data_9DQ0
# 
_entry.id   9DQ0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DQ0         pdb_00009dq0 10.2210/pdb9dq0/pdb 
WWPDB D_1000288584 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DQ0 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wchang6@ncsu.edu 
_pdbx_contact_author.name_first         Wei-chen 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2341-9846 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, Y.-C.' 1 ? 
'Chang, W.-C.' 2 ? 
'Swartz, P.'   3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Am.Chem.Soc. 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            147 
_citation.language                  ? 
_citation.page_first                6162 
_citation.page_last                 6170 
_citation.title                     
;Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.4c17741 
_citation.pdbx_database_id_PubMed   39901767 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, Y.C.'   1  ? 
primary 'Li, X.'        2  ? 
primary 'Cha, L.'       3  ? 
primary 'Paris, J.C.'   4  ? 
primary 'Michael, C.'   5  ? 
primary 'Ushimaru, R.'  6  ? 
primary 'Ogasawara, Y.' 7  ? 
primary 'Abe, I.'       8  ? 
primary 'Guo, Y.'       9  ? 
primary 'Chang, W.C.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'BsmA domain containing protein' 26498.471 2   ? ? ? ? 
2 non-polymer syn 'ACETIC ACID'                    60.052    6   ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                  24.305    8   ? ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                   62.068    1   ? ? ? ? 
5 water       nat water                            18.015    501 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEAHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEAHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ACETIC ACID'   ACY 
3 'MAGNESIUM ION' MG  
4 1,2-ETHANEDIOL  EDO 
5 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   PRO n 
1 3   LEU n 
1 4   GLY n 
1 5   THR n 
1 6   GLU n 
1 7   GLY n 
1 8   PHE n 
1 9   THR n 
1 10  VAL n 
1 11  ILE n 
1 12  ASP n 
1 13  LEU n 
1 14  PRO n 
1 15  GLU n 
1 16  VAL n 
1 17  ALA n 
1 18  PRO n 
1 19  ASP n 
1 20  ILE n 
1 21  LEU n 
1 22  PRO n 
1 23  SER n 
1 24  TYR n 
1 25  ASP n 
1 26  ARG n 
1 27  CYS n 
1 28  PRO n 
1 29  VAL n 
1 30  ASP n 
1 31  ASP n 
1 32  TYR n 
1 33  MET n 
1 34  GLY n 
1 35  ASN n 
1 36  GLY n 
1 37  THR n 
1 38  ARG n 
1 39  PHE n 
1 40  LYS n 
1 41  ARG n 
1 42  PHE n 
1 43  SER n 
1 44  GLN n 
1 45  TYR n 
1 46  LYS n 
1 47  LEU n 
1 48  THR n 
1 49  PRO n 
1 50  ALA n 
1 51  GLU n 
1 52  ASP n 
1 53  ASP n 
1 54  THR n 
1 55  TRP n 
1 56  SER n 
1 57  PHE n 
1 58  LYS n 
1 59  ARG n 
1 60  LEU n 
1 61  PRO n 
1 62  HIS n 
1 63  ARG n 
1 64  ASP n 
1 65  TYR n 
1 66  THR n 
1 67  THR n 
1 68  TYR n 
1 69  LYS n 
1 70  LYS n 
1 71  PHE n 
1 72  ASN n 
1 73  PRO n 
1 74  VAL n 
1 75  GLY n 
1 76  GLY n 
1 77  GLY n 
1 78  ILE n 
1 79  ARG n 
1 80  ARG n 
1 81  VAL n 
1 82  TYR n 
1 83  GLU n 
1 84  PRO n 
1 85  ILE n 
1 86  GLU n 
1 87  VAL n 
1 88  ASP n 
1 89  PHE n 
1 90  THR n 
1 91  PRO n 
1 92  LEU n 
1 93  ILE n 
1 94  SER n 
1 95  GLU n 
1 96  GLY n 
1 97  ILE n 
1 98  ARG n 
1 99  GLU n 
1 100 LEU n 
1 101 GLY n 
1 102 LEU n 
1 103 ASP n 
1 104 ARG n 
1 105 SER n 
1 106 GLU n 
1 107 PRO n 
1 108 TRP n 
1 109 GLN n 
1 110 ILE n 
1 111 ASN n 
1 112 VAL n 
1 113 HIS n 
1 114 GLN n 
1 115 ASN n 
1 116 ARG n 
1 117 THR n 
1 118 ARG n 
1 119 ALA n 
1 120 ASP n 
1 121 GLY n 
1 122 GLY n 
1 123 ARG n 
1 124 PRO n 
1 125 GLY n 
1 126 PRO n 
1 127 LEU n 
1 128 THR n 
1 129 PRO n 
1 130 GLU n 
1 131 GLY n 
1 132 VAL n 
1 133 HIS n 
1 134 HIS n 
1 135 ASP n 
1 136 GLY n 
1 137 HIS n 
1 138 GLU n 
1 139 PHE n 
1 140 VAL n 
1 141 MET n 
1 142 ILE n 
1 143 ALA n 
1 144 ILE n 
1 145 LEU n 
1 146 ASN n 
1 147 LYS n 
1 148 VAL n 
1 149 ASN n 
1 150 VAL n 
1 151 ALA n 
1 152 GLY n 
1 153 GLY n 
1 154 THR n 
1 155 THR n 
1 156 ARG n 
1 157 LEU n 
1 158 TRP n 
1 159 LYS n 
1 160 PRO n 
1 161 GLY n 
1 162 ALA n 
1 163 ASP n 
1 164 ALA n 
1 165 PRO n 
1 166 PHE n 
1 167 TRP n 
1 168 SER n 
1 169 GLY n 
1 170 THR n 
1 171 LEU n 
1 172 GLU n 
1 173 ALA n 
1 174 GLY n 
1 175 GLN n 
1 176 ALA n 
1 177 VAL n 
1 178 LEU n 
1 179 LEU n 
1 180 ASP n 
1 181 ASP n 
1 182 ARG n 
1 183 GLY n 
1 184 LEU n 
1 185 ALA n 
1 186 HIS n 
1 187 ASP n 
1 188 VAL n 
1 189 THR n 
1 190 ASP n 
1 191 VAL n 
1 192 LEU n 
1 193 SER n 
1 194 ALA n 
1 195 ASP n 
1 196 GLY n 
1 197 GLY n 
1 198 PRO n 
1 199 GLY n 
1 200 HIS n 
1 201 ARG n 
1 202 ASP n 
1 203 ILE n 
1 204 VAL n 
1 205 ILE n 
1 206 ILE n 
1 207 ALA n 
1 208 PHE n 
1 209 SER n 
1 210 ARG n 
1 211 TRP n 
1 212 ALA n 
1 213 GLU n 
1 214 LYS n 
1 215 TRP n 
1 216 TYR n 
1 217 GLY n 
1 218 ASP n 
1 219 GLU n 
1 220 HIS n 
1 221 ASP n 
1 222 ALA n 
1 223 ALA n 
1 224 ALA n 
1 225 LEU n 
1 226 GLU n 
1 227 GLU n 
1 228 GLN n 
1 229 GLU n 
1 230 ALA n 
1 231 HIS n 
1 232 HIS n 
1 233 HIS n 
1 234 HIS n 
1 235 HIS n 
1 236 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   236 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ABE83_05625 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces sp. CFMR 7' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1649184 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACY non-polymer         . 'ACETIC ACID'   ?                 'C2 H4 O2'       60.052  
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION' ?                 'Mg 2'           24.305  
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   PRO 2   2   2   PRO PRO A . n 
A 1 3   LEU 3   3   3   LEU LEU A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   THR 5   5   5   THR THR A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   GLY 7   7   7   GLY GLY A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   THR 9   9   9   THR THR A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  ILE 11  11  11  ILE ILE A . n 
A 1 12  ASP 12  12  12  ASP ASP A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  PRO 14  14  14  PRO PRO A . n 
A 1 15  GLU 15  15  15  GLU GLU A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  ASP 19  19  19  ASP ASP A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ARG 26  26  26  ARG ARG A . n 
A 1 27  CYS 27  27  27  CYS CYS A . n 
A 1 28  PRO 28  28  28  PRO PRO A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  TYR 32  32  32  TYR TYR A . n 
A 1 33  MET 33  33  33  MET MET A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  GLY 36  36  36  GLY GLY A . n 
A 1 37  THR 37  37  37  THR THR A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  PHE 39  39  39  PHE PHE A . n 
A 1 40  LYS 40  40  40  LYS LYS A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  PHE 42  42  42  PHE PHE A . n 
A 1 43  SER 43  43  43  SER SER A . n 
A 1 44  GLN 44  44  44  GLN GLN A . n 
A 1 45  TYR 45  45  45  TYR TYR A . n 
A 1 46  LYS 46  46  46  LYS LYS A . n 
A 1 47  LEU 47  47  47  LEU LEU A . n 
A 1 48  THR 48  48  48  THR THR A . n 
A 1 49  PRO 49  49  49  PRO PRO A . n 
A 1 50  ALA 50  50  50  ALA ALA A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  TRP 55  55  55  TRP TRP A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  PHE 57  57  57  PHE PHE A . n 
A 1 58  LYS 58  58  58  LYS LYS A . n 
A 1 59  ARG 59  59  59  ARG ARG A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  PRO 61  61  61  PRO PRO A . n 
A 1 62  HIS 62  62  62  HIS HIS A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  ASP 64  64  64  ASP ASP A . n 
A 1 65  TYR 65  65  65  TYR TYR A . n 
A 1 66  THR 66  66  66  THR THR A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  TYR 68  68  68  TYR TYR A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  LYS 70  70  70  LYS LYS A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  VAL 74  74  74  VAL VAL A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  GLY 77  77  77  GLY GLY A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  TYR 82  82  82  TYR TYR A . n 
A 1 83  GLU 83  83  83  GLU GLU A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  GLU 86  86  86  GLU GLU A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  ASP 88  88  88  ASP ASP A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  THR 90  90  90  THR THR A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  GLU 99  99  99  GLU GLU A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 LEU 102 102 102 LEU LEU A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 ARG 104 104 104 ARG ARG A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 GLU 106 106 106 GLU GLU A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 GLN 109 109 109 GLN GLN A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 ASN 111 111 111 ASN ASN A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 HIS 113 113 113 HIS HIS A . n 
A 1 114 GLN 114 114 114 GLN GLN A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 ARG 118 118 118 ARG ARG A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 ASP 120 120 120 ASP ASP A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLY 122 122 122 GLY GLY A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 PRO 126 126 126 PRO PRO A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 THR 128 128 128 THR THR A . n 
A 1 129 PRO 129 129 129 PRO PRO A . n 
A 1 130 GLU 130 130 130 GLU GLU A . n 
A 1 131 GLY 131 131 131 GLY GLY A . n 
A 1 132 VAL 132 132 132 VAL VAL A . n 
A 1 133 HIS 133 133 133 HIS HIS A . n 
A 1 134 HIS 134 134 134 HIS HIS A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 VAL 140 140 140 VAL VAL A . n 
A 1 141 MET 141 141 141 MET MET A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ILE 144 144 144 ILE ILE A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 ASN 149 149 149 ASN ASN A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 THR 154 154 154 THR THR A . n 
A 1 155 THR 155 155 155 THR THR A . n 
A 1 156 ARG 156 156 156 ARG ARG A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 TRP 158 158 158 TRP TRP A . n 
A 1 159 LYS 159 159 159 LYS LYS A . n 
A 1 160 PRO 160 160 160 PRO PRO A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 ALA 162 162 162 ALA ALA A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 PHE 166 166 166 PHE PHE A . n 
A 1 167 TRP 167 167 167 TRP TRP A . n 
A 1 168 SER 168 168 168 SER SER A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 THR 170 170 170 THR THR A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 GLU 172 172 172 GLU GLU A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 GLN 175 175 175 GLN GLN A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 ASP 180 180 180 ASP ASP A . n 
A 1 181 ASP 181 181 181 ASP ASP A . n 
A 1 182 ARG 182 182 182 ARG ARG A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 ALA 185 185 185 ALA ALA A . n 
A 1 186 HIS 186 186 186 HIS HIS A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 VAL 188 188 188 VAL VAL A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ASP 190 190 190 ASP ASP A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 GLY 197 197 197 GLY GLY A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ARG 201 201 201 ARG ARG A . n 
A 1 202 ASP 202 202 202 ASP ASP A . n 
A 1 203 ILE 203 203 203 ILE ILE A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ILE 205 205 205 ILE ILE A . n 
A 1 206 ILE 206 206 206 ILE ILE A . n 
A 1 207 ALA 207 207 207 ALA ALA A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 SER 209 209 209 SER SER A . n 
A 1 210 ARG 210 210 210 ARG ARG A . n 
A 1 211 TRP 211 211 211 TRP TRP A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 TRP 215 215 215 TRP TRP A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 GLY 217 217 217 GLY GLY A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 GLU 219 219 219 GLU GLU A . n 
A 1 220 HIS 220 220 220 HIS HIS A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 GLU 226 226 226 GLU GLU A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 GLN 228 228 ?   ?   ?   A . n 
A 1 229 GLU 229 229 ?   ?   ?   A . n 
A 1 230 ALA 230 230 ?   ?   ?   A . n 
A 1 231 HIS 231 231 ?   ?   ?   A . n 
A 1 232 HIS 232 232 ?   ?   ?   A . n 
A 1 233 HIS 233 233 ?   ?   ?   A . n 
A 1 234 HIS 234 234 ?   ?   ?   A . n 
A 1 235 HIS 235 235 ?   ?   ?   A . n 
A 1 236 HIS 236 236 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   PRO 2   2   2   PRO PRO B . n 
B 1 3   LEU 3   3   3   LEU LEU B . n 
B 1 4   GLY 4   4   4   GLY GLY B . n 
B 1 5   THR 5   5   5   THR THR B . n 
B 1 6   GLU 6   6   6   GLU GLU B . n 
B 1 7   GLY 7   7   7   GLY GLY B . n 
B 1 8   PHE 8   8   8   PHE PHE B . n 
B 1 9   THR 9   9   9   THR THR B . n 
B 1 10  VAL 10  10  10  VAL VAL B . n 
B 1 11  ILE 11  11  11  ILE ILE B . n 
B 1 12  ASP 12  12  12  ASP ASP B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  PRO 14  14  14  PRO PRO B . n 
B 1 15  GLU 15  15  15  GLU GLU B . n 
B 1 16  VAL 16  16  16  VAL VAL B . n 
B 1 17  ALA 17  17  17  ALA ALA B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  ASP 19  19  19  ASP ASP B . n 
B 1 20  ILE 20  20  20  ILE ILE B . n 
B 1 21  LEU 21  21  21  LEU LEU B . n 
B 1 22  PRO 22  22  22  PRO PRO B . n 
B 1 23  SER 23  23  23  SER SER B . n 
B 1 24  TYR 24  24  24  TYR TYR B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ARG 26  26  26  ARG ARG B . n 
B 1 27  CYS 27  27  27  CYS CYS B . n 
B 1 28  PRO 28  28  28  PRO PRO B . n 
B 1 29  VAL 29  29  29  VAL VAL B . n 
B 1 30  ASP 30  30  30  ASP ASP B . n 
B 1 31  ASP 31  31  31  ASP ASP B . n 
B 1 32  TYR 32  32  32  TYR TYR B . n 
B 1 33  MET 33  33  33  MET MET B . n 
B 1 34  GLY 34  34  34  GLY GLY B . n 
B 1 35  ASN 35  35  35  ASN ASN B . n 
B 1 36  GLY 36  36  36  GLY GLY B . n 
B 1 37  THR 37  37  37  THR THR B . n 
B 1 38  ARG 38  38  38  ARG ARG B . n 
B 1 39  PHE 39  39  39  PHE PHE B . n 
B 1 40  LYS 40  40  40  LYS LYS B . n 
B 1 41  ARG 41  41  41  ARG ARG B . n 
B 1 42  PHE 42  42  42  PHE PHE B . n 
B 1 43  SER 43  43  43  SER SER B . n 
B 1 44  GLN 44  44  44  GLN GLN B . n 
B 1 45  TYR 45  45  45  TYR TYR B . n 
B 1 46  LYS 46  46  46  LYS LYS B . n 
B 1 47  LEU 47  47  47  LEU LEU B . n 
B 1 48  THR 48  48  48  THR THR B . n 
B 1 49  PRO 49  49  49  PRO PRO B . n 
B 1 50  ALA 50  50  50  ALA ALA B . n 
B 1 51  GLU 51  51  51  GLU GLU B . n 
B 1 52  ASP 52  52  52  ASP ASP B . n 
B 1 53  ASP 53  53  53  ASP ASP B . n 
B 1 54  THR 54  54  54  THR THR B . n 
B 1 55  TRP 55  55  55  TRP TRP B . n 
B 1 56  SER 56  56  56  SER SER B . n 
B 1 57  PHE 57  57  57  PHE PHE B . n 
B 1 58  LYS 58  58  58  LYS LYS B . n 
B 1 59  ARG 59  59  59  ARG ARG B . n 
B 1 60  LEU 60  60  60  LEU LEU B . n 
B 1 61  PRO 61  61  61  PRO PRO B . n 
B 1 62  HIS 62  62  62  HIS HIS B . n 
B 1 63  ARG 63  63  63  ARG ARG B . n 
B 1 64  ASP 64  64  64  ASP ASP B . n 
B 1 65  TYR 65  65  65  TYR TYR B . n 
B 1 66  THR 66  66  66  THR THR B . n 
B 1 67  THR 67  67  67  THR THR B . n 
B 1 68  TYR 68  68  68  TYR TYR B . n 
B 1 69  LYS 69  69  69  LYS LYS B . n 
B 1 70  LYS 70  70  70  LYS LYS B . n 
B 1 71  PHE 71  71  71  PHE PHE B . n 
B 1 72  ASN 72  72  72  ASN ASN B . n 
B 1 73  PRO 73  73  73  PRO PRO B . n 
B 1 74  VAL 74  74  74  VAL VAL B . n 
B 1 75  GLY 75  75  75  GLY GLY B . n 
B 1 76  GLY 76  76  76  GLY GLY B . n 
B 1 77  GLY 77  77  77  GLY GLY B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  ARG 79  79  79  ARG ARG B . n 
B 1 80  ARG 80  80  80  ARG ARG B . n 
B 1 81  VAL 81  81  81  VAL VAL B . n 
B 1 82  TYR 82  82  82  TYR TYR B . n 
B 1 83  GLU 83  83  83  GLU GLU B . n 
B 1 84  PRO 84  84  84  PRO PRO B . n 
B 1 85  ILE 85  85  85  ILE ILE B . n 
B 1 86  GLU 86  86  86  GLU GLU B . n 
B 1 87  VAL 87  87  87  VAL VAL B . n 
B 1 88  ASP 88  88  88  ASP ASP B . n 
B 1 89  PHE 89  89  89  PHE PHE B . n 
B 1 90  THR 90  90  90  THR THR B . n 
B 1 91  PRO 91  91  91  PRO PRO B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ILE 93  93  93  ILE ILE B . n 
B 1 94  SER 94  94  94  SER SER B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  GLY 96  96  96  GLY GLY B . n 
B 1 97  ILE 97  97  97  ILE ILE B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  GLU 99  99  99  GLU GLU B . n 
B 1 100 LEU 100 100 100 LEU LEU B . n 
B 1 101 GLY 101 101 101 GLY GLY B . n 
B 1 102 LEU 102 102 102 LEU LEU B . n 
B 1 103 ASP 103 103 103 ASP ASP B . n 
B 1 104 ARG 104 104 104 ARG ARG B . n 
B 1 105 SER 105 105 105 SER SER B . n 
B 1 106 GLU 106 106 106 GLU GLU B . n 
B 1 107 PRO 107 107 107 PRO PRO B . n 
B 1 108 TRP 108 108 108 TRP TRP B . n 
B 1 109 GLN 109 109 109 GLN GLN B . n 
B 1 110 ILE 110 110 110 ILE ILE B . n 
B 1 111 ASN 111 111 111 ASN ASN B . n 
B 1 112 VAL 112 112 112 VAL VAL B . n 
B 1 113 HIS 113 113 113 HIS HIS B . n 
B 1 114 GLN 114 114 114 GLN GLN B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 THR 117 117 117 THR THR B . n 
B 1 118 ARG 118 118 118 ARG ARG B . n 
B 1 119 ALA 119 119 119 ALA ALA B . n 
B 1 120 ASP 120 120 120 ASP ASP B . n 
B 1 121 GLY 121 121 121 GLY GLY B . n 
B 1 122 GLY 122 122 122 GLY GLY B . n 
B 1 123 ARG 123 123 123 ARG ARG B . n 
B 1 124 PRO 124 124 124 PRO PRO B . n 
B 1 125 GLY 125 125 125 GLY GLY B . n 
B 1 126 PRO 126 126 126 PRO PRO B . n 
B 1 127 LEU 127 127 127 LEU LEU B . n 
B 1 128 THR 128 128 128 THR THR B . n 
B 1 129 PRO 129 129 129 PRO PRO B . n 
B 1 130 GLU 130 130 130 GLU GLU B . n 
B 1 131 GLY 131 131 131 GLY GLY B . n 
B 1 132 VAL 132 132 132 VAL VAL B . n 
B 1 133 HIS 133 133 133 HIS HIS B . n 
B 1 134 HIS 134 134 134 HIS HIS B . n 
B 1 135 ASP 135 135 135 ASP ASP B . n 
B 1 136 GLY 136 136 136 GLY GLY B . n 
B 1 137 HIS 137 137 137 HIS HIS B . n 
B 1 138 GLU 138 138 138 GLU GLU B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 VAL 140 140 140 VAL VAL B . n 
B 1 141 MET 141 141 141 MET MET B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 ALA 143 143 143 ALA ALA B . n 
B 1 144 ILE 144 144 144 ILE ILE B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 ASN 146 146 146 ASN ASN B . n 
B 1 147 LYS 147 147 147 LYS LYS B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 ASN 149 149 149 ASN ASN B . n 
B 1 150 VAL 150 150 150 VAL VAL B . n 
B 1 151 ALA 151 151 151 ALA ALA B . n 
B 1 152 GLY 152 152 152 GLY GLY B . n 
B 1 153 GLY 153 153 153 GLY GLY B . n 
B 1 154 THR 154 154 154 THR THR B . n 
B 1 155 THR 155 155 155 THR THR B . n 
B 1 156 ARG 156 156 156 ARG ARG B . n 
B 1 157 LEU 157 157 157 LEU LEU B . n 
B 1 158 TRP 158 158 158 TRP TRP B . n 
B 1 159 LYS 159 159 159 LYS LYS B . n 
B 1 160 PRO 160 160 160 PRO PRO B . n 
B 1 161 GLY 161 161 161 GLY GLY B . n 
B 1 162 ALA 162 162 162 ALA ALA B . n 
B 1 163 ASP 163 163 163 ASP ASP B . n 
B 1 164 ALA 164 164 164 ALA ALA B . n 
B 1 165 PRO 165 165 165 PRO PRO B . n 
B 1 166 PHE 166 166 166 PHE PHE B . n 
B 1 167 TRP 167 167 167 TRP TRP B . n 
B 1 168 SER 168 168 168 SER SER B . n 
B 1 169 GLY 169 169 169 GLY GLY B . n 
B 1 170 THR 170 170 170 THR THR B . n 
B 1 171 LEU 171 171 171 LEU LEU B . n 
B 1 172 GLU 172 172 172 GLU GLU B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 GLN 175 175 175 GLN GLN B . n 
B 1 176 ALA 176 176 176 ALA ALA B . n 
B 1 177 VAL 177 177 177 VAL VAL B . n 
B 1 178 LEU 178 178 178 LEU LEU B . n 
B 1 179 LEU 179 179 179 LEU LEU B . n 
B 1 180 ASP 180 180 180 ASP ASP B . n 
B 1 181 ASP 181 181 181 ASP ASP B . n 
B 1 182 ARG 182 182 182 ARG ARG B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 ALA 185 185 185 ALA ALA B . n 
B 1 186 HIS 186 186 186 HIS HIS B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 VAL 188 188 188 VAL VAL B . n 
B 1 189 THR 189 189 189 THR THR B . n 
B 1 190 ASP 190 190 190 ASP ASP B . n 
B 1 191 VAL 191 191 191 VAL VAL B . n 
B 1 192 LEU 192 192 192 LEU LEU B . n 
B 1 193 SER 193 193 193 SER SER B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 ASP 195 195 195 ASP ASP B . n 
B 1 196 GLY 196 196 196 GLY GLY B . n 
B 1 197 GLY 197 197 197 GLY GLY B . n 
B 1 198 PRO 198 198 198 PRO PRO B . n 
B 1 199 GLY 199 199 199 GLY GLY B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ARG 201 201 201 ARG ARG B . n 
B 1 202 ASP 202 202 202 ASP ASP B . n 
B 1 203 ILE 203 203 203 ILE ILE B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 ILE 205 205 205 ILE ILE B . n 
B 1 206 ILE 206 206 206 ILE ILE B . n 
B 1 207 ALA 207 207 207 ALA ALA B . n 
B 1 208 PHE 208 208 208 PHE PHE B . n 
B 1 209 SER 209 209 209 SER SER B . n 
B 1 210 ARG 210 210 210 ARG ARG B . n 
B 1 211 TRP 211 211 211 TRP TRP B . n 
B 1 212 ALA 212 212 212 ALA ALA B . n 
B 1 213 GLU 213 213 213 GLU GLU B . n 
B 1 214 LYS 214 214 214 LYS LYS B . n 
B 1 215 TRP 215 215 215 TRP TRP B . n 
B 1 216 TYR 216 216 216 TYR TYR B . n 
B 1 217 GLY 217 217 217 GLY GLY B . n 
B 1 218 ASP 218 218 218 ASP ASP B . n 
B 1 219 GLU 219 219 219 GLU GLU B . n 
B 1 220 HIS 220 220 220 HIS HIS B . n 
B 1 221 ASP 221 221 221 ASP ASP B . n 
B 1 222 ALA 222 222 222 ALA ALA B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 LEU 225 225 225 LEU LEU B . n 
B 1 226 GLU 226 226 226 GLU GLU B . n 
B 1 227 GLU 227 227 ?   ?   ?   B . n 
B 1 228 GLN 228 228 ?   ?   ?   B . n 
B 1 229 GLU 229 229 ?   ?   ?   B . n 
B 1 230 ALA 230 230 ?   ?   ?   B . n 
B 1 231 HIS 231 231 ?   ?   ?   B . n 
B 1 232 HIS 232 232 ?   ?   ?   B . n 
B 1 233 HIS 233 233 ?   ?   ?   B . n 
B 1 234 HIS 234 234 ?   ?   ?   B . n 
B 1 235 HIS 235 235 ?   ?   ?   B . n 
B 1 236 HIS 236 236 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ACY 1   301 301 ACY ACT A . 
D 2 ACY 1   302 302 ACY ACT A . 
E 2 ACY 1   303 303 ACY ACT A . 
F 3 MG  1   304 1   MG  MG  A . 
G 3 MG  1   305 2   MG  MG  A . 
H 3 MG  1   306 3   MG  MG  A . 
I 3 MG  1   307 6   MG  MG  A . 
J 4 EDO 1   301 301 EDO EDO B . 
K 2 ACY 1   302 302 ACY ACT B . 
L 2 ACY 1   303 303 ACY ACT B . 
M 2 ACY 1   304 304 ACY ACT B . 
N 3 MG  1   305 4   MG  MG  B . 
O 3 MG  1   306 5   MG  MG  B . 
P 3 MG  1   307 7   MG  MG  B . 
Q 3 MG  1   308 8   MG  MG  B . 
R 5 HOH 1   401 288 HOH HOH A . 
R 5 HOH 2   402 443 HOH HOH A . 
R 5 HOH 3   403 107 HOH HOH A . 
R 5 HOH 4   404 223 HOH HOH A . 
R 5 HOH 5   405 346 HOH HOH A . 
R 5 HOH 6   406 228 HOH HOH A . 
R 5 HOH 7   407 287 HOH HOH A . 
R 5 HOH 8   408 129 HOH HOH A . 
R 5 HOH 9   409 33  HOH HOH A . 
R 5 HOH 10  410 429 HOH HOH A . 
R 5 HOH 11  411 296 HOH HOH A . 
R 5 HOH 12  412 185 HOH HOH A . 
R 5 HOH 13  413 319 HOH HOH A . 
R 5 HOH 14  414 216 HOH HOH A . 
R 5 HOH 15  415 350 HOH HOH A . 
R 5 HOH 16  416 233 HOH HOH A . 
R 5 HOH 17  417 338 HOH HOH A . 
R 5 HOH 18  418 93  HOH HOH A . 
R 5 HOH 19  419 122 HOH HOH A . 
R 5 HOH 20  420 114 HOH HOH A . 
R 5 HOH 21  421 13  HOH HOH A . 
R 5 HOH 22  422 329 HOH HOH A . 
R 5 HOH 23  423 68  HOH HOH A . 
R 5 HOH 24  424 2   HOH HOH A . 
R 5 HOH 25  425 190 HOH HOH A . 
R 5 HOH 26  426 193 HOH HOH A . 
R 5 HOH 27  427 101 HOH HOH A . 
R 5 HOH 28  428 396 HOH HOH A . 
R 5 HOH 29  429 397 HOH HOH A . 
R 5 HOH 30  430 55  HOH HOH A . 
R 5 HOH 31  431 366 HOH HOH A . 
R 5 HOH 32  432 161 HOH HOH A . 
R 5 HOH 33  433 264 HOH HOH A . 
R 5 HOH 34  434 315 HOH HOH A . 
R 5 HOH 35  435 67  HOH HOH A . 
R 5 HOH 36  436 19  HOH HOH A . 
R 5 HOH 37  437 372 HOH HOH A . 
R 5 HOH 38  438 6   HOH HOH A . 
R 5 HOH 39  439 128 HOH HOH A . 
R 5 HOH 40  440 139 HOH HOH A . 
R 5 HOH 41  441 91  HOH HOH A . 
R 5 HOH 42  442 40  HOH HOH A . 
R 5 HOH 43  443 28  HOH HOH A . 
R 5 HOH 44  444 471 HOH HOH A . 
R 5 HOH 45  445 245 HOH HOH A . 
R 5 HOH 46  446 29  HOH HOH A . 
R 5 HOH 47  447 54  HOH HOH A . 
R 5 HOH 48  448 74  HOH HOH A . 
R 5 HOH 49  449 209 HOH HOH A . 
R 5 HOH 50  450 178 HOH HOH A . 
R 5 HOH 51  451 22  HOH HOH A . 
R 5 HOH 52  452 150 HOH HOH A . 
R 5 HOH 53  453 3   HOH HOH A . 
R 5 HOH 54  454 246 HOH HOH A . 
R 5 HOH 55  455 360 HOH HOH A . 
R 5 HOH 56  456 157 HOH HOH A . 
R 5 HOH 57  457 174 HOH HOH A . 
R 5 HOH 58  458 85  HOH HOH A . 
R 5 HOH 59  459 477 HOH HOH A . 
R 5 HOH 60  460 330 HOH HOH A . 
R 5 HOH 61  461 171 HOH HOH A . 
R 5 HOH 62  462 268 HOH HOH A . 
R 5 HOH 63  463 57  HOH HOH A . 
R 5 HOH 64  464 250 HOH HOH A . 
R 5 HOH 65  465 167 HOH HOH A . 
R 5 HOH 66  466 58  HOH HOH A . 
R 5 HOH 67  467 62  HOH HOH A . 
R 5 HOH 68  468 340 HOH HOH A . 
R 5 HOH 69  469 60  HOH HOH A . 
R 5 HOH 70  470 158 HOH HOH A . 
R 5 HOH 71  471 10  HOH HOH A . 
R 5 HOH 72  472 463 HOH HOH A . 
R 5 HOH 73  473 18  HOH HOH A . 
R 5 HOH 74  474 428 HOH HOH A . 
R 5 HOH 75  475 304 HOH HOH A . 
R 5 HOH 76  476 90  HOH HOH A . 
R 5 HOH 77  477 44  HOH HOH A . 
R 5 HOH 78  478 20  HOH HOH A . 
R 5 HOH 79  479 37  HOH HOH A . 
R 5 HOH 80  480 286 HOH HOH A . 
R 5 HOH 81  481 147 HOH HOH A . 
R 5 HOH 82  482 16  HOH HOH A . 
R 5 HOH 83  483 43  HOH HOH A . 
R 5 HOH 84  484 69  HOH HOH A . 
R 5 HOH 85  485 207 HOH HOH A . 
R 5 HOH 86  486 31  HOH HOH A . 
R 5 HOH 87  487 309 HOH HOH A . 
R 5 HOH 88  488 317 HOH HOH A . 
R 5 HOH 89  489 1   HOH HOH A . 
R 5 HOH 90  490 141 HOH HOH A . 
R 5 HOH 91  491 4   HOH HOH A . 
R 5 HOH 92  492 94  HOH HOH A . 
R 5 HOH 93  493 42  HOH HOH A . 
R 5 HOH 94  494 104 HOH HOH A . 
R 5 HOH 95  495 71  HOH HOH A . 
R 5 HOH 96  496 237 HOH HOH A . 
R 5 HOH 97  497 52  HOH HOH A . 
R 5 HOH 98  498 333 HOH HOH A . 
R 5 HOH 99  499 211 HOH HOH A . 
R 5 HOH 100 500 32  HOH HOH A . 
R 5 HOH 101 501 226 HOH HOH A . 
R 5 HOH 102 502 27  HOH HOH A . 
R 5 HOH 103 503 15  HOH HOH A . 
R 5 HOH 104 504 106 HOH HOH A . 
R 5 HOH 105 505 35  HOH HOH A . 
R 5 HOH 106 506 24  HOH HOH A . 
R 5 HOH 107 507 121 HOH HOH A . 
R 5 HOH 108 508 289 HOH HOH A . 
R 5 HOH 109 509 113 HOH HOH A . 
R 5 HOH 110 510 217 HOH HOH A . 
R 5 HOH 111 511 445 HOH HOH A . 
R 5 HOH 112 512 17  HOH HOH A . 
R 5 HOH 113 513 170 HOH HOH A . 
R 5 HOH 114 514 285 HOH HOH A . 
R 5 HOH 115 515 138 HOH HOH A . 
R 5 HOH 116 516 394 HOH HOH A . 
R 5 HOH 117 517 231 HOH HOH A . 
R 5 HOH 118 518 169 HOH HOH A . 
R 5 HOH 119 519 168 HOH HOH A . 
R 5 HOH 120 520 281 HOH HOH A . 
R 5 HOH 121 521 116 HOH HOH A . 
R 5 HOH 122 522 87  HOH HOH A . 
R 5 HOH 123 523 328 HOH HOH A . 
R 5 HOH 124 524 56  HOH HOH A . 
R 5 HOH 125 525 408 HOH HOH A . 
R 5 HOH 126 526 95  HOH HOH A . 
R 5 HOH 127 527 480 HOH HOH A . 
R 5 HOH 128 528 327 HOH HOH A . 
R 5 HOH 129 529 308 HOH HOH A . 
R 5 HOH 130 530 290 HOH HOH A . 
R 5 HOH 131 531 100 HOH HOH A . 
R 5 HOH 132 532 254 HOH HOH A . 
R 5 HOH 133 533 166 HOH HOH A . 
R 5 HOH 134 534 488 HOH HOH A . 
R 5 HOH 135 535 5   HOH HOH A . 
R 5 HOH 136 536 486 HOH HOH A . 
R 5 HOH 137 537 21  HOH HOH A . 
R 5 HOH 138 538 282 HOH HOH A . 
R 5 HOH 139 539 241 HOH HOH A . 
R 5 HOH 140 540 229 HOH HOH A . 
R 5 HOH 141 541 369 HOH HOH A . 
R 5 HOH 142 542 51  HOH HOH A . 
R 5 HOH 143 543 78  HOH HOH A . 
R 5 HOH 144 544 123 HOH HOH A . 
R 5 HOH 145 545 130 HOH HOH A . 
R 5 HOH 146 546 144 HOH HOH A . 
R 5 HOH 147 547 153 HOH HOH A . 
R 5 HOH 148 548 387 HOH HOH A . 
R 5 HOH 149 549 159 HOH HOH A . 
R 5 HOH 150 550 202 HOH HOH A . 
R 5 HOH 151 551 210 HOH HOH A . 
R 5 HOH 152 552 191 HOH HOH A . 
R 5 HOH 153 553 259 HOH HOH A . 
R 5 HOH 154 554 86  HOH HOH A . 
R 5 HOH 155 555 393 HOH HOH A . 
R 5 HOH 156 556 63  HOH HOH A . 
R 5 HOH 157 557 214 HOH HOH A . 
R 5 HOH 158 558 242 HOH HOH A . 
R 5 HOH 159 559 258 HOH HOH A . 
R 5 HOH 160 560 77  HOH HOH A . 
R 5 HOH 161 561 97  HOH HOH A . 
R 5 HOH 162 562 401 HOH HOH A . 
R 5 HOH 163 563 164 HOH HOH A . 
R 5 HOH 164 564 115 HOH HOH A . 
R 5 HOH 165 565 126 HOH HOH A . 
R 5 HOH 166 566 53  HOH HOH A . 
R 5 HOH 167 567 186 HOH HOH A . 
R 5 HOH 168 568 222 HOH HOH A . 
R 5 HOH 169 569 492 HOH HOH A . 
R 5 HOH 170 570 461 HOH HOH A . 
R 5 HOH 171 571 160 HOH HOH A . 
R 5 HOH 172 572 132 HOH HOH A . 
R 5 HOH 173 573 460 HOH HOH A . 
R 5 HOH 174 574 386 HOH HOH A . 
R 5 HOH 175 575 303 HOH HOH A . 
R 5 HOH 176 576 172 HOH HOH A . 
R 5 HOH 177 577 72  HOH HOH A . 
R 5 HOH 178 578 405 HOH HOH A . 
R 5 HOH 179 579 180 HOH HOH A . 
R 5 HOH 180 580 469 HOH HOH A . 
R 5 HOH 181 581 75  HOH HOH A . 
R 5 HOH 182 582 173 HOH HOH A . 
R 5 HOH 183 583 215 HOH HOH A . 
R 5 HOH 184 584 163 HOH HOH A . 
R 5 HOH 185 585 111 HOH HOH A . 
R 5 HOH 186 586 256 HOH HOH A . 
R 5 HOH 187 587 412 HOH HOH A . 
R 5 HOH 188 588 179 HOH HOH A . 
R 5 HOH 189 589 175 HOH HOH A . 
R 5 HOH 190 590 112 HOH HOH A . 
R 5 HOH 191 591 459 HOH HOH A . 
R 5 HOH 192 592 434 HOH HOH A . 
R 5 HOH 193 593 120 HOH HOH A . 
R 5 HOH 194 594 306 HOH HOH A . 
R 5 HOH 195 595 335 HOH HOH A . 
R 5 HOH 196 596 316 HOH HOH A . 
R 5 HOH 197 597 133 HOH HOH A . 
R 5 HOH 198 598 269 HOH HOH A . 
R 5 HOH 199 599 367 HOH HOH A . 
R 5 HOH 200 600 391 HOH HOH A . 
R 5 HOH 201 601 439 HOH HOH A . 
R 5 HOH 202 602 325 HOH HOH A . 
R 5 HOH 203 603 299 HOH HOH A . 
R 5 HOH 204 604 354 HOH HOH A . 
R 5 HOH 205 605 148 HOH HOH A . 
R 5 HOH 206 606 385 HOH HOH A . 
R 5 HOH 207 607 388 HOH HOH A . 
R 5 HOH 208 608 105 HOH HOH A . 
R 5 HOH 209 609 274 HOH HOH A . 
R 5 HOH 210 610 271 HOH HOH A . 
R 5 HOH 211 611 454 HOH HOH A . 
R 5 HOH 212 612 447 HOH HOH A . 
R 5 HOH 213 613 199 HOH HOH A . 
R 5 HOH 214 614 446 HOH HOH A . 
R 5 HOH 215 615 464 HOH HOH A . 
R 5 HOH 216 616 420 HOH HOH A . 
R 5 HOH 217 617 243 HOH HOH A . 
R 5 HOH 218 618 411 HOH HOH A . 
R 5 HOH 219 619 441 HOH HOH A . 
R 5 HOH 220 620 89  HOH HOH A . 
R 5 HOH 221 621 206 HOH HOH A . 
R 5 HOH 222 622 291 HOH HOH A . 
R 5 HOH 223 623 432 HOH HOH A . 
R 5 HOH 224 624 465 HOH HOH A . 
R 5 HOH 225 625 457 HOH HOH A . 
R 5 HOH 226 626 497 HOH HOH A . 
R 5 HOH 227 627 212 HOH HOH A . 
R 5 HOH 228 628 398 HOH HOH A . 
R 5 HOH 229 629 347 HOH HOH A . 
R 5 HOH 230 630 371 HOH HOH A . 
R 5 HOH 231 631 426 HOH HOH A . 
R 5 HOH 232 632 406 HOH HOH A . 
R 5 HOH 233 633 373 HOH HOH A . 
R 5 HOH 234 634 234 HOH HOH A . 
R 5 HOH 235 635 462 HOH HOH A . 
R 5 HOH 236 636 382 HOH HOH A . 
R 5 HOH 237 637 257 HOH HOH A . 
R 5 HOH 238 638 356 HOH HOH A . 
R 5 HOH 239 639 357 HOH HOH A . 
R 5 HOH 240 640 361 HOH HOH A . 
R 5 HOH 241 641 142 HOH HOH A . 
R 5 HOH 242 642 451 HOH HOH A . 
R 5 HOH 243 643 450 HOH HOH A . 
R 5 HOH 244 644 436 HOH HOH A . 
R 5 HOH 245 645 76  HOH HOH A . 
R 5 HOH 246 646 348 HOH HOH A . 
R 5 HOH 247 647 485 HOH HOH A . 
R 5 HOH 248 648 468 HOH HOH A . 
R 5 HOH 249 649 421 HOH HOH A . 
R 5 HOH 250 650 370 HOH HOH A . 
R 5 HOH 251 651 415 HOH HOH A . 
R 5 HOH 252 652 378 HOH HOH A . 
R 5 HOH 253 653 337 HOH HOH A . 
R 5 HOH 254 654 381 HOH HOH A . 
R 5 HOH 255 655 260 HOH HOH A . 
R 5 HOH 256 656 165 HOH HOH A . 
R 5 HOH 257 657 496 HOH HOH A . 
R 5 HOH 258 658 383 HOH HOH A . 
R 5 HOH 259 659 427 HOH HOH A . 
R 5 HOH 260 660 252 HOH HOH A . 
R 5 HOH 261 661 205 HOH HOH A . 
R 5 HOH 262 662 424 HOH HOH A . 
R 5 HOH 263 663 310 HOH HOH A . 
R 5 HOH 264 664 423 HOH HOH A . 
R 5 HOH 265 665 410 HOH HOH A . 
R 5 HOH 266 666 400 HOH HOH A . 
R 5 HOH 267 667 490 HOH HOH A . 
R 5 HOH 268 668 244 HOH HOH A . 
R 5 HOH 269 669 422 HOH HOH A . 
R 5 HOH 270 670 404 HOH HOH A . 
R 5 HOH 271 671 478 HOH HOH A . 
R 5 HOH 272 672 500 HOH HOH A . 
R 5 HOH 273 673 438 HOH HOH A . 
R 5 HOH 274 674 453 HOH HOH A . 
S 5 HOH 1   401 342 HOH HOH B . 
S 5 HOH 2   402 416 HOH HOH B . 
S 5 HOH 3   403 318 HOH HOH B . 
S 5 HOH 4   404 399 HOH HOH B . 
S 5 HOH 5   405 376 HOH HOH B . 
S 5 HOH 6   406 235 HOH HOH B . 
S 5 HOH 7   407 79  HOH HOH B . 
S 5 HOH 8   408 334 HOH HOH B . 
S 5 HOH 9   409 374 HOH HOH B . 
S 5 HOH 10  410 9   HOH HOH B . 
S 5 HOH 11  411 34  HOH HOH B . 
S 5 HOH 12  412 352 HOH HOH B . 
S 5 HOH 13  413 298 HOH HOH B . 
S 5 HOH 14  414 227 HOH HOH B . 
S 5 HOH 15  415 151 HOH HOH B . 
S 5 HOH 16  416 430 HOH HOH B . 
S 5 HOH 17  417 110 HOH HOH B . 
S 5 HOH 18  418 182 HOH HOH B . 
S 5 HOH 19  419 47  HOH HOH B . 
S 5 HOH 20  420 494 HOH HOH B . 
S 5 HOH 21  421 344 HOH HOH B . 
S 5 HOH 22  422 73  HOH HOH B . 
S 5 HOH 23  423 119 HOH HOH B . 
S 5 HOH 24  424 294 HOH HOH B . 
S 5 HOH 25  425 479 HOH HOH B . 
S 5 HOH 26  426 59  HOH HOH B . 
S 5 HOH 27  427 88  HOH HOH B . 
S 5 HOH 28  428 84  HOH HOH B . 
S 5 HOH 29  429 26  HOH HOH B . 
S 5 HOH 30  430 109 HOH HOH B . 
S 5 HOH 31  431 302 HOH HOH B . 
S 5 HOH 32  432 66  HOH HOH B . 
S 5 HOH 33  433 224 HOH HOH B . 
S 5 HOH 34  434 279 HOH HOH B . 
S 5 HOH 35  435 266 HOH HOH B . 
S 5 HOH 36  436 184 HOH HOH B . 
S 5 HOH 37  437 11  HOH HOH B . 
S 5 HOH 38  438 14  HOH HOH B . 
S 5 HOH 39  439 230 HOH HOH B . 
S 5 HOH 40  440 137 HOH HOH B . 
S 5 HOH 41  441 221 HOH HOH B . 
S 5 HOH 42  442 322 HOH HOH B . 
S 5 HOH 43  443 23  HOH HOH B . 
S 5 HOH 44  444 314 HOH HOH B . 
S 5 HOH 45  445 36  HOH HOH B . 
S 5 HOH 46  446 127 HOH HOH B . 
S 5 HOH 47  447 249 HOH HOH B . 
S 5 HOH 48  448 83  HOH HOH B . 
S 5 HOH 49  449 82  HOH HOH B . 
S 5 HOH 50  450 125 HOH HOH B . 
S 5 HOH 51  451 293 HOH HOH B . 
S 5 HOH 52  452 70  HOH HOH B . 
S 5 HOH 53  453 49  HOH HOH B . 
S 5 HOH 54  454 92  HOH HOH B . 
S 5 HOH 55  455 177 HOH HOH B . 
S 5 HOH 56  456 38  HOH HOH B . 
S 5 HOH 57  457 284 HOH HOH B . 
S 5 HOH 58  458 108 HOH HOH B . 
S 5 HOH 59  459 48  HOH HOH B . 
S 5 HOH 60  460 470 HOH HOH B . 
S 5 HOH 61  461 118 HOH HOH B . 
S 5 HOH 62  462 247 HOH HOH B . 
S 5 HOH 63  463 65  HOH HOH B . 
S 5 HOH 64  464 201 HOH HOH B . 
S 5 HOH 65  465 61  HOH HOH B . 
S 5 HOH 66  466 220 HOH HOH B . 
S 5 HOH 67  467 103 HOH HOH B . 
S 5 HOH 68  468 251 HOH HOH B . 
S 5 HOH 69  469 30  HOH HOH B . 
S 5 HOH 70  470 39  HOH HOH B . 
S 5 HOH 71  471 341 HOH HOH B . 
S 5 HOH 72  472 414 HOH HOH B . 
S 5 HOH 73  473 240 HOH HOH B . 
S 5 HOH 74  474 45  HOH HOH B . 
S 5 HOH 75  475 8   HOH HOH B . 
S 5 HOH 76  476 124 HOH HOH B . 
S 5 HOH 77  477 50  HOH HOH B . 
S 5 HOH 78  478 238 HOH HOH B . 
S 5 HOH 79  479 176 HOH HOH B . 
S 5 HOH 80  480 117 HOH HOH B . 
S 5 HOH 81  481 46  HOH HOH B . 
S 5 HOH 82  482 384 HOH HOH B . 
S 5 HOH 83  483 197 HOH HOH B . 
S 5 HOH 84  484 208 HOH HOH B . 
S 5 HOH 85  485 134 HOH HOH B . 
S 5 HOH 86  486 255 HOH HOH B . 
S 5 HOH 87  487 389 HOH HOH B . 
S 5 HOH 88  488 481 HOH HOH B . 
S 5 HOH 89  489 25  HOH HOH B . 
S 5 HOH 90  490 273 HOH HOH B . 
S 5 HOH 91  491 183 HOH HOH B . 
S 5 HOH 92  492 149 HOH HOH B . 
S 5 HOH 93  493 12  HOH HOH B . 
S 5 HOH 94  494 7   HOH HOH B . 
S 5 HOH 95  495 313 HOH HOH B . 
S 5 HOH 96  496 343 HOH HOH B . 
S 5 HOH 97  497 417 HOH HOH B . 
S 5 HOH 98  498 482 HOH HOH B . 
S 5 HOH 99  499 239 HOH HOH B . 
S 5 HOH 100 500 323 HOH HOH B . 
S 5 HOH 101 501 162 HOH HOH B . 
S 5 HOH 102 502 262 HOH HOH B . 
S 5 HOH 103 503 152 HOH HOH B . 
S 5 HOH 104 504 402 HOH HOH B . 
S 5 HOH 105 505 80  HOH HOH B . 
S 5 HOH 106 506 98  HOH HOH B . 
S 5 HOH 107 507 102 HOH HOH B . 
S 5 HOH 108 508 301 HOH HOH B . 
S 5 HOH 109 509 96  HOH HOH B . 
S 5 HOH 110 510 267 HOH HOH B . 
S 5 HOH 111 511 225 HOH HOH B . 
S 5 HOH 112 512 181 HOH HOH B . 
S 5 HOH 113 513 200 HOH HOH B . 
S 5 HOH 114 514 145 HOH HOH B . 
S 5 HOH 115 515 204 HOH HOH B . 
S 5 HOH 116 516 131 HOH HOH B . 
S 5 HOH 117 517 156 HOH HOH B . 
S 5 HOH 118 518 263 HOH HOH B . 
S 5 HOH 119 519 140 HOH HOH B . 
S 5 HOH 120 520 136 HOH HOH B . 
S 5 HOH 121 521 41  HOH HOH B . 
S 5 HOH 122 522 474 HOH HOH B . 
S 5 HOH 123 523 321 HOH HOH B . 
S 5 HOH 124 524 295 HOH HOH B . 
S 5 HOH 125 525 143 HOH HOH B . 
S 5 HOH 126 526 270 HOH HOH B . 
S 5 HOH 127 527 155 HOH HOH B . 
S 5 HOH 128 528 324 HOH HOH B . 
S 5 HOH 129 529 194 HOH HOH B . 
S 5 HOH 130 530 379 HOH HOH B . 
S 5 HOH 131 531 99  HOH HOH B . 
S 5 HOH 132 532 435 HOH HOH B . 
S 5 HOH 133 533 307 HOH HOH B . 
S 5 HOH 134 534 146 HOH HOH B . 
S 5 HOH 135 535 489 HOH HOH B . 
S 5 HOH 136 536 135 HOH HOH B . 
S 5 HOH 137 537 297 HOH HOH B . 
S 5 HOH 138 538 196 HOH HOH B . 
S 5 HOH 139 539 413 HOH HOH B . 
S 5 HOH 140 540 198 HOH HOH B . 
S 5 HOH 141 541 189 HOH HOH B . 
S 5 HOH 142 542 187 HOH HOH B . 
S 5 HOH 143 543 275 HOH HOH B . 
S 5 HOH 144 544 390 HOH HOH B . 
S 5 HOH 145 545 272 HOH HOH B . 
S 5 HOH 146 546 261 HOH HOH B . 
S 5 HOH 147 547 311 HOH HOH B . 
S 5 HOH 148 548 154 HOH HOH B . 
S 5 HOH 149 549 195 HOH HOH B . 
S 5 HOH 150 550 448 HOH HOH B . 
S 5 HOH 151 551 358 HOH HOH B . 
S 5 HOH 152 552 487 HOH HOH B . 
S 5 HOH 153 553 265 HOH HOH B . 
S 5 HOH 154 554 253 HOH HOH B . 
S 5 HOH 155 555 363 HOH HOH B . 
S 5 HOH 156 556 440 HOH HOH B . 
S 5 HOH 157 557 362 HOH HOH B . 
S 5 HOH 158 558 300 HOH HOH B . 
S 5 HOH 159 559 64  HOH HOH B . 
S 5 HOH 160 560 407 HOH HOH B . 
S 5 HOH 161 561 365 HOH HOH B . 
S 5 HOH 162 562 458 HOH HOH B . 
S 5 HOH 163 563 353 HOH HOH B . 
S 5 HOH 164 564 375 HOH HOH B . 
S 5 HOH 165 565 276 HOH HOH B . 
S 5 HOH 166 566 81  HOH HOH B . 
S 5 HOH 167 567 380 HOH HOH B . 
S 5 HOH 168 568 483 HOH HOH B . 
S 5 HOH 169 569 493 HOH HOH B . 
S 5 HOH 170 570 498 HOH HOH B . 
S 5 HOH 171 571 332 HOH HOH B . 
S 5 HOH 172 572 395 HOH HOH B . 
S 5 HOH 173 573 475 HOH HOH B . 
S 5 HOH 174 574 392 HOH HOH B . 
S 5 HOH 175 575 355 HOH HOH B . 
S 5 HOH 176 576 466 HOH HOH B . 
S 5 HOH 177 577 278 HOH HOH B . 
S 5 HOH 178 578 364 HOH HOH B . 
S 5 HOH 179 579 495 HOH HOH B . 
S 5 HOH 180 580 476 HOH HOH B . 
S 5 HOH 181 581 320 HOH HOH B . 
S 5 HOH 182 582 305 HOH HOH B . 
S 5 HOH 183 583 456 HOH HOH B . 
S 5 HOH 184 584 455 HOH HOH B . 
S 5 HOH 185 585 425 HOH HOH B . 
S 5 HOH 186 586 359 HOH HOH B . 
S 5 HOH 187 587 188 HOH HOH B . 
S 5 HOH 188 588 336 HOH HOH B . 
S 5 HOH 189 589 368 HOH HOH B . 
S 5 HOH 190 590 218 HOH HOH B . 
S 5 HOH 191 591 326 HOH HOH B . 
S 5 HOH 192 592 431 HOH HOH B . 
S 5 HOH 193 593 203 HOH HOH B . 
S 5 HOH 194 594 442 HOH HOH B . 
S 5 HOH 195 595 292 HOH HOH B . 
S 5 HOH 196 596 452 HOH HOH B . 
S 5 HOH 197 597 248 HOH HOH B . 
S 5 HOH 198 598 403 HOH HOH B . 
S 5 HOH 199 599 351 HOH HOH B . 
S 5 HOH 200 600 419 HOH HOH B . 
S 5 HOH 201 601 277 HOH HOH B . 
S 5 HOH 202 602 484 HOH HOH B . 
S 5 HOH 203 603 349 HOH HOH B . 
S 5 HOH 204 604 192 HOH HOH B . 
S 5 HOH 205 605 236 HOH HOH B . 
S 5 HOH 206 606 444 HOH HOH B . 
S 5 HOH 207 607 433 HOH HOH B . 
S 5 HOH 208 608 280 HOH HOH B . 
S 5 HOH 209 609 449 HOH HOH B . 
S 5 HOH 210 610 345 HOH HOH B . 
S 5 HOH 211 611 219 HOH HOH B . 
S 5 HOH 212 612 232 HOH HOH B . 
S 5 HOH 213 613 409 HOH HOH B . 
S 5 HOH 214 614 499 HOH HOH B . 
S 5 HOH 215 615 491 HOH HOH B . 
S 5 HOH 216 616 339 HOH HOH B . 
S 5 HOH 217 617 283 HOH HOH B . 
S 5 HOH 218 618 331 HOH HOH B . 
S 5 HOH 219 619 472 HOH HOH B . 
S 5 HOH 220 620 312 HOH HOH B . 
S 5 HOH 221 621 377 HOH HOH B . 
S 5 HOH 222 622 473 HOH HOH B . 
S 5 HOH 223 623 501 HOH HOH B . 
S 5 HOH 224 624 213 HOH HOH B . 
S 5 HOH 225 625 467 HOH HOH B . 
S 5 HOH 226 626 418 HOH HOH B . 
S 5 HOH 227 627 437 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.21 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? .    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .    4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.609 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DQ0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     44.496 
_cell.length_a_esd                 ? 
_cell.length_b                     75.033 
_cell.length_b_esd                 ? 
_cell.length_c                     86.568 
_cell.length_c_esd                 ? 
_cell.volume                       289009.197 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DQ0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DQ0 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.73 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.89 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M magnesium acetate; 0.1 M sodium cacodylate; pH 6.5; 20% (w/v) PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-01-24 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-D' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          16.13 
_reflns.entry_id                                       9DQ0 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               17.71 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38520 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.988 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.154 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2860 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.866 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.56 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DQ0 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             17.71 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38497 
_refine.ls_number_reflns_R_free                  1921 
_refine.ls_number_reflns_R_work                  36576 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.85 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1886 
_refine.ls_R_factor_R_free                       0.2246 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1867 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.6137 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2158 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        17.71 
_refine_hist.number_atoms_solvent             501 
_refine_hist.number_atoms_total               4092 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3555 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         36 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0080  ? 3705 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0269  ? 5045 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0625  ? 525  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0109  ? 675  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.6599 ? 1352 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.05  . . 124 2626 99.82  . . . . 0.2212 . . . . . . . . . . . 0.3051 
'X-RAY DIFFRACTION' 2.05 2.11  . . 124 2608 100.00 . . . . 0.1964 . . . . . . . . . . . 0.2705 
'X-RAY DIFFRACTION' 2.11 2.17  . . 132 2611 100.00 . . . . 0.2008 . . . . . . . . . . . 0.2428 
'X-RAY DIFFRACTION' 2.17 2.24  . . 130 2633 99.96  . . . . 0.1972 . . . . . . . . . . . 0.2667 
'X-RAY DIFFRACTION' 2.24 2.32  . . 153 2563 99.96  . . . . 0.1956 . . . . . . . . . . . 0.2957 
'X-RAY DIFFRACTION' 2.32 2.41  . . 141 2595 100.00 . . . . 0.2034 . . . . . . . . . . . 0.2394 
'X-RAY DIFFRACTION' 2.41 2.52  . . 135 2605 100.00 . . . . 0.2003 . . . . . . . . . . . 0.2669 
'X-RAY DIFFRACTION' 2.52 2.65  . . 155 2592 99.96  . . . . 0.1986 . . . . . . . . . . . 0.2348 
'X-RAY DIFFRACTION' 2.65 2.82  . . 132 2611 99.96  . . . . 0.1976 . . . . . . . . . . . 0.2772 
'X-RAY DIFFRACTION' 2.82 3.03  . . 105 2652 99.93  . . . . 0.2001 . . . . . . . . . . . 0.2028 
'X-RAY DIFFRACTION' 3.03 3.34  . . 145 2609 99.82  . . . . 0.1868 . . . . . . . . . . . 0.2295 
'X-RAY DIFFRACTION' 3.34 3.81  . . 161 2588 99.64  . . . . 0.1684 . . . . . . . . . . . 0.1963 
'X-RAY DIFFRACTION' 3.82 4.79  . . 130 2626 99.46  . . . . 0.1541 . . . . . . . . . . . 0.1807 
'X-RAY DIFFRACTION' 4.79 17.71 . . 154 2657 99.36  . . . . 0.1794 . . . . . . . . . . . 0.1683 
# 
_struct.entry_id                     9DQ0 
_struct.title                        'Crystal structure of apo HrmJ from Streptomyces sp. CFMR 7' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DQ0 
_struct_keywords.text            'cyclopropanase, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 4 ? 
K N N 2 ? 
L N N 2 ? 
M N N 2 ? 
N N N 3 ? 
O N N 3 ? 
P N N 3 ? 
Q N N 3 ? 
R N N 5 ? 
S N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0M5J3M0_9ACTN 
_struct_ref.pdbx_db_accession          A0A0M5J3M0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MPLGTEGFTVIDLPEVAPDILPSYDRCPVDDYMGNGTRFKRFSQYKLTPAEDDTWSFKRLPHRDYTTYKKFNPVGGGIRR
VYEPIEVDFTPLISEGIRELGLDRSEPWQINVHQNRTRADGGRPGPLTPEGVHHDGHEFVMIAILNKVNVAGGTTRLWKP
GADAPFWSGTLEAGQAVLLDDRGLAHDVTDVLSADGGPGHRDIVIIAFSRWAEKWYGDEHDAAALEEQEA
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DQ0 A 1 ? 230 ? A0A0M5J3M0 1 ? 230 ? 1 230 
2 1 9DQ0 B 1 ? 230 ? A0A0M5J3M0 1 ? 230 ? 1 230 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DQ0 HIS A 231 ? UNP A0A0M5J3M0 ? ? 'expression tag' 231 1  
1 9DQ0 HIS A 232 ? UNP A0A0M5J3M0 ? ? 'expression tag' 232 2  
1 9DQ0 HIS A 233 ? UNP A0A0M5J3M0 ? ? 'expression tag' 233 3  
1 9DQ0 HIS A 234 ? UNP A0A0M5J3M0 ? ? 'expression tag' 234 4  
1 9DQ0 HIS A 235 ? UNP A0A0M5J3M0 ? ? 'expression tag' 235 5  
1 9DQ0 HIS A 236 ? UNP A0A0M5J3M0 ? ? 'expression tag' 236 6  
2 9DQ0 HIS B 231 ? UNP A0A0M5J3M0 ? ? 'expression tag' 231 7  
2 9DQ0 HIS B 232 ? UNP A0A0M5J3M0 ? ? 'expression tag' 232 8  
2 9DQ0 HIS B 233 ? UNP A0A0M5J3M0 ? ? 'expression tag' 233 9  
2 9DQ0 HIS B 234 ? UNP A0A0M5J3M0 ? ? 'expression tag' 234 10 
2 9DQ0 HIS B 235 ? UNP A0A0M5J3M0 ? ? 'expression tag' 235 11 
2 9DQ0 HIS B 236 ? UNP A0A0M5J3M0 ? ? 'expression tag' 236 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 19  ? TYR A 24  ? ASP A 19  TYR A 24  1 ? 6  
HELX_P HELX_P2  AA2 ASP A 25  ? CYS A 27  ? ASP A 25  CYS A 27  5 ? 3  
HELX_P HELX_P3  AA3 PHE A 89  ? GLY A 101 ? PHE A 89  GLY A 101 1 ? 13 
HELX_P HELX_P4  AA4 ALA A 212 ? LYS A 214 ? ALA A 212 LYS A 214 5 ? 3  
HELX_P HELX_P5  AA5 GLY A 217 ? GLU A 226 ? GLY A 217 GLU A 226 1 ? 10 
HELX_P HELX_P6  AA6 ASP B 19  ? TYR B 24  ? ASP B 19  TYR B 24  1 ? 6  
HELX_P HELX_P7  AA7 ASP B 25  ? CYS B 27  ? ASP B 25  CYS B 27  5 ? 3  
HELX_P HELX_P8  AA8 PHE B 89  ? GLY B 101 ? PHE B 89  GLY B 101 1 ? 13 
HELX_P HELX_P9  AA9 ALA B 212 ? LYS B 214 ? ALA B 212 LYS B 214 5 ? 3  
HELX_P HELX_P10 AB1 GLY B 217 ? GLU B 226 ? GLY B 217 GLU B 226 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A TYR 65  OH  ? ? ? 1_555 G MG  . MG ? ? A TYR 65  A MG  305 1_555 ? ? ? ? ? ? ? 2.663 ? ? 
metalc2  metalc ? ? A THR 67  OG1 ? ? ? 1_555 F MG  . MG ? ? A THR 67  A MG  304 1_555 ? ? ? ? ? ? ? 2.752 ? ? 
metalc3  metalc ? ? A ASP 135 O   ? ? ? 1_555 F MG  . MG ? ? A ASP 135 A MG  304 1_555 ? ? ? ? ? ? ? 2.624 ? ? 
metalc4  metalc ? ? C ACY .   O   ? ? ? 1_555 F MG  . MG ? ? A ACY 301 A MG  304 1_555 ? ? ? ? ? ? ? 2.596 ? ? 
metalc5  metalc ? ? D ACY .   O   ? ? ? 1_555 G MG  . MG ? ? A ACY 302 A MG  305 1_555 ? ? ? ? ? ? ? 2.536 ? ? 
metalc6  metalc ? ? E ACY .   O   ? ? ? 1_555 H MG  . MG ? ? A ACY 303 A MG  306 1_555 ? ? ? ? ? ? ? 2.653 ? ? 
metalc7  metalc ? ? F MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  304 A HOH 605 1_555 ? ? ? ? ? ? ? 2.460 ? ? 
metalc8  metalc ? ? G MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  305 A HOH 605 1_555 ? ? ? ? ? ? ? 2.705 ? ? 
metalc9  metalc ? ? H MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  306 A HOH 491 1_555 ? ? ? ? ? ? ? 2.770 ? ? 
metalc10 metalc ? ? H MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  306 A HOH 581 1_555 ? ? ? ? ? ? ? 2.731 ? ? 
metalc11 metalc ? ? R HOH .   O   ? ? ? 1_555 P MG  . MG ? ? A HOH 538 B MG  307 1_555 ? ? ? ? ? ? ? 2.819 ? ? 
metalc12 metalc ? ? B ASP 30  OD2 ? ? ? 1_555 Q MG  . MG ? ? B ASP 30  B MG  308 1_555 ? ? ? ? ? ? ? 2.800 ? ? 
metalc13 metalc ? ? B THR 67  OG1 ? ? ? 1_555 O MG  . MG ? ? B THR 67  B MG  306 1_555 ? ? ? ? ? ? ? 2.807 ? ? 
metalc14 metalc ? ? B ASP 135 O   ? ? ? 1_555 O MG  . MG ? ? B ASP 135 B MG  306 1_555 ? ? ? ? ? ? ? 2.733 ? ? 
metalc15 metalc ? ? K ACY .   O   ? ? ? 1_555 N MG  . MG ? ? B ACY 302 B MG  305 1_555 ? ? ? ? ? ? ? 2.676 ? ? 
metalc16 metalc ? ? L ACY .   O   ? ? ? 1_555 O MG  . MG ? ? B ACY 303 B MG  306 1_555 ? ? ? ? ? ? ? 2.476 ? ? 
metalc17 metalc ? ? M ACY .   O   ? ? ? 1_555 Q MG  . MG ? ? B ACY 304 B MG  308 1_555 ? ? ? ? ? ? ? 2.782 ? ? 
metalc18 metalc ? ? M ACY .   OXT ? ? ? 1_555 Q MG  . MG ? ? B ACY 304 B MG  308 1_555 ? ? ? ? ? ? ? 2.613 ? ? 
metalc19 metalc ? ? N MG  .   MG  ? ? ? 1_555 S HOH . O  ? ? B MG  305 B HOH 493 1_555 ? ? ? ? ? ? ? 2.692 ? ? 
metalc20 metalc ? ? N MG  .   MG  ? ? ? 1_555 S HOH . O  ? ? B MG  305 B HOH 566 1_555 ? ? ? ? ? ? ? 2.990 ? ? 
metalc21 metalc ? ? O MG  .   MG  ? ? ? 1_555 S HOH . O  ? ? B MG  306 B HOH 577 1_555 ? ? ? ? ? ? ? 2.643 ? ? 
metalc22 metalc ? ? P MG  .   MG  ? ? ? 1_555 S HOH . O  ? ? B MG  307 B HOH 534 1_555 ? ? ? ? ? ? ? 2.900 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OH  ? A TYR 65  ? A TYR 65  ? 1_555 MG ? G MG . ? A MG 305 ? 1_555 O   ? D ACY .   ? A ACY 302 ? 1_555 116.1 ? 
2  OH  ? A TYR 65  ? A TYR 65  ? 1_555 MG ? G MG . ? A MG 305 ? 1_555 O   ? R HOH .   ? A HOH 605 ? 1_555 77.1  ? 
3  O   ? D ACY .   ? A ACY 302 ? 1_555 MG ? G MG . ? A MG 305 ? 1_555 O   ? R HOH .   ? A HOH 605 ? 1_555 128.4 ? 
4  OG1 ? A THR 67  ? A THR 67  ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? A ASP 135 ? A ASP 135 ? 1_555 108.3 ? 
5  OG1 ? A THR 67  ? A THR 67  ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? C ACY .   ? A ACY 301 ? 1_555 109.8 ? 
6  O   ? A ASP 135 ? A ASP 135 ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? C ACY .   ? A ACY 301 ? 1_555 103.0 ? 
7  OG1 ? A THR 67  ? A THR 67  ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? R HOH .   ? A HOH 605 ? 1_555 96.8  ? 
8  O   ? A ASP 135 ? A ASP 135 ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? R HOH .   ? A HOH 605 ? 1_555 126.0 ? 
9  O   ? C ACY .   ? A ACY 301 ? 1_555 MG ? F MG . ? A MG 304 ? 1_555 O   ? R HOH .   ? A HOH 605 ? 1_555 112.4 ? 
10 O   ? E ACY .   ? A ACY 303 ? 1_555 MG ? H MG . ? A MG 306 ? 1_555 O   ? R HOH .   ? A HOH 491 ? 1_555 105.9 ? 
11 O   ? E ACY .   ? A ACY 303 ? 1_555 MG ? H MG . ? A MG 306 ? 1_555 O   ? R HOH .   ? A HOH 581 ? 1_555 116.0 ? 
12 O   ? R HOH .   ? A HOH 491 ? 1_555 MG ? H MG . ? A MG 306 ? 1_555 O   ? R HOH .   ? A HOH 581 ? 1_555 134.1 ? 
13 O   ? R HOH .   ? A HOH 538 ? 1_555 MG ? P MG . ? B MG 307 ? 1_555 O   ? S HOH .   ? B HOH 534 ? 1_555 90.5  ? 
14 OD2 ? B ASP 30  ? B ASP 30  ? 1_555 MG ? Q MG . ? B MG 308 ? 1_555 O   ? M ACY .   ? B ACY 304 ? 1_555 150.1 ? 
15 OD2 ? B ASP 30  ? B ASP 30  ? 1_555 MG ? Q MG . ? B MG 308 ? 1_555 OXT ? M ACY .   ? B ACY 304 ? 1_555 152.4 ? 
16 O   ? M ACY .   ? B ACY 304 ? 1_555 MG ? Q MG . ? B MG 308 ? 1_555 OXT ? M ACY .   ? B ACY 304 ? 1_555 49.0  ? 
17 OG1 ? B THR 67  ? B THR 67  ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? B ASP 135 ? B ASP 135 ? 1_555 104.6 ? 
18 OG1 ? B THR 67  ? B THR 67  ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? L ACY .   ? B ACY 303 ? 1_555 114.1 ? 
19 O   ? B ASP 135 ? B ASP 135 ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? L ACY .   ? B ACY 303 ? 1_555 101.4 ? 
20 OG1 ? B THR 67  ? B THR 67  ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? S HOH .   ? B HOH 577 ? 1_555 104.1 ? 
21 O   ? B ASP 135 ? B ASP 135 ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? S HOH .   ? B HOH 577 ? 1_555 118.7 ? 
22 O   ? L ACY .   ? B ACY 303 ? 1_555 MG ? O MG . ? B MG 306 ? 1_555 O   ? S HOH .   ? B HOH 577 ? 1_555 114.1 ? 
23 O   ? K ACY .   ? B ACY 302 ? 1_555 MG ? N MG . ? B MG 305 ? 1_555 O   ? S HOH .   ? B HOH 493 ? 1_555 106.4 ? 
24 O   ? K ACY .   ? B ACY 302 ? 1_555 MG ? N MG . ? B MG 305 ? 1_555 O   ? S HOH .   ? B HOH 566 ? 1_555 115.8 ? 
25 O   ? S HOH .   ? B HOH 493 ? 1_555 MG ? N MG . ? B MG 305 ? 1_555 O   ? S HOH .   ? B HOH 566 ? 1_555 126.8 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? ASP A 12  ? PHE A 8   ASP A 12  
AA1 2 GLN A 175 ? ASP A 180 ? GLN A 175 ASP A 180 
AA1 3 PHE A 139 ? VAL A 148 ? PHE A 139 VAL A 148 
AA1 4 GLY A 199 ? ARG A 210 ? GLY A 199 ARG A 210 
AA1 5 TRP A 108 ? ALA A 119 ? TRP A 108 ALA A 119 
AA1 6 ARG A 38  ? ALA A 50  ? ARG A 38  ALA A 50  
AA1 7 THR A 54  ? ARG A 59  ? THR A 54  ARG A 59  
AA2 1 VAL A 150 ? GLY A 152 ? VAL A 150 GLY A 152 
AA2 2 VAL A 191 ? SER A 193 ? VAL A 191 SER A 193 
AA3 1 TRP A 167 ? THR A 170 ? TRP A 167 THR A 170 
AA3 2 THR A 154 ? TRP A 158 ? THR A 154 TRP A 158 
AA3 3 ALA A 185 ? VAL A 188 ? ALA A 185 VAL A 188 
AA4 1 PHE B 8   ? ASP B 12  ? PHE B 8   ASP B 12  
AA4 2 GLN B 175 ? ASP B 180 ? GLN B 175 ASP B 180 
AA4 3 PHE B 139 ? VAL B 148 ? PHE B 139 VAL B 148 
AA4 4 GLY B 199 ? ARG B 210 ? GLY B 199 ARG B 210 
AA4 5 TRP B 108 ? ALA B 119 ? TRP B 108 ALA B 119 
AA4 6 ARG B 38  ? ALA B 50  ? ARG B 38  ALA B 50  
AA4 7 THR B 54  ? ARG B 59  ? THR B 54  ARG B 59  
AA5 1 VAL B 150 ? GLY B 152 ? VAL B 150 GLY B 152 
AA5 2 VAL B 191 ? SER B 193 ? VAL B 191 SER B 193 
AA6 1 TRP B 167 ? GLY B 169 ? TRP B 167 GLY B 169 
AA6 2 THR B 155 ? TRP B 158 ? THR B 155 TRP B 158 
AA6 3 ALA B 185 ? VAL B 188 ? ALA B 185 VAL B 188 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 11  ? N ILE A 11  O ALA A 176 ? O ALA A 176 
AA1 2 3 O GLN A 175 ? O GLN A 175 N ILE A 144 ? N ILE A 144 
AA1 3 4 N ASN A 146 ? N ASN A 146 O ASP A 202 ? O ASP A 202 
AA1 4 5 O SER A 209 ? O SER A 209 N GLN A 109 ? N GLN A 109 
AA1 5 6 O TRP A 108 ? O TRP A 108 N LEU A 47  ? N LEU A 47  
AA1 6 7 N ALA A 50  ? N ALA A 50  O THR A 54  ? O THR A 54  
AA2 1 2 N ALA A 151 ? N ALA A 151 O LEU A 192 ? O LEU A 192 
AA3 1 2 O TRP A 167 ? O TRP A 167 N LEU A 157 ? N LEU A 157 
AA3 2 3 N ARG A 156 ? N ARG A 156 O ASP A 187 ? O ASP A 187 
AA4 1 2 N THR B 9   ? N THR B 9   O LEU B 178 ? O LEU B 178 
AA4 2 3 O GLN B 175 ? O GLN B 175 N ILE B 144 ? N ILE B 144 
AA4 3 4 N ASN B 146 ? N ASN B 146 O ASP B 202 ? O ASP B 202 
AA4 4 5 O SER B 209 ? O SER B 209 N GLN B 109 ? N GLN B 109 
AA4 5 6 O TRP B 108 ? O TRP B 108 N LEU B 47  ? N LEU B 47  
AA4 6 7 N ALA B 50  ? N ALA B 50  O THR B 54  ? O THR B 54  
AA5 1 2 N ALA B 151 ? N ALA B 151 O LEU B 192 ? O LEU B 192 
AA6 1 2 O TRP B 167 ? O TRP B 167 N LEU B 157 ? N LEU B 157 
AA6 2 3 N ARG B 156 ? N ARG B 156 O ASP B 187 ? O ASP B 187 
# 
_pdbx_entry_details.entry_id                   9DQ0 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O B HOH 563 ? ? O B HOH 575 ? ? 2.05 
2  1 O B HOH 436 ? ? O B HOH 579 ? ? 2.07 
3  1 O A HOH 439 ? ? O A HOH 540 ? ? 2.07 
4  1 O B HOH 508 ? ? O B HOH 557 ? ? 2.08 
5  1 O B HOH 561 ? ? O B HOH 593 ? ? 2.10 
6  1 O A HOH 413 ? ? O A HOH 639 ? ? 2.11 
7  1 O A HOH 419 ? ? O A HOH 613 ? ? 2.12 
8  1 O A HOH 412 ? ? O A HOH 599 ? ? 2.12 
9  1 O A SER 105 ? ? O A HOH 401 ? ? 2.12 
10 1 O B HOH 421 ? ? O B HOH 602 ? ? 2.13 
11 1 O B HOH 447 ? ? O B HOH 528 ? ? 2.14 
12 1 O B HOH 526 ? ? O B HOH 593 ? ? 2.14 
13 1 O B HOH 403 ? ? O B HOH 595 ? ? 2.16 
14 1 O B HOH 572 ? ? O B HOH 601 ? ? 2.16 
15 1 O A HOH 588 ? ? O A HOH 600 ? ? 2.18 
16 1 O B HOH 484 ? ? O B HOH 581 ? ? 2.18 
17 1 O A HOH 673 ? ? O A HOH 674 ? ? 2.19 
18 1 O B HOH 499 ? ? O B HOH 584 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    B 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     541 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     552 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_555 
_pdbx_validate_symm_contact.dist              2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 52  ? ? 72.47  31.72   
2 1 TRP A 215 ? ? -92.33 54.26   
3 1 THR B 5   ? ? 65.34  -51.33  
4 1 GLU B 51  ? ? 64.11  -136.99 
5 1 TRP B 215 ? ? -94.16 49.99   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 672 ? 6.03 . 
2 1 O ? A HOH 673 ? 6.57 . 
3 1 O ? A HOH 674 ? 6.58 . 
