data_9DQ2
# 
_entry.id   9DQ2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQ2         pdb_00009dq2 10.2210/pdb9dq2/pdb 
WWPDB D_1000288597 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQ2 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wchang6@ncsu.edu 
_pdbx_contact_author.name_first         Wei-chen 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2341-9846 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, Y.-C.' 1 ? 
'Chang, W.-C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            147 
_citation.language                  ? 
_citation.page_first                6162 
_citation.page_last                 6170 
_citation.title                     
;Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c17741 
_citation.pdbx_database_id_PubMed   39901767 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, Y.C.'   1  ? 
primary 'Li, X.'        2  ? 
primary 'Cha, L.'       3  ? 
primary 'Paris, J.C.'   4  ? 
primary 'Michael, C.'   5  ? 
primary 'Ushimaru, R.'  6  ? 
primary 'Ogasawara, Y.' 7  ? 
primary 'Abe, I.'       8  ? 
primary 'Guo, Y.'       9  ? 
primary 'Chang, W.C.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'BsmA domain containing protein' 26498.471 2   ? ? ? ? 
2 non-polymer syn 6-nitro-L-norleucine             176.170   2   ? ? ? ? 
3 non-polymer syn 'oxovanadium(2+)'                66.941    2   ? ? ? ? 
4 non-polymer syn 'SUCCINIC ACID'                  118.088   2   ? ? ? ? 
5 non-polymer syn GLYCEROL                         92.094    5   ? ? ? ? 
6 non-polymer syn 'BROMIDE ION'                    79.904    4   ? ? ? ? 
7 water       nat water                            18.015    659 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEAHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEAHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 6-nitro-L-norleucine 6HN 
3 'oxovanadium(2+)'    VVO 
4 'SUCCINIC ACID'      SIN 
5 GLYCEROL             GOL 
6 'BROMIDE ION'        BR  
7 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   PRO n 
1 3   LEU n 
1 4   GLY n 
1 5   THR n 
1 6   GLU n 
1 7   GLY n 
1 8   PHE n 
1 9   THR n 
1 10  VAL n 
1 11  ILE n 
1 12  ASP n 
1 13  LEU n 
1 14  PRO n 
1 15  GLU n 
1 16  VAL n 
1 17  ALA n 
1 18  PRO n 
1 19  ASP n 
1 20  ILE n 
1 21  LEU n 
1 22  PRO n 
1 23  SER n 
1 24  TYR n 
1 25  ASP n 
1 26  ARG n 
1 27  CYS n 
1 28  PRO n 
1 29  VAL n 
1 30  ASP n 
1 31  ASP n 
1 32  TYR n 
1 33  MET n 
1 34  GLY n 
1 35  ASN n 
1 36  GLY n 
1 37  THR n 
1 38  ARG n 
1 39  PHE n 
1 40  LYS n 
1 41  ARG n 
1 42  PHE n 
1 43  SER n 
1 44  GLN n 
1 45  TYR n 
1 46  LYS n 
1 47  LEU n 
1 48  THR n 
1 49  PRO n 
1 50  ALA n 
1 51  GLU n 
1 52  ASP n 
1 53  ASP n 
1 54  THR n 
1 55  TRP n 
1 56  SER n 
1 57  PHE n 
1 58  LYS n 
1 59  ARG n 
1 60  LEU n 
1 61  PRO n 
1 62  HIS n 
1 63  ARG n 
1 64  ASP n 
1 65  TYR n 
1 66  THR n 
1 67  THR n 
1 68  TYR n 
1 69  LYS n 
1 70  LYS n 
1 71  PHE n 
1 72  ASN n 
1 73  PRO n 
1 74  VAL n 
1 75  GLY n 
1 76  GLY n 
1 77  GLY n 
1 78  ILE n 
1 79  ARG n 
1 80  ARG n 
1 81  VAL n 
1 82  TYR n 
1 83  GLU n 
1 84  PRO n 
1 85  ILE n 
1 86  GLU n 
1 87  VAL n 
1 88  ASP n 
1 89  PHE n 
1 90  THR n 
1 91  PRO n 
1 92  LEU n 
1 93  ILE n 
1 94  SER n 
1 95  GLU n 
1 96  GLY n 
1 97  ILE n 
1 98  ARG n 
1 99  GLU n 
1 100 LEU n 
1 101 GLY n 
1 102 LEU n 
1 103 ASP n 
1 104 ARG n 
1 105 SER n 
1 106 GLU n 
1 107 PRO n 
1 108 TRP n 
1 109 GLN n 
1 110 ILE n 
1 111 ASN n 
1 112 VAL n 
1 113 HIS n 
1 114 GLN n 
1 115 ASN n 
1 116 ARG n 
1 117 THR n 
1 118 ARG n 
1 119 ALA n 
1 120 ASP n 
1 121 GLY n 
1 122 GLY n 
1 123 ARG n 
1 124 PRO n 
1 125 GLY n 
1 126 PRO n 
1 127 LEU n 
1 128 THR n 
1 129 PRO n 
1 130 GLU n 
1 131 GLY n 
1 132 VAL n 
1 133 HIS n 
1 134 HIS n 
1 135 ASP n 
1 136 GLY n 
1 137 HIS n 
1 138 GLU n 
1 139 PHE n 
1 140 VAL n 
1 141 MET n 
1 142 ILE n 
1 143 ALA n 
1 144 ILE n 
1 145 LEU n 
1 146 ASN n 
1 147 LYS n 
1 148 VAL n 
1 149 ASN n 
1 150 VAL n 
1 151 ALA n 
1 152 GLY n 
1 153 GLY n 
1 154 THR n 
1 155 THR n 
1 156 ARG n 
1 157 LEU n 
1 158 TRP n 
1 159 LYS n 
1 160 PRO n 
1 161 GLY n 
1 162 ALA n 
1 163 ASP n 
1 164 ALA n 
1 165 PRO n 
1 166 PHE n 
1 167 TRP n 
1 168 SER n 
1 169 GLY n 
1 170 THR n 
1 171 LEU n 
1 172 GLU n 
1 173 ALA n 
1 174 GLY n 
1 175 GLN n 
1 176 ALA n 
1 177 VAL n 
1 178 LEU n 
1 179 LEU n 
1 180 ASP n 
1 181 ASP n 
1 182 ARG n 
1 183 GLY n 
1 184 LEU n 
1 185 ALA n 
1 186 HIS n 
1 187 ASP n 
1 188 VAL n 
1 189 THR n 
1 190 ASP n 
1 191 VAL n 
1 192 LEU n 
1 193 SER n 
1 194 ALA n 
1 195 ASP n 
1 196 GLY n 
1 197 GLY n 
1 198 PRO n 
1 199 GLY n 
1 200 HIS n 
1 201 ARG n 
1 202 ASP n 
1 203 ILE n 
1 204 VAL n 
1 205 ILE n 
1 206 ILE n 
1 207 ALA n 
1 208 PHE n 
1 209 SER n 
1 210 ARG n 
1 211 TRP n 
1 212 ALA n 
1 213 GLU n 
1 214 LYS n 
1 215 TRP n 
1 216 TYR n 
1 217 GLY n 
1 218 ASP n 
1 219 GLU n 
1 220 HIS n 
1 221 ASP n 
1 222 ALA n 
1 223 ALA n 
1 224 ALA n 
1 225 LEU n 
1 226 GLU n 
1 227 GLU n 
1 228 GLN n 
1 229 GLU n 
1 230 ALA n 
1 231 HIS n 
1 232 HIS n 
1 233 HIS n 
1 234 HIS n 
1 235 HIS n 
1 236 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   236 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ABE83_05625 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp. CFMR 7' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1649184 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
6HN 'L-peptide linking' n 6-nitro-L-norleucine ?                               'C6 H12 N2 O4'   176.170 
ALA 'L-peptide linking' y ALANINE              ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ?                               'C4 H7 N O4'     133.103 
BR  non-polymer         . 'BROMIDE ION'        ?                               'Br -1'          79.904  
CYS 'L-peptide linking' y CYSTEINE             ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE            ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL             'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE            ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ?                               'C3 H7 N O3'     105.093 
SIN non-polymer         . 'SUCCINIC ACID'      ?                               'C4 H6 O4'       118.088 
THR 'L-peptide linking' y THREONINE            ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ?                               'C5 H11 N O2'    117.146 
VVO non-polymer         . 'oxovanadium(2+)'    ?                               'O V 2'          66.941  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   PRO 2   2   2   PRO PRO A . n 
A 1 3   LEU 3   3   3   LEU LEU A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   THR 5   5   5   THR THR A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   GLY 7   7   7   GLY GLY A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   THR 9   9   9   THR THR A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  ILE 11  11  11  ILE ILE A . n 
A 1 12  ASP 12  12  12  ASP ASP A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  PRO 14  14  14  PRO PRO A . n 
A 1 15  GLU 15  15  15  GLU GLU A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ASP 19  19  19  ASP ASP A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ARG 26  26  26  ARG ARG A . n 
A 1 27  CYS 27  27  27  CYS CYS A . n 
A 1 28  PRO 28  28  28  PRO PRO A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  TYR 32  32  32  TYR TYR A . n 
A 1 33  MET 33  33  33  MET MET A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  GLY 36  36  36  GLY GLY A . n 
A 1 37  THR 37  37  37  THR THR A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  PHE 39  39  39  PHE PHE A . n 
A 1 40  LYS 40  40  40  LYS LYS A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  PHE 42  42  42  PHE PHE A . n 
A 1 43  SER 43  43  43  SER SER A . n 
A 1 44  GLN 44  44  44  GLN GLN A . n 
A 1 45  TYR 45  45  45  TYR TYR A . n 
A 1 46  LYS 46  46  46  LYS LYS A . n 
A 1 47  LEU 47  47  47  LEU LEU A . n 
A 1 48  THR 48  48  48  THR THR A . n 
A 1 49  PRO 49  49  49  PRO PRO A . n 
A 1 50  ALA 50  50  50  ALA ALA A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  TRP 55  55  55  TRP TRP A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  PHE 57  57  57  PHE PHE A . n 
A 1 58  LYS 58  58  58  LYS LYS A . n 
A 1 59  ARG 59  59  59  ARG ARG A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  PRO 61  61  61  PRO PRO A . n 
A 1 62  HIS 62  62  62  HIS HIS A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  ASP 64  64  64  ASP ASP A . n 
A 1 65  TYR 65  65  65  TYR TYR A . n 
A 1 66  THR 66  66  66  THR THR A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  TYR 68  68  68  TYR TYR A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  VAL 74  74  74  VAL VAL A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  GLY 77  77  77  GLY GLY A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  GLU 83  83  83  GLU GLU A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  GLU 86  86  86  GLU GLU A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  ASP 88  88  88  ASP ASP A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  THR 90  90  90  THR THR A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  GLU 99  99  99  GLU GLU A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 LEU 102 102 102 LEU LEU A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ARG 104 104 104 ARG ARG A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 GLU 106 106 106 GLU GLU A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 GLN 109 109 109 GLN GLN A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 ASN 111 111 111 ASN ASN A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 HIS 113 113 113 HIS HIS A . n 
A 1 114 GLN 114 114 114 GLN GLN A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 ARG 118 118 118 ARG ARG A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 ASP 120 120 120 ASP ASP A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLY 122 122 122 GLY GLY A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 PRO 126 126 126 PRO PRO A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 THR 128 128 128 THR THR A . n 
A 1 129 PRO 129 129 129 PRO PRO A . n 
A 1 130 GLU 130 130 130 GLU GLU A . n 
A 1 131 GLY 131 131 131 GLY GLY A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 HIS 133 133 133 HIS HIS A . n 
A 1 134 HIS 134 134 134 HIS HIS A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 VAL 140 140 140 VAL VAL A . n 
A 1 141 MET 141 141 141 MET MET A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ILE 144 144 144 ILE ILE A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 ASN 149 149 149 ASN ASN A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 THR 154 154 154 THR THR A . n 
A 1 155 THR 155 155 155 THR THR A . n 
A 1 156 ARG 156 156 156 ARG ARG A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 TRP 158 158 158 TRP TRP A . n 
A 1 159 LYS 159 159 159 LYS LYS A . n 
A 1 160 PRO 160 160 160 PRO PRO A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 ALA 162 162 162 ALA ALA A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 PHE 166 166 166 PHE PHE A . n 
A 1 167 TRP 167 167 167 TRP TRP A . n 
A 1 168 SER 168 168 168 SER SER A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 THR 170 170 170 THR THR A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 GLU 172 172 172 GLU GLU A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 GLN 175 175 175 GLN GLN A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 ASP 180 180 180 ASP ASP A . n 
A 1 181 ASP 181 181 181 ASP ASP A . n 
A 1 182 ARG 182 182 182 ARG ARG A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 ALA 185 185 185 ALA ALA A . n 
A 1 186 HIS 186 186 186 HIS HIS A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 VAL 188 188 188 VAL VAL A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ASP 190 190 190 ASP ASP A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 GLY 197 197 197 GLY GLY A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ARG 201 201 201 ARG ARG A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 ILE 203 203 203 ILE ILE A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ILE 205 205 205 ILE ILE A . n 
A 1 206 ILE 206 206 206 ILE ILE A . n 
A 1 207 ALA 207 207 207 ALA ALA A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 SER 209 209 209 SER SER A . n 
A 1 210 ARG 210 210 210 ARG ARG A . n 
A 1 211 TRP 211 211 211 TRP TRP A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 TRP 215 215 215 TRP TRP A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 GLY 217 217 217 GLY GLY A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 GLU 219 219 219 GLU GLU A . n 
A 1 220 HIS 220 220 220 HIS HIS A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 GLU 226 226 226 GLU GLU A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 GLN 228 228 ?   ?   ?   A . n 
A 1 229 GLU 229 229 ?   ?   ?   A . n 
A 1 230 ALA 230 230 ?   ?   ?   A . n 
A 1 231 HIS 231 231 ?   ?   ?   A . n 
A 1 232 HIS 232 232 ?   ?   ?   A . n 
A 1 233 HIS 233 233 ?   ?   ?   A . n 
A 1 234 HIS 234 234 ?   ?   ?   A . n 
A 1 235 HIS 235 235 ?   ?   ?   A . n 
A 1 236 HIS 236 236 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   PRO 2   2   2   PRO PRO B . n 
B 1 3   LEU 3   3   3   LEU LEU B . n 
B 1 4   GLY 4   4   4   GLY GLY B . n 
B 1 5   THR 5   5   5   THR THR B . n 
B 1 6   GLU 6   6   6   GLU GLU B . n 
B 1 7   GLY 7   7   7   GLY GLY B . n 
B 1 8   PHE 8   8   8   PHE PHE B . n 
B 1 9   THR 9   9   9   THR THR B . n 
B 1 10  VAL 10  10  10  VAL VAL B . n 
B 1 11  ILE 11  11  11  ILE ILE B . n 
B 1 12  ASP 12  12  12  ASP ASP B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  PRO 14  14  14  PRO PRO B . n 
B 1 15  GLU 15  15  15  GLU GLU B . n 
B 1 16  VAL 16  16  16  VAL VAL B . n 
B 1 17  ALA 17  17  17  ALA ALA B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  ASP 19  19  19  ASP ASP B . n 
B 1 20  ILE 20  20  20  ILE ILE B . n 
B 1 21  LEU 21  21  21  LEU LEU B . n 
B 1 22  PRO 22  22  22  PRO PRO B . n 
B 1 23  SER 23  23  23  SER SER B . n 
B 1 24  TYR 24  24  24  TYR TYR B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ARG 26  26  26  ARG ARG B . n 
B 1 27  CYS 27  27  27  CYS CYS B . n 
B 1 28  PRO 28  28  28  PRO PRO B . n 
B 1 29  VAL 29  29  29  VAL VAL B . n 
B 1 30  ASP 30  30  30  ASP ASP B . n 
B 1 31  ASP 31  31  31  ASP ASP B . n 
B 1 32  TYR 32  32  32  TYR TYR B . n 
B 1 33  MET 33  33  33  MET MET B . n 
B 1 34  GLY 34  34  34  GLY GLY B . n 
B 1 35  ASN 35  35  35  ASN ASN B . n 
B 1 36  GLY 36  36  36  GLY GLY B . n 
B 1 37  THR 37  37  37  THR THR B . n 
B 1 38  ARG 38  38  38  ARG ARG B . n 
B 1 39  PHE 39  39  39  PHE PHE B . n 
B 1 40  LYS 40  40  40  LYS LYS B . n 
B 1 41  ARG 41  41  41  ARG ARG B . n 
B 1 42  PHE 42  42  42  PHE PHE B . n 
B 1 43  SER 43  43  43  SER SER B . n 
B 1 44  GLN 44  44  44  GLN GLN B . n 
B 1 45  TYR 45  45  45  TYR TYR B . n 
B 1 46  LYS 46  46  46  LYS LYS B . n 
B 1 47  LEU 47  47  47  LEU LEU B . n 
B 1 48  THR 48  48  48  THR THR B . n 
B 1 49  PRO 49  49  49  PRO PRO B . n 
B 1 50  ALA 50  50  50  ALA ALA B . n 
B 1 51  GLU 51  51  51  GLU GLU B . n 
B 1 52  ASP 52  52  52  ASP ASP B . n 
B 1 53  ASP 53  53  53  ASP ASP B . n 
B 1 54  THR 54  54  54  THR THR B . n 
B 1 55  TRP 55  55  55  TRP TRP B . n 
B 1 56  SER 56  56  56  SER SER B . n 
B 1 57  PHE 57  57  57  PHE PHE B . n 
B 1 58  LYS 58  58  58  LYS LYS B . n 
B 1 59  ARG 59  59  59  ARG ARG B . n 
B 1 60  LEU 60  60  60  LEU LEU B . n 
B 1 61  PRO 61  61  61  PRO PRO B . n 
B 1 62  HIS 62  62  62  HIS HIS B . n 
B 1 63  ARG 63  63  63  ARG ARG B . n 
B 1 64  ASP 64  64  64  ASP ASP B . n 
B 1 65  TYR 65  65  65  TYR TYR B . n 
B 1 66  THR 66  66  66  THR THR B . n 
B 1 67  THR 67  67  67  THR THR B . n 
B 1 68  TYR 68  68  68  TYR TYR B . n 
B 1 69  LYS 69  69  69  LYS LYS B . n 
B 1 70  LYS 70  70  70  LYS LYS B . n 
B 1 71  PHE 71  71  71  PHE PHE B . n 
B 1 72  ASN 72  72  72  ASN ASN B . n 
B 1 73  PRO 73  73  73  PRO PRO B . n 
B 1 74  VAL 74  74  74  VAL VAL B . n 
B 1 75  GLY 75  75  75  GLY GLY B . n 
B 1 76  GLY 76  76  76  GLY GLY B . n 
B 1 77  GLY 77  77  77  GLY GLY B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  ARG 79  79  79  ARG ARG B . n 
B 1 80  ARG 80  80  80  ARG ARG B . n 
B 1 81  VAL 81  81  81  VAL VAL B . n 
B 1 82  TYR 82  82  82  TYR TYR B . n 
B 1 83  GLU 83  83  83  GLU GLU B . n 
B 1 84  PRO 84  84  84  PRO PRO B . n 
B 1 85  ILE 85  85  85  ILE ILE B . n 
B 1 86  GLU 86  86  86  GLU GLU B . n 
B 1 87  VAL 87  87  87  VAL VAL B . n 
B 1 88  ASP 88  88  88  ASP ASP B . n 
B 1 89  PHE 89  89  89  PHE PHE B . n 
B 1 90  THR 90  90  90  THR THR B . n 
B 1 91  PRO 91  91  91  PRO PRO B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ILE 93  93  93  ILE ILE B . n 
B 1 94  SER 94  94  94  SER SER B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  GLY 96  96  96  GLY GLY B . n 
B 1 97  ILE 97  97  97  ILE ILE B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  GLU 99  99  99  GLU GLU B . n 
B 1 100 LEU 100 100 100 LEU LEU B . n 
B 1 101 GLY 101 101 101 GLY GLY B . n 
B 1 102 LEU 102 102 102 LEU LEU B . n 
B 1 103 ASP 103 103 103 ASP ASP B . n 
B 1 104 ARG 104 104 104 ARG ARG B . n 
B 1 105 SER 105 105 105 SER SER B . n 
B 1 106 GLU 106 106 106 GLU GLU B . n 
B 1 107 PRO 107 107 107 PRO PRO B . n 
B 1 108 TRP 108 108 108 TRP TRP B . n 
B 1 109 GLN 109 109 109 GLN GLN B . n 
B 1 110 ILE 110 110 110 ILE ILE B . n 
B 1 111 ASN 111 111 111 ASN ASN B . n 
B 1 112 VAL 112 112 112 VAL VAL B . n 
B 1 113 HIS 113 113 113 HIS HIS B . n 
B 1 114 GLN 114 114 114 GLN GLN B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 THR 117 117 117 THR THR B . n 
B 1 118 ARG 118 118 118 ARG ARG B . n 
B 1 119 ALA 119 119 119 ALA ALA B . n 
B 1 120 ASP 120 120 120 ASP ASP B . n 
B 1 121 GLY 121 121 121 GLY GLY B . n 
B 1 122 GLY 122 122 122 GLY GLY B . n 
B 1 123 ARG 123 123 123 ARG ARG B . n 
B 1 124 PRO 124 124 124 PRO PRO B . n 
B 1 125 GLY 125 125 125 GLY GLY B . n 
B 1 126 PRO 126 126 126 PRO PRO B . n 
B 1 127 LEU 127 127 127 LEU LEU B . n 
B 1 128 THR 128 128 128 THR THR B . n 
B 1 129 PRO 129 129 129 PRO PRO B . n 
B 1 130 GLU 130 130 130 GLU GLU B . n 
B 1 131 GLY 131 131 131 GLY GLY B . n 
B 1 132 VAL 132 132 132 VAL VAL B . n 
B 1 133 HIS 133 133 133 HIS HIS B . n 
B 1 134 HIS 134 134 134 HIS HIS B . n 
B 1 135 ASP 135 135 135 ASP ASP B . n 
B 1 136 GLY 136 136 136 GLY GLY B . n 
B 1 137 HIS 137 137 137 HIS HIS B . n 
B 1 138 GLU 138 138 138 GLU GLU B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 VAL 140 140 140 VAL VAL B . n 
B 1 141 MET 141 141 141 MET MET B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 ALA 143 143 143 ALA ALA B . n 
B 1 144 ILE 144 144 144 ILE ILE B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 ASN 146 146 146 ASN ASN B . n 
B 1 147 LYS 147 147 147 LYS LYS B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 ASN 149 149 149 ASN ASN B . n 
B 1 150 VAL 150 150 150 VAL VAL B . n 
B 1 151 ALA 151 151 151 ALA ALA B . n 
B 1 152 GLY 152 152 152 GLY GLY B . n 
B 1 153 GLY 153 153 153 GLY GLY B . n 
B 1 154 THR 154 154 154 THR THR B . n 
B 1 155 THR 155 155 155 THR THR B . n 
B 1 156 ARG 156 156 156 ARG ARG B . n 
B 1 157 LEU 157 157 157 LEU LEU B . n 
B 1 158 TRP 158 158 158 TRP TRP B . n 
B 1 159 LYS 159 159 159 LYS LYS B . n 
B 1 160 PRO 160 160 160 PRO PRO B . n 
B 1 161 GLY 161 161 161 GLY GLY B . n 
B 1 162 ALA 162 162 162 ALA ALA B . n 
B 1 163 ASP 163 163 163 ASP ASP B . n 
B 1 164 ALA 164 164 164 ALA ALA B . n 
B 1 165 PRO 165 165 165 PRO PRO B . n 
B 1 166 PHE 166 166 166 PHE PHE B . n 
B 1 167 TRP 167 167 167 TRP TRP B . n 
B 1 168 SER 168 168 168 SER SER B . n 
B 1 169 GLY 169 169 169 GLY GLY B . n 
B 1 170 THR 170 170 170 THR THR B . n 
B 1 171 LEU 171 171 171 LEU LEU B . n 
B 1 172 GLU 172 172 172 GLU GLU B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 GLN 175 175 175 GLN GLN B . n 
B 1 176 ALA 176 176 176 ALA ALA B . n 
B 1 177 VAL 177 177 177 VAL VAL B . n 
B 1 178 LEU 178 178 178 LEU LEU B . n 
B 1 179 LEU 179 179 179 LEU LEU B . n 
B 1 180 ASP 180 180 180 ASP ASP B . n 
B 1 181 ASP 181 181 181 ASP ASP B . n 
B 1 182 ARG 182 182 182 ARG ARG B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 ALA 185 185 185 ALA ALA B . n 
B 1 186 HIS 186 186 186 HIS HIS B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 VAL 188 188 188 VAL VAL B . n 
B 1 189 THR 189 189 189 THR THR B . n 
B 1 190 ASP 190 190 190 ASP ASP B . n 
B 1 191 VAL 191 191 191 VAL VAL B . n 
B 1 192 LEU 192 192 192 LEU LEU B . n 
B 1 193 SER 193 193 193 SER SER B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 ASP 195 195 195 ASP ASP B . n 
B 1 196 GLY 196 196 196 GLY GLY B . n 
B 1 197 GLY 197 197 197 GLY GLY B . n 
B 1 198 PRO 198 198 198 PRO PRO B . n 
B 1 199 GLY 199 199 199 GLY GLY B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ARG 201 201 201 ARG ARG B . n 
B 1 202 ASP 202 202 202 ASP ASP B . n 
B 1 203 ILE 203 203 203 ILE ILE B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 ILE 205 205 205 ILE ILE B . n 
B 1 206 ILE 206 206 206 ILE ILE B . n 
B 1 207 ALA 207 207 207 ALA ALA B . n 
B 1 208 PHE 208 208 208 PHE PHE B . n 
B 1 209 SER 209 209 209 SER SER B . n 
B 1 210 ARG 210 210 210 ARG ARG B . n 
B 1 211 TRP 211 211 211 TRP TRP B . n 
B 1 212 ALA 212 212 212 ALA ALA B . n 
B 1 213 GLU 213 213 213 GLU GLU B . n 
B 1 214 LYS 214 214 214 LYS LYS B . n 
B 1 215 TRP 215 215 215 TRP TRP B . n 
B 1 216 TYR 216 216 216 TYR TYR B . n 
B 1 217 GLY 217 217 217 GLY GLY B . n 
B 1 218 ASP 218 218 218 ASP ASP B . n 
B 1 219 GLU 219 219 219 GLU GLU B . n 
B 1 220 HIS 220 220 220 HIS HIS B . n 
B 1 221 ASP 221 221 221 ASP ASP B . n 
B 1 222 ALA 222 222 222 ALA ALA B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 LEU 225 225 225 LEU LEU B . n 
B 1 226 GLU 226 226 226 GLU GLU B . n 
B 1 227 GLU 227 227 227 GLU GLU B . n 
B 1 228 GLN 228 228 ?   ?   ?   B . n 
B 1 229 GLU 229 229 ?   ?   ?   B . n 
B 1 230 ALA 230 230 ?   ?   ?   B . n 
B 1 231 HIS 231 231 ?   ?   ?   B . n 
B 1 232 HIS 232 232 ?   ?   ?   B . n 
B 1 233 HIS 233 233 ?   ?   ?   B . n 
B 1 234 HIS 234 234 ?   ?   ?   B . n 
B 1 235 HIS 235 235 ?   ?   ?   B . n 
B 1 236 HIS 236 236 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 6HN ? ? 6HN ? ? 'SUBJECT OF INVESTIGATION' ? 
2 SIN ? ? SIN ? ? 'SUBJECT OF INVESTIGATION' ? 
3 VVO ? ? VVO ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 6HN 1   301 301 6HN 6NK A . 
D 3 VVO 1   302 302 VVO VVO A . 
E 4 SIN 1   303 303 SIN SIN A . 
F 5 GOL 1   304 304 GOL GOL A . 
G 5 GOL 1   305 561 GOL GOL A . 
H 6 BR  1   306 2   BR  BR  A . 
I 6 BR  1   307 3   BR  BR  A . 
J 6 BR  1   308 4   BR  BR  A . 
K 2 6HN 1   301 301 6HN 6NK B . 
L 3 VVO 1   302 302 VVO VVO B . 
M 4 SIN 1   303 303 SIN SIN B . 
N 5 GOL 1   304 304 GOL GOL B . 
O 5 GOL 1   305 305 GOL GOL B . 
P 5 GOL 1   306 306 GOL GOL B . 
Q 6 BR  1   307 1   BR  BR  B . 
R 7 HOH 1   401 7   HOH HOH A . 
R 7 HOH 2   402 485 HOH HOH A . 
R 7 HOH 3   403 353 HOH HOH A . 
R 7 HOH 4   404 490 HOH HOH A . 
R 7 HOH 5   405 631 HOH HOH A . 
R 7 HOH 6   406 282 HOH HOH A . 
R 7 HOH 7   407 319 HOH HOH A . 
R 7 HOH 8   408 348 HOH HOH A . 
R 7 HOH 9   409 90  HOH HOH A . 
R 7 HOH 10  410 283 HOH HOH A . 
R 7 HOH 11  411 594 HOH HOH A . 
R 7 HOH 12  412 466 HOH HOH A . 
R 7 HOH 13  413 604 HOH HOH A . 
R 7 HOH 14  414 194 HOH HOH A . 
R 7 HOH 15  415 809 HOH HOH A . 
R 7 HOH 16  416 300 HOH HOH A . 
R 7 HOH 17  417 20  HOH HOH A . 
R 7 HOH 18  418 273 HOH HOH A . 
R 7 HOH 19  419 552 HOH HOH A . 
R 7 HOH 20  420 336 HOH HOH A . 
R 7 HOH 21  421 567 HOH HOH A . 
R 7 HOH 22  422 365 HOH HOH A . 
R 7 HOH 23  423 94  HOH HOH A . 
R 7 HOH 24  424 405 HOH HOH A . 
R 7 HOH 25  425 278 HOH HOH A . 
R 7 HOH 26  426 473 HOH HOH A . 
R 7 HOH 27  427 225 HOH HOH A . 
R 7 HOH 28  428 493 HOH HOH A . 
R 7 HOH 29  429 88  HOH HOH A . 
R 7 HOH 30  430 59  HOH HOH A . 
R 7 HOH 31  431 232 HOH HOH A . 
R 7 HOH 32  432 111 HOH HOH A . 
R 7 HOH 33  433 171 HOH HOH A . 
R 7 HOH 34  434 198 HOH HOH A . 
R 7 HOH 35  435 328 HOH HOH A . 
R 7 HOH 36  436 17  HOH HOH A . 
R 7 HOH 37  437 109 HOH HOH A . 
R 7 HOH 38  438 135 HOH HOH A . 
R 7 HOH 39  439 107 HOH HOH A . 
R 7 HOH 40  440 116 HOH HOH A . 
R 7 HOH 41  441 508 HOH HOH A . 
R 7 HOH 42  442 8   HOH HOH A . 
R 7 HOH 43  443 74  HOH HOH A . 
R 7 HOH 44  444 202 HOH HOH A . 
R 7 HOH 45  445 54  HOH HOH A . 
R 7 HOH 46  446 399 HOH HOH A . 
R 7 HOH 47  447 35  HOH HOH A . 
R 7 HOH 48  448 10  HOH HOH A . 
R 7 HOH 49  449 33  HOH HOH A . 
R 7 HOH 50  450 53  HOH HOH A . 
R 7 HOH 51  451 596 HOH HOH A . 
R 7 HOH 52  452 638 HOH HOH A . 
R 7 HOH 53  453 314 HOH HOH A . 
R 7 HOH 54  454 15  HOH HOH A . 
R 7 HOH 55  455 441 HOH HOH A . 
R 7 HOH 56  456 701 HOH HOH A . 
R 7 HOH 57  457 6   HOH HOH A . 
R 7 HOH 58  458 179 HOH HOH A . 
R 7 HOH 59  459 479 HOH HOH A . 
R 7 HOH 60  460 29  HOH HOH A . 
R 7 HOH 61  461 559 HOH HOH A . 
R 7 HOH 62  462 395 HOH HOH A . 
R 7 HOH 63  463 245 HOH HOH A . 
R 7 HOH 64  464 108 HOH HOH A . 
R 7 HOH 65  465 643 HOH HOH A . 
R 7 HOH 66  466 12  HOH HOH A . 
R 7 HOH 67  467 369 HOH HOH A . 
R 7 HOH 68  468 558 HOH HOH A . 
R 7 HOH 69  469 312 HOH HOH A . 
R 7 HOH 70  470 140 HOH HOH A . 
R 7 HOH 71  471 370 HOH HOH A . 
R 7 HOH 72  472 97  HOH HOH A . 
R 7 HOH 73  473 21  HOH HOH A . 
R 7 HOH 74  474 42  HOH HOH A . 
R 7 HOH 75  475 45  HOH HOH A . 
R 7 HOH 76  476 380 HOH HOH A . 
R 7 HOH 77  477 68  HOH HOH A . 
R 7 HOH 78  478 496 HOH HOH A . 
R 7 HOH 79  479 47  HOH HOH A . 
R 7 HOH 80  480 150 HOH HOH A . 
R 7 HOH 81  481 408 HOH HOH A . 
R 7 HOH 82  482 196 HOH HOH A . 
R 7 HOH 83  483 102 HOH HOH A . 
R 7 HOH 84  484 280 HOH HOH A . 
R 7 HOH 85  485 2   HOH HOH A . 
R 7 HOH 86  486 148 HOH HOH A . 
R 7 HOH 87  487 301 HOH HOH A . 
R 7 HOH 88  488 70  HOH HOH A . 
R 7 HOH 89  489 432 HOH HOH A . 
R 7 HOH 90  490 51  HOH HOH A . 
R 7 HOH 91  491 5   HOH HOH A . 
R 7 HOH 92  492 154 HOH HOH A . 
R 7 HOH 93  493 294 HOH HOH A . 
R 7 HOH 94  494 208 HOH HOH A . 
R 7 HOH 95  495 125 HOH HOH A . 
R 7 HOH 96  496 263 HOH HOH A . 
R 7 HOH 97  497 381 HOH HOH A . 
R 7 HOH 98  498 870 HOH HOH A . 
R 7 HOH 99  499 43  HOH HOH A . 
R 7 HOH 100 500 239 HOH HOH A . 
R 7 HOH 101 501 177 HOH HOH A . 
R 7 HOH 102 502 256 HOH HOH A . 
R 7 HOH 103 503 110 HOH HOH A . 
R 7 HOH 104 504 216 HOH HOH A . 
R 7 HOH 105 505 19  HOH HOH A . 
R 7 HOH 106 506 40  HOH HOH A . 
R 7 HOH 107 507 254 HOH HOH A . 
R 7 HOH 108 508 253 HOH HOH A . 
R 7 HOH 109 509 96  HOH HOH A . 
R 7 HOH 110 510 248 HOH HOH A . 
R 7 HOH 111 511 265 HOH HOH A . 
R 7 HOH 112 512 461 HOH HOH A . 
R 7 HOH 113 513 288 HOH HOH A . 
R 7 HOH 114 514 136 HOH HOH A . 
R 7 HOH 115 515 145 HOH HOH A . 
R 7 HOH 116 516 893 HOH HOH A . 
R 7 HOH 117 517 298 HOH HOH A . 
R 7 HOH 118 518 271 HOH HOH A . 
R 7 HOH 119 519 429 HOH HOH A . 
R 7 HOH 120 520 38  HOH HOH A . 
R 7 HOH 121 521 81  HOH HOH A . 
R 7 HOH 122 522 433 HOH HOH A . 
R 7 HOH 123 523 56  HOH HOH A . 
R 7 HOH 124 524 89  HOH HOH A . 
R 7 HOH 125 525 262 HOH HOH A . 
R 7 HOH 126 526 26  HOH HOH A . 
R 7 HOH 127 527 83  HOH HOH A . 
R 7 HOH 128 528 66  HOH HOH A . 
R 7 HOH 129 529 302 HOH HOH A . 
R 7 HOH 130 530 174 HOH HOH A . 
R 7 HOH 131 531 61  HOH HOH A . 
R 7 HOH 132 532 453 HOH HOH A . 
R 7 HOH 133 533 268 HOH HOH A . 
R 7 HOH 134 534 589 HOH HOH A . 
R 7 HOH 135 535 660 HOH HOH A . 
R 7 HOH 136 536 322 HOH HOH A . 
R 7 HOH 137 537 341 HOH HOH A . 
R 7 HOH 138 538 231 HOH HOH A . 
R 7 HOH 139 539 219 HOH HOH A . 
R 7 HOH 140 540 398 HOH HOH A . 
R 7 HOH 141 541 175 HOH HOH A . 
R 7 HOH 142 542 106 HOH HOH A . 
R 7 HOH 143 543 215 HOH HOH A . 
R 7 HOH 144 544 228 HOH HOH A . 
R 7 HOH 145 545 65  HOH HOH A . 
R 7 HOH 146 546 31  HOH HOH A . 
R 7 HOH 147 547 10  HOH HOH A . 
R 7 HOH 148 548 176 HOH HOH A . 
R 7 HOH 149 549 189 HOH HOH A . 
R 7 HOH 150 550 537 HOH HOH A . 
R 7 HOH 151 551 44  HOH HOH A . 
R 7 HOH 152 552 201 HOH HOH A . 
R 7 HOH 153 553 358 HOH HOH A . 
R 7 HOH 154 554 147 HOH HOH A . 
R 7 HOH 155 555 105 HOH HOH A . 
R 7 HOH 156 556 165 HOH HOH A . 
R 7 HOH 157 557 421 HOH HOH A . 
R 7 HOH 158 558 200 HOH HOH A . 
R 7 HOH 159 559 354 HOH HOH A . 
R 7 HOH 160 560 418 HOH HOH A . 
R 7 HOH 161 561 234 HOH HOH A . 
R 7 HOH 162 562 172 HOH HOH A . 
R 7 HOH 163 563 205 HOH HOH A . 
R 7 HOH 164 564 261 HOH HOH A . 
R 7 HOH 165 565 210 HOH HOH A . 
R 7 HOH 166 566 63  HOH HOH A . 
R 7 HOH 167 567 287 HOH HOH A . 
R 7 HOH 168 568 749 HOH HOH A . 
R 7 HOH 169 569 155 HOH HOH A . 
R 7 HOH 170 570 339 HOH HOH A . 
R 7 HOH 171 571 95  HOH HOH A . 
R 7 HOH 172 572 362 HOH HOH A . 
R 7 HOH 173 573 741 HOH HOH A . 
R 7 HOH 174 574 55  HOH HOH A . 
R 7 HOH 175 575 11  HOH HOH A . 
R 7 HOH 176 576 233 HOH HOH A . 
R 7 HOH 177 577 371 HOH HOH A . 
R 7 HOH 178 578 656 HOH HOH A . 
R 7 HOH 179 579 531 HOH HOH A . 
R 7 HOH 180 580 652 HOH HOH A . 
R 7 HOH 181 581 115 HOH HOH A . 
R 7 HOH 182 582 374 HOH HOH A . 
R 7 HOH 183 583 229 HOH HOH A . 
R 7 HOH 184 584 137 HOH HOH A . 
R 7 HOH 185 585 130 HOH HOH A . 
R 7 HOH 186 586 238 HOH HOH A . 
R 7 HOH 187 587 424 HOH HOH A . 
R 7 HOH 188 588 161 HOH HOH A . 
R 7 HOH 189 589 127 HOH HOH A . 
R 7 HOH 190 590 260 HOH HOH A . 
R 7 HOH 191 591 126 HOH HOH A . 
R 7 HOH 192 592 685 HOH HOH A . 
R 7 HOH 193 593 146 HOH HOH A . 
R 7 HOH 194 594 335 HOH HOH A . 
R 7 HOH 195 595 257 HOH HOH A . 
R 7 HOH 196 596 209 HOH HOH A . 
R 7 HOH 197 597 442 HOH HOH A . 
R 7 HOH 198 598 448 HOH HOH A . 
R 7 HOH 199 599 892 HOH HOH A . 
R 7 HOH 200 600 363 HOH HOH A . 
R 7 HOH 201 601 77  HOH HOH A . 
R 7 HOH 202 602 533 HOH HOH A . 
R 7 HOH 203 603 677 HOH HOH A . 
R 7 HOH 204 604 297 HOH HOH A . 
R 7 HOH 205 605 73  HOH HOH A . 
R 7 HOH 206 606 483 HOH HOH A . 
R 7 HOH 207 607 517 HOH HOH A . 
R 7 HOH 208 608 553 HOH HOH A . 
R 7 HOH 209 609 156 HOH HOH A . 
R 7 HOH 210 610 305 HOH HOH A . 
R 7 HOH 211 611 134 HOH HOH A . 
R 7 HOH 212 612 599 HOH HOH A . 
R 7 HOH 213 613 571 HOH HOH A . 
R 7 HOH 214 614 583 HOH HOH A . 
R 7 HOH 215 615 364 HOH HOH A . 
R 7 HOH 216 616 675 HOH HOH A . 
R 7 HOH 217 617 566 HOH HOH A . 
R 7 HOH 218 618 489 HOH HOH A . 
R 7 HOH 219 619 667 HOH HOH A . 
R 7 HOH 220 620 555 HOH HOH A . 
R 7 HOH 221 621 585 HOH HOH A . 
R 7 HOH 222 622 623 HOH HOH A . 
R 7 HOH 223 623 428 HOH HOH A . 
R 7 HOH 224 624 449 HOH HOH A . 
R 7 HOH 225 625 437 HOH HOH A . 
R 7 HOH 226 626 624 HOH HOH A . 
R 7 HOH 227 627 387 HOH HOH A . 
R 7 HOH 228 628 747 HOH HOH A . 
R 7 HOH 229 629 235 HOH HOH A . 
R 7 HOH 230 630 290 HOH HOH A . 
R 7 HOH 231 631 581 HOH HOH A . 
R 7 HOH 232 632 129 HOH HOH A . 
R 7 HOH 233 633 885 HOH HOH A . 
R 7 HOH 234 634 159 HOH HOH A . 
R 7 HOH 235 635 356 HOH HOH A . 
R 7 HOH 236 636 808 HOH HOH A . 
R 7 HOH 237 637 394 HOH HOH A . 
R 7 HOH 238 638 524 HOH HOH A . 
R 7 HOH 239 639 247 HOH HOH A . 
R 7 HOH 240 640 367 HOH HOH A . 
R 7 HOH 241 641 133 HOH HOH A . 
R 7 HOH 242 642 434 HOH HOH A . 
R 7 HOH 243 643 2   HOH HOH A . 
R 7 HOH 244 644 532 HOH HOH A . 
R 7 HOH 245 645 536 HOH HOH A . 
R 7 HOH 246 646 407 HOH HOH A . 
R 7 HOH 247 647 718 HOH HOH A . 
R 7 HOH 248 648 590 HOH HOH A . 
R 7 HOH 249 649 327 HOH HOH A . 
R 7 HOH 250 650 593 HOH HOH A . 
R 7 HOH 251 651 246 HOH HOH A . 
R 7 HOH 252 652 563 HOH HOH A . 
R 7 HOH 253 653 607 HOH HOH A . 
R 7 HOH 254 654 869 HOH HOH A . 
R 7 HOH 255 655 834 HOH HOH A . 
R 7 HOH 256 656 564 HOH HOH A . 
R 7 HOH 257 657 500 HOH HOH A . 
R 7 HOH 258 658 823 HOH HOH A . 
R 7 HOH 259 659 516 HOH HOH A . 
R 7 HOH 260 660 223 HOH HOH A . 
R 7 HOH 261 661 694 HOH HOH A . 
R 7 HOH 262 662 530 HOH HOH A . 
R 7 HOH 263 663 633 HOH HOH A . 
R 7 HOH 264 664 484 HOH HOH A . 
R 7 HOH 265 665 911 HOH HOH A . 
R 7 HOH 266 666 311 HOH HOH A . 
R 7 HOH 267 667 476 HOH HOH A . 
R 7 HOH 268 668 204 HOH HOH A . 
R 7 HOH 269 669 355 HOH HOH A . 
R 7 HOH 270 670 458 HOH HOH A . 
R 7 HOH 271 671 894 HOH HOH A . 
R 7 HOH 272 672 628 HOH HOH A . 
R 7 HOH 273 673 402 HOH HOH A . 
R 7 HOH 274 674 509 HOH HOH A . 
R 7 HOH 275 675 527 HOH HOH A . 
R 7 HOH 276 676 732 HOH HOH A . 
R 7 HOH 277 677 679 HOH HOH A . 
R 7 HOH 278 678 457 HOH HOH A . 
R 7 HOH 279 679 514 HOH HOH A . 
R 7 HOH 280 680 409 HOH HOH A . 
R 7 HOH 281 681 480 HOH HOH A . 
R 7 HOH 282 682 373 HOH HOH A . 
R 7 HOH 283 683 486 HOH HOH A . 
R 7 HOH 284 684 326 HOH HOH A . 
R 7 HOH 285 685 543 HOH HOH A . 
R 7 HOH 286 686 414 HOH HOH A . 
R 7 HOH 287 687 325 HOH HOH A . 
R 7 HOH 288 688 481 HOH HOH A . 
R 7 HOH 289 689 451 HOH HOH A . 
R 7 HOH 290 690 100 HOH HOH A . 
R 7 HOH 291 691 907 HOH HOH A . 
R 7 HOH 292 692 391 HOH HOH A . 
R 7 HOH 293 693 316 HOH HOH A . 
R 7 HOH 294 694 9   HOH HOH A . 
R 7 HOH 295 695 503 HOH HOH A . 
R 7 HOH 296 696 313 HOH HOH A . 
R 7 HOH 297 697 270 HOH HOH A . 
R 7 HOH 298 698 467 HOH HOH A . 
R 7 HOH 299 699 670 HOH HOH A . 
R 7 HOH 300 700 592 HOH HOH A . 
R 7 HOH 301 701 5   HOH HOH A . 
R 7 HOH 302 702 406 HOH HOH A . 
R 7 HOH 303 703 276 HOH HOH A . 
R 7 HOH 304 704 845 HOH HOH A . 
R 7 HOH 305 705 605 HOH HOH A . 
R 7 HOH 306 706 618 HOH HOH A . 
R 7 HOH 307 707 862 HOH HOH A . 
R 7 HOH 308 708 504 HOH HOH A . 
R 7 HOH 309 709 658 HOH HOH A . 
R 7 HOH 310 710 388 HOH HOH A . 
R 7 HOH 311 711 279 HOH HOH A . 
R 7 HOH 312 712 573 HOH HOH A . 
R 7 HOH 313 713 745 HOH HOH A . 
R 7 HOH 314 714 544 HOH HOH A . 
R 7 HOH 315 715 217 HOH HOH A . 
R 7 HOH 316 716 698 HOH HOH A . 
R 7 HOH 317 717 578 HOH HOH A . 
R 7 HOH 318 718 347 HOH HOH A . 
R 7 HOH 319 719 518 HOH HOH A . 
R 7 HOH 320 720 411 HOH HOH A . 
R 7 HOH 321 721 471 HOH HOH A . 
R 7 HOH 322 722 456 HOH HOH A . 
R 7 HOH 323 723 603 HOH HOH A . 
R 7 HOH 324 724 574 HOH HOH A . 
R 7 HOH 325 725 540 HOH HOH A . 
R 7 HOH 326 726 610 HOH HOH A . 
R 7 HOH 327 727 427 HOH HOH A . 
R 7 HOH 328 728 413 HOH HOH A . 
R 7 HOH 329 729 522 HOH HOH A . 
R 7 HOH 330 730 770 HOH HOH A . 
R 7 HOH 331 731 512 HOH HOH A . 
R 7 HOH 332 732 416 HOH HOH A . 
R 7 HOH 333 733 546 HOH HOH A . 
R 7 HOH 334 734 879 HOH HOH A . 
R 7 HOH 335 735 806 HOH HOH A . 
R 7 HOH 336 736 863 HOH HOH A . 
R 7 HOH 337 737 696 HOH HOH A . 
S 7 HOH 1   401 562 HOH HOH B . 
S 7 HOH 2   402 332 HOH HOH B . 
S 7 HOH 3   403 1   HOH HOH B . 
S 7 HOH 4   404 243 HOH HOH B . 
S 7 HOH 5   405 390 HOH HOH B . 
S 7 HOH 6   406 220 HOH HOH B . 
S 7 HOH 7   407 375 HOH HOH B . 
S 7 HOH 8   408 576 HOH HOH B . 
S 7 HOH 9   409 299 HOH HOH B . 
S 7 HOH 10  410 164 HOH HOH B . 
S 7 HOH 11  411 170 HOH HOH B . 
S 7 HOH 12  412 329 HOH HOH B . 
S 7 HOH 13  413 264 HOH HOH B . 
S 7 HOH 14  414 333 HOH HOH B . 
S 7 HOH 15  415 142 HOH HOH B . 
S 7 HOH 16  416 626 HOH HOH B . 
S 7 HOH 17  417 292 HOH HOH B . 
S 7 HOH 18  418 153 HOH HOH B . 
S 7 HOH 19  419 651 HOH HOH B . 
S 7 HOH 20  420 595 HOH HOH B . 
S 7 HOH 21  421 646 HOH HOH B . 
S 7 HOH 22  422 417 HOH HOH B . 
S 7 HOH 23  423 309 HOH HOH B . 
S 7 HOH 24  424 445 HOH HOH B . 
S 7 HOH 25  425 392 HOH HOH B . 
S 7 HOH 26  426 331 HOH HOH B . 
S 7 HOH 27  427 289 HOH HOH B . 
S 7 HOH 28  428 86  HOH HOH B . 
S 7 HOH 29  429 193 HOH HOH B . 
S 7 HOH 30  430 163 HOH HOH B . 
S 7 HOH 31  431 360 HOH HOH B . 
S 7 HOH 32  432 252 HOH HOH B . 
S 7 HOH 33  433 244 HOH HOH B . 
S 7 HOH 34  434 291 HOH HOH B . 
S 7 HOH 35  435 99  HOH HOH B . 
S 7 HOH 36  436 307 HOH HOH B . 
S 7 HOH 37  437 206 HOH HOH B . 
S 7 HOH 38  438 82  HOH HOH B . 
S 7 HOH 39  439 27  HOH HOH B . 
S 7 HOH 40  440 75  HOH HOH B . 
S 7 HOH 41  441 284 HOH HOH B . 
S 7 HOH 42  442 334 HOH HOH B . 
S 7 HOH 43  443 128 HOH HOH B . 
S 7 HOH 44  444 281 HOH HOH B . 
S 7 HOH 45  445 124 HOH HOH B . 
S 7 HOH 46  446 258 HOH HOH B . 
S 7 HOH 47  447 588 HOH HOH B . 
S 7 HOH 48  448 266 HOH HOH B . 
S 7 HOH 49  449 22  HOH HOH B . 
S 7 HOH 50  450 465 HOH HOH B . 
S 7 HOH 51  451 98  HOH HOH B . 
S 7 HOH 52  452 475 HOH HOH B . 
S 7 HOH 53  453 340 HOH HOH B . 
S 7 HOH 54  454 378 HOH HOH B . 
S 7 HOH 55  455 46  HOH HOH B . 
S 7 HOH 56  456 160 HOH HOH B . 
S 7 HOH 57  457 188 HOH HOH B . 
S 7 HOH 58  458 52  HOH HOH B . 
S 7 HOH 59  459 24  HOH HOH B . 
S 7 HOH 60  460 48  HOH HOH B . 
S 7 HOH 61  461 122 HOH HOH B . 
S 7 HOH 62  462 85  HOH HOH B . 
S 7 HOH 63  463 321 HOH HOH B . 
S 7 HOH 64  464 515 HOH HOH B . 
S 7 HOH 65  465 379 HOH HOH B . 
S 7 HOH 66  466 49  HOH HOH B . 
S 7 HOH 67  467 58  HOH HOH B . 
S 7 HOH 68  468 226 HOH HOH B . 
S 7 HOH 69  469 76  HOH HOH B . 
S 7 HOH 70  470 36  HOH HOH B . 
S 7 HOH 71  471 18  HOH HOH B . 
S 7 HOH 72  472 57  HOH HOH B . 
S 7 HOH 73  473 4   HOH HOH B . 
S 7 HOH 74  474 139 HOH HOH B . 
S 7 HOH 75  475 267 HOH HOH B . 
S 7 HOH 76  476 304 HOH HOH B . 
S 7 HOH 77  477 550 HOH HOH B . 
S 7 HOH 78  478 346 HOH HOH B . 
S 7 HOH 79  479 184 HOH HOH B . 
S 7 HOH 80  480 41  HOH HOH B . 
S 7 HOH 81  481 118 HOH HOH B . 
S 7 HOH 82  482 470 HOH HOH B . 
S 7 HOH 83  483 80  HOH HOH B . 
S 7 HOH 84  484 151 HOH HOH B . 
S 7 HOH 85  485 32  HOH HOH B . 
S 7 HOH 86  486 79  HOH HOH B . 
S 7 HOH 87  487 8   HOH HOH B . 
S 7 HOH 88  488 78  HOH HOH B . 
S 7 HOH 89  489 212 HOH HOH B . 
S 7 HOH 90  490 598 HOH HOH B . 
S 7 HOH 91  491 12  HOH HOH B . 
S 7 HOH 92  492 190 HOH HOH B . 
S 7 HOH 93  493 93  HOH HOH B . 
S 7 HOH 94  494 423 HOH HOH B . 
S 7 HOH 95  495 642 HOH HOH B . 
S 7 HOH 96  496 310 HOH HOH B . 
S 7 HOH 97  497 72  HOH HOH B . 
S 7 HOH 98  498 71  HOH HOH B . 
S 7 HOH 99  499 357 HOH HOH B . 
S 7 HOH 100 500 168 HOH HOH B . 
S 7 HOH 101 501 203 HOH HOH B . 
S 7 HOH 102 502 881 HOH HOH B . 
S 7 HOH 103 503 577 HOH HOH B . 
S 7 HOH 104 504 191 HOH HOH B . 
S 7 HOH 105 505 296 HOH HOH B . 
S 7 HOH 106 506 167 HOH HOH B . 
S 7 HOH 107 507 308 HOH HOH B . 
S 7 HOH 108 508 4   HOH HOH B . 
S 7 HOH 109 509 23  HOH HOH B . 
S 7 HOH 110 510 3   HOH HOH B . 
S 7 HOH 111 511 785 HOH HOH B . 
S 7 HOH 112 512 67  HOH HOH B . 
S 7 HOH 113 513 62  HOH HOH B . 
S 7 HOH 114 514 444 HOH HOH B . 
S 7 HOH 115 515 425 HOH HOH B . 
S 7 HOH 116 516 37  HOH HOH B . 
S 7 HOH 117 517 92  HOH HOH B . 
S 7 HOH 118 518 672 HOH HOH B . 
S 7 HOH 119 519 385 HOH HOH B . 
S 7 HOH 120 520 227 HOH HOH B . 
S 7 HOH 121 521 162 HOH HOH B . 
S 7 HOH 122 522 14  HOH HOH B . 
S 7 HOH 123 523 195 HOH HOH B . 
S 7 HOH 124 524 13  HOH HOH B . 
S 7 HOH 125 525 182 HOH HOH B . 
S 7 HOH 126 526 87  HOH HOH B . 
S 7 HOH 127 527 104 HOH HOH B . 
S 7 HOH 128 528 211 HOH HOH B . 
S 7 HOH 129 529 487 HOH HOH B . 
S 7 HOH 130 530 575 HOH HOH B . 
S 7 HOH 131 531 28  HOH HOH B . 
S 7 HOH 132 532 359 HOH HOH B . 
S 7 HOH 133 533 343 HOH HOH B . 
S 7 HOH 134 534 123 HOH HOH B . 
S 7 HOH 135 535 469 HOH HOH B . 
S 7 HOH 136 536 420 HOH HOH B . 
S 7 HOH 137 537 181 HOH HOH B . 
S 7 HOH 138 538 158 HOH HOH B . 
S 7 HOH 139 539 117 HOH HOH B . 
S 7 HOH 140 540 169 HOH HOH B . 
S 7 HOH 141 541 30  HOH HOH B . 
S 7 HOH 142 542 222 HOH HOH B . 
S 7 HOH 143 543 9   HOH HOH B . 
S 7 HOH 144 544 805 HOH HOH B . 
S 7 HOH 145 545 303 HOH HOH B . 
S 7 HOH 146 546 91  HOH HOH B . 
S 7 HOH 147 547 14  HOH HOH B . 
S 7 HOH 148 548 386 HOH HOH B . 
S 7 HOH 149 549 916 HOH HOH B . 
S 7 HOH 150 550 180 HOH HOH B . 
S 7 HOH 151 551 112 HOH HOH B . 
S 7 HOH 152 552 69  HOH HOH B . 
S 7 HOH 153 553 337 HOH HOH B . 
S 7 HOH 154 554 34  HOH HOH B . 
S 7 HOH 155 555 132 HOH HOH B . 
S 7 HOH 156 556 397 HOH HOH B . 
S 7 HOH 157 557 285 HOH HOH B . 
S 7 HOH 158 558 435 HOH HOH B . 
S 7 HOH 159 559 318 HOH HOH B . 
S 7 HOH 160 560 218 HOH HOH B . 
S 7 HOH 161 561 173 HOH HOH B . 
S 7 HOH 162 562 141 HOH HOH B . 
S 7 HOH 163 563 186 HOH HOH B . 
S 7 HOH 164 564 505 HOH HOH B . 
S 7 HOH 165 565 7   HOH HOH B . 
S 7 HOH 166 566 255 HOH HOH B . 
S 7 HOH 167 567 237 HOH HOH B . 
S 7 HOH 168 568 556 HOH HOH B . 
S 7 HOH 169 569 579 HOH HOH B . 
S 7 HOH 170 570 439 HOH HOH B . 
S 7 HOH 171 571 447 HOH HOH B . 
S 7 HOH 172 572 119 HOH HOH B . 
S 7 HOH 173 573 103 HOH HOH B . 
S 7 HOH 174 574 50  HOH HOH B . 
S 7 HOH 175 575 131 HOH HOH B . 
S 7 HOH 176 576 121 HOH HOH B . 
S 7 HOH 177 577 511 HOH HOH B . 
S 7 HOH 178 578 259 HOH HOH B . 
S 7 HOH 179 579 84  HOH HOH B . 
S 7 HOH 180 580 242 HOH HOH B . 
S 7 HOH 181 581 627 HOH HOH B . 
S 7 HOH 182 582 526 HOH HOH B . 
S 7 HOH 183 583 320 HOH HOH B . 
S 7 HOH 184 584 39  HOH HOH B . 
S 7 HOH 185 585 114 HOH HOH B . 
S 7 HOH 186 586 419 HOH HOH B . 
S 7 HOH 187 587 345 HOH HOH B . 
S 7 HOH 188 588 400 HOH HOH B . 
S 7 HOH 189 589 344 HOH HOH B . 
S 7 HOH 190 590 534 HOH HOH B . 
S 7 HOH 191 591 178 HOH HOH B . 
S 7 HOH 192 592 383 HOH HOH B . 
S 7 HOH 193 593 376 HOH HOH B . 
S 7 HOH 194 594 64  HOH HOH B . 
S 7 HOH 195 595 60  HOH HOH B . 
S 7 HOH 196 596 549 HOH HOH B . 
S 7 HOH 197 597 352 HOH HOH B . 
S 7 HOH 198 598 113 HOH HOH B . 
S 7 HOH 199 599 426 HOH HOH B . 
S 7 HOH 200 600 183 HOH HOH B . 
S 7 HOH 201 601 230 HOH HOH B . 
S 7 HOH 202 602 361 HOH HOH B . 
S 7 HOH 203 603 207 HOH HOH B . 
S 7 HOH 204 604 641 HOH HOH B . 
S 7 HOH 205 605 401 HOH HOH B . 
S 7 HOH 206 606 368 HOH HOH B . 
S 7 HOH 207 607 384 HOH HOH B . 
S 7 HOH 208 608 199 HOH HOH B . 
S 7 HOH 209 609 452 HOH HOH B . 
S 7 HOH 210 610 569 HOH HOH B . 
S 7 HOH 211 611 16  HOH HOH B . 
S 7 HOH 212 612 554 HOH HOH B . 
S 7 HOH 213 613 236 HOH HOH B . 
S 7 HOH 214 614 152 HOH HOH B . 
S 7 HOH 215 615 149 HOH HOH B . 
S 7 HOH 216 616 541 HOH HOH B . 
S 7 HOH 217 617 609 HOH HOH B . 
S 7 HOH 218 618 525 HOH HOH B . 
S 7 HOH 219 619 464 HOH HOH B . 
S 7 HOH 220 620 765 HOH HOH B . 
S 7 HOH 221 621 734 HOH HOH B . 
S 7 HOH 222 622 372 HOH HOH B . 
S 7 HOH 223 623 495 HOH HOH B . 
S 7 HOH 224 624 502 HOH HOH B . 
S 7 HOH 225 625 488 HOH HOH B . 
S 7 HOH 226 626 382 HOH HOH B . 
S 7 HOH 227 627 185 HOH HOH B . 
S 7 HOH 228 628 561 HOH HOH B . 
S 7 HOH 229 629 224 HOH HOH B . 
S 7 HOH 230 630 547 HOH HOH B . 
S 7 HOH 231 631 144 HOH HOH B . 
S 7 HOH 232 632 539 HOH HOH B . 
S 7 HOH 233 633 120 HOH HOH B . 
S 7 HOH 234 634 520 HOH HOH B . 
S 7 HOH 235 635 192 HOH HOH B . 
S 7 HOH 236 636 551 HOH HOH B . 
S 7 HOH 237 637 436 HOH HOH B . 
S 7 HOH 238 638 197 HOH HOH B . 
S 7 HOH 239 639 619 HOH HOH B . 
S 7 HOH 240 640 768 HOH HOH B . 
S 7 HOH 241 641 730 HOH HOH B . 
S 7 HOH 242 642 801 HOH HOH B . 
S 7 HOH 243 643 295 HOH HOH B . 
S 7 HOH 244 644 910 HOH HOH B . 
S 7 HOH 245 645 240 HOH HOH B . 
S 7 HOH 246 646 157 HOH HOH B . 
S 7 HOH 247 647 349 HOH HOH B . 
S 7 HOH 248 648 404 HOH HOH B . 
S 7 HOH 249 649 521 HOH HOH B . 
S 7 HOH 250 650 251 HOH HOH B . 
S 7 HOH 251 651 3   HOH HOH B . 
S 7 HOH 252 652 602 HOH HOH B . 
S 7 HOH 253 653 519 HOH HOH B . 
S 7 HOH 254 654 430 HOH HOH B . 
S 7 HOH 255 655 412 HOH HOH B . 
S 7 HOH 256 656 507 HOH HOH B . 
S 7 HOH 257 657 586 HOH HOH B . 
S 7 HOH 258 658 597 HOH HOH B . 
S 7 HOH 259 659 438 HOH HOH B . 
S 7 HOH 260 660 460 HOH HOH B . 
S 7 HOH 261 661 925 HOH HOH B . 
S 7 HOH 262 662 338 HOH HOH B . 
S 7 HOH 263 663 528 HOH HOH B . 
S 7 HOH 264 664 827 HOH HOH B . 
S 7 HOH 265 665 138 HOH HOH B . 
S 7 HOH 266 666 650 HOH HOH B . 
S 7 HOH 267 667 269 HOH HOH B . 
S 7 HOH 268 668 584 HOH HOH B . 
S 7 HOH 269 669 187 HOH HOH B . 
S 7 HOH 270 670 377 HOH HOH B . 
S 7 HOH 271 671 731 HOH HOH B . 
S 7 HOH 272 672 918 HOH HOH B . 
S 7 HOH 273 673 682 HOH HOH B . 
S 7 HOH 274 674 446 HOH HOH B . 
S 7 HOH 275 675 472 HOH HOH B . 
S 7 HOH 276 676 640 HOH HOH B . 
S 7 HOH 277 677 366 HOH HOH B . 
S 7 HOH 278 678 625 HOH HOH B . 
S 7 HOH 279 679 274 HOH HOH B . 
S 7 HOH 280 680 888 HOH HOH B . 
S 7 HOH 281 681 403 HOH HOH B . 
S 7 HOH 282 682 214 HOH HOH B . 
S 7 HOH 283 683 661 HOH HOH B . 
S 7 HOH 284 684 277 HOH HOH B . 
S 7 HOH 285 685 440 HOH HOH B . 
S 7 HOH 286 686 529 HOH HOH B . 
S 7 HOH 287 687 324 HOH HOH B . 
S 7 HOH 288 688 608 HOH HOH B . 
S 7 HOH 289 689 275 HOH HOH B . 
S 7 HOH 290 690 663 HOH HOH B . 
S 7 HOH 291 691 213 HOH HOH B . 
S 7 HOH 292 692 393 HOH HOH B . 
S 7 HOH 293 693 779 HOH HOH B . 
S 7 HOH 294 694 293 HOH HOH B . 
S 7 HOH 295 695 221 HOH HOH B . 
S 7 HOH 296 696 422 HOH HOH B . 
S 7 HOH 297 697 570 HOH HOH B . 
S 7 HOH 298 698 491 HOH HOH B . 
S 7 HOH 299 699 286 HOH HOH B . 
S 7 HOH 300 700 317 HOH HOH B . 
S 7 HOH 301 701 249 HOH HOH B . 
S 7 HOH 302 702 498 HOH HOH B . 
S 7 HOH 303 703 315 HOH HOH B . 
S 7 HOH 304 704 389 HOH HOH B . 
S 7 HOH 305 705 548 HOH HOH B . 
S 7 HOH 306 706 323 HOH HOH B . 
S 7 HOH 307 707 565 HOH HOH B . 
S 7 HOH 308 708 462 HOH HOH B . 
S 7 HOH 309 709 919 HOH HOH B . 
S 7 HOH 310 710 330 HOH HOH B . 
S 7 HOH 311 711 410 HOH HOH B . 
S 7 HOH 312 712 306 HOH HOH B . 
S 7 HOH 313 713 572 HOH HOH B . 
S 7 HOH 314 714 351 HOH HOH B . 
S 7 HOH 315 715 474 HOH HOH B . 
S 7 HOH 316 716 468 HOH HOH B . 
S 7 HOH 317 717 538 HOH HOH B . 
S 7 HOH 318 718 499 HOH HOH B . 
S 7 HOH 319 719 454 HOH HOH B . 
S 7 HOH 320 720 829 HOH HOH B . 
S 7 HOH 321 721 705 HOH HOH B . 
S 7 HOH 322 722 621 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .    4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQ2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     75.113 
_cell.length_a_esd                 ? 
_cell.length_b                     78.836 
_cell.length_b_esd                 ? 
_cell.length_c                     97.166 
_cell.length_c_esd                 ? 
_cell.volume                       575379.008 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQ2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQ2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.71 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.68 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M NaBr; 20% (w/v) PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-06-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97946 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97946 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          12.73 
_reflns.entry_id                                       9DQ2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.55 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     84079 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                11.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.976 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.172 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.172 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.55 
_reflns_shell.d_res_low                                     1.58 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4147 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.976 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               18.46 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQ2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.55 
_refine.ls_d_res_low                             41.36 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     81626 
_refine.ls_number_reflns_R_free                  4007 
_refine.ls_number_reflns_R_work                  77619 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.86 
_refine.ls_percent_reflns_R_free                 4.91 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1965 
_refine.ls_R_factor_R_free                       0.2111 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1957 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.2236 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1698 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.55 
_refine_hist.d_res_low                        41.36 
_refine_hist.number_atoms_solvent             659 
_refine_hist.number_atoms_total               4301 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3564 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         78 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0099  ? 3855 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2087  ? 5254 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0754  ? 546  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0138  ? 702  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.8227 ? 1429 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.55 1.57  . . 140 2285 83.77 . . . . 0.3039 . . . . . . . . . . . 0.3280 
'X-RAY DIFFRACTION' 1.57 1.59  . . 137 2527 93.51 . . . . 0.2535 . . . . . . . . . . . 0.2624 
'X-RAY DIFFRACTION' 1.59 1.61  . . 126 2599 95.51 . . . . 0.2508 . . . . . . . . . . . 0.2964 
'X-RAY DIFFRACTION' 1.61 1.63  . . 136 2681 97.14 . . . . 0.2331 . . . . . . . . . . . 0.2874 
'X-RAY DIFFRACTION' 1.63 1.65  . . 137 2662 97.83 . . . . 0.2194 . . . . . . . . . . . 0.2502 
'X-RAY DIFFRACTION' 1.65 1.67  . . 148 2689 98.13 . . . . 0.2102 . . . . . . . . . . . 0.2412 
'X-RAY DIFFRACTION' 1.67 1.70  . . 143 2682 98.64 . . . . 0.2040 . . . . . . . . . . . 0.2267 
'X-RAY DIFFRACTION' 1.70 1.73  . . 113 2692 98.18 . . . . 0.1958 . . . . . . . . . . . 0.2061 
'X-RAY DIFFRACTION' 1.73 1.75  . . 142 2721 98.28 . . . . 0.1992 . . . . . . . . . . . 0.2249 
'X-RAY DIFFRACTION' 1.75 1.78  . . 113 2693 97.97 . . . . 0.1945 . . . . . . . . . . . 0.2325 
'X-RAY DIFFRACTION' 1.78 1.82  . . 125 2657 97.51 . . . . 0.2028 . . . . . . . . . . . 0.2199 
'X-RAY DIFFRACTION' 1.82 1.85  . . 158 2673 97.86 . . . . 0.2121 . . . . . . . . . . . 0.2256 
'X-RAY DIFFRACTION' 1.85 1.89  . . 148 2675 97.99 . . . . 0.2125 . . . . . . . . . . . 0.2369 
'X-RAY DIFFRACTION' 1.89 1.93  . . 179 2617 97.02 . . . . 0.2129 . . . . . . . . . . . 0.2057 
'X-RAY DIFFRACTION' 1.93 1.98  . . 132 2676 96.53 . . . . 0.1834 . . . . . . . . . . . 0.2171 
'X-RAY DIFFRACTION' 1.98 2.03  . . 145 2657 96.85 . . . . 0.1878 . . . . . . . . . . . 0.2022 
'X-RAY DIFFRACTION' 2.03 2.08  . . 165 2646 96.90 . . . . 0.1838 . . . . . . . . . . . 0.1860 
'X-RAY DIFFRACTION' 2.08 2.14  . . 156 2649 97.63 . . . . 0.1806 . . . . . . . . . . . 0.2079 
'X-RAY DIFFRACTION' 2.14 2.21  . . 142 2688 97.45 . . . . 0.1885 . . . . . . . . . . . 0.2226 
'X-RAY DIFFRACTION' 2.21 2.29  . . 121 2691 97.54 . . . . 0.1818 . . . . . . . . . . . 0.2148 
'X-RAY DIFFRACTION' 2.29 2.38  . . 122 2708 97.38 . . . . 0.1810 . . . . . . . . . . . 0.1927 
'X-RAY DIFFRACTION' 2.38 2.49  . . 137 2693 96.98 . . . . 0.1998 . . . . . . . . . . . 0.2226 
'X-RAY DIFFRACTION' 2.49 2.62  . . 131 2703 96.72 . . . . 0.2010 . . . . . . . . . . . 0.2603 
'X-RAY DIFFRACTION' 2.62 2.78  . . 102 2745 97.27 . . . . 0.2002 . . . . . . . . . . . 0.2066 
'X-RAY DIFFRACTION' 2.78 3.00  . . 130 2743 98.32 . . . . 0.1922 . . . . . . . . . . . 0.2400 
'X-RAY DIFFRACTION' 3.00 3.30  . . 138 2753 97.73 . . . . 0.1930 . . . . . . . . . . . 0.1939 
'X-RAY DIFFRACTION' 3.30 3.78  . . 137 2741 97.23 . . . . 0.1782 . . . . . . . . . . . 0.1843 
'X-RAY DIFFRACTION' 3.78 4.76  . . 153 2759 97.39 . . . . 0.1720 . . . . . . . . . . . 0.1610 
'X-RAY DIFFRACTION' 4.76 41.36 . . 151 2914 97.61 . . . . 0.2107 . . . . . . . . . . . 0.1989 
# 
_struct.entry_id                     9DQ2 
_struct.title                        
'Crystal structure of HrmJ from Streptomyces sp. CFMR 7 (HrmJ-ssc) complexed with vanadyl(IV)-oxo, succinate and 6-nitronorleucine' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQ2 
_struct_keywords.text            'cyclopropanase, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
H N N 6 ? 
I N N 6 ? 
J N N 6 ? 
K N N 2 ? 
L N N 3 ? 
M N N 4 ? 
N N N 5 ? 
O N N 5 ? 
P N N 5 ? 
Q N N 6 ? 
R N N 7 ? 
S N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0M5J3M0_9ACTN 
_struct_ref.pdbx_db_accession          A0A0M5J3M0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQ2 A 1 ? 230 ? A0A0M5J3M0 1 ? 230 ? 1 230 
2 1 9DQ2 B 1 ? 230 ? A0A0M5J3M0 1 ? 230 ? 1 230 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQ2 HIS A 231 ? UNP A0A0M5J3M0 ? ? 'expression tag' 231 1  
1 9DQ2 HIS A 232 ? UNP A0A0M5J3M0 ? ? 'expression tag' 232 2  
1 9DQ2 HIS A 233 ? UNP A0A0M5J3M0 ? ? 'expression tag' 233 3  
1 9DQ2 HIS A 234 ? UNP A0A0M5J3M0 ? ? 'expression tag' 234 4  
1 9DQ2 HIS A 235 ? UNP A0A0M5J3M0 ? ? 'expression tag' 235 5  
1 9DQ2 HIS A 236 ? UNP A0A0M5J3M0 ? ? 'expression tag' 236 6  
2 9DQ2 HIS B 231 ? UNP A0A0M5J3M0 ? ? 'expression tag' 231 7  
2 9DQ2 HIS B 232 ? UNP A0A0M5J3M0 ? ? 'expression tag' 232 8  
2 9DQ2 HIS B 233 ? UNP A0A0M5J3M0 ? ? 'expression tag' 233 9  
2 9DQ2 HIS B 234 ? UNP A0A0M5J3M0 ? ? 'expression tag' 234 10 
2 9DQ2 HIS B 235 ? UNP A0A0M5J3M0 ? ? 'expression tag' 235 11 
2 9DQ2 HIS B 236 ? UNP A0A0M5J3M0 ? ? 'expression tag' 236 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 19  ? TYR A 24  ? ASP A 19  TYR A 24  1 ? 6  
HELX_P HELX_P2  AA2 ASP A 25  ? CYS A 27  ? ASP A 25  CYS A 27  5 ? 3  
HELX_P HELX_P3  AA3 PHE A 89  ? GLY A 101 ? PHE A 89  GLY A 101 1 ? 13 
HELX_P HELX_P4  AA4 ALA A 212 ? LYS A 214 ? ALA A 212 LYS A 214 5 ? 3  
HELX_P HELX_P5  AA5 GLY A 217 ? GLU A 226 ? GLY A 217 GLU A 226 1 ? 10 
HELX_P HELX_P6  AA6 ASP B 19  ? TYR B 24  ? ASP B 19  TYR B 24  1 ? 6  
HELX_P HELX_P7  AA7 ASP B 25  ? CYS B 27  ? ASP B 25  CYS B 27  5 ? 3  
HELX_P HELX_P8  AA8 PHE B 89  ? GLY B 101 ? PHE B 89  GLY B 101 1 ? 13 
HELX_P HELX_P9  AA9 ALA B 212 ? LYS B 214 ? ALA B 212 LYS B 214 5 ? 3  
HELX_P HELX_P10 AB1 GLY B 217 ? LEU B 225 ? GLY B 217 LEU B 225 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 133 NE2 ? ? ? 1_555 D VVO . V1 ? ? A HIS 133 A VVO 302 1_555 ? ? ? ? ? ? ? 2.216 ? ? 
metalc2  metalc ? ? A ASP 135 OD1 ? ? ? 1_555 D VVO . V1 ? ? A ASP 135 A VVO 302 1_555 ? ? ? ? ? ? ? 2.165 ? ? 
metalc3  metalc ? ? A HIS 186 NE2 ? ? ? 1_555 D VVO . V1 ? ? A HIS 186 A VVO 302 1_555 ? ? ? ? ? ? ? 2.303 ? ? 
metalc4  metalc ? ? D VVO .   V1  ? ? ? 1_555 E SIN . O1 ? ? A VVO 302 A SIN 303 1_555 ? ? ? ? ? ? ? 2.090 ? ? 
metalc5  metalc ? ? D VVO .   V1  ? ? ? 1_555 R HOH . O  ? ? A VVO 302 A HOH 419 1_555 ? ? ? ? ? ? ? 2.213 ? ? 
metalc6  metalc ? ? B HIS 133 NE2 ? ? ? 1_555 L VVO . V1 ? ? B HIS 133 B VVO 302 1_555 ? ? ? ? ? ? ? 2.246 ? ? 
metalc7  metalc ? ? B ASP 135 OD1 ? ? ? 1_555 L VVO . V1 ? ? B ASP 135 B VVO 302 1_555 ? ? ? ? ? ? ? 2.132 ? ? 
metalc8  metalc ? ? B HIS 186 NE2 ? ? ? 1_555 L VVO . V1 ? ? B HIS 186 B VVO 302 1_555 ? ? ? ? ? ? ? 2.284 ? ? 
metalc9  metalc ? ? L VVO .   V1  ? ? ? 1_555 M SIN . O3 ? ? B VVO 302 B SIN 303 1_555 ? ? ? ? ? ? ? 2.138 ? ? 
metalc10 metalc ? ? L VVO .   V1  ? ? ? 1_555 S HOH . O  ? ? B VVO 302 B HOH 428 1_555 ? ? ? ? ? ? ? 2.099 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 133 ? A HIS 133 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? D VVO .   ? A VVO 302 ? 1_555 91.8  ? 
2  NE2 ? A HIS 133 ? A HIS 133 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 OD1 ? A ASP 135 ? A ASP 135 ? 1_555 88.8  ? 
3  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 OD1 ? A ASP 135 ? A ASP 135 ? 1_555 95.9  ? 
4  NE2 ? A HIS 133 ? A HIS 133 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 186 ? A HIS 186 ? 1_555 82.5  ? 
5  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 186 ? A HIS 186 ? 1_555 172.1 ? 
6  OD1 ? A ASP 135 ? A ASP 135 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 NE2 ? A HIS 186 ? A HIS 186 ? 1_555 89.5  ? 
7  NE2 ? A HIS 133 ? A HIS 133 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? E SIN .   ? A SIN 303 ? 1_555 95.0  ? 
8  O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? E SIN .   ? A SIN 303 ? 1_555 91.3  ? 
9  OD1 ? A ASP 135 ? A ASP 135 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? E SIN .   ? A SIN 303 ? 1_555 171.8 ? 
10 NE2 ? A HIS 186 ? A HIS 186 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O1  ? E SIN .   ? A SIN 303 ? 1_555 83.7  ? 
11 NE2 ? A HIS 133 ? A HIS 133 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? R HOH .   ? A HOH 419 ? 1_555 169.9 ? 
12 O1  ? D VVO .   ? A VVO 302 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? R HOH .   ? A HOH 419 ? 1_555 97.4  ? 
13 OD1 ? A ASP 135 ? A ASP 135 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? R HOH .   ? A HOH 419 ? 1_555 86.2  ? 
14 NE2 ? A HIS 186 ? A HIS 186 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? R HOH .   ? A HOH 419 ? 1_555 88.7  ? 
15 O1  ? E SIN .   ? A SIN 303 ? 1_555 V1 ? D VVO . ? A VVO 302 ? 1_555 O   ? R HOH .   ? A HOH 419 ? 1_555 88.8  ? 
16 NE2 ? B HIS 133 ? B HIS 133 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O1  ? L VVO .   ? B VVO 302 ? 1_555 91.6  ? 
17 NE2 ? B HIS 133 ? B HIS 133 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 135 ? B ASP 135 ? 1_555 90.0  ? 
18 O1  ? L VVO .   ? B VVO 302 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 OD1 ? B ASP 135 ? B ASP 135 ? 1_555 95.6  ? 
19 NE2 ? B HIS 133 ? B HIS 133 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 186 ? B HIS 186 ? 1_555 81.4  ? 
20 O1  ? L VVO .   ? B VVO 302 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 186 ? B HIS 186 ? 1_555 171.6 ? 
21 OD1 ? B ASP 135 ? B ASP 135 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 NE2 ? B HIS 186 ? B HIS 186 ? 1_555 89.1  ? 
22 NE2 ? B HIS 133 ? B HIS 133 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O3  ? M SIN .   ? B SIN 303 ? 1_555 91.3  ? 
23 O1  ? L VVO .   ? B VVO 302 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O3  ? M SIN .   ? B SIN 303 ? 1_555 90.6  ? 
24 OD1 ? B ASP 135 ? B ASP 135 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O3  ? M SIN .   ? B SIN 303 ? 1_555 173.7 ? 
25 NE2 ? B HIS 186 ? B HIS 186 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O3  ? M SIN .   ? B SIN 303 ? 1_555 85.0  ? 
26 NE2 ? B HIS 133 ? B HIS 133 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O   ? S HOH .   ? B HOH 428 ? 1_555 169.2 ? 
27 O1  ? L VVO .   ? B VVO 302 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O   ? S HOH .   ? B HOH 428 ? 1_555 99.2  ? 
28 OD1 ? B ASP 135 ? B ASP 135 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O   ? S HOH .   ? B HOH 428 ? 1_555 87.6  ? 
29 NE2 ? B HIS 186 ? B HIS 186 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O   ? S HOH .   ? B HOH 428 ? 1_555 88.0  ? 
30 O3  ? M SIN .   ? B SIN 303 ? 1_555 V1 ? L VVO . ? B VVO 302 ? 1_555 O   ? S HOH .   ? B HOH 428 ? 1_555 90.0  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? ASP A 12  ? PHE A 8   ASP A 12  
AA1 2 GLN A 175 ? ASP A 180 ? GLN A 175 ASP A 180 
AA1 3 PHE A 139 ? VAL A 148 ? PHE A 139 VAL A 148 
AA1 4 GLY A 199 ? ARG A 210 ? GLY A 199 ARG A 210 
AA1 5 TRP A 108 ? ALA A 119 ? TRP A 108 ALA A 119 
AA1 6 ARG A 38  ? ALA A 50  ? ARG A 38  ALA A 50  
AA1 7 THR A 54  ? ARG A 59  ? THR A 54  ARG A 59  
AA2 1 VAL A 150 ? GLY A 152 ? VAL A 150 GLY A 152 
AA2 2 VAL A 191 ? SER A 193 ? VAL A 191 SER A 193 
AA3 1 TRP A 167 ? THR A 170 ? TRP A 167 THR A 170 
AA3 2 THR A 154 ? TRP A 158 ? THR A 154 TRP A 158 
AA3 3 ALA A 185 ? VAL A 188 ? ALA A 185 VAL A 188 
AA4 1 PHE B 8   ? ASP B 12  ? PHE B 8   ASP B 12  
AA4 2 GLN B 175 ? ASP B 180 ? GLN B 175 ASP B 180 
AA4 3 PHE B 139 ? VAL B 148 ? PHE B 139 VAL B 148 
AA4 4 GLY B 199 ? ARG B 210 ? GLY B 199 ARG B 210 
AA4 5 TRP B 108 ? ALA B 119 ? TRP B 108 ALA B 119 
AA4 6 ARG B 38  ? ALA B 50  ? ARG B 38  ALA B 50  
AA4 7 THR B 54  ? ARG B 59  ? THR B 54  ARG B 59  
AA5 1 VAL B 150 ? GLY B 152 ? VAL B 150 GLY B 152 
AA5 2 VAL B 191 ? SER B 193 ? VAL B 191 SER B 193 
AA6 1 TRP B 167 ? THR B 170 ? TRP B 167 THR B 170 
AA6 2 THR B 154 ? TRP B 158 ? THR B 154 TRP B 158 
AA6 3 ALA B 185 ? VAL B 188 ? ALA B 185 VAL B 188 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 11  ? N ILE A 11  O ALA A 176 ? O ALA A 176 
AA1 2 3 O GLN A 175 ? O GLN A 175 N ILE A 144 ? N ILE A 144 
AA1 3 4 N ASN A 146 ? N ASN A 146 O ASP A 202 ? O ASP A 202 
AA1 4 5 O SER A 209 ? O SER A 209 N GLN A 109 ? N GLN A 109 
AA1 5 6 O TRP A 108 ? O TRP A 108 N LEU A 47  ? N LEU A 47  
AA1 6 7 N ALA A 50  ? N ALA A 50  O THR A 54  ? O THR A 54  
AA2 1 2 N ALA A 151 ? N ALA A 151 O LEU A 192 ? O LEU A 192 
AA3 1 2 O TRP A 167 ? O TRP A 167 N LEU A 157 ? N LEU A 157 
AA3 2 3 N ARG A 156 ? N ARG A 156 O ASP A 187 ? O ASP A 187 
AA4 1 2 N THR B 9   ? N THR B 9   O LEU B 178 ? O LEU B 178 
AA4 2 3 O GLN B 175 ? O GLN B 175 N ILE B 144 ? N ILE B 144 
AA4 3 4 N ASN B 146 ? N ASN B 146 O ASP B 202 ? O ASP B 202 
AA4 4 5 O SER B 209 ? O SER B 209 N GLN B 109 ? N GLN B 109 
AA4 5 6 O TRP B 108 ? O TRP B 108 N LEU B 47  ? N LEU B 47  
AA4 6 7 N THR B 48  ? N THR B 48  O SER B 56  ? O SER B 56  
AA5 1 2 N ALA B 151 ? N ALA B 151 O LEU B 192 ? O LEU B 192 
AA6 1 2 O TRP B 167 ? O TRP B 167 N LEU B 157 ? N LEU B 157 
AA6 2 3 N ARG B 156 ? N ARG B 156 O ASP B 187 ? O ASP B 187 
# 
_pdbx_entry_details.entry_id                   9DQ2 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 NH2 A ARG 79  ? B O A HOH 401 ? ? 1.65 
2  1 OE1 A GLU 6   ? ? O A HOH 402 ? ? 1.66 
3  1 OE1 B GLU 6   ? ? O B HOH 401 ? ? 1.74 
4  1 O   A HOH 588 ? ? O A HOH 676 ? ? 1.75 
5  1 O   A HOH 561 ? ? O A HOH 673 ? ? 1.75 
6  1 O   A LEU 3   ? ? O A HOH 403 ? ? 1.78 
7  1 O   B HOH 431 ? ? O B HOH 465 ? ? 1.79 
8  1 O   B HOH 530 ? ? O B HOH 628 ? ? 1.80 
9  1 O   A HOH 567 ? ? O A HOH 647 ? ? 1.82 
10 1 NH1 A ARG 118 ? ? O A HOH 404 ? ? 1.83 
11 1 OE1 A GLU 226 ? ? O A HOH 405 ? ? 1.84 
12 1 O   A HOH 651 ? ? O A HOH 660 ? ? 1.84 
13 1 O   A HOH 705 ? ? O A HOH 724 ? ? 1.85 
14 1 O   A HOH 580 ? ? O A HOH 583 ? ? 1.87 
15 1 O   B HOH 627 ? ? O B HOH 698 ? ? 1.87 
16 1 OG  B SER 105 ? ? O B HOH 402 ? ? 1.88 
17 1 OE1 B GLU 226 ? ? O B HOH 403 ? ? 1.88 
18 1 NZ  A LYS 58  ? ? O A HOH 406 ? ? 1.89 
19 1 O   A HOH 570 ? ? O A HOH 691 ? ? 1.89 
20 1 O   B HOH 416 ? ? O B HOH 620 ? ? 1.89 
21 1 O   B HOH 569 ? ? O B HOH 644 ? ? 1.90 
22 1 O   A HOH 547 ? ? O A HOH 636 ? ? 1.91 
23 1 OG  A SER 56  ? ? O A HOH 407 ? ? 1.92 
24 1 OE1 A GLU 227 ? ? O A HOH 408 ? ? 1.92 
25 1 BR  A BR  306 ? ? O A HOH 643 ? ? 1.93 
26 1 O   A HOH 646 ? ? O A HOH 716 ? ? 1.95 
27 1 O   B HOH 668 ? ? O B HOH 683 ? ? 1.96 
28 1 O   A HOH 471 ? ? O A HOH 518 ? ? 1.96 
29 1 NH2 B ARG 79  ? B O B HOH 404 ? ? 2.00 
30 1 O   A HOH 535 ? ? O A HOH 628 ? ? 2.01 
31 1 O   B HOH 657 ? ? O B HOH 702 ? ? 2.02 
32 1 O   B HOH 684 ? ? O B HOH 710 ? ? 2.03 
33 1 O   A HOH 735 ? ? O A HOH 736 ? ? 2.04 
34 1 O   A HOH 625 ? ? O A HOH 629 ? ? 2.04 
35 1 BR  B BR  307 ? ? O B HOH 651 ? ? 2.04 
36 1 O   B HOH 625 ? ? O B HOH 705 ? ? 2.05 
37 1 O   B HOH 665 ? ? O B HOH 698 ? ? 2.05 
38 1 O   A HOH 655 ? ? O A HOH 656 ? ? 2.05 
39 1 O   B HOH 519 ? ? O B HOH 674 ? ? 2.06 
40 1 O   A HOH 573 ? ? O A HOH 677 ? ? 2.07 
41 1 O   B GLU 15  ? ? O B HOH 405 ? ? 2.07 
42 1 O   A HOH 657 ? ? O A HOH 692 ? ? 2.07 
43 1 O   A HOH 411 ? ? O A HOH 427 ? ? 2.09 
44 1 O   A HOH 431 ? ? O A HOH 659 ? ? 2.09 
45 1 OD1 A ASN 146 ? ? O A HOH 409 ? ? 2.09 
46 1 O   B HOH 714 ? ? O B HOH 719 ? ? 2.10 
47 1 O   A HOH 653 ? ? O A HOH 671 ? ? 2.11 
48 1 O   B HOH 619 ? ? O B HOH 712 ? ? 2.11 
49 1 O   A HOH 529 ? ? O A HOH 701 ? ? 2.11 
50 1 O   B HOH 596 ? ? O B HOH 637 ? ? 2.11 
51 1 NH1 B ARG 118 ? A O B HOH 406 ? ? 2.11 
52 1 O   A HOH 708 ? ? O A HOH 723 ? ? 2.12 
53 1 O   B HOH 560 ? ? O B HOH 675 ? ? 2.13 
54 1 O   A HOH 451 ? ? O A HOH 607 ? ? 2.14 
55 1 OG  A SER 105 ? A O A HOH 410 ? ? 2.14 
56 1 O   B HOH 417 ? ? O B HOH 677 ? ? 2.15 
57 1 O   A HOH 645 ? ? O A HOH 664 ? ? 2.16 
58 1 O   A HOH 502 ? ? O A HOH 556 ? ? 2.17 
59 1 O   B HOH 407 ? ? O B HOH 534 ? ? 2.18 
60 1 O   A HOH 606 ? ? O A HOH 704 ? ? 2.19 
61 1 O   B HOH 623 ? ? O B HOH 656 ? ? 2.19 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O  B HOH 415 ? ? 1_555 O B HOH 508 ? ? 3_554 1.85 
2 1 O  A HOH 660 ? ? 1_555 O B HOH 691 ? ? 2_555 1.92 
3 1 O  A HOH 586 ? ? 1_555 O B HOH 537 ? ? 2_455 2.10 
4 1 O  A HOH 696 ? ? 1_555 O B HOH 648 ? ? 2_555 2.13 
5 1 BR A BR  308 ? ? 1_555 O B HOH 636 ? ? 2_455 2.18 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              145 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              145 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              145 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                96.45 
_pdbx_validate_rmsd_angle.angle_target_value         115.30 
_pdbx_validate_rmsd_angle.angle_deviation            -18.85 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.30 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TRP A 215 ? ? -97.42 53.21 
2 1 TRP B 215 ? ? -95.12 53.91 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    B 
_pdbx_validate_planes.auth_seq_id     201 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.083 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1  1 O ? A HOH 726 ? 5.93  . 
2  1 O ? A HOH 727 ? 6.01  . 
3  1 O ? A HOH 728 ? 6.52  . 
4  1 O ? A HOH 729 ? 6.53  . 
5  1 O ? A HOH 730 ? 6.92  . 
6  1 O ? A HOH 731 ? 7.03  . 
7  1 O ? A HOH 732 ? 7.07  . 
8  1 O ? A HOH 733 ? 7.18  . 
9  1 O ? A HOH 734 ? 7.22  . 
10 1 O ? A HOH 735 ? 8.92  . 
11 1 O ? A HOH 736 ? 9.18  . 
12 1 O ? A HOH 737 ? 10.26 . 
13 1 O ? B HOH 714 ? 5.82  . 
14 1 O ? B HOH 715 ? 5.97  . 
15 1 O ? B HOH 716 ? 6.01  . 
16 1 O ? B HOH 717 ? 6.04  . 
17 1 O ? B HOH 718 ? 6.13  . 
18 1 O ? B HOH 719 ? 6.28  . 
19 1 O ? B HOH 720 ? 6.74  . 
20 1 O ? B HOH 721 ? 6.83  . 
