data_9DOD
# 
_entry.id   9DOD 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DOD         pdb_00009dod 10.2210/pdb9dod/pdb 
WWPDB D_1000287333 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-19 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DOD 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              cxu@preludetx.com 
_pdbx_contact_author.name_first         Min 
_pdbx_contact_author.name_last          Wang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0009-0004-9364-1284 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Leal, R.A.'  1 0009-0005-3365-8583 
'Pitis, P.M.' 2 ?                   
'Dou, Y.'     3 0009-0009-4833-234X 
'Lin, H.'     4 ?                   
'Wang, M.'    5 0009-0004-9364-1284 
'Xu, C.'      6 0000-0002-9870-4297 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Leukemia 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1476-5551 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            39 
_citation.language                  ? 
_citation.page_first                765 
_citation.page_last                 769 
_citation.title                     
;Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41375-025-02515-8 
_citation.pdbx_database_id_PubMed   39856223 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bewersdorf, J.P.' 1  ? 
primary 'Mi, X.'           2  ? 
primary 'Lu, B.'           3  ? 
primary 'Kuykendall, A.'   4  ? 
primary 'Sallman, D.'      5  ? 
primary 'Patel, M.'        6  ? 
primary 'Stevens, D.'      7  ? 
primary 'Philipovskiy, A.' 8  ? 
primary 'Sutamtewagul, G.' 9  ? 
primary 'Masarova, L.'     10 ? 
primary 'Keiffer, G.'      11 ? 
primary 'Verma, A.'        12 ? 
primary 'Bhagwat, N.'      13 ? 
primary 'Wang, M.'         14 ? 
primary 'Moore, A.'        15 ? 
primary 'Rager, J.'        16 ? 
primary 'Heiser, D.'       17 ? 
primary 'Ro, S.'           18 ? 
primary 'Hong, W.J.'       19 ? 
primary 'Abdel-Wahab, O.'  20 ? 
primary 'Stein, E.M.'      21 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Protein arginine N-methyltransferase 5'                                                                   
72635.461 1   2.1.1.320 ? ? ? 
2 polymer     man 'Methylosome protein WDR77'                                                                                
36626.051 1   ?         ? ? ? 
3 non-polymer syn '7-[(3xi,5R)-5-C-(3,4-dichlorophenyl)-3-C-methyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine' 
425.266   1   ?         ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                                                                                             
62.068    4   ?         ? ? ? 
5 water       nat water                                                                                                      
18.015    266 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;PRMT5,72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1 homolog,SKB1Hs
;
2 'Androgen receptor cofactor p44,Methylosome protein 50,MEP-50,WD repeat-containing protein 77,p44/Mep50' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTL
IVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPE
DLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKK
GFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLES
QTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTL
ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLY
NEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQ
DITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
;
;AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTL
IVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPE
DLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKK
GFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLES
QTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTL
ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLY
NEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQ
DITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
;
A ? 
2 'polypeptide(L)' no no 
;RKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEA
GVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLS
SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD
TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ
VVHHVVPTEPLPAPGPASVTE
;
;RKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEA
GVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLS
SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD
TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ
VVHHVVPTEPLPAPGPASVTE
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '7-[(3xi,5R)-5-C-(3,4-dichlorophenyl)-3-C-methyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine' A1A79 
4 1,2-ETHANEDIOL                                                                                             EDO   
5 water                                                                                                      HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   ALA n 
1 3   MET n 
1 4   ALA n 
1 5   VAL n 
1 6   GLY n 
1 7   GLY n 
1 8   ALA n 
1 9   GLY n 
1 10  GLY n 
1 11  SER n 
1 12  ARG n 
1 13  VAL n 
1 14  SER n 
1 15  SER n 
1 16  GLY n 
1 17  ARG n 
1 18  ASP n 
1 19  LEU n 
1 20  ASN n 
1 21  CYS n 
1 22  VAL n 
1 23  PRO n 
1 24  GLU n 
1 25  ILE n 
1 26  ALA n 
1 27  ASP n 
1 28  THR n 
1 29  LEU n 
1 30  GLY n 
1 31  ALA n 
1 32  VAL n 
1 33  ALA n 
1 34  LYS n 
1 35  GLN n 
1 36  GLY n 
1 37  PHE n 
1 38  ASP n 
1 39  PHE n 
1 40  LEU n 
1 41  CYS n 
1 42  MET n 
1 43  PRO n 
1 44  VAL n 
1 45  PHE n 
1 46  HIS n 
1 47  PRO n 
1 48  ARG n 
1 49  PHE n 
1 50  LYS n 
1 51  ARG n 
1 52  GLU n 
1 53  PHE n 
1 54  ILE n 
1 55  GLN n 
1 56  GLU n 
1 57  PRO n 
1 58  ALA n 
1 59  LYS n 
1 60  ASN n 
1 61  ARG n 
1 62  PRO n 
1 63  GLY n 
1 64  PRO n 
1 65  GLN n 
1 66  THR n 
1 67  ARG n 
1 68  SER n 
1 69  ASP n 
1 70  LEU n 
1 71  LEU n 
1 72  LEU n 
1 73  SER n 
1 74  GLY n 
1 75  ARG n 
1 76  ASP n 
1 77  TRP n 
1 78  ASN n 
1 79  THR n 
1 80  LEU n 
1 81  ILE n 
1 82  VAL n 
1 83  GLY n 
1 84  LYS n 
1 85  LEU n 
1 86  SER n 
1 87  PRO n 
1 88  TRP n 
1 89  ILE n 
1 90  ARG n 
1 91  PRO n 
1 92  ASP n 
1 93  SER n 
1 94  LYS n 
1 95  VAL n 
1 96  GLU n 
1 97  LYS n 
1 98  ILE n 
1 99  ARG n 
1 100 ARG n 
1 101 ASN n 
1 102 SER n 
1 103 GLU n 
1 104 ALA n 
1 105 ALA n 
1 106 MET n 
1 107 LEU n 
1 108 GLN n 
1 109 GLU n 
1 110 LEU n 
1 111 ASN n 
1 112 PHE n 
1 113 GLY n 
1 114 ALA n 
1 115 TYR n 
1 116 LEU n 
1 117 GLY n 
1 118 LEU n 
1 119 PRO n 
1 120 ALA n 
1 121 PHE n 
1 122 LEU n 
1 123 LEU n 
1 124 PRO n 
1 125 LEU n 
1 126 ASN n 
1 127 GLN n 
1 128 GLU n 
1 129 ASP n 
1 130 ASN n 
1 131 THR n 
1 132 ASN n 
1 133 LEU n 
1 134 ALA n 
1 135 ARG n 
1 136 VAL n 
1 137 LEU n 
1 138 THR n 
1 139 ASN n 
1 140 HIS n 
1 141 ILE n 
1 142 HIS n 
1 143 THR n 
1 144 GLY n 
1 145 HIS n 
1 146 HIS n 
1 147 SER n 
1 148 SER n 
1 149 MET n 
1 150 PHE n 
1 151 TRP n 
1 152 MET n 
1 153 ARG n 
1 154 VAL n 
1 155 PRO n 
1 156 LEU n 
1 157 VAL n 
1 158 ALA n 
1 159 PRO n 
1 160 GLU n 
1 161 ASP n 
1 162 LEU n 
1 163 ARG n 
1 164 ASP n 
1 165 ASP n 
1 166 ILE n 
1 167 ILE n 
1 168 GLU n 
1 169 ASN n 
1 170 ALA n 
1 171 PRO n 
1 172 THR n 
1 173 THR n 
1 174 HIS n 
1 175 THR n 
1 176 GLU n 
1 177 GLU n 
1 178 TYR n 
1 179 SER n 
1 180 GLY n 
1 181 GLU n 
1 182 GLU n 
1 183 LYS n 
1 184 THR n 
1 185 TRP n 
1 186 MET n 
1 187 TRP n 
1 188 TRP n 
1 189 HIS n 
1 190 ASN n 
1 191 PHE n 
1 192 ARG n 
1 193 THR n 
1 194 LEU n 
1 195 CYS n 
1 196 ASP n 
1 197 TYR n 
1 198 SER n 
1 199 LYS n 
1 200 ARG n 
1 201 ILE n 
1 202 ALA n 
1 203 VAL n 
1 204 ALA n 
1 205 LEU n 
1 206 GLU n 
1 207 ILE n 
1 208 GLY n 
1 209 ALA n 
1 210 ASP n 
1 211 LEU n 
1 212 PRO n 
1 213 SER n 
1 214 ASN n 
1 215 HIS n 
1 216 VAL n 
1 217 ILE n 
1 218 ASP n 
1 219 ARG n 
1 220 TRP n 
1 221 LEU n 
1 222 GLY n 
1 223 GLU n 
1 224 PRO n 
1 225 ILE n 
1 226 LYS n 
1 227 ALA n 
1 228 ALA n 
1 229 ILE n 
1 230 LEU n 
1 231 PRO n 
1 232 THR n 
1 233 SER n 
1 234 ILE n 
1 235 PHE n 
1 236 LEU n 
1 237 THR n 
1 238 ASN n 
1 239 LYS n 
1 240 LYS n 
1 241 GLY n 
1 242 PHE n 
1 243 PRO n 
1 244 VAL n 
1 245 LEU n 
1 246 SER n 
1 247 LYS n 
1 248 MET n 
1 249 HIS n 
1 250 GLN n 
1 251 ARG n 
1 252 LEU n 
1 253 ILE n 
1 254 PHE n 
1 255 ARG n 
1 256 LEU n 
1 257 LEU n 
1 258 LYS n 
1 259 LEU n 
1 260 GLU n 
1 261 VAL n 
1 262 GLN n 
1 263 PHE n 
1 264 ILE n 
1 265 ILE n 
1 266 THR n 
1 267 GLY n 
1 268 THR n 
1 269 ASN n 
1 270 HIS n 
1 271 HIS n 
1 272 SER n 
1 273 GLU n 
1 274 LYS n 
1 275 GLU n 
1 276 PHE n 
1 277 CYS n 
1 278 SER n 
1 279 TYR n 
1 280 LEU n 
1 281 GLN n 
1 282 TYR n 
1 283 LEU n 
1 284 GLU n 
1 285 TYR n 
1 286 LEU n 
1 287 SER n 
1 288 GLN n 
1 289 ASN n 
1 290 ARG n 
1 291 PRO n 
1 292 PRO n 
1 293 PRO n 
1 294 ASN n 
1 295 ALA n 
1 296 TYR n 
1 297 GLU n 
1 298 LEU n 
1 299 PHE n 
1 300 ALA n 
1 301 LYS n 
1 302 GLY n 
1 303 TYR n 
1 304 GLU n 
1 305 ASP n 
1 306 TYR n 
1 307 LEU n 
1 308 GLN n 
1 309 SER n 
1 310 PRO n 
1 311 LEU n 
1 312 GLN n 
1 313 PRO n 
1 314 LEU n 
1 315 MET n 
1 316 ASP n 
1 317 ASN n 
1 318 LEU n 
1 319 GLU n 
1 320 SER n 
1 321 GLN n 
1 322 THR n 
1 323 TYR n 
1 324 GLU n 
1 325 VAL n 
1 326 PHE n 
1 327 GLU n 
1 328 LYS n 
1 329 ASP n 
1 330 PRO n 
1 331 ILE n 
1 332 LYS n 
1 333 TYR n 
1 334 SER n 
1 335 GLN n 
1 336 TYR n 
1 337 GLN n 
1 338 GLN n 
1 339 ALA n 
1 340 ILE n 
1 341 TYR n 
1 342 LYS n 
1 343 CYS n 
1 344 LEU n 
1 345 LEU n 
1 346 ASP n 
1 347 ARG n 
1 348 VAL n 
1 349 PRO n 
1 350 GLU n 
1 351 GLU n 
1 352 GLU n 
1 353 LYS n 
1 354 ASP n 
1 355 THR n 
1 356 ASN n 
1 357 VAL n 
1 358 GLN n 
1 359 VAL n 
1 360 LEU n 
1 361 MET n 
1 362 VAL n 
1 363 LEU n 
1 364 GLY n 
1 365 ALA n 
1 366 GLY n 
1 367 ARG n 
1 368 GLY n 
1 369 PRO n 
1 370 LEU n 
1 371 VAL n 
1 372 ASN n 
1 373 ALA n 
1 374 SER n 
1 375 LEU n 
1 376 ARG n 
1 377 ALA n 
1 378 ALA n 
1 379 LYS n 
1 380 GLN n 
1 381 ALA n 
1 382 ASP n 
1 383 ARG n 
1 384 ARG n 
1 385 ILE n 
1 386 LYS n 
1 387 LEU n 
1 388 TYR n 
1 389 ALA n 
1 390 VAL n 
1 391 GLU n 
1 392 LYS n 
1 393 ASN n 
1 394 PRO n 
1 395 ASN n 
1 396 ALA n 
1 397 VAL n 
1 398 VAL n 
1 399 THR n 
1 400 LEU n 
1 401 GLU n 
1 402 ASN n 
1 403 TRP n 
1 404 GLN n 
1 405 PHE n 
1 406 GLU n 
1 407 GLU n 
1 408 TRP n 
1 409 GLY n 
1 410 SER n 
1 411 GLN n 
1 412 VAL n 
1 413 THR n 
1 414 VAL n 
1 415 VAL n 
1 416 SER n 
1 417 SER n 
1 418 ASP n 
1 419 MET n 
1 420 ARG n 
1 421 GLU n 
1 422 TRP n 
1 423 VAL n 
1 424 ALA n 
1 425 PRO n 
1 426 GLU n 
1 427 LYS n 
1 428 ALA n 
1 429 ASP n 
1 430 ILE n 
1 431 ILE n 
1 432 VAL n 
1 433 SER n 
1 434 GLU n 
1 435 LEU n 
1 436 LEU n 
1 437 GLY n 
1 438 SER n 
1 439 PHE n 
1 440 ALA n 
1 441 ASP n 
1 442 ASN n 
1 443 GLU n 
1 444 LEU n 
1 445 SER n 
1 446 PRO n 
1 447 GLU n 
1 448 CYS n 
1 449 LEU n 
1 450 ASP n 
1 451 GLY n 
1 452 ALA n 
1 453 GLN n 
1 454 HIS n 
1 455 PHE n 
1 456 LEU n 
1 457 LYS n 
1 458 ASP n 
1 459 ASP n 
1 460 GLY n 
1 461 VAL n 
1 462 SER n 
1 463 ILE n 
1 464 PRO n 
1 465 GLY n 
1 466 GLU n 
1 467 TYR n 
1 468 THR n 
1 469 SER n 
1 470 PHE n 
1 471 LEU n 
1 472 ALA n 
1 473 PRO n 
1 474 ILE n 
1 475 SER n 
1 476 SER n 
1 477 SER n 
1 478 LYS n 
1 479 LEU n 
1 480 TYR n 
1 481 ASN n 
1 482 GLU n 
1 483 VAL n 
1 484 ARG n 
1 485 ALA n 
1 486 CYS n 
1 487 ARG n 
1 488 GLU n 
1 489 LYS n 
1 490 ASP n 
1 491 ARG n 
1 492 ASP n 
1 493 PRO n 
1 494 GLU n 
1 495 ALA n 
1 496 GLN n 
1 497 PHE n 
1 498 GLU n 
1 499 MET n 
1 500 PRO n 
1 501 TYR n 
1 502 VAL n 
1 503 VAL n 
1 504 ARG n 
1 505 LEU n 
1 506 HIS n 
1 507 ASN n 
1 508 PHE n 
1 509 HIS n 
1 510 GLN n 
1 511 LEU n 
1 512 SER n 
1 513 ALA n 
1 514 PRO n 
1 515 GLN n 
1 516 PRO n 
1 517 CYS n 
1 518 PHE n 
1 519 THR n 
1 520 PHE n 
1 521 SER n 
1 522 HIS n 
1 523 PRO n 
1 524 ASN n 
1 525 ARG n 
1 526 ASP n 
1 527 PRO n 
1 528 MET n 
1 529 ILE n 
1 530 ASP n 
1 531 ASN n 
1 532 ASN n 
1 533 ARG n 
1 534 TYR n 
1 535 CYS n 
1 536 THR n 
1 537 LEU n 
1 538 GLU n 
1 539 PHE n 
1 540 PRO n 
1 541 VAL n 
1 542 GLU n 
1 543 VAL n 
1 544 ASN n 
1 545 THR n 
1 546 VAL n 
1 547 LEU n 
1 548 HIS n 
1 549 GLY n 
1 550 PHE n 
1 551 ALA n 
1 552 GLY n 
1 553 TYR n 
1 554 PHE n 
1 555 GLU n 
1 556 THR n 
1 557 VAL n 
1 558 LEU n 
1 559 TYR n 
1 560 GLN n 
1 561 ASP n 
1 562 ILE n 
1 563 THR n 
1 564 LEU n 
1 565 SER n 
1 566 ILE n 
1 567 ARG n 
1 568 PRO n 
1 569 GLU n 
1 570 THR n 
1 571 HIS n 
1 572 SER n 
1 573 PRO n 
1 574 GLY n 
1 575 MET n 
1 576 PHE n 
1 577 SER n 
1 578 TRP n 
1 579 PHE n 
1 580 PRO n 
1 581 ILE n 
1 582 LEU n 
1 583 PHE n 
1 584 PRO n 
1 585 ILE n 
1 586 LYS n 
1 587 GLN n 
1 588 PRO n 
1 589 ILE n 
1 590 THR n 
1 591 VAL n 
1 592 ARG n 
1 593 GLU n 
1 594 GLY n 
1 595 GLN n 
1 596 THR n 
1 597 ILE n 
1 598 CYS n 
1 599 VAL n 
1 600 ARG n 
1 601 PHE n 
1 602 TRP n 
1 603 ARG n 
1 604 CYS n 
1 605 SER n 
1 606 ASN n 
1 607 SER n 
1 608 LYS n 
1 609 LYS n 
1 610 VAL n 
1 611 TRP n 
1 612 TYR n 
1 613 GLU n 
1 614 TRP n 
1 615 ALA n 
1 616 VAL n 
1 617 THR n 
1 618 ALA n 
1 619 PRO n 
1 620 VAL n 
1 621 CYS n 
1 622 SER n 
1 623 ALA n 
1 624 ILE n 
1 625 HIS n 
1 626 ASN n 
1 627 PRO n 
1 628 THR n 
1 629 GLY n 
1 630 ARG n 
1 631 SER n 
1 632 TYR n 
1 633 THR n 
1 634 ILE n 
1 635 GLY n 
1 636 LEU n 
2 1   ARG n 
2 2   LYS n 
2 3   GLU n 
2 4   THR n 
2 5   PRO n 
2 6   PRO n 
2 7   PRO n 
2 8   LEU n 
2 9   VAL n 
2 10  PRO n 
2 11  PRO n 
2 12  ALA n 
2 13  ALA n 
2 14  ARG n 
2 15  GLU n 
2 16  TRP n 
2 17  ASN n 
2 18  LEU n 
2 19  PRO n 
2 20  PRO n 
2 21  ASN n 
2 22  ALA n 
2 23  PRO n 
2 24  ALA n 
2 25  CYS n 
2 26  MET n 
2 27  GLU n 
2 28  ARG n 
2 29  GLN n 
2 30  LEU n 
2 31  GLU n 
2 32  ALA n 
2 33  ALA n 
2 34  ARG n 
2 35  TYR n 
2 36  ARG n 
2 37  SER n 
2 38  ASP n 
2 39  GLY n 
2 40  ALA n 
2 41  LEU n 
2 42  LEU n 
2 43  LEU n 
2 44  GLY n 
2 45  ALA n 
2 46  SER n 
2 47  SER n 
2 48  LEU n 
2 49  SER n 
2 50  GLY n 
2 51  ARG n 
2 52  CYS n 
2 53  TRP n 
2 54  ALA n 
2 55  GLY n 
2 56  SER n 
2 57  LEU n 
2 58  TRP n 
2 59  LEU n 
2 60  PHE n 
2 61  LYS n 
2 62  ASP n 
2 63  PRO n 
2 64  CYS n 
2 65  ALA n 
2 66  ALA n 
2 67  PRO n 
2 68  ASN n 
2 69  GLU n 
2 70  GLY n 
2 71  PHE n 
2 72  CYS n 
2 73  SER n 
2 74  ALA n 
2 75  GLY n 
2 76  VAL n 
2 77  GLN n 
2 78  THR n 
2 79  GLU n 
2 80  ALA n 
2 81  GLY n 
2 82  VAL n 
2 83  ALA n 
2 84  ASP n 
2 85  LEU n 
2 86  THR n 
2 87  TRP n 
2 88  VAL n 
2 89  GLY n 
2 90  GLU n 
2 91  ARG n 
2 92  GLY n 
2 93  ILE n 
2 94  LEU n 
2 95  VAL n 
2 96  ALA n 
2 97  SER n 
2 98  ASP n 
2 99  SER n 
2 100 GLY n 
2 101 ALA n 
2 102 VAL n 
2 103 GLU n 
2 104 LEU n 
2 105 TRP n 
2 106 GLU n 
2 107 LEU n 
2 108 ASP n 
2 109 GLU n 
2 110 ASN n 
2 111 GLU n 
2 112 THR n 
2 113 LEU n 
2 114 ILE n 
2 115 VAL n 
2 116 SER n 
2 117 LYS n 
2 118 PHE n 
2 119 CYS n 
2 120 LYS n 
2 121 TYR n 
2 122 GLU n 
2 123 HIS n 
2 124 ASP n 
2 125 ASP n 
2 126 ILE n 
2 127 VAL n 
2 128 SER n 
2 129 THR n 
2 130 VAL n 
2 131 SER n 
2 132 VAL n 
2 133 LEU n 
2 134 SER n 
2 135 SER n 
2 136 GLY n 
2 137 THR n 
2 138 GLN n 
2 139 ALA n 
2 140 VAL n 
2 141 SER n 
2 142 GLY n 
2 143 SER n 
2 144 LYS n 
2 145 ASP n 
2 146 ILE n 
2 147 CYS n 
2 148 ILE n 
2 149 LYS n 
2 150 VAL n 
2 151 TRP n 
2 152 ASP n 
2 153 LEU n 
2 154 ALA n 
2 155 GLN n 
2 156 GLN n 
2 157 VAL n 
2 158 VAL n 
2 159 LEU n 
2 160 SER n 
2 161 SER n 
2 162 TYR n 
2 163 ARG n 
2 164 ALA n 
2 165 HIS n 
2 166 ALA n 
2 167 ALA n 
2 168 GLN n 
2 169 VAL n 
2 170 THR n 
2 171 CYS n 
2 172 VAL n 
2 173 ALA n 
2 174 ALA n 
2 175 SER n 
2 176 PRO n 
2 177 HIS n 
2 178 LYS n 
2 179 ASP n 
2 180 SER n 
2 181 VAL n 
2 182 PHE n 
2 183 LEU n 
2 184 SER n 
2 185 CYS n 
2 186 SER n 
2 187 GLU n 
2 188 ASP n 
2 189 ASN n 
2 190 ARG n 
2 191 ILE n 
2 192 LEU n 
2 193 LEU n 
2 194 TRP n 
2 195 ASP n 
2 196 THR n 
2 197 ARG n 
2 198 CYS n 
2 199 PRO n 
2 200 LYS n 
2 201 PRO n 
2 202 ALA n 
2 203 SER n 
2 204 GLN n 
2 205 ILE n 
2 206 GLY n 
2 207 CYS n 
2 208 SER n 
2 209 ALA n 
2 210 PRO n 
2 211 GLY n 
2 212 TYR n 
2 213 LEU n 
2 214 PRO n 
2 215 THR n 
2 216 SER n 
2 217 LEU n 
2 218 ALA n 
2 219 TRP n 
2 220 HIS n 
2 221 PRO n 
2 222 GLN n 
2 223 GLN n 
2 224 SER n 
2 225 GLU n 
2 226 VAL n 
2 227 PHE n 
2 228 VAL n 
2 229 PHE n 
2 230 GLY n 
2 231 ASP n 
2 232 GLU n 
2 233 ASN n 
2 234 GLY n 
2 235 THR n 
2 236 VAL n 
2 237 SER n 
2 238 LEU n 
2 239 VAL n 
2 240 ASP n 
2 241 THR n 
2 242 LYS n 
2 243 SER n 
2 244 THR n 
2 245 SER n 
2 246 CYS n 
2 247 VAL n 
2 248 LEU n 
2 249 SER n 
2 250 SER n 
2 251 ALA n 
2 252 VAL n 
2 253 HIS n 
2 254 SER n 
2 255 GLN n 
2 256 CYS n 
2 257 VAL n 
2 258 THR n 
2 259 GLY n 
2 260 LEU n 
2 261 VAL n 
2 262 PHE n 
2 263 SER n 
2 264 PRO n 
2 265 HIS n 
2 266 SER n 
2 267 VAL n 
2 268 PRO n 
2 269 PHE n 
2 270 LEU n 
2 271 ALA n 
2 272 SER n 
2 273 LEU n 
2 274 SER n 
2 275 GLU n 
2 276 ASP n 
2 277 CYS n 
2 278 SER n 
2 279 LEU n 
2 280 ALA n 
2 281 VAL n 
2 282 LEU n 
2 283 ASP n 
2 284 SER n 
2 285 SER n 
2 286 LEU n 
2 287 SER n 
2 288 GLU n 
2 289 LEU n 
2 290 PHE n 
2 291 ARG n 
2 292 SER n 
2 293 GLN n 
2 294 ALA n 
2 295 HIS n 
2 296 ARG n 
2 297 ASP n 
2 298 PHE n 
2 299 VAL n 
2 300 ARG n 
2 301 ASP n 
2 302 ALA n 
2 303 THR n 
2 304 TRP n 
2 305 SER n 
2 306 PRO n 
2 307 LEU n 
2 308 ASN n 
2 309 HIS n 
2 310 SER n 
2 311 LEU n 
2 312 LEU n 
2 313 THR n 
2 314 THR n 
2 315 VAL n 
2 316 GLY n 
2 317 TRP n 
2 318 ASP n 
2 319 HIS n 
2 320 GLN n 
2 321 VAL n 
2 322 VAL n 
2 323 HIS n 
2 324 HIS n 
2 325 VAL n 
2 326 VAL n 
2 327 PRO n 
2 328 THR n 
2 329 GLU n 
2 330 PRO n 
2 331 LEU n 
2 332 PRO n 
2 333 ALA n 
2 334 PRO n 
2 335 GLY n 
2 336 PRO n 
2 337 ALA n 
2 338 SER n 
2 339 VAL n 
2 340 THR n 
2 341 GLU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 636 human ? 'PRMT5, HRMT1L5, IBP72, JBP1, SKB1'       ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? 'Baculovirus expression vector pFastBac1-HM' 274590 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 341 human ? 'WDR77, MEP50, WD45, HKMT1069, Nbla10071' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? 
? ? ? 'Baculovirus expression vector pFastBac1-HM' 274590 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1A79 non-polymer         . 
'7-[(3xi,5R)-5-C-(3,4-dichlorophenyl)-3-C-methyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine' ?                 
'C18 H18 Cl2 N4 O4' 425.266 
ALA   'L-peptide linking' y ALANINE ?                 'C3 H7 N O2'        89.093  
ARG   'L-peptide linking' y ARGININE ?                 'C6 H15 N4 O2 1'    175.209 
ASN   'L-peptide linking' y ASPARAGINE ?                 'C4 H8 N2 O3'       132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'        133.103 
CYS   'L-peptide linking' y CYSTEINE ?                 'C3 H7 N O2 S'      121.158 
EDO   non-polymer         . 1,2-ETHANEDIOL 'ETHYLENE GLYCOL' 'C2 H6 O2'          62.068  
GLN   'L-peptide linking' y GLUTAMINE ?                 'C5 H10 N2 O3'      146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'        147.129 
GLY   'peptide linking'   y GLYCINE ?                 'C2 H5 N O2'        75.067  
HIS   'L-peptide linking' y HISTIDINE ?                 'C6 H10 N3 O2 1'    156.162 
HOH   non-polymer         . WATER ?                 'H2 O'              18.015  
ILE   'L-peptide linking' y ISOLEUCINE ?                 'C6 H13 N O2'       131.173 
LEU   'L-peptide linking' y LEUCINE ?                 'C6 H13 N O2'       131.173 
LYS   'L-peptide linking' y LYSINE ?                 'C6 H15 N2 O2 1'    147.195 
MET   'L-peptide linking' y METHIONINE ?                 'C5 H11 N O2 S'     149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?                 'C9 H11 N O2'       165.189 
PRO   'L-peptide linking' y PROLINE ?                 'C5 H9 N O2'        115.130 
SER   'L-peptide linking' y SERINE ?                 'C3 H7 N O3'        105.093 
THR   'L-peptide linking' y THREONINE ?                 'C4 H9 N O3'        119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?                 'C11 H12 N2 O2'     204.225 
TYR   'L-peptide linking' y TYROSINE ?                 'C9 H11 N O3'       181.189 
VAL   'L-peptide linking' y VALINE ?                 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   2   ?   ?   ?   A . n 
A 1 2   ALA 2   3   ?   ?   ?   A . n 
A 1 3   MET 3   4   ?   ?   ?   A . n 
A 1 4   ALA 4   5   ?   ?   ?   A . n 
A 1 5   VAL 5   6   ?   ?   ?   A . n 
A 1 6   GLY 6   7   ?   ?   ?   A . n 
A 1 7   GLY 7   8   ?   ?   ?   A . n 
A 1 8   ALA 8   9   ?   ?   ?   A . n 
A 1 9   GLY 9   10  ?   ?   ?   A . n 
A 1 10  GLY 10  11  ?   ?   ?   A . n 
A 1 11  SER 11  12  12  SER SER A . n 
A 1 12  ARG 12  13  13  ARG ARG A . n 
A 1 13  VAL 13  14  14  VAL VAL A . n 
A 1 14  SER 14  15  15  SER SER A . n 
A 1 15  SER 15  16  16  SER SER A . n 
A 1 16  GLY 16  17  17  GLY GLY A . n 
A 1 17  ARG 17  18  18  ARG ARG A . n 
A 1 18  ASP 18  19  19  ASP ASP A . n 
A 1 19  LEU 19  20  20  LEU LEU A . n 
A 1 20  ASN 20  21  21  ASN ASN A . n 
A 1 21  CYS 21  22  22  CYS CYS A . n 
A 1 22  VAL 22  23  23  VAL VAL A . n 
A 1 23  PRO 23  24  24  PRO PRO A . n 
A 1 24  GLU 24  25  25  GLU GLU A . n 
A 1 25  ILE 25  26  26  ILE ILE A . n 
A 1 26  ALA 26  27  27  ALA ALA A . n 
A 1 27  ASP 27  28  28  ASP ASP A . n 
A 1 28  THR 28  29  29  THR THR A . n 
A 1 29  LEU 29  30  30  LEU LEU A . n 
A 1 30  GLY 30  31  31  GLY GLY A . n 
A 1 31  ALA 31  32  32  ALA ALA A . n 
A 1 32  VAL 32  33  33  VAL VAL A . n 
A 1 33  ALA 33  34  34  ALA ALA A . n 
A 1 34  LYS 34  35  35  LYS LYS A . n 
A 1 35  GLN 35  36  36  GLN GLN A . n 
A 1 36  GLY 36  37  37  GLY GLY A . n 
A 1 37  PHE 37  38  38  PHE PHE A . n 
A 1 38  ASP 38  39  39  ASP ASP A . n 
A 1 39  PHE 39  40  40  PHE PHE A . n 
A 1 40  LEU 40  41  41  LEU LEU A . n 
A 1 41  CYS 41  42  42  CYS CYS A . n 
A 1 42  MET 42  43  43  MET MET A . n 
A 1 43  PRO 43  44  44  PRO PRO A . n 
A 1 44  VAL 44  45  45  VAL VAL A . n 
A 1 45  PHE 45  46  46  PHE PHE A . n 
A 1 46  HIS 46  47  47  HIS HIS A . n 
A 1 47  PRO 47  48  48  PRO PRO A . n 
A 1 48  ARG 48  49  49  ARG ARG A . n 
A 1 49  PHE 49  50  50  PHE PHE A . n 
A 1 50  LYS 50  51  51  LYS LYS A . n 
A 1 51  ARG 51  52  52  ARG ARG A . n 
A 1 52  GLU 52  53  53  GLU GLU A . n 
A 1 53  PHE 53  54  54  PHE PHE A . n 
A 1 54  ILE 54  55  55  ILE ILE A . n 
A 1 55  GLN 55  56  56  GLN GLN A . n 
A 1 56  GLU 56  57  57  GLU GLU A . n 
A 1 57  PRO 57  58  58  PRO PRO A . n 
A 1 58  ALA 58  59  59  ALA ALA A . n 
A 1 59  LYS 59  60  60  LYS LYS A . n 
A 1 60  ASN 60  61  61  ASN ASN A . n 
A 1 61  ARG 61  62  62  ARG ARG A . n 
A 1 62  PRO 62  63  63  PRO PRO A . n 
A 1 63  GLY 63  64  64  GLY GLY A . n 
A 1 64  PRO 64  65  65  PRO PRO A . n 
A 1 65  GLN 65  66  66  GLN GLN A . n 
A 1 66  THR 66  67  67  THR THR A . n 
A 1 67  ARG 67  68  68  ARG ARG A . n 
A 1 68  SER 68  69  69  SER SER A . n 
A 1 69  ASP 69  70  70  ASP ASP A . n 
A 1 70  LEU 70  71  71  LEU LEU A . n 
A 1 71  LEU 71  72  72  LEU LEU A . n 
A 1 72  LEU 72  73  73  LEU LEU A . n 
A 1 73  SER 73  74  74  SER SER A . n 
A 1 74  GLY 74  75  75  GLY GLY A . n 
A 1 75  ARG 75  76  76  ARG ARG A . n 
A 1 76  ASP 76  77  77  ASP ASP A . n 
A 1 77  TRP 77  78  78  TRP TRP A . n 
A 1 78  ASN 78  79  79  ASN ASN A . n 
A 1 79  THR 79  80  80  THR THR A . n 
A 1 80  LEU 80  81  81  LEU LEU A . n 
A 1 81  ILE 81  82  82  ILE ILE A . n 
A 1 82  VAL 82  83  83  VAL VAL A . n 
A 1 83  GLY 83  84  84  GLY GLY A . n 
A 1 84  LYS 84  85  85  LYS LYS A . n 
A 1 85  LEU 85  86  86  LEU LEU A . n 
A 1 86  SER 86  87  87  SER SER A . n 
A 1 87  PRO 87  88  88  PRO PRO A . n 
A 1 88  TRP 88  89  89  TRP TRP A . n 
A 1 89  ILE 89  90  90  ILE ILE A . n 
A 1 90  ARG 90  91  91  ARG ARG A . n 
A 1 91  PRO 91  92  92  PRO PRO A . n 
A 1 92  ASP 92  93  93  ASP ASP A . n 
A 1 93  SER 93  94  94  SER SER A . n 
A 1 94  LYS 94  95  95  LYS LYS A . n 
A 1 95  VAL 95  96  96  VAL VAL A . n 
A 1 96  GLU 96  97  97  GLU GLU A . n 
A 1 97  LYS 97  98  98  LYS LYS A . n 
A 1 98  ILE 98  99  99  ILE ILE A . n 
A 1 99  ARG 99  100 100 ARG ARG A . n 
A 1 100 ARG 100 101 101 ARG ARG A . n 
A 1 101 ASN 101 102 102 ASN ASN A . n 
A 1 102 SER 102 103 103 SER SER A . n 
A 1 103 GLU 103 104 104 GLU GLU A . n 
A 1 104 ALA 104 105 105 ALA ALA A . n 
A 1 105 ALA 105 106 106 ALA ALA A . n 
A 1 106 MET 106 107 107 MET MET A . n 
A 1 107 LEU 107 108 108 LEU LEU A . n 
A 1 108 GLN 108 109 109 GLN GLN A . n 
A 1 109 GLU 109 110 110 GLU GLU A . n 
A 1 110 LEU 110 111 111 LEU LEU A . n 
A 1 111 ASN 111 112 112 ASN ASN A . n 
A 1 112 PHE 112 113 113 PHE PHE A . n 
A 1 113 GLY 113 114 114 GLY GLY A . n 
A 1 114 ALA 114 115 115 ALA ALA A . n 
A 1 115 TYR 115 116 116 TYR TYR A . n 
A 1 116 LEU 116 117 117 LEU LEU A . n 
A 1 117 GLY 117 118 118 GLY GLY A . n 
A 1 118 LEU 118 119 119 LEU LEU A . n 
A 1 119 PRO 119 120 120 PRO PRO A . n 
A 1 120 ALA 120 121 121 ALA ALA A . n 
A 1 121 PHE 121 122 122 PHE PHE A . n 
A 1 122 LEU 122 123 123 LEU LEU A . n 
A 1 123 LEU 123 124 124 LEU LEU A . n 
A 1 124 PRO 124 125 125 PRO PRO A . n 
A 1 125 LEU 125 126 126 LEU LEU A . n 
A 1 126 ASN 126 127 127 ASN ASN A . n 
A 1 127 GLN 127 128 128 GLN GLN A . n 
A 1 128 GLU 128 129 129 GLU GLU A . n 
A 1 129 ASP 129 130 130 ASP ASP A . n 
A 1 130 ASN 130 131 131 ASN ASN A . n 
A 1 131 THR 131 132 132 THR THR A . n 
A 1 132 ASN 132 133 133 ASN ASN A . n 
A 1 133 LEU 133 134 134 LEU LEU A . n 
A 1 134 ALA 134 135 135 ALA ALA A . n 
A 1 135 ARG 135 136 136 ARG ARG A . n 
A 1 136 VAL 136 137 137 VAL VAL A . n 
A 1 137 LEU 137 138 138 LEU LEU A . n 
A 1 138 THR 138 139 139 THR THR A . n 
A 1 139 ASN 139 140 140 ASN ASN A . n 
A 1 140 HIS 140 141 141 HIS HIS A . n 
A 1 141 ILE 141 142 142 ILE ILE A . n 
A 1 142 HIS 142 143 143 HIS HIS A . n 
A 1 143 THR 143 144 144 THR THR A . n 
A 1 144 GLY 144 145 145 GLY GLY A . n 
A 1 145 HIS 145 146 146 HIS HIS A . n 
A 1 146 HIS 146 147 147 HIS HIS A . n 
A 1 147 SER 147 148 148 SER SER A . n 
A 1 148 SER 148 149 149 SER SER A . n 
A 1 149 MET 149 150 150 MET MET A . n 
A 1 150 PHE 150 151 151 PHE PHE A . n 
A 1 151 TRP 151 152 152 TRP TRP A . n 
A 1 152 MET 152 153 153 MET MET A . n 
A 1 153 ARG 153 154 154 ARG ARG A . n 
A 1 154 VAL 154 155 155 VAL VAL A . n 
A 1 155 PRO 155 156 156 PRO PRO A . n 
A 1 156 LEU 156 157 157 LEU LEU A . n 
A 1 157 VAL 157 158 158 VAL VAL A . n 
A 1 158 ALA 158 159 159 ALA ALA A . n 
A 1 159 PRO 159 160 160 PRO PRO A . n 
A 1 160 GLU 160 161 161 GLU GLU A . n 
A 1 161 ASP 161 162 162 ASP ASP A . n 
A 1 162 LEU 162 163 163 LEU LEU A . n 
A 1 163 ARG 163 164 164 ARG ARG A . n 
A 1 164 ASP 164 165 165 ASP ASP A . n 
A 1 165 ASP 165 166 166 ASP ASP A . n 
A 1 166 ILE 166 167 167 ILE ILE A . n 
A 1 167 ILE 167 168 168 ILE ILE A . n 
A 1 168 GLU 168 169 169 GLU GLU A . n 
A 1 169 ASN 169 170 170 ASN ASN A . n 
A 1 170 ALA 170 171 171 ALA ALA A . n 
A 1 171 PRO 171 172 172 PRO PRO A . n 
A 1 172 THR 172 173 173 THR THR A . n 
A 1 173 THR 173 174 174 THR THR A . n 
A 1 174 HIS 174 175 175 HIS HIS A . n 
A 1 175 THR 175 176 176 THR THR A . n 
A 1 176 GLU 176 177 177 GLU GLU A . n 
A 1 177 GLU 177 178 178 GLU GLU A . n 
A 1 178 TYR 178 179 179 TYR TYR A . n 
A 1 179 SER 179 180 180 SER SER A . n 
A 1 180 GLY 180 181 181 GLY GLY A . n 
A 1 181 GLU 181 182 182 GLU GLU A . n 
A 1 182 GLU 182 183 183 GLU GLU A . n 
A 1 183 LYS 183 184 184 LYS LYS A . n 
A 1 184 THR 184 185 185 THR THR A . n 
A 1 185 TRP 185 186 186 TRP TRP A . n 
A 1 186 MET 186 187 187 MET MET A . n 
A 1 187 TRP 187 188 188 TRP TRP A . n 
A 1 188 TRP 188 189 189 TRP TRP A . n 
A 1 189 HIS 189 190 190 HIS HIS A . n 
A 1 190 ASN 190 191 191 ASN ASN A . n 
A 1 191 PHE 191 192 192 PHE PHE A . n 
A 1 192 ARG 192 193 193 ARG ARG A . n 
A 1 193 THR 193 194 194 THR THR A . n 
A 1 194 LEU 194 195 195 LEU LEU A . n 
A 1 195 CYS 195 196 196 CYS CYS A . n 
A 1 196 ASP 196 197 197 ASP ASP A . n 
A 1 197 TYR 197 198 198 TYR TYR A . n 
A 1 198 SER 198 199 199 SER SER A . n 
A 1 199 LYS 199 200 200 LYS LYS A . n 
A 1 200 ARG 200 201 201 ARG ARG A . n 
A 1 201 ILE 201 202 202 ILE ILE A . n 
A 1 202 ALA 202 203 203 ALA ALA A . n 
A 1 203 VAL 203 204 204 VAL VAL A . n 
A 1 204 ALA 204 205 205 ALA ALA A . n 
A 1 205 LEU 205 206 206 LEU LEU A . n 
A 1 206 GLU 206 207 207 GLU GLU A . n 
A 1 207 ILE 207 208 208 ILE ILE A . n 
A 1 208 GLY 208 209 209 GLY GLY A . n 
A 1 209 ALA 209 210 210 ALA ALA A . n 
A 1 210 ASP 210 211 211 ASP ASP A . n 
A 1 211 LEU 211 212 212 LEU LEU A . n 
A 1 212 PRO 212 213 213 PRO PRO A . n 
A 1 213 SER 213 214 214 SER SER A . n 
A 1 214 ASN 214 215 215 ASN ASN A . n 
A 1 215 HIS 215 216 216 HIS HIS A . n 
A 1 216 VAL 216 217 217 VAL VAL A . n 
A 1 217 ILE 217 218 218 ILE ILE A . n 
A 1 218 ASP 218 219 219 ASP ASP A . n 
A 1 219 ARG 219 220 220 ARG ARG A . n 
A 1 220 TRP 220 221 221 TRP TRP A . n 
A 1 221 LEU 221 222 222 LEU LEU A . n 
A 1 222 GLY 222 223 223 GLY GLY A . n 
A 1 223 GLU 223 224 224 GLU GLU A . n 
A 1 224 PRO 224 225 225 PRO PRO A . n 
A 1 225 ILE 225 226 226 ILE ILE A . n 
A 1 226 LYS 226 227 227 LYS LYS A . n 
A 1 227 ALA 227 228 228 ALA ALA A . n 
A 1 228 ALA 228 229 229 ALA ALA A . n 
A 1 229 ILE 229 230 230 ILE ILE A . n 
A 1 230 LEU 230 231 231 LEU LEU A . n 
A 1 231 PRO 231 232 232 PRO PRO A . n 
A 1 232 THR 232 233 233 THR THR A . n 
A 1 233 SER 233 234 234 SER SER A . n 
A 1 234 ILE 234 235 235 ILE ILE A . n 
A 1 235 PHE 235 236 236 PHE PHE A . n 
A 1 236 LEU 236 237 237 LEU LEU A . n 
A 1 237 THR 237 238 238 THR THR A . n 
A 1 238 ASN 238 239 239 ASN ASN A . n 
A 1 239 LYS 239 240 240 LYS LYS A . n 
A 1 240 LYS 240 241 241 LYS LYS A . n 
A 1 241 GLY 241 242 242 GLY GLY A . n 
A 1 242 PHE 242 243 243 PHE PHE A . n 
A 1 243 PRO 243 244 244 PRO PRO A . n 
A 1 244 VAL 244 245 245 VAL VAL A . n 
A 1 245 LEU 245 246 246 LEU LEU A . n 
A 1 246 SER 246 247 247 SER SER A . n 
A 1 247 LYS 247 248 248 LYS LYS A . n 
A 1 248 MET 248 249 249 MET MET A . n 
A 1 249 HIS 249 250 250 HIS HIS A . n 
A 1 250 GLN 250 251 251 GLN GLN A . n 
A 1 251 ARG 251 252 252 ARG ARG A . n 
A 1 252 LEU 252 253 253 LEU LEU A . n 
A 1 253 ILE 253 254 254 ILE ILE A . n 
A 1 254 PHE 254 255 255 PHE PHE A . n 
A 1 255 ARG 255 256 256 ARG ARG A . n 
A 1 256 LEU 256 257 257 LEU LEU A . n 
A 1 257 LEU 257 258 258 LEU LEU A . n 
A 1 258 LYS 258 259 259 LYS LYS A . n 
A 1 259 LEU 259 260 260 LEU LEU A . n 
A 1 260 GLU 260 261 261 GLU GLU A . n 
A 1 261 VAL 261 262 262 VAL VAL A . n 
A 1 262 GLN 262 263 263 GLN GLN A . n 
A 1 263 PHE 263 264 264 PHE PHE A . n 
A 1 264 ILE 264 265 265 ILE ILE A . n 
A 1 265 ILE 265 266 266 ILE ILE A . n 
A 1 266 THR 266 267 267 THR THR A . n 
A 1 267 GLY 267 268 268 GLY GLY A . n 
A 1 268 THR 268 269 269 THR THR A . n 
A 1 269 ASN 269 270 270 ASN ASN A . n 
A 1 270 HIS 270 271 271 HIS HIS A . n 
A 1 271 HIS 271 272 272 HIS HIS A . n 
A 1 272 SER 272 273 273 SER SER A . n 
A 1 273 GLU 273 274 274 GLU GLU A . n 
A 1 274 LYS 274 275 275 LYS LYS A . n 
A 1 275 GLU 275 276 276 GLU GLU A . n 
A 1 276 PHE 276 277 277 PHE PHE A . n 
A 1 277 CYS 277 278 278 CYS CYS A . n 
A 1 278 SER 278 279 279 SER SER A . n 
A 1 279 TYR 279 280 280 TYR TYR A . n 
A 1 280 LEU 280 281 281 LEU LEU A . n 
A 1 281 GLN 281 282 282 GLN GLN A . n 
A 1 282 TYR 282 283 283 TYR TYR A . n 
A 1 283 LEU 283 284 284 LEU LEU A . n 
A 1 284 GLU 284 285 285 GLU GLU A . n 
A 1 285 TYR 285 286 286 TYR TYR A . n 
A 1 286 LEU 286 287 287 LEU LEU A . n 
A 1 287 SER 287 288 288 SER SER A . n 
A 1 288 GLN 288 289 289 GLN GLN A . n 
A 1 289 ASN 289 290 290 ASN ASN A . n 
A 1 290 ARG 290 291 291 ARG ARG A . n 
A 1 291 PRO 291 292 292 PRO PRO A . n 
A 1 292 PRO 292 293 293 PRO PRO A . n 
A 1 293 PRO 293 294 294 PRO PRO A . n 
A 1 294 ASN 294 295 295 ASN ASN A . n 
A 1 295 ALA 295 296 296 ALA ALA A . n 
A 1 296 TYR 296 297 297 TYR TYR A . n 
A 1 297 GLU 297 298 298 GLU GLU A . n 
A 1 298 LEU 298 299 299 LEU LEU A . n 
A 1 299 PHE 299 300 300 PHE PHE A . n 
A 1 300 ALA 300 301 301 ALA ALA A . n 
A 1 301 LYS 301 302 302 LYS LYS A . n 
A 1 302 GLY 302 303 303 GLY GLY A . n 
A 1 303 TYR 303 304 304 TYR TYR A . n 
A 1 304 GLU 304 305 305 GLU GLU A . n 
A 1 305 ASP 305 306 306 ASP ASP A . n 
A 1 306 TYR 306 307 307 TYR TYR A . n 
A 1 307 LEU 307 308 308 LEU LEU A . n 
A 1 308 GLN 308 309 309 GLN GLN A . n 
A 1 309 SER 309 310 310 SER SER A . n 
A 1 310 PRO 310 311 311 PRO PRO A . n 
A 1 311 LEU 311 312 312 LEU LEU A . n 
A 1 312 GLN 312 313 313 GLN GLN A . n 
A 1 313 PRO 313 314 314 PRO PRO A . n 
A 1 314 LEU 314 315 315 LEU LEU A . n 
A 1 315 MET 315 316 316 MET MET A . n 
A 1 316 ASP 316 317 317 ASP ASP A . n 
A 1 317 ASN 317 318 318 ASN ASN A . n 
A 1 318 LEU 318 319 319 LEU LEU A . n 
A 1 319 GLU 319 320 320 GLU GLU A . n 
A 1 320 SER 320 321 321 SER SER A . n 
A 1 321 GLN 321 322 322 GLN GLN A . n 
A 1 322 THR 322 323 323 THR THR A . n 
A 1 323 TYR 323 324 324 TYR TYR A . n 
A 1 324 GLU 324 325 325 GLU GLU A . n 
A 1 325 VAL 325 326 326 VAL VAL A . n 
A 1 326 PHE 326 327 327 PHE PHE A . n 
A 1 327 GLU 327 328 328 GLU GLU A . n 
A 1 328 LYS 328 329 329 LYS LYS A . n 
A 1 329 ASP 329 330 330 ASP ASP A . n 
A 1 330 PRO 330 331 331 PRO PRO A . n 
A 1 331 ILE 331 332 332 ILE ILE A . n 
A 1 332 LYS 332 333 333 LYS LYS A . n 
A 1 333 TYR 333 334 334 TYR TYR A . n 
A 1 334 SER 334 335 335 SER SER A . n 
A 1 335 GLN 335 336 336 GLN GLN A . n 
A 1 336 TYR 336 337 337 TYR TYR A . n 
A 1 337 GLN 337 338 338 GLN GLN A . n 
A 1 338 GLN 338 339 339 GLN GLN A . n 
A 1 339 ALA 339 340 340 ALA ALA A . n 
A 1 340 ILE 340 341 341 ILE ILE A . n 
A 1 341 TYR 341 342 342 TYR TYR A . n 
A 1 342 LYS 342 343 343 LYS LYS A . n 
A 1 343 CYS 343 344 344 CYS CYS A . n 
A 1 344 LEU 344 345 345 LEU LEU A . n 
A 1 345 LEU 345 346 346 LEU LEU A . n 
A 1 346 ASP 346 347 347 ASP ASP A . n 
A 1 347 ARG 347 348 348 ARG ARG A . n 
A 1 348 VAL 348 349 349 VAL VAL A . n 
A 1 349 PRO 349 350 350 PRO PRO A . n 
A 1 350 GLU 350 351 351 GLU GLU A . n 
A 1 351 GLU 351 352 352 GLU GLU A . n 
A 1 352 GLU 352 353 353 GLU GLU A . n 
A 1 353 LYS 353 354 354 LYS LYS A . n 
A 1 354 ASP 354 355 355 ASP ASP A . n 
A 1 355 THR 355 356 356 THR THR A . n 
A 1 356 ASN 356 357 357 ASN ASN A . n 
A 1 357 VAL 357 358 358 VAL VAL A . n 
A 1 358 GLN 358 359 359 GLN GLN A . n 
A 1 359 VAL 359 360 360 VAL VAL A . n 
A 1 360 LEU 360 361 361 LEU LEU A . n 
A 1 361 MET 361 362 362 MET MET A . n 
A 1 362 VAL 362 363 363 VAL VAL A . n 
A 1 363 LEU 363 364 364 LEU LEU A . n 
A 1 364 GLY 364 365 365 GLY GLY A . n 
A 1 365 ALA 365 366 366 ALA ALA A . n 
A 1 366 GLY 366 367 367 GLY GLY A . n 
A 1 367 ARG 367 368 368 ARG ARG A . n 
A 1 368 GLY 368 369 369 GLY GLY A . n 
A 1 369 PRO 369 370 370 PRO PRO A . n 
A 1 370 LEU 370 371 371 LEU LEU A . n 
A 1 371 VAL 371 372 372 VAL VAL A . n 
A 1 372 ASN 372 373 373 ASN ASN A . n 
A 1 373 ALA 373 374 374 ALA ALA A . n 
A 1 374 SER 374 375 375 SER SER A . n 
A 1 375 LEU 375 376 376 LEU LEU A . n 
A 1 376 ARG 376 377 377 ARG ARG A . n 
A 1 377 ALA 377 378 378 ALA ALA A . n 
A 1 378 ALA 378 379 379 ALA ALA A . n 
A 1 379 LYS 379 380 380 LYS LYS A . n 
A 1 380 GLN 380 381 381 GLN GLN A . n 
A 1 381 ALA 381 382 382 ALA ALA A . n 
A 1 382 ASP 382 383 383 ASP ASP A . n 
A 1 383 ARG 383 384 384 ARG ARG A . n 
A 1 384 ARG 384 385 385 ARG ARG A . n 
A 1 385 ILE 385 386 386 ILE ILE A . n 
A 1 386 LYS 386 387 387 LYS LYS A . n 
A 1 387 LEU 387 388 388 LEU LEU A . n 
A 1 388 TYR 388 389 389 TYR TYR A . n 
A 1 389 ALA 389 390 390 ALA ALA A . n 
A 1 390 VAL 390 391 391 VAL VAL A . n 
A 1 391 GLU 391 392 392 GLU GLU A . n 
A 1 392 LYS 392 393 393 LYS LYS A . n 
A 1 393 ASN 393 394 394 ASN ASN A . n 
A 1 394 PRO 394 395 395 PRO PRO A . n 
A 1 395 ASN 395 396 396 ASN ASN A . n 
A 1 396 ALA 396 397 397 ALA ALA A . n 
A 1 397 VAL 397 398 398 VAL VAL A . n 
A 1 398 VAL 398 399 399 VAL VAL A . n 
A 1 399 THR 399 400 400 THR THR A . n 
A 1 400 LEU 400 401 401 LEU LEU A . n 
A 1 401 GLU 401 402 402 GLU GLU A . n 
A 1 402 ASN 402 403 403 ASN ASN A . n 
A 1 403 TRP 403 404 404 TRP TRP A . n 
A 1 404 GLN 404 405 405 GLN GLN A . n 
A 1 405 PHE 405 406 406 PHE PHE A . n 
A 1 406 GLU 406 407 407 GLU GLU A . n 
A 1 407 GLU 407 408 408 GLU GLU A . n 
A 1 408 TRP 408 409 409 TRP TRP A . n 
A 1 409 GLY 409 410 410 GLY GLY A . n 
A 1 410 SER 410 411 411 SER SER A . n 
A 1 411 GLN 411 412 412 GLN GLN A . n 
A 1 412 VAL 412 413 413 VAL VAL A . n 
A 1 413 THR 413 414 414 THR THR A . n 
A 1 414 VAL 414 415 415 VAL VAL A . n 
A 1 415 VAL 415 416 416 VAL VAL A . n 
A 1 416 SER 416 417 417 SER SER A . n 
A 1 417 SER 417 418 418 SER SER A . n 
A 1 418 ASP 418 419 419 ASP ASP A . n 
A 1 419 MET 419 420 420 MET MET A . n 
A 1 420 ARG 420 421 421 ARG ARG A . n 
A 1 421 GLU 421 422 422 GLU GLU A . n 
A 1 422 TRP 422 423 423 TRP TRP A . n 
A 1 423 VAL 423 424 424 VAL VAL A . n 
A 1 424 ALA 424 425 425 ALA ALA A . n 
A 1 425 PRO 425 426 426 PRO PRO A . n 
A 1 426 GLU 426 427 427 GLU GLU A . n 
A 1 427 LYS 427 428 428 LYS LYS A . n 
A 1 428 ALA 428 429 429 ALA ALA A . n 
A 1 429 ASP 429 430 430 ASP ASP A . n 
A 1 430 ILE 430 431 431 ILE ILE A . n 
A 1 431 ILE 431 432 432 ILE ILE A . n 
A 1 432 VAL 432 433 433 VAL VAL A . n 
A 1 433 SER 433 434 434 SER SER A . n 
A 1 434 GLU 434 435 435 GLU GLU A . n 
A 1 435 LEU 435 436 436 LEU LEU A . n 
A 1 436 LEU 436 437 437 LEU LEU A . n 
A 1 437 GLY 437 438 438 GLY GLY A . n 
A 1 438 SER 438 439 439 SER SER A . n 
A 1 439 PHE 439 440 440 PHE PHE A . n 
A 1 440 ALA 440 441 441 ALA ALA A . n 
A 1 441 ASP 441 442 442 ASP ASP A . n 
A 1 442 ASN 442 443 443 ASN ASN A . n 
A 1 443 GLU 443 444 444 GLU GLU A . n 
A 1 444 LEU 444 445 445 LEU LEU A . n 
A 1 445 SER 445 446 446 SER SER A . n 
A 1 446 PRO 446 447 447 PRO PRO A . n 
A 1 447 GLU 447 448 448 GLU GLU A . n 
A 1 448 CYS 448 449 449 CYS CYS A . n 
A 1 449 LEU 449 450 450 LEU LEU A . n 
A 1 450 ASP 450 451 451 ASP ASP A . n 
A 1 451 GLY 451 452 452 GLY GLY A . n 
A 1 452 ALA 452 453 453 ALA ALA A . n 
A 1 453 GLN 453 454 454 GLN GLN A . n 
A 1 454 HIS 454 455 455 HIS HIS A . n 
A 1 455 PHE 455 456 456 PHE PHE A . n 
A 1 456 LEU 456 457 457 LEU LEU A . n 
A 1 457 LYS 457 458 458 LYS LYS A . n 
A 1 458 ASP 458 459 459 ASP ASP A . n 
A 1 459 ASP 459 460 460 ASP ASP A . n 
A 1 460 GLY 460 461 461 GLY GLY A . n 
A 1 461 VAL 461 462 462 VAL VAL A . n 
A 1 462 SER 462 463 463 SER SER A . n 
A 1 463 ILE 463 464 464 ILE ILE A . n 
A 1 464 PRO 464 465 465 PRO PRO A . n 
A 1 465 GLY 465 466 466 GLY GLY A . n 
A 1 466 GLU 466 467 467 GLU GLU A . n 
A 1 467 TYR 467 468 468 TYR TYR A . n 
A 1 468 THR 468 469 469 THR THR A . n 
A 1 469 SER 469 470 470 SER SER A . n 
A 1 470 PHE 470 471 471 PHE PHE A . n 
A 1 471 LEU 471 472 472 LEU LEU A . n 
A 1 472 ALA 472 473 473 ALA ALA A . n 
A 1 473 PRO 473 474 474 PRO PRO A . n 
A 1 474 ILE 474 475 475 ILE ILE A . n 
A 1 475 SER 475 476 476 SER SER A . n 
A 1 476 SER 476 477 477 SER SER A . n 
A 1 477 SER 477 478 478 SER SER A . n 
A 1 478 LYS 478 479 479 LYS LYS A . n 
A 1 479 LEU 479 480 480 LEU LEU A . n 
A 1 480 TYR 480 481 481 TYR TYR A . n 
A 1 481 ASN 481 482 482 ASN ASN A . n 
A 1 482 GLU 482 483 483 GLU GLU A . n 
A 1 483 VAL 483 484 484 VAL VAL A . n 
A 1 484 ARG 484 485 485 ARG ARG A . n 
A 1 485 ALA 485 486 486 ALA ALA A . n 
A 1 486 CYS 486 487 487 CYS CYS A . n 
A 1 487 ARG 487 488 488 ARG ARG A . n 
A 1 488 GLU 488 489 489 GLU GLU A . n 
A 1 489 LYS 489 490 490 LYS LYS A . n 
A 1 490 ASP 490 491 491 ASP ASP A . n 
A 1 491 ARG 491 492 492 ARG ARG A . n 
A 1 492 ASP 492 493 493 ASP ASP A . n 
A 1 493 PRO 493 494 494 PRO PRO A . n 
A 1 494 GLU 494 495 495 GLU GLU A . n 
A 1 495 ALA 495 496 496 ALA ALA A . n 
A 1 496 GLN 496 497 497 GLN GLN A . n 
A 1 497 PHE 497 498 498 PHE PHE A . n 
A 1 498 GLU 498 499 499 GLU GLU A . n 
A 1 499 MET 499 500 500 MET MET A . n 
A 1 500 PRO 500 501 501 PRO PRO A . n 
A 1 501 TYR 501 502 502 TYR TYR A . n 
A 1 502 VAL 502 503 503 VAL VAL A . n 
A 1 503 VAL 503 504 504 VAL VAL A . n 
A 1 504 ARG 504 505 505 ARG ARG A . n 
A 1 505 LEU 505 506 506 LEU LEU A . n 
A 1 506 HIS 506 507 507 HIS HIS A . n 
A 1 507 ASN 507 508 508 ASN ASN A . n 
A 1 508 PHE 508 509 509 PHE PHE A . n 
A 1 509 HIS 509 510 510 HIS HIS A . n 
A 1 510 GLN 510 511 511 GLN GLN A . n 
A 1 511 LEU 511 512 512 LEU LEU A . n 
A 1 512 SER 512 513 513 SER SER A . n 
A 1 513 ALA 513 514 514 ALA ALA A . n 
A 1 514 PRO 514 515 515 PRO PRO A . n 
A 1 515 GLN 515 516 516 GLN GLN A . n 
A 1 516 PRO 516 517 517 PRO PRO A . n 
A 1 517 CYS 517 518 518 CYS CYS A . n 
A 1 518 PHE 518 519 519 PHE PHE A . n 
A 1 519 THR 519 520 520 THR THR A . n 
A 1 520 PHE 520 521 521 PHE PHE A . n 
A 1 521 SER 521 522 522 SER SER A . n 
A 1 522 HIS 522 523 523 HIS HIS A . n 
A 1 523 PRO 523 524 524 PRO PRO A . n 
A 1 524 ASN 524 525 525 ASN ASN A . n 
A 1 525 ARG 525 526 526 ARG ARG A . n 
A 1 526 ASP 526 527 527 ASP ASP A . n 
A 1 527 PRO 527 528 528 PRO PRO A . n 
A 1 528 MET 528 529 529 MET MET A . n 
A 1 529 ILE 529 530 530 ILE ILE A . n 
A 1 530 ASP 530 531 531 ASP ASP A . n 
A 1 531 ASN 531 532 532 ASN ASN A . n 
A 1 532 ASN 532 533 533 ASN ASN A . n 
A 1 533 ARG 533 534 534 ARG ARG A . n 
A 1 534 TYR 534 535 535 TYR TYR A . n 
A 1 535 CYS 535 536 536 CYS CYS A . n 
A 1 536 THR 536 537 537 THR THR A . n 
A 1 537 LEU 537 538 538 LEU LEU A . n 
A 1 538 GLU 538 539 539 GLU GLU A . n 
A 1 539 PHE 539 540 540 PHE PHE A . n 
A 1 540 PRO 540 541 541 PRO PRO A . n 
A 1 541 VAL 541 542 542 VAL VAL A . n 
A 1 542 GLU 542 543 543 GLU GLU A . n 
A 1 543 VAL 543 544 544 VAL VAL A . n 
A 1 544 ASN 544 545 545 ASN ASN A . n 
A 1 545 THR 545 546 546 THR THR A . n 
A 1 546 VAL 546 547 547 VAL VAL A . n 
A 1 547 LEU 547 548 548 LEU LEU A . n 
A 1 548 HIS 548 549 549 HIS HIS A . n 
A 1 549 GLY 549 550 550 GLY GLY A . n 
A 1 550 PHE 550 551 551 PHE PHE A . n 
A 1 551 ALA 551 552 552 ALA ALA A . n 
A 1 552 GLY 552 553 553 GLY GLY A . n 
A 1 553 TYR 553 554 554 TYR TYR A . n 
A 1 554 PHE 554 555 555 PHE PHE A . n 
A 1 555 GLU 555 556 556 GLU GLU A . n 
A 1 556 THR 556 557 557 THR THR A . n 
A 1 557 VAL 557 558 558 VAL VAL A . n 
A 1 558 LEU 558 559 559 LEU LEU A . n 
A 1 559 TYR 559 560 560 TYR TYR A . n 
A 1 560 GLN 560 561 561 GLN GLN A . n 
A 1 561 ASP 561 562 562 ASP ASP A . n 
A 1 562 ILE 562 563 563 ILE ILE A . n 
A 1 563 THR 563 564 564 THR THR A . n 
A 1 564 LEU 564 565 565 LEU LEU A . n 
A 1 565 SER 565 566 566 SER SER A . n 
A 1 566 ILE 566 567 567 ILE ILE A . n 
A 1 567 ARG 567 568 568 ARG ARG A . n 
A 1 568 PRO 568 569 569 PRO PRO A . n 
A 1 569 GLU 569 570 570 GLU GLU A . n 
A 1 570 THR 570 571 571 THR THR A . n 
A 1 571 HIS 571 572 572 HIS HIS A . n 
A 1 572 SER 572 573 573 SER SER A . n 
A 1 573 PRO 573 574 574 PRO PRO A . n 
A 1 574 GLY 574 575 575 GLY GLY A . n 
A 1 575 MET 575 576 576 MET MET A . n 
A 1 576 PHE 576 577 577 PHE PHE A . n 
A 1 577 SER 577 578 578 SER SER A . n 
A 1 578 TRP 578 579 579 TRP TRP A . n 
A 1 579 PHE 579 580 580 PHE PHE A . n 
A 1 580 PRO 580 581 581 PRO PRO A . n 
A 1 581 ILE 581 582 582 ILE ILE A . n 
A 1 582 LEU 582 583 583 LEU LEU A . n 
A 1 583 PHE 583 584 584 PHE PHE A . n 
A 1 584 PRO 584 585 585 PRO PRO A . n 
A 1 585 ILE 585 586 586 ILE ILE A . n 
A 1 586 LYS 586 587 587 LYS LYS A . n 
A 1 587 GLN 587 588 588 GLN GLN A . n 
A 1 588 PRO 588 589 589 PRO PRO A . n 
A 1 589 ILE 589 590 590 ILE ILE A . n 
A 1 590 THR 590 591 591 THR THR A . n 
A 1 591 VAL 591 592 592 VAL VAL A . n 
A 1 592 ARG 592 593 593 ARG ARG A . n 
A 1 593 GLU 593 594 594 GLU GLU A . n 
A 1 594 GLY 594 595 595 GLY GLY A . n 
A 1 595 GLN 595 596 596 GLN GLN A . n 
A 1 596 THR 596 597 597 THR THR A . n 
A 1 597 ILE 597 598 598 ILE ILE A . n 
A 1 598 CYS 598 599 599 CYS CYS A . n 
A 1 599 VAL 599 600 600 VAL VAL A . n 
A 1 600 ARG 600 601 601 ARG ARG A . n 
A 1 601 PHE 601 602 602 PHE PHE A . n 
A 1 602 TRP 602 603 603 TRP TRP A . n 
A 1 603 ARG 603 604 604 ARG ARG A . n 
A 1 604 CYS 604 605 605 CYS CYS A . n 
A 1 605 SER 605 606 606 SER SER A . n 
A 1 606 ASN 606 607 607 ASN ASN A . n 
A 1 607 SER 607 608 608 SER SER A . n 
A 1 608 LYS 608 609 609 LYS LYS A . n 
A 1 609 LYS 609 610 610 LYS LYS A . n 
A 1 610 VAL 610 611 611 VAL VAL A . n 
A 1 611 TRP 611 612 612 TRP TRP A . n 
A 1 612 TYR 612 613 613 TYR TYR A . n 
A 1 613 GLU 613 614 614 GLU GLU A . n 
A 1 614 TRP 614 615 615 TRP TRP A . n 
A 1 615 ALA 615 616 616 ALA ALA A . n 
A 1 616 VAL 616 617 617 VAL VAL A . n 
A 1 617 THR 617 618 618 THR THR A . n 
A 1 618 ALA 618 619 619 ALA ALA A . n 
A 1 619 PRO 619 620 620 PRO PRO A . n 
A 1 620 VAL 620 621 621 VAL VAL A . n 
A 1 621 CYS 621 622 622 CYS CYS A . n 
A 1 622 SER 622 623 623 SER SER A . n 
A 1 623 ALA 623 624 624 ALA ALA A . n 
A 1 624 ILE 624 625 625 ILE ILE A . n 
A 1 625 HIS 625 626 626 HIS HIS A . n 
A 1 626 ASN 626 627 627 ASN ASN A . n 
A 1 627 PRO 627 628 628 PRO PRO A . n 
A 1 628 THR 628 629 629 THR THR A . n 
A 1 629 GLY 629 630 630 GLY GLY A . n 
A 1 630 ARG 630 631 631 ARG ARG A . n 
A 1 631 SER 631 632 632 SER SER A . n 
A 1 632 TYR 632 633 633 TYR TYR A . n 
A 1 633 THR 633 634 634 THR THR A . n 
A 1 634 ILE 634 635 635 ILE ILE A . n 
A 1 635 GLY 635 636 636 GLY GLY A . n 
A 1 636 LEU 636 637 637 LEU LEU A . n 
B 2 1   ARG 1   2   ?   ?   ?   B . n 
B 2 2   LYS 2   3   ?   ?   ?   B . n 
B 2 3   GLU 3   4   ?   ?   ?   B . n 
B 2 4   THR 4   5   ?   ?   ?   B . n 
B 2 5   PRO 5   6   ?   ?   ?   B . n 
B 2 6   PRO 6   7   ?   ?   ?   B . n 
B 2 7   PRO 7   8   ?   ?   ?   B . n 
B 2 8   LEU 8   9   ?   ?   ?   B . n 
B 2 9   VAL 9   10  ?   ?   ?   B . n 
B 2 10  PRO 10  11  ?   ?   ?   B . n 
B 2 11  PRO 11  12  ?   ?   ?   B . n 
B 2 12  ALA 12  13  ?   ?   ?   B . n 
B 2 13  ALA 13  14  ?   ?   ?   B . n 
B 2 14  ARG 14  15  ?   ?   ?   B . n 
B 2 15  GLU 15  16  ?   ?   ?   B . n 
B 2 16  TRP 16  17  ?   ?   ?   B . n 
B 2 17  ASN 17  18  18  ASN ASN B . n 
B 2 18  LEU 18  19  19  LEU LEU B . n 
B 2 19  PRO 19  20  20  PRO PRO B . n 
B 2 20  PRO 20  21  21  PRO PRO B . n 
B 2 21  ASN 21  22  22  ASN ASN B . n 
B 2 22  ALA 22  23  23  ALA ALA B . n 
B 2 23  PRO 23  24  24  PRO PRO B . n 
B 2 24  ALA 24  25  25  ALA ALA B . n 
B 2 25  CYS 25  26  26  CYS CYS B . n 
B 2 26  MET 26  27  27  MET MET B . n 
B 2 27  GLU 27  28  28  GLU GLU B . n 
B 2 28  ARG 28  29  29  ARG ARG B . n 
B 2 29  GLN 29  30  30  GLN GLN B . n 
B 2 30  LEU 30  31  31  LEU LEU B . n 
B 2 31  GLU 31  32  32  GLU GLU B . n 
B 2 32  ALA 32  33  33  ALA ALA B . n 
B 2 33  ALA 33  34  34  ALA ALA B . n 
B 2 34  ARG 34  35  35  ARG ARG B . n 
B 2 35  TYR 35  36  36  TYR TYR B . n 
B 2 36  ARG 36  37  37  ARG ARG B . n 
B 2 37  SER 37  38  38  SER SER B . n 
B 2 38  ASP 38  39  39  ASP ASP B . n 
B 2 39  GLY 39  40  40  GLY GLY B . n 
B 2 40  ALA 40  41  41  ALA ALA B . n 
B 2 41  LEU 41  42  42  LEU LEU B . n 
B 2 42  LEU 42  43  43  LEU LEU B . n 
B 2 43  LEU 43  44  44  LEU LEU B . n 
B 2 44  GLY 44  45  45  GLY GLY B . n 
B 2 45  ALA 45  46  46  ALA ALA B . n 
B 2 46  SER 46  47  47  SER SER B . n 
B 2 47  SER 47  48  48  SER SER B . n 
B 2 48  LEU 48  49  49  LEU LEU B . n 
B 2 49  SER 49  50  50  SER SER B . n 
B 2 50  GLY 50  51  51  GLY GLY B . n 
B 2 51  ARG 51  52  52  ARG ARG B . n 
B 2 52  CYS 52  53  53  CYS CYS B . n 
B 2 53  TRP 53  54  54  TRP TRP B . n 
B 2 54  ALA 54  55  55  ALA ALA B . n 
B 2 55  GLY 55  56  56  GLY GLY B . n 
B 2 56  SER 56  57  57  SER SER B . n 
B 2 57  LEU 57  58  58  LEU LEU B . n 
B 2 58  TRP 58  59  59  TRP TRP B . n 
B 2 59  LEU 59  60  60  LEU LEU B . n 
B 2 60  PHE 60  61  61  PHE PHE B . n 
B 2 61  LYS 61  62  62  LYS LYS B . n 
B 2 62  ASP 62  63  63  ASP ASP B . n 
B 2 63  PRO 63  64  64  PRO PRO B . n 
B 2 64  CYS 64  65  65  CYS CYS B . n 
B 2 65  ALA 65  66  66  ALA ALA B . n 
B 2 66  ALA 66  67  67  ALA ALA B . n 
B 2 67  PRO 67  68  68  PRO PRO B . n 
B 2 68  ASN 68  69  69  ASN ASN B . n 
B 2 69  GLU 69  70  70  GLU GLU B . n 
B 2 70  GLY 70  71  71  GLY GLY B . n 
B 2 71  PHE 71  72  72  PHE PHE B . n 
B 2 72  CYS 72  73  73  CYS CYS B . n 
B 2 73  SER 73  74  74  SER SER B . n 
B 2 74  ALA 74  75  75  ALA ALA B . n 
B 2 75  GLY 75  76  76  GLY GLY B . n 
B 2 76  VAL 76  77  77  VAL VAL B . n 
B 2 77  GLN 77  78  78  GLN GLN B . n 
B 2 78  THR 78  79  79  THR THR B . n 
B 2 79  GLU 79  80  80  GLU GLU B . n 
B 2 80  ALA 80  81  81  ALA ALA B . n 
B 2 81  GLY 81  82  82  GLY GLY B . n 
B 2 82  VAL 82  83  83  VAL VAL B . n 
B 2 83  ALA 83  84  84  ALA ALA B . n 
B 2 84  ASP 84  85  85  ASP ASP B . n 
B 2 85  LEU 85  86  86  LEU LEU B . n 
B 2 86  THR 86  87  87  THR THR B . n 
B 2 87  TRP 87  88  88  TRP TRP B . n 
B 2 88  VAL 88  89  89  VAL VAL B . n 
B 2 89  GLY 89  90  90  GLY GLY B . n 
B 2 90  GLU 90  91  91  GLU GLU B . n 
B 2 91  ARG 91  92  92  ARG ARG B . n 
B 2 92  GLY 92  93  93  GLY GLY B . n 
B 2 93  ILE 93  94  94  ILE ILE B . n 
B 2 94  LEU 94  95  95  LEU LEU B . n 
B 2 95  VAL 95  96  96  VAL VAL B . n 
B 2 96  ALA 96  97  97  ALA ALA B . n 
B 2 97  SER 97  98  98  SER SER B . n 
B 2 98  ASP 98  99  99  ASP ASP B . n 
B 2 99  SER 99  100 100 SER SER B . n 
B 2 100 GLY 100 101 101 GLY GLY B . n 
B 2 101 ALA 101 102 102 ALA ALA B . n 
B 2 102 VAL 102 103 103 VAL VAL B . n 
B 2 103 GLU 103 104 104 GLU GLU B . n 
B 2 104 LEU 104 105 105 LEU LEU B . n 
B 2 105 TRP 105 106 106 TRP TRP B . n 
B 2 106 GLU 106 107 107 GLU GLU B . n 
B 2 107 LEU 107 108 108 LEU LEU B . n 
B 2 108 ASP 108 109 109 ASP ASP B . n 
B 2 109 GLU 109 110 110 GLU GLU B . n 
B 2 110 ASN 110 111 111 ASN ASN B . n 
B 2 111 GLU 111 112 112 GLU GLU B . n 
B 2 112 THR 112 113 113 THR THR B . n 
B 2 113 LEU 113 114 114 LEU LEU B . n 
B 2 114 ILE 114 115 115 ILE ILE B . n 
B 2 115 VAL 115 116 116 VAL VAL B . n 
B 2 116 SER 116 117 117 SER SER B . n 
B 2 117 LYS 117 118 118 LYS LYS B . n 
B 2 118 PHE 118 119 119 PHE PHE B . n 
B 2 119 CYS 119 120 120 CYS CYS B . n 
B 2 120 LYS 120 121 121 LYS LYS B . n 
B 2 121 TYR 121 122 122 TYR TYR B . n 
B 2 122 GLU 122 123 123 GLU GLU B . n 
B 2 123 HIS 123 124 124 HIS HIS B . n 
B 2 124 ASP 124 125 125 ASP ASP B . n 
B 2 125 ASP 125 126 126 ASP ASP B . n 
B 2 126 ILE 126 127 127 ILE ILE B . n 
B 2 127 VAL 127 128 128 VAL VAL B . n 
B 2 128 SER 128 129 129 SER SER B . n 
B 2 129 THR 129 130 130 THR THR B . n 
B 2 130 VAL 130 131 131 VAL VAL B . n 
B 2 131 SER 131 132 132 SER SER B . n 
B 2 132 VAL 132 133 133 VAL VAL B . n 
B 2 133 LEU 133 134 134 LEU LEU B . n 
B 2 134 SER 134 135 135 SER SER B . n 
B 2 135 SER 135 136 136 SER SER B . n 
B 2 136 GLY 136 137 137 GLY GLY B . n 
B 2 137 THR 137 138 138 THR THR B . n 
B 2 138 GLN 138 139 139 GLN GLN B . n 
B 2 139 ALA 139 140 140 ALA ALA B . n 
B 2 140 VAL 140 141 141 VAL VAL B . n 
B 2 141 SER 141 142 142 SER SER B . n 
B 2 142 GLY 142 143 143 GLY GLY B . n 
B 2 143 SER 143 144 144 SER SER B . n 
B 2 144 LYS 144 145 145 LYS LYS B . n 
B 2 145 ASP 145 146 146 ASP ASP B . n 
B 2 146 ILE 146 147 147 ILE ILE B . n 
B 2 147 CYS 147 148 148 CYS CYS B . n 
B 2 148 ILE 148 149 149 ILE ILE B . n 
B 2 149 LYS 149 150 150 LYS LYS B . n 
B 2 150 VAL 150 151 151 VAL VAL B . n 
B 2 151 TRP 151 152 152 TRP TRP B . n 
B 2 152 ASP 152 153 153 ASP ASP B . n 
B 2 153 LEU 153 154 154 LEU LEU B . n 
B 2 154 ALA 154 155 155 ALA ALA B . n 
B 2 155 GLN 155 156 156 GLN GLN B . n 
B 2 156 GLN 156 157 157 GLN GLN B . n 
B 2 157 VAL 157 158 158 VAL VAL B . n 
B 2 158 VAL 158 159 159 VAL VAL B . n 
B 2 159 LEU 159 160 160 LEU LEU B . n 
B 2 160 SER 160 161 161 SER SER B . n 
B 2 161 SER 161 162 162 SER SER B . n 
B 2 162 TYR 162 163 163 TYR TYR B . n 
B 2 163 ARG 163 164 164 ARG ARG B . n 
B 2 164 ALA 164 165 165 ALA ALA B . n 
B 2 165 HIS 165 166 166 HIS HIS B . n 
B 2 166 ALA 166 167 167 ALA ALA B . n 
B 2 167 ALA 167 168 168 ALA ALA B . n 
B 2 168 GLN 168 169 169 GLN GLN B . n 
B 2 169 VAL 169 170 170 VAL VAL B . n 
B 2 170 THR 170 171 171 THR THR B . n 
B 2 171 CYS 171 172 172 CYS CYS B . n 
B 2 172 VAL 172 173 173 VAL VAL B . n 
B 2 173 ALA 173 174 174 ALA ALA B . n 
B 2 174 ALA 174 175 175 ALA ALA B . n 
B 2 175 SER 175 176 176 SER SER B . n 
B 2 176 PRO 176 177 177 PRO PRO B . n 
B 2 177 HIS 177 178 178 HIS HIS B . n 
B 2 178 LYS 178 179 179 LYS LYS B . n 
B 2 179 ASP 179 180 180 ASP ASP B . n 
B 2 180 SER 180 181 181 SER SER B . n 
B 2 181 VAL 181 182 182 VAL VAL B . n 
B 2 182 PHE 182 183 183 PHE PHE B . n 
B 2 183 LEU 183 184 184 LEU LEU B . n 
B 2 184 SER 184 185 185 SER SER B . n 
B 2 185 CYS 185 186 186 CYS CYS B . n 
B 2 186 SER 186 187 187 SER SER B . n 
B 2 187 GLU 187 188 188 GLU GLU B . n 
B 2 188 ASP 188 189 189 ASP ASP B . n 
B 2 189 ASN 189 190 190 ASN ASN B . n 
B 2 190 ARG 190 191 191 ARG ARG B . n 
B 2 191 ILE 191 192 192 ILE ILE B . n 
B 2 192 LEU 192 193 193 LEU LEU B . n 
B 2 193 LEU 193 194 194 LEU LEU B . n 
B 2 194 TRP 194 195 195 TRP TRP B . n 
B 2 195 ASP 195 196 196 ASP ASP B . n 
B 2 196 THR 196 197 197 THR THR B . n 
B 2 197 ARG 197 198 198 ARG ARG B . n 
B 2 198 CYS 198 199 199 CYS CYS B . n 
B 2 199 PRO 199 200 200 PRO PRO B . n 
B 2 200 LYS 200 201 201 LYS LYS B . n 
B 2 201 PRO 201 202 202 PRO PRO B . n 
B 2 202 ALA 202 203 203 ALA ALA B . n 
B 2 203 SER 203 204 204 SER SER B . n 
B 2 204 GLN 204 205 205 GLN GLN B . n 
B 2 205 ILE 205 206 206 ILE ILE B . n 
B 2 206 GLY 206 207 207 GLY GLY B . n 
B 2 207 CYS 207 208 208 CYS CYS B . n 
B 2 208 SER 208 209 209 SER SER B . n 
B 2 209 ALA 209 210 210 ALA ALA B . n 
B 2 210 PRO 210 211 211 PRO PRO B . n 
B 2 211 GLY 211 212 212 GLY GLY B . n 
B 2 212 TYR 212 213 213 TYR TYR B . n 
B 2 213 LEU 213 214 214 LEU LEU B . n 
B 2 214 PRO 214 215 215 PRO PRO B . n 
B 2 215 THR 215 216 216 THR THR B . n 
B 2 216 SER 216 217 217 SER SER B . n 
B 2 217 LEU 217 218 218 LEU LEU B . n 
B 2 218 ALA 218 219 219 ALA ALA B . n 
B 2 219 TRP 219 220 220 TRP TRP B . n 
B 2 220 HIS 220 221 221 HIS HIS B . n 
B 2 221 PRO 221 222 222 PRO PRO B . n 
B 2 222 GLN 222 223 223 GLN GLN B . n 
B 2 223 GLN 223 224 224 GLN GLN B . n 
B 2 224 SER 224 225 225 SER SER B . n 
B 2 225 GLU 225 226 226 GLU GLU B . n 
B 2 226 VAL 226 227 227 VAL VAL B . n 
B 2 227 PHE 227 228 228 PHE PHE B . n 
B 2 228 VAL 228 229 229 VAL VAL B . n 
B 2 229 PHE 229 230 230 PHE PHE B . n 
B 2 230 GLY 230 231 231 GLY GLY B . n 
B 2 231 ASP 231 232 232 ASP ASP B . n 
B 2 232 GLU 232 233 233 GLU GLU B . n 
B 2 233 ASN 233 234 234 ASN ASN B . n 
B 2 234 GLY 234 235 235 GLY GLY B . n 
B 2 235 THR 235 236 236 THR THR B . n 
B 2 236 VAL 236 237 237 VAL VAL B . n 
B 2 237 SER 237 238 238 SER SER B . n 
B 2 238 LEU 238 239 239 LEU LEU B . n 
B 2 239 VAL 239 240 240 VAL VAL B . n 
B 2 240 ASP 240 241 241 ASP ASP B . n 
B 2 241 THR 241 242 242 THR THR B . n 
B 2 242 LYS 242 243 243 LYS LYS B . n 
B 2 243 SER 243 244 244 SER SER B . n 
B 2 244 THR 244 245 245 THR THR B . n 
B 2 245 SER 245 246 246 SER SER B . n 
B 2 246 CYS 246 247 247 CYS CYS B . n 
B 2 247 VAL 247 248 248 VAL VAL B . n 
B 2 248 LEU 248 249 249 LEU LEU B . n 
B 2 249 SER 249 250 250 SER SER B . n 
B 2 250 SER 250 251 251 SER SER B . n 
B 2 251 ALA 251 252 252 ALA ALA B . n 
B 2 252 VAL 252 253 253 VAL VAL B . n 
B 2 253 HIS 253 254 254 HIS HIS B . n 
B 2 254 SER 254 255 255 SER SER B . n 
B 2 255 GLN 255 256 256 GLN GLN B . n 
B 2 256 CYS 256 257 257 CYS CYS B . n 
B 2 257 VAL 257 258 258 VAL VAL B . n 
B 2 258 THR 258 259 259 THR THR B . n 
B 2 259 GLY 259 260 260 GLY GLY B . n 
B 2 260 LEU 260 261 261 LEU LEU B . n 
B 2 261 VAL 261 262 262 VAL VAL B . n 
B 2 262 PHE 262 263 263 PHE PHE B . n 
B 2 263 SER 263 264 264 SER SER B . n 
B 2 264 PRO 264 265 265 PRO PRO B . n 
B 2 265 HIS 265 266 266 HIS HIS B . n 
B 2 266 SER 266 267 267 SER SER B . n 
B 2 267 VAL 267 268 268 VAL VAL B . n 
B 2 268 PRO 268 269 269 PRO PRO B . n 
B 2 269 PHE 269 270 270 PHE PHE B . n 
B 2 270 LEU 270 271 271 LEU LEU B . n 
B 2 271 ALA 271 272 272 ALA ALA B . n 
B 2 272 SER 272 273 273 SER SER B . n 
B 2 273 LEU 273 274 274 LEU LEU B . n 
B 2 274 SER 274 275 275 SER SER B . n 
B 2 275 GLU 275 276 276 GLU GLU B . n 
B 2 276 ASP 276 277 277 ASP ASP B . n 
B 2 277 CYS 277 278 278 CYS CYS B . n 
B 2 278 SER 278 279 279 SER SER B . n 
B 2 279 LEU 279 280 280 LEU LEU B . n 
B 2 280 ALA 280 281 281 ALA ALA B . n 
B 2 281 VAL 281 282 282 VAL VAL B . n 
B 2 282 LEU 282 283 283 LEU LEU B . n 
B 2 283 ASP 283 284 284 ASP ASP B . n 
B 2 284 SER 284 285 285 SER SER B . n 
B 2 285 SER 285 286 286 SER SER B . n 
B 2 286 LEU 286 287 287 LEU LEU B . n 
B 2 287 SER 287 288 288 SER SER B . n 
B 2 288 GLU 288 289 289 GLU GLU B . n 
B 2 289 LEU 289 290 290 LEU LEU B . n 
B 2 290 PHE 290 291 291 PHE PHE B . n 
B 2 291 ARG 291 292 292 ARG ARG B . n 
B 2 292 SER 292 293 293 SER SER B . n 
B 2 293 GLN 293 294 294 GLN GLN B . n 
B 2 294 ALA 294 295 295 ALA ALA B . n 
B 2 295 HIS 295 296 296 HIS HIS B . n 
B 2 296 ARG 296 297 297 ARG ARG B . n 
B 2 297 ASP 297 298 298 ASP ASP B . n 
B 2 298 PHE 298 299 299 PHE PHE B . n 
B 2 299 VAL 299 300 300 VAL VAL B . n 
B 2 300 ARG 300 301 301 ARG ARG B . n 
B 2 301 ASP 301 302 302 ASP ASP B . n 
B 2 302 ALA 302 303 303 ALA ALA B . n 
B 2 303 THR 303 304 304 THR THR B . n 
B 2 304 TRP 304 305 305 TRP TRP B . n 
B 2 305 SER 305 306 306 SER SER B . n 
B 2 306 PRO 306 307 307 PRO PRO B . n 
B 2 307 LEU 307 308 308 LEU LEU B . n 
B 2 308 ASN 308 309 309 ASN ASN B . n 
B 2 309 HIS 309 310 310 HIS HIS B . n 
B 2 310 SER 310 311 311 SER SER B . n 
B 2 311 LEU 311 312 312 LEU LEU B . n 
B 2 312 LEU 312 313 313 LEU LEU B . n 
B 2 313 THR 313 314 314 THR THR B . n 
B 2 314 THR 314 315 315 THR THR B . n 
B 2 315 VAL 315 316 316 VAL VAL B . n 
B 2 316 GLY 316 317 317 GLY GLY B . n 
B 2 317 TRP 317 318 318 TRP TRP B . n 
B 2 318 ASP 318 319 319 ASP ASP B . n 
B 2 319 HIS 319 320 320 HIS HIS B . n 
B 2 320 GLN 320 321 321 GLN GLN B . n 
B 2 321 VAL 321 322 322 VAL VAL B . n 
B 2 322 VAL 322 323 323 VAL VAL B . n 
B 2 323 HIS 323 324 324 HIS HIS B . n 
B 2 324 HIS 324 325 325 HIS HIS B . n 
B 2 325 VAL 325 326 326 VAL VAL B . n 
B 2 326 VAL 326 327 327 VAL VAL B . n 
B 2 327 PRO 327 328 328 PRO PRO B . n 
B 2 328 THR 328 329 329 THR THR B . n 
B 2 329 GLU 329 330 ?   ?   ?   B . n 
B 2 330 PRO 330 331 ?   ?   ?   B . n 
B 2 331 LEU 331 332 ?   ?   ?   B . n 
B 2 332 PRO 332 333 ?   ?   ?   B . n 
B 2 333 ALA 333 334 ?   ?   ?   B . n 
B 2 334 PRO 334 335 ?   ?   ?   B . n 
B 2 335 GLY 335 336 ?   ?   ?   B . n 
B 2 336 PRO 336 337 ?   ?   ?   B . n 
B 2 337 ALA 337 338 ?   ?   ?   B . n 
B 2 338 SER 338 339 ?   ?   ?   B . n 
B 2 339 VAL 339 340 ?   ?   ?   B . n 
B 2 340 THR 340 341 ?   ?   ?   B . n 
B 2 341 GLU 341 342 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 A1A79 ? ? A1A79 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 EDO   ? ? EDO   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1A79 1   701  1   A1A79 LIG A . 
D 4 EDO   1   702  1   EDO   EDO A . 
E 4 EDO   1   703  2   EDO   EDO A . 
F 4 EDO   1   704  3   EDO   EDO A . 
G 4 EDO   1   705  4   EDO   EDO A . 
H 5 HOH   1   801  249 HOH   HOH A . 
H 5 HOH   2   802  146 HOH   HOH A . 
H 5 HOH   3   803  87  HOH   HOH A . 
H 5 HOH   4   804  11  HOH   HOH A . 
H 5 HOH   5   805  176 HOH   HOH A . 
H 5 HOH   6   806  179 HOH   HOH A . 
H 5 HOH   7   807  193 HOH   HOH A . 
H 5 HOH   8   808  5   HOH   HOH A . 
H 5 HOH   9   809  224 HOH   HOH A . 
H 5 HOH   10  810  171 HOH   HOH A . 
H 5 HOH   11  811  153 HOH   HOH A . 
H 5 HOH   12  812  248 HOH   HOH A . 
H 5 HOH   13  813  122 HOH   HOH A . 
H 5 HOH   14  814  81  HOH   HOH A . 
H 5 HOH   15  815  181 HOH   HOH A . 
H 5 HOH   16  816  141 HOH   HOH A . 
H 5 HOH   17  817  22  HOH   HOH A . 
H 5 HOH   18  818  32  HOH   HOH A . 
H 5 HOH   19  819  100 HOH   HOH A . 
H 5 HOH   20  820  199 HOH   HOH A . 
H 5 HOH   21  821  86  HOH   HOH A . 
H 5 HOH   22  822  53  HOH   HOH A . 
H 5 HOH   23  823  89  HOH   HOH A . 
H 5 HOH   24  824  257 HOH   HOH A . 
H 5 HOH   25  825  253 HOH   HOH A . 
H 5 HOH   26  826  61  HOH   HOH A . 
H 5 HOH   27  827  202 HOH   HOH A . 
H 5 HOH   28  828  188 HOH   HOH A . 
H 5 HOH   29  829  76  HOH   HOH A . 
H 5 HOH   30  830  19  HOH   HOH A . 
H 5 HOH   31  831  68  HOH   HOH A . 
H 5 HOH   32  832  266 HOH   HOH A . 
H 5 HOH   33  833  4   HOH   HOH A . 
H 5 HOH   34  834  125 HOH   HOH A . 
H 5 HOH   35  835  174 HOH   HOH A . 
H 5 HOH   36  836  216 HOH   HOH A . 
H 5 HOH   37  837  158 HOH   HOH A . 
H 5 HOH   38  838  82  HOH   HOH A . 
H 5 HOH   39  839  109 HOH   HOH A . 
H 5 HOH   40  840  180 HOH   HOH A . 
H 5 HOH   41  841  169 HOH   HOH A . 
H 5 HOH   42  842  243 HOH   HOH A . 
H 5 HOH   43  843  159 HOH   HOH A . 
H 5 HOH   44  844  148 HOH   HOH A . 
H 5 HOH   45  845  247 HOH   HOH A . 
H 5 HOH   46  846  117 HOH   HOH A . 
H 5 HOH   47  847  208 HOH   HOH A . 
H 5 HOH   48  848  17  HOH   HOH A . 
H 5 HOH   49  849  115 HOH   HOH A . 
H 5 HOH   50  850  242 HOH   HOH A . 
H 5 HOH   51  851  124 HOH   HOH A . 
H 5 HOH   52  852  45  HOH   HOH A . 
H 5 HOH   53  853  74  HOH   HOH A . 
H 5 HOH   54  854  162 HOH   HOH A . 
H 5 HOH   55  855  120 HOH   HOH A . 
H 5 HOH   56  856  130 HOH   HOH A . 
H 5 HOH   57  857  72  HOH   HOH A . 
H 5 HOH   58  858  102 HOH   HOH A . 
H 5 HOH   59  859  92  HOH   HOH A . 
H 5 HOH   60  860  155 HOH   HOH A . 
H 5 HOH   61  861  172 HOH   HOH A . 
H 5 HOH   62  862  10  HOH   HOH A . 
H 5 HOH   63  863  219 HOH   HOH A . 
H 5 HOH   64  864  229 HOH   HOH A . 
H 5 HOH   65  865  213 HOH   HOH A . 
H 5 HOH   66  866  211 HOH   HOH A . 
H 5 HOH   67  867  175 HOH   HOH A . 
H 5 HOH   68  868  238 HOH   HOH A . 
H 5 HOH   69  869  111 HOH   HOH A . 
H 5 HOH   70  870  151 HOH   HOH A . 
H 5 HOH   71  871  123 HOH   HOH A . 
H 5 HOH   72  872  160 HOH   HOH A . 
H 5 HOH   73  873  37  HOH   HOH A . 
H 5 HOH   74  874  170 HOH   HOH A . 
H 5 HOH   75  875  2   HOH   HOH A . 
H 5 HOH   76  876  73  HOH   HOH A . 
H 5 HOH   77  877  255 HOH   HOH A . 
H 5 HOH   78  878  129 HOH   HOH A . 
H 5 HOH   79  879  142 HOH   HOH A . 
H 5 HOH   80  880  195 HOH   HOH A . 
H 5 HOH   81  881  12  HOH   HOH A . 
H 5 HOH   82  882  187 HOH   HOH A . 
H 5 HOH   83  883  191 HOH   HOH A . 
H 5 HOH   84  884  232 HOH   HOH A . 
H 5 HOH   85  885  149 HOH   HOH A . 
H 5 HOH   86  886  200 HOH   HOH A . 
H 5 HOH   87  887  93  HOH   HOH A . 
H 5 HOH   88  888  140 HOH   HOH A . 
H 5 HOH   89  889  112 HOH   HOH A . 
H 5 HOH   90  890  186 HOH   HOH A . 
H 5 HOH   91  891  42  HOH   HOH A . 
H 5 HOH   92  892  221 HOH   HOH A . 
H 5 HOH   93  893  157 HOH   HOH A . 
H 5 HOH   94  894  190 HOH   HOH A . 
H 5 HOH   95  895  137 HOH   HOH A . 
H 5 HOH   96  896  150 HOH   HOH A . 
H 5 HOH   97  897  164 HOH   HOH A . 
H 5 HOH   98  898  49  HOH   HOH A . 
H 5 HOH   99  899  210 HOH   HOH A . 
H 5 HOH   100 900  51  HOH   HOH A . 
H 5 HOH   101 901  133 HOH   HOH A . 
H 5 HOH   102 902  241 HOH   HOH A . 
H 5 HOH   103 903  178 HOH   HOH A . 
H 5 HOH   104 904  39  HOH   HOH A . 
H 5 HOH   105 905  156 HOH   HOH A . 
H 5 HOH   106 906  173 HOH   HOH A . 
H 5 HOH   107 907  214 HOH   HOH A . 
H 5 HOH   108 908  34  HOH   HOH A . 
H 5 HOH   109 909  64  HOH   HOH A . 
H 5 HOH   110 910  71  HOH   HOH A . 
H 5 HOH   111 911  184 HOH   HOH A . 
H 5 HOH   112 912  196 HOH   HOH A . 
H 5 HOH   113 913  177 HOH   HOH A . 
H 5 HOH   114 914  228 HOH   HOH A . 
H 5 HOH   115 915  183 HOH   HOH A . 
H 5 HOH   116 916  240 HOH   HOH A . 
H 5 HOH   117 917  144 HOH   HOH A . 
H 5 HOH   118 918  106 HOH   HOH A . 
H 5 HOH   119 919  222 HOH   HOH A . 
H 5 HOH   120 920  9   HOH   HOH A . 
H 5 HOH   121 921  259 HOH   HOH A . 
H 5 HOH   122 922  152 HOH   HOH A . 
H 5 HOH   123 923  26  HOH   HOH A . 
H 5 HOH   124 924  147 HOH   HOH A . 
H 5 HOH   125 925  182 HOH   HOH A . 
H 5 HOH   126 926  94  HOH   HOH A . 
H 5 HOH   127 927  239 HOH   HOH A . 
H 5 HOH   128 928  70  HOH   HOH A . 
H 5 HOH   129 929  168 HOH   HOH A . 
H 5 HOH   130 930  244 HOH   HOH A . 
H 5 HOH   131 931  35  HOH   HOH A . 
H 5 HOH   132 932  30  HOH   HOH A . 
H 5 HOH   133 933  143 HOH   HOH A . 
H 5 HOH   134 934  166 HOH   HOH A . 
H 5 HOH   135 935  121 HOH   HOH A . 
H 5 HOH   136 936  110 HOH   HOH A . 
H 5 HOH   137 937  163 HOH   HOH A . 
H 5 HOH   138 938  25  HOH   HOH A . 
H 5 HOH   139 939  194 HOH   HOH A . 
H 5 HOH   140 940  95  HOH   HOH A . 
H 5 HOH   141 941  63  HOH   HOH A . 
H 5 HOH   142 942  161 HOH   HOH A . 
H 5 HOH   143 943  21  HOH   HOH A . 
H 5 HOH   144 944  91  HOH   HOH A . 
H 5 HOH   145 945  50  HOH   HOH A . 
H 5 HOH   146 946  139 HOH   HOH A . 
H 5 HOH   147 947  189 HOH   HOH A . 
H 5 HOH   148 948  261 HOH   HOH A . 
H 5 HOH   149 949  15  HOH   HOH A . 
H 5 HOH   150 950  38  HOH   HOH A . 
H 5 HOH   151 951  79  HOH   HOH A . 
H 5 HOH   152 952  118 HOH   HOH A . 
H 5 HOH   153 953  60  HOH   HOH A . 
H 5 HOH   154 954  234 HOH   HOH A . 
H 5 HOH   155 955  31  HOH   HOH A . 
H 5 HOH   156 956  59  HOH   HOH A . 
H 5 HOH   157 957  52  HOH   HOH A . 
H 5 HOH   158 958  80  HOH   HOH A . 
H 5 HOH   159 959  58  HOH   HOH A . 
H 5 HOH   160 960  132 HOH   HOH A . 
H 5 HOH   161 961  107 HOH   HOH A . 
H 5 HOH   162 962  258 HOH   HOH A . 
H 5 HOH   163 963  101 HOH   HOH A . 
H 5 HOH   164 964  16  HOH   HOH A . 
H 5 HOH   165 965  67  HOH   HOH A . 
H 5 HOH   166 966  48  HOH   HOH A . 
H 5 HOH   167 967  66  HOH   HOH A . 
H 5 HOH   168 968  65  HOH   HOH A . 
H 5 HOH   169 969  40  HOH   HOH A . 
H 5 HOH   170 970  206 HOH   HOH A . 
H 5 HOH   171 971  77  HOH   HOH A . 
H 5 HOH   172 972  246 HOH   HOH A . 
H 5 HOH   173 973  54  HOH   HOH A . 
H 5 HOH   174 974  105 HOH   HOH A . 
H 5 HOH   175 975  103 HOH   HOH A . 
H 5 HOH   176 976  43  HOH   HOH A . 
H 5 HOH   177 977  88  HOH   HOH A . 
H 5 HOH   178 978  262 HOH   HOH A . 
H 5 HOH   179 979  217 HOH   HOH A . 
H 5 HOH   180 980  47  HOH   HOH A . 
H 5 HOH   181 981  212 HOH   HOH A . 
H 5 HOH   182 982  104 HOH   HOH A . 
H 5 HOH   183 983  245 HOH   HOH A . 
H 5 HOH   184 984  231 HOH   HOH A . 
H 5 HOH   185 985  33  HOH   HOH A . 
H 5 HOH   186 986  41  HOH   HOH A . 
H 5 HOH   187 987  36  HOH   HOH A . 
H 5 HOH   188 988  131 HOH   HOH A . 
H 5 HOH   189 989  256 HOH   HOH A . 
H 5 HOH   190 990  134 HOH   HOH A . 
H 5 HOH   191 991  90  HOH   HOH A . 
H 5 HOH   192 992  99  HOH   HOH A . 
H 5 HOH   193 993  24  HOH   HOH A . 
H 5 HOH   194 994  250 HOH   HOH A . 
H 5 HOH   195 995  230 HOH   HOH A . 
H 5 HOH   196 996  135 HOH   HOH A . 
H 5 HOH   197 997  3   HOH   HOH A . 
H 5 HOH   198 998  18  HOH   HOH A . 
H 5 HOH   199 999  13  HOH   HOH A . 
H 5 HOH   200 1000 1   HOH   HOH A . 
H 5 HOH   201 1001 23  HOH   HOH A . 
H 5 HOH   202 1002 215 HOH   HOH A . 
H 5 HOH   203 1003 14  HOH   HOH A . 
H 5 HOH   204 1004 235 HOH   HOH A . 
H 5 HOH   205 1005 119 HOH   HOH A . 
H 5 HOH   206 1006 237 HOH   HOH A . 
H 5 HOH   207 1007 75  HOH   HOH A . 
H 5 HOH   208 1008 113 HOH   HOH A . 
H 5 HOH   209 1009 69  HOH   HOH A . 
H 5 HOH   210 1010 20  HOH   HOH A . 
H 5 HOH   211 1011 78  HOH   HOH A . 
I 5 HOH   1   401  85  HOH   HOH B . 
I 5 HOH   2   402  254 HOH   HOH B . 
I 5 HOH   3   403  57  HOH   HOH B . 
I 5 HOH   4   404  227 HOH   HOH B . 
I 5 HOH   5   405  197 HOH   HOH B . 
I 5 HOH   6   406  145 HOH   HOH B . 
I 5 HOH   7   407  192 HOH   HOH B . 
I 5 HOH   8   408  98  HOH   HOH B . 
I 5 HOH   9   409  185 HOH   HOH B . 
I 5 HOH   10  410  97  HOH   HOH B . 
I 5 HOH   11  411  203 HOH   HOH B . 
I 5 HOH   12  412  198 HOH   HOH B . 
I 5 HOH   13  413  27  HOH   HOH B . 
I 5 HOH   14  414  56  HOH   HOH B . 
I 5 HOH   15  415  128 HOH   HOH B . 
I 5 HOH   16  416  154 HOH   HOH B . 
I 5 HOH   17  417  201 HOH   HOH B . 
I 5 HOH   18  418  6   HOH   HOH B . 
I 5 HOH   19  419  205 HOH   HOH B . 
I 5 HOH   20  420  223 HOH   HOH B . 
I 5 HOH   21  421  209 HOH   HOH B . 
I 5 HOH   22  422  165 HOH   HOH B . 
I 5 HOH   23  423  207 HOH   HOH B . 
I 5 HOH   24  424  225 HOH   HOH B . 
I 5 HOH   25  425  44  HOH   HOH B . 
I 5 HOH   26  426  204 HOH   HOH B . 
I 5 HOH   27  427  167 HOH   HOH B . 
I 5 HOH   28  428  260 HOH   HOH B . 
I 5 HOH   29  429  218 HOH   HOH B . 
I 5 HOH   30  430  220 HOH   HOH B . 
I 5 HOH   31  431  116 HOH   HOH B . 
I 5 HOH   32  432  8   HOH   HOH B . 
I 5 HOH   33  433  252 HOH   HOH B . 
I 5 HOH   34  434  108 HOH   HOH B . 
I 5 HOH   35  435  46  HOH   HOH B . 
I 5 HOH   36  436  55  HOH   HOH B . 
I 5 HOH   37  437  265 HOH   HOH B . 
I 5 HOH   38  438  136 HOH   HOH B . 
I 5 HOH   39  439  62  HOH   HOH B . 
I 5 HOH   40  440  126 HOH   HOH B . 
I 5 HOH   41  441  233 HOH   HOH B . 
I 5 HOH   42  442  28  HOH   HOH B . 
I 5 HOH   43  443  83  HOH   HOH B . 
I 5 HOH   44  444  251 HOH   HOH B . 
I 5 HOH   45  445  264 HOH   HOH B . 
I 5 HOH   46  446  127 HOH   HOH B . 
I 5 HOH   47  447  29  HOH   HOH B . 
I 5 HOH   48  448  114 HOH   HOH B . 
I 5 HOH   49  449  96  HOH   HOH B . 
I 5 HOH   50  450  7   HOH   HOH B . 
I 5 HOH   51  451  84  HOH   HOH B . 
I 5 HOH   52  452  226 HOH   HOH B . 
I 5 HOH   53  453  236 HOH   HOH B . 
I 5 HOH   54  454  263 HOH   HOH B . 
I 5 HOH   55  455  138 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.8.0267 1 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.28     2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? DIALS       ? ? ? .        3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .        4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .        5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DOD 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     102.567 
_cell.length_a_esd                 ? 
_cell.length_b                     139.202 
_cell.length_b_esd                 ? 
_cell.length_c                     178.548 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DOD 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DOD 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.92 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Na-Cit,0.2M NaAc,11% PEG4000,pH6.0' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97627 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97627 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9DOD 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.50 
_reflns.d_resolution_low                               54.95 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     44312 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                14.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          25.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.062 
_reflns.pdbx_Rpim_I_all                                0.017 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.984 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.060 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.50 
_reflns_shell.d_res_low                                     2.59 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4599 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.622 
_reflns_shell.pdbx_Rpim_I_all                               0.162 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.982 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.4 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.600 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            8.6700 
_refine.aniso_B[1][2]                            -0.0000 
_refine.aniso_B[1][3]                            0.0000 
_refine.aniso_B[2][2]                            -0.8500 
_refine.aniso_B[2][3]                            0.0000 
_refine.aniso_B[3][3]                            -7.8300 
_refine.B_iso_max                                213.430 
_refine.B_iso_mean                               73.5640 
_refine.B_iso_min                                42.530 
_refine.correlation_coeff_Fo_to_Fc               0.9550 
_refine.correlation_coeff_Fo_to_Fc_free          0.9240 
_refine.details                                  
'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : REFINED INDIVIDUALLY' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DOD 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.5000 
_refine.ls_d_res_low                             54.9500 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42104 
_refine.ls_number_reflns_R_free                  2205 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.4700 
_refine.ls_percent_reflns_R_free                 5.0000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2072 
_refine.ls_R_factor_R_free                       0.2587 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2046 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.4330 
_refine.pdbx_overall_ESU_R_Free                  0.2820 
_refine.pdbx_solvent_vdw_probe_radii             1.2000 
_refine.pdbx_solvent_ion_probe_radii             0.8000 
_refine.pdbx_solvent_shrinkage_radii             0.8000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             13.0760 
_refine.overall_SU_ML                            0.2640 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.5000 
_refine_hist.d_res_low                        54.9500 
_refine_hist.number_atoms_solvent             266 
_refine_hist.number_atoms_total               7731 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       938 
_refine_hist.pdbx_B_iso_mean_ligand           58.90 
_refine_hist.pdbx_B_iso_mean_solvent          62.50 
_refine_hist.pdbx_number_atoms_protein        7421 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         44 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003  0.013  7663  ? r_bond_refined_d       ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.015  7058  ? r_bond_other_d         ? ? 
'X-RAY DIFFRACTION' ? 1.251  1.644  10440 ? r_angle_refined_deg    ? ? 
'X-RAY DIFFRACTION' ? 1.094  1.575  16285 ? r_angle_other_deg      ? ? 
'X-RAY DIFFRACTION' ? 7.384  5.000  936   ? r_dihedral_angle_1_deg ? ? 
'X-RAY DIFFRACTION' ? 31.394 22.325 400   ? r_dihedral_angle_2_deg ? ? 
'X-RAY DIFFRACTION' ? 14.245 15.000 1230  ? r_dihedral_angle_3_deg ? ? 
'X-RAY DIFFRACTION' ? 14.255 15.000 47    ? r_dihedral_angle_4_deg ? ? 
'X-RAY DIFFRACTION' ? 0.045  0.200  983   ? r_chiral_restr         ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.020  8681  ? r_gen_planes_refined   ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1777  ? r_gen_planes_other     ? ? 
'X-RAY DIFFRACTION' ? 3.125  7.832  3750  ? r_mcbond_it            ? ? 
'X-RAY DIFFRACTION' ? 3.122  7.831  3749  ? r_mcbond_other         ? ? 
'X-RAY DIFFRACTION' ? 5.221  11.739 4684  ? r_mcangle_it           ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.5000 
_refine_ls_shell.d_res_low                        2.5650 
_refine_ls_shell.number_reflns_all                3211 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             154 
_refine_ls_shell.number_reflns_R_work             3057 
_refine_ls_shell.percent_reflns_obs               99.0100 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            0.0000 
_refine_ls_shell.R_factor_R_work                  0.3570 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.3280 
# 
_struct.entry_id                     9DOD 
_struct.title                        'Crystal structure of PRMT5:MEP50 in complex with PRT543' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DOD 
_struct_keywords.text            'PRMT5, MEP50, inhibitor, protein-ligand complex, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ANM5_HUMAN  O14744 ? 1 
;AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTL
IVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPE
DLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKK
GFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLES
QTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTL
ENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLY
NEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQ
DITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
;
2 
2 UNP MEP50_HUMAN Q9BQA1 ? 2 
;RKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEA
GVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLS
SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD
TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ
VVHHVVPTEPLPAPGPASVTE
;
2 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DOD A 1 ? 636 ? O14744 2 ? 637 ? 2 637 
2 2 9DOD B 1 ? 341 ? Q9BQA1 2 ? 342 ? 2 342 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5770  ? 
1 MORE         -5    ? 
1 'SSA (A^2)'  38070 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 24  ? GLY A 36  ? GLU A 25  GLY A 37  1 ? 13 
HELX_P HELX_P2  AA2 PRO A 57  ? ARG A 61  ? PRO A 58  ARG A 62  5 ? 5  
HELX_P HELX_P3  AA3 SER A 68  ? LEU A 72  ? SER A 69  LEU A 73  5 ? 5  
HELX_P HELX_P4  AA4 SER A 73  ? LEU A 80  ? SER A 74  LEU A 81  1 ? 8  
HELX_P HELX_P5  AA5 VAL A 95  ? GLY A 117 ? VAL A 96  GLY A 118 1 ? 23 
HELX_P HELX_P6  AA6 ASN A 130 ? HIS A 142 ? ASN A 131 HIS A 143 1 ? 13 
HELX_P HELX_P7  AA7 ALA A 158 ? LEU A 162 ? ALA A 159 LEU A 163 5 ? 5  
HELX_P HELX_P8  AA8 SER A 179 ? GLU A 181 ? SER A 180 GLU A 182 5 ? 3  
HELX_P HELX_P9  AA9 GLU A 182 ? CYS A 195 ? GLU A 183 CYS A 196 1 ? 14 
HELX_P HELX_P10 AB1 SER A 213 ? ARG A 219 ? SER A 214 ARG A 220 1 ? 7  
HELX_P HELX_P11 AB2 SER A 233 ? PHE A 235 ? SER A 234 PHE A 236 5 ? 3  
HELX_P HELX_P12 AB3 SER A 246 ? LEU A 259 ? SER A 247 LEU A 260 1 ? 14 
HELX_P HELX_P13 AB4 PHE A 276 ? ASN A 289 ? PHE A 277 ASN A 290 1 ? 14 
HELX_P HELX_P14 AB5 ASN A 294 ? PHE A 299 ? ASN A 295 PHE A 300 1 ? 6  
HELX_P HELX_P15 AB6 GLU A 319 ? LYS A 328 ? GLU A 320 LYS A 329 1 ? 10 
HELX_P HELX_P16 AB7 ASP A 329 ? VAL A 348 ? ASP A 330 VAL A 349 1 ? 20 
HELX_P HELX_P17 AB8 PRO A 349 ? LYS A 353 ? PRO A 350 LYS A 354 5 ? 5  
HELX_P HELX_P18 AB9 GLY A 368 ? ASP A 382 ? GLY A 369 ASP A 383 1 ? 15 
HELX_P HELX_P19 AC1 ASN A 393 ? GLU A 407 ? ASN A 394 GLU A 408 1 ? 15 
HELX_P HELX_P20 AC2 TRP A 408 ? SER A 410 ? TRP A 409 SER A 411 5 ? 3  
HELX_P HELX_P21 AC3 ALA A 440 ? GLU A 443 ? ALA A 441 GLU A 444 5 ? 4  
HELX_P HELX_P22 AC4 LEU A 444 ? GLN A 453 ? LEU A 445 GLN A 454 1 ? 10 
HELX_P HELX_P23 AC5 SER A 476 ? ALA A 485 ? SER A 477 ALA A 486 1 ? 10 
HELX_P HELX_P24 AC6 GLU A 494 ? GLU A 498 ? GLU A 495 GLU A 499 5 ? 5  
HELX_P HELX_P25 AC7 ARG A 567 ? HIS A 571 ? ARG A 568 HIS A 572 5 ? 5  
HELX_P HELX_P26 AC8 ASN A 626 ? ARG A 630 ? ASN A 627 ARG A 631 5 ? 5  
HELX_P HELX_P27 AC9 ASP B 62  ? ALA B 66  ? ASP B 63  ALA B 67  5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 56  A . ? GLU 57  A PRO 57  A ? PRO 58  A 1 3.31  
2 ILE 463 A . ? ILE 464 A PRO 464 A ? PRO 465 A 1 12.62 
3 HIS 522 A . ? HIS 523 A PRO 523 A ? PRO 524 A 1 -1.33 
4 ALA 618 A . ? ALA 619 A PRO 619 A ? PRO 620 A 1 1.01  
5 ALA 66  B . ? ALA 67  B PRO 67  B ? PRO 68  B 1 10.34 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 9 ? 
AA2 ? 2 ? 
AA3 ? 5 ? 
AA4 ? 5 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 4 ? 
AB4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA1 8 9 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 15  ? ASP A 18  ? SER A 16  ASP A 19  
AA1 2 PHE A 39  ? PRO A 43  ? PHE A 40  PRO A 44  
AA1 3 ILE A 81  ? LYS A 84  ? ILE A 82  LYS A 85  
AA1 4 ALA A 120 ? PRO A 124 ? ALA A 121 PRO A 125 
AA1 5 MET A 149 ? PRO A 155 ? MET A 150 PRO A 156 
AA1 6 ILE A 201 ? GLU A 206 ? ILE A 202 GLU A 207 
AA1 7 ILE A 225 ? PRO A 231 ? ILE A 226 PRO A 232 
AA1 8 GLN A 262 ? THR A 266 ? GLN A 263 THR A 267 
AA1 9 SER A 15  ? ASP A 18  ? SER A 16  ASP A 19  
AA2 1 LEU A 236 ? THR A 237 ? LEU A 237 THR A 238 
AA2 2 PRO A 243 ? VAL A 244 ? PRO A 244 VAL A 245 
AA3 1 VAL A 412 ? SER A 416 ? VAL A 413 SER A 417 
AA3 2 ARG A 384 ? GLU A 391 ? ARG A 385 GLU A 392 
AA3 3 VAL A 357 ? LEU A 363 ? VAL A 358 LEU A 364 
AA3 4 ALA A 428 ? SER A 433 ? ALA A 429 SER A 434 
AA3 5 LEU A 456 ? ILE A 463 ? LEU A 457 ILE A 464 
AA4 1 TYR A 501 ? VAL A 502 ? TYR A 502 VAL A 503 
AA4 2 ILE A 581 ? VAL A 591 ? ILE A 582 VAL A 592 
AA4 3 THR A 545 ? TYR A 559 ? THR A 546 TYR A 560 
AA4 4 GLU A 466 ? SER A 475 ? GLU A 467 SER A 476 
AA4 5 GLN A 515 ? SER A 521 ? GLN A 516 SER A 522 
AA5 1 HIS A 509 ? GLN A 510 ? HIS A 510 GLN A 511 
AA5 2 GLU A 466 ? SER A 475 ? GLU A 467 SER A 476 
AA5 3 THR A 545 ? TYR A 559 ? THR A 546 TYR A 560 
AA5 4 ILE A 562 ? SER A 565 ? ILE A 563 SER A 566 
AA6 1 ARG A 533 ? PRO A 540 ? ARG A 534 PRO A 541 
AA6 2 THR A 596 ? SER A 605 ? THR A 597 SER A 606 
AA6 3 LYS A 609 ? ALA A 618 ? LYS A 610 ALA A 619 
AA6 4 ILE A 634 ? GLY A 635 ? ILE A 635 GLY A 636 
AA7 1 GLN B 29  ? TYR B 35  ? GLN B 30  TYR B 36  
AA7 2 LEU B 41  ? SER B 46  ? LEU B 42  SER B 47  
AA7 3 GLY B 55  ? PHE B 60  ? GLY B 56  PHE B 61  
AA7 4 ALA B 74  ? THR B 78  ? ALA B 75  THR B 79  
AA8 1 VAL B 82  ? VAL B 88  ? VAL B 83  VAL B 89  
AA8 2 GLY B 92  ? SER B 97  ? GLY B 93  SER B 98  
AA8 3 ALA B 101 ? LEU B 107 ? ALA B 102 LEU B 108 
AA8 4 ILE B 114 ? TYR B 121 ? ILE B 115 TYR B 122 
AA9 1 VAL B 127 ? VAL B 132 ? VAL B 128 VAL B 133 
AA9 2 GLN B 138 ? SER B 143 ? GLN B 139 SER B 144 
AA9 3 ILE B 148 ? ASP B 152 ? ILE B 149 ASP B 153 
AA9 4 VAL B 157 ? TYR B 162 ? VAL B 158 TYR B 163 
AB1 1 VAL B 169 ? ALA B 174 ? VAL B 170 ALA B 175 
AB1 2 VAL B 181 ? SER B 186 ? VAL B 182 SER B 187 
AB1 3 ILE B 191 ? ASP B 195 ? ILE B 192 ASP B 196 
AB1 4 ALA B 202 ? ILE B 205 ? ALA B 203 ILE B 206 
AB2 1 PRO B 214 ? TRP B 219 ? PRO B 215 TRP B 220 
AB2 2 VAL B 226 ? ASP B 231 ? VAL B 227 ASP B 232 
AB2 3 THR B 235 ? ASP B 240 ? THR B 236 ASP B 241 
AB2 4 VAL B 247 ? ALA B 251 ? VAL B 248 ALA B 252 
AB3 1 LEU B 260 ? PHE B 262 ? LEU B 261 PHE B 263 
AB3 2 LEU B 270 ? LEU B 273 ? LEU B 271 LEU B 274 
AB3 3 LEU B 279 ? LEU B 282 ? LEU B 280 LEU B 283 
AB3 4 GLU B 288 ? SER B 292 ? GLU B 289 SER B 293 
AB4 1 VAL B 299 ? TRP B 304 ? VAL B 300 TRP B 305 
AB4 2 LEU B 311 ? GLY B 316 ? LEU B 312 GLY B 317 
AB4 3 VAL B 321 ? VAL B 325 ? VAL B 322 VAL B 326 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 17  ? N ARG A 18  O CYS A 41  ? O CYS A 42  
AA1 2 3 N LEU A 40  ? N LEU A 41  O VAL A 82  ? O VAL A 83  
AA1 3 4 N GLY A 83  ? N GLY A 84  O LEU A 122 ? O LEU A 123 
AA1 4 5 N LEU A 123 ? N LEU A 124 O ARG A 153 ? O ARG A 154 
AA1 5 6 N PHE A 150 ? N PHE A 151 O ALA A 202 ? O ALA A 203 
AA1 6 7 N LEU A 205 ? N LEU A 206 O ALA A 227 ? O ALA A 228 
AA1 7 8 N LEU A 230 ? N LEU A 231 O ILE A 264 ? O ILE A 265 
AA1 8 9 O ILE A 265 ? O ILE A 266 N ASP A 18  ? N ASP A 19  
AA2 1 2 N LEU A 236 ? N LEU A 237 O VAL A 244 ? O VAL A 245 
AA3 1 2 O VAL A 415 ? O VAL A 416 N ALA A 389 ? N ALA A 390 
AA3 2 3 O TYR A 388 ? O TYR A 389 N VAL A 362 ? N VAL A 363 
AA3 3 4 N MET A 361 ? N MET A 362 O VAL A 432 ? O VAL A 433 
AA3 4 5 N ALA A 428 ? N ALA A 429 O LYS A 457 ? O LYS A 458 
AA4 1 2 N TYR A 501 ? N TYR A 502 O LEU A 582 ? O LEU A 583 
AA4 2 3 O PHE A 583 ? O PHE A 584 N PHE A 550 ? N PHE A 551 
AA4 3 4 O GLU A 555 ? O GLU A 556 N THR A 468 ? N THR A 469 
AA4 4 5 N SER A 469 ? N SER A 470 O CYS A 517 ? O CYS A 518 
AA5 1 2 O HIS A 509 ? O HIS A 510 N SER A 475 ? N SER A 476 
AA5 2 3 N THR A 468 ? N THR A 469 O GLU A 555 ? O GLU A 556 
AA5 3 4 N TYR A 559 ? N TYR A 560 O ILE A 562 ? O ILE A 563 
AA6 1 2 N PHE A 539 ? N PHE A 540 O ILE A 597 ? O ILE A 598 
AA6 2 3 N TRP A 602 ? N TRP A 603 O GLU A 613 ? O GLU A 614 
AA6 3 4 N VAL A 610 ? N VAL A 611 O ILE A 634 ? O ILE A 635 
AA7 1 2 N ARG B 34  ? N ARG B 35  O LEU B 42  ? O LEU B 43  
AA7 2 3 N LEU B 43  ? N LEU B 44  O TRP B 58  ? O TRP B 59  
AA7 3 4 N LEU B 59  ? N LEU B 60  O ALA B 74  ? O ALA B 75  
AA8 1 2 N THR B 86  ? N THR B 87  O LEU B 94  ? O LEU B 95  
AA8 2 3 N ILE B 93  ? N ILE B 94  O TRP B 105 ? O TRP B 106 
AA8 3 4 N LEU B 104 ? N LEU B 105 O LYS B 117 ? O LYS B 118 
AA9 1 2 N THR B 129 ? N THR B 130 O GLY B 142 ? O GLY B 143 
AA9 2 3 N ALA B 139 ? N ALA B 140 O TRP B 151 ? O TRP B 152 
AA9 3 4 N ILE B 148 ? N ILE B 149 O TYR B 162 ? O TYR B 163 
AB1 1 2 N ALA B 173 ? N ALA B 174 O LEU B 183 ? O LEU B 184 
AB1 2 3 N PHE B 182 ? N PHE B 183 O TRP B 194 ? O TRP B 195 
AB1 3 4 N LEU B 193 ? N LEU B 194 O SER B 203 ? O SER B 204 
AB2 1 2 N THR B 215 ? N THR B 216 O GLY B 230 ? O GLY B 231 
AB2 2 3 N PHE B 227 ? N PHE B 228 O VAL B 239 ? O VAL B 240 
AB2 3 4 N LEU B 238 ? N LEU B 239 O LEU B 248 ? O LEU B 249 
AB3 1 2 N VAL B 261 ? N VAL B 262 O ALA B 271 ? O ALA B 272 
AB3 2 3 N LEU B 270 ? N LEU B 271 O LEU B 282 ? O LEU B 283 
AB3 3 4 N VAL B 281 ? N VAL B 282 O LEU B 289 ? O LEU B 290 
AB4 1 2 N THR B 303 ? N THR B 304 O THR B 313 ? O THR B 314 
AB4 2 3 N LEU B 312 ? N LEU B 313 O HIS B 324 ? O HIS B 325 
# 
_pdbx_entry_details.entry_id                   9DOD 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OG 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   SER 
_pdbx_validate_close_contact.auth_seq_id_1    47 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    401 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.15 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PRO A 63  ? ? -67.67  -171.23 
2  1 HIS A 146 ? ? -110.73 61.11   
3  1 ALA A 171 ? ? -154.86 72.25   
4  1 SER A 247 ? ? -48.89  155.24  
5  1 GLU A 261 ? ? 38.16   46.54   
6  1 ASP A 330 ? ? -159.58 75.92   
7  1 GLU A 408 ? ? -135.68 -67.55  
8  1 ALA A 441 ? ? 65.73   -78.99  
9  1 LEU A 445 ? ? 79.43   37.09   
10 1 SER A 477 ? ? -161.66 94.17   
11 1 HIS A 507 ? ? -119.44 -72.00  
12 1 CYS A 518 ? ? -112.90 -77.65  
13 1 ASP A 527 ? ? -30.10  124.89  
14 1 THR A 546 ? ? -176.62 -177.24 
15 1 GLN A 561 ? ? 50.80   -119.78 
16 1 ILE B 147 ? ? 84.97   -8.81   
17 1 ARG B 164 ? ? -101.26 75.48   
18 1 ASP B 196 ? ? -161.70 98.39   
19 1 SER B 225 ? ? -67.21  8.51    
20 1 THR B 245 ? ? 63.96   -124.61 
21 1 CYS B 257 ? ? -39.50  143.49  
22 1 LEU B 290 ? ? -97.29  -60.94  
23 1 SER B 293 ? ? -160.39 109.71  
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     1003 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   H 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1010 ? 5.91 . 
