data_9DQ3
# 
_entry.id   9DQ3 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQ3         pdb_00009dq3 10.2210/pdb9dq3/pdb 
WWPDB D_1000288034 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQ3 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              sjdiong0405@gmail.com 
_pdbx_contact_author.name_first         SJ 
_pdbx_contact_author.name_last          Diong 
_pdbx_contact_author.name_mi            J 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4516-8355 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Diong, S.J.' 1 0000-0002-4516-8355 
'Lee, P.S.'   2 0000-0002-8745-4034 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Mabs 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1942-0870 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            17 
_citation.language                  ? 
_citation.page_first                2451296 
_citation.page_last                 2451296 
_citation.title                     'Engineered ipilimumab variants that bind human and mouse CTLA-4.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1080/19420862.2025.2451296 
_citation.pdbx_database_id_PubMed   39849917 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Robison, B.'  1  0000-0003-1159-9808 
primary 'Diong, S.J.'  2  0000-0002-4516-8355 
primary 'Kumar, A.'    3  ?                   
primary 'Moon, T.M.'   4  ?                   
primary 'Chang, O.'    5  ?                   
primary 'Chau, B.'     6  ?                   
primary 'Bee, C.'      7  ?                   
primary 'Barman, I.'   8  ?                   
primary 'Rajpal, A.'   9  ?                   
primary 'Korman, A.J.' 10 ?                   
primary 'West, S.'     11 ?                   
primary 'Strop, P.'    12 ?                   
primary 'Lee, P.S.'    13 0000-0002-8745-4034 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Cytotoxic T-lymphocyte protein 4' 13555.421 1   ? ? 'Extracellular domain of human CTLA-4 with hexahistidine tag' ? 
2 polymer man 'mipi.4 heavy chain'               24708.742 1   ? ? ?                                                             ? 
3 polymer man 'mipi.4 light chain'               23608.199 1   ? ? ?                                                             ? 
4 water   nat water                              18.015    321 ? ? ?                                                             ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLT
IQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDGHHHHHH
;
;KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLT
IQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDGHHHHHH
;
C ? 
2 'polypeptide(L)' no no 
;QVQLVESGGGVVQPGRSLRLSCAASGFTFSKYVMHWVRQAPGKGLEWVTGISYDGRHKYYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH
;
;QVQLVESGGGVVQPGRSLRLSCAASGFTFSKYVMHWVRQAPGKGLEWVTGISYDGRHKYYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH
;
H ? 
3 'polypeptide(L)' no no 
;EIVLTQSPGTLSLSPGERATLSCRQSQSVGWSPLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLE
PEDFAVYYCQQYGQSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;EIVLTQSPGTLSLSPGERATLSCRQSQSVGWSPLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLE
PEDFAVYYCQQYGQSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
L ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   ALA n 
1 3   MET n 
1 4   HIS n 
1 5   VAL n 
1 6   ALA n 
1 7   GLN n 
1 8   PRO n 
1 9   ALA n 
1 10  VAL n 
1 11  VAL n 
1 12  LEU n 
1 13  ALA n 
1 14  SER n 
1 15  SER n 
1 16  ARG n 
1 17  GLY n 
1 18  ILE n 
1 19  ALA n 
1 20  SER n 
1 21  PHE n 
1 22  VAL n 
1 23  CYS n 
1 24  GLU n 
1 25  TYR n 
1 26  ALA n 
1 27  SER n 
1 28  PRO n 
1 29  GLY n 
1 30  LYS n 
1 31  ALA n 
1 32  THR n 
1 33  GLU n 
1 34  VAL n 
1 35  ARG n 
1 36  VAL n 
1 37  THR n 
1 38  VAL n 
1 39  LEU n 
1 40  ARG n 
1 41  GLN n 
1 42  ALA n 
1 43  ASP n 
1 44  SER n 
1 45  GLN n 
1 46  VAL n 
1 47  THR n 
1 48  GLU n 
1 49  VAL n 
1 50  CYS n 
1 51  ALA n 
1 52  ALA n 
1 53  THR n 
1 54  TYR n 
1 55  MET n 
1 56  MET n 
1 57  GLY n 
1 58  ASN n 
1 59  GLU n 
1 60  LEU n 
1 61  THR n 
1 62  PHE n 
1 63  LEU n 
1 64  ASP n 
1 65  ASP n 
1 66  SER n 
1 67  ILE n 
1 68  CYS n 
1 69  THR n 
1 70  GLY n 
1 71  THR n 
1 72  SER n 
1 73  SER n 
1 74  GLY n 
1 75  ASN n 
1 76  GLN n 
1 77  VAL n 
1 78  ASN n 
1 79  LEU n 
1 80  THR n 
1 81  ILE n 
1 82  GLN n 
1 83  GLY n 
1 84  LEU n 
1 85  ARG n 
1 86  ALA n 
1 87  MET n 
1 88  ASP n 
1 89  THR n 
1 90  GLY n 
1 91  LEU n 
1 92  TYR n 
1 93  ILE n 
1 94  CYS n 
1 95  LYS n 
1 96  VAL n 
1 97  GLU n 
1 98  LEU n 
1 99  MET n 
1 100 TYR n 
1 101 PRO n 
1 102 PRO n 
1 103 PRO n 
1 104 TYR n 
1 105 TYR n 
1 106 LEU n 
1 107 GLY n 
1 108 ILE n 
1 109 GLY n 
1 110 ASN n 
1 111 GLY n 
1 112 THR n 
1 113 GLN n 
1 114 ILE n 
1 115 TYR n 
1 116 VAL n 
1 117 ILE n 
1 118 ASP n 
1 119 GLY n 
1 120 HIS n 
1 121 HIS n 
1 122 HIS n 
1 123 HIS n 
1 124 HIS n 
1 125 HIS n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   VAL n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  VAL n 
2 12  VAL n 
2 13  GLN n 
2 14  PRO n 
2 15  GLY n 
2 16  ARG n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  ALA n 
2 24  ALA n 
2 25  SER n 
2 26  GLY n 
2 27  PHE n 
2 28  THR n 
2 29  PHE n 
2 30  SER n 
2 31  LYS n 
2 32  TYR n 
2 33  VAL n 
2 34  MET n 
2 35  HIS n 
2 36  TRP n 
2 37  VAL n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLY n 
2 45  LEU n 
2 46  GLU n 
2 47  TRP n 
2 48  VAL n 
2 49  THR n 
2 50  GLY n 
2 51  ILE n 
2 52  SER n 
2 53  TYR n 
2 54  ASP n 
2 55  GLY n 
2 56  ARG n 
2 57  HIS n 
2 58  LYS n 
2 59  TYR n 
2 60  TYR n 
2 61  ALA n 
2 62  ASP n 
2 63  SER n 
2 64  VAL n 
2 65  LYS n 
2 66  GLY n 
2 67  ARG n 
2 68  PHE n 
2 69  THR n 
2 70  ILE n 
2 71  SER n 
2 72  ARG n 
2 73  ASP n 
2 74  ASN n 
2 75  SER n 
2 76  LYS n 
2 77  ASN n 
2 78  THR n 
2 79  LEU n 
2 80  TYR n 
2 81  LEU n 
2 82  GLN n 
2 83  MET n 
2 84  ASN n 
2 85  SER n 
2 86  LEU n 
2 87  ARG n 
2 88  ALA n 
2 89  GLU n 
2 90  ASP n 
2 91  THR n 
2 92  ALA n 
2 93  ILE n 
2 94  TYR n 
2 95  TYR n 
2 96  CYS n 
2 97  ALA n 
2 98  ARG n 
2 99  THR n 
2 100 GLY n 
2 101 TRP n 
2 102 LEU n 
2 103 GLY n 
2 104 PRO n 
2 105 PHE n 
2 106 ASP n 
2 107 TYR n 
2 108 TRP n 
2 109 GLY n 
2 110 GLN n 
2 111 GLY n 
2 112 THR n 
2 113 LEU n 
2 114 VAL n 
2 115 THR n 
2 116 VAL n 
2 117 SER n 
2 118 SER n 
2 119 ALA n 
2 120 SER n 
2 121 THR n 
2 122 LYS n 
2 123 GLY n 
2 124 PRO n 
2 125 SER n 
2 126 VAL n 
2 127 PHE n 
2 128 PRO n 
2 129 LEU n 
2 130 ALA n 
2 131 PRO n 
2 132 SER n 
2 133 SER n 
2 134 LYS n 
2 135 SER n 
2 136 THR n 
2 137 SER n 
2 138 GLY n 
2 139 GLY n 
2 140 THR n 
2 141 ALA n 
2 142 ALA n 
2 143 LEU n 
2 144 GLY n 
2 145 CYS n 
2 146 LEU n 
2 147 VAL n 
2 148 LYS n 
2 149 ASP n 
2 150 TYR n 
2 151 PHE n 
2 152 PRO n 
2 153 GLU n 
2 154 PRO n 
2 155 VAL n 
2 156 THR n 
2 157 VAL n 
2 158 SER n 
2 159 TRP n 
2 160 ASN n 
2 161 SER n 
2 162 GLY n 
2 163 ALA n 
2 164 LEU n 
2 165 THR n 
2 166 SER n 
2 167 GLY n 
2 168 VAL n 
2 169 HIS n 
2 170 THR n 
2 171 PHE n 
2 172 PRO n 
2 173 ALA n 
2 174 VAL n 
2 175 LEU n 
2 176 GLN n 
2 177 SER n 
2 178 SER n 
2 179 GLY n 
2 180 LEU n 
2 181 TYR n 
2 182 SER n 
2 183 LEU n 
2 184 SER n 
2 185 SER n 
2 186 VAL n 
2 187 VAL n 
2 188 THR n 
2 189 VAL n 
2 190 PRO n 
2 191 SER n 
2 192 SER n 
2 193 SER n 
2 194 LEU n 
2 195 GLY n 
2 196 THR n 
2 197 GLN n 
2 198 THR n 
2 199 TYR n 
2 200 ILE n 
2 201 CYS n 
2 202 ASN n 
2 203 VAL n 
2 204 ASN n 
2 205 HIS n 
2 206 LYS n 
2 207 PRO n 
2 208 SER n 
2 209 ASN n 
2 210 THR n 
2 211 LYS n 
2 212 VAL n 
2 213 ASP n 
2 214 LYS n 
2 215 ARG n 
2 216 VAL n 
2 217 GLU n 
2 218 PRO n 
2 219 LYS n 
2 220 SER n 
2 221 CYS n 
2 222 GLY n 
2 223 GLY n 
2 224 HIS n 
2 225 HIS n 
2 226 HIS n 
2 227 HIS n 
2 228 HIS n 
2 229 HIS n 
3 1   GLU n 
3 2   ILE n 
3 3   VAL n 
3 4   LEU n 
3 5   THR n 
3 6   GLN n 
3 7   SER n 
3 8   PRO n 
3 9   GLY n 
3 10  THR n 
3 11  LEU n 
3 12  SER n 
3 13  LEU n 
3 14  SER n 
3 15  PRO n 
3 16  GLY n 
3 17  GLU n 
3 18  ARG n 
3 19  ALA n 
3 20  THR n 
3 21  LEU n 
3 22  SER n 
3 23  CYS n 
3 24  ARG n 
3 25  GLN n 
3 26  SER n 
3 27  GLN n 
3 28  SER n 
3 29  VAL n 
3 30  GLY n 
3 31  TRP n 
3 32  SER n 
3 33  PRO n 
3 34  LEU n 
3 35  ALA n 
3 36  TRP n 
3 37  TYR n 
3 38  GLN n 
3 39  GLN n 
3 40  LYS n 
3 41  PRO n 
3 42  GLY n 
3 43  GLN n 
3 44  ALA n 
3 45  PRO n 
3 46  ARG n 
3 47  LEU n 
3 48  LEU n 
3 49  ILE n 
3 50  TYR n 
3 51  GLY n 
3 52  ALA n 
3 53  PHE n 
3 54  SER n 
3 55  ARG n 
3 56  ALA n 
3 57  THR n 
3 58  GLY n 
3 59  ILE n 
3 60  PRO n 
3 61  ASP n 
3 62  ARG n 
3 63  PHE n 
3 64  SER n 
3 65  GLY n 
3 66  SER n 
3 67  GLY n 
3 68  SER n 
3 69  GLY n 
3 70  THR n 
3 71  ASP n 
3 72  PHE n 
3 73  THR n 
3 74  LEU n 
3 75  THR n 
3 76  ILE n 
3 77  SER n 
3 78  ARG n 
3 79  LEU n 
3 80  GLU n 
3 81  PRO n 
3 82  GLU n 
3 83  ASP n 
3 84  PHE n 
3 85  ALA n 
3 86  VAL n 
3 87  TYR n 
3 88  TYR n 
3 89  CYS n 
3 90  GLN n 
3 91  GLN n 
3 92  TYR n 
3 93  GLY n 
3 94  GLN n 
3 95  SER n 
3 96  PRO n 
3 97  TRP n 
3 98  THR n 
3 99  PHE n 
3 100 GLY n 
3 101 GLN n 
3 102 GLY n 
3 103 THR n 
3 104 LYS n 
3 105 VAL n 
3 106 GLU n 
3 107 ILE n 
3 108 LYS n 
3 109 ARG n 
3 110 THR n 
3 111 VAL n 
3 112 ALA n 
3 113 ALA n 
3 114 PRO n 
3 115 SER n 
3 116 VAL n 
3 117 PHE n 
3 118 ILE n 
3 119 PHE n 
3 120 PRO n 
3 121 PRO n 
3 122 SER n 
3 123 ASP n 
3 124 GLU n 
3 125 GLN n 
3 126 LEU n 
3 127 LYS n 
3 128 SER n 
3 129 GLY n 
3 130 THR n 
3 131 ALA n 
3 132 SER n 
3 133 VAL n 
3 134 VAL n 
3 135 CYS n 
3 136 LEU n 
3 137 LEU n 
3 138 ASN n 
3 139 ASN n 
3 140 PHE n 
3 141 TYR n 
3 142 PRO n 
3 143 ARG n 
3 144 GLU n 
3 145 ALA n 
3 146 LYS n 
3 147 VAL n 
3 148 GLN n 
3 149 TRP n 
3 150 LYS n 
3 151 VAL n 
3 152 ASP n 
3 153 ASN n 
3 154 ALA n 
3 155 LEU n 
3 156 GLN n 
3 157 SER n 
3 158 GLY n 
3 159 ASN n 
3 160 SER n 
3 161 GLN n 
3 162 GLU n 
3 163 SER n 
3 164 VAL n 
3 165 THR n 
3 166 GLU n 
3 167 GLN n 
3 168 ASP n 
3 169 SER n 
3 170 LYS n 
3 171 ASP n 
3 172 SER n 
3 173 THR n 
3 174 TYR n 
3 175 SER n 
3 176 LEU n 
3 177 SER n 
3 178 SER n 
3 179 THR n 
3 180 LEU n 
3 181 THR n 
3 182 LEU n 
3 183 SER n 
3 184 LYS n 
3 185 ALA n 
3 186 ASP n 
3 187 TYR n 
3 188 GLU n 
3 189 LYS n 
3 190 HIS n 
3 191 LYS n 
3 192 VAL n 
3 193 TYR n 
3 194 ALA n 
3 195 CYS n 
3 196 GLU n 
3 197 VAL n 
3 198 THR n 
3 199 HIS n 
3 200 GLN n 
3 201 GLY n 
3 202 LEU n 
3 203 SER n 
3 204 SER n 
3 205 PRO n 
3 206 VAL n 
3 207 THR n 
3 208 LYS n 
3 209 SER n 
3 210 PHE n 
3 211 ASN n 
3 212 ARG n 
3 213 GLY n 
3 214 GLU n 
3 215 CYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 125 human ? 'CTLA4, CD152' ? ? ? ? ? ? 'Homo sapiens' 9606 ? Expi293F ? ? ? ? ? human 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? Expi293F ? ? ? ? ? ?       ? ? ? ?    ? ? 
2 1 sample 'Biological sequence' 1 229 human ? ?              ? ? ? ? ? ? 'Homo sapiens' 9606 ? Expi293F ? ? ? ? ? human 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? Expi293F ? ? ? ? ? plasmid ? ? ? pTT5 ? ? 
3 1 sample 'Biological sequence' 1 215 human ? ?              ? ? ? ? ? ? 'Homo sapiens' 9606 ? Expi293F ? ? ? ? ? human 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? Expi293F ? ? ? ? ? ?       ? ? ? ?    ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   ?   ?   ?   C . n 
A 1 2   ALA 2   2   ?   ?   ?   C . n 
A 1 3   MET 3   3   3   MET MET C . n 
A 1 4   HIS 4   4   4   HIS HIS C . n 
A 1 5   VAL 5   5   5   VAL VAL C . n 
A 1 6   ALA 6   6   6   ALA ALA C . n 
A 1 7   GLN 7   7   7   GLN GLN C . n 
A 1 8   PRO 8   8   8   PRO PRO C . n 
A 1 9   ALA 9   9   9   ALA ALA C . n 
A 1 10  VAL 10  10  10  VAL VAL C . n 
A 1 11  VAL 11  11  11  VAL VAL C . n 
A 1 12  LEU 12  12  12  LEU LEU C . n 
A 1 13  ALA 13  13  13  ALA ALA C . n 
A 1 14  SER 14  14  ?   ?   ?   C . n 
A 1 15  SER 15  15  ?   ?   ?   C . n 
A 1 16  ARG 16  16  ?   ?   ?   C . n 
A 1 17  GLY 17  17  17  GLY GLY C . n 
A 1 18  ILE 18  18  18  ILE ILE C . n 
A 1 19  ALA 19  19  19  ALA ALA C . n 
A 1 20  SER 20  20  20  SER SER C . n 
A 1 21  PHE 21  21  21  PHE PHE C . n 
A 1 22  VAL 22  22  22  VAL VAL C . n 
A 1 23  CYS 23  23  23  CYS CYS C . n 
A 1 24  GLU 24  24  24  GLU GLU C . n 
A 1 25  TYR 25  25  25  TYR TYR C . n 
A 1 26  ALA 26  26  26  ALA ALA C . n 
A 1 27  SER 27  27  27  SER SER C . n 
A 1 28  PRO 28  28  28  PRO PRO C . n 
A 1 29  GLY 29  29  ?   ?   ?   C . n 
A 1 30  LYS 30  30  ?   ?   ?   C . n 
A 1 31  ALA 31  31  ?   ?   ?   C . n 
A 1 32  THR 32  32  32  THR THR C . n 
A 1 33  GLU 33  33  33  GLU GLU C . n 
A 1 34  VAL 34  34  34  VAL VAL C . n 
A 1 35  ARG 35  35  35  ARG ARG C . n 
A 1 36  VAL 36  36  36  VAL VAL C . n 
A 1 37  THR 37  37  37  THR THR C . n 
A 1 38  VAL 38  38  38  VAL VAL C . n 
A 1 39  LEU 39  39  39  LEU LEU C . n 
A 1 40  ARG 40  40  40  ARG ARG C . n 
A 1 41  GLN 41  41  41  GLN GLN C . n 
A 1 42  ALA 42  42  42  ALA ALA C . n 
A 1 43  ASP 43  43  43  ASP ASP C . n 
A 1 44  SER 44  44  44  SER SER C . n 
A 1 45  GLN 45  45  45  GLN GLN C . n 
A 1 46  VAL 46  46  46  VAL VAL C . n 
A 1 47  THR 47  47  47  THR THR C . n 
A 1 48  GLU 48  48  48  GLU GLU C . n 
A 1 49  VAL 49  49  49  VAL VAL C . n 
A 1 50  CYS 50  50  50  CYS CYS C . n 
A 1 51  ALA 51  51  51  ALA ALA C . n 
A 1 52  ALA 52  52  52  ALA ALA C . n 
A 1 53  THR 53  53  53  THR THR C . n 
A 1 54  TYR 54  54  54  TYR TYR C . n 
A 1 55  MET 55  55  55  MET MET C . n 
A 1 56  MET 56  56  56  MET MET C . n 
A 1 57  GLY 57  57  ?   ?   ?   C . n 
A 1 58  ASN 58  58  ?   ?   ?   C . n 
A 1 59  GLU 59  59  ?   ?   ?   C . n 
A 1 60  LEU 60  60  ?   ?   ?   C . n 
A 1 61  THR 61  61  ?   ?   ?   C . n 
A 1 62  PHE 62  62  ?   ?   ?   C . n 
A 1 63  LEU 63  63  ?   ?   ?   C . n 
A 1 64  ASP 64  64  ?   ?   ?   C . n 
A 1 65  ASP 65  65  ?   ?   ?   C . n 
A 1 66  SER 66  66  ?   ?   ?   C . n 
A 1 67  ILE 67  67  67  ILE ILE C . n 
A 1 68  CYS 68  68  68  CYS CYS C . n 
A 1 69  THR 69  69  69  THR THR C . n 
A 1 70  GLY 70  70  70  GLY GLY C . n 
A 1 71  THR 71  71  71  THR THR C . n 
A 1 72  SER 72  72  72  SER SER C . n 
A 1 73  SER 73  73  73  SER SER C . n 
A 1 74  GLY 74  74  74  GLY GLY C . n 
A 1 75  ASN 75  75  75  ASN ASN C . n 
A 1 76  GLN 76  76  76  GLN GLN C . n 
A 1 77  VAL 77  77  77  VAL VAL C . n 
A 1 78  ASN 78  78  78  ASN ASN C . n 
A 1 79  LEU 79  79  79  LEU LEU C . n 
A 1 80  THR 80  80  80  THR THR C . n 
A 1 81  ILE 81  81  81  ILE ILE C . n 
A 1 82  GLN 82  82  82  GLN GLN C . n 
A 1 83  GLY 83  83  83  GLY GLY C . n 
A 1 84  LEU 84  84  84  LEU LEU C . n 
A 1 85  ARG 85  85  ?   ?   ?   C . n 
A 1 86  ALA 86  86  ?   ?   ?   C . n 
A 1 87  MET 87  87  ?   ?   ?   C . n 
A 1 88  ASP 88  88  ?   ?   ?   C . n 
A 1 89  THR 89  89  ?   ?   ?   C . n 
A 1 90  GLY 90  90  90  GLY GLY C . n 
A 1 91  LEU 91  91  91  LEU LEU C . n 
A 1 92  TYR 92  92  92  TYR TYR C . n 
A 1 93  ILE 93  93  93  ILE ILE C . n 
A 1 94  CYS 94  94  94  CYS CYS C . n 
A 1 95  LYS 95  95  95  LYS LYS C . n 
A 1 96  VAL 96  96  96  VAL VAL C . n 
A 1 97  GLU 97  97  97  GLU GLU C . n 
A 1 98  LEU 98  98  98  LEU LEU C . n 
A 1 99  MET 99  99  99  MET MET C . n 
A 1 100 TYR 100 100 100 TYR TYR C . n 
A 1 101 PRO 101 101 101 PRO PRO C . n 
A 1 102 PRO 102 102 102 PRO PRO C . n 
A 1 103 PRO 103 103 103 PRO PRO C . n 
A 1 104 TYR 104 104 104 TYR TYR C . n 
A 1 105 TYR 105 105 105 TYR TYR C . n 
A 1 106 LEU 106 106 106 LEU LEU C . n 
A 1 107 GLY 107 107 107 GLY GLY C . n 
A 1 108 ILE 108 108 108 ILE ILE C . n 
A 1 109 GLY 109 109 109 GLY GLY C . n 
A 1 110 ASN 110 110 110 ASN ASN C . n 
A 1 111 GLY 111 111 111 GLY GLY C . n 
A 1 112 THR 112 112 112 THR THR C . n 
A 1 113 GLN 113 113 113 GLN GLN C . n 
A 1 114 ILE 114 114 114 ILE ILE C . n 
A 1 115 TYR 115 115 115 TYR TYR C . n 
A 1 116 VAL 116 116 116 VAL VAL C . n 
A 1 117 ILE 117 117 117 ILE ILE C . n 
A 1 118 ASP 118 118 ?   ?   ?   C . n 
A 1 119 GLY 119 119 ?   ?   ?   C . n 
A 1 120 HIS 120 120 ?   ?   ?   C . n 
A 1 121 HIS 121 121 ?   ?   ?   C . n 
A 1 122 HIS 122 122 ?   ?   ?   C . n 
A 1 123 HIS 123 123 ?   ?   ?   C . n 
A 1 124 HIS 124 124 ?   ?   ?   C . n 
A 1 125 HIS 125 125 ?   ?   ?   C . n 
B 2 1   GLN 1   1   1   GLN GLN H . n 
B 2 2   VAL 2   2   2   VAL VAL H . n 
B 2 3   GLN 3   3   3   GLN GLN H . n 
B 2 4   LEU 4   4   4   LEU LEU H . n 
B 2 5   VAL 5   5   5   VAL VAL H . n 
B 2 6   GLU 6   6   6   GLU GLU H . n 
B 2 7   SER 7   7   7   SER SER H . n 
B 2 8   GLY 8   8   8   GLY GLY H . n 
B 2 9   GLY 9   9   9   GLY GLY H . n 
B 2 10  GLY 10  10  10  GLY GLY H . n 
B 2 11  VAL 11  11  11  VAL VAL H . n 
B 2 12  VAL 12  12  12  VAL VAL H . n 
B 2 13  GLN 13  13  13  GLN GLN H . n 
B 2 14  PRO 14  14  14  PRO PRO H . n 
B 2 15  GLY 15  15  15  GLY GLY H . n 
B 2 16  ARG 16  16  16  ARG ARG H . n 
B 2 17  SER 17  17  17  SER SER H . n 
B 2 18  LEU 18  18  18  LEU LEU H . n 
B 2 19  ARG 19  19  19  ARG ARG H . n 
B 2 20  LEU 20  20  20  LEU LEU H . n 
B 2 21  SER 21  21  21  SER SER H . n 
B 2 22  CYS 22  22  22  CYS CYS H . n 
B 2 23  ALA 23  23  23  ALA ALA H . n 
B 2 24  ALA 24  24  24  ALA ALA H . n 
B 2 25  SER 25  25  25  SER SER H . n 
B 2 26  GLY 26  26  26  GLY GLY H . n 
B 2 27  PHE 27  27  27  PHE PHE H . n 
B 2 28  THR 28  28  28  THR THR H . n 
B 2 29  PHE 29  29  29  PHE PHE H . n 
B 2 30  SER 30  30  30  SER SER H . n 
B 2 31  LYS 31  31  31  LYS LYS H . n 
B 2 32  TYR 32  32  32  TYR TYR H . n 
B 2 33  VAL 33  33  33  VAL VAL H . n 
B 2 34  MET 34  34  34  MET MET H . n 
B 2 35  HIS 35  35  35  HIS HIS H . n 
B 2 36  TRP 36  36  36  TRP TRP H . n 
B 2 37  VAL 37  37  37  VAL VAL H . n 
B 2 38  ARG 38  38  38  ARG ARG H . n 
B 2 39  GLN 39  39  39  GLN GLN H . n 
B 2 40  ALA 40  40  40  ALA ALA H . n 
B 2 41  PRO 41  41  41  PRO PRO H . n 
B 2 42  GLY 42  42  42  GLY GLY H . n 
B 2 43  LYS 43  43  43  LYS LYS H . n 
B 2 44  GLY 44  44  44  GLY GLY H . n 
B 2 45  LEU 45  45  45  LEU LEU H . n 
B 2 46  GLU 46  46  46  GLU GLU H . n 
B 2 47  TRP 47  47  47  TRP TRP H . n 
B 2 48  VAL 48  48  48  VAL VAL H . n 
B 2 49  THR 49  49  49  THR THR H . n 
B 2 50  GLY 50  50  50  GLY GLY H . n 
B 2 51  ILE 51  51  51  ILE ILE H . n 
B 2 52  SER 52  52  52  SER SER H . n 
B 2 53  TYR 53  53  53  TYR TYR H . n 
B 2 54  ASP 54  54  54  ASP ASP H . n 
B 2 55  GLY 55  55  55  GLY GLY H . n 
B 2 56  ARG 56  56  56  ARG ARG H . n 
B 2 57  HIS 57  57  57  HIS HIS H . n 
B 2 58  LYS 58  58  58  LYS LYS H . n 
B 2 59  TYR 59  59  59  TYR TYR H . n 
B 2 60  TYR 60  60  60  TYR TYR H . n 
B 2 61  ALA 61  61  61  ALA ALA H . n 
B 2 62  ASP 62  62  62  ASP ASP H . n 
B 2 63  SER 63  63  63  SER SER H . n 
B 2 64  VAL 64  64  64  VAL VAL H . n 
B 2 65  LYS 65  65  65  LYS LYS H . n 
B 2 66  GLY 66  66  66  GLY GLY H . n 
B 2 67  ARG 67  67  67  ARG ARG H . n 
B 2 68  PHE 68  68  68  PHE PHE H . n 
B 2 69  THR 69  69  69  THR THR H . n 
B 2 70  ILE 70  70  70  ILE ILE H . n 
B 2 71  SER 71  71  71  SER SER H . n 
B 2 72  ARG 72  72  72  ARG ARG H . n 
B 2 73  ASP 73  73  73  ASP ASP H . n 
B 2 74  ASN 74  74  74  ASN ASN H . n 
B 2 75  SER 75  75  75  SER SER H . n 
B 2 76  LYS 76  76  76  LYS LYS H . n 
B 2 77  ASN 77  77  77  ASN ASN H . n 
B 2 78  THR 78  78  78  THR THR H . n 
B 2 79  LEU 79  79  79  LEU LEU H . n 
B 2 80  TYR 80  80  80  TYR TYR H . n 
B 2 81  LEU 81  81  81  LEU LEU H . n 
B 2 82  GLN 82  82  82  GLN GLN H . n 
B 2 83  MET 83  83  83  MET MET H . n 
B 2 84  ASN 84  84  84  ASN ASN H . n 
B 2 85  SER 85  85  85  SER SER H . n 
B 2 86  LEU 86  86  86  LEU LEU H . n 
B 2 87  ARG 87  87  87  ARG ARG H . n 
B 2 88  ALA 88  88  88  ALA ALA H . n 
B 2 89  GLU 89  89  89  GLU GLU H . n 
B 2 90  ASP 90  90  90  ASP ASP H . n 
B 2 91  THR 91  91  91  THR THR H . n 
B 2 92  ALA 92  92  92  ALA ALA H . n 
B 2 93  ILE 93  93  93  ILE ILE H . n 
B 2 94  TYR 94  94  94  TYR TYR H . n 
B 2 95  TYR 95  95  95  TYR TYR H . n 
B 2 96  CYS 96  96  96  CYS CYS H . n 
B 2 97  ALA 97  97  97  ALA ALA H . n 
B 2 98  ARG 98  98  98  ARG ARG H . n 
B 2 99  THR 99  99  99  THR THR H . n 
B 2 100 GLY 100 100 100 GLY GLY H . n 
B 2 101 TRP 101 101 101 TRP TRP H . n 
B 2 102 LEU 102 102 102 LEU LEU H . n 
B 2 103 GLY 103 103 103 GLY GLY H . n 
B 2 104 PRO 104 104 104 PRO PRO H . n 
B 2 105 PHE 105 105 105 PHE PHE H . n 
B 2 106 ASP 106 106 106 ASP ASP H . n 
B 2 107 TYR 107 107 107 TYR TYR H . n 
B 2 108 TRP 108 108 108 TRP TRP H . n 
B 2 109 GLY 109 109 109 GLY GLY H . n 
B 2 110 GLN 110 110 110 GLN GLN H . n 
B 2 111 GLY 111 111 111 GLY GLY H . n 
B 2 112 THR 112 112 112 THR THR H . n 
B 2 113 LEU 113 113 113 LEU LEU H . n 
B 2 114 VAL 114 114 114 VAL VAL H . n 
B 2 115 THR 115 115 115 THR THR H . n 
B 2 116 VAL 116 116 116 VAL VAL H . n 
B 2 117 SER 117 117 117 SER SER H . n 
B 2 118 SER 118 118 118 SER SER H . n 
B 2 119 ALA 119 119 119 ALA ALA H . n 
B 2 120 SER 120 120 120 SER SER H . n 
B 2 121 THR 121 121 121 THR THR H . n 
B 2 122 LYS 122 122 122 LYS LYS H . n 
B 2 123 GLY 123 123 123 GLY GLY H . n 
B 2 124 PRO 124 124 124 PRO PRO H . n 
B 2 125 SER 125 125 125 SER SER H . n 
B 2 126 VAL 126 126 126 VAL VAL H . n 
B 2 127 PHE 127 127 127 PHE PHE H . n 
B 2 128 PRO 128 128 128 PRO PRO H . n 
B 2 129 LEU 129 129 129 LEU LEU H . n 
B 2 130 ALA 130 130 130 ALA ALA H . n 
B 2 131 PRO 131 131 131 PRO PRO H . n 
B 2 132 SER 132 132 ?   ?   ?   H . n 
B 2 133 SER 133 133 ?   ?   ?   H . n 
B 2 134 LYS 134 134 ?   ?   ?   H . n 
B 2 135 SER 135 135 ?   ?   ?   H . n 
B 2 136 THR 136 136 ?   ?   ?   H . n 
B 2 137 SER 137 137 137 SER SER H . n 
B 2 138 GLY 138 138 138 GLY GLY H . n 
B 2 139 GLY 139 139 139 GLY GLY H . n 
B 2 140 THR 140 140 140 THR THR H . n 
B 2 141 ALA 141 141 141 ALA ALA H . n 
B 2 142 ALA 142 142 142 ALA ALA H . n 
B 2 143 LEU 143 143 143 LEU LEU H . n 
B 2 144 GLY 144 144 144 GLY GLY H . n 
B 2 145 CYS 145 145 145 CYS CYS H . n 
B 2 146 LEU 146 146 146 LEU LEU H . n 
B 2 147 VAL 147 147 147 VAL VAL H . n 
B 2 148 LYS 148 148 148 LYS LYS H . n 
B 2 149 ASP 149 149 149 ASP ASP H . n 
B 2 150 TYR 150 150 150 TYR TYR H . n 
B 2 151 PHE 151 151 151 PHE PHE H . n 
B 2 152 PRO 152 152 152 PRO PRO H . n 
B 2 153 GLU 153 153 153 GLU GLU H . n 
B 2 154 PRO 154 154 154 PRO PRO H . n 
B 2 155 VAL 155 155 155 VAL VAL H . n 
B 2 156 THR 156 156 156 THR THR H . n 
B 2 157 VAL 157 157 157 VAL VAL H . n 
B 2 158 SER 158 158 158 SER SER H . n 
B 2 159 TRP 159 159 159 TRP TRP H . n 
B 2 160 ASN 160 160 160 ASN ASN H . n 
B 2 161 SER 161 161 161 SER SER H . n 
B 2 162 GLY 162 162 162 GLY GLY H . n 
B 2 163 ALA 163 163 163 ALA ALA H . n 
B 2 164 LEU 164 164 164 LEU LEU H . n 
B 2 165 THR 165 165 165 THR THR H . n 
B 2 166 SER 166 166 166 SER SER H . n 
B 2 167 GLY 167 167 167 GLY GLY H . n 
B 2 168 VAL 168 168 168 VAL VAL H . n 
B 2 169 HIS 169 169 169 HIS HIS H . n 
B 2 170 THR 170 170 170 THR THR H . n 
B 2 171 PHE 171 171 171 PHE PHE H . n 
B 2 172 PRO 172 172 172 PRO PRO H . n 
B 2 173 ALA 173 173 173 ALA ALA H . n 
B 2 174 VAL 174 174 174 VAL VAL H . n 
B 2 175 LEU 175 175 175 LEU LEU H . n 
B 2 176 GLN 176 176 176 GLN GLN H . n 
B 2 177 SER 177 177 177 SER SER H . n 
B 2 178 SER 178 178 178 SER SER H . n 
B 2 179 GLY 179 179 179 GLY GLY H . n 
B 2 180 LEU 180 180 180 LEU LEU H . n 
B 2 181 TYR 181 181 181 TYR TYR H . n 
B 2 182 SER 182 182 182 SER SER H . n 
B 2 183 LEU 183 183 183 LEU LEU H . n 
B 2 184 SER 184 184 184 SER SER H . n 
B 2 185 SER 185 185 185 SER SER H . n 
B 2 186 VAL 186 186 186 VAL VAL H . n 
B 2 187 VAL 187 187 187 VAL VAL H . n 
B 2 188 THR 188 188 188 THR THR H . n 
B 2 189 VAL 189 189 189 VAL VAL H . n 
B 2 190 PRO 190 190 190 PRO PRO H . n 
B 2 191 SER 191 191 191 SER SER H . n 
B 2 192 SER 192 192 192 SER SER H . n 
B 2 193 SER 193 193 193 SER SER H . n 
B 2 194 LEU 194 194 194 LEU LEU H . n 
B 2 195 GLY 195 195 195 GLY GLY H . n 
B 2 196 THR 196 196 196 THR THR H . n 
B 2 197 GLN 197 197 197 GLN GLN H . n 
B 2 198 THR 198 198 198 THR THR H . n 
B 2 199 TYR 199 199 199 TYR TYR H . n 
B 2 200 ILE 200 200 200 ILE ILE H . n 
B 2 201 CYS 201 201 201 CYS CYS H . n 
B 2 202 ASN 202 202 202 ASN ASN H . n 
B 2 203 VAL 203 203 203 VAL VAL H . n 
B 2 204 ASN 204 204 204 ASN ASN H . n 
B 2 205 HIS 205 205 205 HIS HIS H . n 
B 2 206 LYS 206 206 206 LYS LYS H . n 
B 2 207 PRO 207 207 207 PRO PRO H . n 
B 2 208 SER 208 208 208 SER SER H . n 
B 2 209 ASN 209 209 209 ASN ASN H . n 
B 2 210 THR 210 210 210 THR THR H . n 
B 2 211 LYS 211 211 211 LYS LYS H . n 
B 2 212 VAL 212 212 212 VAL VAL H . n 
B 2 213 ASP 213 213 213 ASP ASP H . n 
B 2 214 LYS 214 214 214 LYS LYS H . n 
B 2 215 ARG 215 215 215 ARG ARG H . n 
B 2 216 VAL 216 216 216 VAL VAL H . n 
B 2 217 GLU 217 217 217 GLU GLU H . n 
B 2 218 PRO 218 218 218 PRO PRO H . n 
B 2 219 LYS 219 219 219 LYS LYS H . n 
B 2 220 SER 220 220 ?   ?   ?   H . n 
B 2 221 CYS 221 221 ?   ?   ?   H . n 
B 2 222 GLY 222 222 ?   ?   ?   H . n 
B 2 223 GLY 223 223 ?   ?   ?   H . n 
B 2 224 HIS 224 224 ?   ?   ?   H . n 
B 2 225 HIS 225 225 ?   ?   ?   H . n 
B 2 226 HIS 226 226 ?   ?   ?   H . n 
B 2 227 HIS 227 227 ?   ?   ?   H . n 
B 2 228 HIS 228 228 ?   ?   ?   H . n 
B 2 229 HIS 229 229 ?   ?   ?   H . n 
C 3 1   GLU 1   1   1   GLU GLU L . n 
C 3 2   ILE 2   2   2   ILE ILE L . n 
C 3 3   VAL 3   3   3   VAL VAL L . n 
C 3 4   LEU 4   4   4   LEU LEU L . n 
C 3 5   THR 5   5   5   THR THR L . n 
C 3 6   GLN 6   6   6   GLN GLN L . n 
C 3 7   SER 7   7   7   SER SER L . n 
C 3 8   PRO 8   8   8   PRO PRO L . n 
C 3 9   GLY 9   9   9   GLY GLY L . n 
C 3 10  THR 10  10  10  THR THR L . n 
C 3 11  LEU 11  11  11  LEU LEU L . n 
C 3 12  SER 12  12  12  SER SER L . n 
C 3 13  LEU 13  13  13  LEU LEU L . n 
C 3 14  SER 14  14  14  SER SER L . n 
C 3 15  PRO 15  15  15  PRO PRO L . n 
C 3 16  GLY 16  16  16  GLY GLY L . n 
C 3 17  GLU 17  17  17  GLU GLU L . n 
C 3 18  ARG 18  18  18  ARG ARG L . n 
C 3 19  ALA 19  19  19  ALA ALA L . n 
C 3 20  THR 20  20  20  THR THR L . n 
C 3 21  LEU 21  21  21  LEU LEU L . n 
C 3 22  SER 22  22  22  SER SER L . n 
C 3 23  CYS 23  23  23  CYS CYS L . n 
C 3 24  ARG 24  24  24  ARG ARG L . n 
C 3 25  GLN 25  25  25  GLN GLN L . n 
C 3 26  SER 26  26  26  SER SER L . n 
C 3 27  GLN 27  27  27  GLN GLN L . n 
C 3 28  SER 28  28  28  SER SER L . n 
C 3 29  VAL 29  29  29  VAL VAL L . n 
C 3 30  GLY 30  30  30  GLY GLY L . n 
C 3 31  TRP 31  31  31  TRP TRP L . n 
C 3 32  SER 32  32  32  SER SER L . n 
C 3 33  PRO 33  33  33  PRO PRO L . n 
C 3 34  LEU 34  34  34  LEU LEU L . n 
C 3 35  ALA 35  35  35  ALA ALA L . n 
C 3 36  TRP 36  36  36  TRP TRP L . n 
C 3 37  TYR 37  37  37  TYR TYR L . n 
C 3 38  GLN 38  38  38  GLN GLN L . n 
C 3 39  GLN 39  39  39  GLN GLN L . n 
C 3 40  LYS 40  40  40  LYS LYS L . n 
C 3 41  PRO 41  41  41  PRO PRO L . n 
C 3 42  GLY 42  42  42  GLY GLY L . n 
C 3 43  GLN 43  43  43  GLN GLN L . n 
C 3 44  ALA 44  44  44  ALA ALA L . n 
C 3 45  PRO 45  45  45  PRO PRO L . n 
C 3 46  ARG 46  46  46  ARG ARG L . n 
C 3 47  LEU 47  47  47  LEU LEU L . n 
C 3 48  LEU 48  48  48  LEU LEU L . n 
C 3 49  ILE 49  49  49  ILE ILE L . n 
C 3 50  TYR 50  50  50  TYR TYR L . n 
C 3 51  GLY 51  51  51  GLY GLY L . n 
C 3 52  ALA 52  52  52  ALA ALA L . n 
C 3 53  PHE 53  53  53  PHE PHE L . n 
C 3 54  SER 54  54  54  SER SER L . n 
C 3 55  ARG 55  55  55  ARG ARG L . n 
C 3 56  ALA 56  56  56  ALA ALA L . n 
C 3 57  THR 57  57  57  THR THR L . n 
C 3 58  GLY 58  58  58  GLY GLY L . n 
C 3 59  ILE 59  59  59  ILE ILE L . n 
C 3 60  PRO 60  60  60  PRO PRO L . n 
C 3 61  ASP 61  61  61  ASP ASP L . n 
C 3 62  ARG 62  62  62  ARG ARG L . n 
C 3 63  PHE 63  63  63  PHE PHE L . n 
C 3 64  SER 64  64  64  SER SER L . n 
C 3 65  GLY 65  65  65  GLY GLY L . n 
C 3 66  SER 66  66  66  SER SER L . n 
C 3 67  GLY 67  67  67  GLY GLY L . n 
C 3 68  SER 68  68  68  SER SER L . n 
C 3 69  GLY 69  69  69  GLY GLY L . n 
C 3 70  THR 70  70  70  THR THR L . n 
C 3 71  ASP 71  71  71  ASP ASP L . n 
C 3 72  PHE 72  72  72  PHE PHE L . n 
C 3 73  THR 73  73  73  THR THR L . n 
C 3 74  LEU 74  74  74  LEU LEU L . n 
C 3 75  THR 75  75  75  THR THR L . n 
C 3 76  ILE 76  76  76  ILE ILE L . n 
C 3 77  SER 77  77  77  SER SER L . n 
C 3 78  ARG 78  78  78  ARG ARG L . n 
C 3 79  LEU 79  79  79  LEU LEU L . n 
C 3 80  GLU 80  80  80  GLU GLU L . n 
C 3 81  PRO 81  81  81  PRO PRO L . n 
C 3 82  GLU 82  82  82  GLU GLU L . n 
C 3 83  ASP 83  83  83  ASP ASP L . n 
C 3 84  PHE 84  84  84  PHE PHE L . n 
C 3 85  ALA 85  85  85  ALA ALA L . n 
C 3 86  VAL 86  86  86  VAL VAL L . n 
C 3 87  TYR 87  87  87  TYR TYR L . n 
C 3 88  TYR 88  88  88  TYR TYR L . n 
C 3 89  CYS 89  89  89  CYS CYS L . n 
C 3 90  GLN 90  90  90  GLN GLN L . n 
C 3 91  GLN 91  91  91  GLN GLN L . n 
C 3 92  TYR 92  92  92  TYR TYR L . n 
C 3 93  GLY 93  93  93  GLY GLY L . n 
C 3 94  GLN 94  94  94  GLN GLN L . n 
C 3 95  SER 95  95  95  SER SER L . n 
C 3 96  PRO 96  96  96  PRO PRO L . n 
C 3 97  TRP 97  97  97  TRP TRP L . n 
C 3 98  THR 98  98  98  THR THR L . n 
C 3 99  PHE 99  99  99  PHE PHE L . n 
C 3 100 GLY 100 100 100 GLY GLY L . n 
C 3 101 GLN 101 101 101 GLN GLN L . n 
C 3 102 GLY 102 102 102 GLY GLY L . n 
C 3 103 THR 103 103 103 THR THR L . n 
C 3 104 LYS 104 104 104 LYS LYS L . n 
C 3 105 VAL 105 105 105 VAL VAL L . n 
C 3 106 GLU 106 106 106 GLU GLU L . n 
C 3 107 ILE 107 107 107 ILE ILE L . n 
C 3 108 LYS 108 108 108 LYS LYS L . n 
C 3 109 ARG 109 109 109 ARG ARG L . n 
C 3 110 THR 110 110 110 THR THR L . n 
C 3 111 VAL 111 111 111 VAL VAL L . n 
C 3 112 ALA 112 112 112 ALA ALA L . n 
C 3 113 ALA 113 113 113 ALA ALA L . n 
C 3 114 PRO 114 114 114 PRO PRO L . n 
C 3 115 SER 115 115 115 SER SER L . n 
C 3 116 VAL 116 116 116 VAL VAL L . n 
C 3 117 PHE 117 117 117 PHE PHE L . n 
C 3 118 ILE 118 118 118 ILE ILE L . n 
C 3 119 PHE 119 119 119 PHE PHE L . n 
C 3 120 PRO 120 120 120 PRO PRO L . n 
C 3 121 PRO 121 121 121 PRO PRO L . n 
C 3 122 SER 122 122 122 SER SER L . n 
C 3 123 ASP 123 123 123 ASP ASP L . n 
C 3 124 GLU 124 124 124 GLU GLU L . n 
C 3 125 GLN 125 125 125 GLN GLN L . n 
C 3 126 LEU 126 126 126 LEU LEU L . n 
C 3 127 LYS 127 127 127 LYS LYS L . n 
C 3 128 SER 128 128 128 SER SER L . n 
C 3 129 GLY 129 129 129 GLY GLY L . n 
C 3 130 THR 130 130 130 THR THR L . n 
C 3 131 ALA 131 131 131 ALA ALA L . n 
C 3 132 SER 132 132 132 SER SER L . n 
C 3 133 VAL 133 133 133 VAL VAL L . n 
C 3 134 VAL 134 134 134 VAL VAL L . n 
C 3 135 CYS 135 135 135 CYS CYS L . n 
C 3 136 LEU 136 136 136 LEU LEU L . n 
C 3 137 LEU 137 137 137 LEU LEU L . n 
C 3 138 ASN 138 138 138 ASN ASN L . n 
C 3 139 ASN 139 139 139 ASN ASN L . n 
C 3 140 PHE 140 140 140 PHE PHE L . n 
C 3 141 TYR 141 141 141 TYR TYR L . n 
C 3 142 PRO 142 142 142 PRO PRO L . n 
C 3 143 ARG 143 143 143 ARG ARG L . n 
C 3 144 GLU 144 144 144 GLU GLU L . n 
C 3 145 ALA 145 145 145 ALA ALA L . n 
C 3 146 LYS 146 146 146 LYS LYS L . n 
C 3 147 VAL 147 147 147 VAL VAL L . n 
C 3 148 GLN 148 148 148 GLN GLN L . n 
C 3 149 TRP 149 149 149 TRP TRP L . n 
C 3 150 LYS 150 150 150 LYS LYS L . n 
C 3 151 VAL 151 151 151 VAL VAL L . n 
C 3 152 ASP 152 152 152 ASP ASP L . n 
C 3 153 ASN 153 153 153 ASN ASN L . n 
C 3 154 ALA 154 154 154 ALA ALA L . n 
C 3 155 LEU 155 155 155 LEU LEU L . n 
C 3 156 GLN 156 156 156 GLN GLN L . n 
C 3 157 SER 157 157 157 SER SER L . n 
C 3 158 GLY 158 158 158 GLY GLY L . n 
C 3 159 ASN 159 159 159 ASN ASN L . n 
C 3 160 SER 160 160 160 SER SER L . n 
C 3 161 GLN 161 161 161 GLN GLN L . n 
C 3 162 GLU 162 162 162 GLU GLU L . n 
C 3 163 SER 163 163 163 SER SER L . n 
C 3 164 VAL 164 164 164 VAL VAL L . n 
C 3 165 THR 165 165 165 THR THR L . n 
C 3 166 GLU 166 166 166 GLU GLU L . n 
C 3 167 GLN 167 167 167 GLN GLN L . n 
C 3 168 ASP 168 168 168 ASP ASP L . n 
C 3 169 SER 169 169 169 SER SER L . n 
C 3 170 LYS 170 170 170 LYS LYS L . n 
C 3 171 ASP 171 171 171 ASP ASP L . n 
C 3 172 SER 172 172 172 SER SER L . n 
C 3 173 THR 173 173 173 THR THR L . n 
C 3 174 TYR 174 174 174 TYR TYR L . n 
C 3 175 SER 175 175 175 SER SER L . n 
C 3 176 LEU 176 176 176 LEU LEU L . n 
C 3 177 SER 177 177 177 SER SER L . n 
C 3 178 SER 178 178 178 SER SER L . n 
C 3 179 THR 179 179 179 THR THR L . n 
C 3 180 LEU 180 180 180 LEU LEU L . n 
C 3 181 THR 181 181 181 THR THR L . n 
C 3 182 LEU 182 182 182 LEU LEU L . n 
C 3 183 SER 183 183 183 SER SER L . n 
C 3 184 LYS 184 184 184 LYS LYS L . n 
C 3 185 ALA 185 185 185 ALA ALA L . n 
C 3 186 ASP 186 186 186 ASP ASP L . n 
C 3 187 TYR 187 187 187 TYR TYR L . n 
C 3 188 GLU 188 188 188 GLU GLU L . n 
C 3 189 LYS 189 189 189 LYS LYS L . n 
C 3 190 HIS 190 190 190 HIS HIS L . n 
C 3 191 LYS 191 191 191 LYS LYS L . n 
C 3 192 VAL 192 192 192 VAL VAL L . n 
C 3 193 TYR 193 193 193 TYR TYR L . n 
C 3 194 ALA 194 194 194 ALA ALA L . n 
C 3 195 CYS 195 195 195 CYS CYS L . n 
C 3 196 GLU 196 196 196 GLU GLU L . n 
C 3 197 VAL 197 197 197 VAL VAL L . n 
C 3 198 THR 198 198 198 THR THR L . n 
C 3 199 HIS 199 199 199 HIS HIS L . n 
C 3 200 GLN 200 200 200 GLN GLN L . n 
C 3 201 GLY 201 201 201 GLY GLY L . n 
C 3 202 LEU 202 202 202 LEU LEU L . n 
C 3 203 SER 203 203 203 SER SER L . n 
C 3 204 SER 204 204 204 SER SER L . n 
C 3 205 PRO 205 205 205 PRO PRO L . n 
C 3 206 VAL 206 206 206 VAL VAL L . n 
C 3 207 THR 207 207 207 THR THR L . n 
C 3 208 LYS 208 208 208 LYS LYS L . n 
C 3 209 SER 209 209 209 SER SER L . n 
C 3 210 PHE 210 210 210 PHE PHE L . n 
C 3 211 ASN 211 211 211 ASN ASN L . n 
C 3 212 ARG 212 212 212 ARG ARG L . n 
C 3 213 GLY 213 213 213 GLY GLY L . n 
C 3 214 GLU 214 214 214 GLU GLU L . n 
C 3 215 CYS 215 215 215 CYS CYS L . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1   201 255 HOH HOH C . 
D 4 HOH 2   202 294 HOH HOH C . 
D 4 HOH 3   203 81  HOH HOH C . 
D 4 HOH 4   204 277 HOH HOH C . 
D 4 HOH 5   205 232 HOH HOH C . 
D 4 HOH 6   206 105 HOH HOH C . 
D 4 HOH 7   207 271 HOH HOH C . 
D 4 HOH 8   208 303 HOH HOH C . 
D 4 HOH 9   209 24  HOH HOH C . 
D 4 HOH 10  210 261 HOH HOH C . 
D 4 HOH 11  211 158 HOH HOH C . 
D 4 HOH 12  212 38  HOH HOH C . 
D 4 HOH 13  213 147 HOH HOH C . 
D 4 HOH 14  214 119 HOH HOH C . 
D 4 HOH 15  215 357 HOH HOH C . 
D 4 HOH 16  216 230 HOH HOH C . 
D 4 HOH 17  217 224 HOH HOH C . 
D 4 HOH 18  218 358 HOH HOH C . 
D 4 HOH 19  219 345 HOH HOH C . 
D 4 HOH 20  220 367 HOH HOH C . 
D 4 HOH 21  221 383 HOH HOH C . 
D 4 HOH 22  222 381 HOH HOH C . 
D 4 HOH 23  223 74  HOH HOH C . 
D 4 HOH 24  224 355 HOH HOH C . 
D 4 HOH 25  225 220 HOH HOH C . 
D 4 HOH 26  226 365 HOH HOH C . 
D 4 HOH 27  227 359 HOH HOH C . 
D 4 HOH 28  228 87  HOH HOH C . 
D 4 HOH 29  229 283 HOH HOH C . 
D 4 HOH 30  230 265 HOH HOH C . 
D 4 HOH 31  231 331 HOH HOH C . 
E 4 HOH 1   301 12  HOH HOH H . 
E 4 HOH 2   302 129 HOH HOH H . 
E 4 HOH 3   303 290 HOH HOH H . 
E 4 HOH 4   304 335 HOH HOH H . 
E 4 HOH 5   305 270 HOH HOH H . 
E 4 HOH 6   306 376 HOH HOH H . 
E 4 HOH 7   307 196 HOH HOH H . 
E 4 HOH 8   308 288 HOH HOH H . 
E 4 HOH 9   309 160 HOH HOH H . 
E 4 HOH 10  310 118 HOH HOH H . 
E 4 HOH 11  311 287 HOH HOH H . 
E 4 HOH 12  312 192 HOH HOH H . 
E 4 HOH 13  313 100 HOH HOH H . 
E 4 HOH 14  314 76  HOH HOH H . 
E 4 HOH 15  315 275 HOH HOH H . 
E 4 HOH 16  316 132 HOH HOH H . 
E 4 HOH 17  317 248 HOH HOH H . 
E 4 HOH 18  318 176 HOH HOH H . 
E 4 HOH 19  319 3   HOH HOH H . 
E 4 HOH 20  320 189 HOH HOH H . 
E 4 HOH 21  321 25  HOH HOH H . 
E 4 HOH 22  322 73  HOH HOH H . 
E 4 HOH 23  323 171 HOH HOH H . 
E 4 HOH 24  324 126 HOH HOH H . 
E 4 HOH 25  325 14  HOH HOH H . 
E 4 HOH 26  326 377 HOH HOH H . 
E 4 HOH 27  327 66  HOH HOH H . 
E 4 HOH 28  328 75  HOH HOH H . 
E 4 HOH 29  329 141 HOH HOH H . 
E 4 HOH 30  330 320 HOH HOH H . 
E 4 HOH 31  331 307 HOH HOH H . 
E 4 HOH 32  332 161 HOH HOH H . 
E 4 HOH 33  333 229 HOH HOH H . 
E 4 HOH 34  334 280 HOH HOH H . 
E 4 HOH 35  335 18  HOH HOH H . 
E 4 HOH 36  336 88  HOH HOH H . 
E 4 HOH 37  337 133 HOH HOH H . 
E 4 HOH 38  338 184 HOH HOH H . 
E 4 HOH 39  339 6   HOH HOH H . 
E 4 HOH 40  340 33  HOH HOH H . 
E 4 HOH 41  341 219 HOH HOH H . 
E 4 HOH 42  342 350 HOH HOH H . 
E 4 HOH 43  343 295 HOH HOH H . 
E 4 HOH 44  344 179 HOH HOH H . 
E 4 HOH 45  345 122 HOH HOH H . 
E 4 HOH 46  346 46  HOH HOH H . 
E 4 HOH 47  347 10  HOH HOH H . 
E 4 HOH 48  348 168 HOH HOH H . 
E 4 HOH 49  349 178 HOH HOH H . 
E 4 HOH 50  350 318 HOH HOH H . 
E 4 HOH 51  351 174 HOH HOH H . 
E 4 HOH 52  352 49  HOH HOH H . 
E 4 HOH 53  353 151 HOH HOH H . 
E 4 HOH 54  354 269 HOH HOH H . 
E 4 HOH 55  355 134 HOH HOH H . 
E 4 HOH 56  356 244 HOH HOH H . 
E 4 HOH 57  357 110 HOH HOH H . 
E 4 HOH 58  358 181 HOH HOH H . 
E 4 HOH 59  359 186 HOH HOH H . 
E 4 HOH 60  360 68  HOH HOH H . 
E 4 HOH 61  361 374 HOH HOH H . 
E 4 HOH 62  362 83  HOH HOH H . 
E 4 HOH 63  363 268 HOH HOH H . 
E 4 HOH 64  364 135 HOH HOH H . 
E 4 HOH 65  365 207 HOH HOH H . 
E 4 HOH 66  366 117 HOH HOH H . 
E 4 HOH 67  367 15  HOH HOH H . 
E 4 HOH 68  368 101 HOH HOH H . 
E 4 HOH 69  369 27  HOH HOH H . 
E 4 HOH 70  370 330 HOH HOH H . 
E 4 HOH 71  371 26  HOH HOH H . 
E 4 HOH 72  372 322 HOH HOH H . 
E 4 HOH 73  373 205 HOH HOH H . 
E 4 HOH 74  374 340 HOH HOH H . 
E 4 HOH 75  375 96  HOH HOH H . 
E 4 HOH 76  376 173 HOH HOH H . 
E 4 HOH 77  377 204 HOH HOH H . 
E 4 HOH 78  378 333 HOH HOH H . 
E 4 HOH 79  379 317 HOH HOH H . 
E 4 HOH 80  380 57  HOH HOH H . 
E 4 HOH 81  381 258 HOH HOH H . 
E 4 HOH 82  382 285 HOH HOH H . 
E 4 HOH 83  383 107 HOH HOH H . 
E 4 HOH 84  384 42  HOH HOH H . 
E 4 HOH 85  385 86  HOH HOH H . 
E 4 HOH 86  386 302 HOH HOH H . 
E 4 HOH 87  387 310 HOH HOH H . 
E 4 HOH 88  388 183 HOH HOH H . 
E 4 HOH 89  389 200 HOH HOH H . 
E 4 HOH 90  390 111 HOH HOH H . 
E 4 HOH 91  391 228 HOH HOH H . 
E 4 HOH 92  392 123 HOH HOH H . 
E 4 HOH 93  393 139 HOH HOH H . 
E 4 HOH 94  394 48  HOH HOH H . 
E 4 HOH 95  395 30  HOH HOH H . 
E 4 HOH 96  396 166 HOH HOH H . 
E 4 HOH 97  397 59  HOH HOH H . 
E 4 HOH 98  398 314 HOH HOH H . 
E 4 HOH 99  399 95  HOH HOH H . 
E 4 HOH 100 400 150 HOH HOH H . 
E 4 HOH 101 401 85  HOH HOH H . 
E 4 HOH 102 402 256 HOH HOH H . 
E 4 HOH 103 403 193 HOH HOH H . 
E 4 HOH 104 404 281 HOH HOH H . 
E 4 HOH 105 405 78  HOH HOH H . 
E 4 HOH 106 406 368 HOH HOH H . 
E 4 HOH 107 407 113 HOH HOH H . 
E 4 HOH 108 408 300 HOH HOH H . 
E 4 HOH 109 409 341 HOH HOH H . 
E 4 HOH 110 410 209 HOH HOH H . 
E 4 HOH 111 411 131 HOH HOH H . 
E 4 HOH 112 412 63  HOH HOH H . 
E 4 HOH 113 413 149 HOH HOH H . 
E 4 HOH 114 414 293 HOH HOH H . 
E 4 HOH 115 415 214 HOH HOH H . 
E 4 HOH 116 416 301 HOH HOH H . 
E 4 HOH 117 417 169 HOH HOH H . 
E 4 HOH 118 418 146 HOH HOH H . 
E 4 HOH 119 419 327 HOH HOH H . 
E 4 HOH 120 420 354 HOH HOH H . 
E 4 HOH 121 421 175 HOH HOH H . 
E 4 HOH 122 422 279 HOH HOH H . 
E 4 HOH 123 423 225 HOH HOH H . 
E 4 HOH 124 424 296 HOH HOH H . 
E 4 HOH 125 425 343 HOH HOH H . 
E 4 HOH 126 426 221 HOH HOH H . 
E 4 HOH 127 427 235 HOH HOH H . 
E 4 HOH 128 428 276 HOH HOH H . 
E 4 HOH 129 429 267 HOH HOH H . 
E 4 HOH 130 430 212 HOH HOH H . 
E 4 HOH 131 431 337 HOH HOH H . 
E 4 HOH 132 432 69  HOH HOH H . 
E 4 HOH 133 433 361 HOH HOH H . 
E 4 HOH 134 434 103 HOH HOH H . 
E 4 HOH 135 435 351 HOH HOH H . 
E 4 HOH 136 436 362 HOH HOH H . 
E 4 HOH 137 437 292 HOH HOH H . 
E 4 HOH 138 438 325 HOH HOH H . 
E 4 HOH 139 439 190 HOH HOH H . 
E 4 HOH 140 440 284 HOH HOH H . 
E 4 HOH 141 441 326 HOH HOH H . 
E 4 HOH 142 442 313 HOH HOH H . 
E 4 HOH 143 443 108 HOH HOH H . 
E 4 HOH 144 444 226 HOH HOH H . 
E 4 HOH 145 445 299 HOH HOH H . 
E 4 HOH 146 446 90  HOH HOH H . 
E 4 HOH 147 447 378 HOH HOH H . 
E 4 HOH 148 448 339 HOH HOH H . 
E 4 HOH 149 449 125 HOH HOH H . 
E 4 HOH 150 450 342 HOH HOH H . 
E 4 HOH 151 451 98  HOH HOH H . 
E 4 HOH 152 452 297 HOH HOH H . 
F 4 HOH 1   301 195 HOH HOH L . 
F 4 HOH 2   302 372 HOH HOH L . 
F 4 HOH 3   303 278 HOH HOH L . 
F 4 HOH 4   304 348 HOH HOH L . 
F 4 HOH 5   305 62  HOH HOH L . 
F 4 HOH 6   306 336 HOH HOH L . 
F 4 HOH 7   307 185 HOH HOH L . 
F 4 HOH 8   308 222 HOH HOH L . 
F 4 HOH 9   309 274 HOH HOH L . 
F 4 HOH 10  310 50  HOH HOH L . 
F 4 HOH 11  311 315 HOH HOH L . 
F 4 HOH 12  312 211 HOH HOH L . 
F 4 HOH 13  313 140 HOH HOH L . 
F 4 HOH 14  314 353 HOH HOH L . 
F 4 HOH 15  315 366 HOH HOH L . 
F 4 HOH 16  316 109 HOH HOH L . 
F 4 HOH 17  317 67  HOH HOH L . 
F 4 HOH 18  318 199 HOH HOH L . 
F 4 HOH 19  319 208 HOH HOH L . 
F 4 HOH 20  320 97  HOH HOH L . 
F 4 HOH 21  321 154 HOH HOH L . 
F 4 HOH 22  322 172 HOH HOH L . 
F 4 HOH 23  323 346 HOH HOH L . 
F 4 HOH 24  324 34  HOH HOH L . 
F 4 HOH 25  325 102 HOH HOH L . 
F 4 HOH 26  326 309 HOH HOH L . 
F 4 HOH 27  327 308 HOH HOH L . 
F 4 HOH 28  328 55  HOH HOH L . 
F 4 HOH 29  329 382 HOH HOH L . 
F 4 HOH 30  330 145 HOH HOH L . 
F 4 HOH 31  331 51  HOH HOH L . 
F 4 HOH 32  332 114 HOH HOH L . 
F 4 HOH 33  333 266 HOH HOH L . 
F 4 HOH 34  334 94  HOH HOH L . 
F 4 HOH 35  335 227 HOH HOH L . 
F 4 HOH 36  336 93  HOH HOH L . 
F 4 HOH 37  337 216 HOH HOH L . 
F 4 HOH 38  338 35  HOH HOH L . 
F 4 HOH 39  339 115 HOH HOH L . 
F 4 HOH 40  340 167 HOH HOH L . 
F 4 HOH 41  341 61  HOH HOH L . 
F 4 HOH 42  342 170 HOH HOH L . 
F 4 HOH 43  343 338 HOH HOH L . 
F 4 HOH 44  344 5   HOH HOH L . 
F 4 HOH 45  345 121 HOH HOH L . 
F 4 HOH 46  346 282 HOH HOH L . 
F 4 HOH 47  347 215 HOH HOH L . 
F 4 HOH 48  348 155 HOH HOH L . 
F 4 HOH 49  349 130 HOH HOH L . 
F 4 HOH 50  350 203 HOH HOH L . 
F 4 HOH 51  351 80  HOH HOH L . 
F 4 HOH 52  352 142 HOH HOH L . 
F 4 HOH 53  353 259 HOH HOH L . 
F 4 HOH 54  354 22  HOH HOH L . 
F 4 HOH 55  355 188 HOH HOH L . 
F 4 HOH 56  356 112 HOH HOH L . 
F 4 HOH 57  357 7   HOH HOH L . 
F 4 HOH 58  358 306 HOH HOH L . 
F 4 HOH 59  359 8   HOH HOH L . 
F 4 HOH 60  360 165 HOH HOH L . 
F 4 HOH 61  361 156 HOH HOH L . 
F 4 HOH 62  362 319 HOH HOH L . 
F 4 HOH 63  363 70  HOH HOH L . 
F 4 HOH 64  364 116 HOH HOH L . 
F 4 HOH 65  365 137 HOH HOH L . 
F 4 HOH 66  366 164 HOH HOH L . 
F 4 HOH 67  367 360 HOH HOH L . 
F 4 HOH 68  368 253 HOH HOH L . 
F 4 HOH 69  369 54  HOH HOH L . 
F 4 HOH 70  370 31  HOH HOH L . 
F 4 HOH 71  371 260 HOH HOH L . 
F 4 HOH 72  372 138 HOH HOH L . 
F 4 HOH 73  373 349 HOH HOH L . 
F 4 HOH 74  374 162 HOH HOH L . 
F 4 HOH 75  375 370 HOH HOH L . 
F 4 HOH 76  376 89  HOH HOH L . 
F 4 HOH 77  377 92  HOH HOH L . 
F 4 HOH 78  378 65  HOH HOH L . 
F 4 HOH 79  379 213 HOH HOH L . 
F 4 HOH 80  380 334 HOH HOH L . 
F 4 HOH 81  381 40  HOH HOH L . 
F 4 HOH 82  382 1   HOH HOH L . 
F 4 HOH 83  383 311 HOH HOH L . 
F 4 HOH 84  384 148 HOH HOH L . 
F 4 HOH 85  385 231 HOH HOH L . 
F 4 HOH 86  386 197 HOH HOH L . 
F 4 HOH 87  387 305 HOH HOH L . 
F 4 HOH 88  388 321 HOH HOH L . 
F 4 HOH 89  389 262 HOH HOH L . 
F 4 HOH 90  390 272 HOH HOH L . 
F 4 HOH 91  391 384 HOH HOH L . 
F 4 HOH 92  392 352 HOH HOH L . 
F 4 HOH 93  393 375 HOH HOH L . 
F 4 HOH 94  394 324 HOH HOH L . 
F 4 HOH 95  395 257 HOH HOH L . 
F 4 HOH 96  396 373 HOH HOH L . 
F 4 HOH 97  397 58  HOH HOH L . 
F 4 HOH 98  398 16  HOH HOH L . 
F 4 HOH 99  399 106 HOH HOH L . 
F 4 HOH 100 400 72  HOH HOH L . 
F 4 HOH 101 401 298 HOH HOH L . 
F 4 HOH 102 402 273 HOH HOH L . 
F 4 HOH 103 403 180 HOH HOH L . 
F 4 HOH 104 404 246 HOH HOH L . 
F 4 HOH 105 405 291 HOH HOH L . 
F 4 HOH 106 406 247 HOH HOH L . 
F 4 HOH 107 407 312 HOH HOH L . 
F 4 HOH 108 408 144 HOH HOH L . 
F 4 HOH 109 409 264 HOH HOH L . 
F 4 HOH 110 410 379 HOH HOH L . 
F 4 HOH 111 411 304 HOH HOH L . 
F 4 HOH 112 412 56  HOH HOH L . 
F 4 HOH 113 413 251 HOH HOH L . 
F 4 HOH 114 414 289 HOH HOH L . 
F 4 HOH 115 415 356 HOH HOH L . 
F 4 HOH 116 416 191 HOH HOH L . 
F 4 HOH 117 417 369 HOH HOH L . 
F 4 HOH 118 418 323 HOH HOH L . 
F 4 HOH 119 419 201 HOH HOH L . 
F 4 HOH 120 420 371 HOH HOH L . 
F 4 HOH 121 421 104 HOH HOH L . 
F 4 HOH 122 422 45  HOH HOH L . 
F 4 HOH 123 423 364 HOH HOH L . 
F 4 HOH 124 424 363 HOH HOH L . 
F 4 HOH 125 425 332 HOH HOH L . 
F 4 HOH 126 426 380 HOH HOH L . 
F 4 HOH 127 427 177 HOH HOH L . 
F 4 HOH 128 428 254 HOH HOH L . 
F 4 HOH 129 429 120 HOH HOH L . 
F 4 HOH 130 430 347 HOH HOH L . 
F 4 HOH 131 431 316 HOH HOH L . 
F 4 HOH 132 432 128 HOH HOH L . 
F 4 HOH 133 433 21  HOH HOH L . 
F 4 HOH 134 434 243 HOH HOH L . 
F 4 HOH 135 435 187 HOH HOH L . 
F 4 HOH 136 436 182 HOH HOH L . 
F 4 HOH 137 437 210 HOH HOH L . 
F 4 HOH 138 438 286 HOH HOH L . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 C LEU 12  ? CG  ? A LEU 12  CG  
2  1 Y 1 C LEU 12  ? CD1 ? A LEU 12  CD1 
3  1 Y 1 C LEU 12  ? CD2 ? A LEU 12  CD2 
4  1 Y 1 C GLU 24  ? CG  ? A GLU 24  CG  
5  1 Y 1 C GLU 24  ? CD  ? A GLU 24  CD  
6  1 Y 1 C GLU 24  ? OE1 ? A GLU 24  OE1 
7  1 Y 1 C GLU 24  ? OE2 ? A GLU 24  OE2 
8  1 Y 1 C SER 44  ? OG  ? A SER 44  OG  
9  1 Y 1 C SER 73  ? OG  ? A SER 73  OG  
10 1 Y 1 C ASN 78  ? CG  ? A ASN 78  CG  
11 1 Y 1 C ASN 78  ? OD1 ? A ASN 78  OD1 
12 1 Y 1 C ASN 78  ? ND2 ? A ASN 78  ND2 
13 1 Y 1 C LEU 79  ? CG  ? A LEU 79  CG  
14 1 Y 1 C LEU 79  ? CD1 ? A LEU 79  CD1 
15 1 Y 1 C LEU 79  ? CD2 ? A LEU 79  CD2 
16 1 Y 1 C VAL 96  ? CG1 ? A VAL 96  CG1 
17 1 Y 1 C VAL 96  ? CG2 ? A VAL 96  CG2 
18 1 Y 1 C ILE 117 ? CG1 ? A ILE 117 CG1 
19 1 Y 1 C ILE 117 ? CG2 ? A ILE 117 CG2 
20 1 Y 1 C ILE 117 ? CD1 ? A ILE 117 CD1 
21 1 Y 1 H LYS 43  ? CD  ? B LYS 43  CD  
22 1 Y 1 H LYS 43  ? CE  ? B LYS 43  CE  
23 1 Y 1 H LYS 43  ? NZ  ? B LYS 43  NZ  
24 1 Y 1 H LYS 65  ? NZ  ? B LYS 65  NZ  
25 1 Y 1 H LYS 76  ? NZ  ? B LYS 76  NZ  
26 1 Y 1 H SER 117 ? OG  ? B SER 117 OG  
27 1 Y 1 H LYS 122 ? CE  ? B LYS 122 CE  
28 1 Y 1 H LYS 122 ? NZ  ? B LYS 122 NZ  
29 1 Y 1 L GLU 124 ? OE1 ? C GLU 124 OE1 
30 1 Y 1 L GLU 124 ? OE2 ? C GLU 124 OE2 
31 1 Y 1 L GLN 148 ? CG  ? C GLN 148 CG  
32 1 Y 1 L GLN 148 ? CD  ? C GLN 148 CD  
33 1 Y 1 L GLN 148 ? OE1 ? C GLN 148 OE1 
34 1 Y 1 L GLN 148 ? NE2 ? C GLN 148 NE2 
35 1 Y 1 L LYS 170 ? CG  ? C LYS 170 CG  
36 1 Y 1 L LYS 170 ? CD  ? C LYS 170 CD  
37 1 Y 1 L LYS 170 ? CE  ? C LYS 170 CE  
38 1 Y 1 L LYS 170 ? NZ  ? C LYS 170 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQ3 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     84.023 
_cell.length_a_esd                 ? 
_cell.length_b                     148.359 
_cell.length_b_esd                 ? 
_cell.length_c                     48.439 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQ3 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQ3 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.44 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.59 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.18 M calcium acetate hydrate, 22.5% w/v PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            300 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 17-ID' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9DQ3 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.636 
_reflns.d_resolution_low                               74.180 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     59236 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           78.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.230 
_reflns.pdbx_Rpim_I_all                                0.093 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       357216 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.210 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.636 
_reflns_shell.d_res_low                                     1.765 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           14724 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2964 
_reflns_shell.percent_possible_obs                          19.4 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.6 
_reflns_shell.pdbx_Rrim_I_all                               0.710 
_reflns_shell.pdbx_Rpim_I_all                               0.308 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.637 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQ3 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.64 
_refine.ls_d_res_low                             41.96 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     59224 
_refine.ls_number_reflns_R_free                  2949 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    78.25 
_refine.ls_percent_reflns_R_free                 4.98 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2336 
_refine.ls_R_factor_R_free                       0.2680 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2318 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 31.09 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.17 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        3953 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.number_atoms_solvent             321 
_refine_hist.number_atoms_total               4274 
_refine_hist.d_res_high                       1.64 
_refine_hist.d_res_low                        41.96 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007  ? ?    ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.931  ? ?    ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 14.848 ? 1427 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.055  ? 621  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007  ? 703  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.64 1.66  . . 10  279  8.00   . . . . 0.3229 . . . . . . . . . . . 0.2809 
'X-RAY DIFFRACTION' 1.66 1.69  . . 28  454  14.00  . . . . 0.2935 . . . . . . . . . . . 0.3831 
'X-RAY DIFFRACTION' 1.69 1.72  . . 37  691  20.00  . . . . 0.2737 . . . . . . . . . . . 0.2823 
'X-RAY DIFFRACTION' 1.72 1.76  . . 48  1004 30.00  . . . . 0.2695 . . . . . . . . . . . 0.4875 
'X-RAY DIFFRACTION' 1.76 1.79  . . 69  1584 46.00  . . . . 0.2719 . . . . . . . . . . . 0.2991 
'X-RAY DIFFRACTION' 1.79 1.83  . . 136 2306 69.00  . . . . 0.2671 . . . . . . . . . . . 0.2869 
'X-RAY DIFFRACTION' 1.83 1.87  . . 137 2650 78.00  . . . . 0.2524 . . . . . . . . . . . 0.2992 
'X-RAY DIFFRACTION' 1.87 1.92  . . 165 2873 85.00  . . . . 0.2459 . . . . . . . . . . . 0.2815 
'X-RAY DIFFRACTION' 1.92 1.97  . . 151 3122 92.00  . . . . 0.2364 . . . . . . . . . . . 0.2739 
'X-RAY DIFFRACTION' 1.97 2.03  . . 179 3282 96.00  . . . . 0.2447 . . . . . . . . . . . 0.2720 
'X-RAY DIFFRACTION' 2.03 2.09  . . 189 3371 100.00 . . . . 0.2413 . . . . . . . . . . . 0.2796 
'X-RAY DIFFRACTION' 2.09 2.17  . . 168 3407 100.00 . . . . 0.2437 . . . . . . . . . . . 0.2676 
'X-RAY DIFFRACTION' 2.17 2.26  . . 165 3416 100.00 . . . . 0.2370 . . . . . . . . . . . 0.2542 
'X-RAY DIFFRACTION' 2.26 2.36  . . 182 3430 100.00 . . . . 0.2550 . . . . . . . . . . . 0.2884 
'X-RAY DIFFRACTION' 2.36 2.48  . . 195 3390 100.00 . . . . 0.2501 . . . . . . . . . . . 0.2591 
'X-RAY DIFFRACTION' 2.48 2.64  . . 171 3439 100.00 . . . . 0.2635 . . . . . . . . . . . 0.2866 
'X-RAY DIFFRACTION' 2.64 2.84  . . 181 3469 100.00 . . . . 0.2585 . . . . . . . . . . . 0.3153 
'X-RAY DIFFRACTION' 2.84 3.13  . . 169 3440 100.00 . . . . 0.2474 . . . . . . . . . . . 0.2934 
'X-RAY DIFFRACTION' 3.13 3.58  . . 198 3454 100.00 . . . . 0.2306 . . . . . . . . . . . 0.2694 
'X-RAY DIFFRACTION' 3.58 4.51  . . 171 3529 100.00 . . . . 0.1921 . . . . . . . . . . . 0.2204 
'X-RAY DIFFRACTION' 4.51 41.96 . . 200 3685 100.00 . . . . 0.1985 . . . . . . . . . . . 0.2424 
# 
_struct.entry_id                     9DQ3 
_struct.title                        'Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQ3 
_struct_keywords.text            'Antibody, CTLA-4, ANTITUMOR PROTEIN-IMMUNE SYSTEM complex' 
_struct_keywords.pdbx_keywords   'ANTITUMOR PROTEIN/IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CTLA4_HUMAN P16410 ? 1 
;KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLT
IQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVID
;
36 
2 PDB 9DQ3        9DQ3   ? 2 ? 1  
3 PDB 9DQ3        9DQ3   ? 3 ? 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQ3 C 1 ? 118 ? P16410 36 ? 153 ? 1 118 
2 2 9DQ3 H 1 ? 229 ? 9DQ3   1  ? 229 ? 1 229 
3 3 9DQ3 L 1 ? 215 ? 9DQ3   1  ? 215 ? 1 215 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQ3 GLY C 119 ? UNP P16410 ? ? 'expression tag' 119 1 
1 9DQ3 HIS C 120 ? UNP P16410 ? ? 'expression tag' 120 2 
1 9DQ3 HIS C 121 ? UNP P16410 ? ? 'expression tag' 121 3 
1 9DQ3 HIS C 122 ? UNP P16410 ? ? 'expression tag' 122 4 
1 9DQ3 HIS C 123 ? UNP P16410 ? ? 'expression tag' 123 5 
1 9DQ3 HIS C 124 ? UNP P16410 ? ? 'expression tag' 124 6 
1 9DQ3 HIS C 125 ? UNP P16410 ? ? 'expression tag' 125 7 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5120  ? 
1 MORE         -34   ? 
1 'SSA (A^2)'  23250 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'gel filtration'            ? 
2 1 'surface plasmon resonance' ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR B 28  ? TYR B 32  ? THR H 28  TYR H 32  5 ? 5 
HELX_P HELX_P2 AA2 ARG B 87  ? THR B 91  ? ARG H 87  THR H 91  5 ? 5 
HELX_P HELX_P3 AA3 SER B 161 ? ALA B 163 ? SER H 161 ALA H 163 5 ? 3 
HELX_P HELX_P4 AA4 SER B 192 ? THR B 196 ? SER H 192 THR H 196 5 ? 5 
HELX_P HELX_P5 AA5 LYS B 206 ? ASN B 209 ? LYS H 206 ASN H 209 5 ? 4 
HELX_P HELX_P6 AA6 GLU C 80  ? PHE C 84  ? GLU L 80  PHE L 84  5 ? 5 
HELX_P HELX_P7 AA7 SER C 122 ? LYS C 127 ? SER L 122 LYS L 127 1 ? 6 
HELX_P HELX_P8 AA8 LYS C 184 ? LYS C 189 ? LYS L 184 LYS L 189 1 ? 6 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 23  SG ? ? ? 1_555 A CYS 94  SG ? ? C CYS 23  C CYS 94  1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2 disulf ? ? A CYS 50  SG ? ? ? 1_555 A CYS 68  SG ? ? C CYS 50  C CYS 68  1_555 ? ? ? ? ? ? ? 2.013 ? ? 
disulf3 disulf ? ? B CYS 22  SG ? ? ? 1_555 B CYS 96  SG ? ? H CYS 22  H CYS 96  1_555 ? ? ? ? ? ? ? 2.023 ? ? 
disulf4 disulf ? ? B CYS 145 SG ? ? ? 1_555 B CYS 201 SG ? ? H CYS 145 H CYS 201 1_555 ? ? ? ? ? ? ? 2.012 ? ? 
disulf5 disulf ? ? C CYS 23  SG ? ? ? 1_555 C CYS 89  SG ? ? L CYS 23  L CYS 89  1_555 ? ? ? ? ? ? ? 2.052 ? ? 
disulf6 disulf ? ? C CYS 135 SG ? ? ? 1_555 C CYS 195 SG ? ? L CYS 135 L CYS 195 1_555 ? ? ? ? ? ? ? 2.001 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 23  ? CYS A 94  ? CYS C 23  ? 1_555 CYS C 94  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 50  ? CYS A 68  ? CYS C 50  ? 1_555 CYS C 68  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 22  ? CYS B 96  ? CYS H 22  ? 1_555 CYS H 96  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 145 ? CYS B 201 ? CYS H 145 ? 1_555 CYS H 201 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS C 23  ? CYS C 89  ? CYS L 23  ? 1_555 CYS L 89  ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS C 135 ? CYS C 195 ? CYS L 135 ? 1_555 CYS L 195 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 100 A . ? TYR 100 C PRO 101 A ? PRO 101 C 1 -0.12 
2 PRO 102 A . ? PRO 102 C PRO 103 A ? PRO 103 C 1 -0.32 
3 PHE 151 B . ? PHE 151 H PRO 152 B ? PRO 152 H 1 -3.16 
4 GLU 153 B . ? GLU 153 H PRO 154 B ? PRO 154 H 1 -0.29 
5 SER 7   C . ? SER 7   L PRO 8   C ? PRO 8   L 1 -6.53 
6 SER 95  C . ? SER 95  L PRO 96  C ? PRO 96  L 1 -4.68 
7 TYR 141 C . ? TYR 141 L PRO 142 C ? PRO 142 L 1 3.77  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 5 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 6 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 3 ? 
AB1 ? 4 ? 
AB2 ? 6 ? 
AB3 ? 4 ? 
AB4 ? 4 ? 