4 1 O ? B HOH 627 ? 6.83 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A GLN 228 ? A GLN 228 
3  1 Y 1 A GLU 229 ? A GLU 229 
4  1 Y 1 A ALA 230 ? A ALA 230 
5  1 Y 1 A HIS 231 ? A HIS 231 
6  1 Y 1 A HIS 232 ? A HIS 232 
7  1 Y 1 A HIS 233 ? A HIS 233 
8  1 Y 1 A HIS 234 ? A HIS 234 
9  1 Y 1 A HIS 235 ? A HIS 235 
10 1 Y 1 A HIS 236 ? A HIS 236 
11 1 Y 1 B MET 1   ? B MET 1   
12 1 Y 1 B GLU 227 ? B GLU 227 
13 1 Y 1 B GLN 228 ? B GLN 228 
14 1 Y 1 B GLU 229 ? B GLU 229 
15 1 Y 1 B ALA 230 ? B ALA 230 
16 1 Y 1 B HIS 231 ? B HIS 231 
17 1 Y 1 B HIS 232 ? B HIS 232 
18 1 Y 1 B HIS 233 ? B HIS 233 
19 1 Y 1 B HIS 234 ? B HIS 234 
20 1 Y 1 B HIS 235 ? B HIS 235 
21 1 Y 1 B HIS 236 ? B HIS 236 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACY C    C  N N 1   
ACY O    O  N N 2   
ACY OXT  O  N N 3   
ACY CH3  C  N N 4   
ACY HXT  H  N N 5   
ACY H1   H  N N 6   
ACY H2   H  N N 7   
ACY H3   H  N N 8   
ALA N    N  N N 9   
ALA CA   C  N S 10  
ALA C    C  N N 11  
ALA O    O  N N 12  
ALA CB   C  N N 13  
ALA OXT  O  N N 14  
ALA H    H  N N 15  
ALA H2   H  N N 16  
ALA HA   H  N N 17  
ALA HB1  H  N N 18  
ALA HB2  H  N N 19  
ALA HB3  H  N N 20  
ALA HXT  H  N N 21  
ARG N    N  N N 22  
ARG CA   C  N S 23  
ARG C    C  N N 24  
ARG O    O  N N 25  
ARG CB   C  N N 26  
ARG CG   C  N N 27  
ARG CD   C  N N 28  
ARG NE   N  N N 29  
ARG CZ   C  N N 30  
ARG NH1  N  N N 31  
ARG NH2  N  N N 32  
ARG OXT  O  N N 33  
ARG H    H  N N 34  
ARG H2   H  N N 35  
ARG HA   H  N N 36  
ARG HB2  H  N N 37  
ARG HB3  H  N N 38  
ARG HG2  H  N N 39  
ARG HG3  H  N N 40  
ARG HD2  H  N N 41  
ARG HD3  H  N N 42  
ARG HE   H  N N 43  
ARG HH11 H  N N 44  
ARG HH12 H  N N 45  
ARG HH21 H  N N 46  
ARG HH22 H  N N 47  
ARG HXT  H  N N 48  
ASN N    N  N N 49  
ASN CA   C  N S 50  
ASN C    C  N N 51  
ASN O    O  N N 52  
ASN CB   C  N N 53  
ASN CG   C  N N 54  
ASN OD1  O  N N 55  
ASN ND2  N  N N 56  
ASN OXT  O  N N 57  
ASN H    H  N N 58  
ASN H2   H  N N 59  
ASN HA   H  N N 60  
ASN HB2  H  N N 61  
ASN HB3  H  N N 62  
ASN HD21 H  N N 63  
ASN HD22 H  N N 64  
ASN HXT  H  N N 65  
ASP N    N  N N 66  
ASP CA   C  N S 67  
ASP C    C  N N 68  
ASP O    O  N N 69  
ASP CB   C  N N 70  
ASP CG   C  N N 71  
ASP OD1  O  N N 72  
ASP OD2  O  N N 73  
ASP OXT  O  N N 74  
ASP H    H  N N 75  
ASP H2   H  N N 76  
ASP HA   H  N N 77  
ASP HB2  H  N N 78  
ASP HB3  H  N N 79  
ASP HD2  H  N N 80  
ASP HXT  H  N N 81  
CYS N    N  N N 82  
CYS CA   C  N R 83  
CYS C    C  N N 84  
CYS O    O  N N 85  
CYS CB   C  N N 86  
CYS SG   S  N N 87  
CYS OXT  O  N N 88  
CYS H    H  N N 89  
CYS H2   H  N N 90  
CYS HA   H  N N 91  
CYS HB2  H  N N 92  
CYS HB3  H  N N 93  
CYS HG   H  N N 94  
CYS HXT  H  N N 95  
EDO C1   C  N N 96  
EDO O1   O  N N 97  
EDO C2   C  N N 98  
EDO O2   O  N N 99  
EDO H11  H  N N 100 
EDO H12  H  N N 101 
EDO HO1  H  N N 102 
EDO H21  H  N N 103 
EDO H22  H  N N 104 
EDO HO2  H  N N 105 
GLN N    N  N N 106 
GLN CA   C  N S 107 
GLN C    C  N N 108 
GLN O    O  N N 109 
GLN CB   C  N N 110 
GLN CG   C  N N 111 
GLN CD   C  N N 112 
GLN OE1  O  N N 113 
GLN NE2  N  N N 114 
GLN OXT  O  N N 115 
GLN H    H  N N 116 
GLN H2   H  N N 117 
GLN HA   H  N N 118 
GLN HB2  H  N N 119 
GLN HB3  H  N N 120 
GLN HG2  H  N N 121 
GLN HG3  H  N N 122 
GLN HE21 H  N N 123 
GLN HE22 H  N N 124 
GLN HXT  H  N N 125 
GLU N    N  N N 126 
GLU CA   C  N S 127 
GLU C    C  N N 128 
GLU O    O  N N 129 
GLU CB   C  N N 130 
GLU CG   C  N N 131 
GLU CD   C  N N 132 
GLU OE1  O  N N 133 
GLU OE2  O  N N 134 
GLU OXT  O  N N 135 
GLU H    H  N N 136 
GLU H2   H  N N 137 
GLU HA   H  N N 138 
GLU HB2  H  N N 139 
GLU HB3  H  N N 140 
GLU HG2  H  N N 141 
GLU HG3  H  N N 142 
GLU HE2  H  N N 143 
GLU HXT  H  N N 144 
GLY N    N  N N 145 
GLY CA   C  N N 146 
GLY C    C  N N 147 
GLY O    O  N N 148 
GLY OXT  O  N N 149 
GLY H    H  N N 150 
GLY H2   H  N N 151 
GLY HA2  H  N N 152 
GLY HA3  H  N N 153 
GLY HXT  H  N N 154 
HIS N    N  N N 155 
HIS CA   C  N S 156 
HIS C    C  N N 157 
HIS O    O  N N 158 
HIS CB   C  N N 159 
HIS CG   C  Y N 160 
HIS ND1  N  Y N 161 
HIS CD2  C  Y N 162 
HIS CE1  C  Y N 163 
HIS NE2  N  Y N 164 
HIS OXT  O  N N 165 
HIS H    H  N N 166 
HIS H2   H  N N 167 
HIS HA   H  N N 168 
HIS HB2  H  N N 169 
HIS HB3  H  N N 170 
HIS HD1  H  N N 171 
HIS HD2  H  N N 172 
HIS HE1  H  N N 173 
HIS HE2  H  N N 174 
HIS HXT  H  N N 175 
HOH O    O  N N 176 
HOH H1   H  N N 177 
HOH H2   H  N N 178 
ILE N    N  N N 179 
ILE CA   C  N S 180 
ILE C    C  N N 181 
ILE O    O  N N 182 
ILE CB   C  N S 183 
ILE CG1  C  N N 184 
ILE CG2  C  N N 185 
ILE CD1  C  N N 186 
ILE OXT  O  N N 187 
ILE H    H  N N 188 
ILE H2   H  N N 189 
ILE HA   H  N N 190 
ILE HB   H  N N 191 
ILE HG12 H  N N 192 
ILE HG13 H  N N 193 
ILE HG21 H  N N 194 
ILE HG22 H  N N 195 
ILE HG23 H  N N 196 
ILE HD11 H  N N 197 
ILE HD12 H  N N 198 
ILE HD13 H  N N 199 
ILE HXT  H  N N 200 
LEU N    N  N N 201 
LEU CA   C  N S 202 
LEU C    C  N N 203 
LEU O    O  N N 204 
LEU CB   C  N N 205 
LEU CG   C  N N 206 
LEU CD1  C  N N 207 
LEU CD2  C  N N 208 
LEU OXT  O  N N 209 
LEU H    H  N N 210 
LEU H2   H  N N 211 
LEU HA   H  N N 212 
LEU HB2  H  N N 213 
LEU HB3  H  N N 214 
LEU HG   H  N N 215 
LEU HD11 H  N N 216 
LEU HD12 H  N N 217 
LEU HD13 H  N N 218 
LEU HD21 H  N N 219 
LEU HD22 H  N N 220 
LEU HD23 H  N N 221 
LEU HXT  H  N N 222 
LYS N    N  N N 223 
LYS CA   C  N S 224 
LYS C    C  N N 225 
LYS O    O  N N 226 
LYS CB   C  N N 227 
LYS CG   C  N N 228 
LYS CD   C  N N 229 
LYS CE   C  N N 230 
LYS NZ   N  N N 231 
LYS OXT  O  N N 232 
LYS H    H  N N 233 
LYS H2   H  N N 234 
LYS HA   H  N N 235 
LYS HB2  H  N N 236 
LYS HB3  H  N N 237 
LYS HG2  H  N N 238 
LYS HG3  H  N N 239 
LYS HD2  H  N N 240 
LYS HD3  H  N N 241 
LYS HE2  H  N N 242 
LYS HE3  H  N N 243 
LYS HZ1  H  N N 244 
LYS HZ2  H  N N 245 
LYS HZ3  H  N N 246 
LYS HXT  H  N N 247 
MET N    N  N N 248 
MET CA   C  N S 249 
MET C    C  N N 250 
MET O    O  N N 251 
MET CB   C  N N 252 
MET CG   C  N N 253 
MET SD   S  N N 254 
MET CE   C  N N 255 
MET OXT  O  N N 256 
MET H    H  N N 257 
MET H2   H  N N 258 
MET HA   H  N N 259 
MET HB2  H  N N 260 
MET HB3  H  N N 261 
MET HG2  H  N N 262 
MET HG3  H  N N 263 
MET HE1  H  N N 264 
MET HE2  H  N N 265 
MET HE3  H  N N 266 
MET HXT  H  N N 267 
MG  MG   MG N N 268 
PHE N    N  N N 269 
PHE CA   C  N S 270 
PHE C    C  N N 271 
PHE O    O  N N 272 
PHE CB   C  N N 273 
PHE CG   C  Y N 274 
PHE CD1  C  Y N 275 
PHE CD2  C  Y N 276 
PHE CE1  C  Y N 277 
PHE CE2  C  Y N 278 
PHE CZ   C  Y N 279 
PHE OXT  O  N N 280 
PHE H    H  N N 281 
PHE H2   H  N N 282 
PHE HA   H  N N 283 
PHE HB2  H  N N 284 
PHE HB3  H  N N 285 
PHE HD1  H  N N 286 
PHE HD2  H  N N 287 
PHE HE1  H  N N 288 
PHE HE2  H  N N 289 
PHE HZ   H  N N 290 
PHE HXT  H  N N 291 
PRO N    N  N N 292 
PRO CA   C  N S 293 
PRO C    C  N N 294 
PRO O    O  N N 295 
PRO CB   C  N N 296 
PRO CG   C  N N 297 
PRO CD   C  N N 298 
PRO OXT  O  N N 299 
PRO H    H  N N 300 
PRO HA   H  N N 301 
PRO HB2  H  N N 302 
PRO HB3  H  N N 303 
PRO HG2  H  N N 304 
PRO HG3  H  N N 305 
PRO HD2  H  N N 306 
PRO HD3  H  N N 307 
PRO HXT  H  N N 308 
SER N    N  N N 309 
SER CA   C  N S 310 
SER C    C  N N 311 
SER O    O  N N 312 
SER CB   C  N N 313 
SER OG   O  N N 314 
SER OXT  O  N N 315 
SER H    H  N N 316 
SER H2   H  N N 317 
SER HA   H  N N 318 
SER HB2  H  N N 319 
SER HB3  H  N N 320 
SER HG   H  N N 321 
SER HXT  H  N N 322 
THR N    N  N N 323 
THR CA   C  N S 324 
THR C    C  N N 325 
THR O    O  N N 326 
THR CB   C  N R 327 
THR OG1  O  N N 328 
THR CG2  C  N N 329 
THR OXT  O  N N 330 
THR H    H  N N 331 
THR H2   H  N N 332 
THR HA   H  N N 333 
THR HB   H  N N 334 
THR HG1  H  N N 335 
THR HG21 H  N N 336 
THR HG22 H  N N 337 
THR HG23 H  N N 338 
THR HXT  H  N N 339 
TRP N    N  N N 340 
TRP CA   C  N S 341 
TRP C    C  N N 342 
TRP O    O  N N 343 
TRP CB   C  N N 344 
TRP CG   C  Y N 345 
TRP CD1  C  Y N 346 
TRP CD2  C  Y N 347 
TRP NE1  N  Y N 348 
TRP CE2  C  Y N 349 
TRP CE3  C  Y N 350 
TRP CZ2  C  Y N 351 
TRP CZ3  C  Y N 352 
TRP CH2  C  Y N 353 
TRP OXT  O  N N 354 
TRP H    H  N N 355 
TRP H2   H  N N 356 
TRP HA   H  N N 357 
TRP HB2  H  N N 358 
TRP HB3  H  N N 359 
TRP HD1  H  N N 360 
TRP HE1  H  N N 361 
TRP HE3  H  N N 362 
TRP HZ2  H  N N 363 
TRP HZ3  H  N N 364 
TRP HH2  H  N N 365 
TRP HXT  H  N N 366 
TYR N    N  N N 367 
TYR CA   C  N S 368 
TYR C    C  N N 369 
TYR O    O  N N 370 
TYR CB   C  N N 371 
TYR CG   C  Y N 372 
TYR CD1  C  Y N 373 
TYR CD2  C  Y N 374 
TYR CE1  C  Y N 375 
TYR CE2  C  Y N 376 
TYR CZ   C  Y N 377 
TYR OH   O  N N 378 
TYR OXT  O  N N 379 
TYR H    H  N N 380 
TYR H2   H  N N 381 
TYR HA   H  N N 382 
TYR HB2  H  N N 383 
TYR HB3  H  N N 384 
TYR HD1  H  N N 385 
TYR HD2  H  N N 386 
TYR HE1  H  N N 387 
TYR HE2  H  N N 388 
TYR HH   H  N N 389 
TYR HXT  H  N N 390 
VAL N    N  N N 391 
VAL CA   C  N S 392 
VAL C    C  N N 393 
VAL O    O  N N 394 
VAL CB   C  N N 395 
VAL CG1  C  N N 396 
VAL CG2  C  N N 397 
VAL OXT  O  N N 398 
VAL H    H  N N 399 
VAL H2   H  N N 400 
VAL HA   H  N N 401 
VAL HB   H  N N 402 
VAL HG11 H  N N 403 
VAL HG12 H  N N 404 
VAL HG13 H  N N 405 
VAL HG21 H  N N 406 
VAL HG22 H  N N 407 
VAL HG23 H  N N 408 
VAL HXT  H  N N 409 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACY C   O    doub N N 1   
ACY C   OXT  sing N N 2   
ACY C   CH3  sing N N 3   
ACY OXT HXT  sing N N 4   
ACY CH3 H1   sing N N 5   
ACY CH3 H2   sing N N 6   
ACY CH3 H3   sing N N 7   
ALA N   CA   sing N N 8   
ALA N   H    sing N N 9   
ALA N   H2   sing N N 10  
ALA CA  C    sing N N 11  
ALA CA  CB   sing N N 12  
ALA CA  HA   sing N N 13  
ALA C   O    doub N N 14  
ALA C   OXT  sing N N 15  
ALA CB  HB1  sing N N 16  
ALA CB  HB2  sing N N 17  
ALA CB  HB3  sing N N 18  
ALA OXT HXT  sing N N 19  
ARG N   CA   sing N N 20  
ARG N   H    sing N N 21  
ARG N   H2   sing N N 22  
ARG CA  C    sing N N 23  
ARG CA  CB   sing N N 24  
ARG CA  HA   sing N N 25  
ARG C   O    doub N N 26  
ARG C   OXT  sing N N 27  
ARG CB  CG   sing N N 28  
ARG CB  HB2  sing N N 29  
ARG CB  HB3  sing N N 30  
ARG CG  CD   sing N N 31  
ARG CG  HG2  sing N N 32  
ARG CG  HG3  sing N N 33  
ARG CD  NE   sing N N 34  
ARG CD  HD2  sing N N 35  
ARG CD  HD3  sing N N 36  
ARG NE  CZ   sing N N 37  
ARG NE  HE   sing N N 38  
ARG CZ  NH1  sing N N 39  
ARG CZ  NH2  doub N N 40  
ARG NH1 HH11 sing N N 41  
ARG NH1 HH12 sing N N 42  
ARG NH2 HH21 sing N N 43  
ARG NH2 HH22 sing N N 44  
ARG OXT HXT  sing N N 45  
ASN N   CA   sing N N 46  
ASN N   H    sing N N 47  
ASN N   H2   sing N N 48  
ASN CA  C    sing N N 49  
ASN CA  CB   sing N N 50  
ASN CA  HA   sing N N 51  
ASN C   O    doub N N 52  
ASN C   OXT  sing N N 53  
ASN CB  CG   sing N N 54  
ASN CB  HB2  sing N N 55  
ASN CB  HB3  sing N N 56  
ASN CG  OD1  doub N N 57  
ASN CG  ND2  sing N N 58  
ASN ND2 HD21 sing N N 59  
ASN ND2 HD22 sing N N 60  
ASN OXT HXT  sing N N 61  
ASP N   CA   sing N N 62  
ASP N   H    sing N N 63  
ASP N   H2   sing N N 64  
ASP CA  C    sing N N 65  
ASP CA  CB   sing N N 66  
ASP CA  HA   sing N N 67  
ASP C   O    doub N N 68  
ASP C   OXT  sing N N 69  
ASP CB  CG   sing N N 70  
ASP CB  HB2  sing N N 71  
ASP CB  HB3  sing N N 72  
ASP CG  OD1  doub N N 73  
ASP CG  OD2  sing N N 74  
ASP OD2 HD2  sing N N 75  
ASP OXT HXT  sing N N 76  
CYS N   CA   sing N N 77  
CYS N   H    sing N N 78  
CYS N   H2   sing N N 79  
CYS CA  C    sing N N 80  
CYS CA  CB   sing N N 81  
CYS CA  HA   sing N N 82  
CYS C   O    doub N N 83  
CYS C   OXT  sing N N 84  
CYS CB  SG   sing N N 85  
CYS CB  HB2  sing N N 86  
CYS CB  HB3  sing N N 87  
CYS SG  HG   sing N N 88  
CYS OXT HXT  sing N N 89  
EDO C1  O1   sing N N 90  
EDO C1  C2   sing N N 91  
EDO C1  H11  sing N N 92  
EDO C1  H12  sing N N 93  
EDO O1  HO1  sing N N 94  
EDO C2  O2   sing N N 95  
EDO C2  H21  sing N N 96  
EDO C2  H22  sing N N 97  
EDO O2  HO2  sing N N 98  
GLN N   CA   sing N N 99  
GLN N   H    sing N N 100 
GLN N   H2   sing N N 101 
GLN CA  C    sing N N 102 
GLN CA  CB   sing N N 103 
GLN CA  HA   sing N N 104 
GLN C   O    doub N N 105 
GLN C   OXT  sing N N 106 
GLN CB  CG   sing N N 107 
GLN CB  HB2  sing N N 108 
GLN CB  HB3  sing N N 109 
GLN CG  CD   sing N N 110 
GLN CG  HG2  sing N N 111 
GLN CG  HG3  sing N N 112 
GLN CD  OE1  doub N N 113 
GLN CD  NE2  sing N N 114 
GLN NE2 HE21 sing N N 115 
GLN NE2 HE22 sing N N 116 
GLN OXT HXT  sing N N 117 
GLU N   CA   sing N N 118 
GLU N   H    sing N N 119 
GLU N   H2   sing N N 120 
GLU CA  C    sing N N 121 
GLU CA  CB   sing N N 122 
GLU CA  HA   sing N N 123 
GLU C   O    doub N N 124 
GLU C   OXT  sing N N 125 
GLU CB  CG   sing N N 126 
GLU CB  HB2  sing N N 127 
GLU CB  HB3  sing N N 128 
GLU CG  CD   sing N N 129 
GLU CG  HG2  sing N N 130 
GLU CG  HG3  sing N N 131 
GLU CD  OE1  doub N N 132 
GLU CD  OE2  sing N N 133 
GLU OE2 HE2  sing N N 134 
GLU OXT HXT  sing N N 135 
GLY N   CA   sing N N 136 
GLY N   H    sing N N 137 
GLY N   H2   sing N N 138 
GLY CA  C    sing N N 139 
GLY CA  HA2  sing N N 140 
GLY CA  HA3  sing N N 141 
GLY C   O    doub N N 142 
GLY C   OXT  sing N N 143 
GLY OXT HXT  sing N N 144 
HIS N   CA   sing N N 145 
HIS N   H    sing N N 146 
HIS N   H2   sing N N 147 
HIS CA  C    sing N N 148 
HIS CA  CB   sing N N 149 
HIS CA  HA   sing N N 150 
HIS C   O    doub N N 151 
HIS C   OXT  sing N N 152 
HIS CB  CG   sing N N 153 
HIS CB  HB2  sing N N 154 
HIS CB  HB3  sing N N 155 
HIS CG  ND1  sing Y N 156 
HIS CG  CD2  doub Y N 157 
HIS ND1 CE1  doub Y N 158 
HIS ND1 HD1  sing N N 159 
HIS CD2 NE2  sing Y N 160 
HIS CD2 HD2  sing N N 161 
HIS CE1 NE2  sing Y N 162 
HIS CE1 HE1  sing N N 163 
HIS NE2 HE2  sing N N 164 
HIS OXT HXT  sing N N 165 
HOH O   H1   sing N N 166 
HOH O   H2   sing N N 167 
ILE N   CA   sing N N 168 
ILE N   H    sing N N 169 
ILE N   H2   sing N N 170 
ILE CA  C    sing N N 171 
ILE CA  CB   sing N N 172 
ILE CA  HA   sing N N 173 
ILE C   O    doub N N 174 
ILE C   OXT  sing N N 175 
ILE CB  CG1  sing N N 176 
ILE CB  CG2  sing N N 177 
ILE CB  HB   sing N N 178 
ILE CG1 CD1  sing N N 179 
ILE CG1 HG12 sing N N 180 
ILE CG1 HG13 sing N N 181 
ILE CG2 HG21 sing N N 182 
ILE CG2 HG22 sing N N 183 
ILE CG2 HG23 sing N N 184 
ILE CD1 HD11 sing N N 185 
ILE CD1 HD12 sing N N 186 
ILE CD1 HD13 sing N N 187 
ILE OXT HXT  sing N N 188 
LEU N   CA   sing N N 189 
LEU N   H    sing N N 190 
LEU N   H2   sing N N 191 
LEU CA  C    sing N N 192 
LEU CA  CB   sing N N 193 
LEU CA  HA   sing N N 194 
LEU C   O    doub N N 195 
LEU C   OXT  sing N N 196 
LEU CB  CG   sing N N 197 
LEU CB  HB2  sing N N 198 
LEU CB  HB3  sing N N 199 
LEU CG  CD1  sing N N 200 
LEU CG  CD2  sing N N 201 
LEU CG  HG   sing N N 202 
LEU CD1 HD11 sing N N 203 
LEU CD1 HD12 sing N N 204 
LEU CD1 HD13 sing N N 205 
LEU CD2 HD21 sing N N 206 
LEU CD2 HD22 sing N N 207 
LEU CD2 HD23 sing N N 208 
LEU OXT HXT  sing N N 209 
LYS N   CA   sing N N 210 
LYS N   H    sing N N 211 
LYS N   H2   sing N N 212 
LYS CA  C    sing N N 213 
LYS CA  CB   sing N N 214 
LYS CA  HA   sing N N 215 
LYS C   O    doub N N 216 
LYS C   OXT  sing N N 217 
LYS CB  CG   sing N N 218 
LYS CB  HB2  sing N N 219 
LYS CB  HB3  sing N N 220 
LYS CG  CD   sing N N 221 
LYS CG  HG2  sing N N 222 
LYS CG  HG3  sing N N 223 
LYS CD  CE   sing N N 224 
LYS CD  HD2  sing N N 225 
LYS CD  HD3  sing N N 226 
LYS CE  NZ   sing N N 227 
LYS CE  HE2  sing N N 228 
LYS CE  HE3  sing N N 229 
LYS NZ  HZ1  sing N N 230 
LYS NZ  HZ2  sing N N 231 
LYS NZ  HZ3  sing N N 232 
LYS OXT HXT  sing N N 233 
MET N   CA   sing N N 234 
MET N   H    sing N N 235 
MET N   H2   sing N N 236 
MET CA  C    sing N N 237 
MET CA  CB   sing N N 238 
MET CA  HA   sing N N 239 
MET C   O    doub N N 240 
MET C   OXT  sing N N 241 
MET CB  CG   sing N N 242 
MET CB  HB2  sing N N 243 
MET CB  HB3  sing N N 244 
MET CG  SD   sing N N 245 
MET CG  HG2  sing N N 246 
MET CG  HG3  sing N N 247 
MET SD  CE   sing N N 248 
MET CE  HE1  sing N N 249 
MET CE  HE2  sing N N 250 
MET CE  HE3  sing N N 251 
MET OXT HXT  sing N N 252 
PHE N   CA   sing N N 253 
PHE N   H    sing N N 254 
PHE N   H2   sing N N 255 
PHE CA  C    sing N N 256 
PHE CA  CB   sing N N 257 
PHE CA  HA   sing N N 258 
PHE C   O    doub N N 259 
PHE C   OXT  sing N N 260 
PHE CB  CG   sing N N 261 
PHE CB  HB2  sing N N 262 
PHE CB  HB3  sing N N 263 
PHE CG  CD1  doub Y N 264 
PHE CG  CD2  sing Y N 265 
PHE CD1 CE1  sing Y N 266 
PHE CD1 HD1  sing N N 267 
PHE CD2 CE2  doub Y N 268 
PHE CD2 HD2  sing N N 269 
PHE CE1 CZ   doub Y N 270 
PHE CE1 HE1  sing N N 271 
PHE CE2 CZ   sing Y N 272 
PHE CE2 HE2  sing N N 273 
PHE CZ  HZ   sing N N 274 
PHE OXT HXT  sing N N 275 
PRO N   CA   sing N N 276 
PRO N   CD   sing N N 277 
PRO N   H    sing N N 278 
PRO CA  C    sing N N 279 
PRO CA  CB   sing N N 280 
PRO CA  HA   sing N N 281 
PRO C   O    doub N N 282 
PRO C   OXT  sing N N 283 
PRO CB  CG   sing N N 284 
PRO CB  HB2  sing N N 285 
PRO CB  HB3  sing N N 286 
PRO CG  CD   sing N N 287 
PRO CG  HG2  sing N N 288 
PRO CG  HG3  sing N N 289 
PRO CD  HD2  sing N N 290 
PRO CD  HD3  sing N N 291 
PRO OXT HXT  sing N N 292 
SER N   CA   sing N N 293 
SER N   H    sing N N 294 
SER N   H2   sing N N 295 
SER CA  C    sing N N 296 
SER CA  CB   sing N N 297 
SER CA  HA   sing N N 298 
SER C   O    doub N N 299 
SER C   OXT  sing N N 300 
SER CB  OG   sing N N 301 
SER CB  HB2  sing N N 302 
SER CB  HB3  sing N N 303 
SER OG  HG   sing N N 304 
SER OXT HXT  sing N N 305 
THR N   CA   sing N N 306 
THR N   H    sing N N 307 
THR N   H2   sing N N 308 
THR CA  C    sing N N 309 
THR CA  CB   sing N N 310 
THR CA  HA   sing N N 311 
THR C   O    doub N N 312 
THR C   OXT  sing N N 313 
THR CB  OG1  sing N N 314 
THR CB  CG2  sing N N 315 
THR CB  HB   sing N N 316 
THR OG1 HG1  sing N N 317 
THR CG2 HG21 sing N N 318 
THR CG2 HG22 sing N N 319 
THR CG2 HG23 sing N N 320 
THR OXT HXT  sing N N 321 
TRP N   CA   sing N N 322 
TRP N   H    sing N N 323 
TRP N   H2   sing N N 324 
TRP CA  C    sing N N 325 
TRP CA  CB   sing N N 326 
TRP CA  HA   sing N N 327 
TRP C   O    doub N N 328 
TRP C   OXT  sing N N 329 
TRP CB  CG   sing N N 330 
TRP CB  HB2  sing N N 331 
TRP CB  HB3  sing N N 332 
TRP CG  CD1  doub Y N 333 
TRP CG  CD2  sing Y N 334 
TRP CD1 NE1  sing Y N 335 
TRP CD1 HD1  sing N N 336 
TRP CD2 CE2  doub Y N 337 
TRP CD2 CE3  sing Y N 338 
TRP NE1 CE2  sing Y N 339 
TRP NE1 HE1  sing N N 340 
TRP CE2 CZ2  sing Y N 341 
TRP CE3 CZ3  doub Y N 342 
TRP CE3 HE3  sing N N 343 
TRP CZ2 CH2  doub Y N 344 
TRP CZ2 HZ2  sing N N 345 
TRP CZ3 CH2  sing Y N 346 
TRP CZ3 HZ3  sing N N 347 
TRP CH2 HH2  sing N N 348 
TRP OXT HXT  sing N N 349 
TYR N   CA   sing N N 350 
TYR N   H    sing N N 351 
TYR N   H2   sing N N 352 
TYR CA  C    sing N N 353 
TYR CA  CB   sing N N 354 
TYR CA  HA   sing N N 355 
TYR C   O    doub N N 356 
TYR C   OXT  sing N N 357 
TYR CB  CG   sing N N 358 
TYR CB  HB2  sing N N 359 
TYR CB  HB3  sing N N 360 
TYR CG  CD1  doub Y N 361 
TYR CG  CD2  sing Y N 362 
TYR CD1 CE1  sing Y N 363 
TYR CD1 HD1  sing N N 364 
TYR CD2 CE2  doub Y N 365 
TYR CD2 HD2  sing N N 366 
TYR CE1 CZ   doub Y N 367 
TYR CE1 HE1  sing N N 368 
TYR CE2 CZ   sing Y N 369 
TYR CE2 HE2  sing N N 370 
TYR CZ  OH   sing N N 371 
TYR OH  HH   sing N N 372 
TYR OXT HXT  sing N N 373 
VAL N   CA   sing N N 374 
VAL N   H    sing N N 375 
VAL N   H2   sing N N 376 
VAL CA  C    sing N N 377 
VAL CA  CB   sing N N 378 
VAL CA  HA   sing N N 379 
VAL C   O    doub N N 380 
VAL C   OXT  sing N N 381 
VAL CB  CG1  sing N N 382 
VAL CB  CG2  sing N N 383 
VAL CB  HB   sing N N 384 
VAL CG1 HG11 sing N N 385 
VAL CG1 HG12 sing N N 386 
VAL CG1 HG13 sing N N 387 
VAL CG2 HG21 sing N N 388 
VAL CG2 HG22 sing N N 389 
VAL CG2 HG23 sing N N 390 
VAL OXT HXT  sing N N 391 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8JMS 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.crystal_system   monoclinic 
_space_group.IT_number        4 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DQ0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022474 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000239 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013327 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011552 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG  ? ? 9.41153 2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366 3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . PRO A 1 2   ? 14.67396  1.06863   55.48599  1.000 39.18450 ?  2   PRO A N   1 
ATOM   2    C  CA  . PRO A 1 2   ? 14.08045  0.67061   54.20840  1.000 39.79308 ?  2   PRO A CA  1 
ATOM   3    C  C   . PRO A 1 2   ? 13.50834  1.82829   53.40408  1.000 26.33657 ?  2   PRO A C   1 
ATOM   4    O  O   . PRO A 1 2   ? 13.86495  2.98010   53.62349  1.000 37.93189 ?  2   PRO A O   1 
ATOM   5    C  CB  . PRO A 1 2   ? 12.98850  -0.30206  54.63946  1.000 38.53353 ?  2   PRO A CB  1 
ATOM   6    C  CG  . PRO A 1 2   ? 13.57300  -0.95688  55.91248  1.000 44.45189 ?  2   PRO A CG  1 
ATOM   7    C  CD  . PRO A 1 2   ? 14.72663  -0.07789  56.40608  1.000 47.91226 ?  2   PRO A CD  1 
ATOM   8    N  N   . LEU A 1 3   ? 12.64581  1.51019   52.44516  1.000 26.47952 ?  3   LEU A N   1 
ATOM   9    C  CA  . LEU A 1 3   ? 12.19597  2.52512   51.50098  1.000 26.58204 ?  3   LEU A CA  1 
ATOM   10   C  C   . LEU A 1 3   ? 11.24719  3.51722   52.15867  1.000 35.71135 ?  3   LEU A C   1 
ATOM   11   O  O   . LEU A 1 3   ? 11.43451  4.73777   52.07027  1.000 33.77940 ?  3   LEU A O   1 
ATOM   12   C  CB  . LEU A 1 3   ? 11.53870  1.85706   50.29730  1.000 26.52075 ?  3   LEU A CB  1 
ATOM   13   C  CG  . LEU A 1 3   ? 12.49571  1.15768   49.34494  1.000 21.53051 ?  3   LEU A CG  1 
ATOM   14   C  CD1 . LEU A 1 3   ? 11.72403  0.53302   48.20135  1.000 16.63569 ?  3   LEU A CD1 1 
ATOM   15   C  CD2 . LEU A 1 3   ? 13.50851  2.15257   48.81610  1.000 25.73225 ?  3   LEU A CD2 1 
ATOM   16   N  N   . GLY A 1 4   ? 10.22505  3.02041   52.81983  1.000 34.73574 ?  4   GLY A N   1 
ATOM   17   C  CA  . GLY A 1 4   ? 9.24422   3.95253   53.32752  1.000 53.85380 ?  4   GLY A CA  1 
ATOM   18   C  C   . GLY A 1 4   ? 7.98786   3.98278   52.47275  1.000 43.64317 ?  4   GLY A C   1 
ATOM   19   O  O   . GLY A 1 4   ? 7.91730   3.40094   51.38651  1.000 37.93000 ?  4   GLY A O   1 
ATOM   20   N  N   . THR A 1 5   ? 6.99731   4.72480   52.96944  1.000 43.34424 ?  5   THR A N   1 
ATOM   21   C  CA  . THR A 1 5   ? 5.60904   4.49667   52.59713  1.000 41.53259 ?  5   THR A CA  1 
ATOM   22   C  C   . THR A 1 5   ? 5.31655   4.77939   51.13584  1.000 28.73679 ?  5   THR A C   1 
ATOM   23   O  O   . THR A 1 5   ? 4.42433   4.16242   50.56187  1.000 30.51380 ?  5   THR A O   1 
ATOM   24   C  CB  . THR A 1 5   ? 4.68228   5.32375   53.48735  1.000 50.82052 ?  5   THR A CB  1 
ATOM   25   O  OG1 . THR A 1 5   ? 3.34334   4.83908   53.34220  1.000 58.42372 ?  5   THR A OG1 1 
ATOM   26   C  CG2 . THR A 1 5   ? 4.73077   6.80691   53.10834  1.000 42.00380 ?  5   THR A CG2 1 
ATOM   27   N  N   . GLU A 1 6   ? 6.03818   5.69911   50.51615  1.000 30.51676 ?  6   GLU A N   1 
ATOM   28   C  CA  . GLU A 1 6   ? 5.78401   5.99464   49.11683  1.000 30.22285 ?  6   GLU A CA  1 
ATOM   29   C  C   . GLU A 1 6   ? 6.52737   5.05406   48.17612  1.000 23.21529 ?  6   GLU A C   1 
ATOM   30   O  O   . GLU A 1 6   ? 6.32657   5.12382   46.96057  1.000 18.04946 ?  6   GLU A O   1 
ATOM   31   C  CB  . GLU A 1 6   ? 6.13492   7.45255   48.81824  1.000 34.01779 ?  6   GLU A CB  1 
ATOM   32   C  CG  . GLU A 1 6   ? 5.29761   8.46363   49.60654  1.000 43.34182 ?  6   GLU A CG  1 
ATOM   33   C  CD  . GLU A 1 6   ? 4.12871   8.98715   48.79424  1.000 56.38614 ?  6   GLU A CD  1 
ATOM   34   O  OE1 . GLU A 1 6   ? 3.05309   8.33023   48.79636  1.000 52.93161 ?  6   GLU A OE1 1 
ATOM   35   O  OE2 . GLU A 1 6   ? 4.30861   10.04283  48.13548  1.000 50.47511 -1 6   GLU A OE2 1 
ATOM   36   N  N   . GLY A 1 7   ? 7.34737   4.15721   48.71139  1.000 19.12745 ?  7   GLY A N   1 
ATOM   37   C  CA  . GLY A 1 7   ? 7.99080   3.15401   47.89657  1.000 21.38914 ?  7   GLY A CA  1 
ATOM   38   C  C   . GLY A 1 7   ? 9.24881   3.60344   47.18907  1.000 17.67872 ?  7   GLY A C   1 
ATOM   39   O  O   . GLY A 1 7   ? 9.68744   2.92261   46.25053  1.000 15.73515 ?  7   GLY A O   1 
ATOM   40   N  N   . PHE A 1 8   ? 9.83654   4.72593   47.59771  1.000 15.35774 ?  8   PHE A N   1 
ATOM   41   C  CA  . PHE A 1 8   ? 11.10023  5.17207   47.03287  1.000 14.51779 ?  8   PHE A CA  1 
ATOM   42   C  C   . PHE A 1 8   ? 11.86065  5.98366   48.06777  1.000 15.66028 ?  8   PHE A C   1 
ATOM   43   O  O   . PHE A 1 8   ? 11.28634  6.52439   49.01576  1.000 9.08425  ?  8   PHE A O   1 
ATOM   44   C  CB  . PHE A 1 8   ? 10.89020  6.00713   45.75766  1.000 7.96877  ?  8   PHE A CB  1 
ATOM   45   C  CG  . PHE A 1 8   ? 10.48951  7.42430   46.02225  1.000 12.07923 ?  8   PHE A CG  1 
ATOM   46   C  CD1 . PHE A 1 8   ? 9.15922   7.75652   46.25099  1.000 15.91253 ?  8   PHE A CD1 1 
ATOM   47   C  CD2 . PHE A 1 8   ? 11.44553  8.43208   46.03671  1.000 12.35054 ?  8   PHE A CD2 1 
ATOM   48   C  CE1 . PHE A 1 8   ? 8.79303   9.07069   46.49544  1.000 13.46773 ?  8   PHE A CE1 1 
ATOM   49   C  CE2 . PHE A 1 8   ? 11.09109  9.74600   46.28325  1.000 14.60597 ?  8   PHE A CE2 1 
ATOM   50   C  CZ  . PHE A 1 8   ? 9.75602   10.06404  46.50887  1.000 15.08870 ?  8   PHE A CZ  1 
ATOM   51   N  N   . THR A 1 9   ? 13.17067  6.05895   47.87377  1.000 10.62313 ?  9   THR A N   1 
ATOM   52   C  CA  A THR A 1 9   ? 14.03883  6.91252   48.67212  0.316 11.74455 ?  9   THR A CA  1 
ATOM   53   C  CA  B THR A 1 9   ? 13.98661  6.97201   48.64350  0.684 11.89063 ?  9   THR A CA  1 
ATOM   54   C  C   . THR A 1 9   ? 15.14296  7.44224   47.76616  1.000 13.79549 ?  9   THR A C   1 
ATOM   55   O  O   . THR A 1 9   ? 15.60181  6.73380   46.86382  1.000 11.32581 ?  9   THR A O   1 
ATOM   56   C  CB  A THR A 1 9   ? 14.65185  6.15131   49.86378  0.316 14.29142 ?  9   THR A CB  1 
ATOM   57   C  CB  B THR A 1 9   ? 14.48327  6.33756   49.95672  0.684 14.35296 ?  9   THR A CB  1 
ATOM   58   O  OG1 A THR A 1 9   ? 13.61365  5.51992   50.62595  0.316 14.01196 ?  9   THR A OG1 1 
ATOM   59   O  OG1 B THR A 1 9   ? 15.17438  7.32483   50.71760  0.684 14.19607 ?  9   THR A OG1 1 
ATOM   60   C  CG2 A THR A 1 9   ? 15.42285  7.09249   50.76573  0.316 14.06384 ?  9   THR A CG2 1 
ATOM   61   C  CG2 B THR A 1 9   ? 15.41705  5.17217   49.70595  0.684 14.15119 ?  9   THR A CG2 1 
ATOM   62   N  N   . VAL A 1 10  ? 15.55728  8.68479   47.99145  1.000 8.64598  ?  10  VAL A N   1 
ATOM   63   C  CA  . VAL A 1 10  ? 16.70443  9.27204   47.30303  1.000 10.35106 ?  10  VAL A CA  1 
ATOM   64   C  C   . VAL A 1 10  ? 17.84966  9.33589   48.30281  1.000 13.63414 ?  10  VAL A C   1 
ATOM   65   O  O   . VAL A 1 10  ? 17.66674  9.83611   49.41162  1.000 8.84273  ?  10  VAL A O   1 
ATOM   66   C  CB  . VAL A 1 10  ? 16.38853  10.67358  46.74786  1.000 11.17204 ?  10  VAL A CB  1 
ATOM   67   C  CG1 . VAL A 1 10  ? 17.65045  11.28979  46.11551  1.000 7.54566  ?  10  VAL A CG1 1 
ATOM   68   C  CG2 . VAL A 1 10  ? 15.26112  10.59054  45.74329  1.000 8.84708  ?  10  VAL A CG2 1 
ATOM   69   N  N   . ILE A 1 11  ? 19.02205  8.82669   47.92085  1.000 9.18426  ?  11  ILE A N   1 
ATOM   70   C  CA  . ILE A 1 11  ? 20.17216  8.77591   48.81554  1.000 10.82671 ?  11  ILE A CA  1 
ATOM   71   C  C   . ILE A 1 11  ? 21.37199  9.44976   48.16654  1.000 10.33359 ?  11  ILE A C   1 
ATOM   72   O  O   . ILE A 1 11  ? 21.47540  9.52718   46.93939  1.000 9.68470  ?  11  ILE A O   1 
ATOM   73   C  CB  . ILE A 1 11  ? 20.54731  7.32635   49.18488  1.000 14.59308 ?  11  ILE A CB  1 
ATOM   74   C  CG1 . ILE A 1 11  ? 21.00900  6.56395   47.93095  1.000 10.65907 ?  11  ILE A CG1 1 
ATOM   75   C  CG2 . ILE A 1 11  ? 19.39298  6.62487   49.83935  1.000 17.06645 ?  11  ILE A CG2 1 
ATOM   76   C  CD1 . ILE A 1 11  ? 21.59326  5.20945   48.25541  1.000 13.52773 ?  11  ILE A CD1 1 
ATOM   77   N  N   . ASP A 1 12  ? 22.27607  9.94936   49.00567  1.000 12.89097 ?  12  ASP A N   1 
ATOM   78   C  CA  . ASP A 1 12  ? 23.59446  10.40237  48.56933  1.000 16.20053 ?  12  ASP A CA  1 
ATOM   79   C  C   . ASP A 1 12  ? 24.55605  9.22476   48.53241  1.000 18.56023 ?  12  ASP A C   1 
ATOM   80   O  O   . ASP A 1 12  ? 24.45626  8.30561   49.34454  1.000 21.71500 ?  12  ASP A O   1 
ATOM   81   C  CB  . ASP A 1 12  ? 24.15383  11.46514  49.51104  1.000 19.05674 ?  12  ASP A CB  1 
ATOM   82   C  CG  . ASP A 1 12  ? 23.39140  12.75526  49.44437  1.000 18.48041 ?  12  ASP A CG  1 
ATOM   83   O  OD1 . ASP A 1 12  ? 22.99627  13.14591  48.32805  1.000 23.35727 -1 12  ASP A OD1 1 
ATOM   84   O  OD2 . ASP A 1 12  ? 23.18266  13.37328  50.51013  1.000 24.29925 ?  12  ASP A OD2 1 
ATOM   85   N  N   . LEU A 1 13  ? 25.46580  9.24600   47.59215  1.000 13.01330 ?  13  LEU A N   1 
ATOM   86   C  CA  . LEU A 1 13  ? 26.39044  8.13007   47.47862  1.000 15.06571 ?  13  LEU A CA  1 
ATOM   87   C  C   . LEU A 1 13  ? 27.73551  8.52568   48.04397  1.000 18.13379 ?  13  LEU A C   1 
ATOM   88   O  O   . LEU A 1 13  ? 28.09025  9.70375   48.03741  1.000 13.94300 ?  13  LEU A O   1 
ATOM   89   C  CB  . LEU A 1 13  ? 26.56577  7.73742   46.01041  1.000 17.93166 ?  13  LEU A CB  1 
ATOM   90   C  CG  . LEU A 1 13  ? 25.27317  7.32617   45.30129  1.000 16.69873 ?  13  LEU A CG  1 
ATOM   91   C  CD1 . LEU A 1 13  ? 25.50724  7.27879   43.81404  1.000 14.77240 ?  13  LEU A CD1 1 
ATOM   92   C  CD2 . LEU A 1 13  ? 24.83592  5.97772   45.82801  1.000 19.46004 ?  13  LEU A CD2 1 
ATOM   93   N  N   . PRO A 1 14  ? 28.52426  7.57662   48.52481  1.000 21.05695 ?  14  PRO A N   1 
ATOM   94   C  CA  . PRO A 1 14  ? 29.89101  7.89989   48.93640  1.000 24.55641 ?  14  PRO A CA  1 
ATOM   95   C  C   . PRO A 1 14  ? 30.76928  8.13073   47.71695  1.000 22.41792 ?  14  PRO A C   1 
ATOM   96   O  O   . PRO A 1 14  ? 30.38401  7.85907   46.58114  1.000 19.11379 ?  14  PRO A O   1 
ATOM   97   C  CB  . PRO A 1 14  ? 30.33078  6.65457   49.71178  1.000 30.92910 ?  14  PRO A CB  1 
ATOM   98   C  CG  . PRO A 1 14  ? 29.55212  5.55541   49.10249  1.000 30.20205 ?  14  PRO A CG  1 
ATOM   99   C  CD  . PRO A 1 14  ? 28.22606  6.14760   48.68553  1.000 19.58080 ?  14  PRO A CD  1 
ATOM   100  N  N   . GLU A 1 15  ? 31.96549  8.65801   47.98496  1.000 27.06979 ?  15  GLU A N   1 
ATOM   101  C  CA  . GLU A 1 15  ? 33.01577  8.76990   46.98030  1.000 20.65147 ?  15  GLU A CA  1 
ATOM   102  C  C   . GLU A 1 15  ? 33.28133  7.40997   46.34205  1.000 19.96094 ?  15  GLU A C   1 
ATOM   103  O  O   . GLU A 1 15  ? 33.16768  6.36435   46.98956  1.000 14.26683 ?  15  GLU A O   1 
ATOM   104  C  CB  . GLU A 1 15  ? 34.29780  9.31733   47.63977  1.000 30.33111 ?  15  GLU A CB  1 
ATOM   105  C  CG  . GLU A 1 15  ? 35.29149  10.03705  46.70740  1.000 43.46984 ?  15  GLU A CG  1 
ATOM   106  C  CD  . GLU A 1 15  ? 36.40142  10.79974  47.46782  1.000 69.06143 ?  15  GLU A CD  1 
ATOM   107  O  OE1 . GLU A 1 15  ? 37.02522  10.22476  48.39074  1.000 62.78929 ?  15  GLU A OE1 1 
ATOM   108  O  OE2 . GLU A 1 15  ? 36.64758  11.98436  47.14453  1.000 71.17801 -1 15  GLU A OE2 1 
ATOM   109  N  N   . VAL A 1 16  ? 33.60401  7.42814   45.05321  1.000 16.45932 ?  16  VAL A N   1 
ATOM   110  C  CA  . VAL A 1 16  ? 33.84974  6.21628   44.29115  1.000 18.46714 ?  16  VAL A CA  1 
ATOM   111  C  C   . VAL A 1 16  ? 35.33244  6.16378   43.92044  1.000 17.01343 ?  16  VAL A C   1 
ATOM   112  O  O   . VAL A 1 16  ? 36.01940  7.18748   43.85375  1.000 14.01587 ?  16  VAL A O   1 
ATOM   113  C  CB  . VAL A 1 16  ? 32.94787  6.15113   43.04016  1.000 17.70680 ?  16  VAL A CB  1 
ATOM   114  C  CG1 . VAL A 1 16  ? 31.48347  6.31875   43.44578  1.000 20.94048 ?  16  VAL A CG1 1 
ATOM   115  C  CG2 . VAL A 1 16  ? 33.31295  7.24971   42.07067  1.000 15.61528 ?  16  VAL A CG2 1 
ATOM   116  N  N   . ALA A 1 17  ? 35.82590  4.94588   43.69623  1.000 18.82451 ?  17  ALA A N   1 
ATOM   117  C  CA  . ALA A 1 17  ? 37.22086  4.74249   43.32797  1.000 15.30250 ?  17  ALA A CA  1 
ATOM   118  C  C   . ALA A 1 17  ? 37.54875  5.54621   42.07353  1.000 16.02181 ?  17  ALA A C   1 
ATOM   119  O  O   . ALA A 1 17  ? 36.67293  5.77753   41.23571  1.000 14.76062 ?  17  ALA A O   1 
ATOM   120  C  CB  . ALA A 1 17  ? 37.49003  3.25579   43.07496  1.000 19.29161 ?  17  ALA A CB  1 
ATOM   121  N  N   . PRO A 1 18  ? 38.80438  5.97556   41.90551  1.000 18.21882 ?  18  PRO A N   1 
ATOM   122  C  CA  . PRO A 1 18  ? 39.12317  6.83944   40.76008  1.000 11.04807 ?  18  PRO A CA  1 
ATOM   123  C  C   . PRO A 1 18  ? 39.00966  6.15267   39.41460  1.000 10.79768 ?  18  PRO A C   1 
ATOM   124  O  O   . PRO A 1 18  ? 39.09656  6.85653   38.40743  1.000 10.91783 ?  18  PRO A O   1 
ATOM   125  C  CB  . PRO A 1 18  ? 40.57015  7.30234   41.04150  1.000 15.83803 ?  18  PRO A CB  1 
ATOM   126  C  CG  . PRO A 1 18  ? 41.13184  6.32674   41.97456  1.000 16.88776 ?  18  PRO A CG  1 
ATOM   127  C  CD  . PRO A 1 18  ? 39.97377  5.77221   42.78300  1.000 21.45181 ?  18  PRO A CD  1 
ATOM   128  N  N   . ASP A 1 19  ? 38.79986  4.82644   39.34829  1.000 10.21542 ?  19  ASP A N   1 
ATOM   129  C  CA  . ASP A 1 19  ? 38.62670  4.20419   38.04227  1.000 10.52869 ?  19  ASP A CA  1 
ATOM   130  C  C   . ASP A 1 19  ? 37.18620  4.21372   37.53602  1.000 11.69725 ?  19  ASP A C   1 
ATOM   131  O  O   . ASP A 1 19  ? 36.96113  3.93488   36.35079  1.000 8.73033  ?  19  ASP A O   1 
ATOM   132  C  CB  . ASP A 1 19  ? 39.13607  2.75695   38.03987  1.000 15.13699 ?  19  ASP A CB  1 
ATOM   133  C  CG  . ASP A 1 19  ? 38.40128  1.86492   39.01619  1.000 16.43384 ?  19  ASP A CG  1 
ATOM   134  O  OD1 . ASP A 1 19  ? 37.74465  2.38637   39.92828  1.000 18.03837 ?  19  ASP A OD1 1 
ATOM   135  O  OD2 . ASP A 1 19  ? 38.50957  0.62769   38.88644  1.000 19.58263 -1 19  ASP A OD2 1 
ATOM   136  N  N   . ILE A 1 20  ? 36.21201  4.56057   38.36918  1.000 12.36003 ?  20  ILE A N   1 
ATOM   137  C  CA  . ILE A 1 20  ? 34.80989  4.39055   37.96571  1.000 9.92359  ?  20  ILE A CA  1 
ATOM   138  C  C   . ILE A 1 20  ? 34.41269  5.40145   36.89331  1.000 9.63363  ?  20  ILE A C   1 
ATOM   139  O  O   . ILE A 1 20  ? 33.95123  5.02801   35.80889  1.000 12.72353 ?  20  ILE A O   1 
ATOM   140  C  CB  . ILE A 1 20  ? 33.88966  4.45553   39.19745  1.000 13.42523 ?  20  ILE A CB  1 
ATOM   141  C  CG1 . ILE A 1 20  ? 34.25878  3.28227   40.11926  1.000 16.13318 ?  20  ILE A CG1 1 
ATOM   142  C  CG2 . ILE A 1 20  ? 32.42579  4.45977   38.76111  1.000 11.71820 ?  20  ILE A CG2 1 
ATOM   143  C  CD1 . ILE A 1 20  ? 33.17824  2.74406   40.97232  1.000 19.61380 ?  20  ILE A CD1 1 
ATOM   144  N  N   . LEU A 1 21  ? 34.59349  6.68593   37.16212  1.000 7.28108  ?  21  LEU A N   1 
ATOM   145  C  CA  . LEU A 1 21  ? 34.18357  7.68744   36.17691  1.000 7.39950  ?  21  LEU A CA  1 
ATOM   146  C  C   . LEU A 1 21  ? 34.88653  7.54918   34.83807  1.000 8.22235  ?  21  LEU A C   1 
ATOM   147  O  O   . LEU A 1 21  ? 34.20500  7.65473   33.80000  1.000 9.67661  ?  21  LEU A O   1 
ATOM   148  C  CB  . LEU A 1 21  ? 34.37603  9.09224   36.75617  1.000 9.96689  ?  21  LEU A CB  1 
ATOM   149  C  CG  . LEU A 1 21  ? 33.10444  9.73507   37.32628  1.000 16.02314 ?  21  LEU A CG  1 
ATOM   150  C  CD1 . LEU A 1 21  ? 32.51651  8.90266   38.44923  1.000 13.59988 ?  21  LEU A CD1 1 
ATOM   151  C  CD2 . LEU A 1 21  ? 33.40252  11.14359  37.80277  1.000 14.00815 ?  21  LEU A CD2 1 
ATOM   152  N  N   . PRO A 1 22  ? 36.20433  7.32865   34.75689  1.000 9.48553  ?  22  PRO A N   1 
ATOM   153  C  CA  . PRO A 1 22  ? 36.82726  7.18515   33.43455  1.000 12.91748 ?  22  PRO A CA  1 
ATOM   154  C  C   . PRO A 1 22  ? 36.34583  5.96525   32.67470  1.000 9.27156  ?  22  PRO A C   1 
ATOM   155  O  O   . PRO A 1 22  ? 36.35803  5.96002   31.43638  1.000 10.10429 ?  22  PRO A O   1 
ATOM   156  C  CB  . PRO A 1 22  ? 38.32719  7.07557   33.76147  1.000 11.51160 ?  22  PRO A CB  1 
ATOM   157  C  CG  . PRO A 1 22  ? 38.47273  7.65728   35.08753  1.000 14.99883 ?  22  PRO A CG  1 
ATOM   158  C  CD  . PRO A 1 22  ? 37.21784  7.36458   35.82841  1.000 15.04674 ?  22  PRO A CD  1 
ATOM   159  N  N   . SER A 1 23  ? 35.93236  4.91586   33.37740  1.000 10.00610 ?  23  SER A N   1 
ATOM   160  C  CA  . SER A 1 23  ? 35.53940  3.69246   32.68735  1.000 11.93772 ?  23  SER A CA  1 
ATOM   161  C  C   . SER A 1 23  ? 34.34920  3.91301   31.76584  1.000 9.53192  ?  23  SER A C   1 
ATOM   162  O  O   . SER A 1 23  ? 34.14343  3.12439   30.83298  1.000 9.92273  ?  23  SER A O   1 
ATOM   163  C  CB  . SER A 1 23  ? 35.21573  2.59774   33.70568  1.000 10.58634 ?  23  SER A CB  1 
ATOM   164  O  OG  . SER A 1 23  ? 33.95611  2.83309   34.32854  1.000 10.57900 ?  23  SER A OG  1 
ATOM   165  N  N   . TYR A 1 24  ? 33.57997  4.98825   31.98182  1.000 11.60814 ?  24  TYR A N   1 
ATOM   166  C  CA  . TYR A 1 24  ? 32.45448  5.26725   31.09579  1.000 13.49030 ?  24  TYR A CA  1 
ATOM   167  C  C   . TYR A 1 24  ? 32.91149  5.61919   29.68078  1.000 14.14785 ?  24  TYR A C   1 
ATOM   168  O  O   . TYR A 1 24  ? 32.19333  5.33463   28.71080  1.000 10.98369 ?  24  TYR A O   1 
ATOM   169  C  CB  . TYR A 1 24  ? 31.59173  6.37643   31.69056  1.000 12.51302 ?  24  TYR A CB  1 
ATOM   170  C  CG  . TYR A 1 24  ? 30.66541  5.86744   32.78261  1.000 13.42707 ?  24  TYR A CG  1 
ATOM   171  C  CD1 . TYR A 1 24  ? 31.06404  5.87379   34.11220  1.000 8.90338  ?  24  TYR A CD1 1 
ATOM   172  C  CD2 . TYR A 1 24  ? 29.40084  5.35637   32.46871  1.000 9.78706  ?  24  TYR A CD2 1 
ATOM   173  C  CE1 . TYR A 1 24  ? 30.23157  5.40903   35.11668  1.000 14.41276 ?  24  TYR A CE1 1 
ATOM   174  C  CE2 . TYR A 1 24  ? 28.54108  4.89660   33.46628  1.000 7.28171  ?  24  TYR A CE2 1 
ATOM   175  C  CZ  . TYR A 1 24  ? 28.97335  4.91668   34.78698  1.000 9.82358  ?  24  TYR A CZ  1 
ATOM   176  O  OH  . TYR A 1 24  ? 28.16330  4.46825   35.79786  1.000 10.43746 ?  24  TYR A OH  1 
ATOM   177  N  N   . ASP A 1 25  ? 34.11347  6.18883   29.53371  1.000 12.64762 ?  25  ASP A N   1 
ATOM   178  C  CA  . ASP A 1 25  ? 34.63494  6.44532   28.19177  1.000 12.56470 ?  25  ASP A CA  1 
ATOM   179  C  C   . ASP A 1 25  ? 34.95442  5.17012   27.43494  1.000 11.54863 ?  25  ASP A C   1 
ATOM   180  O  O   . ASP A 1 25  ? 35.18567  5.23116   26.22513  1.000 13.87467 ?  25  ASP A O   1 
ATOM   181  C  CB  . ASP A 1 25  ? 35.89696  7.30827   28.24151  1.000 16.36166 ?  25  ASP A CB  1 
ATOM   182  C  CG  . ASP A 1 25  ? 35.62924  8.67508   28.78855  1.000 18.89283 ?  25  ASP A CG  1 
ATOM   183  O  OD1 . ASP A 1 25  ? 34.55152  9.23568   28.47099  1.000 18.90335 ?  25  ASP A OD1 1 
ATOM   184  O  OD2 . ASP A 1 25  ? 36.47776  9.18024   29.55312  1.000 21.29929 -1 25  ASP A OD2 1 
ATOM   185  N  N   . ARG A 1 26  ? 34.99715  4.01949   28.10537  1.000 12.60288 ?  26  ARG A N   1 
ATOM   186  C  CA  . ARG A 1 26  ? 35.33939  2.76758   27.43871  1.000 13.00355 ?  26  ARG A CA  1 
ATOM   187  C  C   . ARG A 1 26  ? 34.13822  1.83390   27.32856  1.000 14.28986 ?  26  ARG A C   1 
ATOM   188  O  O   . ARG A 1 26  ? 34.31378  0.62376   27.14424  1.000 14.39169 ?  26  ARG A O   1 
ATOM   189  C  CB  . ARG A 1 26  ? 36.49612  2.06249   28.16089  1.000 11.43964 ?  26  ARG A CB  1 
ATOM   190  C  CG  . ARG A 1 26  ? 37.75791  2.90525   28.33849  1.000 18.02991 ?  26  ARG A CG  1 
ATOM   191  C  CD  . ARG A 1 26  ? 38.92801  2.04782   28.82892  1.000 15.14509 ?  26  ARG A CD  1 
ATOM   192  N  NE  . ARG A 1 26  ? 38.64905  1.38610   30.10281  1.000 18.76736 ?  26  ARG A NE  1 
ATOM   193  C  CZ  . ARG A 1 26  ? 38.74144  1.97409   31.28963  1.000 19.69724 ?  26  ARG A CZ  1 
ATOM   194  N  NH1 . ARG A 1 26  ? 39.07641  3.25197   31.40547  1.000 18.14848 ?  26  ARG A NH1 1 
ATOM   195  N  NH2 . ARG A 1 26  ? 38.47063  1.27029   32.38620  1.000 24.41792 ?  26  ARG A NH2 1 
ATOM   196  N  N   . CYS A 1 27  ? 32.92340  2.36687   27.46784  1.000 12.00953 ?  27  CYS A N   1 
ATOM   197  C  CA  . CYS A 1 27  ? 31.74361  1.53987   27.20020  1.000 10.73213 ?  27  CYS A CA  1 
ATOM   198  C  C   . CYS A 1 27  ? 31.38647  1.62799   25.72703  1.000 12.45921 ?  27  CYS A C   1 
ATOM   199  O  O   . CYS A 1 27  ? 31.19250  2.73751   25.20944  1.000 10.05590 ?  27  CYS A O   1 
ATOM   200  C  CB  . CYS A 1 27  ? 30.55828  1.98619   28.03806  1.000 9.58990  ?  27  CYS A CB  1 
ATOM   201  S  SG  . CYS A 1 27  ? 30.80234  1.72887   29.80231  1.000 13.02678 ?  27  CYS A SG  1 
ATOM   202  N  N   . PRO A 1 28  ? 31.27680  0.49924   25.03867  1.000 11.48253 ?  28  PRO A N   1 
ATOM   203  C  CA  . PRO A 1 28  ? 30.92169  0.51602   23.62094  1.000 10.67419 ?  28  PRO A CA  1 
ATOM   204  C  C   . PRO A 1 28  ? 29.44719  0.85695   23.44314  1.000 17.15063 ?  28  PRO A C   1 
ATOM   205  O  O   . PRO A 1 28  ? 28.66743  0.87122   24.39160  1.000 13.07555 ?  28  PRO A O   1 
ATOM   206  C  CB  . PRO A 1 28  ? 31.20591  -0.91800  23.17127  1.000 14.70397 ?  28  PRO A CB  1 
ATOM   207  C  CG  . PRO A 1 28  ? 30.92557  -1.72989  24.36893  1.000 16.72633 ?  28  PRO A CG  1 
ATOM   208  C  CD  . PRO A 1 28  ? 31.30965  -0.87049  25.57941  1.000 14.45546 ?  28  PRO A CD  1 
ATOM   209  N  N   . VAL A 1 29  ? 29.08038  1.13476   22.19339  1.000 13.88575 ?  29  VAL A N   1 
ATOM   210  C  CA  . VAL A 1 29  ? 27.71603  1.54955   21.89859  1.000 12.84315 ?  29  VAL A CA  1 
ATOM   211  C  C   . VAL A 1 29  ? 26.76010  0.40439   22.20827  1.000 12.89195 ?  29  VAL A C   1 
ATOM   212  O  O   . VAL A 1 29  ? 27.08564  -0.77472  22.03293  1.000 9.79218  ?  29  VAL A O   1 
ATOM   213  C  CB  . VAL A 1 29  ? 27.61689  2.01162   20.43409  1.000 16.05692 ?  29  VAL A CB  1 
ATOM   214  C  CG1 . VAL A 1 29  ? 27.77718  0.84057   19.48139  1.000 18.98515 ?  29  VAL A CG1 1 
ATOM   215  C  CG2 . VAL A 1 29  ? 26.30279  2.75327   20.16945  1.000 15.55090 ?  29  VAL A CG2 1 
ATOM   216  N  N   . ASP A 1 30  ? 25.59082  0.75137   22.72703  1.000 12.38664 ?  30  ASP A N   1 
ATOM   217  C  CA  . ASP A 1 30  ? 24.50819  -0.20610  22.91133  1.000 9.92181  ?  30  ASP A CA  1 
ATOM   218  C  C   . ASP A 1 30  ? 23.86845  -0.41213  21.55085  1.000 12.97558 ?  30  ASP A C   1 
ATOM   219  O  O   . ASP A 1 30  ? 23.24858  0.51584   21.01615  1.000 10.67942 ?  30  ASP A O   1 
ATOM   220  C  CB  . ASP A 1 30  ? 23.50009  0.34509   23.90960  1.000 12.69252 ?  30  ASP A CB  1 
ATOM   221  C  CG  . ASP A 1 30  ? 22.43320  -0.66869  24.31588  1.000 11.48036 ?  30  ASP A CG  1 
ATOM   222  O  OD1 . ASP A 1 30  ? 22.15593  -1.63215  23.58331  1.000 7.03747  ?  30  ASP A OD1 1 
ATOM   223  O  OD2 . ASP A 1 30  ? 21.85980  -0.47158  25.39548  1.000 10.86060 -1 30  ASP A OD2 1 
ATOM   224  N  N   . ASP A 1 31  ? 24.03018  -1.61200  20.97551  1.000 11.64685 ?  31  ASP A N   1 
ATOM   225  C  CA  . ASP A 1 31  ? 23.47638  -1.88207  19.65077  1.000 15.03623 ?  31  ASP A CA  1 
ATOM   226  C  C   . ASP A 1 31  ? 21.96463  -2.04959  19.65918  1.000 13.73760 ?  31  ASP A C   1 
ATOM   227  O  O   . ASP A 1 31  ? 21.36590  -2.12673  18.58515  1.000 17.23046 ?  31  ASP A O   1 
ATOM   228  C  CB  . ASP A 1 31  ? 24.08141  -3.15258  19.04761  1.000 15.92629 ?  31  ASP A CB  1 
ATOM   229  C  CG  . ASP A 1 31  ? 25.56223  -3.03192  18.78763  1.000 25.74989 ?  31  ASP A CG  1 
ATOM   230  O  OD1 . ASP A 1 31  ? 26.00657  -1.96156  18.31467  1.000 29.15583 ?  31  ASP A OD1 1 
ATOM   231  O  OD2 . ASP A 1 31  ? 26.28038  -4.01629  19.06753  1.000 35.22082 -1 31  ASP A OD2 1 
ATOM   232  N  N   . TYR A 1 32  ? 21.33130  -2.13857  20.82612  1.000 12.11939 ?  32  TYR A N   1 
ATOM   233  C  CA  . TYR A 1 32  ? 19.93360  -2.53911  20.86205  1.000 10.40009 ?  32  TYR A CA  1 
ATOM   234  C  C   . TYR A 1 32  ? 18.97950  -1.44948  21.30146  1.000 12.89380 ?  32  TYR A C   1 
ATOM   235  O  O   . TYR A 1 32  ? 17.78154  -1.55827  21.01827  1.000 9.67264  ?  32  TYR A O   1 
ATOM   236  C  CB  . TYR A 1 32  ? 19.73972  -3.74480  21.79232  1.000 10.84053 ?  32  TYR A CB  1 
ATOM   237  C  CG  . TYR A 1 32  ? 20.66710  -4.90595  21.48796  1.000 12.44445 ?  32  TYR A CG  1 
ATOM   238  C  CD1 . TYR A 1 32  ? 21.92495  -4.98928  22.08244  1.000 12.95903 ?  32  TYR A CD1 1 
ATOM   239  C  CD2 . TYR A 1 32  ? 20.29017  -5.89971  20.59060  1.000 12.79955 ?  32  TYR A CD2 1 
ATOM   240  C  CE1 . TYR A 1 32  ? 22.78430  -6.05200  21.79656  1.000 12.40964 ?  32  TYR A CE1 1 
ATOM   241  C  CE2 . TYR A 1 32  ? 21.13408  -6.96676  20.29726  1.000 15.48698 ?  32  TYR A CE2 1 
ATOM   242  C  CZ  . TYR A 1 32  ? 22.38356  -7.03298  20.90699  1.000 15.78075 ?  32  TYR A CZ  1 
ATOM   243  O  OH  . TYR A 1 32  ? 23.23448  -8.08090  20.62878  1.000 19.00209 ?  32  TYR A OH  1 
ATOM   244  N  N   . MET A 1 33  ? 19.45518  -0.43592  22.01679  1.000 12.83358 ?  33  MET A N   1 
ATOM   245  C  CA  A MET A 1 33  ? 18.60806  0.62755   22.54141  0.516 12.52364 ?  33  MET A CA  1 
ATOM   246  C  CA  B MET A 1 33  ? 18.58102  0.63218   22.47216  0.484 12.73083 ?  33  MET A CA  1 
ATOM   247  C  C   . MET A 1 33  ? 19.29578  1.96299   22.34368  1.000 11.46227 ?  33  MET A C   1 
ATOM   248  O  O   . MET A 1 33  ? 20.52295  2.04682   22.42069  1.000 10.51484 ?  33  MET A O   1 
ATOM   249  C  CB  A MET A 1 33  ? 18.33363  0.44609   24.03086  0.516 12.23748 ?  33  MET A CB  1 
ATOM   250  C  CB  B MET A 1 33  ? 18.11229  0.41805   23.91686  0.484 12.53769 ?  33  MET A CB  1 
ATOM   251  C  CG  A MET A 1 33  ? 18.08312  -0.98540  24.44288  0.516 16.38756 ?  33  MET A CG  1 
ATOM   252  C  CG  B MET A 1 33  ? 16.95794  -0.58824  24.04932  0.484 15.70346 ?  33  MET A CG  1 
ATOM   253  S  SD  A MET A 1 33  ? 16.66825  -1.08172  25.54302  0.516 33.12380 ?  33  MET A SD  1 
ATOM   254  S  SD  B MET A 1 33  ? 16.37550  -0.80266  25.74559  0.484 32.30380 ?  33  MET A SD  1 
ATOM   255  C  CE  A MET A 1 33  ? 15.42467  -0.46542  24.42448  0.516 13.95909 ?  33  MET A CE  1 
ATOM   256  C  CE  B MET A 1 33  ? 15.45105  0.71154   25.98007  0.484 16.73693 ?  33  MET A CE  1 
ATOM   257  N  N   . GLY A 1 34  ? 18.50189  3.00689   22.11518  1.000 12.01989 ?  34  GLY A N   1 
ATOM   258  C  CA  . GLY A 1 34  ? 19.01333  4.36096   22.12869  1.000 11.69191 ?  34  GLY A CA  1 
ATOM   259  C  C   . GLY A 1 34  ? 19.47028  4.88743   20.79388  1.000 10.96438 ?  34  GLY A C   1 
ATOM   260  O  O   . GLY A 1 34  ? 19.84435  6.06556   20.71135  1.000 12.78191 ?  34  GLY A O   1 
ATOM   261  N  N   . ASN A 1 35  ? 19.47688  4.05037   19.75561  1.000 9.88258  ?  35  ASN A N   1 
ATOM   262  C  CA  . ASN A 1 35  ? 19.73867  4.50238   18.39946  1.000 11.89976 ?  35  ASN A CA  1 
ATOM   263  C  C   . ASN A 1 35  ? 21.02537  5.31500   18.32466  1.000 11.47439 ?  35  ASN A C   1 
ATOM   264  O  O   . ASN A 1 35  ? 21.06814  6.42208   17.78068  1.000 12.77006 ?  35  ASN A O   1 
ATOM   265  C  CB  . ASN A 1 35  ? 18.53480  5.27920   17.88156  1.000 13.76853 ?  35  ASN A CB  1 
ATOM   266  C  CG  . ASN A 1 35  ? 17.37679  4.35957   17.59700  1.000 14.51370 ?  35  ASN A CG  1 
ATOM   267  O  OD1 . ASN A 1 35  ? 17.40265  3.63527   16.59645  1.000 11.70673 ?  35  ASN A OD1 1 
ATOM   268  N  ND2 . ASN A 1 35  ? 16.38622  4.32597   18.49598  1.000 9.56872  ?  35  ASN A ND2 1 
ATOM   269  N  N   . GLY A 1 36  ? 22.08166  4.74646   18.90161  1.000 10.28184 ?  36  GLY A N   1 
ATOM   270  C  CA  . GLY A 1 36  ? 23.40710  5.31938   18.85327  1.000 13.94208 ?  36  GLY A CA  1 
ATOM   271  C  C   . GLY A 1 36  ? 23.73262  6.28731   19.97209  1.000 14.79051 ?  36  GLY A C   1 
ATOM   272  O  O   . GLY A 1 36  ? 24.88980  6.70492   20.08443  1.000 14.73794 ?  36  GLY A O   1 
ATOM   273  N  N   . THR A 1 37  ? 22.75202  6.68121   20.78959  1.000 12.69181 ?  37  THR A N   1 
ATOM   274  C  CA  . THR A 1 37  ? 23.00321  7.62046   21.87724  1.000 11.42410 ?  37  THR A CA  1 
ATOM   275  C  C   . THR A 1 37  ? 23.42237  6.93450   23.15954  1.000 9.01457  ?  37  THR A C   1 
ATOM   276  O  O   . THR A 1 37  ? 23.74539  7.61911   24.13317  1.000 9.01634  ?  37  THR A O   1 
ATOM   277  C  CB  . THR A 1 37  ? 21.75511  8.45434   22.18733  1.000 11.44125 ?  37  THR A CB  1 
ATOM   278  O  OG1 . THR A 1 37  ? 20.74058  7.59696   22.73526  1.000 12.91830 ?  37  THR A OG1 1 
ATOM   279  C  CG2 . THR A 1 37  ? 21.23053  9.14132   20.94455  1.000 12.11684 ?  37  THR A CG2 1 
ATOM   280  N  N   . ARG A 1 38  ? 23.39072  5.61096   23.21090  1.000 9.53947  ?  38  ARG A N   1 
ATOM   281  C  CA  . ARG A 1 38  ? 23.60787  4.90792   24.46378  1.000 8.92146  ?  38  ARG A CA  1 
ATOM   282  C  C   . ARG A 1 38  ? 24.81247  3.98564   24.35311  1.000 11.27272 ?  38  ARG A C   1 
ATOM   283  O  O   . ARG A 1 38  ? 25.05825  3.38331   23.29973  1.000 9.06171  ?  38  ARG A O   1 
ATOM   284  C  CB  . ARG A 1 38  ? 22.37364  4.10134   24.86825  1.000 10.08724 ?  38  ARG A CB  1 
ATOM   285  C  CG  . ARG A 1 38  ? 22.48882  3.46949   26.25646  1.000 7.89140  ?  38  ARG A CG  1 
ATOM   286  C  CD  . ARG A 1 38  ? 21.18597  2.84993   26.72591  1.000 13.09164 ?  38  ARG A CD  1 
ATOM   287  N  NE  . ARG A 1 38  ? 20.08541  3.80033   26.77957  1.000 14.39718 ?  38  ARG A NE  1 
ATOM   288  C  CZ  . ARG A 1 38  ? 18.85333  3.46491   27.13137  1.000 18.38097 ?  38  ARG A CZ  1 
ATOM   289  N  NH1 . ARG A 1 38  ? 18.56055  2.23168   27.50966  1.000 11.97006 ?  38  ARG A NH1 1 
ATOM   290  N  NH2 . ARG A 1 38  ? 17.89252  4.38462   27.09479  1.000 11.81058 ?  38  ARG A NH2 1 
ATOM   291  N  N   . PHE A 1 39  ? 25.53931  3.87404   25.45868  1.000 10.67928 ?  39  PHE A N   1 
ATOM   292  C  CA  . PHE A 1 39  ? 26.75004  3.07586   25.57340  1.000 8.05593  ?  39  PHE A CA  1 
ATOM   293  C  C   . PHE A 1 39  ? 26.67657  2.31156   26.89013  1.000 11.56251 ?  39  PHE A C   1 
ATOM   294  O  O   . PHE A 1 39  ? 26.18126  2.84380   27.89098  1.000 10.95424 ?  39  PHE A O   1 
ATOM   295  C  CB  . PHE A 1 39  ? 27.99528  3.97004   25.51730  1.000 8.23087  ?  39  PHE A CB  1 
ATOM   296  C  CG  . PHE A 1 39  ? 28.03303  4.86462   24.31005  1.000 11.39325 ?  39  PHE A CG  1 
ATOM   297  C  CD1 . PHE A 1 39  ? 27.28389  6.02801   24.26871  1.000 11.94307 ?  39  PHE A CD1 1 
ATOM   298  C  CD2 . PHE A 1 39  ? 28.80974  4.52527   23.20508  1.000 14.72040 ?  39  PHE A CD2 1 
ATOM   299  C  CE1 . PHE A 1 39  ? 27.30033  6.84637   23.14005  1.000 11.20562 ?  39  PHE A CE1 1 
ATOM   300  C  CE2 . PHE A 1 39  ? 28.82608  5.32338   22.07145  1.000 15.43147 ?  39  PHE A CE2 1 
ATOM   301  C  CZ  . PHE A 1 39  ? 28.07063  6.48837   22.03961  1.000 17.22131 ?  39  PHE A CZ  1 
ATOM   302  N  N   . LYS A 1 40  ? 27.13916  1.05702   26.88664  1.000 8.32772  ?  40  LYS A N   1 
ATOM   303  C  CA  . LYS A 1 40  ? 26.71184  0.13406   27.92685  1.000 11.34634 ?  40  LYS A CA  1 
ATOM   304  C  C   . LYS A 1 40  ? 27.71617  -0.97970  28.18107  1.000 11.04278 ?  40  LYS A C   1 
ATOM   305  O  O   . LYS A 1 40  ? 28.30786  -1.51946  27.24527  1.000 10.45667 ?  40  LYS A O   1 
ATOM   306  C  CB  . LYS A 1 40  ? 25.36874  -0.49736  27.54477  1.000 12.29749 ?  40  LYS A CB  1 
ATOM   307  C  CG  . LYS A 1 40  ? 24.87397  -1.48906  28.55782  1.000 16.38835 ?  40  LYS A CG  1 
ATOM   308  C  CD  . LYS A 1 40  ? 23.58610  -2.09560  28.11356  1.000 17.37846 ?  40  LYS A CD  1 
ATOM   309  C  CE  . LYS A 1 40  ? 22.75768  -2.44216  29.30582  1.000 19.47267 ?  40  LYS A CE  1 
ATOM   310  N  NZ  . LYS A 1 40  ? 21.95244  -1.29445  29.78261  1.000 17.69446 ?  40  LYS A NZ  1 
ATOM   311  N  N   . ARG A 1 41  ? 27.85903  -1.35158  29.45328  1.000 9.04018  ?  41  ARG A N   1 
ATOM   312  C  CA  . ARG A 1 41  ? 28.41230  -2.64428  29.83872  1.000 9.59578  ?  41  ARG A CA  1 
ATOM   313  C  C   . ARG A 1 41  ? 27.46256  -3.24942  30.85665  1.000 8.41158  ?  41  ARG A C   1 
ATOM   314  O  O   . ARG A 1 41  ? 26.64603  -2.53829  31.44988  1.000 10.16883 ?  41  ARG A O   1 
ATOM   315  C  CB  . ARG A 1 41  ? 29.84404  -2.53266  30.41263  1.000 10.74582 ?  41  ARG A CB  1 
ATOM   316  C  CG  . ARG A 1 41  ? 30.90178  -2.09601  29.38421  1.000 6.71507  ?  41  ARG A CG  1 
ATOM   317  C  CD  . ARG A 1 41  ? 32.30442  -2.02747  30.02703  1.000 9.75788  ?  41  ARG A CD  1 
ATOM   318  N  NE  . ARG A 1 41  ? 33.31693  -1.71853  29.02251  1.000 12.46380 ?  41  ARG A NE  1 
ATOM   319  C  CZ  . ARG A 1 41  ? 33.99733  -2.63353  28.34463  1.000 13.93790 ?  41  ARG A CZ  1 
ATOM   320  N  NH1 . ARG A 1 41  ? 33.83992  -3.93052  28.58657  1.000 11.92723 ?  41  ARG A NH1 1 
ATOM   321  N  NH2 . ARG A 1 41  ? 34.86781  -2.23924  27.41201  1.000 13.14894 ?  41  ARG A NH2 1 
ATOM   322  N  N   . PHE A 1 42  ? 27.57797  -4.56221  31.06798  1.000 8.97210  ?  42  PHE A N   1 
ATOM   323  C  CA  . PHE A 1 42  ? 26.56371  -5.32383  31.79635  1.000 7.28043  ?  42  PHE A CA  1 
ATOM   324  C  C   . PHE A 1 42  ? 27.20734  -6.48138  32.53400  1.000 12.21403 ?  42  PHE A C   1 
ATOM   325  O  O   . PHE A 1 42  ? 28.00411  -7.22327  31.94958  1.000 15.12733 ?  42  PHE A O   1 
ATOM   326  C  CB  . PHE A 1 42  ? 25.49993  -5.83321  30.81509  1.000 10.22486 ?  42  PHE A CB  1 
ATOM   327  C  CG  . PHE A 1 42  ? 24.49844  -6.81479  31.40226  1.000 12.27123 ?  42  PHE A CG  1 
ATOM   328  C  CD1 . PHE A 1 42  ? 23.42030  -6.35725  32.16539  1.000 12.15062 ?  42  PHE A CD1 1 
ATOM   329  C  CD2 . PHE A 1 42  ? 24.59879  -8.18453  31.12705  1.000 11.12210 ?  42  PHE A CD2 1 
ATOM   330  C  CE1 . PHE A 1 42  ? 22.45420  -7.24418  32.67857  1.000 7.28066  ?  42  PHE A CE1 1 
ATOM   331  C  CE2 . PHE A 1 42  ? 23.65061  -9.09766  31.63759  1.000 11.57905 ?  42  PHE A CE2 1 
ATOM   332  C  CZ  . PHE A 1 42  ? 22.56412  -8.62204  32.40965  1.000 9.10434  ?  42  PHE A CZ  1 
ATOM   333  N  N   . SER A 1 43  ? 26.89599  -6.61680  33.82018  1.000 8.32941  ?  43  SER A N   1 
ATOM   334  C  CA  A SER A 1 43  ? 27.31476  -7.78470  34.57827  0.852 9.42759  ?  43  SER A CA  1 
ATOM   335  C  CA  B SER A 1 43  ? 27.31698  -7.78230  34.58248  0.148 10.52282 ?  43  SER A CA  1 
ATOM   336  C  C   . SER A 1 43  ? 26.21197  -8.17581  35.55171  1.000 13.53934 ?  43  SER A C   1 
ATOM   337  O  O   . SER A 1 43  ? 25.32583  -7.37549  35.88551  1.000 8.94736  ?  43  SER A O   1 
ATOM   338  C  CB  A SER A 1 43  ? 28.63317  -7.53662  35.33064  0.852 12.79936 ?  43  SER A CB  1 
ATOM   339  C  CB  B SER A 1 43  ? 28.63963  -7.53752  35.33708  0.148 12.50493 ?  43  SER A CB  1 
ATOM   340  O  OG  A SER A 1 43  ? 29.68323  -7.27467  34.41840  0.852 8.45120  ?  43  SER A OG  1 
ATOM   341  O  OG  B SER A 1 43  ? 28.55849  -6.44366  36.23320  0.148 10.43318 ?  43  SER A OG  1 
ATOM   342  N  N   . GLN A 1 44  ? 26.27642  -9.42532  36.00591  1.000 11.22789 ?  44  GLN A N   1 
ATOM   343  C  CA  . GLN A 1 44  ? 25.29730  -9.96245  36.93392  1.000 13.27487 ?  44  GLN A CA  1 
ATOM   344  C  C   . GLN A 1 44  ? 26.01872  -10.53795 38.13610  1.000 13.77975 ?  44  GLN A C   1 
ATOM   345  O  O   . GLN A 1 44  ? 27.11582  -11.08482 38.00258  1.000 15.89131 ?  44  GLN A O   1 
ATOM   346  C  CB  . GLN A 1 44  ? 24.42187  -11.01934 36.23995  1.000 9.46728  ?  44  GLN A CB  1 
ATOM   347  C  CG  . GLN A 1 44  ? 23.59831  -10.38677 35.14534  1.000 10.04982 ?  44  GLN A CG  1 
ATOM   348  C  CD  . GLN A 1 44  ? 22.94990  -11.37147 34.21761  1.000 14.62199 ?  44  GLN A CD  1 
ATOM   349  O  OE1 . GLN A 1 44  ? 23.61294  -11.99581 33.38412  1.000 9.51407  ?  44  GLN A OE1 1 
ATOM   350  N  NE2 . GLN A 1 44  ? 21.62431  -11.50056 34.33216  1.000 9.57903  ?  44  GLN A NE2 1 
ATOM   351  N  N   . TYR A 1 45  ? 25.42233  -10.37904 39.31471  1.000 10.18030 ?  45  TYR A N   1 
ATOM   352  C  CA  . TYR A 1 45  ? 26.02915  -10.87226 40.53951  1.000 11.54502 ?  45  TYR A CA  1 
ATOM   353  C  C   . TYR A 1 45  ? 25.01145  -11.66154 41.32637  1.000 15.25002 ?  45  TYR A C   1 
ATOM   354  O  O   . TYR A 1 45  ? 23.80320  -11.40262 41.26094  1.000 12.78115 ?  45  TYR A O   1 
ATOM   355  C  CB  . TYR A 1 45  ? 26.55613  -9.77467  41.47983  1.000 8.30939  ?  45  TYR A CB  1 
ATOM   356  C  CG  . TYR A 1 45  ? 27.69853  -8.95029  40.94913  1.000 13.45125 ?  45  TYR A CG  1 
ATOM   357  C  CD1 . TYR A 1 45  ? 27.47092  -7.89001  40.08834  1.000 14.69388 ?  45  TYR A CD1 1 
ATOM   358  C  CD2 . TYR A 1 45  ? 29.00693  -9.20069  41.34760  1.000 18.81374 ?  45  TYR A CD2 1 
ATOM   359  C  CE1 . TYR A 1 45  ? 28.51765  -7.11346  39.61337  1.000 14.18214 ?  45  TYR A CE1 1 
ATOM   360  C  CE2 . TYR A 1 45  ? 30.06226  -8.42707  40.87868  1.000 19.44114 ?  45  TYR A CE2 1 
ATOM   361  C  CZ  . TYR A 1 45  ? 29.80231  -7.38706  40.00688  1.000 14.87517 ?  45  TYR A CZ  1 
ATOM   362  O  OH  . TYR A 1 45  ? 30.83302  -6.62042  39.53623  1.000 18.56207 ?  45  TYR A OH  1 
ATOM   363  N  N   . LYS A 1 46  ? 25.53572  -12.62073 42.07824  1.000 13.14428 ?  46  LYS A N   1 
ATOM   364  C  CA  . LYS A 1 46  ? 24.82742  -13.24903 43.17426  1.000 11.84630 ?  46  LYS A CA  1 
ATOM   365  C  C   . LYS A 1 46  ? 25.14991  -12.49276 44.45710  1.000 15.17141 ?  46  LYS A C   1 
ATOM   366  O  O   . LYS A 1 46  ? 26.31592  -12.16362 44.72255  1.000 14.38175 ?  46  LYS A O   1 
ATOM   367  C  CB  . LYS A 1 46  ? 25.22687  -14.72058 43.29947  1.000 14.16402 ?  46  LYS A CB  1 
ATOM   368  C  CG  . LYS A 1 46  ? 24.62772  -15.44103 44.50234  1.000 12.99303 ?  46  LYS A CG  1 
ATOM   369  C  CD  . LYS A 1 46  ? 25.07607  -16.91085 44.45070  1.000 17.17672 ?  46  LYS A CD  1 
ATOM   370  C  CE  . LYS A 1 46  ? 24.35734  -17.75999 45.44750  1.000 17.34198 ?  46  LYS A CE  1 
ATOM   371  N  NZ  . LYS A 1 46  ? 24.92053  -19.13060 45.49658  1.000 15.61199 ?  46  LYS A NZ  1 
ATOM   372  N  N   . LEU A 1 47  ? 24.10865  -12.19453 45.22689  1.000 14.34138 ?  47  LEU A N   1 
ATOM   373  C  CA  . LEU A 1 47  ? 24.20620  -11.51127 46.50771  1.000 16.66075 ?  47  LEU A CA  1 
ATOM   374  C  C   . LEU A 1 47  ? 23.82017  -12.49626 47.59313  1.000 19.37377 ?  47  LEU A C   1 
ATOM   375  O  O   . LEU A 1 47  ? 22.64025  -12.83862 47.71891  1.000 19.73439 ?  47  LEU A O   1 
ATOM   376  C  CB  . LEU A 1 47  ? 23.24949  -10.32775 46.60050  1.000 18.27109 ?  47  LEU A CB  1 
ATOM   377  C  CG  . LEU A 1 47  ? 23.36582  -9.13940  45.69943  1.000 17.65146 ?  47  LEU A CG  1 
ATOM   378  C  CD1 . LEU A 1 47  ? 22.38732  -8.05108  46.19890  1.000 14.15636 ?  47  LEU A CD1 1 
ATOM   379  C  CD2 . LEU A 1 47  ? 24.78583  -8.71268  45.79157  1.000 24.81380 ?  47  LEU A CD2 1 
ATOM   380  N  N   . THR A 1 48  ? 24.78461  -12.89588 48.40974  1.000 25.75700 ?  48  THR A N   1 
ATOM   381  C  CA  . THR A 1 48  ? 24.45068  -13.84980 49.44243  1.000 25.28488 ?  48  THR A CA  1 
ATOM   382  C  C   . THR A 1 48  ? 24.56551  -13.20513 50.81189  1.000 27.34205 ?  48  THR A C   1 
ATOM   383  O  O   . THR A 1 48  ? 25.50934  -12.45180 51.06819  1.000 31.46460 ?  48  THR A O   1 
ATOM   384  C  CB  . THR A 1 48  ? 25.36945  -15.07323 49.38794  1.000 28.40713 ?  48  THR A CB  1 
ATOM   385  O  OG1 . THR A 1 48  ? 26.70950  -14.67334 49.70556  1.000 37.60666 ?  48  THR A OG1 1 
ATOM   386  C  CG2 . THR A 1 48  ? 25.35756  -15.65224 48.00977  1.000 16.34780 ?  48  THR A CG2 1 
ATOM   387  N  N   . PRO A 1 49  ? 23.60518  -13.45510 51.69375  1.000 30.81025 ?  49  PRO A N   1 
ATOM   388  C  CA  . PRO A 1 49  ? 23.78881  -13.09282 53.09788  1.000 30.76616 ?  49  PRO A CA  1 
ATOM   389  C  C   . PRO A 1 49  ? 24.98594  -13.85104 53.65335  1.000 31.26379 ?  49  PRO A C   1 
ATOM   390  O  O   . PRO A 1 49  ? 25.07171  -15.08093 53.55436  1.000 30.98705 ?  49  PRO A O   1 
ATOM   391  C  CB  . PRO A 1 49  ? 22.47003  -13.52582 53.74983  1.000 30.58335 ?  49  PRO A CB  1 
ATOM   392  C  CG  . PRO A 1 49  ? 21.50476  -13.69057 52.58947  1.000 26.64398 ?  49  PRO A CG  1 
ATOM   393  C  CD  . PRO A 1 49  ? 22.34963  -14.18258 51.46905  1.000 20.92403 ?  49  PRO A CD  1 
ATOM   394  N  N   . ALA A 1 50  ? 25.94962  -13.09568 54.15487  1.000 31.81884 ?  50  ALA A N   1 
ATOM   395  C  CA  . ALA A 1 50  ? 27.15493  -13.63315 54.75851  1.000 38.86591 ?  50  ALA A CA  1 
ATOM   396  C  C   . ALA A 1 50  ? 27.10393  -13.34315 56.24992  1.000 42.46378 ?  50  ALA A C   1 
ATOM   397  O  O   . ALA A 1 50  ? 26.27485  -12.55800 56.72112  1.000 52.82380 ?  50  ALA A O   1 
ATOM   398  C  CB  . ALA A 1 50  ? 28.41262  -13.02470 54.12506  1.000 30.69380 ?  50  ALA A CB  1 
ATOM   399  N  N   . GLU A 1 51  ? 27.99171  -13.97926 57.00695  1.000 40.61530 ?  51  GLU A N   1 
ATOM   400  C  CA  . GLU A 1 51  ? 27.97353  -13.72919 58.43867  1.000 55.11429 ?  51  GLU A CA  1 
ATOM   401  C  C   . GLU A 1 51  ? 28.22459  -12.25041 58.72901  1.000 48.28349 ?  51  GLU A C   1 
ATOM   402  O  O   . GLU A 1 51  ? 28.70552  -11.49370 57.88010  1.000 41.88067 ?  51  GLU A O   1 
ATOM   403  C  CB  . GLU A 1 51  ? 28.99783  -14.60370 59.16124  1.000 54.85178 ?  51  GLU A CB  1 
ATOM   404  C  CG  . GLU A 1 51  ? 28.41262  -15.35468 60.36337  1.000 53.05854 ?  51  GLU A CG  1 
ATOM   405  C  CD  . GLU A 1 51  ? 26.94540  -15.00702 60.63867  1.000 61.58905 ?  51  GLU A CD  1 
ATOM   406  O  OE1 . GLU A 1 51  ? 26.03421  -15.49606 59.91824  1.000 48.23380 ?  51  GLU A OE1 1 
ATOM   407  O  OE2 . GLU A 1 51  ? 26.70965  -14.22983 61.58823  1.000 65.27136 -1 51  GLU A OE2 1 
ATOM   408  N  N   . ASP A 1 52  ? 27.83035  -11.84010 59.93741  1.000 50.95974 ?  52  ASP A N   1 
ATOM   409  C  CA  . ASP A 1 52  ? 28.10142  -10.50332 60.47533  1.000 55.70292 ?  52  ASP A CA  1 
ATOM   410  C  C   . ASP A 1 52  ? 27.25644  -9.42508  59.79959  1.000 55.96383 ?  52  ASP A C   1 
ATOM   411  O  O   . ASP A 1 52  ? 27.69914  -8.28171  59.66978  1.000 57.30380 ?  52  ASP A O   1 
