C C   . VAL A 1 222 ? 73.720 -1.635  46.243  1.00 47.53 ?  212 VAL A C   1 
ATOM   1542 O O   . VAL A 1 222 ? 73.347 -2.054  47.348  1.00 46.56 ?  212 VAL A O   1 
ATOM   1543 C CB  . VAL A 1 222 ? 75.998 -2.695  46.134  1.00 48.51 ?  212 VAL A CB  1 
ATOM   1544 C CG1 . VAL A 1 222 ? 75.471 -3.753  45.157  1.00 42.95 ?  212 VAL A CG1 1 
ATOM   1545 C CG2 . VAL A 1 222 ? 77.486 -2.439  45.875  1.00 46.34 ?  212 VAL A CG2 1 
ATOM   1546 N N   . GLU A 1 223 ? 72.889 -1.378  45.242  1.00 43.26 ?  213 GLU A N   1 
ATOM   1547 C CA  . GLU A 1 223 ? 71.442 -1.459  45.331  1.00 38.58 ?  213 GLU A CA  1 
ATOM   1548 C C   . GLU A 1 223 ? 70.950 -2.836  44.886  1.00 36.19 ?  213 GLU A C   1 
ATOM   1549 O O   . GLU A 1 223 ? 71.670 -3.610  44.252  1.00 36.86 ?  213 GLU A O   1 
ATOM   1550 C CB  . GLU A 1 223 ? 70.808 -0.376  44.454  1.00 46.49 ?  213 GLU A CB  1 
ATOM   1551 C CG  . GLU A 1 223 ? 70.851 1.040   45.010  1.00 44.60 ?  213 GLU A CG  1 
ATOM   1552 C CD  . GLU A 1 223 ? 69.953 1.230   46.228  1.00 56.30 ?  213 GLU A CD  1 
ATOM   1553 O OE1 . GLU A 1 223 ? 68.891 0.576   46.290  1.00 55.76 ?  213 GLU A OE1 1 
ATOM   1554 O OE2 . GLU A 1 223 ? 70.284 2.070   47.097  1.00 64.34 ?  213 GLU A OE2 1 
ATOM   1555 N N   . VAL A 1 224 ? 69.707 -3.138  45.237  1.00 38.74 ?  214 VAL A N   1 
ATOM   1556 C CA  . VAL A 1 224 ? 69.032 -4.335  44.758  1.00 43.50 ?  214 VAL A CA  1 
ATOM   1557 C C   . VAL A 1 224 ? 67.687 -3.888  44.206  1.00 50.65 ?  214 VAL A C   1 
ATOM   1558 O O   . VAL A 1 224 ? 66.918 -3.220  44.910  1.00 43.29 ?  214 VAL A O   1 
ATOM   1559 C CB  . VAL A 1 224 ? 68.838 -5.387  45.868  1.00 45.07 ?  214 VAL A CB  1 
ATOM   1560 C CG1 . VAL A 1 224 ? 68.124 -6.622  45.319  1.00 42.09 ?  214 VAL A CG1 1 
ATOM   1561 C CG2 . VAL A 1 224 ? 70.166 -5.756  46.505  1.00 43.54 ?  214 VAL A CG2 1 
ATOM   1562 N N   . TYR A 1 225 ? 67.412 -4.231  42.951  1.00 40.22 ?  215 TYR A N   1 
ATOM   1563 C CA  . TYR A 1 225 ? 66.096 -4.021  42.360  1.00 42.84 ?  215 TYR A CA  1 
ATOM   1564 C C   . TYR A 1 225 ? 65.468 -5.377  42.069  1.00 43.70 ?  215 TYR A C   1 
ATOM   1565 O O   . TYR A 1 225 ? 66.089 -6.225  41.419  1.00 44.35 ?  215 TYR A O   1 
ATOM   1566 C CB  . TYR A 1 225 ? 66.180 -3.188  41.077  1.00 46.67 ?  215 TYR A CB  1 
ATOM   1567 C CG  . TYR A 1 225 ? 64.846 -3.105  40.395  1.00 48.80 ?  215 TYR A CG  1 
ATOM   1568 C CD1 . TYR A 1 225 ? 63.752 -2.545  41.047  1.00 56.35 ?  215 TYR A CD1 1 
ATOM   1569 C CD2 . TYR A 1 225 ? 64.653 -3.648  39.130  1.00 48.59 ?  215 TYR A CD2 1 
ATOM   1570 C CE1 . TYR A 1 225 ? 62.511 -2.489  40.445  1.00 47.90 ?  215 TYR A CE1 1 
ATOM   1571 C CE2 . TYR A 1 225 ? 63.401 -3.600  38.514  1.00 47.37 ?  215 TYR A CE2 1 
ATOM   1572 C CZ  . TYR A 1 225 ? 62.335 -3.020  39.184  1.00 54.14 ?  215 TYR A CZ  1 
ATOM   1573 O OH  . TYR A 1 225 ? 61.081 -2.952  38.601  1.00 59.25 ?  215 TYR A OH  1 
ATOM   1574 N N   . ARG A 1 226 ? 64.242 -5.580  42.551  1.00 40.50 ?  216 ARG A N   1 
ATOM   1575 C CA  . ARG A 1 226 ? 63.550 -6.857  42.429  1.00 45.71 ?  216 ARG A CA  1 
ATOM   1576 C C   . ARG A 1 226 ? 62.452 -6.753  41.383  1.00 47.18 ?  216 ARG A C   1 
ATOM   1577 O O   . ARG A 1 226 ? 61.574 -5.890  41.487  1.00 44.79 ?  216 ARG A O   1 
ATOM   1578 C CB  . ARG A 1 226 ? 62.931 -7.288  43.759  1.00 43.10 ?  216 ARG A CB  1 
ATOM   1579 C CG  . ARG A 1 226 ? 62.388 -8.697  43.719  1.00 48.92 ?  216 ARG A CG  1 
ATOM   1580 C CD  . ARG A 1 226 ? 61.746 -9.110  45.040  1.00 58.16 ?  216 ARG A CD  1 
ATOM   1581 N NE  . ARG A 1 226 ? 60.382 -8.613  45.156  1.00 67.99 ?  216 ARG A NE  1 
ATOM   1582 C CZ  . ARG A 1 226 ? 59.337 -9.166  44.553  1.00 62.87 ?  216 ARG A CZ  1 
ATOM   1583 N NH1 . ARG A 1 226 ? 59.468 -10.240 43.787  1.00 67.43 ?  216 ARG A NH1 1 
ATOM   1584 N NH2 . ARG A 1 226 ? 58.130 -8.629  44.718  1.00 65.35 ?  216 ARG A NH2 1 
ATOM   1585 N N   . THR A 1 227 ? 62.495 -7.629  40.384  1.00 41.30 ?  217 THR A N   1 
ATOM   1586 C CA  . THR A 1 227 ? 61.406 -7.722  39.425  1.00 40.77 ?  217 THR A CA  1 
ATOM   1587 C C   . THR A 1 227 ? 60.335 -8.658  39.962  1.00 44.47 ?  217 THR A C   1 
ATOM   1588 O O   . THR A 1 227 ? 60.642 -9.676  40.587  1.00 43.11 ?  217 THR A O   1 
ATOM   1589 C CB  . THR A 1 227 ? 61.890 -8.209  38.056  1.00 45.24 ?  217 THR A CB  1 
ATOM   1590 O OG1 . THR A 1 227 ? 60.772 -8.252  37.161  1.00 42.69 ?  217 THR A OG1 1 
ATOM   1591 C CG2 . THR A 1 227 ? 62.535 -9.606  38.138  1.00 39.60 ?  217 THR A CG2 1 
ATOM   1592 N N   . ASN A 1 228 ? 59.072 -8.299  39.728  1.00 43.90 ?  218 ASN A N   1 
ATOM   1593 C CA  . ASN A 1 228 ? 57.972 -9.155  40.153  1.00 51.63 ?  218 ASN A CA  1 
ATOM   1594 C C   . ASN A 1 228 ? 57.737 -10.331 39.211  1.00 55.17 ?  218 ASN A C   1 
ATOM   1595 O O   . ASN A 1 228 ? 56.937 -11.212 39.541  1.00 50.00 ?  218 ASN A O   1 
ATOM   1596 C CB  . ASN A 1 228 ? 56.681 -8.334  40.289  1.00 50.62 ?  218 ASN A CB  1 
ATOM   1597 N N   . ASP A 1 229 ? 58.417 -10.376 38.063  1.00 48.53 ?  219 ASP A N   1 
ATOM   1598 C CA  . ASP A 1 229 ? 58.239 -11.438 37.069  1.00 47.90 ?  219 ASP A CA  1 
ATOM   1599 C C   . ASP A 1 229 ? 59.502 -12.293 37.010  1.00 47.01 ?  219 ASP A C   1 
ATOM   1600 O O   . ASP A 1 229 ? 60.440 -11.989 36.269  1.00 49.43 ?  219 ASP A O   1 
ATOM   1601 C CB  . ASP A 1 229 ? 57.912 -10.847 35.707  1.00 50.27 ?  219 ASP A CB  1 
ATOM   1602 C CG  . ASP A 1 229 ? 57.651 -11.914 34.656  1.00 56.58 ?  219 ASP A CG  1 
ATOM   1603 O OD1 . ASP A 1 229 ? 57.820 -11.606 33.456  1.00 63.68 -1 219 ASP A OD1 1 
ATOM   1604 O OD2 . ASP A 1 229 ? 57.302 -13.062 35.029  1.00 54.94 ?  219 ASP A OD2 1 
ATOM   1605 N N   . VAL A 1 230 ? 59.510 -13.392 37.771  1.00 47.51 ?  220 VAL A N   1 
ATOM   1606 C CA  . VAL A 1 230 ? 60.691 -14.245 37.790  1.00 40.04 ?  220 VAL A CA  1 
ATOM   1607 C C   . VAL A 1 230 ? 60.826 -15.033 36.491  1.00 44.25 ?  220 VAL A C   1 
ATOM   1608 O O   . VAL A 1 230 ? 61.926 -15.484 36.156  1.00 41.95 ?  220 VAL A O   1 
ATOM   1609 C CB  . VAL A 1 230 ? 60.669 -15.178 39.018  1.00 47.84 ?  220 VAL A CB  1 
ATOM   1610 C CG1 . VAL A 1 230 ? 59.576 -16.219 38.895  1.00 47.91 ?  220 VAL A CG1 1 
ATOM   1611 C CG2 . VAL A 1 230 ? 62.037 -15.836 39.223  1.00 55.90 ?  220 VAL A CG2 1 
ATOM   1612 N N   . GLU A 1 231 ? 59.736 -15.192 35.735  1.00 41.19 ?  221 GLU A N   1 
ATOM   1613 C CA  . GLU A 1 231 ? 59.830 -15.841 34.428  1.00 42.06 ?  221 GLU A CA  1 
ATOM   1614 C C   . GLU A 1 231 ? 60.809 -15.116 33.516  1.00 43.87 ?  221 GLU A C   1 
ATOM   1615 O O   . GLU A 1 231 ? 61.518 -15.746 32.720  1.00 41.80 ?  221 GLU A O   1 
ATOM   1616 C CB  . GLU A 1 231 ? 58.453 -15.880 33.764  1.00 47.61 ?  221 GLU A CB  1 
ATOM   1617 C CG  . GLU A 1 231 ? 58.213 -17.074 32.885  1.00 54.87 ?  221 GLU A CG  1 
ATOM   1618 C CD  . GLU A 1 231 ? 56.804 -17.078 32.320  1.00 58.18 ?  221 GLU A CD  1 
ATOM   1619 O OE1 . GLU A 1 231 ? 56.347 -16.004 31.868  1.00 52.58 ?  221 GLU A OE1 1 
ATOM   1620 O OE2 . GLU A 1 231 ? 56.149 -18.137 32.364  1.00 57.46 ?  221 GLU A OE2 1 
ATOM   1621 N N   . GLU A 1 232 ? 60.853 -13.785 33.607  1.00 38.31 ?  222 GLU A N   1 
ATOM   1622 C CA  . GLU A 1 232 ? 61.584 -13.009 32.618  1.00 37.42 ?  222 GLU A CA  1 
ATOM   1623 C C   . GLU A 1 232 ? 63.096 -13.192 32.726  1.00 42.71 ?  222 GLU A C   1 
ATOM   1624 O O   . GLU A 1 232 ? 63.804 -12.933 31.744  1.00 35.79 ?  222 GLU A O   1 
ATOM   1625 C CB  . GLU A 1 232 ? 61.184 -11.528 32.712  1.00 42.19 ?  222 GLU A CB  1 
ATOM   1626 C CG  . GLU A 1 232 ? 62.114 -10.628 33.528  1.00 49.46 ?  222 GLU A CG  1 
ATOM   1627 C CD  . GLU A 1 232 ? 61.668 -9.163  33.527  1.00 47.33 ?  222 GLU A CD  1 
ATOM   1628 O OE1 . GLU A 1 232 ? 61.829 -8.505  32.478  1.00 43.97 ?  222 GLU A OE1 1 
ATOM   1629 O OE2 . GLU A 1 232 ? 61.173 -8.658  34.568  1.00 42.35 -1 222 GLU A OE2 1 
ATOM   1630 N N   . ILE A 1 233 ? 63.610 -13.674 33.860  1.00 37.77 ?  223 ILE A N   1 
ATOM   1631 C CA  . ILE A 1 233 ? 65.051 -13.846 34.022  1.00 42.05 ?  223 ILE A CA  1 
ATOM   1632 C C   . ILE A 1 233 ? 65.493 -15.267 33.698  1.00 43.07 ?  223 ILE A C   1 
ATOM   1633 O O   . ILE A 1 233 ? 66.652 -15.616 33.942  1.00 37.72 ?  223 ILE A O   1 
ATOM   1634 C CB  . ILE A 1 233 ? 65.507 -13.453 35.433  1.00 41.36 ?  223 ILE A CB  1 
ATOM   1635 C CG1 . ILE A 1 233 ? 64.979 -14.468 36.451  1.00 47.10 ?  223 ILE A CG1 1 
ATOM   1636 C CG2 . ILE A 1 233 ? 65.005 -12.047 35.770  1.00 43.43 ?  223 ILE A CG2 1 
ATOM   1637 C CD1 . ILE A 1 233 ? 65.507 -14.274 37.860  1.00 38.62 ?  223 ILE A CD1 1 
ATOM   1638 N N   . MET A 1 234 ? 64.581 -16.099 33.185  1.00 42.13 ?  224 MET A N   1 
ATOM   1639 C CA  . MET A 1 234 ? 64.872 -17.463 32.749  1.00 43.60 ?  224 MET A CA  1 
ATOM   1640 C C   . MET A 1 234 ? 66.131 -17.550 31.899  1.00 43.56 ?  224 MET A C   1 
ATOM   1641 O O   . MET A 1 234 ? 66.278 -16.827 30.910  1.00 37.49 ?  224 MET A O   1 
ATOM   1642 C CB  . MET A 1 234 ? 63.666 -18.003 31.960  1.00 46.34 ?  224 MET A CB  1 
ATOM   1643 C CG  . MET A 1 234 ? 63.713 -19.508 31.658  1.00 53.22 ?  224 MET A CG  1 
ATOM   1644 S SD  . MET A 1 234 ? 62.646 -19.964 30.252  1.00 53.18 ?  224 MET A SD  1 
ATOM   1645 C CE  . MET A 1 234 ? 61.024 -19.457 30.853  1.00 48.05 ?  224 MET A CE  1 
ATOM   1646 N N   . GLY A 1 235 ? 67.030 -18.461 32.278  1.00 41.23 ?  225 GLY A N   1 
ATOM   1647 C CA  . GLY A 1 235 ? 68.216 -18.741 31.500  1.00 43.19 ?  225 GLY A CA  1 
ATOM   1648 C C   . GLY A 1 235 ? 68.101 -20.084 30.802  1.00 42.33 ?  225 GLY A C   1 
ATOM   1649 O O   . GLY A 1 235 ? 68.031 -21.127 31.450  1.00 46.36 ?  225 GLY A O   1 
ATOM   1650 N N   . VAL A 1 236 ? 68.105 -20.051 29.472  1.00 36.26 ?  226 VAL A N   1 
ATOM   1651 C CA  . VAL A 1 236 ? 67.907 -21.253 28.661  1.00 38.71 ?  226 VAL A CA  1 
ATOM   1652 C C   . VAL A 1 236 ? 69.220 -22.023 28.568  1.00 36.78 ?  226 VAL A C   1 
ATOM   1653 O O   . VAL A 1 236 ? 70.197 -21.533 27.990  1.00 41.05 ?  226 VAL A O   1 
ATOM   1654 C CB  . VAL A 1 236 ? 67.394 -20.883 27.263  1.00 31.93 ?  226 VAL A CB  1 
ATOM   1655 C CG1 . VAL A 1 236 ? 67.330 -22.138 26.358  1.00 36.25 ?  226 VAL A CG1 1 
ATOM   1656 C CG2 . VAL A 1 236 ? 66.052 -20.190 27.372  1.00 35.24 ?  226 VAL A CG2 1 
ATOM   1657 N N   . ASN A 1 237 ? 69.243 -23.242 29.120  1.00 34.53 ?  227 ASN A N   1 
ATOM   1658 C CA  . ASN A 1 237 ? 70.451 -24.071 29.113  1.00 36.56 ?  227 ASN A CA  1 
ATOM   1659 C C   . ASN A 1 237 ? 70.332 -25.360 28.315  1.00 40.57 ?  227 ASN A C   1 
ATOM   1660 O O   . ASN A 1 237 ? 71.357 -26.006 28.065  1.00 40.95 ?  227 ASN A O   1 
ATOM   1661 C CB  . ASN A 1 237 ? 70.856 -24.443 30.546  1.00 37.36 ?  227 ASN A CB  1 
ATOM   1662 C CG  . ASN A 1 237 ? 71.195 -23.237 31.371  1.00 41.82 ?  227 ASN A CG  1 
ATOM   1663 O OD1 . ASN A 1 237 ? 71.778 -22.278 30.860  1.00 45.01 ?  227 ASN A OD1 1 
ATOM   1664 N ND2 . ASN A 1 237 ? 70.835 -23.268 32.659  1.00 49.34 ?  227 ASN A ND2 1 
ATOM   1665 N N   . ASP A 1 238 ? 69.127 -25.787 27.960  1.00 31.69 ?  228 ASP A N   1 
ATOM   1666 C CA  . ASP A 1 238 ? 68.944 -26.962 27.115  1.00 33.01 ?  228 ASP A CA  1 
ATOM   1667 C C   . ASP A 1 238 ? 67.692 -26.725 26.277  1.00 37.80 ?  228 ASP A C   1 
ATOM   1668 O O   . ASP A 1 238 ? 67.051 -25.671 26.376  1.00 31.98 ?  228 ASP A O   1 
ATOM   1669 C CB  . ASP A 1 238 ? 68.927 -28.251 27.952  1.00 31.27 ?  228 ASP A CB  1 
ATOM   1670 C CG  . ASP A 1 238 ? 67.701 -28.374 28.858  1.00 39.94 ?  228 ASP A CG  1 
ATOM   1671 O OD1 . ASP A 1 238 ? 66.581 -27.956 28.493  1.00 34.95 ?  228 ASP A OD1 1 
ATOM   1672 O OD2 . ASP A 1 238 ? 67.868 -28.920 29.965  1.00 46.54 -1 228 ASP A OD2 1 
ATOM   1673 N N   . ARG A 1 239 ? 67.360 -27.697 25.424  1.00 31.67 ?  229 ARG A N   1 
ATOM   1674 C CA  . ARG A 1 239 ? 66.265 -27.504 24.476  1.00 31.22 ?  229 ARG A CA  1 
ATOM   1675 C C   . ARG A 1 239 ? 64.902 -27.714 25.112  1.00 31.26 ?  229 ARG A C   1 
ATOM   1676 O O   . ARG A 1 239 ? 63.899 -27.239 24.571  1.00 25.97 ?  229 ARG A O   1 
ATOM   1677 C CB  . ARG A 1 239 ? 66.465 -28.432 23.280  1.00 37.17 ?  229 ARG A CB  1 
ATOM   1678 C CG  . ARG A 1 239 ? 67.767 -28.089 22.563  1.00 35.80 ?  229 ARG A CG  1 
ATOM   1679 C CD  . ARG A 1 239 ? 67.797 -28.493 21.107  1.00 38.16 ?  229 ARG A CD  1 
ATOM   1680 N NE  . ARG A 1 239 ? 69.178 -28.726 20.677  1.00 38.16 ?  229 ARG A NE  1 
ATOM   1681 C CZ  . ARG A 1 239 ? 69.640 -28.417 19.472  1.00 37.90 ?  229 ARG A CZ  1 
ATOM   1682 N NH1 . ARG A 1 239 ? 68.844 -27.916 18.537  1.00 32.79 ?  229 ARG A NH1 1 
ATOM   1683 N NH2 . ARG A 1 239 ? 70.925 -28.647 19.186  1.00 32.45 ?  229 ARG A NH2 1 
ATOM   1684 N N   . VAL A 1 240 ? 64.835 -28.386 26.264  1.00 34.38 ?  230 VAL A N   1 
ATOM   1685 C CA  . VAL A 1 240 ? 63.577 -28.406 26.999  1.00 31.38 ?  230 VAL A CA  1 
ATOM   1686 C C   . VAL A 1 240 ? 63.262 -27.003 27.497  1.00 34.17 ?  230 VAL A C   1 
ATOM   1687 O O   . VAL A 1 240 ? 62.146 -26.499 27.334  1.00 33.63 ?  230 VAL A O   1 
ATOM   1688 C CB  . VAL A 1 240 ? 63.621 -29.441 28.144  1.00 36.01 ?  230 VAL A CB  1 
ATOM   1689 C CG1 . VAL A 1 240 ? 62.282 -29.457 28.901  1.00 31.34 ?  230 VAL A CG1 1 
ATOM   1690 C CG2 . VAL A 1 240 ? 63.853 -30.865 27.575  1.00 31.70 ?  230 VAL A CG2 1 
ATOM   1691 N N   . MET A 1 241 ? 64.261 -26.344 28.084  1.00 31.54 ?  231 MET A N   1 
ATOM   1692 C CA  . MET A 1 241 ? 64.112 -24.966 28.539  1.00 35.02 ?  231 MET A CA  1 
ATOM   1693 C C   . MET A 1 241 ? 63.842 -24.023 27.371  1.00 32.04 ?  231 MET A C   1 
ATOM   1694 O O   . MET A 1 241 ? 63.104 -23.038 27.512  1.00 30.73 ?  231 MET A O   1 
ATOM   1695 C CB  . MET A 1 241 ? 65.387 -24.537 29.271  1.00 33.89 ?  231 MET A CB  1 
ATOM   1696 C CG  . MET A 1 241 ? 65.649 -25.358 30.531  1.00 40.76 ?  231 MET A CG  1 
ATOM   1697 S SD  . MET A 1 241 ? 67.114 -24.830 31.455  1.00 40.71 ?  231 MET A SD  1 
ATOM   1698 C CE  . MET A 1 241 ? 66.362 -23.477 32.371  1.00 36.93 ?  231 MET A CE  1 
ATOM   1699 N N   . LEU A 1 242 ? 64.474 -24.285 26.222  1.00 31.24 ?  232 LEU A N   1 
ATOM   1700 C CA  . LEU A 1 242 ? 64.156 -23.528 25.016  1.00 31.04 ?  232 LEU A CA  1 
ATOM   1701 C C   . LEU A 1 242 ? 62.664 -23.614 24.697  1.00 30.58 ?  232 LEU A C   1 
ATOM   1702 O O   . LEU A 1 242 ? 62.036 -22.595 24.377  1.00 30.01 ?  232 LEU A O   1 
ATOM   1703 C CB  . LEU A 1 242 ? 64.974 -24.042 23.834  1.00 25.84 ?  232 LEU A CB  1 
ATOM   1704 C CG  . LEU A 1 242 ? 64.870 -23.206 22.563  1.00 31.58 ?  232 LEU A CG  1 
ATOM   1705 C CD1 . LEU A 1 242 ? 65.409 -21.774 22.801  1.00 33.29 ?  232 LEU A CD1 1 
ATOM   1706 C CD2 . LEU A 1 242 ? 65.549 -23.867 21.383  1.00 33.01 ?  232 LEU A CD2 1 
ATOM   1707 N N   . SER A 1 243 ? 62.070 -24.814 24.817  1.00 27.25 ?  233 SER A N   1 
ATOM   1708 C CA  . SER A 1 243 ? 60.642 -24.946 24.533  1.00 31.64 ?  233 SER A CA  1 
ATOM   1709 C C   . SER A 1 243 ? 59.807 -24.265 25.604  1.00 34.43 ?  233 SER A C   1 
ATOM   1710 O O   . SER A 1 243 ? 58.706 -23.785 25.311  1.00 32.40 ?  233 SER A O   1 
ATOM   1711 C CB  . SER A 1 243 ? 60.222 -26.422 24.380  1.00 32.92 ?  233 SER A CB  1 
ATOM   1712 O OG  . SER A 1 243 ? 60.252 -27.170 25.597  1.00 27.18 ?  233 SER A OG  1 
ATOM   1713 N N   . GLN A 1 244 ? 60.311 -24.200 26.840  1.00 30.97 ?  234 GLN A N   1 
ATOM   1714 C CA  . GLN A 1 244 ? 59.598 -23.473 27.885  1.00 33.02 ?  234 GLN A CA  1 
ATOM   1715 C C   . GLN A 1 244 ? 59.633 -21.974 27.636  1.00 34.39 ?  234 GLN A C   1 
ATOM   1716 O O   . GLN A 1 244 ? 58.668 -21.270 27.961  1.00 32.76 ?  234 GLN A O   1 
ATOM   1717 C CB  . GLN A 1 244 ? 60.188 -23.839 29.257  1.00 32.67 ?  234 GLN A CB  1 
ATOM   1718 C CG  . GLN A 1 244 ? 59.926 -25.325 29.562  1.00 34.65 ?  234 GLN A CG  1 
ATOM   1719 C CD  . GLN A 1 244 ? 60.683 -25.866 30.770  1.00 46.80 ?  234 GLN A CD  1 
ATOM   1720 O OE1 . GLN A 1 244 ? 61.710 -25.318 31.175  1.00 38.55 ?  234 GLN A OE1 1 
ATOM   1721 N NE2 . GLN A 1 244 ? 60.214 -26.992 31.302  1.00 45.79 ?  234 GLN A NE2 1 
ATOM   1722 N N   . ALA A 1 245 ? 60.724 -21.477 27.040  1.00 31.94 ?  235 ALA A N   1 
ATOM   1723 C CA  . ALA A 1 245 ? 60.790 -20.070 26.673  1.00 33.12 ?  235 ALA A CA  1 
ATOM   1724 C C   . ALA A 1 245 ? 59.810 -19.758 25.553  1.00 33.42 ?  235 ALA A C   1 
ATOM   1725 O O   . ALA A 1 245 ? 59.182 -18.694 25.553  1.00 33.23 ?  235 ALA A O   1 
ATOM   1726 C CB  . ALA A 1 245 ? 62.225 -19.686 26.270  1.00 29.81 ?  235 ALA A CB  1 
ATOM   1727 N N   . GLU A 1 246 ? 59.632 -20.686 24.609  1.00 30.78 ?  236 GLU A N   1 
ATOM   1728 C CA  . GLU A 1 246 ? 58.662 -20.447 23.547  1.00 30.57 ?  236 GLU A CA  1 
ATOM   1729 C C   . GLU A 1 246 ? 57.254 -20.343 24.122  1.00 30.37 ?  236 GLU A C   1 
ATOM   1730 O O   . GLU A 1 246 ? 56.496 -19.418 23.790  1.00 29.18 ?  236 GLU A O   1 
ATOM   1731 C CB  . GLU A 1 246 ? 58.725 -21.563 22.499  1.00 32.74 ?  236 GLU A CB  1 
ATOM   1732 C CG  . GLU A 1 246 ? 59.992 -21.524 21.667  1.00 40.82 ?  236 GLU A CG  1 
ATOM   1733 C CD  . GLU A 1 246 ? 59.782 -20.869 20.291  1.00 38.98 ?  236 GLU A CD  1 
ATOM   1734 O OE1 . GLU A 1 246 ? 58.793 -20.115 20.106  1.00 37.72 ?  236 GLU A OE1 1 
ATOM   1735 O OE2 . GLU A 1 246 ? 60.617 -21.119 19.400  1.00 35.77 -1 236 GLU A OE2 1 
ATOM   1736 N N   . LYS A 1 247 ? 56.908 -21.259 25.033  1.00 29.30 ?  237 LYS A N   1 
ATOM   1737 C CA  . LYS A 1 247 ? 55.576 -21.241 25.630  1.00 37.38 ?  237 LYS A CA  1 
ATOM   1738 C C   . LYS A 1 247 ? 55.368 -19.974 26.461  1.00 36.42 ?  237 LYS A C   1 
ATOM   1739 O O   . LYS A 1 247 ? 54.274 -19.390 26.455  1.00 33.74 ?  237 LYS A O   1 
ATOM   1740 C CB  . LYS A 1 247 ? 55.367 -22.510 26.469  1.00 38.63 ?  237 LYS A CB  1 
ATOM   1741 C CG  . LYS A 1 247 ? 53.936 -22.746 27.037  1.00 40.26 ?  237 LYS A CG  1 
ATOM   1742 C CD  . LYS A 1 247 ? 52.823 -23.042 26.000  1.00 48.23 ?  237 LYS A CD  1 
ATOM   1743 C CE  . LYS A 1 247 ? 53.272 -23.824 24.749  1.00 53.33 ?  237 LYS A CE  1 
ATOM   1744 N NZ  . LYS A 1 247 ? 52.097 -24.243 23.861  1.00 41.63 ?  237 LYS A NZ  1 
ATOM   1745 N N   . ALA A 1 248 ? 56.414 -19.520 27.164  1.00 32.63 ?  238 ALA A N   1 
ATOM   1746 C CA  . ALA A 1 248 ? 56.300 -18.290 27.943  1.00 34.37 ?  238 ALA A CA  1 
ATOM   1747 C C   . ALA A 1 248 ? 56.091 -17.084 27.031  1.00 33.08 ?  238 ALA A C   1 
ATOM   1748 O O   . ALA A 1 248 ? 55.236 -16.231 27.296  1.00 31.66 ?  238 ALA A O   1 
ATOM   1749 C CB  . ALA A 1 248 ? 57.539 -18.099 28.820  1.00 36.84 ?  238 ALA A CB  1 
ATOM   1750 N N   . MET A 1 249 ? 56.871 -16.989 25.953  1.00 32.42 ?  239 MET A N   1 
ATOM   1751 C CA  . MET A 1 249 ? 56.662 -15.889 25.011  1.00 34.32 ?  239 MET A CA  1 
ATOM   1752 C C   . MET A 1 249 ? 55.310 -15.980 24.324  1.00 34.62 ?  239 MET A C   1 
ATOM   1753 O O   . MET A 1 249 ? 54.668 -14.952 24.064  1.00 34.15 ?  239 MET A O   1 
ATOM   1754 C CB  . MET A 1 249 ? 57.751 -15.838 23.959  1.00 31.61 ?  239 MET A CB  1 
ATOM   1755 C CG  . MET A 1 249 ? 57.761 -14.475 23.253  1.00 44.38 ?  239 MET A CG  1 
ATOM   1756 S SD  . MET A 1 249 ? 59.339 -13.829 22.684  1.00 66.30 ?  239 MET A SD  1 
ATOM   1757 C CE  . MET A 1 249 ? 60.301 -13.788 24.199  1.00 47.35 ?  239 MET A CE  1 
ATOM   1758 N N   . GLN A 1 250 ? 54.874 -17.195 24.004  1.00 30.01 ?  240 GLN A N   1 
ATOM   1759 C CA  . GLN A 1 250 ? 53.556 -17.382 23.398  1.00 34.36 ?  240 GLN A CA  1 
ATOM   1760 C C   . GLN A 1 250 ? 52.458 -16.804 24.276  1.00 31.46 ?  240 GLN A C   1 
ATOM   1761 O O   . GLN A 1 250 ? 51.598 -16.047 23.812  1.00 33.72 ?  240 GLN A O   1 
ATOM   1762 C CB  . GLN A 1 250 ? 53.303 -18.870 23.169  1.00 35.87 ?  240 GLN A CB  1 
ATOM   1763 C CG  . GLN A 1 250 ? 52.189 -19.156 22.181  1.00 34.64 ?  240 GLN A CG  1 
ATOM   1764 C CD  . GLN A 1 250 ? 51.647 -20.560 22.349  1.00 41.15 ?  240 GLN A CD  1 
ATOM   1765 O OE1 . GLN A 1 250 ? 51.731 -21.149 23.425  1.00 37.63 ?  240 GLN A OE1 1 
ATOM   1766 N NE2 . GLN A 1 250 ? 51.191 -21.140 21.262  1.00 29.75 ?  240 GLN A NE2 1 
ATOM   1767 N N   . ARG A 1 251 ? 52.476 -17.149 25.557  1.00 30.87 ?  241 ARG A N   1 
ATOM   1768 C CA  . ARG A 1 251 ? 51.440 -16.675 26.464  1.00 35.69 ?  241 ARG A CA  1 
ATOM   1769 C C   . ARG A 1 251 ? 51.503 -15.160 26.645  1.00 33.32 ?  241 ARG A C   1 
ATOM   1770 O O   . ARG A 1 251 ? 50.468 -14.484 26.608  1.00 33.47 ?  241 ARG A O   1 
ATOM   1771 C CB  . ARG A 1 251 ? 51.584 -17.420 27.785  1.00 43.19 ?  241 ARG A CB  1 
ATOM   1772 C CG  . ARG A 1 251 ? 50.982 -16.780 29.019  1.00 56.51 ?  241 ARG A CG  1 
ATOM   1773 C CD  . ARG A 1 251 ? 50.777 -17.834 30.138  1.00 62.26 ?  241 ARG A CD  1 
ATOM   1774 N NE  . ARG A 1 251 ? 50.415 -19.158 29.620  1.00 76.48 ?  241 ARG A NE  1 
ATOM   1775 C CZ  . ARG A 1 251 ? 51.272 -20.133 29.325  1.00 73.54 ?  241 ARG A CZ  1 
ATOM   1776 N NH1 . ARG A 1 251 ? 52.563 -20.025 29.599  1.00 66.99 ?  241 ARG A NH1 1 
ATOM   1777 N NH2 . ARG A 1 251 ? 50.820 -21.243 28.735  1.00 56.97 ?  241 ARG A NH2 1 
ATOM   1778 N N   . ARG A 1 252 ? 52.706 -14.603 26.798  1.00 34.65 ?  242 ARG A N   1 
ATOM   1779 C CA  . ARG A 1 252 ? 52.879 -13.148 26.857  1.00 37.41 ?  242 ARG A CA  1 
ATOM   1780 C C   . ARG A 1 252 ? 52.242 -12.443 25.668  1.00 36.90 ?  242 ARG A C   1 
ATOM   1781 O O   . ARG A 1 252 ? 51.426 -11.523 25.823  1.00 31.83 ?  242 ARG A O   1 
ATOM   1782 C CB  . ARG A 1 252 ? 54.373 -12.802 26.918  1.00 36.74 ?  242 ARG A CB  1 
ATOM   1783 C CG  . ARG A 1 252 ? 54.664 -11.318 27.217  1.00 42.00 ?  242 ARG A CG  1 
ATOM   1784 C CD  . ARG A 1 252 ? 56.118 -10.954 26.899  1.00 42.30 ?  242 ARG A CD  1 
ATOM   1785 N NE  . ARG A 1 252 ? 56.949 -11.283 28.046  1.00 46.96 ?  242 ARG A NE  1 
ATOM   1786 C CZ  . ARG A 1 252 ? 58.276 -11.246 28.073  1.00 43.42 ?  242 ARG A CZ  1 
ATOM   1787 N NH1 . ARG A 1 252 ? 58.983 -10.832 27.036  1.00 39.44 ?  242 ARG A NH1 1 
ATOM   1788 N NH2 . ARG A 1 252 ? 58.909 -11.651 29.166  1.00 44.37 ?  242 ARG A NH2 1 
ATOM   1789 N N   . THR A 1 253 ? 52.644 -12.840 24.466  1.00 31.02 ?  243 THR A N   1 
ATOM   1790 C CA  . THR A 1 253 ? 52.193 -12.143 23.270  1.00 31.64 ?  243 THR A CA  1 
ATOM   1791 C C   . THR A 1 253 ? 50.703 -12.330 23.038  1.00 32.01 ?  243 THR A C   1 
ATOM   1792 O O   . THR A 1 253 ? 49.999 -11.366 22.712  1.00 32.60 ?  243 THR A O   1 
ATOM   1793 C CB  . THR A 1 253 ? 53.001 -12.631 22.076  1.00 38.52 ?  243 THR A CB  1 