AB5 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? parallel      
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB2 4 5 ? anti-parallel 
AB2 5 6 ? anti-parallel 
AB3 1 2 ? parallel      
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 5   ? ALA A 6   ? VAL C 5   ALA C 6   
AA1 2 ALA A 19  ? TYR A 25  ? ALA C 19  TYR C 25  
AA1 3 GLN A 76  ? ILE A 81  ? GLN C 76  ILE C 81  
AA1 4 CYS A 68  ? SER A 72  ? CYS C 68  SER C 72  
AA2 1 VAL A 10  ? LEU A 12  ? VAL C 10  LEU C 12  
AA2 2 THR A 112 ? TYR A 115 ? THR C 112 TYR C 115 
AA2 3 LEU A 91  ? TYR A 100 ? LEU C 91  TYR C 100 
AA2 4 GLU A 33  ? ALA A 42  ? GLU C 33  ALA C 42  
AA2 5 GLN A 45  ? MET A 55  ? GLN C 45  MET C 55  
AA3 1 VAL A 10  ? LEU A 12  ? VAL C 10  LEU C 12  
AA3 2 THR A 112 ? TYR A 115 ? THR C 112 TYR C 115 
AA3 3 LEU A 91  ? TYR A 100 ? LEU C 91  TYR C 100 
AA3 4 TYR A 105 ? ILE A 108 ? TYR C 105 ILE C 108 
AA4 1 GLN B 3   ? SER B 7   ? GLN H 3   SER H 7   
AA4 2 LEU B 18  ? SER B 25  ? LEU H 18  SER H 25  
AA4 3 THR B 78  ? MET B 83  ? THR H 78  MET H 83  
AA4 4 PHE B 68  ? ASP B 73  ? PHE H 68  ASP H 73  
AA5 1 GLY B 10  ? VAL B 12  ? GLY H 10  VAL H 12  
AA5 2 THR B 112 ? VAL B 116 ? THR H 112 VAL H 116 
AA5 3 ALA B 92  ? THR B 99  ? ALA H 92  THR H 99  
AA5 4 MET B 34  ? GLN B 39  ? MET H 34  GLN H 39  
AA5 5 GLU B 46  ? ILE B 51  ? GLU H 46  ILE H 51  
AA5 6 LYS B 58  ? TYR B 60  ? LYS H 58  TYR H 60  
AA6 1 GLY B 10  ? VAL B 12  ? GLY H 10  VAL H 12  
AA6 2 THR B 112 ? VAL B 116 ? THR H 112 VAL H 116 
AA6 3 ALA B 92  ? THR B 99  ? ALA H 92  THR H 99  
AA6 4 PHE B 105 ? TRP B 108 ? PHE H 105 TRP H 108 
AA7 1 SER B 125 ? LEU B 129 ? SER H 125 LEU H 129 
AA7 2 THR B 140 ? TYR B 150 ? THR H 140 TYR H 150 
AA7 3 TYR B 181 ? PRO B 190 ? TYR H 181 PRO H 190 
AA7 4 VAL B 168 ? THR B 170 ? VAL H 168 THR H 170 
AA8 1 SER B 125 ? LEU B 129 ? SER H 125 LEU H 129 
AA8 2 THR B 140 ? TYR B 150 ? THR H 140 TYR H 150 
AA8 3 TYR B 181 ? PRO B 190 ? TYR H 181 PRO H 190 
AA8 4 VAL B 174 ? LEU B 175 ? VAL H 174 LEU H 175 
AA9 1 THR B 156 ? TRP B 159 ? THR H 156 TRP H 159 
AA9 2 TYR B 199 ? HIS B 205 ? TYR H 199 HIS H 205 
AA9 3 THR B 210 ? VAL B 216 ? THR H 210 VAL H 216 
AB1 1 LEU C 4   ? SER C 7   ? LEU L 4   SER L 7   
AB1 2 ALA C 19  ? GLN C 25  ? ALA L 19  GLN L 25  
AB1 3 ASP C 71  ? ILE C 76  ? ASP L 71  ILE L 76  
AB1 4 PHE C 63  ? SER C 68  ? PHE L 63  SER L 68  
AB2 1 THR C 10  ? LEU C 13  ? THR L 10  LEU L 13  
AB2 2 THR C 103 ? ILE C 107 ? THR L 103 ILE L 107 
AB2 3 VAL C 86  ? GLN C 91  ? VAL L 86  GLN L 91  
AB2 4 LEU C 34  ? GLN C 39  ? LEU L 34  GLN L 39  
AB2 5 ARG C 46  ? TYR C 50  ? ARG L 46  TYR L 50  
AB2 6 SER C 54  ? ARG C 55  ? SER L 54  ARG L 55  
AB3 1 THR C 10  ? LEU C 13  ? THR L 10  LEU L 13  
AB3 2 THR C 103 ? ILE C 107 ? THR L 103 ILE L 107 
AB3 3 VAL C 86  ? GLN C 91  ? VAL L 86  GLN L 91  
AB3 4 THR C 98  ? PHE C 99  ? THR L 98  PHE L 99  
AB4 1 SER C 115 ? PHE C 119 ? SER L 115 PHE L 119 
AB4 2 THR C 130 ? PHE C 140 ? THR L 130 PHE L 140 
AB4 3 TYR C 174 ? SER C 183 ? TYR L 174 SER L 183 
AB4 4 SER C 160 ? VAL C 164 ? SER L 160 VAL L 164 
AB5 1 ALA C 154 ? LEU C 155 ? ALA L 154 LEU L 155 
AB5 2 ALA C 145 ? VAL C 151 ? ALA L 145 VAL L 151 
AB5 3 VAL C 192 ? HIS C 199 ? VAL L 192 HIS L 199 
AB5 4 VAL C 206 ? ASN C 211 ? VAL L 206 ASN L 211 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 6   ? N ALA C 6   O GLU A 24  ? O GLU C 24  
AA1 2 3 N ALA A 19  ? N ALA C 19  O ILE A 81  ? O ILE C 81  
AA1 3 4 O ASN A 78  ? O ASN C 78  N THR A 71  ? N THR C 71  
AA2 1 2 N VAL A 11  ? N VAL C 11  O GLN A 113 ? O GLN C 113 
AA2 2 3 O THR A 112 ? O THR C 112 N TYR A 92  ? N TYR C 92  
AA2 3 4 O ILE A 93  ? O ILE C 93  N LEU A 39  ? N LEU C 39  
AA2 4 5 N VAL A 36  ? N VAL C 36  O ALA A 52  ? O ALA C 52  
AA3 1 2 N VAL A 11  ? N VAL C 11  O GLN A 113 ? O GLN C 113 
AA3 2 3 O THR A 112 ? O THR C 112 N TYR A 92  ? N TYR C 92  
AA3 3 4 N VAL A 96  ? N VAL C 96  O GLY A 107 ? O GLY C 107 
AA4 1 2 N GLN B 3   ? N GLN H 3   O SER B 25  ? O SER H 25  
AA4 2 3 N LEU B 18  ? N LEU H 18  O MET B 83  ? O MET H 83  
AA4 3 4 O GLN B 82  ? O GLN H 82  N THR B 69  ? N THR H 69  
AA5 1 2 N VAL B 12  ? N VAL H 12  O THR B 115 ? O THR H 115 
AA5 2 3 O THR B 112 ? O THR H 112 N TYR B 94  ? N TYR H 94  
AA5 3 4 O TYR B 95  ? O TYR H 95  N VAL B 37  ? N VAL H 37  
AA5 4 5 N ARG B 38  ? N ARG H 38  O GLU B 46  ? O GLU H 46  
AA5 5 6 N GLY B 50  ? N GLY H 50  O TYR B 59  ? O TYR H 59  
AA6 1 2 N VAL B 12  ? N VAL H 12  O THR B 115 ? O THR H 115 
AA6 2 3 O THR B 112 ? O THR H 112 N TYR B 94  ? N TYR H 94  
AA6 3 4 N ARG B 98  ? N ARG H 98  O TYR B 107 ? O TYR H 107 
AA7 1 2 N PHE B 127 ? N PHE H 127 O LEU B 146 ? O LEU H 146 
AA7 2 3 N VAL B 147 ? N VAL H 147 O LEU B 183 ? O LEU H 183 
AA7 3 4 O VAL B 186 ? O VAL H 186 N HIS B 169 ? N HIS H 169 
AA8 1 2 N PHE B 127 ? N PHE H 127 O LEU B 146 ? O LEU H 146 
AA8 2 3 N VAL B 147 ? N VAL H 147 O LEU B 183 ? O LEU H 183 
AA8 3 4 O SER B 182 ? O SER H 182 N VAL B 174 ? N VAL H 174 
AA9 1 2 N SER B 158 ? N SER H 158 O ASN B 202 ? O ASN H 202 
AA9 2 3 N VAL B 203 ? N VAL H 203 O VAL B 212 ? O VAL H 212 
AB1 1 2 N SER C 7   ? N SER L 7   O SER C 22  ? O SER L 22  
AB1 2 3 N LEU C 21  ? N LEU L 21  O LEU C 74  ? O LEU L 74  
AB1 3 4 O THR C 75  ? O THR L 75  N SER C 64  ? N SER L 64  
AB2 1 2 N LEU C 11  ? N LEU L 11  O LYS C 104 ? O LYS L 104 
AB2 2 3 O THR C 103 ? O THR L 103 N TYR C 87  ? N TYR L 87  
AB2 3 4 O TYR C 88  ? O TYR L 88  N TYR C 37  ? N TYR L 37  
AB2 4 5 N TRP C 36  ? N TRP L 36  O LEU C 48  ? O LEU L 48  
AB2 5 6 N TYR C 50  ? N TYR L 50  O SER C 54  ? O SER L 54  
AB3 1 2 N LEU C 11  ? N LEU L 11  O LYS C 104 ? O LYS L 104 
AB3 2 3 O THR C 103 ? O THR L 103 N TYR C 87  ? N TYR L 87  
AB3 3 4 N GLN C 91  ? N GLN L 91  O THR C 98  ? O THR L 98  
AB4 1 2 N PHE C 117 ? N PHE L 117 O LEU C 136 ? O LEU L 136 
AB4 2 3 N VAL C 133 ? N VAL L 133 O LEU C 180 ? O LEU L 180 
AB4 3 4 O THR C 179 ? O THR L 179 N GLN C 161 ? N GLN L 161 
AB5 1 2 O ALA C 154 ? O ALA L 154 N VAL C 151 ? N VAL L 151 
AB5 2 3 N LYS C 150 ? N LYS L 150 O ALA C 194 ? O ALA L 194 
AB5 3 4 N CYS C 195 ? N CYS L 195 O LYS C 208 ? O LYS L 208 
# 
_pdbx_entry_details.entry_id                   9DQ3 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O H ASN 77  ? ? O H HOH 301 ? ? 1.88 
2  1 O H HOH 394 ? ? O H HOH 402 ? ? 2.03 
3  1 O L HOH 415 ? ? O L HOH 418 ? ? 2.07 
4  1 O H HOH 444 ? ? O L HOH 429 ? ? 2.09 
5  1 N H ALA 24  ? ? O H HOH 301 ? ? 2.10 
6  1 O H HOH 329 ? ? O H HOH 447 ? ? 2.10 
7  1 N L GLU 1   ? ? O L HOH 301 ? ? 2.11 
8  1 O C HOH 220 ? ? O C HOH 222 ? ? 2.13 
9  1 O C HOH 225 ? ? O C HOH 228 ? ? 2.16 
10 1 O C HOH 221 ? ? O C HOH 223 ? ? 2.16 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    NH1 
_pdbx_validate_symm_contact.auth_asym_id_1    H 
_pdbx_validate_symm_contact.auth_comp_id_1    ARG 
_pdbx_validate_symm_contact.auth_seq_id_1     215 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    H 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     301 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_456 
_pdbx_validate_symm_contact.dist              1.97 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP C 43  ? ? 55.68  -116.93 
2 1 ASN C 75  ? ? -90.98 46.97   
3 1 ASP H 149 ? ? 70.20  65.95   
4 1 SER H 166 ? ? 157.38 109.80  
5 1 ALA L 52  ? ? 68.18  -40.48  
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      H 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       452 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.33 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 C LYS 1   ? A LYS 1   
2  1 Y 1 C ALA 2   ? A ALA 2   
3  1 Y 1 C SER 14  ? A SER 14  
4  1 Y 1 C SER 15  ? A SER 15  
5  1 Y 1 C ARG 16  ? A ARG 16  
6  1 Y 1 C GLY 29  ? A GLY 29  
7  1 Y 1 C LYS 30  ? A LYS 30  
8  1 Y 1 C ALA 31  ? A ALA 31  
9  1 Y 1 C GLY 57  ? A GLY 57  
10 1 Y 1 C ASN 58  ? A ASN 58  
11 1 Y 1 C GLU 59  ? A GLU 59  
12 1 Y 1 C LEU 60  ? A LEU 60  
13 1 Y 1 C THR 61  ? A THR 61  
14 1 Y 1 C PHE 62  ? A PHE 62  
15 1 Y 1 C LEU 63  ? A LEU 63  
16 1 Y 1 C ASP 64  ? A ASP 64  
17 1 Y 1 C ASP 65  ? A ASP 65  
18 1 Y 1 C SER 66  ? A SER 66  
19 1 Y 1 C ARG 85  ? A ARG 85  
20 1 Y 1 C ALA 86  ? A ALA 86  
21 1 Y 1 C MET 87  ? A MET 87  
22 1 Y 1 C ASP 88  ? A ASP 88  
23 1 Y 1 C THR 89  ? A THR 89  
24 1 Y 1 C ASP 118 ? A ASP 118 
25 1 Y 1 C GLY 119 ? A GLY 119 
26 1 Y 1 C HIS 120 ? A HIS 120 
27 1 Y 1 C HIS 121 ? A HIS 121 
28 1 Y 1 C HIS 122 ? A HIS 122 
29 1 Y 1 C HIS 123 ? A HIS 123 
30 1 Y 1 C HIS 124 ? A HIS 124 
31 1 Y 1 C HIS 125 ? A HIS 125 
32 1 Y 1 H SER 132 ? B SER 132 
33 1 Y 1 H SER 133 ? B SER 133 
34 1 Y 1 H LYS 134 ? B LYS 134 
35 1 Y 1 H SER 135 ? B SER 135 
36 1 Y 1 H THR 136 ? B THR 136 
37 1 Y 1 H SER 220 ? B SER 220 
38 1 Y 1 H CYS 221 ? B CYS 221 
39 1 Y 1 H GLY 222 ? B GLY 222 
40 1 Y 1 H GLY 223 ? B GLY 223 
41 1 Y 1 H HIS 224 ? B HIS 224 
42 1 Y 1 H HIS 225 ? B HIS 225 
43 1 Y 1 H HIS 226 ? B HIS 226 
44 1 Y 1 H HIS 227 ? B HIS 227 
45 1 Y 1 H HIS 228 ? B HIS 228 
46 1 Y 1 H HIS 229 ? B HIS 229 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9DQ3 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011902 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006740 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.020645 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . MET A 1 3   ? 16.715  12.070 -12.449 1.00 31.27 ? 3   MET C N   1 
ATOM   2    C CA  . MET A 1 3   ? 17.668  11.650 -13.467 1.00 30.55 ? 3   MET C CA  1 
ATOM   3    C C   . MET A 1 3   ? 18.830  10.899 -12.840 1.00 30.95 ? 3   MET C C   1 
ATOM   4    O O   . MET A 1 3   ? 19.474  11.376 -11.909 1.00 32.40 ? 3   MET C O   1 
ATOM   5    C CB  . MET A 1 3   ? 18.181  12.851 -14.263 1.00 28.61 ? 3   MET C CB  1 
ATOM   6    C CG  . MET A 1 3   ? 18.829  13.932 -13.419 1.00 28.87 ? 3   MET C CG  1 
ATOM   7    S SD  . MET A 1 3   ? 20.163  14.753 -14.304 1.00 42.57 ? 3   MET C SD  1 
ATOM   8    C CE  . MET A 1 3   ? 19.622  14.514 -15.978 1.00 30.37 ? 3   MET C CE  1 
ATOM   9    N N   . HIS A 1 4   ? 19.077  9.705  -13.360 1.00 30.00 ? 4   HIS C N   1 
ATOM   10   C CA  . HIS A 1 4   ? 20.150  8.861  -12.870 1.00 27.30 ? 4   HIS C CA  1 
ATOM   11   C C   . HIS A 1 4   ? 21.484  9.310  -13.465 1.00 30.02 ? 4   HIS C C   1 
ATOM   12   O O   . HIS A 1 4   ? 21.569  9.664  -14.644 1.00 30.61 ? 4   HIS C O   1 
ATOM   13   C CB  . HIS A 1 4   ? 19.837  7.404  -13.222 1.00 29.60 ? 4   HIS C CB  1 
ATOM   14   C CG  . HIS A 1 4   ? 21.021  6.495  -13.189 1.00 31.40 ? 4   HIS C CG  1 
ATOM   15   N ND1 . HIS A 1 4   ? 21.552  6.001  -12.017 1.00 34.90 ? 4   HIS C ND1 1 
ATOM   16   C CD2 . HIS A 1 4   ? 21.775  5.983  -14.189 1.00 32.81 ? 4   HIS C CD2 1 
ATOM   17   C CE1 . HIS A 1 4   ? 22.584  5.223  -12.296 1.00 34.08 ? 4   HIS C CE1 1 
ATOM   18   N NE2 . HIS A 1 4   ? 22.743  5.199  -13.607 1.00 35.06 ? 4   HIS C NE2 1 
ATOM   19   N N   . VAL A 1 5   ? 22.519  9.335  -12.629 1.00 27.98 ? 5   VAL C N   1 
ATOM   20   C CA  . VAL A 1 5   ? 23.876  9.684  -13.043 1.00 28.23 ? 5   VAL C CA  1 
ATOM   21   C C   . VAL A 1 5   ? 24.770  8.485  -12.764 1.00 30.68 ? 5   VAL C C   1 
ATOM   22   O O   . VAL A 1 5   ? 24.865  8.024  -11.619 1.00 29.00 ? 5   VAL C O   1 
ATOM   23   C CB  . VAL A 1 5   ? 24.399  10.933 -12.315 1.00 26.64 ? 5   VAL C CB  1 
ATOM   24   C CG1 . VAL A 1 5   ? 25.923  10.989 -12.377 1.00 29.38 ? 5   VAL C CG1 1 
ATOM   25   C CG2 . VAL A 1 5   ? 23.806  12.190 -12.924 1.00 26.51 ? 5   VAL C CG2 1 
ATOM   26   N N   . ALA A 1 6   ? 25.430  7.987  -13.805 1.00 30.54 ? 6   ALA C N   1 
ATOM   27   C CA  . ALA A 1 6   ? 26.308  6.829  -13.712 1.00 30.36 ? 6   ALA C CA  1 
ATOM   28   C C   . ALA A 1 6   ? 27.760  7.278  -13.762 1.00 29.68 ? 6   ALA C C   1 
ATOM   29   O O   . ALA A 1 6   ? 28.124  8.114  -14.596 1.00 32.16 ? 6   ALA C O   1 
ATOM   30   C CB  . ALA A 1 6   ? 26.030  5.846  -14.851 1.00 32.69 ? 6   ALA C CB  1 
ATOM   31   N N   . GLN A 1 7   ? 28.580  6.731  -12.869 1.00 27.89 ? 7   GLN C N   1 
ATOM   32   C CA  . GLN A 1 7   ? 30.014  6.956  -12.918 1.00 31.29 ? 7   GLN C CA  1 
ATOM   33   C C   . GLN A 1 7   ? 30.717  5.683  -12.471 1.00 34.62 ? 7   GLN C C   1 
ATOM   34   O O   . GLN A 1 7   ? 30.120  4.874  -11.748 1.00 32.88 ? 7   GLN C O   1 
ATOM   35   C CB  . GLN A 1 7   ? 30.434  8.142  -12.039 1.00 31.76 ? 7   GLN C CB  1 
ATOM   36   C CG  . GLN A 1 7   ? 29.966  8.070  -10.600 1.00 28.97 ? 7   GLN C CG  1 
ATOM   37   C CD  . GLN A 1 7   ? 30.404  9.281  -9.789  1.00 31.01 ? 7   GLN C CD  1 
ATOM   38   O OE1 . GLN A 1 7   ? 29.603  9.893  -9.072  1.00 26.97 ? 7   GLN C OE1 1 
ATOM   39   N NE2 . GLN A 1 7   ? 31.681  9.631  -9.895  1.00 31.39 ? 7   GLN C NE2 1 
ATOM   40   N N   . PRO A 1 8   ? 31.970  5.470  -12.891 1.00 36.96 ? 8   PRO C N   1 
ATOM   41   C CA  . PRO A 1 8   ? 32.706  4.274  -12.458 1.00 33.93 ? 8   PRO C CA  1 
ATOM   42   C C   . PRO A 1 8   ? 32.821  4.196  -10.945 1.00 32.83 ? 8   PRO C C   1 
ATOM   43   O O   . PRO A 1 8   ? 33.037  5.201  -10.265 1.00 36.27 ? 8   PRO C O   1 
ATOM   44   C CB  . PRO A 1 8   ? 34.081  4.449  -13.114 1.00 34.09 ? 8   PRO C CB  1 
ATOM   45   C CG  . PRO A 1 8   ? 33.824  5.303  -14.302 1.00 35.76 ? 8   PRO C CG  1 
ATOM   46   C CD  . PRO A 1 8   ? 32.719  6.242  -13.898 1.00 33.91 ? 8   PRO C CD  1 
ATOM   47   N N   . ALA A 1 9   ? 32.676  2.982  -10.415 1.00 33.85 ? 9   ALA C N   1 
ATOM   48   C CA  . ALA A 1 9   ? 32.809  2.774  -8.980  1.00 35.61 ? 9   ALA C CA  1 
ATOM   49   C C   . ALA A 1 9   ? 34.256  2.852  -8.506  1.00 38.03 ? 9   ALA C C   1 
ATOM   50   O O   . ALA A 1 9   ? 34.494  3.184  -7.337  1.00 35.24 ? 9   ALA C O   1 
ATOM   51   C CB  . ALA A 1 9   ? 32.211  1.421  -8.592  1.00 37.96 ? 9   ALA C CB  1 
ATOM   52   N N   . VAL A 1 10  ? 35.218  2.566  -9.384  1.00 38.67 ? 10  VAL C N   1 
ATOM   53   C CA  . VAL A 1 10  ? 36.631  2.522  -9.025  1.00 36.93 ? 10  VAL C CA  1 
ATOM   54   C C   . VAL A 1 10  ? 37.459  2.958  -10.222 1.00 32.98 ? 10  VAL C C   1 
ATOM   55   O O   . VAL A 1 10  ? 37.197  2.554  -11.358 1.00 32.50 ? 10  VAL C O   1 
ATOM   56   C CB  . VAL A 1 10  ? 37.057  1.112  -8.575  1.00 39.32 ? 10  VAL C CB  1 
ATOM   57   C CG1 . VAL A 1 10  ? 36.740  0.902  -7.103  1.00 39.42 ? 10  VAL C CG1 1 
ATOM   58   C CG2 . VAL A 1 10  ? 36.365  0.076  -9.444  1.00 39.79 ? 10  VAL C CG2 1 
ATOM   59   N N   . VAL A 1 11  ? 38.478  3.769  -9.954  1.00 36.88 ? 11  VAL C N   1 
ATOM   60   C CA  . VAL A 1 11  ? 39.421  4.226  -10.967 1.00 36.59 ? 11  VAL C CA  1 
ATOM   61   C C   . VAL A 1 11  ? 40.797  4.278  -10.317 1.00 37.52 ? 11  VAL C C   1 
ATOM   62   O O   . VAL A 1 11  ? 40.927  4.540  -9.117  1.00 37.41 ? 11  VAL C O   1 
ATOM   63   C CB  . VAL A 1 11  ? 38.999  5.599  -11.555 1.00 36.96 ? 11  VAL C CB  1 
ATOM   64   C CG1 . VAL A 1 11  ? 40.198  6.467  -11.894 1.00 39.00 ? 11  VAL C CG1 1 
ATOM   65   C CG2 . VAL A 1 11  ? 38.122  5.401  -12.781 1.00 37.17 ? 11  VAL C CG2 1 
ATOM   66   N N   . LEU A 1 12  ? 41.828  3.977  -11.100 1.00 40.83 ? 12  LEU C N   1 
ATOM   67   C CA  . LEU A 1 12  ? 43.201  4.062  -10.628 1.00 39.23 ? 12  LEU C CA  1 
ATOM   68   C C   . LEU A 1 12  ? 43.899  5.225  -11.320 1.00 39.51 ? 12  LEU C C   1 
ATOM   69   O O   . LEU A 1 12  ? 43.712  5.448  -12.520 1.00 36.79 ? 12  LEU C O   1 
ATOM   70   C CB  . LEU A 1 12  ? 43.955  2.749  -10.880 1.00 40.49 ? 12  LEU C CB  1 
ATOM   71   N N   . ALA A 1 13  ? 44.685  5.975  -10.558 1.00 40.27 ? 13  ALA C N   1 
ATOM   72   C CA  . ALA A 1 13  ? 45.431  7.092  -11.125 1.00 42.75 ? 13  ALA C CA  1 
ATOM   73   C C   . ALA A 1 13  ? 46.801  6.639  -11.646 1.00 43.08 ? 13  ALA C C   1 
ATOM   74   O O   . ALA A 1 13  ? 47.435  7.322  -12.461 1.00 50.48 ? 13  ALA C O   1 
ATOM   75   C CB  . ALA A 1 13  ? 45.589  8.197  -10.094 1.00 43.67 ? 13  ALA C CB  1 
ATOM   76   N N   . GLY A 1 17  ? 49.248  10.831 -10.896 1.00 50.84 ? 17  GLY C N   1 
ATOM   77   C CA  . GLY A 1 17  ? 48.588  11.944 -10.235 1.00 50.27 ? 17  GLY C CA  1 
ATOM   78   C C   . GLY A 1 17  ? 47.320  12.398 -10.937 1.00 47.15 ? 17  GLY C C   1 
ATOM   79   O O   . GLY A 1 17  ? 46.563  13.215 -10.412 1.00 48.42 ? 17  GLY C O   1 
ATOM   80   N N   . ILE A 1 18  ? 47.088  11.864 -12.132 1.00 47.07 ? 18  ILE C N   1 
ATOM   81   C CA  . ILE A 1 18  ? 45.900  12.165 -12.920 1.00 45.74 ? 18  ILE C CA  1 
ATOM   82   C C   . ILE A 1 18  ? 44.956  10.973 -12.866 1.00 44.96 ? 18  ILE C C   1 
ATOM   83   O O   . ILE A 1 18  ? 45.392  9.817  -12.875 1.00 44.89 ? 18  ILE C O   1 
ATOM   84   C CB  . ILE A 1 18  ? 46.254  12.516 -14.378 1.00 45.64 ? 18  ILE C CB  1 
ATOM   85   C CG1 . ILE A 1 18  ? 47.205  11.470 -14.978 1.00 50.30 ? 18  ILE C CG1 1 
ATOM   86   C CG2 . ILE A 1 18  ? 46.850  13.914 -14.458 1.00 47.57 ? 18  ILE C CG2 1 
ATOM   87   C CD1 . ILE A 1 18  ? 46.515  10.349 -15.758 1.00 48.23 ? 18  ILE C CD1 1 
ATOM   88   N N   . ALA A 1 19  ? 43.662  11.262 -12.799 1.00 42.13 ? 19  ALA C N   1 
ATOM   89   C CA  . ALA A 1 19  ? 42.619  10.254 -12.884 1.00 38.08 ? 19  ALA C CA  1 
ATOM   90   C C   . ALA A 1 19  ? 41.492  10.841 -13.710 1.00 38.83 ? 19  ALA C C   1 
ATOM   91   O O   . ALA A 1 19  ? 41.131  12.007 -13.521 1.00 40.15 ? 19  ALA C O   1 
ATOM   92   C CB  . ALA A 1 19  ? 42.112  9.842  -11.497 1.00 39.12 ? 19  ALA C CB  1 
ATOM   93   N N   . SER A 1 20  ? 40.962  10.051 -14.642 1.00 36.38 ? 20  SER C N   1 
ATOM   94   C CA  . SER A 1 20  ? 39.877  10.481 -15.511 1.00 39.37 ? 20  SER C CA  1 
ATOM   95   C C   . SER A 1 20  ? 38.721  9.495  -15.417 1.00 42.28 ? 20  SER C C   1 
ATOM   96   O O   . SER A 1 20  ? 38.937  8.282  -15.342 1.00 44.77 ? 20  SER C O   1 
ATOM   97   C CB  . SER A 1 20  ? 40.344  10.605 -16.965 1.00 39.61 ? 20  SER C CB  1 
ATOM   98   O OG  . SER A 1 20  ? 40.830  9.365  -17.451 1.00 48.89 ? 20  SER C OG  1 
ATOM   99   N N   . PHE A 1 21  ? 37.492  10.010 -15.409 1.00 39.23 ? 21  PHE C N   1 
ATOM   100  C CA  . PHE A 1 21  ? 36.338  9.123  -15.389 1.00 38.12 ? 21  PHE C CA  1 
ATOM   101  C C   . PHE A 1 21  ? 35.174  9.775  -16.117 1.00 38.09 ? 21  PHE C C   1 
ATOM   102  O O   . PHE A 1 21  ? 35.048  11.003 -16.152 1.00 40.06 ? 21  PHE C O   1 
ATOM   103  C CB  . PHE A 1 21  ? 35.932  8.731  -13.957 1.00 39.63 ? 21  PHE C CB  1 
ATOM   104  C CG  . PHE A 1 21  ? 35.394  9.867  -13.129 1.00 39.42 ? 21  PHE C CG  1 
ATOM   105  C CD1 . PHE A 1 21  ? 34.037  10.164 -13.127 1.00 36.38 ? 21  PHE C CD1 1 
ATOM   106  C CD2 . PHE A 1 21  ? 36.240  10.620 -12.328 1.00 38.96 ? 21  PHE C CD2 1 
ATOM   107  C CE1 . PHE A 1 21  ? 33.540  11.205 -12.360 1.00 35.45 ? 21  PHE C CE1 1 
ATOM   108  C CE2 . PHE A 1 21  ? 35.745  11.665 -11.557 1.00 38.14 ? 21  PHE C CE2 1 
ATOM   109  C CZ  . PHE A 1 21  ? 34.395  11.953 -11.572 1.00 32.87 ? 21  PHE C CZ  1 
ATOM   110  N N   . VAL A 1 22  ? 34.332  8.938  -16.697 1.00 37.13 ? 22  VAL C N   1 
ATOM   111  C CA  . VAL A 1 22  ? 33.177  9.393  -17.457 1.00 34.80 ? 22  VAL C CA  1 
ATOM   112  C C   . VAL A 1 22  ? 31.963  9.440  -16.546 1.00 38.65 ? 22  VAL C C   1 
ATOM   113  O O   . VAL A 1 22  ? 31.746  8.560  -15.710 1.00 36.29 ? 22  VAL C O   1 
ATOM   114  C CB  . VAL A 1 22  ? 32.933  8.489  -18.677 1.00 39.14 ? 22  VAL C CB  1 
ATOM   115  C CG1 . VAL A 1 22  ? 31.457  8.470  -19.054 1.00 40.44 ? 22  VAL C CG1 1 
ATOM   116  C CG2 . VAL A 1 22  ? 33.774  8.971  -19.856 1.00 39.84 ? 22  VAL C CG2 1 
ATOM   117  N N   . CYS A 1 23  ? 31.167  10.487 -16.710 1.00 39.37 ? 23  CYS C N   1 
ATOM   118  C CA  . CYS A 1 23  ? 29.984  10.714 -15.900 1.00 38.60 ? 23  CYS C CA  1 
ATOM   119  C C   . CYS A 1 23  ? 28.815  10.892 -16.858 1.00 37.25 ? 23  CYS C C   1 
ATOM   120  O O   . CYS A 1 23  ? 28.826  11.811 -17.684 1.00 40.15 ? 23  CYS C O   1 
ATOM   121  C CB  . CYS A 1 23  ? 30.206  11.936 -15.005 1.00 38.27 ? 23  CYS C CB  1 
ATOM   122  S SG  . CYS A 1 23  ? 28.886  12.340 -13.915 1.00 52.98 ? 23  CYS C SG  1 
ATOM   123  N N   . GLU A 1 24  ? 27.836  9.990  -16.785 1.00 33.75 ? 24  GLU C N   1 
ATOM   124  C CA  . GLU A 1 24  ? 26.768  9.914  -17.775 1.00 33.67 ? 24  GLU C CA  1 
ATOM   125  C C   . GLU A 1 24  ? 25.407  10.114 -17.119 1.00 33.87 ? 24  GLU C C   1 
ATOM   126  O O   . GLU A 1 24  ? 25.139  9.569  -16.046 1.00 34.47 ? 24  GLU C O   1 
ATOM   127  C CB  . GLU A 1 24  ? 26.798  8.567  -18.510 1.00 34.20 ? 24  GLU C CB  1 
ATOM   128  N N   . TYR A 1 25  ? 24.539  10.874 -17.786 1.00 35.32 ? 25  TYR C N   1 
ATOM   129  C CA  . TYR A 1 25  ? 23.217  11.191 -17.262 1.00 37.28 ? 25  TYR C CA  1 
ATOM   130  C C   . TYR A 1 25  ? 22.176  11.041 -18.361 1.00 38.28 ? 25  TYR C C   1 
ATOM   131  O O   . TYR A 1 25  ? 22.492  11.069 -19.553 1.00 42.89 ? 25  TYR C O   1 
ATOM   132  C CB  . TYR A 1 25  ? 23.170  12.610 -16.675 1.00 34.95 ? 25  TYR C CB  1 
ATOM   133  C CG  . TYR A 1 25  ? 23.534  13.721 -17.643 1.00 35.02 ? 25  TYR C CG  1 
ATOM   134  C CD1 . TYR A 1 25  ? 24.852  13.928 -18.035 1.00 36.86 ? 25  TYR C CD1 1 
ATOM   135  C CD2 . TYR A 1 25  ? 22.565  14.577 -18.137 1.00 36.79 ? 25  TYR C CD2 1 
ATOM   136  C CE1 . TYR A 1 25  ? 25.188  14.946 -18.907 1.00 37.43 ? 25  TYR C CE1 1 
ATOM   137  C CE2 . TYR A 1 25  ? 22.889  15.599 -19.011 1.00 37.39 ? 25  TYR C CE2 1 
ATOM   138  C CZ  . TYR A 1 25  ? 24.202  15.781 -19.394 1.00 38.75 ? 25  TYR C CZ  1 
ATOM   139  O OH  . TYR A 1 25  ? 24.535  16.800 -20.261 1.00 40.69 ? 25  TYR C OH  1 
ATOM   140  N N   . ALA A 1 26  ? 20.919  10.902 -17.945 1.00 40.81 ? 26  ALA C N   1 
ATOM   141  C CA  . ALA A 1 26  ? 19.788  10.739 -18.859 1.00 43.58 ? 26  ALA C CA  1 
ATOM   142  C C   . ALA A 1 26  ? 18.956  12.022 -18.847 1.00 43.81 ? 26  ALA C C   1 
ATOM   143  O O   . ALA A 1 26  ? 17.971  12.143 -18.116 1.00 46.75 ? 26  ALA C O   1 
ATOM   144  C CB  . ALA A 1 26  ? 18.955  9.530  -18.461 1.00 39.37 ? 26  ALA C CB  1 
ATOM   145  N N   . SER A 1 27  ? 19.356  12.986 -19.670 1.00 43.37 ? 27  SER C N   1 
ATOM   146  C CA  . SER A 1 27  ? 18.652  14.268 -19.702 1.00 43.42 ? 27  SER C CA  1 
ATOM   147  C C   . SER A 1 27  ? 17.319  14.123 -20.430 1.00 49.65 ? 27  SER C C   1 
ATOM   148  O O   . SER A 1 27  ? 17.282  13.571 -21.536 1.00 48.96 ? 27  SER C O   1 
ATOM   149  C CB  . SER A 1 27  ? 19.511  15.336 -20.384 1.00 45.33 ? 27  SER C CB  1 
ATOM   150  O OG  . SER A 1 27  ? 18.740  16.160 -21.260 1.00 46.30 ? 27  SER C OG  1 
ATOM   151  N N   . PRO A 1 28  ? 16.197  14.570 -19.833 1.00 48.00 ? 28  PRO C N   1 
ATOM   152  C CA  . PRO A 1 28  ? 14.941  14.677 -20.596 1.00 48.80 ? 28  PRO C CA  1 
ATOM   153  C C   . PRO A 1 28  ? 14.978  15.799 -21.641 1.00 47.57 ? 28  PRO C C   1 
ATOM   154  O O   . PRO A 1 28  ? 15.835  15.793 -22.531 1.00 51.01 ? 28  PRO C O   1 
ATOM   155  C CB  . PRO A 1 28  ? 13.889  14.980 -19.518 1.00 45.71 ? 28  PRO C CB  1 
ATOM   156  C CG  . PRO A 1 28  ? 14.506  14.521 -18.216 1.00 38.22 ? 28  PRO C CG  1 
ATOM   157  C CD  . PRO A 1 28  ? 15.990  14.743 -18.383 1.00 38.18 ? 28  PRO C CD  1 
ATOM   158  N N   . THR A 1 32  ? 18.944  22.940 -21.710 1.00 33.32 ? 32  THR C N   1 
ATOM   159  C CA  . THR A 1 32  ? 20.159  23.217 -22.463 1.00 33.44 ? 32  THR C CA  1 
ATOM   160  C C   . THR A 1 32  ? 21.339  23.653 -21.582 1.00 35.14 ? 32  THR C C   1 
ATOM   161  O O   . THR A 1 32  ? 22.494  23.499 -21.988 1.00 38.18 ? 32  THR C O   1 
ATOM   162  C CB  . THR A 1 32  ? 19.919  24.302 -23.525 1.00 36.66 ? 32  THR C CB  1 
ATOM   163  O OG1 . THR A 1 32  ? 21.110  24.477 -24.302 1.00 44.63 ? 32  THR C OG1 1 
ATOM   164  C CG2 . THR A 1 32  ? 19.537  25.636 -22.872 1.00 34.91 ? 32  THR C CG2 1 
ATOM   165  N N   . GLU A 1 33  ? 21.058  24.200 -20.394 1.00 30.85 ? 33  GLU C N   1 
ATOM   166  C CA  . GLU A 1 33  ? 22.097  24.633 -19.461 1.00 26.71 ? 33  GLU C CA  1 
ATOM   167  C C   . GLU A 1 33  ? 22.323  23.552 -18.409 1.00 26.37 ? 33  GLU C C   1 
ATOM   168  O O   . GLU A 1 33  ? 21.403  23.213 -17.655 1.00 24.28 ? 33  GLU C O   1 
ATOM   169  C CB  . GLU A 1 33  ? 21.744  25.960 -18.784 1.00 24.47 ? 33  GLU C CB  1 
ATOM   170  C CG  . GLU A 1 33  ? 22.794  26.356 -17.756 1.00 21.89 ? 33  GLU C CG  1 
ATOM   171  C CD  . GLU A 1 33  ? 22.652  27.754 -17.195 1.00 27.67 ? 33  GLU C CD  1 
ATOM   172  O OE1 . GLU A 1 33  ? 22.182  28.675 -17.912 1.00 32.67 ? 33  GLU C OE1 1 
ATOM   173  O OE2 . GLU A 1 33  ? 23.036  27.943 -16.018 1.00 23.91 ? 33  GLU C OE2 1 
ATOM   174  N N   . VAL A 1 34  ? 23.552  23.036 -18.346 1.00 22.44 ? 34  VAL C N   1 
ATOM   175  C CA  . VAL A 1 34  ? 23.932  21.965 -17.434 1.00 20.92 ? 34  VAL C CA  1 
ATOM   176  C C   . VAL A 1 34  ? 25.020  22.485 -16.505 1.00 22.71 ? 34  VAL C C   1 
ATOM   177  O O   . VAL A 1 34  ? 25.908  23.228 -16.933 1.00 21.95 ? 34  VAL C O   1 
ATOM   178  C CB  . VAL A 1 34  ? 24.420  20.721 -18.202 1.00 23.68 ? 34  VAL C CB  1 
ATOM   179  C CG1 . VAL A 1 34  ? 24.752  19.592 -17.245 1.00 20.53 ? 34  VAL C CG1 1 
ATOM   180  C CG2 . VAL A 1 34  ? 23.376  20.295 -19.230 1.00 23.71 ? 34  VAL C CG2 1 
ATOM   181  N N   . ARG A 1 35  ? 24.954  22.098 -15.236 1.00 19.16 ? 35  ARG C N   1 
ATOM   182  C CA  . ARG A 1 35  ? 25.944  22.494 -14.241 1.00 17.25 ? 35  ARG C CA  1 
ATOM   183  C C   . ARG A 1 35  ? 26.557  21.235 -13.662 1.00 18.15 ? 35  ARG C C   1 
ATOM   184  O O   . ARG A 1 35  ? 25.834  20.365 -13.174 1.00 16.70 ? 35  ARG C O   1 
ATOM   185  C CB  . ARG A 1 35  ? 25.302  23.325 -13.136 1.00 18.46 ? 35  ARG C CB  1 
ATOM   186  C CG  . ARG A 1 35  ? 26.279  23.902 -12.139 1.00 18.34 ? 35  ARG C CG  1 
ATOM   187  C CD  . ARG A 1 35  ? 25.533  24.785 -11.135 1.00 19.24 ? 35  ARG C CD  1 
ATOM   188  N NE  . ARG A 1 35  ? 26.457  25.367 -10.175 1.00 16.52 ? 35  ARG C NE  1 
ATOM   189  C CZ  . ARG A 1 35  ? 26.780  24.818 -9.016  1.00 18.37 ? 35  ARG C CZ  1 
ATOM   190  N NH1 . ARG A 1 35  ? 26.223  23.687 -8.603  1.00 17.39 ? 35  ARG C NH1 1 
ATOM   191  N NH2 . ARG A 1 35  ? 27.685  25.417 -8.253  1.00 19.00 ? 35  ARG C NH2 1 
ATOM   192  N N   . VAL A 1 36  ? 27.878  21.125 -13.729 1.00 17.38 ? 36  VAL C N   1 
ATOM   193  C CA  . VAL A 1 36  ? 28.578  19.925 -13.289 1.00 16.99 ? 36  VAL C CA  1 
ATOM   194  C C   . VAL A 1 36  ? 29.431  20.269 -12.082 1.00 18.81 ? 36  VAL C C   1 
ATOM   195  O O   . VAL A 1 36  ? 30.203  21.236 -12.112 1.00 17.66 ? 36  VAL C O   1 
ATOM   196  C CB  . VAL A 1 36  ? 29.431  19.324 -14.415 1.00 17.89 ? 36  VAL C CB  1 
ATOM   197  C CG1 . VAL A 1 36  ? 30.221  18.137 -13.893 1.00 19.76 ? 36  VAL C CG1 1 
ATOM   198  C CG2 . VAL A 1 36  ? 28.536  18.904 -15.555 1.00 22.44 ? 36  VAL C CG2 1 
ATOM   199  N N   . THR A 1 37  ? 29.300  19.475 -11.027 1.00 15.35 ? 37  THR C N   1 
ATOM   200  C CA  . THR A 1 37  ? 30.077  19.633 -9.807  1.00 19.19 ? 37  THR C CA  1 
ATOM   201  C C   . THR A 1 37  ? 30.714  18.302 -9.446  1.00 21.47 ? 37  THR C C   1 
ATOM   202  O O   . THR A 1 37  ? 30.065  17.255 -9.533  1.00 20.93 ? 37  THR C O   1 
ATOM   203  C CB  . THR A 1 37  ? 29.192  20.100 -8.638  1.00 17.65 ? 37  THR C CB  1 
ATOM   204  O OG1 . THR A 1 37  ? 28.588  21.344 -8.974  1.00 20.33 ? 37  THR C OG1 1 
ATOM   205  C CG2 . THR A 1 37  ? 30.025  20.279 -7.380  1.00 19.52 ? 37  THR C CG2 1 
ATOM   206  N N   . VAL A 1 38  ? 31.979  18.338 -9.036  1.00 20.86 ? 38  VAL C N   1 
ATOM   207  C CA  . VAL A 1 38  ? 32.631  17.173 -8.450  1.00 21.15 ? 38  VAL C CA  1 
ATOM   208  C C   . VAL A 1 38  ? 32.788  17.439 -6.963  1.00 23.42 ? 38  VAL C C   1 
ATOM   209  O O   . VAL A 1 38  ? 33.407  18.433 -6.560  1.00 22.24 ? 38  VAL C O   1 
ATOM   210  C CB  . VAL A 1 38  ? 33.983  16.868 -9.112  1.00 23.86 ? 38  VAL C CB  1 
ATOM   211  C CG1 . VAL A 1 38  ? 34.699  15.791 -8.338  1.00 24.47 ? 38  VAL C CG1 1 
ATOM   212  C CG2 . VAL A 1 38  ? 33.782  16.423 -10.562 1.00 19.57 ? 38  VAL C CG2 1 
ATOM   213  N N   . LEU A 1 39  ? 32.217  16.558 -6.147  1.00 20.93 ? 39  LEU C N   1 
ATOM   214  C CA  . LEU A 1 39  ? 32.306  16.659 -4.702  1.00 22.69 ? 39  LEU C CA  1 
ATOM   215  C C   . LEU A 1 39  ? 33.177  15.524 -4.176  1.00 24.58 ? 39  LEU C C   1 
ATOM   216  O O   . LEU A 1 39  ? 33.067  14.385 -4.632  1.00 27.22 ? 39  LEU C O   1 
ATOM   217  C CB  . LEU A 1 39  ? 30.915  16.606 -4.049  1.00 20.89 ? 39  LEU C CB  1 
ATOM   218  C CG  . LEU A 1 39  ? 29.917  17.687 -4.495  1.00 20.85 ? 39  LEU C CG  1 
ATOM   219  C CD1 . LEU A 1 39  ? 28.501  17.288 -4.120  1.00 18.25 ? 39  LEU C CD1 1 
ATOM   220  C CD2 . LEU A 1 39  ? 30.266  19.047 -3.886  1.00 20.04 ? 39  LEU C CD2 1 
ATOM   221  N N   . ARG A 1 40  ? 34.049  15.845 -3.229  1.00 27.57 ? 40  ARG C N   1 
ATOM   222  C CA  . ARG A 1 40  ? 34.836  14.841 -2.528  1.00 31.45 ? 40  ARG C CA  1 
ATOM   223  C C   . ARG A 1 40  ? 34.219  14.623 -1.155  1.00 30.33 ? 40  ARG C C   1 
ATOM   224  O O   . ARG A 1 40  ? 34.106  15.566 -0.363  1.00 31.42 ? 40  ARG C O   1 
ATOM   225  C CB  . ARG A 1 40  ? 36.302  15.257 -2.401  1.00 35.07 ? 40  ARG C CB  1 
ATOM   226  C CG  . ARG A 1 40  ? 37.067  14.455 -1.359  1.00 35.91 ? 40  ARG C CG  1 
ATOM   227  C CD  . ARG A 1 40  ? 38.533  14.821 -1.333  1.00 35.33 ? 40  ARG C CD  1 
ATOM   228  N NE  . ARG A 1 40  ? 39.347  13.769 -1.932  1.00 44.90 ? 40  ARG C NE  1 
ATOM   229  C CZ  . ARG A 1 40  ? 39.877  12.757 -1.257  1.00 49.20 ? 40  ARG C CZ  1 
ATOM   230  N NH1 . ARG A 1 40  ? 39.702  12.633 0.052   1.00 48.49 ? 40  ARG C NH1 1 
ATOM   231  N NH2 . ARG A 1 40  ? 40.605  11.851 -1.910  1.00 48.94 ? 40  ARG C NH2 1 
ATOM   232  N N   . GLN A 1 41  ? 33.827  13.382 -0.879  1.00 36.51 ? 41  GLN C N   1 
ATOM   233  C CA  . GLN A 1 41  ? 33.203  13.011 0.385   1.00 37.10 ? 41  GLN C CA  1 
ATOM   234  C C   . GLN A 1 41  ? 34.260  12.391 1.292   1.00 37.92 ? 41  GLN C C   1 
ATOM   235  O O   . GLN A 1 41  ? 34.756  11.293 1.015   1.00 36.53 ? 41  GLN C O   1 
ATOM   236  C CB  . GLN A 1 41  ? 32.052  12.040 0.151   1.00 37.46 ? 41  GLN C CB  1 
ATOM   237  C CG  . GLN A 1 41  ? 31.165  11.849 1.354   1.00 38.30 ? 41  GLN C CG  1 
ATOM   238  C CD  . GLN A 1 41  ? 29.910  11.096 0.994   1.00 38.16 ? 41  GLN C CD  1 
ATOM   239  O OE1 . GLN A 1 41  ? 29.969  10.051 0.341   1.00 40.29 ? 41  GLN C OE1 1 
ATOM   240  N NE2 . GLN A 1 41  ? 28.761  11.632 1.397   1.00 37.61 ? 41  GLN C NE2 1 
ATOM   241  N N   . ALA A 1 42  ? 34.599  13.098 2.369   1.00 40.89 ? 42  ALA C N   1 
ATOM   242  C CA  . ALA A 1 42  ? 35.600  12.670 3.334   1.00 43.99 ? 42  ALA C CA  1 
ATOM   243  C C   . ALA A 1 42  ? 34.947  12.612 4.705   1.00 47.67 ? 42  ALA C C   1 
ATOM   244  O O   . ALA A 1 42  ? 34.337  13.593 5.146   1.00 51.15 ? 42  ALA C O   1 
ATOM   245  C CB  . ALA A 1 42  ? 36.802  13.618 3.351   1.00 42.57 ? 42  ALA C CB  1 
ATOM   246  N N   . ASP A 1 43  ? 35.085  11.468 5.375   1.00 50.65 ? 43  ASP C N   1 
ATOM   247  C CA  . ASP A 1 43  ? 34.319  11.168 6.581   1.00 53.38 ? 43  ASP C CA  1 
ATOM   248  C C   . ASP A 1 43  ? 32.828  11.288 6.290   1.00 55.12 ? 43  ASP C C   1 
ATOM   249  O O   . ASP A 1 43  ? 32.282  10.536 5.470   1.00 51.70 ? 43  ASP C O   1 
ATOM   250  C CB  . ASP A 1 43  ? 34.734  12.091 7.732   1.00 54.41 ? 43  ASP C CB  1 
ATOM   251  C CG  . ASP A 1 43  ? 35.906  11.539 8.524   1.00 63.56 ? 43  ASP C CG  1 
ATOM   252  O OD1 . ASP A 1 43  ? 35.706  10.575 9.295   1.00 67.96 ? 43  ASP C OD1 1 
ATOM   253  O OD2 . ASP A 1 43  ? 37.032  12.053 8.357   1.00 66.93 ? 43  ASP C OD2 1 
ATOM   254  N N   . SER A 1 44  ? 32.161  12.224 6.957   1.00 52.52 ? 44  SER C N   1 
ATOM   255  C CA  . SER A 1 44  ? 30.772  12.560 6.676   1.00 52.45 ? 44  SER C CA  1 
ATOM   256  C C   . SER A 1 44  ? 30.669  14.017 6.247   1.00 52.24 ? 44  SER C C   1 
ATOM   257  O O   . SER A 1 44  ? 29.721  14.724 6.594   1.00 52.85 ? 44  SER C O   1 
ATOM   258  C CB  . SER A 1 44  ? 29.883  12.279 7.886   1.00 50.10 ? 44  SER C CB  1 
ATOM   259  N N   . GLN A 1 45  ? 31.669  14.479 5.497   1.00 49.04 ? 45  GLN C N   1 
ATOM   260  C CA  . GLN A 1 45  ? 31.763  15.847 5.018   1.00 46.11 ? 45  GLN C CA  1 
ATOM   261  C C   . GLN A 1 45  ? 31.974  15.859 3.510   1.00 44.06 ? 45  GLN C C   1 
ATOM   262  O O   . GLN A 1 45  ? 32.451  14.887 2.918   1.00 42.69 ? 45  GLN C O   1 
ATOM   263  C CB  . GLN A 1 45  ? 32.911  16.596 5.694   1.00 48.53 ? 45  GLN C CB  1 
ATOM   264  C CG  . GLN A 1 45  ? 32.533  17.318 6.966   1.00 53.34 ? 45  GLN C CG  1 
ATOM   265  C CD  . GLN A 1 45  ? 33.502  18.443 7.284   1.00 63.41 ? 45  GLN C CD  1 
ATOM   266  O OE1 . GLN A 1 45  ? 34.501  18.634 6.583   1.00 65.16 ? 45  GLN C OE1 1 
ATOM   267  N NE2 . GLN A 1 45  ? 33.209  19.201 8.338   1.00 60.44 ? 45  GLN C NE2 1 
ATOM   268  N N   . VAL A 1 46  ? 31.632  16.986 2.890   1.00 41.07 ? 46  VAL C N   1 
ATOM   269  C CA  . VAL A 1 46  ? 31.686  17.122 1.441   1.00 32.76 ? 46  VAL C CA  1 
ATOM   270  C C   . VAL A 1 46  ? 32.418  18.411 1.094   1.00 29.90 ? 46  VAL C C   1 
ATOM   271  O O   . VAL A 1 46  ? 32.134  19.469 1.667   1.00 32.94 ? 46  VAL C O   1 
ATOM   272  C CB  . VAL A 1 46  ? 30.274  17.088 0.825   1.00 33.04 ? 46  VAL C CB  1 
ATOM   273  C CG1 . VAL A 1 46  ? 30.199  17.921 -0.427  1.00 31.78 ? 46  VAL C CG1 1 
ATOM   274  C CG2 . VAL A 1 46  ? 29.891  15.654 0.507   1.00 36.73 ? 46  VAL C CG2 1 
ATOM   275  N N   . THR A 1 47  ? 33.376  18.312 0.179   1.00 30.17 ? 47  THR C N   1 
ATOM   276  C CA  . THR A 1 47  ? 34.129  19.447 -0.329  1.00 29.85 ? 47  THR C CA  1 
ATOM   277  C C   . THR A 1 47  ? 33.903  19.550 -1.834  1.00 28.47 ? 47  THR C C   1 
ATOM   278  O O   . THR A 1 47  ? 33.682  18.543 -2.510  1.00 27.97 ? 47  THR C O   1 
ATOM   279  C CB  . THR A 1 47  ? 35.636  19.293 -0.003  1.00 29.20 ? 47  THR C CB  1 
ATOM   280  O OG1 . THR A 1 47  ? 35.804  19.215 1.417   1.00 34.38 ? 47  THR C OG1 1 
ATOM   281  C CG2 . THR A 1 47  ? 36.446  20.467 -0.514  1.00 32.47 ? 47  THR C CG2 1 
ATOM   282  N N   . GLU A 1 48  ? 33.938  20.774 -2.359  1.00 29.22 ? 48  GLU C N   1 
ATOM   283  C CA  . GLU A 1 48  ? 33.833  20.996 -3.798  1.00 28.50 ? 48  GLU C CA  1 
ATOM   284  C C   . GLU A 1 48  ? 35.219  20.925 -4.431  1.00 28.36 ? 48  GLU C C   1 
ATOM   285  O O   . GLU A 1 48  ? 36.112  21.697 -4.070  1.00 29.51 ? 48  GLU C O   1 
ATOM   286  C CB  . GLU A 1 48  ? 33.187  22.347 -4.107  1.00 25.21 ? 48  GLU C CB  1 
ATOM   287  C CG  . GLU A 1 48  ? 33.123  22.638 -5.599  1.00 29.13 ? 48  GLU C CG  1 
ATOM   288  C CD  . GLU A 1 48  ? 32.625  24.038 -5.900  1.00 30.54 ? 48  GLU C CD  1 
ATOM   289  O OE1 . GLU A 1 48  ? 31.426  24.299 -5.666  1.00 31.85 ? 48  GLU C OE1 1 
ATOM   290  O OE2 . GLU A 1 48  ? 33.438  24.872 -6.360  1.00 33.35 ? 48  GLU C OE2 1 
ATOM   291  N N   . VAL A 1 49  ? 35.390  20.013 -5.379  1.00 25.97 ? 49  VAL C N   1 
ATOM   292  C CA  . VAL A 1 49  ? 36.638  19.922 -6.125  1.00 27.83 ? 49  VAL C CA  1 
ATOM   293  C C   . VAL A 1 49  ? 36.583  20.781 -7.380  1.00 32.44 ? 49  VAL C C   1 
ATOM   294  O O   . VAL A 1 49  ? 37.530  21.511 -7.685  1.00 37.36 ? 49  VAL C O   1 
ATOM   295  C CB  . VAL A 1 49  ? 36.937  18.448 -6.467  1.00 27.98 ? 49  VAL C CB  1 
ATOM   296  C CG1 . VAL A 1 49  ? 38.327  18.317 -7.071  1.00 29.67 ? 49  VAL C CG1 1 
ATOM   297  C CG2 . VAL A 1 49  ? 36.822  17.581 -5.230  1.00 26.37 ? 49  VAL C CG2 1 
ATOM   298  N N   . CYS A 1 50  ? 35.469  20.721 -8.104  1.00 30.42 ? 50  CYS C N   1 
ATOM   299  C CA  . CYS A 1 50  ? 35.369  21.256 -9.453  1.00 30.81 ? 50  CYS C CA  1 
ATOM   300  C C   . CYS A 1 50  ? 33.929  21.661 -9.714  1.00 25.65 ? 50  CYS C C   1 
ATOM   301  O O   . CYS A 1 50  ? 33.002  20.991 -9.260  1.00 22.80 ? 50  CYS C O   1 
ATOM   302  C CB  . CYS A 1 50  ? 35.789  20.210 -10.497 1.00 26.41 ? 50  CYS C CB  1 
ATOM   303  S SG  . CYS A 1 50  ? 37.356  19.414 -10.170 1.00 48.32 ? 50  CYS C SG  1 
ATOM   304  N N   . ALA A 1 51  ? 33.744  22.745 -10.469 1.00 26.69 ? 51  ALA C N   1 
ATOM   305  C CA  . ALA A 1 51  ? 32.405  23.140 -10.892 1.00 21.74 ? 51  ALA C CA  1 
ATOM   306  C C   . ALA A 1 51  ? 32.489  23.929 -12.189 1.00 21.12 ? 51  ALA C C   1 
ATOM   307  O O   . ALA A 1 51  ? 33.426  24.703 -12.394 1.00 22.06 ? 51  ALA C O   1 
ATOM   308  C CB  . ALA A 1 51  ? 31.690  23.970 -9.819  1.00 24.43 ? 51  ALA C CB  1 
ATOM   309  N N   . ALA A 1 52  ? 31.512  23.713 -13.066 1.00 19.07 ? 52  ALA C N   1 
ATOM   310  C CA  . ALA A 1 52  ? 31.425  24.445 -14.321 1.00 17.78 ? 52  ALA C CA  1 
ATOM   311  C C   . ALA A 1 52  ? 30.022  24.308 -14.878 1.00 18.56 ? 52  ALA C C   1 
ATOM   312  O O   . ALA A 1 52  ? 29.319  23.334 -14.599 1.00 19.09 ? 52  ALA C O   1 
ATOM   313  C CB  . ALA A 1 52  ? 32.446  23.945 -15.352 1.00 21.34 ? 52  ALA C CB  1 
ATOM   314  N N   . THR A 1 53  ? 29.617  25.311 -15.653 1.00 18.52 ? 53  THR C N   1 
ATOM   315  C CA  . THR A 1 53  ? 28.361  25.293 -16.384 1.00 20.11 ? 53  THR C CA  1 
ATOM   316  C C   . THR A 1 53  ? 28.670  25.223 -17.870 1.00 23.18 ? 53  THR C C   1 
ATOM   317  O O   . THR A 1 53  ? 29.484  26.003 -18.373 1.00 20.23 ? 53  THR C O   1 
ATOM   318  C CB  . THR A 1 53  ? 27.517  26.538 -16.078 1.00 22.96 ? 53  THR C CB  1 
ATOM   319  O OG1 . THR A 1 53  ? 27.091  26.517 -14.708 1.00 21.13 ? 53  THR C OG1 1 
ATOM   320  C CG2 . THR A 1 53  ? 26.284  26.599 -16.987 1.00 23.42 ? 53  THR C CG2 1 
ATOM   321  N N   . TYR A 1 54  ? 28.044  24.282 -18.569 1.00 23.57 ? 54  TYR C N   1 
ATOM   322  C CA  . TYR A 1 54  ? 28.144  24.243 -20.017 1.00 27.06 ? 54  TYR C CA  1 
ATOM   323  C C   . TYR A 1 54  ? 26.744  24.248 -20.607 1.00 31.06 ? 54  TYR C C   1 
ATOM   324  O O   . TYR A 1 54  ? 25.773  23.842 -19.961 1.00 28.35 ? 54  TYR C O   1 
ATOM   325  C CB  . TYR A 1 54  ? 28.987  23.047 -20.514 1.00 27.01 ? 54  TYR C CB  1 
ATOM   326  C CG  . TYR A 1 54  ? 28.381  21.665 -20.399 1.00 27.94 ? 54  TYR C CG  1 
ATOM   327  C CD1 . TYR A 1 54  ? 27.608  21.135 -21.430 1.00 32.41 ? 54  TYR C CD1 1 
ATOM   328  C CD2 . TYR A 1 54  ? 28.634  20.866 -19.294 1.00 27.89 ? 54  TYR C CD2 1 
ATOM   329  C CE1 . TYR A 1 54  ? 27.072  19.857 -21.345 1.00 32.63 ? 54  TYR C CE1 1 
ATOM   330  C CE2 . TYR A 1 54  ? 28.105  19.586 -19.196 1.00 26.23 ? 54  TYR C CE2 1 
ATOM   331  C CZ  . TYR A 1 54  ? 27.322  19.085 -20.222 1.00 31.40 ? 54  TYR C CZ  1 
ATOM   332  O OH  . TYR A 1 54  ? 26.788  17.808 -20.129 1.00 34.66 ? 54  TYR C OH  1 
ATOM   333  N N   . MET A 1 55  ? 26.645  24.767 -21.833 1.00 30.83 ? 55  MET C N   1 
ATOM   334  C CA  . MET A 1 55  ? 25.364  25.093 -22.464 1.00 37.01 ? 55  MET C CA  1 
ATOM   335  C C   . MET A 1 55  ? 25.350  24.441 -23.837 1.00 43.84 ? 55  MET C C   1 
ATOM   336  O O   . MET A 1 55  ? 25.537  25.142 -24.836 1.00 47.95 ? 55  MET C O   1 
ATOM   337  C CB  . MET A 1 55  ? 25.168  26.627 -22.565 1.00 38.82 ? 55  MET C CB  1 
ATOM   338  C CG  . MET A 1 55  ? 25.164  27.379 -21.235 1.00 36.66 ? 55  MET C CG  1 
ATOM   339  S SD  . MET A 1 55  ? 26.143  28.912 -21.284 1.00 44.74 ? 55  MET C SD  1 
ATOM   340  C CE  . MET A 1 55  ? 25.540  29.782 -19.850 1.00 33.00 ? 55  MET C CE  1 
ATOM   341  N N   . MET A 1 56  ? 25.131  23.120 -23.871 1.00 44.62 ? 56  MET C N   1 
ATOM   342  C CA  . MET A 1 56  ? 25.197  22.320 -25.104 1.00 49.68 ? 56  MET C CA  1 
ATOM   343  C C   . MET A 1 56  ? 24.765  23.089 -26.354 1.00 52.13 ? 56  MET C C   1 
ATOM   344  O O   . MET A 1 56  ? 23.588  23.412 -26.523 1.00 55.46 ? 56  MET C O   1 
ATOM   345  C CB  . MET A 1 56  ? 24.334  21.065 -24.972 1.00 46.14 ? 56  MET C CB  1 
ATOM   346  C CG  . MET A 1 56  ? 24.814  19.871 -25.817 1.00 49.58 ? 56  MET C CG  1 
ATOM   347  S SD  . MET A 1 56  ? 25.213  20.199 -27.559 1.00 62.60 ? 56  MET C SD  1 
ATOM   348  C CE  . MET A 1 56  ? 23.589  20.533 -28.248 1.00 50.84 ? 56  MET C CE  1 
ATOM   349  N N   . ILE A 1 67  ? 43.032  21.931 -12.114 1.00 41.71 ? 67  ILE C N   1 
ATOM   350  C CA  . ILE A 1 67  ? 42.686  20.711 -11.385 1.00 44.57 ? 67  ILE C CA  1 
ATOM   351  C C   . ILE A 1 67  ? 41.839  19.772 -12.232 1.00 45.21 ? 67  ILE C C   1 
ATOM   352  O O   . ILE A 1 67  ? 42.082  18.562 -12.295 1.00 43.73 ? 67  ILE C O   1 
ATOM   353  C CB  . ILE A 1 67  ? 41.934  21.031 -10.085 1.00 41.53 ? 67  ILE C CB  1 
ATOM   354  C CG1 . ILE A 1 67  ? 42.824  21.826 -9.126  1.00 42.93 ? 67  ILE C CG1 1 
ATOM   355  C CG2 . ILE A 1 67  ? 41.417  19.744 -9.454  1.00 46.45 ? 67  ILE C CG2 1 
ATOM   356  C CD1 . ILE A 1 67  ? 43.064  21.149 -7.786  1.00 44.89 ? 67  ILE C CD1 1 
ATOM   357  N N   . CYS A 1 68  ? 40.829  20.344 -12.875 1.00 41.76 ? 68  CYS C N   1 
ATOM   358  C CA  . CYS A 1 68  ? 39.798  19.571 -13.539 1.00 38.73 ? 68  CYS C CA  1 
ATOM   359  C C   . CYS A 1 68  ? 39.778  19.873 -15.027 1.00 39.38 ? 68  CYS C C   1 
ATOM   360  O O   . CYS A 1 68  ? 40.127  20.975 -15.461 1.00 43.46 ? 68  CYS C O   1 
ATOM   361  C CB  . CYS A 1 68  ? 38.434  19.870 -12.928 1.00 42.51 ? 68  CYS C CB  1 
ATOM   362  S SG  . CYS A 1 68  ? 37.810  18.529 -11.920 1.00 50.08 ? 68  CYS C SG  1 
ATOM   363  N N   . THR A 1 69  ? 39.357  18.880 -15.804 1.00 37.51 ? 69  THR C N   1 
ATOM   364  C CA  . THR A 1 69  ? 39.200  19.027 -17.244 1.00 37.89 ? 69  THR C CA  1 
ATOM   365  C C   . THR A 1 69  ? 37.919  18.315 -17.640 1.00 38.71 ? 69  THR C C   1 
ATOM   366  O O   . THR A 1 69  ? 37.780  17.110 -17.408 1.00 38.63 ? 69  THR C O   1 
ATOM   367  C CB  . THR A 1 69  ? 40.405  18.453 -18.006 1.00 39.73 ? 69  THR C CB  1 
ATOM   368  O OG1 . THR A 1 69  ? 41.622  18.927 -17.411 1.00 39.85 ? 69  THR C OG1 1 
ATOM   369  C CG2 . THR A 1 69  ? 40.364  18.888 -19.465 1.00 34.86 ? 69  THR C CG2 1 
ATOM   370  N N   . GLY A 1 70  ? 36.986  19.057 -18.229 1.00 37.71 ? 70  GLY C N   1 
ATOM   371  C CA  . GLY A 1 70  ? 35.703  18.490 -18.589 1.00 35.37 ? 70  GLY C CA  1 
ATOM   372  C C   . GLY A 1 70  ? 35.329  18.701 -20.039 1.00 39.02 ? 70  GLY C C   1 
ATOM   373  O O   . GLY A 1 70  ? 35.338  19.835 -20.534 1.00 38.47 ? 70  GLY C O   1 
ATOM   374  N N   . THR A 1 71  ? 35.005  17.609 -20.728 1.00 35.80 ? 71  THR C N   1 
ATOM   375  C CA  . THR A 1 71  ? 34.543  17.642 -22.107 1.00 37.49 ? 71  THR C CA  1 
ATOM   376  C C   . THR A 1 71  ? 33.184  16.963 -22.188 1.00 38.86 ? 71  THR C C   1 
ATOM   377  O O   . THR A 1 71  ? 32.989  15.884 -21.621 1.00 37.80 ? 71  THR C O   1 
ATOM   378  C CB  . THR A 1 71  ? 35.528  16.939 -23.044 1.00 38.48 ? 71  THR C CB  1 
ATOM   379  O OG1 . THR A 1 71  ? 35.235  15.536 -23.070 1.00 46.09 ? 71  THR C OG1 1 
ATOM   380  C CG2 . THR A 1 71  ? 36.959  17.140 -22.562 1.00 36.69 ? 71  THR C CG2 1 
ATOM   381  N N   . SER A 1 72  ? 32.248  17.595 -22.895 1.00 43.62 ? 72  SER C N   1 
ATOM   382  C CA  . SER A 1 72  ? 30.880  17.097 -23.015 1.00 41.34 ? 72  SER C CA  1 
ATOM   383  C C   . SER A 1 72  ? 30.699  16.446 -24.385 1.00 45.73 ? 72  SER C C   1 
ATOM   384  O O   . SER A 1 72  ? 30.797  17.118 -25.418 1.00 45.10 ? 72  SER C O   1 
ATOM   385  C CB  . SER A 1 72  ? 29.876  18.230 -22.808 1.00 38.34 ? 72  SER C CB  1 
ATOM   386  O OG  . SER A 1 72  ? 29.959  19.187 -23.851 1.00 42.18 ? 72  SER C OG  1 
ATOM   387  N N   . SER A 1 73  ? 30.433  15.140 -24.391 1.00 45.65 ? 73  SER C N   1 
ATOM   388  C CA  . SER A 1 73  ? 30.111  14.389 -25.603 1.00 43.55 ? 73  SER C CA  1 
ATOM   389  C C   . SER A 1 73  ? 28.697  13.841 -25.430 1.00 46.52 ? 73  SER C C   1 
ATOM   390  O O   . SER A 1 73  ? 28.500  12.769 -24.851 1.00 48.56 ? 73  SER C O   1 
ATOM   391  C CB  . SER A 1 73  ? 31.124  13.268 -25.861 1.00 40.92 ? 73  SER C CB  1 
ATOM   392  N N   . GLY A 1 74  ? 27.711  14.585 -25.928 1.00 42.66 ? 74  GLY C N   1 
ATOM   393  C CA  . GLY A 1 74  ? 26.329  14.163 -25.774 1.00 42.43 ? 74  GLY C CA  1 
ATOM   394  C C   . GLY A 1 74  ? 25.885  14.277 -24.328 1.00 46.67 ? 74  GLY C C   1 
ATOM   395  O O   . GLY A 1 74  ? 26.147  15.275 -23.646 1.00 49.28 ? 74  GLY C O   1 
ATOM   396  N N   . ASN A 1 75  ? 25.206  13.237 -23.849 1.00 45.26 ? 75  ASN C N   1 
ATOM   397  C CA  . ASN A 1 75  ? 24.753  13.172 -22.459 1.00 45.58 ? 75  ASN C CA  1 
ATOM   398  C C   . ASN A 1 75  ? 25.792  12.498 -21.566 1.00 42.78 ? 75  ASN C C   1 
ATOM   399  O O   . ASN A 1 75  ? 25.482  11.618 -20.767 1.00 44.68 ? 75  ASN C O   1 
ATOM   400  C CB  . ASN A 1 75  ? 23.408  12.456 -22.382 1.00 44.48 ? 75  ASN C CB  1 
ATOM   401  C CG  . ASN A 1 75  ? 22.234  13.374 -22.708 1.00 46.86 ? 75  ASN C CG  1 
ATOM   402  O OD1 . ASN A 1 75  ? 21.205  13.351 -22.027 1.00 48.30 ? 75  ASN C OD1 1 
ATOM   403  N ND2 . ASN A 1 75  ? 22.385  14.189 -23.749 1.00 46.34 ? 75  ASN C ND2 1 
ATOM   404  N N   . GLN A 1 76  ? 27.050  12.909 -21.707 1.00 44.68 ? 76  GLN C N   1 
ATOM   405  C CA  . GLN A 1 76  ? 28.112  12.426 -20.836 1.00 42.44 ? 76  GLN C CA  1 
ATOM   406  C C   . GLN A 1 76  ? 29.189  13.494 -20.755 1.00 39.73 ? 76  GLN C C   1 
ATOM   407  O O   . GLN A 1 76  ? 29.363  14.286 -21.685 1.00 40.79 ? 76  GLN C O   1 
ATOM   408  C CB  . GLN A 1 76  ? 28.713  11.108 -21.334 1.00 44.52 ? 76  GLN C CB  1 
ATOM   409  C CG  . GLN A 1 76  ? 29.845  11.272 -22.337 1.00 45.34 ? 76  GLN C CG  1 
ATOM   410  C CD  . GLN A 1 76  ? 30.308  9.946  -22.920 1.00 51.24 ? 76  GLN C CD  1 
ATOM   411  O OE1 . GLN A 1 76  ? 30.677  9.026  -22.187 1.00 54.26 ? 76  GLN C OE1 1 
ATOM   412  N NE2 . GLN A 1 76  ? 30.290  9.842  -24.247 1.00 52.46 ? 76  GLN C NE2 1 
ATOM   413  N N   . VAL A 1 77  ? 29.897  13.519 -19.627 1.00 36.84 ? 77  VAL C N   1 
ATOM   414  C CA  . VAL A 1 77  ? 31.027  14.418 -19.430 1.00 37.74 ? 77  VAL C CA  1 
ATOM   415  C C   . VAL A 1 77  ? 32.241  13.583 -19.051 1.00 37.15 ? 77  VAL C C   1 
ATOM   416  O O   . VAL A 1 77  ? 32.156  12.701 -18.187 1.00 33.93 ? 77  VAL C O   1 
ATOM   417  C CB  . VAL A 1 77  ? 30.743  15.513 -18.377 1.00 34.05 ? 77  VAL C CB  1 
ATOM   418  C CG1 . VAL A 1 77  ? 29.579  16.387 -18.821 1.00 36.51 ? 77  VAL C CG1 1 
ATOM   419  C CG2 . VAL A 1 77  ? 30.465  14.926 -17.008 1.00 34.98 ? 77  VAL C CG2 1 
ATOM   420  N N   . ASN A 1 78  ? 33.357  13.838 -19.727 1.00 37.30 ? 78  ASN C N   1 
ATOM   421  C CA  . ASN A 1 78  ? 34.621  13.179 -19.426 1.00 37.08 ? 78  ASN C CA  1 
ATOM   422  C C   . ASN A 1 78  ? 35.381  14.079 -18.463 1.00 35.92 ? 78  ASN C C   1 
ATOM   423  O O   . ASN A 1 78  ? 35.812  15.175 -18.838 1.00 36.06 ? 78  ASN C O   1 
ATOM   424  C CB  . ASN A 1 78  ? 35.415  12.921 -20.705 1.00 36.18 ? 78  ASN C CB  1 
ATOM   425  N N   . LEU A 1 79  ? 35.524  13.632 -17.218 1.00 35.20 ? 79  LEU C N   1 
ATOM   426  C CA  . LEU A 1 79  ? 36.106  14.440 -16.153 1.00 34.55 ? 79  LEU C CA  1 
ATOM   427  C C   . LEU A 1 79  ? 37.489  13.907 -15.804 1.00 37.24 ? 79  LEU C C   1 
ATOM   428  O O   . LEU A 1 79  ? 37.625  12.764 -15.353 1.00 38.21 ? 79  LEU C O   1 
ATOM   429  C CB  . LEU A 1 79  ? 35.203  14.450 -14.916 1.00 32.76 ? 79  LEU C CB  1 
ATOM   430  N N   . THR A 1 80  ? 38.507  14.739 -15.998 1.00 35.35 ? 80  THR C N   1 
ATOM   431  C CA  . THR A 1 80  ? 39.883  14.406 -15.656 1.00 36.19 ? 80  THR C CA  1 
ATOM   432  C C   . THR A 1 80  ? 40.312  15.255 -14.469 1.00 37.66 ? 80  THR C C   1 
ATOM   433  O O   . THR A 1 80  ? 40.259  16.489 -14.531 1.00 38.16 ? 80  THR C O   1 
ATOM   434  C CB  . THR A 1 80  ? 40.823  14.638 -16.840 1.00 36.20 ? 80  THR C CB  1 
ATOM   435  O OG1 . THR A 1 80  ? 40.490  13.747 -17.914 1.00 35.72 ? 80  THR C OG1 1 
ATOM   436  C CG2 . THR A 1 80  ? 42.256  14.408 -16.423 1.00 38.01 ? 80  THR C CG2 1 
ATOM   437  N N   . ILE A 1 81  ? 40.731  14.599 -13.395 1.00 35.66 ? 81  ILE C N   1 
ATOM   438  C CA  . ILE A 1 81  ? 41.283  15.275 -12.228 1.00 37.53 ? 81  ILE C CA  1 
ATOM   439  C C   . ILE A 1 81  ? 42.790  15.067 -12.234 1.00 45.70 ? 81  ILE C C   1 
ATOM   440  O O   . ILE A 1 81  ? 43.298  14.081 -12.787 1.00 45.69 ? 81  ILE C O   1 
ATOM   441  C CB  . ILE A 1 81  ? 40.644  14.764 -10.920 1.00 38.98 ? 81  ILE C CB  1 
ATOM   442  C CG1 . ILE A 1 81  ? 39.123  14.948 -10.962 1.00 37.75 ? 81  ILE C CG1 1 
ATOM   443  C CG2 . ILE A 1 81  ? 41.208  15.487 -9.705  1.00 39.53 ? 81  ILE C CG2 1 
ATOM   444  C CD1 . ILE A 1 81  ? 38.439  14.584 -9.651  1.00 32.91 ? 81  ILE C CD1 1 
ATOM   445  N N   . GLN A 1 82  ? 43.516  16.010 -11.631 1.00 47.35 ? 82  GLN C N   1 
ATOM   446  C CA  . GLN A 1 82  ? 44.971  15.973 -11.586 1.00 45.69 ? 82  GLN C CA  1 
ATOM   447  C C   . GLN A 1 82  ? 45.430  16.438 -10.212 1.00 47.77 ? 82  GLN C C   1 
ATOM   448  O O   . GLN A 1 82  ? 44.619  16.815 -9.360  1.00 50.46 ? 82  GLN C O   1 
ATOM   449  C CB  . GLN A 1 82  ? 45.583  16.830 -12.705 1.00 45.49 ? 82  GLN C CB  1 
ATOM   450  C CG  . GLN A 1 82  ? 45.265  18.309 -12.596 1.00 46.81 ? 82  GLN C CG  1 
ATOM   451  C CD  . GLN A 1 82  ? 45.415  19.037 -13.920 1.00 50.82 ? 82  GLN C CD  1 
ATOM   452  O OE1 . GLN A 1 82  ? 45.684  18.418 -14.952 1.00 52.79 ? 82  GLN C OE1 1 
ATOM   453  N NE2 . GLN A 1 82  ? 45.229  20.357 -13.899 1.00 47.61 ? 82  GLN C NE2 1 
ATOM   454  N N   . GLY A 1 83  ? 46.744  16.403 -9.998  1.00 47.84 ? 83  GLY C N   1 
ATOM   455  C CA  . GLY A 1 83  ? 47.318  16.818 -8.733  1.00 45.11 ? 83  GLY C CA  1 
ATOM   456  C C   . GLY A 1 83  ? 47.007  15.906 -7.569  1.00 44.26 ? 83  GLY C C   1 
ATOM   457  O O   . GLY A 1 83  ? 46.973  16.366 -6.423  1.00 45.98 ? 83  GLY C O   1 
ATOM   458  N N   . LEU A 1 84  ? 46.786  14.622 -7.827  1.00 46.84 ? 84  LEU C N   1 
ATOM   459  C CA  . LEU A 1 84  ? 46.376  13.684 -6.783  1.00 48.93 ? 84  LEU C CA  1 
ATOM   460  C C   . LEU A 1 84  ? 47.572  13.056 -6.073  1.00 47.36 ? 84  LEU C C   1 
ATOM   461  O O   . LEU A 1 84  ? 48.717  13.297 -6.448  1.00 55.88 ? 84  LEU C O   1 
ATOM   462  C CB  . LEU A 1 84  ? 45.484  12.591 -7.380  1.00 47.28 ? 84  LEU C CB  1 
ATOM   463  C CG  . LEU A 1 84  ? 44.178  13.086 -8.006  1.00 43.85 ? 84  LEU C CG  1 
ATOM   464  C CD1 . LEU A 1 84  ? 43.523  11.999 -8.843  1.00 45.31 ? 84  LEU C CD1 1 
ATOM   465  C CD2 . LEU A 1 84  ? 43.232  13.561 -6.927  1.00 43.39 ? 84  LEU C CD2 1 
ATOM   466  N N   . GLY A 1 90  ? 39.872  8.219  -2.203  1.00 43.19 ? 90  GLY C N   1 
ATOM   467  C CA  . GLY A 1 90  ? 38.699  8.953  -1.753  1.00 43.79 ? 90  GLY C CA  1 
ATOM   468  C C   . GLY A 1 90  ? 37.500  8.756  -2.661  1.00 42.02 ? 90  GLY C C   1 
ATOM   469  O O   . GLY A 1 90  ? 37.624  8.177  -3.749  1.00 44.08 ? 90  GLY C O   1 
ATOM   470  N N   . LEU A 1 91  ? 36.332  9.230  -2.229  1.00 40.16 ? 91  LEU C N   1 
ATOM   471  C CA  . LEU A 1 91  ? 35.108  9.088  -3.009  1.00 36.32 ? 91  LEU C CA  1 
ATOM   472  C C   . LEU A 1 91  ? 34.760  10.424 -3.659  1.00 32.31 ? 91  LEU C C   1 
ATOM   473  O O   . LEU A 1 91  ? 34.510  11.420 -2.967  1.00 33.07 ? 91  LEU C O   1 
ATOM   474  C CB  . LEU A 1 91  ? 33.948  8.587  -2.152  1.00 34.41 ? 91  LEU C CB  1 
ATOM   475  C CG  . LEU A 1 91  ? 32.724  8.210  -2.985  1.00 33.21 ? 91  LEU C CG  1 
ATOM   476  C CD1 . LEU A 1 91  ? 33.019  6.996  -3.870  1.00 34.83 ? 91  LEU C CD1 1 
ATOM   477  C CD2 . LEU A 1 91  ? 31.503  7.980  -2.101  1.00 35.56 ? 91  LEU C CD2 1 
ATOM   478  N N   . TYR A 1 92  ? 34.742  10.431 -4.985  1.00 30.89 ? 92  TYR C N   1 
ATOM   479  C CA  . TYR A 1 92  ? 34.530  11.630 -5.784  1.00 29.71 ? 92  TYR C CA  1 
ATOM   480  C C   . TYR A 1 92  ? 33.157  11.517 -6.420  1.00 28.40 ? 92  TYR C C   1 
ATOM   481  O O   . TYR A 1 92  ? 32.932  10.662 -7.284  1.00 29.57 ? 92  TYR C O   1 
ATOM   482  C CB  . TYR A 1 92  ? 35.636  11.790 -6.824  1.00 29.95 ? 92  TYR C CB  1 
ATOM   483  C CG  . TYR A 1 92  ? 36.928  12.202 -6.172  1.00 33.45 ? 92  TYR C CG  1 
ATOM   484  C CD1 . TYR A 1 92  ? 37.751  11.265 -5.562  1.00 37.15 ? 92  TYR C CD1 1 
ATOM   485  C CD2 . TYR A 1 92  ? 37.306  13.535 -6.124  1.00 33.29 ? 92  TYR C CD2 1 
ATOM   486  C CE1 . TYR A 1 92  ? 38.924  11.646 -4.936  1.00 38.51 ? 92  TYR C CE1 1 
ATOM   487  C CE2 . TYR A 1 92  ? 38.480  13.925 -5.507  1.00 38.01 ? 92  TYR C CE2 1 
ATOM   488  C CZ  . TYR A 1 92  ? 39.289  12.972 -4.918  1.00 39.88 ? 92  TYR C CZ  1 
ATOM   489  O OH  . TYR A 1 92  ? 40.457  13.345 -4.297  1.00 40.25 ? 92  TYR C OH  1 
ATOM   490  N N   . ILE A 1 93  ? 32.243  12.373 -5.978  1.00 27.34 ? 93  ILE C N   1 
ATOM   491  C CA  . ILE A 1 93  ? 30.851  12.298 -6.391  1.00 22.97 ? 93  ILE C CA  1 
ATOM   492  C C   . ILE A 1 93  ? 30.634  13.226 -7.573  1.00 25.33 ? 93  ILE C C   1 
ATOM   493  O O   . ILE A 1 93  ? 30.986  14.411 -7.520  1.00 23.00 ? 93  ILE C O   1 
ATOM   494  C CB  . ILE A 1 93  ? 29.917  12.651 -5.224  1.00 23.95 ? 93  ILE C CB  1 
ATOM   495  C CG1 . ILE A 1 93  ? 30.128  11.648 -4.080  1.00 28.54 ? 93  ILE C CG1 1 
ATOM   496  C CG2 . ILE A 1 93  ? 28.471  12.630 -5.689  1.00 21.61 ? 93  ILE C CG2 1 
ATOM   497  C CD1 . ILE A 1 93  ? 29.519  12.049 -2.757  1.00 28.69 ? 93  ILE C CD1 1 
ATOM   498  N N   . CYS A 1 94  ? 30.055  12.684 -8.639  1.00 22.83 ? 94  CYS C N   1 
ATOM   499  C CA  . CYS A 1 94  ? 29.693  13.452 -9.818  1.00 23.44 ? 94  CYS C CA  1 
ATOM   500  C C   . CYS A 1 94  ? 28.257  13.950 -9.674  1.00 22.60 ? 94  CYS C C   1 
ATOM   501  O O   . CYS A 1 94  ? 27.333  13.148 -9.507  1.00 23.18 ? 94  CYS C O   1 
ATOM   502  C CB  . CYS A 1 94  ? 29.842  12.596 -11.069 1.00 28.01 ? 94  CYS C CB  1 
ATOM   503  S SG  . CYS A 1 94  ? 29.765  13.569 -12.560 1.00 48.81 ? 94  CYS C SG  1 
ATOM   504  N N   . LYS A 1 95  ? 28.077  15.267 -9.736  1.00 17.91 ? 95  LYS C N   1 
ATOM   505  C CA  . LYS A 1 95  ? 26.772  15.907 -9.592  1.00 19.36 ? 95  LYS C CA  1 
ATOM   506  C C   . LYS A 1 95  ? 26.448  16.678 -10.864 1.00 19.10 ? 95  LYS C C   1 
ATOM   507  O O   . LYS A 1 95  ? 27.239  17.523 -11.302 1.00 18.75 ? 95  LYS C O   1 
ATOM   508  C CB  . LYS A 1 95  ? 26.752  16.843 -8.377  1.00 17.34 ? 95  LYS C CB  1 
ATOM   509  C CG  . LYS A 1 95  ? 25.496  17.717 -8.238  1.00 15.83 ? 95  LYS C CG  1 
ATOM   510  C CD  . LYS A 1 95  ? 25.677  18.699 -7.062  1.00 15.05 ? 95  LYS C CD  1 
ATOM   511  C CE  . LYS A 1 95  ? 24.510  19.676 -6.913  1.00 13.01 ? 95  LYS C CE  1 
ATOM   512  N NZ  . LYS A 1 95  ? 24.791  20.616 -5.786  1.00 13.09 ? 95  LYS C NZ  1 
ATOM   513  N N   . VAL A 1 96  ? 25.278  16.400 -11.437 1.00 19.71 ? 96  VAL C N   1 
ATOM   514  C CA  . VAL A 1 96  ? 24.829  17.006 -12.684 1.00 18.98 ? 96  VAL C CA  1 
ATOM   515  C C   . VAL A 1 96  ? 23.473  17.648 -12.445 1.00 18.26 ? 96  VAL C C   1 
ATOM   516  O O   . VAL A 1 96  ? 22.578  17.030 -11.849 1.00 18.60 ? 96  VAL C O   1 
ATOM   517  C CB  . VAL A 1 96  ? 24.747  15.972 -13.826 1.00 21.99 ? 96  VAL C CB  1 
ATOM   518  N N   . GLU A 1 97  ? 23.313  18.877 -12.921 1.00 16.14 ? 97  GLU C N   1 
ATOM   519  C CA  . GLU A 1 97  ? 22.070  19.615 -12.745 1.00 15.16 ? 97  GLU C CA  1 