21 1 O ? B HOH 722 ? 7.41  . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A GLN 228 ? A GLN 228 
3  1 Y 1 A GLU 229 ? A GLU 229 
4  1 Y 1 A ALA 230 ? A ALA 230 
5  1 Y 1 A HIS 231 ? A HIS 231 
6  1 Y 1 A HIS 232 ? A HIS 232 
7  1 Y 1 A HIS 233 ? A HIS 233 
8  1 Y 1 A HIS 234 ? A HIS 234 
9  1 Y 1 A HIS 235 ? A HIS 235 
10 1 Y 1 A HIS 236 ? A HIS 236 
11 1 Y 1 B MET 1   ? B MET 1   
12 1 Y 1 B GLN 228 ? B GLN 228 
13 1 Y 1 B GLU 229 ? B GLU 229 
14 1 Y 1 B ALA 230 ? B ALA 230 
15 1 Y 1 B HIS 231 ? B HIS 231 
16 1 Y 1 B HIS 232 ? B HIS 232 
17 1 Y 1 B HIS 233 ? B HIS 233 
18 1 Y 1 B HIS 234 ? B HIS 234 
19 1 Y 1 B HIS 235 ? B HIS 235 
20 1 Y 1 B HIS 236 ? B HIS 236 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
6HN N1   N  N N 1   
6HN N    N  N N 2   
6HN CA   C  N S 3   
6HN C    C  N N 4   
6HN OXT  O  N N 5   
6HN O    O  N N 6   
6HN CB   C  N N 7   
6HN CG   C  N N 8   
6HN CD   C  N N 9   
6HN CE   C  N N 10  
6HN O2   O  N N 11  
6HN O1   O  N N 12  
6HN H    H  N N 13  
6HN HN2  H  N N 14  
6HN HA   H  N N 15  
6HN HB   H  N N 16  
6HN HBA  H  N N 17  
6HN HG   H  N N 18  
6HN HGA  H  N N 19  
6HN HD   H  N N 20  
6HN HDA  H  N N 21  
6HN HE   H  N N 22  
6HN HEA  H  N N 23  
6HN HXT  H  N N 24  
ALA N    N  N N 25  
ALA CA   C  N S 26  
ALA C    C  N N 27  
ALA O    O  N N 28  
ALA CB   C  N N 29  
ALA OXT  O  N N 30  
ALA H    H  N N 31  
ALA H2   H  N N 32  
ALA HA   H  N N 33  
ALA HB1  H  N N 34  
ALA HB2  H  N N 35  
ALA HB3  H  N N 36  
ALA HXT  H  N N 37  
ARG N    N  N N 38  
ARG CA   C  N S 39  
ARG C    C  N N 40  
ARG O    O  N N 41  
ARG CB   C  N N 42  
ARG CG   C  N N 43  
ARG CD   C  N N 44  
ARG NE   N  N N 45  
ARG CZ   C  N N 46  
ARG NH1  N  N N 47  
ARG NH2  N  N N 48  
ARG OXT  O  N N 49  
ARG H    H  N N 50  
ARG H2   H  N N 51  
ARG HA   H  N N 52  
ARG HB2  H  N N 53  
ARG HB3  H  N N 54  
ARG HG2  H  N N 55  
ARG HG3  H  N N 56  
ARG HD2  H  N N 57  
ARG HD3  H  N N 58  
ARG HE   H  N N 59  
ARG HH11 H  N N 60  
ARG HH12 H  N N 61  
ARG HH21 H  N N 62  
ARG HH22 H  N N 63  
ARG HXT  H  N N 64  
ASN N    N  N N 65  
ASN CA   C  N S 66  
ASN C    C  N N 67  
ASN O    O  N N 68  
ASN CB   C  N N 69  
ASN CG   C  N N 70  
ASN OD1  O  N N 71  
ASN ND2  N  N N 72  
ASN OXT  O  N N 73  
ASN H    H  N N 74  
ASN H2   H  N N 75  
ASN HA   H  N N 76  
ASN HB2  H  N N 77  
ASN HB3  H  N N 78  
ASN HD21 H  N N 79  
ASN HD22 H  N N 80  
ASN HXT  H  N N 81  
ASP N    N  N N 82  
ASP CA   C  N S 83  
ASP C    C  N N 84  
ASP O    O  N N 85  
ASP CB   C  N N 86  
ASP CG   C  N N 87  
ASP OD1  O  N N 88  
ASP OD2  O  N N 89  
ASP OXT  O  N N 90  
ASP H    H  N N 91  
ASP H2   H  N N 92  
ASP HA   H  N N 93  
ASP HB2  H  N N 94  
ASP HB3  H  N N 95  
ASP HD2  H  N N 96  
ASP HXT  H  N N 97  
BR  BR   BR N N 98  
CYS N    N  N N 99  
CYS CA   C  N R 100 
CYS C    C  N N 101 
CYS O    O  N N 102 
CYS CB   C  N N 103 
CYS SG   S  N N 104 
CYS OXT  O  N N 105 
CYS H    H  N N 106 
CYS H2   H  N N 107 
CYS HA   H  N N 108 
CYS HB2  H  N N 109 
CYS HB3  H  N N 110 
CYS HG   H  N N 111 
CYS HXT  H  N N 112 
GLN N    N  N N 113 
GLN CA   C  N S 114 
GLN C    C  N N 115 
GLN O    O  N N 116 
GLN CB   C  N N 117 
GLN CG   C  N N 118 
GLN CD   C  N N 119 
GLN OE1  O  N N 120 
GLN NE2  N  N N 121 
GLN OXT  O  N N 122 
GLN H    H  N N 123 
GLN H2   H  N N 124 
GLN HA   H  N N 125 
GLN HB2  H  N N 126 
GLN HB3  H  N N 127 
GLN HG2  H  N N 128 
GLN HG3  H  N N 129 
GLN HE21 H  N N 130 
GLN HE22 H  N N 131 
GLN HXT  H  N N 132 
GLU N    N  N N 133 
GLU CA   C  N S 134 
GLU C    C  N N 135 
GLU O    O  N N 136 
GLU CB   C  N N 137 
GLU CG   C  N N 138 
GLU CD   C  N N 139 
GLU OE1  O  N N 140 
GLU OE2  O  N N 141 
GLU OXT  O  N N 142 
GLU H    H  N N 143 
GLU H2   H  N N 144 
GLU HA   H  N N 145 
GLU HB2  H  N N 146 
GLU HB3  H  N N 147 
GLU HG2  H  N N 148 
GLU HG3  H  N N 149 
GLU HE2  H  N N 150 
GLU HXT  H  N N 151 
GLY N    N  N N 152 
GLY CA   C  N N 153 
GLY C    C  N N 154 
GLY O    O  N N 155 
GLY OXT  O  N N 156 
GLY H    H  N N 157 
GLY H2   H  N N 158 
GLY HA2  H  N N 159 
GLY HA3  H  N N 160 
GLY HXT  H  N N 161 
GOL C1   C  N N 162 
GOL O1   O  N N 163 
GOL C2   C  N N 164 
GOL O2   O  N N 165 
GOL C3   C  N N 166 
GOL O3   O  N N 167 
GOL H11  H  N N 168 
GOL H12  H  N N 169 
GOL HO1  H  N N 170 
GOL H2   H  N N 171 
GOL HO2  H  N N 172 
GOL H31  H  N N 173 
GOL H32  H  N N 174 
GOL HO3  H  N N 175 
HIS N    N  N N 176 
HIS CA   C  N S 177 
HIS C    C  N N 178 
HIS O    O  N N 179 
HIS CB   C  N N 180 
HIS CG   C  Y N 181 
HIS ND1  N  Y N 182 
HIS CD2  C  Y N 183 
HIS CE1  C  Y N 184 
HIS NE2  N  Y N 185 
HIS OXT  O  N N 186 
HIS H    H  N N 187 
HIS H2   H  N N 188 
HIS HA   H  N N 189 
HIS HB2  H  N N 190 
HIS HB3  H  N N 191 
HIS HD1  H  N N 192 
HIS HD2  H  N N 193 
HIS HE1  H  N N 194 
HIS HE2  H  N N 195 
HIS HXT  H  N N 196 
HOH O    O  N N 197 
HOH H1   H  N N 198 
HOH H2   H  N N 199 
ILE N    N  N N 200 
ILE CA   C  N S 201 
ILE C    C  N N 202 
ILE O    O  N N 203 
ILE CB   C  N S 204 
ILE CG1  C  N N 205 
ILE CG2  C  N N 206 
ILE CD1  C  N N 207 
ILE OXT  O  N N 208 
ILE H    H  N N 209 
ILE H2   H  N N 210 
ILE HA   H  N N 211 
ILE HB   H  N N 212 
ILE HG12 H  N N 213 
ILE HG13 H  N N 214 
ILE HG21 H  N N 215 
ILE HG22 H  N N 216 
ILE HG23 H  N N 217 
ILE HD11 H  N N 218 
ILE HD12 H  N N 219 
ILE HD13 H  N N 220 
ILE HXT  H  N N 221 
LEU N    N  N N 222 
LEU CA   C  N S 223 
LEU C    C  N N 224 
LEU O    O  N N 225 
LEU CB   C  N N 226 
LEU CG   C  N N 227 
LEU CD1  C  N N 228 
LEU CD2  C  N N 229 
LEU OXT  O  N N 230 
LEU H    H  N N 231 
LEU H2   H  N N 232 
LEU HA   H  N N 233 
LEU HB2  H  N N 234 
LEU HB3  H  N N 235 
LEU HG   H  N N 236 
LEU HD11 H  N N 237 
LEU HD12 H  N N 238 
LEU HD13 H  N N 239 
LEU HD21 H  N N 240 
LEU HD22 H  N N 241 
LEU HD23 H  N N 242 
LEU HXT  H  N N 243 
LYS N    N  N N 244 
LYS CA   C  N S 245 
LYS C    C  N N 246 
LYS O    O  N N 247 
LYS CB   C  N N 248 
LYS CG   C  N N 249 
LYS CD   C  N N 250 
LYS CE   C  N N 251 
LYS NZ   N  N N 252 
LYS OXT  O  N N 253 
LYS H    H  N N 254 
LYS H2   H  N N 255 
LYS HA   H  N N 256 
LYS HB2  H  N N 257 
LYS HB3  H  N N 258 
LYS HG2  H  N N 259 
LYS HG3  H  N N 260 
LYS HD2  H  N N 261 
LYS HD3  H  N N 262 
LYS HE2  H  N N 263 
LYS HE3  H  N N 264 
LYS HZ1  H  N N 265 
LYS HZ2  H  N N 266 
LYS HZ3  H  N N 267 
LYS HXT  H  N N 268 
MET N    N  N N 269 
MET CA   C  N S 270 
MET C    C  N N 271 
MET O    O  N N 272 
MET CB   C  N N 273 
MET CG   C  N N 274 
MET SD   S  N N 275 
MET CE   C  N N 276 
MET OXT  O  N N 277 
MET H    H  N N 278 
MET H2   H  N N 279 
MET HA   H  N N 280 
MET HB2  H  N N 281 
MET HB3  H  N N 282 
MET HG2  H  N N 283 
MET HG3  H  N N 284 
MET HE1  H  N N 285 
MET HE2  H  N N 286 
MET HE3  H  N N 287 
MET HXT  H  N N 288 
PHE N    N  N N 289 
PHE CA   C  N S 290 
PHE C    C  N N 291 
PHE O    O  N N 292 
PHE CB   C  N N 293 
PHE CG   C  Y N 294 
PHE CD1  C  Y N 295 
PHE CD2  C  Y N 296 
PHE CE1  C  Y N 297 
PHE CE2  C  Y N 298 
PHE CZ   C  Y N 299 
PHE OXT  O  N N 300 
PHE H    H  N N 301 
PHE H2   H  N N 302 
PHE HA   H  N N 303 
PHE HB2  H  N N 304 
PHE HB3  H  N N 305 
PHE HD1  H  N N 306 
PHE HD2  H  N N 307 
PHE HE1  H  N N 308 
PHE HE2  H  N N 309 
PHE HZ   H  N N 310 
PHE HXT  H  N N 311 
PRO N    N  N N 312 
PRO CA   C  N S 313 
PRO C    C  N N 314 
PRO O    O  N N 315 
PRO CB   C  N N 316 
PRO CG   C  N N 317 
PRO CD   C  N N 318 
PRO OXT  O  N N 319 
PRO H    H  N N 320 
PRO HA   H  N N 321 
PRO HB2  H  N N 322 
PRO HB3  H  N N 323 
PRO HG2  H  N N 324 
PRO HG3  H  N N 325 
PRO HD2  H  N N 326 
PRO HD3  H  N N 327 
PRO HXT  H  N N 328 
SER N    N  N N 329 
SER CA   C  N S 330 
SER C    C  N N 331 
SER O    O  N N 332 
SER CB   C  N N 333 
SER OG   O  N N 334 
SER OXT  O  N N 335 
SER H    H  N N 336 
SER H2   H  N N 337 
SER HA   H  N N 338 
SER HB2  H  N N 339 
SER HB3  H  N N 340 
SER HG   H  N N 341 
SER HXT  H  N N 342 
SIN C1   C  N N 343 
SIN O1   O  N N 344 
SIN O2   O  N N 345 
SIN C2   C  N N 346 
SIN C3   C  N N 347 
SIN C4   C  N N 348 
SIN O3   O  N N 349 
SIN O4   O  N N 350 
SIN HO2  H  N N 351 
SIN H21  H  N N 352 
SIN H22  H  N N 353 
SIN H31  H  N N 354 
SIN H32  H  N N 355 
SIN HO4  H  N N 356 
THR N    N  N N 357 
THR CA   C  N S 358 
THR C    C  N N 359 
THR O    O  N N 360 
THR CB   C  N R 361 
THR OG1  O  N N 362 
THR CG2  C  N N 363 
THR OXT  O  N N 364 
THR H    H  N N 365 
THR H2   H  N N 366 
THR HA   H  N N 367 
THR HB   H  N N 368 
THR HG1  H  N N 369 
THR HG21 H  N N 370 
THR HG22 H  N N 371 
THR HG23 H  N N 372 
THR HXT  H  N N 373 
TRP N    N  N N 374 
TRP CA   C  N S 375 
TRP C    C  N N 376 
TRP O    O  N N 377 
TRP CB   C  N N 378 
TRP CG   C  Y N 379 
TRP CD1  C  Y N 380 
TRP CD2  C  Y N 381 
TRP NE1  N  Y N 382 
TRP CE2  C  Y N 383 
TRP CE3  C  Y N 384 
TRP CZ2  C  Y N 385 
TRP CZ3  C  Y N 386 
TRP CH2  C  Y N 387 
TRP OXT  O  N N 388 
TRP H    H  N N 389 
TRP H2   H  N N 390 
TRP HA   H  N N 391 
TRP HB2  H  N N 392 
TRP HB3  H  N N 393 
TRP HD1  H  N N 394 
TRP HE1  H  N N 395 
TRP HE3  H  N N 396 
TRP HZ2  H  N N 397 
TRP HZ3  H  N N 398 
TRP HH2  H  N N 399 
TRP HXT  H  N N 400 
TYR N    N  N N 401 
TYR CA   C  N S 402 
TYR C    C  N N 403 
TYR O    O  N N 404 
TYR CB   C  N N 405 
TYR CG   C  Y N 406 
TYR CD1  C  Y N 407 
TYR CD2  C  Y N 408 
TYR CE1  C  Y N 409 
TYR CE2  C  Y N 410 
TYR CZ   C  Y N 411 
TYR OH   O  N N 412 
TYR OXT  O  N N 413 
TYR H    H  N N 414 
TYR H2   H  N N 415 
TYR HA   H  N N 416 
TYR HB2  H  N N 417 
TYR HB3  H  N N 418 
TYR HD1  H  N N 419 
TYR HD2  H  N N 420 
TYR HE1  H  N N 421 
TYR HE2  H  N N 422 
TYR HH   H  N N 423 
TYR HXT  H  N N 424 
VAL N    N  N N 425 
VAL CA   C  N S 426 
VAL C    C  N N 427 
VAL O    O  N N 428 
VAL CB   C  N N 429 
VAL CG1  C  N N 430 
VAL CG2  C  N N 431 
VAL OXT  O  N N 432 
VAL H    H  N N 433 
VAL H2   H  N N 434 
VAL HA   H  N N 435 
VAL HB   H  N N 436 
VAL HG11 H  N N 437 
VAL HG12 H  N N 438 
VAL HG13 H  N N 439 
VAL HG21 H  N N 440 
VAL HG22 H  N N 441 
VAL HG23 H  N N 442 
VAL HXT  H  N N 443 
VVO O1   O  N N 444 
VVO V1   V  N N 445 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
6HN N1  CE   sing N N 1   
6HN N1  O2   doub N N 2   
6HN N1  O1   sing N N 3   
6HN N   CA   sing N N 4   
6HN N   H    sing N N 5   
6HN N   HN2  sing N N 6   
6HN CA  C    sing N N 7   
6HN CA  CB   sing N N 8   
6HN CA  HA   sing N N 9   
6HN C   OXT  sing N N 10  
6HN C   O    doub N N 11  
6HN CB  CG   sing N N 12  
6HN CB  HB   sing N N 13  
6HN CB  HBA  sing N N 14  
6HN CG  CD   sing N N 15  
6HN CG  HG   sing N N 16  
6HN CG  HGA  sing N N 17  
6HN CD  CE   sing N N 18  
6HN CD  HD   sing N N 19  
6HN CD  HDA  sing N N 20  
6HN CE  HE   sing N N 21  
6HN CE  HEA  sing N N 22  
6HN OXT HXT  sing N N 23  
ALA N   CA   sing N N 24  
ALA N   H    sing N N 25  
ALA N   H2   sing N N 26  
ALA CA  C    sing N N 27  
ALA CA  CB   sing N N 28  
ALA CA  HA   sing N N 29  
ALA C   O    doub N N 30  
ALA C   OXT  sing N N 31  
ALA CB  HB1  sing N N 32  
ALA CB  HB2  sing N N 33  
ALA CB  HB3  sing N N 34  
ALA OXT HXT  sing N N 35  
ARG N   CA   sing N N 36  
ARG N   H    sing N N 37  
ARG N   H2   sing N N 38  
ARG CA  C    sing N N 39  
ARG CA  CB   sing N N 40  
ARG CA  HA   sing N N 41  
ARG C   O    doub N N 42  
ARG C   OXT  sing N N 43  
ARG CB  CG   sing N N 44  
ARG CB  HB2  sing N N 45  
ARG CB  HB3  sing N N 46  
ARG CG  CD   sing N N 47  
ARG CG  HG2  sing N N 48  
ARG CG  HG3  sing N N 49  
ARG CD  NE   sing N N 50  
ARG CD  HD2  sing N N 51  
ARG CD  HD3  sing N N 52  
ARG NE  CZ   sing N N 53  
ARG NE  HE   sing N N 54  
ARG CZ  NH1  sing N N 55  
ARG CZ  NH2  doub N N 56  
ARG NH1 HH11 sing N N 57  
ARG NH1 HH12 sing N N 58  
ARG NH2 HH21 sing N N 59  
ARG NH2 HH22 sing N N 60  
ARG OXT HXT  sing N N 61  
ASN N   CA   sing N N 62  
ASN N   H    sing N N 63  
ASN N   H2   sing N N 64  
ASN CA  C    sing N N 65  
ASN CA  CB   sing N N 66  
ASN CA  HA   sing N N 67  
ASN C   O    doub N N 68  
ASN C   OXT  sing N N 69  
ASN CB  CG   sing N N 70  
ASN CB  HB2  sing N N 71  
ASN CB  HB3  sing N N 72  
ASN CG  OD1  doub N N 73  
ASN CG  ND2  sing N N 74  
ASN ND2 HD21 sing N N 75  
ASN ND2 HD22 sing N N 76  
ASN OXT HXT  sing N N 77  
ASP N   CA   sing N N 78  
ASP N   H    sing N N 79  
ASP N   H2   sing N N 80  
ASP CA  C    sing N N 81  
ASP CA  CB   sing N N 82  
ASP CA  HA   sing N N 83  
ASP C   O    doub N N 84  
ASP C   OXT  sing N N 85  
ASP CB  CG   sing N N 86  
ASP CB  HB2  sing N N 87  
ASP CB  HB3  sing N N 88  
ASP CG  OD1  doub N N 89  
ASP CG  OD2  sing N N 90  
ASP OD2 HD2  sing N N 91  
ASP OXT HXT  sing N N 92  
CYS N   CA   sing N N 93  
CYS N   H    sing N N 94  
CYS N   H2   sing N N 95  
CYS CA  C    sing N N 96  
CYS CA  CB   sing N N 97  
CYS CA  HA   sing N N 98  
CYS C   O    doub N N 99  
CYS C   OXT  sing N N 100 
CYS CB  SG   sing N N 101 
CYS CB  HB2  sing N N 102 
CYS CB  HB3  sing N N 103 
CYS SG  HG   sing N N 104 
CYS OXT HXT  sing N N 105 
GLN N   CA   sing N N 106 
GLN N   H    sing N N 107 
GLN N   H2   sing N N 108 
GLN CA  C    sing N N 109 
GLN CA  CB   sing N N 110 
GLN CA  HA   sing N N 111 
GLN C   O    doub N N 112 
GLN C   OXT  sing N N 113 
GLN CB  CG   sing N N 114 
GLN CB  HB2  sing N N 115 
GLN CB  HB3  sing N N 116 
GLN CG  CD   sing N N 117 
GLN CG  HG2  sing N N 118 
GLN CG  HG3  sing N N 119 
GLN CD  OE1  doub N N 120 
GLN CD  NE2  sing N N 121 
GLN NE2 HE21 sing N N 122 
GLN NE2 HE22 sing N N 123 
GLN OXT HXT  sing N N 124 
GLU N   CA   sing N N 125 
GLU N   H    sing N N 126 
GLU N   H2   sing N N 127 
GLU CA  C    sing N N 128 
GLU CA  CB   sing N N 129 
GLU CA  HA   sing N N 130 
GLU C   O    doub N N 131 
GLU C   OXT  sing N N 132 
GLU CB  CG   sing N N 133 
GLU CB  HB2  sing N N 134 
GLU CB  HB3  sing N N 135 
GLU CG  CD   sing N N 136 
GLU CG  HG2  sing N N 137 
GLU CG  HG3  sing N N 138 
GLU CD  OE1  doub N N 139 
GLU CD  OE2  sing N N 140 
GLU OE2 HE2  sing N N 141 
GLU OXT HXT  sing N N 142 
GLY N   CA   sing N N 143 
GLY N   H    sing N N 144 
GLY N   H2   sing N N 145 
GLY CA  C    sing N N 146 
GLY CA  HA2  sing N N 147 
GLY CA  HA3  sing N N 148 
GLY C   O    doub N N 149 
GLY C   OXT  sing N N 150 
GLY OXT HXT  sing N N 151 
GOL C1  O1   sing N N 152 
GOL C1  C2   sing N N 153 
GOL C1  H11  sing N N 154 
GOL C1  H12  sing N N 155 
GOL O1  HO1  sing N N 156 
GOL C2  O2   sing N N 157 
GOL C2  C3   sing N N 158 
GOL C2  H2   sing N N 159 
GOL O2  HO2  sing N N 160 
GOL C3  O3   sing N N 161 
GOL C3  H31  sing N N 162 
GOL C3  H32  sing N N 163 
GOL O3  HO3  sing N N 164 
HIS N   CA   sing N N 165 
HIS N   H    sing N N 166 
HIS N   H2   sing N N 167 
HIS CA  C    sing N N 168 
HIS CA  CB   sing N N 169 
HIS CA  HA   sing N N 170 
HIS C   O    doub N N 171 
HIS C   OXT  sing N N 172 
HIS CB  CG   sing N N 173 
HIS CB  HB2  sing N N 174 
HIS CB  HB3  sing N N 175 
HIS CG  ND1  sing Y N 176 
HIS CG  CD2  doub Y N 177 
HIS ND1 CE1  doub Y N 178 
HIS ND1 HD1  sing N N 179 
HIS CD2 NE2  sing Y N 180 
HIS CD2 HD2  sing N N 181 
HIS CE1 NE2  sing Y N 182 
HIS CE1 HE1  sing N N 183 
HIS NE2 HE2  sing N N 184 
HIS OXT HXT  sing N N 185 
HOH O   H1   sing N N 186 
HOH O   H2   sing N N 187 
ILE N   CA   sing N N 188 
ILE N   H    sing N N 189 
ILE N   H2   sing N N 190 
ILE CA  C    sing N N 191 
ILE CA  CB   sing N N 192 
ILE CA  HA   sing N N 193 
ILE C   O    doub N N 194 
ILE C   OXT  sing N N 195 
ILE CB  CG1  sing N N 196 
ILE CB  CG2  sing N N 197 
ILE CB  HB   sing N N 198 
ILE CG1 CD1  sing N N 199 
ILE CG1 HG12 sing N N 200 
ILE CG1 HG13 sing N N 201 
ILE CG2 HG21 sing N N 202 
ILE CG2 HG22 sing N N 203 
ILE CG2 HG23 sing N N 204 
ILE CD1 HD11 sing N N 205 
ILE CD1 HD12 sing N N 206 
ILE CD1 HD13 sing N N 207 
ILE OXT HXT  sing N N 208 
LEU N   CA   sing N N 209 
LEU N   H    sing N N 210 
LEU N   H2   sing N N 211 
LEU CA  C    sing N N 212 
LEU CA  CB   sing N N 213 
LEU CA  HA   sing N N 214 
LEU C   O    doub N N 215 
LEU C   OXT  sing N N 216 
LEU CB  CG   sing N N 217 
LEU CB  HB2  sing N N 218 
LEU CB  HB3  sing N N 219 
LEU CG  CD1  sing N N 220 
LEU CG  CD2  sing N N 221 
LEU CG  HG   sing N N 222 
LEU CD1 HD11 sing N N 223 
LEU CD1 HD12 sing N N 224 
LEU CD1 HD13 sing N N 225 
LEU CD2 HD21 sing N N 226 
LEU CD2 HD22 sing N N 227 
LEU CD2 HD23 sing N N 228 
LEU OXT HXT  sing N N 229 
LYS N   CA   sing N N 230 
LYS N   H    sing N N 231 
LYS N   H2   sing N N 232 
LYS CA  C    sing N N 233 
LYS CA  CB   sing N N 234 
LYS CA  HA   sing N N 235 
LYS C   O    doub N N 236 
LYS C   OXT  sing N N 237 
LYS CB  CG   sing N N 238 
LYS CB  HB2  sing N N 239 
LYS CB  HB3  sing N N 240 
LYS CG  CD   sing N N 241 
LYS CG  HG2  sing N N 242 
LYS CG  HG3  sing N N 243 
LYS CD  CE   sing N N 244 
LYS CD  HD2  sing N N 245 
LYS CD  HD3  sing N N 246 
LYS CE  NZ   sing N N 247 
LYS CE  HE2  sing N N 248 
LYS CE  HE3  sing N N 249 
LYS NZ  HZ1  sing N N 250 
LYS NZ  HZ2  sing N N 251 
LYS NZ  HZ3  sing N N 252 
LYS OXT HXT  sing N N 253 
MET N   CA   sing N N 254 
MET N   H    sing N N 255 
MET N   H2   sing N N 256 
MET CA  C    sing N N 257 
MET CA  CB   sing N N 258 
MET CA  HA   sing N N 259 
MET C   O    doub N N 260 
MET C   OXT  sing N N 261 
MET CB  CG   sing N N 262 
MET CB  HB2  sing N N 263 
MET CB  HB3  sing N N 264 
MET CG  SD   sing N N 265 
MET CG  HG2  sing N N 266 
MET CG  HG3  sing N N 267 
MET SD  CE   sing N N 268 
MET CE  HE1  sing N N 269 
MET CE  HE2  sing N N 270 
MET CE  HE3  sing N N 271 
MET OXT HXT  sing N N 272 
PHE N   CA   sing N N 273 
PHE N   H    sing N N 274 
PHE N   H2   sing N N 275 
PHE CA  C    sing N N 276 
PHE CA  CB   sing N N 277 
PHE CA  HA   sing N N 278 
PHE C   O    doub N N 279 
PHE C   OXT  sing N N 280 
PHE CB  CG   sing N N 281 
PHE CB  HB2  sing N N 282 
PHE CB  HB3  sing N N 283 
PHE CG  CD1  doub Y N 284 
PHE CG  CD2  sing Y N 285 
PHE CD1 CE1  sing Y N 286 
PHE CD1 HD1  sing N N 287 
PHE CD2 CE2  doub Y N 288 
PHE CD2 HD2  sing N N 289 
PHE CE1 CZ   doub Y N 290 
PHE CE1 HE1  sing N N 291 
PHE CE2 CZ   sing Y N 292 
PHE CE2 HE2  sing N N 293 
PHE CZ  HZ   sing N N 294 
PHE OXT HXT  sing N N 295 
PRO N   CA   sing N N 296 
PRO N   CD   sing N N 297 
PRO N   H    sing N N 298 
PRO CA  C    sing N N 299 
PRO CA  CB   sing N N 300 
PRO CA  HA   sing N N 301 
PRO C   O    doub N N 302 
PRO C   OXT  sing N N 303 
PRO CB  CG   sing N N 304 
PRO CB  HB2  sing N N 305 
PRO CB  HB3  sing N N 306 
PRO CG  CD   sing N N 307 
PRO CG  HG2  sing N N 308 
PRO CG  HG3  sing N N 309 
PRO CD  HD2  sing N N 310 
PRO CD  HD3  sing N N 311 
PRO OXT HXT  sing N N 312 
SER N   CA   sing N N 313 
SER N   H    sing N N 314 
SER N   H2   sing N N 315 
SER CA  C    sing N N 316 
SER CA  CB   sing N N 317 
SER CA  HA   sing N N 318 
SER C   O    doub N N 319 
SER C   OXT  sing N N 320 
SER CB  OG   sing N N 321 
SER CB  HB2  sing N N 322 
SER CB  HB3  sing N N 323 
SER OG  HG   sing N N 324 
SER OXT HXT  sing N N 325 
SIN C1  O1   doub N N 326 
SIN C1  O2   sing N N 327 
SIN C1  C2   sing N N 328 
SIN O2  HO2  sing N N 329 
SIN C2  C3   sing N N 330 
SIN C2  H21  sing N N 331 
SIN C2  H22  sing N N 332 
SIN C3  C4   sing N N 333 
SIN C3  H31  sing N N 334 
SIN C3  H32  sing N N 335 
SIN C4  O3   doub N N 336 
SIN C4  O4   sing N N 337 
SIN O4  HO4  sing N N 338 
THR N   CA   sing N N 339 
THR N   H    sing N N 340 
THR N   H2   sing N N 341 
THR CA  C    sing N N 342 
THR CA  CB   sing N N 343 
THR CA  HA   sing N N 344 
THR C   O    doub N N 345 
THR C   OXT  sing N N 346 
THR CB  OG1  sing N N 347 
THR CB  CG2  sing N N 348 
THR CB  HB   sing N N 349 
THR OG1 HG1  sing N N 350 
THR CG2 HG21 sing N N 351 
THR CG2 HG22 sing N N 352 
THR CG2 HG23 sing N N 353 
THR OXT HXT  sing N N 354 
TRP N   CA   sing N N 355 
TRP N   H    sing N N 356 
TRP N   H2   sing N N 357 
TRP CA  C    sing N N 358 
TRP CA  CB   sing N N 359 
TRP CA  HA   sing N N 360 
TRP C   O    doub N N 361 
TRP C   OXT  sing N N 362 
TRP CB  CG   sing N N 363 
TRP CB  HB2  sing N N 364 
TRP CB  HB3  sing N N 365 
TRP CG  CD1  doub Y N 366 
TRP CG  CD2  sing Y N 367 
TRP CD1 NE1  sing Y N 368 
TRP CD1 HD1  sing N N 369 
TRP CD2 CE2  doub Y N 370 
TRP CD2 CE3  sing Y N 371 
TRP NE1 CE2  sing Y N 372 
TRP NE1 HE1  sing N N 373 
TRP CE2 CZ2  sing Y N 374 
TRP CE3 CZ3  doub Y N 375 
TRP CE3 HE3  sing N N 376 
TRP CZ2 CH2  doub Y N 377 
TRP CZ2 HZ2  sing N N 378 
TRP CZ3 CH2  sing Y N 379 
TRP CZ3 HZ3  sing N N 380 
TRP CH2 HH2  sing N N 381 
TRP OXT HXT  sing N N 382 
TYR N   CA   sing N N 383 
TYR N   H    sing N N 384 
TYR N   H2   sing N N 385 
TYR CA  C    sing N N 386 
TYR CA  CB   sing N N 387 
TYR CA  HA   sing N N 388 
TYR C   O    doub N N 389 
TYR C   OXT  sing N N 390 
TYR CB  CG   sing N N 391 
TYR CB  HB2  sing N N 392 
TYR CB  HB3  sing N N 393 
TYR CG  CD1  doub Y N 394 
TYR CG  CD2  sing Y N 395 
TYR CD1 CE1  sing Y N 396 
TYR CD1 HD1  sing N N 397 
TYR CD2 CE2  doub Y N 398 
TYR CD2 HD2  sing N N 399 
TYR CE1 CZ   doub Y N 400 
TYR CE1 HE1  sing N N 401 
TYR CE2 CZ   sing Y N 402 
TYR CE2 HE2  sing N N 403 
TYR CZ  OH   sing N N 404 
TYR OH  HH   sing N N 405 
TYR OXT HXT  sing N N 406 
VAL N   CA   sing N N 407 
VAL N   H    sing N N 408 
VAL N   H2   sing N N 409 
VAL CA  C    sing N N 410 
VAL CA  CB   sing N N 411 
VAL CA  HA   sing N N 412 
VAL C   O    doub N N 413 
VAL C   OXT  sing N N 414 
VAL CB  CG1  sing N N 415 
VAL CB  CG2  sing N N 416 
VAL CB  HB   sing N N 417 
VAL CG1 HG11 sing N N 418 
VAL CG1 HG12 sing N N 419 
VAL CG1 HG13 sing N N 420 
VAL CG2 HG21 sing N N 421 
VAL CG2 HG22 sing N N 422 
VAL CG2 HG23 sing N N 423 
VAL OXT HXT  sing N N 424 
VVO V1  O1   doub N N 425 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   9DQ0 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.crystal_system   orthorhombic 
_space_group.IT_number        19 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DQ2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013313 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012685 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010292 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
BR ? ? 25.79822 9.11301 ? ? 1.35700  25.34896 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
V  ? ? 18.66134 4.26681 ? ? 3.12589  55.31642 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . PRO A 1 2   ? -1.27646  11.54705  17.98039  1.000 44.92519 ? 2   PRO A N   1 
ATOM   2    C  CA  . PRO A 1 2   ? -1.55049  11.61726  16.54044  1.000 38.13034 ? 2   PRO A CA  1 
ATOM   3    C  C   . PRO A 1 2   ? -0.27907  11.61784  15.70908  1.000 31.77048 ? 2   PRO A C   1 
ATOM   4    O  O   . PRO A 1 2   ? 0.80143   11.37713  16.25113  1.000 36.69481 ? 2   PRO A O   1 
ATOM   5    C  CB  . PRO A 1 2   ? -2.29238  12.94261  16.38901  1.000 44.11802 ? 2   PRO A CB  1 
ATOM   6    C  CG  . PRO A 1 2   ? -2.90517  13.17022  17.73519  1.000 49.73439 ? 2   PRO A CG  1 
ATOM   7    C  CD  . PRO A 1 2   ? -1.89574  12.66107  18.71460  1.000 44.96963 ? 2   PRO A CD  1 
ATOM   8    N  N   . LEU A 1 3   ? -0.43079  11.86162  14.40940  1.000 26.05387 ? 3   LEU A N   1 
ATOM   9    C  CA  . LEU A 1 3   ? 0.67242   11.80928  13.45792  1.000 23.42938 ? 3   LEU A CA  1 
ATOM   10   C  C   . LEU A 1 3   ? 1.58496   13.02421  13.57506  1.000 33.77057 ? 3   LEU A C   1 
ATOM   11   O  O   . LEU A 1 3   ? 1.15725   14.11303  13.96021  1.000 27.16679 ? 3   LEU A O   1 
ATOM   12   C  CB  . LEU A 1 3   ? 0.13588   11.75894  12.02976  1.000 20.48054 ? 3   LEU A CB  1 
ATOM   13   C  CG  . LEU A 1 3   ? -0.53713  10.45682  11.62047  1.000 16.41159 ? 3   LEU A CG  1 
ATOM   14   C  CD1 . LEU A 1 3   ? -0.91931  10.50825  10.16932  1.000 22.66654 ? 3   LEU A CD1 1 
ATOM   15   C  CD2 . LEU A 1 3   ? 0.43159   9.31834   11.88253  1.000 22.44852 ? 3   LEU A CD2 1 
ATOM   16   N  N   . GLY A 1 4   ? 2.85039   12.83455  13.17151  1.000 23.77088 ? 4   GLY A N   1 
ATOM   17   C  CA  . GLY A 1 4   ? 3.77726   13.93896  13.02374  1.000 27.85502 ? 4   GLY A CA  1 
ATOM   18   C  C   . GLY A 1 4   ? 3.20934   15.13134  12.26712  1.000 33.62618 ? 4   GLY A C   1 
ATOM   19   O  O   . GLY A 1 4   ? 2.20089   15.01393  11.55605  1.000 27.79411 ? 4   GLY A O   1 
ATOM   20   N  N   . THR A 1 5   ? 3.85535   16.29320  12.41948  1.000 34.69320 ? 5   THR A N   1 
ATOM   21   C  CA  . THR A 1 5   ? 3.35808   17.52047  11.81299  1.000 34.24692 ? 5   THR A CA  1 
ATOM   22   C  C   . THR A 1 5   ? 3.41591   17.47186  10.29527  1.000 28.22222 ? 5   THR A C   1 
ATOM   23   O  O   . THR A 1 5   ? 2.70791   18.23402  9.63195   1.000 29.99722 ? 5   THR A O   1 
ATOM   24   C  CB  . THR A 1 5   ? 4.16747   18.71429  12.32412  1.000 45.37564 ? 5   THR A CB  1 
ATOM   25   O  OG1 . THR A 1 5   ? 5.41046   18.78295  11.61197  1.000 42.52143 ? 5   THR A OG1 1 
ATOM   26   C  CG2 . THR A 1 5   ? 4.45470   18.54840  13.81921  1.000 35.00819 ? 5   THR A CG2 1 
ATOM   27   N  N   . GLU A 1 6   ? 4.23863   16.60197  9.72724   1.000 23.54119 ? 6   GLU A N   1 
ATOM   28   C  CA  . GLU A 1 6   ? 4.27466   16.45091  8.28749   1.000 22.58654 ? 6   GLU A CA  1 
ATOM   29   C  C   . GLU A 1 6   ? 3.34418   15.35793  7.79074   1.000 16.85611 ? 6   GLU A C   1 
ATOM   30   O  O   . GLU A 1 6   ? 3.42998   14.98714  6.61748   1.000 21.72901 ? 6   GLU A O   1 
ATOM   31   C  CB  . GLU A 1 6   ? 5.69515   16.15364  7.81722   1.000 27.72403 ? 6   GLU A CB  1 
ATOM   32   C  CG  . GLU A 1 6   ? 6.67278   17.23503  8.20077   1.000 41.83146 ? 6   GLU A CG  1 
ATOM   33   C  CD  . GLU A 1 6   ? 7.89313   17.24586  7.31794   1.000 51.19620 ? 6   GLU A CD  1 
ATOM   34   O  OE1 . GLU A 1 6   ? 8.64295   16.25421  7.36471   1.000 49.15462 ? 6   GLU A OE1 1 
ATOM   35   O  OE2 . GLU A 1 6   ? 8.09254   18.22534  6.56144   1.000 62.90197 ? 6   GLU A OE2 1 
ATOM   36   N  N   . GLY A 1 7   ? 2.47317   14.83190  8.64720   1.000 16.39194 ? 7   GLY A N   1 
ATOM   37   C  CA  . GLY A 1 7   ? 1.44245   13.92379  8.18591   1.000 16.82867 ? 7   GLY A CA  1 
ATOM   38   C  C   . GLY A 1 7   ? 1.82225   12.46748  8.15086   1.000 10.77744 ? 7   GLY A C   1 
ATOM   39   O  O   . GLY A 1 7   ? 1.10064   11.67248  7.52718   1.000 12.15603 ? 7   GLY A O   1 
ATOM   40   N  N   . PHE A 1 8   ? 2.92849   12.08853  8.77501   1.000 11.76995 ? 8   PHE A N   1 
ATOM   41   C  CA  . PHE A 1 8   ? 3.32222   10.68814  8.84546   1.000 10.55043 ? 8   PHE A CA  1 
ATOM   42   C  C   . PHE A 1 8   ? 4.13960   10.45941  10.10285  1.000 13.68042 ? 8   PHE A C   1 
ATOM   43   O  O   . PHE A 1 8   ? 4.67677   11.40255  10.71288  1.000 12.67922 ? 8   PHE A O   1 
ATOM   44   C  CB  . PHE A 1 8   ? 4.13369   10.26013  7.61620   1.000 10.67311 ? 8   PHE A CB  1 
ATOM   45   C  CG  . PHE A 1 8   ? 5.55284   10.76750  7.63480   1.000 11.37103 ? 8   PHE A CG  1 
ATOM   46   C  CD1 . PHE A 1 8   ? 5.82705   12.07484  7.27069   1.000 15.18895 ? 8   PHE A CD1 1 
ATOM   47   C  CD2 . PHE A 1 8   ? 6.60373   9.94039   8.01034   1.000 15.73395 ? 8   PHE A CD2 1 
ATOM   48   C  CE1 . PHE A 1 8   ? 7.15466   12.55779  7.27415   1.000 15.13494 ? 8   PHE A CE1 1 
ATOM   49   C  CE2 . PHE A 1 8   ? 7.92961   10.41066  8.01480   1.000 20.82365 ? 8   PHE A CE2 1 
ATOM   50   C  CZ  . PHE A 1 8   ? 8.19966   11.72242  7.64983   1.000 17.62427 ? 8   PHE A CZ  1 
ATOM   51   N  N   . THR A 1 9   ? 4.24191   9.18365   10.46339  1.000 10.44178 ? 9   THR A N   1 
ATOM   52   C  CA  A THR A 1 9   ? 5.06205   8.69874   11.57246  0.640 11.71402 ? 9   THR A CA  1 
ATOM   53   C  CA  B THR A 1 9   ? 5.19110   8.76141   11.47482  0.360 11.79662 ? 9   THR A CA  1 
ATOM   54   C  C   . THR A 1 9   ? 5.60682   7.32050   11.21467  1.000 13.22659 ? 9   THR A C   1 
ATOM   55   O  O   . THR A 1 9   ? 4.85048   6.49576   10.70369  1.000 13.37830 ? 9   THR A O   1 
ATOM   56   C  CB  A THR A 1 9   ? 4.22990   8.59409   12.86648  0.640 14.03258 ? 9   THR A CB  1 
ATOM   57   C  CB  B THR A 1 9   ? 4.63025   8.90853   12.89342  0.360 14.58151 ? 9   THR A CB  1 
ATOM   58   O  OG1 A THR A 1 9   ? 3.79838   9.89074   13.27174  0.640 16.64471 ? 9   THR A OG1 1 
ATOM   59   O  OG1 B THR A 1 9   ? 5.66689   8.62315   13.84499  0.360 17.12556 ? 9   THR A OG1 1 
ATOM   60   C  CG2 A THR A 1 9   ? 5.02648   7.98982   14.00527  0.640 17.27481 ? 9   THR A CG2 1 
ATOM   61   C  CG2 B THR A 1 9   ? 3.49328   7.94941   13.09961  0.360 13.73014 ? 9   THR A CG2 1 
ATOM   62   N  N   . VAL A 1 10  ? 6.86404   7.04527   11.52755  1.000 10.48752 ? 10  VAL A N   1 
ATOM   63   C  CA  . VAL A 1 10  ? 7.43202   5.72168   11.38966  1.000 10.94852 ? 10  VAL A CA  1 
ATOM   64   C  C   . VAL A 1 10  ? 7.54574   5.13577   12.78868  1.000 14.61603 ? 10  VAL A C   1 
ATOM   65   O  O   . VAL A 1 10  ? 8.04912   5.80183   13.70597  1.000 14.82712 ? 10  VAL A O   1 
ATOM   66   C  CB  . VAL A 1 10  ? 8.78755   5.76346   10.67999  1.000 11.01912 ? 10  VAL A CB  1 
ATOM   67   C  CG1 . VAL A 1 10  ? 9.37927   4.33948   10.62126  1.000 14.18336 ? 10  VAL A CG1 1 
ATOM   68   C  CG2 . VAL A 1 10  ? 8.59382   6.33283   9.26204   1.000 13.03949 ? 10  VAL A CG2 1 
ATOM   69   N  N   . ILE A 1 11  ? 7.09481   3.89419   12.94987  1.000 11.35465 ? 11  ILE A N   1 
ATOM   70   C  CA  . ILE A 1 11  ? 7.12445   3.24625   14.25945  1.000 13.26062 ? 11  ILE A CA  1 
ATOM   71   C  C   . ILE A 1 11  ? 7.80443   1.88280   14.16806  1.000 16.33302 ? 11  ILE A C   1 
ATOM   72   O  O   . ILE A 1 11  ? 7.90596   1.26382   13.10210  1.000 14.55642 ? 11  ILE A O   1 
ATOM   73   C  CB  . ILE A 1 11  ? 5.71660   3.08615   14.85951  1.000 13.65844 ? 11  ILE A CB  1 
ATOM   74   C  CG1 . ILE A 1 11  ? 4.81596   2.23562   13.94509  1.000 15.79381 ? 11  ILE A CG1 1 
ATOM   75   C  CG2 . ILE A 1 11  ? 5.07297   4.43751   15.09164  1.000 17.33168 ? 11  ILE A CG2 1 
ATOM   76   C  CD1 . ILE A 1 11  ? 3.59034   1.69287   14.66936  1.000 17.82523 ? 11  ILE A CD1 1 
ATOM   77   N  N   . ASP A 1 12  ? 8.31650   1.42765   15.32071  1.000 17.37235 ? 12  ASP A N   1 
ATOM   78   C  CA  . ASP A 1 12  ? 8.77634   0.05781   15.46360  1.000 19.23158 ? 12  ASP A CA  1 
ATOM   79   C  C   . ASP A 1 12  ? 7.60335   -0.83222  15.85416  1.000 20.32702 ? 12  ASP A C   1 
ATOM   80   O  O   . ASP A 1 12  ? 6.70472   -0.40959  16.59011  1.000 24.48088 ? 12  ASP A O   1 
ATOM   81   C  CB  . ASP A 1 12  ? 9.87682   -0.04022  16.51893  1.000 27.95548 ? 12  ASP A CB  1 
ATOM   82   C  CG  . ASP A 1 12  ? 11.11369  0.73988   16.14284  1.000 38.03780 ? 12  ASP A CG  1 
ATOM   83   O  OD1 . ASP A 1 12  ? 11.55461  0.66421   14.96313  1.000 30.10363 ? 12  ASP A OD1 1 
ATOM   84   O  OD2 . ASP A 1 12  ? 11.64897  1.42605   17.04468  1.000 43.17267 ? 12  ASP A OD2 1 
ATOM   85   N  N   . LEU A 1 13  ? 7.61382   -2.07755  15.35473  1.000 19.12044 ? 13  LEU A N   1 
ATOM   86   C  CA  . LEU A 1 13  ? 6.51297   -2.97372  15.65106  1.000 21.04980 ? 13  LEU A CA  1 
ATOM   87   C  C   . LEU A 1 13  ? 6.89101   -3.96196  16.74608  1.000 23.00788 ? 13  LEU A C   1 
ATOM   88   O  O   . LEU A 1 13  ? 8.06105   -4.32235  16.88389  1.000 25.99576 ? 13  LEU A O   1 
ATOM   89   C  CB  . LEU A 1 13  ? 6.12169   -3.76872  14.40225  1.000 19.41415 ? 13  LEU A CB  1 
ATOM   90   C  CG  . LEU A 1 13  ? 5.58607   -2.91962  13.26239  1.000 23.67626 ? 13  LEU A CG  1 
ATOM   91   C  CD1 . LEU A 1 13  ? 5.52103   -3.77779  12.01856  1.000 21.77562 ? 13  LEU A CD1 1 
ATOM   92   C  CD2 . LEU A 1 13  ? 4.21439   -2.36465  13.66509  1.000 24.23904 ? 13  LEU A CD2 1 
ATOM   93   N  N   . PRO A 1 14  ? 5.89892   -4.43990  17.49732  1.000 26.99507 ? 14  PRO A N   1 
ATOM   94   C  CA  . PRO A 1 14  ? 6.16310   -5.48935  18.48419  1.000 39.92251 ? 14  PRO A CA  1 
ATOM   95   C  C   . PRO A 1 14  ? 6.50692   -6.79958  17.79719  1.000 33.08680 ? 14  PRO A C   1 
ATOM   96   O  O   . PRO A 1 14  ? 6.36242   -6.95931  16.58427  1.000 27.51227 ? 14  PRO A O   1 
ATOM   97   C  CB  . PRO A 1 14  ? 4.84795   -5.59221  19.25774  1.000 38.31311 ? 14  PRO A CB  1 
ATOM   98   C  CG  . PRO A 1 14  ? 3.80541   -5.09556  18.30150  1.000 38.64333 ? 14  PRO A CG  1 
ATOM   99   C  CD  . PRO A 1 14  ? 4.48531   -4.02552  17.48423  1.000 34.34218 ? 14  PRO A CD  1 
ATOM   100  N  N   . GLU A 1 15  ? 6.99484   -7.74236  18.60234  1.000 30.90937 ? 15  GLU A N   1 
ATOM   101  C  CA  . GLU A 1 15  ? 7.13260   -9.11917  18.15568  1.000 35.51601 ? 15  GLU A CA  1 
ATOM   102  C  C   . GLU A 1 15  ? 5.76891   -9.64412  17.73340  1.000 24.96830 ? 15  GLU A C   1 
ATOM   103  O  O   . GLU A 1 15  ? 4.74819   -9.31609  18.34473  1.000 29.35724 ? 15  GLU A O   1 
ATOM   104  C  CB  . GLU A 1 15  ? 7.70542   -9.97901  19.28465  1.000 47.07115 ? 15  GLU A CB  1 
ATOM   105  C  CG  . GLU A 1 15  ? 8.84613   -10.90282 18.87616  1.000 56.55257 ? 15  GLU A CG  1 
ATOM   106  C  CD  . GLU A 1 15  ? 9.33826   -11.77544 20.02693  1.000 63.80419 ? 15  GLU A CD  1 
ATOM   107  O  OE1 . GLU A 1 15  ? 9.78663   -11.21884 21.05856  1.000 53.65961 ? 15  GLU A OE1 1 
ATOM   108  O  OE2 . GLU A 1 15  ? 9.26508   -13.01875 19.89912  1.000 59.04953 ? 15  GLU A OE2 1 
ATOM   109  N  N   . VAL A 1 16  ? 5.73977   -10.42178 16.65844  1.000 28.12880 ? 16  VAL A N   1 
ATOM   110  C  CA  . VAL A 1 16  ? 4.47768   -10.93913 16.14663  1.000 30.38325 ? 16  VAL A CA  1 
ATOM   111  C  C   . VAL A 1 16  ? 4.38267   -12.43612 16.42090  1.000 25.66279 ? 16  VAL A C   1 
ATOM   112  O  O   . VAL A 1 16  ? 5.38139   -13.12960 16.64392  1.000 30.48292 ? 16  VAL A O   1 
ATOM   113  C  CB  . VAL A 1 16  ? 4.27827   -10.63712 14.64291  1.000 28.80117 ? 16  VAL A CB  1 
ATOM   114  C  CG1 . VAL A 1 16  ? 4.31681   -9.12261  14.38516  1.000 28.24014 ? 16  VAL A CG1 1 
ATOM   115  C  CG2 . VAL A 1 16  ? 5.29865   -11.38619 13.76960  1.000 26.28666 ? 16  VAL A CG2 1 
ATOM   116  N  N   . ALA A 1 17  ? 3.14734   -12.92624 16.41694  1.000 24.54811 ? 17  ALA A N   1 
ATOM   117  C  CA  . ALA A 1 17  ? 2.87532   -14.33490 16.65546  1.000 26.57268 ? 17  ALA A CA  1 
ATOM   118  C  C   . ALA A 1 17  ? 3.64804   -15.21443 15.67385  1.000 26.84889 ? 17  ALA A C   1 
ATOM   119  O  O   . ALA A 1 17  ? 3.88278   -14.82968 14.52227  1.000 24.27625 ? 17  ALA A O   1 
ATOM   120  C  CB  . ALA A 1 17  ? 1.38173   -14.60755 16.52391  1.000 25.72516 ? 17  ALA A CB  1 
ATOM   121  N  N   . PRO A 1 18  ? 4.05675   -16.40991 16.09604  1.000 27.90917 ? 18  PRO A N   1 
ATOM   122  C  CA  . PRO A 1 18  ? 4.88368   -17.25496 15.21857  1.000 27.29899 ? 18  PRO A CA  1 
ATOM   123  C  C   . PRO A 1 18  ? 4.19768   -17.72126 13.93261  1.000 20.17965 ? 18  PRO A C   1 
ATOM   124  O  O   . PRO A 1 18  ? 4.91053   -18.13545 13.01010  1.000 25.87610 ? 18  PRO A O   1 
ATOM   125  C  CB  . PRO A 1 18  ? 5.24169   -18.44721 16.11519  1.000 30.80358 ? 18  PRO A CB  1 
ATOM   126  C  CG  . PRO A 1 18  ? 4.25888   -18.39028 17.25072  1.000 31.59586 ? 18  PRO A CG  1 
ATOM   127  C  CD  . PRO A 1 18  ? 3.98640   -16.94168 17.46847  1.000 25.13275 ? 18  PRO A CD  1 
ATOM   128  N  N   . ASP A 1 19  ? 2.86600   -17.67052 13.82360  1.000 24.15213 ? 19  ASP A N   1 
ATOM   129  C  CA  . ASP A 1 19  ? 2.22831   -18.14570 12.59868  1.000 19.45750 ? 19  ASP A CA  1 
ATOM   130  C  C   . ASP A 1 19  ? 2.20077   -17.09220 11.49496  1.000 21.15293 ? 19  ASP A C   1 
ATOM   131  O  O   . ASP A 1 19  ? 1.89038   -17.43230 10.34328  1.000 18.83496 ? 19  ASP A O   1 
ATOM   132  C  CB  . ASP A 1 19  ? 0.80430   -18.64047 12.87498  1.000 24.69546 ? 19  ASP A CB  1 
ATOM   133  C  CG  . ASP A 1 19  ? -0.12270  -17.55373 13.40861  1.000 25.64858 ? 19  ASP A CG  1 
ATOM   134  O  OD1 . ASP A 1 19  ? 0.31872   -16.40411 13.61425  1.000 31.59842 ? 19  ASP A OD1 1 
ATOM   135  O  OD2 . ASP A 1 19  ? -1.31602  -17.86293 13.62849  1.000 36.69256 ? 19  ASP A OD2 1 
ATOM   136  N  N   . ILE A 1 20  ? 2.55723   -15.84693 11.80110  1.000 19.63882 ? 20  ILE A N   1 
ATOM   137  C  CA  . ILE A 1 20  ? 2.38211   -14.77068 10.82342  1.000 19.34154 ? 20  ILE A CA  1 
ATOM   138  C  C   . ILE A 1 20  ? 3.39825   -14.87673 9.68595   1.000 18.84567 ? 20  ILE A C   1 
ATOM   139  O  O   . ILE A 1 20  ? 3.02664   -14.90270 8.50505   1.000 14.97546 ? 20  ILE A O   1 
ATOM   140  C  CB  . ILE A 1 20  ? 2.44082   -13.40295 11.51067  1.000 17.14046 ? 20  ILE A CB  1 
ATOM   141  C  CG1 . ILE A 1 20  ? 1.19677   -13.23062 12.36940  1.000 23.01086 ? 20  ILE A CG1 1 
ATOM   142  C  CG2 . ILE A 1 20  ? 2.47036   -12.27263 10.44473  1.000 20.02937 ? 20  ILE A CG2 1 
ATOM   143  C  CD1 . ILE A 1 20  ? 1.22433   -12.00490 13.18928  1.000 27.81517 ? 20  ILE A CD1 1 
ATOM   144  N  N   . LEU A 1 21  ? 4.69163   -14.91726 9.99757   1.000 17.62471 ? 21  LEU A N   1 
ATOM   145  C  CA  . LEU A 1 21  ? 5.66247   -14.97471 8.90673   1.000 16.23977 ? 21  LEU A CA  1 
ATOM   146  C  C   . LEU A 1 21  ? 5.47510   -16.19948 8.01381   1.000 15.00919 ? 21  LEU A C   1 
ATOM   147  O  O   . LEU A 1 21  ? 5.49890   -16.04007 6.77564   1.000 17.58011 ? 21  LEU A O   1 
ATOM   148  C  CB  . LEU A 1 21  ? 7.08791   -14.84931 9.47371   1.000 18.90878 ? 21  LEU A CB  1 
ATOM   149  C  CG  . LEU A 1 21  ? 7.66046   -13.41765 9.45623   1.000 25.19573 ? 21  LEU A CG  1 
ATOM   150  C  CD1 . LEU A 1 21  ? 6.84842   -12.42305 10.24940  1.000 21.12215 ? 21  LEU A CD1 1 
ATOM   151  C  CD2 . LEU A 1 21  ? 9.11613   -13.36161 9.90529   1.000 21.73718 ? 21  LEU A CD2 1 
ATOM   152  N  N   . PRO A 1 22  ? 5.21746   -17.40638 8.52997   1.000 14.80369 ? 22  PRO A N   1 
ATOM   153  C  CA  . PRO A 1 22  ? 5.03596   -18.54622 7.62324   1.000 16.75573 ? 22  PRO A CA  1 
ATOM   154  C  C   . PRO A 1 22  ? 3.82060   -18.41698 6.73691   1.000 13.63201 ? 22  PRO A C   1 
ATOM   155  O  O   . PRO A 1 22  ? 3.79465   -18.99426 5.64716   1.000 15.40019 ? 22  PRO A O   1 
ATOM   156  C  CB  . PRO A 1 22  ? 4.91463   -19.74552 8.58525   1.000 19.21166 ? 22  PRO A CB  1 
ATOM   157  C  CG  . PRO A 1 22  ? 5.71893   -19.31607 9.76650   1.000 20.38016 ? 22  PRO A CG  1 
ATOM   158  C  CD  . PRO A 1 22  ? 5.40696   -17.84706 9.92379   1.000 18.82539 ? 22  PRO A CD  1 
ATOM   159  N  N   . SER A 1 23  ? 2.82257   -17.64956 7.16345   1.000 13.97084 ? 23  SER A N   1 
ATOM   160  C  CA  . SER A 1 23  ? 1.58473   -17.59879 6.39827   1.000 14.24134 ? 23  SER A CA  1 
ATOM   161  C  C   . SER A 1 23  ? 1.78355   -16.94780 5.04199   1.000 13.26514 ? 23  SER A C   1 
ATOM   162  O  O   . SER A 1 23  ? 0.96067   -17.15271 4.13737   1.000 12.48746 ? 23  SER A O   1 
ATOM   163  C  CB  . SER A 1 23  ? 0.51760   -16.84084 7.18139   1.000 15.19410 ? 23  SER A CB  1 
ATOM   164  O  OG  . SER A 1 23  ? 0.79839   -15.44258 7.21969   1.000 12.42900 ? 23  SER A OG  1 
ATOM   165  N  N   . TYR A 1 24  ? 2.85920   -16.18079 4.87413   1.000 14.48500 ? 24  TYR A N   1 
ATOM   166  C  CA  . TYR A 1 24  ? 3.05614   -15.54643 3.57516   1.000 13.89348 ? 24  TYR A CA  1 
ATOM   167  C  C   . TYR A 1 24  ? 3.36758   -16.56833 2.50193   1.000 13.90650 ? 24  TYR A C   1 
ATOM   168  O  O   . TYR A 1 24  ? 3.11409   -16.30235 1.32159   1.000 14.32583 ? 24  TYR A O   1 
ATOM   169  C  CB  . TYR A 1 24  ? 4.15730   -14.49433 3.64436   1.000 12.01740 ? 24  TYR A CB  1 
ATOM   170  C  CG  . TYR A 1 24  ? 3.70640   -13.20783 4.29265   1.000 11.00016 ? 24  TYR A CG  1 
ATOM   171  C  CD1 . TYR A 1 24  ? 3.80744   -13.01509 5.66964   1.000 13.42390 ? 24  TYR A CD1 1 
ATOM   172  C  CD2 . TYR A 1 24  ? 3.18136   -12.18528 3.52217   1.000 12.34743 ? 24  TYR A CD2 1 
ATOM   173  C  CE1 . TYR A 1 24  ? 3.37964   -11.85258 6.25241   1.000 10.40571 ? 24  TYR A CE1 1 
ATOM   174  C  CE2 . TYR A 1 24  ? 2.76400   -11.01667 4.07443   1.000 9.09177  ? 24  TYR A CE2 1 
ATOM   175  C  CZ  . TYR A 1 24  ? 2.83160   -10.83873 5.43694   1.000 13.10449 ? 24  TYR A CZ  1 
ATOM   176  O  OH  . TYR A 1 24  ? 2.40809   -9.64932  5.99236   1.000 10.60284 ? 24  TYR A OH  1 
ATOM   177  N  N   . ASP A 1 25  ? 3.88184   -17.74536 2.89068   1.000 15.24943 ? 25  ASP A N   1 
ATOM   178  C  CA  . ASP A 1 25  ? 4.12932   -18.79515 1.92305   1.000 17.51096 ? 25  ASP A CA  1 
ATOM   179  C  C   . ASP A 1 25  ? 2.84553   -19.38116 1.36893   1.000 16.90657 ? 25  ASP A C   1 
ATOM   180  O  O   . ASP A 1 25  ? 2.89932   -20.06420 0.34668   1.000 21.19482 ? 25  ASP A O   1 
ATOM   181  C  CB  . ASP A 1 25  ? 4.98444   -19.90998 2.56352   1.000 18.88439 ? 25  ASP A CB  1 
ATOM   182  C  CG  . ASP A 1 25  ? 6.39184   -19.45541 2.89092   1.000 25.42015 ? 25  ASP A CG  1 
ATOM   183  O  OD1 . ASP A 1 25  ? 6.96470   -18.63229 2.13838   1.000 25.70137 ? 25  ASP A OD1 1 
ATOM   184  O  OD2 . ASP A 1 25  ? 6.94467   -19.93134 3.90802   1.000 34.98998 ? 25  ASP A OD2 1 
ATOM   185  N  N   . ARG A 1 26  ? 1.70332   -19.14008 2.00852   1.000 14.41345 ? 26  ARG A N   1 
ATOM   186  C  CA  . ARG A 1 26  ? 0.42361   -19.69935 1.60027   1.000 14.60072 ? 26  ARG A CA  1 
ATOM   187  C  C   . ARG A 1 26  ? -0.50028  -18.64486 1.00356   1.000 13.22491 ? 26  ARG A C   1 
ATOM   188  O  O   . ARG A 1 26  ? -1.71827  -18.85738 0.93205   1.000 17.68482 ? 26  ARG A O   1 
ATOM   189  C  CB  . ARG A 1 26  ? -0.25782  -20.38684 2.78578   1.000 19.84957 ? 26  ARG A CB  1 
ATOM   190  C  CG  . ARG A 1 26  ? 0.60388   -21.48123 3.40013   1.000 20.55318 ? 26  ARG A CG  1 
ATOM   191  C  CD  . ARG A 1 26  ? -0.16230  -22.23078 4.48943   1.000 19.12392 ? 26  ARG A CD  1 
ATOM   192  N  NE  . ARG A 1 26  ? -0.78668  -21.35301 5.46956   1.000 24.23883 ? 26  ARG A NE  1 
ATOM   193  C  CZ  . ARG A 1 26  ? -0.21063  -20.93473 6.59049   1.000 26.90447 ? 26  ARG A CZ  1 
ATOM   194  N  NH1 . ARG A 1 26  ? 1.04323   -21.24225 6.87936   1.000 26.35558 ? 26  ARG A NH1 1 
ATOM   195  N  NH2 . ARG A 1 26  ? -0.91181  -20.18128 7.44244   1.000 25.23270 ? 26  ARG A NH2 1 
ATOM   196  N  N   . CYS A 1 27  ? 0.05478   -17.51388 0.57247   1.000 13.97045 ? 27  CYS A N   1 
ATOM   197  C  CA  . CYS A 1 27  ? -0.75474  -16.49711 -0.10956  1.000 13.93322 ? 27  CYS A CA  1 
ATOM   198  C  C   . CYS A 1 27  ? -0.76795  -16.77808 -1.60961  1.000 10.12390 ? 27  CYS A C   1 
ATOM   199  O  O   . CYS A 1 27  ? 0.30442   -16.83277 -2.22522  1.000 12.83335 ? 27  CYS A O   1 
ATOM   200  C  CB  . CYS A 1 27  ? -0.21014  -15.10875 0.15546   1.000 11.07089 ? 27  CYS A CB  1 
ATOM   201  S  SG  . CYS A 1 27  ? -0.49587  -14.51806 1.84984   1.000 14.38326 ? 27  CYS A SG  1 
ATOM   202  N  N   . PRO A 1 28  ? -1.94519  -16.95015 -2.22130  1.000 11.67893 ? 28  PRO A N   1 
ATOM   203  C  CA  . PRO A 1 28  ? -2.02927  -17.18317 -3.67213  1.000 11.57586 ? 28  PRO A CA  1 
ATOM   204  C  C   . PRO A 1 28  ? -1.57806  -15.97276 -4.46994  1.000 12.21061 ? 28  PRO A C   1 
ATOM   205  O  O   . PRO A 1 28  ? -1.65769  -14.84848 -3.99662  1.000 10.34180 ? 28  PRO A O   1 
ATOM   206  C  CB  . PRO A 1 28  ? -3.52464  -17.43312 -3.91373  1.000 15.72075 ? 28  PRO A CB  1 
ATOM   207  C  CG  . PRO A 1 28  ? -4.20091  -17.40137 -2.58668  1.000 20.03578 ? 28  PRO A CG  1 
ATOM   208  C  CD  . PRO A 1 28  ? -3.25749  -16.81978 -1.57346  1.000 14.42548 ? 28  PRO A CD  1 
ATOM   209  N  N   . VAL A 1 29  ? -1.19109  -16.21526 -5.72912  1.000 13.08128 ? 29  VAL A N   1 
ATOM   210  C  CA  . VAL A 1 29  ? -0.80717  -15.12314 -6.62582  1.000 8.92441  ? 29  VAL A CA  1 
ATOM   211  C  C   . VAL A 1 29  ? -1.96765  -14.13455 -6.76813  1.000 9.85166  ? 29  VAL A C   1 
ATOM   212  O  O   . VAL A 1 29  ? -3.15472  -14.50718 -6.76391  1.000 11.51141 ? 29  VAL A O   1 
ATOM   213  C  CB  . VAL A 1 29  ? -0.34285  -15.65252 -7.99746  1.000 11.47474 ? 29  VAL A CB  1 
ATOM   214  C  CG1 . VAL A 1 29  ? -1.52247  -16.19583 -8.82005  1.000 15.40823 ? 29  VAL A CG1 1 
ATOM   215  C  CG2 . VAL A 1 29  ? 0.39137   -14.57825 -8.77058  1.000 14.40794 ? 29  VAL A CG2 1 
ATOM   216  N  N   . ASP A 1 30  ? -1.61287  -12.85425 -6.83444  1.000 8.98366  ? 30  ASP A N   1 
ATOM   217  C  CA  . ASP A 1 30  ? -2.56381  -11.77269 -7.11718  1.000 7.77576  ? 30  ASP A CA  1 
ATOM   218  C  C   . ASP A 1 30  ? -2.81063  -11.75020 -8.61733  1.000 10.57036 ? 30  ASP A C   1 
ATOM   219  O  O   . ASP A 1 30  ? -1.89276  -11.44982 -9.38981  1.000 9.69750  ? 30  ASP A O   1 
ATOM   220  C  CB  . ASP A 1 30  ? -1.96548  -10.45879 -6.62848  1.000 8.54341  ? 30  ASP A CB  1 
ATOM   221  C  CG  . ASP A 1 30  ? -2.90252  -9.25410  -6.75083  1.000 9.49899  ? 30  ASP A CG  1 
ATOM   222  O  OD1 . ASP A 1 30  ? -3.93433  -9.29668  -7.47655  1.000 8.45219  ? 30  ASP A OD1 1 
ATOM   223  O  OD2 . ASP A 1 30  ? -2.56218  -8.24748  -6.07891  1.000 11.83035 ? 30  ASP A OD2 1 
ATOM   224  N  N   . ASP A 1 31  ? -4.03235  -12.11048 -9.04558  1.000 7.17440  ? 31  ASP A N   1 
ATOM   225  C  CA  . ASP A 1 31  ? -4.29755  -12.20008 -10.47640 1.000 9.50047  ? 31  ASP A CA  1 
ATOM   226  C  C   . ASP A 1 31  ? -4.45958  -10.84316 -11.13795 1.000 8.20424  ? 31  ASP A C   1 
ATOM   227  O  O   . ASP A 1 31  ? -4.53449  -10.77379 -12.37341 1.000 11.57771 ? 31  ASP A O   1 
ATOM   228  C  CB  . ASP A 1 31  ? -5.56526  -13.01799 -10.74629 1.000 12.66510 ? 31  ASP A CB  1 
ATOM   229  C  CG  . ASP A 1 31  ? -5.39774  -14.47773 -10.37566 1.000 26.69862 ? 31  ASP A CG  1 
ATOM   230  O  OD1 . ASP A 1 31  ? -4.35156  -15.05992 -10.73811 1.000 21.51000 ? 31  ASP A OD1 1 
ATOM   231  O  OD2 . ASP A 1 31  ? -6.30155  -15.02662 -9.70335  1.000 32.22861 ? 31  ASP A OD2 1 
ATOM   232  N  N   . TYR A 1 32  ? -4.48625  -9.76255  -10.36973 1.000 9.24927  ? 32  TYR A N   1 
ATOM   233  C  CA  . TYR A 1 32  ? -4.89797  -8.47756  -10.90324 1.000 9.16647  ? 32  TYR A CA  1 
ATOM   234  C  C   . TYR A 1 32  ? -3.82228  -7.42255  -10.91010 1.000 9.55278  ? 32  TYR A C   1 
ATOM   235  O  O   . TYR A 1 32  ? -3.96557  -6.41914  -11.62931 1.000 12.14615 ? 32  TYR A O   1 
ATOM   236  C  CB  . TYR A 1 32  ? -6.06373  -7.92592  -10.09091 1.000 9.05020  ? 32  TYR A CB  1 
ATOM   237  C  CG  . TYR A 1 32  ? -7.18522  -8.91334  -9.95710  1.000 8.46594  ? 32  TYR A CG  1 
ATOM   238  C  CD1 . TYR A 1 32  ? -8.17739  -9.01410  -10.94212 1.000 9.95902  ? 32  TYR A CD1 1 
ATOM   239  C  CD2 . TYR A 1 32  ? -7.27641  -9.71915  -8.83846  1.000 10.77041 ? 32  TYR A CD2 1 
ATOM   240  C  CE1 . TYR A 1 32  ? -9.24698  -9.89869  -10.80327 1.000 12.04996 ? 32  TYR A CE1 1 
ATOM   241  C  CE2 . TYR A 1 32  ? -8.34156  -10.62220 -8.68588  1.000 12.48458 ? 32  TYR A CE2 1 
ATOM   242  C  CZ  . TYR A 1 32  ? -9.33113  -10.69708 -9.67697  1.000 9.80929  ? 32  TYR A CZ  1 
ATOM   243  O  OH  . TYR A 1 32  ? -10.37829 -11.59467 -9.52836  1.000 13.94606 ? 32  TYR A OH  1 
ATOM   244  N  N   . MET A 1 33  ? -2.80572  -7.57335  -10.07938 1.000 8.18248  ? 33  MET A N   1 
ATOM   245  C  CA  A MET A 1 33  ? -1.74640  -6.59284  -9.97137  0.615 8.83396  ? 33  MET A CA  1 
ATOM   246  C  CA  B MET A 1 33  ? -1.74981  -6.59050  -9.92930  0.385 8.87410  ? 33  MET A CA  1 
ATOM   247  C  C   . MET A 1 33  ? -0.41331  -7.29383  -9.83814  1.000 7.68081  ? 33  MET A C   1 
ATOM   248  O  O   . MET A 1 33  ? -0.32368  -8.40453  -9.30264  1.000 10.04273 ? 33  MET A O   1 
ATOM   249  C  CB  A MET A 1 33  ? -1.96128  -5.65936  -8.78233  0.615 10.28548 ? 33  MET A CB  1 
ATOM   250  C  CB  B MET A 1 33  ? -1.91528  -5.73483  -8.67388  0.385 10.28479 ? 33  MET A CB  1 
ATOM   251  C  CG  A MET A 1 33  ? -3.16043  -4.78228  -8.97173  0.615 8.16369  ? 33  MET A CG  1 
ATOM   252  C  CG  B MET A 1 33  ? -1.52769  -4.30648  -8.92050  0.385 15.42561 ? 33  MET A CG  1 
ATOM   253  S  SD  A MET A 1 33  ? -3.22170  -3.44129  -7.79968  0.615 17.85105 ? 33  MET A SD  1 
ATOM   254  S  SD  B MET A 1 33  ? -2.97425  -3.51617  -9.62123  0.385 11.37839 ? 33  MET A SD  1 
ATOM   255  C  CE  A MET A 1 33  ? -1.89489  -2.37000  -8.34507  0.615 15.51783 ? 33  MET A CE  1 
ATOM   256  C  CE  B MET A 1 33  ? -3.77253  -3.00315  -8.12722  0.385 15.32607 ? 33  MET A CE  1 
ATOM   257  N  N   . GLY A 1 34  ? 0.59263   -6.61893  -10.35562 1.000 6.43350  ? 34  GLY A N   1 
ATOM   258  C  CA  . GLY A 1 34  ? 1.98112   -7.02027  -10.20967 1.000 9.61233  ? 34  GLY A CA  1 
ATOM   259  C  C   . GLY A 1 34  ? 2.46575   -8.01803  -11.22422 1.000 10.40392 ? 34  GLY A C   1 
ATOM   260  O  O   . GLY A 1 34  ? 3.62661   -8.43077  -11.15429 1.000 8.10464  ? 34  GLY A O   1 
ATOM   261  N  N   . ASN A 1 35  ? 1.62653   -8.41429  -12.18008 1.000 7.56752  ? 35  ASN A N   1 
ATOM   262  C  CA  . ASN A 1 35  ? 2.06351   -9.26090  -13.29440 1.000 6.34747  ? 35  ASN A CA  1 
ATOM   263  C  C   . ASN A 1 35  ? 2.85686   -10.48557 -12.82667 1.000 8.00135  ? 35  ASN A C   1 
ATOM   264  O  O   . ASN A 1 35  ? 3.92720   -10.82752 -13.35901 1.000 10.85414 ? 35  ASN A O   1 
ATOM   265  C  CB  . ASN A 1 35  ? 2.81775   -8.42233  -14.32148 1.000 7.21151  ? 35  ASN A CB  1 
ATOM   266  C  CG  . ASN A 1 35  ? 1.88298   -7.52882  -15.07719 1.000 8.77705  ? 35  ASN A CG  1 
ATOM   267  O  OD1 . ASN A 1 35  ? 1.18936   -8.00672  -15.97854 1.000 8.83836  ? 35  ASN A OD1 1 
ATOM   268  N  ND2 . ASN A 1 35  ? 1.81857   -6.25381  -14.71305 1.000 8.59033  ? 35  ASN A ND2 1 
ATOM   269  N  N   . GLY A 1 36  ? 2.27866   -11.17297 -11.84137 1.000 8.70299  ? 36  GLY A N   1 
ATOM   270  C  CA  . GLY A 1 36  ? 2.81464   -12.42383 -11.36094 1.000 10.02564 ? 36  GLY A CA  1 
ATOM   271  C  C   . GLY A 1 36  ? 3.84971   -12.30274 -10.26977 1.000 10.95744 ? 36  GLY A C   1 
ATOM   272  O  O   . GLY A 1 36  ? 4.32264   -13.34846 -9.78952  1.000 14.36424 ? 36  GLY A O   1 
ATOM   273  N  N   . THR A 1 37  ? 4.25825   -11.08052 -9.90749  1.000 8.66105  ? 37  THR A N   1 
ATOM   274  C  CA  . THR A 1 37  ? 5.25448   -10.86985 -8.84294  1.000 8.69394  ? 37  THR A CA  1 
ATOM   275  C  C   . THR A 1 37  ? 4.64341   -10.72755 -7.45877  1.000 8.78116  ? 37  THR A C   1 
ATOM   276  O  O   . THR A 1 37  ? 5.40271   -10.63622 -6.48066  1.000 9.22530  ? 37  THR A O   1 
ATOM   277  C  CB  . THR A 1 37  ? 6.11703   -9.62929  -9.09752  1.000 8.34231  ? 37  THR A CB  1 
ATOM   278  O  OG1 . THR A 1 37  ? 5.31650   -8.45156  -9.00773  1.000 9.99856  ? 37  THR A OG1 1 
ATOM   279  C  CG2 . THR A 1 37  ? 6.79652   -9.68242  -10.51031 1.000 10.07911 ? 37  THR A CG2 1 
ATOM   280  N  N   . ARG A 1 38  ? 3.32042   -10.66410 -7.35948  1.000 7.84304  ? 38  ARG A N   1 
ATOM   281  C  CA  . ARG A 1 38  ? 2.62963   -10.34358 -6.10506  1.000 6.34807  ? 38  ARG A CA  1 
ATOM   282  C  C   . ARG A 1 38  ? 1.69576   -11.47728 -5.68396  1.000 8.39509  ? 38  ARG A C   1 
ATOM   283  O  O   . ARG A 1 38  ? 1.05857   -12.12752 -6.52863  1.000 8.84030  ? 38  ARG A O   1 
ATOM   284  C  CB  . ARG A 1 38  ? 1.83419   -9.03909  -6.27764  1.000 8.18351  ? 38  ARG A CB  1 
ATOM   285  C  CG  . ARG A 1 38  ? 1.26942   -8.50358  -4.98912  1.000 8.96187  ? 38  ARG A CG  1 
ATOM   286  C  CD  . ARG A 1 38  ? 0.57524   -7.17089  -5.24826  1.000 13.55313 ? 38  ARG A CD  1 
ATOM   287  N  NE  . ARG A 1 38  ? 1.54443   -6.18014  -5.68528  1.000 11.93366 ? 38  ARG A NE  1 
ATOM   288  C  CZ  . ARG A 1 38  ? 1.26904   -4.88536  -5.72234  1.000 15.46910 ? 38  ARG A CZ  1 
ATOM   289  N  NH1 . ARG A 1 38  ? 0.06023   -4.44466  -5.40463  1.000 12.98356 ? 38  ARG A NH1 1 
ATOM   290  N  NH2 . ARG A 1 38  ? 2.22310   -4.01859  -6.08551  1.000 15.52797 ? 38  ARG A NH2 1 
ATOM   291  N  N   . PHE A 1 39  ? 1.60161   -11.68841 -4.36891  1.000 6.65134  ? 39  PHE A N   1 
ATOM   292  C  CA  . PHE A 1 39  ? 0.78415   -12.71150 -3.74897  1.000 8.76939  ? 39  PHE A CA  1 
ATOM   293  C  C   . PHE A 1 39  ? 0.01883   -12.02552 -2.62791  1.000 10.20674 ? 39  PHE A C   1 
ATOM   294  O  O   . PHE A 1 39  ? 0.56117   -11.13686 -1.95892  1.000 10.60953 ? 39  PHE A O   1 
ATOM   295  C  CB  . PHE A 1 39  ? 1.69308   -13.86302 -3.24189  1.000 9.94468  ? 39  PHE A CB  1 
ATOM   296  C  CG  . PHE A 1 39  ? 2.54824   -14.42444 -4.32585  1.000 14.53591 ? 39  PHE A CG  1 
ATOM   297  C  CD1 . PHE A 1 39  ? 3.69264   -13.76495 -4.74908  1.000 13.15480 ? 39  PHE A CD1 1 
ATOM   298  C  CD2 . PHE A 1 39  ? 2.18846   -15.61806 -4.95192  1.000 12.91151 ? 39  PHE A CD2 1 
ATOM   299  C  CE1 . PHE A 1 39  ? 4.44739   -14.24376 -5.81564  1.000 15.26636 ? 39  PHE A CE1 1 
ATOM   300  C  CE2 . PHE A 1 39  ? 2.95614   -16.10796 -6.01587  1.000 15.32551 ? 39  PHE A CE2 1 
ATOM   301  C  CZ  . PHE A 1 39  ? 4.07108   -15.43262 -6.44256  1.000 16.44295 ? 39  PHE A CZ  1 
ATOM   302  N  N   . LYS A 1 40  ? -1.24478  -12.38924 -2.44809  1.000 9.00033  ? 40  LYS A N   1 
ATOM   303  C  CA  . LYS A 1 40  ? -2.12246  -11.56371 -1.61862  1.000 9.66185  ? 40  LYS A CA  1 
ATOM   304  C  C   . LYS A 1 40  ? -3.19508  -12.39709 -0.92830  1.000 11.32246 ? 40  LYS A C   1 
ATOM   305  O  O   . LYS A 1 40  ? -3.70220  -13.35559 -1.50693  1.000 11.78467 ? 40  LYS A O   1 
ATOM   306  C  CB  . LYS A 1 40  ? -2.81189  -10.50284 -2.50275  1.000 13.40724 ? 40  LYS A CB  1 
ATOM   307  C  CG  . LYS A 1 40  ? -3.76533  -9.57512  -1.80812  1.000 20.68491 ? 40  LYS A CG  1 
ATOM   308  C  CD  . LYS A 1 40  ? -4.16138  -8.51452  -2.81677  1.000 23.47288 ? 40  LYS A CD  1 
ATOM   309  C  CE  . LYS A 1 40  ? -4.48448  -7.22156  -2.17638  1.000 25.64861 ? 40  LYS A CE  1 
ATOM   310  N  NZ  . LYS A 1 40  ? -3.22445  -6.43595  -2.07133  1.000 19.98949 ? 40  LYS A NZ  1 
ATOM   311  N  N   . ARG A 1 41  ? -3.54045  -12.01522 0.30067   1.000 7.38855  ? 41  ARG A N   1 
ATOM   312  C  CA  . ARG A 1 41  ? -4.83474  -12.32648 0.88881   1.000 8.52416  ? 41  ARG A CA  1 
ATOM   313  C  C   . ARG A 1 41  ? -5.44378  -11.02493 1.39640   1.000 7.14481  ? 41  ARG A C   1 
ATOM   314  O  O   . ARG A 1 41  ? -4.73959  -10.01314 1.59016   1.000 9.03712  ? 41  ARG A O   1 
ATOM   315  C  CB  . ARG A 1 41  ? -4.72684  -13.36215 2.03396   1.000 7.51676  ? 41  ARG A CB  1 
ATOM   316  C  CG  . ARG A 1 41  ? -4.29282  -14.74139 1.54151   1.000 11.08424 ? 41  ARG A CG  1 
ATOM   317  C  CD  . ARG A 1 41  ? -4.17279  -15.68243 2.72366   1.000 9.40561  ? 41  ARG A CD  1 
ATOM   318  N  NE  . ARG A 1 41  ? -3.83321  -17.03055 2.28103   1.000 11.72684 ? 41  ARG A NE  1 
ATOM   319  C  CZ  . ARG A 1 41  ? -4.75203  -17.94260 2.01982   1.000 12.19946 ? 41  ARG A CZ  1 
ATOM   320  N  NH1 . ARG A 1 41  ? -6.03823  -17.69602 2.20860   1.000 14.51853 ? 41  ARG A NH1 1 
ATOM   321  N  NH2 . ARG A 1 41  ? -4.37350  -19.13914 1.56595   1.000 17.00297 ? 41  ARG A NH2 1 
ATOM   322  N  N   . PHE A 1 42  ? -6.76238  -11.03666 1.62800   1.000 7.49744  ? 42  PHE A N   1 
ATOM   323  C  CA  . PHE A 1 42  ? -7.48747  -9.78998  1.86938   1.000 7.34561  ? 42  PHE A CA  1 
ATOM   324  C  C   . PHE A 1 42  ? -8.63311  -10.03228 2.82500   1.000 8.89025  ? 42  PHE A C   1 
ATOM   325  O  O   . PHE A 1 42  ? -9.42472  -10.95149 2.60925   1.000 9.47434  ? 42  PHE A O   1 
ATOM   326  C  CB  . PHE A 1 42  ? -8.04059  -9.26802  0.53082   1.000 7.89519  ? 42  PHE A CB  1 
ATOM   327  C  CG  . PHE A 1 42  ? -8.99367  -8.08554  0.64954   1.000 6.95531  ? 42  PHE A CG  1 
ATOM   328  C  CD1 . PHE A 1 42  ? -8.53164  -6.78858  0.94803   1.000 8.25006  ? 42  PHE A CD1 1 
ATOM   329  C  CD2 . PHE A 1 42  ? -10.33996 -8.24565  0.36678   1.000 10.77291 ? 42  PHE A CD2 1 
ATOM   330  C  CE1 . PHE A 1 42  ? -9.47704  -5.70704  0.99459   1.000 7.57733  ? 42  PHE A CE1 1 
ATOM   331  C  CE2 . PHE A 1 42  ? -11.24760 -7.17102  0.42331   1.000 9.23486  ? 42  PHE A CE2 1 
ATOM   332  C  CZ  . PHE A 1 42  ? -10.80973 -5.92551  0.70631   1.000 8.61259  ? 42  PHE A CZ  1 
ATOM   333  N  N   . SER A 1 43  ? -8.77198  -9.16522  3.83020   1.000 7.28806  ? 43  SER A N   1 
ATOM   334  C  CA  A SER A 1 43  ? -9.90976  -9.24446  4.73867   0.916 8.74778  ? 43  SER A CA  1 
ATOM   335  C  CA  B SER A 1 43  ? -9.90620  -9.24487  4.73726   0.084 8.76248  ? 43  SER A CA  1 
ATOM   336  C  C   . SER A 1 43  ? -10.29058 -7.83756  5.16378   1.000 6.64217  ? 43  SER A C   1 
ATOM   337  O  O   . SER A 1 43  ? -9.50404  -6.89485  5.05316   1.000 7.62882  ? 43  SER A O   1 
ATOM   338  C  CB  A SER A 1 43  ? -9.63776  -10.09764 5.99484   0.916 9.56721  ? 43  SER A CB  1 
ATOM   339  C  CB  B SER A 1 43  ? -9.61070  -10.12373 5.96559   0.084 9.67061  ? 43  SER A CB  1 
ATOM   340  O  OG  A SER A 1 43  ? -9.50361  -11.47488 5.65981   0.916 9.78054  ? 43  SER A OG  1 
ATOM   341  O  OG  B SER A 1 43  ? -8.66334  -9.52219  6.82609   0.084 10.30967 ? 43  SER A OG  1 
ATOM   342  N  N   . GLN A 1 44  ? -11.52686 -7.70710  5.64990   1.000 7.88007  ? 44  GLN A N   1 
ATOM   343  C  CA  . GLN A 1 44  ? -12.05235 -6.41817  6.06364   1.000 6.71114  ? 44  GLN A CA  1 
ATOM   344  C  C   . GLN A 1 44  ? -12.66250 -6.52937  7.44959   1.000 9.27048  ? 44  GLN A C   1 
ATOM   345  O  O   . GLN A 1 44  ? -13.21140 -7.57503  7.81048   1.000 11.15703 ? 44  GLN A O   1 
ATOM   346  C  CB  . GLN A 1 44  ? -13.09960 -5.91982  5.08214   1.000 8.14899  ? 44  GLN A CB  1 
ATOM   347  C  CG  . GLN A 1 44  ? -12.47540 -5.66785  3.69632   1.000 9.78936  ? 44  GLN A CG  1 
ATOM   348  C  CD  . GLN A 1 44  ? -13.52437 -5.37837  2.64720   1.000 9.99564  ? 44  GLN A CD  1 
ATOM   349  O  OE1 . GLN A 1 44  ? -14.23898 -6.27780  2.21412   1.000 11.23201 ? 44  GLN A OE1 1 
ATOM   350  N  NE2 . GLN A 1 44  ? -13.63270 -4.11488  2.23774   1.000 8.72715  ? 44  GLN A NE2 1 
ATOM   351  N  N   . TYR A 1 45  ? -12.51536 -5.47060  8.23232   1.000 9.04093  ? 45  TYR A N   1 
ATOM   352  C  CA  . TYR A 1 45  ? -12.97493 -5.49450  9.61457   1.000 11.02680 ? 45  TYR A CA  1 
ATOM   353  C  C   . TYR A 1 45  ? -13.74678 -4.23072  9.94437   1.000 10.07032 ? 45  TYR A C   1 
ATOM   354  O  O   . TYR A 1 45  ? -13.47956 -3.14425  9.40962   1.000 10.04887 ? 45  TYR A O   1 
ATOM   355  C  CB  . TYR A 1 45  ? -11.82371 -5.56731  10.61224  1.000 8.51784  ? 45  TYR A CB  1 
ATOM   356  C  CG  . TYR A 1 45  ? -10.97123 -6.79912  10.55995  1.000 9.85385  ? 45  TYR A CG  1 
ATOM   357  C  CD1 . TYR A 1 45  ? -10.00243 -6.94611  9.58102   1.000 10.73199 ? 45  TYR A CD1 1 
ATOM   358  C  CD2 . TYR A 1 45  ? -11.11151 -7.79488  11.53810  1.000 11.96040 ? 45  TYR A CD2 1 
ATOM   359  C  CE1 . TYR A 1 45  ? -9.22000  -8.08561  9.54020   1.000 17.68434 ? 45  TYR A CE1 1 
ATOM   360  C  CE2 . TYR A 1 45  ? -10.32943 -8.91157  11.51354  1.000 18.94758 ? 45  TYR A CE2 1 
ATOM   361  C  CZ  . TYR A 1 45  ? -9.39817  -9.05193  10.52007  1.000 17.58731 ? 45  TYR A CZ  1 
ATOM   362  O  OH  . TYR A 1 45  ? -8.62437  -10.17941 10.51795  1.000 23.23588 ? 45  TYR A OH  1 
ATOM   363  N  N   . LYS A 1 46  ? -14.71280 -4.38920  10.85644  1.000 10.30243 ? 46  LYS A N   1 
ATOM   364  C  CA  . LYS A 1 46  ? -15.27726 -3.26838  11.58936  1.000 8.72139  ? 46  LYS A CA  1 
ATOM   365  C  C   . LYS A 1 46  ? -14.44718 -3.01698  12.84215  1.000 11.05640 ? 46  LYS A C   1 
ATOM   366  O  O   . LYS A 1 46  ? -14.06042 -3.95001  13.55419  1.000 12.90763 ? 46  LYS A O   1 
ATOM   367  C  CB  . LYS A 1 46  ? -16.73263 -3.55442  11.96802  1.000 11.85587 ? 46  LYS A CB  1 
ATOM   368  C  CG  . LYS A 1 46  ? -17.39936 -2.36070  12.62856  1.000 10.92660 ? 46  LYS A CG  1 
ATOM   369  C  CD  . LYS A 1 46  ? -18.88977 -2.68054  12.86146  1.000 10.93561 ? 46  LYS A CD  1 
ATOM   370  C  CE  . LYS A 1 46  ? -19.64210 -1.47813  13.33648  1.000 15.76879 ? 46  LYS A CE  1 
ATOM   371  N  NZ  . LYS A 1 46  ? -21.05660 -1.89037  13.65157  1.000 11.57604 ? 46  LYS A NZ  1 
ATOM   372  N  N   . LEU A 1 47  ? -14.17030 -1.75335  13.10292  1.000 10.44963 ? 47  LEU A N   1 
ATOM   373  C  CA  . LEU A 1 47  ? -13.24477 -1.33771  14.14919  1.000 12.65777 ? 47  LEU A CA  1 
ATOM   374  C  C   . LEU A 1 47  ? -13.96486 -0.37981  15.10077  1.000 21.64416 ? 47  LEU A C   1 
ATOM   375  O  O   . LEU A 1 47  ? -14.39655 0.70266   14.69103  1.000 17.86768 ? 47  LEU A O   1 
ATOM   376  C  CB  . LEU A 1 47  ? -12.00379 -0.70095  13.49717  1.000 17.20287 ? 47  LEU A CB  1 
ATOM   377  C  CG  . LEU A 1 47  ? -10.89451 -0.14355  14.36142  1.000 18.35595 ? 47  LEU A CG  1 
ATOM   378  C  CD1 . LEU A 1 47  ? -10.38350 -1.24412  15.28196  1.000 22.48023 ? 47  LEU A CD1 1 
ATOM   379  C  CD2 . LEU A 1 47  ? -9.77854  0.37323   13.45128  1.000 15.23213 ? 47  LEU A CD2 1 
ATOM   380  N  N   . THR A 1 48  ? -14.13924 -0.79051  16.36877  1.000 21.16157 ? 48  THR A N   1 
ATOM   381  C  CA  . THR A 1 48  ? -14.96147 0.02733   17.26025  1.000 20.85758 ? 48  THR A CA  1 
ATOM   382  C  C   . THR A 1 48  ? -14.23773 0.30548   18.57153  1.000 21.38130 ? 48  THR A C   1 
ATOM   383  O  O   . THR A 1 48  ? -13.51194 -0.55512  19.09389  1.000 19.26906 ? 48  THR A O   1 
ATOM   384  C  CB  . THR A 1 48  ? -16.31395 -0.63847  17.57013  1.000 25.63451 ? 48  THR A CB  1 
ATOM   385  O  OG1 . THR A 1 48  ? -16.09284 -1.96193  18.05366  1.000 30.91759 ? 48  THR A OG1 1 
ATOM   386  C  CG2 . THR A 1 48  ? -17.19309 -0.70356  16.33430  1.000 22.86726 ? 48  THR A CG2 1 
ATOM   387  N  N   . PRO A 1 49  ? -14.40258 1.49811   19.12879  1.000 24.98915 ? 49  PRO A N   1 
ATOM   388  C  CA  . PRO A 1 49  ? -13.74185 1.80150   20.40711  1.000 26.82830 ? 49  PRO A CA  1 
ATOM   389  C  C   . PRO A 1 49  ? -14.33136 0.97261   21.54107  1.000 32.86918 ? 49  PRO A C   1 
ATOM   390  O  O   . PRO A 1 49  ? -15.54565 0.77756   21.62497  1.000 32.44852 ? 49  PRO A O   1 
ATOM   391  C  CB  . PRO A 1 49  ? -14.00593 3.29811   20.59838  1.000 32.38738 ? 49  PRO A CB  1 
ATOM   392  C  CG  . PRO A 1 49  ? -15.20299 3.57863   19.74213  1.000 30.08061 ? 49  PRO A CG  1 
ATOM   393  C  CD  . PRO A 1 49  ? -15.06874 2.67334   18.55440  1.000 23.64074 ? 49  PRO A CD  1 
ATOM   394  N  N   . ALA A 1 50  ? -13.45634 0.48899   22.41235  1.000 38.27842 ? 50  ALA A N   1 
ATOM   395  C  CA  . ALA A 1 50  ? -13.82536 -0.37223  23.52258  1.000 51.22054 ? 50  ALA A CA  1 
ATOM   396  C  C   . ALA A 1 50  ? -13.42926 0.30293   24.83030  1.000 47.50899 ? 50  ALA A C   1 
ATOM   397  O  O   . ALA A 1 50  ? -12.48340 1.09505   24.86781  1.000 44.38774 ? 50  ALA A O   1 
ATOM   398  C  CB  . ALA A 1 50  ? -13.14472 -1.73824  23.38616  1.000 38.42906 ? 50  ALA A CB  1 
ATOM   399  N  N   . GLU A 1 51  ? -14.17046 0.00089   25.90272  1.000 56.88512 ? 51  GLU A N   1 
ATOM   400  C  CA  . GLU A 1 51  ? -13.90817 0.62814   27.19714  1.000 64.91737 ? 51  GLU A CA  1 
ATOM   401  C  C   . GLU A 1 51  ? -12.49728 0.27162   27.67116  1.000 56.92330 ? 51  GLU A C   1 
ATOM   402  O  O   . GLU A 1 51  ? -11.87503 -0.66387  27.14822  1.000 52.49945 ? 51  GLU A O   1 
ATOM   403  C  CB  . GLU A 1 51  ? -14.98339 0.23916   28.22566  1.000 72.07570 ? 51  GLU A CB  1 
ATOM   404  C  CG  . GLU A 1 51  ? -14.85358 0.88629   29.61854  1.000 76.75302 ? 51  GLU A CG  1 
ATOM   405  C  CD  . GLU A 1 51  ? -14.69111 2.40370   29.57399  1.000 77.14226 ? 51  GLU A CD  1 
ATOM   406  O  OE1 . GLU A 1 51  ? -15.42320 3.05816   28.79873  1.000 77.78959 ? 51  GLU A OE1 1 
ATOM   407  O  OE2 . GLU A 1 51  ? -13.83000 2.93613   30.31584  1.000 78.84654 ? 51  GLU A OE2 1 
ATOM   408  N  N   . ASP A 1 52  ? -11.97445 1.04220   28.63547  1.000 57.88317 ? 52  ASP A N   1 
ATOM   409  C  CA  . ASP A 1 52  ? -10.57493 0.97498   29.05472  1.000 60.90129 ? 52  ASP A CA  1 
ATOM   410  C  C   . ASP A 1 52  ? -9.65133  1.40877   27.91747  1.000 54.20064 ? 52  ASP A C   1 
ATOM   411  O  O   . ASP A 1 52  ? -8.47889  1.02870   27.86603  1.000 57.91389 ? 52  ASP A O   1 
ATOM   412  C  CB  . ASP A 1 52  ? -10.22739 -0.42181  29.58235  1.000 64.61055 ? 52  ASP A CB  1 
ATOM   413  C  CG  . ASP A 1 52  ? -11.25684 -0.93359  30.58960  1.000 69.95524 ? 52  ASP A CG  1 
ATOM   414  O  OD1 . ASP A 1 52  ? -11.89403 -0.10330  31.26132  1.000 66.07668 ? 52  ASP A OD1 1 
ATOM   415  O  OD2 . ASP A 1 52  ? -11.44559 -2.16734  30.69845  1.000 80.54476 ? 52  ASP A OD2 1 
ATOM   416  N  N   . ASP A 1 53  ? -10.20521 2.21277   27.00275  1.000 52.87903 ? 53  ASP A N   1 
ATOM   417  C  CA  . ASP A 1 53  ? -9.44381  2.96071   25.99982  1.000 50.94914 ? 53  ASP A CA  1 
ATOM   418  C  C   . ASP A 1 53  ? -8.73471  2.04044   25.00599  1.000 52.77365 ? 53  ASP A C   1 
ATOM   419  O  O   . ASP A 1 53  ? -7.60340  2.29517   24.58709  1.000 49.71902 ? 53  ASP A O   1 
ATOM   420  C  CB  . ASP A 1 53  ? -8.45402  3.91426   26.66539  1.000 53.88644 ? 53  ASP A CB  1 
ATOM   421  C  CG  . ASP A 1 53  ? -8.19876  5.15071   25.83169  1.000 66.78991 ? 53  ASP A CG  1 
ATOM   422  O  OD1 . ASP A 1 53  ? -9.09359  6.02889   25.77137  1.000 66.39124 ? 53  ASP A OD1 1 
ATOM   423  O  OD2 . ASP A 1 53  ? -7.10721  5.23707   25.22784  1.000 75.72814 ? 53  ASP A OD2 1 
ATOM   424  N  N   . THR A 1 54  ? -9.41426  0.97685   24.60645  1.000 45.40436 ? 54  THR A N   1 
ATOM   425  C  CA  . THR A 1 54  ? -8.90917  0.03243   23.62432  1.000 43.95055 ? 54  THR A CA  1 
ATOM   426  C  C   . THR A 1 54  ? -9.84953  0.01447   22.42189  1.000 31.57485 ? 54  THR A C   1 
ATOM   427  O  O   . THR A 1 54  ? -10.80041 0.80140   22.34124  1.000 28.96198 ? 54  THR A O   1 
ATOM   428  C  CB  . THR A 1 54  ? -8.77883  -1.35860  24.23910  1.000 44.11781 ? 54  THR A CB  1 
ATOM   429  O  OG1 . THR A 1 54  ? -10.08663 -1.85221  24.56276  1.000 39.20008 ? 54  THR A OG1 1 
ATOM   430  C  CG2 . THR A 1 54  ? -7.92939  -1.29950  25.50548  1.000 44.64130 ? 54  THR A CG2 1 
ATOM   431  N  N   . TRP A 1 55  ? -9.58438  -0.91355  21.49578  1.000 31.96884 ? 55  TRP A N   1 
ATOM   432  C  CA  . TRP A 1 55  ? -10.39947 -1.10614  20.30421  1.000 24.58609 ? 55  TRP A CA  1 
ATOM   433  C  C   . TRP A 1 55  ? -10.69383 -2.58239  20.10771  1.000 18.53967 ? 55  TRP A C   1 
ATOM   434  O  O   . TRP A 1 55  ? -9.87147  -3.44750  20.42619  1.000 30.93584 ? 55  TRP A O   1 
ATOM   435  C  CB  . TRP A 1 55  ? -9.70254  -0.56386  19.03428  1.000 23.39510 ? 55  TRP A CB  1 
ATOM   436  C  CG  . TRP A 1 55  ? -9.56336  0.92514   19.04186  1.000 20.88027 ? 55  TRP A CG  1 
ATOM   437  C  CD1 . TRP A 1 55  ? -8.65095  1.66945   19.74293  1.000 26.15241 ? 55  TRP A CD1 1 