ATOM   1794 O OG1 . THR A 1 253 ? 54.368 -12.234 22.266  1.00 38.78 ?  243 THR A OG1 1 
ATOM   1795 C CG2 . THR A 1 253 ? 52.489 -12.027 20.791  1.00 37.28 ?  243 THR A CG2 1 
ATOM   1796 N N   . ASN A 1 254 ? 50.197 -13.563 23.193  1.00 30.87 ?  244 ASN A N   1 
ATOM   1797 C CA  . ASN A 1 254 ? 48.787 -13.811 22.884  1.00 27.06 ?  244 ASN A CA  1 
ATOM   1798 C C   . ASN A 1 254 ? 47.862 -13.079 23.858  1.00 32.49 ?  244 ASN A C   1 
ATOM   1799 O O   . ASN A 1 254 ? 46.836 -12.515 23.452  1.00 29.82 ?  244 ASN A O   1 
ATOM   1800 C CB  . ASN A 1 254 ? 48.501 -15.313 22.905  1.00 27.46 ?  244 ASN A CB  1 
ATOM   1801 C CG  . ASN A 1 254 ? 49.203 -16.050 21.785  1.00 35.44 ?  244 ASN A CG  1 
ATOM   1802 O OD1 . ASN A 1 254 ? 49.797 -15.428 20.893  1.00 40.25 ?  244 ASN A OD1 1 
ATOM   1803 N ND2 . ASN A 1 254 ? 49.086 -17.382 21.784  1.00 31.86 ?  244 ASN A ND2 1 
ATOM   1804 N N   . HIS A 1 255 ? 48.197 -13.096 25.154  1.00 28.68 ?  245 HIS A N   1 
ATOM   1805 C CA  . HIS A 1 255 ? 47.452 -12.303 26.121  1.00 31.65 ?  245 HIS A CA  1 
ATOM   1806 C C   . HIS A 1 255 ? 47.442 -10.824 25.727  1.00 36.86 ?  245 HIS A C   1 
ATOM   1807 O O   . HIS A 1 255 ? 46.398 -10.166 25.786  1.00 34.74 ?  245 HIS A O   1 
ATOM   1808 C CB  . HIS A 1 255 ? 48.055 -12.498 27.513  1.00 35.43 ?  245 HIS A CB  1 
ATOM   1809 C CG  . HIS A 1 255 ? 47.087 -12.262 28.635  1.00 47.23 ?  245 HIS A CG  1 
ATOM   1810 N ND1 . HIS A 1 255 ? 46.158 -13.206 29.025  1.00 57.37 ?  245 HIS A ND1 1 
ATOM   1811 C CD2 . HIS A 1 255 ? 46.911 -11.197 29.459  1.00 57.09 ?  245 HIS A CD2 1 
ATOM   1812 C CE1 . HIS A 1 255 ? 45.446 -12.730 30.033  1.00 49.74 ?  245 HIS A CE1 1 
ATOM   1813 N NE2 . HIS A 1 255 ? 45.881 -11.513 30.316  1.00 45.56 ?  245 HIS A NE2 1 
ATOM   1814 N N   . TYR A 1 256 ? 48.586 -10.291 25.294  1.00 34.40 ?  246 TYR A N   1 
ATOM   1815 C CA  . TYR A 1 256 ? 48.625 -8.892  24.881  1.00 36.17 ?  246 TYR A CA  1 
ATOM   1816 C C   . TYR A 1 256 ? 47.618 -8.627  23.770  1.00 35.65 ?  246 TYR A C   1 
ATOM   1817 O O   . TYR A 1 256 ? 46.829 -7.683  23.847  1.00 29.96 ?  246 TYR A O   1 
ATOM   1818 C CB  . TYR A 1 256 ? 50.041 -8.500  24.445  1.00 36.77 ?  246 TYR A CB  1 
ATOM   1819 C CG  . TYR A 1 256 ? 50.085 -7.147  23.767  1.00 41.54 ?  246 TYR A CG  1 
ATOM   1820 C CD1 . TYR A 1 256 ? 50.104 -5.973  24.514  1.00 36.64 ?  246 TYR A CD1 1 
ATOM   1821 C CD2 . TYR A 1 256 ? 50.082 -7.041  22.382  1.00 38.83 ?  246 TYR A CD2 1 
ATOM   1822 C CE1 . TYR A 1 256 ? 50.129 -4.729  23.899  1.00 37.22 ?  246 TYR A CE1 1 
ATOM   1823 C CE2 . TYR A 1 256 ? 50.098 -5.803  21.758  1.00 38.72 ?  246 TYR A CE2 1 
ATOM   1824 C CZ  . TYR A 1 256 ? 50.118 -4.654  22.522  1.00 42.89 ?  246 TYR A CZ  1 
ATOM   1825 O OH  . TYR A 1 256 ? 50.140 -3.420  21.899  1.00 56.41 ?  246 TYR A OH  1 
ATOM   1826 N N   . HIS A 1 257 ? 47.603 -9.476  22.738  1.00 32.50 ?  247 HIS A N   1 
ATOM   1827 C CA  . HIS A 1 257 ? 46.733 -9.225  21.589  1.00 33.54 ?  247 HIS A CA  1 
ATOM   1828 C C   . HIS A 1 257 ? 45.260 -9.415  21.933  1.00 33.43 ?  247 HIS A C   1 
ATOM   1829 O O   . HIS A 1 257 ? 44.411 -8.642  21.472  1.00 31.35 ?  247 HIS A O   1 
ATOM   1830 C CB  . HIS A 1 257 ? 47.141 -10.124 20.418  1.00 27.18 ?  247 HIS A CB  1 
ATOM   1831 C CG  . HIS A 1 257 ? 48.420 -9.707  19.778  1.00 26.72 ?  247 HIS A CG  1 
ATOM   1832 N ND1 . HIS A 1 257 ? 48.573 -8.480  19.169  1.00 27.58 ?  247 HIS A ND1 1 
ATOM   1833 C CD2 . HIS A 1 257 ? 49.616 -10.339 19.666  1.00 26.50 ?  247 HIS A CD2 1 
ATOM   1834 C CE1 . HIS A 1 257 ? 49.808 -8.375  18.699  1.00 27.57 ?  247 HIS A CE1 1 
ATOM   1835 N NE2 . HIS A 1 257 ? 50.462 -9.488  18.989  1.00 35.08 ?  247 HIS A NE2 1 
ATOM   1836 N N   . MET A 1 258 ? 44.927 -10.432 22.737  1.00 29.95 ?  248 MET A N   1 
ATOM   1837 C CA  . MET A 1 258 ? 43.535 -10.618 23.123  1.00 29.50 ?  248 MET A CA  1 
ATOM   1838 C C   . MET A 1 258 ? 43.011 -9.404  23.882  1.00 30.48 ?  248 MET A C   1 
ATOM   1839 O O   . MET A 1 258 ? 41.894 -8.938  23.632  1.00 26.11 ?  248 MET A O   1 
ATOM   1840 C CB  . MET A 1 258 ? 43.378 -11.911 23.939  1.00 30.57 ?  248 MET A CB  1 
ATOM   1841 C CG  . MET A 1 258 ? 43.571 -13.199 23.097  1.00 27.69 ?  248 MET A CG  1 
ATOM   1842 S SD  . MET A 1 258 ? 43.128 -14.758 23.919  1.00 31.99 ?  248 MET A SD  1 
ATOM   1843 C CE  . MET A 1 258 ? 44.687 -15.039 24.744  1.00 30.75 ?  248 MET A CE  1 
ATOM   1844 N N   . LEU A 1 259 ? 43.794 -8.885  24.831  1.00 30.74 ?  249 LEU A N   1 
ATOM   1845 C CA  . LEU A 1 259 ? 43.300 -7.719  25.558  1.00 37.15 ?  249 LEU A CA  1 
ATOM   1846 C C   . LEU A 1 259 ? 43.323 -6.452  24.702  1.00 40.31 ?  249 LEU A C   1 
ATOM   1847 O O   . LEU A 1 259 ? 42.718 -5.438  25.096  1.00 38.06 ?  249 LEU A O   1 
ATOM   1848 C CB  . LEU A 1 259 ? 44.085 -7.525  26.863  1.00 30.18 ?  249 LEU A CB  1 
ATOM   1849 C CG  . LEU A 1 259 ? 43.864 -8.635  27.902  1.00 39.56 ?  249 LEU A CG  1 
ATOM   1850 C CD1 . LEU A 1 259 ? 44.728 -8.424  29.138  1.00 45.22 ?  249 LEU A CD1 1 
ATOM   1851 C CD2 . LEU A 1 259 ? 42.386 -8.739  28.281  1.00 39.26 ?  249 LEU A CD2 1 
ATOM   1852 N N   . ASN A 1 260 ? 43.965 -6.504  23.531  1.00 34.83 ?  250 ASN A N   1 
ATOM   1853 C CA  . ASN A 1 260 ? 43.995 -5.400  22.577  1.00 31.95 ?  250 ASN A CA  1 
ATOM   1854 C C   . ASN A 1 260 ? 42.949 -5.550  21.467  1.00 33.73 ?  250 ASN A C   1 
ATOM   1855 O O   . ASN A 1 260 ? 42.964 -4.778  20.497  1.00 34.58 ?  250 ASN A O   1 
ATOM   1856 C CB  . ASN A 1 260 ? 45.406 -5.281  21.982  1.00 31.29 ?  250 ASN A CB  1 
ATOM   1857 C CG  . ASN A 1 260 ? 45.778 -3.848  21.609  1.00 41.79 ?  250 ASN A CG  1 
ATOM   1858 O OD1 . ASN A 1 260 ? 45.494 -2.906  22.352  1.00 44.84 ?  250 ASN A OD1 1 
ATOM   1859 N ND2 . ASN A 1 260 ? 46.456 -3.689  20.469  1.00 40.57 ?  250 ASN A ND2 1 
ATOM   1860 N N   . GLY A 1 261 ? 42.056 -6.530  21.574  1.00 29.17 ?  251 GLY A N   1 
ATOM   1861 C CA  . GLY A 1 261 ? 40.947 -6.667  20.639  1.00 28.62 ?  251 GLY A CA  1 
ATOM   1862 C C   . GLY A 1 261 ? 41.114 -7.699  19.536  1.00 32.04 ?  251 GLY A C   1 
ATOM   1863 O O   . GLY A 1 261 ? 40.365 -7.653  18.557  1.00 31.70 ?  251 GLY A O   1 
ATOM   1864 N N   . VAL A 1 262 ? 42.062 -8.623  19.659  1.00 28.99 ?  252 VAL A N   1 
ATOM   1865 C CA  . VAL A 1 262 ? 42.257 -9.673  18.669  1.00 28.53 ?  252 VAL A CA  1 
ATOM   1866 C C   . VAL A 1 262 ? 41.655 -10.949 19.241  1.00 33.75 ?  252 VAL A C   1 
ATOM   1867 O O   . VAL A 1 262 ? 41.978 -11.342 20.376  1.00 28.68 ?  252 VAL A O   1 
ATOM   1868 C CB  . VAL A 1 262 ? 43.752 -9.864  18.356  1.00 29.92 ?  252 VAL A CB  1 
ATOM   1869 C CG1 . VAL A 1 262 ? 43.957 -10.916 17.266  1.00 25.24 ?  252 VAL A CG1 1 
ATOM   1870 C CG2 . VAL A 1 262 ? 44.429 -8.519  17.969  1.00 31.13 ?  252 VAL A CG2 1 
ATOM   1871 N N   . THR A 1 263 ? 40.770 -11.591 18.477  1.00 25.04 ?  253 THR A N   1 
ATOM   1872 C CA  . THR A 1 263 ? 40.291 -12.915 18.854  1.00 25.81 ?  253 THR A CA  1 
ATOM   1873 C C   . THR A 1 263 ? 41.288 -13.979 18.416  1.00 27.97 ?  253 THR A C   1 
ATOM   1874 O O   . THR A 1 263 ? 41.650 -14.066 17.231  1.00 22.79 ?  253 THR A O   1 
ATOM   1875 C CB  . THR A 1 263 ? 38.915 -13.201 18.246  1.00 28.26 ?  253 THR A CB  1 
ATOM   1876 O OG1 . THR A 1 263 ? 37.943 -12.360 18.880  1.00 32.60 ?  253 THR A OG1 1 
ATOM   1877 C CG2 . THR A 1 263 ? 38.525 -14.668 18.480  1.00 28.35 ?  253 THR A CG2 1 
ATOM   1878 N N   . ILE A 1 264 ? 41.706 -14.806 19.370  1.00 25.80 ?  254 ILE A N   1 
ATOM   1879 C CA  . ILE A 1 264 ? 42.589 -15.932 19.121  1.00 29.19 ?  254 ILE A CA  1 
ATOM   1880 C C   . ILE A 1 264 ? 41.846 -17.191 19.565  1.00 31.92 ?  254 ILE A C   1 
ATOM   1881 O O   . ILE A 1 264 ? 41.557 -17.376 20.758  1.00 26.90 ?  254 ILE A O   1 
ATOM   1882 C CB  . ILE A 1 264 ? 43.932 -15.777 19.836  1.00 33.84 ?  254 ILE A CB  1 
ATOM   1883 C CG1 . ILE A 1 264 ? 44.605 -14.496 19.362  1.00 29.68 ?  254 ILE A CG1 1 
ATOM   1884 C CG2 . ILE A 1 264 ? 44.850 -16.960 19.530  1.00 29.01 ?  254 ILE A CG2 1 
ATOM   1885 C CD1 . ILE A 1 264 ? 45.827 -14.118 20.153  1.00 28.99 ?  254 ILE A CD1 1 
ATOM   1886 N N   . ILE A 1 265 ? 41.481 -18.029 18.598  1.00 29.68 ?  255 ILE A N   1 
ATOM   1887 C CA  . ILE A 1 265 ? 40.570 -19.132 18.888  1.00 33.94 ?  255 ILE A CA  1 
ATOM   1888 C C   . ILE A 1 265 ? 41.220 -20.133 19.844  1.00 36.58 ?  255 ILE A C   1 
ATOM   1889 O O   . ILE A 1 265 ? 40.588 -20.567 20.815  1.00 33.56 ?  255 ILE A O   1 
ATOM   1890 C CB  . ILE A 1 265 ? 40.080 -19.787 17.580  1.00 29.52 ?  255 ILE A CB  1 
ATOM   1891 C CG1 . ILE A 1 265 ? 39.116 -18.837 16.855  1.00 28.96 ?  255 ILE A CG1 1 
ATOM   1892 C CG2 . ILE A 1 265 ? 39.358 -21.142 17.860  1.00 36.41 ?  255 ILE A CG2 1 
ATOM   1893 C CD1 . ILE A 1 265 ? 38.695 -19.271 15.457  1.00 31.37 ?  255 ILE A CD1 1 
ATOM   1894 N N   . ASP A 1 266 ? 42.497 -20.477 19.620  1.00 30.36 ?  256 ASP A N   1 
ATOM   1895 C CA  . ASP A 1 266 ? 43.227 -21.390 20.505  1.00 33.03 ?  256 ASP A CA  1 
ATOM   1896 C C   . ASP A 1 266 ? 44.623 -20.846 20.766  1.00 36.22 ?  256 ASP A C   1 
ATOM   1897 O O   . ASP A 1 266 ? 45.582 -21.206 20.067  1.00 30.42 ?  256 ASP A O   1 
ATOM   1898 C CB  . ASP A 1 266 ? 43.329 -22.799 19.911  1.00 33.85 ?  256 ASP A CB  1 
ATOM   1899 C CG  . ASP A 1 266 ? 43.968 -23.790 20.879  1.00 42.22 ?  256 ASP A CG  1 
ATOM   1900 O OD1 . ASP A 1 266 ? 44.225 -23.412 22.052  1.00 44.96 ?  256 ASP A OD1 1 
ATOM   1901 O OD2 . ASP A 1 266 ? 44.259 -24.935 20.466  1.00 42.16 ?  256 ASP A OD2 1 
ATOM   1902 N N   . PRO A 1 267 ? 44.790 -20.007 21.796  1.00 33.39 ?  257 PRO A N   1 
ATOM   1903 C CA  . PRO A 1 267 ? 46.110 -19.381 22.019  1.00 34.03 ?  257 PRO A CA  1 
ATOM   1904 C C   . PRO A 1 267 ? 47.225 -20.356 22.344  1.00 36.21 ?  257 PRO A C   1 
ATOM   1905 O O   . PRO A 1 267 ? 48.393 -19.988 22.193  1.00 34.25 ?  257 PRO A O   1 
ATOM   1906 C CB  . PRO A 1 267 ? 45.858 -18.413 23.188  1.00 34.14 ?  257 PRO A CB  1 
ATOM   1907 C CG  . PRO A 1 267 ? 44.501 -18.805 23.749  1.00 40.85 ?  257 PRO A CG  1 
ATOM   1908 C CD  . PRO A 1 267 ? 43.734 -19.344 22.576  1.00 36.42 ?  257 PRO A CD  1 
ATOM   1909 N N   . ASP A 1 268 ? 46.915 -21.572 22.793  1.00 36.33 ?  258 ASP A N   1 
ATOM   1910 C CA  . ASP A 1 268 ? 47.965 -22.557 23.047  1.00 36.29 ?  258 ASP A CA  1 
ATOM   1911 C C   . ASP A 1 268 ? 48.588 -23.080 21.768  1.00 33.30 ?  258 ASP A C   1 
ATOM   1912 O O   . ASP A 1 268 ? 49.692 -23.632 21.819  1.00 36.49 ?  258 ASP A O   1 
ATOM   1913 C CB  . ASP A 1 268 ? 47.418 -23.740 23.847  1.00 34.75 ?  258 ASP A CB  1 
ATOM   1914 C CG  . ASP A 1 268 ? 47.158 -23.387 25.305  1.00 51.81 ?  258 ASP A CG  1 
ATOM   1915 O OD1 . ASP A 1 268 ? 47.968 -22.629 25.885  1.00 45.92 ?  258 ASP A OD1 1 
ATOM   1916 O OD2 . ASP A 1 268 ? 46.163 -23.887 25.874  1.00 50.07 ?  258 ASP A OD2 1 
ATOM   1917 N N   . SER A 1 269 ? 47.893 -22.944 20.635  1.00 28.13 ?  259 SER A N   1 
ATOM   1918 C CA  . SER A 1 269 ? 48.351 -23.457 19.349  1.00 32.41 ?  259 SER A CA  1 
ATOM   1919 C C   . SER A 1 269 ? 48.602 -22.342 18.340  1.00 30.91 ?  259 SER A C   1 
ATOM   1920 O O   . SER A 1 269 ? 48.680 -22.607 17.143  1.00 31.66 ?  259 SER A O   1 
ATOM   1921 C CB  . SER A 1 269 ? 47.334 -24.434 18.768  1.00 37.18 ?  259 SER A CB  1 
ATOM   1922 O OG  . SER A 1 269 ? 46.137 -23.732 18.404  1.00 49.41 ?  259 SER A OG  1 
ATOM   1923 N N   . THR A 1 270 ? 48.718 -21.101 18.793  1.00 31.55 ?  260 THR A N   1 
ATOM   1924 C CA  . THR A 1 270 ? 48.859 -19.946 17.911  1.00 24.91 ?  260 THR A CA  1 
ATOM   1925 C C   . THR A 1 270 ? 50.170 -19.276 18.262  1.00 29.12 ?  260 THR A C   1 
ATOM   1926 O O   . THR A 1 270 ? 50.474 -19.092 19.450  1.00 31.45 ?  260 THR A O   1 
ATOM   1927 C CB  . THR A 1 270 ? 47.668 -18.995 18.092  1.00 28.48 ?  260 THR A CB  1 
ATOM   1928 O OG1 . THR A 1 270 ? 46.467 -19.715 17.814  1.00 35.16 ?  260 THR A OG1 1 
ATOM   1929 C CG2 . THR A 1 270 ? 47.779 -17.773 17.189  1.00 25.85 ?  260 THR A CG2 1 
ATOM   1930 N N   . TYR A 1 271 ? 50.972 -18.970 17.250  1.00 22.09 ?  261 TYR A N   1 
ATOM   1931 C CA  . TYR A 1 271 ? 52.355 -18.539 17.471  1.00 26.00 ?  261 TYR A CA  1 
ATOM   1932 C C   . TYR A 1 271 ? 52.523 -17.189 16.791  1.00 30.50 ?  261 TYR A C   1 
ATOM   1933 O O   . TYR A 1 271 ? 52.573 -17.114 15.558  1.00 31.81 ?  261 TYR A O   1 
ATOM   1934 C CB  . TYR A 1 271 ? 53.339 -19.581 16.932  1.00 30.69 ?  261 TYR A CB  1 
ATOM   1935 C CG  . TYR A 1 271 ? 52.912 -20.978 17.341  1.00 32.05 ?  261 TYR A CG  1 
ATOM   1936 C CD1 . TYR A 1 271 ? 53.260 -21.512 18.578  1.00 34.27 ?  261 TYR A CD1 1 
ATOM   1937 C CD2 . TYR A 1 271 ? 52.116 -21.744 16.489  1.00 32.90 ?  261 TYR A CD2 1 
ATOM   1938 C CE1 . TYR A 1 271 ? 52.823 -22.772 18.970  1.00 35.58 ?  261 TYR A CE1 1 
ATOM   1939 C CE2 . TYR A 1 271 ? 51.677 -23.011 16.865  1.00 36.38 ?  261 TYR A CE2 1 
ATOM   1940 C CZ  . TYR A 1 271 ? 52.030 -23.519 18.102  1.00 39.14 ?  261 TYR A CZ  1 
ATOM   1941 O OH  . TYR A 1 271 ? 51.567 -24.781 18.447  1.00 34.47 ?  261 TYR A OH  1 
ATOM   1942 N N   . ILE A 1 272 ? 52.583 -16.121 17.582  1.00 26.60 ?  262 ILE A N   1 
ATOM   1943 C CA  . ILE A 1 272 ? 52.722 -14.767 17.052  1.00 27.61 ?  262 ILE A CA  1 
ATOM   1944 C C   . ILE A 1 272 ? 54.022 -14.179 17.591  1.00 30.49 ?  262 ILE A C   1 
ATOM   1945 O O   . ILE A 1 272 ? 54.171 -14.011 18.799  1.00 25.67 ?  262 ILE A O   1 
ATOM   1946 C CB  . ILE A 1 272 ? 51.511 -13.897 17.420  1.00 28.18 ?  262 ILE A CB  1 
ATOM   1947 C CG1 . ILE A 1 272 ? 50.225 -14.576 16.940  1.00 26.75 ?  262 ILE A CG1 1 
ATOM   1948 C CG2 . ILE A 1 272 ? 51.683 -12.454 16.886  1.00 30.72 ?  262 ILE A CG2 1 
ATOM   1949 C CD1 . ILE A 1 272 ? 48.934 -13.868 17.433  1.00 31.03 ?  262 ILE A CD1 1 
ATOM   1950 N N   . GLY A 1 273 ? 54.958 -13.872 16.703  1.00 29.65 ?  263 GLY A N   1 
ATOM   1951 C CA  . GLY A 1 273 ? 56.224 -13.301 17.123  1.00 31.52 ?  263 GLY A CA  1 
ATOM   1952 C C   . GLY A 1 273 ? 56.082 -11.903 17.731  1.00 35.63 ?  263 GLY A C   1 
ATOM   1953 O O   . GLY A 1 273 ? 55.022 -11.266 17.661  1.00 29.34 ?  263 GLY A O   1 
ATOM   1954 N N   . PRO A 1 274 ? 57.164 -11.403 18.346  1.00 34.75 ?  264 PRO A N   1 
ATOM   1955 C CA  . PRO A 1 274 ? 57.073 -10.124 19.085  1.00 36.34 ?  264 PRO A CA  1 
ATOM   1956 C C   . PRO A 1 274 ? 57.056 -8.890  18.208  1.00 35.07 ?  264 PRO A C   1 
ATOM   1957 O O   . PRO A 1 274 ? 56.667 -7.813  18.691  1.00 34.82 ?  264 PRO A O   1 
ATOM   1958 C CB  . PRO A 1 274 ? 58.332 -10.138 19.965  1.00 42.62 ?  264 PRO A CB  1 
ATOM   1959 C CG  . PRO A 1 274 ? 59.317 -10.947 19.166  1.00 41.65 ?  264 PRO A CG  1 
ATOM   1960 C CD  . PRO A 1 274 ? 58.488 -12.036 18.490  1.00 34.37 ?  264 PRO A CD  1 
ATOM   1961 N N   . ASP A 1 275 ? 57.451 -8.991  16.941  1.00 31.96 ?  265 ASP A N   1 
ATOM   1962 C CA  . ASP A 1 275 ? 57.442 -7.828  16.061  1.00 33.76 ?  265 ASP A CA  1 
ATOM   1963 C C   . ASP A 1 275 ? 56.203 -7.792  15.165  1.00 32.84 ?  265 ASP A C   1 
ATOM   1964 O O   . ASP A 1 275 ? 56.214 -7.119  14.125  1.00 33.71 ?  265 ASP A O   1 
ATOM   1965 C CB  . ASP A 1 275 ? 58.697 -7.815  15.192  1.00 34.22 ?  265 ASP A CB  1 
ATOM   1966 C CG  . ASP A 1 275 ? 59.978 -7.739  16.015  1.00 43.66 ?  265 ASP A CG  1 
ATOM   1967 O OD1 . ASP A 1 275 ? 60.039 -6.959  16.985  1.00 47.03 ?  265 ASP A OD1 1 
ATOM   1968 O OD2 . ASP A 1 275 ? 60.910 -8.510  15.717  1.00 44.95 -1 265 ASP A OD2 1 
ATOM   1969 N N   . VAL A 1 276 ? 55.167 -8.528  15.510  1.00 29.61 ?  266 VAL A N   1 
ATOM   1970 C CA  . VAL A 1 276 ? 53.925 -8.512  14.740  1.00 26.01 ?  266 VAL A CA  1 
ATOM   1971 C C   . VAL A 1 276 ? 52.960 -7.502  15.350  1.00 30.44 ?  266 VAL A C   1 
ATOM   1972 O O   . VAL A 1 276 ? 52.763 -7.470  16.574  1.00 29.55 ?  266 VAL A O   1 
ATOM   1973 C CB  . VAL A 1 276 ? 53.300 -9.913  14.712  1.00 27.08 ?  266 VAL A CB  1 
ATOM   1974 C CG1 . VAL A 1 276 ? 51.973 -9.886  13.941  1.00 25.04 ?  266 VAL A CG1 1 
ATOM   1975 C CG2 . VAL A 1 276 ? 54.287 -10.930 14.133  1.00 25.75 ?  266 VAL A CG2 1 
ATOM   1976 N N   . THR A 1 277 ? 52.321 -6.689  14.510  1.00 27.62 ?  267 THR A N   1 
ATOM   1977 C CA  . THR A 1 277 ? 51.223 -5.843  14.973  1.00 25.93 ?  267 THR A CA  1 
ATOM   1978 C C   . THR A 1 277 ? 49.922 -6.303  14.339  1.00 28.08 ?  267 THR A C   1 
ATOM   1979 O O   . THR A 1 277 ? 49.881 -6.619  13.143  1.00 25.88 ?  267 THR A O   1 
ATOM   1980 C CB  . THR A 1 277 ? 51.480 -4.364  14.664  1.00 30.31 ?  267 THR A CB  1 
ATOM   1981 O OG1 . THR A 1 277 ? 51.547 -4.166  13.250  1.00 31.01 ?  267 THR A OG1 1 
ATOM   1982 C CG2 . THR A 1 277 ? 52.811 -3.941  15.283  1.00 34.18 ?  267 THR A CG2 1 
ATOM   1983 N N   . ILE A 1 278 ? 48.869 -6.370  15.144  1.00 25.67 ?  268 ILE A N   1 
ATOM   1984 C CA  . ILE A 1 278 ? 47.584 -6.878  14.690  1.00 25.81 ?  268 ILE A CA  1 
ATOM   1985 C C   . ILE A 1 278 ? 46.471 -5.923  15.109  1.00 31.33 ?  268 ILE A C   1 
ATOM   1986 O O   . ILE A 1 278 ? 46.306 -5.629  16.301  1.00 26.94 ?  268 ILE A O   1 
ATOM   1987 C CB  . ILE A 1 278 ? 47.284 -8.294  15.222  1.00 25.41 ?  268 ILE A CB  1 
ATOM   1988 C CG1 . ILE A 1 278 ? 48.436 -9.267  14.932  1.00 26.16 ?  268 ILE A CG1 1 
ATOM   1989 C CG2 . ILE A 1 278 ? 45.975 -8.775  14.653  1.00 24.44 ?  268 ILE A CG2 1 
ATOM   1990 C CD1 . ILE A 1 278 ? 48.352 -10.515 15.766  1.00 29.05 ?  268 ILE A CD1 1 
ATOM   1991 N N   . GLY A 1 279 ? 45.675 -5.484  14.133  1.00 25.93 ?  269 GLY A N   1 
ATOM   1992 C CA  . GLY A 1 279 ? 44.572 -4.582  14.412  1.00 29.13 ?  269 GLY A CA  1 
ATOM   1993 C C   . GLY A 1 279 ? 43.378 -5.268  15.042  1.00 31.66 ?  269 GLY A C   1 
ATOM   1994 O O   . GLY A 1 279 ? 43.187 -6.490  14.979  1.00 29.40 ?  269 GLY A O   1 
ATOM   1995 N N   . SER A 1 280 ? 42.525 -4.449  15.643  1.00 29.46 ?  270 SER A N   1 
ATOM   1996 C CA  . SER A 1 280 ? 41.399 -4.990  16.389  1.00 34.32 ?  270 SER A CA  1 
ATOM   1997 C C   . SER A 1 280 ? 40.359 -5.622  15.463  1.00 29.13 ?  270 SER A C   1 
ATOM   1998 O O   . SER A 1 280 ? 40.308 -5.360  14.255  1.00 32.95 ?  270 SER A O   1 
ATOM   1999 C CB  . SER A 1 280 ? 40.758 -3.894  17.232  1.00 40.73 ?  270 SER A CB  1 
ATOM   2000 O OG  . SER A 1 280 ? 40.238 -2.889  16.389  1.00 47.37 ?  270 SER A OG  1 
ATOM   2001 N N   . ASP A 1 281 ? 39.529 -6.473  16.062  1.00 27.33 ?  271 ASP A N   1 
ATOM   2002 C CA  . ASP A 1 281 ? 38.453 -7.246  15.440  1.00 33.29 ?  271 ASP A CA  1 
ATOM   2003 C C   . ASP A 1 281 ? 38.977 -8.272  14.436  1.00 31.20 ?  271 ASP A C   1 
ATOM   2004 O O   . ASP A 1 281 ? 38.186 -8.884  13.692  1.00 34.92 ?  271 ASP A O   1 
ATOM   2005 C CB  . ASP A 1 281 ? 37.407 -6.322  14.803  1.00 34.99 ?  271 ASP A CB  1 
ATOM   2006 C CG  . ASP A 1 281 ? 36.345 -5.878  15.808  1.00 35.25 ?  271 ASP A CG  1 
ATOM   2007 O OD1 . ASP A 1 281 ? 36.158 -6.565  16.836  1.00 32.20 ?  271 ASP A OD1 1 
ATOM   2008 O OD2 . ASP A 1 281 ? 35.746 -4.800  15.609  1.00 36.31 ?  271 ASP A OD2 1 
ATOM   2009 N N   . THR A 1 282 ? 40.279 -8.515  14.449  1.00 27.72 ?  272 THR A N   1 
ATOM   2010 C CA  . THR A 1 282 ? 40.888 -9.588  13.674  1.00 32.03 ?  272 THR A CA  1 
ATOM   2011 C C   . THR A 1 282 ? 40.695 -10.922 14.385  1.00 29.00 ?  272 THR A C   1 
ATOM   2012 O O   . THR A 1 282 ? 40.620 -10.998 15.621  1.00 28.04 ?  272 THR A O   1 
ATOM   2013 C CB  . THR A 1 282 ? 42.360 -9.240  13.435  1.00 22.16 ?  272 THR A CB  1 
ATOM   2014 O OG1 . THR A 1 282 ? 42.387 -8.237  12.406  1.00 30.69 ?  272 THR A OG1 1 
ATOM   2015 C CG2 . THR A 1 282 ? 43.208 -10.425 13.004  1.00 23.37 ?  272 THR A CG2 1 
ATOM   2016 N N   . VAL A 1 283 ? 40.517 -11.969 13.599  1.00 21.26 ?  273 VAL A N   1 
ATOM   2017 C CA  . VAL A 1 283 ? 40.371 -13.321 14.139  1.00 21.34 ?  273 VAL A CA  1 
ATOM   2018 C C   . VAL A 1 283 ? 41.545 -14.165 13.667  1.00 22.83 ?  273 VAL A C   1 
ATOM   2019 O O   . VAL A 1 283 ? 41.808 -14.263 12.457  1.00 23.47 ?  273 VAL A O   1 
ATOM   2020 C CB  . VAL A 1 283 ? 39.033 -13.971 13.732  1.00 24.12 ?  273 VAL A CB  1 
ATOM   2021 C CG1 . VAL A 1 283 ? 38.946 -15.429 14.232  1.00 26.11 ?  273 VAL A CG1 1 
ATOM   2022 C CG2 . VAL A 1 283 ? 37.855 -13.168 14.297  1.00 29.55 ?  273 VAL A CG2 1 
ATOM   2023 N N   . ILE A 1 284 ? 42.233 -14.790 14.620  1.00 20.63 ?  274 ILE A N   1 
ATOM   2024 C CA  . ILE A 1 284 ? 43.318 -15.718 14.340  1.00 26.69 ?  274 ILE A CA  1 
ATOM   2025 C C   . ILE A 1 284 ? 42.829 -17.127 14.671  1.00 27.28 ?  274 ILE A C   1 
ATOM   2026 O O   . ILE A 1 284 ? 42.517 -17.434 15.830  1.00 24.25 ?  274 ILE A O   1 
ATOM   2027 C CB  . ILE A 1 284 ? 44.593 -15.373 15.128  1.00 29.84 ?  274 ILE A CB  1 
ATOM   2028 C CG1 . ILE A 1 284 ? 44.936 -13.884 15.051  1.00 28.38 ?  274 ILE A CG1 1 
ATOM   2029 C CG2 . ILE A 1 284 ? 45.769 -16.218 14.619  1.00 25.34 ?  274 ILE A CG2 1 
ATOM   2030 C CD1 . ILE A 1 284 ? 45.288 -13.393 13.642  1.00 30.83 ?  274 ILE A CD1 1 
ATOM   2031 N N   . GLU A 1 285 ? 42.770 -17.988 13.660  1.00 23.35 ?  275 GLU A N   1 
ATOM   2032 C CA  . GLU A 1 285 ? 42.336 -19.372 13.852  1.00 25.87 ?  275 GLU A CA  1 
ATOM   2033 C C   . GLU A 1 285 ? 43.481 -20.259 14.334  1.00 27.68 ?  275 GLU A C   1 
ATOM   2034 O O   . GLU A 1 285 ? 44.643 -19.856 14.291  1.00 24.19 ?  275 GLU A O   1 
ATOM   2035 C CB  . GLU A 1 285 ? 41.724 -19.905 12.558  1.00 31.02 ?  275 GLU A CB  1 
ATOM   2036 C CG  . GLU A 1 285 ? 40.593 -19.057 12.011  1.00 32.94 ?  275 GLU A CG  1 
ATOM   2037 C CD  . GLU A 1 285 ? 39.739 -19.813 11.028  1.00 37.53 ?  275 GLU A CD  1 
ATOM   2038 O OE1 . GLU A 1 285 ? 40.277 -20.714 10.320  1.00 33.38 ?  275 GLU A OE1 1 
ATOM   2039 O OE2 . GLU A 1 285 ? 38.544 -19.459 10.910  1.00 39.14 -1 275 GLU A OE2 1 
ATOM   2040 N N   . PRO A 1 286 ? 43.178 -21.491 14.782  1.00 25.04 ?  276 PRO A N   1 
ATOM   2041 C CA  . PRO A 1 286 ? 44.211 -22.330 15.406  1.00 27.43 ?  276 PRO A CA  1 
ATOM   2042 C C   . PRO A 1 286 ? 45.361 -22.667 14.473  1.00 24.34 ?  276 PRO A C   1 
ATOM   2043 O O   . PRO A 1 286 ? 45.199 -22.783 13.254  1.00 25.04 ?  276 PRO A O   1 
ATOM   2044 C CB  . PRO A 1 286 ? 43.445 -23.607 15.793  1.00 27.92 ?  276 PRO A CB  1 
ATOM   2045 C CG  . PRO A 1 286 ? 42.046 -23.163 15.960  1.00 33.84 ?  276 PRO A CG  1 
ATOM   2046 C CD  . PRO A 1 286 ? 41.843 -22.125 14.894  1.00 28.35 ?  276 PRO A CD  1 
ATOM   2047 N N   . GLY A 1 287 ? 46.537 -22.833 15.072  1.00 27.27 ?  277 GLY A N   1 