ATOM   520  C C   . GLU A 1 97  ? 21.603  20.182 -14.074 1.00 22.27 ? 97  GLU C C   1 
ATOM   521  O O   . GLU A 1 97  ? 22.361  20.885 -14.758 1.00 20.25 ? 97  GLU C O   1 
ATOM   522  C CB  . GLU A 1 97  ? 22.243  20.753 -11.749 1.00 16.22 ? 97  GLU C CB  1 
ATOM   523  C CG  . GLU A 1 97  ? 22.606  20.305 -10.361 1.00 14.65 ? 97  GLU C CG  1 
ATOM   524  C CD  . GLU A 1 97  ? 23.080  21.462 -9.540  1.00 14.10 ? 97  GLU C CD  1 
ATOM   525  O OE1 . GLU A 1 97  ? 24.238  21.900 -9.730  1.00 15.41 ? 97  GLU C OE1 1 
ATOM   526  O OE2 . GLU A 1 97  ? 22.283  21.980 -8.737  1.00 15.46 ? 97  GLU C OE2 1 
ATOM   527  N N   . LEU A 1 98  ? 20.352  19.899 -14.422 1.00 18.03 ? 98  LEU C N   1 
ATOM   528  C CA  . LEU A 1 98  ? 19.691  20.568 -15.539 1.00 20.05 ? 98  LEU C CA  1 
ATOM   529  C C   . LEU A 1 98  ? 19.035  21.833 -14.997 1.00 21.17 ? 98  LEU C C   1 
ATOM   530  O O   . LEU A 1 98  ? 18.041  21.760 -14.262 1.00 20.80 ? 98  LEU C O   1 
ATOM   531  C CB  . LEU A 1 98  ? 18.673  19.642 -16.201 1.00 21.61 ? 98  LEU C CB  1 
ATOM   532  C CG  . LEU A 1 98  ? 19.207  18.260 -16.566 1.00 21.29 ? 98  LEU C CG  1 
ATOM   533  C CD1 . LEU A 1 98  ? 18.197  17.523 -17.419 1.00 25.07 ? 98  LEU C CD1 1 
ATOM   534  C CD2 . LEU A 1 98  ? 20.564  18.341 -17.268 1.00 22.94 ? 98  LEU C CD2 1 
ATOM   535  N N   . MET A 1 99  ? 19.594  22.991 -15.357 1.00 21.47 ? 99  MET C N   1 
ATOM   536  C CA  . MET A 1 99  ? 19.215  24.262 -14.752 1.00 20.10 ? 99  MET C CA  1 
ATOM   537  C C   . MET A 1 99  ? 18.070  24.957 -15.477 1.00 25.81 ? 99  MET C C   1 
ATOM   538  O O   . MET A 1 99  ? 17.224  25.593 -14.830 1.00 24.36 ? 99  MET C O   1 
ATOM   539  C CB  . MET A 1 99  ? 20.416  25.216 -14.711 1.00 24.58 ? 99  MET C CB  1 
ATOM   540  C CG  . MET A 1 99  ? 21.647  24.669 -14.014 1.00 21.41 ? 99  MET C CG  1 
ATOM   541  S SD  . MET A 1 99  ? 21.278  24.164 -12.318 1.00 20.29 ? 99  MET C SD  1 
ATOM   542  C CE  . MET A 1 99  ? 21.246  25.730 -11.479 1.00 18.61 ? 99  MET C CE  1 
ATOM   543  N N   . TYR A 1 100 ? 18.041  24.860 -16.813 1.00 23.42 ? 100 TYR C N   1 
ATOM   544  C CA  . TYR A 1 100 ? 17.090  25.611 -17.620 1.00 29.02 ? 100 TYR C CA  1 
ATOM   545  C C   . TYR A 1 100 ? 17.096  25.047 -19.035 1.00 30.73 ? 100 TYR C C   1 
ATOM   546  O O   . TYR A 1 100 ? 18.166  24.668 -19.526 1.00 31.79 ? 100 TYR C O   1 
ATOM   547  C CB  . TYR A 1 100 ? 17.427  27.114 -17.631 1.00 28.95 ? 100 TYR C CB  1 
ATOM   548  C CG  . TYR A 1 100 ? 17.002  27.863 -18.889 1.00 35.51 ? 100 TYR C CG  1 
ATOM   549  C CD1 . TYR A 1 100 ? 15.745  28.458 -18.984 1.00 37.37 ? 100 TYR C CD1 1 
ATOM   550  C CD2 . TYR A 1 100 ? 17.870  27.983 -19.983 1.00 36.59 ? 100 TYR C CD2 1 
ATOM   551  C CE1 . TYR A 1 100 ? 15.355  29.138 -20.141 1.00 37.49 ? 100 TYR C CE1 1 
ATOM   552  C CE2 . TYR A 1 100 ? 17.489  28.663 -21.142 1.00 39.36 ? 100 TYR C CE2 1 
ATOM   553  C CZ  . TYR A 1 100 ? 16.227  29.238 -21.214 1.00 41.37 ? 100 TYR C CZ  1 
ATOM   554  O OH  . TYR A 1 100 ? 15.834  29.921 -22.352 1.00 42.46 ? 100 TYR C OH  1 
ATOM   555  N N   . PRO A 1 101 ? 15.939  24.951 -19.692 1.00 34.26 ? 101 PRO C N   1 
ATOM   556  C CA  . PRO A 1 101 ? 14.598  25.326 -19.225 1.00 33.81 ? 101 PRO C CA  1 
ATOM   557  C C   . PRO A 1 101 ? 14.110  24.398 -18.116 1.00 30.79 ? 101 PRO C C   1 
ATOM   558  O O   . PRO A 1 101 ? 14.589  23.272 -17.989 1.00 33.75 ? 101 PRO C O   1 
ATOM   559  C CB  . PRO A 1 101 ? 13.754  25.206 -20.498 1.00 32.69 ? 101 PRO C CB  1 
ATOM   560  C CG  . PRO A 1 101 ? 14.421  24.098 -21.269 1.00 38.52 ? 101 PRO C CG  1 
ATOM   561  C CD  . PRO A 1 101 ? 15.898  24.304 -21.019 1.00 35.58 ? 101 PRO C CD  1 
ATOM   562  N N   . PRO A 1 102 ? 13.180  24.861 -17.289 1.00 31.36 ? 102 PRO C N   1 
ATOM   563  C CA  . PRO A 1 102 ? 12.630  24.009 -16.228 1.00 28.07 ? 102 PRO C CA  1 
ATOM   564  C C   . PRO A 1 102 ? 11.948  22.783 -16.808 1.00 31.85 ? 102 PRO C C   1 
ATOM   565  O O   . PRO A 1 102 ? 11.630  22.746 -18.008 1.00 32.57 ? 102 PRO C O   1 
ATOM   566  C CB  . PRO A 1 102 ? 11.626  24.933 -15.520 1.00 28.13 ? 102 PRO C CB  1 
ATOM   567  C CG  . PRO A 1 102 ? 11.380  26.059 -16.474 1.00 30.64 ? 102 PRO C CG  1 
ATOM   568  C CD  . PRO A 1 102 ? 12.647  26.230 -17.233 1.00 33.11 ? 102 PRO C CD  1 
ATOM   569  N N   . PRO A 1 103 ? 11.720  21.737 -15.992 1.00 29.37 ? 103 PRO C N   1 
ATOM   570  C CA  . PRO A 1 103 ? 12.057  21.609 -14.567 1.00 23.11 ? 103 PRO C CA  1 
ATOM   571  C C   . PRO A 1 103 ? 13.551  21.543 -14.301 1.00 23.49 ? 103 PRO C C   1 
ATOM   572  O O   . PRO A 1 103 ? 14.348  21.065 -15.113 1.00 21.85 ? 103 PRO C O   1 
ATOM   573  C CB  . PRO A 1 103 ? 11.395  20.277 -14.164 1.00 23.54 ? 103 PRO C CB  1 
ATOM   574  C CG  . PRO A 1 103 ? 10.388  19.982 -15.247 1.00 27.61 ? 103 PRO C CG  1 
ATOM   575  C CD  . PRO A 1 103 ? 11.015  20.544 -16.485 1.00 26.03 ? 103 PRO C CD  1 
ATOM   576  N N   . TYR A 1 104 ? 13.952  22.031 -13.137 1.00 20.00 ? 104 TYR C N   1 
ATOM   577  C CA  . TYR A 1 104 ? 15.255  21.677 -12.598 1.00 20.14 ? 104 TYR C CA  1 
ATOM   578  C C   . TYR A 1 104 ? 15.313  20.180 -12.341 1.00 17.70 ? 104 TYR C C   1 
ATOM   579  O O   . TYR A 1 104 ? 14.364  19.605 -11.813 1.00 18.19 ? 104 TYR C O   1 
ATOM   580  C CB  . TYR A 1 104 ? 15.481  22.444 -11.300 1.00 16.09 ? 104 TYR C CB  1 
ATOM   581  C CG  . TYR A 1 104 ? 16.662  22.005 -10.478 1.00 17.64 ? 104 TYR C CG  1 
ATOM   582  C CD1 . TYR A 1 104 ? 16.523  21.075 -9.461  1.00 16.40 ? 104 TYR C CD1 1 
ATOM   583  C CD2 . TYR A 1 104 ? 17.914  22.558 -10.696 1.00 17.57 ? 104 TYR C CD2 1 
ATOM   584  C CE1 . TYR A 1 104 ? 17.617  20.700 -8.697  1.00 16.49 ? 104 TYR C CE1 1 
ATOM   585  C CE2 . TYR A 1 104 ? 18.998  22.192 -9.950  1.00 16.18 ? 104 TYR C CE2 1 
ATOM   586  C CZ  . TYR A 1 104 ? 18.850  21.273 -8.953  1.00 15.38 ? 104 TYR C CZ  1 
ATOM   587  O OH  . TYR A 1 104 ? 19.945  20.924 -8.206  1.00 15.79 ? 104 TYR C OH  1 
ATOM   588  N N   . TYR A 1 105 ? 16.423  19.544 -12.735 1.00 17.97 ? 105 TYR C N   1 
ATOM   589  C CA  . TYR A 1 105 ? 16.717  18.157 -12.378 1.00 17.86 ? 105 TYR C CA  1 
ATOM   590  C C   . TYR A 1 105 ? 18.067  18.080 -11.696 1.00 17.60 ? 105 TYR C C   1 
ATOM   591  O O   . TYR A 1 105 ? 19.017  18.750 -12.111 1.00 17.31 ? 105 TYR C O   1 
ATOM   592  C CB  . TYR A 1 105 ? 16.762  17.210 -13.578 1.00 20.51 ? 105 TYR C CB  1 
ATOM   593  C CG  . TYR A 1 105 ? 15.433  16.986 -14.235 1.00 20.51 ? 105 TYR C CG  1 
ATOM   594  C CD1 . TYR A 1 105 ? 14.959  17.878 -15.169 1.00 20.30 ? 105 TYR C CD1 1 
ATOM   595  C CD2 . TYR A 1 105 ? 14.657  15.878 -13.924 1.00 21.68 ? 105 TYR C CD2 1 
ATOM   596  C CE1 . TYR A 1 105 ? 13.742  17.687 -15.782 1.00 21.76 ? 105 TYR C CE1 1 
ATOM   597  C CE2 . TYR A 1 105 ? 13.427  15.674 -14.526 1.00 20.94 ? 105 TYR C CE2 1 
ATOM   598  C CZ  . TYR A 1 105 ? 12.984  16.585 -15.462 1.00 24.33 ? 105 TYR C CZ  1 
ATOM   599  O OH  . TYR A 1 105 ? 11.773  16.423 -16.081 1.00 24.81 ? 105 TYR C OH  1 
ATOM   600  N N   . LEU A 1 106 ? 18.148  17.237 -10.672 1.00 15.93 ? 106 LEU C N   1 
ATOM   601  C CA  . LEU A 1 106 ? 19.387  16.963 -9.964  1.00 15.92 ? 106 LEU C CA  1 
ATOM   602  C C   . LEU A 1 106 ? 19.707  15.484 -10.100 1.00 17.84 ? 106 LEU C C   1 
ATOM   603  O O   . LEU A 1 106 ? 18.834  14.635 -9.899  1.00 19.40 ? 106 LEU C O   1 
ATOM   604  C CB  . LEU A 1 106 ? 19.278  17.348 -8.490  1.00 16.30 ? 106 LEU C CB  1 
ATOM   605  C CG  . LEU A 1 106 ? 20.392  16.817 -7.593  1.00 15.84 ? 106 LEU C CG  1 
ATOM   606  C CD1 . LEU A 1 106 ? 21.701  17.562 -7.853  1.00 15.37 ? 106 LEU C CD1 1 
ATOM   607  C CD2 . LEU A 1 106 ? 19.984  16.911 -6.114  1.00 15.39 ? 106 LEU C CD2 1 
ATOM   608  N N   . GLY A 1 107 ? 20.944  15.182 -10.436 1.00 17.34 ? 107 GLY C N   1 
ATOM   609  C CA  . GLY A 1 107 ? 21.423  13.809 -10.426 1.00 17.90 ? 107 GLY C CA  1 
ATOM   610  C C   . GLY A 1 107 ? 22.743  13.743 -9.694  1.00 19.04 ? 107 GLY C C   1 
ATOM   611  O O   . GLY A 1 107 ? 23.605  14.602 -9.869  1.00 21.20 ? 107 GLY C O   1 
ATOM   612  N N   . ILE A 1 108 ? 22.877  12.732 -8.838  1.00 19.75 ? 108 ILE C N   1 
ATOM   613  C CA  . ILE A 1 108 ? 24.056  12.558 -7.998  1.00 18.21 ? 108 ILE C CA  1 
ATOM   614  C C   . ILE A 1 108 ? 24.533  11.127 -8.179  1.00 24.99 ? 108 ILE C C   1 
ATOM   615  O O   . ILE A 1 108 ? 23.778  10.178 -7.925  1.00 19.48 ? 108 ILE C O   1 
ATOM   616  C CB  . ILE A 1 108 ? 23.754  12.862 -6.519  1.00 19.48 ? 108 ILE C CB  1 
ATOM   617  C CG1 . ILE A 1 108 ? 23.314  14.321 -6.377  1.00 19.87 ? 108 ILE C CG1 1 
ATOM   618  C CG2 . ILE A 1 108 ? 24.943  12.535 -5.626  1.00 23.87 ? 108 ILE C CG2 1 
ATOM   619  C CD1 . ILE A 1 108 ? 23.580  14.877 -5.050  1.00 18.96 ? 108 ILE C CD1 1 
ATOM   620  N N   . GLY A 1 109 ? 25.766  10.972 -8.656  1.00 21.89 ? 109 GLY C N   1 
ATOM   621  C CA  . GLY A 1 109 ? 26.298  9.648  -8.891  1.00 22.67 ? 109 GLY C CA  1 
ATOM   622  C C   . GLY A 1 109 ? 26.659  8.943  -7.602  1.00 24.96 ? 109 GLY C C   1 
ATOM   623  O O   . GLY A 1 109 ? 26.915  9.566  -6.570  1.00 22.00 ? 109 GLY C O   1 
ATOM   624  N N   . ASN A 1 110 ? 26.699  7.604  -7.680  1.00 26.89 ? 110 ASN C N   1 
ATOM   625  C CA  . ASN A 1 110 ? 27.097  6.791  -6.535  1.00 29.17 ? 110 ASN C CA  1 
ATOM   626  C C   . ASN A 1 110 ? 28.526  7.068  -6.088  1.00 30.88 ? 110 ASN C C   1 
ATOM   627  O O   . ASN A 1 110 ? 28.922  6.629  -5.002  1.00 34.02 ? 110 ASN C O   1 
ATOM   628  C CB  . ASN A 1 110 ? 26.934  5.303  -6.861  1.00 29.92 ? 110 ASN C CB  1 
ATOM   629  C CG  . ASN A 1 110 ? 25.597  4.743  -6.386  1.00 33.23 ? 110 ASN C CG  1 
ATOM   630  O OD1 . ASN A 1 110 ? 24.780  5.463  -5.809  1.00 32.91 ? 110 ASN C OD1 1 
ATOM   631  N ND2 . ASN A 1 110 ? 25.370  3.454  -6.626  1.00 38.61 ? 110 ASN C ND2 1 
ATOM   632  N N   . GLY A 1 111 ? 29.302  7.775  -6.883  1.00 28.89 ? 111 GLY C N   1 
ATOM   633  C CA  . GLY A 1 111 ? 30.632  8.131  -6.449  1.00 30.25 ? 111 GLY C CA  1 
ATOM   634  C C   . GLY A 1 111 ? 31.676  7.248  -7.099  1.00 35.87 ? 111 GLY C C   1 
ATOM   635  O O   . GLY A 1 111 ? 31.429  6.080  -7.429  1.00 37.65 ? 111 GLY C O   1 
ATOM   636  N N   . THR A 1 112 ? 32.861  7.816  -7.299  1.00 33.97 ? 112 THR C N   1 
ATOM   637  C CA  . THR A 1 112 ? 33.977  7.109  -7.908  1.00 34.61 ? 112 THR C CA  1 
ATOM   638  C C   . THR A 1 112 ? 35.104  7.035  -6.897  1.00 35.96 ? 112 THR C C   1 
ATOM   639  O O   . THR A 1 112 ? 35.519  8.059  -6.342  1.00 34.64 ? 112 THR C O   1 
ATOM   640  C CB  . THR A 1 112 ? 34.446  7.788  -9.195  1.00 35.10 ? 112 THR C CB  1 
ATOM   641  O OG1 . THR A 1 112 ? 33.557  7.441  -10.267 1.00 32.75 ? 112 THR C OG1 1 
ATOM   642  C CG2 . THR A 1 112 ? 35.855  7.325  -9.558  1.00 39.54 ? 112 THR C CG2 1 
ATOM   643  N N   . GLN A 1 113 ? 35.568  5.820  -6.633  1.00 38.62 ? 113 GLN C N   1 
ATOM   644  C CA  . GLN A 1 113 ? 36.758  5.620  -5.823  1.00 40.34 ? 113 GLN C CA  1 
ATOM   645  C C   . GLN A 1 113 ? 37.979  5.718  -6.727  1.00 41.43 ? 113 GLN C C   1 
ATOM   646  O O   . GLN A 1 113 ? 38.069  5.008  -7.736  1.00 39.54 ? 113 GLN C O   1 
ATOM   647  C CB  . GLN A 1 113 ? 36.708  4.263  -5.127  1.00 43.00 ? 113 GLN C CB  1 
ATOM   648  C CG  . GLN A 1 113 ? 37.865  4.004  -4.183  1.00 44.37 ? 113 GLN C CG  1 
ATOM   649  C CD  . GLN A 1 113 ? 37.618  4.563  -2.803  1.00 46.06 ? 113 GLN C CD  1 
ATOM   650  O OE1 . GLN A 1 113 ? 36.943  5.577  -2.647  1.00 42.52 ? 113 GLN C OE1 1 
ATOM   651  N NE2 . GLN A 1 113 ? 38.153  3.893  -1.785  1.00 50.29 ? 113 GLN C NE2 1 
ATOM   652  N N   . ILE A 1 114 ? 38.899  6.619  -6.392  1.00 42.88 ? 114 ILE C N   1 
ATOM   653  C CA  . ILE A 1 114 ? 40.147  6.778  -7.130  1.00 43.35 ? 114 ILE C CA  1 
ATOM   654  C C   . ILE A 1 114 ? 41.280  6.311  -6.230  1.00 44.68 ? 114 ILE C C   1 
ATOM   655  O O   . ILE A 1 114 ? 41.334  6.670  -5.046  1.00 47.61 ? 114 ILE C O   1 
ATOM   656  C CB  . ILE A 1 114 ? 40.365  8.227  -7.607  1.00 43.90 ? 114 ILE C CB  1 
ATOM   657  C CG1 . ILE A 1 114 ? 40.486  9.183  -6.429  1.00 46.22 ? 114 ILE C CG1 1 
ATOM   658  C CG2 . ILE A 1 114 ? 39.229  8.691  -8.510  1.00 41.13 ? 114 ILE C CG2 1 
ATOM   659  C CD1 . ILE A 1 114 ? 41.883  9.690  -6.189  1.00 47.70 ? 114 ILE C CD1 1 
ATOM   660  N N   . TYR A 1 115 ? 42.165  5.486  -6.782  1.00 46.64 ? 115 TYR C N   1 
ATOM   661  C CA  . TYR A 1 115 ? 43.308  4.941  -6.059  1.00 45.58 ? 115 TYR C CA  1 
ATOM   662  C C   . TYR A 1 115 ? 44.578  5.551  -6.635  1.00 46.44 ? 115 TYR C C   1 
ATOM   663  O O   . TYR A 1 115 ? 44.929  5.288  -7.791  1.00 45.15 ? 115 TYR C O   1 
ATOM   664  C CB  . TYR A 1 115 ? 43.339  3.418  -6.156  1.00 44.90 ? 115 TYR C CB  1 
ATOM   665  C CG  . TYR A 1 115 ? 42.258  2.737  -5.351  1.00 46.20 ? 115 TYR C CG  1 
ATOM   666  C CD1 . TYR A 1 115 ? 42.345  2.657  -3.967  1.00 47.06 ? 115 TYR C CD1 1 
ATOM   667  C CD2 . TYR A 1 115 ? 41.154  2.168  -5.972  1.00 46.92 ? 115 TYR C CD2 1 
ATOM   668  C CE1 . TYR A 1 115 ? 41.359  2.033  -3.220  1.00 47.92 ? 115 TYR C CE1 1 
ATOM   669  C CE2 . TYR A 1 115 ? 40.161  1.538  -5.231  1.00 48.53 ? 115 TYR C CE2 1 
ATOM   670  C CZ  . TYR A 1 115 ? 40.270  1.475  -3.855  1.00 48.22 ? 115 TYR C CZ  1 
ATOM   671  O OH  . TYR A 1 115 ? 39.289  0.853  -3.111  1.00 46.46 ? 115 TYR C OH  1 
ATOM   672  N N   . VAL A 1 116 ? 45.251  6.376  -5.837  1.00 49.60 ? 116 VAL C N   1 
ATOM   673  C CA  . VAL A 1 116 ? 46.548  6.942  -6.192  1.00 48.67 ? 116 VAL C CA  1 
ATOM   674  C C   . VAL A 1 116 ? 47.609  6.158  -5.432  1.00 47.75 ? 116 VAL C C   1 
ATOM   675  O O   . VAL A 1 116 ? 47.598  6.121  -4.195  1.00 49.09 ? 116 VAL C O   1 
ATOM   676  C CB  . VAL A 1 116 ? 46.622  8.443  -5.864  1.00 50.59 ? 116 VAL C CB  1 
ATOM   677  C CG1 . VAL A 1 116 ? 47.768  9.104  -6.618  1.00 49.19 ? 116 VAL C CG1 1 
ATOM   678  C CG2 . VAL A 1 116 ? 45.315  9.123  -6.195  1.00 47.31 ? 116 VAL C CG2 1 
ATOM   679  N N   . ILE A 1 117 ? 48.510  5.515  -6.162  1.00 48.70 ? 117 ILE C N   1 
ATOM   680  C CA  . ILE A 1 117 ? 49.594  4.771  -5.535  1.00 50.25 ? 117 ILE C CA  1 
ATOM   681  C C   . ILE A 1 117 ? 50.837  4.840  -6.414  1.00 51.01 ? 117 ILE C C   1 
ATOM   682  O O   . ILE A 1 117 ? 51.347  5.926  -6.700  1.00 50.35 ? 117 ILE C O   1 
ATOM   683  C CB  . ILE A 1 117 ? 49.186  3.307  -5.256  1.00 44.39 ? 117 ILE C CB  1 
ATOM   684  N N   . GLN B 2 1   ? 28.435  27.468 12.032  1.00 35.48 ? 1   GLN H N   1 
ATOM   685  C CA  . GLN B 2 1   ? 27.051  27.575 12.495  1.00 29.91 ? 1   GLN H CA  1 
ATOM   686  C C   . GLN B 2 1   ? 26.149  28.328 11.497  1.00 23.94 ? 1   GLN H C   1 
ATOM   687  O O   . GLN B 2 1   ? 26.120  29.550 11.436  1.00 24.07 ? 1   GLN H O   1 
ATOM   688  C CB  . GLN B 2 1   ? 27.023  28.257 13.869  1.00 35.55 ? 1   GLN H CB  1 
ATOM   689  C CG  . GLN B 2 1   ? 27.820  29.546 13.927  1.00 37.44 ? 1   GLN H CG  1 
ATOM   690  C CD  . GLN B 2 1   ? 27.512  30.347 15.172  1.00 42.77 ? 1   GLN H CD  1 
ATOM   691  O OE1 . GLN B 2 1   ? 27.223  29.784 16.231  1.00 46.30 ? 1   GLN H OE1 1 
ATOM   692  N NE2 . GLN B 2 1   ? 27.576  31.671 15.055  1.00 33.71 ? 1   GLN H NE2 1 
ATOM   693  N N   . VAL B 2 2   ? 25.403  27.562 10.708  1.00 23.44 ? 2   VAL H N   1 
ATOM   694  C CA  . VAL B 2 2   ? 24.502  28.136 9.711   1.00 19.22 ? 2   VAL H CA  1 
ATOM   695  C C   . VAL B 2 2   ? 23.338  28.834 10.406  1.00 21.17 ? 2   VAL H C   1 
ATOM   696  O O   . VAL B 2 2   ? 22.781  28.318 11.380  1.00 21.16 ? 2   VAL H O   1 
ATOM   697  C CB  . VAL B 2 2   ? 24.011  27.027 8.769   1.00 19.43 ? 2   VAL H CB  1 
ATOM   698  C CG1 . VAL B 2 2   ? 23.064  27.589 7.694   1.00 21.29 ? 2   VAL H CG1 1 
ATOM   699  C CG2 . VAL B 2 2   ? 25.213  26.311 8.137   1.00 20.41 ? 2   VAL H CG2 1 
ATOM   700  N N   . GLN B 2 3   ? 22.984  30.031 9.932   1.00 19.43 ? 3   GLN H N   1 
ATOM   701  C CA  . GLN B 2 3   ? 21.808  30.742 10.414  1.00 19.50 ? 3   GLN H CA  1 
ATOM   702  C C   . GLN B 2 3   ? 21.009  31.314 9.247   1.00 17.98 ? 3   GLN H C   1 
ATOM   703  O O   . GLN B 2 3   ? 21.572  31.864 8.298   1.00 13.91 ? 3   GLN H O   1 
ATOM   704  C CB  . GLN B 2 3   ? 22.168  31.882 11.387  1.00 23.01 ? 3   GLN H CB  1 
ATOM   705  C CG  . GLN B 2 3   ? 22.696  31.432 12.761  1.00 29.69 ? 3   GLN H CG  1 
ATOM   706  C CD  . GLN B 2 3   ? 21.647  30.723 13.623  1.00 33.91 ? 3   GLN H CD  1 
ATOM   707  O OE1 . GLN B 2 3   ? 20.442  30.973 13.504  1.00 40.16 ? 3   GLN H OE1 1 
ATOM   708  N NE2 . GLN B 2 3   ? 22.111  29.837 14.503  1.00 35.34 ? 3   GLN H NE2 1 
ATOM   709  N N   . LEU B 2 4   ? 19.686  31.196 9.348   1.00 14.35 ? 4   LEU H N   1 
ATOM   710  C CA  . LEU B 2 4   ? 18.740  31.762 8.391   1.00 16.63 ? 4   LEU H CA  1 
ATOM   711  C C   . LEU B 2 4   ? 17.642  32.438 9.198   1.00 15.79 ? 4   LEU H C   1 
ATOM   712  O O   . LEU B 2 4   ? 16.979  31.779 10.008  1.00 15.47 ? 4   LEU H O   1 
ATOM   713  C CB  . LEU B 2 4   ? 18.139  30.672 7.500   1.00 14.27 ? 4   LEU H CB  1 
ATOM   714  C CG  . LEU B 2 4   ? 19.108  29.811 6.708   1.00 12.72 ? 4   LEU H CG  1 
ATOM   715  C CD1 . LEU B 2 4   ? 18.369  28.598 6.135   1.00 12.09 ? 4   LEU H CD1 1 
ATOM   716  C CD2 . LEU B 2 4   ? 19.737  30.634 5.595   1.00 14.11 ? 4   LEU H CD2 1 
ATOM   717  N N   . VAL B 2 5   ? 17.447  33.739 9.011   1.00 13.73 ? 5   VAL H N   1 
ATOM   718  C CA  . VAL B 2 5   ? 16.457  34.473 9.813   1.00 16.48 ? 5   VAL H CA  1 
ATOM   719  C C   . VAL B 2 5   ? 15.490  35.203 8.877   1.00 15.36 ? 5   VAL H C   1 
ATOM   720  O O   . VAL B 2 5   ? 15.870  36.145 8.169   1.00 16.53 ? 5   VAL H O   1 
ATOM   721  C CB  . VAL B 2 5   ? 17.100  35.438 10.832  1.00 21.24 ? 5   VAL H CB  1 
ATOM   722  C CG1 . VAL B 2 5   ? 18.028  34.670 11.767  1.00 21.82 ? 5   VAL H CG1 1 
ATOM   723  C CG2 . VAL B 2 5   ? 17.866  36.547 10.174  1.00 26.38 ? 5   VAL H CG2 1 
ATOM   724  N N   . GLU B 2 6   ? 14.241  34.763 8.872   1.00 14.95 ? 6   GLU H N   1 
ATOM   725  C CA  . GLU B 2 6   ? 13.235  35.397 8.043   1.00 15.24 ? 6   GLU H CA  1 
ATOM   726  C C   . GLU B 2 6   ? 12.654  36.602 8.763   1.00 15.82 ? 6   GLU H C   1 
ATOM   727  O O   . GLU B 2 6   ? 12.588  36.647 9.994   1.00 17.03 ? 6   GLU H O   1 
ATOM   728  C CB  . GLU B 2 6   ? 12.127  34.411 7.687   1.00 14.62 ? 6   GLU H CB  1 
ATOM   729  C CG  . GLU B 2 6   ? 12.635  33.125 7.054   1.00 12.66 ? 6   GLU H CG  1 
ATOM   730  C CD  . GLU B 2 6   ? 12.824  32.014 8.055   1.00 13.43 ? 6   GLU H CD  1 
ATOM   731  O OE1 . GLU B 2 6   ? 13.066  32.336 9.236   1.00 17.32 ? 6   GLU H OE1 1 
ATOM   732  O OE2 . GLU B 2 6   ? 12.753  30.824 7.663   1.00 13.45 ? 6   GLU H OE2 1 
ATOM   733  N N   . SER B 2 7   ? 12.254  37.598 7.979   1.00 16.78 ? 7   SER H N   1 
ATOM   734  C CA  . SER B 2 7   ? 11.535  38.738 8.517   1.00 15.75 ? 7   SER H CA  1 
ATOM   735  C C   . SER B 2 7   ? 10.577  39.279 7.464   1.00 15.84 ? 7   SER H C   1 
ATOM   736  O O   . SER B 2 7   ? 10.667  38.952 6.274   1.00 14.12 ? 7   SER H O   1 
ATOM   737  C CB  . SER B 2 7   ? 12.494  39.823 8.988   1.00 14.57 ? 7   SER H CB  1 
ATOM   738  O OG  . SER B 2 7   ? 13.265  40.278 7.900   1.00 19.08 ? 7   SER H OG  1 
ATOM   739  N N   . GLY B 2 8   ? 9.646   40.110 7.920   1.00 14.95 ? 8   GLY H N   1 
ATOM   740  C CA  . GLY B 2 8   ? 8.728   40.801 7.033   1.00 15.92 ? 8   GLY H CA  1 
ATOM   741  C C   . GLY B 2 8   ? 7.290   40.352 7.138   1.00 18.54 ? 8   GLY H C   1 
ATOM   742  O O   . GLY B 2 8   ? 6.412   41.009 6.559   1.00 18.50 ? 8   GLY H O   1 
ATOM   743  N N   . GLY B 2 9   ? 7.012   39.272 7.864   1.00 15.82 ? 9   GLY H N   1 
ATOM   744  C CA  . GLY B 2 9   ? 5.652   38.809 7.997   1.00 14.55 ? 9   GLY H CA  1 
ATOM   745  C C   . GLY B 2 9   ? 4.777   39.759 8.794   1.00 16.74 ? 9   GLY H C   1 
ATOM   746  O O   . GLY B 2 9   ? 5.235   40.648 9.515   1.00 19.32 ? 9   GLY H O   1 
ATOM   747  N N   . GLY B 2 10  ? 3.482   39.582 8.625   1.00 17.33 ? 10  GLY H N   1 
ATOM   748  C CA  . GLY B 2 10  ? 2.517   40.382 9.347   1.00 16.81 ? 10  GLY H CA  1 
ATOM   749  C C   . GLY B 2 10  ? 1.166   40.248 8.681   1.00 19.85 ? 10  GLY H C   1 
ATOM   750  O O   . GLY B 2 10  ? 0.967   39.403 7.812   1.00 17.49 ? 10  GLY H O   1 
ATOM   751  N N   . VAL B 2 11  ? 0.257   41.127 9.080   1.00 17.81 ? 11  VAL H N   1 
ATOM   752  C CA  . VAL B 2 11  ? -1.089  41.147 8.523   1.00 20.30 ? 11  VAL H CA  1 
ATOM   753  C C   . VAL B 2 11  ? -1.089  41.993 7.254   1.00 20.64 ? 11  VAL H C   1 
ATOM   754  O O   . VAL B 2 11  ? -0.567  43.119 7.242   1.00 18.61 ? 11  VAL H O   1 
ATOM   755  C CB  . VAL B 2 11  ? -2.102  41.680 9.551   1.00 19.83 ? 11  VAL H CB  1 
ATOM   756  C CG1 . VAL B 2 11  ? -3.496  41.675 8.963   1.00 15.43 ? 11  VAL H CG1 1 
ATOM   757  C CG2 . VAL B 2 11  ? -2.047  40.861 10.835  1.00 19.11 ? 11  VAL H CG2 1 
ATOM   758  N N   . VAL B 2 12  ? -1.658  41.439 6.178   1.00 17.25 ? 12  VAL H N   1 
ATOM   759  C CA  . VAL B 2 12  ? -1.753  42.092 4.876   1.00 18.53 ? 12  VAL H CA  1 
ATOM   760  C C   . VAL B 2 12  ? -3.171  41.928 4.354   1.00 17.84 ? 12  VAL H C   1 
ATOM   761  O O   . VAL B 2 12  ? -3.756  40.843 4.458   1.00 16.58 ? 12  VAL H O   1 
ATOM   762  C CB  . VAL B 2 12  ? -0.777  41.498 3.843   1.00 22.73 ? 12  VAL H CB  1 
ATOM   763  C CG1 . VAL B 2 12  ? -0.366  42.548 2.804   1.00 20.92 ? 12  VAL H CG1 1 
ATOM   764  C CG2 . VAL B 2 12  ? 0.391   40.851 4.515   1.00 26.12 ? 12  VAL H CG2 1 
ATOM   765  N N   . GLN B 2 13  ? -3.695  42.982 3.730   1.00 17.30 ? 13  GLN H N   1 
ATOM   766  C CA  . GLN B 2 13  ? -5.027  42.956 3.152   1.00 17.94 ? 13  GLN H CA  1 
ATOM   767  C C   . GLN B 2 13  ? -5.027  42.225 1.809   1.00 19.96 ? 13  GLN H C   1 
ATOM   768  O O   . GLN B 2 13  ? -4.058  42.302 1.050   1.00 20.96 ? 13  GLN H O   1 
ATOM   769  C CB  . GLN B 2 13  ? -5.559  44.381 2.968   1.00 20.54 ? 13  GLN H CB  1 
ATOM   770  C CG  . GLN B 2 13  ? -5.464  45.219 4.239   1.00 25.23 ? 13  GLN H CG  1 
ATOM   771  C CD  . GLN B 2 13  ? -6.808  45.666 4.780   1.00 26.87 ? 13  GLN H CD  1 
ATOM   772  O OE1 . GLN B 2 13  ? -7.853  45.108 4.445   1.00 26.62 ? 13  GLN H OE1 1 
ATOM   773  N NE2 . GLN B 2 13  ? -6.784  46.690 5.628   1.00 32.07 ? 13  GLN H NE2 1 
ATOM   774  N N   . PRO B 2 14  ? -6.109  41.517 1.500   1.00 18.42 ? 14  PRO H N   1 
ATOM   775  C CA  . PRO B 2 14  ? -6.165  40.751 0.250   1.00 22.18 ? 14  PRO H CA  1 
ATOM   776  C C   . PRO B 2 14  ? -5.923  41.653 -0.946  1.00 21.77 ? 14  PRO H C   1 
ATOM   777  O O   . PRO B 2 14  ? -6.261  42.839 -0.935  1.00 21.15 ? 14  PRO H O   1 
ATOM   778  C CB  . PRO B 2 14  ? -7.591  40.184 0.238   1.00 23.40 ? 14  PRO H CB  1 
ATOM   779  C CG  . PRO B 2 14  ? -8.092  40.310 1.629   1.00 23.01 ? 14  PRO H CG  1 
ATOM   780  C CD  . PRO B 2 14  ? -7.390  41.488 2.230   1.00 20.52 ? 14  PRO H CD  1 
ATOM   781  N N   . GLY B 2 15  ? -5.325  41.073 -1.987  1.00 22.20 ? 15  GLY H N   1 
ATOM   782  C CA  . GLY B 2 15  ? -4.974  41.808 -3.182  1.00 21.83 ? 15  GLY H CA  1 
ATOM   783  C C   . GLY B 2 15  ? -3.703  42.620 -3.089  1.00 25.68 ? 15  GLY H C   1 
ATOM   784  O O   . GLY B 2 15  ? -3.149  42.988 -4.136  1.00 23.61 ? 15  GLY H O   1 
ATOM   785  N N   . ARG B 2 16  ? -3.209  42.903 -1.878  1.00 21.84 ? 16  ARG H N   1 
ATOM   786  C CA  . ARG B 2 16  ? -2.056  43.773 -1.690  1.00 23.17 ? 16  ARG H CA  1 
ATOM   787  C C   . ARG B 2 16  ? -0.761  42.962 -1.786  1.00 21.12 ? 16  ARG H C   1 
ATOM   788  O O   . ARG B 2 16  ? -0.755  41.812 -2.241  1.00 21.23 ? 16  ARG H O   1 
ATOM   789  C CB  . ARG B 2 16  ? -2.173  44.518 -0.363  1.00 22.88 ? 16  ARG H CB  1 
ATOM   790  C CG  . ARG B 2 16  ? -3.338  45.479 -0.305  1.00 24.86 ? 16  ARG H CG  1 
ATOM   791  C CD  . ARG B 2 16  ? -3.066  46.708 -1.173  1.00 35.93 ? 16  ARG H CD  1 
ATOM   792  N NE  . ARG B 2 16  ? -2.080  47.608 -0.579  1.00 45.36 ? 16  ARG H NE  1 
ATOM   793  C CZ  . ARG B 2 16  ? -1.566  48.675 -1.183  1.00 43.52 ? 16  ARG H CZ  1 
ATOM   794  N NH1 . ARG B 2 16  ? -1.892  48.993 -2.428  1.00 45.90 ? 16  ARG H NH1 1 
ATOM   795  N NH2 . ARG B 2 16  ? -0.700  49.440 -0.521  1.00 44.39 ? 16  ARG H NH2 1 
ATOM   796  N N   . SER B 2 17  ? 0.351   43.555 -1.350  1.00 21.35 ? 17  SER H N   1 
ATOM   797  C CA  . SER B 2 17  ? 1.668   42.971 -1.557  1.00 21.00 ? 17  SER H CA  1 
ATOM   798  C C   . SER B 2 17  ? 2.505   43.105 -0.292  1.00 20.20 ? 17  SER H C   1 
ATOM   799  O O   . SER B 2 17  ? 2.251   43.952 0.564   1.00 20.33 ? 17  SER H O   1 
ATOM   800  C CB  . SER B 2 17  ? 2.396   43.616 -2.754  1.00 23.69 ? 17  SER H CB  1 
ATOM   801  O OG  . SER B 2 17  ? 2.825   44.927 -2.432  1.00 33.54 ? 17  SER H OG  1 
ATOM   802  N N   . LEU B 2 18  ? 3.508   42.233 -0.185  1.00 21.10 ? 18  LEU H N   1 
ATOM   803  C CA  . LEU B 2 18  ? 4.361   42.120 0.989   1.00 17.74 ? 18  LEU H CA  1 
ATOM   804  C C   . LEU B 2 18  ? 5.687   41.518 0.544   1.00 16.29 ? 18  LEU H C   1 
ATOM   805  O O   . LEU B 2 18  ? 5.697   40.597 -0.275  1.00 18.28 ? 18  LEU H O   1 
ATOM   806  C CB  . LEU B 2 18  ? 3.704   41.228 2.050   1.00 20.92 ? 18  LEU H CB  1 
ATOM   807  C CG  . LEU B 2 18  ? 4.275   41.243 3.466   1.00 19.82 ? 18  LEU H CG  1 
ATOM   808  C CD1 . LEU B 2 18  ? 3.962   42.565 4.143   1.00 23.13 ? 18  LEU H CD1 1 
ATOM   809  C CD2 . LEU B 2 18  ? 3.745   40.085 4.276   1.00 19.33 ? 18  LEU H CD2 1 
ATOM   810  N N   . ARG B 2 19  ? 6.796   42.021 1.083   1.00 17.13 ? 19  ARG H N   1 
ATOM   811  C CA  . ARG B 2 19  ? 8.113   41.465 0.787   1.00 17.01 ? 19  ARG H CA  1 
ATOM   812  C C   . ARG B 2 19  ? 8.704   40.823 2.033   1.00 13.41 ? 19  ARG H C   1 
ATOM   813  O O   . ARG B 2 19  ? 8.799   41.468 3.081   1.00 16.18 ? 19  ARG H O   1 
ATOM   814  C CB  . ARG B 2 19  ? 9.080   42.526 0.244   1.00 17.80 ? 19  ARG H CB  1 
ATOM   815  C CG  . ARG B 2 19  ? 10.328  41.881 -0.356  1.00 17.81 ? 19  ARG H CG  1 
ATOM   816  C CD  . ARG B 2 19  ? 11.239  42.857 -1.083  1.00 25.13 ? 19  ARG H CD  1 
ATOM   817  N NE  . ARG B 2 19  ? 12.108  43.566 -0.153  1.00 28.06 ? 19  ARG H NE  1 
ATOM   818  C CZ  . ARG B 2 19  ? 13.371  43.885 -0.408  1.00 30.36 ? 19  ARG H CZ  1 
ATOM   819  N NH1 . ARG B 2 19  ? 13.952  43.548 -1.548  1.00 31.13 ? 19  ARG H NH1 1 
ATOM   820  N NH2 . ARG B 2 19  ? 14.069  44.555 0.506   1.00 34.71 ? 19  ARG H NH2 1 
ATOM   821  N N   . LEU B 2 20  ? 9.097   39.553 1.923   1.00 14.16 ? 20  LEU H N   1 
ATOM   822  C CA  . LEU B 2 20  ? 9.831   38.887 2.990   1.00 13.21 ? 20  LEU H CA  1 
ATOM   823  C C   . LEU B 2 20  ? 11.319  38.879 2.677   1.00 12.23 ? 20  LEU H C   1 
ATOM   824  O O   . LEU B 2 20  ? 11.720  38.881 1.512   1.00 14.15 ? 20  LEU H O   1 
ATOM   825  C CB  . LEU B 2 20  ? 9.372   37.442 3.173   1.00 10.56 ? 20  LEU H CB  1 
ATOM   826  C CG  . LEU B 2 20  ? 7.867   37.222 3.293   1.00 11.02 ? 20  LEU H CG  1 
ATOM   827  C CD1 . LEU B 2 20  ? 7.576   35.738 3.528   1.00 10.65 ? 20  LEU H CD1 1 
ATOM   828  C CD2 . LEU B 2 20  ? 7.326   38.090 4.428   1.00 15.05 ? 20  LEU H CD2 1 
ATOM   829  N N   . SER B 2 21  ? 12.131  38.822 3.728   1.00 12.30 ? 21  SER H N   1 
ATOM   830  C CA  . SER B 2 21  ? 13.579  38.718 3.602   1.00 13.31 ? 21  SER H CA  1 
ATOM   831  C C   . SER B 2 21  ? 14.089  37.551 4.423   1.00 13.47 ? 21  SER H C   1 
ATOM   832  O O   . SER B 2 21  ? 13.559  37.265 5.498   1.00 15.30 ? 21  SER H O   1 
ATOM   833  C CB  . SER B 2 21  ? 14.291  39.991 4.070   1.00 14.07 ? 21  SER H CB  1 
ATOM   834  O OG  . SER B 2 21  ? 13.965  41.062 3.209   1.00 25.80 ? 21  SER H OG  1 
ATOM   835  N N   . CYS B 2 22  ? 15.134  36.894 3.920   1.00 14.56 ? 22  CYS H N   1 
ATOM   836  C CA  . CYS B 2 22  ? 15.836  35.869 4.681   1.00 14.91 ? 22  CYS H CA  1 
ATOM   837  C C   . CYS B 2 22  ? 17.315  36.232 4.712   1.00 14.87 ? 22  CYS H C   1 
ATOM   838  O O   . CYS B 2 22  ? 17.989  36.203 3.680   1.00 15.26 ? 22  CYS H O   1 
ATOM   839  C CB  . CYS B 2 22  ? 15.611  34.490 4.077   1.00 15.91 ? 22  CYS H CB  1 
ATOM   840  S SG  . CYS B 2 22  ? 16.624  33.236 4.815   1.00 15.48 ? 22  CYS H SG  1 
ATOM   841  N N   . ALA B 2 23  ? 17.805  36.606 5.884   1.00 15.84 ? 23  ALA H N   1 
ATOM   842  C CA  . ALA B 2 23  ? 19.203  36.967 6.070   1.00 17.54 ? 23  ALA H CA  1 
ATOM   843  C C   . ALA B 2 23  ? 19.989  35.719 6.455   1.00 16.72 ? 23  ALA H C   1 
ATOM   844  O O   . ALA B 2 23  ? 19.712  35.098 7.488   1.00 15.93 ? 23  ALA H O   1 
ATOM   845  C CB  . ALA B 2 23  ? 19.345  38.051 7.134   1.00 19.42 ? 23  ALA H CB  1 
ATOM   846  N N   . ALA B 2 24  ? 20.969  35.358 5.629   1.00 16.28 ? 24  ALA H N   1 
ATOM   847  C CA  . ALA B 2 24  ? 21.756  34.148 5.816   1.00 12.27 ? 24  ALA H CA  1 
ATOM   848  C C   . ALA B 2 24  ? 23.128  34.477 6.385   1.00 17.49 ? 24  ALA H C   1 
ATOM   849  O O   . ALA B 2 24  ? 23.678  35.563 6.157   1.00 17.62 ? 24  ALA H O   1 
ATOM   850  C CB  . ALA B 2 24  ? 21.936  33.401 4.499   1.00 14.67 ? 24  ALA H CB  1 
ATOM   851  N N   . SER B 2 25  ? 23.681  33.523 7.122   1.00 15.73 ? 25  SER H N   1 
ATOM   852  C CA  . SER B 2 25  ? 25.044  33.668 7.621   1.00 17.25 ? 25  SER H CA  1 
ATOM   853  C C   . SER B 2 25  ? 25.597  32.303 8.016   1.00 17.01 ? 25  SER H C   1 
ATOM   854  O O   . SER B 2 25  ? 24.854  31.335 8.190   1.00 14.55 ? 25  SER H O   1 
ATOM   855  C CB  . SER B 2 25  ? 25.101  34.646 8.802   1.00 17.47 ? 25  SER H CB  1 
ATOM   856  O OG  . SER B 2 25  ? 24.267  34.238 9.866   1.00 19.88 ? 25  SER H OG  1 
ATOM   857  N N   . GLY B 2 26  ? 26.924  32.242 8.168   1.00 16.27 ? 26  GLY H N   1 
ATOM   858  C CA  . GLY B 2 26  ? 27.586  31.004 8.536   1.00 16.52 ? 26  GLY H CA  1 
ATOM   859  C C   . GLY B 2 26  ? 27.941  30.074 7.396   1.00 15.27 ? 26  GLY H C   1 
ATOM   860  O O   . GLY B 2 26  ? 28.407  28.952 7.654   1.00 15.70 ? 26  GLY H O   1 
ATOM   861  N N   . PHE B 2 27  ? 27.741  30.488 6.149   1.00 12.74 ? 27  PHE H N   1 
ATOM   862  C CA  . PHE B 2 27  ? 28.078  29.670 4.990   1.00 13.13 ? 27  PHE H CA  1 
ATOM   863  C C   . PHE B 2 27  ? 28.215  30.594 3.787   1.00 13.86 ? 27  PHE H C   1 
ATOM   864  O O   . PHE B 2 27  ? 27.844  31.766 3.843   1.00 14.68 ? 27  PHE H O   1 
ATOM   865  C CB  . PHE B 2 27  ? 27.033  28.565 4.732   1.00 15.51 ? 27  PHE H CB  1 
ATOM   866  C CG  . PHE B 2 27  ? 25.663  29.077 4.338   1.00 12.58 ? 27  PHE H CG  1 
ATOM   867  C CD1 . PHE B 2 27  ? 24.774  29.544 5.295   1.00 12.35 ? 27  PHE H CD1 1 
ATOM   868  C CD2 . PHE B 2 27  ? 25.257  29.063 3.006   1.00 12.26 ? 27  PHE H CD2 1 
ATOM   869  C CE1 . PHE B 2 27  ? 23.512  29.997 4.948   1.00 13.96 ? 27  PHE H CE1 1 
ATOM   870  C CE2 . PHE B 2 27  ? 23.994  29.509 2.651   1.00 13.13 ? 27  PHE H CE2 1 
ATOM   871  C CZ  . PHE B 2 27  ? 23.123  29.984 3.619   1.00 13.16 ? 27  PHE H CZ  1 
ATOM   872  N N   . THR B 2 28  ? 28.786  30.062 2.705   1.00 14.90 ? 28  THR H N   1 
ATOM   873  C CA  . THR B 2 28  ? 28.983  30.859 1.495   1.00 15.48 ? 28  THR H CA  1 
ATOM   874  C C   . THR B 2 28  ? 27.666  30.839 0.722   1.00 14.01 ? 28  THR H C   1 
ATOM   875  O O   . THR B 2 28  ? 27.408  29.917 -0.056  1.00 11.89 ? 28  THR H O   1 
ATOM   876  C CB  . THR B 2 28  ? 30.153  30.327 0.669   1.00 19.12 ? 28  THR H CB  1 
ATOM   877  O OG1 . THR B 2 28  ? 29.831  29.035 0.145   1.00 30.55 ? 28  THR H OG1 1 
ATOM   878  C CG2 . THR B 2 28  ? 31.363  30.170 1.521   1.00 11.61 ? 28  THR H CG2 1 
ATOM   879  N N   . PHE B 2 29  ? 26.861  31.889 0.929   1.00 14.54 ? 29  PHE H N   1 
ATOM   880  C CA  . PHE B 2 29  ? 25.468  31.953 0.476   1.00 13.74 ? 29  PHE H CA  1 
ATOM   881  C C   . PHE B 2 29  ? 25.342  31.654 -1.005  1.00 13.13 ? 29  PHE H C   1 
ATOM   882  O O   . PHE B 2 29  ? 24.446  30.904 -1.435  1.00 12.62 ? 29  PHE H O   1 
ATOM   883  C CB  . PHE B 2 29  ? 24.919  33.354 0.798   1.00 13.20 ? 29  PHE H CB  1 
ATOM   884  C CG  . PHE B 2 29  ? 23.462  33.554 0.442   1.00 13.70 ? 29  PHE H CG  1 
ATOM   885  C CD1 . PHE B 2 29  ? 22.451  32.892 1.140   1.00 15.39 ? 29  PHE H CD1 1 
ATOM   886  C CD2 . PHE B 2 29  ? 23.104  34.453 -0.557  1.00 15.91 ? 29  PHE H CD2 1 
ATOM   887  C CE1 . PHE B 2 29  ? 21.107  33.087 0.814   1.00 13.43 ? 29  PHE H CE1 1 
ATOM   888  C CE2 . PHE B 2 29  ? 21.761  34.676 -0.878  1.00 15.70 ? 29  PHE H CE2 1 
ATOM   889  C CZ  . PHE B 2 29  ? 20.759  33.981 -0.188  1.00 13.63 ? 29  PHE H CZ  1 
ATOM   890  N N   . SER B 2 30  ? 26.272  32.207 -1.787  1.00 14.09 ? 30  SER H N   1 
ATOM   891  C CA  . SER B 2 30  ? 26.308  32.097 -3.233  1.00 14.23 ? 30  SER H CA  1 
ATOM   892  C C   . SER B 2 30  ? 26.413  30.666 -3.745  1.00 13.62 ? 30  SER H C   1 
ATOM   893  O O   . SER B 2 30  ? 26.117  30.417 -4.921  1.00 14.11 ? 30  SER H O   1 
ATOM   894  C CB  . SER B 2 30  ? 27.512  32.899 -3.732  1.00 20.34 ? 30  SER H CB  1 
ATOM   895  O OG  . SER B 2 30  ? 27.263  33.380 -5.034  1.00 31.93 ? 30  SER H OG  1 
ATOM   896  N N   . LYS B 2 31  ? 26.856  29.718 -2.923  1.00 12.23 ? 31  LYS H N   1 
ATOM   897  C CA  . LYS B 2 31  ? 27.094  28.366 -3.406  1.00 13.19 ? 31  LYS H CA  1 
ATOM   898  C C   . LYS B 2 31  ? 25.925  27.412 -3.156  1.00 13.09 ? 31  LYS H C   1 
ATOM   899  O O   . LYS B 2 31  ? 26.105  26.195 -3.276  1.00 13.08 ? 31  LYS H O   1 
ATOM   900  C CB  . LYS B 2 31  ? 28.382  27.818 -2.791  1.00 15.01 ? 31  LYS H CB  1 
ATOM   901  C CG  . LYS B 2 31  ? 29.598  28.684 -3.146  1.00 18.00 ? 31  LYS H CG  1 
ATOM   902  C CD  . LYS B 2 31  ? 30.909  27.904 -3.064  1.00 26.51 ? 31  LYS H CD  1 
ATOM   903  C CE  . LYS B 2 31  ? 30.860  26.660 -3.937  1.00 27.36 ? 31  LYS H CE  1 
ATOM   904  N NZ  . LYS B 2 31  ? 30.882  26.941 -5.397  1.00 29.35 ? 31  LYS H NZ  1 
ATOM   905  N N   . TYR B 2 32  ? 24.727  27.926 -2.853  1.00 11.78 ? 32  TYR H N   1 
ATOM   906  C CA  . TYR B 2 32  ? 23.601  27.051 -2.541  1.00 11.59 ? 32  TYR H CA  1 
ATOM   907  C C   . TYR B 2 32  ? 22.322  27.536 -3.204  1.00 10.25 ? 32  TYR H C   1 
ATOM   908  O O   . TYR B 2 32  ? 22.056  28.746 -3.273  1.00 10.98 ? 32  TYR H O   1 
ATOM   909  C CB  . TYR B 2 32  ? 23.368  26.948 -1.022  1.00 10.58 ? 32  TYR H CB  1 
ATOM   910  C CG  . TYR B 2 32  ? 24.567  26.447 -0.256  1.00 12.64 ? 32  TYR H CG  1 
ATOM   911  C CD1 . TYR B 2 32  ? 25.622  27.310 0.044   1.00 11.78 ? 32  TYR H CD1 1 
ATOM   912  C CD2 . TYR B 2 32  ? 24.665  25.115 0.151   1.00 12.60 ? 32  TYR H CD2 1 
ATOM   913  C CE1 . TYR B 2 32  ? 26.738  26.875 0.739   1.00 13.90 ? 32  TYR H CE1 1 
ATOM   914  C CE2 . TYR B 2 32  ? 25.794  24.661 0.853   1.00 14.04 ? 32  TYR H CE2 1 
ATOM   915  C CZ  . TYR B 2 32  ? 26.828  25.558 1.138   1.00 14.42 ? 32  TYR H CZ  1 
ATOM   916  O OH  . TYR B 2 32  ? 27.957  25.173 1.826   1.00 16.17 ? 32  TYR H OH  1 
ATOM   917  N N   . VAL B 2 33  ? 21.525  26.578 -3.668  1.00 10.64 ? 33  VAL H N   1 
ATOM   918  C CA  . VAL B 2 33  ? 20.139  26.842 -4.042  1.00 9.29  ? 33  VAL H CA  1 
ATOM   919  C C   . VAL B 2 33  ? 19.357  27.182 -2.781  1.00 10.02 ? 33  VAL H C   1 
ATOM   920  O O   . VAL B 2 33  ? 19.486  26.498 -1.759  1.00 10.88 ? 33  VAL H O   1 
ATOM   921  C CB  . VAL B 2 33  ? 19.540  25.623 -4.761  1.00 10.45 ? 33  VAL H CB  1 
ATOM   922  C CG1 . VAL B 2 33  ? 18.061  25.858 -5.079  1.00 9.23  ? 33  VAL H CG1 1 
ATOM   923  C CG2 . VAL B 2 33  ? 20.341  25.318 -6.025  1.00 11.42 ? 33  VAL H CG2 1 
ATOM   924  N N   . MET B 2 34  ? 18.549  28.233 -2.841  1.00 9.33  ? 34  MET H N   1 
ATOM   925  C CA  . MET B 2 34  ? 17.733  28.672 -1.708  1.00 8.70  ? 34  MET H CA  1 
ATOM   926  C C   . MET B 2 34  ? 16.242  28.542 -2.019  1.00 11.09 ? 34  MET H C   1 
ATOM   927  O O   . MET B 2 34  ? 15.825  28.644 -3.173  1.00 10.65 ? 34  MET H O   1 
ATOM   928  C CB  . MET B 2 34  ? 18.064  30.124 -1.342  1.00 7.93  ? 34  MET H CB  1 
ATOM   929  C CG  . MET B 2 34  ? 19.519  30.331 -0.827  1.00 8.16  ? 34  MET H CG  1 
ATOM   930  S SD  . MET B 2 34  ? 19.881  29.437 0.700   1.00 11.77 ? 34  MET H SD  1 
ATOM   931  C CE  . MET B 2 34  ? 18.781  30.154 1.861   1.00 10.48 ? 34  MET H CE  1 
ATOM   932  N N   . HIS B 2 35  ? 15.424  28.333 -0.981  1.00 7.89  ? 35  HIS H N   1 
ATOM   933  C CA  . HIS B 2 35  ? 13.991  28.133 -1.190  1.00 9.35  ? 35  HIS H CA  1 
ATOM   934  C C   . HIS B 2 35  ? 13.150  28.872 -0.160  1.00 9.19  ? 35  HIS H C   1 
ATOM   935  O O   . HIS B 2 35  ? 13.595  29.183 0.943   1.00 10.73 ? 35  HIS H O   1 
ATOM   936  C CB  . HIS B 2 35  ? 13.575  26.654 -1.107  1.00 10.03 ? 35  HIS H CB  1 
ATOM   937  C CG  . HIS B 2 35  ? 14.285  25.759 -2.060  1.00 10.36 ? 35  HIS H CG  1 
ATOM   938  N ND1 . HIS B 2 35  ? 13.859  25.553 -3.354  1.00 12.05 ? 35  HIS H ND1 1 
ATOM   939  C CD2 . HIS B 2 35  ? 15.402  25.014 -1.906  1.00 7.51  ? 35  HIS H CD2 1 
ATOM   940  C CE1 . HIS B 2 35  ? 14.681  24.707 -3.952  1.00 11.06 ? 35  HIS H CE1 1 
ATOM   941  N NE2 . HIS B 2 35  ? 15.617  24.355 -3.091  1.00 10.25 ? 35  HIS H NE2 1 
ATOM   942  N N   . TRP B 2 36  ? 11.893  29.102 -0.533  1.00 9.24  ? 36  TRP H N   1 
ATOM   943  C CA  . TRP B 2 36  ? 10.823  29.461 0.387   1.00 10.76 ? 36  TRP H CA  1 
ATOM   944  C C   . TRP B 2 36  ? 9.847   28.301 0.447   1.00 9.95  ? 36  TRP H C   1 
ATOM   945  O O   . TRP B 2 36  ? 9.400   27.812 -0.599  1.00 9.75  ? 36  TRP H O   1 
ATOM   946  C CB  . TRP B 2 36  ? 10.082  30.718 -0.059  1.00 10.70 ? 36  TRP H CB  1 
ATOM   947  C CG  . TRP B 2 36  ? 10.880  31.964 0.057   1.00 10.99 ? 36  TRP H CG  1 
ATOM   948  C CD1 . TRP B 2 36  ? 11.538  32.609 -0.946  1.00 11.17 ? 36  TRP H CD1 1 
ATOM   949  C CD2 . TRP B 2 36  ? 11.101  32.724 1.245   1.00 11.62 ? 36  TRP H CD2 1 
ATOM   950  N NE1 . TRP B 2 36  ? 12.156  33.734 -0.453  1.00 10.70 ? 36  TRP H NE1 1 
ATOM   951  C CE2 . TRP B 2 36  ? 11.915  33.818 0.894   1.00 10.98 ? 36  TRP H CE2 1 
ATOM   952  C CE3 . TRP B 2 36  ? 10.710  32.570 2.582   1.00 10.57 ? 36  TRP H CE3 1 
ATOM   953  C CZ2 . TRP B 2 36  ? 12.325  34.775 1.823   1.00 12.78 ? 36  TRP H CZ2 1 
ATOM   954  C CZ3 . TRP B 2 36  ? 11.125  33.526 3.508   1.00 12.28 ? 36  TRP H CZ3 1 
ATOM   955  C CH2 . TRP B 2 36  ? 11.928  34.607 3.126   1.00 12.82 ? 36  TRP H CH2 1 
ATOM   956  N N   . VAL B 2 37  ? 9.530   27.862 1.663   1.00 7.19  ? 37  VAL H N   1 
ATOM   957  C CA  . VAL B 2 37  ? 8.578   26.787 1.922   1.00 9.41  ? 37  VAL H CA  1 
ATOM   958  C C   . VAL B 2 37  ? 7.559   27.337 2.913   1.00 10.19 ? 37  VAL H C   1 
ATOM   959  O O   . VAL B 2 37  ? 7.934   28.039 3.856   1.00 10.93 ? 37  VAL H O   1 
ATOM   960  C CB  . VAL B 2 37  ? 9.294   25.534 2.496   1.00 7.48  ? 37  VAL H CB  1 
ATOM   961  C CG1 . VAL B 2 37  ? 8.307   24.438 2.835   1.00 9.87  ? 37  VAL H CG1 1 
ATOM   962  C CG2 . VAL B 2 37  ? 10.357  25.000 1.530   1.00 11.20 ? 37  VAL H CG2 1 
ATOM   963  N N   . ARG B 2 38  ? 6.274   27.029 2.721   1.00 7.78  ? 38  ARG H N   1 
ATOM   964  C CA  . ARG B 2 38  ? 5.268   27.587 3.617   1.00 10.14 ? 38  ARG H CA  1 
ATOM   965  C C   . ARG B 2 38  ? 4.417   26.490 4.250   1.00 10.23 ? 38  ARG H C   1 
ATOM   966  O O   . ARG B 2 38  ? 4.324   25.361 3.766   1.00 10.05 ? 38  ARG H O   1 
ATOM   967  C CB  . ARG B 2 38  ? 4.384   28.611 2.904   1.00 9.26  ? 38  ARG H CB  1 
ATOM   968  C CG  . ARG B 2 38  ? 3.446   28.007 1.899   1.00 11.35 ? 38  ARG H CG  1 
ATOM   969  C CD  . ARG B 2 38  ? 2.697   29.106 1.150   1.00 12.08 ? 38  ARG H CD  1 
ATOM   970  N NE  . ARG B 2 38  ? 1.744   28.534 0.209   1.00 11.77 ? 38  ARG H NE  1 
ATOM   971  C CZ  . ARG B 2 38  ? 0.938   29.252 -0.563  1.00 11.45 ? 38  ARG H CZ  1 
ATOM   972  N NH1 . ARG B 2 38  ? 0.991   30.569 -0.568  1.00 12.18 ? 38  ARG H NH1 1 
ATOM   973  N NH2 . ARG B 2 38  ? 0.060   28.626 -1.347  1.00 15.54 ? 38  ARG H NH2 1 
ATOM   974  N N   . GLN B 2 39  ? 3.772   26.853 5.350   1.00 10.86 ? 39  GLN H N   1 
ATOM   975  C CA  . GLN B 2 39  ? 2.930   25.932 6.110   1.00 12.60 ? 39  GLN H CA  1 
ATOM   976  C C   . GLN B 2 39  ? 1.721   26.722 6.596   1.00 11.11 ? 39  GLN H C   1 
ATOM   977  O O   . GLN B 2 39  ? 1.842   27.589 7.476   1.00 10.84 ? 39  GLN H O   1 
ATOM   978  C CB  . GLN B 2 39  ? 3.704   25.310 7.272   1.00 12.45 ? 39  GLN H CB  1 
ATOM   979  C CG  . GLN B 2 39  ? 2.949   24.237 8.043   1.00 12.76 ? 39  GLN H CG  1 
ATOM   980  C CD  . GLN B 2 39  ? 3.891   23.478 8.955   1.00 14.34 ? 39  GLN H CD  1 
ATOM   981  O OE1 . GLN B 2 39  ? 4.783   24.075 9.579   1.00 16.10 ? 39  GLN H OE1 1 
ATOM   982  N NE2 . GLN B 2 39  ? 3.755   22.164 8.986   1.00 12.25 ? 39  GLN H NE2 1 
ATOM   983  N N   . ALA B 2 40  ? 0.564   26.451 5.998   1.00 12.36 ? 40  ALA H N   1 
ATOM   984  C CA  . ALA B 2 40  ? -0.673  27.058 6.454   1.00 14.27 ? 40  ALA H CA  1 
ATOM   985  C C   . ALA B 2 40  ? -1.069  26.449 7.801   1.00 14.68 ? 40  ALA H C   1 
ATOM   986  O O   . ALA B 2 40  ? -0.652  25.337 8.130   1.00 13.91 ? 40  ALA H O   1 
ATOM   987  C CB  . ALA B 2 40  ? -1.778  26.859 5.415   1.00 13.66 ? 40  ALA H CB  1 
ATOM   988  N N   . PRO B 2 41  ? -1.863  27.166 8.600   1.00 18.48 ? 41  PRO H N   1 
ATOM   989  C CA  . PRO B 2 41  ? -2.177  26.682 9.954   1.00 17.51 ? 41  PRO H CA  1 
ATOM   990  C C   . PRO B 2 41  ? -2.856  25.321 9.915   1.00 18.13 ? 41  PRO H C   1 
ATOM   991  O O   . PRO B 2 41  ? -3.838  25.112 9.196   1.00 20.89 ? 41  PRO H O   1 
ATOM   992  C CB  . PRO B 2 41  ? -3.109  27.767 10.510  1.00 19.47 ? 41  PRO H CB  1 
ATOM   993  C CG  . PRO B 2 41  ? -2.803  28.976 9.718   1.00 20.29 ? 41  PRO H CG  1 
ATOM   994  C CD  . PRO B 2 41  ? -2.497  28.468 8.335   1.00 18.59 ? 41  PRO H CD  1 
ATOM   995  N N   . GLY B 2 42  ? -2.295  24.381 10.666  1.00 20.61 ? 42  GLY H N   1 
ATOM   996  C CA  . GLY B 2 42  ? -2.835  23.037 10.706  1.00 19.38 ? 42  GLY H CA  1 
ATOM   997  C C   . GLY B 2 42  ? -2.549  22.176 9.502   1.00 21.72 ? 42  GLY H C   1 
ATOM   998  O O   . GLY B 2 42  ? -3.078  21.070 9.421   1.00 22.95 ? 42  GLY H O   1 
ATOM   999  N N   . LYS B 2 43  ? -1.733  22.636 8.563   1.00 17.94 ? 43  LYS H N   1 
ATOM   1000 C CA  . LYS B 2 43  ? -1.483  21.926 7.318   1.00 16.03 ? 43  LYS H CA  1 
ATOM   1001 C C   . LYS B 2 43  ? -0.008  21.531 7.234   1.00 14.64 ? 43  LYS H C   1 
ATOM   1002 O O   . LYS B 2 43  ? 0.782   21.763 8.150   1.00 12.29 ? 43  LYS H O   1 
ATOM   1003 C CB  . LYS B 2 43  ? -1.894  22.775 6.109   1.00 14.73 ? 43  LYS H CB  1 
ATOM   1004 C CG  . LYS B 2 43  ? -3.411  22.970 5.983   1.00 18.77 ? 43  LYS H CG  1 
ATOM   1005 N N   . GLY B 2 44  ? 0.369   20.930 6.104   1.00 12.83 ? 44  GLY H N   1 
ATOM   1006 C CA  . GLY B 2 44  ? 1.710   20.424 5.911   1.00 12.98 ? 44  GLY H CA  1 
ATOM   1007 C C   . GLY B 2 44  ? 2.615   21.423 5.210   1.00 13.13 ? 44  GLY H C   1 
ATOM   1008 O O   . GLY B 2 44  ? 2.318   22.614 5.089   1.00 16.30 ? 44  GLY H O   1 
ATOM   1009 N N   . LEU B 2 45  ? 3.760   20.916 4.771   1.00 11.11 ? 45  LEU H N   1 
ATOM   1010 C CA  . LEU B 2 45  ? 4.786   21.729 4.123   1.00 10.68 ? 45  LEU H CA  1 
ATOM   1011 C C   . LEU B 2 45  ? 4.496   21.816 2.633   1.00 11.23 ? 45  LEU H C   1 
ATOM   1012 O O   . LEU B 2 45  ? 4.224   20.796 1.994   1.00 14.84 ? 45  LEU H O   1 
ATOM   1013 C CB  . LEU B 2 45  ? 6.166   21.112 4.353   1.00 9.70  ? 45  LEU H CB  1 
ATOM   1014 C CG  . LEU B 2 45  ? 6.502   20.907 5.832   1.00 10.40 ? 45  LEU H CG  1 
ATOM   1015 C CD1 . LEU B 2 45  ? 7.841   20.202 5.986   1.00 12.29 ? 45  LEU H CD1 1 
ATOM   1016 C CD2 . LEU B 2 45  ? 6.554   22.234 6.520   1.00 11.30 ? 45  LEU H CD2 1 
ATOM   1017 N N   . GLU B 2 46  ? 4.550   23.032 2.088   1.00 10.40 ? 46  GLU H N   1 
ATOM   1018 C CA  . GLU B 2 46  ? 4.352   23.273 0.662   1.00 10.44 ? 46  GLU H CA  1 
ATOM   1019 C C   . GLU B 2 46  ? 5.511   24.119 0.163   1.00 9.54  ? 46  GLU H C   1 
ATOM   1020 O O   . GLU B 2 46  ? 5.679   25.262 0.600   1.00 9.48  ? 46  GLU H O   1 
ATOM   1021 C CB  . GLU B 2 46  ? 3.026   23.996 0.384   1.00 10.09 ? 46  GLU H CB  1 
ATOM   1022 C CG  . GLU B 2 46  ? 2.857   24.353 -1.094  1.00 13.43 ? 46  GLU H CG  1 
ATOM   1023 C CD  . GLU B 2 46  ? 1.631   25.218 -1.384  1.00 16.02 ? 46  GLU H CD  1 
ATOM   1024 O OE1 . GLU B 2 46  ? 1.130   25.916 -0.467  1.00 13.78 ? 46  GLU H OE1 1 
ATOM   1025 O OE2 . GLU B 2 46  ? 1.174   25.221 -2.555  1.00 18.77 ? 46  GLU H OE2 1 
ATOM   1026 N N   . TRP B 2 47  ? 6.313   23.558 -0.732  1.00 9.44  ? 47  TRP H N   1 
ATOM   1027 C CA  . TRP B 2 47  ? 7.348   24.341 -1.404  1.00 10.01 ? 47  TRP H CA  1 
ATOM   1028 C C   . TRP B 2 47  ? 6.706   25.424 -2.271  1.00 10.96 ? 47  TRP H C   1 
ATOM   1029 O O   . TRP B 2 47  ? 5.753   25.160 -3.009  1.00 12.34 ? 47  TRP H O   1 
ATOM   1030 C CB  . TRP B 2 47  ? 8.227   23.421 -2.254  1.00 10.70 ? 47  TRP H CB  1 
ATOM   1031 C CG  . TRP B 2 47  ? 9.204   24.136 -3.141  1.00 10.04 ? 47  TRP H CG  1 
ATOM   1032 C CD1 . TRP B 2 47  ? 10.430  24.634 -2.788  1.00 11.38 ? 47  TRP H CD1 1 
ATOM   1033 C CD2 . TRP B 2 47  ? 9.040   24.423 -4.540  1.00 11.65 ? 47  TRP H CD2 1 
ATOM   1034 N NE1 . TRP B 2 47  ? 11.044  25.206 -3.889  1.00 11.95 ? 47  TRP H NE1 1 
ATOM   1035 C CE2 . TRP B 2 47  ? 10.207  25.097 -4.969  1.00 10.78 ? 47  TRP H CE2 1 
ATOM   1036 C CE3 . TRP B 2 47  ? 8.018   24.180 -5.466  1.00 11.91 ? 47  TRP H CE3 1 
ATOM   1037 C CZ2 . TRP B 2 47  ? 10.385  25.526 -6.286  1.00 12.40 ? 47  TRP H CZ2 1 
ATOM   1038 C CZ3 . TRP B 2 47  ? 8.194   24.605 -6.782  1.00 11.97 ? 47  TRP H CZ3 1 
ATOM   1039 C CH2 . TRP B 2 47  ? 9.374   25.271 -7.178  1.00 11.36 ? 47  TRP H CH2 1 
ATOM   1040 N N   . VAL B 2 48  ? 7.241   26.636 -2.176  1.00 10.88 ? 48  VAL H N   1 
ATOM   1041 C CA  . VAL B 2 48  ? 6.704   27.810 -2.854  1.00 12.01 ? 48  VAL H CA  1 
ATOM   1042 C C   . VAL B 2 48  ? 7.560   28.193 -4.050  1.00 12.35 ? 48  VAL H C   1 
ATOM   1043 O O   . VAL B 2 48  ? 7.055   28.390 -5.160  1.00 13.51 ? 48  VAL H O   1 
ATOM   1044 C CB  . VAL B 2 48  ? 6.586   28.997 -1.872  1.00 13.20 ? 48  VAL H CB  1 
ATOM   1045 C CG1 . VAL B 2 48  ? 5.964   30.170 -2.558  1.00 19.06 ? 48  VAL H CG1 1 
ATOM   1046 C CG2 . VAL B 2 48  ? 5.782   28.592 -0.666  1.00 18.35 ? 48  VAL H CG2 1 
ATOM   1047 N N   . THR B 2 49  ? 8.866   28.325 -3.836  1.00 12.08 ? 49  THR H N   1 
ATOM   1048 C CA  . THR B 2 49  ? 9.719   28.841 -4.891  1.00 10.45 ? 49  THR H CA  1 
ATOM   1049 C C   . THR B 2 49  ? 11.159  28.595 -4.487  1.00 11.44 ? 49  THR H C   1 
ATOM   1050 O O   . THR B 2 49  ? 11.472  28.531 -3.290  1.00 10.50 ? 49  THR H O   1 
ATOM   1051 C CB  . THR B 2 49  ? 9.463   30.337 -5.131  1.00 12.17 ? 49  THR H CB  1 
ATOM   1052 O OG1 . THR B 2 49  ? 10.404  30.837 -6.087  1.00 13.54 ? 49  THR H OG1 1 
ATOM   1053 C CG2 . THR B 2 49  ? 9.589   31.152 -3.819  1.00 10.90 ? 49  THR H CG2 1 
ATOM   1054 N N   . GLY B 2 50  ? 12.019  28.440 -5.493  1.00 10.57 ? 50  GLY H N   1 
ATOM   1055 C CA  . GLY B 2 50  ? 13.448  28.320 -5.265  1.00 12.69 ? 50  GLY H CA  1 
ATOM   1056 C C   . GLY B 2 50  ? 14.227  29.065 -6.333  1.00 12.57 ? 50  GLY H C   1 
ATOM   1057 O O   . GLY B 2 50  ? 13.700  29.404 -7.398  1.00 11.76 ? 50  GLY H O   1 
ATOM   1058 N N   . ILE B 2 51  ? 15.502  29.304 -6.043  1.00 10.96 ? 51  ILE H N   1 
ATOM   1059 C CA  . ILE B 2 51  ? 16.330  30.154 -6.897  1.00 11.29 ? 51  ILE H CA  1 
ATOM   1060 C C   . ILE B 2 51  ? 17.739  29.585 -6.936  1.00 13.55 ? 51  ILE H C   1 
ATOM   1061 O O   . ILE B 2 51  ? 18.270  29.153 -5.911  1.00 13.23 ? 51  ILE H O   1 
ATOM   1062 C CB  . ILE B 2 51  ? 16.288  31.622 -6.410  1.00 13.44 ? 51  ILE H CB  1 
ATOM   1063 C CG1 . ILE B 2 51  ? 17.031  32.548 -7.370  1.00 12.45 ? 51  ILE H CG1 1 
ATOM   1064 C CG2 . ILE B 2 51  ? 16.816  31.759 -4.968  1.00 11.36 ? 51  ILE H CG2 1 
ATOM   1065 C CD1 . ILE B 2 51  ? 16.829  34.011 -7.026  1.00 12.13 ? 51  ILE H CD1 1 
ATOM   1066 N N   . SER B 2 52  ? 18.326  29.549 -8.131  1.00 12.29 ? 52  SER H N   1 
ATOM   1067 C CA  . SER B 2 52  ? 19.624  28.928 -8.338  1.00 13.08 ? 52  SER H CA  1 
ATOM   1068 C C   . SER B 2 52  ? 20.734  29.780 -7.716  1.00 13.17 ? 52  SER H C   1 
ATOM   1069 O O   . SER B 2 52  ? 20.528  30.920 -7.284  1.00 14.09 ? 52  SER H O   1 
ATOM   1070 C CB  . SER B 2 52  ? 19.887  28.712 -9.834  1.00 15.14 ? 52  SER H CB  1 
ATOM   1071 O OG  . SER B 2 52  ? 20.089  29.956 -10.510 1.00 17.26 ? 52  SER H OG  1 
ATOM   1072 N N   . TYR B 2 53  ? 21.933  29.184 -7.697  1.00 11.13 ? 53  TYR H N   1 
ATOM   1073 C CA  . TYR B 2 53  ? 23.109  29.716 -7.007  1.00 13.96 ? 53  TYR H CA  1 
ATOM   1074 C C   . TYR B 2 53  ? 23.308  31.211 -7.250  1.00 13.28 ? 53  TYR H C   1 
ATOM   1075 O O   . TYR B 2 53  ? 23.461  31.999 -6.312  1.00 14.65 ? 53  TYR H O   1 
ATOM   1076 C CB  . TYR B 2 53  ? 24.341  28.919 -7.468  1.00 15.39 ? 53  TYR H CB  1 
ATOM   1077 C CG  . TYR B 2 53  ? 24.142  27.425 -7.305  1.00 15.02 ? 53  TYR H CG  1 
ATOM   1078 C CD1 . TYR B 2 53  ? 23.625  26.642 -8.340  1.00 13.97 ? 53  TYR H CD1 1 
ATOM   1079 C CD2 . TYR B 2 53  ? 24.425  26.805 -6.098  1.00 14.30 ? 53  TYR H CD2 1 
ATOM   1080 C CE1 . TYR B 2 53  ? 23.411  25.275 -8.174  1.00 15.24 ? 53  TYR H CE1 1 
ATOM   1081 C CE2 . TYR B 2 53  ? 24.219  25.444 -5.922  1.00 12.86 ? 53  TYR H CE2 1 
ATOM   1082 C CZ  . TYR B 2 53  ? 23.709  24.682 -6.965  1.00 13.00 ? 53  TYR H CZ  1 
ATOM   1083 O OH  . TYR B 2 53  ? 23.489  23.332 -6.804  1.00 12.69 ? 53  TYR H OH  1 
ATOM   1084 N N   . ASP B 2 54  ? 23.287  31.602 -8.517  1.00 14.03 ? 54  ASP H N   1 
ATOM   1085 C CA  . ASP B 2 54  ? 23.629  32.920 -9.031  1.00 19.44 ? 54  ASP H CA  1 
ATOM   1086 C C   . ASP B 2 54  ? 22.427  33.843 -9.145  1.00 19.65 ? 54  ASP H C   1 
ATOM   1087 O O   . ASP B 2 54  ? 22.578  34.993 -9.573  1.00 18.52 ? 54  ASP H O   1 
ATOM   1088 C CB  . ASP B 2 54  ? 24.217  32.723 -10.416 1.00 22.03 ? 54  ASP H CB  1 
ATOM   1089 C CG  . ASP B 2 54  ? 23.404  31.718 -11.206 1.00 27.18 ? 54  ASP H CG  1 
ATOM   1090 O OD1 . ASP B 2 54  ? 23.116  30.589 -10.691 1.00 27.81 ? 54  ASP H OD1 1 
ATOM   1091 O OD2 . ASP B 2 54  ? 23.008  32.043 -12.331 1.00 33.46 ? 54  ASP H OD2 1 
ATOM   1092 N N   . GLY B 2 55  ? 21.237  33.347 -8.851  1.00 16.36 ? 55  GLY H N   1 
ATOM   1093 C CA  . GLY B 2 55  ? 20.029  34.127 -8.988  1.00 17.02 ? 55  GLY H CA  1 
ATOM   1094 C C   . GLY B 2 55  ? 19.419  34.110 -10.371 1.00 20.42 ? 55  GLY H C   1 
ATOM   1095 O O   . GLY B 2 55  ? 18.327  34.660 -10.551 1.00 21.07 ? 55  GLY H O   1 
ATOM   1096 N N   . ARG B 2 56  ? 20.074  33.490 -11.353 1.00 18.20 ? 56  ARG H N   1 
ATOM   1097 C CA  . ARG B 2 56  ? 19.572  33.580 -12.718 1.00 18.75 ? 56  ARG H CA  1 
ATOM   1098 C C   . ARG B 2 56  ? 18.368  32.683 -12.979 1.00 22.06 ? 56  ARG H C   1 
ATOM   1099 O O   . ARG B 2 56  ? 17.577  33.002 -13.874 1.00 18.97 ? 56  ARG H O   1 
ATOM   1100 C CB  . ARG B 2 56  ? 20.681  33.269 -13.732 1.00 22.74 ? 56  ARG H CB  1 
ATOM   1101 C CG  . ARG B 2 56  ? 21.726  34.382 -13.844 1.00 21.75 ? 56  ARG H CG  1 
ATOM   1102 C CD  . ARG B 2 56  ? 22.808  34.048 -14.882 1.00 22.04 ? 56  ARG H CD  1 
ATOM   1103 N NE  . ARG B 2 56  ? 23.496  32.800 -14.574 1.00 19.65 ? 56  ARG H NE  1 
ATOM   1104 C CZ  . ARG B 2 56  ? 23.320  31.664 -15.238 1.00 23.38 ? 56  ARG H CZ  1 
ATOM   1105 N NH1 . ARG B 2 56  ? 22.513  31.592 -16.281 1.00 23.91 ? 56  ARG H NH1 1 
ATOM   1106 N NH2 . ARG B 2 56  ? 23.968  30.572 -14.841 1.00 26.54 ? 56  ARG H NH2 1 
ATOM   1107 N N   . HIS B 2 57  ? 18.187  31.597 -12.224 1.00 16.35 ? 57  HIS H N   1 
ATOM   1108 C CA  . HIS B 2 57  ? 17.108  30.653 -12.488 1.00 18.55 ? 57  HIS H CA  1 
ATOM   1109 C C   . HIS B 2 57  ? 16.141  30.617 -11.314 1.00 18.04 ? 57  HIS H C   1 
ATOM   1110 O O   . HIS B 2 57  ? 16.555  30.422 -10.168 1.00 13.27 ? 57  HIS H O   1 
ATOM   1111 C CB  . HIS B 2 57  ? 17.660  29.267 -12.779 1.00 22.23 ? 57  HIS H CB  1 
ATOM   1112 C CG  . HIS B 2 57  ? 18.634  29.250 -13.913 1.00 24.42 ? 57  HIS H CG  1 
ATOM   1113 N ND1 . HIS B 2 57  ? 18.261  29.515 -15.213 1.00 26.25 ? 57  HIS H ND1 1 
ATOM   1114 C CD2 . HIS B 2 57  ? 19.968  29.024 -13.941 1.00 22.45 ? 57  HIS H CD2 1 
ATOM   1115 C CE1 . HIS B 2 57  ? 19.322  29.442 -15.996 1.00 27.28 ? 57  HIS H CE1 1 
ATOM   1116 N NE2 . HIS B 2 57  ? 20.373  29.151 -15.249 1.00 26.50 ? 57  HIS H NE2 1 
ATOM   1117 N N   . LYS B 2 58  ? 14.861  30.821 -11.603 1.00 16.42 ? 58  LYS H N   1 
ATOM   1118 C CA  . LYS B 2 58  ? 13.824  30.897 -10.585 1.00 15.89 ? 58  LYS H CA  1 
ATOM   1119 C C   . LYS B 2 58  ? 12.776  29.838 -10.887 1.00 16.56 ? 58  LYS H C   1 
ATOM   1120 O O   . LYS B 2 58  ? 12.394  29.639 -12.047 1.00 15.26 ? 58  LYS H O   1 
ATOM   1121 C CB  . LYS B 2 58  ? 13.214  32.306 -10.533 1.00 15.33 ? 58  LYS H CB  1 
ATOM   1122 C CG  . LYS B 2 58  ? 14.246  33.379 -10.173 1.00 16.59 ? 58  LYS H CG  1 
ATOM   1123 C CD  . LYS B 2 58  ? 14.175  34.567 -11.110 1.00 22.19 ? 58  LYS H CD  1 
ATOM   1124 C CE  . LYS B 2 58  ? 15.305  35.561 -10.844 1.00 22.27 ? 58  LYS H CE  1 
ATOM   1125 N NZ  . LYS B 2 58  ? 16.145  35.754 -12.068 1.00 24.46 ? 58  LYS H NZ  1 
ATOM   1126 N N   . TYR B 2 59  ? 12.349  29.120 -9.849  1.00 12.74 ? 59  TYR H N   1 
ATOM   1127 C CA  . TYR B 2 59  ? 11.404  28.023 -10.016 1.00 12.85 ? 59  TYR H CA  1 
ATOM   1128 C C   . TYR B 2 59  ? 10.246  28.267 -9.071  1.00 13.74 ? 59  TYR H C   1 
ATOM   1129 O O   . TYR B 2 59  ? 10.460  28.702 -7.939  1.00 11.75 ? 59  TYR H O   1 
ATOM   1130 C CB  . TYR B 2 59  ? 12.044  26.659 -9.725  1.00 14.77 ? 59  TYR H CB  1 
ATOM   1131 C CG  . TYR B 2 59  ? 13.410  26.489 -10.355 1.00 14.05 ? 59  TYR H CG  1 
ATOM   1132 C CD1 . TYR B 2 59  ? 13.537  26.115 -11.694 1.00 15.71 ? 59  TYR H CD1 1 
ATOM   1133 C CD2 . TYR B 2 59  ? 14.569  26.709 -9.618  1.00 14.63 ? 59  TYR H CD2 1 
ATOM   1134 C CE1 . TYR B 2 59  ? 14.794  25.977 -12.276 1.00 17.10 ? 59  TYR H CE1 1 
ATOM   1135 C CE2 . TYR B 2 59  ? 15.825  26.575 -10.199 1.00 17.74 ? 59  TYR H CE2 1 
ATOM   1136 C CZ  . TYR B 2 59  ? 15.925  26.215 -11.522 1.00 17.35 ? 59  TYR H CZ  1 
ATOM   1137 O OH  . TYR B 2 59  ? 17.172  26.071 -12.084 1.00 18.86 ? 59  TYR H OH  1 
ATOM   1138 N N   . TYR B 2 60  ? 9.021   28.002 -9.534  1.00 12.15 ? 60  TYR H N   1 
ATOM   1139 C CA  . TYR B 2 60  ? 7.832   28.377 -8.779  1.00 13.02 ? 60  TYR H CA  1 
ATOM   1140 C C   . TYR B 2 60  ? 6.817   27.249 -8.748  1.00 13.76 ? 60  TYR H C   1 
ATOM   1141 O O   . TYR B 2 60  ? 6.608   26.558 -9.748  1.00 15.62 ? 60  TYR H O   1 
ATOM   1142 C CB  . TYR B 2 60  ? 7.144   29.621 -9.367  1.00 13.36 ? 60  TYR H CB  1 
ATOM   1143 C CG  . TYR B 2 60  ? 7.984   30.874 -9.346  1.00 14.46 ? 60  TYR H CG  1 
ATOM   1144 C CD1 . TYR B 2 60  ? 8.025   31.683 -8.220  1.00 12.73 ? 60  TYR H CD1 1 
ATOM   1145 C CD2 . TYR B 2 60  ? 8.727   31.254 -10.455 1.00 13.23 ? 60  TYR H CD2 1 