2 1 O ? A HOH 1011 ? 8.16 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ALA 2   ? A ALA 1   
2  1 Y 1 A ALA 3   ? A ALA 2   
3  1 Y 1 A MET 4   ? A MET 3   
4  1 Y 1 A ALA 5   ? A ALA 4   
5  1 Y 1 A VAL 6   ? A VAL 5   
6  1 Y 1 A GLY 7   ? A GLY 6   
7  1 Y 1 A GLY 8   ? A GLY 7   
8  1 Y 1 A ALA 9   ? A ALA 8   
9  1 Y 1 A GLY 10  ? A GLY 9   
10 1 Y 1 A GLY 11  ? A GLY 10  
11 1 Y 1 B ARG 2   ? B ARG 1   
12 1 Y 1 B LYS 3   ? B LYS 2   
13 1 Y 1 B GLU 4   ? B GLU 3   
14 1 Y 1 B THR 5   ? B THR 4   
15 1 Y 1 B PRO 6   ? B PRO 5   
16 1 Y 1 B PRO 7   ? B PRO 6   
17 1 Y 1 B PRO 8   ? B PRO 7   
18 1 Y 1 B LEU 9   ? B LEU 8   
19 1 Y 1 B VAL 10  ? B VAL 9   
20 1 Y 1 B PRO 11  ? B PRO 10  
21 1 Y 1 B PRO 12  ? B PRO 11  
22 1 Y 1 B ALA 13  ? B ALA 12  
23 1 Y 1 B ALA 14  ? B ALA 13  
24 1 Y 1 B ARG 15  ? B ARG 14  
25 1 Y 1 B GLU 16  ? B GLU 15  
26 1 Y 1 B TRP 17  ? B TRP 16  
27 1 Y 1 B GLU 330 ? B GLU 329 
28 1 Y 1 B PRO 331 ? B PRO 330 
29 1 Y 1 B LEU 332 ? B LEU 331 
30 1 Y 1 B PRO 333 ? B PRO 332 
31 1 Y 1 B ALA 334 ? B ALA 333 
32 1 Y 1 B PRO 335 ? B PRO 334 
33 1 Y 1 B GLY 336 ? B GLY 335 
34 1 Y 1 B PRO 337 ? B PRO 336 
35 1 Y 1 B ALA 338 ? B ALA 337 
36 1 Y 1 B SER 339 ? B SER 338 
37 1 Y 1 B VAL 340 ? B VAL 339 
38 1 Y 1 B THR 341 ? B THR 340 
39 1 Y 1 B GLU 342 ? B GLU 341 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1A79 N1   N  Y N 1   
A1A79 N3   N  Y N 2   
A1A79 C4   C  Y N 3   
A1A79 C5   C  Y N 4   
A1A79 C6   C  Y N 5   
A1A79 C7   C  N R 6   
A1A79 C8   C  N R 7   
A1A79 C10  C  N R 8   
A1A79 C13  C  Y N 9   
A1A79 C15  C  Y N 10  
A1A79 C17  C  Y N 11  
A1A79 C1   C  Y N 12  
A1A79 C2   C  Y N 13  
A1A79 C3   C  Y N 14  
A1A79 CL1  CL N N 15  
A1A79 CL2  CL N N 16  
A1A79 O1   O  N N 17  
A1A79 C9   C  N S 18  
A1A79 C11  C  N R 19  
A1A79 O2   O  N N 20  
A1A79 O3   O  N N 21  
A1A79 C12  C  Y N 22  
A1A79 C14  C  Y N 23  
A1A79 N2   N  Y N 24  
A1A79 C16  C  Y N 25  
A1A79 N4   N  N N 26  
A1A79 C18  C  N N 27  
A1A79 O4   O  N N 28  
A1A79 H1   H  N N 29  
A1A79 H2   H  N N 30  
A1A79 H3   H  N N 31  
A1A79 H4   H  N N 32  
A1A79 H5   H  N N 33  
A1A79 H6   H  N N 34  
A1A79 H7   H  N N 35  
A1A79 H8   H  N N 36  
A1A79 H9   H  N N 37  
A1A79 H10  H  N N 38  
A1A79 H11  H  N N 39  
A1A79 H12  H  N N 40  
A1A79 H13  H  N N 41  
A1A79 H14  H  N N 42  
A1A79 H15  H  N N 43  
A1A79 H16  H  N N 44  
A1A79 H17  H  N N 45  
A1A79 H18  H  N N 46  
ALA   N    N  N N 47  
ALA   CA   C  N S 48  
ALA   C    C  N N 49  
ALA   O    O  N N 50  
ALA   CB   C  N N 51  
ALA   OXT  O  N N 52  
ALA   H    H  N N 53  
ALA   H2   H  N N 54  
ALA   HA   H  N N 55  
ALA   HB1  H  N N 56  
ALA   HB2  H  N N 57  
ALA   HB3  H  N N 58  
ALA   HXT  H  N N 59  
ARG   N    N  N N 60  
ARG   CA   C  N S 61  
ARG   C    C  N N 62  
ARG   O    O  N N 63  
ARG   CB   C  N N 64  
ARG   CG   C  N N 65  
ARG   CD   C  N N 66  
ARG   NE   N  N N 67  
ARG   CZ   C  N N 68  
ARG   NH1  N  N N 69  
ARG   NH2  N  N N 70  
ARG   OXT  O  N N 71  
ARG   H    H  N N 72  
ARG   H2   H  N N 73  
ARG   HA   H  N N 74  
ARG   HB2  H  N N 75  
ARG   HB3  H  N N 76  
ARG   HG2  H  N N 77  
ARG   HG3  H  N N 78  
ARG   HD2  H  N N 79  
ARG   HD3  H  N N 80  
ARG   HE   H  N N 81  
ARG   HH11 H  N N 82  
ARG   HH12 H  N N 83  
ARG   HH21 H  N N 84  
ARG   HH22 H  N N 85  
ARG   HXT  H  N N 86  
ASN   N    N  N N 87  
ASN   CA   C  N S 88  
ASN   C    C  N N 89  
ASN   O    O  N N 90  
ASN   CB   C  N N 91  
ASN   CG   C  N N 92  
ASN   OD1  O  N N 93  
ASN   ND2  N  N N 94  
ASN   OXT  O  N N 95  
ASN   H    H  N N 96  
ASN   H2   H  N N 97  
ASN   HA   H  N N 98  
ASN   HB2  H  N N 99  
ASN   HB3  H  N N 100 
ASN   HD21 H  N N 101 
ASN   HD22 H  N N 102 
ASN   HXT  H  N N 103 
ASP   N    N  N N 104 
ASP   CA   C  N S 105 
ASP   C    C  N N 106 
ASP   O    O  N N 107 
ASP   CB   C  N N 108 
ASP   CG   C  N N 109 
ASP   OD1  O  N N 110 
ASP   OD2  O  N N 111 
ASP   OXT  O  N N 112 
ASP   H    H  N N 113 
ASP   H2   H  N N 114 
ASP   HA   H  N N 115 
ASP   HB2  H  N N 116 
ASP   HB3  H  N N 117 
ASP   HD2  H  N N 118 
ASP   HXT  H  N N 119 
CYS   N    N  N N 120 
CYS   CA   C  N R 121 
CYS   C    C  N N 122 
CYS   O    O  N N 123 
CYS   CB   C  N N 124 
CYS   SG   S  N N 125 
CYS   OXT  O  N N 126 
CYS   H    H  N N 127 
CYS   H2   H  N N 128 
CYS   HA   H  N N 129 
CYS   HB2  H  N N 130 
CYS   HB3  H  N N 131 
CYS   HG   H  N N 132 
CYS   HXT  H  N N 133 
EDO   C1   C  N N 134 
EDO   O1   O  N N 135 
EDO   C2   C  N N 136 
EDO   O2   O  N N 137 
EDO   H11  H  N N 138 
EDO   H12  H  N N 139 
EDO   HO1  H  N N 140 
EDO   H21  H  N N 141 
EDO   H22  H  N N 142 
EDO   HO2  H  N N 143 
GLN   N    N  N N 144 
GLN   CA   C  N S 145 
GLN   C    C  N N 146 
GLN   O    O  N N 147 
GLN   CB   C  N N 148 
GLN   CG   C  N N 149 
GLN   CD   C  N N 150 
GLN   OE1  O  N N 151 
GLN   NE2  N  N N 152 
GLN   OXT  O  N N 153 
GLN   H    H  N N 154 
GLN   H2   H  N N 155 
GLN   HA   H  N N 156 
GLN   HB2  H  N N 157 
GLN   HB3  H  N N 158 
GLN   HG2  H  N N 159 
GLN   HG3  H  N N 160 
GLN   HE21 H  N N 161 
GLN   HE22 H  N N 162 
GLN   HXT  H  N N 163 
GLU   N    N  N N 164 
GLU   CA   C  N S 165 
GLU   C    C  N N 166 
GLU   O    O  N N 167 
GLU   CB   C  N N 168 
GLU   CG   C  N N 169 
GLU   CD   C  N N 170 
GLU   OE1  O  N N 171 
GLU   OE2  O  N N 172 
GLU   OXT  O  N N 173 
GLU   H    H  N N 174 
GLU   H2   H  N N 175 
GLU   HA   H  N N 176 
GLU   HB2  H  N N 177 
GLU   HB3  H  N N 178 
GLU   HG2  H  N N 179 
GLU   HG3  H  N N 180 
GLU   HE2  H  N N 181 
GLU   HXT  H  N N 182 
GLY   N    N  N N 183 
GLY   CA   C  N N 184 
GLY   C    C  N N 185 
GLY   O    O  N N 186 
GLY   OXT  O  N N 187 
GLY   H    H  N N 188 
GLY   H2   H  N N 189 
GLY   HA2  H  N N 190 
GLY   HA3  H  N N 191 
GLY   HXT  H  N N 192 
HIS   N    N  N N 193 
HIS   CA   C  N S 194 
HIS   C    C  N N 195 
HIS   O    O  N N 196 
HIS   CB   C  N N 197 
HIS   CG   C  Y N 198 
HIS   ND1  N  Y N 199 
HIS   CD2  C  Y N 200 
HIS   CE1  C  Y N 201 
HIS   NE2  N  Y N 202 
HIS   OXT  O  N N 203 
HIS   H    H  N N 204 
HIS   H2   H  N N 205 
HIS   HA   H  N N 206 
HIS   HB2  H  N N 207 
HIS   HB3  H  N N 208 
HIS   HD1  H  N N 209 
HIS   HD2  H  N N 210 
HIS   HE1  H  N N 211 
HIS   HE2  H  N N 212 
HIS   HXT  H  N N 213 
HOH   O    O  N N 214 
HOH   H1   H  N N 215 
HOH   H2   H  N N 216 
ILE   N    N  N N 217 
ILE   CA   C  N S 218 
ILE   C    C  N N 219 
ILE   O    O  N N 220 
ILE   CB   C  N S 221 
ILE   CG1  C  N N 222 
ILE   CG2  C  N N 223 
ILE   CD1  C  N N 224 
ILE   OXT  O  N N 225 
ILE   H    H  N N 226 
ILE   H2   H  N N 227 
ILE   HA   H  N N 228 
ILE   HB   H  N N 229 
ILE   HG12 H  N N 230 
ILE   HG13 H  N N 231 
ILE   HG21 H  N N 232 
ILE   HG22 H  N N 233 
ILE   HG23 H  N N 234 
ILE   HD11 H  N N 235 
ILE   HD12 H  N N 236 
ILE   HD13 H  N N 237 
ILE   HXT  H  N N 238 
LEU   N    N  N N 239 
LEU   CA   C  N S 240 
LEU   C    C  N N 241 
LEU   O    O  N N 242 
LEU   CB   C  N N 243 
LEU   CG   C  N N 244 
LEU   CD1  C  N N 245 
LEU   CD2  C  N N 246 
LEU   OXT  O  N N 247 
LEU   H    H  N N 248 
LEU   H2   H  N N 249 
LEU   HA   H  N N 250 
LEU   HB2  H  N N 251 
LEU   HB3  H  N N 252 
LEU   HG   H  N N 253 
LEU   HD11 H  N N 254 
LEU   HD12 H  N N 255 
LEU   HD13 H  N N 256 
LEU   HD21 H  N N 257 
LEU   HD22 H  N N 258 
LEU   HD23 H  N N 259 
LEU   HXT  H  N N 260 
LYS   N    N  N N 261 
LYS   CA   C  N S 262 
LYS   C    C  N N 263 
LYS   O    O  N N 264 
LYS   CB   C  N N 265 
LYS   CG   C  N N 266 
LYS   CD   C  N N 267 
LYS   CE   C  N N 268 
LYS   NZ   N  N N 269 
LYS   OXT  O  N N 270 
LYS   H    H  N N 271 
LYS   H2   H  N N 272 
LYS   HA   H  N N 273 
LYS   HB2  H  N N 274 
LYS   HB3  H  N N 275 
LYS   HG2  H  N N 276 
LYS   HG3  H  N N 277 
LYS   HD2  H  N N 278 
LYS   HD3  H  N N 279 
LYS   HE2  H  N N 280 
LYS   HE3  H  N N 281 
LYS   HZ1  H  N N 282 
LYS   HZ2  H  N N 283 
LYS   HZ3  H  N N 284 
LYS   HXT  H  N N 285 
MET   N    N  N N 286 
MET   CA   C  N S 287 
MET   C    C  N N 288 
MET   O    O  N N 289 
MET   CB   C  N N 290 
MET   CG   C  N N 291 
MET   SD   S  N N 292 
MET   CE   C  N N 293 
MET   OXT  O  N N 294 
MET   H    H  N N 295 
MET   H2   H  N N 296 
MET   HA   H  N N 297 
MET   HB2  H  N N 298 
MET   HB3  H  N N 299 
MET   HG2  H  N N 300 
MET   HG3  H  N N 301 
MET   HE1  H  N N 302 
MET   HE2  H  N N 303 
MET   HE3  H  N N 304 
MET   HXT  H  N N 305 
PHE   N    N  N N 306 
PHE   CA   C  N S 307 
PHE   C    C  N N 308 
PHE   O    O  N N 309 
PHE   CB   C  N N 310 
PHE   CG   C  Y N 311 
PHE   CD1  C  Y N 312 
PHE   CD2  C  Y N 313 
PHE   CE1  C  Y N 314 
PHE   CE2  C  Y N 315 
PHE   CZ   C  Y N 316 
PHE   OXT  O  N N 317 
PHE   H    H  N N 318 
PHE   H2   H  N N 319 
PHE   HA   H  N N 320 
PHE   HB2  H  N N 321 
PHE   HB3  H  N N 322 
PHE   HD1  H  N N 323 
PHE   HD2  H  N N 324 
PHE   HE1  H  N N 325 
PHE   HE2  H  N N 326 
PHE   HZ   H  N N 327 
PHE   HXT  H  N N 328 
PRO   N    N  N N 329 
PRO   CA   C  N S 330 
PRO   C    C  N N 331 
PRO   O    O  N N 332 
PRO   CB   C  N N 333 
PRO   CG   C  N N 334 
PRO   CD   C  N N 335 
PRO   OXT  O  N N 336 
PRO   H    H  N N 337 
PRO   HA   H  N N 338 
PRO   HB2  H  N N 339 
PRO   HB3  H  N N 340 
PRO   HG2  H  N N 341 
PRO   HG3  H  N N 342 
PRO   HD2  H  N N 343 
PRO   HD3  H  N N 344 
PRO   HXT  H  N N 345 
SER   N    N  N N 346 
SER   CA   C  N S 347 
SER   C    C  N N 348 
SER   O    O  N N 349 
SER   CB   C  N N 350 
SER   OG   O  N N 351 
SER   OXT  O  N N 352 
SER   H    H  N N 353 
SER   H2   H  N N 354 
SER   HA   H  N N 355 
SER   HB2  H  N N 356 
SER   HB3  H  N N 357 
SER   HG   H  N N 358 
SER   HXT  H  N N 359 
THR   N    N  N N 360 
THR   CA   C  N S 361 
THR   C    C  N N 362 
THR   O    O  N N 363 
THR   CB   C  N R 364 
THR   OG1  O  N N 365 
THR   CG2  C  N N 366 
THR   OXT  O  N N 367 
THR   H    H  N N 368 
THR   H2   H  N N 369 
THR   HA   H  N N 370 
THR   HB   H  N N 371 
THR   HG1  H  N N 372 
THR   HG21 H  N N 373 
THR   HG22 H  N N 374 
THR   HG23 H  N N 375 
THR   HXT  H  N N 376 
TRP   N    N  N N 377 
TRP   CA   C  N S 378 
TRP   C    C  N N 379 
TRP   O    O  N N 380 
TRP   CB   C  N N 381 
TRP   CG   C  Y N 382 
TRP   CD1  C  Y N 383 
TRP   CD2  C  Y N 384 
TRP   NE1  N  Y N 385 
TRP   CE2  C  Y N 386 
TRP   CE3  C  Y N 387 
TRP   CZ2  C  Y N 388 
TRP   CZ3  C  Y N 389 
TRP   CH2  C  Y N 390 
TRP   OXT  O  N N 391 
TRP   H    H  N N 392 
TRP   H2   H  N N 393 
TRP   HA   H  N N 394 
TRP   HB2  H  N N 395 
TRP   HB3  H  N N 396 
TRP   HD1  H  N N 397 
TRP   HE1  H  N N 398 
TRP   HE3  H  N N 399 
TRP   HZ2  H  N N 400 
TRP   HZ3  H  N N 401 
TRP   HH2  H  N N 402 
TRP   HXT  H  N N 403 
TYR   N    N  N N 404 
TYR   CA   C  N S 405 
TYR   C    C  N N 406 
TYR   O    O  N N 407 
TYR   CB   C  N N 408 
TYR   CG   C  Y N 409 
TYR   CD1  C  Y N 410 
TYR   CD2  C  Y N 411 
TYR   CE1  C  Y N 412 
TYR   CE2  C  Y N 413 
TYR   CZ   C  Y N 414 
TYR   OH   O  N N 415 
TYR   OXT  O  N N 416 
TYR   H    H  N N 417 
TYR   H2   H  N N 418 
TYR   HA   H  N N 419 
TYR   HB2  H  N N 420 
TYR   HB3  H  N N 421 
TYR   HD1  H  N N 422 
TYR   HD2  H  N N 423 
TYR   HE1  H  N N 424 
TYR   HE2  H  N N 425 
TYR   HH   H  N N 426 
TYR   HXT  H  N N 427 
VAL   N    N  N N 428 
VAL   CA   C  N S 429 
VAL   C    C  N N 430 
VAL   O    O  N N 431 
VAL   CB   C  N N 432 
VAL   CG1  C  N N 433 
VAL   CG2  C  N N 434 
VAL   OXT  O  N N 435 
VAL   H    H  N N 436 
VAL   H2   H  N N 437 
VAL   HA   H  N N 438 
VAL   HB   H  N N 439 
VAL   HG11 H  N N 440 
VAL   HG12 H  N N 441 
VAL   HG13 H  N N 442 
VAL   HG21 H  N N 443 
VAL   HG22 H  N N 444 
VAL   HG23 H  N N 445 
VAL   HXT  H  N N 446 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1A79 CL1 C1   sing N N 1   
A1A79 CL2 C2   sing N N 2   
A1A79 C1  C6   doub Y N 3   
A1A79 C1  C2   sing Y N 4   
A1A79 C6  C5   sing Y N 5   
A1A79 C2  C3   doub Y N 6   
A1A79 O1  C7   sing N N 7   
A1A79 C5  C4   doub Y N 8   
A1A79 C5  C7   sing N N 9   
A1A79 C3  C4   sing Y N 10  
A1A79 C7  C8   sing N N 11  
A1A79 O2  C8   sing N N 12  
A1A79 O2  C11  sing N N 13  
A1A79 C8  C9   sing N N 14  
A1A79 C15 C14  doub Y N 15  
A1A79 C15 N1   sing Y N 16  
A1A79 C14 C13  sing Y N 17  
A1A79 N1  C11  sing N N 18  
A1A79 N1  C12  sing Y N 19  
A1A79 N4  C17  sing N N 20  
A1A79 C13 C17  doub Y N 21  
A1A79 C13 C12  sing Y N 22  
A1A79 C18 C9   sing N N 23  
A1A79 C9  C10  sing N N 24  
A1A79 C9  O4   sing N N 25  
A1A79 C11 C10  sing N N 26  
A1A79 C17 N3   sing Y N 27  
A1A79 C12 N2   doub Y N 28  
A1A79 C10 O3   sing N N 29  
A1A79 N3  C16  doub Y N 30  
A1A79 N2  C16  sing Y N 31  
A1A79 C4  H1   sing N N 32  
A1A79 C6  H2   sing N N 33  
A1A79 C7  H3   sing N N 34  
A1A79 C8  H4   sing N N 35  
A1A79 C10 H5   sing N N 36  
A1A79 C15 H6   sing N N 37  
A1A79 C3  H7   sing N N 38  
A1A79 O1  H8   sing N N 39  
A1A79 C11 H9   sing N N 40  
A1A79 O3  H10  sing N N 41  
A1A79 C14 H11  sing N N 42  
A1A79 C16 H12  sing N N 43  
A1A79 N4  H13  sing N N 44  
A1A79 N4  H14  sing N N 45  
A1A79 C18 H15  sing N N 46  
A1A79 C18 H16  sing N N 47  
A1A79 C18 H17  sing N N 48  
A1A79 O4  H18  sing N N 49  
ALA   N   CA   sing N N 50  
ALA   N   H    sing N N 51  
ALA   N   H2   sing N N 52  
ALA   CA  C    sing N N 53  
ALA   CA  CB   sing N N 54  
ALA   CA  HA   sing N N 55  
ALA   C   O    doub N N 56  
ALA   C   OXT  sing N N 57  
ALA   CB  HB1  sing N N 58  
ALA   CB  HB2  sing N N 59  
ALA   CB  HB3  sing N N 60  
ALA   OXT HXT  sing N N 61  
ARG   N   CA   sing N N 62  
ARG   N   H    sing N N 63  
ARG   N   H2   sing N N 64  
ARG   CA  C    sing N N 65  
ARG   CA  CB   sing N N 66  
ARG   CA  HA   sing N N 67  
ARG   C   O    doub N N 68  
ARG   C   OXT  sing N N 69  
ARG   CB  CG   sing N N 70  
ARG   CB  HB2  sing N N 71  
ARG   CB  HB3  sing N N 72  
ARG   CG  CD   sing N N 73  
ARG   CG  HG2  sing N N 74  
ARG   CG  HG3  sing N N 75  
ARG   CD  NE   sing N N 76  
ARG   CD  HD2  sing N N 77  
ARG   CD  HD3  sing N N 78  
ARG   NE  CZ   sing N N 79  
ARG   NE  HE   sing N N 80  
ARG   CZ  NH1  sing N N 81  
ARG   CZ  NH2  doub N N 82  
ARG   NH1 HH11 sing N N 83  
ARG   NH1 HH12 sing N N 84  
ARG   NH2 HH21 sing N N 85  
ARG   NH2 HH22 sing N N 86  
ARG   OXT HXT  sing N N 87  
ASN   N   CA   sing N N 88  
ASN   N   H    sing N N 89  
ASN   N   H2   sing N N 90  
ASN   CA  C    sing N N 91  
ASN   CA  CB   sing N N 92  
ASN   CA  HA   sing N N 93  
ASN   C   O    doub N N 94  
ASN   C   OXT  sing N N 95  
ASN   CB  CG   sing N N 96  
ASN   CB  HB2  sing N N 97  
ASN   CB  HB3  sing N N 98  
ASN   CG  OD1  doub N N 99  
ASN   CG  ND2  sing N N 100 
ASN   ND2 HD21 sing N N 101 
ASN   ND2 HD22 sing N N 102 
ASN   OXT HXT  sing N N 103 
ASP   N   CA   sing N N 104 
ASP   N   H    sing N N 105 
ASP   N   H2   sing N N 106 
ASP   CA  C    sing N N 107 
ASP   CA  CB   sing N N 108 
ASP   CA  HA   sing N N 109 
ASP   C   O    doub N N 110 
ASP   C   OXT  sing N N 111 
ASP   CB  CG   sing N N 112 
ASP   CB  HB2  sing N N 113 
ASP   CB  HB3  sing N N 114 
ASP   CG  OD1  doub N N 115 
ASP   CG  OD2  sing N N 116 
ASP   OD2 HD2  sing N N 117 
ASP   OXT HXT  sing N N 118 
CYS   N   CA   sing N N 119 
CYS   N   H    sing N N 120 
CYS   N   H2   sing N N 121 
CYS   CA  C    sing N N 122 
CYS   CA  CB   sing N N 123 
CYS   CA  HA   sing N N 124 
CYS   C   O    doub N N 125 
CYS   C   OXT  sing N N 126 
CYS   CB  SG   sing N N 127 
CYS   CB  HB2  sing N N 128 
CYS   CB  HB3  sing N N 129 
CYS   SG  HG   sing N N 130 
CYS   OXT HXT  sing N N 131 
EDO   C1  O1   sing N N 132 
EDO   C1  C2   sing N N 133 
EDO   C1  H11  sing N N 134 
EDO   C1  H12  sing N N 135 
EDO   O1  HO1  sing N N 136 
EDO   C2  O2   sing N N 137 
EDO   C2  H21  sing N N 138 
EDO   C2  H22  sing N N 139 
EDO   O2  HO2  sing N N 140 
GLN   N   CA   sing N N 141 
GLN   N   H    sing N N 142 
GLN   N   H2   sing N N 143 
GLN   CA  C    sing N N 144 
GLN   CA  CB   sing N N 145 
GLN   CA  HA   sing N N 146 
GLN   C   O    doub N N 147 
GLN   C   OXT  sing N N 148 
GLN   CB  CG   sing N N 149 
GLN   CB  HB2  sing N N 150 
GLN   CB  HB3  sing N N 151 
GLN   CG  CD   sing N N 152 
GLN   CG  HG2  sing N N 153 
GLN   CG  HG3  sing N N 154 
GLN   CD  OE1  doub N N 155 
GLN   CD  NE2  sing N N 156 
GLN   NE2 HE21 sing N N 157 
GLN   NE2 HE22 sing N N 158 
GLN   OXT HXT  sing N N 159 
GLU   N   CA   sing N N 160 
GLU   N   H    sing N N 161 
GLU   N   H2   sing N N 162 
GLU   CA  C    sing N N 163 
GLU   CA  CB   sing N N 164 
GLU   CA  HA   sing N N 165 
GLU   C   O    doub N N 166 
GLU   C   OXT  sing N N 167 
GLU   CB  CG   sing N N 168 
GLU   CB  HB2  sing N N 169 
GLU   CB  HB3  sing N N 170 
GLU   CG  CD   sing N N 171 
GLU   CG  HG2  sing N N 172 
GLU   CG  HG3  sing N N 173 
GLU   CD  OE1  doub N N 174 
GLU   CD  OE2  sing N N 175 
GLU   OE2 HE2  sing N N 176 
GLU   OXT HXT  sing N N 177 
GLY   N   CA   sing N N 178 
GLY   N   H    sing N N 179 
GLY   N   H2   sing N N 180 
GLY   CA  C    sing N N 181 
GLY   CA  HA2  sing N N 182 
GLY   CA  HA3  sing N N 183 
GLY   C   O    doub N N 184 
GLY   C   OXT  sing N N 185 
GLY   OXT HXT  sing N N 186 
HIS   N   CA   sing N N 187 
HIS   N   H    sing N N 188 
HIS   N   H2   sing N N 189 
HIS   CA  C    sing N N 190 
HIS   CA  CB   sing N N 191 
HIS   CA  HA   sing N N 192 
HIS   C   O    doub N N 193 
HIS   C   OXT  sing N N 194 
HIS   CB  CG   sing N N 195 
HIS   CB  HB2  sing N N 196 
HIS   CB  HB3  sing N N 197 
HIS   CG  ND1  sing Y N 198 
HIS   CG  CD2  doub Y N 199 
HIS   ND1 CE1  doub Y N 200 
HIS   ND1 HD1  sing N N 201 
HIS   CD2 NE2  sing Y N 202 
HIS   CD2 HD2  sing N N 203 
HIS   CE1 NE2  sing Y N 204 
HIS   CE1 HE1  sing N N 205 
HIS   NE2 HE2  sing N N 206 
HIS   OXT HXT  sing N N 207 
HOH   O   H1   sing N N 208 
HOH   O   H2   sing N N 209 
ILE   N   CA   sing N N 210 
ILE   N   H    sing N N 211 
ILE   N   H2   sing N N 212 
ILE   CA  C    sing N N 213 
ILE   CA  CB   sing N N 214 
ILE   CA  HA   sing N N 215 
ILE   C   O    doub N N 216 
ILE   C   OXT  sing N N 217 
ILE   CB  CG1  sing N N 218 
ILE   CB  CG2  sing N N 219 
ILE   CB  HB   sing N N 220 
ILE   CG1 CD1  sing N N 221 
ILE   CG1 HG12 sing N N 222 
ILE   CG1 HG13 sing N N 223 
ILE   CG2 HG21 sing N N 224 
ILE   CG2 HG22 sing N N 225 
ILE   CG2 HG23 sing N N 226 
ILE   CD1 HD11 sing N N 227 
ILE   CD1 HD12 sing N N 228 
ILE   CD1 HD13 sing N N 229 
ILE   OXT HXT  sing N N 230 
LEU   N   CA   sing N N 231 
LEU   N   H    sing N N 232 
LEU   N   H2   sing N N 233 
LEU   CA  C    sing N N 234 
LEU   CA  CB   sing N N 235 
LEU   CA  HA   sing N N 236 
LEU   C   O    doub N N 237 
LEU   C   OXT  sing N N 238 
LEU   CB  CG   sing N N 239 
LEU   CB  HB2  sing N N 240 
LEU   CB  HB3  sing N N 241 
LEU   CG  CD1  sing N N 242 
LEU   CG  CD2  sing N N 243 
LEU   CG  HG   sing N N 244 
LEU   CD1 HD11 sing N N 245 
LEU   CD1 HD12 sing N N 246 
LEU   CD1 HD13 sing N N 247 
LEU   CD2 HD21 sing N N 248 
LEU   CD2 HD22 sing N N 249 
LEU   CD2 HD23 sing N N 250 
LEU   OXT HXT  sing N N 251 
LYS   N   CA   sing N N 252 
LYS   N   H    sing N N 253 
LYS   N   H2   sing N N 254 
LYS   CA  C    sing N N 255 
LYS   CA  CB   sing N N 256 
LYS   CA  HA   sing N N 257 
LYS   C   O    doub N N 258 
LYS   C   OXT  sing N N 259 
LYS   CB  CG   sing N N 260 
LYS   CB  HB2  sing N N 261 
LYS   CB  HB3  sing N N 262 
LYS   CG  CD   sing N N 263 
LYS   CG  HG2  sing N N 264 
LYS   CG  HG3  sing N N 265 
LYS   CD  CE   sing N N 266 
LYS   CD  HD2  sing N N 267 
LYS   CD  HD3  sing N N 268 
LYS   CE  NZ   sing N N 269 
LYS   CE  HE2  sing N N 270 
LYS   CE  HE3  sing N N 271 
LYS   NZ  HZ1  sing N N 272 
LYS   NZ  HZ2  sing N N 273 
LYS   NZ  HZ3  sing N N 274 
LYS   OXT HXT  sing N N 275 
MET   N   CA   sing N N 276 
MET   N   H    sing N N 277 
MET   N   H2   sing N N 278 
MET   CA  C    sing N N 279 
MET   CA  CB   sing N N 280 
MET   CA  HA   sing N N 281 
MET   C   O    doub N N 282 
MET   C   OXT  sing N N 283 
MET   CB  CG   sing N N 284 
MET   CB  HB2  sing N N 285 
MET   CB  HB3  sing N N 286 
MET   CG  SD   sing N N 287 
MET   CG  HG2  sing N N 288 
MET   CG  HG3  sing N N 289 
MET   SD  CE   sing N N 290 
MET   CE  HE1  sing N N 291 
MET   CE  HE2  sing N N 292 
MET   CE  HE3  sing N N 293 
MET   OXT HXT  sing N N 294 
PHE   N   CA   sing N N 295 
PHE   N   H    sing N N 296 
PHE   N   H2   sing N N 297 
PHE   CA  C    sing N N 298 
PHE   CA  CB   sing N N 299 
PHE   CA  HA   sing N N 300 
PHE   C   O    doub N N 301 
PHE   C   OXT  sing N N 302 
PHE   CB  CG   sing N N 303 
PHE   CB  HB2  sing N N 304 
PHE   CB  HB3  sing N N 305 
PHE   CG  CD1  doub Y N 306 
PHE   CG  CD2  sing Y N 307 
PHE   CD1 CE1  sing Y N 308 
PHE   CD1 HD1  sing N N 309 
PHE   CD2 CE2  doub Y N 310 
PHE   CD2 HD2  sing N N 311 
PHE   CE1 CZ   doub Y N 312 
PHE   CE1 HE1  sing N N 313 
PHE   CE2 CZ   sing Y N 314 
PHE   CE2 HE2  sing N N 315 
PHE   CZ  HZ   sing N N 316 
PHE   OXT HXT  sing N N 317 
PRO   N   CA   sing N N 318 
PRO   N   CD   sing N N 319 
PRO   N   H    sing N N 320 
PRO   CA  C    sing N N 321 
PRO   CA  CB   sing N N 322 
PRO   CA  HA   sing N N 323 
PRO   C   O    doub N N 324 
PRO   C   OXT  sing N N 325 
PRO   CB  CG   sing N N 326 
PRO   CB  HB2  sing N N 327 
PRO   CB  HB3  sing N N 328 
PRO   CG  CD   sing N N 329 
PRO   CG  HG2  sing N N 330 
PRO   CG  HG3  sing N N 331 
PRO   CD  HD2  sing N N 332 
PRO   CD  HD3  sing N N 333 
PRO   OXT HXT  sing N N 334 
SER   N   CA   sing N N 335 
SER   N   H    sing N N 336 
SER   N   H2   sing N N 337 
SER   CA  C    sing N N 338 
SER   CA  CB   sing N N 339 
SER   CA  HA   sing N N 340 
SER   C   O    doub N N 341 
SER   C   OXT  sing N N 342 
SER   CB  OG   sing N N 343 
SER   CB  HB2  sing N N 344 
SER   CB  HB3  sing N N 345 
SER   OG  HG   sing N N 346 
SER   OXT HXT  sing N N 347 
THR   N   CA   sing N N 348 
THR   N   H    sing N N 349 
THR   N   H2   sing N N 350 
THR   CA  C    sing N N 351 
THR   CA  CB   sing N N 352 
THR   CA  HA   sing N N 353 
THR   C   O    doub N N 354 
THR   C   OXT  sing N N 355 
THR   CB  OG1  sing N N 356 
THR   CB  CG2  sing N N 357 
THR   CB  HB   sing N N 358 
THR   OG1 HG1  sing N N 359 
THR   CG2 HG21 sing N N 360 
THR   CG2 HG22 sing N N 361 
THR   CG2 HG23 sing N N 362 
THR   OXT HXT  sing N N 363 
TRP   N   CA   sing N N 364 
TRP   N   H    sing N N 365 
TRP   N   H2   sing N N 366 
TRP   CA  C    sing N N 367 
TRP   CA  CB   sing N N 368 
TRP   CA  HA   sing N N 369 
TRP   C   O    doub N N 370 
TRP   C   OXT  sing N N 371 
TRP   CB  CG   sing N N 372 
TRP   CB  HB2  sing N N 373 
TRP   CB  HB3  sing N N 374 
TRP   CG  CD1  doub Y N 375 
TRP   CG  CD2  sing Y N 376 
TRP   CD1 NE1  sing Y N 377 
TRP   CD1 HD1  sing N N 378 
TRP   CD2 CE2  doub Y N 379 
TRP   CD2 CE3  sing Y N 380 
TRP   NE1 CE2  sing Y N 381 
TRP   NE1 HE1  sing N N 382 
TRP   CE2 CZ2  sing Y N 383 
TRP   CE3 CZ3  doub Y N 384 
TRP   CE3 HE3  sing N N 385 
TRP   CZ2 CH2  doub Y N 386 
TRP   CZ2 HZ2  sing N N 387 
TRP   CZ3 CH2  sing Y N 388 
TRP   CZ3 HZ3  sing N N 389 
TRP   CH2 HH2  sing N N 390 
TRP   OXT HXT  sing N N 391 
TYR   N   CA   sing N N 392 
TYR   N   H    sing N N 393 
TYR   N   H2   sing N N 394 
TYR   CA  C    sing N N 395 
TYR   CA  CB   sing N N 396 
TYR   CA  HA   sing N N 397 
TYR   C   O    doub N N 398 
TYR   C   OXT  sing N N 399 
TYR   CB  CG   sing N N 400 
TYR   CB  HB2  sing N N 401 
TYR   CB  HB3  sing N N 402 
TYR   CG  CD1  doub Y N 403 
TYR   CG  CD2  sing Y N 404 
TYR   CD1 CE1  sing Y N 405 
TYR   CD1 HD1  sing N N 406 
TYR   CD2 CE2  doub Y N 407 
TYR   CD2 HD2  sing N N 408 
TYR   CE1 CZ   doub Y N 409 
TYR   CE1 HE1  sing N N 410 
TYR   CE2 CZ   sing Y N 411 
TYR   CE2 HE2  sing N N 412 
TYR   CZ  OH   sing N N 413 
TYR   OH  HH   sing N N 414 
TYR   OXT HXT  sing N N 415 
VAL   N   CA   sing N N 416 
VAL   N   H    sing N N 417 
VAL   N   H2   sing N N 418 
VAL   CA  C    sing N N 419 
VAL   CA  CB   sing N N 420 
VAL   CA  HA   sing N N 421 
VAL   C   O    doub N N 422 
VAL   C   OXT  sing N N 423 
VAL   CB  CG1  sing N N 424 
VAL   CB  CG2  sing N N 425 
VAL   CB  HB   sing N N 426 
VAL   CG1 HG11 sing N N 427 
VAL   CG1 HG12 sing N N 428 
VAL   CG1 HG13 sing N N 429 
VAL   CG2 HG21 sing N N 430 
VAL   CG2 HG22 sing N N 431 
VAL   CG2 HG23 sing N N 432 
VAL   OXT HXT  sing N N 433 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4GQB 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9DOD 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009750 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007184 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005601 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER   A 1 11  ? -39.225 -72.296  -15.881 1.00 136.45 ? 12   SER   A N   1 
ATOM   2    C  CA  . SER   A 1 11  ? -39.283 -70.810  -15.719 1.00 135.66 ? 12   SER   A CA  1 
ATOM   3    C  C   . SER   A 1 11  ? -39.488 -70.145  -17.087 1.00 137.17 ? 12   SER   A C   1 
ATOM   4    O  O   . SER   A 1 11  ? -38.805 -70.555  -18.047 1.00 133.72 ? 12   SER   A O   1 
ATOM   5    C  CB  . SER   A 1 11  ? -38.039 -70.295  -15.035 1.00 131.08 ? 12   SER   A CB  1 
ATOM   6    O  OG  . SER   A 1 11  ? -38.182 -68.928  -14.678 1.00 124.70 ? 12   SER   A OG  1 
ATOM   7    N  N   . ARG   A 1 12  ? -40.401 -69.170  -17.169 1.00 140.33 ? 13   ARG   A N   1 
ATOM   8    C  CA  . ARG   A 1 12  ? -40.643 -68.338  -18.384 1.00 138.17 ? 13   ARG   A CA  1 
ATOM   9    C  C   . ARG   A 1 12  ? -39.375 -67.528  -18.683 1.00 134.65 ? 13   ARG   A C   1 
ATOM   10   O  O   . ARG   A 1 12  ? -38.520 -67.422  -17.778 1.00 140.78 ? 13   ARG   A O   1 
ATOM   11   C  CB  . ARG   A 1 12  ? -41.870 -67.437  -18.192 1.00 138.85 ? 13   ARG   A CB  1 
ATOM   12   C  CG  . ARG   A 1 12  ? -41.713 -66.361  -17.125 1.00 141.29 ? 13   ARG   A CG  1 
ATOM   13   C  CD  . ARG   A 1 12  ? -42.998 -65.584  -16.912 1.00 145.42 ? 13   ARG   A CD  1 
ATOM   14   N  NE  . ARG   A 1 12  ? -42.860 -64.529  -15.913 1.00 148.50 ? 13   ARG   A NE  1 
ATOM   15   C  CZ  . ARG   A 1 12  ? -42.347 -63.318  -16.133 1.00 149.62 ? 13   ARG   A CZ  1 
ATOM   16   N  NH1 . ARG   A 1 12  ? -41.896 -62.977  -17.330 1.00 152.36 ? 13   ARG   A NH1 1 
ATOM   17   N  NH2 . ARG   A 1 12  ? -42.283 -62.445  -15.142 1.00 146.39 ? 13   ARG   A NH2 1 
ATOM   18   N  N   . VAL   A 1 13  ? -39.255 -66.976  -19.897 1.00 121.10 ? 14   VAL   A N   1 
ATOM   19   C  CA  . VAL   A 1 13  ? -38.032 -66.255  -20.366 1.00 110.68 ? 14   VAL   A CA  1 
ATOM   20   C  C   . VAL   A 1 13  ? -37.901 -64.940  -19.592 1.00 102.77 ? 14   VAL   A C   1 
ATOM   21   O  O   . VAL   A 1 13  ? -38.925 -64.245  -19.427 1.00 99.18  ? 14   VAL   A O   1 
ATOM   22   C  CB  . VAL   A 1 13  ? -38.039 -65.988  -21.884 1.00 112.36 ? 14   VAL   A CB  1 
ATOM   23   C  CG1 . VAL   A 1 13  ? -38.273 -67.261  -22.674 1.00 115.78 ? 14   VAL   A CG1 1 
ATOM   24   C  CG2 . VAL   A 1 13  ? -39.045 -64.919  -22.284 1.00 112.89 ? 14   VAL   A CG2 1 
ATOM   25   N  N   . SER   A 1 14  ? -36.683 -64.623  -19.141 1.00 94.34  ? 15   SER   A N   1 
ATOM   26   C  CA  . SER   A 1 14  ? -36.316 -63.312  -18.548 1.00 86.47  ? 15   SER   A CA  1 
ATOM   27   C  C   . SER   A 1 14  ? -35.974 -62.351  -19.688 1.00 81.10  ? 15   SER   A C   1 
ATOM   28   O  O   . SER   A 1 14  ? -35.156 -62.734  -20.543 1.00 80.59  ? 15   SER   A O   1 
ATOM   29   C  CB  . SER   A 1 14  ? -35.182 -63.442  -17.576 1.00 85.94  ? 15   SER   A CB  1 
ATOM   30   O  OG  . SER   A 1 14  ? -35.015 -62.238  -16.843 1.00 83.56  ? 15   SER   A OG  1 
ATOM   31   N  N   . SER   A 1 15  ? -36.595 -61.168  -19.698 1.00 78.33  ? 16   SER   A N   1 
ATOM   32   C  CA  . SER   A 1 15  ? -36.555 -60.197  -20.821 1.00 76.48  ? 16   SER   A CA  1 
ATOM   33   C  C   . SER   A 1 15  ? -36.448 -58.765  -20.292 1.00 74.97  ? 16   SER   A C   1 
ATOM   34   O  O   . SER   A 1 15  ? -37.187 -58.420  -19.350 1.00 75.14  ? 16   SER   A O   1 
ATOM   35   C  CB  . SER   A 1 15  ? -37.763 -60.351  -21.701 1.00 81.27  ? 16   SER   A CB  1 
ATOM   36   O  OG  . SER   A 1 15  ? -37.616 -61.457  -22.579 1.00 85.26  ? 16   SER   A OG  1 
ATOM   37   N  N   . GLY   A 1 16  ? -35.569 -57.965  -20.900 1.00 70.73  ? 17   GLY   A N   1 
ATOM   38   C  CA  . GLY   A 1 16  ? -35.384 -56.541  -20.578 1.00 67.35  ? 17   GLY   A CA  1 
ATOM   39   C  C   . GLY   A 1 16  ? -35.621 -55.670  -21.796 1.00 69.05  ? 17   GLY   A C   1 
ATOM   40   O  O   . GLY   A 1 16  ? -35.558 -56.196  -22.926 1.00 67.72  ? 17   GLY   A O   1 
ATOM   41   N  N   . ARG   A 1 17  ? -35.898 -54.386  -21.568 1.00 69.04  ? 18   ARG   A N   1 
ATOM   42   C  CA  . ARG   A 1 17  ? -36.075 -53.361  -22.627 1.00 69.00  ? 18   ARG   A CA  1 
ATOM   43   C  C   . ARG   A 1 17  ? -34.795 -52.525  -22.698 1.00 67.32  ? 18   ARG   A C   1 
ATOM   44   O  O   . ARG   A 1 17  ? -34.275 -52.159  -21.629 1.00 66.64  ? 18   ARG   A O   1 
ATOM   45   C  CB  . ARG   A 1 17  ? -37.302 -52.498  -22.313 1.00 71.83  ? 18   ARG   A CB  1 
ATOM   46   C  CG  . ARG   A 1 17  ? -37.563 -51.384  -23.317 1.00 75.63  ? 18   ARG   A CG  1 
ATOM   47   C  CD  . ARG   A 1 17  ? -38.225 -51.880  -24.588 1.00 77.45  ? 18   ARG   A CD  1 
ATOM   48   N  NE  . ARG   A 1 17  ? -38.397 -50.795  -25.547 1.00 78.62  ? 18   ARG   A NE  1 
ATOM   49   C  CZ  . ARG   A 1 17  ? -37.666 -50.599  -26.646 1.00 81.27  ? 18   ARG   A CZ  1 
ATOM   50   N  NH1 . ARG   A 1 17  ? -36.693 -51.432  -26.984 1.00 83.12  ? 18   ARG   A NH1 1 
ATOM   51   N  NH2 . ARG   A 1 17  ? -37.930 -49.566  -27.427 1.00 81.83  ? 18   ARG   A NH2 1 
ATOM   52   N  N   . ASP   A 1 18  ? -34.313 -52.239  -23.909 1.00 65.07  ? 19   ASP   A N   1 
ATOM   53   C  CA  . ASP   A 1 18  ? -33.147 -51.351  -24.142 1.00 65.40  ? 19   ASP   A CA  1 
ATOM   54   C  C   . ASP   A 1 18  ? -33.644 -50.029  -24.737 1.00 65.52  ? 19   ASP   A C   1 
ATOM   55   O  O   . ASP   A 1 18  ? -34.171 -50.050  -25.862 1.00 68.74  ? 19   ASP   A O   1 
ATOM   56   C  CB  . ASP   A 1 18  ? -32.104 -52.016  -25.043 1.00 65.27  ? 19   ASP   A CB  1 
ATOM   57   C  CG  . ASP   A 1 18  ? -30.915 -51.119  -25.354 1.00 65.38  ? 19   ASP   A CG  1 
ATOM   58   O  OD1 . ASP   A 1 18  ? -30.338 -50.552  -24.401 1.00 64.10  ? 19   ASP   A OD1 1 
ATOM   59   O  OD2 . ASP   A 1 18  ? -30.592 -50.973  -26.545 1.00 62.23  ? 19   ASP   A OD2 1 
ATOM   60   N  N   . LEU   A 1 19  ? -33.470 -48.931  -24.000 1.00 65.32  ? 20   LEU   A N   1 
ATOM   61   C  CA  . LEU   A 1 19  ? -33.740 -47.545  -24.461 1.00 68.29  ? 20   LEU   A CA  1 
ATOM   62   C  C   . LEU   A 1 19  ? -32.438 -46.752  -24.378 1.00 68.62  ? 20   LEU   A C   1 
ATOM   63   O  O   . LEU   A 1 19  ? -31.635 -47.049  -23.475 1.00 70.03  ? 20   LEU   A O   1 
ATOM   64   C  CB  . LEU   A 1 19  ? -34.801 -46.892  -23.569 1.00 72.75  ? 20   LEU   A CB  1 
ATOM   65   C  CG  . LEU   A 1 19  ? -36.023 -47.744  -23.232 1.00 74.81  ? 20   LEU   A CG  1 
ATOM   66   C  CD1 . LEU   A 1 19  ? -36.896 -47.037  -22.206 1.00 76.30  ? 20   LEU   A CD1 1 
ATOM   67   C  CD2 . LEU   A 1 19  ? -36.822 -48.066  -24.484 1.00 75.63  ? 20   LEU   A CD2 1 
ATOM   68   N  N   . ASN   A 1 20  ? -32.257 -45.774  -25.267 1.00 68.57  ? 21   ASN   A N   1 
ATOM   69   C  CA  . ASN   A 1 20  ? -31.179 -44.756  -25.164 1.00 69.36  ? 21   ASN   A CA  1 
ATOM   70   C  C   . ASN   A 1 20  ? -31.827 -43.390  -24.898 1.00 65.81  ? 21   ASN   A C   1 
ATOM   71   O  O   . ASN   A 1 20  ? -31.159 -42.371  -25.134 1.00 64.20  ? 21   ASN   A O   1 
ATOM   72   C  CB  . ASN   A 1 20  ? -30.274 -44.773  -26.401 1.00 70.66  ? 21   ASN   A CB  1 
ATOM   73   C  CG  . ASN   A 1 20  ? -28.831 -44.430  -26.085 1.00 69.90  ? 21   ASN   A CG  1 
ATOM   74   O  OD1 . ASN   A 1 20  ? -28.298 -44.855  -25.062 1.00 69.77  ? 21   ASN   A OD1 1 
ATOM   75   N  ND2 . ASN   A 1 20  ? -28.187 -43.670  -26.957 1.00 68.47  ? 21   ASN   A ND2 1 
ATOM   76   N  N   . CYS   A 1 21  ? -33.068 -43.378  -24.396 1.00 64.78  ? 22   CYS   A N   1 
ATOM   77   C  CA  . CYS   A 1 21  ? -33.860 -42.148  -24.117 1.00 68.44  ? 22   CYS   A CA  1 
ATOM   78   C  C   . CYS   A 1 21  ? -34.873 -42.399  -22.991 1.00 67.06  ? 22   CYS   A C   1 
ATOM   79   O  O   . CYS   A 1 21  ? -35.819 -43.186  -23.209 1.00 64.30  ? 22   CYS   A O   1 
ATOM   80   C  CB  . CYS   A 1 21  ? -34.591 -41.667  -25.365 1.00 71.98  ? 22   CYS   A CB  1 
ATOM   81   S  SG  . CYS   A 1 21  ? -35.746 -40.304  -25.055 1.00 72.59  ? 22   CYS   A SG  1 
ATOM   82   N  N   . VAL   A 1 22  ? -34.675 -41.734  -21.846 1.00 65.56  ? 23   VAL   A N   1 
ATOM   83   C  CA  . VAL   A 1 22  ? -35.532 -41.822  -20.626 1.00 68.40  ? 23   VAL   A CA  1 
ATOM   84   C  C   . VAL   A 1 22  ? -35.740 -40.407  -20.095 1.00 70.63  ? 23   VAL   A C   1 
ATOM   85   O  O   . VAL   A 1 22  ? -34.895 -39.897  -19.363 1.00 71.53  ? 23   VAL   A O   1 
ATOM   86   C  CB  . VAL   A 1 22  ? -34.901 -42.737  -19.558 1.00 67.88  ? 23   VAL   A CB  1 
ATOM   87   C  CG1 . VAL   A 1 22  ? -35.701 -42.744  -18.264 1.00 66.93  ? 23   VAL   A CG1 1 
ATOM   88   C  CG2 . VAL   A 1 22  ? -34.716 -44.154  -20.076 1.00 68.00  ? 23   VAL   A CG2 1 
ATOM   89   N  N   . PRO   A 1 23  ? -36.854 -39.726  -20.460 1.00 74.11  ? 24   PRO   A N   1 
ATOM   90   C  CA  . PRO   A 1 23  ? -37.145 -38.383  -19.954 1.00 71.32  ? 24   PRO   A CA  1 
ATOM   91   C  C   . PRO   A 1 23  ? -37.407 -38.377  -18.442 1.00 69.76  ? 24   PRO   A C   1 
ATOM   92   O  O   . PRO   A 1 23  ? -36.870 -37.528  -17.771 1.00 65.27  ? 24   PRO   A O   1 
ATOM   93   C  CB  . PRO   A 1 23  ? -38.411 -37.945  -20.708 1.00 72.47  ? 24   PRO   A CB  1 
ATOM   94   C  CG  . PRO   A 1 23  ? -38.532 -38.916  -21.870 1.00 74.94  ? 24   PRO   A CG  1 
ATOM   95   C  CD  . PRO   A 1 23  ? -37.884 -40.200  -21.398 1.00 74.65  ? 24   PRO   A CD  1 
ATOM   96   N  N   . GLU   A 1 24  ? -38.229 -39.319  -17.968 1.00 74.96  ? 25   GLU   A N   1 
ATOM   97   C  CA  . GLU   A 1 24  ? -38.546 -39.548  -16.533 1.00 77.83  ? 25   GLU   A CA  1 
ATOM   98   C  C   . GLU   A 1 24  ? -38.312 -41.031  -16.227 1.00 74.56  ? 25   GLU   A C   1 
ATOM   99   O  O   . GLU   A 1 24  ? -38.896 -41.865  -16.942 1.00 72.73  ? 25   GLU   A O   1 
ATOM   100  C  CB  . GLU   A 1 24  ? -39.998 -39.153  -16.253 1.00 87.02  ? 25   GLU   A CB  1 
ATOM   101  C  CG  . GLU   A 1 24  ? -40.282 -38.811  -14.797 1.00 96.07  ? 25   GLU   A CG  1 
ATOM   102  C  CD  . GLU   A 1 24  ? -40.069 -37.356  -14.408 1.00 102.82 ? 25   GLU   A CD  1 
ATOM   103  O  OE1 . GLU   A 1 24  ? -40.283 -36.467  -15.263 1.00 101.73 ? 25   GLU   A OE1 1 
ATOM   104  O  OE2 . GLU   A 1 24  ? -39.690 -37.112  -13.243 1.00 112.27 ? 25   GLU   A OE2 1 
ATOM   105  N  N   . ILE   A 1 25  ? -37.489 -41.351  -15.221 1.00 74.12  ? 26   ILE   A N   1 
ATOM   106  C  CA  . ILE   A 1 25  ? -37.193 -42.762  -14.821 1.00 76.87  ? 26   ILE   A CA  1 
ATOM   107  C  C   . ILE   A 1 25  ? -38.494 -43.433  -14.364 1.00 74.09  ? 26   ILE   A C   1 
ATOM   108  O  O   . ILE   A 1 25  ? -38.801 -44.524  -14.877 1.00 70.16  ? 26   ILE   A O   1 
ATOM   109  C  CB  . ILE   A 1 25  ? -36.117 -42.847  -13.719 1.00 79.28  ? 26   ILE   A CB  1 
ATOM   110  C  CG1 . ILE   A 1 25  ? -34.768 -42.291  -14.183 1.00 79.92  ? 26   ILE   A CG1 1 
ATOM   111  C  CG2 . ILE   A 1 25  ? -35.997 -44.280  -13.212 1.00 80.97  ? 26   ILE   A CG2 1 
ATOM   112  C  CD1 . ILE   A 1 25  ? -33.569 -42.937  -13.515 1.00 82.80  ? 26   ILE   A CD1 1 
ATOM   113  N  N   . ALA   A 1 26  ? -39.197 -42.802  -13.418 1.00 76.43  ? 27   ALA   A N   1 
ATOM   114  C  CA  . ALA   A 1 26  ? -40.432 -43.303  -12.770 1.00 78.95  ? 27   ALA   A CA  1 
ATOM   115  C  C   . ALA   A 1 26  ? -41.413 -43.814  -13.830 1.00 79.13  ? 27   ALA   A C   1 
ATOM   116  O  O   . ALA   A 1 26  ? -41.772 -45.004  -13.767 1.00 75.63  ? 27   ALA   A O   1 
ATOM   117  C  CB  . ALA   A 1 26  ? -41.053 -42.209  -11.936 1.00 84.00  ? 27   ALA   A CB  1 
ATOM   118  N  N   . ASP   A 1 27  ? -41.812 -42.942  -14.766 1.00 81.74  ? 28   ASP   A N   1 
ATOM   119  C  CA  . ASP   A 1 27  ? -42.801 -43.240  -15.840 1.00 84.38  ? 28   ASP   A CA  1 
ATOM   120  C  C   . ASP   A 1 27  ? -42.255 -44.336  -16.759 1.00 81.41  ? 28   ASP   A C   1 
ATOM   121  O  O   . ASP   A 1 27  ? -43.000 -45.301  -17.038 1.00 81.66  ? 28   ASP   A O   1 
ATOM   122  C  CB  . ASP   A 1 27  ? -43.129 -42.007  -16.688 1.00 87.77  ? 28   ASP   A CB  1 
ATOM   123  C  CG  . ASP   A 1 27  ? -43.783 -40.865  -15.928 1.00 89.19  ? 28   ASP   A CG  1 
ATOM   124  O  OD1 . ASP   A 1 27  ? -44.426 -41.135  -14.887 1.00 84.67  ? 28   ASP   A OD1 1 
ATOM   125  O  OD2 . ASP   A 1 27  ? -43.642 -39.712  -16.388 1.00 87.67  ? 28   ASP   A OD2 1 
ATOM   126  N  N   . THR   A 1 28  ? -41.013 -44.172  -17.225 1.00 79.43  ? 29   THR   A N   1 
ATOM   127  C  CA  . THR   A 1 28  ? -40.334 -45.089  -18.179 1.00 77.70  ? 29   THR   A CA  1 
ATOM   128  C  C   . THR   A 1 28  ? -40.333 -46.508  -17.604 1.00 75.11  ? 29   THR   A C   1 
ATOM   129  O  O   . THR   A 1 28  ? -40.769 -47.431  -18.317 1.00 77.36  ? 29   THR   A O   1 
ATOM   130  C  CB  . THR   A 1 28  ? -38.914 -44.612  -18.499 1.00 80.09  ? 29   THR   A CB  1 
ATOM   131  O  OG1 . THR   A 1 28  ? -39.014 -43.341  -19.142 1.00 80.51  ? 29   THR   A OG1 1 
ATOM   132  C  CG2 . THR   A 1 28  ? -38.159 -45.576  -19.388 1.00 82.57  ? 29   THR   A CG2 1 
ATOM   133  N  N   . LEU   A 1 29  ? -39.872 -46.663  -16.361 1.00 73.37  ? 30   LEU   A N   1 
ATOM   134  C  CA  . LEU   A 1 29  ? -39.804 -47.974  -15.663 1.00 73.37  ? 30   LEU   A CA  1 
ATOM   135  C  C   . LEU   A 1 29  ? -41.219 -48.559  -15.563 1.00 70.87  ? 30   LEU   A C   1 
ATOM   136  O  O   . LEU   A 1 29  ? -41.381 -49.757  -15.861 1.00 68.61  ? 30   LEU   A O   1 
ATOM   137  C  CB  . LEU   A 1 29  ? -39.154 -47.786  -14.286 1.00 74.38  ? 30   LEU   A CB  1 
ATOM   138  C  CG  . LEU   A 1 29  ? -38.760 -49.068  -13.549 1.00 77.68  ? 30   LEU   A CG  1 
ATOM   139  C  CD1 . LEU   A 1 29  ? -37.947 -50.006  -14.434 1.00 78.09  ? 30   LEU   A CD1 1 
ATOM   140  C  CD2 . LEU   A 1 29  ? -37.989 -48.740  -12.280 1.00 77.35  ? 30   LEU   A CD2 1 
ATOM   141  N  N   . GLY   A 1 30  ? -42.204 -47.732  -15.196 1.00 74.49  ? 31   GLY   A N   1 
ATOM   142  C  CA  . GLY   A 1 30  ? -43.626 -48.115  -15.084 1.00 75.34  ? 31   GLY   A CA  1 
ATOM   143  C  C   . GLY   A 1 30  ? -44.189 -48.607  -16.408 1.00 76.32  ? 31   GLY   A C   1 
ATOM   144  O  O   . GLY   A 1 30  ? -44.771 -49.716  -16.434 1.00 78.70  ? 31   GLY   A O   1 
ATOM   145  N  N   . ALA   A 1 31  ? -44.029 -47.811  -17.470 1.00 74.42  ? 32   ALA   A N   1 
ATOM   146  C  CA  . ALA   A 1 31  ? -44.423 -48.157  -18.857 1.00 76.39  ? 32   ALA   A CA  1 
ATOM   147  C  C   . ALA   A 1 31  ? -43.807 -49.507  -19.235 1.00 79.61  ? 32   ALA   A C   1 
ATOM   148  O  O   . ALA   A 1 31  ? -44.547 -50.391  -19.703 1.00 83.51  ? 32   ALA   A O   1 
ATOM   149  C  CB  . ALA   A 1 31  ? -43.978 -47.071  -19.806 1.00 75.75  ? 32   ALA   A CB  1 
ATOM   150  N  N   . VAL   A 1 32  ? -42.495 -49.643  -19.012 1.00 82.43  ? 33   VAL   A N   1 
ATOM   151  C  CA  . VAL   A 1 32  ? -41.665 -50.835  -19.366 1.00 79.53  ? 33   VAL   A CA  1 
ATOM   152  C  C   . VAL   A 1 32  ? -42.137 -52.047  -18.550 1.00 79.23  ? 33   VAL   A C   1 
ATOM   153  O  O   . VAL   A 1 32  ? -42.328 -53.123  -19.152 1.00 79.08  ? 33   VAL   A O   1 
ATOM   154  C  CB  . VAL   A 1 32  ? -40.168 -50.527  -19.158 1.00 76.31  ? 33   VAL   A CB  1 
ATOM   155  C  CG1 . VAL   A 1 32  ? -39.325 -51.780  -18.991 1.00 75.69  ? 33   VAL   A CG1 1 
ATOM   156  C  CG2 . VAL   A 1 32  ? -39.625 -49.667  -20.289 1.00 74.53  ? 33   VAL   A CG2 1 
ATOM   157  N  N   . ALA   A 1 33  ? -42.316 -51.881  -17.237 1.00 80.02  ? 34   ALA   A N   1 
ATOM   158  C  CA  . ALA   A 1 33  ? -42.870 -52.911  -16.326 1.00 85.20  ? 34   ALA   A CA  1 
ATOM   159  C  C   . ALA   A 1 33  ? -44.253 -53.345  -16.829 1.00 86.90  ? 34   ALA   A C   1 
ATOM   160  O  O   . ALA   A 1 33  ? -44.506 -54.564  -16.895 1.00 80.44  ? 34   ALA   A O   1 
ATOM   161  C  CB  . ALA   A 1 33  ? -42.939 -52.374  -14.916 1.00 86.30  ? 34   ALA   A CB  1 
ATOM   162  N  N   . LYS   A 1 34  ? -45.098 -52.374  -17.195 1.00 92.16  ? 35   LYS   A N   1 
ATOM   163  C  CA  . LYS   A 1 34  ? -46.486 -52.598  -17.683 1.00 94.76  ? 35   LYS   A CA  1 
ATOM   164  C  C   . LYS   A 1 34  ? -46.458 -53.420  -18.979 1.00 91.96  ? 35   LYS   A C   1 
ATOM   165  O  O   . LYS   A 1 34  ? -47.393 -54.217  -19.184 1.00 94.18  ? 35   LYS   A O   1 
ATOM   166  C  CB  . LYS   A 1 34  ? -47.204 -51.257  -17.878 1.00 98.95  ? 35   LYS   A CB  1 
ATOM   167  C  CG  . LYS   A 1 34  ? -48.637 -51.349  -18.389 1.00 104.61 ? 35   LYS   A CG  1 
ATOM   168  C  CD  . LYS   A 1 34  ? -49.562 -52.149  -17.490 1.00 106.77 ? 35   LYS   A CD  1 
ATOM   169  C  CE  . LYS   A 1 34  ? -50.962 -52.285  -18.051 1.00 107.22 ? 35   LYS   A CE  1 
ATOM   170  N  NZ  . LYS   A 1 34  ? -51.912 -52.779  -17.026 1.00 107.12 ? 35   LYS   A NZ  1 
ATOM   171  N  N   . GLN   A 1 35  ? -45.429 -53.237  -19.816 1.00 90.76  ? 36   GLN   A N   1 
ATOM   172  C  CA  . GLN   A 1 35  ? -45.256 -53.964  -21.106 1.00 87.81  ? 36   GLN   A CA  1 
ATOM   173  C  C   . GLN   A 1 35  ? -44.847 -55.422  -20.841 1.00 83.12  ? 36   GLN   A C   1 
ATOM   174  O  O   . GLN   A 1 35  ? -45.035 -56.249  -21.747 1.00 77.29  ? 36   GLN   A O   1 
ATOM   175  C  CB  . GLN   A 1 35  ? -44.241 -53.245  -21.998 1.00 88.46  ? 36   GLN   A CB  1 
ATOM   176  C  CG  . GLN   A 1 35  ? -44.757 -51.931  -22.568 1.00 90.36  ? 36   GLN   A CG  1 
ATOM   177  C  CD  . GLN   A 1 35  ? -43.680 -51.104  -23.233 1.00 95.08  ? 36   GLN   A CD  1 
ATOM   178  O  OE1 . GLN   A 1 35  ? -42.501 -51.169  -22.884 1.00 95.70  ? 36   GLN   A OE1 1 
ATOM   179  N  NE2 . GLN   A 1 35  ? -44.080 -50.300  -24.206 1.00 97.35  ? 36   GLN   A NE2 1 
ATOM   180  N  N   . GLY   A 1 36  ? -44.296 -55.722  -19.658 1.00 86.15  ? 37   GLY   A N   1 
ATOM   181  C  CA  . GLY   A 1 36  ? -44.024 -57.098  -19.187 1.00 84.08  ? 37   GLY   A CA  1 
ATOM   182  C  C   . GLY   A 1 36  ? -42.540 -57.419  -19.052 1.00 80.76  ? 37   GLY   A C   1 
ATOM   183  O  O   . GLY   A 1 36  ? -42.220 -58.602  -18.843 1.00 79.87  ? 37   GLY   A O   1 
ATOM   184  N  N   . PHE   A 1 37  ? -41.658 -56.420  -19.148 1.00 77.38  ? 38   PHE   A N   1 
ATOM   185  C  CA  . PHE   A 1 37  ? -40.184 -56.595  -19.073 1.00 76.22  ? 38   PHE   A CA  1 
ATOM   186  C  C   . PHE   A 1 37  ? -39.752 -56.802  -17.616 1.00 77.75  ? 38   PHE   A C   1 
ATOM   187  O  O   . PHE   A 1 37  ? -40.332 -56.177  -16.708 1.00 81.86  ? 38   PHE   A O   1 
ATOM   188  C  CB  . PHE   A 1 37  ? -39.476 -55.403  -19.720 1.00 72.88  ? 38   PHE   A CB  1 
ATOM   189  C  CG  . PHE   A 1 37  ? -39.662 -55.333  -21.213 1.00 72.53  ? 38   PHE   A CG  1 
ATOM   190  C  CD1 . PHE   A 1 37  ? -38.988 -56.208  -22.050 1.00 72.50  ? 38   PHE   A CD1 1 
ATOM   191  C  CD2 . PHE   A 1 37  ? -40.527 -54.413  -21.783 1.00 74.50  ? 38   PHE   A CD2 1 
ATOM   192  C  CE1 . PHE   A 1 37  ? -39.163 -56.153  -23.424 1.00 71.95  ? 38   PHE   A CE1 1 
ATOM   193  C  CE2 . PHE   A 1 37  ? -40.698 -54.356  -23.158 1.00 73.90  ? 38   PHE   A CE2 1 
ATOM   194  C  CZ  . PHE   A 1 37  ? -40.017 -55.227  -23.975 1.00 72.30  ? 38   PHE   A CZ  1 
ATOM   195  N  N   . ASP   A 1 38  ? -38.749 -57.660  -17.411 1.00 77.37  ? 39   ASP   A N   1 
ATOM   196  C  CA  . ASP   A 1 38  ? -38.162 -57.976  -16.081 1.00 76.46  ? 39   ASP   A CA  1 
ATOM   197  C  C   . ASP   A 1 38  ? -37.218 -56.851  -15.642 1.00 72.03  ? 39   ASP   A C   1 
ATOM   198  O  O   . ASP   A 1 38  ? -37.039 -56.696  -14.419 1.00 73.91  ? 39   ASP   A O   1 
ATOM   199  C  CB  . ASP   A 1 38  ? -37.422 -59.314  -16.098 1.00 79.08  ? 39   ASP   A CB  1 
ATOM   200  C  CG  . ASP   A 1 38  ? -38.338 -60.523  -16.093 1.00 81.89  ? 39   ASP   A CG  1 
ATOM   201  O  OD1 . ASP   A 1 38  ? -39.533 -60.356  -16.400 1.00 84.25  ? 39   ASP   A OD1 1 
ATOM   202  O  OD2 . ASP   A 1 38  ? -37.845 -61.619  -15.773 1.00 90.30  ? 39   ASP   A OD2 1 
ATOM   203  N  N   . PHE   A 1 39  ? -36.627 -56.108  -16.587 1.00 66.69  ? 40   PHE   A N   1 
ATOM   204  C  CA  . PHE   A 1 39  ? -35.643 -55.029  -16.295 1.00 64.69  ? 40   PHE   A CA  1 
ATOM   205  C  C   . PHE   A 1 39  ? -35.513 -54.051  -17.469 1.00 62.71  ? 40   PHE   A C   1 
ATOM   206  O  O   . PHE   A 1 39  ? -36.043 -54.306  -18.563 1.00 61.92  ? 40   PHE   A O   1 
ATOM   207  C  CB  . PHE   A 1 39  ? -34.281 -55.636  -15.945 1.00 63.70  ? 40   PHE   A CB  1 
ATOM   208  C  CG  . PHE   A 1 39  ? -33.616 -56.427  -17.045 1.00 60.97  ? 40   PHE   A CG  1 
ATOM   209  C  CD1 . PHE   A 1 39  ? -33.902 -57.773  -17.228 1.00 59.34  ? 40   PHE   A CD1 1 
ATOM   210  C  CD2 . PHE   A 1 39  ? -32.676 -55.834  -17.876 1.00 59.04  ? 40   PHE   A CD2 1 
ATOM   211  C  CE1 . PHE   A 1 39  ? -33.277 -58.502  -18.232 1.00 59.86  ? 40   PHE   A CE1 1 
ATOM   212  C  CE2 . PHE   A 1 39  ? -32.051 -56.563  -18.877 1.00 57.84  ? 40   PHE   A CE2 1 
ATOM   213  C  CZ  . PHE   A 1 39  ? -32.354 -57.895  -19.056 1.00 58.36  ? 40   PHE   A CZ  1 
ATOM   214  N  N   . LEU   A 1 40  ? -34.795 -52.952  -17.227 1.00 64.38  ? 41   LEU   A N   1 
ATOM   215  C  CA  . LEU   A 1 40  ? -34.575 -51.836  -18.184 1.00 62.85  ? 41   LEU   A CA  1 
ATOM   216  C  C   . LEU   A 1 40  ? -33.073 -51.562  -18.311 1.00 61.73  ? 41   LEU   A C   1 
ATOM   217  O  O   . LEU   A 1 40  ? -32.432 -51.357  -17.268 1.00 65.38  ? 41   LEU   A O   1 
ATOM   218  C  CB  . LEU   A 1 40  ? -35.308 -50.596  -17.659 1.00 60.95  ? 41   LEU   A CB  1 
ATOM   219  C  CG  . LEU   A 1 40  ? -35.064 -49.303  -18.439 1.00 60.91  ? 41   LEU   A CG  1 
ATOM   220  C  CD1 . LEU   A 1 40  ? -35.507 -49.442  -19.883 1.00 60.58  ? 41   LEU   A CD1 1 
ATOM   221  C  CD2 . LEU   A 1 40  ? -35.770 -48.132  -17.782 1.00 62.17  ? 41   LEU   A CD2 1 
ATOM   222  N  N   . CYS   A 1 41  ? -32.543 -51.545  -19.539 1.00 60.36  ? 42   CYS   A N   1 
ATOM   223  C  CA  . CYS   A 1 41  ? -31.196 -51.005  -19.872 1.00 60.16  ? 42   CYS   A CA  1 
ATOM   224  C  C   . CYS   A 1 41  ? -31.349 -49.540  -20.290 1.00 61.06  ? 42   CYS   A C   1 
ATOM   225  O  O   . CYS   A 1 41  ? -32.103 -49.282  -21.243 1.00 65.16  ? 42   CYS   A O   1 
ATOM   226  C  CB  . CYS   A 1 41  ? -30.523 -51.790  -20.991 1.00 59.68  ? 42   CYS   A CB  1 
ATOM   227  S  SG  . CYS   A 1 41  ? -30.692 -53.585  -20.823 1.00 60.02  ? 42   CYS   A SG  1 
ATOM   228  N  N   . MET   A 1 42  ? -30.676 -48.618  -19.601 1.00 63.43  ? 43   MET   A N   1 
ATOM   229  C  CA  . MET   A 1 42  ? -30.841 -47.156  -19.819 1.00 66.38  ? 43   MET   A CA  1 
ATOM   230  C  C   . MET   A 1 42  ? -29.557 -46.425  -19.446 1.00 64.99  ? 43   MET   A C   1 
ATOM   231  O  O   . MET   A 1 42  ? -28.751 -46.929  -18.670 1.00 66.87  ? 43   MET   A O   1 
ATOM   232  C  CB  . MET   A 1 42  ? -31.997 -46.605  -18.978 1.00 69.25  ? 43   MET   A CB  1 
ATOM   233  C  CG  . MET   A 1 42  ? -32.039 -47.168  -17.571 1.00 72.61  ? 43   MET   A CG  1 
ATOM   234  S  SD  . MET   A 1 42  ? -33.077 -46.192  -16.458 1.00 77.15  ? 43   MET   A SD  1 
ATOM   235  C  CE  . MET   A 1 42  ? -32.026 -44.761  -16.214 1.00 77.90  ? 43   MET   A CE  1 
ATOM   236  N  N   . PRO   A 1 43  ? -29.326 -45.211  -19.992 1.00 66.29  ? 44   PRO   A N   1 
ATOM   237  C  CA  . PRO   A 1 43  ? -28.195 -44.387  -19.574 1.00 67.99  ? 44   PRO   A CA  1 
ATOM   238  C  C   . PRO   A 1 43  ? -28.344 -43.991  -18.099 1.00 67.51  ? 44   PRO   A C   1 
ATOM   239  O  O   . PRO   A 1 43  ? -29.461 -43.919  -17.621 1.00 69.82  ? 44   PRO   A O   1 
ATOM   240  C  CB  . PRO   A 1 43  ? -28.256 -43.143  -20.475 1.00 66.10  ? 44   PRO   A CB  1 
ATOM   241  C  CG  . PRO   A 1 43  ? -29.187 -43.525  -21.606 1.00 66.43  ? 44   PRO   A CG  1 
ATOM   242  C  CD  . PRO   A 1 43  ? -30.130 -44.565  -21.040 1.00 65.75  ? 44   PRO   A CD  1 
ATOM   243  N  N   . VAL   A 1 44  ? -27.218 -43.759  -17.425 1.00 63.93  ? 45   VAL   A N   1 
ATOM   244  C  CA  . VAL   A 1 44  ? -27.164 -43.270  -16.015 1.00 63.70  ? 45   VAL   A CA  1 
ATOM   245  C  C   . VAL   A 1 44  ? -26.740 -41.796  -16.031 1.00 63.09  ? 45   VAL   A C   1 
ATOM   246  O  O   . VAL   A 1 44  ? -26.993 -41.101  -15.031 1.00 66.05  ? 45   VAL   A O   1 
ATOM   247  C  CB  . VAL   A 1 44  ? -26.247 -44.155  -15.146 1.00 65.26  ? 45   VAL   A CB  1 
ATOM   248  C  CG1 . VAL   A 1 44  ? -26.925 -45.471  -14.796 1.00 65.34  ? 45   VAL   A CG1 1 
ATOM   249  C  CG2 . VAL   A 1 44  ? -24.892 -44.416  -15.790 1.00 65.41  ? 45   VAL   A CG2 1 
ATOM   250  N  N   . PHE   A 1 45  ? -26.104 -41.362  -17.124 1.00 62.80  ? 46   PHE   A N   1 
ATOM   251  C  CA  . PHE   A 1 45  ? -25.902 -39.948  -17.540 1.00 63.15  ? 46   PHE   A CA  1 
ATOM   252  C  C   . PHE   A 1 45  ? -26.556 -39.780  -18.915 1.00 63.43  ? 46   PHE   A C   1 
ATOM   253  O  O   . PHE   A 1 45  ? -26.681 -40.797  -19.622 1.00 64.84  ? 46   PHE   A O   1 
ATOM   254  C  CB  . PHE   A 1 45  ? -24.410 -39.602  -17.599 1.00 61.35  ? 46   PHE   A CB  1 
ATOM   255  C  CG  . PHE   A 1 45  ? -23.713 -39.549  -16.261 1.00 60.80  ? 46   PHE   A CG  1 
ATOM   256  C  CD1 . PHE   A 1 45  ? -23.629 -40.676  -15.455 1.00 60.04  ? 46   PHE   A CD1 1 
ATOM   257  C  CD2 . PHE   A 1 45  ? -23.126 -38.375  -15.810 1.00 60.71  ? 46   PHE   A CD2 1 
ATOM   258  C  CE1 . PHE   A 1 45  ? -22.986 -40.628  -14.228 1.00 60.74  ? 46   PHE   A CE1 1 
ATOM   259  C  CE2 . PHE   A 1 45  ? -22.481 -38.328  -14.582 1.00 61.31  ? 46   PHE   A CE2 1 
ATOM   260  C  CZ  . PHE   A 1 45  ? -22.415 -39.453  -13.792 1.00 61.66  ? 46   PHE   A CZ  1 
ATOM   261  N  N   . HIS   A 1 46  ? -26.966 -38.565  -19.288 1.00 64.19  ? 47   HIS   A N   1 
ATOM   262  C  CA  . HIS   A 1 46  ? -27.641 -38.302  -20.589 1.00 65.53  ? 47   HIS   A CA  1 
ATOM   263  C  C   . HIS   A 1 46  ? -26.666 -38.589  -21.731 1.00 59.77  ? 47   HIS   A C   1 
ATOM   264  O  O   . HIS   A 1 46  ? -25.580 -38.016  -21.780 1.00 61.35  ? 47   HIS   A O   1 
ATOM   265  C  CB  . HIS   A 1 46  ? -28.215 -36.879  -20.667 1.00 70.74  ? 47   HIS   A CB  1 
ATOM   266  C  CG  . HIS   A 1 46  ? -29.108 -36.668  -21.846 1.00 73.09  ? 47   HIS   A CG  1 
ATOM   267  N  ND1 . HIS   A 1 46  ? -28.619 -36.552  -23.134 1.00 74.35  ? 47   HIS   A ND1 1 
ATOM   268  C  CD2 . HIS   A 1 46  ? -30.452 -36.573  -21.943 1.00 74.28  ? 47   HIS   A CD2 1 
ATOM   269  C  CE1 . HIS   A 1 46  ? -29.623 -36.389  -23.971 1.00 76.80  ? 47   HIS   A CE1 1 
ATOM   270  N  NE2 . HIS   A 1 46  ? -30.758 -36.392  -23.265 1.00 77.17  ? 47   HIS   A NE2 1 
ATOM   271  N  N   . PRO   A 1 47  ? -27.040 -39.456  -22.700 1.00 54.49  ? 48   PRO   A N   1 
ATOM   272  C  CA  . PRO   A 1 47  ? -26.119 -39.911  -23.741 1.00 55.33  ? 48   PRO   A CA  1 
ATOM   273  C  C   . PRO   A 1 47  ? -25.384 -38.814  -24.522 1.00 59.11  ? 48   PRO   A C   1 
ATOM   274  O  O   . PRO   A 1 47  ? -24.325 -39.102  -25.032 1.00 60.24  ? 48   PRO   A O   1 
ATOM   275  C  CB  . PRO   A 1 47  ? -27.034 -40.642  -24.727 1.00 54.09  ? 48   PRO   A CB  1 
ATOM   276  C  CG  . PRO   A 1 47  ? -28.172 -41.134  -23.876 1.00 53.11  ? 48   PRO   A CG  1 
ATOM   277  C  CD  . PRO   A 1 47  ? -28.379 -40.044  -22.848 1.00 53.12  ? 48   PRO   A CD  1 
ATOM   278  N  N   . ARG   A 1 48  ? -25.967 -37.613  -24.611 1.00 62.52  ? 49   ARG   A N   1 
ATOM   279  C  CA  . ARG   A 1 48  ? -25.430 -36.473  -25.405 1.00 62.33  ? 49   ARG   A CA  1 
ATOM   280  C  C   . ARG   A 1 48  ? -24.674 -35.488  -24.506 1.00 60.00  ? 49   ARG   A C   1 
ATOM   281  O  O   . ARG   A 1 48  ? -24.136 -34.512  -25.054 1.00 59.45  ? 49   ARG   A O   1 
ATOM   282  C  CB  . ARG   A 1 48  ? -26.565 -35.770  -26.158 1.00 60.91  ? 49   ARG   A CB  1 
ATOM   283  C  CG  . ARG   A 1 48  ? -27.096 -36.577  -27.333 1.00 62.70  ? 49   ARG   A CG  1 
ATOM   284  C  CD  . ARG   A 1 48  ? -27.981 -35.771  -28.263 1.00 62.69  ? 49   ARG   A CD  1 
ATOM   285  N  NE  . ARG   A 1 48  ? -29.244 -35.428  -27.622 1.00 61.90  ? 49   ARG   A NE  1 
ATOM   286  C  CZ  . ARG   A 1 48  ? -29.602 -34.219  -27.196 1.00 58.73  ? 49   ARG   A CZ  1 
ATOM   287  N  NH1 . ARG   A 1 48  ? -30.780 -34.057  -26.616 1.00 56.23  ? 49   ARG   A NH1 1 
ATOM   288  N  NH2 . ARG   A 1 48  ? -28.801 -33.176  -27.342 1.00 59.97  ? 49   ARG   A NH2 1 
ATOM   289  N  N   . PHE   A 1 49  ? -24.607 -35.738  -23.194 1.00 59.86  ? 50   PHE   A N   1 
ATOM   290  C  CA  . PHE   A 1 49  ? -24.011 -34.807  -22.199 1.00 62.09  ? 50   PHE   A CA  1 
ATOM   291  C  C   . PHE   A 1 49  ? -22.497 -35.039  -22.102 1.00 61.03  ? 50   PHE   A C   1 
ATOM   292  O  O   . PHE   A 1 49  ? -22.030 -35.477  -21.039 1.00 60.07  ? 50   PHE   A O   1 
ATOM   293  C  CB  . PHE   A 1 49  ? -24.717 -34.966  -20.847 1.00 62.60  ? 50   PHE   A CB  1 
ATOM   294  C  CG  . PHE   A 1 49  ? -24.489 -33.851  -19.855 1.00 63.91  ? 50   PHE   A CG  1 
ATOM   295  C  CD1 . PHE   A 1 49  ? -24.392 -32.527  -20.265 1.00 68.14  ? 50   PHE   A CD1 1 
ATOM   296  C  CD2 . PHE   A 1 49  ? -24.417 -34.121  -18.497 1.00 63.49  ? 50   PHE   A CD2 1 
ATOM   297  C  CE1 . PHE   A 1 49  ? -24.206 -31.507  -19.343 1.00 67.85  ? 50   PHE   A CE1 1 
ATOM   298  C  CE2 . PHE   A 1 49  ? -24.230 -33.099  -17.578 1.00 64.46  ? 50   PHE   A CE2 1 
ATOM   299  C  CZ  . PHE   A 1 49  ? -24.124 -31.794  -18.001 1.00 65.42  ? 50   PHE   A CZ  1 
ATOM   300  N  N   . LYS   A 1 50  ? -21.755 -34.754  -23.179 1.00 60.38  ? 51   LYS   A N   1 
ATOM   301  C  CA  . LYS   A 1 50  ? -20.266 -34.765  -23.181 1.00 63.09  ? 51   LYS   A CA  1 
ATOM   302  C  C   . LYS   A 1 50  ? -19.781 -33.882  -22.029 1.00 61.84  ? 51   LYS   A C   1 
ATOM   303  O  O   . LYS   A 1 50  ? -20.368 -32.798  -21.844 1.00 60.99  ? 51   LYS   A O   1 
ATOM   304  C  CB  . LYS   A 1 50  ? -19.687 -34.236  -24.497 1.00 67.66  ? 51   LYS   A CB  1 
ATOM   305  C  CG  . LYS   A 1 50  ? -19.288 -35.274  -25.539 1.00 72.41  ? 51   LYS   A CG  1 
ATOM   306  C  CD  . LYS   A 1 50  ? -18.204 -34.758  -26.474 1.00 76.12  ? 51   LYS   A CD  1 
ATOM   307  C  CE  . LYS   A 1 50  ? -18.053 -35.542  -27.760 1.00 80.24  ? 51   LYS   A CE  1 
ATOM   308  N  NZ  . LYS   A 1 50  ? -19.222 -35.382  -28.656 1.00 82.28  ? 51   LYS   A NZ  1 
ATOM   309  N  N   . ARG   A 1 51  ? -18.761 -34.330  -21.290 1.00 60.17  ? 52   ARG   A N   1 
ATOM   310  C  CA  . ARG   A 1 51  ? -18.205 -33.617  -20.109 1.00 60.13  ? 52   ARG   A CA  1 
ATOM   311  C  C   . ARG   A 1 51  ? -16.694 -33.443  -20.289 1.00 61.67  ? 52   ARG   A C   1 
ATOM   312  O  O   . ARG   A 1 51  ? -16.046 -34.347  -20.857 1.00 64.05  ? 52   ARG   A O   1 
ATOM   313  C  CB  . ARG   A 1 51  ? -18.560 -34.371  -18.824 1.00 58.72  ? 52   ARG   A CB  1 
ATOM   314  C  CG  . ARG   A 1 51  ? -20.039 -34.716  -18.724 1.00 60.69  ? 52   ARG   A CG  1 
ATOM   315  C  CD  . ARG   A 1 51  ? -20.468 -35.370  -17.423 1.00 61.65  ? 52   ARG   A CD  1 
ATOM   316  N  NE  . ARG   A 1 51  ? -20.217 -36.806  -17.391 1.00 61.81  ? 52   ARG   A NE  1 
ATOM   317  C  CZ  . ARG   A 1 51  ? -20.895 -37.727  -18.075 1.00 61.45  ? 52   ARG   A CZ  1 
ATOM   318  N  NH1 . ARG   A 1 51  ? -20.577 -39.006  -17.950 1.00 61.11  ? 52   ARG   A NH1 1 
ATOM   319  N  NH2 . ARG   A 1 51  ? -21.886 -37.381  -18.878 1.00 64.61  ? 52   ARG   A NH2 1 
ATOM   320  N  N   . GLU   A 1 52  ? -16.171 -32.298  -19.847 1.00 62.02  ? 53   GLU   A N   1 
ATOM   321  C  CA  . GLU   A 1 52  ? -14.724 -31.968  -19.860 1.00 63.59  ? 53   GLU   A CA  1 
ATOM   322  C  C   . GLU   A 1 52  ? -14.190 -32.131  -18.431 1.00 64.51  ? 53   GLU   A C   1 
ATOM   323  O  O   . GLU   A 1 52  ? -14.893 -31.714  -17.484 1.00 62.05  ? 53   GLU   A O   1 
ATOM   324  C  CB  . GLU   A 1 52  ? -14.507 -30.556  -20.410 1.00 62.88  ? 53   GLU   A CB  1 
ATOM   325  C  CG  . GLU   A 1 52  ? -13.046 -30.141  -20.487 1.00 65.30  ? 53   GLU   A CG  1 
ATOM   326  C  CD  . GLU   A 1 52  ? -12.166 -31.035  -21.346 1.00 68.66  ? 53   GLU   A CD  1 
ATOM   327  O  OE1 . GLU   A 1 52  ? -12.629 -31.446  -22.432 1.00 66.48  ? 53   GLU   A OE1 1 
ATOM   328  O  OE2 . GLU   A 1 52  ? -11.019 -31.320  -20.929 1.00 71.38  ? 53   GLU   A OE2 1 
ATOM   329  N  N   . PHE   A 1 53  ? -13.002 -32.730  -18.291 1.00 62.70  ? 54   PHE   A N   1 
ATOM   330  C  CA  . PHE   A 1 53  ? -12.359 -33.051  -16.990 1.00 61.33  ? 54   PHE   A CA  1 
ATOM   331  C  C   . PHE   A 1 53  ? -11.051 -32.267  -16.815 1.00 68.11  ? 54   PHE   A C   1 
ATOM   332  O  O   . PHE   A 1 53  ? -10.570 -32.197  -15.665 1.00 73.92  ? 54   PHE   A O   1 
ATOM   333  C  CB  . PHE   A 1 53  ? -12.134 -34.562  -16.885 1.00 57.33  ? 54   PHE   A CB  1 
ATOM   334  C  CG  . PHE   A 1 53  ? -13.399 -35.383  -16.837 1.00 53.51  ? 54   PHE   A CG  1 
ATOM   335  C  CD1 . PHE   A 1 53  ? -14.054 -35.753  -18.004 1.00 50.92  ? 54   PHE   A CD1 1 
ATOM   336  C  CD2 . PHE   A 1 53  ? -13.941 -35.783  -15.624 1.00 50.73  ? 54   PHE   A CD2 1 
ATOM   337  C  CE1 . PHE   A 1 53  ? -15.220 -36.503  -17.959 1.00 48.57  ? 54   PHE   A CE1 1 
ATOM   338  C  CE2 . PHE   A 1 53  ? -15.105 -36.537  -15.580 1.00 49.55  ? 54   PHE   A CE2 1 
ATOM   339  C  CZ  . PHE   A 1 53  ? -15.742 -36.895  -16.748 1.00 48.71  ? 54   PHE   A CZ  1 
ATOM   340  N  N   . ILE   A 1 54  ? -10.502 -31.682  -17.887 1.00 74.86  ? 55   ILE   A N   1 
ATOM   341  C  CA  . ILE   A 1 54  ? -9.173  -30.998  -17.863 1.00 82.17  ? 55   ILE   A CA  1 
ATOM   342  C  C   . ILE   A 1 54  ? -9.347  -29.504  -18.187 1.00 86.75  ? 55   ILE   A C   1 
ATOM   343  O  O   . ILE   A 1 54  ? -9.090  -28.682  -17.282 1.00 86.71  ? 55   ILE   A O   1 
ATOM   344  C  CB  . ILE   A 1 54  ? -8.173  -31.700  -18.809 1.00 83.99  ? 55   ILE   A CB  1 
ATOM   345  C  CG1 . ILE   A 1 54  ? -8.018  -33.188  -18.474 1.00 86.41  ? 55   ILE   A CG1 1 
ATOM   346  C  CG2 . ILE   A 1 54  ? -6.830  -30.987  -18.806 1.00 84.31  ? 55   ILE   A CG2 1 
ATOM   347  C  CD1 . ILE   A 1 54  ? -8.855  -34.113  -19.332 1.00 87.99  ? 55   ILE   A CD1 1 
ATOM   348  N  N   . GLN   A 1 55  ? -9.773  -29.165  -19.412 1.00 89.08  ? 56   GLN   A N   1 
ATOM   349  C  CA  . GLN   A 1 55  ? -9.666  -27.791  -19.986 1.00 90.30  ? 56   GLN   A CA  1 
ATOM   350  C  C   . GLN   A 1 55  ? -10.792 -26.887  -19.467 1.00 89.21  ? 56   GLN   A C   1 
ATOM   351  O  O   . GLN   A 1 55  ? -11.976 -27.263  -19.597 1.00 84.71  ? 56   GLN   A O   1 
ATOM   352  C  CB  . GLN   A 1 55  ? -9.685  -27.826  -21.517 1.00 89.92  ? 56   GLN   A CB  1 
ATOM   353  C  CG  . GLN   A 1 55  ? -8.978  -26.634  -22.150 1.00 92.62  ? 56   GLN   A CG  1 
ATOM   354  C  CD  . GLN   A 1 55  ? -9.053  -26.621  -23.660 1.00 98.96  ? 56   GLN   A CD  1 
ATOM   355  O  OE1 . GLN   A 1 55  ? -9.433  -27.601  -24.299 1.00 101.98 ? 56   GLN   A OE1 1 
ATOM   356  N  NE2 . GLN   A 1 55  ? -8.682  -25.497  -24.250 1.00 102.47 ? 56   GLN   A NE2 1 
ATOM   357  N  N   . GLU   A 1 56  ? -10.421 -25.718  -18.931 1.00 90.48  ? 57   GLU   A N   1 
ATOM   358  C  CA  . GLU   A 1 56  ? -11.355 -24.628  -18.535 1.00 90.03  ? 57   GLU   A CA  1 
ATOM   359  C  C   . GLU   A 1 56  ? -11.770 -23.898  -19.811 1.00 87.35  ? 57   GLU   A C   1 
ATOM   360  O  O   . GLU   A 1 56  ? -10.988 -23.825  -20.756 1.00 88.24  ? 57   GLU   A O   1 
ATOM   361  C  CB  . GLU   A 1 56  ? -10.694 -23.686  -17.523 1.00 92.01  ? 57   GLU   A CB  1 
ATOM   362  C  CG  . GLU   A 1 56  ? -9.867  -24.407  -16.468 1.00 100.35 ? 57   GLU   A CG  1 
ATOM   363  C  CD  . GLU   A 1 56  ? -9.792  -23.736  -15.107 1.00 106.28 ? 57   GLU   A CD  1 
ATOM   364  O  OE1 . GLU   A 1 56  ? -10.280 -24.337  -14.125 1.00 108.42 ? 57   GLU   A OE1 1 
ATOM   365  O  OE2 . GLU   A 1 56  ? -9.232  -22.623  -15.025 1.00 111.07 ? 57   GLU   A OE2 1 
ATOM   366  N  N   . PRO   A 1 57  ? -12.994 -23.333  -19.907 1.00 81.44  ? 58   PRO   A N   1 
ATOM   367  C  CA  . PRO   A 1 57  ? -13.963 -23.312  -18.808 1.00 81.45  ? 58   PRO   A CA  1 
ATOM   368  C  C   . PRO   A 1 57  ? -14.916 -24.516  -18.706 1.00 78.32  ? 58   PRO   A C   1 
ATOM   369  O  O   . PRO   A 1 57  ? -15.516 -24.678  -17.655 1.00 74.84  ? 58   PRO   A O   1 
ATOM   370  C  CB  . PRO   A 1 57  ? -14.765 -22.049  -19.150 1.00 83.09  ? 58   PRO   A CB  1 
ATOM   371  C  CG  . PRO   A 1 57  ? -14.818 -22.055  -20.664 1.00 84.52  ? 58   PRO   A CG  1 
ATOM   372  C  CD  . PRO   A 1 57  ? -13.487 -22.631  -21.100 1.00 83.09  ? 58   PRO   A CD  1 
ATOM   373  N  N   . ALA   A 1 58  ? -15.033 -25.324  -19.768 1.00 79.32  ? 59   ALA   A N   1 
ATOM   374  C  CA  . ALA   A 1 58  ? -15.939 -26.500  -19.862 1.00 79.68  ? 59   ALA   A CA  1 
ATOM   375  C  C   . ALA   A 1 58  ? -15.813 -27.396  -18.618 1.00 76.34  ? 59   ALA   A C   1 
ATOM   376  O  O   . ALA   A 1 58  ? -16.844 -27.951  -18.177 1.00 68.56  ? 59   ALA   A O   1 
ATOM   377  C  CB  . ALA   A 1 58  ? -15.643 -27.275  -21.125 1.00 79.62  ? 59   ALA   A CB  1 
ATOM   378  N  N   . LYS   A 1 59  ? -14.595 -27.541  -18.083 1.00 77.53  ? 60   LYS   A N   1 
ATOM   379  C  CA  . LYS   A 1 59  ? -14.279 -28.360  -16.880 1.00 80.92  ? 60   LYS   A CA  1 
ATOM   380  C  C   . LYS   A 1 59  ? -15.242 -28.022  -15.735 1.00 80.15  ? 60   LYS   A C   1 
ATOM   381  O  O   . LYS   A 1 59  ? -15.744 -28.968  -15.091 1.00 78.32  ? 60   LYS   A O   1 
ATOM   382  C  CB  . LYS   A 1 59  ? -12.835 -28.127  -16.419 1.00 83.62  ? 60   LYS   A CB  1 
ATOM   383  C  CG  . LYS   A 1 59  ? -12.384 -29.019  -15.270 1.00 87.02  ? 60   LYS   A CG  1 
ATOM   384  C  CD  . LYS   A 1 59  ? -11.177 -28.518  -14.510 1.00 91.10  ? 60   LYS   A CD  1 
ATOM   385  C  CE  . LYS   A 1 59  ? -11.070 -29.149  -13.137 1.00 92.87  ? 60   LYS   A CE  1 
ATOM   386  N  NZ  . LYS   A 1 59  ? -9.829  -28.744  -12.439 1.00 97.60  ? 60   LYS   A NZ  1 
ATOM   387  N  N   . ASN   A 1 60  ? -15.485 -26.727  -15.495 1.00 78.32  ? 61   ASN   A N   1 
ATOM   388  C  CA  . ASN   A 1 60  ? -16.177 -26.215  -14.280 1.00 76.76  ? 61   ASN   A CA  1 
ATOM   389  C  C   . ASN   A 1 60  ? -17.681 -26.064  -14.542 1.00 72.36  ? 61   ASN   A C   1 
ATOM   390  O  O   . ASN   A 1 60  ? -18.344 -25.371  -13.744 1.00 67.75  ? 61   ASN   A O   1 
ATOM   391  C  CB  . ASN   A 1 60  ? -15.541 -24.911  -13.794 1.00 77.74  ? 61   ASN   A CB  1 
ATOM   392  C  CG  . ASN   A 1 60  ? -14.061 -25.067  -13.508 1.00 82.46  ? 61   ASN   A CG  1 
ATOM   393  O  OD1 . ASN   A 1 60  ? -13.654 -26.022  -12.848 1.00 80.79  ? 61   ASN   A OD1 1 
ATOM   394  N  ND2 . ASN   A 1 60  ? -13.247 -24.151  -14.008 1.00 86.19  ? 61   ASN   A ND2 1 
ATOM   395  N  N   . ARG   A 1 61  ? -18.212 -26.709  -15.587 1.00 69.64  ? 62   ARG   A N   1 
ATOM   396  C  CA  . ARG   A 1 61  ? -19.672 -26.737  -15.855 1.00 70.72  ? 62   ARG   A CA  1 
ATOM   397  C  C   . ARG   A 1 61  ? -20.391 -26.949  -14.527 1.00 72.80  ? 62   ARG   A C   1 
ATOM   398  O  O   . ARG   A 1 61  ? -20.210 -27.982  -13.887 1.00 72.75  ? 62   ARG   A O   1 
ATOM   399  C  CB  . ARG   A 1 61  ? -20.054 -27.839  -16.849 1.00 69.97  ? 62   ARG   A CB  1 
ATOM   400  C  CG  . ARG   A 1 61  ? -21.559 -28.030  -17.003 1.00 69.59  ? 62   ARG   A CG  1 
ATOM   401  C  CD  . ARG   A 1 61  ? -21.917 -29.157  -17.950 1.00 70.63  ? 62   ARG   A CD  1 
ATOM   402  N  NE  . ARG   A 1 61  ? -21.223 -29.002  -19.220 1.00 70.66  ? 62   ARG   A NE  1 
ATOM   403  C  CZ  . ARG   A 1 61  ? -20.920 -29.986  -20.057 1.00 71.11  ? 62   ARG   A CZ  1 
ATOM   404  N  NH1 . ARG   A 1 61  ? -21.248 -31.236  -19.778 1.00 70.42  ? 62   ARG   A NH1 1 
ATOM   405  N  NH2 . ARG   A 1 61  ? -20.280 -29.710  -21.180 1.00 74.29  ? 62   ARG   A NH2 1 
ATOM   406  N  N   . PRO   A 1 62  ? -21.222 -25.985  -14.072 1.00 77.12  ? 63   PRO   A N   1 
ATOM   407  C  CA  . PRO   A 1 62  ? -21.949 -26.130  -12.810 1.00 74.74  ? 63   PRO   A CA  1 
ATOM   408  C  C   . PRO   A 1 62  ? -23.022 -27.227  -12.846 1.00 72.76  ? 63   PRO   A C   1 
ATOM   409  O  O   . PRO   A 1 62  ? -23.070 -27.978  -13.802 1.00 68.61  ? 63   PRO   A O   1 
ATOM   410  C  CB  . PRO   A 1 62  ? -22.617 -24.755  -12.636 1.00 78.12  ? 63   PRO   A CB  1 
ATOM   411  C  CG  . PRO   A 1 62  ? -22.777 -24.240  -14.049 1.00 77.57  ? 63   PRO   A CG  1 
ATOM   412  C  CD  . PRO   A 1 62  ? -21.525 -24.714  -14.754 1.00 78.08  ? 63   PRO   A CD  1 
ATOM   413  N  N   . GLY   A 1 63  ? -23.840 -27.287  -11.791 1.00 77.38  ? 64   GLY   A N   1 
ATOM   414  C  CA  . GLY   A 1 63  ? -25.102 -28.051  -11.738 1.00 74.88  ? 64   GLY   A CA  1 
ATOM   415  C  C   . GLY   A 1 63  ? -24.859 -29.544  -11.555 1.00 71.48  ? 64   GLY   A C   1 
ATOM   416  O  O   . GLY   A 1 63  ? -23.726 -30.008  -11.650 1.00 69.27  ? 64   GLY   A O   1 
ATOM   417  N  N   . PRO   A 1 64  ? -25.921 -30.336  -11.286 1.00 69.95  ? 65   PRO   A N   1 
ATOM   418  C  CA  . PRO   A 1 64  ? -25.792 -31.787  -11.144 1.00 68.39  ? 65   PRO   A CA  1 
ATOM   419  C  C   . PRO   A 1 64  ? -25.330 -32.479  -12.436 1.00 67.69  ? 65   PRO   A C   1 
ATOM   420  O  O   . PRO   A 1 64  ? -25.854 -32.163  -13.488 1.00 70.54  ? 65   PRO   A O   1 
ATOM   421  C  CB  . PRO   A 1 64  ? -27.212 -32.237  -10.778 1.00 68.52  ? 65   PRO   A CB  1 
ATOM   422  C  CG  . PRO   A 1 64  ? -28.103 -31.144  -11.325 1.00 68.84  ? 65   PRO   A CG  1 
ATOM   423  C  CD  . PRO   A 1 64  ? -27.307 -29.874  -11.116 1.00 69.07  ? 65   PRO   A CD  1 
ATOM   424  N  N   . GLN   A 1 65  ? -24.373 -33.403  -12.321 1.00 66.68  ? 66   GLN   A N   1 
ATOM   425  C  CA  . GLN   A 1 65  ? -23.766 -34.134  -13.467 1.00 65.20  ? 66   GLN   A CA  1 
ATOM   426  C  C   . GLN   A 1 65  ? -24.764 -35.163  -14.014 1.00 64.44  ? 66   GLN   A C   1 
ATOM   427  O  O   . GLN   A 1 65  ? -24.627 -35.540  -15.193 1.00 66.79  ? 66   GLN   A O   1 
ATOM   428  C  CB  . GLN   A 1 65  ? -22.452 -34.793  -13.043 1.00 65.38  ? 66   GLN   A CB  1 
ATOM   429  C  CG  . GLN   A 1 65  ? -21.372 -33.799  -12.639 1.00 67.18  ? 66   GLN   A CG  1 
ATOM   430  C  CD  . GLN   A 1 65  ? -21.067 -32.801  -13.730 1.00 69.73  ? 66   GLN   A CD  1 
ATOM   431  O  OE1 . GLN   A 1 65  ? -20.938 -33.148  -14.902 1.00 74.93  ? 66   GLN   A OE1 1 
ATOM   432  N  NE2 . GLN   A 1 65  ? -20.949 -31.540  -13.351 1.00 69.69  ? 66   GLN   A NE2 1 
ATOM   433  N  N   . THR   A 1 66  ? -25.729 -35.602  -13.199 1.00 60.69  ? 67   THR   A N   1 
ATOM   434  C  CA  . THR   A 1 66  ? -26.847 -36.479  -13.636 1.00 59.08  ? 67   THR   A CA  1 
ATOM   435  C  C   . THR   A 1 66  ? -28.004 -36.387  -12.638 1.00 59.15  ? 67   THR   A C   1 
ATOM   436  O  O   . THR   A 1 66  ? -27.970 -35.494  -11.778 1.00 60.09  ? 67   THR   A O   1 
ATOM   437  C  CB  . THR   A 1 66  ? -26.373 -37.925  -13.817 1.00 60.94  ? 67   THR   A CB  1 
ATOM   438  O  OG1 . THR   A 1 66  ? -27.447 -38.656  -14.413 1.00 58.65  ? 67   THR   A OG1 1 
ATOM   439  C  CG2 . THR   A 1 66  ? -25.961 -38.583  -12.518 1.00 63.45  ? 67   THR   A CG2 1 
ATOM   440  N  N   . ARG   A 1 67  ? -28.979 -37.291  -12.759 1.00 61.57  ? 68   ARG   A N   1 
ATOM   441  C  CA  . ARG   A 1 67  ? -30.189 -37.349  -11.899 1.00 67.63  ? 68   ARG   A CA  1 
ATOM   442  C  C   . ARG   A 1 67  ? -29.887 -38.136  -10.616 1.00 72.16  ? 68   ARG   A C   1 
ATOM   443  O  O   . ARG   A 1 67  ? -28.980 -39.001  -10.631 1.00 73.58  ? 68   ARG   A O   1 
ATOM   444  C  CB  . ARG   A 1 67  ? -31.376 -37.949  -12.661 1.00 71.58  ? 68   ARG   A CB  1 
ATOM   445  C  CG  . ARG   A 1 67  ? -31.066 -39.217  -13.441 1.00 74.23  ? 68   ARG   A CG  1 
ATOM   446  C  CD  . ARG   A 1 67  ? -32.322 -39.944  -13.871 1.00 75.76  ? 68   ARG   A CD  1 
ATOM   447  N  NE  . ARG   A 1 67  ? -33.129 -39.186  -14.823 1.00 78.96  ? 68   ARG   A NE  1 
ATOM   448  C  CZ  . ARG   A 1 67  ? -33.386 -39.539  -16.087 1.00 80.38  ? 68   ARG   A CZ  1 
ATOM   449  N  NH1 . ARG   A 1 67  ? -34.141 -38.758  -16.842 1.00 77.21  ? 68   ARG   A NH1 1 
ATOM   450  N  NH2 . ARG   A 1 67  ? -32.905 -40.662  -16.600 1.00 83.64  ? 68   ARG   A NH2 1 
ATOM   451  N  N   . SER   A 1 68  ? -30.651 -37.844  -9.557  1.00 73.53  ? 69   SER   A N   1 
ATOM   452  C  CA  . SER   A 1 68  ? -30.443 -38.324  -8.167  1.00 70.93  ? 69   SER   A CA  1 
ATOM   453  C  C   . SER   A 1 68  ? -30.773 -39.815  -8.055  1.00 68.45  ? 69   SER   A C   1 
ATOM   454  O  O   . SER   A 1 68  ? -31.648 -40.287  -8.803  1.00 64.63  ? 69   SER   A O   1 
ATOM   455  C  CB  . SER   A 1 68  ? -31.267 -37.520  -7.195  1.00 71.35  ? 69   SER   A CB  1 
ATOM   456  O  OG  . SER   A 1 68  ? -30.942 -37.860  -5.855  1.00 70.69  ? 69   SER   A OG  1 
ATOM   457  N  N   . ASP   A 1 69  ? -30.091 -40.505  -7.133  1.00 68.96  ? 70   ASP   A N   1 
ATOM   458  C  CA  . ASP   A 1 69  ? -30.351 -41.918  -6.744  1.00 67.99  ? 70   ASP   A CA  1 
ATOM   459  C  C   . ASP   A 1 69  ? -31.678 -42.017  -5.980  1.00 67.53  ? 70   ASP   A C   1 
ATOM   460  O  O   . ASP   A 1 69  ? -32.226 -43.127  -5.902  1.00 63.79  ? 70   ASP   A O   1 
ATOM   461  C  CB  . ASP   A 1 69  ? -29.198 -42.497  -5.916  1.00 68.34  ? 70   ASP   A CB  1 
ATOM   462  C  CG  . ASP   A 1 69  ? -28.732 -41.625  -4.761  1.00 68.75  ? 70   ASP   A CG  1 
ATOM   463  O  OD1 . ASP   A 1 69  ? -28.836 -40.391  -4.881  1.00 68.39  ? 70   ASP   A OD1 1 
ATOM   464  O  OD2 . ASP   A 1 69  ? -28.246 -42.191  -3.758  1.00 69.99  ? 70   ASP   A OD2 1 
ATOM   465  N  N   . LEU   A 1 70  ? -32.193 -40.903  -5.450  1.00 69.29  ? 71   LEU   A N   1 
ATOM   466  C  CA  . LEU   A 1 70  ? -33.449 -40.881  -4.653  1.00 70.80  ? 71   LEU   A CA  1 
ATOM   467  C  C   . LEU   A 1 70  ? -34.672 -41.113  -5.553  1.00 70.83  ? 71   LEU   A C   1 
ATOM   468  O  O   . LEU   A 1 70  ? -35.767 -41.292  -4.992  1.00 73.16  ? 71   LEU   A O   1 
ATOM   469  C  CB  . LEU   A 1 70  ? -33.557 -39.546  -3.908  1.00 70.48  ? 71   LEU   A CB  1 
ATOM   470  C  CG  . LEU   A 1 70  ? -32.467 -39.271  -2.872  1.00 70.81  ? 71   LEU   A CG  1 
ATOM   471  C  CD1 . LEU   A 1 70  ? -32.652 -37.894  -2.258  1.00 70.60  ? 71   LEU   A CD1 1 
ATOM   472  C  CD2 . LEU   A 1 70  ? -32.446 -40.333  -1.781  1.00 69.93  ? 71   LEU   A CD2 1 
ATOM   473  N  N   . LEU   A 1 71  ? -34.505 -41.130  -6.882  1.00 71.37  ? 72   LEU   A N   1 
ATOM   474  C  CA  . LEU   A 1 71  ? -35.622 -41.300  -7.856  1.00 70.21  ? 72   LEU   A CA  1 
ATOM   475  C  C   . LEU   A 1 71  ? -36.131 -42.747  -7.865  1.00 70.91  ? 72   LEU   A C   1 
ATOM   476  O  O   . LEU   A 1 71  ? -37.272 -42.951  -8.313  1.00 72.99  ? 72   LEU   A O   1 
ATOM   477  C  CB  . LEU   A 1 71  ? -35.160 -40.872  -9.251  1.00 70.11  ? 72   LEU   A CB  1 
ATOM   478  C  CG  . LEU   A 1 71  ? -34.915 -39.375  -9.428  1.00 72.65  ? 72   LEU   A CG  1 
ATOM   479  C  CD1 . LEU   A 1 71  ? -34.375 -39.078  -10.816 1.00 74.72  ? 72   LEU   A CD1 1 
ATOM   480  C  CD2 . LEU   A 1 71  ? -36.183 -38.576  -9.172  1.00 72.22  ? 72   LEU   A CD2 1 
ATOM   481  N  N   . LEU   A 1 72  ? -35.331 -43.712  -7.402  1.00 72.57  ? 73   LEU   A N   1 
ATOM   482  C  CA  . LEU   A 1 72  ? -35.748 -45.133  -7.249  1.00 72.54  ? 73   LEU   A CA  1 
ATOM   483  C  C   . LEU   A 1 72  ? -35.373 -45.626  -5.851  1.00 71.38  ? 73   LEU   A C   1 
ATOM   484  O  O   . LEU   A 1 72  ? -34.411 -45.084  -5.267  1.00 75.28  ? 73   LEU   A O   1 
ATOM   485  C  CB  . LEU   A 1 72  ? -35.055 -45.999  -8.304  1.00 76.15  ? 73   LEU   A CB  1 
ATOM   486  C  CG  . LEU   A 1 72  ? -35.443 -45.747  -9.760  1.00 78.95  ? 73   LEU   A CG  1 
ATOM   487  C  CD1 . LEU   A 1 72  ? -34.550 -46.553  -10.695 1.00 77.29  ? 73   LEU   A CD1 1 
ATOM   488  C  CD2 . LEU   A 1 72  ? -36.907 -46.084  -10.003 1.00 81.26  ? 73   LEU   A CD2 1 
ATOM   489  N  N   . SER   A 1 73  ? -36.095 -46.633  -5.356  1.00 68.59  ? 74   SER   A N   1 
ATOM   490  C  CA  . SER   A 1 73  ? -35.682 -47.463  -4.196  1.00 69.52  ? 74   SER   A CA  1 
ATOM   491  C  C   . SER   A 1 73  ? -34.342 -48.131  -4.523  1.00 70.49  ? 74   SER   A C   1 
ATOM   492  O  O   . SER   A 1 73  ? -34.098 -48.424  -5.715  1.00 67.00  ? 74   SER   A O   1 
ATOM   493  C  CB  . SER   A 1 73  ? -36.729 -48.496  -3.845  1.00 69.71  ? 74   SER   A CB  1 
ATOM   494  O  OG  . SER   A 1 73  ? -36.870 -49.458  -4.881  1.00 67.10  ? 74   SER   A OG  1 
ATOM   495  N  N   . GLY   A 1 74  ? -33.507 -48.357  -3.506  1.00 71.51  ? 75   GLY   A N   1 
ATOM   496  C  CA  . GLY   A 1 74  ? -32.340 -49.251  -3.603  1.00 70.73  ? 75   GLY   A CA  1 
ATOM   497  C  C   . GLY   A 1 74  ? -32.728 -50.557  -4.271  1.00 70.05  ? 75   GLY   A C   1 
ATOM   498  O  O   . GLY   A 1 74  ? -32.017 -50.976  -5.203  1.00 72.32  ? 75   GLY   A O   1 
ATOM   499  N  N   . ARG   A 1 75  ? -33.844 -51.152  -3.838  1.00 72.12  ? 76   ARG   A N   1 
ATOM   500  C  CA  . ARG   A 1 75  ? -34.391 -52.428  -4.378  1.00 74.43  ? 76   ARG   A CA  1 
ATOM   501  C  C   . ARG   A 1 75  ? -34.468 -52.348  -5.912  1.00 71.32  ? 76   ARG   A C   1 
ATOM   502  O  O   . ARG   A 1 75  ? -33.920 -53.244  -6.577  1.00 67.08  ? 76   ARG   A O   1 
ATOM   503  C  CB  . ARG   A 1 75  ? -35.753 -52.724  -3.735  1.00 80.12  ? 76   ARG   A CB  1 
ATOM   504  C  CG  . ARG   A 1 75  ? -36.410 -54.018  -4.196  1.00 84.43  ? 76   ARG   A CG  1 
ATOM   505  C  CD  . ARG   A 1 75  ? -35.540 -55.236  -3.956  1.00 92.93  ? 76   ARG   A CD  1 
ATOM   506  N  NE  . ARG   A 1 75  ? -36.198 -56.468  -4.371  1.00 100.72 ? 76   ARG   A NE  1 
ATOM   507  C  CZ  . ARG   A 1 75  ? -35.592 -57.644  -4.533  1.00 102.82 ? 76   ARG   A CZ  1 
ATOM   508  N  NH1 . ARG   A 1 75  ? -36.296 -58.695  -4.920  1.00 101.93 ? 76   ARG   A NH1 1 
ATOM   509  N  NH2 . ARG   A 1 75  ? -34.292 -57.771  -4.317  1.00 104.42 ? 76   ARG   A NH2 1 
ATOM   510  N  N   . ASP   A 1 76  ? -35.111 -51.309  -6.452  1.00 70.42  ? 77   ASP   A N   1 
ATOM   511  C  CA  . ASP   A 1 76  ? -35.323 -51.130  -7.915  1.00 72.22  ? 77   ASP   A CA  1 
ATOM   512  C  C   . ASP   A 1 76  ? -33.961 -51.040  -8.615  1.00 70.05  ? 77   ASP   A C   1 
ATOM   513  O  O   . ASP   A 1 76  ? -33.760 -51.777  -9.604  1.00 68.90  ? 77   ASP   A O   1 
ATOM   514  C  CB  . ASP   A 1 76  ? -36.210 -49.915  -8.214  1.00 74.73  ? 77   ASP   A CB  1 
ATOM   515  C  CG  . ASP   A 1 76  ? -37.679 -50.099  -7.854  1.00 76.55  ? 77   ASP   A CG  1 
ATOM   516  O  OD1 . ASP   A 1 76  ? -38.077 -51.246  -7.550  1.00 72.71  ? 77   ASP   A OD1 1 
ATOM   517  O  OD2 . ASP   A 1 76  ? -38.416 -49.089  -7.873  1.00 78.83  ? 77   ASP   A OD2 1 
ATOM   518  N  N   . TRP   A 1 77  ? -33.061 -50.181  -8.122  1.00 67.00  ? 78   TRP   A N   1 
ATOM   519  C  CA  . TRP   A 1 77  ? -31.690 -50.002  -8.674  1.00 65.15  ? 78   TRP   A CA  1 
ATOM   520  C  C   . TRP   A 1 77  ? -30.992 -51.367  -8.779  1.00 65.29  ? 78   TRP   A C   1 
ATOM   521  O  O   . TRP   A 1 77  ? -30.439 -51.666  -9.856  1.00 66.97  ? 78   TRP   A O   1 
ATOM   522  C  CB  . TRP   A 1 77  ? -30.858 -49.041  -7.820  1.00 64.05  ? 78   TRP   A CB  1 
ATOM   523  C  CG  . TRP   A 1 77  ? -31.161 -47.578  -7.945  1.00 64.85  ? 78   TRP   A CG  1 
ATOM   524  C  CD1 . TRP   A 1 77  ? -31.498 -46.746  -6.919  1.00 66.56  ? 78   TRP   A CD1 1 
ATOM   525  C  CD2 . TRP   A 1 77  ? -31.076 -46.743  -9.120  1.00 66.75  ? 78   TRP   A CD2 1 
ATOM   526  N  NE1 . TRP   A 1 77  ? -31.643 -45.464  -7.370  1.00 66.91  ? 78   TRP   A NE1 1 
ATOM   527  C  CE2 . TRP   A 1 77  ? -31.392 -45.427  -8.714  1.00 66.21  ? 78   TRP   A CE2 1 
ATOM   528  C  CE3 . TRP   A 1 77  ? -30.776 -46.967  -10.470 1.00 66.42  ? 78   TRP   A CE3 1 
ATOM   529  C  CZ2 . TRP   A 1 77  ? -31.429 -44.353  -9.604  1.00 66.01  ? 78   TRP   A CZ2 1 
ATOM   530  C  CZ3 . TRP   A 1 77  ? -30.812 -45.904  -11.350 1.00 66.22  ? 78   TRP   A CZ3 1 
ATOM   531  C  CH2 . TRP   A 1 77  ? -31.134 -44.615  -10.922 1.00 64.80  ? 78   TRP   A CH2 1 
ATOM   532  N  N   . ASN   A 1 78  ? -31.028 -52.162  -7.705  1.00 64.48  ? 79   ASN   A N   1 
ATOM   533  C  CA  . ASN   A 1 78  ? -30.289 -53.448  -7.576  1.00 66.14  ? 79   ASN   A CA  1 
ATOM   534  C  C   . ASN   A 1 78  ? -30.788 -54.500  -8.574  1.00 66.37  ? 79   ASN   A C   1 
ATOM   535  O  O   . ASN   A 1 78  ? -29.999 -55.413  -8.877  1.00 68.98  ? 79   ASN   A O   1 
ATOM   536  C  CB  . ASN   A 1 78  ? -30.416 -54.075  -6.183  1.00 68.07  ? 79   ASN   A CB  1 
ATOM   537  C  CG  . ASN   A 1 78  ? -29.590 -53.410  -5.102  1.00 70.08  ? 79   ASN   A CG  1 
ATOM   538  O  OD1 . ASN   A 1 78  ? -29.928 -53.521  -3.926  1.00 75.12  ? 79   ASN   A OD1 1 
ATOM   539  N  ND2 . ASN   A 1 78  ? -28.506 -52.739  -5.463  1.00 69.48  ? 79   ASN   A ND2 1 
ATOM   540  N  N   . THR   A 1 79  ? -32.046 -54.430  -9.021  1.00 66.77  ? 80   THR   A N   1 
ATOM   541  C  CA  . THR   A 1 79  ? -32.721 -55.569  -9.705  1.00 67.59  ? 80   THR   A CA  1 
ATOM   542  C  C   . THR   A 1 79  ? -33.282 -55.181  -11.079 1.00 67.53  ? 80   THR   A C   1 
ATOM   543  O  O   . THR   A 1 79  ? -33.250 -56.057  -11.969 1.00 70.87  ? 80   THR   A O   1 
ATOM   544  C  CB  . THR   A 1 79  ? -33.807 -56.173  -8.807  1.00 68.31  ? 80   THR   A CB  1 
ATOM   545  O  OG1 . THR   A 1 79  ? -34.726 -55.139  -8.457  1.00 74.15  ? 80   THR   A OG1 1 
ATOM   546  C  CG2 . THR   A 1 79  ? -33.242 -56.798  -7.551  1.00 67.79  ? 80   THR   A CG2 1 
ATOM   547  N  N   . LEU   A 1 80  ? -33.778 -53.950  -11.257 1.00 70.18  ? 81   LEU   A N   1 
ATOM   548  C  CA  . LEU   A 1 80  ? -34.565 -53.541  -12.455 1.00 71.90  ? 81   LEU   A CA  1 
ATOM   549  C  C   . LEU   A 1 80  ? -33.694 -52.804  -13.482 1.00 68.83  ? 81   LEU   A C   1 
ATOM   550  O  O   . LEU   A 1 80  ? -34.130 -52.721  -14.642 1.00 70.96  ? 81   LEU   A O   1 
ATOM   551  C  CB  . LEU   A 1 80  ? -35.736 -52.651  -12.020 1.00 75.90  ? 81   LEU   A CB  1 
ATOM   552  C  CG  . LEU   A 1 80  ? -36.745 -53.278  -11.057 1.00 75.62  ? 81   LEU   A CG  1 
ATOM   553  C  CD1 . LEU   A 1 80  ? -37.956 -52.374  -10.890 1.00 78.46  ? 81   LEU   A CD1 1 
ATOM   554  C  CD2 . LEU   A 1 80  ? -37.181 -54.659  -11.524 1.00 73.47  ? 81   LEU   A CD2 1 
ATOM   555  N  N   . ILE   A 1 81  ? -32.529 -52.280  -13.090 1.00 66.82  ? 82   ILE   A N   1 
ATOM   556  C  CA  . ILE   A 1 81  ? -31.762 -51.297  -13.915 1.00 66.88  ? 82   ILE   A CA  1 
ATOM   557  C  C   . ILE   A 1 81  ? -30.407 -51.881  -14.328 1.00 66.36  ? 82   ILE   A C   1 
ATOM   558  O  O   . ILE   A 1 81  ? -29.586 -52.157  -13.437 1.00 68.41  ? 82   ILE   A O   1 
ATOM   559  C  CB  . ILE   A 1 81  ? -31.602 -49.970  -13.151 1.00 69.07  ? 82   ILE   A CB  1 
ATOM   560  C  CG1 . ILE   A 1 81  ? -32.956 -49.410  -12.699 1.00 72.36  ? 82   ILE   A CG1 1 
ATOM   561  C  CG2 . ILE   A 1 81  ? -30.817 -48.962  -13.978 1.00 68.26  ? 82   ILE   A CG2 1 
ATOM   562  C  CD1 . ILE   A 1 81  ? -33.943 -49.155  -13.823 1.00 71.71  ? 82   ILE   A CD1 1 
ATOM   563  N  N   . VAL   A 1 82  ? -30.188 -52.026  -15.639 1.00 63.34  ? 83   VAL   A N   1 
ATOM   564  C  CA  . VAL   A 1 82  ? -28.853 -52.275  -16.260 1.00 62.03  ? 83   VAL   A CA  1 
ATOM   565  C  C   . VAL   A 1 82  ? -28.336 -50.946  -16.819 1.00 59.22  ? 83   VAL   A C   1 
ATOM   566  O  O   . VAL   A 1 82  ? -29.026 -50.357  -17.667 1.00 57.71  ? 83   VAL   A O   1 
ATOM   567  C  CB  . VAL   A 1 82  ? -28.934 -53.356  -17.354 1.00 62.85  ? 83   VAL   A CB  1 
ATOM   568  C  CG1 . VAL   A 1 82  ? -27.626 -53.490  -18.119 1.00 64.35  ? 83   VAL   A CG1 1 
ATOM   569  C  CG2 . VAL   A 1 82  ? -29.359 -54.697  -16.778 1.00 63.37  ? 83   VAL   A CG2 1 
ATOM   570  N  N   . GLY   A 1 83  ? -27.173 -50.484  -16.349 1.00 58.59  ? 84   GLY   A N   1 
ATOM   571  C  CA  . GLY   A 1 83  ? -26.531 -49.244  -16.826 1.00 57.70  ? 84   GLY   A CA  1 
ATOM   572  C  C   . GLY   A 1 83  ? -25.969 -49.402  -18.231 1.00 57.34  ? 84   GLY   A C   1 
ATOM   573  O  O   . GLY   A 1 83  ? -25.733 -50.548  -18.653 1.00 55.41  ? 84   GLY   A O   1 
ATOM   574  N  N   . LYS   A 1 84  ? -25.755 -48.284  -18.929 1.00 60.38  ? 85   LYS   A N   1 
ATOM   575  C  CA  . LYS   A 1 84  ? -25.185 -48.224  -20.302 1.00 60.38  ? 85   LYS   A CA  1 
ATOM   576  C  C   . LYS   A 1 84  ? -24.093 -47.154  -20.344 1.00 58.54  ? 85   LYS   A C   1 
ATOM   577  O  O   . LYS   A 1 84  ? -24.372 -46.006  -19.950 1.00 54.92  ? 85   LYS   A O   1 
ATOM   578  C  CB  . LYS   A 1 84  ? -26.266 -47.865  -21.327 1.00 63.73  ? 85   LYS   A CB  1 
ATOM   579  C  CG  . LYS   A 1 84  ? -27.355 -48.912  -21.523 1.00 65.84  ? 85   LYS   A CG  1 
ATOM   580  C  CD  . LYS   A 1 84  ? -28.415 -48.492  -22.515 1.00 65.33  ? 85   LYS   A CD  1 
ATOM   581  C  CE  . LYS   A 1 84  ? -27.951 -48.553  -23.954 1.00 66.28  ? 85   LYS   A CE  1 
ATOM   582  N  NZ  . LYS   A 1 84  ? -28.932 -47.924  -24.867 1.00 68.41  ? 85   LYS   A NZ  1 
ATOM   583  N  N   . LEU   A 1 85  ? -22.899 -47.509  -20.816 1.00 57.41  ? 86   LEU   A N   1 
ATOM   584  C  CA  . LEU   A 1 85  ? -21.825 -46.517  -21.073 1.00 59.57  ? 86   LEU   A CA  1 
ATOM   585  C  C   . LEU   A 1 85  ? -22.360 -45.481  -22.071 1.00 59.65  ? 86   LEU   A C   1 
ATOM   586  O  O   . LEU   A 1 85  ? -22.998 -45.876  -23.053 1.00 59.09  ? 86   LEU   A O   1 
ATOM   587  C  CB  . LEU   A 1 85  ? -20.585 -47.230  -21.618 1.00 57.44  ? 86   LEU   A CB  1 
ATOM   588  C  CG  . LEU   A 1 85  ? -19.337 -46.363  -21.764 1.00 59.04  ? 86   LEU   A CG  1 
ATOM   589  C  CD1 . LEU   A 1 85  ? -18.826 -45.916  -20.403 1.00 59.21  ? 86   LEU   A CD1 1 
ATOM   590  C  CD2 . LEU   A 1 85  ? -18.246 -47.112  -22.519 1.00 61.88  ? 86   LEU   A CD2 1 
ATOM   591  N  N   . SER   A 1 86  ? -22.137 -44.195  -21.810 1.00 62.44  ? 87   SER   A N   1 
ATOM   592  C  CA  . SER   A 1 86  ? -22.467 -43.103  -22.756 1.00 62.43  ? 87   SER   A CA  1 
ATOM   593  C  C   . SER   A 1 86  ? -21.702 -43.353  -24.055 1.00 64.52  ? 87   SER   A C   1 
ATOM   594  O  O   . SER   A 1 86  ? -20.527 -43.717  -24.027 1.00 66.30  ? 87   SER   A O   1 
ATOM   595  C  CB  . SER   A 1 86  ? -22.172 -41.757  -22.151 1.00 61.99  ? 87   SER   A CB  1 
ATOM   596  O  OG  . SER   A 1 86  ? -23.074 -41.489  -21.087 1.00 63.71  ? 87   SER   A OG  1 
ATOM   597  N  N   . PRO   A 1 87  ? -22.342 -43.187  -25.235 1.00 64.37  ? 88   PRO   A N   1 
ATOM   598  C  CA  . PRO   A 1 87  ? -21.752 -43.641  -26.494 1.00 61.23  ? 88   PRO   A CA  1 
ATOM   599  C  C   . PRO   A 1 87  ? -20.644 -42.727  -27.039 1.00 59.29  ? 88   PRO   A C   1 
ATOM   600  O  O   . PRO   A 1 87  ? -19.983 -43.137  -27.970 1.00 61.54  ? 88   PRO   A O   1 
ATOM   601  C  CB  . PRO   A 1 87  ? -22.965 -43.649  -27.433 1.00 62.62  ? 88   PRO   A CB  1 
ATOM   602  C  CG  . PRO   A 1 87  ? -23.813 -42.495  -26.936 1.00 63.20  ? 88   PRO   A CG  1 
ATOM   603  C  CD  . PRO   A 1 87  ? -23.644 -42.525  -25.429 1.00 64.36  ? 88   PRO   A CD  1 
ATOM   604  N  N   . TRP   A 1 88  ? -20.474 -41.529  -26.467 1.00 58.12  ? 89   TRP   A N   1 
ATOM   605  C  CA  . TRP   A 1 88  ? -19.379 -40.579  -26.814 1.00 56.85  ? 89   TRP   A CA  1 
ATOM   606  C  C   . TRP   A 1 88  ? -18.063 -41.019  -26.157 1.00 59.33  ? 89   TRP   A C   1 
ATOM   607  O  O   . TRP   A 1 88  ? -17.000 -40.552  -26.612 1.00 60.32  ? 89   TRP   A O   1 
ATOM   608  C  CB  . TRP   A 1 88  ? -19.745 -39.136  -26.431 1.00 54.83  ? 89   TRP   A CB  1 
ATOM   609  C  CG  . TRP   A 1 88  ? -19.917 -38.884  -24.962 1.00 53.57  ? 89   TRP   A CG  1 
ATOM   610  C  CD1 . TRP   A 1 88  ? -21.075 -38.958  -24.244 1.00 52.32  ? 89   TRP   A CD1 1 
ATOM   611  C  CD2 . TRP   A 1 88  ? -18.895 -38.487  -24.030 1.00 52.52  ? 89   TRP   A CD2 1 
ATOM   612  N  NE1 . TRP   A 1 88  ? -20.846 -38.645  -22.931 1.00 53.88  ? 89   TRP   A NE1 1 
ATOM   613  C  CE2 . TRP   A 1 88  ? -19.515 -38.356  -22.768 1.00 51.96  ? 89   TRP   A CE2 1 
ATOM   614  C  CE3 . TRP   A 1 88  ? -17.520 -38.246  -24.133 1.00 53.52  ? 89   TRP   A CE3 1 
ATOM   615  C  CZ2 . TRP   A 1 88  ? -18.803 -37.995  -21.625 1.00 49.18  ? 89   TRP   A CZ2 1 
ATOM   616  C  CZ3 . TRP   A 1 88  ? -16.820 -37.879  -23.005 1.00 52.56  ? 89   TRP   A CZ3 1 
ATOM   617  C  CH2 . TRP   A 1 88  ? -17.456 -37.757  -21.769 1.00 50.70  ? 89   TRP   A CH2 1 
ATOM   618  N  N   . ILE   A 1 89  ? -18.126 -41.870  -25.124 1.00 60.04  ? 90   ILE   A N   1 
ATOM   619  C  CA  . ILE   A 1 89  ? -16.931 -42.343  -24.360 1.00 59.06  ? 90   ILE   A CA  1 
ATOM   620  C  C   . ILE   A 1 89  ? -16.168 -43.319  -25.255 1.00 54.70  ? 90   ILE   A C   1 
ATOM   621  O  O   . ILE   A 1 89  ? -16.708 -44.414  -25.518 1.00 57.19  ? 90   ILE   A O   1 
ATOM   622  C  CB  . ILE   A 1 89  ? -17.331 -42.978  -23.012 1.00 60.90  ? 90   ILE   A CB  1 
ATOM   623  C  CG1 . ILE   A 1 89  ? -18.078 -41.982  -22.123 1.00 61.66  ? 90   ILE   A CG1 1 
ATOM   624  C  CG2 . ILE   A 1 89  ? -16.110 -43.546  -22.306 1.00 61.56  ? 90   ILE   A CG2 1 
ATOM   625  C  CD1 . ILE   A 1 89  ? -18.702 -42.596  -20.894 1.00 62.71  ? 90   ILE   A CD1 1 
ATOM   626  N  N   . ARG   A 1 90  ? -14.991 -42.908  -25.736 1.00 52.05  ? 91   ARG   A N   1 
ATOM   627  C  CA  . ARG   A 1 90  ? -14.149 -43.688  -26.682 1.00 54.18  ? 91   ARG   A CA  1 
ATOM   628  C  C   . ARG   A 1 90  ? -12.713 -43.718  -26.168 1.00 52.20  ? 91   ARG   A C   1 
ATOM   629  O  O   . ARG   A 1 90  ? -11.869 -42.941  -26.612 1.00 52.46  ? 91   ARG   A O   1 
ATOM   630  C  CB  . ARG   A 1 90  ? -14.243 -43.087  -28.088 1.00 56.94  ? 91   ARG   A CB  1 
ATOM   631  C  CG  . ARG   A 1 90  ? -15.646 -43.098  -28.681 1.00 60.76  ? 91   ARG   A CG  1 