ATOM   2048 C CA  . GLY A 1 287 ? 47.702 -23.298 14.363  1.00 26.06 ?  277 GLY A CA  1 
ATOM   2049 C C   . GLY A 1 287 ? 48.424 -22.234 13.577  1.00 27.60 ?  277 GLY A C   1 
ATOM   2050 O O   . GLY A 1 287 ? 49.499 -22.511 13.038  1.00 26.74 ?  277 GLY A O   1 
ATOM   2051 N N   . VAL A 1 288 ? 47.875 -21.024 13.510  1.00 24.06 ?  278 VAL A N   1 
ATOM   2052 C CA  . VAL A 1 288 ? 48.488 -19.956 12.734  1.00 21.91 ?  278 VAL A CA  1 
ATOM   2053 C C   . VAL A 1 288 ? 49.842 -19.551 13.316  1.00 28.71 ?  278 VAL A C   1 
ATOM   2054 O O   . VAL A 1 288 ? 50.022 -19.396 14.545  1.00 24.91 ?  278 VAL A O   1 
ATOM   2055 C CB  . VAL A 1 288 ? 47.508 -18.774 12.671  1.00 24.73 ?  278 VAL A CB  1 
ATOM   2056 C CG1 . VAL A 1 288 ? 48.200 -17.510 12.182  1.00 23.22 ?  278 VAL A CG1 1 
ATOM   2057 C CG2 . VAL A 1 288 ? 46.315 -19.137 11.772  1.00 25.81 ?  278 VAL A CG2 1 
ATOM   2058 N N   A ARG A 1 289 ? 50.818 -19.387 12.428  0.49 25.42 ?  279 ARG A N   1 
ATOM   2059 N N   B ARG A 1 289 ? 50.793 -19.331 12.419  0.51 26.39 ?  279 ARG A N   1 
ATOM   2060 C CA  A ARG A 1 289 ? 52.162 -18.950 12.795  0.49 27.29 ?  279 ARG A CA  1 
ATOM   2061 C CA  B ARG A 1 289 ? 52.158 -18.956 12.765  0.51 27.72 ?  279 ARG A CA  1 
ATOM   2062 C C   A ARG A 1 289 ? 52.467 -17.660 12.055  0.49 27.14 ?  279 ARG A C   1 
ATOM   2063 C C   B ARG A 1 289 ? 52.497 -17.661 12.044  0.51 26.89 ?  279 ARG A C   1 
ATOM   2064 O O   A ARG A 1 289 ? 52.473 -17.640 10.819  0.49 24.81 ?  279 ARG A O   1 
ATOM   2065 O O   B ARG A 1 289 ? 52.542 -17.636 10.809  0.51 26.21 ?  279 ARG A O   1 
ATOM   2066 C CB  A ARG A 1 289 ? 53.211 -20.015 12.462  0.49 26.17 ?  279 ARG A CB  1 
ATOM   2067 C CB  B ARG A 1 289 ? 53.126 -20.074 12.379  0.51 26.04 ?  279 ARG A CB  1 
ATOM   2068 C CG  A ARG A 1 289 ? 54.379 -20.070 13.440  0.49 35.42 ?  279 ARG A CG  1 
ATOM   2069 C CG  B ARG A 1 289 ? 54.354 -20.173 13.241  0.51 35.43 ?  279 ARG A CG  1 
ATOM   2070 C CD  A ARG A 1 289 ? 55.387 -21.177 13.072  0.49 34.32 ?  279 ARG A CD  1 
ATOM   2071 C CD  B ARG A 1 289 ? 54.613 -21.601 13.749  0.51 34.96 ?  279 ARG A CD  1 
ATOM   2072 N NE  A ARG A 1 289 ? 56.766 -20.824 13.412  0.49 41.92 ?  279 ARG A NE  1 
ATOM   2073 N NE  B ARG A 1 289 ? 56.042 -21.863 13.806  0.51 39.87 ?  279 ARG A NE  1 
ATOM   2074 C CZ  A ARG A 1 289 ? 57.209 -20.638 14.650  0.49 37.73 ?  279 ARG A CZ  1 
ATOM   2075 C CZ  B ARG A 1 289 ? 56.865 -21.883 12.763  0.51 38.72 ?  279 ARG A CZ  1 
ATOM   2076 N NH1 A ARG A 1 289 ? 56.426 -20.831 15.698  0.49 37.14 ?  279 ARG A NH1 1 
ATOM   2077 N NH1 B ARG A 1 289 ? 56.412 -21.988 11.518  0.51 29.79 ?  279 ARG A NH1 1 
ATOM   2078 N NH2 A ARG A 1 289 ? 58.476 -20.265 14.841  0.49 31.02 ?  279 ARG A NH2 1 
ATOM   2079 N NH2 B ARG A 1 289 ? 58.179 -21.835 12.978  0.51 33.59 ?  279 ARG A NH2 1 
ATOM   2080 N N   . ILE A 1 290 ? 52.714 -16.588 12.808  1.00 22.34 ?  280 ILE A N   1 
ATOM   2081 C CA  . ILE A 1 290 ? 52.947 -15.254 12.246  1.00 24.85 ?  280 ILE A CA  1 
ATOM   2082 C C   . ILE A 1 290 ? 54.229 -14.683 12.834  1.00 28.20 ?  280 ILE A C   1 
ATOM   2083 O O   . ILE A 1 290 ? 54.300 -14.451 14.045  1.00 23.81 ?  280 ILE A O   1 
ATOM   2084 C CB  . ILE A 1 290 ? 51.776 -14.297 12.530  1.00 19.71 ?  280 ILE A CB  1 
ATOM   2085 C CG1 . ILE A 1 290 ? 50.466 -14.880 12.001  1.00 24.70 ?  280 ILE A CG1 1 
ATOM   2086 C CG2 . ILE A 1 290 ? 52.027 -12.979 11.817  1.00 22.75 ?  280 ILE A CG2 1 
ATOM   2087 C CD1 . ILE A 1 290 ? 49.216 -14.133 12.487  1.00 30.73 ?  280 ILE A CD1 1 
ATOM   2088 N N   . ASN A 1 291 ? 55.217 -14.386 11.980  1.00 24.78 ?  281 ASN A N   1 
ATOM   2089 C CA  . ASN A 1 291 ? 56.546 -14.045 12.486  1.00 31.80 ?  281 ASN A CA  1 
ATOM   2090 C C   . ASN A 1 291 ? 57.182 -12.956 11.625  1.00 30.34 ?  281 ASN A C   1 
ATOM   2091 O O   . ASN A 1 291 ? 56.622 -12.525 10.604  1.00 30.67 ?  281 ASN A O   1 
ATOM   2092 C CB  . ASN A 1 291 ? 57.426 -15.300 12.569  1.00 32.64 ?  281 ASN A CB  1 
ATOM   2093 C CG  . ASN A 1 291 ? 57.097 -16.147 13.788  1.00 44.23 ?  281 ASN A CG  1 
ATOM   2094 O OD1 . ASN A 1 291 ? 57.202 -15.681 14.921  1.00 35.00 ?  281 ASN A OD1 1 
ATOM   2095 N ND2 . ASN A 1 291 ? 56.649 -17.376 13.559  1.00 40.90 ?  281 ASN A ND2 1 
ATOM   2096 N N   . GLY A 1 292 ? 58.369 -12.507 12.054  1.00 36.13 ?  282 GLY A N   1 
ATOM   2097 C CA  . GLY A 1 292 ? 59.045 -11.398 11.371  1.00 34.43 ?  282 GLY A CA  1 
ATOM   2098 C C   . GLY A 1 292 ? 58.321 -10.097 11.682  1.00 33.98 ?  282 GLY A C   1 
ATOM   2099 O O   . GLY A 1 292 ? 57.510 -10.005 12.615  1.00 31.74 ?  282 GLY A O   1 
ATOM   2100 N N   . ARG A 1 293 ? 58.624 -9.076  10.878  1.00 31.70 ?  283 ARG A N   1 
ATOM   2101 C CA  . ARG A 1 293 ? 57.982 -7.766  10.987  1.00 30.68 ?  283 ARG A CA  1 
ATOM   2102 C C   . ARG A 1 293 ? 56.712 -7.800  10.144  1.00 34.76 ?  283 ARG A C   1 
ATOM   2103 O O   . ARG A 1 293 ? 56.733 -7.500  8.948   1.00 35.68 ?  283 ARG A O   1 
ATOM   2104 C CB  . ARG A 1 293 ? 58.935 -6.662  10.526  1.00 34.95 ?  283 ARG A CB  1 
ATOM   2105 N N   . THR A 1 294 ? 55.598 -8.204  10.757  1.00 32.81 ?  284 THR A N   1 
ATOM   2106 C CA  . THR A 1 294 ? 54.324 -8.337  10.058  1.00 32.54 ?  284 THR A CA  1 
ATOM   2107 C C   . THR A 1 294 ? 53.312 -7.355  10.624  1.00 30.90 ?  284 THR A C   1 
ATOM   2108 O O   . THR A 1 294 ? 53.231 -7.164  11.843  1.00 27.13 ?  284 THR A O   1 
ATOM   2109 C CB  . THR A 1 294 ? 53.781 -9.759  10.164  1.00 28.23 ?  284 THR A CB  1 
ATOM   2110 O OG1 . THR A 1 294 ? 54.585 -10.621 9.363   1.00 32.91 ?  284 THR A OG1 1 
ATOM   2111 C CG2 . THR A 1 294 ? 52.336 -9.843  9.682   1.00 28.36 ?  284 THR A CG2 1 
ATOM   2112 N N   . GLU A 1 295 ? 52.536 -6.738  9.732   1.00 23.47 ?  285 GLU A N   1 
ATOM   2113 C CA  . GLU A 1 295 ? 51.463 -5.813  10.103  1.00 25.86 ?  285 GLU A CA  1 
ATOM   2114 C C   . GLU A 1 295 ? 50.145 -6.351  9.572   1.00 30.06 ?  285 GLU A C   1 
ATOM   2115 O O   . GLU A 1 295 ? 49.986 -6.505  8.356   1.00 30.75 ?  285 GLU A O   1 
ATOM   2116 C CB  . GLU A 1 295 ? 51.706 -4.409  9.531   1.00 26.19 ?  285 GLU A CB  1 
ATOM   2117 C CG  . GLU A 1 295 ? 52.850 -3.656  10.185  1.00 45.69 ?  285 GLU A CG  1 
ATOM   2118 C CD  . GLU A 1 295 ? 53.589 -2.769  9.191   1.00 67.93 ?  285 GLU A CD  1 
ATOM   2119 O OE1 . GLU A 1 295 ? 52.983 -1.775  8.719   1.00 64.82 ?  285 GLU A OE1 1 
ATOM   2120 O OE2 . GLU A 1 295 ? 54.763 -3.074  8.869   1.00 71.02 ?  285 GLU A OE2 1 
ATOM   2121 N N   . ILE A 1 296 ? 49.207 -6.631  10.470  1.00 24.10 ?  286 ILE A N   1 
ATOM   2122 C CA  . ILE A 1 296 ? 47.874 -7.104  10.100  1.00 26.42 ?  286 ILE A CA  1 
ATOM   2123 C C   . ILE A 1 296 ? 46.842 -6.035  10.471  1.00 28.60 ?  286 ILE A C   1 
ATOM   2124 O O   . ILE A 1 296 ? 46.840 -5.521  11.597  1.00 26.07 ?  286 ILE A O   1 
ATOM   2125 C CB  . ILE A 1 296 ? 47.574 -8.465  10.755  1.00 24.00 ?  286 ILE A CB  1 
ATOM   2126 C CG1 . ILE A 1 296 ? 48.485 -9.558  10.175  1.00 28.52 ?  286 ILE A CG1 1 
ATOM   2127 C CG2 . ILE A 1 296 ? 46.126 -8.897  10.561  1.00 26.03 ?  286 ILE A CG2 1 
ATOM   2128 C CD1 . ILE A 1 296 ? 48.790 -10.620 11.117  1.00 30.74 ?  286 ILE A CD1 1 
ATOM   2129 N N   . GLY A 1 297 ? 45.978 -5.684  9.524   1.00 22.34 ?  287 GLY A N   1 
ATOM   2130 C CA  . GLY A 1 297 ? 44.965 -4.650  9.746   1.00 23.50 ?  287 GLY A CA  1 
ATOM   2131 C C   . GLY A 1 297 ? 43.777 -5.109  10.579  1.00 28.30 ?  287 GLY A C   1 
ATOM   2132 O O   . GLY A 1 297 ? 43.747 -6.207  11.133  1.00 29.72 ?  287 GLY A O   1 
ATOM   2133 N N   . GLU A 1 298 ? 42.780 -4.230  10.684  1.00 23.91 ?  288 GLU A N   1 
ATOM   2134 C CA  . GLU A 1 298 ? 41.544 -4.586  11.375  1.00 27.59 ?  288 GLU A CA  1 
ATOM   2135 C C   . GLU A 1 298 ? 40.683 -5.514  10.525  1.00 26.10 ?  288 GLU A C   1 
ATOM   2136 O O   . GLU A 1 298 ? 40.791 -5.552  9.295   1.00 28.18 ?  288 GLU A O   1 
ATOM   2137 C CB  . GLU A 1 298 ? 40.730 -3.336  11.713  1.00 31.31 ?  288 GLU A CB  1 
ATOM   2138 C CG  . GLU A 1 298 ? 41.503 -2.352  12.563  1.00 36.94 ?  288 GLU A CG  1 
ATOM   2139 C CD  . GLU A 1 298 ? 40.641 -1.202  13.027  1.00 38.54 ?  288 GLU A CD  1 
ATOM   2140 O OE1 . GLU A 1 298 ? 39.718 -0.828  12.264  1.00 37.71 ?  288 GLU A OE1 1 
ATOM   2141 O OE2 . GLU A 1 298 ? 40.896 -0.671  14.134  1.00 33.51 ?  288 GLU A OE2 1 
ATOM   2142 N N   . ASP A 1 299 ? 39.819 -6.271  11.206  1.00 21.74 ?  289 ASP A N   1 
ATOM   2143 C CA  . ASP A 1 299 ? 38.782 -7.101  10.569  1.00 27.78 ?  289 ASP A CA  1 
ATOM   2144 C C   . ASP A 1 299 ? 39.348 -8.168  9.622   1.00 25.86 ?  289 ASP A C   1 
ATOM   2145 O O   . ASP A 1 299 ? 38.658 -8.625  8.708   1.00 27.93 ?  289 ASP A O   1 
ATOM   2146 C CB  . ASP A 1 299 ? 37.785 -6.225  9.816   1.00 35.07 ?  289 ASP A CB  1 
ATOM   2147 C CG  . ASP A 1 299 ? 37.047 -5.282  10.734  1.00 41.89 ?  289 ASP A CG  1 
ATOM   2148 O OD1 . ASP A 1 299 ? 36.606 -5.727  11.814  1.00 41.60 ?  289 ASP A OD1 1 
ATOM   2149 O OD2 . ASP A 1 299 ? 36.964 -4.094  10.389  1.00 42.94 ?  289 ASP A OD2 1 
ATOM   2150 N N   . VAL A 1 300 ? 40.551 -8.596  9.851   1.00 24.53 ?  290 VAL A N   1 
ATOM   2151 C CA  . VAL A 1 300 ? 41.188 -9.666  9.086   1.00 23.66 ?  290 VAL A CA  1 
ATOM   2152 C C   . VAL A 1 300 ? 40.826 -11.014 9.683   1.00 26.98 ?  290 VAL A C   1 
ATOM   2153 O O   . VAL A 1 300 ? 40.600 -11.133 10.893  1.00 21.73 ?  290 VAL A O   1 
ATOM   2154 C CB  . VAL A 1 300 ? 42.711 -9.420  9.062   1.00 24.57 ?  290 VAL A CB  1 
ATOM   2155 C CG1 . VAL A 1 300 ? 43.492 -10.611 8.491   1.00 25.55 ?  290 VAL A CG1 1 
ATOM   2156 C CG2 . VAL A 1 300 ? 42.999 -8.204  8.224   1.00 23.82 ?  290 VAL A CG2 1 
ATOM   2157 N N   . VAL A 1 301 ? 40.712 -12.039 8.834   1.00 20.85 ?  291 VAL A N   1 
ATOM   2158 C CA  . VAL A 1 301 ? 40.670 -13.432 9.297   1.00 22.70 ?  291 VAL A CA  1 
ATOM   2159 C C   . VAL A 1 301 ? 41.922 -14.142 8.809   1.00 25.29 ?  291 VAL A C   1 
ATOM   2160 O O   . VAL A 1 301 ? 42.165 -14.219 7.595   1.00 27.08 ?  291 VAL A O   1 
ATOM   2161 C CB  . VAL A 1 301 ? 39.412 -14.171 8.814   1.00 27.43 ?  291 VAL A CB  1 
ATOM   2162 C CG1 . VAL A 1 301 ? 39.511 -15.662 9.188   1.00 29.35 ?  291 VAL A CG1 1 
ATOM   2163 C CG2 . VAL A 1 301 ? 38.177 -13.565 9.447   1.00 27.44 ?  291 VAL A CG2 1 
ATOM   2164 N N   . ILE A 1 302 ? 42.727 -14.663 9.735   1.00 19.92 ?  292 ILE A N   1 
ATOM   2165 C CA  . ILE A 1 302 ? 43.839 -15.534 9.359   1.00 23.51 ?  292 ILE A CA  1 
ATOM   2166 C C   . ILE A 1 302 ? 43.393 -16.960 9.666   1.00 29.06 ?  292 ILE A C   1 
ATOM   2167 O O   . ILE A 1 302 ? 43.220 -17.334 10.833  1.00 25.29 ?  292 ILE A O   1 
ATOM   2168 C CB  . ILE A 1 302 ? 45.150 -15.204 10.083  1.00 24.94 ?  292 ILE A CB  1 
ATOM   2169 C CG1 . ILE A 1 302 ? 45.537 -13.714 9.944   1.00 26.45 ?  292 ILE A CG1 1 
ATOM   2170 C CG2 . ILE A 1 302 ? 46.264 -16.109 9.528   1.00 19.66 ?  292 ILE A CG2 1 
ATOM   2171 C CD1 . ILE A 1 302 ? 45.733 -13.259 8.476   1.00 24.06 ?  292 ILE A CD1 1 
ATOM   2172 N N   . GLY A 1 303 ? 43.200 -17.760 8.620   1.00 23.10 ?  293 GLY A N   1 
ATOM   2173 C CA  . GLY A 1 303 ? 42.624 -19.079 8.794   1.00 22.85 ?  293 GLY A CA  1 
ATOM   2174 C C   . GLY A 1 303 ? 43.644 -20.107 9.223   1.00 27.91 ?  293 GLY A C   1 
ATOM   2175 O O   . GLY A 1 303 ? 44.848 -19.923 9.045   1.00 24.31 ?  293 GLY A O   1 
ATOM   2176 N N   . GLN A 1 304 ? 43.110 -21.221 9.729   1.00 23.57 ?  294 GLN A N   1 
ATOM   2177 C CA  . GLN A 1 304 ? 43.876 -22.247 10.417  1.00 27.87 ?  294 GLN A CA  1 
ATOM   2178 C C   . GLN A 1 304 ? 45.110 -22.713 9.639   1.00 22.79 ?  294 GLN A C   1 
ATOM   2179 O O   . GLN A 1 304 ? 45.095 -22.840 8.409   1.00 25.20 ?  294 GLN A O   1 
ATOM   2180 C CB  . GLN A 1 304 ? 42.944 -23.435 10.715  1.00 26.20 ?  294 GLN A CB  1 
ATOM   2181 C CG  . GLN A 1 304 ? 42.292 -24.075 9.485   1.00 27.15 ?  294 GLN A CG  1 
ATOM   2182 C CD  . GLN A 1 304 ? 41.584 -25.378 9.842   1.00 30.77 ?  294 GLN A CD  1 
ATOM   2183 O OE1 . GLN A 1 304 ? 40.808 -25.413 10.781  1.00 33.31 ?  294 GLN A OE1 1 
ATOM   2184 N NE2 . GLN A 1 304 ? 41.870 -26.451 9.104   1.00 33.07 ?  294 GLN A NE2 1 
ATOM   2185 N N   . TYR A 1 305 ? 46.197 -22.900 10.381  1.00 26.51 ?  295 TYR A N   1 
ATOM   2186 C CA  . TYR A 1 305 ? 47.450 -23.517 9.911   1.00 25.70 ?  295 TYR A CA  1 
ATOM   2187 C C   . TYR A 1 305 ? 48.108 -22.704 8.793   1.00 29.45 ?  295 TYR A C   1 
ATOM   2188 O O   . TYR A 1 305 ? 48.882 -23.240 8.004   1.00 26.91 ?  295 TYR A O   1 
ATOM   2189 C CB  . TYR A 1 305 ? 47.245 -25.005 9.524   1.00 27.22 ?  295 TYR A CB  1 
ATOM   2190 C CG  . TYR A 1 305 ? 46.449 -25.638 10.644  1.00 26.00 ?  295 TYR A CG  1 
ATOM   2191 C CD1 . TYR A 1 305 ? 46.998 -25.695 11.923  1.00 24.42 ?  295 TYR A CD1 1 
ATOM   2192 C CD2 . TYR A 1 305 ? 45.148 -26.110 10.450  1.00 26.06 ?  295 TYR A CD2 1 
ATOM   2193 C CE1 . TYR A 1 305 ? 46.274 -26.174 12.999  1.00 28.92 ?  295 TYR A CE1 1 
ATOM   2194 C CE2 . TYR A 1 305 ? 44.418 -26.621 11.516  1.00 24.01 ?  295 TYR A CE2 1 
ATOM   2195 C CZ  . TYR A 1 305 ? 44.989 -26.640 12.790  1.00 27.70 ?  295 TYR A CZ  1 
ATOM   2196 O OH  . TYR A 1 305 ? 44.290 -27.109 13.886  1.00 27.39 ?  295 TYR A OH  1 
ATOM   2197 N N   . SER A 1 306 ? 47.859 -21.397 8.762   1.00 23.32 ?  296 SER A N   1 
ATOM   2198 C CA  . SER A 1 306 ? 48.603 -20.516 7.871   1.00 24.96 ?  296 SER A CA  1 
ATOM   2199 C C   . SER A 1 306 ? 49.974 -20.172 8.440   1.00 28.16 ?  296 SER A C   1 
ATOM   2200 O O   . SER A 1 306 ? 50.202 -20.204 9.651   1.00 27.06 ?  296 SER A O   1 
ATOM   2201 C CB  . SER A 1 306 ? 47.848 -19.220 7.626   1.00 24.57 ?  296 SER A CB  1 
ATOM   2202 O OG  . SER A 1 306 ? 46.703 -19.463 6.832   1.00 25.43 ?  296 SER A OG  1 
ATOM   2203 N N   . GLU A 1 307 ? 50.883 -19.784 7.555   1.00 20.28 ?  297 GLU A N   1 
ATOM   2204 C CA  . GLU A 1 307 ? 52.184 -19.272 7.976   1.00 22.57 ?  297 GLU A CA  1 
ATOM   2205 C C   . GLU A 1 307 ? 52.438 -17.945 7.282   1.00 22.84 ?  297 GLU A C   1 
ATOM   2206 O O   . GLU A 1 307 ? 52.383 -17.864 6.051   1.00 23.30 ?  297 GLU A O   1 
ATOM   2207 C CB  . GLU A 1 307 ? 53.317 -20.272 7.679   1.00 22.64 ?  297 GLU A CB  1 
ATOM   2208 C CG  . GLU A 1 307 ? 54.651 -19.792 8.296   1.00 28.13 ?  297 GLU A CG  1 
ATOM   2209 C CD  . GLU A 1 307 ? 55.877 -20.682 8.046   1.00 32.81 ?  297 GLU A CD  1 
ATOM   2210 O OE1 . GLU A 1 307 ? 55.763 -21.802 7.495   1.00 32.49 ?  297 GLU A OE1 1 
ATOM   2211 O OE2 . GLU A 1 307 ? 56.995 -20.227 8.394   1.00 47.30 ?  297 GLU A OE2 1 
ATOM   2212 N N   . ILE A 1 308 ? 52.693 -16.892 8.056   1.00 21.15 ?  298 ILE A N   1 
ATOM   2213 C CA  . ILE A 1 308 ? 52.872 -15.556 7.483   1.00 19.84 ?  298 ILE A CA  1 
ATOM   2214 C C   . ILE A 1 308 ? 54.131 -14.946 8.076   1.00 24.64 ?  298 ILE A C   1 
ATOM   2215 O O   . ILE A 1 308 ? 54.215 -14.777 9.296   1.00 24.64 ?  298 ILE A O   1 
ATOM   2216 C CB  . ILE A 1 308 ? 51.671 -14.642 7.764   1.00 21.37 ?  298 ILE A CB  1 
ATOM   2217 C CG1 . ILE A 1 308 ? 50.391 -15.224 7.146   1.00 27.25 ?  298 ILE A CG1 1 
ATOM   2218 C CG2 . ILE A 1 308 ? 51.962 -13.261 7.193   1.00 21.81 ?  298 ILE A CG2 1 
ATOM   2219 C CD1 . ILE A 1 308 ? 49.127 -14.580 7.632   1.00 34.03 ?  298 ILE A CD1 1 
ATOM   2220 N N   . ASN A 1 309 ? 55.079 -14.545 7.221   1.00 25.31 ?  299 ASN A N   1 
ATOM   2221 C CA  . ASN A 1 309 ? 56.333 -13.981 7.703   1.00 28.80 ?  299 ASN A CA  1 
ATOM   2222 C C   . ASN A 1 309 ? 56.620 -12.683 6.962   1.00 27.76 ?  299 ASN A C   1 
ATOM   2223 O O   . ASN A 1 309 ? 56.477 -12.623 5.738   1.00 27.97 ?  299 ASN A O   1 
ATOM   2224 C CB  . ASN A 1 309 ? 57.499 -14.964 7.512   1.00 25.80 ?  299 ASN A CB  1 
ATOM   2225 C CG  . ASN A 1 309 ? 57.351 -16.244 8.340   1.00 31.86 ?  299 ASN A CG  1 
ATOM   2226 O OD1 . ASN A 1 309 ? 57.113 -16.206 9.550   1.00 33.74 ?  299 ASN A OD1 1 
ATOM   2227 N ND2 . ASN A 1 309 ? 57.449 -17.388 7.671   1.00 29.91 ?  299 ASN A ND2 1 
ATOM   2228 N N   . ASN A 1 310 ? 56.996 -11.638 7.702   1.00 28.11 ?  300 ASN A N   1 
ATOM   2229 C CA  . ASN A 1 310 ? 57.461 -10.371 7.101   1.00 24.62 ?  300 ASN A CA  1 
ATOM   2230 C C   . ASN A 1 310 ? 56.505 -9.830  6.024   1.00 27.19 ?  300 ASN A C   1 
ATOM   2231 O O   . ASN A 1 310 ? 56.907 -9.500  4.905   1.00 29.73 ?  300 ASN A O   1 
ATOM   2232 C CB  . ASN A 1 310 ? 58.860 -10.559 6.517   1.00 26.13 ?  300 ASN A CB  1 
ATOM   2233 C CG  . ASN A 1 310 ? 59.859 -10.997 7.557   1.00 36.40 ?  300 ASN A CG  1 
ATOM   2234 O OD1 . ASN A 1 310 ? 60.151 -10.251 8.494   1.00 34.50 ?  300 ASN A OD1 1 
ATOM   2235 N ND2 . ASN A 1 310 ? 60.403 -12.210 7.399   1.00 36.02 ?  300 ASN A ND2 1 
ATOM   2236 N N   . SER A 1 311 ? 55.228 -9.722  6.357   1.00 27.98 ?  301 SER A N   1 
ATOM   2237 C CA  . SER A 1 311 ? 54.231 -9.351  5.357   1.00 26.31 ?  301 SER A CA  1 
ATOM   2238 C C   . SER A 1 311 ? 53.291 -8.274  5.878   1.00 28.16 ?  301 SER A C   1 
ATOM   2239 O O   . SER A 1 311 ? 53.216 -8.000  7.077   1.00 26.16 ?  301 SER A O   1 
ATOM   2240 C CB  . SER A 1 311 ? 53.441 -10.564 4.883   1.00 28.57 ?  301 SER A CB  1 
ATOM   2241 O OG  . SER A 1 311 ? 54.317 -11.510 4.304   1.00 29.29 ?  301 SER A OG  1 
ATOM   2242 N N   . THR A 1 312 ? 52.552 -7.668  4.950   1.00 27.26 ?  302 THR A N   1 
ATOM   2243 C CA  . THR A 1 312 ? 51.520 -6.690  5.269   1.00 27.94 ?  302 THR A CA  1 
ATOM   2244 C C   . THR A 1 312 ? 50.173 -7.196  4.770   1.00 34.63 ?  302 THR A C   1 
ATOM   2245 O O   . THR A 1 312 ? 50.035 -7.549  3.593   1.00 27.80 ?  302 THR A O   1 
ATOM   2246 C CB  . THR A 1 312 ? 51.869 -5.329  4.645   1.00 30.84 ?  302 THR A CB  1 
ATOM   2247 O OG1 . THR A 1 312 ? 53.052 -4.825  5.278   1.00 38.75 ?  302 THR A OG1 1 
ATOM   2248 C CG2 . THR A 1 312 ? 50.756 -4.334  4.823   1.00 35.70 ?  302 THR A CG2 1 
ATOM   2249 N N   . ILE A 1 313 ? 49.186 -7.240  5.663   1.00 26.56 ?  303 ILE A N   1 
ATOM   2250 C CA  . ILE A 1 313 ? 47.835 -7.698  5.337   1.00 27.85 ?  303 ILE A CA  1 
ATOM   2251 C C   . ILE A 1 313 ? 46.855 -6.596  5.716   1.00 34.06 ?  303 ILE A C   1 
ATOM   2252 O O   . ILE A 1 313 ? 46.724 -6.248  6.899   1.00 29.36 ?  303 ILE A O   1 
ATOM   2253 C CB  . ILE A 1 313 ? 47.497 -8.999  6.069   1.00 27.63 ?  303 ILE A CB  1 
ATOM   2254 C CG1 . ILE A 1 313 ? 48.539 -10.059 5.724   1.00 31.34 ?  303 ILE A CG1 1 
ATOM   2255 C CG2 . ILE A 1 313 ? 46.096 -9.474  5.707   1.00 27.29 ?  303 ILE A CG2 1 
ATOM   2256 C CD1 . ILE A 1 313 ? 48.526 -11.189 6.652   1.00 44.84 ?  303 ILE A CD1 1 
ATOM   2257 N N   . GLU A 1 314 ? 46.152 -6.058  4.728   1.00 26.75 ?  304 GLU A N   1 
ATOM   2258 C CA  . GLU A 1 314 ? 45.294 -4.917  5.017   1.00 30.11 ?  304 GLU A CA  1 
ATOM   2259 C C   . GLU A 1 314 ? 43.934 -5.343  5.535   1.00 29.23 ?  304 GLU A C   1 
ATOM   2260 O O   . GLU A 1 314 ? 43.597 -6.533  5.611   1.00 26.03 ?  304 GLU A O   1 
ATOM   2261 C CB  . GLU A 1 314 ? 45.151 -4.033  3.781   1.00 30.84 ?  304 GLU A CB  1 
ATOM   2262 C CG  . GLU A 1 314 ? 46.499 -3.741  3.159   1.00 41.05 ?  304 GLU A CG  1 
ATOM   2263 C CD  . GLU A 1 314 ? 46.687 -2.297  2.882   1.00 52.35 ?  304 GLU A CD  1 
ATOM   2264 O OE1 . GLU A 1 314 ? 46.545 -1.488  3.832   1.00 61.99 ?  304 GLU A OE1 1 
ATOM   2265 O OE2 . GLU A 1 314 ? 46.975 -1.978  1.710   1.00 56.45 ?  304 GLU A OE2 1 
ATOM   2266 N N   . ASN A 1 315 ? 43.150 -4.336  5.914   1.00 27.77 ?  305 ASN A N   1 
ATOM   2267 C CA  . ASN A 1 315 ? 41.885 -4.575  6.595   1.00 25.54 ?  305 ASN A CA  1 
ATOM   2268 C C   . ASN A 1 315 ? 40.915 -5.414  5.762   1.00 28.32 ?  305 ASN A C   1 
ATOM   2269 O O   . ASN A 1 315 ? 40.822 -5.285  4.537   1.00 26.44 ?  305 ASN A O   1 
ATOM   2270 C CB  . ASN A 1 315 ? 41.241 -3.242  6.986   1.00 34.22 ?  305 ASN A CB  1 
ATOM   2271 C CG  . ASN A 1 315 ? 40.625 -2.539  5.812   1.00 49.43 ?  305 ASN A CG  1 
ATOM   2272 O OD1 . ASN A 1 315 ? 39.422 -2.656  5.557   1.00 55.73 ?  305 ASN A OD1 1 
ATOM   2273 N ND2 . ASN A 1 315 ? 41.446 -1.775  5.089   1.00 54.77 ?  305 ASN A ND2 1 
ATOM   2274 N N   . GLY A 1 316 ? 40.186 -6.292  6.439   1.00 24.04 ?  306 GLY A N   1 
ATOM   2275 C CA  . GLY A 1 316 ? 39.172 -7.106  5.785   1.00 26.96 ?  306 GLY A CA  1 
ATOM   2276 C C   . GLY A 1 316 ? 39.691 -8.293  4.990   1.00 26.11 ?  306 GLY A C   1 
ATOM   2277 O O   . GLY A 1 316 ? 38.885 -9.034  4.418   1.00 28.38 ?  306 GLY A O   1 
ATOM   2278 N N   . ALA A 1 317 ? 40.999 -8.498  4.923   1.00 21.18 ?  307 ALA A N   1 
ATOM   2279 C CA  . ALA A 1 317 ? 41.521 -9.607  4.137   1.00 24.72 ?  307 ALA A CA  1 
ATOM   2280 C C   . ALA A 1 317 ? 41.283 -10.933 4.844   1.00 27.57 ?  307 ALA A C   1 
ATOM   2281 O O   . ALA A 1 317 ? 41.062 -10.998 6.060   1.00 22.93 ?  307 ALA A O   1 
ATOM   2282 C CB  . ALA A 1 317 ? 43.020 -9.422  3.856   1.00 21.12 ?  307 ALA A CB  1 
ATOM   2283 N N   . CYS A 1 318 ? 41.300 -11.999 4.051   1.00 25.35 ?  308 CYS A N   1 
ATOM   2284 C CA  . CYS A 1 318 ? 41.105 -13.364 4.526   1.00 26.16 ?  308 CYS A CA  1 
ATOM   2285 C C   . CYS A 1 318 ? 42.223 -14.234 3.970   1.00 29.70 ?  308 CYS A C   1 
ATOM   2286 O O   . CYS A 1 318 ? 42.380 -14.335 2.746   1.00 29.18 ?  308 CYS A O   1 
ATOM   2287 C CB  . CYS A 1 318 ? 39.741 -13.904 4.085   1.00 28.56 ?  308 CYS A CB  1 
ATOM   2288 S SG  . CYS A 1 318 ? 39.507 -15.642 4.431   1.00 56.00 ?  308 CYS A SG  1 
ATOM   2289 N N   . ILE A 1 319 ? 42.999 -14.848 4.858   1.00 24.34 ?  309 ILE A N   1 
ATOM   2290 C CA  . ILE A 1 319 ? 44.106 -15.736 4.495   1.00 24.79 ?  309 ILE A CA  1 
ATOM   2291 C C   . ILE A 1 319 ? 43.761 -17.118 5.032   1.00 31.07 ?  309 ILE A C   1 
ATOM   2292 O O   . ILE A 1 319 ? 43.717 -17.309 6.252   1.00 32.66 ?  309 ILE A O   1 
ATOM   2293 C CB  . ILE A 1 319 ? 45.444 -15.282 5.087   1.00 28.69 ?  309 ILE A CB  1 
ATOM   2294 C CG1 . ILE A 1 319 ? 45.734 -13.803 4.801   1.00 33.67 ?  309 ILE A CG1 1 
ATOM   2295 C CG2 . ILE A 1 319 ? 46.584 -16.225 4.635   1.00 23.67 ?  309 ILE A CG2 1 
ATOM   2296 C CD1 . ILE A 1 319 ? 45.946 -13.469 3.349   1.00 25.30 ?  309 ILE A CD1 1 
ATOM   2297 N N   . GLN A 1 320 ? 43.559 -18.089 4.149   1.00 25.61 ?  310 GLN A N   1 
ATOM   2298 C CA  . GLN A 1 320 ? 43.168 -19.438 4.559   1.00 24.99 ?  310 GLN A CA  1 
ATOM   2299 C C   . GLN A 1 320 ? 44.271 -20.454 4.309   1.00 25.99 ?  310 GLN A C   1 
ATOM   2300 O O   . GLN A 1 320 ? 44.671 -20.641 3.158   1.00 25.87 ?  310 GLN A O   1 