ATOM   412  C  CB  . ASP A 1 52  ? 29.59349  -10.14975 60.39088  1.000 61.14358 ?  52  ASP A CB  1 
ATOM   413  C  CG  . ASP A 1 52  ? 30.46422  -11.12658 61.15285  1.000 72.75619 ?  52  ASP A CG  1 
ATOM   414  O  OD1 . ASP A 1 52  ? 30.19714  -11.34383 62.35697  1.000 76.43206 ?  52  ASP A OD1 1 
ATOM   415  O  OD2 . ASP A 1 52  ? 31.39964  -11.69537 60.53923  1.000 73.81190 -1 52  ASP A OD2 1 
ATOM   416  N  N   . ASP A 1 53  ? 26.03645  -9.78502  59.37406  1.000 53.75171 ?  53  ASP A N   1 
ATOM   417  C  CA  . ASP A 1 53  ? 25.10528  -8.82130  58.77552  1.000 54.67952 ?  53  ASP A CA  1 
ATOM   418  C  C   . ASP A 1 53  ? 25.72055  -8.16824  57.53801  1.000 50.16628 ?  53  ASP A C   1 
ATOM   419  O  O   . ASP A 1 53  ? 25.48529  -6.99572  57.22984  1.000 50.85032 ?  53  ASP A O   1 
ATOM   420  C  CB  . ASP A 1 53  ? 24.67878  -7.76516  59.79954  1.000 56.48874 ?  53  ASP A CB  1 
ATOM   421  C  CG  . ASP A 1 53  ? 23.44219  -6.99956  59.37593  1.000 64.07382 ?  53  ASP A CG  1 
ATOM   422  O  OD1 . ASP A 1 53  ? 22.57249  -7.58990  58.69348  1.000 57.73380 -1 53  ASP A OD1 1 
ATOM   423  O  OD2 . ASP A 1 53  ? 23.35471  -5.79704  59.71967  1.000 65.59012 ?  53  ASP A OD2 1 
ATOM   424  N  N   . THR A 1 54  ? 26.53261  -8.93939  56.83159  1.000 46.58380 ?  54  THR A N   1 
ATOM   425  C  CA  . THR A 1 54  ? 27.21121  -8.48617  55.63208  1.000 43.18462 ?  54  THR A CA  1 
ATOM   426  C  C   . THR A 1 54  ? 26.65135  -9.20979  54.42215  1.000 43.17380 ?  54  THR A C   1 
ATOM   427  O  O   . THR A 1 54  ? 26.01584  -10.26245 54.53040  1.000 41.47430 ?  54  THR A O   1 
ATOM   428  C  CB  . THR A 1 54  ? 28.72233  -8.74523  55.70269  1.000 42.44328 ?  54  THR A CB  1 
ATOM   429  O  OG1 . THR A 1 54  ? 28.94837  -10.16156 55.82274  1.000 40.62106 ?  54  THR A OG1 1 
ATOM   430  C  CG2 . THR A 1 54  ? 29.33924  -8.01976  56.87864  1.000 49.15989 ?  54  THR A CG2 1 
ATOM   431  N  N   . TRP A 1 55  ? 26.92617  -8.64674  53.25872  1.000 32.81417 ?  55  TRP A N   1 
ATOM   432  C  CA  . TRP A 1 55  ? 26.52657  -9.25027  52.00303  1.000 33.63671 ?  55  TRP A CA  1 
ATOM   433  C  C   . TRP A 1 55  ? 27.75237  -9.54187  51.15196  1.000 28.76818 ?  55  TRP A C   1 
ATOM   434  O  O   . TRP A 1 55  ? 28.66044  -8.71622  51.04615  1.000 26.05182 ?  55  TRP A O   1 
ATOM   435  C  CB  . TRP A 1 55  ? 25.56109  -8.34631  51.23953  1.000 32.78380 ?  55  TRP A CB  1 
ATOM   436  C  CG  . TRP A 1 55  ? 24.20076  -8.28540  51.82540  1.000 24.33467 ?  55  TRP A CG  1 
ATOM   437  C  CD1 . TRP A 1 55  ? 23.76395  -7.42805  52.78810  1.000 28.56912 ?  55  TRP A CD1 1 
ATOM   438  C  CD2 . TRP A 1 55  ? 23.08022  -9.10000  51.47359  1.000 21.57255 ?  55  TRP A CD2 1 
ATOM   439  N  NE1 . TRP A 1 55  ? 22.43358  -7.65636  53.05660  1.000 24.73341 ?  55  TRP A NE1 1 
ATOM   440  C  CE2 . TRP A 1 55  ? 21.99192  -8.68057  52.26428  1.000 21.45700 ?  55  TRP A CE2 1 
ATOM   441  C  CE3 . TRP A 1 55  ? 22.88742  -10.13195 50.55747  1.000 22.23293 ?  55  TRP A CE3 1 
ATOM   442  C  CZ2 . TRP A 1 55  ? 20.73071  -9.25823  52.16607  1.000 20.71527 ?  55  TRP A CZ2 1 
ATOM   443  C  CZ3 . TRP A 1 55  ? 21.64056  -10.71519 50.47061  1.000 26.66305 ?  55  TRP A CZ3 1 
ATOM   444  C  CH2 . TRP A 1 55  ? 20.57675  -10.27703 51.26971  1.000 28.74682 ?  55  TRP A CH2 1 
ATOM   445  N  N   . SER A 1 56  ? 27.77446  -10.72487 50.55695  1.000 22.88080 ?  56  SER A N   1 
ATOM   446  C  CA  . SER A 1 56  ? 28.85036  -11.13376 49.67001  1.000 30.76149 ?  56  SER A CA  1 
ATOM   447  C  C   . SER A 1 56  ? 28.38239  -11.01075 48.22484  1.000 25.58850 ?  56  SER A C   1 
ATOM   448  O  O   . SER A 1 56  ? 27.27230  -11.42783 47.89163  1.000 26.03401 ?  56  SER A O   1 
ATOM   449  C  CB  . SER A 1 56  ? 29.27895  -12.57048 49.97116  1.000 30.79398 ?  56  SER A CB  1 
ATOM   450  O  OG  . SER A 1 56  ? 30.18790  -13.04829 48.98794  1.000 40.12380 ?  56  SER A OG  1 
ATOM   451  N  N   . PHE A 1 57  ? 29.21754  -10.42341 47.37436  1.000 20.97320 ?  57  PHE A N   1 
ATOM   452  C  CA  . PHE A 1 57  ? 28.94245  -10.31674 45.94681  1.000 18.83004 ?  57  PHE A CA  1 
ATOM   453  C  C   . PHE A 1 57  ? 29.77813  -11.34667 45.20865  1.000 19.05304 ?  57  PHE A C   1 
ATOM   454  O  O   . PHE A 1 57  ? 30.98440  -11.43977 45.44327  1.000 23.94370 ?  57  PHE A O   1 
ATOM   455  C  CB  . PHE A 1 57  ? 29.29807  -8.93928  45.38469  1.000 12.47869 ?  57  PHE A CB  1 
ATOM   456  C  CG  . PHE A 1 57  ? 28.50588  -7.80818  45.94352  1.000 16.03667 ?  57  PHE A CG  1 
ATOM   457  C  CD1 . PHE A 1 57  ? 28.68308  -7.39737  47.25584  1.000 20.22386 ?  57  PHE A CD1 1 
ATOM   458  C  CD2 . PHE A 1 57  ? 27.63407  -7.09915  45.12936  1.000 17.89980 ?  57  PHE A CD2 1 
ATOM   459  C  CE1 . PHE A 1 57  ? 27.97792  -6.32406  47.76134  1.000 20.94316 ?  57  PHE A CE1 1 
ATOM   460  C  CE2 . PHE A 1 57  ? 26.92021  -6.01923  45.62364  1.000 17.60684 ?  57  PHE A CE2 1 
ATOM   461  C  CZ  . PHE A 1 57  ? 27.08673  -5.63320  46.94410  1.000 18.29444 ?  57  PHE A CZ  1 
ATOM   462  N  N   . LYS A 1 58  ? 29.15860  -12.08897 44.29510  1.000 18.27384 ?  58  LYS A N   1 
ATOM   463  C  CA  . LYS A 1 58  ? 29.89296  -12.99564 43.41748  1.000 19.27196 ?  58  LYS A CA  1 
ATOM   464  C  C   . LYS A 1 58  ? 29.48522  -12.73596 41.97756  1.000 16.48832 ?  58  LYS A C   1 
ATOM   465  O  O   . LYS A 1 58  ? 28.30900  -12.88711 41.62108  1.000 15.24710 ?  58  LYS A O   1 
ATOM   466  C  CB  . LYS A 1 58  ? 29.66454  -14.46645 43.77314  1.000 20.92555 ?  58  LYS A CB  1 
ATOM   467  C  CG  . LYS A 1 58  ? 30.27727  -15.40289 42.74068  1.000 25.04251 ?  58  LYS A CG  1 
ATOM   468  C  CD  . LYS A 1 58  ? 30.48308  -16.81691 43.27416  1.000 35.98380 ?  58  LYS A CD  1 
ATOM   469  C  CE  . LYS A 1 58  ? 29.42851  -17.78816 42.75399  1.000 41.33318 ?  58  LYS A CE  1 
ATOM   470  N  NZ  . LYS A 1 58  ? 29.61461  -19.18717 43.27185  1.000 42.31380 ?  58  LYS A NZ  1 
ATOM   471  N  N   . ARG A 1 59  ? 30.45974  -12.34340 41.16031  1.000 15.18244 ?  59  ARG A N   1 
ATOM   472  C  CA  . ARG A 1 59  ? 30.22840  -12.07758 39.74641  1.000 14.97636 ?  59  ARG A CA  1 
ATOM   473  C  C   . ARG A 1 59  ? 29.93263  -13.39319 39.03967  1.000 24.27119 ?  59  ARG A C   1 
ATOM   474  O  O   . ARG A 1 59  ? 30.72757  -14.33424 39.11463  1.000 14.14840 ?  59  ARG A O   1 
ATOM   475  C  CB  . ARG A 1 59  ? 31.45068  -11.38013 39.13274  1.000 18.22645 ?  59  ARG A CB  1 
ATOM   476  C  CG  . ARG A 1 59  ? 31.28284  -10.86044 37.70226  1.000 23.44185 ?  59  ARG A CG  1 
ATOM   477  C  CD  . ARG A 1 59  ? 32.61971  -10.34192 37.13343  1.000 29.09577 ?  59  ARG A CD  1 
ATOM   478  N  NE  . ARG A 1 59  ? 32.99144  -9.01384  37.62076  1.000 35.80380 ?  59  ARG A NE  1 
ATOM   479  C  CZ  . ARG A 1 59  ? 32.98715  -7.90985  36.88096  1.000 28.01502 ?  59  ARG A CZ  1 
ATOM   480  N  NH1 . ARG A 1 59  ? 32.62517  -7.93121  35.60620  1.000 15.16020 ?  59  ARG A NH1 1 
ATOM   481  N  NH2 . ARG A 1 59  ? 33.35545  -6.75420  37.43386  1.000 26.17511 ?  59  ARG A NH2 1 
ATOM   482  N  N   . LEU A 1 60  ? 28.76841  -13.46599 38.37490  1.000 10.41164 ?  60  LEU A N   1 
ATOM   483  C  CA  . LEU A 1 60  ? 28.29851  -14.65619 37.69305  1.000 14.14442 ?  60  LEU A CA  1 
ATOM   484  C  C   . LEU A 1 60  ? 28.93585  -14.77364 36.31198  1.000 13.52963 ?  60  LEU A C   1 
ATOM   485  O  O   . LEU A 1 60  ? 29.32154  -13.76289 35.70977  1.000 11.18043 ?  60  LEU A O   1 
ATOM   486  C  CB  . LEU A 1 60  ? 26.77699  -14.60515 37.55314  1.000 13.12474 ?  60  LEU A CB  1 
ATOM   487  C  CG  . LEU A 1 60  ? 25.99305  -14.61532 38.86898  1.000 12.39280 ?  60  LEU A CG  1 
ATOM   488  C  CD1 . LEU A 1 60  ? 24.51227  -14.37886 38.61317  1.000 12.54814 ?  60  LEU A CD1 1 
ATOM   489  C  CD2 . LEU A 1 60  ? 26.21658  -15.97476 39.54980  1.000 15.95602 ?  60  LEU A CD2 1 
ATOM   490  N  N   . PRO A 1 61  ? 29.06863  -15.99427 35.79377  1.000 12.84132 ?  61  PRO A N   1 
ATOM   491  C  CA  . PRO A 1 61  ? 29.52011  -16.15568 34.40206  1.000 12.76163 ?  61  PRO A CA  1 
ATOM   492  C  C   . PRO A 1 61  ? 28.75652  -15.24267 33.44638  1.000 15.58420 ?  61  PRO A C   1 
ATOM   493  O  O   . PRO A 1 61  ? 27.52626  -15.14649 33.49074  1.000 15.01457 ?  61  PRO A O   1 
ATOM   494  C  CB  . PRO A 1 61  ? 29.25028  -17.63490 34.12008  1.000 16.55319 ?  61  PRO A CB  1 
ATOM   495  C  CG  . PRO A 1 61  ? 29.43935  -18.29866 35.46580  1.000 16.39121 ?  61  PRO A CG  1 
ATOM   496  C  CD  . PRO A 1 61  ? 28.94371  -17.28549 36.50070  1.000 13.71450 ?  61  PRO A CD  1 
ATOM   497  N  N   . HIS A 1 62  ? 29.49950  -14.55816 32.58319  1.000 12.33562 ?  62  HIS A N   1 
ATOM   498  C  CA  . HIS A 1 62  ? 28.90952  -13.53008 31.73872  1.000 14.60490 ?  62  HIS A CA  1 
ATOM   499  C  C   . HIS A 1 62  ? 27.92765  -14.13815 30.75057  1.000 19.56256 ?  62  HIS A C   1 
ATOM   500  O  O   . HIS A 1 62  ? 28.24819  -15.10074 30.05395  1.000 18.59158 ?  62  HIS A O   1 
ATOM   501  C  CB  . HIS A 1 62  ? 30.00635  -12.78230 30.99123  1.000 20.17503 ?  62  HIS A CB  1 
ATOM   502  C  CG  . HIS A 1 62  ? 29.50595  -11.61635 30.20302  1.000 16.07103 ?  62  HIS A CG  1 
ATOM   503  N  ND1 . HIS A 1 62  ? 28.99114  -10.48427 30.79859  1.000 19.92341 ?  62  HIS A ND1 1 
ATOM   504  C  CD2 . HIS A 1 62  ? 29.43843  -11.40586 28.86750  1.000 16.69146 ?  62  HIS A CD2 1 
ATOM   505  C  CE1 . HIS A 1 62  ? 28.62514  -9.62728  29.86164  1.000 16.40060 ?  62  HIS A CE1 1 
ATOM   506  N  NE2 . HIS A 1 62  ? 28.88174  -10.16532 28.68139  1.000 20.03319 ?  62  HIS A NE2 1 
ATOM   507  N  N   . ARG A 1 63  ? 26.72781  -13.56248 30.67924  1.000 14.43838 ?  63  ARG A N   1 
ATOM   508  C  CA  . ARG A 1 63  ? 25.67325  -14.04959 29.79833  1.000 14.64878 ?  63  ARG A CA  1 
ATOM   509  C  C   . ARG A 1 63  ? 24.99062  -12.86799 29.11761  1.000 14.91082 ?  63  ARG A C   1 
ATOM   510  O  O   . ARG A 1 63  ? 24.95187  -11.76247 29.66493  1.000 15.15176 ?  63  ARG A O   1 
ATOM   511  C  CB  . ARG A 1 63  ? 24.61837  -14.84371 30.57091  1.000 12.23977 ?  63  ARG A CB  1 
ATOM   512  C  CG  . ARG A 1 63  ? 25.02481  -16.25329 30.98454  1.000 16.40642 ?  63  ARG A CG  1 
ATOM   513  C  CD  . ARG A 1 63  ? 23.90163  -16.91002 31.77660  1.000 15.77865 ?  63  ARG A CD  1 
ATOM   514  N  NE  . ARG A 1 63  ? 22.79139  -17.34617 30.93903  1.000 17.74543 ?  63  ARG A NE  1 
ATOM   515  C  CZ  . ARG A 1 63  ? 22.68684  -18.56438 30.42339  1.000 18.59970 ?  63  ARG A CZ  1 
ATOM   516  N  NH1 . ARG A 1 63  ? 23.65922  -19.45367 30.55163  1.000 12.61404 ?  63  ARG A NH1 1 
ATOM   517  N  NH2 . ARG A 1 63  ? 21.57654  -18.90084 29.77685  1.000 21.46847 ?  63  ARG A NH2 1 
ATOM   518  N  N   . ASP A 1 64  ? 24.44707  -13.10887 27.92299  1.000 15.09531 ?  64  ASP A N   1 
ATOM   519  C  CA  . ASP A 1 64  ? 23.60122  -12.10692 27.27945  1.000 14.61530 ?  64  ASP A CA  1 
ATOM   520  C  C   . ASP A 1 64  ? 22.51081  -11.63377 28.22997  1.000 11.90270 ?  64  ASP A C   1 
ATOM   521  O  O   . ASP A 1 64  ? 21.99537  -12.40678 29.03720  1.000 14.42999 ?  64  ASP A O   1 
ATOM   522  C  CB  . ASP A 1 64  ? 22.93475  -12.65460 26.02689  1.000 11.96826 ?  64  ASP A CB  1 
ATOM   523  C  CG  . ASP A 1 64  ? 23.91362  -13.19471 25.03699  1.000 19.64952 ?  64  ASP A CG  1 
ATOM   524  O  OD1 . ASP A 1 64  ? 25.12344  -12.85807 25.12975  1.000 18.74841 ?  64  ASP A OD1 1 
ATOM   525  O  OD2 . ASP A 1 64  ? 23.46174  -13.95796 24.16388  1.000 21.76194 -1 64  ASP A OD2 1 
ATOM   526  N  N   . TYR A 1 65  ? 22.15309  -10.35581 28.11188  1.000 9.13271  ?  65  TYR A N   1 
ATOM   527  C  CA  . TYR A 1 65  ? 21.03871  -9.79832  28.86217  1.000 10.87695 ?  65  TYR A CA  1 
ATOM   528  C  C   . TYR A 1 65  ? 19.73927  -10.11648 28.13704  1.000 12.06422 ?  65  TYR A C   1 
ATOM   529  O  O   . TYR A 1 65  ? 19.63985  -9.96314  26.91522  1.000 10.48446 ?  65  TYR A O   1 
ATOM   530  C  CB  . TYR A 1 65  ? 21.21514  -8.28479  29.02160  1.000 8.07318  ?  65  TYR A CB  1 
ATOM   531  C  CG  . TYR A 1 65  ? 20.01147  -7.53050  29.57318  1.000 10.24244 ?  65  TYR A CG  1 
ATOM   532  C  CD1 . TYR A 1 65  ? 19.45384  -7.85533  30.80650  1.000 8.53188  ?  65  TYR A CD1 1 
ATOM   533  C  CD2 . TYR A 1 65  ? 19.47602  -6.44347  28.87788  1.000 11.94020 ?  65  TYR A CD2 1 
ATOM   534  C  CE1 . TYR A 1 65  ? 18.36691  -7.13469  31.31650  1.000 11.57757 ?  65  TYR A CE1 1 
ATOM   535  C  CE2 . TYR A 1 65  ? 18.40151  -5.73408  29.37109  1.000 13.29506 ?  65  TYR A CE2 1 
ATOM   536  C  CZ  . TYR A 1 65  ? 17.85439  -6.07593  30.59758  1.000 12.05504 ?  65  TYR A CZ  1 
ATOM   537  O  OH  . TYR A 1 65  ? 16.78598  -5.33982  31.07236  1.000 14.17462 ?  65  TYR A OH  1 
ATOM   538  N  N   . THR A 1 66  ? 18.75098  -10.58182 28.88430  1.000 9.88007  ?  66  THR A N   1 
ATOM   539  C  CA  . THR A 1 66  ? 17.41954  -10.79276 28.33919  1.000 11.15647 ?  66  THR A CA  1 
ATOM   540  C  C   . THR A 1 66  ? 16.40027  -10.22018 29.30394  1.000 10.62441 ?  66  THR A C   1 
ATOM   541  O  O   . THR A 1 66  ? 16.51538  -10.40333 30.52494  1.000 11.14430 ?  66  THR A O   1 
ATOM   542  C  CB  . THR A 1 66  ? 17.12179  -12.27501 28.14563  1.000 11.27289 ?  66  THR A CB  1 
ATOM   543  O  OG1 . THR A 1 66  ? 17.22134  -12.91030 29.42271  1.000 12.95106 ?  66  THR A OG1 1 
ATOM   544  C  CG2 . THR A 1 66  ? 18.11205  -12.90230 27.19642  1.000 13.28097 ?  66  THR A CG2 1 
ATOM   545  N  N   . THR A 1 67  ? 15.39837  -9.54304  28.75589  1.000 9.70889  ?  67  THR A N   1 
ATOM   546  C  CA  . THR A 1 67  ? 14.29350  -9.05009  29.55932  1.000 11.64445 ?  67  THR A CA  1 
ATOM   547  C  C   . THR A 1 67  ? 13.01011  -9.32525  28.78913  1.000 13.04924 ?  67  THR A C   1 
ATOM   548  O  O   . THR A 1 67  ? 13.03679  -9.75886  27.63257  1.000 14.78115 ?  67  THR A O   1 
ATOM   549  C  CB  . THR A 1 67  ? 14.45931  -7.56639  29.92811  1.000 8.81664  ?  67  THR A CB  1 
ATOM   550  O  OG1 . THR A 1 67  ? 13.35924  -7.16502  30.74306  1.000 12.64627 ?  67  THR A OG1 1 
ATOM   551  C  CG2 . THR A 1 67  ? 14.48993  -6.66838  28.69502  1.000 10.97206 ?  67  THR A CG2 1 
ATOM   552  N  N   . TYR A 1 68  ? 11.88261  -9.11331  29.45452  1.000 12.11552 ?  68  TYR A N   1 
ATOM   553  C  CA  . TYR A 1 68  ? 10.58273  -9.42162  28.87966  1.000 12.88785 ?  68  TYR A CA  1 
ATOM   554  C  C   . TYR A 1 68  ? 10.00850  -8.22515  28.14068  1.000 14.33073 ?  68  TYR A C   1 
ATOM   555  O  O   . TYR A 1 68  ? 10.08592  -7.09210  28.62461  1.000 12.09463 ?  68  TYR A O   1 
ATOM   556  C  CB  . TYR A 1 68  ? 9.58848   -9.82812  29.96023  1.000 16.12795 ?  68  TYR A CB  1 
ATOM   557  C  CG  . TYR A 1 68  ? 9.91975   -11.05024 30.78955  1.000 15.15111 ?  68  TYR A CG  1 
ATOM   558  C  CD1 . TYR A 1 68  ? 10.87561  -10.99945 31.80235  1.000 13.53451 ?  68  TYR A CD1 1 
ATOM   559  C  CD2 . TYR A 1 68  ? 9.22955   -12.24321 30.59327  1.000 15.69576 ?  68  TYR A CD2 1 
ATOM   560  C  CE1 . TYR A 1 68  ? 11.15398  -12.12519 32.59232  1.000 11.99280 ?  68  TYR A CE1 1 
ATOM   561  C  CE2 . TYR A 1 68  ? 9.49315   -13.36631 31.36392  1.000 16.37189 ?  68  TYR A CE2 1 
ATOM   562  C  CZ  . TYR A 1 68  ? 10.44763  -13.30642 32.35943  1.000 16.29588 ?  68  TYR A CZ  1 
ATOM   563  O  OH  . TYR A 1 68  ? 10.68403  -14.43386 33.11660  1.000 11.81353 ?  68  TYR A OH  1 
ATOM   564  N  N   . LYS A 1 69  ? 9.38238   -8.49639  26.98859  1.000 11.78566 ?  69  LYS A N   1 
ATOM   565  C  CA  . LYS A 1 69  ? 8.62967   -7.46042  26.28245  1.000 19.52334 ?  69  LYS A CA  1 
ATOM   566  C  C   . LYS A 1 69  ? 7.53452   -6.86029  27.15117  1.000 12.80410 ?  69  LYS A C   1 
ATOM   567  O  O   . LYS A 1 69  ? 7.22532   -5.67087  27.01805  1.000 14.37235 ?  69  LYS A O   1 
ATOM   568  C  CB  . LYS A 1 69  ? 8.02670   -8.02000  24.99207  1.000 17.49526 ?  69  LYS A CB  1 
ATOM   569  C  CG  . LYS A 1 69  ? 9.06100   -8.25847  23.91120  1.000 20.31299 ?  69  LYS A CG  1 
ATOM   570  C  CD  . LYS A 1 69  ? 8.42820   -8.40670  22.52466  1.000 27.85370 ?  69  LYS A CD  1 
ATOM   571  C  CE  . LYS A 1 69  ? 9.50889   -8.50008  21.44053  1.000 33.15756 ?  69  LYS A CE  1 
ATOM   572  N  NZ  . LYS A 1 69  ? 8.97787   -8.44359  20.04212  1.000 34.07281 ?  69  LYS A NZ  1 
ATOM   573  N  N   . LYS A 1 70  ? 6.95368   -7.64396  28.06281  1.000 16.35455 ?  70  LYS A N   1 
ATOM   574  C  CA  . LYS A 1 70  ? 5.92253   -7.08849  28.93508  1.000 18.91486 ?  70  LYS A CA  1 
ATOM   575  C  C   . LYS A 1 70  ? 6.45313   -5.95844  29.80789  1.000 22.62885 ?  70  LYS A C   1 
ATOM   576  O  O   . LYS A 1 70  ? 5.67393   -5.08793  30.20848  1.000 18.20657 ?  70  LYS A O   1 
ATOM   577  C  CB  . LYS A 1 70  ? 5.29263   -8.18266  29.81037  1.000 23.89790 ?  70  LYS A CB  1 
ATOM   578  C  CG  . LYS A 1 70  ? 6.17654   -8.69183  30.92733  1.000 21.81588 ?  70  LYS A CG  1 
ATOM   579  C  CD  . LYS A 1 70  ? 5.42312   -9.60660  31.88528  1.000 29.77792 ?  70  LYS A CD  1 
ATOM   580  C  CE  . LYS A 1 70  ? 5.17620   -10.96764 31.27866  1.000 30.12569 ?  70  LYS A CE  1 
ATOM   581  N  NZ  . LYS A 1 70  ? 5.52532   -12.08346 32.22350  1.000 35.92732 ?  70  LYS A NZ  1 
ATOM   582  N  N   . PHE A 1 71  ? 7.75647   -5.93901  30.10332  1.000 19.23016 ?  71  PHE A N   1 
ATOM   583  C  CA  . PHE A 1 71  ? 8.35370   -4.85912  30.87980  1.000 15.16508 ?  71  PHE A CA  1 
ATOM   584  C  C   . PHE A 1 71  ? 9.07177   -3.84111  30.01419  1.000 18.33649 ?  71  PHE A C   1 
ATOM   585  O  O   . PHE A 1 71  ? 9.05489   -2.64837  30.31758  1.000 17.80870 ?  71  PHE A O   1 
ATOM   586  C  CB  . PHE A 1 71  ? 9.34283   -5.42046  31.90715  1.000 14.56239 ?  71  PHE A CB  1 
ATOM   587  C  CG  . PHE A 1 71  ? 8.74118   -6.42388  32.81785  1.000 15.35057 ?  71  PHE A CG  1 
ATOM   588  C  CD1 . PHE A 1 71  ? 7.62464   -6.10851  33.56775  1.000 15.17823 ?  71  PHE A CD1 1 
ATOM   589  C  CD2 . PHE A 1 71  ? 9.28340   -7.68904  32.93298  1.000 15.70594 ?  71  PHE A CD2 1 
ATOM   590  C  CE1 . PHE A 1 71  ? 7.06209   -7.03669  34.40550  1.000 14.70382 ?  71  PHE A CE1 1 
ATOM   591  C  CE2 . PHE A 1 71  ? 8.71447   -8.62453  33.77458  1.000 15.55978 ?  71  PHE A CE2 1 
ATOM   592  C  CZ  . PHE A 1 71  ? 7.60872   -8.29838  34.50793  1.000 14.56527 ?  71  PHE A CZ  1 
ATOM   593  N  N   . ASN A 1 72  ? 9.71651   -4.28019  28.94413  1.000 12.41058 ?  72  ASN A N   1 
ATOM   594  C  CA  . ASN A 1 72  ? 10.45709  -3.38962  28.05907  1.000 14.27624 ?  72  ASN A CA  1 
ATOM   595  C  C   . ASN A 1 72  ? 10.03898  -3.77427  26.64788  1.000 13.51181 ?  72  ASN A C   1 
ATOM   596  O  O   . ASN A 1 72  ? 10.60403  -4.70473  26.05699  1.000 15.05528 ?  72  ASN A O   1 
ATOM   597  C  CB  . ASN A 1 72  ? 11.96245  -3.52431  28.27442  1.000 15.57383 ?  72  ASN A CB  1 
ATOM   598  C  CG  . ASN A 1 72  ? 12.77729  -2.61369  27.36093  1.000 20.31971 ?  72  ASN A CG  1 
ATOM   599  O  OD1 . ASN A 1 72  ? 12.22992  -1.89858  26.51644  1.000 16.56255 ?  72  ASN A OD1 1 
ATOM   600  N  ND2 . ASN A 1 72  ? 14.09535  -2.62454  27.54327  1.000 19.72610 ?  72  ASN A ND2 1 
ATOM   601  N  N   . PRO A 1 73  ? 9.03763   -3.09202  26.08249  1.000 15.24029 ?  73  PRO A N   1 
ATOM   602  C  CA  . PRO A 1 73  ? 8.57404   -3.46022  24.73520  1.000 18.94718 ?  73  PRO A CA  1 
ATOM   603  C  C   . PRO A 1 73  ? 9.56203   -3.10435  23.64876  1.000 18.93001 ?  73  PRO A C   1 
ATOM   604  O  O   . PRO A 1 73  ? 9.52440   -3.72243  22.58025  1.000 19.89676 ?  73  PRO A O   1 
ATOM   605  C  CB  . PRO A 1 73  ? 7.25961   -2.67972  24.58039  1.000 18.50516 ?  73  PRO A CB  1 
ATOM   606  C  CG  . PRO A 1 73  ? 7.34059   -1.58355  25.57475  1.000 25.88033 ?  73  PRO A CG  1 
ATOM   607  C  CD  . PRO A 1 73  ? 8.13812   -2.12679  26.73217  1.000 17.17456 ?  73  PRO A CD  1 
ATOM   608  N  N   . VAL A 1 74  ? 10.47483  -2.16638  23.90136  1.000 13.90987 ?  74  VAL A N   1 
ATOM   609  C  CA  . VAL A 1 74  ? 11.42166  -1.76087  22.87349  1.000 16.68642 ?  74  VAL A CA  1 
ATOM   610  C  C   . VAL A 1 74  ? 12.64596  -2.67919  22.86090  1.000 18.77005 ?  74  VAL A C   1 
ATOM   611  O  O   . VAL A 1 74  ? 13.20688  -2.97079  21.80081  1.000 17.90524 ?  74  VAL A O   1 
ATOM   612  C  CB  . VAL A 1 74  ? 11.80436  -0.28323  23.09761  1.000 17.32558 ?  74  VAL A CB  1 
ATOM   613  C  CG1 . VAL A 1 74  ? 12.83836  0.14800   22.11008  1.000 21.93678 ?  74  VAL A CG1 1 
ATOM   614  C  CG2 . VAL A 1 74  ? 10.58873  0.57653   22.97111  1.000 15.49846 ?  74  VAL A CG2 1 
ATOM   615  N  N   . GLY A 1 75  ? 13.09833  -3.13061  24.02537  1.000 14.64008 ?  75  GLY A N   1 
ATOM   616  C  CA  . GLY A 1 75  ? 14.29480  -3.94812  24.07875  1.000 16.64300 ?  75  GLY A CA  1 
ATOM   617  C  C   . GLY A 1 75  ? 14.10198  -5.31727  24.70875  1.000 12.72930 ?  75  GLY A C   1 
ATOM   618  O  O   . GLY A 1 75  ? 15.08153  -5.98371  25.05696  1.000 13.46777 ?  75  GLY A O   1 
ATOM   619  N  N   . GLY A 1 76  ? 12.84044  -5.74771  24.87061  1.000 9.02732  ?  76  GLY A N   1 
ATOM   620  C  CA  . GLY A 1 76  ? 12.55968  -7.02230  25.49963  1.000 11.49425 ?  76  GLY A CA  1 
ATOM   621  C  C   . GLY A 1 76  ? 12.51468  -8.17221  24.50442  1.000 15.10539 ?  76  GLY A C   1 
ATOM   622  O  O   . GLY A 1 76  ? 12.44255  -7.96733  23.29086  1.000 15.34730 ?  76  GLY A O   1 
ATOM   623  N  N   . GLY A 1 77  ? 12.60198  -9.38645  25.04842  1.000 12.59032 ?  77  GLY A N   1 
ATOM   624  C  CA  . GLY A 1 77  ? 12.39479  -10.58460 24.25687  1.000 16.19418 ?  77  GLY A CA  1 
ATOM   625  C  C   . GLY A 1 77  ? 13.50443  -10.94731 23.29827  1.000 18.97039 ?  77  GLY A C   1 
ATOM   626  O  O   . GLY A 1 77  ? 13.29404  -11.81044 22.43723  1.000 17.08885 ?  77  GLY A O   1 
ATOM   627  N  N   . ILE A 1 78  ? 14.68196  -10.32723 23.41288  1.000 14.00985 ?  78  ILE A N   1 
ATOM   628  C  CA  . ILE A 1 78  ? 15.83018  -10.66587 22.57541  1.000 17.98050 ?  78  ILE A CA  1 
ATOM   629  C  C   . ILE A 1 78  ? 17.07965  -10.83610 23.43711  1.000 15.74762 ?  78  ILE A C   1 
ATOM   630  O  O   . ILE A 1 78  ? 17.18437  -10.29451 24.54246  1.000 14.24057 ?  78  ILE A O   1 
ATOM   631  C  CB  . ILE A 1 78  ? 16.09662  -9.61381  21.46711  1.000 17.63440 ?  78  ILE A CB  1 
ATOM   632  C  CG1 . ILE A 1 78  ? 16.21470  -8.21141  22.06755  1.000 15.26989 ?  78  ILE A CG1 1 
ATOM   633  C  CG2 . ILE A 1 78  ? 14.99548  -9.63473  20.42603  1.000 22.62670 ?  78  ILE A CG2 1 
ATOM   634  C  CD1 . ILE A 1 78  ? 16.85374  -7.21923  21.13492  1.000 17.35026 ?  78  ILE A CD1 1 
ATOM   635  N  N   . ARG A 1 79  ? 18.04056  -11.59338 22.90589  1.000 12.79591 ?  79  ARG A N   1 
ATOM   636  C  CA  . ARG A 1 79  ? 19.34634  -11.75211 23.53243  1.000 15.58960 ?  79  ARG A CA  1 
ATOM   637  C  C   . ARG A 1 79  ? 20.15940  -10.50383 23.23112  1.000 15.19884 ?  79  ARG A C   1 
ATOM   638  O  O   . ARG A 1 79  ? 20.32159  -10.12693 22.06923  1.000 10.44058 ?  79  ARG A O   1 
ATOM   639  C  CB  . ARG A 1 79  ? 20.05397  -13.00756 23.01182  1.000 16.22406 ?  79  ARG A CB  1 
ATOM   640  C  CG  . ARG A 1 79  ? 19.33068  -14.33307 23.37698  1.000 19.50797 ?  79  ARG A CG  1 
ATOM   641  C  CD  . ARG A 1 79  ? 20.21166  -15.57614 23.14816  1.000 30.92456 ?  79  ARG A CD  1 
ATOM   642  N  NE  . ARG A 1 79  ? 19.70519  -16.75481 23.85644  1.000 30.55036 ?  79  ARG A NE  1 
ATOM   643  C  CZ  . ARG A 1 79  ? 18.82728  -17.61336 23.35065  1.000 42.75885 ?  79  ARG A CZ  1 
ATOM   644  N  NH1 . ARG A 1 79  ? 18.33012  -17.46011 22.13302  1.000 39.76090 ?  79  ARG A NH1 1 
ATOM   645  N  NH2 . ARG A 1 79  ? 18.43221  -18.64875 24.08644  1.000 44.16380 ?  79  ARG A NH2 1 
ATOM   646  N  N   . ARG A 1 80  ? 20.63338  -9.83788  24.25882  1.000 10.41119 ?  80  ARG A N   1 
ATOM   647  C  CA  . ARG A 1 80  ? 21.37916  -8.60706  24.06827  1.000 9.21202  ?  80  ARG A CA  1 
ATOM   648  C  C   . ARG A 1 80  ? 22.80676  -8.86427  24.52706  1.000 12.30077 ?  80  ARG A C   1 
ATOM   649  O  O   . ARG A 1 80  ? 23.06060  -9.07049  25.72042  1.000 10.59829 ?  80  ARG A O   1 
ATOM   650  C  CB  . ARG A 1 80  ? 20.70170  -7.45161  24.80092  1.000 10.26034 ?  80  ARG A CB  1 
ATOM   651  C  CG  . ARG A 1 80  ? 19.38493  -7.08143  24.12516  1.000 13.58737 ?  80  ARG A CG  1 
ATOM   652  C  CD  . ARG A 1 80  ? 18.44606  -6.28193  25.00649  1.000 12.27590 ?  80  ARG A CD  1 
ATOM   653  N  NE  . ARG A 1 80  ? 19.02734  -5.01092  25.42040  1.000 9.65628  ?  80  ARG A NE  1 
ATOM   654  C  CZ  . ARG A 1 80  ? 18.39540  -4.12104  26.17579  1.000 15.92448 ?  80  ARG A CZ  1 
ATOM   655  N  NH1 . ARG A 1 80  ? 17.14417  -4.30469  26.55016  1.000 11.74084 ?  80  ARG A NH1 1 
ATOM   656  N  NH2 . ARG A 1 80  ? 19.03974  -3.02809  26.57450  1.000 11.00190 ?  80  ARG A NH2 1 
ATOM   657  N  N   . VAL A 1 81  ? 23.71891  -8.87633  23.56324  1.000 10.67458 ?  81  VAL A N   1 
ATOM   658  C  CA  . VAL A 1 81  ? 25.10681  -9.26915  23.77406  1.000 16.69776 ?  81  VAL A CA  1 
ATOM   659  C  C   . VAL A 1 81  ? 25.86831  -8.01426  24.15672  1.000 14.55293 ?  81  VAL A C   1 
ATOM   660  O  O   . VAL A 1 81  ? 26.09091  -7.13621  23.32074  1.000 13.82749 ?  81  VAL A O   1 
ATOM   661  C  CB  . VAL A 1 81  ? 25.69695  -9.91593  22.51658  1.000 16.62869 ?  81  VAL A CB  1 
ATOM   662  C  CG1 . VAL A 1 81  ? 27.16640  -10.29113 22.74106  1.000 18.64239 ?  81  VAL A CG1 1 
ATOM   663  C  CG2 . VAL A 1 81  ? 24.86246  -11.12324 22.12523  1.000 16.36449 ?  81  VAL A CG2 1 
ATOM   664  N  N   . TYR A 1 82  ? 26.22308  -7.91366  25.43088  1.000 12.76347 ?  82  TYR A N   1 
ATOM   665  C  CA  . TYR A 1 82  ? 26.98395  -6.79975  25.95782  1.000 16.45984 ?  82  TYR A CA  1 
ATOM   666  C  C   . TYR A 1 82  ? 28.32306  -7.30098  26.48060  1.000 17.43254 ?  82  TYR A C   1 
ATOM   667  O  O   . TYR A 1 82  ? 28.52442  -8.50164  26.69228  1.000 14.03072 ?  82  TYR A O   1 
ATOM   668  C  CB  . TYR A 1 82  ? 26.19746  -6.09417  27.06789  1.000 13.06188 ?  82  TYR A CB  1 
ATOM   669  C  CG  . TYR A 1 82  ? 24.96202  -5.40918  26.54393  1.000 12.43537 ?  82  TYR A CG  1 
ATOM   670  C  CD1 . TYR A 1 82  ? 25.04554  -4.50464  25.48777  1.000 14.96036 ?  82  TYR A CD1 1 
ATOM   671  C  CD2 . TYR A 1 82  ? 23.71325  -5.66073  27.09587  1.000 11.15287 ?  82  TYR A CD2 1 
ATOM   672  C  CE1 . TYR A 1 82  ? 23.92227  -3.86123  25.00809  1.000 12.55625 ?  82  TYR A CE1 1 
ATOM   673  C  CE2 . TYR A 1 82  ? 22.59359  -5.02413  26.62021  1.000 14.04267 ?  82  TYR A CE2 1 
ATOM   674  C  CZ  . TYR A 1 82  ? 22.69977  -4.12548  25.57594  1.000 13.88529 ?  82  TYR A CZ  1 
ATOM   675  O  OH  . TYR A 1 82  ? 21.57292  -3.49143  25.08863  1.000 8.80856  ?  82  TYR A OH  1 
ATOM   676  N  N   . GLU A 1 83  ? 29.19631  -6.40796  26.66607  1.000 15.34483 ?  83  GLU A N   1 
ATOM   677  C  CA  . GLU A 1 83  ? 30.47536  -6.72997  27.27348  1.000 16.50721 ?  83  GLU A CA  1 
ATOM   678  C  C   . GLU A 1 83  ? 30.41719  -6.54288  28.79043  1.000 16.53928 ?  83  GLU A C   1 
ATOM   679  O  O   . GLU A 1 83  ? 29.61765  -5.74670  29.29594  1.000 13.14620 ?  83  GLU A O   1 
ATOM   680  C  CB  . GLU A 1 83  ? 31.56860  -5.85960  26.66564  1.000 15.62123 ?  83  GLU A CB  1 
ATOM   681  C  CG  . GLU A 1 83  ? 31.71004  -6.12822  25.16067  1.000 23.77288 ?  83  GLU A CG  1 
ATOM   682  C  CD  . GLU A 1 83  ? 32.75463  -5.25711  24.47464  1.000 32.68768 ?  83  GLU A CD  1 
ATOM   683  O  OE1 . GLU A 1 83  ? 33.56076  -4.60986  25.17468  1.000 32.23904 ?  83  GLU A OE1 1 
ATOM   684  O  OE2 . GLU A 1 83  ? 32.76815  -5.22058  23.22419  1.000 37.37580 -1 83  GLU A OE2 1 
ATOM   685  N  N   . PRO A 1 84  ? 31.22625  -7.28166  29.54571  1.000 14.26507 ?  84  PRO A N   1 
ATOM   686  C  CA  . PRO A 1 84  ? 31.17029  -7.17229  31.00797  1.000 13.19848 ?  84  PRO A CA  1 
ATOM   687  C  C   . PRO A 1 84  ? 31.63238  -5.81116  31.49710  1.000 13.98052 ?  84  PRO A C   1 
ATOM   688  O  O   . PRO A 1 84  ? 32.38373  -5.09261  30.83424  1.000 11.43217 ?  84  PRO A O   1 
ATOM   689  C  CB  . PRO A 1 84  ? 32.12108  -8.27746  31.49046  1.000 15.15271 ?  84  PRO A CB  1 
ATOM   690  C  CG  . PRO A 1 84  ? 33.02900  -8.52590  30.31741  1.000 16.64859 ?  84  PRO A CG  1 
ATOM   691  C  CD  . PRO A 1 84  ? 32.18101  -8.31802  29.10580  1.000 12.10360 ?  84  PRO A CD  1 
ATOM   692  N  N   . ILE A 1 85  ? 31.16126  -5.47050  32.69636  1.000 9.14382  ?  85  ILE A N   1 
ATOM   693  C  CA  . ILE A 1 85  ? 31.60230  -4.26460  33.38082  1.000 8.70637  ?  85  ILE A CA  1 
ATOM   694  C  C   . ILE A 1 85  ? 33.03664  -4.47916  33.84881  1.000 12.86178 ?  85  ILE A C   1 
ATOM   695  O  O   . ILE A 1 85  ? 33.39145  -5.56864  34.31038  1.000 12.95054 ?  85  ILE A O   1 
ATOM   696  C  CB  . ILE A 1 85  ? 30.65650  -3.96291  34.55268  1.000 12.49361 ?  85  ILE A CB  1 
ATOM   697  C  CG1 . ILE A 1 85  ? 29.27298  -3.55507  34.01587  1.000 8.17818  ?  85  ILE A CG1 1 
ATOM   698  C  CG2 . ILE A 1 85  ? 31.22566  -2.93091  35.50564  1.000 9.15588  ?  85  ILE A CG2 1 
ATOM   699  C  CD1 . ILE A 1 85  ? 28.24384  -3.38806  35.09004  1.000 10.59142 ?  85  ILE A CD1 1 
ATOM   700  N  N   . GLU A 1 86  ? 33.87288  -3.45574  33.70143  1.000 11.11598 ?  86  GLU A N   1 
ATOM   701  C  CA  . GLU A 1 86  ? 35.27758  -3.60319  34.07833  1.000 14.67180 ?  86  GLU A CA  1 
ATOM   702  C  C   . GLU A 1 86  ? 35.48875  -3.28963  35.55105  1.000 14.72685 ?  86  GLU A C   1 
ATOM   703  O  O   . GLU A 1 86  ? 36.17787  -4.02928  36.25562  1.000 17.15446 ?  86  GLU A O   1 
ATOM   704  C  CB  . GLU A 1 86  ? 36.14782  -2.69839  33.21011  1.000 12.97288 ?  86  GLU A CB  1 
ATOM   705  C  CG  . GLU A 1 86  ? 36.12413  -3.09013  31.74181  1.000 17.87375 ?  86  GLU A CG  1 
ATOM   706  C  CD  . GLU A 1 86  ? 37.01560  -2.21167  30.86742  1.000 28.67808 ?  86  GLU A CD  1 
ATOM   707  O  OE1 . GLU A 1 86  ? 36.74281  -0.99212  30.73221  1.000 20.60720 ?  86  GLU A OE1 1 
ATOM   708  O  OE2 . GLU A 1 86  ? 37.99194  -2.75049  30.30894  1.000 36.77993 -1 86  GLU A OE2 1 
ATOM   709  N  N   . VAL A 1 87  ? 34.86137  -2.22466  36.03538  1.000 13.75093 ?  87  VAL A N   1 
ATOM   710  C  CA  . VAL A 1 87  ? 35.09930  -1.70146  37.36997  1.000 12.39988 ?  87  VAL A CA  1 
ATOM   711  C  C   . VAL A 1 87  ? 34.19726  -2.39780  38.37703  1.000 13.41347 ?  87  VAL A C   1 
ATOM   712  O  O   . VAL A 1 87  ? 33.41993  -3.28506  38.01712  1.000 12.56471 ?  87  VAL A O   1 
ATOM   713  C  CB  . VAL A 1 87  ? 34.89867  -0.17880  37.35742  1.000 12.76668 ?  87  VAL A CB  1 
ATOM   714  C  CG1 . VAL A 1 87  ? 35.86636  0.41412   36.35616  1.000 14.33330 ?  87  VAL A CG1 1 
ATOM   715  C  CG2 . VAL A 1 87  ? 33.47796  0.17515   36.94117  1.000 13.84192 ?  87  VAL A CG2 1 
ATOM   716  N  N   . ASP A 1 88  ? 34.27825  -1.99466  39.63384  1.000 10.60952 ?  88  ASP A N   1 
ATOM   717  C  CA  . ASP A 1 88  ? 33.61441  -2.69934  40.72241  1.000 14.24649 ?  88  ASP A CA  1 
ATOM   718  C  C   . ASP A 1 88  ? 32.62110  -1.74202  41.36843  1.000 12.38052 ?  88  ASP A C   1 
ATOM   719  O  O   . ASP A 1 88  ? 32.98263  -0.91025  42.20718  1.000 9.32182  ?  88  ASP A O   1 
ATOM   720  C  CB  . ASP A 1 88  ? 34.62930  -3.22284  41.72868  1.000 14.49967 ?  88  ASP A CB  1 
ATOM   721  C  CG  . ASP A 1 88  ? 33.98368  -3.71215  43.01052  1.000 18.99380 ?  88  ASP A CG  1 
ATOM   722  O  OD1 . ASP A 1 88  ? 32.74945  -3.97655  43.04754  1.000 18.87556 -1 88  ASP A OD1 1 
ATOM   723  O  OD2 . ASP A 1 88  ? 34.73256  -3.80889  43.99788  1.000 19.85241 ?  88  ASP A OD2 1 
ATOM   724  N  N   . PHE A 1 89  ? 31.36567  -1.87336  40.97316  1.000 10.24805 ?  89  PHE A N   1 
ATOM   725  C  CA  . PHE A 1 89  ? 30.28133  -1.07729  41.52817  1.000 13.07313 ?  89  PHE A CA  1 
ATOM   726  C  C   . PHE A 1 89  ? 29.76786  -1.60502  42.85835  1.000 13.19707 ?  89  PHE A C   1 
ATOM   727  O  O   . PHE A 1 89  ? 28.82104  -1.02220  43.41454  1.000 10.02801 ?  89  PHE A O   1 
ATOM   728  C  CB  . PHE A 1 89  ? 29.13406  -1.02643  40.51806  1.000 6.59380  ?  89  PHE A CB  1 
ATOM   729  C  CG  . PHE A 1 89  ? 29.39596  -0.11155  39.37897  1.000 6.01066  ?  89  PHE A CG  1 
ATOM   730  C  CD1 . PHE A 1 89  ? 29.40947  1.27118   39.58350  1.000 6.66853  ?  89  PHE A CD1 1 
ATOM   731  C  CD2 . PHE A 1 89  ? 29.61037  -0.61009  38.10663  1.000 6.84200  ?  89  PHE A CD2 1 
ATOM   732  C  CE1 . PHE A 1 89  ? 29.64164  2.14441   38.53603  1.000 11.17249 ?  89  PHE A CE1 1 
ATOM   733  C  CE2 . PHE A 1 89  ? 29.84025  0.26487   37.03490  1.000 7.93632  ?  89  PHE A CE2 1 
ATOM   734  C  CZ  . PHE A 1 89  ? 29.85709  1.64639   37.26228  1.000 7.56829  ?  89  PHE A CZ  1 
ATOM   735  N  N   . THR A 1 90  ? 30.33860  -2.70047  43.36535  1.000 14.13334 ?  90  THR A N   1 
ATOM   736  C  CA  . THR A 1 90  ? 29.70899  -3.34249  44.50971  1.000 13.04135 ?  90  THR A CA  1 
ATOM   737  C  C   . THR A 1 90  ? 29.75498  -2.47142  45.77719  1.000 14.88711 ?  90  THR A C   1 
ATOM   738  O  O   . THR A 1 90  ? 28.77651  -2.48858  46.53415  1.000 19.04836 ?  90  THR A O   1 
ATOM   739  C  CB  . THR A 1 90  ? 30.28574  -4.75181  44.75425  1.000 14.91540 ?  90  THR A CB  1 
ATOM   740  O  OG1 . THR A 1 90  ? 31.61151  -4.68062  45.27825  1.000 13.24191 ?  90  THR A OG1 1 
ATOM   741  C  CG2 . THR A 1 90  ? 30.31058  -5.55630  43.44717  1.000 15.50883 ?  90  THR A CG2 1 
ATOM   742  N  N   . PRO A 1 91  ? 30.78690  -1.66307  46.05176  1.000 15.14954 ?  91  PRO A N   1 
ATOM   743  C  CA  . PRO A 1 91  ? 30.64244  -0.73400  47.19629  1.000 14.75750 ?  91  PRO A CA  1 
ATOM   744  C  C   . PRO A 1 91  ? 29.45467  0.21772   47.05774  1.000 16.14693 ?  91  PRO A C   1 
ATOM   745  O  O   . PRO A 1 91  ? 28.68284  0.40857   48.00592  1.000 14.52012 ?  91  PRO A O   1 
ATOM   746  C  CB  . PRO A 1 91  ? 31.98145  0.02034   47.22391  1.000 20.60500 ?  91  PRO A CB  1 
ATOM   747  C  CG  . PRO A 1 91  ? 32.74584  -0.41758  46.06903  1.000 18.19848 ?  91  PRO A CG  1 
ATOM   748  C  CD  . PRO A 1 91  ? 32.16930  -1.67562  45.54056  1.000 21.10543 ?  91  PRO A CD  1 
ATOM   749  N  N   . LEU A 1 92  ? 29.27716  0.81154   45.88459  1.000 14.47512 ?  92  LEU A N   1 
ATOM   750  C  CA  . LEU A 1 92  ? 28.12279  1.67187   45.64680  1.000 14.63814 ?  92  LEU A CA  1 
ATOM   751  C  C   . LEU A 1 92  ? 26.80879  0.89840   45.81778  1.000 11.28987 ?  92  LEU A C   1 
ATOM   752  O  O   . LEU A 1 92  ? 25.87718  1.37647   46.47594  1.000 15.46877 ?  92  LEU A O   1 
ATOM   753  C  CB  . LEU A 1 92  ? 28.26789  2.28251   44.24466  1.000 13.99892 ?  92  LEU A CB  1 
ATOM   754  C  CG  . LEU A 1 92  ? 27.30945  3.28056   43.60343  1.000 19.01738 ?  92  LEU A CG  1 
ATOM   755  C  CD1 . LEU A 1 92  ? 27.99395  4.05276   42.47025  1.000 15.85019 ?  92  LEU A CD1 1 
ATOM   756  C  CD2 . LEU A 1 92  ? 26.11545  2.54777   43.06456  1.000 16.63777 ?  92  LEU A CD2 1 
ATOM   757  N  N   . ILE A 1 93  ? 26.72998  -0.31155  45.26661  1.000 10.26311 ?  93  ILE A N   1 
ATOM   758  C  CA  . ILE A 1 93  ? 25.53677  -1.13989  45.42582  1.000 12.84192 ?  93  ILE A CA  1 
ATOM   759  C  C   . ILE A 1 93  ? 25.24721  -1.41320  46.89816  1.000 18.05027 ?  93  ILE A C   1 
ATOM   760  O  O   . ILE A 1 93  ? 24.08116  -1.45633  47.31354  1.000 20.29100 ?  93  ILE A O   1 
ATOM   761  C  CB  . ILE A 1 93  ? 25.69123  -2.44823  44.62759  1.000 11.43226 ?  93  ILE A CB  1 
ATOM   762  C  CG1 . ILE A 1 93  ? 25.69398  -2.14310  43.13054  1.000 9.50021  ?  93  ILE A CG1 1 
ATOM   763  C  CG2 . ILE A 1 93  ? 24.59674  -3.44985  44.96580  1.000 12.99166 ?  93  ILE A CG2 1 
ATOM   764  C  CD1 . ILE A 1 93  ? 26.12114  -3.34503  42.29398  1.000 12.81908 ?  93  ILE A CD1 1 
ATOM   765  N  N   . SER A 1 94  ? 26.29616  -1.61368  47.70580  1.000 14.71224 ?  94  SER A N   1 
ATOM   766  C  CA  . SER A 1 94  ? 26.10043  -1.90668  49.12113  1.000 16.43427 ?  94  SER A CA  1 
ATOM   767  C  C   . SER A 1 94  ? 25.38760  -0.77858  49.84149  1.000 13.66768 ?  94  SER A C   1 
ATOM   768  O  O   . SER A 1 94  ? 24.64476  -1.03608  50.79232  1.000 13.91131 ?  94  SER A O   1 
ATOM   769  C  CB  . SER A 1 94  ? 27.44171  -2.18823  49.80716  1.000 16.38084 ?  94  SER A CB  1 
ATOM   770  O  OG  . SER A 1 94  ? 27.93499  -3.41456  49.35588  1.000 17.92435 ?  94  SER A OG  1 
ATOM   771  N  N   . GLU A 1 95  ? 25.61925  0.47585   49.42904  1.000 17.06365 ?  95  GLU A N   1 
ATOM   772  C  CA  . GLU A 1 95  ? 24.83389  1.57878   49.97290  1.000 17.19963 ?  95  GLU A CA  1 
ATOM   773  C  C   . GLU A 1 95  ? 23.36297  1.36386   49.69289  1.000 19.06790 ?  95  GLU A C   1 
ATOM   774  O  O   . GLU A 1 95  ? 22.51904  1.62421   50.55567  1.000 22.81921 ?  95  GLU A O   1 
ATOM   775  C  CB  . GLU A 1 95  ? 25.28684  2.91858   49.39434  1.000 17.07131 ?  95  GLU A CB  1 
ATOM   776  C  CG  . GLU A 1 95  ? 26.72762  3.22914   49.65950  1.000 31.75380 ?  95  GLU A CG  1 
ATOM   777  C  CD  . GLU A 1 95  ? 26.99811  3.48059   51.13158  1.000 36.21929 ?  95  GLU A CD  1 
ATOM   778  O  OE1 . GLU A 1 95  ? 27.89981  2.82181   51.68801  1.000 36.57593 ?  95  GLU A OE1 1 
ATOM   779  O  OE2 . GLU A 1 95  ? 26.31020  4.33487   51.72731  1.000 62.85380 -1 95  GLU A OE2 1 
ATOM   780  N  N   . GLY A 1 96  ? 23.04221  0.85125   48.50213  1.000 19.21752 ?  96  GLY A N   1 
ATOM   781  C  CA  . GLY A 1 96  ? 21.66058  0.55533   48.18194  1.000 15.46435 ?  96  GLY A CA  1 
ATOM   782  C  C   . GLY A 1 96  ? 21.10952  -0.58362  49.01501  1.000 18.67857 ?  96  GLY A C   1 
ATOM   783  O  O   . GLY A 1 96  ? 19.99980  -0.49055  49.54399  1.000 21.22746 ?  96  GLY A O   1 
ATOM   784  N  N   . ILE A 1 97  ? 21.87336  -1.67382  49.14260  1.000 13.32079 ?  97  ILE A N   1 
ATOM   785  C  CA  . ILE A 1 97  ? 21.44404  -2.80376  49.96692  1.000 18.26384 ?  97  ILE A CA  1 
ATOM   786  C  C   . ILE A 1 97  ? 21.16512  -2.34697  51.39634  1.000 20.17640 ?  97  ILE A C   1 
ATOM   787  O  O   . ILE A 1 97  ? 20.14089  -2.70535  51.99631  1.000 17.07255 ?  97  ILE A O   1 
ATOM   788  C  CB  . ILE A 1 97  ? 22.51112  -3.91336  49.91756  1.000 19.65746 ?  97  ILE A CB  1 
ATOM   789  C  CG1 . ILE A 1 97  ? 22.63798  -4.44576  48.50055  1.000 16.89732 ?  97  ILE A CG1 1 
ATOM   790  C  CG2 . ILE A 1 97  ? 22.18988  -5.03113  50.87841  1.000 17.62410 ?  97  ILE A CG2 1 
ATOM   791  C  CD1 . ILE A 1 97  ? 23.72989  -5.45812  48.37404  1.000 23.03082 ?  97  ILE A CD1 1 
ATOM   792  N  N   . ARG A 1 98  ? 22.05238  -1.51780  51.94941  1.000 18.06200 ?  98  ARG A N   1 
ATOM   793  C  CA  . ARG A 1 98  ? 21.86719  -1.01952  53.31390  1.000 24.28949 ?  98  ARG A CA  1 
ATOM   794  C  C   . ARG A 1 98  ? 20.57558  -0.21991  53.43590  1.000 22.43287 ?  98  ARG A C   1 
ATOM   795  O  O   . ARG A 1 98  ? 19.77622  -0.43956  54.35263  1.000 17.36069 ?  98  ARG A O   1 
ATOM   796  C  CB  . ARG A 1 98  ? 23.07042  -0.16187  53.71341  1.000 25.04055 ?  98  ARG A CB  1 
ATOM   797  C  CG  . ARG A 1 98  ? 22.91596  0.62008   54.99511  1.000 23.47745 ?  98  ARG A CG  1 
ATOM   798  C  CD  . ARG A 1 98  ? 23.90412  1.81171   55.08089  1.000 36.69286 ?  98  ARG A CD  1 
ATOM   799  N  NE  . ARG A 1 98  ? 25.14431  1.62741   54.32588  1.000 45.77170 ?  98  ARG A NE  1 
ATOM   800  C  CZ  . ARG A 1 98  ? 26.20037  0.94563   54.75617  1.000 48.66237 ?  98  ARG A CZ  1 
ATOM   801  N  NH1 . ARG A 1 98  ? 26.21978  0.38365   55.95333  1.000 59.44666 ?  98  ARG A NH1 1 
ATOM   802  N  NH2 . ARG A 1 98  ? 27.26156  0.81894   53.96229  1.000 44.22903 ?  98  ARG A NH2 1 
ATOM   803  N  N   . GLU A 1 99  ? 20.33716  0.68159   52.49028  1.000 18.94631 ?  99  GLU A N   1 
ATOM   804  C  CA  . GLU A 1 99  ? 19.16547  1.53994   52.55407  1.000 22.31228 ?  99  GLU A CA  1 
ATOM   805  C  C   . GLU A 1 99  ? 17.88188  0.75448   52.29971  1.000 21.81453 ?  99  GLU A C   1 
ATOM   806  O  O   . GLU A 1 99  ? 16.86839  1.00570   52.95689  1.000 20.90198 ?  99  GLU A O   1 
ATOM   807  C  CB  . GLU A 1 99  ? 19.33871  2.68200   51.55568  1.000 21.26739 ?  99  GLU A CB  1 
ATOM   808  C  CG  . GLU A 1 99  ? 18.29720  3.76455   51.66197  1.000 28.93289 ?  99  GLU A CG  1 
ATOM   809  C  CD  . GLU A 1 99  ? 18.38659  4.52232   52.95945  1.000 28.32202 ?  99  GLU A CD  1 
ATOM   810  O  OE1 . GLU A 1 99  ? 19.47832  4.54066   53.56823  1.000 30.17380 ?  99  GLU A OE1 1 
ATOM   811  O  OE2 . GLU A 1 99  ? 17.35038  5.08509   53.37203  1.000 28.86380 -1 99  GLU A OE2 1 
ATOM   812  N  N   . LEU A 1 100 ? 17.91590  -0.21016  51.36941  1.000 14.68893 ?  100 LEU A N   1 
ATOM   813  C  CA  . LEU A 1 100 ? 16.78337  -1.09606  51.13385  1.000 16.96550 ?  100 LEU A CA  1 
ATOM   814  C  C   . LEU A 1 100 ? 16.47878  -1.98566  52.33161  1.000 21.73553 ?  100 LEU A C   1 
ATOM   815  O  O   . LEU A 1 100 ? 15.33604  -2.42213  52.49775  1.000 14.37232 ?  100 LEU A O   1 
ATOM   816  C  CB  . LEU A 1 100 ? 17.06385  -1.99787  49.93734  1.000 15.18910 ?  100 LEU A CB  1 
ATOM   817  C  CG  . LEU A 1 100 ? 17.05062  -1.38345  48.55113  1.000 16.45640 ?  100 LEU A CG  1 
ATOM   818  C  CD1 . LEU A 1 100 ? 17.33017  -2.49634  47.56768  1.000 12.48509 ?  100 LEU A CD1 1 
ATOM   819  C  CD2 . LEU A 1 100 ? 15.71130  -0.74092  48.29582  1.000 16.43718 ?  100 LEU A CD2 1 
ATOM   820  N  N   . GLY A 1 101 ? 17.48617  -2.30153  53.14265  1.000 20.58539 ?  101 GLY A N   1 
ATOM   821  C  CA  . GLY A 1 101 ? 17.36455  -3.38513  54.09799  1.000 20.04722 ?  101 GLY A CA  1 
ATOM   822  C  C   . GLY A 1 101 ? 16.93089  -4.68899  53.45055  1.000 25.96568 ?  101 GLY A C   1 
ATOM   823  O  O   . GLY A 1 101 ? 15.92302  -5.27665  53.86302  1.000 21.20088 ?  101 GLY A O   1 
ATOM   824  N  N   . LEU A 1 102 ? 17.67500  -5.13370  52.42881  1.000 23.64135 ?  102 LEU A N   1 
ATOM   825  C  CA  . LEU A 1 102 ? 17.36514  -6.36850  51.71230  1.000 20.24243 ?  102 LEU A CA  1 
ATOM   826  C  C   . LEU A 1 102 ? 17.13023  -7.53763  52.65895  1.000 23.44575 ?  102 LEU A C   1 
ATOM   827  O  O   . LEU A 1 102 ? 17.91669  -7.77796  53.57500  1.000 22.04682 ?  102 LEU A O   1 
ATOM   828  C  CB  . LEU A 1 102 ? 18.50632  -6.73338  50.76354  1.000 23.58081 ?  102 LEU A CB  1 
ATOM   829  C  CG  . LEU A 1 102 ? 18.41331  -6.45293  49.27158  1.000 21.59470 ?  102 LEU A CG  1 
ATOM   830  C  CD1 . LEU A 1 102 ? 19.43966  -7.28030  48.53716  1.000 14.75237 ?  102 LEU A CD1 1 
ATOM   831  C  CD2 . LEU A 1 102 ? 17.02960  -6.69983  48.72383  1.000 14.69956 ?  102 LEU A CD2 1 
ATOM   832  N  N   . ASP A 1 103 ? 16.04544  -8.27135  52.40677  1.000 19.82619 ?  103 ASP A N   1 
ATOM   833  C  CA  . ASP A 1 103 ? 15.66390  -9.47047  53.14270  1.000 20.75701 ?  103 ASP A CA  1 
ATOM   834  C  C   . ASP A 1 103 ? 16.83221  -10.44931 53.19238  1.000 22.21080 ?  103 ASP A C   1 
ATOM   835  O  O   . ASP A 1 103 ? 17.25162  -10.98022 52.15755  1.000 14.93555 ?  103 ASP A O   1 
ATOM   836  C  CB  . ASP A 1 103 ? 14.43296  -10.08680 52.47267  1.000 18.95663 ?  103 ASP A CB  1 
ATOM   837  C  CG  . ASP A 1 103 ? 13.86318  -11.27311 53.23195  1.000 20.52210 ?  103 ASP A CG  1 
ATOM   838  O  OD1 . ASP A 1 103 ? 14.38403  -11.60604 54.32010  1.000 29.05415 ?  103 ASP A OD1 1 
ATOM   839  O  OD2 . ASP A 1 103 ? 12.88758  -11.86971 52.72087  1.000 23.85386 -1 103 ASP A OD2 1 
ATOM   840  N  N   . ARG A 1 104 ? 17.38666  -10.66451 54.38193  1.000 23.09300 ?  104 ARG A N   1 
ATOM   841  C  CA  . ARG A 1 104 ? 18.52305  -11.55972 54.52569  1.000 27.07500 ?  104 ARG A CA  1 
ATOM   842  C  C   . ARG A 1 104 ? 18.12148  -13.02646 54.50968  1.000 19.77160 ?  104 ARG A C   1 
ATOM   843  O  O   . ARG A 1 104 ? 18.99857  -13.89174 54.56207  1.000 22.42929 ?  104 ARG A O   1 
ATOM   844  C  CB  . ARG A 1 104 ? 19.28053  -11.24402 55.81626  1.000 29.71519 ?  104 ARG A CB  1 
ATOM   845  C  CG  . ARG A 1 104 ? 19.98915  -9.91288  55.81309  1.000 27.09252 ?  104 ARG A CG  1 
ATOM   846  C  CD  . ARG A 1 104 ? 20.85326  -9.76295  57.03494  1.000 33.44797 ?  104 ARG A CD  1 
ATOM   847  N  NE  . ARG A 1 104 ? 21.74323  -10.90175 57.22237  1.000 35.78105 ?  104 ARG A NE  1 
ATOM   848  C  CZ  . ARG A 1 104 ? 22.99212  -10.95466 56.78202  1.000 42.49256 ?  104 ARG A CZ  1 
ATOM   849  N  NH1 . ARG A 1 104 ? 23.51719  -9.96576  56.07514  1.000 41.37694 ?  104 ARG A NH1 1 
ATOM   850  N  NH2 . ARG A 1 104 ? 23.73330  -12.02450 57.06090  1.000 42.71359 ?  104 ARG A NH2 1 
ATOM   851  N  N   . SER A 1 105 ? 16.83011  -13.32863 54.39464  1.000 18.53034 ?  105 SER A N   1 
ATOM   852  C  CA  . SER A 1 105 ? 16.35239  -14.69512 54.56050  1.000 22.93828 ?  105 SER A CA  1 
ATOM   853  C  C   . SER A 1 105 ? 16.53971  -15.56488 53.32188  1.000 22.88633 ?  105 SER A C   1 
ATOM   854  O  O   . SER A 1 105 ? 16.34526  -16.78156 53.40809  1.000 23.74968 ?  105 SER A O   1 
ATOM   855  C  CB  . SER A 1 105 ? 14.87174  -14.69187 54.96320  1.000 23.96475 ?  105 SER A CB  1 
ATOM   856  O  OG  . SER A 1 105 ? 14.01190  -14.53578 53.83005  1.000 28.67704 ?  105 SER A OG  1 
ATOM   857  N  N   . GLU A 1 106 ? 16.89156  -14.99287 52.17693  1.000 20.16030 ?  106 GLU A N   1 
ATOM   858  C  CA  . GLU A 1 106 ? 17.28483  -15.80521 51.03626  1.000 14.14227 ?  106 GLU A CA  1 
ATOM   859  C  C   . GLU A 1 106 ? 18.28742  -15.01189 50.22948  1.000 19.59259 ?  106 GLU A C   1 
ATOM   860  O  O   . GLU A 1 106 ? 18.38332  -13.77876 50.38726  1.000 18.28544 ?  106 GLU A O   1 
ATOM   861  C  CB  . GLU A 1 106 ? 16.08027  -16.21970 50.17855  1.000 18.22082 ?  106 GLU A CB  1 
ATOM   862  C  CG  . GLU A 1 106 ? 15.33200  -15.06701 49.55109  1.000 16.08767 ?  106 GLU A CG  1 
ATOM   863  C  CD  . GLU A 1 106 ? 14.01224  -15.49526 48.93507  1.000 19.85553 ?  106 GLU A CD  1 
ATOM   864  O  OE1 . GLU A 1 106 ? 14.01116  -16.18421 47.88894  1.000 19.36035 ?  106 GLU A OE1 1 
ATOM   865  O  OE2 . GLU A 1 106 ? 12.96095  -15.13642 49.50033  1.000 24.16389 -1 106 GLU A OE2 1 
ATOM   866  N  N   . PRO A 1 107 ? 19.09177  -15.66557 49.39147  1.000 14.62602 ?  107 PRO A N   1 
ATOM   867  C  CA  . PRO A 1 107 ? 20.05399  -14.94430 48.56684  1.000 15.19878 ?  107 PRO A CA  1 
ATOM   868  C  C   . PRO A 1 107 ? 19.36167  -14.20101 47.43665  1.000 13.84458 ?  107 PRO A C   1 
ATOM   869  O  O   . PRO A 1 107 ? 18.20645  -14.46361 47.10173  1.000 12.78118 ?  107 PRO A O   1 
ATOM   870  C  CB  . PRO A 1 107 ? 20.96921  -16.04718 48.02699  1.000 17.33734 ?  107 PRO A CB  1 
ATOM   871  C  CG  . PRO A 1 107 ? 20.12533  -17.26316 48.01245  1.000 17.27857 ?  107 PRO A CG  1 
ATOM   872  C  CD  . PRO A 1 107 ? 19.26224  -17.13362 49.26493  1.000 16.72598 ?  107 PRO A CD  1 
ATOM   873  N  N   . TRP A 1 108 ? 20.09779  -13.24708 46.85836  1.000 16.00577 ?  108 TRP A N   1 
ATOM   874  C  CA  . TRP A 1 108 ? 19.58771  -12.35940 45.82237  1.000 12.54830 ?  108 TRP A CA  1 
ATOM   875  C  C   . TRP A 1 108 ? 20.45467  -12.45022 44.57581  1.000 15.89634 ?  108 TRP A C   1 
ATOM   876  O  O   . TRP A 1 108 ? 21.57619  -12.96708 44.60466  1.000 13.28233 ?  108 TRP A O   1 
ATOM   877  C  CB  . TRP A 1 108 ? 19.53949  -10.91444 46.31952  1.000 11.42139 ?  108 TRP A CB  1 
ATOM   878  C  CG  . TRP A 1 108 ? 18.47215  -10.71286 47.34232  1.000 14.21373 ?  108 TRP A CG  1 
ATOM   879  C  CD1 . TRP A 1 108 ? 18.50210  -11.12904 48.63820  1.000 18.69691 ?  108 TRP A CD1 1 
ATOM   880  C  CD2 . TRP A 1 108 ? 17.20948  -10.05869 47.15985  1.000 14.42398 ?  108 TRP A CD2 1 
ATOM   881  N  NE1 . TRP A 1 108 ? 17.34211  -10.77159 49.28031  1.000 17.32708 ?  108 TRP A NE1 1 
ATOM   882  C  CE2 . TRP A 1 108 ? 16.53304  -10.10532 48.39738  1.000 16.39263 ?  108 TRP A CE2 1 
ATOM   883  C  CE3 . TRP A 1 108 ? 16.58506  -9.43842  46.07192  1.000 15.29591 ?  108 TRP A CE3 1 
ATOM   884  C  CZ2 . TRP A 1 108 ? 15.25575  -9.56811  48.57910  1.000 11.77461 ?  108 TRP A CZ2 1 
ATOM   885  C  CZ3 . TRP A 1 108 ? 15.31656  -8.89186  46.25497  1.000 15.71621 ?  108 TRP A CZ3 1 
ATOM   886  C  CH2 . TRP A 1 108 ? 14.67073  -8.95889  47.50683  1.000 13.61340 ?  108 TRP A CH2 1 
ATOM   887  N  N   . GLN A 1 109 ? 19.91847  -11.94477 43.47089  1.000 8.69996  ?  109 GLN A N   1 
ATOM   888  C  CA  . GLN A 1 109 ? 20.66574  -11.83260 42.22358  1.000 11.21261 ?  109 GLN A CA  1 
ATOM   889  C  C   . GLN A 1 109 ? 20.44081  -10.43646 41.64901  1.000 10.63377 ?  109 GLN A C   1 
ATOM   890  O  O   . GLN A 1 109 ? 19.30673  -9.93675  41.65091  1.000 11.76744 ?  109 GLN A O   1 
ATOM   891  C  CB  . GLN A 1 109 ? 20.22973  -12.92452 41.22067  1.000 9.72693  ?  109 GLN A CB  1 
ATOM   892  C  CG  . GLN A 1 109 ? 20.90592  -12.87448 39.83451  1.000 6.11262  ?  109 GLN A CG  1 
ATOM   893  C  CD  . GLN A 1 109 ? 20.21739  -11.91649 38.88073  1.000 11.47753 ?  109 GLN A CD  1 
ATOM   894  O  OE1 . GLN A 1 109 ? 18.98558  -11.77541 38.88990  1.000 12.08021 ?  109 GLN A OE1 1 
ATOM   895  N  NE2 . GLN A 1 109 ? 21.00682  -11.24602 38.05608  1.000 11.62893 ?  109 GLN A NE2 1 
ATOM   896  N  N   . ILE A 1 110 ? 21.50500  -9.79443  41.15674  1.000 9.83836  ?  110 ILE A N   1 
ATOM   897  C  CA  . ILE A 1 110 ? 21.36385  -8.44487  40.62013  1.000 9.72046  ?  110 ILE A CA  1 
ATOM   898  C  C   . ILE A 1 110 ? 21.82311  -8.37725  39.16940  1.000 9.81054  ?  110 ILE A C   1 
ATOM   899  O  O   . ILE A 1 110 ? 22.81678  -9.00581  38.77451  1.000 10.63910 ?  110 ILE A O   1 
ATOM   900  C  CB  . ILE A 1 110 ? 22.09822  -7.37857  41.46955  1.000 7.29204  ?  110 ILE A CB  1 
ATOM   901  C  CG1 . ILE A 1 110 ? 23.57095  -7.71657  41.69125  1.000 11.50830 ?  110 ILE A CG1 1 
ATOM   902  C  CG2 . ILE A 1 110 ? 21.37421  -7.14195  42.79015  1.000 9.64521  ?  110 ILE A CG2 1 
ATOM   903  C  CD1 . ILE A 1 110 ? 24.35259  -6.55247  42.35592  1.000 8.18356  ?  110 ILE A CD1 1 
ATOM   904  N  N   . ASN A 1 111 ? 21.08089  -7.60498  38.37343  1.000 6.10154  ?  111 ASN A N   1 
ATOM   905  C  CA  . ASN A 1 111 ? 21.54626  -7.12862  37.08170  1.000 6.86390  ?  111 ASN A CA  1 
ATOM   906  C  C   . ASN A 1 111 ? 22.16190  -5.75437  37.26869  1.000 9.38505  ?  111 ASN A C   1 
ATOM   907  O  O   . ASN A 1 111 ? 21.59337  -4.90450  37.95671  1.000 9.29555  ?  111 ASN A O   1 
ATOM   908  C  CB  . ASN A 1 111 ? 20.41047  -7.02743  36.07051  1.000 6.91029  ?  111 ASN A CB  1 
ATOM   909  C  CG  . ASN A 1 111 ? 19.92513  -8.37355  35.60527  1.000 12.52698 ?  111 ASN A CG  1 
ATOM   910  O  OD1 . ASN A 1 111 ? 20.55698  -9.39373  35.87168  1.000 8.15054  ?  111 ASN A OD1 1 
ATOM   911  N  ND2 . ASN A 1 111 ? 18.78818  -8.38502  34.90311  1.000 13.63073 ?  111 ASN A ND2 1 
ATOM   912  N  N   . VAL A 1 112 ? 23.32492  -5.53995  36.66173  1.000 6.80986  ?  112 VAL A N   1 
ATOM   913  C  CA  . VAL A 1 112 ? 24.05473  -4.28243  36.80905  1.000 5.56353  ?  112 VAL A CA  1 
ATOM   914  C  C   . VAL A 1 112 ? 24.30535  -3.72202  35.42046  1.000 6.88296  ?  112 VAL A C   1 
ATOM   915  O  O   . VAL A 1 112 ? 24.96341  -4.36172  34.59682  1.000 7.20927  ?  112 VAL A O   1 
ATOM   916  C  CB  . VAL A 1 112 ? 25.37166  -4.46373  37.58748  1.000 7.13368  ?  112 VAL A CB  1 
ATOM   917  C  CG1 . VAL A 1 112 ? 26.09655  -3.09650  37.78912  1.000 9.84468  ?  112 VAL A CG1 1 
ATOM   918  C  CG2 . VAL A 1 112 ? 25.07539  -5.09240  38.93011  1.000 9.48269  ?  112 VAL A CG2 1 
ATOM   919  N  N   . HIS A 1 113 ? 23.76305  -2.53693  35.15709  1.000 6.68761  ?  113 HIS A N   1 
ATOM   920  C  CA  . HIS A 1 113 ? 23.85180  -1.88428  33.86133  1.000 6.62736  ?  113 HIS A CA  1 
ATOM   921  C  C   . HIS A 1 113 ? 24.71000  -0.65121  34.02690  1.000 7.30317  ?  113 HIS A C   1 
ATOM   922  O  O   . HIS A 1 113 ? 24.31176  0.29022   34.72444  1.000 9.31725  ?  113 HIS A O   1 
ATOM   923  C  CB  . HIS A 1 113 ? 22.46892  -1.47884  33.34891  1.000 7.28194  ?  113 HIS A CB  1 
ATOM   924  C  CG  . HIS A 1 113 ? 21.53998  -2.63089  33.16106  1.000 8.27270  ?  113 HIS A CG  1 
ATOM   925  N  ND1 . HIS A 1 113 ? 21.26122  -3.17210  31.92553  1.000 11.09098 ?  113 HIS A ND1 1 
ATOM   926  C  CD2 . HIS A 1 113 ? 20.82933  -3.34800  34.05724  1.000 9.46185  ?  113 HIS A CD2 1 
ATOM   927  C  CE1 . HIS A 1 113 ? 20.43366  -4.18908  32.07248  1.000 14.26583 ?  113 HIS A CE1 1 
ATOM   928  N  NE2 . HIS A 1 113 ? 20.15239  -4.31328  33.35777  1.000 12.70855 ?  113 HIS A NE2 1 
ATOM   929  N  N   . GLN A 1 114 ? 25.87207  -0.63941  33.39131  1.000 6.37145  ?  114 GLN A N   1 
ATOM   930  C  CA  . GLN A 1 114 ? 26.66922  0.58202   33.32186  1.000 6.13295  ?  114 GLN A CA  1 
ATOM   931  C  C   . GLN A 1 114 ? 26.27299  1.31733   32.04714  1.000 7.55754  ?  114 GLN A C   1 
ATOM   932  O  O   . GLN A 1 114 ? 26.58118  0.85257   30.94709  1.000 9.08712  ?  114 GLN A O   1 
ATOM   933  C  CB  . GLN A 1 114 ? 28.16761  0.25956   33.33872  1.000 8.22335  ?  114 GLN A CB  1 
ATOM   934  C  CG  . GLN A 1 114 ? 29.02807  1.50090   33.25967  1.000 6.94766  ?  114 GLN A CG  1 
ATOM   935  C  CD  . GLN A 1 114 ? 30.49356  1.18854   33.46815  1.000 10.87227 ?  114 GLN A CD  1 
ATOM   936  O  OE1 . GLN A 1 114 ? 30.90305  0.01794   33.45598  1.000 7.40861  ?  114 GLN A OE1 1 
ATOM   937  N  NE2 . GLN A 1 114 ? 31.29535  2.23637   33.65183  1.000 7.27369  ?  114 GLN A NE2 1 
ATOM   938  N  N   . ASN A 1 115 ? 25.60072  2.46900   32.18501  1.000 9.44614  ?  115 ASN A N   1 
ATOM   939  C  CA  . ASN A 1 115 ? 25.00276  3.18039   31.05978  1.000 6.64235  ?  115 ASN A CA  1 
ATOM   940  C  C   . ASN A 1 115 ? 25.57159  4.58874   30.91882  1.000 6.10590  ?  115 ASN A C   1 
ATOM   941  O  O   . ASN A 1 115 ? 25.64207  5.34717   31.89586  1.000 7.54099  ?  115 ASN A O   1 
ATOM   942  C  CB  . ASN A 1 115 ? 23.46984  3.30865   31.20693  1.000 6.99839  ?  115 ASN A CB  1 
ATOM   943  C  CG  . ASN A 1 115 ? 22.70573  2.03421   30.84165  1.000 12.67576 ?  115 ASN A CG  1 
ATOM   944  O  OD1 . ASN A 1 115 ? 23.24356  0.92071   30.82777  1.000 8.23278  ?  115 ASN A OD1 1 
ATOM   945  N  ND2 . ASN A 1 115 ? 21.40812  2.20643   30.56984  1.000 11.06735 ?  115 ASN A ND2 1 
ATOM   946  N  N   . ARG A 1 116 ? 25.91957  4.94918   29.69022  1.000 6.11951  ?  116 ARG A N   1 
ATOM   947  C  CA  . ARG A 1 116 ? 26.15721  6.33509   29.30526  1.000 8.40898  ?  116 ARG A CA  1 
ATOM   948  C  C   . ARG A 1 116 ? 25.16261  6.70633   28.22495  1.000 7.88647  ?  116 ARG A C   1 
ATOM   949  O  O   . ARG A 1 116 ? 25.04994  6.00881   27.20620  1.000 6.48669  ?  116 ARG A O   1 
ATOM   950  C  CB  . ARG A 1 116 ? 27.58474  6.55289   28.78637  1.000 9.77795  ?  116 ARG A CB  1 
ATOM   951  C  CG  . ARG A 1 116 ? 27.72798  7.80254   27.94562  1.000 10.37680 ?  116 ARG A CG  1 
ATOM   952  C  CD  . ARG A 1 116 ? 29.18719  8.08134   27.63981  1.000 11.34902 ?  116 ARG A CD  1 
ATOM   953  N  NE  . ARG A 1 116 ? 29.90210  8.49356   28.84048  1.000 9.88046  ?  116 ARG A NE  1 
ATOM   954  C  CZ  . ARG A 1 116 ? 31.18420  8.83604   28.85900  1.000 12.33557 ?  116 ARG A CZ  1 
ATOM   955  N  NH1 . ARG A 1 116 ? 31.93443  8.76563   27.77373  1.000 11.16176 ?  116 ARG A NH1 1 
ATOM   956  N  NH2 . ARG A 1 116 ? 31.71566  9.28392   29.98470  1.000 10.51201 ?  116 ARG A NH2 1 
ATOM   957  N  N   . THR A 1 117 ? 24.44593  7.80448   28.43192  1.000 7.21880  ?  117 THR A N   1 
ATOM   958  C  CA  . THR A 1 117 ? 23.61375  8.36330   27.37974  1.000 9.37937  ?  117 THR A CA  1 
ATOM   959  C  C   . THR A 1 117 ? 24.16180  9.72918   26.97783  1.000 9.63730  ?  117 THR A C   1 
ATOM   960  O  O   . THR A 1 117 ? 24.38641  10.58983  27.83290  1.000 10.37942 ?  117 THR A O   1 
ATOM   961  C  CB  . THR A 1 117 ? 22.14415  8.45168   27.82878  1.000 7.42158  ?  117 THR A CB  1 
ATOM   962  O  OG1 . THR A 1 117 ? 21.55820  7.13784   27.78380  1.000 6.08674  ?  117 THR A OG1 1 
ATOM   963  C  CG2 . THR A 1 117 ? 21.38457  9.34655   26.93029  1.000 5.07065  ?  117 THR A CG2 1 
ATOM   964  N  N   . ARG A 1 118 ? 24.35680  9.93404   25.67915  1.000 8.20873  ?  118 ARG A N   1 
ATOM   965  C  CA  . ARG A 1 118 ? 24.85288  11.20449  25.15748  1.000 9.88678  ?  118 ARG A CA  1 
ATOM   966  C  C   . ARG A 1 118 ? 23.70812  12.03487  24.60017  1.000 9.24795  ?  118 ARG A C   1 
ATOM   967  O  O   . ARG A 1 118 ? 22.73777  11.50461  24.04748  1.000 10.34661 ?  118 ARG A O   1 
ATOM   968  C  CB  . ARG A 1 118 ? 25.91446  10.97879  24.06794  1.000 13.98105 ?  118 ARG A CB  1 
ATOM   969  C  CG  . ARG A 1 118 ? 27.20457  10.29510  24.59985  1.000 18.45197 ?  118 ARG A CG  1 
ATOM   970  C  CD  . ARG A 1 118 ? 28.40475  10.36542  23.62231  1.000 18.67520 ?  118 ARG A CD  1 
ATOM   971  N  NE  . ARG A 1 118 ? 29.65673  10.50841  24.36261  1.000 26.69721 ?  118 ARG A NE  1 
ATOM   972  C  CZ  . ARG A 1 118 ? 30.13257  11.66419  24.80787  1.000 29.59233 ?  118 ARG A CZ  1 
ATOM   973  N  NH1 . ARG A 1 118 ? 29.53923  12.81657  24.51497  1.000 30.50321 ?  118 ARG A NH1 1 
ATOM   974  N  NH2 . ARG A 1 118 ? 31.23194  11.66716  25.56172  1.000 38.86380 ?  118 ARG A NH2 1 
ATOM   975  N  N   . ALA A 1 119 ? 23.81580  13.34105  24.76097  1.000 11.65968 ?  119 ALA A N   1 
ATOM   976  C  CA  . ALA A 1 119 ? 22.91311  14.27359  24.12003  1.000 10.99708 ?  119 ALA A CA  1 
ATOM   977  C  C   . ALA A 1 119 ? 23.74084  15.25498  23.30735  1.000 14.87711 ?  119 ALA A C   1 
ATOM   978  O  O   . ALA A 1 119 ? 24.91276  15.50923  23.60953  1.000 14.37589 ?  119 ALA A O   1 
ATOM   979  C  CB  . ALA A 1 119 ? 22.05949  15.03201  25.14274  1.000 12.15107 ?  119 ALA A CB  1 
ATOM   980  N  N   . ASP A 1 120 ? 23.13087  15.79519  22.26341  1.000 15.36140 ?  120 ASP A N   1 
ATOM   981  C  CA  . ASP A 1 120 ? 23.77263  16.86235  21.50694  1.000 13.56829 ?  120 ASP A CA  1 
ATOM   982  C  C   . ASP A 1 120 ? 22.70889  17.85879  21.08907  1.000 18.11499 ?  120 ASP A C   1 
ATOM   983  O  O   . ASP A 1 120 ? 21.50974  17.62447  21.26775  1.000 15.23913 ?  120 ASP A O   1 
ATOM   984  C  CB  . ASP A 1 120 ? 24.51900  16.33680  20.28257  1.000 14.65739 ?  120 ASP A CB  1 
ATOM   985  C  CG  . ASP A 1 120 ? 25.69695  17.20609  19.92270  1.000 26.21124 ?  120 ASP A CG  1 
ATOM   986  O  OD1 . ASP A 1 120 ? 25.66883  18.41702  20.25965  1.000 21.06551 ?  120 ASP A OD1 1 
ATOM   987  O  OD2 . ASP A 1 120 ? 26.64750  16.67211  19.32166  1.000 22.12428 -1 120 ASP A OD2 1 
ATOM   988  N  N   . GLY A 1 121 ? 23.16844  18.96296  20.48782  1.000 15.48659 ?  121 GLY A N   1 
ATOM   989  C  CA  . GLY A 1 121 ? 22.25991  20.04109  20.11816  1.000 19.11952 ?  121 GLY A CA  1 
ATOM   990  C  C   . GLY A 1 121 ? 21.04893  19.56813  19.34041  1.000 21.88725 ?  121 GLY A C   1 
ATOM   991  O  O   . GLY A 1 121 ? 19.91044  19.92248  19.65654  1.000 30.32432 ?  121 GLY A O   1 
ATOM   992  N  N   . GLY A 1 122 ? 21.26431  18.74317  18.31922  1.000 16.14846 ?  122 GLY A N   1 
ATOM   993  C  CA  . GLY A 1 122 ? 20.09258  18.32128  17.55650  1.000 37.54380 ?  122 GLY A CA  1 
ATOM   994  C  C   . GLY A 1 122 ? 19.29667  17.18209  18.17399  1.000 25.77380 ?  122 GLY A C   1 
ATOM   995  O  O   . GLY A 1 122 ? 18.14532  16.94455  17.78513  1.000 21.42625 ?  122 GLY A O   1 
ATOM   996  N  N   . ARG A 1 123 ? 19.87410  16.49007  19.15250  1.000 18.71513 ?  123 ARG A N   1 
ATOM   997  C  CA  . ARG A 1 123 ? 19.55779  15.08681  19.39045  1.000 16.18103 ?  123 ARG A CA  1 
ATOM   998  C  C   . ARG A 1 123 ? 19.55119  14.81298  20.89387  1.000 10.91939 ?  123 ARG A C   1 
ATOM   999  O  O   . ARG A 1 123 ? 20.60107  14.56031  21.48716  1.000 11.81468 ?  123 ARG A O   1 
ATOM   1000 C  CB  . ARG A 1 123 ? 20.57798  14.20282  18.67940  1.000 15.07238 ?  123 ARG A CB  1 
ATOM   1001 C  CG  . ARG A 1 123 ? 20.28479  12.73520  18.75605  1.000 12.72903 ?  123 ARG A CG  1 
ATOM   1002 C  CD  . ARG A 1 123 ? 19.16242  12.33739  17.81154  1.000 12.92423 ?  123 ARG A CD  1 
ATOM   1003 N  NE  . ARG A 1 123 ? 18.86927  10.92328  17.97563  1.000 15.89138 ?  123 ARG A NE  1 
ATOM   1004 C  CZ  . ARG A 1 123 ? 19.55733  9.94958   17.40157  1.000 15.82477 ?  123 ARG A CZ  1 
ATOM   1005 N  NH1 . ARG A 1 123 ? 20.54630  10.20512  16.56243  1.000 16.27921 ?  123 ARG A NH1 1 
ATOM   1006 N  NH2 . ARG A 1 123 ? 19.24805  8.68717   17.68364  1.000 12.87837 ?  123 ARG A NH2 1 
ATOM   1007 N  N   . PRO A 1 124 ? 18.37899  14.84214  21.51812  1.000 10.39864 ?  124 PRO A N   1 
ATOM   1008 C  CA  . PRO A 1 124 ? 18.30777  14.43263  22.92884  1.000 14.66795 ?  124 PRO A CA  1 
ATOM   1009 C  C   . PRO A 1 124 ? 18.67357  12.96355  23.10924  1.000 12.57591 ?  124 PRO A C   1 
ATOM   1010 O  O   . PRO A 1 124 ? 18.72030  12.17137  22.16359  1.000 8.42536  ?  124 PRO A O   1 
ATOM   1011 C  CB  . PRO A 1 124 ? 16.84260  14.70577  23.31185  1.000 16.21100 ?  124 PRO A CB  1 
ATOM   1012 C  CG  . PRO A 1 124 ? 16.11873  14.99328  22.05078  1.000 15.58325 ?  124 PRO A CG  1 
ATOM   1013 C  CD  . PRO A 1 124 ? 17.10131  15.32990  20.98308  1.000 15.59803 ?  124 PRO A CD  1 
ATOM   1014 N  N   . GLY A 1 125 ? 18.96391  12.60921  24.35123  1.000 9.19071  ?  125 GLY A N   1 
ATOM   1015 C  CA  . GLY A 1 125 ? 19.34319  11.26011  24.66675  1.000 9.36040  ?  125 GLY A CA  1 
ATOM   1016 C  C   . GLY A 1 125 ? 18.24985  10.54695  25.42837  1.000 11.54523 ?  125 GLY A C   1 
ATOM   1017 O  O   . GLY A 1 125 ? 18.00012  10.82101  26.60952  1.000 12.11627 ?  125 GLY A O   1 
ATOM   1018 N  N   . PRO A 1 126 ? 17.57344  9.61064   24.76421  1.000 13.68820 ?  126 PRO A N   1 
ATOM   1019 C  CA  . PRO A 1 126 ? 16.43849  8.92503   25.40585  1.000 12.56641 ?  126 PRO A CA  1 
ATOM   1020 C  C   . PRO A 1 126 ? 16.91254  7.99097   26.51090  1.000 8.63447  ?  126 PRO A C   1 
ATOM   1021 O  O   . PRO A 1 126 ? 17.81398  7.17816   26.31385  1.000 11.60783 ?  126 PRO A O   1 
ATOM   1022 C  CB  . PRO A 1 126 ? 15.78568  8.15156   24.25260  1.000 14.63383 ?  126 PRO A CB  1 
ATOM   1023 C  CG  . PRO A 1 126 ? 16.35831  8.73399   22.99148  1.000 15.39934 ?  126 PRO A CG  1 
ATOM   1024 C  CD  . PRO A 1 126 ? 17.74475  9.18654   23.36289  1.000 13.54739 ?  126 PRO A CD  1 
ATOM   1025 N  N   . LEU A 1 127 ? 16.30194  8.12062   27.67779  1.000 7.49326  ?  127 LEU A N   1 
ATOM   1026 C  CA  . LEU A 1 127 ? 16.62008  7.28565   28.83300  1.000 7.15566  ?  127 LEU A CA  1 
ATOM   1027 C  C   . LEU A 1 127 ? 15.63548  6.13876   29.02976  1.000 13.44169 ?  127 LEU A C   1 
ATOM   1028 O  O   . LEU A 1 127 ? 16.04884  5.02431   29.36611  1.000 20.51276 ?  127 LEU A O   1 