ATOM   438  C  CD2 . TRP A 1 55  ? -10.37183 1.85484   18.32132  1.000 19.74018 ? 55  TRP A CD2 1 
ATOM   439  N  NE1 . TRP A 1 55  ? -8.85319  3.01297   19.50313  1.000 26.98336 ? 55  TRP A NE1 1 
ATOM   440  C  CE2 . TRP A 1 55  ? -9.90282  3.15368   18.63793  1.000 19.93206 ? 55  TRP A CE2 1 
ATOM   441  C  CE3 . TRP A 1 55  ? -11.45792 1.71862   17.44810  1.000 18.32515 ? 55  TRP A CE3 1 
ATOM   442  C  CZ2 . TRP A 1 55  ? -10.45863 4.30034   18.08251  1.000 21.55493 ? 55  TRP A CZ2 1 
ATOM   443  C  CZ3 . TRP A 1 55  ? -12.01440 2.86475   16.90092  1.000 23.19593 ? 55  TRP A CZ3 1 
ATOM   444  C  CH2 . TRP A 1 55  ? -11.51621 4.14320   17.23746  1.000 21.88216 ? 55  TRP A CH2 1 
ATOM   445  N  N   . SER A 1 56  ? -11.86277 -2.84448  19.54914  1.000 20.31233 ? 56  SER A N   1 
ATOM   446  C  CA  . SER A 1 56  ? -12.35651 -4.17445  19.21992  1.000 25.59782 ? 56  SER A CA  1 
ATOM   447  C  C   . SER A 1 56  ? -12.47090 -4.32226  17.71007  1.000 20.54576 ? 56  SER A C   1 
ATOM   448  O  O   . SER A 1 56  ? -12.92078 -3.39839  17.02037  1.000 19.50485 ? 56  SER A O   1 
ATOM   449  C  CB  . SER A 1 56  ? -13.72399 -4.40952  19.85839  1.000 26.31289 ? 56  SER A CB  1 
ATOM   450  O  OG  . SER A 1 56  ? -14.44023 -5.43264  19.19686  1.000 39.49474 ? 56  SER A OG  1 
ATOM   451  N  N   . PHE A 1 57  ? -12.10948 -5.50274  17.21628  1.000 18.17692 ? 57  PHE A N   1 
ATOM   452  C  CA  . PHE A 1 57  ? -12.12549 -5.82325  15.79683  1.000 15.49561 ? 57  PHE A CA  1 
ATOM   453  C  C   . PHE A 1 57  ? -13.18391 -6.88214  15.51223  1.000 22.01933 ? 57  PHE A C   1 
ATOM   454  O  O   . PHE A 1 57  ? -13.26836 -7.89342  16.22190  1.000 18.72524 ? 57  PHE A O   1 
ATOM   455  C  CB  . PHE A 1 57  ? -10.77785 -6.36467  15.34842  1.000 16.54489 ? 57  PHE A CB  1 
ATOM   456  C  CG  . PHE A 1 57  ? -9.63240  -5.39524  15.46414  1.000 17.31298 ? 57  PHE A CG  1 
ATOM   457  C  CD1 . PHE A 1 57  ? -9.05800  -5.11073  16.68676  1.000 18.84139 ? 57  PHE A CD1 1 
ATOM   458  C  CD2 . PHE A 1 57  ? -9.08059  -4.82725  14.32571  1.000 17.95035 ? 57  PHE A CD2 1 
ATOM   459  C  CE1 . PHE A 1 57  ? -7.94667  -4.25503  16.76955  1.000 19.56640 ? 57  PHE A CE1 1 
ATOM   460  C  CE2 . PHE A 1 57  ? -7.98647  -3.98076  14.40536  1.000 17.79817 ? 57  PHE A CE2 1 
ATOM   461  C  CZ  . PHE A 1 57  ? -7.42966  -3.68443  15.62817  1.000 20.60811 ? 57  PHE A CZ  1 
ATOM   462  N  N   . LYS A 1 58  ? -13.95524 -6.68512  14.44497  1.000 14.80739 ? 58  LYS A N   1 
ATOM   463  C  CA  . LYS A 1 58  ? -14.92281 -7.68680  13.99722  1.000 16.68367 ? 58  LYS A CA  1 
ATOM   464  C  C   . LYS A 1 58  ? -14.70413 -7.95272  12.51979  1.000 11.52975 ? 58  LYS A C   1 
ATOM   465  O  O   . LYS A 1 58  ? -14.83057 -7.03540  11.70855  1.000 14.38531 ? 58  LYS A O   1 
ATOM   466  C  CB  . LYS A 1 58  ? -16.34673 -7.20009  14.24524  1.000 20.88577 ? 58  LYS A CB  1 
ATOM   467  C  CG  . LYS A 1 58  ? -17.39719 -8.11079  13.72373  1.000 23.36925 ? 58  LYS A CG  1 
ATOM   468  C  CD  . LYS A 1 58  ? -18.57884 -7.98469  14.62953  1.000 31.97054 ? 58  LYS A CD  1 
ATOM   469  C  CE  . LYS A 1 58  ? -19.83389 -8.43878  13.96496  1.000 44.50830 ? 58  LYS A CE  1 
ATOM   470  N  NZ  . LYS A 1 58  ? -20.90929 -8.42198  14.99703  1.000 57.26726 ? 58  LYS A NZ  1 
ATOM   471  N  N   . ARG A 1 59  ? -14.34920 -9.18786  12.16612  1.000 12.16156 ? 59  ARG A N   1 
ATOM   472  C  CA  . ARG A 1 59  ? -14.13010 -9.49622  10.75834  1.000 12.79817 ? 59  ARG A CA  1 
ATOM   473  C  C   . ARG A 1 59  ? -15.47681 -9.48279  10.04167  1.000 17.58961 ? 59  ARG A C   1 
ATOM   474  O  O   . ARG A 1 59  ? -16.46121 -10.05353 10.51892  1.000 17.01961 ? 59  ARG A O   1 
ATOM   475  C  CB  . ARG A 1 59  ? -13.42162 -10.84627 10.59392  1.000 18.06637 ? 59  ARG A CB  1 
ATOM   476  C  CG  . ARG A 1 59  ? -12.92992 -11.11151 9.16670   1.000 23.85514 ? 59  ARG A CG  1 
ATOM   477  C  CD  . ARG A 1 59  ? -12.34394 -12.53238 9.01497   1.000 32.36533 ? 59  ARG A CD  1 
ATOM   478  N  NE  . ARG A 1 59  ? -10.95359 -12.63703 9.45378   1.000 42.03973 ? 59  ARG A NE  1 
ATOM   479  C  CZ  . ARG A 1 59  ? -9.96552  -13.13112 8.71449   1.000 27.27757 ? 59  ARG A CZ  1 
ATOM   480  N  NH1 . ARG A 1 59  ? -10.17389 -13.57111 7.48685   1.000 28.57422 ? 59  ARG A NH1 1 
ATOM   481  N  NH2 . ARG A 1 59  ? -8.74313  -13.21539 9.23566   1.000 37.75606 ? 59  ARG A NH2 1 
ATOM   482  N  N   . LEU A 1 60  ? -15.54463 -8.78416  8.92320   1.000 13.05070 ? 60  LEU A N   1 
ATOM   483  C  CA  . LEU A 1 60  ? -16.75524 -8.66924  8.12036   1.000 8.91594  ? 60  LEU A CA  1 
ATOM   484  C  C   . LEU A 1 60  ? -16.86143 -9.81164  7.11883   1.000 11.68522 ? 60  LEU A C   1 
ATOM   485  O  O   . LEU A 1 60  ? -15.84669 -10.38740 6.73179   1.000 12.44051 ? 60  LEU A O   1 
ATOM   486  C  CB  . LEU A 1 60  ? -16.76144 -7.34374  7.36212   1.000 10.61121 ? 60  LEU A CB  1 
ATOM   487  C  CG  . LEU A 1 60  ? -16.75383 -6.12452  8.25001   1.000 11.38368 ? 60  LEU A CG  1 
ATOM   488  C  CD1 . LEU A 1 60  ? -16.41369 -4.90275  7.42056   1.000 12.04459 ? 60  LEU A CD1 1 
ATOM   489  C  CD2 . LEU A 1 60  ? -18.17048 -5.98256  8.85711   1.000 16.19699 ? 60  LEU A CD2 1 
ATOM   490  N  N   . PRO A 1 61  ? -18.09089 -10.15494 6.70431   1.000 14.43742 ? 61  PRO A N   1 
ATOM   491  C  CA  . PRO A 1 61  ? -18.27164 -11.20357 5.69180   1.000 15.09975 ? 61  PRO A CA  1 
ATOM   492  C  C   . PRO A 1 61  ? -17.41834 -10.92097 4.47033   1.000 15.03699 ? 61  PRO A C   1 
ATOM   493  O  O   . PRO A 1 61  ? -17.32567 -9.78601  4.00383   1.000 15.50608 ? 61  PRO A O   1 
ATOM   494  C  CB  . PRO A 1 61  ? -19.76638 -11.13574 5.36569   1.000 16.61154 ? 61  PRO A CB  1 
ATOM   495  C  CG  . PRO A 1 61  ? -20.38434 -10.66988 6.63373   1.000 15.95544 ? 61  PRO A CG  1 
ATOM   496  C  CD  . PRO A 1 61  ? -19.38257 -9.71130  7.26454   1.000 14.19242 ? 61  PRO A CD  1 
ATOM   497  N  N   . HIS A 1 62  ? -16.81123 -11.97774 3.95560   1.000 15.80435 ? 62  HIS A N   1 
ATOM   498  C  CA  . HIS A 1 62  ? -15.81580 -11.82810 2.91785   1.000 11.34329 ? 62  HIS A CA  1 
ATOM   499  C  C   . HIS A 1 62  ? -16.44341 -11.36725 1.61040   1.000 14.01424 ? 62  HIS A C   1 
ATOM   500  O  O   . HIS A 1 62  ? -17.40701 -11.96906 1.10650   1.000 14.13207 ? 62  HIS A O   1 
ATOM   501  C  CB  . HIS A 1 62  ? -15.07532 -13.14327 2.73173   1.000 15.61959 ? 62  HIS A CB  1 
ATOM   502  C  CG  . HIS A 1 62  ? -13.86333 -13.01283 1.87035   1.000 13.66103 ? 62  HIS A CG  1 
ATOM   503  N  ND1 . HIS A 1 62  ? -12.71338 -12.37256 2.29479   1.000 15.31548 ? 62  HIS A ND1 1 
ATOM   504  C  CD2 . HIS A 1 62  ? -13.62435 -13.42208 0.60384   1.000 16.13046 ? 62  HIS A CD2 1 
ATOM   505  C  CE1 . HIS A 1 62  ? -11.81193 -12.41626 1.33209   1.000 13.39433 ? 62  HIS A CE1 1 
ATOM   506  N  NE2 . HIS A 1 62  ? -12.33585 -13.05063 0.29603   1.000 18.33684 ? 62  HIS A NE2 1 
ATOM   507  N  N   . ARG A 1 63  ? -15.87579 -10.28978 1.05012   1.000 10.43588 ? 63  ARG A N   1 
ATOM   508  C  CA  . ARG A 1 63  ? -16.32700 -9.69712  -0.20275  1.000 12.03169 ? 63  ARG A CA  1 
ATOM   509  C  C   . ARG A 1 63  ? -15.13362 -9.40727  -1.10153  1.000 9.44978  ? 63  ARG A C   1 
ATOM   510  O  O   . ARG A 1 63  ? -14.00413 -9.20805  -0.62054  1.000 13.04322 ? 63  ARG A O   1 
ATOM   511  C  CB  . ARG A 1 63  ? -17.09926 -8.37466  0.02865   1.000 14.74830 ? 63  ARG A CB  1 
ATOM   512  C  CG  . ARG A 1 63  ? -18.39141 -8.53466  0.84123   1.000 15.45591 ? 63  ARG A CG  1 
ATOM   513  C  CD  . ARG A 1 63  ? -19.05771 -7.18434  1.01548   1.000 14.60317 ? 63  ARG A CD  1 
ATOM   514  N  NE  . ARG A 1 63  ? -19.56103 -6.61286  -0.23385  1.000 15.51395 ? 63  ARG A NE  1 
ATOM   515  C  CZ  . ARG A 1 63  ? -20.80178 -6.75745  -0.68331  1.000 22.24478 ? 63  ARG A CZ  1 
ATOM   516  N  NH1 . ARG A 1 63  ? -21.66306 -7.57361  -0.08959  1.000 21.41869 ? 63  ARG A NH1 1 
ATOM   517  N  NH2 . ARG A 1 63  ? -21.19274 -6.06684  -1.75903  1.000 19.70491 ? 63  ARG A NH2 1 
ATOM   518  N  N   . ASP A 1 64  ? -15.40219 -9.38300  -2.41199  1.000 11.28236 ? 64  ASP A N   1 
ATOM   519  C  CA  . ASP A 1 64  ? -14.38827 -8.96823  -3.38517  1.000 11.77888 ? 64  ASP A CA  1 
ATOM   520  C  C   . ASP A 1 64  ? -13.89618 -7.56705  -3.04993  1.000 9.68963  ? 64  ASP A C   1 
ATOM   521  O  O   . ASP A 1 64  ? -14.64888 -6.71725  -2.55754  1.000 11.77921 ? 64  ASP A O   1 
ATOM   522  C  CB  . ASP A 1 64  ? -14.94561 -8.93801  -4.80543  1.000 12.62822 ? 64  ASP A CB  1 
ATOM   523  C  CG  . ASP A 1 64  ? -15.50097 -10.26042 -5.27803  1.000 19.70676 ? 64  ASP A CG  1 
ATOM   524  O  OD1 . ASP A 1 64  ? -15.10928 -11.33180 -4.73890  1.000 17.93309 ? 64  ASP A OD1 1 
ATOM   525  O  OD2 . ASP A 1 64  ? -16.31131 -10.19018 -6.25565  1.000 20.11091 ? 64  ASP A OD2 1 
ATOM   526  N  N   . TYR A 1 65  ? -12.62281 -7.31629  -3.32842  1.000 9.40705  ? 65  TYR A N   1 
ATOM   527  C  CA  . TYR A 1 65  ? -12.05771 -5.98167  -3.15081  1.000 7.32605  ? 65  TYR A CA  1 
ATOM   528  C  C   . TYR A 1 65  ? -12.42802 -5.12979  -4.35171  1.000 10.55811 ? 65  TYR A C   1 
ATOM   529  O  O   . TYR A 1 65  ? -12.27962 -5.56481  -5.49439  1.000 9.85514  ? 65  TYR A O   1 
ATOM   530  C  CB  . TYR A 1 65  ? -10.54040 -6.05355  -3.01815  1.000 9.35882  ? 65  TYR A CB  1 
ATOM   531  C  CG  . TYR A 1 65  ? -9.86738  -4.70319  -2.95725  1.000 8.28381  ? 65  TYR A CG  1 
ATOM   532  C  CD1 . TYR A 1 65  ? -10.22206 -3.75510  -2.00480  1.000 8.52971  ? 65  TYR A CD1 1 
ATOM   533  C  CD2 . TYR A 1 65  ? -8.82335  -4.39133  -3.82677  1.000 10.26167 ? 65  TYR A CD2 1 
ATOM   534  C  CE1 . TYR A 1 65  ? -9.59262  -2.49364  -1.94323  1.000 8.27425  ? 65  TYR A CE1 1 
ATOM   535  C  CE2 . TYR A 1 65  ? -8.17905  -3.13921  -3.76070  1.000 9.49432  ? 65  TYR A CE2 1 
ATOM   536  C  CZ  . TYR A 1 65  ? -8.57278  -2.20543  -2.82117  1.000 8.81886  ? 65  TYR A CZ  1 
ATOM   537  O  OH  . TYR A 1 65  ? -7.91919  -0.99618  -2.81138  1.000 12.17073 ? 65  TYR A OH  1 
ATOM   538  N  N   . THR A 1 66  ? -12.88510 -3.90857  -4.10007  1.000 8.18117  ? 66  THR A N   1 
ATOM   539  C  CA  . THR A 1 66  ? -13.16770 -2.96151  -5.17729  1.000 9.64240  ? 66  THR A CA  1 
ATOM   540  C  C   . THR A 1 66  ? -12.58185 -1.60874  -4.79452  1.000 9.10677  ? 66  THR A C   1 
ATOM   541  O  O   . THR A 1 66  ? -12.72415 -1.14709  -3.65060  1.000 10.99038 ? 66  THR A O   1 
ATOM   542  C  CB  . THR A 1 66  ? -14.67980 -2.82326  -5.47457  1.000 9.73770  ? 66  THR A CB  1 
ATOM   543  O  OG1 . THR A 1 66  ? -15.34854 -2.40302  -4.27305  1.000 13.24575 ? 66  THR A OG1 1 
ATOM   544  C  CG2 . THR A 1 66  ? -15.27496 -4.15695  -5.91597  1.000 11.87207 ? 66  THR A CG2 1 
ATOM   545  N  N   . THR A 1 67  ? -11.86275 -0.99078  -5.73622  1.000 8.73418  ? 67  THR A N   1 
ATOM   546  C  CA  . THR A 1 67  ? -11.41659 0.38078   -5.53123  1.000 9.19889  ? 67  THR A CA  1 
ATOM   547  C  C   . THR A 1 67  ? -11.72254 1.19499   -6.79126  1.000 8.24744  ? 67  THR A C   1 
ATOM   548  O  O   . THR A 1 67  ? -12.27223 0.68151   -7.76477  1.000 9.82776  ? 67  THR A O   1 
ATOM   549  C  CB  . THR A 1 67  ? -9.92989  0.44872   -5.14590  1.000 9.66815  ? 67  THR A CB  1 
ATOM   550  O  OG1 . THR A 1 67  ? -9.58853  1.81207   -4.88810  1.000 11.04236 ? 67  THR A OG1 1 
ATOM   551  C  CG2 . THR A 1 67  ? -9.00728  -0.07410  -6.25762  1.000 11.15372 ? 67  THR A CG2 1 
ATOM   552  N  N   . TYR A 1 68  ? -11.43826 2.49129   -6.72598  1.000 10.39207 ? 68  TYR A N   1 
ATOM   553  C  CA  . TYR A 1 68  ? -11.79945 3.42694   -7.78960  1.000 9.17189  ? 68  TYR A CA  1 
ATOM   554  C  C   . TYR A 1 68  ? -10.63518 3.64036   -8.73360  1.000 12.66120 ? 68  TYR A C   1 
ATOM   555  O  O   . TYR A 1 68  ? -9.50467  3.82536   -8.27710  1.000 11.60594 ? 68  TYR A O   1 
ATOM   556  C  CB  . TYR A 1 68  ? -12.16448 4.80062   -7.23298  1.000 11.78183 ? 68  TYR A CB  1 
ATOM   557  C  CG  . TYR A 1 68  ? -13.36576 4.86903   -6.32414  1.000 11.79945 ? 68  TYR A CG  1 
ATOM   558  C  CD1 . TYR A 1 68  ? -13.27536 4.49859   -4.97029  1.000 11.34359 ? 68  TYR A CD1 1 
ATOM   559  C  CD2 . TYR A 1 68  ? -14.57012 5.36090   -6.79620  1.000 13.21248 ? 68  TYR A CD2 1 
ATOM   560  C  CE1 . TYR A 1 68  ? -14.37296 4.58529   -4.13543  1.000 15.50503 ? 68  TYR A CE1 1 
ATOM   561  C  CE2 . TYR A 1 68  ? -15.67168 5.47652   -5.96077  1.000 13.10110 ? 68  TYR A CE2 1 
ATOM   562  C  CZ  . TYR A 1 68  ? -15.56311 5.08536   -4.64010  1.000 15.64640 ? 68  TYR A CZ  1 
ATOM   563  O  OH  . TYR A 1 68  ? -16.68281 5.20024   -3.84133  1.000 17.14924 ? 68  TYR A OH  1 
ATOM   564  N  N   . LYS A 1 69  ? -10.94487 3.76280   -10.03590 1.000 11.69186 ? 69  LYS A N   1 
ATOM   565  C  CA  . LYS A 1 69  ? -9.89792  4.09922   -10.99416 1.000 11.77412 ? 69  LYS A CA  1 
ATOM   566  C  C   . LYS A 1 69  ? -9.26757  5.45239   -10.69720 1.000 13.83425 ? 69  LYS A C   1 
ATOM   567  O  O   . LYS A 1 69  ? -8.08116  5.65618   -10.97284 1.000 12.24230 ? 69  LYS A O   1 
ATOM   568  C  CB  . LYS A 1 69  ? -10.44623 4.07235   -12.42108 1.000 10.52857 ? 69  LYS A CB  1 
ATOM   569  C  CG  . LYS A 1 69  ? -10.69506 2.67063   -12.91701 1.000 18.01523 ? 69  LYS A CG  1 
ATOM   570  C  CD  . LYS A 1 69  ? -10.90448 2.67074   -14.42348 1.000 22.91007 ? 69  LYS A CD  1 
ATOM   571  C  CE  . LYS A 1 69  ? -11.17908 1.26832   -14.95526 1.000 32.40065 ? 69  LYS A CE  1 
ATOM   572  N  NZ  . LYS A 1 69  ? -10.95561 1.16184   -16.43745 1.000 39.76757 ? 69  LYS A NZ  1 
ATOM   573  N  N   . LYS A 1 70  ? -10.01726 6.36804   -10.08806 1.000 12.46860 ? 70  LYS A N   1 
ATOM   574  C  CA  . LYS A 1 70  ? -9.46424  7.68207   -9.80516  1.000 16.70003 ? 70  LYS A CA  1 
ATOM   575  C  C   . LYS A 1 70  ? -8.35456  7.64323   -8.76484  1.000 17.16725 ? 70  LYS A C   1 
ATOM   576  O  O   . LYS A 1 70  ? -7.57669  8.59434   -8.69505  1.000 18.84308 ? 70  LYS A O   1 
ATOM   577  C  CB  . LYS A 1 70  ? -10.56756 8.63643   -9.37166  1.000 16.09224 ? 70  LYS A CB  1 
ATOM   578  C  CG  . LYS A 1 70  ? -11.12622 8.37379   -8.01525  1.000 17.76098 ? 70  LYS A CG  1 
ATOM   579  C  CD  . LYS A 1 70  ? -12.28765 9.29181   -7.72099  1.000 21.43047 ? 70  LYS A CD  1 
ATOM   580  C  CE  . LYS A 1 70  ? -12.81123 9.02708   -6.31822  1.000 28.22614 ? 70  LYS A CE  1 
ATOM   581  N  NZ  . LYS A 1 70  ? -14.15538 9.61627   -6.08467  1.000 36.53726 ? 70  LYS A NZ  1 
ATOM   582  N  N   . PHE A 1 71  ? -8.27196  6.59022   -7.93954  1.000 10.92532 ? 71  PHE A N   1 
ATOM   583  C  CA  . PHE A 1 71  ? -7.14890  6.41801   -7.02259  1.000 13.42374 ? 71  PHE A CA  1 
ATOM   584  C  C   . PHE A 1 71  ? -6.13179  5.41765   -7.54227  1.000 13.99293 ? 71  PHE A C   1 
ATOM   585  O  O   . PHE A 1 71  ? -4.92642  5.60304   -7.35002  1.000 15.30095 ? 71  PHE A O   1 
ATOM   586  C  CB  . PHE A 1 71  ? -7.64081  5.95390   -5.65103  1.000 13.85211 ? 71  PHE A CB  1 
ATOM   587  C  CG  . PHE A 1 71  ? -8.61746  6.89630   -5.01776  1.000 14.43860 ? 71  PHE A CG  1 
ATOM   588  C  CD1 . PHE A 1 71  ? -8.25236  8.20211   -4.73002  1.000 15.46834 ? 71  PHE A CD1 1 
ATOM   589  C  CD2 . PHE A 1 71  ? -9.89432  6.47066   -4.71135  1.000 16.23751 ? 71  PHE A CD2 1 
ATOM   590  C  CE1 . PHE A 1 71  ? -9.15626  9.05994   -4.14479  1.000 16.63300 ? 71  PHE A CE1 1 
ATOM   591  C  CE2 . PHE A 1 71  ? -10.80389 7.33065   -4.11521  1.000 16.31239 ? 71  PHE A CE2 1 
ATOM   592  C  CZ  . PHE A 1 71  ? -10.42220 8.62447   -3.85350  1.000 17.34138 ? 71  PHE A CZ  1 
ATOM   593  N  N   . ASN A 1 72  ? -6.60023  4.37495   -8.21784  1.000 12.23014 ? 72  ASN A N   1 
ATOM   594  C  CA  . ASN A 1 72  ? -5.75703  3.27095   -8.66587  1.000 10.75267 ? 72  ASN A CA  1 
ATOM   595  C  C   . ASN A 1 72  ? -6.11587  2.98936   -10.11708 1.000 14.29851 ? 72  ASN A C   1 
ATOM   596  O  O   . ASN A 1 72  ? -7.04723  2.22648   -10.40869 1.000 11.09222 ? 72  ASN A O   1 
ATOM   597  C  CB  . ASN A 1 72  ? -5.97221  2.03163   -7.79708  1.000 13.91558 ? 72  ASN A CB  1 
ATOM   598  C  CG  . ASN A 1 72  ? -5.08486  0.87480   -8.20724  1.000 14.57550 ? 72  ASN A CG  1 
ATOM   599  O  OD1 . ASN A 1 72  ? -4.49316  0.86907   -9.28972  1.000 13.81259 ? 72  ASN A OD1 1 
ATOM   600  N  ND2 . ASN A 1 72  ? -4.97422  -0.11557  -7.32459  1.000 15.17849 ? 72  ASN A ND2 1 
ATOM   601  N  N   . PRO A 1 73  ? -5.38833  3.58170   -11.06318 1.000 11.47828 ? 73  PRO A N   1 
ATOM   602  C  CA  . PRO A 1 73  ? -5.76651  3.41634   -12.47579 1.000 13.13311 ? 73  PRO A CA  1 
ATOM   603  C  C   . PRO A 1 73  ? -5.46329  2.03649   -13.02325 1.000 15.56293 ? 73  PRO A C   1 
ATOM   604  O  O   . PRO A 1 73  ? -6.01773  1.66678   -14.05380 1.000 19.60217 ? 73  PRO A O   1 
ATOM   605  C  CB  . PRO A 1 73  ? -4.94164  4.49256   -13.19249 1.000 18.14023 ? 73  PRO A CB  1 
ATOM   606  C  CG  . PRO A 1 73  ? -3.74495  4.73715   -12.27302 1.000 25.41519 ? 73  PRO A CG  1 
ATOM   607  C  CD  . PRO A 1 73  ? -4.24622  4.49027   -10.86115 1.000 19.45710 ? 73  PRO A CD  1 
ATOM   608  N  N   A VAL A 1 74  ? -4.60599  1.26637   -12.36886 0.486 13.31921 ? 74  VAL A N   1 
ATOM   609  N  N   B VAL A 1 74  ? -4.60395  1.24606   -12.37911 0.514 13.31954 ? 74  VAL A N   1 
ATOM   610  C  CA  A VAL A 1 74  ? -4.25910  -0.05801  -12.87158 0.486 13.10077 ? 74  VAL A CA  1 
ATOM   611  C  CA  B VAL A 1 74  ? -4.26741  -0.07235  -12.91753 0.514 13.06359 ? 74  VAL A CA  1 
ATOM   612  C  C   A VAL A 1 74  ? -5.19540  -1.11996  -12.31666 0.486 14.70113 ? 74  VAL A C   1 
ATOM   613  C  C   B VAL A 1 74  ? -5.03119  -1.20548  -12.24475 0.514 14.54009 ? 74  VAL A C   1 
ATOM   614  O  O   A VAL A 1 74  ? -5.57903  -2.05616  -13.02782 0.486 15.67550 ? 74  VAL A O   1 
ATOM   615  O  O   B VAL A 1 74  ? -5.11744  -2.30202  -12.82452 0.514 15.20441 ? 74  VAL A O   1 
ATOM   616  C  CB  A VAL A 1 74  ? -2.78647  -0.36763  -12.52301 0.486 13.13033 ? 74  VAL A CB  1 
ATOM   617  C  CB  B VAL A 1 74  ? -2.74941  -0.35945  -12.83393 0.514 13.52063 ? 74  VAL A CB  1 
ATOM   618  C  CG1 A VAL A 1 74  ? -2.47325  -1.79812  -12.81082 0.486 11.85593 ? 74  VAL A CG1 1 
ATOM   619  C  CG1 B VAL A 1 74  ? -1.97482  0.61492   -13.71961 0.514 17.95286 ? 74  VAL A CG1 1 
ATOM   620  C  CG2 A VAL A 1 74  ? -1.84201  0.56307   -13.29367 0.486 17.89567 ? 74  VAL A CG2 1 
ATOM   621  C  CG2 B VAL A 1 74  ? -2.25387  -0.28645  -11.40349 0.514 12.76012 ? 74  VAL A CG2 1 
ATOM   622  N  N   . GLY A 1 75  ? -5.58745  -0.98251  -11.05205 1.000 10.35716 ? 75  GLY A N   1 
ATOM   623  C  CA  . GLY A 1 75  ? -6.34616  -2.02192  -10.38071 1.000 13.11890 ? 75  GLY A CA  1 
ATOM   624  C  C   . GLY A 1 75  ? -7.71396  -1.59055  -9.90758  1.000 11.34765 ? 75  GLY A C   1 
ATOM   625  O  O   . GLY A 1 75  ? -8.35560  -2.31488  -9.14421  1.000 10.12919 ? 75  GLY A O   1 
ATOM   626  N  N   . GLY A 1 76  ? -8.17845  -0.42734  -10.37133 1.000 9.48349  ? 76  GLY A N   1 
ATOM   627  C  CA  . GLY A 1 76  ? -9.47795  0.08881   -9.98084  1.000 7.70900  ? 76  GLY A CA  1 
ATOM   628  C  C   . GLY A 1 76  ? -10.58008 -0.27875  -10.95637 1.000 9.06555  ? 76  GLY A C   1 
ATOM   629  O  O   . GLY A 1 76  ? -10.33847 -0.69273  -12.09804 1.000 12.17230 ? 76  GLY A O   1 
ATOM   630  N  N   . GLY A 1 77  ? -11.80924 -0.08630  -10.49508 1.000 11.19869 ? 77  GLY A N   1 
ATOM   631  C  CA  . GLY A 1 77  ? -12.94964 -0.27897  -11.36571 1.000 10.41764 ? 77  GLY A CA  1 
ATOM   632  C  C   . GLY A 1 77  ? -13.32120 -1.71528  -11.63276 1.000 10.99844 ? 77  GLY A C   1 
ATOM   633  O  O   . GLY A 1 77  ? -14.15524 -1.96459  -12.51393 1.000 16.90454 ? 77  GLY A O   1 
ATOM   634  N  N   . ILE A 1 78  ? -12.76137 -2.67661  -10.90310 1.000 9.13649  ? 78  ILE A N   1 
ATOM   635  C  CA  . ILE A 1 78  ? -13.04100 -4.08370  -11.15236 1.000 11.97982 ? 78  ILE A CA  1 
ATOM   636  C  C   . ILE A 1 78  ? -13.21744 -4.85380  -9.84157  1.000 9.91278  ? 78  ILE A C   1 
ATOM   637  O  O   . ILE A 1 78  ? -12.65712 -4.50101  -8.79560  1.000 11.80336 ? 78  ILE A O   1 
ATOM   638  C  CB  . ILE A 1 78  ? -11.92112 -4.73369  -12.00226 1.000 12.35259 ? 78  ILE A CB  1 
ATOM   639  C  CG1 . ILE A 1 78  ? -10.54815 -4.51839  -11.35472 1.000 12.80874 ? 78  ILE A CG1 1 
ATOM   640  C  CG2 . ILE A 1 78  ? -11.92801 -4.15527  -13.43424 1.000 17.65332 ? 78  ILE A CG2 1 
ATOM   641  C  CD1 . ILE A 1 78  ? -9.43341  -5.36114  -12.01943 1.000 18.33661 ? 78  ILE A CD1 1 
ATOM   642  N  N   A ARG A 1 79  ? -13.98445 -5.93714  -9.90583  0.495 11.31700 ? 79  ARG A N   1 
ATOM   643  N  N   B ARG A 1 79  ? -13.95118 -5.95886  -9.92516  0.505 11.28280 ? 79  ARG A N   1 
ATOM   644  C  CA  A ARG A 1 79  ? -14.10845 -6.83063  -8.75655  0.495 11.95607 ? 79  ARG A CA  1 
ATOM   645  C  CA  B ARG A 1 79  ? -14.10374 -6.85689  -8.78203  0.505 11.95700 ? 79  ARG A CA  1 
ATOM   646  C  C   A ARG A 1 79  ? -12.86527 -7.70971  -8.67267  0.495 12.18267 ? 79  ARG A C   1 
ATOM   647  C  C   B ARG A 1 79  ? -12.87699 -7.75330  -8.66167  0.505 12.17950 ? 79  ARG A C   1 
ATOM   648  O  O   A ARG A 1 79  ? -12.54236 -8.42702  -9.62602  0.495 15.45445 ? 79  ARG A O   1 
ATOM   649  O  O   B ARG A 1 79  ? -12.58920 -8.54270  -9.56822  0.505 15.48147 ? 79  ARG A O   1 
ATOM   650  C  CB  A ARG A 1 79  ? -15.36901 -7.68711  -8.87020  0.495 15.69016 ? 79  ARG A CB  1 
ATOM   651  C  CB  B ARG A 1 79  ? -15.36618 -7.70174  -8.93675  0.505 15.67021 ? 79  ARG A CB  1 
ATOM   652  C  CG  A ARG A 1 79  ? -16.65744 -6.96391  -8.47663  0.495 17.57855 ? 79  ARG A CG  1 
ATOM   653  C  CG  B ARG A 1 79  ? -16.64458 -6.90601  -8.73423  0.505 17.84297 ? 79  ARG A CG  1 
ATOM   654  C  CD  A ARG A 1 79  ? -17.87434 -7.90127  -8.58160  0.495 21.78083 ? 79  ARG A CD  1 
ATOM   655  C  CD  B ARG A 1 79  ? -17.89567 -7.79292  -8.71411  0.505 21.89554 ? 79  ARG A CD  1 
ATOM   656  N  NE  A ARG A 1 79  ? -19.09879 -7.25054  -8.12323  0.495 25.41095 ? 79  ARG A NE  1 
ATOM   657  N  NE  B ARG A 1 79  ? -18.96513 -7.11553  -7.99067  0.505 25.54456 ? 79  ARG A NE  1 
ATOM   658  C  CZ  A ARG A 1 79  ? -19.93714 -6.58054  -8.90121  0.495 28.97840 ? 79  ARG A CZ  1 
ATOM   659  C  CZ  B ARG A 1 79  ? -19.05648 -7.10889  -6.66960  0.505 20.56953 ? 79  ARG A CZ  1 
ATOM   660  N  NH1 A ARG A 1 79  ? -19.73885 -6.47378  -10.20650 0.495 26.94025 ? 79  ARG A NH1 1 
ATOM   661  N  NH1 B ARG A 1 79  ? -18.22126 -7.80871  -5.91935  0.505 19.78810 ? 79  ARG A NH1 1 
ATOM   662  N  NH2 A ARG A 1 79  ? -21.00330 -6.00357  -8.35661  0.495 24.83997 ? 79  ARG A NH2 1 
ATOM   663  N  NH2 B ARG A 1 79  ? -19.99858 -6.37379  -6.08772  0.505 23.04038 ? 79  ARG A NH2 1 
ATOM   664  N  N   . ARG A 1 80  ? -12.15565 -7.64803  -7.53916  1.000 8.66052  ? 80  ARG A N   1 
ATOM   665  C  CA  . ARG A 1 80  ? -10.91228 -8.39058  -7.34541  1.000 8.26620  ? 80  ARG A CA  1 
ATOM   666  C  C   . ARG A 1 80  ? -11.15579 -9.47351  -6.30730  1.000 11.30000 ? 80  ARG A C   1 
ATOM   667  O  O   . ARG A 1 80  ? -11.34705 -9.17687  -5.11967  1.000 11.71584 ? 80  ARG A O   1 
ATOM   668  C  CB  . ARG A 1 80  ? -9.77800  -7.44535  -6.93677  1.000 8.58467  ? 80  ARG A CB  1 
ATOM   669  C  CG  . ARG A 1 80  ? -9.34894  -6.61064  -8.14449  1.000 7.67246  ? 80  ARG A CG  1 
ATOM   670  C  CD  . ARG A 1 80  ? -8.59548  -5.35331  -7.78875  1.000 8.62887  ? 80  ARG A CD  1 
ATOM   671  N  NE  . ARG A 1 80  ? -7.32668  -5.67892  -7.13930  1.000 10.26741 ? 80  ARG A NE  1 
ATOM   672  C  CZ  . ARG A 1 80  ? -6.51202  -4.75877  -6.63838  1.000 10.82095 ? 80  ARG A CZ  1 
ATOM   673  N  NH1 . ARG A 1 80  ? -6.70735  -3.46230  -6.86305  1.000 9.10940  ? 80  ARG A NH1 1 
ATOM   674  N  NH2 . ARG A 1 80  ? -5.48272  -5.13873  -5.88950  1.000 10.36082 ? 80  ARG A NH2 1 
ATOM   675  N  N   . VAL A 1 81  ? -11.15279 -10.73013 -6.76287  1.000 9.68204  ? 81  VAL A N   1 
ATOM   676  C  CA  . VAL A 1 81  ? -11.55546 -11.86921 -5.95091  1.000 13.02332 ? 81  VAL A CA  1 
ATOM   677  C  C   . VAL A 1 81  ? -10.30651 -12.39592 -5.25576  1.000 13.34668 ? 81  VAL A C   1 
ATOM   678  O  O   . VAL A 1 81  ? -9.41025  -12.94504 -5.91190  1.000 16.87393 ? 81  VAL A O   1 
ATOM   679  C  CB  . VAL A 1 81  ? -12.20983 -12.96066 -6.80268  1.000 14.51074 ? 81  VAL A CB  1 
ATOM   680  C  CG1 . VAL A 1 81  ? -12.64206 -14.11726 -5.90788  1.000 17.02423 ? 81  VAL A CG1 1 
ATOM   681  C  CG2 . VAL A 1 81  ? -13.41509 -12.40346 -7.53183  1.000 13.24216 ? 81  VAL A CG2 1 
ATOM   682  N  N   . TYR A 1 82  ? -10.23739 -12.22261 -3.92789  1.000 10.84020 ? 82  TYR A N   1 
ATOM   683  C  CA  . TYR A 1 82  ? -9.08272  -12.62498 -3.13208  1.000 12.35307 ? 82  TYR A CA  1 
ATOM   684  C  C   . TYR A 1 82  ? -9.52106  -13.60997 -2.05420  1.000 12.36455 ? 82  TYR A C   1 
ATOM   685  O  O   . TYR A 1 82  ? -10.68900 -13.63605 -1.63942  1.000 18.46934 ? 82  TYR A O   1 
ATOM   686  C  CB  . TYR A 1 82  ? -8.40650  -11.41326 -2.46979  1.000 8.98002  ? 82  TYR A CB  1 
ATOM   687  C  CG  . TYR A 1 82  ? -7.69840  -10.52493 -3.44434  1.000 9.35712  ? 82  TYR A CG  1 
ATOM   688  C  CD1 . TYR A 1 82  ? -6.75614  -11.03878 -4.35202  1.000 10.96468 ? 82  TYR A CD1 1 
ATOM   689  C  CD2 . TYR A 1 82  ? -7.98885  -9.17438  -3.49749  1.000 10.47108 ? 82  TYR A CD2 1 
ATOM   690  C  CE1 . TYR A 1 82  ? -6.10500  -10.20378 -5.28726  1.000 7.49234  ? 82  TYR A CE1 1 
ATOM   691  C  CE2 . TYR A 1 82  ? -7.33016  -8.32946  -4.43273  1.000 8.92334  ? 82  TYR A CE2 1 
ATOM   692  C  CZ  . TYR A 1 82  ? -6.41241  -8.86134  -5.30796  1.000 8.09557  ? 82  TYR A CZ  1 
ATOM   693  O  OH  . TYR A 1 82  ? -5.81576  -8.03725  -6.21282  1.000 9.77028  ? 82  TYR A OH  1 
ATOM   694  N  N   . GLU A 1 83  ? -8.59214  -14.41669 -1.62900  1.000 10.36742 ? 83  GLU A N   1 
ATOM   695  C  CA  . GLU A 1 83  ? -8.84597  -15.29084 -0.49945  1.000 11.68280 ? 83  GLU A CA  1 
ATOM   696  C  C   . GLU A 1 83  ? -8.69044  -14.51707 0.80093   1.000 10.76547 ? 83  GLU A C   1 
ATOM   697  O  O   . GLU A 1 83  ? -7.86548  -13.59767 0.88871   1.000 11.15535 ? 83  GLU A O   1 
ATOM   698  C  CB  . GLU A 1 83  ? -7.88231  -16.47005 -0.49743  1.000 15.53735 ? 83  GLU A CB  1 
ATOM   699  C  CG  . GLU A 1 83  ? -8.11111  -17.43599 -1.65903  1.000 23.46114 ? 83  GLU A CG  1 
ATOM   700  C  CD  . GLU A 1 83  ? -9.32553  -18.31282 -1.44045  1.000 37.34726 ? 83  GLU A CD  1 
ATOM   701  O  OE1 . GLU A 1 83  ? -9.33488  -19.08779 -0.45429  1.000 45.40792 ? 83  GLU A OE1 1 
ATOM   702  O  OE2 . GLU A 1 83  ? -10.27425 -18.21998 -2.24749  1.000 42.71666 ? 83  GLU A OE2 1 
ATOM   703  N  N   . PRO A 1 84  ? -9.41216  -14.92083 1.84501   1.000 10.50497 ? 84  PRO A N   1 
ATOM   704  C  CA  . PRO A 1 84  ? -9.26676  -14.26815 3.15460   1.000 12.26082 ? 84  PRO A CA  1 
ATOM   705  C  C   . PRO A 1 84  ? -7.90886  -14.49854 3.80816   1.000 10.48824 ? 84  PRO A C   1 
ATOM   706  O  O   . PRO A 1 84  ? -7.22611  -15.50299 3.58653   1.000 12.37259 ? 84  PRO A O   1 
ATOM   707  C  CB  . PRO A 1 84  ? -10.38312 -14.90181 3.99602   1.000 14.82717 ? 84  PRO A CB  1 
ATOM   708  C  CG  . PRO A 1 84  ? -10.61602 -16.18285 3.36321   1.000 19.21999 ? 84  PRO A CG  1 
ATOM   709  C  CD  . PRO A 1 84  ? -10.39225 -16.02224 1.89182   1.000 14.82759 ? 84  PRO A CD  1 
ATOM   710  N  N   . ILE A 1 85  ? -7.55051  -13.54628 4.66374   1.000 10.48974 ? 85  ILE A N   1 
ATOM   711  C  CA  . ILE A 1 85  ? -6.38059  -13.66756 5.52465   1.000 10.80687 ? 85  ILE A CA  1 
ATOM   712  C  C   . ILE A 1 85  ? -6.62425  -14.75475 6.56357   1.000 13.21434 ? 85  ILE A C   1 
ATOM   713  O  O   . ILE A 1 85  ? -7.71195  -14.84244 7.15159   1.000 17.36687 ? 85  ILE A O   1 
ATOM   714  C  CB  . ILE A 1 85  ? -6.07757  -12.30749 6.17808   1.000 9.94467  ? 85  ILE A CB  1 
ATOM   715  C  CG1 . ILE A 1 85  ? -5.57461  -11.31802 5.10431   1.000 9.93955  ? 85  ILE A CG1 1 
ATOM   716  C  CG2 . ILE A 1 85  ? -5.02376  -12.44057 7.29565   1.000 14.21369 ? 85  ILE A CG2 1 
ATOM   717  C  CD1 . ILE A 1 85  ? -5.35396  -9.91098  5.63363   1.000 9.67664  ? 85  ILE A CD1 1 
ATOM   718  N  N   . GLU A 1 86  ? -5.61972  -15.61212 6.76245   1.000 13.11854 ? 86  GLU A N   1 
ATOM   719  C  CA  . GLU A 1 86  ? -5.77346  -16.73985 7.68916   1.000 15.32293 ? 86  GLU A CA  1 
ATOM   720  C  C   . GLU A 1 86  ? -5.31626  -16.40979 9.09190   1.000 19.84597 ? 86  GLU A C   1 
ATOM   721  O  O   . GLU A 1 86  ? -5.82224  -16.99506 10.05469  1.000 25.23115 ? 86  GLU A O   1 
ATOM   722  C  CB  . GLU A 1 86  ? -4.98281  -17.95477 7.20802   1.000 18.00985 ? 86  GLU A CB  1 
ATOM   723  C  CG  . GLU A 1 86  ? -5.27278  -18.39968 5.77755   1.000 22.19523 ? 86  GLU A CG  1 
ATOM   724  C  CD  . GLU A 1 86  ? -4.50621  -19.67082 5.40089   1.000 31.71667 ? 86  GLU A CD  1 
ATOM   725  O  OE1 . GLU A 1 86  ? -3.24756  -19.65476 5.34515   1.000 24.93622 ? 86  GLU A OE1 1 
ATOM   726  O  OE2 . GLU A 1 86  ? -5.17086  -20.70654 5.18076   1.000 41.58545 ? 86  GLU A OE2 1 
ATOM   727  N  N   . VAL A 1 87  ? -4.36108  -15.50057 9.23070   1.000 13.86583 ? 87  VAL A N   1 
ATOM   728  C  CA  . VAL A 1 87  ? -3.77020  -15.17611 10.51650  1.000 17.27166 ? 87  VAL A CA  1 
ATOM   729  C  C   . VAL A 1 87  ? -4.41391  -13.91370 11.07981  1.000 19.02282 ? 87  VAL A C   1 
ATOM   730  O  O   . VAL A 1 87  ? -5.29934  -13.31859 10.45192  1.000 18.56670 ? 87  VAL A O   1 
ATOM   731  C  CB  . VAL A 1 87  ? -2.24669  -15.01253 10.39519  1.000 15.66117 ? 87  VAL A CB  1 
ATOM   732  C  CG1 . VAL A 1 87  ? -1.58868  -16.33730 10.00992  1.000 17.87553 ? 87  VAL A CG1 1 
ATOM   733  C  CG2 . VAL A 1 87  ? -1.90831  -13.90230 9.36910   1.000 18.09063 ? 87  VAL A CG2 1 
ATOM   734  N  N   . ASP A 1 88  ? -3.97335  -13.50051 12.27257  1.000 18.68681 ? 88  ASP A N   1 
ATOM   735  C  CA  . ASP A 1 88  ? -4.59089  -12.39840 13.02172  1.000 15.24299 ? 88  ASP A CA  1 
ATOM   736  C  C   . ASP A 1 88  ? -3.62005  -11.23072 13.08416  1.000 17.05049 ? 88  ASP A C   1 
ATOM   737  O  O   . ASP A 1 88  ? -2.67083  -11.23509 13.88269  1.000 14.75235 ? 88  ASP A O   1 
ATOM   738  C  CB  . ASP A 1 88  ? -4.95613  -12.85198 14.43728  1.000 20.53598 ? 88  ASP A CB  1 
ATOM   739  C  CG  . ASP A 1 88  ? -5.62022  -11.75061 15.26949  1.000 21.28792 ? 88  ASP A CG  1 
ATOM   740  O  OD1 . ASP A 1 88  ? -5.93056  -10.66479 14.74860  1.000 20.46513 ? 88  ASP A OD1 1 
ATOM   741  O  OD2 . ASP A 1 88  ? -5.86386  -11.98554 16.47000  1.000 23.20707 ? 88  ASP A OD2 1 
ATOM   742  N  N   . PHE A 1 89  ? -3.85397  -10.22873 12.23797  1.000 14.35504 ? 89  PHE A N   1 
ATOM   743  C  CA  . PHE A 1 89  ? -3.02155  -9.04035  12.26642  1.000 11.97697 ? 89  PHE A CA  1 
ATOM   744  C  C   . PHE A 1 89  ? -3.52348  -8.00177  13.26584  1.000 12.33725 ? 89  PHE A C   1 
ATOM   745  O  O   . PHE A 1 89  ? -2.93061  -6.91269  13.36983  1.000 15.18586 ? 89  PHE A O   1 
ATOM   746  C  CB  . PHE A 1 89  ? -2.96773  -8.41893  10.84713  1.000 11.16308 ? 89  PHE A CB  1 
ATOM   747  C  CG  . PHE A 1 89  ? -2.08305  -9.14108  9.90850   1.000 10.92110 ? 89  PHE A CG  1 
ATOM   748  C  CD1 . PHE A 1 89  ? -0.69797  -9.07113  10.07825  1.000 16.36102 ? 89  PHE A CD1 1 
ATOM   749  C  CD2 . PHE A 1 89  ? -2.59193  -9.88243  8.83774   1.000 10.87694 ? 89  PHE A CD2 1 
ATOM   750  C  CE1 . PHE A 1 89  ? 0.15753   -9.72624  9.21768   1.000 15.94763 ? 89  PHE A CE1 1 
ATOM   751  C  CE2 . PHE A 1 89  ? -1.72285  -10.54670 7.95938   1.000 11.74041 ? 89  PHE A CE2 1 
ATOM   752  C  CZ  . PHE A 1 89  ? -0.35650  -10.45861 8.14583   1.000 14.32001 ? 89  PHE A CZ  1 
ATOM   753  N  N   . THR A 1 90  ? -4.59473  -8.30820  14.01927  1.000 15.81373 ? 90  THR A N   1 
ATOM   754  C  CA  . THR A 1 90  ? -5.16991  -7.20005  14.78255  1.000 14.77592 ? 90  THR A CA  1 
ATOM   755  C  C   . THR A 1 90  ? -4.26927  -6.72316  15.92833  1.000 17.88584 ? 90  THR A C   1 
ATOM   756  O  O   . THR A 1 90  ? -4.30407  -5.52104  16.22464  1.000 15.54670 ? 90  THR A O   1 
ATOM   757  C  CB  . THR A 1 90  ? -6.58861  -7.53208  15.26864  1.000 16.83783 ? 90  THR A CB  1 
ATOM   758  O  OG1 . THR A 1 90  ? -6.58787  -8.66646  16.14608  1.000 19.40870 ? 90  THR A OG1 1 
ATOM   759  C  CG2 . THR A 1 90  ? -7.49236  -7.85326  14.06659  1.000 15.00961 ? 90  THR A CG2 1 
ATOM   760  N  N   . PRO A 1 91  ? -3.41563  -7.56036  16.56434  1.000 18.45917 ? 91  PRO A N   1 
ATOM   761  C  CA  . PRO A 1 91  ? -2.42282  -6.98427  17.50227  1.000 20.18661 ? 91  PRO A CA  1 
ATOM   762  C  C   . PRO A 1 91  ? -1.48856  -5.95662  16.85681  1.000 18.82730 ? 91  PRO A C   1 
ATOM   763  O  O   . PRO A 1 91  ? -1.22608  -4.88690  17.42279  1.000 16.49179 ? 91  PRO A O   1 
ATOM   764  C  CB  . PRO A 1 91  ? -1.66094  -8.22447  18.00876  1.000 18.88971 ? 91  PRO A CB  1 
ATOM   765  C  CG  . PRO A 1 91  ? -2.62901  -9.32762  17.88854  1.000 17.47682 ? 91  PRO A CG  1 
ATOM   766  C  CD  . PRO A 1 91  ? -3.51743  -9.02868  16.71129  1.000 19.49881 ? 91  PRO A CD  1 
ATOM   767  N  N   . LEU A 1 92  ? -0.98650  -6.24724  15.66157  1.000 16.49748 ? 92  LEU A N   1 
ATOM   768  C  CA  . LEU A 1 92  ? -0.09369  -5.30586  14.99444  1.000 15.02022 ? 92  LEU A CA  1 
ATOM   769  C  C   . LEU A 1 92  ? -0.83884  -4.03238  14.63447  1.000 17.19956 ? 92  LEU A C   1 
ATOM   770  O  O   . LEU A 1 92  ? -0.30747  -2.91866  14.74885  1.000 15.52703 ? 92  LEU A O   1 
ATOM   771  C  CB  . LEU A 1 92  ? 0.48911   -5.98181  13.74651  1.000 19.42298 ? 92  LEU A CB  1 
ATOM   772  C  CG  . LEU A 1 92  ? 1.27947   -5.26725  12.65800  1.000 23.28100 ? 92  LEU A CG  1 
ATOM   773  C  CD1 . LEU A 1 92  ? 2.08562   -6.33157  11.91118  1.000 23.36680 ? 92  LEU A CD1 1 
ATOM   774  C  CD2 . LEU A 1 92  ? 0.38311   -4.54320  11.67663  1.000 23.69353 ? 92  LEU A CD2 1 
ATOM   775  N  N   . ILE A 1 93  ? -2.08016  -4.17858  14.19125  1.000 13.52664 ? 93  ILE A N   1 
ATOM   776  C  CA  . ILE A 1 93  ? -2.84910  -3.01710  13.77984  1.000 10.66582 ? 93  ILE A CA  1 
ATOM   777  C  C   . ILE A 1 93  ? -3.14518  -2.13088  14.97323  1.000 15.74061 ? 93  ILE A C   1 
ATOM   778  O  O   . ILE A 1 93  ? -3.16408  -0.90229  14.85711  1.000 16.28647 ? 93  ILE A O   1 
ATOM   779  C  CB  . ILE A 1 93  ? -4.12894  -3.50481  13.08832  1.000 11.64711 ? 93  ILE A CB  1 
ATOM   780  C  CG1 . ILE A 1 93  ? -3.80029  -4.30168  11.81800  1.000 14.38844 ? 93  ILE A CG1 1 
ATOM   781  C  CG2 . ILE A 1 93  ? -5.06210  -2.31239  12.77898  1.000 12.39712 ? 93  ILE A CG2 1 
ATOM   782  C  CD1 . ILE A 1 93  ? -5.06482  -4.92589  11.22238  1.000 13.05129 ? 93  ILE A CD1 1 
ATOM   783  N  N   . SER A 1 94  ? -3.34193  -2.73725  16.15003  1.000 14.53272 ? 94  SER A N   1 
ATOM   784  C  CA  . SER A 1 94  ? -3.58322  -1.94713  17.35054  1.000 17.88672 ? 94  SER A CA  1 
ATOM   785  C  C   . SER A 1 94  ? -2.41865  -1.02346  17.66238  1.000 20.07923 ? 94  SER A C   1 
ATOM   786  O  O   . SER A 1 94  ? -2.63045  0.05167   18.23693  1.000 18.30492 ? 94  SER A O   1 
ATOM   787  C  CB  . SER A 1 94  ? -3.83349  -2.86865  18.55275  1.000 17.75090 ? 94  SER A CB  1 
ATOM   788  O  OG  . SER A 1 94  ? -5.12583  -3.45688  18.48914  1.000 22.16307 ? 94  SER A OG  1 
ATOM   789  N  N   . GLU A 1 95  ? -1.18556  -1.43944  17.34418  1.000 18.32335 ? 95  GLU A N   1 
ATOM   790  C  CA  . GLU A 1 95  ? -0.02772  -0.56672  17.54765  1.000 20.47180 ? 95  GLU A CA  1 
ATOM   791  C  C   . GLU A 1 95  ? -0.12580  0.67039   16.66793  1.000 21.85193 ? 95  GLU A C   1 
ATOM   792  O  O   . GLU A 1 95  ? 0.18121   1.78400   17.10845  1.000 22.11064 ? 95  GLU A O   1 
ATOM   793  C  CB  . GLU A 1 95  ? 1.26652   -1.33720  17.28307  1.000 26.72166 ? 95  GLU A CB  1 
ATOM   794  C  CG  . GLU A 1 95  ? 2.44140   -0.92860  18.16854  1.000 49.60243 ? 95  GLU A CG  1 
ATOM   795  C  CD  . GLU A 1 95  ? 2.46501   -1.65320  19.51044  1.000 47.02151 ? 95  GLU A CD  1 
ATOM   796  O  OE1 . GLU A 1 95  ? 1.38203   -2.03929  20.00432  1.000 45.66773 ? 95  GLU A OE1 1 
ATOM   797  O  OE2 . GLU A 1 95  ? 3.57552   -1.83739  20.06698  1.000 51.98227 ? 95  GLU A OE2 1 
ATOM   798  N  N   . GLY A 1 96  ? -0.61201  0.51338   15.43312  1.000 16.75315 ? 96  GLY A N   1 
ATOM   799  C  CA  . GLY A 1 96  ? -0.79239  1.67702   14.57609  1.000 15.81313 ? 96  GLY A CA  1 
ATOM   800  C  C   . GLY A 1 96  ? -1.90867  2.58288   15.04757  1.000 21.66716 ? 96  GLY A C   1 
ATOM   801  O  O   . GLY A 1 96  ? -1.79181  3.81137   14.97974  1.000 19.77844 ? 96  GLY A O   1 
ATOM   802  N  N   . ILE A 1 97  ? -3.00756  1.98834   15.53205  1.000 16.19871 ? 97  ILE A N   1 
ATOM   803  C  CA  . ILE A 1 97  ? -4.15168  2.75704   16.01503  1.000 18.17980 ? 97  ILE A CA  1 
ATOM   804  C  C   . ILE A 1 97  ? -3.72895  3.65516   17.16270  1.000 20.03837 ? 97  ILE A C   1 
ATOM   805  O  O   . ILE A 1 97  ? -4.13360  4.81867   17.24372  1.000 19.87999 ? 97  ILE A O   1 
ATOM   806  C  CB  . ILE A 1 97  ? -5.28195  1.81800   16.46525  1.000 14.47646 ? 97  ILE A CB  1 
ATOM   807  C  CG1 . ILE A 1 97  ? -5.93872  1.17396   15.24949  1.000 18.24977 ? 97  ILE A CG1 1 
ATOM   808  C  CG2 . ILE A 1 97  ? -6.30706  2.59489   17.33697  1.000 17.59976 ? 97  ILE A CG2 1 
ATOM   809  C  CD1 . ILE A 1 97  ? -6.85047  -0.00731  15.60118  1.000 19.00868 ? 97  ILE A CD1 1 
ATOM   810  N  N   . ARG A 1 98  ? -2.93308  3.11454   18.07714  1.000 20.20382 ? 98  ARG A N   1 
ATOM   811  C  CA  . ARG A 1 98  ? -2.48192  3.89395   19.22662  1.000 24.14651 ? 98  ARG A CA  1 
ATOM   812  C  C   . ARG A 1 98  ? -1.72915  5.14455   18.78626  1.000 24.58869 ? 98  ARG A C   1 
ATOM   813  O  O   . ARG A 1 98  ? -1.85846  6.20720   19.40224  1.000 22.60635 ? 98  ARG A O   1 
ATOM   814  C  CB  . ARG A 1 98  ? -1.60271  3.01358   20.10185  1.000 30.11781 ? 98  ARG A CB  1 
ATOM   815  C  CG  . ARG A 1 98  ? -0.89230  3.67998   21.26406  1.000 44.81140 ? 98  ARG A CG  1 
ATOM   816  C  CD  . ARG A 1 98  ? -0.04551  2.63951   22.02280  1.000 46.43283 ? 98  ARG A CD  1 
ATOM   817  N  NE  . ARG A 1 98  ? -0.38101  1.25846   21.66969  1.000 46.19911 ? 98  ARG A NE  1 
ATOM   818  C  CZ  . ARG A 1 98  ? -1.44281  0.59294   22.11741  1.000 49.75033 ? 98  ARG A CZ  1 
ATOM   819  N  NH1 . ARG A 1 98  ? -2.31513  1.15408   22.94001  1.000 56.62087 ? 98  ARG A NH1 1 
ATOM   820  N  NH2 . ARG A 1 98  ? -1.64257  -0.66208  21.71627  1.000 45.86443 ? 98  ARG A NH2 1 
ATOM   821  N  N   . GLU A 1 99  ? -0.94239  5.03524   17.71506  1.000 20.29465 ? 99  GLU A N   1 
ATOM   822  C  CA  . GLU A 1 99  ? -0.14781  6.15407   17.23739  1.000 21.45449 ? 99  GLU A CA  1 
ATOM   823  C  C   . GLU A 1 99  ? -0.96965  7.12164   16.40200  1.000 24.05192 ? 99  GLU A C   1 
ATOM   824  O  O   . GLU A 1 99  ? -0.70220  8.33088   16.40168  1.000 27.45628 ? 99  GLU A O   1 
ATOM   825  C  CB  . GLU A 1 99  ? 1.05108   5.61036   16.45152  1.000 28.81930 ? 99  GLU A CB  1 
ATOM   826  C  CG  . GLU A 1 99  ? 2.08848   6.63991   16.07835  1.000 31.72701 ? 99  GLU A CG  1 
ATOM   827  C  CD  . GLU A 1 99  ? 2.78997   7.21804   17.28928  1.000 37.10650 ? 99  GLU A CD  1 
ATOM   828  O  OE1 . GLU A 1 99  ? 2.81064   6.54649   18.34514  1.000 43.36966 ? 99  GLU A OE1 1 
ATOM   829  O  OE2 . GLU A 1 99  ? 3.31610   8.35088   17.18885  1.000 36.83063 ? 99  GLU A OE2 1 
ATOM   830  N  N   . LEU A 1 100 ? -1.98489  6.62024   15.70534  1.000 15.95065 ? 100 LEU A N   1 
ATOM   831  C  CA  . LEU A 1 100 ? -2.87816  7.48263   14.95049  1.000 17.83926 ? 100 LEU A CA  1 
ATOM   832  C  C   . LEU A 1 100 ? -3.75015  8.32373   15.86573  1.000 23.54588 ? 100 LEU A C   1 
ATOM   833  O  O   . LEU A 1 100 ? -4.14873  9.43028   15.49689  1.000 26.22961 ? 100 LEU A O   1 
ATOM   834  C  CB  . LEU A 1 100 ? -3.77010  6.62903   14.05306  1.000 20.47725 ? 100 LEU A CB  1 
ATOM   835  C  CG  . LEU A 1 100 ? -3.20200  6.10230   12.74085  1.000 20.69001 ? 100 LEU A CG  1 
ATOM   836  C  CD1 . LEU A 1 100 ? -4.27138  5.22244   12.07137  1.000 19.68237 ? 100 LEU A CD1 1 
ATOM   837  C  CD2 . LEU A 1 100 ? -2.77531  7.25847   11.83611  1.000 23.77298 ? 100 LEU A CD2 1 
ATOM   838  N  N   . GLY A 1 101 ? -4.06124  7.81206   17.05447  1.000 27.46025 ? 101 GLY A N   1 
ATOM   839  C  CA  . GLY A 1 101 ? -5.05328  8.46953   17.87562  1.000 25.96526 ? 101 GLY A CA  1 
ATOM   840  C  C   . GLY A 1 101 ? -6.36613  8.53082   17.13026  1.000 27.01924 ? 101 GLY A C   1 
ATOM   841  O  O   . GLY A 1 101 ? -6.93120  9.61520   16.92616  1.000 27.64639 ? 101 GLY A O   1 
ATOM   842  N  N   . LEU A 1 102 ? -6.84002  7.37590   16.66245  1.000 21.19340 ? 102 LEU A N   1 
ATOM   843  C  CA  . LEU A 1 102 ? -8.05512  7.36053   15.86411  1.000 21.46322 ? 102 LEU A CA  1 
ATOM   844  C  C   . LEU A 1 102 ? -9.20919  7.90558   16.68211  1.000 16.34532 ? 102 LEU A C   1 
ATOM   845  O  O   . LEU A 1 102 ? -9.41391  7.49473   17.82864  1.000 21.81283 ? 102 LEU A O   1 
ATOM   846  C  CB  . LEU A 1 102 ? -8.40940  5.95272   15.42359  1.000 18.05986 ? 102 LEU A CB  1 
ATOM   847  C  CG  . LEU A 1 102 ? -7.86044  5.28375   14.19748  1.000 23.77621 ? 102 LEU A CG  1 
ATOM   848  C  CD1 . LEU A 1 102 ? -8.65840  3.98710   14.08305  1.000 19.18819 ? 102 LEU A CD1 1 
ATOM   849  C  CD2 . LEU A 1 102 ? -8.01850  6.16329   12.99738  1.000 21.28779 ? 102 LEU A CD2 1 
ATOM   850  N  N   . ASP A 1 103 ? -9.97559  8.77449   16.05954  1.000 18.26532 ? 103 ASP A N   1 
ATOM   851  C  CA  . ASP A 1 103 ? -11.14486 9.37922   16.68068  1.000 21.85710 ? 103 ASP A CA  1 
ATOM   852  C  C   . ASP A 1 103 ? -12.10174 8.30982   17.21246  1.000 20.89469 ? 103 ASP A C   1 
ATOM   853  O  O   . ASP A 1 103 ? -12.59948 7.46987   16.46797  1.000 17.22175 ? 103 ASP A O   1 
ATOM   854  C  CB  . ASP A 1 103 ? -11.80145 10.25460  15.62067  1.000 16.41161 ? 103 ASP A CB  1 
ATOM   855  C  CG  . ASP A 1 103 ? -13.00213 11.03975  16.11997  1.000 20.97639 ? 103 ASP A CG  1 
ATOM   856  O  OD1 . ASP A 1 103 ? -13.36469 10.93038  17.30117  1.000 19.78612 ? 103 ASP A OD1 1 
ATOM   857  O  OD2 . ASP A 1 103 ? -13.59959 11.75129  15.28505  1.000 24.08216 ? 103 ASP A OD2 1 
ATOM   858  N  N   . ARG A 1 104 ? -12.33203 8.31942   18.51449  1.000 17.96571 ? 104 ARG A N   1 
ATOM   859  C  CA  . ARG A 1 104 ? -13.18950 7.32001   19.13547  1.000 18.57099 ? 104 ARG A CA  1 
ATOM   860  C  C   . ARG A 1 104 ? -14.66454 7.69454   19.07637  1.000 16.80187 ? 104 ARG A C   1 
ATOM   861  O  O   . ARG A 1 104 ? -15.50136 6.92568   19.56662  1.000 17.63436 ? 104 ARG A O   1 
ATOM   862  C  CB  . ARG A 1 104 ? -12.75560 7.10888   20.59328  1.000 20.06456 ? 104 ARG A CB  1 
ATOM   863  C  CG  . ARG A 1 104 ? -11.31540 6.64027   20.75138  1.000 25.24551 ? 104 ARG A CG  1 
ATOM   864  C  CD  . ARG A 1 104 ? -10.91939 6.50349   22.21387  1.000 25.62798 ? 104 ARG A CD  1 
ATOM   865  N  NE  . ARG A 1 104 ? -11.79808 5.57637   22.91771  1.000 31.74659 ? 104 ARG A NE  1 
ATOM   866  C  CZ  . ARG A 1 104 ? -11.56174 4.28068   23.08101  1.000 33.92083 ? 104 ARG A CZ  1 
ATOM   867  N  NH1 . ARG A 1 104 ? -10.45118 3.71534   22.62991  1.000 34.36417 ? 104 ARG A NH1 1 
ATOM   868  N  NH2 . ARG A 1 104 ? -12.46814 3.53087   23.70432  1.000 38.18685 ? 104 ARG A NH2 1 
ATOM   869  N  N   A SER A 1 105 ? -15.01007 8.83161   18.48106  0.351 15.46414 ? 105 SER A N   1 
ATOM   870  N  N   B SER A 1 105 ? -15.00818 8.82248   18.46304  0.649 15.38137 ? 105 SER A N   1 
ATOM   871  C  CA  A SER A 1 105 ? -16.40030 9.26405   18.49084  0.351 15.14811 ? 105 SER A CA  1 
ATOM   872  C  CA  B SER A 1 105 ? -16.38737 9.30180   18.44830  0.649 15.09971 ? 105 SER A CA  1 
ATOM   873  C  C   A SER A 1 105 ? -17.28144 8.49460   17.51539  0.351 16.01456 ? 105 SER A C   1 
ATOM   874  C  C   B SER A 1 105 ? -17.25706 8.64616   17.38280  0.649 16.40993 ? 105 SER A C   1 
ATOM   875  O  O   A SER A 1 105 ? -18.50814 8.58767   17.62030  0.351 13.90995 ? 105 SER A O   1 
ATOM   876  O  O   B SER A 1 105 ? -18.44722 8.97645   17.28664  0.649 14.75782 ? 105 SER A O   1 
ATOM   877  C  CB  A SER A 1 105 ? -16.50017 10.76278  18.19264  0.351 18.78852 ? 105 SER A CB  1 
ATOM   878  C  CB  B SER A 1 105 ? -16.42240 10.81639  18.25327  0.649 18.86754 ? 105 SER A CB  1 
ATOM   879  O  OG  A SER A 1 105 ? -16.03075 11.07450  16.89461  0.351 18.66365 ? 105 SER A OG  1 
ATOM   880  O  OG  B SER A 1 105 ? -15.95421 11.47715  19.41265  0.649 20.92142 ? 105 SER A OG  1 
ATOM   881  N  N   . GLU A 1 106 ? -16.70814 7.73840   16.58561  1.000 14.11233 ? 106 GLU A N   1 
ATOM   882  C  CA  . GLU A 1 106 ? -17.51278 6.96802   15.65082  1.000 16.90531 ? 106 GLU A CA  1 
ATOM   883  C  C   . GLU A 1 106 ? -16.73970 5.72170   15.27518  1.000 16.01871 ? 106 GLU A C   1 
ATOM   884  O  O   . GLU A 1 106 ? -15.52622 5.64315   15.52515  1.000 13.51058 ? 106 GLU A O   1 
ATOM   885  C  CB  . GLU A 1 106 ? -17.88133 7.78933   14.40544  1.000 18.47339 ? 106 GLU A CB  1 
ATOM   886  C  CG  . GLU A 1 106 ? -16.69785 8.17819   13.53253  1.000 15.56775 ? 106 GLU A CG  1 
ATOM   887  C  CD  . GLU A 1 106 ? -17.12784 9.15898   12.43763  1.000 14.52100 ? 106 GLU A CD  1 
ATOM   888  O  OE1 . GLU A 1 106 ? -16.76211 10.38719  12.49646  1.000 19.19664 ? 106 GLU A OE1 1 
ATOM   889  O  OE2 . GLU A 1 106 ? -17.86239 8.71850   11.51974  1.000 18.27366 ? 106 GLU A OE2 1 
ATOM   890  N  N   . PRO A 1 107 ? -17.41974 4.70148   14.76983  1.000 13.15436 ? 107 PRO A N   1 
ATOM   891  C  CA  . PRO A 1 107 ? -16.73872 3.46530   14.37109  1.000 12.61448 ? 107 PRO A CA  1 
ATOM   892  C  C   . PRO A 1 107 ? -16.00142 3.63148   13.04695  1.000 11.62259 ? 107 PRO A C   1 
ATOM   893  O  O   . PRO A 1 107 ? -16.29832 4.52060   12.24680  1.000 9.62140  ? 107 PRO A O   1 
ATOM   894  C  CB  . PRO A 1 107 ? -17.90280 2.46466   14.22594  1.000 13.38833 ? 107 PRO A CB  1 
ATOM   895  C  CG  . PRO A 1 107 ? -19.06853 3.28248   13.89089  1.000 16.50073 ? 107 PRO A CG  1 
ATOM   896  C  CD  . PRO A 1 107 ? -18.89285 4.56785   14.67625  1.000 14.70351 ? 107 PRO A CD  1 
ATOM   897  N  N   . TRP A 1 108 ? -15.06045 2.71044   12.81222  1.000 11.34769 ? 108 TRP A N   1 
ATOM   898  C  CA  . TRP A 1 108 ? -14.21233 2.70587   11.61786  1.000 8.23054  ? 108 TRP A CA  1 
ATOM   899  C  C   . TRP A 1 108 ? -14.32088 1.37434   10.90145  1.000 10.43299 ? 108 TRP A C   1 
ATOM   900  O  O   . TRP A 1 108 ? -14.86912 0.40024   11.41329  1.000 10.88502 ? 108 TRP A O   1 
ATOM   901  C  CB  . TRP A 1 108 ? -12.74488 2.96682   11.99301  1.000 10.42762 ? 108 TRP A CB  1 
ATOM   902  C  CG  . TRP A 1 108 ? -12.51850 4.36136   12.49731  1.000 10.70269 ? 108 TRP A CG  1 
ATOM   903  C  CD1 . TRP A 1 108 ? -12.90603 4.86939   13.72245  1.000 11.57826 ? 108 TRP A CD1 1 
ATOM   904  C  CD2 . TRP A 1 108 ? -11.84366 5.43662   11.81788  1.000 11.07811 ? 108 TRP A CD2 1 
ATOM   905  N  NE1 . TRP A 1 108 ? -12.51888 6.19252   13.83300  1.000 11.97831 ? 108 TRP A NE1 1 
ATOM   906  C  CE2 . TRP A 1 108 ? -11.86453 6.55942   12.67834  1.000 12.92994 ? 108 TRP A CE2 1 
ATOM   907  C  CE3 . TRP A 1 108 ? -11.20740 5.55248   10.56414  1.000 11.98762 ? 108 TRP A CE3 1 
ATOM   908  C  CZ2 . TRP A 1 108 ? -11.30519 7.78226   12.31808  1.000 14.32937 ? 108 TRP A CZ2 1 
ATOM   909  C  CZ3 . TRP A 1 108 ? -10.63560 6.77079   10.21959  1.000 13.53678 ? 108 TRP A CZ3 1 
ATOM   910  C  CH2 . TRP A 1 108 ? -10.68964 7.85796   11.07046  1.000 12.28893 ? 108 TRP A CH2 1 
ATOM   911  N  N   . GLN A 1 109 ? -13.78494 1.35295   9.67829   1.000 8.81851  ? 109 GLN A N   1 
ATOM   912  C  CA  . GLN A 1 109 ? -13.78612 0.15931   8.84883   1.000 7.37733  ? 109 GLN A CA  1 
ATOM   913  C  C   . GLN A 1 109 ? -12.40350 0.08961   8.23355   1.000 8.10159  ? 109 GLN A C   1 
ATOM   914  O  O   . GLN A 1 109 ? -11.88511 1.12029   7.78176   1.000 9.41451  ? 109 GLN A O   1 
ATOM   915  C  CB  . GLN A 1 109 ? -14.85082 0.22498   7.74493   1.000 8.82268  ? 109 GLN A CB  1 
ATOM   916  C  CG  . GLN A 1 109 ? -14.90621 -0.99918  6.85280   1.000 10.42435 ? 109 GLN A CG  1 
ATOM   917  C  CD  . GLN A 1 109 ? -14.00967 -0.84817  5.64098   1.000 10.29437 ? 109 GLN A CD  1 
ATOM   918  O  OE1 . GLN A 1 109 ? -14.01192 0.20007   5.00417   1.000 10.58620 ? 109 GLN A OE1 1 
ATOM   919  N  NE2 . GLN A 1 109 ? -13.27797 -1.89852  5.29304   1.000 10.89522 ? 109 GLN A NE2 1 
ATOM   920  N  N   . ILE A 1 110 ? -11.77825 -1.07818  8.28255   1.000 8.05108  ? 110 ILE A N   1 
ATOM   921  C  CA  . ILE A 1 110 ? -10.43906 -1.23849  7.70439   1.000 7.50620  ? 110 ILE A CA  1 
ATOM   922  C  C   . ILE A 1 110 ? -10.43251 -2.29677  6.61392   1.000 9.79521  ? 110 ILE A C   1 
ATOM   923  O  O   . ILE A 1 110 ? -11.09431 -3.34312  6.70597   1.000 8.83050  ? 110 ILE A O   1 
ATOM   924  C  CB  . ILE A 1 110 ? -9.36709  -1.58033  8.74943   1.000 10.26614 ? 110 ILE A CB  1 
ATOM   925  C  CG1 . ILE A 1 110 ? -9.74735  -2.80517  9.59807   1.000 9.39387  ? 110 ILE A CG1 1 
ATOM   926  C  CG2 . ILE A 1 110 ? -9.13630  -0.36433  9.65607   1.000 11.79811 ? 110 ILE A CG2 1 
ATOM   927  C  CD1 . ILE A 1 110 ? -8.60176  -3.20938  10.56379  1.000 10.17075 ? 110 ILE A CD1 1 
ATOM   928  N  N   . ASN A 1 111 ? -9.62504  -2.02008  5.59419   1.000 7.85342  ? 111 ASN A N   1 
ATOM   929  C  CA  . ASN A 1 111 ? -9.21528  -2.99009  4.58422   1.000 5.72275  ? 111 ASN A CA  1 
ATOM   930  C  C   . ASN A 1 111 ? -7.83338  -3.47162  4.97643   1.000 5.90866  ? 111 ASN A C   1 
ATOM   931  O  O   . ASN A 1 111 ? -6.94181  -2.65354  5.23276   1.000 8.55183  ? 111 ASN A O   1 
ATOM   932  C  CB  . ASN A 1 111 ? -9.13755  -2.35416  3.19420   1.000 7.34774  ? 111 ASN A CB  1 
ATOM   933  C  CG  . ASN A 1 111 ? -10.48418 -2.10695  2.57885   1.000 9.70247  ? 111 ASN A CG  1 
ATOM   934  O  OD1 . ASN A 1 111 ? -11.50447 -2.46478  3.14929   1.000 8.20660  ? 111 ASN A OD1 1 
ATOM   935  N  ND2 . ASN A 1 111 ? -10.48943 -1.44457  1.41039   1.000 11.80348 ? 111 ASN A ND2 1 
ATOM   936  N  N   . VAL A 1 112 ? -7.62460  -4.77524  4.96389   1.000 5.98709  ? 112 VAL A N   1 
ATOM   937  C  CA  . VAL A 1 112 ? -6.33622  -5.35297  5.34320   1.000 7.77600  ? 112 VAL A CA  1 
ATOM   938  C  C   . VAL A 1 112 ? -5.85323  -6.18890  4.18363   1.000 8.83078  ? 112 VAL A C   1 
ATOM   939  O  O   . VAL A 1 112 ? -6.54318  -7.14421  3.77069   1.000 7.74984  ? 112 VAL A O   1 
ATOM   940  C  CB  . VAL A 1 112 ? -6.43594  -6.21179  6.61439   1.000 7.75080  ? 112 VAL A CB  1 
ATOM   941  C  CG1 . VAL A 1 112 ? -5.06750  -6.73536  7.02373   1.000 6.99179  ? 112 VAL A CG1 1 
ATOM   942  C  CG2 . VAL A 1 112 ? -7.04192  -5.36570  7.75639   1.000 10.38965 ? 112 VAL A CG2 1 
ATOM   943  N  N   . HIS A 1 113 ? -4.67668  -5.81805  3.66054   1.000 5.56797  ? 113 HIS A N   1 
ATOM   944  C  CA  . HIS A 1 113 ? -4.04075  -6.50157  2.53128   1.000 6.04613  ? 113 HIS A CA  1 
ATOM   945  C  C   . HIS A 1 113 ? -2.76509  -7.15743  3.00134   1.000 5.85000  ? 113 HIS A C   1 
ATOM   946  O  O   . HIS A 1 113 ? -1.81210  -6.46200  3.38601   1.000 6.56519  ? 113 HIS A O   1 
ATOM   947  C  CB  . HIS A 1 113 ? -3.70823  -5.50764  1.41043   1.000 7.11009  ? 113 HIS A CB  1 
ATOM   948  C  CG  . HIS A 1 113 ? -4.88235  -4.73777  0.88615   1.000 9.60797  ? 113 HIS A CG  1 
ATOM   949  N  ND1 . HIS A 1 113 ? -5.44691  -5.00313  -0.34015  1.000 15.26359 ? 113 HIS A ND1 1 
ATOM   950  C  CD2 . HIS A 1 113 ? -5.58539  -3.70658  1.41070   1.000 10.97146 ? 113 HIS A CD2 1 
ATOM   951  C  CE1 . HIS A 1 113 ? -6.46176  -4.18066  -0.54592  1.000 14.46488 ? 113 HIS A CE1 1 
ATOM   952  N  NE2 . HIS A 1 113 ? -6.56792  -3.38442  0.49558   1.000 11.93095 ? 113 HIS A NE2 1 
ATOM   953  N  N   . GLN A 1 114 ? -2.71720  -8.48482  2.93502   1.000 5.39856  ? 114 GLN A N   1 
ATOM   954  C  CA  . GLN A 1 114 ? -1.50518  -9.22489  3.25007   1.000 7.04821  ? 114 GLN A CA  1 
ATOM   955  C  C   . GLN A 1 114 ? -0.81012  -9.48549  1.92013   1.000 6.03036  ? 114 GLN A C   1 
ATOM   956  O  O   . GLN A 1 114 ? -1.30422  -10.26009 1.10146   1.000 8.72774  ? 114 GLN A O   1 
ATOM   957  C  CB  . GLN A 1 114 ? -1.84117  -10.51197 3.99440   1.000 8.64819  ? 114 GLN A CB  1 
ATOM   958  C  CG  . GLN A 1 114 ? -0.61811  -11.30491 4.31213   1.000 7.85216  ? 114 GLN A CG  1 
ATOM   959  C  CD  . GLN A 1 114 ? -0.91464  -12.61707 5.01512   1.000 9.58319  ? 114 GLN A CD  1 
ATOM   960  O  OE1 . GLN A 1 114 ? -2.06560  -13.02545 5.14493   1.000 13.01367 ? 114 GLN A OE1 1 
ATOM   961  N  NE2 . GLN A 1 114 ? 0.13884   -13.27014 5.49108   1.000 11.82431 ? 114 GLN A NE2 1 
ATOM   962  N  N   . ASN A 1 115 ? 0.33783   -8.84099  1.70594   1.000 5.40459  ? 115 ASN A N   1 
ATOM   963  C  CA  . ASN A 1 115 ? 1.03670   -8.87717  0.40986   1.000 6.49154  ? 115 ASN A CA  1 
ATOM   964  C  C   . ASN A 1 115 ? 2.44445   -9.43877  0.52367   1.000 6.75029  ? 115 ASN A C   1 
ATOM   965  O  O   . ASN A 1 115 ? 3.21008   -9.06434  1.43454   1.000 8.89232  ? 115 ASN A O   1 
ATOM   966  C  CB  . ASN A 1 115 ? 1.20299   -7.47617  -0.20623  1.000 8.00814  ? 115 ASN A CB  1 
ATOM   967  C  CG  . ASN A 1 115 ? -0.07525  -6.88594  -0.80004  1.000 8.76809  ? 115 ASN A CG  1 
ATOM   968  O  OD1 . ASN A 1 115 ? -1.20182  -7.27702  -0.47865  1.000 12.23642 ? 115 ASN A OD1 1 
ATOM   969  N  ND2 . ASN A 1 115 ? 0.11931   -5.85158  -1.63440  1.000 14.84020 ? 115 ASN A ND2 1 
ATOM   970  N  N   . ARG A 1 116 ? 2.81658   -10.27677 -0.45490  1.000 8.51164  ? 116 ARG A N   1 
ATOM   971  C  CA  . ARG A 1 116 ? 4.20668   -10.61972 -0.73018  1.000 7.30355  ? 116 ARG A CA  1 
ATOM   972  C  C   . ARG A 1 116 ? 4.51678   -10.16364 -2.14110  1.000 8.44843  ? 116 ARG A C   1 
ATOM   973  O  O   . ARG A 1 116 ? 3.74771   -10.47350 -3.06514  1.000 9.77531  ? 116 ARG A O   1 
ATOM   974  C  CB  . ARG A 1 116 ? 4.45737   -12.12020 -0.61713  1.000 11.08992 ? 116 ARG A CB  1 
ATOM   975  C  CG  . ARG A 1 116 ? 5.79539   -12.54684 -1.26129  1.000 11.61112 ? 116 ARG A CG  1 
ATOM   976  C  CD  . ARG A 1 116 ? 6.04537   -13.99502 -0.95930  1.000 12.18560 ? 116 ARG A CD  1 
ATOM   977  N  NE  . ARG A 1 116 ? 6.43499   -14.18908 0.43066   1.000 12.40725 ? 116 ARG A NE  1 
ATOM   978  C  CZ  . ARG A 1 116 ? 6.69904   -15.37870 0.95037   1.000 17.32068 ? 116 ARG A CZ  1 
ATOM   979  N  NH1 . ARG A 1 116 ? 6.57019   -16.48329 0.22587   1.000 16.73807 ? 116 ARG A NH1 1 
ATOM   980  N  NH2 . ARG A 1 116 ? 7.10234   -15.45627 2.21732   1.000 14.62011 ? 116 ARG A NH2 1 
ATOM   981  N  N   . THR A 1 117 ? 5.62135   -9.42708  -2.30278  1.000 6.20270  ? 117 THR A N   1 
ATOM   982  C  CA  . THR A 1 117 ? 6.17193   -9.12026  -3.61711  1.000 5.66695  ? 117 THR A CA  1 
ATOM   983  C  C   . THR A 1 117 ? 7.51707   -9.81501  -3.74763  1.000 9.73745  ? 117 THR A C   1 
ATOM   984  O  O   . THR A 1 117 ? 8.37354   -9.69341  -2.86470  1.000 10.41054 ? 117 THR A O   1 
ATOM   985  C  CB  . THR A 1 117 ? 6.30594   -7.61664  -3.83827  1.000 7.73188  ? 117 THR A CB  1 
ATOM   986  O  OG1 . THR A 1 117 ? 4.97894   -7.10115  -4.06053  1.000 11.11253 ? 117 THR A OG1 1 
ATOM   987  C  CG2 . THR A 1 117 ? 7.12887   -7.29612  -5.10188  1.000 8.29434  ? 117 THR A CG2 1 
ATOM   988  N  N   . ARG A 1 118 ? 7.67973   -10.54690 -4.84211  1.000 7.94958  ? 118 ARG A N   1 
ATOM   989  C  CA  . ARG A 1 118 ? 8.91420   -11.24777 -5.16416  1.000 10.52299 ? 118 ARG A CA  1 
ATOM   990  C  C   . ARG A 1 118 ? 9.75709   -10.43897 -6.13779  1.000 10.70995 ? 118 ARG A C   1 
ATOM   991  O  O   . ARG A 1 118 ? 9.22515   -9.78927  -7.05605  1.000 11.14572 ? 118 ARG A O   1 
ATOM   992  C  CB  . ARG A 1 118 ? 8.58590   -12.60806 -5.77798  1.000 14.58588 ? 118 ARG A CB  1 
ATOM   993  C  CG  . ARG A 1 118 ? 7.94700   -13.57809 -4.79824  1.000 16.39445 ? 118 ARG A CG  1 
ATOM   994  C  CD  . ARG A 1 118 ? 7.99997   -15.05348 -5.22376  1.000 24.07898 ? 118 ARG A CD  1 
ATOM   995  N  NE  . ARG A 1 118 ? 7.97394   -15.89391 -4.03197  1.000 37.32331 ? 118 ARG A NE  1 
ATOM   996  C  CZ  . ARG A 1 118 ? 9.00439   -16.06562 -3.20871  1.000 29.90333 ? 118 ARG A CZ  1 
ATOM   997  N  NH1 . ARG A 1 118 ? 10.19976  -15.54892 -3.46999  1.000 37.31561 ? 118 ARG A NH1 1 
ATOM   998  N  NH2 . ARG A 1 118 ? 8.83578   -16.78207 -2.10311  1.000 40.72119 ? 118 ARG A NH2 1 
ATOM   999  N  N   . ALA A 1 119 ? 11.08142  -10.50317 -5.95896  1.000 10.22877 ? 119 ALA A N   1 
ATOM   1000 C  CA  . ALA A 1 119 ? 12.04630  -9.98200  -6.91519  1.000 11.90886 ? 119 ALA A CA  1 
ATOM   1001 C  C   . ALA A 1 119 ? 12.98797  -11.10516 -7.32850  1.000 11.89495 ? 119 ALA A C   1 
ATOM   1002 O  O   . ALA A 1 119 ? 13.18041  -12.07016 -6.59494  1.000 14.08163 ? 119 ALA A O   1 
ATOM   1003 C  CB  . ALA A 1 119 ? 12.86466  -8.81072  -6.35140  1.000 13.71491 ? 119 ALA A CB  1 
ATOM   1004 N  N   . ASP A 1 120 ? 13.53372  -10.98847 -8.53886  1.000 14.04815 ? 120 ASP A N   1 
ATOM   1005 C  CA  . ASP A 1 120 ? 14.56434  -11.91519 -8.99593  1.000 14.60484 ? 120 ASP A CA  1 
ATOM   1006 C  C   . ASP A 1 120 ? 15.53071  -11.14675 -9.88492  1.000 15.48333 ? 120 ASP A C   1 
ATOM   1007 O  O   . ASP A 1 120 ? 15.25192  -10.03789 -10.33430 1.000 14.62923 ? 120 ASP A O   1 
ATOM   1008 C  CB  . ASP A 1 120 ? 13.94525  -13.11469 -9.71983  1.000 17.82170 ? 120 ASP A CB  1 
ATOM   1009 C  CG  . ASP A 1 120 ? 14.85339  -14.36591 -9.70520  1.000 25.18726 ? 120 ASP A CG  1 
ATOM   1010 O  OD1 . ASP A 1 120 ? 16.06975  -14.27212 -9.39878  1.000 23.12694 ? 120 ASP A OD1 1 
ATOM   1011 O  OD2 . ASP A 1 120 ? 14.32828  -15.45867 -10.00844 1.000 35.38933 ? 120 ASP A OD2 1 
ATOM   1012 N  N   . GLY A 1 121 ? 16.69530  -11.74715 -10.15340 1.000 17.82361 ? 121 GLY A N   1 
ATOM   1013 C  CA  . GLY A 1 121 ? 17.59065  -11.09256 -11.08116 1.000 19.68168 ? 121 GLY A CA  1 
ATOM   1014 C  C   . GLY A 1 121 ? 16.90678  -10.75238 -12.39667 1.000 18.38962 ? 121 GLY A C   1 
ATOM   1015 O  O   . GLY A 1 121 ? 16.24265  -11.59894 -13.00695 1.000 23.26869 ? 121 GLY A O   1 
ATOM   1016 N  N   . GLY A 1 122 ? 17.02084  -9.49247  -12.79294 1.000 21.43090 ? 122 GLY A N   1 
ATOM   1017 C  CA  . GLY A 1 122 ? 16.42276  -9.00150  -14.01482 1.000 19.76022 ? 122 GLY A CA  1 
ATOM   1018 C  C   . GLY A 1 122 ? 14.94475  -8.71441  -13.92868 1.000 22.76808 ? 122 GLY A C   1 
ATOM   1019 O  O   . GLY A 1 122 ? 14.38294  -8.17159  -14.89332 1.000 19.86602 ? 122 GLY A O   1 
ATOM   1020 N  N   . ARG A 1 123 ? 14.27952  -9.06701  -12.82707 1.000 15.06148 ? 123 ARG A N   1 
ATOM   1021 C  CA  . ARG A 1 123 ? 12.84153  -8.81303  -12.69082 1.000 15.25870 ? 123 ARG A CA  1 
ATOM   1022 C  C   . ARG A 1 123 ? 12.54438  -8.19965  -11.33109 1.000 11.23149 ? 123 ARG A C   1 
ATOM   1023 O  O   . ARG A 1 123 ? 12.26365  -8.92415  -10.35999 1.000 12.27442 ? 123 ARG A O   1 
ATOM   1024 C  CB  . ARG A 1 123 ? 12.00517  -10.06746 -12.87574 1.000 12.78252 ? 123 ARG A CB  1 
ATOM   1025 C  CG  . ARG A 1 123 ? 10.46733  -9.79068  -12.92205 1.000 15.30636 ? 123 ARG A CG  1 
ATOM   1026 C  CD  . ARG A 1 123 ? 10.01737  -9.32165  -14.27385 1.000 15.73498 ? 123 ARG A CD  1 
ATOM   1027 N  NE  . ARG A 1 123 ? 8.61224   -8.91304  -14.25036 1.000 11.80051 ? 123 ARG A NE  1 
ATOM   1028 C  CZ  . ARG A 1 123 ? 7.58377   -9.73021  -14.42529 1.000 13.13133 ? 123 ARG A CZ  1 
ATOM   1029 N  NH1 . ARG A 1 123 ? 7.74764   -11.01150 -14.71869 1.000 16.14243 ? 123 ARG A NH1 1 
ATOM   1030 N  NH2 . ARG A 1 123 ? 6.35099   -9.24292  -14.29074 1.000 12.97189 ? 123 ARG A NH2 1 
ATOM   1031 N  N   . PRO A 1 124 ? 12.52986  -6.88005  -11.25372 1.000 12.42794 ? 124 PRO A N   1 
ATOM   1032 C  CA  . PRO A 1 124 ? 12.11906  -6.22212  -10.01169 1.000 11.57971 ? 124 PRO A CA  1 
ATOM   1033 C  C   . PRO A 1 124 ? 10.66444  -6.52728  -9.69380  1.000 11.63473 ? 124 PRO A C   1 
ATOM   1034 O  O   . PRO A 1 124 ? 9.87884   -6.99096  -10.53302 1.000 13.19449 ? 124 PRO A O   1 
ATOM   1035 C  CB  . PRO A 1 124 ? 12.33122  -4.73363  -10.29651 1.000 10.87581 ? 124 PRO A CB  1 
ATOM   1036 C  CG  . PRO A 1 124 ? 13.17341  -4.67503  -11.56159 1.000 21.62129 ? 124 PRO A CG  1 
ATOM   1037 C  CD  . PRO A 1 124 ? 12.81684  -5.91138  -12.32158 1.000 15.23224 ? 124 PRO A CD  1 
ATOM   1038 N  N   . GLY A 1 125 ? 10.32405  -6.32487  -8.42633  1.000 9.82907  ? 125 GLY A N   1 
ATOM   1039 C  CA  . GLY A 1 125 ? 8.95900   -6.50165  -7.99485  1.000 10.03747 ? 125 GLY A CA  1 
ATOM   1040 C  C   . GLY A 1 125 ? 8.30784   -5.15364  -7.78611  1.000 9.27929  ? 125 GLY A C   1 
ATOM   1041 O  O   . GLY A 1 125 ? 8.64928   -4.39692  -6.87560  1.000 11.11531 ? 125 GLY A O   1 
ATOM   1042 N  N   . PRO A 1 126 ? 7.36171   -4.80124  -8.64150  1.000 8.78612  ? 126 PRO A N   1 
ATOM   1043 C  CA  . PRO A 1 126 ? 6.78158   -3.46362  -8.51808  1.000 9.46461  ? 126 PRO A CA  1 
ATOM   1044 C  C   . PRO A 1 126 ? 5.88149   -3.37870  -7.30504  1.000 10.24778 ? 126 PRO A C   1 
ATOM   1045 O  O   . PRO A 1 126 ? 5.11985   -4.30329  -6.99467  1.000 12.13831 ? 126 PRO A O   1 
ATOM   1046 C  CB  . PRO A 1 126 ? 5.97510   -3.28812  -9.81453  1.000 14.01615 ? 126 PRO A CB  1 
ATOM   1047 C  CG  . PRO A 1 126 ? 6.50475   -4.34500  -10.73909 1.000 19.78012 ? 126 PRO A CG  1 
ATOM   1048 C  CD  . PRO A 1 126 ? 6.89043   -5.49608  -9.84959  1.000 13.45029 ? 126 PRO A CD  1 
ATOM   1049 N  N   . LEU A 1 127 ? 5.94258   -2.23929  -6.63135  1.000 8.72969  ? 127 LEU A N   1 
ATOM   1050 C  CA  . LEU A 1 127 ? 5.14260   -2.05713  -5.43110  1.000 8.22445  ? 127 LEU A CA  1 
ATOM   1051 C  C   . LEU A 1 127 ? 4.02045   -1.04956  -5.61283  1.000 12.10290 ? 127 LEU A C   1 
ATOM   1052 O  O   . LEU A 1 127 ? 2.94718   -1.22670  -5.03614  1.000 13.95704 ? 127 LEU A O   1 
ATOM   1053 C  CB  . LEU A 1 127 ? 6.04372   -1.61183  -4.28564  1.000 9.22677  ? 127 LEU A CB  1 
ATOM   1054 C  CG  . LEU A 1 127 ? 7.09842   -2.63469  -3.84979  1.000 8.12519  ? 127 LEU A CG  1 
ATOM   1055 C  CD1 . LEU A 1 127 ? 7.99132   -2.04918  -2.74375  1.000 12.62753 ? 127 LEU A CD1 1 
ATOM   1056 C  CD2 . LEU A 1 127 ? 6.35949   -3.87492  -3.34095  1.000 10.54331 ? 127 LEU A CD2 1 
ATOM   1057 N  N   . THR A 1 128 ? 4.24862   0.00659   -6.38999  1.000 11.05912 ? 128 THR A N   1 
ATOM   1058 C  CA  . THR A 1 128 ? 3.22307   1.01736   -6.67060  1.000 10.91914 ? 128 THR A CA  1 
ATOM   1059 C  C   . THR A 1 128 ? 3.16335   1.27431   -8.17542  1.000 11.50647 ? 128 THR A C   1 
ATOM   1060 O  O   . THR A 1 128 ? 3.56887   2.32897   -8.66780  1.000 12.95857 ? 128 THR A O   1 
ATOM   1061 C  CB  . THR A 1 128 ? 3.45682   2.30995   -5.87784  1.000 11.10614 ? 128 THR A CB  1 
ATOM   1062 O  OG1 . THR A 1 128 ? 4.72490   2.87842   -6.20916  1.000 10.37738 ? 128 THR A OG1 1 
ATOM   1063 C  CG2 . THR A 1 128 ? 3.43895   2.04062   -4.34944  1.000 11.61271 ? 128 THR A CG2 1 
ATOM   1064 N  N   . PRO A 1 129 ? 2.61516   0.32498   -8.93638  1.000 13.76401 ? 129 PRO A N   1 
ATOM   1065 C  CA  . PRO A 1 129 ? 2.37319   0.58975   -10.35637 1.000 16.67786 ? 129 PRO A CA  1 
ATOM   1066 C  C   . PRO A 1 129 ? 1.37483   1.70821   -10.58927 1.000 18.36739 ? 129 PRO A C   1 
ATOM   1067 O  O   . PRO A 1 129 ? 1.34601   2.26200   -11.69866 1.000 22.12053 ? 129 PRO A O   1 
ATOM   1068 C  CB  . PRO A 1 129 ? 1.86467   -0.75697  -10.88052 1.000 18.04081 ? 129 PRO A CB  1 
ATOM   1069 C  CG  . PRO A 1 129 ? 1.33416   -1.46440  -9.67173  1.000 16.40465 ? 129 PRO A CG  1 
ATOM   1070 C  CD  . PRO A 1 129 ? 2.20524   -1.02991  -8.52590  1.000 15.23961 ? 129 PRO A CD  1 
ATOM   1071 N  N   . GLU A 1 130 ? 0.57089   2.06263   -9.57798  1.000 13.92791 ? 130 GLU A N   1 
ATOM   1072 C  CA  . GLU A 1 130 ? -0.27345  3.25416   -9.58925  1.000 17.77260 ? 130 GLU A CA  1 
ATOM   1073 C  C   . GLU A 1 130 ? 0.53725   4.53374   -9.77733  1.000 18.34584 ? 130 GLU A C   1 
ATOM   1074 O  O   . GLU A 1 130 ? -0.03393  5.55720   -10.16672 1.000 22.06789 ? 130 GLU A O   1 
ATOM   1075 C  CB  . GLU A 1 130 ? -1.05810  3.37408   -8.25550  1.000 17.54699 ? 130 GLU A CB  1 
ATOM   1076 C  CG  . GLU A 1 130 ? -1.89013  2.14304   -7.80887  1.000 21.48771 ? 130 GLU A CG  1 
ATOM   1077 C  CD  . GLU A 1 130 ? -1.12521  1.14862   -6.91791  1.000 21.57726 ? 130 GLU A CD  1 
ATOM   1078 O  OE1 . GLU A 1 130 ? 0.09955   1.07290   -7.02213  1.000 17.97950 ? 130 GLU A OE1 1 
ATOM   1079 O  OE2 . GLU A 1 130 ? -1.73778  0.43206   -6.08327  1.000 24.19726 ? 130 GLU A OE2 1 
ATOM   1080 N  N   . GLY A 1 131 ? 1.84429   4.50189   -9.50965  1.000 13.93028 ? 131 GLY A N   1 
ATOM   1081 C  CA  . GLY A 1 131 ? 2.65019   5.71333   -9.42353  1.000 13.97535 ? 131 GLY A CA  1 
ATOM   1082 C  C   . GLY A 1 131 ? 2.39068   6.42223   -8.10114  1.000 10.77994 ? 131 GLY A C   1 
ATOM   1083 O  O   . GLY A 1 131 ? 1.92738   5.81954   -7.14800  1.000 10.61461 ? 131 GLY A O   1 
ATOM   1084 N  N   . VAL A 1 132 ? 2.72653   7.71064   -8.05182  1.000 8.92184  ? 132 VAL A N   1 
ATOM   1085 C  CA  . VAL A 1 132 ? 2.44480   8.53761   -6.88311  1.000 7.25634  ? 132 VAL A CA  1 
ATOM   1086 C  C   . VAL A 1 132 ? 0.93921   8.64807   -6.73024  1.000 9.09882  ? 132 VAL A C   1 
ATOM   1087 O  O   . VAL A 1 132 ? 0.24346   9.05881   -7.66810  1.000 11.81776 ? 132 VAL A O   1 
ATOM   1088 C  CB  . VAL A 1 132 ? 3.08317   9.92798   -7.03558  1.000 9.36406  ? 132 VAL A CB  1 
ATOM   1089 C  CG1 . VAL A 1 132 ? 2.69423   10.81259  -5.86907  1.000 9.07500  ? 132 VAL A CG1 1 
ATOM   1090 C  CG2 . VAL A 1 132 ? 4.63744   9.82991   -7.13465  1.000 9.78085  ? 132 VAL A CG2 1 
ATOM   1091 N  N   . HIS A 1 133 ? 0.41813   8.27164   -5.56184  1.000 7.98126  ? 133 HIS A N   1 
ATOM   1092 C  CA  . HIS A 1 133 ? -1.03714  8.16645   -5.45389  1.000 8.61196  ? 133 HIS A CA  1 
ATOM   1093 C  C   . HIS A 1 133 ? -1.48699  8.44645   -4.02984  1.000 7.16516  ? 133 HIS A C   1 
ATOM   1094 O  O   . HIS A 1 133 ? -0.70848  8.36969   -3.06237  1.000 7.61911  ? 133 HIS A O   1 
ATOM   1095 C  CB  . HIS A 1 133 ? -1.55350  6.77642   -5.85749  1.000 8.22455  ? 133 HIS A CB  1 
ATOM   1096 C  CG  . HIS A 1 133 ? -1.04754  5.68601   -4.96956  1.000 9.87123  ? 133 HIS A CG  1 
ATOM   1097 N  ND1 . HIS A 1 133 ? 0.23805   5.18432   -5.07667  1.000 8.90981  ? 133 HIS A ND1 1 
ATOM   1098 C  CD2 . HIS A 1 133 ? -1.63177  5.02965   -3.93991  1.000 11.05094 ? 133 HIS A CD2 1 
ATOM   1099 C  CE1 . HIS A 1 133 ? 0.40843   4.24319   -4.16668  1.000 9.89080  ? 133 HIS A CE1 1 