ATOM   632  C  CD  . ARG   A 1 90  ? -16.013 -44.409  -29.356 1.00 63.49  ? 91   ARG   A CD  1 
ATOM   633  N  NE  . ARG   A 1 90  ? -16.300 -45.482  -28.413 1.00 69.38  ? 91   ARG   A NE  1 
ATOM   634  C  CZ  . ARG   A 1 90  ? -16.233 -46.786  -28.691 1.00 73.03  ? 91   ARG   A CZ  1 
ATOM   635  N  NH1 . ARG   A 1 90  ? -15.872 -47.204  -29.894 1.00 75.33  ? 91   ARG   A NH1 1 
ATOM   636  N  NH2 . ARG   A 1 90  ? -16.521 -47.675  -27.756 1.00 71.17  ? 91   ARG   A NH2 1 
ATOM   637  N  N   . PRO   A 1 91  ? -12.388 -44.632  -25.226 1.00 50.48  ? 92   PRO   A N   1 
ATOM   638  C  CA  . PRO   A 1 91  ? -11.056 -44.675  -24.618 1.00 51.30  ? 92   PRO   A CA  1 
ATOM   639  C  C   . PRO   A 1 91  ? -9.922  -45.004  -25.606 1.00 52.45  ? 92   PRO   A C   1 
ATOM   640  O  O   . PRO   A 1 91  ? -8.771  -44.757  -25.274 1.00 49.40  ? 92   PRO   A O   1 
ATOM   641  C  CB  . PRO   A 1 91  ? -11.171 -45.790  -23.565 1.00 51.76  ? 92   PRO   A CB  1 
ATOM   642  C  CG  . PRO   A 1 91  ? -12.660 -45.947  -23.333 1.00 51.22  ? 92   PRO   A CG  1 
ATOM   643  C  CD  . PRO   A 1 91  ? -13.288 -45.657  -24.679 1.00 49.70  ? 92   PRO   A CD  1 
ATOM   644  N  N   . ASP   A 1 92  ? -10.258 -45.552  -26.779 1.00 51.99  ? 93   ASP   A N   1 
ATOM   645  C  CA  . ASP   A 1 92  ? -9.267  -45.953  -27.811 1.00 54.54  ? 93   ASP   A CA  1 
ATOM   646  C  C   . ASP   A 1 92  ? -9.355  -45.026  -29.028 1.00 56.57  ? 93   ASP   A C   1 
ATOM   647  O  O   . ASP   A 1 92  ? -8.975  -45.471  -30.122 1.00 57.41  ? 93   ASP   A O   1 
ATOM   648  C  CB  . ASP   A 1 92  ? -9.444  -47.427  -28.169 1.00 55.42  ? 93   ASP   A CB  1 
ATOM   649  C  CG  . ASP   A 1 92  ? -8.996  -48.328  -27.037 1.00 54.93  ? 93   ASP   A CG  1 
ATOM   650  O  OD1 . ASP   A 1 92  ? -7.767  -48.503  -26.888 1.00 53.79  ? 93   ASP   A OD1 1 
ATOM   651  O  OD2 . ASP   A 1 92  ? -9.875  -48.795  -26.281 1.00 56.49  ? 93   ASP   A OD2 1 
ATOM   652  N  N   . SER   A 1 93  ? -9.788  -43.776  -28.832 1.00 59.72  ? 94   SER   A N   1 
ATOM   653  C  CA  . SER   A 1 93  ? -9.696  -42.685  -29.839 1.00 60.27  ? 94   SER   A CA  1 
ATOM   654  C  C   . SER   A 1 93  ? -8.225  -42.414  -30.182 1.00 61.86  ? 94   SER   A C   1 
ATOM   655  O  O   . SER   A 1 93  ? -7.353  -42.630  -29.312 1.00 58.83  ? 94   SER   A O   1 
ATOM   656  C  CB  . SER   A 1 93  ? -10.373 -41.425  -29.365 1.00 59.51  ? 94   SER   A CB  1 
ATOM   657  O  OG  . SER   A 1 93  ? -10.168 -40.365  -30.288 1.00 57.81  ? 94   SER   A OG  1 
ATOM   658  N  N   . LYS   A 1 94  ? -7.984  -41.931  -31.404 1.00 64.54  ? 95   LYS   A N   1 
ATOM   659  C  CA  . LYS   A 1 94  ? -6.645  -41.568  -31.933 1.00 68.28  ? 95   LYS   A CA  1 
ATOM   660  C  C   . LYS   A 1 94  ? -6.282  -40.157  -31.454 1.00 64.71  ? 95   LYS   A C   1 
ATOM   661  O  O   . LYS   A 1 94  ? -5.127  -39.745  -31.677 1.00 64.35  ? 95   LYS   A O   1 
ATOM   662  C  CB  . LYS   A 1 94  ? -6.637  -41.638  -33.465 1.00 76.71  ? 95   LYS   A CB  1 
ATOM   663  C  CG  . LYS   A 1 94  ? -7.208  -42.911  -34.085 1.00 81.68  ? 95   LYS   A CG  1 
ATOM   664  C  CD  . LYS   A 1 94  ? -6.553  -44.196  -33.602 1.00 87.09  ? 95   LYS   A CD  1 
ATOM   665  C  CE  . LYS   A 1 94  ? -5.102  -44.335  -34.014 1.00 88.85  ? 95   LYS   A CE  1 
ATOM   666  N  NZ  . LYS   A 1 94  ? -4.443  -45.458  -33.307 1.00 91.04  ? 95   LYS   A NZ  1 
ATOM   667  N  N   . VAL   A 1 95  ? -7.239  -39.446  -30.847 1.00 62.32  ? 96   VAL   A N   1 
ATOM   668  C  CA  . VAL   A 1 95  ? -7.075  -38.061  -30.308 1.00 63.34  ? 96   VAL   A CA  1 
ATOM   669  C  C   . VAL   A 1 95  ? -6.850  -38.155  -28.799 1.00 60.54  ? 96   VAL   A C   1 
ATOM   670  O  O   . VAL   A 1 95  ? -7.780  -38.614  -28.106 1.00 58.45  ? 96   VAL   A O   1 
ATOM   671  C  CB  . VAL   A 1 95  ? -8.308  -37.190  -30.623 1.00 63.57  ? 96   VAL   A CB  1 
ATOM   672  C  CG1 . VAL   A 1 95  ? -8.133  -35.759  -30.139 1.00 63.71  ? 96   VAL   A CG1 1 
ATOM   673  C  CG2 . VAL   A 1 95  ? -8.649  -37.212  -32.103 1.00 63.91  ? 96   VAL   A CG2 1 
ATOM   674  N  N   . GLU   A 1 96  ? -5.685  -37.708  -28.316 1.00 62.29  ? 97   GLU   A N   1 
ATOM   675  C  CA  . GLU   A 1 96  ? -5.265  -37.822  -26.890 1.00 66.95  ? 97   GLU   A CA  1 
ATOM   676  C  C   . GLU   A 1 96  ? -6.329  -37.194  -25.978 1.00 65.95  ? 97   GLU   A C   1 
ATOM   677  O  O   . GLU   A 1 96  ? -6.734  -37.855  -24.997 1.00 63.44  ? 97   GLU   A O   1 
ATOM   678  C  CB  . GLU   A 1 96  ? -3.899  -37.170  -26.658 1.00 68.75  ? 97   GLU   A CB  1 
ATOM   679  C  CG  . GLU   A 1 96  ? -3.388  -37.332  -25.234 1.00 70.49  ? 97   GLU   A CG  1 
ATOM   680  C  CD  . GLU   A 1 96  ? -1.911  -37.030  -25.035 1.00 75.00  ? 97   GLU   A CD  1 
ATOM   681  O  OE1 . GLU   A 1 96  ? -1.598  -36.142  -24.222 1.00 77.31  ? 97   GLU   A OE1 1 
ATOM   682  O  OE2 . GLU   A 1 96  ? -1.075  -37.696  -25.678 1.00 81.05  ? 97   GLU   A OE2 1 
ATOM   683  N  N   . LYS   A 1 97  ? -6.761  -35.969  -26.284 1.00 64.25  ? 98   LYS   A N   1 
ATOM   684  C  CA  . LYS   A 1 97  ? -7.739  -35.214  -25.454 1.00 67.26  ? 98   LYS   A CA  1 
ATOM   685  C  C   . LYS   A 1 97  ? -9.008  -36.054  -25.282 1.00 63.19  ? 98   LYS   A C   1 
ATOM   686  O  O   . LYS   A 1 97  ? -9.596  -36.016  -24.183 1.00 61.75  ? 98   LYS   A O   1 
ATOM   687  C  CB  . LYS   A 1 97  ? -8.057  -33.853  -26.080 1.00 71.16  ? 98   LYS   A CB  1 
ATOM   688  C  CG  . LYS   A 1 97  ? -7.005  -32.776  -25.848 1.00 72.96  ? 98   LYS   A CG  1 
ATOM   689  C  CD  . LYS   A 1 97  ? -7.262  -31.516  -26.644 1.00 75.31  ? 98   LYS   A CD  1 
ATOM   690  C  CE  . LYS   A 1 97  ? -6.232  -30.436  -26.399 1.00 77.41  ? 98   LYS   A CE  1 
ATOM   691  N  NZ  . LYS   A 1 97  ? -6.854  -29.092  -26.398 1.00 81.03  ? 98   LYS   A NZ  1 
ATOM   692  N  N   . ILE   A 1 98  ? -9.401  -36.795  -26.320 1.00 60.67  ? 99   ILE   A N   1 
ATOM   693  C  CA  . ILE   A 1 98  ? -10.640 -37.624  -26.309 1.00 61.15  ? 99   ILE   A CA  1 
ATOM   694  C  C   . ILE   A 1 98  ? -10.392 -38.875  -25.457 1.00 62.63  ? 99   ILE   A C   1 
ATOM   695  O  O   . ILE   A 1 98  ? -11.314 -39.246  -24.702 1.00 61.54  ? 99   ILE   A O   1 
ATOM   696  C  CB  . ILE   A 1 98  ? -11.113 -37.942  -27.742 1.00 61.73  ? 99   ILE   A CB  1 
ATOM   697  C  CG1 . ILE   A 1 98  ? -11.380 -36.647  -28.521 1.00 62.64  ? 99   ILE   A CG1 1 
ATOM   698  C  CG2 . ILE   A 1 98  ? -12.327 -38.866  -27.718 1.00 60.68  ? 99   ILE   A CG2 1 
ATOM   699  C  CD1 . ILE   A 1 98  ? -12.143 -36.821  -29.818 1.00 62.49  ? 99   ILE   A CD1 1 
ATOM   700  N  N   . ARG   A 1 99  ? -9.202  -39.486  -25.549 1.00 63.30  ? 100  ARG   A N   1 
ATOM   701  C  CA  . ARG   A 1 99  ? -8.827  -40.657  -24.707 1.00 67.55  ? 100  ARG   A CA  1 
ATOM   702  C  C   . ARG   A 1 99  ? -8.917  -40.260  -23.230 1.00 65.78  ? 100  ARG   A C   1 
ATOM   703  O  O   . ARG   A 1 99  ? -9.631  -40.951  -22.490 1.00 68.96  ? 100  ARG   A O   1 
ATOM   704  C  CB  . ARG   A 1 99  ? -7.424  -41.184  -25.017 1.00 70.97  ? 100  ARG   A CB  1 
ATOM   705  C  CG  . ARG   A 1 99  ? -7.331  -41.987  -26.305 1.00 76.43  ? 100  ARG   A CG  1 
ATOM   706  C  CD  . ARG   A 1 99  ? -6.126  -42.904  -26.296 1.00 80.79  ? 100  ARG   A CD  1 
ATOM   707  N  NE  . ARG   A 1 99  ? -4.898  -42.163  -26.044 1.00 82.61  ? 100  ARG   A NE  1 
ATOM   708  C  CZ  . ARG   A 1 99  ? -4.213  -41.479  -26.959 1.00 83.38  ? 100  ARG   A CZ  1 
ATOM   709  N  NH1 . ARG   A 1 99  ? -3.108  -40.841  -26.607 1.00 86.25  ? 100  ARG   A NH1 1 
ATOM   710  N  NH2 . ARG   A 1 99  ? -4.627  -41.430  -28.215 1.00 79.40  ? 100  ARG   A NH2 1 
ATOM   711  N  N   . ARG   A 1 100 ? -8.247  -39.175  -22.834 1.00 65.49  ? 101  ARG   A N   1 
ATOM   712  C  CA  . ARG   A 1 100 ? -8.147  -38.729  -21.417 1.00 67.25  ? 101  ARG   A CA  1 
ATOM   713  C  C   . ARG   A 1 100 ? -9.550  -38.411  -20.875 1.00 65.79  ? 101  ARG   A C   1 
ATOM   714  O  O   . ARG   A 1 100 ? -9.843  -38.842  -19.748 1.00 66.08  ? 101  ARG   A O   1 
ATOM   715  C  CB  . ARG   A 1 100 ? -7.146  -37.577  -21.295 1.00 68.72  ? 101  ARG   A CB  1 
ATOM   716  C  CG  . ARG   A 1 100 ? -5.708  -38.015  -21.537 1.00 77.59  ? 101  ARG   A CG  1 
ATOM   717  C  CD  . ARG   A 1 100 ? -4.698  -36.881  -21.530 1.00 85.31  ? 101  ARG   A CD  1 
ATOM   718  N  NE  . ARG   A 1 100 ? -3.325  -37.361  -21.655 1.00 89.71  ? 101  ARG   A NE  1 
ATOM   719  C  CZ  . ARG   A 1 100 ? -2.637  -37.986  -20.701 1.00 95.95  ? 101  ARG   A CZ  1 
ATOM   720  N  NH1 . ARG   A 1 100 ? -3.187  -38.232  -19.523 1.00 101.51 ? 101  ARG   A NH1 1 
ATOM   721  N  NH2 . ARG   A 1 100 ? -1.394  -38.374  -20.929 1.00 97.25  ? 101  ARG   A NH2 1 
ATOM   722  N  N   . ASN   A 1 101 ? -10.402 -37.736  -21.651 1.00 63.51  ? 102  ASN   A N   1 
ATOM   723  C  CA  . ASN   A 1 101 ? -11.797 -37.409  -21.242 1.00 65.30  ? 102  ASN   A CA  1 
ATOM   724  C  C   . ASN   A 1 101 ? -12.626 -38.691  -21.118 1.00 62.36  ? 102  ASN   A C   1 
ATOM   725  O  O   . ASN   A 1 101 ? -13.412 -38.800  -20.151 1.00 61.91  ? 102  ASN   A O   1 
ATOM   726  C  CB  . ASN   A 1 101 ? -12.503 -36.458  -22.215 1.00 66.82  ? 102  ASN   A CB  1 
ATOM   727  C  CG  . ASN   A 1 101 ? -12.530 -35.018  -21.749 1.00 68.85  ? 102  ASN   A CG  1 
ATOM   728  O  OD1 . ASN   A 1 101 ? -12.282 -34.719  -20.583 1.00 68.48  ? 102  ASN   A OD1 1 
ATOM   729  N  ND2 . ASN   A 1 101 ? -12.831 -34.113  -22.663 1.00 75.92  ? 102  ASN   A ND2 1 
ATOM   730  N  N   . SER   A 1 102 ? -12.490 -39.610  -22.076 1.00 57.12  ? 103  SER   A N   1 
ATOM   731  C  CA  . SER   A 1 102 ? -13.270 -40.875  -22.116 1.00 55.97  ? 103  SER   A CA  1 
ATOM   732  C  C   . SER   A 1 102 ? -12.828 -41.801  -20.970 1.00 54.11  ? 103  SER   A C   1 
ATOM   733  O  O   . SER   A 1 102 ? -13.686 -42.509  -20.420 1.00 51.30  ? 103  SER   A O   1 
ATOM   734  C  CB  . SER   A 1 102 ? -13.154 -41.535  -23.463 1.00 54.63  ? 103  SER   A CB  1 
ATOM   735  O  OG  . SER   A 1 102 ? -13.554 -40.653  -24.501 1.00 49.15  ? 103  SER   A OG  1 
ATOM   736  N  N   . GLU   A 1 103 ? -11.540 -41.781  -20.616 1.00 53.79  ? 104  GLU   A N   1 
ATOM   737  C  CA  . GLU   A 1 103 ? -10.997 -42.464  -19.413 1.00 56.11  ? 104  GLU   A CA  1 
ATOM   738  C  C   . GLU   A 1 103 ? -11.785 -41.978  -18.187 1.00 55.30  ? 104  GLU   A C   1 
ATOM   739  O  O   . GLU   A 1 103 ? -12.547 -42.786  -17.617 1.00 55.01  ? 104  GLU   A O   1 
ATOM   740  C  CB  . GLU   A 1 103 ? -9.492  -42.210  -19.297 1.00 59.97  ? 104  GLU   A CB  1 
ATOM   741  C  CG  . GLU   A 1 103 ? -8.659  -43.024  -20.281 1.00 62.55  ? 104  GLU   A CG  1 
ATOM   742  C  CD  . GLU   A 1 103 ? -7.193  -42.628  -20.422 1.00 63.51  ? 104  GLU   A CD  1 
ATOM   743  O  OE1 . GLU   A 1 103 ? -6.710  -41.809  -19.609 1.00 67.08  ? 104  GLU   A OE1 1 
ATOM   744  O  OE2 . GLU   A 1 103 ? -6.531  -43.149  -21.345 1.00 59.50  ? 104  GLU   A OE2 1 
ATOM   745  N  N   . ALA   A 1 104 ? -11.644 -40.697  -17.828 1.00 52.78  ? 105  ALA   A N   1 
ATOM   746  C  CA  . ALA   A 1 104 ? -12.329 -40.053  -16.681 1.00 54.68  ? 105  ALA   A CA  1 
ATOM   747  C  C   . ALA   A 1 104 ? -13.838 -40.354  -16.704 1.00 54.75  ? 105  ALA   A C   1 
ATOM   748  O  O   . ALA   A 1 104 ? -14.389 -40.714  -15.641 1.00 54.87  ? 105  ALA   A O   1 
ATOM   749  C  CB  . ALA   A 1 104 ? -12.073 -38.567  -16.693 1.00 53.31  ? 105  ALA   A CB  1 
ATOM   750  N  N   . ALA   A 1 105 ? -14.477 -40.218  -17.867 1.00 53.66  ? 106  ALA   A N   1 
ATOM   751  C  CA  . ALA   A 1 105 ? -15.942 -40.344  -18.052 1.00 55.84  ? 106  ALA   A CA  1 
ATOM   752  C  C   . ALA   A 1 105 ? -16.385 -41.791  -17.813 1.00 56.74  ? 106  ALA   A C   1 
ATOM   753  O  O   . ALA   A 1 105 ? -17.461 -41.998  -17.217 1.00 58.23  ? 106  ALA   A O   1 
ATOM   754  C  CB  . ALA   A 1 105 ? -16.320 -39.885  -19.438 1.00 57.33  ? 106  ALA   A CB  1 
ATOM   755  N  N   . MET   A 1 106 ? -15.596 -42.754  -18.289 1.00 57.25  ? 107  MET   A N   1 
ATOM   756  C  CA  . MET   A 1 106 ? -15.871 -44.204  -18.120 1.00 55.64  ? 107  MET   A CA  1 
ATOM   757  C  C   . MET   A 1 106 ? -15.812 -44.545  -16.626 1.00 55.02  ? 107  MET   A C   1 
ATOM   758  O  O   . MET   A 1 106 ? -16.778 -45.147  -16.124 1.00 57.21  ? 107  MET   A O   1 
ATOM   759  C  CB  . MET   A 1 106 ? -14.853 -45.042  -18.895 1.00 54.29  ? 107  MET   A CB  1 
ATOM   760  C  CG  . MET   A 1 106 ? -15.177 -46.515  -18.922 1.00 54.99  ? 107  MET   A CG  1 
ATOM   761  S  SD  . MET   A 1 106 ? -14.020 -47.440  -19.960 1.00 54.92  ? 107  MET   A SD  1 
ATOM   762  C  CE  . MET   A 1 106 ? -14.339 -49.106  -19.381 1.00 53.14  ? 107  MET   A CE  1 
ATOM   763  N  N   . LEU   A 1 107 ? -14.733 -44.152  -15.944 1.00 55.03  ? 108  LEU   A N   1 
ATOM   764  C  CA  . LEU   A 1 107 ? -14.561 -44.364  -14.480 1.00 57.92  ? 108  LEU   A CA  1 
ATOM   765  C  C   . LEU   A 1 107 ? -15.738 -43.724  -13.742 1.00 54.54  ? 108  LEU   A C   1 
ATOM   766  O  O   . LEU   A 1 107 ? -16.335 -44.398  -12.893 1.00 52.80  ? 108  LEU   A O   1 
ATOM   767  C  CB  . LEU   A 1 107 ? -13.232 -43.762  -14.011 1.00 60.28  ? 108  LEU   A CB  1 
ATOM   768  C  CG  . LEU   A 1 107 ? -11.984 -44.559  -14.380 1.00 63.35  ? 108  LEU   A CG  1 
ATOM   769  C  CD1 . LEU   A 1 107 ? -10.731 -43.861  -13.868 1.00 63.14  ? 108  LEU   A CD1 1 
ATOM   770  C  CD2 . LEU   A 1 107 ? -12.068 -45.983  -13.843 1.00 65.11  ? 108  LEU   A CD2 1 
ATOM   771  N  N   . GLN   A 1 108 ? -16.045 -42.470  -14.074 1.00 55.27  ? 109  GLN   A N   1 
ATOM   772  C  CA  . GLN   A 1 108 ? -17.172 -41.697  -13.496 1.00 55.78  ? 109  GLN   A CA  1 
ATOM   773  C  C   . GLN   A 1 108 ? -18.448 -42.538  -13.596 1.00 55.15  ? 109  GLN   A C   1 
ATOM   774  O  O   . GLN   A 1 108 ? -19.052 -42.820  -12.546 1.00 60.53  ? 109  GLN   A O   1 
ATOM   775  C  CB  . GLN   A 1 108 ? -17.306 -40.364  -14.229 1.00 56.47  ? 109  GLN   A CB  1 
ATOM   776  C  CG  . GLN   A 1 108 ? -18.405 -39.460  -13.693 1.00 57.00  ? 109  GLN   A CG  1 
ATOM   777  C  CD  . GLN   A 1 108 ? -18.566 -38.246  -14.572 1.00 56.78  ? 109  GLN   A CD  1 
ATOM   778  O  OE1 . GLN   A 1 108 ? -18.503 -38.333  -15.795 1.00 56.91  ? 109  GLN   A OE1 1 
ATOM   779  N  NE2 . GLN   A 1 108 ? -18.773 -37.096  -13.956 1.00 60.00  ? 109  GLN   A NE2 1 
ATOM   780  N  N   . GLU   A 1 109 ? -18.817 -42.943  -14.811 1.00 55.61  ? 110  GLU   A N   1 
ATOM   781  C  CA  . GLU   A 1 109 ? -20.086 -43.665  -15.091 1.00 56.27  ? 110  GLU   A CA  1 
ATOM   782  C  C   . GLU   A 1 109 ? -20.046 -45.042  -14.428 1.00 55.36  ? 110  GLU   A C   1 
ATOM   783  O  O   . GLU   A 1 109 ? -21.078 -45.444  -13.861 1.00 56.06  ? 110  GLU   A O   1 
ATOM   784  C  CB  . GLU   A 1 109 ? -20.323 -43.789  -16.596 1.00 58.95  ? 110  GLU   A CB  1 
ATOM   785  C  CG  . GLU   A 1 109 ? -20.634 -42.464  -17.263 1.00 59.59  ? 110  GLU   A CG  1 
ATOM   786  C  CD  . GLU   A 1 109 ? -21.259 -42.546  -18.645 1.00 60.42  ? 110  GLU   A CD  1 
ATOM   787  O  OE1 . GLU   A 1 109 ? -21.468 -43.672  -19.156 1.00 58.23  ? 110  GLU   A OE1 1 
ATOM   788  O  OE2 . GLU   A 1 109 ? -21.534 -41.475  -19.208 1.00 62.70  ? 110  GLU   A OE2 1 
ATOM   789  N  N   . LEU   A 1 110 ? -18.907 -45.740  -14.508 1.00 55.44  ? 111  LEU   A N   1 
ATOM   790  C  CA  . LEU   A 1 110 ? -18.728 -47.083  -13.889 1.00 55.17  ? 111  LEU   A CA  1 
ATOM   791  C  C   . LEU   A 1 110 ? -18.821 -46.955  -12.364 1.00 53.71  ? 111  LEU   A C   1 
ATOM   792  O  O   . LEU   A 1 110 ? -19.468 -47.812  -11.749 1.00 57.05  ? 111  LEU   A O   1 
ATOM   793  C  CB  . LEU   A 1 110 ? -17.389 -47.692  -14.320 1.00 54.95  ? 111  LEU   A CB  1 
ATOM   794  C  CG  . LEU   A 1 110 ? -17.365 -48.316  -15.714 1.00 54.20  ? 111  LEU   A CG  1 
ATOM   795  C  CD1 . LEU   A 1 110 ? -15.962 -48.772  -16.068 1.00 56.01  ? 111  LEU   A CD1 1 
ATOM   796  C  CD2 . LEU   A 1 110 ? -18.336 -49.481  -15.820 1.00 52.76  ? 111  LEU   A CD2 1 
ATOM   797  N  N   . ASN   A 1 111 ? -18.221 -45.910  -11.790 1.00 53.16  ? 112  ASN   A N   1 
ATOM   798  C  CA  . ASN   A 1 111 ? -18.249 -45.631  -10.330 1.00 54.65  ? 112  ASN   A CA  1 
ATOM   799  C  C   . ASN   A 1 111 ? -19.686 -45.331  -9.891  1.00 58.04  ? 112  ASN   A C   1 
ATOM   800  O  O   . ASN   A 1 111 ? -20.076 -45.811  -8.807  1.00 62.65  ? 112  ASN   A O   1 
ATOM   801  C  CB  . ASN   A 1 111 ? -17.279 -44.513  -9.939  1.00 52.35  ? 112  ASN   A CB  1 
ATOM   802  C  CG  . ASN   A 1 111 ? -15.832 -44.968  -9.931  1.00 51.84  ? 112  ASN   A CG  1 
ATOM   803  O  OD1 . ASN   A 1 111 ? -15.544 -46.160  -9.833  1.00 47.60  ? 112  ASN   A OD1 1 
ATOM   804  N  ND2 . ASN   A 1 111 ? -14.908 -44.027  -10.030 1.00 53.14  ? 112  ASN   A ND2 1 
ATOM   805  N  N   . PHE   A 1 112 ? -20.456 -44.589  -10.693 1.00 56.41  ? 113  PHE   A N   1 
ATOM   806  C  CA  . PHE   A 1 112 ? -21.880 -44.289  -10.390 1.00 57.18  ? 113  PHE   A CA  1 
ATOM   807  C  C   . PHE   A 1 112 ? -22.699 -45.587  -10.425 1.00 56.98  ? 113  PHE   A C   1 
ATOM   808  O  O   . PHE   A 1 112 ? -23.566 -45.767  -9.557  1.00 58.83  ? 113  PHE   A O   1 
ATOM   809  C  CB  . PHE   A 1 112 ? -22.452 -43.229  -11.332 1.00 57.77  ? 113  PHE   A CB  1 
ATOM   810  C  CG  . PHE   A 1 112 ? -23.635 -42.501  -10.748 1.00 59.19  ? 113  PHE   A CG  1 
ATOM   811  C  CD1 . PHE   A 1 112 ? -23.467 -41.637  -9.676  1.00 59.18  ? 113  PHE   A CD1 1 
ATOM   812  C  CD2 . PHE   A 1 112 ? -24.914 -42.702  -11.243 1.00 59.43  ? 113  PHE   A CD2 1 
ATOM   813  C  CE1 . PHE   A 1 112 ? -24.552 -40.976  -9.122  1.00 59.65  ? 113  PHE   A CE1 1 
ATOM   814  C  CE2 . PHE   A 1 112 ? -25.997 -42.037  -10.690 1.00 60.79  ? 113  PHE   A CE2 1 
ATOM   815  C  CZ  . PHE   A 1 112 ? -25.814 -41.176  -9.631  1.00 61.15  ? 113  PHE   A CZ  1 
ATOM   816  N  N   . GLY   A 1 113 ? -22.432 -46.468  -11.392 1.00 57.65  ? 114  GLY   A N   1 
ATOM   817  C  CA  . GLY   A 1 113 ? -23.091 -47.783  -11.484 1.00 57.95  ? 114  GLY   A CA  1 
ATOM   818  C  C   . GLY   A 1 113 ? -22.942 -48.550  -10.184 1.00 60.56  ? 114  GLY   A C   1 
ATOM   819  O  O   . GLY   A 1 113 ? -23.956 -49.086  -9.682  1.00 63.39  ? 114  GLY   A O   1 
ATOM   820  N  N   . ALA   A 1 114 ? -21.720 -48.580  -9.647  1.00 59.14  ? 115  ALA   A N   1 
ATOM   821  C  CA  . ALA   A 1 114 ? -21.357 -49.265  -8.386  1.00 60.48  ? 115  ALA   A CA  1 
ATOM   822  C  C   . ALA   A 1 114 ? -22.067 -48.589  -7.207  1.00 60.79  ? 115  ALA   A C   1 
ATOM   823  O  O   . ALA   A 1 114 ? -22.584 -49.315  -6.335  1.00 64.02  ? 115  ALA   A O   1 
ATOM   824  C  CB  . ALA   A 1 114 ? -19.859 -49.251  -8.209  1.00 61.94  ? 115  ALA   A CB  1 
ATOM   825  N  N   . TYR   A 1 115 ? -22.087 -47.253  -7.187  1.00 58.07  ? 116  TYR   A N   1 
ATOM   826  C  CA  . TYR   A 1 115 ? -22.753 -46.422  -6.150  1.00 57.42  ? 116  TYR   A CA  1 
ATOM   827  C  C   . TYR   A 1 115 ? -24.242 -46.782  -6.093  1.00 58.41  ? 116  TYR   A C   1 
ATOM   828  O  O   . TYR   A 1 115 ? -24.782 -46.921  -4.977  1.00 57.65  ? 116  TYR   A O   1 
ATOM   829  C  CB  . TYR   A 1 115 ? -22.512 -44.940  -6.435  1.00 57.09  ? 116  TYR   A CB  1 
ATOM   830  C  CG  . TYR   A 1 115 ? -23.310 -43.968  -5.604  1.00 59.29  ? 116  TYR   A CG  1 
ATOM   831  C  CD1 . TYR   A 1 115 ? -22.918 -43.621  -4.321  1.00 59.13  ? 116  TYR   A CD1 1 
ATOM   832  C  CD2 . TYR   A 1 115 ? -24.423 -43.336  -6.132  1.00 60.75  ? 116  TYR   A CD2 1 
ATOM   833  C  CE1 . TYR   A 1 115 ? -23.629 -42.697  -3.572  1.00 60.35  ? 116  TYR   A CE1 1 
ATOM   834  C  CE2 . TYR   A 1 115 ? -25.146 -42.411  -5.397  1.00 63.12  ? 116  TYR   A CE2 1 
ATOM   835  C  CZ  . TYR   A 1 115 ? -24.751 -42.090  -4.112  1.00 63.37  ? 116  TYR   A CZ  1 
ATOM   836  O  OH  . TYR   A 1 115 ? -25.467 -41.170  -3.401  1.00 65.50  ? 116  TYR   A OH  1 
ATOM   837  N  N   . LEU   A 1 116 ? -24.869 -46.967  -7.258  1.00 56.94  ? 117  LEU   A N   1 
ATOM   838  C  CA  . LEU   A 1 116 ? -26.307 -47.332  -7.380  1.00 59.68  ? 117  LEU   A CA  1 
ATOM   839  C  C   . LEU   A 1 116 ? -26.510 -48.815  -7.050  1.00 57.49  ? 117  LEU   A C   1 
ATOM   840  O  O   . LEU   A 1 116 ? -27.663 -49.198  -6.804  1.00 55.60  ? 117  LEU   A O   1 
ATOM   841  C  CB  . LEU   A 1 116 ? -26.799 -47.020  -8.798  1.00 60.21  ? 117  LEU   A CB  1 
ATOM   842  C  CG  . LEU   A 1 116 ? -26.849 -45.543  -9.184  1.00 58.78  ? 117  LEU   A CG  1 
ATOM   843  C  CD1 . LEU   A 1 116 ? -27.473 -45.371  -10.558 1.00 60.64  ? 117  LEU   A CD1 1 
ATOM   844  C  CD2 . LEU   A 1 116 ? -27.611 -44.726  -8.155  1.00 58.92  ? 117  LEU   A CD2 1 
ATOM   845  N  N   . GLY   A 1 117 ? -25.439 -49.615  -7.064  1.00 58.57  ? 118  GLY   A N   1 
ATOM   846  C  CA  . GLY   A 1 117 ? -25.493 -51.073  -6.843  1.00 57.04  ? 118  GLY   A CA  1 
ATOM   847  C  C   . GLY   A 1 117 ? -26.184 -51.781  -7.996  1.00 58.69  ? 118  GLY   A C   1 
ATOM   848  O  O   . GLY   A 1 117 ? -26.886 -52.779  -7.743  1.00 60.23  ? 118  GLY   A O   1 
ATOM   849  N  N   . LEU   A 1 118 ? -25.991 -51.292  -9.224  1.00 59.18  ? 119  LEU   A N   1 
ATOM   850  C  CA  . LEU   A 1 118 ? -26.586 -51.896  -10.445 1.00 61.02  ? 119  LEU   A CA  1 
ATOM   851  C  C   . LEU   A 1 118 ? -26.075 -53.328  -10.577 1.00 61.78  ? 119  LEU   A C   1 
ATOM   852  O  O   . LEU   A 1 118 ? -24.904 -53.602  -10.305 1.00 63.27  ? 119  LEU   A O   1 
ATOM   853  C  CB  . LEU   A 1 118 ? -26.222 -51.066  -11.681 1.00 61.15  ? 119  LEU   A CB  1 
ATOM   854  C  CG  . LEU   A 1 118 ? -26.667 -49.603  -11.666 1.00 60.87  ? 119  LEU   A CG  1 
ATOM   855  C  CD1 . LEU   A 1 118 ? -26.442 -48.963  -13.028 1.00 60.72  ? 119  LEU   A CD1 1 
ATOM   856  C  CD2 . LEU   A 1 118 ? -28.125 -49.463  -11.248 1.00 60.81  ? 119  LEU   A CD2 1 
ATOM   857  N  N   . PRO   A 1 119 ? -26.946 -54.284  -10.972 1.00 58.66  ? 120  PRO   A N   1 
ATOM   858  C  CA  . PRO   A 1 119 ? -26.560 -55.689  -11.086 1.00 59.38  ? 120  PRO   A CA  1 
ATOM   859  C  C   . PRO   A 1 119 ? -25.710 -55.965  -12.332 1.00 59.34  ? 120  PRO   A C   1 
ATOM   860  O  O   . PRO   A 1 119 ? -24.922 -56.889  -12.309 1.00 65.11  ? 120  PRO   A O   1 
ATOM   861  C  CB  . PRO   A 1 119 ? -27.909 -56.418  -11.175 1.00 59.84  ? 120  PRO   A CB  1 
ATOM   862  C  CG  . PRO   A 1 119 ? -28.828 -55.408  -11.827 1.00 59.62  ? 120  PRO   A CG  1 
ATOM   863  C  CD  . PRO   A 1 119 ? -28.355 -54.060  -11.320 1.00 58.68  ? 120  PRO   A CD  1 
ATOM   864  N  N   . ALA   A 1 120 ? -25.903 -55.171  -13.386 1.00 57.60  ? 121  ALA   A N   1 
ATOM   865  C  CA  . ALA   A 1 120 ? -25.152 -55.262  -14.656 1.00 57.63  ? 121  ALA   A CA  1 
ATOM   866  C  C   . ALA   A 1 120 ? -24.982 -53.866  -15.263 1.00 55.71  ? 121  ALA   A C   1 
ATOM   867  O  O   . ALA   A 1 120 ? -25.692 -52.933  -14.852 1.00 55.49  ? 121  ALA   A O   1 
ATOM   868  C  CB  . ALA   A 1 120 ? -25.858 -56.203  -15.602 1.00 60.30  ? 121  ALA   A CB  1 
ATOM   869  N  N   . PHE   A 1 121 ? -24.061 -53.744  -16.213 1.00 55.62  ? 122  PHE   A N   1 
ATOM   870  C  CA  . PHE   A 1 121 ? -23.672 -52.469  -16.866 1.00 56.78  ? 122  PHE   A CA  1 
ATOM   871  C  C   . PHE   A 1 121 ? -23.097 -52.825  -18.243 1.00 56.55  ? 122  PHE   A C   1 
ATOM   872  O  O   . PHE   A 1 121 ? -22.191 -53.689  -18.318 1.00 51.95  ? 122  PHE   A O   1 
ATOM   873  C  CB  . PHE   A 1 121 ? -22.722 -51.702  -15.941 1.00 57.89  ? 122  PHE   A CB  1 
ATOM   874  C  CG  . PHE   A 1 121 ? -22.422 -50.275  -16.324 1.00 61.73  ? 122  PHE   A CG  1 
ATOM   875  C  CD1 . PHE   A 1 121 ? -21.633 -49.979  -17.429 1.00 63.19  ? 122  PHE   A CD1 1 
ATOM   876  C  CD2 . PHE   A 1 121 ? -22.886 -49.222  -15.551 1.00 62.26  ? 122  PHE   A CD2 1 
ATOM   877  C  CE1 . PHE   A 1 121 ? -21.341 -48.667  -17.768 1.00 59.84  ? 122  PHE   A CE1 1 
ATOM   878  C  CE2 . PHE   A 1 121 ? -22.593 -47.909  -15.893 1.00 64.07  ? 122  PHE   A CE2 1 
ATOM   879  C  CZ  . PHE   A 1 121 ? -21.822 -47.633  -16.999 1.00 61.47  ? 122  PHE   A CZ  1 
ATOM   880  N  N   . LEU   A 1 122 ? -23.648 -52.213  -19.296 1.00 55.97  ? 123  LEU   A N   1 
ATOM   881  C  CA  . LEU   A 1 122 ? -23.369 -52.555  -20.715 1.00 55.30  ? 123  LEU   A CA  1 
ATOM   882  C  C   . LEU   A 1 122 ? -22.225 -51.682  -21.238 1.00 53.97  ? 123  LEU   A C   1 
ATOM   883  O  O   . LEU   A 1 122 ? -22.291 -50.458  -21.045 1.00 53.27  ? 123  LEU   A O   1 
ATOM   884  C  CB  . LEU   A 1 122 ? -24.639 -52.341  -21.543 1.00 56.90  ? 123  LEU   A CB  1 
ATOM   885  C  CG  . LEU   A 1 122 ? -25.640 -53.494  -21.522 1.00 58.63  ? 123  LEU   A CG  1 
ATOM   886  C  CD1 . LEU   A 1 122 ? -27.050 -52.986  -21.781 1.00 62.23  ? 123  LEU   A CD1 1 
ATOM   887  C  CD2 . LEU   A 1 122 ? -25.267 -54.566  -22.538 1.00 56.88  ? 123  LEU   A CD2 1 
ATOM   888  N  N   . LEU   A 1 123 ? -21.222 -52.304  -21.866 1.00 56.67  ? 124  LEU   A N   1 
ATOM   889  C  CA  . LEU   A 1 123 ? -20.134 -51.620  -22.618 1.00 55.28  ? 124  LEU   A CA  1 
ATOM   890  C  C   . LEU   A 1 123 ? -20.048 -52.236  -24.010 1.00 55.35  ? 124  LEU   A C   1 
ATOM   891  O  O   . LEU   A 1 123 ? -20.137 -53.451  -24.154 1.00 53.69  ? 124  LEU   A O   1 
ATOM   892  C  CB  . LEU   A 1 123 ? -18.806 -51.775  -21.870 1.00 56.61  ? 124  LEU   A CB  1 
ATOM   893  C  CG  . LEU   A 1 123 ? -18.748 -51.142  -20.481 1.00 56.98  ? 124  LEU   A CG  1 
ATOM   894  C  CD1 . LEU   A 1 123 ? -19.159 -52.138  -19.410 1.00 57.42  ? 124  LEU   A CD1 1 
ATOM   895  C  CD2 . LEU   A 1 123 ? -17.355 -50.612  -20.186 1.00 57.57  ? 124  LEU   A CD2 1 
ATOM   896  N  N   . PRO   A 1 124 ? -19.888 -51.430  -25.084 1.00 57.17  ? 125  PRO   A N   1 
ATOM   897  C  CA  . PRO   A 1 124 ? -19.788 -51.975  -26.436 1.00 56.11  ? 125  PRO   A CA  1 
ATOM   898  C  C   . PRO   A 1 124 ? -18.367 -52.396  -26.834 1.00 54.10  ? 125  PRO   A C   1 
ATOM   899  O  O   . PRO   A 1 124 ? -17.430 -51.729  -26.450 1.00 50.19  ? 125  PRO   A O   1 
ATOM   900  C  CB  . PRO   A 1 124 ? -20.230 -50.781  -27.291 1.00 56.00  ? 125  PRO   A CB  1 
ATOM   901  C  CG  . PRO   A 1 124 ? -19.684 -49.588  -26.539 1.00 55.64  ? 125  PRO   A CG  1 
ATOM   902  C  CD  . PRO   A 1 124 ? -19.805 -49.960  -25.071 1.00 56.00  ? 125  PRO   A CD  1 
ATOM   903  N  N   . LEU   A 1 125 ? -18.268 -53.505  -27.569 1.00 56.27  ? 126  LEU   A N   1 
ATOM   904  C  CA  . LEU   A 1 125 ? -17.141 -53.836  -28.475 1.00 58.27  ? 126  LEU   A CA  1 
ATOM   905  C  C   . LEU   A 1 125 ? -17.627 -53.619  -29.913 1.00 58.56  ? 126  LEU   A C   1 
ATOM   906  O  O   . LEU   A 1 125 ? -18.303 -54.514  -30.452 1.00 57.03  ? 126  LEU   A O   1 
ATOM   907  C  CB  . LEU   A 1 125 ? -16.706 -55.288  -28.247 1.00 61.90  ? 126  LEU   A CB  1 
ATOM   908  C  CG  . LEU   A 1 125 ? -16.305 -55.658  -26.821 1.00 61.37  ? 126  LEU   A CG  1 
ATOM   909  C  CD1 . LEU   A 1 125 ? -15.847 -57.105  -26.761 1.00 64.42  ? 126  LEU   A CD1 1 
ATOM   910  C  CD2 . LEU   A 1 125 ? -15.210 -54.742  -26.299 1.00 62.03  ? 126  LEU   A CD2 1 
ATOM   911  N  N   . ASN   A 1 126 ? -17.329 -52.452  -30.488 1.00 61.22  ? 127  ASN   A N   1 
ATOM   912  C  CA  . ASN   A 1 126 ? -17.830 -52.023  -31.821 1.00 59.72  ? 127  ASN   A CA  1 
ATOM   913  C  C   . ASN   A 1 126 ? -16.655 -51.763  -32.772 1.00 58.42  ? 127  ASN   A C   1 
ATOM   914  O  O   . ASN   A 1 126 ? -16.903 -51.251  -33.877 1.00 61.33  ? 127  ASN   A O   1 
ATOM   915  C  CB  . ASN   A 1 126 ? -18.741 -50.799  -31.692 1.00 59.32  ? 127  ASN   A CB  1 
ATOM   916  C  CG  . ASN   A 1 126 ? -18.030 -49.581  -31.140 1.00 62.83  ? 127  ASN   A CG  1 
ATOM   917  O  OD1 . ASN   A 1 126 ? -16.810 -49.462  -31.240 1.00 63.65  ? 127  ASN   A OD1 1 
ATOM   918  N  ND2 . ASN   A 1 126 ? -18.784 -48.666  -30.556 1.00 65.75  ? 127  ASN   A ND2 1 
ATOM   919  N  N   . GLN   A 1 127 ? -15.426 -52.079  -32.355 1.00 57.78  ? 128  GLN   A N   1 
ATOM   920  C  CA  . GLN   A 1 127 ? -14.208 -51.980  -33.204 1.00 59.42  ? 128  GLN   A CA  1 
ATOM   921  C  C   . GLN   A 1 127 ? -13.214 -53.048  -32.736 1.00 60.49  ? 128  GLN   A C   1 
ATOM   922  O  O   . GLN   A 1 127 ? -13.546 -53.772  -31.780 1.00 58.26  ? 128  GLN   A O   1 
ATOM   923  C  CB  . GLN   A 1 127 ? -13.631 -50.558  -33.183 1.00 59.36  ? 128  GLN   A CB  1 
ATOM   924  C  CG  . GLN   A 1 127 ? -13.471 -49.961  -31.792 1.00 62.00  ? 128  GLN   A CG  1 
ATOM   925  C  CD  . GLN   A 1 127 ? -12.765 -48.627  -31.817 1.00 64.71  ? 128  GLN   A CD  1 
ATOM   926  O  OE1 . GLN   A 1 127 ? -11.592 -48.521  -31.463 1.00 68.09  ? 128  GLN   A OE1 1 
ATOM   927  N  NE2 . GLN   A 1 127 ? -13.472 -47.591  -32.243 1.00 64.26  ? 128  GLN   A NE2 1 
ATOM   928  N  N   . GLU   A 1 128 ? -12.056 -53.150  -33.399 1.00 61.28  ? 129  GLU   A N   1 
ATOM   929  C  CA  . GLU   A 1 128 ? -11.035 -54.201  -33.154 1.00 60.16  ? 129  GLU   A CA  1 
ATOM   930  C  C   . GLU   A 1 128 ? -10.169 -53.829  -31.942 1.00 58.87  ? 129  GLU   A C   1 
ATOM   931  O  O   . GLU   A 1 128 ? -9.813  -54.743  -31.183 1.00 64.23  ? 129  GLU   A O   1 
ATOM   932  C  CB  . GLU   A 1 128 ? -10.177 -54.408  -34.403 1.00 61.62  ? 129  GLU   A CB  1 
ATOM   933  C  CG  . GLU   A 1 128 ? -9.217  -55.580  -34.297 1.00 62.09  ? 129  GLU   A CG  1 
ATOM   934  C  CD  . GLU   A 1 128 ? -8.246  -55.708  -35.456 1.00 63.94  ? 129  GLU   A CD  1 
ATOM   935  O  OE1 . GLU   A 1 128 ? -7.083  -56.067  -35.205 1.00 71.36  ? 129  GLU   A OE1 1 
ATOM   936  O  OE2 . GLU   A 1 128 ? -8.653  -55.452  -36.606 1.00 64.05  ? 129  GLU   A OE2 1 
ATOM   937  N  N   . ASP   A 1 129 ? -9.820  -52.552  -31.770 1.00 56.92  ? 130  ASP   A N   1 
ATOM   938  C  CA  . ASP   A 1 129 ? -8.899  -52.111  -30.687 1.00 55.24  ? 130  ASP   A CA  1 
ATOM   939  C  C   . ASP   A 1 129 ? -9.706  -51.541  -29.515 1.00 56.19  ? 130  ASP   A C   1 
ATOM   940  O  O   . ASP   A 1 129 ? -10.211 -50.406  -29.627 1.00 56.80  ? 130  ASP   A O   1 
ATOM   941  C  CB  . ASP   A 1 129 ? -7.867  -51.108  -31.199 1.00 52.47  ? 130  ASP   A CB  1 
ATOM   942  C  CG  . ASP   A 1 129 ? -6.790  -50.787  -30.183 1.00 51.76  ? 130  ASP   A CG  1 
ATOM   943  O  OD1 . ASP   A 1 129 ? -6.804  -51.394  -29.096 1.00 48.57  ? 130  ASP   A OD1 1 
ATOM   944  O  OD2 . ASP   A 1 129 ? -5.941  -49.932  -30.490 1.00 57.85  ? 130  ASP   A OD2 1 
ATOM   945  N  N   . ASN   A 1 130 ? -9.795  -52.303  -28.422 1.00 56.06  ? 131  ASN   A N   1 
ATOM   946  C  CA  . ASN   A 1 130 ? -10.446 -51.877  -27.155 1.00 53.65  ? 131  ASN   A CA  1 
ATOM   947  C  C   . ASN   A 1 130 ? -9.437  -52.034  -26.015 1.00 52.27  ? 131  ASN   A C   1 
ATOM   948  O  O   . ASN   A 1 130 ? -9.858  -52.245  -24.867 1.00 53.46  ? 131  ASN   A O   1 
ATOM   949  C  CB  . ASN   A 1 130 ? -11.753 -52.639  -26.951 1.00 53.84  ? 131  ASN   A CB  1 
ATOM   950  C  CG  . ASN   A 1 130 ? -12.721 -52.369  -28.084 1.00 54.09  ? 131  ASN   A CG  1 
ATOM   951  O  OD1 . ASN   A 1 130 ? -13.134 -51.228  -28.293 1.00 53.81  ? 131  ASN   A OD1 1 
ATOM   952  N  ND2 . ASN   A 1 130 ? -13.064 -53.401  -28.835 1.00 54.00  ? 131  ASN   A ND2 1 
ATOM   953  N  N   . THR   A 1 131 ? -8.148  -51.893  -26.328 1.00 50.92  ? 132  THR   A N   1 
ATOM   954  C  CA  . THR   A 1 131 ? -7.030  -52.144  -25.386 1.00 52.81  ? 132  THR   A CA  1 
ATOM   955  C  C   . THR   A 1 131 ? -7.150  -51.181  -24.198 1.00 53.25  ? 132  THR   A C   1 
ATOM   956  O  O   . THR   A 1 131 ? -7.032  -51.641  -23.045 1.00 53.88  ? 132  THR   A O   1 
ATOM   957  C  CB  . THR   A 1 131 ? -5.680  -52.062  -26.107 1.00 53.01  ? 132  THR   A CB  1 
ATOM   958  O  OG1 . THR   A 1 131 ? -5.698  -52.992  -27.191 1.00 52.23  ? 132  THR   A OG1 1 
ATOM   959  C  CG2 . THR   A 1 131 ? -4.514  -52.375  -25.197 1.00 53.23  ? 132  THR   A CG2 1 
ATOM   960  N  N   . ASN   A 1 132 ? -7.372  -49.895  -24.460 1.00 53.00  ? 133  ASN   A N   1 
ATOM   961  C  CA  . ASN   A 1 132 ? -7.492  -48.883  -23.380 1.00 54.28  ? 133  ASN   A CA  1 
ATOM   962  C  C   . ASN   A 1 132 ? -8.814  -49.093  -22.630 1.00 52.28  ? 133  ASN   A C   1 
ATOM   963  O  O   . ASN   A 1 132 ? -8.806  -48.954  -21.394 1.00 53.77  ? 133  ASN   A O   1 
ATOM   964  C  CB  . ASN   A 1 132 ? -7.356  -47.448  -23.887 1.00 54.78  ? 133  ASN   A CB  1 
ATOM   965  C  CG  . ASN   A 1 132 ? -7.000  -46.496  -22.764 1.00 54.20  ? 133  ASN   A CG  1 
ATOM   966  O  OD1 . ASN   A 1 132 ? -6.236  -46.852  -21.869 1.00 50.97  ? 133  ASN   A OD1 1 
ATOM   967  N  ND2 . ASN   A 1 132 ? -7.560  -45.297  -22.788 1.00 54.48  ? 133  ASN   A ND2 1 
ATOM   968  N  N   . LEU   A 1 133 ? -9.900  -49.408  -23.340 1.00 51.57  ? 134  LEU   A N   1 
ATOM   969  C  CA  . LEU   A 1 133 ? -11.231 -49.690  -22.732 1.00 53.16  ? 134  LEU   A CA  1 
ATOM   970  C  C   . LEU   A 1 133 ? -11.068 -50.805  -21.688 1.00 54.72  ? 134  LEU   A C   1 
ATOM   971  O  O   . LEU   A 1 133 ? -11.526 -50.617  -20.539 1.00 52.34  ? 134  LEU   A O   1 
ATOM   972  C  CB  . LEU   A 1 133 ? -12.221 -50.079  -23.836 1.00 54.00  ? 134  LEU   A CB  1 
ATOM   973  C  CG  . LEU   A 1 133 ? -13.637 -50.438  -23.383 1.00 55.73  ? 134  LEU   A CG  1 
ATOM   974  C  CD1 . LEU   A 1 133 ? -14.389 -49.211  -22.915 1.00 55.29  ? 134  LEU   A CD1 1 
ATOM   975  C  CD2 . LEU   A 1 133 ? -14.406 -51.113  -24.507 1.00 61.14  ? 134  LEU   A CD2 1 
ATOM   976  N  N   . ALA   A 1 134 ? -10.403 -51.901  -22.073 1.00 56.95  ? 135  ALA   A N   1 
ATOM   977  C  CA  . ALA   A 1 134 ? -10.090 -53.069  -21.216 1.00 55.70  ? 135  ALA   A CA  1 
ATOM   978  C  C   . ALA   A 1 134 ? -9.251  -52.629  -20.011 1.00 54.66  ? 135  ALA   A C   1 
ATOM   979  O  O   . ALA   A 1 134 ? -9.557  -53.059  -18.889 1.00 54.16  ? 135  ALA   A O   1 
ATOM   980  C  CB  . ALA   A 1 134 ? -9.369  -54.121  -22.019 1.00 57.36  ? 135  ALA   A CB  1 
ATOM   981  N  N   . ARG   A 1 135 ? -8.222  -51.811  -20.225 1.00 54.27  ? 136  ARG   A N   1 
ATOM   982  C  CA  . ARG   A 1 135 ? -7.333  -51.375  -19.121 1.00 56.59  ? 136  ARG   A CA  1 
ATOM   983  C  C   . ARG   A 1 135 ? -8.175  -50.651  -18.070 1.00 55.48  ? 136  ARG   A C   1 
ATOM   984  O  O   . ARG   A 1 135 ? -8.024  -50.970  -16.878 1.00 57.70  ? 136  ARG   A O   1 
ATOM   985  C  CB  . ARG   A 1 135 ? -6.203  -50.470  -19.609 1.00 60.43  ? 136  ARG   A CB  1 
ATOM   986  C  CG  . ARG   A 1 135 ? -5.225  -50.115  -18.500 1.00 64.80  ? 136  ARG   A CG  1 
ATOM   987  C  CD  . ARG   A 1 135 ? -4.453  -48.857  -18.805 1.00 71.76  ? 136  ARG   A CD  1 
ATOM   988  N  NE  . ARG   A 1 135 ? -5.114  -47.635  -18.370 1.00 77.41  ? 136  ARG   A NE  1 
ATOM   989  C  CZ  . ARG   A 1 135 ? -5.211  -47.223  -17.108 1.00 84.46  ? 136  ARG   A CZ  1 
ATOM   990  N  NH1 . ARG   A 1 135 ? -5.830  -46.084  -16.840 1.00 87.66  ? 136  ARG   A NH1 1 
ATOM   991  N  NH2 . ARG   A 1 135 ? -4.706  -47.945  -16.118 1.00 84.00  ? 136  ARG   A NH2 1 
ATOM   992  N  N   . VAL   A 1 136 ? -9.028  -49.720  -18.501 1.00 55.32  ? 137  VAL   A N   1 
ATOM   993  C  CA  . VAL   A 1 136 ? -9.876  -48.901  -17.588 1.00 55.20  ? 137  VAL   A CA  1 
ATOM   994  C  C   . VAL   A 1 136 ? -10.883 -49.824  -16.885 1.00 53.99  ? 137  VAL   A C   1 
ATOM   995  O  O   . VAL   A 1 136 ? -11.017 -49.697  -15.658 1.00 56.12  ? 137  VAL   A O   1 
ATOM   996  C  CB  . VAL   A 1 136 ? -10.553 -47.737  -18.336 1.00 58.19  ? 137  VAL   A CB  1 
ATOM   997  C  CG1 . VAL   A 1 136 ? -11.578 -47.018  -17.468 1.00 60.74  ? 137  VAL   A CG1 1 
ATOM   998  C  CG2 . VAL   A 1 136 ? -9.527  -46.747  -18.866 1.00 57.60  ? 137  VAL   A CG2 1 
ATOM   999  N  N   . LEU   A 1 137 ? -11.550 -50.734  -17.605 1.00 51.11  ? 138  LEU   A N   1 
ATOM   1000 C  CA  . LEU   A 1 137 ? -12.517 -51.673  -16.977 1.00 52.99  ? 138  LEU   A CA  1 
ATOM   1001 C  C   . LEU   A 1 137 ? -11.770 -52.534  -15.953 1.00 55.82  ? 138  LEU   A C   1 
ATOM   1002 O  O   . LEU   A 1 137 ? -12.258 -52.629  -14.809 1.00 56.84  ? 138  LEU   A O   1 
ATOM   1003 C  CB  . LEU   A 1 137 ? -13.218 -52.549  -18.023 1.00 52.77  ? 138  LEU   A CB  1 
ATOM   1004 C  CG  . LEU   A 1 137 ? -14.233 -53.546  -17.449 1.00 51.65  ? 138  LEU   A CG  1 
ATOM   1005 C  CD1 . LEU   A 1 137 ? -15.323 -52.837  -16.657 1.00 52.12  ? 138  LEU   A CD1 1 
ATOM   1006 C  CD2 . LEU   A 1 137 ? -14.855 -54.399  -18.541 1.00 50.77  ? 138  LEU   A CD2 1 
ATOM   1007 N  N   . THR   A 1 138 ? -10.634 -53.127  -16.342 1.00 57.16  ? 139  THR   A N   1 
ATOM   1008 C  CA  . THR   A 1 138 ? -9.788  -53.967  -15.450 1.00 59.18  ? 139  THR   A CA  1 
ATOM   1009 C  C   . THR   A 1 138 ? -9.462  -53.172  -14.184 1.00 59.43  ? 139  THR   A C   1 
ATOM   1010 O  O   . THR   A 1 138 ? -9.636  -53.729  -13.087 1.00 64.64  ? 139  THR   A O   1 
ATOM   1011 C  CB  . THR   A 1 138 ? -8.501  -54.466  -16.123 1.00 60.74  ? 139  THR   A CB  1 
ATOM   1012 O  OG1 . THR   A 1 138 ? -8.839  -55.229  -17.280 1.00 63.81  ? 139  THR   A OG1 1 
ATOM   1013 C  CG2 . THR   A 1 138 ? -7.669  -55.342  -15.211 1.00 62.60  ? 139  THR   A CG2 1 
ATOM   1014 N  N   . ASN   A 1 139 ? -9.031  -51.917  -14.331 1.00 59.48  ? 140  ASN   A N   1 
ATOM   1015 C  CA  . ASN   A 1 139 ? -8.659  -51.050  -13.182 1.00 61.33  ? 140  ASN   A CA  1 
ATOM   1016 C  C   . ASN   A 1 139 ? -9.892  -50.882  -12.287 1.00 59.25  ? 140  ASN   A C   1 
ATOM   1017 O  O   . ASN   A 1 139 ? -9.734  -50.956  -11.061 1.00 60.73  ? 140  ASN   A O   1 
ATOM   1018 C  CB  . ASN   A 1 139 ? -8.052  -49.718  -13.633 1.00 64.99  ? 140  ASN   A CB  1 
ATOM   1019 C  CG  . ASN   A 1 139 ? -6.573  -49.813  -13.956 1.00 70.06  ? 140  ASN   A CG  1 
ATOM   1020 O  OD1 . ASN   A 1 139 ? -5.808  -48.910  -13.625 1.00 79.56  ? 140  ASN   A OD1 1 
ATOM   1021 N  ND2 . ASN   A 1 139 ? -6.152  -50.892  -14.599 1.00 69.68  ? 140  ASN   A ND2 1 
ATOM   1022 N  N   . HIS   A 1 140 ? -11.078 -50.708  -12.878 1.00 57.74  ? 141  HIS   A N   1 
ATOM   1023 C  CA  . HIS   A 1 140 ? -12.357 -50.548  -12.137 1.00 55.06  ? 141  HIS   A CA  1 
ATOM   1024 C  C   . HIS   A 1 140 ? -12.685 -51.830  -11.363 1.00 54.90  ? 141  HIS   A C   1 
ATOM   1025 O  O   . HIS   A 1 140 ? -13.079 -51.726  -10.184 1.00 54.24  ? 141  HIS   A O   1 
ATOM   1026 C  CB  . HIS   A 1 140 ? -13.507 -50.160  -13.071 1.00 53.07  ? 141  HIS   A CB  1 
ATOM   1027 C  CG  . HIS   A 1 140 ? -14.819 -50.159  -12.367 1.00 50.53  ? 141  HIS   A CG  1 
ATOM   1028 N  ND1 . HIS   A 1 140 ? -15.167 -49.171  -11.468 1.00 47.22  ? 141  HIS   A ND1 1 
ATOM   1029 C  CD2 . HIS   A 1 140 ? -15.836 -51.046  -12.378 1.00 48.63  ? 141  HIS   A CD2 1 
ATOM   1030 C  CE1 . HIS   A 1 140 ? -16.358 -49.440  -10.971 1.00 49.30  ? 141  HIS   A CE1 1 
ATOM   1031 N  NE2 . HIS   A 1 140 ? -16.789 -50.589  -11.510 1.00 48.17  ? 141  HIS   A NE2 1 
ATOM   1032 N  N   . ILE   A 1 141 ? -12.547 -52.990  -12.005 1.00 57.03  ? 142  ILE   A N   1 
ATOM   1033 C  CA  . ILE   A 1 141 ? -12.826 -54.322  -11.387 1.00 59.95  ? 142  ILE   A CA  1 
ATOM   1034 C  C   . ILE   A 1 141 ? -11.931 -54.506  -10.153 1.00 63.84  ? 142  ILE   A C   1 
ATOM   1035 O  O   . ILE   A 1 141 ? -12.433 -55.045  -9.152  1.00 65.87  ? 142  ILE   A O   1 
ATOM   1036 C  CB  . ILE   A 1 141 ? -12.654 -55.458  -12.414 1.00 58.47  ? 142  ILE   A CB  1 
ATOM   1037 C  CG1 . ILE   A 1 141 ? -13.809 -55.464  -13.418 1.00 57.37  ? 142  ILE   A CG1 1 
ATOM   1038 C  CG2 . ILE   A 1 141 ? -12.507 -56.804  -11.720 1.00 59.91  ? 142  ILE   A CG2 1 
ATOM   1039 C  CD1 . ILE   A 1 141 ? -13.534 -56.244  -14.676 1.00 56.83  ? 142  ILE   A CD1 1 
ATOM   1040 N  N   . HIS   A 1 142 ? -10.677 -54.043  -10.212 1.00 65.81  ? 143  HIS   A N   1 
ATOM   1041 C  CA  . HIS   A 1 142 ? -9.655  -54.204  -9.142  1.00 68.14  ? 143  HIS   A CA  1 
ATOM   1042 C  C   . HIS   A 1 142 ? -9.665  -53.003  -8.187  1.00 72.06  ? 143  HIS   A C   1 
ATOM   1043 O  O   . HIS   A 1 142 ? -8.634  -52.787  -7.523  1.00 76.27  ? 143  HIS   A O   1 
ATOM   1044 C  CB  . HIS   A 1 142 ? -8.270  -54.424  -9.763  1.00 71.09  ? 143  HIS   A CB  1 
ATOM   1045 C  CG  . HIS   A 1 142 ? -8.122  -55.744  -10.440 1.00 76.56  ? 143  HIS   A CG  1 
ATOM   1046 N  ND1 . HIS   A 1 142 ? -8.633  -55.995  -11.699 1.00 77.91  ? 143  HIS   A ND1 1 
ATOM   1047 C  CD2 . HIS   A 1 142 ? -7.524  -56.887  -10.040 1.00 80.83  ? 143  HIS   A CD2 1 
ATOM   1048 C  CE1 . HIS   A 1 142 ? -8.354  -57.235  -12.046 1.00 81.06  ? 143  HIS   A CE1 1 
ATOM   1049 N  NE2 . HIS   A 1 142 ? -7.674  -57.804  -11.045 1.00 81.29  ? 143  HIS   A NE2 1 
ATOM   1050 N  N   . THR   A 1 143 ? -10.782 -52.268  -8.106  1.00 77.17  ? 144  THR   A N   1 
ATOM   1051 C  CA  . THR   A 1 143 ? -11.000 -51.124  -7.175  1.00 80.94  ? 144  THR   A CA  1 
ATOM   1052 C  C   . THR   A 1 143 ? -12.272 -51.391  -6.356  1.00 88.94  ? 144  THR   A C   1 
ATOM   1053 O  O   . THR   A 1 143 ? -13.339 -50.848  -6.720  1.00 90.90  ? 144  THR   A O   1 
ATOM   1054 C  CB  . THR   A 1 143 ? -11.057 -49.793  -7.938  1.00 77.81  ? 144  THR   A CB  1 
ATOM   1055 O  OG1 . THR   A 1 143 ? -9.872  -49.694  -8.728  1.00 75.39  ? 144  THR   A OG1 1 
ATOM   1056 C  CG2 . THR   A 1 143 ? -11.158 -48.583  -7.034  1.00 75.71  ? 144  THR   A CG2 1 
ATOM   1057 N  N   . GLY   A 1 144 ? -12.145 -52.188  -5.288  1.00 94.04  ? 145  GLY   A N   1 
ATOM   1058 C  CA  . GLY   A 1 144 ? -13.263 -52.713  -4.479  1.00 97.73  ? 145  GLY   A CA  1 
ATOM   1059 C  C   . GLY   A 1 144 ? -13.496 -54.185  -4.773  1.00 104.73 ? 145  GLY   A C   1 
ATOM   1060 O  O   . GLY   A 1 144 ? -12.956 -54.672  -5.789  1.00 106.46 ? 145  GLY   A O   1 
ATOM   1061 N  N   . HIS   A 1 145 ? -14.262 -54.872  -3.919  1.00 110.03 ? 146  HIS   A N   1 
ATOM   1062 C  CA  . HIS   A 1 145 ? -14.618 -56.311  -4.055  1.00 115.74 ? 146  HIS   A CA  1 
ATOM   1063 C  C   . HIS   A 1 145 ? -16.114 -56.434  -4.382  1.00 110.38 ? 146  HIS   A C   1 
ATOM   1064 O  O   . HIS   A 1 145 ? -16.845 -57.050  -3.584  1.00 113.23 ? 146  HIS   A O   1 
ATOM   1065 C  CB  . HIS   A 1 145 ? -14.198 -57.089  -2.794  1.00 123.83 ? 146  HIS   A CB  1 
ATOM   1066 C  CG  . HIS   A 1 145 ? -12.855 -57.737  -2.896  1.00 131.29 ? 146  HIS   A CG  1 
ATOM   1067 N  ND1 . HIS   A 1 145 ? -12.701 -59.065  -3.255  1.00 134.14 ? 146  HIS   A ND1 1 
ATOM   1068 C  CD2 . HIS   A 1 145 ? -11.609 -57.256  -2.688  1.00 134.78 ? 146  HIS   A CD2 1 
ATOM   1069 C  CE1 . HIS   A 1 145 ? -11.418 -59.371  -3.265  1.00 133.22 ? 146  HIS   A CE1 1 
ATOM   1070 N  NE2 . HIS   A 1 145 ? -10.726 -58.277  -2.922  1.00 130.64 ? 146  HIS   A NE2 1 
ATOM   1071 N  N   . HIS   A 1 146 ? -16.542 -55.868  -5.518  1.00 105.47 ? 147  HIS   A N   1 
ATOM   1072 C  CA  . HIS   A 1 146 ? -17.940 -55.919  -6.033  1.00 100.64 ? 147  HIS   A CA  1 
ATOM   1073 C  C   . HIS   A 1 146 ? -18.119 -57.159  -6.917  1.00 92.93  ? 147  HIS   A C   1 
ATOM   1074 O  O   . HIS   A 1 146 ? -17.109 -57.655  -7.455  1.00 89.49  ? 147  HIS   A O   1 
ATOM   1075 C  CB  . HIS   A 1 146 ? -18.301 -54.629  -6.787  1.00 101.81 ? 147  HIS   A CB  1 
ATOM   1076 C  CG  . HIS   A 1 146 ? -17.963 -53.379  -6.046  1.00 104.68 ? 147  HIS   A CG  1 
ATOM   1077 N  ND1 . HIS   A 1 146 ? -17.117 -52.418  -6.569  1.00 103.57 ? 147  HIS   A ND1 1 
ATOM   1078 C  CD2 . HIS   A 1 146 ? -18.338 -52.935  -4.828  1.00 106.82 ? 147  HIS   A CD2 1 
ATOM   1079 C  CE1 . HIS   A 1 146 ? -16.992 -51.433  -5.705  1.00 107.83 ? 147  HIS   A CE1 1 
ATOM   1080 N  NE2 . HIS   A 1 146 ? -17.728 -51.727  -4.626  1.00 109.60 ? 147  HIS   A NE2 1 
ATOM   1081 N  N   . SER   A 1 147 ? -19.361 -57.637  -7.049  1.00 87.54  ? 148  SER   A N   1 
ATOM   1082 C  CA  . SER   A 1 147 ? -19.753 -58.832  -7.845  1.00 84.77  ? 148  SER   A CA  1 
ATOM   1083 C  C   . SER   A 1 147 ? -20.578 -58.428  -9.079  1.00 81.60  ? 148  SER   A C   1 
ATOM   1084 O  O   . SER   A 1 147 ? -20.926 -59.331  -9.870  1.00 77.95  ? 148  SER   A O   1 
ATOM   1085 C  CB  . SER   A 1 147 ? -20.505 -59.805  -6.978  1.00 84.71  ? 148  SER   A CB  1 
ATOM   1086 O  OG  . SER   A 1 147 ? -21.632 -59.179  -6.381  1.00 88.48  ? 148  SER   A OG  1 
ATOM   1087 N  N   . SER   A 1 148 ? -20.881 -57.130  -9.226  1.00 75.05  ? 149  SER   A N   1 
ATOM   1088 C  CA  . SER   A 1 148 ? -21.589 -56.510  -10.380 1.00 70.24  ? 149  SER   A CA  1 
ATOM   1089 C  C   . SER   A 1 148 ? -21.045 -57.058  -11.707 1.00 66.89  ? 149  SER   A C   1 
ATOM   1090 O  O   . SER   A 1 148 ? -19.811 -57.172  -11.831 1.00 70.62  ? 149  SER   A O   1 
ATOM   1091 C  CB  . SER   A 1 148 ? -21.463 -55.008  -10.323 1.00 68.95  ? 149  SER   A CB  1 
ATOM   1092 O  OG  . SER   A 1 148 ? -21.546 -54.448  -11.621 1.00 73.32  ? 149  SER   A OG  1 
ATOM   1093 N  N   . MET   A 1 149 ? -21.929 -57.357  -12.665 1.00 61.16  ? 150  MET   A N   1 
ATOM   1094 C  CA  . MET   A 1 149 ? -21.570 -57.957  -13.981 1.00 60.69  ? 150  MET   A CA  1 
ATOM   1095 C  C   . MET   A 1 149 ? -21.357 -56.861  -15.034 1.00 60.03  ? 150  MET   A C   1 
ATOM   1096 O  O   . MET   A 1 149 ? -21.984 -55.785  -14.935 1.00 60.95  ? 150  MET   A O   1 
ATOM   1097 C  CB  . MET   A 1 149 ? -22.659 -58.912  -14.478 1.00 60.51  ? 150  MET   A CB  1 
ATOM   1098 C  CG  . MET   A 1 149 ? -22.737 -60.214  -13.701 1.00 62.67  ? 150  MET   A CG  1 
ATOM   1099 S  SD  . MET   A 1 149 ? -21.197 -61.172  -13.737 1.00 61.52  ? 150  MET   A SD  1 
ATOM   1100 C  CE  . MET   A 1 149 ? -21.094 -61.577  -15.479 1.00 61.73  ? 150  MET   A CE  1 
ATOM   1101 N  N   . PHE   A 1 150 ? -20.496 -57.145  -16.011 1.00 56.45  ? 151  PHE   A N   1 
ATOM   1102 C  CA  . PHE   A 1 150 ? -20.234 -56.288  -17.193 1.00 54.16  ? 151  PHE   A CA  1 
ATOM   1103 C  C   . PHE   A 1 150 ? -20.612 -57.076  -18.448 1.00 52.82  ? 151  PHE   A C   1 
ATOM   1104 O  O   . PHE   A 1 150 ? -20.016 -58.141  -18.710 1.00 49.01  ? 151  PHE   A O   1 
ATOM   1105 C  CB  . PHE   A 1 150 ? -18.788 -55.796  -17.170 1.00 53.64  ? 151  PHE   A CB  1 
ATOM   1106 C  CG  . PHE   A 1 150 ? -18.479 -55.002  -15.930 1.00 54.42  ? 151  PHE   A CG  1 
ATOM   1107 C  CD1 . PHE   A 1 150 ? -18.949 -53.705  -15.792 1.00 53.94  ? 151  PHE   A CD1 1 
ATOM   1108 C  CD2 . PHE   A 1 150 ? -17.773 -55.569  -14.880 1.00 54.89  ? 151  PHE   A CD2 1 
ATOM   1109 C  CE1 . PHE   A 1 150 ? -18.690 -52.980  -14.641 1.00 54.39  ? 151  PHE   A CE1 1 
ATOM   1110 C  CE2 . PHE   A 1 150 ? -17.506 -54.838  -13.733 1.00 55.13  ? 151  PHE   A CE2 1 
ATOM   1111 C  CZ  . PHE   A 1 150 ? -17.970 -53.548  -13.614 1.00 55.67  ? 151  PHE   A CZ  1 
ATOM   1112 N  N   . TRP   A 1 151 ? -21.622 -56.570  -19.159 1.00 53.41  ? 152  TRP   A N   1 
ATOM   1113 C  CA  . TRP   A 1 151 ? -22.166 -57.147  -20.412 1.00 53.60  ? 152  TRP   A CA  1 
ATOM   1114 C  C   . TRP   A 1 151 ? -21.533 -56.418  -21.595 1.00 55.86  ? 152  TRP   A C   1 
ATOM   1115 O  O   . TRP   A 1 151 ? -21.878 -55.238  -21.817 1.00 55.41  ? 152  TRP   A O   1 
ATOM   1116 C  CB  . TRP   A 1 151 ? -23.693 -57.051  -20.422 1.00 55.16  ? 152  TRP   A CB  1 
ATOM   1117 C  CG  . TRP   A 1 151 ? -24.354 -57.910  -19.390 1.00 56.95  ? 152  TRP   A CG  1 
ATOM   1118 C  CD1 . TRP   A 1 151 ? -23.756 -58.808  -18.552 1.00 57.84  ? 152  TRP   A CD1 1 
ATOM   1119 C  CD2 . TRP   A 1 151 ? -25.763 -57.981  -19.109 1.00 58.40  ? 152  TRP   A CD2 1 
ATOM   1120 N  NE1 . TRP   A 1 151 ? -24.688 -59.413  -17.755 1.00 59.51  ? 152  TRP   A NE1 1 
ATOM   1121 C  CE2 . TRP   A 1 151 ? -25.930 -58.931  -18.076 1.00 61.43  ? 152  TRP   A CE2 1 
ATOM   1122 C  CE3 . TRP   A 1 151 ? -26.892 -57.328  -19.614 1.00 58.22  ? 152  TRP   A CE3 1 
ATOM   1123 C  CZ2 . TRP   A 1 151 ? -27.183 -59.246  -17.551 1.00 62.32  ? 152  TRP   A CZ2 1 
ATOM   1124 C  CZ3 . TRP   A 1 151 ? -28.129 -57.643  -19.097 1.00 60.37  ? 152  TRP   A CZ3 1 
ATOM   1125 C  CH2 . TRP   A 1 151 ? -28.272 -58.589  -18.080 1.00 60.94  ? 152  TRP   A CH2 1 
ATOM   1126 N  N   . MET   A 1 152 ? -20.605 -57.086  -22.287 1.00 55.24  ? 153  MET   A N   1 
ATOM   1127 C  CA  . MET   A 1 152 ? -19.932 -56.550  -23.496 1.00 54.44  ? 153  MET   A CA  1 
ATOM   1128 C  C   . MET   A 1 152 ? -20.895 -56.712  -24.676 1.00 56.75  ? 153  MET   A C   1 
ATOM   1129 O  O   . MET   A 1 152 ? -21.114 -57.863  -25.110 1.00 57.41  ? 153  MET   A O   1 
ATOM   1130 C  CB  . MET   A 1 152 ? -18.606 -57.267  -23.767 1.00 54.08  ? 153  MET   A CB  1 
ATOM   1131 C  CG  . MET   A 1 152 ? -17.679 -57.297  -22.559 1.00 53.33  ? 153  MET   A CG  1 
ATOM   1132 S  SD  . MET   A 1 152 ? -17.497 -55.684  -21.740 1.00 52.24  ? 153  MET   A SD  1 
ATOM   1133 C  CE  . MET   A 1 152 ? -16.954 -54.688  -23.127 1.00 49.72  ? 153  MET   A CE  1 
ATOM   1134 N  N   . ARG   A 1 153 ? -21.503 -55.602  -25.106 1.00 59.62  ? 154  ARG   A N   1 
ATOM   1135 C  CA  . ARG   A 1 153 ? -22.406 -55.524  -26.282 1.00 61.08  ? 154  ARG   A CA  1 
ATOM   1136 C  C   . ARG   A 1 153 ? -21.543 -55.692  -27.533 1.00 60.44  ? 154  ARG   A C   1 
ATOM   1137 O  O   . ARG   A 1 153 ? -20.825 -54.732  -27.892 1.00 58.52  ? 154  ARG   A O   1 
ATOM   1138 C  CB  . ARG   A 1 153 ? -23.164 -54.194  -26.284 1.00 66.35  ? 154  ARG   A CB  1 
ATOM   1139 C  CG  . ARG   A 1 153 ? -24.248 -54.073  -27.346 1.00 70.35  ? 154  ARG   A CG  1 
ATOM   1140 C  CD  . ARG   A 1 153 ? -25.006 -52.766  -27.189 1.00 74.94  ? 154  ARG   A CD  1 
ATOM   1141 N  NE  . ARG   A 1 153 ? -26.333 -52.827  -27.787 1.00 78.40  ? 154  ARG   A NE  1 
ATOM   1142 C  CZ  . ARG   A 1 153 ? -27.418 -52.208  -27.324 1.00 80.71  ? 154  ARG   A CZ  1 
ATOM   1143 N  NH1 . ARG   A 1 153 ? -27.363 -51.469  -26.226 1.00 80.46  ? 154  ARG   A NH1 1 
ATOM   1144 N  NH2 . ARG   A 1 153 ? -28.567 -52.345  -27.963 1.00 80.10  ? 154  ARG   A NH2 1 
ATOM   1145 N  N   . VAL   A 1 154 ? -21.574 -56.886  -28.129 1.00 57.00  ? 155  VAL   A N   1 
ATOM   1146 C  CA  . VAL   A 1 154 ? -20.762 -57.242  -29.327 1.00 57.95  ? 155  VAL   A CA  1 
ATOM   1147 C  C   . VAL   A 1 154 ? -21.694 -57.922  -30.327 1.00 58.21  ? 155  VAL   A C   1 
ATOM   1148 O  O   . VAL   A 1 154 ? -22.515 -58.755  -29.947 1.00 60.17  ? 155  VAL   A O   1 
ATOM   1149 C  CB  . VAL   A 1 154 ? -19.536 -58.099  -28.942 1.00 58.65  ? 155  VAL   A CB  1 
ATOM   1150 C  CG1 . VAL   A 1 154 ? -19.913 -59.349  -28.166 1.00 59.75  ? 155  VAL   A CG1 1 
ATOM   1151 C  CG2 . VAL   A 1 154 ? -18.685 -58.459  -30.147 1.00 60.74  ? 155  VAL   A CG2 1 
ATOM   1152 N  N   . PRO   A 1 155 ? -21.645 -57.538  -31.623 1.00 58.45  ? 156  PRO   A N   1 
ATOM   1153 C  CA  . PRO   A 1 155 ? -22.521 -58.126  -32.639 1.00 58.32  ? 156  PRO   A CA  1 
ATOM   1154 C  C   . PRO   A 1 155 ? -22.001 -59.424  -33.276 1.00 60.48  ? 156  PRO   A C   1 
ATOM   1155 O  O   . PRO   A 1 155 ? -20.793 -59.557  -33.416 1.00 58.65  ? 156  PRO   A O   1 
ATOM   1156 C  CB  . PRO   A 1 155 ? -22.550 -57.020  -33.699 1.00 58.05  ? 156  PRO   A CB  1 
ATOM   1157 C  CG  . PRO   A 1 155 ? -21.164 -56.416  -33.631 1.00 58.10  ? 156  PRO   A CG  1 
ATOM   1158 C  CD  . PRO   A 1 155 ? -20.782 -56.477  -32.167 1.00 57.92  ? 156  PRO   A CD  1 
ATOM   1159 N  N   . LEU   A 1 156 ? -22.914 -60.327  -33.664 1.00 61.43  ? 157  LEU   A N   1 
ATOM   1160 C  CA  . LEU   A 1 156 ? -22.597 -61.522  -34.498 1.00 62.96  ? 157  LEU   A CA  1 
ATOM   1161 C  C   . LEU   A 1 156 ? -21.861 -61.061  -35.759 1.00 62.28  ? 157  LEU   A C   1 
ATOM   1162 O  O   . LEU   A 1 156 ? -20.834 -61.672  -36.111 1.00 63.22  ? 157  LEU   A O   1 
ATOM   1163 C  CB  . LEU   A 1 156 ? -23.881 -62.267  -34.881 1.00 63.21  ? 157  LEU   A CB  1 
ATOM   1164 C  CG  . LEU   A 1 156 ? -24.356 -63.340  -33.904 1.00 67.41  ? 157  LEU   A CG  1 
ATOM   1165 C  CD1 . LEU   A 1 156 ? -25.672 -63.945  -34.375 1.00 67.22  ? 157  LEU   A CD1 1 
ATOM   1166 C  CD2 . LEU   A 1 156 ? -23.305 -64.428  -33.726 1.00 69.36  ? 157  LEU   A CD2 1 
ATOM   1167 N  N   . VAL   A 1 157 ? -22.386 -60.023  -36.411 1.00 62.09  ? 158  VAL   A N   1 
ATOM   1168 C  CA  . VAL   A 1 157 ? -21.830 -59.454  -37.671 1.00 62.70  ? 158  VAL   A CA  1 
ATOM   1169 C  C   . VAL   A 1 157 ? -21.431 -58.006  -37.386 1.00 60.40  ? 158  VAL   A C   1 
ATOM   1170 O  O   . VAL   A 1 157 ? -22.297 -57.236  -36.953 1.00 64.51  ? 158  VAL   A O   1 
ATOM   1171 C  CB  . VAL   A 1 157 ? -22.838 -59.565  -38.833 1.00 59.77  ? 158  VAL   A CB  1 
ATOM   1172 C  CG1 . VAL   A 1 157 ? -22.260 -59.044  -40.142 1.00 58.58  ? 158  VAL   A CG1 1 
ATOM   1173 C  CG2 . VAL   A 1 157 ? -23.338 -60.992  -39.005 1.00 59.05  ? 158  VAL   A CG2 1 
ATOM   1174 N  N   . ALA   A 1 158 ? -20.156 -57.675  -37.596 1.00 62.45  ? 159  ALA   A N   1 
ATOM   1175 C  CA  . ALA   A 1 158 ? -19.614 -56.301  -37.499 1.00 67.31  ? 159  ALA   A CA  1 
ATOM   1176 C  C   . ALA   A 1 158 ? -20.472 -55.383  -38.365 1.00 69.31  ? 159  ALA   A C   1 
ATOM   1177 O  O   . ALA   A 1 158 ? -20.892 -55.787  -39.447 1.00 70.42  ? 159  ALA   A O   1 
ATOM   1178 C  CB  . ALA   A 1 158 ? -18.165 -56.281  -37.929 1.00 67.99  ? 159  ALA   A CB  1 
ATOM   1179 N  N   . PRO   A 1 159 ? -20.765 -54.135  -37.928 1.00 74.64  ? 160  PRO   A N   1 
ATOM   1180 C  CA  . PRO   A 1 159 ? -21.641 -53.241  -38.691 1.00 76.64  ? 160  PRO   A CA  1 
ATOM   1181 C  C   . PRO   A 1 159 ? -21.135 -52.994  -40.122 1.00 74.51  ? 160  PRO   A C   1 
ATOM   1182 O  O   . PRO   A 1 159 ? -21.952 -52.934  -41.026 1.00 75.71  ? 160  PRO   A O   1 
ATOM   1183 C  CB  . PRO   A 1 159 ? -21.633 -51.930  -37.888 1.00 78.85  ? 160  PRO   A CB  1 
ATOM   1184 C  CG  . PRO   A 1 159 ? -21.185 -52.329  -36.494 1.00 78.72  ? 160  PRO   A CG  1 
ATOM   1185 C  CD  . PRO   A 1 159 ? -20.260 -53.511  -36.695 1.00 76.56  ? 160  PRO   A CD  1 
ATOM   1186 N  N   . GLU   A 1 160 ? -19.810 -52.884  -40.282 1.00 70.71  ? 161  GLU   A N   1 
ATOM   1187 C  CA  . GLU   A 1 160 ? -19.103 -52.719  -41.582 1.00 70.85  ? 161  GLU   A CA  1 
ATOM   1188 C  C   . GLU   A 1 160 ? -19.434 -53.879  -42.530 1.00 70.16  ? 161  GLU   A C   1 
ATOM   1189 O  O   . GLU   A 1 160 ? -19.415 -53.651  -43.750 1.00 71.43  ? 161  GLU   A O   1 
ATOM   1190 C  CB  . GLU   A 1 160 ? -17.591 -52.653  -41.353 1.00 70.89  ? 161  GLU   A CB  1 
ATOM   1191 C  CG  . GLU   A 1 160 ? -16.789 -52.386  -42.613 1.00 72.47  ? 161  GLU   A CG  1 
ATOM   1192 C  CD  . GLU   A 1 160 ? -17.116 -51.073  -43.306 1.00 75.12  ? 161  GLU   A CD  1 
ATOM   1193 O  OE1 . GLU   A 1 160 ? -17.116 -50.030  -42.622 1.00 73.74  ? 161  GLU   A OE1 1 
ATOM   1194 O  OE2 . GLU   A 1 160 ? -17.371 -51.094  -44.529 1.00 75.37  ? 161  GLU   A OE2 1 
ATOM   1195 N  N   . ASP   A 1 161 ? -19.708 -55.074  -41.997 1.00 69.04  ? 162  ASP   A N   1 
ATOM   1196 C  CA  . ASP   A 1 161 ? -19.939 -56.305  -42.798 1.00 71.31  ? 162  ASP   A CA  1 
ATOM   1197 C  C   . ASP   A 1 161 ? -21.439 -56.519  -43.056 1.00 71.75  ? 162  ASP   A C   1 
ATOM   1198 O  O   . ASP   A 1 161 ? -21.763 -57.541  -43.700 1.00 71.42  ? 162  ASP   A O   1 
ATOM   1199 C  CB  . ASP   A 1 161 ? -19.320 -57.533  -42.121 1.00 72.03  ? 162  ASP   A CB  1 
ATOM   1200 C  CG  . ASP   A 1 161 ? -17.816 -57.441  -41.911 1.00 72.90  ? 162  ASP   A CG  1 
ATOM   1201 O  OD1 . ASP   A 1 161 ? -17.163 -56.670  -42.639 1.00 73.37  ? 162  ASP   A OD1 1 
ATOM   1202 O  OD2 . ASP   A 1 161 ? -17.308 -58.139  -41.008 1.00 75.92  ? 162  ASP   A OD2 1 
ATOM   1203 N  N   . LEU   A 1 162 ? -22.323 -55.626  -42.585 1.00 70.99  ? 163  LEU   A N   1 
ATOM   1204 C  CA  . LEU   A 1 162 ? -23.782 -55.703  -42.895 1.00 74.99  ? 163  LEU   A CA  1 
ATOM   1205 C  C   . LEU   A 1 162 ? -24.312 -54.354  -43.401 1.00 73.06  ? 163  LEU   A C   1 
ATOM   1206 O  O   . LEU   A 1 162 ? -25.548 -54.196  -43.437 1.00 74.77  ? 163  LEU   A O   1 
ATOM   1207 C  CB  . LEU   A 1 162 ? -24.569 -56.205  -41.674 1.00 76.59  ? 163  LEU   A CB  1 
ATOM   1208 C  CG  . LEU   A 1 162 ? -24.423 -55.427  -40.365 1.00 80.69  ? 163  LEU   A CG  1 
ATOM   1209 C  CD1 . LEU   A 1 162 ? -25.085 -54.056  -40.434 1.00 82.59  ? 163  LEU   A CD1 1 
ATOM   1210 C  CD2 . LEU   A 1 162 ? -25.015 -56.227  -39.214 1.00 79.91  ? 163  LEU   A CD2 1 
ATOM   1211 N  N   . ARG   A 1 163 ? -23.434 -53.433  -43.813 1.00 71.67  ? 164  ARG   A N   1 
ATOM   1212 C  CA  . ARG   A 1 163 ? -23.841 -52.136  -44.416 1.00 70.40  ? 164  ARG   A CA  1 
ATOM   1213 C  C   . ARG   A 1 163 ? -24.428 -52.411  -45.804 1.00 70.73  ? 164  ARG   A C   1 
ATOM   1214 O  O   . ARG   A 1 163 ? -23.840 -53.227  -46.533 1.00 72.94  ? 164  ARG   A O   1 
ATOM   1215 C  CB  . ARG   A 1 163 ? -22.667 -51.153  -44.485 1.00 70.89  ? 164  ARG   A CB  1 
ATOM   1216 C  CG  . ARG   A 1 163 ? -21.587 -51.507  -45.498 1.00 71.27  ? 164  ARG   A CG  1 
ATOM   1217 C  CD  . ARG   A 1 163 ? -20.443 -50.512  -45.472 1.00 73.22  ? 164  ARG   A CD  1 
ATOM   1218 N  NE  . ARG   A 1 163 ? -19.417 -50.836  -46.455 1.00 76.59  ? 164  ARG   A NE  1 
ATOM   1219 C  CZ  . ARG   A 1 163 ? -19.519 -50.636  -47.769 1.00 79.24  ? 164  ARG   A CZ  1 
ATOM   1220 N  NH1 . ARG   A 1 163 ? -20.612 -50.103  -48.295 1.00 83.69  ? 164  ARG   A NH1 1 
ATOM   1221 N  NH2 . ARG   A 1 163 ? -18.520 -50.984  -48.561 1.00 77.27  ? 164  ARG   A NH2 1 
ATOM   1222 N  N   . ASP   A 1 164 ? -25.560 -51.776  -46.131 1.00 74.04  ? 165  ASP   A N   1 
ATOM   1223 C  CA  . ASP   A 1 164 ? -26.169 -51.787  -47.489 1.00 71.51  ? 165  ASP   A CA  1 
ATOM   1224 C  C   . ASP   A 1 164 ? -25.058 -51.504  -48.508 1.00 69.56  ? 165  ASP   A C   1 
ATOM   1225 O  O   . ASP   A 1 164 ? -24.177 -50.659  -48.208 1.00 68.60  ? 165  ASP   A O   1 
ATOM   1226 C  CB  . ASP   A 1 164 ? -27.302 -50.761  -47.616 1.00 70.67  ? 165  ASP   A CB  1 
ATOM   1227 C  CG  . ASP   A 1 164 ? -28.504 -51.013  -46.715 1.00 74.47  ? 165  ASP   A CG  1 
ATOM   1228 O  OD1 . ASP   A 1 164 ? -28.775 -52.191  -46.401 1.00 79.46  ? 165  ASP   A OD1 1 
ATOM   1229 O  OD2 . ASP   A 1 164 ? -29.168 -50.024  -46.339 1.00 75.19  ? 165  ASP   A OD2 1 
ATOM   1230 N  N   . ASP   A 1 165 ? -25.090 -52.189  -49.653 1.00 69.33  ? 166  ASP   A N   1 
ATOM   1231 C  CA  . ASP   A 1 165 ? -24.080 -52.059  -50.739 1.00 70.33  ? 166  ASP   A CA  1 
ATOM   1232 C  C   . ASP   A 1 165 ? -24.467 -50.882  -51.648 1.00 73.61  ? 166  ASP   A C   1 
ATOM   1233 O  O   . ASP   A 1 165 ? -24.882 -51.133  -52.806 1.00 76.80  ? 166  ASP   A O   1 
ATOM   1234 C  CB  . ASP   A 1 165 ? -23.963 -53.374  -51.512 1.00 68.99  ? 166  ASP   A CB  1 
ATOM   1235 C  CG  . ASP   A 1 165 ? -22.912 -53.347  -52.604 1.00 69.86  ? 166  ASP   A CG  1 
ATOM   1236 O  OD1 . ASP   A 1 165 ? -22.045 -52.441  -52.567 1.00 67.92  ? 166  ASP   A OD1 1 
ATOM   1237 O  OD2 . ASP   A 1 165 ? -22.973 -54.231  -53.483 1.00 70.98  ? 166  ASP   A OD2 1 
ATOM   1238 N  N   . ILE   A 1 166 ? -24.340 -49.648  -51.146 1.00 70.02  ? 167  ILE   A N   1 
ATOM   1239 C  CA  . ILE   A 1 166 ? -24.894 -48.425  -51.803 1.00 68.80  ? 167  ILE   A CA  1 
ATOM   1240 C  C   . ILE   A 1 166 ? -23.827 -47.329  -51.911 1.00 71.32  ? 167  ILE   A C   1 
ATOM   1241 O  O   . ILE   A 1 166 ? -24.197 -46.190  -52.266 1.00 71.08  ? 167  ILE   A O   1 
ATOM   1242 C  CB  . ILE   A 1 166 ? -26.147 -47.942  -51.048 1.00 68.57  ? 167  ILE   A CB  1 
ATOM   1243 C  CG1 . ILE   A 1 166 ? -25.837 -47.591  -49.589 1.00 70.42  ? 167  ILE   A CG1 1 
ATOM   1244 C  CG2 . ILE   A 1 166 ? -27.257 -48.977  -51.158 1.00 70.16  ? 167  ILE   A CG2 1 
ATOM   1245 C  CD1 . ILE   A 1 166 ? -26.940 -46.837  -48.889 1.00 70.84  ? 167  ILE   A CD1 1 
ATOM   1246 N  N   . ILE   A 1 167 ? -22.558 -47.640  -51.631 1.00 70.90  ? 168  ILE   A N   1 
ATOM   1247 C  CA  . ILE   A 1 167 ? -21.417 -46.740  -51.965 1.00 72.85  ? 168  ILE   A CA  1 
ATOM   1248 C  C   . ILE   A 1 167 ? -20.832 -47.240  -53.289 1.00 77.80  ? 168  ILE   A C   1 
ATOM   1249 O  O   . ILE   A 1 167 ? -20.159 -48.286  -53.281 1.00 78.78  ? 168  ILE   A O   1 
ATOM   1250 C  CB  . ILE   A 1 167 ? -20.370 -46.664  -50.834 1.00 71.13  ? 168  ILE   A CB  1 
ATOM   1251 C  CG1 . ILE   A 1 167 ? -21.026 -46.501  -49.459 1.00 70.61  ? 168  ILE   A CG1 1 
ATOM   1252 C  CG2 . ILE   A 1 167 ? -19.372 -45.551  -51.125 1.00 69.22  ? 168  ILE   A CG2 1 
ATOM   1253 C  CD1 . ILE   A 1 167 ? -20.050 -46.372  -48.309 1.00 70.26  ? 168  ILE   A CD1 1 
ATOM   1254 N  N   . GLU   A 1 168 ? -21.127 -46.525  -54.380 1.00 82.91  ? 169  GLU   A N   1 
ATOM   1255 C  CA  . GLU   A 1 168 ? -20.772 -46.887  -55.781 1.00 84.28  ? 169  GLU   A CA  1 
ATOM   1256 C  C   . GLU   A 1 168 ? -19.262 -47.168  -55.890 1.00 81.28  ? 169  GLU   A C   1 
ATOM   1257 O  O   . GLU   A 1 168 ? -18.903 -48.125  -56.607 1.00 79.09  ? 169  GLU   A O   1 
ATOM   1258 C  CB  . GLU   A 1 168 ? -21.266 -45.781  -56.725 1.00 86.31  ? 169  GLU   A CB  1 
ATOM   1259 C  CG  . GLU   A 1 168 ? -20.534 -45.694  -58.055 1.00 88.30  ? 169  GLU   A CG  1 
ATOM   1260 C  CD  . GLU   A 1 168 ? -19.295 -44.812  -58.040 1.00 94.71  ? 169  GLU   A CD  1 
ATOM   1261 O  OE1 . GLU   A 1 168 ? -19.267 -43.832  -57.259 1.00 88.34  ? 169  GLU   A OE1 1 
ATOM   1262 O  OE2 . GLU   A 1 168 ? -18.352 -45.108  -58.806 1.00 103.39 ? 169  GLU   A OE2 1 
ATOM   1263 N  N   . ASN   A 1 169 ? -18.419 -46.394  -55.194 1.00 75.55  ? 170  ASN   A N   1 
ATOM   1264 C  CA  . ASN   A 1 169 ? -16.934 -46.452  -55.306 1.00 75.79  ? 170  ASN   A CA  1 
ATOM   1265 C  C   . ASN   A 1 169 ? -16.313 -47.166  -54.094 1.00 78.68  ? 170  ASN   A C   1 
ATOM   1266 O  O   . ASN   A 1 169 ? -15.099 -46.985  -53.865 1.00 80.08  ? 170  ASN   A O   1 
ATOM   1267 C  CB  . ASN   A 1 169 ? -16.336 -45.051  -55.459 1.00 75.94  ? 170  ASN   A CB  1 
ATOM   1268 C  CG  . ASN   A 1 169 ? -16.544 -44.176  -54.239 1.00 75.45  ? 170  ASN   A CG  1 
ATOM   1269 O  OD1 . ASN   A 1 169 ? -17.506 -44.355  -53.492 1.00 78.06  ? 170  ASN   A OD1 1 
ATOM   1270 N  ND2 . ASN   A 1 169 ? -15.655 -43.219  -54.034 1.00 72.71  ? 170  ASN   A ND2 1 
ATOM   1271 N  N   . ALA   A 1 170 ? -17.104 -47.943  -53.348 1.00 80.13  ? 171  ALA   A N   1 
ATOM   1272 C  CA  . ALA   A 1 170 ? -16.663 -48.735  -52.175 1.00 81.34  ? 171  ALA   A CA  1 
ATOM   1273 C  C   . ALA   A 1 170 ? -17.617 -49.914  -51.988 1.00 83.48  ? 171  ALA   A C   1 
ATOM   1274 O  O   . ALA   A 1 170 ? -18.435 -49.922  -51.070 1.00 81.98  ? 171  ALA   A O   1 
ATOM   1275 C  CB  . ALA   A 1 170 ? -16.598 -47.854  -50.948 1.00 78.28  ? 171  ALA   A CB  1 
ATOM   1276 N  N   . PRO   A 1 171 ? -17.556 -50.935  -52.872 1.00 85.82  ? 172  PRO   A N   1 
ATOM   1277 C  CA  . PRO   A 1 171 ? -18.516 -52.039  -52.842 1.00 87.74  ? 172  PRO   A CA  1 
ATOM   1278 C  C   . PRO   A 1 171 ? -18.277 -53.003  -51.669 1.00 88.48  ? 172  PRO   A C   1 
ATOM   1279 O  O   . PRO   A 1 171 ? -17.167 -53.053  -51.170 1.00 88.67  ? 172  PRO   A O   1 
ATOM   1280 C  CB  . PRO   A 1 171 ? -18.301 -52.740  -54.195 1.00 87.51  ? 172  PRO   A CB  1 
ATOM   1281 C  CG  . PRO   A 1 171 ? -16.864 -52.423  -54.568 1.00 86.66  ? 172  PRO   A CG  1 
ATOM   1282 C  CD  . PRO   A 1 171 ? -16.564 -51.072  -53.951 1.00 85.67  ? 172  PRO   A CD  1 
ATOM   1283 N  N   . THR   A 1 172 ? -19.323 -53.724  -51.254 1.00 89.04  ? 173  THR   A N   1 
ATOM   1284 C  CA  . THR   A 1 172 ? -19.258 -54.791  -50.219 1.00 92.29  ? 173  THR   A CA  1 
ATOM   1285 C  C   . THR   A 1 172 ? -18.633 -56.038  -50.854 1.00 103.45 ? 173  THR   A C   1 
ATOM   1286 O  O   . THR   A 1 172 ? -19.160 -56.496  -51.890 1.00 110.98 ? 173  THR   A O   1 
ATOM   1287 C  CB  . THR   A 1 172 ? -20.640 -55.075  -49.613 1.00 86.56  ? 173  THR   A CB  1 
ATOM   1288 O  OG1 . THR   A 1 172 ? -21.526 -55.509  -50.644 1.00 75.29  ? 173  THR   A OG1 1 
ATOM   1289 C  CG2 . THR   A 1 172 ? -21.231 -53.872  -48.910 1.00 84.30  ? 173  THR   A CG2 1 
ATOM   1290 N  N   . THR   A 1 173 ? -17.546 -56.548  -50.264 1.00 112.99 ? 174  THR   A N   1 
ATOM   1291 C  CA  . THR   A 1 173 ? -16.763 -57.708  -50.776 1.00 122.36 ? 174  THR   A CA  1 
ATOM   1292 C  C   . THR   A 1 173 ? -17.677 -58.942  -50.833 1.00 128.43 ? 174  THR   A C   1 
ATOM   1293 O  O   . THR   A 1 173 ? -18.284 -59.273  -49.795 1.00 129.66 ? 174  THR   A O   1 
ATOM   1294 C  CB  . THR   A 1 173 ? -15.483 -57.921  -49.951 1.00 120.83 ? 174  THR   A CB  1 
ATOM   1295 O  OG1 . THR   A 1 173 ? -14.710 -58.931  -50.600 1.00 123.36 ? 174  THR   A OG1 1 
ATOM   1296 C  CG2 . THR   A 1 173 ? -15.727 -58.321  -48.511 1.00 117.73 ? 174  THR   A CG2 1 
ATOM   1297 N  N   . HIS   A 1 174 ? -17.791 -59.567  -52.013 1.00 136.46 ? 175  HIS   A N   1 
ATOM   1298 C  CA  . HIS   A 1 174 ? -18.601 -60.793  -52.268 1.00 142.26 ? 175  HIS   A CA  1 
ATOM   1299 C  C   . HIS   A 1 174 ? -17.732 -62.043  -52.053 1.00 138.71 ? 175  HIS   A C   1 
ATOM   1300 O  O   . HIS   A 1 174 ? -18.299 -63.157  -52.033 1.00 136.13 ? 175  HIS   A O   1 
ATOM   1301 C  CB  . HIS   A 1 174 ? -19.235 -60.740  -53.671 1.00 149.29 ? 175  HIS   A CB  1 
ATOM   1302 C  CG  . HIS   A 1 174 ? -20.589 -61.368  -53.759 1.00 153.83 ? 175  HIS   A CG  1 
ATOM   1303 N  ND1 . HIS   A 1 174 ? -21.735 -60.624  -53.979 1.00 152.83 ? 175  HIS   A ND1 1 
ATOM   1304 C  CD2 . HIS   A 1 174 ? -20.990 -62.656  -53.662 1.00 153.74 ? 175  HIS   A CD2 1 
ATOM   1305 C  CE1 . HIS   A 1 174 ? -22.780 -61.427  -54.014 1.00 150.50 ? 175  HIS   A CE1 1 
ATOM   1306 N  NE2 . HIS   A 1 174 ? -22.350 -62.679  -53.821 1.00 150.88 ? 175  HIS   A NE2 1 
ATOM   1307 N  N   . THR   A 1 175 ? -16.411 -61.863  -51.907 1.00 132.23 ? 176  THR   A N   1 
ATOM   1308 C  CA  . THR   A 1 175 ? -15.435 -62.909  -51.493 1.00 125.97 ? 176  THR   A CA  1 
ATOM   1309 C  C   . THR   A 1 175 ? -15.861 -63.484  -50.138 1.00 127.44 ? 176  THR   A C   1 
ATOM   1310 O  O   . THR   A 1 175 ? -16.160 -62.677  -49.234 1.00 131.16 ? 176  THR   A O   1 
ATOM   1311 C  CB  . THR   A 1 175 ? -14.015 -62.334  -51.379 1.00 121.09 ? 176  THR   A CB  1 
ATOM   1312 O  OG1 . THR   A 1 175 ? -13.680 -61.701  -52.614 1.00 118.00 ? 176  THR   A OG1 1 
ATOM   1313 C  CG2 . THR   A 1 175 ? -12.967 -63.374  -51.047 1.00 116.24 ? 176  THR   A CG2 1 
ATOM   1314 N  N   . GLU   A 1 176 ? -15.890 -64.814  -49.996 1.00 126.95 ? 177  GLU   A N   1 
ATOM   1315 C  CA  . GLU   A 1 176 ? -16.076 -65.482  -48.679 1.00 125.17 ? 177  GLU   A CA  1 
ATOM   1316 C  C   . GLU   A 1 176 ? -14.791 -65.300  -47.865 1.00 122.80 ? 177  GLU   A C   1 
ATOM   1317 O  O   . GLU   A 1 176 ? -13.707 -65.606  -48.402 1.00 120.92 ? 177  GLU   A O   1 
ATOM   1318 C  CB  . GLU   A 1 176 ? -16.405 -66.970  -48.818 1.00 125.11 ? 177  GLU   A CB  1 
ATOM   1319 C  CG  . GLU   A 1 176 ? -16.373 -67.709  -47.486 1.00 125.99 ? 177  GLU   A CG  1 
ATOM   1320 C  CD  . GLU   A 1 176 ? -16.977 -69.103  -47.474 1.00 127.32 ? 177  GLU   A CD  1 
ATOM   1321 O  OE1 . GLU   A 1 176 ? -16.563 -69.912  -46.617 1.00 125.08 ? 177  GLU   A OE1 1 
ATOM   1322 O  OE2 . GLU   A 1 176 ? -17.863 -69.377  -48.308 1.00 129.72 ? 177  GLU   A OE2 1 
ATOM   1323 N  N   . GLU   A 1 177 ? -14.920 -64.820  -46.624 1.00 118.23 ? 178  GLU   A N   1 
ATOM   1324 C  CA  . GLU   A 1 177 ? -13.798 -64.642  -45.664 1.00 115.45 ? 178  GLU   A CA  1 
ATOM   1325 C  C   . GLU   A 1 177 ? -14.128 -65.407  -44.377 1.00 109.74 ? 178  GLU   A C   1 
ATOM   1326 O  O   . GLU   A 1 177 ? -14.774 -64.816  -43.485 1.00 107.26 ? 178  GLU   A O   1 
ATOM   1327 C  CB  . GLU   A 1 177 ? -13.559 -63.153  -45.411 1.00 119.40 ? 178  GLU   A CB  1 
ATOM   1328 C  CG  . GLU   A 1 177 ? -13.062 -62.409  -46.637 1.00 119.49 ? 178  GLU   A CG  1 
ATOM   1329 C  CD  . GLU   A 1 177 ? -12.865 -60.916  -46.439 1.00 122.71 ? 178  GLU   A CD  1 
ATOM   1330 O  OE1 . GLU   A 1 177 ? -12.990 -60.447  -45.287 1.00 121.37 ? 178  GLU   A OE1 1 
ATOM   1331 O  OE2 . GLU   A 1 177 ? -12.588 -60.225  -47.439 1.00 127.94 ? 178  GLU   A OE2 1 
ATOM   1332 N  N   . TYR   A 1 178 ? -13.709 -66.676  -44.302 1.00 101.72 ? 179  TYR   A N   1 
ATOM   1333 C  CA  . TYR   A 1 178 ? -13.978 -67.603  -43.170 1.00 94.59  ? 179  TYR   A CA  1 
ATOM   1334 C  C   . TYR   A 1 178 ? -13.550 -66.929  -41.861 1.00 87.30  ? 179  TYR   A C   1 
ATOM   1335 O  O   . TYR   A 1 178 ? -14.380 -66.846  -40.938 1.00 84.53  ? 179  TYR   A O   1 
ATOM   1336 C  CB  . TYR   A 1 178 ? -13.274 -68.949  -43.379 1.00 93.07  ? 179  TYR   A CB  1 
ATOM   1337 C  CG  . TYR   A 1 178 ? -13.820 -70.074  -42.534 1.00 94.38  ? 179  TYR   A CG  1 
ATOM   1338 C  CD1 . TYR   A 1 178 ? -14.882 -70.850  -42.975 1.00 96.68  ? 179  TYR   A CD1 1 
ATOM   1339 C  CD2 . TYR   A 1 178 ? -13.285 -70.362  -41.287 1.00 92.10  ? 179  TYR   A CD2 1 
ATOM   1340 C  CE1 . TYR   A 1 178 ? -15.394 -71.883  -42.203 1.00 95.97  ? 179  TYR   A CE1 1 
ATOM   1341 C  CE2 . TYR   A 1 178 ? -13.785 -71.389  -40.502 1.00 90.30  ? 179  TYR   A CE2 1 
ATOM   1342 C  CZ  . TYR   A 1 178 ? -14.844 -72.154  -40.961 1.00 92.42  ? 179  TYR   A CZ  1 
ATOM   1343 O  OH  . TYR   A 1 178 ? -15.347 -73.165  -40.194 1.00 89.27  ? 179  TYR   A OH  1 
ATOM   1344 N  N   . SER   A 1 179 ? -12.309 -66.436  -41.802 1.00 79.71  ? 180  SER   A N   1 
ATOM   1345 C  CA  . SER   A 1 179 ? -11.717 -65.755  -40.618 1.00 81.44  ? 180  SER   A CA  1 
ATOM   1346 C  C   . SER   A 1 179 ? -12.315 -64.350  -40.448 1.00 78.12  ? 180  SER   A C   1 
ATOM   1347 O  O   . SER   A 1 179 ? -12.662 -63.993  -39.302 1.00 71.52  ? 180  SER   A O   1 
ATOM   1348 C  CB  . SER   A 1 179 ? -10.212 -65.711  -40.706 1.00 81.10  ? 180  SER   A CB  1 
ATOM   1349 O  OG  . SER   A 1 179 ? -9.668  -67.015  -40.574 1.00 84.25  ? 180  SER   A OG  1 
ATOM   1350 N  N   . GLY   A 1 180 ? -12.429 -63.587  -41.541 1.00 75.02  ? 181  GLY   A N   1 
ATOM   1351 C  CA  . GLY   A 1 180 ? -12.998 -62.225  -41.553 1.00 75.58  ? 181  GLY   A CA  1 
ATOM   1352 C  C   . GLY   A 1 180 ? -14.407 -62.175  -40.977 1.00 77.57  ? 181  GLY   A C   1 
ATOM   1353 O  O   . GLY   A 1 180 ? -14.712 -61.206  -40.251 1.00 79.26  ? 181  GLY   A O   1 
ATOM   1354 N  N   . GLU   A 1 181 ? -15.241 -63.175  -41.280 1.00 74.82  ? 182  GLU   A N   1 
ATOM   1355 C  CA  . GLU   A 1 181 ? -16.665 -63.242  -40.849 1.00 75.10  ? 182  GLU   A CA  1 
ATOM   1356 C  C   . GLU   A 1 181 ? -16.756 -63.581  -39.351 1.00 72.03  ? 182  GLU   A C   1 
ATOM   1357 O  O   . GLU   A 1 181 ? -17.842 -63.381  -38.771 1.00 67.58  ? 182  GLU   A O   1 
ATOM   1358 C  CB  . GLU   A 1 181 ? -17.419 -64.254  -41.715 1.00 81.71  ? 182  GLU   A CB  1 
ATOM   1359 C  CG  . GLU   A 1 181 ? -17.654 -63.768  -43.138 1.00 86.74  ? 182  GLU   A CG  1 
ATOM   1360 C  CD  . GLU   A 1 181 ? -18.056 -64.841  -44.139 1.00 89.22  ? 182  GLU   A CD  1 
ATOM   1361 O  OE1 . GLU   A 1 181 ? -18.731 -65.810  -43.732 1.00 91.49  ? 182  GLU   A OE1 1 
ATOM   1362 O  OE2 . GLU   A 1 181 ? -17.693 -64.705  -45.328 1.00 89.65  ? 182  GLU   A OE2 1 
ATOM   1363 N  N   . GLU   A 1 182 ? -15.660 -64.065  -38.752 1.00 69.12  ? 183  GLU   A N   1 
ATOM   1364 C  CA  . GLU   A 1 182 ? -15.550 -64.421  -37.310 1.00 70.15  ? 183  GLU   A CA  1 
ATOM   1365 C  C   . GLU   A 1 182 ? -14.931 -63.271  -36.497 1.00 70.19  ? 183  GLU   A C   1 
ATOM   1366 O  O   . GLU   A 1 182 ? -14.757 -63.453  -35.275 1.00 75.05  ? 183  GLU   A O   1 
ATOM   1367 C  CB  . GLU   A 1 182 ? -14.670 -65.662  -37.140 1.00 72.53  ? 183  GLU   A CB  1 
ATOM   1368 C  CG  . GLU   A 1 182 ? -15.314 -66.959  -37.597 1.00 73.41  ? 183  GLU   A CG  1 
ATOM   1369 C  CD  . GLU   A 1 182 ? -14.384 -68.161  -37.547 1.00 72.97  ? 183  GLU   A CD  1 
ATOM   1370 O  OE1 . GLU   A 1 182 ? -13.186 -67.972  -37.246 1.00 68.59  ? 183  GLU   A OE1 1 
ATOM   1371 O  OE2 . GLU   A 1 182 ? -14.857 -69.284  -37.808 1.00 75.39  ? 183  GLU   A OE2 1 
ATOM   1372 N  N   . LYS   A 1 183 ? -14.618 -62.132  -37.126 1.00 64.90  ? 184  LYS   A N   1 
ATOM   1373 C  CA  . LYS   A 1 183 ? -13.741 -61.079  -36.543 1.00 63.62  ? 184  LYS   A CA  1 
ATOM   1374 C  C   . LYS   A 1 183 ? -14.272 -60.599  -35.184 1.00 61.11  ? 184  LYS   A C   1 
ATOM   1375 O  O   . LYS   A 1 183 ? -13.432 -60.281  -34.327 1.00 57.59  ? 184  LYS   A O   1 
ATOM   1376 C  CB  . LYS   A 1 183 ? -13.581 -59.900  -37.508 1.00 65.29  ? 184  LYS   A CB  1 
ATOM   1377 C  CG  . LYS   A 1 183 ? -14.826 -59.049  -37.728 1.00 66.53  ? 184  LYS   A CG  1 
ATOM   1378 C  CD  . LYS   A 1 183 ? -14.537 -57.723  -38.405 1.00 66.78  ? 184  LYS   A CD  1 
ATOM   1379 C  CE  . LYS   A 1 183 ? -13.875 -57.866  -39.758 1.00 68.29  ? 184  LYS   A CE  1 
ATOM   1380 N  NZ  . LYS   A 1 183 ? -14.691 -58.687  -40.684 1.00 69.49  ? 184  LYS   A NZ  1 
ATOM   1381 N  N   . THR   A 1 184 ? -15.596 -60.525  -34.995 1.00 60.07  ? 185  THR   A N   1 
ATOM   1382 C  CA  . THR   A 1 184 ? -16.229 -59.967  -33.765 1.00 57.95  ? 185  THR   A CA  1 
ATOM   1383 C  C   . THR   A 1 184 ? -15.989 -60.906  -32.582 1.00 58.29  ? 185  THR   A C   1 
ATOM   1384 O  O   . THR   A 1 184 ? -15.919 -60.406  -31.437 1.00 55.00  ? 185  THR   A O   1 
ATOM   1385 C  CB  . THR   A 1 184 ? -17.734 -59.722  -33.918 1.00 58.79  ? 185  THR   A CB  1 
ATOM   1386 O  OG1 . THR   A 1 184 ? -18.365 -60.974  -34.188 1.00 60.20  ? 185  THR   A OG1 1 
ATOM   1387 C  CG2 . THR   A 1 184 ? -18.056 -58.721  -35.004 1.00 60.94  ? 185  THR   A CG2 1 
ATOM   1388 N  N   . TRP   A 1 185 ? -15.884 -62.213  -32.830 1.00 56.96  ? 186  TRP   A N   1 
ATOM   1389 C  CA  . TRP   A 1 185 ? -15.435 -63.164  -31.784 1.00 56.73  ? 186  TRP   A CA  1 
ATOM   1390 C  C   . TRP   A 1 185 ? -14.039 -62.741  -31.310 1.00 54.79  ? 186  TRP   A C   1 
ATOM   1391 O  O   . TRP   A 1 185 ? -13.825 -62.684  -30.091 1.00 56.24  ? 186  TRP   A O   1 
ATOM   1392 C  CB  . TRP   A 1 185 ? -15.464 -64.622  -32.253 1.00 55.85  ? 186  TRP   A CB  1 
ATOM   1393 C  CG  . TRP   A 1 185 ? -15.011 -65.536  -31.159 1.00 57.79  ? 186  TRP   A CG  1 
ATOM   1394 C  CD1 . TRP   A 1 185 ? -15.778 -66.100  -30.181 1.00 59.78  ? 186  TRP   A CD1 1 
ATOM   1395 C  CD2 . TRP   A 1 185 ? -13.655 -65.919  -30.876 1.00 58.01  ? 186  TRP   A CD2 1 
ATOM   1396 N  NE1 . TRP   A 1 185 ? -14.999 -66.836  -29.330 1.00 59.72  ? 186  TRP   A NE1 1 
ATOM   1397 C  CE2 . TRP   A 1 185 ? -13.690 -66.739  -29.729 1.00 59.87  ? 186  TRP   A CE2 1 
ATOM   1398 C  CE3 . TRP   A 1 185 ? -12.422 -65.661  -31.487 1.00 56.52  ? 186  TRP   A CE3 1 
ATOM   1399 C  CZ2 . TRP   A 1 185 ? -12.534 -67.300  -29.186 1.00 60.42  ? 186  TRP   A CZ2 1 
ATOM   1400 C  CZ3 . TRP   A 1 185 ? -11.281 -66.205  -30.944 1.00 55.60  ? 186  TRP   A CZ3 1 
ATOM   1401 C  CH2 . TRP   A 1 185 ? -11.340 -67.017  -29.812 1.00 58.17  ? 186  TRP   A CH2 1 
ATOM   1402 N  N   . MET   A 1 186 ? -13.134 -62.435  -32.238 1.00 54.61  ? 187  MET   A N   1 
ATOM   1403 C  CA  . MET   A 1 186 ? -11.733 -62.073  -31.907 1.00 59.10  ? 187  MET   A CA  1 
ATOM   1404 C  C   . MET   A 1 186 ? -11.727 -60.758  -31.112 1.00 58.46  ? 187  MET   A C   1 
ATOM   1405 O  O   . MET   A 1 186 ? -10.909 -60.654  -30.164 1.00 55.83  ? 187  MET   A O   1 
ATOM   1406 C  CB  . MET   A 1 186 ? -10.875 -61.950  -33.170 1.00 64.62  ? 187  MET   A CB  1 
ATOM   1407 C  CG  . MET   A 1 186 ? -9.379  -61.846  -32.890 1.00 73.61  ? 187  MET   A CG  1 
ATOM   1408 S  SD  . MET   A 1 186 ? -8.647  -63.358  -32.182 1.00 89.28  ? 187  MET   A SD  1 
ATOM   1409 C  CE  . MET   A 1 186 ? -8.602  -64.425  -33.622 1.00 85.89  ? 187  MET   A CE  1 
ATOM   1410 N  N   . TRP   A 1 187 ? -12.617 -59.812  -31.448 1.00 54.82  ? 188  TRP   A N   1 
ATOM   1411 C  CA  . TRP   A 1 187 ? -12.823 -58.555  -30.674 1.00 55.04  ? 188  TRP   A CA  1 
ATOM   1412 C  C   . TRP   A 1 187 ? -13.031 -58.913  -29.201 1.00 54.64  ? 188  TRP   A C   1 
ATOM   1413 O  O   . TRP   A 1 187 ? -12.370 -58.309  -28.333 1.00 54.82  ? 188  TRP   A O   1 
ATOM   1414 C  CB  . TRP   A 1 187 ? -14.028 -57.748  -31.176 1.00 57.27  ? 188  TRP   A CB  1 
ATOM   1415 C  CG  . TRP   A 1 187 ? -13.939 -57.202  -32.568 1.00 59.66  ? 188  TRP   A CG  1 
ATOM   1416 C  CD1 . TRP   A 1 187 ? -12.910 -57.324  -33.456 1.00 61.53  ? 188  TRP   A CD1 1 
ATOM   1417 C  CD2 . TRP   A 1 187 ? -14.937 -56.398  -33.219 1.00 59.95  ? 188  TRP   A CD2 1 
ATOM   1418 N  NE1 . TRP   A 1 187 ? -13.209 -56.669  -34.620 1.00 62.43  ? 188  TRP   A NE1 1 
ATOM   1419 C  CE2 . TRP   A 1 187 ? -14.444 -56.088  -34.504 1.00 62.33  ? 188  TRP   A CE2 1 
ATOM   1420 C  CE3 . TRP   A 1 187 ? -16.199 -55.922  -32.846 1.00 61.53  ? 188  TRP   A CE3 1 
ATOM   1421 C  CZ2 . TRP   A 1 187 ? -15.173 -55.321  -35.413 1.00 64.23  ? 188  TRP   A CZ2 1 
ATOM   1422 C  CZ3 . TRP   A 1 187 ? -16.918 -55.164  -33.744 1.00 63.16  ? 188  TRP   A CZ3 1 
ATOM   1423 C  CH2 . TRP   A 1 187 ? -16.410 -54.869  -35.010 1.00 64.17  ? 188  TRP   A CH2 1 
ATOM   1424 N  N   . TRP   A 1 188 ? -13.947 -59.854  -28.954 1.00 52.66  ? 189  TRP   A N   1 
ATOM   1425 C  CA  . TRP   A 1 188 ? -14.334 -60.351  -27.610 1.00 52.03  ? 189  TRP   A CA  1 
ATOM   1426 C  C   . TRP   A 1 188 ? -13.154 -61.084  -26.967 1.00 52.76  ? 189  TRP   A C   1 
ATOM   1427 O  O   . TRP   A 1 188 ? -12.820 -60.765  -25.808 1.00 52.07  ? 189  TRP   A O   1 
ATOM   1428 C  CB  . TRP   A 1 188 ? -15.565 -61.257  -27.709 1.00 52.26  ? 189  TRP   A CB  1 
ATOM   1429 C  CG  . TRP   A 1 188 ? -15.652 -62.234  -26.582 1.00 53.04  ? 189  TRP   A CG  1 
ATOM   1430 C  CD1 . TRP   A 1 188 ? -15.448 -63.581  -26.645 1.00 53.22  ? 189  TRP   A CD1 1 
ATOM   1431 C  CD2 . TRP   A 1 188 ? -15.925 -61.930  -25.202 1.00 54.12  ? 189  TRP   A CD2 1 
ATOM   1432 N  NE1 . TRP   A 1 188 ? -15.593 -64.137  -25.403 1.00 55.27  ? 189  TRP   A NE1 1 
ATOM   1433 C  CE2 . TRP   A 1 188 ? -15.886 -63.152  -24.497 1.00 54.84  ? 189  TRP   A CE2 1 
ATOM   1434 C  CE3 . TRP   A 1 188 ? -16.207 -60.755  -24.498 1.00 54.79  ? 189  TRP   A CE3 1 
ATOM   1435 C  CZ2 . TRP   A 1 188 ? -16.114 -63.226  -23.122 1.00 54.86  ? 189  TRP   A CZ2 1 
ATOM   1436 C  CZ3 . TRP   A 1 188 ? -16.434 -60.828  -23.140 1.00 54.87  ? 189  TRP   A CZ3 1 
ATOM   1437 C  CH2 . TRP   A 1 188 ? -16.388 -62.048  -22.464 1.00 55.33  ? 189  TRP   A CH2 1 
ATOM   1438 N  N   . HIS   A 1 189 ? -12.565 -62.041  -27.690 1.00 53.72  ? 190  HIS   A N   1 
ATOM   1439 C  CA  . HIS   A 1 189 ? -11.452 -62.900  -27.204 1.00 54.86  ? 190  HIS   A CA  1 
ATOM   1440 C  C   . HIS   A 1 189 ? -10.298 -62.021  -26.714 1.00 54.95  ? 190  HIS   A C   1 
ATOM   1441 O  O   . HIS   A 1 189 ? -9.807  -62.262  -25.591 1.00 54.22  ? 190  HIS   A O   1 
ATOM   1442 C  CB  . HIS   A 1 189 ? -10.978 -63.872  -28.289 1.00 55.92  ? 190  HIS   A CB  1 
ATOM   1443 C  CG  . HIS   A 1 189 ? -9.867  -64.755  -27.829 1.00 56.10  ? 190  HIS   A CG  1 
ATOM   1444 N  ND1 . HIS   A 1 189 ? -10.023 -65.642  -26.787 1.00 55.08  ? 190  HIS   A ND1 1 
ATOM   1445 C  CD2 . HIS   A 1 189 ? -8.590  -64.880  -28.246 1.00 56.49  ? 190  HIS   A CD2 1 
ATOM   1446 C  CE1 . HIS   A 1 189 ? -8.893  -66.286  -26.589 1.00 57.39  ? 190  HIS   A CE1 1 
ATOM   1447 N  NE2 . HIS   A 1 189 ? -7.999  -65.842  -27.474 1.00 57.61  ? 190  HIS   A NE2 1 
ATOM   1448 N  N   . ASN   A 1 190 ? -9.890  -61.046  -27.529 1.00 52.18  ? 191  ASN   A N   1 
ATOM   1449 C  CA  . ASN   A 1 190 ? -8.778  -60.118  -27.202 1.00 50.79  ? 191  ASN   A CA  1 
ATOM   1450 C  C   . ASN   A 1 190 ? -9.148  -59.332  -25.942 1.00 51.68  ? 191  ASN   A C   1 
ATOM   1451 O  O   . ASN   A 1 190 ? -8.307  -59.264  -25.032 1.00 53.89  ? 191  ASN   A O   1 
ATOM   1452 C  CB  . ASN   A 1 190 ? -8.428  -59.214  -28.383 1.00 52.51  ? 191  ASN   A CB  1 
ATOM   1453 C  CG  . ASN   A 1 190 ? -7.680  -59.948  -29.478 1.00 54.21  ? 191  ASN   A CG  1 
ATOM   1454 O  OD1 . ASN   A 1 190 ? -7.112  -61.012  -29.247 1.00 59.19  ? 191  ASN   A OD1 1 
ATOM   1455 N  ND2 . ASN   A 1 190 ? -7.668  -59.388  -30.674 1.00 56.17  ? 191  ASN   A ND2 1 
ATOM   1456 N  N   . PHE   A 1 191 ? -10.372 -58.808  -25.862 1.00 50.06  ? 192  PHE   A N   1 
ATOM   1457 C  CA  . PHE   A 1 191 ? -10.820 -57.954  -24.731 1.00 48.67  ? 192  PHE   A CA  1 
ATOM   1458 C  C   . PHE   A 1 191 ? -10.800 -58.763  -23.426 1.00 49.61  ? 192  PHE   A C   1 
ATOM   1459 O  O   . PHE   A 1 191 ? -10.236 -58.264  -22.432 1.00 50.67  ? 192  PHE   A O   1 
ATOM   1460 C  CB  . PHE   A 1 191 ? -12.198 -57.349  -25.005 1.00 46.89  ? 192  PHE   A CB  1 
ATOM   1461 C  CG  . PHE   A 1 191 ? -12.706 -56.453  -23.906 1.00 45.16  ? 192  PHE   A CG  1 
ATOM   1462 C  CD1 . PHE   A 1 191 ? -12.243 -55.153  -23.784 1.00 45.90  ? 192  PHE   A CD1 1 
ATOM   1463 C  CD2 . PHE   A 1 191 ? -13.648 -56.905  -22.996 1.00 45.17  ? 192  PHE   A CD2 1 
ATOM   1464 C  CE1 . PHE   A 1 191 ? -12.707 -54.324  -22.774 1.00 46.89  ? 192  PHE   A CE1 1 
ATOM   1465 C  CE2 . PHE   A 1 191 ? -14.111 -56.076  -21.985 1.00 46.16  ? 192  PHE   A CE2 1 
ATOM   1466 C  CZ  . PHE   A 1 191 ? -13.641 -54.788  -21.876 1.00 47.77  ? 192  PHE   A CZ  1 
ATOM   1467 N  N   . ARG   A 1 192 ? -11.386 -59.965  -23.421 1.00 48.59  ? 193  ARG   A N   1 
ATOM   1468 C  CA  . ARG   A 1 192 ? -11.504 -60.798  -22.193 1.00 49.45  ? 193  ARG   A CA  1 
ATOM   1469 C  C   . ARG   A 1 192 ? -10.130 -61.378  -21.822 1.00 50.28  ? 193  ARG   A C   1 
ATOM   1470 O  O   . ARG   A 1 192 ? -9.901  -61.584  -20.618 1.00 53.09  ? 193  ARG   A O   1 
ATOM   1471 C  CB  . ARG   A 1 192 ? -12.577 -61.882  -22.342 1.00 50.61  ? 193  ARG   A CB  1 
ATOM   1472 C  CG  . ARG   A 1 192 ? -12.315 -62.908  -23.432 1.00 53.48  ? 193  ARG   A CG  1 
ATOM   1473 C  CD  . ARG   A 1 192 ? -11.489 -64.123  -23.035 1.00 55.12  ? 193  ARG   A CD  1 
ATOM   1474 N  NE  . ARG   A 1 192 ? -11.557 -65.088  -24.128 1.00 55.24  ? 193  ARG   A NE  1 
ATOM   1475 C  CZ  . ARG   A 1 192 ? -12.585 -65.903  -24.359 1.00 53.07  ? 193  ARG   A CZ  1 
ATOM   1476 N  NH1 . ARG   A 1 192 ? -13.625 -65.911  -23.541 1.00 51.19  ? 193  ARG   A NH1 1 
ATOM   1477 N  NH2 . ARG   A 1 192 ? -12.566 -66.715  -25.403 1.00 50.91  ? 193  ARG   A NH2 1 
ATOM   1478 N  N   . THR   A 1 193 ? -9.244  -61.612  -22.798 1.00 49.79  ? 194  THR   A N   1 
ATOM   1479 C  CA  . THR   A 1 193 ? -7.838  -62.040  -22.555 1.00 47.78  ? 194  THR   A CA  1 
ATOM   1480 C  C   . THR   A 1 193 ? -7.088  -60.919  -21.826 1.00 48.91  ? 194  THR   A C   1 
ATOM   1481 O  O   . THR   A 1 193 ? -6.429  -61.221  -20.818 1.00 50.59  ? 194  THR   A O   1 
ATOM   1482 C  CB  . THR   A 1 193 ? -7.119  -62.433  -23.849 1.00 46.09  ? 194  THR   A CB  1 
ATOM   1483 O  OG1 . THR   A 1 193 ? -7.778  -63.574  -24.397 1.00 44.87  ? 194  THR   A OG1 1 
ATOM   1484 C  CG2 . THR   A 1 193 ? -5.659  -62.763  -23.635 1.00 46.64  ? 194  THR   A CG2 1 
ATOM   1485 N  N   . LEU   A 1 194 ? -7.193  -59.680  -22.314 1.00 48.51  ? 195  LEU   A N   1 
ATOM   1486 C  CA  . LEU   A 1 194 ? -6.535  -58.487  -21.713 1.00 49.73  ? 195  LEU   A CA  1 
ATOM   1487 C  C   . LEU   A 1 194 ? -7.019  -58.310  -20.264 1.00 51.49  ? 195  LEU   A C   1 
ATOM   1488 O  O   . LEU   A 1 194 ? -6.191  -57.935  -19.412 1.00 49.14  ? 195  LEU   A O   1 
ATOM   1489 C  CB  . LEU   A 1 194 ? -6.856  -57.242  -22.550 1.00 50.52  ? 195  LEU   A CB  1 
ATOM   1490 C  CG  . LEU   A 1 194 ? -6.140  -57.111  -23.896 1.00 49.95  ? 195  LEU   A CG  1 
ATOM   1491 C  CD1 . LEU   A 1 194 ? -6.880  -56.143  -24.804 1.00 51.63  ? 195  LEU   A CD1 1 
ATOM   1492 C  CD2 . LEU   A 1 194 ? -4.704  -56.654  -23.721 1.00 50.79  ? 195  LEU   A CD2 1 
ATOM   1493 N  N   . CYS   A 1 195 ? -8.306  -58.570  -19.998 1.00 51.87  ? 196  CYS   A N   1 
ATOM   1494 C  CA  . CYS   A 1 195 ? -8.950  -58.419  -18.661 1.00 54.46  ? 196  CYS   A CA  1 
ATOM   1495 C  C   . CYS   A 1 195 ? -8.736  -59.682  -17.810 1.00 55.40  ? 196  CYS   A C   1 
ATOM   1496 O  O   . CYS   A 1 195 ? -9.335  -59.755  -16.720 1.00 54.41  ? 196  CYS   A O   1 
ATOM   1497 C  CB  . CYS   A 1 195 ? -10.445 -58.144  -18.786 1.00 56.56  ? 196  CYS   A CB  1 
ATOM   1498 S  SG  . CYS   A 1 195 ? -10.846 -56.592  -19.629 1.00 58.09  ? 196  CYS   A SG  1 
ATOM   1499 N  N   . ASP   A 1 196 ? -7.927  -60.628  -18.304 1.00 54.57  ? 197  ASP   A N   1 
ATOM   1500 C  CA  . ASP   A 1 196 ? -7.527  -61.895  -17.633 1.00 55.58  ? 197  ASP   A CA  1 
ATOM   1501 C  C   . ASP   A 1 196 ? -8.773  -62.651  -17.162 1.00 53.90  ? 197  ASP   A C   1 
ATOM   1502 O  O   . ASP   A 1 196 ? -8.831  -63.015  -15.976 1.00 54.52  ? 197  ASP   A O   1 
ATOM   1503 C  CB  . ASP   A 1 196 ? -6.531  -61.660  -16.491 1.00 56.37  ? 197  ASP   A CB  1 
ATOM   1504 C  CG  . ASP   A 1 196 ? -5.618  -62.854  -16.238 1.00 59.63  ? 197  ASP   A CG  1 
ATOM   1505 O  OD1 . ASP   A 1 196 ? -5.764  -63.875  -16.955 1.00 60.58  ? 197  ASP   A OD1 1 
ATOM   1506 O  OD2 . ASP   A 1 196 ? -4.760  -62.758  -15.335 1.00 62.60  ? 197  ASP   A OD2 1 
ATOM   1507 N  N   . TYR   A 1 197 ? -9.720  -62.878  -18.074 1.00 54.40  ? 198  TYR   A N   1 
ATOM   1508 C  CA  . TYR   A 1 197 ? -10.866 -63.813  -17.920 1.00 54.00  ? 198  TYR   A CA  1 
ATOM   1509 C  C   . TYR   A 1 197 ? -11.688 -63.486  -16.666 1.00 54.86  ? 198  TYR   A C   1 
ATOM   1510 O  O   . TYR   A 1 197 ? -12.234 -64.426  -16.068 1.00 60.54  ? 198  TYR   A O   1 
ATOM   1511 C  CB  . TYR   A 1 197 ? -10.354 -65.255  -17.865 1.00 52.95  ? 198  TYR   A CB  1 
ATOM   1512 C  CG  . TYR   A 1 197 ? -9.924  -65.812  -19.197 1.00 52.52  ? 198  TYR   A CG  1 
ATOM   1513 C  CD1 . TYR   A 1 197 ? -8.714  -65.447  -19.765 1.00 51.46  ? 198  TYR   A CD1 1 
ATOM   1514 C  CD2 . TYR   A 1 197 ? -10.730 -66.699  -19.891 1.00 51.14  ? 198  TYR   A CD2 1 
ATOM   1515 C  CE1 . TYR   A 1 197 ? -8.316  -65.948  -20.991 1.00 51.05  ? 198  TYR   A CE1 1 
ATOM   1516 C  CE2 . TYR   A 1 197 ? -10.346 -67.208  -21.120 1.00 51.47  ? 198  TYR   A CE2 1 
ATOM   1517 C  CZ  . TYR   A 1 197 ? -9.136  -66.830  -21.672 1.00 51.40  ? 198  TYR   A CZ  1 
ATOM   1518 O  OH  . TYR   A 1 197 ? -8.752  -67.325  -22.882 1.00 54.74  ? 198  TYR   A OH  1 
ATOM   1519 N  N   . SER   A 1 198 ? -11.800 -62.212  -16.275 1.00 52.13  ? 199  SER   A N   1 