ATOM   1029 C  CB  . LEU A 1 127 ? 16.66618  8.14825   30.08967  1.000 6.79986  ?  127 LEU A CB  1 
ATOM   1030 C  CG  . LEU A 1 127 ? 17.79648  9.17623   30.07097  1.000 10.34801 ?  127 LEU A CG  1 
ATOM   1031 C  CD1 . LEU A 1 127 ? 17.70543  10.10189  31.26660  1.000 7.52991  ?  127 LEU A CD1 1 
ATOM   1032 C  CD2 . LEU A 1 127 ? 19.17909  8.46626   30.02527  1.000 7.77105  ?  127 LEU A CD2 1 
ATOM   1033 N  N   . THR A 1 128 ? 14.33592  6.37155   28.82498  1.000 9.86643  ?  128 THR A N   1 
ATOM   1034 C  CA  . THR A 1 128 ? 13.33022  5.32304   28.93594  1.000 11.44949 ?  128 THR A CA  1 
ATOM   1035 C  C   . THR A 1 128 ? 12.42670  5.38315   27.70896  1.000 12.95544 ?  128 THR A C   1 
ATOM   1036 O  O   . THR A 1 128 ? 11.24317  5.72227   27.80501  1.000 11.87027 ?  128 THR A O   1 
ATOM   1037 C  CB  . THR A 1 128 ? 12.52407  5.46695   30.23103  1.000 14.93934 ?  128 THR A CB  1 
ATOM   1038 O  OG1 . THR A 1 128 ? 11.89242  6.74443   30.23520  1.000 7.86632  ?  128 THR A OG1 1 
ATOM   1039 C  CG2 . THR A 1 128 ? 13.43832  5.40338   31.46342  1.000 12.45548 ?  128 THR A CG2 1 
ATOM   1040 N  N   . PRO A 1 129 ? 12.95311  5.04927   26.52981  1.000 13.25813 ?  129 PRO A N   1 
ATOM   1041 C  CA  . PRO A 1 129 ? 12.08492  5.00256   25.35188  1.000 14.34353 ?  129 PRO A CA  1 
ATOM   1042 C  C   . PRO A 1 129 ? 10.96864  3.99576   25.50276  1.000 15.90332 ?  129 PRO A C   1 
ATOM   1043 O  O   . PRO A 1 129 ? 9.95708   4.11871   24.81353  1.000 21.09015 ?  129 PRO A O   1 
ATOM   1044 C  CB  . PRO A 1 129 ? 13.04763  4.61742   24.22334  1.000 15.18466 ?  129 PRO A CB  1 
ATOM   1045 C  CG  . PRO A 1 129 ? 14.10411  3.85567   24.90486  1.000 14.87551 ?  129 PRO A CG  1 
ATOM   1046 C  CD  . PRO A 1 129 ? 14.31036  4.58186   26.20317  1.000 16.36766 ?  129 PRO A CD  1 
ATOM   1047 N  N   . GLU A 1 130 ? 11.11063  3.01348   26.39505  1.000 16.76814 ?  130 GLU A N   1 
ATOM   1048 C  CA  . GLU A 1 130 ? 9.98801   2.14150   26.71136  1.000 20.39133 ?  130 GLU A CA  1 
ATOM   1049 C  C   . GLU A 1 130 ? 8.82408   2.89895   27.35387  1.000 19.20943 ?  130 GLU A C   1 
ATOM   1050 O  O   . GLU A 1 130 ? 7.71385   2.36104   27.43019  1.000 19.11241 ?  130 GLU A O   1 
ATOM   1051 C  CB  . GLU A 1 130 ? 10.45141  0.99607   27.63031  1.000 16.91048 ?  130 GLU A CB  1 
ATOM   1052 C  CG  . GLU A 1 130 ? 10.96039  1.37912   29.02128  1.000 18.26356 ?  130 GLU A CG  1 
ATOM   1053 C  CD  . GLU A 1 130 ? 12.44882  1.70234   29.04212  1.000 21.07634 ?  130 GLU A CD  1 
ATOM   1054 O  OE1 . GLU A 1 130 ? 12.96236  2.26770   28.04789  1.000 19.64068 ?  130 GLU A OE1 1 
ATOM   1055 O  OE2 . GLU A 1 130 ? 13.11048  1.38533   30.04382  1.000 29.94272 -1 130 GLU A OE2 1 
ATOM   1056 N  N   . GLY A 1 131 ? 9.04506   4.12554   27.82251  1.000 13.12508 ?  131 GLY A N   1 
ATOM   1057 C  CA  . GLY A 1 131 ? 8.00075   4.88291   28.50209  1.000 16.49824 ?  131 GLY A CA  1 
ATOM   1058 C  C   . GLY A 1 131 ? 7.84579   4.49016   29.96746  1.000 14.18833 ?  131 GLY A C   1 
ATOM   1059 O  O   . GLY A 1 131 ? 8.73801   3.89137   30.58644  1.000 12.12805 ?  131 GLY A O   1 
ATOM   1060 N  N   . VAL A 1 132 ? 6.69124   4.85375   30.53429  1.000 9.45698  ?  132 VAL A N   1 
ATOM   1061 C  CA  . VAL A 1 132 ? 6.39171   4.49218   31.91488  1.000 8.56149  ?  132 VAL A CA  1 
ATOM   1062 C  C   . VAL A 1 132 ? 6.30539   2.98143   32.02167  1.000 11.23386 ?  132 VAL A C   1 
ATOM   1063 O  O   . VAL A 1 132 ? 5.60126   2.33414   31.24049  1.000 12.82778 ?  132 VAL A O   1 
ATOM   1064 C  CB  . VAL A 1 132 ? 5.07860   5.14577   32.37549  1.000 12.92985 ?  132 VAL A CB  1 
ATOM   1065 C  CG1 . VAL A 1 132 ? 4.71185   4.65392   33.78280  1.000 12.48066 ?  132 VAL A CG1 1 
ATOM   1066 C  CG2 . VAL A 1 132 ? 5.19028   6.66249   32.34045  1.000 10.95754 ?  132 VAL A CG2 1 
ATOM   1067 N  N   . HIS A 1 133 ? 6.98409   2.40779   33.01037  1.000 8.25004  ?  133 HIS A N   1 
ATOM   1068 C  CA  . HIS A 1 133 ? 7.16310   0.96111   32.98726  1.000 10.02892 ?  133 HIS A CA  1 
ATOM   1069 C  C   . HIS A 1 133 ? 7.65140   0.49392   34.34595  1.000 9.76361  ?  133 HIS A C   1 
ATOM   1070 O  O   . HIS A 1 133 ? 8.10965   1.28828   35.17432  1.000 10.67141 ?  133 HIS A O   1 
ATOM   1071 C  CB  . HIS A 1 133 ? 8.16799   0.55574   31.90811  1.000 11.95646 ?  133 HIS A CB  1 
ATOM   1072 C  CG  . HIS A 1 133 ? 9.57761   0.93187   32.25317  1.000 10.76547 ?  133 HIS A CG  1 
ATOM   1073 N  ND1 . HIS A 1 133 ? 10.05250  2.22443   32.14278  1.000 13.39015 ?  133 HIS A ND1 1 
ATOM   1074 C  CD2 . HIS A 1 133 ? 10.59675  0.19916   32.76235  1.000 13.08433 ?  133 HIS A CD2 1 
ATOM   1075 C  CE1 . HIS A 1 133 ? 11.31174  2.26374   32.54687  1.000 12.55113 ?  133 HIS A CE1 1 
ATOM   1076 N  NE2 . HIS A 1 133 ? 11.66649  1.04558   32.92593  1.000 13.38655 ?  133 HIS A NE2 1 
ATOM   1077 N  N   . HIS A 1 134 ? 7.53701   -0.81586  34.56060  1.000 10.70212 ?  134 HIS A N   1 
ATOM   1078 C  CA  . HIS A 1 134 ? 8.23068   -1.53085  35.62498  1.000 9.45744  ?  134 HIS A CA  1 
ATOM   1079 C  C   . HIS A 1 134 ? 9.39240   -2.28289  34.99522  1.000 12.63150 ?  134 HIS A C   1 
ATOM   1080 O  O   . HIS A 1 134 ? 9.26742   -2.77876  33.87562  1.000 11.74000 ?  134 HIS A O   1 
ATOM   1081 C  CB  . HIS A 1 134 ? 7.31014   -2.53302  36.32265  1.000 11.82547 ?  134 HIS A CB  1 
ATOM   1082 C  CG  . HIS A 1 134 ? 6.04567   -1.93908  36.85441  1.000 11.04081 ?  134 HIS A CG  1 
ATOM   1083 N  ND1 . HIS A 1 134 ? 5.92871   -1.48414  38.15065  1.000 11.58953 ?  134 HIS A ND1 1 
ATOM   1084 C  CD2 . HIS A 1 134 ? 4.83045   -1.76311  36.28254  1.000 16.39855 ?  134 HIS A CD2 1 
ATOM   1085 C  CE1 . HIS A 1 134 ? 4.70105   -1.03337  38.34941  1.000 13.99488 ?  134 HIS A CE1 1 
ATOM   1086 N  NE2 . HIS A 1 134 ? 4.01623   -1.18573  37.22979  1.000 13.26832 ?  134 HIS A NE2 1 
ATOM   1087 N  N   . ASP A 1 135 ? 10.52128  -2.38533  35.69989  1.000 8.07945  ?  135 ASP A N   1 
ATOM   1088 C  CA  . ASP A 1 135 ? 11.58471  -3.18929  35.10401  1.000 9.46061  ?  135 ASP A CA  1 
ATOM   1089 C  C   . ASP A 1 135 ? 11.30630  -4.68057  35.22357  1.000 8.69177  ?  135 ASP A C   1 
ATOM   1090 O  O   . ASP A 1 135 ? 11.89134  -5.47172  34.48006  1.000 8.59723  ?  135 ASP A O   1 
ATOM   1091 C  CB  . ASP A 1 135 ? 12.93083  -2.85385  35.72942  1.000 6.60562  ?  135 ASP A CB  1 
ATOM   1092 C  CG  . ASP A 1 135 ? 13.48727  -1.49626  35.25678  1.000 11.01507 ?  135 ASP A CG  1 
ATOM   1093 O  OD1 . ASP A 1 135 ? 13.21104  -1.05761  34.12232  1.000 8.65384  ?  135 ASP A OD1 1 
ATOM   1094 O  OD2 . ASP A 1 135 ? 14.25794  -0.89150  36.01443  1.000 16.24745 -1 135 ASP A OD2 1 
ATOM   1095 N  N   . GLY A 1 136 ? 10.41617  -5.07859  36.12685  1.000 10.24414 ?  136 GLY A N   1 
ATOM   1096 C  CA  . GLY A 1 136 ? 10.10079  -6.46784  36.31536  1.000 11.05203 ?  136 GLY A CA  1 
ATOM   1097 C  C   . GLY A 1 136 ? 10.72321  -7.10404  37.53701  1.000 13.55594 ?  136 GLY A C   1 
ATOM   1098 O  O   . GLY A 1 136 ? 10.53438  -8.31377  37.75217  1.000 9.62303  ?  136 GLY A O   1 
ATOM   1099 N  N   . HIS A 1 137 ? 11.45220  -6.34057  38.34333  1.000 8.97674  ?  137 HIS A N   1 
ATOM   1100 C  CA  . HIS A 1 137 ? 12.17052  -6.88770  39.48526  1.000 12.41709 ?  137 HIS A CA  1 
ATOM   1101 C  C   . HIS A 1 137 ? 11.47396  -6.47830  40.78076  1.000 9.60752  ?  137 HIS A C   1 
ATOM   1102 O  O   . HIS A 1 137 ? 10.38008  -5.91344  40.76213  1.000 11.60766 ?  137 HIS A O   1 
ATOM   1103 C  CB  . HIS A 1 137 ? 13.62590  -6.43422  39.44120  1.000 9.38374  ?  137 HIS A CB  1 
ATOM   1104 C  CG  . HIS A 1 137 ? 14.33638  -6.85925  38.19833  1.000 10.73977 ?  137 HIS A CG  1 
ATOM   1105 N  ND1 . HIS A 1 137 ? 15.19588  -7.93159  38.17361  1.000 8.79669  ?  137 HIS A ND1 1 
ATOM   1106 C  CD2 . HIS A 1 137 ? 14.30465  -6.36909  36.93460  1.000 10.27293 ?  137 HIS A CD2 1 
ATOM   1107 C  CE1 . HIS A 1 137 ? 15.67708  -8.07879  36.95003  1.000 12.76311 ?  137 HIS A CE1 1 
ATOM   1108 N  NE2 . HIS A 1 137 ? 15.15436  -7.14066  36.18151  1.000 8.42861  ?  137 HIS A NE2 1 
ATOM   1109 N  N   . GLU A 1 138 ? 12.10073  -6.78951  41.91652  1.000 7.57478  ?  138 GLU A N   1 
ATOM   1110 C  CA  . GLU A 1 138 ? 11.50328  -6.39141  43.18516  1.000 11.61701 ?  138 GLU A CA  1 
ATOM   1111 C  C   . GLU A 1 138 ? 11.92915  -4.98062  43.57674  1.000 11.60265 ?  138 GLU A C   1 
ATOM   1112 O  O   . GLU A 1 138 ? 11.08848  -4.15846  43.96705  1.000 8.83273  ?  138 GLU A O   1 
ATOM   1113 C  CB  . GLU A 1 138 ? 11.85174  -7.39563  44.27757  1.000 11.26127 ?  138 GLU A CB  1 
ATOM   1114 C  CG  . GLU A 1 138 ? 10.99558  -7.26046  45.49606  1.000 13.74441 ?  138 GLU A CG  1 
ATOM   1115 C  CD  . GLU A 1 138 ? 11.15532  -8.42318  46.48467  1.000 14.19177 ?  138 GLU A CD  1 
ATOM   1116 O  OE1 . GLU A 1 138 ? 11.57620  -9.52221  46.07852  1.000 17.61676 ?  138 GLU A OE1 1 
ATOM   1117 O  OE2 . GLU A 1 138 ? 10.86131  -8.22306  47.67670  1.000 14.55369 -1 138 GLU A OE2 1 
ATOM   1118 N  N   . PHE A 1 139 ? 13.22343  -4.67345  43.45667  1.000 10.32895 ?  139 PHE A N   1 
ATOM   1119 C  CA  . PHE A 1 139 ? 13.73736  -3.33808  43.73126  1.000 10.09194 ?  139 PHE A CA  1 
ATOM   1120 C  C   . PHE A 1 139 ? 14.65531  -2.90786  42.60181  1.000 9.12687  ?  139 PHE A C   1 
ATOM   1121 O  O   . PHE A 1 139 ? 15.28360  -3.73691  41.93819  1.000 8.73560  ?  139 PHE A O   1 
ATOM   1122 C  CB  . PHE A 1 139 ? 14.51967  -3.26099  45.04873  1.000 9.49538  ?  139 PHE A CB  1 
ATOM   1123 C  CG  . PHE A 1 139 ? 13.74409  -3.71813  46.23433  1.000 12.36197 ?  139 PHE A CG  1 
ATOM   1124 C  CD1 . PHE A 1 139 ? 12.75797  -2.90980  46.78489  1.000 11.50197 ?  139 PHE A CD1 1 
ATOM   1125 C  CD2 . PHE A 1 139 ? 14.00806  -4.95693  46.80688  1.000 11.38804 ?  139 PHE A CD2 1 
ATOM   1126 C  CE1 . PHE A 1 139 ? 12.03586  -3.33173  47.88407  1.000 15.32406 ?  139 PHE A CE1 1 
ATOM   1127 C  CE2 . PHE A 1 139 ? 13.30545  -5.37923  47.90676  1.000 12.14476 ?  139 PHE A CE2 1 
ATOM   1128 C  CZ  . PHE A 1 139 ? 12.30897  -4.56298  48.44494  1.000 14.32418 ?  139 PHE A CZ  1 
ATOM   1129 N  N   . VAL A 1 140 ? 14.75349  -1.59911  42.40588  1.000 7.60532  ?  140 VAL A N   1 
ATOM   1130 C  CA  . VAL A 1 140 ? 15.64777  -1.04249  41.39595  1.000 6.41355  ?  140 VAL A CA  1 
ATOM   1131 C  C   . VAL A 1 140 ? 16.38834  0.13440   42.01988  1.000 8.17290  ?  140 VAL A C   1 
ATOM   1132 O  O   . VAL A 1 140 ? 15.78308  0.95699   42.71353  1.000 8.92001  ?  140 VAL A O   1 
ATOM   1133 C  CB  . VAL A 1 140 ? 14.87889  -0.62422  40.12715  1.000 9.51643  ?  140 VAL A CB  1 
ATOM   1134 C  CG1 . VAL A 1 140 ? 15.73322  0.30118   39.24939  1.000 9.23947  ?  140 VAL A CG1 1 
ATOM   1135 C  CG2 . VAL A 1 140 ? 14.46320  -1.86371  39.34515  1.000 7.36666  ?  140 VAL A CG2 1 
ATOM   1136 N  N   . MET A 1 141 ? 17.70283  0.18409   41.81827  1.000 8.10122  ?  141 MET A N   1 
ATOM   1137 C  CA  . MET A 1 141 ? 18.54466  1.28278   42.25906  1.000 8.55902  ?  141 MET A CA  1 
ATOM   1138 C  C   . MET A 1 141 ? 19.10210  1.94175   41.01463  1.000 11.00360 ?  141 MET A C   1 
ATOM   1139 O  O   . MET A 1 141 ? 19.62078  1.24758   40.13023  1.000 7.94835  ?  141 MET A O   1 
ATOM   1140 C  CB  . MET A 1 141 ? 19.69959  0.79481   43.13831  1.000 6.40165  ?  141 MET A CB  1 
ATOM   1141 C  CG  . MET A 1 141 ? 20.67714  1.89881   43.51948  1.000 8.55823  ?  141 MET A CG  1 
ATOM   1142 S  SD  . MET A 1 141 ? 22.05595  1.24946   44.53503  1.000 10.67116 ?  141 MET A SD  1 
ATOM   1143 C  CE  . MET A 1 141 ? 22.91364  2.74392   44.95765  1.000 7.71694  ?  141 MET A CE  1 
ATOM   1144 N  N   . ILE A 1 142 ? 18.99225  3.26703   40.93507  1.000 6.53606  ?  142 ILE A N   1 
ATOM   1145 C  CA  . ILE A 1 142 ? 19.53419  4.00714   39.79348  1.000 6.26697  ?  142 ILE A CA  1 
ATOM   1146 C  C   . ILE A 1 142 ? 20.43172  5.08700   40.35439  1.000 6.54707  ?  142 ILE A C   1 
ATOM   1147 O  O   . ILE A 1 142 ? 19.94781  6.01508   41.00449  1.000 8.21173  ?  142 ILE A O   1 
ATOM   1148 C  CB  . ILE A 1 142 ? 18.44723  4.61537   38.90842  1.000 9.23182  ?  142 ILE A CB  1 
ATOM   1149 C  CG1 . ILE A 1 142 ? 17.54266  3.51815   38.39084  1.000 9.55251  ?  142 ILE A CG1 1 
ATOM   1150 C  CG2 . ILE A 1 142 ? 19.07983  5.41183   37.76095  1.000 8.23954  ?  142 ILE A CG2 1 
ATOM   1151 C  CD1 . ILE A 1 142 ? 16.17856  4.01865   38.02226  1.000 9.59794  ?  142 ILE A CD1 1 
ATOM   1152 N  N   . ALA A 1 143 ? 21.73760  4.96630   40.11198  1.000 7.99757  ?  143 ALA A N   1 
ATOM   1153 C  CA  . ALA A 1 143 ? 22.73606  5.85581   40.68831  1.000 10.40704 ?  143 ALA A CA  1 
ATOM   1154 C  C   . ALA A 1 143 ? 23.34420  6.71132   39.58392  1.000 5.94673  ?  143 ALA A C   1 
ATOM   1155 O  O   . ALA A 1 143 ? 23.67001  6.19242   38.51480  1.000 6.50339  ?  143 ALA A O   1 
ATOM   1156 C  CB  . ALA A 1 143 ? 23.81883  5.04190   41.40327  1.000 8.25243  ?  143 ALA A CB  1 
ATOM   1157 N  N   . ILE A 1 144 ? 23.47652  8.01355   39.83188  1.000 5.49235  ?  144 ILE A N   1 
ATOM   1158 C  CA  . ILE A 1 144 ? 24.06138  8.94979   38.86934  1.000 7.75020  ?  144 ILE A CA  1 
ATOM   1159 C  C   . ILE A 1 144 ? 25.53241  9.10051   39.20370  1.000 12.79393 ?  144 ILE A C   1 
ATOM   1160 O  O   . ILE A 1 144 ? 25.88308  9.51090   40.31802  1.000 8.99582  ?  144 ILE A O   1 
ATOM   1161 C  CB  . ILE A 1 144 ? 23.37034  10.31934  38.91790  1.000 7.16600  ?  144 ILE A CB  1 
ATOM   1162 C  CG1 . ILE A 1 144 ? 21.85654  10.14272  38.88176  1.000 6.80682  ?  144 ILE A CG1 1 
ATOM   1163 C  CG2 . ILE A 1 144 ? 23.87724  11.21571  37.79490  1.000 4.61792  ?  144 ILE A CG2 1 
ATOM   1164 C  CD1 . ILE A 1 144 ? 21.36356  9.41700   37.66077  1.000 7.42520  ?  144 ILE A CD1 1 
ATOM   1165 N  N   . LEU A 1 145 ? 26.39773  8.78967   38.25106  1.000 6.98196  ?  145 LEU A N   1 
ATOM   1166 C  CA  . LEU A 1 145 ? 27.82973  8.89873   38.53024  1.000 8.64336  ?  145 LEU A CA  1 
ATOM   1167 C  C   . LEU A 1 145 ? 28.47783  10.15014  37.96511  1.000 10.77275 ?  145 LEU A C   1 
ATOM   1168 O  O   . LEU A 1 145 ? 29.45895  10.62899  38.54167  1.000 14.48084 ?  145 LEU A O   1 
ATOM   1169 C  CB  . LEU A 1 145 ? 28.56483  7.66135   38.01983  1.000 8.79449  ?  145 LEU A CB  1 
ATOM   1170 C  CG  . LEU A 1 145 ? 28.29502  6.65410   39.14207  1.000 15.48951 ?  145 LEU A CG  1 
ATOM   1171 C  CD1 . LEU A 1 145 ? 27.40758  5.50845   38.73789  1.000 12.10159 ?  145 LEU A CD1 1 
ATOM   1172 C  CD2 . LEU A 1 145 ? 29.57022  6.20101   39.79007  1.000 17.25656 ?  145 LEU A CD2 1 
ATOM   1173 N  N   . ASN A 1 146 ? 27.94871  10.71339  36.88437  1.000 9.17185  ?  146 ASN A N   1 
ATOM   1174 C  CA  . ASN A 1 146 ? 28.54648  11.90768  36.29544  1.000 9.65745  ?  146 ASN A CA  1 
ATOM   1175 C  C   . ASN A 1 146 ? 27.56583  12.47542  35.29912  1.000 13.27849 ?  146 ASN A C   1 
ATOM   1176 O  O   . ASN A 1 146 ? 26.95595  11.71611  34.53862  1.000 9.90915  ?  146 ASN A O   1 
ATOM   1177 C  CB  . ASN A 1 146 ? 29.87153  11.58197  35.58576  1.000 11.79473 ?  146 ASN A CB  1 
ATOM   1178 C  CG  . ASN A 1 146 ? 30.69073  12.82659  35.22313  1.000 19.93997 ?  146 ASN A CG  1 
ATOM   1179 O  OD1 . ASN A 1 146 ? 30.45073  13.93014  35.70519  1.000 14.89122 ?  146 ASN A OD1 1 
ATOM   1180 N  ND2 . ASN A 1 146 ? 31.68424  12.62707  34.36630  1.000 26.79755 ?  146 ASN A ND2 1 
ATOM   1181 N  N   . LYS A 1 147 ? 27.39867  13.79732  35.32242  1.000 10.24848 ?  147 LYS A N   1 
ATOM   1182 C  CA  . LYS A 1 147 ? 26.60608  14.52101  34.33089  1.000 14.44921 ?  147 LYS A CA  1 
ATOM   1183 C  C   . LYS A 1 147 ? 27.45898  15.66070  33.80696  1.000 14.16069 ?  147 LYS A C   1 
ATOM   1184 O  O   . LYS A 1 147 ? 28.05552  16.39849  34.59525  1.000 14.33805 ?  147 LYS A O   1 
ATOM   1185 C  CB  . LYS A 1 147 ? 25.28945  15.06871  34.91474  1.000 8.09019  ?  147 LYS A CB  1 
ATOM   1186 C  CG  . LYS A 1 147 ? 24.26998  13.94643  35.18798  1.000 12.19898 ?  147 LYS A CG  1 
ATOM   1187 C  CD  . LYS A 1 147 ? 22.98711  14.44756  35.83912  1.000 11.80950 ?  147 LYS A CD  1 
ATOM   1188 C  CE  . LYS A 1 147 ? 22.35709  15.58437  35.06664  1.000 10.62392 ?  147 LYS A CE  1 
ATOM   1189 N  NZ  . LYS A 1 147 ? 21.05773  15.97344  35.73776  1.000 8.63031  ?  147 LYS A NZ  1 
ATOM   1190 N  N   . VAL A 1 148 ? 27.54476  15.78159  32.48643  1.000 13.86428 ?  148 VAL A N   1 
ATOM   1191 C  CA  . VAL A 1 148 ? 28.37306  16.79962  31.85063  1.000 20.74162 ?  148 VAL A CA  1 
ATOM   1192 C  C   . VAL A 1 148 ? 27.53532  17.48800  30.78750  1.000 13.52257 ?  148 VAL A C   1 
ATOM   1193 O  O   . VAL A 1 148 ? 27.16486  16.86414  29.79405  1.000 11.99346 ?  148 VAL A O   1 
ATOM   1194 C  CB  . VAL A 1 148 ? 29.64302  16.20226  31.23250  1.000 20.23795 ?  148 VAL A CB  1 
ATOM   1195 C  CG1 . VAL A 1 148 ? 30.40985  17.28413  30.46050  1.000 22.35716 ?  148 VAL A CG1 1 
ATOM   1196 C  CG2 . VAL A 1 148 ? 30.50989  15.57533  32.31701  1.000 16.84079 ?  148 VAL A CG2 1 
ATOM   1197 N  N   . ASN A 1 149 ? 27.21249  18.76475  31.00415  1.000 14.42678 ?  149 ASN A N   1 
ATOM   1198 C  CA  . ASN A 1 149 ? 26.60388  19.59179  29.96755  1.000 13.58406 ?  149 ASN A CA  1 
ATOM   1199 C  C   . ASN A 1 149 ? 25.24983  19.05374  29.51039  1.000 14.58319 ?  149 ASN A C   1 
ATOM   1200 O  O   . ASN A 1 149 ? 24.93287  19.06365  28.31699  1.000 12.53934 ?  149 ASN A O   1 
ATOM   1201 C  CB  . ASN A 1 149 ? 27.54450  19.74603  28.76457  1.000 13.24383 ?  149 ASN A CB  1 
ATOM   1202 C  CG  . ASN A 1 149 ? 27.15754  20.91206  27.88016  1.000 18.50633 ?  149 ASN A CG  1 
ATOM   1203 O  OD1 . ASN A 1 149 ? 26.72430  21.95318  28.37758  1.000 18.02467 ?  149 ASN A OD1 1 
ATOM   1204 N  ND2 . ASN A 1 149 ? 27.26595  20.73208  26.56364  1.000 12.84982 ?  149 ASN A ND2 1 
ATOM   1205 N  N   . VAL A 1 150 ? 24.42719  18.59649  30.45075  1.000 12.73306 ?  150 VAL A N   1 
ATOM   1206 C  CA  . VAL A 1 150 ? 23.09253  18.13489  30.09094  1.000 11.71386 ?  150 VAL A CA  1 
ATOM   1207 C  C   . VAL A 1 150 ? 22.03768  18.84493  30.91815  1.000 14.19849 ?  150 VAL A C   1 
ATOM   1208 O  O   . VAL A 1 150 ? 22.28764  19.28888  32.04065  1.000 12.77033 ?  150 VAL A O   1 
ATOM   1209 C  CB  . VAL A 1 150 ? 22.93844  16.61440  30.26948  1.000 11.45598 ?  150 VAL A CB  1 
ATOM   1210 C  CG1 . VAL A 1 150 ? 23.82764  15.89216  29.28699  1.000 10.20350 ?  150 VAL A CG1 1 
ATOM   1211 C  CG2 . VAL A 1 150 ? 23.28323  16.21313  31.72123  1.000 8.47952  ?  150 VAL A CG2 1 
ATOM   1212 N  N   . ALA A 1 151 ? 20.83651  18.90690  30.36722  1.000 13.83989 ?  151 ALA A N   1 
ATOM   1213 C  CA  . ALA A 1 151 ? 19.62153  19.22723  31.09755  1.000 13.53395 ?  151 ALA A CA  1 
ATOM   1214 C  C   . ALA A 1 151 ? 18.67406  18.02499  30.99890  1.000 12.56096 ?  151 ALA A C   1 
ATOM   1215 O  O   . ALA A 1 151 ? 19.05052  16.94244  30.52240  1.000 15.60344 ?  151 ALA A O   1 
ATOM   1216 C  CB  . ALA A 1 151 ? 18.99333  20.50884  30.54716  1.000 16.70067 ?  151 ALA A CB  1 
ATOM   1217 N  N   . GLY A 1 152 ? 17.43462  18.20992  31.44850  1.000 13.12232 ?  152 GLY A N   1 
ATOM   1218 C  CA  . GLY A 1 152 ? 16.51100  17.08707  31.36317  1.000 10.64178 ?  152 GLY A CA  1 
ATOM   1219 C  C   . GLY A 1 152 ? 16.93920  15.95112  32.27799  1.000 8.02889  ?  152 GLY A C   1 
ATOM   1220 O  O   . GLY A 1 152 ? 17.56618  16.15333  33.32565  1.000 12.49032 ?  152 GLY A O   1 
ATOM   1221 N  N   . GLY A 1 153 ? 16.59661  14.73018  31.88353  1.000 8.20243  ?  153 GLY A N   1 
ATOM   1222 C  CA  . GLY A 1 153 ? 16.99809  13.59847  32.70767  1.000 7.39400  ?  153 GLY A CA  1 
ATOM   1223 C  C   . GLY A 1 153 ? 16.28641  13.57688  34.03972  1.000 10.87570 ?  153 GLY A C   1 
ATOM   1224 O  O   . GLY A 1 153 ? 16.89128  13.24630  35.07092  1.000 9.67780  ?  153 GLY A O   1 
ATOM   1225 N  N   . THR A 1 154 ? 15.00514  13.93603  34.04151  1.000 10.36666 ?  154 THR A N   1 
ATOM   1226 C  CA  . THR A 1 154 ? 14.20837  14.01565  35.25688  1.000 9.34346  ?  154 THR A CA  1 
ATOM   1227 C  C   . THR A 1 154 ? 13.48523  12.69476  35.49421  1.000 10.10164 ?  154 THR A C   1 
ATOM   1228 O  O   . THR A 1 154 ? 12.72017  12.23053  34.63540  1.000 11.85078 ?  154 THR A O   1 
ATOM   1229 C  CB  . THR A 1 154 ? 13.20883  15.16148  35.15940  1.000 10.47288 ?  154 THR A CB  1 
ATOM   1230 O  OG1 . THR A 1 154 ? 13.93276  16.39641  35.05244  1.000 12.03901 ?  154 THR A OG1 1 
ATOM   1231 C  CG2 . THR A 1 154 ? 12.29775  15.19066  36.38912  1.000 7.77075  ?  154 THR A CG2 1 
ATOM   1232 N  N   . THR A 1 155 ? 13.72990  12.10154  36.65764  1.000 8.29824  ?  155 THR A N   1 
ATOM   1233 C  CA  . THR A 1 155 ? 13.06780  10.86084  37.04206  1.000 6.80959  ?  155 THR A CA  1 
ATOM   1234 C  C   . THR A 1 155 ? 11.64928  11.16206  37.50640  1.000 12.20040 ?  155 THR A C   1 
ATOM   1235 O  O   . THR A 1 155 ? 11.42861  12.08907  38.28677  1.000 10.71791 ?  155 THR A O   1 
ATOM   1236 C  CB  . THR A 1 155 ? 13.83482  10.18650  38.16921  1.000 10.68533 ?  155 THR A CB  1 
ATOM   1237 O  OG1 . THR A 1 155 ? 15.17292  9.87409   37.73959  1.000 8.15382  ?  155 THR A OG1 1 
ATOM   1238 C  CG2 . THR A 1 155 ? 13.11245  8.90480   38.63120  1.000 6.39496  ?  155 THR A CG2 1 
ATOM   1239 N  N   . ARG A 1 156 ? 10.68993  10.36779  37.03640  1.000 8.01101  ?  156 ARG A N   1 
ATOM   1240 C  CA  . ARG A 1 156 ? 9.28944   10.53841  37.40907  1.000 8.83270  ?  156 ARG A CA  1 
ATOM   1241 C  C   . ARG A 1 156 ? 8.74340   9.20564   37.89802  1.000 10.34700 ?  156 ARG A C   1 
ATOM   1242 O  O   . ARG A 1 156 ? 8.90826   8.17958   37.22570  1.000 7.54768  ?  156 ARG A O   1 
ATOM   1243 C  CB  . ARG A 1 156 ? 8.48855   11.05736  36.21806  1.000 9.02865  ?  156 ARG A CB  1 
ATOM   1244 C  CG  . ARG A 1 156 ? 9.17208   12.25361  35.53920  1.000 12.63325 ?  156 ARG A CG  1 
ATOM   1245 C  CD  . ARG A 1 156 ? 8.26813   12.90193  34.55080  1.000 14.15380 ?  156 ARG A CD  1 
ATOM   1246 N  NE  . ARG A 1 156 ? 8.04496   12.03493  33.40572  1.000 11.06389 ?  156 ARG A NE  1 
ATOM   1247 C  CZ  . ARG A 1 156 ? 7.45592   12.43667  32.29002  1.000 16.06852 ?  156 ARG A CZ  1 
ATOM   1248 N  NH1 . ARG A 1 156 ? 7.04148   13.68079  32.14519  1.000 16.24143 ?  156 ARG A NH1 1 
ATOM   1249 N  NH2 . ARG A 1 156 ? 7.27130   11.56688  31.30069  1.000 13.22687 ?  156 ARG A NH2 1 
ATOM   1250 N  N   . LEU A 1 157 ? 8.10419   9.20838   39.06485  1.000 6.31204  ?  157 LEU A N   1 
ATOM   1251 C  CA  . LEU A 1 157 ? 7.57969   7.97928   39.65333  1.000 5.01669  ?  157 LEU A CA  1 
ATOM   1252 C  C   . LEU A 1 157 ? 6.05570   7.98789   39.56448  1.000 11.68206 ?  157 LEU A C   1 
ATOM   1253 O  O   . LEU A 1 157 ? 5.43240   9.01989   39.79803  1.000 9.28410  ?  157 LEU A O   1 
ATOM   1254 C  CB  . LEU A 1 157 ? 8.03721   7.85418   41.11032  1.000 5.17593  ?  157 LEU A CB  1 
ATOM   1255 C  CG  . LEU A 1 157 ? 9.57726   7.83709   41.23492  1.000 6.80964  ?  157 LEU A CG  1 
ATOM   1256 C  CD1 . LEU A 1 157 ? 9.97617   7.64290   42.68595  1.000 5.60523  ?  157 LEU A CD1 1 
ATOM   1257 C  CD2 . LEU A 1 157 ? 10.16199  6.71303   40.38282  1.000 7.27262  ?  157 LEU A CD2 1 
ATOM   1258 N  N   . TRP A 1 158 ? 5.45517   6.84540   39.22999  1.000 9.17025  ?  158 TRP A N   1 
ATOM   1259 C  CA  . TRP A 1 158 ? 4.03064   6.78223   38.91233  1.000 10.07030 ?  158 TRP A CA  1 
ATOM   1260 C  C   . TRP A 1 158 ? 3.34384   5.67554   39.69768  1.000 12.60342 ?  158 TRP A C   1 
ATOM   1261 O  O   . TRP A 1 158 ? 3.82532   4.53990   39.73147  1.000 14.12680 ?  158 TRP A O   1 
ATOM   1262 C  CB  . TRP A 1 158 ? 3.80701   6.50702   37.42800  1.000 11.12678 ?  158 TRP A CB  1 
ATOM   1263 C  CG  . TRP A 1 158 ? 4.52675   7.42898   36.48347  1.000 13.28196 ?  158 TRP A CG  1 
ATOM   1264 C  CD1 . TRP A 1 158 ? 5.89201   7.59106   36.35401  1.000 12.89722 ?  158 TRP A CD1 1 
ATOM   1265 C  CD2 . TRP A 1 158 ? 3.93328   8.27282   35.49445  1.000 11.35057 ?  158 TRP A CD2 1 
ATOM   1266 N  NE1 . TRP A 1 158 ? 6.17080   8.50338   35.36210  1.000 8.32326  ?  158 TRP A NE1 1 
ATOM   1267 C  CE2 . TRP A 1 158 ? 4.98658   8.93662   34.82060  1.000 10.81411 ?  158 TRP A CE2 1 
ATOM   1268 C  CE3 . TRP A 1 158 ? 2.60985   8.54061   35.11031  1.000 15.07582 ?  158 TRP A CE3 1 
ATOM   1269 C  CZ2 . TRP A 1 158 ? 4.75918   9.84228   33.78373  1.000 13.57995 ?  158 TRP A CZ2 1 
ATOM   1270 C  CZ3 . TRP A 1 158 ? 2.38603   9.45149   34.07792  1.000 14.00870 ?  158 TRP A CZ3 1 
ATOM   1271 C  CH2 . TRP A 1 158 ? 3.45653   10.08993  33.43013  1.000 16.04345 ?  158 TRP A CH2 1 
ATOM   1272 N  N   . LYS A 1 159 ? 2.19453   5.99330   40.29006  1.000 15.47165 ?  159 LYS A N   1 
ATOM   1273 C  CA  . LYS A 1 159 ? 1.35482   4.94187   40.83407  1.000 13.18661 ?  159 LYS A CA  1 
ATOM   1274 C  C   . LYS A 1 159 ? 0.79387   4.10161   39.68829  1.000 10.29349 ?  159 LYS A C   1 
ATOM   1275 O  O   . LYS A 1 159 ? 0.62821   4.59355   38.57037  1.000 10.52390 ?  159 LYS A O   1 
ATOM   1276 C  CB  . LYS A 1 159 ? 0.21335   5.52074   41.68012  1.000 16.40730 ?  159 LYS A CB  1 
ATOM   1277 C  CG  . LYS A 1 159 ? 0.65451   6.43295   42.83805  1.000 17.62642 ?  159 LYS A CG  1 
ATOM   1278 C  CD  . LYS A 1 159 ? 1.29866   5.68337   43.99960  1.000 23.56005 ?  159 LYS A CD  1 
ATOM   1279 C  CE  . LYS A 1 159 ? 1.74455   6.65726   45.10581  1.000 28.45386 ?  159 LYS A CE  1 
ATOM   1280 N  NZ  . LYS A 1 159 ? 0.90001   6.62195   46.34086  1.000 39.36440 ?  159 LYS A NZ  1 
ATOM   1281 N  N   . PRO A 1 160 ? 0.53107   2.81937   39.92755  1.000 14.98872 ?  160 PRO A N   1 
ATOM   1282 C  CA  . PRO A 1 160 ? 0.03909   1.95154   38.84969  1.000 15.32402 ?  160 PRO A CA  1 
ATOM   1283 C  C   . PRO A 1 160 ? -1.19805  2.53472   38.17703  1.000 15.97511 ?  160 PRO A C   1 
ATOM   1284 O  O   . PRO A 1 160 ? -2.14947  2.94508   38.83340  1.000 16.50424 ?  160 PRO A O   1 
ATOM   1285 C  CB  . PRO A 1 160 ? -0.27793  0.63919   39.57506  1.000 23.75964 ?  160 PRO A CB  1 
ATOM   1286 C  CG  . PRO A 1 160 ? 0.64885   0.64175   40.75942  1.000 22.48897 ?  160 PRO A CG  1 
ATOM   1287 C  CD  . PRO A 1 160 ? 0.76904   2.08128   41.18178  1.000 17.23345 ?  160 PRO A CD  1 
ATOM   1288 N  N   . GLY A 1 161 ? -1.15369  2.62360   36.85580  1.000 13.63500 ?  161 GLY A N   1 
ATOM   1289 C  CA  . GLY A 1 161 ? -2.27362  3.12699   36.09054  1.000 16.22157 ?  161 GLY A CA  1 
ATOM   1290 C  C   . GLY A 1 161 ? -2.51709  4.62234   36.15488  1.000 16.92552 ?  161 GLY A C   1 
ATOM   1291 O  O   . GLY A 1 161 ? -3.40699  5.10642   35.45126  1.000 17.05254 ?  161 GLY A O   1 
ATOM   1292 N  N   . ALA A 1 162 ? -1.75864  5.37434   36.95027  1.000 13.02569 ?  162 ALA A N   1 
ATOM   1293 C  CA  . ALA A 1 162 ? -1.97372  6.81480   37.04195  1.000 16.04692 ?  162 ALA A CA  1 
ATOM   1294 C  C   . ALA A 1 162 ? -1.67268  7.50589   35.71199  1.000 17.56447 ?  162 ALA A C   1 
ATOM   1295 O  O   . ALA A 1 162 ? -0.92054  6.99747   34.87871  1.000 16.41246 ?  162 ALA A O   1 
ATOM   1296 C  CB  . ALA A 1 162 ? -1.09805  7.41914   38.14095  1.000 15.01989 ?  162 ALA A CB  1 
ATOM   1297 N  N   . ASP A 1 163 ? -2.27966  8.67736   35.51653  1.000 12.49828 ?  163 ASP A N   1 
ATOM   1298 C  CA  . ASP A 1 163 ? -2.07221  9.47311   34.30786  1.000 20.37583 ?  163 ASP A CA  1 
ATOM   1299 C  C   . ASP A 1 163 ? -1.05984  10.59672  34.49575  1.000 16.20206 ?  163 ASP A C   1 
ATOM   1300 O  O   . ASP A 1 163 ? -0.82203  11.36000  33.55040  1.000 18.80955 ?  163 ASP A O   1 
ATOM   1301 C  CB  . ASP A 1 163 ? -3.40306  10.07036  33.81649  1.000 24.54664 ?  163 ASP A CB  1 
ATOM   1302 C  CG  . ASP A 1 163 ? -4.01815  11.03982  34.81557  1.000 31.73652 ?  163 ASP A CG  1 
ATOM   1303 O  OD1 . ASP A 1 163 ? -3.45796  11.21648  35.92610  1.000 42.45380 ?  163 ASP A OD1 1 
ATOM   1304 O  OD2 . ASP A 1 163 ? -5.07676  11.61675  34.49309  1.000 47.89380 -1 163 ASP A OD2 1 
ATOM   1305 N  N   . ALA A 1 164 ? -0.50044  10.73980  35.69442  1.000 17.67303 ?  164 ALA A N   1 
ATOM   1306 C  CA  . ALA A 1 164 ? 0.52709   11.72151  36.00412  1.000 15.83388 ?  164 ALA A CA  1 
ATOM   1307 C  C   . ALA A 1 164 ? 1.39742   11.11857  37.08791  1.000 14.28037 ?  164 ALA A C   1 
ATOM   1308 O  O   . ALA A 1 164 ? 0.90316   10.32573  37.89697  1.000 14.31120 ?  164 ALA A O   1 
ATOM   1309 C  CB  . ALA A 1 164 ? -0.06556  13.05717  36.49145  1.000 10.26789 ?  164 ALA A CB  1 
ATOM   1310 N  N   . PRO A 1 165 ? 2.68053   11.48164  37.14536  1.000 14.53517 ?  165 PRO A N   1 
ATOM   1311 C  CA  . PRO A 1 165 ? 3.53558   10.96409  38.21983  1.000 11.24513 ?  165 PRO A CA  1 
ATOM   1312 C  C   . PRO A 1 165 ? 3.24097   11.68512  39.51908  1.000 11.93739 ?  165 PRO A C   1 
ATOM   1313 O  O   . PRO A 1 165 ? 2.84780   12.85065  39.53184  1.000 16.16217 ?  165 PRO A O   1 
ATOM   1314 C  CB  . PRO A 1 165 ? 4.95518   11.27063  37.72545  1.000 11.69660 ?  165 PRO A CB  1 
ATOM   1315 C  CG  . PRO A 1 165 ? 4.79872   12.53318  36.91686  1.000 12.68740 ?  165 PRO A CG  1 
ATOM   1316 C  CD  . PRO A 1 165 ? 3.39975   12.43279  36.27099  1.000 14.35899 ?  165 PRO A CD  1 
ATOM   1317 N  N   . PHE A 1 166 ? 3.43880   10.98639  40.62676  1.000 8.81928  ?  166 PHE A N   1 
ATOM   1318 C  CA  . PHE A 1 166 ? 3.22443   11.61198  41.91778  1.000 13.10337 ?  166 PHE A CA  1 
ATOM   1319 C  C   . PHE A 1 166 ? 4.48799   12.24464  42.47415  1.000 13.88141 ?  166 PHE A C   1 
ATOM   1320 O  O   . PHE A 1 166 ? 4.39893   13.02723  43.42575  1.000 16.15356 ?  166 PHE A O   1 
ATOM   1321 C  CB  . PHE A 1 166 ? 2.67563   10.59004  42.92558  1.000 18.82453 ?  166 PHE A CB  1 
ATOM   1322 C  CG  . PHE A 1 166 ? 3.67133   9.55693   43.33566  1.000 15.85428 ?  166 PHE A CG  1 
ATOM   1323 C  CD1 . PHE A 1 166 ? 3.87930   8.42318   42.55042  1.000 13.98551 ?  166 PHE A CD1 1 
ATOM   1324 C  CD2 . PHE A 1 166 ? 4.40138   9.71602   44.50914  1.000 15.09165 ?  166 PHE A CD2 1 
ATOM   1325 C  CE1 . PHE A 1 166 ? 4.80563   7.47226   42.92762  1.000 15.77449 ?  166 PHE A CE1 1 
ATOM   1326 C  CE2 . PHE A 1 166 ? 5.32474   8.78564   44.89866  1.000 18.73961 ?  166 PHE A CE2 1 
ATOM   1327 C  CZ  . PHE A 1 166 ? 5.53883   7.64894   44.11343  1.000 13.32204 ?  166 PHE A CZ  1 
ATOM   1328 N  N   . TRP A 1 167 ? 5.65659   11.91937  41.91390  1.000 11.27843 ?  167 TRP A N   1 
ATOM   1329 C  CA  . TRP A 1 167 ? 6.92222   12.47401  42.37010  1.000 13.12943 ?  167 TRP A CA  1 
ATOM   1330 C  C   . TRP A 1 167 ? 7.83376   12.64910  41.17075  1.000 13.41016 ?  167 TRP A C   1 
ATOM   1331 O  O   . TRP A 1 167 ? 7.86778   11.78920  40.28981  1.000 13.31425 ?  167 TRP A O   1 
ATOM   1332 C  CB  . TRP A 1 167 ? 7.61473   11.57588  43.40590  1.000 15.94744 ?  167 TRP A CB  1 
ATOM   1333 C  CG  . TRP A 1 167 ? 8.91759   12.15405  43.91858  1.000 12.60827 ?  167 TRP A CG  1 
ATOM   1334 C  CD1 . TRP A 1 167 ? 9.08224   12.98060  44.99238  1.000 16.61794 ?  167 TRP A CD1 1 
ATOM   1335 C  CD2 . TRP A 1 167 ? 10.23132  11.95388  43.36489  1.000 10.61028 ?  167 TRP A CD2 1 
ATOM   1336 N  NE1 . TRP A 1 167 ? 10.40980  13.29853  45.14459  1.000 16.11023 ?  167 TRP A NE1 1 
ATOM   1337 C  CE2 . TRP A 1 167 ? 11.13349  12.67955  44.15947  1.000 15.20302 ?  167 TRP A CE2 1 
ATOM   1338 C  CE3 . TRP A 1 167 ? 10.72386  11.23121  42.27570  1.000 14.82795 ?  167 TRP A CE3 1 
ATOM   1339 C  CZ2 . TRP A 1 167 ? 12.50040  12.70986  43.89868  1.000 11.86742 ?  167 TRP A CZ2 1 
ATOM   1340 C  CZ3 . TRP A 1 167 ? 12.08904  11.25403  42.02507  1.000 12.70064 ?  167 TRP A CZ3 1 
ATOM   1341 C  CH2 . TRP A 1 167 ? 12.95390  11.98867  42.83190  1.000 16.86654 ?  167 TRP A CH2 1 
ATOM   1342 N  N   . SER A 1 168 ? 8.57968   13.75625  41.14266  1.000 13.96308 ?  168 SER A N   1 
ATOM   1343 C  CA  . SER A 1 168 ? 9.55176   14.00130  40.08249  1.000 15.52349 ?  168 SER A CA  1 
ATOM   1344 C  C   . SER A 1 168 ? 10.80107  14.59636  40.70082  1.000 15.95482 ?  168 SER A C   1 
ATOM   1345 O  O   . SER A 1 168 ? 10.71799  15.41019  41.62136  1.000 19.19446 ?  168 SER A O   1 
ATOM   1346 C  CB  . SER A 1 168 ? 9.02092   14.95558  38.98960  1.000 14.14606 ?  168 SER A CB  1 
ATOM   1347 O  OG  . SER A 1 168 ? 7.94112   14.36059  38.28181  1.000 27.85539 ?  168 SER A OG  1 
ATOM   1348 N  N   . GLY A 1 169 ? 11.95937  14.19253  40.18159  1.000 13.38932 ?  169 GLY A N   1 
ATOM   1349 C  CA  . GLY A 1 169 ? 13.21432  14.76159  40.63859  1.000 13.34362 ?  169 GLY A CA  1 
ATOM   1350 C  C   . GLY A 1 169 ? 14.32502  14.55101  39.63808  1.000 15.14120 ?  169 GLY A C   1 
ATOM   1351 O  O   . GLY A 1 169 ? 14.45234  13.45461  39.08796  1.000 9.11326  ?  169 GLY A O   1 
ATOM   1352 N  N   . THR A 1 170 ? 15.11067  15.59123  39.35800  1.000 8.95619  ?  170 THR A N   1 
ATOM   1353 C  CA  . THR A 1 170 ? 16.28215  15.43289  38.49900  1.000 10.64953 ?  170 THR A CA  1 
ATOM   1354 C  C   . THR A 1 170 ? 17.45448  14.99382  39.36195  1.000 10.74346 ?  170 THR A C   1 
ATOM   1355 O  O   . THR A 1 170 ? 17.96946  15.77072  40.17291  1.000 9.44526  ?  170 THR A O   1 
ATOM   1356 C  CB  . THR A 1 170 ? 16.59640  16.72147  37.75140  1.000 13.12755 ?  170 THR A CB  1 
ATOM   1357 O  OG1 . THR A 1 170 ? 15.46517  17.05323  36.95302  1.000 11.86960 ?  170 THR A OG1 1 
ATOM   1358 C  CG2 . THR A 1 170 ? 17.80107  16.50614  36.84233  1.000 8.07793  ?  170 THR A CG2 1 
ATOM   1359 N  N   . LEU A 1 171 ? 17.83993  13.73291  39.23050  1.000 8.33402  ?  171 LEU A N   1 
ATOM   1360 C  CA  . LEU A 1 171 ? 18.91439  13.18680  40.04692  1.000 6.28571  ?  171 LEU A CA  1 
ATOM   1361 C  C   . LEU A 1 171 ? 20.24980  13.68641  39.54206  1.000 5.06974  ?  171 LEU A C   1 
ATOM   1362 O  O   . LEU A 1 171 ? 20.49374  13.71542  38.32939  1.000 5.08568  ?  171 LEU A O   1 
ATOM   1363 C  CB  . LEU A 1 171 ? 18.88335  11.66182  39.99919  1.000 4.98829  ?  171 LEU A CB  1 
ATOM   1364 C  CG  . LEU A 1 171 ? 17.59695  10.97065  40.46642  1.000 5.69336  ?  171 LEU A CG  1 
ATOM   1365 C  CD1 . LEU A 1 171 ? 17.71751  9.45608   40.21435  1.000 4.51591  ?  171 LEU A CD1 1 
ATOM   1366 C  CD2 . LEU A 1 171 ? 17.38934  11.24121  41.92972  1.000 8.63512  ?  171 LEU A CD2 1 
ATOM   1367 N  N   . GLU A 1 172 ? 21.11956  14.07097  40.47433  1.000 6.55387  ?  172 GLU A N   1 
ATOM   1368 C  CA  . GLU A 1 172 ? 22.41547  14.63991  40.11107  1.000 5.55325  ?  172 GLU A CA  1 
ATOM   1369 C  C   . GLU A 1 172 ? 23.52353  13.68020  40.48728  1.000 5.87012  ?  172 GLU A C   1 
ATOM   1370 O  O   . GLU A 1 172 ? 23.31046  12.72147  41.22582  1.000 6.95620  ?  172 GLU A O   1 
ATOM   1371 C  CB  . GLU A 1 172 ? 22.64968  15.99252  40.79726  1.000 6.77594  ?  172 GLU A CB  1 
ATOM   1372 C  CG  . GLU A 1 172 ? 21.54063  16.98951  40.56811  1.000 9.50881  ?  172 GLU A CG  1 
ATOM   1373 C  CD  . GLU A 1 172 ? 21.40778  17.40070  39.12176  1.000 10.33694 ?  172 GLU A CD  1 
ATOM   1374 O  OE1 . GLU A 1 172 ? 22.31163  17.09956  38.30988  1.000 9.94540  ?  172 GLU A OE1 1 
ATOM   1375 O  OE2 . GLU A 1 172 ? 20.37545  18.01855  38.79837  1.000 8.67937  -1 172 GLU A OE2 1 
ATOM   1376 N  N   . ALA A 1 173 ? 24.70727  13.94460  39.93834  1.000 9.79979  ?  173 ALA A N   1 
ATOM   1377 C  CA  . ALA A 1 173 ? 25.88007  13.13099  40.22943  1.000 8.76297  ?  173 ALA A CA  1 
ATOM   1378 C  C   . ALA A 1 173 ? 26.05361  13.02567  41.73125  1.000 11.41817 ?  173 ALA A C   1 
ATOM   1379 O  O   . ALA A 1 173 ? 25.97071  14.02658  42.44679  1.000 12.58302 ?  173 ALA A O   1 
ATOM   1380 C  CB  . ALA A 1 173 ? 27.12690  13.74483  39.59217  1.000 8.31312  ?  173 ALA A CB  1 
ATOM   1381 N  N   . GLY A 1 174 ? 26.25378  11.80111  42.20798  1.000 7.92959  ?  174 GLY A N   1 
ATOM   1382 C  CA  . GLY A 1 174 ? 26.33612  11.54968  43.62609  1.000 8.52472  ?  174 GLY A CA  1 
ATOM   1383 C  C   . GLY A 1 174 ? 25.03002  11.19840  44.29718  1.000 9.68009  ?  174 GLY A C   1 
ATOM   1384 O  O   . GLY A 1 174 ? 25.02443  10.98663  45.52208  1.000 11.65263 ?  174 GLY A O   1 
ATOM   1385 N  N   . GLN A 1 175 ? 23.92766  11.14120  43.54812  1.000 6.16240  ?  175 GLN A N   1 
ATOM   1386 C  CA  . GLN A 1 175 ? 22.63129  10.73322  44.07052  1.000 9.36235  ?  175 GLN A CA  1 
ATOM   1387 C  C   . GLN A 1 175 ? 22.20856  9.40173   43.47020  1.000 8.79363  ?  175 GLN A C   1 
ATOM   1388 O  O   . GLN A 1 175 ? 22.64497  9.01191   42.38488  1.000 9.81125  ?  175 GLN A O   1 
ATOM   1389 C  CB  . GLN A 1 175 ? 21.54091  11.77269  43.77531  1.000 7.11340  ?  175 GLN A CB  1 
ATOM   1390 C  CG  . GLN A 1 175 ? 21.82602  13.14882  44.33337  1.000 10.88835 ?  175 GLN A CG  1 
ATOM   1391 C  CD  . GLN A 1 175 ? 20.62096  14.03353  44.19567  1.000 10.43756 ?  175 GLN A CD  1 
ATOM   1392 O  OE1 . GLN A 1 175 ? 20.31340  14.47609  43.09554  1.000 9.53554  ?  175 GLN A OE1 1 
ATOM   1393 N  NE2 . GLN A 1 175 ? 19.91544  14.27451  45.29724  1.000 9.12084  ?  175 GLN A NE2 1 
ATOM   1394 N  N   . ALA A 1 176 ? 21.34054  8.70532   44.19571  1.000 7.76443  ?  176 ALA A N   1 
ATOM   1395 C  CA  . ALA A 1 176 ? 20.71320  7.49343   43.68649  1.000 8.83205  ?  176 ALA A CA  1 
ATOM   1396 C  C   . ALA A 1 176 ? 19.27008  7.42576   44.16789  1.000 9.45716  ?  176 ALA A C   1 
ATOM   1397 O  O   . ALA A 1 176 ? 18.95587  7.83897   45.28687  1.000 11.13450 ?  176 ALA A O   1 
ATOM   1398 C  CB  . ALA A 1 176 ? 21.45652  6.22683   44.14046  1.000 6.33518  ?  176 ALA A CB  1 
ATOM   1399 N  N   . VAL A 1 177 ? 18.39471  6.86506   43.33954  1.000 6.72213  ?  177 VAL A N   1 
ATOM   1400 C  CA  . VAL A 1 177 ? 17.02968  6.57659   43.76629  1.000 6.88100  ?  177 VAL A CA  1 
ATOM   1401 C  C   . VAL A 1 177 ? 16.89590  5.06966   43.93072  1.000 8.76740  ?  177 VAL A C   1 
ATOM   1402 O  O   . VAL A 1 177 ? 17.37211  4.29171   43.09416  1.000 8.70459  ?  177 VAL A O   1 
ATOM   1403 C  CB  . VAL A 1 177 ? 15.95691  7.12638   42.80326  1.000 8.52754  ?  177 VAL A CB  1 
ATOM   1404 C  CG1 . VAL A 1 177 ? 16.01616  6.47129   41.43485  1.000 6.85628  ?  177 VAL A CG1 1 
ATOM   1405 C  CG2 . VAL A 1 177 ? 14.54273  6.95698   43.41090  1.000 8.12073  ?  177 VAL A CG2 1 
ATOM   1406 N  N   . LEU A 1 178 ? 16.28121  4.66987   45.03465  1.000 6.34230  ?  178 LEU A N   1 
ATOM   1407 C  CA  . LEU A 1 178 ? 15.91418  3.28705   45.29872  1.000 9.36870  ?  178 LEU A CA  1 
ATOM   1408 C  C   . LEU A 1 178 ? 14.40050  3.18733   45.19498  1.000 12.25631 ?  178 LEU A C   1 
ATOM   1409 O  O   . LEU A 1 178 ? 13.68635  4.00329   45.78815  1.000 11.71698 ?  178 LEU A O   1 
ATOM   1410 C  CB  . LEU A 1 178 ? 16.35020  2.86400   46.69788  1.000 8.57751  ?  178 LEU A CB  1 
ATOM   1411 C  CG  . LEU A 1 178 ? 17.76216  3.15103   47.17090  1.000 14.19594 ?  178 LEU A CG  1 
ATOM   1412 C  CD1 . LEU A 1 178 ? 17.87224  2.44232   48.47319  1.000 18.46768 ?  178 LEU A CD1 1 
ATOM   1413 C  CD2 . LEU A 1 178 ? 18.73876  2.59800   46.20993  1.000 16.10297 ?  178 LEU A CD2 1 
ATOM   1414 N  N   . LEU A 1 179 ? 13.89879  2.19296   44.47665  1.000 8.62607  ?  179 LEU A N   1 
ATOM   1415 C  CA  . LEU A 1 179 ? 12.45738  2.15569   44.29463  1.000 9.74112  ?  179 LEU A CA  1 
ATOM   1416 C  C   . LEU A 1 179 ? 11.92249  0.73564   44.38412  1.000 14.48279 ?  179 LEU A C   1 
ATOM   1417 O  O   . LEU A 1 179 ? 12.60618  -0.23884  44.06459  1.000 9.60057  ?  179 LEU A O   1 
ATOM   1418 C  CB  . LEU A 1 179 ? 12.03729  2.79881   42.96584  1.000 13.14939 ?  179 LEU A CB  1 
ATOM   1419 C  CG  . LEU A 1 179 ? 12.52832  2.26255   41.63135  1.000 12.90045 ?  179 LEU A CG  1 
ATOM   1420 C  CD1 . LEU A 1 179 ? 11.52556  1.27807   41.03543  1.000 14.63491 ?  179 LEU A CD1 1 
ATOM   1421 C  CD2 . LEU A 1 179 ? 12.77065  3.39614   40.65316  1.000 11.85968 ?  179 LEU A CD2 1 
ATOM   1422 N  N   . ASP A 1 180 ? 10.67642  0.65049   44.81659  1.000 10.85859 ?  180 ASP A N   1 
ATOM   1423 C  CA  . ASP A 1 180 ? 9.87780   -0.56670  44.74464  1.000 15.63796 ?  180 ASP A CA  1 
ATOM   1424 C  C   . ASP A 1 180 ? 9.41067   -0.74409  43.30232  1.000 13.67017 ?  180 ASP A C   1 
ATOM   1425 O  O   . ASP A 1 180 ? 8.42456   -0.14273  42.87087  1.000 13.15483 ?  180 ASP A O   1 
ATOM   1426 C  CB  . ASP A 1 180 ? 8.72032   -0.44800  45.73143  1.000 13.09356 ?  180 ASP A CB  1 
ATOM   1427 C  CG  . ASP A 1 180 ? 7.61037   -1.46725  45.49396  1.000 17.44136 ?  180 ASP A CG  1 
ATOM   1428 O  OD1 . ASP A 1 180 ? 7.78366   -2.45408  44.72549  1.000 14.53458 ?  180 ASP A OD1 1 
ATOM   1429 O  OD2 . ASP A 1 180 ? 6.52948   -1.24163  46.08291  1.000 19.09580 -1 180 ASP A OD2 1 
ATOM   1430 N  N   . ASP A 1 181 ? 10.09222  -1.62087  42.56330  1.000 9.79514  ?  181 ASP A N   1 
ATOM   1431 C  CA  . ASP A 1 181 ? 9.84718   -1.78632  41.13776  1.000 14.47113 ?  181 ASP A CA  1 
ATOM   1432 C  C   . ASP A 1 181 ? 8.50167   -2.43905  40.85560  1.000 11.95413 ?  181 ASP A C   1 
ATOM   1433 O  O   . ASP A 1 181 ? 8.09387   -2.50492  39.68952  1.000 10.73723 ?  181 ASP A O   1 
ATOM   1434 C  CB  . ASP A 1 181 ? 10.99825  -2.60444  40.52843  1.000 10.11996 ?  181 ASP A CB  1 
ATOM   1435 C  CG  . ASP A 1 181 ? 10.98045  -2.63280  38.99466  1.000 9.91336  ?  181 ASP A CG  1 
ATOM   1436 O  OD1 . ASP A 1 181 ? 10.69977  -1.60085  38.36773  1.000 9.82354  ?  181 ASP A OD1 1 
ATOM   1437 O  OD2 . ASP A 1 181 ? 11.26378  -3.69329  38.40390  1.000 12.39482 -1 181 ASP A OD2 1 
ATOM   1438 N  N   . ARG A 1 182 ? 7.81165   -2.91732  41.88977  1.000 10.23537 ?  182 ARG A N   1 
ATOM   1439 C  CA  . ARG A 1 182 ? 6.51618   -3.56821  41.72644  1.000 12.07327 ?  182 ARG A CA  1 
ATOM   1440 C  C   . ARG A 1 182 ? 5.35179   -2.62805  42.01449  1.000 9.82517  ?  182 ARG A C   1 
ATOM   1441 O  O   . ARG A 1 182 ? 4.40907   -2.56064  41.22828  1.000 12.16566 ?  182 ARG A O   1 
ATOM   1442 C  CB  . ARG A 1 182 ? 6.43481   -4.79477  42.63923  1.000 8.75447  ?  182 ARG A CB  1 
ATOM   1443 C  CG  . ARG A 1 182 ? 7.38483   -5.89937  42.20613  1.000 14.40882 ?  182 ARG A CG  1 
ATOM   1444 C  CD  . ARG A 1 182 ? 7.40352   -7.05453  43.20036  1.000 15.97806 ?  182 ARG A CD  1 
ATOM   1445 N  NE  . ARG A 1 182 ? 8.13686   -8.19330  42.65199  1.000 21.45568 ?  182 ARG A NE  1 
ATOM   1446 C  CZ  . ARG A 1 182 ? 8.48638   -9.26516  43.34960  1.000 21.07602 ?  182 ARG A CZ  1 
ATOM   1447 N  NH1 . ARG A 1 182 ? 8.22803   -9.35818  44.64552  1.000 17.69636 ?  182 ARG A NH1 1 
ATOM   1448 N  NH2 . ARG A 1 182 ? 9.10882   -10.26659 42.73015  1.000 21.32919 ?  182 ARG A NH2 1 
ATOM   1449 N  N   . GLY A 1 183 ? 5.40737   -1.90213  43.13230  1.000 12.80888 ?  183 GLY A N   1 
ATOM   1450 C  CA  . GLY A 1 183 ? 4.35245   -0.97082  43.48289  1.000 14.24765 ?  183 GLY A CA  1 
ATOM   1451 C  C   . GLY A 1 183 ? 4.42260   0.34572   42.74869  1.000 16.06952 ?  183 GLY A C   1 
ATOM   1452 O  O   . GLY A 1 183 ? 3.41740   1.05697   42.68334  1.000 14.03977 ?  183 GLY A O   1 
ATOM   1453 N  N   . LEU A 1 184 ? 5.57369   0.67820   42.17107  1.000 11.52177 ?  184 LEU A N   1 
ATOM   1454 C  CA  . LEU A 1 184 ? 5.71613   1.90196   41.39220  1.000 10.38973 ?  184 LEU A CA  1 
ATOM   1455 C  C   . LEU A 1 184 ? 6.18788   1.58955   39.98362  1.000 11.51727 ?  184 LEU A C   1 
ATOM   1456 O  O   . LEU A 1 184 ? 6.94298   0.63383   39.76972  1.000 13.24395 ?  184 LEU A O   1 
ATOM   1457 C  CB  . LEU A 1 184 ? 6.72057   2.86653   42.03588  1.000 13.41771 ?  184 LEU A CB  1 
ATOM   1458 C  CG  . LEU A 1 184 ? 6.49355   3.29169   43.47249  1.000 17.40759 ?  184 LEU A CG  1 
ATOM   1459 C  CD1 . LEU A 1 184 ? 7.56502   4.31069   43.88998  1.000 9.22930  ?  184 LEU A CD1 1 
ATOM   1460 C  CD2 . LEU A 1 184 ? 5.09462   3.85995   43.61957  1.000 18.29282 ?  184 LEU A CD2 1 
ATOM   1461 N  N   . ALA A 1 185 ? 5.74647   2.40780   39.02329  1.000 9.17123  ?  185 ALA A N   1 
ATOM   1462 C  CA  . ALA A 1 185 ? 6.35598   2.44634   37.69885  1.000 9.68410  ?  185 ALA A CA  1 
ATOM   1463 C  C   . ALA A 1 185 ? 7.19211   3.71689   37.58037  1.000 10.16951 ?  185 ALA A C   1 
ATOM   1464 O  O   . ALA A 1 185 ? 7.06718   4.63269   38.39253  1.000 8.22032  ?  185 ALA A O   1 
ATOM   1465 C  CB  . ALA A 1 185 ? 5.29150   2.38226   36.59804  1.000 8.55615  ?  185 ALA A CB  1 
ATOM   1466 N  N   . HIS A 1 186 ? 8.06836   3.76268   36.57259  1.000 6.78609  ?  186 HIS A N   1 
ATOM   1467 C  CA  . HIS A 1 186 ? 8.89108   4.95418   36.39185  1.000 10.63833 ?  186 HIS A CA  1 
ATOM   1468 C  C   . HIS A 1 186 ? 9.15948   5.22314   34.92081  1.000 7.79092  ?  186 HIS A C   1 
ATOM   1469 O  O   . HIS A 1 186 ? 9.10353   4.32993   34.07311  1.000 7.72633  ?  186 HIS A O   1 
ATOM   1470 C  CB  . HIS A 1 186 ? 10.23589  4.88503   37.14092  1.000 7.65617  ?  186 HIS A CB  1 
ATOM   1471 C  CG  . HIS A 1 186 ? 11.15369  3.78835   36.68773  1.000 10.64485 ?  186 HIS A CG  1 
ATOM   1472 N  ND1 . HIS A 1 186 ? 10.92982  2.46167   36.98511  1.000 11.41930 ?  186 HIS A ND1 1 
ATOM   1473 C  CD2 . HIS A 1 186 ? 12.32172  3.82407   35.99981  1.000 11.52207 ?  186 HIS A CD2 1 
ATOM   1474 C  CE1 . HIS A 1 186 ? 11.91778  1.72955   36.49936  1.000 11.81401 ?  186 HIS A CE1 1 
ATOM   1475 N  NE2 . HIS A 1 186 ? 12.77020  2.53019   35.88893  1.000 13.12898 ?  186 HIS A NE2 1 
ATOM   1476 N  N   . ASP A 1 187 ? 9.43121   6.48763   34.63443  1.000 8.52679  ?  187 ASP A N   1 
ATOM   1477 C  CA  . ASP A 1 187 ? 10.12688  6.85376   33.41764  1.000 11.18207 ?  187 ASP A CA  1 
ATOM   1478 C  C   . ASP A 1 187 ? 11.04159  8.02886   33.74242  1.000 10.31212 ?  187 ASP A C   1 
ATOM   1479 O  O   . ASP A 1 187 ? 11.07818  8.52852   34.87374  1.000 10.47908 ?  187 ASP A O   1 
ATOM   1480 C  CB  . ASP A 1 187 ? 9.15645   7.16603   32.27160  1.000 7.76573  ?  187 ASP A CB  1 
ATOM   1481 C  CG  . ASP A 1 187 ? 8.50957   8.55000   32.39096  1.000 12.84680 ?  187 ASP A CG  1 
ATOM   1482 O  OD1 . ASP A 1 187 ? 8.38263   9.10713   33.51291  1.000 8.96077  ?  187 ASP A OD1 1 
ATOM   1483 O  OD2 . ASP A 1 187 ? 8.11626   9.07689   31.33282  1.000 12.66393 -1 187 ASP A OD2 1 
ATOM   1484 N  N   . VAL A 1 188 ? 11.81592  8.44817   32.75083  1.000 7.46208  ?  188 VAL A N   1 
ATOM   1485 C  CA  . VAL A 1 188 ? 12.79962  9.50932   32.93508  1.000 7.20500  ?  188 VAL A CA  1 
ATOM   1486 C  C   . VAL A 1 188 ? 12.78158  10.37284  31.68350  1.000 9.84453  ?  188 VAL A C   1 
ATOM   1487 O  O   . VAL A 1 188 ? 12.80526  9.83857   30.56924  1.000 7.82432  ?  188 VAL A O   1 
ATOM   1488 C  CB  . VAL A 1 188 ? 14.21937  8.94879   33.17418  1.000 8.53981  ?  188 VAL A CB  1 
ATOM   1489 C  CG1 . VAL A 1 188 ? 15.14790  10.06525  33.59932  1.000 5.66320  ?  188 VAL A CG1 1 
ATOM   1490 C  CG2 . VAL A 1 188 ? 14.21712  7.84363   34.21622  1.000 7.77691  ?  188 VAL A CG2 1 
ATOM   1491 N  N   . THR A 1 189 ? 12.73667  11.70017  31.85217  1.000 8.41679  ?  189 THR A N   1 
ATOM   1492 C  CA  . THR A 1 189 ? 12.69579  12.55108  30.66610  1.000 9.90537  ?  189 THR A CA  1 
ATOM   1493 C  C   . THR A 1 189 ? 14.03949  12.51726  29.95774  1.000 8.34451  ?  189 THR A C   1 
ATOM   1494 O  O   . THR A 1 189 ? 15.08136  12.23018  30.55806  1.000 8.34068  ?  189 THR A O   1 
ATOM   1495 C  CB  . THR A 1 189 ? 12.34445  14.01282  30.99315  1.000 7.97611  ?  189 THR A CB  1 
ATOM   1496 O  OG1 . THR A 1 189 ? 13.38353  14.59524  31.77662  1.000 8.83127  ?  189 THR A OG1 1 
ATOM   1497 C  CG2 . THR A 1 189 ? 11.00925  14.13033  31.71866  1.000 9.76361  ?  189 THR A CG2 1 
ATOM   1498 N  N   . ASP A 1 190 ? 14.00977  12.83950  28.66580  1.000 10.46697 ?  190 ASP A N   1 
ATOM   1499 C  CA  . ASP A 1 190 ? 15.21680  12.77420  27.85056  1.000 13.37843 ?  190 ASP A CA  1 
ATOM   1500 C  C   . ASP A 1 190 ? 16.32740  13.65353  28.41699  1.000 11.00244 ?  190 ASP A C   1 
ATOM   1501 O  O   . ASP A 1 190 ? 16.07726  14.71169  28.99149  1.000 8.13154  ?  190 ASP A O   1 
ATOM   1502 C  CB  . ASP A 1 190 ? 14.92296  13.21702  26.41743  1.000 12.10730 ?  190 ASP A CB  1 
ATOM   1503 C  CG  . ASP A 1 190 ? 14.12398  12.20860  25.64914  1.000 19.11178 ?  190 ASP A CG  1 
ATOM   1504 O  OD1 . ASP A 1 190 ? 13.91650  11.07419  26.15236  1.000 12.02286 ?  190 ASP A OD1 1 
ATOM   1505 O  OD2 . ASP A 1 190 ? 13.71852  12.56082  24.52163  1.000 19.54102 -1 190 ASP A OD2 1 
ATOM   1506 N  N   . VAL A 1 191 ? 17.56545  13.17152  28.26338  1.000 8.23717  ?  191 VAL A N   1 
ATOM   1507 C  CA  . VAL A 1 191 ? 18.76571  13.97916  28.40553  1.000 11.07375 ?  191 VAL A CA  1 
ATOM   1508 C  C   . VAL A 1 191 ? 18.79467  15.03499  27.30473  1.000 12.23097 ?  191 VAL A C   1 
ATOM   1509 O  O   . VAL A 1 191 ? 18.67663  14.71549  26.11539  1.000 12.08889 ?  191 VAL A O   1 
ATOM   1510 C  CB  . VAL A 1 191 ? 20.00308  13.06721  28.32124  1.000 5.89754  ?  191 VAL A CB  1 
ATOM   1511 C  CG1 . VAL A 1 191 ? 21.25626  13.87192  28.47992  1.000 13.71589 ?  191 VAL A CG1 1 
ATOM   1512 C  CG2 . VAL A 1 191 ? 19.95040  11.99440  29.36856  1.000 11.96306 ?  191 VAL A CG2 1 
ATOM   1513 N  N   . LEU A 1 192 ? 18.95072  16.29264  27.68699  1.000 11.95355 ?  192 LEU A N   1 
ATOM   1514 C  CA  . LEU A 1 192 ? 19.04664  17.38687  26.72878  1.000 10.95610 ?  192 LEU A CA  1 
ATOM   1515 C  C   . LEU A 1 192 ? 20.42235  18.03064  26.77745  1.000 12.00064 ?  192 LEU A C   1 
ATOM   1516 O  O   . LEU A 1 192 ? 21.02616  18.12940  27.84387  1.000 13.14087 ?  192 LEU A O   1 
ATOM   1517 C  CB  . LEU A 1 192 ? 18.01556  18.45758  27.01092  1.000 14.77592 ?  192 LEU A CB  1 
ATOM   1518 C  CG  . LEU A 1 192 ? 16.59368  17.92975  27.13085  1.000 17.82436 ?  192 LEU A CG  1 
ATOM   1519 C  CD1 . LEU A 1 192 ? 15.72685  19.08222  27.57501  1.000 20.14502 ?  192 LEU A CD1 1 
ATOM   1520 C  CD2 . LEU A 1 192 ? 16.12471  17.35176  25.80117  1.000 16.69933 ?  192 LEU A CD2 1 
ATOM   1521 N  N   . SER A 1 193 ? 20.91655  18.45753  25.62050  1.000 10.23532 ?  193 SER A N   1 
ATOM   1522 C  CA  . SER A 1 193 ? 22.11949  19.27471  25.58841  1.000 12.79605 ?  193 SER A CA  1 
ATOM   1523 C  C   . SER A 1 193 ? 21.87656  20.53600  26.39346  1.000 15.22943 ?  193 SER A C   1 
ATOM   1524 O  O   . SER A 1 193 ? 20.84312  21.19220  26.23698  1.000 14.73411 ?  193 SER A O   1 
ATOM   1525 C  CB  . SER A 1 193 ? 22.49304  19.64378  24.15529  1.000 16.58034 ?  193 SER A CB  1 
ATOM   1526 O  OG  . SER A 1 193 ? 23.58299  20.55048  24.15041  1.000 17.20608 ?  193 SER A OG  1 
ATOM   1527 N  N   . ALA A 1 194 ? 22.81984  20.87053  27.27093  1.000 16.62500 ?  194 ALA A N   1 
ATOM   1528 C  CA  . ALA A 1 194 ? 22.61527  22.04314  28.11241  1.000 17.25924 ?  194 ALA A CA  1 
ATOM   1529 C  C   . ALA A 1 194 ? 22.90978  23.35867  27.39038  1.000 21.69748 ?  194 ALA A C   1 
ATOM   1530 O  O   . ALA A 1 194 ? 22.38091  24.40304  27.79729  1.000 20.82303 ?  194 ALA A O   1 
ATOM   1531 C  CB  . ALA A 1 194 ? 23.47063  21.94190  29.37654  1.000 16.46397 ?  194 ALA A CB  1 
ATOM   1532 N  N   . ASP A 1 195 ? 23.72044  23.33387  26.32689  1.000 14.93502 ?  195 ASP A N   1 
ATOM   1533 C  CA  . ASP A 1 195 ? 24.11202  24.56809  25.65453  1.000 18.32297 ?  195 ASP A CA  1 
ATOM   1534 C  C   . ASP A 1 195 ? 24.12569  24.45550  24.13450  1.000 21.04089 ?  195 ASP A C   1 
ATOM   1535 O  O   . ASP A 1 195 ? 24.57652  25.39236  23.46668  1.000 22.55405 ?  195 ASP A O   1 
ATOM   1536 C  CB  . ASP A 1 195 ? 25.49824  25.01581  26.14449  1.000 20.18401 ?  195 ASP A CB  1 
ATOM   1537 C  CG  . ASP A 1 195 ? 26.61634  24.07379  25.70993  1.000 20.80879 ?  195 ASP A CG  1 
ATOM   1538 O  OD1 . ASP A 1 195 ? 26.34918  23.01408  25.08886  1.000 19.19971 ?  195 ASP A OD1 1 
ATOM   1539 O  OD2 . ASP A 1 195 ? 27.78766  24.41060  25.97518  1.000 25.63615 -1 195 ASP A OD2 1 
ATOM   1540 N  N   . GLY A 1 196 ? 23.69686  23.33571  23.56881  1.000 19.24669 ?  196 GLY A N   1 
ATOM   1541 C  CA  . GLY A 1 196 ? 23.80043  23.09440  22.14574  1.000 15.68594 ?  196 GLY A CA  1 
ATOM   1542 C  C   . GLY A 1 196 ? 24.90234  22.13825  21.75380  1.000 17.05403 ?  196 GLY A C   1 
ATOM   1543 O  O   . GLY A 1 196 ? 24.85195  21.57542  20.65175  1.000 22.55137 ?  196 GLY A O   1 
ATOM   1544 N  N   . GLY A 1 197 ? 25.89045  21.93922  22.61718  1.000 12.13479 ?  197 GLY A N   1 
ATOM   1545 C  CA  . GLY A 1 197 ? 26.98602  21.03757  22.34378  1.000 14.37902 ?  197 GLY A CA  1 
ATOM   1546 C  C   . GLY A 1 197 ? 26.75236  19.67493  22.95885  1.000 17.73769 ?  197 GLY A C   1 
ATOM   1547 O  O   . GLY A 1 197 ? 25.69667  19.39783  23.54371  1.000 13.64471 ?  197 GLY A O   1 
ATOM   1548 N  N   . PRO A 1 198 ? 27.74048  18.79495  22.82664  1.000 13.18638 ?  198 PRO A N   1 
ATOM   1549 C  CA  . PRO A 1 198 ? 27.59932  17.43741  23.35625  1.000 17.11890 ?  198 PRO A CA  1 
ATOM   1550 C  C   . PRO A 1 198 ? 27.63477  17.40746  24.87545  1.000 17.19875 ?  198 PRO A C   1 
ATOM   1551 O  O   . PRO A 1 198 ? 28.28465  18.22156  25.53353  1.000 14.03787 ?  198 PRO A O   1 
ATOM   1552 C  CB  . PRO A 1 198 ? 28.80014  16.69404  22.75792  1.000 15.63505 ?  198 PRO A CB  1 
ATOM   1553 C  CG  . PRO A 1 198 ? 29.80197  17.77072  22.46559  1.000 22.89006 ?  198 PRO A CG  1 
ATOM   1554 C  CD  . PRO A 1 198 ? 28.98423  18.96349  22.05307  1.000 21.26468 ?  198 PRO A CD  1 
ATOM   1555 N  N   . GLY A 1 199 ? 26.92107  16.43060  25.42454  1.000 10.27525 ?  199 GLY A N   1 
ATOM   1556 C  CA  . GLY A 1 199 ? 26.83917  16.22684  26.85438  1.000 12.37514 ?  199 GLY A CA  1 
ATOM   1557 C  C   . GLY A 1 199 ? 26.54311  14.76327  27.08136  1.000 10.93692 ?  199 GLY A C   1 
ATOM   1558 O  O   . GLY A 1 199 ? 26.21619  14.02601  26.14914  1.000 12.03390 ?  199 GLY A O   1 
ATOM   1559 N  N   . HIS A 1 200 ? 26.64583  14.34009  28.33627  1.000 10.28444 ?  200 HIS A N   1 
ATOM   1560 C  CA  . HIS A 1 200 ? 26.39056  12.92996  28.59944  1.000 9.33491  ?  200 HIS A CA  1 
ATOM   1561 C  C   . HIS A 1 200 ? 26.02051  12.74168  30.06142  1.000 9.43068  ?  200 HIS A C   1 
ATOM   1562 O  O   . HIS A 1 200 ? 26.26062  13.60884  30.90087  1.000 9.40077  ?  200 HIS A O   1 
ATOM   1563 C  CB  . HIS A 1 200 ? 27.59442  12.06399  28.23128  1.000 13.37242 ?  200 HIS A CB  1 
ATOM   1564 C  CG  . HIS A 1 200 ? 28.80706  12.33059  29.06721  1.000 14.43885 ?  200 HIS A CG  1 
ATOM   1565 N  ND1 . HIS A 1 200 ? 29.69669  13.35158  28.79113  1.000 17.64065 ?  200 HIS A ND1 1 
ATOM   1566 C  CD2 . HIS A 1 200 ? 29.29022  11.69355  30.16061  1.000 13.49216 ?  200 HIS A CD2 1 
ATOM   1567 C  CE1 . HIS A 1 200 ? 30.67293  13.33288  29.68441  1.000 13.86822 ?  200 HIS A CE1 1 
ATOM   1568 N  NE2 . HIS A 1 200 ? 30.44608  12.34153  30.52974  1.000 17.61898 ?  200 HIS A NE2 1 
ATOM   1569 N  N   . ARG A 1 201 ? 25.42642  11.58721  30.34786  1.000 10.29611 ?  201 ARG A N   1 
ATOM   1570 C  CA  . ARG A 1 201 ? 24.92312  11.26169  31.67665  1.000 8.06530  ?  201 ARG A CA  1 
ATOM   1571 C  C   . ARG A 1 201 ? 25.29981  9.81383   31.93978  1.000 8.38208  ?  201 ARG A C   1 
ATOM   1572 O  O   . ARG A 1 201 ? 24.87700  8.91125   31.20397  1.000 5.91027  ?  201 ARG A O   1 
ATOM   1573 C  CB  . ARG A 1 201 ? 23.40075  11.47132  31.75040  1.000 6.18378  ?  201 ARG A CB  1 
ATOM   1574 C  CG  . ARG A 1 201 ? 22.69474  11.11010  33.07637  1.000 7.54738  ?  201 ARG A CG  1 
ATOM   1575 C  CD  . ARG A 1 201 ? 21.19392  11.44250  32.94208  1.000 9.52563  ?  201 ARG A CD  1 
ATOM   1576 N  NE  . ARG A 1 201 ? 20.37949  11.06025  34.09196  1.000 7.88460  ?  201 ARG A NE  1 
ATOM   1577 C  CZ  . ARG A 1 201 ? 19.79657  9.87843   34.24303  1.000 8.11743  ?  201 ARG A CZ  1 
ATOM   1578 N  NH1 . ARG A 1 201 ? 20.02360  8.88208   33.39982  1.000 7.04378  ?  201 ARG A NH1 1 
ATOM   1579 N  NH2 . ARG A 1 201 ? 18.95241  9.69398   35.25881  1.000 7.34329  ?  201 ARG A NH2 1 
ATOM   1580 N  N   . ASP A 1 202 ? 26.09392  9.60703   32.97926  1.000 9.53648  ?  202 ASP A N   1 
ATOM   1581 C  CA  . ASP A 1 202 ? 26.66697  8.31489   33.31400  1.000 7.98379  ?  202 ASP A CA  1 
ATOM   1582 C  C   . ASP A 1 202 ? 26.01814  7.81957   34.59071  1.000 9.22354  ?  202 ASP A C   1 
ATOM   1583 O  O   . ASP A 1 202 ? 25.99578  8.53765   35.60367  1.000 6.68764  ?  202 ASP A O   1 
ATOM   1584 C  CB  . ASP A 1 202 ? 28.18521  8.41860   33.49117  1.000 11.24480 ?  202 ASP A CB  1 
ATOM   1585 C  CG  . ASP A 1 202 ? 28.88228  8.85054   32.21905  1.000 13.17753 ?  202 ASP A CG  1 
ATOM   1586 O  OD1 . ASP A 1 202 ? 28.24498  8.71440   31.14641  1.000 9.79583  ?  202 ASP A OD1 1 
ATOM   1587 O  OD2 . ASP A 1 202 ? 30.04223  9.33286   32.29580  1.000 9.24387  -1 202 ASP A OD2 1 
ATOM   1588 N  N   . ILE A 1 203 ? 25.49680  6.59246   34.53666  1.000 7.04442  ?  203 ILE A N   1 
ATOM   1589 C  CA  . ILE A 1 203 ? 24.66634  6.02699   35.59164  1.000 8.37820  ?  203 ILE A CA  1 
ATOM   1590 C  C   . ILE A 1 203 ? 24.98444  4.54581   35.73881  1.000 6.57527  ?  203 ILE A C   1 
ATOM   1591 O  O   . ILE A 1 203 ? 25.64280  3.93903   34.89785  1.000 9.07360  ?  203 ILE A O   1 
ATOM   1592 C  CB  . ILE A 1 203 ? 23.16012  6.19106   35.28682  1.000 9.57612  ?  203 ILE A CB  1 
ATOM   1593 C  CG1 . ILE A 1 203 ? 22.76572  5.28170   34.13734  1.000 6.23556  ?  203 ILE A CG1 1 
ATOM   1594 C  CG2 . ILE A 1 203 ? 22.82293  7.65123   34.92907  1.000 8.79233  ?  203 ILE A CG2 1 
ATOM   1595 C  CD1 . ILE A 1 203 ? 21.23260  5.28545   33.83294  1.000 7.99811  ?  203 ILE A CD1 1 
ATOM   1596 N  N   . VAL A 1 204 ? 24.48965  3.95209   36.81653  1.000 6.95047  ?  204 VAL A N   1 
ATOM   1597 C  CA  . VAL A 1 204 ? 24.40936  2.50238   36.90948  1.000 7.02836  ?  204 VAL A CA  1 
ATOM   1598 C  C   . VAL A 1 204 ? 23.01524  2.17123   37.41584  1.000 7.75418  ?  204 VAL A C   1 
ATOM   1599 O  O   . VAL A 1 204 ? 22.47497  2.87329   38.27709  1.000 7.26857  ?  204 VAL A O   1 
ATOM   1600 C  CB  . VAL A 1 204 ? 25.52376  1.89548   37.78491  1.000 5.34518  ?  204 VAL A CB  1 
ATOM   1601 C  CG1 . VAL A 1 204 ? 25.49549  2.45714   39.19947  1.000 11.03702 ?  204 VAL A CG1 1 
ATOM   1602 C  CG2 . VAL A 1 204 ? 25.41976  0.37895   37.81979  1.000 6.91543  ?  204 VAL A CG2 1 
ATOM   1603 N  N   . ILE A 1 205 ? 22.39073  1.19016   36.78413  1.000 6.75253  ?  205 ILE A N   1 
ATOM   1604 C  CA  . ILE A 1 205 ? 21.07605  0.68502   37.16186  1.000 5.53775  ?  205 ILE A CA  1 
ATOM   1605 C  C   . ILE A 1 205 ? 21.28074  -0.70341  37.72388  1.000 8.77734  ?  205 ILE A C   1 
ATOM   1606 O  O   . ILE A 1 205 ? 21.88282  -1.54642  37.05223  1.000 7.41262  ?  205 ILE A O   1 
ATOM   1607 C  CB  . ILE A 1 205 ? 20.13805  0.61128   35.94969  1.000 9.55373  ?  205 ILE A CB  1 
ATOM   1608 C  CG1 . ILE A 1 205 ? 20.02912  1.97981   35.28306  1.000 6.84178  ?  205 ILE A CG1 1 
ATOM   1609 C  CG2 . ILE A 1 205 ? 18.78621  0.02433   36.36478  1.000 9.16903  ?  205 ILE A CG2 1 
ATOM   1610 C  CD1 . ILE A 1 205 ? 19.46826  1.93566   33.83983  1.000 5.83235  ?  205 ILE A CD1 1 
ATOM   1611 N  N   . ILE A 1 206 ? 20.80619  -0.93952  38.95067  1.000 6.07126  ?  206 ILE A N   1 
ATOM   1612 C  CA  . ILE A 1 206 ? 20.89623  -2.24904  39.59529  1.000 7.58213  ?  206 ILE A CA  1 
ATOM   1613 C  C   . ILE A 1 206 ? 19.48458  -2.75532  39.86320  1.000 7.90087  ?  206 ILE A C   1 
ATOM   1614 O  O   . ILE A 1 206 ? 18.70746  -2.10043  40.57411  1.000 8.86364  ?  206 ILE A O   1 
ATOM   1615 C  CB  . ILE A 1 206 ? 21.70562  -2.21230  40.89914  1.000 7.35707  ?  206 ILE A CB  1 
ATOM   1616 C  CG1 . ILE A 1 206 ? 23.10836  -1.64767  40.64351  1.000 8.23285  ?  206 ILE A CG1 1 
ATOM   1617 C  CG2 . ILE A 1 206 ? 21.84288  -3.63286  41.45145  1.000 8.68636  ?  206 ILE A CG2 1 
ATOM   1618 C  CD1 . ILE A 1 206 ? 23.22247  -0.13932  40.96258  1.000 8.17061  ?  206 ILE A CD1 1 
ATOM   1619 N  N   . ALA A 1 207 ? 19.16043  -3.91891  39.30760  1.000 7.83779  ?  207 ALA A N   1 
ATOM   1620 C  CA  . ALA A 1 207 ? 17.83993  -4.52653  39.45354  1.000 8.46681  ?  207 ALA A CA  1 
ATOM   1621 C  C   . ALA A 1 207 ? 17.97747  -5.73804  40.36539  1.000 11.76283 ?  207 ALA A C   1 
ATOM   1622 O  O   . ALA A 1 207 ? 18.77626  -6.64596  40.08483  1.000 7.16184  ?  207 ALA A O   1 
ATOM   1623 C  CB  . ALA A 1 207 ? 17.24625  -4.92319  38.09709  1.000 3.91246  ?  207 ALA A CB  1 
ATOM   1624 N  N   . PHE A 1 208 ? 17.21413  -5.73226  41.45595  1.000 9.46751  ?  208 PHE A N   1 
ATOM   1625 C  CA  . PHE A 1 208 ? 17.30790  -6.72808  42.52118  1.000 8.57699  ?  208 PHE A CA  1 
ATOM   1626 C  C   . PHE A 1 208 ? 16.18890  -7.75362  42.39236  1.000 12.06852 ?  208 PHE A C   1 
ATOM   1627 O  O   . PHE A 1 208 ? 15.00751  -7.39167  42.34741  1.000 8.33734  ?  208 PHE A O   1 
ATOM   1628 C  CB  . PHE A 1 208 ? 17.19866  -6.07265  43.90644  1.000 9.33053  ?  208 PHE A CB  1 
ATOM   1629 C  CG  . PHE A 1 208 ? 18.30209  -5.11325  44.23477  1.000 8.54559  ?  208 PHE A CG  1 
ATOM   1630 C  CD1 . PHE A 1 208 ? 18.30846  -3.83022  43.72032  1.000 10.77666 ?  208 PHE A CD1 1 
ATOM   1631 C  CD2 . PHE A 1 208 ? 19.32017  -5.48818  45.10562  1.000 14.32446 ?  208 PHE A CD2 1 
ATOM   1632 C  CE1 . PHE A 1 208 ? 19.31629  -2.94219  44.04650  1.000 6.38585  ?  208 PHE A CE1 1 
ATOM   1633 C  CE2 . PHE A 1 208 ? 20.32561  -4.61273  45.42857  1.000 13.22747 ?  208 PHE A CE2 1 
ATOM   1634 C  CZ  . PHE A 1 208 ? 20.32443  -3.33043  44.89200  1.000 12.65318 ?  208 PHE A CZ  1 
ATOM   1635 N  N   . SER A 1 209 ? 16.55308  -9.02854  42.39649  1.000 9.57609  ?  209 SER A N   1 
ATOM   1636 C  CA  . SER A 1 209 ? 15.57785  -10.10975 42.41969  1.000 11.28815 ?  209 SER A CA  1 
ATOM   1637 C  C   . SER A 1 209 ? 16.09999  -11.17530 43.35869  1.000 12.86218 ?  209 SER A C   1 
ATOM   1638 O  O   . SER A 1 209 ? 17.31261  -11.37442 43.44716  1.000 8.27577  ?  209 SER A O   1 
ATOM   1639 C  CB  . SER A 1 209 ? 15.35390  -10.72069 41.03693  1.000 9.08969  ?  209 SER A CB  1 
ATOM   1640 O  OG  . SER A 1 209 ? 14.60624  -9.86422  40.19474  1.000 10.27225 ?  209 SER A OG  1 
ATOM   1641 N  N   . ARG A 1 210 ? 15.19012  -11.82623 44.08485  1.000 15.62857 ?  210 ARG A N   1 
ATOM   1642 C  CA  . ARG A 1 210 ? 15.57939  -12.97685 44.89335  1.000 12.93382 ?  210 ARG A CA  1 
ATOM   1643 C  C   . ARG A 1 210 ? 16.18864  -14.03218 43.99048  1.000 11.67488 ?  210 ARG A C   1 
ATOM   1644 O  O   . ARG A 1 210 ? 15.76252  -14.19770 42.84496  1.000 13.24003 ?  210 ARG A O   1 
ATOM   1645 C  CB  . ARG A 1 210 ? 14.36958  -13.54009 45.63324  1.000 12.80428 ?  210 ARG A CB  1 