ATOM   1146 C CE1 . TYR B 2 60  ? 8.791   32.835 -8.184  1.00 15.08 ? 60  TYR H CE1 1 
ATOM   1147 C CE2 . TYR B 2 60  ? 9.488   32.416 -10.442 1.00 16.55 ? 60  TYR H CE2 1 
ATOM   1148 C CZ  . TYR B 2 60  ? 9.520   33.197 -9.295  1.00 13.67 ? 60  TYR H CZ  1 
ATOM   1149 O OH  . TYR B 2 60  ? 10.271  34.343 -9.242  1.00 12.65 ? 60  TYR H OH  1 
ATOM   1150 N N   . ALA B 2 61  ? 6.141   27.111 -7.608  1.00 11.93 ? 61  ALA H N   1 
ATOM   1151 C CA  . ALA B 2 61  ? 4.957   26.272 -7.551  1.00 14.13 ? 61  ALA H CA  1 
ATOM   1152 C C   . ALA B 2 61  ? 3.845   26.923 -8.363  1.00 13.24 ? 61  ALA H C   1 
ATOM   1153 O O   . ALA B 2 61  ? 3.716   28.147 -8.379  1.00 14.05 ? 61  ALA H O   1 
ATOM   1154 C CB  . ALA B 2 61  ? 4.505   26.076 -6.108  1.00 12.16 ? 61  ALA H CB  1 
ATOM   1155 N N   . ASP B 2 62  ? 3.041   26.098 -9.039  1.00 15.71 ? 62  ASP H N   1 
ATOM   1156 C CA  . ASP B 2 62  ? 1.859   26.614 -9.734  1.00 15.74 ? 62  ASP H CA  1 
ATOM   1157 C C   . ASP B 2 62  ? 0.986   27.477 -8.830  1.00 15.89 ? 62  ASP H C   1 
ATOM   1158 O O   . ASP B 2 62  ? 0.414   28.475 -9.279  1.00 16.98 ? 62  ASP H O   1 
ATOM   1159 C CB  . ASP B 2 62  ? 1.033   25.458 -10.278 1.00 19.26 ? 62  ASP H CB  1 
ATOM   1160 C CG  . ASP B 2 62  ? 1.656   24.814 -11.482 1.00 19.62 ? 62  ASP H CG  1 
ATOM   1161 O OD1 . ASP B 2 62  ? 2.459   25.477 -12.181 1.00 23.15 ? 62  ASP H OD1 1 
ATOM   1162 O OD2 . ASP B 2 62  ? 1.317   23.638 -11.736 1.00 22.21 ? 62  ASP H OD2 1 
ATOM   1163 N N   . SER B 2 63  ? 0.894   27.130 -7.540  1.00 17.24 ? 63  SER H N   1 
ATOM   1164 C CA  . SER B 2 63  ? 0.016   27.864 -6.634  1.00 19.83 ? 63  SER H CA  1 
ATOM   1165 C C   . SER B 2 63  ? 0.387   29.339 -6.502  1.00 18.91 ? 63  SER H C   1 
ATOM   1166 O O   . SER B 2 63  ? -0.459  30.123 -6.069  1.00 18.32 ? 63  SER H O   1 
ATOM   1167 C CB  . SER B 2 63  ? -0.005  27.207 -5.243  1.00 18.24 ? 63  SER H CB  1 
ATOM   1168 O OG  . SER B 2 63  ? 1.304   26.985 -4.723  1.00 17.92 ? 63  SER H OG  1 
ATOM   1169 N N   . VAL B 2 64  ? 1.609   29.741 -6.873  1.00 16.04 ? 64  VAL H N   1 
ATOM   1170 C CA  . VAL B 2 64  ? 2.064   31.117 -6.661  1.00 15.23 ? 64  VAL H CA  1 
ATOM   1171 C C   . VAL B 2 64  ? 2.660   31.726 -7.921  1.00 13.64 ? 64  VAL H C   1 
ATOM   1172 O O   . VAL B 2 64  ? 2.986   32.918 -7.936  1.00 13.65 ? 64  VAL H O   1 
ATOM   1173 C CB  . VAL B 2 64  ? 3.095   31.205 -5.517  1.00 16.52 ? 64  VAL H CB  1 
ATOM   1174 C CG1 . VAL B 2 64  ? 2.555   30.567 -4.235  1.00 16.24 ? 64  VAL H CG1 1 
ATOM   1175 C CG2 . VAL B 2 64  ? 4.412   30.554 -5.961  1.00 14.55 ? 64  VAL H CG2 1 
ATOM   1176 N N   . LYS B 2 65  ? 2.833   30.924 -8.965  1.00 15.48 ? 65  LYS H N   1 
ATOM   1177 C CA  . LYS B 2 65  ? 3.406   31.431 -10.203 1.00 18.58 ? 65  LYS H CA  1 
ATOM   1178 C C   . LYS B 2 65  ? 2.599   32.616 -10.722 1.00 19.11 ? 65  LYS H C   1 
ATOM   1179 O O   . LYS B 2 65  ? 1.367   32.575 -10.746 1.00 18.80 ? 65  LYS H O   1 
ATOM   1180 C CB  . LYS B 2 65  ? 3.454   30.317 -11.250 1.00 20.42 ? 65  LYS H CB  1 
ATOM   1181 C CG  . LYS B 2 65  ? 4.248   30.680 -12.496 1.00 24.16 ? 65  LYS H CG  1 
ATOM   1182 C CD  . LYS B 2 65  ? 5.529   31.427 -12.122 1.00 24.34 ? 65  LYS H CD  1 
ATOM   1183 C CE  . LYS B 2 65  ? 6.243   32.004 -13.347 1.00 29.87 ? 65  LYS H CE  1 
ATOM   1184 N N   . GLY B 2 66  ? 3.297   33.688 -11.102 1.00 16.85 ? 66  GLY H N   1 
ATOM   1185 C CA  . GLY B 2 66  ? 2.651   34.889 -11.584 1.00 18.14 ? 66  GLY H CA  1 
ATOM   1186 C C   . GLY B 2 66  ? 2.187   35.834 -10.504 1.00 20.15 ? 66  GLY H C   1 
ATOM   1187 O O   . GLY B 2 66  ? 1.808   36.970 -10.814 1.00 20.00 ? 66  GLY H O   1 
ATOM   1188 N N   . ARG B 2 67  ? 2.204   35.410 -9.246  1.00 14.55 ? 67  ARG H N   1 
ATOM   1189 C CA  . ARG B 2 67  ? 1.862   36.274 -8.130  1.00 15.42 ? 67  ARG H CA  1 
ATOM   1190 C C   . ARG B 2 67  ? 3.047   36.548 -7.225  1.00 17.63 ? 67  ARG H C   1 
ATOM   1191 O O   . ARG B 2 67  ? 3.185   37.662 -6.717  1.00 18.51 ? 67  ARG H O   1 
ATOM   1192 C CB  . ARG B 2 67  ? 0.722   35.653 -7.311  1.00 14.14 ? 67  ARG H CB  1 
ATOM   1193 C CG  . ARG B 2 67  ? -0.517  35.270 -8.127  1.00 18.07 ? 67  ARG H CG  1 
ATOM   1194 C CD  . ARG B 2 67  ? -1.684  34.800 -7.246  1.00 16.96 ? 67  ARG H CD  1 
ATOM   1195 N NE  . ARG B 2 67  ? -1.382  33.609 -6.457  1.00 17.81 ? 67  ARG H NE  1 
ATOM   1196 C CZ  . ARG B 2 67  ? -1.341  33.561 -5.130  1.00 17.49 ? 67  ARG H CZ  1 
ATOM   1197 N NH1 . ARG B 2 67  ? -1.566  34.633 -4.390  1.00 15.26 ? 67  ARG H NH1 1 
ATOM   1198 N NH2 . ARG B 2 67  ? -1.051  32.407 -4.531  1.00 17.25 ? 67  ARG H NH2 1 
ATOM   1199 N N   . PHE B 2 68  ? 3.901   35.558 -6.995  1.00 15.83 ? 68  PHE H N   1 
ATOM   1200 C CA  . PHE B 2 68  ? 5.067   35.714 -6.135  1.00 13.84 ? 68  PHE H CA  1 
ATOM   1201 C C   . PHE B 2 68  ? 6.321   35.725 -6.996  1.00 13.39 ? 68  PHE H C   1 
ATOM   1202 O O   . PHE B 2 68  ? 6.374   35.061 -8.037  1.00 15.80 ? 68  PHE H O   1 
ATOM   1203 C CB  . PHE B 2 68  ? 5.196   34.571 -5.121  1.00 13.07 ? 68  PHE H CB  1 
ATOM   1204 C CG  . PHE B 2 68  ? 4.105   34.527 -4.061  1.00 15.85 ? 68  PHE H CG  1 
ATOM   1205 C CD1 . PHE B 2 68  ? 3.010   35.370 -4.113  1.00 15.90 ? 68  PHE H CD1 1 
ATOM   1206 C CD2 . PHE B 2 68  ? 4.207   33.619 -3.012  1.00 14.84 ? 68  PHE H CD2 1 
ATOM   1207 C CE1 . PHE B 2 68  ? 2.008   35.320 -3.124  1.00 18.11 ? 68  PHE H CE1 1 
ATOM   1208 C CE2 . PHE B 2 68  ? 3.218   33.552 -2.018  1.00 16.40 ? 68  PHE H CE2 1 
ATOM   1209 C CZ  . PHE B 2 68  ? 2.122   34.411 -2.077  1.00 16.42 ? 68  PHE H CZ  1 
ATOM   1210 N N   . THR B 2 69  ? 7.340   36.454 -6.532  1.00 13.96 ? 69  THR H N   1 
ATOM   1211 C CA  . THR B 2 69  ? 8.640   36.517 -7.201  1.00 13.30 ? 69  THR H CA  1 
ATOM   1212 C C   . THR B 2 69  ? 9.750   36.307 -6.184  1.00 12.83 ? 69  THR H C   1 
ATOM   1213 O O   . THR B 2 69  ? 9.746   36.937 -5.123  1.00 17.16 ? 69  THR H O   1 
ATOM   1214 C CB  . THR B 2 69  ? 8.858   37.855 -7.907  1.00 15.41 ? 69  THR H CB  1 
ATOM   1215 O OG1 . THR B 2 69  ? 7.801   38.078 -8.849  1.00 23.20 ? 69  THR H OG1 1 
ATOM   1216 C CG2 . THR B 2 69  ? 10.187  37.819 -8.651  1.00 17.88 ? 69  THR H CG2 1 
ATOM   1217 N N   . ILE B 2 70  ? 10.695  35.424 -6.508  1.00 12.71 ? 70  ILE H N   1 
ATOM   1218 C CA  . ILE B 2 70  ? 11.866  35.165 -5.671  1.00 13.32 ? 70  ILE H CA  1 
ATOM   1219 C C   . ILE B 2 70  ? 13.069  35.904 -6.249  1.00 12.40 ? 70  ILE H C   1 
ATOM   1220 O O   . ILE B 2 70  ? 13.201  36.075 -7.473  1.00 13.10 ? 70  ILE H O   1 
ATOM   1221 C CB  . ILE B 2 70  ? 12.124  33.642 -5.559  1.00 11.54 ? 70  ILE H CB  1 
ATOM   1222 C CG1 . ILE B 2 70  ? 13.134  33.331 -4.453  1.00 12.88 ? 70  ILE H CG1 1 
ATOM   1223 C CG2 . ILE B 2 70  ? 12.573  33.081 -6.882  1.00 10.48 ? 70  ILE H CG2 1 
ATOM   1224 C CD1 . ILE B 2 70  ? 13.317  31.808 -4.201  1.00 10.57 ? 70  ILE H CD1 1 
ATOM   1225 N N   . SER B 2 71  ? 13.946  36.378 -5.367  1.00 10.62 ? 71  SER H N   1 
ATOM   1226 C CA  . SER B 2 71  ? 15.211  36.957 -5.808  1.00 12.50 ? 71  SER H CA  1 
ATOM   1227 C C   . SER B 2 71  ? 16.226  36.758 -4.697  1.00 12.84 ? 71  SER H C   1 
ATOM   1228 O O   . SER B 2 71  ? 15.883  36.348 -3.578  1.00 13.18 ? 71  SER H O   1 
ATOM   1229 C CB  . SER B 2 71  ? 15.060  38.438 -6.190  1.00 13.58 ? 71  SER H CB  1 
ATOM   1230 O OG  . SER B 2 71  ? 14.605  39.221 -5.093  1.00 16.16 ? 71  SER H OG  1 
ATOM   1231 N N   . ARG B 2 72  ? 17.489  37.018 -5.023  1.00 11.67 ? 72  ARG H N   1 
ATOM   1232 C CA  . ARG B 2 72  ? 18.561  36.925 -4.044  1.00 13.59 ? 72  ARG H CA  1 
ATOM   1233 C C   . ARG B 2 72  ? 19.590  38.008 -4.327  1.00 13.47 ? 72  ARG H C   1 
ATOM   1234 O O   . ARG B 2 72  ? 19.775  38.419 -5.475  1.00 13.66 ? 72  ARG H O   1 
ATOM   1235 C CB  . ARG B 2 72  ? 19.223  35.541 -4.067  1.00 14.44 ? 72  ARG H CB  1 
ATOM   1236 C CG  . ARG B 2 72  ? 20.044  35.234 -5.324  1.00 16.19 ? 72  ARG H CG  1 
ATOM   1237 C CD  . ARG B 2 72  ? 20.400  33.756 -5.355  1.00 17.50 ? 72  ARG H CD  1 
ATOM   1238 N NE  . ARG B 2 72  ? 21.239  33.376 -4.221  1.00 14.41 ? 72  ARG H NE  1 
ATOM   1239 C CZ  . ARG B 2 72  ? 21.407  32.128 -3.800  1.00 14.01 ? 72  ARG H CZ  1 
ATOM   1240 N NH1 . ARG B 2 72  ? 20.791  31.108 -4.386  1.00 13.78 ? 72  ARG H NH1 1 
ATOM   1241 N NH2 . ARG B 2 72  ? 22.211  31.896 -2.761  1.00 11.02 ? 72  ARG H NH2 1 
ATOM   1242 N N   . ASP B 2 73  ? 20.264  38.455 -3.267  1.00 15.46 ? 73  ASP H N   1 
ATOM   1243 C CA  . ASP B 2 73  ? 21.381  39.398 -3.357  1.00 16.13 ? 73  ASP H CA  1 
ATOM   1244 C C   . ASP B 2 73  ? 22.595  38.694 -2.761  1.00 18.00 ? 73  ASP H C   1 
ATOM   1245 O O   . ASP B 2 73  ? 22.669  38.503 -1.543  1.00 19.36 ? 73  ASP H O   1 
ATOM   1246 C CB  . ASP B 2 73  ? 21.038  40.691 -2.612  1.00 19.76 ? 73  ASP H CB  1 
ATOM   1247 C CG  . ASP B 2 73  ? 22.154  41.717 -2.643  1.00 26.40 ? 73  ASP H CG  1 
ATOM   1248 O OD1 . ASP B 2 73  ? 23.303  41.375 -3.001  1.00 24.48 ? 73  ASP H OD1 1 
ATOM   1249 O OD2 . ASP B 2 73  ? 21.858  42.888 -2.313  1.00 26.72 ? 73  ASP H OD2 1 
ATOM   1250 N N   . ASN B 2 74  ? 23.530  38.278 -3.607  1.00 18.33 ? 74  ASN H N   1 
ATOM   1251 C CA  . ASN B 2 74  ? 24.633  37.480 -3.092  1.00 16.58 ? 74  ASN H CA  1 
ATOM   1252 C C   . ASN B 2 74  ? 25.720  38.315 -2.434  1.00 22.77 ? 74  ASN H C   1 
ATOM   1253 O O   . ASN B 2 74  ? 26.709  37.745 -1.970  1.00 22.29 ? 74  ASN H O   1 
ATOM   1254 C CB  . ASN B 2 74  ? 25.223  36.621 -4.203  1.00 17.30 ? 74  ASN H CB  1 
ATOM   1255 C CG  . ASN B 2 74  ? 24.350  35.413 -4.525  1.00 20.95 ? 74  ASN H CG  1 
ATOM   1256 O OD1 . ASN B 2 74  ? 23.419  35.087 -3.777  1.00 18.20 ? 74  ASN H OD1 1 
ATOM   1257 N ND2 . ASN B 2 74  ? 24.642  34.750 -5.643  1.00 18.51 ? 74  ASN H ND2 1 
ATOM   1258 N N   . SER B 2 75  ? 25.567  39.639 -2.377  1.00 22.40 ? 75  SER H N   1 
ATOM   1259 C CA  . SER B 2 75  ? 26.451  40.506 -1.603  1.00 23.67 ? 75  SER H CA  1 
ATOM   1260 C C   . SER B 2 75  ? 25.904  40.765 -0.210  1.00 27.82 ? 75  SER H C   1 
ATOM   1261 O O   . SER B 2 75  ? 26.650  40.736 0.776   1.00 30.65 ? 75  SER H O   1 
ATOM   1262 C CB  . SER B 2 75  ? 26.669  41.842 -2.330  1.00 30.12 ? 75  SER H CB  1 
ATOM   1263 O OG  . SER B 2 75  ? 27.171  41.621 -3.640  1.00 27.58 ? 75  SER H OG  1 
ATOM   1264 N N   . LYS B 2 76  ? 24.605  41.029 -0.107  1.00 23.07 ? 76  LYS H N   1 
ATOM   1265 C CA  . LYS B 2 76  ? 23.991  41.119 1.205   1.00 27.59 ? 76  LYS H CA  1 
ATOM   1266 C C   . LYS B 2 76  ? 23.708  39.746 1.804   1.00 20.07 ? 76  LYS H C   1 
ATOM   1267 O O   . LYS B 2 76  ? 23.329  39.672 2.976   1.00 23.87 ? 76  LYS H O   1 
ATOM   1268 C CB  . LYS B 2 76  ? 22.697  41.925 1.140   1.00 25.05 ? 76  LYS H CB  1 
ATOM   1269 C CG  . LYS B 2 76  ? 22.890  43.414 0.888   1.00 31.76 ? 76  LYS H CG  1 
ATOM   1270 C CD  . LYS B 2 76  ? 21.635  44.221 1.226   1.00 32.68 ? 76  LYS H CD  1 
ATOM   1271 C CE  . LYS B 2 76  ? 21.478  44.428 2.733   1.00 38.39 ? 76  LYS H CE  1 
ATOM   1272 N N   . ASN B 2 77  ? 23.890  38.679 1.030   1.00 19.76 ? 77  ASN H N   1 
ATOM   1273 C CA  . ASN B 2 77  ? 23.592  37.321 1.467   1.00 18.91 ? 77  ASN H CA  1 
ATOM   1274 C C   . ASN B 2 77  ? 22.166  37.237 1.989   1.00 17.90 ? 77  ASN H C   1 
ATOM   1275 O O   . ASN B 2 77  ? 21.909  36.799 3.107   1.00 15.77 ? 77  ASN H O   1 
ATOM   1276 C CB  . ASN B 2 77  ? 24.602  36.853 2.515   1.00 17.79 ? 77  ASN H CB  1 
ATOM   1277 C CG  . ASN B 2 77  ? 25.914  36.414 1.894   1.00 21.03 ? 77  ASN H CG  1 
ATOM   1278 O OD1 . ASN B 2 77  ? 26.086  36.445 0.672   1.00 21.43 ? 77  ASN H OD1 1 
ATOM   1279 N ND2 . ASN B 2 77  ? 26.846  35.988 2.733   1.00 25.77 ? 77  ASN H ND2 1 
ATOM   1280 N N   . THR B 2 78  ? 21.231  37.695 1.173   1.00 16.10 ? 78  THR H N   1 
ATOM   1281 C CA  . THR B 2 78  ? 19.837  37.772 1.572   1.00 14.23 ? 78  THR H CA  1 
ATOM   1282 C C   . THR B 2 78  ? 18.980  37.163 0.481   1.00 15.27 ? 78  THR H C   1 
ATOM   1283 O O   . THR B 2 78  ? 19.284  37.315 -0.706  1.00 12.40 ? 78  THR H O   1 
ATOM   1284 C CB  . THR B 2 78  ? 19.429  39.215 1.817   1.00 17.97 ? 78  THR H CB  1 
ATOM   1285 O OG1 . THR B 2 78  ? 20.356  39.809 2.737   1.00 20.93 ? 78  THR H OG1 1 
ATOM   1286 C CG2 . THR B 2 78  ? 18.020  39.284 2.380   1.00 17.44 ? 78  THR H CG2 1 
ATOM   1287 N N   . LEU B 2 79  ? 17.929  36.455 0.901   1.00 14.97 ? 79  LEU H N   1 
ATOM   1288 C CA  . LEU B 2 79  ? 16.914  35.896 0.023   1.00 13.48 ? 79  LEU H CA  1 
ATOM   1289 C C   . LEU B 2 79  ? 15.650  36.724 0.179   1.00 11.50 ? 79  LEU H C   1 
ATOM   1290 O O   . LEU B 2 79  ? 15.331  37.156 1.287   1.00 13.84 ? 79  LEU H O   1 
ATOM   1291 C CB  . LEU B 2 79  ? 16.644  34.431 0.380   1.00 12.01 ? 79  LEU H CB  1 
ATOM   1292 C CG  . LEU B 2 79  ? 15.641  33.664 -0.475  1.00 11.49 ? 79  LEU H CG  1 
ATOM   1293 C CD1 . LEU B 2 79  ? 16.278  33.395 -1.822  1.00 13.23 ? 79  LEU H CD1 1 
ATOM   1294 C CD2 . LEU B 2 79  ? 15.269  32.348 0.209   1.00 10.46 ? 79  LEU H CD2 1 
ATOM   1295 N N   . TYR B 2 80  ? 14.926  36.952 -0.923  1.00 12.33 ? 80  TYR H N   1 
ATOM   1296 C CA  . TYR B 2 80  ? 13.703  37.741 -0.878  1.00 11.92 ? 80  TYR H CA  1 
ATOM   1297 C C   . TYR B 2 80  ? 12.521  36.978 -1.457  1.00 12.34 ? 80  TYR H C   1 
ATOM   1298 O O   . TYR B 2 80  ? 12.673  36.160 -2.371  1.00 13.97 ? 80  TYR H O   1 
ATOM   1299 C CB  . TYR B 2 80  ? 13.861  39.063 -1.645  1.00 15.52 ? 80  TYR H CB  1 
ATOM   1300 C CG  . TYR B 2 80  ? 14.992  39.900 -1.127  1.00 14.34 ? 80  TYR H CG  1 
ATOM   1301 C CD1 . TYR B 2 80  ? 14.860  40.636 0.057   1.00 19.62 ? 80  TYR H CD1 1 
ATOM   1302 C CD2 . TYR B 2 80  ? 16.203  39.947 -1.798  1.00 18.95 ? 80  TYR H CD2 1 
ATOM   1303 C CE1 . TYR B 2 80  ? 15.921  41.413 0.547   1.00 18.17 ? 80  TYR H CE1 1 
ATOM   1304 C CE2 . TYR B 2 80  ? 17.263  40.717 -1.319  1.00 16.42 ? 80  TYR H CE2 1 
ATOM   1305 C CZ  . TYR B 2 80  ? 17.110  41.439 -0.148  1.00 20.36 ? 80  TYR H CZ  1 
ATOM   1306 O OH  . TYR B 2 80  ? 18.160  42.192 0.318   1.00 26.67 ? 80  TYR H OH  1 
ATOM   1307 N N   . LEU B 2 81  ? 11.336  37.259 -0.920  1.00 11.74 ? 81  LEU H N   1 
ATOM   1308 C CA  . LEU B 2 81  ? 10.083  36.810 -1.514  1.00 12.30 ? 81  LEU H CA  1 
ATOM   1309 C C   . LEU B 2 81  ? 9.181   38.025 -1.645  1.00 13.88 ? 81  LEU H C   1 
ATOM   1310 O O   . LEU B 2 81  ? 8.793   38.621 -0.637  1.00 13.04 ? 81  LEU H O   1 
ATOM   1311 C CB  . LEU B 2 81  ? 9.405   35.711 -0.683  1.00 13.05 ? 81  LEU H CB  1 
ATOM   1312 C CG  . LEU B 2 81  ? 8.095   35.164 -1.269  1.00 14.81 ? 81  LEU H CG  1 
ATOM   1313 C CD1 . LEU B 2 81  ? 8.350   34.445 -2.588  1.00 12.61 ? 81  LEU H CD1 1 
ATOM   1314 C CD2 . LEU B 2 81  ? 7.368   34.246 -0.311  1.00 12.05 ? 81  LEU H CD2 1 
ATOM   1315 N N   . GLN B 2 82  ? 8.873   38.403 -2.880  1.00 12.59 ? 82  GLN H N   1 
ATOM   1316 C CA  . GLN B 2 82  ? 7.949   39.495 -3.168  1.00 13.55 ? 82  GLN H CA  1 
ATOM   1317 C C   . GLN B 2 82  ? 6.584   38.882 -3.462  1.00 14.94 ? 82  GLN H C   1 
ATOM   1318 O O   . GLN B 2 82  ? 6.407   38.202 -4.477  1.00 15.11 ? 82  GLN H O   1 
ATOM   1319 C CB  . GLN B 2 82  ? 8.438   40.332 -4.349  1.00 16.58 ? 82  GLN H CB  1 
ATOM   1320 C CG  . GLN B 2 82  ? 7.464   41.432 -4.722  1.00 18.44 ? 82  GLN H CG  1 
ATOM   1321 C CD  . GLN B 2 82  ? 7.366   42.480 -3.635  1.00 18.77 ? 82  GLN H CD  1 
ATOM   1322 O OE1 . GLN B 2 82  ? 8.384   42.939 -3.122  1.00 20.71 ? 82  GLN H OE1 1 
ATOM   1323 N NE2 . GLN B 2 82  ? 6.140   42.857 -3.267  1.00 21.56 ? 82  GLN H NE2 1 
ATOM   1324 N N   . MET B 2 83  ? 5.628   39.109 -2.576  1.00 14.93 ? 83  MET H N   1 
ATOM   1325 C CA  . MET B 2 83  ? 4.306   38.501 -2.667  1.00 15.85 ? 83  MET H CA  1 
ATOM   1326 C C   . MET B 2 83  ? 3.306   39.546 -3.144  1.00 18.05 ? 83  MET H C   1 
ATOM   1327 O O   . MET B 2 83  ? 3.134   40.572 -2.489  1.00 21.51 ? 83  MET H O   1 
ATOM   1328 C CB  . MET B 2 83  ? 3.882   37.944 -1.309  1.00 16.87 ? 83  MET H CB  1 
ATOM   1329 C CG  . MET B 2 83  ? 4.695   36.746 -0.844  1.00 17.89 ? 83  MET H CG  1 
ATOM   1330 S SD  . MET B 2 83  ? 4.045   36.073 0.704   1.00 29.44 ? 83  MET H SD  1 
ATOM   1331 C CE  . MET B 2 83  ? 4.609   37.302 1.778   1.00 8.64  ? 83  MET H CE  1 
ATOM   1332 N N   . ASN B 2 84  ? 2.650   39.286 -4.270  1.00 20.88 ? 84  ASN H N   1 
ATOM   1333 C CA  . ASN B 2 84  ? 1.596   40.161 -4.769  1.00 17.62 ? 84  ASN H CA  1 
ATOM   1334 C C   . ASN B 2 84  ? 0.299   39.372 -4.889  1.00 18.67 ? 84  ASN H C   1 
ATOM   1335 O O   . ASN B 2 84  ? 0.283   38.141 -4.783  1.00 16.94 ? 84  ASN H O   1 
ATOM   1336 C CB  . ASN B 2 84  ? 1.966   40.774 -6.129  1.00 19.48 ? 84  ASN H CB  1 
ATOM   1337 C CG  . ASN B 2 84  ? 3.384   41.337 -6.164  1.00 21.34 ? 84  ASN H CG  1 
ATOM   1338 O OD1 . ASN B 2 84  ? 3.688   42.344 -5.527  1.00 23.24 ? 84  ASN H OD1 1 
ATOM   1339 N ND2 . ASN B 2 84  ? 4.259   40.684 -6.927  1.00 22.59 ? 84  ASN H ND2 1 
ATOM   1340 N N   . SER B 2 85  ? -0.795  40.094 -5.142  1.00 17.11 ? 85  SER H N   1 
ATOM   1341 C CA  . SER B 2 85  ? -2.096  39.473 -5.376  1.00 19.18 ? 85  SER H CA  1 
ATOM   1342 C C   . SER B 2 85  ? -2.422  38.480 -4.271  1.00 15.54 ? 85  SER H C   1 
ATOM   1343 O O   . SER B 2 85  ? -2.852  37.364 -4.525  1.00 14.96 ? 85  SER H O   1 
ATOM   1344 C CB  . SER B 2 85  ? -2.139  38.781 -6.737  1.00 21.66 ? 85  SER H CB  1 
ATOM   1345 O OG  . SER B 2 85  ? -1.892  39.702 -7.788  1.00 26.80 ? 85  SER H OG  1 
ATOM   1346 N N   . LEU B 2 86  ? -2.172  38.883 -3.031  1.00 18.49 ? 86  LEU H N   1 
ATOM   1347 C CA  . LEU B 2 86  ? -2.267  37.950 -1.914  1.00 15.41 ? 86  LEU H CA  1 
ATOM   1348 C C   . LEU B 2 86  ? -3.703  37.512 -1.655  1.00 14.20 ? 86  LEU H C   1 
ATOM   1349 O O   . LEU B 2 86  ? -4.654  38.288 -1.804  1.00 15.07 ? 86  LEU H O   1 
ATOM   1350 C CB  . LEU B 2 86  ? -1.662  38.586 -0.662  1.00 12.67 ? 86  LEU H CB  1 
ATOM   1351 C CG  . LEU B 2 86  ? -0.138  38.397 -0.666  1.00 16.24 ? 86  LEU H CG  1 
ATOM   1352 C CD1 . LEU B 2 86  ? 0.529   39.383 0.253   1.00 19.07 ? 86  LEU H CD1 1 
ATOM   1353 C CD2 . LEU B 2 86  ? 0.203   36.972 -0.271  1.00 14.21 ? 86  LEU H CD2 1 
ATOM   1354 N N   . ARG B 2 87  ? -3.854  36.253 -1.255  1.00 12.29 ? 87  ARG H N   1 
ATOM   1355 C CA  . ARG B 2 87  ? -5.139  35.615 -1.035  1.00 13.02 ? 87  ARG H CA  1 
ATOM   1356 C C   . ARG B 2 87  ? -5.165  35.011 0.362   1.00 16.84 ? 87  ARG H C   1 
ATOM   1357 O O   . ARG B 2 87  ? -4.121  34.762 0.976   1.00 14.92 ? 87  ARG H O   1 
ATOM   1358 C CB  . ARG B 2 87  ? -5.393  34.538 -2.094  1.00 15.68 ? 87  ARG H CB  1 
ATOM   1359 C CG  . ARG B 2 87  ? -5.413  35.088 -3.514  1.00 16.70 ? 87  ARG H CG  1 
ATOM   1360 C CD  . ARG B 2 87  ? -5.388  33.972 -4.522  1.00 18.12 ? 87  ARG H CD  1 
ATOM   1361 N NE  . ARG B 2 87  ? -6.575  33.137 -4.410  1.00 24.84 ? 87  ARG H NE  1 
ATOM   1362 C CZ  . ARG B 2 87  ? -7.739  33.412 -4.980  1.00 25.89 ? 87  ARG H CZ  1 
ATOM   1363 N NH1 . ARG B 2 87  ? -7.900  34.486 -5.738  1.00 24.44 ? 87  ARG H NH1 1 
ATOM   1364 N NH2 . ARG B 2 87  ? -8.768  32.591 -4.781  1.00 27.64 ? 87  ARG H NH2 1 
ATOM   1365 N N   . ALA B 2 88  ? -6.382  34.773 0.855   1.00 17.38 ? 88  ALA H N   1 
ATOM   1366 C CA  . ALA B 2 88  ? -6.549  34.229 2.197   1.00 16.04 ? 88  ALA H CA  1 
ATOM   1367 C C   . ALA B 2 88  ? -5.781  32.931 2.362   1.00 18.86 ? 88  ALA H C   1 
ATOM   1368 O O   . ALA B 2 88  ? -5.202  32.679 3.423   1.00 18.95 ? 88  ALA H O   1 
ATOM   1369 C CB  . ALA B 2 88  ? -8.036  34.002 2.505   1.00 20.50 ? 88  ALA H CB  1 
ATOM   1370 N N   . GLU B 2 89  ? -5.740  32.102 1.317   1.00 15.82 ? 89  GLU H N   1 
ATOM   1371 C CA  . GLU B 2 89  ? -5.041  30.826 1.400   1.00 17.99 ? 89  GLU H CA  1 
ATOM   1372 C C   . GLU B 2 89  ? -3.519  30.969 1.383   1.00 15.10 ? 89  GLU H C   1 
ATOM   1373 O O   . GLU B 2 89  ? -2.824  29.962 1.537   1.00 17.51 ? 89  GLU H O   1 
ATOM   1374 C CB  . GLU B 2 89  ? -5.497  29.922 0.259   1.00 20.09 ? 89  GLU H CB  1 
ATOM   1375 C CG  . GLU B 2 89  ? -5.199  30.493 -1.127  1.00 24.41 ? 89  GLU H CG  1 
ATOM   1376 C CD  . GLU B 2 89  ? -6.420  31.096 -1.829  1.00 27.15 ? 89  GLU H CD  1 
ATOM   1377 O OE1 . GLU B 2 89  ? -7.368  31.595 -1.147  1.00 23.31 ? 89  GLU H OE1 1 
ATOM   1378 O OE2 . GLU B 2 89  ? -6.424  31.062 -3.089  1.00 23.91 ? 89  GLU H OE2 1 
ATOM   1379 N N   . ASP B 2 90  ? -2.987  32.176 1.185   1.00 13.38 ? 90  ASP H N   1 
ATOM   1380 C CA  . ASP B 2 90  ? -1.559  32.434 1.345   1.00 13.63 ? 90  ASP H CA  1 
ATOM   1381 C C   . ASP B 2 90  ? -1.164  32.640 2.801   1.00 14.17 ? 90  ASP H C   1 
ATOM   1382 O O   . ASP B 2 90  ? 0.040   32.733 3.105   1.00 13.19 ? 90  ASP H O   1 
ATOM   1383 C CB  . ASP B 2 90  ? -1.149  33.651 0.518   1.00 14.20 ? 90  ASP H CB  1 
ATOM   1384 C CG  . ASP B 2 90  ? -1.379  33.448 -0.954  1.00 15.86 ? 90  ASP H CG  1 
ATOM   1385 O OD1 . ASP B 2 90  ? -1.135  32.317 -1.429  1.00 14.05 ? 90  ASP H OD1 1 
ATOM   1386 O OD2 . ASP B 2 90  ? -1.808  34.411 -1.637  1.00 17.26 ? 90  ASP H OD2 1 
ATOM   1387 N N   . THR B 2 91  ? -2.141  32.717 3.695   1.00 13.38 ? 91  THR H N   1 
ATOM   1388 C CA  . THR B 2 91  ? -1.859  32.785 5.118   1.00 12.14 ? 91  THR H CA  1 
ATOM   1389 C C   . THR B 2 91  ? -1.093  31.535 5.539   1.00 9.86  ? 91  THR H C   1 
ATOM   1390 O O   . THR B 2 91  ? -1.595  30.415 5.394   1.00 12.77 ? 91  THR H O   1 
ATOM   1391 C CB  . THR B 2 91  ? -3.176  32.921 5.893   1.00 13.11 ? 91  THR H CB  1 
ATOM   1392 O OG1 . THR B 2 91  ? -3.762  34.214 5.642   1.00 12.08 ? 91  THR H OG1 1 
ATOM   1393 C CG2 . THR B 2 91  ? -2.944  32.755 7.390   1.00 15.57 ? 91  THR H CG2 1 
ATOM   1394 N N   . ALA B 2 92  ? 0.130   31.723 6.035   1.00 10.30 ? 92  ALA H N   1 
ATOM   1395 C CA  . ALA B 2 92  ? 1.033   30.618 6.334   1.00 10.54 ? 92  ALA H CA  1 
ATOM   1396 C C   . ALA B 2 92  ? 2.277   31.151 7.037   1.00 9.93  ? 92  ALA H C   1 
ATOM   1397 O O   . ALA B 2 92  ? 2.579   32.346 6.994   1.00 8.08  ? 92  ALA H O   1 
ATOM   1398 C CB  . ALA B 2 92  ? 1.452   29.857 5.064   1.00 10.49 ? 92  ALA H CB  1 
ATOM   1399 N N   . ILE B 2 93  ? 2.990   30.238 7.689   1.00 9.74  ? 93  ILE H N   1 
ATOM   1400 C CA  . ILE B 2 93  ? 4.363   30.504 8.111   1.00 9.99  ? 93  ILE H CA  1 
ATOM   1401 C C   . ILE B 2 93  ? 5.258   30.292 6.901   1.00 11.42 ? 93  ILE H C   1 
ATOM   1402 O O   . ILE B 2 93  ? 5.155   29.269 6.210   1.00 11.02 ? 93  ILE H O   1 
ATOM   1403 C CB  . ILE B 2 93  ? 4.776   29.586 9.275   1.00 11.52 ? 93  ILE H CB  1 
ATOM   1404 C CG1 . ILE B 2 93  ? 3.914   29.856 10.522  1.00 13.70 ? 93  ILE H CG1 1 
ATOM   1405 C CG2 . ILE B 2 93  ? 6.273   29.749 9.589   1.00 13.35 ? 93  ILE H CG2 1 
ATOM   1406 C CD1 . ILE B 2 93  ? 4.082   28.770 11.612  1.00 16.30 ? 93  ILE H CD1 1 
ATOM   1407 N N   . TYR B 2 94  ? 6.118   31.258 6.623   1.00 8.83  ? 94  TYR H N   1 
ATOM   1408 C CA  . TYR B 2 94  ? 7.028   31.181 5.486   1.00 8.25  ? 94  TYR H CA  1 
ATOM   1409 C C   . TYR B 2 94  ? 8.443   30.937 6.003   1.00 11.39 ? 94  TYR H C   1 
ATOM   1410 O O   . TYR B 2 94  ? 8.994   31.776 6.734   1.00 12.33 ? 94  TYR H O   1 
ATOM   1411 C CB  . TYR B 2 94  ? 6.930   32.457 4.642   1.00 8.44  ? 94  TYR H CB  1 
ATOM   1412 C CG  . TYR B 2 94  ? 5.687   32.473 3.787   1.00 8.68  ? 94  TYR H CG  1 
ATOM   1413 C CD1 . TYR B 2 94  ? 4.437   32.718 4.347   1.00 10.11 ? 94  TYR H CD1 1 
ATOM   1414 C CD2 . TYR B 2 94  ? 5.756   32.213 2.412   1.00 10.14 ? 94  TYR H CD2 1 
ATOM   1415 C CE1 . TYR B 2 94  ? 3.285   32.722 3.573   1.00 10.03 ? 94  TYR H CE1 1 
ATOM   1416 C CE2 . TYR B 2 94  ? 4.605   32.200 1.634   1.00 11.60 ? 94  TYR H CE2 1 
ATOM   1417 C CZ  . TYR B 2 94  ? 3.383   32.458 2.211   1.00 10.64 ? 94  TYR H CZ  1 
ATOM   1418 O OH  . TYR B 2 94  ? 2.224   32.452 1.451   1.00 11.96 ? 94  TYR H OH  1 
ATOM   1419 N N   . TYR B 2 95  ? 9.004   29.778 5.639   1.00 9.08  ? 95  TYR H N   1 
ATOM   1420 C CA  . TYR B 2 95  ? 10.369  29.376 5.972   1.00 10.35 ? 95  TYR H CA  1 
ATOM   1421 C C   . TYR B 2 95  ? 11.312  29.595 4.799   1.00 9.90  ? 95  TYR H C   1 
ATOM   1422 O O   . TYR B 2 95  ? 10.987  29.266 3.652   1.00 12.05 ? 95  TYR H O   1 
ATOM   1423 C CB  . TYR B 2 95  ? 10.458  27.894 6.351   1.00 10.90 ? 95  TYR H CB  1 
ATOM   1424 C CG  . TYR B 2 95  ? 9.544   27.441 7.453   1.00 11.13 ? 95  TYR H CG  1 
ATOM   1425 C CD1 . TYR B 2 95  ? 9.898   27.617 8.792   1.00 13.45 ? 95  TYR H CD1 1 
ATOM   1426 C CD2 . TYR B 2 95  ? 8.343   26.805 7.157   1.00 12.84 ? 95  TYR H CD2 1 
ATOM   1427 C CE1 . TYR B 2 95  ? 9.050   27.190 9.806   1.00 16.81 ? 95  TYR H CE1 1 
ATOM   1428 C CE2 . TYR B 2 95  ? 7.489   26.382 8.169   1.00 13.88 ? 95  TYR H CE2 1 
ATOM   1429 C CZ  . TYR B 2 95  ? 7.855   26.573 9.488   1.00 16.03 ? 95  TYR H CZ  1 
ATOM   1430 O OH  . TYR B 2 95  ? 7.003   26.127 10.481  1.00 17.56 ? 95  TYR H OH  1 
ATOM   1431 N N   . CYS B 2 96  ? 12.505  30.084 5.126   1.00 9.37  ? 96  CYS H N   1 
ATOM   1432 C CA  . CYS B 2 96  ? 13.681  30.095 4.273   1.00 9.83  ? 96  CYS H CA  1 
ATOM   1433 C C   . CYS B 2 96  ? 14.457  28.794 4.476   1.00 12.13 ? 96  CYS H C   1 
ATOM   1434 O O   . CYS B 2 96  ? 14.676  28.373 5.617   1.00 10.71 ? 96  CYS H O   1 
ATOM   1435 C CB  . CYS B 2 96  ? 14.523  31.306 4.672   1.00 12.97 ? 96  CYS H CB  1 
ATOM   1436 S SG  . CYS B 2 96  ? 16.026  31.553 3.864   1.00 22.03 ? 96  CYS H SG  1 
ATOM   1437 N N   . ALA B 2 97  ? 14.862  28.144 3.385   1.00 11.69 ? 97  ALA H N   1 
ATOM   1438 C CA  . ALA B 2 97  ? 15.581  26.878 3.504   1.00 10.54 ? 97  ALA H CA  1 
ATOM   1439 C C   . ALA B 2 97  ? 16.765  26.821 2.546   1.00 12.73 ? 97  ALA H C   1 
ATOM   1440 O O   . ALA B 2 97  ? 16.659  27.240 1.391   1.00 11.13 ? 97  ALA H O   1 
ATOM   1441 C CB  . ALA B 2 97  ? 14.645  25.689 3.237   1.00 12.63 ? 97  ALA H CB  1 
ATOM   1442 N N   . ARG B 2 98  ? 17.887  26.279 3.026   1.00 10.50 ? 98  ARG H N   1 
ATOM   1443 C CA  . ARG B 2 98  ? 19.080  26.071 2.212   1.00 11.90 ? 98  ARG H CA  1 
ATOM   1444 C C   . ARG B 2 98  ? 19.082  24.668 1.614   1.00 11.51 ? 98  ARG H C   1 
ATOM   1445 O O   . ARG B 2 98  ? 18.694  23.700 2.275   1.00 12.20 ? 98  ARG H O   1 
ATOM   1446 C CB  . ARG B 2 98  ? 20.341  26.256 3.052   1.00 10.18 ? 98  ARG H CB  1 
ATOM   1447 C CG  . ARG B 2 98  ? 21.625  26.272 2.223   1.00 9.94  ? 98  ARG H CG  1 
ATOM   1448 C CD  . ARG B 2 98  ? 22.873  26.282 3.088   1.00 11.43 ? 98  ARG H CD  1 
ATOM   1449 N NE  . ARG B 2 98  ? 23.236  24.962 3.587   1.00 11.35 ? 98  ARG H NE  1 
ATOM   1450 C CZ  . ARG B 2 98  ? 24.399  24.709 4.172   1.00 13.57 ? 98  ARG H CZ  1 
ATOM   1451 N NH1 . ARG B 2 98  ? 25.310  25.660 4.330   1.00 14.41 ? 98  ARG H NH1 1 
ATOM   1452 N NH2 . ARG B 2 98  ? 24.662  23.475 4.589   1.00 14.20 ? 98  ARG H NH2 1 
ATOM   1453 N N   . THR B 2 99  ? 19.522  24.553 0.364   1.00 10.19 ? 99  THR H N   1 
ATOM   1454 C CA  . THR B 2 99  ? 19.698  23.242 -0.246  1.00 10.51 ? 99  THR H CA  1 
ATOM   1455 C C   . THR B 2 99  ? 21.136  22.786 -0.043  1.00 11.24 ? 99  THR H C   1 
ATOM   1456 O O   . THR B 2 99  ? 22.068  23.441 -0.527  1.00 9.33  ? 99  THR H O   1 
ATOM   1457 C CB  . THR B 2 99  ? 19.379  23.264 -1.746  1.00 10.14 ? 99  THR H CB  1 
ATOM   1458 O OG1 . THR B 2 99  ? 18.142  23.945 -1.996  1.00 8.77  ? 99  THR H OG1 1 
ATOM   1459 C CG2 . THR B 2 99  ? 19.275  21.841 -2.269  1.00 13.09 ? 99  THR H CG2 1 
ATOM   1460 N N   . GLY B 2 100 ? 21.321  21.659 0.647   1.00 10.82 ? 100 GLY H N   1 
ATOM   1461 C CA  . GLY B 2 100 ? 22.640  21.054 0.708   1.00 11.72 ? 100 GLY H CA  1 
ATOM   1462 C C   . GLY B 2 100 ? 23.164  20.705 -0.672  1.00 10.81 ? 100 GLY H C   1 
ATOM   1463 O O   . GLY B 2 100 ? 22.411  20.514 -1.629  1.00 11.19 ? 100 GLY H O   1 
ATOM   1464 N N   . TRP B 2 101 ? 24.490  20.627 -0.780  1.00 11.74 ? 101 TRP H N   1 
ATOM   1465 C CA  . TRP B 2 101 ? 25.085  20.301 -2.075  1.00 11.18 ? 101 TRP H CA  1 
ATOM   1466 C C   . TRP B 2 101 ? 24.669  18.926 -2.568  1.00 12.49 ? 101 TRP H C   1 
ATOM   1467 O O   . TRP B 2 101 ? 24.671  18.689 -3.781  1.00 14.64 ? 101 TRP H O   1 
ATOM   1468 C CB  . TRP B 2 101 ? 26.610  20.375 -2.002  1.00 13.34 ? 101 TRP H CB  1 
ATOM   1469 C CG  . TRP B 2 101 ? 27.127  21.756 -1.897  1.00 13.06 ? 101 TRP H CG  1 
ATOM   1470 C CD1 . TRP B 2 101 ? 26.441  22.913 -2.146  1.00 13.99 ? 101 TRP H CD1 1 
ATOM   1471 C CD2 . TRP B 2 101 ? 28.453  22.146 -1.515  1.00 15.55 ? 101 TRP H CD2 1 
ATOM   1472 N NE1 . TRP B 2 101 ? 27.266  24.001 -1.943  1.00 15.41 ? 101 TRP H NE1 1 
ATOM   1473 C CE2 . TRP B 2 101 ? 28.500  23.554 -1.545  1.00 13.80 ? 101 TRP H CE2 1 
ATOM   1474 C CE3 . TRP B 2 101 ? 29.598  21.443 -1.136  1.00 19.51 ? 101 TRP H CE3 1 
ATOM   1475 C CZ2 . TRP B 2 101 ? 29.655  24.271 -1.224  1.00 19.06 ? 101 TRP H CZ2 1 
ATOM   1476 C CZ3 . TRP B 2 101 ? 30.746  22.159 -0.811  1.00 20.10 ? 101 TRP H CZ3 1 
ATOM   1477 C CH2 . TRP B 2 101 ? 30.761  23.556 -0.855  1.00 21.07 ? 101 TRP H CH2 1 
ATOM   1478 N N   . LEU B 2 102 ? 24.283  18.014 -1.674  1.00 11.26 ? 102 LEU H N   1 
ATOM   1479 C CA  . LEU B 2 102 ? 23.761  16.728 -2.105  1.00 11.43 ? 102 LEU H CA  1 
ATOM   1480 C C   . LEU B 2 102 ? 22.244  16.725 -2.298  1.00 12.01 ? 102 LEU H C   1 
ATOM   1481 O O   . LEU B 2 102 ? 21.672  15.671 -2.608  1.00 13.67 ? 102 LEU H O   1 
ATOM   1482 C CB  . LEU B 2 102 ? 24.177  15.631 -1.116  1.00 12.78 ? 102 LEU H CB  1 
ATOM   1483 C CG  . LEU B 2 102 ? 25.692  15.528 -0.954  1.00 13.07 ? 102 LEU H CG  1 
ATOM   1484 C CD1 . LEU B 2 102 ? 26.087  14.547 0.140   1.00 17.97 ? 102 LEU H CD1 1 
ATOM   1485 C CD2 . LEU B 2 102 ? 26.300  15.122 -2.279  1.00 13.01 ? 102 LEU H CD2 1 
ATOM   1486 N N   . GLY B 2 103 ? 21.571  17.864 -2.152  1.00 11.29 ? 103 GLY H N   1 
ATOM   1487 C CA  . GLY B 2 103 ? 20.183  17.923 -2.565  1.00 11.48 ? 103 GLY H CA  1 
ATOM   1488 C C   . GLY B 2 103 ? 19.071  18.235 -1.568  1.00 9.17  ? 103 GLY H C   1 
ATOM   1489 O O   . GLY B 2 103 ? 18.065  18.851 -1.945  1.00 11.11 ? 103 GLY H O   1 
ATOM   1490 N N   . PRO B 2 104 ? 19.156  17.785 -0.314  1.00 12.02 ? 104 PRO H N   1 
ATOM   1491 C CA  . PRO B 2 104 ? 18.037  18.005 0.612   1.00 10.61 ? 104 PRO H CA  1 
ATOM   1492 C C   . PRO B 2 104 ? 18.053  19.415 1.195   1.00 11.79 ? 104 PRO H C   1 
ATOM   1493 O O   . PRO B 2 104 ? 19.017  20.166 1.070   1.00 11.94 ? 104 PRO H O   1 
ATOM   1494 C CB  . PRO B 2 104 ? 18.280  16.957 1.702   1.00 11.32 ? 104 PRO H CB  1 
ATOM   1495 C CG  . PRO B 2 104 ? 19.763  16.908 1.769   1.00 11.33 ? 104 PRO H CG  1 
ATOM   1496 C CD  . PRO B 2 104 ? 20.247  17.057 0.353   1.00 12.57 ? 104 PRO H CD  1 
ATOM   1497 N N   . PHE B 2 105 ? 16.964  19.766 1.861   1.00 9.63  ? 105 PHE H N   1 
ATOM   1498 C CA  . PHE B 2 105 ? 16.874  21.073 2.511   1.00 7.37  ? 105 PHE H CA  1 
ATOM   1499 C C   . PHE B 2 105 ? 17.511  20.929 3.892   1.00 10.67 ? 105 PHE H C   1 
ATOM   1500 O O   . PHE B 2 105 ? 16.853  20.489 4.849   1.00 11.39 ? 105 PHE H O   1 
ATOM   1501 C CB  . PHE B 2 105 ? 15.429  21.560 2.610   1.00 9.93  ? 105 PHE H CB  1 
ATOM   1502 C CG  . PHE B 2 105 ? 14.749  21.844 1.270   1.00 11.95 ? 105 PHE H CG  1 
ATOM   1503 C CD1 . PHE B 2 105 ? 15.361  21.557 0.046   1.00 10.39 ? 105 PHE H CD1 1 
ATOM   1504 C CD2 . PHE B 2 105 ? 13.478  22.410 1.256   1.00 9.94  ? 105 PHE H CD2 1 
ATOM   1505 C CE1 . PHE B 2 105 ? 14.708  21.828 -1.171  1.00 10.11 ? 105 PHE H CE1 1 
ATOM   1506 C CE2 . PHE B 2 105 ? 12.811  22.676 0.051   1.00 12.25 ? 105 PHE H CE2 1 
ATOM   1507 C CZ  . PHE B 2 105 ? 13.435  22.398 -1.168  1.00 10.24 ? 105 PHE H CZ  1 
ATOM   1508 N N   . ASP B 2 106 ? 18.800  21.274 4.004   1.00 11.38 ? 106 ASP H N   1 
ATOM   1509 C CA  . ASP B 2 106 ? 19.560  20.859 5.185   1.00 11.71 ? 106 ASP H CA  1 
ATOM   1510 C C   . ASP B 2 106 ? 19.532  21.875 6.321   1.00 12.13 ? 106 ASP H C   1 
ATOM   1511 O O   . ASP B 2 106 ? 19.859  21.506 7.459   1.00 12.23 ? 106 ASP H O   1 
ATOM   1512 C CB  . ASP B 2 106 ? 21.008  20.489 4.807   1.00 12.94 ? 106 ASP H CB  1 
ATOM   1513 C CG  . ASP B 2 106 ? 21.807  21.644 4.185   1.00 11.53 ? 106 ASP H CG  1 
ATOM   1514 O OD1 . ASP B 2 106 ? 21.264  22.728 3.910   1.00 13.12 ? 106 ASP H OD1 1 
ATOM   1515 O OD2 . ASP B 2 106 ? 23.011  21.446 3.970   1.00 14.52 ? 106 ASP H OD2 1 
ATOM   1516 N N   . TYR B 2 107 ? 19.099  23.116 6.068   1.00 12.68 ? 107 TYR H N   1 
ATOM   1517 C CA  . TYR B 2 107 ? 18.903  24.114 7.118   1.00 14.12 ? 107 TYR H CA  1 
ATOM   1518 C C   . TYR B 2 107 ? 17.656  24.930 6.824   1.00 13.57 ? 107 TYR H C   1 
ATOM   1519 O O   . TYR B 2 107 ? 17.418  25.321 5.672   1.00 12.03 ? 107 TYR H O   1 
ATOM   1520 C CB  . TYR B 2 107 ? 20.121  25.055 7.271   1.00 12.12 ? 107 TYR H CB  1 
ATOM   1521 C CG  . TYR B 2 107 ? 21.301  24.361 7.912   1.00 17.67 ? 107 TYR H CG  1 
ATOM   1522 C CD1 . TYR B 2 107 ? 22.294  23.778 7.132   1.00 17.01 ? 107 TYR H CD1 1 
ATOM   1523 C CD2 . TYR B 2 107 ? 21.394  24.241 9.300   1.00 19.14 ? 107 TYR H CD2 1 
ATOM   1524 C CE1 . TYR B 2 107 ? 23.368  23.117 7.708   1.00 17.10 ? 107 TYR H CE1 1 
ATOM   1525 C CE2 . TYR B 2 107 ? 22.468  23.581 9.886   1.00 20.66 ? 107 TYR H CE2 1 
ATOM   1526 C CZ  . TYR B 2 107 ? 23.446  23.023 9.081   1.00 24.96 ? 107 TYR H CZ  1 
ATOM   1527 O OH  . TYR B 2 107 ? 24.510  22.357 9.644   1.00 24.71 ? 107 TYR H OH  1 
ATOM   1528 N N   . TRP B 2 108 ? 16.867  25.187 7.877   1.00 10.44 ? 108 TRP H N   1 
ATOM   1529 C CA  . TRP B 2 108 ? 15.621  25.937 7.786   1.00 12.18 ? 108 TRP H CA  1 
ATOM   1530 C C   . TRP B 2 108 ? 15.628  27.082 8.789   1.00 16.25 ? 108 TRP H C   1 
ATOM   1531 O O   . TRP B 2 108 ? 16.122  26.934 9.911   1.00 12.95 ? 108 TRP H O   1 
ATOM   1532 C CB  . TRP B 2 108 ? 14.419  25.054 8.077   1.00 15.11 ? 108 TRP H CB  1 
ATOM   1533 C CG  . TRP B 2 108 ? 14.202  23.892 7.159   1.00 11.62 ? 108 TRP H CG  1 
ATOM   1534 C CD1 . TRP B 2 108 ? 15.060  22.845 6.930   1.00 11.09 ? 108 TRP H CD1 1 
ATOM   1535 C CD2 . TRP B 2 108 ? 13.025  23.627 6.387   1.00 11.29 ? 108 TRP H CD2 1 
ATOM   1536 N NE1 . TRP B 2 108 ? 14.485  21.960 6.052   1.00 11.27 ? 108 TRP H NE1 1 
ATOM   1537 C CE2 . TRP B 2 108 ? 13.243  22.420 5.695   1.00 10.55 ? 108 TRP H CE2 1 
ATOM   1538 C CE3 . TRP B 2 108 ? 11.816  24.310 6.194   1.00 11.94 ? 108 TRP H CE3 1 
ATOM   1539 C CZ2 . TRP B 2 108 ? 12.294  21.867 4.828   1.00 11.46 ? 108 TRP H CZ2 1 
ATOM   1540 C CZ3 . TRP B 2 108 ? 10.860  23.755 5.334   1.00 10.89 ? 108 TRP H CZ3 1 
ATOM   1541 C CH2 . TRP B 2 108 ? 11.110  22.541 4.666   1.00 12.93 ? 108 TRP H CH2 1 
ATOM   1542 N N   . GLY B 2 109 ? 15.075  28.219 8.387   1.00 13.29 ? 109 GLY H N   1 
ATOM   1543 C CA  . GLY B 2 109 ? 14.845  29.289 9.326   1.00 11.80 ? 109 GLY H CA  1 
ATOM   1544 C C   . GLY B 2 109 ? 13.696  28.958 10.259  1.00 15.67 ? 109 GLY H C   1 
ATOM   1545 O O   . GLY B 2 109 ? 12.986  27.961 10.114  1.00 15.00 ? 109 GLY H O   1 
ATOM   1546 N N   . GLN B 2 110 ? 13.498  29.832 11.241  1.00 15.48 ? 110 GLN H N   1 
ATOM   1547 C CA  . GLN B 2 110 ? 12.391  29.656 12.169  1.00 15.90 ? 110 GLN H CA  1 
ATOM   1548 C C   . GLN B 2 110 ? 11.050  30.065 11.571  1.00 15.50 ? 110 GLN H C   1 
ATOM   1549 O O   . GLN B 2 110 ? 10.008  29.683 12.105  1.00 18.73 ? 110 GLN H O   1 
ATOM   1550 C CB  . GLN B 2 110 ? 12.668  30.443 13.446  1.00 23.53 ? 110 GLN H CB  1 
ATOM   1551 C CG  . GLN B 2 110 ? 12.914  29.562 14.680  1.00 28.87 ? 110 GLN H CG  1 
ATOM   1552 C CD  . GLN B 2 110 ? 13.649  28.261 14.367  1.00 32.54 ? 110 GLN H CD  1 
ATOM   1553 O OE1 . GLN B 2 110 ? 13.075  27.160 14.447  1.00 33.49 ? 110 GLN H OE1 1 
ATOM   1554 N NE2 . GLN B 2 110 ? 14.934  28.377 14.028  1.00 41.86 ? 110 GLN H NE2 1 
ATOM   1555 N N   . GLY B 2 111 ? 11.051  30.821 10.483  1.00 14.31 ? 111 GLY H N   1 
ATOM   1556 C CA  . GLY B 2 111 ? 9.837   31.185 9.766   1.00 14.78 ? 111 GLY H CA  1 
ATOM   1557 C C   . GLY B 2 111 ? 9.282   32.530 10.192  1.00 16.03 ? 111 GLY H C   1 
ATOM   1558 O O   . GLY B 2 111 ? 9.515   33.020 11.298  1.00 14.67 ? 111 GLY H O   1 
ATOM   1559 N N   . THR B 2 112 ? 8.531   33.145 9.284   1.00 12.68 ? 112 THR H N   1 
ATOM   1560 C CA  . THR B 2 112 ? 7.826   34.386 9.566   1.00 13.85 ? 112 THR H CA  1 
ATOM   1561 C C   . THR B 2 112 ? 6.385   34.224 9.110   1.00 14.09 ? 112 THR H C   1 
ATOM   1562 O O   . THR B 2 112 ? 6.127   33.651 8.046   1.00 11.64 ? 112 THR H O   1 
ATOM   1563 C CB  . THR B 2 112 ? 8.491   35.608 8.886   1.00 15.43 ? 112 THR H CB  1 
ATOM   1564 O OG1 . THR B 2 112 ? 7.808   36.800 9.291   1.00 16.05 ? 112 THR H OG1 1 
ATOM   1565 C CG2 . THR B 2 112 ? 8.451   35.526 7.358   1.00 14.50 ? 112 THR H CG2 1 
ATOM   1566 N N   . LEU B 2 113 ? 5.452   34.696 9.929   1.00 12.19 ? 113 LEU H N   1 
ATOM   1567 C CA  . LEU B 2 113 ? 4.032   34.442 9.702   1.00 12.62 ? 113 LEU H CA  1 
ATOM   1568 C C   . LEU B 2 113 ? 3.418   35.546 8.855   1.00 12.60 ? 113 LEU H C   1 
ATOM   1569 O O   . LEU B 2 113 ? 3.514   36.726 9.193   1.00 14.39 ? 113 LEU H O   1 
ATOM   1570 C CB  . LEU B 2 113 ? 3.280   34.338 11.028  1.00 15.36 ? 113 LEU H CB  1 
ATOM   1571 C CG  . LEU B 2 113 ? 1.760   34.210 10.919  1.00 14.53 ? 113 LEU H CG  1 
ATOM   1572 C CD1 . LEU B 2 113 ? 1.353   32.856 10.339  1.00 15.41 ? 113 LEU H CD1 1 
ATOM   1573 C CD2 . LEU B 2 113 ? 1.121   34.427 12.276  1.00 16.43 ? 113 LEU H CD2 1 
ATOM   1574 N N   . VAL B 2 114 ? 2.751   35.151 7.781   1.00 12.22 ? 114 VAL H N   1 
ATOM   1575 C CA  . VAL B 2 114 ? 1.985   36.058 6.944   1.00 12.05 ? 114 VAL H CA  1 
ATOM   1576 C C   . VAL B 2 114 ? 0.507   35.718 7.126   1.00 13.26 ? 114 VAL H C   1 
ATOM   1577 O O   . VAL B 2 114 ? 0.087   34.567 6.918   1.00 11.27 ? 114 VAL H O   1 
ATOM   1578 C CB  . VAL B 2 114 ? 2.420   35.953 5.473   1.00 10.93 ? 114 VAL H CB  1 
ATOM   1579 C CG1 . VAL B 2 114 ? 1.533   36.841 4.598   1.00 13.14 ? 114 VAL H CG1 1 
ATOM   1580 C CG2 . VAL B 2 114 ? 3.884   36.336 5.337   1.00 12.56 ? 114 VAL H CG2 1 
ATOM   1581 N N   . THR B 2 115 ? -0.277  36.710 7.535   1.00 13.54 ? 115 THR H N   1 
ATOM   1582 C CA  . THR B 2 115 ? -1.723  36.564 7.690   1.00 13.74 ? 115 THR H CA  1 
ATOM   1583 C C   . THR B 2 115 ? -2.432  37.501 6.716   1.00 13.87 ? 115 THR H C   1 
ATOM   1584 O O   . THR B 2 115 ? -2.278  38.723 6.793   1.00 15.01 ? 115 THR H O   1 
ATOM   1585 C CB  . THR B 2 115 ? -2.134  36.849 9.136   1.00 16.52 ? 115 THR H CB  1 
ATOM   1586 O OG1 . THR B 2 115 ? -1.432  35.947 10.004  1.00 15.61 ? 115 THR H OG1 1 
ATOM   1587 C CG2 . THR B 2 115 ? -3.646  36.682 9.322   1.00 15.27 ? 115 THR H CG2 1 
ATOM   1588 N N   . VAL B 2 116 ? -3.180  36.928 5.780   1.00 13.60 ? 116 VAL H N   1 
ATOM   1589 C CA  . VAL B 2 116 ? -3.878  37.700 4.760   1.00 13.45 ? 116 VAL H CA  1 
ATOM   1590 C C   . VAL B 2 116 ? -5.318  37.828 5.229   1.00 11.25 ? 116 VAL H C   1 
ATOM   1591 O O   . VAL B 2 116 ? -6.052  36.837 5.288   1.00 13.41 ? 116 VAL H O   1 
ATOM   1592 C CB  . VAL B 2 116 ? -3.788  37.039 3.375   1.00 13.59 ? 116 VAL H CB  1 
ATOM   1593 C CG1 . VAL B 2 116 ? -4.500  37.895 2.323   1.00 14.95 ? 116 VAL H CG1 1 
ATOM   1594 C CG2 . VAL B 2 116 ? -2.349  36.817 2.995   1.00 12.43 ? 116 VAL H CG2 1 
ATOM   1595 N N   . SER B 2 117 ? -5.730  39.043 5.586   1.00 13.46 ? 117 SER H N   1 
ATOM   1596 C CA  . SER B 2 117 ? -7.064  39.275 6.126   1.00 14.88 ? 117 SER H CA  1 
ATOM   1597 C C   . SER B 2 117 ? -7.482  40.705 5.843   1.00 13.28 ? 117 SER H C   1 
ATOM   1598 O O   . SER B 2 117 ? -6.667  41.624 5.912   1.00 12.92 ? 117 SER H O   1 
ATOM   1599 C CB  . SER B 2 117 ? -7.139  39.048 7.643   1.00 17.01 ? 117 SER H CB  1 
ATOM   1600 N N   . SER B 2 118 ? -8.764  40.889 5.570   1.00 12.68 ? 118 SER H N   1 
ATOM   1601 C CA  . SER B 2 118 ? -9.328  42.230 5.496   1.00 14.03 ? 118 SER H CA  1 
ATOM   1602 C C   . SER B 2 118 ? -9.888  42.698 6.836   1.00 18.81 ? 118 SER H C   1 
ATOM   1603 O O   . SER B 2 118 ? -10.485 43.778 6.903   1.00 17.16 ? 118 SER H O   1 
ATOM   1604 C CB  . SER B 2 118 ? -10.417 42.280 4.432   1.00 20.94 ? 118 SER H CB  1 
ATOM   1605 O OG  . SER B 2 118 ? -11.486 41.439 4.829   1.00 23.45 ? 118 SER H OG  1 
ATOM   1606 N N   . ALA B 2 119 ? -9.715  41.910 7.902   1.00 15.98 ? 119 ALA H N   1 
ATOM   1607 C CA  . ALA B 2 119 ? -10.312 42.262 9.180   1.00 16.45 ? 119 ALA H CA  1 
ATOM   1608 C C   . ALA B 2 119 ? -9.575  43.432 9.819   1.00 15.29 ? 119 ALA H C   1 
ATOM   1609 O O   . ALA B 2 119 ? -8.404  43.696 9.536   1.00 16.28 ? 119 ALA H O   1 
ATOM   1610 C CB  . ALA B 2 119 ? -10.303 41.062 10.128  1.00 15.07 ? 119 ALA H CB  1 
ATOM   1611 N N   . SER B 2 120 ? -10.278 44.139 10.704  1.00 17.76 ? 120 SER H N   1 
ATOM   1612 C CA  . SER B 2 120 ? -9.677  45.216 11.470  1.00 17.38 ? 120 SER H CA  1 
ATOM   1613 C C   . SER B 2 120 ? -9.684  44.859 12.953  1.00 19.66 ? 120 SER H C   1 
ATOM   1614 O O   . SER B 2 120 ? -10.378 43.936 13.391  1.00 18.11 ? 120 SER H O   1 
ATOM   1615 C CB  . SER B 2 120 ? -10.393 46.553 11.214  1.00 17.17 ? 120 SER H CB  1 
ATOM   1616 O OG  . SER B 2 120 ? -11.797 46.461 11.399  1.00 25.96 ? 120 SER H OG  1 
ATOM   1617 N N   . THR B 2 121 ? -8.878  45.597 13.715  1.00 16.81 ? 121 THR H N   1 
ATOM   1618 C CA  . THR B 2 121 ? -8.705  45.349 15.144  1.00 16.51 ? 121 THR H CA  1 
ATOM   1619 C C   . THR B 2 121 ? -10.034 45.390 15.896  1.00 19.51 ? 121 THR H C   1 
ATOM   1620 O O   . THR B 2 121 ? -10.818 46.337 15.760  1.00 17.72 ? 121 THR H O   1 
ATOM   1621 C CB  . THR B 2 121 ? -7.748  46.386 15.727  1.00 19.61 ? 121 THR H CB  1 
ATOM   1622 O OG1 . THR B 2 121 ? -6.471  46.271 15.082  1.00 21.83 ? 121 THR H OG1 1 
ATOM   1623 C CG2 . THR B 2 121 ? -7.589  46.168 17.215  1.00 19.35 ? 121 THR H CG2 1 
ATOM   1624 N N   . LYS B 2 122 ? -10.277 44.352 16.701  1.00 14.85 ? 122 LYS H N   1 
ATOM   1625 C CA  . LYS B 2 122 ? -11.489 44.266 17.507  1.00 15.80 ? 122 LYS H CA  1 
ATOM   1626 C C   . LYS B 2 122 ? -11.239 43.378 18.713  1.00 15.25 ? 122 LYS H C   1 
ATOM   1627 O O   . LYS B 2 122 ? -10.717 42.263 18.576  1.00 15.89 ? 122 LYS H O   1 
ATOM   1628 C CB  . LYS B 2 122 ? -12.672 43.714 16.713  1.00 17.34 ? 122 LYS H CB  1 
ATOM   1629 C CG  . LYS B 2 122 ? -13.971 43.678 17.534  1.00 19.33 ? 122 LYS H CG  1 
ATOM   1630 C CD  . LYS B 2 122 ? -15.134 43.158 16.717  1.00 18.74 ? 122 LYS H CD  1 
ATOM   1631 N N   . GLY B 2 123 ? -11.631 43.863 19.884  1.00 15.36 ? 123 GLY H N   1 
ATOM   1632 C CA  . GLY B 2 123 ? -11.550 43.063 21.077  1.00 16.09 ? 123 GLY H CA  1 
ATOM   1633 C C   . GLY B 2 123 ? -12.712 42.096 21.168  1.00 15.07 ? 123 GLY H C   1 
ATOM   1634 O O   . GLY B 2 123 ? -13.783 42.302 20.584  1.00 15.14 ? 123 GLY H O   1 
ATOM   1635 N N   . PRO B 2 124 ? -12.515 41.011 21.909  1.00 14.85 ? 124 PRO H N   1 
ATOM   1636 C CA  . PRO B 2 124 ? -13.562 40.001 22.043  1.00 13.97 ? 124 PRO H CA  1 
ATOM   1637 C C   . PRO B 2 124 ? -14.626 40.426 23.042  1.00 15.42 ? 124 PRO H C   1 
ATOM   1638 O O   . PRO B 2 124 ? -14.414 41.290 23.896  1.00 15.02 ? 124 PRO H O   1 
ATOM   1639 C CB  . PRO B 2 124 ? -12.795 38.778 22.560  1.00 15.56 ? 124 PRO H CB  1 
ATOM   1640 C CG  . PRO B 2 124 ? -11.712 39.378 23.389  1.00 14.92 ? 124 PRO H CG  1 
ATOM   1641 C CD  . PRO B 2 124 ? -11.292 40.638 22.632  1.00 14.43 ? 124 PRO H CD  1 
ATOM   1642 N N   . SER B 2 125 ? -15.788 39.793 22.916  1.00 14.94 ? 125 SER H N   1 
ATOM   1643 C CA  . SER B 2 125 ? -16.743 39.735 24.013  1.00 17.02 ? 125 SER H CA  1 
ATOM   1644 C C   . SER B 2 125 ? -16.572 38.385 24.705  1.00 17.14 ? 125 SER H C   1 
ATOM   1645 O O   . SER B 2 125 ? -16.281 37.377 24.057  1.00 17.56 ? 125 SER H O   1 
ATOM   1646 C CB  . SER B 2 125 ? -18.171 39.931 23.519  1.00 20.18 ? 125 SER H CB  1 
ATOM   1647 O OG  . SER B 2 125 ? -18.594 38.792 22.805  1.00 27.90 ? 125 SER H OG  1 
ATOM   1648 N N   . VAL B 2 126 ? -16.673 38.373 26.024  1.00 12.25 ? 126 VAL H N   1 
ATOM   1649 C CA  . VAL B 2 126 ? -16.397 37.168 26.798  1.00 15.82 ? 126 VAL H CA  1 
ATOM   1650 C C   . VAL B 2 126 ? -17.704 36.724 27.434  1.00 16.87 ? 126 VAL H C   1 
ATOM   1651 O O   . VAL B 2 126 ? -18.351 37.504 28.142  1.00 15.01 ? 126 VAL H O   1 
ATOM   1652 C CB  . VAL B 2 126 ? -15.320 37.408 27.865  1.00 19.02 ? 126 VAL H CB  1 
ATOM   1653 C CG1 . VAL B 2 126 ? -14.987 36.102 28.596  1.00 15.50 ? 126 VAL H CG1 1 
ATOM   1654 C CG2 . VAL B 2 126 ? -14.078 38.018 27.248  1.00 14.83 ? 126 VAL H CG2 1 
ATOM   1655 N N   . PHE B 2 127 ? -18.087 35.473 27.191  1.00 16.24 ? 127 PHE H N   1 
ATOM   1656 C CA  . PHE B 2 127 ? -19.342 34.960 27.711  1.00 16.33 ? 127 PHE H CA  1 
ATOM   1657 C C   . PHE B 2 127 ? -19.097 33.745 28.598  1.00 18.68 ? 127 PHE H C   1 
ATOM   1658 O O   . PHE B 2 127 ? -18.181 32.957 28.346  1.00 15.88 ? 127 PHE H O   1 
ATOM   1659 C CB  . PHE B 2 127 ? -20.298 34.560 26.580  1.00 15.74 ? 127 PHE H CB  1 
ATOM   1660 C CG  . PHE B 2 127 ? -20.586 35.659 25.597  1.00 18.29 ? 127 PHE H CG  1 
ATOM   1661 C CD1 . PHE B 2 127 ? -21.162 36.850 26.012  1.00 19.74 ? 127 PHE H CD1 1 
ATOM   1662 C CD2 . PHE B 2 127 ? -20.299 35.483 24.252  1.00 18.20 ? 127 PHE H CD2 1 
ATOM   1663 C CE1 . PHE B 2 127 ? -21.445 37.851 25.099  1.00 20.82 ? 127 PHE H CE1 1 
ATOM   1664 C CE2 . PHE B 2 127 ? -20.577 36.479 23.328  1.00 18.95 ? 127 PHE H CE2 1 
ATOM   1665 C CZ  . PHE B 2 127 ? -21.151 37.660 23.753  1.00 19.46 ? 127 PHE H CZ  1 
ATOM   1666 N N   . PRO B 2 128 ? -19.912 33.551 29.625  1.00 18.89 ? 128 PRO H N   1 
ATOM   1667 C CA  . PRO B 2 128 ? -19.740 32.375 30.478  1.00 19.16 ? 128 PRO H CA  1 
ATOM   1668 C C   . PRO B 2 128 ? -20.219 31.107 29.795  1.00 18.52 ? 128 PRO H C   1 
ATOM   1669 O O   . PRO B 2 128 ? -21.144 31.114 28.981  1.00 17.77 ? 128 PRO H O   1 
ATOM   1670 C CB  . PRO B 2 128 ? -20.610 32.704 31.694  1.00 20.09 ? 128 PRO H CB  1 
ATOM   1671 C CG  . PRO B 2 128 ? -21.697 33.549 31.120  1.00 21.43 ? 128 PRO H CG  1 
ATOM   1672 C CD  . PRO B 2 128 ? -21.047 34.389 30.065  1.00 18.83 ? 128 PRO H CD  1 
ATOM   1673 N N   . LEU B 2 129 ? -19.567 30.006 30.142  1.00 16.54 ? 129 LEU H N   1 
ATOM   1674 C CA  . LEU B 2 129 ? -20.015 28.657 29.804  1.00 16.63 ? 129 LEU H CA  1 
ATOM   1675 C C   . LEU B 2 129 ? -20.385 28.044 31.145  1.00 20.41 ? 129 LEU H C   1 
ATOM   1676 O O   . LEU B 2 129 ? -19.510 27.593 31.886  1.00 18.16 ? 129 LEU H O   1 
ATOM   1677 C CB  . LEU B 2 129 ? -18.922 27.864 29.085  1.00 17.34 ? 129 LEU H CB  1 
ATOM   1678 C CG  . LEU B 2 129 ? -18.531 28.359 27.690  1.00 17.43 ? 129 LEU H CG  1 
ATOM   1679 C CD1 . LEU B 2 129 ? -17.257 27.701 27.181  1.00 19.17 ? 129 LEU H CD1 1 
ATOM   1680 C CD2 . LEU B 2 129 ? -19.667 28.099 26.739  1.00 16.56 ? 129 LEU H CD2 1 
ATOM   1681 N N   . ALA B 2 130 ? -21.682 28.060 31.468  1.00 18.82 ? 130 ALA H N   1 
ATOM   1682 C CA  . ALA B 2 130 ? -21.945 27.803 32.880  1.00 25.02 ? 130 ALA H CA  1 
ATOM   1683 C C   . ALA B 2 130 ? -22.376 26.359 33.125  1.00 27.32 ? 130 ALA H C   1 
ATOM   1684 O O   . ALA B 2 130 ? -23.067 25.764 32.293  1.00 29.54 ? 130 ALA H O   1 
ATOM   1685 C CB  . ALA B 2 130 ? -23.025 28.751 33.407  1.00 23.97 ? 130 ALA H CB  1 
ATOM   1686 N N   . PRO B 2 131 ? -21.979 25.779 34.274  1.00 29.43 ? 131 PRO H N   1 
ATOM   1687 C CA  . PRO B 2 131 ? -22.264 24.382 34.636  1.00 31.57 ? 131 PRO H CA  1 
ATOM   1688 C C   . PRO B 2 131 ? -23.692 24.146 35.129  1.00 35.33 ? 131 PRO H C   1 
ATOM   1689 O O   . PRO B 2 131 ? -24.459 25.108 35.232  1.00 38.20 ? 131 PRO H O   1 
ATOM   1690 C CB  . PRO B 2 131 ? -21.250 24.102 35.755  1.00 30.15 ? 131 PRO H CB  1 
ATOM   1691 C CG  . PRO B 2 131 ? -20.993 25.426 36.376  1.00 29.29 ? 131 PRO H CG  1 
ATOM   1692 C CD  . PRO B 2 131 ? -21.110 26.443 35.267  1.00 29.71 ? 131 PRO H CD  1 
ATOM   1693 N N   . SER B 2 137 ? -22.743 16.468 36.095  1.00 49.71 ? 137 SER H N   1 
ATOM   1694 C CA  . SER B 2 137 ? -23.731 15.410 36.276  1.00 49.84 ? 137 SER H CA  1 
ATOM   1695 C C   . SER B 2 137 ? -23.132 14.186 36.969  1.00 50.76 ? 137 SER H C   1 
ATOM   1696 O O   . SER B 2 137 ? -23.858 13.274 37.376  1.00 51.50 ? 137 SER H O   1 
ATOM   1697 C CB  . SER B 2 137 ? -24.335 15.006 34.930  1.00 48.11 ? 137 SER H CB  1 
ATOM   1698 O OG  . SER B 2 137 ? -25.374 15.897 34.560  1.00 55.29 ? 137 SER H OG  1 
ATOM   1699 N N   . GLY B 2 138 ? -21.807 14.171 37.090  1.00 49.00 ? 138 GLY H N   1 
ATOM   1700 C CA  . GLY B 2 138 ? -21.128 13.170 37.890  1.00 44.50 ? 138 GLY H CA  1 
ATOM   1701 C C   . GLY B 2 138 ? -20.447 13.805 39.085  1.00 42.56 ? 138 GLY H C   1 
ATOM   1702 O O   . GLY B 2 138 ? -21.007 14.704 39.724  1.00 43.14 ? 138 GLY H O   1 
ATOM   1703 N N   . GLY B 2 139 ? -19.240 13.347 39.401  1.00 39.74 ? 139 GLY H N   1 
ATOM   1704 C CA  . GLY B 2 139 ? -18.446 14.017 40.408  1.00 36.63 ? 139 GLY H CA  1 
ATOM   1705 C C   . GLY B 2 139 ? -17.649 15.188 39.898  1.00 34.76 ? 139 GLY H C   1 
ATOM   1706 O O   . GLY B 2 139 ? -17.077 15.939 40.695  1.00 37.85 ? 139 GLY H O   1 
ATOM   1707 N N   . THR B 2 140 ? -17.600 15.370 38.581  1.00 34.16 ? 140 THR H N   1 
ATOM   1708 C CA  . THR B 2 140 ? -16.844 16.450 37.963  1.00 32.00 ? 140 THR H CA  1 
ATOM   1709 C C   . THR B 2 140 ? -17.791 17.399 37.242  1.00 28.15 ? 140 THR H C   1 
ATOM   1710 O O   . THR B 2 140 ? -18.729 16.968 36.564  1.00 24.04 ? 140 THR H O   1 
ATOM   1711 C CB  . THR B 2 140 ? -15.797 15.913 36.975  1.00 32.64 ? 140 THR H CB  1 
ATOM   1712 O OG1 . THR B 2 140 ? -16.455 15.411 35.807  1.00 36.77 ? 140 THR H OG1 1 
ATOM   1713 C CG2 . THR B 2 140 ? -15.001 14.793 37.606  1.00 30.62 ? 140 THR H CG2 1 
ATOM   1714 N N   . ALA B 2 141 ? -17.547 18.693 37.403  1.00 24.58 ? 141 ALA H N   1 
ATOM   1715 C CA  . ALA B 2 141 ? -18.314 19.727 36.732  1.00 24.63 ? 141 ALA H CA  1 
ATOM   1716 C C   . ALA B 2 141 ? -17.393 20.468 35.780  1.00 20.89 ? 141 ALA H C   1 
ATOM   1717 O O   . ALA B 2 141 ? -16.179 20.505 35.985  1.00 19.53 ? 141 ALA H O   1 
ATOM   1718 C CB  . ALA B 2 141 ? -18.920 20.709 37.736  1.00 26.47 ? 141 ALA H CB  1 
ATOM   1719 N N   . ALA B 2 142 ? -17.976 21.068 34.748  1.00 17.79 ? 142 ALA H N   1 
ATOM   1720 C CA  . ALA B 2 142 ? -17.208 21.814 33.764  1.00 15.88 ? 142 ALA H CA  1 
ATOM   1721 C C   . ALA B 2 142 ? -17.776 23.214 33.627  1.00 18.19 ? 142 ALA H C   1 
ATOM   1722 O O   . ALA B 2 142 ? -18.996 23.405 33.648  1.00 20.10 ? 142 ALA H O   1 
ATOM   1723 C CB  . ALA B 2 142 ? -17.213 21.109 32.403  1.00 16.89 ? 142 ALA H CB  1 
ATOM   1724 N N   . LEU B 2 143 ? -16.880 24.193 33.523  1.00 17.03 ? 143 LEU H N   1 
ATOM   1725 C CA  . LEU B 2 143 ? -17.293 25.553 33.229  1.00 19.56 ? 143 LEU H CA  1 
ATOM   1726 C C   . LEU B 2 143 ? -16.229 26.175 32.352  1.00 16.26 ? 143 LEU H C   1 
ATOM   1727 O O   . LEU B 2 143 ? -15.174 25.586 32.123  1.00 14.96 ? 143 LEU H O   1 
ATOM   1728 C CB  . LEU B 2 143 ? -17.506 26.375 34.494  1.00 20.13 ? 143 LEU H CB  1 
ATOM   1729 C CG  . LEU B 2 143 ? -16.446 26.176 35.558  1.00 23.63 ? 143 LEU H CG  1 
ATOM   1730 C CD1 . LEU B 2 143 ? -15.701 27.460 35.772  1.00 26.24 ? 143 LEU H CD1 1 
ATOM   1731 C CD2 . LEU B 2 143 ? -17.110 25.733 36.828  1.00 25.07 ? 143 LEU H CD2 1 
ATOM   1732 N N   . GLY B 2 144 ? -16.505 27.379 31.872  1.00 13.86 ? 144 GLY H N   1 
ATOM   1733 C CA  . GLY B 2 144 ? -15.532 28.028 31.020  1.00 16.40 ? 144 GLY H CA  1 
ATOM   1734 C C   . GLY B 2 144 ? -15.982 29.397 30.561  1.00 16.01 ? 144 GLY H C   1 
ATOM   1735 O O   . GLY B 2 144 ? -16.973 29.954 31.037  1.00 14.37 ? 144 GLY H O   1 
ATOM   1736 N N   . CYS B 2 145 ? -15.204 29.932 29.620  1.00 17.23 ? 145 CYS H N   1 
ATOM   1737 C CA  . CYS B 2 145 ? -15.456 31.222 28.997  1.00 14.44 ? 145 CYS H CA  1 
ATOM   1738 C C   . CYS B 2 145 ? -15.331 31.075 27.494  1.00 19.09 ? 145 CYS H C   1 
ATOM   1739 O O   . CYS B 2 145 ? -14.368 30.465 26.997  1.00 14.00 ? 145 CYS H O   1 
ATOM   1740 C CB  . CYS B 2 145 ? -14.471 32.272 29.487  1.00 18.95 ? 145 CYS H CB  1 
ATOM   1741 S SG  . CYS B 2 145 ? -14.823 32.850 31.146  1.00 21.10 ? 145 CYS H SG  1 
ATOM   1742 N N   . LEU B 2 146 ? -16.299 31.640 26.779  1.00 17.72 ? 146 LEU H N   1 
ATOM   1743 C CA  . LEU B 2 146 ? -16.249 31.750 25.328  1.00 15.31 ? 146 LEU H CA  1 
ATOM   1744 C C   . LEU B 2 146 ? -15.711 33.133 24.970  1.00 16.16 ? 146 LEU H C   1 
ATOM   1745 O O   . LEU B 2 146 ? -16.273 34.147 25.389  1.00 14.16 ? 146 LEU H O   1 
ATOM   1746 C CB  . LEU B 2 146 ? -17.639 31.519 24.738  1.00 14.65 ? 146 LEU H CB  1 
ATOM   1747 C CG  . LEU B 2 146 ? -17.836 31.767 23.244  1.00 15.07 ? 146 LEU H CG  1 
ATOM   1748 C CD1 . LEU B 2 146 ? -16.999 30.795 22.436  1.00 17.06 ? 146 LEU H CD1 1 
ATOM   1749 C CD2 . LEU B 2 146 ? -19.297 31.639 22.869  1.00 16.76 ? 146 LEU H CD2 1 
ATOM   1750 N N   . VAL B 2 147 ? -14.616 33.176 24.224  1.00 15.47 ? 147 VAL H N   1 
ATOM   1751 C CA  . VAL B 2 147 ? -13.955 34.427 23.881  1.00 16.27 ? 147 VAL H CA  1 
ATOM   1752 C C   . VAL B 2 147 ? -14.235 34.661 22.402  1.00 17.07 ? 147 VAL H C   1 
ATOM   1753 O O   . VAL B 2 147 ? -13.600 34.042 21.540  1.00 15.62 ? 147 VAL H O   1 
ATOM   1754 C CB  . VAL B 2 147 ? -12.455 34.373 24.195  1.00 17.37 ? 147 VAL H CB  1 
ATOM   1755 C CG1 . VAL B 2 147 ? -11.805 35.711 23.914  1.00 17.49 ? 147 VAL H CG1 1 
ATOM   1756 C CG2 . VAL B 2 147 ? -12.248 34.016 25.653  1.00 15.55 ? 147 VAL H CG2 1 
ATOM   1757 N N   . LYS B 2 148 ? -15.209 35.520 22.091  1.00 15.62 ? 148 LYS H N   1 
ATOM   1758 C CA  . LYS B 2 148 ? -15.782 35.565 20.751  1.00 14.28 ? 148 LYS H CA  1 
ATOM   1759 C C   . LYS B 2 148 ? -15.471 36.868 20.026  1.00 13.49 ? 148 LYS H C   1 
ATOM   1760 O O   . LYS B 2 148 ? -15.522 37.949 20.621  1.00 13.60 ? 148 LYS H O   1 
ATOM   1761 C CB  . LYS B 2 148 ? -17.298 35.376 20.789  1.00 14.48 ? 148 LYS H CB  1 
ATOM   1762 C CG  . LYS B 2 148 ? -17.816 34.767 19.504  1.00 18.55 ? 148 LYS H CG  1 
ATOM   1763 C CD  . LYS B 2 148 ? -19.266 34.369 19.593  1.00 18.76 ? 148 LYS H CD  1 
ATOM   1764 C CE  . LYS B 2 148 ? -19.954 34.533 18.265  1.00 21.01 ? 148 LYS H CE  1 
ATOM   1765 N NZ  . LYS B 2 148 ? -19.303 33.710 17.227  1.00 25.91 ? 148 LYS H NZ  1 
ATOM   1766 N N   . ASP B 2 149 ? -15.154 36.744 18.729  1.00 14.73 ? 149 ASP H N   1 
ATOM   1767 C CA  . ASP B 2 149 ? -15.163 37.829 17.745  1.00 14.66 ? 149 ASP H CA  1 
ATOM   1768 C C   . ASP B 2 149 ? -14.045 38.838 17.968  1.00 14.56 ? 149 ASP H C   1 
ATOM   1769 O O   . ASP B 2 149 ? -14.297 40.009 18.272  1.00 13.72 ? 149 ASP H O   1 
ATOM   1770 C CB  . ASP B 2 149 ? -16.524 38.538 17.740  1.00 17.35 ? 149 ASP H CB  1 
ATOM   1771 C CG  . ASP B 2 149 ? -17.637 37.662 17.205  1.00 17.93 ? 149 ASP H CG  1 