ATOM   1520 C  CA  . SER   A 1 198 ? -12.649 -61.797  -15.130 1.00 51.51  ? 199  SER   A CA  1 
ATOM   1521 C  C   . SER   A 1 198 ? -14.008 -62.492  -15.258 1.00 53.73  ? 199  SER   A C   1 
ATOM   1522 O  O   . SER   A 1 198 ? -14.608 -62.419  -16.351 1.00 55.44  ? 199  SER   A O   1 
ATOM   1523 C  CB  . SER   A 1 198 ? -12.806 -60.304  -15.057 1.00 51.83  ? 199  SER   A CB  1 
ATOM   1524 O  OG  . SER   A 1 198 ? -13.836 -59.945  -14.146 1.00 50.66  ? 199  SER   A OG  1 
ATOM   1525 N  N   . LYS   A 1 199 ? -14.464 -63.156  -14.195 1.00 54.96  ? 200  LYS   A N   1 
ATOM   1526 C  CA  . LYS   A 1 199 ? -15.786 -63.838  -14.155 1.00 58.33  ? 200  LYS   A CA  1 
ATOM   1527 C  C   . LYS   A 1 199 ? -16.911 -62.792  -14.200 1.00 56.46  ? 200  LYS   A C   1 
ATOM   1528 O  O   . LYS   A 1 199 ? -18.074 -63.199  -14.384 1.00 55.59  ? 200  LYS   A O   1 
ATOM   1529 C  CB  . LYS   A 1 199 ? -15.908 -64.724  -12.911 1.00 62.65  ? 200  LYS   A CB  1 
ATOM   1530 C  CG  . LYS   A 1 199 ? -15.637 -64.026  -11.585 1.00 69.70  ? 200  LYS   A CG  1 
ATOM   1531 C  CD  . LYS   A 1 199 ? -16.164 -64.770  -10.374 1.00 76.82  ? 200  LYS   A CD  1 
ATOM   1532 C  CE  . LYS   A 1 199 ? -16.011 -63.972  -9.095  1.00 82.63  ? 200  LYS   A CE  1 
ATOM   1533 N  NZ  . LYS   A 1 199 ? -16.509 -64.720  -7.917  1.00 85.98  ? 200  LYS   A NZ  1 
ATOM   1534 N  N   . ARG   A 1 200 ? -16.580 -61.505  -14.039 1.00 52.99  ? 201  ARG   A N   1 
ATOM   1535 C  CA  . ARG   A 1 200 ? -17.557 -60.384  -14.015 1.00 54.17  ? 201  ARG   A CA  1 
ATOM   1536 C  C   . ARG   A 1 200 ? -17.802 -59.846  -15.433 1.00 54.01  ? 201  ARG   A C   1 
ATOM   1537 O  O   . ARG   A 1 200 ? -18.708 -59.000  -15.589 1.00 53.50  ? 201  ARG   A O   1 
ATOM   1538 C  CB  . ARG   A 1 200 ? -17.059 -59.269  -13.092 1.00 55.23  ? 201  ARG   A CB  1 
ATOM   1539 C  CG  . ARG   A 1 200 ? -17.022 -59.661  -11.624 1.00 57.89  ? 201  ARG   A CG  1 
ATOM   1540 C  CD  . ARG   A 1 200 ? -16.483 -58.542  -10.758 1.00 62.50  ? 201  ARG   A CD  1 
ATOM   1541 N  NE  . ARG   A 1 200 ? -17.358 -57.376  -10.765 1.00 65.50  ? 201  ARG   A NE  1 
ATOM   1542 C  CZ  . ARG   A 1 200 ? -17.049 -56.183  -10.257 1.00 68.07  ? 201  ARG   A CZ  1 
ATOM   1543 N  NH1 . ARG   A 1 200 ? -17.927 -55.197  -10.320 1.00 71.29  ? 201  ARG   A NH1 1 
ATOM   1544 N  NH2 . ARG   A 1 200 ? -15.876 -55.975  -9.685  1.00 69.22  ? 201  ARG   A NH2 1 
ATOM   1545 N  N   . ILE   A 1 201 ? -17.031 -60.308  -16.423 1.00 52.37  ? 202  ILE   A N   1 
ATOM   1546 C  CA  . ILE   A 1 201 ? -17.111 -59.840  -17.837 1.00 51.55  ? 202  ILE   A CA  1 
ATOM   1547 C  C   . ILE   A 1 201 ? -17.739 -60.954  -18.679 1.00 50.58  ? 202  ILE   A C   1 
ATOM   1548 O  O   . ILE   A 1 201 ? -17.098 -62.004  -18.846 1.00 50.05  ? 202  ILE   A O   1 
ATOM   1549 C  CB  . ILE   A 1 201 ? -15.721 -59.421  -18.353 1.00 50.52  ? 202  ILE   A CB  1 
ATOM   1550 C  CG1 . ILE   A 1 201 ? -15.116 -58.319  -17.481 1.00 52.19  ? 202  ILE   A CG1 1 
ATOM   1551 C  CG2 . ILE   A 1 201 ? -15.790 -59.009  -19.814 1.00 50.35  ? 202  ILE   A CG2 1 
ATOM   1552 C  CD1 . ILE   A 1 201 ? -13.690 -57.964  -17.835 1.00 53.56  ? 202  ILE   A CD1 1 
ATOM   1553 N  N   . ALA   A 1 202 ? -18.957 -60.723  -19.174 1.00 49.82  ? 203  ALA   A N   1 
ATOM   1554 C  CA  . ALA   A 1 202 ? -19.740 -61.678  -19.989 1.00 51.29  ? 203  ALA   A CA  1 
ATOM   1555 C  C   . ALA   A 1 202 ? -20.175 -60.986  -21.285 1.00 52.25  ? 203  ALA   A C   1 
ATOM   1556 O  O   . ALA   A 1 202 ? -19.906 -59.776  -21.428 1.00 51.14  ? 203  ALA   A O   1 
ATOM   1557 C  CB  . ALA   A 1 202 ? -20.915 -62.181  -19.187 1.00 51.39  ? 203  ALA   A CB  1 
ATOM   1558 N  N   . VAL   A 1 203 ? -20.821 -61.732  -22.184 1.00 54.93  ? 204  VAL   A N   1 
ATOM   1559 C  CA  . VAL   A 1 203 ? -21.227 -61.266  -23.545 1.00 57.20  ? 204  VAL   A CA  1 
ATOM   1560 C  C   . VAL   A 1 203 ? -22.721 -60.920  -23.549 1.00 58.79  ? 204  VAL   A C   1 
ATOM   1561 O  O   . VAL   A 1 203 ? -23.526 -61.720  -23.018 1.00 59.58  ? 204  VAL   A O   1 
ATOM   1562 C  CB  . VAL   A 1 203 ? -20.899 -62.329  -24.611 1.00 56.20  ? 204  VAL   A CB  1 
ATOM   1563 C  CG1 . VAL   A 1 203 ? -21.310 -61.879  -26.003 1.00 55.83  ? 204  VAL   A CG1 1 
ATOM   1564 C  CG2 . VAL   A 1 203 ? -19.425 -62.709  -24.587 1.00 58.40  ? 204  VAL   A CG2 1 
ATOM   1565 N  N   . ALA   A 1 204 ? -23.061 -59.756  -24.113 1.00 60.44  ? 205  ALA   A N   1 
ATOM   1566 C  CA  . ALA   A 1 204 ? -24.408 -59.408  -24.628 1.00 60.24  ? 205  ALA   A CA  1 
ATOM   1567 C  C   . ALA   A 1 204 ? -24.339 -59.467  -26.155 1.00 57.62  ? 205  ALA   A C   1 
ATOM   1568 O  O   . ALA   A 1 204 ? -23.856 -58.494  -26.761 1.00 57.42  ? 205  ALA   A O   1 
ATOM   1569 C  CB  . ALA   A 1 204 ? -24.848 -58.048  -24.136 1.00 58.76  ? 205  ALA   A CB  1 
ATOM   1570 N  N   . LEU   A 1 205 ? -24.750 -60.594  -26.739 1.00 56.42  ? 206  LEU   A N   1 
ATOM   1571 C  CA  . LEU   A 1 205 ? -24.546 -60.904  -28.177 1.00 57.76  ? 206  LEU   A CA  1 
ATOM   1572 C  C   . LEU   A 1 205 ? -25.686 -60.278  -28.982 1.00 58.77  ? 206  LEU   A C   1 
ATOM   1573 O  O   . LEU   A 1 205 ? -26.825 -60.740  -28.838 1.00 58.01  ? 206  LEU   A O   1 
ATOM   1574 C  CB  . LEU   A 1 205 ? -24.487 -62.423  -28.358 1.00 57.39  ? 206  LEU   A CB  1 
ATOM   1575 C  CG  . LEU   A 1 205 ? -24.027 -62.902  -29.733 1.00 60.78  ? 206  LEU   A CG  1 
ATOM   1576 C  CD1 . LEU   A 1 205 ? -22.558 -62.581  -29.959 1.00 63.93  ? 206  LEU   A CD1 1 
ATOM   1577 C  CD2 . LEU   A 1 205 ? -24.269 -64.395  -29.898 1.00 61.18  ? 206  LEU   A CD2 1 
ATOM   1578 N  N   . GLU   A 1 206 ? -25.380 -59.251  -29.779 1.00 63.38  ? 207  GLU   A N   1 
ATOM   1579 C  CA  . GLU   A 1 206 ? -26.368 -58.506  -30.604 1.00 66.13  ? 207  GLU   A CA  1 
ATOM   1580 C  C   . GLU   A 1 206 ? -26.610 -59.283  -31.905 1.00 67.83  ? 207  GLU   A C   1 
ATOM   1581 O  O   . GLU   A 1 206 ? -25.641 -59.492  -32.665 1.00 70.53  ? 207  GLU   A O   1 
ATOM   1582 C  CB  . GLU   A 1 206 ? -25.877 -57.076  -30.841 1.00 68.67  ? 207  GLU   A CB  1 
ATOM   1583 C  CG  . GLU   A 1 206 ? -26.978 -56.108  -31.244 1.00 73.08  ? 207  GLU   A CG  1 
ATOM   1584 C  CD  . GLU   A 1 206 ? -26.748 -54.657  -30.852 1.00 74.89  ? 207  GLU   A CD  1 
ATOM   1585 O  OE1 . GLU   A 1 206 ? -25.578 -54.229  -30.792 1.00 77.08  ? 207  GLU   A OE1 1 
ATOM   1586 O  OE2 . GLU   A 1 206 ? -27.745 -53.959  -30.596 1.00 80.73  ? 207  GLU   A OE2 1 
ATOM   1587 N  N   . ILE   A 1 207 ? -27.859 -59.702  -32.135 1.00 69.48  ? 208  ILE   A N   1 
ATOM   1588 C  CA  . ILE   A 1 207 ? -28.307 -60.491  -33.323 1.00 71.49  ? 208  ILE   A CA  1 
ATOM   1589 C  C   . ILE   A 1 207 ? -28.767 -59.520  -34.421 1.00 72.32  ? 208  ILE   A C   1 
ATOM   1590 O  O   . ILE   A 1 207 ? -29.584 -58.631  -34.117 1.00 70.58  ? 208  ILE   A O   1 
ATOM   1591 C  CB  . ILE   A 1 207 ? -29.429 -61.475  -32.925 1.00 73.57  ? 208  ILE   A CB  1 
ATOM   1592 C  CG1 . ILE   A 1 207 ? -29.105 -62.251  -31.642 1.00 75.34  ? 208  ILE   A CG1 1 
ATOM   1593 C  CG2 . ILE   A 1 207 ? -29.767 -62.412  -34.074 1.00 73.52  ? 208  ILE   A CG2 1 
ATOM   1594 C  CD1 . ILE   A 1 207 ? -27.762 -62.943  -31.648 1.00 77.42  ? 208  ILE   A CD1 1 
ATOM   1595 N  N   . GLY   A 1 208 ? -28.258 -59.688  -35.648 1.00 74.44  ? 209  GLY   A N   1 
ATOM   1596 C  CA  . GLY   A 1 208 ? -28.597 -58.858  -36.823 1.00 75.78  ? 209  GLY   A CA  1 
ATOM   1597 C  C   . GLY   A 1 208 ? -29.688 -59.484  -37.685 1.00 79.45  ? 209  GLY   A C   1 
ATOM   1598 O  O   . GLY   A 1 208 ? -30.099 -60.638  -37.400 1.00 72.76  ? 209  GLY   A O   1 
ATOM   1599 N  N   . ALA   A 1 209 ? -30.140 -58.751  -38.711 1.00 83.29  ? 210  ALA   A N   1 
ATOM   1600 C  CA  . ALA   A 1 209 ? -31.208 -59.155  -39.658 1.00 83.70  ? 210  ALA   A CA  1 
ATOM   1601 C  C   . ALA   A 1 209 ? -30.771 -60.404  -40.434 1.00 82.02  ? 210  ALA   A C   1 
ATOM   1602 O  O   . ALA   A 1 209 ? -31.522 -61.394  -40.441 1.00 80.54  ? 210  ALA   A O   1 
ATOM   1603 C  CB  . ALA   A 1 209 ? -31.535 -58.012  -40.589 1.00 84.09  ? 210  ALA   A CB  1 
ATOM   1604 N  N   . ASP   A 1 210 ? -29.597 -60.353  -41.065 1.00 84.76  ? 211  ASP   A N   1 
ATOM   1605 C  CA  . ASP   A 1 210 ? -28.962 -61.519  -41.734 1.00 89.91  ? 211  ASP   A CA  1 
ATOM   1606 C  C   . ASP   A 1 210 ? -27.993 -62.174  -40.746 1.00 86.00  ? 211  ASP   A C   1 
ATOM   1607 O  O   . ASP   A 1 210 ? -27.027 -61.499  -40.338 1.00 82.88  ? 211  ASP   A O   1 
ATOM   1608 C  CB  . ASP   A 1 210 ? -28.259 -61.106  -43.030 1.00 92.28  ? 211  ASP   A CB  1 
ATOM   1609 C  CG  . ASP   A 1 210 ? -29.227 -60.788  -44.154 1.00 97.63  ? 211  ASP   A CG  1 
ATOM   1610 O  OD1 . ASP   A 1 210 ? -29.990 -61.697  -44.541 1.00 97.99  ? 211  ASP   A OD1 1 
ATOM   1611 O  OD2 . ASP   A 1 210 ? -29.222 -59.632  -44.622 1.00 103.55 ? 211  ASP   A OD2 1 
ATOM   1612 N  N   . LEU   A 1 211 ? -28.262 -63.424  -40.358 1.00 83.31  ? 212  LEU   A N   1 
ATOM   1613 C  CA  . LEU   A 1 211 ? -27.312 -64.258  -39.578 1.00 84.63  ? 212  LEU   A CA  1 
ATOM   1614 C  C   . LEU   A 1 211 ? -26.110 -64.553  -40.464 1.00 90.56  ? 212  LEU   A C   1 
ATOM   1615 O  O   . LEU   A 1 211 ? -26.237 -64.616  -41.686 1.00 90.14  ? 212  LEU   A O   1 
ATOM   1616 C  CB  . LEU   A 1 211 ? -27.973 -65.568  -39.134 1.00 82.91  ? 212  LEU   A CB  1 
ATOM   1617 C  CG  . LEU   A 1 211 ? -29.092 -65.460  -38.099 1.00 85.15  ? 212  LEU   A CG  1 
ATOM   1618 C  CD1 . LEU   A 1 211 ? -29.466 -66.841  -37.583 1.00 84.66  ? 212  LEU   A CD1 1 
ATOM   1619 C  CD2 . LEU   A 1 211 ? -28.706 -64.552  -36.939 1.00 85.01  ? 212  LEU   A CD2 1 
ATOM   1620 N  N   . PRO   A 1 212 ? -24.912 -64.750  -39.871 1.00 94.36  ? 213  PRO   A N   1 
ATOM   1621 C  CA  . PRO   A 1 212 ? -23.750 -65.208  -40.625 1.00 93.09  ? 213  PRO   A CA  1 
ATOM   1622 C  C   . PRO   A 1 212 ? -23.821 -66.731  -40.799 1.00 92.85  ? 213  PRO   A C   1 
ATOM   1623 O  O   . PRO   A 1 212 ? -24.790 -67.325  -40.344 1.00 83.53  ? 213  PRO   A O   1 
ATOM   1624 C  CB  . PRO   A 1 212 ? -22.590 -64.789  -39.715 1.00 95.40  ? 213  PRO   A CB  1 
ATOM   1625 C  CG  . PRO   A 1 212 ? -23.157 -64.972  -38.322 1.00 94.80  ? 213  PRO   A CG  1 
ATOM   1626 C  CD  . PRO   A 1 212 ? -24.615 -64.571  -38.440 1.00 93.75  ? 213  PRO   A CD  1 
ATOM   1627 N  N   . SER   A 1 213 ? -22.799 -67.315  -41.432 1.00 93.97  ? 214  SER   A N   1 
ATOM   1628 C  CA  . SER   A 1 213 ? -22.566 -68.781  -41.511 1.00 92.84  ? 214  SER   A CA  1 
ATOM   1629 C  C   . SER   A 1 213 ? -22.645 -69.388  -40.105 1.00 88.68  ? 214  SER   A C   1 
ATOM   1630 O  O   . SER   A 1 213 ? -22.449 -68.643  -39.127 1.00 91.14  ? 214  SER   A O   1 
ATOM   1631 C  CB  . SER   A 1 213 ? -21.242 -69.081  -42.160 1.00 94.70  ? 214  SER   A CB  1 
ATOM   1632 O  OG  . SER   A 1 213 ? -21.276 -68.772  -43.544 1.00 97.31  ? 214  SER   A OG  1 
ATOM   1633 N  N   . ASN   A 1 214 ? -22.929 -70.689  -40.009 1.00 84.88  ? 215  ASN   A N   1 
ATOM   1634 C  CA  . ASN   A 1 214 ? -23.068 -71.407  -38.715 1.00 84.78  ? 215  ASN   A CA  1 
ATOM   1635 C  C   . ASN   A 1 214 ? -21.736 -71.366  -37.964 1.00 83.64  ? 215  ASN   A C   1 
ATOM   1636 O  O   . ASN   A 1 214 ? -21.778 -71.254  -36.727 1.00 81.19  ? 215  ASN   A O   1 
ATOM   1637 C  CB  . ASN   A 1 214 ? -23.550 -72.846  -38.902 1.00 88.29  ? 215  ASN   A CB  1 
ATOM   1638 C  CG  . ASN   A 1 214 ? -25.019 -72.927  -39.259 1.00 93.58  ? 215  ASN   A CG  1 
ATOM   1639 O  OD1 . ASN   A 1 214 ? -25.745 -71.939  -39.166 1.00 93.61  ? 215  ASN   A OD1 1 
ATOM   1640 N  ND2 . ASN   A 1 214 ? -25.469 -74.103  -39.664 1.00 99.74  ? 215  ASN   A ND2 1 
ATOM   1641 N  N   . HIS   A 1 215 ? -20.608 -71.439  -38.681 1.00 84.40  ? 216  HIS   A N   1 
ATOM   1642 C  CA  . HIS   A 1 215 ? -19.244 -71.464  -38.085 1.00 84.71  ? 216  HIS   A CA  1 
ATOM   1643 C  C   . HIS   A 1 215 ? -19.050 -70.211  -37.220 1.00 84.01  ? 216  HIS   A C   1 
ATOM   1644 O  O   . HIS   A 1 215 ? -18.478 -70.347  -36.121 1.00 89.27  ? 216  HIS   A O   1 
ATOM   1645 C  CB  . HIS   A 1 215 ? -18.158 -71.690  -39.158 1.00 84.32  ? 216  HIS   A CB  1 
ATOM   1646 C  CG  . HIS   A 1 215 ? -17.872 -70.531  -40.058 1.00 84.45  ? 216  HIS   A CG  1 
ATOM   1647 N  ND1 . HIS   A 1 215 ? -17.003 -69.514  -39.708 1.00 83.75  ? 216  HIS   A ND1 1 
ATOM   1648 C  CD2 . HIS   A 1 215 ? -18.284 -70.254  -41.314 1.00 82.55  ? 216  HIS   A CD2 1 
ATOM   1649 C  CE1 . HIS   A 1 215 ? -16.916 -68.650  -40.698 1.00 80.40  ? 216  HIS   A CE1 1 
ATOM   1650 N  NE2 . HIS   A 1 215 ? -17.694 -69.078  -41.694 1.00 80.22  ? 216  HIS   A NE2 1 
ATOM   1651 N  N   . VAL   A 1 216 ? -19.568 -69.063  -37.671 1.00 81.94  ? 217  VAL   A N   1 
ATOM   1652 C  CA  . VAL   A 1 216 ? -19.505 -67.750  -36.958 1.00 78.77  ? 217  VAL   A CA  1 
ATOM   1653 C  C   . VAL   A 1 216 ? -20.347 -67.843  -35.675 1.00 79.86  ? 217  VAL   A C   1 
ATOM   1654 O  O   . VAL   A 1 216 ? -19.852 -67.396  -34.624 1.00 87.33  ? 217  VAL   A O   1 
ATOM   1655 C  CB  . VAL   A 1 216 ? -19.961 -66.587  -37.866 1.00 78.51  ? 217  VAL   A CB  1 
ATOM   1656 C  CG1 . VAL   A 1 216 ? -20.000 -65.257  -37.124 1.00 80.34  ? 217  VAL   A CG1 1 
ATOM   1657 C  CG2 . VAL   A 1 216 ? -19.097 -66.465  -39.115 1.00 75.05  ? 217  VAL   A CG2 1 
ATOM   1658 N  N   . ILE   A 1 217 ? -21.562 -68.403  -35.752 1.00 75.99  ? 218  ILE   A N   1 
ATOM   1659 C  CA  . ILE   A 1 217 ? -22.468 -68.616  -34.579 1.00 76.34  ? 218  ILE   A CA  1 
ATOM   1660 C  C   . ILE   A 1 217 ? -21.836 -69.676  -33.666 1.00 76.92  ? 218  ILE   A C   1 
ATOM   1661 O  O   . ILE   A 1 217 ? -22.032 -69.601  -32.437 1.00 79.55  ? 218  ILE   A O   1 
ATOM   1662 C  CB  . ILE   A 1 217 ? -23.894 -69.017  -35.024 1.00 75.84  ? 218  ILE   A CB  1 
ATOM   1663 C  CG1 . ILE   A 1 217 ? -24.536 -67.958  -35.925 1.00 77.88  ? 218  ILE   A CG1 1 
ATOM   1664 C  CG2 . ILE   A 1 217 ? -24.782 -69.331  -33.825 1.00 71.35  ? 218  ILE   A CG2 1 
ATOM   1665 C  CD1 . ILE   A 1 217 ? -25.729 -68.460  -36.710 1.00 78.19  ? 218  ILE   A CD1 1 
ATOM   1666 N  N   . ASP   A 1 218 ? -21.111 -70.631  -34.254 1.00 76.93  ? 219  ASP   A N   1 
ATOM   1667 C  CA  . ASP   A 1 218 ? -20.469 -71.765  -33.538 1.00 77.74  ? 219  ASP   A CA  1 
ATOM   1668 C  C   . ASP   A 1 218 ? -19.271 -71.263  -32.716 1.00 74.55  ? 219  ASP   A C   1 
ATOM   1669 O  O   . ASP   A 1 218 ? -18.956 -71.905  -31.693 1.00 65.55  ? 219  ASP   A O   1 
ATOM   1670 C  CB  . ASP   A 1 218 ? -20.086 -72.878  -34.517 1.00 79.77  ? 219  ASP   A CB  1 
ATOM   1671 C  CG  . ASP   A 1 218 ? -21.264 -73.735  -34.955 1.00 82.33  ? 219  ASP   A CG  1 
ATOM   1672 O  OD1 . ASP   A 1 218 ? -22.393 -73.466  -34.490 1.00 80.90  ? 219  ASP   A OD1 1 
ATOM   1673 O  OD2 . ASP   A 1 218 ? -21.043 -74.665  -35.756 1.00 84.84  ? 219  ASP   A OD2 1 
ATOM   1674 N  N   . ARG   A 1 219 ? -18.632 -70.159  -33.122 1.00 72.31  ? 220  ARG   A N   1 
ATOM   1675 C  CA  . ARG   A 1 219 ? -17.502 -69.546  -32.369 1.00 74.31  ? 220  ARG   A CA  1 
ATOM   1676 C  C   . ARG   A 1 219 ? -17.943 -69.184  -30.942 1.00 75.91  ? 220  ARG   A C   1 
ATOM   1677 O  O   . ARG   A 1 219 ? -17.095 -69.273  -30.034 1.00 82.69  ? 220  ARG   A O   1 
ATOM   1678 C  CB  . ARG   A 1 219 ? -16.964 -68.298  -33.077 1.00 72.90  ? 220  ARG   A CB  1 
ATOM   1679 C  CG  . ARG   A 1 219 ? -16.112 -68.577  -34.306 1.00 72.40  ? 220  ARG   A CG  1 
ATOM   1680 C  CD  . ARG   A 1 219 ? -15.133 -69.706  -34.084 1.00 77.92  ? 220  ARG   A CD  1 
ATOM   1681 N  NE  . ARG   A 1 219 ? -14.239 -69.488  -32.958 1.00 84.06  ? 220  ARG   A NE  1 
ATOM   1682 C  CZ  . ARG   A 1 219 ? -13.055 -68.887  -33.036 1.00 86.78  ? 220  ARG   A CZ  1 
ATOM   1683 N  NH1 . ARG   A 1 219 ? -12.314 -68.765  -31.950 1.00 85.03  ? 220  ARG   A NH1 1 
ATOM   1684 N  NH2 . ARG   A 1 219 ? -12.610 -68.405  -34.186 1.00 86.87  ? 220  ARG   A NH2 1 
ATOM   1685 N  N   . TRP   A 1 220 ? -19.212 -68.798  -30.758 1.00 70.71  ? 221  TRP   A N   1 
ATOM   1686 C  CA  . TRP   A 1 220 ? -19.774 -68.281  -29.481 1.00 67.05  ? 221  TRP   A CA  1 
ATOM   1687 C  C   . TRP   A 1 220 ? -20.228 -69.429  -28.577 1.00 66.59  ? 221  TRP   A C   1 
ATOM   1688 O  O   . TRP   A 1 220 ? -20.640 -69.145  -27.435 1.00 63.79  ? 221  TRP   A O   1 
ATOM   1689 C  CB  . TRP   A 1 220 ? -20.914 -67.295  -29.758 1.00 64.33  ? 221  TRP   A CB  1 
ATOM   1690 C  CG  . TRP   A 1 220 ? -20.444 -66.105  -30.529 1.00 61.61  ? 221  TRP   A CG  1 
ATOM   1691 C  CD1 . TRP   A 1 220 ? -20.565 -65.896  -31.870 1.00 61.32  ? 221  TRP   A CD1 1 
ATOM   1692 C  CD2 . TRP   A 1 220 ? -19.703 -64.990  -30.011 1.00 57.86  ? 221  TRP   A CD2 1 
ATOM   1693 N  NE1 . TRP   A 1 220 ? -19.975 -64.713  -32.217 1.00 59.92  ? 221  TRP   A NE1 1 
ATOM   1694 C  CE2 . TRP   A 1 220 ? -19.436 -64.134  -31.099 1.00 59.14  ? 221  TRP   A CE2 1 
ATOM   1695 C  CE3 . TRP   A 1 220 ? -19.249 -64.629  -28.739 1.00 58.03  ? 221  TRP   A CE3 1 
ATOM   1696 C  CZ2 . TRP   A 1 220 ? -18.741 -62.935  -30.949 1.00 59.49  ? 221  TRP   A CZ2 1 
ATOM   1697 C  CZ3 . TRP   A 1 220 ? -18.565 -63.443  -28.590 1.00 60.14  ? 221  TRP   A CZ3 1 
ATOM   1698 C  CH2 . TRP   A 1 220 ? -18.318 -62.607  -29.681 1.00 60.67  ? 221  TRP   A CH2 1 
ATOM   1699 N  N   . LEU   A 1 221 ? -20.170 -70.667  -29.070 1.00 70.81  ? 222  LEU   A N   1 
ATOM   1700 C  CA  . LEU   A 1 221 ? -20.320 -71.886  -28.231 1.00 72.64  ? 222  LEU   A CA  1 
ATOM   1701 C  C   . LEU   A 1 221 ? -19.214 -71.881  -27.173 1.00 68.68  ? 222  LEU   A C   1 
ATOM   1702 O  O   . LEU   A 1 221 ? -18.046 -71.607  -27.538 1.00 65.68  ? 222  LEU   A O   1 
ATOM   1703 C  CB  . LEU   A 1 221 ? -20.242 -73.140  -29.106 1.00 76.27  ? 222  LEU   A CB  1 
ATOM   1704 C  CG  . LEU   A 1 221 ? -21.443 -73.380  -30.017 1.00 80.65  ? 222  LEU   A CG  1 
ATOM   1705 C  CD1 . LEU   A 1 221 ? -21.092 -74.332  -31.154 1.00 79.33  ? 222  LEU   A CD1 1 
ATOM   1706 C  CD2 . LEU   A 1 221 ? -22.621 -73.914  -29.213 1.00 83.96  ? 222  LEU   A CD2 1 
ATOM   1707 N  N   . GLY   A 1 222 ? -19.588 -72.128  -25.914 1.00 64.39  ? 223  GLY   A N   1 
ATOM   1708 C  CA  . GLY   A 1 222 ? -18.662 -72.192  -24.768 1.00 62.98  ? 223  GLY   A CA  1 
ATOM   1709 C  C   . GLY   A 1 222 ? -18.394 -70.831  -24.144 1.00 60.16  ? 223  GLY   A C   1 
ATOM   1710 O  O   . GLY   A 1 222 ? -17.848 -70.808  -23.023 1.00 66.03  ? 223  GLY   A O   1 
ATOM   1711 N  N   . GLU   A 1 223 ? -18.756 -69.736  -24.824 1.00 58.78  ? 224  GLU   A N   1 
ATOM   1712 C  CA  . GLU   A 1 223 ? -18.518 -68.347  -24.344 1.00 57.35  ? 224  GLU   A CA  1 
ATOM   1713 C  C   . GLU   A 1 223 ? -19.573 -67.980  -23.306 1.00 56.52  ? 224  GLU   A C   1 
ATOM   1714 O  O   . GLU   A 1 223 ? -20.693 -68.483  -23.352 1.00 57.72  ? 224  GLU   A O   1 
ATOM   1715 C  CB  . GLU   A 1 223 ? -18.538 -67.353  -25.504 1.00 56.54  ? 224  GLU   A CB  1 
ATOM   1716 C  CG  . GLU   A 1 223 ? -17.434 -67.588  -26.519 1.00 55.71  ? 224  GLU   A CG  1 
ATOM   1717 C  CD  . GLU   A 1 223 ? -16.035 -67.534  -25.938 1.00 52.11  ? 224  GLU   A CD  1 
ATOM   1718 O  OE1 . GLU   A 1 223 ? -15.885 -66.971  -24.851 1.00 49.24  ? 224  GLU   A OE1 1 
ATOM   1719 O  OE2 . GLU   A 1 223 ? -15.108 -68.064  -26.571 1.00 52.87  ? 224  GLU   A OE2 1 
ATOM   1720 N  N   . PRO   A 1 224 ? -19.236 -67.108  -22.331 1.00 55.98  ? 225  PRO   A N   1 
ATOM   1721 C  CA  . PRO   A 1 224 ? -20.180 -66.706  -21.288 1.00 55.17  ? 225  PRO   A CA  1 
ATOM   1722 C  C   . PRO   A 1 224 ? -21.197 -65.673  -21.793 1.00 55.22  ? 225  PRO   A C   1 
ATOM   1723 O  O   . PRO   A 1 224 ? -21.072 -64.511  -21.471 1.00 57.14  ? 225  PRO   A O   1 
ATOM   1724 C  CB  . PRO   A 1 224 ? -19.251 -66.123  -20.216 1.00 53.88  ? 225  PRO   A CB  1 
ATOM   1725 C  CG  . PRO   A 1 224 ? -18.129 -65.508  -21.019 1.00 54.92  ? 225  PRO   A CG  1 
ATOM   1726 C  CD  . PRO   A 1 224 ? -17.916 -66.476  -22.164 1.00 55.76  ? 225  PRO   A CD  1 
ATOM   1727 N  N   . ILE   A 1 225 ? -22.176 -66.127  -22.573 1.00 54.89  ? 226  ILE   A N   1 
ATOM   1728 C  CA  . ILE   A 1 225 ? -23.307 -65.282  -23.052 1.00 58.00  ? 226  ILE   A CA  1 
ATOM   1729 C  C   . ILE   A 1 225 ? -24.329 -65.200  -21.914 1.00 57.47  ? 226  ILE   A C   1 
ATOM   1730 O  O   . ILE   A 1 225 ? -24.906 -66.246  -21.549 1.00 55.93  ? 226  ILE   A O   1 
ATOM   1731 C  CB  . ILE   A 1 225 ? -23.915 -65.828  -24.362 1.00 59.68  ? 226  ILE   A CB  1 
ATOM   1732 C  CG1 . ILE   A 1 225 ? -22.846 -66.063  -25.433 1.00 61.50  ? 226  ILE   A CG1 1 
ATOM   1733 C  CG2 . ILE   A 1 225 ? -25.011 -64.900  -24.871 1.00 59.55  ? 226  ILE   A CG2 1 
ATOM   1734 C  CD1 . ILE   A 1 225 ? -23.334 -66.845  -26.628 1.00 63.94  ? 226  ILE   A CD1 1 
ATOM   1735 N  N   . LYS   A 1 226 ? -24.516 -64.004  -21.359 1.00 59.36  ? 227  LYS   A N   1 
ATOM   1736 C  CA  . LYS   A 1 226 ? -25.510 -63.730  -20.291 1.00 64.16  ? 227  LYS   A CA  1 
ATOM   1737 C  C   . LYS   A 1 226 ? -26.758 -63.085  -20.904 1.00 63.32  ? 227  LYS   A C   1 
ATOM   1738 O  O   . LYS   A 1 226 ? -27.844 -63.238  -20.303 1.00 62.95  ? 227  LYS   A O   1 
ATOM   1739 C  CB  . LYS   A 1 226 ? -24.891 -62.862  -19.190 1.00 66.34  ? 227  LYS   A CB  1 
ATOM   1740 C  CG  . LYS   A 1 226 ? -24.017 -63.617  -18.196 1.00 70.45  ? 227  LYS   A CG  1 
ATOM   1741 C  CD  . LYS   A 1 226 ? -24.769 -64.666  -17.391 1.00 76.34  ? 227  LYS   A CD  1 
ATOM   1742 C  CE  . LYS   A 1 226 ? -23.862 -65.574  -16.585 1.00 81.91  ? 227  LYS   A CE  1 
ATOM   1743 N  NZ  . LYS   A 1 226 ? -24.487 -66.895  -16.332 1.00 80.86  ? 227  LYS   A NZ  1 
ATOM   1744 N  N   . ALA   A 1 227 ? -26.615 -62.408  -22.050 1.00 61.73  ? 228  ALA   A N   1 
ATOM   1745 C  CA  . ALA   A 1 227 ? -27.705 -61.659  -22.717 1.00 61.22  ? 228  ALA   A CA  1 
ATOM   1746 C  C   . ALA   A 1 227 ? -27.614 -61.809  -24.236 1.00 63.52  ? 228  ALA   A C   1 
ATOM   1747 O  O   . ALA   A 1 227 ? -26.488 -61.900  -24.758 1.00 67.73  ? 228  ALA   A O   1 
ATOM   1748 C  CB  . ALA   A 1 227 ? -27.652 -60.208  -22.317 1.00 59.57  ? 228  ALA   A CB  1 
ATOM   1749 N  N   . ALA   A 1 228 ? -28.772 -61.840  -24.902 1.00 64.62  ? 229  ALA   A N   1 
ATOM   1750 C  CA  . ALA   A 1 228 ? -28.929 -61.756  -26.373 1.00 64.24  ? 229  ALA   A CA  1 
ATOM   1751 C  C   . ALA   A 1 228 ? -29.812 -60.547  -26.698 1.00 62.10  ? 229  ALA   A C   1 
ATOM   1752 O  O   . ALA   A 1 228 ? -30.909 -60.450  -26.124 1.00 61.88  ? 229  ALA   A O   1 
ATOM   1753 C  CB  . ALA   A 1 228 ? -29.519 -63.035  -26.910 1.00 63.60  ? 229  ALA   A CB  1 
ATOM   1754 N  N   . ILE   A 1 229 ? -29.331 -59.650  -27.559 1.00 62.98  ? 230  ILE   A N   1 
ATOM   1755 C  CA  . ILE   A 1 229 ? -30.020 -58.376  -27.924 1.00 63.98  ? 230  ILE   A CA  1 
ATOM   1756 C  C   . ILE   A 1 229 ? -30.705 -58.572  -29.281 1.00 64.75  ? 230  ILE   A C   1 
ATOM   1757 O  O   . ILE   A 1 229 ? -29.986 -58.817  -30.270 1.00 63.56  ? 230  ILE   A O   1 
ATOM   1758 C  CB  . ILE   A 1 229 ? -29.023 -57.200  -27.921 1.00 62.10  ? 230  ILE   A CB  1 
ATOM   1759 C  CG1 . ILE   A 1 229 ? -28.509 -56.916  -26.506 1.00 63.52  ? 230  ILE   A CG1 1 
ATOM   1760 C  CG2 . ILE   A 1 229 ? -29.640 -55.962  -28.555 1.00 61.82  ? 230  ILE   A CG2 1 
ATOM   1761 C  CD1 . ILE   A 1 229 ? -27.318 -55.983  -26.448 1.00 63.39  ? 230  ILE   A CD1 1 
ATOM   1762 N  N   . LEU   A 1 230 ? -32.041 -58.489  -29.306 1.00 67.22  ? 231  LEU   A N   1 
ATOM   1763 C  CA  . LEU   A 1 230 ? -32.892 -58.607  -30.525 1.00 67.37  ? 231  LEU   A CA  1 
ATOM   1764 C  C   . LEU   A 1 230 ? -33.405 -57.218  -30.899 1.00 65.23  ? 231  LEU   A C   1 
ATOM   1765 O  O   . LEU   A 1 230 ? -34.286 -56.690  -30.226 1.00 66.23  ? 231  LEU   A O   1 
ATOM   1766 C  CB  . LEU   A 1 230 ? -34.059 -59.561  -30.241 1.00 65.36  ? 231  LEU   A CB  1 
ATOM   1767 C  CG  . LEU   A 1 230 ? -33.710 -60.832  -29.468 1.00 65.84  ? 231  LEU   A CG  1 
ATOM   1768 C  CD1 . LEU   A 1 230 ? -34.965 -61.618  -29.132 1.00 66.92  ? 231  LEU   A CD1 1 
ATOM   1769 C  CD2 . LEU   A 1 230 ? -32.729 -61.697  -30.245 1.00 65.51  ? 231  LEU   A CD2 1 
ATOM   1770 N  N   . PRO   A 1 231 ? -32.860 -56.553  -31.944 1.00 67.79  ? 232  PRO   A N   1 
ATOM   1771 C  CA  . PRO   A 1 231 ? -33.438 -55.304  -32.433 1.00 68.92  ? 232  PRO   A CA  1 
ATOM   1772 C  C   . PRO   A 1 231 ? -34.812 -55.581  -33.055 1.00 68.09  ? 232  PRO   A C   1 
ATOM   1773 O  O   . PRO   A 1 231 ? -34.956 -56.592  -33.709 1.00 68.52  ? 232  PRO   A O   1 
ATOM   1774 C  CB  . PRO   A 1 231 ? -32.446 -54.788  -33.487 1.00 68.49  ? 232  PRO   A CB  1 
ATOM   1775 C  CG  . PRO   A 1 231 ? -31.186 -55.598  -33.255 1.00 68.34  ? 232  PRO   A CG  1 
ATOM   1776 C  CD  . PRO   A 1 231 ? -31.656 -56.928  -32.697 1.00 68.36  ? 232  PRO   A CD  1 
ATOM   1777 N  N   . THR   A 1 232 ? -35.777 -54.693  -32.815 1.00 71.21  ? 233  THR   A N   1 
ATOM   1778 C  CA  . THR   A 1 232 ? -37.144 -54.741  -33.401 1.00 71.27  ? 233  THR   A CA  1 
ATOM   1779 C  C   . THR   A 1 232 ? -37.046 -55.015  -34.908 1.00 75.49  ? 233  THR   A C   1 
ATOM   1780 O  O   . THR   A 1 232 ? -37.823 -55.852  -35.407 1.00 76.76  ? 233  THR   A O   1 
ATOM   1781 C  CB  . THR   A 1 232 ? -37.905 -53.444  -33.101 1.00 68.65  ? 233  THR   A CB  1 
ATOM   1782 O  OG1 . THR   A 1 232 ? -37.037 -52.338  -33.362 1.00 67.33  ? 233  THR   A OG1 1 
ATOM   1783 C  CG2 . THR   A 1 232 ? -38.397 -53.382  -31.672 1.00 68.61  ? 233  THR   A CG2 1 
ATOM   1784 N  N   . SER   A 1 233 ? -36.092 -54.366  -35.585 1.00 77.57  ? 234  SER   A N   1 
ATOM   1785 C  CA  . SER   A 1 233 ? -35.926 -54.354  -37.063 1.00 79.46  ? 234  SER   A CA  1 
ATOM   1786 C  C   . SER   A 1 233 ? -35.883 -55.776  -37.649 1.00 80.34  ? 234  SER   A C   1 
ATOM   1787 O  O   . SER   A 1 233 ? -36.436 -55.962  -38.748 1.00 87.34  ? 234  SER   A O   1 
ATOM   1788 C  CB  . SER   A 1 233 ? -34.701 -53.562  -37.452 1.00 80.71  ? 234  SER   A CB  1 
ATOM   1789 O  OG  . SER   A 1 233 ? -33.514 -54.293  -37.183 1.00 82.52  ? 234  SER   A OG  1 
ATOM   1790 N  N   . ILE   A 1 234 ? -35.265 -56.742  -36.958 1.00 82.76  ? 235  ILE   A N   1 
ATOM   1791 C  CA  . ILE   A 1 234 ? -34.944 -58.094  -37.518 1.00 82.88  ? 235  ILE   A CA  1 
ATOM   1792 C  C   . ILE   A 1 234 ? -36.196 -58.979  -37.519 1.00 80.15  ? 235  ILE   A C   1 
ATOM   1793 O  O   . ILE   A 1 234 ? -36.153 -60.049  -38.160 1.00 78.89  ? 235  ILE   A O   1 
ATOM   1794 C  CB  . ILE   A 1 234 ? -33.784 -58.776  -36.761 1.00 83.22  ? 235  ILE   A CB  1 
ATOM   1795 C  CG1 . ILE   A 1 234 ? -34.203 -59.257  -35.368 1.00 85.10  ? 235  ILE   A CG1 1 
ATOM   1796 C  CG2 . ILE   A 1 234 ? -32.566 -57.866  -36.709 1.00 85.82  ? 235  ILE   A CG2 1 
ATOM   1797 C  CD1 . ILE   A 1 234 ? -33.204 -60.175  -34.708 1.00 87.33  ? 235  ILE   A CD1 1 
ATOM   1798 N  N   . PHE   A 1 235 ? -37.248 -58.579  -36.802 1.00 81.58  ? 236  PHE   A N   1 
ATOM   1799 C  CA  . PHE   A 1 235 ? -38.545 -59.303  -36.766 1.00 83.11  ? 236  PHE   A CA  1 
ATOM   1800 C  C   . PHE   A 1 235 ? -39.233 -59.139  -38.126 1.00 85.13  ? 236  PHE   A C   1 
ATOM   1801 O  O   . PHE   A 1 235 ? -39.339 -57.996  -38.619 1.00 79.99  ? 236  PHE   A O   1 
ATOM   1802 C  CB  . PHE   A 1 235 ? -39.424 -58.810  -35.611 1.00 81.23  ? 236  PHE   A CB  1 
ATOM   1803 C  CG  . PHE   A 1 235 ? -38.961 -59.242  -34.243 1.00 80.13  ? 236  PHE   A CG  1 
ATOM   1804 C  CD1 . PHE   A 1 235 ? -37.931 -58.575  -33.594 1.00 82.80  ? 236  PHE   A CD1 1 
ATOM   1805 C  CD2 . PHE   A 1 235 ? -39.547 -60.322  -33.601 1.00 77.97  ? 236  PHE   A CD2 1 
ATOM   1806 C  CE1 . PHE   A 1 235 ? -37.499 -58.976  -32.339 1.00 77.90  ? 236  PHE   A CE1 1 
ATOM   1807 C  CE2 . PHE   A 1 235 ? -39.114 -60.722  -32.345 1.00 79.13  ? 236  PHE   A CE2 1 
ATOM   1808 C  CZ  . PHE   A 1 235 ? -38.092 -60.048  -31.716 1.00 77.61  ? 236  PHE   A CZ  1 
ATOM   1809 N  N   . LEU   A 1 236 ? -39.640 -60.260  -38.727 1.00 89.95  ? 237  LEU   A N   1 
ATOM   1810 C  CA  . LEU   A 1 236 ? -40.546 -60.307  -39.905 1.00 95.42  ? 237  LEU   A CA  1 
ATOM   1811 C  C   . LEU   A 1 236 ? -41.980 -60.120  -39.392 1.00 102.35 ? 237  LEU   A C   1 
ATOM   1812 O  O   . LEU   A 1 236 ? -42.161 -60.158  -38.154 1.00 99.12  ? 237  LEU   A O   1 
ATOM   1813 C  CB  . LEU   A 1 236 ? -40.367 -61.648  -40.625 1.00 92.88  ? 237  LEU   A CB  1 
ATOM   1814 C  CG  . LEU   A 1 236 ? -38.941 -61.968  -41.074 1.00 91.81  ? 237  LEU   A CG  1 
ATOM   1815 C  CD1 . LEU   A 1 236 ? -38.824 -63.413  -41.537 1.00 89.96  ? 237  LEU   A CD1 1 
ATOM   1816 C  CD2 . LEU   A 1 236 ? -38.490 -61.015  -42.169 1.00 94.33  ? 237  LEU   A CD2 1 
ATOM   1817 N  N   . THR   A 1 237 ? -42.958 -59.914  -40.282 1.00 110.35 ? 238  THR   A N   1 
ATOM   1818 C  CA  . THR   A 1 237 ? -44.381 -59.722  -39.889 1.00 114.17 ? 238  THR   A CA  1 
ATOM   1819 C  C   . THR   A 1 237 ? -45.247 -60.891  -40.370 1.00 119.20 ? 238  THR   A C   1 
ATOM   1820 O  O   . THR   A 1 237 ? -45.174 -61.248  -41.564 1.00 117.31 ? 238  THR   A O   1 
ATOM   1821 C  CB  . THR   A 1 237 ? -44.965 -58.395  -40.385 1.00 114.73 ? 238  THR   A CB  1 
ATOM   1822 O  OG1 . THR   A 1 237 ? -43.984 -57.367  -40.250 1.00 117.48 ? 238  THR   A OG1 1 
ATOM   1823 C  CG2 . THR   A 1 237 ? -46.216 -58.025  -39.616 1.00 115.84 ? 238  THR   A CG2 1 
ATOM   1824 N  N   . ASN   A 1 238 ? -46.038 -61.443  -39.445 1.00 125.51 ? 239  ASN   A N   1 
ATOM   1825 C  CA  . ASN   A 1 238 ? -47.150 -62.396  -39.695 1.00 129.20 ? 239  ASN   A CA  1 
ATOM   1826 C  C   . ASN   A 1 238 ? -48.226 -61.664  -40.504 1.00 134.71 ? 239  ASN   A C   1 
ATOM   1827 O  O   . ASN   A 1 238 ? -48.388 -60.444  -40.296 1.00 135.91 ? 239  ASN   A O   1 
ATOM   1828 C  CB  . ASN   A 1 238 ? -47.704 -62.932  -38.371 1.00 130.32 ? 239  ASN   A CB  1 
ATOM   1829 C  CG  . ASN   A 1 238 ? -48.676 -64.084  -38.521 1.00 134.21 ? 239  ASN   A CG  1 
ATOM   1830 O  OD1 . ASN   A 1 238 ? -49.071 -64.441  -39.629 1.00 141.91 ? 239  ASN   A OD1 1 
ATOM   1831 N  ND2 . ASN   A 1 238 ? -49.070 -64.672  -37.402 1.00 132.32 ? 239  ASN   A ND2 1 
ATOM   1832 N  N   . LYS   A 1 239 ? -48.940 -62.378  -41.380 1.00 137.65 ? 240  LYS   A N   1 
ATOM   1833 C  CA  . LYS   A 1 239 ? -50.013 -61.799  -42.235 1.00 137.73 ? 240  LYS   A CA  1 
ATOM   1834 C  C   . LYS   A 1 239 ? -51.077 -61.145  -41.343 1.00 136.72 ? 240  LYS   A C   1 
ATOM   1835 O  O   . LYS   A 1 239 ? -51.620 -60.101  -41.756 1.00 139.61 ? 240  LYS   A O   1 
ATOM   1836 C  CB  . LYS   A 1 239 ? -50.606 -62.865  -43.162 1.00 136.83 ? 240  LYS   A CB  1 
ATOM   1837 C  CG  . LYS   A 1 239 ? -49.689 -63.287  -44.304 1.00 134.85 ? 240  LYS   A CG  1 
ATOM   1838 C  CD  . LYS   A 1 239 ? -50.417 -63.818  -45.519 1.00 133.91 ? 240  LYS   A CD  1 
ATOM   1839 C  CE  . LYS   A 1 239 ? -49.485 -64.095  -46.679 1.00 133.08 ? 240  LYS   A CE  1 
ATOM   1840 N  NZ  . LYS   A 1 239 ? -50.227 -64.476  -47.904 1.00 131.64 ? 240  LYS   A NZ  1 
ATOM   1841 N  N   . LYS   A 1 240 ? -51.341 -61.722  -40.165 1.00 132.00 ? 241  LYS   A N   1 
ATOM   1842 C  CA  . LYS   A 1 240 ? -52.265 -61.163  -39.139 1.00 131.71 ? 241  LYS   A CA  1 
ATOM   1843 C  C   . LYS   A 1 240 ? -51.708 -59.838  -38.603 1.00 134.71 ? 241  LYS   A C   1 
ATOM   1844 O  O   . LYS   A 1 240 ? -52.520 -58.933  -38.329 1.00 137.72 ? 241  LYS   A O   1 
ATOM   1845 C  CB  . LYS   A 1 240 ? -52.476 -62.159  -37.997 1.00 131.64 ? 241  LYS   A CB  1 
ATOM   1846 C  CG  . LYS   A 1 240 ? -53.200 -63.439  -38.390 1.00 132.30 ? 241  LYS   A CG  1 
ATOM   1847 C  CD  . LYS   A 1 240 ? -53.806 -64.167  -37.213 1.00 131.92 ? 241  LYS   A CD  1 
ATOM   1848 C  CE  . LYS   A 1 240 ? -54.609 -65.382  -37.623 1.00 131.69 ? 241  LYS   A CE  1 
ATOM   1849 N  NZ  . LYS   A 1 240 ? -55.390 -65.924  -36.486 1.00 133.72 ? 241  LYS   A NZ  1 
ATOM   1850 N  N   . GLY   A 1 241 ? -50.384 -59.736  -38.445 1.00 137.19 ? 242  GLY   A N   1 
ATOM   1851 C  CA  . GLY   A 1 241 ? -49.694 -58.477  -38.098 1.00 138.64 ? 242  GLY   A CA  1 
ATOM   1852 C  C   . GLY   A 1 241 ? -48.710 -58.624  -36.948 1.00 138.48 ? 242  GLY   A C   1 
ATOM   1853 O  O   . GLY   A 1 241 ? -47.914 -57.681  -36.755 1.00 132.71 ? 242  GLY   A O   1 
ATOM   1854 N  N   . PHE   A 1 242 ? -48.755 -59.739  -36.206 1.00 140.30 ? 243  PHE   A N   1 
ATOM   1855 C  CA  . PHE   A 1 242 ? -47.849 -60.017  -35.059 1.00 141.45 ? 243  PHE   A CA  1 
ATOM   1856 C  C   . PHE   A 1 242 ? -46.401 -60.050  -35.545 1.00 134.22 ? 243  PHE   A C   1 
ATOM   1857 O  O   . PHE   A 1 242 ? -46.130 -60.485  -36.664 1.00 131.13 ? 243  PHE   A O   1 
ATOM   1858 C  CB  . PHE   A 1 242 ? -48.218 -61.328  -34.352 1.00 147.84 ? 243  PHE   A CB  1 
ATOM   1859 C  CG  . PHE   A 1 242 ? -49.503 -61.305  -33.559 1.00 150.53 ? 243  PHE   A CG  1 
ATOM   1860 C  CD1 . PHE   A 1 242 ? -49.931 -60.153  -32.912 1.00 150.61 ? 243  PHE   A CD1 1 
ATOM   1861 C  CD2 . PHE   A 1 242 ? -50.270 -62.455  -33.426 1.00 148.63 ? 243  PHE   A CD2 1 
ATOM   1862 C  CE1 . PHE   A 1 242 ? -51.106 -60.144  -32.177 1.00 150.15 ? 243  PHE   A CE1 1 
ATOM   1863 C  CE2 . PHE   A 1 242 ? -51.444 -62.444  -32.687 1.00 147.86 ? 243  PHE   A CE2 1 
ATOM   1864 C  CZ  . PHE   A 1 242 ? -51.860 -61.289  -32.065 1.00 149.26 ? 243  PHE   A CZ  1 
ATOM   1865 N  N   . PRO   A 1 243 ? -45.430 -59.582  -34.725 1.00 124.09 ? 244  PRO   A N   1 
ATOM   1866 C  CA  . PRO   A 1 243 ? -44.012 -59.692  -35.061 1.00 116.42 ? 244  PRO   A CA  1 
ATOM   1867 C  C   . PRO   A 1 243 ? -43.549 -61.147  -34.906 1.00 107.71 ? 244  PRO   A C   1 
ATOM   1868 O  O   . PRO   A 1 243 ? -43.968 -61.793  -33.960 1.00 104.22 ? 244  PRO   A O   1 
ATOM   1869 C  CB  . PRO   A 1 243 ? -43.339 -58.775  -34.032 1.00 118.62 ? 244  PRO   A CB  1 
ATOM   1870 C  CG  . PRO   A 1 243 ? -44.245 -58.881  -32.826 1.00 121.93 ? 244  PRO   A CG  1 
ATOM   1871 C  CD  . PRO   A 1 243 ? -45.640 -58.950  -33.412 1.00 123.52 ? 244  PRO   A CD  1 
ATOM   1872 N  N   . VAL   A 1 244 ? -42.711 -61.622  -35.829 1.00 101.02 ? 245  VAL   A N   1 
ATOM   1873 C  CA  . VAL   A 1 244 ? -42.249 -63.041  -35.895 1.00 101.53 ? 245  VAL   A CA  1 
ATOM   1874 C  C   . VAL   A 1 244 ? -40.765 -63.063  -36.271 1.00 98.97  ? 245  VAL   A C   1 
ATOM   1875 O  O   . VAL   A 1 244 ? -40.215 -61.982  -36.578 1.00 95.65  ? 245  VAL   A O   1 
ATOM   1876 C  CB  . VAL   A 1 244 ? -43.104 -63.858  -36.884 1.00 103.69 ? 245  VAL   A CB  1 
ATOM   1877 C  CG1 . VAL   A 1 244 ? -44.427 -64.280  -36.260 1.00 102.39 ? 245  VAL   A CG1 1 
ATOM   1878 C  CG2 . VAL   A 1 244 ? -43.337 -63.112  -38.192 1.00 103.91 ? 245  VAL   A CG2 1 
ATOM   1879 N  N   . LEU   A 1 245 ? -40.148 -64.249  -36.236 1.00 93.78  ? 246  LEU   A N   1 
ATOM   1880 C  CA  . LEU   A 1 245 ? -38.719 -64.458  -36.592 1.00 92.03  ? 246  LEU   A CA  1 
ATOM   1881 C  C   . LEU   A 1 245 ? -38.590 -65.603  -37.602 1.00 89.24  ? 246  LEU   A C   1 
ATOM   1882 O  O   . LEU   A 1 245 ? -39.306 -66.615  -37.447 1.00 82.41  ? 246  LEU   A O   1 
ATOM   1883 C  CB  . LEU   A 1 245 ? -37.926 -64.758  -35.317 1.00 92.22  ? 246  LEU   A CB  1 
ATOM   1884 C  CG  . LEU   A 1 245 ? -37.717 -63.568  -34.384 1.00 91.41  ? 246  LEU   A CG  1 
ATOM   1885 C  CD1 . LEU   A 1 245 ? -37.250 -64.031  -33.013 1.00 90.32  ? 246  LEU   A CD1 1 
ATOM   1886 C  CD2 . LEU   A 1 245 ? -36.729 -62.578  -34.983 1.00 92.01  ? 246  LEU   A CD2 1 
ATOM   1887 N  N   . SER   A 1 246 ? -37.692 -65.435  -38.580 1.00 86.74  ? 247  SER   A N   1 
ATOM   1888 C  CA  . SER   A 1 246 ? -37.297 -66.450  -39.594 1.00 89.31  ? 247  SER   A CA  1 
ATOM   1889 C  C   . SER   A 1 246 ? -36.974 -67.786  -38.914 1.00 89.54  ? 247  SER   A C   1 
ATOM   1890 O  O   . SER   A 1 246 ? -36.597 -67.775  -37.728 1.00 83.83  ? 247  SER   A O   1 
ATOM   1891 C  CB  . SER   A 1 246 ? -36.120 -65.975  -40.407 1.00 91.64  ? 247  SER   A CB  1 
ATOM   1892 O  OG  . SER   A 1 246 ? -34.899 -66.460  -39.865 1.00 95.51  ? 247  SER   A OG  1 
ATOM   1893 N  N   . LYS   A 1 247 ? -37.102 -68.888  -39.657 1.00 99.59  ? 248  LYS   A N   1 
ATOM   1894 C  CA  . LYS   A 1 247 ? -36.784 -70.268  -39.199 1.00 107.53 ? 248  LYS   A CA  1 
ATOM   1895 C  C   . LYS   A 1 247 ? -35.385 -70.293  -38.573 1.00 106.66 ? 248  LYS   A C   1 
ATOM   1896 O  O   . LYS   A 1 247 ? -35.244 -70.856  -37.468 1.00 98.44  ? 248  LYS   A O   1 
ATOM   1897 C  CB  . LYS   A 1 247 ? -36.857 -71.252  -40.372 1.00 113.98 ? 248  LYS   A CB  1 
ATOM   1898 C  CG  . LYS   A 1 247 ? -38.262 -71.634  -40.815 1.00 119.80 ? 248  LYS   A CG  1 
ATOM   1899 C  CD  . LYS   A 1 247 ? -38.906 -72.682  -39.934 1.00 123.65 ? 248  LYS   A CD  1 
ATOM   1900 C  CE  . LYS   A 1 247 ? -40.084 -73.367  -40.595 1.00 126.84 ? 248  LYS   A CE  1 
ATOM   1901 N  NZ  . LYS   A 1 247 ? -40.426 -74.637  -39.911 1.00 131.18 ? 248  LYS   A NZ  1 
ATOM   1902 N  N   . MET   A 1 248 ? -34.398 -69.705  -39.259 1.00 106.01 ? 249  MET   A N   1 
ATOM   1903 C  CA  . MET   A 1 248 ? -32.972 -69.698  -38.833 1.00 102.83 ? 249  MET   A CA  1 
ATOM   1904 C  C   . MET   A 1 248 ? -32.837 -68.934  -37.509 1.00 93.24  ? 249  MET   A C   1 
ATOM   1905 O  O   . MET   A 1 248 ? -32.178 -69.465  -36.596 1.00 91.35  ? 249  MET   A O   1 
ATOM   1906 C  CB  . MET   A 1 248 ? -32.060 -69.088  -39.905 1.00 111.23 ? 249  MET   A CB  1 
ATOM   1907 C  CG  . MET   A 1 248 ? -31.601 -70.101  -40.950 1.00 118.79 ? 249  MET   A CG  1 
ATOM   1908 S  SD  . MET   A 1 248 ? -29.960 -69.739  -41.641 1.00 130.31 ? 249  MET   A SD  1 
ATOM   1909 C  CE  . MET   A 1 248 ? -29.551 -71.321  -42.378 1.00 127.21 ? 249  MET   A CE  1 
ATOM   1910 N  N   . HIS   A 1 249 ? -33.456 -67.755  -37.398 1.00 84.66  ? 250  HIS   A N   1 
ATOM   1911 C  CA  . HIS   A 1 249 ? -33.494 -66.947  -36.149 1.00 78.61  ? 250  HIS   A CA  1 
ATOM   1912 C  C   . HIS   A 1 249 ? -34.108 -67.773  -35.011 1.00 82.13  ? 250  HIS   A C   1 
ATOM   1913 O  O   . HIS   A 1 249 ? -33.628 -67.647  -33.874 1.00 86.45  ? 250  HIS   A O   1 
ATOM   1914 C  CB  . HIS   A 1 249 ? -34.241 -65.626  -36.368 1.00 74.99  ? 250  HIS   A CB  1 
ATOM   1915 C  CG  . HIS   A 1 249 ? -33.437 -64.597  -37.089 1.00 71.77  ? 250  HIS   A CG  1 
ATOM   1916 N  ND1 . HIS   A 1 249 ? -33.158 -64.693  -38.433 1.00 70.37  ? 250  HIS   A ND1 1 
ATOM   1917 C  CD2 . HIS   A 1 249 ? -32.855 -63.455  -36.662 1.00 71.89  ? 250  HIS   A CD2 1 
ATOM   1918 C  CE1 . HIS   A 1 249 ? -32.439 -63.656  -38.808 1.00 69.73  ? 250  HIS   A CE1 1 
ATOM   1919 N  NE2 . HIS   A 1 249 ? -32.238 -62.879  -37.739 1.00 70.06  ? 250  HIS   A NE2 1 
ATOM   1920 N  N   . GLN   A 1 250 ? -35.116 -68.596  -35.311 1.00 87.63  ? 251  GLN   A N   1 
ATOM   1921 C  CA  . GLN   A 1 250 ? -35.845 -69.419  -34.308 1.00 90.09  ? 251  GLN   A CA  1 
ATOM   1922 C  C   . GLN   A 1 250 ? -34.935 -70.525  -33.755 1.00 90.90  ? 251  GLN   A C   1 
ATOM   1923 O  O   . GLN   A 1 250 ? -35.150 -70.915  -32.591 1.00 95.44  ? 251  GLN   A O   1 
ATOM   1924 C  CB  . GLN   A 1 250 ? -37.125 -69.999  -34.912 1.00 94.52  ? 251  GLN   A CB  1 
ATOM   1925 C  CG  . GLN   A 1 250 ? -38.248 -68.981  -35.051 1.00 97.22  ? 251  GLN   A CG  1 
ATOM   1926 C  CD  . GLN   A 1 250 ? -39.457 -69.568  -35.739 1.00 97.39  ? 251  GLN   A CD  1 
ATOM   1927 O  OE1 . GLN   A 1 250 ? -40.202 -70.353  -35.158 1.00 95.13  ? 251  GLN   A OE1 1 
ATOM   1928 N  NE2 . GLN   A 1 250 ? -39.659 -69.193  -36.992 1.00 97.04  ? 251  GLN   A NE2 1 
ATOM   1929 N  N   . ARG   A 1 251 ? -33.970 -71.017  -34.543 1.00 91.99  ? 252  ARG   A N   1 
ATOM   1930 C  CA  . ARG   A 1 251 ? -32.962 -72.017  -34.084 1.00 93.10  ? 252  ARG   A CA  1 
ATOM   1931 C  C   . ARG   A 1 251 ? -32.041 -71.362  -33.050 1.00 85.80  ? 252  ARG   A C   1 
ATOM   1932 O  O   . ARG   A 1 251 ? -31.906 -71.918  -31.944 1.00 85.36  ? 252  ARG   A O   1 
ATOM   1933 C  CB  . ARG   A 1 251 ? -32.135 -72.577  -35.247 1.00 100.06 ? 252  ARG   A CB  1 
ATOM   1934 C  CG  . ARG   A 1 251 ? -32.827 -73.695  -36.013 1.00 106.56 ? 252  ARG   A CG  1 
ATOM   1935 C  CD  . ARG   A 1 251 ? -32.006 -74.235  -37.169 1.00 111.04 ? 252  ARG   A CD  1 
ATOM   1936 N  NE  . ARG   A 1 251 ? -32.861 -74.942  -38.117 1.00 114.67 ? 252  ARG   A NE  1 
ATOM   1937 C  CZ  . ARG   A 1 251 ? -33.518 -74.380  -39.133 1.00 117.83 ? 252  ARG   A CZ  1 
ATOM   1938 N  NH1 . ARG   A 1 251 ? -33.418 -73.082  -39.370 1.00 115.26 ? 252  ARG   A NH1 1 
ATOM   1939 N  NH2 . ARG   A 1 251 ? -34.275 -75.128  -39.918 1.00 119.32 ? 252  ARG   A NH2 1 
ATOM   1940 N  N   . LEU   A 1 252 ? -31.440 -70.223  -33.401 1.00 81.14  ? 253  LEU   A N   1 
ATOM   1941 C  CA  . LEU   A 1 252 ? -30.511 -69.470  -32.518 1.00 81.07  ? 253  LEU   A CA  1 
ATOM   1942 C  C   . LEU   A 1 252 ? -31.196 -69.219  -31.170 1.00 80.73  ? 253  LEU   A C   1 
ATOM   1943 O  O   . LEU   A 1 252 ? -30.536 -69.424  -30.133 1.00 82.06  ? 253  LEU   A O   1 
ATOM   1944 C  CB  . LEU   A 1 252 ? -30.106 -68.156  -33.197 1.00 80.46  ? 253  LEU   A CB  1 
ATOM   1945 C  CG  . LEU   A 1 252 ? -29.009 -67.352  -32.498 1.00 78.35  ? 253  LEU   A CG  1 
ATOM   1946 C  CD1 . LEU   A 1 252 ? -27.796 -68.216  -32.193 1.00 78.78  ? 253  LEU   A CD1 1 
ATOM   1947 C  CD2 . LEU   A 1 252 ? -28.600 -66.156  -33.342 1.00 77.64  ? 253  LEU   A CD2 1 
ATOM   1948 N  N   . ILE   A 1 253 ? -32.476 -68.832  -31.196 1.00 79.56  ? 254  ILE   A N   1 
ATOM   1949 C  CA  . ILE   A 1 253 ? -33.297 -68.526  -29.984 1.00 80.35  ? 254  ILE   A CA  1 
ATOM   1950 C  C   . ILE   A 1 253 ? -33.419 -69.802  -29.140 1.00 82.84  ? 254  ILE   A C   1 
ATOM   1951 O  O   . ILE   A 1 253 ? -33.176 -69.717  -27.922 1.00 77.34  ? 254  ILE   A O   1 
ATOM   1952 C  CB  . ILE   A 1 253 ? -34.675 -67.944  -30.370 1.00 77.77  ? 254  ILE   A CB  1 
ATOM   1953 C  CG1 . ILE   A 1 253 ? -34.547 -66.623  -31.137 1.00 76.17  ? 254  ILE   A CG1 1 
ATOM   1954 C  CG2 . ILE   A 1 253 ? -35.566 -67.799  -29.144 1.00 75.60  ? 254  ILE   A CG2 1 
ATOM   1955 C  CD1 . ILE   A 1 253 ? -34.365 -65.405  -30.265 1.00 78.03  ? 254  ILE   A CD1 1 
ATOM   1956 N  N   . PHE   A 1 254 ? -33.765 -70.937  -29.761 1.00 88.29  ? 255  PHE   A N   1 
ATOM   1957 C  CA  . PHE   A 1 254 ? -33.880 -72.262  -29.090 1.00 95.81  ? 255  PHE   A CA  1 
ATOM   1958 C  C   . PHE   A 1 254 ? -32.540 -72.636  -28.442 1.00 96.16  ? 255  PHE   A C   1 
ATOM   1959 O  O   . PHE   A 1 254 ? -32.555 -73.034  -27.256 1.00 97.49  ? 255  PHE   A O   1 
ATOM   1960 C  CB  . PHE   A 1 254 ? -34.326 -73.362  -30.060 1.00 101.70 ? 255  PHE   A CB  1 
ATOM   1961 C  CG  . PHE   A 1 254 ? -35.776 -73.320  -30.474 1.00 106.55 ? 255  PHE   A CG  1 
ATOM   1962 C  CD1 . PHE   A 1 254 ? -36.771 -72.978  -29.569 1.00 110.49 ? 255  PHE   A CD1 1 
ATOM   1963 C  CD2 . PHE   A 1 254 ? -36.152 -73.660  -31.765 1.00 109.53 ? 255  PHE   A CD2 1 
ATOM   1964 C  CE1 . PHE   A 1 254 ? -38.101 -72.950  -29.955 1.00 110.74 ? 255  PHE   A CE1 1 
ATOM   1965 C  CE2 . PHE   A 1 254 ? -37.484 -73.635  -32.149 1.00 110.78 ? 255  PHE   A CE2 1 
ATOM   1966 C  CZ  . PHE   A 1 254 ? -38.456 -73.281  -31.242 1.00 112.75 ? 255  PHE   A CZ  1 
ATOM   1967 N  N   . ARG   A 1 255 ? -31.432 -72.521  -29.187 1.00 92.62  ? 256  ARG   A N   1 
ATOM   1968 C  CA  . ARG   A 1 255 ? -30.055 -72.770  -28.672 1.00 91.62  ? 256  ARG   A CA  1 
ATOM   1969 C  C   . ARG   A 1 255 ? -29.802 -71.865  -27.457 1.00 87.43  ? 256  ARG   A C   1 
ATOM   1970 O  O   . ARG   A 1 255 ? -29.293 -72.375  -26.441 1.00 89.03  ? 256  ARG   A O   1 
ATOM   1971 C  CB  . ARG   A 1 255 ? -28.994 -72.539  -29.757 1.00 94.38  ? 256  ARG   A CB  1 
ATOM   1972 C  CG  . ARG   A 1 255 ? -27.581 -72.922  -29.331 1.00 97.37  ? 256  ARG   A CG  1 
ATOM   1973 C  CD  . ARG   A 1 255 ? -26.488 -72.533  -30.317 1.00 98.27  ? 256  ARG   A CD  1 
ATOM   1974 N  NE  . ARG   A 1 255 ? -26.258 -73.545  -31.344 1.00 99.63  ? 256  ARG   A NE  1 
ATOM   1975 C  CZ  . ARG   A 1 255 ? -25.239 -73.554  -32.206 1.00 98.27  ? 256  ARG   A CZ  1 
ATOM   1976 N  NH1 . ARG   A 1 255 ? -24.322 -72.599  -32.189 1.00 101.29 ? 256  ARG   A NH1 1 
ATOM   1977 N  NH2 . ARG   A 1 255 ? -25.143 -74.528  -33.093 1.00 97.56  ? 256  ARG   A NH2 1 
ATOM   1978 N  N   . LEU   A 1 256 ? -30.160 -70.580  -27.557 1.00 82.92  ? 257  LEU   A N   1 
ATOM   1979 C  CA  . LEU   A 1 256 ? -29.898 -69.552  -26.511 1.00 82.92  ? 257  LEU   A CA  1 
ATOM   1980 C  C   . LEU   A 1 256 ? -30.747 -69.818  -25.261 1.00 81.64  ? 257  LEU   A C   1 
ATOM   1981 O  O   . LEU   A 1 256 ? -30.276 -69.477  -24.163 1.00 82.78  ? 257  LEU   A O   1 
ATOM   1982 C  CB  . LEU   A 1 256 ? -30.179 -68.155  -27.077 1.00 81.49  ? 257  LEU   A CB  1 
ATOM   1983 C  CG  . LEU   A 1 256 ? -29.113 -67.595  -28.019 1.00 79.72  ? 257  LEU   A CG  1 
ATOM   1984 C  CD1 . LEU   A 1 256 ? -29.624 -66.350  -28.726 1.00 77.20  ? 257  LEU   A CD1 1 
ATOM   1985 C  CD2 . LEU   A 1 256 ? -27.820 -67.293  -27.273 1.00 79.01  ? 257  LEU   A CD2 1 
ATOM   1986 N  N   . LEU   A 1 257 ? -31.948 -70.386  -25.411 1.00 86.11  ? 258  LEU   A N   1 
ATOM   1987 C  CA  . LEU   A 1 257 ? -32.847 -70.712  -24.267 1.00 87.61  ? 258  LEU   A CA  1 
ATOM   1988 C  C   . LEU   A 1 257 ? -32.191 -71.789  -23.400 1.00 88.68  ? 258  LEU   A C   1 
ATOM   1989 O  O   . LEU   A 1 257 ? -32.356 -71.720  -22.164 1.00 91.11  ? 258  LEU   A O   1 
ATOM   1990 C  CB  . LEU   A 1 257 ? -34.217 -71.180  -24.773 1.00 86.54  ? 258  LEU   A CB  1 
ATOM   1991 C  CG  . LEU   A 1 257 ? -35.136 -70.090  -25.327 1.00 85.24  ? 258  LEU   A CG  1 
ATOM   1992 C  CD1 . LEU   A 1 257 ? -36.358 -70.706  -25.990 1.00 87.01  ? 258  LEU   A CD1 1 
ATOM   1993 C  CD2 . LEU   A 1 257 ? -35.560 -69.113  -24.241 1.00 83.61  ? 258  LEU   A CD2 1 
ATOM   1994 N  N   . LYS   A 1 258 ? -31.472 -72.730  -24.027 1.00 89.81  ? 259  LYS   A N   1 
ATOM   1995 C  CA  . LYS   A 1 258 ? -30.726 -73.820  -23.339 1.00 88.53  ? 259  LYS   A CA  1 
ATOM   1996 C  C   . LYS   A 1 258 ? -29.598 -73.214  -22.491 1.00 86.55  ? 259  LYS   A C   1 
ATOM   1997 O  O   . LYS   A 1 258 ? -29.292 -73.796  -21.439 1.00 89.53  ? 259  LYS   A O   1 
ATOM   1998 C  CB  . LYS   A 1 258 ? -30.232 -74.862  -24.349 1.00 87.38  ? 259  LYS   A CB  1 
ATOM   1999 C  CG  . LYS   A 1 258 ? -31.306 -75.849  -24.789 1.00 91.32  ? 259  LYS   A CG  1 
ATOM   2000 C  CD  . LYS   A 1 258 ? -30.840 -76.930  -25.739 1.00 93.22  ? 259  LYS   A CD  1 
ATOM   2001 C  CE  . LYS   A 1 258 ? -31.934 -77.936  -26.035 1.00 95.77  ? 259  LYS   A CE  1 
ATOM   2002 N  NZ  . LYS   A 1 258 ? -31.449 -79.056  -26.875 1.00 97.34  ? 259  LYS   A NZ  1 
ATOM   2003 N  N   . LEU   A 1 259 ? -29.049 -72.064  -22.896 1.00 84.76  ? 260  LEU   A N   1 
ATOM   2004 C  CA  . LEU   A 1 259 ? -28.026 -71.304  -22.123 1.00 83.42  ? 260  LEU   A CA  1 
ATOM   2005 C  C   . LEU   A 1 259 ? -28.696 -70.307  -21.164 1.00 78.87  ? 260  LEU   A C   1 
ATOM   2006 O  O   . LEU   A 1 259 ? -27.976 -69.466  -20.600 1.00 72.12  ? 260  LEU   A O   1 
ATOM   2007 C  CB  . LEU   A 1 259 ? -27.098 -70.596  -23.114 1.00 84.85  ? 260  LEU   A CB  1 
ATOM   2008 C  CG  . LEU   A 1 259 ? -26.148 -71.524  -23.867 1.00 87.87  ? 260  LEU   A CG  1 
ATOM   2009 C  CD1 . LEU   A 1 259 ? -25.675 -70.890  -25.166 1.00 92.95  ? 260  LEU   A CD1 1 
ATOM   2010 C  CD2 . LEU   A 1 259 ? -24.966 -71.910  -22.991 1.00 86.07  ? 260  LEU   A CD2 1 
ATOM   2011 N  N   . GLU   A 1 260 ? -30.015 -70.408  -20.970 1.00 81.17  ? 261  GLU   A N   1 
ATOM   2012 C  CA  . GLU   A 1 260 ? -30.808 -69.579  -20.021 1.00 85.38  ? 261  GLU   A CA  1 
ATOM   2013 C  C   . GLU   A 1 260 ? -30.289 -68.134  -20.017 1.00 81.88  ? 261  GLU   A C   1 
ATOM   2014 O  O   . GLU   A 1 260 ? -30.114 -67.564  -18.918 1.00 82.25  ? 261  GLU   A O   1 
ATOM   2015 C  CB  . GLU   A 1 260 ? -30.756 -70.189  -18.617 1.00 90.60  ? 261  GLU   A CB  1 
ATOM   2016 C  CG  . GLU   A 1 260 ? -31.299 -71.606  -18.547 1.00 95.22  ? 261  GLU   A CG  1 
ATOM   2017 C  CD  . GLU   A 1 260 ? -31.802 -72.009  -17.171 1.00 100.14 ? 261  GLU   A CD  1 
ATOM   2018 O  OE1 . GLU   A 1 260 ? -31.088 -71.747  -16.185 1.00 108.70 ? 261  GLU   A OE1 1 
ATOM   2019 O  OE2 . GLU   A 1 260 ? -32.915 -72.566  -17.084 1.00 102.90 ? 261  GLU   A OE2 1 
ATOM   2020 N  N   . VAL   A 1 261 ? -30.065 -67.556  -21.201 1.00 75.45  ? 262  VAL   A N   1 
ATOM   2021 C  CA  . VAL   A 1 261 ? -29.617 -66.140  -21.347 1.00 73.97  ? 262  VAL   A CA  1 
ATOM   2022 C  C   . VAL   A 1 261 ? -30.843 -65.251  -21.133 1.00 71.87  ? 262  VAL   A C   1 
ATOM   2023 O  O   . VAL   A 1 261 ? -31.969 -65.748  -21.323 1.00 73.97  ? 262  VAL   A O   1 
ATOM   2024 C  CB  . VAL   A 1 261 ? -28.956 -65.858  -22.712 1.00 75.36  ? 262  VAL   A CB  1 
ATOM   2025 C  CG1 . VAL   A 1 261 ? -27.966 -66.940  -23.117 1.00 74.19  ? 262  VAL   A CG1 1 
ATOM   2026 C  CG2 . VAL   A 1 261 ? -29.982 -65.636  -23.812 1.00 79.17  ? 262  VAL   A CG2 1 
ATOM   2027 N  N   . GLN   A 1 262 ? -30.627 -63.990  -20.757 1.00 69.58  ? 263  GLN   A N   1 
ATOM   2028 C  CA  . GLN   A 1 262 ? -31.695 -62.961  -20.669 1.00 71.58  ? 263  GLN   A CA  1 
ATOM   2029 C  C   . GLN   A 1 262 ? -31.800 -62.263  -22.030 1.00 73.74  ? 263  GLN   A C   1 
ATOM   2030 O  O   . GLN   A 1 262 ? -30.754 -61.861  -22.572 1.00 74.16  ? 263  GLN   A O   1 
ATOM   2031 C  CB  . GLN   A 1 262 ? -31.411 -61.981  -19.529 1.00 71.31  ? 263  GLN   A CB  1 
ATOM   2032 C  CG  . GLN   A 1 262 ? -31.580 -62.600  -18.150 1.00 71.01  ? 263  GLN   A CG  1 
ATOM   2033 C  CD  . GLN   A 1 262 ? -31.231 -61.641  -17.040 1.00 72.07  ? 263  GLN   A CD  1 
ATOM   2034 O  OE1 . GLN   A 1 262 ? -32.102 -61.132  -16.339 1.00 70.19  ? 263  GLN   A OE1 1 
ATOM   2035 N  NE2 . GLN   A 1 262 ? -29.943 -61.384  -16.875 1.00 75.97  ? 263  GLN   A NE2 1 
ATOM   2036 N  N   . PHE   A 1 263 ? -33.017 -62.150  -22.568 1.00 72.30  ? 264  PHE   A N   1 
ATOM   2037 C  CA  . PHE   A 1 263 ? -33.299 -61.525  -23.884 1.00 69.65  ? 264  PHE   A CA  1 
ATOM   2038 C  C   . PHE   A 1 263 ? -33.563 -60.034  -23.679 1.00 70.66  ? 264  PHE   A C   1 
ATOM   2039 O  O   . PHE   A 1 263 ? -34.425 -59.677  -22.859 1.00 74.68  ? 264  PHE   A O   1 
ATOM   2040 C  CB  . PHE   A 1 263 ? -34.456 -62.243  -24.578 1.00 69.86  ? 264  PHE   A CB  1 
ATOM   2041 C  CG  . PHE   A 1 263 ? -34.085 -63.628  -25.034 1.00 70.17  ? 264  PHE   A CG  1 
ATOM   2042 C  CD1 . PHE   A 1 263 ? -33.489 -63.829  -26.269 1.00 68.66  ? 264  PHE   A CD1 1 
ATOM   2043 C  CD2 . PHE   A 1 263 ? -34.279 -64.722  -24.205 1.00 69.61  ? 264  PHE   A CD2 1 
ATOM   2044 C  CE1 . PHE   A 1 263 ? -33.128 -65.102  -26.679 1.00 68.28  ? 264  PHE   A CE1 1 
ATOM   2045 C  CE2 . PHE   A 1 263 ? -33.917 -65.994  -24.618 1.00 68.51  ? 264  PHE   A CE2 1 
ATOM   2046 C  CZ  . PHE   A 1 263 ? -33.340 -66.181  -25.852 1.00 68.19  ? 264  PHE   A CZ  1 
ATOM   2047 N  N   . ILE   A 1 264 ? -32.802 -59.199  -24.387 1.00 69.62  ? 265  ILE   A N   1 
ATOM   2048 C  CA  . ILE   A 1 264 ? -32.972 -57.719  -24.422 1.00 68.11  ? 265  ILE   A CA  1 
ATOM   2049 C  C   . ILE   A 1 264 ? -33.581 -57.364  -25.781 1.00 69.26  ? 265  ILE   A C   1 
ATOM   2050 O  O   . ILE   A 1 264 ? -33.127 -57.927  -26.797 1.00 67.77  ? 265  ILE   A O   1 
ATOM   2051 C  CB  . ILE   A 1 264 ? -31.629 -57.004  -24.173 1.00 68.29  ? 265  ILE   A CB  1 
ATOM   2052 C  CG1 . ILE   A 1 264 ? -31.024 -57.384  -22.816 1.00 67.70  ? 265  ILE   A CG1 1 
ATOM   2053 C  CG2 . ILE   A 1 264 ? -31.790 -55.499  -24.319 1.00 68.98  ? 265  ILE   A CG2 1 
ATOM   2054 C  CD1 . ILE   A 1 264 ? -29.570 -56.990  -22.648 1.00 66.27  ? 265  ILE   A CD1 1 
ATOM   2055 N  N   . ILE   A 1 265 ? -34.592 -56.492  -25.789 1.00 70.71  ? 266  ILE   A N   1 
ATOM   2056 C  CA  . ILE   A 1 265 ? -35.253 -55.991  -27.029 1.00 66.41  ? 266  ILE   A CA  1 
ATOM   2057 C  C   . ILE   A 1 265 ? -34.937 -54.500  -27.162 1.00 65.54  ? 266  ILE   A C   1 
ATOM   2058 O  O   . ILE   A 1 265 ? -35.268 -53.732  -26.230 1.00 64.22  ? 266  ILE   A O   1 
ATOM   2059 C  CB  . ILE   A 1 265 ? -36.763 -56.299  -27.022 1.00 65.62  ? 266  ILE   A CB  1 
ATOM   2060 C  CG1 . ILE   A 1 265 ? -37.017 -57.769  -27.362 1.00 66.41  ? 266  ILE   A CG1 1 
ATOM   2061 C  CG2 . ILE   A 1 265 ? -37.515 -55.378  -27.968 1.00 68.44  ? 266  ILE   A CG2 1 
ATOM   2062 C  CD1 . ILE   A 1 265 ? -38.260 -58.338  -26.736 1.00 67.81  ? 266  ILE   A CD1 1 
ATOM   2063 N  N   . THR   A 1 266 ? -34.305 -54.132  -28.280 1.00 64.02  ? 267  THR   A N   1 
ATOM   2064 C  CA  . THR   A 1 266 ? -33.793 -52.770  -28.579 1.00 63.37  ? 267  THR   A CA  1 
ATOM   2065 C  C   . THR   A 1 266 ? -34.485 -52.240  -29.839 1.00 64.90  ? 267  THR   A C   1 
ATOM   2066 O  O   . THR   A 1 266 ? -34.960 -53.068  -30.641 1.00 60.47  ? 267  THR   A O   1 
ATOM   2067 C  CB  . THR   A 1 266 ? -32.262 -52.786  -28.701 1.00 59.89  ? 267  THR   A CB  1 
ATOM   2068 O  OG1 . THR   A 1 266 ? -31.821 -51.431  -28.740 1.00 60.93  ? 267  THR   A OG1 1 
ATOM   2069 C  CG2 . THR   A 1 266 ? -31.749 -53.520  -29.920 1.00 57.74  ? 267  THR   A CG2 1 
ATOM   2070 N  N   . GLY   A 1 267 ? -34.537 -50.911  -29.988 1.00 71.22  ? 268  GLY   A N   1 
ATOM   2071 C  CA  . GLY   A 1 267 ? -35.127 -50.209  -31.146 1.00 76.03  ? 268  GLY   A CA  1 
ATOM   2072 C  C   . GLY   A 1 267 ? -36.557 -49.765  -30.882 1.00 78.98  ? 268  GLY   A C   1 
ATOM   2073 O  O   . GLY   A 1 267 ? -37.147 -50.222  -29.882 1.00 75.76  ? 268  GLY   A O   1 
ATOM   2074 N  N   . THR   A 1 268 ? -37.097 -48.906  -31.753 1.00 84.45  ? 269  THR   A N   1 
ATOM   2075 C  CA  . THR   A 1 268 ? -38.490 -48.383  -31.696 1.00 86.19  ? 269  THR   A CA  1 
ATOM   2076 C  C   . THR   A 1 268 ? -39.461 -49.442  -32.230 1.00 89.92  ? 269  THR   A C   1 
ATOM   2077 O  O   . THR   A 1 268 ? -39.009 -50.357  -32.947 1.00 82.09  ? 269  THR   A O   1 
ATOM   2078 C  CB  . THR   A 1 268 ? -38.633 -47.073  -32.481 1.00 85.07  ? 269  THR   A CB  1 
ATOM   2079 O  OG1 . THR   A 1 268 ? -38.156 -47.294  -33.809 1.00 84.68  ? 269  THR   A OG1 1 
ATOM   2080 C  CG2 . THR   A 1 268 ? -37.875 -45.926  -31.850 1.00 87.66  ? 269  THR   A CG2 1 
ATOM   2081 N  N   . ASN   A 1 269 ? -40.745 -49.307  -31.886 1.00 101.71 ? 270  ASN   A N   1 
ATOM   2082 C  CA  . ASN   A 1 269 ? -41.837 -50.214  -32.327 1.00 112.24 ? 270  ASN   A CA  1 
ATOM   2083 C  C   . ASN   A 1 269 ? -42.120 -49.959  -33.813 1.00 119.89 ? 270  ASN   A C   1 
ATOM   2084 O  O   . ASN   A 1 269 ? -42.730 -48.918  -34.128 1.00 122.20 ? 270  ASN   A O   1 
ATOM   2085 C  CB  . ASN   A 1 269 ? -43.102 -50.031  -31.484 1.00 115.65 ? 270  ASN   A CB  1 
ATOM   2086 C  CG  . ASN   A 1 269 ? -44.068 -51.192  -31.600 1.00 123.33 ? 270  ASN   A CG  1 
ATOM   2087 O  OD1 . ASN   A 1 269 ? -43.940 -52.030  -32.490 1.00 129.47 ? 270  ASN   A OD1 1 
ATOM   2088 N  ND2 . ASN   A 1 269 ? -45.041 -51.250  -30.705 1.00 130.08 ? 270  ASN   A ND2 1 
ATOM   2089 N  N   . HIS   A 1 270 ? -41.685 -50.874  -34.685 1.00 126.86 ? 271  HIS   A N   1 
ATOM   2090 C  CA  . HIS   A 1 270 ? -41.871 -50.795  -36.160 1.00 131.87 ? 271  HIS   A CA  1 
ATOM   2091 C  C   . HIS   A 1 270 ? -43.273 -51.293  -36.539 1.00 140.03 ? 271  HIS   A C   1 
ATOM   2092 O  O   . HIS   A 1 270 ? -43.740 -50.931  -37.638 1.00 140.39 ? 271  HIS   A O   1 
ATOM   2093 C  CB  . HIS   A 1 270 ? -40.744 -51.542  -36.888 1.00 128.16 ? 271  HIS   A CB  1 
ATOM   2094 C  CG  . HIS   A 1 270 ? -39.430 -50.836  -36.830 1.00 126.47 ? 271  HIS   A CG  1 
ATOM   2095 N  ND1 . HIS   A 1 270 ? -39.292 -49.506  -37.181 1.00 125.61 ? 271  HIS   A ND1 1 
ATOM   2096 C  CD2 . HIS   A 1 270 ? -38.200 -51.262  -36.471 1.00 127.21 ? 271  HIS   A CD2 1 
ATOM   2097 C  CE1 . HIS   A 1 270 ? -38.034 -49.143  -37.035 1.00 125.08 ? 271  HIS   A CE1 1 
ATOM   2098 N  NE2 . HIS   A 1 270 ? -37.342 -50.203  -36.602 1.00 126.31 ? 271  HIS   A NE2 1 
ATOM   2099 N  N   . HIS   A 1 271 ? -43.914 -52.077  -35.661 1.00 146.97 ? 272  HIS   A N   1 
ATOM   2100 C  CA  . HIS   A 1 271 ? -45.319 -52.555  -35.789 1.00 149.95 ? 272  HIS   A CA  1 
ATOM   2101 C  C   . HIS   A 1 271 ? -46.250 -51.618  -35.004 1.00 153.50 ? 272  HIS   A C   1 
ATOM   2102 O  O   . HIS   A 1 271 ? -46.554 -51.931  -33.835 1.00 155.15 ? 272  HIS   A O   1 
ATOM   2103 C  CB  . HIS   A 1 271 ? -45.426 -54.018  -35.330 1.00 149.55 ? 272  HIS   A CB  1 
ATOM   2104 C  CG  . HIS   A 1 271 ? -44.600 -54.967  -36.134 1.00 151.63 ? 272  HIS   A CG  1 
ATOM   2105 N  ND1 . HIS   A 1 271 ? -43.288 -55.262  -35.811 1.00 150.53 ? 272  HIS   A ND1 1 
ATOM   2106 C  CD2 . HIS   A 1 271 ? -44.887 -55.690  -37.238 1.00 151.35 ? 272  HIS   A CD2 1 
ATOM   2107 C  CE1 . HIS   A 1 271 ? -42.805 -56.123  -36.682 1.00 146.18 ? 272  HIS   A CE1 1 
ATOM   2108 N  NE2 . HIS   A 1 271 ? -43.766 -56.403  -37.567 1.00 148.17 ? 272  HIS   A NE2 1 
ATOM   2109 N  N   . SER   A 1 272 ? -46.690 -50.525  -35.640 1.00 156.01 ? 273  SER   A N   1 
ATOM   2110 C  CA  . SER   A 1 272 ? -47.418 -49.379  -35.024 1.00 158.08 ? 273  SER   A CA  1 
ATOM   2111 C  C   . SER   A 1 272 ? -48.740 -49.839  -34.393 1.00 157.97 ? 273  SER   A C   1 
ATOM   2112 O  O   . SER   A 1 272 ? -48.948 -49.563  -33.192 1.00 150.16 ? 273  SER   A O   1 
ATOM   2113 C  CB  . SER   A 1 272 ? -47.657 -48.288  -36.039 1.00 158.95 ? 273  SER   A CB  1 
ATOM   2114 O  OG  . SER   A 1 272 ? -48.214 -47.134  -35.426 1.00 158.34 ? 273  SER   A OG  1 
ATOM   2115 N  N   . GLU   A 1 273 ? -49.596 -50.498  -35.182 1.00 157.99 ? 274  GLU   A N   1 
ATOM   2116 C  CA  . GLU   A 1 273 ? -50.951 -50.966  -34.773 1.00 158.81 ? 274  GLU   A CA  1 
ATOM   2117 C  C   . GLU   A 1 273 ? -50.849 -51.864  -33.531 1.00 162.79 ? 274  GLU   A C   1 
ATOM   2118 O  O   . GLU   A 1 273 ? -51.797 -51.847  -32.722 1.00 164.41 ? 274  GLU   A O   1 
ATOM   2119 C  CB  . GLU   A 1 273 ? -51.647 -51.681  -35.937 1.00 157.16 ? 274  GLU   A CB  1 
ATOM   2120 C  CG  . GLU   A 1 273 ? -50.991 -52.990  -36.355 1.00 155.86 ? 274  GLU   A CG  1 
ATOM   2121 C  CD  . GLU   A 1 273 ? -51.359 -53.487  -37.746 1.00 151.67 ? 274  GLU   A CD  1 
ATOM   2122 O  OE1 . GLU   A 1 273 ? -52.058 -52.754  -38.477 1.00 146.00 ? 274  GLU   A OE1 1 
ATOM   2123 O  OE2 . GLU   A 1 273 ? -50.941 -54.610  -38.100 1.00 144.97 ? 274  GLU   A OE2 1 
ATOM   2124 N  N   . LYS   A 1 274 ? -49.742 -52.604  -33.383 1.00 163.53 ? 275  LYS   A N   1 
ATOM   2125 C  CA  . LYS   A 1 274 ? -49.505 -53.565  -32.270 1.00 160.75 ? 275  LYS   A CA  1 
ATOM   2126 C  C   . LYS   A 1 274 ? -48.816 -52.865  -31.091 1.00 158.66 ? 275  LYS   A C   1 
ATOM   2127 O  O   . LYS   A 1 274 ? -48.123 -51.851  -31.317 1.00 151.18 ? 275  LYS   A O   1 
ATOM   2128 C  CB  . LYS   A 1 274 ? -48.655 -54.742  -32.759 1.00 160.98 ? 275  LYS   A CB  1 
ATOM   2129 C  CG  . LYS   A 1 274 ? -49.312 -55.617  -33.818 1.00 162.30 ? 275  LYS   A CG  1 
ATOM   2130 C  CD  . LYS   A 1 274 ? -50.516 -56.385  -33.309 1.00 162.06 ? 275  LYS   A CD  1 
ATOM   2131 C  CE  . LYS   A 1 274 ? -51.124 -57.302  -34.350 1.00 161.18 ? 275  LYS   A CE  1 
ATOM   2132 N  NZ  . LYS   A 1 274 ? -51.807 -56.542  -35.424 1.00 161.24 ? 275  LYS   A NZ  1 
ATOM   2133 N  N   . GLU   A 1 275 ? -49.008 -53.409  -29.883 1.00 154.38 ? 276  GLU   A N   1 
ATOM   2134 C  CA  . GLU   A 1 275 ? -48.365 -52.959  -28.618 1.00 151.39 ? 276  GLU   A CA  1 
ATOM   2135 C  C   . GLU   A 1 275 ? -46.952 -53.553  -28.558 1.00 148.49 ? 276  GLU   A C   1 
ATOM   2136 O  O   . GLU   A 1 275 ? -46.690 -54.517  -29.302 1.00 145.56 ? 276  GLU   A O   1 
ATOM   2137 C  CB  . GLU   A 1 275 ? -49.236 -53.374  -27.426 1.00 151.80 ? 276  GLU   A CB  1 
ATOM   2138 C  CG  . GLU   A 1 275 ? -48.782 -52.834  -26.076 1.00 150.87 ? 276  GLU   A CG  1 
ATOM   2139 C  CD  . GLU   A 1 275 ? -48.755 -51.322  -25.927 1.00 146.69 ? 276  GLU   A CD  1 
ATOM   2140 O  OE1 . GLU   A 1 275 ? -49.228 -50.623  -26.845 1.00 145.79 ? 276  GLU   A OE1 1 
ATOM   2141 O  OE2 . GLU   A 1 275 ? -48.267 -50.845  -24.882 1.00 142.59 ? 276  GLU   A OE2 1 
ATOM   2142 N  N   . PHE   A 1 276 ? -46.076 -52.988  -27.720 1.00 140.97 ? 277  PHE   A N   1 
ATOM   2143 C  CA  . PHE   A 1 276 ? -44.640 -53.360  -27.617 1.00 132.50 ? 277  PHE   A CA  1 
ATOM   2144 C  C   . PHE   A 1 276 ? -44.486 -54.731  -26.949 1.00 126.12 ? 277  PHE   A C   1 
ATOM   2145 O  O   . PHE   A 1 276 ? -43.512 -55.442  -27.259 1.00 127.45 ? 277  PHE   A O   1 
ATOM   2146 C  CB  . PHE   A 1 276 ? -43.846 -52.294  -26.859 1.00 133.42 ? 277  PHE   A CB  1 
ATOM   2147 C  CG  . PHE   A 1 276 ? -42.449 -52.121  -27.392 1.00 132.87 ? 277  PHE   A CG  1 
ATOM   2148 C  CD1 . PHE   A 1 276 ? -41.473 -53.071  -27.137 1.00 132.62 ? 277  PHE   A CD1 1 
ATOM   2149 C  CD2 . PHE   A 1 276 ? -42.127 -51.038  -28.194 1.00 134.60 ? 277  PHE   A CD2 1 
ATOM   2150 C  CE1 . PHE   A 1 276 ? -40.196 -52.926  -27.653 1.00 132.01 ? 277  PHE   A CE1 1 
ATOM   2151 C  CE2 . PHE   A 1 276 ? -40.849 -50.895  -28.709 1.00 135.43 ? 277  PHE   A CE2 1 
ATOM   2152 C  CZ  . PHE   A 1 276 ? -39.887 -51.841  -28.439 1.00 132.81 ? 277  PHE   A CZ  1 
ATOM   2153 N  N   . CYS   A 1 277 ? -45.416 -55.086  -26.059 1.00 120.68 ? 278  CYS   A N   1 
ATOM   2154 C  CA  . CYS   A 1 277 ? -45.487 -56.405  -25.374 1.00 117.78 ? 278  CYS   A CA  1 
ATOM   2155 C  C   . CYS   A 1 277 ? -45.642 -57.536  -26.403 1.00 115.54 ? 278  CYS   A C   1 
ATOM   2156 O  O   . CYS   A 1 277 ? -45.410 -58.702  -26.029 1.00 111.64 ? 278  CYS   A O   1 
ATOM   2157 C  CB  . CYS   A 1 277 ? -46.638 -56.430  -24.374 1.00 116.97 ? 278  CYS   A CB  1 
ATOM   2158 S  SG  . CYS   A 1 277 ? -48.243 -56.032  -25.113 1.00 110.87 ? 278  CYS   A SG  1 
ATOM   2159 N  N   . SER   A 1 278 ? -46.019 -57.208  -27.646 1.00 112.36 ? 279  SER   A N   1 
ATOM   2160 C  CA  . SER   A 1 278 ? -46.225 -58.168  -28.764 1.00 110.63 ? 279  SER   A CA  1 
ATOM   2161 C  C   . SER   A 1 278 ? -44.940 -58.962  -29.037 1.00 106.31 ? 279  SER   A C   1 
ATOM   2162 O  O   . SER   A 1 278 ? -45.024 -60.208  -29.097 1.00 100.42 ? 279  SER   A O   1 
ATOM   2163 C  CB  . SER   A 1 278 ? -46.707 -57.462  -30.005 1.00 111.39 ? 279  SER   A CB  1 
ATOM   2164 O  OG  . SER   A 1 278 ? -45.783 -56.463  -30.410 1.00 115.40 ? 279  SER   A OG  1 
ATOM   2165 N  N   . TYR   A 1 279 ? -43.806 -58.267  -29.202 1.00 102.36 ? 280  TYR   A N   1 
ATOM   2166 C  CA  . TYR   A 1 279 ? -42.455 -58.862  -29.413 1.00 98.12  ? 280  TYR   A CA  1 
ATOM   2167 C  C   . TYR   A 1 279 ? -42.153 -59.841  -28.277 1.00 98.14  ? 280  TYR   A C   1 
ATOM   2168 O  O   . TYR   A 1 279 ? -41.815 -61.011  -28.540 1.00 101.71 ? 280  TYR   A O   1 
ATOM   2169 C  CB  . TYR   A 1 279 ? -41.358 -57.794  -29.431 1.00 95.32  ? 280  TYR   A CB  1 
ATOM   2170 C  CG  . TYR   A 1 279 ? -41.400 -56.840  -30.597 1.00 94.81  ? 280  TYR   A CG  1 
ATOM   2171 C  CD1 . TYR   A 1 279 ? -40.853 -57.182  -31.823 1.00 92.20  ? 280  TYR   A CD1 1 
ATOM   2172 C  CD2 . TYR   A 1 279 ? -41.970 -55.583  -30.469 1.00 93.05  ? 280  TYR   A CD2 1 
ATOM   2173 C  CE1 . TYR   A 1 279 ? -40.882 -56.305  -32.895 1.00 94.57  ? 280  TYR   A CE1 1 
ATOM   2174 C  CE2 . TYR   A 1 279 ? -42.009 -54.695  -31.531 1.00 92.63  ? 280  TYR   A CE2 1 
ATOM   2175 C  CZ  . TYR   A 1 279 ? -41.463 -55.057  -32.750 1.00 94.26  ? 280  TYR   A CZ  1 
ATOM   2176 O  OH  . TYR   A 1 279 ? -41.495 -54.186  -33.801 1.00 97.34  ? 280  TYR   A OH  1 
ATOM   2177 N  N   . LEU   A 1 280 ? -42.281 -59.349  -27.043 1.00 97.96  ? 281  LEU   A N   1 
ATOM   2178 C  CA  . LEU   A 1 280 ? -42.016 -60.098  -25.788 1.00 99.97  ? 281  LEU   A CA  1 
ATOM   2179 C  C   . LEU   A 1 280 ? -42.832 -61.399  -25.785 1.00 101.73 ? 281  LEU   A C   1 
ATOM   2180 O  O   . LEU   A 1 280 ? -42.240 -62.467  -25.532 1.00 102.78 ? 281  LEU   A O   1 
ATOM   2181 C  CB  . LEU   A 1 280 ? -42.375 -59.185  -24.610 1.00 99.90  ? 281  LEU   A CB  1 
ATOM   2182 C  CG  . LEU   A 1 280 ? -41.992 -59.675  -23.215 1.00 101.45 ? 281  LEU   A CG  1 
ATOM   2183 C  CD1 . LEU   A 1 280 ? -40.661 -60.410  -23.220 1.00 102.43 ? 281  LEU   A CD1 1 
ATOM   2184 C  CD2 . LEU   A 1 280 ? -41.949 -58.511  -22.235 1.00 101.58 ? 281  LEU   A CD2 1 
ATOM   2185 N  N   . GLN   A 1 281 ? -44.128 -61.315  -26.101 1.00 104.18 ? 282  GLN   A N   1 
ATOM   2186 C  CA  . GLN   A 1 281 ? -45.077 -62.464  -26.073 1.00 104.65 ? 282  GLN   A CA  1 
ATOM   2187 C  C   . GLN   A 1 281 ? -44.655 -63.529  -27.095 1.00 97.76  ? 282  GLN   A C   1 
ATOM   2188 O  O   . GLN   A 1 281 ? -44.974 -64.711  -26.862 1.00 90.67  ? 282  GLN   A O   1 
ATOM   2189 C  CB  . GLN   A 1 281 ? -46.511 -61.988  -26.322 1.00 111.36 ? 282  GLN   A CB  1 
ATOM   2190 C  CG  . GLN   A 1 281 ? -47.158 -61.357  -25.096 1.00 114.48 ? 282  GLN   A CG  1 
ATOM   2191 C  CD  . GLN   A 1 281 ? -48.471 -60.685  -25.416 1.00 117.04 ? 282  GLN   A CD  1 
ATOM   2192 O  OE1 . GLN   A 1 281 ? -48.609 -59.468  -25.306 1.00 114.45 ? 282  GLN   A OE1 1 
ATOM   2193 N  NE2 . GLN   A 1 281 ? -49.450 -61.478  -25.826 1.00 118.08 ? 282  GLN   A NE2 1 
ATOM   2194 N  N   . TYR   A 1 282 ? -43.965 -63.143  -28.175 1.00 98.50  ? 283  TYR   A N   1 
ATOM   2195 C  CA  . TYR   A 1 282 ? -43.465 -64.091  -29.206 1.00 100.77 ? 283  TYR   A CA  1 
ATOM   2196 C  C   . TYR   A 1 282 ? -42.359 -64.969  -28.606 1.00 103.34 ? 283  TYR   A C   1 
ATOM   2197 O  O   . TYR   A 1 282 ? -42.381 -66.193  -28.851 1.00 105.37 ? 283  TYR   A O   1 
ATOM   2198 C  CB  . TYR   A 1 282 ? -42.975 -63.380  -30.471 1.00 98.15  ? 283  TYR   A CB  1 
ATOM   2199 C  CG  . TYR   A 1 282 ? -42.615 -64.329  -31.587 1.00 100.18 ? 283  TYR   A CG  1 
ATOM   2200 C  CD1 . TYR   A 1 282 ? -43.582 -65.119  -32.192 1.00 100.90 ? 283  TYR   A CD1 1 
ATOM   2201 C  CD2 . TYR   A 1 282 ? -41.307 -64.465  -32.026 1.00 100.94 ? 283  TYR   A CD2 1 
ATOM   2202 C  CE1 . TYR   A 1 282 ? -43.262 -66.009  -33.205 1.00 101.90 ? 283  TYR   A CE1 1 
ATOM   2203 C  CE2 . TYR   A 1 282 ? -40.971 -65.346  -33.041 1.00 100.38 ? 283  TYR   A CE2 1 
ATOM   2204 C  CZ  . TYR   A 1 282 ? -41.951 -66.123  -33.634 1.00 101.10 ? 283  TYR   A CZ  1 
ATOM   2205 O  OH  . TYR   A 1 282 ? -41.629 -66.993  -34.636 1.00 100.24 ? 283  TYR   A OH  1 
ATOM   2206 N  N   . LEU   A 1 283 ? -41.424 -64.375  -27.854 1.00 100.50 ? 284  LEU   A N   1 
ATOM   2207 C  CA  . LEU   A 1 283 ? -40.323 -65.120  -27.185 1.00 99.70  ? 284  LEU   A CA  1 
ATOM   2208 C  C   . LEU   A 1 283 ? -40.925 -66.136  -26.209 1.00 100.45 ? 284  LEU   A C   1 
ATOM   2209 O  O   . LEU   A 1 283 ? -40.483 -67.305  -26.230 1.00 92.24  ? 284  LEU   A O   1 
ATOM   2210 C  CB  . LEU   A 1 283 ? -39.391 -64.148  -26.453 1.00 98.70  ? 284  LEU   A CB  1 
ATOM   2211 C  CG  . LEU   A 1 283 ? -38.502 -63.274  -27.335 1.00 96.64  ? 284  LEU   A CG  1 
ATOM   2212 C  CD1 . LEU   A 1 283 ? -37.479 -62.539  -26.487 1.00 97.24  ? 284  LEU   A CD1 1 
ATOM   2213 C  CD2 . LEU   A 1 283 ? -37.802 -64.092  -28.408 1.00 97.30  ? 284  LEU   A CD2 1 
ATOM   2214 N  N   . GLU   A 1 284 ? -41.892 -65.702  -25.393 1.00 105.50 ? 285  GLU   A N   1 
ATOM   2215 C  CA  . GLU   A 1 284 ? -42.605 -66.568  -24.414 1.00 108.85 ? 285  GLU   A CA  1 
ATOM   2216 C  C   . GLU   A 1 284 ? -43.299 -67.703  -25.175 1.00 106.11 ? 285  GLU   A C   1 
ATOM   2217 O  O   . GLU   A 1 284 ? -43.174 -68.857  -24.733 1.00 101.24 ? 285  GLU   A O   1 
ATOM   2218 C  CB  . GLU   A 1 284 ? -43.589 -65.757  -23.568 1.00 111.11 ? 285  GLU   A CB  1 
ATOM   2219 C  CG  . GLU   A 1 284 ? -42.909 -64.928  -22.493 1.00 116.54 ? 285  GLU   A CG  1 
ATOM   2220 C  CD  . GLU   A 1 284 ? -43.815 -64.467  -21.364 1.00 121.67 ? 285  GLU   A CD  1 
ATOM   2221 O  OE1 . GLU   A 1 284 ? -45.002 -64.182  -21.632 1.00 121.35 ? 285  GLU   A OE1 1 
ATOM   2222 O  OE2 . GLU   A 1 284 ? -43.330 -64.397  -20.215 1.00 125.21 ? 285  GLU   A OE2 1 
ATOM   2223 N  N   . TYR   A 1 285 ? -43.971 -67.387  -26.287 1.00 106.48 ? 286  TYR   A N   1 
ATOM   2224 C  CA  . TYR   A 1 285 ? -44.600 -68.379  -27.203 1.00 107.31 ? 286  TYR   A CA  1 
ATOM   2225 C  C   . TYR   A 1 285 ? -43.521 -69.349  -27.703 1.00 105.51 ? 286  TYR   A C   1 
ATOM   2226 O  O   . TYR   A 1 285 ? -43.722 -70.577  -27.576 1.00 106.45 ? 286  TYR   A O   1 
ATOM   2227 C  CB  . TYR   A 1 285 ? -45.342 -67.687  -28.353 1.00 107.37 ? 286  TYR   A CB  1 
ATOM   2228 C  CG  . TYR   A 1 285 ? -45.508 -68.524  -29.599 1.00 107.58 ? 286  TYR   A CG  1 
ATOM   2229 C  CD1 . TYR   A 1 285 ? -46.340 -69.634  -29.617 1.00 104.34 ? 286  TYR   A CD1 1 
ATOM   2230 C  CD2 . TYR   A 1 285 ? -44.833 -68.205  -30.768 1.00 106.79 ? 286  TYR   A CD2 1 
ATOM   2231 C  CE1 . TYR   A 1 285 ? -46.495 -70.403  -30.760 1.00 102.74 ? 286  TYR   A CE1 1 
ATOM   2232 C  CE2 . TYR   A 1 285 ? -44.975 -68.964  -31.918 1.00 104.88 ? 286  TYR   A CE2 1 
ATOM   2233 C  CZ  . TYR   A 1 285 ? -45.807 -70.069  -31.914 1.00 105.88 ? 286  TYR   A CZ  1 
ATOM   2234 O  OH  . TYR   A 1 285 ? -45.949 -70.820  -33.045 1.00 107.15 ? 286  TYR   A OH  1 
ATOM   2235 N  N   . LEU   A 1 286 ? -42.414 -68.816  -28.238 1.00 101.32 ? 287  LEU   A N   1 
ATOM   2236 C  CA  . LEU   A 1 286 ? -41.248 -69.615  -28.710 1.00 99.82  ? 287  LEU   A CA  1 
ATOM   2237 C  C   . LEU   A 1 286 ? -40.717 -70.471  -27.554 1.00 103.23 ? 287  LEU   A C   1 
ATOM   2238 O  O   . LEU   A 1 286 ? -40.360 -71.638  -27.799 1.00 103.09 ? 287  LEU   A O   1 
ATOM   2239 C  CB  . LEU   A 1 286 ? -40.149 -68.690  -29.248 1.00 94.71  ? 287  LEU   A CB  1 
ATOM   2240 C  CG  . LEU   A 1 286 ? -40.203 -68.363  -30.740 1.00 91.24  ? 287  LEU   A CG  1 
ATOM   2241 C  CD1 . LEU   A 1 286 ? -38.975 -67.569  -31.149 1.00 91.40  ? 287  LEU   A CD1 1 
ATOM   2242 C  CD2 . LEU   A 1 286 ? -40.310 -69.621  -31.589 1.00 91.13  ? 287  LEU   A CD2 1 
ATOM   2243 N  N   . SER   A 1 287 ? -40.671 -69.906  -26.344 1.00 105.85 ? 288  SER   A N   1 
ATOM   2244 C  CA  . SER   A 1 287 ? -40.189 -70.575  -25.108 1.00 107.29 ? 288  SER   A CA  1 
ATOM   2245 C  C   . SER   A 1 287 ? -41.101 -71.756  -24.748 1.00 106.23 ? 288  SER   A C   1 
ATOM   2246 O  O   . SER   A 1 287 ? -40.564 -72.825  -24.407 1.00 105.38 ? 288  SER   A O   1 
ATOM   2247 C  CB  . SER   A 1 287 ? -40.078 -69.588  -23.979 1.00 106.82 ? 288  SER   A CB  1 
ATOM   2248 O  OG  . SER   A 1 287 ? -39.674 -70.225  -22.776 1.00 110.01 ? 288  SER   A OG  1 
ATOM   2249 N  N   . GLN   A 1 288 ? -42.423 -71.575  -24.827 1.00 108.21 ? 289  GLN   A N   1 
ATOM   2250 C  CA  . GLN   A 1 288 ? -43.421 -72.637  -24.518 1.00 112.31 ? 289  GLN   A CA  1 
ATOM   2251 C  C   . GLN   A 1 288 ? -43.176 -73.840  -25.438 1.00 112.14 ? 289  GLN   A C   1 
ATOM   2252 O  O   . GLN   A 1 288 ? -43.212 -74.980  -24.937 1.00 108.24 ? 289  GLN   A O   1 
ATOM   2253 C  CB  . GLN   A 1 288 ? -44.862 -72.146  -24.694 1.00 116.29 ? 289  GLN   A CB  1 
ATOM   2254 C  CG  . GLN   A 1 288 ? -45.246 -70.920  -23.866 1.00 117.80 ? 289  GLN   A CG  1 
ATOM   2255 C  CD  . GLN   A 1 288 ? -45.061 -71.052  -22.372 1.00 119.45 ? 289  GLN   A CD  1 
ATOM   2256 O  OE1 . GLN   A 1 288 ? -44.995 -70.054  -21.655 1.00 119.00 ? 289  GLN   A OE1 1 
ATOM   2257 N  NE2 . GLN   A 1 288 ? -44.986 -72.278  -21.879 1.00 118.74 ? 289  GLN   A NE2 1 
ATOM   2258 N  N   . ASN   A 1 289 ? -42.927 -73.585  -26.728 1.00 114.61 ? 290  ASN   A N   1 
ATOM   2259 C  CA  . ASN   A 1 289 ? -42.820 -74.616  -27.797 1.00 117.55 ? 290  ASN   A CA  1 
ATOM   2260 C  C   . ASN   A 1 289 ? -41.346 -74.862  -28.137 1.00 121.26 ? 290  ASN   A C   1 
ATOM   2261 O  O   . ASN   A 1 289 ? -40.814 -74.138  -28.997 1.00 127.52 ? 290  ASN   A O   1 
ATOM   2262 C  CB  . ASN   A 1 289 ? -43.573 -74.212  -29.069 1.00 116.36 ? 290  ASN   A CB  1 
ATOM   2263 C  CG  . ASN   A 1 289 ? -44.928 -73.583  -28.814 1.00 114.39 ? 290  ASN   A CG  1 
ATOM   2264 O  OD1 . ASN   A 1 289 ? -45.343 -72.699  -29.558 1.00 109.33 ? 290  ASN   A OD1 1 
ATOM   2265 N  ND2 . ASN   A 1 289 ? -45.625 -74.023  -27.778 1.00 115.56 ? 290  ASN   A ND2 1 
ATOM   2266 N  N   . ARG   A 1 290 ? -40.722 -75.864  -27.512 1.00 124.51 ? 291  ARG   A N   1 
ATOM   2267 C  CA  . ARG   A 1 290 ? -39.325 -76.276  -27.817 1.00 127.50 ? 291  ARG   A CA  1 
ATOM   2268 C  C   . ARG   A 1 290 ? -39.233 -77.800  -27.847 1.00 136.57 ? 291  ARG   A C   1 
ATOM   2269 O  O   . ARG   A 1 290 ? -39.985 -78.478  -27.149 1.00 137.80 ? 291  ARG   A O   1 
ATOM   2270 C  CB  . ARG   A 1 290 ? -38.336 -75.665  -26.817 1.00 123.83 ? 291  ARG   A CB  1 
ATOM   2271 C  CG  . ARG   A 1 290 ? -38.928 -75.243  -25.479 1.00 120.79 ? 291  ARG   A CG  1 
ATOM   2272 C  CD  . ARG   A 1 290 ? -37.811 -74.817  -24.542 1.00 118.04 ? 291  ARG   A CD  1 
ATOM   2273 N  NE  . ARG   A 1 290 ? -38.190 -73.811  -23.559 1.00 117.50 ? 291  ARG   A NE  1 
ATOM   2274 C  CZ  . ARG   A 1 290 ? -37.340 -73.202  -22.732 1.00 112.11 ? 291  ARG   A CZ  1 
ATOM   2275 N  NH1 . ARG   A 1 290 ? -36.050 -73.498  -22.756 1.00 108.58 ? 291  ARG   A NH1 1 
ATOM   2276 N  NH2 . ARG   A 1 290 ? -37.784 -72.295  -21.879 1.00 109.12 ? 291  ARG   A NH2 1 
ATOM   2277 N  N   . PRO   A 1 291 ? -38.319 -78.380  -28.663 1.00 146.82 ? 292  PRO   A N   1 
ATOM   2278 C  CA  . PRO   A 1 291 ? -38.121 -79.831  -28.697 1.00 154.35 ? 292  PRO   A CA  1 
ATOM   2279 C  C   . PRO   A 1 291 ? -37.990 -80.413  -27.290 1.00 165.21 ? 292  PRO   A C   1 
ATOM   2280 O  O   . PRO   A 1 291 ? -37.194 -79.920  -26.494 1.00 169.72 ? 292  PRO   A O   1 
ATOM   2281 C  CB  . PRO   A 1 291 ? -36.816 -80.001  -29.491 1.00 149.25 ? 292  PRO   A CB  1 
ATOM   2282 C  CG  . PRO   A 1 291 ? -36.756 -78.778  -30.385 1.00 144.12 ? 292  PRO   A CG  1 
ATOM   2283 C  CD  . PRO   A 1 291 ? -37.429 -77.671  -29.598 1.00 143.92 ? 292  PRO   A CD  1 
ATOM   2284 N  N   . PRO   A 1 292 ? -38.759 -81.471  -26.934 1.00 177.42 ? 293  PRO   A N   1 
ATOM   2285 C  CA  . PRO   A 1 292 ? -38.834 -81.935  -25.547 1.00 183.88 ? 293  PRO   A CA  1 
ATOM   2286 C  C   . PRO   A 1 292 ? -37.478 -82.382  -25.001 1.00 190.81 ? 293  PRO   A C   1 
ATOM   2287 O  O   . PRO   A 1 292 ? -36.720 -83.045  -25.707 1.00 189.06 ? 293  PRO   A O   1 
ATOM   2288 C  CB  . PRO   A 1 292 ? -39.823 -83.111  -25.604 1.00 181.16 ? 293  PRO   A CB  1 
ATOM   2289 C  CG  . PRO   A 1 292 ? -39.788 -83.565  -27.049 1.00 179.02 ? 293  PRO   A CG  1 
ATOM   2290 C  CD  . PRO   A 1 292 ? -39.567 -82.296  -27.845 1.00 177.45 ? 293  PRO   A CD  1 
ATOM   2291 N  N   . PRO   A 1 293 ? -37.121 -82.034  -23.739 1.00 195.46 ? 294  PRO   A N   1 
ATOM   2292 C  CA  . PRO   A 1 293 ? -35.848 -82.453  -23.158 1.00 196.88 ? 294  PRO   A CA  1 
ATOM   2293 C  C   . PRO   A 1 293 ? -35.932 -83.903  -22.656 1.00 201.10 ? 294  PRO   A C   1 
ATOM   2294 O  O   . PRO   A 1 293 ? -36.933 -84.248  -22.051 1.00 199.19 ? 294  PRO   A O   1 
ATOM   2295 C  CB  . PRO   A 1 293 ? -35.606 -81.473  -21.995 1.00 195.82 ? 294  PRO   A CB  1 
ATOM   2296 C  CG  . PRO   A 1 293 ? -36.868 -80.619  -21.886 1.00 193.16 ? 294  PRO   A CG  1 
ATOM   2297 C  CD  . PRO   A 1 293 ? -37.914 -81.240  -22.791 1.00 194.04 ? 294  PRO   A CD  1 
ATOM   2298 N  N   . ASN   A 1 294 ? -34.891 -84.704  -22.912 1.00 204.45 ? 295  ASN   A N   1 
ATOM   2299 C  CA  . ASN   A 1 294 ? -34.822 -86.142  -22.525 1.00 206.63 ? 295  ASN   A CA  1 
ATOM   2300 C  C   . ASN   A 1 294 ? -34.631 -86.240  -21.003 1.00 206.95 ? 295  ASN   A C   1 
ATOM   2301 O  O   . ASN   A 1 294 ? -34.609 -85.183  -20.340 1.00 208.97 ? 295  ASN   A O   1 
ATOM   2302 C  CB  . ASN   A 1 294 ? -33.757 -86.898  -23.332 1.00 207.16 ? 295  ASN   A CB  1 
ATOM   2303 C  CG  . ASN   A 1 294 ? -32.337 -86.443  -23.066 1.00 208.69 ? 295  ASN   A CG  1 
ATOM   2304 O  OD1 . ASN   A 1 294 ? -31.949 -86.230  -21.920 1.00 213.43 ? 295  ASN   A OD1 1 
ATOM   2305 N  ND2 . ASN   A 1 294 ? -31.544 -86.311  -24.118 1.00 209.57 ? 295  ASN   A ND2 1 
ATOM   2306 N  N   . ALA   A 1 295 ? -34.506 -87.463  -20.475 1.00 207.01 ? 296  ALA   A N   1 
ATOM   2307 C  CA  . ALA   A 1 295 ? -34.443 -87.767  -19.023 1.00 204.62 ? 296  ALA   A CA  1 
ATOM   2308 C  C   . ALA   A 1 295 ? -33.162 -87.193  -18.401 1.00 206.78 ? 296  ALA   A C   1 
ATOM   2309 O  O   . ALA   A 1 295 ? -33.243 -86.710  -17.252 1.00 206.94 ? 296  ALA   A O   1 
ATOM   2310 C  CB  . ALA   A 1 295 ? -34.546 -89.257  -18.801 1.00 200.94 ? 296  ALA   A CB  1 
ATOM   2311 N  N   . TYR   A 1 296 ? -32.032 -87.239  -19.123 1.00 205.70 ? 297  TYR   A N   1 
ATOM   2312 C  CA  . TYR   A 1 296 ? -30.700 -86.763  -18.651 1.00 201.09 ? 297  TYR   A CA  1 
ATOM   2313 C  C   . TYR   A 1 296 ? -30.481 -85.292  -19.042 1.00 194.73 ? 297  TYR   A C   1 
ATOM   2314 O  O   . TYR   A 1 296 ? -29.390 -84.760  -18.745 1.00 194.29 ? 297  TYR   A O   1 
ATOM   2315 C  CB  . TYR   A 1 296 ? -29.579 -87.687  -19.146 1.00 200.65 ? 297  TYR   A CB  1 
ATOM   2316 C  CG  . TYR   A 1 296 ? -29.134 -87.511  -20.576 1.00 199.93 ? 297  TYR   A CG  1 
ATOM   2317 C  CD1 . TYR   A 1 296 ? -28.148 -86.598  -20.916 1.00 195.69 ? 297  TYR   A CD1 1 
ATOM   2318 C  CD2 . TYR   A 1 296 ? -29.662 -88.299  -21.587 1.00 198.96 ? 297  TYR   A CD2 1 
ATOM   2319 C  CE1 . TYR   A 1 296 ? -27.725 -86.446  -22.227 1.00 192.78 ? 297  TYR   A CE1 1 
ATOM   2320 C  CE2 . TYR   A 1 296 ? -29.250 -88.161  -22.902 1.00 196.23 ? 297  TYR   A CE2 1 
ATOM   2321 C  CZ  . TYR   A 1 296 ? -28.277 -87.231  -23.224 1.00 193.89 ? 297  TYR   A CZ  1 
ATOM   2322 O  OH  . TYR   A 1 296 ? -27.863 -87.090  -24.516 1.00 190.14 ? 297  TYR   A OH  1 
ATOM   2323 N  N   . GLU   A 1 297 ? -31.478 -84.662  -19.678 1.00 184.99 ? 298  GLU   A N   1 
ATOM   2324 C  CA  . GLU   A 1 297 ? -31.548 -83.192  -19.922 1.00 172.66 ? 298  GLU   A CA  1 
ATOM   2325 C  C   . GLU   A 1 297 ? -32.433 -82.527  -18.856 1.00 166.44 ? 298  GLU   A C   1 
ATOM   2326 O  O   . GLU   A 1 297 ? -32.279 -81.306  -18.648 1.00 159.90 ? 298  GLU   A O   1 
ATOM   2327 C  CB  . GLU   A 1 297 ? -32.095 -82.894  -21.322 1.00 165.58 ? 298  GLU   A CB  1 
ATOM   2328 C  CG  . GLU   A 1 297 ? -31.076 -83.071  -22.438 1.00 159.04 ? 298  GLU   A CG  1 
ATOM   2329 C  CD  . GLU   A 1 297 ? -31.601 -82.791  -23.838 1.00 149.59 ? 298  GLU   A CD  1 
ATOM   2330 O  OE1 . GLU   A 1 297 ? -32.525 -81.961  -23.973 1.00 142.07 ? 298  GLU   A OE1 1 
ATOM   2331 O  OE2 . GLU   A 1 297 ? -31.085 -83.404  -24.793 1.00 137.40 ? 298  GLU   A OE2 1 
ATOM   2332 N  N   . LEU   A 1 298 ? -33.320 -83.295  -18.209 1.00 162.58 ? 299  LEU   A N   1 
ATOM   2333 C  CA  . LEU   A 1 298 ? -34.332 -82.787  -17.240 1.00 164.22 ? 299  LEU   A CA  1 
ATOM   2334 C  C   . LEU   A 1 298 ? -33.785 -82.867  -15.808 1.00 167.30 ? 299  LEU   A C   1 
ATOM   2335 O  O   . LEU   A 1 298 ? -33.893 -81.853  -15.095 1.00 165.97 ? 299  LEU   A O   1 
ATOM   2336 C  CB  . LEU   A 1 298 ? -35.630 -83.591  -17.385 1.00 164.00 ? 299  LEU   A CB  1 
ATOM   2337 C  CG  . LEU   A 1 298 ? -36.511 -83.208  -18.574 1.00 163.49 ? 299  LEU   A CG  1 
ATOM   2338 C  CD1 . LEU   A 1 298 ? -37.490 -84.323  -18.909 1.00 162.43 ? 299  LEU   A CD1 1 
ATOM   2339 C  CD2 . LEU   A 1 298 ? -37.255 -81.907  -18.312 1.00 160.95 ? 299  LEU   A CD2 1 
ATOM   2340 N  N   . PHE   A 1 299 ? -33.241 -84.020  -15.398 1.00 170.09 ? 300  PHE   A N   1 
ATOM   2341 C  CA  . PHE   A 1 299 ? -32.677 -84.244  -14.036 1.00 172.07 ? 300  PHE   A CA  1 
ATOM   2342 C  C   . PHE   A 1 299 ? -31.382 -83.439  -13.870 1.00 170.58 ? 300  PHE   A C   1 
ATOM   2343 O  O   . PHE   A 1 299 ? -31.269 -82.686  -12.882 1.00 169.95 ? 300  PHE   A O   1 
ATOM   2344 C  CB  . PHE   A 1 299 ? -32.401 -85.725  -13.758 1.00 174.88 ? 300  PHE   A CB  1 
ATOM   2345 C  CG  . PHE   A 1 299 ? -31.461 -85.966  -12.601 1.00 178.07 ? 300  PHE   A CG  1 
ATOM   2346 C  CD1 . PHE   A 1 299 ? -31.933 -86.037  -11.298 1.00 178.08 ? 300  PHE   A CD1 1 
ATOM   2347 C  CD2 . PHE   A 1 299 ? -30.095 -86.089  -12.812 1.00 175.96 ? 300  PHE   A CD2 1 
ATOM   2348 C  CE1 . PHE   A 1 299 ? -31.062 -86.244  -10.238 1.00 177.09 ? 300  PHE   A CE1 1 
ATOM   2349 C  CE2 . PHE   A 1 299 ? -29.226 -86.298  -11.751 1.00 175.16 ? 300  PHE   A CE2 1 
ATOM   2350 C  CZ  . PHE   A 1 299 ? -29.711 -86.374  -10.466 1.00 175.88 ? 300  PHE   A CZ  1 
ATOM   2351 N  N   . ALA   A 1 300 ? -30.439 -83.614  -14.805 1.00 164.85 ? 301  ALA   A N   1 
ATOM   2352 C  CA  . ALA   A 1 300 ? -29.095 -82.983  -14.817 1.00 155.21 ? 301  ALA   A CA  1 
ATOM   2353 C  C   . ALA   A 1 300 ? -29.212 -81.463  -14.636 1.00 148.32 ? 301  ALA   A C   1 
ATOM   2354 O  O   . ALA   A 1 300 ? -28.195 -80.835  -14.283 1.00 145.23 ? 301  ALA   A O   1 
ATOM   2355 C  CB  . ALA   A 1 300 ? -28.376 -83.333  -16.097 1.00 154.18 ? 301  ALA   A CB  1 
ATOM   2356 N  N   . LYS   A 1 301 ? -30.400 -80.902  -14.898 1.00 142.14 ? 302  LYS   A N   1 
ATOM   2357 C  CA  . LYS   A 1 301 ? -30.810 -79.518  -14.531 1.00 134.07 ? 302  LYS   A CA  1 
ATOM   2358 C  C   . LYS   A 1 301 ? -30.398 -79.219  -13.082 1.00 125.34 ? 302  LYS   A C   1 
ATOM   2359 O  O   . LYS   A 1 301 ? -30.898 -79.913  -12.172 1.00 120.60 ? 302  LYS   A O   1 
ATOM   2360 C  CB  . LYS   A 1 301 ? -32.327 -79.369  -14.686 1.00 132.05 ? 302  LYS   A CB  1 
ATOM   2361 C  CG  . LYS   A 1 301 ? -32.865 -77.948  -14.591 1.00 131.56 ? 302  LYS   A CG  1 
ATOM   2362 C  CD  . LYS   A 1 301 ? -33.124 -77.309  -15.937 1.00 131.32 ? 302  LYS   A CD  1 
ATOM   2363 C  CE  . LYS   A 1 301 ? -33.936 -76.037  -15.831 1.00 130.52 ? 302  LYS   A CE  1 
ATOM   2364 N  NZ  . LYS   A 1 301 ? -34.435 -75.595  -17.154 1.00 129.90 ? 302  LYS   A NZ  1 
ATOM   2365 N  N   . GLY   A 1 302 ? -29.531 -78.218  -12.885 1.00 115.45 ? 303  GLY   A N   1 
ATOM   2366 C  CA  . GLY   A 1 302 ? -29.020 -77.798  -11.564 1.00 109.47 ? 303  GLY   A CA  1 
ATOM   2367 C  C   . GLY   A 1 302 ? -27.526 -78.044  -11.417 1.00 103.71 ? 303  GLY   A C   1 
ATOM   2368 O  O   . GLY   A 1 302 ? -26.897 -77.346  -10.596 1.00 101.53 ? 303  GLY   A O   1 
ATOM   2369 N  N   . TYR   A 1 303 ? -26.975 -78.995  -12.182 1.00 96.41  ? 304  TYR   A N   1 
ATOM   2370 C  CA  . TYR   A 1 303 ? -25.561 -79.450  -12.110 1.00 93.42  ? 304  TYR   A CA  1 
ATOM   2371 C  C   . TYR   A 1 303 ? -24.765 -78.959  -13.326 1.00 85.15  ? 304  TYR   A C   1 
ATOM   2372 O  O   . TYR   A 1 303 ? -23.606 -79.393  -13.491 1.00 83.32  ? 304  TYR   A O   1 
ATOM   2373 C  CB  . TYR   A 1 303 ? -25.513 -80.978  -12.015 1.00 98.73  ? 304  TYR   A CB  1 
ATOM   2374 C  CG  . TYR   A 1 303 ? -25.953 -81.538  -10.686 1.00 102.81 ? 304  TYR   A CG  1 
ATOM   2375 C  CD1 . TYR   A 1 303 ? -25.103 -81.518  -9.592  1.00 104.13 ? 304  TYR   A CD1 1 
ATOM   2376 C  CD2 . TYR   A 1 303 ? -27.212 -82.094  -10.520 1.00 104.28 ? 304  TYR   A CD2 1 
ATOM   2377 C  CE1 . TYR   A 1 303 ? -25.491 -82.030  -8.365  1.00 105.76 ? 304  TYR   A CE1 1 
ATOM   2378 C  CE2 . TYR   A 1 303 ? -27.615 -82.614  -9.300  1.00 108.12 ? 304  TYR   A CE2 1 
ATOM   2379 C  CZ  . TYR   A 1 303 ? -26.751 -82.581  -8.219  1.00 107.68 ? 304  TYR   A CZ  1 
ATOM   2380 O  OH  . TYR   A 1 303 ? -27.127 -83.088  -7.010  1.00 110.20 ? 304  TYR   A OH  1 
ATOM   2381 N  N   . GLU   A 1 304 ? -25.351 -78.078  -14.143 1.00 80.46  ? 305  GLU   A N   1 
ATOM   2382 C  CA  . GLU   A 1 304 ? -24.773 -77.639  -15.442 1.00 80.28  ? 305  GLU   A CA  1 
ATOM   2383 C  C   . GLU   A 1 304 ? -23.462 -76.898  -15.175 1.00 75.56  ? 305  GLU   A C   1 
ATOM   2384 O  O   . GLU   A 1 304 ? -23.489 -75.908  -14.427 1.00 76.64  ? 305  GLU   A O   1 
ATOM   2385 C  CB  . GLU   A 1 304 ? -25.748 -76.752  -16.222 1.00 86.90  ? 305  GLU   A CB  1 
ATOM   2386 C  CG  . GLU   A 1 304 ? -26.926 -77.510  -16.818 1.00 91.33  ? 305  GLU   A CG  1 
ATOM   2387 C  CD  . GLU   A 1 304 ? -28.288 -77.184  -16.227 1.00 96.71  ? 305  GLU   A CD  1 
ATOM   2388 O  OE1 . GLU   A 1 304 ? -28.350 -76.764  -15.048 1.00 92.32  ? 305  GLU   A OE1 1 
ATOM   2389 O  OE2 . GLU   A 1 304 ? -29.289 -77.346  -16.955 1.00 107.44 ? 305  GLU   A OE2 1 
ATOM   2390 N  N   . ASP   A 1 305 ? -22.359 -77.397  -15.739 1.00 71.74  ? 306  ASP   A N   1 
ATOM   2391 C  CA  . ASP   A 1 305 ? -20.998 -76.801  -15.644 1.00 69.82  ? 306  ASP   A CA  1 
ATOM   2392 C  C   . ASP   A 1 305 ? -20.587 -76.668  -14.172 1.00 64.53  ? 306  ASP   A C   1 
ATOM   2393 O  O   . ASP   A 1 305 ? -19.736 -75.809  -13.870 1.00 63.85  ? 306  ASP   A O   1 
ATOM   2394 C  CB  . ASP   A 1 305 ? -20.936 -75.466  -16.391 1.00 69.64  ? 306  ASP   A CB  1 
ATOM   2395 C  CG  . ASP   A 1 305 ? -21.280 -75.585  -17.865 1.00 69.93  ? 306  ASP   A CG  1 
ATOM   2396 O  OD1 . ASP   A 1 305 ? -21.012 -76.656  -18.443 1.00 67.50  ? 306  ASP   A OD1 1 
ATOM   2397 O  OD2 . ASP   A 1 305 ? -21.828 -74.609  -18.422 1.00 77.05  ? 306  ASP   A OD2 1 
ATOM   2398 N  N   . TYR   A 1 306 ? -21.149 -77.506  -13.298 1.00 62.28  ? 307  TYR   A N   1 
ATOM   2399 C  CA  . TYR   A 1 306 ? -20.801 -77.573  -11.857 1.00 66.74  ? 307  TYR   A CA  1 
ATOM   2400 C  C   . TYR   A 1 306 ? -19.695 -78.619  -11.682 1.00 65.45  ? 307  TYR   A C   1 
ATOM   2401 O  O   . TYR   A 1 306 ? -19.937 -79.802  -11.985 1.00 68.55  ? 307  TYR   A O   1 
ATOM   2402 C  CB  . TYR   A 1 306 ? -22.038 -77.896  -11.017 1.00 70.83  ? 307  TYR   A CB  1 
ATOM   2403 C  CG  . TYR   A 1 306 ? -21.794 -77.867  -9.530  1.00 75.05  ? 307  TYR   A CG  1 
ATOM   2404 C  CD1 . TYR   A 1 306 ? -21.773 -76.670  -8.834  1.00 80.60  ? 307  TYR   A CD1 1 
ATOM   2405 C  CD2 . TYR   A 1 306 ? -21.567 -79.034  -8.817  1.00 79.38  ? 307  TYR   A CD2 1 
ATOM   2406 C  CE1 . TYR   A 1 306 ? -21.542 -76.632  -7.468  1.00 83.96  ? 307  TYR   A CE1 1 