ATOM   1646 C  CG  . ARG A 1 210 ? 13.85249  -12.54984 46.66277  1.000 16.41771 ?  210 ARG A CG  1 
ATOM   1647 C  CD  . ARG A 1 210 ? 12.44924  -12.84339 47.14622  1.000 14.77000 ?  210 ARG A CD  1 
ATOM   1648 N  NE  . ARG A 1 210 ? 11.96840  -11.66541 47.86014  1.000 13.86442 ?  210 ARG A NE  1 
ATOM   1649 C  CZ  . ARG A 1 210 ? 12.12798  -11.47400 49.15987  1.000 18.60528 ?  210 ARG A CZ  1 
ATOM   1650 N  NH1 . ARG A 1 210 ? 12.61227  -12.43119 49.94374  1.000 16.93209 ?  210 ARG A NH1 1 
ATOM   1651 N  NH2 . ARG A 1 210 ? 11.80896  -10.29062 49.68592  1.000 14.64496 ?  210 ARG A NH2 1 
ATOM   1652 N  N   . TRP A 1 211 ? 17.22763  -14.70903 44.49204  1.000 13.58858 ?  211 TRP A N   1 
ATOM   1653 C  CA  . TRP A 1 211 ? 17.86936  -15.76393 43.71664  1.000 12.12566 ?  211 TRP A CA  1 
ATOM   1654 C  C   . TRP A 1 211 ? 16.84595  -16.77553 43.22349  1.000 8.14470  ?  211 TRP A C   1 
ATOM   1655 O  O   . TRP A 1 211 ? 16.94008  -17.25603 42.08894  1.000 12.73566 ?  211 TRP A O   1 
ATOM   1656 C  CB  . TRP A 1 211 ? 18.96296  -16.45307 44.55496  1.000 11.81682 ?  211 TRP A CB  1 
ATOM   1657 C  CG  . TRP A 1 211 ? 19.71370  -17.51746 43.75656  1.000 17.25968 ?  211 TRP A CG  1 
ATOM   1658 C  CD1 . TRP A 1 211 ? 19.45017  -18.86339 43.72712  1.000 11.08803 ?  211 TRP A CD1 1 
ATOM   1659 C  CD2 . TRP A 1 211 ? 20.80018  -17.30981 42.84275  1.000 13.78162 ?  211 TRP A CD2 1 
ATOM   1660 N  NE1 . TRP A 1 211 ? 20.30300  -19.49142 42.87203  1.000 10.41178 ?  211 TRP A NE1 1 
ATOM   1661 C  CE2 . TRP A 1 211 ? 21.14759  -18.56843 42.31663  1.000 12.11631 ?  211 TRP A CE2 1 
ATOM   1662 C  CE3 . TRP A 1 211 ? 21.51941  -16.18436 42.42619  1.000 16.41977 ?  211 TRP A CE3 1 
ATOM   1663 C  CZ2 . TRP A 1 211 ? 22.17792  -18.73413 41.39419  1.000 15.65634 ?  211 TRP A CZ2 1 
ATOM   1664 C  CZ3 . TRP A 1 211 ? 22.54128  -16.35123 41.50553  1.000 17.05771 ?  211 TRP A CZ3 1 
ATOM   1665 C  CH2 . TRP A 1 211 ? 22.85933  -17.61440 40.99680  1.000 15.08117 ?  211 TRP A CH2 1 
ATOM   1666 N  N   . ALA A 1 212 ? 15.83932  -17.08168 44.04560  1.000 15.04355 ?  212 ALA A N   1 
ATOM   1667 C  CA  . ALA A 1 212 ? 14.76560  -17.98960 43.64153  1.000 16.65176 ?  212 ALA A CA  1 
ATOM   1668 C  C   . ALA A 1 212 ? 13.98714  -17.47733 42.44275  1.000 17.71821 ?  212 ALA A C   1 
ATOM   1669 O  O   . ALA A 1 212 ? 13.27008  -18.25833 41.81500  1.000 12.36793 ?  212 ALA A O   1 
ATOM   1670 C  CB  . ALA A 1 212 ? 13.78902  -18.23080 44.80239  1.000 11.04515 ?  212 ALA A CB  1 
ATOM   1671 N  N   . GLU A 1 213 ? 14.10460  -16.19126 42.10889  1.000 16.27366 ?  213 GLU A N   1 
ATOM   1672 C  CA  . GLU A 1 213 ? 13.44878  -15.63754 40.93214  1.000 17.75872 ?  213 GLU A CA  1 
ATOM   1673 C  C   . GLU A 1 213 ? 14.45835  -14.97420 40.00419  1.000 17.43805 ?  213 GLU A C   1 
ATOM   1674 O  O   . GLU A 1 213 ? 14.13893  -13.95592 39.38305  1.000 13.72416 ?  213 GLU A O   1 
ATOM   1675 C  CB  . GLU A 1 213 ? 12.37961  -14.61071 41.31833  1.000 18.49545 ?  213 GLU A CB  1 
ATOM   1676 C  CG  . GLU A 1 213 ? 11.39661  -14.96760 42.40824  1.000 25.56719 ?  213 GLU A CG  1 
ATOM   1677 C  CD  . GLU A 1 213 ? 10.51976  -13.76962 42.77897  1.000 30.24380 ?  213 GLU A CD  1 
ATOM   1678 O  OE1 . GLU A 1 213 ? 10.82791  -13.06936 43.76356  1.000 43.73380 ?  213 GLU A OE1 1 
ATOM   1679 O  OE2 . GLU A 1 213 ? 9.53177   -13.51854 42.05899  1.000 50.20380 -1 213 GLU A OE2 1 
ATOM   1680 N  N   . LYS A 1 214 ? 15.67775  -15.52495 39.91626  1.000 12.76479 ?  214 LYS A N   1 
ATOM   1681 C  CA  . LYS A 1 214 ? 16.78331  -14.81686 39.27851  1.000 13.62951 ?  214 LYS A CA  1 
ATOM   1682 C  C   . LYS A 1 214 ? 16.51918  -14.59622 37.79803  1.000 15.44115 ?  214 LYS A C   1 
ATOM   1683 O  O   . LYS A 1 214 ? 15.91417  -15.42767 37.12336  1.000 12.89776 ?  214 LYS A O   1 
ATOM   1684 C  CB  . LYS A 1 214 ? 18.10412  -15.58297 39.43733  1.000 11.55189 ?  214 LYS A CB  1 
ATOM   1685 C  CG  . LYS A 1 214 ? 18.09710  -17.02378 38.85451  1.000 15.37367 ?  214 LYS A CG  1 
ATOM   1686 C  CD  . LYS A 1 214 ? 19.36464  -17.79520 39.31839  1.000 16.43041 ?  214 LYS A CD  1 
ATOM   1687 C  CE  . LYS A 1 214 ? 19.51622  -19.19124 38.66200  1.000 16.43375 ?  214 LYS A CE  1 
ATOM   1688 N  NZ  . LYS A 1 214 ? 18.32042  -20.05790 38.85768  1.000 14.06513 ?  214 LYS A NZ  1 
ATOM   1689 N  N   . TRP A 1 215 ? 17.00307  -13.46558 37.29658  1.000 13.14218 ?  215 TRP A N   1 
ATOM   1690 C  CA  . TRP A 1 215 ? 16.97221  -13.11863 35.88094  1.000 11.72720 ?  215 TRP A CA  1 
ATOM   1691 C  C   . TRP A 1 215 ? 18.25040  -13.55708 35.17473  1.000 11.87945 ?  215 TRP A C   1 
ATOM   1692 O  O   . TRP A 1 215 ? 18.91860  -12.76563 34.51611  1.000 9.61044  ?  215 TRP A O   1 
ATOM   1693 C  CB  . TRP A 1 215 ? 16.77295  -11.61599 35.76115  1.000 14.13573 ?  215 TRP A CB  1 
ATOM   1694 C  CG  . TRP A 1 215 ? 15.37326  -11.17960 35.99576  1.000 13.38399 ?  215 TRP A CG  1 
ATOM   1695 C  CD1 . TRP A 1 215 ? 14.53298  -11.54182 37.02245  1.000 16.19096 ?  215 TRP A CD1 1 
ATOM   1696 C  CD2 . TRP A 1 215 ? 14.64005  -10.28362 35.17183  1.000 13.64857 ?  215 TRP A CD2 1 
ATOM   1697 N  NE1 . TRP A 1 215 ? 13.29838  -10.91905 36.86904  1.000 12.08252 ?  215 TRP A NE1 1 
ATOM   1698 C  CE2 . TRP A 1 215 ? 13.35203  -10.12970 35.74712  1.000 12.29979 ?  215 TRP A CE2 1 
ATOM   1699 C  CE3 . TRP A 1 215 ? 14.95373  -9.57120  34.00780  1.000 13.47804 ?  215 TRP A CE3 1 
ATOM   1700 C  CZ2 . TRP A 1 215 ? 12.37622  -9.30509  35.18187  1.000 11.69900 ?  215 TRP A CZ2 1 
ATOM   1701 C  CZ3 . TRP A 1 215 ? 13.97253  -8.74243  33.44673  1.000 12.22606 ?  215 TRP A CZ3 1 
ATOM   1702 C  CH2 . TRP A 1 215 ? 12.70278  -8.62979  34.03120  1.000 11.52134 ?  215 TRP A CH2 1 
ATOM   1703 N  N   . TYR A 1 216 ? 18.58687  -14.83943 35.29887  1.000 14.18762 ?  216 TYR A N   1 
ATOM   1704 C  CA  . TYR A 1 216 ? 19.88910  -15.35701 34.89026  1.000 10.78476 ?  216 TYR A CA  1 
ATOM   1705 C  C   . TYR A 1 216 ? 19.77628  -16.85876 34.66849  1.000 13.80383 ?  216 TYR A C   1 
ATOM   1706 O  O   . TYR A 1 216 ? 19.23125  -17.56920 35.51862  1.000 14.61484 ?  216 TYR A O   1 
ATOM   1707 C  CB  . TYR A 1 216 ? 20.92612  -15.06856 35.96988  1.000 13.24033 ?  216 TYR A CB  1 
ATOM   1708 C  CG  . TYR A 1 216 ? 22.32480  -15.57971 35.67485  1.000 16.75777 ?  216 TYR A CG  1 
ATOM   1709 C  CD1 . TYR A 1 216 ? 22.71758  -16.87869 36.02756  1.000 18.12091 ?  216 TYR A CD1 1 
ATOM   1710 C  CD2 . TYR A 1 216 ? 23.25768  -14.75758 35.06982  1.000 16.50786 ?  216 TYR A CD2 1 
ATOM   1711 C  CE1 . TYR A 1 216 ? 24.00893  -17.33776 35.76335  1.000 16.40214 ?  216 TYR A CE1 1 
ATOM   1712 C  CE2 . TYR A 1 216 ? 24.53714  -15.20108 34.80415  1.000 15.10298 ?  216 TYR A CE2 1 
ATOM   1713 C  CZ  . TYR A 1 216 ? 24.91836  -16.47842 35.14994  1.000 16.43570 ?  216 TYR A CZ  1 
ATOM   1714 O  OH  . TYR A 1 216 ? 26.21835  -16.86113 34.85647  1.000 14.59120 ?  216 TYR A OH  1 
ATOM   1715 N  N   . GLY A 1 217 ? 20.29640  -17.33724 33.55324  1.000 13.34713 ?  217 GLY A N   1 
ATOM   1716 C  CA  . GLY A 1 217 ? 20.32226  -18.76324 33.28807  1.000 20.62787 ?  217 GLY A CA  1 
ATOM   1717 C  C   . GLY A 1 217 ? 19.28486  -19.17406 32.25598  1.000 22.06660 ?  217 GLY A C   1 
ATOM   1718 O  O   . GLY A 1 217 ? 18.43567  -18.39310 31.82868  1.000 16.57068 ?  217 GLY A O   1 
ATOM   1719 N  N   . ASP A 1 218 ? 19.36685  -20.45496 31.86363  1.000 20.64833 ?  218 ASP A N   1 
ATOM   1720 C  CA  . ASP A 1 218 ? 18.59352  -20.93104 30.71374  1.000 20.56591 ?  218 ASP A CA  1 
ATOM   1721 C  C   . ASP A 1 218 ? 17.08507  -20.78905 30.91928  1.000 18.49102 ?  218 ASP A C   1 
ATOM   1722 O  O   . ASP A 1 218 ? 16.35357  -20.51386 29.96042  1.000 18.27831 ?  218 ASP A O   1 
ATOM   1723 C  CB  . ASP A 1 218 ? 18.92814  -22.39516 30.41450  1.000 26.09449 ?  218 ASP A CB  1 
ATOM   1724 C  CG  . ASP A 1 218 ? 20.39408  -22.61805 30.07043  1.000 30.15985 ?  218 ASP A CG  1 
ATOM   1725 O  OD1 . ASP A 1 218 ? 21.07283  -21.69626 29.56456  1.000 25.98395 ?  218 ASP A OD1 1 
ATOM   1726 O  OD2 . ASP A 1 218 ? 20.86067  -23.75093 30.30736  1.000 38.63010 -1 218 ASP A OD2 1 
ATOM   1727 N  N   . GLU A 1 219 ? 16.60095  -20.99270 32.14415  1.000 16.33679 ?  219 GLU A N   1 
ATOM   1728 C  CA  . GLU A 1 219 ? 15.16393  -20.94001 32.39218  1.000 17.13916 ?  219 GLU A CA  1 
ATOM   1729 C  C   . GLU A 1 219 ? 14.64965  -19.51095 32.29308  1.000 18.52047 ?  219 GLU A C   1 
ATOM   1730 O  O   . GLU A 1 219 ? 13.59185  -19.26333 31.70581  1.000 16.13166 ?  219 GLU A O   1 
ATOM   1731 C  CB  . GLU A 1 219 ? 14.84228  -21.53391 33.76698  1.000 20.86336 ?  219 GLU A CB  1 
ATOM   1732 C  CG  . GLU A 1 219 ? 13.33694  -21.62617 34.08250  1.000 24.56358 ?  219 GLU A CG  1 
ATOM   1733 C  CD  . GLU A 1 219 ? 13.02902  -21.87820 35.57359  1.000 26.81684 ?  219 GLU A CD  1 
ATOM   1734 O  OE1 . GLU A 1 219 ? 13.97043  -22.10280 36.36127  1.000 32.21198 ?  219 GLU A OE1 1 
ATOM   1735 O  OE2 . GLU A 1 219 ? 11.84176  -21.82617 35.96877  1.000 28.43748 -1 219 GLU A OE2 1 
ATOM   1736 N  N   . HIS A 1 220 ? 15.37788  -18.55254 32.87484  1.000 16.73853 ?  220 HIS A N   1 
ATOM   1737 C  CA  . HIS A 1 220 ? 14.99698  -17.15110 32.70042  1.000 14.39104 ?  220 HIS A CA  1 
ATOM   1738 C  C   . HIS A 1 220 ? 15.02777  -16.76827 31.23162  1.000 15.33745 ?  220 HIS A C   1 
ATOM   1739 O  O   . HIS A 1 220 ? 14.12475  -16.08328 30.73440  1.000 18.72238 ?  220 HIS A O   1 
ATOM   1740 C  CB  . HIS A 1 220 ? 15.91741  -16.21972 33.49306  1.000 13.50313 ?  220 HIS A CB  1 
ATOM   1741 C  CG  . HIS A 1 220 ? 15.87139  -14.79579 33.01312  1.000 13.74583 ?  220 HIS A CG  1 
ATOM   1742 N  ND1 . HIS A 1 220 ? 14.89427  -13.90946 33.41469  1.000 12.60883 ?  220 HIS A ND1 1 
ATOM   1743 C  CD2 . HIS A 1 220 ? 16.65468  -14.12143 32.13649  1.000 12.02327 ?  220 HIS A CD2 1 
ATOM   1744 C  CE1 . HIS A 1 220 ? 15.08817  -12.74561 32.82085  1.000 11.10162 ?  220 HIS A CE1 1 
ATOM   1745 N  NE2 . HIS A 1 220 ? 16.14823  -12.84900 32.03553  1.000 13.61694 ?  220 HIS A NE2 1 
ATOM   1746 N  N   . ASP A 1 221 ? 16.08663  -17.16507 30.52844  1.000 15.73438 ?  221 ASP A N   1 
ATOM   1747 C  CA  . ASP A 1 221 ? 16.19692  -16.80618 29.11977  1.000 18.38464 ?  221 ASP A CA  1 
ATOM   1748 C  C   . ASP A 1 221 ? 15.00463  -17.33728 28.33142  1.000 18.82205 ?  221 ASP A C   1 
ATOM   1749 O  O   . ASP A 1 221 ? 14.38141  -16.60564 27.55808  1.000 15.49624 ?  221 ASP A O   1 
ATOM   1750 C  CB  . ASP A 1 221 ? 17.51277  -17.33495 28.53526  1.000 16.12156 ?  221 ASP A CB  1 
ATOM   1751 C  CG  . ASP A 1 221 ? 18.72397  -16.53108 28.98189  1.000 16.45926 ?  221 ASP A CG  1 
ATOM   1752 O  OD1 . ASP A 1 221 ? 18.55451  -15.47225 29.62667  1.000 19.73454 ?  221 ASP A OD1 1 
ATOM   1753 O  OD2 . ASP A 1 221 ? 19.86036  -16.96377 28.70209  1.000 18.00788 -1 221 ASP A OD2 1 
ATOM   1754 N  N   . ALA A 1 222 ? 14.67518  -18.61766 28.51085  1.000 23.45454 ?  222 ALA A N   1 
ATOM   1755 C  CA  . ALA A 1 222 ? 13.53484  -19.18442 27.79985  1.000 20.66535 ?  222 ALA A CA  1 
ATOM   1756 C  C   . ALA A 1 222 ? 12.26934  -18.38486 28.07489  1.000 15.66893 ?  222 ALA A C   1 
ATOM   1757 O  O   . ALA A 1 222 ? 11.49349  -18.09111 27.15482  1.000 20.29949 ?  222 ALA A O   1 
ATOM   1758 C  CB  . ALA A 1 222 ? 13.35155  -20.64562 28.20222  1.000 18.19286 ?  222 ALA A CB  1 
ATOM   1759 N  N   . ALA A 1 223 ? 12.06178  -17.98606 29.33244  1.000 17.57309 ?  223 ALA A N   1 
ATOM   1760 C  CA  . ALA A 1 223 ? 10.85297  -17.24129 29.67115  1.000 20.84437 ?  223 ALA A CA  1 
ATOM   1761 C  C   . ALA A 1 223 ? 10.85425  -15.86597 29.01784  1.000 16.61485 ?  223 ALA A C   1 
ATOM   1762 O  O   . ALA A 1 223 ? 9.84373   -15.43788 28.44847  1.000 20.55804 ?  223 ALA A O   1 
ATOM   1763 C  CB  . ALA A 1 223 ? 10.71321  -17.11519 31.18834  1.000 21.21326 ?  223 ALA A CB  1 
ATOM   1764 N  N   . ALA A 1 224 ? 11.97850  -15.15432 29.09306  1.000 12.59720 ?  224 ALA A N   1 
ATOM   1765 C  CA  . ALA A 1 224 ? 12.00474  -13.79003 28.57541  1.000 16.05849 ?  224 ALA A CA  1 
ATOM   1766 C  C   . ALA A 1 224 ? 11.92140  -13.77314 27.05797  1.000 17.77672 ?  224 ALA A C   1 
ATOM   1767 O  O   . ALA A 1 224 ? 11.27153  -12.89796 26.47823  1.000 19.71596 ?  224 ALA A O   1 
ATOM   1768 C  CB  . ALA A 1 224 ? 13.26883  -13.06766 29.04408  1.000 13.11650 ?  224 ALA A CB  1 
ATOM   1769 N  N   . LEU A 1 225 ? 12.58527  -14.72593 26.39955  1.000 21.27074 ?  225 LEU A N   1 
ATOM   1770 C  CA  . LEU A 1 225 ? 12.54209  -14.85478 24.95082  1.000 20.64666 ?  225 LEU A CA  1 
ATOM   1771 C  C   . LEU A 1 225 ? 11.25090  -15.49237 24.45712  1.000 26.65134 ?  225 LEU A C   1 
ATOM   1772 O  O   . LEU A 1 225 ? 11.00543  -15.48562 23.24535  1.000 30.23661 ?  225 LEU A O   1 
ATOM   1773 C  CB  . LEU A 1 225 ? 13.72872  -15.68604 24.45169  1.000 16.60924 ?  225 LEU A CB  1 
ATOM   1774 C  CG  . LEU A 1 225 ? 15.18441  -15.16766 24.44882  1.000 31.40724 ?  225 LEU A CG  1 
ATOM   1775 C  CD1 . LEU A 1 225 ? 15.26820  -13.71226 24.11147  1.000 19.89169 ?  225 LEU A CD1 1 
ATOM   1776 C  CD2 . LEU A 1 225 ? 15.94369  -15.40231 25.72678  1.000 37.21829 ?  225 LEU A CD2 1 
ATOM   1777 N  N   . GLU A 1 226 ? 10.43700  -16.03711 25.35916  1.000 24.17355 ?  226 GLU A N   1 
ATOM   1778 C  CA  . GLU A 1 226 ? 9.23594   -16.79734 25.01350  1.000 27.51980 ?  226 GLU A CA  1 
ATOM   1779 C  C   . GLU A 1 226 ? 9.57660   -17.93966 24.05504  1.000 33.93821 ?  226 GLU A C   1 
ATOM   1780 O  O   . GLU A 1 226 ? 9.01206   -18.07703 22.96909  1.000 48.00373 ?  226 GLU A O   1 
ATOM   1781 C  CB  . GLU A 1 226 ? 8.16267   -15.87468 24.44182  1.000 27.78624 ?  226 GLU A CB  1 
ATOM   1782 C  CG  . GLU A 1 226 ? 7.68327   -14.86346 25.44154  1.000 28.79188 ?  226 GLU A CG  1 
ATOM   1783 C  CD  . GLU A 1 226 ? 6.59604   -13.96819 24.89304  1.000 41.24468 ?  226 GLU A CD  1 
ATOM   1784 O  OE1 . GLU A 1 226 ? 6.68378   -13.56254 23.71823  1.000 45.94451 ?  226 GLU A OE1 1 
ATOM   1785 O  OE2 . GLU A 1 226 ? 5.64344   -13.67129 25.63786  1.000 53.39914 -1 226 GLU A OE2 1 
ATOM   1786 N  N   . GLU A 1 227 ? 10.53680  -18.76022 24.48068  1.000 40.83284 ?  227 GLU A N   1 
ATOM   1787 C  CA  . GLU A 1 227 ? 11.05530  -19.83936 23.64465  1.000 46.27669 ?  227 GLU A CA  1 
ATOM   1788 C  C   . GLU A 1 227 ? 10.29527  -21.15627 23.83138  1.000 52.54469 ?  227 GLU A C   1 
ATOM   1789 O  O   . GLU A 1 227 ? 10.45626  -21.85157 24.83620  1.000 54.97395 ?  227 GLU A O   1 
ATOM   1790 C  CB  . GLU A 1 227 ? 12.54795  -20.04012 23.92247  1.000 40.93526 ?  227 GLU A CB  1 
ATOM   1791 C  CG  . GLU A 1 227 ? 13.41593  -18.99552 23.24205  1.000 44.37291 ?  227 GLU A CG  1 
ATOM   1792 C  CD  . GLU A 1 227 ? 14.90076  -19.28956 23.33860  1.000 53.33274 ?  227 GLU A CD  1 
ATOM   1793 O  OE1 . GLU A 1 227 ? 15.31463  -19.99623 24.28746  1.000 49.11165 ?  227 GLU A OE1 1 
ATOM   1794 O  OE2 . GLU A 1 227 ? 15.65307  -18.80840 22.45863  1.000 59.31552 ?  227 GLU A OE2 1 
ATOM   1795 N  N   . PRO B 1 2   ? -13.99439 3.71259   -1.68831  1.000 42.51033 ?  2   PRO B N   1 
ATOM   1796 C  CA  . PRO B 1 2   ? -13.14922 3.97675   -0.52182  1.000 45.54920 ?  2   PRO B CA  1 
ATOM   1797 C  C   . PRO B 1 2   ? -13.10699 2.84174   0.50397   1.000 38.42277 ?  2   PRO B C   1 
ATOM   1798 O  O   . PRO B 1 2   ? -13.43422 1.70292   0.17740   1.000 53.81380 ?  2   PRO B O   1 
ATOM   1799 C  CB  . PRO B 1 2   ? -13.77699 5.24082   0.05608   1.000 44.98133 ?  2   PRO B CB  1 
ATOM   1800 C  CG  . PRO B 1 2   ? -14.35991 5.97059   -1.20657  1.000 41.04665 ?  2   PRO B CG  1 
ATOM   1801 C  CD  . PRO B 1 2   ? -14.37445 4.97055   -2.35059  1.000 42.31395 ?  2   PRO B CD  1 
ATOM   1802 N  N   . LEU B 1 3   ? -12.69882 3.15857   1.73021   1.000 39.76599 ?  3   LEU B N   1 
ATOM   1803 C  CA  . LEU B 1 3   ? -12.42043 2.13254   2.73010   1.000 36.59646 ?  3   LEU B CA  1 
ATOM   1804 C  C   . LEU B 1 3   ? -13.68543 1.39745   3.15653   1.000 47.90409 ?  3   LEU B C   1 
ATOM   1805 O  O   . LEU B 1 3   ? -14.76002 1.99314   3.27336   1.000 52.90648 ?  3   LEU B O   1 
ATOM   1806 C  CB  . LEU B 1 3   ? -11.76661 2.76970   3.94790   1.000 32.98157 ?  3   LEU B CB  1 
ATOM   1807 C  CG  . LEU B 1 3   ? -10.49967 3.52720   3.57366   1.000 26.57513 ?  3   LEU B CG  1 
ATOM   1808 C  CD1 . LEU B 1 3   ? -9.89537  4.12418   4.82475   1.000 24.87268 ?  3   LEU B CD1 1 
ATOM   1809 C  CD2 . LEU B 1 3   ? -9.52843  2.58320   2.90212   1.000 27.10351 ?  3   LEU B CD2 1 
ATOM   1810 N  N   . GLY B 1 4   ? -13.53534 0.10308   3.44510   1.000 47.61380 ?  4   GLY B N   1 
ATOM   1811 C  CA  . GLY B 1 4   ? -14.67423 -0.77794  3.62668   1.000 54.71501 ?  4   GLY B CA  1 
ATOM   1812 C  C   . GLY B 1 4   ? -15.25774 -0.94800  5.01958   1.000 49.98354 ?  4   GLY B C   1 
ATOM   1813 O  O   . GLY B 1 4   ? -14.96494 -1.94097  5.69281   1.000 54.03933 ?  4   GLY B O   1 
ATOM   1814 N  N   . THR B 1 5   ? -16.09755 -0.00025  5.45488   1.000 50.11822 ?  5   THR B N   1 
ATOM   1815 C  CA  . THR B 1 5   ? -16.89172 -0.09139  6.68428   1.000 43.15063 ?  5   THR B CA  1 
ATOM   1816 C  C   . THR B 1 5   ? -16.05251 -0.11624  7.95514   1.000 40.21517 ?  5   THR B C   1 
ATOM   1817 O  O   . THR B 1 5   ? -16.31495 0.65237   8.87900   1.000 30.76590 ?  5   THR B O   1 
ATOM   1818 C  CB  . THR B 1 5   ? -17.81324 -1.32388  6.66726   1.000 57.45883 ?  5   THR B CB  1 
ATOM   1819 O  OG1 . THR B 1 5   ? -17.02919 -2.51824  6.79737   1.000 61.92740 ?  5   THR B OG1 1 
ATOM   1820 C  CG2 . THR B 1 5   ? -18.63889 -1.37854  5.37905   1.000 45.76000 ?  5   THR B CG2 1 
ATOM   1821 N  N   . GLU B 1 6   ? -15.05688 -0.99315  8.03936   1.000 32.39888 ?  6   GLU B N   1 
ATOM   1822 C  CA  . GLU B 1 6   ? -14.21930 -1.04162  9.22848   1.000 42.15394 ?  6   GLU B CA  1 
ATOM   1823 C  C   . GLU B 1 6   ? -12.91035 -0.27211  9.06604   1.000 31.39012 ?  6   GLU B C   1 
ATOM   1824 O  O   . GLU B 1 6   ? -12.01846 -0.39741  9.91168   1.000 27.85780 ?  6   GLU B O   1 
ATOM   1825 C  CB  . GLU B 1 6   ? -13.98256 -2.49654  9.65012   1.000 44.37702 ?  6   GLU B CB  1 
ATOM   1826 C  CG  . GLU B 1 6   ? -15.25784 -3.15752  10.21452  1.000 60.12489 ?  6   GLU B CG  1 
ATOM   1827 C  CD  . GLU B 1 6   ? -15.44921 -2.93876  11.72447  1.000 69.64666 ?  6   GLU B CD  1 
ATOM   1828 O  OE1 . GLU B 1 6   ? -16.05343 -1.92419  12.14942  1.000 66.59280 ?  6   GLU B OE1 1 
ATOM   1829 O  OE2 . GLU B 1 6   ? -14.97719 -3.80156  12.49578  1.000 81.71380 -1 6   GLU B OE2 1 
ATOM   1830 N  N   . GLY B 1 7   ? -12.79286 0.54117   8.02137   1.000 20.30579 ?  7   GLY B N   1 
ATOM   1831 C  CA  . GLY B 1 7   ? -11.77317 1.56996   7.98828   1.000 19.55675 ?  7   GLY B CA  1 
ATOM   1832 C  C   . GLY B 1 7   ? -10.41678 1.16030   7.46677   1.000 21.95281 ?  7   GLY B C   1 
ATOM   1833 O  O   . GLY B 1 7   ? -9.44229  1.89445   7.67633   1.000 18.18883 ?  7   GLY B O   1 
ATOM   1834 N  N   . PHE B 1 8   ? -10.31413 0.00855   6.81183   1.000 20.89103 ?  8   PHE B N   1 
ATOM   1835 C  CA  . PHE B 1 8   ? -9.09763  -0.37937  6.12444   1.000 18.13775 ?  8   PHE B CA  1 
ATOM   1836 C  C   . PHE B 1 8   ? -9.48629  -1.15512  4.88321   1.000 16.91190 ?  8   PHE B C   1 
ATOM   1837 O  O   . PHE B 1 8   ? -10.57127 -1.72732  4.81846   1.000 18.02428 ?  8   PHE B O   1 
ATOM   1838 C  CB  . PHE B 1 8   ? -8.19252  -1.23322  7.01456   1.000 13.19770 ?  8   PHE B CB  1 
ATOM   1839 C  CG  . PHE B 1 8   ? -8.66514  -2.63967  7.16864   1.000 13.80328 ?  8   PHE B CG  1 
ATOM   1840 C  CD1 . PHE B 1 8   ? -9.71414  -2.93904  8.02034   1.000 17.64742 ?  8   PHE B CD1 1 
ATOM   1841 C  CD2 . PHE B 1 8   ? -8.06374  -3.66794  6.46017   1.000 17.81495 ?  8   PHE B CD2 1 
ATOM   1842 C  CE1 . PHE B 1 8   ? -10.16143 -4.24635  8.17166   1.000 21.85079 ?  8   PHE B CE1 1 
ATOM   1843 C  CE2 . PHE B 1 8   ? -8.49996  -4.98754  6.61276   1.000 19.43458 ?  8   PHE B CE2 1 
ATOM   1844 C  CZ  . PHE B 1 8   ? -9.55182  -5.26886  7.47065   1.000 17.92619 ?  8   PHE B CZ  1 
ATOM   1845 N  N   . THR B 1 9   ? -8.60598  -1.15164  3.89082   1.000 16.55779 ?  9   THR B N   1 
ATOM   1846 C  CA  . THR B 1 9   ? -8.69630  -2.07741  2.76977   1.000 18.02423 ?  9   THR B CA  1 
ATOM   1847 C  C   . THR B 1 9   ? -7.29887  -2.58119  2.46390   1.000 17.45738 ?  9   THR B C   1 
ATOM   1848 O  O   . THR B 1 9   ? -6.31386  -1.86697  2.67113   1.000 15.46758 ?  9   THR B O   1 
ATOM   1849 C  CB  . THR B 1 9   ? -9.26357  -1.44707  1.47585   1.000 23.84061 ?  9   THR B CB  1 
ATOM   1850 O  OG1 . THR B 1 9   ? -10.45140 -0.70938  1.76626   1.000 29.12881 ?  9   THR B OG1 1 
ATOM   1851 C  CG2 . THR B 1 9   ? -9.60096  -2.52817  0.47368   1.000 18.43954 ?  9   THR B CG2 1 
ATOM   1852 N  N   . VAL B 1 10  ? -7.22311  -3.81258  1.95837   1.000 16.48271 ?  10  VAL B N   1 
ATOM   1853 C  CA  . VAL B 1 10  ? -5.99251  -4.38836  1.43275   1.000 17.36980 ?  10  VAL B CA  1 
ATOM   1854 C  C   . VAL B 1 10  ? -6.12095  -4.49182  -0.07946  1.000 21.30387 ?  10  VAL B C   1 
ATOM   1855 O  O   . VAL B 1 10  ? -7.09792  -5.05304  -0.58046  1.000 15.42007 ?  10  VAL B O   1 
ATOM   1856 C  CB  . VAL B 1 10  ? -5.69808  -5.77219  2.03430   1.000 17.99045 ?  10  VAL B CB  1 
ATOM   1857 C  CG1 . VAL B 1 10  ? -4.39192  -6.30533  1.44806   1.000 14.86371 ?  10  VAL B CG1 1 
ATOM   1858 C  CG2 . VAL B 1 10  ? -5.63493  -5.69683  3.56102   1.000 14.41698 ?  10  VAL B CG2 1 
ATOM   1859 N  N   . ILE B 1 11  ? -5.12107  -3.98821  -0.80303  1.000 15.24895 ?  11  ILE B N   1 
ATOM   1860 C  CA  . ILE B 1 11  ? -5.14704  -3.98984  -2.25762  1.000 22.37104 ?  11  ILE B CA  1 
ATOM   1861 C  C   . ILE B 1 11  ? -3.90346  -4.68050  -2.80447  1.000 23.10037 ?  11  ILE B C   1 
ATOM   1862 O  O   . ILE B 1 11  ? -2.85543  -4.76116  -2.15283  1.000 19.34945 ?  11  ILE B O   1 
ATOM   1863 C  CB  . ILE B 1 11  ? -5.24913  -2.55652  -2.82296  1.000 22.99780 ?  11  ILE B CB  1 
ATOM   1864 C  CG1 . ILE B 1 11  ? -4.01423  -1.74334  -2.41223  1.000 18.79915 ?  11  ILE B CG1 1 
ATOM   1865 C  CG2 . ILE B 1 11  ? -6.51148  -1.88999  -2.32690  1.000 22.56806 ?  11  ILE B CG2 1 
ATOM   1866 C  CD1 . ILE B 1 11  ? -3.90135  -0.39820  -3.10561  1.000 24.61868 ?  11  ILE B CD1 1 
ATOM   1867 N  N   . ASP B 1 12  ? -4.03450  -5.18074  -4.03101  1.000 23.16422 ?  12  ASP B N   1 
ATOM   1868 C  CA  . ASP B 1 12  ? -2.88271  -5.58582  -4.82562  1.000 27.57365 ?  12  ASP B CA  1 
ATOM   1869 C  C   . ASP B 1 12  ? -2.30848  -4.37487  -5.54236  1.000 23.24614 ?  12  ASP B C   1 
ATOM   1870 O  O   . ASP B 1 12  ? -3.04344  -3.49359  -5.99397  1.000 28.75494 ?  12  ASP B O   1 
ATOM   1871 C  CB  . ASP B 1 12  ? -3.25489  -6.65308  -5.85166  1.000 20.15682 ?  12  ASP B CB  1 
ATOM   1872 C  CG  . ASP B 1 12  ? -3.70723  -7.93038  -5.20573  1.000 23.41598 ?  12  ASP B CG  1 
ATOM   1873 O  OD1 . ASP B 1 12  ? -3.02058  -8.40848  -4.27294  1.000 29.86333 ?  12  ASP B OD1 1 
ATOM   1874 O  OD2 . ASP B 1 12  ? -4.76401  -8.44577  -5.62070  1.000 32.67315 -1 12  ASP B OD2 1 
ATOM   1875 N  N   . LEU B 1 13  ? -1.02501  -4.33631  -5.63656  1.000 23.51996 ?  13  LEU B N   1 
ATOM   1876 C  CA  . LEU B 1 13  ? -0.37676  -3.23217  -6.30816  1.000 24.05835 ?  13  LEU B CA  1 
ATOM   1877 C  C   . LEU B 1 13  ? -0.03510  -3.61585  -7.73273  1.000 26.43657 ?  13  LEU B C   1 
ATOM   1878 O  O   . LEU B 1 13  ? 0.14546   -4.79215  -8.05007  1.000 23.20130 ?  13  LEU B O   1 
ATOM   1879 C  CB  . LEU B 1 13  ? 0.90069   -2.84452  -5.57302  1.000 25.38318 ?  13  LEU B CB  1 
ATOM   1880 C  CG  . LEU B 1 13  ? 0.77652   -2.37955  -4.12569  1.000 24.19893 ?  13  LEU B CG  1 
ATOM   1881 C  CD1 . LEU B 1 13  ? 2.16994   -2.28148  -3.59231  1.000 22.08726 ?  13  LEU B CD1 1 
ATOM   1882 C  CD2 . LEU B 1 13  ? 0.08014   -1.03683  -4.07264  1.000 28.07061 ?  13  LEU B CD2 1 
ATOM   1883 N  N   . PRO B 1 14  ? 0.06855   -2.65006  -8.62244  1.000 29.58370 ?  14  PRO B N   1 
ATOM   1884 C  CA  . PRO B 1 14  ? 0.55268   -2.95053  -9.96534  1.000 36.30220 ?  14  PRO B CA  1 
ATOM   1885 C  C   . PRO B 1 14  ? 2.04350   -3.25056  -9.93440  1.000 35.06533 ?  14  PRO B C   1 
ATOM   1886 O  O   . PRO B 1 14  ? 2.74163   -3.03016  -8.94502  1.000 32.44457 ?  14  PRO B O   1 
ATOM   1887 C  CB  . PRO B 1 14  ? 0.25627   -1.67065  -10.75060 1.000 35.00967 ?  14  PRO B CB  1 
ATOM   1888 C  CG  . PRO B 1 14  ? 0.21371   -0.59698  -9.71664  1.000 37.13806 ?  14  PRO B CG  1 
ATOM   1889 C  CD  . PRO B 1 14  ? -0.31780  -1.23649  -8.46767  1.000 30.31829 ?  14  PRO B CD  1 
ATOM   1890 N  N   . GLU B 1 15  ? 2.51136   -3.79224  -11.04946 1.000 37.05178 ?  15  GLU B N   1 
ATOM   1891 C  CA  . GLU B 1 15  ? 3.93696   -3.91321  -11.31199 1.000 36.21043 ?  15  GLU B CA  1 
ATOM   1892 C  C   . GLU B 1 15  ? 4.62226   -2.55278  -11.18486 1.000 33.42307 ?  15  GLU B C   1 
ATOM   1893 O  O   . GLU B 1 15  ? 4.05146   -1.51495  -11.52837 1.000 25.22448 ?  15  GLU B O   1 
ATOM   1894 C  CB  . GLU B 1 15  ? 4.13671   -4.49567  -12.71644 1.000 40.37818 ?  15  GLU B CB  1 
ATOM   1895 C  CG  . GLU B 1 15  ? 3.65508   -3.58404  -13.88421 1.000 59.24911 ?  15  GLU B CG  1 
ATOM   1896 C  CD  . GLU B 1 15  ? 2.15742   -3.21168  -13.85397 1.000 59.00103 ?  15  GLU B CD  1 
ATOM   1897 O  OE1 . GLU B 1 15  ? 1.30232   -4.08738  -13.57241 1.000 50.97236 ?  15  GLU B OE1 1 
ATOM   1898 O  OE2 . GLU B 1 15  ? 1.84477   -2.02413  -14.11307 1.000 57.35392 -1 15  GLU B OE2 1 
ATOM   1899 N  N   . VAL B 1 16  ? 5.84782   -2.55380  -10.66967 1.000 33.63908 ?  16  VAL B N   1 
ATOM   1900 C  CA  . VAL B 1 16  ? 6.57911   -1.31639  -10.43240 1.000 30.79843 ?  16  VAL B CA  1 
ATOM   1901 C  C   . VAL B 1 16  ? 7.78081   -1.24222  -11.36854 1.000 30.01732 ?  16  VAL B C   1 
ATOM   1902 O  O   . VAL B 1 16  ? 8.32717   -2.25704  -11.81099 1.000 25.73515 ?  16  VAL B O   1 
ATOM   1903 C  CB  . VAL B 1 16  ? 7.01959   -1.18706  -8.95627  1.000 28.22027 ?  16  VAL B CB  1 
ATOM   1904 C  CG1 . VAL B 1 16  ? 5.81908   -1.33469  -8.03150  1.000 35.43290 ?  16  VAL B CG1 1 
ATOM   1905 C  CG2 . VAL B 1 16  ? 8.06935   -2.22731  -8.62206  1.000 27.68480 ?  16  VAL B CG2 1 
ATOM   1906 N  N   . ALA B 1 17  ? 8.20048   -0.00900  -11.65574 1.000 29.32069 ?  17  ALA B N   1 
ATOM   1907 C  CA  . ALA B 1 17  ? 9.35659   0.22838   -12.50825 1.000 30.45326 ?  17  ALA B CA  1 
ATOM   1908 C  C   . ALA B 1 17  ? 10.57648  -0.53531  -11.99660 1.000 29.48808 ?  17  ALA B C   1 
ATOM   1909 O  O   . ALA B 1 17  ? 10.72979  -0.74503  -10.78914 1.000 25.37457 ?  17  ALA B O   1 
ATOM   1910 C  CB  . ALA B 1 17  ? 9.67688   1.72187   -12.57472 1.000 31.99915 ?  17  ALA B CB  1 
ATOM   1911 N  N   . PRO B 1 18  ? 11.47093  -0.95052  -12.89791 1.000 29.56544 ?  18  PRO B N   1 
ATOM   1912 C  CA  . PRO B 1 18  ? 12.57372  -1.83268  -12.49003 1.000 26.68579 ?  18  PRO B CA  1 
ATOM   1913 C  C   . PRO B 1 18  ? 13.59822  -1.17963  -11.58482 1.000 30.61915 ?  18  PRO B C   1 
ATOM   1914 O  O   . PRO B 1 18  ? 14.42428  -1.90114  -11.01391 1.000 25.89089 ?  18  PRO B O   1 
ATOM   1915 C  CB  . PRO B 1 18  ? 13.20402  -2.25233  -13.82778 1.000 30.00414 ?  18  PRO B CB  1 
ATOM   1916 C  CG  . PRO B 1 18  ? 12.79866  -1.19646  -14.78991 1.000 32.03665 ?  18  PRO B CG  1 
ATOM   1917 C  CD  . PRO B 1 18  ? 11.42874  -0.75651  -14.35865 1.000 33.71750 ?  18  PRO B CD  1 
ATOM   1918 N  N   . ASP B 1 19  ? 13.59779  0.14370   -11.43545 1.000 26.33685 ?  19  ASP B N   1 
ATOM   1919 C  CA  . ASP B 1 19  ? 14.57686  0.75234   -10.54918 1.000 28.38632 ?  19  ASP B CA  1 
ATOM   1920 C  C   . ASP B 1 19  ? 14.15672  0.70885   -9.08522  1.000 23.57254 ?  19  ASP B C   1 
ATOM   1921 O  O   . ASP B 1 19  ? 15.00833  0.89566   -8.20588  1.000 22.54379 ?  19  ASP B O   1 
ATOM   1922 C  CB  . ASP B 1 19  ? 14.86855  2.20412   -10.96772 1.000 24.19739 ?  19  ASP B CB  1 
ATOM   1923 C  CG  . ASP B 1 19  ? 13.62360  3.07809   -11.00723 1.000 30.73008 ?  19  ASP B CG  1 
ATOM   1924 O  OD1 . ASP B 1 19  ? 12.49416  2.55171   -10.96663 1.000 29.03354 ?  19  ASP B OD1 1 
ATOM   1925 O  OD2 . ASP B 1 19  ? 13.77895  4.31206   -11.09181 1.000 33.44827 -1 19  ASP B OD2 1 
ATOM   1926 N  N   . ILE B 1 20  ? 12.88945  0.41569   -8.80261  1.000 23.31703 ?  20  ILE B N   1 
ATOM   1927 C  CA  . ILE B 1 20  ? 12.36567  0.62541   -7.45509  1.000 22.03143 ?  20  ILE B CA  1 
ATOM   1928 C  C   . ILE B 1 20  ? 12.94917  -0.38094  -6.47593  1.000 24.51724 ?  20  ILE B C   1 
ATOM   1929 O  O   . ILE B 1 20  ? 13.45847  0.00185   -5.41559  1.000 23.88268 ?  20  ILE B O   1 
ATOM   1930 C  CB  . ILE B 1 20  ? 10.82912  0.59375   -7.45568  1.000 24.18442 ?  20  ILE B CB  1 
ATOM   1931 C  CG1 . ILE B 1 20  ? 10.30245  1.87704   -8.10177  1.000 23.13627 ?  20  ILE B CG1 1 
ATOM   1932 C  CG2 . ILE B 1 20  ? 10.30878  0.47764   -6.03296  1.000 20.11597 ?  20  ILE B CG2 1 
ATOM   1933 C  CD1 . ILE B 1 20  ? 8.81441   1.96879   -8.15404  1.000 25.80167 ?  20  ILE B CD1 1 
ATOM   1934 N  N   . LEU B 1 21  ? 12.87154  -1.67938  -6.79651  1.000 20.07952 ?  21  LEU B N   1 
ATOM   1935 C  CA  . LEU B 1 21  ? 13.39275  -2.68025  -5.86902  1.000 21.09058 ?  21  LEU B CA  1 
ATOM   1936 C  C   . LEU B 1 21  ? 14.89381  -2.52480  -5.62912  1.000 18.01108 ?  21  LEU B C   1 
ATOM   1937 O  O   . LEU B 1 21  ? 15.30801  -2.53371  -4.45835  1.000 23.52986 ?  21  LEU B O   1 
ATOM   1938 C  CB  . LEU B 1 21  ? 13.01775  -4.09068  -6.34799  1.000 21.91686 ?  21  LEU B CB  1 
ATOM   1939 C  CG  . LEU B 1 21  ? 11.82522  -4.71304  -5.60800  1.000 23.72338 ?  21  LEU B CG  1 
ATOM   1940 C  CD1 . LEU B 1 21  ? 10.56409  -3.86670  -5.75529  1.000 25.69266 ?  21  LEU B CD1 1 
ATOM   1941 C  CD2 . LEU B 1 21  ? 11.55246  -6.15747  -6.02268  1.000 16.54534 ?  21  LEU B CD2 1 
ATOM   1942 N  N   . PRO B 1 22  ? 15.74766  -2.32999  -6.64129  1.000 20.22549 ?  22  PRO B N   1 
ATOM   1943 C  CA  . PRO B 1 22  ? 17.17323  -2.15278  -6.34324  1.000 23.44075 ?  22  PRO B CA  1 
ATOM   1944 C  C   . PRO B 1 22  ? 17.47649  -0.92489  -5.51468  1.000 20.55901 ?  22  PRO B C   1 
ATOM   1945 O  O   . PRO B 1 22  ? 18.53239  -0.87631  -4.86543  1.000 18.92798 ?  22  PRO B O   1 
ATOM   1946 C  CB  . PRO B 1 22  ? 17.80914  -2.04734  -7.73773  1.000 23.85944 ?  22  PRO B CB  1 
ATOM   1947 C  CG  . PRO B 1 22  ? 16.88037  -2.71085  -8.61850  1.000 23.52435 ?  22  PRO B CG  1 
ATOM   1948 C  CD  . PRO B 1 22  ? 15.52594  -2.38957  -8.09459  1.000 24.99963 ?  22  PRO B CD  1 
ATOM   1949 N  N   . SER B 1 23  ? 16.60000  0.08054   -5.51980  1.000 23.17563 ?  23  SER B N   1 
ATOM   1950 C  CA  . SER B 1 23  ? 16.93456  1.30730   -4.80541  1.000 22.78642 ?  23  SER B CA  1 
ATOM   1951 C  C   . SER B 1 23  ? 17.01386  1.09203   -3.30196  1.000 20.88368 ?  23  SER B C   1 
ATOM   1952 O  O   . SER B 1 23  ? 17.65780  1.88902   -2.60925  1.000 19.76875 ?  23  SER B O   1 
ATOM   1953 C  CB  . SER B 1 23  ? 15.92588  2.41400   -5.12371  1.000 19.99498 ?  23  SER B CB  1 
ATOM   1954 O  OG  . SER B 1 23  ? 14.59511  2.01963   -4.80839  1.000 21.24322 ?  23  SER B OG  1 
ATOM   1955 N  N   . TYR B 1 24  ? 16.38483  0.03356   -2.78168  1.000 20.71201 ?  24  TYR B N   1 
ATOM   1956 C  CA  . TYR B 1 24  ? 16.41905  -0.19754  -1.34323  1.000 19.98025 ?  24  TYR B CA  1 
ATOM   1957 C  C   . TYR B 1 24  ? 17.82960  -0.50748  -0.86263  1.000 19.75385 ?  24  TYR B C   1 
ATOM   1958 O  O   . TYR B 1 24  ? 18.17286  -0.19030  0.28258   1.000 23.29187 ?  24  TYR B O   1 
ATOM   1959 C  CB  . TYR B 1 24  ? 15.44204  -1.31404  -0.96805  1.000 15.36935 ?  24  TYR B CB  1 
ATOM   1960 C  CG  . TYR B 1 24  ? 14.01247  -0.82920  -0.94438  1.000 17.54717 ?  24  TYR B CG  1 
ATOM   1961 C  CD1 . TYR B 1 24  ? 13.25461  -0.78045  -2.10785  1.000 14.60889 ?  24  TYR B CD1 1 
ATOM   1962 C  CD2 . TYR B 1 24  ? 13.43006  -0.38212  0.24440   1.000 11.77981 ?  24  TYR B CD2 1 
ATOM   1963 C  CE1 . TYR B 1 24  ? 11.95431  -0.31831  -2.09072  1.000 16.52324 ?  24  TYR B CE1 1 
ATOM   1964 C  CE2 . TYR B 1 24  ? 12.13140  0.07322   0.27524   1.000 9.13031  ?  24  TYR B CE2 1 
ATOM   1965 C  CZ  . TYR B 1 24  ? 11.39721  0.11099   -0.89756  1.000 13.38721 ?  24  TYR B CZ  1 
ATOM   1966 O  OH  . TYR B 1 24  ? 10.09273  0.55390   -0.87490  1.000 15.52580 ?  24  TYR B OH  1 
ATOM   1967 N  N   . ASP B 1 25  ? 18.66261  -1.09726  -1.72367  1.000 21.15054 ?  25  ASP B N   1 
ATOM   1968 C  CA  . ASP B 1 25  ? 20.06754  -1.30627  -1.39128  1.000 18.05642 ?  25  ASP B CA  1 
ATOM   1969 C  C   . ASP B 1 25  ? 20.82399  -0.00508  -1.14298  1.000 23.51065 ?  25  ASP B C   1 
ATOM   1970 O  O   . ASP B 1 25  ? 21.83176  -0.01850  -0.43075  1.000 25.00836 ?  25  ASP B O   1 
ATOM   1971 C  CB  . ASP B 1 25  ? 20.75699  -2.07788  -2.50902  1.000 23.36607 ?  25  ASP B CB  1 
ATOM   1972 C  CG  . ASP B 1 25  ? 20.23002  -3.48204  -2.64448  1.000 29.94052 ?  25  ASP B CG  1 
ATOM   1973 O  OD1 . ASP B 1 25  ? 19.81580  -4.05301  -1.61555  1.000 27.78558 ?  25  ASP B OD1 1 
ATOM   1974 O  OD2 . ASP B 1 25  ? 20.21083  -4.00990  -3.77066  1.000 32.48380 -1 25  ASP B OD2 1 
ATOM   1975 N  N   . ARG B 1 26  ? 20.37217  1.11026   -1.71074  1.000 21.13039 ?  26  ARG B N   1 
ATOM   1976 C  CA  . ARG B 1 26  ? 21.07944  2.37871   -1.60787  1.000 20.10680 ?  26  ARG B CA  1 
ATOM   1977 C  C   . ARG B 1 26  ? 20.47026  3.30046   -0.55351  1.000 21.18281 ?  26  ARG B C   1 
ATOM   1978 O  O   . ARG B 1 26  ? 20.78771  4.49463   -0.52431  1.000 24.94615 ?  26  ARG B O   1 
ATOM   1979 C  CB  . ARG B 1 26  ? 21.10730  3.08288   -2.96629  1.000 24.30362 ?  26  ARG B CB  1 
ATOM   1980 C  CG  . ARG B 1 26  ? 21.64591  2.23293   -4.11244  1.000 28.51267 ?  26  ARG B CG  1 
ATOM   1981 C  CD  . ARG B 1 26  ? 21.90839  3.07011   -5.36780  1.000 28.28384 ?  26  ARG B CD  1 
ATOM   1982 N  NE  . ARG B 1 26  ? 20.70671  3.74174   -5.85217  1.000 31.22783 ?  26  ARG B NE  1 
ATOM   1983 C  CZ  . ARG B 1 26  ? 19.78616  3.17912   -6.62667  1.000 36.30712 ?  26  ARG B CZ  1 
ATOM   1984 N  NH1 . ARG B 1 26  ? 19.89190  1.91751   -7.02041  1.000 28.30114 ?  26  ARG B NH1 1 
ATOM   1985 N  NH2 . ARG B 1 26  ? 18.72760  3.89908   -7.00912  1.000 33.86793 ?  26  ARG B NH2 1 
ATOM   1986 N  N   . CYS B 1 27  ? 19.57804  2.77069   0.31486   1.000 20.99347 ?  27  CYS B N   1 
ATOM   1987 C  CA  . CYS B 1 27  ? 19.00033  3.58808   1.38169   1.000 17.71689 ?  27  CYS B CA  1 
ATOM   1988 C  C   . CYS B 1 27  ? 19.93626  3.59536   2.58471   1.000 18.58245 ?  27  CYS B C   1 
ATOM   1989 O  O   . CYS B 1 27  ? 20.31895  2.52283   3.06902   1.000 20.57748 ?  27  CYS B O   1 
ATOM   1990 C  CB  . CYS B 1 27  ? 17.63106  3.06045   1.79538   1.000 14.13576 ?  27  CYS B CB  1 
ATOM   1991 S  SG  . CYS B 1 27  ? 16.32818  3.29802   0.55786   1.000 19.33338 ?  27  CYS B SG  1 
ATOM   1992 N  N   . PRO B 1 28  ? 20.31587  4.75705   3.10544   1.000 18.17830 ?  28  PRO B N   1 
ATOM   1993 C  CA  . PRO B 1 28  ? 21.25317  4.78045   4.22909   1.000 20.65622 ?  28  PRO B CA  1 
ATOM   1994 C  C   . PRO B 1 28  ? 20.57182  4.39960   5.53168   1.000 19.68438 ?  28  PRO B C   1 
ATOM   1995 O  O   . PRO B 1 28  ? 19.35095  4.45067   5.66801   1.000 18.48397 ?  28  PRO B O   1 
ATOM   1996 C  CB  . PRO B 1 28  ? 21.74659  6.23089   4.26151   1.000 19.51863 ?  28  PRO B CB  1 
ATOM   1997 C  CG  . PRO B 1 28  ? 20.67147  7.02176   3.61806   1.000 20.57787 ?  28  PRO B CG  1 
ATOM   1998 C  CD  . PRO B 1 28  ? 19.94076  6.11226   2.65646   1.000 20.71155 ?  28  PRO B CD  1 
ATOM   1999 N  N   . VAL B 1 29  ? 21.39970  3.99217   6.49364   1.000 18.08493 ?  29  VAL B N   1 
ATOM   2000 C  CA  . VAL B 1 29  ? 20.87206  3.53641   7.77233   1.000 17.84391 ?  29  VAL B CA  1 
ATOM   2001 C  C   . VAL B 1 29  ? 20.06047  4.65812   8.40747   1.000 20.73459 ?  29  VAL B C   1 
ATOM   2002 O  O   . VAL B 1 29  ? 20.34751  5.85050   8.23069   1.000 12.71175 ?  29  VAL B O   1 
ATOM   2003 C  CB  . VAL B 1 29  ? 22.01325  3.05447   8.68976   1.000 18.48029 ?  29  VAL B CB  1 
ATOM   2004 C  CG1 . VAL B 1 29  ? 22.88289  4.21600   9.15831   1.000 25.26876 ?  29  VAL B CG1 1 
ATOM   2005 C  CG2 . VAL B 1 29  ? 21.47303  2.24858   9.89319   1.000 20.35493 ?  29  VAL B CG2 1 
ATOM   2006 N  N   . ASP B 1 30  ? 19.01157  4.26878   9.12121   1.000 13.84855 ?  30  ASP B N   1 
ATOM   2007 C  CA  . ASP B 1 30  ? 18.17554  5.19725   9.86845   1.000 14.85002 ?  30  ASP B CA  1 
ATOM   2008 C  C   . ASP B 1 30  ? 18.82074  5.40674   11.23352  1.000 17.76149 ?  30  ASP B C   1 
ATOM   2009 O  O   . ASP B 1 30  ? 18.83519  4.49070   12.06368  1.000 13.92076 ?  30  ASP B O   1 
ATOM   2010 C  CB  . ASP B 1 30  ? 16.76670  4.62017   9.97780   1.000 13.71800 ?  30  ASP B CB  1 
ATOM   2011 C  CG  . ASP B 1 30  ? 15.75632  5.59074   10.58328  1.000 16.66437 ?  30  ASP B CG  1 
ATOM   2012 O  OD1 . ASP B 1 30  ? 16.15130  6.56374   11.24482  1.000 11.29651 ?  30  ASP B OD1 1 
ATOM   2013 O  OD2 . ASP B 1 30  ? 14.53971  5.34620   10.41456  1.000 19.26923 -1 30  ASP B OD2 1 
ATOM   2014 N  N   . ASP B 1 31  ? 19.37712  6.60032   11.46329  1.000 14.94001 ?  31  ASP B N   1 
ATOM   2015 C  CA  . ASP B 1 31  ? 20.07143  6.87153   12.72339  1.000 16.81337 ?  31  ASP B CA  1 
ATOM   2016 C  C   . ASP B 1 31  ? 19.14403  7.01800   13.90761  1.000 13.69117 ?  31  ASP B C   1 
ATOM   2017 O  O   . ASP B 1 31  ? 19.62704  7.05703   15.04342  1.000 17.52060 ?  31  ASP B O   1 
ATOM   2018 C  CB  . ASP B 1 31  ? 20.89468  8.14789   12.62225  1.000 22.51983 ?  31  ASP B CB  1 
ATOM   2019 C  CG  . ASP B 1 31  ? 22.03775  8.00351   11.68340  1.000 25.88471 ?  31  ASP B CG  1 
ATOM   2020 O  OD1 . ASP B 1 31  ? 22.56635  6.87603   11.59482  1.000 30.84380 ?  31  ASP B OD1 1 
ATOM   2021 O  OD2 . ASP B 1 31  ? 22.38935  8.99846   11.01892  1.000 33.06190 -1 31  ASP B OD2 1 
ATOM   2022 N  N   . TYR B 1 32  ? 17.83256  7.10644   13.68856  1.000 13.44411 ?  32  TYR B N   1 
ATOM   2023 C  CA  . TYR B 1 32  ? 16.93293  7.49034   14.76508  1.000 17.96965 ?  32  TYR B CA  1 
ATOM   2024 C  C   . TYR B 1 32  ? 16.00773  6.38569   15.24084  1.000 16.24235 ?  32  TYR B C   1 
ATOM   2025 O  O   . TYR B 1 32  ? 15.45289  6.50528   16.34120  1.000 11.42700 ?  32  TYR B O   1 
ATOM   2026 C  CB  . TYR B 1 32  ? 16.06400  8.67608   14.32951  1.000 15.69373 ?  32  TYR B CB  1 
ATOM   2027 C  CG  . TYR B 1 32  ? 16.84661  9.85094   13.77932  1.000 15.78796 ?  32  TYR B CG  1 
ATOM   2028 C  CD1 . TYR B 1 32  ? 17.08472  9.96916   12.41478  1.000 13.70835 ?  32  TYR B CD1 1 
ATOM   2029 C  CD2 . TYR B 1 32  ? 17.33758  10.84530  14.62701  1.000 15.73250 ?  32  TYR B CD2 1 
ATOM   2030 C  CE1 . TYR B 1 32  ? 17.79686  11.05189  11.89557  1.000 18.53436 ?  32  TYR B CE1 1 
ATOM   2031 C  CE2 . TYR B 1 32  ? 18.03271  11.93338  14.12297  1.000 15.75670 ?  32  TYR B CE2 1 
ATOM   2032 C  CZ  . TYR B 1 32  ? 18.26465  12.03261  12.74704  1.000 20.44086 ?  32  TYR B CZ  1 
ATOM   2033 O  OH  . TYR B 1 32  ? 18.96363  13.11528  12.22863  1.000 16.65108 ?  32  TYR B OH  1 
ATOM   2034 N  N   . MET B 1 33  ? 15.80683  5.33836   14.44387  1.000 14.55908 ?  33  MET B N   1 
ATOM   2035 C  CA  A MET B 1 33  ? 14.83101  4.30111   14.74644  0.718 13.93357 ?  33  MET B CA  1 
ATOM   2036 C  CA  B MET B 1 33  ? 14.85842  4.29857   14.79577  0.282 13.93741 ?  33  MET B CA  1 
ATOM   2037 C  C   . MET B 1 33  ? 15.35053  2.95945   14.27698  1.000 10.62672 ?  33  MET B C   1 
ATOM   2038 O  O   . MET B 1 33  ? 15.99086  2.87262   13.23069  1.000 15.36413 ?  33  MET B O   1 
ATOM   2039 C  CB  A MET B 1 33  ? 13.48761  4.56806   14.05711  0.718 14.48057 ?  33  MET B CB  1 
ATOM   2040 C  CB  B MET B 1 33  ? 13.46574  4.59603   14.23291  0.282 14.61340 ?  33  MET B CB  1 
ATOM   2041 C  CG  A MET B 1 33  ? 12.78712  5.79085   14.57617  0.718 17.51203 ?  33  MET B CG  1 
ATOM   2042 C  CG  B MET B 1 33  ? 12.34054  4.13299   15.12736  0.282 17.57370 ?  33  MET B CG  1 
ATOM   2043 S  SD  A MET B 1 33  ? 12.09961  5.43529   16.18602  0.718 29.88095 ?  33  MET B SD  1 
ATOM   2044 S  SD  B MET B 1 33  ? 11.24653  5.49577   15.55790  0.282 24.06380 ?  33  MET B SD  1 
ATOM   2045 C  CE  A MET B 1 33  ? 10.58933  4.58151   15.69174  0.718 20.64640 ?  33  MET B CE  1 
ATOM   2046 C  CE  B MET B 1 33  ? 10.52513  5.82507   13.96371  0.282 16.86559 ?  33  MET B CE  1 
ATOM   2047 N  N   . GLY B 1 34  ? 15.03365  1.91121   15.03723  1.000 14.62561 ?  34  GLY B N   1 
ATOM   2048 C  CA  . GLY B 1 34  ? 15.35189  0.56152   14.64612  1.000 13.35685 ?  34  GLY B CA  1 
ATOM   2049 C  C   . GLY B 1 34  ? 16.72359  0.08938   15.06521  1.000 15.16771 ?  34  GLY B C   1 
ATOM   2050 O  O   . GLY B 1 34  ? 17.07663  -1.06153  14.76895  1.000 12.04764 ?  34  GLY B O   1 
ATOM   2051 N  N   . ASN B 1 35  ? 17.50278  0.94407   15.72863  1.000 10.45835 ?  35  ASN B N   1 
ATOM   2052 C  CA  . ASN B 1 35  ? 18.76985  0.56456   16.34071  1.000 15.19446 ?  35  ASN B CA  1 
ATOM   2053 C  C   . ASN B 1 35  ? 19.64174  -0.22153  15.37062  1.000 14.33764 ?  35  ASN B C   1 
ATOM   2054 O  O   . ASN B 1 35  ? 20.11374  -1.32285  15.66278  1.000 16.60158 ?  35  ASN B O   1 
ATOM   2055 C  CB  . ASN B 1 35  ? 18.51058  -0.20317  17.63603  1.000 13.38467 ?  35  ASN B CB  1 
ATOM   2056 C  CG  . ASN B 1 35  ? 18.01186  0.71842   18.73256  1.000 11.81071 ?  35  ASN B CG  1 
ATOM   2057 O  OD1 . ASN B 1 35  ? 18.80358  1.36989   19.38915  1.000 10.26338 ?  35  ASN B OD1 1 
ATOM   2058 N  ND2 . ASN B 1 35  ? 16.70119  0.79284   18.91226  1.000 11.34252 ?  35  ASN B ND2 1 
ATOM   2059 N  N   . GLY B 1 36  ? 19.83207  0.35476   14.18441  1.000 15.75300 ?  36  GLY B N   1 
ATOM   2060 C  CA  . GLY B 1 36  ? 20.65493  -0.24700  13.16219  1.000 12.91758 ?  36  GLY B CA  1 
ATOM   2061 C  C   . GLY B 1 36  ? 19.94608  -1.21014  12.23280  1.000 19.17020 ?  36  GLY B C   1 
ATOM   2062 O  O   . GLY B 1 36  ? 20.52556  -1.58404  11.20595  1.000 18.00163 ?  36  GLY B O   1 
ATOM   2063 N  N   . THR B 1 37  ? 18.71009  -1.62114  12.53985  1.000 15.82983 ?  37  THR B N   1 
ATOM   2064 C  CA  . THR B 1 37  ? 18.03760  -2.58767  11.68345  1.000 15.24226 ?  37  THR B CA  1 
ATOM   2065 C  C   . THR B 1 37  ? 17.29537  -1.94114  10.53155  1.000 18.61230 ?  37  THR B C   1 
ATOM   2066 O  O   . THR B 1 37  ? 16.79047  -2.66378  9.66268   1.000 16.50607 ?  37  THR B O   1 
ATOM   2067 C  CB  . THR B 1 37  ? 17.04279  -3.42554  12.47975  1.000 12.37037 ?  37  THR B CB  1 
ATOM   2068 O  OG1 . THR B 1 37  ? 15.96632  -2.58711  12.92154  1.000 11.15260 ?  37  THR B OG1 1 
ATOM   2069 C  CG2 . THR B 1 37  ? 17.72946  -4.08179  13.66931  1.000 12.71599 ?  37  THR B CG2 1 
ATOM   2070 N  N   . ARG B 1 38  ? 17.21929  -0.61255  10.50289  1.000 11.87171 ?  38  ARG B N   1 
ATOM   2071 C  CA  . ARG B 1 38  ? 16.35263  0.09861   9.57995   1.000 14.07057 ?  38  ARG B CA  1 
ATOM   2072 C  C   . ARG B 1 38  ? 17.17332  0.99803   8.67065   1.000 15.57636 ?  38  ARG B C   1 
ATOM   2073 O  O   . ARG B 1 38  ? 18.18694  1.55949   9.09149   1.000 16.24864 ?  38  ARG B O   1 
ATOM   2074 C  CB  . ARG B 1 38  ? 15.32101  0.92622   10.33061  1.000 12.29406 ?  38  ARG B CB  1 
ATOM   2075 C  CG  . ARG B 1 38  ? 14.28457  1.55065   9.42169   1.000 12.53462 ?  38  ARG B CG  1 
ATOM   2076 C  CD  . ARG B 1 38  ? 13.18109  2.19175   10.21325  1.000 15.88508 ?  38  ARG B CD  1 
ATOM   2077 N  NE  . ARG B 1 38  ? 12.49911  1.23726   11.07499  1.000 15.97586 ?  38  ARG B NE  1 
ATOM   2078 C  CZ  . ARG B 1 38  ? 11.39157  1.51575   11.74041  1.000 17.32969 ?  38  ARG B CZ  1 
ATOM   2079 N  NH1 . ARG B 1 38  ? 10.81668  2.70769   11.64278  1.000 14.54802 ?  38  ARG B NH1 1 
ATOM   2080 N  NH2 . ARG B 1 38  ? 10.84506  0.57683   12.51396  1.000 12.39030 ?  38  ARG B NH2 1 
ATOM   2081 N  N   . PHE B 1 39  ? 16.72247  1.12118   7.42164   1.000 12.34177 ?  39  PHE B N   1 
ATOM   2082 C  CA  . PHE B 1 39  ? 17.35785  1.92127   6.38250   1.000 12.50022 ?  39  PHE B CA  1 
ATOM   2083 C  C   . PHE B 1 39  ? 16.26816  2.71905   5.67006   1.000 18.14864 ?  39  PHE B C   1 
ATOM   2084 O  O   . PHE B 1 39  ? 15.17055  2.20450   5.44220   1.000 16.27982 ?  39  PHE B O   1 
ATOM   2085 C  CB  . PHE B 1 39  ? 18.13008  1.00905   5.41983   1.000 17.59150 ?  39  PHE B CB  1 
ATOM   2086 C  CG  . PHE B 1 39  ? 19.15793  0.14625   6.11295   1.000 18.92065 ?  39  PHE B CG  1 
ATOM   2087 C  CD1 . PHE B 1 39  ? 18.77881  -1.02019  6.76895   1.000 17.81269 ?  39  PHE B CD1 1 
ATOM   2088 C  CD2 . PHE B 1 39  ? 20.49376  0.51607   6.13100   1.000 20.77459 ?  39  PHE B CD2 1 
ATOM   2089 C  CE1 . PHE B 1 39  ? 19.71689  -1.79917  7.42487   1.000 21.91587 ?  39  PHE B CE1 1 
ATOM   2090 C  CE2 . PHE B 1 39  ? 21.43933  -0.25658  6.78060   1.000 18.85326 ?  39  PHE B CE2 1 
ATOM   2091 C  CZ  . PHE B 1 39  ? 21.05687  -1.40928  7.43259   1.000 21.92125 ?  39  PHE B CZ  1 
ATOM   2092 N  N   . LYS B 1 40  ? 16.54252  3.98196   5.34028   1.000 14.62016 ?  40  LYS B N   1 
ATOM   2093 C  CA  . LYS B 1 40  ? 15.43245  4.89230   5.08001   1.000 16.69473 ?  40  LYS B CA  1 
ATOM   2094 C  C   . LYS B 1 40  ? 15.78618  6.02093   4.11690   1.000 10.95003 ?  40  LYS B C   1 
ATOM   2095 O  O   . LYS B 1 40  ? 16.88830  6.56287   4.16088   1.000 15.17277 ?  40  LYS B O   1 
ATOM   2096 C  CB  . LYS B 1 40  ? 14.94918  5.51405   6.38920   1.000 14.82684 ?  40  LYS B CB  1 
ATOM   2097 C  CG  . LYS B 1 40  ? 13.76602  6.43205   6.20585   1.000 19.71325 ?  40  LYS B CG  1 
ATOM   2098 C  CD  . LYS B 1 40  ? 13.37750  7.02467   7.50588   1.000 21.65326 ?  40  LYS B CD  1 
ATOM   2099 C  CE  . LYS B 1 40  ? 11.95627  7.46332   7.45617   1.000 20.98061 ?  40  LYS B CE  1 
ATOM   2100 N  NZ  . LYS B 1 40  ? 11.06300  6.36112   7.82790   1.000 21.41189 ?  40  LYS B NZ  1 
ATOM   2101 N  N   . ARG B 1 41  ? 14.82029  6.38352   3.27223   1.000 14.73416 ?  41  ARG B N   1 
ATOM   2102 C  CA  . ARG B 1 41  ? 14.81110  7.64245   2.54154   1.000 12.44973 ?  41  ARG B CA  1 
ATOM   2103 C  C   . ARG B 1 41  ? 13.41676  8.24155   2.66713   1.000 14.31131 ?  41  ARG B C   1 
ATOM   2104 O  O   . ARG B 1 41  ? 12.43847  7.52596   2.89078   1.000 13.81471 ?  41  ARG B O   1 
ATOM   2105 C  CB  . ARG B 1 41  ? 15.19383  7.46005   1.06552   1.000 14.98597 ?  41  ARG B CB  1 
ATOM   2106 C  CG  . ARG B 1 41  ? 16.66081  7.12422   0.85874   1.000 11.23311 ?  41  ARG B CG  1 
ATOM   2107 C  CD  . ARG B 1 41  ? 16.97810  7.03074   -0.63179  1.000 16.01829 ?  41  ARG B CD  1 
ATOM   2108 N  NE  . ARG B 1 41  ? 18.38258  6.70666   -0.86067  1.000 19.44570 ?  41  ARG B NE  1 
ATOM   2109 C  CZ  . ARG B 1 41  ? 19.33177  7.61338   -1.04964  1.000 24.53801 ?  41  ARG B CZ  1 
ATOM   2110 N  NH1 . ARG B 1 41  ? 19.05284  8.91127   -1.07118  1.000 18.95211 ?  41  ARG B NH1 1 
ATOM   2111 N  NH2 . ARG B 1 41  ? 20.59264  7.21026   -1.20238  1.000 20.42136 ?  41  ARG B NH2 1 
ATOM   2112 N  N   . PHE B 1 42  ? 13.33632  9.56395   2.53516   1.000 11.48343 ?  42  PHE B N   1 
ATOM   2113 C  CA  . PHE B 1 42  ? 12.14774  10.31736  2.91606   1.000 12.15592 ?  42  PHE B CA  1 
ATOM   2114 C  C   . PHE B 1 42  ? 11.95338  11.51172  1.98866   1.000 19.95901 ?  42  PHE B C   1 
ATOM   2115 O  O   . PHE B 1 42  ? 12.87113  12.31962  1.81252   1.000 18.34875 ?  42  PHE B O   1 
ATOM   2116 C  CB  . PHE B 1 42  ? 12.28526  10.77861  4.37304   1.000 12.48602 ?  42  PHE B CB  1 
ATOM   2117 C  CG  . PHE B 1 42  ? 11.21038  11.72527  4.83018   1.000 16.74794 ?  42  PHE B CG  1 
ATOM   2118 C  CD1 . PHE B 1 42  ? 9.93077   11.26147  5.12058   1.000 12.47448 ?  42  PHE B CD1 1 
ATOM   2119 C  CD2 . PHE B 1 42  ? 11.49599  13.07156  5.02221   1.000 17.32658 ?  42  PHE B CD2 1 
ATOM   2120 C  CE1 . PHE B 1 42  ? 8.94424   12.13176  5.57381   1.000 13.74780 ?  42  PHE B CE1 1 
ATOM   2121 C  CE2 . PHE B 1 42  ? 10.51037  13.96395  5.47090   1.000 16.93368 ?  42  PHE B CE2 1 
ATOM   2122 C  CZ  . PHE B 1 42  ? 9.23591   13.49227  5.74481   1.000 14.95715 ?  42  PHE B CZ  1 
ATOM   2123 N  N   . SER B 1 43  ? 10.76254  11.62154  1.39769   1.000 14.60396 ?  43  SER B N   1 
ATOM   2124 C  CA  A SER B 1 43  ? 10.41076  12.77573  0.58846   0.883 12.89077 ?  43  SER B CA  1 
ATOM   2125 C  CA  B SER B 1 43  ? 10.40407  12.76953  0.57859   0.117 13.23776 ?  43  SER B CA  1 
ATOM   2126 C  C   . SER B 1 43  ? 8.97279   13.17705  0.89406   1.000 14.73926 ?  43  SER B C   1 
ATOM   2127 O  O   . SER B 1 43  ? 8.18761   12.39989  1.44553   1.000 14.58829 ?  43  SER B O   1 
ATOM   2128 C  CB  A SER B 1 43  ? 10.60677  12.49311  -0.91710  0.883 17.00856 ?  43  SER B CB  1 
ATOM   2129 C  CB  B SER B 1 43  ? 10.55636  12.47474  -0.92185  0.117 16.96859 ?  43  SER B CB  1 
ATOM   2130 O  OG  A SER B 1 43  ? 11.99225  12.37219  -1.23654  0.883 16.21524 ?  43  SER B OG  1 
ATOM   2131 O  OG  B SER B 1 43  ? 9.73885   11.39091  -1.32086  0.117 15.36570 ?  43  SER B OG  1 
ATOM   2132 N  N   . GLN B 1 44  ? 8.63255   14.41209  0.54643   1.000 12.50319 ?  44  GLN B N   1 
ATOM   2133 C  CA  . GLN B 1 44  ? 7.29429   14.91880  0.79090   1.000 15.20171 ?  44  GLN B CA  1 
ATOM   2134 C  C   . GLN B 1 44  ? 6.74290   15.49630  -0.49387  1.000 14.58912 ?  44  GLN B C   1 
ATOM   2135 O  O   . GLN B 1 44  ? 7.49150   16.04604  -1.30354  1.000 15.51374 ?  44  GLN B O   1 
ATOM   2136 C  CB  . GLN B 1 44  ? 7.28375   15.96192  1.91127   1.000 13.44278 ?  44  GLN B CB  1 
ATOM   2137 C  CG  . GLN B 1 44  ? 7.54606   15.32734  3.26836   1.000 15.68253 ?  44  GLN B CG  1 
ATOM   2138 C  CD  . GLN B 1 44  ? 7.87984   16.33252  4.34501   1.000 16.09853 ?  44  GLN B CD  1 
ATOM   2139 O  OE1 . GLN B 1 44  ? 8.94035   16.96804  4.32280   1.000 15.14236 ?  44  GLN B OE1 1 
ATOM   2140 N  NE2 . GLN B 1 44  ? 6.98596   16.46705  5.31131   1.000 14.23644 ?  44  GLN B NE2 1 
ATOM   2141 N  N   . TYR B 1 45  ? 5.43652   15.33728  -0.69030  1.000 12.27029 ?  45  TYR B N   1 
ATOM   2142 C  CA  . TYR B 1 45  ? 4.78263   15.80052  -1.90259  1.000 19.22577 ?  45  TYR B CA  1 
ATOM   2143 C  C   . TYR B 1 45  ? 3.53018   16.57652  -1.55044  1.000 18.64732 ?  45  TYR B C   1 
ATOM   2144 O  O   . TYR B 1 45  ? 2.89612   16.33871  -0.51873  1.000 18.55967 ?  45  TYR B O   1 
ATOM   2145 C  CB  . TYR B 1 45  ? 4.35459   14.65249  -2.85868  1.000 16.37618 ?  45  TYR B CB  1 
ATOM   2146 C  CG  . TYR B 1 45  ? 5.47965   13.84558  -3.46020  1.000 20.01331 ?  45  TYR B CG  1 
ATOM   2147 C  CD1 . TYR B 1 45  ? 6.10109   12.83525  -2.73829  1.000 17.10303 ?  45  TYR B CD1 1 
ATOM   2148 C  CD2 . TYR B 1 45  ? 5.90459   14.07833  -4.76467  1.000 21.05258 ?  45  TYR B CD2 1 
ATOM   2149 C  CE1 . TYR B 1 45  ? 7.13128   12.09152  -3.29694  1.000 20.30280 ?  45  TYR B CE1 1 
ATOM   2150 C  CE2 . TYR B 1 45  ? 6.92312   13.33674  -5.32783  1.000 25.24687 ?  45  TYR B CE2 1 
ATOM   2151 C  CZ  . TYR B 1 45  ? 7.53612   12.34900  -4.58695  1.000 25.50539 ?  45  TYR B CZ  1 
ATOM   2152 O  OH  . TYR B 1 45  ? 8.55127   11.61710  -5.14301  1.000 24.93726 ?  45  TYR B OH  1 
ATOM   2153 N  N   . LYS B 1 46  ? 3.18583   17.49831  -2.44329  1.000 15.35467 ?  46  LYS B N   1 
ATOM   2154 C  CA  . LYS B 1 46  ? 1.87859   18.12755  -2.49148  1.000 17.21690 ?  46  LYS B CA  1 
ATOM   2155 C  C   . LYS B 1 46  ? 1.02621   17.39466  -3.51956  1.000 15.42808 ?  46  LYS B C   1 
ATOM   2156 O  O   . LYS B 1 46  ? 1.48021   17.14562  -4.64135  1.000 18.36435 ?  46  LYS B O   1 
ATOM   2157 C  CB  . LYS B 1 46  ? 2.00679   19.60944  -2.86003  1.000 19.59043 ?  46  LYS B CB  1 
ATOM   2158 C  CG  . LYS B 1 46  ? 0.67571   20.29060  -3.10851  1.000 16.13993 ?  46  LYS B CG  1 
ATOM   2159 C  CD  . LYS B 1 46  ? 0.88314   21.75178  -3.50656  1.000 23.97048 ?  46  LYS B CD  1 
ATOM   2160 C  CE  . LYS B 1 46  ? -0.37975  22.55895  -3.27030  1.000 18.19208 ?  46  LYS B CE  1 
ATOM   2161 N  NZ  . LYS B 1 46  ? -0.31362  23.88390  -3.95123  1.000 21.19994 ?  46  LYS B NZ  1 
ATOM   2162 N  N   . LEU B 1 47  ? -0.18586  17.01961  -3.11897  1.000 18.81297 ?  47  LEU B N   1 
ATOM   2163 C  CA  . LEU B 1 47  ? -1.14916  16.35553  -3.98303  1.000 20.80240 ?  47  LEU B CA  1 
ATOM   2164 C  C   . LEU B 1 47  ? -2.25406  17.34180  -4.30425  1.000 23.89469 ?  47  LEU B C   1 
ATOM   2165 O  O   . LEU B 1 47  ? -2.90748  17.85958  -3.39260  1.000 22.47810 ?  47  LEU B O   1 
ATOM   2166 C  CB  . LEU B 1 47  ? -1.78329  15.13797  -3.32586  1.000 23.60814 ?  47  LEU B CB  1 
ATOM   2167 C  CG  . LEU B 1 47  ? -0.92805  14.01335  -2.82367  1.000 23.63980 ?  47  LEU B CG  1 
ATOM   2168 C  CD1 . LEU B 1 47  ? -1.83126  12.87139  -2.38647  1.000 18.15975 ?  47  LEU B CD1 1 
ATOM   2169 C  CD2 . LEU B 1 47  ? -0.05121  13.62981  -3.95293  1.000 28.34612 ?  47  LEU B CD2 1 
ATOM   2170 N  N   . THR B 1 48  ? -2.48692  17.55919  -5.59112  1.000 30.49467 ?  48  THR B N   1 
ATOM   2171 C  CA  . THR B 1 48  ? -3.50253  18.46009  -6.08387  1.000 34.38547 ?  48  THR B CA  1 
ATOM   2172 C  C   . THR B 1 48  ? -4.41310  17.73463  -7.06379  1.000 35.66173 ?  48  THR B C   1 
ATOM   2173 O  O   . THR B 1 48  ? -3.92698  16.98058  -7.91574  1.000 38.71618 ?  48  THR B O   1 
ATOM   2174 C  CB  . THR B 1 48  ? -2.84045  19.64619  -6.77080  1.000 34.93423 ?  48  THR B CB  1 
ATOM   2175 O  OG1 . THR B 1 48  ? -2.07638  19.16395  -7.88077  1.000 29.83400 ?  48  THR B OG1 1 
ATOM   2176 C  CG2 . THR B 1 48  ? -1.89404  20.32574  -5.80127  1.000 23.67283 ?  48  THR B CG2 1 
ATOM   2177 N  N   . PRO B 1 49  ? -5.73008  17.90156  -6.95109  1.000 39.81150 ?  49  PRO B N   1 
ATOM   2178 C  CA  . PRO B 1 49  ? -6.62361  17.34109  -7.97023  1.000 38.12440 ?  49  PRO B CA  1 
ATOM   2179 C  C   . PRO B 1 49  ? -6.38671  18.02902  -9.30656  1.000 39.84021 ?  49  PRO B C   1 
ATOM   2180 O  O   . PRO B 1 49  ? -6.27728  19.25500  -9.37761  1.000 36.89613 ?  49  PRO B O   1 
ATOM   2181 C  CB  . PRO B 1 49  ? -8.02324  17.62816  -7.41997  1.000 36.65040 ?  49  PRO B CB  1 
ATOM   2182 C  CG  . PRO B 1 49  ? -7.83372  18.76136  -6.47315  1.000 38.96897 ?  49  PRO B CG  1 
ATOM   2183 C  CD  . PRO B 1 49  ? -6.47631  18.56180  -5.86411  1.000 31.70070 ?  49  PRO B CD  1 
ATOM   2184 N  N   . ALA B 1 50  ? -6.30051  17.22607  -10.36330 1.000 52.71935 ?  50  ALA B N   1 
ATOM   2185 C  CA  . ALA B 1 50  ? -5.90668  17.68734  -11.69469 1.000 56.37763 ?  50  ALA B CA  1 
ATOM   2186 C  C   . ALA B 1 50  ? -6.91667  17.18808  -12.73044 1.000 65.56365 ?  50  ALA B C   1 
ATOM   2187 O  O   . ALA B 1 50  ? -6.75915  16.09817  -13.28472 1.000 50.46815 ?  50  ALA B O   1 
ATOM   2188 C  CB  . ALA B 1 50  ? -4.50250  17.21809  -12.02841 1.000 46.42857 ?  50  ALA B CB  1 
ATOM   2189 N  N   . GLU B 1 51  ? -7.95558  17.98078  -12.97319 1.000 66.46683 ?  51  GLU B N   1 
ATOM   2190 C  CA  . GLU B 1 51  ? -8.85829  17.81264  -14.12971 1.000 61.97831 ?  51  GLU B CA  1 
ATOM   2191 C  C   . GLU B 1 51  ? -9.59163  16.47460  -14.00607 1.000 66.09087 ?  51  GLU B C   1 
ATOM   2192 O  O   . GLU B 1 51  ? -10.06075 16.12500  -12.91482 1.000 67.82292 ?  51  GLU B O   1 
ATOM   2193 C  CB  . GLU B 1 51  ? -8.06054  17.98618  -15.41464 1.000 62.88333 ?  51  GLU B CB  1 
ATOM   2194 C  CG  . GLU B 1 51  ? -7.67187  19.43520  -15.73121 1.000 64.86342 ?  51  GLU B CG  1 
ATOM   2195 C  CD  . GLU B 1 51  ? -8.79014  20.22076  -16.40148 1.000 68.97698 ?  51  GLU B CD  1 
ATOM   2196 O  OE1 . GLU B 1 51  ? -9.97523  19.86613  -16.20530 1.000 65.80091 ?  51  GLU B OE1 1 
ATOM   2197 O  OE2 . GLU B 1 51  ? -8.47941  21.18673  -17.13655 1.000 65.12567 ?  51  GLU B OE2 1 
ATOM   2198 N  N   . ASP B 1 52  ? -9.71909  15.72045  -15.09450 1.000 65.41959 ?  52  ASP B N   1 
ATOM   2199 C  CA  . ASP B 1 52  ? -10.59093 14.55490  -15.13821 1.000 66.67898 ?  52  ASP B CA  1 
ATOM   2200 C  C   . ASP B 1 52  ? -10.03812 13.40601  -14.30355 1.000 61.42838 ?  52  ASP B C   1 
ATOM   2201 O  O   . ASP B 1 52  ? -9.37280  12.50612  -14.83403 1.000 63.74065 ?  52  ASP B O   1 
ATOM   2202 C  CB  . ASP B 1 52  ? -10.81060 14.11073  -16.58766 1.000 65.59332 ?  52  ASP B CB  1 
ATOM   2203 C  CG  . ASP B 1 52  ? -12.25759 13.74396  -16.86742 1.000 64.87430 ?  52  ASP B CG  1 
ATOM   2204 O  OD1 . ASP B 1 52  ? -12.74772 12.75616  -16.28588 1.000 59.21900 ?  52  ASP B OD1 1 
ATOM   2205 O  OD2 . ASP B 1 52  ? -12.90723 14.46562  -17.66017 1.000 75.13134 ?  52  ASP B OD2 1 
ATOM   2206 N  N   . ASP B 1 53  ? -10.31882 13.44608  -12.99437 1.000 58.70316 ?  53  ASP B N   1 
ATOM   2207 C  CA  . ASP B 1 53  ? -9.97556  12.37436  -12.05140 1.000 65.12086 ?  53  ASP B CA  1 
ATOM   2208 C  C   . ASP B 1 53  ? -8.48560  12.03870  -12.05570 1.000 60.87108 ?  53  ASP B C   1 
ATOM   2209 O  O   . ASP B 1 53  ? -8.08657  10.88611  -11.88485 1.000 55.92299 ?  53  ASP B O   1 
ATOM   2210 C  CB  . ASP B 1 53  ? -10.80950 11.11845  -12.32100 1.000 65.43997 ?  53  ASP B CB  1 
ATOM   2211 C  CG  . ASP B 1 53  ? -11.94815 10.95427  -11.33172 1.000 65.22489 ?  53  ASP B CG  1 
ATOM   2212 O  OD1 . ASP B 1 53  ? -12.43212 11.97922  -10.79050 1.000 57.50873 ?  53  ASP B OD1 1 
ATOM   2213 O  OD2 . ASP B 1 53  ? -12.35545 9.79720   -11.08555 1.000 76.67368 ?  53  ASP B OD2 1 
ATOM   2214 N  N   . THR B 1 54  ? -7.64942  13.04815  -12.23884 1.000 54.82915 ?  54  THR B N   1 
ATOM   2215 C  CA  . THR B 1 54  ? -6.21557  12.85748  -12.10355 1.000 52.70356 ?  54  THR B CA  1 
ATOM   2216 C  C   . THR B 1 54  ? -5.72139  13.65449  -10.90906 1.000 43.61105 ?  54  THR B C   1 
ATOM   2217 O  O   . THR B 1 54  ? -6.26232  14.71461  -10.58177 1.000 51.13737 ?  54  THR B O   1 
ATOM   2218 C  CB  . THR B 1 54  ? -5.44018  13.29096  -13.35907 1.000 49.70371 ?  54  THR B CB  1 
ATOM   2219 O  OG1 . THR B 1 54  ? -6.19978  12.96803  -14.52929 1.000 68.32081 ?  54  THR B OG1 1 
ATOM   2220 C  CG2 . THR B 1 54  ? -4.10076  12.57240  -13.42605 1.000 50.62723 ?  54  THR B CG2 1 
ATOM   2221 N  N   . TRP B 1 55  ? -4.68718  13.13420  -10.26218 1.000 41.46033 ?  55  TRP B N   1 
ATOM   2222 C  CA  . TRP B 1 55  ? -3.99926  13.84234  -9.19901  1.000 38.19419 ?  55  TRP B CA  1 
ATOM   2223 C  C   . TRP B 1 55  ? -2.58188  14.12346  -9.64719  1.000 34.04033 ?  55  TRP B C   1 
ATOM   2224 O  O   . TRP B 1 55  ? -1.92139  13.25626  -10.22133 1.000 31.92997 ?  55  TRP B O   1 
ATOM   2225 C  CB  . TRP B 1 55  ? -3.97343  13.04314  -7.91198  1.000 35.00713 ?  55  TRP B CB  1 
ATOM   2226 C  CG  . TRP B 1 55  ? -5.27935  12.91366  -7.27329  1.000 32.34304 ?  55  TRP B CG  1 
ATOM   2227 C  CD1 . TRP B 1 55  ? -6.26767  12.04281  -7.61196  1.000 33.96017 ?  55  TRP B CD1 1 
ATOM   2228 C  CD2 . TRP B 1 55  ? -5.76081  13.65794  -6.15740  1.000 28.35557 ?  55  TRP B CD2 1 
ATOM   2229 N  NE1 . TRP B 1 55  ? -7.34072  12.19492  -6.77290  1.000 35.23642 ?  55  TRP B NE1 1 
ATOM   2230 C  CE2 . TRP B 1 55  ? -7.05601  13.18027  -5.86814  1.000 26.03394 ?  55  TRP B CE2 1 
ATOM   2231 C  CE3 . TRP B 1 55  ? -5.22037  14.66721  -5.36117  1.000 27.77863 ?  55  TRP B CE3 1 
ATOM   2232 C  CZ2 . TRP B 1 55  ? -7.82423  13.68754  -4.82972  1.000 27.63154 ?  55  TRP B CZ2 1 
ATOM   2233 C  CZ3 . TRP B 1 55  ? -5.98613  15.17273  -4.33077  1.000 32.25907 ?  55  TRP B CZ3 1 
ATOM   2234 C  CH2 . TRP B 1 55  ? -7.27568  14.68182  -4.07310  1.000 30.85380 ?  55  TRP B CH2 1 
ATOM   2235 N  N   . SER B 1 56  ? -2.12001  15.33142  -9.38389  1.000 31.35053 ?  56  SER B N   1 
ATOM   2236 C  CA  . SER B 1 56  ? -0.75776  15.69925  -9.71714  1.000 35.51889 ?  56  SER B CA  1 
ATOM   2237 C  C   . SER B 1 56  ? 0.11449   15.69026  -8.46680  1.000 32.71698 ?  56  SER B C   1 
ATOM   2238 O  O   . SER B 1 56  ? -0.33394  16.05458  -7.37793  1.000 29.21912 ?  56  SER B O   1 
ATOM   2239 C  CB  . SER B 1 56  ? -0.71839  17.06768  -10.38330 1.000 33.28429 ?  56  SER B CB  1 
ATOM   2240 O  OG  . SER B 1 56  ? 0.57883   17.30867  -10.90120 1.000 46.88113 ?  56  SER B OG  1 
ATOM   2241 N  N   . PHE B 1 57  ? 1.36011   15.26753  -8.63409  1.000 27.33946 ?  57  PHE B N   1 
ATOM   2242 C  CA  . PHE B 1 57  ? 2.32348   15.16711  -7.54963  1.000 29.05283 ?  57  PHE B CA  1 
ATOM   2243 C  C   . PHE B 1 57  ? 3.42152   16.19585  -7.75912  1.000 27.37438 ?  57  PHE B C   1 
ATOM   2244 O  O   . PHE B 1 57  ? 3.99096   16.27764  -8.85134  1.000 35.53226 ?  57  PHE B O   1 
ATOM   2245 C  CB  . PHE B 1 57  ? 2.95772   13.77866  -7.50262  1.000 21.61750 ?  57  PHE B CB  1 
ATOM   2246 C  CG  . PHE B 1 57  ? 2.00979   12.67666  -7.16148  1.000 23.97892 ?  57  PHE B CG  1 
ATOM   2247 C  CD1 . PHE B 1 57  ? 1.06343   12.25132  -8.07682  1.000 27.10381 ?  57  PHE B CD1 1 
ATOM   2248 C  CD2 . PHE B 1 57  ? 2.10310   12.02405  -5.94472  1.000 23.44143 ?  57  PHE B CD2 1 
ATOM   2249 C  CE1 . PHE B 1 57  ? 0.20627   11.22053  -7.77320  1.000 30.75195 ?  57  PHE B CE1 1 
ATOM   2250 C  CE2 . PHE B 1 57  ? 1.25321   10.97913  -5.63515  1.000 28.19956 ?  57  PHE B CE2 1 
ATOM   2251 C  CZ  . PHE B 1 57  ? 0.29740   10.58417  -6.54788  1.000 29.28318 ?  57  PHE B CZ  1 
ATOM   2252 N  N   . LYS B 1 58  ? 3.74204   16.95126  -6.71036  1.000 25.97610 ?  58  LYS B N   1 
ATOM   2253 C  CA  . LYS B 1 58  ? 4.84975   17.89733  -6.74492  1.000 25.68460 ?  58  LYS B CA  1 
ATOM   2254 C  C   . LYS B 1 58  ? 5.74060   17.65478  -5.54002  1.000 24.58011 ?  58  LYS B C   1 
ATOM   2255 O  O   . LYS B 1 58  ? 5.28930   17.77234  -4.39506  1.000 23.10555 ?  58  LYS B O   1 
ATOM   2256 C  CB  . LYS B 1 58  ? 4.36418   19.34455  -6.74757  1.000 24.42120 ?  58  LYS B CB  1 
ATOM   2257 C  CG  . LYS B 1 58  ? 5.47204   20.31953  -7.08374  1.000 33.53989 ?  58  LYS B CG  1 
ATOM   2258 C  CD  . LYS B 1 58  ? 5.26054   21.69096  -6.47171  1.000 32.94629 ?  58  LYS B CD  1 
ATOM   2259 C  CE  . LYS B 1 58  ? 6.59159   22.45448  -6.39936  1.000 47.59694 ?  58  LYS B CE  1 
ATOM   2260 N  NZ  . LYS B 1 58  ? 7.18961   22.74457  -7.74782  1.000 48.66215 ?  58  LYS B NZ  1 
ATOM   2261 N  N   . ARG B 1 59  ? 7.00004   17.32883  -5.80474  1.000 24.68488 ?  59  ARG B N   1 