ATOM   1772 O OD1 . ASP B 2 149 ? -17.352 36.687 16.467  1.00 16.80 ? 149 ASP H OD1 1 
ATOM   1773 O OD2 . ASP B 2 149 ? -18.821 37.941 17.521  1.00 18.18 ? 149 ASP H OD2 1 
ATOM   1774 N N   . TYR B 2 150 ? -12.799 38.400 17.793  1.00 15.47 ? 150 TYR H N   1 
ATOM   1775 C CA  . TYR B 2 150 ? -11.650 39.264 17.999  1.00 13.66 ? 150 TYR H CA  1 
ATOM   1776 C C   . TYR B 2 150 ? -10.683 39.124 16.832  1.00 12.60 ? 150 TYR H C   1 
ATOM   1777 O O   . TYR B 2 150 ? -10.674 38.118 16.109  1.00 12.41 ? 150 TYR H O   1 
ATOM   1778 C CB  . TYR B 2 150 ? -10.938 38.962 19.332  1.00 15.26 ? 150 TYR H CB  1 
ATOM   1779 C CG  . TYR B 2 150 ? -10.295 37.596 19.404  1.00 17.09 ? 150 TYR H CG  1 
ATOM   1780 C CD1 . TYR B 2 150 ? -8.997  37.394 18.945  1.00 15.34 ? 150 TYR H CD1 1 
ATOM   1781 C CD2 . TYR B 2 150 ? -10.962 36.517 19.980  1.00 13.26 ? 150 TYR H CD2 1 
ATOM   1782 C CE1 . TYR B 2 150 ? -8.411  36.155 19.009  1.00 15.78 ? 150 TYR H CE1 1 
ATOM   1783 C CE2 . TYR B 2 150 ? -10.387 35.275 20.045  1.00 14.45 ? 150 TYR H CE2 1 
ATOM   1784 C CZ  . TYR B 2 150 ? -9.092  35.105 19.570  1.00 17.04 ? 150 TYR H CZ  1 
ATOM   1785 O OH  . TYR B 2 150 ? -8.501  33.862 19.635  1.00 16.85 ? 150 TYR H OH  1 
ATOM   1786 N N   . PHE B 2 151 ? -9.870  40.170 16.659  1.00 13.93 ? 151 PHE H N   1 
ATOM   1787 C CA  . PHE B 2 151 ? -8.839  40.191 15.633  1.00 13.37 ? 151 PHE H CA  1 
ATOM   1788 C C   . PHE B 2 151 ? -7.836  41.256 16.028  1.00 14.06 ? 151 PHE H C   1 
ATOM   1789 O O   . PHE B 2 151 ? -8.249  42.323 16.497  1.00 14.32 ? 151 PHE H O   1 
ATOM   1790 C CB  . PHE B 2 151 ? -9.419  40.505 14.247  1.00 15.62 ? 151 PHE H CB  1 
ATOM   1791 C CG  . PHE B 2 151 ? -8.404  40.434 13.141  1.00 14.69 ? 151 PHE H CG  1 
ATOM   1792 C CD1 . PHE B 2 151 ? -7.612  41.536 12.830  1.00 17.06 ? 151 PHE H CD1 1 
ATOM   1793 C CD2 . PHE B 2 151 ? -8.238  39.261 12.426  1.00 14.32 ? 151 PHE H CD2 1 
ATOM   1794 C CE1 . PHE B 2 151 ? -6.652  41.466 11.822  1.00 17.05 ? 151 PHE H CE1 1 
ATOM   1795 C CE2 . PHE B 2 151 ? -7.290  39.180 11.402  1.00 16.71 ? 151 PHE H CE2 1 
ATOM   1796 C CZ  . PHE B 2 151 ? -6.498  40.284 11.102  1.00 14.71 ? 151 PHE H CZ  1 
ATOM   1797 N N   . PRO B 2 152 ? -6.530  41.015 15.844  1.00 17.20 ? 152 PRO H N   1 
ATOM   1798 C CA  . PRO B 2 152 ? -5.912  39.791 15.350  1.00 15.15 ? 152 PRO H CA  1 
ATOM   1799 C C   . PRO B 2 152 ? -5.698  38.835 16.496  1.00 15.62 ? 152 PRO H C   1 
ATOM   1800 O O   . PRO B 2 152 ? -6.079  39.146 17.618  1.00 17.60 ? 152 PRO H O   1 
ATOM   1801 C CB  . PRO B 2 152 ? -4.588  40.296 14.766  1.00 17.18 ? 152 PRO H CB  1 
ATOM   1802 C CG  . PRO B 2 152 ? -4.206  41.389 15.705  1.00 17.71 ? 152 PRO H CG  1 
ATOM   1803 C CD  . PRO B 2 152 ? -5.521  42.051 16.107  1.00 17.93 ? 152 PRO H CD  1 
ATOM   1804 N N   . GLU B 2 153 ? -5.123  37.662 16.246  1.00 17.51 ? 153 GLU H N   1 
ATOM   1805 C CA  . GLU B 2 153 ? -4.623  36.838 17.329  1.00 16.65 ? 153 GLU H CA  1 
ATOM   1806 C C   . GLU B 2 153 ? -3.442  37.537 17.990  1.00 20.86 ? 153 GLU H C   1 
ATOM   1807 O O   . GLU B 2 153 ? -2.810  38.401 17.384  1.00 19.42 ? 153 GLU H O   1 
ATOM   1808 C CB  . GLU B 2 153 ? -4.195  35.480 16.807  1.00 17.73 ? 153 GLU H CB  1 
ATOM   1809 C CG  . GLU B 2 153 ? -5.297  34.689 16.163  1.00 19.43 ? 153 GLU H CG  1 
ATOM   1810 C CD  . GLU B 2 153 ? -4.925  33.240 16.070  1.00 22.54 ? 153 GLU H CD  1 
ATOM   1811 O OE1 . GLU B 2 153 ? -5.124  32.532 17.078  1.00 22.73 ? 153 GLU H OE1 1 
ATOM   1812 O OE2 . GLU B 2 153 ? -4.389  32.818 15.022  1.00 22.70 ? 153 GLU H OE2 1 
ATOM   1813 N N   . PRO B 2 154 ? -3.117  37.181 19.234  1.00 20.13 ? 154 PRO H N   1 
ATOM   1814 C CA  . PRO B 2 154 ? -3.743  36.189 20.103  1.00 19.15 ? 154 PRO H CA  1 
ATOM   1815 C C   . PRO B 2 154 ? -4.542  36.798 21.239  1.00 21.03 ? 154 PRO H C   1 
ATOM   1816 O O   . PRO B 2 154 ? -4.451  37.992 21.511  1.00 17.25 ? 154 PRO H O   1 
ATOM   1817 C CB  . PRO B 2 154 ? -2.529  35.447 20.661  1.00 19.59 ? 154 PRO H CB  1 
ATOM   1818 C CG  . PRO B 2 154 ? -1.559  36.585 20.909  1.00 21.59 ? 154 PRO H CG  1 
ATOM   1819 C CD  . PRO B 2 154 ? -1.821  37.601 19.800  1.00 21.76 ? 154 PRO H CD  1 
ATOM   1820 N N   . VAL B 2 155 ? -5.321  35.957 21.919  1.00 19.50 ? 155 VAL H N   1 
ATOM   1821 C CA  . VAL B 2 155 ? -5.838  36.244 23.251  1.00 19.50 ? 155 VAL H CA  1 
ATOM   1822 C C   . VAL B 2 155 ? -5.142  35.304 24.219  1.00 21.61 ? 155 VAL H C   1 
ATOM   1823 O O   . VAL B 2 155 ? -4.834  34.157 23.881  1.00 22.94 ? 155 VAL H O   1 
ATOM   1824 C CB  . VAL B 2 155 ? -7.367  36.060 23.377  1.00 20.57 ? 155 VAL H CB  1 
ATOM   1825 C CG1 . VAL B 2 155 ? -8.127  37.030 22.496  1.00 17.57 ? 155 VAL H CG1 1 
ATOM   1826 C CG2 . VAL B 2 155 ? -7.748  34.638 23.059  1.00 18.90 ? 155 VAL H CG2 1 
ATOM   1827 N N   . THR B 2 156 ? -4.901  35.792 25.428  1.00 20.99 ? 156 THR H N   1 
ATOM   1828 C CA  . THR B 2 156 ? -4.474  34.965 26.550  1.00 22.95 ? 156 THR H CA  1 
ATOM   1829 C C   . THR B 2 156 ? -5.641  34.771 27.515  1.00 21.07 ? 156 THR H C   1 
ATOM   1830 O O   . THR B 2 156 ? -6.521  35.629 27.635  1.00 18.35 ? 156 THR H O   1 
ATOM   1831 C CB  . THR B 2 156 ? -3.300  35.605 27.289  1.00 21.41 ? 156 THR H CB  1 
ATOM   1832 O OG1 . THR B 2 156 ? -3.697  36.887 27.789  1.00 22.62 ? 156 THR H OG1 1 
ATOM   1833 C CG2 . THR B 2 156 ? -2.117  35.776 26.355  1.00 24.11 ? 156 THR H CG2 1 
ATOM   1834 N N   . VAL B 2 157 ? -5.662  33.619 28.185  1.00 16.72 ? 157 VAL H N   1 
ATOM   1835 C CA  . VAL B 2 157 ? -6.705  33.303 29.157  1.00 13.87 ? 157 VAL H CA  1 
ATOM   1836 C C   . VAL B 2 157 ? -6.054  32.643 30.358  1.00 17.39 ? 157 VAL H C   1 
ATOM   1837 O O   . VAL B 2 157 ? -5.330  31.656 30.214  1.00 16.67 ? 157 VAL H O   1 
ATOM   1838 C CB  . VAL B 2 157 ? -7.797  32.370 28.602  1.00 17.28 ? 157 VAL H CB  1 
ATOM   1839 C CG1 . VAL B 2 157 ? -8.863  32.149 29.654  1.00 16.29 ? 157 VAL H CG1 1 
ATOM   1840 C CG2 . VAL B 2 157 ? -8.417  32.937 27.311  1.00 17.33 ? 157 VAL H CG2 1 
ATOM   1841 N N   . SER B 2 158 ? -6.315  33.172 31.538  1.00 17.08 ? 158 SER H N   1 
ATOM   1842 C CA  . SER B 2 158 ? -5.977  32.493 32.777  1.00 16.27 ? 158 SER H CA  1 
ATOM   1843 C C   . SER B 2 158 ? -7.240  32.347 33.614  1.00 17.90 ? 158 SER H C   1 
ATOM   1844 O O   . SER B 2 158 ? -8.312  32.844 33.259  1.00 15.47 ? 158 SER H O   1 
ATOM   1845 C CB  . SER B 2 158 ? -4.894  33.252 33.551  1.00 17.02 ? 158 SER H CB  1 
ATOM   1846 O OG  . SER B 2 158 ? -5.353  34.531 33.951  1.00 17.37 ? 158 SER H OG  1 
ATOM   1847 N N   . TRP B 2 159 ? -7.112  31.631 34.724  1.00 21.98 ? 159 TRP H N   1 
ATOM   1848 C CA  . TRP B 2 159 ? -8.225  31.429 35.637  1.00 17.71 ? 159 TRP H CA  1 
ATOM   1849 C C   . TRP B 2 159 ? -7.779  31.808 37.036  1.00 19.81 ? 159 TRP H C   1 
ATOM   1850 O O   . TRP B 2 159 ? -6.685  31.425 37.471  1.00 18.77 ? 159 TRP H O   1 
ATOM   1851 C CB  . TRP B 2 159 ? -8.721  29.985 35.607  1.00 17.63 ? 159 TRP H CB  1 
ATOM   1852 C CG  . TRP B 2 159 ? -9.495  29.671 34.386  1.00 14.67 ? 159 TRP H CG  1 
ATOM   1853 C CD1 . TRP B 2 159 ? -8.998  29.233 33.199  1.00 13.63 ? 159 TRP H CD1 1 
ATOM   1854 C CD2 . TRP B 2 159 ? -10.915 29.784 34.214  1.00 15.02 ? 159 TRP H CD2 1 
ATOM   1855 N NE1 . TRP B 2 159 ? -10.018 29.047 32.302  1.00 12.84 ? 159 TRP H NE1 1 
ATOM   1856 C CE2 . TRP B 2 159 ? -11.205 29.389 32.896  1.00 14.29 ? 159 TRP H CE2 1 
ATOM   1857 C CE3 . TRP B 2 159 ? -11.967 30.178 35.049  1.00 16.14 ? 159 TRP H CE3 1 
ATOM   1858 C CZ2 . TRP B 2 159 ? -12.512 29.367 32.388  1.00 16.81 ? 159 TRP H CZ2 1 
ATOM   1859 C CZ3 . TRP B 2 159 ? -13.262 30.161 34.547  1.00 15.42 ? 159 TRP H CZ3 1 
ATOM   1860 C CH2 . TRP B 2 159 ? -13.524 29.760 33.229  1.00 17.08 ? 159 TRP H CH2 1 
ATOM   1861 N N   . ASN B 2 160 ? -8.627  32.561 37.729  1.00 17.59 ? 160 ASN H N   1 
ATOM   1862 C CA  . ASN B 2 160 ? -8.326  33.049 39.066  1.00 17.78 ? 160 ASN H CA  1 
ATOM   1863 C C   . ASN B 2 160 ? -6.906  33.609 39.136  1.00 15.99 ? 160 ASN H C   1 
ATOM   1864 O O   . ASN B 2 160 ? -6.136  33.316 40.050  1.00 18.00 ? 160 ASN H O   1 
ATOM   1865 C CB  . ASN B 2 160 ? -8.574  31.940 40.092  1.00 18.41 ? 160 ASN H CB  1 
ATOM   1866 C CG  . ASN B 2 160 ? -10.028 31.483 40.092  1.00 22.28 ? 160 ASN H CG  1 
ATOM   1867 O OD1 . ASN B 2 160 ? -10.891 32.167 39.550  1.00 22.79 ? 160 ASN H OD1 1 
ATOM   1868 N ND2 . ASN B 2 160 ? -10.304 30.339 40.699  1.00 21.90 ? 160 ASN H ND2 1 
ATOM   1869 N N   . SER B 2 161 ? -6.566  34.431 38.135  1.00 14.26 ? 161 SER H N   1 
ATOM   1870 C CA  . SER B 2 161 ? -5.292  35.148 38.035  1.00 16.20 ? 161 SER H CA  1 
ATOM   1871 C C   . SER B 2 161 ? -4.087  34.226 37.931  1.00 17.22 ? 161 SER H C   1 
ATOM   1872 O O   . SER B 2 161 ? -2.956  34.667 38.159  1.00 15.95 ? 161 SER H O   1 
ATOM   1873 C CB  . SER B 2 161 ? -5.089  36.113 39.211  1.00 19.11 ? 161 SER H CB  1 
ATOM   1874 O OG  . SER B 2 161 ? -6.199  36.973 39.330  1.00 20.46 ? 161 SER H OG  1 
ATOM   1875 N N   . GLY B 2 162 ? -4.287  32.963 37.559  1.00 16.29 ? 162 GLY H N   1 
ATOM   1876 C CA  . GLY B 2 162 ? -3.209  32.008 37.491  1.00 15.90 ? 162 GLY H CA  1 
ATOM   1877 C C   . GLY B 2 162 ? -3.205  31.001 38.620  1.00 18.67 ? 162 GLY H C   1 
ATOM   1878 O O   . GLY B 2 162 ? -2.431  30.035 38.566  1.00 17.37 ? 162 GLY H O   1 
ATOM   1879 N N   . ALA B 2 163 ? -4.054  31.192 39.634  1.00 14.71 ? 163 ALA H N   1 
ATOM   1880 C CA  . ALA B 2 163 ? -4.086  30.284 40.769  1.00 19.41 ? 163 ALA H CA  1 
ATOM   1881 C C   . ALA B 2 163 ? -4.841  28.999 40.463  1.00 19.66 ? 163 ALA H C   1 
ATOM   1882 O O   . ALA B 2 163 ? -4.697  28.022 41.207  1.00 19.84 ? 163 ALA H O   1 
ATOM   1883 C CB  . ALA B 2 163 ? -4.706  30.974 41.990  1.00 18.01 ? 163 ALA H CB  1 
ATOM   1884 N N   . LEU B 2 164 ? -5.630  28.974 39.387  1.00 19.05 ? 164 LEU H N   1 
ATOM   1885 C CA  . LEU B 2 164 ? -6.336  27.775 38.944  1.00 17.93 ? 164 LEU H CA  1 
ATOM   1886 C C   . LEU B 2 164 ? -5.733  27.363 37.606  1.00 19.53 ? 164 LEU H C   1 
ATOM   1887 O O   . LEU B 2 164 ? -6.011  27.967 36.568  1.00 20.31 ? 164 LEU H O   1 
ATOM   1888 C CB  . LEU B 2 164 ? -7.838  28.011 38.842  1.00 15.70 ? 164 LEU H CB  1 
ATOM   1889 C CG  . LEU B 2 164 ? -8.720  26.891 38.283  1.00 20.43 ? 164 LEU H CG  1 
ATOM   1890 C CD1 . LEU B 2 164 ? -8.413  25.543 38.903  1.00 21.03 ? 164 LEU H CD1 1 
ATOM   1891 C CD2 . LEU B 2 164 ? -10.163 27.255 38.526  1.00 21.30 ? 164 LEU H CD2 1 
ATOM   1892 N N   . THR B 2 165 ? -4.852  26.366 37.677  1.00 19.28 ? 165 THR H N   1 
ATOM   1893 C CA  . THR B 2 165 ? -4.281  25.663 36.535  1.00 19.47 ? 165 THR H CA  1 
ATOM   1894 C C   . THR B 2 165 ? -4.227  24.216 36.973  1.00 29.89 ? 165 THR H C   1 
ATOM   1895 O O   . THR B 2 165 ? -3.395  23.858 37.814  1.00 33.53 ? 165 THR H O   1 
ATOM   1896 C CB  . THR B 2 165 ? -2.861  26.082 36.217  1.00 22.40 ? 165 THR H CB  1 
ATOM   1897 O OG1 . THR B 2 165 ? -2.031  25.429 37.180  1.00 23.54 ? 165 THR H OG1 1 
ATOM   1898 C CG2 . THR B 2 165 ? -2.669  27.561 36.315  1.00 20.14 ? 165 THR H CG2 1 
ATOM   1899 N N   . SER B 2 166 ? -5.048  23.402 36.370  1.00 24.14 ? 166 SER H N   1 
ATOM   1900 C CA  . SER B 2 166 ? -5.260  22.018 36.748  1.00 23.75 ? 166 SER H CA  1 
ATOM   1901 C C   . SER B 2 166 ? -6.623  21.768 36.164  1.00 21.29 ? 166 SER H C   1 
ATOM   1902 O O   . SER B 2 166 ? -7.602  22.385 36.602  1.00 23.59 ? 166 SER H O   1 
ATOM   1903 C CB  . SER B 2 166 ? -5.250  21.771 38.260  1.00 27.58 ? 166 SER H CB  1 
ATOM   1904 O OG  . SER B 2 166 ? -5.413  20.392 38.539  1.00 31.49 ? 166 SER H OG  1 
ATOM   1905 N N   . GLY B 2 167 ? -6.674  20.961 35.119  1.00 22.05 ? 167 GLY H N   1 
ATOM   1906 C CA  . GLY B 2 167 ? -7.913  20.734 34.421  1.00 21.50 ? 167 GLY H CA  1 
ATOM   1907 C C   . GLY B 2 167 ? -8.328  21.837 33.471  1.00 20.58 ? 167 GLY H C   1 
ATOM   1908 O O   . GLY B 2 167 ? -9.408  21.730 32.871  1.00 18.09 ? 167 GLY H O   1 
ATOM   1909 N N   . VAL B 2 168 ? -7.530  22.893 33.331  1.00 17.77 ? 168 VAL H N   1 
ATOM   1910 C CA  . VAL B 2 168 ? -7.818  23.951 32.365  1.00 16.67 ? 168 VAL H CA  1 
ATOM   1911 C C   . VAL B 2 168 ? -7.419  23.483 30.973  1.00 16.59 ? 168 VAL H C   1 
ATOM   1912 O O   . VAL B 2 168 ? -6.320  22.943 30.772  1.00 14.90 ? 168 VAL H O   1 
ATOM   1913 C CB  . VAL B 2 168 ? -7.084  25.247 32.735  1.00 17.03 ? 168 VAL H CB  1 
ATOM   1914 C CG1 . VAL B 2 168 ? -7.199  26.257 31.609  1.00 18.03 ? 168 VAL H CG1 1 
ATOM   1915 C CG2 . VAL B 2 168 ? -7.639  25.825 34.020  1.00 16.75 ? 168 VAL H CG2 1 
ATOM   1916 N N   . HIS B 2 169 ? -8.302  23.707 30.005  1.00 14.64 ? 169 HIS H N   1 
ATOM   1917 C CA  . HIS B 2 169 ? -8.021  23.484 28.587  1.00 16.67 ? 169 HIS H CA  1 
ATOM   1918 C C   . HIS B 2 169 ? -8.423  24.735 27.822  1.00 14.74 ? 169 HIS H C   1 
ATOM   1919 O O   . HIS B 2 169 ? -9.614  25.035 27.715  1.00 16.16 ? 169 HIS H O   1 
ATOM   1920 C CB  . HIS B 2 169 ? -8.785  22.281 28.048  1.00 15.80 ? 169 HIS H CB  1 
ATOM   1921 C CG  . HIS B 2 169 ? -8.271  20.967 28.533  1.00 17.22 ? 169 HIS H CG  1 
ATOM   1922 N ND1 . HIS B 2 169 ? -6.943  20.613 28.445  1.00 17.51 ? 169 HIS H ND1 1 
ATOM   1923 C CD2 . HIS B 2 169 ? -8.909  19.908 29.081  1.00 19.36 ? 169 HIS H CD2 1 
ATOM   1924 C CE1 . HIS B 2 169 ? -6.782  19.399 28.938  1.00 17.33 ? 169 HIS H CE1 1 
ATOM   1925 N NE2 . HIS B 2 169 ? -7.957  18.953 29.340  1.00 16.57 ? 169 HIS H NE2 1 
ATOM   1926 N N   . THR B 2 170 ? -7.449  25.441 27.261  1.00 13.64 ? 170 THR H N   1 
ATOM   1927 C CA  . THR B 2 170 ? -7.715  26.603 26.418  1.00 16.31 ? 170 THR H CA  1 
ATOM   1928 C C   . THR B 2 170 ? -7.516  26.165 24.977  1.00 16.38 ? 170 THR H C   1 
ATOM   1929 O O   . THR B 2 170 ? -6.399  25.819 24.570  1.00 15.47 ? 170 THR H O   1 
ATOM   1930 C CB  . THR B 2 170 ? -6.814  27.780 26.781  1.00 17.74 ? 170 THR H CB  1 
ATOM   1931 O OG1 . THR B 2 170 ? -7.083  28.184 28.134  1.00 16.35 ? 170 THR H OG1 1 
ATOM   1932 C CG2 . THR B 2 170 ? -7.098  28.968 25.845  1.00 14.76 ? 170 THR H CG2 1 
ATOM   1933 N N   . PHE B 2 171 ? -8.605  26.120 24.226  1.00 13.89 ? 171 PHE H N   1 
ATOM   1934 C CA  . PHE B 2 171 ? -8.552  25.540 22.897  1.00 13.56 ? 171 PHE H CA  1 
ATOM   1935 C C   . PHE B 2 171 ? -7.860  26.485 21.922  1.00 15.96 ? 171 PHE H C   1 
ATOM   1936 O O   . PHE B 2 171 ? -7.843  27.701 22.133  1.00 14.66 ? 171 PHE H O   1 
ATOM   1937 C CB  . PHE B 2 171 ? -9.957  25.214 22.400  1.00 14.77 ? 171 PHE H CB  1 
ATOM   1938 C CG  . PHE B 2 171 ? -10.586 24.077 23.136  1.00 15.14 ? 171 PHE H CG  1 
ATOM   1939 C CD1 . PHE B 2 171 ? -10.281 22.771 22.800  1.00 15.11 ? 171 PHE H CD1 1 
ATOM   1940 C CD2 . PHE B 2 171 ? -11.436 24.314 24.205  1.00 16.76 ? 171 PHE H CD2 1 
ATOM   1941 C CE1 . PHE B 2 171 ? -10.838 21.698 23.499  1.00 15.49 ? 171 PHE H CE1 1 
ATOM   1942 C CE2 . PHE B 2 171 ? -12.004 23.256 24.913  1.00 18.55 ? 171 PHE H CE2 1 
ATOM   1943 C CZ  . PHE B 2 171 ? -11.712 21.944 24.554  1.00 16.65 ? 171 PHE H CZ  1 
ATOM   1944 N N   . PRO B 2 172 ? -7.262  25.945 20.859  1.00 14.64 ? 172 PRO H N   1 
ATOM   1945 C CA  . PRO B 2 172 ? -6.789  26.799 19.771  1.00 16.53 ? 172 PRO H CA  1 
ATOM   1946 C C   . PRO B 2 172 ? -7.935  27.650 19.258  1.00 18.01 ? 172 PRO H C   1 
ATOM   1947 O O   . PRO B 2 172 ? -9.088  27.223 19.240  1.00 15.93 ? 172 PRO H O   1 
ATOM   1948 C CB  . PRO B 2 172 ? -6.323  25.805 18.704  1.00 16.82 ? 172 PRO H CB  1 
ATOM   1949 C CG  . PRO B 2 172 ? -6.068  24.518 19.443  1.00 19.18 ? 172 PRO H CG  1 
ATOM   1950 C CD  . PRO B 2 172 ? -7.028  24.515 20.599  1.00 15.59 ? 172 PRO H CD  1 
ATOM   1951 N N   . ALA B 2 173 ? -7.609  28.862 18.834  1.00 17.92 ? 173 ALA H N   1 
ATOM   1952 C CA  . ALA B 2 173 ? -8.620  29.710 18.221  1.00 18.04 ? 173 ALA H CA  1 
ATOM   1953 C C   . ALA B 2 173 ? -9.063  29.149 16.873  1.00 19.98 ? 173 ALA H C   1 
ATOM   1954 O O   . ALA B 2 173 ? -8.306  28.459 16.176  1.00 20.60 ? 173 ALA H O   1 
ATOM   1955 C CB  . ALA B 2 173 ? -8.085  31.133 18.046  1.00 19.13 ? 173 ALA H CB  1 
ATOM   1956 N N   . VAL B 2 174 ? -10.312 29.438 16.509  1.00 16.61 ? 174 VAL H N   1 
ATOM   1957 C CA  . VAL B 2 174 ? -10.841 29.111 15.189  1.00 17.34 ? 174 VAL H CA  1 
ATOM   1958 C C   . VAL B 2 174 ? -11.119 30.403 14.427  1.00 18.05 ? 174 VAL H C   1 
ATOM   1959 O O   . VAL B 2 174 ? -11.575 31.402 14.998  1.00 19.08 ? 174 VAL H O   1 
ATOM   1960 C CB  . VAL B 2 174 ? -12.104 28.227 15.258  1.00 21.67 ? 174 VAL H CB  1 
ATOM   1961 C CG1 . VAL B 2 174 ? -11.795 26.928 15.994  1.00 21.13 ? 174 VAL H CG1 1 
ATOM   1962 C CG2 . VAL B 2 174 ? -13.274 28.957 15.911  1.00 22.04 ? 174 VAL H CG2 1 
ATOM   1963 N N   . LEU B 2 175 ? -10.827 30.387 13.139  1.00 17.73 ? 175 LEU H N   1 
ATOM   1964 C CA  . LEU B 2 175 ? -11.121 31.523 12.282  1.00 17.83 ? 175 LEU H CA  1 
ATOM   1965 C C   . LEU B 2 175 ? -12.533 31.342 11.754  1.00 16.88 ? 175 LEU H C   1 
ATOM   1966 O O   . LEU B 2 175 ? -12.825 30.355 11.065  1.00 17.13 ? 175 LEU H O   1 
ATOM   1967 C CB  . LEU B 2 175 ? -10.109 31.622 11.141  1.00 18.88 ? 175 LEU H CB  1 
ATOM   1968 C CG  . LEU B 2 175 ? -10.373 32.682 10.061  1.00 20.85 ? 175 LEU H CG  1 
ATOM   1969 C CD1 . LEU B 2 175 ? -10.493 34.069 10.666  1.00 15.28 ? 175 LEU H CD1 1 
ATOM   1970 C CD2 . LEU B 2 175 ? -9.270  32.643 8.996   1.00 17.76 ? 175 LEU H CD2 1 
ATOM   1971 N N   . GLN B 2 176 ? -13.411 32.272 12.102  1.00 16.73 ? 176 GLN H N   1 
ATOM   1972 C CA  . GLN B 2 176 ? -14.800 32.172 11.695  1.00 16.74 ? 176 GLN H CA  1 
ATOM   1973 C C   . GLN B 2 176 ? -14.974 32.720 10.283  1.00 18.98 ? 176 GLN H C   1 
ATOM   1974 O O   . GLN B 2 176 ? -14.099 33.394 9.740   1.00 19.26 ? 176 GLN H O   1 
ATOM   1975 C CB  . GLN B 2 176 ? -15.686 32.912 12.688  1.00 18.38 ? 176 GLN H CB  1 
ATOM   1976 C CG  . GLN B 2 176 ? -15.482 32.455 14.121  1.00 15.20 ? 176 GLN H CG  1 
ATOM   1977 C CD  . GLN B 2 176 ? -16.144 33.380 15.122  1.00 19.56 ? 176 GLN H CD  1 
ATOM   1978 O OE1 . GLN B 2 176 ? -17.155 33.027 15.729  1.00 20.41 ? 176 GLN H OE1 1 
ATOM   1979 N NE2 . GLN B 2 176 ? -15.569 34.569 15.310  1.00 16.10 ? 176 GLN H NE2 1 
ATOM   1980 N N   . SER B 2 177 ? -16.123 32.409 9.672   1.00 19.60 ? 177 SER H N   1 
ATOM   1981 C CA  . SER B 2 177 ? -16.415 32.952 8.350   1.00 21.35 ? 177 SER H CA  1 
ATOM   1982 C C   . SER B 2 177 ? -16.485 34.473 8.356   1.00 19.92 ? 177 SER H C   1 
ATOM   1983 O O   . SER B 2 177 ? -16.329 35.086 7.297   1.00 21.46 ? 177 SER H O   1 
ATOM   1984 C CB  . SER B 2 177 ? -17.733 32.392 7.829   1.00 23.25 ? 177 SER H CB  1 
ATOM   1985 O OG  . SER B 2 177 ? -18.754 32.655 8.773   1.00 26.30 ? 177 SER H OG  1 
ATOM   1986 N N   . SER B 2 178 ? -16.709 35.092 9.523   1.00 19.91 ? 178 SER H N   1 
ATOM   1987 C CA  . SER B 2 178 ? -16.712 36.547 9.618   1.00 17.18 ? 178 SER H CA  1 
ATOM   1988 C C   . SER B 2 178 ? -15.325 37.141 9.434   1.00 18.57 ? 178 SER H C   1 
ATOM   1989 O O   . SER B 2 178 ? -15.210 38.352 9.216   1.00 19.41 ? 178 SER H O   1 
ATOM   1990 C CB  . SER B 2 178 ? -17.258 36.985 10.969  1.00 19.10 ? 178 SER H CB  1 
ATOM   1991 O OG  . SER B 2 178 ? -16.375 36.592 12.007  1.00 16.97 ? 178 SER H OG  1 
ATOM   1992 N N   . GLY B 2 179 ? -14.280 36.316 9.490   1.00 17.87 ? 179 GLY H N   1 
ATOM   1993 C CA  . GLY B 2 179 ? -12.922 36.800 9.527   1.00 16.75 ? 179 GLY H CA  1 
ATOM   1994 C C   . GLY B 2 179 ? -12.398 37.113 10.912  1.00 16.87 ? 179 GLY H C   1 
ATOM   1995 O O   . GLY B 2 179 ? -11.218 37.457 11.040  1.00 12.04 ? 179 GLY H O   1 
ATOM   1996 N N   . LEU B 2 180 ? -13.234 37.010 11.947  1.00 13.49 ? 180 LEU H N   1 
ATOM   1997 C CA  . LEU B 2 180 ? -12.800 37.172 13.324  1.00 15.19 ? 180 LEU H CA  1 
ATOM   1998 C C   . LEU B 2 180 ? -12.562 35.814 13.972  1.00 15.13 ? 180 LEU H C   1 
ATOM   1999 O O   . LEU B 2 180 ? -13.136 34.802 13.563  1.00 16.41 ? 180 LEU H O   1 
ATOM   2000 C CB  . LEU B 2 180 ? -13.832 37.949 14.136  1.00 14.92 ? 180 LEU H CB  1 
ATOM   2001 C CG  . LEU B 2 180 ? -14.265 39.283 13.553  1.00 14.30 ? 180 LEU H CG  1 
ATOM   2002 C CD1 . LEU B 2 180 ? -15.350 39.875 14.451  1.00 15.74 ? 180 LEU H CD1 1 
ATOM   2003 C CD2 . LEU B 2 180 ? -13.068 40.180 13.459  1.00 15.37 ? 180 LEU H CD2 1 
ATOM   2004 N N   . TYR B 2 181 ? -11.713 35.812 15.001  1.00 15.24 ? 181 TYR H N   1 
ATOM   2005 C CA  . TYR B 2 181 ? -11.376 34.597 15.725  1.00 14.73 ? 181 TYR H CA  1 
ATOM   2006 C C   . TYR B 2 181 ? -12.306 34.407 16.918  1.00 13.86 ? 181 TYR H C   1 
ATOM   2007 O O   . TYR B 2 181 ? -12.895 35.354 17.428  1.00 14.13 ? 181 TYR H O   1 
ATOM   2008 C CB  . TYR B 2 181 ? -9.926  34.646 16.197  1.00 14.60 ? 181 TYR H CB  1 
ATOM   2009 C CG  . TYR B 2 181 ? -8.936  34.607 15.057  1.00 16.83 ? 181 TYR H CG  1 
ATOM   2010 C CD1 . TYR B 2 181 ? -8.503  33.395 14.531  1.00 19.52 ? 181 TYR H CD1 1 
ATOM   2011 C CD2 . TYR B 2 181 ? -8.457  35.780 14.493  1.00 16.55 ? 181 TYR H CD2 1 
ATOM   2012 C CE1 . TYR B 2 181 ? -7.604  33.353 13.482  1.00 16.96 ? 181 TYR H CE1 1 
ATOM   2013 C CE2 . TYR B 2 181 ? -7.548  35.748 13.444  1.00 16.36 ? 181 TYR H CE2 1 
ATOM   2014 C CZ  . TYR B 2 181 ? -7.136  34.527 12.940  1.00 20.22 ? 181 TYR H CZ  1 
ATOM   2015 O OH  . TYR B 2 181 ? -6.236  34.478 11.890  1.00 21.50 ? 181 TYR H OH  1 
ATOM   2016 N N   . SER B 2 182 ? -12.444 33.152 17.337  1.00 14.35 ? 182 SER H N   1 
ATOM   2017 C CA  . SER B 2 182 ? -13.105 32.786 18.582  1.00 15.04 ? 182 SER H CA  1 
ATOM   2018 C C   . SER B 2 182 ? -12.354 31.623 19.206  1.00 18.45 ? 182 SER H C   1 
ATOM   2019 O O   . SER B 2 182 ? -11.788 30.787 18.497  1.00 18.21 ? 182 SER H O   1 
ATOM   2020 C CB  . SER B 2 182 ? -14.574 32.365 18.363  1.00 18.34 ? 182 SER H CB  1 
ATOM   2021 O OG  . SER B 2 182 ? -15.377 33.476 18.002  1.00 24.85 ? 182 SER H OG  1 
ATOM   2022 N N   . LEU B 2 183 ? -12.342 31.575 20.541  1.00 15.82 ? 183 LEU H N   1 
ATOM   2023 C CA  . LEU B 2 183 ? -11.889 30.375 21.228  1.00 16.48 ? 183 LEU H CA  1 
ATOM   2024 C C   . LEU B 2 183 ? -12.655 30.228 22.527  1.00 17.57 ? 183 LEU H C   1 
ATOM   2025 O O   . LEU B 2 183 ? -13.293 31.172 23.009  1.00 16.92 ? 183 LEU H O   1 
ATOM   2026 C CB  . LEU B 2 183 ? -10.380 30.382 21.512  1.00 17.12 ? 183 LEU H CB  1 
ATOM   2027 C CG  . LEU B 2 183 ? -9.659  31.351 22.450  1.00 19.29 ? 183 LEU H CG  1 
ATOM   2028 C CD1 . LEU B 2 183 ? -9.988  31.181 23.937  1.00 16.49 ? 183 LEU H CD1 1 
ATOM   2029 C CD2 . LEU B 2 183 ? -8.177  31.141 22.233  1.00 18.90 ? 183 LEU H CD2 1 
ATOM   2030 N N   . SER B 2 184 ? -12.562 29.029 23.099  1.00 16.53 ? 184 SER H N   1 
ATOM   2031 C CA  . SER B 2 184 ? -13.079 28.748 24.427  1.00 14.02 ? 184 SER H CA  1 
ATOM   2032 C C   . SER B 2 184 ? -11.952 28.263 25.320  1.00 15.89 ? 184 SER H C   1 
ATOM   2033 O O   . SER B 2 184 ? -10.970 27.684 24.849  1.00 16.07 ? 184 SER H O   1 
ATOM   2034 C CB  . SER B 2 184 ? -14.195 27.711 24.388  1.00 19.55 ? 184 SER H CB  1 
ATOM   2035 O OG  . SER B 2 184 ? -15.349 28.276 23.795  1.00 23.97 ? 184 SER H OG  1 
ATOM   2036 N N   . SER B 2 185 ? -12.089 28.566 26.609  1.00 13.43 ? 185 SER H N   1 
ATOM   2037 C CA  . SER B 2 185 ? -11.259 28.020 27.667  1.00 15.52 ? 185 SER H CA  1 
ATOM   2038 C C   . SER B 2 185 ? -12.194 27.369 28.670  1.00 16.35 ? 185 SER H C   1 
ATOM   2039 O O   . SER B 2 185 ? -13.196 27.973 29.065  1.00 14.41 ? 185 SER H O   1 
ATOM   2040 C CB  . SER B 2 185 ? -10.421 29.111 28.331  1.00 14.87 ? 185 SER H CB  1 
ATOM   2041 O OG  . SER B 2 185 ? -9.636  28.597 29.393  1.00 14.34 ? 185 SER H OG  1 
ATOM   2042 N N   . VAL B 2 186 ? -11.888 26.135 29.058  1.00 13.34 ? 186 VAL H N   1 
ATOM   2043 C CA  . VAL B 2 186 ? -12.733 25.396 29.984  1.00 15.82 ? 186 VAL H CA  1 
ATOM   2044 C C   . VAL B 2 186 ? -11.879 24.880 31.134  1.00 14.53 ? 186 VAL H C   1 
ATOM   2045 O O   . VAL B 2 186 ? -10.646 24.871 31.079  1.00 14.13 ? 186 VAL H O   1 
ATOM   2046 C CB  . VAL B 2 186 ? -13.481 24.233 29.296  1.00 17.97 ? 186 VAL H CB  1 
ATOM   2047 C CG1 . VAL B 2 186 ? -14.351 24.771 28.153  1.00 15.17 ? 186 VAL H CG1 1 
ATOM   2048 C CG2 . VAL B 2 186 ? -12.486 23.198 28.785  1.00 15.96 ? 186 VAL H CG2 1 
ATOM   2049 N N   . VAL B 2 187 ? -12.552 24.484 32.202  1.00 15.14 ? 187 VAL H N   1 
ATOM   2050 C CA  . VAL B 2 187 ? -11.887 23.874 33.345  1.00 17.50 ? 187 VAL H CA  1 
ATOM   2051 C C   . VAL B 2 187 ? -12.869 22.905 33.978  1.00 17.41 ? 187 VAL H C   1 
ATOM   2052 O O   . VAL B 2 187 ? -14.061 23.198 34.083  1.00 15.87 ? 187 VAL H O   1 
ATOM   2053 C CB  . VAL B 2 187 ? -11.401 24.938 34.359  1.00 17.40 ? 187 VAL H CB  1 
ATOM   2054 C CG1 . VAL B 2 187 ? -12.566 25.728 34.957  1.00 16.14 ? 187 VAL H CG1 1 
ATOM   2055 C CG2 . VAL B 2 187 ? -10.583 24.286 35.449  1.00 19.72 ? 187 VAL H CG2 1 
ATOM   2056 N N   . THR B 2 188 ? -12.383 21.734 34.360  1.00 16.92 ? 188 THR H N   1 
ATOM   2057 C CA  . THR B 2 188 ? -13.197 20.799 35.121  1.00 17.04 ? 188 THR H CA  1 
ATOM   2058 C C   . THR B 2 188 ? -12.754 20.830 36.575  1.00 19.88 ? 188 THR H C   1 
ATOM   2059 O O   . THR B 2 188 ? -11.565 20.982 36.877  1.00 19.02 ? 188 THR H O   1 
ATOM   2060 C CB  . THR B 2 188 ? -13.118 19.372 34.567  1.00 18.20 ? 188 THR H CB  1 
ATOM   2061 O OG1 . THR B 2 188 ? -11.757 18.920 34.557  1.00 19.40 ? 188 THR H OG1 1 
ATOM   2062 C CG2 . THR B 2 188 ? -13.674 19.340 33.175  1.00 17.59 ? 188 THR H CG2 1 
ATOM   2063 N N   . VAL B 2 189 ? -13.730 20.715 37.470  1.00 20.58 ? 189 VAL H N   1 
ATOM   2064 C CA  . VAL B 2 189 ? -13.512 20.816 38.908  1.00 27.88 ? 189 VAL H CA  1 
ATOM   2065 C C   . VAL B 2 189 ? -14.392 19.787 39.597  1.00 30.47 ? 189 VAL H C   1 
ATOM   2066 O O   . VAL B 2 189 ? -15.354 19.275 39.008  1.00 23.83 ? 189 VAL H O   1 
ATOM   2067 C CB  . VAL B 2 189 ? -13.834 22.230 39.436  1.00 29.31 ? 189 VAL H CB  1 
ATOM   2068 C CG1 . VAL B 2 189 ? -12.778 23.223 38.978  1.00 27.80 ? 189 VAL H CG1 1 
ATOM   2069 C CG2 . VAL B 2 189 ? -15.214 22.665 38.957  1.00 27.02 ? 189 VAL H CG2 1 
ATOM   2070 N N   . PRO B 2 190 ? -14.065 19.436 40.838  1.00 34.78 ? 190 PRO H N   1 
ATOM   2071 C CA  . PRO B 2 190 ? -15.004 18.635 41.631  1.00 39.46 ? 190 PRO H CA  1 
ATOM   2072 C C   . PRO B 2 190 ? -16.349 19.339 41.705  1.00 39.66 ? 190 PRO H C   1 
ATOM   2073 O O   . PRO B 2 190 ? -16.424 20.541 41.968  1.00 38.38 ? 190 PRO H O   1 
ATOM   2074 C CB  . PRO B 2 190 ? -14.325 18.552 43.002  1.00 43.14 ? 190 PRO H CB  1 
ATOM   2075 C CG  . PRO B 2 190 ? -12.871 18.698 42.700  1.00 39.89 ? 190 PRO H CG  1 
ATOM   2076 C CD  . PRO B 2 190 ? -12.793 19.660 41.551  1.00 35.52 ? 190 PRO H CD  1 
ATOM   2077 N N   . SER B 2 191 ? -17.419 18.589 41.441  1.00 38.15 ? 191 SER H N   1 
ATOM   2078 C CA  . SER B 2 191 ? -18.749 19.192 41.453  1.00 38.38 ? 191 SER H CA  1 
ATOM   2079 C C   . SER B 2 191 ? -19.080 19.804 42.810  1.00 39.05 ? 191 SER H C   1 
ATOM   2080 O O   . SER B 2 191 ? -19.897 20.728 42.892  1.00 41.89 ? 191 SER H O   1 
ATOM   2081 C CB  . SER B 2 191 ? -19.797 18.153 41.054  1.00 40.02 ? 191 SER H CB  1 
ATOM   2082 O OG  . SER B 2 191 ? -19.524 16.899 41.653  1.00 46.02 ? 191 SER H OG  1 
ATOM   2083 N N   . SER B 2 192 ? -18.440 19.326 43.878  1.00 40.59 ? 192 SER H N   1 
ATOM   2084 C CA  . SER B 2 192 ? -18.632 19.931 45.192  1.00 43.32 ? 192 SER H CA  1 
ATOM   2085 C C   . SER B 2 192 ? -17.993 21.314 45.276  1.00 44.27 ? 192 SER H C   1 
ATOM   2086 O O   . SER B 2 192 ? -18.494 22.187 45.997  1.00 43.79 ? 192 SER H O   1 
ATOM   2087 C CB  . SER B 2 192 ? -18.051 19.019 46.274  1.00 39.13 ? 192 SER H CB  1 
ATOM   2088 O OG  . SER B 2 192 ? -16.661 18.834 46.070  1.00 42.58 ? 192 SER H OG  1 
ATOM   2089 N N   . SER B 2 193 ? -16.890 21.536 44.553  1.00 38.56 ? 193 SER H N   1 
ATOM   2090 C CA  . SER B 2 193 ? -16.172 22.801 44.670  1.00 42.11 ? 193 SER H CA  1 
ATOM   2091 C C   . SER B 2 193 ? -16.994 23.989 44.185  1.00 42.35 ? 193 SER H C   1 
ATOM   2092 O O   . SER B 2 193 ? -16.625 25.138 44.458  1.00 44.30 ? 193 SER H O   1 
ATOM   2093 C CB  . SER B 2 193 ? -14.856 22.729 43.896  1.00 41.91 ? 193 SER H CB  1 
ATOM   2094 O OG  . SER B 2 193 ? -15.103 22.633 42.506  1.00 46.13 ? 193 SER H OG  1 
ATOM   2095 N N   . LEU B 2 194 ? -18.096 23.746 43.473  1.00 39.82 ? 194 LEU H N   1 
ATOM   2096 C CA  . LEU B 2 194 ? -18.930 24.835 42.984  1.00 40.12 ? 194 LEU H CA  1 
ATOM   2097 C C   . LEU B 2 194 ? -19.631 25.590 44.104  1.00 45.15 ? 194 LEU H C   1 
ATOM   2098 O O   . LEU B 2 194 ? -20.185 26.659 43.846  1.00 46.34 ? 194 LEU H O   1 
ATOM   2099 C CB  . LEU B 2 194 ? -19.976 24.304 42.001  1.00 36.68 ? 194 LEU H CB  1 
ATOM   2100 C CG  . LEU B 2 194 ? -19.516 23.444 40.824  1.00 37.17 ? 194 LEU H CG  1 
ATOM   2101 C CD1 . LEU B 2 194 ? -20.728 22.951 40.043  1.00 35.37 ? 194 LEU H CD1 1 
ATOM   2102 C CD2 . LEU B 2 194 ? -18.570 24.223 39.919  1.00 39.12 ? 194 LEU H CD2 1 
ATOM   2103 N N   . GLY B 2 195 ? -19.636 25.065 45.325  1.00 44.91 ? 195 GLY H N   1 
ATOM   2104 C CA  . GLY B 2 195 ? -20.270 25.722 46.445  1.00 43.87 ? 195 GLY H CA  1 
ATOM   2105 C C   . GLY B 2 195 ? -19.333 26.456 47.361  1.00 44.83 ? 195 GLY H C   1 
ATOM   2106 O O   . GLY B 2 195 ? -19.777 27.052 48.346  1.00 46.10 ? 195 GLY H O   1 
ATOM   2107 N N   . THR B 2 196 ? -18.042 26.428 47.072  1.00 41.83 ? 196 THR H N   1 
ATOM   2108 C CA  . THR B 2 196 ? -17.043 27.068 47.914  1.00 40.46 ? 196 THR H CA  1 
ATOM   2109 C C   . THR B 2 196 ? -16.062 27.928 47.138  1.00 38.79 ? 196 THR H C   1 
ATOM   2110 O O   . THR B 2 196 ? -15.365 28.744 47.752  1.00 37.07 ? 196 THR H O   1 
ATOM   2111 C CB  . THR B 2 196 ? -16.255 26.009 48.700  1.00 41.61 ? 196 THR H CB  1 
ATOM   2112 O OG1 . THR B 2 196 ? -15.871 24.950 47.812  1.00 44.13 ? 196 THR H OG1 1 
ATOM   2113 C CG2 . THR B 2 196 ? -17.103 25.450 49.840  1.00 40.62 ? 196 THR H CG2 1 
ATOM   2114 N N   . GLN B 2 197 ? -15.992 27.784 45.819  1.00 38.51 ? 197 GLN H N   1 
ATOM   2115 C CA  . GLN B 2 197 ? -14.994 28.448 45.000  1.00 35.36 ? 197 GLN H CA  1 
ATOM   2116 C C   . GLN B 2 197 ? -15.673 29.303 43.940  1.00 30.16 ? 197 GLN H C   1 
ATOM   2117 O O   . GLN B 2 197 ? -16.643 28.869 43.311  1.00 28.49 ? 197 GLN H O   1 
ATOM   2118 C CB  . GLN B 2 197 ? -14.072 27.408 44.336  1.00 36.38 ? 197 GLN H CB  1 
ATOM   2119 C CG  . GLN B 2 197 ? -12.966 28.010 43.488  1.00 33.74 ? 197 GLN H CG  1 
ATOM   2120 C CD  . GLN B 2 197 ? -12.050 28.904 44.296  1.00 35.52 ? 197 GLN H CD  1 
ATOM   2121 O OE1 . GLN B 2 197 ? -11.914 28.739 45.507  1.00 41.08 ? 197 GLN H OE1 1 
ATOM   2122 N NE2 . GLN B 2 197 ? -11.419 29.864 43.630  1.00 37.41 ? 197 GLN H NE2 1 
ATOM   2123 N N   . THR B 2 198 ? -15.166 30.519 43.756  1.00 29.07 ? 198 THR H N   1 
ATOM   2124 C CA  . THR B 2 198 ? -15.540 31.329 42.608  1.00 25.30 ? 198 THR H CA  1 
ATOM   2125 C C   . THR B 2 198 ? -14.531 31.115 41.486  1.00 24.60 ? 198 THR H C   1 
ATOM   2126 O O   . THR B 2 198 ? -13.332 30.941 41.721  1.00 23.27 ? 198 THR H O   1 
ATOM   2127 C CB  . THR B 2 198 ? -15.600 32.813 42.968  1.00 29.50 ? 198 THR H CB  1 
ATOM   2128 O OG1 . THR B 2 198 ? -14.302 33.404 42.803  1.00 36.44 ? 198 THR H OG1 1 
ATOM   2129 C CG2 . THR B 2 198 ? -16.023 32.985 44.406  1.00 31.09 ? 198 THR H CG2 1 
ATOM   2130 N N   . TYR B 2 199 ? -15.023 31.145 40.257  1.00 20.71 ? 199 TYR H N   1 
ATOM   2131 C CA  . TYR B 2 199 ? -14.204 30.907 39.075  1.00 20.74 ? 199 TYR H CA  1 
ATOM   2132 C C   . TYR B 2 199 ? -14.289 32.126 38.173  1.00 19.84 ? 199 TYR H C   1 
ATOM   2133 O O   . TYR B 2 199 ? -15.380 32.481 37.710  1.00 18.97 ? 199 TYR H O   1 
ATOM   2134 C CB  . TYR B 2 199 ? -14.664 29.647 38.342  1.00 18.62 ? 199 TYR H CB  1 
ATOM   2135 C CG  . TYR B 2 199 ? -14.583 28.426 39.230  1.00 22.22 ? 199 TYR H CG  1 
ATOM   2136 C CD1 . TYR B 2 199 ? -13.403 27.718 39.346  1.00 26.85 ? 199 TYR H CD1 1 
ATOM   2137 C CD2 . TYR B 2 199 ? -15.675 28.013 39.986  1.00 28.59 ? 199 TYR H CD2 1 
ATOM   2138 C CE1 . TYR B 2 199 ? -13.308 26.613 40.167  1.00 27.78 ? 199 TYR H CE1 1 
ATOM   2139 C CE2 . TYR B 2 199 ? -15.591 26.903 40.816  1.00 31.58 ? 199 TYR H CE2 1 
ATOM   2140 C CZ  . TYR B 2 199 ? -14.401 26.209 40.900  1.00 30.14 ? 199 TYR H CZ  1 
ATOM   2141 O OH  . TYR B 2 199 ? -14.285 25.105 41.724  1.00 32.81 ? 199 TYR H OH  1 
ATOM   2142 N N   . ILE B 2 200 ? -13.142 32.765 37.939  1.00 16.74 ? 200 ILE H N   1 
ATOM   2143 C CA  . ILE B 2 200 ? -13.037 33.953 37.102  1.00 17.66 ? 200 ILE H CA  1 
ATOM   2144 C C   . ILE B 2 200 ? -12.031 33.679 35.996  1.00 19.09 ? 200 ILE H C   1 
ATOM   2145 O O   . ILE B 2 200 ? -10.881 33.321 36.275  1.00 16.54 ? 200 ILE H O   1 
ATOM   2146 C CB  . ILE B 2 200 ? -12.602 35.183 37.914  1.00 18.82 ? 200 ILE H CB  1 
ATOM   2147 C CG1 . ILE B 2 200 ? -13.583 35.433 39.068  1.00 20.95 ? 200 ILE H CG1 1 
ATOM   2148 C CG2 . ILE B 2 200 ? -12.447 36.382 36.997  1.00 18.65 ? 200 ILE H CG2 1 
ATOM   2149 C CD1 . ILE B 2 200 ? -13.070 36.426 40.071  1.00 21.69 ? 200 ILE H CD1 1 
ATOM   2150 N N   . CYS B 2 201 ? -12.441 33.875 34.744  1.00 14.87 ? 201 CYS H N   1 
ATOM   2151 C CA  . CYS B 2 201 ? -11.502 33.755 33.639  1.00 17.27 ? 201 CYS H CA  1 
ATOM   2152 C C   . CYS B 2 201 ? -10.968 35.134 33.280  1.00 17.50 ? 201 CYS H C   1 
ATOM   2153 O O   . CYS B 2 201 ? -11.737 36.098 33.141  1.00 18.49 ? 201 CYS H O   1 
ATOM   2154 C CB  . CYS B 2 201 ? -12.142 33.080 32.430  1.00 18.28 ? 201 CYS H CB  1 
ATOM   2155 S SG  . CYS B 2 201 ? -13.302 34.102 31.557  1.00 20.24 ? 201 CYS H SG  1 
ATOM   2156 N N   . ASN B 2 202 ? -9.645  35.227 33.170  1.00 17.92 ? 202 ASN H N   1 
ATOM   2157 C CA  . ASN B 2 202 ? -8.960  36.482 32.897  1.00 16.70 ? 202 ASN H CA  1 
ATOM   2158 C C   . ASN B 2 202 ? -8.551  36.477 31.432  1.00 21.09 ? 202 ASN H C   1 
ATOM   2159 O O   . ASN B 2 202 ? -7.635  35.750 31.043  1.00 18.15 ? 202 ASN H O   1 
ATOM   2160 C CB  . ASN B 2 202 ? -7.750  36.639 33.806  1.00 15.26 ? 202 ASN H CB  1 
ATOM   2161 C CG  . ASN B 2 202 ? -8.011  36.133 35.197  1.00 19.35 ? 202 ASN H CG  1 
ATOM   2162 O OD1 . ASN B 2 202 ? -7.454  35.116 35.605  1.00 18.59 ? 202 ASN H OD1 1 
ATOM   2163 N ND2 . ASN B 2 202 ? -8.866  36.829 35.934  1.00 17.76 ? 202 ASN H ND2 1 
ATOM   2164 N N   . VAL B 2 203 ? -9.239  37.280 30.624  1.00 18.69 ? 203 VAL H N   1 
ATOM   2165 C CA  . VAL B 2 203 ? -9.008  37.344 29.186  1.00 19.10 ? 203 VAL H CA  1 
ATOM   2166 C C   . VAL B 2 203 ? -8.210  38.607 28.898  1.00 22.76 ? 203 VAL H C   1 
ATOM   2167 O O   . VAL B 2 203 ? -8.519  39.678 29.432  1.00 20.66 ? 203 VAL H O   1 
ATOM   2168 C CB  . VAL B 2 203 ? -10.340 37.332 28.415  1.00 17.48 ? 203 VAL H CB  1 
ATOM   2169 C CG1 . VAL B 2 203 ? -10.110 37.418 26.921  1.00 17.59 ? 203 VAL H CG1 1 
ATOM   2170 C CG2 . VAL B 2 203 ? -11.140 36.077 28.754  1.00 19.73 ? 203 VAL H CG2 1 
ATOM   2171 N N   . ASN B 2 204 ? -7.167  38.489 28.081  1.00 21.09 ? 204 ASN H N   1 
ATOM   2172 C CA  . ASN B 2 204 ? -6.452  39.666 27.610  1.00 21.99 ? 204 ASN H CA  1 
ATOM   2173 C C   . ASN B 2 204 ? -6.312  39.585 26.097  1.00 22.32 ? 204 ASN H C   1 
ATOM   2174 O O   . ASN B 2 204 ? -5.948  38.538 25.560  1.00 18.79 ? 204 ASN H O   1 
ATOM   2175 C CB  . ASN B 2 204 ? -5.079  39.803 28.276  1.00 25.62 ? 204 ASN H CB  1 
ATOM   2176 C CG  . ASN B 2 204 ? -4.625  41.255 28.380  1.00 31.64 ? 204 ASN H CG  1 
ATOM   2177 O OD1 . ASN B 2 204 ? -3.765  41.594 29.195  1.00 39.15 ? 204 ASN H OD1 1 
ATOM   2178 N ND2 . ASN B 2 204 ? -5.221  42.125 27.565  1.00 33.28 ? 204 ASN H ND2 1 
ATOM   2179 N N   . HIS B 2 205 ? -6.637  40.677 25.415  1.00 21.39 ? 205 HIS H N   1 
ATOM   2180 C CA  . HIS B 2 205 ? -6.380  40.833 23.984  1.00 20.03 ? 205 HIS H CA  1 
ATOM   2181 C C   . HIS B 2 205 ? -5.556  42.114 23.866  1.00 21.11 ? 205 HIS H C   1 
ATOM   2182 O O   . HIS B 2 205 ? -6.102  43.217 23.757  1.00 20.59 ? 205 HIS H O   1 
ATOM   2183 C CB  . HIS B 2 205 ? -7.683  40.886 23.181  1.00 19.04 ? 205 HIS H CB  1 
ATOM   2184 C CG  . HIS B 2 205 ? -7.491  40.970 21.699  1.00 18.33 ? 205 HIS H CG  1 
ATOM   2185 N ND1 . HIS B 2 205 ? -7.941  42.040 20.957  1.00 18.81 ? 205 HIS H ND1 1 
ATOM   2186 C CD2 . HIS B 2 205 ? -6.937  40.105 20.816  1.00 19.03 ? 205 HIS H CD2 1 
ATOM   2187 C CE1 . HIS B 2 205 ? -7.659  41.839 19.681  1.00 18.82 ? 205 HIS H CE1 1 
ATOM   2188 N NE2 . HIS B 2 205 ? -7.048  40.673 19.568  1.00 18.28 ? 205 HIS H NE2 1 
ATOM   2189 N N   . LYS B 2 206 ? -4.236  41.962 23.937  1.00 22.80 ? 206 LYS H N   1 
ATOM   2190 C CA  . LYS B 2 206 ? -3.340  43.109 23.843  1.00 25.13 ? 206 LYS H CA  1 
ATOM   2191 C C   . LYS B 2 206 ? -3.567  43.971 22.606  1.00 21.88 ? 206 LYS H C   1 
ATOM   2192 O O   . LYS B 2 206 ? -3.537  45.207 22.745  1.00 24.46 ? 206 LYS H O   1 
ATOM   2193 C CB  . LYS B 2 206 ? -1.886  42.614 23.912  1.00 25.50 ? 206 LYS H CB  1 
ATOM   2194 C CG  . LYS B 2 206 ? -1.625  41.602 25.026  1.00 29.85 ? 206 LYS H CG  1 
ATOM   2195 C CD  . LYS B 2 206 ? -0.956  42.219 26.251  1.00 36.17 ? 206 LYS H CD  1 
ATOM   2196 C CE  . LYS B 2 206 ? -1.924  43.077 27.061  1.00 37.29 ? 206 LYS H CE  1 
ATOM   2197 N NZ  . LYS B 2 206 ? -1.392  43.402 28.419  1.00 37.00 ? 206 LYS H NZ  1 
ATOM   2198 N N   . PRO B 2 207 ? -3.796  43.427 21.402  1.00 23.20 ? 207 PRO H N   1 
ATOM   2199 C CA  . PRO B 2 207 ? -3.965  44.307 20.232  1.00 25.33 ? 207 PRO H CA  1 
ATOM   2200 C C   . PRO B 2 207 ? -5.063  45.340 20.373  1.00 23.07 ? 207 PRO H C   1 
ATOM   2201 O O   . PRO B 2 207 ? -4.974  46.395 19.735  1.00 28.76 ? 207 PRO H O   1 
ATOM   2202 C CB  . PRO B 2 207 ? -4.262  43.324 19.097  1.00 22.81 ? 207 PRO H CB  1 
ATOM   2203 C CG  . PRO B 2 207 ? -3.580  42.089 19.496  1.00 21.75 ? 207 PRO H CG  1 
ATOM   2204 C CD  . PRO B 2 207 ? -3.716  42.013 20.994  1.00 21.67 ? 207 PRO H CD  1 
ATOM   2205 N N   . SER B 2 208 ? -6.080  45.100 21.201  1.00 21.98 ? 208 SER H N   1 
ATOM   2206 C CA  . SER B 2 208 ? -7.163  46.061 21.394  1.00 21.26 ? 208 SER H CA  1 
ATOM   2207 C C   . SER B 2 208 ? -7.201  46.651 22.798  1.00 22.13 ? 208 SER H C   1 
ATOM   2208 O O   . SER B 2 208 ? -8.160  47.350 23.135  1.00 22.45 ? 208 SER H O   1 
ATOM   2209 C CB  . SER B 2 208 ? -8.510  45.408 21.085  1.00 19.87 ? 208 SER H CB  1 
ATOM   2210 O OG  . SER B 2 208 ? -8.767  44.365 22.010  1.00 19.10 ? 208 SER H OG  1 
ATOM   2211 N N   . ASN B 2 209 ? -6.184  46.395 23.620  1.00 22.66 ? 209 ASN H N   1 
ATOM   2212 C CA  . ASN B 2 209 ? -6.190  46.823 25.015  1.00 22.17 ? 209 ASN H CA  1 
ATOM   2213 C C   . ASN B 2 209 ? -7.466  46.386 25.725  1.00 22.76 ? 209 ASN H C   1 
ATOM   2214 O O   . ASN B 2 209 ? -8.017  47.111 26.552  1.00 22.31 ? 209 ASN H O   1 
ATOM   2215 C CB  . ASN B 2 209 ? -5.999  48.336 25.133  1.00 26.43 ? 209 ASN H CB  1 
ATOM   2216 C CG  . ASN B 2 209 ? -4.536  48.739 25.166  1.00 29.65 ? 209 ASN H CG  1 
ATOM   2217 O OD1 . ASN B 2 209 ? -3.638  47.896 25.125  1.00 31.82 ? 209 ASN H OD1 1 
ATOM   2218 N ND2 . ASN B 2 209 ? -4.290  50.043 25.242  1.00 38.13 ? 209 ASN H ND2 1 
ATOM   2219 N N   . THR B 2 210 ? -7.934  45.178 25.411  1.00 21.50 ? 210 THR H N   1 
ATOM   2220 C CA  . THR B 2 210 ? -9.107  44.598 26.053  1.00 21.17 ? 210 THR H CA  1 
ATOM   2221 C C   . THR B 2 210 ? -8.657  43.687 27.186  1.00 20.88 ? 210 THR H C   1 
ATOM   2222 O O   . THR B 2 210 ? -7.895  42.743 26.958  1.00 22.31 ? 210 THR H O   1 
ATOM   2223 C CB  . THR B 2 210 ? -9.958  43.800 25.064  1.00 19.12 ? 210 THR H CB  1 
ATOM   2224 O OG1 . THR B 2 210 ? -10.478 44.672 24.057  1.00 22.78 ? 210 THR H OG1 1 
ATOM   2225 C CG2 . THR B 2 210 ? -11.117 43.143 25.792  1.00 19.02 ? 210 THR H CG2 1 
ATOM   2226 N N   . LYS B 2 211 ? -9.129  43.970 28.396  1.00 20.28 ? 211 LYS H N   1 
ATOM   2227 C CA  . LYS B 2 211 ? -8.889  43.119 29.558  1.00 22.53 ? 211 LYS H CA  1 
ATOM   2228 C C   . LYS B 2 211 ? -10.226 42.862 30.223  1.00 24.65 ? 211 LYS H C   1 
ATOM   2229 O O   . LYS B 2 211 ? -10.881 43.802 30.682  1.00 26.78 ? 211 LYS H O   1 
ATOM   2230 C CB  . LYS B 2 211 ? -7.926  43.762 30.561  1.00 26.48 ? 211 LYS H CB  1 
ATOM   2231 C CG  . LYS B 2 211 ? -6.459  43.586 30.254  1.00 32.59 ? 211 LYS H CG  1 
ATOM   2232 C CD  . LYS B 2 211 ? -5.611  44.147 31.390  1.00 35.00 ? 211 LYS H CD  1 
ATOM   2233 C CE  . LYS B 2 211 ? -4.131  44.182 31.030  1.00 39.67 ? 211 LYS H CE  1 
ATOM   2234 N NZ  . LYS B 2 211 ? -3.319  45.023 31.965  1.00 43.69 ? 211 LYS H NZ  1 
ATOM   2235 N N   . VAL B 2 212 ? -10.624 41.596 30.282  1.00 22.48 ? 212 VAL H N   1 
ATOM   2236 C CA  . VAL B 2 212 ? -11.909 41.198 30.839  1.00 22.42 ? 212 VAL H CA  1 
ATOM   2237 C C   . VAL B 2 212 ? -11.670 40.109 31.877  1.00 23.56 ? 212 VAL H C   1 
ATOM   2238 O O   . VAL B 2 212 ? -10.981 39.121 31.597  1.00 20.00 ? 212 VAL H O   1 
ATOM   2239 C CB  . VAL B 2 212 ? -12.864 40.696 29.742  1.00 21.48 ? 212 VAL H CB  1 
ATOM   2240 C CG1 . VAL B 2 212 ? -14.160 40.208 30.359  1.00 27.54 ? 212 VAL H CG1 1 
ATOM   2241 C CG2 . VAL B 2 212 ? -13.133 41.790 28.740  1.00 25.94 ? 212 VAL H CG2 1 
ATOM   2242 N N   . ASP B 2 213 ? -12.225 40.298 33.072  1.00 21.59 ? 213 ASP H N   1 
ATOM   2243 C CA  . ASP B 2 213 ? -12.209 39.301 34.141  1.00 18.74 ? 213 ASP H CA  1 
ATOM   2244 C C   . ASP B 2 213 ? -13.656 38.873 34.336  1.00 23.35 ? 213 ASP H C   1 
ATOM   2245 O O   . ASP B 2 213 ? -14.424 39.560 35.018  1.00 22.82 ? 213 ASP H O   1 
ATOM   2246 C CB  . ASP B 2 213 ? -11.612 39.870 35.427  1.00 21.09 ? 213 ASP H CB  1 
ATOM   2247 C CG  . ASP B 2 213 ? -10.145 40.255 35.283  1.00 24.90 ? 213 ASP H CG  1 
ATOM   2248 O OD1 . ASP B 2 213 ? -9.332  39.420 34.843  1.00 23.17 ? 213 ASP H OD1 1 
ATOM   2249 O OD2 . ASP B 2 213 ? -9.797  41.405 35.616  1.00 27.13 ? 213 ASP H OD2 1 
ATOM   2250 N N   . LYS B 2 214 ? -14.041 37.756 33.722  1.00 19.59 ? 214 LYS H N   1 
ATOM   2251 C CA  . LYS B 2 214 ? -15.429 37.314 33.744  1.00 18.06 ? 214 LYS H CA  1 
ATOM   2252 C C   . LYS B 2 214 ? -15.632 36.233 34.798  1.00 20.50 ? 214 LYS H C   1 
ATOM   2253 O O   . LYS B 2 214 ? -15.058 35.143 34.701  1.00 17.39 ? 214 LYS H O   1 
ATOM   2254 C CB  . LYS B 2 214 ? -15.871 36.805 32.377  1.00 19.39 ? 214 LYS H CB  1 
ATOM   2255 C CG  . LYS B 2 214 ? -17.279 36.212 32.420  1.00 20.97 ? 214 LYS H CG  1 
ATOM   2256 C CD  . LYS B 2 214 ? -18.280 36.984 31.579  1.00 28.54 ? 214 LYS H CD  1 
ATOM   2257 C CE  . LYS B 2 214 ? -18.469 38.410 32.064  1.00 29.09 ? 214 LYS H CE  1 
ATOM   2258 N NZ  . LYS B 2 214 ? -19.531 39.120 31.276  1.00 32.88 ? 214 LYS H NZ  1 
ATOM   2259 N N   . ARG B 2 215 ? -16.479 36.521 35.779  1.00 17.64 ? 215 ARG H N   1 
ATOM   2260 C CA  . ARG B 2 215 ? -16.878 35.507 36.741  1.00 19.24 ? 215 ARG H CA  1 
ATOM   2261 C C   . ARG B 2 215 ? -17.874 34.542 36.102  1.00 22.06 ? 215 ARG H C   1 
ATOM   2262 O O   . ARG B 2 215 ? -18.860 34.967 35.489  1.00 20.98 ? 215 ARG H O   1 
ATOM   2263 C CB  . ARG B 2 215 ? -17.492 36.164 37.976  1.00 20.47 ? 215 ARG H CB  1 
ATOM   2264 C CG  . ARG B 2 215 ? -18.197 35.179 38.857  1.00 23.13 ? 215 ARG H CG  1 
ATOM   2265 C CD  . ARG B 2 215 ? -18.307 35.678 40.271  1.00 22.21 ? 215 ARG H CD  1 
ATOM   2266 N NE  . ARG B 2 215 ? -19.098 34.740 41.056  1.00 25.74 ? 215 ARG H NE  1 
ATOM   2267 C CZ  . ARG B 2 215 ? -19.261 34.798 42.368  1.00 27.42 ? 215 ARG H CZ  1 
ATOM   2268 N NH1 . ARG B 2 215 ? -18.658 35.727 43.092  1.00 31.32 ? 215 ARG H NH1 1 
ATOM   2269 N NH2 . ARG B 2 215 ? -20.055 33.907 42.964  1.00 28.81 ? 215 ARG H NH2 1 
ATOM   2270 N N   . VAL B 2 216 ? -17.620 33.244 36.237  1.00 17.40 ? 216 VAL H N   1 
ATOM   2271 C CA  . VAL B 2 216 ? -18.502 32.222 35.695  1.00 19.36 ? 216 VAL H CA  1 
ATOM   2272 C C   . VAL B 2 216 ? -19.293 31.628 36.848  1.00 23.73 ? 216 VAL H C   1 
ATOM   2273 O O   . VAL B 2 216 ? -18.725 30.984 37.735  1.00 24.78 ? 216 VAL H O   1 
ATOM   2274 C CB  . VAL B 2 216 ? -17.721 31.143 34.946  1.00 19.86 ? 216 VAL H CB  1 
ATOM   2275 C CG1 . VAL B 2 216 ? -18.682 30.159 34.325  1.00 17.81 ? 216 VAL H CG1 1 
ATOM   2276 C CG2 . VAL B 2 216 ? -16.833 31.793 33.900  1.00 18.03 ? 216 VAL H CG2 1 
ATOM   2277 N N   . GLU B 2 217 ? -20.605 31.841 36.837  1.00 22.41 ? 217 GLU H N   1 
ATOM   2278 C CA  . GLU B 2 217 ? -21.437 31.424 37.949  1.00 29.94 ? 217 GLU H CA  1 
ATOM   2279 C C   . GLU B 2 217 ? -22.229 30.182 37.579  1.00 28.16 ? 217 GLU H C   1 
ATOM   2280 O O   . GLU B 2 217 ? -22.859 30.148 36.513  1.00 27.88 ? 217 GLU H O   1 
ATOM   2281 C CB  . GLU B 2 217 ? -22.387 32.566 38.364  1.00 31.26 ? 217 GLU H CB  1 
ATOM   2282 C CG  . GLU B 2 217 ? -23.245 32.283 39.589  1.00 35.06 ? 217 GLU H CG  1 
ATOM   2283 C CD  . GLU B 2 217 ? -22.463 32.268 40.898  1.00 36.31 ? 217 GLU H CD  1 
ATOM   2284 O OE1 . GLU B 2 217 ? -21.213 32.268 40.866  1.00 36.12 ? 217 GLU H OE1 1 
ATOM   2285 O OE2 . GLU B 2 217 ? -23.111 32.260 41.970  1.00 34.11 ? 217 GLU H OE2 1 
ATOM   2286 N N   . PRO B 2 218 ? -22.178 29.133 38.398  1.00 32.08 ? 218 PRO H N   1 
ATOM   2287 C CA  . PRO B 2 218 ? -23.027 27.962 38.149  1.00 31.65 ? 218 PRO H CA  1 
ATOM   2288 C C   . PRO B 2 218 ? -24.499 28.344 38.127  1.00 35.26 ? 218 PRO H C   1 
ATOM   2289 O O   . PRO B 2 218 ? -24.978 29.115 38.963  1.00 35.90 ? 218 PRO H O   1 
ATOM   2290 C CB  . PRO B 2 218 ? -22.697 27.034 39.322  1.00 32.74 ? 218 PRO H CB  1 
ATOM   2291 C CG  . PRO B 2 218 ? -21.288 27.407 39.689  1.00 32.29 ? 218 PRO H CG  1 
ATOM   2292 C CD  . PRO B 2 218 ? -21.212 28.898 39.489  1.00 32.08 ? 218 PRO H CD  1 
ATOM   2293 N N   . LYS B 2 219 ? -25.214 27.808 37.147  1.00 34.37 ? 219 LYS H N   1 
ATOM   2294 C CA  . LYS B 2 219 ? -26.616 28.151 36.963  1.00 39.69 ? 219 LYS H CA  1 
ATOM   2295 C C   . LYS B 2 219 ? -27.543 27.201 37.731  1.00 41.32 ? 219 LYS H C   1 
ATOM   2296 O O   . LYS B 2 219 ? -27.577 25.995 37.474  1.00 46.49 ? 219 LYS H O   1 
ATOM   2297 C CB  . LYS B 2 219 ? -26.961 28.150 35.472  1.00 38.64 ? 219 LYS H CB  1 
ATOM   2298 C CG  . LYS B 2 219 ? -28.449 28.272 35.185  1.00 44.41 ? 219 LYS H CG  1 
ATOM   2299 C CD  . LYS B 2 219 ? -28.917 29.722 35.112  1.00 44.64 ? 219 LYS H CD  1 
ATOM   2300 C CE  . LYS B 2 219 ? -29.144 30.170 33.665  1.00 45.59 ? 219 LYS H CE  1 
ATOM   2301 N NZ  . LYS B 2 219 ? -30.531 29.889 33.167  1.00 49.77 ? 219 LYS H NZ  1 
ATOM   2302 N N   . GLU C 3 1   ? 5.063   15.739 -12.327 1.00 34.24 ? 1   GLU L N   1 
ATOM   2303 C CA  . GLU C 3 1   ? 5.012   16.195 -10.939 1.00 32.24 ? 1   GLU L CA  1 
ATOM   2304 C C   . GLU C 3 1   ? 4.944   15.003 -9.999  1.00 28.23 ? 1   GLU L C   1 
ATOM   2305 O O   . GLU C 3 1   ? 4.025   14.184 -10.057 1.00 28.33 ? 1   GLU L O   1 
ATOM   2306 C CB  . GLU C 3 1   ? 3.826   17.127 -10.731 1.00 33.19 ? 1   GLU L CB  1 
ATOM   2307 C CG  . GLU C 3 1   ? 3.019   16.915 -9.445  1.00 38.18 ? 1   GLU L CG  1 
ATOM   2308 C CD  . GLU C 3 1   ? 1.546   17.202 -9.685  1.00 41.80 ? 1   GLU L CD  1 
ATOM   2309 O OE1 . GLU C 3 1   ? 1.195   17.443 -10.862 1.00 43.96 ? 1   GLU L OE1 1 
ATOM   2310 O OE2 . GLU C 3 1   ? 0.746   17.193 -8.718  1.00 43.38 ? 1   GLU L OE2 1 
ATOM   2311 N N   . ILE C 3 2   ? 5.939   14.886 -9.135  1.00 24.69 ? 2   ILE L N   1 
ATOM   2312 C CA  . ILE C 3 2   ? 6.077   13.702 -8.298  1.00 20.92 ? 2   ILE L CA  1 
ATOM   2313 C C   . ILE C 3 2   ? 5.273   13.914 -7.025  1.00 21.75 ? 2   ILE L C   1 
ATOM   2314 O O   . ILE C 3 2   ? 5.452   14.913 -6.321  1.00 18.18 ? 2   ILE L O   1 
ATOM   2315 C CB  . ILE C 3 2   ? 7.550   13.406 -7.998  1.00 19.52 ? 2   ILE L CB  1 
ATOM   2316 C CG1 . ILE C 3 2   ? 8.300   13.177 -9.310  1.00 22.66 ? 2   ILE L CG1 1 
ATOM   2317 C CG2 . ILE C 3 2   ? 7.681   12.203 -7.086  1.00 19.06 ? 2   ILE L CG2 1 
ATOM   2318 C CD1 . ILE C 3 2   ? 9.749   12.857 -9.132  1.00 25.09 ? 2   ILE L CD1 1 
ATOM   2319 N N   . VAL C 3 3   ? 4.380   12.977 -6.734  1.00 19.65 ? 3   VAL L N   1 
ATOM   2320 C CA  . VAL C 3 3   ? 3.495   13.053 -5.579  1.00 18.82 ? 3   VAL L CA  1 
ATOM   2321 C C   . VAL C 3 3   ? 3.970   12.029 -4.563  1.00 18.36 ? 3   VAL L C   1 
ATOM   2322 O O   . VAL C 3 3   ? 4.246   10.875 -4.920  1.00 18.92 ? 3   VAL L O   1 
ATOM   2323 C CB  . VAL C 3 3   ? 2.029   12.809 -5.978  1.00 19.25 ? 3   VAL L CB  1 
ATOM   2324 C CG1 . VAL C 3 3   ? 1.142   12.815 -4.750  1.00 18.72 ? 3   VAL L CG1 1 
ATOM   2325 C CG2 . VAL C 3 3   ? 1.572   13.874 -6.975  1.00 22.76 ? 3   VAL L CG2 1 
ATOM   2326 N N   . LEU C 3 4   ? 4.097   12.448 -3.308  1.00 15.03 ? 4   LEU L N   1 
ATOM   2327 C CA  . LEU C 3 4   ? 4.493   11.562 -2.219  1.00 14.89 ? 4   LEU L CA  1 
ATOM   2328 C C   . LEU C 3 4   ? 3.302   11.309 -1.304  1.00 13.40 ? 4   LEU L C   1 
ATOM   2329 O O   . LEU C 3 4   ? 2.590   12.244 -0.935  1.00 15.31 ? 4   LEU L O   1 
ATOM   2330 C CB  . LEU C 3 4   ? 5.649   12.150 -1.407  1.00 13.52 ? 4   LEU L CB  1 
ATOM   2331 C CG  . LEU C 3 4   ? 6.836   12.639 -2.226  1.00 18.30 ? 4   LEU L CG  1 
ATOM   2332 C CD1 . LEU C 3 4   ? 7.845   13.276 -1.340  1.00 19.58 ? 4   LEU L CD1 1 
ATOM   2333 C CD2 . LEU C 3 4   ? 7.477   11.518 -2.865  1.00 20.71 ? 4   LEU L CD2 1 
ATOM   2334 N N   . THR C 3 5   ? 3.098   10.049 -0.931  1.00 14.92 ? 5   THR L N   1 
ATOM   2335 C CA  . THR C 3 5   ? 2.001   9.650  -0.058  1.00 15.42 ? 5   THR L CA  1 
ATOM   2336 C C   . THR C 3 5   ? 2.585   8.932  1.144   1.00 14.12 ? 5   THR L C   1 
ATOM   2337 O O   . THR C 3 5   ? 3.289   7.936  0.987   1.00 17.58 ? 5   THR L O   1 
ATOM   2338 C CB  . THR C 3 5   ? 1.011   8.744  -0.799  1.00 16.90 ? 5   THR L CB  1 
ATOM   2339 O OG1 . THR C 3 5   ? 0.424   9.480  -1.875  1.00 20.10 ? 5   THR L OG1 1 
ATOM   2340 C CG2 . THR C 3 5   ? -0.090  8.274  0.136   1.00 18.08 ? 5   THR L CG2 1 
ATOM   2341 N N   . GLN C 3 6   ? 2.275   9.416  2.337   1.00 14.56 ? 6   GLN L N   1 
ATOM   2342 C CA  . GLN C 3 6   ? 2.782   8.797  3.550   1.00 13.71 ? 6   GLN L CA  1 
ATOM   2343 C C   . GLN C 3 6   ? 1.716   7.946  4.227   1.00 14.56 ? 6   GLN L C   1 
ATOM   2344 O O   . GLN C 3 6   ? 0.511   8.185  4.092   1.00 16.01 ? 6   GLN L O   1 
ATOM   2345 C CB  . GLN C 3 6   ? 3.293   9.857  4.517   1.00 13.03 ? 6   GLN L CB  1 
ATOM   2346 C CG  . GLN C 3 6   ? 4.607   10.460 4.068   1.00 11.99 ? 6   GLN L CG  1 
ATOM   2347 C CD  . GLN C 3 6   ? 5.074   11.559 4.992   1.00 13.26 ? 6   GLN L CD  1 
ATOM   2348 O OE1 . GLN C 3 6   ? 5.075   12.728 4.618   1.00 11.51 ? 6   GLN L OE1 1 
ATOM   2349 N NE2 . GLN C 3 6   ? 5.450   11.192 6.223   1.00 12.71 ? 6   GLN L NE2 1 
ATOM   2350 N N   . SER C 3 7   ? 2.180   6.944  4.960   1.00 14.16 ? 7   SER L N   1 
ATOM   2351 C CA  . SER C 3 7   ? 1.290   6.080  5.725   1.00 15.74 ? 7   SER L CA  1 
ATOM   2352 C C   . SER C 3 7   ? 2.062   5.560  6.922   1.00 14.45 ? 7   SER L C   1 
ATOM   2353 O O   . SER C 3 7   ? 3.289   5.400  6.848   1.00 15.15 ? 7   SER L O   1 
ATOM   2354 C CB  . SER C 3 7   ? 0.773   4.908  4.887   1.00 16.30 ? 7   SER L CB  1 
ATOM   2355 O OG  . SER C 3 7   ? 1.851   4.098  4.494   1.00 20.21 ? 7   SER L OG  1 
ATOM   2356 N N   . PRO C 3 8   ? 1.395   5.358  8.051   1.00 15.10 ? 8   PRO L N   1 
ATOM   2357 C CA  . PRO C 3 8   ? 0.000   5.699  8.342   1.00 15.33 ? 8   PRO L CA  1 
ATOM   2358 C C   . PRO C 3 8   ? -0.129  7.189  8.620   1.00 15.32 ? 8   PRO L C   1 
ATOM   2359 O O   . PRO C 3 8   ? 0.883   7.881  8.717   1.00 16.31 ? 8   PRO L O   1 
ATOM   2360 C CB  . PRO C 3 8   ? -0.295  4.855  9.585   1.00 17.76 ? 8   PRO L CB  1 
ATOM   2361 C CG  . PRO C 3 8   ? 1.023   4.876  10.318  1.00 16.61 ? 8   PRO L CG  1 
ATOM   2362 C CD  . PRO C 3 8   ? 2.076   4.805  9.235   1.00 16.58 ? 8   PRO L CD  1 
ATOM   2363 N N   . GLY C 3 9   ? -1.343  7.718  8.768   1.00 13.75 ? 9   GLY L N   1 
ATOM   2364 C CA  . GLY C 3 9   ? -1.481  9.126  9.110   1.00 14.48 ? 9   GLY L CA  1 
ATOM   2365 C C   . GLY C 3 9   ? -0.996  9.418  10.514  1.00 15.50 ? 9   GLY L C   1 
ATOM   2366 O O   . GLY C 3 9   ? -0.351  10.442 10.759  1.00 15.68 ? 9   GLY L O   1 
ATOM   2367 N N   . THR C 3 10  ? -1.288  8.518  11.450  1.00 18.71 ? 10  THR L N   1 
ATOM   2368 C CA  . THR C 3 10  ? -0.817  8.603  12.825  1.00 16.45 ? 10  THR L CA  1 
ATOM   2369 C C   . THR C 3 10  ? -0.279  7.246  13.265  1.00 14.92 ? 10  THR L C   1 
ATOM   2370 O O   . THR C 3 10  ? -0.916  6.217  13.019  1.00 17.67 ? 10  THR L O   1 
ATOM   2371 C CB  . THR C 3 10  ? -1.942  9.037  13.767  1.00 17.01 ? 10  THR L CB  1 
ATOM   2372 O OG1 . THR C 3 10  ? -2.546  10.237 13.271  1.00 19.53 ? 10  THR L OG1 1 
ATOM   2373 C CG2 . THR C 3 10  ? -1.393  9.294  15.161  1.00 15.21 ? 10  THR L CG2 1 
ATOM   2374 N N   . LEU C 3 11  ? 0.897   7.251  13.886  1.00 14.24 ? 11  LEU L N   1 
ATOM   2375 C CA  . LEU C 3 11  ? 1.449   6.113  14.614  1.00 13.42 ? 11  LEU L CA  1 
ATOM   2376 C C   . LEU C 3 11  ? 1.337   6.411  16.099  1.00 14.84 ? 11  LEU L C   1 
ATOM   2377 O O   . LEU C 3 11  ? 1.767   7.479  16.541  1.00 15.44 ? 11  LEU L O   1 
ATOM   2378 C CB  . LEU C 3 11  ? 2.926   5.886  14.280  1.00 14.27 ? 11  LEU L CB  1 
ATOM   2379 C CG  . LEU C 3 11  ? 3.401   4.983  13.172  1.00 18.19 ? 11  LEU L CG  1 
ATOM   2380 C CD1 . LEU C 3 11  ? 4.927   5.005  13.163  1.00 15.02 ? 11  LEU L CD1 1 
ATOM   2381 C CD2 . LEU C 3 11  ? 2.886   3.592  13.443  1.00 18.37 ? 11  LEU L CD2 1 
ATOM   2382 N N   . SER C 3 12  ? 0.802   5.465  16.874  1.00 14.92 ? 12  SER L N   1 
ATOM   2383 C CA  . SER C 3 12  ? 0.642   5.640  18.320  1.00 13.63 ? 12  SER L CA  1 
ATOM   2384 C C   . SER C 3 12  ? 1.539   4.643  19.045  1.00 14.90 ? 12  SER L C   1 
ATOM   2385 O O   . SER C 3 12  ? 1.272   3.435  19.038  1.00 15.29 ? 12  SER L O   1 
ATOM   2386 C CB  . SER C 3 12  ? -0.816  5.461  18.729  1.00 17.08 ? 12  SER L CB  1 
ATOM   2387 O OG  . SER C 3 12  ? -1.680  6.180  17.863  1.00 15.80 ? 12  SER L OG  1 
ATOM   2388 N N   . LEU C 3 13  ? 2.587   5.149  19.691  1.00 14.43 ? 13  LEU L N   1 
ATOM   2389 C CA  . LEU C 3 13  ? 3.621   4.310  20.274  1.00 15.13 ? 13  LEU L CA  1 
ATOM   2390 C C   . LEU C 3 13  ? 4.024   4.860  21.631  1.00 18.03 ? 13  LEU L C   1 
ATOM   2391 O O   . LEU C 3 13  ? 3.628   5.960  22.019  1.00 17.08 ? 13  LEU L O   1 
ATOM   2392 C CB  . LEU C 3 13  ? 4.829   4.228  19.339  1.00 12.64 ? 13  LEU L CB  1 
ATOM   2393 C CG  . LEU C 3 13  ? 4.469   3.601  17.989  1.00 16.34 ? 13  LEU L CG  1 
ATOM   2394 C CD1 . LEU C 3 13  ? 5.577   3.803  16.947  1.00 15.35 ? 13  LEU L CD1 1 
ATOM   2395 C CD2 . LEU C 3 13  ? 4.162   2.115  18.193  1.00 17.29 ? 13  LEU L CD2 1 
ATOM   2396 N N   . SER C 3 14  ? 4.828   4.085  22.352  1.00 17.03 ? 14  SER L N   1 