ATOM   2301 C CB  . GLN A 1 320 ? 41.925 -19.903 3.819   1.00 27.79 ?  310 GLN A CB  1 
ATOM   2302 C CG  . GLN A 1 320 ? 41.069 -20.816 4.668   1.00 48.51 ?  310 GLN A CG  1 
ATOM   2303 C CD  . GLN A 1 320 ? 39.827 -21.291 3.939   1.00 42.01 ?  310 GLN A CD  1 
ATOM   2304 O OE1 . GLN A 1 320 ? 39.333 -22.396 4.198   1.00 39.93 ?  310 GLN A OE1 1 
ATOM   2305 N NE2 . GLN A 1 320 ? 39.323 -20.469 3.014   1.00 38.65 ?  310 GLN A NE2 1 
ATOM   2306 N N   . GLN A 1 321 ? 44.682 -21.186 5.365   1.00 29.82 ?  311 GLN A N   1 
ATOM   2307 C CA  . GLN A 1 321 ? 45.706 -22.249 5.289   1.00 22.75 ?  311 GLN A CA  1 
ATOM   2308 C C   . GLN A 1 321 ? 46.687 -22.054 4.127   1.00 24.43 ?  311 GLN A C   1 
ATOM   2309 O O   . GLN A 1 321 ? 46.680 -22.820 3.158   1.00 27.46 ?  311 GLN A O   1 
ATOM   2310 C CB  . GLN A 1 321 ? 45.034 -23.615 5.154   1.00 24.09 ?  311 GLN A CB  1 
ATOM   2311 C CG  . GLN A 1 321 ? 45.795 -24.779 5.754   1.00 35.02 ?  311 GLN A CG  1 
ATOM   2312 C CD  . GLN A 1 321 ? 44.855 -25.903 6.257   1.00 34.58 ?  311 GLN A CD  1 
ATOM   2313 O OE1 . GLN A 1 321 ? 43.647 -25.701 6.463   1.00 35.76 ?  311 GLN A OE1 1 
ATOM   2314 N NE2 . GLN A 1 321 ? 45.420 -27.055 6.492   1.00 26.57 ?  311 GLN A NE2 1 
ATOM   2315 N N   . SER A 1 322 ? 47.514 -21.016 4.207   1.00 24.95 ?  312 SER A N   1 
ATOM   2316 C CA  . SER A 1 322 ? 48.354 -20.566 3.114   1.00 22.14 ?  312 SER A CA  1 
ATOM   2317 C C   . SER A 1 322 ? 49.714 -20.206 3.671   1.00 21.69 ?  312 SER A C   1 
ATOM   2318 O O   . SER A 1 322 ? 49.891 -20.062 4.886   1.00 22.80 ?  312 SER A O   1 
ATOM   2319 C CB  . SER A 1 322 ? 47.740 -19.353 2.426   1.00 23.92 ?  312 SER A CB  1 
ATOM   2320 O OG  . SER A 1 322 ? 46.665 -19.758 1.627   1.00 26.60 ?  312 SER A OG  1 
ATOM   2321 N N   . VAL A 1 323 ? 50.678 -20.030 2.777   1.00 19.67 ?  313 VAL A N   1 
ATOM   2322 C CA  . VAL A 1 323 ? 52.033 -19.642 3.160   1.00 20.47 ?  313 VAL A CA  1 
ATOM   2323 C C   . VAL A 1 323 ? 52.346 -18.327 2.484   1.00 22.88 ?  313 VAL A C   1 
ATOM   2324 O O   . VAL A 1 323 ? 52.195 -18.197 1.259   1.00 20.67 ?  313 VAL A O   1 
ATOM   2325 C CB  . VAL A 1 323 ? 53.088 -20.709 2.796   1.00 22.86 ?  313 VAL A CB  1 
ATOM   2326 C CG1 . VAL A 1 323 ? 54.504 -20.216 3.114   1.00 24.53 ?  313 VAL A CG1 1 
ATOM   2327 C CG2 . VAL A 1 323 ? 52.826 -22.006 3.540   1.00 29.04 ?  313 VAL A CG2 1 
ATOM   2328 N N   . VAL A 1 324 ? 52.780 -17.351 3.283   1.00 21.11 ?  314 VAL A N   1 
ATOM   2329 C CA  . VAL A 1 324 ? 52.915 -15.966 2.843   1.00 22.08 ?  314 VAL A CA  1 
ATOM   2330 C C   . VAL A 1 324 ? 54.247 -15.442 3.355   1.00 22.30 ?  314 VAL A C   1 
ATOM   2331 O O   . VAL A 1 324 ? 54.453 -15.367 4.572   1.00 24.10 ?  314 VAL A O   1 
ATOM   2332 C CB  . VAL A 1 324 ? 51.767 -15.078 3.356   1.00 23.52 ?  314 VAL A CB  1 
ATOM   2333 C CG1 . VAL A 1 324 ? 51.983 -13.639 2.914   1.00 24.62 ?  314 VAL A CG1 1 
ATOM   2334 C CG2 . VAL A 1 324 ? 50.401 -15.570 2.814   1.00 21.49 ?  314 VAL A CG2 1 
ATOM   2335 N N   . ASN A 1 325 ? 55.159 -15.083 2.442   1.00 24.75 ?  315 ASN A N   1 
ATOM   2336 C CA  . ASN A 1 325 ? 56.467 -14.542 2.833   1.00 25.82 ?  315 ASN A CA  1 
ATOM   2337 C C   . ASN A 1 325 ? 56.773 -13.274 2.056   1.00 25.42 ?  315 ASN A C   1 
ATOM   2338 O O   . ASN A 1 325 ? 56.746 -13.289 0.824   1.00 28.57 ?  315 ASN A O   1 
ATOM   2339 C CB  . ASN A 1 325 ? 57.613 -15.541 2.589   1.00 28.73 ?  315 ASN A CB  1 
ATOM   2340 C CG  . ASN A 1 325 ? 57.677 -16.624 3.641   1.00 30.46 ?  315 ASN A CG  1 
ATOM   2341 O OD1 . ASN A 1 325 ? 58.139 -16.379 4.758   1.00 31.49 ?  315 ASN A OD1 1 
ATOM   2342 N ND2 . ASN A 1 325 ? 57.190 -17.830 3.303   1.00 27.59 ?  315 ASN A ND2 1 
ATOM   2343 N N   . ASP A 1 326 ? 57.097 -12.200 2.780   1.00 27.72 ?  316 ASP A N   1 
ATOM   2344 C CA  . ASP A 1 326 ? 57.579 -10.930 2.198   1.00 32.32 ?  316 ASP A CA  1 
ATOM   2345 C C   . ASP A 1 326 ? 56.617 -10.376 1.139   1.00 26.43 ?  316 ASP A C   1 
ATOM   2346 O O   . ASP A 1 326 ? 57.013 -9.965  0.045   1.00 31.74 ?  316 ASP A O   1 
ATOM   2347 C CB  . ASP A 1 326 ? 58.987 -11.109 1.608   1.00 29.85 ?  316 ASP A CB  1 
ATOM   2348 C CG  . ASP A 1 326 ? 59.989 -11.577 2.652   1.00 39.63 ?  316 ASP A CG  1 
ATOM   2349 O OD1 . ASP A 1 326 ? 60.544 -10.715 3.355   1.00 43.51 ?  316 ASP A OD1 1 
ATOM   2350 O OD2 . ASP A 1 326 ? 60.307 -12.790 2.708   1.00 40.96 ?  316 ASP A OD2 1 
ATOM   2351 N N   . ALA A 1 327 ? 55.341 -10.358 1.470   1.00 26.66 ?  317 ALA A N   1 
ATOM   2352 C CA  . ALA A 1 327 ? 54.299 -10.080 0.504   1.00 24.88 ?  317 ALA A CA  1 
ATOM   2353 C C   . ALA A 1 327 ? 53.412 -8.982  1.048   1.00 24.62 ?  317 ALA A C   1 
ATOM   2354 O O   . ALA A 1 327 ? 53.400 -8.700  2.255   1.00 25.90 ?  317 ALA A O   1 
ATOM   2355 C CB  . ALA A 1 327 ? 53.471 -11.337 0.212   1.00 24.59 ?  317 ALA A CB  1 
ATOM   2356 N N   . SER A 1 328 ? 52.617 -8.392  0.159   1.00 25.26 ?  318 SER A N   1 
ATOM   2357 C CA  . SER A 1 328 ? 51.604 -7.441  0.591   1.00 30.43 ?  318 SER A CA  1 
ATOM   2358 C C   . SER A 1 328 ? 50.235 -7.838  0.043   1.00 30.77 ?  318 SER A C   1 
ATOM   2359 O O   . SER A 1 328 ? 50.094 -8.217  -1.129  1.00 27.48 ?  318 SER A O   1 
ATOM   2360 C CB  . SER A 1 328 ? 51.974 -5.991  0.169   1.00 27.84 ?  318 SER A CB  1 
ATOM   2361 O OG  . SER A 1 328 ? 51.724 -5.797  -1.205  1.00 44.43 ?  318 SER A OG  1 
ATOM   2362 N N   . VAL A 1 329 ? 49.223 -7.736  0.897   1.00 22.62 ?  319 VAL A N   1 
ATOM   2363 C CA  . VAL A 1 329 ? 47.855 -8.141  0.561   1.00 21.93 ?  319 VAL A CA  1 
ATOM   2364 C C   . VAL A 1 329 ? 46.928 -6.970  0.851   1.00 24.61 ?  319 VAL A C   1 
ATOM   2365 O O   . VAL A 1 329 ? 46.830 -6.524  2.005   1.00 27.63 ?  319 VAL A O   1 
ATOM   2366 C CB  . VAL A 1 329 ? 47.437 -9.383  1.368   1.00 23.39 ?  319 VAL A CB  1 
ATOM   2367 C CG1 . VAL A 1 329 ? 46.044 -9.831  1.002   1.00 26.52 ?  319 VAL A CG1 1 
ATOM   2368 C CG2 . VAL A 1 329 ? 48.461 -10.511 1.171   1.00 21.78 ?  319 VAL A CG2 1 
ATOM   2369 N N   . GLY A 1 330 ? 46.240 -6.469  -0.187  1.00 23.09 ?  320 GLY A N   1 
ATOM   2370 C CA  . GLY A 1 330 ? 45.374 -5.309  -0.032  1.00 27.13 ?  320 GLY A CA  1 
ATOM   2371 C C   . GLY A 1 330 ? 44.032 -5.595  0.638   1.00 28.67 ?  320 GLY A C   1 
ATOM   2372 O O   . GLY A 1 330 ? 43.685 -6.725  0.992   1.00 27.72 ?  320 GLY A O   1 
ATOM   2373 N N   . ALA A 1 331 ? 43.249 -4.528  0.798   1.00 23.03 ?  321 ALA A N   1 
ATOM   2374 C CA  . ALA A 1 331 ? 42.013 -4.607  1.579   1.00 25.05 ?  321 ALA A CA  1 
ATOM   2375 C C   . ALA A 1 331 ? 40.990 -5.555  0.941   1.00 27.43 ?  321 ALA A C   1 
ATOM   2376 O O   . ALA A 1 331 ? 40.800 -5.569  -0.276  1.00 26.80 ?  321 ALA A O   1 
ATOM   2377 C CB  . ALA A 1 331 ? 41.418 -3.203  1.737   1.00 28.80 ?  321 ALA A CB  1 
ATOM   2378 N N   . ASN A 1 332 ? 40.342 -6.364  1.779   1.00 21.81 ?  322 ASN A N   1 
ATOM   2379 C CA  . ASN A 1 332 ? 39.260 -7.280  1.383   1.00 27.54 ?  322 ASN A CA  1 
ATOM   2380 C C   . ASN A 1 332 ? 39.696 -8.319  0.350   1.00 30.09 ?  322 ASN A C   1 
ATOM   2381 O O   . ASN A 1 332 ? 38.878 -8.837  -0.409  1.00 29.57 ?  322 ASN A O   1 
ATOM   2382 C CB  . ASN A 1 332 ? 38.037 -6.523  0.863   1.00 28.65 ?  322 ASN A CB  1 
ATOM   2383 C CG  . ASN A 1 332 ? 37.548 -5.511  1.854   1.00 37.28 ?  322 ASN A CG  1 
ATOM   2384 O OD1 . ASN A 1 332 ? 37.218 -5.866  2.987   1.00 31.64 ?  322 ASN A OD1 1 
ATOM   2385 N ND2 . ASN A 1 332 ? 37.576 -4.238  1.472   1.00 31.72 ?  322 ASN A ND2 1 
ATOM   2386 N N   . THR A 1 333 ? 40.970 -8.644  0.321   1.00 23.43 ?  323 THR A N   1 
ATOM   2387 C CA  . THR A 1 333 ? 41.478 -9.640  -0.609  1.00 25.82 ?  323 THR A CA  1 
ATOM   2388 C C   . THR A 1 333 ? 41.451 -11.014 0.042   1.00 27.34 ?  323 THR A C   1 
ATOM   2389 O O   . THR A 1 333 ? 41.619 -11.141 1.258   1.00 25.52 ?  323 THR A O   1 
ATOM   2390 C CB  . THR A 1 333 ? 42.882 -9.226  -1.038  1.00 27.91 ?  323 THR A CB  1 
ATOM   2391 O OG1 . THR A 1 333 ? 42.747 -8.157  -1.975  1.00 28.40 ?  323 THR A OG1 1 
ATOM   2392 C CG2 . THR A 1 333 ? 43.662 -10.363 -1.690  1.00 25.36 ?  323 THR A CG2 1 
ATOM   2393 N N   . LYS A 1 334 ? 41.206 -12.043 -0.771  1.00 24.14 ?  324 LYS A N   1 
ATOM   2394 C CA  . LYS A 1 334 ? 41.032 -13.406 -0.285  1.00 23.46 ?  324 LYS A CA  1 
ATOM   2395 C C   . LYS A 1 334 ? 42.103 -14.319 -0.867  1.00 26.63 ?  324 LYS A C   1 
ATOM   2396 O O   . LYS A 1 334 ? 42.340 -14.320 -2.087  1.00 24.27 ?  324 LYS A O   1 
ATOM   2397 C CB  . LYS A 1 334 ? 39.634 -13.923 -0.631  1.00 28.87 ?  324 LYS A CB  1 
ATOM   2398 C CG  . LYS A 1 334 ? 39.462 -15.425 -0.405  1.00 38.90 ?  324 LYS A CG  1 
ATOM   2399 C CD  . LYS A 1 334 ? 38.532 -15.794 0.741   1.00 51.05 ?  324 LYS A CD  1 
ATOM   2400 C CE  . LYS A 1 334 ? 38.437 -17.319 0.897   1.00 51.59 ?  324 LYS A CE  1 
ATOM   2401 N NZ  . LYS A 1 334 ? 37.018 -17.823 0.884   1.00 50.29 ?  324 LYS A NZ  1 
ATOM   2402 N N   . VAL A 1 335 ? 42.765 -15.083 0.006   1.00 21.66 ?  325 VAL A N   1 
ATOM   2403 C CA  . VAL A 1 335 ? 43.920 -15.895 -0.368  1.00 21.27 ?  325 VAL A CA  1 
ATOM   2404 C C   . VAL A 1 335 ? 43.729 -17.292 0.204   1.00 27.92 ?  325 VAL A C   1 
ATOM   2405 O O   . VAL A 1 335 ? 43.546 -17.446 1.418   1.00 24.92 ?  325 VAL A O   1 
ATOM   2406 C CB  . VAL A 1 335 ? 45.235 -15.301 0.156   1.00 18.35 ?  325 VAL A CB  1 
ATOM   2407 C CG1 . VAL A 1 335 ? 46.416 -16.244 -0.154  1.00 19.05 ?  325 VAL A CG1 1 
ATOM   2408 C CG2 . VAL A 1 335 ? 45.504 -13.871 -0.449  1.00 24.44 ?  325 VAL A CG2 1 
ATOM   2409 N N   . GLY A 1 336 ? 43.762 -18.303 -0.657  1.00 22.74 ?  326 GLY A N   1 
ATOM   2410 C CA  . GLY A 1 336 ? 43.726 -19.676 -0.188  1.00 24.72 ?  326 GLY A CA  1 
ATOM   2411 C C   . GLY A 1 336 ? 42.366 -20.306 -0.363  1.00 25.54 ?  326 GLY A C   1 
ATOM   2412 O O   . GLY A 1 336 ? 41.474 -19.724 -0.981  1.00 26.19 ?  326 GLY A O   1 
ATOM   2413 N N   . PRO A 1 337 ? 42.172 -21.531 0.170   1.00 23.95 ?  327 PRO A N   1 
ATOM   2414 C CA  . PRO A 1 337 ? 43.124 -22.349 0.944   1.00 24.09 ?  327 PRO A CA  1 
ATOM   2415 C C   . PRO A 1 337 ? 44.237 -22.930 0.092   1.00 23.08 ?  327 PRO A C   1 
ATOM   2416 O O   . PRO A 1 337 ? 44.114 -23.060 -1.125  1.00 23.09 ?  327 PRO A O   1 
ATOM   2417 C CB  . PRO A 1 337 ? 42.224 -23.456 1.540   1.00 28.09 ?  327 PRO A CB  1 
ATOM   2418 C CG  . PRO A 1 337 ? 41.176 -23.674 0.454   1.00 24.40 ?  327 PRO A CG  1 
ATOM   2419 C CD  . PRO A 1 337 ? 40.888 -22.241 -0.041  1.00 27.29 ?  327 PRO A CD  1 
ATOM   2420 N N   . PHE A 1 338 ? 45.366 -23.243 0.715   1.00 25.41 ?  328 PHE A N   1 
ATOM   2421 C CA  . PHE A 1 338 ? 46.493 -23.868 0.029   1.00 24.05 ?  328 PHE A CA  1 
ATOM   2422 C C   . PHE A 1 338 ? 47.013 -23.005 -1.130  1.00 27.28 ?  328 PHE A C   1 
ATOM   2423 O O   . PHE A 1 338 ? 47.172 -23.488 -2.247  1.00 23.61 ?  328 PHE A O   1 
ATOM   2424 C CB  . PHE A 1 338 ? 46.125 -25.276 -0.469  1.00 24.82 ?  328 PHE A CB  1 
ATOM   2425 C CG  . PHE A 1 338 ? 45.412 -26.153 0.556   1.00 29.48 ?  328 PHE A CG  1 
ATOM   2426 C CD1 . PHE A 1 338 ? 46.027 -26.484 1.743   1.00 30.68 ?  328 PHE A CD1 1 
ATOM   2427 C CD2 . PHE A 1 338 ? 44.154 -26.725 0.267   1.00 34.02 ?  328 PHE A CD2 1 
ATOM   2428 C CE1 . PHE A 1 338 ? 45.397 -27.307 2.691   1.00 29.03 ?  328 PHE A CE1 1 
ATOM   2429 C CE2 . PHE A 1 338 ? 43.513 -27.589 1.193   1.00 26.76 ?  328 PHE A CE2 1 
ATOM   2430 C CZ  . PHE A 1 338 ? 44.148 -27.879 2.423   1.00 27.45 ?  328 PHE A CZ  1 
ATOM   2431 N N   . ALA A 1 339 ? 47.289 -21.724 -0.858  1.00 21.18 ?  329 ALA A N   1 
ATOM   2432 C CA  . ALA A 1 339 ? 47.995 -20.856 -1.799  1.00 18.78 ?  329 ALA A CA  1 
ATOM   2433 C C   . ALA A 1 339 ? 49.368 -20.473 -1.257  1.00 21.64 ?  329 ALA A C   1 
ATOM   2434 O O   . ALA A 1 339 ? 49.637 -20.539 -0.050  1.00 20.69 ?  329 ALA A O   1 
ATOM   2435 C CB  . ALA A 1 339 ? 47.171 -19.598 -2.103  1.00 19.86 ?  329 ALA A CB  1 
ATOM   2436 N N   . GLN A 1 340 ? 50.264 -20.033 -2.138  1.00 21.22 ?  330 GLN A N   1 
ATOM   2437 C CA  . GLN A 1 340 ? 51.552 -19.534 -1.659  1.00 19.03 ?  330 GLN A CA  1 
ATOM   2438 C C   . GLN A 1 340 ? 51.860 -18.168 -2.253  1.00 22.28 ?  330 GLN A C   1 
ATOM   2439 O O   . GLN A 1 340 ? 51.876 -17.997 -3.482  1.00 20.18 ?  330 GLN A O   1 
ATOM   2440 C CB  . GLN A 1 340 ? 52.705 -20.498 -1.964  1.00 17.60 ?  330 GLN A CB  1 
ATOM   2441 C CG  . GLN A 1 340 ? 53.970 -20.025 -1.226  1.00 24.09 ?  330 GLN A CG  1 
ATOM   2442 C CD  . GLN A 1 340 ? 55.234 -20.803 -1.552  1.00 27.15 ?  330 GLN A CD  1 
ATOM   2443 O OE1 . GLN A 1 340 ? 55.278 -21.623 -2.483  1.00 29.36 ?  330 GLN A OE1 1 
ATOM   2444 N NE2 . GLN A 1 340 ? 56.259 -20.583 -0.748  1.00 26.50 ?  330 GLN A NE2 1 
ATOM   2445 N N   . LEU A 1 341 ? 52.101 -17.196 -1.391  1.00 20.99 ?  331 LEU A N   1 
ATOM   2446 C CA  . LEU A 1 341 ? 52.607 -15.899 -1.817  1.00 26.55 ?  331 LEU A CA  1 
ATOM   2447 C C   . LEU A 1 341 ? 54.094 -15.836 -1.476  1.00 27.28 ?  331 LEU A C   1 
ATOM   2448 O O   . LEU A 1 341 ? 54.475 -15.828 -0.295  1.00 22.53 ?  331 LEU A O   1 
ATOM   2449 C CB  . LEU A 1 341 ? 51.858 -14.762 -1.129  1.00 26.11 ?  331 LEU A CB  1 
ATOM   2450 C CG  . LEU A 1 341 ? 50.334 -14.802 -1.247  1.00 27.55 ?  331 LEU A CG  1 
ATOM   2451 C CD1 . LEU A 1 341 ? 49.685 -13.605 -0.508  1.00 26.78 ?  331 LEU A CD1 1 
ATOM   2452 C CD2 . LEU A 1 341 ? 49.904 -14.850 -2.721  1.00 25.94 ?  331 LEU A CD2 1 
ATOM   2453 N N   . ARG A 1 342 ? 54.923 -15.746 -2.491  1.00 22.62 ?  332 ARG A N   1 
ATOM   2454 C CA  . ARG A 1 342 ? 56.369 -15.713 -2.319  1.00 25.35 ?  332 ARG A CA  1 
ATOM   2455 C C   . ARG A 1 342 ? 56.872 -14.281 -2.309  1.00 31.92 ?  332 ARG A C   1 
ATOM   2456 O O   . ARG A 1 342 ? 56.148 -13.353 -2.676  1.00 29.43 ?  332 ARG A O   1 
ATOM   2457 C CB  . ARG A 1 342 ? 57.029 -16.520 -3.435  1.00 29.99 ?  332 ARG A CB  1 
ATOM   2458 C CG  . ARG A 1 342 ? 56.966 -18.036 -3.157  1.00 30.02 ?  332 ARG A CG  1 
ATOM   2459 C CD  . ARG A 1 342 ? 57.373 -18.856 -4.370  1.00 32.30 ?  332 ARG A CD  1 
ATOM   2460 N NE  . ARG A 1 342 ? 58.816 -18.799 -4.597  1.00 39.61 ?  332 ARG A NE  1 
ATOM   2461 C CZ  . ARG A 1 342 ? 59.390 -18.892 -5.793  1.00 39.61 ?  332 ARG A CZ  1 
ATOM   2462 N NH1 . ARG A 1 342 ? 58.680 -19.140 -6.885  1.00 36.86 ?  332 ARG A NH1 1 
ATOM   2463 N NH2 . ARG A 1 342 ? 60.707 -18.724 -5.899  1.00 43.50 ?  332 ARG A NH2 1 
ATOM   2464 N N   . PRO A 1 343 ? 58.122 -14.056 -1.891  1.00 30.36 ?  333 PRO A N   1 
ATOM   2465 C CA  . PRO A 1 343 ? 58.635 -12.678 -1.793  1.00 31.98 ?  333 PRO A CA  1 
ATOM   2466 C C   . PRO A 1 343 ? 58.309 -11.819 -3.015  1.00 29.86 ?  333 PRO A C   1 
ATOM   2467 O O   . PRO A 1 343 ? 58.456 -12.248 -4.161  1.00 31.81 ?  333 PRO A O   1 
ATOM   2468 C CB  . PRO A 1 343 ? 60.147 -12.890 -1.629  1.00 30.86 ?  333 PRO A CB  1 
ATOM   2469 C CG  . PRO A 1 343 ? 60.188 -14.153 -0.744  1.00 29.24 ?  333 PRO A CG  1 
ATOM   2470 C CD  . PRO A 1 343 ? 59.127 -15.034 -1.409  1.00 26.87 ?  333 PRO A CD  1 
ATOM   2471 N N   . GLY A 1 344 ? 57.840 -10.599 -2.759  1.00 26.00 ?  334 GLY A N   1 
ATOM   2472 C CA  . GLY A 1 344 ? 57.503 -9.697  -3.840  1.00 29.96 ?  334 GLY A CA  1 
ATOM   2473 C C   . GLY A 1 344 ? 56.106 -9.842  -4.392  1.00 31.41 ?  334 GLY A C   1 
ATOM   2474 O O   . GLY A 1 344 ? 55.729 -9.083  -5.307  1.00 33.37 ?  334 GLY A O   1 
ATOM   2475 N N   . ALA A 1 345 ? 55.311 -10.767 -3.875  1.00 24.79 ?  335 ALA A N   1 
ATOM   2476 C CA  . ALA A 1 345 ? 53.918 -10.821 -4.293  1.00 29.35 ?  335 ALA A CA  1 
ATOM   2477 C C   . ALA A 1 345 ? 53.217 -9.583  -3.756  1.00 28.83 ?  335 ALA A C   1 
ATOM   2478 O O   . ALA A 1 345 ? 53.309 -9.277  -2.561  1.00 26.57 ?  335 ALA A O   1 
ATOM   2479 C CB  . ALA A 1 345 ? 53.250 -12.098 -3.766  1.00 26.58 ?  335 ALA A CB  1 
ATOM   2480 N N   . GLN A 1 346 ? 52.530 -8.858  -4.623  1.00 21.54 ?  336 GLN A N   1 
ATOM   2481 C CA  . GLN A 1 346 ? 51.802 -7.665  -4.204  1.00 24.92 ?  336 GLN A CA  1 
ATOM   2482 C C   . GLN A 1 346 ? 50.379 -7.746  -4.753  1.00 30.81 ?  336 GLN A C   1 
ATOM   2483 O O   . GLN A 1 346 ? 50.174 -7.691  -5.971  1.00 26.33 ?  336 GLN A O   1 
ATOM   2484 C CB  . GLN A 1 346 ? 52.558 -6.422  -4.673  1.00 30.50 ?  336 GLN A CB  1 
ATOM   2485 C CG  . GLN A 1 346 ? 51.801 -5.127  -4.637  1.00 36.85 ?  336 GLN A CG  1 
ATOM   2486 C CD  . GLN A 1 346 ? 52.625 -4.008  -5.269  1.00 57.73 ?  336 GLN A CD  1 
ATOM   2487 O OE1 . GLN A 1 346 ? 53.850 -3.939  -5.081  1.00 54.77 ?  336 GLN A OE1 1 
ATOM   2488 N NE2 . GLN A 1 346 ? 51.962 -3.133  -6.026  1.00 57.12 ?  336 GLN A NE2 1 
ATOM   2489 N N   . LEU A 1 347 ? 49.399 -7.952  -3.866  1.00 21.02 ?  337 LEU A N   1 
ATOM   2490 C CA  . LEU A 1 347 ? 47.999 -8.101  -4.259  1.00 23.78 ?  337 LEU A CA  1 
ATOM   2491 C C   . LEU A 1 347 ? 47.257 -6.829  -3.908  1.00 25.69 ?  337 LEU A C   1 
ATOM   2492 O O   . LEU A 1 347 ? 47.329 -6.369  -2.769  1.00 23.97 ?  337 LEU A O   1 
ATOM   2493 C CB  . LEU A 1 347 ? 47.305 -9.279  -3.548  1.00 22.81 ?  337 LEU A CB  1 
ATOM   2494 C CG  . LEU A 1 347 ? 48.067 -10.598 -3.401  1.00 26.70 ?  337 LEU A CG  1 
ATOM   2495 C CD1 . LEU A 1 347 ? 47.114 -11.722 -2.945  1.00 27.55 ?  337 LEU A CD1 1 
ATOM   2496 C CD2 . LEU A 1 347 ? 48.784 -10.977 -4.663  1.00 30.93 ?  337 LEU A CD2 1 
ATOM   2497 N N   . GLY A 1 348 ? 46.503 -6.303  -4.862  1.00 22.02 ?  338 GLY A N   1 
ATOM   2498 C CA  . GLY A 1 348 ? 45.681 -5.130  -4.619  1.00 31.48 ?  338 GLY A CA  1 
ATOM   2499 C C   . GLY A 1 348 ? 44.458 -5.438  -3.777  1.00 36.56 ?  338 GLY A C   1 
ATOM   2500 O O   . GLY A 1 348 ? 44.370 -6.464  -3.094  1.00 31.88 ?  338 GLY A O   1 
ATOM   2501 N N   . ALA A 1 349 ? 43.507 -4.508  -3.811  1.00 25.17 ?  339 ALA A N   1 
ATOM   2502 C CA  . ALA A 1 349 ? 42.281 -4.674  -3.047  1.00 26.73 ?  339 ALA A CA  1 
ATOM   2503 C C   . ALA A 1 349 ? 41.283 -5.534  -3.803  1.00 24.88 ?  339 ALA A C   1 
ATOM   2504 O O   . ALA A 1 349 ? 41.238 -5.529  -5.035  1.00 24.15 ?  339 ALA A O   1 
ATOM   2505 C CB  . ALA A 1 349 ? 41.651 -3.315  -2.732  1.00 30.61 ?  339 ALA A CB  1 
ATOM   2506 N N   . ASP A 1 350 ? 40.456 -6.256  -3.045  1.00 21.36 ?  340 ASP A N   1 
ATOM   2507 C CA  . ASP A 1 350 ? 39.397 -7.093  -3.610  1.00 25.06 ?  340 ASP A CA  1 
ATOM   2508 C C   . ASP A 1 350 ? 39.938 -8.125  -4.611  1.00 26.49 ?  340 ASP A C   1 
ATOM   2509 O O   . ASP A 1 350 ? 39.239 -8.511  -5.543  1.00 27.36 ?  340 ASP A O   1 
ATOM   2510 C CB  . ASP A 1 350 ? 38.310 -6.230  -4.270  1.00 26.93 ?  340 ASP A CB  1 
ATOM   2511 C CG  . ASP A 1 350 ? 37.624 -5.277  -3.277  1.00 36.90 ?  340 ASP A CG  1 
ATOM   2512 O OD1 . ASP A 1 350 ? 36.962 -5.765  -2.325  1.00 35.57 ?  340 ASP A OD1 1 
ATOM   2513 O OD2 . ASP A 1 350 ? 37.761 -4.048  -3.437  1.00 32.87 ?  340 ASP A OD2 1 
ATOM   2514 N N   . VAL A 1 351 ? 41.182 -8.566  -4.440  1.00 25.29 ?  341 VAL A N   1 
ATOM   2515 C CA  . VAL A 1 351 ? 41.777 -9.599  -5.288  1.00 23.54 ?  341 VAL A CA  1 
ATOM   2516 C C   . VAL A 1 351 ? 41.404 -10.987 -4.771  1.00 28.41 ?  341 VAL A C   1 
ATOM   2517 O O   . VAL A 1 351 ? 41.133 -11.199 -3.583  1.00 28.32 ?  341 VAL A O   1 
ATOM   2518 C CB  . VAL A 1 351 ? 43.307 -9.388  -5.357  1.00 26.37 ?  341 VAL A CB  1 
ATOM   2519 C CG1 . VAL A 1 351 ? 44.082 -10.670 -5.863  1.00 24.20 ?  341 VAL A CG1 1 
ATOM   2520 C CG2 . VAL A 1 351 ? 43.599 -8.199  -6.250  1.00 28.37 ?  341 VAL A CG2 1 
ATOM   2521 N N   . LYS A 1 352 ? 41.334 -11.955 -5.668  1.00 25.69 ?  342 LYS A N   1 
ATOM   2522 C CA  . LYS A 1 352 ? 41.145 -13.335 -5.248  1.00 23.07 ?  342 LYS A CA  1 
ATOM   2523 C C   . LYS A 1 352 ? 42.291 -14.208 -5.746  1.00 26.27 ?  342 LYS A C   1 
ATOM   2524 O O   . LYS A 1 352 ? 42.591 -14.226 -6.945  1.00 27.27 ?  342 LYS A O   1 
ATOM   2525 C CB  . LYS A 1 352 ? 39.806 -13.882 -5.737  1.00 28.05 ?  342 LYS A CB  1 
ATOM   2526 C CG  . LYS A 1 352 ? 39.806 -15.388 -5.726  1.00 35.95 ?  342 LYS A CG  1 
ATOM   2527 C CD  . LYS A 1 352 ? 39.441 -15.952 -4.387  1.00 42.84 ?  342 LYS A CD  1 
ATOM   2528 C CE  . LYS A 1 352 ? 38.663 -17.266 -4.531  1.00 47.62 ?  342 LYS A CE  1 
ATOM   2529 N NZ  . LYS A 1 352 ? 38.063 -17.644 -3.222  1.00 44.52 ?  342 LYS A NZ  1 
ATOM   2530 N N   . VAL A 1 353 ? 42.938 -14.914 -4.818  1.00 22.39 ?  343 VAL A N   1 
ATOM   2531 C CA  . VAL A 1 353 ? 43.990 -15.886 -5.117  1.00 21.85 ?  343 VAL A CA  1 
ATOM   2532 C C   . VAL A 1 353 ? 43.539 -17.213 -4.504  1.00 29.76 ?  343 VAL A C   1 
ATOM   2533 O O   . VAL A 1 353 ? 43.485 -17.352 -3.272  1.00 24.78 ?  343 VAL A O   1 
ATOM   2534 C CB  . VAL A 1 353 ? 45.361 -15.427 -4.587  1.00 25.25 ?  343 VAL A CB  1 
ATOM   2535 C CG1 . VAL A 1 353 ? 46.439 -16.523 -4.736  1.00 21.39 ?  343 VAL A CG1 1 
ATOM   2536 C CG2 . VAL A 1 353 ? 45.816 -14.174 -5.335  1.00 27.15 ?  343 VAL A CG2 1 
ATOM   2537 N N   . GLY A 1 354 ? 43.184 -18.169 -5.369  1.00 26.75 ?  344 GLY A N   1 
ATOM   2538 C CA  . GLY A 1 354 ? 42.456 -19.363 -4.976  1.00 31.43 ?  344 GLY A CA  1 
ATOM   2539 C C   . GLY A 1 354 ? 43.373 -20.508 -4.610  1.00 30.78 ?  344 GLY A C   1 
ATOM   2540 O O   . GLY A 1 354 ? 44.584 -20.341 -4.438  1.00 27.77 ?  344 GLY A O   1 
ATOM   2541 N N   . ASN A 1 355 ? 42.779 -21.702 -4.474  1.00 26.27 ?  345 ASN A N   1 
ATOM   2542 C CA  . ASN A 1 355 ? 43.572 -22.840 -4.028  1.00 27.07 ?  345 ASN A CA  1 
ATOM   2543 C C   . ASN A 1 355 ? 44.595 -23.248 -5.073  1.00 22.66 ?  345 ASN A C   1 
ATOM   2544 O O   . ASN A 1 355 ? 44.360 -23.147 -6.286  1.00 23.65 ?  345 ASN A O   1 
ATOM   2545 C CB  . ASN A 1 355 ? 42.702 -24.063 -3.652  1.00 27.75 ?  345 ASN A CB  1 
ATOM   2546 C CG  . ASN A 1 355 ? 41.746 -24.513 -4.734  1.00 30.85 ?  345 ASN A CG  1 
ATOM   2547 O OD1 . ASN A 1 355 ? 41.877 -24.208 -5.944  1.00 29.24 ?  345 ASN A OD1 1 
ATOM   2548 N ND2 . ASN A 1 355 ? 40.774 -25.300 -4.304  1.00 24.60 ?  345 ASN A ND2 1 
ATOM   2549 N N   . PHE A 1 356 ? 45.761 -23.680 -4.580  1.00 23.93 ?  346 PHE A N   1 
ATOM   2550 C CA  . PHE A 1 356 ? 46.851 -24.194 -5.404  1.00 25.80 ?  346 PHE A CA  1 
ATOM   2551 C C   . PHE A 1 356 ? 47.349 -23.139 -6.390  1.00 24.15 ?  346 PHE A C   1 
ATOM   2552 O O   . PHE A 1 356 ? 47.706 -23.450 -7.525  1.00 23.32 ?  346 PHE A O   1 
ATOM   2553 C CB  . PHE A 1 356 ? 46.449 -25.495 -6.124  1.00 25.01 ?  346 PHE A CB  1 
ATOM   2554 C CG  . PHE A 1 356 ? 45.511 -26.344 -5.317  1.00 23.64 ?  346 PHE A CG  1 