ATOM   2262 C  CA  . ARG B 1 59  ? 7.96696   17.07443  -4.74945  1.000 25.09191 ?  59  ARG B CA  1 
ATOM   2263 C  C   . ARG B 1 59  ? 8.31277   18.38942  -4.06641  1.000 25.75293 ?  59  ARG B C   1 
ATOM   2264 O  O   . ARG B 1 59  ? 8.65489   19.36714  -4.73256  1.000 25.26199 ?  59  ARG B O   1 
ATOM   2265 C  CB  . ARG B 1 59  ? 9.21166   16.42086  -5.34983  1.000 24.33305 ?  59  ARG B CB  1 
ATOM   2266 C  CG  . ARG B 1 59  ? 10.13723  15.73068  -4.38389  1.000 30.42265 ?  59  ARG B CG  1 
ATOM   2267 C  CD  . ARG B 1 59  ? 11.40803  15.26057  -5.10592  1.000 34.61908 ?  59  ARG B CD  1 
ATOM   2268 N  NE  . ARG B 1 59  ? 11.24990  13.95179  -5.73312  1.000 40.98356 ?  59  ARG B NE  1 
ATOM   2269 C  CZ  . ARG B 1 59  ? 11.80031  12.83236  -5.27950  1.000 34.91725 ?  59  ARG B CZ  1 
ATOM   2270 N  NH1 . ARG B 1 59  ? 12.54597  12.82050  -4.18422  1.000 31.34502 ?  59  ARG B NH1 1 
ATOM   2271 N  NH2 . ARG B 1 59  ? 11.60661  11.69726  -5.94550  1.000 33.10520 ?  59  ARG B NH2 1 
ATOM   2272 N  N   . LEU B 1 60  ? 8.17939   18.42519  -2.73696  1.000 17.98636 ?  60  LEU B N   1 
ATOM   2273 C  CA  . LEU B 1 60  ? 8.41716   19.63788  -1.97664  1.000 18.63972 ?  60  LEU B CA  1 
ATOM   2274 C  C   . LEU B 1 60  ? 9.89923   19.76277  -1.65369  1.000 20.74614 ?  60  LEU B C   1 
ATOM   2275 O  O   . LEU B 1 60  ? 10.61255  18.75638  -1.60742  1.000 15.76089 ?  60  LEU B O   1 
ATOM   2276 C  CB  . LEU B 1 60  ? 7.61011   19.62001  -0.68528  1.000 20.72049 ?  60  LEU B CB  1 
ATOM   2277 C  CG  . LEU B 1 60  ? 6.08998   19.64521  -0.88271  1.000 18.59253 ?  60  LEU B CG  1 
ATOM   2278 C  CD1 . LEU B 1 60  ? 5.35471   19.37426  0.41824   1.000 17.55035 ?  60  LEU B CD1 1 
ATOM   2279 C  CD2 . LEU B 1 60  ? 5.68962   20.98826  -1.45983  1.000 19.49646 ?  60  LEU B CD2 1 
ATOM   2280 N  N   . PRO B 1 61  ? 10.39220  20.98353  -1.45070  1.000 18.15879 ?  61  PRO B N   1 
ATOM   2281 C  CA  . PRO B 1 61  ? 11.78476  21.14345  -1.01977  1.000 16.24760 ?  61  PRO B CA  1 
ATOM   2282 C  C   . PRO B 1 61  ? 12.07493  20.26175  0.18634   1.000 25.52288 ?  61  PRO B C   1 
ATOM   2283 O  O   . PRO B 1 61  ? 11.31305  20.23107  1.15638   1.000 20.79143 ?  61  PRO B O   1 
ATOM   2284 C  CB  . PRO B 1 61  ? 11.88214  22.63550  -0.67629  1.000 18.70671 ?  61  PRO B CB  1 
ATOM   2285 C  CG  . PRO B 1 61  ? 10.86329  23.27597  -1.58763  1.000 19.96320 ?  61  PRO B CG  1 
ATOM   2286 C  CD  . PRO B 1 61  ? 9.71804   22.28423  -1.64558  1.000 23.71848 ?  61  PRO B CD  1 
ATOM   2287 N  N   . HIS B 1 62  ? 13.17667  19.52207  0.09669   1.000 20.57371 ?  62  HIS B N   1 
ATOM   2288 C  CA  . HIS B 1 62  ? 13.53072  18.51927  1.09192   1.000 20.65246 ?  62  HIS B CA  1 
ATOM   2289 C  C   . HIS B 1 62  ? 13.67266  19.13430  2.47975   1.000 25.76299 ?  62  HIS B C   1 
ATOM   2290 O  O   . HIS B 1 62  ? 14.44397  20.07677  2.67153   1.000 24.16704 ?  62  HIS B O   1 
ATOM   2291 C  CB  . HIS B 1 62  ? 14.84314  17.87270  0.67577   1.000 19.88818 ?  62  HIS B CB  1 
ATOM   2292 C  CG  . HIS B 1 62  ? 15.21800  16.68541  1.49435   1.000 22.94028 ?  62  HIS B CG  1 
ATOM   2293 N  ND1 . HIS B 1 62  ? 14.45044  15.54084  1.53192   1.000 21.04253 ?  62  HIS B ND1 1 
ATOM   2294 C  CD2 . HIS B 1 62  ? 16.27842  16.45864  2.30349   1.000 24.76453 ?  62  HIS B CD2 1 
ATOM   2295 C  CE1 . HIS B 1 62  ? 15.02356  14.65900  2.32993   1.000 24.37786 ?  62  HIS B CE1 1 
ATOM   2296 N  NE2 . HIS B 1 62  ? 16.13690  15.18934  2.80773   1.000 23.21921 ?  62  HIS B NE2 1 
ATOM   2297 N  N   . ARG B 1 63  ? 12.94769  18.58755  3.45895   1.000 17.55532 ?  63  ARG B N   1 
ATOM   2298 C  CA  . ARG B 1 63  ? 13.06859  19.05172  4.83479   1.000 14.62806 ?  63  ARG B CA  1 
ATOM   2299 C  C   . ARG B 1 63  ? 13.24621  17.87698  5.78503   1.000 19.90396 ?  63  ARG B C   1 
ATOM   2300 O  O   . ARG B 1 63  ? 12.85916  16.74836  5.47907   1.000 18.29095 ?  63  ARG B O   1 
ATOM   2301 C  CB  . ARG B 1 63  ? 11.84507  19.84503  5.29128   1.000 18.30023 ?  63  ARG B CB  1 
ATOM   2302 C  CG  . ARG B 1 63  ? 11.72134  21.22130  4.67611   1.000 21.98508 ?  63  ARG B CG  1 
ATOM   2303 C  CD  . ARG B 1 63  ? 10.41038  21.83277  5.10543   1.000 23.62883 ?  63  ARG B CD  1 
ATOM   2304 N  NE  . ARG B 1 63  ? 10.39340  22.23862  6.50341   1.000 25.18997 ?  63  ARG B NE  1 
ATOM   2305 C  CZ  . ARG B 1 63  ? 10.66349  23.46853  6.91845   1.000 25.24464 ?  63  ARG B CZ  1 
ATOM   2306 N  NH1 . ARG B 1 63  ? 11.11103  24.39447  6.08504   1.000 22.93572 ?  63  ARG B NH1 1 
ATOM   2307 N  NH2 . ARG B 1 63  ? 10.46397  23.78166  8.19608   1.000 21.93529 ?  63  ARG B NH2 1 
ATOM   2308 N  N   . ASP B 1 64  ? 13.80898  18.16427  6.95836   1.000 18.76460 ?  64  ASP B N   1 
ATOM   2309 C  CA  . ASP B 1 64  ? 13.83837  17.17194  8.02704   1.000 15.11702 ?  64  ASP B CA  1 
ATOM   2310 C  C   . ASP B 1 64  ? 12.43564  16.65058  8.31157   1.000 15.28943 ?  64  ASP B C   1 
ATOM   2311 O  O   . ASP B 1 64  ? 11.45442  17.39527  8.26747   1.000 19.96689 ?  64  ASP B O   1 
ATOM   2312 C  CB  . ASP B 1 64  ? 14.41500  17.75673  9.31422   1.000 14.42244 ?  64  ASP B CB  1 
ATOM   2313 C  CG  . ASP B 1 64  ? 15.85161  18.21419  9.17022   1.000 20.42213 ?  64  ASP B CG  1 
ATOM   2314 O  OD1 . ASP B 1 64  ? 16.49612  17.89782  8.14136   1.000 21.27940 ?  64  ASP B OD1 1 
ATOM   2315 O  OD2 . ASP B 1 64  ? 16.31676  18.91010  10.10116  1.000 21.02428 -1 64  ASP B OD2 1 
ATOM   2316 N  N   . TYR B 1 65  ? 12.35879  15.36230  8.62173   1.000 11.30737 ?  65  TYR B N   1 
ATOM   2317 C  CA  . TYR B 1 65  ? 11.12745  14.74014  9.08632   1.000 15.95795 ?  65  TYR B CA  1 
ATOM   2318 C  C   . TYR B 1 65  ? 10.91304  15.06786  10.55656  1.000 13.18141 ?  65  TYR B C   1 
ATOM   2319 O  O   . TYR B 1 65  ? 11.83949  14.94790  11.35763  1.000 11.59850 ?  65  TYR B O   1 
ATOM   2320 C  CB  . TYR B 1 65  ? 11.21896  13.22837  8.90372   1.000 9.39789  ?  65  TYR B CB  1 
ATOM   2321 C  CG  . TYR B 1 65  ? 10.06469  12.44471  9.48716   1.000 11.63457 ?  65  TYR B CG  1 
ATOM   2322 C  CD1 . TYR B 1 65  ? 8.75570   12.77568  9.18227   1.000 11.92677 ?  65  TYR B CD1 1 
ATOM   2323 C  CD2 . TYR B 1 65  ? 10.28839  11.35298  10.31873  1.000 13.60808 ?  65  TYR B CD2 1 
ATOM   2324 C  CE1 . TYR B 1 65  ? 7.69511   12.05067  9.69731   1.000 16.00613 ?  65  TYR B CE1 1 
ATOM   2325 C  CE2 . TYR B 1 65  ? 9.23755   10.62039  10.84730  1.000 16.64218 ?  65  TYR B CE2 1 
ATOM   2326 C  CZ  . TYR B 1 65  ? 7.94394   10.97589  10.52792  1.000 13.67230 ?  65  TYR B CZ  1 
ATOM   2327 O  OH  . TYR B 1 65  ? 6.90217   10.25754  11.03640  1.000 16.84058 ?  65  TYR B OH  1 
ATOM   2328 N  N   . THR B 1 66  ? 9.70030   15.49656  10.90868  1.000 11.05365 ?  66  THR B N   1 
ATOM   2329 C  CA  . THR B 1 66  ? 9.32756   15.71585  12.30238  1.000 14.19515 ?  66  THR B CA  1 
ATOM   2330 C  C   . THR B 1 66  ? 7.94623   15.13297  12.53394  1.000 15.43492 ?  66  THR B C   1 
ATOM   2331 O  O   . THR B 1 66  ? 7.03621   15.34691  11.72631  1.000 14.18882 ?  66  THR B O   1 
ATOM   2332 C  CB  . THR B 1 66  ? 9.29346   17.19788  12.66624  1.000 15.45439 ?  66  THR B CB  1 
ATOM   2333 O  OG1 . THR B 1 66  ? 8.39114   17.86111  11.77078  1.000 14.02647 ?  66  THR B OG1 1 
ATOM   2334 C  CG2 . THR B 1 66  ? 10.69120  17.81360  12.56670  1.000 17.73393 ?  66  THR B CG2 1 
ATOM   2335 N  N   . THR B 1 67  ? 7.79239   14.39834  13.63239  1.000 13.94804 ?  67  THR B N   1 
ATOM   2336 C  CA  . THR B 1 67  ? 6.48404   13.92082  14.05510  1.000 13.27436 ?  67  THR B CA  1 
ATOM   2337 C  C   . THR B 1 67  ? 6.33138   14.20644  15.54394  1.000 15.14392 ?  67  THR B C   1 
ATOM   2338 O  O   . THR B 1 67  ? 7.24771   14.71043  16.19254  1.000 14.43412 ?  67  THR B O   1 
ATOM   2339 C  CB  . THR B 1 67  ? 6.28096   12.43039  13.73253  1.000 11.94387 ?  67  THR B CB  1 
ATOM   2340 O  OG1 . THR B 1 67  ? 5.00159   12.02869  14.21260  1.000 10.34975 ?  67  THR B OG1 1 
ATOM   2341 C  CG2 . THR B 1 67  ? 7.33426   11.56504  14.39324  1.000 11.55580 ?  67  THR B CG2 1 
ATOM   2342 N  N   . TYR B 1 68  ? 5.15142   13.90716  16.08000  1.000 8.75333  ?  68  TYR B N   1 
ATOM   2343 C  CA  . TYR B 1 68  ? 4.82108   14.22785  17.46772  1.000 15.13065 ?  68  TYR B CA  1 
ATOM   2344 C  C   . TYR B 1 68  ? 5.09874   13.04888  18.39114  1.000 15.81774 ?  68  TYR B C   1 
ATOM   2345 O  O   . TYR B 1 68  ? 4.84203   11.89880  18.03325  1.000 13.13069 ?  68  TYR B O   1 
ATOM   2346 C  CB  . TYR B 1 68  ? 3.34318   14.59613  17.58714  1.000 17.14656 ?  68  TYR B CB  1 
ATOM   2347 C  CG  . TYR B 1 68  ? 2.89942   15.83571  16.84320  1.000 14.72304 ?  68  TYR B CG  1 
ATOM   2348 C  CD1 . TYR B 1 68  ? 2.73882   15.83343  15.45902  1.000 12.82220 ?  68  TYR B CD1 1 
ATOM   2349 C  CD2 . TYR B 1 68  ? 2.60009   17.00158  17.53722  1.000 14.93325 ?  68  TYR B CD2 1 
ATOM   2350 C  CE1 . TYR B 1 68  ? 2.30698   16.98086  14.78573  1.000 15.96758 ?  68  TYR B CE1 1 
ATOM   2351 C  CE2 . TYR B 1 68  ? 2.16682   18.14504  16.87402  1.000 18.61984 ?  68  TYR B CE2 1 
ATOM   2352 C  CZ  . TYR B 1 68  ? 2.02188   18.12997  15.50717  1.000 16.11143 ?  68  TYR B CZ  1 
ATOM   2353 O  OH  . TYR B 1 68  ? 1.58635   19.27094  14.86272  1.000 15.53660 ?  68  TYR B OH  1 
ATOM   2354 N  N   . LYS B 1 69  ? 5.58699   13.33517  19.60245  1.000 15.13585 ?  69  LYS B N   1 
ATOM   2355 C  CA  . LYS B 1 69  ? 5.74435   12.25620  20.57439  1.000 17.25592 ?  69  LYS B CA  1 
ATOM   2356 C  C   . LYS B 1 69  ? 4.40325   11.61531  20.91577  1.000 15.89416 ?  69  LYS B C   1 
ATOM   2357 O  O   . LYS B 1 69  ? 4.34199   10.41745  21.21305  1.000 18.74749 ?  69  LYS B O   1 
ATOM   2358 C  CB  . LYS B 1 69  ? 6.42874   12.77439  21.84323  1.000 17.75578 ?  69  LYS B CB  1 
ATOM   2359 C  CG  . LYS B 1 69  ? 7.93078   13.03276  21.67911  1.000 21.83349 ?  69  LYS B CG  1 
ATOM   2360 C  CD  . LYS B 1 69  ? 8.59883   13.34676  23.02381  1.000 27.32380 ?  69  LYS B CD  1 
ATOM   2361 C  CE  . LYS B 1 69  ? 10.11216  13.51071  22.87156  1.000 33.17740 ?  69  LYS B CE  1 
ATOM   2362 N  NZ  . LYS B 1 69  ? 10.85991  13.18400  24.13150  1.000 28.24955 ?  69  LYS B NZ  1 
ATOM   2363 N  N   . LYS B 1 70  ? 3.31589   12.37603  20.84737  1.000 16.44878 ?  70  LYS B N   1 
ATOM   2364 C  CA  . LYS B 1 70  ? 2.00775   11.79397  21.13044  1.000 22.77150 ?  70  LYS B CA  1 
ATOM   2365 C  C   . LYS B 1 70  ? 1.62967   10.70975  20.13369  1.000 18.78189 ?  70  LYS B C   1 
ATOM   2366 O  O   . LYS B 1 70  ? 0.79608   9.86236   20.45564  1.000 24.71973 ?  70  LYS B O   1 
ATOM   2367 C  CB  . LYS B 1 70  ? 0.91882   12.87330  21.13745  1.000 23.44915 ?  70  LYS B CB  1 
ATOM   2368 C  CG  . LYS B 1 70  ? 0.66506   13.50107  19.76764  1.000 25.66395 ?  70  LYS B CG  1 
ATOM   2369 C  CD  . LYS B 1 70  ? -0.64459  14.28425  19.71167  1.000 31.03946 ?  70  LYS B CD  1 
ATOM   2370 C  CE  . LYS B 1 70  ? -0.47293  15.71313  20.20604  1.000 30.54656 ?  70  LYS B CE  1 
ATOM   2371 N  NZ  . LYS B 1 70  ? -1.31260  16.69731  19.43997  1.000 30.30231 ?  70  LYS B NZ  1 
ATOM   2372 N  N   . PHE B 1 71  ? 2.20066   10.72104  18.92539  1.000 15.97335 ?  71  PHE B N   1 
ATOM   2373 C  CA  . PHE B 1 71  ? 1.95282   9.65212   17.96703  1.000 14.86254 ?  71  PHE B CA  1 
ATOM   2374 C  C   . PHE B 1 71  ? 3.07191   8.63079   17.92229  1.000 19.22095 ?  71  PHE B C   1 
ATOM   2375 O  O   . PHE B 1 71  ? 2.80915   7.44033   17.76338  1.000 18.64781 ?  71  PHE B O   1 
ATOM   2376 C  CB  . PHE B 1 71  ? 1.74148   10.22466  16.56498  1.000 15.43592 ?  71  PHE B CB  1 
ATOM   2377 C  CG  . PHE B 1 71  ? 0.63558   11.22132  16.49412  1.000 15.82851 ?  71  PHE B CG  1 
ATOM   2378 C  CD1 . PHE B 1 71  ? -0.64643  10.87611  16.87840  1.000 17.62901 ?  71  PHE B CD1 1 
ATOM   2379 C  CD2 . PHE B 1 71  ? 0.87686   12.51004  16.05087  1.000 18.32186 ?  71  PHE B CD2 1 
ATOM   2380 C  CE1 . PHE B 1 71  ? -1.67283  11.80341  16.82062  1.000 18.38161 ?  71  PHE B CE1 1 
ATOM   2381 C  CE2 . PHE B 1 71  ? -0.14181  13.44353  15.98674  1.000 18.16044 ?  71  PHE B CE2 1 
ATOM   2382 C  CZ  . PHE B 1 71  ? -1.41785  13.09426  16.37460  1.000 16.95667 ?  71  PHE B CZ  1 
ATOM   2383 N  N   . ASN B 1 72  ? 4.32024   9.06006   18.05597  1.000 15.84036 ?  72  ASN B N   1 
ATOM   2384 C  CA  . ASN B 1 72  ? 5.46086   8.15400   18.02561  1.000 15.40243 ?  72  ASN B CA  1 
ATOM   2385 C  C   . ASN B 1 72  ? 6.36262   8.55374   19.18519  1.000 16.63429 ?  72  ASN B C   1 
ATOM   2386 O  O   . ASN B 1 72  ? 7.23865   9.41375   19.04013  1.000 15.39195 ?  72  ASN B O   1 
ATOM   2387 C  CB  . ASN B 1 72  ? 6.16722   8.21799   16.67701  1.000 20.04298 ?  72  ASN B CB  1 
ATOM   2388 C  CG  . ASN B 1 72  ? 7.43619   7.37183   16.62215  1.000 18.30733 ?  72  ASN B CG  1 
ATOM   2389 O  OD1 . ASN B 1 72  ? 7.83596   6.74413   17.60183  1.000 16.09775 ?  72  ASN B OD1 1 
ATOM   2390 N  ND2 . ASN B 1 72  ? 8.06686   7.34784   15.45540  1.000 22.03376 ?  72  ASN B ND2 1 
ATOM   2391 N  N   . PRO B 1 73  ? 6.17093   7.94912   20.35856  1.000 17.12423 ?  73  PRO B N   1 
ATOM   2392 C  CA  . PRO B 1 73  ? 6.98551   8.33691   21.51901  1.000 16.20266 ?  73  PRO B CA  1 
ATOM   2393 C  C   . PRO B 1 73  ? 8.45011   7.99545   21.36814  1.000 17.96641 ?  73  PRO B C   1 
ATOM   2394 O  O   . PRO B 1 73  ? 9.27755   8.60991   22.04944  1.000 18.00234 ?  73  PRO B O   1 
ATOM   2395 C  CB  . PRO B 1 73  ? 6.34750   7.55526   22.67558  1.000 23.19291 ?  73  PRO B CB  1 
ATOM   2396 C  CG  . PRO B 1 73  ? 5.58131   6.45901   22.02700  1.000 22.79422 ?  73  PRO B CG  1 
ATOM   2397 C  CD  . PRO B 1 73  ? 5.11515   6.99214   20.71413  1.000 12.61754 ?  73  PRO B CD  1 
ATOM   2398 N  N   . VAL B 1 74  ? 8.80052   7.04014   20.50105  1.000 17.61364 ?  74  VAL B N   1 
ATOM   2399 C  CA  . VAL B 1 74  ? 10.19918  6.65541   20.34154  1.000 15.57341 ?  74  VAL B CA  1 
ATOM   2400 C  C   . VAL B 1 74  ? 10.91959  7.58626   19.37079  1.000 17.77280 ?  74  VAL B C   1 
ATOM   2401 O  O   . VAL B 1 74  ? 12.10350  7.88847   19.54861  1.000 18.38111 ?  74  VAL B O   1 
ATOM   2402 C  CB  . VAL B 1 74  ? 10.29717  5.18617   19.89226  1.000 16.01180 ?  74  VAL B CB  1 
ATOM   2403 C  CG1 . VAL B 1 74  ? 11.73625  4.82084   19.61521  1.000 20.01993 ?  74  VAL B CG1 1 
ATOM   2404 C  CG2 . VAL B 1 74  ? 9.72912   4.26668   20.97139  1.000 17.27610 ?  74  VAL B CG2 1 
ATOM   2405 N  N   . GLY B 1 75  ? 10.24162  8.04064   18.32348  1.000 14.42434 ?  75  GLY B N   1 
ATOM   2406 C  CA  . GLY B 1 75  ? 10.92060  8.82789   17.30561  1.000 17.18316 ?  75  GLY B CA  1 
ATOM   2407 C  C   . GLY B 1 75  ? 10.34972  10.21190  17.06152  1.000 14.90238 ?  75  GLY B C   1 
ATOM   2408 O  O   . GLY B 1 75  ? 10.69980  10.87725  16.07876  1.000 11.73214 ?  75  GLY B O   1 
ATOM   2409 N  N   . GLY B 1 76  ? 9.45674   10.65531  17.94458  1.000 12.44149 ?  76  GLY B N   1 
ATOM   2410 C  CA  . GLY B 1 76  ? 8.81820   11.94359  17.77869  1.000 16.93007 ?  76  GLY B CA  1 
ATOM   2411 C  C   . GLY B 1 76  ? 9.57088   13.05633  18.46879  1.000 14.96973 ?  76  GLY B C   1 
ATOM   2412 O  O   . GLY B 1 76  ? 10.50917  12.82037  19.24057  1.000 16.59463 ?  76  GLY B O   1 
ATOM   2413 N  N   . GLY B 1 77  ? 9.15353   14.28156  18.15959  1.000 17.13648 ?  77  GLY B N   1 
ATOM   2414 C  CA  . GLY B 1 77  ? 9.68259   15.46560  18.80526  1.000 15.96199 ?  77  GLY B CA  1 
ATOM   2415 C  C   . GLY B 1 77  ? 11.10479  15.81892  18.44908  1.000 21.19879 ?  77  GLY B C   1 
ATOM   2416 O  O   . GLY B 1 77  ? 11.69403  16.68099  19.11312  1.000 18.08929 ?  77  GLY B O   1 
ATOM   2417 N  N   . ILE B 1 78  ? 11.68835  15.18476  17.43051  1.000 13.44250 ?  78  ILE B N   1 
ATOM   2418 C  CA  . ILE B 1 78  ? 13.05314  15.50319  17.02670  1.000 17.90262 ?  78  ILE B CA  1 
ATOM   2419 C  C   . ILE B 1 78  ? 13.10590  15.70719  15.52042  1.000 15.62517 ?  78  ILE B C   1 
ATOM   2420 O  O   . ILE B 1 78  ? 12.27622  15.18234  14.76970  1.000 13.38784 ?  78  ILE B O   1 
ATOM   2421 C  CB  . ILE B 1 78  ? 14.06854  14.41632  17.45214  1.000 18.08471 ?  78  ILE B CB  1 
ATOM   2422 C  CG1 . ILE B 1 78  ? 13.70792  13.05996  16.84606  1.000 17.00032 ?  78  ILE B CG1 1 
ATOM   2423 C  CG2 . ILE B 1 78  ? 14.14219  14.31569  18.96238  1.000 17.29221 ?  78  ILE B CG2 1 
ATOM   2424 C  CD1 . ILE B 1 78  ? 14.79949  12.04506  16.96869  1.000 18.34907 ?  78  ILE B CD1 1 
ATOM   2425 N  N   . ARG B 1 79  ? 14.08936  16.49016  15.08966  1.000 14.22849 ?  79  ARG B N   1 
ATOM   2426 C  CA  . ARG B 1 79  ? 14.40290  16.64944  13.67872  1.000 16.59723 ?  79  ARG B CA  1 
ATOM   2427 C  C   . ARG B 1 79  ? 15.16405  15.42118  13.20997  1.000 14.76413 ?  79  ARG B C   1 
ATOM   2428 O  O   . ARG B 1 79  ? 16.21859  15.08656  13.75853  1.000 13.42581 ?  79  ARG B O   1 
ATOM   2429 C  CB  . ARG B 1 79  ? 15.23500  17.91413  13.44714  1.000 12.99103 ?  79  ARG B CB  1 
ATOM   2430 C  CG  . ARG B 1 79  ? 14.47364  19.20167  13.73274  1.000 21.96901 ?  79  ARG B CG  1 
ATOM   2431 C  CD  . ARG B 1 79  ? 15.32241  20.44910  13.44515  1.000 27.79010 ?  79  ARG B CD  1 
ATOM   2432 N  NE  . ARG B 1 79  ? 14.46397  21.58670  13.14099  1.000 24.28233 ?  79  ARG B NE  1 
ATOM   2433 C  CZ  . ARG B 1 79  ? 13.88377  21.77240  11.96479  1.000 37.27955 ?  79  ARG B CZ  1 
ATOM   2434 N  NH1 . ARG B 1 79  ? 14.11810  20.95774  10.94079  1.000 31.70721 ?  79  ARG B NH1 1 
ATOM   2435 N  NH2 . ARG B 1 79  ? 13.04133  22.79199  11.81089  1.000 45.07637 ?  79  ARG B NH2 1 
ATOM   2436 N  N   . ARG B 1 80  ? 14.64051  14.75786  12.20026  1.000 13.07823 ?  80  ARG B N   1 
ATOM   2437 C  CA  . ARG B 1 80  ? 15.21648  13.52532  11.69294  1.000 13.47450 ?  80  ARG B CA  1 
ATOM   2438 C  C   . ARG B 1 80  ? 15.71687  13.79820  10.27859  1.000 17.42672 ?  80  ARG B C   1 
ATOM   2439 O  O   . ARG B 1 80  ? 14.91851  13.99958  9.36026   1.000 17.89665 ?  80  ARG B O   1 
ATOM   2440 C  CB  . ARG B 1 80  ? 14.18228  12.40103  11.77625  1.000 14.97859 ?  80  ARG B CB  1 
ATOM   2441 C  CG  . ARG B 1 80  ? 13.90999  12.05590  13.24981  1.000 13.80559 ?  80  ARG B CG  1 
ATOM   2442 C  CD  . ARG B 1 80  ? 12.72280  11.14175  13.49870  1.000 12.76427 ?  80  ARG B CD  1 
ATOM   2443 N  NE  . ARG B 1 80  ? 12.81717  9.86438   12.79928  1.000 12.14041 ?  80  ARG B NE  1 
ATOM   2444 C  CZ  . ARG B 1 80  ? 11.84898  8.95436   12.79376  1.000 18.95377 ?  80  ARG B CZ  1 
ATOM   2445 N  NH1 . ARG B 1 80  ? 10.75913  9.10704   13.52648  1.000 13.00354 ?  80  ARG B NH1 1 
ATOM   2446 N  NH2 . ARG B 1 80  ? 11.96881  7.87681   12.01778  1.000 11.56996 ?  80  ARG B NH2 1 
ATOM   2447 N  N   . VAL B 1 81  ? 17.03813  13.84735  10.12683  1.000 15.58428 ?  81  VAL B N   1 
ATOM   2448 C  CA  . VAL B 1 81  ? 17.69267  14.24192  8.88363   1.000 17.74710 ?  81  VAL B CA  1 
ATOM   2449 C  C   . VAL B 1 81  ? 17.84186  12.99546  8.02589   1.000 17.81157 ?  81  VAL B C   1 
ATOM   2450 O  O   . VAL B 1 81  ? 18.63181  12.10271  8.34051   1.000 17.81213 ?  81  VAL B O   1 
ATOM   2451 C  CB  . VAL B 1 81  ? 19.05910  14.88292  9.14934   1.000 17.83521 ?  81  VAL B CB  1 
ATOM   2452 C  CG1 . VAL B 1 81  ? 19.67150  15.35956  7.83915   1.000 24.28607 ?  81  VAL B CG1 1 
ATOM   2453 C  CG2 . VAL B 1 81  ? 18.92817  16.01116  10.14684  1.000 18.23866 ?  81  VAL B CG2 1 
ATOM   2454 N  N   . TYR B 1 82  ? 17.06706  12.92452  6.95436   1.000 17.49176 ?  82  TYR B N   1 
ATOM   2455 C  CA  . TYR B 1 82  ? 17.06563  11.78445  6.05624   1.000 19.32695 ?  82  TYR B CA  1 
ATOM   2456 C  C   . TYR B 1 82  ? 17.41433  12.26438  4.65417   1.000 22.21745 ?  82  TYR B C   1 
ATOM   2457 O  O   . TYR B 1 82  ? 17.25577  13.44058  4.32184   1.000 19.17581 ?  82  TYR B O   1 
ATOM   2458 C  CB  . TYR B 1 82  ? 15.69703  11.07912  6.06078   1.000 12.49733 ?  82  TYR B CB  1 
ATOM   2459 C  CG  . TYR B 1 82  ? 15.38602  10.37241  7.36856   1.000 16.78732 ?  82  TYR B CG  1 
ATOM   2460 C  CD1 . TYR B 1 82  ? 16.29311  9.47495   7.94661   1.000 15.17157 ?  82  TYR B CD1 1 
ATOM   2461 C  CD2 . TYR B 1 82  ? 14.19281  10.60131  8.02535   1.000 16.07936 ?  82  TYR B CD2 1 
ATOM   2462 C  CE1 . TYR B 1 82  ? 16.00391  8.82773   9.14008   1.000 14.81170 ?  82  TYR B CE1 1 
ATOM   2463 C  CE2 . TYR B 1 82  ? 13.89456  9.95897   9.20815   1.000 14.31172 ?  82  TYR B CE2 1 
ATOM   2464 C  CZ  . TYR B 1 82  ? 14.78728  9.07961   9.76617   1.000 13.62431 ?  82  TYR B CZ  1 
ATOM   2465 O  OH  . TYR B 1 82  ? 14.45957  8.45451   10.95571  1.000 15.42931 ?  82  TYR B OH  1 
ATOM   2466 N  N   . GLU B 1 83  ? 17.89509  11.37617  3.86613   1.000 16.96021 ?  83  GLU B N   1 
ATOM   2467 C  CA  . GLU B 1 83  ? 18.12917  11.74863  2.47921   1.000 19.97680 ?  83  GLU B CA  1 
ATOM   2468 C  C   . GLU B 1 83  ? 16.85269  11.59457  1.65603   1.000 19.54827 ?  83  GLU B C   1 
ATOM   2469 O  O   . GLU B 1 83  ? 15.95866  10.81408  2.01858   1.000 18.90062 ?  83  GLU B O   1 
ATOM   2470 C  CB  . GLU B 1 83  ? 19.23522  10.88721  1.88132   1.000 23.40731 ?  83  GLU B CB  1 
ATOM   2471 C  CG  . GLU B 1 83  ? 20.58094  11.07746  2.56512   1.000 23.88944 ?  83  GLU B CG  1 
ATOM   2472 C  CD  . GLU B 1 83  ? 21.11731  12.48354  2.38231   1.000 37.33780 ?  83  GLU B CD  1 
ATOM   2473 O  OE1 . GLU B 1 83  ? 21.30899  12.88072  1.21176   1.000 37.81292 ?  83  GLU B OE1 1 
ATOM   2474 O  OE2 . GLU B 1 83  ? 21.32539  13.19419  3.39750   1.000 41.74942 -1 83  GLU B OE2 1 
ATOM   2475 N  N   . PRO B 1 84  ? 16.73471  12.32402  0.54478   1.000 18.69386 ?  84  PRO B N   1 
ATOM   2476 C  CA  . PRO B 1 84  ? 15.54597  12.17389  -0.30329  1.000 17.29267 ?  84  PRO B CA  1 
ATOM   2477 C  C   . PRO B 1 84  ? 15.47589  10.79634  -0.94012  1.000 15.87705 ?  84  PRO B C   1 
ATOM   2478 O  O   . PRO B 1 84  ? 16.48058  10.10813  -1.13965  1.000 15.10819 ?  84  PRO B O   1 
ATOM   2479 C  CB  . PRO B 1 84  ? 15.71485  13.26398  -1.37559  1.000 16.59416 ?  84  PRO B CB  1 
ATOM   2480 C  CG  . PRO B 1 84  ? 17.17390  13.61399  -1.34528  1.000 21.04720 ?  84  PRO B CG  1 
ATOM   2481 C  CD  . PRO B 1 84  ? 17.61534  13.40910  0.07378   1.000 17.32958 ?  84  PRO B CD  1 
ATOM   2482 N  N   . ILE B 1 85  ? 14.24404  10.39784  -1.24531  1.000 11.96787 ?  85  ILE B N   1 
ATOM   2483 C  CA  . ILE B 1 85  ? 13.99022  9.22480   -2.07093  1.000 14.62437 ?  85  ILE B CA  1 
ATOM   2484 C  C   . ILE B 1 85  ? 14.48620  9.49263   -3.48528  1.000 19.41955 ?  85  ILE B C   1 
ATOM   2485 O  O   . ILE B 1 85  ? 14.29593  10.58671  -4.03487  1.000 17.47173 ?  85  ILE B O   1 
ATOM   2486 C  CB  . ILE B 1 85  ? 12.48548  8.90434   -2.05659  1.000 19.75476 ?  85  ILE B CB  1 
ATOM   2487 C  CG1 . ILE B 1 85  ? 12.05555  8.52700   -0.63474  1.000 13.30001 ?  85  ILE B CG1 1 
ATOM   2488 C  CG2 . ILE B 1 85  ? 12.14161  7.80981   -3.05732  1.000 17.30148 ?  85  ILE B CG2 1 
ATOM   2489 C  CD1 . ILE B 1 85  ? 10.57669  8.39904   -0.47025  1.000 15.23276 ?  85  ILE B CD1 1 
ATOM   2490 N  N   . GLU B 1 86  ? 15.15648  8.50639   -4.06926  1.000 20.13573 ?  86  GLU B N   1 
ATOM   2491 C  CA  . GLU B 1 86  ? 15.66592  8.68853   -5.41906  1.000 22.11977 ?  86  GLU B CA  1 
ATOM   2492 C  C   . GLU B 1 86  ? 14.60936  8.34034   -6.45322  1.000 23.76698 ?  86  GLU B C   1 
ATOM   2493 O  O   . GLU B 1 86  ? 14.45123  9.05286   -7.44652  1.000 22.68127 ?  86  GLU B O   1 
ATOM   2494 C  CB  . GLU B 1 86  ? 16.90997  7.83179   -5.62602  1.000 20.76351 ?  86  GLU B CB  1 
ATOM   2495 C  CG  . GLU B 1 86  ? 18.03688  8.18160   -4.67710  1.000 22.39164 ?  86  GLU B CG  1 
ATOM   2496 C  CD  . GLU B 1 86  ? 19.27877  7.35509   -4.92576  1.000 27.43933 ?  86  GLU B CD  1 
ATOM   2497 O  OE1 . GLU B 1 86  ? 19.19276  6.11124   -4.86297  1.000 33.20380 ?  86  GLU B OE1 1 
ATOM   2498 O  OE2 . GLU B 1 86  ? 20.34200  7.95191   -5.19164  1.000 34.53155 -1 86  GLU B OE2 1 
ATOM   2499 N  N   . VAL B 1 87  ? 13.86985  7.25760   -6.22759  1.000 21.35920 ?  87  VAL B N   1 
ATOM   2500 C  CA  . VAL B 1 87  ? 12.97716  6.72286   -7.24433  1.000 21.74780 ?  87  VAL B CA  1 
ATOM   2501 C  C   . VAL B 1 87  ? 11.63732  7.42734   -7.16168  1.000 22.55278 ?  87  VAL B C   1 
ATOM   2502 O  O   . VAL B 1 87  ? 11.46745  8.37200   -6.38372  1.000 22.72223 ?  87  VAL B O   1 
ATOM   2503 C  CB  . VAL B 1 87  ? 12.83151  5.19979   -7.08908  1.000 20.57006 ?  87  VAL B CB  1 
ATOM   2504 C  CG1 . VAL B 1 87  ? 14.16745  4.53776   -7.34891  1.000 21.59180 ?  87  VAL B CG1 1 
ATOM   2505 C  CG2 . VAL B 1 87  ? 12.34786  4.85596   -5.69385  1.000 18.84680 ?  87  VAL B CG2 1 
ATOM   2506 N  N   . ASP B 1 88  ? 10.67562  6.96433   -7.94450  1.000 19.95970 ?  88  ASP B N   1 
ATOM   2507 C  CA  . ASP B 1 88  ? 9.38613   7.62868   -8.07775  1.000 22.27786 ?  88  ASP B CA  1 
ATOM   2508 C  C   . ASP B 1 88  ? 8.28646   6.66855   -7.64468  1.000 21.31353 ?  88  ASP B C   1 
ATOM   2509 O  O   . ASP B 1 88  ? 7.83029   5.82917   -8.42555  1.000 20.50693 ?  88  ASP B O   1 
ATOM   2510 C  CB  . ASP B 1 88  ? 9.17136   8.10064   -9.51021  1.000 24.33232 ?  88  ASP B CB  1 
ATOM   2511 C  CG  . ASP B 1 88  ? 7.78733   8.66982   -9.72953  1.000 25.29476 ?  88  ASP B CG  1 
ATOM   2512 O  OD1 . ASP B 1 88  ? 7.16365   9.13729   -8.75073  1.000 34.88380 ?  88  ASP B OD1 1 
ATOM   2513 O  OD2 . ASP B 1 88  ? 7.31177   8.63251   -10.88187 1.000 36.63770 -1 88  ASP B OD2 1 
ATOM   2514 N  N   . PHE B 1 89  ? 7.83016   6.81876   -6.41596  1.000 18.73720 ?  89  PHE B N   1 
ATOM   2515 C  CA  . PHE B 1 89  ? 6.73854   6.00793   -5.90770  1.000 20.59509 ?  89  PHE B CA  1 
ATOM   2516 C  C   . PHE B 1 89  ? 5.36732   6.53802   -6.28891  1.000 20.77867 ?  89  PHE B C   1 
ATOM   2517 O  O   . PHE B 1 89  ? 4.36217   5.93943   -5.88709  1.000 18.83653 ?  89  PHE B O   1 
ATOM   2518 C  CB  . PHE B 1 89  ? 6.83807   5.89094   -4.37803  1.000 17.89823 ?  89  PHE B CB  1 
ATOM   2519 C  CG  . PHE B 1 89  ? 7.95026   5.00339   -3.92332  1.000 17.37728 ?  89  PHE B CG  1 
ATOM   2520 C  CD1 . PHE B 1 89  ? 7.87811   3.63314   -4.12643  1.000 19.81054 ?  89  PHE B CD1 1 
ATOM   2521 C  CD2 . PHE B 1 89  ? 9.06830   5.53480   -3.30746  1.000 16.37475 ?  89  PHE B CD2 1 
ATOM   2522 C  CE1 . PHE B 1 89  ? 8.91279   2.79933   -3.72299  1.000 21.54440 ?  89  PHE B CE1 1 
ATOM   2523 C  CE2 . PHE B 1 89  ? 10.10671  4.71889   -2.88596  1.000 14.35273 ?  89  PHE B CE2 1 
ATOM   2524 C  CZ  . PHE B 1 89  ? 10.03372  3.34270   -3.10056  1.000 17.92380 ?  89  PHE B CZ  1 
ATOM   2525 N  N   . THR B 1 90  ? 5.28700   7.63124   -7.05596  1.000 20.96108 ?  90  THR B N   1 
ATOM   2526 C  CA  . THR B 1 90  ? 3.97818   8.25123   -7.24901  1.000 22.27912 ?  90  THR B CA  1 
ATOM   2527 C  C   . THR B 1 90  ? 2.98249   7.38062   -8.02502  1.000 20.52851 ?  90  THR B C   1 
ATOM   2528 O  O   . THR B 1 90  ? 1.78575   7.40968   -7.70376  1.000 20.75812 ?  90  THR B O   1 
ATOM   2529 C  CB  . THR B 1 90  ? 4.11163   9.62673   -7.91854  1.000 25.35803 ?  90  THR B CB  1 
ATOM   2530 O  OG1 . THR B 1 90  ? 4.71270   9.49904   -9.21324  1.000 23.59989 ?  90  THR B OG1 1 
ATOM   2531 C  CG2 . THR B 1 90  ? 4.96599   10.55327  -7.05747  1.000 22.44672 ?  90  THR B CG2 1 
ATOM   2532 N  N   . PRO B 1 91  ? 3.38644   6.58424   -9.02366  1.000 27.17582 ?  91  PRO B N   1 
ATOM   2533 C  CA  . PRO B 1 91  ? 2.37604   5.69986   -9.64069  1.000 24.17596 ?  91  PRO B CA  1 
ATOM   2534 C  C   . PRO B 1 91  ? 1.80268   4.67398   -8.66825  1.000 22.19637 ?  91  PRO B C   1 
ATOM   2535 O  O   . PRO B 1 91  ? 0.58976   4.42598   -8.65766  1.000 21.00808 ?  91  PRO B O   1 
ATOM   2536 C  CB  . PRO B 1 91  ? 3.13278   5.04481   -10.81099 1.000 27.18018 ?  91  PRO B CB  1 
ATOM   2537 C  CG  . PRO B 1 91  ? 4.55718   5.32875   -10.60925 1.000 27.27564 ?  91  PRO B CG  1 
ATOM   2538 C  CD  . PRO B 1 91  ? 4.65793   6.56545   -9.77445  1.000 26.06905 ?  91  PRO B CD  1 
ATOM   2539 N  N   . LEU B 1 92  ? 2.64706   4.06687   -7.84391  1.000 22.58483 ?  92  LEU B N   1 
ATOM   2540 C  CA  . LEU B 1 92  ? 2.14547   3.23199   -6.75965  1.000 20.24321 ?  92  LEU B CA  1 
ATOM   2541 C  C   . LEU B 1 92  ? 1.19705   4.01082   -5.84894  1.000 19.23397 ?  92  LEU B C   1 
ATOM   2542 O  O   . LEU B 1 92  ? 0.10453   3.52935   -5.53068  1.000 24.28840 ?  92  LEU B O   1 
ATOM   2543 C  CB  . LEU B 1 92  ? 3.33742   2.66939   -5.98480  1.000 24.19409 ?  92  LEU B CB  1 
ATOM   2544 C  CG  . LEU B 1 92  ? 3.23269   1.68721   -4.82880  1.000 27.07853 ?  92  LEU B CG  1 
ATOM   2545 C  CD1 . LEU B 1 92  ? 4.57449   0.98248   -4.65699  1.000 20.92739 ?  92  LEU B CD1 1 
ATOM   2546 C  CD2 . LEU B 1 92  ? 2.89608   2.43465   -3.57359  1.000 22.29625 ?  92  LEU B CD2 1 
ATOM   2547 N  N   . ILE B 1 93  ? 1.58967   5.21708   -5.42616  1.000 17.88134 ?  93  ILE B N   1 
ATOM   2548 C  CA  . ILE B 1 93  ? 0.73971   6.01450   -4.54165  1.000 19.38017 ?  93  ILE B CA  1 
ATOM   2549 C  C   . ILE B 1 93  ? -0.60479  6.32029   -5.19543  1.000 21.26360 ?  93  ILE B C   1 
ATOM   2550 O  O   . ILE B 1 93  ? -1.64326  6.32419   -4.52401  1.000 23.61150 ?  93  ILE B O   1 
ATOM   2551 C  CB  . ILE B 1 93  ? 1.46062   7.30876   -4.11417  1.000 16.09203 ?  93  ILE B CB  1 
ATOM   2552 C  CG1 . ILE B 1 93  ? 2.70019   6.97196   -3.28031  1.000 18.28656 ?  93  ILE B CG1 1 
ATOM   2553 C  CG2 . ILE B 1 93  ? 0.52973   8.18861   -3.30639  1.000 15.44087 ?  93  ILE B CG2 1 
ATOM   2554 C  CD1 . ILE B 1 93  ? 3.76942   8.05084   -3.32355  1.000 19.13540 ?  93  ILE B CD1 1 
ATOM   2555 N  N   . SER B 1 94  ? -0.60853  6.59898   -6.50668  1.000 19.72760 ?  94  SER B N   1 
ATOM   2556 C  CA  . SER B 1 94  ? -1.86532  6.86440   -7.20624  1.000 22.85646 ?  94  SER B CA  1 
ATOM   2557 C  C   . SER B 1 94  ? -2.88606  5.75740   -6.98688  1.000 21.30476 ?  94  SER B C   1 
ATOM   2558 O  O   . SER B 1 94  ? -4.08978  6.03254   -6.89529  1.000 21.62099 ?  94  SER B O   1 
ATOM   2559 C  CB  . SER B 1 94  ? -1.61975  7.03947   -8.70923  1.000 23.44453 ?  94  SER B CB  1 
ATOM   2560 O  OG  . SER B 1 94  ? -1.00960  8.28233   -8.98377  1.000 24.67886 ?  94  SER B OG  1 
ATOM   2561 N  N   . GLU B 1 95  ? -2.43554  4.50248   -6.90915  1.000 22.49014 ?  95  GLU B N   1 
ATOM   2562 C  CA  . GLU B 1 95  ? -3.37223  3.41126   -6.66712  1.000 26.54946 ?  95  GLU B CA  1 
ATOM   2563 C  C   . GLU B 1 95  ? -4.07594  3.58192   -5.33068  1.000 25.37109 ?  95  GLU B C   1 
ATOM   2564 O  O   . GLU B 1 95  ? -5.27537  3.30942   -5.21091  1.000 26.80078 ?  95  GLU B O   1 
ATOM   2565 C  CB  . GLU B 1 95  ? -2.65009  2.06607   -6.71001  1.000 23.42005 ?  95  GLU B CB  1 
ATOM   2566 C  CG  . GLU B 1 95  ? -3.52349  0.94494   -7.21162  1.000 36.56380 ?  95  GLU B CG  1 
ATOM   2567 C  CD  . GLU B 1 95  ? -3.35170  0.71419   -8.70498  1.000 44.15638 ?  95  GLU B CD  1 
ATOM   2568 O  OE1 . GLU B 1 95  ? -2.96261  1.66881   -9.41109  1.000 49.90380 ?  95  GLU B OE1 1 
ATOM   2569 O  OE2 . GLU B 1 95  ? -3.58169  -0.42612  -9.16689  1.000 56.12004 -1 95  GLU B OE2 1 
ATOM   2570 N  N   . GLY B 1 96  ? -3.34061  4.01657   -4.30732  1.000 28.46198 ?  96  GLY B N   1 
ATOM   2571 C  CA  . GLY B 1 96  ? -3.95818  4.23727   -3.01295  1.000 27.27532 ?  96  GLY B CA  1 
ATOM   2572 C  C   . GLY B 1 96  ? -4.91966  5.40875   -3.01973  1.000 25.25534 ?  96  GLY B C   1 
ATOM   2573 O  O   . GLY B 1 96  ? -5.99360  5.34072   -2.41709  1.000 25.62825 ?  96  GLY B O   1 
ATOM   2574 N  N   . ILE B 1 97  ? -4.53962  6.50337   -3.68244  1.000 19.04224 ?  97  ILE B N   1 
ATOM   2575 C  CA  . ILE B 1 97  ? -5.44606  7.63823   -3.83430  1.000 27.16616 ?  97  ILE B CA  1 
ATOM   2576 C  C   . ILE B 1 97  ? -6.74513  7.18452   -4.48413  1.000 26.89334 ?  97  ILE B C   1 
ATOM   2577 O  O   . ILE B 1 97  ? -7.84317  7.57206   -4.06401  1.000 28.43260 ?  97  ILE B O   1 
ATOM   2578 C  CB  . ILE B 1 97  ? -4.76224  8.74791   -4.65323  1.000 25.68625 ?  97  ILE B CB  1 
ATOM   2579 C  CG1 . ILE B 1 97  ? -3.45724  9.16909   -3.99080  1.000 22.76192 ?  97  ILE B CG1 1 
ATOM   2580 C  CG2 . ILE B 1 97  ? -5.67214  9.94779   -4.81466  1.000 23.47811 ?  97  ILE B CG2 1 
ATOM   2581 C  CD1 . ILE B 1 97  ? -2.72356  10.22536  -4.77743  1.000 25.41814 ?  97  ILE B CD1 1 
ATOM   2582 N  N   . ARG B 1 98  ? -6.63896  6.32365   -5.49613  1.000 23.88246 ?  98  ARG B N   1 
ATOM   2583 C  CA  . ARG B 1 98  ? -7.82765  5.83953   -6.19482  1.000 28.82891 ?  98  ARG B CA  1 
ATOM   2584 C  C   . ARG B 1 98  ? -8.70081  4.99585   -5.27959  1.000 27.97244 ?  98  ARG B C   1 
ATOM   2585 O  O   . ARG B 1 98  ? -9.92345  5.17227   -5.23179  1.000 26.17146 ?  98  ARG B O   1 
ATOM   2586 C  CB  . ARG B 1 98  ? -7.39783  5.04017   -7.41944  1.000 30.51913 ?  98  ARG B CB  1 
ATOM   2587 C  CG  . ARG B 1 98  ? -8.49566  4.27108   -8.11547  1.000 28.98157 ?  98  ARG B CG  1 
ATOM   2588 C  CD  . ARG B 1 98  ? -7.87830  3.23950   -9.06985  1.000 41.38083 ?  98  ARG B CD  1 
ATOM   2589 N  NE  . ARG B 1 98  ? -6.53795  3.62041   -9.51475  1.000 47.90447 ?  98  ARG B NE  1 
ATOM   2590 C  CZ  . ARG B 1 98  ? -6.28060  4.52705   -10.45131 1.000 49.42357 ?  98  ARG B CZ  1 
ATOM   2591 N  NH1 . ARG B 1 98  ? -7.25620  5.17164   -11.07244 1.000 51.35414 ?  98  ARG B NH1 1 
ATOM   2592 N  NH2 . ARG B 1 98  ? -5.01284  4.80016   -10.76395 1.000 38.07019 ?  98  ARG B NH2 1 
ATOM   2593 N  N   . GLU B 1 99  ? -8.08418  4.09713   -4.51901  1.000 26.67205 ?  99  GLU B N   1 
ATOM   2594 C  CA  . GLU B 1 99  ? -8.84815  3.25612   -3.61146  1.000 24.44592 ?  99  GLU B CA  1 
ATOM   2595 C  C   . GLU B 1 99  ? -9.38247  4.04505   -2.41533  1.000 25.61340 ?  99  GLU B C   1 
ATOM   2596 O  O   . GLU B 1 99  ? -10.47261 3.75155   -1.92757  1.000 28.30682 ?  99  GLU B O   1 
ATOM   2597 C  CB  . GLU B 1 99  ? -7.97683  2.09127   -3.15790  1.000 22.16679 ?  99  GLU B CB  1 
ATOM   2598 C  CG  . GLU B 1 99  ? -8.69958  1.06763   -2.33650  1.000 30.48784 ?  99  GLU B CG  1 
ATOM   2599 C  CD  . GLU B 1 99  ? -9.56221  0.16664   -3.16931  1.000 35.07068 ?  99  GLU B CD  1 
ATOM   2600 O  OE1 . GLU B 1 99  ? -9.26288  -0.00094  -4.37025  1.000 42.63174 ?  99  GLU B OE1 1 
ATOM   2601 O  OE2 . GLU B 1 99  ? -10.54662 -0.36840  -2.62428  1.000 42.27239 -1 99  GLU B OE2 1 
ATOM   2602 N  N   . LEU B 1 100 ? -8.64247  5.04327   -1.92561  1.000 21.72903 ?  100 LEU B N   1 
ATOM   2603 C  CA  . LEU B 1 100 ? -9.16990  5.91563   -0.87631  1.000 16.94109 ?  100 LEU B CA  1 
ATOM   2604 C  C   . LEU B 1 100 ? -10.29356 6.80963   -1.38187  1.000 26.36089 ?  100 LEU B C   1 
ATOM   2605 O  O   . LEU B 1 100 ? -11.17831 7.19280   -0.60393  1.000 23.55782 ?  100 LEU B O   1 
ATOM   2606 C  CB  . LEU B 1 100 ? -8.05546  6.79867   -0.31898  1.000 21.04446 ?  100 LEU B CB  1 
ATOM   2607 C  CG  . LEU B 1 100 ? -6.99039  6.12116   0.54303   1.000 19.21629 ?  100 LEU B CG  1 
ATOM   2608 C  CD1 . LEU B 1 100 ? -5.87112  7.11439   0.81866   1.000 19.02808 ?  100 LEU B CD1 1 
ATOM   2609 C  CD2 . LEU B 1 100 ? -7.59749  5.61723   1.83068   1.000 18.94437 ?  100 LEU B CD2 1 
ATOM   2610 N  N   . GLY B 1 101 ? -10.27022 7.15791   -2.66992  1.000 26.08351 ?  101 GLY B N   1 
ATOM   2611 C  CA  . GLY B 1 101 ? -11.14492 8.19366   -3.17275  1.000 29.74358 ?  101 GLY B CA  1 
ATOM   2612 C  C   . GLY B 1 101 ? -10.93031 9.47654   -2.39880  1.000 28.42413 ?  101 GLY B C   1 
ATOM   2613 O  O   . GLY B 1 101 ? -11.87691 10.02339  -1.82376  1.000 25.44115 ?  101 GLY B O   1 
ATOM   2614 N  N   . LEU B 1 102 ? -9.67684  9.93754   -2.35452  1.000 31.72961 ?  102 LEU B N   1 
ATOM   2615 C  CA  . LEU B 1 102 ? -9.32027  11.15371  -1.62722  1.000 28.74038 ?  102 LEU B CA  1 
ATOM   2616 C  C   . LEU B 1 102 ? -10.21079 12.32292  -2.03069  1.000 23.50732 ?  102 LEU B C   1 
ATOM   2617 O  O   . LEU B 1 102 ? -10.51149 12.50785  -3.21381  1.000 24.85177 ?  102 LEU B O   1 
ATOM   2618 C  CB  . LEU B 1 102 ? -7.86220  11.51271  -1.90637  1.000 30.86380 ?  102 LEU B CB  1 
ATOM   2619 C  CG  . LEU B 1 102 ? -6.71092  11.14693  -0.97691  1.000 28.01946 ?  102 LEU B CG  1 
ATOM   2620 C  CD1 . LEU B 1 102 ? -5.50530  11.97111  -1.38668  1.000 20.06348 ?  102 LEU B CD1 1 
ATOM   2621 C  CD2 . LEU B 1 102 ? -7.03644  11.36202  0.48952   1.000 22.12695 ?  102 LEU B CD2 1 
ATOM   2622 N  N   . ASP B 1 103 ? -10.62119 13.11065  -1.03292  1.000 21.78338 ?  103 ASP B N   1 
ATOM   2623 C  CA  . ASP B 1 103 ? -11.47479 14.28506  -1.19695  1.000 28.73393 ?  103 ASP B CA  1 
ATOM   2624 C  C   . ASP B 1 103 ? -10.85706 15.27565  -2.17785  1.000 29.21095 ?  103 ASP B C   1 
ATOM   2625 O  O   . ASP B 1 103 ? -9.83560  15.90426  -1.88024  1.000 25.26297 ?  103 ASP B O   1 
ATOM   2626 C  CB  . ASP B 1 103 ? -11.70985 14.94704  0.16675   1.000 25.59782 ?  103 ASP B CB  1 
ATOM   2627 C  CG  . ASP B 1 103 ? -12.69965 16.09479  0.10846   1.000 23.53979 ?  103 ASP B CG  1 
ATOM   2628 O  OD1 . ASP B 1 103 ? -13.15776 16.43909  -1.00495  1.000 25.56142 ?  103 ASP B OD1 1 
ATOM   2629 O  OD2 . ASP B 1 103 ? -13.03024 16.64035  1.18509   1.000 24.48249 -1 103 ASP B OD2 1 
ATOM   2630 N  N   . ARG B 1 104 ? -11.47465 15.43038  -3.34575  1.000 28.65361 ?  104 ARG B N   1 
ATOM   2631 C  CA  . ARG B 1 104 ? -10.92260 16.28582  -4.38769  1.000 25.69805 ?  104 ARG B CA  1 
ATOM   2632 C  C   . ARG B 1 104 ? -11.15380 17.76245  -4.11639  1.000 26.20999 ?  104 ARG B C   1 
ATOM   2633 O  O   . ARG B 1 104 ? -10.67214 18.59490  -4.88965  1.000 29.94458 ?  104 ARG B O   1 
ATOM   2634 C  CB  . ARG B 1 104 ? -11.51517 15.91687  -5.75425  1.000 26.88827 ?  104 ARG B CB  1 
ATOM   2635 C  CG  . ARG B 1 104 ? -11.04628 14.57588  -6.28269  1.000 31.64445 ?  104 ARG B CG  1 
ATOM   2636 C  CD  . ARG B 1 104 ? -11.57021 14.34721  -7.68309  1.000 38.40690 ?  104 ARG B CD  1 
ATOM   2637 N  NE  . ARG B 1 104 ? -11.04395 15.34219  -8.60842  1.000 47.50563 ?  104 ARG B NE  1 
ATOM   2638 C  CZ  . ARG B 1 104 ? -9.94905  15.17681  -9.33819  1.000 48.24270 ?  104 ARG B CZ  1 
ATOM   2639 N  NH1 . ARG B 1 104 ? -9.24971  14.05627  -9.29008  1.000 42.30550 ?  104 ARG B NH1 1 
ATOM   2640 N  NH2 . ARG B 1 104 ? -9.54850  16.15915  -10.13967 1.000 53.40194 ?  104 ARG B NH2 1 
ATOM   2641 N  N   . SER B 1 105 ? -11.84777 18.10359  -3.02957  1.000 22.37312 ?  105 SER B N   1 
ATOM   2642 C  CA  . SER B 1 105 ? -12.26334 19.47446  -2.77739  1.000 23.42556 ?  105 SER B CA  1 
ATOM   2643 C  C   . SER B 1 105 ? -11.16817 20.36304  -2.19487  1.000 25.88859 ?  105 SER B C   1 
ATOM   2644 O  O   . SER B 1 105 ? -11.36452 21.57923  -2.11583  1.000 23.39568 ?  105 SER B O   1 
ATOM   2645 C  CB  . SER B 1 105 ? -13.46747 19.47216  -1.84173  1.000 25.23140 ?  105 SER B CB  1 
ATOM   2646 O  OG  . SER B 1 105 ? -14.55066 18.79679  -2.44600  1.000 38.09966 ?  105 SER B OG  1 
ATOM   2647 N  N   . GLU B 1 106 ? -10.03737 19.80792  -1.76887  1.000 28.11126 ?  106 GLU B N   1 
ATOM   2648 C  CA  . GLU B 1 106 ? -8.91401  20.62467  -1.32501  1.000 22.57941 ?  106 GLU B CA  1 
ATOM   2649 C  C   . GLU B 1 106 ? -7.64763  19.83587  -1.58006  1.000 23.70480 ?  106 GLU B C   1 
ATOM   2650 O  O   . GLU B 1 106 ? -7.70836  18.60950  -1.71950  1.000 22.48780 ?  106 GLU B O   1 
ATOM   2651 C  CB  . GLU B 1 106 ? -9.02271  21.00763  0.15865   1.000 24.84873 ?  106 GLU B CB  1 
ATOM   2652 C  CG  . GLU B 1 106 ? -9.03975  19.83678  1.12025   1.000 22.49952 ?  106 GLU B CG  1 
ATOM   2653 C  CD  . GLU B 1 106 ? -9.29016  20.28082  2.55072   1.000 25.88295 ?  106 GLU B CD  1 
ATOM   2654 O  OE1 . GLU B 1 106 ? -8.41879  20.96456  3.12243   1.000 24.63432 ?  106 GLU B OE1 1 
ATOM   2655 O  OE2 . GLU B 1 106 ? -10.36642 19.97030  3.10371   1.000 23.80954 -1 106 GLU B OE2 1 
ATOM   2656 N  N   . PRO B 1 107 ? -6.49727  20.49285  -1.69738  1.000 23.33381 ?  107 PRO B N   1 
ATOM   2657 C  CA  . PRO B 1 107 ? -5.26175  19.75775  -1.95610  1.000 19.28334 ?  107 PRO B CA  1 
ATOM   2658 C  C   . PRO B 1 107 ? -4.81046  19.00662  -0.71206  1.000 18.62688 ?  107 PRO B C   1 
ATOM   2659 O  O   . PRO B 1 107 ? -5.29739  19.23156  0.39863   1.000 16.76915 ?  107 PRO B O   1 
ATOM   2660 C  CB  . PRO B 1 107 ? -4.26367  20.85286  -2.34940  1.000 22.02505 ?  107 PRO B CB  1 
ATOM   2661 C  CG  . PRO B 1 107 ? -4.75750  22.07072  -1.66399  1.000 20.83484 ?  107 PRO B CG  1 
ATOM   2662 C  CD  . PRO B 1 107 ? -6.27475  21.95072  -1.69995  1.000 24.44375 ?  107 PRO B CD  1 
ATOM   2663 N  N   . TRP B 1 108 ? -3.87556  18.08020  -0.92753  1.000 21.59390 ?  108 TRP B N   1 
ATOM   2664 C  CA  . TRP B 1 108 ? -3.38234  17.19193  0.11438   1.000 16.11436 ?  108 TRP B CA  1 
ATOM   2665 C  C   . TRP B 1 108 ? -1.86549  17.27065  0.16349   1.000 19.13255 ?  108 TRP B C   1 
ATOM   2666 O  O   . TRP B 1 108 ? -1.21435  17.74382  -0.77705  1.000 16.33937 ?  108 TRP B O   1 
ATOM   2667 C  CB  . TRP B 1 108 ? -3.84058  15.74300  -0.12754  1.000 12.50205 ?  108 TRP B CB  1 
ATOM   2668 C  CG  . TRP B 1 108 ? -5.28344  15.53900  0.12009   1.000 17.62976 ?  108 TRP B CG  1 
ATOM   2669 C  CD1 . TRP B 1 108 ? -6.31451  15.97860  -0.65866  1.000 20.59322 ?  108 TRP B CD1 1 
ATOM   2670 C  CD2 . TRP B 1 108 ? -5.88077  14.84601  1.22444   1.000 17.10942 ?  108 TRP B CD2 1 
ATOM   2671 N  NE1 . TRP B 1 108 ? -7.51703  15.59649  -0.11305  1.000 23.67120 ?  108 TRP B NE1 1 
ATOM   2672 C  CE2 . TRP B 1 108 ? -7.27947  14.90438  1.04639   1.000 19.32763 ?  108 TRP B CE2 1 
ATOM   2673 C  CE3 . TRP B 1 108 ? -5.36945  14.17653  2.34517   1.000 20.94687 ?  108 TRP B CE3 1 
ATOM   2674 C  CZ2 . TRP B 1 108 ? -8.17409  14.33533  1.95259   1.000 20.57606 ?  108 TRP B CZ2 1 
ATOM   2675 C  CZ3 . TRP B 1 108 ? -6.26184  13.60453  3.24510   1.000 17.91203 ?  108 TRP B CZ3 1 
ATOM   2676 C  CH2 . TRP B 1 108 ? -7.64776  13.68559  3.03914   1.000 22.24084 ?  108 TRP B CH2 1 
ATOM   2677 N  N   . GLN B 1 109 ? -1.30611  16.80087  1.27938   1.000 16.36342 ?  109 GLN B N   1 
ATOM   2678 C  CA  . GLN B 1 109 ? 0.13528   16.70254  1.45994   1.000 14.14007 ?  109 GLN B CA  1 
ATOM   2679 C  C   . GLN B 1 109 ? 0.45601   15.29031  1.93603   1.000 13.35216 ?  109 GLN B C   1 
ATOM   2680 O  O   . GLN B 1 109 ? -0.29427  14.73025  2.74223   1.000 14.16349 ?  109 GLN B O   1 
ATOM   2681 C  CB  . GLN B 1 109 ? 0.63508   17.74518  2.47313   1.000 15.56235 ?  109 GLN B CB  1 
ATOM   2682 C  CG  . GLN B 1 109 ? 2.15684   17.74738  2.68685   1.000 13.90934 ?  109 GLN B CG  1 
ATOM   2683 C  CD  . GLN B 1 109 ? 2.58323   16.81244  3.79466   1.000 15.04795 ?  109 GLN B CD  1 
ATOM   2684 O  OE1 . GLN B 1 109 ? 1.88745   16.68646  4.80169   1.000 16.01957 ?  109 GLN B OE1 1 
ATOM   2685 N  NE2 . GLN B 1 109 ? 3.72132   16.13923  3.61266   1.000 14.10629 ?  109 GLN B NE2 1 
ATOM   2686 N  N   . ILE B 1 110 ? 1.55883   14.70571  1.44634   1.000 14.91513 ?  110 ILE B N   1 
ATOM   2687 C  CA  . ILE B 1 110 ? 1.93862   13.36094  1.87083   1.000 14.57586 ?  110 ILE B CA  1 
ATOM   2688 C  C   . ILE B 1 110 ? 3.39070   13.30780  2.33923   1.000 14.47051 ?  110 ILE B C   1 
ATOM   2689 O  O   . ILE B 1 110 ? 4.27064   14.00228  1.81500   1.000 14.92613 ?  110 ILE B O   1 
ATOM   2690 C  CB  . ILE B 1 110 ? 1.68842   12.29050  0.77774   1.000 11.48173 ?  110 ILE B CB  1 
ATOM   2691 C  CG1 . ILE B 1 110 ? 2.33220   12.66549  -0.54952  1.000 14.40640 ?  110 ILE B CG1 1 
ATOM   2692 C  CG2 . ILE B 1 110 ? 0.19920   12.05318  0.62521   1.000 15.61032 ?  110 ILE B CG2 1 
ATOM   2693 C  CD1 . ILE B 1 110 ? 2.36612   11.48733  -1.56637  1.000 13.26740 ?  110 ILE B CD1 1 
ATOM   2694 N  N   . ASN B 1 111 ? 3.62464   12.46314  3.33658   1.000 13.52424 ?  111 ASN B N   1 
ATOM   2695 C  CA  . ASN B 1 111 ? 4.95033   12.00859  3.70880   1.000 9.33893  ?  111 ASN B CA  1 
ATOM   2696 C  C   . ASN B 1 111 ? 5.16346   10.64020  3.09618   1.000 11.17856 ?  111 ASN B C   1 
ATOM   2697 O  O   . ASN B 1 111 ? 4.27822   9.78286   3.16101   1.000 14.89458 ?  111 ASN B O   1 
ATOM   2698 C  CB  . ASN B 1 111 ? 5.07420   11.89738  5.23078   1.000 10.76867 ?  111 ASN B CB  1 
ATOM   2699 C  CG  . ASN B 1 111 ? 5.08865   13.23470  5.90687   1.000 15.32508 ?  111 ASN B CG  1 
ATOM   2700 O  OD1 . ASN B 1 111 ? 5.21949   14.26473  5.24912   1.000 9.82435  ?  111 ASN B OD1 1 
ATOM   2701 N  ND2 . ASN B 1 111 ? 4.98161   13.23202  7.23682   1.000 14.35255 ?  111 ASN B ND2 1 
ATOM   2702 N  N   . VAL B 1 112 ? 6.34188   10.42952  2.52714   1.000 11.91867 ?  112 VAL B N   1 
ATOM   2703 C  CA  . VAL B 1 112 ? 6.68457   9.18069   1.85903   1.000 11.73574 ?  112 VAL B CA  1 
ATOM   2704 C  C   . VAL B 1 112 ? 7.94896   8.63563   2.50710   1.000 11.06598 ?  112 VAL B C   1 
ATOM   2705 O  O   . VAL B 1 112 ? 9.01041   9.26650   2.43976   1.000 11.40292 ?  112 VAL B O   1 
ATOM   2706 C  CB  . VAL B 1 112 ? 6.88010   9.38171   0.34360   1.000 11.11075 ?  112 VAL B CB  1 
ATOM   2707 C  CG1 . VAL B 1 112 ? 7.13109   8.03935   -0.35026  1.000 11.31967 ?  112 VAL B CG1 1 
ATOM   2708 C  CG2 . VAL B 1 112 ? 5.65700   10.07248  -0.25626  1.000 13.84192 ?  112 VAL B CG2 1 
ATOM   2709 N  N   . HIS B 1 113 ? 7.83105   7.46673   3.13010   1.000 11.40513 ?  113 HIS B N   1 
ATOM   2710 C  CA  . HIS B 1 113 ? 8.92512   6.80495   3.81567   1.000 12.35855 ?  113 HIS B CA  1 
ATOM   2711 C  C   . HIS B 1 113 ? 9.30768   5.57785   3.00548   1.000 13.41767 ?  113 HIS B C   1 
ATOM   2712 O  O   . HIS B 1 113 ? 8.50681   4.64770   2.85859   1.000 13.47279 ?  113 HIS B O   1 
ATOM   2713 C  CB  . HIS B 1 113 ? 8.52201   6.39935   5.23256   1.000 12.60520 ?  113 HIS B CB  1 
ATOM   2714 C  CG  . HIS B 1 113 ? 8.08549   7.54264   6.09884   1.000 12.31153 ?  113 HIS B CG  1 
ATOM   2715 N  ND1 . HIS B 1 113 ? 8.92858   8.17274   6.99086   1.000 12.11533 ?  113 HIS B ND1 1 
ATOM   2716 C  CD2 . HIS B 1 113 ? 6.87851   8.13898   6.24009   1.000 14.03682 ?  113 HIS B CD2 1 
ATOM   2717 C  CE1 . HIS B 1 113 ? 8.26922   9.12585   7.62113   1.000 17.36172 ?  113 HIS B CE1 1 
ATOM   2718 N  NE2 . HIS B 1 113 ? 7.02204   9.12982   7.18032   1.000 15.78542 ?  113 HIS B NE2 1 
ATOM   2719 N  N   . GLN B 1 114 ? 10.52167  5.56821   2.48587   1.000 11.87524 ?  114 GLN B N   1 
ATOM   2720 C  CA  . GLN B 1 114 ? 11.06537  4.37416   1.85693   1.000 11.86126 ?  114 GLN B CA  1 
ATOM   2721 C  C   . GLN B 1 114 ? 11.88223  3.63555   2.91119   1.000 16.59346 ?  114 GLN B C   1 
ATOM   2722 O  O   . GLN B 1 114 ? 12.97961  4.07764   3.26902   1.000 13.34734 ?  114 GLN B O   1 
ATOM   2723 C  CB  . GLN B 1 114 ? 11.92000  4.72262   0.64189   1.000 13.33342 ?  114 GLN B CB  1 
ATOM   2724 C  CG  . GLN B 1 114 ? 12.34111  3.47398   -0.12100  1.000 15.63870 ?  114 GLN B CG  1 
ATOM   2725 C  CD  . GLN B 1 114 ? 13.23364  3.76183   -1.31159  1.000 17.13042 ?  114 GLN B CD  1 
ATOM   2726 O  OE1 . GLN B 1 114 ? 13.54976  4.91660   -1.59740  1.000 13.71478 ?  114 GLN B OE1 1 
ATOM   2727 N  NE2 . GLN B 1 114 ? 13.64366  2.70430   -2.01619  1.000 14.70718 ?  114 GLN B NE2 1 
ATOM   2728 N  N   . ASN B 1 115 ? 11.35085  2.51021   3.40614   1.000 11.28396 ?  115 ASN B N   1 
ATOM   2729 C  CA  . ASN B 1 115 ? 11.90177  1.81356   4.56644   1.000 11.28974 ?  115 ASN B CA  1 
ATOM   2730 C  C   . ASN B 1 115 ? 12.35987  0.42559   4.15602   1.000 13.22009 ?  115 ASN B C   1 
ATOM   2731 O  O   . ASN B 1 115 ? 11.59576  -0.31622  3.53394   1.000 13.17557 ?  115 ASN B O   1 
ATOM   2732 C  CB  . ASN B 1 115 ? 10.86690  1.66295   5.69087   1.000 9.92322  ?  115 ASN B CB  1 
ATOM   2733 C  CG  . ASN B 1 115 ? 10.66746  2.92527   6.51150   1.000 14.91364 ?  115 ASN B CG  1 
ATOM   2734 O  OD1 . ASN B 1 115 ? 10.97802  4.04465   6.07967   1.000 12.01169 ?  115 ASN B OD1 1 
ATOM   2735 N  ND2 . ASN B 1 115 ? 10.12453  2.74647   7.71280   1.000 10.51541 ?  115 ASN B ND2 1 
ATOM   2736 N  N   . ARG B 1 116 ? 13.59446  0.07553   4.51668   1.000 10.75981 ?  116 ARG B N   1 
ATOM   2737 C  CA  . ARG B 1 116 ? 14.04017  -1.30977  4.60037   1.000 10.16243 ?  116 ARG B CA  1 
ATOM   2738 C  C   . ARG B 1 116 ? 14.27288  -1.65423  6.06201   1.000 10.49428 ?  116 ARG B C   1 
ATOM   2739 O  O   . ARG B 1 116 ? 14.95768  -0.91218  6.77439   1.000 12.74787 ?  116 ARG B O   1 
ATOM   2740 C  CB  . ARG B 1 116 ? 15.33792  -1.54817  3.81812   1.000 13.53029 ?  116 ARG B CB  1 
ATOM   2741 C  CG  . ARG B 1 116 ? 16.01223  -2.86070  4.16410   1.000 11.44959 ?  116 ARG B CG  1 
ATOM   2742 C  CD  . ARG B 1 116 ? 17.20089  -3.15588  3.24423   1.000 16.59455 ?  116 ARG B CD  1 
ATOM   2743 N  NE  . ARG B 1 116 ? 16.71683  -3.52736  1.92117   1.000 16.72496 ?  116 ARG B NE  1 
ATOM   2744 C  CZ  . ARG B 1 116 ? 17.48910  -3.77499  0.87278   1.000 18.27716 ?  116 ARG B CZ  1 
ATOM   2745 N  NH1 . ARG B 1 116 ? 18.80326  -3.67767  0.94411   1.000 19.30229 ?  116 ARG B NH1 1 
ATOM   2746 N  NH2 . ARG B 1 116 ? 16.92613  -4.14092  -0.27234  1.000 19.13808 ?  116 ARG B NH2 1 
ATOM   2747 N  N   . THR B 1 117 ? 13.71714  -2.77232  6.51061   1.000 9.37896  ?  117 THR B N   1 
ATOM   2748 C  CA  . THR B 1 117 ? 14.04475  -3.32832  7.82166   1.000 10.42520 ?  117 THR B CA  1 
ATOM   2749 C  C   . THR B 1 117 ? 14.70375  -4.68434  7.61155   1.000 8.98627  ?  117 THR B C   1 
ATOM   2750 O  O   . THR B 1 117 ? 14.19398  -5.51934  6.85536   1.000 11.95089 ?  117 THR B O   1 
ATOM   2751 C  CB  . THR B 1 117 ? 12.80067  -3.46554  8.71918   1.000 10.97165 ?  117 THR B CB  1 
ATOM   2752 O  OG1 . THR B 1 117 ? 12.43781  -2.19049  9.27073   1.000 11.25263 ?  117 THR B OG1 1 
ATOM   2753 C  CG2 . THR B 1 117 ? 13.04943  -4.43033  9.86361   1.000 7.60128  ?  117 THR B CG2 1 
ATOM   2754 N  N   . ARG B 1 118 ? 15.81762  -4.90762  8.28851   1.000 9.14275  ?  118 ARG B N   1 
ATOM   2755 C  CA  . ARG B 1 118 ? 16.55406  -6.16055  8.18253   1.000 12.67839 ?  118 ARG B CA  1 
ATOM   2756 C  C   . ARG B 1 118 ? 16.33771  -7.03044  9.41063   1.000 13.39430 ?  118 ARG B C   1 
ATOM   2757 O  O   . ARG B 1 118 ? 16.18132  -6.53075  10.52848  1.000 11.82310 ?  118 ARG B O   1 
ATOM   2758 C  CB  . ARG B 1 118 ? 18.05063  -5.89789  8.01655   1.000 14.64680 ?  118 ARG B CB  1 
ATOM   2759 C  CG  . ARG B 1 118 ? 18.41085  -5.18546  6.73077   1.000 16.44245 ?  118 ARG B CG  1 
ATOM   2760 C  CD  . ARG B 1 118 ? 19.92595  -5.21639  6.48428   1.000 28.44594 ?  118 ARG B CD  1 
ATOM   2761 N  NE  . ARG B 1 118 ? 20.16470  -5.53609  5.08190   1.000 38.19447 ?  118 ARG B NE  1 
ATOM   2762 C  CZ  . ARG B 1 118 ? 20.07094  -6.75660  4.57133   1.000 36.95438 ?  118 ARG B CZ  1 
ATOM   2763 N  NH1 . ARG B 1 118 ? 19.88238  -7.81804  5.34613   1.000 35.39395 ?  118 ARG B NH1 1 
ATOM   2764 N  NH2 . ARG B 1 118 ? 20.16229  -6.91693  3.25207   1.000 40.29491 ?  118 ARG B NH2 1 
ATOM   2765 N  N   . ALA B 1 119 ? 16.36146  -8.33774  9.20576   1.000 13.47179 ?  119 ALA B N   1 
ATOM   2766 C  CA  . ALA B 1 119 ? 16.36743  -9.28005  10.30734  1.000 13.60231 ?  119 ALA B CA  1 
ATOM   2767 C  C   . ALA B 1 119 ? 17.52514  -10.24692 10.12365  1.000 18.81411 ?  119 ALA B C   1 
ATOM   2768 O  O   . ALA B 1 119 ? 18.03655  -10.43595 9.01608   1.000 18.97275 ?  119 ALA B O   1 
ATOM   2769 C  CB  . ALA B 1 119 ? 15.04594  -10.04749 10.40819  1.000 15.42297 ?  119 ALA B CB  1 
ATOM   2770 N  N   . ASP B 1 120 ? 17.95981  -10.82704 11.23486  1.000 15.95371 ?  120 ASP B N   1 
ATOM   2771 C  CA  . ASP B 1 120 ? 18.99072  -11.85102 11.20054  1.000 17.90985 ?  120 ASP B CA  1 
ATOM   2772 C  C   . ASP B 1 120 ? 18.70807  -12.85305 12.30658  1.000 18.27390 ?  120 ASP B C   1 
ATOM   2773 O  O   . ASP B 1 120 ? 17.81147  -12.65949 13.13384  1.000 17.88594 ?  120 ASP B O   1 
ATOM   2774 C  CB  . ASP B 1 120 ? 20.38572  -11.24889 11.33393  1.000 19.62538 ?  120 ASP B CB  1 
ATOM   2775 C  CG  . ASP B 1 120 ? 21.43268  -12.06330 10.60650  1.000 27.53378 ?  120 ASP B CG  1 
ATOM   2776 O  OD1 . ASP B 1 120 ? 21.17320  -13.25604 10.32973  1.000 21.84491 ?  120 ASP B OD1 1 
ATOM   2777 O  OD2 . ASP B 1 120 ? 22.51167  -11.51378 10.30894  1.000 25.90761 -1 120 ASP B OD2 1 
ATOM   2778 N  N   . GLY B 1 121 ? 19.48782  -13.93882 12.30531  1.000 18.63515 ?  121 GLY B N   1 
ATOM   2779 C  CA  . GLY B 1 121 ? 19.28251  -14.99921 13.27837  1.000 21.34718 ?  121 GLY B CA  1 
ATOM   2780 C  C   . GLY B 1 121 ? 19.10281  -14.49205 14.69690  1.000 26.04372 ?  121 GLY B C   1 
ATOM   2781 O  O   . GLY B 1 121 ? 18.11735  -14.80874 15.36711  1.000 37.08845 ?  121 GLY B O   1 
ATOM   2782 N  N   . GLY B 1 122 ? 20.03582  -13.67739 15.17785  1.000 14.48602 ?  122 GLY B N   1 
ATOM   2783 C  CA  . GLY B 1 122 ? 19.85866  -13.23025 16.56015  1.000 36.22549 ?  122 GLY B CA  1 
ATOM   2784 C  C   . GLY B 1 122 ? 18.83124  -12.12351 16.75906  1.000 27.53988 ?  122 GLY B C   1 
ATOM   2785 O  O   . GLY B 1 122 ? 18.37433  -11.88655 17.88733  1.000 22.16419 ?  122 GLY B O   1 
ATOM   2786 N  N   . ARG B 1 123 ? 18.43658  -11.47033 15.69471  1.000 17.59538 ?  123 ARG B N   1 
ATOM   2787 C  CA  . ARG B 1 123 ? 17.98208  -10.10487 15.85005  1.000 14.73567 ?  123 ARG B CA  1 
ATOM   2788 C  C   . ARG B 1 123 ? 16.78814  -9.83604  14.94766  1.000 11.02312 ?  123 ARG B C   1 
ATOM   2789 O  O   . ARG B 1 123 ? 16.94779  -9.59053  13.74942  1.000 15.36281 ?  123 ARG B O   1 
ATOM   2790 C  CB  . ARG B 1 123 ? 19.14536  -9.16728  15.53856  1.000 15.18894 ?  123 ARG B CB  1 
ATOM   2791 C  CG  . ARG B 1 123 ? 18.87595  -7.71634  15.83727  1.000 21.25596 ?  123 ARG B CG  1 
ATOM   2792 C  CD  . ARG B 1 123 ? 19.08958  -7.35578  17.30120  1.000 18.24896 ?  123 ARG B CD  1 
ATOM   2793 N  NE  . ARG B 1 123 ? 18.77084  -5.94731  17.48392  1.000 19.92567 ?  123 ARG B NE  1 
ATOM   2794 C  CZ  . ARG B 1 123 ? 19.56465  -4.94985  17.12190  1.000 16.59192 ?  123 ARG B CZ  1 
ATOM   2795 N  NH1 . ARG B 1 123 ? 20.78967  -5.16760  16.67536  1.000 18.61039 ?  123 ARG B NH1 1 
ATOM   2796 N  NH2 . ARG B 1 123 ? 19.10887  -3.70005  17.19326  1.000 14.98869 ?  123 ARG B NH2 1 
ATOM   2797 N  N   . PRO B 1 124 ? 15.58006  -9.86697  15.48375  1.000 13.26131 ?  124 PRO B N   1 
ATOM   2798 C  CA  . PRO B 1 124 ? 14.42561  -9.46540  14.68112  1.000 17.80829 ?  124 PRO B CA  1 
ATOM   2799 C  C   . PRO B 1 124 ? 14.54455  -8.00577  14.25710  1.000 15.38466 ?  124 PRO B C   1 
ATOM   2800 O  O   . PRO B 1 124 ? 15.29396  -7.21557  14.83314  1.000 13.07679 ?  124 PRO B O   1 
ATOM   2801 C  CB  . PRO B 1 124 ? 13.23382  -9.69204  15.61806  1.000 16.83503 ?  124 PRO B CB  1 
ATOM   2802 C  CG  . PRO B 1 124 ? 13.79188  -9.86352  16.97607  1.000 21.53670 ?  124 PRO B CG  1 
ATOM   2803 C  CD  . PRO B 1 124 ? 15.25119  -10.14645 16.89221  1.000 16.75211 ?  124 PRO B CD  1 
ATOM   2804 N  N   . GLY B 1 125 ? 13.80868  -7.65300  13.21510  1.000 11.88158 ?  125 GLY B N   1 
ATOM   2805 C  CA  . GLY B 1 125 ? 13.74920  -6.27655  12.79165  1.000 10.13761 ?  125 GLY B CA  1 
ATOM   2806 C  C   . GLY B 1 125 ? 12.45807  -5.61611  13.23492  1.000 14.15220 ?  125 GLY B C   1 
ATOM   2807 O  O   . GLY B 1 125 ? 11.37103  -5.92238  12.73249  1.000 11.82985 ?  125 GLY B O   1 
ATOM   2808 N  N   . PRO B 1 126 ? 12.55319  -4.68759  14.18764  1.000 13.11218 ?  126 PRO B N   1 
ATOM   2809 C  CA  . PRO B 1 126 ? 11.33539  -4.08041  14.74594  1.000 13.59963 ?  126 PRO B CA  1 
ATOM   2810 C  C   . PRO B 1 126 ? 10.69833  -3.13217  13.74524  1.000 10.51371 ?  126 PRO B C   1 
ATOM   2811 O  O   . PRO B 1 126 ? 11.36953  -2.27462  13.17143  1.000 11.77680 ?  126 PRO B O   1 
ATOM   2812 C  CB  . PRO B 1 126 ? 11.83955  -3.32936  15.99007  1.000 13.75681 ?  126 PRO B CB  1 
ATOM   2813 C  CG  . PRO B 1 126 ? 13.19845  -3.92500  16.27766  1.000 15.87378 ?  126 PRO B CG  1 
ATOM   2814 C  CD  . PRO B 1 126 ? 13.75715  -4.26060  14.91591  1.000 12.81152 ?  126 PRO B CD  1 
ATOM   2815 N  N   . LEU B 1 127 ? 9.38737   -3.27579  13.55991  1.000 10.39288 ?  127 LEU B N   1 
ATOM   2816 C  CA  . LEU B 1 127 ? 8.64691   -2.45773  12.60397  1.000 10.16499 ?  127 LEU B CA  1 
ATOM   2817 C  C   . LEU B 1 127 ? 7.89325   -1.31186  13.25973  1.000 14.66958 ?  127 LEU B C   1 
ATOM   2818 O  O   . LEU B 1 127 ? 7.79084   -0.22981  12.67553  1.000 16.07847 ?  127 LEU B O   1 
ATOM   2819 C  CB  . LEU B 1 127 ? 7.67367   -3.33602  11.81863  1.000 12.26241 ?  127 LEU B CB  1 
ATOM   2820 C  CG  . LEU B 1 127 ? 8.42453   -4.29476  10.88746  1.000 13.59045 ?  127 LEU B CG  1 
ATOM   2821 C  CD1 . LEU B 1 127 ? 7.45886   -5.23903  10.18814  1.000 13.26752 ?  127 LEU B CD1 1 
ATOM   2822 C  CD2 . LEU B 1 127 ? 9.25175   -3.49274  9.87082   1.000 15.35237 ?  127 LEU B CD2 1 
ATOM   2823 N  N   . THR B 1 128 ? 7.36668   -1.51100  14.46452  1.000 13.01347 ?  128 THR B N   1 
ATOM   2824 C  CA  . THR B 1 128 ? 6.66765   -0.45766  15.19633  1.000 12.20206 ?  128 THR B CA  1 
ATOM   2825 C  C   . THR B 1 128 ? 7.09813   -0.51298  16.65469  1.000 10.85219 ?  128 THR B C   1 
ATOM   2826 O  O   . THR B 1 128 ? 6.31848   -0.89259  17.53380  1.000 11.69023 ?  128 THR B O   1 
ATOM   2827 C  CB  . THR B 1 128 ? 5.14206   -0.58497  15.05735  1.000 13.10340 ?  128 THR B CB  1 
ATOM   2828 O  OG1 . THR B 1 128 ? 4.71001   -1.86805  15.51343  1.000 13.09090 ?  128 THR B OG1 1 
ATOM   2829 C  CG2 . THR B 1 128 ? 4.69479   -0.44478  13.61496  1.000 12.84169 ?  128 THR B CG2 1 
ATOM   2830 N  N   . PRO B 1 129 ? 8.34777   -0.14171  16.95121  1.000 13.87590 ?  129 PRO B N   1 
ATOM   2831 C  CA  . PRO B 1 129 ? 8.77793   -0.11812  18.35657  1.000 14.48869 ?  129 PRO B CA  1 
ATOM   2832 C  C   . PRO B 1 129 ? 7.97161   0.84580   19.19117  1.000 12.91067 ?  129 PRO B C   1 
ATOM   2833 O  O   . PRO B 1 129 ? 7.88474   0.67382   20.40612  1.000 21.22784 ?  129 PRO B O   1 
ATOM   2834 C  CB  . PRO B 1 129 ? 10.25386  0.29783   18.27324  1.000 16.97512 ?  129 PRO B CB  1 
ATOM   2835 C  CG  . PRO B 1 129 ? 10.40992  0.94950   16.94777  1.000 17.35904 ?  129 PRO B CG  1 
ATOM   2836 C  CD  . PRO B 1 129 ? 9.43802   0.25143   16.03790  1.000 15.38039 ?  129 PRO B CD  1 
ATOM   2837 N  N   . GLU B 1 130 ? 7.33656   1.83001   18.57072  1.000 15.86857 ?  130 GLU B N   1 
ATOM   2838 C  CA  . GLU B 1 130 ? 6.40784   2.68388   19.29215  1.000 19.15399 ?  130 GLU B CA  1 
ATOM   2839 C  C   . GLU B 1 130 ? 5.16903   1.92083   19.77024  1.000 17.74436 ?  130 GLU B C   1 
ATOM   2840 O  O   . GLU B 1 130 ? 4.41856   2.43467   20.60631  1.000 18.68672 ?  130 GLU B O   1 
ATOM   2841 C  CB  . GLU B 1 130 ? 6.01199   3.86716   18.39355  1.000 21.88478 ?  130 GLU B CB  1 
ATOM   2842 C  CG  . GLU B 1 130 ? 5.21739   3.51876   17.10973  1.000 17.62604 ?  130 GLU B CG  1 
ATOM   2843 C  CD  . GLU B 1 130 ? 6.09581   3.21742   15.88787  1.000 20.53474 ?  130 GLU B CD  1 
ATOM   2844 O  OE1 . GLU B 1 130 ? 7.21634   2.68358   16.04209  1.000 17.04782 ?  130 GLU B OE1 1 
ATOM   2845 O  OE2 . GLU B 1 130 ? 5.66653   3.51548   14.75864  1.000 32.76380 -1 130 GLU B OE2 1 
ATOM   2846 N  N   . GLY B 1 131 ? 4.93827   0.71018   19.27887  1.000 12.82742 ?  131 GLY B N   1 
ATOM   2847 C  CA  . GLY B 1 131 ? 3.76290   -0.05334  19.69060  1.000 12.59720 ?  131 GLY B CA  1 
ATOM   2848 C  C   . GLY B 1 131 ? 2.50507   0.35340   18.93198  1.000 12.23981 ?  131 GLY B C   1 
ATOM   2849 O  O   . GLY B 1 131 ? 2.55436   0.98776   17.86554  1.000 13.16892 ?  131 GLY B O   1 
ATOM   2850 N  N   . VAL B 1 132 ? 1.35397   -0.04238  19.48700  1.000 11.26886 ?  132 VAL B N   1 
ATOM   2851 C  CA  . VAL B 1 132 ? 0.07044   0.30334   18.88046  1.000 10.89696 ?  132 VAL B CA  1 
ATOM   2852 C  C   . VAL B 1 132 ? -0.10068  1.81273   18.91985  1.000 12.90418 ?  132 VAL B C   1 
ATOM   2853 O  O   . VAL B 1 132 ? 0.08362   2.43714   19.96886  1.000 12.48145 ?  132 VAL B O   1 
ATOM   2854 C  CB  . VAL B 1 132 ? -1.07882  -0.39451  19.62499  1.000 13.88367 ?  132 VAL B CB  1 
ATOM   2855 C  CG1 . VAL B 1 132 ? -2.43174  0.04241   19.06412  1.000 11.33403 ?  132 VAL B CG1 1 
ATOM   2856 C  CG2 . VAL B 1 132 ? -0.92653  -1.89810  19.58164  1.000 11.69343 ?  132 VAL B CG2 1 
ATOM   2857 N  N   . HIS B 1 133 ? -0.47703  2.40989   17.79213  1.000 7.91103  ?  133 HIS B N   1 
ATOM   2858 C  CA  . HIS B 1 133 ? -0.38491  3.86304   17.68243  1.000 12.43065 ?  133 HIS B CA  1 
ATOM   2859 C  C   . HIS B 1 133 ? -1.14786  4.32548   16.44935  1.000 18.35314 ?  133 HIS B C   1 
ATOM   2860 O  O   . HIS B 1 133 ? -1.39858  3.54956   15.51912  1.000 13.86502 ?  133 HIS B O   1 
ATOM   2861 C  CB  . HIS B 1 133 ? 1.07256   4.30250   17.54707  1.000 12.19453 ?  133 HIS B CB  1 
ATOM   2862 C  CG  . HIS B 1 133 ? 1.63049   3.97916   16.19965  1.000 15.10326 ?  133 HIS B CG  1 
ATOM   2863 N  ND1 . HIS B 1 133 ? 1.99102   2.69667   15.83563  1.000 13.71892 ?  133 HIS B ND1 1 
ATOM   2864 C  CD2 . HIS B 1 133 ? 1.79371   4.74471   15.09363  1.000 14.08177 ?  133 HIS B CD2 1 
ATOM   2865 C  CE1 . HIS B 1 133 ? 2.39425   2.69646   14.57679  1.000 12.91049 ?  133 HIS B CE1 1 
ATOM   2866 N  NE2 . HIS B 1 133 ? 2.28647   3.92860   14.10426  1.000 17.16259 ?  133 HIS B NE2 1 
ATOM   2867 N  N   . HIS B 1 134 ? -1.48561  5.61800   16.45167  1.000 14.26959 ?  134 HIS B N   1 
ATOM   2868 C  CA  . HIS B 1 134 ? -1.88254  6.36853   15.26780  1.000 14.27412 ?  134 HIS B CA  1 
ATOM   2869 C  C   . HIS B 1 134 ? -0.67945  7.14325   14.74401  1.000 15.29771 ?  134 HIS B C   1 
ATOM   2870 O  O   . HIS B 1 134 ? 0.11181   7.67052   15.52811  1.000 14.65824 ?  134 HIS B O   1 
ATOM   2871 C  CB  . HIS B 1 134 ? -3.00852  7.35519   15.59164  1.000 14.82172 ?  134 HIS B CB  1 
ATOM   2872 C  CG  . HIS B 1 134 ? -4.18401  6.72935   16.27333  1.000 19.45307 ?  134 HIS B CG  1 
ATOM   2873 N  ND1 . HIS B 1 134 ? -5.26363  6.22784   15.57934  1.000 14.84343 ?  134 HIS B ND1 1 
ATOM   2874 C  CD2 . HIS B 1 134 ? -4.45098  6.52369   17.58658  1.000 22.20133 ?  134 HIS B CD2 1 
ATOM   2875 C  CE1 . HIS B 1 134 ? -6.14178  5.73039   16.43528  1.000 16.50806 ?  134 HIS B CE1 1 
ATOM   2876 N  NE2 . HIS B 1 134 ? -5.67399  5.89732   17.65890  1.000 16.39908 ?  134 HIS B NE2 1 
ATOM   2877 N  N   . ASP B 1 135 ? -0.54228  7.23318   13.41935  1.000 13.74102 ?  135 ASP B N   1 
ATOM   2878 C  CA  . ASP B 1 135 ? 0.54490   8.06449   12.91443  1.000 11.52757 ?  135 ASP B CA  1 