ATOM   1100 N  NE2 . HIS A 1 133 ? -0.70199  4.14128   -3.45666  1.000 11.49568 ? 133 HIS A NE2 1 
ATOM   1101 N  N   . HIS A 1 134 ? -2.79157  8.74232   -3.91681  1.000 9.58414  ? 134 HIS A N   1 
ATOM   1102 C  CA  . HIS A 1 134 ? -3.54653  8.56019   -2.67967  1.000 9.11287  ? 134 HIS A CA  1 
ATOM   1103 C  C   . HIS A 1 134 ? -4.31700  7.24574   -2.75275  1.000 8.22355  ? 134 HIS A C   1 
ATOM   1104 O  O   . HIS A 1 134 ? -4.81464  6.89092   -3.81342  1.000 10.09558 ? 134 HIS A O   1 
ATOM   1105 C  CB  . HIS A 1 134 ? -4.54444  9.70986   -2.47777  1.000 10.63373 ? 134 HIS A CB  1 
ATOM   1106 C  CG  . HIS A 1 134 ? -3.91886  11.05453  -2.52770  1.000 12.72572 ? 134 HIS A CG  1 
ATOM   1107 N  ND1 . HIS A 1 134 ? -3.46674  11.69808  -1.40147  1.000 13.23236 ? 134 HIS A ND1 1 
ATOM   1108 C  CD2 . HIS A 1 134 ? -3.63344  11.87129  -3.57276  1.000 14.74062 ? 134 HIS A CD2 1 
ATOM   1109 C  CE1 . HIS A 1 134 ? -2.95293  12.87460  -1.74126  1.000 14.01072 ? 134 HIS A CE1 1 
ATOM   1110 N  NE2 . HIS A 1 134 ? -3.03093  12.99575  -3.05426  1.000 13.84378 ? 134 HIS A NE2 1 
ATOM   1111 N  N   . ASP A 1 135 ? -4.40436  6.51786   -1.63161  1.000 8.93704  ? 135 ASP A N   1 
ATOM   1112 C  CA  . ASP A 1 135 ? -5.23515  5.30025   -1.61327  1.000 8.58641  ? 135 ASP A CA  1 
ATOM   1113 C  C   . ASP A 1 135 ? -6.72776  5.60769   -1.64724  1.000 9.96752  ? 135 ASP A C   1 
ATOM   1114 O  O   . ASP A 1 135 ? -7.51458  4.73735   -2.05170  1.000 10.77004 ? 135 ASP A O   1 
ATOM   1115 C  CB  . ASP A 1 135 ? -4.98193  4.45089   -0.35695  1.000 11.79031 ? 135 ASP A CB  1 
ATOM   1116 C  CG  . ASP A 1 135 ? -3.67000  3.69298   -0.38087  1.000 16.75039 ? 135 ASP A CG  1 
ATOM   1117 O  OD1 . ASP A 1 135 ? -2.81789  3.98740   -1.24305  1.000 10.49983 ? 135 ASP A OD1 1 
ATOM   1118 O  OD2 . ASP A 1 135 ? -3.49552  2.78382   0.48293   1.000 16.79142 ? 135 ASP A OD2 1 
ATOM   1119 N  N   . GLY A 1 136 ? -7.12924  6.80378   -1.23739  1.000 9.85240  ? 136 GLY A N   1 
ATOM   1120 C  CA  . GLY A 1 136 ? -8.52422  7.17057   -1.18886  1.000 10.38174 ? 136 GLY A CA  1 
ATOM   1121 C  C   . GLY A 1 136 ? -9.13088  7.12879   0.19522   1.000 9.98338  ? 136 GLY A C   1 
ATOM   1122 O  O   . GLY A 1 136 ? -10.32691 7.44224   0.34352   1.000 13.27696 ? 136 GLY A O   1 
ATOM   1123 N  N   . HIS A 1 137 ? -8.37778  6.71389   1.19029   1.000 9.79708  ? 137 HIS A N   1 
ATOM   1124 C  CA  . HIS A 1 137 ? -8.86631  6.56879   2.55264   1.000 7.86004  ? 137 HIS A CA  1 
ATOM   1125 C  C   . HIS A 1 137 ? -8.40417  7.75891   3.38709   1.000 13.00254 ? 137 HIS A C   1 
ATOM   1126 O  O   . HIS A 1 137 ? -7.78522  8.70921   2.89391   1.000 18.77751 ? 137 HIS A O   1 
ATOM   1127 C  CB  . HIS A 1 137 ? -8.38940  5.24639   3.14634   1.000 8.14056  ? 137 HIS A CB  1 
ATOM   1128 C  CG  . HIS A 1 137 ? -8.84571  4.03238   2.39968   1.000 9.50403  ? 137 HIS A CG  1 
ATOM   1129 N  ND1 . HIS A 1 137 ? -9.89362  3.24486   2.82989   1.000 9.94314  ? 137 HIS A ND1 1 
ATOM   1130 C  CD2 . HIS A 1 137 ? -8.38365  3.45480   1.26644   1.000 10.00573 ? 137 HIS A CD2 1 
ATOM   1131 C  CE1 . HIS A 1 137 ? -10.06525 2.24547   1.98878   1.000 10.92278 ? 137 HIS A CE1 1 
ATOM   1132 N  NE2 . HIS A 1 137 ? -9.15598  2.34543   1.02645   1.000 8.50772  ? 137 HIS A NE2 1 
ATOM   1133 N  N   . GLU A 1 138 ? -8.70163  7.71324   4.67832   1.000 7.61755  ? 138 GLU A N   1 
ATOM   1134 C  CA  . GLU A 1 138 ? -8.29266  8.77863   5.57465   1.000 8.10374  ? 138 GLU A CA  1 
ATOM   1135 C  C   . GLU A 1 138 ? -6.88540  8.54715   6.11144   1.000 8.37020  ? 138 GLU A C   1 
ATOM   1136 O  O   . GLU A 1 138 ? -6.06049  9.47844   6.14555   1.000 11.22992 ? 138 GLU A O   1 
ATOM   1137 C  CB  . GLU A 1 138 ? -9.31414  8.89960   6.72224   1.000 11.88922 ? 138 GLU A CB  1 
ATOM   1138 C  CG  . GLU A 1 138 ? -9.10153  10.16331  7.56302   1.000 10.17377 ? 138 GLU A CG  1 
ATOM   1139 C  CD  . GLU A 1 138 ? -10.27601 10.54627  8.43275   1.000 12.55287 ? 138 GLU A CD  1 
ATOM   1140 O  OE1 . GLU A 1 138 ? -11.34601 9.94327   8.29117   1.000 12.69979 ? 138 GLU A OE1 1 
ATOM   1141 O  OE2 . GLU A 1 138 ? -10.09176 11.46938  9.25665   1.000 17.21593 ? 138 GLU A OE2 1 
ATOM   1142 N  N   . PHE A 1 139 ? -6.59931  7.32637   6.55736   1.000 8.51376  ? 139 PHE A N   1 
ATOM   1143 C  CA  . PHE A 1 139 ? -5.27422  6.96973   7.04234   1.000 9.78850  ? 139 PHE A CA  1 
ATOM   1144 C  C   . PHE A 1 139 ? -4.87932  5.64265   6.43314   1.000 9.23003  ? 139 PHE A C   1 
ATOM   1145 O  O   . PHE A 1 139 ? -5.74653  4.82208   6.11481   1.000 8.68923  ? 139 PHE A O   1 
ATOM   1146 C  CB  . PHE A 1 139 ? -5.25951  6.81689   8.56167   1.000 9.78224  ? 139 PHE A CB  1 
ATOM   1147 C  CG  . PHE A 1 139 ? -5.60855  8.06399   9.29451   1.000 10.72127 ? 139 PHE A CG  1 
ATOM   1148 C  CD1 . PHE A 1 139 ? -4.75247  9.13807   9.27560   1.000 13.56147 ? 139 PHE A CD1 1 
ATOM   1149 C  CD2 . PHE A 1 139 ? -6.80076  8.14319   10.01781  1.000 11.78412 ? 139 PHE A CD2 1 
ATOM   1150 C  CE1 . PHE A 1 139 ? -5.06896  10.29283  9.94774   1.000 15.85608 ? 139 PHE A CE1 1 
ATOM   1151 C  CE2 . PHE A 1 139 ? -7.14102  9.32204   10.70730  1.000 15.77282 ? 139 PHE A CE2 1 
ATOM   1152 C  CZ  . PHE A 1 139 ? -6.26008  10.39496  10.66604  1.000 18.93158 ? 139 PHE A CZ  1 
ATOM   1153 N  N   . VAL A 1 140 ? -3.56511  5.43383   6.31449   1.000 6.31022  ? 140 VAL A N   1 
ATOM   1154 C  CA  . VAL A 1 140 ? -2.97249  4.19825   5.80521   1.000 5.54081  ? 140 VAL A CA  1 
ATOM   1155 C  C   . VAL A 1 140 ? -1.83496  3.79639   6.73627   1.000 7.57552  ? 140 VAL A C   1 
ATOM   1156 O  O   . VAL A 1 140 ? -1.04998  4.63892   7.17110   1.000 9.69751  ? 140 VAL A O   1 
ATOM   1157 C  CB  . VAL A 1 140 ? -2.47833  4.37126   4.34362   1.000 8.67911  ? 140 VAL A CB  1 
ATOM   1158 C  CG1 . VAL A 1 140 ? -1.61523  3.19214   3.93840   1.000 13.30373 ? 140 VAL A CG1 1 
ATOM   1159 C  CG2 . VAL A 1 140 ? -3.65511  4.53065   3.38380   1.000 11.34013 ? 140 VAL A CG2 1 
ATOM   1160 N  N   . MET A 1 141 ? -1.76855  2.50728   7.07330   1.000 7.60882  ? 141 MET A N   1 
ATOM   1161 C  CA  . MET A 1 141 ? -0.63589  1.92867   7.76159   1.000 8.41595  ? 141 MET A CA  1 
ATOM   1162 C  C   . MET A 1 141 ? -0.00211  0.88343   6.85964   1.000 8.22495  ? 141 MET A C   1 
ATOM   1163 O  O   . MET A 1 141 ? -0.70219  0.00533   6.34471   1.000 8.39078  ? 141 MET A O   1 
ATOM   1164 C  CB  . MET A 1 141 ? -1.09459  1.27438   9.07540   1.000 8.00461  ? 141 MET A CB  1 
ATOM   1165 C  CG  . MET A 1 141 ? -0.00492  0.41261   9.71634   1.000 9.03356  ? 141 MET A CG  1 
ATOM   1166 S  SD  . MET A 1 141 ? -0.61303  -0.16259  11.34445  1.000 11.39951 ? 141 MET A SD  1 
ATOM   1167 C  CE  . MET A 1 141 ? 0.89236   -0.87135  12.04433  1.000 16.63587 ? 141 MET A CE  1 
ATOM   1168 N  N   . ILE A 1 142 ? 1.31015   0.97450   6.65038   1.000 6.84572  ? 142 ILE A N   1 
ATOM   1169 C  CA  . ILE A 1 142 ? 2.03612   -0.03721  5.88043   1.000 6.42134  ? 142 ILE A CA  1 
ATOM   1170 C  C   . ILE A 1 142 ? 3.09707   -0.62475  6.79579   1.000 9.33695  ? 142 ILE A C   1 
ATOM   1171 O  O   . ILE A 1 142 ? 3.99517   0.10425   7.23688   1.000 8.99764  ? 142 ILE A O   1 
ATOM   1172 C  CB  . ILE A 1 142 ? 2.67448   0.57757   4.63294   1.000 8.04612  ? 142 ILE A CB  1 
ATOM   1173 C  CG1 . ILE A 1 142 ? 1.57703   1.06037   3.68576   1.000 10.88704 ? 142 ILE A CG1 1 
ATOM   1174 C  CG2 . ILE A 1 142 ? 3.58726   -0.43012  3.93230   1.000 11.47064 ? 142 ILE A CG2 1 
ATOM   1175 C  CD1 . ILE A 1 142 ? 2.03689   2.27132   2.88816   1.000 15.37024 ? 142 ILE A CD1 1 
ATOM   1176 N  N   . ALA A 1 143 ? 2.99573   -1.92270  7.08848   1.000 7.23619  ? 143 ALA A N   1 
ATOM   1177 C  CA  . ALA A 1 143 ? 3.90411   -2.56626  8.03515   1.000 7.79480  ? 143 ALA A CA  1 
ATOM   1178 C  C   . ALA A 1 143 ? 4.73743   -3.58696  7.29171   1.000 7.92628  ? 143 ALA A C   1 
ATOM   1179 O  O   . ALA A 1 143 ? 4.18487   -4.37193  6.51818   1.000 9.30319  ? 143 ALA A O   1 
ATOM   1180 C  CB  . ALA A 1 143 ? 3.13228   -3.25981  9.16656   1.000 9.32871  ? 143 ALA A CB  1 
ATOM   1181 N  N   . ILE A 1 144 ? 6.05633   -3.61418  7.56086   1.000 7.23726  ? 144 ILE A N   1 
ATOM   1182 C  CA  . ILE A 1 144 ? 6.95849   -4.58471  6.94157   1.000 10.36449 ? 144 ILE A CA  1 
ATOM   1183 C  C   . ILE A 1 144 ? 7.17276   -5.73780  7.90906   1.000 12.27755 ? 144 ILE A C   1 
ATOM   1184 O  O   . ILE A 1 144 ? 7.71209   -5.54194  9.01285   1.000 12.16246 ? 144 ILE A O   1 
ATOM   1185 C  CB  . ILE A 1 144 ? 8.30613   -3.94469  6.60435   1.000 9.33983  ? 144 ILE A CB  1 
ATOM   1186 C  CG1 . ILE A 1 144 ? 8.11090   -2.56389  6.02044   1.000 11.63098 ? 144 ILE A CG1 1 
ATOM   1187 C  CG2 . ILE A 1 144 ? 9.13203   -4.86383  5.68625   1.000 11.25174 ? 144 ILE A CG2 1 
ATOM   1188 C  CD1 . ILE A 1 144 ? 7.35580   -2.55008  4.69487   1.000 12.25428 ? 144 ILE A CD1 1 
ATOM   1189 N  N   . LEU A 1 145 ? 6.78943   -6.93696  7.49523   1.000 10.24582 ? 145 LEU A N   1 
ATOM   1190 C  CA  . LEU A 1 145 ? 6.94686   -8.12749  8.32418   1.000 10.14547 ? 145 LEU A CA  1 
ATOM   1191 C  C   . LEU A 1 145 ? 8.23660   -8.89518  8.05448   1.000 11.97665 ? 145 LEU A C   1 
ATOM   1192 O  O   . LEU A 1 145 ? 8.82896   -9.44784  8.99168   1.000 12.37139 ? 145 LEU A O   1 
ATOM   1193 C  CB  . LEU A 1 145 ? 5.73457   -9.04088  8.12377   1.000 11.74887 ? 145 LEU A CB  1 
ATOM   1194 C  CG  . LEU A 1 145 ? 4.81909   -8.33439  9.12777   1.000 24.39726 ? 145 LEU A CG  1 
ATOM   1195 C  CD1 . LEU A 1 145 ? 3.61039   -7.60472  8.55329   1.000 18.99264 ? 145 LEU A CD1 1 
ATOM   1196 C  CD2 . LEU A 1 145 ? 4.52496   -9.22235  10.33599  1.000 20.96724 ? 145 LEU A CD2 1 
ATOM   1197 N  N   . ASN A 1 146 ? 8.69978   -8.95201  6.80737   1.000 10.25544 ? 146 ASN A N   1 
ATOM   1198 C  CA  . ASN A 1 146 ? 9.85723   -9.76605  6.49563   1.000 10.18110 ? 146 ASN A CA  1 
ATOM   1199 C  C   . ASN A 1 146 ? 10.42609  -9.28453  5.18376   1.000 13.44799 ? 146 ASN A C   1 
ATOM   1200 O  O   . ASN A 1 146 ? 9.67296   -9.03569  4.22629   1.000 12.38821 ? 146 ASN A O   1 
ATOM   1201 C  CB  . ASN A 1 146 ? 9.48054   -11.24678 6.40870   1.000 11.40596 ? 146 ASN A CB  1 
ATOM   1202 C  CG  . ASN A 1 146 ? 10.68714  -12.19260 6.53690   1.000 18.89125 ? 146 ASN A CG  1 
ATOM   1203 O  OD1 . ASN A 1 146 ? 11.80361  -11.76038 6.79136   1.000 21.85906 ? 146 ASN A OD1 1 
ATOM   1204 N  ND2 . ASN A 1 146 ? 10.43727  -13.49205 6.37475   1.000 29.63152 ? 146 ASN A ND2 1 
ATOM   1205 N  N   . LYS A 1 147 ? 11.74984  -9.17301  5.13515   1.000 9.81381  ? 147 LYS A N   1 
ATOM   1206 C  CA  . LYS A 1 147 ? 12.45661  -8.89814  3.89403   1.000 9.14307  ? 147 LYS A CA  1 
ATOM   1207 C  C   . LYS A 1 147 ? 13.57204  -9.91237  3.77662   1.000 16.01549 ? 147 LYS A C   1 
ATOM   1208 O  O   . LYS A 1 147 ? 14.37796  -10.06793 4.70095   1.000 16.48962 ? 147 LYS A O   1 
ATOM   1209 C  CB  . LYS A 1 147 ? 13.02588  -7.46748  3.86356   1.000 10.10088 ? 147 LYS A CB  1 
ATOM   1210 C  CG  . LYS A 1 147 ? 11.92624  -6.45766  3.58636   1.000 12.64942 ? 147 LYS A CG  1 
ATOM   1211 C  CD  . LYS A 1 147 ? 12.44745  -5.05861  3.76416   1.000 13.52691 ? 147 LYS A CD  1 
ATOM   1212 C  CE  . LYS A 1 147 ? 13.43402  -4.68696  2.69800   1.000 16.12170 ? 147 LYS A CE  1 
ATOM   1213 N  NZ  . LYS A 1 147 ? 13.77622  -3.24785  2.79309   1.000 16.96774 ? 147 LYS A NZ  1 
ATOM   1214 N  N   . VAL A 1 148 ? 13.63463  -10.59230 2.64763   1.000 13.03326 ? 148 VAL A N   1 
ATOM   1215 C  CA  . VAL A 1 148 ? 14.66355  -11.60998 2.44181   1.000 15.54184 ? 148 VAL A CA  1 
ATOM   1216 C  C   . VAL A 1 148 ? 15.32462  -11.33383 1.10569   1.000 15.04015 ? 148 VAL A C   1 
ATOM   1217 O  O   . VAL A 1 148 ? 14.65900  -11.39525 0.06671   1.000 12.86020 ? 148 VAL A O   1 
ATOM   1218 C  CB  . VAL A 1 148 ? 14.08357  -13.02814 2.47962   1.000 15.75095 ? 148 VAL A CB  1 
ATOM   1219 C  CG1 . VAL A 1 148 ? 15.14239  -14.05107 2.13731   1.000 20.05156 ? 148 VAL A CG1 1 
ATOM   1220 C  CG2 . VAL A 1 148 ? 13.48234  -13.33359 3.85639   1.000 17.17084 ? 148 VAL A CG2 1 
ATOM   1221 N  N   . ASN A 1 149 ? 16.63484  -11.02989 1.13541   1.000 13.61998 ? 149 ASN A N   1 
ATOM   1222 C  CA  . ASN A 1 149 ? 17.46894  -10.89869 -0.06836  1.000 14.57405 ? 149 ASN A CA  1 
ATOM   1223 C  C   . ASN A 1 149 ? 16.93735  -9.84745  -1.04019  1.000 15.33883 ? 149 ASN A C   1 
ATOM   1224 O  O   . ASN A 1 149 ? 16.98481  -10.02551 -2.26604  1.000 14.66520 ? 149 ASN A O   1 
ATOM   1225 C  CB  . ASN A 1 149 ? 17.60936  -12.23769 -0.77861  1.000 12.19425 ? 149 ASN A CB  1 
ATOM   1226 C  CG  . ASN A 1 149 ? 18.74583  -12.23946 -1.77518  1.000 18.52001 ? 149 ASN A CG  1 
ATOM   1227 O  OD1 . ASN A 1 149 ? 19.79212  -11.63239 -1.53514  1.000 18.53107 ? 149 ASN A OD1 1 
ATOM   1228 N  ND2 . ASN A 1 149 ? 18.53569  -12.89467 -2.91886  1.000 16.67562 ? 149 ASN A ND2 1 
ATOM   1229 N  N   . VAL A 1 150 ? 16.45235  -8.72386  -0.51651  1.000 13.97535 ? 150 VAL A N   1 
ATOM   1230 C  CA  . VAL A 1 150 ? 15.97769  -7.65924  -1.38258  1.000 16.14360 ? 150 VAL A CA  1 
ATOM   1231 C  C   . VAL A 1 150 ? 16.66301  -6.34534  -1.04689  1.000 18.47821 ? 150 VAL A C   1 
ATOM   1232 O  O   . VAL A 1 150 ? 17.17369  -6.13819  0.06138   1.000 20.75526 ? 150 VAL A O   1 
ATOM   1233 C  CB  . VAL A 1 150 ? 14.44027  -7.52321  -1.29724  1.000 11.44673 ? 150 VAL A CB  1 
ATOM   1234 C  CG1 . VAL A 1 150 ? 13.80260  -8.74379  -1.83910  1.000 14.70058 ? 150 VAL A CG1 1 
ATOM   1235 C  CG2 . VAL A 1 150 ? 14.02328  -7.37572  0.14088   1.000 15.47016 ? 150 VAL A CG2 1 
ATOM   1236 N  N   . ALA A 1 151 ? 16.71329  -5.48252  -2.03908  1.000 12.81416 ? 151 ALA A N   1 
ATOM   1237 C  CA  . ALA A 1 151 ? 17.09276  -4.08954  -1.93388  1.000 14.14453 ? 151 ALA A CA  1 
ATOM   1238 C  C   . ALA A 1 151 ? 15.94427  -3.26356  -2.52062  1.000 16.83624 ? 151 ALA A C   1 
ATOM   1239 O  O   . ALA A 1 151 ? 14.89560  -3.81431  -2.86562  1.000 14.48082 ? 151 ALA A O   1 
ATOM   1240 C  CB  . ALA A 1 151 ? 18.42730  -3.85175  -2.64450  1.000 23.34952 ? 151 ALA A CB  1 
ATOM   1241 N  N   . GLY A 1 152 ? 16.14883  -1.94991  -2.64413  1.000 17.59475 ? 152 GLY A N   1 
ATOM   1242 C  CA  . GLY A 1 152 ? 15.06589  -1.08534  -3.13858  1.000 14.88784 ? 152 GLY A CA  1 
ATOM   1243 C  C   . GLY A 1 152 ? 13.91398  -1.04885  -2.14459  1.000 16.11183 ? 152 GLY A C   1 
ATOM   1244 O  O   . GLY A 1 152 ? 14.10033  -1.21811  -0.93441  1.000 14.20153 ? 152 GLY A O   1 
ATOM   1245 N  N   . GLY A 1 153 ? 12.69860  -0.83897  -2.66232  1.000 13.37974 ? 153 GLY A N   1 
ATOM   1246 C  CA  . GLY A 1 153 ? 11.53221  -0.75143  -1.79521  1.000 11.42430 ? 153 GLY A CA  1 
ATOM   1247 C  C   . GLY A 1 153 ? 11.60802  0.44794   -0.86778  1.000 9.40432  ? 153 GLY A C   1 
ATOM   1248 O  O   . GLY A 1 153 ? 11.33651  0.37240   0.33502   1.000 11.45313 ? 153 GLY A O   1 
ATOM   1249 N  N   . THR A 1 154 ? 11.93995  1.59603   -1.43172  1.000 9.96468  ? 154 THR A N   1 
ATOM   1250 C  CA  . THR A 1 154 ? 12.05722  2.83443   -0.68221  1.000 11.42531 ? 154 THR A CA  1 
ATOM   1251 C  C   . THR A 1 154 ? 10.75265  3.60696   -0.79373  1.000 10.32187 ? 154 THR A C   1 
ATOM   1252 O  O   . THR A 1 154 ? 10.33553  3.95085   -1.90545  1.000 9.17096  ? 154 THR A O   1 
ATOM   1253 C  CB  . THR A 1 154 ? 13.20708  3.68597   -1.22029  1.000 13.75689 ? 154 THR A CB  1 
ATOM   1254 O  OG1 . THR A 1 154 ? 14.41946  2.91613   -1.13920  1.000 15.39366 ? 154 THR A OG1 1 
ATOM   1255 C  CG2 . THR A 1 154 ? 13.32687  4.96066   -0.41382  1.000 16.15732 ? 154 THR A CG2 1 
ATOM   1256 N  N   . THR A 1 155 ? 10.13679  3.86737   0.34976   1.000 8.49708  ? 155 THR A N   1 
ATOM   1257 C  CA  . THR A 1 155 ? 8.93279   4.68984   0.45147   1.000 9.27330  ? 155 THR A CA  1 
ATOM   1258 C  C   . THR A 1 155 ? 9.26953   6.16172   0.22899   1.000 10.04973 ? 155 THR A C   1 
ATOM   1259 O  O   . THR A 1 155 ? 10.22008  6.68812   0.81720   1.000 10.08464 ? 155 THR A O   1 
ATOM   1260 C  CB  . THR A 1 155 ? 8.31445   4.50967   1.82737   1.000 8.69130  ? 155 THR A CB  1 
ATOM   1261 O  OG1 . THR A 1 155 ? 8.01723   3.11117   2.01925   1.000 11.32065 ? 155 THR A OG1 1 
ATOM   1262 C  CG2 . THR A 1 155 ? 7.00792   5.35081   1.92852   1.000 9.56088  ? 155 THR A CG2 1 
ATOM   1263 N  N   . ARG A 1 156 ? 8.45394   6.84382   -0.58828  1.000 7.52243  ? 156 ARG A N   1 
ATOM   1264 C  CA  . ARG A 1 156 ? 8.63794   8.26237   -0.85304  1.000 7.26688  ? 156 ARG A CA  1 
ATOM   1265 C  C   . ARG A 1 156 ? 7.30273   8.95582   -0.59629  1.000 8.12375  ? 156 ARG A C   1 
ATOM   1266 O  O   . ARG A 1 156 ? 6.25139   8.47640   -1.04926  1.000 8.11369  ? 156 ARG A O   1 
ATOM   1267 C  CB  . ARG A 1 156 ? 9.12949   8.49833   -2.26513  1.000 9.64756  ? 156 ARG A CB  1 
ATOM   1268 C  CG  . ARG A 1 156 ? 10.43486  7.74232   -2.52278  1.000 13.74955 ? 156 ARG A CG  1 
ATOM   1269 C  CD  . ARG A 1 156 ? 10.98520  7.96969   -3.86376  1.000 24.25466 ? 156 ARG A CD  1 
ATOM   1270 N  NE  . ARG A 1 156 ? 10.07603  7.60175   -4.93534  1.000 13.88911 ? 156 ARG A NE  1 
ATOM   1271 C  CZ  . ARG A 1 156 ? 10.45468  7.62498   -6.19723  1.000 19.90776 ? 156 ARG A CZ  1 
ATOM   1272 N  NH1 . ARG A 1 156 ? 11.71319  7.88352   -6.52311  1.000 25.79440 ? 156 ARG A NH1 1 
ATOM   1273 N  NH2 . ARG A 1 156 ? 9.56147   7.39648   -7.14908  1.000 20.88441 ? 156 ARG A NH2 1 
ATOM   1274 N  N   . LEU A 1 157 ? 7.33963   10.05163  0.16530   1.000 7.46030  ? 157 LEU A N   1 
ATOM   1275 C  CA  . LEU A 1 157 ? 6.11841   10.78163  0.48413   1.000 7.41415  ? 157 LEU A CA  1 
ATOM   1276 C  C   . LEU A 1 157 ? 6.15923   12.14060  -0.21155  1.000 8.63558  ? 157 LEU A C   1 
ATOM   1277 O  O   . LEU A 1 157 ? 7.20886   12.78267  -0.26922  1.000 10.67626 ? 157 LEU A O   1 
ATOM   1278 C  CB  . LEU A 1 157 ? 5.96421   10.94297  2.00731   1.000 7.94158  ? 157 LEU A CB  1 
ATOM   1279 C  CG  . LEU A 1 157 ? 5.99130   9.62927   2.79973   1.000 10.77749 ? 157 LEU A CG  1 
ATOM   1280 C  CD1 . LEU A 1 157 ? 5.81470   9.94522   4.27983   1.000 11.43996 ? 157 LEU A CD1 1 
ATOM   1281 C  CD2 . LEU A 1 157 ? 4.90124   8.73152   2.30281   1.000 10.26242 ? 157 LEU A CD2 1 
ATOM   1282 N  N   . TRP A 1 158 ? 5.01484   12.56794  -0.71416  1.000 8.73058  ? 158 TRP A N   1 
ATOM   1283 C  CA  . TRP A 1 158 ? 4.92136   13.69774  -1.62512  1.000 7.86231  ? 158 TRP A CA  1 
ATOM   1284 C  C   . TRP A 1 158 ? 3.83072   14.64213  -1.16702  1.000 9.89011  ? 158 TRP A C   1 
ATOM   1285 O  O   . TRP A 1 158 ? 2.72696   14.21714  -0.81758  1.000 10.93771 ? 158 TRP A O   1 
ATOM   1286 C  CB  . TRP A 1 158 ? 4.56661   13.23497  -3.03121  1.000 8.55822  ? 158 TRP A CB  1 
ATOM   1287 C  CG  . TRP A 1 158 ? 5.45742   12.18359  -3.64838  1.000 9.55168  ? 158 TRP A CG  1 
ATOM   1288 C  CD1 . TRP A 1 158 ? 5.61838   10.86236  -3.23277  1.000 7.61638  ? 158 TRP A CD1 1 
ATOM   1289 C  CD2 . TRP A 1 158 ? 6.25333   12.32628  -4.82899  1.000 10.75898 ? 158 TRP A CD2 1 
ATOM   1290 N  NE1 . TRP A 1 158 ? 6.49381   10.21828  -4.07704  1.000 7.53850  ? 158 TRP A NE1 1 
ATOM   1291 C  CE2 . TRP A 1 158 ? 6.88631   11.08434  -5.06443  1.000 9.27279  ? 158 TRP A CE2 1 
ATOM   1292 C  CE3 . TRP A 1 158 ? 6.49191   13.38266  -5.71039  1.000 14.90189 ? 158 TRP A CE3 1 
ATOM   1293 C  CZ2 . TRP A 1 158 ? 7.74426   10.88129  -6.12688  1.000 13.79325 ? 158 TRP A CZ2 1 
ATOM   1294 C  CZ3 . TRP A 1 158 ? 7.33674   13.17493  -6.77366  1.000 16.17538 ? 158 TRP A CZ3 1 
ATOM   1295 C  CH2 . TRP A 1 158 ? 7.96968   11.94343  -6.96340  1.000 14.66009 ? 158 TRP A CH2 1 
ATOM   1296 N  N   . LYS A 1 159 ? 4.11087   15.93808  -1.21412  1.000 9.74616  ? 159 LYS A N   1 
ATOM   1297 C  CA  . LYS A 1 159 ? 3.02844   16.88446  -1.04483  1.000 11.09611 ? 159 LYS A CA  1 
ATOM   1298 C  C   . LYS A 1 159 ? 2.14825   16.86418  -2.29075  1.000 12.69122 ? 159 LYS A C   1 
ATOM   1299 O  O   . LYS A 1 159 ? 2.62805   16.58033  -3.39409  1.000 12.60018 ? 159 LYS A O   1 
ATOM   1300 C  CB  . LYS A 1 159 ? 3.59421   18.28246  -0.80661  1.000 10.97914 ? 159 LYS A CB  1 
ATOM   1301 C  CG  . LYS A 1 159 ? 4.50575   18.37248  0.38669   1.000 17.27192 ? 159 LYS A CG  1 
ATOM   1302 C  CD  . LYS A 1 159 ? 3.76243   18.17362  1.68481   1.000 20.44944 ? 159 LYS A CD  1 
ATOM   1303 C  CE  . LYS A 1 159 ? 4.72620   18.43369  2.84395   1.000 28.05197 ? 159 LYS A CE  1 
ATOM   1304 N  NZ  . LYS A 1 159 ? 4.04587   18.61951  4.16097   1.000 38.87089 ? 159 LYS A NZ  1 
ATOM   1305 N  N   . PRO A 1 160 ? 0.85947   17.15991  -2.15855  1.000 13.05468 ? 160 PRO A N   1 
ATOM   1306 C  CA  . PRO A 1 160 ? -0.01562  17.07026  -3.33298  1.000 18.34478 ? 160 PRO A CA  1 
ATOM   1307 C  C   . PRO A 1 160 ? 0.48823   17.94328  -4.47744  1.000 13.79748 ? 160 PRO A C   1 
ATOM   1308 O  O   . PRO A 1 160 ? 0.83766   19.11872  -4.30215  1.000 17.65463 ? 160 PRO A O   1 
ATOM   1309 C  CB  . PRO A 1 160 ? -1.37332  17.53443  -2.79134  1.000 25.53386 ? 160 PRO A CB  1 
ATOM   1310 C  CG  . PRO A 1 160 ? -1.29261  17.16874  -1.31284  1.000 23.51465 ? 160 PRO A CG  1 
ATOM   1311 C  CD  . PRO A 1 160 ? 0.10960   17.56122  -0.96281  1.000 20.06387 ? 160 PRO A CD  1 
ATOM   1312 N  N   . GLY A 1 161 ? 0.60427   17.32503  -5.64927  1.000 17.32662 ? 161 GLY A N   1 
ATOM   1313 C  CA  . GLY A 1 161 ? 1.03558   18.02008  -6.84518  1.000 11.96319 ? 161 GLY A CA  1 
ATOM   1314 C  C   . GLY A 1 161 ? 2.52227   18.28404  -6.96982  1.000 11.55570 ? 161 GLY A C   1 
ATOM   1315 O  O   . GLY A 1 161 ? 2.94491   18.83806  -7.98800  1.000 15.05438 ? 161 GLY A O   1 
ATOM   1316 N  N   . ALA A 1 162 ? 3.34135   17.91970  -5.98061  1.000 10.55638 ? 162 ALA A N   1 
ATOM   1317 C  CA  . ALA A 1 162 ? 4.77098   18.21541  -6.01942  1.000 10.68088 ? 162 ALA A CA  1 
ATOM   1318 C  C   . ALA A 1 162 ? 5.48611   17.38231  -7.06934  1.000 12.90331 ? 162 ALA A C   1 
ATOM   1319 O  O   . ALA A 1 162 ? 5.02346   16.29976  -7.44338  1.000 16.22578 ? 162 ALA A O   1 
ATOM   1320 C  CB  . ALA A 1 162 ? 5.42653   17.93661  -4.66586  1.000 11.18802 ? 162 ALA A CB  1 
ATOM   1321 N  N   . ASP A 1 163 ? 6.62745   17.88964  -7.54761  1.000 13.29919 ? 163 ASP A N   1 
ATOM   1322 C  CA  . ASP A 1 163 ? 7.35358   17.12623  -8.55063  1.000 16.66341 ? 163 ASP A CA  1 
ATOM   1323 C  C   . ASP A 1 163 ? 8.51641   16.33658  -7.96052  1.000 15.20464 ? 163 ASP A C   1 
ATOM   1324 O  O   . ASP A 1 163 ? 9.22013   15.63717  -8.69242  1.000 15.47238 ? 163 ASP A O   1 
ATOM   1325 C  CB  . ASP A 1 163 ? 7.84881   18.04670  -9.67283  1.000 24.54861 ? 163 ASP A CB  1 
ATOM   1326 C  CG  . ASP A 1 163 ? 8.86766   19.06005  -9.20387  1.000 24.07531 ? 163 ASP A CG  1 
ATOM   1327 O  OD1 . ASP A 1 163 ? 9.16510   19.14907  -7.99435  1.000 35.80700 ? 163 ASP A OD1 1 
ATOM   1328 O  OD2 . ASP A 1 163 ? 9.38712   19.79636  -10.07667 1.000 43.55038 ? 163 ASP A OD2 1 
ATOM   1329 N  N   . ALA A 1 164 ? 8.72035   16.42078  -6.66239  1.000 14.66433 ? 164 ALA A N   1 
ATOM   1330 C  CA  . ALA A 1 164 ? 9.72202   15.62688  -5.97206  1.000 15.19968 ? 164 ALA A CA  1 
ATOM   1331 C  C   . ALA A 1 164 ? 9.18572   15.29757  -4.59294  1.000 12.17364 ? 164 ALA A C   1 
ATOM   1332 O  O   . ALA A 1 164 ? 8.40022   16.06512  -4.03638  1.000 12.62834 ? 164 ALA A O   1 
ATOM   1333 C  CB  . ALA A 1 164 ? 11.05636  16.37266  -5.85389  1.000 19.39744 ? 164 ALA A CB  1 
ATOM   1334 N  N   . PRO A 1 165 ? 9.59383   14.17310  -4.01431  1.000 12.10464 ? 165 PRO A N   1 
ATOM   1335 C  CA  . PRO A 1 165 ? 9.15320   13.84934  -2.65152  1.000 10.72300 ? 165 PRO A CA  1 
ATOM   1336 C  C   . PRO A 1 165 ? 9.83749   14.71245  -1.60845  1.000 13.10317 ? 165 PRO A C   1 
ATOM   1337 O  O   . PRO A 1 165 ? 10.94066  15.22876  -1.82078  1.000 18.88690 ? 165 PRO A O   1 
ATOM   1338 C  CB  . PRO A 1 165 ? 9.55670   12.37794  -2.48872  1.000 10.44256 ? 165 PRO A CB  1 
ATOM   1339 C  CG  . PRO A 1 165 ? 10.74318  12.23510  -3.40304  1.000 13.14399 ? 165 PRO A CG  1 
ATOM   1340 C  CD  . PRO A 1 165 ? 10.43228  13.12175  -4.60540  1.000 14.00558 ? 165 PRO A CD  1 
ATOM   1341 N  N   . PHE A 1 166 ? 9.17508   14.87793  -0.46436  1.000 11.32880 ? 166 PHE A N   1 
ATOM   1342 C  CA  . PHE A 1 166 ? 9.82313   15.62117  0.62027   1.000 12.53691 ? 166 PHE A CA  1 
ATOM   1343 C  C   . PHE A 1 166 ? 10.45019  14.72435  1.66766   1.000 16.25538 ? 166 PHE A C   1 
ATOM   1344 O  O   . PHE A 1 166 ? 11.23339  15.21398  2.49171   1.000 18.85254 ? 166 PHE A O   1 
ATOM   1345 C  CB  . PHE A 1 166 ? 8.84283   16.58289  1.29803   1.000 16.21439 ? 166 PHE A CB  1 
ATOM   1346 C  CG  . PHE A 1 166 ? 7.78451   15.90574  2.12904   1.000 12.64948 ? 166 PHE A CG  1 
ATOM   1347 C  CD1 . PHE A 1 166 ? 6.61474   15.44295  1.53072   1.000 15.00437 ? 166 PHE A CD1 1 
ATOM   1348 C  CD2 . PHE A 1 166 ? 7.94944   15.73785  3.49337   1.000 17.13320 ? 166 PHE A CD2 1 
ATOM   1349 C  CE1 . PHE A 1 166 ? 5.61925   14.81650  2.28942   1.000 13.21163 ? 166 PHE A CE1 1 
ATOM   1350 C  CE2 . PHE A 1 166 ? 6.96737   15.11356  4.27136   1.000 21.20866 ? 166 PHE A CE2 1 
ATOM   1351 C  CZ  . PHE A 1 166 ? 5.79699   14.64650  3.67151   1.000 17.49636 ? 166 PHE A CZ  1 
ATOM   1352 N  N   . TRP A 1 167 ? 10.12838  13.43540  1.66446   1.000 13.89767 ? 167 TRP A N   1 
ATOM   1353 C  CA  . TRP A 1 167 ? 10.72756  12.47250  2.58108   1.000 11.67520 ? 167 TRP A CA  1 
ATOM   1354 C  C   . TRP A 1 167 ? 10.86908  11.14811  1.85224   1.000 13.46729 ? 167 TRP A C   1 
ATOM   1355 O  O   . TRP A 1 167 ? 9.99138   10.76941  1.08040   1.000 10.42678 ? 167 TRP A O   1 
ATOM   1356 C  CB  . TRP A 1 167 ? 9.88507   12.30704  3.85687   1.000 14.41723 ? 167 TRP A CB  1 
ATOM   1357 C  CG  . TRP A 1 167 ? 10.42507  11.32722  4.87594   1.000 16.53851 ? 167 TRP A CG  1 
ATOM   1358 C  CD1 . TRP A 1 167 ? 11.20693  11.62033  5.95497   1.000 19.78037 ? 167 TRP A CD1 1 
ATOM   1359 C  CD2 . TRP A 1 167 ? 10.18361  9.91075   4.92865   1.000 13.18038 ? 167 TRP A CD2 1 
ATOM   1360 N  NE1 . TRP A 1 167 ? 11.48253  10.47012  6.67226   1.000 17.27161 ? 167 TRP A NE1 1 
ATOM   1361 C  CE2 . TRP A 1 167 ? 10.86859  9.40925   6.05646   1.000 15.31862 ? 167 TRP A CE2 1 
ATOM   1362 C  CE3 . TRP A 1 167 ? 9.46799   9.02063   4.13205   1.000 14.47756 ? 167 TRP A CE3 1 
ATOM   1363 C  CZ2 . TRP A 1 167 ? 10.85103  8.05247   6.39924   1.000 13.82938 ? 167 TRP A CZ2 1 
ATOM   1364 C  CZ3 . TRP A 1 167 ? 9.45275   7.68109   4.48048   1.000 17.15564 ? 167 TRP A CZ3 1 
ATOM   1365 C  CH2 . TRP A 1 167 ? 10.13959  7.21448   5.60354   1.000 15.12994 ? 167 TRP A CH2 1 
ATOM   1366 N  N   . SER A 1 168 ? 11.97678  10.44070  2.11443   1.000 10.85546 ? 168 SER A N   1 
ATOM   1367 C  CA  . SER A 1 168 ? 12.21944  9.13454   1.53764   1.000 10.12951 ? 168 SER A CA  1 
ATOM   1368 C  C   . SER A 1 168 ? 12.82448  8.27564   2.63276   1.000 14.67268 ? 168 SER A C   1 
ATOM   1369 O  O   . SER A 1 168 ? 13.62486  8.76590   3.44214   1.000 18.13212 ? 168 SER A O   1 
ATOM   1370 C  CB  . SER A 1 168 ? 13.18786  9.19940   0.34373   1.000 14.94059 ? 168 SER A CB  1 
ATOM   1371 O  OG  . SER A 1 168 ? 12.61195  9.91360   -0.73882  1.000 28.37115 ? 168 SER A OG  1 
ATOM   1372 N  N   . GLY A 1 169 ? 12.45512  6.99966   2.64756   1.000 13.23732 ? 169 GLY A N   1 
ATOM   1373 C  CA  . GLY A 1 169 ? 13.06854  6.09475   3.61537   1.000 10.49009 ? 169 GLY A CA  1 
ATOM   1374 C  C   . GLY A 1 169 ? 12.72183  4.68086   3.25687   1.000 12.21397 ? 169 GLY A C   1 
ATOM   1375 O  O   . GLY A 1 169 ? 11.61789  4.40354   2.77550   1.000 10.57800 ? 169 GLY A O   1 
ATOM   1376 N  N   . THR A 1 170 ? 13.64968  3.76639   3.46836   1.000 12.18255 ? 170 THR A N   1 
ATOM   1377 C  CA  . THR A 1 170 ? 13.42529  2.35229   3.19883   1.000 11.68750 ? 170 THR A CA  1 
ATOM   1378 C  C   . THR A 1 170 ? 12.99434  1.68547   4.48707   1.000 13.92270 ? 170 THR A C   1 
ATOM   1379 O  O   . THR A 1 170 ? 13.79818  1.55033   5.42257   1.000 13.68797 ? 170 THR A O   1 
ATOM   1380 C  CB  . THR A 1 170 ? 14.68182  1.68612   2.67669   1.000 12.29275 ? 170 THR A CB  1 
ATOM   1381 O  OG1 . THR A 1 170 ? 15.09937  2.40396   1.51635   1.000 13.35247 ? 170 THR A OG1 1 
ATOM   1382 C  CG2 . THR A 1 170 ? 14.39097  0.24403   2.33805   1.000 11.53452 ? 170 THR A CG2 1 
ATOM   1383 N  N   . LEU A 1 171 ? 11.72313  1.31574   4.56253   1.000 11.52025 ? 171 LEU A N   1 
ATOM   1384 C  CA  . LEU A 1 171 ? 11.23602  0.65521   5.76261   1.000 8.46660  ? 171 LEU A CA  1 
ATOM   1385 C  C   . LEU A 1 171 ? 11.79613  -0.75520  5.82324   1.000 8.50648  ? 171 LEU A C   1 
ATOM   1386 O  O   . LEU A 1 171 ? 11.75849  -1.50611  4.84437   1.000 12.30565 ? 171 LEU A O   1 
ATOM   1387 C  CB  . LEU A 1 171 ? 9.70748   0.62367   5.77899   1.000 9.65464  ? 171 LEU A CB  1 
ATOM   1388 C  CG  . LEU A 1 171 ? 9.07666   2.02099   5.72819   1.000 13.47293 ? 171 LEU A CG  1 
ATOM   1389 C  CD1 . LEU A 1 171 ? 7.57812   1.89897   5.55451   1.000 13.66357 ? 171 LEU A CD1 1 
ATOM   1390 C  CD2 . LEU A 1 171 ? 9.38447   2.76789   7.02831   1.000 16.88818 ? 171 LEU A CD2 1 
ATOM   1391 N  N   . GLU A 1 172 ? 12.27920  -1.14195  7.00072   1.000 11.22191 ? 172 GLU A N   1 
ATOM   1392 C  CA  . GLU A 1 172 ? 12.82147  -2.48144  7.21301   1.000 10.57478 ? 172 GLU A CA  1 
ATOM   1393 C  C   . GLU A 1 172 ? 11.82121  -3.35800  7.96172   1.000 7.78526  ? 172 GLU A C   1 
ATOM   1394 O  O   . GLU A 1 172 ? 10.84745  -2.86762  8.53820   1.000 9.71492  ? 172 GLU A O   1 
ATOM   1395 C  CB  . GLU A 1 172 ? 14.14097  -2.39967  7.99895   1.000 9.19017  ? 172 GLU A CB  1 
ATOM   1396 C  CG  . GLU A 1 172 ? 15.16591  -1.45828  7.39129   1.000 11.66981 ? 172 GLU A CG  1 
ATOM   1397 C  CD  . GLU A 1 172 ? 15.51259  -1.82052  5.93903   1.000 12.75164 ? 172 GLU A CD  1 
ATOM   1398 O  OE1 . GLU A 1 172 ? 15.18626  -2.93227  5.46080   1.000 12.64585 ? 172 GLU A OE1 1 
ATOM   1399 O  OE2 . GLU A 1 172 ? 16.14754  -0.97546  5.26825   1.000 15.15021 ? 172 GLU A OE2 1 
ATOM   1400 N  N   . ALA A 1 173 ? 12.09179  -4.67525  7.96166   1.000 11.06463 ? 173 ALA A N   1 
ATOM   1401 C  CA  . ALA A 1 173 ? 11.26566  -5.61166  8.71697   1.000 9.78420  ? 173 ALA A CA  1 
ATOM   1402 C  C   . ALA A 1 173 ? 11.16454  -5.15936  10.16472  1.000 11.78071 ? 173 ALA A C   1 
ATOM   1403 O  O   . ALA A 1 173 ? 12.17178  -4.78340  10.77867  1.000 13.76809 ? 173 ALA A O   1 
ATOM   1404 C  CB  . ALA A 1 173 ? 11.84982  -7.02319  8.61709   1.000 12.58179 ? 173 ALA A CB  1 
ATOM   1405 N  N   . GLY A 1 174 ? 9.94220   -5.13659  10.69148  1.000 9.87492  ? 174 GLY A N   1 
ATOM   1406 C  CA  . GLY A 1 174 ? 9.71330   -4.61623  12.03829  1.000 10.28108 ? 174 GLY A CA  1 
ATOM   1407 C  C   . GLY A 1 174 ? 9.38593   -3.13716  12.13217  1.000 15.34092 ? 174 GLY A C   1 
ATOM   1408 O  O   . GLY A 1 174 ? 9.24095   -2.61609  13.25471  1.000 16.50980 ? 174 GLY A O   1 
ATOM   1409 N  N   . GLN A 1 175 ? 9.25491   -2.43985  11.00380  1.000 10.54912 ? 175 GLN A N   1 
ATOM   1410 C  CA  . GLN A 1 175 ? 8.85949   -1.03370  10.98441  1.000 10.26463 ? 175 GLN A CA  1 
ATOM   1411 C  C   . GLN A 1 175 ? 7.53020   -0.87529  10.25330  1.000 10.06907 ? 175 GLN A C   1 
ATOM   1412 O  O   . GLN A 1 175 ? 7.15833   -1.71149  9.42219   1.000 9.77021  ? 175 GLN A O   1 
ATOM   1413 C  CB  . GLN A 1 175 ? 9.89987   -0.17665  10.28462  1.000 10.12008 ? 175 GLN A CB  1 
ATOM   1414 C  CG  . GLN A 1 175 ? 11.28669  -0.23799  10.90479  1.000 14.63988 ? 175 GLN A CG  1 
ATOM   1415 C  CD  . GLN A 1 175 ? 12.16845  0.81936   10.29890  1.000 19.07627 ? 175 GLN A CD  1 
ATOM   1416 O  OE1 . GLN A 1 175 ? 12.61708  0.70724   9.14805   1.000 15.87426 ? 175 GLN A OE1 1 
ATOM   1417 N  NE2 . GLN A 1 175 ? 12.40081  1.88372   11.05963  1.000 25.26273 ? 175 GLN A NE2 1 
ATOM   1418 N  N   . ALA A 1 176 ? 6.83142   0.19959   10.57231  1.000 11.03217 ? 176 ALA A N   1 
ATOM   1419 C  CA  . ALA A 1 176 ? 5.60601   0.55950   9.86193   1.000 11.05268 ? 176 ALA A CA  1 
ATOM   1420 C  C   . ALA A 1 176 ? 5.55802   2.06242   9.68878   1.000 11.45923 ? 176 ALA A C   1 
ATOM   1421 O  O   . ALA A 1 176 ? 6.08477   2.81690   10.51907  1.000 9.71798  ? 176 ALA A O   1 
ATOM   1422 C  CB  . ALA A 1 176 ? 4.32919   0.09867   10.58812  1.000 12.62185 ? 176 ALA A CB  1 
ATOM   1423 N  N   . VAL A 1 177 ? 4.93519   2.50962   8.58372   1.000 9.78959  ? 177 VAL A N   1 
ATOM   1424 C  CA  . VAL A 1 177 ? 4.65116   3.92668   8.42140   1.000 10.10480 ? 177 VAL A CA  1 
ATOM   1425 C  C   . VAL A 1 177 ? 3.13732   4.14830   8.52226   1.000 10.60990 ? 177 VAL A C   1 
ATOM   1426 O  O   . VAL A 1 177 ? 2.33032   3.33028   8.04433   1.000 8.69816  ? 177 VAL A O   1 
ATOM   1427 C  CB  . VAL A 1 177 ? 5.24574   4.46226   7.10737   1.000 10.25358 ? 177 VAL A CB  1 
ATOM   1428 C  CG1 . VAL A 1 177 ? 4.54870   3.84277   5.88301   1.000 11.92249 ? 177 VAL A CG1 1 
ATOM   1429 C  CG2 . VAL A 1 177 ? 5.12765   5.99351   7.06820   1.000 11.84255 ? 177 VAL A CG2 1 
ATOM   1430 N  N   . LEU A 1 178 ? 2.76001   5.19347   9.23994   1.000 9.91028  ? 178 LEU A N   1 
ATOM   1431 C  CA  . LEU A 1 178 ? 1.38574   5.64957   9.35643   1.000 9.14849  ? 178 LEU A CA  1 
ATOM   1432 C  C   . LEU A 1 178 ? 1.28683   6.95972   8.57784   1.000 9.46323  ? 178 LEU A C   1 
ATOM   1433 O  O   . LEU A 1 178 ? 2.13788   7.83209   8.74541   1.000 11.02547 ? 178 LEU A O   1 
ATOM   1434 C  CB  . LEU A 1 178 ? 1.01575   5.87119   10.83121  1.000 8.56542  ? 178 LEU A CB  1 
ATOM   1435 C  CG  . LEU A 1 178 ? 1.28577   4.57163   11.60580  1.000 15.69815 ? 178 LEU A CG  1 
ATOM   1436 C  CD1 . LEU A 1 178 ? 1.51676   4.83202   13.07118  1.000 22.66008 ? 178 LEU A CD1 1 
ATOM   1437 C  CD2 . LEU A 1 178 ? 0.07518   3.65492   11.41190  1.000 21.78145 ? 178 LEU A CD2 1 
ATOM   1438 N  N   A LEU A 1 179 ? 0.28684   7.11229   7.72112   0.389 8.95119  ? 179 LEU A N   1 
ATOM   1439 N  N   B LEU A 1 179 ? 0.24650   7.09274   7.73823   0.611 8.93105  ? 179 LEU A N   1 
ATOM   1440 C  CA  A LEU A 1 179 ? 0.27245   8.34401   6.94499   0.389 8.10638  ? 179 LEU A CA  1 
ATOM   1441 C  CA  B LEU A 1 179 ? 0.11962   8.18365   6.76885   0.611 8.17454  ? 179 LEU A CA  1 
ATOM   1442 C  C   A LEU A 1 179 ? -1.13687  8.87870   6.77061   0.389 9.53536  ? 179 LEU A C   1 
ATOM   1443 C  C   B LEU A 1 179 ? -1.22924  8.87661   6.86148   0.611 9.55693  ? 179 LEU A C   1 
ATOM   1444 O  O   A LEU A 1 179 ? -2.11492  8.13162   6.65534   0.389 8.42247  ? 179 LEU A O   1 
ATOM   1445 O  O   B LEU A 1 179 ? -2.27363  8.22575   6.97337   0.611 8.48135  ? 179 LEU A O   1 
ATOM   1446 C  CB  A LEU A 1 179 ? 0.94388   8.16497   5.57359   0.389 9.53698  ? 179 LEU A CB  1 
ATOM   1447 C  CB  B LEU A 1 179 ? 0.26307   7.68305   5.30593   0.611 9.37012  ? 179 LEU A CB  1 
ATOM   1448 C  CG  A LEU A 1 179 ? 0.37557   7.10563   4.63418   0.389 10.46892 ? 179 LEU A CG  1 
ATOM   1449 C  CG  B LEU A 1 179 ? 1.54438   6.94549   4.96686   0.611 9.18339  ? 179 LEU A CG  1 
ATOM   1450 C  CD1 A LEU A 1 179 ? -0.78403  7.63936   3.80937   0.389 10.16321 ? 179 LEU A CD1 1 
ATOM   1451 C  CD1 B LEU A 1 179 ? 1.49513   6.46901   3.51838   0.611 13.64121 ? 179 LEU A CD1 1 
ATOM   1452 C  CD2 A LEU A 1 179 ? 1.45854   6.54640   3.71219   0.389 13.54786 ? 179 LEU A CD2 1 
ATOM   1453 C  CD2 B LEU A 1 179 ? 2.70677   7.91061   5.19356   0.611 8.46240  ? 179 LEU A CD2 1 
ATOM   1454 N  N   . ASP A 1 180 ? -1.20473  10.20481  6.74153   1.000 8.81301  ? 180 ASP A N   1 
ATOM   1455 C  CA  . ASP A 1 180 ? -2.39422  10.95475  6.40322   1.000 10.09894 ? 180 ASP A CA  1 
ATOM   1456 C  C   . ASP A 1 180 ? -2.59566  10.80934  4.90640   1.000 12.63411 ? 180 ASP A C   1 
ATOM   1457 O  O   . ASP A 1 180 ? -1.93027  11.47433  4.10882   1.000 12.91796 ? 180 ASP A O   1 
ATOM   1458 C  CB  . ASP A 1 180 ? -2.18401  12.40463  6.82236   1.000 12.02402 ? 180 ASP A CB  1 
ATOM   1459 C  CG  . ASP A 1 180 ? -3.16876  13.35614  6.16532   1.000 15.65283 ? 180 ASP A CG  1 
ATOM   1460 O  OD1 . ASP A 1 180 ? -4.17365  12.92526  5.58525   1.000 12.25711 ? 180 ASP A OD1 1 
ATOM   1461 O  OD2 . ASP A 1 180 ? -2.92390  14.59491  6.22321   1.000 23.51385 ? 180 ASP A OD2 1 
ATOM   1462 N  N   . ASP A 1 181 ? -3.51616  9.93652   4.51006   1.000 9.30108  ? 181 ASP A N   1 
ATOM   1463 C  CA  . ASP A 1 181 ? -3.64371  9.57003   3.10863   1.000 9.01165  ? 181 ASP A CA  1 
ATOM   1464 C  C   . ASP A 1 181 ? -4.36257  10.62145  2.27329   1.000 12.62815 ? 181 ASP A C   1 
ATOM   1465 O  O   . ASP A 1 181 ? -4.40706  10.49668  1.03890   1.000 11.33692 ? 181 ASP A O   1 
ATOM   1466 C  CB  . ASP A 1 181 ? -4.35434  8.19934   3.06869   1.000 11.29627 ? 181 ASP A CB  1 
ATOM   1467 C  CG  . ASP A 1 181 ? -4.44269  7.58095   1.65964   1.000 13.18452 ? 181 ASP A CG  1 
ATOM   1468 O  OD1 . ASP A 1 181 ? -3.42941  7.50105   0.90743   1.000 12.04013 ? 181 ASP A OD1 1 
ATOM   1469 O  OD2 . ASP A 1 181 ? -5.54828  7.12836   1.34210   1.000 13.88847 ? 181 ASP A OD2 1 
ATOM   1470 N  N   . ARG A 1 182 ? -4.90600  11.66209  2.91416   1.000 10.80944 ? 182 ARG A N   1 
ATOM   1471 C  CA  . ARG A 1 182 ? -5.49171  12.78864  2.20333   1.000 13.80637 ? 182 ARG A CA  1 
ATOM   1472 C  C   . ARG A 1 182 ? -4.48417  13.90671  1.98875   1.000 11.28075 ? 182 ARG A C   1 
ATOM   1473 O  O   . ARG A 1 182 ? -4.41758  14.46384  0.88306   1.000 16.31818 ? 182 ARG A O   1 
ATOM   1474 C  CB  . ARG A 1 182 ? -6.72144  13.28697  2.97946   1.000 13.44546 ? 182 ARG A CB  1 
ATOM   1475 C  CG  . ARG A 1 182 ? -7.82547  12.27766  2.92001   1.000 13.35393 ? 182 ARG A CG  1 
ATOM   1476 C  CD  . ARG A 1 182 ? -8.98564  12.60829  3.84744   1.000 12.60289 ? 182 ARG A CD  1 
ATOM   1477 N  NE  . ARG A 1 182 ? -10.05947 11.63210  3.67672   1.000 12.93871 ? 182 ARG A NE  1 
ATOM   1478 C  CZ  . ARG A 1 182 ? -11.15297 11.61122  4.43064   1.000 20.73297 ? 182 ARG A CZ  1 
ATOM   1479 N  NH1 . ARG A 1 182 ? -11.31020 12.46152  5.42974   1.000 21.87921 ? 182 ARG A NH1 1 
ATOM   1480 N  NH2 . ARG A 1 182 ? -12.11574 10.72468  4.16305   1.000 21.33345 ? 182 ARG A NH2 1 
ATOM   1481 N  N   . GLY A 1 183 ? -3.66036  14.19292  2.99922   1.000 10.75390 ? 183 GLY A N   1 
ATOM   1482 C  CA  . GLY A 1 183 ? -2.77359  15.34077  2.91827   1.000 12.95652 ? 183 GLY A CA  1 
ATOM   1483 C  C   . GLY A 1 183 ? -1.48415  15.07132  2.18207   1.000 16.25791 ? 183 GLY A C   1 
ATOM   1484 O  O   . GLY A 1 183 ? -0.81235  16.01284  1.76054   1.000 14.70141 ? 183 GLY A O   1 
ATOM   1485 N  N   . LEU A 1 184 ? -1.11601  13.81093  2.03623   1.000 10.48732 ? 184 LEU A N   1 
ATOM   1486 C  CA  . LEU A 1 184 ? 0.12410   13.39711  1.38642   1.000 11.67714 ? 184 LEU A CA  1 
ATOM   1487 C  C   . LEU A 1 184 ? -0.21209  12.33659  0.35395   1.000 11.09461 ? 184 LEU A C   1 
ATOM   1488 O  O   . LEU A 1 184 ? -1.22542  11.64138  0.46510   1.000 13.05940 ? 184 LEU A O   1 
ATOM   1489 C  CB  . LEU A 1 184 ? 1.12221   12.75450  2.36172   1.000 18.25482 ? 184 LEU A CB  1 
ATOM   1490 C  CG  . LEU A 1 184 ? 1.50461   13.39147  3.68321   1.000 19.08660 ? 184 LEU A CG  1 
ATOM   1491 C  CD1 . LEU A 1 184 ? 2.49813   12.50941  4.43584   1.000 16.14519 ? 184 LEU A CD1 1 
ATOM   1492 C  CD2 . LEU A 1 184 ? 2.10264   14.75212  3.38568   1.000 26.21726 ? 184 LEU A CD2 1 
ATOM   1493 N  N   . ALA A 1 185 ? 0.65809   12.20252  -0.64150  1.000 8.00653  ? 185 ALA A N   1 
ATOM   1494 C  CA  . ALA A 1 185 ? 0.63405   11.08214  -1.57271  1.000 8.11291  ? 185 ALA A CA  1 
ATOM   1495 C  C   . ALA A 1 185 ? 1.89338   10.25444  -1.37235  1.000 6.59284  ? 185 ALA A C   1 
ATOM   1496 O  O   . ALA A 1 185 ? 2.85325   10.69858  -0.73016  1.000 8.89518  ? 185 ALA A O   1 
ATOM   1497 C  CB  . ALA A 1 185 ? 0.53815   11.55636  -3.03312  1.000 10.22476 ? 185 ALA A CB  1 
ATOM   1498 N  N   . HIS A 1 186 ? 1.88960   9.04113   -1.92182  1.000 7.22224  ? 186 HIS A N   1 
ATOM   1499 C  CA  . HIS A 1 186 ? 3.04493   8.18029   -1.69093  1.000 7.13454  ? 186 HIS A CA  1 
ATOM   1500 C  C   . HIS A 1 186 ? 3.30981   7.32916   -2.92362  1.000 6.36670  ? 186 HIS A C   1 
ATOM   1501 O  O   . HIS A 1 186 ? 2.42251   7.06232   -3.75921  1.000 6.92066  ? 186 HIS A O   1 
ATOM   1502 C  CB  . HIS A 1 186 ? 2.84998   7.27933   -0.44412  1.000 8.29165  ? 186 HIS A CB  1 
ATOM   1503 C  CG  . HIS A 1 186 ? 1.63880   6.40539   -0.49265  1.000 8.23740  ? 186 HIS A CG  1 
ATOM   1504 N  ND1 . HIS A 1 186 ? 0.37399   6.85497   -0.16590  1.000 10.76380 ? 186 HIS A ND1 1 
ATOM   1505 C  CD2 . HIS A 1 186 ? 1.50598   5.09897   -0.82191  1.000 10.10104 ? 186 HIS A CD2 1 
ATOM   1506 C  CE1 . HIS A 1 186 ? -0.49061  5.86334   -0.31083  1.000 11.27316 ? 186 HIS A CE1 1 
ATOM   1507 N  NE2 . HIS A 1 186 ? 0.17552   4.78475   -0.68193  1.000 10.90286 ? 186 HIS A NE2 1 
ATOM   1508 N  N   . ASP A 1 187 ? 4.56322   6.87988   -3.00951  1.000 6.73887  ? 187 ASP A N   1 
ATOM   1509 C  CA  . ASP A 1 187 ? 4.87251   5.76310   -3.88328  1.000 7.46010  ? 187 ASP A CA  1 
ATOM   1510 C  C   . ASP A 1 187 ? 6.03312   5.03422   -3.24563  1.000 9.06973  ? 187 ASP A C   1 
ATOM   1511 O  O   . ASP A 1 187 ? 6.54422   5.46079   -2.20998  1.000 7.62070  ? 187 ASP A O   1 
ATOM   1512 C  CB  . ASP A 1 187 ? 5.15221   6.19160   -5.33509  1.000 9.27922  ? 187 ASP A CB  1 
ATOM   1513 C  CG  . ASP A 1 187 ? 6.53760   6.79079   -5.56370  1.000 9.14160  ? 187 ASP A CG  1 
ATOM   1514 O  OD1 . ASP A 1 187 ? 7.15553   7.37833   -4.65584  1.000 10.24610 ? 187 ASP A OD1 1 
ATOM   1515 O  OD2 . ASP A 1 187 ? 6.98203   6.66617   -6.74077  1.000 13.30791 ? 187 ASP A OD2 1 
ATOM   1516 N  N   . VAL A 1 188 ? 6.39584   3.89219   -3.82740  1.000 6.98196  ? 188 VAL A N   1 
ATOM   1517 C  CA  . VAL A 1 188 ? 7.50211   3.07834   -3.31790  1.000 9.77017  ? 188 VAL A CA  1 
ATOM   1518 C  C   . VAL A 1 188 ? 8.31279   2.57647   -4.50749  1.000 11.61751 ? 188 VAL A C   1 
ATOM   1519 O  O   . VAL A 1 188 ? 7.75043   2.09579   -5.50075  1.000 11.33555 ? 188 VAL A O   1 
ATOM   1520 C  CB  . VAL A 1 188 ? 7.01096   1.89306   -2.45556  1.000 8.44210  ? 188 VAL A CB  1 
ATOM   1521 C  CG1 . VAL A 1 188 ? 8.17322   1.29772   -1.63954  1.000 10.96982 ? 188 VAL A CG1 1 
ATOM   1522 C  CG2 . VAL A 1 188 ? 5.91291   2.32822   -1.48352  1.000 10.26122 ? 188 VAL A CG2 1 
ATOM   1523 N  N   . THR A 1 189 ? 9.63966   2.67045   -4.41340  1.000 9.14746  ? 189 THR A N   1 
ATOM   1524 C  CA  . THR A 1 189 ? 10.44310  2.13382   -5.51673  1.000 8.90946  ? 189 THR A CA  1 
ATOM   1525 C  C   . THR A 1 189 ? 10.38948  0.59989   -5.54393  1.000 12.51508 ? 189 THR A C   1 
ATOM   1526 O  O   . THR A 1 189 ? 10.10974  -0.06025  -4.53859  1.000 11.95266 ? 189 THR A O   1 
ATOM   1527 C  CB  . THR A 1 189 ? 11.89153  2.62921   -5.43538  1.000 11.01357 ? 189 THR A CB  1 
ATOM   1528 O  OG1 . THR A 1 189 ? 12.55492  2.04633   -4.28210  1.000 12.18521 ? 189 THR A OG1 1 
ATOM   1529 C  CG2 . THR A 1 189 ? 11.96365  4.14711   -5.33291  1.000 12.73332 ? 189 THR A CG2 1 
ATOM   1530 N  N   . ASP A 1 190 ? 10.65227  0.02797   -6.71792  1.000 10.61134 ? 190 ASP A N   1 
ATOM   1531 C  CA  . ASP A 1 190 ? 10.56275  -1.41491  -6.91136  1.000 11.39901 ? 190 ASP A CA  1 
ATOM   1532 C  C   . ASP A 1 190 ? 11.47010  -2.16592  -5.93080  1.000 9.42821  ? 190 ASP A C   1 
ATOM   1533 O  O   . ASP A 1 190 ? 12.54179  -1.67472  -5.53880  1.000 12.58032 ? 190 ASP A O   1 
ATOM   1534 C  CB  . ASP A 1 190 ? 11.00293  -1.81537  -8.33476  1.000 12.23833 ? 190 ASP A CB  1 
ATOM   1535 C  CG  . ASP A 1 190 ? 10.06779  -1.33655  -9.41854  1.000 22.66210 ? 190 ASP A CG  1 
ATOM   1536 O  OD1 . ASP A 1 190 ? 8.99373   -0.78916  -9.10785  1.000 20.12564 ? 190 ASP A OD1 1 
ATOM   1537 O  OD2 . ASP A 1 190 ? 10.42634  -1.52147  -10.61036 1.000 24.20852 ? 190 ASP A OD2 1 
ATOM   1538 N  N   . VAL A 1 191 ? 11.01543  -3.36235  -5.55941  1.000 11.62863 ? 191 VAL A N   1 
ATOM   1539 C  CA  . VAL A 1 191 ? 11.83109  -4.33323  -4.82778  1.000 12.10464 ? 191 VAL A CA  1 
ATOM   1540 C  C   . VAL A 1 191 ? 12.84718  -4.89828  -5.80288  1.000 12.71708 ? 191 VAL A C   1 
ATOM   1541 O  O   . VAL A 1 191 ? 12.47765  -5.33756  -6.89265  1.000 12.89613 ? 191 VAL A O   1 
ATOM   1542 C  CB  . VAL A 1 191 ? 10.93965  -5.46144  -4.27218  1.000 11.47652 ? 191 VAL A CB  1 
ATOM   1543 C  CG1 . VAL A 1 191 ? 11.77518  -6.50213  -3.54141  1.000 15.63408 ? 191 VAL A CG1 1 
ATOM   1544 C  CG2 . VAL A 1 191 ? 9.87163   -4.92119  -3.36384  1.000 17.42235 ? 191 VAL A CG2 1 
ATOM   1545 N  N   . LEU A 1 192 ? 14.12364  -4.91352  -5.41615  1.000 11.54278 ? 192 LEU A N   1 
ATOM   1546 C  CA  . LEU A 1 192 ? 15.17138  -5.46396  -6.26114  1.000 14.09546 ? 192 LEU A CA  1 
ATOM   1547 C  C   . LEU A 1 192 ? 15.79080  -6.67945  -5.59489  1.000 13.71376 ? 192 LEU A C   1 
ATOM   1548 O  O   . LEU A 1 192 ? 15.87218  -6.75519  -4.36519  1.000 15.35393 ? 192 LEU A O   1 
ATOM   1549 C  CB  . LEU A 1 192 ? 16.27167  -4.44223  -6.48655  1.000 15.77968 ? 192 LEU A CB  1 
ATOM   1550 C  CG  . LEU A 1 192 ? 15.79737  -3.13227  -7.07972  1.000 18.60849 ? 192 LEU A CG  1 
ATOM   1551 C  CD1 . LEU A 1 192 ? 16.97558  -2.16464  -7.07386  1.000 24.88878 ? 192 LEU A CD1 1 
ATOM   1552 C  CD2 . LEU A 1 192 ? 15.25631  -3.35792  -8.46879  1.000 17.67121 ? 192 LEU A CD2 1 
ATOM   1553 N  N   . SER A 1 193 ? 16.25652  -7.61597  -6.41022  1.000 12.61091 ? 193 SER A N   1 
ATOM   1554 C  CA  . SER A 1 193 ? 17.06856  -8.70746  -5.88553  1.000 14.69241 ? 193 SER A CA  1 
ATOM   1555 C  C   . SER A 1 193 ? 18.38629  -8.16105  -5.34184  1.000 13.97601 ? 193 SER A C   1 
ATOM   1556 O  O   . SER A 1 193 ? 19.06455  -7.36116  -5.99767  1.000 15.97624 ? 193 SER A O   1 
ATOM   1557 C  CB  . SER A 1 193 ? 17.33899  -9.74030  -6.98453  1.000 13.90124 ? 193 SER A CB  1 
ATOM   1558 O  OG  . SER A 1 193 ? 18.32496  -10.67721 -6.52965  1.000 19.40398 ? 193 SER A OG  1 
ATOM   1559 N  N   . ALA A 1 194 ? 18.75502  -8.58386  -4.12135  1.000 15.71409 ? 194 ALA A N   1 
ATOM   1560 C  CA  . ALA A 1 194 ? 19.97575  -8.05213  -3.52623  1.000 19.99483 ? 194 ALA A CA  1 
ATOM   1561 C  C   . ALA A 1 194 ? 21.22966  -8.65461  -4.14948  1.000 19.57283 ? 194 ALA A C   1 
ATOM   1562 O  O   . ALA A 1 194 ? 22.28795  -8.00736  -4.15146  1.000 20.87420 ? 194 ALA A O   1 
ATOM   1563 C  CB  . ALA A 1 194 ? 19.97231  -8.27881  -2.01020  1.000 17.98864 ? 194 ALA A CB  1 
ATOM   1564 N  N   . ASP A 1 195 ? 21.13221  -9.86999  -4.69480  1.000 18.59976 ? 195 ASP A N   1 
ATOM   1565 C  CA  . ASP A 1 195 ? 22.32747  -10.54472 -5.18272  1.000 23.69853 ? 195 ASP A CA  1 
ATOM   1566 C  C   . ASP A 1 195 ? 22.15494  -11.21842 -6.53740  1.000 25.93245 ? 195 ASP A C   1 
ATOM   1567 O  O   . ASP A 1 195 ? 23.05219  -11.96490 -6.94853  1.000 28.24773 ? 195 ASP A O   1 
ATOM   1568 C  CB  . ASP A 1 195 ? 22.80367  -11.59072 -4.15630  1.000 23.73385 ? 195 ASP A CB  1 
ATOM   1569 C  CG  . ASP A 1 195 ? 21.88211  -12.80432 -4.06206  1.000 27.89320 ? 195 ASP A CG  1 
ATOM   1570 O  OD1 . ASP A 1 195 ? 20.82669  -12.84488 -4.73803  1.000 22.05371 ? 195 ASP A OD1 1 
ATOM   1571 O  OD2 . ASP A 1 195 ? 22.20797  -13.74232 -3.29017  1.000 32.52867 ? 195 ASP A OD2 1 
ATOM   1572 N  N   . GLY A 1 196 ? 21.03629  -11.01089 -7.23428  1.000 25.15385 ? 196 GLY A N   1 
ATOM   1573 C  CA  . GLY A 1 196 ? 20.76914  -11.67371 -8.48738  1.000 19.90235 ? 196 GLY A CA  1 
ATOM   1574 C  C   . GLY A 1 196 ? 19.82567  -12.85170 -8.38458  1.000 24.53773 ? 196 GLY A C   1 
ATOM   1575 O  O   . GLY A 1 196 ? 19.29363  -13.29358 -9.41719  1.000 22.76387 ? 196 GLY A O   1 
ATOM   1576 N  N   . GLY A 1 197 ? 19.59731  -13.36070 -7.17083  1.000 18.31062 ? 197 GLY A N   1 
ATOM   1577 C  CA  . GLY A 1 197 ? 18.70705  -14.46621 -6.94273  1.000 17.62336 ? 197 GLY A CA  1 
ATOM   1578 C  C   . GLY A 1 197 ? 17.35781  -14.01184 -6.39600  1.000 14.02169 ? 197 GLY A C   1 
ATOM   1579 O  O   . GLY A 1 197 ? 17.10254  -12.81762 -6.22264  1.000 18.66959 ? 197 GLY A O   1 
ATOM   1580 N  N   . PRO A 1 198 ? 16.47603  -14.96904 -6.12602  1.000 18.99298 ? 198 PRO A N   1 
ATOM   1581 C  CA  . PRO A 1 198 ? 15.13479  -14.61983 -5.63317  1.000 19.20565 ? 198 PRO A CA  1 
ATOM   1582 C  C   . PRO A 1 198 ? 15.17064  -13.97474 -4.25871  1.000 18.33545 ? 198 PRO A C   1 
ATOM   1583 O  O   . PRO A 1 198 ? 15.97265  -14.33550 -3.39127  1.000 18.91554 ? 198 PRO A O   1 
ATOM   1584 C  CB  . PRO A 1 198 ? 14.40833  -15.96508 -5.58336  1.000 19.61078 ? 198 PRO A CB  1 
ATOM   1585 C  CG  . PRO A 1 198 ? 15.48532  -17.02295 -5.72965  1.000 32.08609 ? 198 PRO A CG  1 
ATOM   1586 C  CD  . PRO A 1 198 ? 16.56494  -16.37865 -6.53530  1.000 21.73247 ? 198 PRO A CD  1 
ATOM   1587 N  N   . GLY A 1 199 ? 14.26179  -13.02131 -4.06071  1.000 13.09011 ? 199 GLY A N   1 
ATOM   1588 C  CA  . GLY A 1 199 ? 14.10154  -12.34114 -2.79220  1.000 14.23066 ? 199 GLY A CA  1 
ATOM   1589 C  C   . GLY A 1 199 ? 12.64066  -11.96592 -2.67835  1.000 15.12794 ? 199 GLY A C   1 
ATOM   1590 O  O   . GLY A 1 199 ? 11.87874  -12.06714 -3.64963  1.000 12.61466 ? 199 GLY A O   1 
ATOM   1591 N  N   . HIS A 1 200 ? 12.23652  -11.56456 -1.47407  1.000 11.06696 ? 200 HIS A N   1 
ATOM   1592 C  CA  . HIS A 1 200 ? 10.83899  -11.16709 -1.31655  1.000 12.50594 ? 200 HIS A CA  1 
ATOM   1593 C  C   . HIS A 1 200 ? 10.66669  -10.19136 -0.16247  1.000 11.02380 ? 200 HIS A C   1 
ATOM   1594 O  O   . HIS A 1 200 ? 11.50595  -10.07080 0.73227   1.000 10.27391 ? 200 HIS A O   1 
ATOM   1595 C  CB  . HIS A 1 200 ? 9.92799   -12.38523 -1.14761  1.000 13.86311 ? 200 HIS A CB  1 
ATOM   1596 C  CG  . HIS A 1 200 ? 10.17239  -13.16270 0.10114   1.000 16.85283 ? 200 HIS A CG  1 
ATOM   1597 N  ND1 . HIS A 1 200 ? 11.01874  -14.25070 0.14385   1.000 22.73076 ? 200 HIS A ND1 1 
ATOM   1598 C  CD2 . HIS A 1 200 ? 9.66991   -13.02111 1.34909   1.000 16.45668 ? 200 HIS A CD2 1 
ATOM   1599 C  CE1 . HIS A 1 200 ? 11.03848  -14.73490 1.37506   1.000 21.22152 ? 200 HIS A CE1 1 
ATOM   1600 N  NE2 . HIS A 1 200 ? 10.22169  -14.01673 2.12137   1.000 22.52439 ? 200 HIS A NE2 1 
ATOM   1601 N  N   . ARG A 1 201 ? 9.53897   -9.49258  -0.19583  1.000 8.62450  ? 201 ARG A N   1 
ATOM   1602 C  CA  . ARG A 1 201 ? 9.19745   -8.48953  0.79487   1.000 10.54076 ? 201 ARG A CA  1 
ATOM   1603 C  C   . ARG A 1 201 ? 7.75538   -8.73229  1.20578   1.000 10.97225 ? 201 ARG A C   1 
ATOM   1604 O  O   . ARG A 1 201 ? 6.84757   -8.68276  0.36472   1.000 7.56635  ? 201 ARG A O   1 
ATOM   1605 C  CB  . ARG A 1 201 ? 9.39744   -7.08868  0.21939   1.000 7.46732  ? 201 ARG A CB  1 
ATOM   1606 C  CG  . ARG A 1 201 ? 8.94540   -5.91447  1.11098   1.000 8.68054  ? 201 ARG A CG  1 
ATOM   1607 C  CD  . ARG A 1 201 ? 9.29840   -4.60427  0.38150   1.000 9.78687  ? 201 ARG A CD  1 
ATOM   1608 N  NE  . ARG A 1 201 ? 8.96040   -3.35598  1.06633   1.000 11.94176 ? 201 ARG A NE  1 
ATOM   1609 C  CZ  . ARG A 1 201 ? 7.84078   -2.67394  0.85987   1.000 9.54555  ? 201 ARG A CZ  1 
ATOM   1610 N  NH1 . ARG A 1 201 ? 6.80591   -3.21334  0.23121   1.000 8.73245  ? 201 ARG A NH1 1 
ATOM   1611 N  NH2 . ARG A 1 201 ? 7.75087   -1.41795  1.29721   1.000 10.41994 ? 201 ARG A NH2 1 
ATOM   1612 N  N   . ASP A 1 202 ? 7.55256   -8.99520  2.49762   1.000 7.25753  ? 202 ASP A N   1 
ATOM   1613 C  CA  . ASP A 1 202 ? 6.25694   -9.40170  3.03722   1.000 7.94102  ? 202 ASP A CA  1 
ATOM   1614 C  C   . ASP A 1 202 ? 5.71979   -8.26756  3.90000   1.000 9.20088  ? 202 ASP A C   1 
ATOM   1615 O  O   . ASP A 1 202 ? 6.38216   -7.84422  4.86199   1.000 8.27784  ? 202 ASP A O   1 
ATOM   1616 C  CB  . ASP A 1 202 ? 6.40588   -10.67424 3.88228   1.000 8.99888  ? 202 ASP A CB  1 
ATOM   1617 C  CG  . ASP A 1 202 ? 6.75260   -11.88764 3.06353   1.000 13.60474 ? 202 ASP A CG  1 
ATOM   1618 O  OD1 . ASP A 1 202 ? 6.53505   -11.87770 1.82628   1.000 13.37525 ? 202 ASP A OD1 1 
ATOM   1619 O  OD2 . ASP A 1 202 ? 7.21492   -12.89401 3.66598   1.000 13.90717 ? 202 ASP A OD2 1 
ATOM   1620 N  N   . ILE A 1 203 ? 4.50916   -7.77241  3.57730   1.000 6.52154  ? 203 ILE A N   1 
ATOM   1621 C  CA  . ILE A 1 203 ? 3.96751   -6.56930  4.21962   1.000 6.84656  ? 203 ILE A CA  1 
ATOM   1622 C  C   . ILE A 1 203 ? 2.48841   -6.77413  4.54261   1.000 6.75385  ? 203 ILE A C   1 
ATOM   1623 O  O   . ILE A 1 203 ? 1.83509   -7.73629  4.11302   1.000 6.94678  ? 203 ILE A O   1 
ATOM   1624 C  CB  . ILE A 1 203 ? 4.12676   -5.30474  3.34329   1.000 8.42728  ? 203 ILE A CB  1 
ATOM   1625 C  CG1 . ILE A 1 203 ? 3.24176   -5.39945  2.10054   1.000 7.21079  ? 203 ILE A CG1 1 
ATOM   1626 C  CG2 . ILE A 1 203 ? 5.58584   -5.08959  2.91813   1.000 8.04490  ? 203 ILE A CG2 1 
ATOM   1627 C  CD1 . ILE A 1 203 ? 3.27998   -4.09334  1.20886   1.000 8.22961  ? 203 ILE A CD1 1 
ATOM   1628 N  N   . VAL A 1 204 ? 1.95246   -5.84947  5.32011   1.000 6.20351  ? 204 VAL A N   1 
ATOM   1629 C  CA  . VAL A 1 204 ? 0.50562   -5.74822  5.46773   1.000 7.50950  ? 204 VAL A CA  1 
ATOM   1630 C  C   . VAL A 1 204 ? 0.16125   -4.27661  5.32388   1.000 7.83771  ? 204 VAL A C   1 
ATOM   1631 O  O   . VAL A 1 204 ? 0.86718   -3.40954  5.85659   1.000 8.83502  ? 204 VAL A O   1 
ATOM   1632 C  CB  . VAL A 1 204 ? -0.00010  -6.35099  6.79525   1.000 9.06664  ? 204 VAL A CB  1 
ATOM   1633 C  CG1 . VAL A 1 204 ? 0.61665   -5.66710  8.03123   1.000 11.89620 ? 204 VAL A CG1 1 
ATOM   1634 C  CG2 . VAL A 1 204 ? -1.52751  -6.31097  6.86636   1.000 10.06034 ? 204 VAL A CG2 1 
ATOM   1635 N  N   . ILE A 1 205 ? -0.87101  -3.98484  4.54090   1.000 6.23347  ? 205 ILE A N   1 
ATOM   1636 C  CA  . ILE A 1 205 ? -1.36492  -2.62343  4.34787   1.000 5.38254  ? 205 ILE A CA  1 
ATOM   1637 C  C   . ILE A 1 205 ? -2.74283  -2.52603  4.97349   1.000 6.25196  ? 205 ILE A C   1 
ATOM   1638 O  O   . ILE A 1 205 ? -3.59825  -3.38278  4.73224   1.000 7.60479  ? 205 ILE A O   1 
ATOM   1639 C  CB  . ILE A 1 205 ? -1.45316  -2.27448  2.85610   1.000 7.08915  ? 205 ILE A CB  1 
ATOM   1640 C  CG1 . ILE A 1 205 ? -0.08388  -2.48237  2.19649   1.000 8.69387  ? 205 ILE A CG1 1 
ATOM   1641 C  CG2 . ILE A 1 205 ? -1.92506  -0.83832  2.67430   1.000 8.31209  ? 205 ILE A CG2 1 
ATOM   1642 C  CD1 . ILE A 1 205 ? -0.20848  -2.60491  0.69974   1.000 18.08356 ? 205 ILE A CD1 1 
ATOM   1643 N  N   . ILE A 1 206 ? -2.95069  -1.51316  5.80153   1.000 5.19592  ? 206 ILE A N   1 
ATOM   1644 C  CA  . ILE A 1 206 ? -4.23964  -1.33384  6.44895   1.000 7.95555  ? 206 ILE A CA  1 
ATOM   1645 C  C   . ILE A 1 206 ? -4.74878  0.04751   6.07964   1.000 8.33278  ? 206 ILE A C   1 
ATOM   1646 O  O   . ILE A 1 206 ? -4.10301  1.06059   6.36986   1.000 9.39238  ? 206 ILE A O   1 
ATOM   1647 C  CB  . ILE A 1 206 ? -4.15670  -1.51888  7.96287   1.000 6.08212  ? 206 ILE A CB  1 
ATOM   1648 C  CG1 . ILE A 1 206 ? -3.54561  -2.88806  8.32264   1.000 8.33045  ? 206 ILE A CG1 1 
ATOM   1649 C  CG2 . ILE A 1 206 ? -5.57705  -1.38933  8.53859   1.000 10.13018 ? 206 ILE A CG2 1 
ATOM   1650 C  CD1 . ILE A 1 206 ? -2.07868  -2.79208  8.69653   1.000 10.97791 ? 206 ILE A CD1 1 
ATOM   1651 N  N   . ALA A 1 207 ? -5.91288  0.09385   5.46266   1.000 6.54944  ? 207 ALA A N   1 
ATOM   1652 C  CA  . ALA A 1 207 ? -6.50172  1.34712   5.02809   1.000 5.40359  ? 207 ALA A CA  1 
ATOM   1653 C  C   . ALA A 1 207 ? -7.69032  1.63878   5.93843   1.000 8.55858  ? 207 ALA A C   1 
ATOM   1654 O  O   . ALA A 1 207 ? -8.59419  0.79456   6.06731   1.000 9.05010  ? 207 ALA A O   1 
ATOM   1655 C  CB  . ALA A 1 207 ? -6.94997  1.27015   3.56021   1.000 10.23092 ? 207 ALA A CB  1 
ATOM   1656 N  N   . PHE A 1 208 ? -7.70974  2.84082   6.51812   1.000 6.01892  ? 208 PHE A N   1 
ATOM   1657 C  CA  . PHE A 1 208 ? -8.69504  3.23073   7.53541   1.000 8.29708  ? 208 PHE A CA  1 
ATOM   1658 C  C   . PHE A 1 208 ? -9.69824  4.22617   6.96659   1.000 8.06396  ? 208 PHE A C   1 
ATOM   1659 O  O   . PHE A 1 208 ? -9.31550  5.30479   6.47484   1.000 9.32858  ? 208 PHE A O   1 
ATOM   1660 C  CB  . PHE A 1 208 ? -8.05417  3.89557   8.76573   1.000 7.86951  ? 208 PHE A CB  1 
ATOM   1661 C  CG  . PHE A 1 208 ? -7.10294  3.02324   9.53620   1.000 11.28093 ? 208 PHE A CG  1 
ATOM   1662 C  CD1 . PHE A 1 208 ? -5.82221  2.77930   9.06936   1.000 8.89661  ? 208 PHE A CD1 1 
ATOM   1663 C  CD2 . PHE A 1 208 ? -7.47629  2.47470   10.75049  1.000 12.67223 ? 208 PHE A CD2 1 
ATOM   1664 C  CE1 . PHE A 1 208 ? -4.93517  1.97380   9.81226   1.000 11.74070 ? 208 PHE A CE1 1 
ATOM   1665 C  CE2 . PHE A 1 208 ? -6.60473  1.67670   11.48887  1.000 10.61323 ? 208 PHE A CE2 1 
ATOM   1666 C  CZ  . PHE A 1 208 ? -5.34184  1.42855   11.03574  1.000 8.84795  ? 208 PHE A CZ  1 
ATOM   1667 N  N   . SER A 1 209 ? -10.97104 3.91240   7.13362   1.000 7.84766  ? 209 SER A N   1 
ATOM   1668 C  CA  . SER A 1 209 ? -12.05328 4.83819   6.81913   1.000 8.10106  ? 209 SER A CA  1 
ATOM   1669 C  C   . SER A 1 209 ? -13.09339 4.81182   7.92528   1.000 10.69182 ? 209 SER A C   1 
ATOM   1670 O  O   . SER A 1 209 ? -13.33573 3.77391   8.55097   1.000 9.93754  ? 209 SER A O   1 
ATOM   1671 C  CB  . SER A 1 209 ? -12.72673 4.48347   5.50989   1.000 12.59147 ? 209 SER A CB  1 
ATOM   1672 O  OG  . SER A 1 209 ? -11.79052 4.63838   4.43397   1.000 13.43365 ? 209 SER A OG  1 
ATOM   1673 N  N   . ARG A 1 210 ? -13.73760 5.95826   8.13435   1.000 11.00726 ? 210 ARG A N   1 
ATOM   1674 C  CA  . ARG A 1 210 ? -14.86114 5.96158   9.07279   1.000 8.81239  ? 210 ARG A CA  1 
ATOM   1675 C  C   . ARG A 1 210 ? -15.96162 5.05182   8.53740   1.000 11.04836 ? 210 ARG A C   1 
ATOM   1676 O  O   . ARG A 1 210 ? -16.14408 4.89899   7.32221   1.000 10.59320 ? 210 ARG A O   1 
ATOM   1677 C  CB  . ARG A 1 210 ? -15.35121 7.39811   9.28220   1.000 9.47628  ? 210 ARG A CB  1 
ATOM   1678 C  CG  . ARG A 1 210 ? -14.33759 8.20194   10.06196  1.000 9.86234  ? 210 ARG A CG  1 
ATOM   1679 C  CD  . ARG A 1 210 ? -14.58295 9.70748   9.87409   1.000 12.17544 ? 210 ARG A CD  1 
ATOM   1680 N  NE  . ARG A 1 210 ? -13.38683 10.44733  10.26933  1.000 12.63247 ? 210 ARG A NE  1 
ATOM   1681 C  CZ  . ARG A 1 210 ? -13.10493 10.91424  11.48536  1.000 15.64427 ? 210 ARG A CZ  1 
ATOM   1682 N  NH1 . ARG A 1 210 ? -13.97970 10.85076  12.48726  1.000 18.07866 ? 210 ARG A NH1 1 
ATOM   1683 N  NH2 . ARG A 1 210 ? -11.91807 11.48504  11.70418  1.000 18.43269 ? 210 ARG A NH2 1 
ATOM   1684 N  N   . TRP A 1 211 ? -16.67911 4.38187   9.45939   1.000 10.46002 ? 211 TRP A N   1 
ATOM   1685 C  CA  . TRP A 1 211 ? -17.76023 3.51001   9.00401   1.000 9.79978  ? 211 TRP A CA  1 
ATOM   1686 C  C   . TRP A 1 211 ? -18.74888 4.26396   8.10403   1.000 11.31016 ? 211 TRP A C   1 
ATOM   1687 O  O   . TRP A 1 211 ? -19.25512 3.70368   7.13042   1.000 10.31272 ? 211 TRP A O   1 
ATOM   1688 C  CB  . TRP A 1 211 ? -18.49105 2.87949   10.21237  1.000 8.97940  ? 211 TRP A CB  1 
ATOM   1689 C  CG  . TRP A 1 211 ? -19.51759 1.87009   9.79244   1.000 11.95087 ? 211 TRP A CG  1 
ATOM   1690 C  CD1 . TRP A 1 211 ? -20.85407 2.07651   9.57260   1.000 12.52598 ? 211 TRP A CD1 1 
ATOM   1691 C  CD2 . TRP A 1 211 ? -19.25800 0.50748   9.46051   1.000 11.86598 ? 211 TRP A CD2 1 
ATOM   1692 N  NE1 . TRP A 1 211 ? -21.44547 0.90481   9.14088   1.000 13.12733 ? 211 TRP A NE1 1 
ATOM   1693 C  CE2 . TRP A 1 211 ? -20.48251 -0.07166  9.07147   1.000 14.38313 ? 211 TRP A CE2 1 
ATOM   1694 C  CE3 . TRP A 1 211 ? -18.09985 -0.28307  9.46413   1.000 13.39917 ? 211 TRP A CE3 1 
ATOM   1695 C  CZ2 . TRP A 1 211 ? -20.58227 -1.41567  8.68171   1.000 12.98919 ? 211 TRP A CZ2 1 
ATOM   1696 C  CZ3 . TRP A 1 211 ? -18.19799 -1.61924  9.08285   1.000 14.57034 ? 211 TRP A CZ3 1 
ATOM   1697 C  CH2 . TRP A 1 211 ? -19.42908 -2.15615  8.67022   1.000 13.93116 ? 211 TRP A CH2 1 
ATOM   1698 N  N   . ALA A 1 212 ? -18.99919 5.54749   8.38445   1.000 12.78421 ? 212 ALA A N   1 
ATOM   1699 C  CA  . ALA A 1 212 ? -19.88914 6.35775   7.55993   1.000 13.23317 ? 212 ALA A CA  1 
ATOM   1700 C  C   . ALA A 1 212 ? -19.38055 6.53259   6.13112   1.000 15.76190 ? 212 ALA A C   1 
ATOM   1701 O  O   . ALA A 1 212 ? -20.15405 6.91353   5.24792   1.000 15.11608 ? 212 ALA A O   1 
ATOM   1702 C  CB  . ALA A 1 212 ? -20.09137 7.72339   8.22208   1.000 13.61081 ? 212 ALA A CB  1 
ATOM   1703 N  N   . GLU A 1 213 ? -18.08921 6.28615   5.89582   1.000 12.43130 ? 213 GLU A N   1 
ATOM   1704 C  CA  . GLU A 1 213 ? -17.44070 6.37547   4.59035   1.000 16.24718 ? 213 GLU A CA  1 
ATOM   1705 C  C   . GLU A 1 213 ? -16.82783 5.04422   4.18146   1.000 14.13740 ? 213 GLU A C   1 
ATOM   1706 O  O   . GLU A 1 213 ? -15.80929 5.02163   3.47746   1.000 13.41310 ? 213 GLU A O   1 
ATOM   1707 C  CB  . GLU A 1 213 ? -16.34158 7.43175   4.63447   1.000 15.50641 ? 213 GLU A CB  1 
ATOM   1708 C  CG  . GLU A 1 213 ? -16.75049 8.73700   5.25734   1.000 23.52546 ? 213 GLU A CG  1 
ATOM   1709 C  CD  . GLU A 1 213 ? -15.67404 9.78399   5.11571   1.000 30.52729 ? 213 GLU A CD  1 
ATOM   1710 O  OE1 . GLU A 1 213 ? -14.63334 9.70737   5.79997   1.000 45.32726 ? 213 GLU A OE1 1 
ATOM   1711 O  OE2 . GLU A 1 213 ? -15.86341 10.67658  4.26755   1.000 61.17862 ? 213 GLU A OE2 1 
ATOM   1712 N  N   . LYS A 1 214 ? -17.40967 3.93046   4.62666   1.000 12.12493 ? 214 LYS A N   1 
ATOM   1713 C  CA  . LYS A 1 214 ? -16.72093 2.64639   4.53314   1.000 9.99117  ? 214 LYS A CA  1 
ATOM   1714 C  C   . LYS A 1 214 ? -16.53927 2.18841   3.08263   1.000 11.06749 ? 214 LYS A C   1 
ATOM   1715 O  O   . LYS A 1 214 ? -17.34196 2.47047   2.18601   1.000 11.65921 ? 214 LYS A O   1 
ATOM   1716 C  CB  . LYS A 1 214 ? -17.49887 1.55091   5.27838   1.000 11.17680 ? 214 LYS A CB  1 
ATOM   1717 C  CG  . LYS A 1 214 ? -18.91257 1.32618   4.76499   1.000 14.81050 ? 214 LYS A CG  1 
ATOM   1718 C  CD  . LYS A 1 214 ? -19.69603 0.45889   5.77319   1.000 14.56901 ? 214 LYS A CD  1 
ATOM   1719 C  CE  . LYS A 1 214 ? -20.98782 -0.07619  5.14804   1.000 18.09845 ? 214 LYS A CE  1 
ATOM   1720 N  NZ  . LYS A 1 214 ? -21.96189 0.95468   4.71243   1.000 19.43915 ? 214 LYS A NZ  1 
ATOM   1721 N  N   . TRP A 1 215 ? -15.48117 1.42349   2.87974   1.000 11.73772 ? 215 TRP A N   1 
ATOM   1722 C  CA  . TRP A 1 215 ? -15.18081 0.82022   1.58399   1.000 10.61636 ? 215 TRP A CA  1 
ATOM   1723 C  C   . TRP A 1 215 ? -15.67411 -0.61360  1.53638   1.000 11.66896 ? 215 TRP A C   1 
ATOM   1724 O  O   . TRP A 1 215 ? -14.93071 -1.56085  1.28476   1.000 11.36512 ? 215 TRP A O   1 
ATOM   1725 C  CB  . TRP A 1 215 ? -13.68050 0.90978   1.34674   1.000 9.15119  ? 215 TRP A CB  1 
ATOM   1726 C  CG  . TRP A 1 215 ? -13.19628 2.27393   0.97762   1.000 10.10881 ? 215 TRP A CG  1 
ATOM   1727 C  CD1 . TRP A 1 215 ? -13.39965 3.45821   1.63053   1.000 14.53542 ? 215 TRP A CD1 1 
ATOM   1728 C  CD2 . TRP A 1 215 ? -12.37816 2.56703   -0.15502  1.000 8.79131  ? 215 TRP A CD2 1 
ATOM   1729 N  NE1 . TRP A 1 215 ? -12.76202 4.49044   0.94035   1.000 14.32259 ? 215 TRP A NE1 1 
ATOM   1730 C  CE2 . TRP A 1 215 ? -12.13353 3.95294   -0.15769  1.000 11.83498 ? 215 TRP A CE2 1 
ATOM   1731 C  CE3 . TRP A 1 215 ? -11.85101 1.77856   -1.18512  1.000 13.26245 ? 215 TRP A CE3 1 
ATOM   1732 C  CZ2 . TRP A 1 215 ? -11.34723 4.57731   -1.15762  1.000 13.76398 ? 215 TRP A CZ2 1 
ATOM   1733 C  CZ3 . TRP A 1 215 ? -11.06911 2.40345   -2.17265  1.000 15.03397 ? 215 TRP A CZ3 1 
ATOM   1734 C  CH2 . TRP A 1 215 ? -10.83849 3.77231   -2.14524  1.000 12.23209 ? 215 TRP A CH2 1 
ATOM   1735 N  N   . TYR A 1 216 ? -16.94775 -0.80235  1.85062   1.000 9.62807  ? 216 TYR A N   1 
ATOM   1736 C  CA  . TYR A 1 216 ? -17.47502 -2.13991  2.08091   1.000 9.48707  ? 216 TYR A CA  1 
ATOM   1737 C  C   . TYR A 1 216 ? -18.96364 -2.12102  1.76675   1.000 11.31521 ? 216 TYR A C   1 
ATOM   1738 O  O   . TYR A 1 216 ? -19.67140 -1.22204  2.23458   1.000 13.57143 ? 216 TYR A O   1 
ATOM   1739 C  CB  . TYR A 1 216 ? -17.27811 -2.54266  3.54637   1.000 11.88302 ? 216 TYR A CB  1 
ATOM   1740 C  CG  . TYR A 1 216 ? -17.74845 -3.94264  3.82677   1.000 13.05883 ? 216 TYR A CG  1 
ATOM   1741 C  CD1 . TYR A 1 216 ? -16.93458 -5.01492  3.54919   1.000 10.68234 ? 216 TYR A CD1 1 
ATOM   1742 C  CD2 . TYR A 1 216 ? -19.01952 -4.18257  4.34855   1.000 12.95161 ? 216 TYR A CD2 1 
ATOM   1743 C  CE1 . TYR A 1 216 ? -17.34096 -6.31016  3.80154   1.000 11.13794 ? 216 TYR A CE1 1 
ATOM   1744 C  CE2 . TYR A 1 216 ? -19.45167 -5.47040  4.58914   1.000 15.70164 ? 216 TYR A CE2 1 
ATOM   1745 C  CZ  . TYR A 1 216 ? -18.61148 -6.53183  4.31435   1.000 14.51155 ? 216 TYR A CZ  1 
ATOM   1746 O  OH  . TYR A 1 216 ? -19.00872 -7.83996  4.54262   1.000 14.88567 ? 216 TYR A OH  1 
ATOM   1747 N  N   . GLY A 1 217 ? -19.43896 -3.09266  1.00588   1.000 11.61633 ? 217 GLY A N   1 
ATOM   1748 C  CA  . GLY A 1 217 ? -20.86632 -3.24042  0.79220   1.000 13.34951 ? 217 GLY A CA  1 
ATOM   1749 C  C   . GLY A 1 217 ? -21.32175 -2.80874  -0.59933  1.000 16.50180 ? 217 GLY A C   1 
ATOM   1750 O  O   . GLY A 1 217 ? -20.54188 -2.38598  -1.45161  1.000 13.35915 ? 217 GLY A O   1 
ATOM   1751 N  N   . ASP A 1 218 ? -22.64351 -2.91231  -0.80387  1.000 15.95419 ? 218 ASP A N   1 
ATOM   1752 C  CA  . ASP A 1 218 ? -23.21132 -2.77211  -2.14863  1.000 19.56292 ? 218 ASP A CA  1 
ATOM   1753 C  C   . ASP A 1 218 ? -23.02556 -1.37276  -2.71472  1.000 17.24328 ? 218 ASP A C   1 
ATOM   1754 O  O   . ASP A 1 218 ? -22.71764 -1.21737  -3.90349  1.000 15.51057 ? 218 ASP A O   1 
ATOM   1755 C  CB  . ASP A 1 218 ? -24.70760 -3.08865  -2.13025  1.000 23.95793 ? 218 ASP A CB  1 
ATOM   1756 C  CG  . ASP A 1 218 ? -24.99261 -4.54472  -1.97099  1.000 30.88569 ? 218 ASP A CG  1 
ATOM   1757 O  OD1 . ASP A 1 218 ? -24.12856 -5.36857  -2.34966  1.000 29.13123 ? 218 ASP A OD1 1 
ATOM   1758 O  OD2 . ASP A 1 218 ? -26.10047 -4.84934  -1.46499  1.000 36.14821 ? 218 ASP A OD2 1 
ATOM   1759 N  N   . GLU A 1 219 ? -23.27620 -0.34683  -1.89737  1.000 15.47969 ? 219 GLU A N   1 
ATOM   1760 C  CA  . GLU A 1 219 ? -23.17232 1.03427   -2.34753  1.000 18.41424 ? 219 GLU A CA  1 
ATOM   1761 C  C   . GLU A 1 219 ? -21.73940 1.37333   -2.72972  1.000 15.48239 ? 219 GLU A C   1 
ATOM   1762 O  O   . GLU A 1 219 ? -21.50185 1.99466   -3.77282  1.000 17.64657 ? 219 GLU A O   1 