ATOM   2397 C CA  . SER C 3 14  ? 5.388   4.472  23.640  1.00 18.30 ? 14  SER L CA  1 
ATOM   2398 C C   . SER C 3 14  ? 6.900   4.578  23.536  1.00 17.12 ? 14  SER L C   1 
ATOM   2399 O O   . SER C 3 14  ? 7.509   3.978  22.643  1.00 16.37 ? 14  SER L O   1 
ATOM   2400 C CB  . SER C 3 14  ? 5.026   3.451  24.730  1.00 19.01 ? 14  SER L CB  1 
ATOM   2401 O OG  . SER C 3 14  ? 3.630   3.324  24.853  1.00 22.89 ? 14  SER L OG  1 
ATOM   2402 N N   . PRO C 3 15  ? 7.545   5.343  24.420  1.00 16.56 ? 15  PRO L N   1 
ATOM   2403 C CA  . PRO C 3 15  ? 9.009   5.402  24.385  1.00 17.33 ? 15  PRO L CA  1 
ATOM   2404 C C   . PRO C 3 15  ? 9.606   4.005  24.486  1.00 17.77 ? 15  PRO L C   1 
ATOM   2405 O O   . PRO C 3 15  ? 9.071   3.116  25.160  1.00 17.23 ? 15  PRO L O   1 
ATOM   2406 C CB  . PRO C 3 15  ? 9.362   6.269  25.597  1.00 17.82 ? 15  PRO L CB  1 
ATOM   2407 C CG  . PRO C 3 15  ? 8.186   7.144  25.770  1.00 15.70 ? 15  PRO L CG  1 
ATOM   2408 C CD  . PRO C 3 15  ? 6.986   6.296  25.396  1.00 17.58 ? 15  PRO L CD  1 
ATOM   2409 N N   . GLY C 3 16  ? 10.696  3.798  23.757  1.00 16.14 ? 16  GLY L N   1 
ATOM   2410 C CA  . GLY C 3 16  ? 11.350  2.514  23.712  1.00 18.80 ? 16  GLY L CA  1 
ATOM   2411 C C   . GLY C 3 16  ? 10.876  1.599  22.611  1.00 15.81 ? 16  GLY L C   1 
ATOM   2412 O O   . GLY C 3 16  ? 11.552  0.608  22.327  1.00 17.51 ? 16  GLY L O   1 
ATOM   2413 N N   . GLU C 3 17  ? 9.743   1.898  21.985  1.00 15.13 ? 17  GLU L N   1 
ATOM   2414 C CA  . GLU C 3 17  ? 9.203   1.078  20.915  1.00 14.70 ? 17  GLU L CA  1 
ATOM   2415 C C   . GLU C 3 17  ? 9.700   1.573  19.562  1.00 16.17 ? 17  GLU L C   1 
ATOM   2416 O O   . GLU C 3 17  ? 10.231  2.675  19.432  1.00 14.04 ? 17  GLU L O   1 
ATOM   2417 C CB  . GLU C 3 17  ? 7.678   1.073  20.970  1.00 14.08 ? 17  GLU L CB  1 
ATOM   2418 C CG  . GLU C 3 17  ? 7.173   0.376  22.240  1.00 15.68 ? 17  GLU L CG  1 
ATOM   2419 C CD  . GLU C 3 17  ? 5.678   0.523  22.485  1.00 20.98 ? 17  GLU L CD  1 
ATOM   2420 O OE1 . GLU C 3 17  ? 4.963   1.180  21.675  1.00 17.16 ? 17  GLU L OE1 1 
ATOM   2421 O OE2 . GLU C 3 17  ? 5.213   -0.021 23.513  1.00 19.43 ? 17  GLU L OE2 1 
ATOM   2422 N N   . ARG C 3 18  ? 9.531   0.727  18.554  1.00 15.13 ? 18  ARG L N   1 
ATOM   2423 C CA  . ARG C 3 18  ? 10.022  0.992  17.209  1.00 15.42 ? 18  ARG L CA  1 
ATOM   2424 C C   . ARG C 3 18  ? 8.946   1.664  16.366  1.00 15.51 ? 18  ARG L C   1 
ATOM   2425 O O   . ARG C 3 18  ? 7.782   1.254  16.379  1.00 13.24 ? 18  ARG L O   1 
ATOM   2426 C CB  . ARG C 3 18  ? 10.475  -0.318 16.560  1.00 17.28 ? 18  ARG L CB  1 
ATOM   2427 C CG  . ARG C 3 18  ? 10.794  -0.252 15.065  1.00 21.30 ? 18  ARG L CG  1 
ATOM   2428 C CD  . ARG C 3 18  ? 11.391  -1.588 14.616  1.00 20.72 ? 18  ARG L CD  1 
ATOM   2429 N NE  . ARG C 3 18  ? 12.452  -1.966 15.545  1.00 26.78 ? 18  ARG L NE  1 
ATOM   2430 C CZ  . ARG C 3 18  ? 13.753  -1.851 15.308  1.00 29.08 ? 18  ARG L CZ  1 
ATOM   2431 N NH1 . ARG C 3 18  ? 14.214  -1.508 14.113  1.00 24.16 ? 18  ARG L NH1 1 
ATOM   2432 N NH2 . ARG C 3 18  ? 14.613  -2.085 16.298  1.00 23.24 ? 18  ARG L NH2 1 
ATOM   2433 N N   . ALA C 3 19  ? 9.345   2.714  15.643  1.00 16.12 ? 19  ALA L N   1 
ATOM   2434 C CA  . ALA C 3 19  ? 8.462   3.441  14.738  1.00 13.93 ? 19  ALA L CA  1 
ATOM   2435 C C   . ALA C 3 19  ? 8.888   3.142  13.311  1.00 12.28 ? 19  ALA L C   1 
ATOM   2436 O O   . ALA C 3 19  ? 10.067  3.285  12.976  1.00 15.04 ? 19  ALA L O   1 
ATOM   2437 C CB  . ALA C 3 19  ? 8.526   4.950  14.998  1.00 13.45 ? 19  ALA L CB  1 
ATOM   2438 N N   . THR C 3 20  ? 7.934   2.725  12.481  1.00 14.58 ? 20  THR L N   1 
ATOM   2439 C CA  . THR C 3 20  ? 8.152   2.505  11.055  1.00 15.36 ? 20  THR L CA  1 
ATOM   2440 C C   . THR C 3 20  ? 7.191   3.396  10.287  1.00 16.25 ? 20  THR L C   1 
ATOM   2441 O O   . THR C 3 20  ? 5.968   3.260  10.429  1.00 15.79 ? 20  THR L O   1 
ATOM   2442 C CB  . THR C 3 20  ? 7.930   1.040  10.666  1.00 16.13 ? 20  THR L CB  1 
ATOM   2443 O OG1 . THR C 3 20  ? 8.818   0.203  11.407  1.00 17.51 ? 20  THR L OG1 1 
ATOM   2444 C CG2 . THR C 3 20  ? 8.200   0.842  9.187   1.00 17.59 ? 20  THR L CG2 1 
ATOM   2445 N N   . LEU C 3 21  ? 7.734   4.301  9.474   1.00 12.41 ? 21  LEU L N   1 
ATOM   2446 C CA  . LEU C 3 21  ? 6.931   5.232  8.690   1.00 11.75 ? 21  LEU L CA  1 
ATOM   2447 C C   . LEU C 3 21  ? 7.164   4.968  7.210   1.00 12.96 ? 21  LEU L C   1 
ATOM   2448 O O   . LEU C 3 21  ? 8.302   4.752  6.787   1.00 13.79 ? 21  LEU L O   1 
ATOM   2449 C CB  . LEU C 3 21  ? 7.297   6.694  9.011   1.00 12.13 ? 21  LEU L CB  1 
ATOM   2450 C CG  . LEU C 3 21  ? 7.005   7.225  10.419  1.00 11.65 ? 21  LEU L CG  1 
ATOM   2451 C CD1 . LEU C 3 21  ? 7.932   6.612  11.459  1.00 11.67 ? 21  LEU L CD1 1 
ATOM   2452 C CD2 . LEU C 3 21  ? 7.142   8.737  10.434  1.00 9.52  ? 21  LEU L CD2 1 
ATOM   2453 N N   . SER C 3 22  ? 6.097   5.006  6.422   1.00 14.21 ? 22  SER L N   1 
ATOM   2454 C CA  . SER C 3 22  ? 6.185   4.714  5.003   1.00 13.86 ? 22  SER L CA  1 
ATOM   2455 C C   . SER C 3 22  ? 5.939   5.963  4.171   1.00 12.35 ? 22  SER L C   1 
ATOM   2456 O O   . SER C 3 22  ? 5.151   6.840  4.540   1.00 13.29 ? 22  SER L O   1 
ATOM   2457 C CB  . SER C 3 22  ? 5.182   3.636  4.604   1.00 17.87 ? 22  SER L CB  1 
ATOM   2458 O OG  . SER C 3 22  ? 5.433   2.465  5.367   1.00 21.77 ? 22  SER L OG  1 
ATOM   2459 N N   . CYS C 3 23  ? 6.624   6.014  3.032   1.00 12.76 ? 23  CYS L N   1 
ATOM   2460 C CA  . CYS C 3 23  ? 6.485   7.078  2.043   1.00 14.88 ? 23  CYS L CA  1 
ATOM   2461 C C   . CYS C 3 23  ? 6.591   6.452  0.663   1.00 14.97 ? 23  CYS L C   1 
ATOM   2462 O O   . CYS C 3 23  ? 7.583   5.779  0.369   1.00 18.12 ? 23  CYS L O   1 
ATOM   2463 C CB  . CYS C 3 23  ? 7.574   8.131  2.206   1.00 17.13 ? 23  CYS L CB  1 
ATOM   2464 S SG  . CYS C 3 23  ? 7.536   9.441  0.979   1.00 16.80 ? 23  CYS L SG  1 
ATOM   2465 N N   . ARG C 3 24  ? 5.586   6.663  -0.171  1.00 16.97 ? 24  ARG L N   1 
ATOM   2466 C CA  . ARG C 3 24  ? 5.563   6.112  -1.520  1.00 18.65 ? 24  ARG L CA  1 
ATOM   2467 C C   . ARG C 3 24  ? 5.533   7.249  -2.524  1.00 19.19 ? 24  ARG L C   1 
ATOM   2468 O O   . ARG C 3 24  ? 4.711   8.161  -2.399  1.00 19.55 ? 24  ARG L O   1 
ATOM   2469 C CB  . ARG C 3 24  ? 4.356   5.205  -1.734  1.00 22.97 ? 24  ARG L CB  1 
ATOM   2470 C CG  . ARG C 3 24  ? 4.701   3.728  -1.666  1.00 34.49 ? 24  ARG L CG  1 
ATOM   2471 C CD  . ARG C 3 24  ? 4.225   3.090  -0.363  1.00 35.81 ? 24  ARG L CD  1 
ATOM   2472 N NE  . ARG C 3 24  ? 4.598   1.679  -0.292  1.00 46.11 ? 24  ARG L NE  1 
ATOM   2473 C CZ  . ARG C 3 24  ? 4.052   0.713  -1.022  1.00 45.94 ? 24  ARG L CZ  1 
ATOM   2474 N NH1 . ARG C 3 24  ? 3.109   0.969  -1.918  1.00 44.74 ? 24  ARG L NH1 1 
ATOM   2475 N NH2 . ARG C 3 24  ? 4.477   -0.540 -0.862  1.00 48.78 ? 24  ARG L NH2 1 
ATOM   2476 N N   . GLN C 3 25  ? 6.414   7.205  -3.517  1.00 19.58 ? 25  GLN L N   1 
ATOM   2477 C CA  . GLN C 3 25  ? 6.385   8.255  -4.520  1.00 16.50 ? 25  GLN L CA  1 
ATOM   2478 C C   . GLN C 3 25  ? 5.800   7.728  -5.819  1.00 19.06 ? 25  GLN L C   1 
ATOM   2479 O O   . GLN C 3 25  ? 5.816   6.524  -6.092  1.00 20.41 ? 25  GLN L O   1 
ATOM   2480 C CB  . GLN C 3 25  ? 7.768   8.882  -4.737  1.00 21.84 ? 25  GLN L CB  1 
ATOM   2481 C CG  . GLN C 3 25  ? 8.833   8.119  -5.405  1.00 24.72 ? 25  GLN L CG  1 
ATOM   2482 C CD  . GLN C 3 25  ? 10.119  8.940  -5.449  1.00 21.92 ? 25  GLN L CD  1 
ATOM   2483 O OE1 . GLN C 3 25  ? 10.256  9.945  -4.741  1.00 20.60 ? 25  GLN L OE1 1 
ATOM   2484 N NE2 . GLN C 3 25  ? 11.058  8.522  -6.285  1.00 24.96 ? 25  GLN L NE2 1 
ATOM   2485 N N   . SER C 3 26  ? 5.248   8.657  -6.604  1.00 20.37 ? 26  SER L N   1 
ATOM   2486 C CA  . SER C 3 26  ? 4.411   8.294  -7.744  1.00 20.51 ? 26  SER L CA  1 
ATOM   2487 C C   . SER C 3 26  ? 5.207   7.751  -8.928  1.00 24.31 ? 26  SER L C   1 
ATOM   2488 O O   . SER C 3 26  ? 4.610   7.121  -9.810  1.00 25.96 ? 26  SER L O   1 
ATOM   2489 C CB  . SER C 3 26  ? 3.562   9.502  -8.165  1.00 19.91 ? 26  SER L CB  1 
ATOM   2490 O OG  . SER C 3 26  ? 4.362   10.617 -8.536  1.00 19.84 ? 26  SER L OG  1 
ATOM   2491 N N   . GLN C 3 27  ? 6.526   7.953  -8.962  1.00 23.40 ? 27  GLN L N   1 
ATOM   2492 C CA  . GLN C 3 27  ? 7.372   7.443  -10.038 1.00 28.57 ? 27  GLN L CA  1 
ATOM   2493 C C   . GLN C 3 27  ? 8.794   7.305  -9.510  1.00 26.99 ? 27  GLN L C   1 
ATOM   2494 O O   . GLN C 3 27  ? 9.207   8.053  -8.618  1.00 27.74 ? 27  GLN L O   1 
ATOM   2495 C CB  . GLN C 3 27  ? 7.345   8.367  -11.271 1.00 29.99 ? 27  GLN L CB  1 
ATOM   2496 C CG  . GLN C 3 27  ? 7.888   9.785  -11.012 1.00 29.17 ? 27  GLN L CG  1 
ATOM   2497 C CD  . GLN C 3 27  ? 7.790   10.725 -12.225 1.00 35.16 ? 27  GLN L CD  1 
ATOM   2498 O OE1 . GLN C 3 27  ? 8.725   10.825 -13.024 1.00 36.76 ? 27  GLN L OE1 1 
ATOM   2499 N NE2 . GLN C 3 27  ? 6.667   11.435 -12.344 1.00 30.81 ? 27  GLN L NE2 1 
ATOM   2500 N N   . SER C 3 28  ? 9.531   6.336  -10.056 1.00 24.01 ? 28  SER L N   1 
ATOM   2501 C CA  . SER C 3 28  ? 10.945  6.195  -9.738  1.00 22.65 ? 28  SER L CA  1 
ATOM   2502 C C   . SER C 3 28  ? 11.781  7.137  -10.597 1.00 25.47 ? 28  SER L C   1 
ATOM   2503 O O   . SER C 3 28  ? 11.408  7.511  -11.714 1.00 22.45 ? 28  SER L O   1 
ATOM   2504 C CB  . SER C 3 28  ? 11.432  4.759  -9.943  1.00 21.72 ? 28  SER L CB  1 
ATOM   2505 O OG  . SER C 3 28  ? 10.382  3.952  -10.394 1.00 30.09 ? 28  SER L OG  1 
ATOM   2506 N N   . VAL C 3 29  ? 12.944  7.497  -10.057 1.00 24.33 ? 29  VAL L N   1 
ATOM   2507 C CA  . VAL C 3 29  ? 13.814  8.531  -10.598 1.00 23.94 ? 29  VAL L CA  1 
ATOM   2508 C C   . VAL C 3 29  ? 15.131  7.970  -11.109 1.00 25.46 ? 29  VAL L C   1 
ATOM   2509 O O   . VAL C 3 29  ? 15.939  8.724  -11.680 1.00 26.42 ? 29  VAL L O   1 
ATOM   2510 C CB  . VAL C 3 29  ? 14.061  9.616  -9.531  1.00 23.07 ? 29  VAL L CB  1 
ATOM   2511 C CG1 . VAL C 3 29  ? 14.763  10.797 -10.106 1.00 30.34 ? 29  VAL L CG1 1 
ATOM   2512 C CG2 . VAL C 3 29  ? 12.738  10.038 -8.922  1.00 32.17 ? 29  VAL L CG2 1 
ATOM   2513 N N   . GLY C 3 30  ? 15.372  6.669  -10.948 1.00 21.34 ? 30  GLY L N   1 
ATOM   2514 C CA  . GLY C 3 30  ? 16.677  6.107  -11.216 1.00 24.01 ? 30  GLY L CA  1 
ATOM   2515 C C   . GLY C 3 30  ? 17.661  6.217  -10.072 1.00 23.87 ? 30  GLY L C   1 
ATOM   2516 O O   . GLY C 3 30  ? 18.756  5.646  -10.163 1.00 25.18 ? 30  GLY L O   1 
ATOM   2517 N N   . TRP C 3 31  ? 17.326  6.958  -9.018  1.00 18.69 ? 31  TRP L N   1 
ATOM   2518 C CA  . TRP C 3 31  ? 18.083  7.000  -7.768  1.00 19.82 ? 31  TRP L CA  1 
ATOM   2519 C C   . TRP C 3 31  ? 17.110  7.470  -6.691  1.00 16.75 ? 31  TRP L C   1 
ATOM   2520 O O   . TRP C 3 31  ? 15.906  7.565  -6.937  1.00 18.02 ? 31  TRP L O   1 
ATOM   2521 C CB  . TRP C 3 31  ? 19.331  7.885  -7.879  1.00 20.31 ? 31  TRP L CB  1 
ATOM   2522 C CG  . TRP C 3 31  ? 19.085  9.366  -8.070  1.00 19.06 ? 31  TRP L CG  1 
ATOM   2523 C CD1 . TRP C 3 31  ? 18.420  9.964  -9.096  1.00 20.74 ? 31  TRP L CD1 1 
ATOM   2524 C CD2 . TRP C 3 31  ? 19.558  10.425 -7.229  1.00 19.99 ? 31  TRP L CD2 1 
ATOM   2525 N NE1 . TRP C 3 31  ? 18.430  11.327 -8.937  1.00 18.45 ? 31  TRP L NE1 1 
ATOM   2526 C CE2 . TRP C 3 31  ? 19.126  11.638 -7.802  1.00 19.86 ? 31  TRP L CE2 1 
ATOM   2527 C CE3 . TRP C 3 31  ? 20.289  10.464 -6.038  1.00 17.27 ? 31  TRP L CE3 1 
ATOM   2528 C CZ2 . TRP C 3 31  ? 19.399  12.879 -7.222  1.00 17.52 ? 31  TRP L CZ2 1 
ATOM   2529 C CZ3 . TRP C 3 31  ? 20.572  11.698 -5.472  1.00 19.53 ? 31  TRP L CZ3 1 
ATOM   2530 C CH2 . TRP C 3 31  ? 20.130  12.888 -6.068  1.00 15.83 ? 31  TRP L CH2 1 
ATOM   2531 N N   . SER C 3 32  ? 17.618  7.788  -5.502  1.00 16.82 ? 32  SER L N   1 
ATOM   2532 C CA  . SER C 3 32  ? 16.755  8.042  -4.348  1.00 16.50 ? 32  SER L CA  1 
ATOM   2533 C C   . SER C 3 32  ? 17.006  9.409  -3.722  1.00 14.06 ? 32  SER L C   1 
ATOM   2534 O O   . SER C 3 32  ? 17.481  9.499  -2.582  1.00 15.22 ? 32  SER L O   1 
ATOM   2535 C CB  . SER C 3 32  ? 16.926  6.937  -3.313  1.00 17.99 ? 32  SER L CB  1 
ATOM   2536 O OG  . SER C 3 32  ? 16.595  5.689  -3.893  1.00 19.10 ? 32  SER L OG  1 
ATOM   2537 N N   . PRO C 3 33  ? 16.661  10.502 -4.420  1.00 15.31 ? 33  PRO L N   1 
ATOM   2538 C CA  . PRO C 3 33  ? 16.713  11.825 -3.771  1.00 13.35 ? 33  PRO L CA  1 
ATOM   2539 C C   . PRO C 3 33  ? 15.477  11.988 -2.891  1.00 14.16 ? 33  PRO L C   1 
ATOM   2540 O O   . PRO C 3 33  ? 14.497  12.665 -3.211  1.00 12.44 ? 33  PRO L O   1 
ATOM   2541 C CB  . PRO C 3 33  ? 16.721  12.786 -4.960  1.00 14.87 ? 33  PRO L CB  1 
ATOM   2542 C CG  . PRO C 3 33  ? 15.920  12.078 -5.993  1.00 14.51 ? 33  PRO L CG  1 
ATOM   2543 C CD  . PRO C 3 33  ? 16.196  10.597 -5.815  1.00 16.75 ? 33  PRO L CD  1 
ATOM   2544 N N   . LEU C 3 34  ? 15.512  11.307 -1.752  1.00 13.68 ? 34  LEU L N   1 
ATOM   2545 C CA  . LEU C 3 34  ? 14.368  11.205 -0.860  1.00 12.53 ? 34  LEU L CA  1 
ATOM   2546 C C   . LEU C 3 34  ? 14.857  11.556 0.536   1.00 11.84 ? 34  LEU L C   1 
ATOM   2547 O O   . LEU C 3 34  ? 15.807  10.945 1.037   1.00 13.73 ? 34  LEU L O   1 
ATOM   2548 C CB  . LEU C 3 34  ? 13.733  9.816  -0.900  1.00 14.36 ? 34  LEU L CB  1 
ATOM   2549 C CG  . LEU C 3 34  ? 12.411  9.988  -0.158  1.00 18.73 ? 34  LEU L CG  1 
ATOM   2550 C CD1 . LEU C 3 34  ? 11.230  9.644  -0.999  1.00 18.58 ? 34  LEU L CD1 1 
ATOM   2551 C CD2 . LEU C 3 34  ? 12.447  9.259  1.185   1.00 13.87 ? 34  LEU L CD2 1 
ATOM   2552 N N   . ALA C 3 35  ? 14.230  12.557 1.142   1.00 11.78 ? 35  ALA L N   1 
ATOM   2553 C CA  . ALA C 3 35  ? 14.616  13.045 2.452   1.00 10.13 ? 35  ALA L CA  1 
ATOM   2554 C C   . ALA C 3 35  ? 13.458  12.890 3.421   1.00 10.18 ? 35  ALA L C   1 
ATOM   2555 O O   . ALA C 3 35  ? 12.290  12.852 3.020   1.00 11.68 ? 35  ALA L O   1 
ATOM   2556 C CB  . ALA C 3 35  ? 15.043  14.514 2.397   1.00 10.13 ? 35  ALA L CB  1 
ATOM   2557 N N   . TRP C 3 36  ? 13.803  12.824 4.710   1.00 10.66 ? 36  TRP L N   1 
ATOM   2558 C CA  . TRP C 3 36  ? 12.848  12.804 5.807   1.00 10.35 ? 36  TRP L CA  1 
ATOM   2559 C C   . TRP C 3 36  ? 13.123  13.981 6.726   1.00 9.11  ? 36  TRP L C   1 
ATOM   2560 O O   . TRP C 3 36  ? 14.284  14.241 7.076   1.00 11.90 ? 36  TRP L O   1 
ATOM   2561 C CB  . TRP C 3 36  ? 12.952  11.504 6.626   1.00 11.57 ? 36  TRP L CB  1 
ATOM   2562 C CG  . TRP C 3 36  ? 12.510  10.288 5.905   1.00 11.02 ? 36  TRP L CG  1 
ATOM   2563 C CD1 . TRP C 3 36  ? 13.277  9.468  5.142   1.00 11.32 ? 36  TRP L CD1 1 
ATOM   2564 C CD2 . TRP C 3 36  ? 11.180  9.772  5.850   1.00 12.69 ? 36  TRP L CD2 1 
ATOM   2565 N NE1 . TRP C 3 36  ? 12.512  8.447  4.642   1.00 12.32 ? 36  TRP L NE1 1 
ATOM   2566 C CE2 . TRP C 3 36  ? 11.218  8.616  5.050   1.00 11.55 ? 36  TRP L CE2 1 
ATOM   2567 C CE3 . TRP C 3 36  ? 9.959   10.163 6.423   1.00 10.59 ? 36  TRP L CE3 1 
ATOM   2568 C CZ2 . TRP C 3 36  ? 10.081  7.838  4.802   1.00 11.60 ? 36  TRP L CZ2 1 
ATOM   2569 C CZ3 . TRP C 3 36  ? 8.822   9.389  6.176   1.00 11.30 ? 36  TRP L CZ3 1 
ATOM   2570 C CH2 . TRP C 3 36  ? 8.896   8.239  5.369   1.00 13.44 ? 36  TRP L CH2 1 
ATOM   2571 N N   . TYR C 3 37  ? 12.059  14.667 7.133   1.00 11.14 ? 37  TYR L N   1 
ATOM   2572 C CA  . TYR C 3 37  ? 12.130  15.804 8.038   1.00 12.64 ? 37  TYR L CA  1 
ATOM   2573 C C   . TYR C 3 37  ? 11.298  15.534 9.281   1.00 11.47 ? 37  TYR L C   1 
ATOM   2574 O O   . TYR C 3 37  ? 10.240  14.897 9.206   1.00 13.16 ? 37  TYR L O   1 
ATOM   2575 C CB  . TYR C 3 37  ? 11.631  17.092 7.354   1.00 10.11 ? 37  TYR L CB  1 
ATOM   2576 C CG  . TYR C 3 37  ? 12.422  17.403 6.125   1.00 11.13 ? 37  TYR L CG  1 
ATOM   2577 C CD1 . TYR C 3 37  ? 12.071  16.855 4.896   1.00 10.30 ? 37  TYR L CD1 1 
ATOM   2578 C CD2 . TYR C 3 37  ? 13.535  18.233 6.190   1.00 10.11 ? 37  TYR L CD2 1 
ATOM   2579 C CE1 . TYR C 3 37  ? 12.831  17.110 3.772   1.00 11.13 ? 37  TYR L CE1 1 
ATOM   2580 C CE2 . TYR C 3 37  ? 14.290  18.497 5.071   1.00 11.28 ? 37  TYR L CE2 1 
ATOM   2581 C CZ  . TYR C 3 37  ? 13.926  17.930 3.864   1.00 11.93 ? 37  TYR L CZ  1 
ATOM   2582 O OH  . TYR C 3 37  ? 14.676  18.188 2.742   1.00 12.56 ? 37  TYR L OH  1 
ATOM   2583 N N   . GLN C 3 38  ? 11.786  16.007 10.425  1.00 10.00 ? 38  GLN L N   1 
ATOM   2584 C CA  . GLN C 3 38  ? 11.024  16.023 11.669  1.00 10.61 ? 38  GLN L CA  1 
ATOM   2585 C C   . GLN C 3 38  ? 10.519  17.435 11.945  1.00 9.40  ? 38  GLN L C   1 
ATOM   2586 O O   . GLN C 3 38  ? 11.229  18.409 11.689  1.00 12.47 ? 38  GLN L O   1 
ATOM   2587 C CB  . GLN C 3 38  ? 11.908  15.547 12.825  1.00 10.70 ? 38  GLN L CB  1 
ATOM   2588 C CG  . GLN C 3 38  ? 11.249  15.562 14.189  1.00 12.97 ? 38  GLN L CG  1 
ATOM   2589 C CD  . GLN C 3 38  ? 12.255  15.325 15.293  1.00 17.27 ? 38  GLN L CD  1 
ATOM   2590 O OE1 . GLN C 3 38  ? 13.153  16.139 15.503  1.00 17.89 ? 38  GLN L OE1 1 
ATOM   2591 N NE2 . GLN C 3 38  ? 12.128  14.196 15.992  1.00 16.23 ? 38  GLN L NE2 1 
ATOM   2592 N N   . GLN C 3 39  ? 9.290   17.554 12.456  1.00 11.28 ? 39  GLN L N   1 
ATOM   2593 C CA  . GLN C 3 39  ? 8.769   18.849 12.889  1.00 13.36 ? 39  GLN L CA  1 
ATOM   2594 C C   . GLN C 3 39  ? 8.086   18.718 14.242  1.00 14.59 ? 39  GLN L C   1 
ATOM   2595 O O   . GLN C 3 39  ? 7.039   18.064 14.355  1.00 12.82 ? 39  GLN L O   1 
ATOM   2596 C CB  . GLN C 3 39  ? 7.780   19.451 11.879  1.00 10.14 ? 39  GLN L CB  1 
ATOM   2597 C CG  . GLN C 3 39  ? 7.446   20.910 12.222  1.00 13.53 ? 39  GLN L CG  1 
ATOM   2598 C CD  . GLN C 3 39  ? 6.580   21.592 11.191  1.00 15.13 ? 39  GLN L CD  1 
ATOM   2599 O OE1 . GLN C 3 39  ? 5.728   20.966 10.571  1.00 15.66 ? 39  GLN L OE1 1 
ATOM   2600 N NE2 . GLN C 3 39  ? 6.794   22.898 11.006  1.00 14.89 ? 39  GLN L NE2 1 
ATOM   2601 N N   . LYS C 3 40  ? 8.669   19.366 15.266  1.00 17.66 ? 40  LYS L N   1 
ATOM   2602 C CA  . LYS C 3 40  ? 8.058   19.463 16.583  1.00 21.39 ? 40  LYS L CA  1 
ATOM   2603 C C   . LYS C 3 40  ? 7.146   20.683 16.650  1.00 21.66 ? 40  LYS L C   1 
ATOM   2604 O O   . LYS C 3 40  ? 7.360   21.671 15.930  1.00 22.65 ? 40  LYS L O   1 
ATOM   2605 C CB  . LYS C 3 40  ? 9.139   19.545 17.659  1.00 22.16 ? 40  LYS L CB  1 
ATOM   2606 C CG  . LYS C 3 40  ? 10.177  18.429 17.580  1.00 23.36 ? 40  LYS L CG  1 
ATOM   2607 C CD  . LYS C 3 40  ? 11.236  18.579 18.671  1.00 28.60 ? 40  LYS L CD  1 
ATOM   2608 C CE  . LYS C 3 40  ? 12.293  17.487 18.569  1.00 27.73 ? 40  LYS L CE  1 
ATOM   2609 N NZ  . LYS C 3 40  ? 13.481  17.756 19.444  1.00 32.36 ? 40  LYS L NZ  1 
ATOM   2610 N N   . PRO C 3 41  ? 6.095   20.651 17.469  1.00 27.40 ? 41  PRO L N   1 
ATOM   2611 C CA  . PRO C 3 41  ? 5.120   21.752 17.449  1.00 26.95 ? 41  PRO L CA  1 
ATOM   2612 C C   . PRO C 3 41  ? 5.768   23.110 17.693  1.00 27.18 ? 41  PRO L C   1 
ATOM   2613 O O   . PRO C 3 41  ? 6.618   23.268 18.568  1.00 28.43 ? 41  PRO L O   1 
ATOM   2614 C CB  . PRO C 3 41  ? 4.136   21.377 18.568  1.00 29.67 ? 41  PRO L CB  1 
ATOM   2615 C CG  . PRO C 3 41  ? 4.811   20.267 19.351  1.00 27.90 ? 41  PRO L CG  1 
ATOM   2616 C CD  . PRO C 3 41  ? 5.702   19.566 18.387  1.00 28.70 ? 41  PRO L CD  1 
ATOM   2617 N N   . GLY C 3 42  ? 5.384   24.087 16.873  1.00 27.23 ? 42  GLY L N   1 
ATOM   2618 C CA  . GLY C 3 42  ? 5.899   25.438 16.999  1.00 26.65 ? 42  GLY L CA  1 
ATOM   2619 C C   . GLY C 3 42  ? 7.338   25.621 16.576  1.00 26.78 ? 42  GLY L C   1 
ATOM   2620 O O   . GLY C 3 42  ? 7.935   26.661 16.867  1.00 30.44 ? 42  GLY L O   1 
ATOM   2621 N N   . GLN C 3 43  ? 7.912   24.646 15.882  1.00 23.15 ? 43  GLN L N   1 
ATOM   2622 C CA  . GLN C 3 43  ? 9.323   24.630 15.541  1.00 22.00 ? 43  GLN L CA  1 
ATOM   2623 C C   . GLN C 3 43  ? 9.443   24.346 14.048  1.00 22.27 ? 43  GLN L C   1 
ATOM   2624 O O   . GLN C 3 43  ? 8.534   23.764 13.453  1.00 18.80 ? 43  GLN L O   1 
ATOM   2625 C CB  . GLN C 3 43  ? 10.023  23.575 16.410  1.00 21.17 ? 43  GLN L CB  1 
ATOM   2626 C CG  . GLN C 3 43  ? 11.467  23.285 16.148  1.00 31.46 ? 43  GLN L CG  1 
ATOM   2627 C CD  . GLN C 3 43  ? 12.075  22.472 17.287  1.00 30.64 ? 43  GLN L CD  1 
ATOM   2628 O OE1 . GLN C 3 43  ? 11.757  22.702 18.459  1.00 32.32 ? 43  GLN L OE1 1 
ATOM   2629 N NE2 . GLN C 3 43  ? 12.936  21.510 16.948  1.00 38.17 ? 43  GLN L NE2 1 
ATOM   2630 N N   . ALA C 3 44  ? 10.539  24.804 13.429  1.00 17.57 ? 44  ALA L N   1 
ATOM   2631 C CA  . ALA C 3 44  ? 10.719  24.575 12.003  1.00 18.20 ? 44  ALA L CA  1 
ATOM   2632 C C   . ALA C 3 44  ? 11.079  23.117 11.731  1.00 13.80 ? 44  ALA L C   1 
ATOM   2633 O O   . ALA C 3 44  ? 11.559  22.414 12.624  1.00 15.56 ? 44  ALA L O   1 
ATOM   2634 C CB  . ALA C 3 44  ? 11.811  25.489 11.462  1.00 19.13 ? 44  ALA L CB  1 
ATOM   2635 N N   . PRO C 3 45  ? 10.867  22.639 10.497  1.00 15.10 ? 45  PRO L N   1 
ATOM   2636 C CA  . PRO C 3 45  ? 11.340  21.301 10.135  1.00 12.85 ? 45  PRO L CA  1 
ATOM   2637 C C   . PRO C 3 45  ? 12.855  21.174 10.262  1.00 16.04 ? 45  PRO L C   1 
ATOM   2638 O O   . PRO C 3 45  ? 13.608  22.154 10.195  1.00 14.62 ? 45  PRO L O   1 
ATOM   2639 C CB  . PRO C 3 45  ? 10.892  21.145 8.671   1.00 12.33 ? 45  PRO L CB  1 
ATOM   2640 C CG  . PRO C 3 45  ? 9.751   22.137 8.515   1.00 14.40 ? 45  PRO L CG  1 
ATOM   2641 C CD  . PRO C 3 45  ? 10.203  23.298 9.357   1.00 14.23 ? 45  PRO L CD  1 
ATOM   2642 N N   . ARG C 3 46  ? 13.291  19.928 10.452  1.00 12.25 ? 46  ARG L N   1 
ATOM   2643 C CA  . ARG C 3 46  ? 14.688  19.578 10.662  1.00 13.87 ? 46  ARG L CA  1 
ATOM   2644 C C   . ARG C 3 46  ? 15.006  18.350 9.823   1.00 12.29 ? 46  ARG L C   1 
ATOM   2645 O O   . ARG C 3 46  ? 14.325  17.325 9.949   1.00 13.19 ? 46  ARG L O   1 
ATOM   2646 C CB  . ARG C 3 46  ? 14.909  19.304 12.156  1.00 17.44 ? 46  ARG L CB  1 
ATOM   2647 C CG  . ARG C 3 46  ? 16.123  18.538 12.553  1.00 21.17 ? 46  ARG L CG  1 
ATOM   2648 C CD  . ARG C 3 46  ? 16.256  18.662 14.067  1.00 26.55 ? 46  ARG L CD  1 
ATOM   2649 N NE  . ARG C 3 46  ? 15.770  17.484 14.775  1.00 27.95 ? 46  ARG L NE  1 
ATOM   2650 C CZ  . ARG C 3 46  ? 16.570  16.601 15.359  1.00 30.28 ? 46  ARG L CZ  1 
ATOM   2651 N NH1 . ARG C 3 46  ? 17.885  16.744 15.333  1.00 27.59 ? 46  ARG L NH1 1 
ATOM   2652 N NH2 . ARG C 3 46  ? 16.039  15.558 15.988  1.00 24.98 ? 46  ARG L NH2 1 
ATOM   2653 N N   . LEU C 3 47  ? 16.040  18.439 8.988   1.00 11.71 ? 47  LEU L N   1 
ATOM   2654 C CA  . LEU C 3 47  ? 16.430  17.317 8.144   1.00 10.86 ? 47  LEU L CA  1 
ATOM   2655 C C   . LEU C 3 47  ? 16.982  16.170 8.983   1.00 12.25 ? 47  LEU L C   1 
ATOM   2656 O O   . LEU C 3 47  ? 17.891  16.371 9.801   1.00 14.12 ? 47  LEU L O   1 
ATOM   2657 C CB  . LEU C 3 47  ? 17.484  17.769 7.129   1.00 10.59 ? 47  LEU L CB  1 
ATOM   2658 C CG  . LEU C 3 47  ? 18.060  16.670 6.227   1.00 11.50 ? 47  LEU L CG  1 
ATOM   2659 C CD1 . LEU C 3 47  ? 16.952  16.054 5.348   1.00 11.44 ? 47  LEU L CD1 1 
ATOM   2660 C CD2 . LEU C 3 47  ? 19.218  17.183 5.366   1.00 10.46 ? 47  LEU L CD2 1 
ATOM   2661 N N   . LEU C 3 48  ? 16.448  14.967 8.761   1.00 10.47 ? 48  LEU L N   1 
ATOM   2662 C CA  . LEU C 3 48  ? 16.899  13.739 9.406   1.00 12.90 ? 48  LEU L CA  1 
ATOM   2663 C C   . LEU C 3 48  ? 17.731  12.858 8.491   1.00 11.82 ? 48  LEU L C   1 
ATOM   2664 O O   . LEU C 3 48  ? 18.837  12.441 8.852   1.00 15.13 ? 48  LEU L O   1 
ATOM   2665 C CB  . LEU C 3 48  ? 15.693  12.927 9.895   1.00 12.07 ? 48  LEU L CB  1 
ATOM   2666 C CG  . LEU C 3 48  ? 14.823  13.528 10.988  1.00 12.95 ? 48  LEU L CG  1 
ATOM   2667 C CD1 . LEU C 3 48  ? 13.601  12.636 11.236  1.00 11.31 ? 48  LEU L CD1 1 
ATOM   2668 C CD2 . LEU C 3 48  ? 15.648  13.701 12.249  1.00 14.90 ? 48  LEU L CD2 1 
ATOM   2669 N N   . ILE C 3 49  ? 17.193  12.532 7.322   1.00 10.72 ? 49  ILE L N   1 
ATOM   2670 C CA  . ILE C 3 49  ? 17.758  11.535 6.427   1.00 11.93 ? 49  ILE L CA  1 
ATOM   2671 C C   . ILE C 3 49  ? 17.708  12.117 5.023   1.00 12.62 ? 49  ILE L C   1 
ATOM   2672 O O   . ILE C 3 49  ? 16.741  12.793 4.664   1.00 13.39 ? 49  ILE L O   1 
ATOM   2673 C CB  . ILE C 3 49  ? 16.950  10.218 6.486   1.00 14.62 ? 49  ILE L CB  1 
ATOM   2674 C CG1 . ILE C 3 49  ? 16.986  9.603  7.895   1.00 14.51 ? 49  ILE L CG1 1 
ATOM   2675 C CG2 . ILE C 3 49  ? 17.439  9.243  5.430   1.00 17.10 ? 49  ILE L CG2 1 
ATOM   2676 C CD1 . ILE C 3 49  ? 18.321  9.032  8.262   1.00 15.86 ? 49  ILE L CD1 1 
ATOM   2677 N N   . TYR C 3 50  ? 18.734  11.856 4.221   1.00 13.17 ? 50  TYR L N   1 
ATOM   2678 C CA  . TYR C 3 50  ? 18.668  12.171 2.800   1.00 13.10 ? 50  TYR L CA  1 
ATOM   2679 C C   . TYR C 3 50  ? 19.240  11.000 2.013   1.00 14.37 ? 50  TYR L C   1 
ATOM   2680 O O   . TYR C 3 50  ? 19.855  10.082 2.570   1.00 15.73 ? 50  TYR L O   1 
ATOM   2681 C CB  . TYR C 3 50  ? 19.417  13.469 2.480   1.00 10.64 ? 50  TYR L CB  1 
ATOM   2682 C CG  . TYR C 3 50  ? 20.897  13.331 2.704   1.00 13.89 ? 50  TYR L CG  1 
ATOM   2683 C CD1 . TYR C 3 50  ? 21.445  13.494 3.971   1.00 12.63 ? 50  TYR L CD1 1 
ATOM   2684 C CD2 . TYR C 3 50  ? 21.739  12.989 1.665   1.00 14.45 ? 50  TYR L CD2 1 
ATOM   2685 C CE1 . TYR C 3 50  ? 22.801  13.348 4.187   1.00 17.77 ? 50  TYR L CE1 1 
ATOM   2686 C CE2 . TYR C 3 50  ? 23.103  12.825 1.873   1.00 15.38 ? 50  TYR L CE2 1 
ATOM   2687 C CZ  . TYR C 3 50  ? 23.618  13.012 3.131   1.00 18.58 ? 50  TYR L CZ  1 
ATOM   2688 O OH  . TYR C 3 50  ? 24.963  12.863 3.337   1.00 22.71 ? 50  TYR L OH  1 
ATOM   2689 N N   . GLY C 3 51  ? 19.032  11.028 0.699   1.00 14.01 ? 51  GLY L N   1 
ATOM   2690 C CA  . GLY C 3 51  ? 19.493  9.929  -0.128  1.00 14.40 ? 51  GLY L CA  1 
ATOM   2691 C C   . GLY C 3 51  ? 18.925  8.601  0.307   1.00 16.66 ? 51  GLY L C   1 
ATOM   2692 O O   . GLY C 3 51  ? 19.613  7.588  0.214   1.00 19.41 ? 51  GLY L O   1 
ATOM   2693 N N   . ALA C 3 52  ? 17.687  8.598  0.812   1.00 15.89 ? 52  ALA L N   1 
ATOM   2694 C CA  . ALA C 3 52  ? 16.984  7.445  1.380   1.00 16.77 ? 52  ALA L CA  1 
ATOM   2695 C C   . ALA C 3 52  ? 17.565  6.930  2.699   1.00 17.13 ? 52  ALA L C   1 
ATOM   2696 O O   . ALA C 3 52  ? 16.797  6.564  3.590   1.00 18.18 ? 52  ALA L O   1 
ATOM   2697 C CB  . ALA C 3 52  ? 16.908  6.297  0.362   1.00 16.82 ? 52  ALA L CB  1 
ATOM   2698 N N   . PHE C 3 53  ? 18.894  6.870  2.862   1.00 17.44 ? 53  PHE L N   1 
ATOM   2699 C CA  . PHE C 3 53  ? 19.458  6.204  4.039   1.00 18.47 ? 53  PHE L CA  1 
ATOM   2700 C C   . PHE C 3 53  ? 20.560  6.963  4.771   1.00 18.51 ? 53  PHE L C   1 
ATOM   2701 O O   . PHE C 3 53  ? 21.049  6.468  5.795   1.00 18.20 ? 53  PHE L O   1 
ATOM   2702 C CB  . PHE C 3 53  ? 20.000  4.814  3.655   1.00 19.61 ? 53  PHE L CB  1 
ATOM   2703 C CG  . PHE C 3 53  ? 21.087  4.859  2.620   1.00 21.06 ? 53  PHE L CG  1 
ATOM   2704 C CD1 . PHE C 3 53  ? 20.784  4.704  1.280   1.00 21.75 ? 53  PHE L CD1 1 
ATOM   2705 C CD2 . PHE C 3 53  ? 22.407  5.082  2.983   1.00 20.30 ? 53  PHE L CD2 1 
ATOM   2706 C CE1 . PHE C 3 53  ? 21.786  4.758  0.315   1.00 27.43 ? 53  PHE L CE1 1 
ATOM   2707 C CE2 . PHE C 3 53  ? 23.412  5.143  2.028   1.00 20.96 ? 53  PHE L CE2 1 
ATOM   2708 C CZ  . PHE C 3 53  ? 23.096  4.976  0.691   1.00 20.08 ? 53  PHE L CZ  1 
ATOM   2709 N N   . SER C 3 54  ? 20.974  8.128  4.291   1.00 15.64 ? 54  SER L N   1 
ATOM   2710 C CA  . SER C 3 54  ? 22.104  8.834  4.870   1.00 15.11 ? 54  SER L CA  1 
ATOM   2711 C C   . SER C 3 54  ? 21.628  9.773  5.969   1.00 16.15 ? 54  SER L C   1 
ATOM   2712 O O   . SER C 3 54  ? 20.665  10.519 5.777   1.00 16.09 ? 54  SER L O   1 
ATOM   2713 C CB  . SER C 3 54  ? 22.849  9.616  3.792   1.00 17.26 ? 54  SER L CB  1 
ATOM   2714 O OG  . SER C 3 54  ? 23.402  8.717  2.859   1.00 19.62 ? 54  SER L OG  1 
ATOM   2715 N N   . ARG C 3 55  ? 22.302  9.727  7.120   1.00 15.75 ? 55  ARG L N   1 
ATOM   2716 C CA  . ARG C 3 55  ? 21.939  10.569 8.260   1.00 15.21 ? 55  ARG L CA  1 
ATOM   2717 C C   . ARG C 3 55  ? 22.504  11.975 8.097   1.00 17.54 ? 55  ARG L C   1 
ATOM   2718 O O   . ARG C 3 55  ? 23.693  12.144 7.805   1.00 19.19 ? 55  ARG L O   1 
ATOM   2719 C CB  . ARG C 3 55  ? 22.468  9.968  9.561   1.00 20.28 ? 55  ARG L CB  1 
ATOM   2720 C CG  . ARG C 3 55  ? 21.474  9.163  10.349  1.00 21.66 ? 55  ARG L CG  1 
ATOM   2721 C CD  . ARG C 3 55  ? 22.121  8.525  11.571  1.00 25.43 ? 55  ARG L CD  1 
ATOM   2722 N NE  . ARG C 3 55  ? 21.530  7.210  11.804  1.00 29.34 ? 55  ARG L NE  1 
ATOM   2723 C CZ  . ARG C 3 55  ? 21.950  6.079  11.246  1.00 30.91 ? 55  ARG L CZ  1 
ATOM   2724 N NH1 . ARG C 3 55  ? 23.058  6.033  10.519  1.00 30.19 ? 55  ARG L NH1 1 
ATOM   2725 N NH2 . ARG C 3 55  ? 21.239  4.967  11.422  1.00 31.70 ? 55  ARG L NH2 1 
ATOM   2726 N N   . ALA C 3 56  ? 21.662  12.975 8.331   1.00 15.99 ? 56  ALA L N   1 
ATOM   2727 C CA  . ALA C 3 56  ? 22.095  14.364 8.352   1.00 17.19 ? 56  ALA L CA  1 
ATOM   2728 C C   . ALA C 3 56  ? 23.011  14.623 9.550   1.00 18.89 ? 56  ALA L C   1 
ATOM   2729 O O   . ALA C 3 56  ? 23.099  13.827 10.485  1.00 17.10 ? 56  ALA L O   1 
ATOM   2730 C CB  . ALA C 3 56  ? 20.891  15.306 8.399   1.00 16.85 ? 56  ALA L CB  1 
ATOM   2731 N N   . THR C 3 57  ? 23.688  15.772 9.520   1.00 23.22 ? 57  THR L N   1 
ATOM   2732 C CA  . THR C 3 57  ? 24.667  16.089 10.555  1.00 22.24 ? 57  THR L CA  1 
ATOM   2733 C C   . THR C 3 57  ? 23.999  16.168 11.921  1.00 19.62 ? 57  THR L C   1 
ATOM   2734 O O   . THR C 3 57  ? 22.913  16.736 12.072  1.00 22.87 ? 57  THR L O   1 
ATOM   2735 C CB  . THR C 3 57  ? 25.390  17.411 10.241  1.00 27.74 ? 57  THR L CB  1 
ATOM   2736 O OG1 . THR C 3 57  ? 26.343  17.688 11.277  1.00 30.51 ? 57  THR L OG1 1 
ATOM   2737 C CG2 . THR C 3 57  ? 24.409  18.581 10.158  1.00 27.33 ? 57  THR L CG2 1 
ATOM   2738 N N   . GLY C 3 58  ? 24.640  15.555 12.915  1.00 23.73 ? 58  GLY L N   1 
ATOM   2739 C CA  . GLY C 3 58  ? 24.146  15.592 14.279  1.00 23.26 ? 58  GLY L CA  1 
ATOM   2740 C C   . GLY C 3 58  ? 22.934  14.732 14.565  1.00 25.36 ? 58  GLY L C   1 
ATOM   2741 O O   . GLY C 3 58  ? 22.444  14.750 15.703  1.00 25.49 ? 58  GLY L O   1 
ATOM   2742 N N   . ILE C 3 59  ? 22.435  13.982 13.591  1.00 19.31 ? 59  ILE L N   1 
ATOM   2743 C CA  . ILE C 3 59  ? 21.222  13.182 13.802  1.00 22.02 ? 59  ILE L CA  1 
ATOM   2744 C C   . ILE C 3 59  ? 21.599  11.887 14.509  1.00 20.96 ? 59  ILE L C   1 
ATOM   2745 O O   . ILE C 3 59  ? 22.545  11.203 14.075  1.00 21.13 ? 59  ILE L O   1 
ATOM   2746 C CB  . ILE C 3 59  ? 20.518  12.902 12.474  1.00 19.26 ? 59  ILE L CB  1 
ATOM   2747 C CG1 . ILE C 3 59  ? 20.077  14.218 11.829  1.00 17.34 ? 59  ILE L CG1 1 
ATOM   2748 C CG2 . ILE C 3 59  ? 19.304  11.981 12.680  1.00 18.22 ? 59  ILE L CG2 1 
ATOM   2749 C CD1 . ILE C 3 59  ? 19.076  14.999 12.666  1.00 19.45 ? 59  ILE L CD1 1 
ATOM   2750 N N   . PRO C 3 60  ? 20.889  11.512 15.574  1.00 19.93 ? 60  PRO L N   1 
ATOM   2751 C CA  . PRO C 3 60  ? 21.241  10.302 16.330  1.00 21.58 ? 60  PRO L CA  1 
ATOM   2752 C C   . PRO C 3 60  ? 21.051  9.009  15.545  1.00 23.62 ? 60  PRO L C   1 
ATOM   2753 O O   . PRO C 3 60  ? 20.251  8.912  14.606  1.00 19.54 ? 60  PRO L O   1 
ATOM   2754 C CB  . PRO C 3 60  ? 20.292  10.348 17.535  1.00 20.91 ? 60  PRO L CB  1 
ATOM   2755 C CG  . PRO C 3 60  ? 19.852  11.768 17.639  1.00 26.10 ? 60  PRO L CG  1 
ATOM   2756 C CD  . PRO C 3 60  ? 19.825  12.290 16.233  1.00 23.17 ? 60  PRO L CD  1 
ATOM   2757 N N   . ASP C 3 61  ? 21.777  7.985  16.023  1.00 23.17 ? 61  ASP L N   1 
ATOM   2758 C CA  . ASP C 3 61  ? 21.834  6.662  15.401  1.00 26.25 ? 61  ASP L CA  1 
ATOM   2759 C C   . ASP C 3 61  ? 20.470  5.995  15.296  1.00 20.88 ? 61  ASP L C   1 
ATOM   2760 O O   . ASP C 3 61  ? 20.268  5.139  14.425  1.00 19.83 ? 61  ASP L O   1 
ATOM   2761 C CB  . ASP C 3 61  ? 22.756  5.743  16.212  1.00 28.94 ? 61  ASP L CB  1 
ATOM   2762 C CG  . ASP C 3 61  ? 24.212  5.902  15.852  1.00 37.66 ? 61  ASP L CG  1 
ATOM   2763 O OD1 . ASP C 3 61  ? 24.518  6.678  14.923  1.00 39.39 ? 61  ASP L OD1 1 
ATOM   2764 O OD2 . ASP C 3 61  ? 25.053  5.238  16.502  1.00 44.94 ? 61  ASP L OD2 1 
ATOM   2765 N N   . ARG C 3 62  ? 19.539  6.334  16.186  1.00 18.11 ? 62  ARG L N   1 
ATOM   2766 C CA  . ARG C 3 62  ? 18.280  5.604  16.215  1.00 19.71 ? 62  ARG L CA  1 
ATOM   2767 C C   . ARG C 3 62  ? 17.416  5.888  14.996  1.00 18.72 ? 62  ARG L C   1 
ATOM   2768 O O   . ARG C 3 62  ? 16.482  5.124  14.729  1.00 17.11 ? 62  ARG L O   1 
ATOM   2769 C CB  . ARG C 3 62  ? 17.506  5.917  17.494  1.00 19.41 ? 62  ARG L CB  1 
ATOM   2770 C CG  . ARG C 3 62  ? 17.024  7.348  17.654  1.00 17.46 ? 62  ARG L CG  1 
ATOM   2771 C CD  . ARG C 3 62  ? 16.306  7.501  18.994  1.00 17.94 ? 62  ARG L CD  1 
ATOM   2772 N NE  . ARG C 3 62  ? 15.848  8.865  19.213  1.00 20.01 ? 62  ARG L NE  1 
ATOM   2773 C CZ  . ARG C 3 62  ? 16.627  9.846  19.644  1.00 21.40 ? 62  ARG L CZ  1 
ATOM   2774 N NH1 . ARG C 3 62  ? 17.889  9.631  19.972  1.00 20.88 ? 62  ARG L NH1 1 
ATOM   2775 N NH2 . ARG C 3 62  ? 16.133  11.077 19.727  1.00 20.79 ? 62  ARG L NH2 1 
ATOM   2776 N N   . PHE C 3 63  ? 17.709  6.955  14.246  1.00 16.46 ? 63  PHE L N   1 
ATOM   2777 C CA  . PHE C 3 63  ? 17.001  7.257  13.004  1.00 15.84 ? 63  PHE L CA  1 
ATOM   2778 C C   . PHE C 3 63  ? 17.717  6.570  11.845  1.00 17.29 ? 63  PHE L C   1 
ATOM   2779 O O   . PHE C 3 63  ? 18.918  6.770  11.649  1.00 18.26 ? 63  PHE L O   1 
ATOM   2780 C CB  . PHE C 3 63  ? 16.942  8.769  12.766  1.00 15.51 ? 63  PHE L CB  1 
ATOM   2781 C CG  . PHE C 3 63  ? 16.129  9.517  13.782  1.00 13.75 ? 63  PHE L CG  1 
ATOM   2782 C CD1 . PHE C 3 63  ? 14.767  9.665  13.628  1.00 13.35 ? 63  PHE L CD1 1 
ATOM   2783 C CD2 . PHE C 3 63  ? 16.733  10.080 14.890  1.00 17.26 ? 63  PHE L CD2 1 
ATOM   2784 C CE1 . PHE C 3 63  ? 14.020  10.351 14.566  1.00 16.48 ? 63  PHE L CE1 1 
ATOM   2785 C CE2 . PHE C 3 63  ? 15.993  10.764 15.826  1.00 18.14 ? 63  PHE L CE2 1 
ATOM   2786 C CZ  . PHE C 3 63  ? 14.637  10.905 15.670  1.00 16.25 ? 63  PHE L CZ  1 
ATOM   2787 N N   . SER C 3 64  ? 16.990  5.775  11.070  1.00 17.05 ? 64  SER L N   1 
ATOM   2788 C CA  . SER C 3 64  ? 17.556  5.222  9.848   1.00 16.27 ? 64  SER L CA  1 
ATOM   2789 C C   . SER C 3 64  ? 16.493  5.220  8.760   1.00 18.21 ? 64  SER L C   1 
ATOM   2790 O O   . SER C 3 64  ? 15.294  5.204  9.037   1.00 18.76 ? 64  SER L O   1 
ATOM   2791 C CB  . SER C 3 64  ? 18.102  3.808  10.062  1.00 21.11 ? 64  SER L CB  1 
ATOM   2792 O OG  . SER C 3 64  ? 17.061  2.927  10.423  1.00 21.82 ? 64  SER L OG  1 
ATOM   2793 N N   . GLY C 3 65  ? 16.952  5.263  7.510   1.00 17.33 ? 65  GLY L N   1 
ATOM   2794 C CA  . GLY C 3 65  ? 16.061  5.215  6.374   1.00 15.31 ? 65  GLY L CA  1 
ATOM   2795 C C   . GLY C 3 65  ? 16.467  4.091  5.443   1.00 17.26 ? 65  GLY L C   1 
ATOM   2796 O O   . GLY C 3 65  ? 17.624  3.668  5.411   1.00 18.95 ? 65  GLY L O   1 
ATOM   2797 N N   . SER C 3 66  ? 15.490  3.604  4.683   1.00 20.10 ? 66  SER L N   1 
ATOM   2798 C CA  . SER C 3 66  ? 15.747  2.551  3.710   1.00 18.61 ? 66  SER L CA  1 
ATOM   2799 C C   . SER C 3 66  ? 14.790  2.716  2.541   1.00 17.69 ? 66  SER L C   1 
ATOM   2800 O O   . SER C 3 66  ? 13.887  3.561  2.557   1.00 15.88 ? 66  SER L O   1 
ATOM   2801 C CB  . SER C 3 66  ? 15.605  1.164  4.346   1.00 16.68 ? 66  SER L CB  1 
ATOM   2802 O OG  . SER C 3 66  ? 14.281  0.979  4.832   1.00 22.37 ? 66  SER L OG  1 
ATOM   2803 N N   . GLY C 3 67  ? 14.999  1.904  1.517   1.00 18.69 ? 67  GLY L N   1 
ATOM   2804 C CA  . GLY C 3 67  ? 14.106  1.857  0.381   1.00 16.02 ? 67  GLY L CA  1 
ATOM   2805 C C   . GLY C 3 67  ? 14.789  2.258  -0.909  1.00 17.26 ? 67  GLY L C   1 
ATOM   2806 O O   . GLY C 3 67  ? 15.956  2.647  -0.938  1.00 19.48 ? 67  GLY L O   1 
ATOM   2807 N N   . SER C 3 68  ? 14.023  2.151  -1.993  1.00 15.29 ? 68  SER L N   1 
ATOM   2808 C CA  . SER C 3 68  ? 14.505  2.445  -3.337  1.00 18.87 ? 68  SER L CA  1 
ATOM   2809 C C   . SER C 3 68  ? 13.293  2.472  -4.253  1.00 17.00 ? 68  SER L C   1 
ATOM   2810 O O   . SER C 3 68  ? 12.203  2.041  -3.876  1.00 20.48 ? 68  SER L O   1 
ATOM   2811 C CB  . SER C 3 68  ? 15.525  1.404  -3.812  1.00 20.42 ? 68  SER L CB  1 
ATOM   2812 O OG  . SER C 3 68  ? 14.905  0.131  -3.934  1.00 21.45 ? 68  SER L OG  1 
ATOM   2813 N N   . GLY C 3 69  ? 13.495  2.961  -5.469  1.00 19.79 ? 69  GLY L N   1 
ATOM   2814 C CA  . GLY C 3 69  ? 12.403  3.038  -6.420  1.00 18.64 ? 69  GLY L CA  1 
ATOM   2815 C C   . GLY C 3 69  ? 11.311  4.004  -6.011  1.00 19.96 ? 69  GLY L C   1 
ATOM   2816 O O   . GLY C 3 69  ? 11.488  5.225  -6.089  1.00 18.70 ? 69  GLY L O   1 
ATOM   2817 N N   . THR C 3 70  ? 10.167  3.467  -5.577  1.00 20.88 ? 70  THR L N   1 
ATOM   2818 C CA  . THR C 3 70  ? 9.035   4.277  -5.140  1.00 21.78 ? 70  THR L CA  1 
ATOM   2819 C C   . THR C 3 70  ? 8.699   4.089  -3.668  1.00 21.06 ? 70  THR L C   1 
ATOM   2820 O O   . THR C 3 70  ? 7.760   4.722  -3.179  1.00 22.05 ? 70  THR L O   1 
ATOM   2821 C CB  . THR C 3 70  ? 7.774   3.946  -5.956  1.00 21.78 ? 70  THR L CB  1 
ATOM   2822 O OG1 . THR C 3 70  ? 7.466   2.554  -5.812  1.00 22.04 ? 70  THR L OG1 1 
ATOM   2823 C CG2 . THR C 3 70  ? 7.942   4.303  -7.411  1.00 20.87 ? 70  THR L CG2 1 
ATOM   2824 N N   . ASP C 3 71  ? 9.447   3.267  -2.950  1.00 20.26 ? 71  ASP L N   1 
ATOM   2825 C CA  . ASP C 3 71  ? 9.038   2.721  -1.661  1.00 20.87 ? 71  ASP L CA  1 
ATOM   2826 C C   . ASP C 3 71  ? 10.110  3.016  -0.623  1.00 20.38 ? 71  ASP L C   1 
ATOM   2827 O O   . ASP C 3 71  ? 11.193  2.426  -0.666  1.00 20.60 ? 71  ASP L O   1 
ATOM   2828 C CB  . ASP C 3 71  ? 8.830   1.220  -1.804  1.00 26.51 ? 71  ASP L CB  1 
ATOM   2829 C CG  . ASP C 3 71  ? 7.569   0.751  -1.176  1.00 41.09 ? 71  ASP L CG  1 
ATOM   2830 O OD1 . ASP C 3 71  ? 7.450   0.872  0.069   1.00 43.78 ? 71  ASP L OD1 1 
ATOM   2831 O OD2 . ASP C 3 71  ? 6.706   0.248  -1.932  1.00 44.07 ? 71  ASP L OD2 1 
ATOM   2832 N N   . PHE C 3 72  ? 9.811   3.900  0.328   1.00 16.77 ? 72  PHE L N   1 
ATOM   2833 C CA  . PHE C 3 72  ? 10.811  4.335  1.289   1.00 16.15 ? 72  PHE L CA  1 
ATOM   2834 C C   . PHE C 3 72  ? 10.255  4.251  2.698   1.00 15.43 ? 72  PHE L C   1 
ATOM   2835 O O   . PHE C 3 72  ? 9.041   4.292  2.907   1.00 15.84 ? 72  PHE L O   1 
ATOM   2836 C CB  . PHE C 3 72  ? 11.280  5.754  0.955   1.00 14.68 ? 72  PHE L CB  1 
ATOM   2837 C CG  . PHE C 3 72  ? 11.922  5.847  -0.394  1.00 13.99 ? 72  PHE L CG  1 
ATOM   2838 C CD1 . PHE C 3 72  ? 13.284  5.598  -0.551  1.00 17.30 ? 72  PHE L CD1 1 
ATOM   2839 C CD2 . PHE C 3 72  ? 11.157  6.133  -1.513  1.00 15.45 ? 72  PHE L CD2 1 
ATOM   2840 C CE1 . PHE C 3 72  ? 13.873  5.655  -1.812  1.00 16.43 ? 72  PHE L CE1 1 
ATOM   2841 C CE2 . PHE C 3 72  ? 11.739  6.198  -2.772  1.00 16.72 ? 72  PHE L CE2 1 
ATOM   2842 C CZ  . PHE C 3 72  ? 13.089  5.962  -2.916  1.00 15.70 ? 72  PHE L CZ  1 
ATOM   2843 N N   . THR C 3 73  ? 11.157  4.085  3.660   1.00 13.76 ? 73  THR L N   1 
ATOM   2844 C CA  . THR C 3 73  ? 10.780  3.847  5.045   1.00 16.46 ? 73  THR L CA  1 
ATOM   2845 C C   . THR C 3 73  ? 11.734  4.597  5.961   1.00 15.57 ? 73  THR L C   1 
ATOM   2846 O O   . THR C 3 73  ? 12.949  4.599  5.743   1.00 15.99 ? 73  THR L O   1 
ATOM   2847 C CB  . THR C 3 73  ? 10.798  2.335  5.401   1.00 19.28 ? 73  THR L CB  1 
ATOM   2848 O OG1 . THR C 3 73  ? 12.104  1.808  5.174   1.00 28.38 ? 73  THR L OG1 1 
ATOM   2849 C CG2 . THR C 3 73  ? 9.827   1.559  4.539   1.00 16.13 ? 73  THR L CG2 1 
ATOM   2850 N N   . LEU C 3 74  ? 11.175  5.247  6.971   1.00 13.52 ? 74  LEU L N   1 
ATOM   2851 C CA  . LEU C 3 74  ? 11.927  5.840  8.066   1.00 11.25 ? 74  LEU L CA  1 
ATOM   2852 C C   . LEU C 3 74  ? 11.677  4.982  9.294   1.00 15.73 ? 74  LEU L C   1 
ATOM   2853 O O   . LEU C 3 74  ? 10.522  4.666  9.609   1.00 13.32 ? 74  LEU L O   1 
ATOM   2854 C CB  . LEU C 3 74  ? 11.507  7.289  8.339   1.00 12.63 ? 74  LEU L CB  1 
ATOM   2855 C CG  . LEU C 3 74  ? 12.127  7.972  9.580   1.00 10.53 ? 74  LEU L CG  1 
ATOM   2856 C CD1 . LEU C 3 74  ? 13.630  8.164  9.417   1.00 13.69 ? 74  LEU L CD1 1 
ATOM   2857 C CD2 . LEU C 3 74  ? 11.461  9.315  9.898   1.00 12.33 ? 74  LEU L CD2 1 
ATOM   2858 N N   . THR C 3 75  ? 12.756  4.595  9.969   1.00 14.83 ? 75  THR L N   1 
ATOM   2859 C CA  . THR C 3 75  ? 12.681  3.776  11.169  1.00 16.86 ? 75  THR L CA  1 
ATOM   2860 C C   . THR C 3 75  ? 13.323  4.534  12.320  1.00 16.09 ? 75  THR L C   1 
ATOM   2861 O O   . THR C 3 75  ? 14.430  5.060  12.179  1.00 16.08 ? 75  THR L O   1 
ATOM   2862 C CB  . THR C 3 75  ? 13.385  2.426  10.961  1.00 17.67 ? 75  THR L CB  1 
ATOM   2863 O OG1 . THR C 3 75  ? 12.773  1.719  9.871   1.00 16.73 ? 75  THR L OG1 1 
ATOM   2864 C CG2 . THR C 3 75  ? 13.303  1.590  12.225  1.00 19.82 ? 75  THR L CG2 1 
ATOM   2865 N N   . ILE C 3 76  ? 12.614  4.627  13.440  1.00 16.48 ? 76  ILE L N   1 
ATOM   2866 C CA  . ILE C 3 76  ? 13.185  5.071  14.706  1.00 12.91 ? 76  ILE L CA  1 
ATOM   2867 C C   . ILE C 3 76  ? 13.254  3.824  15.575  1.00 17.75 ? 76  ILE L C   1 
ATOM   2868 O O   . ILE C 3 76  ? 12.213  3.266  15.949  1.00 16.96 ? 76  ILE L O   1 
ATOM   2869 C CB  . ILE C 3 76  ? 12.347  6.171  15.370  1.00 16.19 ? 76  ILE L CB  1 
ATOM   2870 C CG1 . ILE C 3 76  ? 11.963  7.262  14.362  1.00 15.43 ? 76  ILE L CG1 1 
ATOM   2871 C CG2 . ILE C 3 76  ? 13.101  6.755  16.572  1.00 16.65 ? 76  ILE L CG2 1 
ATOM   2872 C CD1 . ILE C 3 76  ? 10.975  8.274  14.909  1.00 15.55 ? 76  ILE L CD1 1 
ATOM   2873 N N   . SER C 3 77  ? 14.477  3.363  15.869  1.00 18.93 ? 77  SER L N   1 
ATOM   2874 C CA  . SER C 3 77  ? 14.652  2.017  16.419  1.00 19.33 ? 77  SER L CA  1 
ATOM   2875 C C   . SER C 3 77  ? 14.011  1.892  17.793  1.00 19.29 ? 77  SER L C   1 
ATOM   2876 O O   . SER C 3 77  ? 13.285  0.924  18.065  1.00 22.24 ? 77  SER L O   1 
ATOM   2877 C CB  . SER C 3 77  ? 16.138  1.677  16.491  1.00 16.68 ? 77  SER L CB  1 
ATOM   2878 O OG  . SER C 3 77  ? 16.812  2.644  17.275  1.00 19.30 ? 77  SER L OG  1 
ATOM   2879 N N   . ARG C 3 78  ? 14.253  2.879  18.661  1.00 18.26 ? 78  ARG L N   1 
ATOM   2880 C CA  . ARG C 3 78  ? 13.737  2.932  20.029  1.00 18.67 ? 78  ARG L CA  1 
ATOM   2881 C C   . ARG C 3 78  ? 13.368  4.379  20.312  1.00 17.48 ? 78  ARG L C   1 
ATOM   2882 O O   . ARG C 3 78  ? 14.261  5.207  20.530  1.00 19.92 ? 78  ARG L O   1 
ATOM   2883 C CB  . ARG C 3 78  ? 14.774  2.437  21.042  1.00 20.28 ? 78  ARG L CB  1 
ATOM   2884 C CG  . ARG C 3 78  ? 15.044  0.946  20.963  1.00 22.89 ? 78  ARG L CG  1 
ATOM   2885 C CD  . ARG C 3 78  ? 16.395  0.558  21.547  1.00 26.03 ? 78  ARG L CD  1 
ATOM   2886 N NE  . ARG C 3 78  ? 16.688  -0.845 21.265  1.00 34.12 ? 78  ARG L NE  1 
ATOM   2887 C CZ  . ARG C 3 78  ? 17.380  -1.270 20.213  1.00 36.02 ? 78  ARG L CZ  1 
ATOM   2888 N NH1 . ARG C 3 78  ? 17.936  -0.418 19.362  1.00 36.63 ? 78  ARG L NH1 1 
ATOM   2889 N NH2 . ARG C 3 78  ? 17.523  -2.580 20.015  1.00 34.29 ? 78  ARG L NH2 1 
ATOM   2890 N N   . LEU C 3 79  ? 12.069  4.675  20.333  1.00 17.08 ? 79  LEU L N   1 
ATOM   2891 C CA  . LEU C 3 79  ? 11.599  6.049  20.456  1.00 14.68 ? 79  LEU L CA  1 
ATOM   2892 C C   . LEU C 3 79  ? 12.014  6.674  21.780  1.00 21.27 ? 79  LEU L C   1 
ATOM   2893 O O   . LEU C 3 79  ? 11.874  6.063  22.844  1.00 20.17 ? 79  LEU L O   1 
ATOM   2894 C CB  . LEU C 3 79  ? 10.076  6.100  20.351  1.00 13.66 ? 79  LEU L CB  1 
ATOM   2895 C CG  . LEU C 3 79  ? 9.451   5.875  18.986  1.00 16.93 ? 79  LEU L CG  1 
ATOM   2896 C CD1 . LEU C 3 79  ? 7.978   5.553  19.138  1.00 15.08 ? 79  LEU L CD1 1 
ATOM   2897 C CD2 . LEU C 3 79  ? 9.633   7.133  18.157  1.00 17.67 ? 79  LEU L CD2 1 
ATOM   2898 N N   . GLU C 3 80  ? 12.497  7.923  21.711  1.00 17.71 ? 80  GLU L N   1 
ATOM   2899 C CA  . GLU C 3 80  ? 12.674  8.779  22.873  1.00 21.59 ? 80  GLU L CA  1 
ATOM   2900 C C   . GLU C 3 80  ? 11.533  9.787  22.962  1.00 19.41 ? 80  GLU L C   1 
ATOM   2901 O O   . GLU C 3 80  ? 10.834  10.046 21.973  1.00 16.61 ? 80  GLU L O   1 
ATOM   2902 C CB  . GLU C 3 80  ? 14.022  9.509  22.802  1.00 20.17 ? 80  GLU L CB  1 
ATOM   2903 C CG  . GLU C 3 80  ? 15.221  8.591  22.689  1.00 22.56 ? 80  GLU L CG  1 
ATOM   2904 C CD  . GLU C 3 80  ? 15.496  7.804  23.965  1.00 26.99 ? 80  GLU L CD  1 
ATOM   2905 O OE1 . GLU C 3 80  ? 15.223  8.326  25.067  1.00 27.92 ? 80  GLU L OE1 1 
ATOM   2906 O OE2 . GLU C 3 80  ? 15.983  6.658  23.862  1.00 28.52 ? 80  GLU L OE2 1 
ATOM   2907 N N   . PRO C 3 81  ? 11.296  10.371 24.142  1.00 20.77 ? 81  PRO L N   1 
ATOM   2908 C CA  . PRO C 3 81  ? 10.132  11.266 24.280  1.00 20.46 ? 81  PRO L CA  1 
ATOM   2909 C C   . PRO C 3 81  ? 10.153  12.442 23.319  1.00 19.05 ? 81  PRO L C   1 
ATOM   2910 O O   . PRO C 3 81  ? 9.085   12.908 22.899  1.00 18.46 ? 81  PRO L O   1 
ATOM   2911 C CB  . PRO C 3 81  ? 10.217  11.727 25.744  1.00 22.95 ? 81  PRO L CB  1 
ATOM   2912 C CG  . PRO C 3 81  ? 10.996  10.649 26.436  1.00 18.23 ? 81  PRO L CG  1 
ATOM   2913 C CD  . PRO C 3 81  ? 12.009  10.197 25.426  1.00 23.21 ? 81  PRO L CD  1 
ATOM   2914 N N   . GLU C 3 82  ? 11.343  12.934 22.955  1.00 21.08 ? 82  GLU L N   1 
ATOM   2915 C CA  . GLU C 3 82  ? 11.449  14.066 22.042  1.00 21.96 ? 82  GLU L CA  1 
ATOM   2916 C C   . GLU C 3 82  ? 11.124  13.694 20.600  1.00 21.25 ? 82  GLU L C   1 
ATOM   2917 O O   . GLU C 3 82  ? 11.005  14.593 19.758  1.00 20.82 ? 82  GLU L O   1 
ATOM   2918 C CB  . GLU C 3 82  ? 12.853  14.661 22.120  1.00 23.19 ? 82  GLU L CB  1 
ATOM   2919 C CG  . GLU C 3 82  ? 13.960  13.687 21.708  1.00 25.84 ? 82  GLU L CG  1 
ATOM   2920 C CD  . GLU C 3 82  ? 14.608  12.972 22.889  1.00 30.02 ? 82  GLU L CD  1 
ATOM   2921 O OE1 . GLU C 3 82  ? 13.972  12.845 23.972  1.00 25.95 ? 82  GLU L OE1 1 
ATOM   2922 O OE2 . GLU C 3 82  ? 15.779  12.543 22.727  1.00 35.00 ? 82  GLU L OE2 1 
ATOM   2923 N N   . ASP C 3 83  ? 10.963  12.401 20.298  1.00 17.08 ? 83  ASP L N   1 
ATOM   2924 C CA  . ASP C 3 83  ? 10.665  11.944 18.947  1.00 15.77 ? 83  ASP L CA  1 
ATOM   2925 C C   . ASP C 3 83  ? 9.185   12.009 18.596  1.00 16.01 ? 83  ASP L C   1 
ATOM   2926 O O   . ASP C 3 83  ? 8.828   11.754 17.439  1.00 15.57 ? 83  ASP L O   1 
ATOM   2927 C CB  . ASP C 3 83  ? 11.139  10.506 18.761  1.00 15.46 ? 83  ASP L CB  1 
ATOM   2928 C CG  . ASP C 3 83  ? 12.616  10.337 19.000  1.00 19.66 ? 83  ASP L CG  1 
ATOM   2929 O OD1 . ASP C 3 83  ? 13.394  11.324 18.937  1.00 19.52 ? 83  ASP L OD1 1 
ATOM   2930 O OD2 . ASP C 3 83  ? 13.013  9.185  19.243  1.00 17.76 ? 83  ASP L OD2 1 
ATOM   2931 N N   . PHE C 3 84  ? 8.311   12.302 19.550  1.00 15.03 ? 84  PHE L N   1 
ATOM   2932 C CA  . PHE C 3 84  ? 6.894   12.437 19.245  1.00 15.35 ? 84  PHE L CA  1 
ATOM   2933 C C   . PHE C 3 84  ? 6.696   13.798 18.589  1.00 17.17 ? 84  PHE L C   1 
ATOM   2934 O O   . PHE C 3 84  ? 6.850   14.846 19.231  1.00 16.56 ? 84  PHE L O   1 
ATOM   2935 C CB  . PHE C 3 84  ? 6.066   12.215 20.504  1.00 15.39 ? 84  PHE L CB  1 
ATOM   2936 C CG  . PHE C 3 84  ? 6.193   10.808 21.017  1.00 16.64 ? 84  PHE L CG  1 
ATOM   2937 C CD1 . PHE C 3 84  ? 7.187   10.470 21.920  1.00 20.83 ? 84  PHE L CD1 1 
ATOM   2938 C CD2 . PHE C 3 84  ? 5.374   9.800  20.515  1.00 14.42 ? 84  PHE L CD2 1 
ATOM   2939 C CE1 . PHE C 3 84  ? 7.332   9.151  22.360  1.00 20.07 ? 84  PHE L CE1 1 
ATOM   2940 C CE2 . PHE C 3 84  ? 5.513   8.482  20.940  1.00 17.36 ? 84  PHE L CE2 1 
ATOM   2941 C CZ  . PHE C 3 84  ? 6.489   8.159  21.865  1.00 19.12 ? 84  PHE L CZ  1 
ATOM   2942 N N   . ALA C 3 85  ? 6.439   13.766 17.284  1.00 13.97 ? 85  ALA L N   1 
ATOM   2943 C CA  . ALA C 3 85  ? 6.438   14.924 16.395  1.00 12.12 ? 85  ALA L CA  1 
ATOM   2944 C C   . ALA C 3 85  ? 5.824   14.464 15.077  1.00 15.50 ? 85  ALA L C   1 
ATOM   2945 O O   . ALA C 3 85  ? 5.370   13.322 14.947  1.00 13.82 ? 85  ALA L O   1 
ATOM   2946 C CB  . ALA C 3 85  ? 7.854   15.464 16.189  1.00 15.22 ? 85  ALA L CB  1 
ATOM   2947 N N   . VAL C 3 86  ? 5.830   15.350 14.091  1.00 14.07 ? 86  VAL L N   1 
ATOM   2948 C CA  . VAL C 3 86  ? 5.327   15.026 12.761  1.00 13.15 ? 86  VAL L CA  1 
ATOM   2949 C C   . VAL C 3 86  ? 6.524   14.816 11.854  1.00 12.34 ? 86  VAL L C   1 
ATOM   2950 O O   . VAL C 3 86  ? 7.529   15.519 11.975  1.00 11.14 ? 86  VAL L O   1 
ATOM   2951 C CB  . VAL C 3 86  ? 4.398   16.136 12.241  1.00 13.07 ? 86  VAL L CB  1 
ATOM   2952 C CG1 . VAL C 3 86  ? 3.892   15.822 10.842  1.00 13.48 ? 86  VAL L CG1 1 
ATOM   2953 C CG2 . VAL C 3 86  ? 3.203   16.309 13.190  1.00 13.69 ? 86  VAL L CG2 1 
ATOM   2954 N N   . TYR C 3 87  ? 6.432   13.836 10.954  1.00 11.11 ? 87  TYR L N   1 
ATOM   2955 C CA  . TYR C 3 87  ? 7.518   13.481 10.059  1.00 10.28 ? 87  TYR L CA  1 
ATOM   2956 C C   . TYR C 3 87  ? 7.040   13.569 8.614   1.00 10.79 ? 87  TYR L C   1 
ATOM   2957 O O   . TYR C 3 87  ? 5.982   13.027 8.274   1.00 11.25 ? 87  TYR L O   1 
ATOM   2958 C CB  . TYR C 3 87  ? 8.030   12.073 10.382  1.00 11.58 ? 87  TYR L CB  1 
ATOM   2959 C CG  . TYR C 3 87  ? 8.679   11.996 11.754  1.00 9.59  ? 87  TYR L CG  1 
ATOM   2960 C CD1 . TYR C 3 87  ? 7.899   11.832 12.907  1.00 12.02 ? 87  TYR L CD1 1 
ATOM   2961 C CD2 . TYR C 3 87  ? 10.052  12.106 11.897  1.00 10.96 ? 87  TYR L CD2 1 
ATOM   2962 C CE1 . TYR C 3 87  ? 8.493   11.777 14.171  1.00 10.75 ? 87  TYR L CE1 1 
ATOM   2963 C CE2 . TYR C 3 87  ? 10.655  12.054 13.137  1.00 11.69 ? 87  TYR L CE2 1 
ATOM   2964 C CZ  . TYR C 3 87  ? 9.873   11.894 14.267  1.00 10.21 ? 87  TYR L CZ  1 
ATOM   2965 O OH  . TYR C 3 87  ? 10.517  11.852 15.479  1.00 13.98 ? 87  TYR L OH  1 
ATOM   2966 N N   . TYR C 3 88  ? 7.830   14.242 7.769   1.00 10.98 ? 88  TYR L N   1 
ATOM   2967 C CA  . TYR C 3 88  ? 7.520   14.455 6.358   1.00 11.54 ? 88  TYR L CA  1 
ATOM   2968 C C   . TYR C 3 88  ? 8.594   13.821 5.492   1.00 11.80 ? 88  TYR L C   1 
ATOM   2969 O O   . TYR C 3 88  ? 9.783   13.916 5.801   1.00 11.63 ? 88  TYR L O   1 
ATOM   2970 C CB  . TYR C 3 88  ? 7.439   15.969 6.005   1.00 10.00 ? 88  TYR L CB  1 
ATOM   2971 C CG  . TYR C 3 88  ? 6.318   16.720 6.667   1.00 10.43 ? 88  TYR L CG  1 
ATOM   2972 C CD1 . TYR C 3 88  ? 5.051   16.757 6.110   1.00 11.60 ? 88  TYR L CD1 1 
ATOM   2973 C CD2 . TYR C 3 88  ? 6.536   17.399 7.854   1.00 10.25 ? 88  TYR L CD2 1 
ATOM   2974 C CE1 . TYR C 3 88  ? 4.041   17.456 6.716   1.00 12.45 ? 88  TYR L CE1 1 
ATOM   2975 C CE2 . TYR C 3 88  ? 5.540   18.078 8.479   1.00 13.83 ? 88  TYR L CE2 1 
ATOM   2976 C CZ  . TYR C 3 88  ? 4.294   18.110 7.914   1.00 13.32 ? 88  TYR L CZ  1 
ATOM   2977 O OH  . TYR C 3 88  ? 3.296   18.813 8.531   1.00 13.22 ? 88  TYR L OH  1 
ATOM   2978 N N   . CYS C 3 89  ? 8.188   13.189 4.400   1.00 10.03 ? 89  CYS L N   1 
ATOM   2979 C CA  . CYS C 3 89  ? 9.155   12.833 3.374   1.00 10.44 ? 89  CYS L CA  1 
ATOM   2980 C C   . CYS C 3 89  ? 9.092   13.866 2.258   1.00 11.37 ? 89  CYS L C   1 
ATOM   2981 O O   . CYS C 3 89  ? 8.164   14.664 2.179   1.00 10.73 ? 89  CYS L O   1 
ATOM   2982 C CB  . CYS C 3 89  ? 8.909   11.428 2.821   1.00 13.46 ? 89  CYS L CB  1 
ATOM   2983 S SG  . CYS C 3 89  ? 7.308   11.154 2.085   1.00 15.08 ? 89  CYS L SG  1 
ATOM   2984 N N   . GLN C 3 90  ? 10.109  13.856 1.410   1.00 9.90  ? 90  GLN L N   1 
ATOM   2985 C CA  . GLN C 3 90  ? 10.248  14.852 0.360   1.00 10.29 ? 90  GLN L CA  1 
ATOM   2986 C C   . GLN C 3 90  ? 11.106  14.262 -0.738  1.00 9.51  ? 90  GLN L C   1 
ATOM   2987 O O   . GLN C 3 90  ? 12.061  13.548 -0.446  1.00 11.86 ? 90  GLN L O   1 
ATOM   2988 C CB  . GLN C 3 90  ? 10.892  16.149 0.890   1.00 9.47  ? 90  GLN L CB  1 
ATOM   2989 C CG  . GLN C 3 90  ? 11.216  17.180 -0.212  1.00 10.87 ? 90  GLN L CG  1 
ATOM   2990 C CD  . GLN C 3 90  ? 12.471  17.998 0.089   1.00 9.80  ? 90  GLN L CD  1 
ATOM   2991 O OE1 . GLN C 3 90  ? 13.497  17.450 0.492   1.00 12.06 ? 90  GLN L OE1 1 
ATOM   2992 N NE2 . GLN C 3 90  ? 12.396  19.306 -0.124  1.00 11.54 ? 90  GLN L NE2 1 
ATOM   2993 N N   . GLN C 3 91  ? 10.771  14.550 -1.993  1.00 10.31 ? 91  GLN L N   1 
ATOM   2994 C CA  . GLN C 3 91  ? 11.693  14.297 -3.091  1.00 11.33 ? 91  GLN L CA  1 
ATOM   2995 C C   . GLN C 3 91  ? 12.334  15.616 -3.500  1.00 8.99  ? 91  GLN L C   1 
ATOM   2996 O O   . GLN C 3 91  ? 11.678  16.664 -3.544  1.00 11.75 ? 91  GLN L O   1 
ATOM   2997 C CB  . GLN C 3 91  ? 11.005  13.621 -4.290  1.00 13.29 ? 91  GLN L CB  1 
ATOM   2998 C CG  . GLN C 3 91  ? 10.021  14.481 -5.089  1.00 12.83 ? 91  GLN L CG  1 
ATOM   2999 C CD  . GLN C 3 91  ? 10.697  15.500 -6.012  1.00 13.08 ? 91  GLN L CD  1 
ATOM   3000 O OE1 . GLN C 3 91  ? 11.854  15.336 -6.418  1.00 12.69 ? 91  GLN L OE1 1 
ATOM   3001 N NE2 . GLN C 3 91  ? 9.989   16.581 -6.300  1.00 12.25 ? 91  GLN L NE2 1 
ATOM   3002 N N   . TYR C 3 92  ? 13.631  15.568 -3.767  1.00 10.71 ? 92  TYR L N   1 
ATOM   3003 C CA  . TYR C 3 92  ? 14.366  16.774 -4.118  1.00 9.61  ? 92  TYR L CA  1 
ATOM   3004 C C   . TYR C 3 92  ? 15.149  16.579 -5.412  1.00 10.91 ? 92  TYR L C   1 
ATOM   3005 O O   . TYR C 3 92  ? 16.106  17.314 -5.669  1.00 13.16 ? 92  TYR L O   1 
ATOM   3006 C CB  . TYR C 3 92  ? 15.274  17.201 -2.955  1.00 10.98 ? 92  TYR L CB  1 
ATOM   3007 C CG  . TYR C 3 92  ? 16.205  16.111 -2.457  1.00 10.91 ? 92  TYR L CG  1 
ATOM   3008 C CD1 . TYR C 3 92  ? 17.433  15.896 -3.073  1.00 11.14 ? 92  TYR L CD1 1 
ATOM   3009 C CD2 . TYR C 3 92  ? 15.868  15.306 -1.367  1.00 12.79 ? 92  TYR L CD2 1 
ATOM   3010 C CE1 . TYR C 3 92  ? 18.303  14.917 -2.619  1.00 11.97 ? 92  TYR L CE1 1 
ATOM   3011 C CE2 . TYR C 3 92  ? 16.726  14.312 -0.918  1.00 11.03 ? 92  TYR L CE2 1 
ATOM   3012 C CZ  . TYR C 3 92  ? 17.932  14.124 -1.545  1.00 12.42 ? 92  TYR L CZ  1 
ATOM   3013 O OH  . TYR C 3 92  ? 18.776  13.153 -1.098  1.00 14.52 ? 92  TYR L OH  1 
ATOM   3014 N N   . GLY C 3 93  ? 14.736  15.610 -6.241  1.00 11.41 ? 93  GLY L N   1 
ATOM   3015 C CA  . GLY C 3 93  ? 15.423  15.347 -7.488  1.00 14.61 ? 93  GLY L CA  1 
ATOM   3016 C C   . GLY C 3 93  ? 15.014  16.254 -8.625  1.00 14.69 ? 93  GLY L C   1 
ATOM   3017 O O   . GLY C 3 93  ? 15.759  16.348 -9.605  1.00 17.43 ? 93  GLY L O   1 
ATOM   3018 N N   . GLN C 3 94  ? 13.859  16.918 -8.525  1.00 14.23 ? 94  GLN L N   1 
ATOM   3019 C CA  . GLN C 3 94  ? 13.367  17.753 -9.618  1.00 15.20 ? 94  GLN L CA  1 
ATOM   3020 C C   . GLN C 3 94  ? 12.328  18.740 -9.101  1.00 15.20 ? 94  GLN L C   1 
ATOM   3021 O O   . GLN C 3 94  ? 11.650  18.484 -8.097  1.00 14.52 ? 94  GLN L O   1 
ATOM   3022 C CB  . GLN C 3 94  ? 12.798  16.887 -10.755 1.00 15.46 ? 94  GLN L CB  1 