ATOM   2879 C  C   . ASP B 1 135 ? 0.23501   9.53937   13.04587  1.000 11.26510 ?  135 ASP B C   1 
ATOM   2880 O  O   . ASP B 1 135 ? 1.15072   10.35635  12.94882  1.000 12.51744 ?  135 ASP B O   1 
ATOM   2881 C  CB  . ASP B 1 135 ? 0.86248   7.73606   11.46328  1.000 11.98953 ?  135 ASP B CB  1 
ATOM   2882 C  CG  . ASP B 1 135 ? 1.53158   6.38059   11.31173  1.000 18.61262 ?  135 ASP B CG  1 
ATOM   2883 O  OD1 . ASP B 1 135 ? 2.18439   5.92176   12.27655  1.000 16.24738 ?  135 ASP B OD1 1 
ATOM   2884 O  OD2 . ASP B 1 135 ? 1.42251   5.78819   10.22339  1.000 17.37423 -1 135 ASP B OD2 1 
ATOM   2885 N  N   . GLY B 1 136 ? -1.02605  9.89600   13.25067  1.000 13.78094 ?  136 GLY B N   1 
ATOM   2886 C  CA  . GLY B 1 136 ? -1.40685  11.28201  13.38969  1.000 17.56915 ?  136 GLY B CA  1 
ATOM   2887 C  C   . GLY B 1 136 ? -1.98591  11.90856  12.13658  1.000 17.37219 ?  136 GLY B C   1 
ATOM   2888 O  O   . GLY B 1 136 ? -2.34117  13.09534  12.16611  1.000 14.95816 ?  136 GLY B O   1 
ATOM   2889 N  N   . HIS B 1 137 ? -2.10546  11.15469  11.04332  1.000 11.97952 ?  137 HIS B N   1 
ATOM   2890 C  CA  . HIS B 1 137 ? -2.64286  11.68975  9.80521   1.000 15.56203 ?  137 HIS B CA  1 
ATOM   2891 C  C   . HIS B 1 137 ? -4.08482  11.21429  9.60875   1.000 17.74338 ?  137 HIS B C   1 
ATOM   2892 O  O   . HIS B 1 137 ? -4.66836  10.52845  10.45506  1.000 16.52988 ?  137 HIS B O   1 
ATOM   2893 C  CB  . HIS B 1 137 ? -1.74945  11.30316  8.62216   1.000 14.33038 ?  137 HIS B CB  1 
ATOM   2894 C  CG  . HIS B 1 137 ? -0.30738  11.70119  8.78794   1.000 15.58068 ?  137 HIS B CG  1 
ATOM   2895 N  ND1 . HIS B 1 137 ? 0.29511   12.66553  8.00894   1.000 15.63444 ?  137 HIS B ND1 1 
ATOM   2896 C  CD2 . HIS B 1 137 ? 0.65474   11.24548  9.62765   1.000 18.34081 ?  137 HIS B CD2 1 
ATOM   2897 C  CE1 . HIS B 1 137 ? 1.56219   12.79153  8.36298   1.000 18.02594 ?  137 HIS B CE1 1 
ATOM   2898 N  NE2 . HIS B 1 137 ? 1.80769   11.93711  9.33894   1.000 15.02166 ?  137 HIS B NE2 1 
ATOM   2899 N  N   . GLU B 1 138 ? -4.66576  11.59848  8.46764   1.000 14.11700 ?  138 GLU B N   1 
ATOM   2900 C  CA  . GLU B 1 138 ? -6.01874  11.16537  8.13762   1.000 17.95652 ?  138 GLU B CA  1 
ATOM   2901 C  C   . GLU B 1 138 ? -6.02215  9.75696   7.55251   1.000 14.35627 ?  138 GLU B C   1 
ATOM   2902 O  O   . GLU B 1 138 ? -6.81947  8.90397   7.96229   1.000 14.15349 ?  138 GLU B O   1 
ATOM   2903 C  CB  . GLU B 1 138 ? -6.66921  12.14228  7.15838   1.000 14.83705 ?  138 GLU B CB  1 
ATOM   2904 C  CG  . GLU B 1 138 ? -8.18347  12.08710  7.18749   1.000 20.75004 ?  138 GLU B CG  1 
ATOM   2905 C  CD  . GLU B 1 138 ? -8.86624  13.24744  6.45852   1.000 22.06742 ?  138 GLU B CD  1 
ATOM   2906 O  OE1 . GLU B 1 138 ? -8.24726  14.31468  6.23964   1.000 22.43080 ?  138 GLU B OE1 1 
ATOM   2907 O  OE2 . GLU B 1 138 ? -10.04261 13.07683  6.10923   1.000 21.85097 -1 138 GLU B OE2 1 
ATOM   2908 N  N   . PHE B 1 139 ? -5.14678  9.49835   6.59242   1.000 11.51093 ?  139 PHE B N   1 
ATOM   2909 C  CA  . PHE B 1 139 ? -5.04854  8.19138   5.97525   1.000 13.63594 ?  139 PHE B CA  1 
ATOM   2910 C  C   . PHE B 1 139 ? -3.59055  7.77598   5.90754   1.000 14.11183 ?  139 PHE B C   1 
ATOM   2911 O  O   . PHE B 1 139 ? -2.69089  8.61215   5.80718   1.000 14.23259 ?  139 PHE B O   1 
ATOM   2912 C  CB  . PHE B 1 139 ? -5.63461  8.17305   4.56202   1.000 14.87684 ?  139 PHE B CB  1 
ATOM   2913 C  CG  . PHE B 1 139 ? -7.09656  8.54117   4.49625   1.000 20.10837 ?  139 PHE B CG  1 
ATOM   2914 C  CD1 . PHE B 1 139 ? -8.06903  7.70101   5.02980   1.000 18.40920 ?  139 PHE B CD1 1 
ATOM   2915 C  CD2 . PHE B 1 139 ? -7.49721  9.72246   3.87363   1.000 18.95948 ?  139 PHE B CD2 1 
ATOM   2916 C  CE1 . PHE B 1 139 ? -9.43208  8.04102   4.95018   1.000 19.36577 ?  139 PHE B CE1 1 
ATOM   2917 C  CE2 . PHE B 1 139 ? -8.85202  10.06850  3.78585   1.000 17.39509 ?  139 PHE B CE2 1 
ATOM   2918 C  CZ  . PHE B 1 139 ? -9.81395  9.22942   4.32415   1.000 19.95515 ?  139 PHE B CZ  1 
ATOM   2919 N  N   . VAL B 1 140 ? -3.36911  6.46657   5.91438   1.000 11.14546 ?  140 VAL B N   1 
ATOM   2920 C  CA  . VAL B 1 140 ? -2.02762  5.90557   5.82901   1.000 10.06966 ?  140 VAL B CA  1 
ATOM   2921 C  C   . VAL B 1 140 ? -2.06577  4.75297   4.82871   1.000 11.50547 ?  140 VAL B C   1 
ATOM   2922 O  O   . VAL B 1 140 ? -3.02993  3.98216   4.79866   1.000 12.56210 ?  140 VAL B O   1 
ATOM   2923 C  CB  . VAL B 1 140 ? -1.52621  5.44546   7.21077   1.000 10.71611 ?  140 VAL B CB  1 
ATOM   2924 C  CG1 . VAL B 1 140 ? -0.35414  4.48499   7.07312   1.000 12.28021 ?  140 VAL B CG1 1 
ATOM   2925 C  CG2 . VAL B 1 140 ? -1.14567  6.65920   8.05474   1.000 9.15843  ?  140 VAL B CG2 1 
ATOM   2926 N  N   . MET B 1 141 ? -1.04114  4.66325   3.98784   1.000 11.73093 ?  141 MET B N   1 
ATOM   2927 C  CA  . MET B 1 141 ? -0.89573  3.59106   3.02246   1.000 13.17890 ?  141 MET B CA  1 
ATOM   2928 C  C   . MET B 1 141 ? 0.44352   2.93728   3.27652   1.000 17.27645 ?  141 MET B C   1 
ATOM   2929 O  O   . MET B 1 141 ? 1.46750   3.62637   3.34424   1.000 16.89173 ?  141 MET B O   1 
ATOM   2930 C  CB  . MET B 1 141 ? -0.96121  4.10482   1.57926   1.000 12.57056 ?  141 MET B CB  1 
ATOM   2931 C  CG  . MET B 1 141 ? -0.63781  3.01670   0.55174   1.000 14.95227 ?  141 MET B CG  1 
ATOM   2932 S  SD  . MET B 1 141 ? -0.66136  3.58756   -1.15975  1.000 16.58427 ?  141 MET B SD  1 
ATOM   2933 C  CE  . MET B 1 141 ? -0.31529  2.07551   -2.04370  1.000 15.36011 ?  141 MET B CE  1 
ATOM   2934 N  N   . ILE B 1 142 ? 0.43720   1.61955   3.44682   1.000 13.78426 ?  142 ILE B N   1 
ATOM   2935 C  CA  . ILE B 1 142 ? 1.66312   0.87967   3.69251   1.000 12.75809 ?  142 ILE B CA  1 
ATOM   2936 C  C   . ILE B 1 142 ? 1.76222   -0.19502  2.63373   1.000 13.88414 ?  142 ILE B C   1 
ATOM   2937 O  O   . ILE B 1 142 ? 0.90575   -1.08576  2.56339   1.000 15.17741 ?  142 ILE B O   1 
ATOM   2938 C  CB  . ILE B 1 142 ? 1.70683   0.26812   5.08743   1.000 15.75287 ?  142 ILE B CB  1 
ATOM   2939 C  CG1 . ILE B 1 142 ? 1.71813   1.38478   6.13129   1.000 12.43894 ?  142 ILE B CG1 1 
ATOM   2940 C  CG2 . ILE B 1 142 ? 2.93748   -0.65120  5.19896   1.000 14.10860 ?  142 ILE B CG2 1 
ATOM   2941 C  CD1 . ILE B 1 142 ? 1.34196   0.92566   7.50272   1.000 12.72599 ?  142 ILE B CD1 1 
ATOM   2942 N  N   . ALA B 1 143 ? 2.79765   -0.12227  1.81389   1.000 13.17975 ?  143 ALA B N   1 
ATOM   2943 C  CA  . ALA B 1 143 ? 2.91944   -0.99589  0.65852   1.000 14.72962 ?  143 ALA B CA  1 
ATOM   2944 C  C   . ALA B 1 143 ? 4.16891   -1.84151  0.80276   1.000 10.74245 ?  143 ALA B C   1 
ATOM   2945 O  O   . ALA B 1 143 ? 5.22037   -1.32476  1.18297   1.000 10.90720 ?  143 ALA B O   1 
ATOM   2946 C  CB  . ALA B 1 143 ? 2.97725   -0.17466  -0.63178  1.000 13.39854 ?  143 ALA B CB  1 
ATOM   2947 N  N   . ILE B 1 144 ? 4.05917   -3.13181  0.49153   1.000 12.68581 ?  144 ILE B N   1 
ATOM   2948 C  CA  . ILE B 1 144 ? 5.18618   -4.05899  0.57074   1.000 12.42127 ?  144 ILE B CA  1 
ATOM   2949 C  C   . ILE B 1 144 ? 5.75960   -4.21893  -0.82763  1.000 13.47779 ?  144 ILE B C   1 
ATOM   2950 O  O   . ILE B 1 144 ? 5.05564   -4.64401  -1.74953  1.000 13.94102 ?  144 ILE B O   1 
ATOM   2951 C  CB  . ILE B 1 144 ? 4.76281   -5.42551  1.13745   1.000 11.55123 ?  144 ILE B CB  1 
ATOM   2952 C  CG1 . ILE B 1 144 ? 3.84608   -5.26472  2.34316   1.000 10.42021 ?  144 ILE B CG1 1 
ATOM   2953 C  CG2 . ILE B 1 144 ? 5.98184   -6.28503  1.43558   1.000 12.73891 ?  144 ILE B CG2 1 
ATOM   2954 C  CD1 . ILE B 1 144 ? 4.38200   -4.43263  3.46355   1.000 13.90918 ?  144 ILE B CD1 1 
ATOM   2955 N  N   . LEU B 1 145 ? 7.03753   -3.89962  -0.99982  1.000 14.79197 ?  145 LEU B N   1 
ATOM   2956 C  CA  . LEU B 1 145 ? 7.64229   -4.01469  -2.31956  1.000 15.32910 ?  145 LEU B CA  1 
ATOM   2957 C  C   . LEU B 1 145 ? 8.54091   -5.22281  -2.46598  1.000 17.84792 ?  145 LEU B C   1 
ATOM   2958 O  O   . LEU B 1 145 ? 8.77600   -5.66566  -3.59725  1.000 18.68711 ?  145 LEU B O   1 
ATOM   2959 C  CB  . LEU B 1 145 ? 8.43107   -2.75169  -2.66033  1.000 15.45802 ?  145 LEU B CB  1 
ATOM   2960 C  CG  . LEU B 1 145 ? 7.33989   -1.77629  -3.09963  1.000 24.71901 ?  145 LEU B CG  1 
ATOM   2961 C  CD1 . LEU B 1 145 ? 6.95914   -0.81791  -1.98567  1.000 12.28530 ?  145 LEU B CD1 1 
ATOM   2962 C  CD2 . LEU B 1 145 ? 7.67199   -1.07419  -4.39852  1.000 25.73407 ?  145 LEU B CD2 1 
ATOM   2963 N  N   . ASN B 1 146 ? 9.04758   -5.75855  -1.36100  1.000 15.71717 ?  146 ASN B N   1 
ATOM   2964 C  CA  . ASN B 1 146 ? 9.87409   -6.94836  -1.44748  1.000 15.24996 ?  146 ASN B CA  1 
ATOM   2965 C  C   . ASN B 1 146 ? 10.07241  -7.51905  -0.05530  1.000 16.73659 ?  146 ASN B C   1 
ATOM   2966 O  O   . ASN B 1 146 ? 10.24708  -6.76716  0.91125   1.000 11.93868 ?  146 ASN B O   1 
ATOM   2967 C  CB  . ASN B 1 146 ? 11.23653  -6.64353  -2.08298  1.000 16.59630 ?  146 ASN B CB  1 
ATOM   2968 C  CG  . ASN B 1 146 ? 11.93220  -7.90763  -2.58638  1.000 24.74155 ?  146 ASN B CG  1 
ATOM   2969 O  OD1 . ASN B 1 146 ? 11.31157  -8.96984  -2.68019  1.000 23.11155 ?  146 ASN B OD1 1 
ATOM   2970 N  ND2 . ASN B 1 146 ? 13.21009  -7.79382  -2.91924  1.000 24.56415 ?  146 ASN B ND2 1 
ATOM   2971 N  N   . LYS B 1 147 ? 10.06388  -8.84475  0.03562   1.000 13.57551 ?  147 LYS B N   1 
ATOM   2972 C  CA  . LYS B 1 147 ? 10.39773  -9.54802  1.27066   1.000 15.17298 ?  147 LYS B CA  1 
ATOM   2973 C  C   . LYS B 1 147 ? 11.33455  -10.66929 0.88030   1.000 19.00091 ?  147 LYS B C   1 
ATOM   2974 O  O   . LYS B 1 147 ? 11.05208  -11.40453 -0.06607  1.000 15.39912 ?  147 LYS B O   1 
ATOM   2975 C  CB  . LYS B 1 147 ? 9.15835   -10.10396 1.99917   1.000 13.96717 ?  147 LYS B CB  1 
ATOM   2976 C  CG  . LYS B 1 147 ? 8.31502   -9.03097  2.69211   1.000 16.24724 ?  147 LYS B CG  1 
ATOM   2977 C  CD  . LYS B 1 147 ? 6.98985   -9.57202  3.19783   1.000 14.76791 ?  147 LYS B CD  1 
ATOM   2978 C  CE  . LYS B 1 147 ? 7.15404   -10.49054 4.39098   1.000 12.54497 ?  147 LYS B CE  1 
ATOM   2979 N  NZ  . LYS B 1 147 ? 5.80705   -10.95103 4.87886   1.000 12.37130 ?  147 LYS B NZ  1 
ATOM   2980 N  N   . VAL B 1 148 ? 12.47106  -10.75970 1.56171   1.000 16.88170 ?  148 VAL B N   1 
ATOM   2981 C  CA  . VAL B 1 148 ? 13.46947  -11.77727 1.27810   1.000 20.87265 ?  148 VAL B CA  1 
ATOM   2982 C  C   . VAL B 1 148 ? 13.80832  -12.47296 2.59232   1.000 22.78124 ?  148 VAL B C   1 
ATOM   2983 O  O   . VAL B 1 148 ? 14.32339  -11.83555 3.51653   1.000 17.41946 ?  148 VAL B O   1 
ATOM   2984 C  CB  . VAL B 1 148 ? 14.72291  -11.17373 0.63934   1.000 20.49066 ?  148 VAL B CB  1 
ATOM   2985 C  CG1 . VAL B 1 148 ? 15.79244  -12.24363 0.50800   1.000 25.75129 ?  148 VAL B CG1 1 
ATOM   2986 C  CG2 . VAL B 1 148 ? 14.37771  -10.56726 -0.72589  1.000 21.70289 ?  148 VAL B CG2 1 
ATOM   2987 N  N   . ASN B 1 149 ? 13.48832  -13.76466 2.68853   1.000 18.53474 ?  149 ASN B N   1 
ATOM   2988 C  CA  . ASN B 1 149 ? 13.92356  -14.61420 3.79925   1.000 16.83949 ?  149 ASN B CA  1 
ATOM   2989 C  C   . ASN B 1 149 ? 13.47037  -14.08535 5.15806   1.000 20.12890 ?  149 ASN B C   1 
ATOM   2990 O  O   . ASN B 1 149 ? 14.23462  -14.07950 6.12828   1.000 17.21985 ?  149 ASN B O   1 
ATOM   2991 C  CB  . ASN B 1 149 ? 15.43909  -14.78643 3.78681   1.000 17.30038 ?  149 ASN B CB  1 
ATOM   2992 C  CG  . ASN B 1 149 ? 15.89352  -15.93056 4.65851   1.000 22.50064 ?  149 ASN B CG  1 
ATOM   2993 O  OD1 . ASN B 1 149 ? 15.22965  -16.96508 4.74284   1.000 21.28609 ?  149 ASN B OD1 1 
ATOM   2994 N  ND2 . ASN B 1 149 ? 17.02086  -15.74501 5.33477   1.000 26.61813 ?  149 ASN B ND2 1 
ATOM   2995 N  N   . VAL B 1 150 ? 12.21947  -13.64675 5.24800   1.000 19.84076 ?  150 VAL B N   1 
ATOM   2996 C  CA  . VAL B 1 150 ? 11.69733  -13.14933 6.51339   1.000 17.71328 ?  150 VAL B CA  1 
ATOM   2997 C  C   . VAL B 1 150 ? 10.35991  -13.80037 6.81044   1.000 16.01556 ?  150 VAL B C   1 
ATOM   2998 O  O   . VAL B 1 150 ? 9.58842   -14.11418 5.90256   1.000 18.07915 ?  150 VAL B O   1 
ATOM   2999 C  CB  . VAL B 1 150 ? 11.56275  -11.61423 6.51069   1.000 17.32426 ?  150 VAL B CB  1 
ATOM   3000 C  CG1 . VAL B 1 150 ? 12.94054  -10.98364 6.42306   1.000 11.82463 ?  150 VAL B CG1 1 
ATOM   3001 C  CG2 . VAL B 1 150 ? 10.67385  -11.15297 5.33676   1.000 14.92715 ?  150 VAL B CG2 1 
ATOM   3002 N  N   . ALA B 1 151 ? 10.08513  -13.99596 8.09093   1.000 12.88396 ?  151 ALA B N   1 
ATOM   3003 C  CA  . ALA B 1 151 ? 8.75605   -14.33599 8.58205   1.000 18.56976 ?  151 ALA B CA  1 
ATOM   3004 C  C   . ALA B 1 151 ? 8.27846   -13.21181 9.50717   1.000 17.14269 ?  151 ALA B C   1 
ATOM   3005 O  O   . ALA B 1 151 ? 8.91738   -12.16720 9.62916   1.000 16.36676 ?  151 ALA B O   1 
ATOM   3006 C  CB  . ALA B 1 151 ? 8.76874   -15.69487 9.28860   1.000 21.19853 ?  151 ALA B CB  1 
ATOM   3007 N  N   . GLY B 1 152 ? 7.13423   -13.42048 10.14773  1.000 16.37165 ?  152 GLY B N   1 
ATOM   3008 C  CA  . GLY B 1 152 ? 6.61322   -12.36605 11.00405  1.000 15.76816 ?  152 GLY B CA  1 
ATOM   3009 C  C   . GLY B 1 152 ? 6.17333   -11.17024 10.18520  1.000 15.76483 ?  152 GLY B C   1 
ATOM   3010 O  O   . GLY B 1 152 ? 5.71143   -11.30186 9.04549   1.000 15.49238 ?  152 GLY B O   1 
ATOM   3011 N  N   . GLY B 1 153 ? 6.35508   -9.97733  10.75139  1.000 12.42643 ?  153 GLY B N   1 
ATOM   3012 C  CA  . GLY B 1 153 ? 5.91241   -8.78159  10.04926  1.000 14.10206 ?  153 GLY B CA  1 
ATOM   3013 C  C   . GLY B 1 153 ? 4.41277   -8.75205  9.81901   1.000 13.76015 ?  153 GLY B C   1 
ATOM   3014 O  O   . GLY B 1 153 ? 3.95262   -8.42145  8.71282   1.000 13.96527 ?  153 GLY B O   1 
ATOM   3015 N  N   . THR B 1 154 ? 3.63611   -9.08627  10.84053  1.000 10.41498 ?  154 THR B N   1 
ATOM   3016 C  CA  . THR B 1 154 ? 2.18554   -9.18247  10.71855  1.000 10.66048 ?  154 THR B CA  1 
ATOM   3017 C  C   . THR B 1 154 ? 1.55001   -7.86716  11.13959  1.000 12.39281 ?  154 THR B C   1 
ATOM   3018 O  O   . THR B 1 154 ? 1.73691   -7.41654  12.27553  1.000 10.97403 ?  154 THR B O   1 
ATOM   3019 C  CB  . THR B 1 154 ? 1.65987   -10.33990 11.56778  1.000 11.03831 ?  154 THR B CB  1 
ATOM   3020 O  OG1 . THR B 1 154 ? 2.30993   -11.53464 11.14141  1.000 14.43664 ?  154 THR B OG1 1 
ATOM   3021 C  CG2 . THR B 1 154 ? 0.16157   -10.50006 11.42713  1.000 10.77873 ?  154 THR B CG2 1 
ATOM   3022 N  N   . THR B 1 155 ? 0.81144   -7.25514  10.21905  1.000 13.83834 ?  155 THR B N   1 
ATOM   3023 C  CA  . THR B 1 155 ? 0.06821   -6.03542  10.51444  1.000 11.90890 ?  155 THR B CA  1 
ATOM   3024 C  C   . THR B 1 155 ? -1.14242  -6.35236  11.38150  1.000 15.79509 ?  155 THR B C   1 
ATOM   3025 O  O   . THR B 1 155 ? -1.90216  -7.28093  11.09503  1.000 12.61087 ?  155 THR B O   1 
ATOM   3026 C  CB  . THR B 1 155 ? -0.38385  -5.36771  9.21198   1.000 9.95445  ?  155 THR B CB  1 
ATOM   3027 O  OG1 . THR B 1 155 ? 0.76167   -4.94791  8.45962   1.000 11.82343 ?  155 THR B OG1 1 
ATOM   3028 C  CG2 . THR B 1 155 ? -1.24827  -4.14496  9.50709   1.000 11.54739 ?  155 THR B CG2 1 
ATOM   3029 N  N   . ARG B 1 156 ? -1.33048  -5.57686  12.44913  1.000 13.06831 ?  156 ARG B N   1 
ATOM   3030 C  CA  . ARG B 1 156 ? -2.48538  -5.75835  13.31838  1.000 13.47418 ?  156 ARG B CA  1 
ATOM   3031 C  C   . ARG B 1 156 ? -3.22741  -4.43916  13.46839  1.000 14.47555 ?  156 ARG B C   1 
ATOM   3032 O  O   . ARG B 1 156 ? -2.61168  -3.40778  13.76575  1.000 11.27299 ?  156 ARG B O   1 
ATOM   3033 C  CB  . ARG B 1 156 ? -2.06551  -6.30113  14.68409  1.000 17.60686 ?  156 ARG B CB  1 
ATOM   3034 C  CG  . ARG B 1 156 ? -1.49248  -7.72350  14.65357  1.000 17.71823 ?  156 ARG B CG  1 
ATOM   3035 C  CD  . ARG B 1 156 ? -0.10496  -7.77945  15.25142  1.000 24.62819 ?  156 ARG B CD  1 
ATOM   3036 N  NE  . ARG B 1 156 ? 0.08471   -7.05091  16.50855  1.000 12.85491 ?  156 ARG B NE  1 
ATOM   3037 C  CZ  . ARG B 1 156 ? 0.37997   -7.61924  17.67038  1.000 16.96545 ?  156 ARG B CZ  1 
ATOM   3038 N  NH1 . ARG B 1 156 ? 0.32556   -8.93243  17.83112  1.000 19.32163 ?  156 ARG B NH1 1 
ATOM   3039 N  NH2 . ARG B 1 156 ? 0.77539   -6.85402  18.68603  1.000 16.38560 ?  156 ARG B NH2 1 
ATOM   3040 N  N   . LEU B 1 157 ? -4.54668  -4.47705  13.27988  1.000 9.65784  ?  157 LEU B N   1 
ATOM   3041 C  CA  . LEU B 1 157 ? -5.37413  -3.27362  13.34063  1.000 12.98718 ?  157 LEU B CA  1 
ATOM   3042 C  C   . LEU B 1 157 ? -6.24047  -3.27901  14.59670  1.000 18.16790 ?  157 LEU B C   1 
ATOM   3043 O  O   . LEU B 1 157 ? -6.82603  -4.30340  14.95371  1.000 11.36068 ?  157 LEU B O   1 
ATOM   3044 C  CB  . LEU B 1 157 ? -6.24411  -3.15318  12.08775  1.000 10.03886 ?  157 LEU B CB  1 
ATOM   3045 C  CG  . LEU B 1 157 ? -5.41053  -3.10977  10.80070  1.000 12.39280 ?  157 LEU B CG  1 
ATOM   3046 C  CD1 . LEU B 1 157 ? -6.31276  -2.99061  9.55294   1.000 11.52758 ?  157 LEU B CD1 1 
ATOM   3047 C  CD2 . LEU B 1 157 ? -4.44698  -1.94146  10.87494  1.000 12.86694 ?  157 LEU B CD2 1 
ATOM   3048 N  N   . TRP B 1 158 ? -6.33679  -2.12412  15.25529  1.000 14.61797 ?  158 TRP B N   1 
ATOM   3049 C  CA  . TRP B 1 158 ? -6.91905  -2.04084  16.58809  1.000 14.13248 ?  158 TRP B CA  1 
ATOM   3050 C  C   . TRP B 1 158 ? -7.94821  -0.92720  16.69297  1.000 16.72624 ?  158 TRP B C   1 
ATOM   3051 O  O   . TRP B 1 158 ? -7.66791  0.22258   16.32887  1.000 17.29556 ?  158 TRP B O   1 
ATOM   3052 C  CB  . TRP B 1 158 ? -5.84241  -1.76971  17.62201  1.000 14.65533 ?  158 TRP B CB  1 
ATOM   3053 C  CG  . TRP B 1 158 ? -4.69261  -2.70390  17.64953  1.000 14.73044 ?  158 TRP B CG  1 
ATOM   3054 C  CD1 . TRP B 1 158 ? -3.73142  -2.86694  16.68879  1.000 12.96477 ?  158 TRP B CD1 1 
ATOM   3055 C  CD2 . TRP B 1 158 ? -4.32568  -3.55208  18.73512  1.000 15.03444 ?  158 TRP B CD2 1 
ATOM   3056 N  NE1 . TRP B 1 158 ? -2.79661  -3.78392  17.11059  1.000 13.87983 ?  158 TRP B NE1 1 
ATOM   3057 C  CE2 . TRP B 1 158 ? -3.13631  -4.21595  18.36444  1.000 12.77784 ?  158 TRP B CE2 1 
ATOM   3058 C  CE3 . TRP B 1 158 ? -4.88515  -3.81832  19.99192  1.000 14.47516 ?  158 TRP B CE3 1 
ATOM   3059 C  CZ2 . TRP B 1 158 ? -2.50707  -5.13379  19.19864  1.000 14.52763 ?  158 TRP B CZ2 1 
ATOM   3060 C  CZ3 . TRP B 1 158 ? -4.25089  -4.71917  20.82364  1.000 16.74400 ?  158 TRP B CZ3 1 
ATOM   3061 C  CH2 . TRP B 1 158 ? -3.07709  -5.37089  20.42235  1.000 15.75941 ?  158 TRP B CH2 1 
ATOM   3062 N  N   . LYS B 1 159 ? -9.10503  -1.25303  17.25319  1.000 14.99215 ?  159 LYS B N   1 
ATOM   3063 C  CA  . LYS B 1 159 ? -10.05680 -0.21704  17.62880  1.000 19.16255 ?  159 LYS B CA  1 
ATOM   3064 C  C   . LYS B 1 159 ? -9.55301  0.53351   18.85807  1.000 13.73678 ?  159 LYS B C   1 
ATOM   3065 O  O   . LYS B 1 159 ? -8.88879  -0.04924  19.71621  1.000 17.20518 ?  159 LYS B O   1 
ATOM   3066 C  CB  . LYS B 1 159 ? -11.42467 -0.81498  17.95115  1.000 17.52501 ?  159 LYS B CB  1 
ATOM   3067 C  CG  . LYS B 1 159 ? -11.96066 -1.79223  16.92869  1.000 28.12152 ?  159 LYS B CG  1 
ATOM   3068 C  CD  . LYS B 1 159 ? -12.60601 -1.06140  15.78833  1.000 30.10016 ?  159 LYS B CD  1 
ATOM   3069 C  CE  . LYS B 1 159 ? -13.60305 -1.94212  15.07777  1.000 32.97178 ?  159 LYS B CE  1 
ATOM   3070 N  NZ  . LYS B 1 159 ? -13.24919 -1.99143  13.64018  1.000 36.23075 ?  159 LYS B NZ  1 
ATOM   3071 N  N   . PRO B 1 160 ? -9.89092  1.81400   18.98304  1.000 19.77824 ?  160 PRO B N   1 
ATOM   3072 C  CA  . PRO B 1 160 ? -9.50926  2.57762   20.17954  1.000 18.51469 ?  160 PRO B CA  1 
ATOM   3073 C  C   . PRO B 1 160 ? -9.90734  1.85593   21.45706  1.000 17.44712 ?  160 PRO B C   1 
ATOM   3074 O  O   . PRO B 1 160 ? -11.06435 1.48773   21.64723  1.000 20.24913 ?  160 PRO B O   1 
ATOM   3075 C  CB  . PRO B 1 160 ? -10.28474 3.88708   20.01686  1.000 19.40591 ?  160 PRO B CB  1 
ATOM   3076 C  CG  . PRO B 1 160 ? -10.50399 4.00690   18.53419  1.000 20.22622 ?  160 PRO B CG  1 
ATOM   3077 C  CD  . PRO B 1 160 ? -10.66092 2.62120   18.02336  1.000 20.73140 ?  160 PRO B CD  1 
ATOM   3078 N  N   . GLY B 1 161 ? -8.92937  1.62429   22.32072  1.000 17.74787 ?  161 GLY B N   1 
ATOM   3079 C  CA  . GLY B 1 161 ? -9.16714  0.99275   23.60128  1.000 17.86379 ?  161 GLY B CA  1 
ATOM   3080 C  C   . GLY B 1 161 ? -9.25602  -0.51786  23.57804  1.000 18.08538 ?  161 GLY B C   1 
ATOM   3081 O  O   . GLY B 1 161 ? -9.33798  -1.13482  24.64888  1.000 22.05044 ?  161 GLY B O   1 
ATOM   3082 N  N   . ALA B 1 162 ? -9.23288  -1.14389  22.40989  1.000 13.24131 ?  162 ALA B N   1 
ATOM   3083 C  CA  . ALA B 1 162 ? -9.35273  -2.59535  22.37363  1.000 16.55628 ?  162 ALA B CA  1 
ATOM   3084 C  C   . ALA B 1 162 ? -8.13908  -3.25166  23.02377  1.000 17.29308 ?  162 ALA B C   1 
ATOM   3085 O  O   . ALA B 1 162 ? -7.01460  -2.75539  22.93748  1.000 19.71245 ?  162 ALA B O   1 
ATOM   3086 C  CB  . ALA B 1 162 ? -9.51308  -3.08453  20.93456  1.000 15.04484 ?  162 ALA B CB  1 
ATOM   3087 N  N   . ASP B 1 163 ? -8.38296  -4.37117  23.69881  1.000 17.93344 ?  163 ASP B N   1 
ATOM   3088 C  CA  . ASP B 1 163 ? -7.32223  -5.19971  24.25526  1.000 19.74443 ?  163 ASP B CA  1 
ATOM   3089 C  C   . ASP B 1 163 ? -6.66145  -6.10709  23.22569  1.000 21.85653 ?  163 ASP B C   1 
ATOM   3090 O  O   . ASP B 1 163 ? -5.64791  -6.73668  23.54617  1.000 23.18008 ?  163 ASP B O   1 
ATOM   3091 C  CB  . ASP B 1 163 ? -7.86630  -6.10608  25.36573  1.000 21.97793 ?  163 ASP B CB  1 
ATOM   3092 C  CG  . ASP B 1 163 ? -8.41322  -5.33997  26.55234  1.000 21.39445 ?  163 ASP B CG  1 
ATOM   3093 O  OD1 . ASP B 1 163 ? -7.97041  -4.20356  26.80101  1.000 21.73249 ?  163 ASP B OD1 1 
ATOM   3094 O  OD2 . ASP B 1 163 ? -9.28829  -5.90400  27.24479  1.000 23.28049 -1 163 ASP B OD2 1 
ATOM   3095 N  N   . ALA B 1 164 ? -7.23632  -6.23536  22.03253  1.000 19.34118 ?  164 ALA B N   1 
ATOM   3096 C  CA  . ALA B 1 164 ? -6.74413  -7.15240  21.01512  1.000 17.77225 ?  164 ALA B CA  1 
ATOM   3097 C  C   . ALA B 1 164 ? -7.08706  -6.56421  19.66135  1.000 17.24414 ?  164 ALA B C   1 
ATOM   3098 O  O   . ALA B 1 164 ? -8.07147  -5.82633  19.54331  1.000 17.46864 ?  164 ALA B O   1 
ATOM   3099 C  CB  . ALA B 1 164 ? -7.36352  -8.55193  21.15542  1.000 23.09838 ?  164 ALA B CB  1 
ATOM   3100 N  N   . PRO B 1 165 ? -6.29600  -6.84804  18.62874  1.000 16.18667 ?  165 PRO B N   1 
ATOM   3101 C  CA  . PRO B 1 165 ? -6.62133  -6.33856  17.29558  1.000 17.32485 ?  165 PRO B CA  1 
ATOM   3102 C  C   . PRO B 1 165 ? -7.84583  -7.04256  16.74554  1.000 18.88909 ?  165 PRO B C   1 
ATOM   3103 O  O   . PRO B 1 165 ? -8.07174  -8.22477  17.00017  1.000 23.05129 ?  165 PRO B O   1 
ATOM   3104 C  CB  . PRO B 1 165 ? -5.37838  -6.68136  16.46686  1.000 14.54689 ?  165 PRO B CB  1 
ATOM   3105 C  CG  . PRO B 1 165 ? -4.81069  -7.87230  17.13928  1.000 17.78301 ?  165 PRO B CG  1 
ATOM   3106 C  CD  . PRO B 1 165 ? -5.05907  -7.64729  18.62322  1.000 16.35081 ?  165 PRO B CD  1 
ATOM   3107 N  N   . PHE B 1 166 ? -8.64830  -6.30690  15.98893  1.000 16.24250 ?  166 PHE B N   1 
ATOM   3108 C  CA  . PHE B 1 166 ? -9.79353  -6.93466  15.35286  1.000 17.18834 ?  166 PHE B CA  1 
ATOM   3109 C  C   . PHE B 1 166 ? -9.43768  -7.53419  14.00448  1.000 18.74152 ?  166 PHE B C   1 
ATOM   3110 O  O   . PHE B 1 166 ? -10.20422 -8.34916  13.48958  1.000 17.93422 ?  166 PHE B O   1 
ATOM   3111 C  CB  . PHE B 1 166 ? -10.95185 -5.93849  15.17285  1.000 19.18420 ?  166 PHE B CB  1 
ATOM   3112 C  CG  . PHE B 1 166 ? -10.69373 -4.91329  14.12981  1.000 18.98213 ?  166 PHE B CG  1 
ATOM   3113 C  CD1 . PHE B 1 166 ? -9.91384  -3.79827  14.42448  1.000 20.36532 ?  166 PHE B CD1 1 
ATOM   3114 C  CD2 . PHE B 1 166 ? -11.20899 -5.06199  12.84717  1.000 15.24895 ?  166 PHE B CD2 1 
ATOM   3115 C  CE1 . PHE B 1 166 ? -9.65836  -2.84886  13.46328  1.000 20.11599 ?  166 PHE B CE1 1 
ATOM   3116 C  CE2 . PHE B 1 166 ? -10.95373 -4.12777  11.87698  1.000 22.50218 ?  166 PHE B CE2 1 
ATOM   3117 C  CZ  . PHE B 1 166 ? -10.17750 -3.01153  12.17677  1.000 18.63458 ?  166 PHE B CZ  1 
ATOM   3118 N  N   . TRP B 1 167 ? -8.30200  -7.15485  13.42118  1.000 16.77587 ?  167 TRP B N   1 
ATOM   3119 C  CA  . TRP B 1 167 ? -7.87792  -7.72396  12.14945  1.000 16.12010 ?  167 TRP B CA  1 
ATOM   3120 C  C   . TRP B 1 167 ? -6.37005  -7.89072  12.16799  1.000 18.30791 ?  167 TRP B C   1 
ATOM   3121 O  O   . TRP B 1 167 ? -5.65106  -7.01743  12.66300  1.000 18.07944 ?  167 TRP B O   1 
ATOM   3122 C  CB  . TRP B 1 167 ? -8.29055  -6.83792  10.96493  1.000 20.42306 ?  167 TRP B CB  1 
ATOM   3123 C  CG  . TRP B 1 167 ? -7.89888  -7.40490  9.62669   1.000 17.24549 ?  167 TRP B CG  1 
ATOM   3124 C  CD1 . TRP B 1 167 ? -8.64655  -8.22597  8.83193   1.000 20.75834 ?  167 TRP B CD1 1 
ATOM   3125 C  CD2 . TRP B 1 167 ? -6.66171  -7.19425  8.93350   1.000 13.50142 ?  167 TRP B CD2 1 
ATOM   3126 N  NE1 . TRP B 1 167 ? -7.94941  -8.53890  7.68593   1.000 19.10497 ?  167 TRP B NE1 1 
ATOM   3127 C  CE2 . TRP B 1 167 ? -6.72995  -7.91643  7.72536   1.000 19.58196 ?  167 TRP B CE2 1 
ATOM   3128 C  CE3 . TRP B 1 167 ? -5.50532  -6.46958  9.21933   1.000 15.85255 ?  167 TRP B CE3 1 
ATOM   3129 C  CZ2 . TRP B 1 167 ? -5.68562  -7.93800  6.81222   1.000 20.96909 ?  167 TRP B CZ2 1 
ATOM   3130 C  CZ3 . TRP B 1 167 ? -4.47515  -6.48264  8.30808   1.000 17.74245 ?  167 TRP B CZ3 1 
ATOM   3131 C  CH2 . TRP B 1 167 ? -4.56850  -7.21211  7.11817   1.000 21.87790 ?  167 TRP B CH2 1 
ATOM   3132 N  N   . SER B 1 168 ? -5.89490  -9.00836  11.62361  1.000 15.86705 ?  168 SER B N   1 
ATOM   3133 C  CA  . SER B 1 168 ? -4.46607  -9.23825  11.47653  1.000 18.70538 ?  168 SER B CA  1 
ATOM   3134 C  C   . SER B 1 168 ? -4.20913  -9.85891  10.11597  1.000 21.58865 ?  168 SER B C   1 
ATOM   3135 O  O   . SER B 1 168 ? -5.03103  -10.61868 9.59863   1.000 21.26023 ?  168 SER B O   1 
ATOM   3136 C  CB  . SER B 1 168 ? -3.89020  -10.14939 12.57897  1.000 17.00422 ?  168 SER B CB  1 
ATOM   3137 O  OG  . SER B 1 168 ? -3.90339  -9.48792  13.82555  1.000 27.20610 ?  168 SER B OG  1 
ATOM   3138 N  N   . GLY B 1 169 ? -3.06072  -9.51778  9.53987   1.000 18.43465 ?  169 GLY B N   1 
ATOM   3139 C  CA  . GLY B 1 169 ? -2.65994  -10.08783 8.27434   1.000 19.47824 ?  169 GLY B CA  1 
ATOM   3140 C  C   . GLY B 1 169 ? -1.22703  -9.74684  7.95619   1.000 19.19044 ?  169 GLY B C   1 
ATOM   3141 O  O   . GLY B 1 169 ? -0.79854  -8.60254  8.14876   1.000 15.05297 ?  169 GLY B O   1 
ATOM   3142 N  N   . THR B 1 170 ? -0.47215  -10.73820 7.49871   1.000 14.71602 ?  170 THR B N   1 
ATOM   3143 C  CA  . THR B 1 170 ? 0.90759   -10.52260 7.07187   1.000 17.29962 ?  170 THR B CA  1 
ATOM   3144 C  C   . THR B 1 170 ? 0.89936   -10.07191 5.62552   1.000 15.74809 ?  170 THR B C   1 
ATOM   3145 O  O   . THR B 1 170 ? 0.66353   -10.87936 4.71587   1.000 14.62372 ?  170 THR B O   1 
ATOM   3146 C  CB  . THR B 1 170 ? 1.72656   -11.79433 7.22880   1.000 11.38865 ?  170 THR B CB  1 
ATOM   3147 O  OG1 . THR B 1 170 ? 1.64786   -12.20834 8.58755   1.000 12.46168 ?  170 THR B OG1 1 
ATOM   3148 C  CG2 . THR B 1 170 ? 3.16278   -11.52898 6.86284   1.000 12.76139 ?  170 THR B CG2 1 
ATOM   3149 N  N   . LEU B 1 171 ? 1.13600   -8.78497  5.41122   1.000 12.59848 ?  171 LEU B N   1 
ATOM   3150 C  CA  . LEU B 1 171 ? 1.10076   -8.23429  4.06646   1.000 13.87103 ?  171 LEU B CA  1 
ATOM   3151 C  C   . LEU B 1 171 ? 2.29853   -8.72282  3.26419   1.000 14.60331 ?  171 LEU B C   1 
ATOM   3152 O  O   . LEU B 1 171 ? 3.43872   -8.70081  3.74453   1.000 12.10851 ?  171 LEU B O   1 
ATOM   3153 C  CB  . LEU B 1 171 ? 1.09221   -6.70345  4.13685   1.000 9.13060  ?  171 LEU B CB  1 
ATOM   3154 C  CG  . LEU B 1 171 ? -0.09617  -6.03942  4.84012   1.000 11.28691 ?  171 LEU B CG  1 
ATOM   3155 C  CD1 . LEU B 1 171 ? 0.10832   -4.53614  4.85434   1.000 12.35928 ?  171 LEU B CD1 1 
ATOM   3156 C  CD2 . LEU B 1 171 ? -1.40051  -6.38699  4.15449   1.000 12.82274 ?  171 LEU B CD2 1 
ATOM   3157 N  N   . GLU B 1 172 ? 2.04887   -9.16956  2.03402   1.000 14.29055 ?  172 GLU B N   1 
ATOM   3158 C  CA  . GLU B 1 172 ? 3.13156   -9.70842  1.22206   1.000 12.12990 ?  172 GLU B CA  1 
ATOM   3159 C  C   . GLU B 1 172 ? 3.53680   -8.72905  0.13518   1.000 12.01330 ?  172 GLU B C   1 
ATOM   3160 O  O   . GLU B 1 172 ? 2.83551   -7.76731  -0.15803  1.000 14.15677 ?  172 GLU B O   1 
ATOM   3161 C  CB  . GLU B 1 172 ? 2.75712   -11.04820 0.57706   1.000 16.81688 ?  172 GLU B CB  1 
ATOM   3162 C  CG  . GLU B 1 172 ? 2.33552   -12.11984 1.56059   1.000 15.22346 ?  172 GLU B CG  1 
ATOM   3163 C  CD  . GLU B 1 172 ? 3.35316   -12.40730 2.64366   1.000 14.52708 ?  172 GLU B CD  1 
ATOM   3164 O  OE1 . GLU B 1 172 ? 4.55953   -12.10845 2.47384   1.000 13.25581 ?  172 GLU B OE1 1 
ATOM   3165 O  OE2 . GLU B 1 172 ? 2.92850   -12.96989 3.67569   1.000 13.60070 -1 172 GLU B OE2 1 
ATOM   3166 N  N   . ALA B 1 173 ? 4.69693   -9.00715  -0.45601  1.000 15.39662 ?  173 ALA B N   1 
ATOM   3167 C  CA  . ALA B 1 173 ? 5.20502   -8.22410  -1.57070  1.000 17.19062 ?  173 ALA B CA  1 
ATOM   3168 C  C   . ALA B 1 173 ? 4.14470   -8.10210  -2.65309  1.000 17.52929 ?  173 ALA B C   1 
ATOM   3169 O  O   . ALA B 1 173 ? 3.59018   -9.10371  -3.11365  1.000 15.36221 ?  173 ALA B O   1 
ATOM   3170 C  CB  . ALA B 1 173 ? 6.46695   -8.87410  -2.13094  1.000 14.90380 ?  173 ALA B CB  1 
ATOM   3171 N  N   . GLY B 1 174 ? 3.84415   -6.86281  -3.03373  1.000 15.89131 ?  174 GLY B N   1 
ATOM   3172 C  CA  . GLY B 1 174 ? 2.77192   -6.59293  -3.97159  1.000 15.77169 ?  174 GLY B CA  1 
ATOM   3173 C  C   . GLY B 1 174 ? 1.43243   -6.31363  -3.33586  1.000 17.83119 ?  174 GLY B C   1 
ATOM   3174 O  O   . GLY B 1 174 ? 0.42445   -6.21895  -4.05679  1.000 17.08281 ?  174 GLY B O   1 
ATOM   3175 N  N   . GLN B 1 175 ? 1.37740   -6.20068  -2.01253  1.000 13.63538 ?  175 GLN B N   1 
ATOM   3176 C  CA  . GLN B 1 175 ? 0.16564   -5.82469  -1.30181  1.000 13.96609 ?  175 GLN B CA  1 
ATOM   3177 C  C   . GLN B 1 175 ? 0.36832   -4.48152  -0.62082  1.000 14.49783 ?  175 GLN B C   1 
ATOM   3178 O  O   . GLN B 1 175 ? 1.49355   -4.07010  -0.33901  1.000 16.35965 ?  175 GLN B O   1 
ATOM   3179 C  CB  . GLN B 1 175 ? -0.22567  -6.87182  -0.24994  1.000 16.30772 ?  175 GLN B CB  1 
ATOM   3180 C  CG  . GLN B 1 175 ? -0.58670  -8.22908  -0.81721  1.000 16.88171 ?  175 GLN B CG  1 
ATOM   3181 C  CD  . GLN B 1 175 ? -1.19047  -9.12535  0.23270   1.000 18.34908 ?  175 GLN B CD  1 
ATOM   3182 O  OE1 . GLN B 1 175 ? -0.47952  -9.61327  1.10705   1.000 14.82199 ?  175 GLN B OE1 1 
ATOM   3183 N  NE2 . GLN B 1 175 ? -2.51107  -9.33985  0.16757   1.000 15.59883 ?  175 GLN B NE2 1 
ATOM   3184 N  N   . ALA B 1 176 ? -0.73951  -3.78311  -0.39884  1.000 13.19250 ?  176 ALA B N   1 
ATOM   3185 C  CA  . ALA B 1 176 ? -0.74509  -2.56294  0.39133   1.000 16.35588 ?  176 ALA B CA  1 
ATOM   3186 C  C   . ALA B 1 176 ? -1.98408  -2.56768  1.26364   1.000 17.62326 ?  176 ALA B C   1 
ATOM   3187 O  O   . ALA B 1 176 ? -3.03692  -3.06175  0.85938   1.000 22.17306 ?  176 ALA B O   1 
ATOM   3188 C  CB  . ALA B 1 176 ? -0.73051  -1.27798  -0.47879  1.000 9.93122  ?  176 ALA B CB  1 
ATOM   3189 N  N   . VAL B 1 177 ? -1.85938  -2.02104  2.46687   1.000 11.26543 ?  177 VAL B N   1 
ATOM   3190 C  CA  . VAL B 1 177 ? -3.01803  -1.75055  3.29911   1.000 11.03918 ?  177 VAL B CA  1 
ATOM   3191 C  C   . VAL B 1 177 ? -3.24555  -0.24851  3.29724   1.000 14.32318 ?  177 VAL B C   1 
ATOM   3192 O  O   . VAL B 1 177 ? -2.29086  0.53787   3.34827   1.000 12.79098 ?  177 VAL B O   1 
ATOM   3193 C  CB  . VAL B 1 177 ? -2.85165  -2.29412  4.73000   1.000 15.85988 ?  177 VAL B CB  1 
ATOM   3194 C  CG1 . VAL B 1 177 ? -1.73232  -1.57406  5.47480   1.000 12.84035 ?  177 VAL B CG1 1 
ATOM   3195 C  CG2 . VAL B 1 177 ? -4.16991  -2.16655  5.49021   1.000 14.10710 ?  177 VAL B CG2 1 
ATOM   3196 N  N   . LEU B 1 178 ? -4.50497  0.14057   3.20366   1.000 13.14034 ?  178 LEU B N   1 
ATOM   3197 C  CA  . LEU B 1 178 ? -4.93752  1.52587   3.31340   1.000 13.89917 ?  178 LEU B CA  1 
ATOM   3198 C  C   . LEU B 1 178 ? -5.76204  1.62804   4.57740   1.000 15.71695 ?  178 LEU B C   1 
ATOM   3199 O  O   . LEU B 1 178 ? -6.60983  0.77227   4.82023   1.000 17.83013 ?  178 LEU B O   1 
ATOM   3200 C  CB  . LEU B 1 178 ? -5.78428  1.92674   2.10668   1.000 15.84999 ?  178 LEU B CB  1 
ATOM   3201 C  CG  . LEU B 1 178 ? -5.09241  1.86659   0.76143   1.000 17.91229 ?  178 LEU B CG  1 
ATOM   3202 C  CD1 . LEU B 1 178 ? -6.11847  2.13805   -0.26438  1.000 29.17007 ?  178 LEU B CD1 1 
ATOM   3203 C  CD2 . LEU B 1 178 ? -4.11000  2.97120   0.72423   1.000 17.87853 ?  178 LEU B CD2 1 
ATOM   3204 N  N   . LEU B 1 179 ? -5.51462  2.63461   5.40287   1.000 15.10822 ?  179 LEU B N   1 
ATOM   3205 C  CA  . LEU B 1 179 ? -6.26302  2.64900   6.64684   1.000 11.04223 ?  179 LEU B CA  1 
ATOM   3206 C  C   . LEU B 1 179 ? -6.64845  4.06210   7.04417   1.000 18.24640 ?  179 LEU B C   1 
ATOM   3207 O  O   . LEU B 1 179 ? -5.95760  5.03607   6.74316   1.000 12.29559 ?  179 LEU B O   1 
ATOM   3208 C  CB  . LEU B 1 179 ? -5.50335  1.96529   7.78400   1.000 16.57446 ?  179 LEU B CB  1 
ATOM   3209 C  CG  . LEU B 1 179 ? -4.15922  2.51590   8.18926   1.000 12.86934 ?  179 LEU B CG  1 
ATOM   3210 C  CD1 . LEU B 1 179 ? -4.28801  3.40123   9.42614   1.000 19.66414 ?  179 LEU B CD1 1 
ATOM   3211 C  CD2 . LEU B 1 179 ? -3.17661  1.38325   8.43395   1.000 15.52557 ?  179 LEU B CD2 1 
ATOM   3212 N  N   . ASP B 1 180 ? -7.78050  4.14414   7.72331   1.000 12.54504 ?  180 ASP B N   1 
ATOM   3213 C  CA  . ASP B 1 180 ? -8.19402  5.33699   8.43960   1.000 17.37886 ?  180 ASP B CA  1 
ATOM   3214 C  C   . ASP B 1 180 ? -7.31104  5.48407   9.68362   1.000 12.11908 ?  180 ASP B C   1 
ATOM   3215 O  O   . ASP B 1 180 ? -7.50790  4.80951   10.69460  1.000 15.33173 ?  180 ASP B O   1 
ATOM   3216 C  CB  . ASP B 1 180 ? -9.67550  5.20247   8.76681   1.000 16.25658 ?  180 ASP B CB  1 
ATOM   3217 C  CG  . ASP B 1 180 ? -10.15190 6.19272   9.79781   1.000 18.88390 ?  180 ASP B CG  1 
ATOM   3218 O  OD1 . ASP B 1 180 ? -9.40425  7.12265   10.17977  1.000 17.99742 ?  180 ASP B OD1 1 
ATOM   3219 O  OD2 . ASP B 1 180 ? -11.30732 6.02868   10.22763  1.000 18.10239 -1 180 ASP B OD2 1 
ATOM   3220 N  N   . ASP B 1 181 ? -6.35249  6.40376   9.61982   1.000 13.51472 ?  181 ASP B N   1 
ATOM   3221 C  CA  . ASP B 1 181 ? -5.32290  6.52176   10.64547  1.000 14.72882 ?  181 ASP B CA  1 
ATOM   3222 C  C   . ASP B 1 181 ? -5.85346  7.18481   11.90585  1.000 19.31622 ?  181 ASP B C   1 
ATOM   3223 O  O   . ASP B 1 181 ? -5.14662  7.22568   12.91937  1.000 14.60157 ?  181 ASP B O   1 
ATOM   3224 C  CB  . ASP B 1 181 ? -4.13639  7.30177   10.07633  1.000 17.49943 ?  181 ASP B CB  1 
ATOM   3225 C  CG  . ASP B 1 181 ? -2.92401  7.31358   11.01042  1.000 17.91133 ?  181 ASP B CG  1 
ATOM   3226 O  OD1 . ASP B 1 181 ? -2.55950  6.24260   11.54437  1.000 12.23133 ?  181 ASP B OD1 1 
ATOM   3227 O  OD2 . ASP B 1 181 ? -2.31819  8.38893   11.18382  1.000 17.99300 -1 181 ASP B OD2 1 
ATOM   3228 N  N   . ARG B 1 182 ? -7.07527  7.71239   11.84779  1.000 15.87492 ?  182 ARG B N   1 
ATOM   3229 C  CA  . ARG B 1 182 ? -7.77146  8.32147   12.97198  1.000 18.14764 ?  182 ARG B CA  1 
ATOM   3230 C  C   . ARG B 1 182 ? -8.67824  7.32774   13.69107  1.000 15.48387 ?  182 ARG B C   1 
ATOM   3231 O  O   . ARG B 1 182 ? -8.56328  7.15060   14.90504  1.000 18.71521 ?  182 ARG B O   1 
ATOM   3232 C  CB  . ARG B 1 182 ? -8.58072  9.52309   12.46671  1.000 14.28440 ?  182 ARG B CB  1 
ATOM   3233 C  CG  . ARG B 1 182 ? -7.68779  10.63633  11.89942  1.000 16.98823 ?  182 ARG B CG  1 
ATOM   3234 C  CD  . ARG B 1 182 ? -8.46601  11.79816  11.28299  1.000 19.43258 ?  182 ARG B CD  1 
ATOM   3235 N  NE  . ARG B 1 182 ? -7.56834  12.91846  11.01376  1.000 22.90124 ?  182 ARG B NE  1 
ATOM   3236 C  CZ  . ARG B 1 182 ? -7.90354  14.01838  10.35294  1.000 29.54216 ?  182 ARG B CZ  1 
ATOM   3237 N  NH1 . ARG B 1 182 ? -9.10957  14.17608  9.83601   1.000 20.19800 ?  182 ARG B NH1 1 
ATOM   3238 N  NH2 . ARG B 1 182 ? -7.00565  14.98651  10.21141  1.000 24.70664 ?  182 ARG B NH2 1 
ATOM   3239 N  N   . GLY B 1 183 ? -9.57069  6.66290   12.94870  1.000 16.05820 ?  183 GLY B N   1 
ATOM   3240 C  CA  . GLY B 1 183 ? -10.46275 5.67222   13.52167  1.000 16.02550 ?  183 GLY B CA  1 
ATOM   3241 C  C   . GLY B 1 183 ? -9.79090  4.40283   13.99165  1.000 17.34480 ?  183 GLY B C   1 
ATOM   3242 O  O   . GLY B 1 183 ? -10.33294 3.73078   14.87301  1.000 14.06536 ?  183 GLY B O   1 
ATOM   3243 N  N   . LEU B 1 184 ? -8.61563  4.07228   13.44921  1.000 16.14032 ?  184 LEU B N   1 
ATOM   3244 C  CA  . LEU B 1 184 ? -7.90127  2.84809   13.79540  1.000 13.72611 ?  184 LEU B CA  1 
ATOM   3245 C  C   . LEU B 1 184 ? -6.49037  3.16559   14.26627  1.000 14.01720 ?  184 LEU B C   1 
ATOM   3246 O  O   . LEU B 1 184 ? -5.86259  4.12407   13.80545  1.000 13.89948 ?  184 LEU B O   1 
ATOM   3247 C  CB  . LEU B 1 184 ? -7.80747  1.87662   12.60550  1.000 13.75099 ?  184 LEU B CB  1 
ATOM   3248 C  CG  . LEU B 1 184 ? -9.12224  1.44399   11.96327  1.000 18.06609 ?  184 LEU B CG  1 
ATOM   3249 C  CD1 . LEU B 1 184 ? -8.89475  0.47359   10.80474  1.000 11.82064 ?  184 LEU B CD1 1 
ATOM   3250 C  CD2 . LEU B 1 184 ? -9.99748  0.82582   13.03447  1.000 18.72536 ?  184 LEU B CD2 1 
ATOM   3251 N  N   . ALA B 1 185 ? -6.00118  2.36357   15.20311  1.000 13.88965 ?  185 ALA B N   1 
ATOM   3252 C  CA  . ALA B 1 185 ? -4.57899  2.31531   15.50577  1.000 12.84404 ?  185 ALA B CA  1 
ATOM   3253 C  C   . ALA B 1 185 ? -3.99279  1.05856   14.88172  1.000 13.49296 ?  185 ALA B C   1 
ATOM   3254 O  O   . ALA B 1 185 ? -4.72101  0.14994   14.47554  1.000 11.85003 ?  185 ALA B O   1 
ATOM   3255 C  CB  . ALA B 1 185 ? -4.32665  2.32625   17.01628  1.000 11.57826 ?  185 ALA B CB  1 
ATOM   3256 N  N   . HIS B 1 186 ? -2.66240  0.99725   14.81072  1.000 9.92026  ?  186 HIS B N   1 
ATOM   3257 C  CA  . HIS B 1 186 ? -2.03700  -0.18557  14.23900  1.000 10.91506 ?  186 HIS B CA  1 
ATOM   3258 C  C   . HIS B 1 186 ? -0.69049  -0.44252  14.90444  1.000 13.80775 ?  186 HIS B C   1 
ATOM   3259 O  O   . HIS B 1 186 ? -0.05576  0.47493   15.43222  1.000 9.85766  ?  186 HIS B O   1 
ATOM   3260 C  CB  . HIS B 1 186 ? -1.88214  -0.04970  12.70838  1.000 10.32241 ?  186 HIS B CB  1 
ATOM   3261 C  CG  . HIS B 1 186 ? -0.94664  1.03952   12.26921  1.000 13.05479 ?  186 HIS B CG  1 
ATOM   3262 N  ND1 . HIS B 1 186 ? -1.33561  2.35728   12.15744  1.000 11.61409 ?  186 HIS B ND1 1 
ATOM   3263 C  CD2 . HIS B 1 186 ? 0.35149   1.00198   11.88422  1.000 13.81578 ?  186 HIS B CD2 1 
ATOM   3264 C  CE1 . HIS B 1 186 ? -0.32050  3.08267   11.72590  1.000 15.52876 ?  186 HIS B CE1 1 
ATOM   3265 N  NE2 . HIS B 1 186 ? 0.71991   2.28599   11.56274  1.000 16.22303 ?  186 HIS B NE2 1 
ATOM   3266 N  N   . ASP B 1 187 ? -0.28118  -1.71154  14.90450  1.000 9.92951  ?  187 ASP B N   1 
ATOM   3267 C  CA  . ASP B 1 187 ? 1.12187   -2.06830  15.09056  1.000 11.97428 ?  187 ASP B CA  1 
ATOM   3268 C  C   . ASP B 1 187 ? 1.43190   -3.20028  14.12746  1.000 13.84490 ?  187 ASP B C   1 
ATOM   3269 O  O   . ASP B 1 187 ? 0.56224   -3.65695  13.38191  1.000 14.36066 ?  187 ASP B O   1 
ATOM   3270 C  CB  . ASP B 1 187 ? 1.46099   -2.41810  16.55454  1.000 7.25128  ?  187 ASP B CB  1 
ATOM   3271 C  CG  . ASP B 1 187 ? 0.98284   -3.80659  16.98765  1.000 16.71315 ?  187 ASP B CG  1 
ATOM   3272 O  OD1 . ASP B 1 187 ? 0.03370   -4.36399  16.40139  1.000 11.80918 ?  187 ASP B OD1 1 
ATOM   3273 O  OD2 . ASP B 1 187 ? 1.56590   -4.33063  17.95935  1.000 13.84702 -1 187 ASP B OD2 1 
ATOM   3274 N  N   . VAL B 1 188 ? 2.69279   -3.62005  14.09039  1.000 8.26065  ?  188 VAL B N   1 
ATOM   3275 C  CA  . VAL B 1 188 ? 3.11932   -4.68674  13.19317  1.000 9.52607  ?  188 VAL B CA  1 
ATOM   3276 C  C   . VAL B 1 188 ? 4.13994   -5.53442  13.93856  1.000 13.26858 ?  188 VAL B C   1 
ATOM   3277 O  O   . VAL B 1 188 ? 5.05212   -4.98521  14.56587  1.000 11.92918 ?  188 VAL B O   1 
ATOM   3278 C  CB  . VAL B 1 188 ? 3.74219   -4.14745  11.88647  1.000 10.68219 ?  188 VAL B CB  1 
ATOM   3279 C  CG1 . VAL B 1 188 ? 3.93699   -5.30541  10.89615  1.000 12.34127 ?  188 VAL B CG1 1 
ATOM   3280 C  CG2 . VAL B 1 188 ? 2.91398   -3.04656  11.26989  1.000 10.10803 ?  188 VAL B CG2 1 
ATOM   3281 N  N   . THR B 1 189 ? 3.99896   -6.86255  13.87865  1.000 9.61613  ?  189 THR B N   1 
ATOM   3282 C  CA  . THR B 1 189 ? 4.94958   -7.67715  14.62032  1.000 11.57555 ?  189 THR B CA  1 
ATOM   3283 C  C   . THR B 1 189 ? 6.31342   -7.58802  13.96280  1.000 10.27968 ?  189 THR B C   1 
ATOM   3284 O  O   . THR B 1 189 ? 6.43996   -7.28641  12.76154  1.000 8.90659  ?  189 THR B O   1 
ATOM   3285 C  CB  . THR B 1 189 ? 4.52575   -9.15048  14.70002  1.000 11.44858 ?  189 THR B CB  1 
ATOM   3286 O  OG1 . THR B 1 189 ? 4.40387   -9.68752  13.38388  1.000 11.02862 ?  189 THR B OG1 1 
ATOM   3287 C  CG2 . THR B 1 189 ? 3.22429   -9.32730  15.44730  1.000 12.23393 ?  189 THR B CG2 1 
ATOM   3288 N  N   . ASP B 1 190 ? 7.34249   -7.87877  14.76263  1.000 10.09974 ?  190 ASP B N   1 
ATOM   3289 C  CA  . ASP B 1 190 ? 8.70806   -7.81496  14.27100  1.000 11.98099 ?  190 ASP B CA  1 
ATOM   3290 C  C   . ASP B 1 190 ? 8.90262   -8.72006  13.06571  1.000 13.66493 ?  190 ASP B C   1 
ATOM   3291 O  O   . ASP B 1 190 ? 8.29374   -9.78415  12.95546  1.000 13.43425 ?  190 ASP B O   1 
ATOM   3292 C  CB  . ASP B 1 190 ? 9.71367   -8.22736  15.34401  1.000 13.63187 ?  190 ASP B CB  1 
ATOM   3293 C  CG  . ASP B 1 190 ? 9.74941   -7.26468  16.50885  1.000 21.10357 ?  190 ASP B CG  1 
ATOM   3294 O  OD1 . ASP B 1 190 ? 9.26897   -6.11349  16.36912  1.000 14.75444 ?  190 ASP B OD1 1 
ATOM   3295 O  OD2 . ASP B 1 190 ? 10.24729  -7.67798  17.57777  1.000 21.48736 -1 190 ASP B OD2 1 
ATOM   3296 N  N   . VAL B 1 191 ? 9.76593   -8.25917  12.16158  1.000 12.81735 ?  191 VAL B N   1 
ATOM   3297 C  CA  . VAL B 1 191 ? 10.32651  -9.08098  11.10651  1.000 13.91977 ?  191 VAL B CA  1 
ATOM   3298 C  C   . VAL B 1 191 ? 11.26247  -10.10552 11.72479  1.000 18.38029 ?  191 VAL B C   1 
ATOM   3299 O  O   . VAL B 1 191 ? 12.13650  -9.76419  12.53355  1.000 13.97048 ?  191 VAL B O   1 
ATOM   3300 C  CB  . VAL B 1 191 ? 11.07092  -8.19310  10.10425  1.000 16.62742 ?  191 VAL B CB  1 
ATOM   3301 C  CG1 . VAL B 1 191 ? 11.77152  -9.03236  9.09337   1.000 19.09622 ?  191 VAL B CG1 1 
ATOM   3302 C  CG2 . VAL B 1 191 ? 10.10345  -7.25771  9.42743   1.000 18.45549 ?  191 VAL B CG2 1 
ATOM   3303 N  N   . LEU B 1 192 ? 11.08934  -11.36362 11.34718  1.000 16.69692 ?  192 LEU B N   1 
ATOM   3304 C  CA  . LEU B 1 192 ? 11.94123  -12.44012 11.82482  1.000 18.92112 ?  192 LEU B CA  1 
ATOM   3305 C  C   . LEU B 1 192 ? 12.73222  -13.03200 10.66858  1.000 20.46137 ?  192 LEU B C   1 
ATOM   3306 O  O   . LEU B 1 192 ? 12.22480  -13.12469 9.54811   1.000 17.36520 ?  192 LEU B O   1 
ATOM   3307 C  CB  . LEU B 1 192 ? 11.10957  -13.53636 12.48577  1.000 20.33229 ?  192 LEU B CB  1 
ATOM   3308 C  CG  . LEU B 1 192 ? 10.19946  -13.04993 13.60611  1.000 22.06106 ?  192 LEU B CG  1 
ATOM   3309 C  CD1 . LEU B 1 192 ? 9.37206   -14.20056 14.15978  1.000 25.21805 ?  192 LEU B CD1 1 
ATOM   3310 C  CD2 . LEU B 1 192 ? 11.06029  -12.42514 14.68521  1.000 19.29752 ?  192 LEU B CD2 1 
ATOM   3311 N  N   . SER B 1 193 ? 13.97591  -13.42929 10.94543  1.000 14.84670 ?  193 SER B N   1 
ATOM   3312 C  CA  . SER B 1 193 ? 14.74316  -14.21284 9.98721   1.000 19.02246 ?  193 SER B CA  1 
ATOM   3313 C  C   . SER B 1 193 ? 14.02886  -15.53509 9.75356   1.000 19.28949 ?  193 SER B C   1 
ATOM   3314 O  O   . SER B 1 193 ? 13.61800  -16.20239 10.70529  1.000 19.14298 ?  193 SER B O   1 
ATOM   3315 C  CB  . SER B 1 193 ? 16.16005  -14.44837 10.51085  1.000 22.23130 ?  193 SER B CB  1 
ATOM   3316 O  OG  . SER B 1 193 ? 16.89399  -15.30606 9.66413   1.000 22.55672 ?  193 SER B OG  1 
ATOM   3317 N  N   . ALA B 1 194 ? 13.83245  -15.89636 8.48558   1.000 20.50761 ?  194 ALA B N   1 
ATOM   3318 C  CA  . ALA B 1 194 ? 13.06177  -17.10309 8.19800   1.000 22.39567 ?  194 ALA B CA  1 
ATOM   3319 C  C   . ALA B 1 194 ? 13.85975  -18.38917 8.41878   1.000 21.87130 ?  194 ALA B C   1 
ATOM   3320 O  O   . ALA B 1 194 ? 13.27224  -19.42725 8.74423   1.000 22.73622 ?  194 ALA B O   1 
ATOM   3321 C  CB  . ALA B 1 194 ? 12.53251  -17.05411 6.76385   1.000 20.56207 ?  194 ALA B CB  1 
ATOM   3322 N  N   . ASP B 1 195 ? 15.17521  -18.34649 8.26124   1.000 23.19307 ?  195 ASP B N   1 
ATOM   3323 C  CA  . ASP B 1 195 ? 15.97373  -19.55853 8.36323   1.000 23.68615 ?  195 ASP B CA  1 
ATOM   3324 C  C   . ASP B 1 195 ? 17.16768  -19.39176 9.28838   1.000 29.16979 ?  195 ASP B C   1 
ATOM   3325 O  O   . ASP B 1 195 ? 17.98680  -20.31509 9.38181   1.000 25.07400 ?  195 ASP B O   1 
ATOM   3326 C  CB  . ASP B 1 195 ? 16.47328  -19.98152 6.98179   1.000 22.80304 ?  195 ASP B CB  1 
ATOM   3327 C  CG  . ASP B 1 195 ? 17.40987  -18.96344 6.38338   1.000 26.44694 ?  195 ASP B CG  1 
ATOM   3328 O  OD1 . ASP B 1 195 ? 17.57447  -17.88030 6.99256   1.000 27.47120 ?  195 ASP B OD1 1 
ATOM   3329 O  OD2 . ASP B 1 195 ? 17.98020  -19.23054 5.30586   1.000 28.41816 -1 195 ASP B OD2 1 
ATOM   3330 N  N   . GLY B 1 196 ? 17.31949  -18.23751 9.93504   1.000 24.85025 ?  196 GLY B N   1 
ATOM   3331 C  CA  . GLY B 1 196 ? 18.46723  -17.95896 10.76243  1.000 20.68147 ?  196 GLY B CA  1 
ATOM   3332 C  C   . GLY B 1 196 ? 19.48915  -17.05559 10.11229  1.000 19.03901 ?  196 GLY B C   1 
ATOM   3333 O  O   . GLY B 1 196 ? 20.35750  -16.51484 10.81047  1.000 24.18465 ?  196 GLY B O   1 
ATOM   3334 N  N   . GLY B 1 197 ? 19.41278  -16.87726 8.80049   1.000 18.66320 ?  197 GLY B N   1 
ATOM   3335 C  CA  . GLY B 1 197 ? 20.29830  -15.96713 8.11969   1.000 22.04818 ?  197 GLY B CA  1 
ATOM   3336 C  C   . GLY B 1 197 ? 19.66580  -14.60037 7.92956   1.000 24.36249 ?  197 GLY B C   1 
ATOM   3337 O  O   . GLY B 1 197 ? 18.54947  -14.33273 8.38482   1.000 18.70860 ?  197 GLY B O   1 
ATOM   3338 N  N   . PRO B 1 198 ? 20.37836  -13.71029 7.24868   1.000 16.85334 ?  198 PRO B N   1 
ATOM   3339 C  CA  . PRO B 1 198 ? 19.84814  -12.36514 6.99989   1.000 20.29528 ?  198 PRO B CA  1 
ATOM   3340 C  C   . PRO B 1 198 ? 18.60685  -12.37228 6.11610   1.000 24.88576 ?  198 PRO B C   1 
ATOM   3341 O  O   . PRO B 1 198 ? 18.41710  -13.23038 5.25264   1.000 15.74184 ?  198 PRO B O   1 
ATOM   3342 C  CB  . PRO B 1 198 ? 21.01304  -11.64722 6.30832   1.000 20.24267 ?  198 PRO B CB  1 
ATOM   3343 C  CG  . PRO B 1 198 ? 21.86634  -12.74974 5.75997   1.000 28.35944 ?  198 PRO B CG  1 
ATOM   3344 C  CD  . PRO B 1 198 ? 21.74775  -13.87355 6.73744   1.000 21.24532 ?  198 PRO B CD  1 
ATOM   3345 N  N   . GLY B 1 199 ? 17.74891  -11.38566 6.35313   1.000 16.12208 ?  199 GLY B N   1 
ATOM   3346 C  CA  . GLY B 1 199 ? 16.56737  -11.17258 5.54234   1.000 17.75258 ?  199 GLY B CA  1 
ATOM   3347 C  C   . GLY B 1 199 ? 16.14536  -9.72796  5.70040   1.000 15.82686 ?  199 GLY B C   1 
ATOM   3348 O  O   . GLY B 1 199 ? 16.57138  -9.03774  6.63049   1.000 13.79294 ?  199 GLY B O   1 
ATOM   3349 N  N   . HIS B 1 200 ? 15.29156  -9.27242  4.78829   1.000 16.32380 ?  200 HIS B N   1 
ATOM   3350 C  CA  . HIS B 1 200 ? 14.86224  -7.88384  4.85074   1.000 14.76241 ?  200 HIS B CA  1 
ATOM   3351 C  C   . HIS B 1 200 ? 13.44875  -7.75730  4.30510   1.000 17.42506 ?  200 HIS B C   1 
ATOM   3352 O  O   . HIS B 1 200 ? 12.92215  -8.66801  3.65814   1.000 15.29904 ?  200 HIS B O   1 
ATOM   3353 C  CB  . HIS B 1 200 ? 15.82180  -6.98066  4.08960   1.000 14.98639 ?  200 HIS B CB  1 
ATOM   3354 C  CG  . HIS B 1 200 ? 15.89371  -7.28539  2.62885   1.000 20.16849 ?  200 HIS B CG  1 
ATOM   3355 N  ND1 . HIS B 1 200 ? 16.75229  -8.23134  2.10614   1.000 22.58614 ?  200 HIS B ND1 1 
ATOM   3356 C  CD2 . HIS B 1 200 ? 15.21272  -6.77126  1.57881   1.000 18.54354 ?  200 HIS B CD2 1 
ATOM   3357 C  CE1 . HIS B 1 200 ? 16.60350  -8.27671  0.79417   1.000 22.74793 ?  200 HIS B CE1 1 
ATOM   3358 N  NE2 . HIS B 1 200 ? 15.66925  -7.40732  0.44989   1.000 24.28058 ?  200 HIS B NE2 1 
ATOM   3359 N  N   . ARG B 1 201 ? 12.83610  -6.61176  4.60156   1.000 11.22981 ?  201 ARG B N   1 
ATOM   3360 C  CA  . ARG B 1 201 ? 11.47162  -6.29894  4.18561   1.000 10.96465 ?  201 ARG B CA  1 
ATOM   3361 C  C   . ARG B 1 201 ? 11.47375  -4.84988  3.73335   1.000 15.10491 ?  201 ARG B C   1 
ATOM   3362 O  O   . ARG B 1 201 ? 11.81930  -3.95948  4.51728   1.000 9.81538  ?  201 ARG B O   1 
ATOM   3363 C  CB  . ARG B 1 201 ? 10.46975  -6.53076  5.32969   1.000 9.83074  ?  201 ARG B CB  1 
ATOM   3364 C  CG  . ARG B 1 201 ? 8.99861   -6.12812  5.09048   1.000 7.47898  ?  201 ARG B CG  1 
ATOM   3365 C  CD  . ARG B 1 201 ? 8.17285   -6.47256  6.33413   1.000 11.15833 ?  201 ARG B CD  1 
ATOM   3366 N  NE  . ARG B 1 201 ? 6.76917   -6.05871  6.34395   1.000 11.54547 ?  201 ARG B NE  1 
ATOM   3367 C  CZ  . ARG B 1 201 ? 6.33678   -4.89662  6.82420   1.000 11.92410 ?  201 ARG B CZ  1 
ATOM   3368 N  NH1 . ARG B 1 201 ? 7.17424   -3.92047  7.12525   1.000 7.94331  ?  201 ARG B NH1 1 
ATOM   3369 N  NH2 . ARG B 1 201 ? 5.03403   -4.71391  7.01315   1.000 13.06188 ?  201 ARG B NH2 1 
ATOM   3370 N  N   . ASP B 1 202 ? 11.12451  -4.62730  2.46724   1.000 15.26598 ?  202 ASP B N   1 
ATOM   3371 C  CA  . ASP B 1 202 ? 11.20341  -3.32148  1.82354   1.000 13.05256 ?  202 ASP B CA  1 
ATOM   3372 C  C   . ASP B 1 202 ? 9.79550   -2.80509  1.55674   1.000 14.09643 ?  202 ASP B C   1 
ATOM   3373 O  O   . ASP B 1 202 ? 9.00765   -3.47330  0.87560   1.000 13.45672 ?  202 ASP B O   1 
ATOM   3374 C  CB  . ASP B 1 202 ? 11.98985  -3.41103  0.51329   1.000 18.27801 ?  202 ASP B CB  1 
ATOM   3375 C  CG  . ASP B 1 202 ? 13.43798  -3.84898  0.72047   1.000 17.20064 ?  202 ASP B CG  1 
ATOM   3376 O  OD1 . ASP B 1 202 ? 13.94214  -3.76071  1.85663   1.000 13.02719 ?  202 ASP B OD1 1 
ATOM   3377 O  OD2 . ASP B 1 202 ? 14.07694  -4.27239  -0.26197  1.000 20.46837 -1 202 ASP B OD2 1 
ATOM   3378 N  N   . ILE B 1 203 ? 9.48478   -1.61716  2.08246   1.000 13.52516 ?  203 ILE B N   1 
ATOM   3379 C  CA  . ILE B 1 203 ? 8.12786   -1.06897  2.06752   1.000 11.71685 ?  203 ILE B CA  1 
ATOM   3380 C  C   . ILE B 1 203 ? 8.16445   0.41741   1.74324   1.000 9.87612  ?  203 ILE B C   1 
ATOM   3381 O  O   . ILE B 1 203 ? 9.22340   1.04597   1.69192   1.000 11.49751 ?  203 ILE B O   1 
ATOM   3382 C  CB  . ILE B 1 203 ? 7.40873   -1.25790  3.41698   1.000 13.04556 ?  203 ILE B CB  1 
ATOM   3383 C  CG1 . ILE B 1 203 ? 8.05816   -0.35923  4.46765   1.000 13.81097 ?  203 ILE B CG1 1 
ATOM   3384 C  CG2 . ILE B 1 203 ? 7.42287   -2.72741  3.84578   1.000 12.80261 ?  203 ILE B CG2 1 
ATOM   3385 C  CD1 . ILE B 1 203 ? 7.32873   -0.31626  5.80407   1.000 10.70975 ?  203 ILE B CD1 1 
ATOM   3386 N  N   . VAL B 1 204 ? 6.97777   0.98457   1.52251   1.000 10.65359 ?  204 VAL B N   1 
ATOM   3387 C  CA  . VAL B 1 204 ? 6.79270   2.42940   1.52458   1.000 9.23113  ?  204 VAL B CA  1 
ATOM   3388 C  C   . VAL B 1 204 ? 5.58301   2.74861   2.37800   1.000 13.84558 ?  204 VAL B C   1 
ATOM   3389 O  O   . VAL B 1 204 ? 4.53673   2.09994   2.25650   1.000 12.36887 ?  204 VAL B O   1 
ATOM   3390 C  CB  . VAL B 1 204 ? 6.61525   3.02796   0.11773   1.000 15.53543 ?  204 VAL B CB  1 
ATOM   3391 C  CG1 . VAL B 1 204 ? 6.72370   4.56197   0.17346   1.000 13.40926 ?  204 VAL B CG1 1 
ATOM   3392 C  CG2 . VAL B 1 204 ? 7.65496   2.51965   -0.76694  1.000 24.37806 ?  204 VAL B CG2 1 
ATOM   3393 N  N   . ILE B 1 205 ? 5.74356   3.73709   3.24883   1.000 14.24661 ?  205 ILE B N   1 
ATOM   3394 C  CA  . ILE B 1 205 ? 4.67438   4.28870   4.06648   1.000 11.04296 ?  205 ILE B CA  1 
ATOM   3395 C  C   . ILE B 1 205 ? 4.36014   5.66137   3.50759   1.000 14.82947 ?  205 ILE B C   1 
ATOM   3396 O  O   . ILE B 1 205 ? 5.26987   6.48387   3.34176   1.000 12.15690 ?  205 ILE B O   1 
ATOM   3397 C  CB  . ILE B 1 205 ? 5.09937   4.39252   5.53898   1.000 13.33474 ?  205 ILE B CB  1 
ATOM   3398 C  CG1 . ILE B 1 205 ? 5.60497   3.03002   6.04301   1.000 10.79982 ?  205 ILE B CG1 1 
ATOM   3399 C  CG2 . ILE B 1 205 ? 3.94054   4.87135   6.37497   1.000 15.51250 ?  205 ILE B CG2 1 
ATOM   3400 C  CD1 . ILE B 1 205 ? 6.03094   3.02841   7.51689   1.000 12.28031 ?  205 ILE B CD1 1 
ATOM   3401 N  N   . ILE B 1 206 ? 3.08493   5.90026   3.20681   1.000 15.68502 ?  206 ILE B N   1 
ATOM   3402 C  CA  . ILE B 1 206 ? 2.60546   7.19019   2.72220   1.000 16.22607 ?  206 ILE B CA  1 
ATOM   3403 C  C   . ILE B 1 206 ? 1.55209   7.68959   3.69881   1.000 12.88343 ?  206 ILE B C   1 
ATOM   3404 O  O   . ILE B 1 206 ? 0.51942   7.03417   3.89395   1.000 14.01154 ?  206 ILE B O   1 
ATOM   3405 C  CB  . ILE B 1 206 ? 2.02052   7.10623   1.29654   1.000 13.39667 ?  206 ILE B CB  1 
ATOM   3406 C  CG1 . ILE B 1 206 ? 3.00743   6.44628   0.32789   1.000 13.56765 ?  206 ILE B CG1 1 
ATOM   3407 C  CG2 . ILE B 1 206 ? 1.67664   8.49263   0.78914   1.000 16.34154 ?  206 ILE B CG2 1 
ATOM   3408 C  CD1 . ILE B 1 206 ? 2.69942   4.99481   0.02527   1.000 15.66448 ?  206 ILE B CD1 1 
ATOM   3409 N  N   . ALA B 1 207 ? 1.78959   8.85657   4.28955   1.000 13.34663 ?  207 ALA B N   1 
ATOM   3410 C  CA  . ALA B 1 207 ? 0.85267   9.44529   5.23818   1.000 11.38129 ?  207 ALA B CA  1 
ATOM   3411 C  C   . ALA B 1 207 ? 0.17041   10.64666  4.59946   1.000 14.53506 ?  207 ALA B C   1 
ATOM   3412 O  O   . ALA B 1 207 ? 0.84205   11.59121  4.16260   1.000 11.51335 ?  207 ALA B O   1 
ATOM   3413 C  CB  . ALA B 1 207 ? 1.55909   9.84137   6.53622   1.000 8.45791  ?  207 ALA B CB  1 
ATOM   3414 N  N   . PHE B 1 208 ? -1.15729  10.61411  4.57970   1.000 13.00440 ?  208 PHE B N   1 
ATOM   3415 C  CA  . PHE B 1 208 ? -1.98438  11.57947  3.86797   1.000 15.08513 ?  208 PHE B CA  1 
ATOM   3416 C  C   . PHE B 1 208 ? -2.57987  12.58496  4.84274   1.000 13.74920 ?  208 PHE B C   1 
ATOM   3417 O  O   . PHE B 1 208 ? -3.22728  12.20246  5.82442   1.000 15.77945 ?  208 PHE B O   1 
ATOM   3418 C  CB  . PHE B 1 208 ? -3.13075  10.87912  3.12194   1.000 12.68079 ?  208 PHE B CB  1 
ATOM   3419 C  CG  . PHE B 1 208 ? -2.68850  9.93659   2.05444   1.000 15.30264 ?  208 PHE B CG  1 
ATOM   3420 C  CD1 . PHE B 1 208 ? -2.34514  8.63170   2.36095   1.000 16.07622 ?  208 PHE B CD1 1 
ATOM   3421 C  CD2 . PHE B 1 208 ? -2.65755  10.34260  0.73110   1.000 20.72715 ?  208 PHE B CD2 1 
ATOM   3422 C  CE1 . PHE B 1 208 ? -1.96432  7.74437   1.36086   1.000 13.06801 ?  208 PHE B CE1 1 
ATOM   3423 C  CE2 . PHE B 1 208 ? -2.26617  9.47234   -0.26950  1.000 16.44099 ?  208 PHE B CE2 1 
ATOM   3424 C  CZ  . PHE B 1 208 ? -1.92052  8.16829   0.04712   1.000 15.90848 ?  208 PHE B CZ  1 
ATOM   3425 N  N   . SER B 1 209 ? -2.39709  13.86265  4.54190   1.000 15.43730 ?  209 SER B N   1 
ATOM   3426 C  CA  . SER B 1 209 ? -2.97275  14.95468  5.30458   1.000 14.76865 ?  209 SER B CA  1 
ATOM   3427 C  C   . SER B 1 209 ? -3.42693  16.02122  4.32324   1.000 16.12877 ?  209 SER B C   1 
ATOM   3428 O  O   . SER B 1 209 ? -2.74217  16.28591  3.32966   1.000 17.52815 ?  209 SER B O   1 
ATOM   3429 C  CB  . SER B 1 209 ? -1.96268  15.55385  6.29378   1.000 18.06408 ?  209 SER B CB  1 
ATOM   3430 O  OG  . SER B 1 209 ? -1.78039  14.72346  7.42533   1.000 20.67551 ?  209 SER B OG  1 
ATOM   3431 N  N   . ARG B 1 210 ? -4.59616  16.59908  4.58482   1.000 21.98538 ?  210 ARG B N   1 
ATOM   3432 C  CA  . ARG B 1 210 ? -5.03574  17.75819  3.81950   1.000 18.42579 ?  210 ARG B CA  1 
ATOM   3433 C  C   . ARG B 1 210 ? -3.99762  18.85703  3.93118   1.000 17.71252 ?  210 ARG B C   1 
ATOM   3434 O  O   . ARG B 1 210 ? -3.40138  19.05343  4.99644   1.000 16.69568 ?  210 ARG B O   1 
ATOM   3435 C  CB  . ARG B 1 210 ? -6.38804  18.25086  4.32706   1.000 16.35356 ?  210 ARG B CB  1 
ATOM   3436 C  CG  . ARG B 1 210 ? -7.48264  17.24330  4.04217   1.000 18.23642 ?  210 ARG B CG  1 
ATOM   3437 C  CD  . ARG B 1 210 ? -8.74052  17.51377  4.80558   1.000 19.76070 ?  210 ARG B CD  1 
ATOM   3438 N  NE  . ARG B 1 210 ? -9.57447  16.31798  4.80911   1.000 25.02460 ?  210 ARG B NE  1 
ATOM   3439 C  CZ  . ARG B 1 210 ? -10.57914 16.09153  3.97134   1.000 31.12293 ?  210 ARG B CZ  1 
ATOM   3440 N  NH1 . ARG B 1 210 ? -10.95247 16.99143  3.07634   1.000 28.82896 ?  210 ARG B NH1 1 
ATOM   3441 N  NH2 . ARG B 1 210 ? -11.23052 14.93443  4.03665   1.000 25.41046 ?  210 ARG B NH2 1 
ATOM   3442 N  N   . TRP B 1 211 ? -3.76411  19.55564  2.81548   1.000 14.78753 ?  211 TRP B N   1 
ATOM   3443 C  CA  . TRP B 1 211 ? -2.74611  20.60162  2.78935   1.000 17.21049 ?  211 TRP B CA  1 
ATOM   3444 C  C   . TRP B 1 211 ? -2.96308  21.60437  3.91642   1.000 12.91634 ?  211 TRP B C   1 
ATOM   3445 O  O   . TRP B 1 211 ? -1.99782  22.09676  4.50535   1.000 20.15875 ?  211 TRP B O   1 
ATOM   3446 C  CB  . TRP B 1 211 ? -2.73910  21.29709  1.41655   1.000 16.23514 ?  211 TRP B CB  1 
ATOM   3447 C  CG  . TRP B 1 211 ? -1.66119  22.34053  1.29814   1.000 17.15463 ?  211 TRP B CG  1 
ATOM   3448 C  CD1 . TRP B 1 211 ? -1.78962  23.67899  1.51904   1.000 15.44040 ?  211 TRP B CD1 1 
ATOM   3449 C  CD2 . TRP B 1 211 ? -0.28179  22.11998  0.96957   1.000 14.34457 ?  211 TRP B CD2 1 
ATOM   3450 N  NE1 . TRP B 1 211 ? -0.57555  24.30851  1.34311   1.000 10.90381 ?  211 TRP B NE1 1 
ATOM   3451 C  CE2 . TRP B 1 211 ? 0.36214   23.37691  0.99776   1.000 15.80781 ?  211 TRP B CE2 1 
ATOM   3452 C  CE3 . TRP B 1 211 ? 0.46710   20.98513  0.64034   1.000 16.08195 ?  211 TRP B CE3 1 
ATOM   3453 C  CZ2 . TRP B 1 211 ? 1.72075   23.52834  0.72731   1.000 20.91883 ?  211 TRP B CZ2 1 
ATOM   3454 C  CZ3 . TRP B 1 211 ? 1.82332   21.13609  0.37354   1.000 14.30350 ?  211 TRP B CZ3 1 
ATOM   3455 C  CH2 . TRP B 1 211 ? 2.43428   22.40181  0.42161   1.000 18.78432 ?  211 TRP B CH2 1 
ATOM   3456 N  N   . ALA B 1 212 ? -4.22428  21.88051  4.25676   1.000 16.83956 ?  212 ALA B N   1 
ATOM   3457 C  CA  . ALA B 1 212 ? -4.56802  22.78241  5.34863   1.000 20.19087 ?  212 ALA B CA  1 
ATOM   3458 C  C   . ALA B 1 212 ? -4.07270  22.27301  6.69470   1.000 21.40813 ?  212 ALA B C   1 
ATOM   3459 O  O   . ALA B 1 212 ? -3.99146  23.05944  7.64751   1.000 18.30259 ?  212 ALA B O   1 
ATOM   3460 C  CB  . ALA B 1 212 ? -6.08853  22.98167  5.39481   1.000 15.65741 ?  212 ALA B CB  1 
ATOM   3461 N  N   . GLU B 1 213 ? -3.75935  20.97844  6.78913   1.000 23.53418 ?  213 GLU B N   1 
ATOM   3462 C  CA  . GLU B 1 213 ? -3.24394  20.33285  7.99058   1.000 21.48293 ?  213 GLU B CA  1 
ATOM   3463 C  C   . GLU B 1 213 ? -1.88685  19.69466  7.70574   1.000 22.05587 ?  213 GLU B C   1 
ATOM   3464 O  O   . GLU B 1 213 ? -1.53579  18.67350  8.30509   1.000 20.96660 ?  213 GLU B O   1 
ATOM   3465 C  CB  . GLU B 1 213 ? -4.23359  19.27813  8.49722   1.000 19.49582 ?  213 GLU B CB  1 
ATOM   3466 C  CG  . GLU B 1 213 ? -5.66100  19.77694  8.67606   1.000 25.00236 ?  213 GLU B CG  1 
ATOM   3467 C  CD  . GLU B 1 213 ? -6.68564  18.65203  8.83356   1.000 27.96910 ?  213 GLU B CD  1 
ATOM   3468 O  OE1 . GLU B 1 213 ? -6.29743  17.51750  9.13380   1.000 29.93474 ?  213 GLU B OE1 1 
ATOM   3469 O  OE2 . GLU B 1 213 ? -7.89203  18.89979  8.65263   1.000 46.37380 -1 213 GLU B OE2 1 
ATOM   3470 N  N   . LYS B 1 214 ? -1.12176  20.28487  6.78123   1.000 16.36362 ?  214 LYS B N   1 
ATOM   3471 C  CA  . LYS B 1 214 ? 0.06249   19.62737  6.24016   1.000 17.87346 ?  214 LYS B CA  1 
ATOM   3472 C  C   . LYS B 1 214 ? 1.11598   19.39191  7.31525   1.000 19.41236 ?  214 LYS B C   1 
ATOM   3473 O  O   . LYS B 1 214 ? 1.27167   20.18961  8.24101   1.000 17.87332 ?  214 LYS B O   1 
ATOM   3474 C  CB  . LYS B 1 214 ? 0.66962   20.46754  5.11644   1.000 21.21825 ?  214 LYS B CB  1 
ATOM   3475 C  CG  . LYS B 1 214 ? 1.13981   21.87218  5.53265   1.000 20.68404 ?  214 LYS B CG  1 
ATOM   3476 C  CD  . LYS B 1 214 ? 1.50893   22.70172  4.28067   1.000 22.31728 ?  214 LYS B CD  1 
ATOM   3477 C  CE  . LYS B 1 214 ? 2.02016   24.11904  4.61342   1.000 18.02036 ?  214 LYS B CE  1 
ATOM   3478 N  NZ  . LYS B 1 214 ? 1.06011   24.88462  5.46484   1.000 18.31705 ?  214 LYS B NZ  1 
ATOM   3479 N  N   . TRP B 1 215 ? 1.87495   18.30934  7.15501   1.000 14.75484 ?  215 TRP B N   1 
ATOM   3480 C  CA  . TRP B 1 215 ? 2.99569   17.96469  8.03671   1.000 16.64252 ?  215 TRP B CA  1 
ATOM   3481 C  C   . TRP B 1 215 ? 4.30874   18.49327  7.47560   1.000 19.25755 ?  215 TRP B C   1 
ATOM   3482 O  O   . TRP B 1 215 ? 5.30942   17.78256  7.37052   1.000 16.42363 ?  215 TRP B O   1 
ATOM   3483 C  CB  . TRP B 1 215 ? 3.05209   16.44750  8.24512   1.000 18.13369 ?  215 TRP B CB  1 
ATOM   3484 C  CG  . TRP B 1 215 ? 2.00843   15.92329  9.22076   1.000 19.53668 ?  215 TRP B CG  1 
ATOM   3485 C  CD1 . TRP B 1 215 ? 0.65869   16.16965  9.19877   1.000 17.87254 ?  215 TRP B CD1 1 
ATOM   3486 C  CD2 . TRP B 1 215 ? 2.23885   15.06993  10.35496  1.000 15.99925 ?  215 TRP B CD2 1 
ATOM   3487 N  NE1 . TRP B 1 215 ? 0.04079   15.53076  10.25738  1.000 15.14044 ?  215 TRP B NE1 1 
ATOM   3488 C  CE2 . TRP B 1 215 ? 0.98868   14.84763  10.97666  1.000 16.89559 ?  215 TRP B CE2 1 
ATOM   3489 C  CE3 . TRP B 1 215 ? 3.38168   14.47313  10.90273  1.000 18.30053 ?  215 TRP B CE3 1 
ATOM   3490 C  CZ2 . TRP B 1 215 ? 0.84940   14.04630  12.11783  1.000 15.88311 ?  215 TRP B CZ2 1 
ATOM   3491 C  CZ3 . TRP B 1 215 ? 3.24224   13.67629  12.03699  1.000 12.00770 ?  215 TRP B CZ3 1 
ATOM   3492 C  CH2 . TRP B 1 215 ? 1.98874   13.47671  12.63329  1.000 13.18519 ?  215 TRP B CH2 1 
ATOM   3493 N  N   . TYR B 1 216 ? 4.31028   19.77634  7.11808   1.000 20.72650 ?  216 TYR B N   1 
ATOM   3494 C  CA  . TYR B 1 216 ? 5.38763   20.34922  6.31766   1.000 17.94548 ?  216 TYR B CA  1 
ATOM   3495 C  C   . TYR B 1 216 ? 5.50529   21.83048  6.64859   1.000 20.38242 ?  216 TYR B C   1 