ATOM   1763 C  CB  . GLU A 1 219 ? -23.66600 1.99095   -1.26023  1.000 22.16949 ? 219 GLU A CB  1 
ATOM   1764 C  CG  . GLU A 1 219 ? -23.51989 3.47256   -1.66861  1.000 26.58347 ? 219 GLU A CG  1 
ATOM   1765 C  CD  . GLU A 1 219 ? -23.96750 4.48229   -0.60684  1.000 36.00370 ? 219 GLU A CD  1 
ATOM   1766 O  OE1 . GLU A 1 219 ? -24.27605 4.07862   0.53609   1.000 37.39837 ? 219 GLU A OE1 1 
ATOM   1767 O  OE2 . GLU A 1 219 ? -23.99088 5.69642   -0.92737  1.000 40.19197 ? 219 GLU A OE2 1 
ATOM   1768 N  N   . HIS A 1 220 ? -20.77985 0.99277   -1.87471  1.000 16.32842 ? 220 HIS A N   1 
ATOM   1769 C  CA  . HIS A 1 220 ? -19.37462 1.19947   -2.19867  1.000 10.53585 ? 220 HIS A CA  1 
ATOM   1770 C  C   . HIS A 1 220 ? -19.02957 0.52849   -3.51478  1.000 13.03759 ? 220 HIS A C   1 
ATOM   1771 O  O   . HIS A 1 220 ? -18.39504 1.13559   -4.38472  1.000 12.47716 ? 220 HIS A O   1 
ATOM   1772 C  CB  . HIS A 1 220 ? -18.46222 0.65996   -1.09138  1.000 8.60837  ? 220 HIS A CB  1 
ATOM   1773 C  CG  . HIS A 1 220 ? -17.03454 0.52489   -1.54456  1.000 9.76279  ? 220 HIS A CG  1 
ATOM   1774 N  ND1 . HIS A 1 220 ? -16.21410 1.61640   -1.74492  1.000 11.07991 ? 220 HIS A ND1 1 
ATOM   1775 C  CD2 . HIS A 1 220 ? -16.33468 -0.55732  -1.96290  1.000 13.80157 ? 220 HIS A CD2 1 
ATOM   1776 C  CE1 . HIS A 1 220 ? -15.04953 1.20867   -2.22576  1.000 9.12165  ? 220 HIS A CE1 1 
ATOM   1777 N  NE2 . HIS A 1 220 ? -15.10468 -0.10370  -2.37862  1.000 9.85249  ? 220 HIS A NE2 1 
ATOM   1778 N  N   . ASP A 1 221 ? -19.39902 -0.74683  -3.65484  1.000 10.92376 ? 221 ASP A N   1 
ATOM   1779 C  CA  . ASP A 1 221 ? -19.04620 -1.48387  -4.86324  1.000 11.09819 ? 221 ASP A CA  1 
ATOM   1780 C  C   . ASP A 1 221 ? -19.60208 -0.80086  -6.10032  1.000 12.48063 ? 221 ASP A C   1 
ATOM   1781 O  O   . ASP A 1 221 ? -18.91794 -0.69447  -7.12146  1.000 13.86724 ? 221 ASP A O   1 
ATOM   1782 C  CB  . ASP A 1 221 ? -19.58687 -2.91099  -4.79824  1.000 12.92805 ? 221 ASP A CB  1 
ATOM   1783 C  CG  . ASP A 1 221 ? -18.82984 -3.80206  -3.84667  1.000 15.68559 ? 221 ASP A CG  1 
ATOM   1784 O  OD1 . ASP A 1 221 ? -17.78425 -3.39360  -3.28397  1.000 13.43715 ? 221 ASP A OD1 1 
ATOM   1785 O  OD2 . ASP A 1 221 ? -19.30037 -4.93812  -3.66834  1.000 16.82692 ? 221 ASP A OD2 1 
ATOM   1786 N  N   . ALA A 1 222 ? -20.85798 -0.33939  -6.02537  1.000 15.82199 ? 222 ALA A N   1 
ATOM   1787 C  CA  . ALA A 1 222 ? -21.48608 0.25537   -7.19582  1.000 16.12409 ? 222 ALA A CA  1 
ATOM   1788 C  C   . ALA A 1 222 ? -20.76294 1.52455   -7.59116  1.000 14.42930 ? 222 ALA A C   1 
ATOM   1789 O  O   . ALA A 1 222 ? -20.55495 1.79062   -8.78592  1.000 17.87121 ? 222 ALA A O   1 
ATOM   1790 C  CB  . ALA A 1 222 ? -22.96684 0.54103   -6.91583  1.000 18.70420 ? 222 ALA A CB  1 
ATOM   1791 N  N   . ALA A 1 223 ? -20.33643 2.30481   -6.59882  1.000 13.90690 ? 223 ALA A N   1 
ATOM   1792 C  CA  . ALA A 1 223 ? -19.60423 3.54064   -6.87573  1.000 15.75208 ? 223 ALA A CA  1 
ATOM   1793 C  C   . ALA A 1 223 ? -18.21924 3.24641   -7.45026  1.000 14.31930 ? 223 ALA A C   1 
ATOM   1794 O  O   . ALA A 1 223 ? -17.77679 3.90401   -8.40486  1.000 17.16888 ? 223 ALA A O   1 
ATOM   1795 C  CB  . ALA A 1 223 ? -19.49395 4.38420   -5.59929  1.000 16.07397 ? 223 ALA A CB  1 
ATOM   1796 N  N   . ALA A 1 224 ? -17.51349 2.27309   -6.87340  1.000 14.57477 ? 224 ALA A N   1 
ATOM   1797 C  CA  . ALA A 1 224 ? -16.15962 1.99527   -7.34832  1.000 12.98581 ? 224 ALA A CA  1 
ATOM   1798 C  C   . ALA A 1 224 ? -16.16686 1.39095   -8.74700  1.000 15.61976 ? 224 ALA A C   1 
ATOM   1799 O  O   . ALA A 1 224 ? -15.23937 1.64274   -9.52797  1.000 14.40516 ? 224 ALA A O   1 
ATOM   1800 C  CB  . ALA A 1 224 ? -15.44590 1.06961   -6.35710  1.000 11.00868 ? 224 ALA A CB  1 
ATOM   1801 N  N   . LEU A 1 225 ? -17.18664 0.59410   -9.07735  1.000 12.26289 ? 225 LEU A N   1 
ATOM   1802 C  CA  . LEU A 1 225 ? -17.33035 -0.06794  -10.37112 1.000 14.89598 ? 225 LEU A CA  1 
ATOM   1803 C  C   . LEU A 1 225 ? -18.00719 0.82865   -11.40472 1.000 20.09896 ? 225 LEU A C   1 
ATOM   1804 O  O   . LEU A 1 225 ? -18.09168 0.44881   -12.57896 1.000 22.81817 ? 225 LEU A O   1 
ATOM   1805 C  CB  . LEU A 1 225 ? -18.10857 -1.37082  -10.19201 1.000 14.91022 ? 225 LEU A CB  1 
ATOM   1806 C  CG  . LEU A 1 225 ? -17.44823 -2.44822  -9.31493  1.000 18.90901 ? 225 LEU A CG  1 
ATOM   1807 C  CD1 . LEU A 1 225 ? -18.36277 -3.63648  -9.11497  1.000 24.93576 ? 225 LEU A CD1 1 
ATOM   1808 C  CD2 . LEU A 1 225 ? -16.13504 -2.91357  -9.89336  1.000 19.38765 ? 225 LEU A CD2 1 
ATOM   1809 N  N   . GLU A 1 226 ? -18.46109 2.00755   -10.98091 1.000 19.56556 ? 226 GLU A N   1 
ATOM   1810 C  CA  . GLU A 1 226 ? -19.10835 3.01124   -11.82715 1.000 23.62230 ? 226 GLU A CA  1 
ATOM   1811 C  C   . GLU A 1 226 ? -20.39136 2.47006   -12.44893 1.000 35.60243 ? 226 GLU A C   1 
ATOM   1812 O  O   . GLU A 1 226 ? -20.77565 2.84596   -13.55873 1.000 46.07269 ? 226 GLU A O   1 
ATOM   1813 C  CB  . GLU A 1 226 ? -18.13887 3.53729   -12.88375 1.000 23.67258 ? 226 GLU A CB  1 
ATOM   1814 C  CG  . GLU A 1 226 ? -17.14882 4.51334   -12.27918 1.000 33.58422 ? 226 GLU A CG  1 
ATOM   1815 C  CD  . GLU A 1 226 ? -16.21429 5.12213   -13.30248 1.000 50.61667 ? 226 GLU A CD  1 
ATOM   1816 O  OE1 . GLU A 1 226 ? -15.44697 4.36850   -13.93965 1.000 49.76246 ? 226 GLU A OE1 1 
ATOM   1817 O  OE2 . GLU A 1 226 ? -16.24974 6.36052   -13.47612 1.000 55.43914 ? 226 GLU A OE2 1 
ATOM   1818 N  N   . GLU A 1 227 ? -21.07350 1.60068   -11.70619 1.000 34.09078 ? 227 GLU A N   1 
ATOM   1819 C  CA  . GLU A 1 227 ? -22.32232 0.99607   -12.15320 1.000 42.68788 ? 227 GLU A CA  1 
ATOM   1820 C  C   . GLU A 1 227 ? -23.50677 1.94698   -11.98257 1.000 52.77912 ? 227 GLU A C   1 
ATOM   1821 O  O   . GLU A 1 227 ? -23.94112 2.21881   -10.86233 1.000 53.01537 ? 227 GLU A O   1 
ATOM   1822 C  CB  . GLU A 1 227 ? -22.57370 -0.30526  -11.38618 1.000 36.89145 ? 227 GLU A CB  1 
ATOM   1823 C  CG  . GLU A 1 227 ? -21.63564 -1.44355  -11.78001 1.000 35.74924 ? 227 GLU A CG  1 
ATOM   1824 C  CD  . GLU A 1 227 ? -21.68952 -2.61148  -10.81465 1.000 43.96777 ? 227 GLU A CD  1 
ATOM   1825 O  OE1 . GLU A 1 227 ? -22.23776 -2.43279  -9.70197  1.000 44.91856 ? 227 GLU A OE1 1 
ATOM   1826 O  OE2 . GLU A 1 227 ? -21.18259 -3.70520  -11.16736 1.000 45.67497 ? 227 GLU A OE2 1 
ATOM   1827 N  N   . PRO B 1 2   ? 1.14274   13.04251  -46.27555 1.000 48.52925 ? 2   PRO B N   1 
ATOM   1828 C  CA  . PRO B 1 2   ? 1.41326   12.40354  -44.98404 1.000 36.38783 ? 2   PRO B CA  1 
ATOM   1829 C  C   . PRO B 1 2   ? 0.20484   12.43889  -44.04217 1.000 32.36521 ? 2   PRO B C   1 
ATOM   1830 O  O   . PRO B 1 2   ? -0.92650  12.35622  -44.51962 1.000 34.93307 ? 2   PRO B O   1 
ATOM   1831 C  CB  . PRO B 1 2   ? 2.56570   13.23829  -44.43350 1.000 46.21469 ? 2   PRO B CB  1 
ATOM   1832 C  CG  . PRO B 1 2   ? 2.29252   14.60741  -44.96655 1.000 51.14704 ? 2   PRO B CG  1 
ATOM   1833 C  CD  . PRO B 1 2   ? 1.73300   14.39221  -46.35327 1.000 49.68184 ? 2   PRO B CD  1 
ATOM   1834 N  N   . LEU B 1 3   ? 0.43620   12.57566  -42.73649 1.000 28.48210 ? 3   LEU B N   1 
ATOM   1835 C  CA  . LEU B 1 3   ? -0.65577  12.50982  -41.76933 1.000 24.89872 ? 3   LEU B CA  1 
ATOM   1836 C  C   . LEU B 1 3   ? -1.62609  13.67441  -41.93254 1.000 29.77524 ? 3   LEU B C   1 
ATOM   1837 O  O   . LEU B 1 3   ? -1.26132  14.75248  -42.40691 1.000 24.83389 ? 3   LEU B O   1 
ATOM   1838 C  CB  . LEU B 1 3   ? -0.09277  12.50884  -40.34092 1.000 19.68176 ? 3   LEU B CB  1 
ATOM   1839 C  CG  . LEU B 1 3   ? 0.61299   11.19426  -40.02619 1.000 18.74249 ? 3   LEU B CG  1 
ATOM   1840 C  CD1 . LEU B 1 3   ? 1.06535   11.14462  -38.57110 1.000 22.68668 ? 3   LEU B CD1 1 
ATOM   1841 C  CD2 . LEU B 1 3   ? -0.32629  10.02975  -40.33030 1.000 23.23087 ? 3   LEU B CD2 1 
ATOM   1842 N  N   . GLY B 1 4   ? -2.87932  13.44557  -41.53222 1.000 22.39637 ? 4   GLY B N   1 
ATOM   1843 C  CA  . GLY B 1 4   ? -3.83914  14.53196  -41.42944 1.000 21.86554 ? 4   GLY B CA  1 
ATOM   1844 C  C   . GLY B 1 4   ? -3.35543  15.73775  -40.63412 1.000 30.95726 ? 4   GLY B C   1 
ATOM   1845 O  O   . GLY B 1 4   ? -2.38405  15.62768  -39.88060 1.000 24.74083 ? 4   GLY B O   1 
ATOM   1846 N  N   . THR B 1 5   ? -4.01436  16.89517  -40.77693 1.000 23.94168 ? 5   THR B N   1 
ATOM   1847 C  CA  . THR B 1 5   ? -3.49566  18.10653  -40.15137 1.000 24.63594 ? 5   THR B CA  1 
ATOM   1848 C  C   . THR B 1 5   ? -3.52372  18.04137  -38.63779 1.000 28.96854 ? 5   THR B C   1 
ATOM   1849 O  O   . THR B 1 5   ? -2.79393  18.80157  -38.00875 1.000 32.27731 ? 5   THR B O   1 
ATOM   1850 C  CB  . THR B 1 5   ? -4.27517  19.32447  -40.67371 1.000 38.34726 ? 5   THR B CB  1 
ATOM   1851 O  OG1 . THR B 1 5   ? -5.60807  19.32052  -40.12853 1.000 45.84726 ? 5   THR B OG1 1 
ATOM   1852 C  CG2 . THR B 1 5   ? -4.37796  19.27007  -42.18027 1.000 25.56935 ? 5   THR B CG2 1 
ATOM   1853 N  N   . GLU B 1 6   ? -4.35435  17.18092  -38.05239 1.000 21.42630 ? 6   GLU B N   1 
ATOM   1854 C  CA  . GLU B 1 6   ? -4.44177  17.01805  -36.61553 1.000 23.61811 ? 6   GLU B CA  1 
ATOM   1855 C  C   . GLU B 1 6   ? -3.47134  15.97227  -36.08641 1.000 20.20105 ? 6   GLU B C   1 
ATOM   1856 O  O   . GLU B 1 6   ? -3.47501  15.69176  -34.87926 1.000 21.69852 ? 6   GLU B O   1 
ATOM   1857 C  CB  . GLU B 1 6   ? -5.86827  16.64007  -36.21344 1.000 25.43664 ? 6   GLU B CB  1 
ATOM   1858 C  CG  . GLU B 1 6   ? -6.88547  17.75380  -36.40728 1.000 36.34925 ? 6   GLU B CG  1 
ATOM   1859 C  CD  . GLU B 1 6   ? -8.07272  17.57422  -35.47676 1.000 52.62443 ? 6   GLU B CD  1 
ATOM   1860 O  OE1 . GLU B 1 6   ? -8.82659  16.59137  -35.66700 1.000 44.25497 ? 6   GLU B OE1 1 
ATOM   1861 O  OE2 . GLU B 1 6   ? -8.23300  18.39754  -34.54326 1.000 52.83331 ? 6   GLU B OE2 1 
ATOM   1862 N  N   . GLY B 1 7   ? -2.65481  15.39503  -36.95518 1.000 14.56692 ? 7   GLY B N   1 
ATOM   1863 C  CA  . GLY B 1 7   ? -1.58615  14.53483  -36.49503 1.000 16.60169 ? 7   GLY B CA  1 
ATOM   1864 C  C   . GLY B 1 7   ? -1.92033  13.06783  -36.49614 1.000 13.33309 ? 7   GLY B C   1 
ATOM   1865 O  O   . GLY B 1 7   ? -1.17789  12.28915  -35.88554 1.000 11.67620 ? 7   GLY B O   1 
ATOM   1866 N  N   . PHE B 1 8   ? -3.02285  12.68148  -37.13012 1.000 13.34149 ? 8   PHE B N   1 
ATOM   1867 C  CA  . PHE B 1 8   ? -3.37403  11.27292  -37.23921 1.000 11.14128 ? 8   PHE B CA  1 
ATOM   1868 C  C   . PHE B 1 8   ? -4.17429  11.05756  -38.51258 1.000 11.04332 ? 8   PHE B C   1 
ATOM   1869 O  O   . PHE B 1 8   ? -4.73498  11.99411  -39.08932 1.000 13.00484 ? 8   PHE B O   1 
ATOM   1870 C  CB  . PHE B 1 8   ? -4.17491  10.81243  -36.03093 1.000 10.56158 ? 8   PHE B CB  1 
ATOM   1871 C  CG  . PHE B 1 8   ? -5.58789  11.27546  -36.06655 1.000 10.92518 ? 8   PHE B CG  1 
ATOM   1872 C  CD1 . PHE B 1 8   ? -5.92396  12.57164  -35.69509 1.000 15.31918 ? 8   PHE B CD1 1 
ATOM   1873 C  CD2 . PHE B 1 8   ? -6.59593  10.42810  -36.48959 1.000 14.31916 ? 8   PHE B CD2 1 
ATOM   1874 C  CE1 . PHE B 1 8   ? -7.23702  12.98854  -35.70641 1.000 16.52113 ? 8   PHE B CE1 1 
ATOM   1875 C  CE2 . PHE B 1 8   ? -7.92818  10.83819  -36.51554 1.000 17.60334 ? 8   PHE B CE2 1 
ATOM   1876 C  CZ  . PHE B 1 8   ? -8.25346  12.13373  -36.14275 1.000 17.57553 ? 8   PHE B CZ  1 
ATOM   1877 N  N   . THR B 1 9   ? -4.20889  9.80573   -38.95879 1.000 9.61233  ? 9   THR B N   1 
ATOM   1878 C  CA  A THR B 1 9   ? -5.01948  9.36728   -40.08917 0.653 11.48038 ? 9   THR B CA  1 
ATOM   1879 C  CA  B THR B 1 9   ? -5.12954  9.41183   -40.00521 0.347 11.51159 ? 9   THR B CA  1 
ATOM   1880 C  C   . THR B 1 9   ? -5.57963  7.99042   -39.73893 1.000 12.59864 ? 9   THR B C   1 
ATOM   1881 O  O   . THR B 1 9   ? -4.83695  7.15844   -39.21558 1.000 13.84049 ? 9   THR B O   1 
ATOM   1882 C  CB  A THR B 1 9   ? -4.17573  9.30870   -41.40350 0.653 13.15463 ? 9   THR B CB  1 
ATOM   1883 C  CB  B THR B 1 9   ? -4.53326  9.48687   -41.40930 0.347 14.00384 ? 9   THR B CB  1 
ATOM   1884 O  OG1 A THR B 1 9   ? -3.72397  10.63739  -41.76573 0.653 14.18093 ? 9   THR B OG1 1 
ATOM   1885 O  OG1 B THR B 1 9   ? -5.55420  9.16902   -42.35979 0.347 14.90860 ? 9   THR B OG1 1 
ATOM   1886 C  CG2 A THR B 1 9   ? -4.96242  8.74674   -42.56876 0.653 17.65184 ? 9   THR B CG2 1 
ATOM   1887 C  CG2 B THR B 1 9   ? -3.40860  8.50383   -41.54375 0.347 13.34129 ? 9   THR B CG2 1 
ATOM   1888 N  N   . VAL B 1 10  ? -6.83867  7.73240   -40.06545 1.000 10.71759 ? 10  VAL B N   1 
ATOM   1889 C  CA  . VAL B 1 10  ? -7.39373  6.38661   -39.96391 1.000 7.84988  ? 10  VAL B CA  1 
ATOM   1890 C  C   . VAL B 1 10  ? -7.51910  5.84687   -41.37919 1.000 13.55742 ? 10  VAL B C   1 
ATOM   1891 O  O   . VAL B 1 10  ? -8.03024  6.53852   -42.26957 1.000 14.35916 ? 10  VAL B O   1 
ATOM   1892 C  CB  . VAL B 1 10  ? -8.74246  6.38722   -39.24611 1.000 9.54767  ? 10  VAL B CB  1 
ATOM   1893 C  CG1 . VAL B 1 10  ? -9.33955  4.96929   -39.23031 1.000 12.86190 ? 10  VAL B CG1 1 
ATOM   1894 C  CG2 . VAL B 1 10  ? -8.60166  6.93356   -37.79787 1.000 11.39795 ? 10  VAL B CG2 1 
ATOM   1895 N  N   . ILE B 1 11  ? -7.05025  4.62355   -41.58662 1.000 7.36862  ? 11  ILE B N   1 
ATOM   1896 C  CA  . ILE B 1 11  ? -7.08506  4.00274   -42.90618 1.000 11.26449 ? 11  ILE B CA  1 
ATOM   1897 C  C   . ILE B 1 11  ? -7.75849  2.64454   -42.84569 1.000 12.79907 ? 11  ILE B C   1 
ATOM   1898 O  O   . ILE B 1 11  ? -7.87016  2.02332   -41.79267 1.000 12.23383 ? 11  ILE B O   1 
ATOM   1899 C  CB  . ILE B 1 11  ? -5.68227  3.81986   -43.49235 1.000 11.93067 ? 11  ILE B CB  1 
ATOM   1900 C  CG1 . ILE B 1 11  ? -4.82569  2.89250   -42.58326 1.000 13.20746 ? 11  ILE B CG1 1 
ATOM   1901 C  CG2 . ILE B 1 11  ? -5.00405  5.18168   -43.67519 1.000 14.11889 ? 11  ILE B CG2 1 
ATOM   1902 C  CD1 . ILE B 1 11  ? -3.57478  2.38112   -43.29840 1.000 16.65947 ? 11  ILE B CD1 1 
ATOM   1903 N  N   . ASP B 1 12  ? -8.22457  2.19926   -44.01349 1.000 14.79687 ? 12  ASP B N   1 
ATOM   1904 C  CA  . ASP B 1 12  ? -8.65099  0.82113   -44.21879 1.000 14.29198 ? 12  ASP B CA  1 
ATOM   1905 C  C   . ASP B 1 12  ? -7.47549  -0.06969  -44.59285 1.000 17.65016 ? 12  ASP B C   1 
ATOM   1906 O  O   . ASP B 1 12  ? -6.55916  0.33860   -45.31604 1.000 19.58716 ? 12  ASP B O   1 
ATOM   1907 C  CB  . ASP B 1 12  ? -9.68601  0.74106   -45.33443 1.000 17.48505 ? 12  ASP B CB  1 
ATOM   1908 C  CG  . ASP B 1 12  ? -10.97564 1.38993   -44.97763 1.000 25.05876 ? 12  ASP B CG  1 
ATOM   1909 O  OD1 . ASP B 1 12  ? -11.33615 1.41664   -43.77069 1.000 25.41758 ? 12  ASP B OD1 1 
ATOM   1910 O  OD2 . ASP B 1 12  ? -11.63606 1.87143   -45.93665 1.000 36.24712 ? 12  ASP B OD2 1 
ATOM   1911 N  N   . LEU B 1 13  ? -7.50781  -1.24274  -44.11378 1.000 14.49926 ? 13  LEU B N   1 
ATOM   1912 C  CA  . LEU B 1 13  ? -6.45148  -2.18366  -44.41840 1.000 17.83675 ? 13  LEU B CA  1 
ATOM   1913 C  C   . LEU B 1 13  ? -6.84605  -3.12029  -45.55993 1.000 14.96718 ? 13  LEU B C   1 
ATOM   1914 O  O   . LEU B 1 13  ? -8.01676  -3.48173  -45.69657 1.000 19.47161 ? 13  LEU B O   1 
ATOM   1915 C  CB  . LEU B 1 13  ? -6.12430  -3.00936  -43.18295 1.000 17.78953 ? 13  LEU B CB  1 
ATOM   1916 C  CG  . LEU B 1 13  ? -5.52560  -2.17138  -42.06286 1.000 20.92033 ? 13  LEU B CG  1 
ATOM   1917 C  CD1 . LEU B 1 13  ? -5.31038  -3.06825  -40.86729 1.000 22.70632 ? 13  LEU B CD1 1 
ATOM   1918 C  CD2 . LEU B 1 13  ? -4.22264  -1.50332  -42.54455 1.000 20.71419 ? 13  LEU B CD2 1 
ATOM   1919 N  N   . PRO B 1 14  ? -5.84397  -3.52414  -46.33754 1.000 22.83869 ? 14  PRO B N   1 
ATOM   1920 C  CA  . PRO B 1 14  ? -6.05753  -4.55349  -47.35023 1.000 29.77188 ? 14  PRO B CA  1 
ATOM   1921 C  C   . PRO B 1 14  ? -6.33869  -5.89393  -46.69455 1.000 28.21479 ? 14  PRO B C   1 
ATOM   1922 O  O   . PRO B 1 14  ? -6.10757  -6.10352  -45.50438 1.000 19.51441 ? 14  PRO B O   1 
ATOM   1923 C  CB  . PRO B 1 14  ? -4.72749  -4.57565  -48.09924 1.000 31.09540 ? 14  PRO B CB  1 
ATOM   1924 C  CG  . PRO B 1 14  ? -3.72609  -4.21222  -47.06409 1.000 32.45677 ? 14  PRO B CG  1 
ATOM   1925 C  CD  . PRO B 1 14  ? -4.41738  -3.19168  -46.19753 1.000 24.24545 ? 14  PRO B CD  1 
ATOM   1926 N  N   . GLU B 1 15  ? -6.88008  -6.80018  -47.50147 1.000 27.00281 ? 15  GLU B N   1 
ATOM   1927 C  CA  . GLU B 1 15  ? -6.99036  -8.19738  -47.10615 1.000 28.65469 ? 15  GLU B CA  1 
ATOM   1928 C  C   . GLU B 1 15  ? -5.63357  -8.71937  -46.66805 1.000 18.57764 ? 15  GLU B C   1 
ATOM   1929 O  O   . GLU B 1 15  ? -4.60296  -8.41988  -47.28352 1.000 21.21081 ? 15  GLU B O   1 
ATOM   1930 C  CB  . GLU B 1 15  ? -7.50445  -9.03034  -48.28203 1.000 35.13132 ? 15  GLU B CB  1 
ATOM   1931 C  CG  . GLU B 1 15  ? -8.64764  -9.96174  -47.94718 1.000 48.70717 ? 15  GLU B CG  1 
ATOM   1932 C  CD  . GLU B 1 15  ? -9.21269  -10.63385 -49.18468 1.000 60.60345 ? 15  GLU B CD  1 
ATOM   1933 O  OE1 . GLU B 1 15  ? -8.57432  -10.53430 -50.25556 1.000 57.73353 ? 15  GLU B OE1 1 
ATOM   1934 O  OE2 . GLU B 1 15  ? -10.29437 -11.25329 -49.09020 1.000 56.44411 ? 15  GLU B OE2 1 
ATOM   1935 N  N   . VAL B 1 16  ? -5.63148  -9.55944  -45.63252 1.000 22.06614 ? 16  VAL B N   1 
ATOM   1936 C  CA  . VAL B 1 16  ? -4.37303  -10.09107 -45.12759 1.000 18.06054 ? 16  VAL B CA  1 
ATOM   1937 C  C   . VAL B 1 16  ? -4.28672  -11.56663 -45.50371 1.000 15.39641 ? 16  VAL B C   1 
ATOM   1938 O  O   . VAL B 1 16  ? -5.28126  -12.20688 -45.86295 1.000 19.98665 ? 16  VAL B O   1 
ATOM   1939 C  CB  . VAL B 1 16  ? -4.21036  -9.90065  -43.60480 1.000 22.17032 ? 16  VAL B CB  1 
ATOM   1940 C  CG1 . VAL B 1 16  ? -4.31630  -8.40515  -43.22419 1.000 26.14253 ? 16  VAL B CG1 1 
ATOM   1941 C  CG2 . VAL B 1 16  ? -5.23260  -10.70570 -42.85327 1.000 19.17763 ? 16  VAL B CG2 1 
ATOM   1942 N  N   . ALA B 1 17  ? -3.06983  -12.08257 -45.44869 1.000 14.05019 ? 17  ALA B N   1 
ATOM   1943 C  CA  . ALA B 1 17  ? -2.80716  -13.46907 -45.81762 1.000 16.50826 ? 17  ALA B CA  1 
ATOM   1944 C  C   . ALA B 1 17  ? -3.47267  -14.41791 -44.81653 1.000 18.02092 ? 17  ALA B C   1 
ATOM   1945 O  O   . ALA B 1 17  ? -3.66340  -14.07115 -43.64466 1.000 13.87260 ? 17  ALA B O   1 
ATOM   1946 C  CB  . ALA B 1 17  ? -1.30259  -13.70968 -45.86287 1.000 17.22895 ? 17  ALA B CB  1 
ATOM   1947 N  N   . PRO B 1 18  ? -3.83326  -15.63435 -45.24855 1.000 14.48006 ? 18  PRO B N   1 
ATOM   1948 C  CA  . PRO B 1 18  ? -4.60410  -16.54334 -44.38076 1.000 16.12233 ? 18  PRO B CA  1 
ATOM   1949 C  C   . PRO B 1 18  ? -3.87812  -17.03594 -43.13766 1.000 12.22310 ? 18  PRO B C   1 
ATOM   1950 O  O   . PRO B 1 18  ? -4.55760  -17.58253 -42.25393 1.000 12.85041 ? 18  PRO B O   1 
ATOM   1951 C  CB  . PRO B 1 18  ? -4.94479  -17.72769 -45.30273 1.000 19.29546 ? 18  PRO B CB  1 
ATOM   1952 C  CG  . PRO B 1 18  ? -4.20029  -17.51690 -46.55366 1.000 18.49672 ? 18  PRO B CG  1 
ATOM   1953 C  CD  . PRO B 1 18  ? -3.78333  -16.08978 -46.64888 1.000 17.23170 ? 18  PRO B CD  1 
ATOM   1954 N  N   . ASP B 1 19  ? -2.55859  -16.84761 -43.02422 1.000 12.92319 ? 19  ASP B N   1 
ATOM   1955 C  CA  . ASP B 1 19  ? -1.91860  -17.25157 -41.78548 1.000 14.43903 ? 19  ASP B CA  1 
ATOM   1956 C  C   . ASP B 1 19  ? -1.95815  -16.19105 -40.68643 1.000 12.22445 ? 19  ASP B C   1 
ATOM   1957 O  O   . ASP B 1 19  ? -1.63384  -16.52513 -39.54158 1.000 11.92160 ? 19  ASP B O   1 
ATOM   1958 C  CB  . ASP B 1 19  ? -0.46608  -17.69339 -42.02105 1.000 14.08760 ? 19  ASP B CB  1 
ATOM   1959 C  CG  . ASP B 1 19  ? 0.40541   -16.61143 -42.57864 1.000 17.94941 ? 19  ASP B CG  1 
ATOM   1960 O  OD1 . ASP B 1 19  ? -0.09565  -15.50308 -42.86437 1.000 25.42040 ? 19  ASP B OD1 1 
ATOM   1961 O  OD2 . ASP B 1 19  ? 1.62024   -16.88562 -42.73222 1.000 26.32951 ? 19  ASP B OD2 1 
ATOM   1962 N  N   . ILE B 1 20  ? -2.41950  -14.96267 -40.95976 1.000 10.57217 ? 20  ILE B N   1 
ATOM   1963 C  CA  . ILE B 1 20  ? -2.27169  -13.89359 -39.96120 1.000 9.75064  ? 20  ILE B CA  1 
ATOM   1964 C  C   . ILE B 1 20  ? -3.23657  -14.08259 -38.78633 1.000 7.53106  ? 20  ILE B C   1 
ATOM   1965 O  O   . ILE B 1 20  ? -2.82909  -14.14594 -37.61466 1.000 9.70177  ? 20  ILE B O   1 
ATOM   1966 C  CB  . ILE B 1 20  ? -2.48167  -12.51571 -40.61186 1.000 11.98808 ? 20  ILE B CB  1 
ATOM   1967 C  CG1 . ILE B 1 20  ? -1.47426  -12.27861 -41.72956 1.000 16.00962 ? 20  ILE B CG1 1 
ATOM   1968 C  CG2 . ILE B 1 20  ? -2.33691  -11.41354 -39.54437 1.000 12.87785 ? 20  ILE B CG2 1 
ATOM   1969 C  CD1 . ILE B 1 20  ? -0.05170  -12.22944 -41.26214 1.000 21.59975 ? 20  ILE B CD1 1 
ATOM   1970 N  N   . LEU B 1 21  ? -4.53318  -14.18514 -39.06454 1.000 10.15462 ? 21  LEU B N   1 
ATOM   1971 C  CA  . LEU B 1 21  ? -5.48819  -14.25958 -37.96528 1.000 10.60001 ? 21  LEU B CA  1 
ATOM   1972 C  C   . LEU B 1 21  ? -5.28624  -15.50210 -37.11353 1.000 10.96256 ? 21  LEU B C   1 
ATOM   1973 O  O   . LEU B 1 21  ? -5.30811  -15.38883 -35.87191 1.000 10.07031 ? 21  LEU B O   1 
ATOM   1974 C  CB  . LEU B 1 21  ? -6.92997  -14.14453 -38.48941 1.000 10.00776 ? 21  LEU B CB  1 
ATOM   1975 C  CG  . LEU B 1 21  ? -7.53063  -12.73035 -38.48421 1.000 16.30973 ? 21  LEU B CG  1 
ATOM   1976 C  CD1 . LEU B 1 21  ? -6.67189  -11.74475 -39.21207 1.000 17.97749 ? 21  LEU B CD1 1 
ATOM   1977 C  CD2 . LEU B 1 21  ? -8.92332  -12.75064 -39.03275 1.000 16.27897 ? 21  LEU B CD2 1 
ATOM   1978 N  N   . PRO B 1 22  ? -5.02506  -16.67689 -37.67305 1.000 9.40937  ? 22  PRO B N   1 
ATOM   1979 C  CA  . PRO B 1 22  ? -4.81066  -17.84046 -36.81716 1.000 9.73698  ? 22  PRO B CA  1 
ATOM   1980 C  C   . PRO B 1 22  ? -3.59993  -17.73688 -35.92085 1.000 8.68503  ? 22  PRO B C   1 
ATOM   1981 O  O   . PRO B 1 22  ? -3.57926  -18.36176 -34.84503 1.000 10.88706 ? 22  PRO B O   1 
ATOM   1982 C  CB  . PRO B 1 22  ? -4.62897  -18.98311 -37.83431 1.000 11.71007 ? 22  PRO B CB  1 
ATOM   1983 C  CG  . PRO B 1 22  ? -5.38756  -18.56536 -38.98817 1.000 12.64386 ? 22  PRO B CG  1 
ATOM   1984 C  CD  . PRO B 1 22  ? -5.19435  -17.05833 -39.09066 1.000 12.31773 ? 22  PRO B CD  1 
ATOM   1985 N  N   . SER B 1 23  ? -2.59048  -16.96118 -36.32549 1.000 8.95729  ? 23  SER B N   1 
ATOM   1986 C  CA  . SER B 1 23  ? -1.35368  -16.89994 -35.56229 1.000 7.80609  ? 23  SER B CA  1 
ATOM   1987 C  C   . SER B 1 23  ? -1.58103  -16.31161 -34.18002 1.000 7.87095  ? 23  SER B C   1 
ATOM   1988 O  O   . SER B 1 23  ? -0.73579  -16.49572 -33.29769 1.000 8.92210  ? 23  SER B O   1 
ATOM   1989 C  CB  . SER B 1 23  ? -0.29256  -16.10657 -36.31423 1.000 10.03879 ? 23  SER B CB  1 
ATOM   1990 O  OG  . SER B 1 23  ? -0.60453  -14.71396 -36.39077 1.000 9.10011  ? 23  SER B OG  1 
ATOM   1991 N  N   . TYR B 1 24  ? -2.68209  -15.58875 -33.98664 1.000 8.49772  ? 24  TYR B N   1 
ATOM   1992 C  CA  . TYR B 1 24  ? -2.89182  -14.99336 -32.67615 1.000 7.54297  ? 24  TYR B CA  1 
ATOM   1993 C  C   . TYR B 1 24  ? -3.17234  -16.05367 -31.63132 1.000 7.41848  ? 24  TYR B C   1 
ATOM   1994 O  O   . TYR B 1 24  ? -2.92079  -15.82569 -30.43947 1.000 9.49506  ? 24  TYR B O   1 
ATOM   1995 C  CB  . TYR B 1 24  ? -4.02509  -13.95382 -32.71247 1.000 7.98917  ? 24  TYR B CB  1 
ATOM   1996 C  CG  . TYR B 1 24  ? -3.58002  -12.63816 -33.31222 1.000 6.61482  ? 24  TYR B CG  1 
ATOM   1997 C  CD1 . TYR B 1 24  ? -3.62500  -12.41504 -34.70987 1.000 6.23018  ? 24  TYR B CD1 1 
ATOM   1998 C  CD2 . TYR B 1 24  ? -3.05470  -11.63510 -32.50839 1.000 7.01614  ? 24  TYR B CD2 1 
ATOM   1999 C  CE1 . TYR B 1 24  ? -3.15446  -11.20882 -35.27409 1.000 7.65193  ? 24  TYR B CE1 1 
ATOM   2000 C  CE2 . TYR B 1 24  ? -2.62276  -10.41819 -33.05617 1.000 6.74330  ? 24  TYR B CE2 1 
ATOM   2001 C  CZ  . TYR B 1 24  ? -2.64056  -10.22556 -34.41163 1.000 7.82152  ? 24  TYR B CZ  1 
ATOM   2002 O  OH  . TYR B 1 24  ? -2.21247  -9.04170  -34.95686 1.000 9.09272  ? 24  TYR B OH  1 
ATOM   2003 N  N   . ASP B 1 25  ? -3.69328  -17.20896 -32.05610 1.000 9.93163  ? 25  ASP B N   1 
ATOM   2004 C  CA  . ASP B 1 25  ? -3.95125  -18.26672 -31.09831 1.000 9.40977  ? 25  ASP B CA  1 
ATOM   2005 C  C   . ASP B 1 25  ? -2.66933  -18.87102 -30.57299 1.000 13.20076 ? 25  ASP B C   1 
ATOM   2006 O  O   . ASP B 1 25  ? -2.72336  -19.62748 -29.59553 1.000 15.54971 ? 25  ASP B O   1 
ATOM   2007 C  CB  . ASP B 1 25  ? -4.80579  -19.35644 -31.75626 1.000 13.40763 ? 25  ASP B CB  1 
ATOM   2008 C  CG  . ASP B 1 25  ? -6.20635  -18.88324 -32.10912 1.000 21.76431 ? 25  ASP B CG  1 
ATOM   2009 O  OD1 . ASP B 1 25  ? -6.81989  -18.15439 -31.30246 1.000 20.43525 ? 25  ASP B OD1 1 
ATOM   2010 O  OD2 . ASP B 1 25  ? -6.72349  -19.26393 -33.19372 1.000 29.07502 ? 25  ASP B OD2 1 
ATOM   2011 N  N   . ARG B 1 26  ? -1.52928  -18.56358 -31.19447 1.000 10.08452 ? 26  ARG B N   1 
ATOM   2012 C  CA  . ARG B 1 26  ? -0.25129  -19.13125 -30.78633 1.000 8.34978  ? 26  ARG B CA  1 
ATOM   2013 C  C   . ARG B 1 26  ? 0.65561   -18.09558 -30.13301 1.000 10.50259 ? 26  ARG B C   1 
ATOM   2014 O  O   . ARG B 1 26  ? 1.86628   -18.30598 -30.05649 1.000 12.31244 ? 26  ARG B O   1 
ATOM   2015 C  CB  . ARG B 1 26  ? 0.44495   -19.78212 -31.98159 1.000 13.36696 ? 26  ARG B CB  1 
ATOM   2016 C  CG  . ARG B 1 26  ? -0.40517  -20.84782 -32.59642 1.000 17.08641 ? 26  ARG B CG  1 
ATOM   2017 C  CD  . ARG B 1 26  ? 0.35547   -21.61020 -33.64987 1.000 15.49533 ? 26  ARG B CD  1 
ATOM   2018 N  NE  . ARG B 1 26  ? 0.88542   -20.75072 -34.70595 1.000 17.96258 ? 26  ARG B NE  1 
ATOM   2019 C  CZ  . ARG B 1 26  ? 0.21339   -20.39271 -35.79649 1.000 19.67825 ? 26  ARG B CZ  1 
ATOM   2020 N  NH1 . ARG B 1 26  ? -1.04230  -20.76179 -35.98980 1.000 21.34890 ? 26  ARG B NH1 1 
ATOM   2021 N  NH2 . ARG B 1 26  ? 0.80951   -19.61770 -36.69038 1.000 23.44167 ? 26  ARG B NH2 1 
ATOM   2022 N  N   . CYS B 1 27  ? 0.10129   -16.94179 -29.72235 1.000 11.26657 ? 27  CYS B N   1 
ATOM   2023 C  CA  . CYS B 1 27  ? 0.88368   -15.95819 -28.95990 1.000 11.47073 ? 27  CYS B CA  1 
ATOM   2024 C  C   . CYS B 1 27  ? 0.86509   -16.31642 -27.47790 1.000 8.06290  ? 27  CYS B C   1 
ATOM   2025 O  O   . CYS B 1 27  ? -0.21500  -16.46062 -26.89920 1.000 10.65608 ? 27  CYS B O   1 
ATOM   2026 C  CB  . CYS B 1 27  ? 0.33114   -14.55700 -29.18352 1.000 7.99132  ? 27  CYS B CB  1 
ATOM   2027 S  SG  . CYS B 1 27  ? 0.67216   -13.94300 -30.90314 1.000 11.73958 ? 27  CYS B SG  1 
ATOM   2028 N  N   . PRO B 1 28  ? 2.02188   -16.47399 -26.83510 1.000 9.38041  ? 28  PRO B N   1 
ATOM   2029 C  CA  . PRO B 1 28  ? 2.04151   -16.83035 -25.41015 1.000 8.07108  ? 28  PRO B CA  1 
ATOM   2030 C  C   . PRO B 1 28  ? 1.71890   -15.62845 -24.54491 1.000 9.20646  ? 28  PRO B C   1 
ATOM   2031 O  O   . PRO B 1 28  ? 1.77265   -14.48000 -24.99284 1.000 9.77542  ? 28  PRO B O   1 
ATOM   2032 C  CB  . PRO B 1 28  ? 3.47314   -17.29423 -25.16708 1.000 14.20844 ? 28  PRO B CB  1 
ATOM   2033 C  CG  . PRO B 1 28  ? 4.27157   -16.61930 -26.20583 1.000 16.03540 ? 28  PRO B CG  1 
ATOM   2034 C  CD  . PRO B 1 28  ? 3.36939   -16.36394 -27.40480 1.000 11.28439 ? 28  PRO B CD  1 
ATOM   2035 N  N   . VAL B 1 29  ? 1.39941   -15.91182 -23.28399 1.000 11.06856 ? 29  VAL B N   1 
ATOM   2036 C  CA  . VAL B 1 29  ? 1.01334   -14.83228 -22.37189 1.000 10.91625 ? 29  VAL B CA  1 
ATOM   2037 C  C   . VAL B 1 29  ? 2.15502   -13.84376 -22.19402 1.000 11.24843 ? 29  VAL B C   1 
ATOM   2038 O  O   . VAL B 1 29  ? 3.34710   -14.19498 -22.19376 1.000 10.93679 ? 29  VAL B O   1 
ATOM   2039 C  CB  . VAL B 1 29  ? 0.52225   -15.37163 -21.02094 1.000 11.64726 ? 29  VAL B CB  1 
ATOM   2040 C  CG1 . VAL B 1 29  ? 1.65545   -16.01493 -20.22414 1.000 20.58613 ? 29  VAL B CG1 1 
ATOM   2041 C  CG2 . VAL B 1 29  ? -0.15132  -14.25758 -20.19143 1.000 11.82526 ? 29  VAL B CG2 1 
ATOM   2042 N  N   . ASP B 1 30  ? 1.78263   -12.56572 -22.09872 1.000 7.80086  ? 30  ASP B N   1 
ATOM   2043 C  CA  . ASP B 1 30  ? 2.70281   -11.47037 -21.80241 1.000 8.62141  ? 30  ASP B CA  1 
ATOM   2044 C  C   . ASP B 1 30  ? 2.94698   -11.48296 -20.30425 1.000 8.16793  ? 30  ASP B C   1 
ATOM   2045 O  O   . ASP B 1 30  ? 2.03005   -11.21400 -19.52496 1.000 9.59894  ? 30  ASP B O   1 
ATOM   2046 C  CB  . ASP B 1 30  ? 2.09361   -10.13783 -22.25412 1.000 9.44605  ? 30  ASP B CB  1 
ATOM   2047 C  CG  . ASP B 1 30  ? 3.04661   -8.95710  -22.11667 1.000 10.44049 ? 30  ASP B CG  1 
ATOM   2048 O  OD1 . ASP B 1 30  ? 4.05004   -9.01617  -21.35450 1.000 10.12408 ? 30  ASP B OD1 1 
ATOM   2049 O  OD2 . ASP B 1 30  ? 2.79970   -7.94573  -22.80008 1.000 12.72950 ? 30  ASP B OD2 1 
ATOM   2050 N  N   . ASP B 1 31  ? 4.15640   -11.86767 -19.88247 1.000 8.10930  ? 31  ASP B N   1 
ATOM   2051 C  CA  . ASP B 1 31  ? 4.39489   -11.99379 -18.44838 1.000 9.08239  ? 31  ASP B CA  1 
ATOM   2052 C  C   . ASP B 1 31  ? 4.58451   -10.65034 -17.75889 1.000 9.51705  ? 31  ASP B C   1 
ATOM   2053 O  O   . ASP B 1 31  ? 4.64448   -10.61147 -16.51577 1.000 10.77241 ? 31  ASP B O   1 
ATOM   2054 C  CB  . ASP B 1 31  ? 5.66474   -12.83218 -18.18742 1.000 13.47870 ? 31  ASP B CB  1 
ATOM   2055 C  CG  . ASP B 1 31  ? 5.48999   -14.30941 -18.52418 1.000 23.12787 ? 31  ASP B CG  1 
ATOM   2056 O  OD1 . ASP B 1 31  ? 4.38237   -14.86339 -18.31926 1.000 23.02659 ? 31  ASP B OD1 1 
ATOM   2057 O  OD2 . ASP B 1 31  ? 6.48546   -14.91289 -18.98266 1.000 38.70923 ? 31  ASP B OD2 1 
ATOM   2058 N  N   . TYR B 1 32  ? 4.61808   -9.54897  -18.50534 1.000 8.49842  ? 32  TYR B N   1 
ATOM   2059 C  CA  . TYR B 1 32  ? 5.04265   -8.27543  -17.95241 1.000 8.64835  ? 32  TYR B CA  1 
ATOM   2060 C  C   . TYR B 1 32  ? 3.95670   -7.23060  -17.89741 1.000 8.97335  ? 32  TYR B C   1 
ATOM   2061 O  O   . TYR B 1 32  ? 4.09829   -6.25130  -17.14404 1.000 12.45067 ? 32  TYR B O   1 
ATOM   2062 C  CB  . TYR B 1 32  ? 6.19502   -7.70070  -18.77513 1.000 10.59191 ? 32  TYR B CB  1 
ATOM   2063 C  CG  . TYR B 1 32  ? 7.34399   -8.65704  -18.91713 1.000 8.07716  ? 32  TYR B CG  1 
ATOM   2064 C  CD1 . TYR B 1 32  ? 8.34121   -8.71440  -17.95659 1.000 9.66951  ? 32  TYR B CD1 1 
ATOM   2065 C  CD2 . TYR B 1 32  ? 7.43971   -9.46806  -20.03432 1.000 9.82808  ? 32  TYR B CD2 1 
ATOM   2066 C  CE1 . TYR B 1 32  ? 9.41142   -9.60396  -18.08916 1.000 11.08703 ? 32  TYR B CE1 1 
ATOM   2067 C  CE2 . TYR B 1 32  ? 8.50687   -10.37159 -20.18755 1.000 13.40640 ? 32  TYR B CE2 1 
ATOM   2068 C  CZ  . TYR B 1 32  ? 9.48415   -10.42229 -19.21215 1.000 15.01397 ? 32  TYR B CZ  1 
ATOM   2069 O  OH  . TYR B 1 32  ? 10.53644  -11.31166 -19.38288 1.000 13.26782 ? 32  TYR B OH  1 
ATOM   2070 N  N   . MET B 1 33  ? 2.93649   -7.36746  -18.72932 1.000 7.81397  ? 33  MET B N   1 
ATOM   2071 C  CA  A MET B 1 33  ? 1.87255   -6.37978  -18.89347 0.501 8.86725  ? 33  MET B CA  1 
ATOM   2072 C  CA  B MET B 1 33  ? 1.86558   -6.39087  -18.76863 0.499 8.81808  ? 33  MET B CA  1 
ATOM   2073 C  C   . MET B 1 33  ? 0.54218   -7.10342  -18.95507 1.000 8.62964  ? 33  MET B C   1 
ATOM   2074 O  O   . MET B 1 33  ? 0.45016   -8.18414  -19.55446 1.000 8.76889  ? 33  MET B O   1 
ATOM   2075 C  CB  A MET B 1 33  ? 2.03012   -5.56645  -20.19922 0.501 10.05616 ? 33  MET B CB  1 
ATOM   2076 C  CB  B MET B 1 33  ? 2.07050   -5.35897  -19.88370 0.499 10.95037 ? 33  MET B CB  1 
ATOM   2077 C  CG  A MET B 1 33  ? 3.24310   -4.65663  -20.24092 0.501 11.70961 ? 33  MET B CG  1 
ATOM   2078 C  CG  B MET B 1 33  ? 3.24243   -4.42288  -19.63412 0.499 10.82800 ? 33  MET B CG  1 
ATOM   2079 S  SD  A MET B 1 33  ? 3.07985   -3.23179  -19.15139 0.501 15.23802 ? 33  MET B SD  1 
ATOM   2080 S  SD  B MET B 1 33  ? 3.37827   -3.14736  -20.90201 0.499 13.76289 ? 33  MET B SD  1 
ATOM   2081 C  CE  A MET B 1 33  ? 2.04011   -2.12205  -20.10332 0.501 15.69266 ? 33  MET B CE  1 
ATOM   2082 C  CE  B MET B 1 33  ? 1.81013   -2.28620  -20.74994 0.499 15.44103 ? 33  MET B CE  1 
ATOM   2083 N  N   . GLY B 1 34  ? -0.48056  -6.48863  -18.40692 1.000 7.60465  ? 34  GLY B N   1 
ATOM   2084 C  CA  . GLY B 1 34  ? -1.84714  -6.94506  -18.61382 1.000 9.27929  ? 34  GLY B CA  1 
ATOM   2085 C  C   . GLY B 1 34  ? -2.36376  -7.92913  -17.59767 1.000 8.24449  ? 34  GLY B C   1 
ATOM   2086 O  O   . GLY B 1 34  ? -3.52185  -8.33450  -17.68960 1.000 8.02505  ? 34  GLY B O   1 
ATOM   2087 N  N   . ASN B 1 35  ? -1.52653  -8.34195  -16.64261 1.000 6.82042  ? 35  ASN B N   1 
ATOM   2088 C  CA  . ASN B 1 35  ? -1.93834  -9.23390  -15.55041 1.000 7.52185  ? 35  ASN B CA  1 
ATOM   2089 C  C   . ASN B 1 35  ? -2.72442  -10.44897 -16.05481 1.000 7.16816  ? 35  ASN B C   1 
ATOM   2090 O  O   . ASN B 1 35  ? -3.80728  -10.79725 -15.55696 1.000 9.31759  ? 35  ASN B O   1 
ATOM   2091 C  CB  . ASN B 1 35  ? -2.70183  -8.44945  -14.46261 1.000 7.65737  ? 35  ASN B CB  1 
ATOM   2092 C  CG  . ASN B 1 35  ? -1.77701  -7.55624  -13.68662 1.000 8.47650  ? 35  ASN B CG  1 
ATOM   2093 O  OD1 . ASN B 1 35  ? -1.04259  -8.05724  -12.84394 1.000 8.60477  ? 35  ASN B OD1 1 
ATOM   2094 N  ND2 . ASN B 1 35  ? -1.72852  -6.27775  -14.02775 1.000 7.79192  ? 35  ASN B ND2 1 
ATOM   2095 N  N   . GLY B 1 36  ? -2.12887  -11.12809 -17.06375 1.000 7.72521  ? 36  GLY B N   1 
ATOM   2096 C  CA  . GLY B 1 36  ? -2.66436  -12.34709 -17.61815 1.000 9.08075  ? 36  GLY B CA  1 
ATOM   2097 C  C   . GLY B 1 36  ? -3.71494  -12.18255 -18.69742 1.000 9.23011  ? 36  GLY B C   1 
ATOM   2098 O  O   . GLY B 1 36  ? -4.18026  -13.20061 -19.23077 1.000 12.06573 ? 36  GLY B O   1 
ATOM   2099 N  N   . THR B 1 37  ? -4.10912  -10.94527 -19.04218 1.000 7.16066  ? 37  THR B N   1 
ATOM   2100 C  CA  . THR B 1 37  ? -5.10185  -10.72712 -20.08990 1.000 6.80433  ? 37  THR B CA  1 
ATOM   2101 C  C   . THR B 1 37  ? -4.48191  -10.51363 -21.46012 1.000 7.22043  ? 37  THR B C   1 
ATOM   2102 O  O   . THR B 1 37  ? -5.23297  -10.41479 -22.44554 1.000 7.30683  ? 37  THR B O   1 
ATOM   2103 C  CB  . THR B 1 37  ? -5.99071  -9.50693  -19.77342 1.000 7.92742  ? 37  THR B CB  1 
ATOM   2104 O  OG1 . THR B 1 37  ? -5.21732  -8.31540  -19.83083 1.000 8.48771  ? 37  THR B OG1 1 
ATOM   2105 C  CG2 . THR B 1 37  ? -6.65179  -9.62785  -18.40251 1.000 10.50938 ? 37  THR B CG2 1 
ATOM   2106 N  N   . ARG B 1 38  ? -3.14983  -10.43329 -21.54945 1.000 6.15113  ? 38  ARG B N   1 
ATOM   2107 C  CA  . ARG B 1 38  ? -2.47143  -10.04450 -22.78334 1.000 6.32233  ? 38  ARG B CA  1 
ATOM   2108 C  C   . ARG B 1 38  ? -1.54489  -11.15675 -23.25265 1.000 8.58826  ? 38  ARG B C   1 
ATOM   2109 O  O   . ARG B 1 38  ? -0.90455  -11.83085 -22.43761 1.000 8.29049  ? 38  ARG B O   1 
ATOM   2110 C  CB  . ARG B 1 38  ? -1.68464  -8.75502  -22.58270 1.000 7.72215  ? 38  ARG B CB  1 
ATOM   2111 C  CG  . ARG B 1 38  ? -1.14281  -8.20368  -23.88006 1.000 9.59292  ? 38  ARG B CG  1 
ATOM   2112 C  CD  . ARG B 1 38  ? -0.44391  -6.86435  -23.63668 1.000 12.88032 ? 38  ARG B CD  1 
ATOM   2113 N  NE  . ARG B 1 38  ? -1.41367  -5.89699  -23.13260 1.000 12.01869 ? 38  ARG B NE  1 
ATOM   2114 C  CZ  . ARG B 1 38  ? -1.15421  -4.59956  -23.05884 1.000 15.52047 ? 38  ARG B CZ  1 
ATOM   2115 N  NH1 . ARG B 1 38  ? 0.03438   -4.12374  -23.39143 1.000 14.35299 ? 38  ARG B NH1 1 
ATOM   2116 N  NH2 . ARG B 1 38  ? -2.11248  -3.76158  -22.64767 1.000 13.85315 ? 38  ARG B NH2 1 
ATOM   2117 N  N   . PHE B 1 39  ? -1.46164  -11.32569 -24.56885 1.000 5.59360  ? 39  PHE B N   1 
ATOM   2118 C  CA  . PHE B 1 39  ? -0.64556  -12.34026 -25.21577 1.000 7.97790  ? 39  PHE B CA  1 
ATOM   2119 C  C   . PHE B 1 39  ? 0.12062   -11.64696 -26.32656 1.000 9.13130  ? 39  PHE B C   1 
ATOM   2120 O  O   . PHE B 1 39  ? -0.41280  -10.73880 -26.95162 1.000 8.12114  ? 39  PHE B O   1 
ATOM   2121 C  CB  . PHE B 1 39  ? -1.55537  -13.43938 -25.77417 1.000 7.36511  ? 39  PHE B CB  1 
ATOM   2122 C  CG  . PHE B 1 39  ? -2.42317  -14.04513 -24.72321 1.000 7.81997  ? 39  PHE B CG  1 
ATOM   2123 C  CD1 . PHE B 1 39  ? -3.57179  -13.39349 -24.28346 1.000 8.37833  ? 39  PHE B CD1 1 
ATOM   2124 C  CD2 . PHE B 1 39  ? -2.03706  -15.24923 -24.11498 1.000 12.08226 ? 39  PHE B CD2 1 
ATOM   2125 C  CE1 . PHE B 1 39  ? -4.33736  -13.91288 -23.24599 1.000 10.58298 ? 39  PHE B CE1 1 
ATOM   2126 C  CE2 . PHE B 1 39  ? -2.80521  -15.80344 -23.08485 1.000 13.41852 ? 39  PHE B CE2 1 
ATOM   2127 C  CZ  . PHE B 1 39  ? -3.96640  -15.14633 -22.65105 1.000 13.10688 ? 39  PHE B CZ  1 
ATOM   2128 N  N   . LYS B 1 40  ? 1.38460   -12.03584 -26.54358 1.000 7.21510  ? 40  LYS B N   1 
ATOM   2129 C  CA  . LYS B 1 40  ? 2.26812   -11.18438 -27.32489 1.000 7.46971  ? 40  LYS B CA  1 
ATOM   2130 C  C   . LYS B 1 40  ? 3.35975   -11.95834 -28.03344 1.000 7.57771  ? 40  LYS B C   1 
ATOM   2131 O  O   . LYS B 1 40  ? 3.90201   -12.90379 -27.47205 1.000 8.77865  ? 40  LYS B O   1 
ATOM   2132 C  CB  . LYS B 1 40  ? 2.95340   -10.15950 -26.40230 1.000 15.33836 ? 40  LYS B CB  1 
ATOM   2133 C  CG  . LYS B 1 40  ? 3.89237   -9.21488  -27.10346 1.000 18.05558 ? 40  LYS B CG  1 
ATOM   2134 C  CD  . LYS B 1 40  ? 4.03410   -7.98002  -26.26681 1.000 15.83078 ? 40  LYS B CD  1 
ATOM   2135 C  CE  . LYS B 1 40  ? 4.98224   -7.08068  -26.93626 1.000 24.16726 ? 40  LYS B CE  1 
ATOM   2136 N  NZ  . LYS B 1 40  ? 5.25880   -5.94675  -26.01654 1.000 41.72703 ? 40  LYS B NZ  1 
ATOM   2137 N  N   . ARG B 1 41  ? 3.69679   -11.51536 -29.23795 1.000 6.28385  ? 41  ARG B N   1 
ATOM   2138 C  CA  . ARG B 1 41  ? 4.98611   -11.78437 -29.87560 1.000 6.28724  ? 41  ARG B CA  1 
ATOM   2139 C  C   . ARG B 1 41  ? 5.59105   -10.47615 -30.35935 1.000 6.99533  ? 41  ARG B C   1 
ATOM   2140 O  O   . ARG B 1 41  ? 4.88011   -9.48042  -30.53131 1.000 7.83644  ? 41  ARG B O   1 
ATOM   2141 C  CB  . ARG B 1 41  ? 4.81595   -12.77193 -31.05454 1.000 7.39024  ? 41  ARG B CB  1 
ATOM   2142 C  CG  . ARG B 1 41  ? 4.52483   -14.18457 -30.57037 1.000 8.95039  ? 41  ARG B CG  1 
ATOM   2143 C  CD  . ARG B 1 41  ? 4.38537   -15.12717 -31.79093 1.000 9.54527  ? 41  ARG B CD  1 
ATOM   2144 N  NE  . ARG B 1 41  ? 4.11407   -16.48858 -31.33751 1.000 10.09747 ? 41  ARG B NE  1 
ATOM   2145 C  CZ  . ARG B 1 41  ? 5.06334   -17.36909 -31.08817 1.000 12.73950 ? 41  ARG B CZ  1 
ATOM   2146 N  NH1 . ARG B 1 41  ? 6.32902   -17.09111 -31.31563 1.000 14.10982 ? 41  ARG B NH1 1 
ATOM   2147 N  NH2 . ARG B 1 41  ? 4.72977   -18.55911 -30.58850 1.000 14.73628 ? 41  ARG B NH2 1 
ATOM   2148 N  N   . PHE B 1 42  ? 6.91366   -10.46913 -30.58319 1.000 5.95635  ? 42  PHE B N   1 
ATOM   2149 C  CA  . PHE B 1 42  ? 7.63714   -9.21557  -30.77306 1.000 6.78674  ? 42  PHE B CA  1 
ATOM   2150 C  C   . PHE B 1 42  ? 8.77676   -9.42896  -31.73893 1.000 7.99620  ? 42  PHE B C   1 
ATOM   2151 O  O   . PHE B 1 42  ? 9.53291   -10.38900 -31.57356 1.000 8.46546  ? 42  PHE B O   1 
ATOM   2152 C  CB  . PHE B 1 42  ? 8.18179   -8.73148  -29.42814 1.000 5.96677  ? 42  PHE B CB  1 
ATOM   2153 C  CG  . PHE B 1 42  ? 9.12279   -7.57321  -29.51871 1.000 8.40289  ? 42  PHE B CG  1 
ATOM   2154 C  CD1 . PHE B 1 42  ? 8.65703   -6.28702  -29.77831 1.000 7.18416  ? 42  PHE B CD1 1 
ATOM   2155 C  CD2 . PHE B 1 42  ? 10.48454  -7.74902  -29.23640 1.000 10.10327 ? 42  PHE B CD2 1 
ATOM   2156 C  CE1 . PHE B 1 42  ? 9.55472   -5.20113  -29.77680 1.000 7.89813  ? 42  PHE B CE1 1 
ATOM   2157 C  CE2 . PHE B 1 42  ? 11.36706  -6.65354  -29.25496 1.000 8.71192  ? 42  PHE B CE2 1 
ATOM   2158 C  CZ  . PHE B 1 42  ? 10.89065  -5.39593  -29.52282 1.000 9.06941  ? 42  PHE B CZ  1 
ATOM   2159 N  N   . SER B 1 43  ? 8.88961   -8.55359  -32.74573 1.000 6.44055  ? 43  SER B N   1 
ATOM   2160 C  CA  A SER B 1 43  ? 10.03801  -8.58129  -33.64934 0.913 7.48968  ? 43  SER B CA  1 
ATOM   2161 C  CA  B SER B 1 43  ? 10.01554  -8.59206  -33.66972 0.087 7.56326  ? 43  SER B CA  1 
ATOM   2162 C  C   . SER B 1 43  ? 10.39507  -7.16858  -34.04344 1.000 7.60580  ? 43  SER B C   1 
ATOM   2163 O  O   . SER B 1 43  ? 9.58759   -6.23825  -33.91794 1.000 6.59272  ? 43  SER B O   1 
ATOM   2164 C  CB  A SER B 1 43  ? 9.77527   -9.39328  -34.93128 0.913 9.06930  ? 43  SER B CB  1 
ATOM   2165 C  CB  B SER B 1 43  ? 9.69649   -9.40319  -34.93379 0.087 9.15953  ? 43  SER B CB  1 
ATOM   2166 O  OG  A SER B 1 43  ? 9.66764   -10.78069 -34.64090 0.913 8.91107  ? 43  SER B OG  1 
ATOM   2167 O  OG  B SER B 1 43  ? 8.64308   -8.80618  -35.66593 0.087 9.62407  ? 43  SER B OG  1 
ATOM   2168 N  N   . GLN B 1 44  ? 11.64974  -7.00167  -34.50946 1.000 6.83113  ? 44  GLN B N   1 
ATOM   2169 C  CA  . GLN B 1 44  ? 12.16328  -5.69586  -34.88454 1.000 6.46559  ? 44  GLN B CA  1 
ATOM   2170 C  C   . GLN B 1 44  ? 12.78406  -5.78727  -36.25734 1.000 9.23629  ? 44  GLN B C   1 
ATOM   2171 O  O   . GLN B 1 44  ? 13.32234  -6.83966  -36.61574 1.000 10.80860 ? 44  GLN B O   1 
ATOM   2172 C  CB  . GLN B 1 44  ? 13.18397  -5.21517  -33.89103 1.000 8.45591  ? 44  GLN B CB  1 
ATOM   2173 C  CG  . GLN B 1 44  ? 12.56115  -4.99945  -32.50427 1.000 8.56571  ? 44  GLN B CG  1 
ATOM   2174 C  CD  . GLN B 1 44  ? 13.60949  -4.75450  -31.43444 1.000 9.79533  ? 44  GLN B CD  1 
ATOM   2175 O  OE1 . GLN B 1 44  ? 14.30093  -5.68647  -31.01158 1.000 10.84992 ? 44  GLN B OE1 1 
ATOM   2176 N  NE2 . GLN B 1 44  ? 13.69783  -3.50242  -30.94795 1.000 8.93334  ? 44  GLN B NE2 1 
ATOM   2177 N  N   . TYR B 1 45  ? 12.71742  -4.69150  -37.00009 1.000 9.49630  ? 45  TYR B N   1 
ATOM   2178 C  CA  . TYR B 1 45  ? 13.14703  -4.67636  -38.39473 1.000 11.51437 ? 45  TYR B CA  1 
ATOM   2179 C  C   . TYR B 1 45  ? 13.89532  -3.39801  -38.70229 1.000 12.59479 ? 45  TYR B C   1 
ATOM   2180 O  O   . TYR B 1 45  ? 13.60332  -2.34268  -38.13702 1.000 9.79356  ? 45  TYR B O   1 
ATOM   2181 C  CB  . TYR B 1 45  ? 11.97199  -4.71006  -39.38963 1.000 10.65485 ? 45  TYR B CB  1 
ATOM   2182 C  CG  . TYR B 1 45  ? 11.14146  -5.95478  -39.35783 1.000 9.50497  ? 45  TYR B CG  1 
ATOM   2183 C  CD1 . TYR B 1 45  ? 10.21137  -6.18900  -38.33826 1.000 12.63702 ? 45  TYR B CD1 1 
ATOM   2184 C  CD2 . TYR B 1 45  ? 11.25108  -6.88843  -40.38205 1.000 15.13173 ? 45  TYR B CD2 1 
ATOM   2185 C  CE1 . TYR B 1 45  ? 9.44482   -7.33506  -38.34315 1.000 15.98691 ? 45  TYR B CE1 1 
ATOM   2186 C  CE2 . TYR B 1 45  ? 10.48585  -8.02072  -40.39912 1.000 17.48264 ? 45  TYR B CE2 1 
ATOM   2187 C  CZ  . TYR B 1 45  ? 9.58925   -8.24611  -39.38488 1.000 18.75239 ? 45  TYR B CZ  1 
ATOM   2188 O  OH  . TYR B 1 45  ? 8.86632   -9.41677  -39.46773 1.000 19.60977 ? 45  TYR B OH  1 
ATOM   2189 N  N   . LYS B 1 46  ? 14.83833  -3.48875  -39.65712 1.000 10.96997 ? 46  LYS B N   1 
ATOM   2190 C  CA  . LYS B 1 46  ? 15.34755  -2.30608  -40.32934 1.000 10.56371 ? 46  LYS B CA  1 
ATOM   2191 C  C   . LYS B 1 46  ? 14.50604  -2.03289  -41.57477 1.000 9.33545  ? 46  LYS B C   1 
ATOM   2192 O  O   . LYS B 1 46  ? 14.20540  -2.95866  -42.34226 1.000 14.64078 ? 46  LYS B O   1 
ATOM   2193 C  CB  . LYS B 1 46  ? 16.82541  -2.49865  -40.71334 1.000 14.20323 ? 46  LYS B CB  1 
ATOM   2194 C  CG  . LYS B 1 46  ? 17.38253  -1.27936  -41.46262 1.000 14.19714 ? 46  LYS B CG  1 
ATOM   2195 C  CD  . LYS B 1 46  ? 18.68623  -1.59878  -42.20272 1.000 24.33592 ? 46  LYS B CD  1 
ATOM   2196 C  CE  . LYS B 1 46  ? 19.87303  -1.52297  -41.30855 1.000 20.97983 ? 46  LYS B CE  1 
ATOM   2197 N  NZ  . LYS B 1 46  ? 21.15793  -1.64266  -42.10321 1.000 13.49967 ? 46  LYS B NZ  1 
ATOM   2198 N  N   A LEU B 1 47  ? 14.09872  -0.77788  -41.73737 0.267 11.27836 ? 47  LEU B N   1 
ATOM   2199 N  N   B LEU B 1 47  ? 14.19637  -0.75544  -41.81937 0.733 11.09086 ? 47  LEU B N   1 
ATOM   2200 C  CA  A LEU B 1 47  ? 13.41871  -0.31375  -42.93546 0.267 15.51874 ? 47  LEU B CA  1 
ATOM   2201 C  CA  B LEU B 1 47  ? 13.33875  -0.30665  -42.91864 0.733 15.42837 ? 47  LEU B CA  1 
ATOM   2202 C  C   A LEU B 1 47  ? 14.40651  0.48052   -43.76563 0.267 17.32669 ? 47  LEU B C   1 
ATOM   2203 C  C   B LEU B 1 47  ? 14.13447  0.63570   -43.82490 0.733 16.99673 ? 47  LEU B C   1 
ATOM   2204 O  O   A LEU B 1 47  ? 15.12751  1.33502   -43.23534 0.267 15.92131 ? 47  LEU B O   1 
ATOM   2205 O  O   B LEU B 1 47  ? 14.44372  1.76326   -43.42638 0.733 17.71466 ? 47  LEU B O   1 
ATOM   2206 C  CB  A LEU B 1 47  ? 12.21948  0.57656   -42.61494 0.267 16.83420 ? 47  LEU B CB  1 
ATOM   2207 C  CB  B LEU B 1 47  ? 12.11775  0.42490   -42.36061 0.733 17.86647 ? 47  LEU B CB  1 
ATOM   2208 C  CG  A LEU B 1 47  ? 11.24808  0.12461   -41.54709 0.267 15.87913 ? 47  LEU B CG  1 
ATOM   2209 C  CG  B LEU B 1 47  ? 10.67472  0.15276   -42.72380 0.733 21.36602 ? 47  LEU B CG  1 
ATOM   2210 C  CD1 A LEU B 1 47  ? 9.97930   0.93341   -41.70923 0.267 13.27771 ? 47  LEU B CD1 1 
ATOM   2211 C  CD1 B LEU B 1 47  ? 9.83136   1.37820   -42.29217 0.733 12.94059 ? 47  LEU B CD1 1 
ATOM   2212 C  CD2 A LEU B 1 47  ? 10.98572  -1.34360  -41.71498 0.267 16.00037 ? 47  LEU B CD2 1 
ATOM   2213 C  CD2 B LEU B 1 47  ? 10.46877  -0.22876  -44.19996 0.733 19.12080 ? 47  LEU B CD2 1 
ATOM   2214 N  N   . THR B 1 48  ? 14.43234  0.20331   -45.06319 1.000 21.86595 ? 48  THR B N   1 
ATOM   2215 C  CA  . THR B 1 48  ? 15.28302  0.97356   -45.95302 1.000 26.18986 ? 48  THR B CA  1 
ATOM   2216 C  C   . THR B 1 48  ? 14.53104  1.35885   -47.22054 1.000 21.32421 ? 48  THR B C   1 
ATOM   2217 O  O   . THR B 1 48  ? 13.78403  0.54627   -47.77543 1.000 23.60651 ? 48  THR B O   1 
ATOM   2218 C  CB  . THR B 1 48  ? 16.53928  0.17988   -46.32094 1.000 29.45686 ? 48  THR B CB  1 
ATOM   2219 O  OG1 . THR B 1 48  ? 16.16684  -1.07537  -46.91692 1.000 34.68664 ? 48  THR B OG1 1 
ATOM   2220 C  CG2 . THR B 1 48  ? 17.33697  -0.10655  -45.09979 1.000 21.38434 ? 48  THR B CG2 1 
ATOM   2221 N  N   . PRO B 1 49  ? 14.69537  2.59800   -47.68703 1.000 28.56131 ? 49  PRO B N   1 
ATOM   2222 C  CA  . PRO B 1 49  ? 14.11826  2.98869   -48.97754 1.000 34.67069 ? 49  PRO B CA  1 
ATOM   2223 C  C   . PRO B 1 49  ? 14.72323  2.16086   -50.10061 1.000 32.64734 ? 49  PRO B C   1 
ATOM   2224 O  O   . PRO B 1 49  ? 15.94298  1.99815   -50.18636 1.000 28.91166 ? 49  PRO B O   1 
ATOM   2225 C  CB  . PRO B 1 49  ? 14.49347  4.47295   -49.09934 1.000 34.95405 ? 49  PRO B CB  1 
ATOM   2226 C  CG  . PRO B 1 49  ? 15.71121  4.61988   -48.25366 1.000 36.33753 ? 49  PRO B CG  1 
ATOM   2227 C  CD  . PRO B 1 49  ? 15.47917  3.68743   -47.07942 1.000 31.27650 ? 49  PRO B CD  1 
ATOM   2228 N  N   . ALA B 1 50  ? 13.85836  1.61697   -50.94063 1.000 32.74081 ? 50  ALA B N   1 
ATOM   2229 C  CA  . ALA B 1 50  ? 14.27456  0.80505   -52.06736 1.000 51.51726 ? 50  ALA B CA  1 
ATOM   2230 C  C   . ALA B 1 50  ? 14.00116  1.56485   -53.35344 1.000 51.16480 ? 50  ALA B C   1 
ATOM   2231 O  O   . ALA B 1 50  ? 13.05747  2.35571   -53.43088 1.000 44.14766 ? 50  ALA B O   1 
ATOM   2232 C  CB  . ALA B 1 50  ? 13.53833  -0.53634  -52.08231 1.000 42.04726 ? 50  ALA B CB  1 
ATOM   2233 N  N   . GLU B 1 51  ? 14.84108  1.33190   -54.35903 1.000 59.98155 ? 51  GLU B N   1 
ATOM   2234 C  CA  . GLU B 1 51  ? 14.58883  1.94112   -55.65385 1.000 61.47984 ? 51  GLU B CA  1 
ATOM   2235 C  C   . GLU B 1 51  ? 13.23328  1.46888   -56.18310 1.000 62.15811 ? 51  GLU B C   1 
ATOM   2236 O  O   . GLU B 1 51  ? 12.70273  0.43304   -55.76796 1.000 59.64573 ? 51  GLU B O   1 
ATOM   2237 C  CB  . GLU B 1 51  ? 15.72455  1.62107   -56.63127 1.000 70.75121 ? 51  GLU B CB  1 
ATOM   2238 C  CG  . GLU B 1 51  ? 16.03339  2.75617   -57.61664 1.000 73.16131 ? 51  GLU B CG  1 
ATOM   2239 C  CD  . GLU B 1 51  ? 16.25519  4.10588   -56.93112 1.000 79.72592 ? 51  GLU B CD  1 
ATOM   2240 O  OE1 . GLU B 1 51  ? 16.94728  4.15553   -55.88603 1.000 74.70723 ? 51  GLU B OE1 1 
ATOM   2241 O  OE2 . GLU B 1 51  ? 15.73149  5.12135   -57.44360 1.000 86.29642 ? 51  GLU B OE2 1 
ATOM   2242 N  N   . ASP B 1 52  ? 12.67331  2.25810   -57.10513 1.000 61.94160 ? 52  ASP B N   1 
ATOM   2243 C  CA  . ASP B 1 52  ? 11.27475  2.19605   -57.53453 1.000 61.71346 ? 52  ASP B CA  1 
ATOM   2244 C  C   . ASP B 1 52  ? 10.32528  2.75803   -56.48025 1.000 56.73162 ? 52  ASP B C   1 
ATOM   2245 O  O   . ASP B 1 52  ? 9.12858   2.44302   -56.49054 1.000 54.26377 ? 52  ASP B O   1 
ATOM   2246 C  CB  . ASP B 1 52  ? 10.83858  0.77460   -57.92519 1.000 65.33625 ? 52  ASP B CB  1 
ATOM   2247 C  CG  . ASP B 1 52  ? 11.85751  0.06802   -58.81646 1.000 79.57280 ? 52  ASP B CG  1 
ATOM   2248 O  OD1 . ASP B 1 52  ? 12.37764  0.70157   -59.76518 1.000 76.09343 ? 52  ASP B OD1 1 
ATOM   2249 O  OD2 . ASP B 1 52  ? 12.13786  -1.12676  -58.56796 1.000 77.19514 ? 52  ASP B OD2 1 
ATOM   2250 N  N   . ASP B 1 53  ? 10.84905  3.58005   -55.56528 1.000 56.73525 ? 53  ASP B N   1 
ATOM   2251 C  CA  . ASP B 1 53  ? 10.06489  4.23982   -54.50945 1.000 60.11463 ? 53  ASP B CA  1 
ATOM   2252 C  C   . ASP B 1 53  ? 9.27618   3.23881   -53.66544 1.000 57.75098 ? 53  ASP B C   1 
ATOM   2253 O  O   . ASP B 1 53  ? 8.11099   3.45599   -53.32454 1.000 52.48612 ? 53  ASP B O   1 
ATOM   2254 C  CB  . ASP B 1 53  ? 9.13787   5.31013   -55.08797 1.000 56.21161 ? 53  ASP B CB  1 
ATOM   2255 C  CG  . ASP B 1 53  ? 9.86814   6.59953   -55.41052 1.000 65.40834 ? 53  ASP B CG  1 
ATOM   2256 O  OD1 . ASP B 1 53  ? 11.12216  6.60533   -55.39068 1.000 61.94823 ? 53  ASP B OD1 1 
ATOM   2257 O  OD2 . ASP B 1 53  ? 9.18248   7.61022   -55.67151 1.000 60.73333 ? 53  ASP B OD2 1 
ATOM   2258 N  N   . THR B 1 54  ? 9.92414   2.13825   -53.31476 1.000 55.73356 ? 54  THR B N   1 
ATOM   2259 C  CA  . THR B 1 54  ? 9.37376   1.14647   -52.40326 1.000 42.71459 ? 54  THR B CA  1 
ATOM   2260 C  C   . THR B 1 54  ? 10.22953  1.12726   -51.13798 1.000 32.11930 ? 54  THR B C   1 
ATOM   2261 O  O   . THR B 1 54  ? 11.12768  1.95555   -50.96080 1.000 33.66171 ? 54  THR B O   1 
ATOM   2262 C  CB  . THR B 1 54  ? 9.31334   -0.22381  -53.07725 1.000 44.77783 ? 54  THR B CB  1 
ATOM   2263 O  OG1 . THR B 1 54  ? 10.64511  -0.69351  -53.32376 1.000 59.44726 ? 54  THR B OG1 1 
ATOM   2264 C  CG2 . THR B 1 54  ? 8.57753   -0.11612  -54.40168 1.000 50.99654 ? 54  THR B CG2 1 
ATOM   2265 N  N   . TRP B 1 55  ? 9.93978   0.17279   -50.25090 1.000 34.43385 ? 55  TRP B N   1 
ATOM   2266 C  CA  . TRP B 1 55  ? 10.67160  0.01718   -49.00036 1.000 26.43602 ? 55  TRP B CA  1 
ATOM   2267 C  C   . TRP B 1 55  ? 11.04562  -1.43702  -48.79762 1.000 27.76061 ? 55  TRP B C   1 
ATOM   2268 O  O   . TRP B 1 55  ? 10.25947  -2.33102  -49.10066 1.000 31.08578 ? 55  TRP B O   1 
ATOM   2269 C  CB  . TRP B 1 55  ? 9.85408   0.48543   -47.79201 1.000 31.10370 ? 55  TRP B CB  1 
ATOM   2270 C  CG  . TRP B 1 55  ? 9.68848   1.94458   -47.74956 1.000 28.28928 ? 55  TRP B CG  1 
ATOM   2271 C  CD1 . TRP B 1 55  ? 8.75105   2.68508   -48.41461 1.000 31.11672 ? 55  TRP B CD1 1 
ATOM   2272 C  CD2 . TRP B 1 55  ? 10.48305  2.86723   -47.01171 1.000 23.16321 ? 55  TRP B CD2 1 
ATOM   2273 N  NE1 . TRP B 1 55  ? 8.91774   4.01360   -48.13186 1.000 29.88502 ? 55  TRP B NE1 1 
ATOM   2274 C  CE2 . TRP B 1 55  ? 9.97620   4.15448   -47.27436 1.000 24.07807 ? 55  TRP B CE2 1 
ATOM   2275 C  CE3 . TRP B 1 55  ? 11.58290  2.73533   -46.15819 1.000 23.43828 ? 55  TRP B CE3 1 
ATOM   2276 C  CZ2 . TRP B 1 55  ? 10.52759  5.29748   -46.70714 1.000 22.24043 ? 55  TRP B CZ2 1 
ATOM   2277 C  CZ3 . TRP B 1 55  ? 12.12016  3.86129   -45.59253 1.000 23.53791 ? 55  TRP B CZ3 1 
ATOM   2278 C  CH2 . TRP B 1 55  ? 11.59936  5.13553   -45.87737 1.000 22.86060 ? 55  TRP B CH2 1 
ATOM   2279 N  N   . SER B 1 56  ? 12.24024  -1.65191  -48.25435 1.000 25.81047 ? 56  SER B N   1 
ATOM   2280 C  CA  . SER B 1 56  ? 12.77985  -2.97397  -47.97336 1.000 27.21055 ? 56  SER B CA  1 
ATOM   2281 C  C   . SER B 1 56  ? 12.77417  -3.22266  -46.46548 1.000 22.92386 ? 56  SER B C   1 
ATOM   2282 O  O   . SER B 1 56  ? 13.12433  -2.33085  -45.68186 1.000 21.62905 ? 56  SER B O   1 
ATOM   2283 C  CB  . SER B 1 56  ? 14.20792  -3.08661  -48.53152 1.000 28.60751 ? 56  SER B CB  1 
ATOM   2284 O  OG  . SER B 1 56  ? 14.89655  -4.19963  -47.98778 1.000 44.12775 ? 56  SER B OG  1 
ATOM   2285 N  N   . PHE B 1 57  ? 12.36164  -4.42501  -46.06286 1.000 17.21760 ? 57  PHE B N   1 
ATOM   2286 C  CA  . PHE B 1 57  ? 12.29844  -4.79913  -44.64967 1.000 17.48839 ? 57  PHE B CA  1 
ATOM   2287 C  C   . PHE B 1 57  ? 13.35173  -5.85753  -44.37092 1.000 24.66124 ? 57  PHE B C   1 
ATOM   2288 O  O   . PHE B 1 57  ? 13.43839  -6.84430  -45.10707 1.000 24.38562 ? 57  PHE B O   1 
ATOM   2289 C  CB  . PHE B 1 57  ? 10.94419  -5.38452  -44.27147 1.000 14.95002 ? 57  PHE B CB  1 
ATOM   2290 C  CG  . PHE B 1 57  ? 9.80552   -4.42181  -44.32000 1.000 14.60029 ? 57  PHE B CG  1 
ATOM   2291 C  CD1 . PHE B 1 57  ? 9.20236   -4.10669  -45.51823 1.000 19.22623 ? 57  PHE B CD1 1 
ATOM   2292 C  CD2 . PHE B 1 57  ? 9.28683   -3.89058  -43.14980 1.000 15.05226 ? 57  PHE B CD2 1 
ATOM   2293 C  CE1 . PHE B 1 57  ? 8.10326   -3.22980  -45.56721 1.000 22.12102 ? 57  PHE B CE1 1 
ATOM   2294 C  CE2 . PHE B 1 57  ? 8.19993   -3.02673  -43.18235 1.000 18.10200 ? 57  PHE B CE2 1 
ATOM   2295 C  CZ  . PHE B 1 57  ? 7.60547   -2.68940  -44.39857 1.000 15.45309 ? 57  PHE B CZ  1 
ATOM   2296 N  N   . LYS B 1 58  ? 14.11445  -5.68798  -43.29019 1.000 14.12662 ? 58  LYS B N   1 
ATOM   2297 C  CA  . LYS B 1 58  ? 15.07938  -6.69717  -42.84830 1.000 16.75763 ? 58  LYS B CA  1 
ATOM   2298 C  C   . LYS B 1 58  ? 14.82148  -7.03234  -41.38665 1.000 11.79674 ? 58  LYS B C   1 
ATOM   2299 O  O   . LYS B 1 58  ? 14.96571  -6.16100  -40.52971 1.000 14.26661 ? 58  LYS B O   1 
ATOM   2300 C  CB  . LYS B 1 58  ? 16.52740  -6.21015  -43.02273 1.000 22.32911 ? 58  LYS B CB  1 
ATOM   2301 C  CG  . LYS B 1 58  ? 17.60943  -7.24265  -42.71830 1.000 27.83136 ? 58  LYS B CG  1 
ATOM   2302 C  CD  . LYS B 1 58  ? 17.71503  -8.20596  -43.87433 1.000 43.39256 ? 58  LYS B CD  1 
ATOM   2303 C  CE  . LYS B 1 58  ? 18.06616  -9.65191  -43.40074 1.000 47.41541 ? 58  LYS B CE  1 
ATOM   2304 N  NZ  . LYS B 1 58  ? 16.85408  -10.50744 -43.25688 1.000 51.35691 ? 58  LYS B NZ  1 
ATOM   2305 N  N   . ARG B 1 59  ? 14.49110  -8.28517  -41.09340 1.000 13.43480 ? 59  ARG B N   1 
ATOM   2306 C  CA  . ARG B 1 59  ? 14.29126  -8.66763  -39.69701 1.000 14.48588 ? 59  ARG B CA  1 
ATOM   2307 C  C   . ARG B 1 59  ? 15.63400  -8.63896  -38.98415 1.000 16.99093 ? 59  ARG B C   1 
ATOM   2308 O  O   . ARG B 1 59  ? 16.63076  -9.18118  -39.47591 1.000 18.83441 ? 59  ARG B O   1 
ATOM   2309 C  CB  . ARG B 1 59  ? 13.64502  -10.05724 -39.55469 1.000 15.29427 ? 59  ARG B CB  1 
ATOM   2310 C  CG  . ARG B 1 59  ? 13.15305  -10.37915 -38.11525 1.000 19.68039 ? 59  ARG B CG  1 
ATOM   2311 C  CD  . ARG B 1 59  ? 12.53251  -11.79603 -37.99234 1.000 29.41410 ? 59  ARG B CD  1 
ATOM   2312 N  NE  . ARG B 1 59  ? 11.23917  -11.92404 -38.66272 1.000 44.05726 ? 59  ARG B NE  1 
ATOM   2313 C  CZ  . ARG B 1 59  ? 10.13626  -12.41525 -38.10432 1.000 38.59100 ? 59  ARG B CZ  1 
ATOM   2314 N  NH1 . ARG B 1 59  ? 10.13187  -12.87681 -36.86699 1.000 23.49325 ? 59  ARG B NH1 1 
ATOM   2315 N  NH2 . ARG B 1 59  ? 9.01172   -12.46410 -38.81607 1.000 35.39862 ? 59  ARG B NH2 1 
ATOM   2316 N  N   . LEU B 1 60  ? 15.67458  -7.97306  -37.84636 1.000 10.93974 ? 60  LEU B N   1 
ATOM   2317 C  CA  . LEU B 1 60  ? 16.87188  -7.88481  -37.02989 1.000 8.65128  ? 60  LEU B CA  1 
ATOM   2318 C  C   . LEU B 1 60  ? 17.01036  -9.07413  -36.07468 1.000 11.17290 ? 60  LEU B C   1 
ATOM   2319 O  O   . LEU B 1 60  ? 16.02379  -9.73209  -35.71124 1.000 11.92754 ? 60  LEU B O   1 
ATOM   2320 C  CB  . LEU B 1 60  ? 16.84177  -6.59432  -36.21158 1.000 9.97503  ? 60  LEU B CB  1 
ATOM   2321 C  CG  . LEU B 1 60  ? 16.85910  -5.30695  -37.02131 1.000 12.59190 ? 60  LEU B CG  1 
ATOM   2322 C  CD1 . LEU B 1 60  ? 16.54734  -4.07213  -36.14959 1.000 12.49575 ? 60  LEU B CD1 1 
ATOM   2323 C  CD2 . LEU B 1 60  ? 18.21917  -5.15895  -37.67957 1.000 17.40622 ? 60  LEU B CD2 1 
ATOM   2324 N  N   . PRO B 1 61  ? 18.23499  -9.37414  -35.61600 1.000 12.98405 ? 61  PRO B N   1 
ATOM   2325 C  CA  . PRO B 1 61  ? 18.41000  -10.46477 -34.64022 1.000 10.94863 ? 61  PRO B CA  1 
ATOM   2326 C  C   . PRO B 1 61  ? 17.54988  -10.22994 -33.39838 1.000 13.88852 ? 61  PRO B C   1 
ATOM   2327 O  O   . PRO B 1 61  ? 17.42479  -9.10657  -32.89995 1.000 15.22645 ? 61  PRO B O   1 
ATOM   2328 C  CB  . PRO B 1 61  ? 19.90898  -10.42226 -34.32719 1.000 13.31905 ? 61  PRO B CB  1 
ATOM   2329 C  CG  . PRO B 1 61  ? 20.50205  -9.92161  -35.57791 1.000 16.77866 ? 61  PRO B CG  1 
ATOM   2330 C  CD  . PRO B 1 61  ? 19.52736  -8.89141  -36.14249 1.000 17.76408 ? 61  PRO B CD  1 
ATOM   2331 N  N   . HIS B 1 62  ? 16.93879  -11.30208 -32.92058 1.000 15.12583 ? 62  HIS B N   1 
ATOM   2332 C  CA  . HIS B 1 62  ? 15.93231  -11.18653 -31.87503 1.000 12.61411 ? 62  HIS B CA  1 
ATOM   2333 C  C   . HIS B 1 62  ? 16.54203  -10.76619 -30.53783 1.000 14.40017 ? 62  HIS B C   1 
ATOM   2334 O  O   . HIS B 1 62  ? 17.50079  -11.37415 -30.05474 1.000 14.51632 ? 62  HIS B O   1 
ATOM   2335 C  CB  . HIS B 1 62  ? 15.19791  -12.50869 -31.73417 1.000 12.34863 ? 62  HIS B CB  1 
ATOM   2336 C  CG  . HIS B 1 62  ? 14.01067  -12.42527 -30.82426 1.000 12.21015 ? 62  HIS B CG  1 
ATOM   2337 N  ND1 . HIS B 1 62  ? 12.86139  -11.75075 -31.17190 1.000 15.03891 ? 62  HIS B ND1 1 
ATOM   2338 C  CD2 . HIS B 1 62  ? 13.80356  -12.92379 -29.58614 1.000 13.90679 ? 62  HIS B CD2 1 
ATOM   2339 C  CE1 . HIS B 1 62  ? 11.97977  -11.86291 -30.19245 1.000 12.12058 ? 62  HIS B CE1 1 
ATOM   2340 N  NE2 . HIS B 1 62  ? 12.52846  -12.56539 -29.21552 1.000 15.36673 ? 62  HIS B NE2 1 
ATOM   2341 N  N   . ARG B 1 63  ? 15.95861  -9.73101  -29.92371 1.000 11.39652 ? 63  ARG B N   1 
ATOM   2342 C  CA  . ARG B 1 63  ? 16.45044  -9.15169  -28.68240 1.000 12.59351 ? 63  ARG B CA  1 
ATOM   2343 C  C   . ARG B 1 63  ? 15.27224  -8.88406  -27.76621 1.000 10.59912 ? 63  ARG B C   1 
ATOM   2344 O  O   . ARG B 1 63  ? 14.14974  -8.65002  -28.23681 1.000 12.67103 ? 63  ARG B O   1 
ATOM   2345 C  CB  . ARG B 1 63  ? 17.18922  -7.82123  -28.90234 1.000 13.18279 ? 63  ARG B CB  1 
ATOM   2346 C  CG  . ARG B 1 63  ? 18.49339  -7.98682  -29.68169 1.000 14.23126 ? 63  ARG B CG  1 
ATOM   2347 C  CD  . ARG B 1 63  ? 19.16805  -6.65207  -29.82634 1.000 16.36261 ? 63  ARG B CD  1 
ATOM   2348 N  NE  . ARG B 1 63  ? 19.66664  -6.12616  -28.55606 1.000 17.58768 ? 63  ARG B NE  1 
ATOM   2349 C  CZ  . ARG B 1 63  ? 20.93153  -6.17236  -28.15236 1.000 20.68245 ? 63  ARG B CZ  1 
ATOM   2350 N  NH1 . ARG B 1 63  ? 21.86165  -6.82934  -28.83643 1.000 20.73421 ? 63  ARG B NH1 1 
ATOM   2351 N  NH2 . ARG B 1 63  ? 21.28311  -5.51787  -27.05003 1.000 18.78733 ? 63  ARG B NH2 1 
ATOM   2352 N  N   . ASP B 1 64  ? 15.55410  -8.87843  -26.45843 1.000 10.54522 ? 64  ASP B N   1 
ATOM   2353 C  CA  . ASP B 1 64  ? 14.53695  -8.48485  -25.48312 1.000 11.75018 ? 64  ASP B CA  1 
ATOM   2354 C  C   . ASP B 1 64  ? 14.02217  -7.08436  -25.79316 1.000 11.74565 ? 64  ASP B C   1 
ATOM   2355 O  O   . ASP B 1 64  ? 14.76681  -6.20343  -26.21760 1.000 12.13962 ? 64  ASP B O   1 
ATOM   2356 C  CB  . ASP B 1 64  ? 15.09851  -8.47053  -24.06424 1.000 10.91052 ? 64  ASP B CB  1 
ATOM   2357 C  CG  . ASP B 1 64  ? 15.63475  -9.79929  -23.61373 1.000 19.49489 ? 64  ASP B CG  1 
ATOM   2358 O  OD1 . ASP B 1 64  ? 15.22717  -10.86952 -24.14104 1.000 17.09756 ? 64  ASP B OD1 1 
ATOM   2359 O  OD2 . ASP B 1 64  ? 16.45795  -9.75082  -22.66005 1.000 21.53649 ? 64  ASP B OD2 1 
ATOM   2360 N  N   . TYR B 1 65  ? 12.73771  -6.87061  -25.53281 1.000 10.18034 ? 65  TYR B N   1 
ATOM   2361 C  CA  . TYR B 1 65  ? 12.18090  -5.52770  -25.64002 1.000 8.03332  ? 65  TYR B CA  1 
ATOM   2362 C  C   . TYR B 1 65  ? 12.53140  -4.70502  -24.40749 1.000 10.76492 ? 65  TYR B C   1 
ATOM   2363 O  O   . TYR B 1 65  ? 12.36369  -5.18059  -23.27646 1.000 10.31203 ? 65  TYR B O   1 
ATOM   2364 C  CB  . TYR B 1 65  ? 10.66307  -5.60004  -25.77591 1.000 8.81552  ? 65  TYR B CB  1 
ATOM   2365 C  CG  . TYR B 1 65  ? 9.97099   -4.26552  -25.80045 1.000 8.67357  ? 65  TYR B CG  1 
ATOM   2366 C  CD1 . TYR B 1 65  ? 10.32187  -3.28058  -26.71714 1.000 7.68530  ? 65  TYR B CD1 1 
ATOM   2367 C  CD2 . TYR B 1 65  ? 8.91496   -4.00680  -24.93155 1.000 9.79001  ? 65  TYR B CD2 1 
ATOM   2368 C  CE1 . TYR B 1 65  ? 9.64853   -2.06603  -26.76395 1.000 8.82471  ? 65  TYR B CE1 1 
ATOM   2369 C  CE2 . TYR B 1 65  ? 8.23817   -2.76440  -24.96748 1.000 9.64770  ? 65  TYR B CE2 1 
ATOM   2370 C  CZ  . TYR B 1 65  ? 8.62201   -1.82626  -25.87288 1.000 8.82962  ? 65  TYR B CZ  1 
ATOM   2371 O  OH  . TYR B 1 65  ? 7.97530   -0.60565  -25.89609 1.000 12.96792 ? 65  TYR B OH  1 
ATOM   2372 N  N   . THR B 1 66  ? 12.97239  -3.46648  -24.62601 1.000 10.52032 ? 66  THR B N   1 
ATOM   2373 C  CA  . THR B 1 66  ? 13.23501  -2.53889  -23.52809 1.000 9.69479  ? 66  THR B CA  1 
ATOM   2374 C  C   . THR B 1 66  ? 12.65113  -1.18400  -23.89220 1.000 8.77476  ? 66  THR B C   1 
ATOM   2375 O  O   . THR B 1 66  ? 12.77539  -0.71373  -25.03332 1.000 10.66280 ? 66  THR B O   1 
ATOM   2376 C  CB  . THR B 1 66  ? 14.74155  -2.40521  -23.22821 1.000 12.40784 ? 66  THR B CB  1 
ATOM   2377 O  OG1 . THR B 1 66  ? 15.41624  -1.93548  -24.41665 1.000 14.67039 ? 66  THR B OG1 1 
ATOM   2378 C  CG2 . THR B 1 66  ? 15.31928  -3.74832  -22.81649 1.000 13.32760 ? 66  THR B CG2 1 
ATOM   2379 N  N   . THR B 1 67  ? 11.92811  -0.58486  -22.94321 1.000 9.74003  ? 67  THR B N   1 
ATOM   2380 C  CA  . THR B 1 67  ? 11.45995  0.77485   -23.11175 1.000 9.01215  ? 67  THR B CA  1 
ATOM   2381 C  C   . THR B 1 67  ? 11.76314  1.53480   -21.83123 1.000 8.50968  ? 67  THR B C   1 
ATOM   2382 O  O   . THR B 1 67  ? 12.26368  0.96958   -20.85075 1.000 10.33915 ? 67  THR B O   1 
ATOM   2383 C  CB  . THR B 1 67  ? 9.96079   0.83801   -23.49275 1.000 11.55373 ? 67  THR B CB  1 
ATOM   2384 O  OG1 . THR B 1 67  ? 9.59421   2.20803   -23.73092 1.000 11.94704 ? 67  THR B OG1 1 
ATOM   2385 C  CG2 . THR B 1 67  ? 9.06266   0.25781   -22.40966 1.000 13.47994 ? 67  THR B CG2 1 
ATOM   2386 N  N   . TYR B 1 68  ? 11.49469  2.83483   -21.87501 1.000 11.27669 ? 68  TYR B N   1 
ATOM   2387 C  CA  . TYR B 1 68  ? 11.84222  3.75289   -20.78652 1.000 10.93829 ? 68  TYR B CA  1 
ATOM   2388 C  C   . TYR B 1 68  ? 10.67136  3.92848   -19.83490 1.000 13.92671 ? 68  TYR B C   1 
ATOM   2389 O  O   . TYR B 1 68  ? 9.53947   4.07054   -20.27581 1.000 12.05091 ? 68  TYR B O   1 
ATOM   2390 C  CB  . TYR B 1 68  ? 12.18557  5.12298   -21.33011 1.000 13.17398 ? 68  TYR B CB  1 
ATOM   2391 C  CG  . TYR B 1 68  ? 13.39665  5.22992   -22.22090 1.000 11.71099 ? 68  TYR B CG  1 
ATOM   2392 C  CD1 . TYR B 1 68  ? 13.31682  4.92646   -23.57759 1.000 13.73030 ? 68  TYR B CD1 1 
ATOM   2393 C  CD2 . TYR B 1 68  ? 14.60661  5.71795   -21.71954 1.000 16.46945 ? 68  TYR B CD2 1 
ATOM   2394 C  CE1 . TYR B 1 68  ? 14.39915  5.06238   -24.40535 1.000 15.72944 ? 68  TYR B CE1 1 
ATOM   2395 C  CE2 . TYR B 1 68  ? 15.70966  5.85671   -22.54383 1.000 16.20605 ? 68  TYR B CE2 1 
ATOM   2396 C  CZ  . TYR B 1 68  ? 15.59239  5.53177   -23.88587 1.000 19.60227 ? 68  TYR B CZ  1 
ATOM   2397 O  OH  . TYR B 1 68  ? 16.67416  5.68522   -24.70939 1.000 17.89273 ? 68  TYR B OH  1 
ATOM   2398 N  N   . LYS B 1 69  ? 10.96291  3.98396   -18.53447 1.000 12.24607 ? 69  LYS B N   1 
ATOM   2399 C  CA  . LYS B 1 69  ? 9.89170   4.26069   -17.58184 1.000 13.90156 ? 69  LYS B CA  1 
ATOM   2400 C  C   . LYS B 1 69  ? 9.26224   5.62374   -17.83418 1.000 14.53271 ? 69  LYS B C   1 
ATOM   2401 O  O   . LYS B 1 69  ? 8.07585   5.82291   -17.54177 1.000 13.22125 ? 69  LYS B O   1 
ATOM   2402 C  CB  . LYS B 1 69  ? 10.40900  4.18691   -16.14209 1.000 13.37498 ? 69  LYS B CB  1 
ATOM   2403 C  CG  . LYS B 1 69  ? 10.63394  2.78957   -15.65673 1.000 20.12099 ? 69  LYS B CG  1 
ATOM   2404 C  CD  . LYS B 1 69  ? 11.00918  2.78607   -14.18223 1.000 25.51561 ? 69  LYS B CD  1 
ATOM   2405 C  CE  . LYS B 1 69  ? 11.11443  1.35911   -13.64024 1.000 36.25306 ? 69  LYS B CE  1 
ATOM   2406 N  NZ  . LYS B 1 69  ? 11.14281  1.30126   -12.13238 1.000 37.11782 ? 69  LYS B NZ  1 
ATOM   2407 N  N   . LYS B 1 70  ? 10.03221  6.57916   -18.36535 1.000 14.08412 ? 70  LYS B N   1 
ATOM   2408 C  CA  . LYS B 1 70  ? 9.47793   7.90255   -18.63082 1.000 17.30773 ? 70  LYS B CA  1 
ATOM   2409 C  C   . LYS B 1 70  ? 8.36718   7.88381   -19.67856 1.000 15.55782 ? 70  LYS B C   1 
ATOM   2410 O  O   . LYS B 1 70  ? 7.55627   8.81294   -19.71241 1.000 20.75214 ? 70  LYS B O   1 
ATOM   2411 C  CB  . LYS B 1 70  ? 10.59985  8.85996   -19.04329 1.000 18.51468 ? 70  LYS B CB  1 
ATOM   2412 C  CG  . LYS B 1 70  ? 11.18408  8.61497   -20.40265 1.000 17.10891 ? 70  LYS B CG  1 
ATOM   2413 C  CD  . LYS B 1 70  ? 12.30344  9.60512   -20.73316 1.000 25.03181 ? 70  LYS B CD  1 
ATOM   2414 C  CE  . LYS B 1 70  ? 12.96812  9.24646   -22.06233 1.000 32.48920 ? 70  LYS B CE  1 
ATOM   2415 N  NZ  . LYS B 1 70  ? 14.08030  10.19147  -22.43466 1.000 34.47291 ? 70  LYS B NZ  1 
ATOM   2416 N  N   . PHE B 1 71  ? 8.28777   6.84836   -20.52410 1.000 12.31337 ? 71  PHE B N   1 
ATOM   2417 C  CA  . PHE B 1 71  ? 7.16226   6.70003   -21.44959 1.000 13.25979 ? 71  PHE B CA  1 
ATOM   2418 C  C   . PHE B 1 71  ? 6.16206   5.66342   -20.97697 1.000 16.04845 ? 71  PHE B C   1 
ATOM   2419 O  O   . PHE B 1 71  ? 4.94731   5.82763   -21.17105 1.000 15.61673 ? 71  PHE B O   1 
ATOM   2420 C  CB  . PHE B 1 71  ? 7.62425   6.29955   -22.85425 1.000 14.50534 ? 71  PHE B CB  1 
ATOM   2421 C  CG  . PHE B 1 71  ? 8.60743   7.24805   -23.46578 1.000 13.62393 ? 71  PHE B CG  1 
ATOM   2422 C  CD1 . PHE B 1 71  ? 8.26647   8.56316   -23.72552 1.000 13.88854 ? 71  PHE B CD1 1 
ATOM   2423 C  CD2 . PHE B 1 71  ? 9.87858   6.80991   -23.78636 1.000 17.32610 ? 71  PHE B CD2 1 
ATOM   2424 C  CE1 . PHE B 1 71  ? 9.20286   9.42994   -24.30698 1.000 17.03465 ? 71  PHE B CE1 1 