ATOM   2407 C  CE2 . TYR   A 1 306 ? -21.331 -79.015  -7.451  1.00 78.92  ? 307  TYR   A CE2 1 
ATOM   2408 C  CZ  . TYR   A 1 306 ? -21.318 -77.808  -6.774  1.00 81.56  ? 307  TYR   A CZ  1 
ATOM   2409 O  OH  . TYR   A 1 306 ? -21.089 -77.763  -5.431  1.00 84.77  ? 307  TYR   A OH  1 
ATOM   2410 N  N   . LEU   A 1 307 ? -18.511 -78.194  -11.233 1.00 61.17  ? 308  LEU   A N   1 
ATOM   2411 C  CA  . LEU   A 1 307 ? -17.334 -79.089  -11.083 1.00 59.62  ? 308  LEU   A CA  1 
ATOM   2412 C  C   . LEU   A 1 307 ? -17.472 -79.878  -9.780  1.00 59.97  ? 308  LEU   A C   1 
ATOM   2413 O  O   . LEU   A 1 307 ? -17.817 -79.260  -8.755  1.00 62.74  ? 308  LEU   A O   1 
ATOM   2414 C  CB  . LEU   A 1 307 ? -16.044 -78.264  -11.089 1.00 56.29  ? 308  LEU   A CB  1 
ATOM   2415 C  CG  . LEU   A 1 307 ? -15.755 -77.495  -12.374 1.00 55.53  ? 308  LEU   A CG  1 
ATOM   2416 C  CD1 . LEU   A 1 307 ? -14.463 -76.705  -12.240 1.00 55.32  ? 308  LEU   A CD1 1 
ATOM   2417 C  CD2 . LEU   A 1 307 ? -15.688 -78.428  -13.573 1.00 55.02  ? 308  LEU   A CD2 1 
ATOM   2418 N  N   . GLN   A 1 308 ? -17.218 -81.189  -9.837  1.00 59.12  ? 309  GLN   A N   1 
ATOM   2419 C  CA  . GLN   A 1 308 ? -17.168 -82.099  -8.663  1.00 59.35  ? 309  GLN   A CA  1 
ATOM   2420 C  C   . GLN   A 1 308 ? -15.949 -83.020  -8.766  1.00 56.08  ? 309  GLN   A C   1 
ATOM   2421 O  O   . GLN   A 1 308 ? -15.501 -83.310  -9.898  1.00 52.57  ? 309  GLN   A O   1 
ATOM   2422 C  CB  . GLN   A 1 308 ? -18.427 -82.960  -8.585  1.00 64.39  ? 309  GLN   A CB  1 
ATOM   2423 C  CG  . GLN   A 1 308 ? -19.657 -82.208  -8.106  1.00 72.85  ? 309  GLN   A CG  1 
ATOM   2424 C  CD  . GLN   A 1 308 ? -20.838 -83.137  -7.960  1.00 77.16  ? 309  GLN   A CD  1 
ATOM   2425 O  OE1 . GLN   A 1 308 ? -21.321 -83.709  -8.938  1.00 84.85  ? 309  GLN   A OE1 1 
ATOM   2426 N  NE2 . GLN   A 1 308 ? -21.306 -83.302  -6.733  1.00 76.53  ? 309  GLN   A NE2 1 
ATOM   2427 N  N   . SER   A 1 309 ? -15.460 -83.481  -7.616  1.00 52.97  ? 310  SER   A N   1 
ATOM   2428 C  CA  . SER   A 1 309 ? -14.449 -84.558  -7.495  1.00 52.37  ? 310  SER   A CA  1 
ATOM   2429 C  C   . SER   A 1 309 ? -15.071 -85.872  -7.962  1.00 53.25  ? 310  SER   A C   1 
ATOM   2430 O  O   . SER   A 1 309 ? -16.176 -86.225  -7.545  1.00 50.21  ? 310  SER   A O   1 
ATOM   2431 C  CB  . SER   A 1 309 ? -13.949 -84.668  -6.080  1.00 54.39  ? 310  SER   A CB  1 
ATOM   2432 O  OG  . SER   A 1 309 ? -13.675 -83.388  -5.529  1.00 56.83  ? 310  SER   A OG  1 
ATOM   2433 N  N   . PRO   A 1 310 ? -14.404 -86.637  -8.855  1.00 53.72  ? 311  PRO   A N   1 
ATOM   2434 C  CA  . PRO   A 1 310 ? -14.874 -87.981  -9.185  1.00 53.88  ? 311  PRO   A CA  1 
ATOM   2435 C  C   . PRO   A 1 310 ? -14.878 -88.844  -7.915  1.00 54.28  ? 311  PRO   A C   1 
ATOM   2436 O  O   . PRO   A 1 310 ? -13.952 -88.720  -7.132  1.00 55.20  ? 311  PRO   A O   1 
ATOM   2437 C  CB  . PRO   A 1 310 ? -13.872 -88.493  -10.232 1.00 51.91  ? 311  PRO   A CB  1 
ATOM   2438 C  CG  . PRO   A 1 310 ? -13.205 -87.236  -10.767 1.00 51.90  ? 311  PRO   A CG  1 
ATOM   2439 C  CD  . PRO   A 1 310 ? -13.198 -86.261  -9.607  1.00 51.90  ? 311  PRO   A CD  1 
ATOM   2440 N  N   . LEU   A 1 311 ? -15.921 -89.660  -7.729  1.00 51.57  ? 312  LEU   A N   1 
ATOM   2441 C  CA  . LEU   A 1 311 ? -16.024 -90.618  -6.599  1.00 49.97  ? 312  LEU   A CA  1 
ATOM   2442 C  C   . LEU   A 1 311 ? -14.844 -91.589  -6.673  1.00 49.27  ? 312  LEU   A C   1 
ATOM   2443 O  O   . LEU   A 1 311 ? -14.456 -91.975  -7.792  1.00 47.25  ? 312  LEU   A O   1 
ATOM   2444 C  CB  . LEU   A 1 311 ? -17.359 -91.368  -6.662  1.00 51.21  ? 312  LEU   A CB  1 
ATOM   2445 C  CG  . LEU   A 1 311 ? -18.604 -90.539  -6.344  1.00 51.57  ? 312  LEU   A CG  1 
ATOM   2446 C  CD1 . LEU   A 1 311 ? -19.866 -91.347  -6.605  1.00 52.41  ? 312  LEU   A CD1 1 
ATOM   2447 C  CD2 . LEU   A 1 311 ? -18.587 -90.038  -4.906  1.00 50.79  ? 312  LEU   A CD2 1 
ATOM   2448 N  N   . GLN   A 1 312 ? -14.279 -91.919  -5.511  1.00 50.73  ? 313  GLN   A N   1 
ATOM   2449 C  CA  . GLN   A 1 312 ? -13.270 -92.991  -5.322  1.00 51.62  ? 313  GLN   A CA  1 
ATOM   2450 C  C   . GLN   A 1 312 ? -13.829 -93.957  -4.289  1.00 52.64  ? 313  GLN   A C   1 
ATOM   2451 O  O   . GLN   A 1 312 ? -13.493 -93.870  -3.107  1.00 51.71  ? 313  GLN   A O   1 
ATOM   2452 C  CB  . GLN   A 1 312 ? -11.929 -92.418  -4.869  1.00 51.69  ? 313  GLN   A CB  1 
ATOM   2453 C  CG  . GLN   A 1 312 ? -11.186 -91.693  -5.978  1.00 51.96  ? 313  GLN   A CG  1 
ATOM   2454 C  CD  . GLN   A 1 312 ? -9.782  -91.321  -5.572  1.00 53.36  ? 313  GLN   A CD  1 
ATOM   2455 O  OE1 . GLN   A 1 312 ? -9.111  -92.053  -4.847  1.00 56.24  ? 313  GLN   A OE1 1 
ATOM   2456 N  NE2 . GLN   A 1 312 ? -9.318  -90.178  -6.053  1.00 53.76  ? 313  GLN   A NE2 1 
ATOM   2457 N  N   . PRO   A 1 313 ? -14.723 -94.882  -4.705  1.00 52.19  ? 314  PRO   A N   1 
ATOM   2458 C  CA  . PRO   A 1 313 ? -15.388 -95.781  -3.770  1.00 52.08  ? 314  PRO   A CA  1 
ATOM   2459 C  C   . PRO   A 1 313 ? -14.429 -96.844  -3.223  1.00 51.95  ? 314  PRO   A C   1 
ATOM   2460 O  O   . PRO   A 1 313 ? -14.808 -97.498  -2.282  1.00 56.44  ? 314  PRO   A O   1 
ATOM   2461 C  CB  . PRO   A 1 313 ? -16.519 -96.419  -4.593  1.00 53.32  ? 314  PRO   A CB  1 
ATOM   2462 C  CG  . PRO   A 1 313 ? -16.572 -95.607  -5.872  1.00 53.06  ? 314  PRO   A CG  1 
ATOM   2463 C  CD  . PRO   A 1 313 ? -15.155 -95.121  -6.087  1.00 52.57  ? 314  PRO   A CD  1 
ATOM   2464 N  N   . LEU   A 1 314 ? -13.234 -96.995  -3.805  1.00 51.88  ? 315  LEU   A N   1 
ATOM   2465 C  CA  . LEU   A 1 314 ? -12.181 -97.883  -3.242  1.00 55.93  ? 315  LEU   A CA  1 
ATOM   2466 C  C   . LEU   A 1 314 ? -11.553 -97.221  -2.008  1.00 56.83  ? 315  LEU   A C   1 
ATOM   2467 O  O   . LEU   A 1 314 ? -11.546 -97.853  -0.938  1.00 58.84  ? 315  LEU   A O   1 
ATOM   2468 C  CB  . LEU   A 1 314 ? -11.104 -98.192  -4.287  1.00 55.14  ? 315  LEU   A CB  1 
ATOM   2469 C  CG  . LEU   A 1 314 ? -9.963  -99.063  -3.761  1.00 55.10  ? 315  LEU   A CG  1 
ATOM   2470 C  CD1 . LEU   A 1 314 ? -10.498 -100.383 -3.230  1.00 55.19  ? 315  LEU   A CD1 1 
ATOM   2471 C  CD2 . LEU   A 1 314 ? -8.910  -99.311  -4.826  1.00 56.53  ? 315  LEU   A CD2 1 
ATOM   2472 N  N   . MET   A 1 315 ? -11.013 -96.012  -2.169  1.00 59.79  ? 316  MET   A N   1 
ATOM   2473 C  CA  . MET   A 1 315 ? -10.288 -95.263  -1.107  1.00 60.45  ? 316  MET   A CA  1 
ATOM   2474 C  C   . MET   A 1 315 ? -11.290 -94.792  -0.047  1.00 58.97  ? 316  MET   A C   1 
ATOM   2475 O  O   . MET   A 1 315 ? -10.924 -94.824  1.143   1.00 57.90  ? 316  MET   A O   1 
ATOM   2476 C  CB  . MET   A 1 315 ? -9.549  -94.061  -1.706  1.00 63.63  ? 316  MET   A CB  1 
ATOM   2477 C  CG  . MET   A 1 315 ? -8.645  -93.323  -0.737  1.00 67.83  ? 316  MET   A CG  1 
ATOM   2478 S  SD  . MET   A 1 315 ? -7.778  -91.936  -1.544  1.00 75.67  ? 316  MET   A SD  1 
ATOM   2479 C  CE  . MET   A 1 315 ? -9.130  -90.790  -1.811  1.00 77.36  ? 316  MET   A CE  1 
ATOM   2480 N  N   . ASP   A 1 316 ? -12.499 -94.391  -0.467  1.00 56.88  ? 317  ASP   A N   1 
ATOM   2481 C  CA  . ASP   A 1 316 ? -13.560 -93.805  0.399   1.00 57.29  ? 317  ASP   A CA  1 
ATOM   2482 C  C   . ASP   A 1 316 ? -14.763 -94.749  0.483   1.00 57.24  ? 317  ASP   A C   1 
ATOM   2483 O  O   . ASP   A 1 316 ? -15.022 -95.476  -0.490  1.00 60.73  ? 317  ASP   A O   1 
ATOM   2484 C  CB  . ASP   A 1 316 ? -14.069 -92.464  -0.141  1.00 57.94  ? 317  ASP   A CB  1 
ATOM   2485 C  CG  . ASP   A 1 316 ? -12.998 -91.407  -0.334  1.00 56.67  ? 317  ASP   A CG  1 
ATOM   2486 O  OD1 . ASP   A 1 316 ? -12.010 -91.429  0.419   1.00 57.98  ? 317  ASP   A OD1 1 
ATOM   2487 O  OD2 . ASP   A 1 316 ? -13.169 -90.571  -1.236  1.00 58.44  ? 317  ASP   A OD2 1 
ATOM   2488 N  N   . ASN   A 1 317 ? -15.493 -94.705  1.597   1.00 56.35  ? 318  ASN   A N   1 
ATOM   2489 C  CA  . ASN   A 1 317 ? -16.763 -95.454  1.785   1.00 56.32  ? 318  ASN   A CA  1 
ATOM   2490 C  C   . ASN   A 1 317 ? -17.921 -94.531  1.395   1.00 55.85  ? 318  ASN   A C   1 
ATOM   2491 O  O   . ASN   A 1 317 ? -18.113 -93.502  2.072   1.00 54.04  ? 318  ASN   A O   1 
ATOM   2492 C  CB  . ASN   A 1 317 ? -16.888 -95.996  3.211   1.00 56.11  ? 318  ASN   A CB  1 
ATOM   2493 C  CG  . ASN   A 1 317 ? -16.020 -97.214  3.462   1.00 57.74  ? 318  ASN   A CG  1 
ATOM   2494 O  OD1 . ASN   A 1 317 ? -15.765 -98.009  2.560   1.00 60.76  ? 318  ASN   A OD1 1 
ATOM   2495 N  ND2 . ASN   A 1 317 ? -15.564 -97.380  4.691   1.00 61.61  ? 318  ASN   A ND2 1 
ATOM   2496 N  N   . LEU   A 1 318 ? -18.649 -94.869  0.328   1.00 55.65  ? 319  LEU   A N   1 
ATOM   2497 C  CA  . LEU   A 1 318 ? -19.757 -94.021  -0.187  1.00 56.42  ? 319  LEU   A CA  1 
ATOM   2498 C  C   . LEU   A 1 318 ? -20.826 -93.889  0.899   1.00 55.16  ? 319  LEU   A C   1 
ATOM   2499 O  O   . LEU   A 1 318 ? -21.069 -94.879  1.611   1.00 50.65  ? 319  LEU   A O   1 
ATOM   2500 C  CB  . LEU   A 1 318 ? -20.345 -94.628  -1.466  1.00 56.15  ? 319  LEU   A CB  1 
ATOM   2501 C  CG  . LEU   A 1 318 ? -19.422 -94.661  -2.683  1.00 55.56  ? 319  LEU   A CG  1 
ATOM   2502 C  CD1 . LEU   A 1 318 ? -20.218 -94.932  -3.948  1.00 55.32  ? 319  LEU   A CD1 1 
ATOM   2503 C  CD2 . LEU   A 1 318 ? -18.632 -93.368  -2.820  1.00 55.86  ? 319  LEU   A CD2 1 
ATOM   2504 N  N   . GLU   A 1 319 ? -21.425 -92.702  1.010   1.00 57.94  ? 320  GLU   A N   1 
ATOM   2505 C  CA  . GLU   A 1 319 ? -22.547 -92.402  1.938   1.00 64.09  ? 320  GLU   A CA  1 
ATOM   2506 C  C   . GLU   A 1 319 ? -23.812 -93.125  1.457   1.00 63.65  ? 320  GLU   A C   1 
ATOM   2507 O  O   . GLU   A 1 319 ? -23.912 -93.422  0.248   1.00 62.27  ? 320  GLU   A O   1 
ATOM   2508 C  CB  . GLU   A 1 319 ? -22.786 -90.894  2.012   1.00 68.63  ? 320  GLU   A CB  1 
ATOM   2509 C  CG  . GLU   A 1 319 ? -21.611 -90.119  2.583   1.00 74.32  ? 320  GLU   A CG  1 
ATOM   2510 C  CD  . GLU   A 1 319 ? -21.765 -88.608  2.538   1.00 80.41  ? 320  GLU   A CD  1 
ATOM   2511 O  OE1 . GLU   A 1 319 ? -22.118 -88.082  1.460   1.00 84.56  ? 320  GLU   A OE1 1 
ATOM   2512 O  OE2 . GLU   A 1 319 ? -21.541 -87.961  3.583   1.00 89.29  ? 320  GLU   A OE2 1 
ATOM   2513 N  N   . SER   A 1 320 ? -24.740 -93.397  2.375   1.00 65.51  ? 321  SER   A N   1 
ATOM   2514 C  CA  . SER   A 1 320 ? -26.056 -94.026  2.090   1.00 66.38  ? 321  SER   A CA  1 
ATOM   2515 C  C   . SER   A 1 320 ? -26.719 -93.312  0.899   1.00 66.22  ? 321  SER   A C   1 
ATOM   2516 O  O   . SER   A 1 320 ? -27.204 -94.017  -0.014  1.00 64.27  ? 321  SER   A O   1 
ATOM   2517 C  CB  . SER   A 1 320 ? -26.930 -94.033  3.329   1.00 64.65  ? 321  SER   A CB  1 
ATOM   2518 O  OG  . SER   A 1 320 ? -28.283 -94.317  3.016   1.00 65.32  ? 321  SER   A OG  1 
ATOM   2519 N  N   . GLN   A 1 321 ? -26.698 -91.973  0.875   1.00 64.66  ? 322  GLN   A N   1 
ATOM   2520 C  CA  . GLN   A 1 321 ? -27.417 -91.156  -0.146  1.00 67.04  ? 322  GLN   A CA  1 
ATOM   2521 C  C   . GLN   A 1 321 ? -26.678 -91.166  -1.491  1.00 65.58  ? 322  GLN   A C   1 
ATOM   2522 O  O   . GLN   A 1 321 ? -27.329 -90.861  -2.508  1.00 65.27  ? 322  GLN   A O   1 
ATOM   2523 C  CB  . GLN   A 1 321 ? -27.620 -89.721  0.334   1.00 69.51  ? 322  GLN   A CB  1 
ATOM   2524 C  CG  . GLN   A 1 321 ? -28.721 -89.601  1.373   1.00 77.69  ? 322  GLN   A CG  1 
ATOM   2525 C  CD  . GLN   A 1 321 ? -29.073 -88.168  1.682   1.00 85.79  ? 322  GLN   A CD  1 
ATOM   2526 O  OE1 . GLN   A 1 321 ? -28.743 -87.249  0.934   1.00 95.87  ? 322  GLN   A OE1 1 
ATOM   2527 N  NE2 . GLN   A 1 321 ? -29.757 -87.969  2.796   1.00 87.05  ? 322  GLN   A NE2 1 
ATOM   2528 N  N   . THR   A 1 322 ? -25.379 -91.481  -1.510  1.00 61.77  ? 323  THR   A N   1 
ATOM   2529 C  CA  . THR   A 1 322 ? -24.598 -91.632  -2.766  1.00 59.34  ? 323  THR   A CA  1 
ATOM   2530 C  C   . THR   A 1 322 ? -25.025 -92.944  -3.432  1.00 59.01  ? 323  THR   A C   1 
ATOM   2531 O  O   . THR   A 1 322 ? -25.356 -92.919  -4.632  1.00 58.03  ? 323  THR   A O   1 
ATOM   2532 C  CB  . THR   A 1 322 ? -23.087 -91.542  -2.516  1.00 56.72  ? 323  THR   A CB  1 
ATOM   2533 O  OG1 . THR   A 1 322 ? -22.835 -90.297  -1.866  1.00 52.97  ? 323  THR   A OG1 1 
ATOM   2534 C  CG2 . THR   A 1 322 ? -22.272 -91.624  -3.788  1.00 55.82  ? 323  THR   A CG2 1 
ATOM   2535 N  N   . TYR   A 1 323 ? -25.038 -94.042  -2.675  1.00 60.21  ? 324  TYR   A N   1 
ATOM   2536 C  CA  . TYR   A 1 323 ? -25.597 -95.345  -3.118  1.00 60.82  ? 324  TYR   A CA  1 
ATOM   2537 C  C   . TYR   A 1 323 ? -26.979 -95.086  -3.727  1.00 63.81  ? 324  TYR   A C   1 
ATOM   2538 O  O   . TYR   A 1 323 ? -27.203 -95.488  -4.886  1.00 65.88  ? 324  TYR   A O   1 
ATOM   2539 C  CB  . TYR   A 1 323 ? -25.673 -96.347  -1.963  1.00 58.84  ? 324  TYR   A CB  1 
ATOM   2540 C  CG  . TYR   A 1 323 ? -24.370 -97.024  -1.620  1.00 57.88  ? 324  TYR   A CG  1 
ATOM   2541 C  CD1 . TYR   A 1 323 ? -23.845 -98.010  -2.436  1.00 56.45  ? 324  TYR   A CD1 1 
ATOM   2542 C  CD2 . TYR   A 1 323 ? -23.668 -96.695  -0.470  1.00 57.36  ? 324  TYR   A CD2 1 
ATOM   2543 C  CE1 . TYR   A 1 323 ? -22.655 -98.649  -2.126  1.00 56.72  ? 324  TYR   A CE1 1 
ATOM   2544 C  CE2 . TYR   A 1 323 ? -22.476 -97.325  -0.145  1.00 55.59  ? 324  TYR   A CE2 1 
ATOM   2545 C  CZ  . TYR   A 1 323 ? -21.966 -98.303  -0.978  1.00 55.71  ? 324  TYR   A CZ  1 
ATOM   2546 O  OH  . TYR   A 1 323 ? -20.787 -98.920  -0.675  1.00 58.17  ? 324  TYR   A OH  1 
ATOM   2547 N  N   . GLU   A 1 324 ? -27.845 -94.386  -2.983  1.00 65.34  ? 325  GLU   A N   1 
ATOM   2548 C  CA  . GLU   A 1 324 ? -29.261 -94.119  -3.359  1.00 68.31  ? 325  GLU   A CA  1 
ATOM   2549 C  C   . GLU   A 1 324 ? -29.326 -93.517  -4.768  1.00 70.30  ? 325  GLU   A C   1 
ATOM   2550 O  O   . GLU   A 1 324 ? -30.022 -94.095  -5.614  1.00 75.12  ? 325  GLU   A O   1 
ATOM   2551 C  CB  . GLU   A 1 324 ? -29.932 -93.174  -2.363  1.00 68.95  ? 325  GLU   A CB  1 
ATOM   2552 C  CG  . GLU   A 1 324 ? -31.425 -93.027  -2.593  1.00 69.78  ? 325  GLU   A CG  1 
ATOM   2553 C  CD  . GLU   A 1 324 ? -32.121 -92.113  -1.603  1.00 73.29  ? 325  GLU   A CD  1 
ATOM   2554 O  OE1 . GLU   A 1 324 ? -31.690 -90.949  -1.470  1.00 77.42  ? 325  GLU   A OE1 1 
ATOM   2555 O  OE2 . GLU   A 1 324 ? -33.079 -92.576  -0.952  1.00 78.61  ? 325  GLU   A OE2 1 
ATOM   2556 N  N   . VAL   A 1 325 ? -28.633 -92.398  -4.995  1.00 70.42  ? 326  VAL   A N   1 
ATOM   2557 C  CA  . VAL   A 1 325 ? -28.606 -91.663  -6.295  1.00 69.96  ? 326  VAL   A CA  1 
ATOM   2558 C  C   . VAL   A 1 325 ? -28.349 -92.654  -7.438  1.00 70.25  ? 326  VAL   A C   1 
ATOM   2559 O  O   . VAL   A 1 325 ? -29.113 -92.619  -8.425  1.00 73.78  ? 326  VAL   A O   1 
ATOM   2560 C  CB  . VAL   A 1 325 ? -27.553 -90.537  -6.282  1.00 73.47  ? 326  VAL   A CB  1 
ATOM   2561 C  CG1 . VAL   A 1 325 ? -27.169 -90.087  -7.686  1.00 74.44  ? 326  VAL   A CG1 1 
ATOM   2562 C  CG2 . VAL   A 1 325 ? -28.014 -89.347  -5.455  1.00 72.99  ? 326  VAL   A CG2 1 
ATOM   2563 N  N   . PHE   A 1 326 ? -27.317 -93.495  -7.317  1.00 64.61  ? 327  PHE   A N   1 
ATOM   2564 C  CA  . PHE   A 1 326 ? -26.805 -94.344  -8.425  1.00 64.15  ? 327  PHE   A CA  1 
ATOM   2565 C  C   . PHE   A 1 326 ? -27.545 -95.687  -8.476  1.00 64.56  ? 327  PHE   A C   1 
ATOM   2566 O  O   . PHE   A 1 326 ? -27.304 -96.445  -9.437  1.00 63.28  ? 327  PHE   A O   1 
ATOM   2567 C  CB  . PHE   A 1 326 ? -25.287 -94.496  -8.313  1.00 63.60  ? 327  PHE   A CB  1 
ATOM   2568 C  CG  . PHE   A 1 326 ? -24.554 -93.200  -8.543  1.00 64.23  ? 327  PHE   A CG  1 
ATOM   2569 C  CD1 . PHE   A 1 326 ? -24.449 -92.661  -9.817  1.00 64.95  ? 327  PHE   A CD1 1 
ATOM   2570 C  CD2 . PHE   A 1 326 ? -24.011 -92.492  -7.484  1.00 65.18  ? 327  PHE   A CD2 1 
ATOM   2571 C  CE1 . PHE   A 1 326 ? -23.789 -91.459  -10.027 1.00 66.45  ? 327  PHE   A CE1 1 
ATOM   2572 C  CE2 . PHE   A 1 326 ? -23.356 -91.287  -7.694  1.00 65.30  ? 327  PHE   A CE2 1 
ATOM   2573 C  CZ  . PHE   A 1 326 ? -23.246 -90.772  -8.965  1.00 65.53  ? 327  PHE   A CZ  1 
ATOM   2574 N  N   . GLU   A 1 327 ? -28.418 -95.962  -7.500  1.00 66.66  ? 328  GLU   A N   1 
ATOM   2575 C  CA  . GLU   A 1 327 ? -29.342 -97.133  -7.492  1.00 66.26  ? 328  GLU   A CA  1 
ATOM   2576 C  C   . GLU   A 1 327 ? -30.606 -96.785  -8.293  1.00 68.39  ? 328  GLU   A C   1 
ATOM   2577 O  O   . GLU   A 1 327 ? -31.249 -97.718  -8.813  1.00 64.58  ? 328  GLU   A O   1 
ATOM   2578 C  CB  . GLU   A 1 327 ? -29.699 -97.540  -6.059  1.00 65.10  ? 328  GLU   A CB  1 
ATOM   2579 C  CG  . GLU   A 1 327 ? -28.576 -98.251  -5.323  1.00 65.16  ? 328  GLU   A CG  1 
ATOM   2580 C  CD  . GLU   A 1 327 ? -28.805 -98.447  -3.831  1.00 65.04  ? 328  GLU   A CD  1 
ATOM   2581 O  OE1 . GLU   A 1 327 ? -29.896 -98.080  -3.344  1.00 62.18  ? 328  GLU   A OE1 1 
ATOM   2582 O  OE2 . GLU   A 1 327 ? -27.888 -98.961  -3.151  1.00 60.83  ? 328  GLU   A OE2 1 
ATOM   2583 N  N   . LYS   A 1 328 ? -30.940 -95.491  -8.390  1.00 71.79  ? 329  LYS   A N   1 
ATOM   2584 C  CA  . LYS   A 1 328 ? -32.133 -94.967  -9.111  1.00 75.62  ? 329  LYS   A CA  1 
ATOM   2585 C  C   . LYS   A 1 328 ? -31.822 -94.910  -10.610 1.00 73.77  ? 329  LYS   A C   1 
ATOM   2586 O  O   . LYS   A 1 328 ? -31.726 -93.791  -11.159 1.00 73.71  ? 329  LYS   A O   1 
ATOM   2587 C  CB  . LYS   A 1 328 ? -32.524 -93.585  -8.576  1.00 81.44  ? 329  LYS   A CB  1 
ATOM   2588 C  CG  . LYS   A 1 328 ? -32.867 -93.534  -7.091  1.00 92.79  ? 329  LYS   A CG  1 
ATOM   2589 C  CD  . LYS   A 1 328 ? -34.115 -94.311  -6.705  1.00 98.40  ? 329  LYS   A CD  1 
ATOM   2590 C  CE  . LYS   A 1 328 ? -34.376 -94.318  -5.212  1.00 98.69  ? 329  LYS   A CE  1 
ATOM   2591 N  NZ  . LYS   A 1 328 ? -34.701 -92.965  -4.698  1.00 96.83  ? 329  LYS   A NZ  1 
ATOM   2592 N  N   . ASP   A 1 329 ? -31.680 -96.078  -11.241 1.00 72.07  ? 330  ASP   A N   1 
ATOM   2593 C  CA  . ASP   A 1 329 ? -31.241 -96.209  -12.654 1.00 72.10  ? 330  ASP   A CA  1 
ATOM   2594 C  C   . ASP   A 1 329 ? -31.667 -97.574  -13.188 1.00 69.79  ? 330  ASP   A C   1 
ATOM   2595 O  O   . ASP   A 1 329 ? -30.841 -98.471  -13.334 1.00 70.04  ? 330  ASP   A O   1 
ATOM   2596 C  CB  . ASP   A 1 329 ? -29.730 -95.990  -12.756 1.00 73.37  ? 330  ASP   A CB  1 
ATOM   2597 C  CG  . ASP   A 1 329 ? -29.274 -95.405  -14.079 1.00 75.48  ? 330  ASP   A CG  1 
ATOM   2598 O  OD1 . ASP   A 1 329 ? -30.143 -95.059  -14.909 1.00 76.30  ? 330  ASP   A OD1 1 
ATOM   2599 O  OD2 . ASP   A 1 329 ? -28.050 -95.294  -14.260 1.00 78.72  ? 330  ASP   A OD2 1 
ATOM   2600 N  N   . PRO   A 1 330 ? -32.966 -97.769  -13.512 1.00 70.59  ? 331  PRO   A N   1 
ATOM   2601 C  CA  . PRO   A 1 330 ? -33.492 -99.102  -13.822 1.00 72.88  ? 331  PRO   A CA  1 
ATOM   2602 C  C   . PRO   A 1 330 ? -32.772 -99.790  -14.995 1.00 72.98  ? 331  PRO   A C   1 
ATOM   2603 O  O   . PRO   A 1 330 ? -32.647 -101.003 -14.976 1.00 72.23  ? 331  PRO   A O   1 
ATOM   2604 C  CB  . PRO   A 1 330 ? -34.981 -98.865  -14.140 1.00 73.03  ? 331  PRO   A CB  1 
ATOM   2605 C  CG  . PRO   A 1 330 ? -35.107 -97.370  -14.394 1.00 72.09  ? 331  PRO   A CG  1 
ATOM   2606 C  CD  . PRO   A 1 330 ? -33.990 -96.717  -13.605 1.00 70.18  ? 331  PRO   A CD  1 
ATOM   2607 N  N   . ILE   A 1 331 ? -32.283 -98.994  -15.949 1.00 77.00  ? 332  ILE   A N   1 
ATOM   2608 C  CA  . ILE   A 1 331 ? -31.606 -99.440  -17.203 1.00 79.52  ? 332  ILE   A CA  1 
ATOM   2609 C  C   . ILE   A 1 331 ? -30.284 -100.134 -16.854 1.00 78.98  ? 332  ILE   A C   1 
ATOM   2610 O  O   . ILE   A 1 331 ? -29.945 -101.125 -17.533 1.00 76.75  ? 332  ILE   A O   1 
ATOM   2611 C  CB  . ILE   A 1 331 ? -31.399 -98.243  -18.155 1.00 87.22  ? 332  ILE   A CB  1 
ATOM   2612 C  CG1 . ILE   A 1 331 ? -32.734 -97.566  -18.493 1.00 95.03  ? 332  ILE   A CG1 1 
ATOM   2613 C  CG2 . ILE   A 1 331 ? -30.637 -98.660  -19.408 1.00 85.18  ? 332  ILE   A CG2 1 
ATOM   2614 C  CD1 . ILE   A 1 331 ? -33.007 -96.280  -17.729 1.00 95.02  ? 332  ILE   A CD1 1 
ATOM   2615 N  N   . LYS   A 1 332 ? -29.557 -99.628  -15.853 1.00 78.02  ? 333  LYS   A N   1 
ATOM   2616 C  CA  . LYS   A 1 332 ? -28.268 -100.219 -15.402 1.00 78.74  ? 333  LYS   A CA  1 
ATOM   2617 C  C   . LYS   A 1 332 ? -28.519 -101.650 -14.917 1.00 76.06  ? 333  LYS   A C   1 
ATOM   2618 O  O   . LYS   A 1 332 ? -27.779 -102.562 -15.337 1.00 74.38  ? 333  LYS   A O   1 
ATOM   2619 C  CB  . LYS   A 1 332 ? -27.627 -99.383  -14.289 1.00 81.27  ? 333  LYS   A CB  1 
ATOM   2620 C  CG  . LYS   A 1 332 ? -26.315 -99.946  -13.752 1.00 81.85  ? 333  LYS   A CG  1 
ATOM   2621 C  CD  . LYS   A 1 332 ? -25.636 -99.068  -12.729 1.00 83.10  ? 333  LYS   A CD  1 
ATOM   2622 C  CE  . LYS   A 1 332 ? -26.465 -98.857  -11.481 1.00 84.88  ? 333  LYS   A CE  1 
ATOM   2623 N  NZ  . LYS   A 1 332 ? -25.655 -98.281  -10.383 1.00 85.43  ? 333  LYS   A NZ  1 
ATOM   2624 N  N   . TYR   A 1 333 ? -29.533 -101.831 -14.071 1.00 73.14  ? 334  TYR   A N   1 
ATOM   2625 C  CA  . TYR   A 1 333 ? -29.848 -103.119 -13.406 1.00 74.96  ? 334  TYR   A CA  1 
ATOM   2626 C  C   . TYR   A 1 333 ? -30.493 -104.061 -14.430 1.00 73.81  ? 334  TYR   A C   1 
ATOM   2627 O  O   . TYR   A 1 333 ? -30.055 -105.227 -14.514 1.00 68.38  ? 334  TYR   A O   1 
ATOM   2628 C  CB  . TYR   A 1 333 ? -30.667 -102.854 -12.138 1.00 77.68  ? 334  TYR   A CB  1 
ATOM   2629 C  CG  . TYR   A 1 333 ? -29.879 -102.133 -11.072 1.00 79.71  ? 334  TYR   A CG  1 
ATOM   2630 C  CD1 . TYR   A 1 333 ? -28.805 -102.750 -10.448 1.00 78.10  ? 334  TYR   A CD1 1 
ATOM   2631 C  CD2 . TYR   A 1 333 ? -30.168 -100.825 -10.713 1.00 78.91  ? 334  TYR   A CD2 1 
ATOM   2632 C  CE1 . TYR   A 1 333 ? -28.053 -102.100 -9.484  1.00 77.67  ? 334  TYR   A CE1 1 
ATOM   2633 C  CE2 . TYR   A 1 333 ? -29.425 -100.161 -9.748  1.00 78.79  ? 334  TYR   A CE2 1 
ATOM   2634 C  CZ  . TYR   A 1 333 ? -28.362 -100.800 -9.130  1.00 78.86  ? 334  TYR   A CZ  1 
ATOM   2635 O  OH  . TYR   A 1 333 ? -27.613 -100.167 -8.177  1.00 80.20  ? 334  TYR   A OH  1 
ATOM   2636 N  N   . SER   A 1 334 ? -31.454 -103.565 -15.219 1.00 73.97  ? 335  SER   A N   1 
ATOM   2637 C  CA  . SER   A 1 334 ? -32.154 -104.351 -16.272 1.00 72.88  ? 335  SER   A CA  1 
ATOM   2638 C  C   . SER   A 1 334 ? -31.125 -104.913 -17.263 1.00 71.48  ? 335  SER   A C   1 
ATOM   2639 O  O   . SER   A 1 334 ? -31.311 -106.062 -17.708 1.00 76.89  ? 335  SER   A O   1 
ATOM   2640 C  CB  . SER   A 1 334 ? -33.230 -103.546 -16.966 1.00 72.24  ? 335  SER   A CB  1 
ATOM   2641 O  OG  . SER   A 1 334 ? -32.691 -102.765 -18.019 1.00 73.79  ? 335  SER   A OG  1 
ATOM   2642 N  N   . GLN   A 1 335 ? -30.067 -104.150 -17.565 1.00 69.43  ? 336  GLN   A N   1 
ATOM   2643 C  CA  . GLN   A 1 335 ? -28.956 -104.571 -18.466 1.00 70.76  ? 336  GLN   A CA  1 
ATOM   2644 C  C   . GLN   A 1 335 ? -28.067 -105.600 -17.755 1.00 70.16  ? 336  GLN   A C   1 
ATOM   2645 O  O   . GLN   A 1 335 ? -27.625 -106.548 -18.422 1.00 68.52  ? 336  GLN   A O   1 
ATOM   2646 C  CB  . GLN   A 1 335 ? -28.127 -103.370 -18.936 1.00 71.05  ? 336  GLN   A CB  1 
ATOM   2647 C  CG  . GLN   A 1 335 ? -28.780 -102.557 -20.050 1.00 72.27  ? 336  GLN   A CG  1 
ATOM   2648 C  CD  . GLN   A 1 335 ? -28.834 -103.286 -21.373 1.00 71.21  ? 336  GLN   A CD  1 
ATOM   2649 O  OE1 . GLN   A 1 335 ? -27.847 -103.379 -22.100 1.00 71.78  ? 336  GLN   A OE1 1 
ATOM   2650 N  NE2 . GLN   A 1 335 ? -30.003 -103.809 -21.706 1.00 72.69  ? 336  GLN   A NE2 1 
ATOM   2651 N  N   . TYR   A 1 336 ? -27.793 -105.422 -16.460 1.00 71.42  ? 337  TYR   A N   1 
ATOM   2652 C  CA  . TYR   A 1 336 ? -26.987 -106.379 -15.650 1.00 71.04  ? 337  TYR   A CA  1 
ATOM   2653 C  C   . TYR   A 1 336 ? -27.769 -107.696 -15.517 1.00 69.42  ? 337  TYR   A C   1 
ATOM   2654 O  O   . TYR   A 1 336 ? -27.173 -108.774 -15.734 1.00 63.96  ? 337  TYR   A O   1 
ATOM   2655 C  CB  . TYR   A 1 336 ? -26.596 -105.777 -14.293 1.00 68.25  ? 337  TYR   A CB  1 
ATOM   2656 C  CG  . TYR   A 1 336 ? -25.214 -105.166 -14.240 1.00 63.95  ? 337  TYR   A CG  1 
ATOM   2657 C  CD1 . TYR   A 1 336 ? -24.093 -105.957 -14.047 1.00 61.62  ? 337  TYR   A CD1 1 
ATOM   2658 C  CD2 . TYR   A 1 336 ? -25.023 -103.799 -14.376 1.00 61.06  ? 337  TYR   A CD2 1 
ATOM   2659 C  CE1 . TYR   A 1 336 ? -22.822 -105.407 -13.994 1.00 61.75  ? 337  TYR   A CE1 1 
ATOM   2660 C  CE2 . TYR   A 1 336 ? -23.760 -103.233 -14.332 1.00 58.97  ? 337  TYR   A CE2 1 
ATOM   2661 C  CZ  . TYR   A 1 336 ? -22.653 -104.040 -14.140 1.00 60.44  ? 337  TYR   A CZ  1 
ATOM   2662 O  OH  . TYR   A 1 336 ? -21.403 -103.494 -14.089 1.00 58.11  ? 337  TYR   A OH  1 
ATOM   2663 N  N   . GLN   A 1 337 ? -29.063 -107.604 -15.189 1.00 71.43  ? 338  GLN   A N   1 
ATOM   2664 C  CA  . GLN   A 1 337 ? -30.006 -108.756 -15.129 1.00 76.97  ? 338  GLN   A CA  1 
ATOM   2665 C  C   . GLN   A 1 337 ? -29.922 -109.539 -16.445 1.00 76.33  ? 338  GLN   A C   1 
ATOM   2666 O  O   . GLN   A 1 337 ? -29.757 -110.775 -16.395 1.00 71.42  ? 338  GLN   A O   1 
ATOM   2667 C  CB  . GLN   A 1 337 ? -31.439 -108.277 -14.873 1.00 79.86  ? 338  GLN   A CB  1 
ATOM   2668 C  CG  . GLN   A 1 337 ? -32.423 -109.412 -14.619 1.00 84.56  ? 338  GLN   A CG  1 
ATOM   2669 C  CD  . GLN   A 1 337 ? -33.851 -108.939 -14.479 1.00 89.82  ? 338  GLN   A CD  1 
ATOM   2670 O  OE1 . GLN   A 1 337 ? -34.120 -107.831 -14.018 1.00 90.54  ? 338  GLN   A OE1 1 
ATOM   2671 N  NE2 . GLN   A 1 337 ? -34.790 -109.787 -14.869 1.00 91.47  ? 338  GLN   A NE2 1 
ATOM   2672 N  N   . GLN   A 1 338 ? -30.007 -108.832 -17.576 1.00 77.76  ? 339  GLN   A N   1 
ATOM   2673 C  CA  . GLN   A 1 338 ? -30.025 -109.429 -18.938 1.00 79.25  ? 339  GLN   A CA  1 
ATOM   2674 C  C   . GLN   A 1 338 ? -28.671 -110.086 -19.231 1.00 76.52  ? 339  GLN   A C   1 
ATOM   2675 O  O   . GLN   A 1 338 ? -28.669 -111.178 -19.818 1.00 82.04  ? 339  GLN   A O   1 
ATOM   2676 C  CB  . GLN   A 1 338 ? -30.382 -108.361 -19.975 1.00 83.42  ? 339  GLN   A CB  1 
ATOM   2677 C  CG  . GLN   A 1 338 ? -30.603 -108.899 -21.387 1.00 87.45  ? 339  GLN   A CG  1 
ATOM   2678 C  CD  . GLN   A 1 338 ? -31.762 -109.859 -21.546 1.00 89.54  ? 339  GLN   A CD  1 
ATOM   2679 O  OE1 . GLN   A 1 338 ? -31.896 -110.513 -22.578 1.00 89.79  ? 339  GLN   A OE1 1 
ATOM   2680 N  NE2 . GLN   A 1 338 ? -32.617 -109.959 -20.539 1.00 90.14  ? 339  GLN   A NE2 1 
ATOM   2681 N  N   . ALA   A 1 339 ? -27.566 -109.451 -18.832 1.00 77.14  ? 340  ALA   A N   1 
ATOM   2682 C  CA  . ALA   A 1 339 ? -26.185 -109.942 -19.057 1.00 76.91  ? 340  ALA   A CA  1 
ATOM   2683 C  C   . ALA   A 1 339 ? -25.980 -111.277 -18.333 1.00 76.86  ? 340  ALA   A C   1 
ATOM   2684 O  O   . ALA   A 1 339 ? -25.356 -112.179 -18.922 1.00 73.29  ? 340  ALA   A O   1 
ATOM   2685 C  CB  . ALA   A 1 339 ? -25.188 -108.910 -18.593 1.00 79.34  ? 340  ALA   A CB  1 
ATOM   2686 N  N   . ILE   A 1 340 ? -26.484 -111.390 -17.101 1.00 78.24  ? 341  ILE   A N   1 
ATOM   2687 C  CA  . ILE   A 1 340 ? -26.346 -112.609 -16.248 1.00 80.53  ? 341  ILE   A CA  1 
ATOM   2688 C  C   . ILE   A 1 340 ? -27.265 -113.701 -16.816 1.00 79.04  ? 341  ILE   A C   1 
ATOM   2689 O  O   . ILE   A 1 340 ? -26.800 -114.844 -16.979 1.00 72.86  ? 341  ILE   A O   1 
ATOM   2690 C  CB  . ILE   A 1 340 ? -26.640 -112.272 -14.769 1.00 82.38  ? 341  ILE   A CB  1 
ATOM   2691 C  CG1 . ILE   A 1 340 ? -25.653 -111.234 -14.227 1.00 82.07  ? 341  ILE   A CG1 1 
ATOM   2692 C  CG2 . ILE   A 1 340 ? -26.650 -113.529 -13.910 1.00 82.62  ? 341  ILE   A CG2 1 
ATOM   2693 C  CD1 . ILE   A 1 340 ? -26.078 -110.595 -12.926 1.00 82.46  ? 341  ILE   A CD1 1 
ATOM   2694 N  N   . TYR   A 1 341 ? -28.517 -113.344 -17.114 1.00 81.33  ? 342  TYR   A N   1 
ATOM   2695 C  CA  . TYR   A 1 341 ? -29.529 -114.181 -17.812 1.00 84.69  ? 342  TYR   A CA  1 
ATOM   2696 C  C   . TYR   A 1 341 ? -28.862 -114.949 -18.958 1.00 87.25  ? 342  TYR   A C   1 
ATOM   2697 O  O   . TYR   A 1 341 ? -28.847 -116.194 -18.913 1.00 89.23  ? 342  TYR   A O   1 
ATOM   2698 C  CB  . TYR   A 1 341 ? -30.664 -113.278 -18.303 1.00 88.79  ? 342  TYR   A CB  1 
ATOM   2699 C  CG  . TYR   A 1 341 ? -31.722 -113.921 -19.164 1.00 94.08  ? 342  TYR   A CG  1 
ATOM   2700 C  CD1 . TYR   A 1 341 ? -32.516 -114.950 -18.682 1.00 96.10  ? 342  TYR   A CD1 1 
ATOM   2701 C  CD2 . TYR   A 1 341 ? -31.980 -113.455 -20.444 1.00 96.99  ? 342  TYR   A CD2 1 
ATOM   2702 C  CE1 . TYR   A 1 341 ? -33.512 -115.522 -19.457 1.00 95.72  ? 342  TYR   A CE1 1 
ATOM   2703 C  CE2 . TYR   A 1 341 ? -32.974 -114.012 -21.232 1.00 96.85  ? 342  TYR   A CE2 1 
ATOM   2704 C  CZ  . TYR   A 1 341 ? -33.744 -115.050 -20.737 1.00 98.24  ? 342  TYR   A CZ  1 
ATOM   2705 O  OH  . TYR   A 1 341 ? -34.726 -115.606 -21.505 1.00 98.53  ? 342  TYR   A OH  1 
ATOM   2706 N  N   . LYS   A 1 342 ? -28.302 -114.216 -19.929 1.00 87.36  ? 343  LYS   A N   1 
ATOM   2707 C  CA  . LYS   A 1 342 ? -27.711 -114.762 -21.182 1.00 84.40  ? 343  LYS   A CA  1 
ATOM   2708 C  C   . LYS   A 1 342 ? -26.488 -115.630 -20.863 1.00 81.15  ? 343  LYS   A C   1 
ATOM   2709 O  O   . LYS   A 1 342 ? -26.270 -116.620 -21.591 1.00 83.32  ? 343  LYS   A O   1 
ATOM   2710 C  CB  . LYS   A 1 342 ? -27.337 -113.631 -22.147 1.00 86.23  ? 343  LYS   A CB  1 
ATOM   2711 C  CG  . LYS   A 1 342 ? -28.521 -112.897 -22.766 1.00 91.97  ? 343  LYS   A CG  1 
ATOM   2712 C  CD  . LYS   A 1 342 ? -28.137 -111.803 -23.747 1.00 96.93  ? 343  LYS   A CD  1 
ATOM   2713 C  CE  . LYS   A 1 342 ? -28.268 -112.208 -25.202 1.00 99.20  ? 343  LYS   A CE  1 
ATOM   2714 N  NZ  . LYS   A 1 342 ? -27.416 -113.374 -25.531 1.00 102.55 ? 343  LYS   A NZ  1 
ATOM   2715 N  N   . CYS   A 1 343 ? -25.718 -115.278 -19.829 1.00 77.65  ? 344  CYS   A N   1 
ATOM   2716 C  CA  . CYS   A 1 343 ? -24.461 -115.984 -19.452 1.00 75.81  ? 344  CYS   A CA  1 
ATOM   2717 C  C   . CYS   A 1 343 ? -24.787 -117.334 -18.804 1.00 77.39  ? 344  CYS   A C   1 
ATOM   2718 O  O   . CYS   A 1 343 ? -24.056 -118.310 -19.074 1.00 76.35  ? 344  CYS   A O   1 
ATOM   2719 C  CB  . CYS   A 1 343 ? -23.600 -115.160 -18.502 1.00 70.92  ? 344  CYS   A CB  1 
ATOM   2720 S  SG  . CYS   A 1 343 ? -22.046 -115.988 -18.073 1.00 67.54  ? 344  CYS   A SG  1 
ATOM   2721 N  N   . LEU   A 1 344 ? -25.829 -117.382 -17.969 1.00 78.30  ? 345  LEU   A N   1 
ATOM   2722 C  CA  . LEU   A 1 344 ? -26.243 -118.606 -17.232 1.00 80.87  ? 345  LEU   A CA  1 
ATOM   2723 C  C   . LEU   A 1 344 ? -26.668 -119.681 -18.239 1.00 82.34  ? 345  LEU   A C   1 
ATOM   2724 O  O   . LEU   A 1 344 ? -26.204 -120.833 -18.103 1.00 83.75  ? 345  LEU   A O   1 
ATOM   2725 C  CB  . LEU   A 1 344 ? -27.382 -118.266 -16.265 1.00 81.55  ? 345  LEU   A CB  1 
ATOM   2726 C  CG  . LEU   A 1 344 ? -26.970 -117.551 -14.978 1.00 81.58  ? 345  LEU   A CG  1 
ATOM   2727 C  CD1 . LEU   A 1 344 ? -28.193 -117.036 -14.232 1.00 80.59  ? 345  LEU   A CD1 1 
ATOM   2728 C  CD2 . LEU   A 1 344 ? -26.140 -118.462 -14.080 1.00 82.18  ? 345  LEU   A CD2 1 
ATOM   2729 N  N   . LEU   A 1 345 ? -27.494 -119.307 -19.222 1.00 78.97  ? 346  LEU   A N   1 
ATOM   2730 C  CA  . LEU   A 1 345 ? -28.040 -120.233 -20.250 1.00 77.01  ? 346  LEU   A CA  1 
ATOM   2731 C  C   . LEU   A 1 345 ? -26.894 -120.815 -21.086 1.00 78.74  ? 346  LEU   A C   1 
ATOM   2732 O  O   . LEU   A 1 345 ? -26.959 -122.016 -21.404 1.00 89.27  ? 346  LEU   A O   1 
ATOM   2733 C  CB  . LEU   A 1 345 ? -29.053 -119.488 -21.126 1.00 74.04  ? 346  LEU   A CB  1 
ATOM   2734 C  CG  . LEU   A 1 345 ? -30.294 -118.958 -20.404 1.00 75.20  ? 346  LEU   A CG  1 
ATOM   2735 C  CD1 . LEU   A 1 345 ? -31.312 -118.418 -21.395 1.00 76.46  ? 346  LEU   A CD1 1 
ATOM   2736 C  CD2 . LEU   A 1 345 ? -30.933 -120.028 -19.532 1.00 76.00  ? 346  LEU   A CD2 1 
ATOM   2737 N  N   . ASP   A 1 346 ? -25.879 -120.009 -21.408 1.00 80.11  ? 347  ASP   A N   1 
ATOM   2738 C  CA  . ASP   A 1 346 ? -24.714 -120.430 -22.234 1.00 82.98  ? 347  ASP   A CA  1 
ATOM   2739 C  C   . ASP   A 1 346 ? -23.862 -121.448 -21.461 1.00 83.44  ? 347  ASP   A C   1 
ATOM   2740 O  O   . ASP   A 1 346 ? -23.178 -122.249 -22.124 1.00 86.94  ? 347  ASP   A O   1 
ATOM   2741 C  CB  . ASP   A 1 346 ? -23.866 -119.232 -22.674 1.00 86.38  ? 347  ASP   A CB  1 
ATOM   2742 C  CG  . ASP   A 1 346 ? -24.530 -118.328 -23.704 1.00 88.93  ? 347  ASP   A CG  1 
ATOM   2743 O  OD1 . ASP   A 1 346 ? -25.750 -118.467 -23.916 1.00 91.72  ? 347  ASP   A OD1 1 
ATOM   2744 O  OD2 . ASP   A 1 346 ? -23.819 -117.485 -24.286 1.00 91.60  ? 347  ASP   A OD2 1 
ATOM   2745 N  N   . ARG   A 1 347 ? -23.898 -121.419 -20.123 1.00 86.05  ? 348  ARG   A N   1 
ATOM   2746 C  CA  . ARG   A 1 347 ? -23.011 -122.233 -19.243 1.00 87.21  ? 348  ARG   A CA  1 
ATOM   2747 C  C   . ARG   A 1 347 ? -23.739 -123.469 -18.700 1.00 89.80  ? 348  ARG   A C   1 
ATOM   2748 O  O   . ARG   A 1 347 ? -23.044 -124.456 -18.384 1.00 85.25  ? 348  ARG   A O   1 
ATOM   2749 C  CB  . ARG   A 1 347 ? -22.494 -121.393 -18.072 1.00 84.18  ? 348  ARG   A CB  1 
ATOM   2750 C  CG  . ARG   A 1 347 ? -21.454 -120.352 -18.457 1.00 80.51  ? 348  ARG   A CG  1 
ATOM   2751 C  CD  . ARG   A 1 347 ? -20.900 -119.650 -17.234 1.00 75.16  ? 348  ARG   A CD  1 
ATOM   2752 N  NE  . ARG   A 1 347 ? -19.981 -120.479 -16.462 1.00 70.09  ? 348  ARG   A NE  1 
ATOM   2753 C  CZ  . ARG   A 1 347 ? -18.688 -120.649 -16.732 1.00 68.14  ? 348  ARG   A CZ  1 
ATOM   2754 N  NH1 . ARG   A 1 347 ? -17.946 -121.414 -15.950 1.00 66.51  ? 348  ARG   A NH1 1 
ATOM   2755 N  NH2 . ARG   A 1 347 ? -18.131 -120.059 -17.776 1.00 69.22  ? 348  ARG   A NH2 1 
ATOM   2756 N  N   . VAL   A 1 348 ? -25.069 -123.415 -18.564 1.00 96.81  ? 349  VAL   A N   1 
ATOM   2757 C  CA  . VAL   A 1 348 ? -25.895 -124.534 -18.016 1.00 100.30 ? 349  VAL   A CA  1 
ATOM   2758 C  C   . VAL   A 1 348 ? -26.916 -124.956 -19.072 1.00 99.61  ? 349  VAL   A C   1 
ATOM   2759 O  O   . VAL   A 1 348 ? -27.930 -124.284 -19.264 1.00 86.79  ? 349  VAL   A O   1 
ATOM   2760 C  CB  . VAL   A 1 348 ? -26.564 -124.152 -16.681 1.00 103.67 ? 349  VAL   A CB  1 
ATOM   2761 C  CG1 . VAL   A 1 348 ? -27.299 -125.332 -16.064 1.00 104.40 ? 349  VAL   A CG1 1 
ATOM   2762 C  CG2 . VAL   A 1 348 ? -25.557 -123.584 -15.690 1.00 106.50 ? 349  VAL   A CG2 1 
ATOM   2763 N  N   . PRO   A 1 349 ? -26.663 -126.075 -19.793 1.00 103.22 ? 350  PRO   A N   1 
ATOM   2764 C  CA  . PRO   A 1 349 ? -27.640 -126.642 -20.724 1.00 102.87 ? 350  PRO   A CA  1 
ATOM   2765 C  C   . PRO   A 1 349 ? -28.962 -127.021 -20.038 1.00 102.51 ? 350  PRO   A C   1 
ATOM   2766 O  O   . PRO   A 1 349 ? -28.932 -127.392 -18.876 1.00 99.04  ? 350  PRO   A O   1 
ATOM   2767 C  CB  . PRO   A 1 349 ? -26.957 -127.909 -21.265 1.00 103.88 ? 350  PRO   A CB  1 
ATOM   2768 C  CG  . PRO   A 1 349 ? -25.478 -127.681 -21.029 1.00 106.03 ? 350  PRO   A CG  1 
ATOM   2769 C  CD  . PRO   A 1 349 ? -25.405 -126.840 -19.772 1.00 105.80 ? 350  PRO   A CD  1 
ATOM   2770 N  N   . GLU   A 1 350 ? -30.070 -126.937 -20.782 1.00 103.52 ? 351  GLU   A N   1 
ATOM   2771 C  CA  . GLU   A 1 350 ? -31.454 -127.256 -20.327 1.00 108.51 ? 351  GLU   A CA  1 
ATOM   2772 C  C   . GLU   A 1 350 ? -31.494 -128.640 -19.656 1.00 107.17 ? 351  GLU   A C   1 
ATOM   2773 O  O   . GLU   A 1 350 ? -32.303 -128.811 -18.721 1.00 104.37 ? 351  GLU   A O   1 
ATOM   2774 C  CB  . GLU   A 1 350 ? -32.409 -127.169 -21.522 1.00 112.06 ? 351  GLU   A CB  1 
ATOM   2775 C  CG  . GLU   A 1 350 ? -33.851 -127.539 -21.208 1.00 114.37 ? 351  GLU   A CG  1 
ATOM   2776 C  CD  . GLU   A 1 350 ? -34.582 -126.596 -20.268 1.00 116.33 ? 351  GLU   A CD  1 
ATOM   2777 O  OE1 . GLU   A 1 350 ? -34.169 -125.422 -20.161 1.00 117.00 ? 351  GLU   A OE1 1 
ATOM   2778 O  OE2 . GLU   A 1 350 ? -35.569 -127.039 -19.647 1.00 116.56 ? 351  GLU   A OE2 1 
ATOM   2779 N  N   . GLU   A 1 351 ? -30.664 -129.589 -20.105 1.00 106.92 ? 352  GLU   A N   1 
ATOM   2780 C  CA  . GLU   A 1 351 ? -30.621 -130.981 -19.570 1.00 107.14 ? 352  GLU   A CA  1 
ATOM   2781 C  C   . GLU   A 1 351 ? -30.014 -131.000 -18.154 1.00 105.95 ? 352  GLU   A C   1 
ATOM   2782 O  O   . GLU   A 1 351 ? -30.380 -131.911 -17.381 1.00 101.36 ? 352  GLU   A O   1 
ATOM   2783 C  CB  . GLU   A 1 351 ? -29.873 -131.922 -20.524 1.00 109.23 ? 352  GLU   A CB  1 
ATOM   2784 C  CG  . GLU   A 1 351 ? -28.412 -131.562 -20.778 1.00 109.38 ? 352  GLU   A CG  1 
ATOM   2785 C  CD  . GLU   A 1 351 ? -28.071 -131.083 -22.183 1.00 105.83 ? 352  GLU   A CD  1 
ATOM   2786 O  OE1 . GLU   A 1 351 ? -28.968 -130.543 -22.864 1.00 103.12 ? 352  GLU   A OE1 1 
ATOM   2787 O  OE2 . GLU   A 1 351 ? -26.902 -131.246 -22.593 1.00 100.38 ? 352  GLU   A OE2 1 
ATOM   2788 N  N   . GLU   A 1 352 ? -29.142 -130.039 -17.815 1.00 105.36 ? 353  GLU   A N   1 
ATOM   2789 C  CA  . GLU   A 1 352 ? -28.367 -130.018 -16.540 1.00 100.73 ? 353  GLU   A CA  1 
ATOM   2790 C  C   . GLU   A 1 352 ? -28.955 -129.012 -15.539 1.00 100.24 ? 353  GLU   A C   1 
ATOM   2791 O  O   . GLU   A 1 352 ? -28.386 -128.906 -14.436 1.00 98.15  ? 353  GLU   A O   1 
ATOM   2792 C  CB  . GLU   A 1 352 ? -26.904 -129.638 -16.786 1.00 95.31  ? 353  GLU   A CB  1 
ATOM   2793 C  CG  . GLU   A 1 352 ? -26.241 -130.397 -17.918 1.00 94.34  ? 353  GLU   A CG  1 
ATOM   2794 C  CD  . GLU   A 1 352 ? -24.727 -130.264 -17.948 1.00 98.43  ? 353  GLU   A CD  1 
ATOM   2795 O  OE1 . GLU   A 1 352 ? -24.114 -130.241 -16.861 1.00 99.47  ? 353  GLU   A OE1 1 
ATOM   2796 O  OE2 . GLU   A 1 352 ? -24.162 -130.177 -19.057 1.00 98.56  ? 353  GLU   A OE2 1 
ATOM   2797 N  N   . LYS   A 1 353 ? -30.047 -128.320 -15.889 1.00 102.95 ? 354  LYS   A N   1 
ATOM   2798 C  CA  . LYS   A 1 353 ? -30.532 -127.104 -15.172 1.00 106.75 ? 354  LYS   A CA  1 
ATOM   2799 C  C   . LYS   A 1 353 ? -30.712 -127.389 -13.673 1.00 110.83 ? 354  LYS   A C   1 
ATOM   2800 O  O   . LYS   A 1 353 ? -30.381 -126.493 -12.866 1.00 118.46 ? 354  LYS   A O   1 
ATOM   2801 C  CB  . LYS   A 1 353 ? -31.821 -126.561 -15.804 1.00 104.89 ? 354  LYS   A CB  1 
ATOM   2802 C  CG  . LYS   A 1 353 ? -33.075 -127.407 -15.631 1.00 105.67 ? 354  LYS   A CG  1 
ATOM   2803 C  CD  . LYS   A 1 353 ? -34.346 -126.643 -15.939 1.00 106.80 ? 354  LYS   A CD  1 
ATOM   2804 C  CE  . LYS   A 1 353 ? -35.599 -127.455 -15.695 1.00 110.60 ? 354  LYS   A CE  1 
ATOM   2805 N  NZ  . LYS   A 1 353 ? -36.763 -126.584 -15.410 1.00 112.91 ? 354  LYS   A NZ  1 
ATOM   2806 N  N   . ASP   A 1 354 ? -31.195 -128.583 -13.312 1.00 111.16 ? 355  ASP   A N   1 
ATOM   2807 C  CA  . ASP   A 1 354 ? -31.624 -128.921 -11.928 1.00 112.35 ? 355  ASP   A CA  1 
ATOM   2808 C  C   . ASP   A 1 354 ? -30.453 -129.489 -11.115 1.00 110.13 ? 355  ASP   A C   1 
ATOM   2809 O  O   . ASP   A 1 354 ? -30.557 -129.470 -9.876  1.00 108.66 ? 355  ASP   A O   1 
ATOM   2810 C  CB  . ASP   A 1 354 ? -32.818 -129.881 -11.942 1.00 116.09 ? 355  ASP   A CB  1 
ATOM   2811 C  CG  . ASP   A 1 354 ? -34.147 -129.203 -12.239 1.00 119.13 ? 355  ASP   A CG  1 
ATOM   2812 O  OD1 . ASP   A 1 354 ? -34.373 -128.092 -11.711 1.00 116.36 ? 355  ASP   A OD1 1 
ATOM   2813 O  OD2 . ASP   A 1 354 ? -34.946 -129.791 -12.996 1.00 122.04 ? 355  ASP   A OD2 1 
ATOM   2814 N  N   . THR   A 1 355 ? -29.387 -129.966 -11.769 1.00 108.92 ? 356  THR   A N   1 
ATOM   2815 C  CA  . THR   A 1 355 ? -28.207 -130.593 -11.108 1.00 111.33 ? 356  THR   A CA  1 
ATOM   2816 C  C   . THR   A 1 355 ? -27.036 -129.603 -11.002 1.00 108.75 ? 356  THR   A C   1 
ATOM   2817 O  O   . THR   A 1 355 ? -26.200 -129.801 -10.098 1.00 110.29 ? 356  THR   A O   1 
ATOM   2818 C  CB  . THR   A 1 355 ? -27.771 -131.871 -11.838 1.00 112.28 ? 356  THR   A CB  1 
ATOM   2819 O  OG1 . THR   A 1 355 ? -27.604 -131.558 -13.221 1.00 114.63 ? 356  THR   A OG1 1 
ATOM   2820 C  CG2 . THR   A 1 355 ? -28.761 -133.005 -11.684 1.00 113.57 ? 356  THR   A CG2 1 
ATOM   2821 N  N   . ASN   A 1 356 ? -26.970 -128.590 -11.876 1.00 106.95 ? 357  ASN   A N   1 
ATOM   2822 C  CA  . ASN   A 1 356 ? -25.798 -127.679 -12.014 1.00 105.41 ? 357  ASN   A CA  1 
ATOM   2823 C  C   . ASN   A 1 356 ? -26.104 -126.315 -11.381 1.00 103.45 ? 357  ASN   A C   1 
ATOM   2824 O  O   . ASN   A 1 356 ? -26.886 -125.542 -11.977 1.00 104.19 ? 357  ASN   A O   1 
ATOM   2825 C  CB  . ASN   A 1 356 ? -25.376 -127.511 -13.476 1.00 104.77 ? 357  ASN   A CB  1 
ATOM   2826 C  CG  . ASN   A 1 356 ? -24.036 -126.822 -13.630 1.00 102.09 ? 357  ASN   A CG  1 
ATOM   2827 O  OD1 . ASN   A 1 356 ? -23.408 -126.439 -12.645 1.00 102.26 ? 357  ASN   A OD1 1 
ATOM   2828 N  ND2 . ASN   A 1 356 ? -23.585 -126.667 -14.862 1.00 99.25  ? 357  ASN   A ND2 1 
ATOM   2829 N  N   . VAL   A 1 357 ? -25.484 -126.038 -10.228 1.00 100.08 ? 358  VAL   A N   1 
ATOM   2830 C  CA  . VAL   A 1 357 ? -25.580 -124.745 -9.486  1.00 98.03  ? 358  VAL   A CA  1 
ATOM   2831 C  C   . VAL   A 1 357 ? -24.352 -123.900 -9.844  1.00 90.44  ? 358  VAL   A C   1 
ATOM   2832 O  O   . VAL   A 1 357 ? -23.220 -124.400 -9.656  1.00 83.90  ? 358  VAL   A O   1 
ATOM   2833 C  CB  . VAL   A 1 357 ? -25.687 -124.972 -7.964  1.00 102.03 ? 358  VAL   A CB  1 
ATOM   2834 C  CG1 . VAL   A 1 357 ? -25.688 -123.662 -7.189  1.00 102.66 ? 358  VAL   A CG1 1 
ATOM   2835 C  CG2 . VAL   A 1 357 ? -26.911 -125.804 -7.602  1.00 102.96 ? 358  VAL   A CG2 1 
ATOM   2836 N  N   . GLN   A 1 358 ? -24.573 -122.678 -10.341 1.00 84.72  ? 359  GLN   A N   1 
ATOM   2837 C  CA  . GLN   A 1 358 ? -23.502 -121.723 -10.739 1.00 82.59  ? 359  GLN   A CA  1 
ATOM   2838 C  C   . GLN   A 1 358 ? -23.098 -120.874 -9.527  1.00 80.41  ? 359  GLN   A C   1 
ATOM   2839 O  O   . GLN   A 1 358 ? -23.996 -120.294 -8.877  1.00 74.09  ? 359  GLN   A O   1 
ATOM   2840 C  CB  . GLN   A 1 358 ? -23.967 -120.824 -11.888 1.00 82.62  ? 359  GLN   A CB  1 
ATOM   2841 C  CG  . GLN   A 1 358 ? -24.059 -121.538 -13.229 1.00 83.04  ? 359  GLN   A CG  1 
ATOM   2842 C  CD  . GLN   A 1 358 ? -22.700 -121.875 -13.794 1.00 80.62  ? 359  GLN   A CD  1 
ATOM   2843 O  OE1 . GLN   A 1 358 ? -22.066 -121.063 -14.463 1.00 83.13  ? 359  GLN   A OE1 1 
ATOM   2844 N  NE2 . GLN   A 1 358 ? -22.242 -123.088 -13.536 1.00 80.42  ? 359  GLN   A NE2 1 
ATOM   2845 N  N   . VAL   A 1 359 ? -21.794 -120.812 -9.242  1.00 76.15  ? 360  VAL   A N   1 
ATOM   2846 C  CA  . VAL   A 1 359 ? -21.189 -119.900 -8.227  1.00 77.65  ? 360  VAL   A CA  1 
ATOM   2847 C  C   . VAL   A 1 359 ? -21.088 -118.505 -8.858  1.00 74.84  ? 360  VAL   A C   1 
ATOM   2848 O  O   . VAL   A 1 359 ? -20.111 -118.260 -9.598  1.00 72.42  ? 360  VAL   A O   1 
ATOM   2849 C  CB  . VAL   A 1 359 ? -19.815 -120.415 -7.746  1.00 81.60  ? 360  VAL   A CB  1 
ATOM   2850 C  CG1 . VAL   A 1 359 ? -19.170 -119.478 -6.734  1.00 78.37  ? 360  VAL   A CG1 1 
ATOM   2851 C  CG2 . VAL   A 1 359 ? -19.905 -121.823 -7.175  1.00 82.41  ? 360  VAL   A CG2 1 
ATOM   2852 N  N   . LEU   A 1 360 ? -22.079 -117.646 -8.591  1.00 74.56  ? 361  LEU   A N   1 
ATOM   2853 C  CA  . LEU   A 1 360 ? -22.099 -116.208 -8.975  1.00 76.55  ? 361  LEU   A CA  1 
ATOM   2854 C  C   . LEU   A 1 360 ? -21.630 -115.374 -7.774  1.00 75.35  ? 361  LEU   A C   1 
ATOM   2855 O  O   . LEU   A 1 360 ? -22.184 -115.565 -6.680  1.00 74.51  ? 361  LEU   A O   1 
ATOM   2856 C  CB  . LEU   A 1 360 ? -23.520 -115.828 -9.405  1.00 77.68  ? 361  LEU   A CB  1 
ATOM   2857 C  CG  . LEU   A 1 360 ? -23.679 -114.436 -10.020 1.00 80.16  ? 361  LEU   A CG  1 
ATOM   2858 C  CD1 . LEU   A 1 360 ? -24.784 -114.429 -11.063 1.00 79.70  ? 361  LEU   A CD1 1 
ATOM   2859 C  CD2 . LEU   A 1 360 ? -23.956 -113.382 -8.955  1.00 82.53  ? 361  LEU   A CD2 1 
ATOM   2860 N  N   . MET   A 1 361 ? -20.645 -114.491 -7.965  1.00 73.41  ? 362  MET   A N   1 
ATOM   2861 C  CA  . MET   A 1 361 ? -20.078 -113.646 -6.879  1.00 70.59  ? 362  MET   A CA  1 
ATOM   2862 C  C   . MET   A 1 361 ? -20.153 -112.174 -7.286  1.00 70.50  ? 362  MET   A C   1 
ATOM   2863 O  O   . MET   A 1 361 ? -19.451 -111.787 -8.237  1.00 73.15  ? 362  MET   A O   1 
ATOM   2864 C  CB  . MET   A 1 361 ? -18.627 -114.032 -6.581  1.00 69.02  ? 362  MET   A CB  1 
ATOM   2865 C  CG  . MET   A 1 361 ? -18.475 -115.500 -6.254  1.00 71.42  ? 362  MET   A CG  1 
ATOM   2866 S  SD  . MET   A 1 361 ? -16.942 -115.896 -5.395  1.00 74.18  ? 362  MET   A SD  1 
ATOM   2867 C  CE  . MET   A 1 361 ? -15.777 -114.898 -6.309  1.00 74.47  ? 362  MET   A CE  1 
ATOM   2868 N  N   . VAL   A 1 362 ? -20.986 -111.399 -6.587  1.00 71.95  ? 363  VAL   A N   1 
ATOM   2869 C  CA  . VAL   A 1 362 ? -21.067 -109.914 -6.722  1.00 70.36  ? 363  VAL   A CA  1 
ATOM   2870 C  C   . VAL   A 1 362 ? -19.881 -109.299 -5.967  1.00 69.93  ? 363  VAL   A C   1 
ATOM   2871 O  O   . VAL   A 1 362 ? -19.890 -109.346 -4.719  1.00 69.64  ? 363  VAL   A O   1 
ATOM   2872 C  CB  . VAL   A 1 362 ? -22.403 -109.357 -6.201  1.00 68.22  ? 363  VAL   A CB  1 
ATOM   2873 C  CG1 . VAL   A 1 362 ? -22.483 -107.856 -6.414  1.00 68.54  ? 363  VAL   A CG1 1 
ATOM   2874 C  CG2 . VAL   A 1 362 ? -23.601 -110.049 -6.834  1.00 69.08  ? 363  VAL   A CG2 1 
ATOM   2875 N  N   . LEU   A 1 363 ? -18.908 -108.751 -6.701  1.00 67.37  ? 364  LEU   A N   1 
ATOM   2876 C  CA  . LEU   A 1 363 ? -17.686 -108.104 -6.152  1.00 64.58  ? 364  LEU   A CA  1 
ATOM   2877 C  C   . LEU   A 1 363 ? -17.920 -106.590 -6.067  1.00 61.92  ? 364  LEU   A C   1 
ATOM   2878 O  O   . LEU   A 1 363 ? -17.935 -105.930 -7.124  1.00 66.66  ? 364  LEU   A O   1 
ATOM   2879 C  CB  . LEU   A 1 363 ? -16.499 -108.460 -7.052  1.00 63.98  ? 364  LEU   A CB  1 
ATOM   2880 C  CG  . LEU   A 1 363 ? -16.259 -109.956 -7.255  1.00 64.75  ? 364  LEU   A CG  1 
ATOM   2881 C  CD1 . LEU   A 1 363 ? -14.899 -110.206 -7.892  1.00 61.82  ? 364  LEU   A CD1 1 
ATOM   2882 C  CD2 . LEU   A 1 363 ? -16.373 -110.712 -5.938  1.00 67.18  ? 364  LEU   A CD2 1 
ATOM   2883 N  N   . GLY   A 1 364 ? -18.108 -106.075 -4.848  1.00 58.09  ? 365  GLY   A N   1 
ATOM   2884 C  CA  . GLY   A 1 364 ? -18.558 -104.694 -4.586  1.00 59.59  ? 365  GLY   A CA  1 
ATOM   2885 C  C   . GLY   A 1 364 ? -20.072 -104.593 -4.665  1.00 57.48  ? 365  GLY   A C   1 
ATOM   2886 O  O   . GLY   A 1 364 ? -20.572 -103.900 -5.572  1.00 58.75  ? 365  GLY   A O   1 
ATOM   2887 N  N   . ALA   A 1 365 ? -20.768 -105.253 -3.734  1.00 56.04  ? 366  ALA   A N   1 
ATOM   2888 C  CA  . ALA   A 1 365 ? -22.221 -105.552 -3.787  1.00 56.01  ? 366  ALA   A CA  1 
ATOM   2889 C  C   . ALA   A 1 365 ? -23.048 -104.369 -3.276  1.00 55.16  ? 366  ALA   A C   1 
ATOM   2890 O  O   . ALA   A 1 365 ? -24.293 -104.453 -3.348  1.00 57.17  ? 366  ALA   A O   1 
ATOM   2891 C  CB  . ALA   A 1 365 ? -22.515 -106.799 -2.985  1.00 56.98  ? 366  ALA   A CB  1 
ATOM   2892 N  N   . GLY   A 1 366 ? -22.391 -103.325 -2.764  1.00 53.46  ? 367  GLY   A N   1 
ATOM   2893 C  CA  . GLY   A 1 366 ? -23.054 -102.107 -2.268  1.00 55.04  ? 367  GLY   A CA  1 
ATOM   2894 C  C   . GLY   A 1 366 ? -24.156 -102.452 -1.286  1.00 56.41  ? 367  GLY   A C   1 
ATOM   2895 O  O   . GLY   A 1 366 ? -23.868 -103.177 -0.312  1.00 53.89  ? 367  GLY   A O   1 
ATOM   2896 N  N   . ARG   A 1 367 ? -25.378 -101.985 -1.552  1.00 57.57  ? 368  ARG   A N   1 
ATOM   2897 C  CA  . ARG   A 1 367 ? -26.545 -102.136 -0.643  1.00 62.62  ? 368  ARG   A CA  1 
ATOM   2898 C  C   . ARG   A 1 367 ? -27.466 -103.271 -1.119  1.00 67.43  ? 368  ARG   A C   1 
ATOM   2899 O  O   . ARG   A 1 367 ? -28.526 -103.452 -0.483  1.00 72.45  ? 368  ARG   A O   1 
ATOM   2900 C  CB  . ARG   A 1 367 ? -27.308 -100.810 -0.551  1.00 61.94  ? 368  ARG   A CB  1 
ATOM   2901 C  CG  . ARG   A 1 367 ? -26.506 -99.669  0.059   1.00 61.07  ? 368  ARG   A CG  1 
ATOM   2902 C  CD  . ARG   A 1 367 ? -27.390 -98.557  0.595   1.00 59.91  ? 368  ARG   A CD  1 
ATOM   2903 N  NE  . ARG   A 1 367 ? -28.248 -97.961  -0.421  1.00 59.27  ? 368  ARG   A NE  1 
ATOM   2904 C  CZ  . ARG   A 1 367 ? -29.225 -97.086  -0.178  1.00 61.10  ? 368  ARG   A CZ  1 
ATOM   2905 N  NH1 . ARG   A 1 367 ? -29.945 -96.599  -1.176  1.00 63.37  ? 368  ARG   A NH1 1 
ATOM   2906 N  NH2 . ARG   A 1 367 ? -29.485 -96.693  1.056   1.00 60.81  ? 368  ARG   A NH2 1 
ATOM   2907 N  N   . GLY   A 1 368 ? -27.103 -103.990 -2.192  1.00 68.59  ? 369  GLY   A N   1 
ATOM   2908 C  CA  . GLY   A 1 368 ? -27.791 -105.227 -2.614  1.00 71.61  ? 369  GLY   A CA  1 
ATOM   2909 C  C   . GLY   A 1 368 ? -28.414 -105.208 -4.015  1.00 74.93  ? 369  GLY   A C   1 
ATOM   2910 O  O   . GLY   A 1 368 ? -28.488 -106.262 -4.643  1.00 73.63  ? 369  GLY   A O   1 
ATOM   2911 N  N   . PRO   A 1 369 ? -28.917 -104.074 -4.567  1.00 75.83  ? 370  PRO   A N   1 
ATOM   2912 C  CA  . PRO   A 1 369 ? -29.699 -104.119 -5.808  1.00 74.16  ? 370  PRO   A CA  1 
ATOM   2913 C  C   . PRO   A 1 369 ? -29.082 -104.940 -6.957  1.00 70.69  ? 370  PRO   A C   1 
ATOM   2914 O  O   . PRO   A 1 369 ? -29.837 -105.449 -7.764  1.00 68.87  ? 370  PRO   A O   1 
ATOM   2915 C  CB  . PRO   A 1 369 ? -29.858 -102.652 -6.239  1.00 74.19  ? 370  PRO   A CB  1 
ATOM   2916 C  CG  . PRO   A 1 369 ? -29.002 -101.846 -5.279  1.00 77.18  ? 370  PRO   A CG  1 
ATOM   2917 C  CD  . PRO   A 1 369 ? -28.788 -102.705 -4.051  1.00 76.06  ? 370  PRO   A CD  1 
ATOM   2918 N  N   . LEU   A 1 370 ? -27.753 -105.064 -7.011  1.00 70.31  ? 371  LEU   A N   1 
ATOM   2919 C  CA  . LEU   A 1 370 ? -27.047 -105.913 -8.009  1.00 73.22  ? 371  LEU   A CA  1 
ATOM   2920 C  C   . LEU   A 1 370 ? -27.156 -107.392 -7.607  1.00 73.26  ? 371  LEU   A C   1 
ATOM   2921 O  O   . LEU   A 1 370 ? -27.200 -108.245 -8.517  1.00 72.70  ? 371  LEU   A O   1 
ATOM   2922 C  CB  . LEU   A 1 370 ? -25.583 -105.471 -8.112  1.00 74.40  ? 371  LEU   A CB  1 
ATOM   2923 C  CG  . LEU   A 1 370 ? -24.781 -106.092 -9.256  1.00 76.58  ? 371  LEU   A CG  1 
ATOM   2924 C  CD1 . LEU   A 1 370 ? -25.443 -105.832 -10.601 1.00 77.14  ? 371  LEU   A CD1 1 
ATOM   2925 C  CD2 . LEU   A 1 370 ? -23.358 -105.559 -9.262  1.00 79.77  ? 371  LEU   A CD2 1 
ATOM   2926 N  N   . VAL   A 1 371 ? -27.168 -107.686 -6.300  1.00 73.83  ? 372  VAL   A N   1 
ATOM   2927 C  CA  . VAL   A 1 371 ? -27.446 -109.044 -5.738  1.00 72.27  ? 372  VAL   A CA  1 
ATOM   2928 C  C   . VAL   A 1 371 ? -28.879 -109.432 -6.130  1.00 71.96  ? 372  VAL   A C   1 
ATOM   2929 O  O   . VAL   A 1 371 ? -29.063 -110.543 -6.657  1.00 71.78  ? 372  VAL   A O   1 
ATOM   2930 C  CB  . VAL   A 1 371 ? -27.228 -109.096 -4.211  1.00 71.12  ? 372  VAL   A CB  1 
ATOM   2931 C  CG1 . VAL   A 1 371 ? -27.769 -110.376 -3.589  1.00 69.55  ? 372  VAL   A CG1 1 
ATOM   2932 C  CG2 . VAL   A 1 371 ? -25.763 -108.914 -3.849  1.00 70.57  ? 372  VAL   A CG2 1 
ATOM   2933 N  N   . ASN   A 1 372 ? -29.846 -108.537 -5.904  1.00 70.12  ? 373  ASN   A N   1 
ATOM   2934 C  CA  . ASN   A 1 372 ? -31.254 -108.704 -6.349  1.00 70.71  ? 373  ASN   A CA  1 
ATOM   2935 C  C   . ASN   A 1 372 ? -31.265 -109.006 -7.851  1.00 71.74  ? 373  ASN   A C   1 
ATOM   2936 O  O   . ASN   A 1 372 ? -31.818 -110.050 -8.238  1.00 73.70  ? 373  ASN   A O   1 
ATOM   2937 C  CB  . ASN   A 1 372 ? -32.117 -107.481 -6.026  1.00 71.05  ? 373  ASN   A CB  1 
ATOM   2938 C  CG  . ASN   A 1 372 ? -32.614 -107.464 -4.596  1.00 75.31  ? 373  ASN   A CG  1 
ATOM   2939 O  OD1 . ASN   A 1 372 ? -32.924 -108.508 -4.030  1.00 73.30  ? 373  ASN   A OD1 1 
ATOM   2940 N  ND2 . ASN   A 1 372 ? -32.709 -106.281 -4.009  1.00 82.59  ? 373  ASN   A ND2 1 
ATOM   2941 N  N   . ALA   A 1 373 ? -30.654 -108.136 -8.659  1.00 73.05  ? 374  ALA   A N   1 
ATOM   2942 C  CA  . ALA   A 1 373 ? -30.603 -108.260 -10.134 1.00 70.58  ? 374  ALA   A CA  1 
ATOM   2943 C  C   . ALA   A 1 373 ? -30.096 -109.656 -10.510 1.00 71.70  ? 374  ALA   A C   1 
ATOM   2944 O  O   . ALA   A 1 373 ? -30.682 -110.259 -11.426 1.00 73.06  ? 374  ALA   A O   1 
ATOM   2945 C  CB  . ALA   A 1 373 ? -29.745 -107.172 -10.726 1.00 69.01  ? 374  ALA   A CB  1 
ATOM   2946 N  N   . SER   A 1 374 ? -29.069 -110.155 -9.814  1.00 70.22  ? 375  SER   A N   1 
ATOM   2947 C  CA  . SER   A 1 374 ? -28.467 -111.495 -10.045 1.00 74.94  ? 375  SER   A CA  1 
ATOM   2948 C  C   . SER   A 1 374 ? -29.497 -112.600 -9.762  1.00 79.79  ? 375  SER   A C   1 
ATOM   2949 O  O   . SER   A 1 374 ? -29.461 -113.631 -10.463 1.00 81.67  ? 375  SER   A O   1 
ATOM   2950 C  CB  . SER   A 1 374 ? -27.220 -111.685 -9.220  1.00 74.01  ? 375  SER   A CB  1 
ATOM   2951 O  OG  . SER   A 1 374 ? -26.266 -110.670 -9.498  1.00 73.09  ? 375  SER   A OG  1 
ATOM   2952 N  N   . LEU   A 1 375 ? -30.377 -112.400 -8.775  1.00 80.92  ? 376  LEU   A N   1 
ATOM   2953 C  CA  . LEU   A 1 375 ? -31.437 -113.375 -8.398  1.00 80.37  ? 376  LEU   A CA  1 
ATOM   2954 C  C   . LEU   A 1 375 ? -32.554 -113.349 -9.449  1.00 80.26  ? 376  LEU   A C   1 
ATOM   2955 O  O   . LEU   A 1 375 ? -32.921 -114.437 -9.939  1.00 82.98  ? 376  LEU   A O   1 
ATOM   2956 C  CB  . LEU   A 1 375 ? -31.969 -113.042 -7.001  1.00 81.57  ? 376  LEU   A CB  1 
ATOM   2957 C  CG  . LEU   A 1 375 ? -30.964 -113.184 -5.858  1.00 84.06  ? 376  LEU   A CG  1 
ATOM   2958 C  CD1 . LEU   A 1 375 ? -31.609 -112.839 -4.522  1.00 86.18  ? 376  LEU   A CD1 1 
ATOM   2959 C  CD2 . LEU   A 1 375 ? -30.369 -114.585 -5.814  1.00 84.45  ? 376  LEU   A CD2 1 
ATOM   2960 N  N   . ARG   A 1 376 ? -33.065 -112.158 -9.782  1.00 78.03  ? 377  ARG   A N   1 
ATOM   2961 C  CA  . ARG   A 1 376 ? -34.072 -111.939 -10.860 1.00 77.89  ? 377  ARG   A CA  1 
ATOM   2962 C  C   . ARG   A 1 376 ? -33.601 -112.619 -12.157 1.00 78.64  ? 377  ARG   A C   1 
ATOM   2963 O  O   . ARG   A 1 376 ? -34.461 -113.111 -12.909 1.00 76.14  ? 377  ARG   A O   1 
ATOM   2964 C  CB  . ARG   A 1 376 ? -34.314 -110.442 -11.091 1.00 77.52  ? 377  ARG   A CB  1 
ATOM   2965 C  CG  . ARG   A 1 376 ? -35.459 -109.850 -10.282 1.00 76.25  ? 377  ARG   A CG  1 
ATOM   2966 C  CD  . ARG   A 1 376 ? -35.736 -108.399 -10.641 1.00 80.74  ? 377  ARG   A CD  1 
ATOM   2967 N  NE  . ARG   A 1 376 ? -34.899 -107.467 -9.887  1.00 89.33  ? 377  ARG   A NE  1 
ATOM   2968 C  CZ  . ARG   A 1 376 ? -33.810 -106.843 -10.342 1.00 93.12  ? 377  ARG   A CZ  1 
ATOM   2969 N  NH1 . ARG   A 1 376 ? -33.386 -107.029 -11.581 1.00 99.90  ? 377  ARG   A NH1 1 
ATOM   2970 N  NH2 . ARG   A 1 376 ? -33.140 -106.026 -9.547  1.00 92.86  ? 377  ARG   A NH2 1 
ATOM   2971 N  N   . ALA   A 1 377 ? -32.287 -112.642 -12.404 1.00 83.52  ? 378  ALA   A N   1 
ATOM   2972 C  CA  . ALA   A 1 377 ? -31.648 -113.229 -13.608 1.00 85.26  ? 378  ALA   A CA  1 
ATOM   2973 C  C   . ALA   A 1 377 ? -31.728 -114.758 -13.559 1.00 84.98  ? 378  ALA   A C   1 
ATOM   2974 O  O   . ALA   A 1 377 ? -32.100 -115.365 -14.582 1.00 83.04  ? 378  ALA   A O   1 
ATOM   2975 C  CB  . ALA   A 1 377 ? -30.214 -112.764 -13.716 1.00 83.67  ? 378  ALA   A CB  1 
ATOM   2976 N  N   . ALA   A 1 378 ? -31.373 -115.352 -12.417 1.00 87.45  ? 379  ALA   A N   1 
ATOM   2977 C  CA  . ALA   A 1 378 ? -31.325 -116.818 -12.204 1.00 88.63  ? 379  ALA   A CA  1 
ATOM   2978 C  C   . ALA   A 1 378 ? -32.740 -117.409 -12.275 1.00 92.26  ? 379  ALA   A C   1 
ATOM   2979 O  O   . ALA   A 1 378 ? -32.884 -118.527 -12.813 1.00 91.55  ? 379  ALA   A O   1 
ATOM   2980 C  CB  . ALA   A 1 378 ? -30.656 -117.125 -10.887 1.00 86.35  ? 379  ALA   A CB  1 
ATOM   2981 N  N   . LYS   A 1 379 ? -33.746 -116.690 -11.767 1.00 92.37  ? 380  LYS   A N   1 
ATOM   2982 C  CA  . LYS   A 1 379 ? -35.157 -117.154 -11.774 1.00 96.82  ? 380  LYS   A CA  1 
ATOM   2983 C  C   . LYS   A 1 379 ? -35.673 -117.169 -13.219 1.00 96.59  ? 380  LYS   A C   1 
ATOM   2984 O  O   . LYS   A 1 379 ? -36.105 -118.248 -13.667 1.00 101.67 ? 380  LYS   A O   1 
ATOM   2985 C  CB  . LYS   A 1 379 ? -36.043 -116.301 -10.861 1.00 100.48 ? 380  LYS   A CB  1 
ATOM   2986 C  CG  . LYS   A 1 379 ? -37.415 -116.906 -10.587 1.00 106.30 ? 380  LYS   A CG  1 
ATOM   2987 C  CD  . LYS   A 1 379 ? -38.088 -116.395 -9.333  1.00 110.49 ? 380  LYS   A CD  1 
ATOM   2988 C  CE  . LYS   A 1 379 ? -38.647 -114.997 -9.488  1.00 111.49 ? 380  LYS   A CE  1 
ATOM   2989 N  NZ  . LYS   A 1 379 ? -39.478 -114.616 -8.323  1.00 111.77 ? 380  LYS   A NZ  1 
ATOM   2990 N  N   . GLN   A 1 380 ? -35.599 -116.039 -13.933 1.00 94.73  ? 381  GLN   A N   1 
ATOM   2991 C  CA  . GLN   A 1 380 ? -36.182 -115.894 -15.299 1.00 94.89  ? 381  GLN   A CA  1 
ATOM   2992 C  C   . GLN   A 1 380 ? -35.423 -116.797 -16.286 1.00 90.77  ? 381  GLN   A C   1 
ATOM   2993 O  O   . GLN   A 1 380 ? -36.010 -117.134 -17.332 1.00 84.37  ? 381  GLN   A O   1 
ATOM   2994 C  CB  . GLN   A 1 380 ? -36.212 -114.429 -15.751 1.00 97.14  ? 381  GLN   A CB  1 
ATOM   2995 C  CG  . GLN   A 1 380 ? -34.995 -113.985 -16.556 1.00 99.22  ? 381  GLN   A CG  1 
ATOM   2996 C  CD  . GLN   A 1 380 ? -35.184 -112.645 -17.230 1.00 99.70  ? 381  GLN   A CD  1 
ATOM   2997 O  OE1 . GLN   A 1 380 ? -36.295 -112.133 -17.351 1.00 98.32  ? 381  GLN   A OE1 1 
ATOM   2998 N  NE2 . GLN   A 1 380 ? -34.086 -112.062 -17.685 1.00 100.83 ? 381  GLN   A NE2 1 
ATOM   2999 N  N   . ALA   A 1 381 ? -34.177 -117.172 -15.969 1.00 88.69  ? 382  ALA   A N   1 
ATOM   3000 C  CA  . ALA   A 1 381 ? -33.348 -118.123 -16.750 1.00 89.92  ? 382  ALA   A CA  1 
ATOM   3001 C  C   . ALA   A 1 381 ? -33.691 -119.566 -16.364 1.00 94.00  ? 382  ALA   A C   1 
ATOM   3002 O  O   . ALA   A 1 381 ? -33.343 -120.481 -17.140 1.00 95.61  ? 382  ALA   A O   1 
ATOM   3003 C  CB  . ALA   A 1 381 ? -31.881 -117.847 -16.523 1.00 88.96  ? 382  ALA   A CB  1 
ATOM   3004 N  N   . ASP   A 1 382 ? -34.329 -119.755 -15.203 1.00 97.27  ? 383  ASP   A N   1 
ATOM   3005 C  CA  . ASP   A 1 382 ? -34.626 -121.078 -14.590 1.00 100.05 ? 383  ASP   A CA  1 
ATOM   3006 C  C   . ASP   A 1 382 ? -33.312 -121.863 -14.472 1.00 101.60 ? 383  ASP   A C   1 
ATOM   3007 O  O   . ASP   A 1 382 ? -33.200 -122.956 -15.067 1.00 101.65 ? 383  ASP   A O   1 
ATOM   3008 C  CB  . ASP   A 1 382 ? -35.721 -121.820 -15.363 1.00 99.97  ? 383  ASP   A CB  1 
ATOM   3009 C  CG  . ASP   A 1 382 ? -36.507 -122.795 -14.502 1.00 98.19  ? 383  ASP   A CG  1 
ATOM   3010 O  OD1 . ASP   A 1 382 ? -35.889 -123.739 -13.967 1.00 95.36  ? 383  ASP   A OD1 1 
ATOM   3011 O  OD2 . ASP   A 1 382 ? -37.727 -122.587 -14.354 1.00 96.77  ? 383  ASP   A OD2 1 
ATOM   3012 N  N   . ARG   A 1 383 ? -32.349 -121.289 -13.745 1.00 101.54 ? 384  ARG   A N   1 
ATOM   3013 C  CA  . ARG   A 1 383 ? -31.060 -121.926 -13.365 1.00 98.11  ? 384  ARG   A CA  1 
ATOM   3014 C  C   . ARG   A 1 383 ? -30.805 -121.661 -11.877 1.00 95.34  ? 384  ARG   A C   1 
ATOM   3015 O  O   . ARG   A 1 383 ? -31.293 -120.633 -11.366 1.00 91.77  ? 384  ARG   A O   1 
ATOM   3016 C  CB  . ARG   A 1 383 ? -29.927 -121.385 -14.241 1.00 99.93  ? 384  ARG   A CB  1 
ATOM   3017 C  CG  . ARG   A 1 383 ? -30.068 -121.724 -15.718 1.00 103.05 ? 384  ARG   A CG  1 
ATOM   3018 C  CD  . ARG   A 1 383 ? -30.047 -123.223 -15.959 1.00 104.74 ? 384  ARG   A CD  1 
ATOM   3019 N  NE  . ARG   A 1 383 ? -29.965 -123.578 -17.370 1.00 101.53 ? 384  ARG   A NE  1 
ATOM   3020 C  CZ  . ARG   A 1 383 ? -30.977 -123.539 -18.232 1.00 101.07 ? 384  ARG   A CZ  1 
ATOM   3021 N  NH1 . ARG   A 1 383 ? -32.180 -123.142 -17.850 1.00 98.08  ? 384  ARG   A NH1 1 
ATOM   3022 N  NH2 . ARG   A 1 383 ? -30.775 -123.893 -19.489 1.00 104.46 ? 384  ARG   A NH2 1 
ATOM   3023 N  N   . ARG   A 1 384 ? -30.089 -122.568 -11.209 1.00 96.50  ? 385  ARG   A N   1 
ATOM   3024 C  CA  . ARG   A 1 384 ? -29.801 -122.497 -9.752  1.00 99.05  ? 385  ARG   A CA  1 
ATOM   3025 C  C   . ARG   A 1 384 ? -28.425 -121.847 -9.551  1.00 95.01  ? 385  ARG   A C   1 
ATOM   3026 O  O   . ARG   A 1 384 ? -27.476 -122.232 -10.269 1.00 89.67  ? 385  ARG   A O   1 
ATOM   3027 C  CB  . ARG   A 1 384 ? -29.903 -123.894 -9.128  1.00 104.77 ? 385  ARG   A CB  1 
ATOM   3028 C  CG  . ARG   A 1 384 ? -31.331 -124.403 -8.968  1.00 103.90 ? 385  ARG   A CG  1 
ATOM   3029 C  CD  . ARG   A 1 384 ? -31.378 -125.813 -8.408  1.00 105.96 ? 385  ARG   A CD  1 
ATOM   3030 N  NE  . ARG   A 1 384 ? -30.591 -125.936 -7.185  1.00 108.79 ? 385  ARG   A NE  1 
ATOM   3031 C  CZ  . ARG   A 1 384 ? -29.972 -127.042 -6.768  1.00 110.81 ? 385  ARG   A CZ  1 
ATOM   3032 N  NH1 . ARG   A 1 384 ? -30.028 -128.162 -7.472  1.00 113.88 ? 385  ARG   A NH1 1 
ATOM   3033 N  NH2 . ARG   A 1 384 ? -29.285 -127.019 -5.640  1.00 109.68 ? 385  ARG   A NH2 1 
ATOM   3034 N  N   . ILE   A 1 385 ? -28.332 -120.886 -8.624  1.00 91.75  ? 386  ILE   A N   1 
ATOM   3035 C  CA  . ILE   A 1 385 ? -27.098 -120.086 -8.355  1.00 87.92  ? 386  ILE   A CA  1 
ATOM   3036 C  C   . ILE   A 1 385 ? -26.819 -120.045 -6.846  1.00 86.69  ? 386  ILE   A C   1 
ATOM   3037 O  O   . ILE   A 1 385 ? -27.765 -119.806 -6.061  1.00 83.89  ? 386  ILE   A O   1 
ATOM   3038 C  CB  . ILE   A 1 385 ? -27.212 -118.665 -8.948  1.00 84.14  ? 386  ILE   A CB  1 
ATOM   3039 C  CG1 . ILE   A 1 385 ? -28.426 -117.902 -8.408  1.00 84.79  ? 386  ILE   A CG1 1 
ATOM   3040 C  CG2 . ILE   A 1 385 ? -27.220 -118.721 -10.467 1.00 83.89  ? 386  ILE   A CG2 1 
ATOM   3041 C  CD1 . ILE   A 1 385 ? -28.318 -116.400 -8.529  1.00 84.51  ? 386  ILE   A CD1 1 
ATOM   3042 N  N   . LYS   A 1 386 ? -25.560 -120.277 -6.465  1.00 84.68  ? 387  LYS   A N   1 
ATOM   3043 C  CA  . LYS   A 1 386 ? -25.016 -119.952 -5.121  1.00 85.81  ? 387  LYS   A CA  1 
ATOM   3044 C  C   . LYS   A 1 386 ? -24.352 -118.575 -5.211  1.00 84.97  ? 387  LYS   A C   1 
ATOM   3045 O  O   . LYS   A 1 386 ? -23.401 -118.440 -6.003  1.00 88.12  ? 387  LYS   A O   1 
ATOM   3046 C  CB  . LYS   A 1 386 ? -24.023 -121.025 -4.669  1.00 85.71  ? 387  LYS   A CB  1 
ATOM   3047 C  CG  . LYS   A 1 386 ? -23.710 -121.024 -3.180  1.00 89.49  ? 387  LYS   A CG  1 
ATOM   3048 C  CD  . LYS   A 1 386 ? -22.612 -121.997 -2.819  1.00 93.96  ? 387  LYS   A CD  1 
ATOM   3049 C  CE  . LYS   A 1 386 ? -22.597 -122.387 -1.356  1.00 98.38  ? 387  LYS   A CE  1 
ATOM   3050 N  NZ  . LYS   A 1 386 ? -21.878 -123.666 -1.142  1.00 99.63  ? 387  LYS   A NZ  1 
ATOM   3051 N  N   . LEU   A 1 387 ? -24.840 -117.598 -4.440  1.00 83.58  ? 388  LEU   A N   1 
ATOM   3052 C  CA  . LEU   A 1 387 ? -24.450 -116.167 -4.564  1.00 81.38  ? 388  LEU   A CA  1 
ATOM   3053 C  C   . LEU   A 1 387 ? -23.589 -115.742 -3.368  1.00 79.86  ? 388  LEU   A C   1 
ATOM   3054 O  O   . LEU   A 1 387 ? -24.004 -115.985 -2.218  1.00 80.55  ? 388  LEU   A O   1 
ATOM   3055 C  CB  . LEU   A 1 387 ? -25.722 -115.321 -4.676  1.00 81.79  ? 388  LEU   A CB  1 
ATOM   3056 C  CG  . LEU   A 1 387 ? -25.535 -113.930 -5.280  1.00 85.30  ? 388  LEU   A CG  1 
ATOM   3057 C  CD1 . LEU   A 1 387 ? -26.822 -113.442 -5.927  1.00 84.33  ? 388  LEU   A CD1 1 
ATOM   3058 C  CD2 . LEU   A 1 387 ? -25.059 -112.933 -4.233  1.00 88.22  ? 388  LEU   A CD2 1 
ATOM   3059 N  N   . TYR   A 1 388 ? -22.426 -115.139 -3.643  1.00 77.63  ? 389  TYR   A N   1 
ATOM   3060 C  CA  . TYR   A 1 388 ? -21.564 -114.435 -2.656  1.00 76.62  ? 389  TYR   A CA  1 
ATOM   3061 C  C   . TYR   A 1 388 ? -21.653 -112.925 -2.905  1.00 73.31  ? 389  TYR   A C   1 
ATOM   3062 O  O   . TYR   A 1 388 ? -21.455 -112.503 -4.059  1.00 74.25  ? 389  TYR   A O   1 
ATOM   3063 C  CB  . TYR   A 1 388 ? -20.114 -114.906 -2.758  1.00 78.69  ? 389  TYR   A CB  1 
ATOM   3064 C  CG  . TYR   A 1 388 ? -19.873 -116.293 -2.225  1.00 85.03  ? 389  TYR   A CG  1 
ATOM   3065 C  CD1 . TYR   A 1 388 ? -20.072 -117.409 -3.021  1.00 87.05  ? 389  TYR   A CD1 1 
ATOM   3066 C  CD2 . TYR   A 1 388 ? -19.446 -116.490 -0.921  1.00 88.54  ? 389  TYR   A CD2 1 
ATOM   3067 C  CE1 . TYR   A 1 388 ? -19.854 -118.688 -2.535  1.00 89.10  ? 389  TYR   A CE1 1 
ATOM   3068 C  CE2 . TYR   A 1 388 ? -19.220 -117.761 -0.420  1.00 88.83  ? 389  TYR   A CE2 1 
ATOM   3069 C  CZ  . TYR   A 1 388 ? -19.425 -118.864 -1.230  1.00 91.85  ? 389  TYR   A CZ  1 
ATOM   3070 O  OH  . TYR   A 1 388 ? -19.202 -120.120 -0.745  1.00 96.48  ? 389  TYR   A OH  1 
ATOM   3071 N  N   . ALA   A 1 389 ? -21.954 -112.150 -1.858  1.00 68.15  ? 390  ALA   A N   1 
ATOM   3072 C  CA  . ALA   A 1 389 ? -22.028 -110.670 -1.884  1.00 67.19  ? 390  ALA   A CA  1 
ATOM   3073 C  C   . ALA   A 1 389 ? -20.835 -110.090 -1.113  1.00 63.78  ? 390  ALA   A C   1 
ATOM   3074 O  O   . ALA   A 1 389 ? -20.935 -109.955 0.118   1.00 64.28  ? 390  ALA   A O   1 
ATOM   3075 C  CB  . ALA   A 1 389 ? -23.349 -110.208 -1.315  1.00 65.89  ? 390  ALA   A CB  1 
ATOM   3076 N  N   . VAL   A 1 390 ? -19.747 -109.770 -1.821  1.00 62.72  ? 391  VAL   A N   1 
ATOM   3077 C  CA  . VAL   A 1 390 ? -18.487 -109.216 -1.239  1.00 63.98  ? 391  VAL   A CA  1 
ATOM   3078 C  C   . VAL   A 1 390 ? -18.560 -107.687 -1.271  1.00 63.64  ? 391  VAL   A C   1 
ATOM   3079 O  O   . VAL   A 1 390 ? -18.739 -107.131 -2.372  1.00 68.38  ? 391  VAL   A O   1 
ATOM   3080 C  CB  . VAL   A 1 390 ? -17.240 -109.713 -1.991  1.00 65.73  ? 391  VAL   A CB  1 
ATOM   3081 C  CG1 . VAL   A 1 390 ? -15.963 -109.304 -1.275  1.00 66.94  ? 391  VAL   A CG1 1 
ATOM   3082 C  CG2 . VAL   A 1 390 ? -17.271 -111.216 -2.213  1.00 68.25  ? 391  VAL   A CG2 1 
ATOM   3083 N  N   . GLU   A 1 391 ? -18.416 -107.043 -0.110  1.00 61.17  ? 392  GLU   A N   1 
ATOM   3084 C  CA  . GLU   A 1 391 ? -18.462 -105.564 0.049   1.00 61.16  ? 392  GLU   A CA  1 
ATOM   3085 C  C   . GLU   A 1 391 ? -17.449 -105.150 1.120   1.00 62.07  ? 392  GLU   A C   1 
ATOM   3086 O  O   . GLU   A 1 391 ? -17.409 -105.807 2.183   1.00 63.78  ? 392  GLU   A O   1 
ATOM   3087 C  CB  . GLU   A 1 391 ? -19.881 -105.113 0.403   1.00 59.24  ? 392  GLU   A CB  1 
ATOM   3088 C  CG  . GLU   A 1 391 ? -20.005 -103.616 0.633   1.00 59.76  ? 392  GLU   A CG  1 
ATOM   3089 C  CD  . GLU   A 1 391 ? -19.489 -102.745 -0.502  1.00 59.79  ? 392  GLU   A CD  1 
ATOM   3090 O  OE1 . GLU   A 1 391 ? -20.039 -102.838 -1.618  1.00 58.28  ? 392  GLU   A OE1 1 
ATOM   3091 O  OE2 . GLU   A 1 391 ? -18.532 -101.982 -0.270  1.00 56.28  ? 392  GLU   A OE2 1 
ATOM   3092 N  N   . LYS   A 1 392 ? -16.652 -104.117 0.837   1.00 61.80  ? 393  LYS   A N   1 
ATOM   3093 C  CA  . LYS   A 1 392 ? -15.585 -103.609 1.746   1.00 59.26  ? 393  LYS   A CA  1 
ATOM   3094 C  C   . LYS   A 1 392 ? -16.166 -102.528 2.664   1.00 54.45  ? 393  LYS   A C   1 
ATOM   3095 O  O   . LYS   A 1 392 ? -15.653 -102.375 3.776   1.00 51.73  ? 393  LYS   A O   1 
ATOM   3096 C  CB  . LYS   A 1 392 ? -14.398 -103.053 0.951   1.00 62.77  ? 393  LYS   A CB  1 
ATOM   3097 C  CG  . LYS   A 1 392 ? -14.705 -101.849 0.068   1.00 64.63  ? 393  LYS   A CG  1 
ATOM   3098 C  CD  . LYS   A 1 392 ? -13.831 -100.648 0.341   1.00 67.67  ? 393  LYS   A CD  1 
ATOM   3099 C  CE  . LYS   A 1 392 ? -14.495 -99.347  -0.054  1.00 69.31  ? 393  LYS   A CE  1 
ATOM   3100 N  NZ  . LYS   A 1 392 ? -13.732 -98.171  0.430   1.00 69.83  ? 393  LYS   A NZ  1 
ATOM   3101 N  N   . ASN   A 1 393 ? -17.180 -101.797 2.196   1.00 54.13  ? 394  ASN   A N   1 
ATOM   3102 C  CA  . ASN   A 1 393 ? -17.828 -100.686 2.938   1.00 54.22  ? 394  ASN   A CA  1 
ATOM   3103 C  C   . ASN   A 1 393 ? -18.665 -101.275 4.070   1.00 56.28  ? 394  ASN   A C   1 
ATOM   3104 O  O   . ASN   A 1 393 ? -19.800 -101.692 3.844   1.00 56.92  ? 394  ASN   A O   1 
ATOM   3105 C  CB  . ASN   A 1 393 ? -18.672 -99.810  2.010   1.00 53.43  ? 394  ASN   A CB  1 
ATOM   3106 C  CG  . ASN   A 1 393 ? -19.234 -98.591  2.706   1.00 53.80  ? 394  ASN   A CG  1 
ATOM   3107 O  OD1 . ASN   A 1 393 ? -19.144 -98.477  3.926   1.00 54.90  ? 394  ASN   A OD1 1 
ATOM   3108 N  ND2 . ASN   A 1 393 ? -19.807 -97.674  1.942   1.00 54.32  ? 394  ASN   A ND2 1 
ATOM   3109 N  N   . PRO   A 1 394 ? -18.158 -101.298 5.327   1.00 58.04  ? 395  PRO   A N   1 
ATOM   3110 C  CA  . PRO   A 1 394 ? -18.867 -101.955 6.426   1.00 57.28  ? 395  PRO   A CA  1 
ATOM   3111 C  C   . PRO   A 1 394 ? -20.248 -101.335 6.690   1.00 59.08  ? 395  PRO   A C   1 
ATOM   3112 O  O   . PRO   A 1 394 ? -21.105 -102.025 7.220   1.00 65.26  ? 395  PRO   A O   1 
ATOM   3113 C  CB  . PRO   A 1 394 ? -17.932 -101.777 7.633   1.00 55.31  ? 395  PRO   A CB  1 
ATOM   3114 C  CG  . PRO   A 1 394 ? -17.098 -100.571 7.278   1.00 55.70  ? 395  PRO   A CG  1 
ATOM   3115 C  CD  . PRO   A 1 394 ? -16.912 -100.656 5.779   1.00 55.99  ? 395  PRO   A CD  1 
ATOM   3116 N  N   . ASN   A 1 395 ? -20.438 -100.071 6.304   1.00 57.76  ? 396  ASN   A N   1 
ATOM   3117 C  CA  . ASN   A 1 395 ? -21.705 -99.320  6.508   1.00 61.39  ? 396  ASN   A CA  1 
ATOM   3118 C  C   . ASN   A 1 395 ? -22.785 -99.880  5.575   1.00 63.87  ? 396  ASN   A C   1 
ATOM   3119 O  O   . ASN   A 1 395 ? -23.948 -99.965  6.006   1.00 68.61  ? 396  ASN   A O   1 
ATOM   3120 C  CB  . ASN   A 1 395 ? -21.513 -97.817  6.293   1.00 62.99  ? 396  ASN   A CB  1 
ATOM   3121 C  CG  . ASN   A 1 395 ? -20.372 -97.237  7.101   1.00 62.55  ? 396  ASN   A CG  1 
ATOM   3122 O  OD1 . ASN   A 1 395 ? -20.551 -96.874  8.260   1.00 67.39  ? 396  ASN   A OD1 1 
ATOM   3123 N  ND2 . ASN   A 1 395 ? -19.197 -97.139  6.501   1.00 61.27  ? 396  ASN   A ND2 1 
ATOM   3124 N  N   . ALA   A 1 396 ? -22.414 -100.228 4.340   1.00 66.66  ? 397  ALA   A N   1 
ATOM   3125 C  CA  . ALA   A 1 396 ? -23.299 -100.867 3.335   1.00 66.81  ? 397  ALA   A CA  1 
ATOM   3126 C  C   . ALA   A 1 396 ? -23.480 -102.352 3.682   1.00 67.52  ? 397  ALA   A C   1 
ATOM   3127 O  O   . ALA   A 1 396 ? -24.602 -102.865 3.505   1.00 69.10  ? 397  ALA   A O   1 
ATOM   3128 C  CB  . ALA   A 1 396 ? -22.728 -100.682 1.951   1.00 65.97  ? 397  ALA   A CB  1 
ATOM   3129 N  N   . VAL   A 1 397 ? -22.417 -103.007 4.166   1.00 63.28  ? 398  VAL   A N   1 
ATOM   3130 C  CA  . VAL   A 1 397 ? -22.438 -104.406 4.690   1.00 63.58  ? 398  VAL   A CA  1 
ATOM   3131 C  C   . VAL   A 1 397 ? -23.541 -104.536 5.750   1.00 63.90  ? 398  VAL   A C   1 
ATOM   3132 O  O   . VAL   A 1 397 ? -24.111 -105.635 5.871   1.00 65.85  ? 398  VAL   A O   1 
ATOM   3133 C  CB  . VAL   A 1 397 ? -21.065 -104.812 5.258   1.00 65.02  ? 398  VAL   A CB  1 
ATOM   3134 C  CG1 . VAL   A 1 397 ? -21.144 -106.033 6.168   1.00 64.84  ? 398  VAL   A CG1 1 
ATOM   3135 C  CG2 . VAL   A 1 397 ? -20.048 -105.041 4.149   1.00 66.40  ? 398  VAL   A CG2 1 
ATOM   3136 N  N   . VAL   A 1 398 ? -23.820 -103.469 6.502   1.00 64.19  ? 399  VAL   A N   1 
ATOM   3137 C  CA  . VAL   A 1 398 ? -24.945 -103.433 7.482   1.00 66.20  ? 399  VAL   A CA  1 
ATOM   3138 C  C   . VAL   A 1 398 ? -26.254 -103.617 6.707   1.00 67.56  ? 399  VAL   A C   1 
ATOM   3139 O  O   . VAL   A 1 398 ? -27.078 -104.443 7.139   1.00 73.42  ? 399  VAL   A O   1 
ATOM   3140 C  CB  . VAL   A 1 398 ? -24.930 -102.140 8.322   1.00 65.39  ? 399  VAL   A CB  1 
ATOM   3141 C  CG1 . VAL   A 1 398 ? -26.283 -101.834 8.952   1.00 65.18  ? 399  VAL   A CG1 1 
ATOM   3142 C  CG2 . VAL   A 1 398 ? -23.847 -102.192 9.388   1.00 64.92  ? 399  VAL   A CG2 1 
ATOM   3143 N  N   . THR   A 1 399 ? -26.425 -102.893 5.598   1.00 67.73  ? 400  THR   A N   1 
ATOM   3144 C  CA  . THR   A 1 399 ? -27.620 -102.977 4.716   1.00 69.66  ? 400  THR   A CA  1 
ATOM   3145 C  C   . THR   A 1 399 ? -27.745 -104.407 4.172   1.00 67.86  ? 400  THR   A C   1 
ATOM   3146 O  O   . THR   A 1 399 ? -28.839 -104.982 4.278   1.00 66.47  ? 400  THR   A O   1 
ATOM   3147 C  CB  . THR   A 1 399 ? -27.554 -101.942 3.585   1.00 71.78  ? 400  THR   A CB  1 
ATOM   3148 O  OG1 . THR   A 1 399 ? -27.376 -100.653 4.173   1.00 74.42  ? 400  THR   A OG1 1 
ATOM   3149 C  CG2 . THR   A 1 399 ? -28.788 -101.940 2.710   1.00 74.33  ? 400  THR   A CG2 1 
ATOM   3150 N  N   . LEU   A 1 400 ? -26.660 -104.955 3.624   1.00 65.11  ? 401  LEU   A N   1 
ATOM   3151 C  CA  . LEU   A 1 400 ? -26.629 -106.311 3.016   1.00 66.67  ? 401  LEU   A CA  1 
ATOM   3152 C  C   . LEU   A 1 400 ? -27.099 -107.345 4.045   1.00 67.17  ? 401  LEU   A C   1 
ATOM   3153 O  O   . LEU   A 1 400 ? -28.065 -108.068 3.746   1.00 69.36  ? 401  LEU   A O   1 
ATOM   3154 C  CB  . LEU   A 1 400 ? -25.207 -106.623 2.534   1.00 68.52  ? 401  LEU   A CB  1 
ATOM   3155 C  CG  . LEU   A 1 400 ? -24.693 -105.790 1.361   1.00 66.93  ? 401  LEU   A CG  1 
ATOM   3156 C  CD1 . LEU   A 1 400 ? -23.274 -106.194 0.995   1.00 64.74  ? 401  LEU   A CD1 1 
ATOM   3157 C  CD2 . LEU   A 1 400 ? -25.608 -105.919 0.154   1.00 68.11  ? 401  LEU   A CD2 1 
ATOM   3158 N  N   . GLU   A 1 401 ? -26.443 -107.397 5.210   1.00 68.46  ? 402  GLU   A N   1 
ATOM   3159 C  CA  . GLU   A 1 401 ? -26.662 -108.422 6.269   1.00 66.40  ? 402  GLU   A CA  1 
ATOM   3160 C  C   . GLU   A 1 401 ? -28.093 -108.327 6.821   1.00 69.33  ? 402  GLU   A C   1 
ATOM   3161 O  O   . GLU   A 1 401 ? -28.621 -109.379 7.230   1.00 71.64  ? 402  GLU   A O   1 
ATOM   3162 C  CB  . GLU   A 1 401 ? -25.604 -108.289 7.366   1.00 65.14  ? 402  GLU   A CB  1 
ATOM   3163 C  CG  . GLU   A 1 401 ? -24.250 -108.829 6.937   1.00 66.52  ? 402  GLU   A CG  1 
ATOM   3164 C  CD  . GLU   A 1 401 ? -23.165 -108.862 8.002   1.00 67.52  ? 402  GLU   A CD  1 
ATOM   3165 O  OE1 . GLU   A 1 401 ? -23.141 -107.959 8.874   1.00 65.94  ? 402  GLU   A OE1 1 
ATOM   3166 O  OE2 . GLU   A 1 401 ? -22.332 -109.787 7.946   1.00 70.54  ? 402  GLU   A OE2 1 
ATOM   3167 N  N   . ASN   A 1 402 ? -28.705 -107.136 6.818   1.00 70.24  ? 403  ASN   A N   1 
ATOM   3168 C  CA  . ASN   A 1 402 ? -30.136 -106.942 7.186   1.00 74.18  ? 403  ASN   A CA  1 
ATOM   3169 C  C   . ASN   A 1 402 ? -31.036 -107.515 6.079   1.00 79.79  ? 403  ASN   A C   1 
ATOM   3170 O  O   . ASN   A 1 402 ? -32.054 -108.136 6.429   1.00 85.55  ? 403  ASN   A O   1 
ATOM   3171 C  CB  . ASN   A 1 402 ? -30.484 -105.479 7.484   1.00 73.33  ? 403  ASN   A CB  1 
ATOM   3172 C  CG  . ASN   A 1 402 ? -30.410 -105.130 8.957   1.00 74.31  ? 403  ASN   A CG  1 
ATOM   3173 O  OD1 . ASN   A 1 402 ? -31.431 -104.899 9.603   1.00 72.04  ? 403  ASN   A OD1 1 
ATOM   3174 N  ND2 . ASN   A 1 402 ? -29.206 -105.073 9.498   1.00 74.31  ? 403  ASN   A ND2 1 
ATOM   3175 N  N   . TRP   A 1 403 ? -30.693 -107.295 4.801   1.00 83.44  ? 404  TRP   A N   1 
ATOM   3176 C  CA  . TRP   A 1 403 ? -31.368 -107.916 3.625   1.00 83.12  ? 404  TRP   A CA  1 
ATOM   3177 C  C   . TRP   A 1 403 ? -31.227 -109.439 3.723   1.00 83.51  ? 404  TRP   A C   1 
ATOM   3178 O  O   . TRP   A 1 403 ? -32.250 -110.140 3.607   1.00 85.65  ? 404  TRP   A O   1 
ATOM   3179 C  CB  . TRP   A 1 403 ? -30.792 -107.400 2.295   1.00 84.14  ? 404  TRP   A CB  1 
ATOM   3180 C  CG  . TRP   A 1 403 ? -31.603 -106.347 1.602   1.00 86.57  ? 404  TRP   A CG  1 
ATOM   3181 C  CD1 . TRP   A 1 403 ? -31.420 -104.997 1.665   1.00 87.74  ? 404  TRP   A CD1 1 
ATOM   3182 C  CD2 . TRP   A 1 403 ? -32.703 -106.556 0.696   1.00 90.95  ? 404  TRP   A CD2 1 
ATOM   3183 N  NE1 . TRP   A 1 403 ? -32.339 -104.353 0.882   1.00 88.51  ? 404  TRP   A NE1 1 
ATOM   3184 C  CE2 . TRP   A 1 403 ? -33.137 -105.281 0.271   1.00 90.95  ? 404  TRP   A CE2 1 
ATOM   3185 C  CE3 . TRP   A 1 403 ? -33.365 -107.687 0.205   1.00 89.80  ? 404  TRP   A CE3 1 
ATOM   3186 C  CZ2 . TRP   A 1 403 ? -34.203 -105.111 -0.612  1.00 89.04  ? 404  TRP   A CZ2 1 
ATOM   3187 C  CZ3 . TRP   A 1 403 ? -34.418 -107.518 -0.669  1.00 88.44  ? 404  TRP   A CZ3 1 
ATOM   3188 C  CH2 . TRP   A 1 403 ? -34.831 -106.247 -1.069  1.00 87.25  ? 404  TRP   A CH2 1 
ATOM   3189 N  N   . GLN   A 1 404 ? -29.998 -109.917 3.940   1.00 83.76  ? 405  GLN   A N   1 
ATOM   3190 C  CA  . GLN   A 1 404 ? -29.624 -111.359 3.963   1.00 86.87  ? 405  GLN   A CA  1 
ATOM   3191 C  C   . GLN   A 1 404 ? -30.466 -112.111 5.003   1.00 90.21  ? 405  GLN   A C   1 
ATOM   3192 O  O   . GLN   A 1 404 ? -30.838 -113.269 4.729   1.00 88.83  ? 405  GLN   A O   1 
ATOM   3193 C  CB  . GLN   A 1 404 ? -28.129 -111.502 4.255   1.00 86.94  ? 405  GLN   A CB  1 
ATOM   3194 C  CG  . GLN   A 1 404 ? -27.610 -112.932 4.157   1.00 89.57  ? 405  GLN   A CG  1 
ATOM   3195 C  CD  . GLN   A 1 404 ? -28.074 -113.843 5.268   1.00 88.21  ? 405  GLN   A CD  1 
ATOM   3196 O  OE1 . GLN   A 1 404 ? -28.287 -115.033 5.059   1.00 86.10  ? 405  GLN   A OE1 1 
ATOM   3197 N  NE2 . GLN   A 1 404 ? -28.233 -113.298 6.464   1.00 88.92  ? 405  GLN   A NE2 1 
ATOM   3198 N  N   . PHE   A 1 405 ? -30.734 -111.487 6.155   1.00 91.52  ? 406  PHE   A N   1 
ATOM   3199 C  CA  . PHE   A 1 405 ? -31.483 -112.086 7.291   1.00 88.89  ? 406  PHE   A CA  1 
ATOM   3200 C  C   . PHE   A 1 405 ? -32.996 -111.974 7.056   1.00 85.43  ? 406  PHE   A C   1 
ATOM   3201 O  O   . PHE   A 1 405 ? -33.712 -112.948 7.349   1.00 86.48  ? 406  PHE   A O   1 
ATOM   3202 C  CB  . PHE   A 1 405 ? -31.087 -111.430 8.618   1.00 92.96  ? 406  PHE   A CB  1 
ATOM   3203 C  CG  . PHE   A 1 405 ? -32.008 -111.771 9.762   1.00 95.95  ? 406  PHE   A CG  1 
ATOM   3204 C  CD1 . PHE   A 1 405 ? -31.942 -113.012 10.377  1.00 96.58  ? 406  PHE   A CD1 1 
ATOM   3205 C  CD2 . PHE   A 1 405 ? -32.966 -110.867 10.196  1.00 98.46  ? 406  PHE   A CD2 1 
ATOM   3206 C  CE1 . PHE   A 1 405 ? -32.803 -113.333 11.414  1.00 96.07  ? 406  PHE   A CE1 1 
ATOM   3207 C  CE2 . PHE   A 1 405 ? -33.825 -111.190 11.234  1.00 98.31  ? 406  PHE   A CE2 1 
ATOM   3208 C  CZ  . PHE   A 1 405 ? -33.742 -112.421 11.841  1.00 98.54  ? 406  PHE   A CZ  1 
ATOM   3209 N  N   . GLU   A 1 406 ? -33.469 -110.825 6.562   1.00 83.25  ? 407  GLU   A N   1 
ATOM   3210 C  CA  . GLU   A 1 406 ? -34.919 -110.505 6.430   1.00 83.04  ? 407  GLU   A CA  1 
ATOM   3211 C  C   . GLU   A 1 406 ? -35.527 -111.159 5.178   1.00 84.74  ? 407  GLU   A C   1 
ATOM   3212 O  O   . GLU   A 1 406 ? -36.743 -111.443 5.217   1.00 85.97  ? 407  GLU   A O   1 
ATOM   3213 C  CB  . GLU   A 1 406 ? -35.144 -108.992 6.377   1.00 81.70  ? 407  GLU   A CB  1 
ATOM   3214 C  CG  . GLU   A 1 406 ? -35.011 -108.309 7.725   1.00 82.69  ? 407  GLU   A CG  1 
ATOM   3215 C  CD  . GLU   A 1 406 ? -35.240 -106.806 7.698   1.00 84.59  ? 407  GLU   A CD  1 
ATOM   3216 O  OE1 . GLU   A 1 406 ? -34.987 -106.190 6.646   1.00 90.44  ? 407  GLU   A OE1 1 
ATOM   3217 O  OE2 . GLU   A 1 406 ? -35.670 -106.255 8.730   1.00 83.06  ? 407  GLU   A OE2 1 
ATOM   3218 N  N   . GLU   A 1 407 ? -34.745 -111.377 4.111   1.00 84.81  ? 408  GLU   A N   1 
ATOM   3219 C  CA  . GLU   A 1 407 ? -35.282 -111.750 2.770   1.00 83.12  ? 408  GLU   A CA  1 
ATOM   3220 C  C   . GLU   A 1 407 ? -34.480 -112.887 2.124   1.00 79.48  ? 408  GLU   A C   1 
ATOM   3221 O  O   . GLU   A 1 407 ? -35.053 -113.975 1.950   1.00 81.12  ? 408  GLU   A O   1 
ATOM   3222 C  CB  . GLU   A 1 407 ? -35.304 -110.526 1.853   1.00 84.46  ? 408  GLU   A CB  1 
ATOM   3223 C  CG  . GLU   A 1 407 ? -36.214 -109.412 2.346   1.00 87.76  ? 408  GLU   A CG  1 
ATOM   3224 C  CD  . GLU   A 1 407 ? -37.683 -109.777 2.474   1.00 91.74  ? 408  GLU   A CD  1 
ATOM   3225 O  OE1 . GLU   A 1 407 ? -38.096 -110.797 1.884   1.00 97.77  ? 408  GLU   A OE1 1 
ATOM   3226 O  OE2 . GLU   A 1 407 ? -38.411 -109.037 3.161   1.00 96.79  ? 408  GLU   A OE2 1 
ATOM   3227 N  N   . TRP   A 1 408 ? -33.222 -112.642 1.750   1.00 80.93  ? 409  TRP   A N   1 
ATOM   3228 C  CA  . TRP   A 1 408 ? -32.450 -113.504 0.810   1.00 81.51  ? 409  TRP   A CA  1 
ATOM   3229 C  C   . TRP   A 1 408 ? -32.273 -114.921 1.365   1.00 79.47  ? 409  TRP   A C   1 
ATOM   3230 O  O   . TRP   A 1 408 ? -32.190 -115.855 0.548   1.00 82.80  ? 409  TRP   A O   1 
ATOM   3231 C  CB  . TRP   A 1 408 ? -31.087 -112.886 0.468   1.00 82.39  ? 409  TRP   A CB  1 
ATOM   3232 C  CG  . TRP   A 1 408 ? -31.162 -111.553 -0.209  1.00 84.86  ? 409  TRP   A CG  1 
ATOM   3233 C  CD1 . TRP   A 1 408 ? -32.192 -111.063 -0.959  1.00 86.82  ? 409  TRP   A CD1 1 
ATOM   3234 C  CD2 . TRP   A 1 408 ? -30.144 -110.537 -0.214  1.00 86.81  ? 409  TRP   A CD2 1 
ATOM   3235 N  NE1 . TRP   A 1 408 ? -31.893 -109.808 -1.418  1.00 88.18  ? 409  TRP   A NE1 1 
ATOM   3236 C  CE2 . TRP   A 1 408 ? -30.643 -109.458 -0.976  1.00 90.92  ? 409  TRP   A CE2 1 
ATOM   3237 C  CE3 . TRP   A 1 408 ? -28.869 -110.430 0.355   1.00 83.97  ? 409  TRP   A CE3 1 
ATOM   3238 C  CZ2 . TRP   A 1 408 ? -29.907 -108.291 -1.183  1.00 89.23  ? 409  TRP   A CZ2 1 
ATOM   3239 C  CZ3 . TRP   A 1 408 ? -28.143 -109.277 0.149   1.00 85.87  ? 409  TRP   A CZ3 1 
ATOM   3240 C  CH2 . TRP   A 1 408 ? -28.657 -108.224 -0.610  1.00 86.86  ? 409  TRP   A CH2 1 
ATOM   3241 N  N   . GLY   A 1 409 ? -32.178 -115.077 2.687   1.00 79.92  ? 410  GLY   A N   1 
ATOM   3242 C  CA  . GLY   A 1 409 ? -31.838 -116.362 3.327   1.00 83.00  ? 410  GLY   A CA  1 
ATOM   3243 C  C   . GLY   A 1 409 ? -30.428 -116.803 2.964   1.00 85.90  ? 410  GLY   A C   1 
ATOM   3244 O  O   . GLY   A 1 409 ? -29.645 -115.955 2.489   1.00 86.66  ? 410  GLY   A O   1 
ATOM   3245 N  N   . SER   A 1 410 ? -30.117 -118.088 3.153   1.00 88.50  ? 411  SER   A N   1 
ATOM   3246 C  CA  . SER   A 1 410 ? -28.755 -118.665 2.991   1.00 91.26  ? 411  SER   A CA  1 
ATOM   3247 C  C   . SER   A 1 410 ? -28.420 -118.875 1.507   1.00 89.08  ? 411  SER   A C   1 
ATOM   3248 O  O   . SER   A 1 410 ? -27.333 -119.429 1.229   1.00 83.93  ? 411  SER   A O   1 
ATOM   3249 C  CB  . SER   A 1 410 ? -28.606 -119.948 3.778   1.00 95.41  ? 411  SER   A CB  1 
ATOM   3250 O  OG  . SER   A 1 410 ? -29.475 -120.956 3.276   1.00 96.33  ? 411  SER   A OG  1 
ATOM   3251 N  N   . GLN   A 1 411 ? -29.302 -118.461 0.590   1.00 86.50  ? 412  GLN   A N   1 
ATOM   3252 C  CA  . GLN   A 1 411 ? -28.970 -118.353 -0.856  1.00 91.74  ? 412  GLN   A CA  1 
ATOM   3253 C  C   . GLN   A 1 411 ? -27.783 -117.394 -1.018  1.00 91.37  ? 412  GLN   A C   1 
ATOM   3254 O  O   . GLN   A 1 411 ? -26.898 -117.688 -1.855  1.00 86.97  ? 412  GLN   A O   1 
ATOM   3255 C  CB  . GLN   A 1 411 ? -30.166 -117.870 -1.680  1.00 93.98  ? 412  GLN   A CB  1 
ATOM   3256 C  CG  . GLN   A 1 411 ? -29.815 -117.646 -3.147  1.00 98.41  ? 412  GLN   A CG  1 
ATOM   3257 C  CD  . GLN   A 1 411 ? -30.959 -117.901 -4.099  1.00 101.97 ? 412  GLN   A CD  1 
ATOM   3258 O  OE1 . GLN   A 1 411 ? -32.129 -117.716 -3.767  1.00 109.81 ? 412  GLN   A OE1 1 
ATOM   3259 N  NE2 . GLN   A 1 411 ? -30.623 -118.321 -5.309  1.00 97.43  ? 412  GLN   A NE2 1 
ATOM   3260 N  N   . VAL   A 1 412 ? -27.774 -116.303 -0.238  1.00 86.93  ? 413  VAL   A N   1 
ATOM   3261 C  CA  . VAL   A 1 412 ? -26.736 -115.230 -0.261  1.00 83.93  ? 413  VAL   A CA  1 
ATOM   3262 C  C   . VAL   A 1 412 ? -25.852 -115.347 0.988   1.00 81.57  ? 413  VAL   A C   1 
ATOM   3263 O  O   . VAL   A 1 412 ? -26.381 -115.203 2.109   1.00 78.98  ? 413  VAL   A O   1 
ATOM   3264 C  CB  . VAL   A 1 412 ? -27.374 -113.830 -0.354  1.00 84.45  ? 413  VAL   A CB  1 
ATOM   3265 C  CG1 . VAL   A 1 412 ? -26.315 -112.740 -0.434  1.00 85.13  ? 413  VAL   A CG1 1 
ATOM   3266 C  CG2 . VAL   A 1 412 ? -28.336 -113.722 -1.527  1.00 86.27  ? 413  VAL   A CG2 1 
ATOM   3267 N  N   . THR   A 1 413 ? -24.556 -115.600 0.782   1.00 76.81  ? 414  THR   A N   1 
ATOM   3268 C  CA  . THR   A 1 413 ? -23.471 -115.437 1.784   1.00 76.36  ? 414  THR   A CA  1 
ATOM   3269 C  C   . THR   A 1 413 ? -22.877 -114.031 1.632   1.00 75.20  ? 414  THR   A C   1 
ATOM   3270 O  O   . THR   A 1 413 ? -22.214 -113.789 0.603   1.00 74.50  ? 414  THR   A O   1 
ATOM   3271 C  CB  . THR   A 1 413 ? -22.379 -116.496 1.585   1.00 77.51  ? 414  THR   A CB  1 
ATOM   3272 O  OG1 . THR   A 1 413 ? -23.012 -117.777 1.571   1.00 77.86  ? 414  THR   A OG1 1 
ATOM   3273 C  CG2 . THR   A 1 413 ? -21.294 -116.440 2.641   1.00 75.88  ? 414  THR   A CG2 1 
ATOM   3274 N  N   . VAL   A 1 414 ? -23.101 -113.140 2.605   1.00 72.19  ? 415  VAL   A N   1 
ATOM   3275 C  CA  . VAL   A 1 414 ? -22.481 -111.780 2.628   1.00 65.84  ? 415  VAL   A CA  1 
ATOM   3276 C  C   . VAL   A 1 414 ? -21.048 -111.914 3.150   1.00 64.21  ? 415  VAL   A C   1 
ATOM   3277 O  O   . VAL   A 1 414 ? -20.855 -112.560 4.198   1.00 66.80  ? 415  VAL   A O   1 
ATOM   3278 C  CB  . VAL   A 1 414 ? -23.286 -110.772 3.469   1.00 64.20  ? 415  VAL   A CB  1 
ATOM   3279 C  CG1 . VAL   A 1 414 ? -22.629 -109.402 3.456   1.00 67.85  ? 415  VAL   A CG1 1 
ATOM   3280 C  CG2 . VAL   A 1 414 ? -24.730 -110.664 3.006   1.00 64.79  ? 415  VAL   A CG2 1 
ATOM   3281 N  N   . VAL   A 1 415 ? -20.084 -111.339 2.430   1.00 64.28  ? 416  VAL   A N   1 
ATOM   3282 C  CA  . VAL   A 1 415 ? -18.653 -111.269 2.842   1.00 65.17  ? 416  VAL   A CA  1 
ATOM   3283 C  C   . VAL   A 1 415 ? -18.291 -109.795 3.028   1.00 65.24  ? 416  VAL   A C   1 
ATOM   3284 O  O   . VAL   A 1 415 ? -18.392 -109.037 2.053   1.00 65.96  ? 416  VAL   A O   1 
ATOM   3285 C  CB  . VAL   A 1 415 ? -17.732 -111.955 1.818   1.00 68.06  ? 416  VAL   A CB  1 
ATOM   3286 C  CG1 . VAL   A 1 415 ? -16.263 -111.776 2.171   1.00 67.33  ? 416  VAL   A CG1 1 
ATOM   3287 C  CG2 . VAL   A 1 415 ? -18.072 -113.431 1.666   1.00 69.06  ? 416  VAL   A CG2 1 
ATOM   3288 N  N   . SER   A 1 416 ? -17.906 -109.416 4.247   1.00 67.06  ? 417  SER   A N   1 
ATOM   3289 C  CA  . SER   A 1 416 ? -17.406 -108.064 4.603   1.00 64.27  ? 417  SER   A CA  1 
ATOM   3290 C  C   . SER   A 1 416 ? -15.897 -108.037 4.374   1.00 63.22  ? 417  SER   A C   1 
ATOM   3291 O  O   . SER   A 1 416 ? -15.155 -108.299 5.339   1.00 62.97  ? 417  SER   A O   1 
ATOM   3292 C  CB  . SER   A 1 416 ? -17.752 -107.711 6.019   1.00 62.96  ? 417  SER   A CB  1 
ATOM   3293 O  OG  . SER   A 1 416 ? -17.441 -106.354 6.279   1.00 66.46  ? 417  SER   A OG  1 