ATOM   3023 C CG  . GLN C 3 94  ? 11.569  16.054 -10.373 1.00 18.11 ? 94  GLN L CG  1 
ATOM   3024 C CD  . GLN C 3 94  ? 11.201  15.054 -11.447 1.00 20.14 ? 94  GLN L CD  1 
ATOM   3025 O OE1 . GLN C 3 94  ? 10.265  15.266 -12.215 1.00 25.37 ? 94  GLN L OE1 1 
ATOM   3026 N NE2 . GLN C 3 94  ? 11.948  13.960 -11.514 1.00 18.91 ? 94  GLN L NE2 1 
ATOM   3027 N N   . SER C 3 95  ? 12.218  19.894 -9.793  1.00 14.16 ? 95  SER L N   1 
ATOM   3028 C CA  . SER C 3 95  ? 11.157  20.831 -9.458  1.00 15.92 ? 95  SER L CA  1 
ATOM   3029 C C   . SER C 3 95  ? 9.849   20.398 -10.116 1.00 18.88 ? 95  SER L C   1 
ATOM   3030 O O   . SER C 3 95  ? 9.857   19.767 -11.184 1.00 15.89 ? 95  SER L O   1 
ATOM   3031 C CB  . SER C 3 95  ? 11.503  22.257 -9.892  1.00 18.66 ? 95  SER L CB  1 
ATOM   3032 O OG  . SER C 3 95  ? 11.667  22.360 -11.300 1.00 17.36 ? 95  SER L OG  1 
ATOM   3033 N N   . PRO C 3 96  ? 8.709   20.675 -9.468  1.00 15.89 ? 96  PRO L N   1 
ATOM   3034 C CA  . PRO C 3 96  ? 8.571   21.274 -8.131  1.00 13.36 ? 96  PRO L CA  1 
ATOM   3035 C C   . PRO C 3 96  ? 9.033   20.302 -7.028  1.00 13.65 ? 96  PRO L C   1 
ATOM   3036 O O   . PRO C 3 96  ? 8.757   19.096 -7.085  1.00 13.90 ? 96  PRO L O   1 
ATOM   3037 C CB  . PRO C 3 96  ? 7.069   21.585 -8.061  1.00 16.07 ? 96  PRO L CB  1 
ATOM   3038 C CG  . PRO C 3 96  ? 6.455   20.454 -8.844  1.00 16.86 ? 96  PRO L CG  1 
ATOM   3039 C CD  . PRO C 3 96  ? 7.407   20.223 -9.994  1.00 16.01 ? 96  PRO L CD  1 
ATOM   3040 N N   . TRP C 3 97  ? 9.790   20.806 -6.055  1.00 13.82 ? 97  TRP L N   1 
ATOM   3041 C CA  . TRP C 3 97  ? 10.100  20.039 -4.855  1.00 11.83 ? 97  TRP L CA  1 
ATOM   3042 C C   . TRP C 3 97  ? 8.810   19.727 -4.110  1.00 13.65 ? 97  TRP L C   1 
ATOM   3043 O O   . TRP C 3 97  ? 7.984   20.620 -3.897  1.00 11.90 ? 97  TRP L O   1 
ATOM   3044 C CB  . TRP C 3 97  ? 11.048  20.837 -3.952  1.00 12.69 ? 97  TRP L CB  1 
ATOM   3045 C CG  . TRP C 3 97  ? 12.473  20.908 -4.443  1.00 10.51 ? 97  TRP L CG  1 
ATOM   3046 C CD1 . TRP C 3 97  ? 13.522  20.134 -4.032  1.00 10.03 ? 97  TRP L CD1 1 
ATOM   3047 C CD2 . TRP C 3 97  ? 13.003  21.802 -5.429  1.00 9.87  ? 97  TRP L CD2 1 
ATOM   3048 N NE1 . TRP C 3 97  ? 14.665  20.496 -4.684  1.00 11.12 ? 97  TRP L NE1 1 
ATOM   3049 C CE2 . TRP C 3 97  ? 14.378  21.516 -5.551  1.00 12.01 ? 97  TRP L CE2 1 
ATOM   3050 C CE3 . TRP C 3 97  ? 12.450  22.822 -6.214  1.00 13.01 ? 97  TRP L CE3 1 
ATOM   3051 C CZ2 . TRP C 3 97  ? 15.206  22.197 -6.435  1.00 12.16 ? 97  TRP L CZ2 1 
ATOM   3052 C CZ3 . TRP C 3 97  ? 13.270  23.505 -7.091  1.00 12.61 ? 97  TRP L CZ3 1 
ATOM   3053 C CH2 . TRP C 3 97  ? 14.640  23.188 -7.192  1.00 12.19 ? 97  TRP L CH2 1 
ATOM   3054 N N   . THR C 3 98  ? 8.613   18.456 -3.741  1.00 12.11 ? 98  THR L N   1 
ATOM   3055 C CA  . THR C 3 98  ? 7.332   18.027 -3.193  1.00 11.25 ? 98  THR L CA  1 
ATOM   3056 C C   . THR C 3 98  ? 7.513   17.209 -1.924  1.00 10.91 ? 98  THR L C   1 
ATOM   3057 O O   . THR C 3 98  ? 8.518   16.509 -1.740  1.00 10.38 ? 98  THR L O   1 
ATOM   3058 C CB  . THR C 3 98  ? 6.488   17.220 -4.206  1.00 12.10 ? 98  THR L CB  1 
ATOM   3059 O OG1 . THR C 3 98  ? 7.262   16.144 -4.744  1.00 12.92 ? 98  THR L OG1 1 
ATOM   3060 C CG2 . THR C 3 98  ? 6.005   18.127 -5.338  1.00 12.74 ? 98  THR L CG2 1 
ATOM   3061 N N   . PHE C 3 99  ? 6.510   17.323 -1.048  1.00 10.25 ? 99  PHE L N   1 
ATOM   3062 C CA  . PHE C 3 99  ? 6.479   16.681 0.259   1.00 11.46 ? 99  PHE L CA  1 
ATOM   3063 C C   . PHE C 3 99  ? 5.306   15.716 0.354   1.00 11.91 ? 99  PHE L C   1 
ATOM   3064 O O   . PHE C 3 99  ? 4.250   15.923 -0.267  1.00 11.37 ? 99  PHE L O   1 
ATOM   3065 C CB  . PHE C 3 99  ? 6.335   17.707 1.392   1.00 10.37 ? 99  PHE L CB  1 
ATOM   3066 C CG  . PHE C 3 99  ? 7.472   18.652 1.498   1.00 10.74 ? 99  PHE L CG  1 
ATOM   3067 C CD1 . PHE C 3 99  ? 7.489   19.818 0.754   1.00 10.63 ? 99  PHE L CD1 1 
ATOM   3068 C CD2 . PHE C 3 99  ? 8.527   18.389 2.357   1.00 12.55 ? 99  PHE L CD2 1 
ATOM   3069 C CE1 . PHE C 3 99  ? 8.548   20.714 0.854   1.00 11.66 ? 99  PHE L CE1 1 
ATOM   3070 C CE2 . PHE C 3 99  ? 9.588   19.289 2.468   1.00 9.48  ? 99  PHE L CE2 1 
ATOM   3071 C CZ  . PHE C 3 99  ? 9.597   20.441 1.714   1.00 12.91 ? 99  PHE L CZ  1 
ATOM   3072 N N   . GLY C 3 100 ? 5.483   14.682 1.182   1.00 13.02 ? 100 GLY L N   1 
ATOM   3073 C CA  . GLY C 3 100 ? 4.353   13.907 1.648   1.00 13.19 ? 100 GLY L CA  1 
ATOM   3074 C C   . GLY C 3 100 ? 3.506   14.733 2.599   1.00 11.45 ? 100 GLY L C   1 
ATOM   3075 O O   . GLY C 3 100 ? 3.896   15.810 3.044   1.00 14.73 ? 100 GLY L O   1 
ATOM   3076 N N   . GLN C 3 101 ? 2.327   14.210 2.934   1.00 13.71 ? 101 GLN L N   1 
ATOM   3077 C CA  . GLN C 3 101 ? 1.382   14.956 3.759   1.00 13.84 ? 101 GLN L CA  1 
ATOM   3078 C C   . GLN C 3 101 ? 1.658   14.829 5.255   1.00 14.16 ? 101 GLN L C   1 
ATOM   3079 O O   . GLN C 3 101 ? 0.973   15.484 6.048   1.00 12.41 ? 101 GLN L O   1 
ATOM   3080 C CB  . GLN C 3 101 ? -0.062  14.521 3.445   1.00 16.19 ? 101 GLN L CB  1 
ATOM   3081 C CG  . GLN C 3 101 ? -0.552  13.255 4.182   1.00 17.32 ? 101 GLN L CG  1 
ATOM   3082 C CD  . GLN C 3 101 ? 0.049   11.944 3.680   1.00 18.54 ? 101 GLN L CD  1 
ATOM   3083 O OE1 . GLN C 3 101 ? 0.859   11.903 2.738   1.00 16.80 ? 101 GLN L OE1 1 
ATOM   3084 N NE2 . GLN C 3 101 ? -0.377  10.844 4.309   1.00 20.26 ? 101 GLN L NE2 1 
ATOM   3085 N N   . GLY C 3 102 ? 2.632   14.027 5.653   1.00 13.40 ? 102 GLY L N   1 
ATOM   3086 C CA  . GLY C 3 102 ? 3.093   13.963 7.027   1.00 13.52 ? 102 GLY L CA  1 
ATOM   3087 C C   . GLY C 3 102 ? 2.500   12.799 7.794   1.00 12.45 ? 102 GLY L C   1 
ATOM   3088 O O   . GLY C 3 102 ? 1.376   12.345 7.533   1.00 14.10 ? 102 GLY L O   1 
ATOM   3089 N N   . THR C 3 103 ? 3.271   12.305 8.763   1.00 13.64 ? 103 THR L N   1 
ATOM   3090 C CA  . THR C 3 103 ? 2.835   11.261 9.681   1.00 11.63 ? 103 THR L CA  1 
ATOM   3091 C C   . THR C 3 103 ? 3.046   11.750 11.103  1.00 11.70 ? 103 THR L C   1 
ATOM   3092 O O   . THR C 3 103 ? 4.154   12.172 11.453  1.00 13.13 ? 103 THR L O   1 
ATOM   3093 C CB  . THR C 3 103 ? 3.618   9.962  9.452   1.00 12.99 ? 103 THR L CB  1 
ATOM   3094 O OG1 . THR C 3 103 ? 3.196   9.347  8.227   1.00 12.44 ? 103 THR L OG1 1 
ATOM   3095 C CG2 . THR C 3 103 ? 3.403   9.001  10.593  1.00 12.69 ? 103 THR L CG2 1 
ATOM   3096 N N   . LYS C 3 104 ? 1.988   11.708 11.914  1.00 12.67 ? 104 LYS L N   1 
ATOM   3097 C CA  . LYS C 3 104 ? 2.107   12.087 13.313  1.00 14.69 ? 104 LYS L CA  1 
ATOM   3098 C C   . LYS C 3 104 ? 2.497   10.864 14.133  1.00 12.70 ? 104 LYS L C   1 
ATOM   3099 O O   . LYS C 3 104 ? 1.852   9.815  14.041  1.00 13.52 ? 104 LYS L O   1 
ATOM   3100 C CB  . LYS C 3 104 ? 0.801   12.685 13.827  1.00 14.63 ? 104 LYS L CB  1 
ATOM   3101 C CG  . LYS C 3 104 ? 0.879   13.172 15.273  1.00 15.16 ? 104 LYS L CG  1 
ATOM   3102 C CD  . LYS C 3 104 ? -0.487  13.616 15.725  1.00 16.54 ? 104 LYS L CD  1 
ATOM   3103 C CE  . LYS C 3 104 ? -0.409  14.250 17.087  1.00 20.49 ? 104 LYS L CE  1 
ATOM   3104 N NZ  . LYS C 3 104 ? -1.757  14.772 17.450  1.00 19.33 ? 104 LYS L NZ  1 
ATOM   3105 N N   . VAL C 3 105 ? 3.557   10.995 14.918  1.00 13.06 ? 105 VAL L N   1 
ATOM   3106 C CA  . VAL C 3 105 ? 3.941   9.977  15.889  1.00 13.47 ? 105 VAL L CA  1 
ATOM   3107 C C   . VAL C 3 105 ? 3.532   10.521 17.251  1.00 14.54 ? 105 VAL L C   1 
ATOM   3108 O O   . VAL C 3 105 ? 4.119   11.495 17.735  1.00 16.00 ? 105 VAL L O   1 
ATOM   3109 C CB  . VAL C 3 105 ? 5.440   9.650  15.833  1.00 14.31 ? 105 VAL L CB  1 
ATOM   3110 C CG1 . VAL C 3 105 ? 5.775   8.603  16.863  1.00 13.15 ? 105 VAL L CG1 1 
ATOM   3111 C CG2 . VAL C 3 105 ? 5.833   9.138  14.454  1.00 11.57 ? 105 VAL L CG2 1 
ATOM   3112 N N   . GLU C 3 106 ? 2.506   9.914  17.853  1.00 15.31 ? 106 GLU L N   1 
ATOM   3113 C CA  . GLU C 3 106 ? 1.886   10.376 19.090  1.00 15.16 ? 106 GLU L CA  1 
ATOM   3114 C C   . GLU C 3 106 ? 2.112   9.358  20.200  1.00 15.33 ? 106 GLU L C   1 
ATOM   3115 O O   . GLU C 3 106 ? 2.419   8.195  19.949  1.00 16.18 ? 106 GLU L O   1 
ATOM   3116 C CB  . GLU C 3 106 ? 0.366   10.608 18.930  1.00 16.56 ? 106 GLU L CB  1 
ATOM   3117 C CG  . GLU C 3 106 ? -0.422  9.323  18.774  1.00 18.59 ? 106 GLU L CG  1 
ATOM   3118 C CD  . GLU C 3 106 ? -1.894  9.420  19.151  1.00 20.11 ? 106 GLU L CD  1 
ATOM   3119 O OE1 . GLU C 3 106 ? -2.432  10.522 19.390  1.00 20.20 ? 106 GLU L OE1 1 
ATOM   3120 O OE2 . GLU C 3 106 ? -2.538  8.357  19.195  1.00 21.20 ? 106 GLU L OE2 1 
ATOM   3121 N N   . ILE C 3 107 ? 1.934   9.804  21.439  1.00 16.98 ? 107 ILE L N   1 
ATOM   3122 C CA  . ILE C 3 107 ? 2.048   8.908  22.588  1.00 18.76 ? 107 ILE L CA  1 
ATOM   3123 C C   . ILE C 3 107 ? 0.807   8.027  22.678  1.00 18.09 ? 107 ILE L C   1 
ATOM   3124 O O   . ILE C 3 107 ? -0.326  8.526  22.734  1.00 17.12 ? 107 ILE L O   1 
ATOM   3125 C CB  . ILE C 3 107 ? 2.239   9.706  23.886  1.00 17.88 ? 107 ILE L CB  1 
ATOM   3126 C CG1 . ILE C 3 107 ? 3.492   10.581 23.807  1.00 20.92 ? 107 ILE L CG1 1 
ATOM   3127 C CG2 . ILE C 3 107 ? 2.261   8.741  25.082  1.00 18.92 ? 107 ILE L CG2 1 
ATOM   3128 C CD1 . ILE C 3 107 ? 4.714   9.947  24.400  1.00 26.37 ? 107 ILE L CD1 1 
ATOM   3129 N N   . LYS C 3 108 ? 1.008   6.710  22.720  1.00 17.33 ? 108 LYS L N   1 
ATOM   3130 C CA  . LYS C 3 108 ? -0.120  5.822  22.976  1.00 17.99 ? 108 LYS L CA  1 
ATOM   3131 C C   . LYS C 3 108 ? -0.408  5.735  24.471  1.00 16.33 ? 108 LYS L C   1 
ATOM   3132 O O   . LYS C 3 108 ? 0.500   5.770  25.304  1.00 19.33 ? 108 LYS L O   1 
ATOM   3133 C CB  . LYS C 3 108 ? 0.133   4.414  22.422  1.00 22.17 ? 108 LYS L CB  1 
ATOM   3134 C CG  . LYS C 3 108 ? -1.076  3.475  22.587  1.00 17.54 ? 108 LYS L CG  1 
ATOM   3135 C CD  . LYS C 3 108 ? -1.302  2.620  21.358  1.00 27.47 ? 108 LYS L CD  1 
ATOM   3136 C CE  . LYS C 3 108 ? -2.233  1.453  21.657  1.00 29.98 ? 108 LYS L CE  1 
ATOM   3137 N NZ  . LYS C 3 108 ? -2.038  0.311  20.704  1.00 34.08 ? 108 LYS L NZ  1 
ATOM   3138 N N   . ARG C 3 109 ? -1.693  5.655  24.800  1.00 14.26 ? 109 ARG L N   1 
ATOM   3139 C CA  . ARG C 3 109 ? -2.150  5.392  26.155  1.00 14.55 ? 109 ARG L CA  1 
ATOM   3140 C C   . ARG C 3 109 ? -3.401  4.535  26.057  1.00 14.43 ? 109 ARG L C   1 
ATOM   3141 O O   . ARG C 3 109 ? -3.889  4.242  24.964  1.00 13.56 ? 109 ARG L O   1 
ATOM   3142 C CB  . ARG C 3 109 ? -2.435  6.690  26.909  1.00 13.83 ? 109 ARG L CB  1 
ATOM   3143 C CG  . ARG C 3 109 ? -3.473  7.577  26.221  1.00 12.60 ? 109 ARG L CG  1 
ATOM   3144 C CD  . ARG C 3 109 ? -4.228  8.396  27.255  1.00 14.93 ? 109 ARG L CD  1 
ATOM   3145 N NE  . ARG C 3 109 ? -5.000  7.496  28.108  1.00 13.65 ? 109 ARG L NE  1 
ATOM   3146 C CZ  . ARG C 3 109 ? -5.324  7.750  29.365  1.00 17.08 ? 109 ARG L CZ  1 
ATOM   3147 N NH1 . ARG C 3 109 ? -4.974  8.880  29.952  1.00 15.31 ? 109 ARG L NH1 1 
ATOM   3148 N NH2 . ARG C 3 109 ? -6.013  6.844  30.052  1.00 15.44 ? 109 ARG L NH2 1 
ATOM   3149 N N   . THR C 3 110 ? -3.935  4.138  27.207  1.00 15.77 ? 110 THR L N   1 
ATOM   3150 C CA  . THR C 3 110 ? -5.147  3.330  27.168  1.00 15.15 ? 110 THR L CA  1 
ATOM   3151 C C   . THR C 3 110 ? -6.333  4.170  26.715  1.00 14.84 ? 110 THR L C   1 
ATOM   3152 O O   . THR C 3 110 ? -6.343  5.405  26.835  1.00 15.10 ? 110 THR L O   1 
ATOM   3153 C CB  . THR C 3 110 ? -5.449  2.707  28.531  1.00 17.60 ? 110 THR L CB  1 
ATOM   3154 O OG1 . THR C 3 110 ? -5.593  3.743  29.510  1.00 16.94 ? 110 THR L OG1 1 
ATOM   3155 C CG2 . THR C 3 110 ? -4.331  1.794  28.932  1.00 18.87 ? 110 THR L CG2 1 
ATOM   3156 N N   . VAL C 3 111 ? -7.326  3.483  26.144  1.00 15.09 ? 111 VAL L N   1 
ATOM   3157 C CA  . VAL C 3 111 ? -8.549  4.149  25.707  1.00 15.90 ? 111 VAL L CA  1 
ATOM   3158 C C   . VAL C 3 111 ? -9.199  4.853  26.896  1.00 17.59 ? 111 VAL L C   1 
ATOM   3159 O O   . VAL C 3 111 ? -9.218  4.332  28.023  1.00 13.96 ? 111 VAL L O   1 
ATOM   3160 C CB  . VAL C 3 111 ? -9.505  3.135  25.052  1.00 16.15 ? 111 VAL L CB  1 
ATOM   3161 C CG1 . VAL C 3 111 ? -10.852 3.765  24.758  1.00 17.27 ? 111 VAL L CG1 1 
ATOM   3162 C CG2 . VAL C 3 111 ? -8.907  2.573  23.757  1.00 17.01 ? 111 VAL L CG2 1 
ATOM   3163 N N   . ALA C 3 112 ? -9.701  6.064  26.659  1.00 14.66 ? 112 ALA L N   1 
ATOM   3164 C CA  . ALA C 3 112 ? -10.404 6.830  27.685  1.00 14.82 ? 112 ALA L CA  1 
ATOM   3165 C C   . ALA C 3 112 ? -11.580 7.525  27.028  1.00 15.12 ? 112 ALA L C   1 
ATOM   3166 O O   . ALA C 3 112 ? -11.396 8.295  26.075  1.00 14.17 ? 112 ALA L O   1 
ATOM   3167 C CB  . ALA C 3 112 ? -9.479  7.844  28.362  1.00 15.01 ? 112 ALA L CB  1 
ATOM   3168 N N   . ALA C 3 113 ? -12.784 7.234  27.506  1.00 14.77 ? 113 ALA L N   1 
ATOM   3169 C CA  . ALA C 3 113 ? -13.954 7.891  26.960  1.00 16.74 ? 113 ALA L CA  1 
ATOM   3170 C C   . ALA C 3 113 ? -13.945 9.364  27.362  1.00 12.93 ? 113 ALA L C   1 
ATOM   3171 O O   . ALA C 3 113 ? -13.434 9.725  28.426  1.00 15.57 ? 113 ALA L O   1 
ATOM   3172 C CB  . ALA C 3 113 ? -15.240 7.228  27.456  1.00 17.69 ? 113 ALA L CB  1 
ATOM   3173 N N   . PRO C 3 114 ? -14.471 10.236 26.518  1.00 15.70 ? 114 PRO L N   1 
ATOM   3174 C CA  . PRO C 3 114 ? -14.593 11.642 26.916  1.00 15.80 ? 114 PRO L CA  1 
ATOM   3175 C C   . PRO C 3 114 ? -15.680 11.826 27.965  1.00 18.43 ? 114 PRO L C   1 
ATOM   3176 O O   . PRO C 3 114 ? -16.686 11.110 27.985  1.00 18.06 ? 114 PRO L O   1 
ATOM   3177 C CB  . PRO C 3 114 ? -14.961 12.347 25.608  1.00 16.16 ? 114 PRO L CB  1 
ATOM   3178 C CG  . PRO C 3 114 ? -15.582 11.278 24.769  1.00 18.15 ? 114 PRO L CG  1 
ATOM   3179 C CD  . PRO C 3 114 ? -14.903 10.000 25.129  1.00 15.52 ? 114 PRO L CD  1 
ATOM   3180 N N   . SER C 3 115 ? -15.445 12.764 28.879  1.00 19.97 ? 115 SER L N   1 
ATOM   3181 C CA  . SER C 3 115 ? -16.539 13.352 29.635  1.00 17.25 ? 115 SER L CA  1 
ATOM   3182 C C   . SER C 3 115 ? -17.148 14.446 28.773  1.00 17.31 ? 115 SER L C   1 
ATOM   3183 O O   . SER C 3 115 ? -16.427 15.305 28.256  1.00 19.64 ? 115 SER L O   1 
ATOM   3184 C CB  . SER C 3 115 ? -16.049 13.932 30.958  1.00 20.39 ? 115 SER L CB  1 
ATOM   3185 O OG  . SER C 3 115 ? -15.780 12.898 31.882  1.00 28.50 ? 115 SER L OG  1 
ATOM   3186 N N   . VAL C 3 116 ? -18.463 14.418 28.601  1.00 17.41 ? 116 VAL L N   1 
ATOM   3187 C CA  . VAL C 3 116 ? -19.140 15.338 27.694  1.00 18.30 ? 116 VAL L CA  1 
ATOM   3188 C C   . VAL C 3 116 ? -19.983 16.319 28.494  1.00 18.89 ? 116 VAL L C   1 
ATOM   3189 O O   . VAL C 3 116 ? -20.698 15.933 29.425  1.00 14.70 ? 116 VAL L O   1 
ATOM   3190 C CB  . VAL C 3 116 ? -20.000 14.580 26.666  1.00 20.00 ? 116 VAL L CB  1 
ATOM   3191 C CG1 . VAL C 3 116 ? -20.572 15.563 25.647  1.00 20.42 ? 116 VAL L CG1 1 
ATOM   3192 C CG2 . VAL C 3 116 ? -19.149 13.503 25.967  1.00 19.50 ? 116 VAL L CG2 1 
ATOM   3193 N N   . PHE C 3 117 ? -19.899 17.593 28.124  1.00 16.68 ? 117 PHE L N   1 
ATOM   3194 C CA  . PHE C 3 117 ? -20.676 18.649 28.753  1.00 17.31 ? 117 PHE L CA  1 
ATOM   3195 C C   . PHE C 3 117 ? -21.259 19.508 27.640  1.00 17.72 ? 117 PHE L C   1 
ATOM   3196 O O   . PHE C 3 117 ? -20.607 19.713 26.619  1.00 15.80 ? 117 PHE L O   1 
ATOM   3197 C CB  . PHE C 3 117 ? -19.804 19.493 29.697  1.00 16.43 ? 117 PHE L CB  1 
ATOM   3198 C CG  . PHE C 3 117 ? -19.044 18.682 30.725  1.00 18.64 ? 117 PHE L CG  1 
ATOM   3199 C CD1 . PHE C 3 117 ? -19.555 18.513 32.013  1.00 17.29 ? 117 PHE L CD1 1 
ATOM   3200 C CD2 . PHE C 3 117 ? -17.804 18.116 30.418  1.00 16.18 ? 117 PHE L CD2 1 
ATOM   3201 C CE1 . PHE C 3 117 ? -18.850 17.773 32.971  1.00 17.91 ? 117 PHE L CE1 1 
ATOM   3202 C CE2 . PHE C 3 117 ? -17.101 17.380 31.361  1.00 15.78 ? 117 PHE L CE2 1 
ATOM   3203 C CZ  . PHE C 3 117 ? -17.627 17.209 32.646  1.00 19.70 ? 117 PHE L CZ  1 
ATOM   3204 N N   . ILE C 3 118 ? -22.493 19.976 27.813  1.00 18.42 ? 118 ILE L N   1 
ATOM   3205 C CA  . ILE C 3 118 ? -23.113 20.897 26.869  1.00 16.90 ? 118 ILE L CA  1 
ATOM   3206 C C   . ILE C 3 118 ? -23.410 22.209 27.585  1.00 19.97 ? 118 ILE L C   1 
ATOM   3207 O O   . ILE C 3 118 ? -23.820 22.224 28.752  1.00 18.22 ? 118 ILE L O   1 
ATOM   3208 C CB  . ILE C 3 118 ? -24.382 20.297 26.230  1.00 17.37 ? 118 ILE L CB  1 
ATOM   3209 C CG1 . ILE C 3 118 ? -24.879 21.185 25.094  1.00 19.37 ? 118 ILE L CG1 1 
ATOM   3210 C CG2 . ILE C 3 118 ? -25.488 20.106 27.256  1.00 18.74 ? 118 ILE L CG2 1 
ATOM   3211 C CD1 . ILE C 3 118 ? -26.083 20.605 24.383  1.00 20.32 ? 118 ILE L CD1 1 
ATOM   3212 N N   . PHE C 3 119 ? -23.182 23.315 26.885  1.00 17.15 ? 119 PHE L N   1 
ATOM   3213 C CA  . PHE C 3 119 ? -23.305 24.648 27.460  1.00 17.14 ? 119 PHE L CA  1 
ATOM   3214 C C   . PHE C 3 119 ? -24.319 25.449 26.662  1.00 17.88 ? 119 PHE L C   1 
ATOM   3215 O O   . PHE C 3 119 ? -24.147 25.608 25.439  1.00 16.43 ? 119 PHE L O   1 
ATOM   3216 C CB  . PHE C 3 119 ? -21.964 25.372 27.452  1.00 18.40 ? 119 PHE L CB  1 
ATOM   3217 C CG  . PHE C 3 119 ? -20.904 24.716 28.290  1.00 17.25 ? 119 PHE L CG  1 
ATOM   3218 C CD1 . PHE C 3 119 ? -20.942 24.814 29.671  1.00 17.81 ? 119 PHE L CD1 1 
ATOM   3219 C CD2 . PHE C 3 119 ? -19.844 24.049 27.690  1.00 18.80 ? 119 PHE L CD2 1 
ATOM   3220 C CE1 . PHE C 3 119 ? -19.956 24.237 30.445  1.00 19.00 ? 119 PHE L CE1 1 
ATOM   3221 C CE2 . PHE C 3 119 ? -18.845 23.462 28.459  1.00 18.84 ? 119 PHE L CE2 1 
ATOM   3222 C CZ  . PHE C 3 119 ? -18.903 23.563 29.837  1.00 17.28 ? 119 PHE L CZ  1 
ATOM   3223 N N   . PRO C 3 120 ? -25.364 25.986 27.282  1.00 19.81 ? 120 PRO L N   1 
ATOM   3224 C CA  . PRO C 3 120 ? -26.297 26.822 26.544  1.00 18.83 ? 120 PRO L CA  1 
ATOM   3225 C C   . PRO C 3 120 ? -25.697 28.192 26.296  1.00 16.49 ? 120 PRO L C   1 
ATOM   3226 O O   . PRO C 3 120 ? -24.779 28.619 27.018  1.00 20.55 ? 120 PRO L O   1 
ATOM   3227 C CB  . PRO C 3 120 ? -27.510 26.903 27.483  1.00 18.37 ? 120 PRO L CB  1 
ATOM   3228 C CG  . PRO C 3 120 ? -26.894 26.846 28.843  1.00 25.68 ? 120 PRO L CG  1 
ATOM   3229 C CD  . PRO C 3 120 ? -25.691 25.922 28.719  1.00 20.87 ? 120 PRO L CD  1 
ATOM   3230 N N   . PRO C 3 121 ? -26.185 28.920 25.297  1.00 16.34 ? 121 PRO L N   1 
ATOM   3231 C CA  . PRO C 3 121 ? -25.739 30.309 25.127  1.00 20.10 ? 121 PRO L CA  1 
ATOM   3232 C C   . PRO C 3 121 ? -26.081 31.131 26.362  1.00 20.87 ? 121 PRO L C   1 
ATOM   3233 O O   . PRO C 3 121 ? -27.096 30.900 27.026  1.00 20.49 ? 121 PRO L O   1 
ATOM   3234 C CB  . PRO C 3 121 ? -26.506 30.797 23.889  1.00 21.00 ? 121 PRO L CB  1 
ATOM   3235 C CG  . PRO C 3 121 ? -27.209 29.595 23.318  1.00 21.14 ? 121 PRO L CG  1 
ATOM   3236 C CD  . PRO C 3 121 ? -27.281 28.553 24.385  1.00 17.40 ? 121 PRO L CD  1 
ATOM   3237 N N   . SER C 3 122 ? -25.213 32.084 26.680  1.00 19.95 ? 122 SER L N   1 
ATOM   3238 C CA  . SER C 3 122 ? -25.489 32.986 27.784  1.00 20.44 ? 122 SER L CA  1 
ATOM   3239 C C   . SER C 3 122 ? -26.587 33.963 27.391  1.00 24.25 ? 122 SER L C   1 
ATOM   3240 O O   . SER C 3 122 ? -26.787 34.262 26.213  1.00 21.98 ? 122 SER L O   1 
ATOM   3241 C CB  . SER C 3 122 ? -24.233 33.751 28.178  1.00 20.64 ? 122 SER L CB  1 
ATOM   3242 O OG  . SER C 3 122 ? -23.789 34.565 27.096  1.00 17.30 ? 122 SER L OG  1 
ATOM   3243 N N   . ASP C 3 123 ? -27.313 34.459 28.397  1.00 26.99 ? 123 ASP L N   1 
ATOM   3244 C CA  . ASP C 3 123 ? -28.299 35.500 28.125  1.00 27.74 ? 123 ASP L CA  1 
ATOM   3245 C C   . ASP C 3 123 ? -27.624 36.757 27.604  1.00 25.99 ? 123 ASP L C   1 
ATOM   3246 O O   . ASP C 3 123 ? -28.132 37.405 26.681  1.00 27.02 ? 123 ASP L O   1 
ATOM   3247 C CB  . ASP C 3 123 ? -29.113 35.803 29.386  1.00 30.61 ? 123 ASP L CB  1 
ATOM   3248 C CG  . ASP C 3 123 ? -30.179 34.759 29.655  1.00 30.76 ? 123 ASP L CG  1 
ATOM   3249 O OD1 . ASP C 3 123 ? -30.322 33.826 28.836  1.00 34.26 ? 123 ASP L OD1 1 
ATOM   3250 O OD2 . ASP C 3 123 ? -30.875 34.876 30.682  1.00 38.74 ? 123 ASP L OD2 1 
ATOM   3251 N N   . GLU C 3 124 ? -26.469 37.103 28.176  1.00 25.14 ? 124 GLU L N   1 
ATOM   3252 C CA  . GLU C 3 124 ? -25.674 38.221 27.682  1.00 24.61 ? 124 GLU L CA  1 
ATOM   3253 C C   . GLU C 3 124 ? -25.467 38.124 26.174  1.00 26.62 ? 124 GLU L C   1 
ATOM   3254 O O   . GLU C 3 124 ? -25.707 39.086 25.437  1.00 24.22 ? 124 GLU L O   1 
ATOM   3255 C CB  . GLU C 3 124 ? -24.333 38.249 28.421  1.00 23.59 ? 124 GLU L CB  1 
ATOM   3256 C CG  . GLU C 3 124 ? -23.455 39.456 28.136  1.00 26.39 ? 124 GLU L CG  1 
ATOM   3257 C CD  . GLU C 3 124 ? -22.146 39.422 28.921  1.00 31.98 ? 124 GLU L CD  1 
ATOM   3258 N N   . GLN C 3 125 ? -25.049 36.951 25.692  1.00 22.75 ? 125 GLN L N   1 
ATOM   3259 C CA  . GLN C 3 125 ? -24.787 36.811 24.265  1.00 22.32 ? 125 GLN L CA  1 
ATOM   3260 C C   . GLN C 3 125 ? -26.057 37.001 23.445  1.00 24.00 ? 125 GLN L C   1 
ATOM   3261 O O   . GLN C 3 125 ? -26.020 37.604 22.370  1.00 25.85 ? 125 GLN L O   1 
ATOM   3262 C CB  . GLN C 3 125 ? -24.157 35.452 23.955  1.00 18.95 ? 125 GLN L CB  1 
ATOM   3263 C CG  . GLN C 3 125 ? -23.762 35.355 22.481  1.00 19.62 ? 125 GLN L CG  1 
ATOM   3264 C CD  . GLN C 3 125 ? -23.233 33.997 22.067  1.00 19.88 ? 125 GLN L CD  1 
ATOM   3265 O OE1 . GLN C 3 125 ? -23.496 32.981 22.713  1.00 15.43 ? 125 GLN L OE1 1 
ATOM   3266 N NE2 . GLN C 3 125 ? -22.481 33.974 20.972  1.00 16.04 ? 125 GLN L NE2 1 
ATOM   3267 N N   . LEU C 3 126 ? -27.191 36.492 23.932  1.00 27.36 ? 126 LEU L N   1 
ATOM   3268 C CA  . LEU C 3 126 ? -28.416 36.558 23.135  1.00 27.23 ? 126 LEU L CA  1 
ATOM   3269 C C   . LEU C 3 126 ? -28.828 37.994 22.831  1.00 30.62 ? 126 LEU L C   1 
ATOM   3270 O O   . LEU C 3 126 ? -29.441 38.248 21.789  1.00 32.02 ? 126 LEU L O   1 
ATOM   3271 C CB  . LEU C 3 126 ? -29.540 35.812 23.837  1.00 25.94 ? 126 LEU L CB  1 
ATOM   3272 C CG  . LEU C 3 126 ? -29.277 34.308 23.837  1.00 26.35 ? 126 LEU L CG  1 
ATOM   3273 C CD1 . LEU C 3 126 ? -30.210 33.600 24.790  1.00 27.99 ? 126 LEU L CD1 1 
ATOM   3274 C CD2 . LEU C 3 126 ? -29.439 33.781 22.424  1.00 26.25 ? 126 LEU L CD2 1 
ATOM   3275 N N   . LYS C 3 127 ? -28.472 38.947 23.701  1.00 32.03 ? 127 LYS L N   1 
ATOM   3276 C CA  . LYS C 3 127 ? -28.737 40.356 23.412  1.00 32.59 ? 127 LYS L CA  1 
ATOM   3277 C C   . LYS C 3 127 ? -28.081 40.803 22.111  1.00 33.39 ? 127 LYS L C   1 
ATOM   3278 O O   . LYS C 3 127 ? -28.582 41.720 21.450  1.00 37.45 ? 127 LYS L O   1 
ATOM   3279 C CB  . LYS C 3 127 ? -28.250 41.242 24.561  1.00 31.95 ? 127 LYS L CB  1 
ATOM   3280 C CG  . LYS C 3 127 ? -28.973 41.048 25.889  1.00 36.20 ? 127 LYS L CG  1 
ATOM   3281 C CD  . LYS C 3 127 ? -28.451 42.027 26.955  1.00 34.96 ? 127 LYS L CD  1 
ATOM   3282 C CE  . LYS C 3 127 ? -29.117 41.801 28.322  1.00 44.93 ? 127 LYS L CE  1 
ATOM   3283 N NZ  . LYS C 3 127 ? -30.533 42.292 28.394  1.00 51.09 ? 127 LYS L NZ  1 
ATOM   3284 N N   . SER C 3 128 ? -26.967 40.180 21.726  1.00 32.63 ? 128 SER L N   1 
ATOM   3285 C CA  . SER C 3 128 ? -26.281 40.521 20.485  1.00 32.05 ? 128 SER L CA  1 
ATOM   3286 C C   . SER C 3 128 ? -26.924 39.897 19.250  1.00 31.97 ? 128 SER L C   1 
ATOM   3287 O O   . SER C 3 128 ? -26.483 40.196 18.130  1.00 31.22 ? 128 SER L O   1 
ATOM   3288 C CB  . SER C 3 128 ? -24.809 40.103 20.568  1.00 32.27 ? 128 SER L CB  1 
ATOM   3289 O OG  . SER C 3 128 ? -24.665 38.694 20.438  1.00 30.51 ? 128 SER L OG  1 
ATOM   3290 N N   . GLY C 3 129 ? -27.936 39.045 19.420  1.00 27.76 ? 129 GLY L N   1 
ATOM   3291 C CA  . GLY C 3 129 ? -28.625 38.436 18.300  1.00 27.25 ? 129 GLY L CA  1 
ATOM   3292 C C   . GLY C 3 129 ? -28.072 37.105 17.845  1.00 28.12 ? 129 GLY L C   1 
ATOM   3293 O O   . GLY C 3 129 ? -28.499 36.597 16.795  1.00 24.18 ? 129 GLY L O   1 
ATOM   3294 N N   . THR C 3 130 ? -27.133 36.525 18.595  1.00 26.51 ? 130 THR L N   1 
ATOM   3295 C CA  . THR C 3 130 ? -26.458 35.291 18.215  1.00 21.51 ? 130 THR L CA  1 
ATOM   3296 C C   . THR C 3 130 ? -26.408 34.363 19.412  1.00 21.70 ? 130 THR L C   1 
ATOM   3297 O O   . THR C 3 130 ? -26.258 34.817 20.551  1.00 23.17 ? 130 THR L O   1 
ATOM   3298 C CB  . THR C 3 130 ? -25.041 35.574 17.704  1.00 22.35 ? 130 THR L CB  1 
ATOM   3299 O OG1 . THR C 3 130 ? -25.105 36.513 16.630  1.00 24.94 ? 130 THR L OG1 1 
ATOM   3300 C CG2 . THR C 3 130 ? -24.382 34.305 17.188  1.00 22.03 ? 130 THR L CG2 1 
ATOM   3301 N N   . ALA C 3 131 ? -26.558 33.066 19.150  1.00 21.15 ? 131 ALA L N   1 
ATOM   3302 C CA  . ALA C 3 131 ? -26.486 32.033 20.175  1.00 21.95 ? 131 ALA L CA  1 
ATOM   3303 C C   . ALA C 3 131 ? -25.348 31.082 19.828  1.00 21.98 ? 131 ALA L C   1 
ATOM   3304 O O   . ALA C 3 131 ? -25.362 30.442 18.767  1.00 19.73 ? 131 ALA L O   1 
ATOM   3305 C CB  . ALA C 3 131 ? -27.816 31.277 20.289  1.00 21.43 ? 131 ALA L CB  1 
ATOM   3306 N N   . SER C 3 132 ? -24.362 30.997 20.708  1.00 17.96 ? 132 SER L N   1 
ATOM   3307 C CA  . SER C 3 132 ? -23.307 30.002 20.581  1.00 16.46 ? 132 SER L CA  1 
ATOM   3308 C C   . SER C 3 132 ? -23.602 28.875 21.564  1.00 14.67 ? 132 SER L C   1 
ATOM   3309 O O   . SER C 3 132 ? -23.724 29.121 22.770  1.00 17.49 ? 132 SER L O   1 
ATOM   3310 C CB  . SER C 3 132 ? -21.931 30.617 20.840  1.00 17.55 ? 132 SER L CB  1 
ATOM   3311 O OG  . SER C 3 132 ? -21.637 31.654 19.919  1.00 16.93 ? 132 SER L OG  1 
ATOM   3312 N N   . VAL C 3 133 ? -23.730 27.652 21.050  1.00 15.73 ? 133 VAL L N   1 
ATOM   3313 C CA  . VAL C 3 133 ? -23.920 26.457 21.869  1.00 15.12 ? 133 VAL L CA  1 
ATOM   3314 C C   . VAL C 3 133 ? -22.645 25.629 21.791  1.00 15.53 ? 133 VAL L C   1 
ATOM   3315 O O   . VAL C 3 133 ? -22.179 25.300 20.691  1.00 16.39 ? 133 VAL L O   1 
ATOM   3316 C CB  . VAL C 3 133 ? -25.136 25.630 21.414  1.00 17.63 ? 133 VAL L CB  1 
ATOM   3317 C CG1 . VAL C 3 133 ? -25.568 24.687 22.527  1.00 16.95 ? 133 VAL L CG1 1 
ATOM   3318 C CG2 . VAL C 3 133 ? -26.288 26.555 20.992  1.00 16.34 ? 133 VAL L CG2 1 
ATOM   3319 N N   . VAL C 3 134 ? -22.094 25.275 22.952  1.00 15.14 ? 134 VAL L N   1 
ATOM   3320 C CA  . VAL C 3 134 ? -20.764 24.670 23.041  1.00 14.23 ? 134 VAL L CA  1 
ATOM   3321 C C   . VAL C 3 134 ? -20.892 23.266 23.613  1.00 15.98 ? 134 VAL L C   1 
ATOM   3322 O O   . VAL C 3 134 ? -21.564 23.059 24.627  1.00 13.97 ? 134 VAL L O   1 
ATOM   3323 C CB  . VAL C 3 134 ? -19.808 25.519 23.904  1.00 16.34 ? 134 VAL L CB  1 
ATOM   3324 C CG1 . VAL C 3 134 ? -18.443 24.808 24.079  1.00 14.37 ? 134 VAL L CG1 1 
ATOM   3325 C CG2 . VAL C 3 134 ? -19.621 26.917 23.288  1.00 17.44 ? 134 VAL L CG2 1 
ATOM   3326 N N   . CYS C 3 135 ? -20.218 22.310 22.984  1.00 15.99 ? 135 CYS L N   1 
ATOM   3327 C CA  . CYS C 3 135 ? -20.135 20.952 23.498  1.00 14.98 ? 135 CYS L CA  1 
ATOM   3328 C C   . CYS C 3 135 ? -18.675 20.613 23.754  1.00 13.94 ? 135 CYS L C   1 
ATOM   3329 O O   . CYS C 3 135 ? -17.831 20.786 22.868  1.00 18.20 ? 135 CYS L O   1 
ATOM   3330 C CB  . CYS C 3 135 ? -20.751 19.971 22.519  1.00 13.81 ? 135 CYS L CB  1 
ATOM   3331 S SG  . CYS C 3 135 ? -20.876 18.312 23.146  1.00 21.93 ? 135 CYS L SG  1 
ATOM   3332 N N   . LEU C 3 136 ? -18.376 20.153 24.964  1.00 13.91 ? 136 LEU L N   1 
ATOM   3333 C CA  . LEU C 3 136 ? -17.009 19.879 25.388  1.00 11.60 ? 136 LEU L CA  1 
ATOM   3334 C C   . LEU C 3 136 ? -16.809 18.376 25.552  1.00 13.93 ? 136 LEU L C   1 
ATOM   3335 O O   . LEU C 3 136 ? -17.562 17.728 26.284  1.00 15.31 ? 136 LEU L O   1 
ATOM   3336 C CB  . LEU C 3 136 ? -16.702 20.594 26.706  1.00 15.36 ? 136 LEU L CB  1 
ATOM   3337 C CG  . LEU C 3 136 ? -15.431 20.151 27.440  1.00 12.71 ? 136 LEU L CG  1 
ATOM   3338 C CD1 . LEU C 3 136 ? -14.180 20.534 26.650  1.00 12.00 ? 136 LEU L CD1 1 
ATOM   3339 C CD2 . LEU C 3 136 ? -15.376 20.720 28.858  1.00 16.03 ? 136 LEU L CD2 1 
ATOM   3340 N N   . LEU C 3 137 ? -15.808 17.823 24.868  1.00 13.35 ? 137 LEU L N   1 
ATOM   3341 C CA  . LEU C 3 137 ? -15.378 16.440 25.079  1.00 15.65 ? 137 LEU L CA  1 
ATOM   3342 C C   . LEU C 3 137 ? -14.035 16.505 25.790  1.00 14.61 ? 137 LEU L C   1 
ATOM   3343 O O   . LEU C 3 137 ? -13.047 16.981 25.223  1.00 16.46 ? 137 LEU L O   1 
ATOM   3344 C CB  . LEU C 3 137 ? -15.246 15.642 23.788  1.00 14.97 ? 137 LEU L CB  1 
ATOM   3345 C CG  . LEU C 3 137 ? -16.122 15.790 22.552  1.00 23.62 ? 137 LEU L CG  1 
ATOM   3346 C CD1 . LEU C 3 137 ? -16.081 14.482 21.785  1.00 19.43 ? 137 LEU L CD1 1 
ATOM   3347 C CD2 . LEU C 3 137 ? -17.549 16.272 22.794  1.00 18.88 ? 137 LEU L CD2 1 
ATOM   3348 N N   . ASN C 3 138 ? -13.999 16.054 27.031  1.00 13.26 ? 138 ASN L N   1 
ATOM   3349 C CA  . ASN C 3 138 ? -12.861 16.300 27.902  1.00 15.54 ? 138 ASN L CA  1 
ATOM   3350 C C   . ASN C 3 138 ? -12.060 15.024 28.135  1.00 17.01 ? 138 ASN L C   1 
ATOM   3351 O O   . ASN C 3 138 ? -12.625 13.986 28.501  1.00 16.32 ? 138 ASN L O   1 
ATOM   3352 C CB  . ASN C 3 138 ? -13.334 16.872 29.235  1.00 16.90 ? 138 ASN L CB  1 
ATOM   3353 C CG  . ASN C 3 138 ? -12.231 17.581 29.976  1.00 16.98 ? 138 ASN L CG  1 
ATOM   3354 O OD1 . ASN C 3 138 ? -11.559 18.445 29.419  1.00 20.33 ? 138 ASN L OD1 1 
ATOM   3355 N ND2 . ASN C 3 138 ? -12.020 17.205 31.226  1.00 22.88 ? 138 ASN L ND2 1 
ATOM   3356 N N   . ASN C 3 139 ? -10.745 15.115 27.922  1.00 15.44 ? 139 ASN L N   1 
ATOM   3357 C CA  . ASN C 3 139 ? -9.759  14.103 28.323  1.00 14.35 ? 139 ASN L CA  1 
ATOM   3358 C C   . ASN C 3 139 ? -10.079 12.719 27.745  1.00 15.08 ? 139 ASN L C   1 
ATOM   3359 O O   . ASN C 3 139 ? -10.321 11.750 28.471  1.00 14.57 ? 139 ASN L O   1 
ATOM   3360 C CB  . ASN C 3 139 ? -9.646  14.030 29.851  1.00 18.00 ? 139 ASN L CB  1 
ATOM   3361 C CG  . ASN C 3 139 ? -9.145  15.328 30.467  1.00 19.35 ? 139 ASN L CG  1 
ATOM   3362 O OD1 . ASN C 3 139 ? -8.853  16.285 29.764  1.00 18.52 ? 139 ASN L OD1 1 
ATOM   3363 N ND2 . ASN C 3 139 ? -9.073  15.369 31.791  1.00 23.51 ? 139 ASN L ND2 1 
ATOM   3364 N N   . PHE C 3 140 ? -10.055 12.623 26.426  1.00 10.86 ? 140 PHE L N   1 
ATOM   3365 C CA  . PHE C 3 140 ? -10.319 11.342 25.783  1.00 12.65 ? 140 PHE L CA  1 
ATOM   3366 C C   . PHE C 3 140 ? -9.108  10.873 24.985  1.00 14.98 ? 140 PHE L C   1 
ATOM   3367 O O   . PHE C 3 140 ? -8.186  11.636 24.688  1.00 12.23 ? 140 PHE L O   1 
ATOM   3368 C CB  . PHE C 3 140 ? -11.539 11.408 24.871  1.00 13.70 ? 140 PHE L CB  1 
ATOM   3369 C CG  . PHE C 3 140 ? -11.426 12.429 23.781  1.00 12.65 ? 140 PHE L CG  1 
ATOM   3370 C CD1 . PHE C 3 140 ? -10.905 12.081 22.547  1.00 15.00 ? 140 PHE L CD1 1 
ATOM   3371 C CD2 . PHE C 3 140 ? -11.858 13.740 23.985  1.00 14.12 ? 140 PHE L CD2 1 
ATOM   3372 C CE1 . PHE C 3 140 ? -10.800 13.014 21.538  1.00 12.87 ? 140 PHE L CE1 1 
ATOM   3373 C CE2 . PHE C 3 140 ? -11.771 14.682 22.969  1.00 15.34 ? 140 PHE L CE2 1 
ATOM   3374 C CZ  . PHE C 3 140 ? -11.239 14.323 21.752  1.00 13.65 ? 140 PHE L CZ  1 
ATOM   3375 N N   . TYR C 3 141 ? -9.121  9.583  24.648  1.00 13.39 ? 141 TYR L N   1 
ATOM   3376 C CA  . TYR C 3 141 ? -8.078  8.995  23.821  1.00 13.96 ? 141 TYR L CA  1 
ATOM   3377 C C   . TYR C 3 141 ? -8.658  7.716  23.244  1.00 14.85 ? 141 TYR L C   1 
ATOM   3378 O O   . TYR C 3 141 ? -9.284  6.953  23.992  1.00 14.78 ? 141 TYR L O   1 
ATOM   3379 C CB  . TYR C 3 141 ? -6.788  8.696  24.607  1.00 13.38 ? 141 TYR L CB  1 
ATOM   3380 C CG  . TYR C 3 141 ? -5.719  8.169  23.684  1.00 12.10 ? 141 TYR L CG  1 
ATOM   3381 C CD1 . TYR C 3 141 ? -5.663  6.819  23.370  1.00 13.46 ? 141 TYR L CD1 1 
ATOM   3382 C CD2 . TYR C 3 141 ? -4.816  9.023  23.077  1.00 11.08 ? 141 TYR L CD2 1 
ATOM   3383 C CE1 . TYR C 3 141 ? -4.721  6.334  22.496  1.00 14.21 ? 141 TYR L CE1 1 
ATOM   3384 C CE2 . TYR C 3 141 ? -3.855  8.546  22.199  1.00 13.40 ? 141 TYR L CE2 1 
ATOM   3385 C CZ  . TYR C 3 141 ? -3.822  7.197  21.907  1.00 16.81 ? 141 TYR L CZ  1 
ATOM   3386 O OH  . TYR C 3 141 ? -2.880  6.688  21.032  1.00 18.64 ? 141 TYR L OH  1 
ATOM   3387 N N   . PRO C 3 142 ? -8.461  7.429  21.948  1.00 13.60 ? 142 PRO L N   1 
ATOM   3388 C CA  . PRO C 3 142 ? -7.661  8.171  20.952  1.00 15.62 ? 142 PRO L CA  1 
ATOM   3389 C C   . PRO C 3 142 ? -8.353  9.404  20.402  1.00 15.98 ? 142 PRO L C   1 
ATOM   3390 O O   . PRO C 3 142 ? -9.472  9.735  20.796  1.00 15.26 ? 142 PRO L O   1 
ATOM   3391 C CB  . PRO C 3 142 ? -7.431  7.126  19.853  1.00 17.32 ? 142 PRO L CB  1 
ATOM   3392 C CG  . PRO C 3 142 ? -8.620  6.229  19.949  1.00 16.74 ? 142 PRO L CG  1 
ATOM   3393 C CD  . PRO C 3 142 ? -8.916  6.129  21.422  1.00 16.17 ? 142 PRO L CD  1 
ATOM   3394 N N   . ARG C 3 143 ? -7.691  10.085 19.460  1.00 17.47 ? 143 ARG L N   1 
ATOM   3395 C CA  . ARG C 3 143 ? -8.135  11.413 19.052  1.00 17.42 ? 143 ARG L CA  1 
ATOM   3396 C C   . ARG C 3 143 ? -9.419  11.382 18.224  1.00 19.98 ? 143 ARG L C   1 
ATOM   3397 O O   . ARG C 3 143 ? -10.193 12.341 18.274  1.00 18.82 ? 143 ARG L O   1 
ATOM   3398 C CB  . ARG C 3 143 ? -7.032  12.127 18.274  1.00 19.93 ? 143 ARG L CB  1 
ATOM   3399 C CG  . ARG C 3 143 ? -7.398  13.573 17.968  1.00 20.60 ? 143 ARG L CG  1 
ATOM   3400 C CD  . ARG C 3 143 ? -6.462  14.204 16.993  1.00 27.53 ? 143 ARG L CD  1 
ATOM   3401 N NE  . ARG C 3 143 ? -7.103  15.357 16.371  1.00 32.53 ? 143 ARG L NE  1 
ATOM   3402 C CZ  . ARG C 3 143 ? -6.462  16.474 16.066  1.00 34.69 ? 143 ARG L CZ  1 
ATOM   3403 N NH1 . ARG C 3 143 ? -5.178  16.627 16.348  1.00 31.29 ? 143 ARG L NH1 1 
ATOM   3404 N NH2 . ARG C 3 143 ? -7.126  17.466 15.472  1.00 32.69 ? 143 ARG L NH2 1 
ATOM   3405 N N   . GLU C 3 144 ? -9.668  10.313 17.463  1.00 19.32 ? 144 GLU L N   1 
ATOM   3406 C CA  . GLU C 3 144 ? -10.839 10.289 16.591  1.00 20.32 ? 144 GLU L CA  1 
ATOM   3407 C C   . GLU C 3 144 ? -12.112 10.361 17.417  1.00 18.23 ? 144 GLU L C   1 
ATOM   3408 O O   . GLU C 3 144 ? -12.298 9.588  18.361  1.00 20.13 ? 144 GLU L O   1 
ATOM   3409 C CB  . GLU C 3 144 ? -10.857 9.028  15.724  1.00 23.25 ? 144 GLU L CB  1 
ATOM   3410 C CG  . GLU C 3 144 ? -9.515  8.637  15.163  1.00 26.02 ? 144 GLU L CG  1 
ATOM   3411 C CD  . GLU C 3 144 ? -8.792  7.683  16.092  1.00 26.39 ? 144 GLU L CD  1 
ATOM   3412 O OE1 . GLU C 3 144 ? -9.450  6.751  16.610  1.00 36.55 ? 144 GLU L OE1 1 
ATOM   3413 O OE2 . GLU C 3 144 ? -7.591  7.884  16.320  1.00 31.15 ? 144 GLU L OE2 1 
ATOM   3414 N N   . ALA C 3 145 ? -12.984 11.303 17.066  1.00 17.64 ? 145 ALA L N   1 
ATOM   3415 C CA  . ALA C 3 145 ? -14.282 11.405 17.701  1.00 18.47 ? 145 ALA L CA  1 
ATOM   3416 C C   . ALA C 3 145 ? -15.253 12.025 16.712  1.00 24.02 ? 145 ALA L C   1 
ATOM   3417 O O   . ALA C 3 145 ? -14.858 12.775 15.815  1.00 25.52 ? 145 ALA L O   1 
ATOM   3418 C CB  . ALA C 3 145 ? -14.215 12.222 18.996  1.00 17.69 ? 145 ALA L CB  1 
ATOM   3419 N N   . LYS C 3 146 ? -16.523 11.677 16.864  1.00 25.52 ? 146 LYS L N   1 
ATOM   3420 C CA  . LYS C 3 146 ? -17.596 12.205 16.032  1.00 23.57 ? 146 LYS L CA  1 
ATOM   3421 C C   . LYS C 3 146 ? -18.538 12.994 16.925  1.00 22.17 ? 146 LYS L C   1 
ATOM   3422 O O   . LYS C 3 146 ? -19.031 12.469 17.931  1.00 25.61 ? 146 LYS L O   1 
ATOM   3423 C CB  . LYS C 3 146 ? -18.333 11.078 15.306  1.00 24.07 ? 146 LYS L CB  1 
ATOM   3424 C CG  . LYS C 3 146 ? -17.531 10.500 14.142  1.00 32.70 ? 146 LYS L CG  1 
ATOM   3425 C CD  . LYS C 3 146 ? -17.578 8.952  14.040  1.00 37.79 ? 146 LYS L CD  1 
ATOM   3426 C CE  . LYS C 3 146 ? -16.548 8.265  14.961  1.00 34.83 ? 146 LYS L CE  1 
ATOM   3427 N NZ  . LYS C 3 146 ? -15.156 8.795  14.809  1.00 29.49 ? 146 LYS L NZ  1 
ATOM   3428 N N   . VAL C 3 147 ? -18.758 14.258 16.581  1.00 22.46 ? 147 VAL L N   1 
ATOM   3429 C CA  . VAL C 3 147 ? -19.690 15.123 17.296  1.00 23.41 ? 147 VAL L CA  1 
ATOM   3430 C C   . VAL C 3 147 ? -20.792 15.511 16.324  1.00 21.39 ? 147 VAL L C   1 
ATOM   3431 O O   . VAL C 3 147 ? -20.517 16.073 15.258  1.00 21.25 ? 147 VAL L O   1 
ATOM   3432 C CB  . VAL C 3 147 ? -19.003 16.371 17.877  1.00 23.83 ? 147 VAL L CB  1 
ATOM   3433 C CG1 . VAL C 3 147 ? -20.012 17.223 18.626  1.00 23.93 ? 147 VAL L CG1 1 
ATOM   3434 C CG2 . VAL C 3 147 ? -17.857 15.960 18.803  1.00 26.46 ? 147 VAL L CG2 1 
ATOM   3435 N N   . GLN C 3 148 ? -22.034 15.207 16.686  1.00 23.04 ? 148 GLN L N   1 
ATOM   3436 C CA  . GLN C 3 148 ? -23.195 15.540 15.873  1.00 25.58 ? 148 GLN L CA  1 
ATOM   3437 C C   . GLN C 3 148 ? -24.129 16.410 16.696  1.00 23.57 ? 148 GLN L C   1 
ATOM   3438 O O   . GLN C 3 148 ? -24.450 16.073 17.841  1.00 26.57 ? 148 GLN L O   1 
ATOM   3439 C CB  . GLN C 3 148 ? -23.918 14.279 15.392  1.00 22.52 ? 148 GLN L CB  1 
ATOM   3440 N N   . TRP C 3 149 ? -24.550 17.533 16.120  1.00 21.38 ? 149 TRP L N   1 
ATOM   3441 C CA  . TRP C 3 149 ? -25.511 18.410 16.774  1.00 23.72 ? 149 TRP L CA  1 
ATOM   3442 C C   . TRP C 3 149 ? -26.924 18.067 16.331  1.00 26.72 ? 149 TRP L C   1 
ATOM   3443 O O   . TRP C 3 149 ? -27.157 17.754 15.162  1.00 27.36 ? 149 TRP L O   1 
ATOM   3444 C CB  . TRP C 3 149 ? -25.213 19.867 16.445  1.00 24.39 ? 149 TRP L CB  1 
ATOM   3445 C CG  . TRP C 3 149 ? -24.054 20.414 17.196  1.00 22.59 ? 149 TRP L CG  1 
ATOM   3446 C CD1 . TRP C 3 149 ? -22.774 20.562 16.736  1.00 20.38 ? 149 TRP L CD1 1 
ATOM   3447 C CD2 . TRP C 3 149 ? -24.056 20.891 18.551  1.00 20.26 ? 149 TRP L CD2 1 
ATOM   3448 N NE1 . TRP C 3 149 ? -21.982 21.113 17.724  1.00 20.51 ? 149 TRP L NE1 1 
ATOM   3449 C CE2 . TRP C 3 149 ? -22.747 21.324 18.843  1.00 19.14 ? 149 TRP L CE2 1 
ATOM   3450 C CE3 . TRP C 3 149 ? -25.040 21.003 19.538  1.00 20.91 ? 149 TRP L CE3 1 
ATOM   3451 C CZ2 . TRP C 3 149 ? -22.397 21.856 20.082  1.00 18.52 ? 149 TRP L CZ2 1 
ATOM   3452 C CZ3 . TRP C 3 149 ? -24.698 21.526 20.766  1.00 18.90 ? 149 TRP L CZ3 1 
ATOM   3453 C CH2 . TRP C 3 149 ? -23.382 21.948 21.033  1.00 19.85 ? 149 TRP L CH2 1 
ATOM   3454 N N   . LYS C 3 150 ? -27.863 18.120 17.271  1.00 25.15 ? 150 LYS L N   1 
ATOM   3455 C CA  . LYS C 3 150 ? -29.276 17.989 16.943  1.00 29.81 ? 150 LYS L CA  1 
ATOM   3456 C C   . LYS C 3 150 ? -30.064 19.069 17.662  1.00 30.12 ? 150 LYS L C   1 
ATOM   3457 O O   . LYS C 3 150 ? -29.750 19.431 18.801  1.00 29.36 ? 150 LYS L O   1 
ATOM   3458 C CB  . LYS C 3 150 ? -29.829 16.614 17.316  1.00 29.94 ? 150 LYS L CB  1 
ATOM   3459 C CG  . LYS C 3 150 ? -28.933 15.468 16.928  1.00 31.17 ? 150 LYS L CG  1 
ATOM   3460 C CD  . LYS C 3 150 ? -29.692 14.412 16.157  1.00 39.40 ? 150 LYS L CD  1 
ATOM   3461 C CE  . LYS C 3 150 ? -29.023 13.061 16.311  1.00 39.57 ? 150 LYS L CE  1 
ATOM   3462 N NZ  . LYS C 3 150 ? -28.960 12.680 17.751  1.00 42.10 ? 150 LYS L NZ  1 
ATOM   3463 N N   . VAL C 3 151 ? -31.084 19.586 16.984  1.00 31.44 ? 151 VAL L N   1 
ATOM   3464 C CA  . VAL C 3 151 ? -31.931 20.642 17.516  1.00 30.36 ? 151 VAL L CA  1 
ATOM   3465 C C   . VAL C 3 151 ? -33.374 20.237 17.259  1.00 31.10 ? 151 VAL L C   1 
ATOM   3466 O O   . VAL C 3 151 ? -33.790 20.141 16.101  1.00 31.56 ? 151 VAL L O   1 
ATOM   3467 C CB  . VAL C 3 151 ? -31.620 22.001 16.872  1.00 30.71 ? 151 VAL L CB  1 
ATOM   3468 C CG1 . VAL C 3 151 ? -32.530 23.056 17.428  1.00 29.19 ? 151 VAL L CG1 1 
ATOM   3469 C CG2 . VAL C 3 151 ? -30.161 22.386 17.107  1.00 25.79 ? 151 VAL L CG2 1 
ATOM   3470 N N   . ASP C 3 152 ? -34.136 20.009 18.332  1.00 33.64 ? 152 ASP L N   1 
ATOM   3471 C CA  . ASP C 3 152 ? -35.440 19.342 18.234  1.00 34.37 ? 152 ASP L CA  1 
ATOM   3472 C C   . ASP C 3 152 ? -35.335 18.096 17.358  1.00 33.73 ? 152 ASP L C   1 
ATOM   3473 O O   . ASP C 3 152 ? -36.166 17.845 16.485  1.00 35.40 ? 152 ASP L O   1 
ATOM   3474 C CB  . ASP C 3 152 ? -36.522 20.295 17.721  1.00 29.50 ? 152 ASP L CB  1 
ATOM   3475 C CG  . ASP C 3 152 ? -36.940 21.312 18.762  1.00 30.36 ? 152 ASP L CG  1 
ATOM   3476 O OD1 . ASP C 3 152 ? -36.661 21.087 19.956  1.00 29.69 ? 152 ASP L OD1 1 
ATOM   3477 O OD2 . ASP C 3 152 ? -37.554 22.331 18.392  1.00 36.57 ? 152 ASP L OD2 1 
ATOM   3478 N N   . ASN C 3 153 ? -34.266 17.329 17.588  1.00 36.51 ? 153 ASN L N   1 
ATOM   3479 C CA  . ASN C 3 153 ? -33.922 16.108 16.863  1.00 34.59 ? 153 ASN L CA  1 
ATOM   3480 C C   . ASN C 3 153 ? -33.579 16.384 15.401  1.00 35.64 ? 153 ASN L C   1 
ATOM   3481 O O   . ASN C 3 153 ? -33.333 15.444 14.638  1.00 34.98 ? 153 ASN L O   1 
ATOM   3482 C CB  . ASN C 3 153 ? -35.046 15.073 16.981  1.00 37.30 ? 153 ASN L CB  1 
ATOM   3483 C CG  . ASN C 3 153 ? -35.200 14.551 18.390  1.00 39.65 ? 153 ASN L CG  1 
ATOM   3484 O OD1 . ASN C 3 153 ? -35.918 15.135 19.208  1.00 48.25 ? 153 ASN L OD1 1 
ATOM   3485 N ND2 . ASN C 3 153 ? -34.517 13.446 18.691  1.00 42.73 ? 153 ASN L ND2 1 
ATOM   3486 N N   . ALA C 3 154 ? -33.534 17.657 15.003  1.00 32.40 ? 154 ALA L N   1 
ATOM   3487 C CA  . ALA C 3 154 ? -33.110 18.019 13.654  1.00 33.98 ? 154 ALA L CA  1 
ATOM   3488 C C   . ALA C 3 154 ? -31.585 18.029 13.604  1.00 36.48 ? 154 ALA L C   1 
ATOM   3489 O O   . ALA C 3 154 ? -30.933 18.889 14.209  1.00 33.51 ? 154 ALA L O   1 
ATOM   3490 C CB  . ALA C 3 154 ? -33.689 19.369 13.243  1.00 34.92 ? 154 ALA L CB  1 
ATOM   3491 N N   . LEU C 3 155 ? -31.025 17.077 12.868  1.00 35.74 ? 155 LEU L N   1 
ATOM   3492 C CA  . LEU C 3 155 ? -29.581 16.918 12.783  1.00 35.80 ? 155 LEU L CA  1 
ATOM   3493 C C   . LEU C 3 155 ? -28.953 18.070 12.004  1.00 38.62 ? 155 LEU L C   1 
ATOM   3494 O O   . LEU C 3 155 ? -29.319 18.328 10.852  1.00 38.80 ? 155 LEU L O   1 
ATOM   3495 C CB  . LEU C 3 155 ? -29.271 15.579 12.123  1.00 37.69 ? 155 LEU L CB  1 
ATOM   3496 C CG  . LEU C 3 155 ? -27.864 15.221 11.677  1.00 39.24 ? 155 LEU L CG  1 
ATOM   3497 C CD1 . LEU C 3 155 ? -27.686 13.730 11.842  1.00 43.76 ? 155 LEU L CD1 1 
ATOM   3498 C CD2 . LEU C 3 155 ? -27.649 15.614 10.220  1.00 42.68 ? 155 LEU L CD2 1 
ATOM   3499 N N   . GLN C 3 156 ? -27.984 18.748 12.621  1.00 33.16 ? 156 GLN L N   1 
ATOM   3500 C CA  . GLN C 3 156 ? -27.446 19.989 12.080  1.00 30.13 ? 156 GLN L CA  1 
ATOM   3501 C C   . GLN C 3 156 ? -26.261 19.729 11.160  1.00 30.87 ? 156 GLN L C   1 
ATOM   3502 O O   . GLN C 3 156 ? -25.520 18.757 11.326  1.00 32.31 ? 156 GLN L O   1 
ATOM   3503 C CB  . GLN C 3 156 ? -27.021 20.921 13.213  1.00 28.37 ? 156 GLN L CB  1 
ATOM   3504 C CG  . GLN C 3 156 ? -28.127 21.194 14.207  1.00 29.07 ? 156 GLN L CG  1 
ATOM   3505 C CD  . GLN C 3 156 ? -29.248 21.996 13.597  1.00 29.18 ? 156 GLN L CD  1 
ATOM   3506 O OE1 . GLN C 3 156 ? -29.032 23.102 13.106  1.00 30.30 ? 156 GLN L OE1 1 
ATOM   3507 N NE2 . GLN C 3 156 ? -30.456 21.439 13.610  1.00 33.41 ? 156 GLN L NE2 1 
ATOM   3508 N N   . SER C 3 157 ? -26.071 20.627 10.193  1.00 30.71 ? 157 SER L N   1 
ATOM   3509 C CA  . SER C 3 157 ? -24.953 20.510 9.265   1.00 29.25 ? 157 SER L CA  1 
ATOM   3510 C C   . SER C 3 157 ? -24.494 21.886 8.813   1.00 28.32 ? 157 SER L C   1 
ATOM   3511 O O   . SER C 3 157 ? -25.314 22.727 8.437   1.00 30.80 ? 157 SER L O   1 
ATOM   3512 C CB  . SER C 3 157 ? -25.334 19.666 8.047   1.00 33.18 ? 157 SER L CB  1 
ATOM   3513 O OG  . SER C 3 157 ? -25.507 18.310 8.424   1.00 41.47 ? 157 SER L OG  1 
ATOM   3514 N N   . GLY C 3 158 ? -23.185 22.116 8.850   1.00 24.48 ? 158 GLY L N   1 
ATOM   3515 C CA  . GLY C 3 158 ? -22.609 23.302 8.262   1.00 27.85 ? 158 GLY L CA  1 
ATOM   3516 C C   . GLY C 3 158 ? -22.511 24.509 9.169   1.00 24.57 ? 158 GLY L C   1 
ATOM   3517 O O   . GLY C 3 158 ? -21.874 25.499 8.776   1.00 26.61 ? 158 GLY L O   1 
ATOM   3518 N N   . ASN C 3 159 ? -23.103 24.466 10.370  1.00 24.20 ? 159 ASN L N   1 
ATOM   3519 C CA  . ASN C 3 159 ? -23.115 25.604 11.289  1.00 21.71 ? 159 ASN L CA  1 
ATOM   3520 C C   . ASN C 3 159 ? -22.362 25.308 12.585  1.00 20.77 ? 159 ASN L C   1 
ATOM   3521 O O   . ASN C 3 159 ? -22.725 25.823 13.644  1.00 19.49 ? 159 ASN L O   1 
ATOM   3522 C CB  . ASN C 3 159 ? -24.552 26.024 11.605  1.00 22.88 ? 159 ASN L CB  1 
ATOM   3523 C CG  . ASN C 3 159 ? -25.413 24.857 12.035  1.00 23.97 ? 159 ASN L CG  1 
ATOM   3524 O OD1 . ASN C 3 159 ? -24.940 23.725 12.121  1.00 26.44 ? 159 ASN L OD1 1 
ATOM   3525 N ND2 . ASN C 3 159 ? -26.691 25.124 12.309  1.00 26.14 ? 159 ASN L ND2 1 
ATOM   3526 N N   . SER C 3 160 ? -21.320 24.484 12.525  1.00 20.50 ? 160 SER L N   1 
ATOM   3527 C CA  . SER C 3 160 ? -20.507 24.212 13.702  1.00 17.39 ? 160 SER L CA  1 
ATOM   3528 C C   . SER C 3 160 ? -19.031 24.218 13.325  1.00 21.18 ? 160 SER L C   1 
ATOM   3529 O O   . SER C 3 160 ? -18.664 23.982 12.171  1.00 18.95 ? 160 SER L O   1 
ATOM   3530 C CB  . SER C 3 160 ? -20.887 22.878 14.363  1.00 18.52 ? 160 SER L CB  1 
ATOM   3531 O OG  . SER C 3 160 ? -20.739 21.799 13.455  1.00 21.98 ? 160 SER L OG  1 
ATOM   3532 N N   . GLN C 3 161 ? -18.188 24.502 14.317  1.00 17.89 ? 161 GLN L N   1 
ATOM   3533 C CA  . GLN C 3 161 ? -16.739 24.435 14.165  1.00 18.06 ? 161 GLN L CA  1 
ATOM   3534 C C   . GLN C 3 161 ? -16.147 23.746 15.386  1.00 18.24 ? 161 GLN L C   1 
ATOM   3535 O O   . GLN C 3 161 ? -16.661 23.883 16.502  1.00 17.09 ? 161 GLN L O   1 
ATOM   3536 C CB  . GLN C 3 161 ? -16.101 25.825 14.005  1.00 19.52 ? 161 GLN L CB  1 
ATOM   3537 C CG  . GLN C 3 161 ? -16.247 26.475 12.640  1.00 22.41 ? 161 GLN L CG  1 
ATOM   3538 C CD  . GLN C 3 161 ? -15.567 27.844 12.592  1.00 24.52 ? 161 GLN L CD  1 
ATOM   3539 O OE1 . GLN C 3 161 ? -15.978 28.783 13.277  1.00 20.07 ? 161 GLN L OE1 1 
ATOM   3540 N NE2 . GLN C 3 161 ? -14.526 27.961 11.778  1.00 23.30 ? 161 GLN L NE2 1 
ATOM   3541 N N   . GLU C 3 162 ? -15.067 22.999 15.159  1.00 18.60 ? 162 GLU L N   1 
ATOM   3542 C CA  . GLU C 3 162 ? -14.391 22.237 16.197  1.00 19.34 ? 162 GLU L CA  1 
ATOM   3543 C C   . GLU C 3 162 ? -12.986 22.773 16.421  1.00 16.32 ? 162 GLU L C   1 
ATOM   3544 O O   . GLU C 3 162 ? -12.345 23.301 15.510  1.00 18.02 ? 162 GLU L O   1 
ATOM   3545 C CB  . GLU C 3 162 ? -14.287 20.752 15.836  1.00 19.78 ? 162 GLU L CB  1 
ATOM   3546 C CG  . GLU C 3 162 ? -15.590 20.018 15.791  1.00 25.46 ? 162 GLU L CG  1 
ATOM   3547 C CD  . GLU C 3 162 ? -15.389 18.541 15.591  1.00 20.80 ? 162 GLU L CD  1 
ATOM   3548 O OE1 . GLU C 3 162 ? -14.224 18.124 15.372  1.00 26.73 ? 162 GLU L OE1 1 
ATOM   3549 O OE2 . GLU C 3 162 ? -16.386 17.791 15.668  1.00 28.84 ? 162 GLU L OE2 1 
ATOM   3550 N N   . SER C 3 163 ? -12.504 22.608 17.642  1.00 16.26 ? 163 SER L N   1 
ATOM   3551 C CA  . SER C 3 163 ? -11.134 22.907 18.001  1.00 15.26 ? 163 SER L CA  1 
ATOM   3552 C C   . SER C 3 163 ? -10.654 21.789 18.914  1.00 15.48 ? 163 SER L C   1 
ATOM   3553 O O   . SER C 3 163 ? -11.434 21.273 19.715  1.00 13.16 ? 163 SER L O   1 
ATOM   3554 C CB  . SER C 3 163 ? -11.063 24.276 18.688  1.00 16.20 ? 163 SER L CB  1 
ATOM   3555 O OG  . SER C 3 163 ? -9.739  24.653 18.955  1.00 18.78 ? 163 SER L OG  1 
ATOM   3556 N N   . VAL C 3 164 ? -9.390  21.386 18.779  1.00 13.42 ? 164 VAL L N   1 
ATOM   3557 C CA  . VAL C 3 164 ? -8.852  20.260 19.541  1.00 14.67 ? 164 VAL L CA  1 
ATOM   3558 C C   . VAL C 3 164 ? -7.530  20.668 20.178  1.00 16.32 ? 164 VAL L C   1 
ATOM   3559 O O   . VAL C 3 164 ? -6.706  21.330 19.539  1.00 16.01 ? 164 VAL L O   1 
ATOM   3560 C CB  . VAL C 3 164 ? -8.650  19.008 18.657  1.00 15.92 ? 164 VAL L CB  1 
ATOM   3561 C CG1 . VAL C 3 164 ? -8.229  17.822 19.513  1.00 16.34 ? 164 VAL L CG1 1 
ATOM   3562 C CG2 . VAL C 3 164 ? -9.900  18.678 17.880  1.00 17.08 ? 164 VAL L CG2 1 
ATOM   3563 N N   . THR C 3 165 ? -7.313  20.264 21.431  1.00 13.75 ? 165 THR L N   1 
ATOM   3564 C CA  . THR C 3 165 ? -6.039  20.558 22.064  1.00 13.25 ? 165 THR L CA  1 
ATOM   3565 C C   . THR C 3 165 ? -4.951  19.639 21.509  1.00 16.27 ? 165 THR L C   1 
ATOM   3566 O O   . THR C 3 165 ? -5.222  18.628 20.855  1.00 16.93 ? 165 THR L O   1 
ATOM   3567 C CB  . THR C 3 165 ? -6.136  20.392 23.585  1.00 17.64 ? 165 THR L CB  1 
ATOM   3568 O OG1 . THR C 3 165 ? -6.610  19.070 23.887  1.00 15.38 ? 165 THR L OG1 1 
ATOM   3569 C CG2 . THR C 3 165 ? -7.093  21.427 24.189  1.00 15.99 ? 165 THR L CG2 1 
ATOM   3570 N N   . GLU C 3 166 ? -3.701  20.002 21.773  1.00 16.64 ? 166 GLU L N   1 
ATOM   3571 C CA  . GLU C 3 166 ? -2.640  19.035 21.551  1.00 17.67 ? 166 GLU L CA  1 
ATOM   3572 C C   . GLU C 3 166 ? -2.610  18.036 22.700  1.00 16.66 ? 166 GLU L C   1 
ATOM   3573 O O   . GLU C 3 166 ? -3.183  18.266 23.774  1.00 16.28 ? 166 GLU L O   1 
ATOM   3574 C CB  . GLU C 3 166 ? -1.291  19.729 21.399  1.00 19.31 ? 166 GLU L CB  1 
ATOM   3575 C CG  . GLU C 3 166 ? -1.192  20.543 20.110  1.00 23.09 ? 166 GLU L CG  1 
ATOM   3576 C CD  . GLU C 3 166 ? -1.368  19.672 18.861  1.00 27.03 ? 166 GLU L CD  1 
ATOM   3577 O OE1 . GLU C 3 166 ? -0.494  18.820 18.581  1.00 31.03 ? 166 GLU L OE1 1 
ATOM   3578 O OE2 . GLU C 3 166 ? -2.390  19.824 18.163  1.00 27.05 ? 166 GLU L OE2 1 
ATOM   3579 N N   . GLN C 3 167 ? -1.947  16.906 22.458  1.00 15.89 ? 167 GLN L N   1 
ATOM   3580 C CA  . GLN C 3 167 ? -1.947  15.824 23.439  1.00 14.75 ? 167 GLN L CA  1 
ATOM   3581 C C   . GLN C 3 167 ? -1.437  16.322 24.782  1.00 14.56 ? 167 GLN L C   1 
ATOM   3582 O O   . GLN C 3 167 ? -0.394  16.975 24.855  1.00 13.35 ? 167 GLN L O   1 
ATOM   3583 C CB  . GLN C 3 167 ? -1.081  14.665 22.945  1.00 17.52 ? 167 GLN L CB  1 
ATOM   3584 C CG  . GLN C 3 167 ? -1.450  13.348 23.555  1.00 15.52 ? 167 GLN L CG  1 
ATOM   3585 C CD  . GLN C 3 167 ? -0.814  12.143 22.863  1.00 17.09 ? 167 GLN L CD  1 
ATOM   3586 O OE1 . GLN C 3 167 ? 0.131   12.274 22.082  1.00 16.43 ? 167 GLN L OE1 1 
ATOM   3587 N NE2 . GLN C 3 167 ? -1.326  10.960 23.170  1.00 15.61 ? 167 GLN L NE2 1 
ATOM   3588 N N   . ASP C 3 168 ? -2.191  16.034 25.844  1.00 14.18 ? 168 ASP L N   1 
ATOM   3589 C CA  . ASP C 3 168 ? -1.836  16.532 27.169  1.00 14.36 ? 168 ASP L CA  1 
ATOM   3590 C C   . ASP C 3 168 ? -0.500  15.956 27.625  1.00 16.23 ? 168 ASP L C   1 
ATOM   3591 O O   . ASP C 3 168 ? -0.243  14.761 27.478  1.00 15.99 ? 168 ASP L O   1 
ATOM   3592 C CB  . ASP C 3 168 ? -2.935  16.193 28.167  1.00 13.99 ? 168 ASP L CB  1 
ATOM   3593 C CG  . ASP C 3 168 ? -2.714  16.868 29.508  1.00 17.61 ? 168 ASP L CG  1 
ATOM   3594 O OD1 . ASP C 3 168 ? -2.181  16.224 30.426  1.00 18.26 ? 168 ASP L OD1 1 
ATOM   3595 O OD2 . ASP C 3 168 ? -3.025  18.069 29.621  1.00 23.39 ? 168 ASP L OD2 1 
ATOM   3596 N N   . SER C 3 169 ? 0.366   16.817 28.163  1.00 21.42 ? 169 SER L N   1 
ATOM   3597 C CA  . SER C 3 169 ? 1.704   16.363 28.531  1.00 19.26 ? 169 SER L CA  1 
ATOM   3598 C C   . SER C 3 169 ? 1.719   15.554 29.823  1.00 19.52 ? 169 SER L C   1 
ATOM   3599 O O   . SER C 3 169 ? 2.713   14.872 30.095  1.00 23.68 ? 169 SER L O   1 
ATOM   3600 C CB  . SER C 3 169 ? 2.663   17.558 28.635  1.00 22.24 ? 169 SER L CB  1 
ATOM   3601 O OG  . SER C 3 169 ? 2.168   18.547 29.514  1.00 28.08 ? 169 SER L OG  1 
ATOM   3602 N N   . LYS C 3 170 ? 0.648   15.592 30.610  1.00 16.71 ? 170 LYS L N   1 
ATOM   3603 C CA  . LYS C 3 170 ? 0.559   14.769 31.808  1.00 19.23 ? 170 LYS L CA  1 
ATOM   3604 C C   . LYS C 3 170 ? -0.139  13.437 31.551  1.00 19.10 ? 170 LYS L C   1 
ATOM   3605 O O   . LYS C 3 170 ? 0.400   12.379 31.901  1.00 20.73 ? 170 LYS L O   1 
ATOM   3606 C CB  . LYS C 3 170 ? -0.165  15.533 32.929  1.00 20.51 ? 170 LYS L CB  1 
ATOM   3607 N N   . ASP C 3 171 ? -1.321  13.451 30.936  1.00 16.31 ? 171 ASP L N   1 
ATOM   3608 C CA  . ASP C 3 171 ? -2.106  12.230 30.816  1.00 17.12 ? 171 ASP L CA  1 
ATOM   3609 C C   . ASP C 3 171 ? -2.307  11.763 29.378  1.00 13.10 ? 171 ASP L C   1 
ATOM   3610 O O   . ASP C 3 171 ? -3.014  10.774 29.162  1.00 14.50 ? 171 ASP L O   1 
ATOM   3611 C CB  . ASP C 3 171 ? -3.466  12.397 31.532  1.00 16.52 ? 171 ASP L CB  1 
ATOM   3612 C CG  . ASP C 3 171 ? -4.362  13.465 30.902  1.00 18.24 ? 171 ASP L CG  1 
ATOM   3613 O OD1 . ASP C 3 171 ? -4.269  13.707 29.688  1.00 14.10 ? 171 ASP L OD1 1 
ATOM   3614 O OD2 . ASP C 3 171 ? -5.174  14.091 31.623  1.00 20.18 ? 171 ASP L OD2 1 
ATOM   3615 N N   . SER C 3 172 ? -1.718  12.448 28.398  1.00 13.54 ? 172 SER L N   1 
ATOM   3616 C CA  . SER C 3 172 ? -1.700  12.008 26.998  1.00 13.39 ? 172 SER L CA  1 
ATOM   3617 C C   . SER C 3 172 ? -3.092  11.955 26.365  1.00 13.21 ? 172 SER L C   1 
ATOM   3618 O O   . SER C 3 172 ? -3.288  11.280 25.343  1.00 13.51 ? 172 SER L O   1 
ATOM   3619 C CB  . SER C 3 172 ? -1.001  10.646 26.848  1.00 16.17 ? 172 SER L CB  1 
ATOM   3620 O OG  . SER C 3 172 ? 0.338   10.694 27.325  1.00 15.68 ? 172 SER L OG  1 
ATOM   3621 N N   . THR C 3 173 ? -4.076  12.655 26.929  1.00 10.51 ? 173 THR L N   1 
ATOM   3622 C CA  . THR C 3 173 ? -5.405  12.706 26.331  1.00 10.15 ? 173 THR L CA  1 
ATOM   3623 C C   . THR C 3 173 ? -5.570  13.948 25.452  1.00 11.27 ? 173 THR L C   1 
ATOM   3624 O O   . THR C 3 173 ? -4.716  14.842 25.406  1.00 11.39 ? 173 THR L O   1 
ATOM   3625 C CB  . THR C 3 173 ? -6.498  12.709 27.406  1.00 11.89 ? 173 THR L CB  1 
ATOM   3626 O OG1 . THR C 3 173 ? -6.399  13.905 28.204  1.00 13.72 ? 173 THR L OG1 1 
ATOM   3627 C CG2 . THR C 3 173 ? -6.366  11.508 28.299  1.00 12.37 ? 173 THR L CG2 1 
ATOM   3628 N N   . TYR C 3 174 ? -6.701  13.982 24.751  1.00 12.58 ? 174 TYR L N   1 
ATOM   3629 C CA  . TYR C 3 174 ? -7.141  15.099 23.934  1.00 12.14 ? 174 TYR L CA  1 
ATOM   3630 C C   . TYR C 3 174 ? -8.429  15.660 24.509  1.00 13.26 ? 174 TYR L C   1 
ATOM   3631 O O   . TYR C 3 174 ? -9.190  14.968 25.190  1.00 13.13 ? 174 TYR L O   1 
ATOM   3632 C CB  . TYR C 3 174 ? -7.368  14.672 22.472  1.00 14.63 ? 174 TYR L CB  1 
ATOM   3633 C CG  . TYR C 3 174 ? -6.107  14.229 21.799  1.00 14.12 ? 174 TYR L CG  1 
ATOM   3634 C CD1 . TYR C 3 174 ? -5.227  15.160 21.275  1.00 15.06 ? 174 TYR L CD1 1 
ATOM   3635 C CD2 . TYR C 3 174 ? -5.770  12.877 21.711  1.00 15.55 ? 174 TYR L CD2 1 
ATOM   3636 C CE1 . TYR C 3 174 ? -4.052  14.784 20.675  1.00 17.77 ? 174 TYR L CE1 1 
ATOM   3637 C CE2 . TYR C 3 174 ? -4.579  12.486 21.108  1.00 16.85 ? 174 TYR L CE2 1 
ATOM   3638 C CZ  . TYR C 3 174 ? -3.727  13.438 20.589  1.00 16.01 ? 174 TYR L CZ  1 
ATOM   3639 O OH  . TYR C 3 174 ? -2.537  13.063 19.986  1.00 17.31 ? 174 TYR L OH  1 
ATOM   3640 N N   . SER C 3 175 ? -8.668  16.938 24.247  1.00 10.97 ? 175 SER L N   1 
ATOM   3641 C CA  . SER C 3 175 ? -9.976  17.510 24.489  1.00 12.94 ? 175 SER L CA  1 
ATOM   3642 C C   . SER C 3 175 ? -10.397 18.273 23.246  1.00 13.03 ? 175 SER L C   1 
ATOM   3643 O O   . SER C 3 175 ? -9.566  18.690 22.424  1.00 12.94 ? 175 SER L O   1 
ATOM   3644 C CB  . SER C 3 175 ? -9.993  18.406 25.725  1.00 15.72 ? 175 SER L CB  1 
ATOM   3645 O OG  . SER C 3 175 ? -9.625  17.666 26.888  1.00 14.16 ? 175 SER L OG  1 
ATOM   3646 N N   . LEU C 3 176 ? -11.707 18.404 23.093  1.00 12.69 ? 176 LEU L N   1 
ATOM   3647 C CA  . LEU C 3 176 ? -12.290 18.965 21.884  1.00 12.85 ? 176 LEU L CA  1 
ATOM   3648 C C   . LEU C 3 176 ? -13.508 19.782 22.269  1.00 17.70 ? 176 LEU L C   1 