ATOM   2425 C  CE2 . PHE B 1 71  ? 10.80728  7.66081   -24.34750 1.000 17.47955 ? 71  PHE B CE2 1 
ATOM   2426 C  CZ  . PHE B 1 71  ? 10.46579  8.97098   -24.60226 1.000 16.82892 ? 71  PHE B CZ  1 
ATOM   2427 N  N   . ASN B 1 72  ? 6.64615   4.59410   -20.35396 1.000 12.65899 ? 72  ASN B N   1 
ATOM   2428 C  CA  . ASN B 1 72  ? 5.80635   3.47939   -19.92874 1.000 9.88622  ? 72  ASN B CA  1 
ATOM   2429 C  C   . ASN B 1 72  ? 6.17219   3.17714   -18.48152 1.000 12.59448 ? 72  ASN B C   1 
ATOM   2430 O  O   . ASN B 1 72  ? 7.11953   2.42491   -18.19520 1.000 13.17405 ? 72  ASN B O   1 
ATOM   2431 C  CB  . ASN B 1 72  ? 6.02030   2.26076   -20.81910 1.000 11.11895 ? 72  ASN B CB  1 
ATOM   2432 C  CG  . ASN B 1 72  ? 5.15043   1.09704   -20.40604 1.000 15.28906 ? 72  ASN B CG  1 
ATOM   2433 O  OD1 . ASN B 1 72  ? 4.54699   1.09651   -19.32733 1.000 14.95906 ? 72  ASN B OD1 1 
ATOM   2434 N  ND2 . ASN B 1 72  ? 5.07588   0.07548   -21.27738 1.000 15.50492 ? 72  ASN B ND2 1 
ATOM   2435 N  N   . PRO B 1 73  ? 5.42307   3.73495   -17.53116 1.000 13.92474 ? 73  PRO B N   1 
ATOM   2436 C  CA  . PRO B 1 73  ? 5.77188   3.55192   -16.11900 1.000 15.07955 ? 73  PRO B CA  1 
ATOM   2437 C  C   . PRO B 1 73  ? 5.51882   2.14808   -15.58490 1.000 15.99264 ? 73  PRO B C   1 
ATOM   2438 O  O   . PRO B 1 73  ? 6.11666   1.78446   -14.57068 1.000 22.48390 ? 73  PRO B O   1 
ATOM   2439 C  CB  . PRO B 1 73  ? 4.88469   4.59349   -15.41226 1.000 18.27238 ? 73  PRO B CB  1 
ATOM   2440 C  CG  . PRO B 1 73  ? 3.71392   4.82426   -16.37103 1.000 23.20157 ? 73  PRO B CG  1 
ATOM   2441 C  CD  . PRO B 1 73  ? 4.33520   4.70632   -17.74772 1.000 17.74173 ? 73  PRO B CD  1 
ATOM   2442 N  N   A VAL B 1 74  ? 4.70209   1.33865   -16.25920 0.556 11.95992 ? 74  VAL B N   1 
ATOM   2443 N  N   B VAL B 1 74  ? 4.62577   1.36241   -16.18282 0.444 12.01374 ? 74  VAL B N   1 
ATOM   2444 C  CA  A VAL B 1 74  ? 4.29205   0.02014   -15.77466 0.556 12.60629 ? 74  VAL B CA  1 
ATOM   2445 C  CA  B VAL B 1 74  ? 4.41091   0.00773   -15.67366 0.444 12.44679 ? 74  VAL B CA  1 
ATOM   2446 C  C   A VAL B 1 74  ? 5.11140   -1.09037  -16.42515 0.556 13.38689 ? 74  VAL B C   1 
ATOM   2447 C  C   B VAL B 1 74  ? 5.35676   -0.99512  -16.32770 0.444 13.31816 ? 74  VAL B C   1 
ATOM   2448 O  O   A VAL B 1 74  ? 5.22498   -2.19704  -15.87578 0.556 14.46755 ? 74  VAL B O   1 
ATOM   2449 O  O   B VAL B 1 74  ? 5.82459   -1.92819  -15.66650 0.444 17.54087 ? 74  VAL B O   1 
ATOM   2450 C  CB  A VAL B 1 74  ? 2.78543   -0.18208  -16.03997 0.556 13.05399 ? 74  VAL B CB  1 
ATOM   2451 C  CB  B VAL B 1 74  ? 2.93435   -0.42293  -15.84207 0.444 11.65543 ? 74  VAL B CB  1 
ATOM   2452 C  CG1 A VAL B 1 74  ? 2.32855   -1.53388  -15.63216 0.556 15.09325 ? 74  VAL B CG1 1 
ATOM   2453 C  CG1 B VAL B 1 74  ? 2.36014   0.02918   -17.17815 0.444 11.72875 ? 74  VAL B CG1 1 
ATOM   2454 C  CG2 A VAL B 1 74  ? 1.96574   0.88876   -15.31909 0.556 13.20429 ? 74  VAL B CG2 1 
ATOM   2455 C  CG2 B VAL B 1 74  ? 2.77695   -1.91179  -15.72325 0.444 18.57273 ? 74  VAL B CG2 1 
ATOM   2456 N  N   . GLY B 1 75  ? 5.67567   -0.81627  -17.60030 1.000 12.39442 ? 75  GLY B N   1 
ATOM   2457 C  CA  . GLY B 1 75  ? 6.46108   -1.83117  -18.30120 1.000 12.22199 ? 75  GLY B CA  1 
ATOM   2458 C  C   . GLY B 1 75  ? 7.82237   -1.37223  -18.76850 1.000 13.11493 ? 75  GLY B C   1 
ATOM   2459 O  O   . GLY B 1 75  ? 8.47093   -2.07290  -19.56166 1.000 10.46950 ? 75  GLY B O   1 
ATOM   2460 N  N   . GLY B 1 76  ? 8.26215   -0.19769  -18.29234 1.000 10.31591 ? 76  GLY B N   1 
ATOM   2461 C  CA  . GLY B 1 76  ? 9.53433   0.36623   -18.66402 1.000 8.35133  ? 76  GLY B CA  1 
ATOM   2462 C  C   . GLY B 1 76  ? 10.65368  -0.02405  -17.71037 1.000 10.96877 ? 76  GLY B C   1 
ATOM   2463 O  O   . GLY B 1 76  ? 10.45414  -0.51999  -16.59595 1.000 12.56596 ? 76  GLY B O   1 
ATOM   2464 N  N   . GLY B 1 77  ? 11.87798  0.15431   -18.18911 1.000 11.86777 ? 77  GLY B N   1 
ATOM   2465 C  CA  . GLY B 1 77  ? 13.04640  -0.05969  -17.35374 1.000 11.73269 ? 77  GLY B CA  1 
ATOM   2466 C  C   . GLY B 1 77  ? 13.38871  -1.50096  -17.06235 1.000 13.63122 ? 77  GLY B C   1 
ATOM   2467 O  O   . GLY B 1 77  ? 14.21748  -1.74611  -16.17624 1.000 18.97736 ? 77  GLY B O   1 
ATOM   2468 N  N   . ILE B 1 78  ? 12.83380  -2.46437  -17.80479 1.000 11.28648 ? 78  ILE B N   1 
ATOM   2469 C  CA  . ILE B 1 78  ? 13.13272  -3.87732  -17.59838 1.000 11.97347 ? 78  ILE B CA  1 
ATOM   2470 C  C   . ILE B 1 78  ? 13.33042  -4.58253  -18.93867 1.000 10.92356 ? 78  ILE B C   1 
ATOM   2471 O  O   . ILE B 1 78  ? 12.79130  -4.17304  -19.97258 1.000 11.64434 ? 78  ILE B O   1 
ATOM   2472 C  CB  . ILE B 1 78  ? 12.03346  -4.59809  -16.79512 1.000 11.60111 ? 78  ILE B CB  1 
ATOM   2473 C  CG1 . ILE B 1 78  ? 10.68031  -4.38351  -17.47401 1.000 11.36822 ? 78  ILE B CG1 1 
ATOM   2474 C  CG2 . ILE B 1 78  ? 11.94478  -4.00908  -15.37107 1.000 17.03205 ? 78  ILE B CG2 1 
ATOM   2475 C  CD1 . ILE B 1 78  ? 9.57266   -5.25754  -16.88480 1.000 15.84164 ? 78  ILE B CD1 1 
ATOM   2476 N  N   A ARG B 1 79  ? 14.07879  -5.68419  -18.90442 0.543 12.03846 ? 79  ARG B N   1 
ATOM   2477 N  N   B ARG B 1 79  ? 14.09383  -5.67044  -18.90244 0.457 12.05950 ? 79  ARG B N   1 
ATOM   2478 C  CA  A ARG B 1 79  ? 14.22021  -6.54117  -20.08062 0.543 12.23378 ? 79  ARG B CA  1 
ATOM   2479 C  CA  B ARG B 1 79  ? 14.20355  -6.56203  -20.05077 0.457 12.27465 ? 79  ARG B CA  1 
ATOM   2480 C  C   A ARG B 1 79  ? 13.00304  -7.44921  -20.19414 0.543 10.79943 ? 79  ARG B C   1 
ATOM   2481 C  C   B ARG B 1 79  ? 12.93437  -7.39049  -20.14987 0.457 10.80863 ? 79  ARG B C   1 
ATOM   2482 O  O   A ARG B 1 79  ? 12.75075  -8.27892  -19.31095 0.543 15.25632 ? 79  ARG B O   1 
ATOM   2483 O  O   B ARG B 1 79  ? 12.56802  -8.09283  -19.19923 0.457 14.93984 ? 79  ARG B O   1 
ATOM   2484 C  CB  A ARG B 1 79  ? 15.49758  -7.37517  -19.99728 0.543 15.10393 ? 79  ARG B CB  1 
ATOM   2485 C  CB  B ARG B 1 79  ? 15.42205  -7.46886  -19.91071 0.457 15.08010 ? 79  ARG B CB  1 
ATOM   2486 C  CG  A ARG B 1 79  ? 16.75280  -6.61105  -20.37616 0.543 16.56888 ? 79  ARG B CG  1 
ATOM   2487 C  CG  B ARG B 1 79  ? 16.70990  -6.69897  -19.85273 0.457 16.66517 ? 79  ARG B CG  1 
ATOM   2488 C  CD  A ARG B 1 79  ? 17.96342  -7.54472  -20.43398 0.543 19.14636 ? 79  ARG B CD  1 
ATOM   2489 C  CD  B ARG B 1 79  ? 17.91480  -7.62080  -19.87931 0.457 19.64880 ? 79  ARG B CD  1 
ATOM   2490 N  NE  A ARG B 1 79  ? 19.17632  -6.81898  -20.79389 0.543 22.45700 ? 79  ARG B NE  1 
ATOM   2491 N  NE  B ARG B 1 79  ? 19.06903  -6.88733  -20.37718 0.457 21.88169 ? 79  ARG B NE  1 
ATOM   2492 C  CZ  A ARG B 1 79  ? 19.99729  -6.24613  -19.92240 0.543 24.01685 ? 79  ARG B CZ  1 
ATOM   2493 C  CZ  B ARG B 1 79  ? 19.32288  -6.69824  -21.66374 0.457 20.75516 ? 79  ARG B CZ  1 
ATOM   2494 N  NH1 A ARG B 1 79  ? 19.77844  -6.30783  -18.61735 0.543 24.36394 ? 79  ARG B NH1 1 
ATOM   2495 N  NH1 B ARG B 1 79  ? 18.57071  -7.25140  -22.60551 0.457 20.72843 ? 79  ARG B NH1 1 
ATOM   2496 N  NH2 A ARG B 1 79  ? 21.06125  -5.58397  -20.36976 0.543 28.56204 ? 79  ARG B NH2 1 
ATOM   2497 N  NH2 B ARG B 1 79  ? 20.34707  -5.92599  -22.01502 0.457 25.43690 ? 79  ARG B NH2 1 
ATOM   2498 N  N   . ARG B 1 80  ? 12.25848  -7.30538  -21.29556 1.000 9.31247  ? 80  ARG B N   1 
ATOM   2499 C  CA  . ARG B 1 80  ? 11.03945  -8.06934  -21.52923 1.000 9.49634  ? 80  ARG B CA  1 
ATOM   2500 C  C   . ARG B 1 80  ? 11.29233  -9.12067  -22.60658 1.000 9.55653  ? 80  ARG B C   1 
ATOM   2501 O  O   . ARG B 1 80  ? 11.47320  -8.78655  -23.78747 1.000 10.53607 ? 80  ARG B O   1 
ATOM   2502 C  CB  . ARG B 1 80  ? 9.89888   -7.13396  -21.88330 1.000 9.10554  ? 80  ARG B CB  1 
ATOM   2503 C  CG  . ARG B 1 80  ? 9.49901   -6.29818  -20.64225 1.000 9.51111  ? 80  ARG B CG  1 
ATOM   2504 C  CD  . ARG B 1 80  ? 8.70811   -5.05236  -20.94358 1.000 11.31396 ? 80  ARG B CD  1 
ATOM   2505 N  NE  . ARG B 1 80  ? 7.46101   -5.36152  -21.62444 1.000 11.16225 ? 80  ARG B NE  1 
ATOM   2506 C  CZ  . ARG B 1 80  ? 6.62865   -4.44793  -22.11349 1.000 9.82959  ? 80  ARG B CZ  1 
ATOM   2507 N  NH1 . ARG B 1 80  ? 6.79495   -3.14977  -21.86891 1.000 9.25296  ? 80  ARG B NH1 1 
ATOM   2508 N  NH2 . ARG B 1 80  ? 5.61016   -4.84657  -22.88044 1.000 9.92986  ? 80  ARG B NH2 1 
ATOM   2509 N  N   . VAL B 1 81  ? 11.31434  -10.38005 -22.17982 1.000 11.19572 ? 81  VAL B N   1 
ATOM   2510 C  CA  . VAL B 1 81  ? 11.68528  -11.50527 -23.03516 1.000 11.66825 ? 81  VAL B CA  1 
ATOM   2511 C  C   . VAL B 1 81  ? 10.42586  -11.99197 -23.72960 1.000 9.78466  ? 81  VAL B C   1 
ATOM   2512 O  O   . VAL B 1 81  ? 9.55220   -12.59253 -23.10474 1.000 16.48507 ? 81  VAL B O   1 
ATOM   2513 C  CB  . VAL B 1 81  ? 12.30974  -12.63291 -22.21054 1.000 14.48826 ? 81  VAL B CB  1 
ATOM   2514 C  CG1 . VAL B 1 81  ? 12.66825  -13.84158 -23.12552 1.000 13.84609 ? 81  VAL B CG1 1 
ATOM   2515 C  CG2 . VAL B 1 81  ? 13.51975  -12.13421 -21.45377 1.000 13.43542 ? 81  VAL B CG2 1 
ATOM   2516 N  N   . TYR B 1 82  ? 10.33297  -11.73830 -25.02867 1.000 9.68217  ? 82  TYR B N   1 
ATOM   2517 C  CA  . TYR B 1 82  ? 9.20532   -12.16715 -25.83895 1.000 12.35984 ? 82  TYR B CA  1 
ATOM   2518 C  C   . TYR B 1 82  ? 9.67500   -13.12215 -26.92397 1.000 13.06592 ? 82  TYR B C   1 
ATOM   2519 O  O   . TYR B 1 82  ? 10.86409  -13.16147 -27.27212 1.000 18.77071 ? 82  TYR B O   1 
ATOM   2520 C  CB  . TYR B 1 82  ? 8.53514   -10.95706 -26.47510 1.000 9.75296  ? 82  TYR B CB  1 
ATOM   2521 C  CG  . TYR B 1 82  ? 7.84223   -10.08309 -25.45881 1.000 7.83186  ? 82  TYR B CG  1 
ATOM   2522 C  CD1 . TYR B 1 82  ? 6.90471   -10.62947 -24.58336 1.000 11.24574 ? 82  TYR B CD1 1 
ATOM   2523 C  CD2 . TYR B 1 82  ? 8.11078   -8.71926  -25.37920 1.000 10.41028 ? 82  TYR B CD2 1 
ATOM   2524 C  CE1 . TYR B 1 82  ? 6.24996   -9.83280  -23.60795 1.000 8.00628  ? 82  TYR B CE1 1 
ATOM   2525 C  CE2 . TYR B 1 82  ? 7.44778   -7.91262  -24.41467 1.000 8.21904  ? 82  TYR B CE2 1 
ATOM   2526 C  CZ  . TYR B 1 82  ? 6.52723   -8.48656  -23.56144 1.000 9.72373  ? 82  TYR B CZ  1 
ATOM   2527 O  OH  . TYR B 1 82  ? 5.91118   -7.72363  -22.60450 1.000 11.17687 ? 82  TYR B OH  1 
ATOM   2528 N  N   . GLU B 1 83  ? 8.74696   -13.87608 -27.44192 1.000 10.81523 ? 83  GLU B N   1 
ATOM   2529 C  CA  . GLU B 1 83  ? 9.12404   -14.69606 -28.58934 1.000 10.26443 ? 83  GLU B CA  1 
ATOM   2530 C  C   . GLU B 1 83  ? 8.91113   -13.94071 -29.90192 1.000 11.41217 ? 83  GLU B C   1 
ATOM   2531 O  O   . GLU B 1 83  ? 8.06512   -13.03024 -29.98216 1.000 9.62172  ? 83  GLU B O   1 
ATOM   2532 C  CB  . GLU B 1 83  ? 8.32197   -15.98087 -28.57398 1.000 12.45813 ? 83  GLU B CB  1 
ATOM   2533 C  CG  . GLU B 1 83  ? 8.69837   -16.77365 -27.33658 1.000 19.06715 ? 83  GLU B CG  1 
ATOM   2534 C  CD  . GLU B 1 83  ? 7.82358   -17.95786 -27.08768 1.000 33.87254 ? 83  GLU B CD  1 
ATOM   2535 O  OE1 . GLU B 1 83  ? 7.26343   -18.47328 -28.07267 1.000 28.95512 ? 83  GLU B OE1 1 
ATOM   2536 O  OE2 . GLU B 1 83  ? 7.69380   -18.36235 -25.90443 1.000 36.62726 ? 83  GLU B OE2 1 
ATOM   2537 N  N   . PRO B 1 84  ? 9.64064   -14.29759 -30.96229 1.000 9.17722  ? 84  PRO B N   1 
ATOM   2538 C  CA  . PRO B 1 84  ? 9.49783   -13.59076 -32.24886 1.000 8.59935  ? 84  PRO B CA  1 
ATOM   2539 C  C   . PRO B 1 84  ? 8.14349   -13.82724 -32.89881 1.000 9.87926  ? 84  PRO B C   1 
ATOM   2540 O  O   . PRO B 1 84  ? 7.48318   -14.85263 -32.71440 1.000 9.57399  ? 84  PRO B O   1 
ATOM   2541 C  CB  . PRO B 1 84  ? 10.61497  -14.18153 -33.12127 1.000 11.62202 ? 84  PRO B CB  1 
ATOM   2542 C  CG  . PRO B 1 84  ? 10.99894  -15.46194 -32.42631 1.000 21.33121 ? 84  PRO B CG  1 
ATOM   2543 C  CD  . PRO B 1 84  ? 10.73083  -15.29083 -30.97382 1.000 14.28519 ? 84  PRO B CD  1 
ATOM   2544 N  N   . ILE B 1 85  ? 7.75610   -12.86303 -33.72794 1.000 8.03363  ? 85  ILE B N   1 
ATOM   2545 C  CA  . ILE B 1 85  ? 6.56910   -13.01168 -34.55822 1.000 8.00569  ? 85  ILE B CA  1 
ATOM   2546 C  C   . ILE B 1 85  ? 6.82959   -14.07466 -35.62928 1.000 8.80533  ? 85  ILE B C   1 
ATOM   2547 O  O   . ILE B 1 85  ? 7.91953   -14.12924 -36.22403 1.000 12.67697 ? 85  ILE B O   1 
ATOM   2548 C  CB  . ILE B 1 85  ? 6.22651   -11.64753 -35.17405 1.000 9.67302  ? 85  ILE B CB  1 
ATOM   2549 C  CG1 . ILE B 1 85  ? 5.77646   -10.69205 -34.06030 1.000 7.22808  ? 85  ILE B CG1 1 
ATOM   2550 C  CG2 . ILE B 1 85  ? 5.10787   -11.76928 -36.21892 1.000 11.75526 ? 85  ILE B CG2 1 
ATOM   2551 C  CD1 . ILE B 1 85  ? 5.56485   -9.27038  -34.57061 1.000 11.00218 ? 85  ILE B CD1 1 
ATOM   2552 N  N   . GLU B 1 86  ? 5.84002   -14.93985 -35.84690 1.000 9.82985  ? 86  GLU B N   1 
ATOM   2553 C  CA  . GLU B 1 86  ? 5.95387   -16.03692 -36.82615 1.000 12.70172 ? 86  GLU B CA  1 
ATOM   2554 C  C   . GLU B 1 86  ? 5.59423   -15.57466 -38.23198 1.000 17.42124 ? 86  GLU B C   1 
ATOM   2555 O  O   . GLU B 1 86  ? 6.29881   -15.90483 -39.20261 1.000 20.00150 ? 86  GLU B O   1 
ATOM   2556 C  CB  . GLU B 1 86  ? 5.04757   -17.19429 -36.39490 1.000 15.61810 ? 86  GLU B CB  1 
ATOM   2557 C  CG  . GLU B 1 86  ? 5.31042   -17.66014 -34.94433 1.000 22.90368 ? 86  GLU B CG  1 
ATOM   2558 C  CD  . GLU B 1 86  ? 4.58867   -18.95664 -34.53210 1.000 34.42726 ? 86  GLU B CD  1 
ATOM   2559 O  OE1 . GLU B 1 86  ? 3.33745   -18.97488 -34.41345 1.000 20.45489 ? 86  GLU B OE1 1 
ATOM   2560 O  OE2 . GLU B 1 86  ? 5.29336   -19.96603 -34.28666 1.000 37.91719 ? 86  GLU B OE2 1 
ATOM   2561 N  N   . VAL B 1 87  ? 4.53309   -14.77798 -38.35902 1.000 9.43592  ? 87  VAL B N   1 
ATOM   2562 C  CA  . VAL B 1 87  ? 3.96538   -14.35331 -39.63252 1.000 11.23880 ? 87  VAL B CA  1 
ATOM   2563 C  C   . VAL B 1 87  ? 4.59356   -13.05234 -40.14629 1.000 11.21650 ? 87  VAL B C   1 
ATOM   2564 O  O   . VAL B 1 87  ? 5.45383   -12.45987 -39.48332 1.000 13.94070 ? 87  VAL B O   1 
ATOM   2565 C  CB  . VAL B 1 87  ? 2.44325   -14.19573 -39.50206 1.000 12.40176 ? 87  VAL B CB  1 
ATOM   2566 C  CG1 . VAL B 1 87  ? 1.80224   -15.52801 -39.05588 1.000 12.34715 ? 87  VAL B CG1 1 
ATOM   2567 C  CG2 . VAL B 1 87  ? 2.10734   -13.08801 -38.49905 1.000 12.84485 ? 87  VAL B CG2 1 
ATOM   2568 N  N   . ASP B 1 88  ? 4.19109   -12.62853 -41.35369 1.000 13.04613 ? 88  ASP B N   1 
ATOM   2569 C  CA  . ASP B 1 88  ? 4.81680   -11.50552 -42.06765 1.000 11.88231 ? 88  ASP B CA  1 
ATOM   2570 C  C   . ASP B 1 88  ? 3.83159   -10.34920 -42.10458 1.000 12.26381 ? 88  ASP B C   1 
ATOM   2571 O  O   . ASP B 1 88  ? 2.92479   -10.31677 -42.93581 1.000 12.41655 ? 88  ASP B O   1 
ATOM   2572 C  CB  . ASP B 1 88  ? 5.21142   -11.92373 -43.48512 1.000 13.25235 ? 88  ASP B CB  1 
ATOM   2573 C  CG  . ASP B 1 88  ? 5.80205   -10.80265 -44.27357 1.000 17.79944 ? 88  ASP B CG  1 
ATOM   2574 O  OD1 . ASP B 1 88  ? 6.13392   -9.75010  -43.68182 1.000 16.79162 ? 88  ASP B OD1 1 
ATOM   2575 O  OD2 . ASP B 1 88  ? 5.91035   -10.96422 -45.51174 1.000 22.51484 ? 88  ASP B OD2 1 
ATOM   2576 N  N   . PHE B 1 89  ? 4.03032   -9.38998  -41.21828 1.000 11.81464 ? 89  PHE B N   1 
ATOM   2577 C  CA  . PHE B 1 89  ? 3.20807   -8.19223  -41.21230 1.000 10.05834 ? 89  PHE B CA  1 
ATOM   2578 C  C   . PHE B 1 89  ? 3.67123   -7.11761  -42.17555 1.000 11.28080 ? 89  PHE B C   1 
ATOM   2579 O  O   . PHE B 1 89  ? 3.04213   -6.04891  -42.22875 1.000 10.96651 ? 89  PHE B O   1 
ATOM   2580 C  CB  . PHE B 1 89  ? 3.19601   -7.60710  -39.78970 1.000 9.74896  ? 89  PHE B CB  1 
ATOM   2581 C  CG  . PHE B 1 89  ? 2.29144   -8.36404  -38.85826 1.000 7.05528  ? 89  PHE B CG  1 
ATOM   2582 C  CD1 . PHE B 1 89  ? 0.88297   -8.25903  -39.00288 1.000 11.11496 ? 89  PHE B CD1 1 
ATOM   2583 C  CD2 . PHE B 1 89  ? 2.79977   -9.14016  -37.82547 1.000 7.28767  ? 89  PHE B CD2 1 
ATOM   2584 C  CE1 . PHE B 1 89  ? -0.01412  -8.93412  -38.14467 1.000 10.31274 ? 89  PHE B CE1 1 
ATOM   2585 C  CE2 . PHE B 1 89  ? 1.92752   -9.84457  -36.95909 1.000 8.72085  ? 89  PHE B CE2 1 
ATOM   2586 C  CZ  . PHE B 1 89  ? 0.51470   -9.75404  -37.10944 1.000 11.05955 ? 89  PHE B CZ  1 
ATOM   2587 N  N   . THR B 1 90  ? 4.74686   -7.35660  -42.92356 1.000 13.02457 ? 90  THR B N   1 
ATOM   2588 C  CA  . THR B 1 90  ? 5.28644   -6.22051  -43.64404 1.000 11.96884 ? 90  THR B CA  1 
ATOM   2589 C  C   . THR B 1 90  ? 4.39653   -5.73540  -44.79275 1.000 16.16048 ? 90  THR B C   1 
ATOM   2590 O  O   . THR B 1 90  ? 4.41863   -4.52894  -45.06346 1.000 15.93790 ? 90  THR B O   1 
ATOM   2591 C  CB  . THR B 1 90  ? 6.72721   -6.51147  -44.09750 1.000 17.24360 ? 90  THR B CB  1 
ATOM   2592 O  OG1 . THR B 1 90  ? 6.76386   -7.56965  -45.05615 1.000 18.12801 ? 90  THR B OG1 1 
ATOM   2593 C  CG2 . THR B 1 90  ? 7.59970   -6.88495  -42.88651 1.000 15.97514 ? 90  THR B CG2 1 
ATOM   2594 N  N   . PRO B 1 91  ? 3.55050   -6.55906  -45.43852 1.000 17.27863 ? 91  PRO B N   1 
ATOM   2595 C  CA  . PRO B 1 91  ? 2.56100   -5.96712  -46.36601 1.000 17.85208 ? 91  PRO B CA  1 
ATOM   2596 C  C   . PRO B 1 91  ? 1.62035   -4.99037  -45.69789 1.000 18.12077 ? 91  PRO B C   1 
ATOM   2597 O  O   . PRO B 1 91  ? 1.38210   -3.88745  -46.21217 1.000 17.44102 ? 91  PRO B O   1 
ATOM   2598 C  CB  . PRO B 1 91  ? 1.80309   -7.18775  -46.90292 1.000 19.41470 ? 91  PRO B CB  1 
ATOM   2599 C  CG  . PRO B 1 91  ? 2.76245   -8.29083  -46.80120 1.000 21.05437 ? 91  PRO B CG  1 
ATOM   2600 C  CD  . PRO B 1 91  ? 3.53576   -8.04018  -45.52100 1.000 16.19137 ? 91  PRO B CD  1 
ATOM   2601 N  N   . LEU B 1 92  ? 1.12696   -5.34972  -44.51679 1.000 16.00340 ? 92  LEU B N   1 
ATOM   2602 C  CA  . LEU B 1 92  ? 0.26626   -4.44831  -43.76867 1.000 19.55967 ? 92  LEU B CA  1 
ATOM   2603 C  C   . LEU B 1 92  ? 1.00159   -3.16073  -43.41707 1.000 15.11754 ? 92  LEU B C   1 
ATOM   2604 O  O   . LEU B 1 92  ? 0.44694   -2.06153  -43.53658 1.000 17.33960 ? 92  LEU B O   1 
ATOM   2605 C  CB  . LEU B 1 92  ? -0.22649  -5.17098  -42.50486 1.000 17.30367 ? 92  LEU B CB  1 
ATOM   2606 C  CG  . LEU B 1 92  ? -1.13787  -4.45240  -41.51983 1.000 22.92231 ? 92  LEU B CG  1 
ATOM   2607 C  CD1 . LEU B 1 92  ? -1.97487  -5.49499  -40.78219 1.000 24.46817 ? 92  LEU B CD1 1 
ATOM   2608 C  CD2 . LEU B 1 92  ? -0.33782  -3.63192  -40.51390 1.000 22.72482 ? 92  LEU B CD2 1 
ATOM   2609 N  N   . ILE B 1 93  ? 2.24783   -3.28008  -42.95785 1.000 12.64831 ? 93  ILE B N   1 
ATOM   2610 C  CA  . ILE B 1 93  ? 3.00829   -2.11181  -42.54035 1.000 11.76330 ? 93  ILE B CA  1 
ATOM   2611 C  C   . ILE B 1 93  ? 3.27669   -1.19240  -43.72342 1.000 14.81416 ? 93  ILE B C   1 
ATOM   2612 O  O   . ILE B 1 93  ? 3.33327   0.03755   -43.57473 1.000 17.81073 ? 93  ILE B O   1 
ATOM   2613 C  CB  . ILE B 1 93  ? 4.30657   -2.58185  -41.87045 1.000 13.63698 ? 93  ILE B CB  1 
ATOM   2614 C  CG1 . ILE B 1 93  ? 3.96822   -3.42483  -40.62840 1.000 13.40449 ? 93  ILE B CG1 1 
ATOM   2615 C  CG2 . ILE B 1 93  ? 5.19542   -1.40410  -41.52225 1.000 10.95944 ? 93  ILE B CG2 1 
ATOM   2616 C  CD1 . ILE B 1 93  ? 5.16615   -4.13272  -40.02784 1.000 11.55517 ? 93  ILE B CD1 1 
ATOM   2617 N  N   . SER B 1 94  ? 3.42021   -1.76142  -44.92340 1.000 16.04702 ? 94  SER B N   1 
ATOM   2618 C  CA  . SER B 1 94  ? 3.72116   -0.92332  -46.07691 1.000 12.79810 ? 94  SER B CA  1 
ATOM   2619 C  C   . SER B 1 94  ? 2.57329   0.02419   -46.40313 1.000 19.47321 ? 94  SER B C   1 
ATOM   2620 O  O   . SER B 1 94  ? 2.81877   1.10245   -46.95435 1.000 19.05043 ? 94  SER B O   1 
ATOM   2621 C  CB  . SER B 1 94  ? 4.05080   -1.79479  -47.28868 1.000 15.10478 ? 94  SER B CB  1 
ATOM   2622 O  OG  . SER B 1 94  ? 5.33549   -2.39546  -47.14467 1.000 17.93944 ? 94  SER B OG  1 
ATOM   2623 N  N   . GLU B 1 95  ? 1.32642   -0.36649  -46.09454 1.000 17.53708 ? 95  GLU B N   1 
ATOM   2624 C  CA  . GLU B 1 95  ? 0.16979   0.52926   -46.23392 1.000 17.28151 ? 95  GLU B CA  1 
ATOM   2625 C  C   . GLU B 1 95  ? 0.29922   1.73731   -45.33418 1.000 24.96192 ? 95  GLU B C   1 
ATOM   2626 O  O   . GLU B 1 95  ? -0.03246  2.86040   -45.73166 1.000 19.93588 ? 95  GLU B O   1 
ATOM   2627 C  CB  . GLU B 1 95  ? -1.11428  -0.20426  -45.86868 1.000 19.15789 ? 95  GLU B CB  1 
ATOM   2628 C  CG  . GLU B 1 95  ? -1.36679  -1.44578  -46.67189 1.000 25.15726 ? 95  GLU B CG  1 
ATOM   2629 C  CD  . GLU B 1 95  ? -2.00068  -1.14153  -48.02237 1.000 40.23063 ? 95  GLU B CD  1 
ATOM   2630 O  OE1 . GLU B 1 95  ? -3.22442  -0.86220  -48.06244 1.000 52.90354 ? 95  GLU B OE1 1 
ATOM   2631 O  OE2 . GLU B 1 95  ? -1.27135  -1.17762  -49.03789 1.000 38.24275 ? 95  GLU B OE2 1 
ATOM   2632 N  N   . GLY B 1 96  ? 0.71366   1.51699   -44.09032 1.000 16.20576 ? 96  GLY B N   1 
ATOM   2633 C  CA  . GLY B 1 96  ? 0.92534   2.64186   -43.18798 1.000 14.79996 ? 96  GLY B CA  1 
ATOM   2634 C  C   . GLY B 1 96  ? 2.06134   3.54665   -43.63248 1.000 18.89803 ? 96  GLY B C   1 
ATOM   2635 O  O   . GLY B 1 96  ? 1.94800   4.77446   -43.54829 1.000 20.03637 ? 96  GLY B O   1 
ATOM   2636 N  N   . ILE B 1 97  ? 3.16982   2.95602   -44.10221 1.000 15.24331 ? 97  ILE B N   1 
ATOM   2637 C  CA  . ILE B 1 97  ? 4.31149   3.72551   -44.58951 1.000 19.36859 ? 97  ILE B CA  1 
ATOM   2638 C  C   . ILE B 1 97  ? 3.87613   4.64508   -45.71681 1.000 21.23429 ? 97  ILE B C   1 
ATOM   2639 O  O   . ILE B 1 97  ? 4.29936   5.81164   -45.79254 1.000 20.91473 ? 97  ILE B O   1 
ATOM   2640 C  CB  . ILE B 1 97  ? 5.41279   2.77979   -45.08230 1.000 20.56536 ? 97  ILE B CB  1 
ATOM   2641 C  CG1 . ILE B 1 97  ? 6.02636   2.00280   -43.91910 1.000 17.22393 ? 97  ILE B CG1 1 
ATOM   2642 C  CG2 . ILE B 1 97  ? 6.47092   3.56269   -45.85515 1.000 19.73626 ? 97  ILE B CG2 1 
ATOM   2643 C  CD1 . ILE B 1 97  ? 6.97965   0.94111   -44.40737 1.000 20.44746 ? 97  ILE B CD1 1 
ATOM   2644 N  N   . ARG B 1 98  ? 3.07038   4.10463   -46.63205 1.000 22.13625 ? 98  ARG B N   1 
ATOM   2645 C  CA  . ARG B 1 98  ? 2.60363   4.86281   -47.78541 1.000 24.27290 ? 98  ARG B CA  1 
ATOM   2646 C  C   . ARG B 1 98  ? 1.82332   6.07468   -47.33660 1.000 20.48859 ? 98  ARG B C   1 
ATOM   2647 O  O   . ARG B 1 98  ? 2.02965   7.18183   -47.85437 1.000 24.93012 ? 98  ARG B O   1 
ATOM   2648 C  CB  . ARG B 1 98  ? 1.75586   3.95517   -48.68027 1.000 24.62507 ? 98  ARG B CB  1 
ATOM   2649 C  CG  . ARG B 1 98  ? 0.82779   4.61945   -49.70041 1.000 34.10442 ? 98  ARG B CG  1 
ATOM   2650 C  CD  . ARG B 1 98  ? -0.14505  3.58803   -50.32305 1.000 37.36566 ? 98  ARG B CD  1 
ATOM   2651 N  NE  . ARG B 1 98  ? 0.25216   2.19270   -50.10566 1.000 44.30686 ? 98  ARG B NE  1 
ATOM   2652 C  CZ  . ARG B 1 98  ? 1.25391   1.58284   -50.73314 1.000 48.02726 ? 98  ARG B CZ  1 
ATOM   2653 N  NH1 . ARG B 1 98  ? 1.99373   2.21772   -51.63011 1.000 50.50129 ? 98  ARG B NH1 1 
ATOM   2654 N  NH2 . ARG B 1 98  ? 1.53258   0.31102   -50.43850 1.000 43.19175 ? 98  ARG B NH2 1 
ATOM   2655 N  N   . GLU B 1 99  ? 0.99152   5.90908   -46.29823 1.000 18.50204 ? 99  GLU B N   1 
ATOM   2656 C  CA  . GLU B 1 99  ? 0.21776   7.01405   -45.77256 1.000 21.59042 ? 99  GLU B CA  1 
ATOM   2657 C  C   . GLU B 1 99  ? 1.05539   7.96439   -44.92005 1.000 24.28230 ? 99  GLU B C   1 
ATOM   2658 O  O   . GLU B 1 99  ? 0.75610   9.16656   -44.86898 1.000 26.12521 ? 99  GLU B O   1 
ATOM   2659 C  CB  . GLU B 1 99  ? -0.96550  6.45576   -44.98245 1.000 26.78849 ? 99  GLU B CB  1 
ATOM   2660 C  CG  . GLU B 1 99  ? -1.99671  7.49011   -44.63214 1.000 30.68797 ? 99  GLU B CG  1 
ATOM   2661 C  CD  . GLU B 1 99  ? -2.82920  7.89029   -45.82033 1.000 40.28726 ? 99  GLU B CD  1 
ATOM   2662 O  OE1 . GLU B 1 99  ? -2.87328  7.10552   -46.79491 1.000 43.36024 ? 99  GLU B OE1 1 
ATOM   2663 O  OE2 . GLU B 1 99  ? -3.43482  8.98545   -45.78115 1.000 42.99726 ? 99  GLU B OE2 1 
ATOM   2664 N  N   . LEU B 1 100 ? 2.11794   7.46535   -44.26475 1.000 16.27659 ? 100 LEU B N   1 
ATOM   2665 C  CA  . LEU B 1 100 ? 2.97193   8.35100   -43.47926 1.000 17.67592 ? 100 LEU B CA  1 
ATOM   2666 C  C   . LEU B 1 100 ? 3.85580   9.21940   -44.36394 1.000 20.76984 ? 100 LEU B C   1 
ATOM   2667 O  O   . LEU B 1 100 ? 4.19893   10.33686  -43.97270 1.000 26.92468 ? 100 LEU B O   1 
ATOM   2668 C  CB  . LEU B 1 100 ? 3.85585   7.55193   -42.52941 1.000 20.52805 ? 100 LEU B CB  1 
ATOM   2669 C  CG  . LEU B 1 100 ? 3.22131   6.95787   -41.28007 1.000 16.15349 ? 100 LEU B CG  1 
ATOM   2670 C  CD1 . LEU B 1 100 ? 4.24095   6.00490   -40.62581 1.000 18.17421 ? 100 LEU B CD1 1 
ATOM   2671 C  CD2 . LEU B 1 100 ? 2.72001   8.03701   -40.31043 1.000 19.05529 ? 100 LEU B CD2 1 
ATOM   2672 N  N   . GLY B 1 101 ? 4.23353   8.71755   -45.54199 1.000 24.13946 ? 101 GLY B N   1 
ATOM   2673 C  CA  . GLY B 1 101 ? 5.21442   9.39558   -46.37084 1.000 23.97560 ? 101 GLY B CA  1 
ATOM   2674 C  C   . GLY B 1 101 ? 6.53018   9.50545   -45.62616 1.000 27.84833 ? 101 GLY B C   1 
ATOM   2675 O  O   . GLY B 1 101 ? 7.09250   10.59750  -45.51864 1.000 27.55347 ? 101 GLY B O   1 
ATOM   2676 N  N   . LEU B 1 102 ? 7.01355   8.37898   -45.09090 1.000 24.90484 ? 102 LEU B N   1 
ATOM   2677 C  CA  . LEU B 1 102 ? 8.24858   8.36937   -44.31944 1.000 24.41856 ? 102 LEU B CA  1 
ATOM   2678 C  C   . LEU B 1 102 ? 9.40613   8.97696   -45.09898 1.000 21.87329 ? 102 LEU B C   1 
ATOM   2679 O  O   . LEU B 1 102 ? 9.59785   8.69198   -46.28610 1.000 27.55463 ? 102 LEU B O   1 
ATOM   2680 C  CB  . LEU B 1 102 ? 8.63401   6.94925   -43.94722 1.000 21.27664 ? 102 LEU B CB  1 
ATOM   2681 C  CG  . LEU B 1 102 ? 7.99426   6.23083   -42.78312 1.000 22.13734 ? 102 LEU B CG  1 
ATOM   2682 C  CD1 . LEU B 1 102 ? 8.69747   4.91659   -42.73061 1.000 18.68089 ? 102 LEU B CD1 1 
ATOM   2683 C  CD2 . LEU B 1 102 ? 8.12340   7.00763   -41.46036 1.000 18.37308 ? 102 LEU B CD2 1 
ATOM   2684 N  N   . ASP B 1 103 ? 10.19797  9.77090   -44.39627 1.000 18.89213 ? 103 ASP B N   1 
ATOM   2685 C  CA  . ASP B 1 103 ? 11.38542  10.40706  -44.96186 1.000 20.18477 ? 103 ASP B CA  1 
ATOM   2686 C  C   . ASP B 1 103 ? 12.29643  9.35191   -45.57245 1.000 22.92634 ? 103 ASP B C   1 
ATOM   2687 O  O   . ASP B 1 103 ? 12.84204  8.50552   -44.86324 1.000 22.85264 ? 103 ASP B O   1 
ATOM   2688 C  CB  . ASP B 1 103 ? 12.10794  11.18102  -43.86222 1.000 27.22391 ? 103 ASP B CB  1 
ATOM   2689 C  CG  . ASP B 1 103 ? 13.26211  12.03118  -44.37365 1.000 27.66702 ? 103 ASP B CG  1 
ATOM   2690 O  OD1 . ASP B 1 103 ? 13.57879  11.97357  -45.58159 1.000 28.36265 ? 103 ASP B OD1 1 
ATOM   2691 O  OD2 . ASP B 1 103 ? 13.83956  12.77108  -43.54949 1.000 30.05498 ? 103 ASP B OD2 1 
ATOM   2692 N  N   . ARG B 1 104 ? 12.47236  9.40995   -46.89116 1.000 22.31362 ? 104 ARG B N   1 
ATOM   2693 C  CA  . ARG B 1 104 ? 13.34406  8.45696   -47.57458 1.000 30.07584 ? 104 ARG B CA  1 
ATOM   2694 C  C   . ARG B 1 104 ? 14.83266  8.79724   -47.46345 1.000 19.91392 ? 104 ARG B C   1 
ATOM   2695 O  O   . ARG B 1 104 ? 15.66805  7.99371   -47.90983 1.000 26.60593 ? 104 ARG B O   1 
ATOM   2696 C  CB  . ARG B 1 104 ? 12.94345  8.34820   -49.05184 1.000 25.88516 ? 104 ARG B CB  1 
ATOM   2697 C  CG  . ARG B 1 104 ? 11.53927  7.83255   -49.27672 1.000 29.39917 ? 104 ARG B CG  1 
ATOM   2698 C  CD  . ARG B 1 104 ? 11.24548  7.65660   -50.74789 1.000 36.12048 ? 104 ARG B CD  1 
ATOM   2699 N  NE  . ARG B 1 104 ? 12.30695  6.88583   -51.38119 1.000 37.35779 ? 104 ARG B NE  1 
ATOM   2700 C  CZ  . ARG B 1 104 ? 12.24446  5.58766   -51.64538 1.000 42.52293 ? 104 ARG B CZ  1 
ATOM   2701 N  NH1 . ARG B 1 104 ? 11.15492  4.88010   -51.38918 1.000 41.88061 ? 104 ARG B NH1 1 
ATOM   2702 N  NH2 . ARG B 1 104 ? 13.30280  4.98446   -52.18251 1.000 41.86244 ? 104 ARG B NH2 1 
ATOM   2703 N  N   . SER B 1 105 ? 15.20055  9.91855   -46.85819 1.000 23.45045 ? 105 SER B N   1 
ATOM   2704 C  CA  . SER B 1 105 ? 16.60029  10.34668  -46.83050 1.000 25.28922 ? 105 SER B CA  1 
ATOM   2705 C  C   . SER B 1 105 ? 17.44524  9.61420   -45.79307 1.000 27.91453 ? 105 SER B C   1 
ATOM   2706 O  O   . SER B 1 105 ? 18.64823  9.88265   -45.69048 1.000 25.23195 ? 105 SER B O   1 
ATOM   2707 C  CB  . SER B 1 105 ? 16.69340  11.85539  -46.57942 1.000 30.99640 ? 105 SER B CB  1 
ATOM   2708 O  OG  . SER B 1 105 ? 16.41957  12.16333  -45.22099 1.000 38.03222 ? 105 SER B OG  1 
ATOM   2709 N  N   . GLU B 1 106 ? 16.87101  8.69485   -45.02746 1.000 21.26851 ? 106 GLU B N   1 
ATOM   2710 C  CA  . GLU B 1 106 ? 17.65513  7.91060   -44.08700 1.000 16.84928 ? 106 GLU B CA  1 
ATOM   2711 C  C   . GLU B 1 106 ? 16.86343  6.65939   -43.73590 1.000 18.94092 ? 106 GLU B C   1 
ATOM   2712 O  O   . GLU B 1 106 ? 15.63819  6.61176   -43.94668 1.000 16.93529 ? 106 GLU B O   1 
ATOM   2713 C  CB  . GLU B 1 106 ? 18.00240  8.71602   -42.82457 1.000 18.93726 ? 106 GLU B CB  1 
ATOM   2714 C  CG  . GLU B 1 106 ? 16.82138  8.99932   -41.89507 1.000 17.66077 ? 106 GLU B CG  1 
ATOM   2715 C  CD  . GLU B 1 106 ? 17.20416  9.97935   -40.81276 1.000 18.00991 ? 106 GLU B CD  1 
ATOM   2716 O  OE1 . GLU B 1 106 ? 17.98689  9.61358   -39.89987 1.000 23.27712 ? 106 GLU B OE1 1 
ATOM   2717 O  OE2 . GLU B 1 106 ? 16.74885  11.15729  -40.88914 1.000 24.65417 ? 106 GLU B OE2 1 
ATOM   2718 N  N   . PRO B 1 107 ? 17.52557  5.60912   -43.27213 1.000 14.59810 ? 107 PRO B N   1 
ATOM   2719 C  CA  . PRO B 1 107 ? 16.80594  4.38457   -42.92127 1.000 13.40432 ? 107 PRO B CA  1 
ATOM   2720 C  C   . PRO B 1 107 ? 16.08894  4.51875   -41.57820 1.000 10.93826 ? 107 PRO B C   1 
ATOM   2721 O  O   . PRO B 1 107 ? 16.35294  5.41798   -40.77286 1.000 12.73844 ? 107 PRO B O   1 
ATOM   2722 C  CB  . PRO B 1 107 ? 17.91085  3.32409   -42.86959 1.000 15.08250 ? 107 PRO B CB  1 
ATOM   2723 C  CG  . PRO B 1 107 ? 19.16891  4.10666   -42.56046 1.000 14.68158 ? 107 PRO B CG  1 
ATOM   2724 C  CD  . PRO B 1 107 ? 19.00180  5.43518   -43.24569 1.000 14.39025 ? 107 PRO B CD  1 
ATOM   2725 N  N   . TRP B 1 108 ? 15.12816  3.61398   -41.39120 1.000 13.11363 ? 108 TRP B N   1 
ATOM   2726 C  CA  . TRP B 1 108 ? 14.24104  3.59070   -40.23686 1.000 13.00002 ? 108 TRP B CA  1 
ATOM   2727 C  C   . TRP B 1 108 ? 14.35093  2.24462   -39.53936 1.000 12.43817 ? 108 TRP B C   1 
ATOM   2728 O  O   . TRP B 1 108 ? 14.87408  1.26598   -40.08122 1.000 13.11677 ? 108 TRP B O   1 
ATOM   2729 C  CB  . TRP B 1 108 ? 12.79281  3.85874   -40.66004 1.000 10.80890 ? 108 TRP B CB  1 
ATOM   2730 C  CG  . TRP B 1 108 ? 12.56116  5.26791   -41.09415 1.000 13.66554 ? 108 TRP B CG  1 
ATOM   2731 C  CD1 . TRP B 1 108 ? 12.95657  5.83907   -42.29408 1.000 14.55272 ? 108 TRP B CD1 1 
ATOM   2732 C  CD2 . TRP B 1 108 ? 11.87380  6.30593   -40.37295 1.000 12.32307 ? 108 TRP B CD2 1 
ATOM   2733 N  NE1 . TRP B 1 108 ? 12.56563  7.15078   -42.33850 1.000 14.33642 ? 108 TRP B NE1 1 
ATOM   2734 C  CE2 . TRP B 1 108 ? 11.90031  7.46929   -41.18328 1.000 13.97581 ? 108 TRP B CE2 1 
ATOM   2735 C  CE3 . TRP B 1 108 ? 11.22220  6.36496   -39.12674 1.000 12.54154 ? 108 TRP B CE3 1 
ATOM   2736 C  CZ2 . TRP B 1 108 ? 11.34240  8.67706   -40.77641 1.000 14.08850 ? 108 TRP B CZ2 1 
ATOM   2737 C  CZ3 . TRP B 1 108 ? 10.65317  7.55295   -38.73809 1.000 12.35599 ? 108 TRP B CZ3 1 
ATOM   2738 C  CH2 . TRP B 1 108 ? 10.71882  8.70311   -39.54856 1.000 17.03167 ? 108 TRP B CH2 1 
ATOM   2739 N  N   . GLN B 1 109 ? 13.84372  2.20154   -38.30130 1.000 10.18060 ? 109 GLN B N   1 
ATOM   2740 C  CA  . GLN B 1 109 ? 13.85388  0.98342   -37.49901 1.000 9.39530  ? 109 GLN B CA  1 
ATOM   2741 C  C   . GLN B 1 109 ? 12.47169  0.84481   -36.87486 1.000 8.13490  ? 109 GLN B C   1 
ATOM   2742 O  O   . GLN B 1 109 ? 11.94138  1.82865   -36.35955 1.000 11.12851 ? 109 GLN B O   1 
ATOM   2743 C  CB  . GLN B 1 109 ? 14.90534  1.05775   -36.39493 1.000 9.81435  ? 109 GLN B CB  1 
ATOM   2744 C  CG  . GLN B 1 109 ? 14.98240  -0.19831  -35.54764 1.000 10.61017 ? 109 GLN B CG  1 
ATOM   2745 C  CD  . GLN B 1 109 ? 14.08731  -0.13558  -34.30607 1.000 10.29121 ? 109 GLN B CD  1 
ATOM   2746 O  OE1 . GLN B 1 109 ? 14.07109  0.88285   -33.61186 1.000 12.26312 ? 109 GLN B OE1 1 
ATOM   2747 N  NE2 . GLN B 1 109 ? 13.36788  -1.23054  -34.01646 1.000 10.45632 ? 109 GLN B NE2 1 
ATOM   2748 N  N   . ILE B 1 110 ? 11.86635  -0.32730  -36.97627 1.000 7.08971  ? 110 ILE B N   1 
ATOM   2749 C  CA  . ILE B 1 110 ? 10.52940  -0.50873  -36.41416 1.000 8.65129  ? 110 ILE B CA  1 
ATOM   2750 C  C   . ILE B 1 110 ? 10.50599  -1.61167  -35.36385 1.000 9.04094  ? 110 ILE B C   1 
ATOM   2751 O  O   . ILE B 1 110 ? 11.15457  -2.65927  -35.48314 1.000 9.04858  ? 110 ILE B O   1 
ATOM   2752 C  CB  . ILE B 1 110 ? 9.46125   -0.81333  -37.48135 1.000 9.95280  ? 110 ILE B CB  1 
ATOM   2753 C  CG1 . ILE B 1 110 ? 9.83003   -2.03728  -38.33565 1.000 9.19445  ? 110 ILE B CG1 1 
ATOM   2754 C  CG2 . ILE B 1 110 ? 9.26457   0.42855   -38.35322 1.000 11.18246 ? 110 ILE B CG2 1 
ATOM   2755 C  CD1 . ILE B 1 110 ? 8.65244   -2.50858  -39.26622 1.000 9.46172  ? 110 ILE B CD1 1 
ATOM   2756 N  N   . ASN B 1 111 ? 9.71294   -1.36115  -34.32807 1.000 7.87304  ? 111 ASN B N   1 
ATOM   2757 C  CA  . ASN B 1 111 ? 9.31013   -2.34210  -33.33494 1.000 7.87606  ? 111 ASN B CA  1 
ATOM   2758 C  C   . ASN B 1 111 ? 7.92375   -2.82261  -33.72909 1.000 7.11328  ? 111 ASN B C   1 
ATOM   2759 O  O   . ASN B 1 111 ? 7.04506   -2.00470  -33.98975 1.000 8.25536  ? 111 ASN B O   1 
ATOM   2760 C  CB  . ASN B 1 111 ? 9.21200   -1.70290  -31.94818 1.000 7.46158  ? 111 ASN B CB  1 
ATOM   2761 C  CG  . ASN B 1 111 ? 10.56018  -1.48060  -31.30461 1.000 10.41092 ? 111 ASN B CG  1 
ATOM   2762 O  OD1 . ASN B 1 111 ? 11.57845  -1.85610  -31.85479 1.000 10.12897 ? 111 ASN B OD1 1 
ATOM   2763 N  ND2 . ASN B 1 111 ? 10.55615  -0.89860  -30.09998 1.000 11.07368 ? 111 ASN B ND2 1 
ATOM   2764 N  N   . VAL B 1 112 ? 7.72304   -4.12769  -33.78053 1.000 4.87926  ? 112 VAL B N   1 
ATOM   2765 C  CA  . VAL B 1 112 ? 6.44125   -4.70330  -34.16528 1.000 5.59928  ? 112 VAL B CA  1 
ATOM   2766 C  C   . VAL B 1 112 ? 5.94648   -5.57616  -33.01820 1.000 7.10993  ? 112 VAL B C   1 
ATOM   2767 O  O   . VAL B 1 112 ? 6.61914   -6.54726  -32.61944 1.000 5.27719  ? 112 VAL B O   1 
ATOM   2768 C  CB  . VAL B 1 112 ? 6.53803   -5.51577  -35.47251 1.000 6.35579  ? 112 VAL B CB  1 
ATOM   2769 C  CG1 . VAL B 1 112 ? 5.15140   -6.04391  -35.88359 1.000 8.03375  ? 112 VAL B CG1 1 
ATOM   2770 C  CG2 . VAL B 1 112 ? 7.11563   -4.64520  -36.59779 1.000 9.46968  ? 112 VAL B CG2 1 
ATOM   2771 N  N   . HIS B 1 113 ? 4.77139   -5.22699  -32.47849 1.000 5.11830  ? 113 HIS B N   1 
ATOM   2772 C  CA  . HIS B 1 113 ? 4.16129   -5.94781  -31.35612 1.000 5.94608  ? 113 HIS B CA  1 
ATOM   2773 C  C   . HIS B 1 113 ? 2.87978   -6.60306  -31.82252 1.000 7.23112  ? 113 HIS B C   1 
ATOM   2774 O  O   . HIS B 1 113 ? 1.91894   -5.90697  -32.18444 1.000 6.05145  ? 113 HIS B O   1 
ATOM   2775 C  CB  . HIS B 1 113 ? 3.82404   -4.98363  -30.21463 1.000 5.32984  ? 113 HIS B CB  1 
ATOM   2776 C  CG  . HIS B 1 113 ? 5.00186   -4.23168  -29.68258 1.000 9.27442  ? 113 HIS B CG  1 
ATOM   2777 N  ND1 . HIS B 1 113 ? 5.57264   -4.53205  -28.46677 1.000 13.14487 ? 113 HIS B ND1 1 
ATOM   2778 C  CD2 . HIS B 1 113 ? 5.67218   -3.16955  -30.16660 1.000 9.07607  ? 113 HIS B CD2 1 
ATOM   2779 C  CE1 . HIS B 1 113 ? 6.56867   -3.69359  -28.23527 1.000 12.73352 ? 113 HIS B CE1 1 
ATOM   2780 N  NE2 . HIS B 1 113 ? 6.66368   -2.87029  -29.25915 1.000 12.24447 ? 113 HIS B NE2 1 
ATOM   2781 N  N   . GLN B 1 114 ? 2.83023   -7.92616  -31.80667 1.000 3.90750  ? 114 GLN B N   1 
ATOM   2782 C  CA  . GLN B 1 114 ? 1.60752   -8.63865  -32.16615 1.000 4.47984  ? 114 GLN B CA  1 
ATOM   2783 C  C   . GLN B 1 114 ? 0.92215   -8.96270  -30.83802 1.000 5.30089  ? 114 GLN B C   1 
ATOM   2784 O  O   . GLN B 1 114 ? 1.41143   -9.78583  -30.06991 1.000 7.13578  ? 114 GLN B O   1 
ATOM   2785 C  CB  . GLN B 1 114 ? 1.94195   -9.89520  -32.96567 1.000 5.45263  ? 114 GLN B CB  1 
ATOM   2786 C  CG  . GLN B 1 114 ? 0.74476   -10.74743 -33.24118 1.000 6.02527  ? 114 GLN B CG  1 
ATOM   2787 C  CD  . GLN B 1 114 ? 1.05898   -11.97656 -34.06155 1.000 7.75834  ? 114 GLN B CD  1 
ATOM   2788 O  OE1 . GLN B 1 114 ? 2.21721   -12.33868 -34.25282 1.000 9.75265  ? 114 GLN B OE1 1 
ATOM   2789 N  NE2 . GLN B 1 114 ? 0.01338   -12.67276 -34.48387 1.000 8.04505  ? 114 GLN B NE2 1 
ATOM   2790 N  N   . ASN B 1 115 ? -0.21658  -8.33259  -30.58269 1.000 2.84143  ? 115 ASN B N   1 
ATOM   2791 C  CA  . ASN B 1 115 ? -0.89547  -8.41279  -29.28786 1.000 4.31724  ? 115 ASN B CA  1 
ATOM   2792 C  C   . ASN B 1 115 ? -2.30403  -8.96782  -29.42753 1.000 5.84117  ? 115 ASN B C   1 
ATOM   2793 O  O   . ASN B 1 115 ? -3.06218  -8.58355  -30.33328 1.000 5.09252  ? 115 ASN B O   1 
ATOM   2794 C  CB  . ASN B 1 115 ? -1.07903  -7.03233  -28.61715 1.000 5.43993  ? 115 ASN B CB  1 
ATOM   2795 C  CG  . ASN B 1 115 ? 0.17244   -6.45438  -28.01331 1.000 10.98374 ? 115 ASN B CG  1 
ATOM   2796 O  OD1 . ASN B 1 115 ? 1.31645   -6.80567  -28.34651 1.000 11.58465 ? 115 ASN B OD1 1 
ATOM   2797 N  ND2 . ASN B 1 115 ? -0.04788  -5.49270  -27.10650 1.000 14.90155 ? 115 ASN B ND2 1 
ATOM   2798 N  N   . ARG B 1 116 ? -2.66645  -9.85166  -28.50633 1.000 4.38811  ? 116 ARG B N   1 
ATOM   2799 C  CA  . ARG B 1 116 ? -4.05992  -10.22355 -28.23424 1.000 4.72239  ? 116 ARG B CA  1 
ATOM   2800 C  C   . ARG B 1 116 ? -4.37782  -9.81465  -26.81253 1.000 6.36659  ? 116 ARG B C   1 
ATOM   2801 O  O   . ARG B 1 116 ? -3.62146  -10.14888 -25.89443 1.000 7.71835  ? 116 ARG B O   1 
ATOM   2802 C  CB  . ARG B 1 116 ? -4.29821  -11.73938 -28.37780 1.000 9.15666  ? 116 ARG B CB  1 
ATOM   2803 C  CG  . ARG B 1 116 ? -5.60124  -12.17955 -27.72975 1.000 11.09932 ? 116 ARG B CG  1 
ATOM   2804 C  CD  . ARG B 1 116 ? -5.91722  -13.64826 -28.04326 1.000 8.48439  ? 116 ARG B CD  1 
ATOM   2805 N  NE  . ARG B 1 116 ? -6.22981  -13.78795 -29.46449 1.000 9.00509  ? 116 ARG B NE  1 
ATOM   2806 C  CZ  . ARG B 1 116 ? -6.53095  -14.95024 -30.03161 1.000 11.25191 ? 116 ARG B CZ  1 
ATOM   2807 N  NH1 . ARG B 1 116 ? -6.42128  -16.08821 -29.35412 1.000 11.59813 ? 116 ARG B NH1 1 
ATOM   2808 N  NH2 . ARG B 1 116 ? -6.94368  -14.96706 -31.29809 1.000 10.21228 ? 116 ARG B NH2 1 
ATOM   2809 N  N   . THR B 1 117 ? -5.49498  -9.10381  -26.61355 1.000 4.45055  ? 117 THR B N   1 
ATOM   2810 C  CA  . THR B 1 117 ? -6.03460  -8.85962  -25.28288 1.000 4.63646  ? 117 THR B CA  1 
ATOM   2811 C  C   . THR B 1 117 ? -7.36811  -9.55887  -25.15578 1.000 6.75405  ? 117 THR B C   1 
ATOM   2812 O  O   . THR B 1 117 ? -8.22866  -9.44068  -26.04163 1.000 7.82352  ? 117 THR B O   1 
ATOM   2813 C  CB  . THR B 1 117 ? -6.16571  -7.36217  -25.01606 1.000 7.62209  ? 117 THR B CB  1 
ATOM   2814 O  OG1 . THR B 1 117 ? -4.84669  -6.82792  -24.84885 1.000 8.36624  ? 117 THR B OG1 1 
ATOM   2815 C  CG2 . THR B 1 117 ? -6.99610  -7.07712  -23.76007 1.000 7.52180  ? 117 THR B CG2 1 
ATOM   2816 N  N   A ARG B 1 118 ? -7.52829  -10.28990 -24.06372 0.426 5.79174  ? 118 ARG B N   1 
ATOM   2817 N  N   B ARG B 1 118 ? -7.53137  -10.30227 -24.06256 0.574 5.75355  ? 118 ARG B N   1 
ATOM   2818 C  CA  A ARG B 1 118 ? -8.75562  -10.99633 -23.75430 0.426 7.21257  ? 118 ARG B CA  1 
ATOM   2819 C  CA  B ARG B 1 118 ? -8.73338  -11.06972 -23.75739 0.574 7.17753  ? 118 ARG B CA  1 
ATOM   2820 C  C   A ARG B 1 118 ? -9.62212  -10.19577 -22.78892 0.426 7.22653  ? 118 ARG B C   1 
ATOM   2821 C  C   B ARG B 1 118 ? -9.59491  -10.36297 -22.71217 0.574 7.31263  ? 118 ARG B C   1 
ATOM   2822 O  O   A ARG B 1 118 ? -9.13996  -9.43815  -21.93842 0.426 8.48197  ? 118 ARG B O   1 
ATOM   2823 O  O   B ARG B 1 118 ? -9.07817  -9.85030  -21.70527 0.574 8.52449  ? 118 ARG B O   1 
ATOM   2824 C  CB  A ARG B 1 118 ? -8.44070  -12.36836 -23.16617 0.426 9.30768  ? 118 ARG B CB  1 
ATOM   2825 C  CB  B ARG B 1 118 ? -8.34586  -12.44819 -23.23462 0.574 9.25693  ? 118 ARG B CB  1 
ATOM   2826 C  CG  A ARG B 1 118 ? -7.97972  -13.33637 -24.21969 0.426 9.66985  ? 118 ARG B CG  1 
ATOM   2827 C  CG  B ARG B 1 118 ? -7.66469  -13.32250 -24.25089 0.574 9.94579  ? 118 ARG B CG  1 
ATOM   2828 C  CD  A ARG B 1 118 ? -8.18739  -14.78803 -23.79763 0.426 13.17163 ? 118 ARG B CD  1 
ATOM   2829 C  CD  B ARG B 1 118 ? -7.65306  -14.76857 -23.75311 0.574 12.40896 ? 118 ARG B CD  1 
ATOM   2830 N  NE  A ARG B 1 118 ? -8.22370  -15.64335 -24.97753 0.426 15.87588 ? 118 ARG B NE  1 
ATOM   2831 N  NE  B ARG B 1 118 ? -7.18810  -15.71332 -24.76491 0.574 15.99709 ? 118 ARG B NE  1 
ATOM   2832 C  CZ  A ARG B 1 118 ? -9.30948  -15.88358 -25.69990 0.426 15.63754 ? 118 ARG B CZ  1 
ATOM   2833 C  CZ  B ARG B 1 118 ? -7.86090  -16.06805 -25.85478 0.574 18.08141 ? 118 ARG B CZ  1 
ATOM   2834 N  NH1 A ARG B 1 118 ? -10.49426 -15.40721 -25.34913 0.426 17.63455 ? 118 ARG B NH1 1 
ATOM   2835 N  NH1 B ARG B 1 118 ? -9.01654  -15.50997 -26.17249 0.574 15.81412 ? 118 ARG B NH1 1 
ATOM   2836 N  NH2 A ARG B 1 118 ? -9.20294  -16.61201 -26.80708 0.426 17.96979 ? 118 ARG B NH2 1 
ATOM   2837 N  NH2 B ARG B 1 118 ? -7.36014  -17.01168 -26.64634 0.574 18.41671 ? 118 ARG B NH2 1 
ATOM   2838 N  N   . ALA B 1 119 ? -10.91196 -10.38716 -22.91903 1.000 6.53579  ? 119 ALA B N   1 
ATOM   2839 C  CA  . ALA B 1 119 ? -11.88729 -9.87332  -21.95844 1.000 8.28525  ? 119 ALA B CA  1 
ATOM   2840 C  C   . ALA B 1 119 ? -12.80443 -11.02437 -21.57590 1.000 9.72553  ? 119 ALA B C   1 
ATOM   2841 O  O   . ALA B 1 119 ? -13.03029 -11.93739 -22.36633 1.000 11.10517 ? 119 ALA B O   1 
ATOM   2842 C  CB  . ALA B 1 119 ? -12.72292 -8.70727  -22.51668 1.000 11.49984 ? 119 ALA B CB  1 
ATOM   2843 N  N   . ASP B 1 120 ? -13.32915 -10.98278 -20.35443 1.000 10.02698 ? 120 ASP B N   1 
ATOM   2844 C  CA  . ASP B 1 120 ? -14.34133 -11.96069 -19.97050 1.000 10.46106 ? 120 ASP B CA  1 
ATOM   2845 C  C   . ASP B 1 120 ? -15.32833 -11.26561 -19.04834 1.000 13.18242 ? 120 ASP B C   1 
ATOM   2846 O  O   . ASP B 1 120 ? -15.09147 -10.15496 -18.58330 1.000 10.50258 ? 120 ASP B O   1 
ATOM   2847 C  CB  . ASP B 1 120 ? -13.69270 -13.17119 -19.28946 1.000 13.45914 ? 120 ASP B CB  1 
ATOM   2848 C  CG  . ASP B 1 120 ? -14.54561 -14.44491 -19.37000 1.000 20.01726 ? 120 ASP B CG  1 
ATOM   2849 O  OD1 . ASP B 1 120 ? -15.78328 -14.39255 -19.60137 1.000 21.42543 ? 120 ASP B OD1 1 
ATOM   2850 O  OD2 . ASP B 1 120 ? -13.94350 -15.52532 -19.18523 1.000 32.51188 ? 120 ASP B OD2 1 
ATOM   2851 N  N   . GLY B 1 121 ? -16.44895 -11.93412 -18.77152 1.000 16.15845 ? 121 GLY B N   1 
ATOM   2852 C  CA  . GLY B 1 121 ? -17.36730 -11.37595 -17.79665 1.000 18.98597 ? 121 GLY B CA  1 
ATOM   2853 C  C   . GLY B 1 121 ? -16.70098 -10.98786 -16.48441 1.000 13.72036 ? 121 GLY B C   1 
ATOM   2854 O  O   . GLY B 1 121 ? -15.99813 -11.79063 -15.87328 1.000 20.18179 ? 121 GLY B O   1 
ATOM   2855 N  N   . GLY B 1 122 ? -16.87970 -9.73269  -16.08652 1.000 16.76133 ? 122 GLY B N   1 
ATOM   2856 C  CA  . GLY B 1 122 ? -16.27062 -9.19501  -14.88400 1.000 17.91508 ? 122 GLY B CA  1 
ATOM   2857 C  C   . GLY B 1 122 ? -14.77763 -8.91040  -14.95514 1.000 19.44591 ? 122 GLY B C   1 
ATOM   2858 O  O   . GLY B 1 122 ? -14.21120 -8.43768  -13.95713 1.000 17.68273 ? 122 GLY B O   1 
ATOM   2859 N  N   . ARG B 1 123 ? -14.10756 -9.18410  -16.07486 1.000 14.31302 ? 123 ARG B N   1 
ATOM   2860 C  CA  . ARG B 1 123 ? -12.66159 -8.94860  -16.17606 1.000 13.46509 ? 123 ARG B CA  1 
ATOM   2861 C  C   . ARG B 1 123 ? -12.36049 -8.30432  -17.51617 1.000 9.74675  ? 123 ARG B C   1 
ATOM   2862 O  O   . ARG B 1 123 ? -12.08898 -8.99229  -18.50397 1.000 9.30450  ? 123 ARG B O   1 
ATOM   2863 C  CB  . ARG B 1 123 ? -11.83493 -10.21853 -15.99483 1.000 13.08566 ? 123 ARG B CB  1 
ATOM   2864 C  CG  . ARG B 1 123 ? -10.29770 -9.94400  -15.94984 1.000 14.00243 ? 123 ARG B CG  1 
ATOM   2865 C  CD  . ARG B 1 123 ? -9.88196  -9.34546  -14.63423 1.000 12.53604 ? 123 ARG B CD  1 
ATOM   2866 N  NE  . ARG B 1 123 ? -8.48086  -8.91872  -14.68371 1.000 11.05946 ? 123 ARG B NE  1 
ATOM   2867 C  CZ  . ARG B 1 123 ? -7.42360  -9.69768  -14.49453 1.000 12.46798 ? 123 ARG B CZ  1 
ATOM   2868 N  NH1 . ARG B 1 123 ? -7.55250  -10.98183 -14.17192 1.000 14.83458 ? 123 ARG B NH1 1 
ATOM   2869 N  NH2 . ARG B 1 123 ? -6.20172  -9.15786  -14.60157 1.000 10.27925 ? 123 ARG B NH2 1 
ATOM   2870 N  N   . PRO B 1 124 ? -12.38291 -6.98020  -17.56684 1.000 9.22356  ? 124 PRO B N   1 
ATOM   2871 C  CA  . PRO B 1 124 ? -12.04033 -6.27440  -18.80901 1.000 7.97997  ? 124 PRO B CA  1 
ATOM   2872 C  C   . PRO B 1 124 ? -10.57784 -6.52569  -19.13636 1.000 8.04194  ? 124 PRO B C   1 
ATOM   2873 O  O   . PRO B 1 124 ? -9.77745  -6.95936  -18.28924 1.000 12.53801 ? 124 PRO B O   1 
ATOM   2874 C  CB  . PRO B 1 124 ? -12.28828 -4.79502  -18.47389 1.000 10.26129 ? 124 PRO B CB  1 
ATOM   2875 C  CG  . PRO B 1 124 ? -13.11288 -4.80474  -17.23181 1.000 16.49716 ? 124 PRO B CG  1 
ATOM   2876 C  CD  . PRO B 1 124 ? -12.75061 -6.05814  -16.48397 1.000 12.67261 ? 124 PRO B CD  1 
ATOM   2877 N  N   . GLY B 1 125 ? -10.23705 -6.29600  -20.39807 1.000 7.06893  ? 125 GLY B N   1 
ATOM   2878 C  CA  . GLY B 1 125 ? -8.85754  -6.39733  -20.79488 1.000 7.67619  ? 125 GLY B CA  1 
ATOM   2879 C  C   . GLY B 1 125 ? -8.24918  -5.03231  -20.97068 1.000 9.13349  ? 125 GLY B C   1 
ATOM   2880 O  O   . GLY B 1 125 ? -8.62611  -4.26486  -21.86538 1.000 9.32002  ? 125 GLY B O   1 
ATOM   2881 N  N   . PRO B 1 126 ? -7.30679  -4.68186  -20.11563 1.000 6.95350  ? 126 PRO B N   1 
ATOM   2882 C  CA  . PRO B 1 126 ? -6.73395  -3.33673  -20.21134 1.000 7.61933  ? 126 PRO B CA  1 
ATOM   2883 C  C   . PRO B 1 126 ? -5.81549  -3.22821  -21.42038 1.000 7.97656  ? 126 PRO B C   1 
ATOM   2884 O  O   . PRO B 1 126 ? -5.02843  -4.13516  -21.73985 1.000 10.52999 ? 126 PRO B O   1 
ATOM   2885 C  CB  . PRO B 1 126 ? -5.95931  -3.15094  -18.89592 1.000 11.92427 ? 126 PRO B CB  1 
ATOM   2886 C  CG  . PRO B 1 126 ? -6.32035  -4.29372  -18.05235 1.000 16.92184 ? 126 PRO B CG  1 
ATOM   2887 C  CD  . PRO B 1 126 ? -6.84961  -5.41167  -18.92154 1.000 10.26129 ? 126 PRO B CD  1 
ATOM   2888 N  N   . LEU B 1 127 ? -5.87493  -2.07702  -22.06913 1.000 8.70860  ? 127 LEU B N   1 
ATOM   2889 C  CA  . LEU B 1 127 ? -5.10137  -1.85933  -23.27543 1.000 7.40776  ? 127 LEU B CA  1 
ATOM   2890 C  C   . LEU B 1 127 ? -3.98123  -0.86961  -23.06869 1.000 11.04597 ? 127 LEU B C   1 
ATOM   2891 O  O   . LEU B 1 127 ? -2.91655  -1.02657  -23.65745 1.000 13.63285 ? 127 LEU B O   1 
ATOM   2892 C  CB  . LEU B 1 127 ? -6.00696  -1.37153  -24.41076 1.000 9.54199  ? 127 LEU B CB  1 
ATOM   2893 C  CG  . LEU B 1 127 ? -7.03397  -2.38802  -24.89921 1.000 9.46480  ? 127 LEU B CG  1 
ATOM   2894 C  CD1 . LEU B 1 127 ? -7.92156  -1.79390  -25.99673 1.000 10.97966 ? 127 LEU B CD1 1 
ATOM   2895 C  CD2 . LEU B 1 127 ? -6.27224  -3.58638  -25.45690 1.000 8.82965  ? 127 LEU B CD2 1 
ATOM   2896 N  N   . THR B 1 128 ? -4.20175  0.15165   -22.24676 1.000 11.81043 ? 128 THR B N   1 
ATOM   2897 C  CA  . THR B 1 128 ? -3.17725  1.15485   -21.96473 1.000 8.96951  ? 128 THR B CA  1 
ATOM   2898 C  C   . THR B 1 128 ? -3.12798  1.36560   -20.45211 1.000 9.71348  ? 128 THR B C   1 
ATOM   2899 O  O   . THR B 1 128 ? -3.53725  2.40725   -19.93604 1.000 12.81112 ? 128 THR B O   1 
ATOM   2900 C  CB  . THR B 1 128 ? -3.42954  2.46654   -22.71983 1.000 9.21383  ? 128 THR B CB  1 
ATOM   2901 O  OG1 . THR B 1 128 ? -4.71956  2.98584   -22.38276 1.000 10.30401 ? 128 THR B OG1 1 
ATOM   2902 C  CG2 . THR B 1 128 ? -3.40322  2.26280   -24.25656 1.000 9.40661  ? 128 THR B CG2 1 
ATOM   2903 N  N   . PRO B 1 129 ? -2.56685  0.40032   -19.70814 1.000 12.98412 ? 129 PRO B N   1 
ATOM   2904 C  CA  . PRO B 1 129 ? -2.29185  0.63980   -18.28820 1.000 15.27153 ? 129 PRO B CA  1 
ATOM   2905 C  C   . PRO B 1 129 ? -1.30230  1.77725   -18.03323 1.000 16.66668 ? 129 PRO B C   1 
ATOM   2906 O  O   . PRO B 1 129 ? -1.30193  2.32122   -16.91793 1.000 23.12468 ? 129 PRO B O   1 
ATOM   2907 C  CB  . PRO B 1 129 ? -1.74550  -0.71211  -17.80126 1.000 14.37182 ? 129 PRO B CB  1 
ATOM   2908 C  CG  . PRO B 1 129 ? -1.28787  -1.43298  -19.02121 1.000 14.41136 ? 129 PRO B CG  1 
ATOM   2909 C  CD  . PRO B 1 129 ? -2.13436  -0.93369  -20.17157 1.000 13.50289 ? 129 PRO B CD  1 
ATOM   2910 N  N   . GLU B 1 130 ? -0.49966  2.16964   -19.02743 1.000 15.28427 ? 130 GLU B N   1 
ATOM   2911 C  CA  . GLU B 1 130 ? 0.31011   3.38983   -18.99632 1.000 16.53120 ? 130 GLU B CA  1 
ATOM   2912 C  C   . GLU B 1 130 ? -0.53249  4.65046   -18.78292 1.000 16.84097 ? 130 GLU B C   1 
ATOM   2913 O  O   . GLU B 1 130 ? 0.02037   5.68549   -18.38458 1.000 24.28403 ? 130 GLU B O   1 
ATOM   2914 C  CB  . GLU B 1 130 ? 1.08844   3.54654   -20.32157 1.000 16.43950 ? 130 GLU B CB  1 
ATOM   2915 C  CG  . GLU B 1 130 ? 1.92979   2.34039   -20.77058 1.000 22.33726 ? 130 GLU B CG  1 
ATOM   2916 C  CD  . GLU B 1 130 ? 1.18334   1.36025   -21.68770 1.000 26.57726 ? 130 GLU B CD  1 
ATOM   2917 O  OE1 . GLU B 1 130 ? -0.05863  1.28137   -21.63938 1.000 20.38905 ? 130 GLU B OE1 1 
ATOM   2918 O  OE2 . GLU B 1 130 ? 1.83616   0.65610   -22.49480 1.000 28.38726 ? 130 GLU B OE2 1 
ATOM   2919 N  N   . GLY B 1 131 ? -1.84383  4.59849   -19.04486 1.000 13.41004 ? 131 GLY B N   1 
ATOM   2920 C  CA  . GLY B 1 131 ? -2.65679  5.81969   -19.08727 1.000 12.60672 ? 131 GLY B CA  1 
ATOM   2921 C  C   . GLY B 1 131 ? -2.40842  6.56568   -20.39028 1.000 9.12315  ? 131 GLY B C   1 
ATOM   2922 O  O   . GLY B 1 131 ? -1.92518  5.99167   -21.35899 1.000 11.18865 ? 131 GLY B O   1 
ATOM   2923 N  N   . VAL B 1 132 ? -2.74858  7.86297   -20.40661 1.000 8.61427  ? 132 VAL B N   1 
ATOM   2924 C  CA  . VAL B 1 132 ? -2.50658  8.69741   -21.57490 1.000 6.45042  ? 132 VAL B CA  1 
ATOM   2925 C  C   . VAL B 1 132 ? -0.99726  8.83552   -21.72602 1.000 9.89263  ? 132 VAL B C   1 
ATOM   2926 O  O   . VAL B 1 132 ? -0.29700  9.19572   -20.76627 1.000 12.21363 ? 132 VAL B O   1 
ATOM   2927 C  CB  . VAL B 1 132 ? -3.18412  10.07205  -21.40388 1.000 9.68168  ? 132 VAL B CB  1 
ATOM   2928 C  CG1 . VAL B 1 132 ? -2.79532  10.99300  -22.56350 1.000 11.60729 ? 132 VAL B CG1 1 
ATOM   2929 C  CG2 . VAL B 1 132 ? -4.70032  9.94088   -21.35074 1.000 13.83499 ? 132 VAL B CG2 1 
ATOM   2930 N  N   . HIS B 1 133 ? -0.47153  8.52185   -22.90267 1.000 8.32384  ? 133 HIS B N   1 
ATOM   2931 C  CA  . HIS B 1 133 ? 0.98603   8.41534   -23.00159 1.000 9.52124  ? 133 HIS B CA  1 
ATOM   2932 C  C   . HIS B 1 133 ? 1.44513   8.72804   -24.41368 1.000 6.34751  ? 133 HIS B C   1 
ATOM   2933 O  O   . HIS B 1 133 ? 0.68518   8.65726   -25.38404 1.000 8.18078  ? 133 HIS B O   1 
ATOM   2934 C  CB  . HIS B 1 133 ? 1.51166   6.99880   -22.61920 1.000 9.87557  ? 133 HIS B CB  1 
ATOM   2935 C  CG  . HIS B 1 133 ? 1.01071   5.92582   -23.52715 1.000 8.21745  ? 133 HIS B CG  1 
ATOM   2936 N  ND1 . HIS B 1 133 ? -0.26813  5.40870   -23.41405 1.000 9.69918  ? 133 HIS B ND1 1 
ATOM   2937 C  CD2 . HIS B 1 133 ? 1.58476   5.31650   -24.58659 1.000 10.96296 ? 133 HIS B CD2 1 
ATOM   2938 C  CE1 . HIS B 1 133 ? -0.44849  4.50806   -24.36350 1.000 9.24683  ? 133 HIS B CE1 1 
ATOM   2939 N  NE2 . HIS B 1 133 ? 0.65044   4.44897   -25.09786 1.000 10.40236 ? 133 HIS B NE2 1 
ATOM   2940 N  N   . HIS B 1 134 ? 2.75918   9.01258   -24.51742 1.000 9.22880  ? 134 HIS B N   1 
ATOM   2941 C  CA  . HIS B 1 134 ? 3.50437   8.88209   -25.76526 1.000 9.54470  ? 134 HIS B CA  1 
ATOM   2942 C  C   . HIS B 1 134 ? 4.28809   7.57780   -25.73479 1.000 8.67581  ? 134 HIS B C   1 
ATOM   2943 O  O   . HIS B 1 134 ? 4.76892   7.17878   -24.68103 1.000 10.76769 ? 134 HIS B O   1 
ATOM   2944 C  CB  . HIS B 1 134 ? 4.49469   10.03277  -25.91087 1.000 11.82221 ? 134 HIS B CB  1 
ATOM   2945 C  CG  . HIS B 1 134 ? 3.86251   11.37025  -25.83467 1.000 11.27255 ? 134 HIS B CG  1 
ATOM   2946 N  ND1 . HIS B 1 134 ? 3.42232   12.05632  -26.94128 1.000 13.35503 ? 134 HIS B ND1 1 
ATOM   2947 C  CD2 . HIS B 1 134 ? 3.60379   12.16400  -24.76873 1.000 17.37811 ? 134 HIS B CD2 1 
ATOM   2948 C  CE1 . HIS B 1 134 ? 2.92662   13.22498  -26.56706 1.000 13.78786 ? 134 HIS B CE1 1 
ATOM   2949 N  NE2 . HIS B 1 134 ? 3.01502   13.30941  -25.25337 1.000 14.83652 ? 134 HIS B NE2 1 
ATOM   2950 N  N   . ASP B 1 135 ? 4.40000   6.89138   -26.88797 1.000 8.80454  ? 135 ASP B N   1 
ATOM   2951 C  CA  . ASP B 1 135 ? 5.23833   5.68742   -26.93590 1.000 10.27446 ? 135 ASP B CA  1 
ATOM   2952 C  C   . ASP B 1 135 ? 6.73325   6.00337   -26.90159 1.000 11.90064 ? 135 ASP B C   1 
ATOM   2953 O  O   . ASP B 1 135 ? 7.51815   5.13446   -26.51527 1.000 12.67326 ? 135 ASP B O   1 
ATOM   2954 C  CB  . ASP B 1 135 ? 4.99054   4.85259   -28.20497 1.000 11.16824 ? 135 ASP B CB  1 
ATOM   2955 C  CG  . ASP B 1 135 ? 3.66104   4.10133   -28.21493 1.000 14.76217 ? 135 ASP B CG  1 
ATOM   2956 O  OD1 . ASP B 1 135 ? 2.78652   4.31821   -27.33667 1.000 10.05885 ? 135 ASP B OD1 1 
ATOM   2957 O  OD2 . ASP B 1 135 ? 3.49555   3.26896   -29.14759 1.000 16.84199 ? 135 ASP B OD2 1 
ATOM   2958 N  N   . GLY B 1 136 ? 7.12484   7.21550   -27.28486 1.000 11.50532 ? 136 GLY B N   1 
ATOM   2959 C  CA  . GLY B 1 136 ? 8.50927   7.61463   -27.31266 1.000 10.39711 ? 136 GLY B CA  1 
ATOM   2960 C  C   . GLY B 1 136 ? 9.12182   7.60352   -28.68803 1.000 11.78275 ? 136 GLY B C   1 
ATOM   2961 O  O   . GLY B 1 136 ? 10.30840  7.94146   -28.82007 1.000 14.12409 ? 136 GLY B O   1 
ATOM   2962 N  N   . HIS B 1 137 ? 8.36234   7.24220   -29.70840 1.000 10.74687 ? 137 HIS B N   1 
ATOM   2963 C  CA  . HIS B 1 137 ? 8.84042   7.11907   -31.07379 1.000 9.11177  ? 137 HIS B CA  1 
ATOM   2964 C  C   . HIS B 1 137 ? 8.35688   8.32039   -31.89104 1.000 13.37375 ? 137 HIS B C   1 
ATOM   2965 O  O   . HIS B 1 137 ? 7.69220   9.23588   -31.37846 1.000 17.69001 ? 137 HIS B O   1 
ATOM   2966 C  CB  . HIS B 1 137 ? 8.35587   5.80501   -31.68859 1.000 8.98527  ? 137 HIS B CB  1 
ATOM   2967 C  CG  . HIS B 1 137 ? 8.83342   4.57203   -30.97127 1.000 11.28966 ? 137 HIS B CG  1 
ATOM   2968 N  ND1 . HIS B 1 137 ? 9.89400   3.80820   -31.41124 1.000 11.43404 ? 137 HIS B ND1 1 
ATOM   2969 C  CD2 . HIS B 1 137 ? 8.38700   3.97008   -29.83944 1.000 11.78323 ? 137 HIS B CD2 1 
ATOM   2970 C  CE1 . HIS B 1 137 ? 10.06794  2.78287   -30.59797 1.000 9.74260  ? 137 HIS B CE1 1 
ATOM   2971 N  NE2 . HIS B 1 137 ? 9.16811   2.86058   -29.62915 1.000 10.23503 ? 137 HIS B NE2 1 
ATOM   2972 N  N   . GLU B 1 138 ? 8.68510   8.32328   -33.17797 1.000 7.65938  ? 138 GLU B N   1 
ATOM   2973 C  CA  . GLU B 1 138 ? 8.27348   9.41357   -34.05148 1.000 9.84827  ? 138 GLU B CA  1 
ATOM   2974 C  C   . GLU B 1 138 ? 6.86339   9.17500   -34.58822 1.000 10.37779 ? 138 GLU B C   1 
ATOM   2975 O  O   . GLU B 1 138 ? 6.02188   10.08770  -34.55009 1.000 12.14798 ? 138 GLU B O   1 
ATOM   2976 C  CB  . GLU B 1 138 ? 9.29540   9.60545   -35.19852 1.000 13.07775 ? 138 GLU B CB  1 
ATOM   2977 C  CG  . GLU B 1 138 ? 9.08757   10.88931  -36.01781 1.000 13.48794 ? 138 GLU B CG  1 
ATOM   2978 C  CD  . GLU B 1 138 ? 10.30603  11.26032  -36.85774 1.000 13.94452 ? 138 GLU B CD  1 
ATOM   2979 O  OE1 . GLU B 1 138 ? 11.37581  10.64230  -36.67261 1.000 20.16614 ? 138 GLU B OE1 1 
ATOM   2980 O  OE2 . GLU B 1 138 ? 10.18174  12.17812  -37.68782 1.000 19.60174 ? 138 GLU B OE2 1 
ATOM   2981 N  N   . PHE B 1 139 ? 6.59869   7.96826   -35.12026 1.000 8.91553  ? 139 PHE B N   1 
ATOM   2982 C  CA  . PHE B 1 139 ? 5.25959   7.62262   -35.57711 1.000 7.91072  ? 139 PHE B CA  1 
ATOM   2983 C  C   . PHE B 1 139 ? 4.87169   6.28329   -34.97069 1.000 7.71765  ? 139 PHE B C   1 
ATOM   2984 O  O   . PHE B 1 139 ? 5.73411   5.44636   -34.65952 1.000 8.15282  ? 139 PHE B O   1 
ATOM   2985 C  CB  . PHE B 1 139 ? 5.17958   7.53271   -37.09247 1.000 9.86581  ? 139 PHE B CB  1 
ATOM   2986 C  CG  . PHE B 1 139 ? 5.58197   8.79405   -37.80155 1.000 10.24199 ? 139 PHE B CG  1 
ATOM   2987 C  CD1 . PHE B 1 139 ? 4.79520   9.90043   -37.74283 1.000 13.61116 ? 139 PHE B CD1 1 
ATOM   2988 C  CD2 . PHE B 1 139 ? 6.75858   8.82477   -38.54746 1.000 13.27828 ? 139 PHE B CD2 1 
ATOM   2989 C  CE1 . PHE B 1 139 ? 5.18270   11.08550  -38.40281 1.000 15.95442 ? 139 PHE B CE1 1 
ATOM   2990 C  CE2 . PHE B 1 139 ? 7.13344   9.97513   -39.24119 1.000 16.67462 ? 139 PHE B CE2 1 
ATOM   2991 C  CZ  . PHE B 1 139 ? 6.33167   11.09606  -39.15491 1.000 15.80352 ? 139 PHE B CZ  1 
ATOM   2992 N  N   . VAL B 1 140 ? 3.56783   6.07987   -34.82858 1.000 7.45411  ? 140 VAL B N   1 
ATOM   2993 C  CA  . VAL B 1 140 ? 3.02638   4.79007   -34.39614 1.000 5.88517  ? 140 VAL B CA  1 
ATOM   2994 C  C   . VAL B 1 140 ? 1.87503   4.41428   -35.31885 1.000 8.09668  ? 140 VAL B C   1 
ATOM   2995 O  O   . VAL B 1 140 ? 1.07435   5.26761   -35.70948 1.000 9.40445  ? 140 VAL B O   1 
ATOM   2996 C  CB  . VAL B 1 140 ? 2.56689   4.83333   -32.90515 1.000 7.36817  ? 140 VAL B CB  1 
ATOM   2997 C  CG1 . VAL B 1 140 ? 1.78494   3.57193   -32.52734 1.000 12.33952 ? 140 VAL B CG1 1 
ATOM   2998 C  CG2 . VAL B 1 140 ? 3.76912   4.93030   -31.97557 1.000 10.93922 ? 140 VAL B CG2 1 
ATOM   2999 N  N   . MET B 1 141 ? 1.80989   3.13511   -35.68664 1.000 6.68493  ? 141 MET B N   1 
ATOM   3000 C  CA  . MET B 1 141 ? 0.68834   2.55928   -36.41091 1.000 7.81909  ? 141 MET B CA  1 
ATOM   3001 C  C   . MET B 1 141 ? 0.04495   1.49545   -35.53907 1.000 5.78924  ? 141 MET B C   1 
ATOM   3002 O  O   . MET B 1 141 ? 0.73020   0.60037   -35.04269 1.000 7.62390  ? 141 MET B O   1 
ATOM   3003 C  CB  . MET B 1 141 ? 1.16400   1.91671   -37.72422 1.000 9.21426  ? 141 MET B CB  1 
ATOM   3004 C  CG  . MET B 1 141 ? 0.04107   1.11334   -38.42340 1.000 9.04657  ? 141 MET B CG  1 
ATOM   3005 S  SD  . MET B 1 141 ? 0.67628   0.58341   -40.04890 1.000 10.21455 ? 141 MET B SD  1 
ATOM   3006 C  CE  . MET B 1 141 ? -0.80511  -0.04306  -40.82289 1.000 14.87570 ? 141 MET B CE  1 
ATOM   3007 N  N   . ILE B 1 142 ? -1.25741  1.59738   -35.31840 1.000 7.04810  ? 142 ILE B N   1 
ATOM   3008 C  CA  . ILE B 1 142 ? -1.97122  0.55650   -34.58178 1.000 7.19700  ? 142 ILE B CA  1 
ATOM   3009 C  C   . ILE B 1 142 ? -3.03540  -0.01395  -35.50041 1.000 8.08794  ? 142 ILE B C   1 
ATOM   3010 O  O   . ILE B 1 142 ? -3.93050  0.72162   -35.94602 1.000 7.15165  ? 142 ILE B O   1 
ATOM   3011 C  CB  . ILE B 1 142 ? -2.60990  1.08757   -33.29748 1.000 7.32469  ? 142 ILE B CB  1 
ATOM   3012 C  CG1 . ILE B 1 142 ? -1.52971  1.55260   -32.31791 1.000 8.88205  ? 142 ILE B CG1 1 
ATOM   3013 C  CG2 . ILE B 1 142 ? -3.43905  -0.03301  -32.67348 1.000 9.61937  ? 142 ILE B CG2 1 
ATOM   3014 C  CD1 . ILE B 1 142 ? -2.00778  2.72201   -31.47852 1.000 13.32272 ? 142 ILE B CD1 1 
ATOM   3015 N  N   . ALA B 1 143 ? -2.93203  -1.31703  -35.80932 1.000 6.72422  ? 143 ALA B N   1 
ATOM   3016 C  CA  . ALA B 1 143 ? -3.85089  -1.94310  -36.76080 1.000 5.32582  ? 143 ALA B CA  1 
ATOM   3017 C  C   . ALA B 1 143 ? -4.66468  -3.01125  -36.05370 1.000 6.79846  ? 143 ALA B C   1 
ATOM   3018 O  O   . ALA B 1 143 ? -4.11489  -3.81308  -35.29621 1.000 7.03723  ? 143 ALA B O   1 
ATOM   3019 C  CB  . ALA B 1 143 ? -3.10824  -2.59975  -37.93624 1.000 6.39350  ? 143 ALA B CB  1 
ATOM   3020 N  N   . ILE B 1 144 ? -5.96901  -3.03776  -36.31232 1.000 5.46924  ? 144 ILE B N   1 
ATOM   3021 C  CA  . ILE B 1 144 ? -6.86481  -4.03138  -35.70628 1.000 7.03111  ? 144 ILE B CA  1 
ATOM   3022 C  C   . ILE B 1 144 ? -7.09607  -5.17033  -36.69616 1.000 8.39043  ? 144 ILE B C   1 
ATOM   3023 O  O   . ILE B 1 144 ? -7.63653  -4.95234  -37.80625 1.000 8.24026  ? 144 ILE B O   1 
ATOM   3024 C  CB  . ILE B 1 144 ? -8.19548  -3.39880  -35.29605 1.000 5.75212  ? 144 ILE B CB  1 
ATOM   3025 C  CG1 . ILE B 1 144 ? -7.99561  -2.03410  -34.67183 1.000 12.30871 ? 144 ILE B CG1 1 
ATOM   3026 C  CG2 . ILE B 1 144 ? -9.08125  -4.41689  -34.50426 1.000 8.76181  ? 144 ILE B CG2 1 
ATOM   3027 C  CD1 . ILE B 1 144 ? -7.25377  -2.03016  -33.41705 1.000 11.03517 ? 144 ILE B CD1 1 
ATOM   3028 N  N   . LEU B 1 145 ? -6.69656  -6.38244  -36.29154 1.000 4.63135  ? 145 LEU B N   1 
ATOM   3029 C  CA  . LEU B 1 145 ? -6.83225  -7.53760  -37.17716 1.000 7.15079  ? 145 LEU B CA  1 
ATOM   3030 C  C   . LEU B 1 145 ? -8.10371  -8.35025  -36.92350 1.000 8.03495  ? 145 LEU B C   1 
ATOM   3031 O  O   . LEU B 1 145 ? -8.66916  -8.89631  -37.87194 1.000 10.43889 ? 145 LEU B O   1 
ATOM   3032 C  CB  . LEU B 1 145 ? -5.59877  -8.45922  -37.05748 1.000 10.58282 ? 145 LEU B CB  1 
ATOM   3033 C  CG  . LEU B 1 145 ? -4.27440  -8.14510  -37.79940 1.000 12.68944 ? 145 LEU B CG  1 
ATOM   3034 C  CD1 . LEU B 1 145 ? -4.43863  -8.29396  -39.31041 1.000 14.07177 ? 145 LEU B CD1 1 
ATOM   3035 C  CD2 . LEU B 1 145 ? -3.78543  -6.72518  -37.46115 1.000 12.03833 ? 145 LEU B CD2 1 
ATOM   3036 N  N   . ASN B 1 146 ? -8.59041  -8.43776  -35.69668 1.000 6.37428  ? 146 ASN B N   1 
ATOM   3037 C  CA  . ASN B 1 146 ? -9.75185  -9.26304  -35.42226 1.000 5.56998  ? 146 ASN B CA  1 
ATOM   3038 C  C   . ASN B 1 146 ? -10.30845 -8.79408  -34.10272 1.000 7.97160  ? 146 ASN B C   1 
ATOM   3039 O  O   . ASN B 1 146 ? -9.53667  -8.49696  -33.18473 1.000 9.69774  ? 146 ASN B O   1 
ATOM   3040 C  CB  . ASN B 1 146 ? -9.36091  -10.75614 -35.32831 1.000 8.80092  ? 146 ASN B CB  1 
ATOM   3041 C  CG  . ASN B 1 146 ? -10.54614 -11.70177 -35.49110 1.000 17.94760 ? 146 ASN B CG  1 
ATOM   3042 O  OD1 . ASN B 1 146 ? -11.66650 -11.27964 -35.73757 1.000 18.57761 ? 146 ASN B OD1 1 
ATOM   3043 N  ND2 . ASN B 1 146 ? -10.27831 -12.99777 -35.37264 1.000 23.00414 ? 146 ASN B ND2 1 
ATOM   3044 N  N   . LYS B 1 147 ? -11.63720 -8.74624  -34.01273 1.000 6.99506  ? 147 LYS B N   1 
ATOM   3045 C  CA  . LYS B 1 147 ? -12.34632 -8.53167  -32.75772 1.000 6.50691  ? 147 LYS B CA  1 
ATOM   3046 C  C   . LYS B 1 147 ? -13.44601 -9.56391  -32.68953 1.000 10.48631 ? 147 LYS B C   1 
ATOM   3047 O  O   . LYS B 1 147 ? -14.20228 -9.72566  -33.65853 1.000 10.80280 ? 147 LYS B O   1 
ATOM   3048 C  CB  . LYS B 1 147 ? -12.97401 -7.12648  -32.66184 1.000 5.42977  ? 147 LYS B CB  1 
ATOM   3049 C  CG  . LYS B 1 147 ? -11.90031 -6.08233  -32.40387 1.000 12.28961 ? 147 LYS B CG  1 
ATOM   3050 C  CD  . LYS B 1 147 ? -12.43882 -4.70199  -32.51872 1.000 9.91544  ? 147 LYS B CD  1 
ATOM   3051 C  CE  . LYS B 1 147 ? -13.35205 -4.39584  -31.41130 1.000 10.80581 ? 147 LYS B CE  1 
ATOM   3052 N  NZ  . LYS B 1 147 ? -13.70857 -2.89807  -31.43089 1.000 11.43610 ? 147 LYS B NZ  1 
ATOM   3053 N  N   . VAL B 1 148 ? -13.50650 -10.28038 -31.57032 1.000 7.91734  ? 148 VAL B N   1 
ATOM   3054 C  CA  . VAL B 1 148 ? -14.51275 -11.32024 -31.34995 1.000 8.40651  ? 148 VAL B CA  1 
ATOM   3055 C  C   . VAL B 1 148 ? -15.17360 -11.07827 -29.99778 1.000 11.84015 ? 148 VAL B C   1 
ATOM   3056 O  O   . VAL B 1 148 ? -14.51176 -11.15929 -28.94824 1.000 7.91983  ? 148 VAL B O   1 
ATOM   3057 C  CB  . VAL B 1 148 ? -13.89291 -12.72479 -31.39978 1.000 10.60920 ? 148 VAL B CB  1 
ATOM   3058 C  CG1 . VAL B 1 148 ? -14.91665 -13.77953 -31.04935 1.000 13.68834 ? 148 VAL B CG1 1 
ATOM   3059 C  CG2 . VAL B 1 148 ? -13.27095 -13.00521 -32.80752 1.000 11.12521 ? 148 VAL B CG2 1 
ATOM   3060 N  N   . ASN B 1 149 ? -16.48376 -10.78047 -30.02251 1.000 9.19481  ? 149 ASN B N   1 
ATOM   3061 C  CA  . ASN B 1 149 ? -17.31369 -10.72564 -28.81775 1.000 9.66680  ? 149 ASN B CA  1 
ATOM   3062 C  C   . ASN B 1 149 ? -16.79193 -9.71065  -27.81183 1.000 8.70791  ? 149 ASN B C   1 
ATOM   3063 O  O   . ASN B 1 149 ? -16.83009 -9.94634  -26.59533 1.000 10.04996 ? 149 ASN B O   1 
ATOM   3064 C  CB  . ASN B 1 149 ? -17.42917 -12.10172 -28.16080 1.000 8.81058  ? 149 ASN B CB  1 
ATOM   3065 C  CG  . ASN B 1 149 ? -18.54313 -12.15861 -27.12464 1.000 13.05664 ? 149 ASN B CG  1 
ATOM   3066 O  OD1 . ASN B 1 149 ? -19.61329 -11.58123 -27.31897 1.000 14.21924 ? 149 ASN B OD1 1 
ATOM   3067 N  ND2 . ASN B 1 149 ? -18.27704 -12.82093 -25.98718 1.000 14.06367 ? 149 ASN B ND2 1 
ATOM   3068 N  N   . VAL B 1 150 ? -16.35456 -8.55649  -28.30852 1.000 10.66328 ? 150 VAL B N   1 
ATOM   3069 C  CA  . VAL B 1 150 ? -15.89600 -7.49765  -27.42526 1.000 12.63340 ? 150 VAL B CA  1 
ATOM   3070 C  C   . VAL B 1 150 ? -16.58738 -6.18331  -27.73088 1.000 11.52531 ? 150 VAL B C   1 
ATOM   3071 O  O   . VAL B 1 150 ? -17.06976 -5.92144  -28.84778 1.000 12.53035 ? 150 VAL B O   1 
ATOM   3072 C  CB  . VAL B 1 150 ? -14.38214 -7.30437  -27.49576 1.000 7.56142  ? 150 VAL B CB  1 
ATOM   3073 C  CG1 . VAL B 1 150 ? -13.69681 -8.59727  -27.00988 1.000 12.23709 ? 150 VAL B CG1 1 
ATOM   3074 C  CG2 . VAL B 1 150 ? -13.93017 -7.01137  -28.89932 1.000 11.51568 ? 150 VAL B CG2 1 
ATOM   3075 N  N   . ALA B 1 151 ? -16.67332 -5.37733  -26.69411 1.000 8.99415  ? 151 ALA B N   1 
ATOM   3076 C  CA  . ALA B 1 151 ? -17.05399 -3.98445  -26.78028 1.000 12.90250 ? 151 ALA B CA  1 
ATOM   3077 C  C   . ALA B 1 151 ? -15.92239 -3.14446  -26.19069 1.000 11.48876 ? 151 ALA B C   1 
ATOM   3078 O  O   . ALA B 1 151 ? -14.85149 -3.65431  -25.85113 1.000 11.44210 ? 151 ALA B O   1 
ATOM   3079 C  CB  . ALA B 1 151 ? -18.37894 -3.74550  -26.05454 1.000 18.55636 ? 151 ALA B CB  1 
ATOM   3080 N  N   . GLY B 1 152 ? -16.15267 -1.84283  -26.10743 1.000 12.36629 ? 152 GLY B N   1 
ATOM   3081 C  CA  . GLY B 1 152 ? -15.08949 -1.01429  -25.55871 1.000 12.71980 ? 152 GLY B CA  1 
ATOM   3082 C  C   . GLY B 1 152 ? -13.94226 -0.90003  -26.54406 1.000 8.09913  ? 152 GLY B C   1 
ATOM   3083 O  O   . GLY B 1 152 ? -14.10189 -1.02619  -27.76524 1.000 11.15118 ? 152 GLY B O   1 
ATOM   3084 N  N   . GLY B 1 153 ? -12.74903 -0.69599  -26.00982 1.000 9.12663  ? 153 GLY B N   1 
ATOM   3085 C  CA  . GLY B 1 153 ? -11.57873 -0.56975  -26.86972 1.000 9.47236  ? 153 GLY B CA  1 
ATOM   3086 C  C   . GLY B 1 153 ? -11.60227 0.66276   -27.74316 1.000 7.75104  ? 153 GLY B C   1 