ATOM   3496 O  O   . TYR B 1 216 ? 4.48921   22.53094  6.67681   1.000 19.23382 ?  216 TYR B O   1 
ATOM   3497 C  CB  . TYR B 1 216 ? 5.10391   20.17923  4.81301   1.000 23.06886 ?  216 TYR B CB  1 
ATOM   3498 C  CG  . TYR B 1 216 ? 6.24614   20.63283  3.92648   1.000 23.53108 ?  216 TYR B CG  1 
ATOM   3499 C  CD1 . TYR B 1 216 ? 7.30418   19.78235  3.65869   1.000 19.84303 ?  216 TYR B CD1 1 
ATOM   3500 C  CD2 . TYR B 1 216 ? 6.27382   21.91735  3.37327   1.000 23.18437 ?  216 TYR B CD2 1 
ATOM   3501 C  CE1 . TYR B 1 216 ? 8.36441   20.17691  2.86502   1.000 19.84493 ?  216 TYR B CE1 1 
ATOM   3502 C  CE2 . TYR B 1 216 ? 7.33625   22.33157  2.56683   1.000 21.83068 ?  216 TYR B CE2 1 
ATOM   3503 C  CZ  . TYR B 1 216 ? 8.38029   21.44924  2.31763   1.000 23.91924 ?  216 TYR B CZ  1 
ATOM   3504 O  OH  . TYR B 1 216 ? 9.45534   21.81150  1.53215   1.000 16.78264 ?  216 TYR B OH  1 
ATOM   3505 N  N   . GLY B 1 217 ? 6.72062   22.30700  6.86750   1.000 16.22222 ?  217 GLY B N   1 
ATOM   3506 C  CA  . GLY B 1 217 ? 6.95039   23.72659  7.06718   1.000 25.12300 ?  217 GLY B CA  1 
ATOM   3507 C  C   . GLY B 1 217 ? 7.24346   24.07254  8.52273   1.000 23.39232 ?  217 GLY B C   1 
ATOM   3508 O  O   . GLY B 1 217 ? 7.20023   23.23334  9.42141   1.000 18.33984 ?  217 GLY B O   1 
ATOM   3509 N  N   . ASP B 1 218 ? 7.53362   25.36420  8.74352   1.000 28.95807 ?  218 ASP B N   1 
ATOM   3510 C  CA  . ASP B 1 218 ? 8.01173   25.81751  10.05430  1.000 27.82873 ?  218 ASP B CA  1 
ATOM   3511 C  C   . ASP B 1 218 ? 6.94392   25.68637  11.12990  1.000 20.18744 ?  218 ASP B C   1 
ATOM   3512 O  O   . ASP B 1 218 ? 7.25502   25.41421  12.29625  1.000 22.94560 ?  218 ASP B O   1 
ATOM   3513 C  CB  . ASP B 1 218 ? 8.46710   27.27726  9.99598   1.000 36.65408 ?  218 ASP B CB  1 
ATOM   3514 C  CG  . ASP B 1 218 ? 9.51301   27.52973  8.94505   1.000 37.67402 ?  218 ASP B CG  1 
ATOM   3515 O  OD1 . ASP B 1 218 ? 10.35903  26.63613  8.70650   1.000 34.67334 ?  218 ASP B OD1 1 
ATOM   3516 O  OD2 . ASP B 1 218 ? 9.48274   28.64406  8.37190   1.000 43.66399 -1 218 ASP B OD2 1 
ATOM   3517 N  N   . GLU B 1 219 ? 5.68868   25.94306  10.77920  1.000 19.63800 ?  219 GLU B N   1 
ATOM   3518 C  CA  . GLU B 1 219 ? 4.62628   25.83284  11.76879  1.000 17.35553 ?  219 GLU B CA  1 
ATOM   3519 C  C   . GLU B 1 219 ? 4.46159   24.38975  12.22016  1.000 20.99307 ?  219 GLU B C   1 
ATOM   3520 O  O   . GLU B 1 219 ? 4.36046   24.10959  13.41940  1.000 18.54494 ?  219 GLU B O   1 
ATOM   3521 C  CB  . GLU B 1 219 ? 3.32152   26.37326  11.18839  1.000 24.94121 ?  219 GLU B CB  1 
ATOM   3522 C  CG  . GLU B 1 219 ? 2.15877   26.37211  12.15307  1.000 29.18305 ?  219 GLU B CG  1 
ATOM   3523 C  CD  . GLU B 1 219 ? 0.83787   26.70396  11.46916  1.000 31.43063 ?  219 GLU B CD  1 
ATOM   3524 O  OE1 . GLU B 1 219 ? 0.84023   26.90917  10.23942  1.000 41.30301 ?  219 GLU B OE1 1 
ATOM   3525 O  OE2 . GLU B 1 219 ? -0.20551  26.75033  12.15285  1.000 34.19216 -1 219 GLU B OE2 1 
ATOM   3526 N  N   . HIS B 1 220 ? 4.43389   23.44987  11.27391  1.000 23.58757 ?  220 HIS B N   1 
ATOM   3527 C  CA  . HIS B 1 220 ? 4.34165   22.04237  11.66230  1.000 17.83911 ?  220 HIS B CA  1 
ATOM   3528 C  C   . HIS B 1 220 ? 5.53975   21.62584  12.50222  1.000 16.38976 ?  220 HIS B C   1 
ATOM   3529 O  O   . HIS B 1 220 ? 5.38294   20.98757  13.55107  1.000 20.07718 ?  220 HIS B O   1 
ATOM   3530 C  CB  . HIS B 1 220 ? 4.24763   21.13060  10.44708  1.000 15.89545 ?  220 HIS B CB  1 
ATOM   3531 C  CG  . HIS B 1 220 ? 4.62435   19.71853  10.76186  1.000 17.20131 ?  220 HIS B CG  1 
ATOM   3532 N  ND1 . HIS B 1 220 ? 3.75221   18.83488  11.35843  1.000 16.59784 ?  220 HIS B ND1 1 
ATOM   3533 C  CD2 . HIS B 1 220 ? 5.80103   19.05923  10.63169  1.000 15.64181 ?  220 HIS B CD2 1 
ATOM   3534 C  CE1 . HIS B 1 220 ? 4.36440   17.67973  11.54901  1.000 14.74821 ?  220 HIS B CE1 1 
ATOM   3535 N  NE2 . HIS B 1 220 ? 5.61139   17.79228  11.12360  1.000 15.21308 ?  220 HIS B NE2 1 
ATOM   3536 N  N   . ASP B 1 221 ? 6.75153   21.94291  12.03011  1.000 14.42489 ?  221 ASP B N   1 
ATOM   3537 C  CA  . ASP B 1 221 ? 7.95262   21.57984  12.77677  1.000 18.60726 ?  221 ASP B CA  1 
ATOM   3538 C  C   . ASP B 1 221 ? 7.88270   22.11469  14.19600  1.000 21.24089 ?  221 ASP B C   1 
ATOM   3539 O  O   . ASP B 1 221 ? 8.07524   21.36710  15.16065  1.000 16.88776 ?  221 ASP B O   1 
ATOM   3540 C  CB  . ASP B 1 221 ? 9.20556   22.10955  12.08079  1.000 17.68635 ?  221 ASP B CB  1 
ATOM   3541 C  CG  . ASP B 1 221 ? 9.49481   21.41044  10.78210  1.000 19.04270 ?  221 ASP B CG  1 
ATOM   3542 O  OD1 . ASP B 1 221 ? 8.88115   20.35109  10.50730  1.000 17.85188 ?  221 ASP B OD1 1 
ATOM   3543 O  OD2 . ASP B 1 221 ? 10.33546  21.92825  10.02633  1.000 19.33200 -1 221 ASP B OD2 1 
ATOM   3544 N  N   . ALA B 1 222 ? 7.57580   23.40987  14.34065  1.000 19.93421 ?  222 ALA B N   1 
ATOM   3545 C  CA  . ALA B 1 222 ? 7.48027   24.00579  15.66808  1.000 21.05775 ?  222 ALA B CA  1 
ATOM   3546 C  C   . ALA B 1 222 ? 6.51401   23.22973  16.55133  1.000 18.21084 ?  222 ALA B C   1 
ATOM   3547 O  O   . ALA B 1 222 ? 6.81412   22.95273  17.71780  1.000 21.60872 ?  222 ALA B O   1 
ATOM   3548 C  CB  . ALA B 1 222 ? 7.04746   25.46822  15.55833  1.000 23.16287 ?  222 ALA B CB  1 
ATOM   3549 N  N   . ALA B 1 223 ? 5.34841   22.86560  16.01055  1.000 17.19593 ?  223 ALA B N   1 
ATOM   3550 C  CA  . ALA B 1 223 ? 4.37381   22.10905  16.78913  1.000 18.04870 ?  223 ALA B CA  1 
ATOM   3551 C  C   . ALA B 1 223 ? 4.90065   20.71849  17.13329  1.000 17.79270 ?  223 ALA B C   1 
ATOM   3552 O  O   . ALA B 1 223 ? 4.78068   20.26013  18.27497  1.000 16.71660 ?  223 ALA B O   1 
ATOM   3553 C  CB  . ALA B 1 223 ? 3.05119   22.01085  16.02204  1.000 18.98308 ?  223 ALA B CB  1 
ATOM   3554 N  N   . ALA B 1 224 ? 5.50522   20.03655  16.16484  1.000 18.45817 ?  224 ALA B N   1 
ATOM   3555 C  CA  . ALA B 1 224 ? 5.92528   18.66282  16.41888  1.000 19.47277 ?  224 ALA B CA  1 
ATOM   3556 C  C   . ALA B 1 224 ? 7.05863   18.61325  17.43901  1.000 20.18617 ?  224 ALA B C   1 
ATOM   3557 O  O   . ALA B 1 224 ? 7.12401   17.69081  18.26190  1.000 24.23194 ?  224 ALA B O   1 
ATOM   3558 C  CB  . ALA B 1 224 ? 6.33241   17.98835  15.10516  1.000 14.04171 ?  224 ALA B CB  1 
ATOM   3559 N  N   . LEU B 1 225 ? 7.94014   19.61163  17.41968  1.000 21.63355 ?  225 LEU B N   1 
ATOM   3560 C  CA  . LEU B 1 225 ? 9.08508   19.68795  18.32258  1.000 25.04590 ?  225 LEU B CA  1 
ATOM   3561 C  C   . LEU B 1 225 ? 8.76469   20.34083  19.66184  1.000 25.66161 ?  225 LEU B C   1 
ATOM   3562 O  O   . LEU B 1 225 ? 9.64133   20.36180  20.53157  1.000 27.73186 ?  225 LEU B O   1 
ATOM   3563 C  CB  . LEU B 1 225 ? 10.22661  20.46615  17.65852  1.000 19.37243 ?  225 LEU B CB  1 
ATOM   3564 C  CG  . LEU B 1 225 ? 10.59141  19.94465  16.25947  1.000 28.48850 ?  225 LEU B CG  1 
ATOM   3565 C  CD1 . LEU B 1 225 ? 11.67592  20.76679  15.59109  1.000 25.24186 ?  225 LEU B CD1 1 
ATOM   3566 C  CD2 . LEU B 1 225 ? 11.00095  18.49657  16.33421  1.000 19.80663 ?  225 LEU B CD2 1 
ATOM   3567 N  N   . GLU B 1 226 ? 7.55749   20.88042  19.83787  1.000 23.87847 ?  226 GLU B N   1 
ATOM   3568 C  CA  . GLU B 1 226 ? 7.13567   21.55562  21.07657  1.000 27.29767 ?  226 GLU B CA  1 
ATOM   3569 C  C   . GLU B 1 226 ? 8.08473   22.67278  21.50175  1.000 30.36451 ?  226 GLU B C   1 
ATOM   3570 O  O   . GLU B 1 226 ? 8.19090   23.70636  20.83331  1.000 43.62879 ?  226 GLU B O   1 
ATOM   3571 C  CB  . GLU B 1 226 ? 6.99794   20.54458  22.22229  1.000 25.72398 ?  226 GLU B CB  1 
ATOM   3572 C  CG  . GLU B 1 226 ? 6.02531   19.42709  21.92628  1.000 31.93207 ?  226 GLU B CG  1 
ATOM   3573 C  CD  . GLU B 1 226 ? 6.00670   18.37398  23.01458  1.000 42.97286 ?  226 GLU B CD  1 
ATOM   3574 O  OE1 . GLU B 1 226 ? 5.37294   18.61752  24.06176  1.000 50.81919 ?  226 GLU B OE1 1 
ATOM   3575 O  OE2 . GLU B 1 226 ? 6.63484   17.30771  22.82736  1.000 38.21279 -1 226 GLU B OE2 1 
HETATM 3576 C  C   . ACY C 2 .   ? 16.98760  -5.15301  34.13178  1.000 12.45519 ?  301 ACY A C   1 
HETATM 3577 O  O   . ACY C 2 .   ? 15.93500  -5.80286  34.00815  1.000 9.09514  ?  301 ACY A O   1 
HETATM 3578 O  OXT . ACY C 2 .   ? 18.13754  -5.61487  34.32656  1.000 8.16904  ?  301 ACY A OXT 1 
HETATM 3579 C  CH3 . ACY C 2 .   ? 16.83694  -3.61894  33.97764  1.000 13.05997 ?  301 ACY A CH3 1 
HETATM 3580 C  C   . ACY D 2 .   ? 18.51229  -0.74064  30.27161  1.000 22.79293 ?  302 ACY A C   1 
HETATM 3581 O  O   . ACY D 2 .   ? 18.04077  -1.47104  29.35979  1.000 27.61505 ?  302 ACY A O   1 
HETATM 3582 O  OXT . ACY D 2 .   ? 19.31663  0.20459   30.13703  1.000 17.07513 ?  302 ACY A OXT 1 
HETATM 3583 C  CH3 . ACY D 2 .   ? 18.07695  -1.00737  31.72985  1.000 20.60265 ?  302 ACY A CH3 1 
HETATM 3584 C  C   . ACY E 2 .   ? 17.63185  6.42279   34.06995  1.000 11.26145 ?  303 ACY A C   1 
HETATM 3585 O  O   . ACY E 2 .   ? 18.28754  6.66460   33.02665  1.000 10.82295 ?  303 ACY A O   1 
HETATM 3586 O  OXT . ACY E 2 .   ? 17.52980  7.15372   35.08494  1.000 9.38020  ?  303 ACY A OXT 1 
HETATM 3587 C  CH3 . ACY E 2 .   ? 16.87733  5.06239   34.13941  1.000 10.59405 ?  303 ACY A CH3 1 
HETATM 3588 MG MG  . MG  F 3 .   ? 13.78007  -5.24789  32.67164  1.000 17.32594 ?  304 MG  A MG  1 
HETATM 3589 MG MG  . MG  G 3 .   ? 16.24725  -3.25826  29.50045  1.000 29.67200 ?  305 MG  A MG  1 
HETATM 3590 MG MG  . MG  H 3 .   ? 18.82116  5.02439   31.01062  1.000 21.08892 ?  306 MG  A MG  1 
HETATM 3591 MG MG  . MG  I 3 .   ? 15.42804  2.29072   21.60254  1.000 14.60113 ?  307 MG  A MG  1 
HETATM 3592 C  C1  . EDO J 4 .   ? 5.15712   -5.15332  -7.19704  1.000 35.40420 ?  301 EDO B C1  1 
HETATM 3593 O  O1  . EDO J 4 .   ? 3.80528   -4.85163  -6.97184  1.000 37.92582 ?  301 EDO B O1  1 
HETATM 3594 C  C2  . EDO J 4 .   ? 5.84899   -5.32117  -5.87493  1.000 26.30279 ?  301 EDO B C2  1 
HETATM 3595 O  O2  . EDO J 4 .   ? 7.23166   -5.48900  -6.05830  1.000 31.22789 ?  301 EDO B O2  1 
HETATM 3596 C  C   . ACY K 2 .   ? 4.98749   -1.52787  8.61605   1.000 13.47623 ?  302 ACY B C   1 
HETATM 3597 O  O   . ACY K 2 .   ? 6.22257   -1.76419  8.59900   1.000 13.01738 ?  302 ACY B O   1 
HETATM 3598 O  OXT . ACY K 2 .   ? 4.06983   -2.25444  8.16574   1.000 13.93334 ?  302 ACY B OXT 1 
HETATM 3599 C  CH3 . ACY K 2 .   ? 4.52283   -0.18158  9.25014   1.000 17.61128 ?  302 ACY B CH3 1 
HETATM 3600 C  C   . ACY L 2 .   ? 4.43258   10.07193  9.11146   1.000 14.91451 ?  303 ACY B C   1 
HETATM 3601 O  O   . ACY L 2 .   ? 3.99412   10.68440  10.10509  1.000 12.87996 ?  303 ACY B O   1 
HETATM 3602 O  OXT . ACY L 2 .   ? 5.00929   10.57216  8.12023   1.000 11.96624 ?  303 ACY B OXT 1 
HETATM 3603 C  CH3 . ACY L 2 .   ? 4.25262   8.53655   9.10524   1.000 14.91039 ?  303 ACY B CH3 1 
HETATM 3604 C  C   . ACY M 2 .   ? 8.79651   5.59004   10.21814  1.000 23.99421 ?  304 ACY B C   1 
HETATM 3605 O  O   . ACY M 2 .   ? 9.28194   6.31970   11.11495  1.000 27.15110 ?  304 ACY B O   1 
HETATM 3606 O  OXT . ACY M 2 .   ? 9.39240   4.71972   9.54786   1.000 24.20046 ?  304 ACY B OXT 1 
HETATM 3607 C  CH3 . ACY M 2 .   ? 7.29928   5.76567   9.89328   1.000 22.77693 ?  304 ACY B CH3 1 
HETATM 3608 MG MG  . MG  N 3 .   ? 8.19831   -0.25883  9.59496   1.000 22.44884 ?  305 MG  B MG  1 
HETATM 3609 MG MG  . MG  O 3 .   ? 3.83848   10.12182  12.51178  1.000 22.92609 ?  306 MG  B MG  1 
HETATM 3610 MG MG  . MG  P 3 .   ? 15.01875  -1.13585  17.43266  1.000 31.36247 ?  307 MG  B MG  1 
HETATM 3611 MG MG  . MG  Q 3 .   ? 11.75114  5.15436   10.58401  1.000 29.96362 ?  308 MG  B MG  1 
HETATM 3612 O  O   . HOH R 5 .   ? 15.21760  -18.39860 52.62224  1.000 33.46774 ?  401 HOH A O   1 
HETATM 3613 O  O   . HOH R 5 .   ? 15.64936  -1.09159  21.34210  1.000 29.97639 ?  402 HOH A O   1 
HETATM 3614 O  O   . HOH R 5 .   ? 28.40433  -6.94618  53.24232  1.000 33.63196 ?  403 HOH A O   1 
HETATM 3615 O  O   . HOH R 5 .   ? 28.21876  -2.06432  17.64631  1.000 40.94561 ?  404 HOH A O   1 
HETATM 3616 O  O   . HOH R 5 .   ? 34.17747  -6.58581  21.94922  1.000 26.13754 ?  405 HOH A O   1 
HETATM 3617 O  O   . HOH R 5 .   ? 26.31901  -6.49075  21.07569  1.000 29.00511 ?  406 HOH A O   1 
HETATM 3618 O  O   . HOH R 5 .   ? 21.85259  -25.83702 29.78835  1.000 39.69242 ?  407 HOH A O   1 
HETATM 3619 O  O   . HOH R 5 .   ? 26.96185  -11.80028 26.19670  1.000 21.09981 ?  408 HOH A O   1 
HETATM 3620 O  O   . HOH R 5 .   ? 12.39771  -9.77745  41.06825  1.000 12.92149 ?  409 HOH A O   1 
HETATM 3621 O  O   . HOH R 5 .   ? 32.88602  -14.67708 40.08302  1.000 27.73461 ?  410 HOH A O   1 
HETATM 3622 O  O   . HOH R 5 .   ? 11.97398  16.35716  43.46612  1.000 27.15858 ?  411 HOH A O   1 
HETATM 3623 O  O   . HOH R 5 .   ? 28.893    -19.443   45.590    1.000 22.84963 ?  412 HOH A O   1 
HETATM 3624 O  O   . HOH R 5 .   ? 29.10508  15.21539  37.31601  1.000 32.33625 ?  413 HOH A O   1 
HETATM 3625 O  O   . HOH R 5 .   ? 8.92650   6.98312   49.58893  1.000 24.83191 ?  414 HOH A O   1 
HETATM 3626 O  O   . HOH R 5 .   ? 38.81427  8.50682   30.05501  1.000 29.37081 ?  415 HOH A O   1 
HETATM 3627 O  O   . HOH R 5 .   ? 20.60252  13.52722  47.78415  1.000 27.86242 ?  416 HOH A O   1 
HETATM 3628 O  O   . HOH R 5 .   ? 9.32797   -13.63686 39.55870  1.000 35.04008 ?  417 HOH A O   1 
HETATM 3629 O  O   . HOH R 5 .   ? 24.58838  -20.55978 43.45810  1.000 17.71474 ?  418 HOH A O   1 
HETATM 3630 O  O   . HOH R 5 .   ? 12.43588  -14.61837 34.91204  1.000 15.36463 ?  419 HOH A O   1 
HETATM 3631 O  O   . HOH R 5 .   ? 14.39516  -17.40606 37.52910  1.000 23.64041 ?  420 HOH A O   1 
HETATM 3632 O  O   . HOH R 5 .   ? 13.79624  9.50216   28.13918  1.000 8.20169  ?  421 HOH A O   1 
HETATM 3633 O  O   . HOH R 5 .   ? 4.88526   -3.16546  46.25757  1.000 28.65065 ?  422 HOH A O   1 
HETATM 3634 O  O   . HOH R 5 .   ? 8.85042   -4.63346  45.49093  1.000 13.31217 ?  423 HOH A O   1 
HETATM 3635 O  O   . HOH R 5 .   ? 15.89967  7.47119   37.27553  1.000 5.50780  ?  424 HOH A O   1 
HETATM 3636 O  O   . HOH R 5 .   ? 5.45769   13.60114  45.67893  1.000 28.72924 ?  425 HOH A O   1 
HETATM 3637 O  O   . HOH R 5 .   ? 12.11010  9.70998   24.95584  1.000 26.92767 ?  426 HOH A O   1 
HETATM 3638 O  O   . HOH R 5 .   ? 26.07087  -11.65310 32.72392  1.000 12.80560 ?  427 HOH A O   1 
HETATM 3639 O  O   . HOH R 5 .   ? 7.38086   -15.68661 29.13935  1.000 28.43852 ?  428 HOH A O   1 
HETATM 3640 O  O   . HOH R 5 .   ? 13.03744  -1.90000  51.46708  1.000 31.78108 ?  429 HOH A O   1 
HETATM 3641 O  O   . HOH R 5 .   ? 19.83871  17.42622  33.99909  1.000 10.92132 ?  430 HOH A O   1 
HETATM 3642 O  O   . HOH R 5 .   ? 28.79421  -17.54787 30.63307  1.000 23.46133 ?  431 HOH A O   1 
HETATM 3643 O  O   . HOH R 5 .   ? 40.32264  -0.39893  37.37458  1.000 26.45469 ?  432 HOH A O   1 
HETATM 3644 O  O   . HOH R 5 .   ? 24.70715  14.27495  46.76380  1.000 26.67463 ?  433 HOH A O   1 
HETATM 3645 O  O   . HOH R 5 .   ? 27.25658  -13.71150 46.55906  1.000 26.79169 ?  434 HOH A O   1 
HETATM 3646 O  O   . HOH R 5 .   ? 17.28985  -20.01579 41.22567  1.000 17.24164 ?  435 HOH A O   1 
HETATM 3647 O  O   . HOH R 5 .   ? 33.38589  -0.69362  33.30564  1.000 10.45417 ?  436 HOH A O   1 
HETATM 3648 O  O   . HOH R 5 .   ? 24.13163  4.17832   53.11940  1.000 36.67753 ?  437 HOH A O   1 
HETATM 3649 O  O   . HOH R 5 .   ? 17.12925  11.77347  37.20232  1.000 7.75601  ?  438 HOH A O   1 
HETATM 3650 O  O   . HOH R 5 .   ? 33.13977  -7.10901  40.63632  1.000 25.51583 ?  439 HOH A O   1 
HETATM 3651 O  O   . HOH R 5 .   ? 1.47982   0.59733   44.36107  1.000 22.13958 ?  440 HOH A O   1 
HETATM 3652 O  O   . HOH R 5 .   ? 40.09194  9.21168   37.88443  1.000 24.08738 ?  441 HOH A O   1 
HETATM 3653 O  O   . HOH R 5 .   ? 19.76358  17.69660  23.21053  1.000 11.69444 ?  442 HOH A O   1 
HETATM 3654 O  O   . HOH R 5 .   ? 21.48822  1.44427   19.30940  1.000 13.45132 ?  443 HOH A O   1 
HETATM 3655 O  O   . HOH R 5 .   ? 33.35174  -10.45556 59.29965  1.000 43.29689 ?  444 HOH A O   1 
HETATM 3656 O  O   . HOH R 5 .   ? 13.03840  -18.47631 48.72163  1.000 32.45346 ?  445 HOH A O   1 
HETATM 3657 O  O   . HOH R 5 .   ? 12.41191  -10.96597 43.72244  1.000 12.83147 ?  446 HOH A O   1 
HETATM 3658 O  O   . HOH R 5 .   ? 21.78488  -12.80535 31.63396  1.000 12.18090 ?  447 HOH A O   1 
HETATM 3659 O  O   . HOH R 5 .   ? 28.70428  -3.92345  25.93231  1.000 19.11753 ?  448 HOH A O   1 
HETATM 3660 O  O   . HOH R 5 .   ? 26.78321  -14.22409 23.59988  1.000 27.80307 ?  449 HOH A O   1 
HETATM 3661 O  O   . HOH R 5 .   ? -3.00807  5.47428   32.86829  1.000 23.03814 ?  450 HOH A O   1 
HETATM 3662 O  O   . HOH R 5 .   ? 16.37295  -16.81663 46.89022  1.000 12.33856 ?  451 HOH A O   1 
HETATM 3663 O  O   . HOH R 5 .   ? 20.16456  -0.25184  27.41016  1.000 19.24594 ?  452 HOH A O   1 
HETATM 3664 O  O   . HOH R 5 .   ? 20.22994  6.56913   25.43077  1.000 9.36436  ?  453 HOH A O   1 
HETATM 3665 O  O   . HOH R 5 .   ? 30.14973  20.05373  25.11224  1.000 27.62359 ?  454 HOH A O   1 
HETATM 3666 O  O   . HOH R 5 .   ? 1.75229   4.02814   36.23930  1.000 21.96793 ?  455 HOH A O   1 
HETATM 3667 O  O   . HOH R 5 .   ? 6.66651   -8.05746  46.34882  1.000 26.79165 ?  456 HOH A O   1 
HETATM 3668 O  O   . HOH R 5 .   ? 14.82003  1.70763   32.05212  1.000 29.69744 ?  457 HOH A O   1 
HETATM 3669 O  O   . HOH R 5 .   ? 22.38870  -9.56272  18.58929  1.000 16.37085 ?  458 HOH A O   1 
HETATM 3670 O  O   . HOH R 5 .   ? 1.53671   -0.27915  36.89884  1.000 28.57872 ?  459 HOH A O   1 
HETATM 3671 O  O   . HOH R 5 .   ? 19.74095  -19.03943 27.03811  1.000 28.86267 ?  460 HOH A O   1 
HETATM 3672 O  O   . HOH R 5 .   ? 29.63488  1.26429   50.34421  1.000 25.92836 ?  461 HOH A O   1 
HETATM 3673 O  O   . HOH R 5 .   ? 11.50417  -20.89609 31.40861  1.000 25.25853 ?  462 HOH A O   1 
HETATM 3674 O  O   . HOH R 5 .   ? 32.08872  9.72039   33.97111  1.000 12.10437 ?  463 HOH A O   1 
HETATM 3675 O  O   . HOH R 5 .   ? 31.88647  -13.22280 35.17843  1.000 20.98312 ?  464 HOH A O   1 
HETATM 3676 O  O   . HOH R 5 .   ? 9.04679   -12.04462 45.47562  1.000 22.38700 ?  465 HOH A O   1 
HETATM 3677 O  O   . HOH R 5 .   ? 19.16554  3.43126   14.59510  1.000 15.53763 ?  466 HOH A O   1 
HETATM 3678 O  O   . HOH R 5 .   ? 13.89532  10.20451  49.44534  1.000 14.63485 ?  467 HOH A O   1 
HETATM 3679 O  O   . HOH R 5 .   ? 2.08684   14.33645  43.79269  1.000 29.45953 ?  468 HOH A O   1 
HETATM 3680 O  O   . HOH R 5 .   ? 35.05071  0.47473   43.20781  1.000 16.67406 ?  469 HOH A O   1 
HETATM 3681 O  O   . HOH R 5 .   ? -3.53983  2.82295   41.12520  1.000 23.31649 ?  470 HOH A O   1 
HETATM 3682 O  O   . HOH R 5 .   ? 24.94231  16.54131  38.30140  1.000 10.33272 ?  471 HOH A O   1 
HETATM 3683 O  O   . HOH R 5 .   ? 38.895    -1.266    28.256    1.000 31.42342 ?  472 HOH A O   1 
HETATM 3684 O  O   . HOH R 5 .   ? 9.29809   0.69730   38.47112  1.000 9.84306  ?  473 HOH A O   1 
HETATM 3685 O  O   . HOH R 5 .   ? 2.42714   15.24997  38.38803  1.000 32.98122 ?  474 HOH A O   1 
HETATM 3686 O  O   . HOH R 5 .   ? 33.96010  11.85079  28.71076  1.000 25.67972 ?  475 HOH A O   1 
HETATM 3687 O  O   . HOH R 5 .   ? 15.89355  -3.43540  20.61240  1.000 18.13472 ?  476 HOH A O   1 
HETATM 3688 O  O   . HOH R 5 .   ? 15.13032  1.42246   34.94410  1.000 12.85463 ?  477 HOH A O   1 
HETATM 3689 O  O   . HOH R 5 .   ? 22.65283  3.41979   21.50349  1.000 8.52286  ?  478 HOH A O   1 
HETATM 3690 O  O   . HOH R 5 .   ? 9.28328   -11.11072 26.13314  1.000 14.73980 ?  479 HOH A O   1 
HETATM 3691 O  O   . HOH R 5 .   ? 8.90813   -6.36512  47.71130  1.000 22.68351 ?  480 HOH A O   1 
HETATM 3692 O  O   . HOH R 5 .   ? 18.57073  -10.67779 32.84522  1.000 14.92678 ?  481 HOH A O   1 
HETATM 3693 O  O   . HOH R 5 .   ? 34.44403  0.41991   30.86858  1.000 11.41597 ?  482 HOH A O   1 
HETATM 3694 O  O   . HOH R 5 .   ? 13.95919  16.36135  28.65851  1.000 12.08787 ?  483 HOH A O   1 
HETATM 3695 O  O   . HOH R 5 .   ? 27.09928  16.48657  42.26367  1.000 15.21040 ?  484 HOH A O   1 
HETATM 3696 O  O   . HOH R 5 .   ? 17.20872  -19.28023 34.91877  1.000 20.20060 ?  485 HOH A O   1 
HETATM 3697 O  O   . HOH R 5 .   ? 21.79464  -15.09929 28.30048  1.000 12.07419 ?  486 HOH A O   1 
HETATM 3698 O  O   . HOH R 5 .   ? 0.57667   4.86891   34.08559  1.000 29.50912 ?  487 HOH A O   1 
HETATM 3699 O  O   . HOH R 5 .   ? 12.68097  -1.18621  30.82676  1.000 30.08522 ?  488 HOH A O   1 
HETATM 3700 O  O   . HOH R 5 .   ? 19.66646  13.18124  35.79115  1.000 8.74390  ?  489 HOH A O   1 
HETATM 3701 O  O   . HOH R 5 .   ? 27.11168  13.97366  23.12993  1.000 22.52866 ?  490 HOH A O   1 
HETATM 3702 O  O   . HOH R 5 .   ? 21.34637  5.72357   30.11077  1.000 8.13485  ?  491 HOH A O   1 
HETATM 3703 O  O   . HOH R 5 .   ? 29.85060  14.86346  26.29862  1.000 23.44063 ?  492 HOH A O   1 
HETATM 3704 O  O   . HOH R 5 .   ? 38.92332  3.41106   34.51990  1.000 14.43752 ?  493 HOH A O   1 
HETATM 3705 O  O   . HOH R 5 .   ? 25.99313  9.11982   20.74539  1.000 18.43013 ?  494 HOH A O   1 
HETATM 3706 O  O   . HOH R 5 .   ? 11.59826  13.27157  27.44754  1.000 12.83389 ?  495 HOH A O   1 
HETATM 3707 O  O   . HOH R 5 .   ? 32.77611  11.65395  32.05314  1.000 26.47774 ?  496 HOH A O   1 
HETATM 3708 O  O   . HOH R 5 .   ? 22.29768  12.40221  21.41413  1.000 13.45428 ?  497 HOH A O   1 
HETATM 3709 O  O   . HOH R 5 .   ? 5.72068   0.99210   28.84678  1.000 28.86608 ?  498 HOH A O   1 
HETATM 3710 O  O   . HOH R 5 .   ? 16.01046  -19.52462 37.46382  1.000 27.91957 ?  499 HOH A O   1 
HETATM 3711 O  O   . HOH R 5 .   ? 17.92465  -9.23678  38.84582  1.000 11.47918 ?  500 HOH A O   1 
HETATM 3712 O  O   . HOH R 5 .   ? 24.188    20.932    33.166    1.000 23.31288 ?  501 HOH A O   1 
HETATM 3713 O  O   . HOH R 5 .   ? 15.54259  -8.57958  25.93964  1.000 11.16726 ?  502 HOH A O   1 
HETATM 3714 O  O   . HOH R 5 .   ? 29.93128  -9.82684  33.40499  1.000 11.21774 ?  503 HOH A O   1 
HETATM 3715 O  O   . HOH R 5 .   ? 30.45164  10.55692  41.12227  1.000 21.76641 ?  504 HOH A O   1 
HETATM 3716 O  O   . HOH R 5 .   ? 30.74998  -3.85303  39.14094  1.000 12.28626 ?  505 HOH A O   1 
HETATM 3717 O  O   . HOH R 5 .   ? 1.27939   8.60066   40.02758  1.000 14.96869 ?  506 HOH A O   1 
HETATM 3718 O  O   . HOH R 5 .   ? 36.32227  -0.44035  40.66832  1.000 18.87778 ?  507 HOH A O   1 
HETATM 3719 O  O   . HOH R 5 .   ? 16.55282  -9.53830  56.77098  1.000 26.02267 ?  508 HOH A O   1 
HETATM 3720 O  O   . HOH R 5 .   ? 32.23143  -14.97443 32.31705  1.000 23.53352 ?  509 HOH A O   1 
HETATM 3721 O  O   . HOH R 5 .   ? 9.29443   -10.54438 36.65729  1.000 25.46575 ?  510 HOH A O   1 
HETATM 3722 O  O   . HOH R 5 .   ? 28.44959  -2.50394  20.34025  1.000 31.26294 ?  511 HOH A O   1 
HETATM 3723 O  O   . HOH R 5 .   ? 20.76000  -15.51417 31.50938  1.000 11.23449 ?  512 HOH A O   1 
HETATM 3724 O  O   . HOH R 5 .   ? 16.25754  20.20716  32.99280  1.000 23.40995 ?  513 HOH A O   1 
HETATM 3725 O  O   . HOH R 5 .   ? 26.16191  -19.54356 34.10220  1.000 27.37424 ?  514 HOH A O   1 
HETATM 3726 O  O   . HOH R 5 .   ? 21.36809  -21.95130 33.10641  1.000 26.21228 ?  515 HOH A O   1 
HETATM 3727 O  O   . HOH R 5 .   ? 36.33370  -4.53430  38.99620  1.000 28.44547 ?  516 HOH A O   1 
HETATM 3728 O  O   . HOH R 5 .   ? 25.18331  -3.11398  52.57833  1.000 28.29766 ?  517 HOH A O   1 
HETATM 3729 O  O   . HOH R 5 .   ? 27.36552  19.94050  18.64763  1.000 27.20184 ?  518 HOH A O   1 
HETATM 3730 O  O   . HOH R 5 .   ? 16.92456  11.29816  20.21028  1.000 17.16021 ?  519 HOH A O   1 
HETATM 3731 O  O   . HOH R 5 .   ? 5.64859   15.05432  39.72208  1.000 28.50273 ?  520 HOH A O   1 
HETATM 3732 O  O   . HOH R 5 .   ? 30.70545  -3.78913  49.42767  1.000 29.75781 ?  521 HOH A O   1 
HETATM 3733 O  O   . HOH R 5 .   ? 31.12448  5.42467   26.12568  1.000 16.18189 ?  522 HOH A O   1 
HETATM 3734 O  O   . HOH R 5 .   ? 18.51165  -15.77760 19.90278  1.000 34.70199 ?  523 HOH A O   1 
HETATM 3735 O  O   . HOH R 5 .   ? 28.01853  -11.42536 34.88469  1.000 11.84124 ?  524 HOH A O   1 
HETATM 3736 O  O   . HOH R 5 .   ? 27.84948  -3.21069  23.19867  1.000 31.21380 ?  525 HOH A O   1 
HETATM 3737 O  O   . HOH R 5 .   ? 25.76293  -9.57411  28.10337  1.000 16.57264 ?  526 HOH A O   1 
HETATM 3738 O  O   . HOH R 5 .   ? 10.27664  -16.48202 20.72231  1.000 40.70162 ?  527 HOH A O   1 
HETATM 3739 O  O   . HOH R 5 .   ? 5.46210   0.89927   47.55577  1.000 27.14928 ?  528 HOH A O   1 
HETATM 3740 O  O   . HOH R 5 .   ? 17.47838  15.63771  44.97893  1.000 29.96602 ?  529 HOH A O   1 
HETATM 3741 O  O   . HOH R 5 .   ? 13.05658  17.29239  32.49740  1.000 25.16526 ?  530 HOH A O   1 
HETATM 3742 O  O   . HOH R 5 .   ? 4.67987   5.77168   28.79692  1.000 20.52576 ?  531 HOH A O   1 
HETATM 3743 O  O   . HOH R 5 .   ? 24.64670  22.69877  18.08085  1.000 33.82015 ?  532 HOH A O   1 
HETATM 3744 O  O   . HOH R 5 .   ? 22.85750  7.99176   16.27705  1.000 26.96378 ?  533 HOH A O   1 
HETATM 3745 O  O   . HOH R 5 .   ? 11.22313  -7.39690  50.34989  1.000 28.94729 ?  534 HOH A O   1 
HETATM 3746 O  O   . HOH R 5 .   ? 22.20053  8.02336   31.44679  1.000 7.01424  ?  535 HOH A O   1 
HETATM 3747 O  O   . HOH R 5 .   ? 6.84487   8.28985   28.92845  1.000 32.01432 ?  536 HOH A O   1 
HETATM 3748 O  O   . HOH R 5 .   ? 8.59415   -5.11590  38.71180  1.000 10.24265 ?  537 HOH A O   1 
HETATM 3749 O  O   . HOH R 5 .   ? 12.97641  -1.64119  19.30861  1.000 25.73380 ?  538 HOH A O   1 
HETATM 3750 O  O   . HOH R 5 .   ? 17.63244  -20.59819 27.41961  1.000 30.17688 ?  539 HOH A O   1 
HETATM 3751 O  O   . HOH R 5 .   ? 34.76399  -6.11561  39.82344  1.000 29.56385 ?  540 HOH A O   1 
HETATM 3752 O  O   . HOH R 5 .   ? 21.20743  -11.32342 19.64309  1.000 35.53848 ?  541 HOH A O   1 
HETATM 3753 O  O   . HOH R 5 .   ? 35.98865  7.92570   39.49284  1.000 14.82619 ?  542 HOH A O   1 
HETATM 3754 O  O   . HOH R 5 .   ? 24.41753  15.49304  44.33451  1.000 12.06663 ?  543 HOH A O   1 
HETATM 3755 O  O   . HOH R 5 .   ? 24.46823  -15.82264 27.03532  1.000 20.19082 ?  544 HOH A O   1 
HETATM 3756 O  O   . HOH R 5 .   ? 27.04692  5.93097   18.37764  1.000 24.31714 ?  545 HOH A O   1 
HETATM 3757 O  O   . HOH R 5 .   ? 8.94790   -9.08409  40.05224  1.000 24.39876 ?  546 HOH A O   1 
HETATM 3758 O  O   . HOH R 5 .   ? 9.75057   8.98989   28.97754  1.000 26.44167 ?  547 HOH A O   1 
HETATM 3759 O  O   . HOH R 5 .   ? 15.58697  3.75951   55.88332  1.000 35.22303 ?  548 HOH A O   1 
HETATM 3760 O  O   . HOH R 5 .   ? 24.05957  -14.51082 21.40422  1.000 27.41781 ?  549 HOH A O   1 
HETATM 3761 O  O   . HOH R 5 .   ? 28.22418  -14.52464 27.23297  1.000 26.50521 ?  550 HOH A O   1 
HETATM 3762 O  O   . HOH R 5 .   ? 33.22923  -11.84203 41.83069  1.000 25.09977 ?  551 HOH A O   1 
HETATM 3763 O  O   . HOH R 5 .   ? 16.57766  5.92998   20.89644  1.000 21.42863 ?  552 HOH A O   1 
HETATM 3764 O  O   . HOH R 5 .   ? 3.80907   -4.62269  39.27490  1.000 24.04207 ?  553 HOH A O   1 
HETATM 3765 O  O   . HOH R 5 .   ? 8.31196   -15.91618 33.92387  1.000 23.82665 ?  554 HOH A O   1 
HETATM 3766 O  O   . HOH R 5 .   ? 30.225    17.896    35.831    1.000 39.44767 ?  555 HOH A O   1 
HETATM 3767 O  O   . HOH R 5 .   ? 7.05272   -10.55049 27.72670  1.000 17.68107 ?  556 HOH A O   1 
HETATM 3768 O  O   . HOH R 5 .   ? 19.94524  -6.16117  54.94036  1.000 30.69277 ?  557 HOH A O   1 
HETATM 3769 O  O   . HOH R 5 .   ? 29.69799  22.78375  24.45868  1.000 27.14660 ?  558 HOH A O   1 
HETATM 3770 O  O   . HOH R 5 .   ? 21.78250  -15.68751 25.83642  1.000 31.20267 ?  559 HOH A O   1 
HETATM 3771 O  O   . HOH R 5 .   ? 15.92469  2.11976   28.79878  1.000 22.13306 ?  560 HOH A O   1 
HETATM 3772 O  O   . HOH R 5 .   ? 21.78126  12.56912  15.32767  1.000 23.39471 ?  561 HOH A O   1 
HETATM 3773 O  O   . HOH R 5 .   ? 28.97863  -16.51441 55.89046  1.000 37.33499 ?  562 HOH A O   1 
HETATM 3774 O  O   . HOH R 5 .   ? 26.46154  -19.35293 31.47476  1.000 24.36878 ?  563 HOH A O   1 
HETATM 3775 O  O   . HOH R 5 .   ? 29.49077  -10.93289 25.32443  1.000 25.07294 ?  564 HOH A O   1 
HETATM 3776 O  O   . HOH R 5 .   ? 18.22464  -19.00864 52.90710  1.000 19.18763 ?  565 HOH A O   1 
HETATM 3777 O  O   . HOH R 5 .   ? 33.82246  2.86370   44.35461  1.000 17.83810 ?  566 HOH A O   1 
HETATM 3778 O  O   . HOH R 5 .   ? 26.31842  17.96973  36.41139  1.000 18.19397 ?  567 HOH A O   1 
HETATM 3779 O  O   . HOH R 5 .   ? 6.03079   -2.34031  32.50468  1.000 18.14415 ?  568 HOH A O   1 
HETATM 3780 O  O   . HOH R 5 .   ? 19.63640  22.87244  19.91761  1.000 39.30969 ?  569 HOH A O   1 
HETATM 3781 O  O   . HOH R 5 .   ? 22.51141  -6.56323  55.90123  1.000 42.17076 ?  570 HOH A O   1 
HETATM 3782 O  O   . HOH R 5 .   ? 16.87720  8.64443   19.49223  1.000 24.18353 ?  571 HOH A O   1 
HETATM 3783 O  O   . HOH R 5 .   ? 13.73474  -6.84481  51.16676  1.000 21.56536 ?  572 HOH A O   1 
HETATM 3784 O  O   . HOH R 5 .   ? 2.77083   2.48148   30.29081  1.000 38.19689 ?  573 HOH A O   1 
HETATM 3785 O  O   . HOH R 5 .   ? 31.54383  1.34091   43.55601  1.000 25.05815 ?  574 HOH A O   1 
HETATM 3786 O  O   . HOH R 5 .   ? 33.87330  10.12865  43.78142  1.000 30.85344 ?  575 HOH A O   1 
HETATM 3787 O  O   . HOH R 5 .   ? 21.91331  9.53190   51.96057  1.000 23.95137 ?  576 HOH A O   1 
HETATM 3788 O  O   . HOH R 5 .   ? 25.71251  -3.80255  22.16763  1.000 17.31094 ?  577 HOH A O   1 
HETATM 3789 O  O   . HOH R 5 .   ? 34.08972  14.43353  34.59431  1.000 34.64958 ?  578 HOH A O   1 
HETATM 3790 O  O   . HOH R 5 .   ? 14.36729  11.78343  21.67744  1.000 21.80763 ?  579 HOH A O   1 
HETATM 3791 O  O   . HOH R 5 .   ? 0.78653   13.76966  32.68904  1.000 35.89880 ?  580 HOH A O   1 
HETATM 3792 O  O   . HOH R 5 .   ? 17.32557  2.74229   30.89438  1.000 17.68661 ?  581 HOH A O   1 
HETATM 3793 O  O   . HOH R 5 .   ? 31.97243  -9.66810  48.44253  1.000 23.37395 ?  582 HOH A O   1 
HETATM 3794 O  O   . HOH R 5 .   ? 32.84407  8.15418   50.90138  1.000 28.13992 ?  583 HOH A O   1 
HETATM 3795 O  O   . HOH R 5 .   ? 18.70476  12.71968  49.81049  1.000 30.12159 ?  584 HOH A O   1 
HETATM 3796 O  O   . HOH R 5 .   ? 29.46740  9.82588   44.37260  1.000 22.15976 ?  585 HOH A O   1 
HETATM 3797 O  O   . HOH R 5 .   ? 7.42102   -12.96403 34.51270  1.000 30.83359 ?  586 HOH A O   1 
HETATM 3798 O  O   . HOH R 5 .   ? 22.11217  -9.87882  60.73414  1.000 41.60292 ?  587 HOH A O   1 
HETATM 3799 O  O   . HOH R 5 .   ? 13.54179  18.35055  39.01254  1.000 27.16614 ?  588 HOH A O   1 
HETATM 3800 O  O   . HOH R 5 .   ? 39.67833  5.80606   29.74056  1.000 29.78041 ?  589 HOH A O   1 
HETATM 3801 O  O   . HOH R 5 .   ? 39.32416  0.54521   41.89273  1.000 27.91945 ?  590 HOH A O   1 
HETATM 3802 O  O   . HOH R 5 .   ? 12.11645  14.50183  47.45948  1.000 39.20050 ?  591 HOH A O   1 
HETATM 3803 O  O   . HOH R 5 .   ? 29.19030  -7.20300  22.77714  1.000 27.87260 ?  592 HOH A O   1 
HETATM 3804 O  O   . HOH R 5 .   ? 7.70795   16.04322  43.20130  1.000 23.43050 ?  593 HOH A O   1 
HETATM 3805 O  O   . HOH R 5 .   ? 17.69790  19.31253  21.89860  1.000 32.01531 ?  594 HOH A O   1 
HETATM 3806 O  O   . HOH R 5 .   ? 33.83513  8.41478   25.18404  1.000 31.14531 ?  595 HOH A O   1 
HETATM 3807 O  O   . HOH R 5 .   ? 20.64408  -25.64966 32.96815  1.000 39.56786 ?  596 HOH A O   1 
HETATM 3808 O  O   . HOH R 5 .   ? 13.38620  -21.51810 42.22576  1.000 31.65619 ?  597 HOH A O   1 
HETATM 3809 O  O   . HOH R 5 .   ? 24.51990  28.67939  23.69003  1.000 39.36748 ?  598 HOH A O   1 
HETATM 3810 O  O   . HOH R 5 .   ? 27.788    -17.991   46.667    1.000 30.25691 ?  599 HOH A O   1 
HETATM 3811 O  O   . HOH R 5 .   ? 11.48306  17.85478  39.52788  1.000 33.62380 ?  600 HOH A O   1 
HETATM 3812 O  O   . HOH R 5 .   ? 24.10104  -21.76144 28.19773  1.000 34.17161 ?  601 HOH A O   1 
HETATM 3813 O  O   . HOH R 5 .   ? 26.87410  13.46924  20.18460  1.000 32.93849 ?  602 HOH A O   1 
HETATM 3814 O  O   . HOH R 5 .   ? 23.41118  7.67743   52.44096  1.000 37.79380 ?  603 HOH A O   1 
HETATM 3815 O  O   . HOH R 5 .   ? 10.97151  -23.05072 38.94785  1.000 38.14526 ?  604 HOH A O   1 
HETATM 3816 O  O   . HOH R 5 .   ? 14.09406  -3.35234  31.13476  1.000 23.81408 ?  605 HOH A O   1 
HETATM 3817 O  O   . HOH R 5 .   ? 28.829    -16.693   51.327    1.000 36.66671 ?  606 HOH A O   1 
HETATM 3818 O  O   . HOH R 5 .   ? 27.74564  22.44383  19.17441  1.000 35.34291 ?  607 HOH A O   1 
HETATM 3819 O  O   . HOH R 5 .   ? 31.34910  7.39768   24.75066  1.000 24.58779 ?  608 HOH A O   1 
HETATM 3820 O  O   . HOH R 5 .   ? 16.07658  15.36693  42.94795  1.000 27.34651 ?  609 HOH A O   1 
HETATM 3821 O  O   . HOH R 5 .   ? 32.44749  -10.89973 33.95643  1.000 22.67844 ?  610 HOH A O   1 
HETATM 3822 O  O   . HOH R 5 .   ? 27.74268  -8.77615  63.03604  1.000 53.71452 ?  611 HOH A O   1 
HETATM 3823 O  O   . HOH R 5 .   ? 40.33980  -0.18309  34.87987  1.000 37.95893 ?  612 HOH A O   1 
HETATM 3824 O  O   . HOH R 5 .   ? 11.79097  -14.02684 36.84098  1.000 25.66262 ?  613 HOH A O   1 
HETATM 3825 O  O   . HOH R 5 .   ? 29.17328  -15.67523 46.96608  1.000 33.01130 ?  614 HOH A O   1 
HETATM 3826 O  O   . HOH R 5 .   ? 22.26338  27.90459  22.82319  1.000 34.35854 ?  615 HOH A O   1 
HETATM 3827 O  O   . HOH R 5 .   ? 14.54386  20.31155  37.74161  1.000 35.18031 ?  616 HOH A O   1 
HETATM 3828 O  O   . HOH R 5 .   ? 20.76985  16.50503  47.84399  1.000 29.82651 ?  617 HOH A O   1 
HETATM 3829 O  O   . HOH R 5 .   ? 9.45596   17.39792  44.28018  1.000 37.54715 ?  618 HOH A O   1 
HETATM 3830 O  O   . HOH R 5 .   ? 24.45991  19.24730  16.68142  1.000 32.34336 ?  619 HOH A O   1 
HETATM 3831 O  O   . HOH R 5 .   ? 17.05354  -19.53688 46.47149  1.000 18.92269 ?  620 HOH A O   1 
HETATM 3832 O  O   . HOH R 5 .   ? 31.38287  16.49069  26.43878  1.000 27.33287 ?  621 HOH A O   1 
HETATM 3833 O  O   . HOH R 5 .   ? 30.79246  -8.91867  23.80625  1.000 32.05363 ?  622 HOH A O   1 
HETATM 3834 O  O   . HOH R 5 .   ? 16.48718  13.38996  49.38636  1.000 32.84565 ?  623 HOH A O   1 
HETATM 3835 O  O   . HOH R 5 .   ? 33.58567  5.48054   50.60964  1.000 36.63766 ?  624 HOH A O   1 
HETATM 3836 O  O   . HOH R 5 .   ? -1.01192  8.98467   44.10611  1.000 35.67635 ?  625 HOH A O   1 
HETATM 3837 O  O   . HOH R 5 .   ? 5.42288   -1.34674  29.66557  1.000 33.58799 ?  626 HOH A O   1 
HETATM 3838 O  O   . HOH R 5 .   ? 21.81988  3.78265   15.16768  1.000 25.75111 ?  627 HOH A O   1 
HETATM 3839 O  O   . HOH R 5 .   ? -3.07275  7.46136   31.77395  1.000 32.57189 ?  628 HOH A O   1 
HETATM 3840 O  O   . HOH R 5 .   ? 23.36866  -20.66376 34.16772  1.000 30.04670 ?  629 HOH A O   1 
HETATM 3841 O  O   . HOH R 5 .   ? 12.67676  -17.49523 35.38873  1.000 25.52162 ?  630 HOH A O   1 
HETATM 3842 O  O   . HOH R 5 .   ? 8.31925   7.83725   26.47268  1.000 32.82369 ?  631 HOH A O   1 
HETATM 3843 O  O   . HOH R 5 .   ? 19.34287  11.84251  52.24492  1.000 43.49834 ?  632 HOH A O   1 
HETATM 3844 O  O   . HOH R 5 .   ? 31.057    12.412    48.155    1.000 33.82960 ?  633 HOH A O   1 
HETATM 3845 O  O   . HOH R 5 .   ? 4.73983   -4.31942  33.89929  1.000 25.66145 ?  634 HOH A O   1 
HETATM 3846 O  O   . HOH R 5 .   ? 34.61929  -10.17024 33.03953  1.000 30.31338 ?  635 HOH A O   1 
HETATM 3847 O  O   . HOH R 5 .   ? 17.95827  17.62774  46.17684  1.000 32.96965 ?  636 HOH A O   1 
HETATM 3848 O  O   . HOH R 5 .   ? 10.04087  9.35395   26.65101  1.000 35.40735 ?  637 HOH A O   1 
HETATM 3849 O  O   . HOH R 5 .   ? 31.38724  10.23867  43.23692  1.000 38.57794 ?  638 HOH A O   1 
HETATM 3850 O  O   . HOH R 5 .   ? 29.26214  17.01539  38.39905  1.000 25.20380 ?  639 HOH A O   1 
HETATM 3851 O  O   . HOH R 5 .   ? 22.07904  -20.38561 36.12097  1.000 29.26078 ?  640 HOH A O   1 
HETATM 3852 O  O   . HOH R 5 .   ? 30.74969  -1.85803  51.81757  1.000 34.39231 ?  641 HOH A O   1 
HETATM 3853 O  O   . HOH R 5 .   ? 19.21150  20.87867  15.52859  1.000 39.71524 ?  642 HOH A O   1 
HETATM 3854 O  O   . HOH R 5 .   ? 24.86412  -18.13246 26.89429  1.000 38.30978 ?  643 HOH A O   1 
HETATM 3855 O  O   . HOH R 5 .   ? -2.69382  10.63167  39.98387  1.000 36.09955 ?  644 HOH A O   1 
HETATM 3856 O  O   . HOH R 5 .   ? -0.91955  9.38180   41.58979  1.000 18.05909 ?  645 HOH A O   1 
HETATM 3857 O  O   . HOH R 5 .   ? 4.21335   -5.32088  36.30526  1.000 32.72538 ?  646 HOH A O   1 
HETATM 3858 O  O   . HOH R 5 .   ? 13.48015  18.75558  29.92462  1.000 32.99004 ?  647 HOH A O   1 
HETATM 3859 O  O   . HOH R 5 .   ? -0.68033  8.20620   30.63491  1.000 43.33560 ?  648 HOH A O   1 
HETATM 3860 O  O   . HOH R 5 .   ? 5.84987   6.22353   25.82216  1.000 32.50380 ?  649 HOH A O   1 
HETATM 3861 O  O   . HOH R 5 .   ? 10.83423  -2.26771  51.33535  1.000 26.51390 ?  650 HOH A O   1 
HETATM 3862 O  O   . HOH R 5 .   ? 26.38601  4.71923   16.37364  1.000 31.24973 ?  651 HOH A O   1 
HETATM 3863 O  O   . HOH R 5 .   ? 30.50563  -2.08000  19.41914  1.000 30.68524 ?  652 HOH A O   1 
HETATM 3864 O  O   . HOH R 5 .   ? 1.42550   3.86979   31.84657  1.000 33.88830 ?  653 HOH A O   1 
HETATM 3865 O  O   . HOH R 5 .   ? 22.19041  -13.52578 19.79783  1.000 33.62245 ?  654 HOH A O   1 
HETATM 3866 O  O   . HOH R 5 .   ? 12.58128  -23.45134 30.26781  1.000 24.52089 ?  655 HOH A O   1 
HETATM 3867 O  O   . HOH R 5 .   ? 31.43541  -4.62779  52.02188  1.000 44.28176 ?  656 HOH A O   1 
HETATM 3868 O  O   . HOH R 5 .   ? 9.76117   8.09231   54.71732  1.000 55.07498 ?  657 HOH A O   1 
HETATM 3869 O  O   . HOH R 5 .   ? 26.36484  -23.00899 29.49451  1.000 41.55848 ?  658 HOH A O   1 
HETATM 3870 O  O   . HOH R 5 .   ? 1.44694   6.29079   31.00204  1.000 37.16182 ?  659 HOH A O   1 
HETATM 3871 O  O   . HOH R 5 .   ? 32.31866  6.39892   22.62226  1.000 31.52569 ?  660 HOH A O   1 
HETATM 3872 O  O   . HOH R 5 .   ? 8.19281   -12.75650 36.65998  1.000 28.98108 ?  661 HOH A O   1 
HETATM 3873 O  O   . HOH R 5 .   ? 31.21438  -14.02245 26.63480  1.000 35.85904 ?  662 HOH A O   1 
HETATM 3874 O  O   . HOH R 5 .   ? 14.45451  13.22150  48.01681  1.000 37.74778 ?  663 HOH A O   1 
HETATM 3875 O  O   . HOH R 5 .   ? -1.84381  3.57610   43.92312  1.000 29.09303 ?  664 HOH A O   1 
HETATM 3876 O  O   . HOH R 5 .   ? 27.07565  -13.77821 20.88360  1.000 41.80580 ?  665 HOH A O   1 
HETATM 3877 O  O   . HOH R 5 .   ? 32.56154  19.59705  23.67091  1.000 38.32240 ?  666 HOH A O   1 
HETATM 3878 O  O   . HOH R 5 .   ? 32.73265  -13.13778 28.26547  1.000 35.19340 ?  667 HOH A O   1 
HETATM 3879 O  O   . HOH R 5 .   ? 24.42334  12.08730  19.23216  1.000 32.78528 ?  668 HOH A O   1 
HETATM 3880 O  O   . HOH R 5 .   ? 39.54764  -0.74986  43.72314  1.000 45.62193 ?  669 HOH A O   1 
HETATM 3881 O  O   . HOH R 5 .   ? 34.27160  16.61085  32.34026  1.000 36.42700 ?  670 HOH A O   1 
HETATM 3882 O  O   . HOH R 5 .   ? 27.31765  30.23133  21.87958  1.000 35.45279 ?  671 HOH A O   1 
HETATM 3883 O  O   . HOH R 5 .   ? 28.53030  30.13976  24.24841  1.000 51.73931 ?  672 HOH A O   1 
HETATM 3884 O  O   . HOH R 5 .   ? 13.10813  -27.30013 27.37850  1.000 46.75086 ?  673 HOH A O   1 
HETATM 3885 O  O   . HOH R 5 .   ? 13.93630  -27.41125 25.35474  1.000 52.95484 ?  674 HOH A O   1 
HETATM 3886 O  O   . HOH S 5 .   ? -11.82387 4.19991   -4.70855  1.000 36.55448 ?  401 HOH B O   1 
HETATM 3887 O  O   . HOH S 5 .   ? -5.87190  -11.61415 7.79278   1.000 32.83494 ?  402 HOH B O   1 
HETATM 3888 O  O   . HOH S 5 .   ? 9.32608   24.61619  19.12847  1.000 35.15064 ?  403 HOH B O   1 
HETATM 3889 O  O   . HOH S 5 .   ? 11.51023  24.40862  11.44091  1.000 39.16988 ?  404 HOH B O   1 
HETATM 3890 O  O   . HOH S 5 .   ? -11.11230 20.14858  5.27376   1.000 29.13159 ?  405 HOH B O   1 
HETATM 3891 O  O   . HOH S 5 .   ? -12.81689 -2.56073  6.27302   1.000 34.23741 ?  406 HOH B O   1 
HETATM 3892 O  O   . HOH S 5 .   ? -1.23905  24.91167  5.10894   1.000 20.58259 ?  407 HOH B O   1 
HETATM 3893 O  O   . HOH S 5 .   ? 10.46349  -5.91528  19.12587  1.000 33.91708 ?  408 HOH B O   1 
HETATM 3894 O  O   . HOH S 5 .   ? 11.257    -19.608   10.000    1.000 39.55020 ?  409 HOH B O   1 
HETATM 3895 O  O   . HOH S 5 .   ? 1.50863   -2.69688  8.19508   1.000 10.42117 ?  410 HOH B O   1 
HETATM 3896 O  O   . HOH S 5 .   ? -3.90024  14.63100  8.58885   1.000 17.30819 ?  411 HOH B O   1 
HETATM 3897 O  O   . HOH S 5 .   ? -11.90529 1.93120   -2.66553  1.000 45.12135 ?  412 HOH B O   1 
HETATM 3898 O  O   . HOH S 5 .   ? 19.94873  -8.93251  7.51536   1.000 31.67520 ?  413 HOH B O   1 
HETATM 3899 O  O   . HOH S 5 .   ? -11.17074 11.34173  7.42655   1.000 30.36236 ?  414 HOH B O   1 
HETATM 3900 O  O   . HOH S 5 .   ? 1.33821   19.45579  12.37413  1.000 20.16845 ?  415 HOH B O   1 
HETATM 3901 O  O   . HOH S 5 .   ? -13.53988 14.14868  -4.05918  1.000 32.82093 ?  416 HOH B O   1 
HETATM 3902 O  O   . HOH S 5 .   ? 16.77906  16.95085  5.80845   1.000 23.54646 ?  417 HOH B O   1 
HETATM 3903 O  O   . HOH S 5 .   ? 3.98754   24.09237  8.61084   1.000 24.33313 ?  418 HOH B O   1 
HETATM 3904 O  O   . HOH S 5 .   ? 9.39758   17.84783  6.83148   1.000 16.35129 ?  419 HOH B O   1 
HETATM 3905 O  O   . HOH S 5 .   ? 14.41943  -4.45386  -10.88587 1.000 41.29672 ?  420 HOH B O   1 
HETATM 3906 O  O   . HOH S 5 .   ? -12.60797 7.78097   11.57344  1.000 32.93069 ?  421 HOH B O   1 
HETATM 3907 O  O   . HOH S 5 .   ? 8.11090   8.05063   12.60210  1.000 21.44658 ?  422 HOH B O   1 
HETATM 3908 O  O   . HOH S 5 .   ? -13.18661 0.94832   20.30916  1.000 21.33086 ?  423 HOH B O   1 
HETATM 3909 O  O   . HOH S 5 .   ? 6.65571   -4.91417  -10.06395 1.000 33.57464 ?  424 HOH B O   1 
HETATM 3910 O  O   . HOH S 5 .   ? 23.15361  10.27137  8.91058   1.000 38.23198 ?  425 HOH B O   1 
HETATM 3911 O  O   . HOH S 5 .   ? 6.65186   -12.47811 6.78419   1.000 13.12089 ?  426 HOH B O   1 
HETATM 3912 O  O   . HOH S 5 .   ? -6.13875  21.59694  2.07580   1.000 22.27486 ?  427 HOH B O   1 
HETATM 3913 O  O   . HOH S 5 .   ? 13.96406  -4.77800  -2.79940  1.000 19.94252 ?  428 HOH B O   1 
HETATM 3914 O  O   . HOH S 5 .   ? -3.46865  4.01629   12.50823  1.000 15.02310 ?  429 HOH B O   1 
HETATM 3915 O  O   . HOH S 5 .   ? -6.02197  15.79223  7.21413   1.000 19.03844 ?  430 HOH B O   1 
HETATM 3916 O  O   . HOH S 5 .   ? 11.69621  5.47104   -10.04812 1.000 29.98680 ?  431 HOH B O   1 
HETATM 3917 O  O   . HOH S 5 .   ? 11.91807  20.16540  8.93075   1.000 17.96548 ?  432 HOH B O   1 
HETATM 3918 O  O   . HOH S 5 .   ? -12.76113 4.30483   15.64571  1.000 26.05794 ?  433 HOH B O   1 
HETATM 3919 O  O   . HOH S 5 .   ? -5.61686  21.78353  -9.34079  1.000 29.83144 ?  434 HOH B O   1 
HETATM 3920 O  O   . HOH S 5 .   ? -3.78083  -10.87228 -5.52091  1.000 29.85558 ?  435 HOH B O   1 
HETATM 3921 O  O   . HOH S 5 .   ? -9.53364  16.85600  8.57262   1.000 28.17005 ?  436 HOH B O   1 
HETATM 3922 O  O   . HOH S 5 .   ? 7.55192   -4.50248  15.19998  1.000 11.95012 ?  437 HOH B O   1 
HETATM 3923 O  O   . HOH S 5 .   ? 18.06295  1.71609   12.10388  1.000 11.62695 ?  438 HOH B O   1 
HETATM 3924 O  O   . HOH S 5 .   ? 18.35806  15.94463  15.02562  1.000 27.65271 ?  439 HOH B O   1 
HETATM 3925 O  O   . HOH S 5 .   ? 18.03628  8.88390   4.71213   1.000 22.83011 ?  440 HOH B O   1 
HETATM 3926 O  O   . HOH S 5 .   ? 17.59847  1.77551   -8.31851  1.000 28.23760 ?  441 HOH B O   1 
HETATM 3927 O  O   . HOH S 5 .   ? 15.58530  -6.70536  -2.53870  1.000 34.77496 ?  442 HOH B O   1 
HETATM 3928 O  O   . HOH S 5 .   ? 8.88925   20.46272  7.75639   1.000 13.78355 ?  443 HOH B O   1 
HETATM 3929 O  O   . HOH S 5 .   ? -12.10577 -9.47922  14.94539  1.000 30.12380 ?  444 HOH B O   1 
HETATM 3930 O  O   . HOH S 5 .   ? 15.15732  5.71770   -3.54678  1.000 16.91167 ?  445 HOH B O   1 
HETATM 3931 O  O   . HOH S 5 .   ? 11.04615  16.70098  2.72749   1.000 19.26535 ?  446 HOH B O   1 
HETATM 3932 O  O   . HOH S 5 .   ? -5.81339  -0.42562  22.50522  1.000 29.01830 ?  447 HOH B O   1 
HETATM 3933 O  O   . HOH S 5 .   ? -10.09445 23.83378  -2.75633  1.000 19.29811 ?  448 HOH B O   1 
HETATM 3934 O  O   . HOH S 5 .   ? -9.33953  9.38266   8.76088   1.000 17.85959 ?  449 HOH B O   1 
HETATM 3935 O  O   . HOH S 5 .   ? 14.60887  8.32785   18.09999  1.000 20.97544 ?  450 HOH B O   1 
HETATM 3936 O  O   . HOH S 5 .   ? 21.28014  -2.81992  -5.90922  1.000 35.06568 ?  451 HOH B O   1 
HETATM 3937 O  O   . HOH S 5 .   ? 6.25853   15.86026  20.16925  1.000 19.24262 ?  452 HOH B O   1 
HETATM 3938 O  O   . HOH S 5 .   ? 6.24390   -11.59990 0.45748   1.000 12.64669 ?  453 HOH B O   1 
HETATM 3939 O  O   . HOH S 5 .   ? 2.72661   3.45473   10.05187  1.000 20.49289 ?  454 HOH B O   1 
HETATM 3940 O  O   . HOH S 5 .   ? 7.79562   26.94884  6.59162   1.000 28.77892 ?  455 HOH B O   1 
HETATM 3941 O  O   . HOH S 5 .   ? 15.13695  -12.71442 13.37674  1.000 13.79576 ?  456 HOH B O   1 
HETATM 3942 O  O   . HOH S 5 .   ? 18.52765  19.56997  11.48069  1.000 25.02989 ?  457 HOH B O   1 
HETATM 3943 O  O   . HOH S 5 .   ? 4.24068   -11.65964 -3.67028  1.000 21.88153 ?  458 HOH B O   1 
HETATM 3944 O  O   . HOH S 5 .   ? 10.18365  13.51769  15.14079  1.000 10.00385 ?  459 HOH B O   1 
HETATM 3945 O  O   . HOH S 5 .   ? 8.12083   26.39099  20.48450  1.000 44.56045 ?  460 HOH B O   1 
HETATM 3946 O  O   . HOH S 5 .   ? 15.81784  -6.46898  17.38313  1.000 19.64950 ?  461 HOH B O   1 
HETATM 3947 O  O   . HOH S 5 .   ? 9.87818   24.47159  1.82986   1.000 32.39477 ?  462 HOH B O   1 
HETATM 3948 O  O   . HOH S 5 .   ? 17.67543  4.58689   -2.88253  1.000 19.27308 ?  463 HOH B O   1 
HETATM 3949 O  O   . HOH S 5 .   ? -0.17503  22.14830  9.43544   1.000 26.06164 ?  464 HOH B O   1 
HETATM 3950 O  O   . HOH S 5 .   ? 12.67037  14.89456  -0.49573  1.000 15.79977 ?  465 HOH B O   1 
HETATM 3951 O  O   . HOH S 5 .   ? 8.17432   4.38527   -10.70108 1.000 30.16865 ?  466 HOH B O   1 
HETATM 3952 O  O   . HOH S 5 .   ? 22.20800  -3.01325  15.28911  1.000 24.17209 ?  467 HOH B O   1 
HETATM 3953 O  O   . HOH S 5 .   ? 12.66279  18.34062  -3.34941  1.000 27.77883 ?  468 HOH B O   1 
HETATM 3954 O  O   . HOH S 5 .   ? -4.19924  9.92153   13.07126  1.000 13.99534 ?  469 HOH B O   1 
HETATM 3955 O  O   . HOH S 5 .   ? -9.42714  -3.97959  18.06120  1.000 17.58087 ?  470 HOH B O   1 
HETATM 3956 O  O   . HOH S 5 .   ? -0.86438  -11.19662 16.87887  1.000 30.23577 ?  471 HOH B O   1 
HETATM 3957 O  O   . HOH S 5 .   ? 10.32329  -10.35552 18.10506  1.000 30.24451 ?  472 HOH B O   1 
HETATM 3958 O  O   . HOH S 5 .   ? 4.58834   6.02491   14.94369  1.000 30.67310 ?  473 HOH B O   1 
HETATM 3959 O  O   . HOH S 5 .   ? 6.81334   -8.51681  17.37774  1.000 16.07645 ?  474 HOH B O   1 
HETATM 3960 O  O   . HOH S 5 .   ? 2.35624   -6.80872  7.17022   1.000 11.05290 ?  475 HOH B O   1 
HETATM 3961 O  O   . HOH S 5 .   ? 10.67522  16.54960  0.04629   1.000 16.04693 ?  476 HOH B O   1 
HETATM 3962 O  O   . HOH S 5 .   ? 18.02698  -7.30411  12.64382  1.000 16.15480 ?  477 HOH B O   1 
HETATM 3963 O  O   . HOH S 5 .   ? 22.40515  -17.24754 12.51173  1.000 37.00664 ?  478 HOH B O   1 
HETATM 3964 O  O   . HOH S 5 .   ? 19.73482  -0.23845  2.56165   1.000 23.10046 ?  479 HOH B O   1 
HETATM 3965 O  O   . HOH S 5 .   ? 20.14804  14.65900  14.19094  1.000 21.15679 ?  480 HOH B O   1 
HETATM 3966 O  O   . HOH S 5 .   ? 1.32151   13.99020  5.45392   1.000 14.07098 ?  481 HOH B O   1 
HETATM 3967 O  O   . HOH S 5 .   ? -6.96470  -7.66134  -1.49624  1.000 35.27533 ?  482 HOH B O   1 
HETATM 3968 O  O   . HOH S 5 .   ? 14.58378  20.78894  7.39234   1.000 25.10591 ?  483 HOH B O   1 
HETATM 3969 O  O   . HOH S 5 .   ? 18.78045  -9.64853  3.35343   1.000 26.10672 ?  484 HOH B O   1 
HETATM 3970 O  O   . HOH S 5 .   ? 18.82108  19.37990  7.85163   1.000 30.80651 ?  485 HOH B O   1 
HETATM 3971 O  O   . HOH S 5 .   ? 24.10536  3.96014   5.88098   1.000 27.92127 ?  486 HOH B O   1 
HETATM 3972 O  O   . HOH S 5 .   ? 5.01379   2.85525   12.14102  1.000 30.38427 ?  487 HOH B O   1 
HETATM 3973 O  O   . HOH S 5 .   ? 3.82313   -12.40467 13.37767  1.000 27.48455 ?  488 HOH B O   1 
HETATM 3974 O  O   . HOH S 5 .   ? 13.65575  -1.55588  11.76493  1.000 12.93353 ?  489 HOH B O   1 
HETATM 3975 O  O   . HOH S 5 .   ? 8.04735   16.90020  -8.34682  1.000 30.30697 ?  490 HOH B O   1 
HETATM 3976 O  O   . HOH S 5 .   ? 7.26740   -11.42902 14.95464  1.000 19.17618 ?  491 HOH B O   1 
HETATM 3977 O  O   . HOH S 5 .   ? -5.05028  13.76630  12.24749  1.000 25.06304 ?  492 HOH B O   1 
HETATM 3978 O  O   . HOH S 5 .   ? 10.36603  -0.74501  8.07437   1.000 8.64532  ?  493 HOH B O   1 
HETATM 3979 O  O   . HOH S 5 .   ? 5.10508   -8.28248  5.98091   1.000 10.72751 ?  494 HOH B O   1 
HETATM 3980 O  O   . HOH S 5 .   ? 20.77203  11.54116  10.06269  1.000 29.83299 ?  495 HOH B O   1 
HETATM 3981 O  O   . HOH S 5 .   ? 20.15598  -17.59813 4.62188   1.000 31.94248 ?  496 HOH B O   1 
HETATM 3982 O  O   . HOH S 5 .   ? 11.06517  20.57126  22.94067  1.000 38.78864 ?  497 HOH B O   1 
HETATM 3983 O  O   . HOH S 5 .   ? 7.559     -13.716   4.001     1.000 27.93378 ?  498 HOH B O   1 
HETATM 3984 O  O   . HOH S 5 .   ? 6.89825   1.33384   22.95427  1.000 28.26228 ?  499 HOH B O   1 
HETATM 3985 O  O   . HOH S 5 .   ? 12.74308  15.28001  24.28265  1.000 24.37818 ?  500 HOH B O   1 
HETATM 3986 O  O   . HOH S 5 .   ? -4.49706  -8.63979  -1.87662  1.000 27.26617 ?  501 HOH B O   1 
HETATM 3987 O  O   . HOH S 5 .   ? -6.41425  4.69409   20.10595  1.000 28.89516 ?  502 HOH B O   1 
HETATM 3988 O  O   . HOH S 5 .   ? 1.42268   -0.87483  22.18943  1.000 20.91755 ?  503 HOH B O   1 
HETATM 3989 O  O   . HOH S 5 .   ? 11.99565  10.89590  20.68777  1.000 27.52380 ?  504 HOH B O   1 
HETATM 3990 O  O   . HOH S 5 .   ? 9.12140   8.83373   -4.86677  1.000 20.29497 ?  505 HOH B O   1 
HETATM 3991 O  O   . HOH S 5 .   ? -1.42005  -12.01443 2.27711   1.000 22.18143 ?  506 HOH B O   1 
HETATM 3992 O  O   . HOH S 5 .   ? 15.49987  17.90291  17.10407  1.000 17.95336 ?  507 HOH B O   1 
HETATM 3993 O  O   . HOH S 5 .   ? -6.45719  -4.69715  -5.43782  1.000 24.74231 ?  508 HOH B O   1 
HETATM 3994 O  O   . HOH S 5 .   ? -9.48683  -5.46411  2.45461   1.000 21.39100 ?  509 HOH B O   1 
HETATM 3995 O  O   . HOH S 5 .   ? -10.95974 11.61789  1.36932   1.000 24.35949 ?  510 HOH B O   1 
HETATM 3996 O  O   . HOH S 5 .   ? 21.13126  10.86036  -1.08392  1.000 29.48922 ?  511 HOH B O   1 
HETATM 3997 O  O   . HOH S 5 .   ? -0.51563  7.00718   18.75036  1.000 21.06023 ?  512 HOH B O   1 
HETATM 3998 O  O   . HOH S 5 .   ? 8.30599   2.68687   13.38940  1.000 24.03730 ?  513 HOH B O   1 
HETATM 3999 O  O   . HOH S 5 .   ? 17.38989  -12.93327 20.37976  1.000 21.31004 ?  514 HOH B O   1 
HETATM 4000 O  O   . HOH S 5 .   ? 11.69111  -2.98463  -9.07988  1.000 26.58733 ?  515 HOH B O   1 
HETATM 4001 O  O   . HOH S 5 .   ? 6.30274   15.48565  8.80894   1.000 17.17792 ?  516 HOH B O   1 
HETATM 4002 O  O   . HOH S 5 .   ? 23.33906  -1.04633  10.83225  1.000 26.16191 ?  517 HOH B O   1 
HETATM 4003 O  O   . HOH S 5 .   ? 2.54591   -3.51816  20.55411  1.000 30.86335 ?  518 HOH B O   1 
HETATM 4004 O  O   . HOH S 5 .   ? 22.36115  -7.59807  16.58535  1.000 19.61878 ?  519 HOH B O   1 
HETATM 4005 O  O   . HOH S 5 .   ? 14.80504  14.64129  5.91712   1.000 19.16231 ?  520 HOH B O   1 
HETATM 4006 O  O   . HOH S 5 .   ? 9.89114   -3.06062  6.57488   1.000 11.30216 ?  521 HOH B O   1 
HETATM 4007 O  O   . HOH S 5 .   ? 9.56435   20.30432  -7.32558  1.000 41.94799 ?  522 HOH B O   1 
HETATM 4008 O  O   . HOH S 5 .   ? 13.83056  6.81598   21.62425  1.000 29.18917 ?  523 HOH B O   1 
HETATM 4009 O  O   . HOH S 5 .   ? 22.62486  7.63468   7.94885   1.000 26.22641 ?  524 HOH B O   1 
HETATM 4010 O  O   . HOH S 5 .   ? 0.61684   24.32304  8.28578   1.000 26.87537 ?  525 HOH B O   1 
HETATM 4011 O  O   . HOH S 5 .   ? 4.46091   -4.06788  17.70981  1.000 22.65669 ?  526 HOH B O   1 
HETATM 4012 O  O   . HOH S 5 .   ? 20.99715  -4.15917  9.91409   1.000 25.52668 ?  527 HOH B O   1 
HETATM 4013 O  O   . HOH S 5 .   ? -6.07663  0.18914   20.47723  1.000 30.17347 ?  528 HOH B O   1 
HETATM 4014 O  O   . HOH S 5 .   ? -6.53858  -10.41321 14.76257  1.000 29.24004 ?  529 HOH B O   1 
HETATM 4015 O  O   . HOH S 5 .   ? 22.71140  9.21985   -1.63223  1.000 43.24188 ?  530 HOH B O   1 
HETATM 4016 O  O   . HOH S 5 .   ? 19.32123  8.77363   9.45371   1.000 17.69997 ?  531 HOH B O   1 
HETATM 4017 O  O   . HOH S 5 .   ? -0.92600  26.88748  2.78041   1.000 21.99606 ?  532 HOH B O   1 
HETATM 4018 O  O   . HOH S 5 .   ? -6.62133  -0.92463  25.85004  1.000 27.37577 ?  533 HOH B O   1 
HETATM 4019 O  O   . HOH S 5 .   ? 16.24910  -3.68944  18.04388  1.000 23.60578 ?  534 HOH B O   1 
HETATM 4020 O  O   . HOH S 5 .   ? -9.16008  -9.11582  5.01380   1.000 38.06960 ?  535 HOH B O   1 
HETATM 4021 O  O   . HOH S 5 .   ? -7.89805  -11.21694 11.36582  1.000 24.34476 ?  536 HOH B O   1 
HETATM 4022 O  O   . HOH S 5 .   ? 15.13866  19.97305  -2.12506  1.000 30.27462 ?  537 HOH B O   1 
HETATM 4023 O  O   . HOH S 5 .   ? 1.61459   14.14757  -11.41148 1.000 36.20756 ?  538 HOH B O   1 
HETATM 4024 O  O   . HOH S 5 .   ? 4.487     27.015    8.240     1.000 33.60964 ?  539 HOH B O   1 
HETATM 4025 O  O   . HOH S 5 .   ? -12.93959 22.75925  0.16552   1.000 22.85890 ?  540 HOH B O   1 
HETATM 4026 O  O   . HOH S 5 .   ? -4.20589  26.03243  7.11662   1.000 38.56709 ?  541 HOH B O   1 
HETATM 4027 O  O   . HOH S 5 .   ? -13.97683 0.88743   -2.78767  1.000 31.94343 ?  542 HOH B O   1 
HETATM 4028 O  O   . HOH S 5 .   ? 10.08416  25.73836  13.34129  1.000 32.52742 ?  543 HOH B O   1 
HETATM 4029 O  O   . HOH S 5 .   ? 11.96072  24.38108  3.17233   1.000 31.90380 ?  544 HOH B O   1 
HETATM 4030 O  O   . HOH S 5 .   ? 12.92810  -6.88924  18.76256  1.000 27.31114 ?  545 HOH B O   1 
HETATM 4031 O  O   . HOH S 5 .   ? -7.55743  9.45399   16.64621  1.000 26.61167 ?  546 HOH B O   1 
HETATM 4032 O  O   . HOH S 5 .   ? 22.14720  11.66480  12.50006  1.000 31.08380 ?  547 HOH B O   1 
HETATM 4033 O  O   . HOH S 5 .   ? 6.41669   2.22247   -10.53726 1.000 31.13107 ?  548 HOH B O   1 
HETATM 4034 O  O   . HOH S 5 .   ? -0.62396  20.70230  16.44052  1.000 22.46830 ?  549 HOH B O   1 
HETATM 4035 O  O   . HOH S 5 .   ? 21.47822  -0.61460  -6.19684  1.000 39.83564 ?  550 HOH B O   1 
HETATM 4036 O  O   . HOH S 5 .   ? 2.79859   29.11736  9.27993   1.000 33.66667 ?  551 HOH B O   1 
HETATM 4037 O  O   . HOH S 5 .   ? 3.578     -9.621    -6.175    1.000 41.38672 ?  552 HOH B O   1 
HETATM 4038 O  O   . HOH S 5 .   ? 8.56450   -13.22697 0.30431   1.000 27.14758 ?  553 HOH B O   1 
HETATM 4039 O  O   . HOH S 5 .   ? 1.205     23.587    -6.663    1.000 25.97539 ?  554 HOH B O   1 
HETATM 4040 O  O   . HOH S 5 .   ? 5.80725   3.44960   -8.29068  1.000 32.57109 ?  555 HOH B O   1 
HETATM 4041 O  O   . HOH S 5 .   ? 23.54754  5.34256   0.68125   1.000 37.34721 ?  556 HOH B O   1 
HETATM 4042 O  O   . HOH S 5 .   ? -6.05171  -3.23641  -6.86357  1.000 30.40981 ?  557 HOH B O   1 
HETATM 4043 O  O   . HOH S 5 .   ? -0.94331  -13.92386 9.10025   1.000 28.13284 ?  558 HOH B O   1 
HETATM 4044 O  O   . HOH S 5 .   ? 3.67223   15.50641  20.90903  1.000 20.12730 ?  559 HOH B O   1 
HETATM 4045 O  O   . HOH S 5 .   ? -4.22791  -10.26343 2.64991   1.000 32.60738 ?  560 HOH B O   1 
HETATM 4046 O  O   . HOH S 5 .   ? 7.62804   -5.60663  19.02062  1.000 42.98726 ?  561 HOH B O   1 
HETATM 4047 O  O   . HOH S 5 .   ? -3.04747  16.19845  10.47335  1.000 33.25190 ?  562 HOH B O   1 
HETATM 4048 O  O   . HOH S 5 .   ? 13.57043  2.68697   17.75387  1.000 6.19376  ?  563 HOH B O   1 
HETATM 4049 O  O   . HOH S 5 .   ? -6.02157  2.45878   21.28622  1.000 33.87181 ?  564 HOH B O   1 
HETATM 4050 O  O   . HOH S 5 .   ? 19.09373  16.06459  4.39246   1.000 28.80261 ?  565 HOH B O   1 
HETATM 4051 O  O   . HOH S 5 .   ? 7.37437   2.37325   10.74946  1.000 24.11823 ?  566 HOH B O   1 
HETATM 4052 O  O   . HOH S 5 .   ? 12.13585  7.97946   23.50108  1.000 27.62220 ?  567 HOH B O   1 
HETATM 4053 O  O   . HOH S 5 .   ? -1.94252  16.07942  13.59723  1.000 34.88824 ?  568 HOH B O   1 
HETATM 4054 O  O   . HOH S 5 .   ? -11.62346 15.65950  7.53258   1.000 35.68350 ?  569 HOH B O   1 
HETATM 4055 O  O   . HOH S 5 .   ? -7.38745  -10.81584 5.28693   1.000 37.44007 ?  570 HOH B O   1 
HETATM 4056 O  O   . HOH S 5 .   ? -0.57303  18.64762  11.62947  1.000 26.04368 ?  571 HOH B O   1 
HETATM 4057 O  O   . HOH S 5 .   ? 17.04538  -0.81040  -13.03207 1.000 35.20626 ?  572 HOH B O   1 
HETATM 4058 O  O   . HOH S 5 .   ? -5.75626  -13.43733 11.55759  1.000 33.98049 ?  573 HOH B O   1 
HETATM 4059 O  O   . HOH S 5 .   ? -11.01168 20.03455  -12.81355 1.000 39.60545 ?  574 HOH B O   1 
HETATM 4060 O  O   . HOH S 5 .   ? 13.26740  1.56422   19.44125  1.000 24.17644 ?  575 HOH B O   1 
HETATM 4061 O  O   . HOH S 5 .   ? 22.52972  1.09678   16.66205  1.000 29.08292 ?  576 HOH B O   1 
HETATM 4062 O  O   . HOH S 5 .   ? 5.03717   7.85992   13.16889  1.000 29.42458 ?  577 HOH B O   1 
HETATM 4063 O  O   . HOH S 5 .   ? -3.82066  -12.38338 1.59682   1.000 36.54037 ?  578 HOH B O   1 
HETATM 4064 O  O   . HOH S 5 .   ? -11.25656 17.74735  9.28641   1.000 48.13599 ?  579 HOH B O   1 
HETATM 4065 O  O   . HOH S 5 .   ? -16.172   -3.907    15.912    1.000 46.08627 ?  580 HOH B O   1 
HETATM 4066 O  O   . HOH S 5 .   ? 19.22244  -11.44676 2.20365   1.000 31.07388 ?  581 HOH B O   1 
HETATM 4067 O  O   . HOH S 5 .   ? -2.52524  8.86509   19.37511  1.000 30.81511 ?  582 HOH B O   1 
HETATM 4068 O  O   . HOH S 5 .   ? 1.005     21.126    -7.995    1.000 37.20017 ?  583 HOH B O   1 
HETATM 4069 O  O   . HOH S 5 .   ? 5.04378   1.31531   24.11898  1.000 35.44817 ?  584 HOH B O   1 
HETATM 4070 O  O   . HOH S 5 .   ? -3.33166  -12.46614 5.79104   1.000 37.23576 ?  585 HOH B O   1 
HETATM 4071 O  O   . HOH S 5 .   ? -5.919    -11.786   -4.315    1.000 38.86907 ?  586 HOH B O   1 
HETATM 4072 O  O   . HOH S 5 .   ? -5.52875  24.51372  1.89663   1.000 24.29275 ?  587 HOH B O   1 
HETATM 4073 O  O   . HOH S 5 .   ? -0.68856  -4.51798  -16.80414 1.000 46.70730 ?  588 HOH B O   1 
HETATM 4074 O  O   . HOH S 5 .   ? 0.81360   22.21315  11.95961  1.000 30.70577 ?  589 HOH B O   1 
HETATM 4075 O  O   . HOH S 5 .   ? 7.45791   14.42063  -8.95556  1.000 34.36201 ?  590 HOH B O   1 
HETATM 4076 O  O   . HOH S 5 .   ? 8.27313   26.34659  4.18162   1.000 33.39488 ?  591 HOH B O   1 
HETATM 4077 O  O   . HOH S 5 .   ? -3.25188  -10.41699 4.72966   1.000 31.66635 ?  592 HOH B O   1 
HETATM 4078 O  O   . HOH S 5 .   ? 5.88476   -4.46056  19.25271  1.000 36.50906 ?  593 HOH B O   1 
HETATM 4079 O  O   . HOH S 5 .   ? 6.146     -10.999   -5.607    1.000 31.82781 ?  594 HOH B O   1 
HETATM 4080 O  O   . HOH S 5 .   ? 11.04524  23.99356  17.97402  1.000 32.55731 ?  595 HOH B O   1 
HETATM 4081 O  O   . HOH S 5 .   ? 12.47288  18.72136  -5.95292  1.000 39.91364 ?  596 HOH B O   1 
HETATM 4082 O  O   . HOH S 5 .   ? 23.12623  2.54824   13.18892  1.000 29.94783 ?  597 HOH B O   1 
HETATM 4083 O  O   . HOH S 5 .   ? -5.68886  1.10248   24.78851  1.000 30.85507 ?  598 HOH B O   1 
HETATM 4084 O  O   . HOH S 5 .   ? 22.84985  13.95383  11.15260  1.000 40.47254 ?  599 HOH B O   1 
HETATM 4085 O  O   . HOH S 5 .   ? -13.06137 11.66373  2.02457   1.000 34.30440 ?  600 HOH B O   1 
HETATM 4086 O  O   . HOH S 5 .   ? 18.05510  0.12843   -11.36407 1.000 27.45395 ?  601 HOH B O   1 
HETATM 4087 O  O   . HOH S 5 .   ? -12.35661 9.89476   11.61016  1.000 33.55743 ?  602 HOH B O   1 
HETATM 4088 O  O   . HOH S 5 .   ? -3.01115  -1.41725  23.42035  1.000 34.52645 ?  603 HOH B O   1 
HETATM 4089 O  O   . HOH S 5 .   ? -12.09099 -4.57494  18.65318  1.000 24.96070 ?  604 HOH B O   1 
HETATM 4090 O  O   . HOH S 5 .   ? 16.52080  20.94075  16.86662  1.000 38.49436 ?  605 HOH B O   1 
HETATM 4091 O  O   . HOH S 5 .   ? -5.62465  19.61082  12.84732  1.000 40.26080 ?  606 HOH B O   1 
HETATM 4092 O  O   . HOH S 5 .   ? -4.43232  10.02329  18.04087  1.000 34.25909 ?  607 HOH B O   1 
HETATM 4093 O  O   . HOH S 5 .   ? 19.02410  18.39706  13.78489  1.000 30.29263 ?  608 HOH B O   1 
HETATM 4094 O  O   . HOH S 5 .   ? 1.01269   -12.86048 15.06611  1.000 37.45797 ?  609 HOH B O   1 
HETATM 4095 O  O   . HOH S 5 .   ? -5.27682  10.92410  15.29116  1.000 26.11819 ?  610 HOH B O   1 
HETATM 4096 O  O   . HOH S 5 .   ? 12.52383  16.55554  26.44820  1.000 28.83771 ?  611 HOH B O   1 
HETATM 4097 O  O   . HOH S 5 .   ? 21.67364  9.61422   6.02300   1.000 27.29863 ?  612 HOH B O   1 
HETATM 4098 O  O   . HOH S 5 .   ? -14.35582 -4.95815  16.82166  1.000 34.96896 ?  613 HOH B O   1 
HETATM 4099 O  O   . HOH S 5 .   ? 14.08988  20.74738  19.96139  1.000 40.44800 ?  614 HOH B O   1 
HETATM 4100 O  O   . HOH S 5 .   ? 20.76236  19.41814  9.56876   1.000 42.16857 ?  615 HOH B O   1 
HETATM 4101 O  O   . HOH S 5 .   ? 1.08219   -5.19352  -18.08653 1.000 40.71674 ?  616 HOH B O   1 
HETATM 4102 O  O   . HOH S 5 .   ? 10.82700  -5.47101  -9.52741  1.000 27.89809 ?  617 HOH B O   1 
HETATM 4103 O  O   . HOH S 5 .   ? 20.80251  -6.91191  12.12599  1.000 35.37413 ?  618 HOH B O   1 
HETATM 4104 O  O   . HOH S 5 .   ? 7.55007   -7.66578  -10.51024 1.000 42.72456 ?  619 HOH B O   1 
HETATM 4105 O  O   . HOH S 5 .   ? 17.89222  2.04945   -13.13783 1.000 31.69603 ?  620 HOH B O   1 
HETATM 4106 O  O   . HOH S 5 .   ? -6.88147  -9.06041  2.78605   1.000 32.77754 ?  621 HOH B O   1 
HETATM 4107 O  O   . HOH S 5 .   ? 4.74749   5.96371   -14.52045 1.000 39.74309 ?  622 HOH B O   1 
HETATM 4108 O  O   . HOH S 5 .   ? 25.04443  10.03113  -0.99830  1.000 45.78282 ?  623 HOH B O   1 
HETATM 4109 O  O   . HOH S 5 .   ? -3.26360  20.63163  16.26277  1.000 34.96049 ?  624 HOH B O   1 
HETATM 4110 O  O   . HOH S 5 .   ? 14.35427  22.98781  18.34758  1.000 40.49092 ?  625 HOH B O   1 
HETATM 4111 O  O   . HOH S 5 .   ? 2.16362   5.53783   -14.53905 1.000 42.72899 ?  626 HOH B O   1 
HETATM 4112 O  O   . HOH S 5 .   ? -7.20292  -15.63845 13.69387  1.000 37.13307 ?  627 HOH B O   1 
# 