ATOM   3294 N  N   . SER   A 1 417 ? -15.463 -107.764 3.142   1.00 62.33  ? 418  SER   A N   1 
ATOM   3295 C  CA  . SER   A 1 417 ? -14.044 -107.919 2.732   1.00 64.38  ? 418  SER   A CA  1 
ATOM   3296 C  C   . SER   A 1 417 ? -13.728 -107.146 1.445   1.00 64.55  ? 418  SER   A C   1 
ATOM   3297 O  O   . SER   A 1 417 ? -14.625 -106.986 0.590   1.00 62.31  ? 418  SER   A O   1 
ATOM   3298 C  CB  . SER   A 1 417 ? -13.710 -109.379 2.580   1.00 63.89  ? 418  SER   A CB  1 
ATOM   3299 O  OG  . SER   A 1 417 ? -12.308 -109.575 2.506   1.00 66.41  ? 418  SER   A OG  1 
ATOM   3300 N  N   . ASP   A 1 418 ? -12.482 -106.678 1.339   1.00 61.69  ? 419  ASP   A N   1 
ATOM   3301 C  CA  . ASP   A 1 418 ? -11.845 -106.245 0.072   1.00 61.65  ? 419  ASP   A CA  1 
ATOM   3302 C  C   . ASP   A 1 418 ? -11.734 -107.494 -0.806  1.00 62.24  ? 419  ASP   A C   1 
ATOM   3303 O  O   . ASP   A 1 418 ? -11.312 -108.536 -0.278  1.00 65.81  ? 419  ASP   A O   1 
ATOM   3304 C  CB  . ASP   A 1 418 ? -10.487 -105.586 0.336   1.00 61.96  ? 419  ASP   A CB  1 
ATOM   3305 C  CG  . ASP   A 1 418 ? -9.972  -104.733 -0.811  1.00 63.55  ? 419  ASP   A CG  1 
ATOM   3306 O  OD1 . ASP   A 1 418 ? -9.877  -105.257 -1.940  1.00 61.82  ? 419  ASP   A OD1 1 
ATOM   3307 O  OD2 . ASP   A 1 418 ? -9.676  -103.546 -0.566  1.00 67.38  ? 419  ASP   A OD2 1 
ATOM   3308 N  N   . MET   A 1 419 ? -12.113 -107.402 -2.083  1.00 59.78  ? 420  MET   A N   1 
ATOM   3309 C  CA  . MET   A 1 419 ? -12.112 -108.560 -3.013  1.00 58.50  ? 420  MET   A CA  1 
ATOM   3310 C  C   . MET   A 1 419 ? -10.669 -108.992 -3.311  1.00 59.78  ? 420  MET   A C   1 
ATOM   3311 O  O   . MET   A 1 419 ? -10.487 -110.136 -3.761  1.00 62.18  ? 420  MET   A O   1 
ATOM   3312 C  CB  . MET   A 1 419 ? -12.859 -108.242 -4.313  1.00 58.31  ? 420  MET   A CB  1 
ATOM   3313 C  CG  . MET   A 1 419 ? -12.252 -107.124 -5.143  1.00 58.50  ? 420  MET   A CG  1 
ATOM   3314 S  SD  . MET   A 1 419 ? -13.229 -106.789 -6.633  1.00 59.40  ? 420  MET   A SD  1 
ATOM   3315 C  CE  . MET   A 1 419 ? -14.636 -105.929 -5.927  1.00 56.45  ? 420  MET   A CE  1 
ATOM   3316 N  N   . ARG   A 1 420 ? -9.686  -108.124 -3.050  1.00 60.19  ? 421  ARG   A N   1 
ATOM   3317 C  CA  . ARG   A 1 420 ? -8.240  -108.398 -3.276  1.00 63.79  ? 421  ARG   A CA  1 
ATOM   3318 C  C   . ARG   A 1 420 ? -7.674  -109.219 -2.109  1.00 71.10  ? 421  ARG   A C   1 
ATOM   3319 O  O   . ARG   A 1 420 ? -6.726  -109.993 -2.344  1.00 75.48  ? 421  ARG   A O   1 
ATOM   3320 C  CB  . ARG   A 1 420 ? -7.468  -107.085 -3.446  1.00 62.64  ? 421  ARG   A CB  1 
ATOM   3321 C  CG  . ARG   A 1 420 ? -7.877  -106.276 -4.670  1.00 63.43  ? 421  ARG   A CG  1 
ATOM   3322 C  CD  . ARG   A 1 420 ? -7.229  -104.904 -4.731  1.00 62.41  ? 421  ARG   A CD  1 
ATOM   3323 N  NE  . ARG   A 1 420 ? -7.693  -104.044 -3.649  1.00 62.32  ? 421  ARG   A NE  1 
ATOM   3324 C  CZ  . ARG   A 1 420 ? -7.127  -102.894 -3.282  1.00 61.29  ? 421  ARG   A CZ  1 
ATOM   3325 N  NH1 . ARG   A 1 420 ? -6.062  -102.429 -3.917  1.00 58.81  ? 421  ARG   A NH1 1 
ATOM   3326 N  NH2 . ARG   A 1 420 ? -7.633  -102.212 -2.268  1.00 60.50  ? 421  ARG   A NH2 1 
ATOM   3327 N  N   . GLU   A 1 421 ? -8.229  -109.058 -0.902  1.00 78.80  ? 422  GLU   A N   1 
ATOM   3328 C  CA  . GLU   A 1 421 ? -7.753  -109.732 0.339   1.00 85.10  ? 422  GLU   A CA  1 
ATOM   3329 C  C   . GLU   A 1 421 ? -8.516  -111.046 0.568   1.00 82.08  ? 422  GLU   A C   1 
ATOM   3330 O  O   . GLU   A 1 421 ? -7.912  -111.980 1.132   1.00 83.15  ? 422  GLU   A O   1 
ATOM   3331 C  CB  . GLU   A 1 421 ? -7.921  -108.811 1.551   1.00 90.92  ? 422  GLU   A CB  1 
ATOM   3332 C  CG  . GLU   A 1 421 ? -7.161  -107.500 1.445   1.00 97.99  ? 422  GLU   A CG  1 
ATOM   3333 C  CD  . GLU   A 1 421 ? -5.656  -107.597 1.639   1.00 106.77 ? 422  GLU   A CD  1 
ATOM   3334 O  OE1 . GLU   A 1 421 ? -5.135  -106.891 2.528   1.00 114.62 ? 422  GLU   A OE1 1 
ATOM   3335 O  OE2 . GLU   A 1 421 ? -5.006  -108.363 0.895   1.00 111.53 ? 422  GLU   A OE2 1 
ATOM   3336 N  N   . TRP   A 1 422 ? -9.786  -111.114 0.156   1.00 77.56  ? 423  TRP   A N   1 
ATOM   3337 C  CA  . TRP   A 1 422 ? -10.714 -112.237 0.460   1.00 80.34  ? 423  TRP   A CA  1 
ATOM   3338 C  C   . TRP   A 1 422 ? -10.132 -113.574 -0.016  1.00 81.47  ? 423  TRP   A C   1 
ATOM   3339 O  O   . TRP   A 1 422 ? -9.770  -113.676 -1.206  1.00 79.21  ? 423  TRP   A O   1 
ATOM   3340 C  CB  . TRP   A 1 422 ? -12.092 -111.985 -0.161  1.00 80.44  ? 423  TRP   A CB  1 
ATOM   3341 C  CG  . TRP   A 1 422 ? -13.115 -113.022 0.190   1.00 80.98  ? 423  TRP   A CG  1 
ATOM   3342 C  CD1 . TRP   A 1 422 ? -13.336 -113.579 1.416   1.00 80.41  ? 423  TRP   A CD1 1 
ATOM   3343 C  CD2 . TRP   A 1 422 ? -14.081 -113.611 -0.698  1.00 81.73  ? 423  TRP   A CD2 1 
ATOM   3344 N  NE1 . TRP   A 1 422 ? -14.367 -114.477 1.351   1.00 82.50  ? 423  TRP   A NE1 1 
ATOM   3345 C  CE2 . TRP   A 1 422 ? -14.844 -114.519 0.067   1.00 81.53  ? 423  TRP   A CE2 1 
ATOM   3346 C  CE3 . TRP   A 1 422 ? -14.371 -113.465 -2.059  1.00 81.14  ? 423  TRP   A CE3 1 
ATOM   3347 C  CZ2 . TRP   A 1 422 ? -15.874 -115.276 -0.489  1.00 83.05  ? 423  TRP   A CZ2 1 
ATOM   3348 C  CZ3 . TRP   A 1 422 ? -15.390 -114.212 -2.608  1.00 81.28  ? 423  TRP   A CZ3 1 
ATOM   3349 C  CH2 . TRP   A 1 422 ? -16.131 -115.104 -1.831  1.00 83.50  ? 423  TRP   A CH2 1 
ATOM   3350 N  N   . VAL   A 1 423 ? -10.053 -114.551 0.894   1.00 83.94  ? 424  VAL   A N   1 
ATOM   3351 C  CA  . VAL   A 1 423 ? -9.829  -115.992 0.577   1.00 84.13  ? 424  VAL   A CA  1 
ATOM   3352 C  C   . VAL   A 1 423 ? -11.205 -116.624 0.354   1.00 82.61  ? 424  VAL   A C   1 
ATOM   3353 O  O   . VAL   A 1 423 ? -12.027 -116.587 1.285   1.00 76.20  ? 424  VAL   A O   1 
ATOM   3354 C  CB  . VAL   A 1 423 ? -9.053  -116.718 1.692   1.00 86.41  ? 424  VAL   A CB  1 
ATOM   3355 C  CG1 . VAL   A 1 423 ? -8.737  -118.155 1.304   1.00 89.30  ? 424  VAL   A CG1 1 
ATOM   3356 C  CG2 . VAL   A 1 423 ? -7.780  -115.977 2.072   1.00 88.58  ? 424  VAL   A CG2 1 
ATOM   3357 N  N   . ALA   A 1 424 ? -11.448 -117.151 -0.847  1.00 85.47  ? 425  ALA   A N   1 
ATOM   3358 C  CA  . ALA   A 1 424 ? -12.742 -117.741 -1.255  1.00 87.82  ? 425  ALA   A CA  1 
ATOM   3359 C  C   . ALA   A 1 424 ? -12.803 -119.192 -0.788  1.00 87.90  ? 425  ALA   A C   1 
ATOM   3360 O  O   . ALA   A 1 424 ? -11.809 -119.910 -0.881  1.00 86.64  ? 425  ALA   A O   1 
ATOM   3361 C  CB  . ALA   A 1 424 ? -12.906 -117.634 -2.749  1.00 90.11  ? 425  ALA   A CB  1 
ATOM   3362 N  N   . PRO   A 1 425 ? -13.954 -119.666 -0.257  1.00 92.73  ? 426  PRO   A N   1 
ATOM   3363 C  CA  . PRO   A 1 425 ? -14.135 -121.091 0.024   1.00 96.29  ? 426  PRO   A CA  1 
ATOM   3364 C  C   . PRO   A 1 425 ? -14.085 -121.942 -1.258  1.00 95.93  ? 426  PRO   A C   1 
ATOM   3365 O  O   . PRO   A 1 425 ? -13.511 -123.015 -1.222  1.00 94.49  ? 426  PRO   A O   1 
ATOM   3366 C  CB  . PRO   A 1 425 ? -15.515 -121.168 0.703   1.00 98.17  ? 426  PRO   A CB  1 
ATOM   3367 C  CG  . PRO   A 1 425 ? -16.227 -119.902 0.268   1.00 96.27  ? 426  PRO   A CG  1 
ATOM   3368 C  CD  . PRO   A 1 425 ? -15.133 -118.867 0.117   1.00 94.54  ? 426  PRO   A CD  1 
ATOM   3369 N  N   . GLU   A 1 426 ? -14.662 -121.431 -2.353  1.00 93.89  ? 427  GLU   A N   1 
ATOM   3370 C  CA  . GLU   A 1 426 ? -14.771 -122.120 -3.669  1.00 87.39  ? 427  GLU   A CA  1 
ATOM   3371 C  C   . GLU   A 1 426 ? -14.607 -121.096 -4.798  1.00 87.21  ? 427  GLU   A C   1 
ATOM   3372 O  O   . GLU   A 1 426 ? -15.040 -119.936 -4.609  1.00 89.57  ? 427  GLU   A O   1 
ATOM   3373 C  CB  . GLU   A 1 426 ? -16.128 -122.816 -3.788  1.00 83.44  ? 427  GLU   A CB  1 
ATOM   3374 C  CG  . GLU   A 1 426 ? -17.295 -121.925 -3.397  1.00 79.78  ? 427  GLU   A CG  1 
ATOM   3375 C  CD  . GLU   A 1 426 ? -18.668 -122.530 -3.617  1.00 77.89  ? 427  GLU   A CD  1 
ATOM   3376 O  OE1 . GLU   A 1 426 ? -19.587 -122.178 -2.862  1.00 76.80  ? 427  GLU   A OE1 1 
ATOM   3377 O  OE2 . GLU   A 1 426 ? -18.816 -123.345 -4.543  1.00 81.56  ? 427  GLU   A OE2 1 
ATOM   3378 N  N   . LYS   A 1 427 ? -14.030 -121.515 -5.930  1.00 82.15  ? 428  LYS   A N   1 
ATOM   3379 C  CA  . LYS   A 1 427 ? -13.853 -120.661 -7.136  1.00 78.14  ? 428  LYS   A CA  1 
ATOM   3380 C  C   . LYS   A 1 427 ? -15.230 -120.365 -7.744  1.00 74.96  ? 428  LYS   A C   1 
ATOM   3381 O  O   . LYS   A 1 427 ? -16.204 -121.064 -7.388  1.00 70.29  ? 428  LYS   A O   1 
ATOM   3382 C  CB  . LYS   A 1 427 ? -12.897 -121.321 -8.135  1.00 79.63  ? 428  LYS   A CB  1 
ATOM   3383 C  CG  . LYS   A 1 427 ? -11.461 -121.441 -7.641  1.00 83.09  ? 428  LYS   A CG  1 
ATOM   3384 C  CD  . LYS   A 1 427 ? -10.444 -121.751 -8.721  1.00 84.52  ? 428  LYS   A CD  1 
ATOM   3385 C  CE  . LYS   A 1 427 ? -9.034  -121.843 -8.175  1.00 89.76  ? 428  LYS   A CE  1 
ATOM   3386 N  NZ  . LYS   A 1 427 ? -8.033  -122.059 -9.248  1.00 92.36  ? 428  LYS   A NZ  1 
ATOM   3387 N  N   . ALA   A 1 428 ? -15.305 -119.348 -8.607  1.00 73.79  ? 429  ALA   A N   1 
ATOM   3388 C  CA  . ALA   A 1 428 ? -16.564 -118.800 -9.164  1.00 74.23  ? 429  ALA   A CA  1 
ATOM   3389 C  C   . ALA   A 1 428 ? -16.683 -119.132 -10.653 1.00 72.57  ? 429  ALA   A C   1 
ATOM   3390 O  O   . ALA   A 1 428 ? -15.637 -119.243 -11.329 1.00 68.71  ? 429  ALA   A O   1 
ATOM   3391 C  CB  . ALA   A 1 428 ? -16.621 -117.311 -8.940  1.00 75.78  ? 429  ALA   A CB  1 
ATOM   3392 N  N   . ASP   A 1 429 ? -17.926 -119.259 -11.126 1.00 73.73  ? 430  ASP   A N   1 
ATOM   3393 C  CA  . ASP   A 1 429 ? -18.288 -119.436 -12.557 1.00 78.25  ? 430  ASP   A CA  1 
ATOM   3394 C  C   . ASP   A 1 429 ? -18.477 -118.052 -13.192 1.00 77.29  ? 430  ASP   A C   1 
ATOM   3395 O  O   . ASP   A 1 429 ? -18.000 -117.856 -14.332 1.00 73.15  ? 430  ASP   A O   1 
ATOM   3396 C  CB  . ASP   A 1 429 ? -19.536 -120.313 -12.694 1.00 82.35  ? 430  ASP   A CB  1 
ATOM   3397 C  CG  . ASP   A 1 429 ? -19.308 -121.754 -12.263 1.00 86.33  ? 430  ASP   A CG  1 
ATOM   3398 O  OD1 . ASP   A 1 429 ? -18.563 -122.462 -12.972 1.00 84.07  ? 430  ASP   A OD1 1 
ATOM   3399 O  OD2 . ASP   A 1 429 ? -19.857 -122.152 -11.209 1.00 84.42  ? 430  ASP   A OD2 1 
ATOM   3400 N  N   . ILE   A 1 430 ? -19.152 -117.141 -12.476 1.00 74.49  ? 431  ILE   A N   1 
ATOM   3401 C  CA  . ILE   A 1 430 ? -19.365 -115.716 -12.875 1.00 72.04  ? 431  ILE   A CA  1 
ATOM   3402 C  C   . ILE   A 1 430 ? -18.994 -114.805 -11.698 1.00 72.59  ? 431  ILE   A C   1 
ATOM   3403 O  O   . ILE   A 1 430 ? -19.564 -114.989 -10.602 1.00 70.60  ? 431  ILE   A O   1 
ATOM   3404 C  CB  . ILE   A 1 430 ? -20.819 -115.449 -13.320 1.00 74.07  ? 431  ILE   A CB  1 
ATOM   3405 C  CG1 . ILE   A 1 430 ? -21.383 -116.551 -14.222 1.00 73.88  ? 431  ILE   A CG1 1 
ATOM   3406 C  CG2 . ILE   A 1 430 ? -20.926 -114.078 -13.980 1.00 73.11  ? 431  ILE   A CG2 1 
ATOM   3407 C  CD1 . ILE   A 1 430 ? -22.896 -116.543 -14.310 1.00 74.10  ? 431  ILE   A CD1 1 
ATOM   3408 N  N   . ILE   A 1 431 ? -18.095 -113.843 -11.933 1.00 70.76  ? 432  ILE   A N   1 
ATOM   3409 C  CA  . ILE   A 1 431 ? -17.895 -112.642 -11.067 1.00 63.92  ? 432  ILE   A CA  1 
ATOM   3410 C  C   . ILE   A 1 431 ? -18.667 -111.484 -11.705 1.00 63.46  ? 432  ILE   A C   1 
ATOM   3411 O  O   . ILE   A 1 431 ? -18.522 -111.279 -12.923 1.00 66.31  ? 432  ILE   A O   1 
ATOM   3412 C  CB  . ILE   A 1 431 ? -16.402 -112.311 -10.863 1.00 64.99  ? 432  ILE   A CB  1 
ATOM   3413 C  CG1 . ILE   A 1 431 ? -15.653 -112.116 -12.185 1.00 65.03  ? 432  ILE   A CG1 1 
ATOM   3414 C  CG2 . ILE   A 1 431 ? -15.745 -113.362 -9.981  1.00 67.89  ? 432  ILE   A CG2 1 
ATOM   3415 C  CD1 . ILE   A 1 431 ? -14.181 -111.809 -12.029 1.00 67.51  ? 432  ILE   A CD1 1 
ATOM   3416 N  N   . VAL   A 1 432 ? -19.480 -110.780 -10.916 1.00 63.25  ? 433  VAL   A N   1 
ATOM   3417 C  CA  . VAL   A 1 432 ? -20.296 -109.612 -11.361 1.00 66.03  ? 433  VAL   A CA  1 
ATOM   3418 C  C   . VAL   A 1 432 ? -19.825 -108.373 -10.587 1.00 67.99  ? 433  VAL   A C   1 
ATOM   3419 O  O   . VAL   A 1 432 ? -19.857 -108.420 -9.344  1.00 69.31  ? 433  VAL   A O   1 
ATOM   3420 C  CB  . VAL   A 1 432 ? -21.794 -109.893 -11.145 1.00 66.30  ? 433  VAL   A CB  1 
ATOM   3421 C  CG1 . VAL   A 1 432 ? -22.651 -108.649 -11.325 1.00 66.09  ? 433  VAL   A CG1 1 
ATOM   3422 C  CG2 . VAL   A 1 432 ? -22.277 -111.015 -12.049 1.00 68.66  ? 433  VAL   A CG2 1 
ATOM   3423 N  N   . SER   A 1 433 ? -19.400 -107.310 -11.282 1.00 67.81  ? 434  SER   A N   1 
ATOM   3424 C  CA  . SER   A 1 433 ? -18.859 -106.076 -10.650 1.00 64.82  ? 434  SER   A CA  1 
ATOM   3425 C  C   . SER   A 1 433 ? -19.452 -104.814 -11.281 1.00 62.52  ? 434  SER   A C   1 
ATOM   3426 O  O   . SER   A 1 433 ? -19.825 -104.843 -12.465 1.00 66.34  ? 434  SER   A O   1 
ATOM   3427 C  CB  . SER   A 1 433 ? -17.356 -106.049 -10.684 1.00 63.91  ? 434  SER   A CB  1 
ATOM   3428 O  OG  . SER   A 1 433 ? -16.877 -105.908 -12.010 1.00 64.41  ? 434  SER   A OG  1 
ATOM   3429 N  N   . GLU   A 1 434 ? -19.481 -103.746 -10.483 1.00 62.83  ? 435  GLU   A N   1 
ATOM   3430 C  CA  . GLU   A 1 434 ? -20.143 -102.441 -10.743 1.00 60.03  ? 435  GLU   A CA  1 
ATOM   3431 C  C   . GLU   A 1 434 ? -19.136 -101.337 -10.372 1.00 58.32  ? 435  GLU   A C   1 
ATOM   3432 O  O   . GLU   A 1 434 ? -19.529 -100.356 -9.713  1.00 55.70  ? 435  GLU   A O   1 
ATOM   3433 C  CB  . GLU   A 1 434 ? -21.439 -102.431 -9.923  1.00 60.23  ? 435  GLU   A CB  1 
ATOM   3434 C  CG  . GLU   A 1 434 ? -22.338 -101.226 -10.125 1.00 59.76  ? 435  GLU   A CG  1 
ATOM   3435 C  CD  . GLU   A 1 434 ? -23.580 -101.164 -9.244  1.00 60.40  ? 435  GLU   A CD  1 
ATOM   3436 O  OE1 . GLU   A 1 434 ? -23.761 -102.048 -8.379  1.00 55.02  ? 435  GLU   A OE1 1 
ATOM   3437 O  OE2 . GLU   A 1 434 ? -24.377 -100.224 -9.429  1.00 63.82  ? 435  GLU   A OE2 1 
ATOM   3438 N  N   . LEU   A 1 435 ? -17.871 -101.502 -10.776 1.00 54.34  ? 436  LEU   A N   1 
ATOM   3439 C  CA  . LEU   A 1 435 ? -16.721 -100.711 -10.261 1.00 57.53  ? 436  LEU   A CA  1 
ATOM   3440 C  C   . LEU   A 1 435 ? -16.271 -99.650  -11.268 1.00 57.61  ? 436  LEU   A C   1 
ATOM   3441 O  O   . LEU   A 1 435 ? -15.123 -99.185  -11.141 1.00 59.64  ? 436  LEU   A O   1 
ATOM   3442 C  CB  . LEU   A 1 435 ? -15.561 -101.664 -9.967  1.00 58.38  ? 436  LEU   A CB  1 
ATOM   3443 C  CG  . LEU   A 1 435 ? -15.932 -102.904 -9.164  1.00 58.78  ? 436  LEU   A CG  1 
ATOM   3444 C  CD1 . LEU   A 1 435 ? -14.745 -103.850 -9.063  1.00 58.21  ? 436  LEU   A CD1 1 
ATOM   3445 C  CD2 . LEU   A 1 435 ? -16.450 -102.517 -7.785  1.00 61.08  ? 436  LEU   A CD2 1 
ATOM   3446 N  N   . LEU   A 1 436 ? -17.121 -99.289  -12.230 1.00 60.24  ? 437  LEU   A N   1 
ATOM   3447 C  CA  . LEU   A 1 436 ? -16.755 -98.343  -13.313 1.00 59.18  ? 437  LEU   A CA  1 
ATOM   3448 C  C   . LEU   A 1 436 ? -17.078 -96.917  -12.864 1.00 59.01  ? 437  LEU   A C   1 
ATOM   3449 O  O   . LEU   A 1 436 ? -18.024 -96.729  -12.072 1.00 58.84  ? 437  LEU   A O   1 
ATOM   3450 C  CB  . LEU   A 1 436 ? -17.492 -98.705  -14.608 1.00 61.38  ? 437  LEU   A CB  1 
ATOM   3451 C  CG  . LEU   A 1 436 ? -17.048 -99.998  -15.294 1.00 62.35  ? 437  LEU   A CG  1 
ATOM   3452 C  CD1 . LEU   A 1 436 ? -17.293 -99.921  -16.794 1.00 62.83  ? 437  LEU   A CD1 1 
ATOM   3453 C  CD2 . LEU   A 1 436 ? -15.584 -100.311 -15.016 1.00 60.51  ? 437  LEU   A CD2 1 
ATOM   3454 N  N   . GLY   A 1 437 ? -16.269 -95.966  -13.333 1.00 59.37  ? 438  GLY   A N   1 
ATOM   3455 C  CA  . GLY   A 1 437 ? -16.511 -94.516  -13.227 1.00 56.14  ? 438  GLY   A CA  1 
ATOM   3456 C  C   . GLY   A 1 437 ? -16.747 -93.919  -14.601 1.00 53.47  ? 438  GLY   A C   1 
ATOM   3457 O  O   . GLY   A 1 437 ? -16.742 -94.676  -15.585 1.00 52.03  ? 438  GLY   A O   1 
ATOM   3458 N  N   . SER   A 1 438 ? -16.929 -92.603  -14.676 1.00 53.42  ? 439  SER   A N   1 
ATOM   3459 C  CA  . SER   A 1 438 ? -17.238 -91.876  -15.936 1.00 54.51  ? 439  SER   A CA  1 
ATOM   3460 C  C   . SER   A 1 438 ? -16.100 -92.030  -16.956 1.00 53.51  ? 439  SER   A C   1 
ATOM   3461 O  O   . SER   A 1 438 ? -16.394 -91.959  -18.163 1.00 54.61  ? 439  SER   A O   1 
ATOM   3462 C  CB  . SER   A 1 438 ? -17.566 -90.440  -15.655 1.00 55.25  ? 439  SER   A CB  1 
ATOM   3463 O  OG  . SER   A 1 438 ? -18.891 -90.329  -15.150 1.00 55.56  ? 439  SER   A OG  1 
ATOM   3464 N  N   . PHE   A 1 439 ? -14.858 -92.243  -16.509 1.00 52.23  ? 440  PHE   A N   1 
ATOM   3465 C  CA  . PHE   A 1 439 ? -13.697 -92.520  -17.399 1.00 53.06  ? 440  PHE   A CA  1 
ATOM   3466 C  C   . PHE   A 1 439 ? -13.356 -94.014  -17.341 1.00 52.84  ? 440  PHE   A C   1 
ATOM   3467 O  O   . PHE   A 1 439 ? -12.186 -94.386  -17.585 1.00 53.37  ? 440  PHE   A O   1 
ATOM   3468 C  CB  . PHE   A 1 439 ? -12.506 -91.636  -17.021 1.00 50.90  ? 440  PHE   A CB  1 
ATOM   3469 C  CG  . PHE   A 1 439 ? -11.586 -91.322  -18.171 1.00 49.74  ? 440  PHE   A CG  1 
ATOM   3470 C  CD1 . PHE   A 1 439 ? -12.094 -90.893  -19.385 1.00 49.80  ? 440  PHE   A CD1 1 
ATOM   3471 C  CD2 . PHE   A 1 439 ? -10.212 -91.430  -18.034 1.00 49.97  ? 440  PHE   A CD2 1 
ATOM   3472 C  CE1 . PHE   A 1 439 ? -11.248 -90.602  -20.440 1.00 50.53  ? 440  PHE   A CE1 1 
ATOM   3473 C  CE2 . PHE   A 1 439 ? -9.367  -91.129  -19.089 1.00 48.07  ? 440  PHE   A CE2 1 
ATOM   3474 C  CZ  . PHE   A 1 439 ? -9.887  -90.721  -20.290 1.00 48.67  ? 440  PHE   A CZ  1 
ATOM   3475 N  N   . ALA   A 1 440 ? -14.364 -94.831  -17.018 1.00 51.93  ? 441  ALA   A N   1 
ATOM   3476 C  CA  . ALA   A 1 440 ? -14.315 -96.310  -16.925 1.00 51.71  ? 441  ALA   A CA  1 
ATOM   3477 C  C   . ALA   A 1 440 ? -13.398 -96.755  -15.782 1.00 50.94  ? 441  ALA   A C   1 
ATOM   3478 O  O   . ALA   A 1 440 ? -13.918 -97.097  -14.710 1.00 49.83  ? 441  ALA   A O   1 
ATOM   3479 C  CB  . ALA   A 1 440 ? -13.881 -96.902  -18.244 1.00 52.53  ? 441  ALA   A CB  1 
ATOM   3480 N  N   . ASP   A 1 441 ? -12.083 -96.734  -16.003 1.00 53.02  ? 442  ASP   A N   1 
ATOM   3481 C  CA  . ASP   A 1 441 ? -11.081 -97.369  -15.107 1.00 51.56  ? 442  ASP   A CA  1 
ATOM   3482 C  C   . ASP   A 1 441 ? -10.680 -96.421  -13.967 1.00 51.60  ? 442  ASP   A C   1 
ATOM   3483 O  O   . ASP   A 1 441 ? -9.751  -96.785  -13.224 1.00 53.10  ? 442  ASP   A O   1 
ATOM   3484 C  CB  . ASP   A 1 441 ? -9.855  -97.817  -15.905 1.00 51.10  ? 442  ASP   A CB  1 
ATOM   3485 C  CG  . ASP   A 1 441 ? -9.213  -96.704  -16.703 1.00 49.92  ? 442  ASP   A CG  1 
ATOM   3486 O  OD1 . ASP   A 1 441 ? -9.661  -96.469  -17.835 1.00 52.95  ? 442  ASP   A OD1 1 
ATOM   3487 O  OD2 . ASP   A 1 441 ? -8.286  -96.073  -16.170 1.00 53.67  ? 442  ASP   A OD2 1 
ATOM   3488 N  N   . ASN   A 1 442 ? -11.345 -95.269  -13.813 1.00 49.77  ? 443  ASN   A N   1 
ATOM   3489 C  CA  . ASN   A 1 442 ? -10.909 -94.193  -12.880 1.00 49.79  ? 443  ASN   A CA  1 
ATOM   3490 C  C   . ASN   A 1 442 ? -11.256 -94.546  -11.426 1.00 47.49  ? 443  ASN   A C   1 
ATOM   3491 O  O   . ASN   A 1 442 ? -10.728 -93.865  -10.538 1.00 48.89  ? 443  ASN   A O   1 
ATOM   3492 C  CB  . ASN   A 1 442 ? -11.470 -92.818  -13.259 1.00 51.27  ? 443  ASN   A CB  1 
ATOM   3493 C  CG  . ASN   A 1 442 ? -12.974 -92.809  -13.409 1.00 53.01  ? 443  ASN   A CG  1 
ATOM   3494 O  OD1 . ASN   A 1 442 ? -13.501 -93.422  -14.332 1.00 55.00  ? 443  ASN   A OD1 1 
ATOM   3495 N  ND2 . ASN   A 1 442 ? -13.667 -92.111  -12.523 1.00 55.00  ? 443  ASN   A ND2 1 
ATOM   3496 N  N   . GLU   A 1 443 ? -12.097 -95.555  -11.178 1.00 48.73  ? 444  GLU   A N   1 
ATOM   3497 C  CA  . GLU   A 1 443 ? -12.398 -96.054  -9.803  1.00 48.23  ? 444  GLU   A CA  1 
ATOM   3498 C  C   . GLU   A 1 443 ? -11.531 -97.289  -9.504  1.00 49.00  ? 444  GLU   A C   1 
ATOM   3499 O  O   . GLU   A 1 443 ? -11.622 -97.806  -8.379  1.00 51.80  ? 444  GLU   A O   1 
ATOM   3500 C  CB  . GLU   A 1 443 ? -13.898 -96.325  -9.640  1.00 47.76  ? 444  GLU   A CB  1 
ATOM   3501 C  CG  . GLU   A 1 443 ? -14.740 -95.059  -9.612  1.00 48.86  ? 444  GLU   A CG  1 
ATOM   3502 C  CD  . GLU   A 1 443 ? -16.231 -95.259  -9.397  1.00 49.22  ? 444  GLU   A CD  1 
ATOM   3503 O  OE1 . GLU   A 1 443 ? -16.638 -96.387  -9.057  1.00 52.92  ? 444  GLU   A OE1 1 
ATOM   3504 O  OE2 . GLU   A 1 443 ? -16.985 -94.283  -9.569  1.00 50.85  ? 444  GLU   A OE2 1 
ATOM   3505 N  N   . LEU   A 1 444 ? -10.713 -97.725  -10.469 1.00 49.87  ? 445  LEU   A N   1 
ATOM   3506 C  CA  . LEU   A 1 444 ? -9.669  -98.782  -10.338 1.00 53.92  ? 445  LEU   A CA  1 
ATOM   3507 C  C   . LEU   A 1 444 ? -10.300 -100.179 -10.397 1.00 56.96  ? 445  LEU   A C   1 
ATOM   3508 O  O   . LEU   A 1 444 ? -9.790  -101.085 -9.702  1.00 57.20  ? 445  LEU   A O   1 
ATOM   3509 C  CB  . LEU   A 1 444 ? -8.872  -98.601  -9.040  1.00 54.87  ? 445  LEU   A CB  1 
ATOM   3510 C  CG  . LEU   A 1 444 ? -8.294  -97.208  -8.794  1.00 55.33  ? 445  LEU   A CG  1 
ATOM   3511 C  CD1 . LEU   A 1 444 ? -7.167  -97.277  -7.777  1.00 55.23  ? 445  LEU   A CD1 1 
ATOM   3512 C  CD2 . LEU   A 1 444 ? -7.806  -96.570  -10.088 1.00 54.85  ? 445  LEU   A CD2 1 
ATOM   3513 N  N   . SER   A 1 445 ? -11.328 -100.356 -11.235 1.00 59.37  ? 446  SER   A N   1 
ATOM   3514 C  CA  . SER   A 1 445 ? -11.885 -101.677 -11.628 1.00 58.87  ? 446  SER   A CA  1 
ATOM   3515 C  C   . SER   A 1 445 ? -10.752 -102.624 -12.028 1.00 56.20  ? 446  SER   A C   1 
ATOM   3516 O  O   . SER   A 1 445 ? -10.658 -103.715 -11.478 1.00 57.89  ? 446  SER   A O   1 
ATOM   3517 C  CB  . SER   A 1 445 ? -12.923 -101.539 -12.715 1.00 60.60  ? 446  SER   A CB  1 
ATOM   3518 O  OG  . SER   A 1 445 ? -13.489 -102.801 -13.031 1.00 61.52  ? 446  SER   A OG  1 
ATOM   3519 N  N   . PRO   A 1 446 ? -9.834  -102.259 -12.957 1.00 55.61  ? 447  PRO   A N   1 
ATOM   3520 C  CA  . PRO   A 1 446 ? -8.734  -103.150 -13.330 1.00 57.08  ? 447  PRO   A CA  1 
ATOM   3521 C  C   . PRO   A 1 446 ? -8.014  -103.799 -12.137 1.00 58.01  ? 447  PRO   A C   1 
ATOM   3522 O  O   . PRO   A 1 446 ? -7.974  -105.014 -12.092 1.00 56.30  ? 447  PRO   A O   1 
ATOM   3523 C  CB  . PRO   A 1 446 ? -7.781  -102.230 -14.107 1.00 56.55  ? 447  PRO   A CB  1 
ATOM   3524 C  CG  . PRO   A 1 446 ? -8.712  -101.229 -14.752 1.00 57.20  ? 447  PRO   A CG  1 
ATOM   3525 C  CD  . PRO   A 1 446 ? -9.798  -100.998 -13.718 1.00 56.82  ? 447  PRO   A CD  1 
ATOM   3526 N  N   . GLU   A 1 447 ? -7.485  -102.991 -11.210 1.00 58.16  ? 448  GLU   A N   1 
ATOM   3527 C  CA  . GLU   A 1 447 ? -6.661  -103.476 -10.066 1.00 58.18  ? 448  GLU   A CA  1 
ATOM   3528 C  C   . GLU   A 1 447 ? -7.537  -104.359 -9.168  1.00 59.75  ? 448  GLU   A C   1 
ATOM   3529 O  O   . GLU   A 1 447 ? -7.038  -105.407 -8.704  1.00 58.91  ? 448  GLU   A O   1 
ATOM   3530 C  CB  . GLU   A 1 447 ? -6.047  -102.317 -9.274  1.00 55.82  ? 448  GLU   A CB  1 
ATOM   3531 C  CG  . GLU   A 1 447 ? -4.969  -101.559 -10.034 1.00 53.61  ? 448  GLU   A CG  1 
ATOM   3532 C  CD  . GLU   A 1 447 ? -5.472  -100.624 -11.124 1.00 52.85  ? 448  GLU   A CD  1 
ATOM   3533 O  OE1 . GLU   A 1 447 ? -6.698  -100.352 -11.161 1.00 52.10  ? 448  GLU   A OE1 1 
ATOM   3534 O  OE2 . GLU   A 1 447 ? -4.642  -100.183 -11.948 1.00 49.24  ? 448  GLU   A OE2 1 
ATOM   3535 N  N   . CYS   A 1 448 ? -8.793  -103.950 -8.954  1.00 58.78  ? 449  CYS   A N   1 
ATOM   3536 C  CA  . CYS   A 1 448 ? -9.780  -104.633 -8.073  1.00 60.69  ? 449  CYS   A CA  1 
ATOM   3537 C  C   . CYS   A 1 448 ? -10.043 -106.052 -8.587  1.00 63.29  ? 449  CYS   A C   1 
ATOM   3538 O  O   . CYS   A 1 448 ? -9.862  -107.005 -7.802  1.00 68.11  ? 449  CYS   A O   1 
ATOM   3539 C  CB  . CYS   A 1 448 ? -11.093 -103.860 -7.985  1.00 57.97  ? 449  CYS   A CB  1 
ATOM   3540 S  SG  . CYS   A 1 448 ? -11.005 -102.417 -6.891  1.00 57.68  ? 449  CYS   A SG  1 
ATOM   3541 N  N   . LEU   A 1 449 ? -10.452 -106.177 -9.853  1.00 62.67  ? 450  LEU   A N   1 
ATOM   3542 C  CA  . LEU   A 1 449 ? -10.815 -107.470 -10.490 1.00 59.86  ? 450  LEU   A CA  1 
ATOM   3543 C  C   . LEU   A 1 449 ? -9.559  -108.330 -10.674 1.00 60.06  ? 450  LEU   A C   1 
ATOM   3544 O  O   . LEU   A 1 449 ? -9.673  -109.558 -10.530 1.00 62.45  ? 450  LEU   A O   1 
ATOM   3545 C  CB  . LEU   A 1 449 ? -11.520 -107.197 -11.822 1.00 58.13  ? 450  LEU   A CB  1 
ATOM   3546 C  CG  . LEU   A 1 449 ? -12.894 -106.536 -11.711 1.00 58.54  ? 450  LEU   A CG  1 
ATOM   3547 C  CD1 . LEU   A 1 449 ? -13.516 -106.350 -13.087 1.00 58.16  ? 450  LEU   A CD1 1 
ATOM   3548 C  CD2 . LEU   A 1 449 ? -13.826 -107.340 -10.813 1.00 58.32  ? 450  LEU   A CD2 1 
ATOM   3549 N  N   . ASP   A 1 450 ? -8.409  -107.712 -10.955 1.00 62.09  ? 451  ASP   A N   1 
ATOM   3550 C  CA  . ASP   A 1 450 ? -7.094  -108.403 -11.073 1.00 65.91  ? 451  ASP   A CA  1 
ATOM   3551 C  C   . ASP   A 1 450 ? -6.800  -109.167 -9.776  1.00 66.75  ? 451  ASP   A C   1 
ATOM   3552 O  O   . ASP   A 1 450 ? -6.316  -110.313 -9.861  1.00 67.51  ? 451  ASP   A O   1 
ATOM   3553 C  CB  . ASP   A 1 450 ? -5.954  -107.421 -11.372 1.00 67.07  ? 451  ASP   A CB  1 
ATOM   3554 C  CG  . ASP   A 1 450 ? -5.821  -107.014 -12.832 1.00 67.32  ? 451  ASP   A CG  1 
ATOM   3555 O  OD1 . ASP   A 1 450 ? -6.712  -107.371 -13.635 1.00 67.25  ? 451  ASP   A OD1 1 
ATOM   3556 O  OD2 . ASP   A 1 450 ? -4.824  -106.337 -13.154 1.00 64.77  ? 451  ASP   A OD2 1 
ATOM   3557 N  N   . GLY   A 1 451 ? -7.071  -108.546 -8.624  1.00 67.66  ? 452  GLY   A N   1 
ATOM   3558 C  CA  . GLY   A 1 451 ? -6.802  -109.117 -7.290  1.00 69.05  ? 452  GLY   A CA  1 
ATOM   3559 C  C   . GLY   A 1 451 ? -7.809  -110.190 -6.914  1.00 70.58  ? 452  GLY   A C   1 
ATOM   3560 O  O   . GLY   A 1 451 ? -7.485  -111.009 -6.035  1.00 73.44  ? 452  GLY   A O   1 
ATOM   3561 N  N   . ALA   A 1 452 ? -8.986  -110.172 -7.551  1.00 71.95  ? 453  ALA   A N   1 
ATOM   3562 C  CA  . ALA   A 1 452 ? -10.108 -111.119 -7.348  1.00 74.13  ? 453  ALA   A CA  1 
ATOM   3563 C  C   . ALA   A 1 452 ? -10.050 -112.246 -8.388  1.00 74.59  ? 453  ALA   A C   1 
ATOM   3564 O  O   . ALA   A 1 452 ? -10.794 -113.232 -8.231  1.00 70.80  ? 453  ALA   A O   1 
ATOM   3565 C  CB  . ALA   A 1 452 ? -11.419 -110.374 -7.435  1.00 74.36  ? 453  ALA   A CB  1 
ATOM   3566 N  N   . GLN   A 1 453 ? -9.197  -112.101 -9.405  1.00 77.36  ? 454  GLN   A N   1 
ATOM   3567 C  CA  . GLN   A 1 453 ? -9.143  -112.989 -10.598 1.00 79.01  ? 454  GLN   A CA  1 
ATOM   3568 C  C   . GLN   A 1 453 ? -8.827  -114.429 -10.173 1.00 78.89  ? 454  GLN   A C   1 
ATOM   3569 O  O   . GLN   A 1 453 ? -9.396  -115.350 -10.782 1.00 79.93  ? 454  GLN   A O   1 
ATOM   3570 C  CB  . GLN   A 1 453 ? -8.101  -112.472 -11.592 1.00 80.19  ? 454  GLN   A CB  1 
ATOM   3571 C  CG  . GLN   A 1 453 ? -8.236  -113.078 -12.981 1.00 80.98  ? 454  GLN   A CG  1 
ATOM   3572 C  CD  . GLN   A 1 453 ? -7.469  -112.302 -14.024 1.00 79.76  ? 454  GLN   A CD  1 
ATOM   3573 O  OE1 . GLN   A 1 453 ? -8.023  -111.882 -15.035 1.00 85.07  ? 454  GLN   A OE1 1 
ATOM   3574 N  NE2 . GLN   A 1 453 ? -6.185  -112.098 -13.782 1.00 76.74  ? 454  GLN   A NE2 1 
ATOM   3575 N  N   . HIS   A 1 454 ? -7.976  -114.607 -9.156  1.00 81.27  ? 455  HIS   A N   1 
ATOM   3576 C  CA  . HIS   A 1 454 ? -7.418  -115.919 -8.725  1.00 82.00  ? 455  HIS   A CA  1 
ATOM   3577 C  C   . HIS   A 1 454 ? -8.513  -116.863 -8.203  1.00 82.62  ? 455  HIS   A C   1 
ATOM   3578 O  O   . HIS   A 1 454 ? -8.217  -118.072 -8.105  1.00 92.17  ? 455  HIS   A O   1 
ATOM   3579 C  CB  . HIS   A 1 454 ? -6.296  -115.728 -7.693  1.00 84.60  ? 455  HIS   A CB  1 
ATOM   3580 C  CG  . HIS   A 1 454 ? -6.746  -115.174 -6.381  1.00 88.66  ? 455  HIS   A CG  1 
ATOM   3581 N  ND1 . HIS   A 1 454 ? -7.662  -115.824 -5.577  1.00 88.89  ? 455  HIS   A ND1 1 
ATOM   3582 C  CD2 . HIS   A 1 454 ? -6.389  -114.054 -5.717  1.00 91.69  ? 455  HIS   A CD2 1 
ATOM   3583 C  CE1 . HIS   A 1 454 ? -7.859  -115.120 -4.482  1.00 87.40  ? 455  HIS   A CE1 1 
ATOM   3584 N  NE2 . HIS   A 1 454 ? -7.092  -114.030 -4.544  1.00 91.19  ? 455  HIS   A NE2 1 
ATOM   3585 N  N   . PHE   A 1 455 ? -9.711  -116.364 -7.867  1.00 77.18  ? 456  PHE   A N   1 
ATOM   3586 C  CA  . PHE   A 1 455 ? -10.857 -117.209 -7.426  1.00 77.16  ? 456  PHE   A CA  1 
ATOM   3587 C  C   . PHE   A 1 455 ? -11.996 -117.190 -8.458  1.00 75.55  ? 456  PHE   A C   1 
ATOM   3588 O  O   . PHE   A 1 455 ? -13.154 -117.457 -8.075  1.00 68.12  ? 456  PHE   A O   1 
ATOM   3589 C  CB  . PHE   A 1 455 ? -11.327 -116.833 -6.017  1.00 77.13  ? 456  PHE   A CB  1 
ATOM   3590 C  CG  . PHE   A 1 455 ? -11.777 -115.411 -5.788  1.00 74.39  ? 456  PHE   A CG  1 
ATOM   3591 C  CD1 . PHE   A 1 455 ? -12.781 -114.833 -6.545  1.00 73.28  ? 456  PHE   A CD1 1 
ATOM   3592 C  CD2 . PHE   A 1 455 ? -11.229 -114.663 -4.757  1.00 76.62  ? 456  PHE   A CD2 1 
ATOM   3593 C  CE1 . PHE   A 1 455 ? -13.197 -113.532 -6.301  1.00 74.88  ? 456  PHE   A CE1 1 
ATOM   3594 C  CE2 . PHE   A 1 455 ? -11.650 -113.366 -4.511  1.00 75.49  ? 456  PHE   A CE2 1 
ATOM   3595 C  CZ  . PHE   A 1 455 ? -12.639 -112.804 -5.280  1.00 74.49  ? 456  PHE   A CZ  1 
ATOM   3596 N  N   . LEU   A 1 456 ? -11.675 -116.915 -9.726  1.00 80.29  ? 457  LEU   A N   1 
ATOM   3597 C  CA  . LEU   A 1 456 ? -12.550 -117.209 -10.894 1.00 83.60  ? 457  LEU   A CA  1 
ATOM   3598 C  C   . LEU   A 1 456 ? -12.075 -118.532 -11.507 1.00 86.40  ? 457  LEU   A C   1 
ATOM   3599 O  O   . LEU   A 1 456 ? -10.840 -118.717 -11.616 1.00 81.22  ? 457  LEU   A O   1 
ATOM   3600 C  CB  . LEU   A 1 456 ? -12.465 -116.052 -11.896 1.00 82.80  ? 457  LEU   A CB  1 
ATOM   3601 C  CG  . LEU   A 1 456 ? -13.413 -116.129 -13.093 1.00 84.70  ? 457  LEU   A CG  1 
ATOM   3602 C  CD1 . LEU   A 1 456 ? -14.866 -115.976 -12.665 1.00 83.43  ? 457  LEU   A CD1 1 
ATOM   3603 C  CD2 . LEU   A 1 456 ? -13.057 -115.075 -14.131 1.00 85.32  ? 457  LEU   A CD2 1 
ATOM   3604 N  N   . LYS   A 1 457 ? -13.005 -119.430 -11.854 1.00 86.30  ? 458  LYS   A N   1 
ATOM   3605 C  CA  . LYS   A 1 457 ? -12.685 -120.744 -12.477 1.00 91.71  ? 458  LYS   A CA  1 
ATOM   3606 C  C   . LYS   A 1 457 ? -11.918 -120.499 -13.782 1.00 92.89  ? 458  LYS   A C   1 
ATOM   3607 O  O   . LYS   A 1 457 ? -12.141 -119.439 -14.403 1.00 91.53  ? 458  LYS   A O   1 
ATOM   3608 C  CB  . LYS   A 1 457 ? -13.953 -121.561 -12.746 1.00 96.77  ? 458  LYS   A CB  1 
ATOM   3609 C  CG  . LYS   A 1 457 ? -14.508 -122.325 -11.551 1.00 100.62 ? 458  LYS   A CG  1 
ATOM   3610 C  CD  . LYS   A 1 457 ? -15.646 -123.258 -11.911 1.00 104.40 ? 458  LYS   A CD  1 
ATOM   3611 C  CE  . LYS   A 1 457 ? -16.504 -123.639 -10.723 1.00 108.20 ? 458  LYS   A CE  1 
ATOM   3612 N  NZ  . LYS   A 1 457 ? -17.577 -124.588 -11.105 1.00 112.91 ? 458  LYS   A NZ  1 
ATOM   3613 N  N   . ASP   A 1 458 ? -11.073 -121.456 -14.188 1.00 91.58  ? 459  ASP   A N   1 
ATOM   3614 C  CA  . ASP   A 1 458 ? -10.263 -121.406 -15.439 1.00 87.73  ? 459  ASP   A CA  1 
ATOM   3615 C  C   . ASP   A 1 458 ? -11.140 -120.968 -16.621 1.00 82.31  ? 459  ASP   A C   1 
ATOM   3616 O  O   . ASP   A 1 458 ? -10.607 -120.284 -17.516 1.00 79.15  ? 459  ASP   A O   1 
ATOM   3617 C  CB  . ASP   A 1 458 ? -9.603  -122.755 -15.739 1.00 89.64  ? 459  ASP   A CB  1 
ATOM   3618 C  CG  . ASP   A 1 458 ? -8.582  -123.197 -14.701 1.00 94.48  ? 459  ASP   A CG  1 
ATOM   3619 O  OD1 . ASP   A 1 458 ? -7.805  -122.338 -14.231 1.00 95.00  ? 459  ASP   A OD1 1 
ATOM   3620 O  OD2 . ASP   A 1 458 ? -8.575  -124.399 -14.368 1.00 97.17  ? 459  ASP   A OD2 1 
ATOM   3621 N  N   . ASP   A 1 459 ? -12.426 -121.345 -16.614 1.00 79.35  ? 460  ASP   A N   1 
ATOM   3622 C  CA  . ASP   A 1 459 ? -13.411 -121.078 -17.700 1.00 78.77  ? 460  ASP   A CA  1 
ATOM   3623 C  C   . ASP   A 1 459 ? -14.428 -120.014 -17.256 1.00 74.74  ? 460  ASP   A C   1 
ATOM   3624 O  O   . ASP   A 1 459 ? -15.449 -119.848 -17.952 1.00 67.71  ? 460  ASP   A O   1 
ATOM   3625 C  CB  . ASP   A 1 459 ? -14.114 -122.379 -18.104 1.00 81.96  ? 460  ASP   A CB  1 
ATOM   3626 C  CG  . ASP   A 1 459 ? -14.959 -122.986 -16.995 1.00 85.88  ? 460  ASP   A CG  1 
ATOM   3627 O  OD1 . ASP   A 1 459 ? -16.131 -122.581 -16.868 1.00 83.78  ? 460  ASP   A OD1 1 
ATOM   3628 O  OD2 . ASP   A 1 459 ? -14.432 -123.842 -16.250 1.00 88.45  ? 460  ASP   A OD2 1 
ATOM   3629 N  N   . GLY   A 1 460 ? -14.159 -119.302 -16.157 1.00 75.97  ? 461  GLY   A N   1 
ATOM   3630 C  CA  . GLY   A 1 460 ? -15.113 -118.365 -15.532 1.00 76.37  ? 461  GLY   A CA  1 
ATOM   3631 C  C   . GLY   A 1 460 ? -15.313 -117.102 -16.358 1.00 75.75  ? 461  GLY   A C   1 
ATOM   3632 O  O   . GLY   A 1 460 ? -14.373 -116.706 -17.082 1.00 75.41  ? 461  GLY   A O   1 
ATOM   3633 N  N   . VAL   A 1 461 ? -16.498 -116.492 -16.250 1.00 71.53  ? 462  VAL   A N   1 
ATOM   3634 C  CA  . VAL   A 1 461 ? -16.886 -115.236 -16.958 1.00 70.35  ? 462  VAL   A CA  1 
ATOM   3635 C  C   . VAL   A 1 461 ? -16.825 -114.065 -15.967 1.00 71.95  ? 462  VAL   A C   1 
ATOM   3636 O  O   . VAL   A 1 461 ? -17.327 -114.223 -14.837 1.00 72.81  ? 462  VAL   A O   1 
ATOM   3637 C  CB  . VAL   A 1 461 ? -18.292 -115.363 -17.574 1.00 69.53  ? 462  VAL   A CB  1 
ATOM   3638 C  CG1 . VAL   A 1 461 ? -18.783 -114.047 -18.165 1.00 69.54  ? 462  VAL   A CG1 1 
ATOM   3639 C  CG2 . VAL   A 1 461 ? -18.351 -116.467 -18.615 1.00 70.47  ? 462  VAL   A CG2 1 
ATOM   3640 N  N   . SER   A 1 462 ? -16.245 -112.933 -16.385 1.00 70.58  ? 463  SER   A N   1 
ATOM   3641 C  CA  . SER   A 1 462 ? -16.354 -111.618 -15.700 1.00 65.41  ? 463  SER   A CA  1 
ATOM   3642 C  C   . SER   A 1 462 ? -17.456 -110.795 -16.369 1.00 62.48  ? 463  SER   A C   1 
ATOM   3643 O  O   . SER   A 1 462 ? -17.413 -110.650 -17.598 1.00 66.40  ? 463  SER   A O   1 
ATOM   3644 C  CB  . SER   A 1 462 ? -15.050 -110.866 -15.710 1.00 67.30  ? 463  SER   A CB  1 
ATOM   3645 O  OG  . SER   A 1 462 ? -15.170 -109.630 -15.015 1.00 66.75  ? 463  SER   A OG  1 
ATOM   3646 N  N   . ILE   A 1 463 ? -18.408 -110.299 -15.579 1.00 63.53  ? 464  ILE   A N   1 
ATOM   3647 C  CA  . ILE   A 1 463 ? -19.412 -109.277 -15.994 1.00 64.09  ? 464  ILE   A CA  1 
ATOM   3648 C  C   . ILE   A 1 463 ? -19.156 -108.022 -15.160 1.00 65.19  ? 464  ILE   A C   1 
ATOM   3649 O  O   . ILE   A 1 463 ? -19.517 -107.985 -13.985 1.00 66.08  ? 464  ILE   A O   1 
ATOM   3650 C  CB  . ILE   A 1 463 ? -20.844 -109.824 -15.829 1.00 66.22  ? 464  ILE   A CB  1 
ATOM   3651 C  CG1 . ILE   A 1 463 ? -21.064 -111.065 -16.701 1.00 67.97  ? 464  ILE   A CG1 1 
ATOM   3652 C  CG2 . ILE   A 1 463 ? -21.875 -108.738 -16.113 1.00 67.92  ? 464  ILE   A CG2 1 
ATOM   3653 C  CD1 . ILE   A 1 463 ? -22.411 -111.731 -16.521 1.00 69.10  ? 464  ILE   A CD1 1 
ATOM   3654 N  N   . PRO   A 1 464 ? -18.549 -106.948 -15.725 1.00 64.14  ? 465  PRO   A N   1 
ATOM   3655 C  CA  . PRO   A 1 464 ? -18.347 -106.793 -17.165 1.00 62.03  ? 465  PRO   A CA  1 
ATOM   3656 C  C   . PRO   A 1 464 ? -17.105 -107.512 -17.710 1.00 59.65  ? 465  PRO   A C   1 
ATOM   3657 O  O   . PRO   A 1 464 ? -16.200 -107.784 -16.941 1.00 58.93  ? 465  PRO   A O   1 
ATOM   3658 C  CB  . PRO   A 1 464 ? -18.168 -105.277 -17.359 1.00 63.44  ? 465  PRO   A CB  1 
ATOM   3659 C  CG  . PRO   A 1 464 ? -18.259 -104.667 -15.966 1.00 64.88  ? 465  PRO   A CG  1 
ATOM   3660 C  CD  . PRO   A 1 464 ? -18.009 -105.798 -14.993 1.00 64.72  ? 465  PRO   A CD  1 
ATOM   3661 N  N   . GLY   A 1 465 ? -17.102 -107.778 -19.020 1.00 59.27  ? 466  GLY   A N   1 
ATOM   3662 C  CA  . GLY   A 1 465 ? -16.025 -108.486 -19.741 1.00 60.28  ? 466  GLY   A CA  1 
ATOM   3663 C  C   . GLY   A 1 465 ? -14.954 -107.524 -20.223 1.00 62.94  ? 466  GLY   A C   1 
ATOM   3664 O  O   . GLY   A 1 465 ? -13.756 -107.858 -20.108 1.00 65.13  ? 466  GLY   A O   1 
ATOM   3665 N  N   . GLU   A 1 466 ? -15.361 -106.369 -20.755 1.00 64.30  ? 467  GLU   A N   1 
ATOM   3666 C  CA  . GLU   A 1 466 ? -14.427 -105.264 -21.098 1.00 65.17  ? 467  GLU   A CA  1 
ATOM   3667 C  C   . GLU   A 1 466 ? -15.118 -103.911 -20.901 1.00 59.80  ? 467  GLU   A C   1 
ATOM   3668 O  O   . GLU   A 1 466 ? -16.363 -103.858 -20.846 1.00 60.14  ? 467  GLU   A O   1 
ATOM   3669 C  CB  . GLU   A 1 466 ? -13.874 -105.424 -22.518 1.00 65.96  ? 467  GLU   A CB  1 
ATOM   3670 C  CG  . GLU   A 1 466 ? -14.867 -105.109 -23.620 1.00 70.45  ? 467  GLU   A CG  1 
ATOM   3671 C  CD  . GLU   A 1 466 ? -14.227 -104.531 -24.869 1.00 76.00  ? 467  GLU   A CD  1 
ATOM   3672 O  OE1 . GLU   A 1 466 ? -14.580 -103.385 -25.234 1.00 78.67  ? 467  GLU   A OE1 1 
ATOM   3673 O  OE2 . GLU   A 1 466 ? -13.368 -105.221 -25.465 1.00 75.09  ? 467  GLU   A OE2 1 
ATOM   3674 N  N   . TYR   A 1 467 ? -14.312 -102.863 -20.756 1.00 55.69  ? 468  TYR   A N   1 
ATOM   3675 C  CA  . TYR   A 1 467 ? -14.750 -101.448 -20.806 1.00 56.72  ? 468  TYR   A CA  1 
ATOM   3676 C  C   . TYR   A 1 467 ? -13.682 -100.651 -21.550 1.00 53.65  ? 468  TYR   A C   1 
ATOM   3677 O  O   . TYR   A 1 467 ? -12.500 -101.050 -21.551 1.00 52.05  ? 468  TYR   A O   1 
ATOM   3678 C  CB  . TYR   A 1 467 ? -15.037 -100.889 -19.409 1.00 57.96  ? 468  TYR   A CB  1 
ATOM   3679 C  CG  . TYR   A 1 467 ? -14.156 -101.416 -18.306 1.00 56.66  ? 468  TYR   A CG  1 
ATOM   3680 C  CD1 . TYR   A 1 467 ? -12.918 -100.856 -18.042 1.00 56.07  ? 468  TYR   A CD1 1 
ATOM   3681 C  CD2 . TYR   A 1 467 ? -14.569 -102.477 -17.519 1.00 57.83  ? 468  TYR   A CD2 1 
ATOM   3682 C  CE1 . TYR   A 1 467 ? -12.113 -101.337 -17.022 1.00 56.81  ? 468  TYR   A CE1 1 
ATOM   3683 C  CE2 . TYR   A 1 467 ? -13.775 -102.973 -16.499 1.00 57.02  ? 468  TYR   A CE2 1 
ATOM   3684 C  CZ  . TYR   A 1 467 ? -12.546 -102.399 -16.247 1.00 55.62  ? 468  TYR   A CZ  1 
ATOM   3685 O  OH  . TYR   A 1 467 ? -11.788 -102.901 -15.233 1.00 55.74  ? 468  TYR   A OH  1 
ATOM   3686 N  N   . THR   A 1 468 ? -14.115 -99.583  -22.210 1.00 53.24  ? 469  THR   A N   1 
ATOM   3687 C  CA  . THR   A 1 468 ? -13.242 -98.689  -23.002 1.00 54.60  ? 469  THR   A CA  1 
ATOM   3688 C  C   . THR   A 1 468 ? -13.578 -97.240  -22.649 1.00 54.24  ? 469  THR   A C   1 
ATOM   3689 O  O   . THR   A 1 468 ? -14.777 -96.908  -22.581 1.00 54.03  ? 469  THR   A O   1 
ATOM   3690 C  CB  . THR   A 1 468 ? -13.369 -98.996  -24.497 1.00 56.40  ? 469  THR   A CB  1 
ATOM   3691 O  OG1 . THR   A 1 468 ? -12.899 -100.333 -24.693 1.00 55.05  ? 469  THR   A OG1 1 
ATOM   3692 C  CG2 . THR   A 1 468 ? -12.588 -98.031  -25.362 1.00 56.25  ? 469  THR   A CG2 1 
ATOM   3693 N  N   . SER   A 1 469 ? -12.545 -96.429  -22.416 1.00 53.70  ? 470  SER   A N   1 
ATOM   3694 C  CA  . SER   A 1 469 ? -12.653 -94.970  -22.173 1.00 54.32  ? 470  SER   A CA  1 
ATOM   3695 C  C   . SER   A 1 469 ? -12.533 -94.228  -23.509 1.00 53.86  ? 470  SER   A C   1 
ATOM   3696 O  O   . SER   A 1 469 ? -11.863 -94.742  -24.423 1.00 51.05  ? 470  SER   A O   1 
ATOM   3697 C  CB  . SER   A 1 469 ? -11.628 -94.512  -21.158 1.00 55.13  ? 470  SER   A CB  1 
ATOM   3698 O  OG  . SER   A 1 469 ? -10.310 -94.557  -21.681 1.00 53.37  ? 470  SER   A OG  1 
ATOM   3699 N  N   . PHE   A 1 470 ? -13.195 -93.075  -23.617 1.00 54.50  ? 471  PHE   A N   1 
ATOM   3700 C  CA  . PHE   A 1 470 ? -13.193 -92.191  -24.808 1.00 54.10  ? 471  PHE   A CA  1 
ATOM   3701 C  C   . PHE   A 1 470 ? -12.851 -90.769  -24.364 1.00 54.11  ? 471  PHE   A C   1 
ATOM   3702 O  O   . PHE   A 1 470 ? -13.305 -90.366  -23.275 1.00 54.34  ? 471  PHE   A O   1 
ATOM   3703 C  CB  . PHE   A 1 470 ? -14.552 -92.230  -25.509 1.00 54.84  ? 471  PHE   A CB  1 
ATOM   3704 C  CG  . PHE   A 1 470 ? -14.814 -93.498  -26.276 1.00 56.46  ? 471  PHE   A CG  1 
ATOM   3705 C  CD1 . PHE   A 1 470 ? -15.236 -94.646  -25.624 1.00 59.32  ? 471  PHE   A CD1 1 
ATOM   3706 C  CD2 . PHE   A 1 470 ? -14.636 -93.542  -27.649 1.00 57.10  ? 471  PHE   A CD2 1 
ATOM   3707 C  CE1 . PHE   A 1 470 ? -15.471 -95.815  -26.332 1.00 60.16  ? 471  PHE   A CE1 1 
ATOM   3708 C  CE2 . PHE   A 1 470 ? -14.872 -94.712  -28.353 1.00 58.24  ? 471  PHE   A CE2 1 
ATOM   3709 C  CZ  . PHE   A 1 470 ? -15.290 -95.845  -27.694 1.00 58.79  ? 471  PHE   A CZ  1 
ATOM   3710 N  N   . LEU   A 1 471 ? -12.076 -90.056  -25.186 1.00 52.85  ? 472  LEU   A N   1 
ATOM   3711 C  CA  . LEU   A 1 471 ? -11.743 -88.619  -25.015 1.00 53.75  ? 472  LEU   A CA  1 
ATOM   3712 C  C   . LEU   A 1 471 ? -12.216 -87.847  -26.247 1.00 54.59  ? 472  LEU   A C   1 
ATOM   3713 O  O   . LEU   A 1 471 ? -12.205 -88.426  -27.355 1.00 56.96  ? 472  LEU   A O   1 
ATOM   3714 C  CB  . LEU   A 1 471 ? -10.230 -88.452  -24.842 1.00 53.94  ? 472  LEU   A CB  1 
ATOM   3715 C  CG  . LEU   A 1 471 ? -9.657  -88.869  -23.491 1.00 52.64  ? 472  LEU   A CG  1 
ATOM   3716 C  CD1 . LEU   A 1 471 ? -8.138  -88.899  -23.550 1.00 53.54  ? 472  LEU   A CD1 1 
ATOM   3717 C  CD2 . LEU   A 1 471 ? -10.133 -87.944  -22.384 1.00 51.08  ? 472  LEU   A CD2 1 
ATOM   3718 N  N   . ALA   A 1 472 ? -12.595 -86.585  -26.047 1.00 53.31  ? 473  ALA   A N   1 
ATOM   3719 C  CA  . ALA   A 1 472 ? -12.871 -85.596  -27.111 1.00 53.32  ? 473  ALA   A CA  1 
ATOM   3720 C  C   . ALA   A 1 472 ? -12.350 -84.241  -26.647 1.00 53.03  ? 473  ALA   A C   1 
ATOM   3721 O  O   . ALA   A 1 472 ? -12.525 -83.889  -25.485 1.00 52.96  ? 473  ALA   A O   1 
ATOM   3722 C  CB  . ALA   A 1 472 ? -14.350 -85.560  -27.406 1.00 52.02  ? 473  ALA   A CB  1 
ATOM   3723 N  N   . PRO   A 1 473 ? -11.690 -83.445  -27.517 1.00 52.23  ? 474  PRO   A N   1 
ATOM   3724 C  CA  . PRO   A 1 473 ? -11.269 -82.098  -27.147 1.00 54.33  ? 474  PRO   A CA  1 
ATOM   3725 C  C   . PRO   A 1 473 ? -12.500 -81.186  -27.076 1.00 53.65  ? 474  PRO   A C   1 
ATOM   3726 O  O   . PRO   A 1 473 ? -13.383 -81.356  -27.892 1.00 56.39  ? 474  PRO   A O   1 
ATOM   3727 C  CB  . PRO   A 1 473 ? -10.306 -81.682  -28.270 1.00 55.27  ? 474  PRO   A CB  1 
ATOM   3728 C  CG  . PRO   A 1 473 ? -10.734 -82.509  -29.463 1.00 54.81  ? 474  PRO   A CG  1 
ATOM   3729 C  CD  . PRO   A 1 473 ? -11.334 -83.783  -28.900 1.00 54.03  ? 474  PRO   A CD  1 
ATOM   3730 N  N   . ILE   A 1 474 ? -12.542 -80.266  -26.110 1.00 52.42  ? 475  ILE   A N   1 
ATOM   3731 C  CA  . ILE   A 1 474 ? -13.666 -79.295  -25.966 1.00 54.21  ? 475  ILE   A CA  1 
ATOM   3732 C  C   . ILE   A 1 474 ? -13.125 -77.866  -25.903 1.00 54.43  ? 475  ILE   A C   1 
ATOM   3733 O  O   . ILE   A 1 474 ? -11.999 -77.659  -25.408 1.00 54.95  ? 475  ILE   A O   1 
ATOM   3734 C  CB  . ILE   A 1 474 ? -14.541 -79.598  -24.736 1.00 54.82  ? 475  ILE   A CB  1 
ATOM   3735 C  CG1 . ILE   A 1 474 ? -13.758 -79.474  -23.428 1.00 55.66  ? 475  ILE   A CG1 1 
ATOM   3736 C  CG2 . ILE   A 1 474 ? -15.210 -80.956  -24.865 1.00 55.90  ? 475  ILE   A CG2 1 
ATOM   3737 C  CD1 . ILE   A 1 474 ? -14.624 -79.153  -22.238 1.00 58.27  ? 475  ILE   A CD1 1 
ATOM   3738 N  N   . SER   A 1 475 ? -13.944 -76.924  -26.370 1.00 53.59  ? 476  SER   A N   1 
ATOM   3739 C  CA  . SER   A 1 475 ? -13.823 -75.471  -26.105 1.00 55.64  ? 476  SER   A CA  1 
ATOM   3740 C  C   . SER   A 1 475 ? -14.886 -75.082  -25.079 1.00 55.41  ? 476  SER   A C   1 
ATOM   3741 O  O   . SER   A 1 475 ? -16.062 -75.419  -25.290 1.00 61.11  ? 476  SER   A O   1 
ATOM   3742 C  CB  . SER   A 1 475 ? -13.972 -74.670  -27.368 1.00 56.28  ? 476  SER   A CB  1 
ATOM   3743 O  OG  . SER   A 1 475 ? -13.523 -73.341  -27.165 1.00 56.05  ? 476  SER   A OG  1 
ATOM   3744 N  N   . SER   A 1 476 ? -14.478 -74.433  -23.995 1.00 54.43  ? 477  SER   A N   1 
ATOM   3745 C  CA  . SER   A 1 476 ? -15.393 -73.764  -23.040 1.00 53.40  ? 477  SER   A CA  1 
ATOM   3746 C  C   . SER   A 1 476 ? -14.609 -72.762  -22.200 1.00 53.02  ? 477  SER   A C   1 
ATOM   3747 O  O   . SER   A 1 476 ? -14.045 -73.162  -21.161 1.00 52.42  ? 477  SER   A O   1 
ATOM   3748 C  CB  . SER   A 1 476 ? -16.101 -74.747  -22.169 1.00 54.26  ? 477  SER   A CB  1 
ATOM   3749 O  OG  . SER   A 1 476 ? -16.708 -74.072  -21.074 1.00 59.66  ? 477  SER   A OG  1 
ATOM   3750 N  N   . SER   A 1 477 ? -14.592 -71.503  -22.628 1.00 54.68  ? 478  SER   A N   1 
ATOM   3751 C  CA  . SER   A 1 477 ? -14.030 -70.384  -21.833 1.00 58.30  ? 478  SER   A CA  1 
ATOM   3752 C  C   . SER   A 1 477 ? -14.724 -70.369  -20.462 1.00 59.90  ? 478  SER   A C   1 
ATOM   3753 O  O   . SER   A 1 477 ? -14.066 -70.025  -19.469 1.00 62.75  ? 478  SER   A O   1 
ATOM   3754 C  CB  . SER   A 1 477 ? -14.149 -69.073  -22.576 1.00 59.03  ? 478  SER   A CB  1 
ATOM   3755 O  OG  . SER   A 1 477 ? -13.594 -69.176  -23.888 1.00 56.69  ? 478  SER   A OG  1 
ATOM   3756 N  N   . LYS   A 1 478 ? -15.989 -70.798  -20.407 1.00 61.52  ? 479  LYS   A N   1 
ATOM   3757 C  CA  . LYS   A 1 478 ? -16.806 -70.852  -19.163 1.00 65.71  ? 479  LYS   A CA  1 
ATOM   3758 C  C   . LYS   A 1 478 ? -16.196 -71.858  -18.174 1.00 62.49  ? 479  LYS   A C   1 
ATOM   3759 O  O   . LYS   A 1 478 ? -15.884 -71.445  -17.044 1.00 58.39  ? 479  LYS   A O   1 
ATOM   3760 C  CB  . LYS   A 1 478 ? -18.262 -71.193  -19.504 1.00 69.19  ? 479  LYS   A CB  1 
ATOM   3761 C  CG  . LYS   A 1 478 ? -19.167 -71.496  -18.317 1.00 73.19  ? 479  LYS   A CG  1 
ATOM   3762 C  CD  . LYS   A 1 478 ? -19.212 -70.407  -17.260 1.00 79.42  ? 479  LYS   A CD  1 
ATOM   3763 C  CE  . LYS   A 1 478 ? -20.036 -70.788  -16.045 1.00 83.41  ? 479  LYS   A CE  1 
ATOM   3764 N  NZ  . LYS   A 1 478 ? -21.362 -71.342  -16.418 1.00 86.06  ? 479  LYS   A NZ  1 
ATOM   3765 N  N   . LEU   A 1 479 ? -16.051 -73.125  -18.578 1.00 59.89  ? 480  LEU   A N   1 
ATOM   3766 C  CA  . LEU   A 1 479 ? -15.523 -74.218  -17.713 1.00 58.03  ? 480  LEU   A CA  1 
ATOM   3767 C  C   . LEU   A 1 479 ? -14.066 -73.927  -17.341 1.00 57.15  ? 480  LEU   A C   1 
ATOM   3768 O  O   . LEU   A 1 479 ? -13.708 -74.153  -16.168 1.00 53.32  ? 480  LEU   A O   1 
ATOM   3769 C  CB  . LEU   A 1 479 ? -15.640 -75.564  -18.435 1.00 58.60  ? 480  LEU   A CB  1 
ATOM   3770 C  CG  . LEU   A 1 479 ? -17.020 -76.214  -18.393 1.00 58.11  ? 480  LEU   A CG  1 
ATOM   3771 C  CD1 . LEU   A 1 479 ? -17.112 -77.346  -19.404 1.00 57.26  ? 480  LEU   A CD1 1 
ATOM   3772 C  CD2 . LEU   A 1 479 ? -17.343 -76.718  -16.992 1.00 57.32  ? 480  LEU   A CD2 1 
ATOM   3773 N  N   . TYR   A 1 480 ? -13.258 -73.450  -18.295 1.00 56.33  ? 481  TYR   A N   1 
ATOM   3774 C  CA  . TYR   A 1 480 ? -11.866 -72.993  -18.044 1.00 55.75  ? 481  TYR   A CA  1 
ATOM   3775 C  C   . TYR   A 1 480 ? -11.864 -72.035  -16.851 1.00 54.81  ? 481  TYR   A C   1 
ATOM   3776 O  O   . TYR   A 1 480 ? -11.007 -72.170  -15.971 1.00 56.81  ? 481  TYR   A O   1 
ATOM   3777 C  CB  . TYR   A 1 480 ? -11.255 -72.302  -19.265 1.00 56.62  ? 481  TYR   A CB  1 
ATOM   3778 C  CG  . TYR   A 1 480 ? -9.898  -71.701  -18.995 1.00 58.21  ? 481  TYR   A CG  1 
ATOM   3779 C  CD1 . TYR   A 1 480 ? -8.788  -72.510  -18.799 1.00 59.63  ? 481  TYR   A CD1 1 
ATOM   3780 C  CD2 . TYR   A 1 480 ? -9.722  -70.328  -18.908 1.00 60.00  ? 481  TYR   A CD2 1 
ATOM   3781 C  CE1 . TYR   A 1 480 ? -7.538  -71.973  -18.540 1.00 60.35  ? 481  TYR   A CE1 1 
ATOM   3782 C  CE2 . TYR   A 1 480 ? -8.478  -69.773  -18.651 1.00 60.58  ? 481  TYR   A CE2 1 
ATOM   3783 C  CZ  . TYR   A 1 480 ? -7.382  -70.599  -18.467 1.00 62.79  ? 481  TYR   A CZ  1 
ATOM   3784 O  OH  . TYR   A 1 480 ? -6.155  -70.064  -18.204 1.00 66.60  ? 481  TYR   A OH  1 
ATOM   3785 N  N   . ASN   A 1 481 ? -12.818 -71.103  -16.822 1.00 57.25  ? 482  ASN   A N   1 
ATOM   3786 C  CA  . ASN   A 1 481 ? -12.923 -70.064  -15.765 1.00 58.60  ? 482  ASN   A CA  1 
ATOM   3787 C  C   . ASN   A 1 481 ? -13.408 -70.709  -14.461 1.00 55.58  ? 482  ASN   A C   1 
ATOM   3788 O  O   . ASN   A 1 481 ? -12.922 -70.294  -13.393 1.00 54.63  ? 482  ASN   A O   1 
ATOM   3789 C  CB  . ASN   A 1 481 ? -13.822 -68.902  -16.199 1.00 62.49  ? 482  ASN   A CB  1 
ATOM   3790 C  CG  . ASN   A 1 481 ? -13.204 -67.550  -15.916 1.00 63.21  ? 482  ASN   A CG  1 
ATOM   3791 O  OD1 . ASN   A 1 481 ? -12.046 -67.464  -15.515 1.00 68.38  ? 482  ASN   A OD1 1 
ATOM   3792 N  ND2 . ASN   A 1 481 ? -13.961 -66.490  -16.140 1.00 64.32  ? 482  ASN   A ND2 1 
ATOM   3793 N  N   . GLU   A 1 482 ? -14.331 -71.674  -14.548 1.00 55.93  ? 483  GLU   A N   1 
ATOM   3794 C  CA  . GLU   A 1 482 ? -14.802 -72.496  -13.400 1.00 56.84  ? 483  GLU   A CA  1 
ATOM   3795 C  C   . GLU   A 1 482 ? -13.591 -73.174  -12.748 1.00 54.93  ? 483  GLU   A C   1 
ATOM   3796 O  O   . GLU   A 1 482 ? -13.428 -73.041  -11.522 1.00 53.16  ? 483  GLU   A O   1 
ATOM   3797 C  CB  . GLU   A 1 482 ? -15.822 -73.548  -13.846 1.00 62.29  ? 483  GLU   A CB  1 
ATOM   3798 C  CG  . GLU   A 1 482 ? -17.175 -72.977  -14.231 1.00 66.29  ? 483  GLU   A CG  1 
ATOM   3799 C  CD  . GLU   A 1 482 ? -18.042 -72.567  -13.054 1.00 75.47  ? 483  GLU   A CD  1 
ATOM   3800 O  OE1 . GLU   A 1 482 ? -18.587 -71.444  -13.090 1.00 86.39  ? 483  GLU   A OE1 1 
ATOM   3801 O  OE2 . GLU   A 1 482 ? -18.177 -73.370  -12.103 1.00 84.41  ? 483  GLU   A OE2 1 
ATOM   3802 N  N   . VAL   A 1 483 ? -12.770 -73.861  -13.549 1.00 54.95  ? 484  VAL   A N   1 
ATOM   3803 C  CA  . VAL   A 1 483 ? -11.549 -74.586  -13.082 1.00 55.19  ? 484  VAL   A CA  1 
ATOM   3804 C  C   . VAL   A 1 483 ? -10.602 -73.569  -12.431 1.00 55.72  ? 484  VAL   A C   1 
ATOM   3805 O  O   . VAL   A 1 483 ? -10.206 -73.784  -11.273 1.00 54.48  ? 484  VAL   A O   1 
ATOM   3806 C  CB  . VAL   A 1 483 ? -10.860 -75.346  -14.232 1.00 54.07  ? 484  VAL   A CB  1 
ATOM   3807 C  CG1 . VAL   A 1 483 ? -9.516  -75.922  -13.807 1.00 54.69  ? 484  VAL   A CG1 1 
ATOM   3808 C  CG2 . VAL   A 1 483 ? -11.749 -76.442  -14.803 1.00 52.30  ? 484  VAL   A CG2 1 
ATOM   3809 N  N   . ARG   A 1 484 ? -10.277 -72.498  -13.156 1.00 55.38  ? 485  ARG   A N   1 
ATOM   3810 C  CA  . ARG   A 1 484 ? -9.405  -71.384  -12.695 1.00 59.73  ? 485  ARG   A CA  1 
ATOM   3811 C  C   . ARG   A 1 484 ? -9.800  -70.960  -11.277 1.00 59.59  ? 485  ARG   A C   1 
ATOM   3812 O  O   . ARG   A 1 484 ? -8.900  -70.663  -10.466 1.00 61.83  ? 485  ARG   A O   1 
ATOM   3813 C  CB  . ARG   A 1 484 ? -9.549  -70.196  -13.649 1.00 63.72  ? 485  ARG   A CB  1 
ATOM   3814 C  CG  . ARG   A 1 484 ? -8.273  -69.403  -13.869 1.00 67.06  ? 485  ARG   A CG  1 
ATOM   3815 C  CD  . ARG   A 1 484 ? -8.302  -68.747  -15.235 1.00 71.90  ? 485  ARG   A CD  1 
ATOM   3816 N  NE  . ARG   A 1 484 ? -7.439  -67.578  -15.284 1.00 75.52  ? 485  ARG   A NE  1 
ATOM   3817 C  CZ  . ARG   A 1 484 ? -7.790  -66.355  -14.905 1.00 77.07  ? 485  ARG   A CZ  1 
ATOM   3818 N  NH1 . ARG   A 1 484 ? -6.914  -65.370  -14.998 1.00 79.83  ? 485  ARG   A NH1 1 
ATOM   3819 N  NH2 . ARG   A 1 484 ? -9.006  -66.111  -14.441 1.00 77.44  ? 485  ARG   A NH2 1 
ATOM   3820 N  N   . ALA   A 1 485 ? -11.104 -70.943  -10.995 1.00 58.92  ? 486  ALA   A N   1 
ATOM   3821 C  CA  . ALA   A 1 485 ? -11.697 -70.442  -9.735  1.00 58.25  ? 486  ALA   A CA  1 
ATOM   3822 C  C   . ALA   A 1 485 ? -11.617 -71.495  -8.622  1.00 57.23  ? 486  ALA   A C   1 
ATOM   3823 O  O   . ALA   A 1 485 ? -12.172 -71.223  -7.544  1.00 59.42  ? 486  ALA   A O   1 
ATOM   3824 C  CB  . ALA   A 1 485 ? -13.126 -70.026  -9.988  1.00 59.32  ? 486  ALA   A CB  1 
ATOM   3825 N  N   . CYS   A 1 486 ? -10.972 -72.645  -8.853  1.00 57.27  ? 487  CYS   A N   1 
ATOM   3826 C  CA  . CYS   A 1 486 ? -10.833 -73.737  -7.848  1.00 57.33  ? 487  CYS   A CA  1 
ATOM   3827 C  C   . CYS   A 1 486 ? -9.450  -73.698  -7.190  1.00 56.53  ? 487  CYS   A C   1 
ATOM   3828 O  O   . CYS   A 1 486 ? -9.038  -74.726  -6.627  1.00 57.46  ? 487  CYS   A O   1 
ATOM   3829 C  CB  . CYS   A 1 486 ? -11.071 -75.110  -8.466  1.00 58.20  ? 487  CYS   A CB  1 
ATOM   3830 S  SG  . CYS   A 1 486 ? -12.776 -75.347  -9.025  1.00 62.92  ? 487  CYS   A SG  1 
ATOM   3831 N  N   . ARG   A 1 487 ? -8.761  -72.559  -7.232  1.00 58.32  ? 488  ARG   A N   1 
ATOM   3832 C  CA  . ARG   A 1 487 ? -7.495  -72.387  -6.480  1.00 59.98  ? 488  ARG   A CA  1 
ATOM   3833 C  C   . ARG   A 1 487 ? -7.792  -72.405  -4.982  1.00 59.97  ? 488  ARG   A C   1 
ATOM   3834 O  O   . ARG   A 1 487 ? -8.662  -71.640  -4.550  1.00 64.43  ? 488  ARG   A O   1 
ATOM   3835 C  CB  . ARG   A 1 487 ? -6.786  -71.078  -6.813  1.00 60.48  ? 488  ARG   A CB  1 
ATOM   3836 C  CG  . ARG   A 1 487 ? -5.368  -71.046  -6.267  1.00 63.40  ? 488  ARG   A CG  1 
ATOM   3837 C  CD  . ARG   A 1 487 ? -4.433  -70.324  -7.205  1.00 63.99  ? 488  ARG   A CD  1 
ATOM   3838 N  NE  . ARG   A 1 487 ? -4.594  -68.888  -7.083  1.00 64.91  ? 488  ARG   A NE  1 
ATOM   3839 C  CZ  . ARG   A 1 487 ? -4.128  -68.163  -6.072  1.00 65.91  ? 488  ARG   A CZ  1 
ATOM   3840 N  NH1 . ARG   A 1 487 ? -3.469  -68.740  -5.075  1.00 64.45  ? 488  ARG   A NH1 1 
ATOM   3841 N  NH2 . ARG   A 1 487 ? -4.333  -66.858  -6.067  1.00 62.48  ? 488  ARG   A NH2 1 
ATOM   3842 N  N   . GLU   A 1 488 ? -7.075  -73.241  -4.236  1.00 62.16  ? 489  GLU   A N   1 
ATOM   3843 C  CA  . GLU   A 1 488 ? -7.177  -73.366  -2.761  1.00 63.35  ? 489  GLU   A CA  1 
ATOM   3844 C  C   . GLU   A 1 488 ? -5.839  -72.964  -2.143  1.00 60.66  ? 489  GLU   A C   1 
ATOM   3845 O  O   . GLU   A 1 488 ? -4.797  -73.204  -2.778  1.00 61.70  ? 489  GLU   A O   1 
ATOM   3846 C  CB  . GLU   A 1 488 ? -7.515  -74.801  -2.363  1.00 66.98  ? 489  GLU   A CB  1 
ATOM   3847 C  CG  . GLU   A 1 488 ? -8.855  -75.288  -2.883  1.00 69.50  ? 489  GLU   A CG  1 
ATOM   3848 C  CD  . GLU   A 1 488 ? -9.145  -76.744  -2.557  1.00 74.90  ? 489  GLU   A CD  1 
ATOM   3849 O  OE1 . GLU   A 1 488 ? -8.300  -77.381  -1.882  1.00 75.18  ? 489  GLU   A OE1 1 
ATOM   3850 O  OE2 . GLU   A 1 488 ? -10.210 -77.245  -2.981  1.00 80.20  ? 489  GLU   A OE2 1 
ATOM   3851 N  N   . LYS   A 1 489 ? -5.880  -72.370  -0.953  1.00 64.21  ? 490  LYS   A N   1 
ATOM   3852 C  CA  . LYS   A 1 489 ? -4.677  -72.092  -0.126  1.00 68.30  ? 490  LYS   A CA  1 
ATOM   3853 C  C   . LYS   A 1 489 ? -3.986  -73.423  0.200   1.00 64.25  ? 490  LYS   A C   1 
ATOM   3854 O  O   . LYS   A 1 489 ? -4.623  -74.488  0.046   1.00 64.26  ? 490  LYS   A O   1 
ATOM   3855 C  CB  . LYS   A 1 489 ? -5.067  -71.325  1.143   1.00 71.34  ? 490  LYS   A CB  1 
ATOM   3856 C  CG  . LYS   A 1 489 ? -6.082  -72.015  2.046   1.00 74.93  ? 490  LYS   A CG  1 
ATOM   3857 C  CD  . LYS   A 1 489 ? -6.477  -71.181  3.246   1.00 81.31  ? 490  LYS   A CD  1 
ATOM   3858 C  CE  . LYS   A 1 489 ? -7.745  -71.664  3.924   1.00 83.41  ? 490  LYS   A CE  1 
ATOM   3859 N  NZ  . LYS   A 1 489 ? -8.956  -71.169  3.226   1.00 82.73  ? 490  LYS   A NZ  1 
ATOM   3860 N  N   . ASP   A 1 490 ? -2.716  -73.359  0.597   1.00 60.58  ? 491  ASP   A N   1 
ATOM   3861 C  CA  . ASP   A 1 490 ? -1.939  -74.505  1.143   1.00 63.40  ? 491  ASP   A CA  1 
ATOM   3862 C  C   . ASP   A 1 490 ? -1.744  -75.612  0.095   1.00 59.10  ? 491  ASP   A C   1 
ATOM   3863 O  O   . ASP   A 1 490 ? -1.522  -76.759  0.508   1.00 59.55  ? 491  ASP   A O   1 
ATOM   3864 C  CB  . ASP   A 1 490 ? -2.615  -75.098  2.384   1.00 63.65  ? 491  ASP   A CB  1 
ATOM   3865 C  CG  . ASP   A 1 490 ? -3.060  -74.073  3.413   1.00 63.65  ? 491  ASP   A CG  1 
ATOM   3866 O  OD1 . ASP   A 1 490 ? -2.739  -72.874  3.240   1.00 62.07  ? 491  ASP   A OD1 1 
ATOM   3867 O  OD2 . ASP   A 1 490 ? -3.734  -74.483  4.380   1.00 63.40  ? 491  ASP   A OD2 1 
ATOM   3868 N  N   . ARG   A 1 491 ? -1.804  -75.301  -1.202  1.00 56.64  ? 492  ARG   A N   1 
ATOM   3869 C  CA  . ARG   A 1 491 ? -1.408  -76.259  -2.270  1.00 57.74  ? 492  ARG   A CA  1 
ATOM   3870 C  C   . ARG   A 1 491 ? -0.865  -75.497  -3.487  1.00 57.70  ? 492  ARG   A C   1 
ATOM   3871 O  O   . ARG   A 1 491 ? -1.044  -74.264  -3.562  1.00 58.91  ? 492  ARG   A O   1 
ATOM   3872 C  CB  . ARG   A 1 491 ? -2.572  -77.194  -2.626  1.00 55.64  ? 492  ARG   A CB  1 
ATOM   3873 C  CG  . ARG   A 1 491 ? -3.582  -76.627  -3.611  1.00 56.12  ? 492  ARG   A CG  1 
ATOM   3874 C  CD  . ARG   A 1 491 ? -4.659  -77.632  -3.961  1.00 56.76  ? 492  ARG   A CD  1 
ATOM   3875 N  NE  . ARG   A 1 491 ? -5.673  -77.061  -4.839  1.00 56.95  ? 492  ARG   A NE  1 
ATOM   3876 C  CZ  . ARG   A 1 491 ? -6.766  -77.697  -5.253  1.00 56.46  ? 492  ARG   A CZ  1 
ATOM   3877 N  NH1 . ARG   A 1 491 ? -7.629  -77.087  -6.048  1.00 53.28  ? 492  ARG   A NH1 1 
ATOM   3878 N  NH2 . ARG   A 1 491 ? -6.998  -78.941  -4.871  1.00 59.50  ? 492  ARG   A NH2 1 
ATOM   3879 N  N   . ASP   A 1 492 ? -0.210  -76.227  -4.392  1.00 56.16  ? 493  ASP   A N   1 
ATOM   3880 C  CA  . ASP   A 1 492 ? 0.258   -75.739  -5.713  1.00 55.03  ? 493  ASP   A CA  1 
ATOM   3881 C  C   . ASP   A 1 492 ? -0.849  -74.885  -6.322  1.00 54.24  ? 493  ASP   A C   1 
ATOM   3882 O  O   . ASP   A 1 492 ? -1.975  -75.352  -6.473  1.00 51.28  ? 493  ASP   A O   1 
ATOM   3883 C  CB  . ASP   A 1 492 ? 0.650   -76.920  -6.604  1.00 56.96  ? 493  ASP   A CB  1 
ATOM   3884 C  CG  . ASP   A 1 492 ? 1.147   -76.554  -7.992  1.00 59.30  ? 493  ASP   A CG  1 
ATOM   3885 O  OD1 . ASP   A 1 492 ? 0.708   -75.517  -8.530  1.00 59.17  ? 493  ASP   A OD1 1 
ATOM   3886 O  OD2 . ASP   A 1 492 ? 1.962   -77.328  -8.531  1.00 66.41  ? 493  ASP   A OD2 1 
ATOM   3887 N  N   . PRO   A 1 493 ? -0.564  -73.614  -6.692  1.00 53.58  ? 494  PRO   A N   1 
ATOM   3888 C  CA  . PRO   A 1 493 ? -1.598  -72.704  -7.185  1.00 53.33  ? 494  PRO   A CA  1 
ATOM   3889 C  C   . PRO   A 1 493 ? -2.181  -73.056  -8.562  1.00 53.52  ? 494  PRO   A C   1 
ATOM   3890 O  O   . PRO   A 1 493 ? -3.090  -72.371  -8.986  1.00 53.82  ? 494  PRO   A O   1 
ATOM   3891 C  CB  . PRO   A 1 493 ? -0.861  -71.360  -7.255  1.00 51.80  ? 494  PRO   A CB  1 
ATOM   3892 C  CG  . PRO   A 1 493 ? 0.568   -71.751  -7.500  1.00 51.54  ? 494  PRO   A CG  1 
ATOM   3893 C  CD  . PRO   A 1 493 ? 0.764   -72.982  -6.648  1.00 50.79  ? 494  PRO   A CD  1 
ATOM   3894 N  N   . GLU   A 1 494 ? -1.657  -74.092  -9.223  1.00 53.97  ? 495  GLU   A N   1 
ATOM   3895 C  CA  . GLU   A 1 494 ? -2.138  -74.550  -10.551 1.00 55.91  ? 495  GLU   A CA  1 
ATOM   3896 C  C   . GLU   A 1 494 ? -2.678  -75.988  -10.464 1.00 55.66  ? 495  GLU   A C   1 
ATOM   3897 O  O   . GLU   A 1 494 ? -3.072  -76.530  -11.520 1.00 56.30  ? 495  GLU   A O   1 
ATOM   3898 C  CB  . GLU   A 1 494 ? -1.007  -74.427  -11.573 1.00 58.30  ? 495  GLU   A CB  1 
ATOM   3899 C  CG  . GLU   A 1 494 ? -0.689  -72.997  -11.967 1.00 60.28  ? 495  GLU   A CG  1 
ATOM   3900 C  CD  . GLU   A 1 494 ? 0.299   -72.876  -13.114 1.00 64.84  ? 495  GLU   A CD  1 
ATOM   3901 O  OE1 . GLU   A 1 494 ? -0.053  -72.249  -14.133 1.00 73.20  ? 495  GLU   A OE1 1 
ATOM   3902 O  OE2 . GLU   A 1 494 ? 1.416   -73.419  -12.993 1.00 66.66  ? 495  GLU   A OE2 1 
ATOM   3903 N  N   . ALA   A 1 495 ? -2.748  -76.567  -9.260  1.00 51.62  ? 496  ALA   A N   1 
ATOM   3904 C  CA  . ALA   A 1 495 ? -3.147  -77.976  -9.019  1.00 51.93  ? 496  ALA   A CA  1 
ATOM   3905 C  C   . ALA   A 1 495 ? -4.542  -78.257  -9.592  1.00 50.19  ? 496  ALA   A C   1 
ATOM   3906 O  O   . ALA   A 1 495 ? -4.759  -79.374  -10.091 1.00 49.64  ? 496  ALA   A O   1 
ATOM   3907 C  CB  . ALA   A 1 495 ? -3.102  -78.284  -7.543  1.00 53.19  ? 496  ALA   A CB  1 
ATOM   3908 N  N   . GLN   A 1 496 ? -5.455  -77.288  -9.511  1.00 51.28  ? 497  GLN   A N   1 
ATOM   3909 C  CA  . GLN   A 1 496 ? -6.865  -77.419  -9.976  1.00 49.54  ? 497  GLN   A CA  1 
ATOM   3910 C  C   . GLN   A 1 496 ? -6.914  -77.797  -11.465 1.00 50.06  ? 497  GLN   A C   1 
ATOM   3911 O  O   . GLN   A 1 496 ? -7.937  -78.360  -11.885 1.00 51.58  ? 497  GLN   A O   1 
ATOM   3912 C  CB  . GLN   A 1 496 ? -7.652  -76.131  -9.714  1.00 49.72  ? 497  GLN   A CB  1 
ATOM   3913 C  CG  . GLN   A 1 496 ? -7.090  -74.885  -10.390 1.00 50.51  ? 497  GLN   A CG  1 
ATOM   3914 C  CD  . GLN   A 1 496 ? -5.986  -74.215  -9.606  1.00 53.28  ? 497  GLN   A CD  1 
ATOM   3915 O  OE1 . GLN   A 1 496 ? -5.496  -74.731  -8.603  1.00 55.05  ? 497  GLN   A OE1 1 
ATOM   3916 N  NE2 . GLN   A 1 496 ? -5.571  -73.050  -10.072 1.00 55.62  ? 497  GLN   A NE2 1 
ATOM   3917 N  N   . PHE   A 1 497 ? -5.866  -77.488  -12.237 1.00 49.60  ? 498  PHE   A N   1 
ATOM   3918 C  CA  . PHE   A 1 497 ? -5.775  -77.764  -13.697 1.00 48.37  ? 498  PHE   A CA  1 
ATOM   3919 C  C   . PHE   A 1 497 ? -5.238  -79.180  -13.955 1.00 46.37  ? 498  PHE   A C   1 
ATOM   3920 O  O   . PHE   A 1 497 ? -5.361  -79.657  -15.092 1.00 47.64  ? 498  PHE   A O   1 
ATOM   3921 C  CB  . PHE   A 1 497 ? -4.868  -76.745  -14.389 1.00 48.75  ? 498  PHE   A CB  1 
ATOM   3922 C  CG  . PHE   A 1 497 ? -5.444  -75.358  -14.499 1.00 50.37  ? 498  PHE   A CG  1 
ATOM   3923 C  CD1 . PHE   A 1 497 ? -6.545  -75.115  -15.302 1.00 49.15  ? 498  PHE   A CD1 1 
ATOM   3924 C  CD2 . PHE   A 1 497 ? -4.864  -74.289  -13.830 1.00 51.95  ? 498  PHE   A CD2 1 
ATOM   3925 C  CE1 . PHE   A 1 497 ? -7.068  -73.838  -15.415 1.00 49.35  ? 498  PHE   A CE1 1 
ATOM   3926 C  CE2 . PHE   A 1 497 ? -5.386  -73.011  -13.951 1.00 50.20  ? 498  PHE   A CE2 1 
ATOM   3927 C  CZ  . PHE   A 1 497 ? -6.490  -72.791  -14.739 1.00 49.09  ? 498  PHE   A CZ  1 
ATOM   3928 N  N   . GLU   A 1 498 ? -4.665  -79.825  -12.937 1.00 43.48  ? 499  GLU   A N   1 
ATOM   3929 C  CA  . GLU   A 1 498 ? -3.964  -81.128  -13.053 1.00 43.98  ? 499  GLU   A CA  1 
ATOM   3930 C  C   . GLU   A 1 498 ? -4.805  -82.235  -12.413 1.00 44.82  ? 499  GLU   A C   1 
ATOM   3931 O  O   . GLU   A 1 498 ? -4.208  -83.196  -11.872 1.00 44.87  ? 499  GLU   A O   1 
ATOM   3932 C  CB  . GLU   A 1 498 ? -2.603  -81.026  -12.372 1.00 44.22  ? 499  GLU   A CB  1 
ATOM   3933 C  CG  . GLU   A 1 498 ? -1.702  -79.998  -13.014 1.00 44.01  ? 499  GLU   A CG  1 
ATOM   3934 C  CD  . GLU   A 1 498 ? -0.244  -80.225  -12.694 1.00 43.92  ? 499  GLU   A CD  1 
ATOM   3935 O  OE1 . GLU   A 1 498 ? 0.069   -80.373  -11.498 1.00 45.79  ? 499  GLU   A OE1 1 
ATOM   3936 O  OE2 . GLU   A 1 498 ? 0.562   -80.296  -13.642 1.00 42.85  ? 499  GLU   A OE2 1 
ATOM   3937 N  N   . MET   A 1 499 ? -6.133  -82.117  -12.474 1.00 43.82  ? 500  MET   A N   1 
ATOM   3938 C  CA  . MET   A 1 499 ? -7.049  -83.134  -11.904 1.00 45.82  ? 500  MET   A CA  1 
ATOM   3939 C  C   . MET   A 1 499 ? -8.349  -83.185  -12.696 1.00 47.03  ? 500  MET   A C   1 
ATOM   3940 O  O   . MET   A 1 499 ? -8.847  -82.161  -13.161 1.00 48.29  ? 500  MET   A O   1 
ATOM   3941 C  CB  . MET   A 1 499 ? -7.348  -82.855  -10.429 1.00 45.97  ? 500  MET   A CB  1 
ATOM   3942 C  CG  . MET   A 1 499 ? -8.038  -81.538  -10.164 1.00 47.43  ? 500  MET   A CG  1 
ATOM   3943 S  SD  . MET   A 1 499 ? -8.350  -81.327  -8.396  1.00 50.02  ? 500  MET   A SD  1 
ATOM   3944 C  CE  . MET   A 1 499 ? -6.682  -81.126  -7.776  1.00 50.31  ? 500  MET   A CE  1 
ATOM   3945 N  N   . PRO   A 1 500 ? -8.927  -84.395  -12.864 1.00 47.14  ? 501  PRO   A N   1 
ATOM   3946 C  CA  . PRO   A 1 500 ? -10.203 -84.557  -13.548 1.00 48.50  ? 501  PRO   A CA  1 
ATOM   3947 C  C   . PRO   A 1 500 ? -11.374 -84.110  -12.667 1.00 47.04  ? 501  PRO   A C   1 
ATOM   3948 O  O   . PRO   A 1 500 ? -11.295 -84.243  -11.465 1.00 47.54  ? 501  PRO   A O   1 
ATOM   3949 C  CB  . PRO   A 1 500 ? -10.267 -86.065  -13.805 1.00 50.25  ? 501  PRO   A CB  1 
ATOM   3950 C  CG  . PRO   A 1 500 ? -9.532  -86.647  -12.620 1.00 50.90  ? 501  PRO   A CG  1 
ATOM   3951 C  CD  . PRO   A 1 500 ? -8.391  -85.677  -12.384 1.00 50.07  ? 501  PRO   A CD  1 
ATOM   3952 N  N   . TYR   A 1 501 ? -12.416 -83.576  -13.298 1.00 49.53  ? 502  TYR   A N   1 
ATOM   3953 C  CA  . TYR   A 1 501 ? -13.697 -83.200  -12.653 1.00 50.57  ? 502  TYR   A CA  1 
ATOM   3954 C  C   . TYR   A 1 501 ? -14.821 -84.017  -13.289 1.00 51.75  ? 502  TYR   A C   1 
ATOM   3955 O  O   . TYR   A 1 501 ? -14.774 -84.249  -14.515 1.00 52.22  ? 502  TYR   A O   1 
ATOM   3956 C  CB  . TYR   A 1 501 ? -13.930 -81.695  -12.786 1.00 49.60  ? 502  TYR   A CB  1 
ATOM   3957 C  CG  . TYR   A 1 501 ? -12.888 -80.862  -12.086 1.00 48.65  ? 502  TYR   A CG  1 
ATOM   3958 C  CD1 . TYR   A 1 501 ? -12.970 -80.610  -10.727 1.00 47.94  ? 502  TYR   A CD1 1 
ATOM   3959 C  CD2 . TYR   A 1 501 ? -11.811 -80.338  -12.780 1.00 49.14  ? 502  TYR   A CD2 1 
ATOM   3960 C  CE1 . TYR   A 1 501 ? -12.010 -79.855  -10.074 1.00 48.54  ? 502  TYR   A CE1 1 
ATOM   3961 C  CE2 . TYR   A 1 501 ? -10.842 -79.580  -12.144 1.00 49.43  ? 502  TYR   A CE2 1 
ATOM   3962 C  CZ  . TYR   A 1 501 ? -10.939 -79.343  -10.784 1.00 48.80  ? 502  TYR   A CZ  1 
ATOM   3963 O  OH  . TYR   A 1 501 ? -9.991  -78.596  -10.152 1.00 48.82  ? 502  TYR   A OH  1 
ATOM   3964 N  N   . VAL   A 1 502 ? -15.765 -84.479  -12.470 1.00 53.70  ? 503  VAL   A N   1 
ATOM   3965 C  CA  . VAL   A 1 502 ? -17.112 -84.913  -12.938 1.00 55.80  ? 503  VAL   A CA  1 
ATOM   3966 C  C   . VAL   A 1 502 ? -17.942 -83.636  -13.054 1.00 54.07  ? 503  VAL   A C   1 
ATOM   3967 O  O   . VAL   A 1 502 ? -17.994 -82.875  -12.072 1.00 56.05  ? 503  VAL   A O   1 
ATOM   3968 C  CB  . VAL   A 1 502 ? -17.766 -85.949  -12.002 1.00 58.26  ? 503  VAL   A CB  1 
ATOM   3969 C  CG1 . VAL   A 1 502 ? -19.213 -86.229  -12.383 1.00 60.88  ? 503  VAL   A CG1 1 
ATOM   3970 C  CG2 . VAL   A 1 502 ? -16.985 -87.248  -11.980 1.00 60.59  ? 503  VAL   A CG2 1 
ATOM   3971 N  N   . VAL   A 1 503 ? -18.541 -83.406  -14.218 1.00 53.69  ? 504  VAL   A N   1 
ATOM   3972 C  CA  . VAL   A 1 503 ? -19.305 -82.166  -14.528 1.00 55.50  ? 504  VAL   A CA  1 
ATOM   3973 C  C   . VAL   A 1 503 ? -20.311 -82.484  -15.635 1.00 57.82  ? 504  VAL   A C   1 
ATOM   3974 O  O   . VAL   A 1 503 ? -19.915 -83.131  -16.628 1.00 57.99  ? 504  VAL   A O   1 
ATOM   3975 C  CB  . VAL   A 1 503 ? -18.348 -81.025  -14.930 1.00 55.33  ? 504  VAL   A CB  1 
ATOM   3976 C  CG1 . VAL   A 1 503 ? -17.277 -81.490  -15.911 1.00 51.75  ? 504  VAL   A CG1 1 
ATOM   3977 C  CG2 . VAL   A 1 503 ? -19.095 -79.819  -15.480 1.00 54.30  ? 504  VAL   A CG2 1 
ATOM   3978 N  N   . ARG   A 1 504 ? -21.565 -82.063  -15.465 1.00 60.91  ? 505  ARG   A N   1 
ATOM   3979 C  CA  . ARG   A 1 504 ? -22.560 -82.033  -16.567 1.00 65.29  ? 505  ARG   A CA  1 
ATOM   3980 C  C   . ARG   A 1 504 ? -22.137 -80.905  -17.511 1.00 62.92  ? 505  ARG   A C   1 
ATOM   3981 O  O   . ARG   A 1 504 ? -22.600 -79.773  -17.310 1.00 66.12  ? 505  ARG   A O   1 
ATOM   3982 C  CB  . ARG   A 1 504 ? -23.984 -81.865  -16.020 1.00 70.68  ? 505  ARG   A CB  1 
ATOM   3983 C  CG  . ARG   A 1 504 ? -25.073 -81.755  -17.082 1.00 76.10  ? 505  ARG   A CG  1 
ATOM   3984 C  CD  . ARG   A 1 504 ? -25.139 -82.949  -18.025 1.00 82.10  ? 505  ARG   A CD  1 
ATOM   3985 N  NE  . ARG   A 1 504 ? -24.256 -82.801  -19.183 1.00 86.79  ? 505  ARG   A NE  1 
ATOM   3986 C  CZ  . ARG   A 1 504 ? -23.923 -83.771  -20.036 1.00 85.83  ? 505  ARG   A CZ  1 
ATOM   3987 N  NH1 . ARG   A 1 504 ? -24.399 -84.998  -19.888 1.00 88.71  ? 505  ARG   A NH1 1 
ATOM   3988 N  NH2 . ARG   A 1 504 ? -23.104 -83.505  -21.041 1.00 82.66  ? 505  ARG   A NH2 1 
ATOM   3989 N  N   . LEU   A 1 505 ? -21.243 -81.206  -18.462 1.00 63.67  ? 506  LEU   A N   1 
ATOM   3990 C  CA  . LEU   A 1 505 ? -20.764 -80.248  -19.497 1.00 64.69  ? 506  LEU   A CA  1 
ATOM   3991 C  C   . LEU   A 1 505 ? -21.996 -79.684  -20.209 1.00 65.49  ? 506  LEU   A C   1 
ATOM   3992 O  O   . LEU   A 1 505 ? -22.714 -80.473  -20.845 1.00 67.22  ? 506  LEU   A O   1 
ATOM   3993 C  CB  . LEU   A 1 505 ? -19.839 -80.945  -20.506 1.00 64.15  ? 506  LEU   A CB  1 
ATOM   3994 C  CG  . LEU   A 1 505 ? -18.614 -81.673  -19.953 1.00 61.04  ? 506  LEU   A CG  1 
ATOM   3995 C  CD1 . LEU   A 1 505 ? -17.906 -82.434  -21.063 1.00 60.94  ? 506  LEU   A CD1 1 
ATOM   3996 C  CD2 . LEU   A 1 505 ? -17.652 -80.712  -19.280 1.00 61.87  ? 506  LEU   A CD2 1 
ATOM   3997 N  N   . HIS   A 1 506 ? -22.236 -78.379  -20.087 1.00 68.79  ? 507  HIS   A N   1 
ATOM   3998 C  CA  . HIS   A 1 506 ? -23.451 -77.697  -20.603 1.00 72.07  ? 507  HIS   A CA  1 
ATOM   3999 C  C   . HIS   A 1 506 ? -23.063 -76.628  -21.631 1.00 71.81  ? 507  HIS   A C   1 
ATOM   4000 O  O   . HIS   A 1 506 ? -23.341 -76.849  -22.823 1.00 77.17  ? 507  HIS   A O   1 
ATOM   4001 C  CB  . HIS   A 1 506 ? -24.264 -77.125  -19.440 1.00 76.53  ? 507  HIS   A CB  1 
ATOM   4002 C  CG  . HIS   A 1 506 ? -25.473 -76.385  -19.891 1.00 81.21  ? 507  HIS   A CG  1 
ATOM   4003 N  ND1 . HIS   A 1 506 ? -26.433 -76.973  -20.691 1.00 81.51  ? 507  HIS   A ND1 1 
ATOM   4004 C  CD2 . HIS   A 1 506 ? -25.878 -75.117  -19.666 1.00 83.78  ? 507  HIS   A CD2 1 
ATOM   4005 C  CE1 . HIS   A 1 506 ? -27.384 -76.099  -20.938 1.00 83.59  ? 507  HIS   A CE1 1 
ATOM   4006 N  NE2 . HIS   A 1 506 ? -27.067 -74.950  -20.319 1.00 85.93  ? 507  HIS   A NE2 1 
ATOM   4007 N  N   . ASN   A 1 507 ? -22.473 -75.512  -21.187 1.00 67.53  ? 508  ASN   A N   1 
ATOM   4008 C  CA  . ASN   A 1 507 ? -21.978 -74.428  -22.079 1.00 69.32  ? 508  ASN   A CA  1 
ATOM   4009 C  C   . ASN   A 1 507 ? -20.563 -74.788  -22.553 1.00 68.03  ? 508  ASN   A C   1 
ATOM   4010 O  O   . ASN   A 1 507 ? -19.581 -74.431  -21.858 1.00 65.60  ? 508  ASN   A O   1 
ATOM   4011 C  CB  . ASN   A 1 507 ? -22.024 -73.051  -21.407 1.00 68.05  ? 508  ASN   A CB  1 
ATOM   4012 C  CG  . ASN   A 1 507 ? -21.659 -71.931  -22.359 1.00 67.44  ? 508  ASN   A CG  1 
ATOM   4013 O  OD1 . ASN   A 1 507 ? -21.690 -72.108  -23.576 1.00 71.07  ? 508  ASN   A OD1 1 
ATOM   4014 N  ND2 . ASN   A 1 507 ? -21.311 -70.774  -21.823 1.00 69.18  ? 508  ASN   A ND2 1 
ATOM   4015 N  N   . PHE   A 1 508 ? -20.461 -75.477  -23.692 1.00 63.24  ? 509  PHE   A N   1 
ATOM   4016 C  CA  . PHE   A 1 508 ? -19.178 -75.961  -24.263 1.00 63.96  ? 509  PHE   A CA  1 
ATOM   4017 C  C   . PHE   A 1 508 ? -19.377 -76.320  -25.739 1.00 63.94  ? 509  PHE   A C   1 
ATOM   4018 O  O   . PHE   A 1 508 ? -20.521 -76.281  -26.238 1.00 65.48  ? 509  PHE   A O   1 
ATOM   4019 C  CB  . PHE   A 1 508 ? -18.636 -77.146  -23.448 1.00 61.34  ? 509  PHE   A CB  1 
ATOM   4020 C  CG  . PHE   A 1 508 ? -19.249 -78.485  -23.777 1.00 57.20  ? 509  PHE   A CG  1 
ATOM   4021 C  CD1 . PHE   A 1 508 ? -20.569 -78.760  -23.459 1.00 56.45  ? 509  PHE   A CD1 1 
ATOM   4022 C  CD2 . PHE   A 1 508 ? -18.507 -79.468  -24.414 1.00 56.29  ? 509  PHE   A CD2 1 
ATOM   4023 C  CE1 . PHE   A 1 508 ? -21.136 -79.986  -23.775 1.00 56.83  ? 509  PHE   A CE1 1 
ATOM   4024 C  CE2 . PHE   A 1 508 ? -19.074 -80.694  -24.728 1.00 57.46  ? 509  PHE   A CE2 1 
ATOM   4025 C  CZ  . PHE   A 1 508 ? -20.390 -80.951  -24.413 1.00 56.23  ? 509  PHE   A CZ  1 
ATOM   4026 N  N   . HIS   A 1 509 ? -18.277 -76.677  -26.403 1.00 62.63  ? 510  HIS   A N   1 
ATOM   4027 C  CA  . HIS   A 1 509 ? -18.222 -77.081  -27.830 1.00 64.47  ? 510  HIS   A CA  1 
ATOM   4028 C  C   . HIS   A 1 509 ? -17.305 -78.306  -27.960 1.00 65.51  ? 510  HIS   A C   1 
ATOM   4029 O  O   . HIS   A 1 509 ? -16.145 -78.211  -27.529 1.00 66.75  ? 510  HIS   A O   1 
ATOM   4030 C  CB  . HIS   A 1 509 ? -17.767 -75.872  -28.662 1.00 63.04  ? 510  HIS   A CB  1 
ATOM   4031 C  CG  . HIS   A 1 509 ? -17.831 -76.079  -30.136 1.00 63.80  ? 510  HIS   A CG  1 
ATOM   4032 N  ND1 . HIS   A 1 509 ? -17.030 -75.369  -31.010 1.00 66.60  ? 510  HIS   A ND1 1 
ATOM   4033 C  CD2 . HIS   A 1 509 ? -18.573 -76.919  -30.891 1.00 63.38  ? 510  HIS   A CD2 1 
ATOM   4034 C  CE1 . HIS   A 1 509 ? -17.287 -75.754  -32.244 1.00 67.06  ? 510  HIS   A CE1 1 
ATOM   4035 N  NE2 . HIS   A 1 509 ? -18.232 -76.707  -32.197 1.00 63.02  ? 510  HIS   A NE2 1 
ATOM   4036 N  N   . GLN   A 1 510 ? -17.812 -79.420  -28.495 1.00 64.38  ? 511  GLN   A N   1 
ATOM   4037 C  CA  . GLN   A 1 510 ? -16.996 -80.620  -28.821 1.00 65.59  ? 511  GLN   A CA  1 
ATOM   4038 C  C   . GLN   A 1 510 ? -16.308 -80.393  -30.170 1.00 63.09  ? 511  GLN   A C   1 
ATOM   4039 O  O   . GLN   A 1 510 ? -17.015 -80.280  -31.187 1.00 62.66  ? 511  GLN   A O   1 
ATOM   4040 C  CB  . GLN   A 1 510 ? -17.860 -81.881  -28.848 1.00 70.13  ? 511  GLN   A CB  1 
ATOM   4041 C  CG  . GLN   A 1 510 ? -17.050 -83.169  -28.878 1.00 71.42  ? 511  GLN   A CG  1 
ATOM   4042 C  CD  . GLN   A 1 510 ? -17.785 -84.309  -28.215 1.00 75.17  ? 511  GLN   A CD  1 
ATOM   4043 O  OE1 . GLN   A 1 510 ? -17.890 -84.381  -26.989 1.00 78.44  ? 511  GLN   A OE1 1 
ATOM   4044 N  NE2 . GLN   A 1 510 ? -18.311 -85.211  -29.028 1.00 74.85  ? 511  GLN   A NE2 1 
ATOM   4045 N  N   . LEU   A 1 511 ? -14.976 -80.334  -30.172 1.00 62.26  ? 512  LEU   A N   1 
ATOM   4046 C  CA  . LEU   A 1 511 ? -14.162 -79.920  -31.348 1.00 58.94  ? 512  LEU   A CA  1 
ATOM   4047 C  C   . LEU   A 1 511 ? -13.936 -81.105  -32.294 1.00 55.89  ? 512  LEU   A C   1 
ATOM   4048 O  O   . LEU   A 1 511 ? -13.570 -80.849  -33.455 1.00 56.56  ? 512  LEU   A O   1 
ATOM   4049 C  CB  . LEU   A 1 511 ? -12.832 -79.342  -30.854 1.00 57.23  ? 512  LEU   A CB  1 
ATOM   4050 C  CG  . LEU   A 1 511 ? -12.960 -78.149  -29.908 1.00 58.66  ? 512  LEU   A CG  1 
ATOM   4051 C  CD1 . LEU   A 1 511 ? -11.595 -77.604  -29.522 1.00 57.58  ? 512  LEU   A CD1 1 
ATOM   4052 C  CD2 . LEU   A 1 511 ? -13.819 -77.054  -30.527 1.00 59.41  ? 512  LEU   A CD2 1 
ATOM   4053 N  N   . SER   A 1 512 ? -14.134 -82.344  -31.830 1.00 53.26  ? 513  SER   A N   1 
ATOM   4054 C  CA  . SER   A 1 512 ? -13.815 -83.575  -32.604 1.00 53.31  ? 513  SER   A CA  1 
ATOM   4055 C  C   . SER   A 1 512 ? -14.567 -84.773  -32.017 1.00 55.47  ? 513  SER   A C   1 
ATOM   4056 O  O   . SER   A 1 512 ? -14.795 -84.779  -30.801 1.00 61.80  ? 513  SER   A O   1 
ATOM   4057 C  CB  . SER   A 1 512 ? -12.320 -83.805  -32.622 1.00 51.64  ? 513  SER   A CB  1 
ATOM   4058 O  OG  . SER   A 1 512 ? -11.931 -84.601  -33.729 1.00 50.42  ? 513  SER   A OG  1 
ATOM   4059 N  N   . ALA   A 1 513 ? -14.930 -85.749  -32.852 1.00 57.33  ? 514  ALA   A N   1 
ATOM   4060 C  CA  . ALA   A 1 513 ? -15.651 -86.979  -32.445 1.00 59.16  ? 514  ALA   A CA  1 
ATOM   4061 C  C   . ALA   A 1 513 ? -14.841 -87.695  -31.365 1.00 61.07  ? 514  ALA   A C   1 
ATOM   4062 O  O   . ALA   A 1 513 ? -13.622 -87.810  -31.479 1.00 60.01  ? 514  ALA   A O   1 
ATOM   4063 C  CB  . ALA   A 1 513 ? -15.883 -87.878  -33.637 1.00 56.43  ? 514  ALA   A CB  1 
ATOM   4064 N  N   . PRO   A 1 514 ? -15.484 -88.184  -30.280 1.00 60.10  ? 515  PRO   A N   1 
ATOM   4065 C  CA  . PRO   A 1 514 ? -14.795 -88.984  -29.270 1.00 59.54  ? 515  PRO   A CA  1 
ATOM   4066 C  C   . PRO   A 1 514 ? -14.016 -90.142  -29.901 1.00 60.91  ? 515  PRO   A C   1 
ATOM   4067 O  O   . PRO   A 1 514 ? -14.501 -90.713  -30.856 1.00 65.73  ? 515  PRO   A O   1 
ATOM   4068 C  CB  . PRO   A 1 514 ? -15.935 -89.503  -28.384 1.00 59.69  ? 515  PRO   A CB  1 
ATOM   4069 C  CG  . PRO   A 1 514 ? -16.996 -88.433  -28.506 1.00 61.85  ? 515  PRO   A CG  1 
ATOM   4070 C  CD  . PRO   A 1 514 ? -16.895 -87.957  -29.942 1.00 62.55  ? 515  PRO   A CD  1 
ATOM   4071 N  N   . GLN   A 1 515 ? -12.827 -90.430  -29.368 1.00 59.78  ? 516  GLN   A N   1 
ATOM   4072 C  CA  . GLN   A 1 515 ? -11.959 -91.553  -29.805 1.00 58.32  ? 516  GLN   A CA  1 
ATOM   4073 C  C   . GLN   A 1 515 ? -11.593 -92.392  -28.587 1.00 58.63  ? 516  GLN   A C   1 
ATOM   4074 O  O   . GLN   A 1 515 ? -11.413 -91.857  -27.496 1.00 57.39  ? 516  GLN   A O   1 
ATOM   4075 C  CB  . GLN   A 1 515 ? -10.702 -91.023  -30.495 1.00 59.22  ? 516  GLN   A CB  1 
ATOM   4076 C  CG  . GLN   A 1 515 ? -10.959 -90.478  -31.893 1.00 60.15  ? 516  GLN   A CG  1 
ATOM   4077 C  CD  . GLN   A 1 515 ? -9.678  -90.131  -32.615 1.00 61.52  ? 516  GLN   A CD  1 
ATOM   4078 O  OE1 . GLN   A 1 515 ? -8.706  -90.887  -32.592 1.00 59.43  ? 516  GLN   A OE1 1 
ATOM   4079 N  NE2 . GLN   A 1 515 ? -9.666  -88.975  -33.262 1.00 61.71  ? 516  GLN   A NE2 1 
ATOM   4080 N  N   . PRO   A 1 516 ? -11.443 -93.726  -28.741 1.00 58.34  ? 517  PRO   A N   1 
ATOM   4081 C  CA  . PRO   A 1 516 ? -11.131 -94.595  -27.610 1.00 57.62  ? 517  PRO   A CA  1 
ATOM   4082 C  C   . PRO   A 1 516 ? -9.743  -94.244  -27.066 1.00 56.33  ? 517  PRO   A C   1 
ATOM   4083 O  O   . PRO   A 1 516 ? -8.885  -93.903  -27.860 1.00 55.29  ? 517  PRO   A O   1 
ATOM   4084 C  CB  . PRO   A 1 516 ? -11.154 -96.007  -28.212 1.00 58.33  ? 517  PRO   A CB  1 
ATOM   4085 C  CG  . PRO   A 1 516 ? -10.808 -95.776  -29.666 1.00 58.47  ? 517  PRO   A CG  1 
ATOM   4086 C  CD  . PRO   A 1 516 ? -11.480 -94.462  -30.013 1.00 57.81  ? 517  PRO   A CD  1 
ATOM   4087 N  N   . CYS   A 1 517 ? -9.576  -94.325  -25.744 1.00 55.07  ? 518  CYS   A N   1 
ATOM   4088 C  CA  . CYS   A 1 517 ? -8.327  -93.984  -25.018 1.00 54.42  ? 518  CYS   A CA  1 
ATOM   4089 C  C   . CYS   A 1 517 ? -7.731  -95.263  -24.413 1.00 53.21  ? 518  CYS   A C   1 
ATOM   4090 O  O   . CYS   A 1 517 ? -6.777  -95.795  -25.004 1.00 51.86  ? 518  CYS   A O   1 
ATOM   4091 C  CB  . CYS   A 1 517 ? -8.589  -92.908  -23.969 1.00 54.17  ? 518  CYS   A CB  1 
ATOM   4092 S  SG  . CYS   A 1 517 ? -7.105  -92.414  -23.054 1.00 54.12  ? 518  CYS   A SG  1 
ATOM   4093 N  N   . PHE   A 1 518 ? -8.284  -95.750  -23.297 1.00 55.15  ? 519  PHE   A N   1 
ATOM   4094 C  CA  . PHE   A 1 518 ? -7.801  -96.953  -22.569 1.00 53.23  ? 519  PHE   A CA  1 
ATOM   4095 C  C   . PHE   A 1 518 ? -8.894  -98.026  -22.569 1.00 52.29  ? 519  PHE   A C   1 
ATOM   4096 O  O   . PHE   A 1 518 ? -10.080 -97.682  -22.385 1.00 49.88  ? 519  PHE   A O   1 
ATOM   4097 C  CB  . PHE   A 1 518 ? -7.383  -96.591  -21.141 1.00 54.10  ? 519  PHE   A CB  1 
ATOM   4098 C  CG  . PHE   A 1 518 ? -6.287  -95.560  -21.030 1.00 54.16  ? 519  PHE   A CG  1 
ATOM   4099 C  CD1 . PHE   A 1 518 ? -5.218  -95.551  -21.914 1.00 55.75  ? 519  PHE   A CD1 1 
ATOM   4100 C  CD2 . PHE   A 1 518 ? -6.312  -94.611  -20.020 1.00 54.34  ? 519  PHE   A CD2 1 
ATOM   4101 C  CE1 . PHE   A 1 518 ? -4.213  -94.602  -21.805 1.00 55.57  ? 519  PHE   A CE1 1 
ATOM   4102 C  CE2 . PHE   A 1 518 ? -5.302  -93.669  -19.907 1.00 55.24  ? 519  PHE   A CE2 1 
ATOM   4103 C  CZ  . PHE   A 1 518 ? -4.254  -93.667  -20.798 1.00 56.03  ? 519  PHE   A CZ  1 
ATOM   4104 N  N   . THR   A 1 519 ? -8.489  -99.284  -22.772 1.00 51.46  ? 520  THR   A N   1 
ATOM   4105 C  CA  . THR   A 1 519 ? -9.368  -100.484 -22.774 1.00 52.38  ? 520  THR   A CA  1 
ATOM   4106 C  C   . THR   A 1 519 ? -8.811  -101.526 -21.799 1.00 50.87  ? 520  THR   A C   1 
ATOM   4107 O  O   . THR   A 1 519 ? -7.574  -101.731 -21.787 1.00 47.44  ? 520  THR   A O   1 
ATOM   4108 C  CB  . THR   A 1 519 ? -9.494  -101.060 -24.191 1.00 54.19  ? 520  THR   A CB  1 
ATOM   4109 O  OG1 . THR   A 1 519 ? -10.142 -100.075 -24.996 1.00 58.63  ? 520  THR   A OG1 1 
ATOM   4110 C  CG2 . THR   A 1 519 ? -10.279 -102.352 -24.253 1.00 53.51  ? 520  THR   A CG2 1 
ATOM   4111 N  N   . PHE   A 1 520 ? -9.695  -102.173 -21.036 1.00 50.61  ? 521  PHE   A N   1 
ATOM   4112 C  CA  . PHE   A 1 520 ? -9.361  -103.286 -20.108 1.00 52.80  ? 521  PHE   A CA  1 
ATOM   4113 C  C   . PHE   A 1 520 ? -10.293 -104.470 -20.376 1.00 53.01  ? 521  PHE   A C   1 
ATOM   4114 O  O   . PHE   A 1 520 ? -11.486 -104.238 -20.640 1.00 53.99  ? 521  PHE   A O   1 
ATOM   4115 C  CB  . PHE   A 1 520 ? -9.446  -102.812 -18.656 1.00 54.10  ? 521  PHE   A CB  1 
ATOM   4116 C  CG  . PHE   A 1 520 ? -8.361  -101.838 -18.282 1.00 55.05  ? 521  PHE   A CG  1 
ATOM   4117 C  CD1 . PHE   A 1 520 ? -7.130  -102.295 -17.840 1.00 55.21  ? 521  PHE   A CD1 1 
ATOM   4118 C  CD2 . PHE   A 1 520 ? -8.557  -100.470 -18.410 1.00 55.86  ? 521  PHE   A CD2 1 
ATOM   4119 C  CE1 . PHE   A 1 520 ? -6.121  -101.402 -17.520 1.00 59.25  ? 521  PHE   A CE1 1 
ATOM   4120 C  CE2 . PHE   A 1 520 ? -7.544  -99.578  -18.097 1.00 56.53  ? 521  PHE   A CE2 1 
ATOM   4121 C  CZ  . PHE   A 1 520 ? -6.328  -100.045 -17.652 1.00 58.93  ? 521  PHE   A CZ  1 
ATOM   4122 N  N   . SER   A 1 521 ? -9.749  -105.689 -20.299 1.00 55.85  ? 522  SER   A N   1 
ATOM   4123 C  CA  . SER   A 1 521 ? -10.467 -106.977 -20.500 1.00 58.96  ? 522  SER   A CA  1 
ATOM   4124 C  C   . SER   A 1 521 ? -10.409 -107.810 -19.217 1.00 60.64  ? 522  SER   A C   1 
ATOM   4125 O  O   . SER   A 1 521 ? -9.344  -107.815 -18.554 1.00 62.40  ? 522  SER   A O   1 
ATOM   4126 C  CB  . SER   A 1 521 ? -9.893  -107.737 -21.667 1.00 58.54  ? 522  SER   A CB  1 
ATOM   4127 O  OG  . SER   A 1 521 ? -10.574 -107.397 -22.863 1.00 61.12  ? 522  SER   A OG  1 
ATOM   4128 N  N   . HIS   A 1 522 ? -11.510 -108.496 -18.896 1.00 63.21  ? 523  HIS   A N   1 
ATOM   4129 C  CA  . HIS   A 1 522 ? -11.673 -109.318 -17.666 1.00 67.12  ? 523  HIS   A CA  1 
ATOM   4130 C  C   . HIS   A 1 522 ? -12.346 -110.645 -18.020 1.00 66.67  ? 523  HIS   A C   1 
ATOM   4131 O  O   . HIS   A 1 522 ? -13.414 -110.658 -18.624 1.00 64.61  ? 523  HIS   A O   1 
ATOM   4132 C  CB  . HIS   A 1 522 ? -12.407 -108.503 -16.589 1.00 67.09  ? 523  HIS   A CB  1 
ATOM   4133 C  CG  . HIS   A 1 522 ? -11.627 -107.306 -16.156 1.00 67.63  ? 523  HIS   A CG  1 
ATOM   4134 N  ND1 . HIS   A 1 522 ? -10.343 -107.413 -15.656 1.00 66.73  ? 523  HIS   A ND1 1 
ATOM   4135 C  CD2 . HIS   A 1 522 ? -11.917 -105.987 -16.176 1.00 67.04  ? 523  HIS   A CD2 1 
ATOM   4136 C  CE1 . HIS   A 1 522 ? -9.883  -106.212 -15.371 1.00 66.23  ? 523  HIS   A CE1 1 
ATOM   4137 N  NE2 . HIS   A 1 522 ? -10.827 -105.321 -15.683 1.00 65.14  ? 523  HIS   A NE2 1 
ATOM   4138 N  N   . PRO   A 1 523 ? -11.746 -111.806 -17.670 1.00 71.04  ? 524  PRO   A N   1 
ATOM   4139 C  CA  . PRO   A 1 523 ? -10.454 -111.857 -16.985 1.00 73.21  ? 524  PRO   A CA  1 
ATOM   4140 C  C   . PRO   A 1 523 ? -9.286  -111.453 -17.897 1.00 76.68  ? 524  PRO   A C   1 
ATOM   4141 O  O   . PRO   A 1 523 ? -9.406  -111.572 -19.103 1.00 76.52  ? 524  PRO   A O   1 
ATOM   4142 C  CB  . PRO   A 1 523 ? -10.315 -113.330 -16.573 1.00 72.20  ? 524  PRO   A CB  1 
ATOM   4143 C  CG  . PRO   A 1 523 ? -11.143 -114.078 -17.596 1.00 71.70  ? 524  PRO   A CG  1 
ATOM   4144 C  CD  . PRO   A 1 523 ? -12.296 -113.147 -17.920 1.00 73.49  ? 524  PRO   A CD  1 
ATOM   4145 N  N   . ASN   A 1 524 ? -8.203  -110.970 -17.287 1.00 84.32  ? 525  ASN   A N   1 
ATOM   4146 C  CA  . ASN   A 1 524 ? -6.923  -110.623 -17.955 1.00 91.67  ? 525  ASN   A CA  1 
ATOM   4147 C  C   . ASN   A 1 524 ? -5.991  -111.836 -17.843 1.00 94.39  ? 525  ASN   A C   1 
ATOM   4148 O  O   . ASN   A 1 524 ? -5.152  -111.856 -16.922 1.00 91.64  ? 525  ASN   A O   1 
ATOM   4149 C  CB  . ASN   A 1 524 ? -6.325  -109.341 -17.362 1.00 94.97  ? 525  ASN   A CB  1 
ATOM   4150 C  CG  . ASN   A 1 524 ? -5.130  -108.815 -18.133 1.00 95.11  ? 525  ASN   A CG  1 
ATOM   4151 O  OD1 . ASN   A 1 524 ? -4.844  -109.275 -19.235 1.00 97.62  ? 525  ASN   A OD1 1 
ATOM   4152 N  ND2 . ASN   A 1 524 ? -4.437  -107.838 -17.571 1.00 92.59  ? 525  ASN   A ND2 1 
ATOM   4153 N  N   . ARG   A 1 525 ? -6.158  -112.813 -18.742 1.00 105.09 ? 526  ARG   A N   1 
ATOM   4154 C  CA  . ARG   A 1 525 ? -5.378  -114.083 -18.787 1.00 111.94 ? 526  ARG   A CA  1 
ATOM   4155 C  C   . ARG   A 1 525 ? -3.896  -113.758 -19.017 1.00 116.57 ? 526  ARG   A C   1 
ATOM   4156 O  O   . ARG   A 1 525 ? -3.043  -114.521 -18.516 1.00 114.10 ? 526  ARG   A O   1 
ATOM   4157 C  CB  . ARG   A 1 525 ? -5.922  -115.012 -19.879 1.00 112.03 ? 526  ARG   A CB  1 
ATOM   4158 C  CG  . ARG   A 1 525 ? -7.335  -115.518 -19.623 1.00 114.15 ? 526  ARG   A CG  1 
ATOM   4159 C  CD  . ARG   A 1 525 ? -7.981  -116.148 -20.844 1.00 114.58 ? 526  ARG   A CD  1 
ATOM   4160 N  NE  . ARG   A 1 525 ? -9.436  -116.218 -20.726 1.00 117.26 ? 526  ARG   A NE  1 
ATOM   4161 C  CZ  . ARG   A 1 525 ? -10.303 -115.327 -21.218 1.00 119.65 ? 526  ARG   A CZ  1 
ATOM   4162 N  NH1 . ARG   A 1 525 ? -9.884  -114.264 -21.887 1.00 120.76 ? 526  ARG   A NH1 1 
ATOM   4163 N  NH2 . ARG   A 1 525 ? -11.601 -115.507 -21.039 1.00 115.37 ? 526  ARG   A NH2 1 
ATOM   4164 N  N   . ASP   A 1 526 ? -3.623  -112.670 -19.750 1.00 120.68 ? 527  ASP   A N   1 
ATOM   4165 C  CA  . ASP   A 1 526 ? -2.279  -112.077 -20.005 1.00 125.25 ? 527  ASP   A CA  1 
ATOM   4166 C  C   . ASP   A 1 526 ? -1.352  -112.345 -18.820 1.00 126.46 ? 527  ASP   A C   1 
ATOM   4167 O  O   . ASP   A 1 526 ? -1.682  -112.002 -17.687 1.00 128.35 ? 527  ASP   A O   1 
ATOM   4168 C  CB  . ASP   A 1 526 ? -2.407  -110.569 -20.254 1.00 127.97 ? 527  ASP   A CB  1 
ATOM   4169 C  CG  . ASP   A 1 526 ? -1.146  -109.871 -20.734 1.00 128.27 ? 527  ASP   A CG  1 
ATOM   4170 O  OD1 . ASP   A 1 526 ? -0.409  -110.472 -21.540 1.00 133.10 ? 527  ASP   A OD1 1 
ATOM   4171 O  OD2 . ASP   A 1 526 ? -0.920  -108.719 -20.306 1.00 121.74 ? 527  ASP   A OD2 1 
ATOM   4172 N  N   . PRO   A 1 527 ? -0.165  -112.960 -19.036 1.00 129.07 ? 528  PRO   A N   1 
ATOM   4173 C  CA  . PRO   A 1 527 ? 0.811   -113.144 -17.963 1.00 128.95 ? 528  PRO   A CA  1 
ATOM   4174 C  C   . PRO   A 1 527 ? 1.557   -111.831 -17.693 1.00 132.89 ? 528  PRO   A C   1 
ATOM   4175 O  O   . PRO   A 1 527 ? 1.681   -111.043 -18.616 1.00 138.17 ? 528  PRO   A O   1 
ATOM   4176 C  CB  . PRO   A 1 527 ? 1.758   -114.207 -18.535 1.00 129.90 ? 528  PRO   A CB  1 
ATOM   4177 C  CG  . PRO   A 1 527 ? 1.742   -113.930 -20.024 1.00 130.78 ? 528  PRO   A CG  1 
ATOM   4178 C  CD  . PRO   A 1 527 ? 0.321   -113.490 -20.322 1.00 131.29 ? 528  PRO   A CD  1 
ATOM   4179 N  N   . MET   A 1 528 ? 2.029   -111.633 -16.458 1.00 131.56 ? 529  MET   A N   1 
ATOM   4180 C  CA  . MET   A 1 528 ? 2.788   -110.422 -16.040 1.00 130.74 ? 529  MET   A CA  1 