ATOM   3087 O  O   . GLY B 1 153 ? -11.29203 0.59115   -28.93540 1.000 9.47827  ? 153 GLY B O   1 
ATOM   3088 N  N   . THR B 1 154 ? -11.95265 1.80571   -27.14677 1.000 8.59496  ? 154 THR B N   1 
ATOM   3089 C  CA  . THR B 1 154 ? -12.07513 3.05370   -27.89284 1.000 7.65717  ? 154 THR B CA  1 
ATOM   3090 C  C   . THR B 1 154 ? -10.77299 3.82842   -27.79016 1.000 7.07558  ? 154 THR B C   1 
ATOM   3091 O  O   . THR B 1 154 ? -10.33115 4.13516   -26.67766 1.000 8.42512  ? 154 THR B O   1 
ATOM   3092 C  CB  . THR B 1 154 ? -13.22031 3.87879   -27.33165 1.000 8.79831  ? 154 THR B CB  1 
ATOM   3093 O  OG1 . THR B 1 154 ? -14.41409 3.07392   -27.42148 1.000 12.50472 ? 154 THR B OG1 1 
ATOM   3094 C  CG2 . THR B 1 154 ? -13.39070 5.15326   -28.11200 1.000 12.71346 ? 154 THR B CG2 1 
ATOM   3095 N  N   . THR B 1 155 ? -10.18970 4.13883   -28.94157 1.000 6.02530  ? 155 THR B N   1 
ATOM   3096 C  CA  . THR B 1 155 ? -8.97222  4.94963   -29.01925 1.000 6.88218  ? 155 THR B CA  1 
ATOM   3097 C  C   . THR B 1 155 ? -9.31749  6.40868   -28.76028 1.000 9.39084  ? 155 THR B C   1 
ATOM   3098 O  O   . THR B 1 155 ? -10.27080 6.93250   -29.34035 1.000 9.20042  ? 155 THR B O   1 
ATOM   3099 C  CB  . THR B 1 155 ? -8.33770  4.80750   -30.39229 1.000 7.43261  ? 155 THR B CB  1 
ATOM   3100 O  OG1 . THR B 1 155 ? -7.98150  3.42161   -30.61129 1.000 10.92025 ? 155 THR B OG1 1 
ATOM   3101 C  CG2 . THR B 1 155 ? -7.07095  5.64361   -30.45461 1.000 8.62472  ? 155 THR B CG2 1 
ATOM   3102 N  N   . ARG B 1 156 ? -8.50687  7.07975   -27.91666 1.000 6.81641  ? 156 ARG B N   1 
ATOM   3103 C  CA  . ARG B 1 156 ? -8.67160  8.50098   -27.63873 1.000 8.84747  ? 156 ARG B CA  1 
ATOM   3104 C  C   . ARG B 1 156 ? -7.34809  9.19279   -27.89356 1.000 7.31602  ? 156 ARG B C   1 
ATOM   3105 O  O   . ARG B 1 156 ? -6.30276  8.72088   -27.44237 1.000 7.93292  ? 156 ARG B O   1 
ATOM   3106 C  CB  . ARG B 1 156 ? -9.13517  8.68965   -26.21034 1.000 8.09514  ? 156 ARG B CB  1 
ATOM   3107 C  CG  . ARG B 1 156 ? -10.43292 7.88747   -25.96831 1.000 12.63536 ? 156 ARG B CG  1 
ATOM   3108 C  CD  . ARG B 1 156 ? -10.97578 8.06780   -24.60562 1.000 23.72532 ? 156 ARG B CD  1 
ATOM   3109 N  NE  . ARG B 1 156 ? -10.07458 7.68945   -23.52993 1.000 12.31029 ? 156 ARG B NE  1 
ATOM   3110 C  CZ  . ARG B 1 156 ? -10.46635 7.74280   -22.27341 1.000 15.65518 ? 156 ARG B CZ  1 
ATOM   3111 N  NH1 . ARG B 1 156 ? -11.72271 8.04271   -21.96345 1.000 30.10147 ? 156 ARG B NH1 1 
ATOM   3112 N  NH2 . ARG B 1 156 ? -9.60157  7.47746   -21.31105 1.000 19.45279 ? 156 ARG B NH2 1 
ATOM   3113 N  N   . LEU B 1 157 ? -7.38929  10.28868  -28.65151 1.000 8.50365  ? 157 LEU B N   1 
ATOM   3114 C  CA  . LEU B 1 157 ? -6.19152  11.05613  -28.93785 1.000 7.43297  ? 157 LEU B CA  1 
ATOM   3115 C  C   . LEU B 1 157 ? -6.24254  12.38944  -28.19486 1.000 7.58518  ? 157 LEU B C   1 
ATOM   3116 O  O   . LEU B 1 157 ? -7.30189  13.01621  -28.10787 1.000 10.27038 ? 157 LEU B O   1 
ATOM   3117 C  CB  . LEU B 1 157 ? -6.06186  11.27057  -30.44143 1.000 7.81894  ? 157 LEU B CB  1 
ATOM   3118 C  CG  . LEU B 1 157 ? -6.08844  9.98579   -31.28658 1.000 10.72226 ? 157 LEU B CG  1 
ATOM   3119 C  CD1 . LEU B 1 157 ? -5.89231  10.33046  -32.77183 1.000 10.31764 ? 157 LEU B CD1 1 
ATOM   3120 C  CD2 . LEU B 1 157 ? -5.01320  9.04080   -30.81429 1.000 9.14843  ? 157 LEU B CD2 1 
ATOM   3121 N  N   . TRP B 1 158 ? -5.10473  12.78166  -27.62936 1.000 8.50942  ? 158 TRP B N   1 
ATOM   3122 C  CA  . TRP B 1 158 ? -5.00738  13.90106  -26.71235 1.000 9.37071  ? 158 TRP B CA  1 
ATOM   3123 C  C   . TRP B 1 158 ? -3.91726  14.86415  -27.14961 1.000 9.76242  ? 158 TRP B C   1 
ATOM   3124 O  O   . TRP B 1 158 ? -2.82552  14.45651  -27.55253 1.000 12.98331 ? 158 TRP B O   1 
ATOM   3125 C  CB  . TRP B 1 158 ? -4.66283  13.42087  -25.30877 1.000 11.42719 ? 158 TRP B CB  1 
ATOM   3126 C  CG  . TRP B 1 158 ? -5.57159  12.36080  -24.70658 1.000 9.20818  ? 158 TRP B CG  1 
ATOM   3127 C  CD1 . TRP B 1 158 ? -5.74269  11.05210  -25.15800 1.000 8.51391  ? 158 TRP B CD1 1 
ATOM   3128 C  CD2 . TRP B 1 158 ? -6.37538  12.48439  -23.54616 1.000 9.81579  ? 158 TRP B CD2 1 
ATOM   3129 N  NE1 . TRP B 1 158 ? -6.57803  10.38572  -24.31260 1.000 8.30149  ? 158 TRP B NE1 1 
ATOM   3130 C  CE2 . TRP B 1 158 ? -6.99467  11.24090  -23.32421 1.000 8.99012  ? 158 TRP B CE2 1 
ATOM   3131 C  CE3 . TRP B 1 158 ? -6.64343  13.53702  -22.65717 1.000 11.70991 ? 158 TRP B CE3 1 
ATOM   3132 C  CZ2 . TRP B 1 158 ? -7.85875  11.02530  -22.25942 1.000 12.05628 ? 158 TRP B CZ2 1 
ATOM   3133 C  CZ3 . TRP B 1 158 ? -7.49376  13.31403  -21.60689 1.000 14.89414 ? 158 TRP B CZ3 1 
ATOM   3134 C  CH2 . TRP B 1 158 ? -8.10083  12.06945  -21.41810 1.000 16.72400 ? 158 TRP B CH2 1 
ATOM   3135 N  N   . LYS B 1 159 ? -4.21740  16.14295  -27.02690 1.000 12.60396 ? 159 LYS B N   1 
ATOM   3136 C  CA  . LYS B 1 159 ? -3.12640  17.10489  -27.06257 1.000 11.55097 ? 159 LYS B CA  1 
ATOM   3137 C  C   . LYS B 1 159 ? -2.39476  17.08960  -25.71854 1.000 9.19164  ? 159 LYS B C   1 
ATOM   3138 O  O   . LYS B 1 159 ? -3.02243  16.93575  -24.67123 1.000 12.60071 ? 159 LYS B O   1 
ATOM   3139 C  CB  . LYS B 1 159 ? -3.67033  18.50958  -27.36189 1.000 19.53646 ? 159 LYS B CB  1 
ATOM   3140 C  CG  . LYS B 1 159 ? -4.54773  18.62507  -28.59757 1.000 27.87565 ? 159 LYS B CG  1 
ATOM   3141 C  CD  . LYS B 1 159 ? -3.75871  18.41869  -29.88597 1.000 26.29498 ? 159 LYS B CD  1 
ATOM   3142 C  CE  . LYS B 1 159 ? -4.66692  18.44490  -31.12310 1.000 35.75061 ? 159 LYS B CE  1 
ATOM   3143 N  NZ  . LYS B 1 159 ? -5.72444  19.50963  -31.07423 1.000 39.15502 ? 159 LYS B NZ  1 
ATOM   3144 N  N   . PRO B 1 160 ? -1.07773  17.20851  -25.71942 1.000 15.81376 ? 160 PRO B N   1 
ATOM   3145 C  CA  . PRO B 1 160 ? -0.33268  17.19268  -24.45620 1.000 14.42251 ? 160 PRO B CA  1 
ATOM   3146 C  C   . PRO B 1 160 ? -0.88380  18.19577  -23.45345 1.000 16.61780 ? 160 PRO B C   1 
ATOM   3147 O  O   . PRO B 1 160 ? -1.15073  19.35417  -23.79111 1.000 17.75544 ? 160 PRO B O   1 
ATOM   3148 C  CB  . PRO B 1 160 ? 1.09330   17.53090  -24.89508 1.000 20.78366 ? 160 PRO B CB  1 
ATOM   3149 C  CG  . PRO B 1 160 ? 1.17623   16.92332  -26.28713 1.000 20.50375 ? 160 PRO B CG  1 
ATOM   3150 C  CD  . PRO B 1 160 ? -0.18939  17.19987  -26.89514 1.000 14.39286 ? 160 PRO B CD  1 
ATOM   3151 N  N   . GLY B 1 161 ? -1.07735  17.71815  -22.22156 1.000 16.09306 ? 161 GLY B N   1 
ATOM   3152 C  CA  . GLY B 1 161 ? -1.64673  18.51395  -21.15137 1.000 17.98627 ? 161 GLY B CA  1 
ATOM   3153 C  C   . GLY B 1 161 ? -3.15773  18.63147  -21.14593 1.000 17.22781 ? 161 GLY B C   1 
ATOM   3154 O  O   . GLY B 1 161 ? -3.71630  19.13497  -20.16436 1.000 23.99185 ? 161 GLY B O   1 
ATOM   3155 N  N   . ALA B 1 162 ? -3.85209  18.21987  -22.20452 1.000 15.71977 ? 162 ALA B N   1 
ATOM   3156 C  CA  . ALA B 1 162 ? -5.29119  18.43295  -22.24753 1.000 14.96532 ? 162 ALA B CA  1 
ATOM   3157 C  C   . ALA B 1 162 ? -6.02332  17.59664  -21.20242 1.000 18.38020 ? 162 ALA B C   1 
ATOM   3158 O  O   . ALA B 1 162 ? -5.61761  16.47671  -20.86526 1.000 20.96969 ? 162 ALA B O   1 
ATOM   3159 C  CB  . ALA B 1 162 ? -5.83332  18.09763  -23.63217 1.000 15.20288 ? 162 ALA B CB  1 
ATOM   3160 N  N   . ASP B 1 163 ? -7.13511  18.16088  -20.69491 1.000 15.27027 ? 163 ASP B N   1 
ATOM   3161 C  CA  . ASP B 1 163 ? -8.03768  17.51451  -19.75620 1.000 18.33616 ? 163 ASP B CA  1 
ATOM   3162 C  C   . ASP B 1 163 ? -8.93137  16.46114  -20.40396 1.000 14.76054 ? 163 ASP B C   1 
ATOM   3163 O  O   . ASP B 1 163 ? -9.49205  15.63145  -19.67919 1.000 17.43093 ? 163 ASP B O   1 
ATOM   3164 C  CB  . ASP B 1 163 ? -8.94262  18.56498  -19.09260 1.000 16.72882 ? 163 ASP B CB  1 
ATOM   3165 C  CG  . ASP B 1 163 ? -8.17767  19.48074  -18.16301 1.000 25.67693 ? 163 ASP B CG  1 
ATOM   3166 O  OD1 . ASP B 1 163 ? -7.04928  19.12852  -17.76903 1.000 22.89297 ? 163 ASP B OD1 1 
ATOM   3167 O  OD2 . ASP B 1 163 ? -8.73855  20.52999  -17.81744 1.000 23.27567 ? 163 ASP B OD2 1 
ATOM   3168 N  N   . ALA B 1 164 ? -9.11586  16.51059  -21.72086 1.000 15.25716 ? 164 ALA B N   1 
ATOM   3169 C  CA  . ALA B 1 164 ? -10.02482 15.60586  -22.41496 1.000 17.71793 ? 164 ALA B CA  1 
ATOM   3170 C  C   . ALA B 1 164 ? -9.47113  15.36257  -23.80831 1.000 15.94458 ? 164 ALA B C   1 
ATOM   3171 O  O   . ALA B 1 164 ? -8.74191  16.20302  -24.33419 1.000 12.77395 ? 164 ALA B O   1 
ATOM   3172 C  CB  . ALA B 1 164 ? -11.43823 16.20171  -22.49418 1.000 20.62240 ? 164 ALA B CB  1 
ATOM   3173 N  N   . PRO B 1 165 ? -9.78522  14.23357  -24.42006 1.000 12.79858 ? 165 PRO B N   1 
ATOM   3174 C  CA  . PRO B 1 165 ? -9.28468  13.98544  -25.77199 1.000 11.21448 ? 165 PRO B CA  1 
ATOM   3175 C  C   . PRO B 1 165 ? -10.00719 14.83700  -26.79373 1.000 14.24461 ? 165 PRO B C   1 
ATOM   3176 O  O   . PRO B 1 165 ? -11.15247 15.24760  -26.58936 1.000 19.07340 ? 165 PRO B O   1 
ATOM   3177 C  CB  . PRO B 1 165 ? -9.57847  12.49081  -25.99693 1.000 11.00969 ? 165 PRO B CB  1 
ATOM   3178 C  CG  . PRO B 1 165 ? -10.78267 12.23589  -25.14067 1.000 11.67489 ? 165 PRO B CG  1 
ATOM   3179 C  CD  . PRO B 1 165 ? -10.62869 13.13957  -23.91299 1.000 12.79979 ? 165 PRO B CD  1 
ATOM   3180 N  N   . PHE B 1 166 ? -9.32648  15.10915  -27.89845 1.000 12.38160 ? 166 PHE B N   1 
ATOM   3181 C  CA  . PHE B 1 166 ? -9.96138  15.84557  -28.98250 1.000 12.95495 ? 166 PHE B CA  1 
ATOM   3182 C  C   . PHE B 1 166 ? -10.54961 14.94229  -30.05073 1.000 17.33278 ? 166 PHE B C   1 
ATOM   3183 O  O   . PHE B 1 166 ? -11.33516 15.41040  -30.87986 1.000 17.83081 ? 166 PHE B O   1 
ATOM   3184 C  CB  . PHE B 1 166 ? -8.97795  16.83022  -29.62765 1.000 17.39776 ? 166 PHE B CB  1 
ATOM   3185 C  CG  . PHE B 1 166 ? -7.89715  16.17618  -30.45012 1.000 13.76851 ? 166 PHE B CG  1 
ATOM   3186 C  CD1 . PHE B 1 166 ? -6.74508  15.71729  -29.83965 1.000 15.25589 ? 166 PHE B CD1 1 
ATOM   3187 C  CD2 . PHE B 1 166 ? -8.03707  16.01134  -31.80817 1.000 18.37941 ? 166 PHE B CD2 1 
ATOM   3188 C  CE1 . PHE B 1 166 ? -5.73250  15.10956  -30.58106 1.000 13.54819 ? 166 PHE B CE1 1 
ATOM   3189 C  CE2 . PHE B 1 166 ? -7.04320  15.41355  -32.56101 1.000 22.75659 ? 166 PHE B CE2 1 
ATOM   3190 C  CZ  . PHE B 1 166 ? -5.87940  14.95491  -31.94516 1.000 17.12447 ? 166 PHE B CZ  1 
ATOM   3191 N  N   . TRP B 1 167 ? -10.20492 13.65676  -30.05069 1.000 13.70492 ? 167 TRP B N   1 
ATOM   3192 C  CA  . TRP B 1 167 ? -10.79293 12.70487  -30.98163 1.000 10.79439 ? 167 TRP B CA  1 
ATOM   3193 C  C   . TRP B 1 167 ? -10.93580 11.38160  -30.24941 1.000 13.19827 ? 167 TRP B C   1 
ATOM   3194 O  O   . TRP B 1 167 ? -10.05883 11.00702  -29.46908 1.000 12.17457 ? 167 TRP B O   1 
ATOM   3195 C  CB  . TRP B 1 167 ? -9.93567  12.54659  -32.22588 1.000 13.78650 ? 167 TRP B CB  1 
ATOM   3196 C  CG  . TRP B 1 167 ? -10.48326 11.63386  -33.26185 1.000 16.61812 ? 167 TRP B CG  1 
ATOM   3197 C  CD1 . TRP B 1 167 ? -11.26334 11.98366  -34.32767 1.000 18.00140 ? 167 TRP B CD1 1 
ATOM   3198 C  CD2 . TRP B 1 167 ? -10.26616 10.21743  -33.37034 1.000 14.89833 ? 167 TRP B CD2 1 
ATOM   3199 N  NE1 . TRP B 1 167 ? -11.56249 10.87273  -35.08118 1.000 17.28003 ? 167 TRP B NE1 1 
ATOM   3200 C  CE2 . TRP B 1 167 ? -10.95498 9.77937   -34.52224 1.000 17.31391 ? 167 TRP B CE2 1 
ATOM   3201 C  CE3 . TRP B 1 167 ? -9.55562  9.28283   -32.60815 1.000 16.01116 ? 167 TRP B CE3 1 
ATOM   3202 C  CZ2 . TRP B 1 167 ? -10.97687 8.44426   -34.92305 1.000 14.82990 ? 167 TRP B CZ2 1 
ATOM   3203 C  CZ3 . TRP B 1 167 ? -9.57324  7.96374   -33.00075 1.000 16.09512 ? 167 TRP B CZ3 1 
ATOM   3204 C  CH2 . TRP B 1 167 ? -10.28491 7.54858   -34.15542 1.000 18.36985 ? 167 TRP B CH2 1 
ATOM   3205 N  N   . SER B 1 168 ? -12.04420 10.67446  -30.50725 1.000 12.36951 ? 168 SER B N   1 
ATOM   3206 C  CA  . SER B 1 168 ? -12.26724 9.33886   -29.97004 1.000 9.25627  ? 168 SER B CA  1 
ATOM   3207 C  C   . SER B 1 168 ? -12.89997 8.52735   -31.08880 1.000 16.87948 ? 168 SER B C   1 
ATOM   3208 O  O   . SER B 1 168 ? -13.71615 9.04584   -31.86750 1.000 15.52720 ? 168 SER B O   1 
ATOM   3209 C  CB  . SER B 1 168 ? -13.20311 9.35288   -28.76314 1.000 14.68605 ? 168 SER B CB  1 
ATOM   3210 O  OG  . SER B 1 168 ? -12.68853 10.16567  -27.73527 1.000 29.73611 ? 168 SER B OG  1 
ATOM   3211 N  N   . GLY B 1 169 ? -12.53239 7.25959   -31.16549 1.000 12.05786 ? 169 GLY B N   1 
ATOM   3212 C  CA  . GLY B 1 169 ? -13.16372 6.37733   -32.12722 1.000 9.58291  ? 169 GLY B CA  1 
ATOM   3213 C  C   . GLY B 1 169 ? -12.78069 4.96272   -31.77937 1.000 8.50341  ? 169 GLY B C   1 
ATOM   3214 O  O   . GLY B 1 169 ? -11.64995 4.68085   -31.34262 1.000 8.47751  ? 169 GLY B O   1 
ATOM   3215 N  N   . THR B 1 170 ? -13.70220 4.05039   -31.94207 1.000 9.86092  ? 170 THR B N   1 
ATOM   3216 C  CA  . THR B 1 170 ? -13.41632 2.64101   -31.75271 1.000 9.36491  ? 170 THR B CA  1 
ATOM   3217 C  C   . THR B 1 170 ? -12.97324 2.05277   -33.08171 1.000 9.12246  ? 170 THR B C   1 
ATOM   3218 O  O   . THR B 1 170 ? -13.77580 1.94995   -34.02275 1.000 10.84023 ? 170 THR B O   1 
ATOM   3219 C  CB  . THR B 1 170 ? -14.63800 1.91268   -31.24595 1.000 10.76491 ? 170 THR B CB  1 
ATOM   3220 O  OG1 . THR B 1 170 ? -15.09565 2.55831   -30.05318 1.000 10.90391 ? 170 THR B OG1 1 
ATOM   3221 C  CG2 . THR B 1 170 ? -14.29660 0.45270   -30.93974 1.000 9.53882  ? 170 THR B CG2 1 
ATOM   3222 N  N   . LEU B 1 171 ? -11.70595 1.66436   -33.16429 1.000 7.92727  ? 171 LEU B N   1 
ATOM   3223 C  CA  . LEU B 1 171 ? -11.19856 1.07036   -34.39574 1.000 6.36786  ? 171 LEU B CA  1 
ATOM   3224 C  C   . LEU B 1 171 ? -11.71296 -0.34927  -34.49276 1.000 7.38916  ? 171 LEU B C   1 
ATOM   3225 O  O   . LEU B 1 171 ? -11.68265 -1.09924  -33.52035 1.000 9.24444  ? 171 LEU B O   1 
ATOM   3226 C  CB  . LEU B 1 171 ? -9.67130  1.08662   -34.42058 1.000 9.17808  ? 171 LEU B CB  1 
ATOM   3227 C  CG  . LEU B 1 171 ? -9.11316  2.50394   -34.32286 1.000 12.81882 ? 171 LEU B CG  1 
ATOM   3228 C  CD1 . LEU B 1 171 ? -7.62256  2.41155   -34.05201 1.000 12.57049 ? 171 LEU B CD1 1 
ATOM   3229 C  CD2 . LEU B 1 171 ? -9.35657  3.18996   -35.64987 1.000 16.83484 ? 171 LEU B CD2 1 
ATOM   3230 N  N   . GLU B 1 172 ? -12.22057 -0.69797  -35.66149 1.000 9.15867  ? 172 GLU B N   1 
ATOM   3231 C  CA  . GLU B 1 172 ? -12.75486 -2.03108  -35.90875 1.000 8.91845  ? 172 GLU B CA  1 
ATOM   3232 C  C   . GLU B 1 172 ? -11.77096 -2.86537  -36.69739 1.000 7.58987  ? 172 GLU B C   1 
ATOM   3233 O  O   . GLU B 1 172 ? -10.81928 -2.36344  -37.27492 1.000 8.23115  ? 172 GLU B O   1 
ATOM   3234 C  CB  . GLU B 1 172 ? -14.08126 -1.93549  -36.66118 1.000 8.35528  ? 172 GLU B CB  1 
ATOM   3235 C  CG  . GLU B 1 172 ? -15.12476 -1.06974  -35.92676 1.000 9.00435  ? 172 GLU B CG  1 
ATOM   3236 C  CD  . GLU B 1 172 ? -15.40720 -1.47596  -34.50381 1.000 11.28006 ? 172 GLU B CD  1 
ATOM   3237 O  OE1 . GLU B 1 172 ? -15.07043 -2.61177  -34.07460 1.000 11.88840 ? 172 GLU B OE1 1 
ATOM   3238 O  OE2 . GLU B 1 172 ? -16.01587 -0.64788  -33.77660 1.000 13.45858 ? 172 GLU B OE2 1 
ATOM   3239 N  N   . ALA B 1 173 ? -12.02794 -4.18032  -36.72885 1.000 9.21258  ? 173 ALA B N   1 
ATOM   3240 C  CA  . ALA B 1 173 ? -11.19875 -5.05784  -37.53932 1.000 7.37899  ? 173 ALA B CA  1 
ATOM   3241 C  C   . ALA B 1 173 ? -11.12244 -4.55070  -38.97081 1.000 10.21764 ? 173 ALA B C   1 
ATOM   3242 O  O   . ALA B 1 173 ? -12.14218 -4.17292  -39.57118 1.000 12.61277 ? 173 ALA B O   1 
ATOM   3243 C  CB  . ALA B 1 173 ? -11.77202 -6.48481  -37.50422 1.000 10.67876 ? 173 ALA B CB  1 
ATOM   3244 N  N   . GLY B 1 174 ? -9.90473  -4.48280  -39.49768 1.000 9.52279  ? 174 GLY B N   1 
ATOM   3245 C  CA  . GLY B 1 174 ? -9.65742  -3.96181  -40.82636 1.000 9.19549  ? 174 GLY B CA  1 
ATOM   3246 C  C   . GLY B 1 174 ? -9.34522  -2.47706  -40.88748 1.000 13.47724 ? 174 GLY B C   1 
ATOM   3247 O  O   . GLY B 1 174 ? -9.22862  -1.94238  -41.99571 1.000 13.29698 ? 174 GLY B O   1 
ATOM   3248 N  N   . GLN B 1 175 ? -9.24310  -1.79520  -39.74341 1.000 8.71444  ? 175 GLN B N   1 
ATOM   3249 C  CA  . GLN B 1 175 ? -8.84628  -0.39106  -39.67038 1.000 6.89462  ? 175 GLN B CA  1 
ATOM   3250 C  C   . GLN B 1 175 ? -7.50622  -0.24032  -38.97900 1.000 8.29148  ? 175 GLN B C   1 
ATOM   3251 O  O   . GLN B 1 175 ? -7.12107  -1.06736  -38.15444 1.000 9.21947  ? 175 GLN B O   1 
ATOM   3252 C  CB  . GLN B 1 175 ? -9.85233  0.46042   -38.89016 1.000 8.14597  ? 175 GLN B CB  1 
ATOM   3253 C  CG  . GLN B 1 175 ? -11.24178 0.52094   -39.52750 1.000 13.31100 ? 175 GLN B CG  1 
ATOM   3254 C  CD  . GLN B 1 175 ? -12.12492 1.50767   -38.83419 1.000 14.96143 ? 175 GLN B CD  1 
ATOM   3255 O  OE1 . GLN B 1 175 ? -12.59149 1.28401   -37.69505 1.000 13.58442 ? 175 GLN B OE1 1 
ATOM   3256 N  NE2 . GLN B 1 175 ? -12.37853 2.64291   -39.51435 1.000 19.65726 ? 175 GLN B NE2 1 
ATOM   3257 N  N   . ALA B 1 176 ? -6.82373  0.85494   -39.29284 1.000 7.41853  ? 176 ALA B N   1 
ATOM   3258 C  CA  . ALA B 1 176 ? -5.60405  1.19993   -38.56755 1.000 8.59833  ? 176 ALA B CA  1 
ATOM   3259 C  C   . ALA B 1 176 ? -5.56658  2.69395   -38.33634 1.000 10.74271 ? 176 ALA B C   1 
ATOM   3260 O  O   . ALA B 1 176 ? -6.08161  3.45829   -39.15158 1.000 9.64961  ? 176 ALA B O   1 
ATOM   3261 C  CB  . ALA B 1 176 ? -4.35529  0.79491   -39.33874 1.000 8.40731  ? 176 ALA B CB  1 
ATOM   3262 N  N   . VAL B 1 177 ? -4.94098  3.11697   -37.22886 1.000 8.15797  ? 177 VAL B N   1 
ATOM   3263 C  CA  . VAL B 1 177 ? -4.66200  4.53385   -37.03367 1.000 8.80253  ? 177 VAL B CA  1 
ATOM   3264 C  C   . VAL B 1 177 ? -3.16186  4.75619   -37.12178 1.000 9.17834  ? 177 VAL B C   1 
ATOM   3265 O  O   . VAL B 1 177 ? -2.36452  3.94794   -36.62501 1.000 8.43878  ? 177 VAL B O   1 
ATOM   3266 C  CB  . VAL B 1 177 ? -5.24235  5.03282   -35.69769 1.000 9.11104  ? 177 VAL B CB  1 
ATOM   3267 C  CG1 . VAL B 1 177 ? -4.56953  4.36894   -34.47841 1.000 13.14531 ? 177 VAL B CG1 1 
ATOM   3268 C  CG2 . VAL B 1 177 ? -5.09290  6.55952   -35.58368 1.000 10.92614 ? 177 VAL B CG2 1 
ATOM   3269 N  N   A LEU B 1 178 ? -2.76955  5.82772   -37.80407 0.393 8.41748  ? 178 LEU B N   1 
ATOM   3270 N  N   B LEU B 1 178 ? -2.78121  5.84127   -37.79580 0.607 8.37877  ? 178 LEU B N   1 
ATOM   3271 C  CA  A LEU B 1 178 ? -1.38125  6.25880   -37.86727 0.393 8.12683  ? 178 LEU B CA  1 
ATOM   3272 C  CA  B LEU B 1 178 ? -1.40873  6.31366   -37.84817 0.607 8.08974  ? 178 LEU B CA  1 
ATOM   3273 C  C   A LEU B 1 178 ? -1.28298  7.59773   -37.16556 0.393 9.65124  ? 178 LEU B C   1 
ATOM   3274 C  C   B LEU B 1 178 ? -1.31691  7.56944   -36.98908 0.607 9.72936  ? 178 LEU B C   1 
ATOM   3275 O  O   A LEU B 1 178 ? -2.03656  8.51380   -37.49634 0.393 8.61020  ? 178 LEU B O   1 
ATOM   3276 O  O   B LEU B 1 178 ? -2.21593  8.41265   -37.02138 0.607 9.61194  ? 178 LEU B O   1 
ATOM   3277 C  CB  A LEU B 1 178 ? -0.91385  6.41420   -39.31167 0.393 9.21263  ? 178 LEU B CB  1 
ATOM   3278 C  CB  B LEU B 1 178 ? -0.98244  6.62116   -39.29531 0.607 8.90486  ? 178 LEU B CB  1 
ATOM   3279 C  CG  A LEU B 1 178 ? -1.32171  5.28509   -40.23508 0.393 14.19996 ? 178 LEU B CG  1 
ATOM   3280 C  CG  B LEU B 1 178 ? -0.79969  5.51295   -40.34412 0.607 14.07202 ? 178 LEU B CG  1 
ATOM   3281 C  CD1 A LEU B 1 178 ? -1.37561  5.83044   -41.63341 0.393 11.30167 ? 178 LEU B CD1 1 
ATOM   3282 C  CD1 B LEU B 1 178 ? 0.37786   4.61887   -40.01844 0.607 14.52442 ? 178 LEU B CD1 1 
ATOM   3283 C  CD2 A LEU B 1 178 ? -0.31583  4.18573   -40.14279 0.393 12.29806 ? 178 LEU B CD2 1 
ATOM   3284 C  CD2 B LEU B 1 178 ? -2.07019  4.66919   -40.56844 0.607 13.79601 ? 178 LEU B CD2 1 
ATOM   3285 N  N   A LEU B 1 179 ? -0.36279  7.71732   -36.21098 0.393 8.12398  ? 179 LEU B N   1 
ATOM   3286 N  N   B LEU B 1 179 ? -0.25299  7.67579   -36.19194 0.607 8.09226  ? 179 LEU B N   1 
ATOM   3287 C  CA  A LEU B 1 179 ? -0.30394  8.91210   -35.38301 0.393 9.01943  ? 179 LEU B CA  1 
ATOM   3288 C  CA  B LEU B 1 179 ? -0.12347  8.73079   -35.19113 0.607 9.18543  ? 179 LEU B CA  1 
ATOM   3289 C  C   A LEU B 1 179 ? 1.11300   9.45313   -35.24916 0.393 8.42210  ? 179 LEU B C   1 
ATOM   3290 C  C   B LEU B 1 179 ? 1.21945   9.43994   -35.28905 0.607 8.34615  ? 179 LEU B C   1 
ATOM   3291 O  O   A LEU B 1 179 ? 2.09839   8.70754   -35.21040 0.393 8.19972  ? 179 LEU B O   1 
ATOM   3292 O  O   B LEU B 1 179 ? 2.26766   8.79346   -35.40750 0.607 8.13701  ? 179 LEU B O   1 
ATOM   3293 C  CB  A LEU B 1 179 ? -0.89261  8.64779   -33.98486 0.393 10.17489 ? 179 LEU B CB  1 
ATOM   3294 C  CB  B LEU B 1 179 ? -0.25768  8.17011   -33.75264 0.607 10.08181 ? 179 LEU B CB  1 
ATOM   3295 C  CG  A LEU B 1 179 ? -0.26104  7.51661   -33.16901 0.393 10.33348 ? 179 LEU B CG  1 
ATOM   3296 C  CG  B LEU B 1 179 ? -1.56327  7.47421   -33.36982 0.607 10.45425 ? 179 LEU B CG  1 
ATOM   3297 C  CD1 A LEU B 1 179 ? 0.71943   8.03695   -32.16017 0.393 10.61615 ? 179 LEU B CD1 1 
ATOM   3298 C  CD1 B LEU B 1 179 ? -1.50948  7.10901   -31.88254 0.607 10.80679 ? 179 LEU B CD1 1 
ATOM   3299 C  CD2 A LEU B 1 179 ? -1.34143  6.67820   -32.46993 0.393 12.30924 ? 179 LEU B CD2 1 
ATOM   3300 C  CD2 B LEU B 1 179 ? -2.71113  8.40937   -33.64553 0.607 8.60309  ? 179 LEU B CD2 1 
ATOM   3301 N  N   . ASP B 1 180 ? 1.17760   10.77496  -35.17228 1.000 9.60233  ? 180 ASP B N   1 
ATOM   3302 C  CA  . ASP B 1 180 ? 2.35018   11.54690  -34.77423 1.000 9.81435  ? 180 ASP B CA  1 
ATOM   3303 C  C   . ASP B 1 180 ? 2.52022   11.35741  -33.27113 1.000 13.26152 ? 180 ASP B C   1 
ATOM   3304 O  O   . ASP B 1 180 ? 1.79018   11.95292  -32.46846 1.000 14.27918 ? 180 ASP B O   1 
ATOM   3305 C  CB  . ASP B 1 180 ? 2.13348   13.01520  -35.15042 1.000 13.26577 ? 180 ASP B CB  1 
ATOM   3306 C  CG  . ASP B 1 180 ? 3.11902   13.95611  -34.46069 1.000 15.08896 ? 180 ASP B CG  1 
ATOM   3307 O  OD1 . ASP B 1 180 ? 4.14292   13.49277  -33.91576 1.000 15.26129 ? 180 ASP B OD1 1 
ATOM   3308 O  OD2 . ASP B 1 180 ? 2.86509   15.19982  -34.46629 1.000 21.70120 ? 180 ASP B OD2 1 
ATOM   3309 N  N   . ASP B 1 181 ? 3.45945   10.49252  -32.88313 1.000 8.97213  ? 181 ASP B N   1 
ATOM   3310 C  CA  . ASP B 1 181 ? 3.59040   10.06630  -31.49870 1.000 8.11096  ? 181 ASP B CA  1 
ATOM   3311 C  C   . ASP B 1 181 ? 4.30639   11.08636  -30.63688 1.000 11.91236 ? 181 ASP B C   1 
ATOM   3312 O  O   . ASP B 1 181 ? 4.35051   10.93691  -29.40997 1.000 11.90054 ? 181 ASP B O   1 
ATOM   3313 C  CB  . ASP B 1 181 ? 4.33682   8.72854   -31.49633 1.000 11.45118 ? 181 ASP B CB  1 
ATOM   3314 C  CG  . ASP B 1 181 ? 4.38755   8.03839   -30.11786 1.000 12.00326 ? 181 ASP B CG  1 
ATOM   3315 O  OD1 . ASP B 1 181 ? 3.36064   7.91005   -29.39472 1.000 11.76018 ? 181 ASP B OD1 1 
ATOM   3316 O  OD2 . ASP B 1 181 ? 5.47929   7.53931   -29.79974 1.000 15.76756 ? 181 ASP B OD2 1 
ATOM   3317 N  N   . ARG B 1 182 ? 4.87652   12.10685  -31.26022 1.000 11.76586 ? 182 ARG B N   1 
ATOM   3318 C  CA  . ARG B 1 182 ? 5.44833   13.22668  -30.53349 1.000 14.05330 ? 182 ARG B CA  1 
ATOM   3319 C  C   . ARG B 1 182 ? 4.43198   14.32019  -30.26027 1.000 13.41711 ? 182 ARG B C   1 
ATOM   3320 O  O   . ARG B 1 182 ? 4.35850   14.80556  -29.12354 1.000 16.16847 ? 182 ARG B O   1 
ATOM   3321 C  CB  . ARG B 1 182 ? 6.64373   13.76848  -31.31709 1.000 15.25446 ? 182 ARG B CB  1 
ATOM   3322 C  CG  . ARG B 1 182 ? 7.73900   12.76479  -31.34988 1.000 13.23454 ? 182 ARG B CG  1 
ATOM   3323 C  CD  . ARG B 1 182 ? 8.89398   13.17348  -32.22918 1.000 14.88184 ? 182 ARG B CD  1 
ATOM   3324 N  NE  . ARG B 1 182 ? 9.96532   12.19214  -32.09472 1.000 15.57670 ? 182 ARG B NE  1 
ATOM   3325 C  CZ  . ARG B 1 182 ? 11.08496  12.21516  -32.80022 1.000 23.88669 ? 182 ARG B CZ  1 
ATOM   3326 N  NH1 . ARG B 1 182 ? 11.28017  13.11930  -33.74492 1.000 22.10425 ? 182 ARG B NH1 1 
ATOM   3327 N  NH2 . ARG B 1 182 ? 12.04096  11.32878  -32.52766 1.000 21.96603 ? 182 ARG B NH2 1 
ATOM   3328 N  N   . GLY B 1 183 ? 3.63416   14.70012  -31.26400 1.000 11.97152 ? 183 GLY B N   1 
ATOM   3329 C  CA  . GLY B 1 183 ? 2.68638   15.78443  -31.11059 1.000 10.84253 ? 183 GLY B CA  1 
ATOM   3330 C  C   . GLY B 1 183 ? 1.40539   15.42946  -30.39742 1.000 14.53025 ? 183 GLY B C   1 
ATOM   3331 O  O   . GLY B 1 183 ? 0.72064   16.33089  -29.90670 1.000 16.32920 ? 183 GLY B O   1 
ATOM   3332 N  N   . LEU B 1 184 ? 1.04059   14.15342  -30.37815 1.000 11.88041 ? 184 LEU B N   1 
ATOM   3333 C  CA  . LEU B 1 184 ? -0.18934  13.67644  -29.75534 1.000 13.26216 ? 184 LEU B CA  1 
ATOM   3334 C  C   . LEU B 1 184 ? 0.16398   12.63420  -28.71397 1.000 13.36269 ? 184 LEU B C   1 
ATOM   3335 O  O   . LEU B 1 184 ? 1.20061   11.98291  -28.81143 1.000 13.11698 ? 184 LEU B O   1 
ATOM   3336 C  CB  . LEU B 1 184 ? -1.12977  12.99603  -30.76047 1.000 14.67385 ? 184 LEU B CB  1 
ATOM   3337 C  CG  . LEU B 1 184 ? -1.51435  13.75700  -32.00778 1.000 19.92172 ? 184 LEU B CG  1 
ATOM   3338 C  CD1 . LEU B 1 184 ? -2.46235  12.91436  -32.83913 1.000 15.67018 ? 184 LEU B CD1 1 
ATOM   3339 C  CD2 . LEU B 1 184 ? -2.17301  15.03557  -31.57023 1.000 21.18420 ? 184 LEU B CD2 1 
ATOM   3340 N  N   . ALA B 1 185 ? -0.69979  12.49536  -27.72462 1.000 8.14469  ? 185 ALA B N   1 
ATOM   3341 C  CA  . ALA B 1 185 ? -0.67702  11.38367  -26.78765 1.000 8.08238  ? 185 ALA B CA  1 
ATOM   3342 C  C   . ALA B 1 185 ? -1.93656  10.55533  -27.00707 1.000 9.03131  ? 185 ALA B C   1 
ATOM   3343 O  O   . ALA B 1 185 ? -2.89228  11.00352  -27.64955 1.000 9.36958  ? 185 ALA B O   1 
ATOM   3344 C  CB  . ALA B 1 185 ? -0.58677  11.87631  -25.33510 1.000 11.39929 ? 185 ALA B CB  1 
ATOM   3345 N  N   . HIS B 1 186 ? -1.93053  9.32695   -26.49672 1.000 7.63779  ? 186 HIS B N   1 
ATOM   3346 C  CA  . HIS B 1 186 ? -3.07528  8.45816   -26.74096 1.000 6.91283  ? 186 HIS B CA  1 
ATOM   3347 C  C   . HIS B 1 186 ? -3.35054  7.56207   -25.54496 1.000 5.71392  ? 186 HIS B C   1 
ATOM   3348 O  O   . HIS B 1 186 ? -2.46858  7.25778   -24.72620 1.000 5.87220  ? 186 HIS B O   1 
ATOM   3349 C  CB  . HIS B 1 186 ? -2.88603  7.59562   -28.01359 1.000 8.26069  ? 186 HIS B CB  1 
ATOM   3350 C  CG  . HIS B 1 186 ? -1.65482  6.74118   -28.00469 1.000 7.53905  ? 186 HIS B CG  1 
ATOM   3351 N  ND1 . HIS B 1 186 ? -0.39879  7.21415   -28.33607 1.000 10.65346 ? 186 HIS B ND1 1 
ATOM   3352 C  CD2 . HIS B 1 186 ? -1.49261  5.43336   -27.68560 1.000 8.79935  ? 186 HIS B CD2 1 
ATOM   3353 C  CE1 . HIS B 1 186 ? 0.48381   6.23159   -28.24278 1.000 12.28447 ? 186 HIS B CE1 1 
ATOM   3354 N  NE2 . HIS B 1 186 ? -0.15505  5.14275   -27.85249 1.000 11.12416 ? 186 HIS B NE2 1 
ATOM   3355 N  N   . ASP B 1 187 ? -4.60822  7.12488   -25.46399 1.000 6.89453  ? 187 ASP B N   1 
ATOM   3356 C  CA  . ASP B 1 187 ? -4.92421  5.96846   -24.62823 1.000 8.31926  ? 187 ASP B CA  1 
ATOM   3357 C  C   . ASP B 1 187 ? -6.07662  5.23275   -25.28471 1.000 8.45319  ? 187 ASP B C   1 
ATOM   3358 O  O   . ASP B 1 187 ? -6.61075  5.66540   -26.30068 1.000 7.18243  ? 187 ASP B O   1 
ATOM   3359 C  CB  . ASP B 1 187 ? -5.21542  6.33847   -23.15427 1.000 7.42315  ? 187 ASP B CB  1 
ATOM   3360 C  CG  . ASP B 1 187 ? -6.57359  6.97081   -22.91821 1.000 9.22721  ? 187 ASP B CG  1 
ATOM   3361 O  OD1 . ASP B 1 187 ? -7.17693  7.55867   -23.83705 1.000 10.56912 ? 187 ASP B OD1 1 
ATOM   3362 O  OD2 . ASP B 1 187 ? -7.00666  6.82564   -21.73427 1.000 11.80799 ? 187 ASP B OD2 1 
ATOM   3363 N  N   . VAL B 1 188 ? -6.42746  4.07900   -24.71254 1.000 5.76584  ? 188 VAL B N   1 
ATOM   3364 C  CA  . VAL B 1 188 ? -7.50571  3.25810   -25.24901 1.000 7.92483  ? 188 VAL B CA  1 
ATOM   3365 C  C   . VAL B 1 188 ? -8.31174  2.72678   -24.08416 1.000 6.64901  ? 188 VAL B C   1 
ATOM   3366 O  O   . VAL B 1 188 ? -7.74770  2.25033   -23.09264 1.000 9.15624  ? 188 VAL B O   1 
ATOM   3367 C  CB  . VAL B 1 188 ? -7.01659  2.09965   -26.13918 1.000 7.45374  ? 188 VAL B CB  1 
ATOM   3368 C  CG1 . VAL B 1 188 ? -8.18307  1.55166   -27.00435 1.000 9.73901  ? 188 VAL B CG1 1 
ATOM   3369 C  CG2 . VAL B 1 188 ? -5.95806  2.54550   -27.09986 1.000 8.97563  ? 188 VAL B CG2 1 
ATOM   3370 N  N   . THR B 1 189 ? -9.62925  2.81889   -24.18744 1.000 6.36991  ? 189 THR B N   1 
ATOM   3371 C  CA  . THR B 1 189 ? -10.42500 2.27647   -23.08710 1.000 7.46509  ? 189 THR B CA  1 
ATOM   3372 C  C   . THR B 1 189 ? -10.35251 0.74775   -23.08998 1.000 9.54275  ? 189 THR B C   1 
ATOM   3373 O  O   . THR B 1 189 ? -10.11166 0.11790   -24.11827 1.000 9.21963  ? 189 THR B O   1 
ATOM   3374 C  CB  . THR B 1 189 ? -11.88905 2.73144   -23.15880 1.000 7.89499  ? 189 THR B CB  1 
ATOM   3375 O  OG1 . THR B 1 189 ? -12.54927 2.20247   -24.33601 1.000 10.00606 ? 189 THR B OG1 1 
ATOM   3376 C  CG2 . THR B 1 189 ? -11.99715 4.25470   -23.21636 1.000 9.86732  ? 189 THR B CG2 1 
ATOM   3377 N  N   . ASP B 1 190 ? -10.61366 0.14844   -21.92639 1.000 8.51796  ? 190 ASP B N   1 
ATOM   3378 C  CA  . ASP B 1 190 ? -10.49968 -1.30022  -21.78938 1.000 8.36793  ? 190 ASP B CA  1 
ATOM   3379 C  C   . ASP B 1 190 ? -11.41283 -2.03013  -22.77479 1.000 7.69279  ? 190 ASP B C   1 
ATOM   3380 O  O   . ASP B 1 190 ? -12.50844 -1.56319  -23.11617 1.000 11.36942 ? 190 ASP B O   1 
ATOM   3381 C  CB  . ASP B 1 190 ? -10.91681 -1.77850  -20.38941 1.000 11.29005 ? 190 ASP B CB  1 
ATOM   3382 C  CG  . ASP B 1 190 ? -10.01224 -1.31273  -19.28035 1.000 16.49488 ? 190 ASP B CG  1 
ATOM   3383 O  OD1 . ASP B 1 190 ? -8.93038  -0.77587  -19.52922 1.000 16.49610 ? 190 ASP B OD1 1 
ATOM   3384 O  OD2 . ASP B 1 190 ? -10.40058 -1.52000  -18.09816 1.000 21.82623 ? 190 ASP B OD2 1 
ATOM   3385 N  N   . VAL B 1 191 ? -10.94288 -3.21291  -23.18730 1.000 8.54723  ? 191 VAL B N   1 
ATOM   3386 C  CA  . VAL B 1 191 ? -11.75830 -4.18996  -23.91238 1.000 9.34325  ? 191 VAL B CA  1 
ATOM   3387 C  C   . VAL B 1 191 ? -12.76141 -4.78870  -22.94090 1.000 8.49202  ? 191 VAL B C   1 
ATOM   3388 O  O   . VAL B 1 191 ? -12.39108 -5.21781  -21.84376 1.000 9.87298  ? 191 VAL B O   1 
ATOM   3389 C  CB  . VAL B 1 191 ? -10.85129 -5.28623  -24.50621 1.000 10.06279 ? 191 VAL B CB  1 
ATOM   3390 C  CG1 . VAL B 1 191 ? -11.67295 -6.28258  -25.29928 1.000 14.45773 ? 191 VAL B CG1 1 
ATOM   3391 C  CG2 . VAL B 1 191 ? -9.75857  -4.69038  -25.36229 1.000 12.52544 ? 191 VAL B CG2 1 
ATOM   3392 N  N   . LEU B 1 192 ? -14.03593 -4.83046  -23.33071 1.000 8.77675  ? 192 LEU B N   1 
ATOM   3393 C  CA  . LEU B 1 192 ? -15.06920 -5.44302  -22.50439 1.000 10.11062 ? 192 LEU B CA  1 
ATOM   3394 C  C   . LEU B 1 192 ? -15.66245 -6.67172  -23.18075 1.000 11.20468 ? 192 LEU B C   1 
ATOM   3395 O  O   . LEU B 1 192 ? -15.77576 -6.73224  -24.40647 1.000 10.70002 ? 192 LEU B O   1 
ATOM   3396 C  CB  . LEU B 1 192 ? -16.21082 -4.45312  -22.23128 1.000 11.62152 ? 192 LEU B CB  1 
ATOM   3397 C  CG  . LEU B 1 192 ? -15.75201 -3.12269  -21.66638 1.000 13.16354 ? 192 LEU B CG  1 
ATOM   3398 C  CD1 . LEU B 1 192 ? -16.94790 -2.18954  -21.62699 1.000 19.88885 ? 192 LEU B CD1 1 
ATOM   3399 C  CD2 . LEU B 1 192 ? -15.12923 -3.26457  -20.31221 1.000 16.63891 ? 192 LEU B CD2 1 
ATOM   3400 N  N   . SER B 1 193 ? -16.09370 -7.63475  -22.37292 1.000 10.19353 ? 193 SER B N   1 
ATOM   3401 C  CA  . SER B 1 193 ? -16.88877 -8.73382  -22.91222 1.000 9.32239  ? 193 SER B CA  1 
ATOM   3402 C  C   . SER B 1 193 ? -18.20557 -8.20010  -23.45489 1.000 11.97716 ? 193 SER B C   1 
ATOM   3403 O  O   . SER B 1 193 ? -18.87220 -7.38967  -22.80703 1.000 15.44447 ? 193 SER B O   1 
ATOM   3404 C  CB  . SER B 1 193 ? -17.14673 -9.77114  -21.82513 1.000 12.51512 ? 193 SER B CB  1 
ATOM   3405 O  OG  . SER B 1 193 ? -18.14292 -10.66884 -22.27388 1.000 15.07723 ? 193 SER B OG  1 
ATOM   3406 N  N   . ALA B 1 194 ? -18.56451 -8.61818  -24.67723 1.000 12.52271 ? 194 ALA B N   1 
ATOM   3407 C  CA  . ALA B 1 194 ? -19.78498 -8.07755  -25.26307 1.000 12.63731 ? 194 ALA B CA  1 
ATOM   3408 C  C   . ALA B 1 194 ? -21.03489 -8.67370  -24.62855 1.000 17.62183 ? 194 ALA B C   1 
ATOM   3409 O  O   . ALA B 1 194 ? -22.09023 -8.02356  -24.62575 1.000 19.95242 ? 194 ALA B O   1 
ATOM   3410 C  CB  . ALA B 1 194 ? -19.79233 -8.30502  -26.77595 1.000 10.90188 ? 194 ALA B CB  1 
ATOM   3411 N  N   . ASP B 1 195 ? -20.93352 -9.88088  -24.05763 1.000 14.57104 ? 195 ASP B N   1 
ATOM   3412 C  CA  . ASP B 1 195 ? -22.12569 -10.59348 -23.60954 1.000 19.50042 ? 195 ASP B CA  1 
ATOM   3413 C  C   . ASP B 1 195 ? -21.94345 -11.33212 -22.29436 1.000 22.05198 ? 195 ASP B C   1 
ATOM   3414 O  O   . ASP B 1 195 ? -22.84478 -12.08583 -21.89704 1.000 24.61935 ? 195 ASP B O   1 
ATOM   3415 C  CB  . ASP B 1 195 ? -22.59971 -11.59955 -24.68559 1.000 22.83548 ? 195 ASP B CB  1 
ATOM   3416 C  CG  . ASP B 1 195 ? -21.67414 -12.80153 -24.84447 1.000 22.03674 ? 195 ASP B CG  1 
ATOM   3417 O  OD1 . ASP B 1 195 ? -20.60019 -12.87168 -24.20583 1.000 19.46103 ? 195 ASP B OD1 1 
ATOM   3418 O  OD2 . ASP B 1 195 ? -22.01997 -13.71347 -25.62992 1.000 28.08285 ? 195 ASP B OD2 1 
ATOM   3419 N  N   . GLY B 1 196 ? -20.81541 -11.16733 -21.61326 1.000 20.84798 ? 196 GLY B N   1 
ATOM   3420 C  CA  . GLY B 1 196 ? -20.53545 -11.88637 -20.40194 1.000 17.32045 ? 196 GLY B CA  1 
ATOM   3421 C  C   . GLY B 1 196 ? -19.56420 -13.02911 -20.57518 1.000 17.68537 ? 196 GLY B C   1 
ATOM   3422 O  O   . GLY B 1 196 ? -18.99564 -13.49323 -19.58145 1.000 20.86121 ? 196 GLY B O   1 
ATOM   3423 N  N   . GLY B 1 197 ? -19.36046 -13.49020 -21.81046 1.000 14.44179 ? 197 GLY B N   1 
ATOM   3424 C  CA  . GLY B 1 197 ? -18.46637 -14.58025 -22.09248 1.000 15.19870 ? 197 GLY B CA  1 
ATOM   3425 C  C   . GLY B 1 197 ? -17.12673 -14.08726 -22.60246 1.000 14.32738 ? 197 GLY B C   1 
ATOM   3426 O  O   . GLY B 1 197 ? -16.86464 -12.88453 -22.68903 1.000 15.57350 ? 197 GLY B O   1 
ATOM   3427 N  N   . PRO B 1 198 ? -16.25181 -15.02072 -22.93295 1.000 13.77709 ? 198 PRO B N   1 
ATOM   3428 C  CA  . PRO B 1 198 ? -14.91400 -14.64872 -23.41928 1.000 12.25583 ? 198 PRO B CA  1 
ATOM   3429 C  C   . PRO B 1 198 ? -14.95176 -13.93281 -24.77245 1.000 11.61405 ? 198 PRO B C   1 
ATOM   3430 O  O   . PRO B 1 198 ? -15.75284 -14.25416 -25.66244 1.000 13.18174 ? 198 PRO B O   1 
ATOM   3431 C  CB  . PRO B 1 198 ? -14.17877 -15.98814 -23.51456 1.000 16.29336 ? 198 PRO B CB  1 
ATOM   3432 C  CG  . PRO B 1 198 ? -15.16041 -17.04747 -23.11381 1.000 23.86797 ? 198 PRO B CG  1 
ATOM   3433 C  CD  . PRO B 1 198 ? -16.31477 -16.41346 -22.45068 1.000 17.80010 ? 198 PRO B CD  1 
ATOM   3434 N  N   . GLY B 1 199 ? -14.05500 -12.94581 -24.91870 1.000 8.97134  ? 199 GLY B N   1 
ATOM   3435 C  CA  . GLY B 1 199 ? -13.86976 -12.24217 -26.17583 1.000 8.12075  ? 199 GLY B CA  1 
ATOM   3436 C  C   . GLY B 1 199 ? -12.42328 -11.80146 -26.26852 1.000 10.10299 ? 199 GLY B C   1 
ATOM   3437 O  O   . GLY B 1 199 ? -11.67868 -11.86845 -25.28779 1.000 8.07828  ? 199 GLY B O   1 
ATOM   3438 N  N   . HIS B 1 200 ? -12.01708 -11.37604 -27.46058 1.000 7.64418  ? 200 HIS B N   1 
ATOM   3439 C  CA  . HIS B 1 200 ? -10.62409 -10.95032 -27.63792 1.000 8.57963  ? 200 HIS B CA  1 
ATOM   3440 C  C   . HIS B 1 200 ? -10.50322 -9.92435  -28.75696 1.000 8.65778  ? 200 HIS B C   1 
ATOM   3441 O  O   . HIS B 1 200 ? -11.36194 -9.80739  -29.63288 1.000 6.86681  ? 200 HIS B O   1 
ATOM   3442 C  CB  . HIS B 1 200 ? -9.69673  -12.15510 -27.88943 1.000 9.11277  ? 200 HIS B CB  1 
ATOM   3443 C  CG  . HIS B 1 200 ? -9.95412  -12.88425 -29.17140 1.000 10.02788 ? 200 HIS B CG  1 
ATOM   3444 N  ND1 . HIS B 1 200 ? -10.77531 -13.99313 -29.22898 1.000 16.24426 ? 200 HIS B ND1 1 
ATOM   3445 C  CD2 . HIS B 1 200 ? -9.48898  -12.68881 -30.42269 1.000 14.32420 ? 200 HIS B CD2 1 
ATOM   3446 C  CE1 . HIS B 1 200 ? -10.81332 -14.44067 -30.47727 1.000 14.39443 ? 200 HIS B CE1 1 
ATOM   3447 N  NE2 . HIS B 1 200 ? -10.05341 -13.66045 -31.22275 1.000 19.08130 ? 200 HIS B NE2 1 
ATOM   3448 N  N   . ARG B 1 201 ? -9.39232  -9.19195  -28.70546 1.000 5.40921  ? 201 ARG B N   1 
ATOM   3449 C  CA  . ARG B 1 201 ? -9.07143  -8.11428  -29.63492 1.000 6.43688  ? 201 ARG B CA  1 
ATOM   3450 C  C   . ARG B 1 201 ? -7.62939  -8.33892  -30.06633 1.000 5.86834  ? 201 ARG B C   1 
ATOM   3451 O  O   . ARG B 1 201 ? -6.72397  -8.29562  -29.22731 1.000 5.54069  ? 201 ARG B O   1 
ATOM   3452 C  CB  . ARG B 1 201 ? -9.23908  -6.73301  -28.97749 1.000 7.10596  ? 201 ARG B CB  1 
ATOM   3453 C  CG  . ARG B 1 201 ? -8.87686  -5.54249  -29.87559 1.000 7.43857  ? 201 ARG B CG  1 
ATOM   3454 C  CD  . ARG B 1 201 ? -9.23162  -4.26242  -29.10970 1.000 7.33352  ? 201 ARG B CD  1 
ATOM   3455 N  NE  . ARG B 1 201 ? -8.87361  -3.02089  -29.78601 1.000 8.36682  ? 201 ARG B NE  1 
ATOM   3456 C  CZ  . ARG B 1 201 ? -7.76175  -2.33692  -29.56412 1.000 7.27706  ? 201 ARG B CZ  1 
ATOM   3457 N  NH1 . ARG B 1 201 ? -6.72453  -2.88164  -28.93133 1.000 6.77733  ? 201 ARG B NH1 1 
ATOM   3458 N  NH2 . ARG B 1 201 ? -7.68544  -1.05884  -29.96936 1.000 8.43353  ? 201 ARG B NH2 1 
ATOM   3459 N  N   . ASP B 1 202 ? -7.41488  -8.56994  -31.37107 1.000 5.13997  ? 202 ASP B N   1 
ATOM   3460 C  CA  . ASP B 1 202 ? -6.11127  -8.92287  -31.93149 1.000 6.33214  ? 202 ASP B CA  1 
ATOM   3461 C  C   . ASP B 1 202 ? -5.61136  -7.76066  -32.77643 1.000 6.58426  ? 202 ASP B C   1 
ATOM   3462 O  O   . ASP B 1 202 ? -6.30908  -7.33958  -33.71620 1.000 5.12679  ? 202 ASP B O   1 
ATOM   3463 C  CB  . ASP B 1 202 ? -6.23558  -10.17201 -32.80566 1.000 5.66377  ? 202 ASP B CB  1 
ATOM   3464 C  CG  . ASP B 1 202 ? -6.63143  -11.40177 -32.00891 1.000 8.45142  ? 202 ASP B CG  1 
ATOM   3465 O  OD1 . ASP B 1 202 ? -6.44657  -11.40381 -30.76727 1.000 10.84954 ? 202 ASP B OD1 1 
ATOM   3466 O  OD2 . ASP B 1 202 ? -7.05382  -12.38578 -32.66795 1.000 9.55381  ? 202 ASP B OD2 1 
ATOM   3467 N  N   . ILE B 1 203 ? -4.41081  -7.24930  -32.45672 1.000 4.25197  ? 203 ILE B N   1 
ATOM   3468 C  CA  . ILE B 1 203 ? -3.87833  -6.03920  -33.08209 1.000 4.33679  ? 203 ILE B CA  1 
ATOM   3469 C  C   . ILE B 1 203 ? -2.39804  -6.21432  -33.39513 1.000 4.76248  ? 203 ILE B C   1 
ATOM   3470 O  O   . ILE B 1 203 ? -1.74286  -7.17666  -32.96539 1.000 4.68967  ? 203 ILE B O   1 
ATOM   3471 C  CB  . ILE B 1 203 ? -4.06856  -4.80217  -32.17591 1.000 5.79202  ? 203 ILE B CB  1 
ATOM   3472 C  CG1 . ILE B 1 203 ? -3.17028  -4.92865  -30.92848 1.000 5.63643  ? 203 ILE B CG1 1 
ATOM   3473 C  CG2 . ILE B 1 203 ? -5.51291  -4.64933  -31.72860 1.000 4.93765  ? 203 ILE B CG2 1 
ATOM   3474 C  CD1 . ILE B 1 203 ? -3.26610  -3.64499  -30.05896 1.000 8.08406  ? 203 ILE B CD1 1 
ATOM   3475 N  N   . VAL B 1 204 ? -1.87438  -5.27891  -34.16706 1.000 5.04869  ? 204 VAL B N   1 
ATOM   3476 C  CA  . VAL B 1 204 ? -0.42268  -5.13622  -34.30855 1.000 5.85444  ? 204 VAL B CA  1 
ATOM   3477 C  C   . VAL B 1 204 ? -0.08578  -3.66774  -34.14963 1.000 5.72879  ? 204 VAL B C   1 
ATOM   3478 O  O   . VAL B 1 204 ? -0.80467  -2.79680  -34.66711 1.000 7.31984  ? 204 VAL B O   1 
ATOM   3479 C  CB  . VAL B 1 204 ? 0.10348   -5.71705  -35.64137 1.000 6.70053  ? 204 VAL B CB  1 
ATOM   3480 C  CG1 . VAL B 1 204 ? -0.49268  -5.03917  -36.87744 1.000 13.18316 ? 204 VAL B CG1 1 
ATOM   3481 C  CG2 . VAL B 1 204 ? 1.66103   -5.75655  -35.65597 1.000 9.59310  ? 204 VAL B CG2 1 
ATOM   3482 N  N   . ILE B 1 205 ? 0.94816   -3.40042  -33.34910 1.000 4.19938  ? 205 ILE B N   1 
ATOM   3483 C  CA  . ILE B 1 205 ? 1.43956   -2.05319  -33.08593 1.000 5.05581  ? 205 ILE B CA  1 
ATOM   3484 C  C   . ILE B 1 205 ? 2.82205   -1.95344  -33.68693 1.000 4.69197  ? 205 ILE B C   1 
ATOM   3485 O  O   . ILE B 1 205 ? 3.68131   -2.81795  -33.45864 1.000 7.86012  ? 205 ILE B O   1 
ATOM   3486 C  CB  . ILE B 1 205 ? 1.52407   -1.76271  -31.58672 1.000 4.46003  ? 205 ILE B CB  1 
ATOM   3487 C  CG1 . ILE B 1 205 ? 0.17225   -2.03616  -30.91155 1.000 8.46115  ? 205 ILE B CG1 1 
ATOM   3488 C  CG2 . ILE B 1 205 ? 2.01704   -0.31398  -31.33850 1.000 7.48486  ? 205 ILE B CG2 1 
ATOM   3489 C  CD1 . ILE B 1 205 ? 0.31938   -2.20666  -29.43082 1.000 16.97851 ? 205 ILE B CD1 1 
ATOM   3490 N  N   . ILE B 1 206 ? 3.01348   -0.92469  -34.49425 1.000 6.74390  ? 206 ILE B N   1 
ATOM   3491 C  CA  . ILE B 1 206 ? 4.29110   -0.68837  -35.14716 1.000 7.45887  ? 206 ILE B CA  1 
ATOM   3492 C  C   . ILE B 1 206 ? 4.78152   0.69444   -34.75217 1.000 5.33750  ? 206 ILE B C   1 
ATOM   3493 O  O   . ILE B 1 206 ? 4.09742   1.69950   -34.99029 1.000 9.33023  ? 206 ILE B O   1 
ATOM   3494 C  CB  . ILE B 1 206 ? 4.19492   -0.82541  -36.66554 1.000 7.88235  ? 206 ILE B CB  1 
ATOM   3495 C  CG1 . ILE B 1 206 ? 3.63934   -2.19995  -37.05372 1.000 8.09659  ? 206 ILE B CG1 1 
ATOM   3496 C  CG2 . ILE B 1 206 ? 5.61873   -0.59379  -37.26698 1.000 8.47610  ? 206 ILE B CG2 1 
ATOM   3497 C  CD1 . ILE B 1 206 ? 2.17669   -2.09884  -37.43236 1.000 10.67987 ? 206 ILE B CD1 1 
ATOM   3498 N  N   . ALA B 1 207 ? 5.96975   0.74245   -34.16652 1.000 5.66822  ? 207 ALA B N   1 
ATOM   3499 C  CA  . ALA B 1 207 ? 6.56226   1.97551   -33.66543 1.000 6.00721  ? 207 ALA B CA  1 
ATOM   3500 C  C   . ALA B 1 207 ? 7.73176   2.29888   -34.58341 1.000 6.33108  ? 207 ALA B C   1 
ATOM   3501 O  O   . ALA B 1 207 ? 8.65303   1.47855   -34.73175 1.000 9.77600  ? 207 ALA B O   1 
ATOM   3502 C  CB  . ALA B 1 207 ? 7.00641   1.81759   -32.19879 1.000 8.30206  ? 207 ALA B CB  1 
ATOM   3503 N  N   . PHE B 1 208 ? 7.71610   3.50407   -35.14600 1.000 7.19266  ? 208 PHE B N   1 
ATOM   3504 C  CA  . PHE B 1 208 ? 8.71041   3.93465   -36.12677 1.000 9.65465  ? 208 PHE B CA  1 
ATOM   3505 C  C   . PHE B 1 208 ? 9.67999   4.94050   -35.51892 1.000 10.42112 ? 208 PHE B C   1 
ATOM   3506 O  O   . PHE B 1 208 ? 9.26619   6.01374   -35.03635 1.000 9.20252  ? 208 PHE B O   1 
ATOM   3507 C  CB  . PHE B 1 208 ? 8.07262   4.60361   -37.35251 1.000 9.31704  ? 208 PHE B CB  1 
ATOM   3508 C  CG  . PHE B 1 208 ? 7.13612   3.74472   -38.13455 1.000 10.43548 ? 208 PHE B CG  1 
ATOM   3509 C  CD1 . PHE B 1 208 ? 5.82191   3.53248   -37.68463 1.000 8.14036  ? 208 PHE B CD1 1 
ATOM   3510 C  CD2 . PHE B 1 208 ? 7.52463   3.20354   -39.32732 1.000 11.62049 ? 208 PHE B CD2 1 
ATOM   3511 C  CE1 . PHE B 1 208 ? 4.92549   2.78972   -38.43289 1.000 10.15531 ? 208 PHE B CE1 1 
ATOM   3512 C  CE2 . PHE B 1 208 ? 6.63066   2.45638   -40.08499 1.000 11.33994 ? 208 PHE B CE2 1 
ATOM   3513 C  CZ  . PHE B 1 208 ? 5.33601   2.23847   -39.64106 1.000 11.32727 ? 208 PHE B CZ  1 
ATOM   3514 N  N   . SER B 1 209 ? 10.96522  4.64414   -35.66646 1.000 9.06248  ? 209 SER B N   1 
ATOM   3515 C  CA  . SER B 1 209 ? 12.06112  5.55078   -35.32102 1.000 8.72599  ? 209 SER B CA  1 
ATOM   3516 C  C   . SER B 1 209 ? 13.09563  5.56176   -36.43865 1.000 9.31092  ? 209 SER B C   1 
ATOM   3517 O  O   . SER B 1 209 ? 13.36044  4.53646   -37.05728 1.000 11.36201 ? 209 SER B O   1 
ATOM   3518 C  CB  . SER B 1 209 ? 12.74796  5.13046   -34.03648 1.000 12.35224 ? 209 SER B CB  1 
ATOM   3519 O  OG  . SER B 1 209 ? 11.81571  5.21504   -32.97260 1.000 15.26256 ? 209 SER B OG  1 
ATOM   3520 N  N   . ARG B 1 210 ? 13.73832  6.71050   -36.62661 1.000 11.79640 ? 210 ARG B N   1 
ATOM   3521 C  CA  . ARG B 1 210 ? 14.86588  6.72711   -37.56005 1.000 10.76315 ? 210 ARG B CA  1 
ATOM   3522 C  C   . ARG B 1 210 ? 15.97226  5.82369   -37.03438 1.000 12.08499 ? 210 ARG B C   1 
ATOM   3523 O  O   . ARG B 1 210 ? 16.18583  5.70643   -35.81850 1.000 12.15956 ? 210 ARG B O   1 
ATOM   3524 C  CB  . ARG B 1 210 ? 15.37350  8.15759   -37.75269 1.000 12.52234 ? 210 ARG B CB  1 
ATOM   3525 C  CG  . ARG B 1 210 ? 14.37963  9.03793   -38.45954 1.000 13.30843 ? 210 ARG B CG  1 
ATOM   3526 C  CD  . ARG B 1 210 ? 14.61058  10.53338  -38.28058 1.000 17.09209 ? 210 ARG B CD  1 
ATOM   3527 N  NE  . ARG B 1 210 ? 13.39094  11.26073  -38.61794 1.000 17.48609 ? 210 ARG B NE  1 
ATOM   3528 C  CZ  . ARG B 1 210 ? 13.11188  11.79427  -39.79963 1.000 19.07571 ? 210 ARG B CZ  1 
ATOM   3529 N  NH1 . ARG B 1 210 ? 14.00466  11.81959  -40.77943 1.000 23.67738 ? 210 ARG B NH1 1 
ATOM   3530 N  NH2 . ARG B 1 210 ? 11.91291  12.33936  -39.99791 1.000 21.48026 ? 210 ARG B NH2 1 
ATOM   3531 N  N   . TRP B 1 211 ? 16.70705  5.18903   -37.96670 1.000 11.73038 ? 211 TRP B N   1 
ATOM   3532 C  CA  . TRP B 1 211 ? 17.78933  4.30140   -37.55056 1.000 10.72136 ? 211 TRP B CA  1 
ATOM   3533 C  C   . TRP B 1 211 ? 18.79095  5.02197   -36.65203 1.000 11.47250 ? 211 TRP B C   1 
ATOM   3534 O  O   . TRP B 1 211 ? 19.27966  4.44452   -35.67393 1.000 11.34843 ? 211 TRP B O   1 
ATOM   3535 C  CB  . TRP B 1 211 ? 18.49394  3.68569   -38.79244 1.000 10.59610 ? 211 TRP B CB  1 
ATOM   3536 C  CG  . TRP B 1 211 ? 19.49316  2.65478   -38.38914 1.000 10.38985 ? 211 TRP B CG  1 
ATOM   3537 C  CD1 . TRP B 1 211 ? 20.84212  2.85462   -38.15574 1.000 14.38373 ? 211 TRP B CD1 1 
ATOM   3538 C  CD2 . TRP B 1 211 ? 19.25570  1.26954   -38.12252 1.000 12.84767 ? 211 TRP B CD2 1 
ATOM   3539 N  NE1 . TRP B 1 211 ? 21.43237  1.69977   -37.75812 1.000 13.95430 ? 211 TRP B NE1 1 
ATOM   3540 C  CE2 . TRP B 1 211 ? 20.48774  0.70083   -37.73017 1.000 14.69268 ? 211 TRP B CE2 1 
ATOM   3541 C  CE3 . TRP B 1 211 ? 18.11859  0.45903   -38.16186 1.000 13.21863 ? 211 TRP B CE3 1 
ATOM   3542 C  CZ2 . TRP B 1 211 ? 20.61564  -0.64817  -37.38294 1.000 15.54895 ? 211 TRP B CZ2 1 
ATOM   3543 C  CZ3 . TRP B 1 211 ? 18.24770  -0.88956  -37.81257 1.000 13.79082 ? 211 TRP B CZ3 1 
ATOM   3544 C  CH2 . TRP B 1 211 ? 19.47822  -1.42641  -37.43286 1.000 14.31259 ? 211 TRP B CH2 1 
ATOM   3545 N  N   . ALA B 1 212 ? 19.03436  6.30896   -36.91896 1.000 13.13753 ? 212 ALA B N   1 
ATOM   3546 C  CA  . ALA B 1 212 ? 19.91708  7.11711   -36.09209 1.000 15.79663 ? 212 ALA B CA  1 
ATOM   3547 C  C   . ALA B 1 212 ? 19.41897  7.24195   -34.65611 1.000 18.26072 ? 212 ALA B C   1 
ATOM   3548 O  O   . ALA B 1 212 ? 20.21703  7.51637   -33.75357 1.000 16.53570 ? 212 ALA B O   1 
ATOM   3549 C  CB  . ALA B 1 212 ? 20.05520  8.50156   -36.72652 1.000 15.88435 ? 212 ALA B CB  1 
ATOM   3550 N  N   . GLU B 1 213 ? 18.12075  6.99715   -34.42072 1.000 15.74976 ? 213 GLU B N   1 
ATOM   3551 C  CA  . GLU B 1 213 ? 17.49179  7.06746   -33.10189 1.000 17.11157 ? 213 GLU B CA  1 
ATOM   3552 C  C   . GLU B 1 213 ? 16.88413  5.72348   -32.70725 1.000 16.62409 ? 213 GLU B C   1 
ATOM   3553 O  O   . GLU B 1 213 ? 15.84925  5.68147   -32.02581 1.000 14.70596 ? 213 GLU B O   1 
ATOM   3554 C  CB  . GLU B 1 213 ? 16.39471  8.12892   -33.08751 1.000 16.75866 ? 213 GLU B CB  1 
ATOM   3555 C  CG  . GLU B 1 213 ? 16.79611  9.53565   -33.45735 1.000 21.84617 ? 213 GLU B CG  1 
ATOM   3556 C  CD  . GLU B 1 213 ? 15.58713  10.45394  -33.50257 1.000 31.83059 ? 213 GLU B CD  1 
ATOM   3557 O  OE1 . GLU B 1 213 ? 15.15601  10.92595  -32.43097 1.000 48.79167 ? 213 GLU B OE1 1 
ATOM   3558 O  OE2 . GLU B 1 213 ? 15.04281  10.67550  -34.59923 1.000 32.33823 ? 213 GLU B OE2 1 
ATOM   3559 N  N   . LYS B 1 214 ? 17.49303  4.62242   -33.14236 1.000 14.14802 ? 214 LYS B N   1 
ATOM   3560 C  CA  . LYS B 1 214 ? 16.82601  3.32329   -33.10637 1.000 11.26070 ? 214 LYS B CA  1 
ATOM   3561 C  C   . LYS B 1 214 ? 16.61914  2.83478   -31.68294 1.000 13.32144 ? 214 LYS B C   1 
ATOM   3562 O  O   . LYS B 1 214 ? 17.41099  3.09974   -30.77297 1.000 13.64297 ? 214 LYS B O   1 
ATOM   3563 C  CB  . LYS B 1 214 ? 17.63242  2.26515   -33.86324 1.000 15.03607 ? 214 LYS B CB  1 
ATOM   3564 C  CG  . LYS B 1 214 ? 19.05017  2.05799   -33.33826 1.000 14.71154 ? 214 LYS B CG  1 
ATOM   3565 C  CD  . LYS B 1 214 ? 19.83006  1.23194   -34.35430 1.000 20.36868 ? 214 LYS B CD  1 
ATOM   3566 C  CE  . LYS B 1 214 ? 21.12395  0.62920   -33.77578 1.000 19.95313 ? 214 LYS B CE  1 
ATOM   3567 N  NZ  . LYS B 1 214 ? 22.19256  1.60875   -33.47051 1.000 23.49094 ? 214 LYS B NZ  1 
ATOM   3568 N  N   . TRP B 1 215 ? 15.53948  2.07971   -31.50348 1.000 11.97333 ? 215 TRP B N   1 
ATOM   3569 C  CA  . TRP B 1 215 ? 15.23021  1.42459   -30.23726 1.000 11.08186 ? 215 TRP B CA  1 
ATOM   3570 C  C   . TRP B 1 215 ? 15.74191  -0.00818  -30.23593 1.000 12.12290 ? 215 TRP B C   1 
ATOM   3571 O  O   . TRP B 1 215 ? 15.00601  -0.96436  -29.98277 1.000 13.14937 ? 215 TRP B O   1 
ATOM   3572 C  CB  . TRP B 1 215 ? 13.71921  1.46706   -29.99754 1.000 10.30028 ? 215 TRP B CB  1 
ATOM   3573 C  CG  . TRP B 1 215 ? 13.21247  2.80182   -29.57308 1.000 11.30817 ? 215 TRP B CG  1 
ATOM   3574 C  CD1 . TRP B 1 215 ? 13.42014  4.01005   -30.18409 1.000 13.37763 ? 215 TRP B CD1 1 
ATOM   3575 C  CD2 . TRP B 1 215 ? 12.40817  3.07118   -28.41656 1.000 10.58002 ? 215 TRP B CD2 1 
ATOM   3576 N  NE1 . TRP B 1 215 ? 12.78410  5.02087   -29.47170 1.000 15.18531 ? 215 TRP B NE1 1 
ATOM   3577 C  CE2 . TRP B 1 215 ? 12.17576  4.46198   -28.37830 1.000 15.17096 ? 215 TRP B CE2 1 
ATOM   3578 C  CE3 . TRP B 1 215 ? 11.89161  2.27366   -27.39704 1.000 14.89439 ? 215 TRP B CE3 1 
ATOM   3579 C  CZ2 . TRP B 1 215 ? 11.41221  5.07122   -27.35525 1.000 16.62261 ? 215 TRP B CZ2 1 
ATOM   3580 C  CZ3 . TRP B 1 215 ? 11.12706  2.87158   -26.40843 1.000 13.05366 ? 215 TRP B CZ3 1 
ATOM   3581 C  CH2 . TRP B 1 215 ? 10.90666  4.25251   -26.39133 1.000 13.61891 ? 215 TRP B CH2 1 
ATOM   3582 N  N   . TYR B 1 216 ? 17.03191  -0.19239  -30.52452 1.000 10.40015 ? 216 TYR B N   1 
ATOM   3583 C  CA  . TYR B 1 216 ? 17.56043  -1.51739  -30.80024 1.000 10.45782 ? 216 TYR B CA  1 
ATOM   3584 C  C   . TYR B 1 216 ? 19.04534  -1.50338  -30.47322 1.000 10.35437 ? 216 TYR B C   1 
ATOM   3585 O  O   . TYR B 1 216 ? 19.72834  -0.57161  -30.90799 1.000 14.98180 ? 216 TYR B O   1 
ATOM   3586 C  CB  . TYR B 1 216 ? 17.37964  -1.86684  -32.28337 1.000 11.62820 ? 216 TYR B CB  1 
ATOM   3587 C  CG  . TYR B 1 216 ? 17.82383  -3.26636  -32.59842 1.000 10.29252 ? 216 TYR B CG  1 
ATOM   3588 C  CD1 . TYR B 1 216 ? 16.99760  -4.36015  -32.33946 1.000 11.59548 ? 216 TYR B CD1 1 
ATOM   3589 C  CD2 . TYR B 1 216 ? 19.08078  -3.50476  -33.13462 1.000 14.47934 ? 216 TYR B CD2 1 
ATOM   3590 C  CE1 . TYR B 1 216 ? 17.40793  -5.66439  -32.60763 1.000 11.48788 ? 216 TYR B CE1 1 
ATOM   3591 C  CE2 . TYR B 1 216 ? 19.49949  -4.80421  -33.40548 1.000 13.23804 ? 216 TYR B CE2 1 
ATOM   3592 C  CZ  . TYR B 1 216 ? 18.67895  -5.86638  -33.16038 1.000 13.69970 ? 216 TYR B CZ  1 
ATOM   3593 O  OH  . TYR B 1 216 ? 19.10807  -7.15177  -33.41079 1.000 15.35460 ? 216 TYR B OH  1 
ATOM   3594 N  N   . GLY B 1 217 ? 19.52659  -2.50107  -29.73387 1.000 11.69881 ? 217 GLY B N   1 
ATOM   3595 C  CA  . GLY B 1 217 ? 20.96322  -2.64423  -29.50962 1.000 15.54845 ? 217 GLY B CA  1 
ATOM   3596 C  C   . GLY B 1 217 ? 21.39815  -2.21380  -28.11592 1.000 19.47866 ? 217 GLY B C   1 
ATOM   3597 O  O   . GLY B 1 217 ? 20.60521  -1.76003  -27.29201 1.000 15.22603 ? 217 GLY B O   1 
ATOM   3598 N  N   . ASP B 1 218 ? 22.71141  -2.36041  -27.85752 1.000 17.86061 ? 218 ASP B N   1 
ATOM   3599 C  CA  . ASP B 1 218 ? 23.23662  -2.22000  -26.49486 1.000 18.99023 ? 218 ASP B CA  1 
ATOM   3600 C  C   . ASP B 1 218 ? 23.08895  -0.80562  -25.95637 1.000 17.18017 ? 218 ASP B C   1 
ATOM   3601 O  O   . ASP B 1 218 ? 22.86315  -0.61995  -24.75399 1.000 15.86151 ? 218 ASP B O   1 
ATOM   3602 C  CB  . ASP B 1 218 ? 24.72591  -2.58883  -26.43552 1.000 24.80951 ? 218 ASP B CB  1 
ATOM   3603 C  CG  . ASP B 1 218 ? 25.01017  -4.06162  -26.66948 1.000 26.93726 ? 218 ASP B CG  1 
ATOM   3604 O  OD1 . ASP B 1 218 ? 24.19031  -4.92006  -26.28269 1.000 33.31202 ? 218 ASP B OD1 1 
ATOM   3605 O  OD2 . ASP B 1 218 ? 26.11437  -4.33485  -27.20981 1.000 29.83097 ? 218 ASP B OD2 1 
ATOM   3606 N  N   . GLU B 1 219 ? 23.27014  0.20475   -26.80667 1.000 18.48523 ? 219 GLU B N   1 
ATOM   3607 C  CA  . GLU B 1 219 ? 23.19033  1.57754   -26.32709 1.000 19.50586 ? 219 GLU B CA  1 
ATOM   3608 C  C   . GLU B 1 219 ? 21.75970  1.91214   -25.91966 1.000 18.04809 ? 219 GLU B C   1 
ATOM   3609 O  O   . GLU B 1 219 ? 21.52648  2.44111   -24.82551 1.000 17.04640 ? 219 GLU B O   1 
ATOM   3610 C  CB  . GLU B 1 219 ? 23.69402  2.55286   -27.39300 1.000 27.47300 ? 219 GLU B CB  1 
ATOM   3611 C  CG  . GLU B 1 219 ? 23.59103  4.03423   -26.96747 1.000 29.07302 ? 219 GLU B CG  1 
ATOM   3612 C  CD  . GLU B 1 219 ? 24.15736  5.01059   -27.99888 1.000 40.27817 ? 219 GLU B CD  1 
ATOM   3613 O  OE1 . GLU B 1 219 ? 24.37686  4.60862   -29.16470 1.000 40.04079 ? 219 GLU B OE1 1 
ATOM   3614 O  OE2 . GLU B 1 219 ? 24.37227  6.18935   -27.63754 1.000 38.17835 ? 219 GLU B OE2 1 
ATOM   3615 N  N   . HIS B 1 220 ? 20.79355  1.60264   -26.79127 1.000 15.13804 ? 220 HIS B N   1 
ATOM   3616 C  CA  . HIS B 1 220 ? 19.39012  1.76488   -26.42857 1.000 12.92812 ? 220 HIS B CA  1 
ATOM   3617 C  C   . HIS B 1 220 ? 19.05981  1.01206   -25.13878 1.000 15.33580 ? 220 HIS B C   1 
ATOM   3618 O  O   . HIS B 1 220 ? 18.40726  1.55963   -24.24107 1.000 14.78300 ? 220 HIS B O   1 
ATOM   3619 C  CB  . HIS B 1 220 ? 18.46830  1.30418   -27.57581 1.000 10.92251 ? 220 HIS B CB  1 
ATOM   3620 C  CG  . HIS B 1 220 ? 17.05653  1.10059   -27.12695 1.000 10.00389 ? 220 HIS B CG  1 
ATOM   3621 N  ND1 . HIS B 1 220 ? 16.20721  2.15166   -26.86598 1.000 13.03427 ? 220 HIS B ND1 1 
ATOM   3622 C  CD2 . HIS B 1 220 ? 16.39866  -0.02340  -26.76731 1.000 14.52888 ? 220 HIS B CD2 1 
ATOM   3623 C  CE1 . HIS B 1 220 ? 15.06100  1.67724   -26.40553 1.000 10.94846 ? 220 HIS B CE1 1 
ATOM   3624 N  NE2 . HIS B 1 220 ? 15.16032  0.36554   -26.31448 1.000 10.87987 ? 220 HIS B NE2 1 
ATOM   3625 N  N   . ASP B 1 221 ? 19.47532  -0.25872  -25.03418 1.000 11.68708 ? 221 ASP B N   1 
ATOM   3626 C  CA  . ASP B 1 221 ? 19.14063  -1.04093  -23.84654 1.000 11.31701 ? 221 ASP B CA  1 
ATOM   3627 C  C   . ASP B 1 221 ? 19.67911  -0.37962  -22.59013 1.000 14.36361 ? 221 ASP B C   1 
ATOM   3628 O  O   . ASP B 1 221 ? 18.98428  -0.30717  -21.56753 1.000 13.55731 ? 221 ASP B O   1 
ATOM   3629 C  CB  . ASP B 1 221 ? 19.69261  -2.46381  -23.94777 1.000 14.91821 ? 221 ASP B CB  1 
ATOM   3630 C  CG  . ASP B 1 221 ? 18.94366  -3.32897  -24.93664 1.000 17.48774 ? 221 ASP B CG  1 
ATOM   3631 O  OD1 . ASP B 1 221 ? 17.85115  -2.92330  -25.42122 1.000 16.18921 ? 221 ASP B OD1 1 
ATOM   3632 O  OD2 . ASP B 1 221 ? 19.46178  -4.43082  -25.20364 1.000 16.19289 ? 221 ASP B OD2 1 
ATOM   3633 N  N   . ALA B 1 222 ? 20.92908  0.08364   -22.63954 1.000 17.56937 ? 222 ALA B N   1 
ATOM   3634 C  CA  . ALA B 1 222 ? 21.52863  0.67190   -21.44759 1.000 20.10137 ? 222 ALA B CA  1 
ATOM   3635 C  C   . ALA B 1 222 ? 20.79220  1.92580   -21.03766 1.000 18.68600 ? 222 ALA B C   1 
ATOM   3636 O  O   . ALA B 1 222 ? 20.60950  2.18076   -19.83808 1.000 20.34846 ? 222 ALA B O   1 
ATOM   3637 C  CB  . ALA B 1 222 ? 22.99836  0.99886   -21.69868 1.000 16.85625 ? 222 ALA B CB  1 
ATOM   3638 N  N   . ALA B 1 223 ? 20.35687  2.71558   -22.02088 1.000 13.72753 ? 223 ALA B N   1 
ATOM   3639 C  CA  . ALA B 1 223 ? 19.62248  3.94549   -21.73204 1.000 16.00236 ? 223 ALA B CA  1 
ATOM   3640 C  C   . ALA B 1 223 ? 18.24104  3.62819   -21.16325 1.000 18.72938 ? 223 ALA B C   1 
ATOM   3641 O  O   . ALA B 1 223 ? 17.78824  4.26554   -20.20636 1.000 19.03553 ? 223 ALA B O   1 
ATOM   3642 C  CB  . ALA B 1 223 ? 19.52564  4.80389   -22.99337 1.000 17.98725 ? 223 ALA B CB  1 
ATOM   3643 N  N   . ALA B 1 224 ? 17.55859  2.63576   -21.72775 1.000 15.54442 ? 224 ALA B N   1 
ATOM   3644 C  CA  . ALA B 1 224 ? 16.20733  2.35452   -21.25487 1.000 14.10006 ? 224 ALA B CA  1 
ATOM   3645 C  C   . ALA B 1 224 ? 16.21050  1.71600   -19.87490 1.000 14.86760 ? 224 ALA B C   1 
ATOM   3646 O  O   . ALA B 1 224 ? 15.26803  1.93300   -19.09850 1.000 15.39705 ? 224 ALA B O   1 
ATOM   3647 C  CB  . ALA B 1 224 ? 15.48094  1.42395   -22.22859 1.000 12.95729 ? 224 ALA B CB  1 
ATOM   3648 N  N   . LEU B 1 225 ? 17.23337  0.90971   -19.56723 1.000 15.61094 ? 225 LEU B N   1 
ATOM   3649 C  CA  . LEU B 1 225 ? 17.38497  0.22912   -18.28382 1.000 14.37634 ? 225 LEU B CA  1 
ATOM   3650 C  C   . LEU B 1 225 ? 18.07752  1.10269   -17.24154 1.000 19.44315 ? 225 LEU B C   1 
ATOM   3651 O  O   . LEU B 1 225 ? 18.24851  0.65539   -16.10075 1.000 21.81919 ? 225 LEU B O   1 
ATOM   3652 C  CB  . LEU B 1 225 ? 18.17643  -1.07236  -18.46688 1.000 17.13792 ? 225 LEU B CB  1 
ATOM   3653 C  CG  . LEU B 1 225 ? 17.51759  -2.11272  -19.37639 1.000 18.89872 ? 225 LEU B CG  1 
ATOM   3654 C  CD1 . LEU B 1 225 ? 18.44002  -3.29605  -19.58187 1.000 21.82503 ? 225 LEU B CD1 1 
ATOM   3655 C  CD2 . LEU B 1 225 ? 16.20434  -2.60557  -18.82914 1.000 21.58802 ? 225 LEU B CD2 1 
ATOM   3656 N  N   . GLU B 1 226 ? 18.46866  2.32478   -17.62940 1.000 17.62517 ? 226 GLU B N   1 
ATOM   3657 C  CA  . GLU B 1 226 ? 19.16385  3.30178   -16.77797 1.000 21.86592 ? 226 GLU B CA  1 
ATOM   3658 C  C   . GLU B 1 226 ? 20.44638  2.72395   -16.19545 1.000 38.13366 ? 226 GLU B C   1 
ATOM   3659 O  O   . GLU B 1 226 ? 20.76634  2.92094   -15.02099 1.000 44.21726 ? 226 GLU B O   1 
ATOM   3660 C  CB  . GLU B 1 226 ? 18.22799  3.83411   -15.69859 1.000 27.94697 ? 226 GLU B CB  1 
ATOM   3661 C  CG  . GLU B 1 226 ? 17.18793  4.74746   -16.31465 1.000 33.73179 ? 226 GLU B CG  1 
ATOM   3662 C  CD  . GLU B 1 226 ? 16.19368  5.31191   -15.32216 1.000 50.30912 ? 226 GLU B CD  1 
ATOM   3663 O  OE1 . GLU B 1 226 ? 15.46839  4.51914   -14.68811 1.000 51.23631 ? 226 GLU B OE1 1 
ATOM   3664 O  OE2 . GLU B 1 226 ? 16.12871  6.55205   -15.18503 1.000 57.51240 ? 226 GLU B OE2 1 
ATOM   3665 N  N   . GLU B 1 227 ? 21.20568  2.03758   -17.04664 1.000 29.63726 ? 227 GLU B N   1 
ATOM   3666 C  CA  . GLU B 1 227 ? 22.45108  1.40005   -16.64808 1.000 42.05227 ? 227 GLU B CA  1 
ATOM   3667 C  C   . GLU B 1 227 ? 23.63881  2.35457   -16.77951 1.000 56.64773 ? 227 GLU B C   1 
ATOM   3668 O  O   . GLU B 1 227 ? 23.67795  3.19894   -17.67916 1.000 54.75662 ? 227 GLU B O   1 
ATOM   3669 C  CB  . GLU B 1 227 ? 22.67839  0.14227   -17.49238 1.000 35.74577 ? 227 GLU B CB  1 
ATOM   3670 C  CG  . GLU B 1 227 ? 21.71159  -0.97655  -17.15505 1.000 43.06753 ? 227 GLU B CG  1 
ATOM   3671 C  CD  . GLU B 1 227 ? 21.83199  -2.17081  -18.08125 1.000 41.56059 ? 227 GLU B CD  1 
ATOM   3672 O  OE1 . GLU B 1 227 ? 22.39911  -2.01533  -19.18831 1.000 47.57598 ? 227 GLU B OE1 1 
ATOM   3673 O  OE2 . GLU B 1 227 ? 21.35769  -3.26761  -17.69469 1.000 44.01279 ? 227 GLU B OE2 1 
HETATM 3674 N  N1  . 6HN C 2 .   ? -7.45442  -0.00190  -0.05673  1.000 20.80737 ? 301 6HN A N1  1 
HETATM 3675 N  N   . 6HN C 2 .   ? -3.57955  0.01665   -3.98653  1.000 20.20769 ? 301 6HN A N   1 
HETATM 3676 C  CA  . 6HN C 2 .   ? -3.54236  -1.29364  -3.33428  1.000 16.06070 ? 301 6HN A CA  1 
HETATM 3677 C  C   . 6HN C 2 .   ? -4.08045  -2.32751  -4.32113  1.000 24.19726 ? 301 6HN A C   1 
HETATM 3678 O  OXT . 6HN C 2 .   ? -4.84137  -1.95819  -5.24895  1.000 19.51578 ? 301 6HN A OXT 1 
HETATM 3679 O  O   . 6HN C 2 .   ? -3.78320  -3.53825  -4.16515  1.000 21.18923 ? 301 6HN A O   1 
HETATM 3680 C  CB  . 6HN C 2 .   ? -4.45959  -1.33327  -2.10094  1.000 16.36109 ? 301 6HN A CB  1 
HETATM 3681 C  CG  . 6HN C 2 .   ? -3.89748  -0.48814  -0.95927  1.000 19.09738 ? 301 6HN A CG  1 
HETATM 3682 C  CD  . 6HN C 2 .   ? -4.92088  -0.36121  0.17550   1.000 16.86588 ? 301 6HN A CD  1 
HETATM 3683 C  CE  . 6HN C 2 .   ? -6.09272  0.50408   -0.28930  1.000 16.29561 ? 301 6HN A CE  1 
HETATM 3684 O  O2  . 6HN C 2 .   ? -7.71848  -0.82494  0.75697   1.000 14.48145 ? 301 6HN A O2  1 
HETATM 3685 O  O1  . 6HN C 2 .   ? -8.34662  0.44346   -0.72323  1.000 19.85987 ? 301 6HN A O1  1 
HETATM 3686 O  O1  . VVO D 3 .   ? -1.56507  1.71315   -2.38703  1.000 13.39958 ? 302 VVO A O1  1 
HETATM 3687 V  V1  . VVO D 3 .   ? -0.93299  2.97899   -1.58428  1.000 10.93211 ? 302 VVO A V1  1 
HETATM 3688 C  C1  . SIN E 4 .   ? 1.29126   1.01814   -1.24638  1.000 20.61124 ? 303 SIN A C1  1 
HETATM 3689 O  O1  . SIN E 4 .   ? 0.97695   2.13372   -1.65821  1.000 11.64098 ? 303 SIN A O1  1 
HETATM 3690 O  O2  . SIN E 4 .   ? 0.40590   0.24489   -0.81904  1.000 23.91710 ? 303 SIN A O2  1 
HETATM 3691 C  C2  . SIN E 4 .   ? 2.72190   0.61636   -1.30252  1.000 16.41131 ? 303 SIN A C2  1 
HETATM 3692 C  C3  . SIN E 4 .   ? 2.97009   -0.19095  -0.03845  1.000 14.70839 ? 303 SIN A C3  1 
HETATM 3693 C  C4  . SIN E 4 .   ? 4.37158   -0.71178  -0.03403  1.000 11.53612 ? 303 SIN A C4  1 
HETATM 3694 O  O3  . SIN E 4 .   ? 4.66341   -1.68580  -0.77353  1.000 12.94847 ? 303 SIN A O3  1 
HETATM 3695 O  O4  . SIN E 4 .   ? 5.21980   -0.20521  0.73877   1.000 11.75760 ? 303 SIN A O4  1 
HETATM 3696 C  C1  . GOL F 5 .   ? -0.48216  16.31376  6.21000   1.000 30.60087 ? 304 GOL A C1  1 
HETATM 3697 O  O1  . GOL F 5 .   ? -1.05154  16.06238  7.48072   1.000 29.28420 ? 304 GOL A O1  1 
HETATM 3698 C  C2  . GOL F 5 .   ? 0.11735   17.70275  6.12222   1.000 48.55646 ? 304 GOL A C2  1 
HETATM 3699 O  O2  . GOL F 5 .   ? 0.80635   17.98880  7.32147   1.000 49.46070 ? 304 GOL A O2  1 
HETATM 3700 C  C3  . GOL F 5 .   ? 1.06199   17.74996  4.92670   1.000 44.38642 ? 304 GOL A C3  1 
HETATM 3701 O  O3  . GOL F 5 .   ? 1.41745   19.09216  4.65245   1.000 50.55415 ? 304 GOL A O3  1 
HETATM 3702 C  C1  . GOL G 5 .   ? -25.02340 7.07966   5.41504   1.000 47.54758 ? 305 GOL A C1  1 
HETATM 3703 O  O1  . GOL G 5 .   ? -25.36455 5.71303   5.30706   1.000 43.91093 ? 305 GOL A O1  1 
HETATM 3704 C  C2  . GOL G 5 .   ? -23.51593 7.22670   5.53527   1.000 42.67663 ? 305 GOL A C2  1 
HETATM 3705 O  O2  . GOL G 5 .   ? -22.87694 6.09824   4.97135   1.000 51.40558 ? 305 GOL A O2  1 
HETATM 3706 C  C3  . GOL G 5 .   ? -23.05061 8.56596   4.95896   1.000 42.10083 ? 305 GOL A C3  1 
HETATM 3707 O  O3  . GOL G 5 .   ? -22.25360 8.37327   3.80245   1.000 47.45197 ? 305 GOL A O3  1 
HETATM 3708 BR BR  . BR  H 6 .   ? -0.03059  -3.87209  -12.23288 1.000 22.71798 ? 306 BR  A BR  1 
HETATM 3709 BR BR  . BR  I 6 .   ? 16.58060  4.41508   4.80577   1.000 35.76448 ? 307 BR  A BR  1 
HETATM 3710 BR BR  . BR  J 6 .   ? -21.03879 -4.66478  15.30389  1.000 43.77726 ? 308 BR  A BR  1 
HETATM 3711 N  N1  . 6HN K 2 .   ? 7.52199   0.50207   -28.62285 1.000 20.46169 ? 301 6HN B N1  1 
HETATM 3712 N  N   . 6HN K 2 .   ? 3.61360   0.34947   -24.69146 1.000 23.21806 ? 301 6HN B N   1 
HETATM 3713 C  CA  . 6HN K 2 .   ? 3.59687   -0.94364  -25.37153 1.000 18.54866 ? 301 6HN B CA  1 
HETATM 3714 C  C   . 6HN K 2 .   ? 4.16234   -1.98665  -24.40606 1.000 21.17880 ? 301 6HN B C   1 
HETATM 3715 O  OXT . 6HN K 2 .   ? 3.86872   -3.19624  -24.58239 1.000 20.42952 ? 301 6HN B OXT 1 
HETATM 3716 O  O   . 6HN K 2 .   ? 4.93008   -1.62604  -23.47025 1.000 19.68682 ? 301 6HN B O   1 
HETATM 3717 C  CB  . 6HN K 2 .   ? 4.45996   -0.96004  -26.63509 1.000 19.33690 ? 301 6HN B CB  1 
HETATM 3718 C  CG  . 6HN K 2 .   ? 3.96575   -0.00140  -27.71557 1.000 17.26966 ? 301 6HN B CG  1 
HETATM 3719 C  CD  . 6HN K 2 .   ? 5.01304   0.12915   -28.82151 1.000 17.57088 ? 301 6HN B CD  1 
HETATM 3720 C  CE  . 6HN K 2 .   ? 6.17805   1.00903   -28.36396 1.000 17.18550 ? 301 6HN B CE  1 
HETATM 3721 O  O2  . 6HN K 2 .   ? 7.76432   -0.34321  -29.43033 1.000 13.00289 ? 301 6HN B O2  1 
HETATM 3722 O  O1  . 6HN K 2 .   ? 8.41531   0.95185   -27.95512 1.000 24.06976 ? 301 6HN B O1  1 
HETATM 3723 O  O1  . VVO L 3 .   ? 1.57680   2.03996   -26.22168 1.000 13.02592 ? 302 VVO B O1  1 
HETATM 3724 V  V1  . VVO L 3 .   ? 0.93232   3.31670   -27.01655 1.000 10.92734 ? 302 VVO B V1  1 
HETATM 3725 C  C1  . SIN M 4 .   ? -4.32571  -0.37280  -28.67638 1.000 9.86137  ? 303 SIN B C1  1 
HETATM 3726 O  O1  . SIN M 4 .   ? -5.14077  0.15259   -29.46699 1.000 11.73712 ? 303 SIN B O1  1 
HETATM 3727 O  O2  . SIN M 4 .   ? -4.64241  -1.32942  -27.92274 1.000 12.15329 ? 303 SIN B O2  1 
HETATM 3728 C  C2  . SIN M 4 .   ? -2.92015  0.15473   -28.65101 1.000 13.74663 ? 303 SIN B C2  1 
HETATM 3729 C  C3  . SIN M 4 .   ? -2.68743  0.87028   -27.32758 1.000 16.74299 ? 303 SIN B C3  1 
HETATM 3730 C  C4  . SIN M 4 .   ? -1.29506  1.39065   -27.42011 1.000 20.66596 ? 303 SIN B C4  1 
HETATM 3731 O  O3  . SIN M 4 .   ? -1.01963  2.46097   -26.85363 1.000 14.46275 ? 303 SIN B O3  1 
HETATM 3732 O  O4  . SIN M 4 .   ? -0.42041  0.76944   -28.06378 1.000 23.32434 ? 303 SIN B O4  1 
HETATM 3733 C  C1  . GOL N 5 .   ? 4.34063   15.56692  -41.26396 1.000 62.61387 ? 304 GOL B C1  1 
HETATM 3734 O  O1  . GOL N 5 .   ? 3.12093   16.07068  -41.76421 1.000 52.78958 ? 304 GOL B O1  1 
HETATM 3735 C  C2  . GOL N 5 .   ? 4.49744   14.08973  -41.58192 1.000 51.53992 ? 304 GOL B C2  1 
HETATM 3736 O  O2  . GOL N 5 .   ? 5.72631   13.60801  -41.08074 1.000 57.52224 ? 304 GOL B O2  1 
HETATM 3737 C  C3  . GOL N 5 .   ? 3.34993   13.29739  -40.98276 1.000 46.21030 ? 304 GOL B C3  1 
HETATM 3738 O  O3  . GOL N 5 .   ? 3.30160   12.06247  -41.67595 1.000 39.10726 ? 304 GOL B O3  1 
HETATM 3739 C  C1  . GOL O 5 .   ? 16.60255  7.63942   -28.99022 1.000 40.86210 ? 305 GOL B C1  1 
HETATM 3740 O  O1  . GOL O 5 .   ? 18.01359  7.60141   -29.02748 1.000 49.73404 ? 305 GOL B O1  1 
HETATM 3741 C  C2  . GOL O 5 .   ? 16.11284  6.85161   -27.79020 1.000 40.51806 ? 305 GOL B C2  1 
HETATM 3742 O  O2  . GOL O 5 .   ? 14.90571  7.37547   -27.25331 1.000 42.53759 ? 305 GOL B O2  1 
HETATM 3743 C  C3  . GOL O 5 .   ? 16.04036  5.36136   -28.09688 1.000 19.18538 ? 305 GOL B C3  1 
HETATM 3744 O  O3  . GOL O 5 .   ? 16.82023  4.78830   -27.06302 1.000 16.63288 ? 305 GOL B O3  1 
HETATM 3745 C  C1  . GOL P 5 .   ? 26.21233  0.75872   -24.14266 1.000 42.67131 ? 306 GOL B C1  1 
HETATM 3746 O  O1  . GOL P 5 .   ? 26.76402  0.77206   -25.44278 1.000 38.15905 ? 306 GOL B O1  1 
HETATM 3747 C  C2  . GOL P 5 .   ? 26.52110  2.09354   -23.46739 1.000 34.56762 ? 306 GOL B C2  1 
HETATM 3748 O  O2  . GOL P 5 .   ? 25.68042  3.10474   -23.98079 1.000 40.09970 ? 306 GOL B O2  1 