ATOM   2555 C CD1 . PHE A 1 356 ? 45.854 -26.724 -4.017  1.00 20.41 ?  346 PHE A CD1 1 
ATOM   2556 C CD2 . PHE A 1 356 ? 44.265 -26.711 -5.825  1.00 26.10 ?  346 PHE A CD2 1 
ATOM   2557 C CE1 . PHE A 1 356 ? 44.949 -27.458 -3.231  1.00 23.40 ?  346 PHE A CE1 1 
ATOM   2558 C CE2 . PHE A 1 356 ? 43.372 -27.452 -5.073  1.00 21.53 ?  346 PHE A CE2 1 
ATOM   2559 C CZ  . PHE A 1 356 ? 43.707 -27.835 -3.760  1.00 22.98 ?  346 PHE A CZ  1 
ATOM   2560 N N   . VAL A 1 357 ? 47.433 -21.888 -5.940  1.00 19.30 ?  347 VAL A N   1 
ATOM   2561 C CA  . VAL A 1 357 ? 48.006 -20.806 -6.738  1.00 18.62 ?  347 VAL A CA  1 
ATOM   2562 C C   . VAL A 1 357 ? 49.277 -20.315 -6.076  1.00 22.27 ?  347 VAL A C   1 
ATOM   2563 O O   . VAL A 1 357 ? 49.364 -20.210 -4.840  1.00 22.86 ?  347 VAL A O   1 
ATOM   2564 C CB  . VAL A 1 357 ? 47.007 -19.647 -6.944  1.00 23.03 ?  347 VAL A CB  1 
ATOM   2565 C CG1 . VAL A 1 357 ? 47.675 -18.460 -7.651  1.00 24.28 ?  347 VAL A CG1 1 
ATOM   2566 C CG2 . VAL A 1 357 ? 45.842 -20.132 -7.780  1.00 24.63 ?  347 VAL A CG2 1 
ATOM   2567 N N   . GLU A 1 358 ? 50.281 -20.040 -6.902  1.00 19.49 ?  348 GLU A N   1 
ATOM   2568 C CA  . GLU A 1 358 ? 51.557 -19.497 -6.439  1.00 19.15 ?  348 GLU A CA  1 
ATOM   2569 C C   . GLU A 1 358 ? 51.812 -18.130 -7.067  1.00 19.61 ?  348 GLU A C   1 
ATOM   2570 O O   . GLU A 1 358 ? 51.706 -17.973 -8.280  1.00 20.92 ?  348 GLU A O   1 
ATOM   2571 C CB  . GLU A 1 358 ? 52.691 -20.482 -6.773  1.00 21.36 ?  348 GLU A CB  1 
ATOM   2572 C CG  . GLU A 1 358 ? 54.112 -19.932 -6.482  1.00 25.82 ?  348 GLU A CG  1 
ATOM   2573 C CD  . GLU A 1 358 ? 55.219 -20.916 -6.911  1.00 33.05 ?  348 GLU A CD  1 
ATOM   2574 O OE1 . GLU A 1 358 ? 54.943 -21.887 -7.665  1.00 31.47 ?  348 GLU A OE1 1 
ATOM   2575 O OE2 . GLU A 1 358 ? 56.392 -20.651 -6.602  1.00 31.32 -1 348 GLU A OE2 1 
ATOM   2576 N N   . ILE A 1 359 ? 52.113 -17.130 -6.246  1.00 22.63 ?  349 ILE A N   1 
ATOM   2577 C CA  . ILE A 1 359 ? 52.400 -15.771 -6.720  1.00 22.69 ?  349 ILE A CA  1 
ATOM   2578 C C   . ILE A 1 359 ? 53.815 -15.397 -6.276  1.00 24.37 ?  349 ILE A C   1 
ATOM   2579 O O   . ILE A 1 359 ? 54.137 -15.489 -5.085  1.00 21.87 ?  349 ILE A O   1 
ATOM   2580 C CB  . ILE A 1 359 ? 51.394 -14.745 -6.162  1.00 25.95 ?  349 ILE A CB  1 
ATOM   2581 C CG1 . ILE A 1 359 ? 49.931 -15.174 -6.367  1.00 25.48 ?  349 ILE A CG1 1 
ATOM   2582 C CG2 . ILE A 1 359 ? 51.618 -13.368 -6.820  1.00 22.75 ?  349 ILE A CG2 1 
ATOM   2583 C CD1 . ILE A 1 359 ? 49.498 -15.287 -7.842  1.00 24.06 ?  349 ILE A CD1 1 
ATOM   2584 N N   . LYS A 1 360 ? 54.653 -14.940 -7.214  1.00 25.58 ?  350 LYS A N   1 
ATOM   2585 C CA  . LYS A 1 360 ? 56.022 -14.549 -6.867  1.00 23.19 ?  350 LYS A CA  1 
ATOM   2586 C C   . LYS A 1 360 ? 56.462 -13.322 -7.667  1.00 23.09 ?  350 LYS A C   1 
ATOM   2587 O O   . LYS A 1 360 ? 56.402 -13.340 -8.899  1.00 26.70 ?  350 LYS A O   1 
ATOM   2588 C CB  . LYS A 1 360 ? 56.992 -15.704 -7.136  1.00 28.38 ?  350 LYS A CB  1 
ATOM   2589 C CG  . LYS A 1 360 ? 58.466 -15.367 -6.804  1.00 35.30 ?  350 LYS A CG  1 
ATOM   2590 C CD  . LYS A 1 360 ? 59.447 -15.917 -7.840  1.00 38.38 ?  350 LYS A CD  1 
ATOM   2591 C CE  . LYS A 1 360 ? 59.622 -14.969 -9.024  1.00 33.39 ?  350 LYS A CE  1 
ATOM   2592 N NZ  . LYS A 1 360 ? 60.885 -15.259 -9.819  1.00 39.61 ?  350 LYS A NZ  1 
ATOM   2593 N N   . LYS A 1 361 ? 56.935 -12.283 -6.984  1.00 26.66 ?  351 LYS A N   1 
ATOM   2594 C CA  . LYS A 1 361 ? 57.408 -11.045 -7.642  1.00 28.22 ?  351 LYS A CA  1 
ATOM   2595 C C   . LYS A 1 361 ? 56.415 -10.573 -8.710  1.00 22.94 ?  351 LYS A C   1 
ATOM   2596 O O   . LYS A 1 361 ? 56.725 -10.446 -9.893  1.00 30.37 ?  351 LYS A O   1 
ATOM   2597 C CB  . LYS A 1 361 ? 58.794 -11.248 -8.256  1.00 33.10 ?  351 LYS A CB  1 
ATOM   2598 N N   . ALA A 1 362 ? 55.195 -10.340 -8.277  1.00 24.23 ?  352 ALA A N   1 
ATOM   2599 C CA  . ALA A 1 362 ? 54.110 -10.089 -9.206  1.00 26.66 ?  352 ALA A CA  1 
ATOM   2600 C C   . ALA A 1 362 ? 53.155 -9.113  -8.557  1.00 28.71 ?  352 ALA A C   1 
ATOM   2601 O O   . ALA A 1 362 ? 52.968 -9.131  -7.335  1.00 27.75 ?  352 ALA A O   1 
ATOM   2602 C CB  . ALA A 1 362 ? 53.383 -11.386 -9.587  1.00 27.23 ?  352 ALA A CB  1 
ATOM   2603 N N   . ASP A 1 363 ? 52.537 -8.275  -9.388  1.00 22.53 ?  353 ASP A N   1 
ATOM   2604 C CA  . ASP A 1 363 ? 51.641 -7.213  -8.948  1.00 24.03 ?  353 ASP A CA  1 
ATOM   2605 C C   . ASP A 1 363 ? 50.266 -7.523  -9.524  1.00 32.46 ?  353 ASP A C   1 
ATOM   2606 O O   . ASP A 1 363 ? 50.094 -7.575  -10.750 1.00 28.27 ?  353 ASP A O   1 
ATOM   2607 C CB  . ASP A 1 363 ? 52.194 -5.848  -9.402  1.00 32.25 ?  353 ASP A CB  1 
ATOM   2608 C CG  . ASP A 1 363 ? 51.262 -4.690  -9.117  1.00 43.00 ?  353 ASP A CG  1 
ATOM   2609 O OD1 . ASP A 1 363 ? 51.115 -3.816  -10.003 1.00 62.48 ?  353 ASP A OD1 1 
ATOM   2610 O OD2 . ASP A 1 363 ? 50.674 -4.635  -8.010  1.00 51.94 ?  353 ASP A OD2 1 
ATOM   2611 N N   . LEU A 1 364 ? 49.305 -7.805  -8.645  1.00 22.32 ?  354 LEU A N   1 
ATOM   2612 C CA  . LEU A 1 364 ? 47.935 -8.123  -9.041  1.00 22.38 ?  354 LEU A CA  1 
ATOM   2613 C C   . LEU A 1 364 ? 47.104 -6.899  -8.694  1.00 26.87 ?  354 LEU A C   1 
ATOM   2614 O O   . LEU A 1 364 ? 46.954 -6.578  -7.512  1.00 24.02 ?  354 LEU A O   1 
ATOM   2615 C CB  . LEU A 1 364 ? 47.419 -9.367  -8.309  1.00 22.24 ?  354 LEU A CB  1 
ATOM   2616 C CG  . LEU A 1 364 ? 47.741 -10.723 -8.951  1.00 32.55 ?  354 LEU A CG  1 
ATOM   2617 C CD1 . LEU A 1 364 ? 49.249 -10.914 -9.052  1.00 27.30 ?  354 LEU A CD1 1 
ATOM   2618 C CD2 . LEU A 1 364 ? 47.105 -11.851 -8.155  1.00 30.58 ?  354 LEU A CD2 1 
ATOM   2619 N N   . LYS A 1 365 ? 46.606 -6.184  -9.711  1.00 24.71 ?  355 LYS A N   1 
ATOM   2620 C CA  . LYS A 1 365 ? 45.858 -4.961  -9.407  1.00 26.88 ?  355 LYS A CA  1 
ATOM   2621 C C   . LYS A 1 365 ? 44.471 -5.275  -8.866  1.00 27.91 ?  355 LYS A C   1 
ATOM   2622 O O   . LYS A 1 365 ? 44.035 -6.417  -8.838  1.00 27.45 ?  355 LYS A O   1 
ATOM   2623 C CB  . LYS A 1 365 ? 45.726 -4.050  -10.630 1.00 30.42 ?  355 LYS A CB  1 
ATOM   2624 C CG  . LYS A 1 365 ? 46.975 -3.878  -11.433 1.00 38.02 ?  355 LYS A CG  1 
ATOM   2625 C CD  . LYS A 1 365 ? 47.934 -2.993  -10.700 1.00 41.27 ?  355 LYS A CD  1 
ATOM   2626 C CE  . LYS A 1 365 ? 48.827 -2.263  -11.686 1.00 54.03 ?  355 LYS A CE  1 
ATOM   2627 N NZ  . LYS A 1 365 ? 50.098 -1.828  -11.042 1.00 63.16 ?  355 LYS A NZ  1 
ATOM   2628 N N   . ASP A 1 366 ? 43.765 -4.217  -8.461  1.00 25.38 ?  356 ASP A N   1 
ATOM   2629 C CA  . ASP A 1 366 ? 42.495 -4.356  -7.759  1.00 27.56 ?  356 ASP A CA  1 
ATOM   2630 C C   . ASP A 1 366 ? 41.492 -5.180  -8.562  1.00 27.43 ?  356 ASP A C   1 
ATOM   2631 O O   . ASP A 1 366 ? 41.356 -5.014  -9.777  1.00 26.52 ?  356 ASP A O   1 
ATOM   2632 C CB  . ASP A 1 366 ? 41.903 -2.966  -7.450  1.00 29.05 ?  356 ASP A CB  1 
ATOM   2633 C CG  . ASP A 1 366 ? 42.685 -2.189  -6.375  1.00 41.77 ?  356 ASP A CG  1 
ATOM   2634 O OD1 . ASP A 1 366 ? 43.712 -2.680  -5.836  1.00 31.68 ?  356 ASP A OD1 1 
ATOM   2635 O OD2 . ASP A 1 366 ? 42.259 -1.052  -6.066  1.00 40.61 ?  356 ASP A OD2 1 
ATOM   2636 N N   . GLY A 1 367 ? 40.791 -6.083  -7.873  1.00 20.36 ?  357 GLY A N   1 
ATOM   2637 C CA  . GLY A 1 367 ? 39.760 -6.885  -8.509  1.00 26.88 ?  357 GLY A CA  1 
ATOM   2638 C C   . GLY A 1 367 ? 40.252 -8.066  -9.341  1.00 23.87 ?  357 GLY A C   1 
ATOM   2639 O O   . GLY A 1 367 ? 39.418 -8.819  -9.861  1.00 27.22 ?  357 GLY A O   1 
ATOM   2640 N N   . ALA A 1 368 ? 41.556 -8.235  -9.512  1.00 22.98 ?  358 ALA A N   1 
ATOM   2641 C CA  . ALA A 1 368 ? 42.074 -9.339  -10.323 1.00 26.48 ?  358 ALA A CA  1 
ATOM   2642 C C   . ALA A 1 368 ? 41.770 -10.668 -9.646  1.00 25.74 ?  358 ALA A C   1 
ATOM   2643 O O   . ALA A 1 368 ? 41.774 -10.761 -8.417  1.00 28.88 ?  358 ALA A O   1 
ATOM   2644 C CB  . ALA A 1 368 ? 43.582 -9.207  -10.532 1.00 29.63 ?  358 ALA A CB  1 
ATOM   2645 N N   . LYS A 1 369 ? 41.515 -11.703 -10.450 1.00 26.04 ?  359 LYS A N   1 
ATOM   2646 C CA  . LYS A 1 369 ? 41.162 -13.027 -9.927  1.00 23.25 ?  359 LYS A CA  1 
ATOM   2647 C C   . LYS A 1 369 ? 42.059 -14.096 -10.534 1.00 26.65 ?  359 LYS A C   1 
ATOM   2648 O O   . LYS A 1 369 ? 42.101 -14.262 -11.758 1.00 28.05 ?  359 LYS A O   1 
ATOM   2649 C CB  . LYS A 1 369 ? 39.694 -13.356 -10.205 1.00 26.48 ?  359 LYS A CB  1 
ATOM   2650 N N   . VAL A 1 370 ? 42.762 -14.823 -9.670  1.00 22.27 ?  360 VAL A N   1 
ATOM   2651 C CA  . VAL A 1 370 ? 43.544 -16.002 -10.047 1.00 26.27 ?  360 VAL A CA  1 
ATOM   2652 C C   . VAL A 1 370 ? 43.039 -17.141 -9.156  1.00 27.50 ?  360 VAL A C   1 
ATOM   2653 O O   . VAL A 1 370 ? 43.540 -17.356 -8.051  1.00 28.39 ?  360 VAL A O   1 
ATOM   2654 C CB  . VAL A 1 370 ? 45.047 -15.788 -9.855  1.00 28.10 ?  360 VAL A CB  1 
ATOM   2655 C CG1 . VAL A 1 370 ? 45.835 -16.956 -10.457 1.00 28.09 ?  360 VAL A CG1 1 
ATOM   2656 C CG2 . VAL A 1 370 ? 45.498 -14.413 -10.441 1.00 25.44 ?  360 VAL A CG2 1 
ATOM   2657 N N   . SER A 1 371 ? 42.048 -17.877 -9.623  1.00 25.89 ?  361 SER A N   1 
ATOM   2658 C CA  . SER A 1 371 ? 41.276 -18.722 -8.719  1.00 29.14 ?  361 SER A CA  1 
ATOM   2659 C C   . SER A 1 371 ? 41.797 -20.145 -8.538  1.00 31.72 ?  361 SER A C   1 
ATOM   2660 O O   . SER A 1 371 ? 41.385 -20.796 -7.570  1.00 29.97 ?  361 SER A O   1 
ATOM   2661 C CB  . SER A 1 371 ? 39.818 -18.785 -9.175  1.00 35.66 ?  361 SER A CB  1 
ATOM   2662 O OG  . SER A 1 371 ? 39.153 -17.582 -8.808  1.00 37.90 ?  361 SER A OG  1 
ATOM   2663 N N   . HIS A 1 372 ? 42.655 -20.676 -9.420  1.00 27.87 ?  362 HIS A N   1 
ATOM   2664 C CA  . HIS A 1 372 ? 43.097 -22.045 -9.135  1.00 24.74 ?  362 HIS A CA  1 
ATOM   2665 C C   . HIS A 1 372 ? 44.267 -22.487 -9.990  1.00 28.26 ?  362 HIS A C   1 
ATOM   2666 O O   . HIS A 1 372 ? 44.324 -22.195 -11.188 1.00 27.76 ?  362 HIS A O   1 
ATOM   2667 C CB  . HIS A 1 372 ? 42.001 -23.106 -9.318  1.00 25.73 ?  362 HIS A CB  1 
ATOM   2668 C CG  . HIS A 1 372 ? 40.797 -22.653 -10.095 1.00 35.01 ?  362 HIS A CG  1 
ATOM   2669 N ND1 . HIS A 1 372 ? 39.521 -23.020 -9.729  1.00 37.65 ?  362 HIS A ND1 1 
ATOM   2670 C CD2 . HIS A 1 372 ? 40.657 -21.805 -11.147 1.00 35.82 ?  362 HIS A CD2 1 
ATOM   2671 C CE1 . HIS A 1 372 ? 38.648 -22.461 -10.551 1.00 37.06 ?  362 HIS A CE1 1 
ATOM   2672 N NE2 . HIS A 1 372 ? 39.311 -21.719 -11.421 1.00 36.68 ?  362 HIS A NE2 1 
ATOM   2673 N N   . LEU A 1 373 ? 45.154 -23.252 -9.364  1.00 22.03 ?  363 LEU A N   1 
ATOM   2674 C CA  . LEU A 1 373 ? 46.134 -24.085 -10.075 1.00 25.84 ?  363 LEU A CA  1 
ATOM   2675 C C   . LEU A 1 373 ? 46.969 -23.274 -11.072 1.00 25.14 ?  363 LEU A C   1 
ATOM   2676 O O   . LEU A 1 373 ? 47.257 -23.716 -12.179 1.00 24.29 ?  363 LEU A O   1 
ATOM   2677 C CB  . LEU A 1 373 ? 45.417 -25.269 -10.753 1.00 27.61 ?  363 LEU A CB  1 
ATOM   2678 C CG  . LEU A 1 373 ? 44.779 -26.268 -9.759  1.00 33.33 ?  363 LEU A CG  1 
ATOM   2679 C CD1 . LEU A 1 373 ? 43.554 -27.063 -10.309 1.00 25.02 ?  363 LEU A CD1 1 
ATOM   2680 C CD2 . LEU A 1 373 ? 45.866 -27.248 -9.293  1.00 22.12 ?  363 LEU A CD2 1 
ATOM   2681 N N   . SER A 1 374 ? 47.403 -22.092 -10.665 1.00 22.15 ?  364 SER A N   1 
ATOM   2682 C CA  . SER A 1 374 ? 48.151 -21.199 -11.544 1.00 24.13 ?  364 SER A CA  1 
ATOM   2683 C C   . SER A 1 374 ? 49.442 -20.743 -10.908 1.00 26.62 ?  364 SER A C   1 
ATOM   2684 O O   . SER A 1 374 ? 49.607 -20.761 -9.677  1.00 23.56 ?  364 SER A O   1 
ATOM   2685 C CB  . SER A 1 374 ? 47.311 -19.980 -11.942 1.00 23.67 ?  364 SER A CB  1 
ATOM   2686 O OG  . SER A 1 374 ? 46.140 -20.438 -12.562 1.00 31.41 ?  364 SER A OG  1 
ATOM   2687 N N   . TYR A 1 375 ? 50.374 -20.333 -11.767 1.00 21.29 ?  365 TYR A N   1 
ATOM   2688 C CA  . TYR A 1 375 ? 51.612 -19.714 -11.319 1.00 22.16 ?  365 TYR A CA  1 
ATOM   2689 C C   . TYR A 1 375 ? 51.785 -18.357 -11.984 1.00 23.80 ?  365 TYR A C   1 
ATOM   2690 O O   . TYR A 1 375 ? 51.744 -18.263 -13.217 1.00 25.07 ?  365 TYR A O   1 
ATOM   2691 C CB  . TYR A 1 375 ? 52.839 -20.575 -11.611 1.00 24.80 ?  365 TYR A CB  1 
ATOM   2692 C CG  . TYR A 1 375 ? 54.144 -19.792 -11.354 1.00 28.17 ?  365 TYR A CG  1 
ATOM   2693 C CD1 . TYR A 1 375 ? 54.591 -19.555 -10.061 1.00 25.65 ?  365 TYR A CD1 1 
ATOM   2694 C CD2 . TYR A 1 375 ? 54.907 -19.275 -12.412 1.00 32.99 ?  365 TYR A CD2 1 
ATOM   2695 C CE1 . TYR A 1 375 ? 55.762 -18.843 -9.807  1.00 31.20 ?  365 TYR A CE1 1 
ATOM   2696 C CE2 . TYR A 1 375 ? 56.095 -18.554 -12.169 1.00 36.46 ?  365 TYR A CE2 1 
ATOM   2697 C CZ  . TYR A 1 375 ? 56.513 -18.351 -10.861 1.00 33.05 ?  365 TYR A CZ  1 
ATOM   2698 O OH  . TYR A 1 375 ? 57.670 -17.642 -10.588 1.00 31.67 ?  365 TYR A OH  1 
ATOM   2699 N N   . ILE A 1 376 ? 51.994 -17.317 -11.165 1.00 23.51 ?  366 ILE A N   1 
ATOM   2700 C CA  . ILE A 1 376 ? 52.176 -15.934 -11.630 1.00 27.10 ?  366 ILE A CA  1 
ATOM   2701 C C   . ILE A 1 376 ? 53.509 -15.441 -11.084 1.00 22.88 ?  366 ILE A C   1 
ATOM   2702 O O   . ILE A 1 376 ? 53.653 -15.235 -9.872  1.00 26.60 ?  366 ILE A O   1 
ATOM   2703 C CB  . ILE A 1 376 ? 51.034 -15.003 -11.193 1.00 25.20 ?  366 ILE A CB  1 
ATOM   2704 C CG1 . ILE A 1 376 ? 49.655 -15.610 -11.508 1.00 28.38 ?  366 ILE A CG1 1 
ATOM   2705 C CG2 . ILE A 1 376 ? 51.184 -13.571 -11.862 1.00 24.72 ?  366 ILE A CG2 1 
ATOM   2706 C CD1 . ILE A 1 376 ? 49.352 -15.771 -12.986 1.00 25.73 ?  366 ILE A CD1 1 
ATOM   2707 N N   . GLY A 1 377 ? 54.480 -15.251 -11.960 1.00 27.94 ?  367 GLY A N   1 
ATOM   2708 C CA  . GLY A 1 377 ? 55.810 -14.820 -11.544 1.00 28.56 ?  367 GLY A CA  1 
ATOM   2709 C C   . GLY A 1 377 ? 56.344 -13.726 -12.444 1.00 24.77 ?  367 GLY A C   1 
ATOM   2710 O O   . GLY A 1 377 ? 56.169 -13.769 -13.662 1.00 30.61 ?  367 GLY A O   1 
ATOM   2711 N N   . ASP A 1 378 ? 56.959 -12.722 -11.831 1.00 25.57 ?  368 ASP A N   1 
ATOM   2712 C CA  . ASP A 1 378 ? 57.600 -11.640 -12.594 1.00 33.89 ?  368 ASP A CA  1 
ATOM   2713 C C   . ASP A 1 378 ? 56.611 -10.994 -13.564 1.00 29.62 ?  368 ASP A C   1 
ATOM   2714 O O   . ASP A 1 378 ? 56.833 -10.913 -14.776 1.00 29.74 ?  368 ASP A O   1 
ATOM   2715 C CB  . ASP A 1 378 ? 58.831 -12.169 -13.331 1.00 31.00 ?  368 ASP A CB  1 
ATOM   2716 C CG  . ASP A 1 378 ? 59.888 -12.701 -12.385 1.00 34.53 ?  368 ASP A CG  1 
ATOM   2717 O OD1 . ASP A 1 378 ? 60.377 -11.918 -11.545 1.00 38.16 ?  368 ASP A OD1 1 
ATOM   2718 O OD2 . ASP A 1 378 ? 60.202 -13.906 -12.449 1.00 37.61 ?  368 ASP A OD2 1 
ATOM   2719 N N   . ALA A 1 379 ? 55.493 -10.539 -13.023 1.00 26.38 ?  369 ALA A N   1 
ATOM   2720 C CA  . ALA A 1 379 ? 54.350 -10.268 -13.875 1.00 29.56 ?  369 ALA A CA  1 
ATOM   2721 C C   . ALA A 1 379 ? 53.538 -9.145  -13.269 1.00 30.39 ?  369 ALA A C   1 
ATOM   2722 O O   . ALA A 1 379 ? 53.640 -8.853  -12.070 1.00 26.96 ?  369 ALA A O   1 
ATOM   2723 C CB  . ALA A 1 379 ? 53.491 -11.528 -14.068 1.00 26.02 ?  369 ALA A CB  1 
ATOM   2724 N N   . VAL A 1 380 ? 52.722 -8.525  -14.115 1.00 24.65 ?  370 VAL A N   1 
ATOM   2725 C CA  . VAL A 1 380 ? 51.761 -7.501  -13.715 1.00 23.62 ?  370 VAL A CA  1 
ATOM   2726 C C   . VAL A 1 380 ? 50.416 -7.893  -14.293 1.00 26.08 ?  370 VAL A C   1 
ATOM   2727 O O   . VAL A 1 380 ? 50.309 -8.149  -15.502 1.00 29.01 ?  370 VAL A O   1 
ATOM   2728 C CB  . VAL A 1 380 ? 52.169 -6.089  -14.201 1.00 28.17 ?  370 VAL A CB  1 
ATOM   2729 C CG1 . VAL A 1 380 ? 51.081 -5.064  -13.849 1.00 31.84 ?  370 VAL A CG1 1 
ATOM   2730 C CG2 . VAL A 1 380 ? 53.480 -5.679  -13.599 1.00 31.09 ?  370 VAL A CG2 1 
ATOM   2731 N N   . ILE A 1 381 ? 49.405 -7.992  -13.431 1.00 25.35 ?  371 ILE A N   1 
ATOM   2732 C CA  . ILE A 1 381 ? 48.045 -8.357  -13.822 1.00 25.57 ?  371 ILE A CA  1 
ATOM   2733 C C   . ILE A 1 381 ? 47.128 -7.176  -13.547 1.00 29.48 ?  371 ILE A C   1 
ATOM   2734 O O   . ILE A 1 381 ? 46.938 -6.785  -12.384 1.00 25.22 ?  371 ILE A O   1 
ATOM   2735 C CB  . ILE A 1 381 ? 47.547 -9.607  -13.080 1.00 27.46 ?  371 ILE A CB  1 
ATOM   2736 C CG1 . ILE A 1 381 ? 48.572 -10.746 -13.192 1.00 21.99 ?  371 ILE A CG1 1 
ATOM   2737 C CG2 . ILE A 1 381 ? 46.183 -10.036 -13.612 1.00 27.88 ?  371 ILE A CG2 1 
ATOM   2738 C CD1 . ILE A 1 381 ? 48.916 -11.166 -14.606 1.00 29.25 ?  371 ILE A CD1 1 
ATOM   2739 N N   . GLY A 1 382 ? 46.513 -6.644  -14.611 1.00 22.51 ?  372 GLY A N   1 
ATOM   2740 C CA  . GLY A 1 382 ? 45.728 -5.411  -14.501 1.00 22.40 ?  372 GLY A CA  1 
ATOM   2741 C C   . GLY A 1 382 ? 44.416 -5.582  -13.758 1.00 24.41 ?  372 GLY A C   1 
ATOM   2742 O O   . GLY A 1 382 ? 43.988 -6.686  -13.436 1.00 28.79 ?  372 GLY A O   1 
ATOM   2743 N N   . GLU A 1 383 ? 43.762 -4.444  -13.494 1.00 22.16 ?  373 GLU A N   1 
ATOM   2744 C CA  . GLU A 1 383 ? 42.508 -4.417  -12.744 1.00 23.42 ?  373 GLU A CA  1 
ATOM   2745 C C   . GLU A 1 383 ? 41.443 -5.319  -13.367 1.00 27.92 ?  373 GLU A C   1 
ATOM   2746 O O   . GLU A 1 383 ? 41.250 -5.329  -14.583 1.00 26.11 ?  373 GLU A O   1 
ATOM   2747 C CB  . GLU A 1 383 ? 41.976 -2.986  -12.653 1.00 25.78 ?  373 GLU A CB  1 
ATOM   2748 C CG  . GLU A 1 383 ? 42.777 -2.073  -11.702 1.00 29.46 ?  373 GLU A CG  1 
ATOM   2749 C CD  . GLU A 1 383 ? 43.919 -1.328  -12.385 1.00 38.06 ?  373 GLU A CD  1 
ATOM   2750 O OE1 . GLU A 1 383 ? 44.287 -1.684  -13.527 1.00 35.95 ?  373 GLU A OE1 1 
ATOM   2751 O OE2 . GLU A 1 383 ? 44.479 -0.401  -11.762 1.00 51.15 ?  373 GLU A OE2 1 
ATOM   2752 N N   . ARG A 1 384 ? 40.770 -6.088  -12.515 1.00 23.84 ?  374 ARG A N   1 
ATOM   2753 C CA  . ARG A 1 384 ? 39.605 -6.907  -12.842 1.00 28.63 ?  374 ARG A CA  1 
ATOM   2754 C C   . ARG A 1 384 ? 39.912 -8.008  -13.857 1.00 24.37 ?  374 ARG A C   1 
ATOM   2755 O O   . ARG A 1 384 ? 38.995 -8.658  -14.355 1.00 30.81 ?  374 ARG A O   1 
ATOM   2756 C CB  . ARG A 1 384 ? 38.451 -6.018  -13.333 1.00 30.38 ?  374 ARG A CB  1 
ATOM   2757 C CG  . ARG A 1 384 ? 38.036 -4.905  -12.306 1.00 28.78 ?  374 ARG A CG  1 
ATOM   2758 C CD  . ARG A 1 384 ? 36.956 -4.066  -12.926 1.00 30.63 ?  374 ARG A CD  1 
ATOM   2759 N NE  . ARG A 1 384 ? 37.505 -3.150  -13.927 1.00 37.03 ?  374 ARG A NE  1 
ATOM   2760 C CZ  . ARG A 1 384 ? 38.388 -2.180  -13.710 1.00 37.33 ?  374 ARG A CZ  1 
ATOM   2761 N NH1 . ARG A 1 384 ? 38.638 -1.727  -12.494 1.00 33.80 ?  374 ARG A NH1 1 
ATOM   2762 N NH2 . ARG A 1 384 ? 38.990 -1.604  -14.750 1.00 31.89 ?  374 ARG A NH2 1 
ATOM   2763 N N   . THR A 1 385 ? 41.171 -8.250  -14.171 1.00 23.65 ?  375 THR A N   1 
ATOM   2764 C CA  . THR A 1 385 ? 41.497 -9.298  -15.125 1.00 29.91 ?  375 THR A CA  1 
ATOM   2765 C C   . THR A 1 385 ? 41.349 -10.672 -14.484 1.00 31.82 ?  375 THR A C   1 
ATOM   2766 O O   . THR A 1 385 ? 41.656 -10.860 -13.296 1.00 27.06 ?  375 THR A O   1 
ATOM   2767 C CB  . THR A 1 385 ? 42.901 -9.078  -15.685 1.00 27.57 ?  375 THR A CB  1 
ATOM   2768 O OG1 . THR A 1 385 ? 42.830 -8.055  -16.689 1.00 33.12 ?  375 THR A OG1 1 
ATOM   2769 C CG2 . THR A 1 385 ? 43.501 -10.342 -16.293 1.00 27.01 ?  375 THR A CG2 1 
ATOM   2770 N N   . ASN A 1 386 ? 40.829 -11.612 -15.269 1.00 26.00 ?  376 ASN A N   1 
ATOM   2771 C CA  . ASN A 1 386 ? 40.577 -12.988 -14.831 1.00 28.67 ?  376 ASN A CA  1 
ATOM   2772 C C   . ASN A 1 386 ? 41.614 -13.927 -15.437 1.00 28.50 ?  376 ASN A C   1 
ATOM   2773 O O   . ASN A 1 386 ? 41.776 -13.978 -16.665 1.00 28.38 ?  376 ASN A O   1 
ATOM   2774 C CB  . ASN A 1 386 ? 39.169 -13.431 -15.232 1.00 28.67 ?  376 ASN A CB  1 
ATOM   2775 C CG  . ASN A 1 386 ? 38.723 -14.695 -14.500 1.00 53.31 ?  376 ASN A CG  1 
ATOM   2776 O OD1 . ASN A 1 386 ? 38.202 -14.618 -13.383 1.00 53.35 ?  376 ASN A OD1 1 
ATOM   2777 N ND2 . ASN A 1 386 ? 38.930 -15.867 -15.123 1.00 47.80 ?  376 ASN A ND2 1 
ATOM   2778 N N   . ILE A 1 387 ? 42.315 -14.659 -14.588 1.00 23.88 ?  377 ILE A N   1 
ATOM   2779 C CA  . ILE A 1 387 ? 43.312 -15.617 -15.035 1.00 24.13 ?  377 ILE A CA  1 
ATOM   2780 C C   . ILE A 1 387 ? 42.711 -17.007 -14.835 1.00 32.75 ?  377 ILE A C   1 
ATOM   2781 O O   . ILE A 1 387 ? 42.450 -17.424 -13.699 1.00 27.78 ?  377 ILE A O   1 
ATOM   2782 C CB  . ILE A 1 387 ? 44.635 -15.460 -14.274 1.00 26.44 ?  377 ILE A CB  1 
ATOM   2783 C CG1 . ILE A 1 387 ? 45.218 -14.046 -14.431 1.00 26.46 ?  377 ILE A CG1 1 
ATOM   2784 C CG2 . ILE A 1 387 ? 45.628 -16.498 -14.703 1.00 25.68 ?  377 ILE A CG2 1 
ATOM   2785 C CD1 . ILE A 1 387 ? 45.567 -13.651 -15.846 1.00 27.37 ?  377 ILE A CD1 1 
ATOM   2786 N N   . GLY A 1 388 ? 42.474 -17.720 -15.925 1.00 27.39 ?  378 GLY A N   1 
ATOM   2787 C CA  . GLY A 1 388 ? 41.805 -19.007 -15.842 1.00 28.13 ?  378 GLY A CA  1 
ATOM   2788 C C   . GLY A 1 388 ? 42.626 -20.056 -15.119 1.00 29.52 ?  378 GLY A C   1 
ATOM   2789 O O   . GLY A 1 388 ? 43.814 -19.892 -14.846 1.00 28.37 ?  378 GLY A O   1 
ATOM   2790 N N   . CYS A 1 389 ? 41.958 -21.159 -14.778 1.00 25.38 ?  379 CYS A N   1 
ATOM   2791 C CA  . CYS A 1 389 ? 42.620 -22.287 -14.115 1.00 25.66 ?  379 CYS A CA  1 
ATOM   2792 C C   . CYS A 1 389 ? 43.759 -22.858 -14.958 1.00 28.58 ?  379 CYS A C   1 
ATOM   2793 O O   . CYS A 1 389 ? 43.665 -22.939 -16.189 1.00 25.19 ?  379 CYS A O   1 
ATOM   2794 C CB  . CYS A 1 389 ? 41.566 -23.387 -13.867 1.00 31.10 ?  379 CYS A CB  1 
ATOM   2795 S SG  . CYS A 1 389 ? 42.118 -24.872 -12.974 1.00 31.15 ?  379 CYS A SG  1 
ATOM   2796 N N   . GLY A 1 390 ? 44.829 -23.292 -14.293 1.00 23.58 ?  380 GLY A N   1 
ATOM   2797 C CA  . GLY A 1 390 ? 45.932 -23.966 -14.971 1.00 29.29 ?  380 GLY A CA  1 
ATOM   2798 C C   . GLY A 1 390 ? 46.858 -23.075 -15.782 1.00 30.63 ?  380 GLY A C   1 
ATOM   2799 O O   . GLY A 1 390 ? 47.690 -23.588 -16.547 1.00 28.37 ?  380 GLY A O   1 
ATOM   2800 N N   . THR A 1 391 ? 46.745 -21.766 -15.646 1.00 25.11 ?  381 THR A N   1 
ATOM   2801 C CA  . THR A 1 391 ? 47.499 -20.835 -16.474 1.00 29.32 ?  381 THR A CA  1 
ATOM   2802 C C   . THR A 1 391 ? 48.841 -20.456 -15.850 1.00 24.74 ?  381 THR A C   1 
ATOM   2803 O O   . THR A 1 391 ? 49.014 -20.439 -14.624 1.00 27.54 ?  381 THR A O   1 
ATOM   2804 C CB  . THR A 1 391 ? 46.613 -19.637 -16.760 1.00 30.73 ?  381 THR A CB  1 
ATOM   2805 O OG1 . THR A 1 391 ? 45.556 -20.098 -17.614 1.00 34.89 ?  381 THR A OG1 1 
ATOM   2806 C CG2 . THR A 1 391 ? 47.371 -18.469 -17.433 1.00 31.33 ?  381 THR A CG2 1 
ATOM   2807 N N   . ILE A 1 392 ? 49.829 -20.230 -16.707 1.00 22.99 ?  382 ILE A N   1 