ATOM   4181 C  C   . MET   A 1 528 ? 1.929   -109.180 -16.326 1.00 120.16 ? 529  MET   A C   1 
ATOM   4182 O  O   . MET   A 1 528 ? 2.413   -108.260 -17.020 1.00 117.68 ? 529  MET   A O   1 
ATOM   4183 C  CB  . MET   A 1 528 ? 4.121   -110.334 -16.793 1.00 138.24 ? 529  MET   A CB  1 
ATOM   4184 C  CG  . MET   A 1 528 ? 4.901   -111.643 -16.808 1.00 142.51 ? 529  MET   A CG  1 
ATOM   4185 S  SD  . MET   A 1 528 ? 6.165   -111.719 -18.107 1.00 150.79 ? 529  MET   A SD  1 
ATOM   4186 C  CE  . MET   A 1 528 ? 5.153   -111.666 -19.587 1.00 148.19 ? 529  MET   A CE  1 
ATOM   4187 N  N   . ILE   A 1 529 ? 0.697   -109.178 -15.802 1.00 107.84 ? 530  ILE   A N   1 
ATOM   4188 C  CA  . ILE   A 1 529 ? -0.350  -108.128 -16.007 1.00 98.25  ? 530  ILE   A CA  1 
ATOM   4189 C  C   . ILE   A 1 529 ? 0.271   -106.744 -15.782 1.00 88.90  ? 530  ILE   A C   1 
ATOM   4190 O  O   . ILE   A 1 529 ? 0.979   -106.583 -14.770 1.00 86.45  ? 530  ILE   A O   1 
ATOM   4191 C  CB  . ILE   A 1 529 ? -1.542  -108.362 -15.055 1.00 100.03 ? 530  ILE   A CB  1 
ATOM   4192 C  CG1 . ILE   A 1 529 ? -2.287  -109.665 -15.364 1.00 101.51 ? 530  ILE   A CG1 1 
ATOM   4193 C  CG2 . ILE   A 1 529 ? -2.482  -107.165 -15.063 1.00 102.64 ? 530  ILE   A CG2 1 
ATOM   4194 C  CD1 . ILE   A 1 529 ? -3.120  -110.183 -14.211 1.00 100.13 ? 530  ILE   A CD1 1 
ATOM   4195 N  N   . ASP   A 1 530 ? 0.001   -105.787 -16.679 1.00 78.32  ? 531  ASP   A N   1 
ATOM   4196 C  CA  . ASP   A 1 530 ? 0.397   -104.359 -16.525 1.00 74.01  ? 531  ASP   A CA  1 
ATOM   4197 C  C   . ASP   A 1 530 ? -0.771  -103.451 -16.936 1.00 65.59  ? 531  ASP   A C   1 
ATOM   4198 O  O   . ASP   A 1 530 ? -1.129  -103.440 -18.127 1.00 64.50  ? 531  ASP   A O   1 
ATOM   4199 C  CB  . ASP   A 1 530 ? 1.662   -104.040 -17.323 1.00 75.47  ? 531  ASP   A CB  1 
ATOM   4200 C  CG  . ASP   A 1 530 ? 2.264   -102.686 -16.987 1.00 77.20  ? 531  ASP   A CG  1 
ATOM   4201 O  OD1 . ASP   A 1 530 ? 1.606   -101.920 -16.253 1.00 75.76  ? 531  ASP   A OD1 1 
ATOM   4202 O  OD2 . ASP   A 1 530 ? 3.394   -102.413 -17.450 1.00 76.59  ? 531  ASP   A OD2 1 
ATOM   4203 N  N   . ASN   A 1 531 ? -1.319  -102.697 -15.980 1.00 59.40  ? 532  ASN   A N   1 
ATOM   4204 C  CA  . ASN   A 1 531 ? -2.519  -101.836 -16.163 1.00 57.25  ? 532  ASN   A CA  1 
ATOM   4205 C  C   . ASN   A 1 531 ? -2.112  -100.400 -16.512 1.00 54.43  ? 532  ASN   A C   1 
ATOM   4206 O  O   . ASN   A 1 531 ? -3.019  -99.608  -16.820 1.00 51.82  ? 532  ASN   A O   1 
ATOM   4207 C  CB  . ASN   A 1 531 ? -3.411  -101.853 -14.922 1.00 56.53  ? 532  ASN   A CB  1 
ATOM   4208 C  CG  . ASN   A 1 531 ? -4.163  -103.155 -14.770 1.00 57.95  ? 532  ASN   A CG  1 
ATOM   4209 O  OD1 . ASN   A 1 531 ? -4.488  -103.819 -15.758 1.00 54.91  ? 532  ASN   A OD1 1 
ATOM   4210 N  ND2 . ASN   A 1 531 ? -4.453  -103.520 -13.534 1.00 60.62  ? 532  ASN   A ND2 1 
ATOM   4211 N  N   . ASN   A 1 532 ? -0.813  -100.079 -16.461 1.00 53.04  ? 533  ASN   A N   1 
ATOM   4212 C  CA  . ASN   A 1 532 ? -0.244  -98.808  -16.984 1.00 53.52  ? 533  ASN   A CA  1 
ATOM   4213 C  C   . ASN   A 1 532 ? -0.581  -98.697  -18.475 1.00 56.75  ? 533  ASN   A C   1 
ATOM   4214 O  O   . ASN   A 1 532 ? -0.754  -99.749  -19.132 1.00 58.00  ? 533  ASN   A O   1 
ATOM   4215 C  CB  . ASN   A 1 532 ? 1.269   -98.709  -16.774 1.00 52.74  ? 533  ASN   A CB  1 
ATOM   4216 C  CG  . ASN   A 1 532 ? 1.677   -98.549  -15.324 1.00 53.06  ? 533  ASN   A CG  1 
ATOM   4217 O  OD1 . ASN   A 1 532 ? 0.875   -98.177  -14.470 1.00 51.76  ? 533  ASN   A OD1 1 
ATOM   4218 N  ND2 . ASN   A 1 532 ? 2.939   -98.816  -15.037 1.00 56.69  ? 533  ASN   A ND2 1 
ATOM   4219 N  N   . ARG   A 1 533 ? -0.693  -97.471  -18.990 1.00 58.35  ? 534  ARG   A N   1 
ATOM   4220 C  CA  . ARG   A 1 533 ? -1.059  -97.215  -20.408 1.00 58.59  ? 534  ARG   A CA  1 
ATOM   4221 C  C   . ARG   A 1 533 ? -0.388  -95.932  -20.898 1.00 58.97  ? 534  ARG   A C   1 
ATOM   4222 O  O   . ARG   A 1 533 ? -0.172  -95.021  -20.080 1.00 66.63  ? 534  ARG   A O   1 
ATOM   4223 C  CB  . ARG   A 1 533 ? -2.575  -97.088  -20.569 1.00 59.37  ? 534  ARG   A CB  1 
ATOM   4224 C  CG  . ARG   A 1 533 ? -3.360  -98.367  -20.315 1.00 59.09  ? 534  ARG   A CG  1 
ATOM   4225 C  CD  . ARG   A 1 533 ? -3.193  -99.405  -21.407 1.00 58.44  ? 534  ARG   A CD  1 
ATOM   4226 N  NE  . ARG   A 1 533 ? -4.279  -100.377 -21.354 1.00 57.57  ? 534  ARG   A NE  1 
ATOM   4227 C  CZ  . ARG   A 1 533 ? -4.298  -101.475 -20.594 1.00 56.50  ? 534  ARG   A CZ  1 
ATOM   4228 N  NH1 . ARG   A 1 533 ? -3.274  -101.779 -19.811 1.00 53.98  ? 534  ARG   A NH1 1 
ATOM   4229 N  NH2 . ARG   A 1 533 ? -5.354  -102.270 -20.620 1.00 55.79  ? 534  ARG   A NH2 1 
ATOM   4230 N  N   . TYR   A 1 534 ? -0.057  -95.900  -22.188 1.00 57.58  ? 535  TYR   A N   1 
ATOM   4231 C  CA  . TYR   A 1 534 ? 0.350   -94.700  -22.959 1.00 57.91  ? 535  TYR   A CA  1 
ATOM   4232 C  C   . TYR   A 1 534 ? -0.421  -94.743  -24.280 1.00 58.53  ? 535  TYR   A C   1 
ATOM   4233 O  O   . TYR   A 1 534 ? -0.422  -95.797  -24.927 1.00 59.64  ? 535  TYR   A O   1 
ATOM   4234 C  CB  . TYR   A 1 534 ? 1.870   -94.669  -23.136 1.00 57.89  ? 535  TYR   A CB  1 
ATOM   4235 C  CG  . TYR   A 1 534 ? 2.398   -93.586  -24.046 1.00 60.24  ? 535  TYR   A CG  1 
ATOM   4236 C  CD1 . TYR   A 1 534 ? 1.869   -92.305  -24.026 1.00 61.14  ? 535  TYR   A CD1 1 
ATOM   4237 C  CD2 . TYR   A 1 534 ? 3.450   -93.835  -24.913 1.00 60.90  ? 535  TYR   A CD2 1 
ATOM   4238 C  CE1 . TYR   A 1 534 ? 2.359   -91.308  -24.853 1.00 60.43  ? 535  TYR   A CE1 1 
ATOM   4239 C  CE2 . TYR   A 1 534 ? 3.953   -92.849  -25.745 1.00 61.12  ? 535  TYR   A CE2 1 
ATOM   4240 C  CZ  . TYR   A 1 534 ? 3.406   -91.579  -25.715 1.00 60.73  ? 535  TYR   A CZ  1 
ATOM   4241 O  OH  . TYR   A 1 534 ? 3.897   -90.598  -26.525 1.00 61.11  ? 535  TYR   A OH  1 
ATOM   4242 N  N   . CYS   A 1 535 ? -1.103  -93.653  -24.630 1.00 62.62  ? 536  CYS   A N   1 
ATOM   4243 C  CA  . CYS   A 1 535 ? -2.016  -93.571  -25.799 1.00 62.71  ? 536  CYS   A CA  1 
ATOM   4244 C  C   . CYS   A 1 535 ? -1.924  -92.179  -26.428 1.00 62.03  ? 536  CYS   A C   1 
ATOM   4245 O  O   . CYS   A 1 535 ? -2.192  -91.194  -25.712 1.00 61.08  ? 536  CYS   A O   1 
ATOM   4246 C  CB  . CYS   A 1 535 ? -3.451  -93.860  -25.382 1.00 64.49  ? 536  CYS   A CB  1 
ATOM   4247 S  SG  . CYS   A 1 535 ? -4.669  -93.437  -26.653 1.00 70.46  ? 536  CYS   A SG  1 
ATOM   4248 N  N   . THR   A 1 536 ? -1.564  -92.120  -27.713 1.00 58.85  ? 537  THR   A N   1 
ATOM   4249 C  CA  . THR   A 1 536 ? -1.547  -90.888  -28.544 1.00 58.06  ? 537  THR   A CA  1 
ATOM   4250 C  C   . THR   A 1 536 ? -2.853  -90.809  -29.347 1.00 56.05  ? 537  THR   A C   1 
ATOM   4251 O  O   . THR   A 1 536 ? -3.166  -91.784  -30.042 1.00 57.58  ? 537  THR   A O   1 
ATOM   4252 C  CB  . THR   A 1 536 ? -0.307  -90.871  -29.444 1.00 57.18  ? 537  THR   A CB  1 
ATOM   4253 O  OG1 . THR   A 1 536 ? 0.838   -91.027  -28.605 1.00 58.25  ? 537  THR   A OG1 1 
ATOM   4254 C  CG2 . THR   A 1 536 ? -0.181  -89.600  -30.253 1.00 59.07  ? 537  THR   A CG2 1 
ATOM   4255 N  N   . LEU   A 1 537 ? -3.590  -89.699  -29.246 1.00 54.81  ? 538  LEU   A N   1 
ATOM   4256 C  CA  . LEU   A 1 537 ? -4.830  -89.458  -30.035 1.00 55.32  ? 538  LEU   A CA  1 
ATOM   4257 C  C   . LEU   A 1 537 ? -4.646  -88.211  -30.903 1.00 55.04  ? 538  LEU   A C   1 
ATOM   4258 O  O   . LEU   A 1 537 ? -4.109  -87.201  -30.396 1.00 53.07  ? 538  LEU   A O   1 
ATOM   4259 C  CB  . LEU   A 1 537 ? -6.031  -89.296  -29.098 1.00 55.96  ? 538  LEU   A CB  1 
ATOM   4260 C  CG  . LEU   A 1 537 ? -6.334  -90.492  -28.198 1.00 59.63  ? 538  LEU   A CG  1 
ATOM   4261 C  CD1 . LEU   A 1 537 ? -7.443  -90.156  -27.217 1.00 61.32  ? 538  LEU   A CD1 1 
ATOM   4262 C  CD2 . LEU   A 1 537 ? -6.703  -91.723  -29.015 1.00 62.39  ? 538  LEU   A CD2 1 
ATOM   4263 N  N   . GLU   A 1 538 ? -5.079  -88.303  -32.163 1.00 56.33  ? 539  GLU   A N   1 
ATOM   4264 C  CA  . GLU   A 1 538 ? -5.046  -87.199  -33.157 1.00 59.99  ? 539  GLU   A CA  1 
ATOM   4265 C  C   . GLU   A 1 538 ? -6.487  -86.856  -33.537 1.00 58.03  ? 539  GLU   A C   1 
ATOM   4266 O  O   . GLU   A 1 538 ? -7.185  -87.729  -34.093 1.00 59.91  ? 539  GLU   A O   1 
ATOM   4267 C  CB  . GLU   A 1 538 ? -4.179  -87.585  -34.356 1.00 62.66  ? 539  GLU   A CB  1 
ATOM   4268 C  CG  . GLU   A 1 538 ? -2.696  -87.523  -34.043 1.00 65.34  ? 539  GLU   A CG  1 
ATOM   4269 C  CD  . GLU   A 1 538 ? -1.794  -87.631  -35.255 1.00 68.47  ? 539  GLU   A CD  1 
ATOM   4270 O  OE1 . GLU   A 1 538 ? -1.422  -88.763  -35.605 1.00 75.47  ? 539  GLU   A OE1 1 
ATOM   4271 O  OE2 . GLU   A 1 538 ? -1.474  -86.582  -35.845 1.00 71.38  ? 539  GLU   A OE2 1 
ATOM   4272 N  N   . PHE   A 1 539 ? -6.900  -85.631  -33.209 1.00 56.56  ? 540  PHE   A N   1 
ATOM   4273 C  CA  . PHE   A 1 539 ? -8.281  -85.110  -33.342 1.00 55.87  ? 540  PHE   A CA  1 
ATOM   4274 C  C   . PHE   A 1 539 ? -8.335  -84.085  -34.468 1.00 57.58  ? 540  PHE   A C   1 
ATOM   4275 O  O   . PHE   A 1 539 ? -7.889  -82.956  -34.283 1.00 56.07  ? 540  PHE   A O   1 
ATOM   4276 C  CB  . PHE   A 1 539 ? -8.720  -84.480  -32.021 1.00 56.66  ? 540  PHE   A CB  1 
ATOM   4277 C  CG  . PHE   A 1 539 ? -9.001  -85.471  -30.922 1.00 56.70  ? 540  PHE   A CG  1 
ATOM   4278 C  CD1 . PHE   A 1 539 ? -10.092 -86.320  -31.002 1.00 55.82  ? 540  PHE   A CD1 1 
ATOM   4279 C  CD2 . PHE   A 1 539 ? -8.193  -85.538  -29.798 1.00 56.81  ? 540  PHE   A CD2 1 
ATOM   4280 C  CE1 . PHE   A 1 539 ? -10.362 -87.225  -29.989 1.00 56.34  ? 540  PHE   A CE1 1 
ATOM   4281 C  CE2 . PHE   A 1 539 ? -8.466  -86.444  -28.785 1.00 56.69  ? 540  PHE   A CE2 1 
ATOM   4282 C  CZ  . PHE   A 1 539 ? -9.547  -87.286  -28.883 1.00 56.89  ? 540  PHE   A CZ  1 
ATOM   4283 N  N   . PRO   A 1 540 ? -8.866  -84.436  -35.664 1.00 62.86  ? 541  PRO   A N   1 
ATOM   4284 C  CA  . PRO   A 1 540 ? -9.028  -83.463  -36.743 1.00 65.17  ? 541  PRO   A CA  1 
ATOM   4285 C  C   . PRO   A 1 540 ? -10.060 -82.400  -36.347 1.00 66.89  ? 541  PRO   A C   1 
ATOM   4286 O  O   . PRO   A 1 540 ? -11.174 -82.767  -36.010 1.00 71.94  ? 541  PRO   A O   1 
ATOM   4287 C  CB  . PRO   A 1 540 ? -9.496  -84.298  -37.945 1.00 64.54  ? 541  PRO   A CB  1 
ATOM   4288 C  CG  . PRO   A 1 540 ? -10.116 -85.530  -37.326 1.00 65.82  ? 541  PRO   A CG  1 
ATOM   4289 C  CD  . PRO   A 1 540 ? -9.329  -85.777  -36.055 1.00 66.04  ? 541  PRO   A CD  1 
ATOM   4290 N  N   . VAL   A 1 541 ? -9.645  -81.132  -36.358 1.00 66.15  ? 542  VAL   A N   1 
ATOM   4291 C  CA  . VAL   A 1 541 ? -10.486 -79.948  -36.011 1.00 69.63  ? 542  VAL   A CA  1 
ATOM   4292 C  C   . VAL   A 1 541 ? -10.754 -79.159  -37.299 1.00 74.34  ? 542  VAL   A C   1 
ATOM   4293 O  O   . VAL   A 1 541 ? -9.772  -78.793  -37.982 1.00 71.31  ? 542  VAL   A O   1 
ATOM   4294 C  CB  . VAL   A 1 541 ? -9.794  -79.073  -34.950 1.00 69.59  ? 542  VAL   A CB  1 
ATOM   4295 C  CG1 . VAL   A 1 541 ? -10.625 -77.855  -34.583 1.00 69.03  ? 542  VAL   A CG1 1 
ATOM   4296 C  CG2 . VAL   A 1 541 ? -9.444  -79.873  -33.707 1.00 71.14  ? 542  VAL   A CG2 1 
ATOM   4297 N  N   . GLU   A 1 542 ? -12.031 -78.902  -37.604 1.00 77.45  ? 543  GLU   A N   1 
ATOM   4298 C  CA  . GLU   A 1 542 ? -12.486 -78.260  -38.866 1.00 79.53  ? 543  GLU   A CA  1 
ATOM   4299 C  C   . GLU   A 1 542 ? -13.092 -76.879  -38.566 1.00 78.51  ? 543  GLU   A C   1 
ATOM   4300 O  O   . GLU   A 1 542 ? -13.887 -76.393  -39.393 1.00 82.53  ? 543  GLU   A O   1 
ATOM   4301 C  CB  . GLU   A 1 542 ? -13.484 -79.175  -39.585 1.00 84.14  ? 543  GLU   A CB  1 
ATOM   4302 C  CG  . GLU   A 1 542 ? -12.969 -80.589  -39.841 1.00 90.95  ? 543  GLU   A CG  1 
ATOM   4303 C  CD  . GLU   A 1 542 ? -11.753 -80.736  -40.751 1.00 94.67  ? 543  GLU   A CD  1 
ATOM   4304 O  OE1 . GLU   A 1 542 ? -11.113 -81.811  -40.703 1.00 89.56  ? 543  GLU   A OE1 1 
ATOM   4305 O  OE2 . GLU   A 1 542 ? -11.449 -79.789  -41.515 1.00 94.52  ? 543  GLU   A OE2 1 
ATOM   4306 N  N   . VAL   A 1 543 ? -12.723 -76.258  -37.441 1.00 73.94  ? 544  VAL   A N   1 
ATOM   4307 C  CA  . VAL   A 1 543 ? -13.134 -74.867  -37.081 1.00 74.32  ? 544  VAL   A CA  1 
ATOM   4308 C  C   . VAL   A 1 543 ? -11.937 -74.146  -36.463 1.00 73.13  ? 544  VAL   A C   1 
ATOM   4309 O  O   . VAL   A 1 543 ? -10.983 -74.831  -36.052 1.00 76.53  ? 544  VAL   A O   1 
ATOM   4310 C  CB  . VAL   A 1 543 ? -14.332 -74.847  -36.112 1.00 76.82  ? 544  VAL   A CB  1 
ATOM   4311 C  CG1 . VAL   A 1 543 ? -15.605 -75.345  -36.776 1.00 79.62  ? 544  VAL   A CG1 1 
ATOM   4312 C  CG2 . VAL   A 1 543 ? -14.050 -75.626  -34.837 1.00 78.14  ? 544  VAL   A CG2 1 
ATOM   4313 N  N   . ASN   A 1 544 ? -11.994 -72.813  -36.419 1.00 72.28  ? 545  ASN   A N   1 
ATOM   4314 C  CA  . ASN   A 1 544 ? -11.158 -71.979  -35.517 1.00 67.92  ? 545  ASN   A CA  1 
ATOM   4315 C  C   . ASN   A 1 544 ? -11.839 -72.036  -34.150 1.00 64.75  ? 545  ASN   A C   1 
ATOM   4316 O  O   . ASN   A 1 544 ? -13.083 -72.114  -34.130 1.00 65.55  ? 545  ASN   A O   1 
ATOM   4317 C  CB  . ASN   A 1 544 ? -10.983 -70.550  -36.036 1.00 69.33  ? 545  ASN   A CB  1 
ATOM   4318 C  CG  . ASN   A 1 544 ? -10.436 -70.492  -37.447 1.00 71.58  ? 545  ASN   A CG  1 
ATOM   4319 O  OD1 . ASN   A 1 544 ? -9.377  -71.041  -37.732 1.00 79.21  ? 545  ASN   A OD1 1 
ATOM   4320 N  ND2 . ASN   A 1 544 ? -11.147 -69.825  -38.341 1.00 73.90  ? 545  ASN   A ND2 1 
ATOM   4321 N  N   . THR   A 1 545 ? -11.061 -72.057  -33.065 1.00 64.23  ? 546  THR   A N   1 
ATOM   4322 C  CA  . THR   A 1 545 ? -11.557 -72.296  -31.682 1.00 60.16  ? 546  THR   A CA  1 
ATOM   4323 C  C   . THR   A 1 545 ? -10.397 -72.165  -30.687 1.00 58.00  ? 546  THR   A C   1 
ATOM   4324 O  O   . THR   A 1 545 ? -9.281  -71.838  -31.123 1.00 56.23  ? 546  THR   A O   1 
ATOM   4325 C  CB  . THR   A 1 545 ? -12.239 -73.668  -31.590 1.00 59.60  ? 546  THR   A CB  1 
ATOM   4326 O  OG1 . THR   A 1 545 ? -12.822 -73.794  -30.292 1.00 60.85  ? 546  THR   A OG1 1 
ATOM   4327 C  CG2 . THR   A 1 545 ? -11.288 -74.817  -31.848 1.00 59.71  ? 546  THR   A CG2 1 
ATOM   4328 N  N   . VAL   A 1 546 ? -10.673 -72.409  -29.402 1.00 58.51  ? 547  VAL   A N   1 
ATOM   4329 C  CA  . VAL   A 1 546 ? -9.686  -72.392  -28.280 1.00 57.18  ? 547  VAL   A CA  1 
ATOM   4330 C  C   . VAL   A 1 546 ? -9.913  -73.638  -27.417 1.00 57.60  ? 547  VAL   A C   1 
ATOM   4331 O  O   . VAL   A 1 546 ? -11.051 -73.832  -26.965 1.00 62.68  ? 547  VAL   A O   1 
ATOM   4332 C  CB  . VAL   A 1 546 ? -9.822  -71.103  -27.451 1.00 57.15  ? 547  VAL   A CB  1 
ATOM   4333 C  CG1 . VAL   A 1 546 ? -8.876  -71.085  -26.259 1.00 57.48  ? 547  VAL   A CG1 1 
ATOM   4334 C  CG2 . VAL   A 1 546 ? -9.625  -69.870  -28.320 1.00 58.29  ? 547  VAL   A CG2 1 
ATOM   4335 N  N   . LEU   A 1 547 ? -8.865  -74.438  -27.199 1.00 56.58  ? 548  LEU   A N   1 
ATOM   4336 C  CA  . LEU   A 1 547 ? -8.920  -75.730  -26.462 1.00 54.99  ? 548  LEU   A CA  1 
ATOM   4337 C  C   . LEU   A 1 547 ? -8.725  -75.457  -24.970 1.00 56.01  ? 548  LEU   A C   1 
ATOM   4338 O  O   . LEU   A 1 547 ? -7.665  -74.922  -24.612 1.00 59.68  ? 548  LEU   A O   1 
ATOM   4339 C  CB  . LEU   A 1 547 ? -7.823  -76.651  -27.005 1.00 54.74  ? 548  LEU   A CB  1 
ATOM   4340 C  CG  . LEU   A 1 547 ? -7.637  -77.985  -26.282 1.00 54.01  ? 548  LEU   A CG  1 
ATOM   4341 C  CD1 . LEU   A 1 547 ? -8.771  -78.951  -26.613 1.00 53.09  ? 548  LEU   A CD1 1 
ATOM   4342 C  CD2 . LEU   A 1 547 ? -6.288  -78.594  -26.642 1.00 54.20  ? 548  LEU   A CD2 1 
ATOM   4343 N  N   . HIS   A 1 548 ? -9.708  -75.812  -24.139 1.00 55.60  ? 549  HIS   A N   1 
ATOM   4344 C  CA  . HIS   A 1 548 ? -9.696  -75.577  -22.670 1.00 54.92  ? 549  HIS   A CA  1 
ATOM   4345 C  C   . HIS   A 1 548 ? -9.544  -76.898  -21.905 1.00 53.66  ? 549  HIS   A C   1 
ATOM   4346 O  O   . HIS   A 1 548 ? -9.176  -76.845  -20.712 1.00 54.87  ? 549  HIS   A O   1 
ATOM   4347 C  CB  . HIS   A 1 548 ? -10.944 -74.781  -22.269 1.00 57.42  ? 549  HIS   A CB  1 
ATOM   4348 C  CG  . HIS   A 1 548 ? -10.980 -73.418  -22.879 1.00 59.76  ? 549  HIS   A CG  1 
ATOM   4349 N  ND1 . HIS   A 1 548 ? -11.776 -73.114  -23.969 1.00 59.24  ? 549  HIS   A ND1 1 
ATOM   4350 C  CD2 . HIS   A 1 548 ? -10.295 -72.292  -22.581 1.00 56.24  ? 549  HIS   A CD2 1 
ATOM   4351 C  CE1 . HIS   A 1 548 ? -11.595 -71.854  -24.302 1.00 59.83  ? 549  HIS   A CE1 1 
ATOM   4352 N  NE2 . HIS   A 1 548 ? -10.690 -71.329  -23.463 1.00 58.22  ? 549  HIS   A NE2 1 
ATOM   4353 N  N   . GLY   A 1 549 ? -9.792  -78.036  -22.559 1.00 51.55  ? 550  GLY   A N   1 
ATOM   4354 C  CA  . GLY   A 1 549 ? -9.626  -79.363  -21.941 1.00 50.88  ? 550  GLY   A CA  1 
ATOM   4355 C  C   . GLY   A 1 549 ? -10.180 -80.483  -22.803 1.00 50.38  ? 550  GLY   A C   1 
ATOM   4356 O  O   . GLY   A 1 549 ? -10.417 -80.257  -24.006 1.00 51.50  ? 550  GLY   A O   1 
ATOM   4357 N  N   . PHE   A 1 550 ? -10.367 -81.655  -22.196 1.00 48.00  ? 551  PHE   A N   1 
ATOM   4358 C  CA  . PHE   A 1 550 ? -10.821 -82.903  -22.855 1.00 48.26  ? 551  PHE   A CA  1 
ATOM   4359 C  C   . PHE   A 1 550 ? -11.960 -83.514  -22.041 1.00 48.86  ? 551  PHE   A C   1 
ATOM   4360 O  O   . PHE   A 1 550 ? -11.802 -83.683  -20.817 1.00 52.16  ? 551  PHE   A O   1 
ATOM   4361 C  CB  . PHE   A 1 550 ? -9.648  -83.870  -23.015 1.00 46.56  ? 551  PHE   A CB  1 
ATOM   4362 C  CG  . PHE   A 1 550 ? -8.623  -83.395  -24.008 1.00 49.01  ? 551  PHE   A CG  1 
ATOM   4363 C  CD1 . PHE   A 1 550 ? -7.646  -82.481  -23.639 1.00 50.63  ? 551  PHE   A CD1 1 
ATOM   4364 C  CD2 . PHE   A 1 550 ? -8.655  -83.838  -25.321 1.00 49.46  ? 551  PHE   A CD2 1 
ATOM   4365 C  CE1 . PHE   A 1 550 ? -6.710  -82.035  -24.559 1.00 50.35  ? 551  PHE   A CE1 1 
ATOM   4366 C  CE2 . PHE   A 1 550 ? -7.720  -83.390  -26.241 1.00 51.08  ? 551  PHE   A CE2 1 
ATOM   4367 C  CZ  . PHE   A 1 550 ? -6.753  -82.486  -25.859 1.00 51.10  ? 551  PHE   A CZ  1 
ATOM   4368 N  N   . ALA   A 1 551 ? -13.078 -83.803  -22.709 1.00 48.52  ? 552  ALA   A N   1 
ATOM   4369 C  CA  . ALA   A 1 551 ? -14.244 -84.510  -22.139 1.00 49.18  ? 552  ALA   A CA  1 
ATOM   4370 C  C   . ALA   A 1 551 ? -13.977 -86.015  -22.211 1.00 50.12  ? 552  ALA   A C   1 
ATOM   4371 O  O   . ALA   A 1 551 ? -13.612 -86.508  -23.296 1.00 52.50  ? 552  ALA   A O   1 
ATOM   4372 C  CB  . ALA   A 1 551 ? -15.500 -84.131  -22.879 1.00 50.36  ? 552  ALA   A CB  1 
ATOM   4373 N  N   . GLY   A 1 552 ? -14.134 -86.706  -21.086 1.00 48.51  ? 553  GLY   A N   1 
ATOM   4374 C  CA  . GLY   A 1 552 ? -13.994 -88.169  -21.001 1.00 50.23  ? 553  GLY   A CA  1 
ATOM   4375 C  C   . GLY   A 1 552 ? -15.352 -88.831  -20.899 1.00 50.48  ? 553  GLY   A C   1 
ATOM   4376 O  O   . GLY   A 1 552 ? -16.252 -88.247  -20.252 1.00 50.91  ? 553  GLY   A O   1 
ATOM   4377 N  N   . TYR   A 1 553 ? -15.498 -89.986  -21.546 1.00 50.54  ? 554  TYR   A N   1 
ATOM   4378 C  CA  . TYR   A 1 553 ? -16.702 -90.852  -21.512 1.00 51.35  ? 554  TYR   A CA  1 
ATOM   4379 C  C   . TYR   A 1 553 ? -16.222 -92.306  -21.467 1.00 52.87  ? 554  TYR   A C   1 
ATOM   4380 O  O   . TYR   A 1 553 ? -14.996 -92.545  -21.406 1.00 49.82  ? 554  TYR   A O   1 
ATOM   4381 C  CB  . TYR   A 1 553 ? -17.595 -90.621  -22.737 1.00 51.75  ? 554  TYR   A CB  1 
ATOM   4382 C  CG  . TYR   A 1 553 ? -17.886 -89.186  -23.107 1.00 51.61  ? 554  TYR   A CG  1 
ATOM   4383 C  CD1 . TYR   A 1 553 ? -18.970 -88.512  -22.569 1.00 52.17  ? 554  TYR   A CD1 1 
ATOM   4384 C  CD2 . TYR   A 1 553 ? -17.107 -88.513  -24.037 1.00 52.05  ? 554  TYR   A CD2 1 
ATOM   4385 C  CE1 . TYR   A 1 553 ? -19.257 -87.202  -22.922 1.00 53.48  ? 554  TYR   A CE1 1 
ATOM   4386 C  CE2 . TYR   A 1 553 ? -17.376 -87.200  -24.396 1.00 53.41  ? 554  TYR   A CE2 1 
ATOM   4387 C  CZ  . TYR   A 1 553 ? -18.455 -86.540  -23.836 1.00 54.11  ? 554  TYR   A CZ  1 
ATOM   4388 O  OH  . TYR   A 1 553 ? -18.737 -85.253  -24.191 1.00 54.98  ? 554  TYR   A OH  1 
ATOM   4389 N  N   . PHE   A 1 554 ? -17.146 -93.264  -21.527 1.00 54.63  ? 555  PHE   A N   1 
ATOM   4390 C  CA  . PHE   A 1 554 ? -16.783 -94.699  -21.607 1.00 55.29  ? 555  PHE   A CA  1 
ATOM   4391 C  C   . PHE   A 1 554 ? -17.939 -95.534  -22.159 1.00 52.88  ? 555  PHE   A C   1 
ATOM   4392 O  O   . PHE   A 1 554 ? -19.101 -95.069  -22.185 1.00 48.91  ? 555  PHE   A O   1 
ATOM   4393 C  CB  . PHE   A 1 554 ? -16.376 -95.221  -20.227 1.00 55.76  ? 555  PHE   A CB  1 
ATOM   4394 C  CG  . PHE   A 1 554 ? -17.554 -95.548  -19.352 1.00 53.18  ? 555  PHE   A CG  1 
ATOM   4395 C  CD1 . PHE   A 1 554 ? -18.308 -94.540  -18.778 1.00 52.47  ? 555  PHE   A CD1 1 
ATOM   4396 C  CD2 . PHE   A 1 554 ? -17.947 -96.862  -19.162 1.00 53.26  ? 555  PHE   A CD2 1 
ATOM   4397 C  CE1 . PHE   A 1 554 ? -19.412 -94.844  -17.999 1.00 54.49  ? 555  PHE   A CE1 1 
ATOM   4398 C  CE2 . PHE   A 1 554 ? -19.056 -97.164  -18.392 1.00 52.24  ? 555  PHE   A CE2 1 
ATOM   4399 C  CZ  . PHE   A 1 554 ? -19.787 -96.155  -17.812 1.00 54.03  ? 555  PHE   A CZ  1 
ATOM   4400 N  N   . GLU   A 1 555 ? -17.582 -96.752  -22.569 1.00 53.13  ? 556  GLU   A N   1 
ATOM   4401 C  CA  . GLU   A 1 555 ? -18.491 -97.867  -22.938 1.00 57.90  ? 556  GLU   A CA  1 
ATOM   4402 C  C   . GLU   A 1 555 ? -17.986 -99.129  -22.237 1.00 59.26  ? 556  GLU   A C   1 
ATOM   4403 O  O   . GLU   A 1 555 ? -16.752 -99.295  -22.113 1.00 60.15  ? 556  GLU   A O   1 
ATOM   4404 C  CB  . GLU   A 1 555 ? -18.499 -98.111  -24.449 1.00 57.62  ? 556  GLU   A CB  1 
ATOM   4405 C  CG  . GLU   A 1 555 ? -19.126 -96.992  -25.255 1.00 58.56  ? 556  GLU   A CG  1 
ATOM   4406 C  CD  . GLU   A 1 555 ? -19.030 -97.179  -26.759 1.00 59.54  ? 556  GLU   A CD  1 
ATOM   4407 O  OE1 . GLU   A 1 555 ? -19.856 -96.582  -27.478 1.00 60.68  ? 556  GLU   A OE1 1 
ATOM   4408 O  OE2 . GLU   A 1 555 ? -18.120 -97.907  -27.208 1.00 58.65  ? 556  GLU   A OE2 1 
ATOM   4409 N  N   . THR   A 1 556 ? -18.902 -99.987  -21.796 1.00 58.71  ? 557  THR   A N   1 
ATOM   4410 C  CA  . THR   A 1 556 ? -18.565 -101.297 -21.193 1.00 58.07  ? 557  THR   A CA  1 
ATOM   4411 C  C   . THR   A 1 556 ? -19.438 -102.365 -21.847 1.00 59.76  ? 557  THR   A C   1 
ATOM   4412 O  O   . THR   A 1 556 ? -20.641 -102.112 -22.069 1.00 58.75  ? 557  THR   A O   1 
ATOM   4413 C  CB  . THR   A 1 556 ? -18.699 -101.276 -19.665 1.00 55.88  ? 557  THR   A CB  1 
ATOM   4414 O  OG1 . THR   A 1 556 ? -18.182 -102.516 -19.176 1.00 53.39  ? 557  THR   A OG1 1 
ATOM   4415 C  CG2 . THR   A 1 556 ? -20.120 -101.065 -19.189 1.00 55.19  ? 557  THR   A CG2 1 
ATOM   4416 N  N   . VAL   A 1 557 ? -18.816 -103.491 -22.178 1.00 60.61  ? 558  VAL   A N   1 
ATOM   4417 C  CA  . VAL   A 1 557 ? -19.506 -104.756 -22.535 1.00 63.09  ? 558  VAL   A CA  1 
ATOM   4418 C  C   . VAL   A 1 557 ? -19.665 -105.543 -21.232 1.00 62.87  ? 558  VAL   A C   1 
ATOM   4419 O  O   . VAL   A 1 557 ? -18.639 -106.023 -20.709 1.00 57.20  ? 558  VAL   A O   1 
ATOM   4420 C  CB  . VAL   A 1 557 ? -18.709 -105.521 -23.607 1.00 65.81  ? 558  VAL   A CB  1 
ATOM   4421 C  CG1 . VAL   A 1 557 ? -19.254 -106.924 -23.838 1.00 67.74  ? 558  VAL   A CG1 1 
ATOM   4422 C  CG2 . VAL   A 1 557 ? -18.660 -104.735 -24.910 1.00 66.57  ? 558  VAL   A CG2 1 
ATOM   4423 N  N   . LEU   A 1 558 ? -20.890 -105.608 -20.701 1.00 65.27  ? 559  LEU   A N   1 
ATOM   4424 C  CA  . LEU   A 1 558 ? -21.236 -106.487 -19.555 1.00 66.83  ? 559  LEU   A CA  1 
ATOM   4425 C  C   . LEU   A 1 558 ? -21.067 -107.933 -20.021 1.00 68.34  ? 559  LEU   A C   1 
ATOM   4426 O  O   . LEU   A 1 558 ? -20.302 -108.696 -19.384 1.00 67.82  ? 559  LEU   A O   1 
ATOM   4427 C  CB  . LEU   A 1 558 ? -22.674 -106.225 -19.097 1.00 65.82  ? 559  LEU   A CB  1 
ATOM   4428 C  CG  . LEU   A 1 558 ? -22.990 -104.797 -18.661 1.00 67.02  ? 559  LEU   A CG  1 
ATOM   4429 C  CD1 . LEU   A 1 558 ? -24.432 -104.690 -18.189 1.00 67.49  ? 559  LEU   A CD1 1 
ATOM   4430 C  CD2 . LEU   A 1 558 ? -22.040 -104.330 -17.567 1.00 67.89  ? 559  LEU   A CD2 1 
ATOM   4431 N  N   . TYR   A 1 559 ? -21.734 -108.276 -21.125 1.00 71.30  ? 560  TYR   A N   1 
ATOM   4432 C  CA  . TYR   A 1 559 ? -21.683 -109.639 -21.712 1.00 73.88  ? 560  TYR   A CA  1 
ATOM   4433 C  C   . TYR   A 1 559 ? -22.228 -109.602 -23.131 1.00 70.90  ? 560  TYR   A C   1 
ATOM   4434 O  O   . TYR   A 1 559 ? -23.307 -109.028 -23.330 1.00 68.57  ? 560  TYR   A O   1 
ATOM   4435 C  CB  . TYR   A 1 559 ? -22.525 -110.604 -20.876 1.00 74.20  ? 560  TYR   A CB  1 
ATOM   4436 C  CG  . TYR   A 1 559 ? -22.429 -112.046 -21.295 1.00 72.53  ? 560  TYR   A CG  1 
ATOM   4437 C  CD1 . TYR   A 1 559 ? -21.255 -112.755 -21.116 1.00 73.81  ? 560  TYR   A CD1 1 
ATOM   4438 C  CD2 . TYR   A 1 559 ? -23.510 -112.703 -21.858 1.00 73.18  ? 560  TYR   A CD2 1 
ATOM   4439 C  CE1 . TYR   A 1 559 ? -21.153 -114.083 -21.491 1.00 74.23  ? 560  TYR   A CE1 1 
ATOM   4440 C  CE2 . TYR   A 1 559 ? -23.427 -114.033 -22.234 1.00 70.71  ? 560  TYR   A CE2 1 
ATOM   4441 C  CZ  . TYR   A 1 559 ? -22.243 -114.721 -22.050 1.00 72.99  ? 560  TYR   A CZ  1 
ATOM   4442 O  OH  . TYR   A 1 559 ? -22.139 -116.028 -22.416 1.00 78.22  ? 560  TYR   A OH  1 
ATOM   4443 N  N   . GLN   A 1 560 ? -21.505 -110.204 -24.071 1.00 72.81  ? 561  GLN   A N   1 
ATOM   4444 C  CA  . GLN   A 1 560 ? -21.975 -110.288 -25.481 1.00 74.62  ? 561  GLN   A CA  1 
ATOM   4445 C  C   . GLN   A 1 560 ? -22.391 -108.907 -25.991 1.00 72.01  ? 561  GLN   A C   1 
ATOM   4446 O  O   . GLN   A 1 560 ? -21.549 -107.999 -26.062 1.00 70.77  ? 561  GLN   A O   1 
ATOM   4447 C  CB  . GLN   A 1 560 ? -23.121 -111.291 -25.612 1.00 75.11  ? 561  GLN   A CB  1 
ATOM   4448 C  CG  . GLN   A 1 560 ? -22.626 -112.720 -25.497 1.00 76.12  ? 561  GLN   A CG  1 
ATOM   4449 C  CD  . GLN   A 1 560 ? -23.709 -113.737 -25.749 1.00 77.03  ? 561  GLN   A CD  1 
ATOM   4450 O  OE1 . GLN   A 1 560 ? -24.838 -113.396 -26.096 1.00 75.11  ? 561  GLN   A OE1 1 
ATOM   4451 N  NE2 . GLN   A 1 560 ? -23.365 -115.003 -25.579 1.00 75.74  ? 561  GLN   A NE2 1 
ATOM   4452 N  N   . ASP   A 1 561 ? -23.652 -108.784 -26.378 1.00 71.21  ? 562  ASP   A N   1 
ATOM   4453 C  CA  . ASP   A 1 561 ? -24.184 -107.512 -26.927 1.00 69.26  ? 562  ASP   A CA  1 
ATOM   4454 C  C   . ASP   A 1 561 ? -24.761 -106.619 -25.828 1.00 69.04  ? 562  ASP   A C   1 
ATOM   4455 O  O   . ASP   A 1 561 ? -25.209 -105.510 -26.167 1.00 68.25  ? 562  ASP   A O   1 
ATOM   4456 C  CB  . ASP   A 1 561 ? -25.246 -107.793 -27.979 1.00 71.09  ? 562  ASP   A CB  1 
ATOM   4457 C  CG  . ASP   A 1 561 ? -26.290 -108.798 -27.525 1.00 72.12  ? 562  ASP   A CG  1 
ATOM   4458 O  OD1 . ASP   A 1 561 ? -25.929 -109.729 -26.777 1.00 71.60  ? 562  ASP   A OD1 1 
ATOM   4459 O  OD2 . ASP   A 1 561 ? -27.452 -108.643 -27.922 1.00 74.97  ? 562  ASP   A OD2 1 
ATOM   4460 N  N   . ILE   A 1 562 ? -24.759 -107.059 -24.571 1.00 68.76  ? 563  ILE   A N   1 
ATOM   4461 C  CA  . ILE   A 1 562 ? -25.325 -106.240 -23.462 1.00 71.55  ? 563  ILE   A CA  1 
ATOM   4462 C  C   . ILE   A 1 562 ? -24.257 -105.222 -23.055 1.00 69.78  ? 563  ILE   A C   1 
ATOM   4463 O  O   . ILE   A 1 562 ? -23.180 -105.639 -22.575 1.00 68.24  ? 563  ILE   A O   1 
ATOM   4464 C  CB  . ILE   A 1 562 ? -25.811 -107.104 -22.283 1.00 74.27  ? 563  ILE   A CB  1 
ATOM   4465 C  CG1 . ILE   A 1 562 ? -26.537 -108.366 -22.760 1.00 75.33  ? 563  ILE   A CG1 1 
ATOM   4466 C  CG2 . ILE   A 1 562 ? -26.686 -106.275 -21.354 1.00 73.84  ? 563  ILE   A CG2 1 
ATOM   4467 C  CD1 . ILE   A 1 562 ? -27.626 -108.107 -23.780 1.00 74.40  ? 563  ILE   A CD1 1 
ATOM   4468 N  N   . THR   A 1 563 ? -24.549 -103.940 -23.281 1.00 66.49  ? 564  THR   A N   1 
ATOM   4469 C  CA  . THR   A 1 563 ? -23.598 -102.816 -23.111 1.00 69.05  ? 564  THR   A CA  1 
ATOM   4470 C  C   . THR   A 1 563 ? -24.236 -101.728 -22.248 1.00 67.46  ? 564  THR   A C   1 
ATOM   4471 O  O   . THR   A 1 563 ? -25.480 -101.662 -22.192 1.00 68.46  ? 564  THR   A O   1 
ATOM   4472 C  CB  . THR   A 1 563 ? -23.177 -102.239 -24.467 1.00 70.53  ? 564  THR   A CB  1 
ATOM   4473 O  OG1 . THR   A 1 563 ? -24.337 -101.670 -25.080 1.00 71.57  ? 564  THR   A OG1 1 
ATOM   4474 C  CG2 . THR   A 1 563 ? -22.558 -103.273 -25.381 1.00 70.32  ? 564  THR   A CG2 1 
ATOM   4475 N  N   . LEU   A 1 564 ? -23.391 -100.930 -21.596 1.00 65.36  ? 565  LEU   A N   1 
ATOM   4476 C  CA  . LEU   A 1 564 ? -23.733 -99.599  -21.039 1.00 63.03  ? 565  LEU   A CA  1 
ATOM   4477 C  C   . LEU   A 1 564 ? -22.743 -98.590  -21.625 1.00 63.41  ? 565  LEU   A C   1 
ATOM   4478 O  O   . LEU   A 1 564 ? -21.582 -98.987  -21.902 1.00 62.74  ? 565  LEU   A O   1 
ATOM   4479 C  CB  . LEU   A 1 564 ? -23.656 -99.647  -19.511 1.00 63.96  ? 565  LEU   A CB  1 
ATOM   4480 C  CG  . LEU   A 1 564 ? -24.675 -100.559 -18.830 1.00 63.43  ? 565  LEU   A CG  1 
ATOM   4481 C  CD1 . LEU   A 1 564 ? -24.281 -100.823 -17.386 1.00 63.53  ? 565  LEU   A CD1 1 
ATOM   4482 C  CD2 . LEU   A 1 564 ? -26.077 -99.968  -18.907 1.00 62.73  ? 565  LEU   A CD2 1 
ATOM   4483 N  N   . SER   A 1 565 ? -23.187 -97.348  -21.831 1.00 59.78  ? 566  SER   A N   1 
ATOM   4484 C  CA  . SER   A 1 565 ? -22.400 -96.283  -22.503 1.00 59.31  ? 566  SER   A CA  1 
ATOM   4485 C  C   . SER   A 1 565 ? -22.851 -94.910  -22.009 1.00 57.60  ? 566  SER   A C   1 
ATOM   4486 O  O   . SER   A 1 565 ? -24.060 -94.736  -21.788 1.00 55.49  ? 566  SER   A O   1 
ATOM   4487 C  CB  . SER   A 1 565 ? -22.526 -96.387  -24.000 1.00 58.99  ? 566  SER   A CB  1 
ATOM   4488 O  OG  . SER   A 1 565 ? -21.994 -95.236  -24.639 1.00 58.76  ? 566  SER   A OG  1 
ATOM   4489 N  N   . ILE   A 1 566 ? -21.901 -93.990  -21.830 1.00 58.23  ? 567  ILE   A N   1 
ATOM   4490 C  CA  . ILE   A 1 566 ? -22.184 -92.533  -21.681 1.00 60.40  ? 567  ILE   A CA  1 
ATOM   4491 C  C   . ILE   A 1 566 ? -21.458 -91.750  -22.784 1.00 60.26  ? 567  ILE   A C   1 
ATOM   4492 O  O   . ILE   A 1 566 ? -21.533 -90.504  -22.750 1.00 58.85  ? 567  ILE   A O   1 
ATOM   4493 C  CB  . ILE   A 1 566 ? -21.829 -92.048  -20.264 1.00 61.31  ? 567  ILE   A CB  1 
ATOM   4494 C  CG1 . ILE   A 1 566 ? -20.319 -92.009  -20.024 1.00 61.26  ? 567  ILE   A CG1 1 
ATOM   4495 C  CG2 . ILE   A 1 566 ? -22.546 -92.904  -19.231 1.00 61.76  ? 567  ILE   A CG2 1 
ATOM   4496 C  CD1 . ILE   A 1 566 ? -19.927 -91.303  -18.748 1.00 62.34  ? 567  ILE   A CD1 1 
ATOM   4497 N  N   . ARG   A 1 567 ? -20.800 -92.447  -23.722 1.00 61.49  ? 568  ARG   A N   1 
ATOM   4498 C  CA  . ARG   A 1 567 ? -20.360 -91.883  -25.026 1.00 63.88  ? 568  ARG   A CA  1 
ATOM   4499 C  C   . ARG   A 1 567 ? -21.598 -91.357  -25.746 1.00 64.21  ? 568  ARG   A C   1 
ATOM   4500 O  O   . ARG   A 1 567 ? -22.484 -92.142  -26.075 1.00 62.95  ? 568  ARG   A O   1 
ATOM   4501 C  CB  . ARG   A 1 567 ? -19.647 -92.939  -25.875 1.00 67.41  ? 568  ARG   A CB  1 
ATOM   4502 C  CG  . ARG   A 1 567 ? -19.320 -92.472  -27.287 1.00 73.07  ? 568  ARG   A CG  1 
ATOM   4503 C  CD  . ARG   A 1 567 ? -18.046 -93.078  -27.848 1.00 77.50  ? 568  ARG   A CD  1 
ATOM   4504 N  NE  . ARG   A 1 567 ? -18.277 -94.249  -28.687 1.00 78.63  ? 568  ARG   A NE  1 
ATOM   4505 C  CZ  . ARG   A 1 567 ? -18.192 -94.282  -30.016 1.00 78.20  ? 568  ARG   A CZ  1 
ATOM   4506 N  NH1 . ARG   A 1 567 ? -17.883 -93.197  -30.709 1.00 80.57  ? 568  ARG   A NH1 1 
ATOM   4507 N  NH2 . ARG   A 1 567 ? -18.418 -95.416  -30.655 1.00 78.24  ? 568  ARG   A NH2 1 
ATOM   4508 N  N   . PRO   A 1 568 ? -21.707 -90.029  -25.993 1.00 65.75  ? 569  PRO   A N   1 
ATOM   4509 C  CA  . PRO   A 1 568 ? -22.958 -89.424  -26.461 1.00 65.64  ? 569  PRO   A CA  1 
ATOM   4510 C  C   . PRO   A 1 568 ? -23.603 -90.120  -27.667 1.00 66.00  ? 569  PRO   A C   1 
ATOM   4511 O  O   . PRO   A 1 568 ? -24.810 -90.239  -27.679 1.00 68.87  ? 569  PRO   A O   1 
ATOM   4512 C  CB  . PRO   A 1 568 ? -22.551 -88.000  -26.864 1.00 63.07  ? 569  PRO   A CB  1 
ATOM   4513 C  CG  . PRO   A 1 568 ? -21.347 -87.702  -25.997 1.00 64.61  ? 569  PRO   A CG  1 
ATOM   4514 C  CD  . PRO   A 1 568 ? -20.637 -89.031  -25.836 1.00 64.23  ? 569  PRO   A CD  1 
ATOM   4515 N  N   . GLU   A 1 569 ? -22.794 -90.571  -28.629 1.00 67.21  ? 570  GLU   A N   1 
ATOM   4516 C  CA  . GLU   A 1 569 ? -23.282 -91.123  -29.924 1.00 72.37  ? 570  GLU   A CA  1 
ATOM   4517 C  C   . GLU   A 1 569 ? -23.779 -92.572  -29.750 1.00 71.27  ? 570  GLU   A C   1 
ATOM   4518 O  O   . GLU   A 1 569 ? -24.396 -93.091  -30.706 1.00 74.47  ? 570  GLU   A O   1 
ATOM   4519 C  CB  . GLU   A 1 569 ? -22.218 -90.993  -31.021 1.00 75.66  ? 570  GLU   A CB  1 
ATOM   4520 C  CG  . GLU   A 1 569 ? -20.832 -91.489  -30.639 1.00 82.40  ? 570  GLU   A CG  1 
ATOM   4521 C  CD  . GLU   A 1 569 ? -19.804 -90.413  -30.315 1.00 82.98  ? 570  GLU   A CD  1 
ATOM   4522 O  OE1 . GLU   A 1 569 ? -18.644 -90.566  -30.751 1.00 82.63  ? 570  GLU   A OE1 1 
ATOM   4523 O  OE2 . GLU   A 1 569 ? -20.157 -89.434  -29.620 1.00 82.25  ? 570  GLU   A OE2 1 
ATOM   4524 N  N   . THR   A 1 570 ? -23.550 -93.199  -28.588 1.00 68.76  ? 571  THR   A N   1 
ATOM   4525 C  CA  . THR   A 1 570 ? -24.055 -94.560  -28.249 1.00 64.86  ? 571  THR   A CA  1 
ATOM   4526 C  C   . THR   A 1 570 ? -24.626 -94.589  -26.825 1.00 65.94  ? 571  THR   A C   1 
ATOM   4527 O  O   . THR   A 1 570 ? -24.761 -95.705  -26.274 1.00 65.02  ? 571  THR   A O   1 
ATOM   4528 C  CB  . THR   A 1 570 ? -22.956 -95.624  -28.382 1.00 62.56  ? 571  THR   A CB  1 
ATOM   4529 O  OG1 . THR   A 1 570 ? -22.139 -95.571  -27.213 1.00 61.37  ? 571  THR   A OG1 1 
ATOM   4530 C  CG2 . THR   A 1 570 ? -22.094 -95.448  -29.613 1.00 63.25  ? 571  THR   A CG2 1 
ATOM   4531 N  N   . HIS   A 1 571 ? -24.971 -93.429  -26.258 1.00 66.19  ? 572  HIS   A N   1 
ATOM   4532 C  CA  . HIS   A 1 571 ? -25.437 -93.291  -24.851 1.00 70.24  ? 572  HIS   A CA  1 
ATOM   4533 C  C   . HIS   A 1 571 ? -26.553 -94.306  -24.582 1.00 72.31  ? 572  HIS   A C   1 
ATOM   4534 O  O   . HIS   A 1 571 ? -27.538 -94.303  -25.345 1.00 71.67  ? 572  HIS   A O   1 
ATOM   4535 C  CB  . HIS   A 1 571 ? -25.906 -91.860  -24.556 1.00 71.17  ? 572  HIS   A CB  1 
ATOM   4536 C  CG  . HIS   A 1 571 ? -25.764 -91.463  -23.124 1.00 71.64  ? 572  HIS   A CG  1 
ATOM   4537 N  ND1 . HIS   A 1 571 ? -26.549 -91.996  -22.124 1.00 71.20  ? 572  HIS   A ND1 1 
ATOM   4538 C  CD2 . HIS   A 1 571 ? -24.939 -90.581  -22.521 1.00 73.97  ? 572  HIS   A CD2 1 
ATOM   4539 C  CE1 . HIS   A 1 571 ? -26.210 -91.463  -20.968 1.00 69.75  ? 572  HIS   A CE1 1 
ATOM   4540 N  NE2 . HIS   A 1 571 ? -25.226 -90.595  -21.184 1.00 73.43  ? 572  HIS   A NE2 1 
ATOM   4541 N  N   . SER   A 1 572 ? -26.384 -95.150  -23.557 1.00 72.90  ? 573  SER   A N   1 
ATOM   4542 C  CA  . SER   A 1 572 ? -27.449 -96.016  -22.985 1.00 73.92  ? 573  SER   A CA  1 
ATOM   4543 C  C   . SER   A 1 572 ? -28.680 -95.157  -22.715 1.00 76.53  ? 573  SER   A C   1 
ATOM   4544 O  O   . SER   A 1 572 ? -28.546 -93.973  -22.423 1.00 73.98  ? 573  SER   A O   1 
ATOM   4545 C  CB  . SER   A 1 572 ? -26.987 -96.707  -21.726 1.00 73.20  ? 573  SER   A CB  1 
ATOM   4546 O  OG  . SER   A 1 572 ? -25.989 -97.676  -22.005 1.00 71.85  ? 573  SER   A OG  1 
ATOM   4547 N  N   . PRO   A 1 573 ? -29.911 -95.706  -22.816 1.00 83.83  ? 574  PRO   A N   1 
ATOM   4548 C  CA  . PRO   A 1 573 ? -31.123 -94.926  -22.559 1.00 84.03  ? 574  PRO   A CA  1 
ATOM   4549 C  C   . PRO   A 1 573 ? -31.345 -94.724  -21.053 1.00 87.35  ? 574  PRO   A C   1 
ATOM   4550 O  O   . PRO   A 1 573 ? -32.030 -95.525  -20.451 1.00 89.05  ? 574  PRO   A O   1 
ATOM   4551 C  CB  . PRO   A 1 573 ? -32.224 -95.785  -23.196 1.00 83.19  ? 574  PRO   A CB  1 
ATOM   4552 C  CG  . PRO   A 1 573 ? -31.712 -97.206  -23.042 1.00 84.73  ? 574  PRO   A CG  1 
ATOM   4553 C  CD  . PRO   A 1 573 ? -30.205 -97.102  -23.179 1.00 85.35  ? 574  PRO   A CD  1 
ATOM   4554 N  N   . GLY   A 1 574 ? -30.769 -93.653  -20.498 1.00 89.23  ? 575  GLY   A N   1 
ATOM   4555 C  CA  . GLY   A 1 574 ? -30.646 -93.421  -19.044 1.00 87.17  ? 575  GLY   A CA  1 
ATOM   4556 C  C   . GLY   A 1 574 ? -29.189 -93.435  -18.618 1.00 82.34  ? 575  GLY   A C   1 
ATOM   4557 O  O   . GLY   A 1 574 ? -28.335 -93.142  -19.467 1.00 81.20  ? 575  GLY   A O   1 
ATOM   4558 N  N   . MET   A 1 575 ? -28.908 -93.787  -17.360 1.00 81.73  ? 576  MET   A N   1 
ATOM   4559 C  CA  . MET   A 1 575 ? -27.583 -93.583  -16.708 1.00 83.90  ? 576  MET   A CA  1 
ATOM   4560 C  C   . MET   A 1 575 ? -27.242 -92.087  -16.755 1.00 87.96  ? 576  MET   A C   1 
ATOM   4561 O  O   . MET   A 1 575 ? -26.056 -91.733  -16.932 1.00 76.42  ? 576  MET   A O   1 
ATOM   4562 C  CB  . MET   A 1 575 ? -26.491 -94.428  -17.376 1.00 82.41  ? 576  MET   A CB  1 
ATOM   4563 C  CG  . MET   A 1 575 ? -26.402 -95.827  -16.803 1.00 83.00  ? 576  MET   A CG  1 
ATOM   4564 S  SD  . MET   A 1 575 ? -25.006 -96.769  -17.449 1.00 88.50  ? 576  MET   A SD  1 
ATOM   4565 C  CE  . MET   A 1 575 ? -23.623 -95.911  -16.701 1.00 88.45  ? 576  MET   A CE  1 
ATOM   4566 N  N   . PHE   A 1 576 ? -28.278 -91.260  -16.574 1.00 98.86  ? 577  PHE   A N   1 
ATOM   4567 C  CA  . PHE   A 1 576 ? -28.262 -89.772  -16.563 1.00 108.49 ? 577  PHE   A CA  1 
ATOM   4568 C  C   . PHE   A 1 576 ? -27.345 -89.249  -15.449 1.00 102.37 ? 577  PHE   A C   1 
ATOM   4569 O  O   . PHE   A 1 576 ? -26.754 -88.159  -15.613 1.00 96.73  ? 577  PHE   A O   1 
ATOM   4570 C  CB  . PHE   A 1 576 ? -29.687 -89.236  -16.377 1.00 125.68 ? 577  PHE   A CB  1 
ATOM   4571 C  CG  . PHE   A 1 576 ? -30.444 -89.758  -15.178 1.00 134.13 ? 577  PHE   A CG  1 
ATOM   4572 C  CD1 . PHE   A 1 576 ? -30.291 -89.174  -13.929 1.00 140.72 ? 577  PHE   A CD1 1 
ATOM   4573 C  CD2 . PHE   A 1 576 ? -31.334 -90.818  -15.302 1.00 136.58 ? 577  PHE   A CD2 1 
ATOM   4574 C  CE1 . PHE   A 1 576 ? -30.990 -89.649  -12.830 1.00 144.33 ? 577  PHE   A CE1 1 
ATOM   4575 C  CE2 . PHE   A 1 576 ? -32.032 -91.292  -14.202 1.00 140.23 ? 577  PHE   A CE2 1 
ATOM   4576 C  CZ  . PHE   A 1 576 ? -31.860 -90.707  -12.968 1.00 143.25 ? 577  PHE   A CZ  1 
ATOM   4577 N  N   . SER   A 1 577 ? -27.259 -90.001  -14.347 1.00 95.49  ? 578  SER   A N   1 
ATOM   4578 C  CA  . SER   A 1 577 ? -26.505 -89.671  -13.110 1.00 88.85  ? 578  SER   A CA  1 
ATOM   4579 C  C   . SER   A 1 577 ? -24.999 -89.600  -13.404 1.00 80.49  ? 578  SER   A C   1 
ATOM   4580 O  O   . SER   A 1 577 ? -24.293 -88.865  -12.683 1.00 74.39  ? 578  SER   A O   1 
ATOM   4581 C  CB  . SER   A 1 577 ? -26.816 -90.682  -12.033 1.00 92.08  ? 578  SER   A CB  1 
ATOM   4582 O  OG  . SER   A 1 577 ? -28.063 -91.318  -12.280 1.00 93.87  ? 578  SER   A OG  1 
ATOM   4583 N  N   . TRP   A 1 578 ? -24.537 -90.342  -14.420 1.00 73.34  ? 579  TRP   A N   1 
ATOM   4584 C  CA  . TRP   A 1 578 ? -23.114 -90.466  -14.840 1.00 68.60  ? 579  TRP   A CA  1 
ATOM   4585 C  C   . TRP   A 1 578 ? -22.740 -89.323  -15.782 1.00 65.83  ? 579  TRP   A C   1 
ATOM   4586 O  O   . TRP   A 1 578 ? -22.886 -89.502  -17.006 1.00 67.90  ? 579  TRP   A O   1 
ATOM   4587 C  CB  . TRP   A 1 578 ? -22.869 -91.796  -15.550 1.00 68.92  ? 579  TRP   A CB  1 
ATOM   4588 C  CG  . TRP   A 1 578 ? -23.034 -93.004  -14.690 1.00 70.52  ? 579  TRP   A CG  1 
ATOM   4589 C  CD1 . TRP   A 1 578 ? -24.154 -93.407  -14.022 1.00 70.30  ? 579  TRP   A CD1 1 
ATOM   4590 C  CD2 . TRP   A 1 578 ? -22.030 -93.998  -14.448 1.00 70.98  ? 579  TRP   A CD2 1 
ATOM   4591 N  NE1 . TRP   A 1 578 ? -23.909 -94.580  -13.364 1.00 72.55  ? 579  TRP   A NE1 1 
ATOM   4592 C  CE2 . TRP   A 1 578 ? -22.616 -94.963  -13.606 1.00 72.14  ? 579  TRP   A CE2 1 
ATOM   4593 C  CE3 . TRP   A 1 578 ? -20.700 -94.160  -14.850 1.00 72.85  ? 579  TRP   A CE3 1 
ATOM   4594 C  CZ2 . TRP   A 1 578 ? -21.910 -96.074  -13.164 1.00 74.73  ? 579  TRP   A CZ2 1 
ATOM   4595 C  CZ3 . TRP   A 1 578 ? -20.002 -95.263  -14.410 1.00 75.20  ? 579  TRP   A CZ3 1 
ATOM   4596 C  CH2 . TRP   A 1 578 ? -20.604 -96.206  -13.578 1.00 77.74  ? 579  TRP   A CH2 1 
ATOM   4597 N  N   . PHE   A 1 579 ? -22.235 -88.216  -15.243 1.00 62.73  ? 580  PHE   A N   1 
ATOM   4598 C  CA  . PHE   A 1 579 ? -21.798 -87.048  -16.046 1.00 60.79  ? 580  PHE   A CA  1 
ATOM   4599 C  C   . PHE   A 1 579 ? -20.429 -87.329  -16.657 1.00 56.03  ? 580  PHE   A C   1 
ATOM   4600 O  O   . PHE   A 1 579 ? -19.686 -88.180  -16.174 1.00 50.93  ? 580  PHE   A O   1 
ATOM   4601 C  CB  . PHE   A 1 579 ? -21.789 -85.770  -15.206 1.00 63.46  ? 580  PHE   A CB  1 
ATOM   4602 C  CG  . PHE   A 1 579 ? -23.127 -85.407  -14.619 1.00 62.58  ? 580  PHE   A CG  1 
ATOM   4603 C  CD1 . PHE   A 1 579 ? -24.293 -85.607  -15.341 1.00 61.94  ? 580  PHE   A CD1 1 
ATOM   4604 C  CD2 . PHE   A 1 579 ? -23.219 -84.859  -13.349 1.00 62.35  ? 580  PHE   A CD2 1 
ATOM   4605 C  CE1 . PHE   A 1 579 ? -25.525 -85.276  -14.800 1.00 63.99  ? 580  PHE   A CE1 1 
ATOM   4606 C  CE2 . PHE   A 1 579 ? -24.452 -84.526  -12.811 1.00 63.25  ? 580  PHE   A CE2 1 
ATOM   4607 C  CZ  . PHE   A 1 579 ? -25.603 -84.739  -13.536 1.00 63.33  ? 580  PHE   A CZ  1 
ATOM   4608 N  N   . PRO   A 1 580 ? -20.089 -86.639  -17.768 1.00 52.17  ? 581  PRO   A N   1 
ATOM   4609 C  CA  . PRO   A 1 580 ? -18.742 -86.682  -18.334 1.00 52.14  ? 581  PRO   A CA  1 
ATOM   4610 C  C   . PRO   A 1 580 ? -17.639 -86.283  -17.342 1.00 50.74  ? 581  PRO   A C   1 
ATOM   4611 O  O   . PRO   A 1 580 ? -17.928 -85.594  -16.382 1.00 47.38  ? 581  PRO   A O   1 
ATOM   4612 C  CB  . PRO   A 1 580 ? -18.813 -85.651  -19.471 1.00 52.63  ? 581  PRO   A CB  1 
ATOM   4613 C  CG  . PRO   A 1 580 ? -20.272 -85.637  -19.869 1.00 51.57  ? 581  PRO   A CG  1 
ATOM   4614 C  CD  . PRO   A 1 580 ? -21.010 -85.813  -18.564 1.00 51.52  ? 581  PRO   A CD  1 
ATOM   4615 N  N   . ILE   A 1 581 ? -16.417 -86.755  -17.599 1.00 51.03  ? 582  ILE   A N   1 
ATOM   4616 C  CA  . ILE   A 1 581 ? -15.164 -86.285  -16.941 1.00 52.15  ? 582  ILE   A CA  1 
ATOM   4617 C  C   . ILE   A 1 581 ? -14.635 -85.101  -17.750 1.00 51.07  ? 582  ILE   A C   1 
ATOM   4618 O  O   . ILE   A 1 581 ? -14.765 -85.133  -18.986 1.00 49.60  ? 582  ILE   A O   1 
ATOM   4619 C  CB  . ILE   A 1 581 ? -14.122 -87.417  -16.849 1.00 56.05  ? 582  ILE   A CB  1 
ATOM   4620 C  CG1 . ILE   A 1 581 ? -14.625 -88.576  -15.987 1.00 59.97  ? 582  ILE   A CG1 1 
ATOM   4621 C  CG2 . ILE   A 1 581 ? -12.784 -86.896  -16.343 1.00 59.40  ? 582  ILE   A CG2 1 
ATOM   4622 C  CD1 . ILE   A 1 581 ? -14.833 -88.224  -14.530 1.00 59.66  ? 582  ILE   A CD1 1 
ATOM   4623 N  N   . LEU   A 1 582 ? -14.062 -84.104  -17.071 1.00 49.14  ? 583  LEU   A N   1 
ATOM   4624 C  CA  . LEU   A 1 582 ? -13.287 -83.008  -17.701 1.00 47.29  ? 583  LEU   A CA  1 
ATOM   4625 C  C   . LEU   A 1 582 ? -11.829 -83.112  -17.250 1.00 44.51  ? 583  LEU   A C   1 
ATOM   4626 O  O   . LEU   A 1 582 ? -11.576 -83.034  -16.037 1.00 42.86  ? 583  LEU   A O   1 
ATOM   4627 C  CB  . LEU   A 1 582 ? -13.880 -81.653  -17.303 1.00 47.84  ? 583  LEU   A CB  1 
ATOM   4628 C  CG  . LEU   A 1 582 ? -13.088 -80.439  -17.789 1.00 48.94  ? 583  LEU   A CG  1 
ATOM   4629 C  CD1 . LEU   A 1 582 ? -13.107 -80.361  -19.307 1.00 50.42  ? 583  LEU   A CD1 1 
ATOM   4630 C  CD2 . LEU   A 1 582 ? -13.631 -79.156  -17.191 1.00 50.24  ? 583  LEU   A CD2 1 
ATOM   4631 N  N   . PHE   A 1 583 ? -10.916 -83.256  -18.206 1.00 43.72  ? 584  PHE   A N   1 
ATOM   4632 C  CA  . PHE   A 1 583 ? -9.455  -83.071  -18.025 1.00 45.42  ? 584  PHE   A CA  1 
ATOM   4633 C  C   . PHE   A 1 583 ? -9.095  -81.671  -18.515 1.00 46.69  ? 584  PHE   A C   1 
ATOM   4634 O  O   . PHE   A 1 583 ? -9.097  -81.428  -19.717 1.00 45.81  ? 584  PHE   A O   1 
ATOM   4635 C  CB  . PHE   A 1 583 ? -8.685  -84.155  -18.784 1.00 45.05  ? 584  PHE   A CB  1 
ATOM   4636 C  CG  . PHE   A 1 583 ? -8.795  -85.528  -18.178 1.00 43.54  ? 584  PHE   A CG  1 
ATOM   4637 C  CD1 . PHE   A 1 583 ? -7.988  -85.896  -17.113 1.00 44.86  ? 584  PHE   A CD1 1 
ATOM   4638 C  CD2 . PHE   A 1 583 ? -9.712  -86.446  -18.657 1.00 44.45  ? 584  PHE   A CD2 1 
ATOM   4639 C  CE1 . PHE   A 1 583 ? -8.091  -87.155  -16.543 1.00 43.73  ? 584  PHE   A CE1 1 
ATOM   4640 C  CE2 . PHE   A 1 583 ? -9.812  -87.708  -18.088 1.00 46.06  ? 584  PHE   A CE2 1 
ATOM   4641 C  CZ  . PHE   A 1 583 ? -9.002  -88.060  -17.033 1.00 44.58  ? 584  PHE   A CZ  1 
ATOM   4642 N  N   . PRO   A 1 584 ? -8.843  -80.694  -17.613 1.00 49.79  ? 585  PRO   A N   1 
ATOM   4643 C  CA  . PRO   A 1 584 ? -8.457  -79.348  -18.030 1.00 49.79  ? 585  PRO   A CA  1 
ATOM   4644 C  C   . PRO   A 1 584 ? -6.987  -79.264  -18.452 1.00 50.97  ? 585  PRO   A C   1 
ATOM   4645 O  O   . PRO   A 1 584 ? -6.255  -80.180  -18.163 1.00 53.78  ? 585  PRO   A O   1 
ATOM   4646 C  CB  . PRO   A 1 584 ? -8.694  -78.468  -16.796 1.00 50.29  ? 585  PRO   A CB  1 
ATOM   4647 C  CG  . PRO   A 1 584 ? -8.773  -79.415  -15.613 1.00 50.73  ? 585  PRO   A CG  1 
ATOM   4648 C  CD  . PRO   A 1 584 ? -8.986  -80.813  -16.156 1.00 52.01  ? 585  PRO   A CD  1 
ATOM   4649 N  N   . ILE   A 1 585 ? -6.613  -78.172  -19.128 1.00 52.75  ? 586  ILE   A N   1 
ATOM   4650 C  CA  . ILE   A 1 585 ? -5.195  -77.783  -19.397 1.00 50.64  ? 586  ILE   A CA  1 
ATOM   4651 C  C   . ILE   A 1 585 ? -4.965  -76.354  -18.878 1.00 49.75  ? 586  ILE   A C   1 
ATOM   4652 O  O   . ILE   A 1 585 ? -5.873  -75.511  -19.016 1.00 47.85  ? 586  ILE   A O   1 
ATOM   4653 C  CB  . ILE   A 1 585 ? -4.839  -77.948  -20.890 1.00 49.28  ? 586  ILE   A CB  1 
ATOM   4654 C  CG1 . ILE   A 1 585 ? -5.620  -76.990  -21.792 1.00 47.88  ? 586  ILE   A CG1 1 
ATOM   4655 C  CG2 . ILE   A 1 585 ? -5.021  -79.397  -21.318 1.00 50.08  ? 586  ILE   A CG2 1 
ATOM   4656 C  CD1 . ILE   A 1 585 ? -5.260  -77.106  -23.259 1.00 48.86  ? 586  ILE   A CD1 1 
ATOM   4657 N  N   . LYS   A 1 586 ? -3.786  -76.119  -18.293 1.00 52.42  ? 587  LYS   A N   1 
ATOM   4658 C  CA  . LYS   A 1 586 ? -3.369  -74.870  -17.597 1.00 52.84  ? 587  LYS   A CA  1 
ATOM   4659 C  C   . LYS   A 1 586 ? -3.547  -73.657  -18.515 1.00 54.94  ? 587  LYS   A C   1 
ATOM   4660 O  O   . LYS   A 1 586 ? -4.077  -72.634  -18.045 1.00 57.69  ? 587  LYS   A O   1 
ATOM   4661 C  CB  . LYS   A 1 586 ? -1.902  -74.973  -17.172 1.00 52.66  ? 587  LYS   A CB  1 
ATOM   4662 C  CG  . LYS   A 1 586 ? -1.627  -75.916  -16.012 1.00 54.40  ? 587  LYS   A CG  1 
ATOM   4663 C  CD  . LYS   A 1 586 ? -0.169  -75.937  -15.610 1.00 59.01  ? 587  LYS   A CD  1 
ATOM   4664 C  CE  . LYS   A 1 586 ? 0.080   -76.590  -14.266 1.00 60.37  ? 587  LYS   A CE  1 
ATOM   4665 N  NZ  . LYS   A 1 586 ? 1.388   -76.191  -13.691 1.00 60.01  ? 587  LYS   A NZ  1 
ATOM   4666 N  N   . GLN   A 1 587 ? -3.102  -73.765  -19.769 1.00 56.07  ? 588  GLN   A N   1 
ATOM   4667 C  CA  . GLN   A 1 587 ? -3.125  -72.651  -20.747 1.00 59.26  ? 588  GLN   A CA  1 
ATOM   4668 C  C   . GLN   A 1 587 ? -3.994  -73.047  -21.933 1.00 59.42  ? 588  GLN   A C   1 
ATOM   4669 O  O   . GLN   A 1 587 ? -3.761  -74.080  -22.552 1.00 59.13  ? 588  GLN   A O   1 
ATOM   4670 C  CB  . GLN   A 1 587 ? -1.701  -72.297  -21.176 1.00 61.98  ? 588  GLN   A CB  1 
ATOM   4671 C  CG  . GLN   A 1 587 ? -0.863  -71.692  -20.054 1.00 64.22  ? 588  GLN   A CG  1 
ATOM   4672 C  CD  . GLN   A 1 587 ? -1.488  -70.465  -19.431 1.00 64.77  ? 588  GLN   A CD  1 
ATOM   4673 O  OE1 . GLN   A 1 587 ? -1.495  -70.306  -18.213 1.00 69.26  ? 588  GLN   A OE1 1 
ATOM   4674 N  NE2 . GLN   A 1 587 ? -2.030  -69.588  -20.261 1.00 64.69  ? 588  GLN   A NE2 1 
ATOM   4675 N  N   . PRO   A 1 588 ? -5.019  -72.238  -22.286 1.00 61.98  ? 589  PRO   A N   1 
ATOM   4676 C  CA  . PRO   A 1 588 ? -5.814  -72.495  -23.484 1.00 61.21  ? 589  PRO   A CA  1 
ATOM   4677 C  C   . PRO   A 1 588 ? -4.907  -72.440  -24.720 1.00 59.43  ? 589  PRO   A C   1 
ATOM   4678 O  O   . PRO   A 1 588 ? -3.973  -71.665  -24.723 1.00 61.29  ? 589  PRO   A O   1 
ATOM   4679 C  CB  . PRO   A 1 588 ? -6.867  -71.374  -23.513 1.00 62.68  ? 589  PRO   A CB  1 
ATOM   4680 C  CG  . PRO   A 1 588 ? -6.855  -70.788  -22.110 1.00 63.79  ? 589  PRO   A CG  1 
ATOM   4681 C  CD  . PRO   A 1 588 ? -5.457  -71.026  -21.575 1.00 63.83  ? 589  PRO   A CD  1 
ATOM   4682 N  N   . ILE   A 1 589 ? -5.190  -73.271  -25.720 1.00 60.21  ? 590  ILE   A N   1 
ATOM   4683 C  CA  . ILE   A 1 589 ? -4.378  -73.378  -26.966 1.00 59.84  ? 590  ILE   A CA  1 
ATOM   4684 C  C   . ILE   A 1 589 ? -5.266  -72.993  -28.147 1.00 61.23  ? 590  ILE   A C   1 
ATOM   4685 O  O   . ILE   A 1 589 ? -6.293  -73.675  -28.354 1.00 60.02  ? 590  ILE   A O   1 
ATOM   4686 C  CB  . ILE   A 1 589 ? -3.799  -74.796  -27.129 1.00 60.53  ? 590  ILE   A CB  1 
ATOM   4687 C  CG1 . ILE   A 1 589 ? -2.834  -75.143  -25.993 1.00 60.78  ? 590  ILE   A CG1 1 
ATOM   4688 C  CG2 . ILE   A 1 589 ? -3.149  -74.950  -28.497 1.00 63.27  ? 590  ILE   A CG2 1 
ATOM   4689 C  CD1 . ILE   A 1 589 ? -2.396  -76.587  -25.973 1.00 61.78  ? 590  ILE   A CD1 1 
ATOM   4690 N  N   . THR   A 1 590 ? -4.880  -71.948  -28.883 1.00 61.25  ? 591  THR   A N   1 
ATOM   4691 C  CA  . THR   A 1 590 ? -5.548  -71.527  -30.139 1.00 61.54  ? 591  THR   A CA  1 
ATOM   4692 C  C   . THR   A 1 590 ? -5.391  -72.658  -31.156 1.00 60.09  ? 591  THR   A C   1 
ATOM   4693 O  O   . THR   A 1 590 ? -4.265  -73.169  -31.297 1.00 58.37  ? 591  THR   A O   1 
ATOM   4694 C  CB  . THR   A 1 590 ? -4.994  -70.194  -30.656 1.00 63.76  ? 591  THR   A CB  1 
ATOM   4695 O  OG1 . THR   A 1 590 ? -5.346  -69.203  -29.691 1.00 66.07  ? 591  THR   A OG1 1 
ATOM   4696 C  CG2 . THR   A 1 590 ? -5.537  -69.811  -32.016 1.00 63.63  ? 591  THR   A CG2 1 
ATOM   4697 N  N   . VAL   A 1 591 ? -6.490  -73.036  -31.809 1.00 58.68  ? 592  VAL   A N   1 
ATOM   4698 C  CA  . VAL   A 1 591 ? -6.535  -74.080  -32.872 1.00 59.17  ? 592  VAL   A CA  1 
ATOM   4699 C  C   . VAL   A 1 591 ? -7.226  -73.475  -34.100 1.00 62.01  ? 592  VAL   A C   1 
ATOM   4700 O  O   . VAL   A 1 591 ? -8.359  -72.977  -33.956 1.00 64.09  ? 592  VAL   A O   1 
ATOM   4701 C  CB  . VAL   A 1 591 ? -7.254  -75.343  -32.365 1.00 58.64  ? 592  VAL   A CB  1 
ATOM   4702 C  CG1 . VAL   A 1 591 ? -7.364  -76.414  -33.440 1.00 58.24  ? 592  VAL   A CG1 1 
ATOM   4703 C  CG2 . VAL   A 1 591 ? -6.583  -75.900  -31.120 1.00 58.29  ? 592  VAL   A CG2 1 
ATOM   4704 N  N   . ARG   A 1 592 ? -6.550  -73.499  -35.251 1.00 66.24  ? 593  ARG   A N   1 
ATOM   4705 C  CA  . ARG   A 1 592 ? -7.071  -72.999  -36.549 1.00 70.62  ? 593  ARG   A CA  1 
ATOM   4706 C  C   . ARG   A 1 592 ? -7.748  -74.152  -37.291 1.00 71.02  ? 593  ARG   A C   1 
ATOM   4707 O  O   . ARG   A 1 592 ? -7.304  -75.301  -37.113 1.00 68.27  ? 593  ARG   A O   1 
ATOM   4708 C  CB  . ARG   A 1 592 ? -5.933  -72.432  -37.400 1.00 76.67  ? 593  ARG   A CB  1 
ATOM   4709 C  CG  . ARG   A 1 592 ? -5.268  -71.196  -36.815 1.00 87.28  ? 593  ARG   A CG  1 
ATOM   4710 C  CD  . ARG   A 1 592 ? -3.932  -70.875  -37.467 1.00 96.53  ? 593  ARG   A CD  1 
ATOM   4711 N  NE  . ARG   A 1 592 ? -3.976  -70.874  -38.928 1.00 104.01 ? 593  ARG   A NE  1 
ATOM   4712 C  CZ  . ARG   A 1 592 ? -3.066  -70.317  -39.729 1.00 111.20 ? 593  ARG   A CZ  1 
ATOM   4713 N  NH1 . ARG   A 1 592 ? -2.013  -69.686  -39.231 1.00 112.64 ? 593  ARG   A NH1 1 
ATOM   4714 N  NH2 . ARG   A 1 592 ? -3.219  -70.386  -41.041 1.00 113.83 ? 593  ARG   A NH2 1 
ATOM   4715 N  N   . GLU   A 1 593 ? -8.760  -73.857  -38.114 1.00 69.45  ? 594  GLU   A N   1 
ATOM   4716 C  CA  . GLU   A 1 593 ? -9.464  -74.882  -38.929 1.00 73.70  ? 594  GLU   A CA  1 
ATOM   4717 C  C   . GLU   A 1 593 ? -8.415  -75.662  -39.730 1.00 68.69  ? 594  GLU   A C   1 
ATOM   4718 O  O   . GLU   A 1 593 ? -7.398  -75.058  -40.122 1.00 67.61  ? 594  GLU   A O   1 
ATOM   4719 C  CB  . GLU   A 1 593 ? -10.535 -74.259  -39.832 1.00 81.70  ? 594  GLU   A CB  1 
ATOM   4720 C  CG  . GLU   A 1 593 ? -9.987  -73.560  -41.068 1.00 89.35  ? 594  GLU   A CG  1 
ATOM   4721 C  CD  . GLU   A 1 593 ? -10.979 -73.370  -42.202 1.00 94.03  ? 594  GLU   A CD  1 
ATOM   4722 O  OE1 . GLU   A 1 593 ? -12.011 -74.077  -42.219 1.00 90.61  ? 594  GLU   A OE1 1 
ATOM   4723 O  OE2 . GLU   A 1 593 ? -10.707 -72.517  -43.075 1.00 102.97 ? 594  GLU   A OE2 1 
ATOM   4724 N  N   . GLY   A 1 594 ? -8.645  -76.961  -39.926 1.00 67.97  ? 595  GLY   A N   1 
ATOM   4725 C  CA  . GLY   A 1 594 ? -7.761  -77.858  -40.693 1.00 68.03  ? 595  GLY   A CA  1 
ATOM   4726 C  C   . GLY   A 1 594 ? -6.632  -78.423  -39.850 1.00 68.39  ? 595  GLY   A C   1 
ATOM   4727 O  O   . GLY   A 1 594 ? -6.028  -79.418  -40.287 1.00 74.73  ? 595  GLY   A O   1 
ATOM   4728 N  N   . GLN   A 1 595 ? -6.350  -77.826  -38.686 1.00 64.79  ? 596  GLN   A N   1 
ATOM   4729 C  CA  . GLN   A 1 595 ? -5.277  -78.280  -37.765 1.00 63.25  ? 596  GLN   A CA  1 
ATOM   4730 C  C   . GLN   A 1 595 ? -5.730  -79.539  -37.014 1.00 65.10  ? 596  GLN   A C   1 
ATOM   4731 O  O   . GLN   A 1 595 ? -6.954  -79.738  -36.839 1.00 67.02  ? 596  GLN   A O   1 
ATOM   4732 C  CB  . GLN   A 1 595 ? -4.894  -77.181  -36.776 1.00 61.63  ? 596  GLN   A CB  1 
ATOM   4733 C  CG  . GLN   A 1 595 ? -4.149  -76.023  -37.420 1.00 63.29  ? 596  GLN   A CG  1 
ATOM   4734 C  CD  . GLN   A 1 595 ? -3.478  -75.139  -36.396 1.00 62.64  ? 596  GLN   A CD  1 
ATOM   4735 O  OE1 . GLN   A 1 595 ? -4.076  -74.752  -35.393 1.00 62.53  ? 596  GLN   A OE1 1 
ATOM   4736 N  NE2 . GLN   A 1 595 ? -2.223  -74.803  -36.643 1.00 61.05  ? 596  GLN   A NE2 1 
ATOM   4737 N  N   . THR   A 1 596 ? -4.754  -80.346  -36.592 1.00 62.30  ? 597  THR   A N   1 
ATOM   4738 C  CA  . THR   A 1 596 ? -4.916  -81.569  -35.768 1.00 61.69  ? 597  THR   A CA  1 
ATOM   4739 C  C   . THR   A 1 596 ? -4.552  -81.231  -34.318 1.00 60.93  ? 597  THR   A C   1 
ATOM   4740 O  O   . THR   A 1 596 ? -3.462  -80.665  -34.100 1.00 63.10  ? 597  THR   A O   1 
ATOM   4741 C  CB  . THR   A 1 596 ? -4.050  -82.704  -36.330 1.00 63.64  ? 597  THR   A CB  1 
ATOM   4742 O  OG1 . THR   A 1 596 ? -4.762  -83.271  -37.430 1.00 63.95  ? 597  THR   A OG1 1 
ATOM   4743 C  CG2 . THR   A 1 596 ? -3.721  -83.783  -35.320 1.00 65.22  ? 597  THR   A CG2 1 
ATOM   4744 N  N   . ILE   A 1 597 ? -5.441  -81.540  -33.373 1.00 57.80  ? 598  ILE   A N   1 
ATOM   4745 C  CA  . ILE   A 1 597 ? -5.119  -81.551  -31.918 1.00 55.43  ? 598  ILE   A CA  1 
ATOM   4746 C  C   . ILE   A 1 597 ? -4.575  -82.939  -31.591 1.00 53.75  ? 598  ILE   A C   1 
ATOM   4747 O  O   . ILE   A 1 597 ? -5.351  -83.905  -31.686 1.00 47.93  ? 598  ILE   A O   1 
ATOM   4748 C  CB  . ILE   A 1 597 ? -6.339  -81.207  -31.045 1.00 54.54  ? 598  ILE   A CB  1 
ATOM   4749 C  CG1 . ILE   A 1 597 ? -6.734  -79.735  -31.183 1.00 55.28  ? 598  ILE   A CG1 1 
ATOM   4750 C  CG2 . ILE   A 1 597 ? -6.076  -81.587  -29.595 1.00 54.25  ? 598  ILE   A CG2 1 
ATOM   4751 C  CD1 . ILE   A 1 597 ? -8.090  -79.413  -30.596 1.00 56.37  ? 598  ILE   A CD1 1 
ATOM   4752 N  N   . CYS   A 1 598 ? -3.291  -83.024  -31.243 1.00 53.93  ? 599  CYS   A N   1 
ATOM   4753 C  CA  . CYS   A 1 598 ? -2.654  -84.257  -30.716 1.00 53.88  ? 599  CYS   A CA  1 
ATOM   4754 C  C   . CYS   A 1 598 ? -2.621  -84.190  -29.187 1.00 50.37  ? 599  CYS   A C   1 
ATOM   4755 O  O   . CYS   A 1 598 ? -1.999  -83.258  -28.653 1.00 50.43  ? 599  CYS   A O   1 
ATOM   4756 C  CB  . CYS   A 1 598 ? -1.244  -84.450  -31.260 1.00 54.52  ? 599  CYS   A CB  1 
ATOM   4757 S  SG  . CYS   A 1 598 ? -0.568  -86.076  -30.844 1.00 55.58  ? 599  CYS   A SG  1 
ATOM   4758 N  N   . VAL   A 1 599 ? -3.286  -85.128  -28.515 1.00 49.76  ? 600  VAL   A N   1 
ATOM   4759 C  CA  . VAL   A 1 599 ? -3.202  -85.278  -27.034 1.00 51.54  ? 600  VAL   A CA  1 
ATOM   4760 C  C   . VAL   A 1 599 ? -2.604  -86.649  -26.707 1.00 52.39  ? 600  VAL   A C   1 
ATOM   4761 O  O   . VAL   A 1 599 ? -2.787  -87.607  -27.495 1.00 49.95  ? 600  VAL   A O   1 
ATOM   4762 C  CB  . VAL   A 1 599 ? -4.561  -85.078  -26.344 1.00 52.63  ? 600  VAL   A CB  1 
ATOM   4763 C  CG1 . VAL   A 1 599 ? -5.508  -86.237  -26.608 1.00 53.76  ? 600  VAL   A CG1 1 
ATOM   4764 C  CG2 . VAL   A 1 599 ? -4.390  -84.851  -24.850 1.00 53.91  ? 600  VAL   A CG2 1 
ATOM   4765 N  N   . ARG   A 1 600 ? -1.889  -86.703  -25.585 1.00 52.50  ? 601  ARG   A N   1 
ATOM   4766 C  CA  . ARG   A 1 600 ? -1.205  -87.903  -25.053 1.00 50.99  ? 601  ARG   A CA  1 
ATOM   4767 C  C   . ARG   A 1 600 ? -1.726  -88.124  -23.636 1.00 50.10  ? 601  ARG   A C   1 
ATOM   4768 O  O   . ARG   A 1 600 ? -1.612  -87.187  -22.830 1.00 53.79  ? 601  ARG   A O   1 
ATOM   4769 C  CB  . ARG   A 1 600 ? 0.308   -87.673  -25.063 1.00 52.86  ? 601  ARG   A CB  1 
ATOM   4770 C  CG  . ARG   A 1 600 ? 0.836   -87.050  -26.348 1.00 56.21  ? 601  ARG   A CG  1 
ATOM   4771 C  CD  . ARG   A 1 600 ? 1.650   -87.991  -27.216 1.00 55.87  ? 601  ARG   A CD  1 
ATOM   4772 N  NE  . ARG   A 1 600 ? 2.201   -87.291  -28.372 1.00 55.78  ? 601  ARG   A NE  1 
ATOM   4773 C  CZ  . ARG   A 1 600 ? 3.144   -87.767  -29.180 1.00 55.33  ? 601  ARG   A CZ  1 
ATOM   4774 N  NH1 . ARG   A 1 600 ? 3.668   -88.961  -28.968 1.00 55.06  ? 601  ARG   A NH1 1 
ATOM   4775 N  NH2 . ARG   A 1 600 ? 3.572   -87.036  -30.194 1.00 56.01  ? 601  ARG   A NH2 1 
ATOM   4776 N  N   . PHE   A 1 601 ? -2.320  -89.287  -23.366 1.00 48.99  ? 602  PHE   A N   1 
ATOM   4777 C  CA  . PHE   A 1 601 ? -2.775  -89.697  -22.014 1.00 48.64  ? 602  PHE   A CA  1 
ATOM   4778 C  C   . PHE   A 1 601 ? -1.938  -90.883  -21.539 1.00 49.86  ? 602  PHE   A C   1 
ATOM   4779 O  O   . PHE   A 1 601 ? -1.684  -91.819  -22.332 1.00 50.78  ? 602  PHE   A O   1 
ATOM   4780 C  CB  . PHE   A 1 601 ? -4.275  -89.999  -22.004 1.00 49.11  ? 602  PHE   A CB  1 
ATOM   4781 C  CG  . PHE   A 1 601 ? -5.118  -88.815  -21.608 1.00 48.94  ? 602  PHE   A CG  1 
ATOM   4782 C  CD1 . PHE   A 1 601 ? -5.220  -87.714  -22.445 1.00 47.45  ? 602  PHE   A CD1 1 
ATOM   4783 C  CD2 . PHE   A 1 601 ? -5.772  -88.784  -20.385 1.00 49.42  ? 602  PHE   A CD2 1 
ATOM   4784 C  CE1 . PHE   A 1 601 ? -5.987  -86.619  -22.080 1.00 48.66  ? 602  PHE   A CE1 1 
ATOM   4785 C  CE2 . PHE   A 1 601 ? -6.532  -87.684  -20.017 1.00 48.79  ? 602  PHE   A CE2 1 
ATOM   4786 C  CZ  . PHE   A 1 601 ? -6.641  -86.608  -20.868 1.00 50.41  ? 602  PHE   A CZ  1 
ATOM   4787 N  N   . TRP   A 1 602 ? -1.530  -90.826  -20.270 1.00 49.78  ? 603  TRP   A N   1 
ATOM   4788 C  CA  . TRP   A 1 602 ? -0.826  -91.913  -19.545 1.00 49.19  ? 603  TRP   A CA  1 
ATOM   4789 C  C   . TRP   A 1 602 ? -1.697  -92.380  -18.379 1.00 50.00  ? 603  TRP   A C   1 
ATOM   4790 O  O   . TRP   A 1 602 ? -2.239  -91.512  -17.669 1.00 50.66  ? 603  TRP   A O   1 
ATOM   4791 C  CB  . TRP   A 1 602 ? 0.532   -91.435  -19.030 1.00 48.67  ? 603  TRP   A CB  1 
ATOM   4792 C  CG  . TRP   A 1 602 ? 1.544   -91.113  -20.083 1.00 48.88  ? 603  TRP   A CG  1 
ATOM   4793 C  CD1 . TRP   A 1 602 ? 2.466   -91.963  -20.618 1.00 47.65  ? 603  TRP   A CD1 1 
ATOM   4794 C  CD2 . TRP   A 1 602 ? 1.779   -89.831  -20.692 1.00 50.83  ? 603  TRP   A CD2 1 
ATOM   4795 N  NE1 . TRP   A 1 602 ? 3.247   -91.305  -21.528 1.00 48.58  ? 603  TRP   A NE1 1 
ATOM   4796 C  CE2 . TRP   A 1 602 ? 2.848   -89.996  -21.598 1.00 50.23  ? 603  TRP   A CE2 1 
ATOM   4797 C  CE3 . TRP   A 1 602 ? 1.185   -88.569  -20.576 1.00 50.08  ? 603  TRP   A CE3 1 
ATOM   4798 C  CZ2 . TRP   A 1 602 ? 3.340   -88.943  -22.368 1.00 50.29  ? 603  TRP   A CZ2 1 
ATOM   4799 C  CZ3 . TRP   A 1 602 ? 1.672   -87.530  -21.339 1.00 51.07  ? 603  TRP   A CZ3 1 
ATOM   4800 C  CH2 . TRP   A 1 602 ? 2.733   -87.716  -22.224 1.00 49.90  ? 603  TRP   A CH2 1 
ATOM   4801 N  N   . ARG   A 1 603 ? -1.823  -93.697  -18.196 1.00 48.65  ? 604  ARG   A N   1 
ATOM   4802 C  CA  . ARG   A 1 603 ? -2.267  -94.310  -16.917 1.00 48.06  ? 604  ARG   A CA  1 
ATOM   4803 C  C   . ARG   A 1 603 ? -1.003  -94.800  -16.212 1.00 45.69  ? 604  ARG   A C   1 
ATOM   4804 O  O   . ARG   A 1 603 ? -0.267  -95.595  -16.813 1.00 44.30  ? 604  ARG   A O   1 
ATOM   4805 C  CB  . ARG   A 1 603 ? -3.282  -95.432  -17.149 1.00 48.02  ? 604  ARG   A CB  1 
ATOM   4806 C  CG  . ARG   A 1 603 ? -4.102  -95.800  -15.920 1.00 47.49  ? 604  ARG   A CG  1 
ATOM   4807 C  CD  . ARG   A 1 603 ? -5.143  -96.842  -16.285 1.00 47.39  ? 604  ARG   A CD  1 
ATOM   4808 N  NE  . ARG   A 1 603 ? -6.101  -97.158  -15.234 1.00 48.45  ? 604  ARG   A NE  1 
ATOM   4809 C  CZ  . ARG   A 1 603 ? -5.925  -98.045  -14.258 1.00 49.70  ? 604  ARG   A CZ  1 
ATOM   4810 N  NH1 . ARG   A 1 603 ? -4.797  -98.728  -14.150 1.00 51.34  ? 604  ARG   A NH1 1 
ATOM   4811 N  NH2 . ARG   A 1 603 ? -6.889  -98.241  -13.378 1.00 51.99  ? 604  ARG   A NH2 1 
ATOM   4812 N  N   . CYS   A 1 604 ? -0.752  -94.287  -15.010 1.00 46.57  ? 605  CYS   A N   1 
ATOM   4813 C  CA  . CYS   A 1 604 ? 0.487   -94.500  -14.221 1.00 47.87  ? 605  CYS   A CA  1 
ATOM   4814 C  C   . CYS   A 1 604 ? 0.107   -95.043  -12.848 1.00 49.88  ? 605  CYS   A C   1 
ATOM   4815 O  O   . CYS   A 1 604 ? -1.056  -94.849  -12.441 1.00 49.59  ? 605  CYS   A O   1 
ATOM   4816 C  CB  . CYS   A 1 604 ? 1.254   -93.195  -14.082 1.00 48.33  ? 605  CYS   A CB  1 
ATOM   4817 S  SG  . CYS   A 1 604 ? 1.683   -92.466  -15.682 1.00 50.95  ? 605  CYS   A SG  1 
ATOM   4818 N  N   . SER   A 1 605 ? 1.044   -95.696  -12.161 1.00 52.49  ? 606  SER   A N   1 
ATOM   4819 C  CA  . SER   A 1 605 ? 0.763   -96.364  -10.868 1.00 53.46  ? 606  SER   A CA  1 
ATOM   4820 C  C   . SER   A 1 605 ? 2.042   -96.750  -10.127 1.00 57.94  ? 606  SER   A C   1 
ATOM   4821 O  O   . SER   A 1 605 ? 3.118   -96.834  -10.751 1.00 58.83  ? 606  SER   A O   1 
ATOM   4822 C  CB  . SER   A 1 605 ? -0.087  -97.575  -11.096 1.00 53.07  ? 606  SER   A CB  1 
ATOM   4823 O  OG  . SER   A 1 605 ? 0.551   -98.456  -12.004 1.00 52.93  ? 606  SER   A OG  1 
ATOM   4824 N  N   . ASN   A 1 606 ? 1.882   -96.974  -8.824  1.00 61.71  ? 607  ASN   A N   1 
ATOM   4825 C  CA  . ASN   A 1 606 ? 2.790   -97.773  -7.965  1.00 60.98  ? 607  ASN   A CA  1 
ATOM   4826 C  C   . ASN   A 1 606 ? 1.896   -98.641  -7.067  1.00 62.42  ? 607  ASN   A C   1 
ATOM   4827 O  O   . ASN   A 1 606 ? 0.688   -98.746  -7.366  1.00 57.91  ? 607  ASN   A O   1 
ATOM   4828 C  CB  . ASN   A 1 606 ? 3.782   -96.869  -7.231  1.00 61.08  ? 607  ASN   A CB  1 
ATOM   4829 C  CG  . ASN   A 1 606 ? 3.113   -95.819  -6.374  1.00 60.23  ? 607  ASN   A CG  1 
ATOM   4830 O  OD1 . ASN   A 1 606 ? 2.092   -96.081  -5.749  1.00 62.48  ? 607  ASN   A OD1 1 
ATOM   4831 N  ND2 . ASN   A 1 606 ? 3.692   -94.633  -6.320  1.00 63.18  ? 607  ASN   A ND2 1 
ATOM   4832 N  N   . SER   A 1 607 ? 2.454   -99.245  -6.017  1.00 65.50  ? 608  SER   A N   1 
ATOM   4833 C  CA  . SER   A 1 607 ? 1.740   -100.183 -5.110  1.00 68.68  ? 608  SER   A CA  1 
ATOM   4834 C  C   . SER   A 1 607 ? 0.570   -99.485  -4.398  1.00 68.53  ? 608  SER   A C   1 
ATOM   4835 O  O   . SER   A 1 607 ? -0.354  -100.198 -3.968  1.00 70.00  ? 608  SER   A O   1 
ATOM   4836 C  CB  . SER   A 1 607 ? 2.694   -100.783 -4.114  1.00 68.38  ? 608  SER   A CB  1 
ATOM   4837 O  OG  . SER   A 1 607 ? 3.453   -99.767  -3.477  1.00 72.84  ? 608  SER   A OG  1 
ATOM   4838 N  N   . LYS   A 1 608 ? 0.605   -98.152  -4.286  1.00 67.15  ? 609  LYS   A N   1 
ATOM   4839 C  CA  . LYS   A 1 608 ? -0.265  -97.367  -3.371  1.00 68.79  ? 609  LYS   A CA  1 
ATOM   4840 C  C   . LYS   A 1 608 ? -1.333  -96.572  -4.130  1.00 65.02  ? 609  LYS   A C   1 
ATOM   4841 O  O   . LYS   A 1 608 ? -2.428  -96.395  -3.567  1.00 62.88  ? 609  LYS   A O   1 
ATOM   4842 C  CB  . LYS   A 1 608 ? 0.606   -96.430  -2.532  1.00 72.38  ? 609  LYS   A CB  1 
ATOM   4843 C  CG  . LYS   A 1 608 ? 1.338   -97.119  -1.391  1.00 75.91  ? 609  LYS   A CG  1 
ATOM   4844 C  CD  . LYS   A 1 608 ? 2.536   -96.353  -0.910  1.00 77.72  ? 609  LYS   A CD  1 
ATOM   4845 C  CE  . LYS   A 1 608 ? 3.067   -96.871  0.405   1.00 82.85  ? 609  LYS   A CE  1 
ATOM   4846 N  NZ  . LYS   A 1 608 ? 4.008   -95.903  1.018   1.00 86.94  ? 609  LYS   A NZ  1 
ATOM   4847 N  N   . LYS   A 1 609 ? -1.036  -96.092  -5.340  1.00 66.77  ? 610  LYS   A N   1 
ATOM   4848 C  CA  . LYS   A 1 609 ? -1.913  -95.127  -6.057  1.00 65.02  ? 610  LYS   A CA  1 
ATOM   4849 C  C   . LYS   A 1 609 ? -1.788  -95.294  -7.576  1.00 60.18  ? 610  LYS   A C   1 
ATOM   4850 O  O   . LYS   A 1 609 ? -0.706  -95.674  -8.059  1.00 60.62  ? 610  LYS   A O   1 
ATOM   4851 C  CB  . LYS   A 1 609 ? -1.578  -93.701  -5.608  1.00 70.60  ? 610  LYS   A CB  1 
ATOM   4852 C  CG  . LYS   A 1 609 ? -0.119  -93.292  -5.756  1.00 75.58  ? 610  LYS   A CG  1 
ATOM   4853 C  CD  . LYS   A 1 609 ? 0.316   -92.167  -4.829  1.00 79.48  ? 610  LYS   A CD  1 
ATOM   4854 C  CE  . LYS   A 1 609 ? 1.767   -91.773  -5.036  1.00 80.71  ? 610  LYS   A CE  1 
ATOM   4855 N  NZ  . LYS   A 1 609 ? 2.048   -90.389  -4.587  1.00 79.68  ? 610  LYS   A NZ  1 
ATOM   4856 N  N   . VAL   A 1 610 ? -2.890  -95.034  -8.278  1.00 55.77  ? 611  VAL   A N   1 
ATOM   4857 C  CA  . VAL   A 1 610 ? -2.990  -94.939  -9.763  1.00 54.29  ? 611  VAL   A CA  1 
ATOM   4858 C  C   . VAL   A 1 610 ? -3.290  -93.474  -10.086 1.00 52.50  ? 611  VAL   A C   1 
ATOM   4859 O  O   . VAL   A 1 610 ? -3.913  -92.804  -9.241  1.00 54.65  ? 611  VAL   A O   1 
ATOM   4860 C  CB  . VAL   A 1 610 ? -4.094  -95.877  -10.293 1.00 55.86  ? 611  VAL   A CB  1 
ATOM   4861 C  CG1 . VAL   A 1 610 ? -4.369  -95.685  -11.778 1.00 55.69  ? 611  VAL   A CG1 1 
ATOM   4862 C  CG2 . VAL   A 1 610 ? -3.783  -97.333  -9.991  1.00 56.15  ? 611  VAL   A CG2 1 
ATOM   4863 N  N   . TRP   A 1 611 ? -2.869  -92.986  -11.250 1.00 49.13  ? 612  TRP   A N   1 
ATOM   4864 C  CA  . TRP   A 1 611 ? -3.190  -91.604  -11.693 1.00 48.11  ? 612  TRP   A CA  1 
ATOM   4865 C  C   . TRP   A 1 611 ? -3.061  -91.498  -13.212 1.00 46.61  ? 612  TRP   A C   1 
ATOM   4866 O  O   . TRP   A 1 611 ? -2.580  -92.450  -13.837 1.00 46.61  ? 612  TRP   A O   1 
ATOM   4867 C  CB  . TRP   A 1 611 ? -2.313  -90.575  -10.959 1.00 48.26  ? 612  TRP   A CB  1 
ATOM   4868 C  CG  . TRP   A 1 611 ? -0.855  -90.641  -11.292 1.00 48.33  ? 612  TRP   A CG  1 
ATOM   4869 C  CD1 . TRP   A 1 611 ? -0.199  -89.920  -12.248 1.00 49.90  ? 612  TRP   A CD1 1 
ATOM   4870 C  CD2 . TRP   A 1 611 ? 0.136   -91.479  -10.672 1.00 48.99  ? 612  TRP   A CD2 1 
ATOM   4871 N  NE1 . TRP   A 1 611 ? 1.128   -90.251  -12.266 1.00 51.20  ? 612  TRP   A NE1 1 
ATOM   4872 C  CE2 . TRP   A 1 611 ? 1.364   -91.206  -11.311 1.00 50.06  ? 612  TRP   A CE2 1 
ATOM   4873 C  CE3 . TRP   A 1 611 ? 0.107   -92.435  -9.650  1.00 50.82  ? 612  TRP   A CE3 1 
ATOM   4874 C  CZ2 . TRP   A 1 611 ? 2.546   -91.855  -10.959 1.00 48.68  ? 612  TRP   A CZ2 1 
ATOM   4875 C  CZ3 . TRP   A 1 611 ? 1.278   -93.071  -9.298  1.00 50.68  ? 612  TRP   A CZ3 1 
ATOM   4876 C  CH2 . TRP   A 1 611 ? 2.478   -92.785  -9.948  1.00 49.55  ? 612  TRP   A CH2 1 
ATOM   4877 N  N   . TYR   A 1 612 ? -3.530  -90.382  -13.766 1.00 48.22  ? 613  TYR   A N   1 
ATOM   4878 C  CA  . TYR   A 1 612 ? -3.364  -89.995  -15.186 1.00 48.08  ? 613  TYR   A CA  1 
ATOM   4879 C  C   . TYR   A 1 612 ? -2.378  -88.824  -15.264 1.00 48.03  ? 613  TYR   A C   1 
ATOM   4880 O  O   . TYR   A 1 612 ? -2.370  -87.959  -14.373 1.00 47.76  ? 613  TYR   A O   1 
ATOM   4881 C  CB  . TYR   A 1 612 ? -4.716  -89.637  -15.807 1.00 49.46  ? 613  TYR   A CB  1 
ATOM   4882 C  CG  . TYR   A 1 612 ? -5.775  -90.704  -15.683 1.00 51.86  ? 613  TYR   A CG  1 
ATOM   4883 C  CD1 . TYR   A 1 612 ? -5.721  -91.864  -16.439 1.00 52.90  ? 613  TYR   A CD1 1 
ATOM   4884 C  CD2 . TYR   A 1 612 ? -6.843  -90.552  -14.816 1.00 53.06  ? 613  TYR   A CD2 1 
ATOM   4885 C  CE1 . TYR   A 1 612 ? -6.695  -92.845  -16.329 1.00 51.76  ? 613  TYR   A CE1 1 
ATOM   4886 C  CE2 . TYR   A 1 612 ? -7.827  -91.521  -14.696 1.00 50.79  ? 613  TYR   A CE2 1 
ATOM   4887 C  CZ  . TYR   A 1 612 ? -7.754  -92.672  -15.455 1.00 50.96  ? 613  TYR   A CZ  1 
ATOM   4888 O  OH  . TYR   A 1 612 ? -8.724  -93.623  -15.328 1.00 50.42  ? 613  TYR   A OH  1 
ATOM   4889 N  N   . GLU   A 1 613 ? -1.528  -88.845  -16.287 1.00 49.85  ? 614  GLU   A N   1 
ATOM   4890 C  CA  . GLU   A 1 613 ? -0.776  -87.677  -16.804 1.00 49.15  ? 614  GLU   A CA  1 
ATOM   4891 C  C   . GLU   A 1 613 ? -1.265  -87.444  -18.234 1.00 49.85  ? 614  GLU   A C   1 
ATOM   4892 O  O   . GLU   A 1 613 ? -1.711  -88.415  -18.871 1.00 50.62  ? 614  GLU   A O   1 
ATOM   4893 C  CB  . GLU   A 1 613 ? 0.729   -87.933  -16.749 1.00 47.99  ? 614  GLU   A CB  1 
ATOM   4894 C  CG  . GLU   A 1 613 ? 1.194   -88.493  -15.418 1.00 48.99  ? 614  GLU   A CG  1 
ATOM   4895 C  CD  . GLU   A 1 613 ? 2.699   -88.583  -15.230 1.00 50.64  ? 614  GLU   A CD  1 
ATOM   4896 O  OE1 . GLU   A 1 613 ? 3.442   -87.980  -16.027 1.00 53.73  ? 614  GLU   A OE1 1 
ATOM   4897 O  OE2 . GLU   A 1 613 ? 3.127   -89.258  -14.284 1.00 53.57  ? 614  GLU   A OE2 1 
ATOM   4898 N  N   . TRP   A 1 614 ? -1.224  -86.203  -18.711 1.00 50.60  ? 615  TRP   A N   1 
ATOM   4899 C  CA  . TRP   A 1 614 ? -1.622  -85.872  -20.101 1.00 48.60  ? 615  TRP   A CA  1 
ATOM   4900 C  C   . TRP   A 1 614 ? -0.830  -84.663  -20.597 1.00 48.12  ? 615  TRP   A C   1 
ATOM   4901 O  O   . TRP   A 1 614 ? -0.361  -83.870  -19.756 1.00 45.89  ? 615  TRP   A O   1 
ATOM   4902 C  CB  . TRP   A 1 614 ? -3.138  -85.671  -20.208 1.00 48.85  ? 615  TRP   A CB  1 
ATOM   4903 C  CG  . TRP   A 1 614 ? -3.725  -84.604  -19.335 1.00 49.55  ? 615  TRP   A CG  1 
ATOM   4904 C  CD1 . TRP   A 1 614 ? -4.066  -83.341  -19.719 1.00 51.22  ? 615  TRP   A CD1 1 
ATOM   4905 C  CD2 . TRP   A 1 614 ? -4.105  -84.716  -17.950 1.00 50.18  ? 615  TRP   A CD2 1 
ATOM   4906 N  NE1 . TRP   A 1 614 ? -4.617  -82.654  -18.670 1.00 52.23  ? 615  TRP   A NE1 1 
ATOM   4907 C  CE2 . TRP   A 1 614 ? -4.652  -83.468  -17.571 1.00 50.79  ? 615  TRP   A CE2 1 
ATOM   4908 C  CE3 . TRP   A 1 614 ? -4.031  -85.733  -16.991 1.00 49.04  ? 615  TRP   A CE3 1 
ATOM   4909 C  CZ2 . TRP   A 1 614 ? -5.116  -83.216  -16.281 1.00 49.08  ? 615  TRP   A CZ2 1 
ATOM   4910 C  CZ3 . TRP   A 1 614 ? -4.491  -85.485  -15.717 1.00 48.30  ? 615  TRP   A CZ3 1 
ATOM   4911 C  CH2 . TRP   A 1 614 ? -5.026  -84.243  -15.369 1.00 49.80  ? 615  TRP   A CH2 1 
ATOM   4912 N  N   . ALA   A 1 615 ? -0.655  -84.578  -21.916 1.00 47.34  ? 616  ALA   A N   1 
ATOM   4913 C  CA  . ALA   A 1 615 ? -0.014  -83.446  -22.616 1.00 48.91  ? 616  ALA   A CA  1 
ATOM   4914 C  C   . ALA   A 1 615 ? -0.635  -83.304  -24.004 1.00 51.27  ? 616  ALA   A C   1 
ATOM   4915 O  O   . ALA   A 1 615 ? -0.940  -84.342  -24.618 1.00 55.09  ? 616  ALA   A O   1 
ATOM   4916 C  CB  . ALA   A 1 615 ? 1.472   -83.666  -22.706 1.00 50.15  ? 616  ALA   A CB  1 
ATOM   4917 N  N   . VAL   A 1 616 ? -0.835  -82.061  -24.449 1.00 51.81  ? 617  VAL   A N   1 
ATOM   4918 C  CA  . VAL   A 1 616 ? -1.112  -81.715  -25.872 1.00 51.84  ? 617  VAL   A CA  1 
ATOM   4919 C  C   . VAL   A 1 616 ? 0.255   -81.539  -26.532 1.00 52.47  ? 617  VAL   A C   1 
ATOM   4920 O  O   . VAL   A 1 616 ? 1.112   -80.899  -25.894 1.00 54.93  ? 617  VAL   A O   1 
ATOM   4921 C  CB  . VAL   A 1 616 ? -1.977  -80.446  -25.993 1.00 51.17  ? 617  VAL   A CB  1 
ATOM   4922 C  CG1 . VAL   A 1 616 ? -2.292  -80.101  -27.442 1.00 49.76  ? 617  VAL   A CG1 1 
ATOM   4923 C  CG2 . VAL   A 1 616 ? -3.258  -80.557  -25.184 1.00 49.83  ? 617  VAL   A CG2 1 
ATOM   4924 N  N   . THR   A 1 617 ? 0.462   -82.122  -27.718 1.00 52.35  ? 618  THR   A N   1 
ATOM   4925 C  CA  . THR   A 1 617 ? 1.749   -82.072  -28.467 1.00 54.67  ? 618  THR   A CA  1 
ATOM   4926 C  C   . THR   A 1 617 ? 1.561   -81.413  -29.841 1.00 58.61  ? 618  THR   A C   1 
ATOM   4927 O  O   . THR   A 1 617 ? 2.590   -81.146  -30.499 1.00 64.03  ? 618  THR   A O   1 
ATOM   4928 C  CB  . THR   A 1 617 ? 2.366   -83.469  -28.589 1.00 53.31  ? 618  THR   A CB  1 
ATOM   4929 O  OG1 . THR   A 1 617 ? 1.404   -84.351  -29.167 1.00 55.41  ? 618  THR   A OG1 1 
ATOM   4930 C  CG2 . THR   A 1 617 ? 2.823   -84.012  -27.253 1.00 53.67  ? 618  THR   A CG2 1 
ATOM   4931 N  N   . ALA   A 1 618 ? 0.314   -81.159  -30.260 1.00 58.21  ? 619  ALA   A N   1 
ATOM   4932 C  CA  . ALA   A 1 618 ? -0.029  -80.442  -31.512 1.00 56.48  ? 619  ALA   A CA  1 
ATOM   4933 C  C   . ALA   A 1 618 ? -1.368  -79.733  -31.335 1.00 53.97  ? 619  ALA   A C   1 
ATOM   4934 O  O   . ALA   A 1 618 ? -2.245  -80.254  -30.650 1.00 51.92  ? 619  ALA   A O   1 
ATOM   4935 C  CB  . ALA   A 1 618 ? -0.062  -81.412  -32.668 1.00 55.71  ? 619  ALA   A CB  1 
ATOM   4936 N  N   . PRO   A 1 619 ? -1.588  -78.544  -31.948 1.00 55.20  ? 620  PRO   A N   1 
ATOM   4937 C  CA  . PRO   A 1 619 ? -0.602  -77.889  -32.810 1.00 55.62  ? 620  PRO   A CA  1 
ATOM   4938 C  C   . PRO   A 1 619 ? 0.563   -77.207  -32.073 1.00 58.28  ? 620  PRO   A C   1 
ATOM   4939 O  O   . PRO   A 1 619 ? 1.491   -76.793  -32.740 1.00 64.45  ? 620  PRO   A O   1 
ATOM   4940 C  CB  . PRO   A 1 619 ? -1.443  -76.829  -33.538 1.00 53.33  ? 620  PRO   A CB  1 
ATOM   4941 C  CG  . PRO   A 1 619 ? -2.506  -76.464  -32.538 1.00 52.78  ? 620  PRO   A CG  1 
ATOM   4942 C  CD  . PRO   A 1 619 ? -2.842  -77.776  -31.862 1.00 55.06  ? 620  PRO   A CD  1 
ATOM   4943 N  N   . VAL   A 1 620 ? 0.485   -77.091  -30.744 1.00 58.19  ? 621  VAL   A N   1 
ATOM   4944 C  CA  . VAL   A 1 620 ? 1.629   -76.709  -29.861 1.00 57.20  ? 621  VAL   A CA  1 
ATOM   4945 C  C   . VAL   A 1 620 ? 1.692   -77.712  -28.710 1.00 57.95  ? 621  VAL   A C   1 
ATOM   4946 O  O   . VAL   A 1 620 ? 0.768   -78.540  -28.595 1.00 60.53  ? 621  VAL   A O   1 
ATOM   4947 C  CB  . VAL   A 1 620 ? 1.504   -75.270  -29.327 1.00 58.74  ? 621  VAL   A CB  1 
ATOM   4948 C  CG1 . VAL   A 1 620 ? 1.353   -74.268  -30.461 1.00 60.28  ? 621  VAL   A CG1 1 
ATOM   4949 C  CG2 . VAL   A 1 620 ? 0.369   -75.129  -28.323 1.00 58.90  ? 621  VAL   A CG2 1 
ATOM   4950 N  N   . CYS   A 1 621 ? 2.740   -77.624  -27.889 1.00 55.68  ? 622  CYS   A N   1 
ATOM   4951 C  CA  . CYS   A 1 621 ? 2.948   -78.485  -26.700 1.00 54.39  ? 622  CYS   A CA  1 
ATOM   4952 C  C   . CYS   A 1 621 ? 2.405   -77.770  -25.462 1.00 52.03  ? 622  CYS   A C   1 
ATOM   4953 O  O   . CYS   A 1 621 ? 2.625   -76.552  -25.333 1.00 52.07  ? 622  CYS   A O   1 
ATOM   4954 C  CB  . CYS   A 1 621 ? 4.418   -78.839  -26.502 1.00 56.77  ? 622  CYS   A CB  1 
ATOM   4955 S  SG  . CYS   A 1 621 ? 4.949   -80.253  -27.501 1.00 61.94  ? 622  CYS   A SG  1 
ATOM   4956 N  N   . SER   A 1 622 ? 1.695   -78.506  -24.608 1.00 48.41  ? 623  SER   A N   1 
ATOM   4957 C  CA  . SER   A 1 622 ? 1.429   -78.127  -23.201 1.00 47.23  ? 623  SER   A CA  1 
ATOM   4958 C  C   . SER   A 1 622 ? 2.566   -78.671  -22.336 1.00 48.58  ? 623  SER   A C   1 
ATOM   4959 O  O   . SER   A 1 622 ? 3.339   -79.529  -22.823 1.00 48.15  ? 623  SER   A O   1 
ATOM   4960 C  CB  . SER   A 1 622 ? 0.099   -78.657  -22.736 1.00 47.41  ? 623  SER   A CB  1 
ATOM   4961 O  OG  . SER   A 1 622 ? 0.095   -80.076  -22.695 1.00 45.00  ? 623  SER   A OG  1 
ATOM   4962 N  N   . ALA   A 1 623 ? 2.653   -78.205  -21.095 1.00 48.78  ? 624  ALA   A N   1 
ATOM   4963 C  CA  . ALA   A 1 623 ? 3.322   -78.942  -20.003 1.00 49.45  ? 624  ALA   A CA  1 
ATOM   4964 C  C   . ALA   A 1 623 ? 2.592   -80.278  -19.836 1.00 51.47  ? 624  ALA   A C   1 
ATOM   4965 O  O   . ALA   A 1 623 ? 1.363   -80.329  -20.084 1.00 51.26  ? 624  ALA   A O   1 
ATOM   4966 C  CB  . ALA   A 1 623 ? 3.304   -78.138  -18.726 1.00 48.63  ? 624  ALA   A CB  1 
ATOM   4967 N  N   . ILE   A 1 624 ? 3.331   -81.326  -19.476 1.00 50.51  ? 625  ILE   A N   1 
ATOM   4968 C  CA  . ILE   A 1 624 ? 2.751   -82.605  -18.989 1.00 48.92  ? 625  ILE   A CA  1 
ATOM   4969 C  C   . ILE   A 1 624 ? 1.982   -82.270  -17.709 1.00 48.51  ? 625  ILE   A C   1 
ATOM   4970 O  O   . ILE   A 1 624 ? 2.574   -81.641  -16.821 1.00 50.57  ? 625  ILE   A O   1 
ATOM   4971 C  CB  . ILE   A 1 624 ? 3.853   -83.658  -18.770 1.00 48.65  ? 625  ILE   A CB  1 
ATOM   4972 C  CG1 . ILE   A 1 624 ? 4.539   -84.009  -20.092 1.00 51.48  ? 625  ILE   A CG1 1 
ATOM   4973 C  CG2 . ILE   A 1 624 ? 3.297   -84.894  -18.077 1.00 47.99  ? 625  ILE   A CG2 1 
ATOM   4974 C  CD1 . ILE   A 1 624 ? 5.775   -84.859  -19.937 1.00 53.03  ? 625  ILE   A CD1 1 
ATOM   4975 N  N   . HIS   A 1 625 ? 0.704   -82.637  -17.646 1.00 46.89  ? 626  HIS   A N   1 
ATOM   4976 C  CA  . HIS   A 1 625 ? -0.179  -82.383  -16.481 1.00 49.00  ? 626  HIS   A CA  1 
ATOM   4977 C  C   . HIS   A 1 625 ? -0.093  -83.553  -15.498 1.00 49.90  ? 626  HIS   A C   1 
ATOM   4978 O  O   . HIS   A 1 625 ? 0.000   -84.707  -15.942 1.00 54.40  ? 626  HIS   A O   1 
ATOM   4979 C  CB  . HIS   A 1 625 ? -1.612  -82.097  -16.946 1.00 49.78  ? 626  HIS   A CB  1 
ATOM   4980 C  CG  . HIS   A 1 625 ? -1.760  -80.752  -17.569 1.00 48.54  ? 626  HIS   A CG  1 
ATOM   4981 N  ND1 . HIS   A 1 625 ? -1.083  -80.396  -18.717 1.00 48.73  ? 626  HIS   A ND1 1 
ATOM   4982 C  CD2 . HIS   A 1 625 ? -2.485  -79.674  -17.207 1.00 48.59  ? 626  HIS   A CD2 1 
ATOM   4983 C  CE1 . HIS   A 1 625 ? -1.390  -79.158  -19.039 1.00 49.58  ? 626  HIS   A CE1 1 
ATOM   4984 N  NE2 . HIS   A 1 625 ? -2.247  -78.695  -18.127 1.00 49.12  ? 626  HIS   A NE2 1 
ATOM   4985 N  N   . ASN   A 1 626 ? -0.097  -83.229  -14.206 1.00 48.79  ? 627  ASN   A N   1 
ATOM   4986 C  CA  . ASN   A 1 626 ? -0.144  -84.176  -13.061 1.00 47.78  ? 627  ASN   A CA  1 
ATOM   4987 C  C   . ASN   A 1 626 ? 1.046   -85.136  -13.094 1.00 47.26  ? 627  ASN   A C   1 
ATOM   4988 O  O   . ASN   A 1 626 ? 0.882   -86.323  -12.829 1.00 49.22  ? 627  ASN   A O   1 
ATOM   4989 C  CB  . ASN   A 1 626 ? -1.481  -84.914  -13.015 1.00 45.11  ? 627  ASN   A CB  1 
ATOM   4990 C  CG  . ASN   A 1 626 ? -1.735  -85.570  -11.675 1.00 44.65  ? 627  ASN   A CG  1 
ATOM   4991 O  OD1 . ASN   A 1 626 ? -1.397  -85.008  -10.638 1.00 46.14  ? 627  ASN   A OD1 1 
ATOM   4992 N  ND2 . ASN   A 1 626 ? -2.326  -86.754  -11.680 1.00 43.76  ? 627  ASN   A ND2 1 
ATOM   4993 N  N   . PRO   A 1 627 ? 2.292   -84.663  -13.332 1.00 47.72  ? 628  PRO   A N   1 
ATOM   4994 C  CA  . PRO   A 1 627 ? 3.461   -85.541  -13.261 1.00 48.43  ? 628  PRO   A CA  1 
ATOM   4995 C  C   . PRO   A 1 627 ? 3.625   -86.148  -11.860 1.00 48.92  ? 628  PRO   A C   1 
ATOM   4996 O  O   . PRO   A 1 627 ? 3.561   -85.405  -10.901 1.00 49.21  ? 628  PRO   A O   1 
ATOM   4997 C  CB  . PRO   A 1 627 ? 4.649   -84.630  -13.609 1.00 47.31  ? 628  PRO   A CB  1 
ATOM   4998 C  CG  . PRO   A 1 627 ? 4.141   -83.229  -13.343 1.00 48.02  ? 628  PRO   A CG  1 
ATOM   4999 C  CD  . PRO   A 1 627 ? 2.657   -83.272  -13.642 1.00 47.30  ? 628  PRO   A CD  1 
ATOM   5000 N  N   . THR   A 1 628 ? 3.797   -87.473  -11.790 1.00 51.71  ? 629  THR   A N   1 
ATOM   5001 C  CA  . THR   A 1 628 ? 4.019   -88.266  -10.546 1.00 55.09  ? 629  THR   A CA  1 
ATOM   5002 C  C   . THR   A 1 628 ? 2.733   -88.297  -9.704  1.00 54.15  ? 629  THR   A C   1 
ATOM   5003 O  O   . THR   A 1 628 ? 2.784   -88.770  -8.552  1.00 57.20  ? 629  THR   A O   1 
ATOM   5004 C  CB  . THR   A 1 628 ? 5.226   -87.729  -9.762  1.00 57.39  ? 629  THR   A CB  1 
ATOM   5005 O  OG1 . THR   A 1 628 ? 6.321   -87.574  -10.665 1.00 59.30  ? 629  THR   A OG1 1 
ATOM   5006 C  CG2 . THR   A 1 628 ? 5.676   -88.643  -8.644  1.00 62.94  ? 629  THR   A CG2 1 
ATOM   5007 N  N   . GLY   A 1 629 ? 1.606   -87.860  -10.268 1.00 51.37  ? 630  GLY   A N   1 
ATOM   5008 C  CA  . GLY   A 1 629 ? 0.339   -87.704  -9.532  1.00 50.71  ? 630  GLY   A CA  1 
ATOM   5009 C  C   . GLY   A 1 629 ? 0.452   -86.664  -8.431  1.00 48.80  ? 630  GLY   A C   1 
ATOM   5010 O  O   . GLY   A 1 629 ? -0.222  -86.824  -7.405  1.00 51.45  ? 630  GLY   A O   1 
ATOM   5011 N  N   . ARG   A 1 630 ? 1.265   -85.627  -8.637  1.00 47.47  ? 631  ARG   A N   1 
ATOM   5012 C  CA  . ARG   A 1 630 ? 1.564   -84.594  -7.611  1.00 48.06  ? 631  ARG   A CA  1 
ATOM   5013 C  C   . ARG   A 1 630 ? 0.270   -83.881  -7.192  1.00 50.64  ? 631  ARG   A C   1 
ATOM   5014 O  O   . ARG   A 1 630 ? 0.139   -83.568  -5.997  1.00 55.53  ? 631  ARG   A O   1 
ATOM   5015 C  CB  . ARG   A 1 630 ? 2.583   -83.588  -8.152  1.00 48.03  ? 631  ARG   A CB  1 
ATOM   5016 C  CG  . ARG   A 1 630 ? 2.044   -82.680  -9.251  1.00 47.90  ? 631  ARG   A CG  1 
ATOM   5017 C  CD  . ARG   A 1 630 ? 3.047   -81.612  -9.618  1.00 45.85  ? 631  ARG   A CD  1 
ATOM   5018 N  NE  . ARG   A 1 630 ? 2.719   -80.984  -10.885 1.00 46.44  ? 631  ARG   A NE  1 
ATOM   5019 C  CZ  . ARG   A 1 630 ? 3.567   -80.268  -11.617 1.00 47.05  ? 631  ARG   A CZ  1 
ATOM   5020 N  NH1 . ARG   A 1 630 ? 4.809   -80.075  -11.205 1.00 50.51  ? 631  ARG   A NH1 1 
ATOM   5021 N  NH2 . ARG   A 1 630 ? 3.172   -79.747  -12.764 1.00 45.75  ? 631  ARG   A NH2 1 
ATOM   5022 N  N   . SER   A 1 631 ? -0.638  -83.634  -8.143  1.00 49.45  ? 632  SER   A N   1 
ATOM   5023 C  CA  . SER   A 1 631 ? -1.892  -82.860  -7.958  1.00 50.11  ? 632  SER   A CA  1 
ATOM   5024 C  C   . SER   A 1 631 ? -3.084  -83.793  -7.715  1.00 48.94  ? 632  SER   A C   1 
ATOM   5025 O  O   . SER   A 1 631 ? -4.044  -83.362  -7.058  1.00 46.64  ? 632  SER   A O   1 
ATOM   5026 C  CB  . SER   A 1 631 ? -2.149  -81.967  -9.146  1.00 51.55  ? 632  SER   A CB  1 
ATOM   5027 O  OG  . SER   A 1 631 ? -1.149  -80.964  -9.257  1.00 52.54  ? 632  SER   A OG  1 
ATOM   5028 N  N   . TYR   A 1 632 ? -3.051  -85.009  -8.259  1.00 50.47  ? 633  TYR   A N   1 
ATOM   5029 C  CA  . TYR   A 1 632 ? -4.207  -85.940  -8.258  1.00 50.84  ? 633  TYR   A CA  1 
ATOM   5030 C  C   . TYR   A 1 632 ? -3.720  -87.383  -8.320  1.00 50.49  ? 633  TYR   A C   1 
ATOM   5031 O  O   . TYR   A 1 632 ? -2.909  -87.697  -9.216  1.00 49.41  ? 633  TYR   A O   1 
ATOM   5032 C  CB  . TYR   A 1 632 ? -5.118  -85.681  -9.457  1.00 50.80  ? 633  TYR   A CB  1 
ATOM   5033 C  CG  . TYR   A 1 632 ? -6.392  -86.484  -9.445  1.00 51.28  ? 633  TYR   A CG  1 
ATOM   5034 C  CD1 . TYR   A 1 632 ? -7.440  -86.140  -8.605  1.00 50.53  ? 633  TYR   A CD1 1 
ATOM   5035 C  CD2 . TYR   A 1 632 ? -6.556  -87.590  -10.266 1.00 50.43  ? 633  TYR   A CD2 1 
ATOM   5036 C  CE1 . TYR   A 1 632 ? -8.621  -86.864  -8.591  1.00 50.08  ? 633  TYR   A CE1 1 
ATOM   5037 C  CE2 . TYR   A 1 632 ? -7.728  -88.330  -10.259 1.00 48.78  ? 633  TYR   A CE2 1 
ATOM   5038 C  CZ  . TYR   A 1 632 ? -8.767  -87.963  -9.421  1.00 49.98  ? 633  TYR   A CZ  1 
ATOM   5039 O  OH  . TYR   A 1 632 ? -9.931  -88.676  -9.411  1.00 47.77  ? 633  TYR   A OH  1 
ATOM   5040 N  N   . THR   A 1 633 ? -4.214  -88.218  -7.403  1.00 50.18  ? 634  THR   A N   1 
ATOM   5041 C  CA  . THR   A 1 633 ? -4.016  -89.690  -7.402  1.00 51.44  ? 634  THR   A CA  1 
ATOM   5042 C  C   . THR   A 1 633 ? -5.318  -90.384  -7.010  1.00 50.81  ? 634  THR   A C   1 
ATOM   5043 O  O   . THR   A 1 633 ? -6.152  -89.750  -6.329  1.00 49.03  ? 634  THR   A O   1 
ATOM   5044 C  CB  . THR   A 1 633 ? -2.923  -90.131  -6.426  1.00 52.46  ? 634  THR   A CB  1 
ATOM   5045 O  OG1 . THR   A 1 633 ? -3.430  -89.917  -5.108  1.00 55.16  ? 634  THR   A OG1 1 
ATOM   5046 C  CG2 . THR   A 1 633 ? -1.619  -89.393  -6.623  1.00 53.91  ? 634  THR   A CG2 1 
ATOM   5047 N  N   . ILE   A 1 634 ? -5.451  -91.646  -7.417  1.00 51.50  ? 635  ILE   A N   1 
ATOM   5048 C  CA  . ILE   A 1 634 ? -6.582  -92.550  -7.065  1.00 50.01  ? 635  ILE   A CA  1 
ATOM   5049 C  C   . ILE   A 1 634 ? -6.008  -93.646  -6.164  1.00 50.14  ? 635  ILE   A C   1 
ATOM   5050 O  O   . ILE   A 1 634 ? -5.117  -94.378  -6.632  1.00 52.47  ? 635  ILE   A O   1 
ATOM   5051 C  CB  . ILE   A 1 634 ? -7.248  -93.101  -8.342  1.00 50.10  ? 635  ILE   A CB  1 
ATOM   5052 C  CG1 . ILE   A 1 634 ? -7.547  -91.986  -9.351  1.00 50.43  ? 635  ILE   A CG1 1 
ATOM   5053 C  CG2 . ILE   A 1 634 ? -8.498  -93.896  -8.000  1.00 51.08  ? 635  ILE   A CG2 1 
ATOM   5054 C  CD1 . ILE   A 1 634 ? -7.651  -92.454  -10.789 1.00 49.75  ? 635  ILE   A CD1 1 
ATOM   5055 N  N   . GLY   A 1 635 ? -6.474  -93.716  -4.914  1.00 49.55  ? 636  GLY   A N   1 
ATOM   5056 C  CA  . GLY   A 1 635 ? -5.924  -94.601  -3.873  1.00 49.73  ? 636  GLY   A CA  1 
ATOM   5057 C  C   . GLY   A 1 635 ? -6.230  -96.065  -4.140  1.00 52.72  ? 636  GLY   A C   1 
ATOM   5058 O  O   . GLY   A 1 635 ? -7.408  -96.390  -4.373  1.00 51.23  ? 636  GLY   A O   1 
ATOM   5059 N  N   . LEU   A 1 636 ? -5.202  -96.918  -4.087  1.00 55.12  ? 637  LEU   A N   1 
ATOM   5060 C  CA  . LEU   A 1 636 ? -5.338  -98.399  -4.039  1.00 61.13  ? 637  LEU   A CA  1 
ATOM   5061 C  C   . LEU   A 1 636 ? -5.579  -98.850  -2.590  1.00 62.53  ? 637  LEU   A C   1 
ATOM   5062 O  O   . LEU   A 1 636 ? -5.814  -98.053  -1.679  1.00 63.34  ? 637  LEU   A O   1 
ATOM   5063 C  CB  . LEU   A 1 636 ? -4.072  -99.040  -4.619  1.00 61.63  ? 637  LEU   A CB  1 
ATOM   5064 C  CG  . LEU   A 1 636 ? -3.932  -98.943  -6.136  1.00 60.54  ? 637  LEU   A CG  1 
ATOM   5065 C  CD1 . LEU   A 1 636 ? -2.508  -99.251  -6.571  1.00 60.94  ? 637  LEU   A CD1 1 
ATOM   5066 C  CD2 . LEU   A 1 636 ? -4.915  -99.873  -6.828  1.00 59.53  ? 637  LEU   A CD2 1 
ATOM   5067 O  OXT . LEU   A 1 636 ? -5.551  -100.044 -2.291  1.00 61.32  ? 637  LEU   A OXT 1 