HETATM 3749 C  C3  . GOL P 5 .   ? 26.41251  2.02169   -21.94370 1.000 38.54359 ? 306 GOL B C3  1 
HETATM 3750 O  O3  . GOL P 5 .   ? 27.22817  0.97923   -21.44859 1.000 47.23458 ? 306 GOL B O3  1 
HETATM 3751 BR BR  . BR  Q 6 .   ? 0.10906   -3.83596  -16.48181 1.000 23.73408 ? 307 BR  B BR  1 
HETATM 3752 O  O   . HOH R 7 .   ? -21.34359 -5.92416  -5.24089  1.000 26.77933 ? 401 HOH A O   1 
HETATM 3753 O  O   . HOH R 7 .   ? 9.80447   15.06804  7.35332   1.000 32.27761 ? 402 HOH A O   1 
HETATM 3754 O  O   . HOH R 7 .   ? -0.49411  14.78126  13.97230  1.000 42.99648 ? 403 HOH A O   1 
HETATM 3755 O  O   . HOH R 7 .   ? 11.17957  -14.90831 -4.87830  1.000 32.53342 ? 404 HOH A O   1 
HETATM 3756 O  O   . HOH R 7 .   ? -14.54221 2.89406   -13.32562 1.000 30.54709 ? 405 HOH A O   1 
HETATM 3757 O  O   . HOH R 7 .   ? -22.654   -8.917    14.479    1.000 30.84501 ? 406 HOH A O   1 
HETATM 3758 O  O   . HOH R 7 .   ? -15.98025 -6.01060  18.20940  1.000 30.08771 ? 407 HOH A O   1 
HETATM 3759 O  O   . HOH R 7 .   ? -22.24332 -3.83442  -8.39116  1.000 43.44366 ? 408 HOH A O   1 
HETATM 3760 O  O   . HOH R 7 .   ? 12.90601  -10.14053 7.52242   1.000 19.93394 ? 409 HOH A O   1 
HETATM 3761 O  O   . HOH R 7 .   ? -17.09692 11.47312  15.07808  1.000 26.12263 ? 410 HOH A O   1 
HETATM 3762 O  O   . HOH R 7 .   ? -3.21701  -16.53538 13.81311  1.000 44.26134 ? 411 HOH A O   1 
HETATM 3763 O  O   . HOH R 7 .   ? -18.39901 6.96642   -14.18494 1.000 44.02207 ? 412 HOH A O   1 
HETATM 3764 O  O   . HOH R 7 .   ? -0.02874  0.57940   -4.47508  1.000 30.72275 ? 413 HOH A O   1 
HETATM 3765 O  O   . HOH R 7 .   ? 11.68047  2.71177   13.81183  1.000 28.91319 ? 414 HOH A O   1 
HETATM 3766 O  O   . HOH R 7 .   ? 5.80173   19.06244  5.69258   1.000 48.35336 ? 415 HOH A O   1 
HETATM 3767 O  O   . HOH R 7 .   ? -7.39539  -11.37453 18.19378  1.000 39.15725 ? 416 HOH A O   1 
HETATM 3768 O  O   . HOH R 7 .   ? -12.91307 8.30578   6.70313   1.000 13.03361 ? 417 HOH A O   1 
HETATM 3769 O  O   . HOH R 7 .   ? 2.51147   -8.45380  18.09513  1.000 29.50708 ? 418 HOH A O   1 
HETATM 3770 O  O   . HOH R 7 .   ? -1.16460  2.16534   0.46065   1.000 17.18822 ? 419 HOH A O   1 
HETATM 3771 O  O   . HOH R 7 .   ? -21.70529 2.52019   2.86982   1.000 29.56437 ? 420 HOH A O   1 
HETATM 3772 O  O   . HOH R 7 .   ? 15.848    -11.458   6.072     1.000 35.05579 ? 421 HOH A O   1 
HETATM 3773 O  O   . HOH R 7 .   ? 3.08493   10.57161  15.54972  1.000 29.57826 ? 422 HOH A O   1 
HETATM 3774 O  O   . HOH R 7 .   ? 15.41655  -2.65744  0.64151   1.000 17.71928 ? 423 HOH A O   1 
HETATM 3775 O  O   . HOH R 7 .   ? -3.89346  -17.51046 -11.01824 1.000 33.17481 ? 424 HOH A O   1 
HETATM 3776 O  O   . HOH R 7 .   ? -8.31479  -19.37397 1.85732   1.000 30.96682 ? 425 HOH A O   1 
HETATM 3777 O  O   . HOH R 7 .   ? -14.21441 4.01425   -16.13907 1.000 48.70295 ? 426 HOH A O   1 
HETATM 3778 O  O   . HOH R 7 .   ? -1.79488  -15.01945 13.98849  1.000 28.92336 ? 427 HOH A O   1 
HETATM 3779 O  O   . HOH R 7 .   ? 17.52456  -0.76172  3.11998   1.000 33.17579 ? 428 HOH A O   1 
HETATM 3780 O  O   . HOH R 7 .   ? -18.54625 6.25447   11.25419  1.000 15.91251 ? 429 HOH A O   1 
HETATM 3781 O  O   . HOH R 7 .   ? -16.75031 4.24355   -1.44939  1.000 15.30425 ? 430 HOH A O   1 
HETATM 3782 O  O   . HOH R 7 .   ? -17.14762 -11.52867 -8.29782  1.000 25.33848 ? 431 HOH A O   1 
HETATM 3783 O  O   . HOH R 7 .   ? 7.55765   -14.01083 5.96938   1.000 19.12500 ? 432 HOH A O   1 
HETATM 3784 O  O   . HOH R 7 .   ? -10.86828 9.78479   1.28941   1.000 27.14417 ? 433 HOH A O   1 
HETATM 3785 O  O   . HOH R 7 .   ? -13.91285 -12.48270 -2.74309  1.000 23.08498 ? 434 HOH A O   1 
HETATM 3786 O  O   . HOH R 7 .   ? 7.83758   6.93669   16.03449  1.000 34.56170 ? 435 HOH A O   1 
HETATM 3787 O  O   . HOH R 7 .   ? 5.68123   1.93837   2.14450   1.000 13.16485 ? 436 HOH A O   1 
HETATM 3788 O  O   . HOH R 7 .   ? -21.47550 0.26880   1.08878   1.000 17.66431 ? 437 HOH A O   1 
HETATM 3789 O  O   . HOH R 7 .   ? -13.64058 -10.03124 -11.43290 1.000 22.82270 ? 438 HOH A O   1 
HETATM 3790 O  O   . HOH R 7 .   ? -4.76597  -16.47548 -7.34263  1.000 20.72955 ? 439 HOH A O   1 
HETATM 3791 O  O   . HOH R 7 .   ? -5.88088  -5.07279  -12.78622 1.000 18.02889 ? 440 HOH A O   1 
HETATM 3792 O  O   . HOH R 7 .   ? 7.31763   -16.77124 4.47038   1.000 44.92602 ? 441 HOH A O   1 
HETATM 3793 O  O   . HOH R 7 .   ? -20.95607 7.75543   17.19596  1.000 14.84690 ? 442 HOH A O   1 
HETATM 3794 O  O   . HOH R 7 .   ? 14.71071  2.17730   8.56366   1.000 21.60230 ? 443 HOH A O   1 
HETATM 3795 O  O   . HOH R 7 .   ? -0.70409  -4.71654  19.99377  1.000 28.97931 ? 444 HOH A O   1 
HETATM 3796 O  O   . HOH R 7 .   ? -1.22901  8.91819   0.63209   1.000 16.79442 ? 445 HOH A O   1 
HETATM 3797 O  O   . HOH R 7 .   ? -17.64673 12.21197  10.81118  1.000 33.93863 ? 446 HOH A O   1 
HETATM 3798 O  O   . HOH R 7 .   ? 4.44599   -6.85237  -6.92444  1.000 10.85126 ? 447 HOH A O   1 
HETATM 3799 O  O   . HOH R 7 .   ? 9.83271   1.15686   2.35576   1.000 10.68151 ? 448 HOH A O   1 
HETATM 3800 O  O   . HOH R 7 .   ? -6.53519  12.20386  6.51688   1.000 17.08545 ? 449 HOH A O   1 
HETATM 3801 O  O   . HOH R 7 .   ? -11.87806 7.27227   4.22508   1.000 13.35959 ? 450 HOH A O   1 
HETATM 3802 O  O   . HOH R 7 .   ? -1.52157  8.16306   -9.42189  1.000 38.60285 ? 451 HOH A O   1 
HETATM 3803 O  O   . HOH R 7 .   ? -17.836   1.295     20.404    1.000 41.61347 ? 452 HOH A O   1 
HETATM 3804 O  O   . HOH R 7 .   ? 18.94286  -7.30680  1.64639   1.000 26.32206 ? 453 HOH A O   1 
HETATM 3805 O  O   . HOH R 7 .   ? 7.28164   0.18630   -7.27947  1.000 11.29754 ? 454 HOH A O   1 
HETATM 3806 O  O   . HOH R 7 .   ? -20.01965 -11.97406 1.60540   1.000 29.94687 ? 455 HOH A O   1 
HETATM 3807 O  O   . HOH R 7 .   ? 1.45873   11.27934  18.83014  1.000 47.01981 ? 456 HOH A O   1 
HETATM 3808 O  O   . HOH R 7 .   ? -12.11873 -12.03690 4.87107   1.000 13.30030 ? 457 HOH A O   1 
HETATM 3809 O  O   . HOH R 7 .   ? 17.95061  -16.07426 -2.95574  1.000 24.44065 ? 458 HOH A O   1 
HETATM 3810 O  O   . HOH R 7 .   ? 11.07477  20.52323  -6.72914  1.000 46.33597 ? 459 HOH A O   1 
HETATM 3811 O  O   . HOH R 7 .   ? -2.44538  -5.80824  -4.98323  1.000 14.74694 ? 460 HOH A O   1 
HETATM 3812 O  O   . HOH R 7 .   ? -21.73502 -6.31994  13.55921  1.000 34.15389 ? 461 HOH A O   1 
HETATM 3813 O  O   . HOH R 7 .   ? 14.260    0.900     16.736    1.000 30.55868 ? 462 HOH A O   1 
HETATM 3814 O  O   . HOH R 7 .   ? -23.35114 -3.21722  -5.57940  1.000 26.35877 ? 463 HOH A O   1 
HETATM 3815 O  O   . HOH R 7 .   ? 5.76655   -15.03227 12.61898  1.000 20.99264 ? 464 HOH A O   1 
HETATM 3816 O  O   . HOH R 7 .   ? -27.48996 -3.37498  0.30138   1.000 33.92579 ? 465 HOH A O   1 
HETATM 3817 O  O   . HOH R 7 .   ? -2.93311  -15.39971 6.08409   1.000 12.04658 ? 466 HOH A O   1 
HETATM 3818 O  O   . HOH R 7 .   ? -18.17287 -7.22405  -12.26997 1.000 31.32656 ? 467 HOH A O   1 
HETATM 3819 O  O   . HOH R 7 .   ? 14.750    8.476     5.878     1.000 27.20383 ? 468 HOH A O   1 
HETATM 3820 O  O   . HOH R 7 .   ? 12.53374  -1.78681  14.38445  1.000 29.36630 ? 469 HOH A O   1 
HETATM 3821 O  O   . HOH R 7 .   ? -7.32065  2.48290   -3.52902  1.000 22.60624 ? 470 HOH A O   1 
HETATM 3822 O  O   . HOH R 7 .   ? -5.51802  -14.39342 -5.45512  1.000 32.35372 ? 471 HOH A O   1 
HETATM 3823 O  O   . HOH R 7 .   ? 15.51500  -6.20836  -16.37357 1.000 18.72432 ? 472 HOH A O   1 
HETATM 3824 O  O   . HOH R 7 .   ? -0.95027  -10.65149 -11.79991 1.000 10.51664 ? 473 HOH A O   1 
HETATM 3825 O  O   . HOH R 7 .   ? -15.11785 -5.41925  -0.19993  1.000 14.62033 ? 474 HOH A O   1 
HETATM 3826 O  O   . HOH R 7 .   ? -11.02811 -2.42473  -8.17428  1.000 9.86928  ? 475 HOH A O   1 
HETATM 3827 O  O   . HOH R 7 .   ? 7.60634   -18.08219 12.72401  1.000 40.94055 ? 476 HOH A O   1 
HETATM 3828 O  O   . HOH R 7 .   ? -17.55737 -6.97564  -3.25623  1.000 16.32528 ? 477 HOH A O   1 
HETATM 3829 O  O   . HOH R 7 .   ? 22.30052  -12.35769 -0.78891  1.000 40.36575 ? 478 HOH A O   1 
HETATM 3830 O  O   . HOH R 7 .   ? 2.92996   -3.13647  -2.28882  1.000 14.63219 ? 479 HOH A O   1 
HETATM 3831 O  O   . HOH R 7 .   ? -19.65824 3.83963   1.76617   1.000 25.51146 ? 480 HOH A O   1 
HETATM 3832 O  O   . HOH R 7 .   ? -18.50873 6.48630   -8.87261  1.000 35.34900 ? 481 HOH A O   1 
HETATM 3833 O  O   . HOH R 7 .   ? 5.51056   -12.92540 -14.07645 1.000 23.81058 ? 482 HOH A O   1 
HETATM 3834 O  O   . HOH R 7 .   ? -1.85030  -4.02836  -2.30732  1.000 18.17205 ? 483 HOH A O   1 
HETATM 3835 O  O   . HOH R 7 .   ? 1.25310   -19.93985 9.47822   1.000 26.06232 ? 484 HOH A O   1 
HETATM 3836 O  O   . HOH R 7 .   ? 1.12486   -10.71807 -9.27283  1.000 8.88842  ? 485 HOH A O   1 
HETATM 3837 O  O   . HOH R 7 .   ? -12.04697 -11.84252 -11.67608 1.000 22.77335 ? 486 HOH A O   1 
HETATM 3838 O  O   . HOH R 7 .   ? -8.26523  -1.64510  -13.60477 1.000 31.80881 ? 487 HOH A O   1 
HETATM 3839 O  O   . HOH R 7 .   ? -13.76278 -8.94142  2.61019   1.000 14.22519 ? 488 HOH A O   1 
HETATM 3840 O  O   . HOH R 7 .   ? -3.68904  -22.52760 3.77289   1.000 34.11832 ? 489 HOH A O   1 
HETATM 3841 O  O   . HOH R 7 .   ? -13.61444 3.45520   -10.78130 1.000 15.26765 ? 490 HOH A O   1 
HETATM 3842 O  O   . HOH R 7 .   ? 1.02974   -10.52849 -17.03313 1.000 10.13187 ? 491 HOH A O   1 
HETATM 3843 O  O   . HOH R 7 .   ? -8.06041  13.18970  8.61369   1.000 24.51295 ? 492 HOH A O   1 
HETATM 3844 O  O   . HOH R 7 .   ? -24.30510 -7.90878  -1.33568  1.000 32.61406 ? 493 HOH A O   1 
HETATM 3845 O  O   . HOH R 7 .   ? -13.99167 -3.35636  -1.65348  1.000 20.93544 ? 494 HOH A O   1 
HETATM 3846 O  O   . HOH R 7 .   ? -6.06396  -14.24617 -2.68234  1.000 21.46987 ? 495 HOH A O   1 
HETATM 3847 O  O   . HOH R 7 .   ? 5.65791   14.28316  10.11729  1.000 29.33034 ? 496 HOH A O   1 
HETATM 3848 O  O   . HOH R 7 .   ? 2.80412   14.68177  -7.38384  1.000 30.05742 ? 497 HOH A O   1 
HETATM 3849 O  O   . HOH R 7 .   ? 7.76118   -14.39757 16.11043  1.000 50.72036 ? 498 HOH A O   1 
HETATM 3850 O  O   . HOH R 7 .   ? 11.13104  -1.77205  2.17932   1.000 14.83807 ? 499 HOH A O   1 
HETATM 3851 O  O   . HOH R 7 .   ? -12.53184 8.24994   -1.09470  1.000 27.88327 ? 500 HOH A O   1 
HETATM 3852 O  O   . HOH R 7 .   ? 2.84885   17.29381  -10.26734 1.000 23.91267 ? 501 HOH A O   1 
HETATM 3853 O  O   . HOH R 7 .   ? 8.05054   4.21117   -7.39393  1.000 29.15135 ? 502 HOH A O   1 
HETATM 3854 O  O   . HOH R 7 .   ? -1.35953  -12.67596 15.83260  1.000 23.19345 ? 503 HOH A O   1 
HETATM 3855 O  O   . HOH R 7 .   ? -15.21575 9.01981   -3.60954  1.000 35.37636 ? 504 HOH A O   1 
HETATM 3856 O  O   . HOH R 7 .   ? 6.79559   16.67406  -1.87702  1.000 10.92830 ? 505 HOH A O   1 
HETATM 3857 O  O   . HOH R 7 .   ? -1.86236  -17.41726 4.51664   1.000 16.19892 ? 506 HOH A O   1 
HETATM 3858 O  O   . HOH R 7 .   ? 15.90434  -7.83771  5.32332   1.000 24.25447 ? 507 HOH A O   1 
HETATM 3859 O  O   . HOH R 7 .   ? -4.25596  9.33716   -6.20793  1.000 25.10526 ? 508 HOH A O   1 
HETATM 3860 O  O   . HOH R 7 .   ? 13.44671  -2.65118  12.04244  1.000 17.26823 ? 509 HOH A O   1 
HETATM 3861 O  O   . HOH R 7 .   ? -15.27574 -0.04589  -14.19859 1.000 31.75611 ? 510 HOH A O   1 
HETATM 3862 O  O   . HOH R 7 .   ? 3.60030   -15.92094 -10.58772 1.000 23.31676 ? 511 HOH A O   1 
HETATM 3863 O  O   . HOH R 7 .   ? 14.10253  9.64540   -3.08108  1.000 35.30159 ? 512 HOH A O   1 
HETATM 3864 O  O   . HOH R 7 .   ? 8.53650   22.06561  -11.45853 1.000 30.99017 ? 513 HOH A O   1 
HETATM 3865 O  O   . HOH R 7 .   ? 14.70307  -5.96165  10.92095  1.000 20.52781 ? 514 HOH A O   1 
HETATM 3866 O  O   . HOH R 7 .   ? -0.01579  -1.55682  -5.13562  1.000 20.01776 ? 515 HOH A O   1 
HETATM 3867 O  O   . HOH R 7 .   ? 12.27223  15.28145  5.09400   1.000 48.87110 ? 516 HOH A O   1 
HETATM 3868 O  O   . HOH R 7 .   ? -18.19323 7.54936   -4.08434  1.000 26.11987 ? 517 HOH A O   1 
HETATM 3869 O  O   . HOH R 7 .   ? -4.19512  -13.58294 -4.25727  1.000 22.12261 ? 518 HOH A O   1 
HETATM 3870 O  O   . HOH R 7 .   ? -1.98959  8.98601   19.79422  1.000 33.85081 ? 519 HOH A O   1 
HETATM 3871 O  O   . HOH R 7 .   ? -13.57122 -9.72753  5.21822   1.000 10.84469 ? 520 HOH A O   1 
HETATM 3872 O  O   . HOH R 7 .   ? 3.48940   -5.80172  -2.06093  1.000 12.30190 ? 521 HOH A O   1 
HETATM 3873 O  O   . HOH R 7 .   ? -15.85789 -3.82761  -13.75321 1.000 27.09684 ? 522 HOH A O   1 
HETATM 3874 O  O   . HOH R 7 .   ? -5.84603  -10.51017 10.21648  1.000 17.31826 ? 523 HOH A O   1 
HETATM 3875 O  O   . HOH R 7 .   ? 8.87625   -6.17932  -13.04052 1.000 17.45850 ? 524 HOH A O   1 
HETATM 3876 O  O   . HOH R 7 .   ? -20.41794 9.91549   11.56433  1.000 30.65032 ? 525 HOH A O   1 
HETATM 3877 O  O   . HOH R 7 .   ? -17.68133 -4.50813  -0.68906  1.000 12.53975 ? 526 HOH A O   1 
HETATM 3878 O  O   . HOH R 7 .   ? -21.92306 3.29520   6.30060   1.000 17.79345 ? 527 HOH A O   1 
HETATM 3879 O  O   . HOH R 7 .   ? 10.05021  -10.53272 -9.66098  1.000 15.66784 ? 528 HOH A O   1 
HETATM 3880 O  O   . HOH R 7 .   ? -16.82266 -13.52381 -5.23312  1.000 33.66824 ? 529 HOH A O   1 
HETATM 3881 O  O   . HOH R 7 .   ? 14.16618  0.35858   -6.64252  1.000 21.44559 ? 530 HOH A O   1 
HETATM 3882 O  O   . HOH R 7 .   ? 14.72405  -5.45725  6.65582   1.000 13.69221 ? 531 HOH A O   1 
HETATM 3883 O  O   . HOH R 7 .   ? -3.41875  11.09202  13.32357  1.000 30.96255 ? 532 HOH A O   1 
HETATM 3884 O  O   . HOH R 7 .   ? 7.95189   -7.12526  14.24683  1.000 29.22823 ? 533 HOH A O   1 
HETATM 3885 O  O   . HOH R 7 .   ? 10.70112  5.03870   14.36610  1.000 35.41166 ? 534 HOH A O   1 
HETATM 3886 O  O   . HOH R 7 .   ? -5.40677  -6.00188  19.71443  1.000 32.88277 ? 535 HOH A O   1 
HETATM 3887 O  O   . HOH R 7 .   ? 5.66591   -21.80353 5.61699   1.000 32.55075 ? 536 HOH A O   1 
HETATM 3888 O  O   . HOH R 7 .   ? 18.40785  -0.32499  -2.06417  1.000 34.40411 ? 537 HOH A O   1 
HETATM 3889 O  O   . HOH R 7 .   ? -23.37354 3.83221   -4.87540  1.000 26.55810 ? 538 HOH A O   1 
HETATM 3890 O  O   . HOH R 7 .   ? -4.96049  16.49228  5.62770   1.000 26.06954 ? 539 HOH A O   1 
HETATM 3891 O  O   . HOH R 7 .   ? -21.79775 -8.19445  4.06389   1.000 28.35868 ? 540 HOH A O   1 
HETATM 3892 O  O   . HOH R 7 .   ? -4.05324  -2.62063  -15.45425 1.000 22.83610 ? 541 HOH A O   1 
HETATM 3893 O  O   . HOH R 7 .   ? 0.28320   -2.11124  -2.42877  1.000 17.44071 ? 542 HOH A O   1 
HETATM 3894 O  O   . HOH R 7 .   ? -6.27175  0.80764   -4.52576  1.000 23.69326 ? 543 HOH A O   1 
HETATM 3895 O  O   . HOH R 7 .   ? -8.49602  -11.54074 13.03162  1.000 29.78403 ? 544 HOH A O   1 
HETATM 3896 O  O   . HOH R 7 .   ? 15.39943  -7.39993  -9.13352  1.000 14.48504 ? 545 HOH A O   1 
HETATM 3897 O  O   . HOH R 7 .   ? -7.05492  9.55600   0.25482   1.000 13.74724 ? 546 HOH A O   1 
HETATM 3898 O  O   . HOH R 7 .   ? 15.31752  2.80663   -4.35859  1.000 28.86842 ? 547 HOH A O   1 
HETATM 3899 O  O   . HOH R 7 .   ? 6.89767   -14.05582 -8.74583  1.000 22.32350 ? 548 HOH A O   1 
HETATM 3900 O  O   . HOH R 7 .   ? 3.23407   -16.48982 -1.53726  1.000 23.01606 ? 549 HOH A O   1 
HETATM 3901 O  O   . HOH R 7 .   ? -4.88189  16.98392  -0.41126  1.000 38.15498 ? 550 HOH A O   1 
HETATM 3902 O  O   . HOH R 7 .   ? -11.11791 1.08259   4.72692   1.000 12.14584 ? 551 HOH A O   1 
HETATM 3903 O  O   . HOH R 7 .   ? -12.70459 -1.88204  -0.50663  1.000 21.31163 ? 552 HOH A O   1 
HETATM 3904 O  O   . HOH R 7 .   ? -14.03155 12.36950  6.70913   1.000 28.34067 ? 553 HOH A O   1 
HETATM 3905 O  O   . HOH R 7 .   ? -15.31031 -13.16889 7.26369   1.000 22.14931 ? 554 HOH A O   1 
HETATM 3906 O  O   . HOH R 7 .   ? -11.85485 -10.72397 -1.80026  1.000 17.92032 ? 555 HOH A O   1 
HETATM 3907 O  O   . HOH R 7 .   ? 6.08596   4.32402   -8.29958  1.000 25.41142 ? 556 HOH A O   1 
HETATM 3908 O  O   . HOH R 7 .   ? -11.85698 13.72233  8.86062   1.000 30.42568 ? 557 HOH A O   1 
HETATM 3909 O  O   . HOH R 7 .   ? -24.55873 -3.97295  1.10108   1.000 30.47347 ? 558 HOH A O   1 
HETATM 3910 O  O   . HOH R 7 .   ? -0.85256  18.74303  2.74922   1.000 30.54847 ? 559 HOH A O   1 
HETATM 3911 O  O   . HOH R 7 .   ? 8.35915   -11.39661 15.85189  1.000 36.30694 ? 560 HOH A O   1 
HETATM 3912 O  O   . HOH R 7 .   ? 8.66604   -9.57547  11.90005  1.000 27.75945 ? 561 HOH A O   1 
HETATM 3913 O  O   . HOH R 7 .   ? 3.33561   9.01139   -10.59196 1.000 23.48759 ? 562 HOH A O   1 
HETATM 3914 O  O   . HOH R 7 .   ? 0.72219   21.68987  -2.90849  1.000 27.77295 ? 563 HOH A O   1 
HETATM 3915 O  O   . HOH R 7 .   ? -12.99742 -15.14886 -2.62529  1.000 29.08282 ? 564 HOH A O   1 
HETATM 3916 O  O   . HOH R 7 .   ? -6.46540  13.93059  -1.14717  1.000 30.15710 ? 565 HOH A O   1 
HETATM 3917 O  O   . HOH R 7 .   ? 3.60070   -5.28763  -12.58815 1.000 15.94536 ? 566 HOH A O   1 
HETATM 3918 O  O   . HOH R 7 .   ? 12.76093  -15.33659 -1.95867  1.000 27.13153 ? 567 HOH A O   1 
HETATM 3919 O  O   . HOH R 7 .   ? 16.47404  -5.02094  2.69169   1.000 39.24114 ? 568 HOH A O   1 
HETATM 3920 O  O   . HOH R 7 .   ? 10.17910  -12.47860 -15.49621 1.000 21.11463 ? 569 HOH A O   1 
HETATM 3921 O  O   . HOH R 7 .   ? -24.17017 8.57342   -1.52788  1.000 48.89733 ? 570 HOH A O   1 
HETATM 3922 O  O   . HOH R 7 .   ? -6.17204  -13.05792 -7.25317  1.000 17.28697 ? 571 HOH A O   1 
HETATM 3923 O  O   . HOH R 7 .   ? -11.00532 10.28407  20.26820  1.000 30.57473 ? 572 HOH A O   1 
HETATM 3924 O  O   . HOH R 7 .   ? -7.98128  7.15549   -13.51357 1.000 43.31484 ? 573 HOH A O   1 
HETATM 3925 O  O   . HOH R 7 .   ? -8.82543  10.31903  13.81862  1.000 19.00486 ? 574 HOH A O   1 
HETATM 3926 O  O   . HOH R 7 .   ? 5.96549   -6.02101  -0.58513  1.000 8.89524  ? 575 HOH A O   1 
HETATM 3927 O  O   . HOH R 7 .   ? -13.82692 7.03722   2.58366   1.000 29.84655 ? 576 HOH A O   1 
HETATM 3928 O  O   . HOH R 7 .   ? -0.59056  -9.18887  14.41117  1.000 24.75549 ? 577 HOH A O   1 
HETATM 3929 O  O   . HOH R 7 .   ? 1.91987   14.33774  -5.21090  1.000 32.69900 ? 578 HOH A O   1 
HETATM 3930 O  O   . HOH R 7 .   ? -4.04052  6.76705   21.34242  1.000 40.43181 ? 579 HOH A O   1 
HETATM 3931 O  O   . HOH R 7 .   ? 12.010    0.694     19.904    1.000 42.59802 ? 580 HOH A O   1 
HETATM 3932 O  O   . HOH R 7 .   ? 6.27039   -6.36673  -13.53237 1.000 17.65600 ? 581 HOH A O   1 
HETATM 3933 O  O   . HOH R 7 .   ? -19.506   11.450    16.014    1.000 17.96043 ? 582 HOH A O   1 
HETATM 3934 O  O   . HOH R 7 .   ? 13.238    -0.281    18.894    1.000 27.15676 ? 583 HOH A O   1 
HETATM 3935 O  O   . HOH R 7 .   ? -13.78879 -11.38460 14.10175  1.000 27.94059 ? 584 HOH A O   1 
HETATM 3936 O  O   . HOH R 7 .   ? -15.96239 -3.99762  15.87363  1.000 19.23369 ? 585 HOH A O   1 
HETATM 3937 O  O   . HOH R 7 .   ? -23.57403 0.03186   7.21554   1.000 29.67028 ? 586 HOH A O   1 
HETATM 3938 O  O   . HOH R 7 .   ? 10.72245  -3.64759  15.66465  1.000 36.86682 ? 587 HOH A O   1 
HETATM 3939 O  O   . HOH R 7 .   ? 5.42639   -17.01759 -2.85842  1.000 26.63625 ? 588 HOH A O   1 
HETATM 3940 O  O   . HOH R 7 .   ? -18.33634 -9.52410  -3.12161  1.000 23.57624 ? 589 HOH A O   1 
HETATM 3941 O  O   . HOH R 7 .   ? -21.43889 -9.89816  1.83770   1.000 29.53258 ? 590 HOH A O   1 
HETATM 3942 O  O   . HOH R 7 .   ? 8.69625   9.36475   12.19072  1.000 22.40579 ? 591 HOH A O   1 
HETATM 3943 O  O   . HOH R 7 .   ? -6.74386  -15.75688 12.67247  1.000 45.23543 ? 592 HOH A O   1 
HETATM 3944 O  O   . HOH R 7 .   ? 0.95714   -10.82177 16.30491  1.000 22.03594 ? 593 HOH A O   1 
HETATM 3945 O  O   . HOH R 7 .   ? 16.50119  5.07622   1.89401   1.000 29.81647 ? 594 HOH A O   1 
HETATM 3946 O  O   . HOH R 7 .   ? -9.25875  -15.91189 -5.24604  1.000 26.41934 ? 595 HOH A O   1 
HETATM 3947 O  O   . HOH R 7 .   ? -17.19707 -14.77061 5.12285   1.000 25.16226 ? 596 HOH A O   1 
HETATM 3948 O  O   . HOH R 7 .   ? 9.50827   -3.56224  -12.68595 1.000 32.13894 ? 597 HOH A O   1 
HETATM 3949 O  O   . HOH R 7 .   ? -9.70648  -17.15191 7.40115   1.000 31.19623 ? 598 HOH A O   1 
HETATM 3950 O  O   . HOH R 7 .   ? -25.23327 4.92725   -10.19643 1.000 54.38117 ? 599 HOH A O   1 
HETATM 3951 O  O   . HOH R 7 .   ? 12.83189  -4.26775  -0.63024  1.000 21.08231 ? 600 HOH A O   1 
HETATM 3952 O  O   . HOH R 7 .   ? -13.08659 6.40700   -10.29307 1.000 16.58134 ? 601 HOH A O   1 
HETATM 3953 O  O   . HOH R 7 .   ? -1.44171  15.01595  10.35135  1.000 37.87806 ? 602 HOH A O   1 
HETATM 3954 O  O   . HOH R 7 .   ? 18.09298  -16.41728 -10.31216 1.000 40.48194 ? 603 HOH A O   1 
HETATM 3955 O  O   . HOH R 7 .   ? -14.94539 9.27053   1.67586   1.000 32.65620 ? 604 HOH A O   1 
HETATM 3956 O  O   . HOH R 7 .   ? 11.50228  1.90272   -9.02961  1.000 16.93761 ? 605 HOH A O   1 
HETATM 3957 O  O   . HOH R 7 .   ? 10.53261  18.26500  -2.33365  1.000 39.04779 ? 606 HOH A O   1 
HETATM 3958 O  O   . HOH R 7 .   ? -3.57020  7.98308   -8.82450  1.000 31.03515 ? 607 HOH A O   1 
HETATM 3959 O  O   . HOH R 7 .   ? 7.79533   3.17415   17.84765  1.000 23.21175 ? 608 HOH A O   1 
HETATM 3960 O  O   . HOH R 7 .   ? -10.60345 -7.56381  19.00773  1.000 23.27011 ? 609 HOH A O   1 
HETATM 3961 O  O   . HOH R 7 .   ? -4.69677  3.57001   -4.99359  1.000 23.62107 ? 610 HOH A O   1 
HETATM 3962 O  O   . HOH R 7 .   ? 14.20380  12.00210  3.65279   1.000 22.15582 ? 611 HOH A O   1 
HETATM 3963 O  O   . HOH R 7 .   ? -12.33319 -15.83191 7.39960   1.000 45.09762 ? 612 HOH A O   1 
HETATM 3964 O  O   . HOH R 7 .   ? 9.947     2.107     19.579    1.000 35.57047 ? 613 HOH A O   1 
HETATM 3965 O  O   . HOH R 7 .   ? 0.09774   3.73423   -14.18841 1.000 36.58702 ? 614 HOH A O   1 
HETATM 3966 O  O   . HOH R 7 .   ? -16.72007 -13.30948 -1.66729  1.000 27.33067 ? 615 HOH A O   1 
HETATM 3967 O  O   . HOH R 7 .   ? -26.83773 1.71338   -12.01483 1.000 45.86660 ? 616 HOH A O   1 
HETATM 3968 O  O   . HOH R 7 .   ? 13.43396  12.89878  -0.08133  1.000 29.36841 ? 617 HOH A O   1 
HETATM 3969 O  O   . HOH R 7 .   ? 1.02758   -18.64130 16.21768  1.000 38.69245 ? 618 HOH A O   1 
HETATM 3970 O  O   . HOH R 7 .   ? -2.74885  -21.03440 -1.14699  1.000 36.90213 ? 619 HOH A O   1 
HETATM 3971 O  O   . HOH R 7 .   ? -0.55890  -19.27587 -6.45482  1.000 22.94518 ? 620 HOH A O   1 
HETATM 3972 O  O   . HOH R 7 .   ? 11.61745  -10.73006 10.00600  1.000 32.49133 ? 621 HOH A O   1 
HETATM 3973 O  O   . HOH R 7 .   ? 6.34190   15.48593  14.32232  1.000 44.25934 ? 622 HOH A O   1 
HETATM 3974 O  O   . HOH R 7 .   ? -9.48358  14.71658  6.90289   1.000 34.45280 ? 623 HOH A O   1 
HETATM 3975 O  O   . HOH R 7 .   ? -8.76909  -14.44993 -11.83031 1.000 34.50602 ? 624 HOH A O   1 
HETATM 3976 O  O   . HOH R 7 .   ? -15.16219 6.74571   -1.30819  1.000 37.10669 ? 625 HOH A O   1 
HETATM 3977 O  O   . HOH R 7 .   ? 13.16120  4.52987   6.79829   1.000 40.73481 ? 626 HOH A O   1 
HETATM 3978 O  O   . HOH R 7 .   ? -8.39273  6.94648   28.94647  1.000 40.59267 ? 627 HOH A O   1 
HETATM 3979 O  O   . HOH R 7 .   ? -6.24960  -7.80258  19.41120  1.000 53.88798 ? 628 HOH A O   1 
HETATM 3980 O  O   . HOH R 7 .   ? -16.14791 5.70948   0.14459   1.000 28.55099 ? 629 HOH A O   1 
HETATM 3981 O  O   . HOH R 7 .   ? -5.28299  -0.43321  -16.72835 1.000 22.69666 ? 630 HOH A O   1 
HETATM 3982 O  O   . HOH R 7 .   ? -6.81029  -21.36002 0.37887   1.000 34.46575 ? 631 HOH A O   1 
HETATM 3983 O  O   . HOH R 7 .   ? -13.29328 -14.28130 6.03025   1.000 24.48808 ? 632 HOH A O   1 
HETATM 3984 O  O   . HOH R 7 .   ? -23.53239 4.35973   -15.20338 1.000 46.99469 ? 633 HOH A O   1 
HETATM 3985 O  O   . HOH R 7 .   ? -21.30666 5.58533   11.12885  1.000 20.76477 ? 634 HOH A O   1 
HETATM 3986 O  O   . HOH R 7 .   ? 8.793     22.738    -7.639    1.000 32.81706 ? 635 HOH A O   1 
HETATM 3987 O  O   . HOH R 7 .   ? 16.03418  1.12751   -4.90889  1.000 41.94070 ? 636 HOH A O   1 
HETATM 3988 O  O   . HOH R 7 .   ? 3.39365   -21.41065 13.64215  1.000 37.99607 ? 637 HOH A O   1 
HETATM 3989 O  O   . HOH R 7 .   ? -19.35095 7.31458   1.68555   1.000 39.35652 ? 638 HOH A O   1 
HETATM 3990 O  O   . HOH R 7 .   ? -23.09269 -5.74326  2.76777   1.000 35.56546 ? 639 HOH A O   1 
HETATM 3991 O  O   . HOH R 7 .   ? 16.05513  7.31005   1.01661   1.000 28.01762 ? 640 HOH A O   1 
HETATM 3992 O  O   . HOH R 7 .   ? -19.46452 4.42734   -1.13521  1.000 23.64713 ? 641 HOH A O   1 
HETATM 3993 O  O   . HOH R 7 .   ? 14.85793  12.04555  6.20587   1.000 46.03926 ? 642 HOH A O   1 
HETATM 3994 O  O   . HOH R 7 .   ? 1.06787   -2.80906  -13.40346 1.000 20.75201 ? 643 HOH A O   1 
HETATM 3995 O  O   . HOH R 7 .   ? -2.98964  -22.63161 1.14403   1.000 42.69214 ? 644 HOH A O   1 
HETATM 3996 O  O   . HOH R 7 .   ? 18.72491  -7.08388  -10.42505 1.000 47.12262 ? 645 HOH A O   1 
HETATM 3997 O  O   . HOH R 7 .   ? 13.07602  5.16712   9.29111   1.000 35.88321 ? 646 HOH A O   1 
HETATM 3998 O  O   . HOH R 7 .   ? 13.24813  -16.95961 -1.29647  1.000 41.36223 ? 647 HOH A O   1 
HETATM 3999 O  O   . HOH R 7 .   ? 9.03805   9.86135   15.09717  1.000 39.59775 ? 648 HOH A O   1 
HETATM 4000 O  O   . HOH R 7 .   ? 1.25944   -12.48902 -15.50783 1.000 23.41224 ? 649 HOH A O   1 
HETATM 4001 O  O   . HOH R 7 .   ? 4.28117   12.95608  -9.14566  1.000 42.19618 ? 650 HOH A O   1 
HETATM 4002 O  O   . HOH R 7 .   ? 15.175    3.524     13.128    1.000 28.68698 ? 651 HOH A O   1 
HETATM 4003 O  O   . HOH R 7 .   ? -8.35620  -14.16055 12.93415  1.000 36.76039 ? 652 HOH A O   1 
HETATM 4004 O  O   . HOH R 7 .   ? 0.77378   -22.56804 10.47905  1.000 48.28550 ? 653 HOH A O   1 
HETATM 4005 O  O   . HOH R 7 .   ? -26.68122 -0.08881  -3.69589  1.000 37.14157 ? 654 HOH A O   1 
HETATM 4006 O  O   . HOH R 7 .   ? -9.88605  12.60534  17.22735  1.000 50.37339 ? 655 HOH A O   1 
HETATM 4007 O  O   . HOH R 7 .   ? -10.71620 14.17562  16.19410  1.000 41.87549 ? 656 HOH A O   1 
HETATM 4008 O  O   . HOH R 7 .   ? 6.96907   -21.32958 12.23852  1.000 41.73003 ? 657 HOH A O   1 
HETATM 4009 O  O   . HOH R 7 .   ? -2.42154  -15.10387 16.13871  1.000 52.41030 ? 658 HOH A O   1 
HETATM 4010 O  O   . HOH R 7 .   ? -19.21224 -11.37044 -8.57656  1.000 48.62445 ? 659 HOH A O   1 
HETATM 4011 O  O   . HOH R 7 .   ? 15.56151  4.15980   11.44711  1.000 33.26785 ? 660 HOH A O   1 
HETATM 4012 O  O   . HOH R 7 .   ? -21.72571 3.36154   -17.32951 1.000 42.82768 ? 661 HOH A O   1 
HETATM 4013 O  O   . HOH R 7 .   ? 10.56993  -11.92168 16.36411  1.000 47.35005 ? 662 HOH A O   1 
HETATM 4014 O  O   . HOH R 7 .   ? 15.026    2.771     15.564    1.000 30.26608 ? 663 HOH A O   1 
HETATM 4015 O  O   . HOH R 7 .   ? 17.23880  -5.83488  -11.37771 1.000 30.04863 ? 664 HOH A O   1 
HETATM 4016 O  O   . HOH R 7 .   ? 12.87429  19.09539  -6.62515  1.000 44.61934 ? 665 HOH A O   1 
HETATM 4017 O  O   . HOH R 7 .   ? -6.03096  11.20784  -6.13515  1.000 35.22297 ? 666 HOH A O   1 
HETATM 4018 O  O   . HOH R 7 .   ? -8.58190  -8.53006  19.58722  1.000 48.04799 ? 667 HOH A O   1 
HETATM 4019 O  O   . HOH R 7 .   ? 8.737     20.028    -3.896    1.000 34.20858 ? 668 HOH A O   1 
HETATM 4020 O  O   . HOH R 7 .   ? 14.24274  7.47341   -3.44478  1.000 29.80873 ? 669 HOH A O   1 
HETATM 4021 O  O   . HOH R 7 .   ? -22.94897 5.20041   -7.55780  1.000 40.67178 ? 670 HOH A O   1 
HETATM 4022 O  O   . HOH R 7 .   ? 0.14693   -24.25491 9.38533   1.000 53.98343 ? 671 HOH A O   1 
HETATM 4023 O  O   . HOH R 7 .   ? 13.66988  -8.21220  12.27351  1.000 23.81128 ? 672 HOH A O   1 
HETATM 4024 O  O   . HOH R 7 .   ? 8.28233   -9.74255  13.60379  1.000 35.05567 ? 673 HOH A O   1 
HETATM 4025 O  O   . HOH R 7 .   ? -20.03860 -5.84424  11.97571  1.000 34.95163 ? 674 HOH A O   1 
HETATM 4026 O  O   . HOH R 7 .   ? -19.27738 -6.59750  -14.25764 1.000 40.23319 ? 675 HOH A O   1 
HETATM 4027 O  O   . HOH R 7 .   ? 4.83870   -18.52411 -3.52018  1.000 48.64582 ? 676 HOH A O   1 
HETATM 4028 O  O   . HOH R 7 .   ? -9.78504  8.11907   -13.82040 1.000 36.86908 ? 677 HOH A O   1 
HETATM 4029 O  O   . HOH R 7 .   ? -13.26180 -14.16281 -11.04539 1.000 39.06188 ? 678 HOH A O   1 
HETATM 4030 O  O   . HOH R 7 .   ? -17.47814 7.51176   0.49813   1.000 52.87108 ? 679 HOH A O   1 
HETATM 4031 O  O   . HOH R 7 .   ? -8.41013  5.79564   -15.22051 1.000 34.08724 ? 680 HOH A O   1 
HETATM 4032 O  O   . HOH R 7 .   ? -5.33296  -20.66323 -2.29866  1.000 37.32613 ? 681 HOH A O   1 
HETATM 4033 O  O   . HOH R 7 .   ? 16.60970  -10.54117 -17.68653 1.000 34.32236 ? 682 HOH A O   1 
HETATM 4034 O  O   . HOH R 7 .   ? -25.66422 2.35905   -4.79141  1.000 35.27889 ? 683 HOH A O   1 
HETATM 4035 O  O   . HOH R 7 .   ? -7.87748  11.56078  -1.28865  1.000 28.85744 ? 684 HOH A O   1 
HETATM 4036 O  O   . HOH R 7 .   ? -16.76161 -14.23389 -7.72237  1.000 40.39990 ? 685 HOH A O   1 
HETATM 4037 O  O   . HOH R 7 .   ? -7.41374  9.30895   28.06097  1.000 47.64508 ? 686 HOH A O   1 
HETATM 4038 O  O   . HOH R 7 .   ? 3.827     22.276    1.790     1.000 35.36790 ? 687 HOH A O   1 
HETATM 4039 O  O   . HOH R 7 .   ? 1.01408   -6.99264  20.53312  1.000 47.19727 ? 688 HOH A O   1 
HETATM 4040 O  O   . HOH R 7 .   ? -4.60379  13.18739  13.18667  1.000 38.46210 ? 689 HOH A O   1 
HETATM 4041 O  O   . HOH R 7 .   ? 7.509     19.539    -1.421    1.000 18.82143 ? 690 HOH A O   1 
HETATM 4042 O  O   . HOH R 7 .   ? -23.46591 9.64686   -2.91539  1.000 52.88515 ? 691 HOH A O   1 
HETATM 4043 O  O   . HOH R 7 .   ? 5.34395   -22.55362 12.62562  1.000 42.02132 ? 692 HOH A O   1 
HETATM 4044 O  O   . HOH R 7 .   ? 9.80372   -12.72763 -10.36410 1.000 28.88819 ? 693 HOH A O   1 
HETATM 4045 O  O   . HOH R 7 .   ? 4.04280   6.66783   -12.74787 1.000 28.98847 ? 694 HOH A O   1 
HETATM 4046 O  O   . HOH R 7 .   ? -18.62442 8.11548   -6.69866  1.000 33.68857 ? 695 HOH A O   1 
HETATM 4047 O  O   . HOH R 7 .   ? 15.729    6.249     6.632     1.000 34.84146 ? 696 HOH A O   1 
HETATM 4048 O  O   . HOH R 7 .   ? 8.50894   -14.16572 13.49012  1.000 31.71071 ? 697 HOH A O   1 
HETATM 4049 O  O   . HOH R 7 .   ? 2.73297   -21.83874 11.18008  1.000 43.37886 ? 698 HOH A O   1 
HETATM 4050 O  O   . HOH R 7 .   ? 0.09285   -4.08114  24.19905  1.000 37.39920 ? 699 HOH A O   1 
HETATM 4051 O  O   . HOH R 7 .   ? -22.67654 -7.59325  7.28476   1.000 36.31039 ? 700 HOH A O   1 
HETATM 4052 O  O   . HOH R 7 .   ? -18.82284 -14.04092 -4.81233  1.000 48.45695 ? 701 HOH A O   1 
HETATM 4053 O  O   . HOH R 7 .   ? -6.44898  -19.59126 -4.40322  1.000 33.33225 ? 702 HOH A O   1 
HETATM 4054 O  O   . HOH R 7 .   ? -7.02697  -16.88469 -5.34179  1.000 28.10264 ? 703 HOH A O   1 
HETATM 4055 O  O   . HOH R 7 .   ? 10.05866  19.65909  -0.71386  1.000 52.93966 ? 704 HOH A O   1 
HETATM 4056 O  O   . HOH R 7 .   ? -27.00261 5.65074   -11.58912 1.000 48.13888 ? 705 HOH A O   1 
HETATM 4057 O  O   . HOH R 7 .   ? -19.50030 -14.67268 6.65469   1.000 37.34514 ? 706 HOH A O   1 
HETATM 4058 O  O   . HOH R 7 .   ? -26.53781 1.80827   -6.97061  1.000 46.41590 ? 707 HOH A O   1 
HETATM 4059 O  O   . HOH R 7 .   ? 5.676     16.814    -12.079   1.000 36.35646 ? 708 HOH A O   1 
HETATM 4060 O  O   . HOH R 7 .   ? -7.62866  12.04439  -3.59874  1.000 36.16738 ? 709 HOH A O   1 
HETATM 4061 O  O   . HOH R 7 .   ? 11.46933  -13.69809 -13.33349 1.000 31.70766 ? 710 HOH A O   1 
HETATM 4062 O  O   . HOH R 7 .   ? 10.99771  9.33465   11.24392  1.000 34.14604 ? 711 HOH A O   1 
HETATM 4063 O  O   . HOH R 7 .   ? 7.660     20.388    1.578     1.000 36.56471 ? 712 HOH A O   1 
HETATM 4064 O  O   . HOH R 7 .   ? -5.40366  -9.45518  20.73856  1.000 34.27639 ? 713 HOH A O   1 
HETATM 4065 O  O   . HOH R 7 .   ? 6.63098   -23.11594 7.51690   1.000 46.16909 ? 714 HOH A O   1 
HETATM 4066 O  O   . HOH R 7 .   ? 1.576     21.286    0.262     1.000 26.06981 ? 715 HOH A O   1 
HETATM 4067 O  O   . HOH R 7 .   ? 12.46896  6.92382   9.89043   1.000 38.80428 ? 716 HOH A O   1 
HETATM 4068 O  O   . HOH R 7 .   ? -11.08056 10.52553  23.30957  1.000 39.94583 ? 717 HOH A O   1 
HETATM 4069 O  O   . HOH R 7 .   ? -22.00128 10.43431  9.26275   1.000 42.54898 ? 718 HOH A O   1 
HETATM 4070 O  O   . HOH R 7 .   ? -2.36506  -19.68315 -10.24730 1.000 39.02032 ? 719 HOH A O   1 
HETATM 4071 O  O   . HOH R 7 .   ? -28.93613 1.31866   -11.37455 1.000 50.89825 ? 720 HOH A O   1 
HETATM 4072 O  O   . HOH R 7 .   ? -18.364   -4.796    22.719    1.000 43.40089 ? 721 HOH A O   1 
HETATM 4073 O  O   . HOH R 7 .   ? -20.67123 11.62487  7.92636   1.000 46.85686 ? 722 HOH A O   1 
HETATM 4074 O  O   . HOH R 7 .   ? 5.821     14.829    -12.822   1.000 46.48814 ? 723 HOH A O   1 
HETATM 4075 O  O   . HOH R 7 .   ? -27.01787 6.63888   -10.02161 1.000 41.61583 ? 724 HOH A O   1 
HETATM 4076 O  O   . HOH R 7 .   ? -14.55600 -15.55416 -9.61630  1.000 43.34828 ? 725 HOH A O   1 
HETATM 4077 O  O   . HOH R 7 .   ? 7.50837   -22.70657 9.86318   1.000 46.13533 ? 726 HOH A O   1 
HETATM 4078 O  O   . HOH R 7 .   ? -6.29275  -7.36051  23.24717  1.000 38.46837 ? 727 HOH A O   1 
HETATM 4079 O  O   . HOH R 7 .   ? -9.25158  -10.45472 21.83102  1.000 41.10695 ? 728 HOH A O   1 
HETATM 4080 O  O   . HOH R 7 .   ? 4.66823   -5.97990  24.99681  1.000 46.73602 ? 729 HOH A O   1 
HETATM 4081 O  O   . HOH R 7 .   ? -25.49034 8.94361   -10.41181 1.000 40.68009 ? 730 HOH A O   1 
HETATM 4082 O  O   . HOH R 7 .   ? -30.21776 -0.46476  -12.52949 1.000 50.77974 ? 731 HOH A O   1 
HETATM 4083 O  O   . HOH R 7 .   ? -4.15824  -7.00553  24.53167  1.000 39.15771 ? 732 HOH A O   1 
HETATM 4084 O  O   . HOH R 7 .   ? -21.80921 9.67218   -6.98700  1.000 56.21200 ? 733 HOH A O   1 
HETATM 4085 O  O   . HOH R 7 .   ? -22.04646 9.61917   -9.49056  1.000 48.62354 ? 734 HOH A O   1 
HETATM 4086 O  O   . HOH R 7 .   ? -2.72468  -8.20217  26.36407  1.000 48.82783 ? 735 HOH A O   1 
HETATM 4087 O  O   . HOH R 7 .   ? -1.26242  -7.64400  27.66819  1.000 47.70882 ? 736 HOH A O   1 
HETATM 4088 O  O   . HOH R 7 .   ? 0.03176   -6.34362  30.09417  1.000 40.54837 ? 737 HOH A O   1 
HETATM 4089 O  O   . HOH S 7 .   ? -10.09464 15.40747  -35.74139 1.000 36.05318 ? 401 HOH B O   1 
HETATM 4090 O  O   . HOH S 7 .   ? 17.08746  12.47993  -43.49622 1.000 34.74144 ? 402 HOH B O   1 
HETATM 4091 O  O   . HOH S 7 .   ? 14.53443  2.99432   -15.25787 1.000 31.74000 ? 403 HOH B O   1 
HETATM 4092 O  O   . HOH S 7 .   ? 21.42749  -5.48952  -23.63768 1.000 25.93389 ? 404 HOH B O   1 
HETATM 4093 O  O   . HOH S 7 .   ? -2.72404  -7.68640  -46.82401 1.000 31.00159 ? 405 HOH B O   1 
HETATM 4094 O  O   . HOH S 7 .   ? -11.27033 -14.36398 -23.68177 1.000 25.76329 ? 406 HOH B O   1 
HETATM 4095 O  O   . HOH S 7 .   ? -0.00987  1.02915   -23.90823 1.000 30.24625 ? 407 HOH B O   1 
HETATM 4096 O  O   . HOH S 7 .   ? 25.20340  2.80158   -30.30031 1.000 37.40060 ? 408 HOH B O   1 
HETATM 4097 O  O   . HOH S 7 .   ? -8.09032  7.66733   -44.28563 1.000 34.09584 ? 409 HOH B O   1 
HETATM 4098 O  O   . HOH S 7 .   ? -11.52036 3.24451   -42.34661 1.000 24.34940 ? 410 HOH B O   1 
HETATM 4099 O  O   . HOH S 7 .   ? -5.12581  -16.74757 -26.04275 1.000 24.56419 ? 411 HOH B O   1 
HETATM 4100 O  O   . HOH S 7 .   ? 22.58831  -3.86207  -20.74226 1.000 54.73468 ? 412 HOH B O   1 
HETATM 4101 O  O   . HOH S 7 .   ? 0.80360   15.72178  -41.91123 1.000 34.71724 ? 413 HOH B O   1 
HETATM 4102 O  O   . HOH S 7 .   ? 15.27871  10.58712  -30.10867 1.000 41.47637 ? 414 HOH B O   1 
HETATM 4103 O  O   . HOH S 7 .   ? 0.01348   20.50017  -25.51261 1.000 33.24676 ? 415 HOH B O   1 
HETATM 4104 O  O   . HOH S 7 .   ? -12.30594 -15.43379 -26.95576 1.000 23.16882 ? 416 HOH B O   1 
HETATM 4105 O  O   . HOH S 7 .   ? 4.84998   -15.93540 -21.39826 1.000 28.09417 ? 417 HOH B O   1 
HETATM 4106 O  O   . HOH S 7 .   ? -12.95212 -9.38874  -36.58078 1.000 21.38458 ? 418 HOH B O   1 
HETATM 4107 O  O   . HOH S 7 .   ? -16.41485 -9.80176  -34.67829 1.000 46.95952 ? 419 HOH B O   1 
HETATM 4108 O  O   . HOH S 7 .   ? 15.84674  4.80926   -53.80685 1.000 42.15651 ? 420 HOH B O   1 
HETATM 4109 O  O   . HOH S 7 .   ? 5.57000   -4.82983  -47.36292 1.000 37.52542 ? 421 HOH B O   1 
HETATM 4110 O  O   . HOH S 7 .   ? -20.29174 -5.36324  -22.56833 1.000 39.48307 ? 422 HOH B O   1 
HETATM 4111 O  O   . HOH S 7 .   ? -7.58720  20.51538  -29.76664 1.000 34.78140 ? 423 HOH B O   1 
HETATM 4112 O  O   . HOH S 7 .   ? -11.05442 20.34472  -16.90511 1.000 36.94229 ? 424 HOH B O   1 
HETATM 4113 O  O   . HOH S 7 .   ? 3.84974   -21.69780 -33.21119 1.000 41.66770 ? 425 HOH B O   1 
HETATM 4114 O  O   . HOH S 7 .   ? 7.85366   -16.16259 -20.66899 1.000 36.53701 ? 426 HOH B O   1 
HETATM 4115 O  O   . HOH S 7 .   ? -3.09774  11.14878  -44.16956 1.000 29.31114 ? 427 HOH B O   1 
HETATM 4116 O  O   . HOH S 7 .   ? 1.08300   2.59681   -28.98236 1.000 14.13539 ? 428 HOH B O   1 
HETATM 4117 O  O   . HOH S 7 .   ? 23.38908  4.09151   -23.58230 1.000 26.63883 ? 429 HOH B O   1 
HETATM 4118 O  O   . HOH S 7 .   ? 13.98297  12.96318  -35.01518 1.000 31.82090 ? 430 HOH B O   1 
HETATM 4119 O  O   . HOH S 7 .   ? 5.45895   -14.11758 -23.63060 1.000 25.03988 ? 431 HOH B O   1 
HETATM 4120 O  O   . HOH S 7 .   ? 21.68538  3.03390   -31.40634 1.000 27.65539 ? 432 HOH B O   1 
HETATM 4121 O  O   . HOH S 7 .   ? -12.56331 -0.73003  -43.09482 1.000 28.46411 ? 433 HOH B O   1 
HETATM 4122 O  O   . HOH S 7 .   ? 18.32323  -7.05274  -16.64279 1.000 30.58752 ? 434 HOH B O   1 
HETATM 4123 O  O   . HOH S 7 .   ? 21.40306  0.93800   -29.68601 1.000 18.80956 ? 435 HOH B O   1 
HETATM 4124 O  O   . HOH S 7 .   ? 8.88221   -13.69196 -20.88528 1.000 28.57108 ? 436 HOH B O   1 
HETATM 4125 O  O   . HOH S 7 .   ? 18.18901  7.75344   -24.57961 1.000 28.90398 ? 437 HOH B O   1 
HETATM 4126 O  O   . HOH S 7 .   ? 5.91946   -4.92266  -15.91587 1.000 18.16066 ? 438 HOH B O   1 
HETATM 4127 O  O   . HOH S 7 .   ? -7.33194  -13.56499 -34.93618 1.000 15.74064 ? 439 HOH B O   1 
HETATM 4128 O  O   . HOH S 7 .   ? -15.48926 -2.50291  -29.35427 1.000 14.42629 ? 440 HOH B O   1 
HETATM 4129 O  O   . HOH S 7 .   ? 18.23009  6.65408   -19.33119 1.000 33.13663 ? 441 HOH B O   1 
HETATM 4130 O  O   . HOH S 7 .   ? -14.05433 1.41335   -45.15025 1.000 31.06699 ? 442 HOH B O   1 
HETATM 4131 O  O   . HOH S 7 .   ? 18.57677  7.08983   -39.84287 1.000 17.66371 ? 443 HOH B O   1 
HETATM 4132 O  O   . HOH S 7 .   ? -17.64124 -16.02358 -25.90150 1.000 27.00767 ? 444 HOH B O   1 
HETATM 4133 O  O   . HOH S 7 .   ? 12.23262  -11.58794 -17.43324 1.000 21.25911 ? 445 HOH B O   1 
HETATM 4134 O  O   . HOH S 7 .   ? 20.00380  -11.60558 -30.71875 1.000 28.25836 ? 446 HOH B O   1 
HETATM 4135 O  O   . HOH S 7 .   ? 2.37244   -14.38258 -16.71937 1.000 37.14084 ? 447 HOH B O   1 
HETATM 4136 O  O   . HOH S 7 .   ? 8.55413   -1.55676  -15.12706 1.000 27.46006 ? 448 HOH B O   1 
HETATM 4137 O  O   . HOH S 7 .   ? -4.24739  -6.62490  -21.96834 1.000 9.29840  ? 449 HOH B O   1 
HETATM 4138 O  O   . HOH S 7 .   ? 4.05704   -17.45482 -18.08901 1.000 32.99742 ? 450 HOH B O   1 
HETATM 4139 O  O   . HOH S 7 .   ? 6.53770   12.80311  -34.73265 1.000 17.03270 ? 451 HOH B O   1 
HETATM 4140 O  O   . HOH S 7 .   ? -9.38345  -17.78191 -31.71475 1.000 33.80895 ? 452 HOH B O   1 
HETATM 4141 O  O   . HOH S 7 .   ? 9.74234   -19.98090 -25.65015 1.000 37.27645 ? 453 HOH B O   1 
HETATM 4142 O  O   . HOH S 7 .   ? 21.71557  -7.38697  -33.17616 1.000 28.13448 ? 454 HOH B O   1 
HETATM 4143 O  O   . HOH S 7 .   ? 13.91188  -8.21832  -31.61342 1.000 13.67991 ? 455 HOH B O   1 
HETATM 4144 O  O   . HOH S 7 .   ? 1.96203   -3.59502  -26.35866 1.000 21.81059 ? 456 HOH B O   1 
HETATM 4145 O  O   . HOH S 7 .   ? 19.65977  12.01558  -44.51417 1.000 29.68760 ? 457 HOH B O   1 
HETATM 4146 O  O   . HOH S 7 .   ? 1.13185   9.35091   -29.01286 1.000 16.76656 ? 458 HOH B O   1 
HETATM 4147 O  O   . HOH S 7 .   ? -5.49873  2.52562   -30.74029 1.000 13.57928 ? 459 HOH B O   1 
HETATM 4148 O  O   . HOH S 7 .   ? -9.84885  -10.61857 -19.29408 1.000 13.56658 ? 460 HOH B O   1 
HETATM 4149 O  O   . HOH S 7 .   ? 7.42652   2.86828   -25.10259 1.000 22.30031 ? 461 HOH B O   1 
HETATM 4150 O  O   . HOH S 7 .   ? 11.94123  7.83009   -32.55945 1.000 15.95447 ? 462 HOH B O   1 
HETATM 4151 O  O   . HOH S 7 .   ? 13.93855  -9.66621  -17.38684 1.000 24.69924 ? 463 HOH B O   1 
HETATM 4152 O  O   . HOH S 7 .   ? -16.34703 3.87447   -25.78718 1.000 38.39453 ? 464 HOH B O   1 
HETATM 4153 O  O   . HOH S 7 .   ? 4.15855   -13.36882 -24.61033 1.000 24.28194 ? 465 HOH B O   1 
HETATM 4154 O  O   . HOH S 7 .   ? 2.54152   -5.49367  -23.79912 1.000 15.56697 ? 466 HOH B O   1 
HETATM 4155 O  O   . HOH S 7 .   ? 1.66865   -11.63637 -44.87679 1.000 19.05047 ? 467 HOH B O   1 
HETATM 4156 O  O   . HOH S 7 .   ? 17.12200  -11.35531 -20.63768 1.000 27.61243 ? 468 HOH B O   1 
HETATM 4157 O  O   . HOH S 7 .   ? 6.24435   -13.71816 -26.48976 1.000 18.49302 ? 469 HOH B O   1 
HETATM 4158 O  O   . HOH S 7 .   ? -7.24568  0.28462   -21.35925 1.000 10.09951 ? 470 HOH B O   1 
HETATM 4159 O  O   . HOH S 7 .   ? -9.80932  1.41241   -31.00281 1.000 9.35229  ? 471 HOH B O   1 
HETATM 4160 O  O   . HOH S 7 .   ? 11.16353  -2.11515  -20.52729 1.000 10.43490 ? 472 HOH B O   1 
HETATM 4161 O  O   . HOH S 7 .   ? 2.02470   -16.77961 -33.60237 1.000 12.24968 ? 473 HOH B O   1 
HETATM 4162 O  O   . HOH S 7 .   ? 14.17685  -10.34160 -43.18299 1.000 26.49521 ? 474 HOH B O   1 
HETATM 4163 O  O   . HOH S 7 .   ? -17.44527 -1.01186  -31.53048 1.000 25.64320 ? 475 HOH B O   1 
HETATM 4164 O  O   . HOH S 7 .   ? 14.85191  15.26347  -43.49941 1.000 43.04994 ? 476 HOH B O   1 
HETATM 4165 O  O   . HOH S 7 .   ? 3.04403   -14.74274 -35.14951 1.000 9.90023  ? 477 HOH B O   1 
HETATM 4166 O  O   . HOH S 7 .   ? 4.63750   1.41107   -48.92082 1.000 27.66249 ? 478 HOH B O   1 
HETATM 4167 O  O   . HOH S 7 .   ? -13.09190 0.31377   -47.59444 1.000 25.25946 ? 479 HOH B O   1 
HETATM 4168 O  O   . HOH S 7 .   ? -3.45209  -5.51951  -26.75811 1.000 10.75121 ? 480 HOH B O   1 
HETATM 4169 O  O   . HOH S 7 .   ? 15.44608  -12.31382 -36.27168 1.000 22.64792 ? 481 HOH B O   1 
HETATM 4170 O  O   . HOH S 7 .   ? 20.16360  7.53289   -30.66917 1.000 32.97828 ? 482 HOH B O   1 
HETATM 4171 O  O   . HOH S 7 .   ? 12.92344  9.04384   -35.08633 1.000 15.78764 ? 483 HOH B O   1 
HETATM 4172 O  O   . HOH S 7 .   ? -3.57407  -15.70550 -18.35641 1.000 22.19230 ? 484 HOH B O   1 
HETATM 4173 O  O   . HOH S 7 .   ? 15.19934  -4.88244  -28.56920 1.000 13.31327 ? 485 HOH B O   1 
HETATM 4174 O  O   . HOH S 7 .   ? -14.89897 2.61982   -37.13263 1.000 18.38866 ? 486 HOH B O   1 
HETATM 4175 O  O   . HOH S 7 .   ? 12.30612  -11.39226 -33.81553 1.000 12.99455 ? 487 HOH B O   1 
HETATM 4176 O  O   . HOH S 7 .   ? -1.17234  -19.13007 -38.88366 1.000 14.48171 ? 488 HOH B O   1 
HETATM 4177 O  O   . HOH S 7 .   ? -7.06890  -18.64774 -42.14321 1.000 22.34471 ? 489 HOH B O   1 
HETATM 4178 O  O   . HOH S 7 .   ? 8.02058   7.30948   -15.25052 1.000 34.18889 ? 490 HOH B O   1 
HETATM 4179 O  O   . HOH S 7 .   ? 24.11040  -7.56652  -27.47086 1.000 32.76043 ? 491 HOH B O   1 
HETATM 4180 O  O   . HOH S 7 .   ? 12.87408  -1.19742  -28.28859 1.000 20.39973 ? 492 HOH B O   1 
HETATM 4181 O  O   . HOH S 7 .   ? 17.62337  -6.41874  -25.57583 1.000 17.01583 ? 493 HOH B O   1 
HETATM 4182 O  O   . HOH S 7 .   ? 12.52865  8.72405   -27.33693 1.000 31.25883 ? 494 HOH B O   1 
HETATM 4183 O  O   . HOH S 7 .   ? -8.59974  -8.81477  -40.60442 1.000 27.33616 ? 495 HOH B O   1 
HETATM 4184 O  O   . HOH S 7 .   ? -3.19527  17.55572  -17.99353 1.000 28.76284 ? 496 HOH B O   1 
HETATM 4185 O  O   . HOH S 7 .   ? -14.64806 -5.00421  -35.33058 1.000 12.65917 ? 497 HOH B O   1 
HETATM 4186 O  O   . HOH S 7 .   ? -2.85895  -2.69192  -26.35929 1.000 14.39188 ? 498 HOH B O   1 
HETATM 4187 O  O   . HOH S 7 .   ? -5.74796  14.91150  -38.67775 1.000 25.80922 ? 499 HOH B O   1 
HETATM 4188 O  O   . HOH S 7 .   ? 10.87000  10.44882  -29.76308 1.000 26.34352 ? 500 HOH B O   1 
HETATM 4189 O  O   . HOH S 7 .   ? 6.25524   0.87495   -24.19800 1.000 25.30163 ? 501 HOH B O   1 
HETATM 4190 O  O   . HOH S 7 .   ? -14.20550 9.74286   -25.49510 1.000 41.33991 ? 502 HOH B O   1 
HETATM 4191 O  O   . HOH S 7 .   ? -6.71425  7.26075   -19.04493 1.000 32.26319 ? 503 HOH B O   1 
HETATM 4192 O  O   . HOH S 7 .   ? -19.47266 -5.31534  -30.01776 1.000 19.83418 ? 504 HOH B O   1 
HETATM 4193 O  O   . HOH S 7 .   ? 4.36564   17.16358  -27.72486 1.000 38.61221 ? 505 HOH B O   1 
HETATM 4194 O  O   . HOH S 7 .   ? 19.52613  4.97058   -27.46870 1.000 24.48754 ? 506 HOH B O   1 
HETATM 4195 O  O   . HOH S 7 .   ? -18.31180 -0.23011  -26.64911 1.000 30.44856 ? 507 HOH B O   1 
HETATM 4196 O  O   . HOH S 7 .   ? 1.60336   -18.46870 -22.28269 1.000 21.87394 ? 508 HOH B O   1 
HETATM 4197 O  O   . HOH S 7 .   ? -6.90289  16.77202  -26.30411 1.000 13.85206 ? 509 HOH B O   1 
HETATM 4198 O  O   . HOH S 7 .   ? -0.92570  -10.57289 -19.66272 1.000 7.44507  ? 510 HOH B O   1 
HETATM 4199 O  O   . HOH S 7 .   ? -11.93600 18.10986  -30.85740 1.000 36.50550 ? 511 HOH B O   1 
HETATM 4200 O  O   . HOH S 7 .   ? -8.72319  -6.31141  -15.81353 1.000 16.64971 ? 512 HOH B O   1 
HETATM 4201 O  O   . HOH S 7 .   ? -14.70716 -5.24258  -39.57179 1.000 18.56053 ? 513 HOH B O   1 
HETATM 4202 O  O   . HOH S 7 .   ? -12.21086 15.72138  -33.49967 1.000 38.12071 ? 514 HOH B O   1 
HETATM 4203 O  O   . HOH S 7 .   ? 16.10287  -3.36146  -14.91720 1.000 29.61326 ? 515 HOH B O   1 
HETATM 4204 O  O   . HOH S 7 .   ? 13.75128  3.85026   -17.76638 1.000 15.48326 ? 516 HOH B O   1 
HETATM 4205 O  O   . HOH S 7 .   ? -14.19281 0.30462   -21.92077 1.000 18.02255 ? 517 HOH B O   1 
HETATM 4206 O  O   . HOH S 7 .   ? -11.43163 13.63322  -19.68632 1.000 36.02695 ? 518 HOH B O   1 
HETATM 4207 O  O   . HOH S 7 .   ? -15.31901 2.49849   -24.22538 1.000 28.79705 ? 519 HOH B O   1 
HETATM 4208 O  O   . HOH S 7 .   ? 4.98622   16.90570  -33.86022 1.000 27.71338 ? 520 HOH B O   1 
HETATM 4209 O  O   . HOH S 7 .   ? 4.17870   9.24674   -22.12602 1.000 24.06230 ? 521 HOH B O   1 
HETATM 4210 O  O   . HOH S 7 .   ? -5.70211  -14.31984 -41.75277 1.000 13.58556 ? 522 HOH B O   1 
HETATM 4211 O  O   . HOH S 7 .   ? 14.22033  -12.06833 -26.45563 1.000 21.22952 ? 523 HOH B O   1 
HETATM 4212 O  O   . HOH S 7 .   ? 17.73809  -3.93285  -28.13185 1.000 13.60062 ? 524 HOH B O   1 
HETATM 4213 O  O   . HOH S 7 .   ? -5.42158  -12.91836 -14.70162 1.000 24.41170 ? 525 HOH B O   1 
HETATM 4214 O  O   . HOH S 7 .   ? -15.40384 -6.44344  -12.39574 1.000 16.14728 ? 526 HOH B O   1 
HETATM 4215 O  O   . HOH S 7 .   ? 12.19839  -10.32331 -27.12167 1.000 17.10883 ? 527 HOH B O   1 
HETATM 4216 O  O   . HOH S 7 .   ? 0.55198   -3.61752  -48.87561 1.000 28.15764 ? 528 HOH B O   1 
HETATM 4217 O  O   . HOH S 7 .   ? 15.48364  9.51983   -24.76648 1.000 35.27243 ? 529 HOH B O   1 
HETATM 4218 O  O   . HOH S 7 .   ? -12.86375 7.74796   -19.41915 1.000 44.26585 ? 530 HOH B O   1 
HETATM 4219 O  O   . HOH S 7 .   ? -11.15499 -1.51336  -30.78543 1.000 12.06022 ? 531 HOH B O   1 
HETATM 4220 O  O   . HOH S 7 .   ? -5.46987  -21.26000 -34.71512 1.000 31.54813 ? 532 HOH B O   1 
HETATM 4221 O  O   . HOH S 7 .   ? 4.12142   -15.73939 -43.29320 1.000 38.73836 ? 533 HOH B O   1 
HETATM 4222 O  O   . HOH S 7 .   ? 0.08451   -1.14767  -23.74660 1.000 20.21562 ? 534 HOH B O   1 
HETATM 4223 O  O   . HOH S 7 .   ? -1.37501  12.44278  -47.36671 1.000 45.79202 ? 535 HOH B O   1 
HETATM 4224 O  O   . HOH S 7 .   ? 20.61994  10.56004  -40.16859 1.000 36.19984 ? 536 HOH B O   1 
HETATM 4225 O  O   . HOH S 7 .   ? -13.38224 -1.96735  -40.82621 1.000 20.65920 ? 537 HOH B O   1 
HETATM 4226 O  O   . HOH S 7 .   ? -3.02041  -15.86214 -27.61315 1.000 20.36705 ? 538 HOH B O   1 
HETATM 4227 O  O   . HOH S 7 .   ? 21.97770  4.10956   -34.89082 1.000 21.31689 ? 539 HOH B O   1 
HETATM 4228 O  O   . HOH S 7 .   ? -3.44153  8.93329   -17.88034 1.000 23.28645 ? 540 HOH B O   1 
HETATM 4229 O  O   . HOH S 7 .   ? 6.03928   -9.67879  -39.24635 1.000 13.97038 ? 541 HOH B O   1 
HETATM 4230 O  O   . HOH S 7 .   ? 16.89831  -13.14038 -23.88425 1.000 28.73223 ? 542 HOH B O   1 
HETATM 4231 O  O   . HOH S 7 .   ? 13.70707  -9.02015  -34.24466 1.000 9.88507  ? 543 HOH B O   1 
HETATM 4232 O  O   . HOH S 7 .   ? 8.49180   -17.09403 -34.14775 1.000 32.00683 ? 544 HOH B O   1 
HETATM 4233 O  O   . HOH S 7 .   ? -10.49998 -3.15143  -44.34543 1.000 33.93352 ? 545 HOH B O   1 
HETATM 4234 O  O   . HOH S 7 .   ? -6.65336  -14.06546 -20.35095 1.000 16.51570 ? 546 HOH B O   1 
HETATM 4235 O  O   . HOH S 7 .   ? 1.47262   8.29820   -18.71937 1.000 31.04513 ? 547 HOH B O   1 
HETATM 4236 O  O   . HOH S 7 .   ? -9.43066  -3.32916  -16.11739 1.000 28.56298 ? 548 HOH B O   1 
HETATM 4237 O  O   . HOH S 7 .   ? -7.794    -16.121   -34.668   1.000 41.39542 ? 549 HOH B O   1 
HETATM 4238 O  O   . HOH S 7 .   ? -6.17194  4.53111   -20.24926 1.000 28.97808 ? 550 HOH B O   1 
HETATM 4239 O  O   . HOH S 7 .   ? 2.40585   -14.20306 -43.34307 1.000 21.88929 ? 551 HOH B O   1 
HETATM 4240 O  O   . HOH S 7 .   ? -15.29376 -7.47597  -19.62882 1.000 11.91636 ? 552 HOH B O   1 
HETATM 4241 O  O   . HOH S 7 .   ? 8.50386   -10.51871 -42.08516 1.000 29.44855 ? 553 HOH B O   1 
HETATM 4242 O  O   . HOH S 7 .   ? 7.00414   9.98122   -28.68853 1.000 15.94681 ? 554 HOH B O   1 
HETATM 4243 O  O   . HOH S 7 .   ? -6.25783  -6.42154  -15.49464 1.000 19.69182 ? 555 HOH B O   1 
HETATM 4244 O  O   . HOH S 7 .   ? 12.79896  12.76018  -48.24353 1.000 40.58954 ? 556 HOH B O   1 
HETATM 4245 O  O   . HOH S 7 .   ? 4.28038   -2.62633  -13.18392 1.000 23.91970 ? 557 HOH B O   1 
HETATM 4246 O  O   . HOH S 7 .   ? -13.22695 -1.19561  -17.56558 1.000 32.25171 ? 558 HOH B O   1 
HETATM 4247 O  O   . HOH S 7 .   ? 8.76275   -14.24136 -17.31011 1.000 37.91983 ? 559 HOH B O   1 
HETATM 4248 O  O   . HOH S 7 .   ? 16.85075  -12.71495 -27.55973 1.000 26.49923 ? 560 HOH B O   1 
HETATM 4249 O  O   . HOH S 7 .   ? -16.61370 5.02367   -30.37384 1.000 24.62804 ? 561 HOH B O   1 
HETATM 4250 O  O   . HOH S 7 .   ? 14.13125  -2.78832  -27.21503 1.000 20.21052 ? 562 HOH B O   1 
HETATM 4251 O  O   . HOH S 7 .   ? 19.84503  4.64301   -30.29054 1.000 26.88794 ? 563 HOH B O   1 
HETATM 4252 O  O   . HOH S 7 .   ? -1.50838  -18.77702 -25.67306 1.000 31.38542 ? 564 HOH B O   1 
HETATM 4253 O  O   . HOH S 7 .   ? -5.89567  -5.67818  -28.21842 1.000 8.39548  ? 565 HOH B O   1 
HETATM 4254 O  O   . HOH S 7 .   ? 10.95287  11.22585  -48.61294 1.000 34.92003 ? 566 HOH B O   1 
HETATM 4255 O  O   . HOH S 7 .   ? 7.12373   -16.50491 -23.70752 1.000 28.36778 ? 567 HOH B O   1 
HETATM 4256 O  O   . HOH S 7 .   ? 10.96663  -6.19766  -47.94820 1.000 26.49772 ? 568 HOH B O   1 
HETATM 4257 O  O   . HOH S 7 .   ? 6.43152   14.37170  -27.08219 1.000 32.72830 ? 569 HOH B O   1 
HETATM 4258 O  O   . HOH S 7 .   ? 9.19209   -16.46078 -39.25353 1.000 34.70571 ? 570 HOH B O   1 
HETATM 4259 O  O   . HOH S 7 .   ? 11.60763  14.73440  -37.32049 1.000 33.32524 ? 571 HOH B O   1 
HETATM 4260 O  O   . HOH S 7 .   ? 17.44021  -13.90441 -34.22651 1.000 24.27296 ? 572 HOH B O   1 
HETATM 4261 O  O   . HOH S 7 .   ? -9.94447  -12.63508 -13.59471 1.000 18.92251 ? 573 HOH B O   1 
HETATM 4262 O  O   . HOH S 7 .   ? -3.46229  -5.27441  -16.21489 1.000 14.63443 ? 574 HOH B O   1 
HETATM 4263 O  O   . HOH S 7 .   ? 8.94226   11.37528  -42.24063 1.000 22.27242 ? 575 HOH B O   1 
HETATM 4264 O  O   . HOH S 7 .   ? -8.62834  10.01850  -40.68554 1.000 22.04212 ? 576 HOH B O   1 
HETATM 4265 O  O   . HOH S 7 .   ? -13.81174 15.12548  -25.27487 1.000 41.62510 ? 577 HOH B O   1 
HETATM 4266 O  O   . HOH S 7 .   ? 23.45616  -2.97873  -23.04969 1.000 27.36498 ? 578 HOH B O   1 
HETATM 4267 O  O   . HOH S 7 .   ? 20.96381  8.04061   -45.96571 1.000 17.47573 ? 579 HOH B O   1 
HETATM 4268 O  O   . HOH S 7 .   ? 9.36268   -15.53321 -23.49223 1.000 27.42473 ? 580 HOH B O   1 
HETATM 4269 O  O   . HOH S 7 .   ? 18.46878  -9.04539  -25.89161 1.000 26.54696 ? 581 HOH B O   1 
HETATM 4270 O  O   . HOH S 7 .   ? 6.41828   -0.86033  -49.45626 1.000 40.59316 ? 582 HOH B O   1 
HETATM 4271 O  O   . HOH S 7 .   ? 16.02833  -3.06422  -44.69797 1.000 23.34046 ? 583 HOH B O   1 
HETATM 4272 O  O   . HOH S 7 .   ? 11.24282  1.82894   -33.28795 1.000 14.50742 ? 584 HOH B O   1 
HETATM 4273 O  O   . HOH S 7 .   ? 6.30583   -12.74102 -21.76903 1.000 18.78488 ? 585 HOH B O   1 
HETATM 4274 O  O   . HOH S 7 .   ? 7.10636   -14.97871 -41.93082 1.000 30.95371 ? 586 HOH B O   1 
HETATM 4275 O  O   . HOH S 7 .   ? 25.04666  -2.65071  -20.44220 1.000 43.27188 ? 587 HOH B O   1 
HETATM 4276 O  O   . HOH S 7 .   ? -16.327   -5.112    -31.638   1.000 29.80695 ? 588 HOH B O   1 
HETATM 4277 O  O   . HOH S 7 .   ? 11.65492  -12.48068 -41.58128 1.000 39.78327 ? 589 HOH B O   1 
HETATM 4278 O  O   . HOH S 7 .   ? 14.98185  13.93029  -32.31272 1.000 46.60276 ? 590 HOH B O   1 
HETATM 4279 O  O   . HOH S 7 .   ? 0.74376   -8.30193  -43.47381 1.000 22.56496 ? 591 HOH B O   1 
HETATM 4280 O  O   . HOH S 7 .   ? 9.66419   15.56133  -34.60336 1.000 25.98978 ? 592 HOH B O   1 
HETATM 4281 O  O   . HOH S 7 .   ? -6.41045  16.35071  -42.59308 1.000 34.85166 ? 593 HOH B O   1 
HETATM 4282 O  O   . HOH S 7 .   ? -11.45096 2.04145   -19.66521 1.000 15.21960 ? 594 HOH B O   1 
HETATM 4283 O  O   . HOH S 7 .   ? 13.09645  6.50999   -18.14144 1.000 16.37208 ? 595 HOH B O   1 
HETATM 4284 O  O   . HOH S 7 .   ? -1.74899  4.67969   -14.99651 1.000 45.77966 ? 596 HOH B O   1 
HETATM 4285 O  O   . HOH S 7 .   ? 13.78192  7.63581   -30.85224 1.000 35.63172 ? 597 HOH B O   1 
HETATM 4286 O  O   . HOH S 7 .   ? -7.85701  3.95123   -46.51812 1.000 24.95300 ? 598 HOH B O   1 
HETATM 4287 O  O   . HOH S 7 .   ? -11.432   21.040    -19.231   1.000 34.26683 ? 599 HOH B O   1 
HETATM 4288 O  O   . HOH S 7 .   ? 7.83067   14.10488  -37.07694 1.000 26.60051 ? 600 HOH B O   1 
HETATM 4289 O  O   . HOH S 7 .   ? -12.69957 -3.95483  -28.06947 1.000 19.58006 ? 601 HOH B O   1 
HETATM 4290 O  O   . HOH S 7 .   ? -13.69111 13.09082  -28.09136 1.000 27.75115 ? 602 HOH B O   1 
HETATM 4291 O  O   . HOH S 7 .   ? 13.31863  -14.91984 -26.44946 1.000 28.83099 ? 603 HOH B O   1 
HETATM 4292 O  O   . HOH S 7 .   ? 4.61676   4.02480   -23.71141 1.000 29.03562 ? 604 HOH B O   1 
HETATM 4293 O  O   . HOH S 7 .   ? 3.54285   8.31055   -19.86066 1.000 29.18367 ? 605 HOH B O   1 
HETATM 4294 O  O   . HOH S 7 .   ? -7.98759  -6.47022  -43.01481 1.000 27.79874 ? 606 HOH B O   1 
HETATM 4295 O  O   . HOH S 7 .   ? 21.61523  -9.25154  -30.82310 1.000 28.97206 ? 607 HOH B O   1 
HETATM 4296 O  O   . HOH S 7 .   ? -14.32639 12.25228  -32.00620 1.000 24.78723 ? 608 HOH B O   1 
HETATM 4297 O  O   . HOH S 7 .   ? -19.94139 -16.06219 -25.28473 1.000 41.67683 ? 609 HOH B O   1 
HETATM 4298 O  O   . HOH S 7 .   ? 6.42649   -7.12897  -48.16242 1.000 31.73430 ? 610 HOH B O   1 
HETATM 4299 O  O   . HOH S 7 .   ? -0.80267  -9.88389  -45.43822 1.000 14.89318 ? 611 HOH B O   1 
HETATM 4300 O  O   . HOH S 7 .   ? -13.385   4.863     -35.233   1.000 26.04949 ? 612 HOH B O   1 
HETATM 4301 O  O   . HOH S 7 .   ? 8.74126   -13.32074 -41.86888 1.000 33.61970 ? 613 HOH B O   1 
HETATM 4302 O  O   . HOH S 7 .   ? -16.06469 -7.08678  -34.04765 1.000 17.99458 ? 614 HOH B O   1 
HETATM 4303 O  O   . HOH S 7 .   ? -0.25947  -1.87513  -26.17208 1.000 19.15431 ? 615 HOH B O   1 
HETATM 4304 O  O   . HOH S 7 .   ? 8.10668   6.11774   -58.36978 1.000 56.47541 ? 616 HOH B O   1 
HETATM 4305 O  O   . HOH S 7 .   ? -11.59379 -9.89122  -39.02684 1.000 29.87325 ? 617 HOH B O   1 
HETATM 4306 O  O   . HOH S 7 .   ? 6.42619   8.09558   -57.48776 1.000 53.00910 ? 618 HOH B O   1 
HETATM 4307 O  O   . HOH S 7 .   ? -5.07588  1.71421   -49.13524 1.000 62.85512 ? 619 HOH B O   1 
HETATM 4308 O  O   . HOH S 7 .   ? -13.83521 -15.73483 -28.03239 1.000 36.00123 ? 620 HOH B O   1 
HETATM 4309 O  O   . HOH S 7 .   ? 1.799     18.368    -43.908   1.000 46.47793 ? 621 HOH B O   1 
HETATM 4310 O  O   . HOH S 7 .   ? -10.362   18.788    -25.868   1.000 32.37493 ? 622 HOH B O   1 
HETATM 4311 O  O   . HOH S 7 .   ? -2.38210  -11.40519 -48.73220 1.000 36.94649 ? 623 HOH B O   1 
HETATM 4312 O  O   . HOH S 7 .   ? -3.45967  -22.36647 -34.16906 1.000 35.47494 ? 624 HOH B O   1 
HETATM 4313 O  O   . HOH S 7 .   ? -12.957   5.665     -37.933   1.000 25.82618 ? 625 HOH B O   1 
HETATM 4314 O  O   . HOH S 7 .   ? 5.48999   -0.39915  -11.93593 1.000 26.54395 ? 626 HOH B O   1 
HETATM 4315 O  O   . HOH S 7 .   ? -15.311   4.558     -39.212   1.000 28.44826 ? 627 HOH B O   1 
HETATM 4316 O  O   . HOH S 7 .   ? -11.90862 6.33360   -18.83486 1.000 44.20621 ? 628 HOH B O   1 
HETATM 4317 O  O   . HOH S 7 .   ? -7.173    22.539    -40.406   1.000 30.29124 ? 629 HOH B O   1 
HETATM 4318 O  O   . HOH S 7 .   ? 3.03521   19.05764  -29.29380 1.000 45.60344 ? 630 HOH B O   1 
HETATM 4319 O  O   . HOH S 7 .   ? 6.13853   11.12877  -22.12482 1.000 27.78237 ? 631 HOH B O   1 
HETATM 4320 O  O   . HOH S 7 .   ? 20.14009  11.98175  -38.17766 1.000 51.86862 ? 632 HOH B O   1 
HETATM 4321 O  O   . HOH S 7 .   ? 21.41987  6.24297   -39.71350 1.000 21.34877 ? 633 HOH B O   1 
HETATM 4322 O  O   . HOH S 7 .   ? -0.385    -23.294   -38.572   1.000 32.71083 ? 634 HOH B O   1 
HETATM 4323 O  O   . HOH S 7 .   ? -16.73892 -6.30097  -17.48777 1.000 24.17186 ? 635 HOH B O   1 
HETATM 4324 O  O   . HOH S 7 .   ? -18.03183 3.93286   -31.89461 1.000 49.32689 ? 636 HOH B O   1 
HETATM 4325 O  O   . HOH S 7 .   ? -1.90727  6.75331   -15.35342 1.000 39.18269 ? 637 HOH B O   1 
HETATM 4326 O  O   . HOH S 7 .   ? 20.33858  7.31982   -26.09711 1.000 41.94680 ? 638 HOH B O   1 
HETATM 4327 O  O   . HOH S 7 .   ? 4.46508   -5.41850  -49.19601 1.000 44.23529 ? 639 HOH B O   1 
HETATM 4328 O  O   . HOH S 7 .   ? 22.95862  -4.90579  -31.87569 1.000 36.62175 ? 640 HOH B O   1 
HETATM 4329 O  O   . HOH S 7 .   ? -12.50349 -12.43770 -39.21908 1.000 43.34302 ? 641 HOH B O   1 
HETATM 4330 O  O   . HOH S 7 .   ? 12.53434  7.66854   -15.09805 1.000 37.90095 ? 642 HOH B O   1 
HETATM 4331 O  O   . HOH S 7 .   ? -16.14781 7.25343   -29.61058 1.000 28.92163 ? 643 HOH B O   1 
HETATM 4332 O  O   . HOH S 7 .   ? 6.24396   15.25998  -25.41614 1.000 45.61751 ? 644 HOH B O   1 
HETATM 4333 O  O   . HOH S 7 .   ? 11.06940  15.11967  -42.45954 1.000 40.90531 ? 645 HOH B O   1 
HETATM 4334 O  O   . HOH S 7 .   ? 13.42047  -13.39349 -35.00261 1.000 22.74201 ? 646 HOH B O   1 
HETATM 4335 O  O   . HOH S 7 .   ? 22.86227  5.36762   -20.86325 1.000 36.79009 ? 647 HOH B O   1 
HETATM 4336 O  O   . HOH S 7 .   ? 20.18220  -5.20606  -41.08913 1.000 32.59019 ? 648 HOH B O   1 
HETATM 4337 O  O   . HOH S 7 .   ? 12.69781  -15.57946 -35.92141 1.000 33.70256 ? 649 HOH B O   1 
HETATM 4338 O  O   . HOH S 7 .   ? -1.03550  -12.52756 -13.52767 1.000 25.65685 ? 650 HOH B O   1 
HETATM 4339 O  O   . HOH S 7 .   ? -0.97241  -2.67950  -15.19151 1.000 20.10422 ? 651 HOH B O   1 
HETATM 4340 O  O   . HOH S 7 .   ? 18.38661  -9.47406  -16.83100 1.000 37.15636 ? 652 HOH B O   1 
HETATM 4341 O  O   . HOH S 7 .   ? 5.43101   15.00346  -37.44262 1.000 45.20410 ? 653 HOH B O   1 
HETATM 4342 O  O   . HOH S 7 .   ? -19.66749 -12.04384 -14.55337 1.000 37.14684 ? 654 HOH B O   1 
HETATM 4343 O  O   . HOH S 7 .   ? 21.91708  9.83920   -31.10328 1.000 45.68675 ? 655 HOH B O   1 
HETATM 4344 O  O   . HOH S 7 .   ? -4.30761  -11.91996 -49.65099 1.000 40.93099 ? 656 HOH B O   1 
HETATM 4345 O  O   . HOH S 7 .   ? -25.824   -9.607    -21.287   1.000 40.02998 ? 657 HOH B O   1 
HETATM 4346 O  O   . HOH S 7 .   ? 13.03863  -16.43667 -28.80489 1.000 33.71017 ? 658 HOH B O   1 
HETATM 4347 O  O   . HOH S 7 .   ? -1.03987  16.40760  -18.51043 1.000 32.72540 ? 659 HOH B O   1 
HETATM 4348 O  O   . HOH S 7 .   ? -9.46108  9.96752   -43.60367 1.000 41.41991 ? 660 HOH B O   1 
HETATM 4349 O  O   . HOH S 7 .   ? -13.55883 11.50422  -22.48185 1.000 43.67569 ? 661 HOH B O   1 
HETATM 4350 O  O   . HOH S 7 .   ? 17.04686  -15.11136 -28.84154 1.000 37.68179 ? 662 HOH B O   1 
HETATM 4351 O  O   . HOH S 7 .   ? 13.36769  -13.86522 -18.21937 1.000 37.23869 ? 663 HOH B O   1 
HETATM 4352 O  O   . HOH S 7 .   ? 12.98155  -15.51009 -38.97811 1.000 38.42237 ? 664 HOH B O   1 
HETATM 4353 O  O   . HOH S 7 .   ? -15.163   4.015     -42.047   1.000 22.94659 ? 665 HOH B O   1 
HETATM 4354 O  O   . HOH S 7 .   ? -14.39133 7.56792   -24.92702 1.000 29.93904 ? 666 HOH B O   1 
HETATM 4355 O  O   . HOH S 7 .   ? -14.966   3.548     -44.390   1.000 29.74502 ? 667 HOH B O   1 
HETATM 4356 O  O   . HOH S 7 .   ? 10.31805  14.26354  -44.91192 1.000 39.38900 ? 668 HOH B O   1 
HETATM 4357 O  O   . HOH S 7 .   ? -6.64927  -16.83905 -20.91367 1.000 27.20400 ? 669 HOH B O   1 
HETATM 4358 O  O   . HOH S 7 .   ? 10.22921  3.93643   -9.17721  1.000 32.89107 ? 670 HOH B O   1 
HETATM 4359 O  O   . HOH S 7 .   ? 11.53033  -10.26747 -43.05979 1.000 43.57945 ? 671 HOH B O   1 
HETATM 4360 O  O   . HOH S 7 .   ? 0.582     15.913    -49.147   1.000 40.81404 ? 672 HOH B O   1 
HETATM 4361 O  O   . HOH S 7 .   ? -26.879   -12.799   -22.264   1.000 49.02619 ? 673 HOH B O   1 
HETATM 4362 O  O   . HOH S 7 .   ? -16.32037 1.04437   -23.16649 1.000 29.89888 ? 674 HOH B O   1 
HETATM 4363 O  O   . HOH S 7 .   ? 18.45686  -12.43255 -26.18598 1.000 41.46277 ? 675 HOH B O   1 
HETATM 4364 O  O   . HOH S 7 .   ? 11.51722  -19.50479 -26.99249 1.000 33.40952 ? 676 HOH B O   1 
HETATM 4365 O  O   . HOH S 7 .   ? 4.75825   -18.05544 -21.71826 1.000 30.92518 ? 677 HOH B O   1 
HETATM 4366 O  O   . HOH S 7 .   ? 4.623     18.181    -38.525   1.000 48.90777 ? 678 HOH B O   1 
HETATM 4367 O  O   . HOH S 7 .   ? 11.94509  -16.53343 -25.10041 1.000 33.25812 ? 679 HOH B O   1 
HETATM 4368 O  O   . HOH S 7 .   ? 8.43946   11.06835  -49.53339 1.000 46.66203 ? 680 HOH B O   1 
HETATM 4369 O  O   . HOH S 7 .   ? -19.06544 -2.48134  -30.30933 1.000 32.57493 ? 681 HOH B O   1 
HETATM 4370 O  O   . HOH S 7 .   ? -7.81959  19.37113  -27.00820 1.000 24.53656 ? 682 HOH B O   1 
HETATM 4371 O  O   . HOH S 7 .   ? 9.39826   13.80361  -43.24763 1.000 44.76883 ? 683 HOH B O   1 
HETATM 4372 O  O   . HOH S 7 .   ? -16.10904 -11.02677 -11.13512 1.000 29.19975 ? 684 HOH B O   1 
HETATM 4373 O  O   . HOH S 7 .   ? -7.71602  6.24086   -46.58988 1.000 50.99522 ? 685 HOH B O   1 
HETATM 4374 O  O   . HOH S 7 .   ? -3.75778  -15.31579 -15.44905 1.000 39.07836 ? 686 HOH B O   1 
HETATM 4375 O  O   . HOH S 7 .   ? -18.44091 -10.26085 -12.05436 1.000 35.88284 ? 687 HOH B O   1 
HETATM 4376 O  O   . HOH S 7 .   ? 18.91502  8.32398   -21.33949 1.000 37.22357 ? 688 HOH B O   1 
HETATM 4377 O  O   . HOH S 7 .   ? -9.61449  -12.72088 -18.45684 1.000 28.22614 ? 689 HOH B O   1 
HETATM 4378 O  O   . HOH S 7 .   ? 21.74111  9.68525   -27.28057 1.000 39.30186 ? 690 HOH B O   1 
HETATM 4379 O  O   . HOH S 7 .   ? 22.15749  -5.88130  -36.31195 1.000 33.26492 ? 691 HOH B O   1 
HETATM 4380 O  O   . HOH S 7 .   ? -4.07044  6.65795   -15.79853 1.000 31.64557 ? 692 HOH B O   1 
HETATM 4381 O  O   . HOH S 7 .   ? -21.16314 -10.88081 -16.40766 1.000 46.08035 ? 693 HOH B O   1 
HETATM 4382 O  O   . HOH S 7 .   ? 7.99078   11.92648  -27.04450 1.000 26.60847 ? 694 HOH B O   1 
HETATM 4383 O  O   . HOH S 7 .   ? 20.92099  -13.65402 -31.97844 1.000 47.46424 ? 695 HOH B O   1 
HETATM 4384 O  O   . HOH S 7 .   ? 7.42415   12.47047  -24.51849 1.000 34.17312 ? 696 HOH B O   1 
HETATM 4385 O  O   . HOH S 7 .   ? 0.08567   -15.20739 -16.86047 1.000 35.90264 ? 697 HOH B O   1 
HETATM 4386 O  O   . HOH S 7 .   ? -15.731   5.511     -40.765   1.000 32.63398 ? 698 HOH B O   1 
HETATM 4387 O  O   . HOH S 7 .   ? -11.03613 9.69883   -39.64900 1.000 31.38850 ? 699 HOH B O   1 
HETATM 4388 O  O   . HOH S 7 .   ? 16.47702  -14.08124 -20.89757 1.000 36.84139 ? 700 HOH B O   1 
HETATM 4389 O  O   . HOH S 7 .   ? -9.01952  -10.77805 -42.21149 1.000 30.39891 ? 701 HOH B O   1 
HETATM 4390 O  O   . HOH S 7 .   ? -27.398   -10.877   -21.189   1.000 32.44381 ? 702 HOH B O   1 
HETATM 4391 O  O   . HOH S 7 .   ? 10.93618  -16.17984 -17.82616 1.000 47.75452 ? 703 HOH B O   1 
HETATM 4392 O  O   . HOH S 7 .   ? -11.14665 -13.79508 -15.62300 1.000 29.94852 ? 704 HOH B O   1 
HETATM 4393 O  O   . HOH S 7 .   ? -12.57290 7.60884   -38.44471 1.000 34.95697 ? 705 HOH B O   1 
HETATM 4394 O  O   . HOH S 7 .   ? -17.98237 6.36259   -26.85760 1.000 36.60868 ? 706 HOH B O   1 
HETATM 4395 O  O   . HOH S 7 .   ? -8.50034  -13.72146 -42.35777 1.000 33.25741 ? 707 HOH B O   1 
HETATM 4396 O  O   . HOH S 7 .   ? 14.46114  -15.73000 -33.73712 1.000 35.74199 ? 708 HOH B O   1 
HETATM 4397 O  O   . HOH S 7 .   ? -14.69722 12.75307  -23.95955 1.000 43.89773 ? 709 HOH B O   1 
HETATM 4398 O  O   . HOH S 7 .   ? -15.72550 -12.99122 -10.81281 1.000 53.21746 ? 710 HOH B O   1 
HETATM 4399 O  O   . HOH S 7 .   ? 5.11560   -0.84480  -57.87563 1.000 41.22050 ? 711 HOH B O   1 
HETATM 4400 O  O   . HOH S 7 .   ? -5.83361  3.34369   -50.23496 1.000 54.45163 ? 712 HOH B O   1 
HETATM 4401 O  O   . HOH S 7 .   ? 3.02385   -7.78833  -50.90047 1.000 38.38766 ? 713 HOH B O   1 
HETATM 4402 O  O   . HOH S 7 .   ? -17.79901 9.05649   -25.17611 1.000 53.91005 ? 714 HOH B O   1 
HETATM 4403 O  O   . HOH S 7 .   ? 4.91489   -1.62096  -55.34148 1.000 61.36305 ? 715 HOH B O   1 
HETATM 4404 O  O   . HOH S 7 .   ? 20.85213  -13.11202 -25.01063 1.000 54.64411 ? 716 HOH B O   1 
HETATM 4405 O  O   . HOH S 7 .   ? 14.01551  -17.87704 -33.08268 1.000 46.55173 ? 717 HOH B O   1 
HETATM 4406 O  O   . HOH S 7 .   ? 11.87728  -8.73774  -50.79930 1.000 43.65604 ? 718 HOH B O   1 
HETATM 4407 O  O   . HOH S 7 .   ? -17.87022 8.63564   -23.12005 1.000 42.37509 ? 719 HOH B O   1 
HETATM 4408 O  O   . HOH S 7 .   ? 15.06942  -10.51148 -50.51662 1.000 46.03784 ? 720 HOH B O   1 
HETATM 4409 O  O   . HOH S 7 .   ? 14.21999  -9.25175  -52.53940 1.000 50.39646 ? 721 HOH B O   1 
HETATM 4410 O  O   . HOH S 7 .   ? 3.99346   -7.03388  -52.81672 1.000 45.39804 ? 722 HOH B O   1 
# 