ATOM   2808 C CA  . ILE A 1 392 ? 51.201 -20.032 -16.241 1.00 20.76 ?  382 ILE A CA  1 
ATOM   2809 C C   . ILE A 1 392 ? 51.871 -18.859 -16.942 1.00 26.68 ?  382 ILE A C   1 
ATOM   2810 O O   . ILE A 1 392 ? 51.877 -18.790 -18.178 1.00 28.14 ?  382 ILE A O   1 
ATOM   2811 C CB  . ILE A 1 392 ? 52.045 -21.305 -16.453 1.00 28.12 ?  382 ILE A CB  1 
ATOM   2812 C CG1 . ILE A 1 392 ? 51.345 -22.532 -15.858 1.00 29.48 ?  382 ILE A CG1 1 
ATOM   2813 C CG2 . ILE A 1 392 ? 53.431 -21.124 -15.917 1.00 29.16 ?  382 ILE A CG2 1 
ATOM   2814 C CD1 . ILE A 1 392 ? 51.701 -23.830 -16.543 1.00 31.37 ?  382 ILE A CD1 1 
ATOM   2815 N N   . THR A 1 393 ? 52.489 -17.973 -16.159 1.00 26.43 ?  383 THR A N   1 
ATOM   2816 C CA  . THR A 1 393 ? 53.515 -17.061 -16.683 1.00 25.85 ?  383 THR A CA  1 
ATOM   2817 C C   . THR A 1 393 ? 54.836 -17.808 -16.812 1.00 34.19 ?  383 THR A C   1 
ATOM   2818 O O   . THR A 1 393 ? 55.488 -18.127 -15.808 1.00 32.97 ?  383 THR A O   1 
ATOM   2819 C CB  . THR A 1 393 ? 53.686 -15.838 -15.790 1.00 26.76 ?  383 THR A CB  1 
ATOM   2820 O OG1 . THR A 1 393 ? 54.183 -16.258 -14.506 1.00 31.93 ?  383 THR A OG1 1 
ATOM   2821 C CG2 . THR A 1 393 ? 52.367 -15.112 -15.658 1.00 27.53 ?  383 THR A CG2 1 
ATOM   2822 N N   . VAL A 1 394 ? 55.239 -18.078 -18.055 1.00 27.32 ?  384 VAL A N   1 
ATOM   2823 C CA  . VAL A 1 394 ? 56.463 -18.828 -18.323 1.00 30.00 ?  384 VAL A CA  1 
ATOM   2824 C C   . VAL A 1 394 ? 57.648 -17.864 -18.285 1.00 34.00 ?  384 VAL A C   1 
ATOM   2825 O O   . VAL A 1 394 ? 58.036 -17.294 -19.318 1.00 28.42 ?  384 VAL A O   1 
ATOM   2826 C CB  . VAL A 1 394 ? 56.366 -19.546 -19.675 1.00 38.32 ?  384 VAL A CB  1 
ATOM   2827 C CG1 . VAL A 1 394 ? 57.579 -20.420 -19.881 1.00 32.52 ?  384 VAL A CG1 1 
ATOM   2828 C CG2 . VAL A 1 394 ? 55.034 -20.339 -19.773 1.00 32.58 ?  384 VAL A CG2 1 
ATOM   2829 N N   . ASN A 1 395 ? 58.229 -17.668 -17.089 1.00 32.66 ?  385 ASN A N   1 
ATOM   2830 C CA  . ASN A 1 395 ? 59.116 -16.534 -16.846 1.00 35.67 ?  385 ASN A CA  1 
ATOM   2831 C C   . ASN A 1 395 ? 60.596 -16.879 -16.940 1.00 38.81 ?  385 ASN A C   1 
ATOM   2832 O O   . ASN A 1 395 ? 61.411 -15.969 -17.102 1.00 44.71 ?  385 ASN A O   1 
ATOM   2833 C CB  . ASN A 1 395 ? 58.860 -15.911 -15.458 1.00 34.17 ?  385 ASN A CB  1 
ATOM   2834 C CG  . ASN A 1 395 ? 58.896 -16.944 -14.336 1.00 38.52 ?  385 ASN A CG  1 
ATOM   2835 O OD1 . ASN A 1 395 ? 58.876 -18.157 -14.581 1.00 35.61 ?  385 ASN A OD1 1 
ATOM   2836 N ND2 . ASN A 1 395 ? 59.037 -16.466 -13.098 1.00 40.67 ?  385 ASN A ND2 1 
ATOM   2837 N N   . TYR A 1 396 ? 60.959 -18.156 -16.873 1.00 37.70 ?  386 TYR A N   1 
ATOM   2838 C CA  . TYR A 1 396 ? 62.347 -18.587 -16.779 1.00 43.06 ?  386 TYR A CA  1 
ATOM   2839 C C   . TYR A 1 396 ? 62.695 -19.423 -18.002 1.00 43.73 ?  386 TYR A C   1 
ATOM   2840 O O   . TYR A 1 396 ? 61.938 -20.325 -18.376 1.00 42.06 ?  386 TYR A O   1 
ATOM   2841 C CB  . TYR A 1 396 ? 62.559 -19.389 -15.491 1.00 43.86 ?  386 TYR A CB  1 
ATOM   2842 C CG  . TYR A 1 396 ? 63.973 -19.851 -15.228 1.00 53.31 ?  386 TYR A CG  1 
ATOM   2843 C CD1 . TYR A 1 396 ? 65.042 -18.962 -15.281 1.00 52.60 ?  386 TYR A CD1 1 
ATOM   2844 C CD2 . TYR A 1 396 ? 64.238 -21.185 -14.909 1.00 51.99 ?  386 TYR A CD2 1 
ATOM   2845 C CE1 . TYR A 1 396 ? 66.341 -19.386 -15.026 1.00 53.42 ?  386 TYR A CE1 1 
ATOM   2846 C CE2 . TYR A 1 396 ? 65.535 -21.620 -14.653 1.00 59.10 ?  386 TYR A CE2 1 
ATOM   2847 C CZ  . TYR A 1 396 ? 66.582 -20.718 -14.716 1.00 62.93 ?  386 TYR A CZ  1 
ATOM   2848 O OH  . TYR A 1 396 ? 67.872 -21.142 -14.471 1.00 61.83 ?  386 TYR A OH  1 
ATOM   2849 N N   . ASP A 1 397 ? 63.836 -19.126 -18.625 1.00 49.49 ?  387 ASP A N   1 
ATOM   2850 C CA  . ASP A 1 397 ? 64.263 -19.840 -19.823 1.00 52.60 ?  387 ASP A CA  1 
ATOM   2851 C C   . ASP A 1 397 ? 65.500 -20.697 -19.578 1.00 50.54 ?  387 ASP A C   1 
ATOM   2852 O O   . ASP A 1 397 ? 66.138 -21.145 -20.535 1.00 61.72 ?  387 ASP A O   1 
ATOM   2853 C CB  . ASP A 1 397 ? 64.489 -18.850 -20.970 1.00 46.08 ?  387 ASP A CB  1 
ATOM   2854 C CG  . ASP A 1 397 ? 65.815 -18.087 -20.868 1.00 55.18 ?  387 ASP A CG  1 
ATOM   2855 O OD1 . ASP A 1 397 ? 66.445 -18.042 -19.789 1.00 48.22 ?  387 ASP A OD1 1 
ATOM   2856 O OD2 . ASP A 1 397 ? 66.194 -17.455 -21.879 1.00 62.89 -1 387 ASP A OD2 1 
ATOM   2857 N N   . GLY A 1 398 ? 65.838 -20.952 -18.315 1.00 49.96 ?  388 GLY A N   1 
ATOM   2858 C CA  . GLY A 1 398 ? 67.058 -21.646 -17.978 1.00 57.33 ?  388 GLY A CA  1 
ATOM   2859 C C   . GLY A 1 398 ? 68.283 -20.766 -17.916 1.00 61.81 ?  388 GLY A C   1 
ATOM   2860 O O   . GLY A 1 398 ? 69.375 -21.266 -17.610 1.00 58.96 ?  388 GLY A O   1 
ATOM   2861 N N   . GLU A 1 399 ? 68.139 -19.473 -18.197 1.00 57.98 ?  389 GLU A N   1 
ATOM   2862 C CA  . GLU A 1 399 ? 69.257 -18.542 -18.154 1.00 68.02 ?  389 GLU A CA  1 
ATOM   2863 C C   . GLU A 1 399 ? 68.844 -17.256 -17.444 1.00 58.81 ?  389 GLU A C   1 
ATOM   2864 O O   . GLU A 1 399 ? 69.539 -16.789 -16.537 1.00 56.97 ?  389 GLU A O   1 
ATOM   2865 C CB  . GLU A 1 399 ? 69.759 -18.246 -19.572 1.00 68.01 ?  389 GLU A CB  1 
ATOM   2866 C CG  . GLU A 1 399 ? 70.817 -19.220 -20.079 1.00 72.20 ?  389 GLU A CG  1 
ATOM   2867 C CD  . GLU A 1 399 ? 72.221 -18.633 -20.027 1.00 80.84 ?  389 GLU A CD  1 
ATOM   2868 O OE1 . GLU A 1 399 ? 72.356 -17.445 -19.654 1.00 81.57 ?  389 GLU A OE1 1 
ATOM   2869 O OE2 . GLU A 1 399 ? 73.188 -19.358 -20.355 1.00 84.08 ?  389 GLU A OE2 1 
ATOM   2870 N N   . ASN A 1 400 ? 67.705 -16.689 -17.839 1.00 50.33 ?  390 ASN A N   1 
ATOM   2871 C CA  . ASN A 1 400 ? 67.225 -15.428 -17.292 1.00 51.00 ?  390 ASN A CA  1 
ATOM   2872 C C   . ASN A 1 400 ? 65.741 -15.534 -16.954 1.00 53.10 ?  390 ASN A C   1 
ATOM   2873 O O   . ASN A 1 400 ? 65.064 -16.515 -17.285 1.00 50.15 ?  390 ASN A O   1 
ATOM   2874 C CB  . ASN A 1 400 ? 67.463 -14.281 -18.283 1.00 52.86 ?  390 ASN A CB  1 
ATOM   2875 C CG  . ASN A 1 400 ? 68.934 -14.086 -18.599 1.00 65.64 ?  390 ASN A CG  1 
ATOM   2876 O OD1 . ASN A 1 400 ? 69.671 -13.487 -17.819 1.00 57.03 ?  390 ASN A OD1 1 
ATOM   2877 N ND2 . ASN A 1 400 ? 69.372 -14.612 -19.739 1.00 66.93 ?  390 ASN A ND2 1 
ATOM   2878 N N   . LYS A 1 401 ? 65.237 -14.506 -16.279 1.00 38.24 ?  391 LYS A N   1 
ATOM   2879 C CA  . LYS A 1 401 ? 63.818 -14.378 -15.991 1.00 40.66 ?  391 LYS A CA  1 
ATOM   2880 C C   . LYS A 1 401 ? 63.264 -13.190 -16.764 1.00 47.05 ?  391 LYS A C   1 
ATOM   2881 O O   . LYS A 1 401 ? 63.924 -12.151 -16.877 1.00 51.51 ?  391 LYS A O   1 
ATOM   2882 C CB  . LYS A 1 401 ? 63.566 -14.220 -14.488 1.00 44.06 ?  391 LYS A CB  1 
ATOM   2883 C CG  . LYS A 1 401 ? 64.348 -15.215 -13.625 1.00 47.31 ?  391 LYS A CG  1 
ATOM   2884 C CD  . LYS A 1 401 ? 63.541 -15.764 -12.454 1.00 42.16 ?  391 LYS A CD  1 
ATOM   2885 C CE  . LYS A 1 401 ? 64.108 -17.108 -11.983 1.00 48.94 ?  391 LYS A CE  1 
ATOM   2886 N NZ  . LYS A 1 401 ? 63.865 -17.319 -10.532 1.00 47.57 ?  391 LYS A NZ  1 
ATOM   2887 N N   . PHE A 1 402 ? 62.060 -13.351 -17.309 1.00 34.75 ?  392 PHE A N   1 
ATOM   2888 C CA  . PHE A 1 402 ? 61.451 -12.353 -18.178 1.00 36.26 ?  392 PHE A CA  1 
ATOM   2889 C C   . PHE A 1 402 ? 60.043 -12.012 -17.700 1.00 42.28 ?  392 PHE A C   1 
ATOM   2890 O O   . PHE A 1 402 ? 59.364 -12.835 -17.075 1.00 36.45 ?  392 PHE A O   1 
ATOM   2891 C CB  . PHE A 1 402 ? 61.417 -12.854 -19.617 1.00 36.56 ?  392 PHE A CB  1 
ATOM   2892 C CG  . PHE A 1 402 ? 62.786 -13.099 -20.197 1.00 41.45 ?  392 PHE A CG  1 
ATOM   2893 C CD1 . PHE A 1 402 ? 63.543 -12.039 -20.667 1.00 46.60 ?  392 PHE A CD1 1 
ATOM   2894 C CD2 . PHE A 1 402 ? 63.315 -14.382 -20.261 1.00 46.66 ?  392 PHE A CD2 1 
ATOM   2895 C CE1 . PHE A 1 402 ? 64.808 -12.257 -21.193 1.00 52.37 ?  392 PHE A CE1 1 
ATOM   2896 C CE2 . PHE A 1 402 ? 64.576 -14.611 -20.788 1.00 49.65 ?  392 PHE A CE2 1 
ATOM   2897 C CZ  . PHE A 1 402 ? 65.321 -13.548 -21.252 1.00 56.96 ?  392 PHE A CZ  1 
ATOM   2898 N N   . LYS A 1 403 ? 59.596 -10.803 -18.037 1.00 34.39 ?  393 LYS A N   1 
ATOM   2899 C CA  . LYS A 1 403 ? 58.385 -10.241 -17.457 1.00 43.70 ?  393 LYS A CA  1 
ATOM   2900 C C   . LYS A 1 403 ? 57.160 -10.461 -18.346 1.00 34.67 ?  393 LYS A C   1 
ATOM   2901 O O   . LYS A 1 403 ? 57.242 -10.484 -19.576 1.00 37.49 ?  393 LYS A O   1 
ATOM   2902 C CB  . LYS A 1 403 ? 58.576 -8.743  -17.178 1.00 38.55 ?  393 LYS A CB  1 
ATOM   2903 N N   . THR A 1 404 ? 56.013 -10.605 -17.701 1.00 28.16 ?  394 THR A N   1 
ATOM   2904 C CA  . THR A 1 404 ? 54.729 -10.735 -18.373 1.00 34.07 ?  394 THR A CA  1 
ATOM   2905 C C   . THR A 1 404 ? 53.828 -9.582  -17.953 1.00 31.63 ?  394 THR A C   1 
ATOM   2906 O O   . THR A 1 404 ? 53.696 -9.298  -16.759 1.00 30.08 ?  394 THR A O   1 
ATOM   2907 C CB  . THR A 1 404 ? 54.064 -12.074 -18.012 1.00 33.83 ?  394 THR A CB  1 
ATOM   2908 O OG1 . THR A 1 404 ? 54.911 -13.167 -18.403 1.00 32.54 ?  394 THR A OG1 1 
ATOM   2909 C CG2 . THR A 1 404 ? 52.748 -12.197 -18.737 1.00 31.91 ?  394 THR A CG2 1 
ATOM   2910 N N   . ILE A 1 405 ? 53.177 -8.936  -18.914 1.00 27.09 ?  395 ILE A N   1 
ATOM   2911 C CA  . ILE A 1 405 ? 52.239 -7.861  -18.607 1.00 26.13 ?  395 ILE A CA  1 
ATOM   2912 C C   . ILE A 1 405 ? 50.873 -8.256  -19.137 1.00 29.72 ?  395 ILE A C   1 
ATOM   2913 O O   . ILE A 1 405 ? 50.720 -8.555  -20.327 1.00 27.99 ?  395 ILE A O   1 
ATOM   2914 C CB  . ILE A 1 405 ? 52.684 -6.517  -19.216 1.00 33.40 ?  395 ILE A CB  1 
ATOM   2915 C CG1 . ILE A 1 405 ? 53.961 -6.028  -18.557 1.00 34.81 ?  395 ILE A CG1 1 
ATOM   2916 C CG2 . ILE A 1 405 ? 51.595 -5.467  -19.058 1.00 32.09 ?  395 ILE A CG2 1 
ATOM   2917 C CD1 . ILE A 1 405 ? 54.669 -4.932  -19.374 1.00 46.71 ?  395 ILE A CD1 1 
ATOM   2918 N N   . VAL A 1 406 ? 49.876 -8.258  -18.266 1.00 27.44 ?  396 VAL A N   1 
ATOM   2919 C CA  . VAL A 1 406 ? 48.506 -8.467  -18.696 1.00 28.29 ?  396 VAL A CA  1 
ATOM   2920 C C   . VAL A 1 406 ? 47.727 -7.212  -18.362 1.00 30.84 ?  396 VAL A C   1 
ATOM   2921 O O   . VAL A 1 406 ? 47.817 -6.700  -17.239 1.00 29.67 ?  396 VAL A O   1 
ATOM   2922 C CB  . VAL A 1 406 ? 47.888 -9.715  -18.044 1.00 27.61 ?  396 VAL A CB  1 
ATOM   2923 C CG1 . VAL A 1 406 ? 46.462 -9.912  -18.525 1.00 28.15 ?  396 VAL A CG1 1 
ATOM   2924 C CG2 . VAL A 1 406 ? 48.761 -10.948 -18.342 1.00 24.98 ?  396 VAL A CG2 1 
ATOM   2925 N N   . GLY A 1 407 ? 46.971 -6.712  -19.333 1.00 28.73 ?  397 GLY A N   1 
ATOM   2926 C CA  . GLY A 1 407 ? 46.198 -5.495  -19.143 1.00 31.18 ?  397 GLY A CA  1 
ATOM   2927 C C   . GLY A 1 407 ? 44.984 -5.690  -18.246 1.00 32.22 ?  397 GLY A C   1 
ATOM   2928 O O   . GLY A 1 407 ? 44.815 -6.698  -17.556 1.00 37.18 ?  397 GLY A O   1 
ATOM   2929 N N   . LYS A 1 408 ? 44.111 -4.688  -18.266 1.00 26.49 ?  398 LYS A N   1 
ATOM   2930 C CA  . LYS A 1 408 ? 42.928 -4.695  -17.419 1.00 30.11 ?  398 LYS A CA  1 
ATOM   2931 C C   . LYS A 1 408 ? 41.695 -5.216  -18.161 1.00 27.51 ?  398 LYS A C   1 
ATOM   2932 O O   . LYS A 1 408 ? 41.607 -5.142  -19.383 1.00 30.48 ?  398 LYS A O   1 
ATOM   2933 C CB  . LYS A 1 408 ? 42.682 -3.296  -16.865 1.00 29.95 ?  398 LYS A CB  1 
ATOM   2934 C CG  . LYS A 1 408 ? 42.109 -2.321  -17.823 1.00 39.73 ?  398 LYS A CG  1 
ATOM   2935 C CD  . LYS A 1 408 ? 42.043 -0.948  -17.172 1.00 39.79 ?  398 LYS A CD  1 
ATOM   2936 C CE  . LYS A 1 408 ? 42.316 0.135   -18.204 1.00 55.86 ?  398 LYS A CE  1 
ATOM   2937 N NZ  . LYS A 1 408 ? 41.038 0.787   -18.650 1.00 54.43 ?  398 LYS A NZ  1 
ATOM   2938 N N   . ASP A 1 409 ? 40.765 -5.790  -17.402 1.00 24.17 ?  399 ASP A N   1 
ATOM   2939 C CA  . ASP A 1 409 ? 39.502 -6.315  -17.929 1.00 30.36 ?  399 ASP A CA  1 
ATOM   2940 C C   . ASP A 1 409 ? 39.746 -7.370  -18.999 1.00 35.64 ?  399 ASP A C   1 
ATOM   2941 O O   . ASP A 1 409 ? 39.041 -7.435  -20.007 1.00 32.21 ?  399 ASP A O   1 
ATOM   2942 C CB  . ASP A 1 409 ? 38.614 -5.189  -18.487 1.00 35.31 ?  399 ASP A CB  1 
ATOM   2943 C CG  . ASP A 1 409 ? 38.216 -4.178  -17.428 1.00 36.60 ?  399 ASP A CG  1 
ATOM   2944 O OD1 . ASP A 1 409 ? 37.524 -4.566  -16.460 1.00 34.09 ?  399 ASP A OD1 1 
ATOM   2945 O OD2 . ASP A 1 409 ? 38.624 -3.002  -17.544 1.00 36.78 ?  399 ASP A OD2 1 
ATOM   2946 N N   . SER A 1 410 ? 40.778 -8.167  -18.815 1.00 24.17 ?  400 SER A N   1 
ATOM   2947 C CA  . SER A 1 410 ? 41.090 -9.216  -19.767 1.00 29.02 ?  400 SER A CA  1 
ATOM   2948 C C   . SER A 1 410 ? 40.706 -10.561 -19.184 1.00 28.59 ?  400 SER A C   1 
ATOM   2949 O O   . SER A 1 410 ? 40.415 -10.681 -17.992 1.00 26.70 ?  400 SER A O   1 
ATOM   2950 C CB  . SER A 1 410 ? 42.569 -9.168  -20.169 1.00 31.41 ?  400 SER A CB  1 
ATOM   2951 O OG  . SER A 1 410 ? 42.762 -8.036  -21.010 1.00 31.03 ?  400 SER A OG  1 
ATOM   2952 N N   . PHE A 1 411 ? 40.645 -11.560 -20.065 1.00 27.27 ?  401 PHE A N   1 
ATOM   2953 C CA  . PHE A 1 411 ? 40.170 -12.908 -19.742 1.00 25.50 ?  401 PHE A CA  1 
ATOM   2954 C C   . PHE A 1 411 ? 41.173 -13.895 -20.315 1.00 28.92 ?  401 PHE A C   1 
ATOM   2955 O O   . PHE A 1 411 ? 41.161 -14.170 -21.516 1.00 30.91 ?  401 PHE A O   1 
ATOM   2956 C CB  . PHE A 1 411 ? 38.768 -13.136 -20.300 1.00 33.25 ?  401 PHE A CB  1 
ATOM   2957 C CG  . PHE A 1 411 ? 37.973 -14.137 -19.527 1.00 41.76 ?  401 PHE A CG  1 
ATOM   2958 C CD1 . PHE A 1 411 ? 37.259 -13.757 -18.405 1.00 48.98 ?  401 PHE A CD1 1 
ATOM   2959 C CD2 . PHE A 1 411 ? 37.933 -15.468 -19.931 1.00 51.05 ?  401 PHE A CD2 1 
ATOM   2960 C CE1 . PHE A 1 411 ? 36.532 -14.693 -17.677 1.00 56.00 ?  401 PHE A CE1 1 
ATOM   2961 C CE2 . PHE A 1 411 ? 37.195 -16.406 -19.219 1.00 54.79 ?  401 PHE A CE2 1 
ATOM   2962 C CZ  . PHE A 1 411 ? 36.494 -16.018 -18.089 1.00 54.61 ?  401 PHE A CZ  1 
ATOM   2963 N N   . VAL A 1 412 ? 42.085 -14.383 -19.489 1.00 26.01 ?  402 VAL A N   1 
ATOM   2964 C CA  . VAL A 1 412 ? 43.050 -15.376 -19.944 1.00 26.58 ?  402 VAL A CA  1 
ATOM   2965 C C   . VAL A 1 412 ? 42.470 -16.748 -19.648 1.00 29.85 ?  402 VAL A C   1 
ATOM   2966 O O   . VAL A 1 412 ? 42.226 -17.094 -18.483 1.00 27.93 ?  402 VAL A O   1 
ATOM   2967 C CB  . VAL A 1 412 ? 44.418 -15.184 -19.279 1.00 21.98 ?  402 VAL A CB  1 
ATOM   2968 C CG1 . VAL A 1 412 ? 45.452 -16.169 -19.862 1.00 27.46 ?  402 VAL A CG1 1 
ATOM   2969 C CG2 . VAL A 1 412 ? 44.900 -13.789 -19.515 1.00 28.62 ?  402 VAL A CG2 1 
ATOM   2970 N N   . GLY A 1 413 ? 42.235 -17.520 -20.701 1.00 29.31 ?  403 GLY A N   1 
ATOM   2971 C CA  . GLY A 1 413 ? 41.571 -18.792 -20.572 1.00 28.83 ?  403 GLY A CA  1 
ATOM   2972 C C   . GLY A 1 413 ? 42.404 -19.797 -19.801 1.00 27.57 ?  403 GLY A C   1 
ATOM   2973 O O   . GLY A 1 413 ? 43.551 -19.560 -19.426 1.00 26.81 ?  403 GLY A O   1 
ATOM   2974 N N   . CYS A 1 414 ? 41.809 -20.970 -19.614 1.00 25.53 ?  404 CYS A N   1 
ATOM   2975 C CA  . CYS A 1 414 ? 42.412 -22.056 -18.847 1.00 26.78 ?  404 CYS A CA  1 
ATOM   2976 C C   . CYS A 1 414 ? 43.563 -22.701 -19.597 1.00 28.31 ?  404 CYS A C   1 
ATOM   2977 O O   . CYS A 1 414 ? 43.547 -22.816 -20.831 1.00 26.58 ?  404 CYS A O   1 
ATOM   2978 C CB  . CYS A 1 414 ? 41.370 -23.142 -18.569 1.00 30.03 ?  404 CYS A CB  1 
ATOM   2979 S SG  . CYS A 1 414 ? 40.077 -22.597 -17.509 1.00 37.24 ?  404 CYS A SG  1 
ATOM   2980 N N   . ASN A 1 415 ? 44.550 -23.155 -18.832 1.00 22.83 ?  405 ASN A N   1 
ATOM   2981 C CA  . ASN A 1 415 ? 45.703 -23.889 -19.359 1.00 28.91 ?  405 ASN A CA  1 
ATOM   2982 C C   . ASN A 1 415 ? 46.444 -23.096 -20.440 1.00 31.18 ?  405 ASN A C   1 
ATOM   2983 O O   . ASN A 1 415 ? 46.908 -23.654 -21.432 1.00 28.95 ?  405 ASN A O   1 
ATOM   2984 C CB  . ASN A 1 415 ? 45.279 -25.269 -19.884 1.00 27.80 ?  405 ASN A CB  1 
ATOM   2985 C CG  . ASN A 1 415 ? 45.778 -26.406 -18.991 1.00 41.61 ?  405 ASN A CG  1 
ATOM   2986 O OD1 . ASN A 1 415 ? 46.864 -26.311 -18.433 1.00 37.34 ?  405 ASN A OD1 1 
ATOM   2987 N ND2 . ASN A 1 415 ? 45.004 -27.487 -18.877 1.00 33.34 ?  405 ASN A ND2 1 
ATOM   2988 N N   . VAL A 1 416 ? 46.542 -21.789 -20.257 1.00 26.85 ?  406 VAL A N   1 
ATOM   2989 C CA  . VAL A 1 416 ? 47.304 -20.904 -21.135 1.00 24.39 ?  406 VAL A CA  1 
ATOM   2990 C C   . VAL A 1 416 ? 48.730 -20.728 -20.619 1.00 27.14 ?  406 VAL A C   1 
ATOM   2991 O O   . VAL A 1 416 ? 48.980 -20.627 -19.407 1.00 23.78 ?  406 VAL A O   1 
ATOM   2992 C CB  . VAL A 1 416 ? 46.576 -19.556 -21.283 1.00 27.32 ?  406 VAL A CB  1 
ATOM   2993 C CG1 . VAL A 1 416 ? 47.504 -18.456 -21.905 1.00 27.39 ?  406 VAL A CG1 1 
ATOM   2994 C CG2 . VAL A 1 416 ? 45.356 -19.755 -22.167 1.00 24.99 ?  406 VAL A CG2 1 
ATOM   2995 N N   . ASN A 1 417 ? 49.688 -20.721 -21.541 1.00 22.83 ?  407 ASN A N   1 
ATOM   2996 C CA  . ASN A 1 417 ? 51.082 -20.459 -21.204 1.00 24.54 ?  407 ASN A CA  1 
ATOM   2997 C C   . ASN A 1 417 ? 51.455 -19.116 -21.798 1.00 30.44 ?  407 ASN A C   1 
ATOM   2998 O O   . ASN A 1 417 ? 51.392 -18.950 -23.020 1.00 29.15 ?  407 ASN A O   1 
ATOM   2999 C CB  . ASN A 1 417 ? 51.982 -21.544 -21.790 1.00 27.40 ?  407 ASN A CB  1 
ATOM   3000 C CG  . ASN A 1 417 ? 51.555 -22.921 -21.360 1.00 31.61 ?  407 ASN A CG  1 
ATOM   3001 O OD1 . ASN A 1 417 ? 51.394 -23.184 -20.170 1.00 32.75 ?  407 ASN A OD1 1 
ATOM   3002 N ND2 . ASN A 1 417 ? 51.269 -23.778 -22.335 1.00 34.25 ?  407 ASN A ND2 1 
ATOM   3003 N N   . LEU A 1 418 ? 51.838 -18.168 -20.953 1.00 27.65 ?  408 LEU A N   1 
ATOM   3004 C CA  . LEU A 1 418 ? 52.270 -16.854 -21.417 1.00 33.03 ?  408 LEU A CA  1 
ATOM   3005 C C   . LEU A 1 418 ? 53.787 -16.883 -21.426 1.00 30.17 ?  408 LEU A C   1 
ATOM   3006 O O   . LEU A 1 418 ? 54.416 -16.869 -20.359 1.00 32.48 ?  408 LEU A O   1 
ATOM   3007 C CB  . LEU A 1 418 ? 51.737 -15.743 -20.517 1.00 30.43 ?  408 LEU A CB  1 
ATOM   3008 C CG  . LEU A 1 418 ? 50.216 -15.669 -20.376 1.00 29.43 ?  408 LEU A CG  1 
ATOM   3009 C CD1 . LEU A 1 418 ? 49.864 -14.648 -19.328 1.00 32.16 ?  408 LEU A CD1 1 
ATOM   3010 C CD2 . LEU A 1 418 ? 49.531 -15.352 -21.696 1.00 27.37 ?  408 LEU A CD2 1 
ATOM   3011 N N   . VAL A 1 419 ? 54.380 -16.936 -22.620 1.00 33.53 ?  409 VAL A N   1 
ATOM   3012 C CA  . VAL A 1 419 ? 55.820 -17.137 -22.747 1.00 34.23 ?  409 VAL A CA  1 
ATOM   3013 C C   . VAL A 1 419 ? 56.481 -15.757 -22.743 1.00 39.03 ?  409 VAL A C   1 
ATOM   3014 O O   . VAL A 1 419 ? 56.496 -15.051 -23.756 1.00 33.86 ?  409 VAL A O   1 
ATOM   3015 C CB  . VAL A 1 419 ? 56.179 -17.938 -23.998 1.00 37.44 ?  409 VAL A CB  1 
ATOM   3016 C CG1 . VAL A 1 419 ? 57.688 -18.177 -24.044 1.00 36.90 ?  409 VAL A CG1 1 
ATOM   3017 C CG2 . VAL A 1 419 ? 55.396 -19.277 -24.038 1.00 33.67 ?  409 VAL A CG2 1 
ATOM   3018 N N   . ALA A 1 420 ? 57.063 -15.389 -21.605 1.00 30.97 ?  410 ALA A N   1 
ATOM   3019 C CA  . ALA A 1 420 ? 57.632 -14.061 -21.429 1.00 37.24 ?  410 ALA A CA  1 
ATOM   3020 C C   . ALA A 1 420 ? 58.957 -13.909 -22.186 1.00 37.13 ?  410 ALA A C   1 
ATOM   3021 O O   . ALA A 1 420 ? 59.656 -14.897 -22.449 1.00 30.51 ?  410 ALA A O   1 
ATOM   3022 C CB  . ALA A 1 420 ? 57.854 -13.774 -19.941 1.00 36.83 ?  410 ALA A CB  1 
ATOM   3023 N N   . PRO A 1 421 ? 59.330 -12.668 -22.545 1.00 33.53 ?  411 PRO A N   1 
ATOM   3024 C CA  . PRO A 1 421 ? 58.582 -11.416 -22.361 1.00 34.81 ?  411 PRO A CA  1 
ATOM   3025 C C   . PRO A 1 421 ? 57.399 -11.316 -23.320 1.00 37.43 ?  411 PRO A C   1 
ATOM   3026 O O   . PRO A 1 421 ? 57.497 -11.624 -24.505 1.00 37.43 ?  411 PRO A O   1 
ATOM   3027 C CB  . PRO A 1 421 ? 59.645 -10.344 -22.635 1.00 37.03 ?  411 PRO A CB  1 
ATOM   3028 C CG  . PRO A 1 421 ? 60.531 -10.995 -23.661 1.00 39.82 ?  411 PRO A CG  1 
ATOM   3029 C CD  . PRO A 1 421 ? 60.634 -12.425 -23.202 1.00 38.33 ?  411 PRO A CD  1 
ATOM   3030 N N   . VAL A 1 422 ? 56.243 -10.887 -22.825 1.00 32.25 ?  412 VAL A N   1 
ATOM   3031 C CA  . VAL A 1 422 ? 55.049 -10.823 -23.649 1.00 33.79 ?  412 VAL A CA  1 
ATOM   3032 C C   . VAL A 1 422 ? 54.089 -9.864  -22.971 1.00 39.18 ?  412 VAL A C   1 
ATOM   3033 O O   . VAL A 1 422 ? 54.097 -9.715  -21.740 1.00 34.49 ?  412 VAL A O   1 
ATOM   3034 C CB  . VAL A 1 422 ? 54.445 -12.241 -23.865 1.00 34.88 ?  412 VAL A CB  1 
ATOM   3035 C CG1 . VAL A 1 422 ? 53.903 -12.814 -22.558 1.00 34.64 ?  412 VAL A CG1 1 
ATOM   3036 C CG2 . VAL A 1 422 ? 53.368 -12.221 -24.918 1.00 34.18 ?  412 VAL A CG2 1 
ATOM   3037 N N   . THR A 1 423 ? 53.287 -9.175  -23.781 1.00 35.27 ?  413 THR A N   1 
ATOM   3038 C CA  . THR A 1 423 ? 52.319 -8.206  -23.290 1.00 29.29 ?  413 THR A CA  1 
ATOM   3039 C C   . THR A 1 423 ? 50.944 -8.530  -23.842 1.00 35.53 ?  413 THR A C   1 
ATOM   3040 O O   . THR A 1 423 ? 50.769 -8.638  -25.062 1.00 34.39 ?  413 THR A O   1 
ATOM   3041 C CB  . THR A 1 423 ? 52.721 -6.767  -23.665 1.00 36.47 ?  413 THR A CB  1 
ATOM   3042 O OG1 . THR A 1 423 ? 53.933 -6.423  -22.980 1.00 36.53 ?  413 THR A OG1 1 
ATOM   3043 C CG2 . THR A 1 423 ? 51.633 -5.782  -23.280 1.00 34.27 ?  413 THR A CG2 1 
ATOM   3044 N N   . ILE A 1 424 ? 49.976 -8.687  -22.939 1.00 30.67 ?  414 ILE A N   1 
ATOM   3045 C CA  . ILE A 1 424 ? 48.577 -8.904  -23.279 1.00 30.92 ?  414 ILE A CA  1 
ATOM   3046 C C   . ILE A 1 424 ? 47.843 -7.605  -22.976 1.00 34.47 ?  414 ILE A C   1 
ATOM   3047 O O   . ILE A 1 424 ? 47.959 -7.069  -21.865 1.00 28.53 ?  414 ILE A O   1 
ATOM   3048 C CB  . ILE A 1 424 ? 47.968 -10.071 -22.473 1.00 30.25 ?  414 ILE A CB  1 
ATOM   3049 C CG1 . ILE A 1 424 ? 48.807 -11.350 -22.578 1.00 34.68 ?  414 ILE A CG1 1 
ATOM   3050 C CG2 . ILE A 1 424 ? 46.550 -10.363 -22.957 1.00 30.60 ?  414 ILE A CG2 1 
ATOM   3051 C CD1 . ILE A 1 424 ? 48.887 -11.962 -23.973 1.00 33.26 ?  414 ILE A CD1 1 
ATOM   3052 N N   . GLY A 1 425 ? 47.094 -7.097  -23.950 1.00 28.64 ?  415 GLY A N   1 
ATOM   3053 C CA  . GLY A 1 425 ? 46.424 -5.817  -23.801 1.00 32.65 ?  415 GLY A CA  1 
ATOM   3054 C C   . GLY A 1 425 ? 45.198 -5.852  -22.892 1.00 37.11 ?  415 GLY A C   1 
ATOM   3055 O O   . GLY A 1 425 ? 44.913 -6.822  -22.186 1.00 35.70 ?  415 GLY A O   1 
ATOM   3056 N N   . ASP A 1 426 ? 44.470 -4.734  -22.909 1.00 29.54 ?  416 ASP A N   1 
ATOM   3057 C CA  . ASP A 1 426 ? 43.215 -4.592  -22.172 1.00 33.72 ?  416 ASP A CA  1 
ATOM   3058 C C   . ASP A 1 426 ? 42.063 -5.194  -22.968 1.00 30.80 ?  416 ASP A C   1 
ATOM   3059 O O   . ASP A 1 426 ? 42.091 -5.225  -24.202 1.00 33.48 ?  416 ASP A O   1 
ATOM   3060 C CB  . ASP A 1 426 ? 42.881 -3.119  -21.906 1.00 34.87 ?  416 ASP A CB  1 