ATOM   3649 O O   . LEU C 3 176 ? -14.287 19.382 23.146  1.00 13.69 ? 176 LEU L O   1 
ATOM   3650 C CB  . LEU C 3 176 ? -12.677 17.858 20.889  1.00 14.57 ? 176 LEU L CB  1 
ATOM   3651 C CG  . LEU C 3 176 ? -13.379 18.185 19.563  1.00 14.87 ? 176 LEU L CG  1 
ATOM   3652 C CD1 . LEU C 3 176 ? -13.032 17.110 18.567  1.00 18.28 ? 176 LEU L CD1 1 
ATOM   3653 C CD2 . LEU C 3 176 ? -14.901 18.286 19.723  1.00 17.53 ? 176 LEU L CD2 1 
ATOM   3654 N N   . SER C 3 177 ? -13.666 20.923 21.603  1.00 13.48 ? 177 SER L N   1 
ATOM   3655 C CA  . SER C 3 177 ? -14.870 21.727 21.714  1.00 14.63 ? 177 SER L CA  1 
ATOM   3656 C C   . SER C 3 177 ? -15.526 21.788 20.347  1.00 17.26 ? 177 SER L C   1 
ATOM   3657 O O   . SER C 3 177 ? -14.844 21.862 19.322  1.00 18.27 ? 177 SER L O   1 
ATOM   3658 C CB  . SER C 3 177 ? -14.567 23.137 22.227  1.00 19.87 ? 177 SER L CB  1 
ATOM   3659 O OG  . SER C 3 177 ? -13.837 23.866 21.256  1.00 22.12 ? 177 SER L OG  1 
ATOM   3660 N N   . SER C 3 178 ? -16.846 21.693 20.331  1.00 17.07 ? 178 SER L N   1 
ATOM   3661 C CA  . SER C 3 178 ? -17.637 21.927 19.134  1.00 18.62 ? 178 SER L CA  1 
ATOM   3662 C C   . SER C 3 178 ? -18.595 23.058 19.453  1.00 18.38 ? 178 SER L C   1 
ATOM   3663 O O   . SER C 3 178 ? -19.269 23.026 20.490  1.00 19.29 ? 178 SER L O   1 
ATOM   3664 C CB  . SER C 3 178 ? -18.397 20.676 18.705  1.00 20.64 ? 178 SER L CB  1 
ATOM   3665 O OG  . SER C 3 178 ? -19.054 20.896 17.473  1.00 21.08 ? 178 SER L OG  1 
ATOM   3666 N N   . THR C 3 179 ? -18.622 24.076 18.599  1.00 18.39 ? 179 THR L N   1 
ATOM   3667 C CA  . THR C 3 179 ? -19.476 25.237 18.823  1.00 18.34 ? 179 THR L CA  1 
ATOM   3668 C C   . THR C 3 179 ? -20.497 25.327 17.701  1.00 18.74 ? 179 THR L C   1 
ATOM   3669 O O   . THR C 3 179 ? -20.129 25.404 16.525  1.00 15.00 ? 179 THR L O   1 
ATOM   3670 C CB  . THR C 3 179 ? -18.656 26.521 18.913  1.00 17.07 ? 179 THR L CB  1 
ATOM   3671 O OG1 . THR C 3 179 ? -17.897 26.681 17.713  1.00 27.48 ? 179 THR L OG1 1 
ATOM   3672 C CG2 . THR C 3 179 ? -17.710 26.428 20.053  1.00 13.28 ? 179 THR L CG2 1 
ATOM   3673 N N   . LEU C 3 180 ? -21.770 25.306 18.073  1.00 17.58 ? 180 LEU L N   1 
ATOM   3674 C CA  . LEU C 3 180 ? -22.878 25.468 17.149  1.00 17.60 ? 180 LEU L CA  1 
ATOM   3675 C C   . LEU C 3 180 ? -23.326 26.923 17.199  1.00 15.99 ? 180 LEU L C   1 
ATOM   3676 O O   . LEU C 3 180 ? -23.600 27.457 18.283  1.00 18.43 ? 180 LEU L O   1 
ATOM   3677 C CB  . LEU C 3 180 ? -24.015 24.519 17.545  1.00 19.68 ? 180 LEU L CB  1 
ATOM   3678 C CG  . LEU C 3 180 ? -25.365 24.638 16.849  1.00 19.32 ? 180 LEU L CG  1 
ATOM   3679 C CD1 . LEU C 3 180 ? -25.271 24.069 15.454  1.00 22.30 ? 180 LEU L CD1 1 
ATOM   3680 C CD2 . LEU C 3 180 ? -26.430 23.917 17.675  1.00 22.34 ? 180 LEU L CD2 1 
ATOM   3681 N N   . THR C 3 181 ? -23.362 27.583 16.046  1.00 17.65 ? 181 THR L N   1 
ATOM   3682 C CA  . THR C 3 181 ? -23.697 29.003 16.004  1.00 18.55 ? 181 THR L CA  1 
ATOM   3683 C C   . THR C 3 181 ? -25.024 29.174 15.281  1.00 18.87 ? 181 THR L C   1 
ATOM   3684 O O   . THR C 3 181 ? -25.173 28.735 14.135  1.00 17.76 ? 181 THR L O   1 
ATOM   3685 C CB  . THR C 3 181 ? -22.600 29.839 15.334  1.00 21.54 ? 181 THR L CB  1 
ATOM   3686 O OG1 . THR C 3 181 ? -21.357 29.637 16.019  1.00 19.75 ? 181 THR L OG1 1 
ATOM   3687 C CG2 . THR C 3 181 ? -22.940 31.318 15.426  1.00 16.40 ? 181 THR L CG2 1 
ATOM   3688 N N   . LEU C 3 182 ? -25.980 29.806 15.960  1.00 19.97 ? 182 LEU L N   1 
ATOM   3689 C CA  . LEU C 3 182 ? -27.312 30.055 15.431  1.00 18.59 ? 182 LEU L CA  1 
ATOM   3690 C C   . LEU C 3 182 ? -27.678 31.497 15.711  1.00 18.88 ? 182 LEU L C   1 
ATOM   3691 O O   . LEU C 3 182 ? -27.189 32.095 16.671  1.00 19.79 ? 182 LEU L O   1 
ATOM   3692 C CB  . LEU C 3 182 ? -28.368 29.144 16.078  1.00 18.95 ? 182 LEU L CB  1 
ATOM   3693 C CG  . LEU C 3 182 ? -28.265 27.626 15.962  1.00 22.50 ? 182 LEU L CG  1 
ATOM   3694 C CD1 . LEU C 3 182 ? -29.281 26.971 16.888  1.00 27.66 ? 182 LEU L CD1 1 
ATOM   3695 C CD2 . LEU C 3 182 ? -28.471 27.178 14.523  1.00 27.80 ? 182 LEU L CD2 1 
ATOM   3696 N N   . SER C 3 183 ? -28.549 32.054 14.877  1.00 21.76 ? 183 SER L N   1 
ATOM   3697 C CA  . SER C 3 183 ? -29.089 33.363 15.200  1.00 20.36 ? 183 SER L CA  1 
ATOM   3698 C C   . SER C 3 183 ? -29.998 33.252 16.420  1.00 23.24 ? 183 SER L C   1 
ATOM   3699 O O   . SER C 3 183 ? -30.519 32.177 16.744  1.00 23.04 ? 183 SER L O   1 
ATOM   3700 C CB  . SER C 3 183 ? -29.866 33.932 14.021  1.00 21.16 ? 183 SER L CB  1 
ATOM   3701 O OG  . SER C 3 183 ? -31.093 33.241 13.859  1.00 23.15 ? 183 SER L OG  1 
ATOM   3702 N N   . LYS C 3 184 ? -30.164 34.375 17.122  1.00 22.28 ? 184 LYS L N   1 
ATOM   3703 C CA  . LYS C 3 184 ? -31.085 34.389 18.256  1.00 24.42 ? 184 LYS L CA  1 
ATOM   3704 C C   . LYS C 3 184 ? -32.471 33.921 17.830  1.00 25.88 ? 184 LYS L C   1 
ATOM   3705 O O   . LYS C 3 184 ? -33.114 33.130 18.531  1.00 25.11 ? 184 LYS L O   1 
ATOM   3706 C CB  . LYS C 3 184 ? -31.145 35.788 18.866  1.00 22.45 ? 184 LYS L CB  1 
ATOM   3707 C CG  . LYS C 3 184 ? -32.254 35.970 19.889  1.00 24.13 ? 184 LYS L CG  1 
ATOM   3708 C CD  . LYS C 3 184 ? -32.616 37.442 20.006  1.00 29.23 ? 184 LYS L CD  1 
ATOM   3709 C CE  . LYS C 3 184 ? -33.624 37.682 21.121  1.00 31.25 ? 184 LYS L CE  1 
ATOM   3710 N NZ  . LYS C 3 184 ? -32.965 37.851 22.440  1.00 35.98 ? 184 LYS L NZ  1 
ATOM   3711 N N   . ALA C 3 185 ? -32.916 34.346 16.645  1.00 23.87 ? 185 ALA L N   1 
ATOM   3712 C CA  . ALA C 3 185 ? -34.256 33.996 16.189  1.00 25.66 ? 185 ALA L CA  1 
ATOM   3713 C C   . ALA C 3 185 ? -34.383 32.500 15.930  1.00 32.19 ? 185 ALA L C   1 
ATOM   3714 O O   . ALA C 3 185 ? -35.418 31.894 16.242  1.00 30.73 ? 185 ALA L O   1 
ATOM   3715 C CB  . ALA C 3 185 ? -34.599 34.792 14.932  1.00 28.32 ? 185 ALA L CB  1 
ATOM   3716 N N   . ASP C 3 186 ? -33.346 31.885 15.355  1.00 27.17 ? 186 ASP L N   1 
ATOM   3717 C CA  . ASP C 3 186 ? -33.377 30.442 15.133  1.00 27.14 ? 186 ASP L CA  1 
ATOM   3718 C C   . ASP C 3 186 ? -33.300 29.683 16.447  1.00 26.56 ? 186 ASP L C   1 
ATOM   3719 O O   . ASP C 3 186 ? -34.013 28.692 16.641  1.00 27.94 ? 186 ASP L O   1 
ATOM   3720 C CB  . ASP C 3 186 ? -32.231 30.023 14.211  1.00 26.30 ? 186 ASP L CB  1 
ATOM   3721 C CG  . ASP C 3 186 ? -32.603 30.094 12.746  1.00 31.23 ? 186 ASP L CG  1 
ATOM   3722 O OD1 . ASP C 3 186 ? -33.738 30.522 12.428  1.00 33.27 ? 186 ASP L OD1 1 
ATOM   3723 O OD2 . ASP C 3 186 ? -31.759 29.708 11.912  1.00 36.08 ? 186 ASP L OD2 1 
ATOM   3724 N N   . TYR C 3 187 ? -32.435 30.131 17.358  1.00 25.01 ? 187 TYR L N   1 
ATOM   3725 C CA  . TYR C 3 187 ? -32.310 29.476 18.655  1.00 26.78 ? 187 TYR L CA  1 
ATOM   3726 C C   . TYR C 3 187 ? -33.648 29.444 19.382  1.00 30.14 ? 187 TYR L C   1 
ATOM   3727 O O   . TYR C 3 187 ? -34.025 28.420 19.968  1.00 29.15 ? 187 TYR L O   1 
ATOM   3728 C CB  . TYR C 3 187 ? -31.250 30.191 19.495  1.00 23.22 ? 187 TYR L CB  1 
ATOM   3729 C CG  . TYR C 3 187 ? -31.098 29.662 20.911  1.00 22.42 ? 187 TYR L CG  1 
ATOM   3730 C CD1 . TYR C 3 187 ? -30.573 28.395 21.152  1.00 22.10 ? 187 TYR L CD1 1 
ATOM   3731 C CD2 . TYR C 3 187 ? -31.439 30.449 22.004  1.00 21.71 ? 187 TYR L CD2 1 
ATOM   3732 C CE1 . TYR C 3 187 ? -30.420 27.919 22.451  1.00 20.00 ? 187 TYR L CE1 1 
ATOM   3733 C CE2 . TYR C 3 187 ? -31.289 29.990 23.294  1.00 23.97 ? 187 TYR L CE2 1 
ATOM   3734 C CZ  . TYR C 3 187 ? -30.782 28.718 23.511  1.00 20.83 ? 187 TYR L CZ  1 
ATOM   3735 O OH  . TYR C 3 187 ? -30.628 28.270 24.803  1.00 22.63 ? 187 TYR L OH  1 
ATOM   3736 N N   . GLU C 3 188 ? -34.392 30.549 19.335  1.00 31.48 ? 188 GLU L N   1 
ATOM   3737 C CA  . GLU C 3 188 ? -35.633 30.621 20.087  1.00 33.80 ? 188 GLU L CA  1 
ATOM   3738 C C   . GLU C 3 188 ? -36.795 29.931 19.383  1.00 32.62 ? 188 GLU L C   1 
ATOM   3739 O O   . GLU C 3 188 ? -37.862 29.783 19.986  1.00 32.91 ? 188 GLU L O   1 
ATOM   3740 C CB  . GLU C 3 188 ? -35.946 32.085 20.411  1.00 31.14 ? 188 GLU L CB  1 
ATOM   3741 C CG  . GLU C 3 188 ? -35.223 32.531 21.676  1.00 33.52 ? 188 GLU L CG  1 
ATOM   3742 C CD  . GLU C 3 188 ? -35.017 34.033 21.790  1.00 38.02 ? 188 GLU L CD  1 
ATOM   3743 O OE1 . GLU C 3 188 ? -35.582 34.796 20.974  1.00 40.00 ? 188 GLU L OE1 1 
ATOM   3744 O OE2 . GLU C 3 188 ? -34.277 34.447 22.710  1.00 40.71 ? 188 GLU L OE2 1 
ATOM   3745 N N   . LYS C 3 189 ? -36.610 29.467 18.147  1.00 32.52 ? 189 LYS L N   1 
ATOM   3746 C CA  . LYS C 3 189 ? -37.637 28.640 17.521  1.00 33.77 ? 189 LYS L CA  1 
ATOM   3747 C C   . LYS C 3 189 ? -37.673 27.218 18.072  1.00 37.09 ? 189 LYS L C   1 
ATOM   3748 O O   . LYS C 3 189 ? -38.659 26.511 17.842  1.00 37.96 ? 189 LYS L O   1 
ATOM   3749 C CB  . LYS C 3 189 ? -37.438 28.567 16.005  1.00 31.13 ? 189 LYS L CB  1 
ATOM   3750 C CG  . LYS C 3 189 ? -37.666 29.874 15.283  1.00 34.10 ? 189 LYS L CG  1 
ATOM   3751 C CD  . LYS C 3 189 ? -37.845 29.655 13.794  1.00 39.32 ? 189 LYS L CD  1 
ATOM   3752 C CE  . LYS C 3 189 ? -38.070 30.980 13.076  1.00 41.86 ? 189 LYS L CE  1 
ATOM   3753 N NZ  . LYS C 3 189 ? -38.940 30.835 11.864  1.00 42.74 ? 189 LYS L NZ  1 
ATOM   3754 N N   . HIS C 3 190 ? -36.632 26.772 18.776  1.00 34.37 ? 190 HIS L N   1 
ATOM   3755 C CA  . HIS C 3 190 ? -36.512 25.376 19.173  1.00 31.08 ? 190 HIS L CA  1 
ATOM   3756 C C   . HIS C 3 190 ? -36.272 25.267 20.672  1.00 29.63 ? 190 HIS L C   1 
ATOM   3757 O O   . HIS C 3 190 ? -35.913 26.239 21.341  1.00 33.65 ? 190 HIS L O   1 
ATOM   3758 C CB  . HIS C 3 190 ? -35.389 24.684 18.407  1.00 30.39 ? 190 HIS L CB  1 
ATOM   3759 C CG  . HIS C 3 190 ? -35.457 24.886 16.927  1.00 35.60 ? 190 HIS L CG  1 
ATOM   3760 N ND1 . HIS C 3 190 ? -36.500 24.416 16.159  1.00 34.15 ? 190 HIS L ND1 1 
ATOM   3761 C CD2 . HIS C 3 190 ? -34.608 25.504 16.071  1.00 34.53 ? 190 HIS L CD2 1 
ATOM   3762 C CE1 . HIS C 3 190 ? -36.291 24.735 14.893  1.00 36.29 ? 190 HIS L CE1 1 
ATOM   3763 N NE2 . HIS C 3 190 ? -35.149 25.394 14.812  1.00 35.57 ? 190 HIS L NE2 1 
ATOM   3764 N N   . LYS C 3 191 ? -36.467 24.054 21.198  1.00 33.27 ? 191 LYS L N   1 
ATOM   3765 C CA  . LYS C 3 191 ? -36.426 23.800 22.635  1.00 30.69 ? 191 LYS L CA  1 
ATOM   3766 C C   . LYS C 3 191 ? -35.269 22.908 23.067  1.00 29.94 ? 191 LYS L C   1 
ATOM   3767 O O   . LYS C 3 191 ? -34.547 23.261 24.002  1.00 28.80 ? 191 LYS L O   1 
ATOM   3768 C CB  . LYS C 3 191 ? -37.759 23.178 23.111  1.00 36.16 ? 191 LYS L CB  1 
ATOM   3769 C CG  . LYS C 3 191 ? -38.806 24.184 23.633  1.00 39.47 ? 191 LYS L CG  1 
ATOM   3770 C CD  . LYS C 3 191 ? -39.323 25.105 22.522  1.00 40.89 ? 191 LYS L CD  1 
ATOM   3771 C CE  . LYS C 3 191 ? -40.604 25.850 22.917  1.00 37.89 ? 191 LYS L CE  1 
ATOM   3772 N NZ  . LYS C 3 191 ? -40.383 27.006 23.835  1.00 42.35 ? 191 LYS L NZ  1 
ATOM   3773 N N   . VAL C 3 192 ? -35.077 21.741 22.451  1.00 29.70 ? 192 VAL L N   1 
ATOM   3774 C CA  . VAL C 3 192 ? -34.109 20.765 22.952  1.00 28.81 ? 192 VAL L CA  1 
ATOM   3775 C C   . VAL C 3 192 ? -32.880 20.758 22.048  1.00 28.69 ? 192 VAL L C   1 
ATOM   3776 O O   . VAL C 3 192 ? -32.976 20.585 20.825  1.00 26.75 ? 192 VAL L O   1 
ATOM   3777 C CB  . VAL C 3 192 ? -34.729 19.364 23.103  1.00 28.67 ? 192 VAL L CB  1 
ATOM   3778 C CG1 . VAL C 3 192 ? -35.526 18.963 21.884  1.00 34.65 ? 192 VAL L CG1 1 
ATOM   3779 C CG2 . VAL C 3 192 ? -33.649 18.342 23.404  1.00 29.59 ? 192 VAL L CG2 1 
ATOM   3780 N N   . TYR C 3 193 ? -31.722 20.963 22.661  1.00 23.19 ? 193 TYR L N   1 
ATOM   3781 C CA  . TYR C 3 193 ? -30.449 21.066 21.964  1.00 26.51 ? 193 TYR L CA  1 
ATOM   3782 C C   . TYR C 3 193 ? -29.553 19.942 22.447  1.00 21.15 ? 193 TYR L C   1 
ATOM   3783 O O   . TYR C 3 193 ? -29.327 19.804 23.651  1.00 26.14 ? 193 TYR L O   1 
ATOM   3784 C CB  . TYR C 3 193 ? -29.805 22.433 22.213  1.00 23.48 ? 193 TYR L CB  1 
ATOM   3785 C CG  . TYR C 3 193 ? -30.515 23.524 21.454  1.00 25.79 ? 193 TYR L CG  1 
ATOM   3786 C CD1 . TYR C 3 193 ? -31.709 24.058 21.918  1.00 27.94 ? 193 TYR L CD1 1 
ATOM   3787 C CD2 . TYR C 3 193 ? -30.013 23.990 20.255  1.00 24.00 ? 193 TYR L CD2 1 
ATOM   3788 C CE1 . TYR C 3 193 ? -32.370 25.041 21.208  1.00 25.80 ? 193 TYR L CE1 1 
ATOM   3789 C CE2 . TYR C 3 193 ? -30.661 24.967 19.543  1.00 24.64 ? 193 TYR L CE2 1 
ATOM   3790 C CZ  . TYR C 3 193 ? -31.841 25.489 20.025  1.00 28.75 ? 193 TYR L CZ  1 
ATOM   3791 O OH  . TYR C 3 193 ? -32.491 26.469 19.315  1.00 30.84 ? 193 TYR L OH  1 
ATOM   3792 N N   . ALA C 3 194 ? -29.053 19.146 21.516  1.00 22.93 ? 194 ALA L N   1 
ATOM   3793 C CA  . ALA C 3 194 ? -28.364 17.911 21.845  1.00 23.86 ? 194 ALA L CA  1 
ATOM   3794 C C   . ALA C 3 194 ? -27.005 17.856 21.173  1.00 24.09 ? 194 ALA L C   1 
ATOM   3795 O O   . ALA C 3 194 ? -26.875 18.162 19.983  1.00 22.84 ? 194 ALA L O   1 
ATOM   3796 C CB  . ALA C 3 194 ? -29.185 16.697 21.416  1.00 22.93 ? 194 ALA L CB  1 
ATOM   3797 N N   . CYS C 3 195 ? -26.006 17.433 21.943  1.00 21.91 ? 195 CYS L N   1 
ATOM   3798 C CA  . CYS C 3 195 ? -24.692 17.064 21.429  1.00 21.63 ? 195 CYS L CA  1 
ATOM   3799 C C   . CYS C 3 195 ? -24.522 15.547 21.550  1.00 19.90 ? 195 CYS L C   1 
ATOM   3800 O O   . CYS C 3 195 ? -24.535 15.010 22.662  1.00 22.00 ? 195 CYS L O   1 
ATOM   3801 C CB  . CYS C 3 195 ? -23.608 17.809 22.209  1.00 20.91 ? 195 CYS L CB  1 
ATOM   3802 S SG  . CYS C 3 195 ? -21.971 17.463 21.703  1.00 28.44 ? 195 CYS L SG  1 
ATOM   3803 N N   . GLU C 3 196 ? -24.348 14.862 20.418  1.00 20.89 ? 196 GLU L N   1 
ATOM   3804 C CA  . GLU C 3 196 ? -24.206 13.404 20.378  1.00 22.73 ? 196 GLU L CA  1 
ATOM   3805 C C   . GLU C 3 196 ? -22.780 13.015 19.992  1.00 21.70 ? 196 GLU L C   1 
ATOM   3806 O O   . GLU C 3 196 ? -22.295 13.405 18.924  1.00 23.35 ? 196 GLU L O   1 
ATOM   3807 C CB  . GLU C 3 196 ? -25.193 12.773 19.391  1.00 26.52 ? 196 GLU L CB  1 
ATOM   3808 C CG  . GLU C 3 196 ? -24.936 11.278 19.153  1.00 29.15 ? 196 GLU L CG  1 
ATOM   3809 C CD  . GLU C 3 196 ? -26.155 10.540 18.628  1.00 37.25 ? 196 GLU L CD  1 
ATOM   3810 O OE1 . GLU C 3 196 ? -27.070 11.206 18.093  1.00 42.18 ? 196 GLU L OE1 1 
ATOM   3811 O OE2 . GLU C 3 196 ? -26.208 9.295  18.760  1.00 39.17 ? 196 GLU L OE2 1 
ATOM   3812 N N   . VAL C 3 197 ? -22.134 12.205 20.831  1.00 21.06 ? 197 VAL L N   1 
ATOM   3813 C CA  . VAL C 3 197 ? -20.708 11.909 20.711  1.00 22.46 ? 197 VAL L CA  1 
ATOM   3814 C C   . VAL C 3 197 ? -20.500 10.408 20.535  1.00 22.51 ? 197 VAL L C   1 
ATOM   3815 O O   . VAL C 3 197 ? -20.960 9.615  21.364  1.00 22.34 ? 197 VAL L O   1 
ATOM   3816 C CB  . VAL C 3 197 ? -19.931 12.406 21.945  1.00 22.00 ? 197 VAL L CB  1 
ATOM   3817 C CG1 . VAL C 3 197 ? -18.481 11.917 21.911  1.00 16.94 ? 197 VAL L CG1 1 
ATOM   3818 C CG2 . VAL C 3 197 ? -20.006 13.928 22.040  1.00 21.95 ? 197 VAL L CG2 1 
ATOM   3819 N N   . THR C 3 198 ? -19.771 10.023 19.489  1.00 22.83 ? 198 THR L N   1 
ATOM   3820 C CA  . THR C 3 198 ? -19.323 8.642  19.319  1.00 23.23 ? 198 THR L CA  1 
ATOM   3821 C C   . THR C 3 198 ? -17.804 8.582  19.447  1.00 22.48 ? 198 THR L C   1 
ATOM   3822 O O   . THR C 3 198 ? -17.088 9.390  18.837  1.00 24.05 ? 198 THR L O   1 
ATOM   3823 C CB  . THR C 3 198 ? -19.770 8.058  17.974  1.00 28.36 ? 198 THR L CB  1 
ATOM   3824 O OG1 . THR C 3 198 ? -18.841 8.431  16.957  1.00 34.89 ? 198 THR L OG1 1 
ATOM   3825 C CG2 . THR C 3 198 ? -21.145 8.558  17.589  1.00 20.92 ? 198 THR L CG2 1 
ATOM   3826 N N   . HIS C 3 199 ? -17.318 7.644  20.262  1.00 22.08 ? 199 HIS L N   1 
ATOM   3827 C CA  . HIS C 3 199 ? -15.896 7.525  20.557  1.00 19.75 ? 199 HIS L CA  1 
ATOM   3828 C C   . HIS C 3 199 ? -15.567 6.074  20.891  1.00 19.62 ? 199 HIS L C   1 
ATOM   3829 O O   . HIS C 3 199 ? -16.420 5.308  21.350  1.00 21.16 ? 199 HIS L O   1 
ATOM   3830 C CB  . HIS C 3 199 ? -15.469 8.441  21.719  1.00 19.78 ? 199 HIS L CB  1 
ATOM   3831 C CG  . HIS C 3 199 ? -14.001 8.400  22.009  1.00 19.81 ? 199 HIS L CG  1 
ATOM   3832 N ND1 . HIS C 3 199 ? -13.466 7.628  23.016  1.00 16.56 ? 199 HIS L ND1 1 
ATOM   3833 C CD2 . HIS C 3 199 ? -12.953 9.015  21.411  1.00 16.11 ? 199 HIS L CD2 1 
ATOM   3834 C CE1 . HIS C 3 199 ? -12.151 7.767  23.029  1.00 15.20 ? 199 HIS L CE1 1 
ATOM   3835 N NE2 . HIS C 3 199 ? -11.815 8.608  22.066  1.00 15.13 ? 199 HIS L NE2 1 
ATOM   3836 N N   . GLN C 3 200 ? -14.294 5.724  20.679  1.00 21.01 ? 200 GLN L N   1 
ATOM   3837 C CA  . GLN C 3 200 ? -13.803 4.376  20.960  1.00 19.35 ? 200 GLN L CA  1 
ATOM   3838 C C   . GLN C 3 200 ? -14.149 3.920  22.371  1.00 19.24 ? 200 GLN L C   1 
ATOM   3839 O O   . GLN C 3 200 ? -14.501 2.754  22.585  1.00 22.80 ? 200 GLN L O   1 
ATOM   3840 C CB  . GLN C 3 200 ? -12.287 4.337  20.750  1.00 18.38 ? 200 GLN L CB  1 
ATOM   3841 C CG  . GLN C 3 200 ? -11.672 2.948  20.870  1.00 19.97 ? 200 GLN L CG  1 
ATOM   3842 C CD  . GLN C 3 200 ? -12.116 2.051  19.743  1.00 21.78 ? 200 GLN L CD  1 
ATOM   3843 O OE1 . GLN C 3 200 ? -12.416 2.526  18.650  1.00 22.62 ? 200 GLN L OE1 1 
ATOM   3844 N NE2 . GLN C 3 200 ? -12.158 0.745  19.997  1.00 18.17 ? 200 GLN L NE2 1 
ATOM   3845 N N   . GLY C 3 201 ? -14.045 4.814  23.349  1.00 17.94 ? 201 GLY L N   1 
ATOM   3846 C CA  . GLY C 3 201 ? -14.305 4.440  24.722  1.00 18.79 ? 201 GLY L CA  1 
ATOM   3847 C C   . GLY C 3 201 ? -15.755 4.329  25.113  1.00 20.94 ? 201 GLY L C   1 
ATOM   3848 O O   . GLY C 3 201 ? -16.067 3.969  26.252  1.00 21.27 ? 201 GLY L O   1 
ATOM   3849 N N   . LEU C 3 202 ? -16.665 4.606  24.198  1.00 22.88 ? 202 LEU L N   1 
ATOM   3850 C CA  . LEU C 3 202 ? -18.088 4.625  24.502  1.00 26.47 ? 202 LEU L CA  1 
ATOM   3851 C C   . LEU C 3 202 ? -18.738 3.385  23.912  1.00 29.70 ? 202 LEU L C   1 
ATOM   3852 O O   . LEU C 3 202 ? -18.721 3.191  22.689  1.00 28.84 ? 202 LEU L O   1 
ATOM   3853 C CB  . LEU C 3 202 ? -18.754 5.886  23.959  1.00 25.50 ? 202 LEU L CB  1 
ATOM   3854 C CG  . LEU C 3 202 ? -18.311 7.166  24.660  1.00 23.34 ? 202 LEU L CG  1 
ATOM   3855 C CD1 . LEU C 3 202 ? -18.991 8.341  24.003  1.00 24.76 ? 202 LEU L CD1 1 
ATOM   3856 C CD2 . LEU C 3 202 ? -18.615 7.112  26.148  1.00 19.51 ? 202 LEU L CD2 1 
ATOM   3857 N N   . SER C 3 203 ? -19.287 2.543  24.792  1.00 35.40 ? 203 SER L N   1 
ATOM   3858 C CA  . SER C 3 203 ? -20.140 1.442  24.363  1.00 36.12 ? 203 SER L CA  1 
ATOM   3859 C C   . SER C 3 203 ? -21.265 1.969  23.483  1.00 38.91 ? 203 SER L C   1 
ATOM   3860 O O   . SER C 3 203 ? -21.347 1.658  22.289  1.00 38.21 ? 203 SER L O   1 
ATOM   3861 C CB  . SER C 3 203 ? -20.704 0.719  25.592  1.00 37.48 ? 203 SER L CB  1 
ATOM   3862 O OG  . SER C 3 203 ? -19.675 0.381  26.512  1.00 45.83 ? 203 SER L OG  1 
ATOM   3863 N N   . SER C 3 204 ? -22.122 2.804  24.066  1.00 39.07 ? 204 SER L N   1 
ATOM   3864 C CA  . SER C 3 204 ? -23.190 3.512  23.381  1.00 40.55 ? 204 SER L CA  1 
ATOM   3865 C C   . SER C 3 204 ? -22.818 4.980  23.231  1.00 34.07 ? 204 SER L C   1 
ATOM   3866 O O   . SER C 3 204 ? -22.350 5.591  24.203  1.00 36.51 ? 204 SER L O   1 
ATOM   3867 C CB  . SER C 3 204 ? -24.515 3.383  24.162  1.00 38.50 ? 204 SER L CB  1 
ATOM   3868 O OG  . SER C 3 204 ? -24.366 2.593  25.341  1.00 45.54 ? 204 SER L OG  1 
ATOM   3869 N N   . PRO C 3 205 ? -22.977 5.563  22.043  1.00 33.88 ? 205 PRO L N   1 
ATOM   3870 C CA  . PRO C 3 205 ? -22.824 7.018  21.896  1.00 32.81 ? 205 PRO L CA  1 
ATOM   3871 C C   . PRO C 3 205 ? -23.609 7.775  22.957  1.00 29.30 ? 205 PRO L C   1 
ATOM   3872 O O   . PRO C 3 205 ? -24.782 7.492  23.206  1.00 30.02 ? 205 PRO L O   1 
ATOM   3873 C CB  . PRO C 3 205 ? -23.373 7.290  20.490  1.00 29.28 ? 205 PRO L CB  1 
ATOM   3874 C CG  . PRO C 3 205 ? -23.416 5.952  19.794  1.00 31.65 ? 205 PRO L CG  1 
ATOM   3875 C CD  . PRO C 3 205 ? -22.990 4.876  20.744  1.00 32.52 ? 205 PRO L CD  1 
ATOM   3876 N N   . VAL C 3 206 ? -22.951 8.727  23.608  1.00 25.75 ? 206 VAL L N   1 
ATOM   3877 C CA  . VAL C 3 206 ? -23.601 9.516  24.650  1.00 26.31 ? 206 VAL L CA  1 
ATOM   3878 C C   . VAL C 3 206 ? -24.152 10.793 24.030  1.00 26.80 ? 206 VAL L C   1 
ATOM   3879 O O   . VAL C 3 206 ? -23.550 11.381 23.120  1.00 27.07 ? 206 VAL L O   1 
ATOM   3880 C CB  . VAL C 3 206 ? -22.641 9.824  25.823  1.00 26.56 ? 206 VAL L CB  1 
ATOM   3881 C CG1 . VAL C 3 206 ? -22.133 8.538  26.463  1.00 29.76 ? 206 VAL L CG1 1 
ATOM   3882 C CG2 . VAL C 3 206 ? -21.479 10.692 25.381  1.00 27.28 ? 206 VAL L CG2 1 
ATOM   3883 N N   . THR C 3 207 ? -25.328 11.198 24.497  1.00 23.94 ? 207 THR L N   1 
ATOM   3884 C CA  . THR C 3 207 ? -25.957 12.450 24.104  1.00 21.70 ? 207 THR L CA  1 
ATOM   3885 C C   . THR C 3 207 ? -26.100 13.327 25.336  1.00 23.84 ? 207 THR L C   1 
ATOM   3886 O O   . THR C 3 207 ? -26.629 12.877 26.355  1.00 26.43 ? 207 THR L O   1 
ATOM   3887 C CB  . THR C 3 207 ? -27.330 12.202 23.475  1.00 24.15 ? 207 THR L CB  1 
ATOM   3888 O OG1 . THR C 3 207 ? -27.161 11.538 22.214  1.00 25.51 ? 207 THR L OG1 1 
ATOM   3889 C CG2 . THR C 3 207 ? -28.063 13.527 23.267  1.00 24.42 ? 207 THR L CG2 1 
ATOM   3890 N N   . LYS C 3 208 ? -25.612 14.560 25.254  1.00 21.05 ? 208 LYS L N   1 
ATOM   3891 C CA  . LYS C 3 208 ? -25.847 15.562 26.283  1.00 19.59 ? 208 LYS L CA  1 
ATOM   3892 C C   . LYS C 3 208 ? -26.768 16.629 25.713  1.00 22.36 ? 208 LYS L C   1 
ATOM   3893 O O   . LYS C 3 208 ? -26.609 17.048 24.562  1.00 24.83 ? 208 LYS L O   1 
ATOM   3894 C CB  . LYS C 3 208 ? -24.538 16.191 26.773  1.00 20.45 ? 208 LYS L CB  1 
ATOM   3895 C CG  . LYS C 3 208 ? -23.660 15.253 27.601  1.00 23.27 ? 208 LYS L CG  1 
ATOM   3896 C CD  . LYS C 3 208 ? -24.438 14.560 28.727  1.00 24.08 ? 208 LYS L CD  1 
ATOM   3897 C CE  . LYS C 3 208 ? -23.612 14.495 29.998  1.00 27.84 ? 208 LYS L CE  1 
ATOM   3898 N NZ  . LYS C 3 208 ? -23.699 13.169 30.668  1.00 29.78 ? 208 LYS L NZ  1 
ATOM   3899 N N   . SER C 3 209 ? -27.740 17.067 26.507  1.00 24.48 ? 209 SER L N   1 
ATOM   3900 C CA  . SER C 3 209 ? -28.732 17.974 25.954  1.00 24.23 ? 209 SER L CA  1 
ATOM   3901 C C   . SER C 3 209 ? -29.292 18.870 27.042  1.00 22.61 ? 209 SER L C   1 
ATOM   3902 O O   . SER C 3 209 ? -29.122 18.619 28.237  1.00 21.95 ? 209 SER L O   1 
ATOM   3903 C CB  . SER C 3 209 ? -29.870 17.213 25.266  1.00 25.63 ? 209 SER L CB  1 
ATOM   3904 O OG  . SER C 3 209 ? -30.661 16.559 26.233  1.00 27.90 ? 209 SER L OG  1 
ATOM   3905 N N   . PHE C 3 210 ? -29.930 19.951 26.601  1.00 24.22 ? 210 PHE L N   1 
ATOM   3906 C CA  . PHE C 3 210 ? -30.687 20.827 27.481  1.00 26.52 ? 210 PHE L CA  1 
ATOM   3907 C C   . PHE C 3 210 ? -31.918 21.308 26.730  1.00 26.40 ? 210 PHE L C   1 
ATOM   3908 O O   . PHE C 3 210 ? -31.950 21.326 25.492  1.00 23.32 ? 210 PHE L O   1 
ATOM   3909 C CB  . PHE C 3 210 ? -29.855 22.022 27.977  1.00 24.63 ? 210 PHE L CB  1 
ATOM   3910 C CG  . PHE C 3 210 ? -29.424 22.969 26.872  1.00 24.79 ? 210 PHE L CG  1 
ATOM   3911 C CD1 . PHE C 3 210 ? -30.264 23.987 26.435  1.00 23.66 ? 210 PHE L CD1 1 
ATOM   3912 C CD2 . PHE C 3 210 ? -28.181 22.833 26.269  1.00 24.90 ? 210 PHE L CD2 1 
ATOM   3913 C CE1 . PHE C 3 210 ? -29.878 24.845 25.419  1.00 20.91 ? 210 PHE L CE1 1 
ATOM   3914 C CE2 . PHE C 3 210 ? -27.780 23.697 25.249  1.00 23.78 ? 210 PHE L CE2 1 
ATOM   3915 C CZ  . PHE C 3 210 ? -28.633 24.700 24.823  1.00 21.09 ? 210 PHE L CZ  1 
ATOM   3916 N N   . ASN C 3 211 ? -32.941 21.684 27.498  1.00 25.52 ? 211 ASN L N   1 
ATOM   3917 C CA  . ASN C 3 211 ? -34.121 22.360 26.972  1.00 27.89 ? 211 ASN L CA  1 
ATOM   3918 C C   . ASN C 3 211 ? -33.961 23.851 27.198  1.00 26.41 ? 211 ASN L C   1 
ATOM   3919 O O   . ASN C 3 211 ? -33.683 24.284 28.320  1.00 29.10 ? 211 ASN L O   1 
ATOM   3920 C CB  . ASN C 3 211 ? -35.405 21.874 27.646  1.00 29.54 ? 211 ASN L CB  1 
ATOM   3921 C CG  . ASN C 3 211 ? -35.578 20.386 27.555  1.00 32.41 ? 211 ASN L CG  1 
ATOM   3922 O OD1 . ASN C 3 211 ? -35.435 19.797 26.485  1.00 31.70 ? 211 ASN L OD1 1 
ATOM   3923 N ND2 . ASN C 3 211 ? -35.874 19.755 28.689  1.00 37.52 ? 211 ASN L ND2 1 
ATOM   3924 N N   . ARG C 3 212 ? -34.122 24.631 26.132  1.00 30.47 ? 212 ARG L N   1 
ATOM   3925 C CA  . ARG C 3 212 ? -34.021 26.081 26.248  1.00 29.33 ? 212 ARG L CA  1 
ATOM   3926 C C   . ARG C 3 212 ? -34.999 26.595 27.293  1.00 34.81 ? 212 ARG L C   1 
ATOM   3927 O O   . ARG C 3 212 ? -36.185 26.255 27.273  1.00 35.86 ? 212 ARG L O   1 
ATOM   3928 C CB  . ARG C 3 212 ? -34.296 26.737 24.897  1.00 28.42 ? 212 ARG L CB  1 
ATOM   3929 C CG  . ARG C 3 212 ? -34.265 28.261 24.924  1.00 31.33 ? 212 ARG L CG  1 
ATOM   3930 C CD  . ARG C 3 212 ? -34.505 28.839 23.529  1.00 31.22 ? 212 ARG L CD  1 
ATOM   3931 N NE  . ARG C 3 212 ? -35.687 28.274 22.887  1.00 35.20 ? 212 ARG L NE  1 
ATOM   3932 C CZ  . ARG C 3 212 ? -36.934 28.639 23.154  1.00 33.65 ? 212 ARG L CZ  1 
ATOM   3933 N NH1 . ARG C 3 212 ? -37.203 29.581 24.043  1.00 32.09 ? 212 ARG L NH1 1 
ATOM   3934 N NH2 . ARG C 3 212 ? -37.936 28.039 22.516  1.00 32.51 ? 212 ARG L NH2 1 
ATOM   3935 N N   . GLY C 3 213 ? -34.488 27.388 28.229  1.00 36.09 ? 213 GLY L N   1 
ATOM   3936 C CA  . GLY C 3 213 ? -35.321 28.009 29.232  1.00 41.00 ? 213 GLY L CA  1 
ATOM   3937 C C   . GLY C 3 213 ? -35.452 27.261 30.538  1.00 45.26 ? 213 GLY L C   1 
ATOM   3938 O O   . GLY C 3 213 ? -36.349 27.585 31.326  1.00 54.73 ? 213 GLY L O   1 
ATOM   3939 N N   . GLU C 3 214 ? -34.592 26.282 30.802  1.00 42.92 ? 214 GLU L N   1 
ATOM   3940 C CA  . GLU C 3 214 ? -34.642 25.512 32.035  1.00 45.64 ? 214 GLU L CA  1 
ATOM   3941 C C   . GLU C 3 214 ? -33.316 25.624 32.775  1.00 49.59 ? 214 GLU L C   1 
ATOM   3942 O O   . GLU C 3 214 ? -32.253 25.752 32.157  1.00 48.34 ? 214 GLU L O   1 
ATOM   3943 C CB  . GLU C 3 214 ? -34.979 24.047 31.744  1.00 41.22 ? 214 GLU L CB  1 
ATOM   3944 C CG  . GLU C 3 214 ? -36.091 23.911 30.722  1.00 40.84 ? 214 GLU L CG  1 
ATOM   3945 C CD  . GLU C 3 214 ? -36.900 22.642 30.887  1.00 45.59 ? 214 GLU L CD  1 
ATOM   3946 O OE1 . GLU C 3 214 ? -36.345 21.645 31.402  1.00 47.58 ? 214 GLU L OE1 1 
ATOM   3947 O OE2 . GLU C 3 214 ? -38.091 22.653 30.500  1.00 45.67 ? 214 GLU L OE2 1 
ATOM   3948 N N   . CYS C 3 215 ? -33.391 25.572 34.105  1.00 51.74 ? 215 CYS L N   1 
ATOM   3949 C CA  . CYS C 3 215 ? -32.218 25.747 34.964  1.00 50.92 ? 215 CYS L CA  1 
ATOM   3950 C C   . CYS C 3 215 ? -32.576 25.578 36.444  1.00 53.88 ? 215 CYS L C   1 
ATOM   3951 O O   . CYS C 3 215 ? -31.952 26.176 37.331  1.00 56.65 ? 215 CYS L O   1 
ATOM   3952 C CB  . CYS C 3 215 ? -31.584 27.122 34.732  1.00 52.34 ? 215 CYS L CB  1 
ATOM   3953 S SG  . CYS C 3 215 ? -32.756 28.523 34.718  1.00 90.98 ? 215 CYS L SG  1 
HETATM 3954 O O   . HOH D 4 .   ? 23.540  2.222  -6.669  1.00 34.36 ? 201 HOH C O   1 
HETATM 3955 O O   . HOH D 4 .   ? 30.019  4.642  -8.369  1.00 33.37 ? 202 HOH C O   1 
HETATM 3956 O O   . HOH D 4 .   ? 16.536  13.245 -10.446 1.00 20.41 ? 203 HOH C O   1 
HETATM 3957 O O   . HOH D 4 .   ? 24.340  26.824 -14.244 1.00 20.26 ? 204 HOH C O   1 
HETATM 3958 O O   . HOH D 4 .   ? 43.517  23.610 -13.920 1.00 40.64 ? 205 HOH C O   1 
HETATM 3959 O O   . HOH D 4 .   ? 26.300  20.514 -10.367 1.00 15.72 ? 206 HOH C O   1 
HETATM 3960 O O   . HOH D 4 .   ? 14.647  20.504 -17.618 1.00 27.07 ? 207 HOH C O   1 
HETATM 3961 O O   . HOH D 4 .   ? 35.061  26.702 -12.270 1.00 22.00 ? 208 HOH C O   1 
HETATM 3962 O O   . HOH D 4 .   ? 19.820  20.814 -5.613  1.00 12.01 ? 209 HOH C O   1 
HETATM 3963 O O   . HOH D 4 .   ? 28.773  27.921 -20.068 1.00 21.67 ? 210 HOH C O   1 
HETATM 3964 O O   . HOH D 4 .   ? 29.379  22.874 -4.697  1.00 22.40 ? 211 HOH C O   1 
HETATM 3965 O O   . HOH D 4 .   ? 27.155  21.856 -6.366  1.00 15.75 ? 212 HOH C O   1 
HETATM 3966 O O   . HOH D 4 .   ? 23.448  8.519  -5.758  1.00 29.42 ? 213 HOH C O   1 
HETATM 3967 O O   . HOH D 4 .   ? 34.370  22.884 -0.606  1.00 25.28 ? 214 HOH C O   1 
HETATM 3968 O O   . HOH D 4 .   ? 17.128  8.092  -14.595 1.00 32.28 ? 215 HOH C O   1 
HETATM 3969 O O   . HOH D 4 .   ? 30.644  21.523 2.927   1.00 31.21 ? 216 HOH C O   1 
HETATM 3970 O O   . HOH D 4 .   ? 26.368  28.119 -10.897 1.00 25.60 ? 217 HOH C O   1 
HETATM 3971 O O   . HOH D 4 .   ? 10.104  24.107 -20.021 1.00 32.15 ? 218 HOH C O   1 
HETATM 3972 O O   . HOH D 4 .   ? 38.038  21.917 -18.415 1.00 35.38 ? 219 HOH C O   1 
HETATM 3973 O O   . HOH D 4 .   ? 41.058  23.877 -15.824 1.00 36.59 ? 220 HOH C O   1 
HETATM 3974 O O   . HOH D 4 .   ? 33.004  20.296 -24.290 1.00 38.08 ? 221 HOH C O   1 
HETATM 3975 O O   . HOH D 4 .   ? 40.690  23.607 -17.900 1.00 38.61 ? 222 HOH C O   1 
HETATM 3976 O O   . HOH D 4 .   ? 35.028  21.023 -24.088 1.00 37.25 ? 223 HOH C O   1 
HETATM 3977 O O   . HOH D 4 .   ? 38.484  8.730  1.414   1.00 37.99 ? 224 HOH C O   1 
HETATM 3978 O O   . HOH D 4 .   ? 32.013  21.859 -19.703 1.00 31.25 ? 225 HOH C O   1 
HETATM 3979 O O   . HOH D 4 .   ? 20.640  4.819  -5.940  1.00 30.42 ? 226 HOH C O   1 
HETATM 3980 O O   . HOH D 4 .   ? 39.279  10.112 3.469   1.00 43.86 ? 227 HOH C O   1 
HETATM 3981 O O   . HOH D 4 .   ? 32.064  20.982 -17.735 1.00 23.66 ? 228 HOH C O   1 
HETATM 3982 O O   . HOH D 4 .   ? 21.986  1.209  -8.904  1.00 38.04 ? 229 HOH C O   1 
HETATM 3983 O O   . HOH D 4 .   ? 40.856  25.537 -14.282 1.00 31.72 ? 230 HOH C O   1 
HETATM 3984 O O   . HOH D 4 .   ? 20.732  0.052  -6.974  1.00 39.42 ? 231 HOH C O   1 
HETATM 3985 O O   . HOH E 4 .   ? 22.045  37.032 4.963   1.00 35.60 ? 301 HOH H O   1 
HETATM 3986 O O   . HOH E 4 .   ? -15.149 38.893 6.996   1.00 22.73 ? 302 HOH H O   1 
HETATM 3987 O O   . HOH E 4 .   ? -4.191  35.007 12.834  1.00 28.06 ? 303 HOH H O   1 
HETATM 3988 O O   . HOH E 4 .   ? -4.276  27.400 43.409  1.00 28.30 ? 304 HOH H O   1 
HETATM 3989 O O   . HOH E 4 .   ? -12.581 43.776 12.641  1.00 24.11 ? 305 HOH H O   1 
HETATM 3990 O O   . HOH E 4 .   ? -12.701 29.674 8.769   1.00 29.89 ? 306 HOH H O   1 
HETATM 3991 O O   . HOH E 4 .   ? 28.371  34.333 1.883   1.00 25.58 ? 307 HOH H O   1 
HETATM 3992 O O   . HOH E 4 .   ? -19.617 39.985 18.523  1.00 24.27 ? 308 HOH H O   1 
HETATM 3993 O O   . HOH E 4 .   ? -15.526 27.873 21.410  1.00 19.97 ? 309 HOH H O   1 
HETATM 3994 O O   . HOH E 4 .   ? -1.149  22.922 37.478  1.00 24.95 ? 310 HOH H O   1 
HETATM 3995 O O   . HOH E 4 .   ? 15.136  26.345 12.640  1.00 27.08 ? 311 HOH H O   1 
HETATM 3996 O O   . HOH E 4 .   ? -4.838  24.904 22.889  1.00 27.33 ? 312 HOH H O   1 
HETATM 3997 O O   . HOH E 4 .   ? -18.182 36.534 14.111  1.00 20.74 ? 313 HOH H O   1 
HETATM 3998 O O   . HOH E 4 .   ? -13.024 46.311 13.578  1.00 22.26 ? 314 HOH H O   1 
HETATM 3999 O O   . HOH E 4 .   ? -6.234  43.341 8.277   1.00 17.71 ? 315 HOH H O   1 
HETATM 4000 O O   . HOH E 4 .   ? 10.826  35.320 -11.515 1.00 18.07 ? 316 HOH H O   1 
HETATM 4001 O O   . HOH E 4 .   ? 0.272   26.212 1.910   1.00 21.74 ? 317 HOH H O   1 
HETATM 4002 O O   . HOH E 4 .   ? -0.853  40.020 17.086  1.00 25.68 ? 318 HOH H O   1 
HETATM 4003 O O   . HOH E 4 .   ? -9.354  37.179 9.282   1.00 13.39 ? 319 HOH H O   1 
HETATM 4004 O O   . HOH E 4 .   ? -13.559 40.240 9.923   1.00 20.69 ? 320 HOH H O   1 
HETATM 4005 O O   . HOH E 4 .   ? 1.841   23.405 -4.311  1.00 13.79 ? 321 HOH H O   1 
HETATM 4006 O O   . HOH E 4 .   ? -4.988  29.040 29.449  1.00 19.61 ? 322 HOH H O   1 
HETATM 4007 O O   . HOH E 4 .   ? -3.071  39.277 23.336  1.00 22.56 ? 323 HOH H O   1 
HETATM 4008 O O   . HOH E 4 .   ? -22.228 32.051 44.451  1.00 24.95 ? 324 HOH H O   1 
HETATM 4009 O O   . HOH E 4 .   ? 2.634   19.766 0.149   1.00 17.57 ? 325 HOH H O   1 
HETATM 4010 O O   . HOH E 4 .   ? -8.149  26.079 14.996  1.00 27.23 ? 326 HOH H O   1 
HETATM 4011 O O   . HOH E 4 .   ? -10.188 19.148 32.409  1.00 17.59 ? 327 HOH H O   1 
HETATM 4012 O O   . HOH E 4 .   ? 21.254  19.362 8.245   1.00 23.12 ? 328 HOH H O   1 
HETATM 4013 O O   . HOH E 4 .   ? -3.420  18.409 9.380   1.00 29.80 ? 329 HOH H O   1 
HETATM 4014 O O   . HOH E 4 .   ? 7.008   26.749 13.099  1.00 26.71 ? 330 HOH H O   1 
HETATM 4015 O O   . HOH E 4 .   ? -5.027  21.876 27.033  1.00 24.72 ? 331 HOH H O   1 
HETATM 4016 O O   . HOH E 4 .   ? -5.186  32.325 10.653  1.00 24.53 ? 332 HOH H O   1 
HETATM 4017 O O   . HOH E 4 .   ? 15.450  43.176 3.990   1.00 29.79 ? 333 HOH H O   1 
HETATM 4018 O O   . HOH E 4 .   ? 19.378  43.744 -1.675  1.00 30.11 ? 334 HOH H O   1 
HETATM 4019 O O   . HOH E 4 .   ? -4.912  24.550 39.944  1.00 20.04 ? 335 HOH H O   1 
HETATM 4020 O O   . HOH E 4 .   ? 17.843  43.393 2.722   1.00 25.40 ? 336 HOH H O   1 
HETATM 4021 O O   . HOH E 4 .   ? 1.047   27.557 10.071  1.00 20.39 ? 337 HOH H O   1 
HETATM 4022 O O   . HOH E 4 .   ? -1.541  25.164 -2.518  1.00 22.45 ? 338 HOH H O   1 
HETATM 4023 O O   . HOH E 4 .   ? 17.493  19.452 -4.532  1.00 11.78 ? 339 HOH H O   1 
HETATM 4024 O O   . HOH E 4 .   ? -5.793  33.666 19.512  1.00 20.38 ? 340 HOH H O   1 
HETATM 4025 O O   . HOH E 4 .   ? 11.299  42.263 3.810   1.00 24.29 ? 341 HOH H O   1 
HETATM 4026 O O   . HOH E 4 .   ? -10.884 17.710 36.835  1.00 31.17 ? 342 HOH H O   1 
HETATM 4027 O O   . HOH E 4 .   ? 6.124   34.061 -10.558 1.00 20.36 ? 343 HOH H O   1 
HETATM 4028 O O   . HOH E 4 .   ? -11.761 27.542 19.664  1.00 17.95 ? 344 HOH H O   1 
HETATM 4029 O O   . HOH E 4 .   ? -8.288  44.244 0.230   1.00 20.73 ? 345 HOH H O   1 
HETATM 4030 O O   . HOH E 4 .   ? 28.342  22.516 2.332   1.00 18.99 ? 346 HOH H O   1 
HETATM 4031 O O   . HOH E 4 .   ? 4.484   23.003 -4.117  1.00 13.74 ? 347 HOH H O   1 
HETATM 4032 O O   . HOH E 4 .   ? 15.841  38.883 8.126   1.00 20.53 ? 348 HOH H O   1 
HETATM 4033 O O   . HOH E 4 .   ? -4.186  29.558 5.138   1.00 19.15 ? 349 HOH H O   1 
HETATM 4034 O O   . HOH E 4 .   ? -2.387  26.934 39.458  1.00 23.05 ? 350 HOH H O   1 
HETATM 4035 O O   . HOH E 4 .   ? -5.032  36.526 30.592  1.00 20.43 ? 351 HOH H O   1 
HETATM 4036 O O   . HOH E 4 .   ? -0.491  31.904 -8.430  1.00 19.43 ? 352 HOH H O   1 
HETATM 4037 O O   . HOH E 4 .   ? -4.195  37.114 13.709  1.00 23.30 ? 353 HOH H O   1 
HETATM 4038 O O   . HOH E 4 .   ? -5.011  29.720 18.481  1.00 23.70 ? 354 HOH H O   1 
HETATM 4039 O O   . HOH E 4 .   ? 11.840  39.083 -5.160  1.00 21.57 ? 355 HOH H O   1 
HETATM 4040 O O   . HOH E 4 .   ? -9.515  21.804 38.555  1.00 24.77 ? 356 HOH H O   1 
HETATM 4041 O O   . HOH E 4 .   ? 10.186  30.401 -13.546 1.00 28.57 ? 357 HOH H O   1 
HETATM 4042 O O   . HOH E 4 .   ? 24.222  34.952 12.552  1.00 22.76 ? 358 HOH H O   1 
HETATM 4043 O O   . HOH E 4 .   ? -3.864  24.183 30.332  1.00 26.90 ? 359 HOH H O   1 
HETATM 4044 O O   . HOH E 4 .   ? 29.648  27.241 2.624   1.00 18.28 ? 360 HOH H O   1 
HETATM 4045 O O   . HOH E 4 .   ? 7.101   42.993 4.721   1.00 23.92 ? 361 HOH H O   1 
HETATM 4046 O O   . HOH E 4 .   ? 27.736  25.110 -5.269  1.00 15.84 ? 362 HOH H O   1 
HETATM 4047 O O   . HOH E 4 .   ? -5.458  26.640 7.491   1.00 22.55 ? 363 HOH H O   1 
HETATM 4048 O O   . HOH E 4 .   ? 13.003  38.319 12.210  1.00 28.39 ? 364 HOH H O   1 
HETATM 4049 O O   . HOH E 4 .   ? 4.802   37.671 11.504  1.00 24.63 ? 365 HOH H O   1 
HETATM 4050 O O   . HOH E 4 .   ? -17.404 30.729 17.337  1.00 17.09 ? 366 HOH H O   1 
HETATM 4051 O O   . HOH E 4 .   ? 22.768  23.990 -3.199  1.00 10.85 ? 367 HOH H O   1 
HETATM 4052 O O   . HOH E 4 .   ? -8.641  36.040 -0.269  1.00 22.45 ? 368 HOH H O   1 
HETATM 4053 O O   . HOH E 4 .   ? 0.554   24.483 3.903   1.00 15.29 ? 369 HOH H O   1 
HETATM 4054 O O   . HOH E 4 .   ? -14.964 43.969 23.156  1.00 26.67 ? 370 HOH H O   1 
HETATM 4055 O O   . HOH E 4 .   ? -7.064  35.853 9.554   1.00 17.03 ? 371 HOH H O   1 
HETATM 4056 O O   . HOH E 4 .   ? -6.978  34.971 7.216   1.00 21.83 ? 372 HOH H O   1 
HETATM 4057 O O   . HOH E 4 .   ? 2.821   47.284 -4.015  1.00 40.79 ? 373 HOH H O   1 
HETATM 4058 O O   . HOH E 4 .   ? 12.361  34.388 11.702  1.00 22.54 ? 374 HOH H O   1 
HETATM 4059 O O   . HOH E 4 .   ? -23.366 29.256 29.514  1.00 22.11 ? 375 HOH H O   1 
HETATM 4060 O O   . HOH E 4 .   ? -9.635  28.027 12.085  1.00 21.71 ? 376 HOH H O   1 
HETATM 4061 O O   . HOH E 4 .   ? -5.385  29.117 22.387  1.00 17.17 ? 377 HOH H O   1 
HETATM 4062 O O   . HOH E 4 .   ? 14.186  37.491 -13.202 1.00 30.77 ? 378 HOH H O   1 
HETATM 4063 O O   . HOH E 4 .   ? -9.467  33.517 -1.352  1.00 27.00 ? 379 HOH H O   1 
HETATM 4064 O O   . HOH E 4 .   ? 22.335  21.208 -4.402  1.00 13.70 ? 380 HOH H O   1 
HETATM 4065 O O   . HOH E 4 .   ? -2.514  33.506 11.044  1.00 21.70 ? 381 HOH H O   1 
HETATM 4066 O O   . HOH E 4 .   ? 7.817   24.061 -10.468 1.00 24.40 ? 382 HOH H O   1 
HETATM 4067 O O   . HOH E 4 .   ? -10.255 38.475 5.155   1.00 19.54 ? 383 HOH H O   1 
HETATM 4068 O O   . HOH E 4 .   ? 17.766  20.789 9.284   1.00 13.90 ? 384 HOH H O   1 
HETATM 4069 O O   . HOH E 4 .   ? 27.569  34.720 -1.078  1.00 19.24 ? 385 HOH H O   1 
HETATM 4070 O O   . HOH E 4 .   ? 26.607  31.649 -7.467  1.00 23.67 ? 386 HOH H O   1 
HETATM 4071 O O   . HOH E 4 .   ? -1.945  29.636 -3.137  1.00 26.57 ? 387 HOH H O   1 
HETATM 4072 O O   . HOH E 4 .   ? 26.400  36.403 5.731   1.00 21.97 ? 388 HOH H O   1 
HETATM 4073 O O   . HOH E 4 .   ? 14.201  32.017 -14.154 1.00 24.93 ? 389 HOH H O   1 
HETATM 4074 O O   . HOH E 4 .   ? -21.288 31.052 26.084  1.00 20.70 ? 390 HOH H O   1 
HETATM 4075 O O   . HOH E 4 .   ? -0.382  30.099 36.510  1.00 22.28 ? 391 HOH H O   1 
HETATM 4076 O O   . HOH E 4 .   ? -3.916  31.598 27.038  1.00 20.61 ? 392 HOH H O   1 
HETATM 4077 O O   . HOH E 4 .   ? -2.252  27.111 1.468   1.00 21.37 ? 393 HOH H O   1 
HETATM 4078 O O   . HOH E 4 .   ? 27.786  24.964 5.689   1.00 18.40 ? 394 HOH H O   1 
HETATM 4079 O O   . HOH E 4 .   ? 1.186   24.341 -6.760  1.00 18.19 ? 395 HOH H O   1 
HETATM 4080 O O   . HOH E 4 .   ? 26.298  20.887 1.492   1.00 20.41 ? 396 HOH H O   1 
HETATM 4081 O O   . HOH E 4 .   ? 28.332  34.524 7.007   1.00 20.28 ? 397 HOH H O   1 
HETATM 4082 O O   . HOH E 4 .   ? 29.000  33.701 -7.366  1.00 24.74 ? 398 HOH H O   1 
HETATM 4083 O O   . HOH E 4 .   ? -4.654  24.740 27.878  1.00 18.22 ? 399 HOH H O   1 
HETATM 4084 O O   . HOH E 4 .   ? 18.545  29.362 11.354  1.00 25.94 ? 400 HOH H O   1 
HETATM 4085 O O   . HOH E 4 .   ? 3.618   23.206 -9.041  1.00 18.34 ? 401 HOH H O   1 
HETATM 4086 O O   . HOH E 4 .   ? 27.399  22.979 5.571   1.00 24.31 ? 402 HOH H O   1 
HETATM 4087 O O   . HOH E 4 .   ? 8.968   27.353 -12.435 1.00 25.22 ? 403 HOH H O   1 
HETATM 4088 O O   . HOH E 4 .   ? -6.508  32.296 6.099   1.00 23.56 ? 404 HOH H O   1 
HETATM 4089 O O   . HOH E 4 .   ? -4.631  29.940 34.675  1.00 17.83 ? 405 HOH H O   1 
HETATM 4090 O O   . HOH E 4 .   ? 17.117  23.166 10.098  1.00 22.72 ? 406 HOH H O   1 
HETATM 4091 O O   . HOH E 4 .   ? -19.251 35.813 6.876   1.00 22.69 ? 407 HOH H O   1 
HETATM 4092 O O   . HOH E 4 .   ? 1.249   43.001 11.261  1.00 23.18 ? 408 HOH H O   1 
HETATM 4093 O O   . HOH E 4 .   ? -4.343  43.395 -6.910  1.00 36.94 ? 409 HOH H O   1 
HETATM 4094 O O   . HOH E 4 .   ? 24.982  33.206 14.580  1.00 27.89 ? 410 HOH H O   1 
HETATM 4095 O O   . HOH E 4 .   ? 7.061   40.962 -8.117  1.00 22.90 ? 411 HOH H O   1 
HETATM 4096 O O   . HOH E 4 .   ? 18.094  37.099 -8.019  1.00 17.74 ? 412 HOH H O   1 
HETATM 4097 O O   . HOH E 4 .   ? -8.730  28.425 42.498  1.00 28.87 ? 413 HOH H O   1 
HETATM 4098 O O   . HOH E 4 .   ? -17.964 30.483 11.199  1.00 23.97 ? 414 HOH H O   1 
HETATM 4099 O O   . HOH E 4 .   ? 6.489   44.824 2.376   1.00 27.00 ? 415 HOH H O   1 
HETATM 4100 O O   . HOH E 4 .   ? -12.412 34.050 7.215   1.00 28.42 ? 416 HOH H O   1 
HETATM 4101 O O   . HOH E 4 .   ? 6.252   35.974 12.708  1.00 25.29 ? 417 HOH H O   1 
HETATM 4102 O O   . HOH E 4 .   ? 0.679   25.122 11.527  1.00 26.43 ? 418 HOH H O   1 
HETATM 4103 O O   . HOH E 4 .   ? -11.725 17.750 39.369  1.00 35.96 ? 419 HOH H O   1 
HETATM 4104 O O   . HOH E 4 .   ? -4.845  32.164 21.279  1.00 30.45 ? 420 HOH H O   1 
HETATM 4105 O O   . HOH E 4 .   ? -11.122 24.234 41.993  1.00 30.89 ? 421 HOH H O   1 
HETATM 4106 O O   . HOH E 4 .   ? 26.014  18.494 1.370   1.00 25.12 ? 422 HOH H O   1 
HETATM 4107 O O   . HOH E 4 .   ? -3.000  27.217 -0.859  1.00 21.86 ? 423 HOH H O   1 
HETATM 4108 O O   . HOH E 4 .   ? -21.162 36.568 37.724  1.00 24.14 ? 424 HOH H O   1 
HETATM 4109 O O   . HOH E 4 .   ? -6.575  51.196 22.728  1.00 37.39 ? 425 HOH H O   1 
HETATM 4110 O O   . HOH E 4 .   ? -4.793  53.251 23.670  1.00 37.39 ? 426 HOH H O   1 
HETATM 4111 O O   . HOH E 4 .   ? -18.370 41.475 20.182  1.00 18.31 ? 427 HOH H O   1 
HETATM 4112 O O   . HOH E 4 .   ? 16.362  38.663 -9.629  1.00 25.77 ? 428 HOH H O   1 
HETATM 4113 O O   . HOH E 4 .   ? -0.967  23.193 40.715  1.00 26.61 ? 429 HOH H O   1 
HETATM 4114 O O   . HOH E 4 .   ? 5.140   22.765 -11.457 1.00 27.28 ? 430 HOH H O   1 
HETATM 4115 O O   . HOH E 4 .   ? 31.754  32.752 2.900   1.00 24.29 ? 431 HOH H O   1 
HETATM 4116 O O   . HOH E 4 .   ? -9.776  36.000 6.804   1.00 22.02 ? 432 HOH H O   1 
HETATM 4117 O O   . HOH E 4 .   ? 6.554   26.873 -13.852 1.00 29.54 ? 433 HOH H O   1 
HETATM 4118 O O   . HOH E 4 .   ? 2.181   38.482 12.696  1.00 27.20 ? 434 HOH H O   1 
HETATM 4119 O O   . HOH E 4 .   ? 1.480   41.318 13.123  1.00 28.70 ? 435 HOH H O   1 
HETATM 4120 O O   . HOH E 4 .   ? -0.513  40.467 14.493  1.00 33.58 ? 436 HOH H O   1 
HETATM 4121 O O   . HOH E 4 .   ? 0.666   21.206 -3.851  1.00 25.52 ? 437 HOH H O   1 
HETATM 4122 O O   . HOH E 4 .   ? 11.028  40.934 -6.815  1.00 30.06 ? 438 HOH H O   1 
HETATM 4123 O O   . HOH E 4 .   ? 0.353   21.302 -0.733  1.00 27.01 ? 439 HOH H O   1 
HETATM 4124 O O   . HOH E 4 .   ? -1.386  31.374 12.137  1.00 23.13 ? 440 HOH H O   1 
HETATM 4125 O O   . HOH E 4 .   ? -3.069  25.100 44.177  1.00 24.99 ? 441 HOH H O   1 
HETATM 4126 O O   . HOH E 4 .   ? -23.574 35.339 36.395  1.00 34.93 ? 442 HOH H O   1 
HETATM 4127 O O   . HOH E 4 .   ? -6.920  23.509 41.635  1.00 22.71 ? 443 HOH H O   1 
HETATM 4128 O O   . HOH E 4 .   ? -1.685  18.994 2.372   1.00 35.90 ? 444 HOH H O   1 
HETATM 4129 O O   . HOH E 4 .   ? -6.843  28.499 7.975   1.00 28.82 ? 445 HOH H O   1 
HETATM 4130 O O   . HOH E 4 .   ? -9.512  22.584 40.893  1.00 27.39 ? 446 HOH H O   1 
HETATM 4131 O O   . HOH E 4 .   ? -3.777  16.471 10.119  1.00 34.99 ? 447 HOH H O   1 
HETATM 4132 O O   . HOH E 4 .   ? -3.264  26.015 32.651  1.00 29.27 ? 448 HOH H O   1 
HETATM 4133 O O   . HOH E 4 .   ? 11.572  33.995 -13.999 1.00 26.84 ? 449 HOH H O   1 
HETATM 4134 O O   . HOH E 4 .   ? 31.388  34.618 1.627   1.00 28.00 ? 450 HOH H O   1 
HETATM 4135 O O   . HOH E 4 .   ? 0.617   29.566 12.179  1.00 24.49 ? 451 HOH H O   1 
HETATM 4136 O O   . HOH E 4 .   ? 1.576   30.754 13.841  1.00 27.72 ? 452 HOH H O   1 
HETATM 4137 O O   . HOH F 4 .   ? 6.245   14.322 -13.360 1.00 35.74 ? 301 HOH L O   1 
HETATM 4138 O O   . HOH F 4 .   ? -28.952 11.772 19.765  1.00 38.00 ? 302 HOH L O   1 
HETATM 4139 O O   . HOH F 4 .   ? -14.637 14.054 13.903  1.00 26.72 ? 303 HOH L O   1 
HETATM 4140 O O   . HOH F 4 .   ? 16.958  13.798 17.219  1.00 27.70 ? 304 HOH L O   1 
HETATM 4141 O O   . HOH F 4 .   ? -4.546  17.585 18.430  1.00 22.03 ? 305 HOH L O   1 
HETATM 4142 O O   . HOH F 4 .   ? -5.307  8.569  16.258  1.00 29.21 ? 306 HOH L O   1 
HETATM 4143 O O   . HOH F 4 .   ? 15.000  15.912 19.630  1.00 29.56 ? 307 HOH L O   1 
HETATM 4144 O O   . HOH F 4 .   ? -41.323 29.271 24.160  1.00 38.47 ? 308 HOH L O   1 
HETATM 4145 O O   . HOH F 4 .   ? 4.886   18.281 15.614  1.00 24.68 ? 309 HOH L O   1 
HETATM 4146 O O   . HOH F 4 .   ? 3.533   15.210 -2.569  1.00 16.41 ? 310 HOH L O   1 
HETATM 4147 O O   . HOH F 4 .   ? -31.299 30.008 26.501  1.00 32.63 ? 311 HOH L O   1 
HETATM 4148 O O   . HOH F 4 .   ? -3.829  19.586 27.772  1.00 23.79 ? 312 HOH L O   1 
HETATM 4149 O O   . HOH F 4 .   ? 4.537   10.829 -11.084 1.00 30.65 ? 313 HOH L O   1 
HETATM 4150 O O   . HOH F 4 .   ? 0.209   17.526 -13.212 1.00 41.12 ? 314 HOH L O   1 
HETATM 4151 O O   . HOH F 4 .   ? 24.695  6.931  12.257  1.00 38.90 ? 315 HOH L O   1 
HETATM 4152 O O   . HOH F 4 .   ? 20.019  5.024  7.634   1.00 21.98 ? 316 HOH L O   1 
HETATM 4153 O O   . HOH F 4 .   ? 17.789  3.726  -2.709  1.00 21.84 ? 317 HOH L O   1 
HETATM 4154 O O   . HOH F 4 .   ? -1.865  17.159 16.433  1.00 31.42 ? 318 HOH L O   1 
HETATM 4155 O O   . HOH F 4 .   ? -25.238 42.332 17.324  1.00 35.78 ? 319 HOH L O   1 
HETATM 4156 O O   . HOH F 4 .   ? -20.096 31.066 17.898  1.00 22.89 ? 320 HOH L O   1 
HETATM 4157 O O   . HOH F 4 .   ? 3.771   19.348 11.169  1.00 15.75 ? 321 HOH L O   1 
HETATM 4158 O O   . HOH F 4 .   ? -12.621 6.995  18.450  1.00 22.43 ? 322 HOH L O   1 
HETATM 4159 O O   . HOH F 4 .   ? 3.149   -0.085 25.117  1.00 28.12 ? 323 HOH L O   1 
HETATM 4160 O O   . HOH F 4 .   ? -22.929 32.793 25.365  1.00 17.46 ? 324 HOH L O   1 
HETATM 4161 O O   . HOH F 4 .   ? 11.110  -0.404 10.286  1.00 22.34 ? 325 HOH L O   1 
HETATM 4162 O O   . HOH F 4 .   ? 19.336  18.336 10.800  1.00 19.94 ? 326 HOH L O   1 
HETATM 4163 O O   . HOH F 4 .   ? -4.191  21.733 18.475  1.00 21.60 ? 327 HOH L O   1 
HETATM 4164 O O   . HOH F 4 .   ? 13.957  13.634 -9.817  1.00 18.80 ? 328 HOH L O   1 
HETATM 4165 O O   . HOH F 4 .   ? -32.680 21.401 30.120  1.00 30.27 ? 329 HOH L O   1 
HETATM 4166 O O   . HOH F 4 .   ? 11.685  12.151 -13.435 1.00 26.75 ? 330 HOH L O   1 
HETATM 4167 O O   . HOH F 4 .   ? -19.875 27.603 15.041  1.00 16.90 ? 331 HOH L O   1 
HETATM 4168 O O   . HOH F 4 .   ? -23.181 21.416 12.432  1.00 21.70 ? 332 HOH L O   1 
HETATM 4169 O O   . HOH F 4 .   ? -18.146 21.151 13.328  1.00 27.24 ? 333 HOH L O   1 
HETATM 4170 O O   . HOH F 4 .   ? -4.418  11.440 14.758  1.00 26.38 ? 334 HOH L O   1 
HETATM 4171 O O   . HOH F 4 .   ? 1.640   13.038 26.656  1.00 21.49 ? 335 HOH L O   1 
HETATM 4172 O O   . HOH F 4 .   ? 9.658   23.873 -12.241 1.00 23.78 ? 336 HOH L O   1 
HETATM 4173 O O   . HOH F 4 .   ? -1.413  3.575  13.089  1.00 22.30 ? 337 HOH L O   1 
HETATM 4174 O O   . HOH F 4 .   ? 16.665  2.900  13.093  1.00 19.47 ? 338 HOH L O   1 
HETATM 4175 O O   . HOH F 4 .   ? 3.129   18.355 3.519   1.00 16.70 ? 339 HOH L O   1 
HETATM 4176 O O   . HOH F 4 .   ? 8.605   17.377 -11.922 1.00 23.47 ? 340 HOH L O   1 
HETATM 4177 O O   . HOH F 4 .   ? 9.384   0.470  25.608  1.00 18.85 ? 341 HOH L O   1 
HETATM 4178 O O   . HOH F 4 .   ? 6.447   -0.808 17.543  1.00 17.17 ? 342 HOH L O   1 
HETATM 4179 O O   . HOH F 4 .   ? -23.752 18.431 13.366  1.00 27.41 ? 343 HOH L O   1 
HETATM 4180 O O   . HOH F 4 .   ? 6.650   -0.599 25.748  1.00 14.11 ? 344 HOH L O   1 
HETATM 4181 O O   . HOH F 4 .   ? 13.281  6.969  -7.330  1.00 21.64 ? 345 HOH L O   1 
HETATM 4182 O O   . HOH F 4 .   ? -12.856 5.152  29.258  1.00 23.53 ? 346 HOH L O   1 
HETATM 4183 O O   . HOH F 4 .   ? 18.081  3.059  0.716   1.00 25.85 ? 347 HOH L O   1 
HETATM 4184 O O   . HOH F 4 .   ? -22.467 28.586 25.129  1.00 18.45 ? 348 HOH L O   1 
HETATM 4185 O O   . HOH F 4 .   ? -5.878  16.516 30.584  1.00 22.12 ? 349 HOH L O   1 
HETATM 4186 O O   . HOH F 4 .   ? 19.851  11.092 21.191  1.00 33.02 ? 350 HOH L O   1 
HETATM 4187 O O   . HOH F 4 .   ? 21.233  12.971 -2.282  1.00 13.69 ? 351 HOH L O   1 
HETATM 4188 O O   . HOH F 4 .   ? 16.036  4.316  -6.206  1.00 19.87 ? 352 HOH L O   1 
HETATM 4189 O O   . HOH F 4 .   ? 2.995   13.938 18.313  1.00 17.96 ? 353 HOH L O   1 
HETATM 4190 O O   . HOH F 4 .   ? -5.057  18.137 25.961  1.00 14.87 ? 354 HOH L O   1 
HETATM 4191 O O   . HOH F 4 .   ? 11.242  20.538 14.620  1.00 16.49 ? 355 HOH L O   1 
HETATM 4192 O O   . HOH F 4 .   ? 16.558  -0.257 13.357  1.00 30.94 ? 356 HOH L O   1 
HETATM 4193 O O   . HOH F 4 .   ? 14.061  6.495  3.202   1.00 13.83 ? 357 HOH L O   1 
HETATM 4194 O O   . HOH F 4 .   ? 13.288  -0.696 24.038  1.00 24.81 ? 358 HOH L O   1 
HETATM 4195 O O   . HOH F 4 .   ? 5.397   8.358  6.878   1.00 12.04 ? 359 HOH L O   1 
HETATM 4196 O O   . HOH F 4 .   ? 7.523   -1.033 13.514  1.00 23.46 ? 360 HOH L O   1 
HETATM 4197 O O   . HOH F 4 .   ? -19.143 5.352  20.862  1.00 30.00 ? 361 HOH L O   1 
HETATM 4198 O O   . HOH F 4 .   ? 25.601  7.582  4.097   1.00 28.47 ? 362 HOH L O   1 
HETATM 4199 O O   . HOH F 4 .   ? 14.296  13.783 18.018  1.00 19.31 ? 363 HOH L O   1 
HETATM 4200 O O   . HOH F 4 .   ? -3.265  22.482 22.954  1.00 20.37 ? 364 HOH L O   1 
HETATM 4201 O O   . HOH F 4 .   ? -0.383  3.177  15.816  1.00 21.42 ? 365 HOH L O   1 
HETATM 4202 O O   . HOH F 4 .   ? -5.523  2.846  23.191  1.00 19.20 ? 366 HOH L O   1 
HETATM 4203 O O   . HOH F 4 .   ? 1.712   16.850 0.428   1.00 20.04 ? 367 HOH L O   1 
HETATM 4204 O O   . HOH F 4 .   ? -15.375 24.838 18.791  1.00 19.71 ? 368 HOH L O   1 
HETATM 4205 O O   . HOH F 4 .   ? -5.111  9.173  18.420  1.00 21.86 ? 369 HOH L O   1 
HETATM 4206 O O   . HOH F 4 .   ? 5.715   21.170 -2.336  1.00 12.00 ? 370 HOH L O   1 
HETATM 4207 O O   . HOH F 4 .   ? 14.274  2.186  7.537   1.00 22.55 ? 371 HOH L O   1 
HETATM 4208 O O   . HOH F 4 .   ? 7.411   3.302  27.432  1.00 21.48 ? 372 HOH L O   1 
HETATM 4209 O O   . HOH F 4 .   ? -0.891  16.325 19.908  1.00 21.17 ? 373 HOH L O   1 
HETATM 4210 O O   . HOH F 4 .   ? -29.057 30.322 12.495  1.00 23.42 ? 374 HOH L O   1 
HETATM 4211 O O   . HOH F 4 .   ? 2.906   5.037  2.028   1.00 24.19 ? 375 HOH L O   1 
HETATM 4212 O O   . HOH F 4 .   ? 12.792  12.818 -7.346  1.00 17.69 ? 376 HOH L O   1 
HETATM 4213 O O   . HOH F 4 .   ? 9.875   0.631  -5.691  1.00 24.89 ? 377 HOH L O   1 
HETATM 4214 O O   . HOH F 4 .   ? 7.859   16.996 -8.908  1.00 17.95 ? 378 HOH L O   1 
HETATM 4215 O O   . HOH F 4 .   ? -2.375  -1.468 22.921  1.00 28.26 ? 379 HOH L O   1 
HETATM 4216 O O   . HOH F 4 .   ? -25.216 35.850 30.427  1.00 30.24 ? 380 HOH L O   1 
HETATM 4217 O O   . HOH F 4 .   ? -6.938  16.516 27.090  1.00 13.81 ? 381 HOH L O   1 
HETATM 4218 O O   . HOH F 4 .   ? 12.865  11.062 -5.294  1.00 16.97 ? 382 HOH L O   1 
HETATM 4219 O O   . HOH F 4 .   ? -2.644  4.863  29.694  1.00 24.22 ? 383 HOH L O   1 
HETATM 4220 O O   . HOH F 4 .   ? -0.183  19.658 28.086  1.00 25.04 ? 384 HOH L O   1 
HETATM 4221 O O   . HOH F 4 .   ? -3.526  5.948  8.033   1.00 26.58 ? 385 HOH L O   1 
HETATM 4222 O O   . HOH F 4 .   ? -4.255  1.189  19.043  1.00 30.32 ? 386 HOH L O   1 
HETATM 4223 O O   . HOH F 4 .   ? 2.176   8.949  -4.238  1.00 21.73 ? 387 HOH L O   1 
HETATM 4224 O O   . HOH F 4 .   ? 15.317  23.626 12.042  1.00 24.48 ? 388 HOH L O   1 
HETATM 4225 O O   . HOH F 4 .   ? -23.745 19.007 30.272  1.00 19.95 ? 389 HOH L O   1 
HETATM 4226 O O   . HOH F 4 .   ? 0.783   17.315 8.599   1.00 23.48 ? 390 HOH L O   1 
HETATM 4227 O O   . HOH F 4 .   ? 3.686   23.051 14.725  1.00 28.26 ? 391 HOH L O   1 
HETATM 4228 O O   . HOH F 4 .   ? -0.689  19.829 25.443  1.00 26.64 ? 392 HOH L O   1 
HETATM 4229 O O   . HOH F 4 .   ? 0.706   8.152  28.739  1.00 27.90 ? 393 HOH L O   1 
HETATM 4230 O O   . HOH F 4 .   ? -19.964 12.129 29.681  1.00 26.42 ? 394 HOH L O   1 
HETATM 4231 O O   . HOH F 4 .   ? 5.913   1.246  14.106  1.00 18.92 ? 395 HOH L O   1 
HETATM 4232 O O   . HOH F 4 .   ? 8.792   13.714 -14.236 1.00 35.17 ? 396 HOH L O   1 
HETATM 4233 O O   . HOH F 4 .   ? -6.198  5.433  17.199  1.00 23.11 ? 397 HOH L O   1 
HETATM 4234 O O   . HOH F 4 .   ? 4.169   18.970 -1.802  1.00 12.68 ? 398 HOH L O   1 
HETATM 4235 O O   . HOH F 4 .   ? -9.203  3.859  17.229  1.00 22.24 ? 399 HOH L O   1 
HETATM 4236 O O   . HOH F 4 .   ? 20.320  7.031  -4.513  1.00 23.55 ? 400 HOH L O   1 
HETATM 4237 O O   . HOH F 4 .   ? -9.372  12.852 33.359  1.00 31.95 ? 401 HOH L O   1 
HETATM 4238 O O   . HOH F 4 .   ? -3.610  6.707  10.970  1.00 24.63 ? 402 HOH L O   1 
HETATM 4239 O O   . HOH F 4 .   ? -31.921 36.801 15.254  1.00 24.15 ? 403 HOH L O   1 
HETATM 4240 O O   . HOH F 4 .   ? 19.374  18.801 13.741  1.00 28.82 ? 404 HOH L O   1 
HETATM 4241 O O   . HOH F 4 .   ? -27.903 15.707 29.174  1.00 26.92 ? 405 HOH L O   1 
HETATM 4242 O O   . HOH F 4 .   ? 8.522   -2.009 19.391  1.00 18.81 ? 406 HOH L O   1 
HETATM 4243 O O   . HOH F 4 .   ? 23.281  17.902 7.396   1.00 26.47 ? 407 HOH L O   1 
HETATM 4244 O O   . HOH F 4 .   ? -2.597  11.362 6.320   1.00 24.50 ? 408 HOH L O   1 
HETATM 4245 O O   . HOH F 4 .   ? -3.499  12.106 17.024  1.00 22.08 ? 409 HOH L O   1 
HETATM 4246 O O   . HOH F 4 .   ? -35.303 29.469 10.038  1.00 38.61 ? 410 HOH L O   1 
HETATM 4247 O O   . HOH F 4 .   ? -26.922 33.453 31.281  1.00 34.23 ? 411 HOH L O   1 
HETATM 4248 O O   . HOH F 4 .   ? -4.514  4.691  19.335  1.00 17.13 ? 412 HOH L O   1 
HETATM 4249 O O   . HOH F 4 .   ? -22.138 36.813 19.652  1.00 19.86 ? 413 HOH L O   1 
HETATM 4250 O O   . HOH F 4 .   ? -7.253  11.824 32.389  1.00 30.13 ? 414 HOH L O   1 
HETATM 4251 O O   . HOH F 4 .   ? 20.061  7.237  19.184  1.00 25.57 ? 415 HOH L O   1 
HETATM 4252 O O   . HOH F 4 .   ? -10.269 15.001 16.457  1.00 28.09 ? 416 HOH L O   1 
HETATM 4253 O O   . HOH F 4 .   ? -16.923 24.730 9.602   1.00 33.78 ? 417 HOH L O   1 
HETATM 4254 O O   . HOH F 4 .   ? 18.903  6.716  20.825  1.00 29.01 ? 418 HOH L O   1 
HETATM 4255 O O   . HOH F 4 .   ? -20.252 27.760 12.380  1.00 25.69 ? 419 HOH L O   1 
HETATM 4256 O O   . HOH F 4 .   ? -4.756  9.051  10.840  1.00 30.68 ? 420 HOH L O   1 
HETATM 4257 O O   . HOH F 4 .   ? -5.644  18.264 32.077  1.00 23.47 ? 421 HOH L O   1 
HETATM 4258 O O   . HOH F 4 .   ? 18.248  15.147 18.891  1.00 39.23 ? 422 HOH L O   1 
HETATM 4259 O O   . HOH F 4 .   ? 0.567   14.895 10.530  1.00 24.82 ? 423 HOH L O   1 
HETATM 4260 O O   . HOH F 4 .   ? 0.486   16.977 14.950  1.00 29.36 ? 424 HOH L O   1 
HETATM 4261 O O   . HOH F 4 .   ? -5.280  22.869 16.049  1.00 30.29 ? 425 HOH L O   1 
HETATM 4262 O O   . HOH F 4 .   ? -2.365  23.818 19.288  1.00 30.04 ? 426 HOH L O   1 
HETATM 4263 O O   . HOH F 4 .   ? -33.612 38.450 16.756  1.00 28.80 ? 427 HOH L O   1 
HETATM 4264 O O   . HOH F 4 .   ? 2.980   16.515 16.942  1.00 19.41 ? 428 HOH L O   1 
HETATM 4265 O O   . HOH F 4 .   ? 0.177   18.152 2.790   1.00 19.55 ? 429 HOH L O   1 
HETATM 4266 O O   . HOH F 4 .   ? 10.583  -1.675 7.861   1.00 29.33 ? 430 HOH L O   1 
HETATM 4267 O O   . HOH F 4 .   ? 11.053  -0.182 27.302  1.00 25.58 ? 431 HOH L O   1 
HETATM 4268 O O   . HOH F 4 .   ? 22.906  11.078 -1.410  1.00 20.59 ? 432 HOH L O   1 
HETATM 4269 O O   . HOH F 4 .   ? 6.636   -3.314 20.882  1.00 17.41 ? 433 HOH L O   1 
HETATM 4270 O O   . HOH F 4 .   ? 6.101   1.077  27.834  1.00 20.67 ? 434 HOH L O   1 
HETATM 4271 O O   . HOH F 4 .   ? -0.645  23.367 22.412  1.00 28.76 ? 435 HOH L O   1 
HETATM 4272 O O   . HOH F 4 .   ? 4.140   21.795 -6.613  1.00 21.60 ? 436 HOH L O   1 
HETATM 4273 O O   . HOH F 4 .   ? 2.392   18.525 -3.928  1.00 23.28 ? 437 HOH L O   1 
HETATM 4274 O O   . HOH F 4 .   ? -0.523  16.387 12.763  1.00 23.32 ? 438 HOH L O   1 
# 