ATOM   3061 C CG  . ASP A 1 426 ? 43.965 -2.372  -21.130 1.00 45.48 ?  416 ASP A CG  1 
ATOM   3062 O OD1 . ASP A 1 426 ? 44.752 -2.986  -20.363 1.00 33.35 ?  416 ASP A OD1 1 
ATOM   3063 O OD2 . ASP A 1 426 ? 44.011 -1.129  -21.286 1.00 43.80 -1 416 ASP A OD2 1 
ATOM   3064 N N   . ASP A 1 427 ? 41.032 -5.644  -22.247 1.00 27.39 ?  417 ASP A N   1 
ATOM   3065 C CA  . ASP A 1 427 ? 39.836 -6.247  -22.846 1.00 34.46 ?  417 ASP A CA  1 
ATOM   3066 C C   . ASP A 1 427 ? 40.185 -7.302  -23.889 1.00 34.14 ?  417 ASP A C   1 
ATOM   3067 O O   . ASP A 1 427 ? 39.611 -7.345  -24.978 1.00 35.09 ?  417 ASP A O   1 
ATOM   3068 C CB  . ASP A 1 427 ? 38.887 -5.185  -23.437 1.00 38.88 ?  417 ASP A CB  1 
ATOM   3069 C CG  . ASP A 1 427 ? 38.679 -3.977  -22.511 1.00 45.13 ?  417 ASP A CG  1 
ATOM   3070 O OD1 . ASP A 1 427 ? 37.764 -4.081  -21.653 1.00 48.72 ?  417 ASP A OD1 1 
ATOM   3071 O OD2 . ASP A 1 427 ? 39.348 -2.925  -22.665 1.00 43.15 ?  417 ASP A OD2 1 
ATOM   3072 N N   . VAL A 1 428 ? 41.124 -8.162  -23.539 1.00 29.12 ?  418 VAL A N   1 
ATOM   3073 C CA  . VAL A 1 428 ? 41.588 -9.258  -24.385 1.00 30.23 ?  418 VAL A CA  1 
ATOM   3074 C C   . VAL A 1 428 ? 41.008 -10.572 -23.885 1.00 30.68 ?  418 VAL A C   1 
ATOM   3075 O O   . VAL A 1 428 ? 40.878 -10.777 -22.673 1.00 26.04 ?  418 VAL A O   1 
ATOM   3076 C CB  . VAL A 1 428 ? 43.125 -9.313  -24.385 1.00 31.69 ?  418 VAL A CB  1 
ATOM   3077 C CG1 . VAL A 1 428 ? 43.640 -10.616 -25.029 1.00 29.78 ?  418 VAL A CG1 1 
ATOM   3078 C CG2 . VAL A 1 428 ? 43.681 -8.100  -25.099 1.00 33.55 ?  418 VAL A CG2 1 
ATOM   3079 N N   . LEU A 1 429 ? 40.670 -11.471 -24.816 1.00 29.98 ?  419 LEU A N   1 
ATOM   3080 C CA  . LEU A 1 429 ? 40.349 -12.856 -24.496 1.00 28.42 ?  419 LEU A CA  1 
ATOM   3081 C C   . LEU A 1 429 ? 41.438 -13.746 -25.085 1.00 36.59 ?  419 LEU A C   1 
ATOM   3082 O O   . LEU A 1 429 ? 41.748 -13.646 -26.280 1.00 33.91 ?  419 LEU A O   1 
ATOM   3083 C CB  . LEU A 1 429 ? 38.985 -13.264 -25.059 1.00 30.06 ?  419 LEU A CB  1 
ATOM   3084 C CG  . LEU A 1 429 ? 38.515 -14.658 -24.595 1.00 40.58 ?  419 LEU A CG  1 
ATOM   3085 C CD1 . LEU A 1 429 ? 37.051 -14.620 -24.258 1.00 46.47 ?  419 LEU A CD1 1 
ATOM   3086 C CD2 . LEU A 1 429 ? 38.804 -15.760 -25.557 1.00 43.61 ?  419 LEU A CD2 1 
ATOM   3087 N N   . VAL A 1 430 ? 42.038 -14.593 -24.254 1.00 28.82 ?  420 VAL A N   1 
ATOM   3088 C CA  . VAL A 1 430 ? 42.973 -15.618 -24.717 1.00 29.31 ?  420 VAL A CA  1 
ATOM   3089 C C   . VAL A 1 430 ? 42.279 -16.969 -24.545 1.00 37.89 ?  420 VAL A C   1 
ATOM   3090 O O   . VAL A 1 430 ? 41.919 -17.342 -23.418 1.00 30.49 ?  420 VAL A O   1 
ATOM   3091 C CB  . VAL A 1 430 ? 44.296 -15.578 -23.943 1.00 28.18 ?  420 VAL A CB  1 
ATOM   3092 C CG1 . VAL A 1 430 ? 45.263 -16.676 -24.459 1.00 32.61 ?  420 VAL A CG1 1 
ATOM   3093 C CG2 . VAL A 1 430 ? 44.940 -14.188 -24.022 1.00 30.24 ?  420 VAL A CG2 1 
ATOM   3094 N N   . ALA A 1 431 ? 42.106 -17.706 -25.652 1.00 31.15 ?  421 ALA A N   1 
ATOM   3095 C CA  . ALA A 1 431 ? 41.357 -18.959 -25.640 1.00 34.12 ?  421 ALA A CA  1 
ATOM   3096 C C   . ALA A 1 431 ? 42.070 -20.022 -24.817 1.00 26.87 ?  421 ALA A C   1 
ATOM   3097 O O   . ALA A 1 431 ? 43.297 -20.048 -24.726 1.00 30.65 ?  421 ALA A O   1 
ATOM   3098 C CB  . ALA A 1 431 ? 41.150 -19.484 -27.067 1.00 36.42 ?  421 ALA A CB  1 
ATOM   3099 N N   . ALA A 1 432 ? 41.278 -20.901 -24.207 1.00 34.67 ?  422 ALA A N   1 
ATOM   3100 C CA  . ALA A 1 432 ? 41.825 -21.954 -23.354 1.00 29.83 ?  422 ALA A CA  1 
ATOM   3101 C C   . ALA A 1 432 ? 42.781 -22.840 -24.140 1.00 35.34 ?  422 ALA A C   1 
ATOM   3102 O O   . ALA A 1 432 ? 42.536 -23.165 -25.306 1.00 31.28 ?  422 ALA A O   1 
ATOM   3103 C CB  . ALA A 1 432 ? 40.681 -22.795 -22.755 1.00 26.50 ?  422 ALA A CB  1 
ATOM   3104 N N   . GLY A 1 433 ? 43.897 -23.209 -23.505 1.00 28.29 ?  423 GLY A N   1 
ATOM   3105 C CA  . GLY A 1 433 ? 44.843 -24.122 -24.114 1.00 32.49 ?  423 GLY A CA  1 
ATOM   3106 C C   . GLY A 1 433 ? 45.869 -23.477 -25.019 1.00 33.61 ?  423 GLY A C   1 
ATOM   3107 O O   . GLY A 1 433 ? 46.542 -24.189 -25.761 1.00 34.03 ?  423 GLY A O   1 
ATOM   3108 N N   . SER A 1 434 ? 46.011 -22.157 -24.980 1.00 28.45 ?  424 SER A N   1 
ATOM   3109 C CA  . SER A 1 434 ? 46.879 -21.449 -25.904 1.00 31.11 ?  424 SER A CA  1 
ATOM   3110 C C   . SER A 1 434 ? 48.263 -21.247 -25.313 1.00 32.91 ?  424 SER A C   1 
ATOM   3111 O O   . SER A 1 434 ? 48.410 -20.871 -24.144 1.00 30.09 ?  424 SER A O   1 
ATOM   3112 C CB  . SER A 1 434 ? 46.267 -20.104 -26.281 1.00 28.67 ?  424 SER A CB  1 
ATOM   3113 O OG  . SER A 1 434 ? 45.024 -20.311 -26.929 1.00 31.63 ?  424 SER A OG  1 
ATOM   3114 N N   . THR A 1 435 ? 49.283 -21.503 -26.117 1.00 32.84 ?  425 THR A N   1 
ATOM   3115 C CA  . THR A 1 435 ? 50.627 -21.054 -25.788 1.00 37.43 ?  425 THR A CA  1 
ATOM   3116 C C   . THR A 1 435 ? 50.847 -19.742 -26.523 1.00 37.32 ?  425 THR A C   1 
ATOM   3117 O O   . THR A 1 435 ? 50.875 -19.710 -27.760 1.00 32.37 ?  425 THR A O   1 
ATOM   3118 C CB  . THR A 1 435 ? 51.670 -22.109 -26.151 1.00 31.86 ?  425 THR A CB  1 
ATOM   3119 O OG1 . THR A 1 435 ? 51.471 -23.265 -25.325 1.00 34.80 ?  425 THR A OG1 1 
ATOM   3120 C CG2 . THR A 1 435 ? 53.063 -21.561 -25.941 1.00 31.62 ?  425 THR A CG2 1 
ATOM   3121 N N   . ILE A 1 436 ? 50.996 -18.660 -25.765 1.00 27.42 ?  426 ILE A N   1 
ATOM   3122 C CA  . ILE A 1 436 ? 51.075 -17.312 -26.325 1.00 34.19 ?  426 ILE A CA  1 
ATOM   3123 C C   . ILE A 1 436 ? 52.542 -16.890 -26.351 1.00 32.66 ?  426 ILE A C   1 
ATOM   3124 O O   . ILE A 1 436 ? 53.197 -16.782 -25.303 1.00 35.73 ?  426 ILE A O   1 
ATOM   3125 C CB  . ILE A 1 436 ? 50.215 -16.317 -25.523 1.00 33.43 ?  426 ILE A CB  1 
ATOM   3126 C CG1 . ILE A 1 436 ? 48.728 -16.651 -25.630 1.00 34.89 ?  426 ILE A CG1 1 
ATOM   3127 C CG2 . ILE A 1 436 ? 50.389 -14.900 -26.048 1.00 34.22 ?  426 ILE A CG2 1 
ATOM   3128 C CD1 . ILE A 1 436 ? 48.259 -17.111 -27.016 1.00 40.10 ?  426 ILE A CD1 1 
ATOM   3129 N N   . THR A 1 437 ? 53.072 -16.695 -27.559 1.00 30.17 ?  427 THR A N   1 
ATOM   3130 C CA  . THR A 1 437 ? 54.438 -16.227 -27.757 1.00 37.45 ?  427 THR A CA  1 
ATOM   3131 C C   . THR A 1 437 ? 54.523 -14.764 -28.191 1.00 39.69 ?  427 THR A C   1 
ATOM   3132 O O   . THR A 1 437 ? 55.570 -14.136 -27.991 1.00 37.85 ?  427 THR A O   1 
ATOM   3133 C CB  . THR A 1 437 ? 55.148 -17.092 -28.815 1.00 34.48 ?  427 THR A CB  1 
ATOM   3134 O OG1 . THR A 1 437 ? 54.361 -17.107 -30.012 1.00 34.43 ?  427 THR A OG1 1 
ATOM   3135 C CG2 . THR A 1 437 ? 55.314 -18.530 -28.331 1.00 37.33 ?  427 THR A CG2 1 
ATOM   3136 N N   . ASP A 1 438 ? 53.455 -14.215 -28.770 1.00 37.14 ?  428 ASP A N   1 
ATOM   3137 C CA  . ASP A 1 438 ? 53.439 -12.890 -29.384 1.00 43.05 ?  428 ASP A CA  1 
ATOM   3138 C C   . ASP A 1 438 ? 52.573 -11.932 -28.579 1.00 38.13 ?  428 ASP A C   1 
ATOM   3139 O O   . ASP A 1 438 ? 51.553 -12.328 -28.013 1.00 38.12 ?  428 ASP A O   1 
ATOM   3140 C CB  . ASP A 1 438 ? 52.876 -12.955 -30.811 1.00 39.04 ?  428 ASP A CB  1 
ATOM   3141 C CG  . ASP A 1 438 ? 53.551 -14.030 -31.669 1.00 52.07 ?  428 ASP A CG  1 
ATOM   3142 O OD1 . ASP A 1 438 ? 54.528 -14.640 -31.196 1.00 50.29 ?  428 ASP A OD1 1 
ATOM   3143 O OD2 . ASP A 1 438 ? 53.061 -14.304 -32.797 1.00 58.32 ?  428 ASP A OD2 1 
ATOM   3144 N N   . ASP A 1 439 ? 52.956 -10.654 -28.584 1.00 37.94 ?  429 ASP A N   1 
ATOM   3145 C CA  . ASP A 1 439 ? 52.144 -9.616  -27.955 1.00 36.49 ?  429 ASP A CA  1 
ATOM   3146 C C   . ASP A 1 439 ? 50.726 -9.588  -28.533 1.00 41.32 ?  429 ASP A C   1 
ATOM   3147 O O   . ASP A 1 439 ? 50.510 -9.836  -29.723 1.00 38.41 ?  429 ASP A O   1 
ATOM   3148 C CB  . ASP A 1 439 ? 52.798 -8.257  -28.162 1.00 36.61 ?  429 ASP A CB  1 
ATOM   3149 C CG  . ASP A 1 439 ? 53.987 -8.048  -27.272 1.00 48.49 ?  429 ASP A CG  1 
ATOM   3150 O OD1 . ASP A 1 439 ? 54.332 -8.965  -26.485 1.00 42.15 ?  429 ASP A OD1 1 
ATOM   3151 O OD2 . ASP A 1 439 ? 54.587 -6.963  -27.375 1.00 52.91 -1 429 ASP A OD2 1 
ATOM   3152 N N   . VAL A 1 440 ? 49.749 -9.269  -27.688 1.00 33.85 ?  430 VAL A N   1 
ATOM   3153 C CA  . VAL A 1 440 ? 48.345 -9.245  -28.081 1.00 35.46 ?  430 VAL A CA  1 
ATOM   3154 C C   . VAL A 1 440 ? 47.783 -7.851  -27.818 1.00 35.77 ?  430 VAL A C   1 
ATOM   3155 O O   . VAL A 1 440 ? 47.770 -7.395  -26.668 1.00 30.97 ?  430 VAL A O   1 
ATOM   3156 C CB  . VAL A 1 440 ? 47.513 -10.310 -27.342 1.00 32.83 ?  430 VAL A CB  1 
ATOM   3157 C CG1 . VAL A 1 440 ? 46.075 -10.237 -27.802 1.00 32.51 ?  430 VAL A CG1 1 
ATOM   3158 C CG2 . VAL A 1 440 ? 48.105 -11.729 -27.585 1.00 36.41 ?  430 VAL A CG2 1 
ATOM   3159 N N   . PRO A 1 441 ? 47.297 -7.142  -28.841 1.00 33.47 ?  431 PRO A N   1 
ATOM   3160 C CA  . PRO A 1 441 ? 46.834 -5.758  -28.640 1.00 39.51 ?  431 PRO A CA  1 
ATOM   3161 C C   . PRO A 1 441 ? 45.505 -5.713  -27.898 1.00 37.61 ?  431 PRO A C   1 
ATOM   3162 O O   . PRO A 1 441 ? 44.833 -6.726  -27.704 1.00 36.74 ?  431 PRO A O   1 
ATOM   3163 C CB  . PRO A 1 441 ? 46.680 -5.198  -30.065 1.00 40.49 ?  431 PRO A CB  1 
ATOM   3164 C CG  . PRO A 1 441 ? 46.793 -6.405  -30.997 1.00 44.79 ?  431 PRO A CG  1 
ATOM   3165 C CD  . PRO A 1 441 ? 47.570 -7.452  -30.261 1.00 40.13 ?  431 PRO A CD  1 
ATOM   3166 N N   . ASN A 1 442 ? 45.122 -4.499  -27.492 1.00 33.55 ?  432 ASN A N   1 
ATOM   3167 C CA  . ASN A 1 442 ? 43.834 -4.284  -26.842 1.00 40.53 ?  432 ASN A CA  1 
ATOM   3168 C C   . ASN A 1 442 ? 42.693 -4.814  -27.704 1.00 35.57 ?  432 ASN A C   1 
ATOM   3169 O O   . ASN A 1 442 ? 42.770 -4.816  -28.934 1.00 41.20 ?  432 ASN A O   1 
ATOM   3170 C CB  . ASN A 1 442 ? 43.591 -2.788  -26.576 1.00 41.72 ?  432 ASN A CB  1 
ATOM   3171 C CG  . ASN A 1 442 ? 44.548 -2.196  -25.564 1.00 44.93 ?  432 ASN A CG  1 
ATOM   3172 O OD1 . ASN A 1 442 ? 45.191 -2.917  -24.786 1.00 38.11 ?  432 ASN A OD1 1 
ATOM   3173 N ND2 . ASN A 1 442 ? 44.641 -0.858  -25.554 1.00 43.49 ?  432 ASN A ND2 1 
ATOM   3174 N N   . ASP A 1 443 ? 41.620 -5.246  -27.032 1.00 33.87 ?  433 ASP A N   1 
ATOM   3175 C CA  . ASP A 1 443 ? 40.353 -5.676  -27.644 1.00 40.09 ?  433 ASP A CA  1 
ATOM   3176 C C   . ASP A 1 443 ? 40.537 -6.763  -28.698 1.00 47.74 ?  433 ASP A C   1 
ATOM   3177 O O   . ASP A 1 443 ? 39.968 -6.704  -29.791 1.00 43.50 ?  433 ASP A O   1 
ATOM   3178 C CB  . ASP A 1 443 ? 39.578 -4.489  -28.225 1.00 57.41 ?  433 ASP A CB  1 
ATOM   3179 C CG  . ASP A 1 443 ? 39.685 -3.243  -27.367 1.00 49.33 ?  433 ASP A CG  1 
ATOM   3180 O OD1 . ASP A 1 443 ? 39.007 -3.195  -26.316 1.00 57.39 ?  433 ASP A OD1 1 
ATOM   3181 O OD2 . ASP A 1 443 ? 40.440 -2.320  -27.728 1.00 56.66 -1 433 ASP A OD2 1 
ATOM   3182 N N   . SER A 1 444 ? 41.280 -7.802  -28.334 1.00 36.35 ?  434 SER A N   1 
ATOM   3183 C CA  . SER A 1 444 ? 41.642 -8.850  -29.271 1.00 35.76 ?  434 SER A CA  1 
ATOM   3184 C C   . SER A 1 444 ? 41.260 -10.222 -28.734 1.00 35.96 ?  434 SER A C   1 
ATOM   3185 O O   . SER A 1 444 ? 41.119 -10.437 -27.527 1.00 32.94 ?  434 SER A O   1 
ATOM   3186 C CB  . SER A 1 444 ? 43.142 -8.827  -29.575 1.00 37.74 ?  434 SER A CB  1 
ATOM   3187 O OG  . SER A 1 444 ? 43.504 -7.592  -30.165 1.00 44.36 ?  434 SER A OG  1 
ATOM   3188 N N   . LEU A 1 445 ? 41.088 -11.152 -29.668 1.00 34.50 ?  435 LEU A N   1 
ATOM   3189 C CA  . LEU A 1 445 ? 41.023 -12.579 -29.389 1.00 35.61 ?  435 LEU A CA  1 
ATOM   3190 C C   . LEU A 1 445 ? 42.325 -13.226 -29.834 1.00 42.69 ?  435 LEU A C   1 
ATOM   3191 O O   . LEU A 1 445 ? 42.780 -12.989 -30.959 1.00 42.22 ?  435 LEU A O   1 
ATOM   3192 C CB  . LEU A 1 445 ? 39.833 -13.211 -30.109 1.00 40.45 ?  435 LEU A CB  1 
ATOM   3193 C CG  . LEU A 1 445 ? 39.804 -14.736 -30.155 1.00 48.62 ?  435 LEU A CG  1 
ATOM   3194 C CD1 . LEU A 1 445 ? 39.658 -15.296 -28.767 1.00 45.89 ?  435 LEU A CD1 1 
ATOM   3195 C CD2 . LEU A 1 445 ? 38.655 -15.200 -31.030 1.00 49.60 ?  435 LEU A CD2 1 
ATOM   3196 N N   . ALA A 1 446 ? 42.936 -14.027 -28.955 1.00 33.99 ?  436 ALA A N   1 
ATOM   3197 C CA  . ALA A 1 446 ? 44.162 -14.744 -29.294 1.00 37.86 ?  436 ALA A CA  1 
ATOM   3198 C C   . ALA A 1 446 ? 43.952 -16.225 -29.027 1.00 40.59 ?  436 ALA A C   1 
ATOM   3199 O O   . ALA A 1 446 ? 43.412 -16.592 -27.975 1.00 36.16 ?  436 ALA A O   1 
ATOM   3200 C CB  . ALA A 1 446 ? 45.374 -14.212 -28.507 1.00 36.61 ?  436 ALA A CB  1 
ATOM   3201 N N   . VAL A 1 447 ? 44.371 -17.072 -29.972 1.00 34.40 ?  437 VAL A N   1 
ATOM   3202 C CA  . VAL A 1 447 ? 44.153 -18.514 -29.865 1.00 34.64 ?  437 VAL A CA  1 
ATOM   3203 C C   . VAL A 1 447 ? 45.340 -19.258 -30.483 1.00 37.67 ?  437 VAL A C   1 
ATOM   3204 O O   . VAL A 1 447 ? 45.923 -18.823 -31.479 1.00 36.80 ?  437 VAL A O   1 
ATOM   3205 C CB  . VAL A 1 447 ? 42.803 -18.907 -30.505 1.00 38.85 ?  437 VAL A CB  1 
ATOM   3206 C CG1 . VAL A 1 447 ? 42.846 -18.667 -32.001 1.00 41.50 ?  437 VAL A CG1 1 
ATOM   3207 C CG2 . VAL A 1 447 ? 42.454 -20.375 -30.191 1.00 34.08 ?  437 VAL A CG2 1 
ATOM   3208 N N   . ALA A 1 448 ? 45.733 -20.375 -29.848 1.00 34.95 ?  438 ALA A N   1 
ATOM   3209 C CA  . ALA A 1 448 ? 46.891 -21.149 -30.321 1.00 31.10 ?  438 ALA A CA  1 
ATOM   3210 C C   . ALA A 1 448 ? 46.672 -22.590 -29.872 1.00 39.52 ?  438 ALA A C   1 
ATOM   3211 O O   . ALA A 1 448 ? 47.296 -23.078 -28.928 1.00 37.66 ?  438 ALA A O   1 
ATOM   3212 C CB  . ALA A 1 448 ? 48.225 -20.616 -29.794 1.00 36.13 ?  438 ALA A CB  1 
ATOM   3213 N N   . ARG A 1 449 ? 45.794 -23.288 -30.580 1.00 36.50 ?  439 ARG A N   1 
ATOM   3214 C CA  . ARG A 1 449 ? 45.481 -24.652 -30.190 1.00 38.23 ?  439 ARG A CA  1 
ATOM   3215 C C   . ARG A 1 449 ? 44.940 -25.387 -31.404 1.00 39.18 ?  439 ARG A C   1 
ATOM   3216 O O   . ARG A 1 449 ? 44.445 -24.779 -32.356 1.00 38.15 ?  439 ARG A O   1 
ATOM   3217 C CB  . ARG A 1 449 ? 44.479 -24.690 -29.034 1.00 34.20 ?  439 ARG A CB  1 
ATOM   3218 C CG  . ARG A 1 449 ? 43.022 -24.527 -29.467 1.00 44.26 ?  439 ARG A CG  1 
ATOM   3219 C CD  . ARG A 1 449 ? 42.210 -23.801 -28.424 1.00 44.72 ?  439 ARG A CD  1 
ATOM   3220 N NE  . ARG A 1 449 ? 40.792 -23.767 -28.773 1.00 39.51 ?  439 ARG A NE  1 
ATOM   3221 C CZ  . ARG A 1 449 ? 39.837 -23.269 -27.999 1.00 39.51 ?  439 ARG A CZ  1 
ATOM   3222 N NH1 . ARG A 1 449 ? 40.105 -22.782 -26.799 1.00 31.03 ?  439 ARG A NH1 1 
ATOM   3223 N NH2 . ARG A 1 449 ? 38.581 -23.232 -28.453 1.00 40.52 ?  439 ARG A NH2 1 
ATOM   3224 N N   . ALA A 1 450 ? 45.062 -26.708 -31.362 1.00 36.90 ?  440 ALA A N   1 
ATOM   3225 C CA  . ALA A 1 450 ? 44.541 -27.538 -32.435 1.00 43.23 ?  440 ALA A CA  1 
ATOM   3226 C C   . ALA A 1 450 ? 43.022 -27.617 -32.346 1.00 43.25 ?  440 ALA A C   1 
ATOM   3227 O O   . ALA A 1 450 ? 42.432 -27.500 -31.265 1.00 42.70 ?  440 ALA A O   1 
ATOM   3228 C CB  . ALA A 1 450 ? 45.152 -28.940 -32.364 1.00 40.21 ?  440 ALA A CB  1 
ATOM   3229 N N   . ARG A 1 451 ? 42.387 -27.780 -33.503 1.00 38.85 ?  441 ARG A N   1 
ATOM   3230 C CA  . ARG A 1 451 ? 40.961 -28.043 -33.528 1.00 45.99 ?  441 ARG A CA  1 
ATOM   3231 C C   . ARG A 1 451 ? 40.704 -29.519 -33.236 1.00 41.37 ?  441 ARG A C   1 
ATOM   3232 O O   . ARG A 1 451 ? 41.602 -30.369 -33.330 1.00 39.26 ?  441 ARG A O   1 
ATOM   3233 C CB  . ARG A 1 451 ? 40.357 -27.621 -34.871 1.00 45.79 ?  441 ARG A CB  1 
ATOM   3234 C CG  . ARG A 1 451 ? 40.252 -26.102 -34.995 1.00 49.68 ?  441 ARG A CG  1 
ATOM   3235 C CD  . ARG A 1 451 ? 39.228 -25.651 -36.005 1.00 55.31 ?  441 ARG A CD  1 
ATOM   3236 N NE  . ARG A 1 451 ? 39.488 -24.285 -36.440 1.00 54.78 ?  441 ARG A NE  1 
ATOM   3237 C CZ  . ARG A 1 451 ? 38.664 -23.271 -36.215 1.00 53.15 ?  441 ARG A CZ  1 
ATOM   3238 N NH1 . ARG A 1 451 ? 37.536 -23.437 -35.544 1.00 59.35 ?  441 ARG A NH1 1 
ATOM   3239 N NH2 . ARG A 1 451 ? 38.991 -22.057 -36.653 1.00 55.32 ?  441 ARG A NH2 1 
ATOM   3240 N N   . GLN A 1 452 ? 39.465 -29.815 -32.855 1.00 37.29 ?  442 GLN A N   1 
ATOM   3241 C CA  . GLN A 1 452 ? 39.101 -31.133 -32.341 1.00 36.74 ?  442 GLN A CA  1 
ATOM   3242 C C   . GLN A 1 452 ? 38.797 -32.126 -33.461 1.00 42.10 ?  442 GLN A C   1 
ATOM   3243 O O   . GLN A 1 452 ? 38.067 -31.808 -34.406 1.00 45.34 ?  442 GLN A O   1 
ATOM   3244 C CB  . GLN A 1 452 ? 37.896 -31.011 -31.408 1.00 33.83 ?  442 GLN A CB  1 
ATOM   3245 C CG  . GLN A 1 452 ? 37.394 -32.320 -30.836 1.00 35.48 ?  442 GLN A CG  1 
ATOM   3246 C CD  . GLN A 1 452 ? 36.206 -32.109 -29.902 1.00 36.39 ?  442 GLN A CD  1 
ATOM   3247 O OE1 . GLN A 1 452 ? 36.060 -31.040 -29.314 1.00 35.37 ?  442 GLN A OE1 1 
ATOM   3248 N NE2 . GLN A 1 452 ? 35.348 -33.127 -29.774 1.00 32.80 ?  442 GLN A NE2 1 
ATOM   3249 N N   . THR A 1 453 ? 39.360 -33.331 -33.339 1.00 39.07 ?  443 THR A N   1 
ATOM   3250 C CA  . THR A 1 453 ? 39.005 -34.489 -34.153 1.00 42.77 ?  443 THR A CA  1 
ATOM   3251 C C   . THR A 1 453 ? 38.268 -35.512 -33.297 1.00 41.49 ?  443 THR A C   1 
ATOM   3252 O O   . THR A 1 453 ? 38.780 -35.942 -32.256 1.00 46.12 ?  443 THR A O   1 
ATOM   3253 C CB  . THR A 1 453 ? 40.249 -35.143 -34.764 1.00 41.51 ?  443 THR A CB  1 
ATOM   3254 O OG1 . THR A 1 453 ? 40.870 -34.237 -35.686 1.00 43.82 ?  443 THR A OG1 1 
ATOM   3255 C CG2 . THR A 1 453 ? 39.878 -36.433 -35.463 1.00 38.93 ?  443 THR A CG2 1 
ATOM   3256 N N   . THR A 1 454 ? 37.086 -35.920 -33.748 1.00 40.01 ?  444 THR A N   1 
ATOM   3257 C CA  . THR A 1 454 ? 36.262 -36.905 -33.053 1.00 39.00 ?  444 THR A CA  1 
ATOM   3258 C C   . THR A 1 454 ? 36.155 -38.160 -33.913 1.00 51.26 ?  444 THR A C   1 
ATOM   3259 O O   . THR A 1 454 ? 35.634 -38.105 -35.037 1.00 43.25 ?  444 THR A O   1 
ATOM   3260 C CB  . THR A 1 454 ? 34.881 -36.325 -32.734 1.00 42.23 ?  444 THR A CB  1 
ATOM   3261 O OG1 . THR A 1 454 ? 35.041 -35.177 -31.896 1.00 40.63 ?  444 THR A OG1 1 
ATOM   3262 C CG2 . THR A 1 454 ? 33.988 -37.347 -32.020 1.00 39.60 ?  444 THR A CG2 1 
ATOM   3263 N N   . LYS A 1 455 ? 36.664 -39.281 -33.383 1.00 39.41 ?  445 LYS A N   1 
ATOM   3264 C CA  . LYS A 1 455 ? 36.669 -40.573 -34.074 1.00 51.51 ?  445 LYS A CA  1 
ATOM   3265 C C   . LYS A 1 455 ? 35.594 -41.460 -33.446 1.00 46.11 ?  445 LYS A C   1 
ATOM   3266 O O   . LYS A 1 455 ? 35.855 -42.282 -32.566 1.00 43.94 ?  445 LYS A O   1 
ATOM   3267 C CB  . LYS A 1 455 ? 38.054 -41.224 -34.003 1.00 42.73 ?  445 LYS A CB  1 
ATOM   3268 C CG  . LYS A 1 455 ? 39.123 -40.462 -34.759 1.00 50.04 ?  445 LYS A CG  1 
ATOM   3269 C CD  . LYS A 1 455 ? 40.347 -41.323 -35.012 1.00 56.47 ?  445 LYS A CD  1 
ATOM   3270 C CE  . LYS A 1 455 ? 41.601 -40.481 -35.038 1.00 60.83 ?  445 LYS A CE  1 
ATOM   3271 N NZ  . LYS A 1 455 ? 42.111 -40.303 -36.429 1.00 67.60 ?  445 LYS A NZ  1 
ATOM   3272 N N   . GLU A 1 456 ? 34.360 -41.270 -33.914 1.00 41.98 ?  446 GLU A N   1 
ATOM   3273 C CA  . GLU A 1 456 ? 33.226 -42.033 -33.409 1.00 61.22 ?  446 GLU A CA  1 
ATOM   3274 C C   . GLU A 1 456 ? 33.391 -43.524 -33.682 1.00 54.51 ?  446 GLU A C   1 
ATOM   3275 O O   . GLU A 1 456 ? 33.785 -43.934 -34.775 1.00 59.05 ?  446 GLU A O   1 
ATOM   3276 C CB  . GLU A 1 456 ? 31.926 -41.531 -34.039 1.00 54.15 ?  446 GLU A CB  1 
ATOM   3277 C CG  . GLU A 1 456 ? 30.706 -42.325 -33.581 1.00 66.11 ?  446 GLU A CG  1 
ATOM   3278 C CD  . GLU A 1 456 ? 29.441 -41.500 -33.527 1.00 70.37 ?  446 GLU A CD  1 
ATOM   3279 O OE1 . GLU A 1 456 ? 29.421 -40.404 -34.136 1.00 67.51 ?  446 GLU A OE1 1 
ATOM   3280 O OE2 . GLU A 1 456 ? 28.463 -41.965 -32.897 1.00 65.29 ?  446 GLU A OE2 1 
ATOM   3281 N N   . GLY A 1 457 ? 33.076 -44.340 -32.676 1.00 55.84 ?  447 GLY A N   1 
ATOM   3282 C CA  . GLY A 1 457 ? 33.192 -45.773 -32.828 1.00 46.53 ?  447 GLY A CA  1 
ATOM   3283 C C   . GLY A 1 457 ? 34.601 -46.278 -33.011 1.00 58.92 ?  447 GLY A C   1 
ATOM   3284 O O   . GLY A 1 457 ? 34.784 -47.473 -33.270 1.00 54.49 ?  447 GLY A O   1 
ATOM   3285 N N   . TYR A 1 458 ? 35.610 -45.404 -32.898 1.00 53.26 ?  448 TYR A N   1 
ATOM   3286 C CA  . TYR A 1 458 ? 36.993 -45.870 -32.902 1.00 52.38 ?  448 TYR A CA  1 
ATOM   3287 C C   . TYR A 1 458 ? 37.191 -46.948 -31.847 1.00 52.09 ?  448 TYR A C   1 
ATOM   3288 O O   . TYR A 1 458 ? 37.993 -47.872 -32.030 1.00 58.58 ?  448 TYR A O   1 
ATOM   3289 C CB  . TYR A 1 458 ? 37.940 -44.685 -32.660 1.00 52.26 ?  448 TYR A CB  1 
ATOM   3290 C CG  . TYR A 1 458 ? 39.392 -44.980 -32.945 1.00 51.75 ?  448 TYR A CG  1 
ATOM   3291 C CD1 . TYR A 1 458 ? 40.239 -45.442 -31.943 1.00 49.26 ?  448 TYR A CD1 1 
ATOM   3292 C CD2 . TYR A 1 458 ? 39.924 -44.778 -34.217 1.00 51.13 ?  448 TYR A CD2 1 
ATOM   3293 C CE1 . TYR A 1 458 ? 41.582 -45.714 -32.206 1.00 54.51 ?  448 TYR A CE1 1 
ATOM   3294 C CE2 . TYR A 1 458 ? 41.256 -45.043 -34.487 1.00 56.35 ?  448 TYR A CE2 1 
ATOM   3295 C CZ  . TYR A 1 458 ? 42.082 -45.512 -33.478 1.00 54.37 ?  448 TYR A CZ  1 
ATOM   3296 O OH  . TYR A 1 458 ? 43.409 -45.784 -33.745 1.00 69.08 ?  448 TYR A OH  1 
ATOM   3297 N N   . ARG A 1 459 ? 36.447 -46.847 -30.749 1.00 67.33 ?  449 ARG A N   1 
ATOM   3298 C CA  . ARG A 1 459 ? 36.422 -47.802 -29.648 1.00 67.67 ?  449 ARG A CA  1 
ATOM   3299 C C   . ARG A 1 459 ? 35.110 -48.582 -29.644 1.00 74.51 ?  449 ARG A C   1 
ATOM   3300 O O   . ARG A 1 459 ? 34.500 -48.798 -28.594 1.00 75.37 ?  449 ARG A O   1 
ATOM   3301 C CB  . ARG A 1 459 ? 36.616 -47.071 -28.321 1.00 61.66 ?  449 ARG A CB  1 
ATOM   3302 C CG  . ARG A 1 459 ? 37.443 -45.793 -28.465 1.00 56.03 ?  449 ARG A CG  1 
ATOM   3303 C CD  . ARG A 1 459 ? 38.411 -45.608 -27.315 1.00 57.11 ?  449 ARG A CD  1 
ATOM   3304 N NE  . ARG A 1 459 ? 37.813 -45.949 -26.027 1.00 54.89 ?  449 ARG A NE  1 
ATOM   3305 C CZ  . ARG A 1 459 ? 38.498 -46.381 -24.974 1.00 62.73 ?  449 ARG A CZ  1 
ATOM   3306 N NH1 . ARG A 1 459 ? 39.806 -46.584 -25.036 1.00 62.39 ?  449 ARG A NH1 1 
ATOM   3307 N NH2 . ARG A 1 459 ? 37.856 -46.619 -23.833 1.00 60.19 ?  449 ARG A NH2 1 
ATOM   3308 N N   . LYS A 1 460 ? 34.647 -48.981 -30.828 1.00 73.96 ?  450 LYS A N   1 
ATOM   3309 C CA  . LYS A 1 460 ? 33.416 -49.757 -30.948 1.00 75.97 ?  450 LYS A CA  1 
ATOM   3310 C C   . LYS A 1 460 ? 33.592 -51.099 -30.254 1.00 86.52 ?  450 LYS A C   1 
ATOM   3311 O O   . LYS A 1 460 ? 32.686 -51.577 -29.569 1.00 93.72 ?  450 LYS A O   1 
ATOM   3312 C CB  . LYS A 1 460 ? 33.031 -49.965 -32.418 1.00 68.15 ?  450 LYS A CB  1 
ATOM   3313 O OXT . LYS A 1 460 ? 34.652 -51.722 -30.354 1.00 90.86 ?  450 LYS A OXT 1 
HETATM 3314 N N1A . ACO B 2 .   ? 45.757 -35.456 -33.989 0.87 49.49 ?  501 ACO A N1A 1 
HETATM 3315 C C2A . ACO B 2 .   ? 44.857 -36.227 -34.617 0.87 45.13 ?  501 ACO A C2A 1 
HETATM 3316 N N3A . ACO B 2 .   ? 44.777 -37.559 -34.651 0.87 44.63 ?  501 ACO A N3A 1 
HETATM 3317 C C4A . ACO B 2 .   ? 45.770 -38.117 -33.949 0.87 48.94 ?  501 ACO A C4A 1 
HETATM 3318 C C5A . ACO B 2 .   ? 46.767 -37.456 -33.249 0.87 49.10 ?  501 ACO A C5A 1 
HETATM 3319 C C6A . ACO B 2 .   ? 46.742 -36.050 -33.281 0.87 41.96 ?  501 ACO A C6A 1 
HETATM 3320 N N6A . ACO B 2 .   ? 47.641 -35.275 -32.664 0.87 43.15 ?  501 ACO A N6A 1 
HETATM 3321 N N7A . ACO B 2 .   ? 47.617 -38.362 -32.631 0.87 48.08 ?  501 ACO A N7A 1 
HETATM 3322 C C8A . ACO B 2 .   ? 47.123 -39.529 -32.970 0.87 47.76 ?  501 ACO A C8A 1 
HETATM 3323 N N9A . ACO B 2 .   ? 46.009 -39.455 -33.766 0.87 47.54 ?  501 ACO A N9A 1 
HETATM 3324 C C1B . ACO B 2 .   ? 45.228 -40.564 -34.297 0.87 53.80 ?  501 ACO A C1B 1 
HETATM 3325 C C2B . ACO B 2 .   ? 46.049 -41.594 -35.072 0.87 57.01 ?  501 ACO A C2B 1 
HETATM 3326 O O2B . ACO B 2 .   ? 46.273 -41.161 -36.410 0.87 55.04 ?  501 ACO A O2B 1 
HETATM 3327 C C3B . ACO B 2 .   ? 45.085 -42.773 -35.010 0.87 51.87 ?  501 ACO A C3B 1 
HETATM 3328 O O3B . ACO B 2 .   ? 44.013 -42.492 -35.935 0.87 58.50 ?  501 ACO A O3B 1 
HETATM 3329 P P3B . ACO B 2 .   ? 43.738 -43.422 -37.172 0.87 63.69 ?  501 ACO A P3B 1 
HETATM 3330 O O7A . ACO B 2 .   ? 42.492 -42.942 -37.833 0.87 58.60 ?  501 ACO A O7A 1 
HETATM 3331 O O8A . ACO B 2 .   ? 43.617 -44.870 -36.629 0.87 60.18 ?  501 ACO A O8A 1 
HETATM 3332 O O9A . ACO B 2 .   ? 44.975 -43.328 -38.070 0.87 63.37 ?  501 ACO A O9A 1 
HETATM 3333 C C4B . ACO B 2 .   ? 44.538 -42.687 -33.585 0.87 61.01 ?  501 ACO A C4B 1 
HETATM 3334 O O4B . ACO B 2 .   ? 44.652 -41.271 -33.215 0.87 51.18 ?  501 ACO A O4B 1 
HETATM 3335 C C5B . ACO B 2 .   ? 45.237 -43.550 -32.564 0.87 55.57 ?  501 ACO A C5B 1 
HETATM 3336 O O5B . ACO B 2 .   ? 46.489 -42.946 -32.179 0.87 62.97 ?  501 ACO A O5B 1 
HETATM 3337 P P1A . ACO B 2 .   ? 47.861 -43.692 -32.406 0.87 56.12 ?  501 ACO A P1A 1 
HETATM 3338 O O1A . ACO B 2 .   ? 48.893 -42.767 -32.917 0.87 65.81 ?  501 ACO A O1A 1 
HETATM 3339 O O2A . ACO B 2 .   ? 47.595 -44.904 -33.302 0.87 67.37 ?  501 ACO A O2A 1 
HETATM 3340 O O3A . ACO B 2 .   ? 48.262 -44.245 -30.966 0.87 61.28 ?  501 ACO A O3A 1 
HETATM 3341 P P2A . ACO B 2 .   ? 47.508 -44.731 -29.649 0.87 58.96 ?  501 ACO A P2A 1 
HETATM 3342 O O4A . ACO B 2 .   ? 48.482 -45.369 -28.741 0.87 54.71 ?  501 ACO A O4A 1 
HETATM 3343 O O5A . ACO B 2 .   ? 46.317 -45.589 -30.070 0.87 63.97 ?  501 ACO A O5A 1 
HETATM 3344 O O6A . ACO B 2 .   ? 46.913 -43.368 -29.055 0.87 66.03 ?  501 ACO A O6A 1 
HETATM 3345 C CBP . ACO B 2 .   ? 46.928 -42.063 -26.996 0.87 50.75 ?  501 ACO A CBP 1 
HETATM 3346 C CCP . ACO B 2 .   ? 47.711 -42.994 -27.922 0.87 44.02 ?  501 ACO A CCP 1 
HETATM 3347 C CDP . ACO B 2 .   ? 45.988 -42.901 -26.123 0.87 47.19 ?  501 ACO A CDP 1 
HETATM 3348 C CEP . ACO B 2 .   ? 46.101 -41.082 -27.835 0.87 35.81 ?  501 ACO A CEP 1 
HETATM 3349 C CAP . ACO B 2 .   ? 47.907 -41.272 -26.097 0.87 36.24 ?  501 ACO A CAP 1 
HETATM 3350 O OAP . ACO B 2 .   ? 48.762 -40.445 -26.874 0.87 38.58 ?  501 ACO A OAP 1 
HETATM 3351 C C9P . ACO B 2 .   ? 47.235 -40.465 -24.998 0.87 39.11 ?  501 ACO A C9P 1 
HETATM 3352 O O9P . ACO B 2 .   ? 46.865 -39.313 -25.213 0.87 37.56 ?  501 ACO A O9P 1 
HETATM 3353 N N8P . ACO B 2 .   ? 47.068 -41.065 -23.821 0.87 36.03 ?  501 ACO A N8P 1 
HETATM 3354 C C7P . ACO B 2 .   ? 46.415 -40.402 -22.706 0.87 36.12 ?  501 ACO A C7P 1 
HETATM 3355 C C6P . ACO B 2 .   ? 46.544 -41.182 -21.416 0.87 34.23 ?  501 ACO A C6P 1 
HETATM 3356 C C5P . ACO B 2 .   ? 46.304 -40.281 -20.244 0.87 39.17 ?  501 ACO A C5P 1 
HETATM 3357 O O5P . ACO B 2 .   ? 46.297 -39.058 -20.387 0.87 37.37 ?  501 ACO A O5P 1 
HETATM 3358 N N4P . ACO B 2 .   ? 46.119 -40.873 -19.066 0.87 37.36 ?  501 ACO A N4P 1 
HETATM 3359 C C3P . ACO B 2 .   ? 45.850 -40.122 -17.845 0.87 43.09 ?  501 ACO A C3P 1 
HETATM 3360 C C2P . ACO B 2 .   ? 46.055 -40.939 -16.583 0.87 42.70 ?  501 ACO A C2P 1 
HETATM 3361 S S1P . ACO B 2 .   ? 47.816 -40.859 -16.129 0.87 47.10 ?  501 ACO A S1P 1 
HETATM 3362 C C   . ACO B 2 .   ? 47.840 -39.399 -15.111 0.87 52.92 ?  501 ACO A C   1 
HETATM 3363 O O   . ACO B 2 .   ? 46.839 -38.819 -14.776 0.87 40.13 ?  501 ACO A O   1 
HETATM 3364 C CH3 . ACO B 2 .   ? 49.229 -38.972 -14.730 0.87 34.53 ?  501 ACO A CH3 1 
HETATM 3365 C C1  . CIT C 3 .   ? 46.282 -41.729 -12.400 0.79 53.37 ?  502 CIT A C1  1 
HETATM 3366 O O1  . CIT C 3 .   ? 45.731 -40.600 -12.368 0.79 48.67 ?  502 CIT A O1  1 
HETATM 3367 O O2  . CIT C 3 .   ? 45.618 -42.730 -12.770 0.79 51.53 ?  502 CIT A O2  1 
HETATM 3368 C C2  . CIT C 3 .   ? 47.727 -41.864 -11.981 0.79 41.06 ?  502 CIT A C2  1 
HETATM 3369 C C3  . CIT C 3 .   ? 47.842 -42.815 -10.793 0.79 46.35 ?  502 CIT A C3  1 
HETATM 3370 O O7  . CIT C 3 .   ? 47.373 -44.151 -11.122 0.79 44.77 ?  502 CIT A O7  1 
HETATM 3371 C C4  . CIT C 3 .   ? 47.108 -42.258 -9.583  0.79 40.79 ?  502 CIT A C4  1 
HETATM 3372 C C5  . CIT C 3 .   ? 47.033 -43.293 -8.480  0.79 45.13 ?  502 CIT A C5  1 
HETATM 3373 O O3  . CIT C 3 .   ? 47.981 -44.074 -8.239  0.79 45.81 ?  502 CIT A O3  1 
HETATM 3374 O O4  . CIT C 3 .   ? 46.002 -43.381 -7.779  0.79 53.48 ?  502 CIT A O4  1 
HETATM 3375 C C6  . CIT C 3 .   ? 49.302 -42.884 -10.423 0.79 47.16 ?  502 CIT A C6  1 
HETATM 3376 O O5  . CIT C 3 .   ? 49.808 -41.916 -9.799  0.79 41.86 ?  502 CIT A O5  1 
HETATM 3377 O O6  . CIT C 3 .   ? 49.969 -43.902 -10.732 0.79 41.13 ?  502 CIT A O6  1 
HETATM 3378 O O   . HOH D 4 .   ? 65.110 -7.778  16.240  1.00 52.13 ?  601 HOH A O   1 
HETATM 3379 O O   . HOH D 4 .   ? 68.411 -15.692 -21.531 1.00 55.48 ?  602 HOH A O   1 
HETATM 3380 O O   . HOH D 4 .   ? 57.365 -19.696 17.548  1.00 43.33 ?  603 HOH A O   1 
HETATM 3381 O O   . HOH D 4 .   ? 57.640 -6.510  6.990   1.00 52.68 ?  604 HOH A O   1 
HETATM 3382 O O   . HOH D 4 .   ? 74.843 -21.061 44.820  1.00 69.27 ?  605 HOH A O   1 
HETATM 3383 O O   . HOH D 4 .   ? 54.736 -20.236 30.558  1.00 54.10 ?  606 HOH A O   1 
HETATM 3384 O O   . HOH D 4 .   ? 40.380 -27.605 -30.037 1.00 40.88 ?  607 HOH A O   1 
HETATM 3385 O O   . HOH D 4 .   ? 68.322 -1.595  47.146  1.00 56.79 ?  608 HOH A O   1 
HETATM 3386 O O   . HOH D 4 .   ? 46.262 -15.574 28.622  1.00 48.96 ?  609 HOH A O   1 
HETATM 3387 O O   . HOH D 4 .   ? 44.902 1.549   -13.172 1.00 51.33 ?  610 HOH A O   1 
HETATM 3388 O O   . HOH D 4 .   ? 48.677 -4.259  -6.622  1.00 36.87 ?  611 HOH A O   1 
HETATM 3389 O O   . HOH D 4 .   ? 57.333 -12.979 31.453  1.00 53.22 ?  612 HOH A O   1 
HETATM 3390 O O   . HOH D 4 .   ? 42.930 -1.595  15.270  1.00 40.43 ?  613 HOH A O   1 
HETATM 3391 O O   . HOH D 4 .   ? 37.011 -20.658 2.010   1.00 45.49 ?  614 HOH A O   1 
HETATM 3392 O O   . HOH D 4 .   ? 34.965 -4.830  -1.088  1.00 46.06 ?  615 HOH A O   1 
HETATM 3393 O O   . HOH D 4 .   ? 83.730 -11.702 47.311  1.00 65.52 ?  616 HOH A O   1 
HETATM 3394 O O   . HOH D 4 .   ? 58.916 -21.085 9.854   1.00 51.86 ?  617 HOH A O   1 
HETATM 3395 O O   . HOH D 4 .   ? 45.948 -26.479 21.616  1.00 39.56 ?  618 HOH A O   1 
HETATM 3396 O O   . HOH D 4 .   ? 60.865 -20.232 17.001  1.00 33.42 ?  619 HOH A O   1 
HETATM 3397 O O   . HOH D 4 .   ? 79.860 -3.838  14.644  1.00 51.10 ?  620 HOH A O   1 
HETATM 3398 O O   . HOH D 4 .   ? 66.824 4.061   43.119  1.00 46.00 ?  621 HOH A O   1 
HETATM 3399 O O   . HOH D 4 .   ? 89.237 -3.464  33.501  1.00 52.05 ?  622 HOH A O   1 
HETATM 3400 O O   . HOH D 4 .   ? 62.512 -22.862 19.468  1.00 33.52 ?  623 HOH A O   1 
HETATM 3401 O O   . HOH D 4 .   ? 73.910 -25.766 28.308  1.00 46.83 ?  624 HOH A O   1 
HETATM 3402 O O   . HOH D 4 .   ? 58.757 -21.265 -0.616  1.00 34.86 ?  625 HOH A O   1 
HETATM 3403 O O   . HOH D 4 .   ? 86.174 -14.841 40.912  1.00 53.96 ?  626 HOH A O   1 
HETATM 3404 O O   . HOH D 4 .   ? 71.683 -19.789 31.612  1.00 51.22 ?  627 HOH A O   1 
HETATM 3405 O O   . HOH D 4 .   ? 43.907 -19.568 17.368  1.00 28.45 ?  628 HOH A O   1 
HETATM 3406 O O   . HOH D 4 .   ? 35.989 -8.172  -2.122  1.00 48.41 ?  629 HOH A O   1 
HETATM 3407 O O   . HOH D 4 .   ? 36.039 -6.710  -16.480 1.00 43.47 ?  630 HOH A O   1 
HETATM 3408 O O   . HOH D 4 .   ? 37.821 -9.307  -16.593 1.00 37.72 ?  631 HOH A O   1 
HETATM 3409 O O   . HOH D 4 .   ? 70.951 -12.302 31.278  1.00 44.08 ?  632 HOH A O   1 
HETATM 3410 O O   . HOH D 4 .   ? 74.878 -13.457 40.881  1.00 47.88 ?  633 HOH A O   1 
HETATM 3411 O O   . HOH D 4 .   ? 45.092 -24.349 -34.868 1.00 48.01 ?  634 HOH A O   1 
HETATM 3412 O O   . HOH D 4 .   ? 39.560 -21.345 7.870   1.00 35.44 ?  635 HOH A O   1 
HETATM 3413 O O   . HOH D 4 .   ? 35.674 -12.201 17.560  1.00 29.34 ?  636 HOH A O   1 
HETATM 3414 O O   . HOH D 4 .   ? 54.398 -15.989 30.102  1.00 43.47 ?  637 HOH A O   1 
HETATM 3415 O O   . HOH D 4 .   ? 50.985 -41.747 -27.418 1.00 50.29 ?  638 HOH A O   1 
HETATM 3416 O O   . HOH D 4 .   ? 61.472 -13.082 48.466  1.00 54.36 ?  639 HOH A O   1 
HETATM 3417 O O   . HOH D 4 .   ? 66.437 -10.713 50.652  1.00 50.48 ?  640 HOH A O   1 
HETATM 3418 O O   . HOH D 4 .   ? 51.236 -9.862  27.864  1.00 35.94 ?  641 HOH A O   1 
HETATM 3419 O O   . HOH D 4 .   ? 43.368 -27.684 -35.954 1.00 51.09 ?  642 HOH A O   1 
HETATM 3420 O O   . HOH D 4 .   ? 57.783 -22.896 -6.351  1.00 33.30 ?  643 HOH A O   1 
HETATM 3421 O O   . HOH D 4 .   ? 72.155 -16.875 31.924  1.00 45.24 ?  644 HOH A O   1 
HETATM 3422 O O   . HOH D 4 .   ? 60.357 -9.346  -12.219 1.00 48.45 ?  645 HOH A O   1 
HETATM 3423 O O   . HOH D 4 .   ? 43.901 -22.606 24.566  1.00 48.40 ?  646 HOH A O   1 
HETATM 3424 O O   . HOH D 4 .   ? 60.099 -11.980 41.812  1.00 49.07 ?  647 HOH A O   1 
HETATM 3425 O O   . HOH D 4 .   ? 46.813 -1.549  -19.460 1.00 49.12 ?  648 HOH A O   1 
HETATM 3426 O O   . HOH D 4 .   ? 74.695 -24.489 21.684  1.00 46.69 ?  649 HOH A O   1 
HETATM 3427 O O   . HOH D 4 .   ? 40.810 -17.386 -2.102  1.00 37.12 ?  650 HOH A O   1 
HETATM 3428 O O   . HOH D 4 .   ? 57.420 -15.279 -26.428 1.00 39.99 ?  651 HOH A O   1 
HETATM 3429 O O   . HOH D 4 .   ? 64.491 -14.774 29.922  1.00 37.18 ?  652 HOH A O   1 
HETATM 3430 O O   . HOH D 4 .   ? 52.279 -16.277 20.340  1.00 35.58 ?  653 HOH A O   1 
HETATM 3431 O O   . HOH D 4 .   ? 76.220 4.240   36.752  1.00 48.09 ?  654 HOH A O   1 
HETATM 3432 O O   . HOH D 4 .   ? 61.887 -10.568 25.969  1.00 38.56 ?  655 HOH A O   1 
HETATM 3433 O O   . HOH D 4 .   ? 53.489 -9.327  18.731  1.00 30.53 ?  656 HOH A O   1 
HETATM 3434 O O   . HOH D 4 .   ? 42.623 -32.323 -34.886 1.00 42.23 ?  657 HOH A O   1 
HETATM 3435 O O   . HOH D 4 .   ? 80.896 6.089   35.042  1.00 57.59 ?  658 HOH A O   1 
HETATM 3436 O O   . HOH D 4 .   ? 77.666 5.919   40.631  1.00 55.41 ?  659 HOH A O   1 
HETATM 3437 O O   . HOH D 4 .   ? 59.949 -14.085 5.060   1.00 40.01 ?  660 HOH A O   1 
HETATM 3438 O O   . HOH D 4 .   ? 47.045 -6.072  18.879  1.00 34.37 ?  661 HOH A O   1 
HETATM 3439 O O   . HOH D 4 .   ? 62.495 -21.226 15.151  1.00 40.07 ?  662 HOH A O   1 
HETATM 3440 O O   . HOH D 4 .   ? 54.459 -23.786 6.160   1.00 34.50 ?  663 HOH A O   1 
HETATM 3441 O O   . HOH D 4 .   ? 36.715 -17.694 11.890  1.00 47.07 ?  664 HOH A O   1 
HETATM 3442 O O   . HOH D 4 .   ? 56.782 -13.532 -16.454 1.00 33.45 ?  665 HOH A O   1 
HETATM 3443 O O   . HOH D 4 .   ? 38.998 -20.038 -2.078  1.00 31.44 ?  666 HOH A O   1 
HETATM 3444 O O   . HOH D 4 .   ? 39.496 -8.185  24.691  1.00 37.07 ?  667 HOH A O   1 
HETATM 3445 O O   . HOH D 4 .   ? 60.117 -17.334 -21.086 1.00 36.04 ?  668 HOH A O   1 
HETATM 3446 O O   . HOH D 4 .   ? 43.623 -38.134 -37.117 1.00 53.81 ?  669 HOH A O   1 
HETATM 3447 O O   . HOH D 4 .   ? 46.282 -27.869 -29.202 1.00 51.20 ?  670 HOH A O   1 
HETATM 3448 O O   . HOH D 4 .   ? 48.557 -26.067 -15.753 1.00 40.02 ?  671 HOH A O   1 
HETATM 3449 O O   . HOH D 4 .   ? 48.264 -26.064 -13.184 1.00 42.97 ?  672 HOH A O   1 
HETATM 3450 O O   . HOH D 4 .   ? 53.554 -2.855  -10.835 1.00 50.13 ?  673 HOH A O   1 
HETATM 3451 O O   . HOH D 4 .   ? 40.457 -16.932 -11.865 1.00 41.98 ?  674 HOH A O   1 
HETATM 3452 O O   . HOH D 4 .   ? 59.532 -13.327 14.828  1.00 36.27 ?  675 HOH A O   1 
HETATM 3453 O O   . HOH D 4 .   ? 49.255 -4.693  -1.730  1.00 37.84 ?  676 HOH A O   1 
HETATM 3454 O O   . HOH D 4 .   ? 66.581 -5.214  55.386  1.00 60.69 ?  677 HOH A O   1 
HETATM 3455 O O   . HOH D 4 .   ? 71.189 -32.483 26.924  1.00 43.12 ?  678 HOH A O   1 
HETATM 3456 O O   . HOH D 4 .   ? 56.427 -7.023  -7.011  1.00 45.43 ?  679 HOH A O   1 
HETATM 3457 O O   . HOH D 4 .   ? 76.376 -12.486 35.327  1.00 53.93 ?  680 HOH A O   1 
HETATM 3458 O O   . HOH D 4 .   ? 47.585 -2.094  -23.676 1.00 44.41 ?  681 HOH A O   1 
HETATM 3459 O O   . HOH D 4 .   ? 57.897 -11.059 15.142  1.00 33.86 ?  682 HOH A O   1 
HETATM 3460 O O   . HOH D 4 .   ? 48.805 -25.414 -22.410 1.00 36.14 ?  683 HOH A O   1 
HETATM 3461 O O   . HOH D 4 .   ? 46.884 -5.552  25.616  1.00 39.93 ?  684 HOH A O   1 
HETATM 3462 O O   . HOH D 4 .   ? 57.152 -18.188 21.387  1.00 38.93 ?  685 HOH A O   1 
HETATM 3463 O O   . HOH D 4 .   ? 79.028 -15.219 37.646  1.00 56.04 ?  686 HOH A O   1 
HETATM 3464 O O   . HOH D 4 .   ? 76.339 -27.619 22.376  1.00 43.58 ?  687 HOH A O   1 
HETATM 3465 O O   . HOH D 4 .   ? 57.058 -8.070  -20.962 1.00 51.57 ?  688 HOH A O   1 
HETATM 3466 O O   . HOH D 4 .   ? 56.912 -21.778 30.072  1.00 39.75 ?  689 HOH A O   1 
HETATM 3467 O O   . HOH D 4 .   ? 74.877 5.509   39.415  1.00 50.68 ?  690 HOH A O   1 
HETATM 3468 O O   . HOH D 4 .   ? 38.199 -2.701  -1.023  1.00 37.95 ?  691 HOH A O   1 
HETATM 3469 O O   . HOH D 4 .   ? 58.327 -5.988  38.325  1.00 47.38 ?  692 HOH A O   1 
HETATM 3470 O O   . HOH D 4 .   ? 87.434 -18.924 46.828  1.00 64.75 ?  693 HOH A O   1 
HETATM 3471 O O   . HOH D 4 .   ? 37.730 -10.668 11.568  1.00 28.97 ?  694 HOH A O   1 
HETATM 3472 O O   . HOH D 4 .   ? 53.142 -19.026 -31.689 1.00 49.49 ?  695 HOH A O   1 
HETATM 3473 O O   . HOH D 4 .   ? 65.495 -29.078 31.496  1.00 48.29 ?  696 HOH A O   1 
HETATM 3474 O O   . HOH D 4 .   ? 60.292 -4.932  36.647  1.00 51.58 ?  697 HOH A O   1 
HETATM 3475 O O   . HOH D 4 .   ? 48.802 -4.162  -16.463 1.00 35.37 ?  698 HOH A O   1 
HETATM 3476 O O   . HOH D 4 .   ? 45.090 -21.898 -32.958 1.00 39.73 ?  699 HOH A O   1 
HETATM 3477 O O   . HOH D 4 .   ? 80.899 -26.001 15.556  1.00 54.26 ?  700 HOH A O   1 
HETATM 3478 O O   . HOH D 4 .   ? 63.067 -8.002  23.044  1.00 50.95 ?  701 HOH A O   1 
HETATM 3479 O O   . HOH D 4 .   ? 36.723 -8.189  -10.544 1.00 48.42 ?  702 HOH A O   1 
HETATM 3480 O O   . HOH D 4 .   ? 56.314 -18.059 0.595   1.00 26.52 ?  703 HOH A O   1 
HETATM 3481 O O   . HOH D 4 .   ? 63.287 -27.384 21.783  1.00 30.65 ?  704 HOH A O   1 
HETATM 3482 O O   . HOH D 4 .   ? 36.426 -6.576  -21.215 1.00 47.22 ?  705 HOH A O   1 
HETATM 3483 O O   . HOH D 4 .   ? 43.506 -19.431 -11.941 1.00 30.06 ?  706 HOH A O   1 
HETATM 3484 O O   . HOH D 4 .   ? 80.110 -16.617 20.576  1.00 44.78 ?  707 HOH A O   1 
HETATM 3485 O O   . HOH D 4 .   ? 69.521 -25.418 34.063  1.00 41.48 ?  708 HOH A O   1 
HETATM 3486 O O   . HOH D 4 .   ? 77.582 -20.813 15.976  1.00 48.00 ?  709 HOH A O   1 
HETATM 3487 O O   . HOH D 4 .   ? 61.508 -9.136  -19.430 1.00 41.81 ?  710 HOH A O   1 
HETATM 3488 O O   . HOH D 4 .   ? 45.687 -26.667 16.393  1.00 33.81 ?  711 HOH A O   1 
HETATM 3489 O O   . HOH D 4 .   ? 66.075 4.216   32.796  1.00 43.72 ?  712 HOH A O   1 
HETATM 3490 O O   . HOH D 4 .   ? 57.795 -20.147 4.947   1.00 33.68 ?  713 HOH A O   1 
HETATM 3491 O O   . HOH D 4 .   ? 39.508 -1.584  -19.928 1.00 52.50 ?  714 HOH A O   1 
HETATM 3492 O O   . HOH D 4 .   ? 33.483 -36.761 -36.469 1.00 59.16 ?  715 HOH A O   1 
HETATM 3493 O O   . HOH D 4 .   ? 44.223 -1.927  -0.096  1.00 36.70 ?  716 HOH A O   1 
HETATM 3494 O O   . HOH D 4 .   ? 76.319 -18.572 23.158  1.00 45.99 ?  717 HOH A O   1 
HETATM 3495 O O   . HOH D 4 .   ? 57.953 -28.219 27.094  1.00 48.65 ?  718 HOH A O   1 
HETATM 3496 O O   . HOH D 4 .   ? 38.020 -10.621 -2.586  1.00 46.49 ?  719 HOH A O   1 
HETATM 3497 O O   . HOH D 4 .   ? 42.830 0.600   -27.359 1.00 60.11 ?  720 HOH A O   1 
HETATM 3498 O O   . HOH D 4 .   ? 73.349 -13.000 33.347  1.00 51.80 ?  721 HOH A O   1 
HETATM 3499 O O   . HOH D 4 .   ? 68.229 2.881   51.140  1.00 55.64 ?  722 HOH A O   1 
HETATM 3500 O O   . HOH D 4 .   ? 39.107 -2.860  -9.806  1.00 45.19 ?  723 HOH A O   1 
HETATM 3501 O O   . HOH D 4 .   ? 56.515 -24.472 23.442  1.00 40.79 ?  724 HOH A O   1 
HETATM 3502 O O   . HOH D 4 .   ? 47.570 -1.173  19.371  1.00 56.27 ?  725 HOH A O   1 
HETATM 3503 O O   . HOH D 4 .   ? 39.357 -25.100 -30.997 1.00 47.22 ?  726 HOH A O   1 
HETATM 3504 O O   . HOH D 4 .   ? 47.043 -20.150 27.243  1.00 61.03 ?  727 HOH A O   1 
HETATM 3505 O O   . HOH D 4 .   ? 38.032 -10.953 2.304   1.00 41.37 ?  728 HOH A O   1 
HETATM 3506 O O   . HOH D 4 .   ? 48.879 -4.305  -21.230 1.00 44.47 ?  729 HOH A O   1 
HETATM 3507 O O   . HOH D 4 .   ? 62.759 1.508   42.263  1.00 58.86 ?  730 HOH A O   1 
HETATM 3508 O O   . HOH D 4 .   ? 57.115 -23.605 -3.761  1.00 29.45 ?  731 HOH A O   1 
HETATM 3509 O O   . HOH D 4 .   ? 28.235 -43.865 -30.599 1.00 47.84 ?  732 HOH A O   1 
HETATM 3510 O O   . HOH D 4 .   ? 60.687 -6.197  25.936  1.00 46.24 ?  733 HOH A O   1 
HETATM 3511 O O   . HOH D 4 .   ? 36.438 -10.019 15.860  1.00 38.43 ?  734 HOH A O   1 
HETATM 3512 O O   . HOH D 4 .   ? 61.633 -10.180 23.352  1.00 52.58 ?  735 HOH A O   1 
HETATM 3513 O O   . HOH D 4 .   ? 69.332 -19.595 14.211  1.00 58.40 ?  736 HOH A O   1 
HETATM 3514 O O   . HOH D 4 .   ? 49.429 -4.983  17.760  1.00 32.42 ?  737 HOH A O   1 
HETATM 3515 O O   . HOH D 4 .   ? 37.878 -10.805 6.776   1.00 38.73 ?  738 HOH A O   1 
HETATM 3516 O O   . HOH D 4 .   ? 45.038 -1.475  -8.396  1.00 44.39 ?  739 HOH A O   1 
HETATM 3517 O O   . HOH D 4 .   ? 82.408 7.474   37.894  1.00 56.71 ?  740 HOH A O   1 
HETATM 3518 O O   . HOH D 4 .   ? 66.271 -22.612 16.622  1.00 35.78 ?  741 HOH A O   1 
HETATM 3519 O O   . HOH D 4 .   ? 56.356 -11.271 -27.362 1.00 51.01 ?  742 HOH A O   1 
HETATM 3520 O O   . HOH D 4 .   ? 76.573 -17.048 26.625  1.00 52.55 ?  743 HOH A O   1 
HETATM 3521 O O   . HOH D 4 .   ? 60.941 -13.669 -5.204  1.00 44.17 ?  744 HOH A O   1 
HETATM 3522 O O   . HOH D 4 .   ? 87.517 2.406   34.221  1.00 48.83 ?  745 HOH A O   1 
HETATM 3523 O O   . HOH D 4 .   ? 47.990 -27.707 -20.910 0.33 36.00 ?  746 HOH A O   1 
HETATM 3524 O O   . HOH D 4 .   ? 47.093 -2.205  -27.964 1.00 43.25 ?  747 HOH A O   1 
HETATM 3525 O O   . HOH D 4 .   ? 57.254 -8.393  -25.684 1.00 53.80 ?  748 HOH A O   1 
HETATM 3526 O O   . HOH D 4 .   ? 78.040 -25.008 28.744  1.00 54.01 ?  749 HOH A O   1 
HETATM 3527 O O   . HOH D 4 .   ? 56.197 -17.227 17.401  1.00 35.70 ?  750 HOH A O   1 
HETATM 3528 O O   . HOH D 4 .   ? 38.523 -17.170 21.320  1.00 33.14 ?  751 HOH A O   1 
HETATM 3529 O O   . HOH D 4 .   ? 71.594 -20.970 34.611  1.00 52.29 ?  752 HOH A O   1 
HETATM 3530 O O   . HOH D 4 .   ? 58.407 -28.849 29.574  1.00 48.79 ?  753 HOH A O   1 
HETATM 3531 O O   . HOH D 4 .   ? 84.642 -13.502 12.267  1.00 59.77 ?  754 HOH A O   1 
HETATM 3532 O O   . HOH D 4 .   ? 75.887 -0.296  19.050  1.00 61.48 ?  755 HOH A O   1 
HETATM 3533 O O   . HOH D 4 .   ? 43.107 -11.331 31.883  1.00 42.97 ?  756 HOH A O   1 
HETATM 3534 O O   . HOH D 4 .   ? 62.240 -9.307  20.354  1.00 51.18 ?  757 HOH A O   1 
HETATM 3535 O O   . HOH D 4 .   ? 77.422 -22.280 28.633  1.00 61.24 ?  758 HOH A O   1 
HETATM 3536 O O   . HOH D 4 .   ? 48.721 -18.590 25.129  1.00 46.61 ?  759 HOH A O   1 
HETATM 3537 O O   . HOH D 4 .   ? 55.326 -16.904 19.793  1.00 43.43 ?  760 HOH A O   1 
HETATM 3538 O O   . HOH D 4 .   ? 75.423 -1.377  51.156  1.00 61.62 ?  761 HOH A O   1 
HETATM 3539 O O   . HOH D 4 .   ? 63.966 3.596   43.518  1.00 60.28 ?  762 HOH A O   1 
HETATM 3540 O O   . HOH D 4 .   ? 62.178 -13.409 10.057  1.00 57.70 ?  763 HOH A O   1 
HETATM 3541 O O   . HOH D 4 .   ? 36.072 -11.996 -12.807 1.00 63.12 ?  764 HOH A O   1 
HETATM 3542 O O   . HOH D 4 .   ? 45.405 -3.024  25.913  1.00 59.76 ?  765 HOH A O   1 
HETATM 3543 O O   . HOH D 4 .   ? 63.665 -9.913  -14.083 1.00 58.07 ?  766 HOH A O   1 
HETATM 3544 O O   . HOH D 4 .   ? 37.768 -4.125  -7.869  1.00 43.47 ?  767 HOH A O   1 
HETATM 3545 O O   . HOH D 4 .   ? 63.553 -22.953 16.837  1.00 32.47 ?  768 HOH A O   1 
HETATM 3546 O O   . HOH D 4 .   ? 62.786 -15.772 10.292  1.00 58.88 ?  769 HOH A O   1 
HETATM 3547 O O   . HOH D 4 .   ? 48.904 -8.865  28.774  1.00 51.22 ?  770 HOH A O   1 
HETATM 3548 O O   . HOH D 4 .   ? 39.950 -17.650 6.274   1.00 44.26 ?  771 HOH A O   1 
HETATM 3549 O O   . HOH D 4 .   ? 67.279 -22.199 14.248  1.00 48.99 ?  772 HOH A O   1 
HETATM 3550 O O   . HOH D 4 .   ? 47.413 -2.279  -6.910  1.00 50.99 ?  773 HOH A O   1 
HETATM 3551 O O   . HOH D 4 .   ? 47.189 -1.895  13.768  1.00 50.91 ?  774 HOH A O   1 
HETATM 3552 O O   . HOH D 4 .   ? 46.430 -2.467  -2.198  1.00 55.19 ?  775 HOH A O   1 
HETATM 3553 O O   . HOH D 4 .   ? 77.298 -13.437 37.310  1.00 59.31 ?  776 HOH A O   1 
HETATM 3554 O O   . HOH D 4 .   ? 53.768 -8.621  23.820  1.00 46.92 ?  777 HOH A O   1 
HETATM 3555 O O   . HOH D 4 .   ? 53.672 -8.009  21.332  1.00 51.23 ?  778 HOH A O   1 
HETATM 3556 O O   . HOH D 4 .   ? 60.794 -19.445 4.049   1.00 53.03 ?  779 HOH A O   1 
HETATM 3557 O O   . HOH D 4 .   ? 78.855 -16.453 39.966  1.00 57.85 ?  780 HOH A O   1 
HETATM 3558 O O   . HOH D 4 .   ? 75.551 -14.177 38.658  1.00 54.41 ?  781 HOH A O   1 
HETATM 3559 O O   . HOH D 4 .   ? 35.612 -11.810 11.672  1.00 53.24 ?  782 HOH A O   1 
HETATM 3560 O O   . HOH D 4 .   ? 51.816 -11.326 30.251  1.00 52.04 ?  783 HOH A O   1 
HETATM 3561 O O   . HOH D 4 .   ? 65.106 -22.821 11.662  1.00 53.85 ?  784 HOH A O   1 
HETATM 3562 O O   . HOH D 4 .   ? 47.990 -27.707 17.100  0.33 29.21 ?  785 HOH A O   1 
HETATM 3563 O O   . HOH D 4 .   ? 68.858 -0.723  16.821  1.00 55.47 ?  786 HOH A O   1 
HETATM 3564 O O   . HOH D 4 .   ? 48.226 -6.064  28.002  1.00 43.03 ?  787 HOH A O   1 
HETATM 3565 O O   . HOH D 4 .   ? 40.012 -0.653  -1.142  1.00 51.61 ?  788 HOH A O   1 
HETATM 3566 O O   . HOH D 4 .   ? 60.652 -7.132  -20.888 1.00 54.37 ?  789 HOH A O   1 
HETATM 3567 O O   . HOH D 4 .   ? 32.559 -19.044 2.809   1.00 56.08 ?  790 HOH A O   1 
# 