ATOM   5068 N  N   . ASN   B 2 17  ? -42.942 -9.387   -18.058 1.00 138.07 ? 18   ASN   B N   1 
ATOM   5069 C  CA  . ASN   B 2 17  ? -42.983 -10.875  -18.157 1.00 140.20 ? 18   ASN   B CA  1 
ATOM   5070 C  C   . ASN   B 2 17  ? -44.341 -11.281  -18.748 1.00 143.11 ? 18   ASN   B C   1 
ATOM   5071 O  O   . ASN   B 2 17  ? -45.349 -11.185  -18.017 1.00 138.41 ? 18   ASN   B O   1 
ATOM   5072 C  CB  . ASN   B 2 17  ? -42.719 -11.514  -16.787 1.00 138.47 ? 18   ASN   B CB  1 
ATOM   5073 C  CG  . ASN   B 2 17  ? -42.327 -12.977  -16.845 1.00 134.66 ? 18   ASN   B CG  1 
ATOM   5074 O  OD1 . ASN   B 2 17  ? -41.158 -13.301  -17.044 1.00 129.79 ? 18   ASN   B OD1 1 
ATOM   5075 N  ND2 . ASN   B 2 17  ? -43.282 -13.868  -16.628 1.00 131.63 ? 18   ASN   B ND2 1 
ATOM   5076 N  N   . LEU   B 2 18  ? -44.373 -11.691  -20.024 1.00 150.57 ? 19   LEU   B N   1 
ATOM   5077 C  CA  . LEU   B 2 18  ? -45.606 -12.156  -20.727 1.00 156.23 ? 19   LEU   B CA  1 
ATOM   5078 C  C   . LEU   B 2 18  ? -45.370 -13.545  -21.325 1.00 160.09 ? 19   LEU   B C   1 
ATOM   5079 O  O   . LEU   B 2 18  ? -45.117 -13.673  -22.518 1.00 168.40 ? 19   LEU   B O   1 
ATOM   5080 C  CB  . LEU   B 2 18  ? -46.033 -11.126  -21.787 1.00 155.72 ? 19   LEU   B CB  1 
ATOM   5081 C  CG  . LEU   B 2 18  ? -44.993 -10.698  -22.830 1.00 153.65 ? 19   LEU   B CG  1 
ATOM   5082 C  CD1 . LEU   B 2 18  ? -45.300 -11.289  -24.201 1.00 151.12 ? 19   LEU   B CD1 1 
ATOM   5083 C  CD2 . LEU   B 2 18  ? -44.930 -9.180   -22.938 1.00 152.34 ? 19   LEU   B CD2 1 
ATOM   5084 N  N   . PRO   B 2 19  ? -45.441 -14.632  -20.517 1.00 156.98 ? 20   PRO   B N   1 
ATOM   5085 C  CA  . PRO   B 2 19  ? -45.278 -15.995  -21.028 1.00 152.45 ? 20   PRO   B CA  1 
ATOM   5086 C  C   . PRO   B 2 19  ? -46.585 -16.546  -21.600 1.00 143.29 ? 20   PRO   B C   1 
ATOM   5087 O  O   . PRO   B 2 19  ? -47.455 -16.984  -20.850 1.00 137.96 ? 20   PRO   B O   1 
ATOM   5088 C  CB  . PRO   B 2 19  ? -44.817 -16.766  -19.780 1.00 154.49 ? 20   PRO   B CB  1 
ATOM   5089 C  CG  . PRO   B 2 19  ? -45.489 -16.049  -18.621 1.00 156.67 ? 20   PRO   B CG  1 
ATOM   5090 C  CD  . PRO   B 2 19  ? -45.668 -14.609  -19.063 1.00 157.88 ? 20   PRO   B CD  1 
ATOM   5091 N  N   . PRO   B 2 20  ? -46.766 -16.552  -22.943 1.00 136.25 ? 21   PRO   B N   1 
ATOM   5092 C  CA  . PRO   B 2 20  ? -48.075 -16.808  -23.548 1.00 135.37 ? 21   PRO   B CA  1 
ATOM   5093 C  C   . PRO   B 2 20  ? -48.394 -18.294  -23.780 1.00 135.26 ? 21   PRO   B C   1 
ATOM   5094 O  O   . PRO   B 2 20  ? -48.328 -18.736  -24.914 1.00 136.15 ? 21   PRO   B O   1 
ATOM   5095 C  CB  . PRO   B 2 20  ? -47.929 -16.063  -24.882 1.00 135.98 ? 21   PRO   B CB  1 
ATOM   5096 C  CG  . PRO   B 2 20  ? -46.484 -16.303  -25.269 1.00 133.88 ? 21   PRO   B CG  1 
ATOM   5097 C  CD  . PRO   B 2 20  ? -45.726 -16.312  -23.957 1.00 133.29 ? 21   PRO   B CD  1 
ATOM   5098 N  N   . ASN   B 2 21  ? -48.750 -19.014  -22.712 1.00 137.03 ? 22   ASN   B N   1 
ATOM   5099 C  CA  . ASN   B 2 21  ? -49.076 -20.468  -22.738 1.00 140.91 ? 22   ASN   B CA  1 
ATOM   5100 C  C   . ASN   B 2 21  ? -47.838 -21.242  -23.218 1.00 143.37 ? 22   ASN   B C   1 
ATOM   5101 O  O   . ASN   B 2 21  ? -47.951 -22.011  -24.199 1.00 142.75 ? 22   ASN   B O   1 
ATOM   5102 C  CB  . ASN   B 2 21  ? -50.325 -20.744  -23.583 1.00 140.88 ? 22   ASN   B CB  1 
ATOM   5103 C  CG  . ASN   B 2 21  ? -50.902 -22.131  -23.378 1.00 141.74 ? 22   ASN   B CG  1 
ATOM   5104 O  OD1 . ASN   B 2 21  ? -50.237 -23.023  -22.853 1.00 140.64 ? 22   ASN   B OD1 1 
ATOM   5105 N  ND2 . ASN   B 2 21  ? -52.142 -22.326  -23.795 1.00 139.30 ? 22   ASN   B ND2 1 
ATOM   5106 N  N   . ALA   B 2 22  ? -46.702 -21.030  -22.545 1.00 144.06 ? 23   ALA   B N   1 
ATOM   5107 C  CA  . ALA   B 2 22  ? -45.401 -21.698  -22.793 1.00 139.50 ? 23   ALA   B CA  1 
ATOM   5108 C  C   . ALA   B 2 22  ? -44.801 -22.129  -21.457 1.00 137.08 ? 23   ALA   B C   1 
ATOM   5109 O  O   . ALA   B 2 22  ? -45.256 -21.678  -20.407 1.00 139.32 ? 23   ALA   B O   1 
ATOM   5110 C  CB  . ALA   B 2 22  ? -44.485 -20.758  -23.540 1.00 137.80 ? 23   ALA   B CB  1 
ATOM   5111 N  N   . PRO   B 2 23  ? -43.780 -23.020  -21.441 1.00 131.27 ? 24   PRO   B N   1 
ATOM   5112 C  CA  . PRO   B 2 23  ? -43.120 -23.412  -20.193 1.00 126.77 ? 24   PRO   B CA  1 
ATOM   5113 C  C   . PRO   B 2 23  ? -42.576 -22.199  -19.421 1.00 122.02 ? 24   PRO   B C   1 
ATOM   5114 O  O   . PRO   B 2 23  ? -42.018 -21.312  -20.041 1.00 114.82 ? 24   PRO   B O   1 
ATOM   5115 C  CB  . PRO   B 2 23  ? -41.974 -24.328  -20.652 1.00 126.71 ? 24   PRO   B CB  1 
ATOM   5116 C  CG  . PRO   B 2 23  ? -42.444 -24.861  -21.987 1.00 128.08 ? 24   PRO   B CG  1 
ATOM   5117 C  CD  . PRO   B 2 23  ? -43.223 -23.721  -22.609 1.00 130.04 ? 24   PRO   B CD  1 
ATOM   5118 N  N   . ALA   B 2 24  ? -42.762 -22.189  -18.098 1.00 120.34 ? 25   ALA   B N   1 
ATOM   5119 C  CA  . ALA   B 2 24  ? -42.341 -21.099  -17.183 1.00 119.83 ? 25   ALA   B CA  1 
ATOM   5120 C  C   . ALA   B 2 24  ? -40.816 -20.933  -17.227 1.00 117.43 ? 25   ALA   B C   1 
ATOM   5121 O  O   . ALA   B 2 24  ? -40.342 -19.785  -17.102 1.00 116.52 ? 25   ALA   B O   1 
ATOM   5122 C  CB  . ALA   B 2 24  ? -42.822 -21.390  -15.782 1.00 119.34 ? 25   ALA   B CB  1 
ATOM   5123 N  N   . CYS   B 2 25  ? -40.086 -22.040  -17.408 1.00 116.45 ? 26   CYS   B N   1 
ATOM   5124 C  CA  . CYS   B 2 25  ? -38.603 -22.121  -17.328 1.00 110.31 ? 26   CYS   B CA  1 
ATOM   5125 C  C   . CYS   B 2 25  ? -38.053 -22.920  -18.520 1.00 102.85 ? 26   CYS   B C   1 
ATOM   5126 O  O   . CYS   B 2 25  ? -38.613 -23.996  -18.824 1.00 97.80  ? 26   CYS   B O   1 
ATOM   5127 C  CB  . CYS   B 2 25  ? -38.197 -22.745  -15.998 1.00 112.06 ? 26   CYS   B CB  1 
ATOM   5128 S  SG  . CYS   B 2 25  ? -36.494 -23.358  -15.971 1.00 118.87 ? 26   CYS   B SG  1 
ATOM   5129 N  N   . MET   B 2 26  ? -36.998 -22.402  -19.163 1.00 96.12  ? 27   MET   B N   1 
ATOM   5130 C  CA  . MET   B 2 26  ? -36.343 -22.986  -20.368 1.00 92.20  ? 27   MET   B CA  1 
ATOM   5131 C  C   . MET   B 2 26  ? -35.097 -23.777  -19.942 1.00 88.61  ? 27   MET   B C   1 
ATOM   5132 O  O   . MET   B 2 26  ? -34.290 -23.224  -19.168 1.00 87.72  ? 27   MET   B O   1 
ATOM   5133 C  CB  . MET   B 2 26  ? -35.931 -21.886  -21.355 1.00 90.57  ? 27   MET   B CB  1 
ATOM   5134 C  CG  . MET   B 2 26  ? -35.133 -22.401  -22.544 1.00 90.60  ? 27   MET   B CG  1 
ATOM   5135 S  SD  . MET   B 2 26  ? -34.984 -21.207  -23.901 1.00 91.56  ? 27   MET   B SD  1 
ATOM   5136 C  CE  . MET   B 2 26  ? -33.675 -20.152  -23.292 1.00 90.20  ? 27   MET   B CE  1 
ATOM   5137 N  N   . GLU   B 2 27  ? -34.933 -24.996  -20.474 1.00 84.40  ? 28   GLU   B N   1 
ATOM   5138 C  CA  . GLU   B 2 27  ? -33.857 -25.962  -20.108 1.00 81.63  ? 28   GLU   B CA  1 
ATOM   5139 C  C   . GLU   B 2 27  ? -32.469 -25.351  -20.369 1.00 80.41  ? 28   GLU   B C   1 
ATOM   5140 O  O   . GLU   B 2 27  ? -32.321 -24.624  -21.370 1.00 81.63  ? 28   GLU   B O   1 
ATOM   5141 C  CB  . GLU   B 2 27  ? -34.019 -27.269  -20.886 1.00 78.81  ? 28   GLU   B CB  1 
ATOM   5142 C  CG  . GLU   B 2 27  ? -35.211 -28.106  -20.453 1.00 79.51  ? 28   GLU   B CG  1 
ATOM   5143 C  CD  . GLU   B 2 27  ? -36.501 -27.859  -21.219 1.00 81.02  ? 28   GLU   B CD  1 
ATOM   5144 O  OE1 . GLU   B 2 27  ? -36.711 -26.717  -21.669 1.00 87.60  ? 28   GLU   B OE1 1 
ATOM   5145 O  OE2 . GLU   B 2 27  ? -37.291 -28.812  -21.363 1.00 78.23  ? 28   GLU   B OE2 1 
ATOM   5146 N  N   . ARG   B 2 28  ? -31.494 -25.667  -19.506 1.00 75.55  ? 29   ARG   B N   1 
ATOM   5147 C  CA  . ARG   B 2 28  ? -30.146 -25.033  -19.438 1.00 74.86  ? 29   ARG   B CA  1 
ATOM   5148 C  C   . ARG   B 2 28  ? -29.420 -25.160  -20.786 1.00 74.09  ? 29   ARG   B C   1 
ATOM   5149 O  O   . ARG   B 2 28  ? -28.804 -24.163  -21.216 1.00 72.57  ? 29   ARG   B O   1 
ATOM   5150 C  CB  . ARG   B 2 28  ? -29.327 -25.673  -18.310 1.00 76.82  ? 29   ARG   B CB  1 
ATOM   5151 C  CG  . ARG   B 2 28  ? -27.884 -25.195  -18.199 1.00 78.71  ? 29   ARG   B CG  1 
ATOM   5152 C  CD  . ARG   B 2 28  ? -27.730 -23.917  -17.397 1.00 84.96  ? 29   ARG   B CD  1 
ATOM   5153 N  NE  . ARG   B 2 28  ? -26.331 -23.550  -17.211 1.00 89.76  ? 29   ARG   B NE  1 
ATOM   5154 C  CZ  . ARG   B 2 28  ? -25.905 -22.422  -16.641 1.00 94.57  ? 29   ARG   B CZ  1 
ATOM   5155 N  NH1 . ARG   B 2 28  ? -26.771 -21.526  -16.191 1.00 95.16  ? 29   ARG   B NH1 1 
ATOM   5156 N  NH2 . ARG   B 2 28  ? -24.608 -22.192  -16.525 1.00 94.26  ? 29   ARG   B NH2 1 
ATOM   5157 N  N   . GLN   B 2 29  ? -29.480 -26.334  -21.422 1.00 73.01  ? 30   GLN   B N   1 
ATOM   5158 C  CA  . GLN   B 2 29  ? -28.597 -26.696  -22.563 1.00 73.03  ? 30   GLN   B CA  1 
ATOM   5159 C  C   . GLN   B 2 29  ? -29.256 -26.285  -23.885 1.00 75.78  ? 30   GLN   B C   1 
ATOM   5160 O  O   . GLN   B 2 29  ? -30.148 -27.022  -24.369 1.00 73.83  ? 30   GLN   B O   1 
ATOM   5161 C  CB  . GLN   B 2 29  ? -28.251 -28.186  -22.525 1.00 71.95  ? 30   GLN   B CB  1 
ATOM   5162 C  CG  . GLN   B 2 29  ? -27.335 -28.561  -21.366 1.00 70.25  ? 30   GLN   B CG  1 
ATOM   5163 C  CD  . GLN   B 2 29  ? -28.071 -28.783  -20.064 1.00 65.85  ? 30   GLN   B CD  1 
ATOM   5164 O  OE1 . GLN   B 2 29  ? -29.184 -29.304  -20.031 1.00 68.36  ? 30   GLN   B OE1 1 
ATOM   5165 N  NE2 . GLN   B 2 29  ? -27.441 -28.404  -18.967 1.00 61.44  ? 30   GLN   B NE2 1 
ATOM   5166 N  N   . LEU   B 2 30  ? -28.809 -25.151  -24.441 1.00 75.58  ? 31   LEU   B N   1 
ATOM   5167 C  CA  . LEU   B 2 30  ? -29.240 -24.619  -25.760 1.00 77.70  ? 31   LEU   B CA  1 
ATOM   5168 C  C   . LEU   B 2 30  ? -28.436 -25.327  -26.854 1.00 76.68  ? 31   LEU   B C   1 
ATOM   5169 O  O   . LEU   B 2 30  ? -27.199 -25.183  -26.849 1.00 74.51  ? 31   LEU   B O   1 
ATOM   5170 C  CB  . LEU   B 2 30  ? -29.010 -23.103  -25.809 1.00 79.71  ? 31   LEU   B CB  1 
ATOM   5171 C  CG  . LEU   B 2 30  ? -29.601 -22.295  -24.652 1.00 78.76  ? 31   LEU   B CG  1 
ATOM   5172 C  CD1 . LEU   B 2 30  ? -29.226 -20.824  -24.772 1.00 78.82  ? 31   LEU   B CD1 1 
ATOM   5173 C  CD2 . LEU   B 2 30  ? -31.112 -22.457  -24.591 1.00 76.87  ? 31   LEU   B CD2 1 
ATOM   5174 N  N   . GLU   B 2 31  ? -29.117 -26.055  -27.745 1.00 77.99  ? 32   GLU   B N   1 
ATOM   5175 C  CA  . GLU   B 2 31  ? -28.494 -26.816  -28.861 1.00 82.25  ? 32   GLU   B CA  1 
ATOM   5176 C  C   . GLU   B 2 31  ? -28.607 -26.038  -30.178 1.00 83.30  ? 32   GLU   B C   1 
ATOM   5177 O  O   . GLU   B 2 31  ? -27.649 -26.104  -30.976 1.00 85.67  ? 32   GLU   B O   1 
ATOM   5178 C  CB  . GLU   B 2 31  ? -29.132 -28.201  -28.994 1.00 86.48  ? 32   GLU   B CB  1 
ATOM   5179 C  CG  . GLU   B 2 31  ? -28.293 -29.306  -28.375 1.00 87.59  ? 32   GLU   B CG  1 
ATOM   5180 C  CD  . GLU   B 2 31  ? -26.935 -29.547  -29.013 1.00 88.50  ? 32   GLU   B CD  1 
ATOM   5181 O  OE1 . GLU   B 2 31  ? -26.723 -29.120  -30.167 1.00 85.82  ? 32   GLU   B OE1 1 
ATOM   5182 O  OE2 . GLU   B 2 31  ? -26.082 -30.156  -28.344 1.00 95.03  ? 32   GLU   B OE2 1 
ATOM   5183 N  N   . ALA   B 2 32  ? -29.723 -25.335  -30.403 1.00 84.16  ? 33   ALA   B N   1 
ATOM   5184 C  CA  . ALA   B 2 32  ? -30.107 -24.785  -31.725 1.00 82.74  ? 33   ALA   B CA  1 
ATOM   5185 C  C   . ALA   B 2 32  ? -30.378 -23.280  -31.635 1.00 82.08  ? 33   ALA   B C   1 
ATOM   5186 O  O   . ALA   B 2 32  ? -31.078 -22.857  -30.695 1.00 79.81  ? 33   ALA   B O   1 
ATOM   5187 C  CB  . ALA   B 2 32  ? -31.309 -25.530  -32.244 1.00 81.24  ? 33   ALA   B CB  1 
ATOM   5188 N  N   . ALA   B 2 33  ? -29.846 -22.523  -32.602 1.00 84.07  ? 34   ALA   B N   1 
ATOM   5189 C  CA  . ALA   B 2 33  ? -30.064 -21.071  -32.806 1.00 87.33  ? 34   ALA   B CA  1 
ATOM   5190 C  C   . ALA   B 2 33  ? -30.107 -20.784  -34.312 1.00 89.72  ? 34   ALA   B C   1 
ATOM   5191 O  O   . ALA   B 2 33  ? -29.047 -20.898  -34.959 1.00 90.18  ? 34   ALA   B O   1 
ATOM   5192 C  CB  . ALA   B 2 33  ? -28.977 -20.282  -32.124 1.00 84.71  ? 34   ALA   B CB  1 
ATOM   5193 N  N   . ARG   B 2 34  ? -31.290 -20.445  -34.838 1.00 92.13  ? 35   ARG   B N   1 
ATOM   5194 C  CA  . ARG   B 2 34  ? -31.566 -20.283  -36.293 1.00 95.17  ? 35   ARG   B CA  1 
ATOM   5195 C  C   . ARG   B 2 34  ? -32.462 -19.056  -36.515 1.00 93.88  ? 35   ARG   B C   1 
ATOM   5196 O  O   . ARG   B 2 34  ? -33.594 -19.051  -35.988 1.00 92.68  ? 35   ARG   B O   1 
ATOM   5197 C  CB  . ARG   B 2 34  ? -32.253 -21.539  -36.847 1.00 96.27  ? 35   ARG   B CB  1 
ATOM   5198 C  CG  . ARG   B 2 34  ? -31.589 -22.864  -36.491 1.00 98.68  ? 35   ARG   B CG  1 
ATOM   5199 C  CD  . ARG   B 2 34  ? -30.247 -23.091  -37.167 1.00 99.54  ? 35   ARG   B CD  1 
ATOM   5200 N  NE  . ARG   B 2 34  ? -30.158 -24.405  -37.802 1.00 102.58 ? 35   ARG   B NE  1 
ATOM   5201 C  CZ  . ARG   B 2 34  ? -29.867 -25.554  -37.189 1.00 105.85 ? 35   ARG   B CZ  1 
ATOM   5202 N  NH1 . ARG   B 2 34  ? -29.624 -25.594  -35.889 1.00 108.39 ? 35   ARG   B NH1 1 
ATOM   5203 N  NH2 . ARG   B 2 34  ? -29.824 -26.675  -37.889 1.00 108.35 ? 35   ARG   B NH2 1 
ATOM   5204 N  N   . TYR   B 2 35  ? -31.986 -18.061  -37.273 1.00 91.89  ? 36   TYR   B N   1 
ATOM   5205 C  CA  . TYR   B 2 35  ? -32.785 -16.884  -37.715 1.00 90.90  ? 36   TYR   B CA  1 
ATOM   5206 C  C   . TYR   B 2 35  ? -33.642 -17.270  -38.928 1.00 90.87  ? 36   TYR   B C   1 
ATOM   5207 O  O   . TYR   B 2 35  ? -33.126 -17.950  -39.840 1.00 84.81  ? 36   TYR   B O   1 
ATOM   5208 C  CB  . TYR   B 2 35  ? -31.901 -15.688  -38.087 1.00 88.98  ? 36   TYR   B CB  1 
ATOM   5209 C  CG  . TYR   B 2 35  ? -31.418 -14.838  -36.936 1.00 90.23  ? 36   TYR   B CG  1 
ATOM   5210 C  CD1 . TYR   B 2 35  ? -32.298 -14.300  -36.007 1.00 88.73  ? 36   TYR   B CD1 1 
ATOM   5211 C  CD2 . TYR   B 2 35  ? -30.073 -14.535  -36.795 1.00 91.29  ? 36   TYR   B CD2 1 
ATOM   5212 C  CE1 . TYR   B 2 35  ? -31.850 -13.510  -34.959 1.00 89.40  ? 36   TYR   B CE1 1 
ATOM   5213 C  CE2 . TYR   B 2 35  ? -29.608 -13.743  -35.757 1.00 90.89  ? 36   TYR   B CE2 1 
ATOM   5214 C  CZ  . TYR   B 2 35  ? -30.500 -13.228  -34.834 1.00 90.78  ? 36   TYR   B CZ  1 
ATOM   5215 O  OH  . TYR   B 2 35  ? -30.037 -12.448  -33.813 1.00 90.69  ? 36   TYR   B OH  1 
ATOM   5216 N  N   . ARG   B 2 36  ? -34.908 -16.833  -38.927 1.00 93.03  ? 37   ARG   B N   1 
ATOM   5217 C  CA  . ARG   B 2 36  ? -35.865 -16.934  -40.065 1.00 93.50  ? 37   ARG   B CA  1 
ATOM   5218 C  C   . ARG   B 2 36  ? -35.572 -15.791  -41.048 1.00 94.35  ? 37   ARG   B C   1 
ATOM   5219 O  O   . ARG   B 2 36  ? -34.810 -14.878  -40.671 1.00 91.82  ? 37   ARG   B O   1 
ATOM   5220 C  CB  . ARG   B 2 36  ? -37.296 -16.884  -39.520 1.00 92.94  ? 37   ARG   B CB  1 
ATOM   5221 C  CG  . ARG   B 2 36  ? -38.395 -17.047  -40.559 1.00 93.83  ? 37   ARG   B CG  1 
ATOM   5222 C  CD  . ARG   B 2 36  ? -39.762 -17.201  -39.915 1.00 95.27  ? 37   ARG   B CD  1 
ATOM   5223 N  NE  . ARG   B 2 36  ? -40.178 -16.004  -39.191 1.00 95.02  ? 37   ARG   B NE  1 
ATOM   5224 C  CZ  . ARG   B 2 36  ? -41.340 -15.860  -38.555 1.00 95.19  ? 37   ARG   B CZ  1 
ATOM   5225 N  NH1 . ARG   B 2 36  ? -42.221 -16.847  -38.542 1.00 94.47  ? 37   ARG   B NH1 1 
ATOM   5226 N  NH2 . ARG   B 2 36  ? -41.615 -14.726  -37.933 1.00 94.37  ? 37   ARG   B NH2 1 
ATOM   5227 N  N   . SER   B 2 37  ? -36.134 -15.847  -42.263 1.00 97.62  ? 38   SER   B N   1 
ATOM   5228 C  CA  . SER   B 2 37  ? -35.973 -14.826  -43.336 1.00 97.42  ? 38   SER   B CA  1 
ATOM   5229 C  C   . SER   B 2 37  ? -36.222 -13.414  -42.782 1.00 96.00  ? 38   SER   B C   1 
ATOM   5230 O  O   . SER   B 2 37  ? -35.437 -12.507  -43.119 1.00 96.47  ? 38   SER   B O   1 
ATOM   5231 C  CB  . SER   B 2 37  ? -36.876 -15.117  -44.510 1.00 97.46  ? 38   SER   B CB  1 
ATOM   5232 O  OG  . SER   B 2 37  ? -38.240 -14.968  -44.147 1.00 98.89  ? 38   SER   B OG  1 
ATOM   5233 N  N   . ASP   B 2 38  ? -37.257 -13.247  -41.950 1.00 93.84  ? 39   ASP   B N   1 
ATOM   5234 C  CA  . ASP   B 2 38  ? -37.738 -11.930  -41.447 1.00 95.93  ? 39   ASP   B CA  1 
ATOM   5235 C  C   . ASP   B 2 38  ? -36.827 -11.394  -40.329 1.00 97.52  ? 39   ASP   B C   1 
ATOM   5236 O  O   . ASP   B 2 38  ? -36.845 -10.165  -40.117 1.00 99.32  ? 39   ASP   B O   1 
ATOM   5237 C  CB  . ASP   B 2 38  ? -39.191 -12.015  -40.972 1.00 95.60  ? 39   ASP   B CB  1 
ATOM   5238 C  CG  . ASP   B 2 38  ? -39.356 -12.643  -39.600 1.00 95.44  ? 39   ASP   B CG  1 
ATOM   5239 O  OD1 . ASP   B 2 38  ? -38.745 -13.703  -39.366 1.00 102.38 ? 39   ASP   B OD1 1 
ATOM   5240 O  OD2 . ASP   B 2 38  ? -40.088 -12.066  -38.775 1.00 92.76  ? 39   ASP   B OD2 1 
ATOM   5241 N  N   . GLY   B 2 39  ? -36.099 -12.266  -39.619 1.00 98.29  ? 40   GLY   B N   1 
ATOM   5242 C  CA  . GLY   B 2 39  ? -35.107 -11.879  -38.590 1.00 95.20  ? 40   GLY   B CA  1 
ATOM   5243 C  C   . GLY   B 2 39  ? -35.505 -12.282  -37.175 1.00 92.48  ? 40   GLY   B C   1 
ATOM   5244 O  O   . GLY   B 2 39  ? -34.792 -11.871  -36.230 1.00 86.53  ? 40   GLY   B O   1 
ATOM   5245 N  N   . ALA   B 2 40  ? -36.599 -13.041  -37.022 1.00 89.06  ? 41   ALA   B N   1 
ATOM   5246 C  CA  . ALA   B 2 40  ? -37.040 -13.669  -35.753 1.00 89.87  ? 41   ALA   B CA  1 
ATOM   5247 C  C   . ALA   B 2 40  ? -36.165 -14.898  -35.473 1.00 91.52  ? 41   ALA   B C   1 
ATOM   5248 O  O   . ALA   B 2 40  ? -35.659 -15.489  -36.449 1.00 94.67  ? 41   ALA   B O   1 
ATOM   5249 C  CB  . ALA   B 2 40  ? -38.503 -14.034  -35.837 1.00 90.09  ? 41   ALA   B CB  1 
ATOM   5250 N  N   . LEU   B 2 41  ? -36.005 -15.274  -34.197 1.00 90.54  ? 42   LEU   B N   1 
ATOM   5251 C  CA  . LEU   B 2 41  ? -35.010 -16.285  -33.739 1.00 86.76  ? 42   LEU   B CA  1 
ATOM   5252 C  C   . LEU   B 2 41  ? -35.706 -17.541  -33.201 1.00 84.29  ? 42   LEU   B C   1 
ATOM   5253 O  O   . LEU   B 2 41  ? -36.431 -17.437  -32.190 1.00 81.53  ? 42   LEU   B O   1 
ATOM   5254 C  CB  . LEU   B 2 41  ? -34.121 -15.652  -32.665 1.00 88.42  ? 42   LEU   B CB  1 
ATOM   5255 C  CG  . LEU   B 2 41  ? -32.983 -16.528  -32.137 1.00 90.58  ? 42   LEU   B CG  1 
ATOM   5256 C  CD1 . LEU   B 2 41  ? -32.277 -17.269  -33.264 1.00 90.19  ? 42   LEU   B CD1 1 
ATOM   5257 C  CD2 . LEU   B 2 41  ? -31.985 -15.690  -31.351 1.00 92.34  ? 42   LEU   B CD2 1 
ATOM   5258 N  N   . LEU   B 2 42  ? -35.460 -18.685  -33.850 1.00 83.58  ? 43   LEU   B N   1 
ATOM   5259 C  CA  . LEU   B 2 42  ? -35.849 -20.043  -33.380 1.00 80.97  ? 43   LEU   B CA  1 
ATOM   5260 C  C   . LEU   B 2 42  ? -34.776 -20.557  -32.414 1.00 81.15  ? 43   LEU   B C   1 
ATOM   5261 O  O   . LEU   B 2 42  ? -33.592 -20.572  -32.815 1.00 79.64  ? 43   LEU   B O   1 
ATOM   5262 C  CB  . LEU   B 2 42  ? -35.979 -20.974  -34.591 1.00 78.32  ? 43   LEU   B CB  1 
ATOM   5263 C  CG  . LEU   B 2 42  ? -36.386 -22.417  -34.297 1.00 76.11  ? 43   LEU   B CG  1 
ATOM   5264 C  CD1 . LEU   B 2 42  ? -37.715 -22.480  -33.556 1.00 76.43  ? 43   LEU   B CD1 1 
ATOM   5265 C  CD2 . LEU   B 2 42  ? -36.456 -23.224  -35.584 1.00 74.08  ? 43   LEU   B CD2 1 
ATOM   5266 N  N   . LEU   B 2 43  ? -35.175 -20.949  -31.199 1.00 81.96  ? 44   LEU   B N   1 
ATOM   5267 C  CA  . LEU   B 2 43  ? -34.299 -21.621  -30.201 1.00 83.39  ? 44   LEU   B CA  1 
ATOM   5268 C  C   . LEU   B 2 43  ? -34.804 -23.047  -29.958 1.00 84.49  ? 44   LEU   B C   1 
ATOM   5269 O  O   . LEU   B 2 43  ? -36.026 -23.223  -29.773 1.00 80.30  ? 44   LEU   B O   1 
ATOM   5270 C  CB  . LEU   B 2 43  ? -34.282 -20.827  -28.889 1.00 86.44  ? 44   LEU   B CB  1 
ATOM   5271 C  CG  . LEU   B 2 43  ? -33.404 -19.576  -28.860 1.00 90.49  ? 44   LEU   B CG  1 
ATOM   5272 C  CD1 . LEU   B 2 43  ? -33.372 -18.980  -27.461 1.00 92.23  ? 44   LEU   B CD1 1 
ATOM   5273 C  CD2 . LEU   B 2 43  ? -31.989 -19.869  -29.334 1.00 91.72  ? 44   LEU   B CD2 1 
ATOM   5274 N  N   . GLY   B 2 44  ? -33.884 -24.017  -29.988 1.00 85.47  ? 45   GLY   B N   1 
ATOM   5275 C  CA  . GLY   B 2 44  ? -34.072 -25.382  -29.461 1.00 81.95  ? 45   GLY   B CA  1 
ATOM   5276 C  C   . GLY   B 2 44  ? -33.240 -25.566  -28.207 1.00 80.89  ? 45   GLY   B C   1 
ATOM   5277 O  O   . GLY   B 2 44  ? -32.112 -25.034  -28.175 1.00 81.13  ? 45   GLY   B O   1 
ATOM   5278 N  N   . ALA   B 2 45  ? -33.778 -26.254  -27.197 1.00 82.26  ? 46   ALA   B N   1 
ATOM   5279 C  CA  . ALA   B 2 45  ? -33.117 -26.475  -25.887 1.00 83.66  ? 46   ALA   B CA  1 
ATOM   5280 C  C   . ALA   B 2 45  ? -33.546 -27.825  -25.303 1.00 80.81  ? 46   ALA   B C   1 
ATOM   5281 O  O   . ALA   B 2 45  ? -34.712 -28.205  -25.497 1.00 76.72  ? 46   ALA   B O   1 
ATOM   5282 C  CB  . ALA   B 2 45  ? -33.450 -25.344  -24.945 1.00 83.68  ? 46   ALA   B CB  1 
ATOM   5283 N  N   . SER   B 2 46  ? -32.629 -28.511  -24.613 1.00 80.49  ? 47   SER   B N   1 
ATOM   5284 C  CA  . SER   B 2 46  ? -32.893 -29.786  -23.894 1.00 79.12  ? 47   SER   B CA  1 
ATOM   5285 C  C   . SER   B 2 46  ? -32.294 -29.735  -22.485 1.00 75.50  ? 47   SER   B C   1 
ATOM   5286 O  O   . SER   B 2 46  ? -31.367 -28.925  -22.258 1.00 71.20  ? 47   SER   B O   1 
ATOM   5287 C  CB  . SER   B 2 46  ? -32.390 -30.978  -24.675 1.00 80.37  ? 47   SER   B CB  1 
ATOM   5288 O  OG  . SER   B 2 46  ? -31.165 -30.696  -25.337 1.00 79.96  ? 47   SER   B OG  1 
ATOM   5289 N  N   . SER   B 2 47  ? -32.853 -30.536  -21.570 1.00 74.29  ? 48   SER   B N   1 
ATOM   5290 C  CA  . SER   B 2 47  ? -32.267 -30.868  -20.243 1.00 75.00  ? 48   SER   B CA  1 
ATOM   5291 C  C   . SER   B 2 47  ? -31.437 -32.148  -20.383 1.00 72.30  ? 48   SER   B C   1 
ATOM   5292 O  O   . SER   B 2 47  ? -32.035 -33.221  -20.628 1.00 66.82  ? 48   SER   B O   1 
ATOM   5293 C  CB  . SER   B 2 47  ? -33.322 -31.005  -19.162 1.00 76.80  ? 48   SER   B CB  1 
ATOM   5294 O  OG  . SER   B 2 47  ? -34.425 -31.783  -19.604 1.00 81.34  ? 48   SER   B OG  1 
ATOM   5295 N  N   . LEU   B 2 48  ? -30.111 -32.020  -20.262 1.00 72.72  ? 49   LEU   B N   1 
ATOM   5296 C  CA  . LEU   B 2 48  ? -29.136 -33.142  -20.345 1.00 78.02  ? 49   LEU   B CA  1 
ATOM   5297 C  C   . LEU   B 2 48  ? -28.763 -33.605  -18.930 1.00 80.70  ? 49   LEU   B C   1 
ATOM   5298 O  O   . LEU   B 2 48  ? -27.883 -34.486  -18.807 1.00 86.07  ? 49   LEU   B O   1 
ATOM   5299 C  CB  . LEU   B 2 48  ? -27.895 -32.674  -21.117 1.00 76.79  ? 49   LEU   B CB  1 
ATOM   5300 C  CG  . LEU   B 2 48  ? -28.137 -32.143  -22.531 1.00 74.73  ? 49   LEU   B CG  1 
ATOM   5301 C  CD1 . LEU   B 2 48  ? -26.816 -31.817  -23.214 1.00 75.91  ? 49   LEU   B CD1 1 
ATOM   5302 C  CD2 . LEU   B 2 48  ? -28.931 -33.131  -23.371 1.00 71.26  ? 49   LEU   B CD2 1 
ATOM   5303 N  N   . SER   B 2 49  ? -29.403 -33.035  -17.904 1.00 79.61  ? 50   SER   B N   1 
ATOM   5304 C  CA  . SER   B 2 49  ? -29.141 -33.336  -16.474 1.00 80.89  ? 50   SER   B CA  1 
ATOM   5305 C  C   . SER   B 2 49  ? -30.363 -32.963  -15.631 1.00 84.33  ? 50   SER   B C   1 
ATOM   5306 O  O   . SER   B 2 49  ? -31.194 -32.162  -16.112 1.00 90.98  ? 50   SER   B O   1 
ATOM   5307 C  CB  . SER   B 2 49  ? -27.908 -32.621  -15.993 1.00 79.93  ? 50   SER   B CB  1 
ATOM   5308 O  OG  . SER   B 2 49  ? -27.334 -33.305  -14.891 1.00 74.25  ? 50   SER   B OG  1 
ATOM   5309 N  N   . GLY   B 2 50  ? -30.452 -33.523  -14.421 1.00 82.64  ? 51   GLY   B N   1 
ATOM   5310 C  CA  . GLY   B 2 50  ? -31.552 -33.284  -13.467 1.00 79.72  ? 51   GLY   B CA  1 
ATOM   5311 C  C   . GLY   B 2 50  ? -32.657 -34.317  -13.607 1.00 77.87  ? 51   GLY   B C   1 
ATOM   5312 O  O   . GLY   B 2 50  ? -32.545 -35.198  -14.483 1.00 71.13  ? 51   GLY   B O   1 
ATOM   5313 N  N   . ARG   B 2 51  ? -33.694 -34.199  -12.773 1.00 80.75  ? 52   ARG   B N   1 
ATOM   5314 C  CA  . ARG   B 2 51  ? -34.839 -35.147  -12.686 1.00 81.90  ? 52   ARG   B CA  1 
ATOM   5315 C  C   . ARG   B 2 51  ? -35.287 -35.553  -14.095 1.00 77.03  ? 52   ARG   B C   1 
ATOM   5316 O  O   . ARG   B 2 51  ? -35.228 -36.751  -14.410 1.00 72.33  ? 52   ARG   B O   1 
ATOM   5317 C  CB  . ARG   B 2 51  ? -35.998 -34.503  -11.917 1.00 85.04  ? 52   ARG   B CB  1 
ATOM   5318 C  CG  . ARG   B 2 51  ? -37.160 -35.443  -11.632 1.00 89.21  ? 52   ARG   B CG  1 
ATOM   5319 C  CD  . ARG   B 2 51  ? -38.283 -34.768  -10.864 1.00 92.68  ? 52   ARG   B CD  1 
ATOM   5320 N  NE  . ARG   B 2 51  ? -38.907 -35.684  -9.914  1.00 94.29  ? 52   ARG   B NE  1 
ATOM   5321 C  CZ  . ARG   B 2 51  ? -38.569 -35.820  -8.630  1.00 93.84  ? 52   ARG   B CZ  1 
ATOM   5322 N  NH1 . ARG   B 2 51  ? -37.602 -35.091  -8.093  1.00 93.57  ? 52   ARG   B NH1 1 
ATOM   5323 N  NH2 . ARG   B 2 51  ? -39.214 -36.694  -7.877  1.00 95.51  ? 52   ARG   B NH2 1 
ATOM   5324 N  N   . CYS   B 2 52  ? -35.703 -34.573  -14.900 1.00 79.55  ? 53   CYS   B N   1 
ATOM   5325 C  CA  . CYS   B 2 52  ? -36.424 -34.761  -16.185 1.00 81.46  ? 53   CYS   B CA  1 
ATOM   5326 C  C   . CYS   B 2 52  ? -35.516 -34.365  -17.359 1.00 77.30  ? 53   CYS   B C   1 
ATOM   5327 O  O   . CYS   B 2 52  ? -34.949 -33.250  -17.321 1.00 71.77  ? 53   CYS   B O   1 
ATOM   5328 C  CB  . CYS   B 2 52  ? -37.713 -33.946  -16.184 1.00 85.36  ? 53   CYS   B CB  1 
ATOM   5329 S  SG  . CYS   B 2 52  ? -38.913 -34.484  -17.431 1.00 100.83 ? 53   CYS   B SG  1 
ATOM   5330 N  N   . TRP   B 2 53  ? -35.383 -35.255  -18.350 1.00 75.58  ? 54   TRP   B N   1 
ATOM   5331 C  CA  . TRP   B 2 53  ? -34.546 -35.072  -19.568 1.00 79.79  ? 54   TRP   B CA  1 
ATOM   5332 C  C   . TRP   B 2 53  ? -35.450 -34.886  -20.789 1.00 81.00  ? 54   TRP   B C   1 
ATOM   5333 O  O   . TRP   B 2 53  ? -35.770 -35.889  -21.454 1.00 83.83  ? 54   TRP   B O   1 
ATOM   5334 C  CB  . TRP   B 2 53  ? -33.601 -36.264  -19.768 1.00 81.68  ? 54   TRP   B CB  1 
ATOM   5335 C  CG  . TRP   B 2 53  ? -32.551 -36.435  -18.714 1.00 81.37  ? 54   TRP   B CG  1 
ATOM   5336 C  CD1 . TRP   B 2 53  ? -32.197 -35.558  -17.728 1.00 81.37  ? 54   TRP   B CD1 1 
ATOM   5337 C  CD2 . TRP   B 2 53  ? -31.674 -37.566  -18.576 1.00 82.74  ? 54   TRP   B CD2 1 
ATOM   5338 N  NE1 . TRP   B 2 53  ? -31.175 -36.074  -16.977 1.00 81.79  ? 54   TRP   B NE1 1 
ATOM   5339 C  CE2 . TRP   B 2 53  ? -30.831 -37.303  -17.476 1.00 82.55  ? 54   TRP   B CE2 1 
ATOM   5340 C  CE3 . TRP   B 2 53  ? -31.523 -38.771  -19.273 1.00 81.34  ? 54   TRP   B CE3 1 
ATOM   5341 C  CZ2 . TRP   B 2 53  ? -29.856 -38.208  -17.059 1.00 82.76  ? 54   TRP   B CZ2 1 
ATOM   5342 C  CZ3 . TRP   B 2 53  ? -30.559 -39.663  -18.862 1.00 79.88  ? 54   TRP   B CZ3 1 
ATOM   5343 C  CH2 . TRP   B 2 53  ? -29.739 -39.383  -17.768 1.00 80.87  ? 54   TRP   B CH2 1 
ATOM   5344 N  N   . ALA   B 2 54  ? -35.842 -33.647  -21.075 1.00 81.61  ? 55   ALA   B N   1 
ATOM   5345 C  CA  . ALA   B 2 54  ? -36.792 -33.306  -22.155 1.00 83.04  ? 55   ALA   B CA  1 
ATOM   5346 C  C   . ALA   B 2 54  ? -36.236 -32.128  -22.958 1.00 81.51  ? 55   ALA   B C   1 
ATOM   5347 O  O   . ALA   B 2 54  ? -35.041 -31.805  -22.786 1.00 75.65  ? 55   ALA   B O   1 
ATOM   5348 C  CB  . ALA   B 2 54  ? -38.145 -33.013  -21.555 1.00 85.27  ? 55   ALA   B CB  1 
ATOM   5349 N  N   . GLY   B 2 55  ? -37.068 -31.535  -23.817 1.00 84.32  ? 56   GLY   B N   1 
ATOM   5350 C  CA  . GLY   B 2 55  ? -36.694 -30.404  -24.684 1.00 87.19  ? 56   GLY   B CA  1 
ATOM   5351 C  C   . GLY   B 2 55  ? -37.833 -29.419  -24.871 1.00 86.43  ? 56   GLY   B C   1 
ATOM   5352 O  O   . GLY   B 2 55  ? -38.973 -29.727  -24.468 1.00 82.83  ? 56   GLY   B O   1 
ATOM   5353 N  N   . SER   B 2 56  ? -37.520 -28.273  -25.476 1.00 85.76  ? 57   SER   B N   1 
ATOM   5354 C  CA  . SER   B 2 56  ? -38.463 -27.167  -25.764 1.00 85.30  ? 57   SER   B CA  1 
ATOM   5355 C  C   . SER   B 2 56  ? -38.028 -26.429  -27.034 1.00 85.22  ? 57   SER   B C   1 
ATOM   5356 O  O   . SER   B 2 56  ? -36.809 -26.381  -27.322 1.00 80.07  ? 57   SER   B O   1 
ATOM   5357 C  CB  . SER   B 2 56  ? -38.560 -26.230  -24.589 1.00 85.55  ? 57   SER   B CB  1 
ATOM   5358 O  OG  . SER   B 2 56  ? -37.267 -25.852  -24.143 1.00 85.01  ? 57   SER   B OG  1 
ATOM   5359 N  N   . LEU   B 2 57  ? -39.010 -25.899  -27.765 1.00 85.56  ? 58   LEU   B N   1 
ATOM   5360 C  CA  . LEU   B 2 57  ? -38.824 -25.000  -28.931 1.00 84.82  ? 58   LEU   B CA  1 
ATOM   5361 C  C   . LEU   B 2 57  ? -39.328 -23.612  -28.521 1.00 88.43  ? 58   LEU   B C   1 
ATOM   5362 O  O   . LEU   B 2 57  ? -40.315 -23.553  -27.758 1.00 84.48  ? 58   LEU   B O   1 
ATOM   5363 C  CB  . LEU   B 2 57  ? -39.599 -25.575  -30.120 1.00 83.93  ? 58   LEU   B CB  1 
ATOM   5364 C  CG  . LEU   B 2 57  ? -39.344 -27.055  -30.413 1.00 82.77  ? 58   LEU   B CG  1 
ATOM   5365 C  CD1 . LEU   B 2 57  ? -40.484 -27.659  -31.221 1.00 83.28  ? 58   LEU   B CD1 1 
ATOM   5366 C  CD2 . LEU   B 2 57  ? -38.015 -27.252  -31.127 1.00 81.56  ? 58   LEU   B CD2 1 
ATOM   5367 N  N   . TRP   B 2 58  ? -38.641 -22.552  -28.959 1.00 92.28  ? 59   TRP   B N   1 
ATOM   5368 C  CA  . TRP   B 2 58  ? -38.956 -21.137  -28.622 1.00 95.85  ? 59   TRP   B CA  1 
ATOM   5369 C  C   . TRP   B 2 58  ? -38.796 -20.259  -29.866 1.00 98.03  ? 59   TRP   B C   1 
ATOM   5370 O  O   . TRP   B 2 58  ? -37.813 -20.461  -30.607 1.00 95.97  ? 59   TRP   B O   1 
ATOM   5371 C  CB  . TRP   B 2 58  ? -38.065 -20.629  -27.482 1.00 98.53  ? 59   TRP   B CB  1 
ATOM   5372 C  CG  . TRP   B 2 58  ? -38.103 -21.473  -26.247 1.00 100.17 ? 59   TRP   B CG  1 
ATOM   5373 C  CD1 . TRP   B 2 58  ? -37.327 -22.561  -25.976 1.00 101.20 ? 59   TRP   B CD1 1 
ATOM   5374 C  CD2 . TRP   B 2 58  ? -38.961 -21.298  -25.106 1.00 105.08 ? 59   TRP   B CD2 1 
ATOM   5375 N  NE1 . TRP   B 2 58  ? -37.643 -23.076  -24.749 1.00 102.31 ? 59   TRP   B NE1 1 
ATOM   5376 C  CE2 . TRP   B 2 58  ? -38.642 -22.324  -24.191 1.00 103.86 ? 59   TRP   B CE2 1 
ATOM   5377 C  CE3 . TRP   B 2 58  ? -39.965 -20.381  -24.770 1.00 103.82 ? 59   TRP   B CE3 1 
ATOM   5378 C  CZ2 . TRP   B 2 58  ? -39.293 -22.458  -22.966 1.00 104.20 ? 59   TRP   B CZ2 1 
ATOM   5379 C  CZ3 . TRP   B 2 58  ? -40.608 -20.514  -23.559 1.00 104.30 ? 59   TRP   B CZ3 1 
ATOM   5380 C  CH2 . TRP   B 2 58  ? -40.274 -21.539  -22.671 1.00 105.65 ? 59   TRP   B CH2 1 
ATOM   5381 N  N   . LEU   B 2 59  ? -39.728 -19.320  -30.069 1.00 100.64 ? 60   LEU   B N   1 
ATOM   5382 C  CA  . LEU   B 2 59  ? -39.628 -18.238  -31.084 1.00 97.97  ? 60   LEU   B CA  1 
ATOM   5383 C  C   . LEU   B 2 59  ? -39.459 -16.901  -30.356 1.00 92.01  ? 60   LEU   B C   1 
ATOM   5384 O  O   . LEU   B 2 59  ? -40.276 -16.615  -29.462 1.00 89.44  ? 60   LEU   B O   1 
ATOM   5385 C  CB  . LEU   B 2 59  ? -40.883 -18.246  -31.964 1.00 99.69  ? 60   LEU   B CB  1 
ATOM   5386 C  CG  . LEU   B 2 59  ? -40.901 -17.231  -33.108 1.00 104.50 ? 60   LEU   B CG  1 
ATOM   5387 C  CD1 . LEU   B 2 59  ? -39.580 -17.214  -33.868 1.00 106.12 ? 60   LEU   B CD1 1 
ATOM   5388 C  CD2 . LEU   B 2 59  ? -42.052 -17.516  -34.061 1.00 107.38 ? 60   LEU   B CD2 1 
ATOM   5389 N  N   . PHE   B 2 60  ? -38.417 -16.143  -30.709 1.00 90.50  ? 61   PHE   B N   1 
ATOM   5390 C  CA  . PHE   B 2 60  ? -38.099 -14.800  -30.158 1.00 97.37  ? 61   PHE   B CA  1 
ATOM   5391 C  C   . PHE   B 2 60  ? -38.084 -13.771  -31.291 1.00 101.33 ? 61   PHE   B C   1 
ATOM   5392 O  O   . PHE   B 2 60  ? -37.028 -13.597  -31.937 1.00 99.45  ? 61   PHE   B O   1 
ATOM   5393 C  CB  . PHE   B 2 60  ? -36.763 -14.829  -29.416 1.00 103.70 ? 61   PHE   B CB  1 
ATOM   5394 C  CG  . PHE   B 2 60  ? -36.870 -15.335  -28.002 1.00 110.20 ? 61   PHE   B CG  1 
ATOM   5395 C  CD1 . PHE   B 2 60  ? -36.842 -16.694  -27.731 1.00 112.55 ? 61   PHE   B CD1 1 
ATOM   5396 C  CD2 . PHE   B 2 60  ? -37.018 -14.450  -26.946 1.00 112.27 ? 61   PHE   B CD2 1 
ATOM   5397 C  CE1 . PHE   B 2 60  ? -36.951 -17.157  -26.429 1.00 115.14 ? 61   PHE   B CE1 1 
ATOM   5398 C  CE2 . PHE   B 2 60  ? -37.126 -14.915  -25.646 1.00 114.36 ? 61   PHE   B CE2 1 
ATOM   5399 C  CZ  . PHE   B 2 60  ? -37.092 -16.267  -25.390 1.00 115.45 ? 61   PHE   B CZ  1 
ATOM   5400 N  N   . LYS   B 2 61  ? -39.225 -13.107  -31.509 1.00 103.83 ? 62   LYS   B N   1 
ATOM   5401 C  CA  . LYS   B 2 61  ? -39.383 -12.010  -32.503 1.00 100.78 ? 62   LYS   B CA  1 
ATOM   5402 C  C   . LYS   B 2 61  ? -38.494 -10.829  -32.095 1.00 95.16  ? 62   LYS   B C   1 
ATOM   5403 O  O   . LYS   B 2 61  ? -38.176 -10.012  -32.976 1.00 89.52  ? 62   LYS   B O   1 
ATOM   5404 C  CB  . LYS   B 2 61  ? -40.857 -11.620  -32.645 1.00 101.66 ? 62   LYS   B CB  1 
ATOM   5405 C  CG  . LYS   B 2 61  ? -41.652 -12.538  -33.562 1.00 104.85 ? 62   LYS   B CG  1 
ATOM   5406 C  CD  . LYS   B 2 61  ? -43.136 -12.254  -33.606 1.00 105.77 ? 62   LYS   B CD  1 
ATOM   5407 C  CE  . LYS   B 2 61  ? -43.773 -12.709  -34.901 1.00 106.61 ? 62   LYS   B CE  1 
ATOM   5408 N  NZ  . LYS   B 2 61  ? -45.110 -13.301  -34.668 1.00 111.23 ? 62   LYS   B NZ  1 
ATOM   5409 N  N   . ASP   B 2 62  ? -38.116 -10.755  -30.812 1.00 94.79  ? 63   ASP   B N   1 
ATOM   5410 C  CA  . ASP   B 2 62  ? -37.050 -9.860   -30.287 1.00 98.18  ? 63   ASP   B CA  1 
ATOM   5411 C  C   . ASP   B 2 62  ? -35.795 -10.697  -30.033 1.00 101.37 ? 63   ASP   B C   1 
ATOM   5412 O  O   . ASP   B 2 62  ? -35.651 -11.295  -28.968 1.00 98.68  ? 63   ASP   B O   1 
ATOM   5413 C  CB  . ASP   B 2 62  ? -37.521 -9.124   -29.028 1.00 96.05  ? 63   ASP   B CB  1 
ATOM   5414 C  CG  . ASP   B 2 62  ? -36.541 -8.088   -28.496 1.00 98.31  ? 63   ASP   B CG  1 
ATOM   5415 O  OD1 . ASP   B 2 62  ? -35.500 -7.852   -29.157 1.00 94.62  ? 63   ASP   B OD1 1 
ATOM   5416 O  OD2 . ASP   B 2 62  ? -36.824 -7.521   -27.421 1.00 97.39  ? 63   ASP   B OD2 1 
ATOM   5417 N  N   . PRO   B 2 63  ? -34.855 -10.780  -31.005 1.00 102.70 ? 64   PRO   B N   1 
ATOM   5418 C  CA  . PRO   B 2 63  ? -33.591 -11.490  -30.805 1.00 103.24 ? 64   PRO   B CA  1 
ATOM   5419 C  C   . PRO   B 2 63  ? -32.885 -11.173  -29.477 1.00 104.09 ? 64   PRO   B C   1 
ATOM   5420 O  O   . PRO   B 2 63  ? -32.386 -12.094  -28.859 1.00 109.72 ? 64   PRO   B O   1 
ATOM   5421 C  CB  . PRO   B 2 63  ? -32.723 -10.993  -31.972 1.00 103.18 ? 64   PRO   B CB  1 
ATOM   5422 C  CG  . PRO   B 2 63  ? -33.716 -10.691  -33.072 1.00 105.84 ? 64   PRO   B CG  1 
ATOM   5423 C  CD  . PRO   B 2 63  ? -34.967 -10.217  -32.360 1.00 105.53 ? 64   PRO   B CD  1 
ATOM   5424 N  N   . CYS   B 2 64  ? -32.868 -9.897   -29.077 1.00 101.68 ? 65   CYS   B N   1 
ATOM   5425 C  CA  . CYS   B 2 64  ? -32.086 -9.372   -27.922 1.00 99.97  ? 65   CYS   B CA  1 
ATOM   5426 C  C   . CYS   B 2 64  ? -32.798 -9.656   -26.590 1.00 97.12  ? 65   CYS   B C   1 
ATOM   5427 O  O   . CYS   B 2 64  ? -32.154 -9.479   -25.540 1.00 91.50  ? 65   CYS   B O   1 
ATOM   5428 C  CB  . CYS   B 2 64  ? -31.820 -7.879   -28.083 1.00 101.63 ? 65   CYS   B CB  1 
ATOM   5429 S  SG  . CYS   B 2 64  ? -30.642 -7.505   -29.409 1.00 109.42 ? 65   CYS   B SG  1 
ATOM   5430 N  N   . ALA   B 2 65  ? -34.063 -10.092  -26.624 1.00 100.09 ? 66   ALA   B N   1 
ATOM   5431 C  CA  . ALA   B 2 65  ? -34.871 -10.439  -25.429 1.00 104.05 ? 66   ALA   B CA  1 
ATOM   5432 C  C   . ALA   B 2 65  ? -34.486 -11.830  -24.909 1.00 109.36 ? 66   ALA   B C   1 
ATOM   5433 O  O   . ALA   B 2 65  ? -34.543 -12.030  -23.678 1.00 113.47 ? 66   ALA   B O   1 
ATOM   5434 C  CB  . ALA   B 2 65  ? -36.343 -10.374  -25.755 1.00 104.33 ? 66   ALA   B CB  1 
ATOM   5435 N  N   . ALA   B 2 66  ? -34.136 -12.753  -25.815 1.00 111.44 ? 67   ALA   B N   1 
ATOM   5436 C  CA  . ALA   B 2 66  ? -33.719 -14.148  -25.521 1.00 108.47 ? 67   ALA   B CA  1 
ATOM   5437 C  C   . ALA   B 2 66  ? -32.438 -14.141  -24.686 1.00 104.79 ? 67   ALA   B C   1 
ATOM   5438 O  O   . ALA   B 2 66  ? -31.591 -13.266  -24.861 1.00 104.96 ? 67   ALA   B O   1 
ATOM   5439 C  CB  . ALA   B 2 66  ? -33.527 -14.906  -26.813 1.00 108.33 ? 67   ALA   B CB  1 
ATOM   5440 N  N   . PRO   B 2 67  ? -32.218 -15.126  -23.783 1.00 96.78  ? 68   PRO   B N   1 
ATOM   5441 C  CA  . PRO   B 2 67  ? -33.036 -16.339  -23.698 1.00 93.60  ? 68   PRO   B CA  1 
ATOM   5442 C  C   . PRO   B 2 67  ? -34.272 -16.278  -22.784 1.00 92.11  ? 68   PRO   B C   1 
ATOM   5443 O  O   . PRO   B 2 67  ? -34.947 -17.284  -22.678 1.00 89.31  ? 68   PRO   B O   1 
ATOM   5444 C  CB  . PRO   B 2 67  ? -32.017 -17.332  -23.117 1.00 93.79  ? 68   PRO   B CB  1 
ATOM   5445 C  CG  . PRO   B 2 67  ? -31.160 -16.501  -22.187 1.00 95.59  ? 68   PRO   B CG  1 
ATOM   5446 C  CD  . PRO   B 2 67  ? -31.135 -15.112  -22.788 1.00 96.61  ? 68   PRO   B CD  1 
ATOM   5447 N  N   . ASN   B 2 68  ? -34.543 -15.117  -22.175 1.00 96.19  ? 69   ASN   B N   1 
ATOM   5448 C  CA  . ASN   B 2 68  ? -35.589 -14.897  -21.134 1.00 98.07  ? 69   ASN   B CA  1 
ATOM   5449 C  C   . ASN   B 2 68  ? -36.947 -15.422  -21.622 1.00 98.24  ? 69   ASN   B C   1 
ATOM   5450 O  O   . ASN   B 2 68  ? -37.455 -14.889  -22.622 1.00 97.28  ? 69   ASN   B O   1 
ATOM   5451 C  CB  . ASN   B 2 68  ? -35.673 -13.416  -20.752 1.00 100.13 ? 69   ASN   B CB  1 
ATOM   5452 C  CG  . ASN   B 2 68  ? -36.604 -13.131  -19.591 1.00 102.75 ? 69   ASN   B CG  1 
ATOM   5453 O  OD1 . ASN   B 2 68  ? -37.426 -13.965  -19.215 1.00 102.05 ? 69   ASN   B OD1 1 
ATOM   5454 N  ND2 . ASN   B 2 68  ? -36.487 -11.945  -19.018 1.00 106.24 ? 69   ASN   B ND2 1 
ATOM   5455 N  N   . GLU   B 2 69  ? -37.532 -16.381  -20.892 1.00 101.52 ? 70   GLU   B N   1 
ATOM   5456 C  CA  . GLU   B 2 69  ? -38.782 -17.111  -21.257 1.00 106.88 ? 70   GLU   B CA  1 
ATOM   5457 C  C   . GLU   B 2 69  ? -39.983 -16.156  -21.280 1.00 109.52 ? 70   GLU   B C   1 
ATOM   5458 O  O   . GLU   B 2 69  ? -40.969 -16.474  -21.973 1.00 107.77 ? 70   GLU   B O   1 
ATOM   5459 C  CB  . GLU   B 2 69  ? -39.090 -18.234  -20.260 1.00 107.75 ? 70   GLU   B CB  1 
ATOM   5460 C  CG  . GLU   B 2 69  ? -37.944 -19.207  -20.027 1.00 108.62 ? 70   GLU   B CG  1 
ATOM   5461 C  CD  . GLU   B 2 69  ? -36.953 -18.808  -18.943 1.00 109.10 ? 70   GLU   B CD  1 
ATOM   5462 O  OE1 . GLU   B 2 69  ? -35.743 -19.057  -19.129 1.00 108.84 ? 70   GLU   B OE1 1 
ATOM   5463 O  OE2 . GLU   B 2 69  ? -37.387 -18.253  -17.916 1.00 106.60 ? 70   GLU   B OE2 1 
ATOM   5464 N  N   . GLY   B 2 70  ? -39.917 -15.058  -20.518 1.00 114.92 ? 71   GLY   B N   1 
ATOM   5465 C  CA  . GLY   B 2 70  ? -41.025 -14.106  -20.304 1.00 116.75 ? 71   GLY   B CA  1 
ATOM   5466 C  C   . GLY   B 2 70  ? -41.275 -13.209  -21.506 1.00 116.04 ? 71   GLY   B C   1 
ATOM   5467 O  O   . GLY   B 2 70  ? -42.455 -12.973  -21.819 1.00 117.28 ? 71   GLY   B O   1 
ATOM   5468 N  N   . PHE   B 2 71  ? -40.215 -12.706  -22.146 1.00 112.28 ? 72   PHE   B N   1 
ATOM   5469 C  CA  . PHE   B 2 71  ? -40.289 -11.841  -23.355 1.00 111.91 ? 72   PHE   B CA  1 
ATOM   5470 C  C   . PHE   B 2 71  ? -40.250 -12.741  -24.595 1.00 105.94 ? 72   PHE   B C   1 
ATOM   5471 O  O   . PHE   B 2 71  ? -39.344 -12.606  -25.443 1.00 97.22  ? 72   PHE   B O   1 
ATOM   5472 C  CB  . PHE   B 2 71  ? -39.182 -10.783  -23.323 1.00 117.30 ? 72   PHE   B CB  1 
ATOM   5473 C  CG  . PHE   B 2 71  ? -39.085 -10.013  -22.028 1.00 123.51 ? 72   PHE   B CG  1 
ATOM   5474 C  CD1 . PHE   B 2 71  ? -40.215 -9.740   -21.268 1.00 122.48 ? 72   PHE   B CD1 1 
ATOM   5475 C  CD2 . PHE   B 2 71  ? -37.858 -9.554   -21.571 1.00 125.18 ? 72   PHE   B CD2 1 
ATOM   5476 C  CE1 . PHE   B 2 71  ? -40.117 -9.037   -20.079 1.00 122.16 ? 72   PHE   B CE1 1 
ATOM   5477 C  CE2 . PHE   B 2 71  ? -37.764 -8.846   -20.382 1.00 126.19 ? 72   PHE   B CE2 1 
ATOM   5478 C  CZ  . PHE   B 2 71  ? -38.893 -8.589   -19.638 1.00 125.36 ? 72   PHE   B CZ  1 
ATOM   5479 N  N   . CYS   B 2 72  ? -41.249 -13.624  -24.685 1.00 104.75 ? 73   CYS   B N   1 
ATOM   5480 C  CA  . CYS   B 2 72  ? -41.335 -14.765  -25.632 1.00 104.85 ? 73   CYS   B CA  1 
ATOM   5481 C  C   . CYS   B 2 72  ? -42.506 -14.564  -26.602 1.00 106.90 ? 73   CYS   B C   1 
ATOM   5482 O  O   . CYS   B 2 72  ? -43.617 -14.232  -26.131 1.00 108.04 ? 73   CYS   B O   1 
ATOM   5483 C  CB  . CYS   B 2 72  ? -41.517 -16.064  -24.857 1.00 99.65  ? 73   CYS   B CB  1 
ATOM   5484 S  SG  . CYS   B 2 72  ? -41.837 -17.503  -25.905 1.00 97.31  ? 73   CYS   B SG  1 
ATOM   5485 N  N   . SER   B 2 73  ? -42.261 -14.772  -27.899 1.00 102.58 ? 74   SER   B N   1 
ATOM   5486 C  CA  . SER   B 2 73  ? -43.291 -14.795  -28.970 1.00 101.83 ? 74   SER   B CA  1 
ATOM   5487 C  C   . SER   B 2 73  ? -44.113 -16.088  -28.851 1.00 102.74 ? 74   SER   B C   1 
ATOM   5488 O  O   . SER   B 2 73  ? -45.358 -15.992  -28.831 1.00 106.56 ? 74   SER   B O   1 
ATOM   5489 C  CB  . SER   B 2 73  ? -42.662 -14.649  -30.338 1.00 102.22 ? 74   SER   B CB  1 
ATOM   5490 O  OG  . SER   B 2 73  ? -41.604 -13.697  -30.315 1.00 96.46  ? 74   SER   B OG  1 
ATOM   5491 N  N   . ALA   B 2 74  ? -43.440 -17.244  -28.755 1.00 100.14 ? 75   ALA   B N   1 
ATOM   5492 C  CA  . ALA   B 2 74  ? -44.059 -18.587  -28.621 1.00 97.83  ? 75   ALA   B CA  1 
ATOM   5493 C  C   . ALA   B 2 74  ? -43.065 -19.590  -28.016 1.00 98.66  ? 75   ALA   B C   1 
ATOM   5494 O  O   . ALA   B 2 74  ? -41.842 -19.360  -28.132 1.00 101.58 ? 75   ALA   B O   1 
ATOM   5495 C  CB  . ALA   B 2 74  ? -44.545 -19.062  -29.968 1.00 96.42  ? 75   ALA   B CB  1 
ATOM   5496 N  N   . GLY   B 2 75  ? -43.582 -20.666  -27.410 1.00 95.54  ? 76   GLY   B N   1 
ATOM   5497 C  CA  . GLY   B 2 75  ? -42.790 -21.750  -26.793 1.00 94.76  ? 76   GLY   B CA  1 
ATOM   5498 C  C   . GLY   B 2 75  ? -43.634 -22.979  -26.482 1.00 95.00  ? 76   GLY   B C   1 
ATOM   5499 O  O   . GLY   B 2 75  ? -44.831 -22.810  -26.167 1.00 96.11  ? 76   GLY   B O   1 
ATOM   5500 N  N   . VAL   B 2 76  ? -43.038 -24.176  -26.566 1.00 92.40  ? 77   VAL   B N   1 
ATOM   5501 C  CA  . VAL   B 2 76  ? -43.700 -25.474  -26.227 1.00 92.18  ? 77   VAL   B CA  1 
ATOM   5502 C  C   . VAL   B 2 76  ? -42.644 -26.463  -25.713 1.00 94.53  ? 77   VAL   B C   1 
ATOM   5503 O  O   . VAL   B 2 76  ? -41.448 -26.252  -25.998 1.00 88.65  ? 77   VAL   B O   1 
ATOM   5504 C  CB  . VAL   B 2 76  ? -44.470 -26.045  -27.436 1.00 89.28  ? 77   VAL   B CB  1 
ATOM   5505 C  CG1 . VAL   B 2 76  ? -43.533 -26.567  -28.518 1.00 89.21  ? 77   VAL   B CG1 1 
ATOM   5506 C  CG2 . VAL   B 2 76  ? -45.465 -27.121  -27.023 1.00 86.75  ? 77   VAL   B CG2 1 
ATOM   5507 N  N   . GLN   B 2 77  ? -43.090 -27.494  -24.984 1.00 97.21  ? 78   GLN   B N   1 
ATOM   5508 C  CA  . GLN   B 2 77  ? -42.273 -28.644  -24.510 1.00 97.28  ? 78   GLN   B CA  1 
ATOM   5509 C  C   . GLN   B 2 77  ? -42.414 -29.815  -25.491 1.00 91.32  ? 78   GLN   B C   1 
ATOM   5510 O  O   . GLN   B 2 77  ? -43.555 -30.111  -25.894 1.00 88.96  ? 78   GLN   B O   1 
ATOM   5511 C  CB  . GLN   B 2 77  ? -42.719 -29.086  -23.113 1.00 101.91 ? 78   GLN   B CB  1 
ATOM   5512 C  CG  . GLN   B 2 77  ? -42.151 -28.236  -21.983 1.00 109.00 ? 78   GLN   B CG  1 
ATOM   5513 C  CD  . GLN   B 2 77  ? -41.208 -29.001  -21.086 1.00 116.82 ? 78   GLN   B CD  1 
ATOM   5514 O  OE1 . GLN   B 2 77  ? -41.604 -29.943  -20.401 1.00 124.17 ? 78   GLN   B OE1 1 
ATOM   5515 N  NE2 . GLN   B 2 77  ? -39.949 -28.592  -21.068 1.00 119.99 ? 78   GLN   B NE2 1 
ATOM   5516 N  N   . THR   B 2 78  ? -41.289 -30.444  -25.846 1.00 89.80  ? 79   THR   B N   1 
ATOM   5517 C  CA  . THR   B 2 78  ? -41.207 -31.757  -26.540 1.00 88.62  ? 79   THR   B CA  1 
ATOM   5518 C  C   . THR   B 2 78  ? -41.055 -32.853  -25.477 1.00 85.36  ? 79   THR   B C   1 
ATOM   5519 O  O   . THR   B 2 78  ? -40.536 -32.539  -24.390 1.00 84.88  ? 79   THR   B O   1 
ATOM   5520 C  CB  . THR   B 2 78  ? -40.047 -31.778  -27.543 1.00 92.13  ? 79   THR   B CB  1 
ATOM   5521 O  OG1 . THR   B 2 78  ? -38.820 -31.698  -26.817 1.00 96.73  ? 79   THR   B OG1 1 
ATOM   5522 C  CG2 . THR   B 2 78  ? -40.099 -30.640  -28.538 1.00 95.02  ? 79   THR   B CG2 1 
ATOM   5523 N  N   . GLU   B 2 79  ? -41.510 -34.074  -25.773 1.00 81.80  ? 80   GLU   B N   1 
ATOM   5524 C  CA  . GLU   B 2 79  ? -41.413 -35.252  -24.865 1.00 82.19  ? 80   GLU   B CA  1 
ATOM   5525 C  C   . GLU   B 2 79  ? -39.955 -35.443  -24.419 1.00 81.26  ? 80   GLU   B C   1 
ATOM   5526 O  O   . GLU   B 2 79  ? -39.734 -35.627  -23.208 1.00 80.50  ? 80   GLU   B O   1 
ATOM   5527 C  CB  . GLU   B 2 79  ? -41.962 -36.519  -25.533 1.00 81.47  ? 80   GLU   B CB  1 
ATOM   5528 C  CG  . GLU   B 2 79  ? -41.546 -36.685  -26.987 1.00 85.75  ? 80   GLU   B CG  1 
ATOM   5529 C  CD  . GLU   B 2 79  ? -41.662 -38.086  -27.562 1.00 86.65  ? 80   GLU   B CD  1 
ATOM   5530 O  OE1 . GLU   B 2 79  ? -42.178 -38.983  -26.853 1.00 80.50  ? 80   GLU   B OE1 1 
ATOM   5531 O  OE2 . GLU   B 2 79  ? -41.234 -38.273  -28.726 1.00 84.93  ? 80   GLU   B OE2 1 
ATOM   5532 N  N   . ALA   B 2 80  ? -39.004 -35.365  -25.357 1.00 78.83  ? 81   ALA   B N   1 
ATOM   5533 C  CA  . ALA   B 2 80  ? -37.570 -35.686  -25.158 1.00 76.63  ? 81   ALA   B CA  1 
ATOM   5534 C  C   . ALA   B 2 80  ? -36.700 -34.511  -25.630 1.00 77.05  ? 81   ALA   B C   1 
ATOM   5535 O  O   . ALA   B 2 80  ? -37.267 -33.456  -25.984 1.00 76.58  ? 81   ALA   B O   1 
ATOM   5536 C  CB  . ALA   B 2 80  ? -37.235 -36.964  -25.892 1.00 74.54  ? 81   ALA   B CB  1 
ATOM   5537 N  N   . GLY   B 2 81  ? -35.375 -34.694  -25.637 1.00 72.61  ? 82   GLY   B N   1 
ATOM   5538 C  CA  . GLY   B 2 81  ? -34.385 -33.648  -25.956 1.00 68.20  ? 82   GLY   B CA  1 
ATOM   5539 C  C   . GLY   B 2 81  ? -34.387 -33.262  -27.427 1.00 68.79  ? 82   GLY   B C   1 
ATOM   5540 O  O   . GLY   B 2 81  ? -35.050 -33.945  -28.230 1.00 70.73  ? 82   GLY   B O   1 
ATOM   5541 N  N   . VAL   B 2 82  ? -33.645 -32.202  -27.756 1.00 67.14  ? 83   VAL   B N   1 
ATOM   5542 C  CA  . VAL   B 2 82  ? -33.496 -31.603  -29.112 1.00 69.52  ? 83   VAL   B CA  1 
ATOM   5543 C  C   . VAL   B 2 82  ? -32.018 -31.724  -29.497 1.00 71.15  ? 83   VAL   B C   1 
ATOM   5544 O  O   . VAL   B 2 82  ? -31.220 -30.853  -29.078 1.00 69.95  ? 83   VAL   B O   1 
ATOM   5545 C  CB  . VAL   B 2 82  ? -33.974 -30.133  -29.123 1.00 75.08  ? 83   VAL   B CB  1 
ATOM   5546 C  CG1 . VAL   B 2 82  ? -33.709 -29.439  -30.453 1.00 75.70  ? 83   VAL   B CG1 1 
ATOM   5547 C  CG2 . VAL   B 2 82  ? -35.446 -30.011  -28.754 1.00 76.34  ? 83   VAL   B CG2 1 
ATOM   5548 N  N   . ALA   B 2 83  ? -31.665 -32.782  -30.232 1.00 73.95  ? 84   ALA   B N   1 
ATOM   5549 C  CA  . ALA   B 2 83  ? -30.295 -33.046  -30.734 1.00 73.25  ? 84   ALA   B CA  1 
ATOM   5550 C  C   . ALA   B 2 83  ? -29.967 -32.050  -31.850 1.00 73.06  ? 84   ALA   B C   1 
ATOM   5551 O  O   . ALA   B 2 83  ? -28.858 -31.484  -31.841 1.00 75.53  ? 84   ALA   B O   1 
ATOM   5552 C  CB  . ALA   B 2 83  ? -30.186 -34.468  -31.219 1.00 72.69  ? 84   ALA   B CB  1 
ATOM   5553 N  N   . ASP   B 2 84  ? -30.913 -31.855  -32.773 1.00 73.50  ? 85   ASP   B N   1 
ATOM   5554 C  CA  . ASP   B 2 84  ? -30.825 -30.885  -33.897 1.00 76.37  ? 85   ASP   B CA  1 
ATOM   5555 C  C   . ASP   B 2 84  ? -32.245 -30.407  -34.221 1.00 75.26  ? 85   ASP   B C   1 
ATOM   5556 O  O   . ASP   B 2 84  ? -33.212 -31.104  -33.846 1.00 75.18  ? 85   ASP   B O   1 
ATOM   5557 C  CB  . ASP   B 2 84  ? -30.143 -31.522  -35.117 1.00 75.71  ? 85   ASP   B CB  1 
ATOM   5558 C  CG  . ASP   B 2 84  ? -29.553 -30.551  -36.132 1.00 72.60  ? 85   ASP   B CG  1 
ATOM   5559 O  OD1 . ASP   B 2 84  ? -29.204 -29.416  -35.741 1.00 71.39  ? 85   ASP   B OD1 1 
ATOM   5560 O  OD2 . ASP   B 2 84  ? -29.426 -30.949  -37.312 1.00 69.32  ? 85   ASP   B OD2 1 
ATOM   5561 N  N   . LEU   B 2 85  ? -32.364 -29.250  -34.871 1.00 74.68  ? 86   LEU   B N   1 
ATOM   5562 C  CA  . LEU   B 2 85  ? -33.610 -28.824  -35.560 1.00 77.25  ? 86   LEU   B CA  1 
ATOM   5563 C  C   . LEU   B 2 85  ? -33.239 -27.999  -36.794 1.00 79.38  ? 86   LEU   B C   1 
ATOM   5564 O  O   . LEU   B 2 85  ? -32.030 -27.788  -37.036 1.00 73.62  ? 86   LEU   B O   1 
ATOM   5565 C  CB  . LEU   B 2 85  ? -34.512 -28.031  -34.604 1.00 73.92  ? 86   LEU   B CB  1 
ATOM   5566 C  CG  . LEU   B 2 85  ? -33.903 -26.784  -33.960 1.00 72.73  ? 86   LEU   B CG  1 
ATOM   5567 C  CD1 . LEU   B 2 85  ? -33.686 -25.668  -34.972 1.00 73.10  ? 86   LEU   B CD1 1 
ATOM   5568 C  CD2 . LEU   B 2 85  ? -34.782 -26.287  -32.822 1.00 72.16  ? 86   LEU   B CD2 1 
ATOM   5569 N  N   . THR   B 2 86  ? -34.254 -27.570  -37.544 1.00 81.66  ? 87   THR   B N   1 
ATOM   5570 C  CA  . THR   B 2 86  ? -34.142 -26.525  -38.593 1.00 83.64  ? 87   THR   B CA  1 
ATOM   5571 C  C   . THR   B 2 86  ? -35.543 -26.041  -38.978 1.00 82.44  ? 87   THR   B C   1 
ATOM   5572 O  O   . THR   B 2 86  ? -36.522 -26.802  -38.779 1.00 78.31  ? 87   THR   B O   1 
ATOM   5573 C  CB  . THR   B 2 86  ? -33.348 -27.022  -39.811 1.00 84.43  ? 87   THR   B CB  1 
ATOM   5574 O  OG1 . THR   B 2 86  ? -33.038 -25.880  -40.611 1.00 84.63  ? 87   THR   B OG1 1 
ATOM   5575 C  CG2 . THR   B 2 86  ? -34.087 -28.053  -40.638 1.00 81.21  ? 87   THR   B CG2 1 
ATOM   5576 N  N   . TRP   B 2 87  ? -35.610 -24.808  -39.486 1.00 80.55  ? 88   TRP   B N   1 
ATOM   5577 C  CA  . TRP   B 2 87  ? -36.794 -24.221  -40.164 1.00 79.20  ? 88   TRP   B CA  1 
ATOM   5578 C  C   . TRP   B 2 87  ? -37.196 -25.110  -41.348 1.00 81.81  ? 88   TRP   B C   1 
ATOM   5579 O  O   . TRP   B 2 87  ? -36.291 -25.555  -42.082 1.00 83.82  ? 88   TRP   B O   1 
ATOM   5580 C  CB  . TRP   B 2 87  ? -36.484 -22.794  -40.635 1.00 75.67  ? 88   TRP   B CB  1 
ATOM   5581 C  CG  . TRP   B 2 87  ? -36.510 -21.747  -39.562 1.00 72.81  ? 88   TRP   B CG  1 
ATOM   5582 C  CD1 . TRP   B 2 87  ? -35.456 -21.010  -39.103 1.00 72.07  ? 88   TRP   B CD1 1 
ATOM   5583 C  CD2 . TRP   B 2 87  ? -37.665 -21.288  -38.836 1.00 69.40  ? 88   TRP   B CD2 1 
ATOM   5584 N  NE1 . TRP   B 2 87  ? -35.873 -20.135  -38.135 1.00 72.72  ? 88   TRP   B NE1 1 
ATOM   5585 C  CE2 . TRP   B 2 87  ? -37.224 -20.279  -37.953 1.00 70.04  ? 88   TRP   B CE2 1 
ATOM   5586 C  CE3 . TRP   B 2 87  ? -39.022 -21.627  -38.846 1.00 68.75  ? 88   TRP   B CE3 1 
ATOM   5587 C  CZ2 . TRP   B 2 87  ? -38.096 -19.613  -37.091 1.00 69.73  ? 88   TRP   B CZ2 1 
ATOM   5588 C  CZ3 . TRP   B 2 87  ? -39.883 -20.971  -37.994 1.00 68.79  ? 88   TRP   B CZ3 1 
ATOM   5589 C  CH2 . TRP   B 2 87  ? -39.423 -19.979  -37.126 1.00 69.54  ? 88   TRP   B CH2 1 
ATOM   5590 N  N   . VAL   B 2 88  ? -38.496 -25.373  -41.501 1.00 85.75  ? 89   VAL   B N   1 
ATOM   5591 C  CA  . VAL   B 2 88  ? -39.138 -25.830  -42.771 1.00 90.75  ? 89   VAL   B CA  1 
ATOM   5592 C  C   . VAL   B 2 88  ? -39.861 -24.613  -43.362 1.00 96.04  ? 89   VAL   B C   1 
ATOM   5593 O  O   . VAL   B 2 88  ? -41.052 -24.409  -43.040 1.00 102.18 ? 89   VAL   B O   1 
ATOM   5594 C  CB  . VAL   B 2 88  ? -40.089 -27.022  -42.541 1.00 92.34  ? 89   VAL   B CB  1 
ATOM   5595 C  CG1 . VAL   B 2 88  ? -40.836 -27.425  -43.807 1.00 89.12  ? 89   VAL   B CG1 1 
ATOM   5596 C  CG2 . VAL   B 2 88  ? -39.350 -28.217  -41.957 1.00 93.47  ? 89   VAL   B CG2 1 
ATOM   5597 N  N   . GLY   B 2 89  ? -39.149 -23.817  -44.163 1.00 94.72  ? 90   GLY   B N   1 
ATOM   5598 C  CA  . GLY   B 2 89  ? -39.642 -22.538  -44.705 1.00 97.22  ? 90   GLY   B CA  1 
ATOM   5599 C  C   . GLY   B 2 89  ? -39.746 -21.478  -43.620 1.00 103.38 ? 90   GLY   B C   1 
ATOM   5600 O  O   . GLY   B 2 89  ? -38.692 -21.096  -43.068 1.00 107.08 ? 90   GLY   B O   1 
ATOM   5601 N  N   . GLU   B 2 90  ? -40.972 -21.034  -43.317 1.00 106.22 ? 91   GLU   B N   1 
ATOM   5602 C  CA  . GLU   B 2 90  ? -41.264 -19.847  -42.464 1.00 104.10 ? 91   GLU   B CA  1 
ATOM   5603 C  C   . GLU   B 2 90  ? -42.101 -20.236  -41.239 1.00 99.36  ? 91   GLU   B C   1 
ATOM   5604 O  O   . GLU   B 2 90  ? -41.888 -19.616  -40.179 1.00 93.06  ? 91   GLU   B O   1 
ATOM   5605 C  CB  . GLU   B 2 90  ? -41.997 -18.786  -43.290 1.00 106.70 ? 91   GLU   B CB  1 
ATOM   5606 C  CG  . GLU   B 2 90  ? -41.186 -18.271  -44.464 1.00 107.55 ? 91   GLU   B CG  1 
ATOM   5607 C  CD  . GLU   B 2 90  ? -39.897 -17.576  -44.065 1.00 109.17 ? 91   GLU   B CD  1 
ATOM   5608 O  OE1 . GLU   B 2 90  ? -39.970 -16.617  -43.272 1.00 111.93 ? 91   GLU   B OE1 1 
ATOM   5609 O  OE2 . GLU   B 2 90  ? -38.824 -18.004  -44.532 1.00 111.23 ? 91   GLU   B OE2 1 
ATOM   5610 N  N   . ARG   B 2 91  ? -43.027 -21.192  -41.387 1.00 98.84  ? 92   ARG   B N   1 
ATOM   5611 C  CA  . ARG   B 2 91  ? -43.971 -21.630  -40.322 1.00 101.77 ? 92   ARG   B CA  1 
ATOM   5612 C  C   . ARG   B 2 91  ? -43.444 -22.875  -39.592 1.00 100.68 ? 92   ARG   B C   1 
ATOM   5613 O  O   . ARG   B 2 91  ? -43.730 -22.993  -38.386 1.00 99.42  ? 92   ARG   B O   1 
ATOM   5614 C  CB  . ARG   B 2 91  ? -45.356 -21.929  -40.911 1.00 107.53 ? 92   ARG   B CB  1 
ATOM   5615 C  CG  . ARG   B 2 91  ? -46.220 -20.698  -41.147 1.00 111.21 ? 92   ARG   B CG  1 
ATOM   5616 C  CD  . ARG   B 2 91  ? -46.609 -19.998  -39.858 1.00 114.79 ? 92   ARG   B CD  1 
ATOM   5617 N  NE  . ARG   B 2 91  ? -46.626 -18.547  -40.005 1.00 119.00 ? 92   ARG   B NE  1 
ATOM   5618 C  CZ  . ARG   B 2 91  ? -47.680 -17.817  -40.374 1.00 122.75 ? 92   ARG   B CZ  1 
ATOM   5619 N  NH1 . ARG   B 2 91  ? -47.561 -16.502  -40.468 1.00 121.62 ? 92   ARG   B NH1 1 
ATOM   5620 N  NH2 . ARG   B 2 91  ? -48.843 -18.386  -40.644 1.00 124.79 ? 92   ARG   B NH2 1 
ATOM   5621 N  N   . GLY   B 2 92  ? -42.719 -23.761  -40.289 1.00 97.46  ? 93   GLY   B N   1 
ATOM   5622 C  CA  . GLY   B 2 92  ? -42.398 -25.130  -39.830 1.00 95.03  ? 93   GLY   B CA  1 
ATOM   5623 C  C   . GLY   B 2 92  ? -41.065 -25.226  -39.097 1.00 94.87  ? 93   GLY   B C   1 
ATOM   5624 O  O   . GLY   B 2 92  ? -40.156 -24.433  -39.409 1.00 94.38  ? 93   GLY   B O   1 
ATOM   5625 N  N   . ILE   B 2 93  ? -40.955 -26.180  -38.162 1.00 91.37  ? 94   ILE   B N   1 
ATOM   5626 C  CA  . ILE   B 2 93  ? -39.724 -26.499  -37.371 1.00 87.08  ? 94   ILE   B CA  1 
ATOM   5627 C  C   . ILE   B 2 93  ? -39.553 -28.025  -37.343 1.00 79.93  ? 94   ILE   B C   1 
ATOM   5628 O  O   . ILE   B 2 93  ? -40.414 -28.698  -36.737 1.00 72.43  ? 94   ILE   B O   1 
ATOM   5629 C  CB  . ILE   B 2 93  ? -39.814 -25.918  -35.943 1.00 89.72  ? 94   ILE   B CB  1 
ATOM   5630 C  CG1 . ILE   B 2 93  ? -40.091 -24.411  -35.941 1.00 91.70  ? 94   ILE   B CG1 1 
ATOM   5631 C  CG2 . ILE   B 2 93  ? -38.563 -26.256  -35.145 1.00 87.72  ? 94   ILE   B CG2 1 
ATOM   5632 C  CD1 . ILE   B 2 93  ? -40.780 -23.916  -34.689 1.00 93.23  ? 94   ILE   B CD1 1 
ATOM   5633 N  N   . LEU   B 2 94  ? -38.494 -28.548  -37.976 1.00 75.98  ? 95   LEU   B N   1 
ATOM   5634 C  CA  . LEU   B 2 94  ? -38.194 -30.007  -38.038 1.00 75.49  ? 95   LEU   B CA  1 
ATOM   5635 C  C   . LEU   B 2 94  ? -37.196 -30.360  -36.929 1.00 73.65  ? 95   LEU   B C   1 
ATOM   5636 O  O   . LEU   B 2 94  ? -36.171 -29.659  -36.815 1.00 68.60  ? 95   LEU   B O   1 
ATOM   5637 C  CB  . LEU   B 2 94  ? -37.638 -30.352  -39.422 1.00 73.60  ? 95   LEU   B CB  1 
ATOM   5638 C  CG  . LEU   B 2 94  ? -37.546 -31.844  -39.744 1.00 74.06  ? 95   LEU   B CG  1 
ATOM   5639 C  CD1 . LEU   B 2 94  ? -38.930 -32.478  -39.848 1.00 72.67  ? 95   LEU   B CD1 1 
ATOM   5640 C  CD2 . LEU   B 2 94  ? -36.761 -32.063  -41.027 1.00 71.79  ? 95   LEU   B CD2 1 
ATOM   5641 N  N   . VAL   B 2 95  ? -37.486 -31.406  -36.149 1.00 72.08  ? 96   VAL   B N   1 
ATOM   5642 C  CA  . VAL   B 2 95  ? -36.797 -31.687  -34.853 1.00 73.88  ? 96   VAL   B CA  1 
ATOM   5643 C  C   . VAL   B 2 95  ? -36.230 -33.111  -34.848 1.00 70.73  ? 96   VAL   B C   1 
ATOM   5644 O  O   . VAL   B 2 95  ? -36.992 -34.065  -35.124 1.00 69.01  ? 96   VAL   B O   1 
ATOM   5645 C  CB  . VAL   B 2 95  ? -37.756 -31.467  -33.669 1.00 76.16  ? 96   VAL   B CB  1 
ATOM   5646 C  CG1 . VAL   B 2 95  ? -37.122 -31.858  -32.342 1.00 76.51  ? 96   VAL   B CG1 1 
ATOM   5647 C  CG2 . VAL   B 2 95  ? -38.259 -30.032  -33.623 1.00 77.14  ? 96   VAL   B CG2 1 
ATOM   5648 N  N   . ALA   B 2 96  ? -34.942 -33.231  -34.511 1.00 68.73  ? 97   ALA   B N   1 
ATOM   5649 C  CA  . ALA   B 2 96  ? -34.232 -34.500  -34.221 1.00 66.97  ? 97   ALA   B CA  1 
ATOM   5650 C  C   . ALA   B 2 96  ? -34.327 -34.804  -32.718 1.00 64.62  ? 97   ALA   B C   1 
ATOM   5651 O  O   . ALA   B 2 96  ? -33.615 -34.138  -31.932 1.00 60.41  ? 97   ALA   B O   1 
ATOM   5652 C  CB  . ALA   B 2 96  ? -32.798 -34.391  -34.677 1.00 67.14  ? 97   ALA   B CB  1 
ATOM   5653 N  N   . SER   B 2 97  ? -35.186 -35.760  -32.342 1.00 64.39  ? 98   SER   B N   1 
ATOM   5654 C  CA  . SER   B 2 97  ? -35.454 -36.181  -30.941 1.00 68.97  ? 98   SER   B CA  1 
ATOM   5655 C  C   . SER   B 2 97  ? -34.385 -37.171  -30.457 1.00 75.27  ? 98   SER   B C   1 
ATOM   5656 O  O   . SER   B 2 97  ? -33.690 -37.768  -31.305 1.00 78.63  ? 98   SER   B O   1 
ATOM   5657 C  CB  . SER   B 2 97  ? -36.821 -36.803  -30.825 1.00 70.55  ? 98   SER   B CB  1 
ATOM   5658 O  OG  . SER   B 2 97  ? -37.113 -37.138  -29.479 1.00 72.98  ? 98   SER   B OG  1 
ATOM   5659 N  N   . ASP   B 2 98  ? -34.286 -37.350  -29.137 1.00 77.80  ? 99   ASP   B N   1 
ATOM   5660 C  CA  . ASP   B 2 98  ? -33.573 -38.486  -28.489 1.00 73.00  ? 99   ASP   B CA  1 
ATOM   5661 C  C   . ASP   B 2 98  ? -34.434 -39.751  -28.596 1.00 76.09  ? 99   ASP   B C   1 
ATOM   5662 O  O   . ASP   B 2 98  ? -33.858 -40.856  -28.529 1.00 81.21  ? 99   ASP   B O   1 
ATOM   5663 C  CB  . ASP   B 2 98  ? -33.259 -38.192  -27.019 1.00 69.08  ? 99   ASP   B CB  1 
ATOM   5664 C  CG  . ASP   B 2 98  ? -32.138 -37.192  -26.821 1.00 65.52  ? 99   ASP   B CG  1 
ATOM   5665 O  OD1 . ASP   B 2 98  ? -31.126 -37.307  -27.534 1.00 67.24  ? 99   ASP   B OD1 1 
ATOM   5666 O  OD2 . ASP   B 2 98  ? -32.283 -36.306  -25.957 1.00 59.20  ? 99   ASP   B OD2 1 
ATOM   5667 N  N   . SER   B 2 99  ? -35.754 -39.591  -28.757 1.00 73.01  ? 100  SER   B N   1 
ATOM   5668 C  CA  . SER   B 2 99  ? -36.761 -40.686  -28.774 1.00 73.70  ? 100  SER   B CA  1 
ATOM   5669 C  C   . SER   B 2 99  ? -36.546 -41.611  -29.977 1.00 73.11  ? 100  SER   B C   1 
ATOM   5670 O  O   . SER   B 2 99  ? -37.116 -42.721  -29.966 1.00 75.48  ? 100  SER   B O   1 
ATOM   5671 C  CB  . SER   B 2 99  ? -38.163 -40.131  -28.771 1.00 77.13  ? 100  SER   B CB  1 
ATOM   5672 O  OG  . SER   B 2 99  ? -38.399 -39.321  -29.916 1.00 78.28  ? 100  SER   B OG  1 
ATOM   5673 N  N   . GLY   B 2 100 ? -35.766 -41.170  -30.970 1.00 73.42  ? 101  GLY   B N   1 
ATOM   5674 C  CA  . GLY   B 2 100 ? -35.617 -41.846  -32.273 1.00 78.57  ? 101  GLY   B CA  1 
ATOM   5675 C  C   . GLY   B 2 100 ? -36.654 -41.344  -33.263 1.00 79.69  ? 101  GLY   B C   1 
ATOM   5676 O  O   . GLY   B 2 100 ? -36.748 -41.899  -34.374 1.00 77.98  ? 101  GLY   B O   1 
ATOM   5677 N  N   . ALA   B 2 101 ? -37.406 -40.315  -32.869 1.00 83.78  ? 102  ALA   B N   1 
ATOM   5678 C  CA  . ALA   B 2 101 ? -38.459 -39.678  -33.685 1.00 83.99  ? 102  ALA   B CA  1 
ATOM   5679 C  C   . ALA   B 2 101 ? -37.888 -38.444  -34.386 1.00 84.81  ? 102  ALA   B C   1 
ATOM   5680 O  O   . ALA   B 2 101 ? -37.119 -37.686  -33.754 1.00 79.53  ? 102  ALA   B O   1 
ATOM   5681 C  CB  . ALA   B 2 101 ? -39.635 -39.313  -32.817 1.00 85.61  ? 102  ALA   B CB  1 
ATOM   5682 N  N   . VAL   B 2 102 ? -38.233 -38.288  -35.664 1.00 86.28  ? 103  VAL   B N   1 
ATOM   5683 C  CA  . VAL   B 2 102 ? -38.246 -36.984  -36.384 1.00 85.93  ? 103  VAL   B CA  1 
ATOM   5684 C  C   . VAL   B 2 102 ? -39.656 -36.412  -36.209 1.00 84.98  ? 103  VAL   B C   1 
ATOM   5685 O  O   . VAL   B 2 102 ? -40.618 -37.148  -36.503 1.00 85.09  ? 103  VAL   B O   1 
ATOM   5686 C  CB  . VAL   B 2 102 ? -37.877 -37.164  -37.867 1.00 87.30  ? 103  VAL   B CB  1 
ATOM   5687 C  CG1 . VAL   B 2 102 ? -37.976 -35.858  -38.641 1.00 89.93  ? 103  VAL   B CG1 1 
ATOM   5688 C  CG2 . VAL   B 2 102 ? -36.494 -37.778  -38.024 1.00 88.50  ? 103  VAL   B CG2 1 
ATOM   5689 N  N   . GLU   B 2 103 ? -39.786 -35.184  -35.704 1.00 87.64  ? 104  GLU   B N   1 
ATOM   5690 C  CA  . GLU   B 2 103 ? -41.115 -34.549  -35.489 1.00 93.20  ? 104  GLU   B CA  1 
ATOM   5691 C  C   . GLU   B 2 103 ? -41.138 -33.161  -36.137 1.00 89.80  ? 104  GLU   B C   1 
ATOM   5692 O  O   . GLU   B 2 103 ? -40.120 -32.433  -36.060 1.00 86.67  ? 104  GLU   B O   1 
ATOM   5693 C  CB  . GLU   B 2 103 ? -41.518 -34.531  -34.008 1.00 99.59  ? 104  GLU   B CB  1 
ATOM   5694 C  CG  . GLU   B 2 103 ? -40.426 -34.139  -33.025 1.00 101.51 ? 104  GLU   B CG  1 
ATOM   5695 C  CD  . GLU   B 2 103 ? -40.781 -34.405  -31.567 1.00 104.07 ? 104  GLU   B CD  1 
ATOM   5696 O  OE1 . GLU   B 2 103 ? -39.853 -34.621  -30.760 1.00 105.69 ? 104  GLU   B OE1 1 
ATOM   5697 O  OE2 . GLU   B 2 103 ? -41.986 -34.396  -31.238 1.00 108.78 ? 104  GLU   B OE2 1 
ATOM   5698 N  N   . LEU   B 2 104 ? -42.266 -32.845  -36.779 1.00 87.53  ? 105  LEU   B N   1 
ATOM   5699 C  CA  . LEU   B 2 104 ? -42.553 -31.534  -37.414 1.00 89.45  ? 105  LEU   B CA  1 
ATOM   5700 C  C   . LEU   B 2 104 ? -43.535 -30.766  -36.527 1.00 91.48  ? 105  LEU   B C   1 
ATOM   5701 O  O   . LEU   B 2 104 ? -44.668 -31.258  -36.326 1.00 87.84  ? 105  LEU   B O   1 
ATOM   5702 C  CB  . LEU   B 2 104 ? -43.132 -31.770  -38.812 1.00 91.38  ? 105  LEU   B CB  1 
ATOM   5703 C  CG  . LEU   B 2 104 ? -43.445 -30.519  -39.634 1.00 90.70  ? 105  LEU   B CG  1 
ATOM   5704 C  CD1 . LEU   B 2 104 ? -42.204 -29.657  -39.825 1.00 89.30  ? 105  LEU   B CD1 1 
ATOM   5705 C  CD2 . LEU   B 2 104 ? -44.044 -30.900  -40.980 1.00 89.01  ? 105  LEU   B CD2 1 
ATOM   5706 N  N   . TRP   B 2 105 ? -43.076 -29.634  -35.987 1.00 96.11  ? 106  TRP   B N   1 
ATOM   5707 C  CA  . TRP   B 2 105 ? -43.901 -28.572  -35.355 1.00 100.51 ? 106  TRP   B CA  1 
ATOM   5708 C  C   . TRP   B 2 105 ? -43.984 -27.395  -36.333 1.00 105.11 ? 106  TRP   B C   1 
ATOM   5709 O  O   . TRP   B 2 105 ? -42.948 -27.084  -36.958 1.00 101.90 ? 106  TRP   B O   1 
ATOM   5710 C  CB  . TRP   B 2 105 ? -43.294 -28.144  -34.010 1.00 103.26 ? 106  TRP   B CB  1 
ATOM   5711 C  CG  . TRP   B 2 105 ? -43.138 -29.255  -33.018 1.00 104.01 ? 106  TRP   B CG  1 
ATOM   5712 C  CD1 . TRP   B 2 105 ? -42.232 -30.274  -33.061 1.00 105.02 ? 106  TRP   B CD1 1 
ATOM   5713 C  CD2 . TRP   B 2 105 ? -43.906 -29.457  -31.819 1.00 106.40 ? 106  TRP   B CD2 1 
ATOM   5714 N  NE1 . TRP   B 2 105 ? -42.392 -31.100  -31.982 1.00 105.62 ? 106  TRP   B NE1 1 
ATOM   5715 C  CE2 . TRP   B 2 105 ? -43.410 -30.625  -31.201 1.00 105.96 ? 106  TRP   B CE2 1 
ATOM   5716 C  CE3 . TRP   B 2 105 ? -44.967 -28.775  -31.212 1.00 109.73 ? 106  TRP   B CE3 1 
ATOM   5717 C  CZ2 . TRP   B 2 105 ? -43.940 -31.120  -30.009 1.00 108.87 ? 106  TRP   B CZ2 1 
ATOM   5718 C  CZ3 . TRP   B 2 105 ? -45.490 -29.264  -30.034 1.00 109.80 ? 106  TRP   B CZ3 1 
ATOM   5719 C  CH2 . TRP   B 2 105 ? -44.981 -30.421  -29.442 1.00 108.07 ? 106  TRP   B CH2 1 
ATOM   5720 N  N   . GLU   B 2 106 ? -45.161 -26.777  -36.475 1.00 108.78 ? 107  GLU   B N   1 
ATOM   5721 C  CA  . GLU   B 2 106 ? -45.334 -25.509  -37.240 1.00 109.51 ? 107  GLU   B CA  1 
ATOM   5722 C  C   . GLU   B 2 106 ? -46.142 -24.515  -36.400 1.00 105.71 ? 107  GLU   B C   1 
ATOM   5723 O  O   . GLU   B 2 106 ? -47.071 -24.952  -35.692 1.00 111.94 ? 107  GLU   B O   1 
ATOM   5724 C  CB  . GLU   B 2 106 ? -45.976 -25.754  -38.610 1.00 110.12 ? 107  GLU   B CB  1 
ATOM   5725 C  CG  . GLU   B 2 106 ? -47.292 -26.511  -38.566 1.00 110.02 ? 107  GLU   B CG  1 
ATOM   5726 C  CD  . GLU   B 2 106 ? -47.811 -26.934  -39.930 1.00 111.28 ? 107  GLU   B CD  1 
ATOM   5727 O  OE1 . GLU   B 2 106 ? -48.724 -27.782  -39.973 1.00 111.19 ? 107  GLU   B OE1 1 
ATOM   5728 O  OE2 . GLU   B 2 106 ? -47.300 -26.418  -40.947 1.00 108.72 ? 107  GLU   B OE2 1 
ATOM   5729 N  N   . LEU   B 2 107 ? -45.776 -23.232  -36.474 1.00 100.68 ? 108  LEU   B N   1 
ATOM   5730 C  CA  . LEU   B 2 107 ? -46.477 -22.107  -35.799 1.00 100.24 ? 108  LEU   B CA  1 
ATOM   5731 C  C   . LEU   B 2 107 ? -47.922 -22.037  -36.308 1.00 102.55 ? 108  LEU   B C   1 
ATOM   5732 O  O   . LEU   B 2 107 ? -48.137 -22.324  -37.503 1.00 104.13 ? 108  LEU   B O   1 
ATOM   5733 C  CB  . LEU   B 2 107 ? -45.740 -20.801  -36.109 1.00 95.28  ? 108  LEU   B CB  1 
ATOM   5734 C  CG  . LEU   B 2 107 ? -44.327 -20.683  -35.542 1.00 94.64  ? 108  LEU   B CG  1 
ATOM   5735 C  CD1 . LEU   B 2 107 ? -43.438 -19.865  -36.467 1.00 93.70  ? 108  LEU   B CD1 1 
ATOM   5736 C  CD2 . LEU   B 2 107 ? -44.355 -20.078  -34.148 1.00 95.20  ? 108  LEU   B CD2 1 
ATOM   5737 N  N   . ASP   B 2 108 ? -48.866 -21.662  -35.438 1.00 105.10 ? 109  ASP   B N   1 
ATOM   5738 C  CA  . ASP   B 2 108 ? -50.261 -21.313  -35.825 1.00 107.07 ? 109  ASP   B CA  1 
ATOM   5739 C  C   . ASP   B 2 108 ? -50.225 -19.985  -36.597 1.00 112.79 ? 109  ASP   B C   1 
ATOM   5740 O  O   . ASP   B 2 108 ? -49.130 -19.385  -36.700 1.00 112.33 ? 109  ASP   B O   1 
ATOM   5741 C  CB  . ASP   B 2 108 ? -51.196 -21.278  -34.610 1.00 102.87 ? 109  ASP   B CB  1 
ATOM   5742 C  CG  . ASP   B 2 108 ? -50.915 -20.169  -33.606 1.00 98.62  ? 109  ASP   B CG  1 
ATOM   5743 O  OD1 . ASP   B 2 108 ? -49.857 -19.518  -33.719 1.00 89.79  ? 109  ASP   B OD1 1 
ATOM   5744 O  OD2 . ASP   B 2 108 ? -51.757 -19.970  -32.710 1.00 99.79  ? 109  ASP   B OD2 1 
ATOM   5745 N  N   . GLU   B 2 109 ? -51.379 -19.541  -37.108 1.00 116.65 ? 110  GLU   B N   1 
ATOM   5746 C  CA  . GLU   B 2 109 ? -51.509 -18.353  -38.000 1.00 115.76 ? 110  GLU   B CA  1 
ATOM   5747 C  C   . GLU   B 2 109 ? -51.021 -17.094  -37.268 1.00 112.07 ? 110  GLU   B C   1 
ATOM   5748 O  O   . GLU   B 2 109 ? -50.310 -16.284  -37.900 1.00 104.19 ? 110  GLU   B O   1 
ATOM   5749 C  CB  . GLU   B 2 109 ? -52.957 -18.208  -38.479 1.00 116.25 ? 110  GLU   B CB  1 
ATOM   5750 C  CG  . GLU   B 2 109 ? -53.433 -19.373  -39.335 1.00 115.77 ? 110  GLU   B CG  1 
ATOM   5751 C  CD  . GLU   B 2 109 ? -54.908 -19.352  -39.699 1.00 113.98 ? 110  GLU   B CD  1 
ATOM   5752 O  OE1 . GLU   B 2 109 ? -55.564 -18.319  -39.455 1.00 115.18 ? 110  GLU   B OE1 1 
ATOM   5753 O  OE2 . GLU   B 2 109 ? -55.398 -20.372  -40.223 1.00 106.72 ? 110  GLU   B OE2 1 
ATOM   5754 N  N   . ASN   B 2 110 ? -51.372 -16.952  -35.984 1.00 110.76 ? 111  ASN   B N   1 
ATOM   5755 C  CA  . ASN   B 2 110 ? -50.996 -15.802  -35.115 1.00 111.64 ? 111  ASN   B CA  1 
ATOM   5756 C  C   . ASN   B 2 110 ? -49.493 -15.835  -34.810 1.00 108.96 ? 111  ASN   B C   1 
ATOM   5757 O  O   . ASN   B 2 110 ? -48.933 -14.752  -34.540 1.00 107.83 ? 111  ASN   B O   1 
ATOM   5758 C  CB  . ASN   B 2 110 ? -51.781 -15.798  -33.800 1.00 118.02 ? 111  ASN   B CB  1 
ATOM   5759 C  CG  . ASN   B 2 110 ? -53.261 -15.533  -33.985 1.00 122.42 ? 111  ASN   B CG  1 
ATOM   5760 O  OD1 . ASN   B 2 110 ? -54.093 -16.359  -33.617 1.00 127.45 ? 111  ASN   B OD1 1 
ATOM   5761 N  ND2 . ASN   B 2 110 ? -53.598 -14.387  -34.555 1.00 123.20 ? 111  ASN   B ND2 1 
ATOM   5762 N  N   . GLU   B 2 111 ? -48.885 -17.030  -34.836 1.00 106.55 ? 112  GLU   B N   1 
ATOM   5763 C  CA  . GLU   B 2 111 ? -47.473 -17.303  -34.444 1.00 101.50 ? 112  GLU   B CA  1 
ATOM   5764 C  C   . GLU   B 2 111 ? -47.318 -17.056  -32.937 1.00 100.17 ? 112  GLU   B C   1 
ATOM   5765 O  O   . GLU   B 2 111 ? -46.332 -16.403  -32.537 1.00 96.83  ? 112  GLU   B O   1 
ATOM   5766 C  CB  . GLU   B 2 111 ? -46.493 -16.453  -35.258 1.00 99.12  ? 112  GLU   B CB  1 
ATOM   5767 C  CG  . GLU   B 2 111 ? -46.578 -16.684  -36.757 1.00 96.47  ? 112  GLU   B CG  1 
ATOM   5768 C  CD  . GLU   B 2 111 ? -45.445 -16.057  -37.553 1.00 95.55  ? 112  GLU   B CD  1 
ATOM   5769 O  OE1 . GLU   B 2 111 ? -44.746 -15.179  -37.001 1.00 91.50  ? 112  GLU   B OE1 1 
ATOM   5770 O  OE2 . GLU   B 2 111 ? -45.252 -16.455  -38.722 1.00 90.00  ? 112  GLU   B OE2 1 
ATOM   5771 N  N   . THR   B 2 112 ? -48.273 -17.550  -32.143 1.00 103.51 ? 113  THR   B N   1 
ATOM   5772 C  CA  . THR   B 2 112 ? -48.285 -17.471  -30.656 1.00 105.98 ? 113  THR   B CA  1 
ATOM   5773 C  C   . THR   B 2 112 ? -48.193 -18.882  -30.060 1.00 104.91 ? 113  THR   B C   1 
ATOM   5774 O  O   . THR   B 2 112 ? -47.584 -19.010  -28.981 1.00 107.40 ? 113  THR   B O   1 
ATOM   5775 C  CB  . THR   B 2 112 ? -49.512 -16.698  -30.153 1.00 106.49 ? 113  THR   B CB  1 
ATOM   5776 O  OG1 . THR   B 2 112 ? -50.685 -17.243  -30.760 1.00 103.79 ? 113  THR   B OG1 1 
ATOM   5777 C  CG2 . THR   B 2 112 ? -49.419 -15.216  -30.447 1.00 104.19 ? 113  THR   B CG2 1 
ATOM   5778 N  N   . LEU   B 2 113 ? -48.778 -19.887  -30.725 1.00 103.27 ? 114  LEU   B N   1 
ATOM   5779 C  CA  . LEU   B 2 113 ? -48.652 -21.329  -30.369 1.00 105.94 ? 114  LEU   B CA  1 
ATOM   5780 C  C   . LEU   B 2 113 ? -47.686 -22.028  -31.338 1.00 104.20 ? 114  LEU   B C   1 
ATOM   5781 O  O   . LEU   B 2 113 ? -47.489 -21.519  -32.463 1.00 106.04 ? 114  LEU   B O   1 
ATOM   5782 C  CB  . LEU   B 2 113 ? -50.035 -21.991  -30.413 1.00 109.13 ? 114  LEU   B CB  1 
ATOM   5783 C  CG  . LEU   B 2 113 ? -51.086 -21.443  -29.445 1.00 112.05 ? 114  LEU   B CG  1 
ATOM   5784 C  CD1 . LEU   B 2 113 ? -52.318 -22.339  -29.428 1.00 109.02 ? 114  LEU   B CD1 1 
ATOM   5785 C  CD2 . LEU   B 2 113 ? -50.525 -21.287  -28.037 1.00 110.83 ? 114  LEU   B CD2 1 
ATOM   5786 N  N   . ILE   B 2 114 ? -47.100 -23.148  -30.898 1.00 97.17  ? 115  ILE   B N   1 
ATOM   5787 C  CA  . ILE   B 2 114 ? -46.276 -24.083  -31.724 1.00 91.06  ? 115  ILE   B CA  1 
ATOM   5788 C  C   . ILE   B 2 114 ? -46.882 -25.483  -31.569 1.00 89.74  ? 115  ILE   B C   1 
ATOM   5789 O  O   . ILE   B 2 114 ? -46.830 -26.022  -30.449 1.00 90.76  ? 115  ILE   B O   1 
ATOM   5790 C  CB  . ILE   B 2 114 ? -44.789 -24.036  -31.310 1.00 87.25  ? 115  ILE   B CB  1 
ATOM   5791 C  CG1 . ILE   B 2 114 ? -44.222 -22.613  -31.374 1.00 86.09  ? 115  ILE   B CG1 1 
ATOM   5792 C  CG2 . ILE   B 2 114 ? -43.969 -25.003  -32.150 1.00 88.10  ? 115  ILE   B CG2 1 
ATOM   5793 C  CD1 . ILE   B 2 114 ? -42.842 -22.459  -30.772 1.00 84.68  ? 115  ILE   B CD1 1 
ATOM   5794 N  N   . VAL   B 2 115 ? -47.456 -26.036  -32.642 1.00 89.75  ? 116  VAL   B N   1 
ATOM   5795 C  CA  . VAL   B 2 115 ? -48.277 -27.284  -32.605 1.00 91.82  ? 116  VAL   B CA  1 
ATOM   5796 C  C   . VAL   B 2 115 ? -47.540 -28.391  -33.366 1.00 91.61  ? 116  VAL   B C   1 
ATOM   5797 O  O   . VAL   B 2 115 ? -47.030 -28.116  -34.471 1.00 91.92  ? 116  VAL   B O   1 
ATOM   5798 C  CB  . VAL   B 2 115 ? -49.690 -27.053  -33.182 1.00 93.77  ? 116  VAL   B CB  1 
ATOM   5799 C  CG1 . VAL   B 2 115 ? -50.635 -28.197  -32.837 1.00 92.93  ? 116  VAL   B CG1 1 
ATOM   5800 C  CG2 . VAL   B 2 115 ? -50.283 -25.725  -32.733 1.00 93.45  ? 116  VAL   B CG2 1 
ATOM   5801 N  N   . SER   B 2 116 ? -47.494 -29.595  -32.787 1.00 90.13  ? 117  SER   B N   1 
ATOM   5802 C  CA  . SER   B 2 116 ? -46.983 -30.833  -33.433 1.00 92.61  ? 117  SER   B CA  1 
ATOM   5803 C  C   . SER   B 2 116 ? -47.938 -31.239  -34.559 1.00 93.34  ? 117  SER   B C   1 
ATOM   5804 O  O   . SER   B 2 116 ? -49.136 -31.420  -34.267 1.00 91.85  ? 117  SER   B O   1 
ATOM   5805 C  CB  . SER   B 2 116 ? -46.812 -31.952  -32.427 1.00 92.15  ? 117  SER   B CB  1 
ATOM   5806 O  OG  . SER   B 2 116 ? -46.961 -33.226  -33.041 1.00 91.41  ? 117  SER   B OG  1 
ATOM   5807 N  N   . LYS   B 2 117 ? -47.431 -31.368  -35.789 1.00 96.14  ? 118  LYS   B N   1 
ATOM   5808 C  CA  . LYS   B 2 117 ? -48.213 -31.882  -36.945 1.00 102.98 ? 118  LYS   B CA  1 
ATOM   5809 C  C   . LYS   B 2 117 ? -48.005 -33.397  -37.055 1.00 99.37  ? 118  LYS   B C   1 
ATOM   5810 O  O   . LYS   B 2 117 ? -49.012 -34.108  -37.251 1.00 97.14  ? 118  LYS   B O   1 
ATOM   5811 C  CB  . LYS   B 2 117 ? -47.842 -31.165  -38.248 1.00 110.58 ? 118  LYS   B CB  1 
ATOM   5812 C  CG  . LYS   B 2 117 ? -48.660 -31.578  -39.469 1.00 117.49 ? 118  LYS   B CG  1 
ATOM   5813 C  CD  . LYS   B 2 117 ? -50.172 -31.439  -39.303 1.00 119.94 ? 118  LYS   B CD  1 
ATOM   5814 C  CE  . LYS   B 2 117 ? -50.969 -32.185  -40.354 1.00 118.65 ? 118  LYS   B CE  1 
ATOM   5815 N  NZ  . LYS   B 2 117 ? -50.780 -31.609  -41.706 1.00 118.93 ? 118  LYS   B NZ  1 
ATOM   5816 N  N   . PHE   B 2 118 ? -46.757 -33.872  -36.942 1.00 99.86  ? 119  PHE   B N   1 
ATOM   5817 C  CA  . PHE   B 2 118 ? -46.420 -35.323  -36.909 1.00 95.79  ? 119  PHE   B CA  1 
ATOM   5818 C  C   . PHE   B 2 118 ? -45.209 -35.587  -36.006 1.00 90.00  ? 119  PHE   B C   1 
ATOM   5819 O  O   . PHE   B 2 118 ? -44.282 -34.752  -35.935 1.00 83.61  ? 119  PHE   B O   1 
ATOM   5820 C  CB  . PHE   B 2 118 ? -46.204 -35.883  -38.319 1.00 94.85  ? 119  PHE   B CB  1 
ATOM   5821 C  CG  . PHE   B 2 118 ? -44.865 -35.598  -38.953 1.00 94.91  ? 119  PHE   B CG  1 
ATOM   5822 C  CD1 . PHE   B 2 118 ? -43.736 -36.315  -38.589 1.00 94.88  ? 119  PHE   B CD1 1 
ATOM   5823 C  CD2 . PHE   B 2 118 ? -44.738 -34.637  -39.945 1.00 96.81  ? 119  PHE   B CD2 1 
ATOM   5824 C  CE1 . PHE   B 2 118 ? -42.508 -36.057  -39.179 1.00 94.79  ? 119  PHE   B CE1 1 
ATOM   5825 C  CE2 . PHE   B 2 118 ? -43.511 -34.386  -40.541 1.00 95.81  ? 119  PHE   B CE2 1 
ATOM   5826 C  CZ  . PHE   B 2 118 ? -42.396 -35.092  -40.153 1.00 95.80  ? 119  PHE   B CZ  1 
ATOM   5827 N  N   . CYS   B 2 119 ? -45.249 -36.744  -35.339 1.00 89.67  ? 120  CYS   B N   1 
ATOM   5828 C  CA  . CYS   B 2 119 ? -44.164 -37.350  -34.523 1.00 89.55  ? 120  CYS   B CA  1 
ATOM   5829 C  C   . CYS   B 2 119 ? -44.039 -38.823  -34.935 1.00 86.54  ? 120  CYS   B C   1 
ATOM   5830 O  O   . CYS   B 2 119 ? -44.952 -39.605  -34.599 1.00 88.12  ? 120  CYS   B O   1 
ATOM   5831 C  CB  . CYS   B 2 119 ? -44.473 -37.207  -33.035 1.00 90.24  ? 120  CYS   B CB  1 
ATOM   5832 S  SG  . CYS   B 2 119 ? -43.082 -37.596  -31.940 1.00 87.02  ? 120  CYS   B SG  1 
ATOM   5833 N  N   . LYS   B 2 120 ? -42.985 -39.173  -35.682 1.00 85.03  ? 121  LYS   B N   1 
ATOM   5834 C  CA  . LYS   B 2 120 ? -42.795 -40.526  -36.280 1.00 88.45  ? 121  LYS   B CA  1 
ATOM   5835 C  C   . LYS   B 2 120 ? -41.521 -41.180  -35.723 1.00 84.23  ? 121  LYS   B C   1 
ATOM   5836 O  O   . LYS   B 2 120 ? -40.409 -40.699  -36.035 1.00 78.80  ? 121  LYS   B O   1 
ATOM   5837 C  CB  . LYS   B 2 120 ? -42.763 -40.432  -37.809 1.00 90.61  ? 121  LYS   B CB  1 
ATOM   5838 C  CG  . LYS   B 2 120 ? -44.063 -39.975  -38.460 1.00 93.47  ? 121  LYS   B CG  1 
ATOM   5839 C  CD  . LYS   B 2 120 ? -45.291 -40.739  -38.005 1.00 95.15  ? 121  LYS   B CD  1 
ATOM   5840 C  CE  . LYS   B 2 120 ? -46.515 -40.449  -38.845 1.00 96.69  ? 121  LYS   B CE  1 
ATOM   5841 N  NZ  . LYS   B 2 120 ? -47.739 -41.017  -38.233 1.00 96.45  ? 121  LYS   B NZ  1 
ATOM   5842 N  N   . TYR   B 2 121 ? -41.694 -42.249  -34.940 1.00 80.38  ? 122  TYR   B N   1 
ATOM   5843 C  CA  . TYR   B 2 121 ? -40.612 -43.026  -34.282 1.00 79.41  ? 122  TYR   B CA  1 
ATOM   5844 C  C   . TYR   B 2 121 ? -40.060 -44.040  -35.292 1.00 76.25  ? 122  TYR   B C   1 
ATOM   5845 O  O   . TYR   B 2 121 ? -40.491 -45.208  -35.271 1.00 73.26  ? 122  TYR   B O   1 
ATOM   5846 C  CB  . TYR   B 2 121 ? -41.143 -43.683  -33.003 1.00 79.71  ? 122  TYR   B CB  1 
ATOM   5847 C  CG  . TYR   B 2 121 ? -41.758 -42.726  -32.013 1.00 81.68  ? 122  TYR   B CG  1 
ATOM   5848 C  CD1 . TYR   B 2 121 ? -40.966 -41.985  -31.148 1.00 82.84  ? 122  TYR   B CD1 1 
ATOM   5849 C  CD2 . TYR   B 2 121 ? -43.133 -42.559  -31.931 1.00 83.64  ? 122  TYR   B CD2 1 
ATOM   5850 C  CE1 . TYR   B 2 121 ? -41.519 -41.101  -30.234 1.00 82.66  ? 122  TYR   B CE1 1 
ATOM   5851 C  CE2 . TYR   B 2 121 ? -43.703 -41.681  -31.021 1.00 85.64  ? 122  TYR   B CE2 1 
ATOM   5852 C  CZ  . TYR   B 2 121 ? -42.893 -40.948  -30.169 1.00 85.19  ? 122  TYR   B CZ  1 
ATOM   5853 O  OH  . TYR   B 2 121 ? -43.445 -40.081  -29.270 1.00 80.50  ? 122  TYR   B OH  1 
ATOM   5854 N  N   . GLU   B 2 122 ? -39.143 -43.589  -36.156 1.00 76.76  ? 123  GLU   B N   1 
ATOM   5855 C  CA  . GLU   B 2 122 ? -38.629 -44.354  -37.328 1.00 79.70  ? 123  GLU   B CA  1 
ATOM   5856 C  C   . GLU   B 2 122 ? -37.172 -44.793  -37.111 1.00 80.73  ? 123  GLU   B C   1 
ATOM   5857 O  O   . GLU   B 2 122 ? -36.804 -45.857  -37.659 1.00 77.54  ? 123  GLU   B O   1 
ATOM   5858 C  CB  . GLU   B 2 122 ? -38.773 -43.513  -38.599 1.00 82.44  ? 123  GLU   B CB  1 
ATOM   5859 C  CG  . GLU   B 2 122 ? -40.157 -43.599  -39.215 1.00 84.89  ? 123  GLU   B CG  1 
ATOM   5860 C  CD  . GLU   B 2 122 ? -40.542 -44.996  -39.675 1.00 87.94  ? 123  GLU   B CD  1 
ATOM   5861 O  OE1 . GLU   B 2 122 ? -39.818 -45.557  -40.522 1.00 92.05  ? 123  GLU   B OE1 1 
ATOM   5862 O  OE2 . GLU   B 2 122 ? -41.549 -45.529  -39.167 1.00 87.64  ? 123  GLU   B OE2 1 
ATOM   5863 N  N   . HIS   B 2 123 ? -36.376 -44.003  -36.376 1.00 79.15  ? 124  HIS   B N   1 
ATOM   5864 C  CA  . HIS   B 2 123 ? -34.968 -44.313  -35.997 1.00 76.18  ? 124  HIS   B CA  1 
ATOM   5865 C  C   . HIS   B 2 123 ? -34.950 -45.148  -34.708 1.00 77.70  ? 124  HIS   B C   1 
ATOM   5866 O  O   . HIS   B 2 123 ? -35.840 -44.946  -33.863 1.00 83.15  ? 124  HIS   B O   1 
ATOM   5867 C  CB  . HIS   B 2 123 ? -34.146 -43.025  -35.850 1.00 75.27  ? 124  HIS   B CB  1 
ATOM   5868 C  CG  . HIS   B 2 123 ? -33.607 -42.480  -37.131 1.00 74.49  ? 124  HIS   B CG  1 
ATOM   5869 N  ND1 . HIS   B 2 123 ? -32.691 -43.171  -37.899 1.00 74.86  ? 124  HIS   B ND1 1 
ATOM   5870 C  CD2 . HIS   B 2 123 ? -33.808 -41.299  -37.754 1.00 73.84  ? 124  HIS   B CD2 1 
ATOM   5871 C  CE1 . HIS   B 2 123 ? -32.369 -42.450  -38.953 1.00 73.25  ? 124  HIS   B CE1 1 
ATOM   5872 N  NE2 . HIS   B 2 123 ? -33.038 -41.296  -38.885 1.00 75.09  ? 124  HIS   B NE2 1 
ATOM   5873 N  N   . ASP   B 2 124 ? -33.963 -46.040  -34.566 1.00 76.13  ? 125  ASP   B N   1 
ATOM   5874 C  CA  . ASP   B 2 124 ? -33.867 -47.042  -33.467 1.00 74.12  ? 125  ASP   B CA  1 
ATOM   5875 C  C   . ASP   B 2 124 ? -32.984 -46.509  -32.327 1.00 70.02  ? 125  ASP   B C   1 
ATOM   5876 O  O   . ASP   B 2 124 ? -32.936 -47.163  -31.270 1.00 70.86  ? 125  ASP   B O   1 
ATOM   5877 C  CB  . ASP   B 2 124 ? -33.352 -48.381  -34.005 1.00 76.82  ? 125  ASP   B CB  1 
ATOM   5878 C  CG  . ASP   B 2 124 ? -34.434 -49.273  -34.596 1.00 81.41  ? 125  ASP   B CG  1 
ATOM   5879 O  OD1 . ASP   B 2 124 ? -35.551 -49.286  -34.045 1.00 84.54  ? 125  ASP   B OD1 1 
ATOM   5880 O  OD2 . ASP   B 2 124 ? -34.147 -49.959  -35.596 1.00 86.59  ? 125  ASP   B OD2 1 
ATOM   5881 N  N   . ASP   B 2 125 ? -32.309 -45.377  -32.535 1.00 65.51  ? 126  ASP   B N   1 
ATOM   5882 C  CA  . ASP   B 2 125 ? -31.489 -44.671  -31.513 1.00 65.39  ? 126  ASP   B CA  1 
ATOM   5883 C  C   . ASP   B 2 125 ? -31.735 -43.167  -31.688 1.00 66.91  ? 126  ASP   B C   1 
ATOM   5884 O  O   . ASP   B 2 125 ? -32.460 -42.798  -32.631 1.00 68.65  ? 126  ASP   B O   1 
ATOM   5885 C  CB  . ASP   B 2 125 ? -30.006 -45.039  -31.657 1.00 66.38  ? 126  ASP   B CB  1 
ATOM   5886 C  CG  . ASP   B 2 125 ? -29.149 -44.883  -30.405 1.00 63.99  ? 126  ASP   B CG  1 
ATOM   5887 O  OD1 . ASP   B 2 125 ? -29.385 -43.929  -29.634 1.00 59.28  ? 126  ASP   B OD1 1 
ATOM   5888 O  OD2 . ASP   B 2 125 ? -28.228 -45.713  -30.223 1.00 61.82  ? 126  ASP   B OD2 1 
ATOM   5889 N  N   . ILE   B 2 126 ? -31.146 -42.339  -30.822 1.00 66.24  ? 127  ILE   B N   1 
ATOM   5890 C  CA  . ILE   B 2 126 ? -31.190 -40.849  -30.900 1.00 65.03  ? 127  ILE   B CA  1 
ATOM   5891 C  C   . ILE   B 2 126 ? -31.048 -40.426  -32.367 1.00 67.75  ? 127  ILE   B C   1 
ATOM   5892 O  O   . ILE   B 2 126 ? -30.173 -40.980  -33.062 1.00 64.50  ? 127  ILE   B O   1 
ATOM   5893 C  CB  . ILE   B 2 126 ? -30.084 -40.213  -30.029 1.00 66.11  ? 127  ILE   B CB  1 
ATOM   5894 C  CG1 . ILE   B 2 126 ? -30.263 -40.536  -28.542 1.00 65.49  ? 127  ILE   B CG1 1 
ATOM   5895 C  CG2 . ILE   B 2 126 ? -30.003 -38.711  -30.273 1.00 66.34  ? 127  ILE   B CG2 1 
ATOM   5896 C  CD1 . ILE   B 2 126 ? -29.046 -40.247  -27.692 1.00 62.75  ? 127  ILE   B CD1 1 
ATOM   5897 N  N   . VAL   B 2 127 ? -31.889 -39.484  -32.807 1.00 72.00  ? 128  VAL   B N   1 
ATOM   5898 C  CA  . VAL   B 2 127 ? -31.739 -38.733  -34.089 1.00 68.53  ? 128  VAL   B CA  1 
ATOM   5899 C  C   . VAL   B 2 127 ? -30.775 -37.581  -33.796 1.00 65.14  ? 128  VAL   B C   1 
ATOM   5900 O  O   . VAL   B 2 127 ? -31.102 -36.782  -32.912 1.00 60.08  ? 128  VAL   B O   1 
ATOM   5901 C  CB  . VAL   B 2 127 ? -33.091 -38.219  -34.625 1.00 70.67  ? 128  VAL   B CB  1 
ATOM   5902 C  CG1 . VAL   B 2 127 ? -32.947 -37.594  -36.006 1.00 70.67  ? 128  VAL   B CG1 1 
ATOM   5903 C  CG2 . VAL   B 2 127 ? -34.156 -39.309  -34.645 1.00 71.12  ? 128  VAL   B CG2 1 
ATOM   5904 N  N   . SER   B 2 128 ? -29.630 -37.529  -34.484 1.00 66.31  ? 129  SER   B N   1 
ATOM   5905 C  CA  . SER   B 2 128 ? -28.467 -36.667  -34.135 1.00 69.28  ? 129  SER   B CA  1 
ATOM   5906 C  C   . SER   B 2 128 ? -28.383 -35.447  -35.060 1.00 69.85  ? 129  SER   B C   1 
ATOM   5907 O  O   . SER   B 2 128 ? -27.811 -34.422  -34.634 1.00 70.23  ? 129  SER   B O   1 
ATOM   5908 C  CB  . SER   B 2 128 ? -27.184 -37.458  -34.180 1.00 68.74  ? 129  SER   B CB  1 
ATOM   5909 O  OG  . SER   B 2 128 ? -26.925 -37.916  -35.496 1.00 73.03  ? 129  SER   B OG  1 
ATOM   5910 N  N   . THR   B 2 129 ? -28.892 -35.566  -36.289 1.00 69.89  ? 130  THR   B N   1 
ATOM   5911 C  CA  . THR   B 2 129 ? -28.740 -34.546  -37.358 1.00 69.41  ? 130  THR   B CA  1 
ATOM   5912 C  C   . THR   B 2 129 ? -29.970 -34.577  -38.272 1.00 71.94  ? 130  THR   B C   1 
ATOM   5913 O  O   . THR   B 2 129 ? -30.510 -35.679  -38.514 1.00 69.27  ? 130  THR   B O   1 
ATOM   5914 C  CB  . THR   B 2 129 ? -27.426 -34.770  -38.115 1.00 66.44  ? 130  THR   B CB  1 
ATOM   5915 O  OG1 . THR   B 2 129 ? -27.260 -33.718  -39.066 1.00 61.97  ? 130  THR   B OG1 1 
ATOM   5916 C  CG2 . THR   B 2 129 ? -27.374 -36.116  -38.803 1.00 65.72  ? 130  THR   B CG2 1 
ATOM   5917 N  N   . VAL   B 2 130 ? -30.399 -33.405  -38.745 1.00 75.23  ? 131  VAL   B N   1 
ATOM   5918 C  CA  . VAL   B 2 130 ? -31.539 -33.263  -39.698 1.00 76.60  ? 131  VAL   B CA  1 
ATOM   5919 C  C   . VAL   B 2 130 ? -31.294 -32.022  -40.564 1.00 74.65  ? 131  VAL   B C   1 
ATOM   5920 O  O   . VAL   B 2 130 ? -30.726 -31.036  -40.050 1.00 73.79  ? 131  VAL   B O   1 
ATOM   5921 C  CB  . VAL   B 2 130 ? -32.887 -33.223  -38.951 1.00 77.74  ? 131  VAL   B CB  1 
ATOM   5922 C  CG1 . VAL   B 2 130 ? -33.174 -31.864  -38.330 1.00 78.47  ? 131  VAL   B CG1 1 
ATOM   5923 C  CG2 . VAL   B 2 130 ? -34.036 -33.664  -39.843 1.00 80.09  ? 131  VAL   B CG2 1 
ATOM   5924 N  N   . SER   B 2 131 ? -31.674 -32.100  -41.842 1.00 76.27  ? 132  SER   B N   1 
ATOM   5925 C  CA  . SER   B 2 131 ? -31.461 -31.045  -42.867 1.00 78.37  ? 132  SER   B CA  1 
ATOM   5926 C  C   . SER   B 2 131 ? -32.630 -31.049  -43.860 1.00 83.34  ? 132  SER   B C   1 
ATOM   5927 O  O   . SER   B 2 131 ? -33.012 -32.154  -44.309 1.00 84.18  ? 132  SER   B O   1 
ATOM   5928 C  CB  . SER   B 2 131 ? -30.143 -31.252  -43.563 1.00 74.43  ? 132  SER   B CB  1 
ATOM   5929 O  OG  . SER   B 2 131 ? -29.675 -30.047  -44.146 1.00 69.14  ? 132  SER   B OG  1 
ATOM   5930 N  N   . VAL   B 2 132 ? -33.187 -29.869  -44.164 1.00 85.50  ? 133  VAL   B N   1 
ATOM   5931 C  CA  . VAL   B 2 132 ? -34.244 -29.685  -45.208 1.00 89.05  ? 133  VAL   B CA  1 
ATOM   5932 C  C   . VAL   B 2 132 ? -33.556 -29.579  -46.573 1.00 86.24  ? 133  VAL   B C   1 
ATOM   5933 O  O   . VAL   B 2 132 ? -32.574 -28.816  -46.685 1.00 77.13  ? 133  VAL   B O   1 
ATOM   5934 C  CB  . VAL   B 2 132 ? -35.157 -28.468  -44.946 1.00 93.07  ? 133  VAL   B CB  1 
ATOM   5935 C  CG1 . VAL   B 2 132 ? -36.037 -28.682  -43.724 1.00 95.74  ? 133  VAL   B CG1 1 
ATOM   5936 C  CG2 . VAL   B 2 132 ? -34.389 -27.155  -44.838 1.00 92.10  ? 133  VAL   B CG2 1 
ATOM   5937 N  N   . LEU   B 2 133 ? -34.062 -30.320  -47.563 1.00 87.87  ? 134  LEU   B N   1 
ATOM   5938 C  CA  . LEU   B 2 133 ? -33.519 -30.357  -48.949 1.00 91.56  ? 134  LEU   B CA  1 
ATOM   5939 C  C   . LEU   B 2 133 ? -34.006 -29.125  -49.730 1.00 91.38  ? 134  LEU   B C   1 
ATOM   5940 O  O   . LEU   B 2 133 ? -34.960 -28.464  -49.268 1.00 92.31  ? 134  LEU   B O   1 
ATOM   5941 C  CB  . LEU   B 2 133 ? -33.939 -31.676  -49.606 1.00 91.24  ? 134  LEU   B CB  1 
ATOM   5942 C  CG  . LEU   B 2 133 ? -33.249 -32.923  -49.050 1.00 88.99  ? 134  LEU   B CG  1 
ATOM   5943 C  CD1 . LEU   B 2 133 ? -34.096 -34.168  -49.260 1.00 86.98  ? 134  LEU   B CD1 1 
ATOM   5944 C  CD2 . LEU   B 2 133 ? -31.875 -33.106  -49.674 1.00 90.44  ? 134  LEU   B CD2 1 
ATOM   5945 N  N   . SER   B 2 134 ? -33.356 -28.835  -50.864 1.00 92.14  ? 135  SER   B N   1 
ATOM   5946 C  CA  . SER   B 2 134 ? -33.493 -27.591  -51.673 1.00 93.24  ? 135  SER   B CA  1 
ATOM   5947 C  C   . SER   B 2 134 ? -34.968 -27.237  -51.921 1.00 95.45  ? 135  SER   B C   1 
ATOM   5948 O  O   . SER   B 2 134 ? -35.319 -26.055  -51.722 1.00 93.91  ? 135  SER   B O   1 
ATOM   5949 C  CB  . SER   B 2 134 ? -32.733 -27.702  -52.975 1.00 92.34  ? 135  SER   B CB  1 
ATOM   5950 O  OG  . SER   B 2 134 ? -33.282 -28.721  -53.799 1.00 91.85  ? 135  SER   B OG  1 
ATOM   5951 N  N   . SER   B 2 135 ? -35.796 -28.204  -52.341 1.00 94.30  ? 136  SER   B N   1 
ATOM   5952 C  CA  . SER   B 2 135 ? -37.239 -27.997  -52.652 1.00 94.01  ? 136  SER   B CA  1 
ATOM   5953 C  C   . SER   B 2 135 ? -37.991 -27.522  -51.400 1.00 95.84  ? 136  SER   B C   1 
ATOM   5954 O  O   . SER   B 2 135 ? -38.860 -26.639  -51.537 1.00 101.78 ? 136  SER   B O   1 
ATOM   5955 C  CB  . SER   B 2 135 ? -37.879 -29.235  -53.235 1.00 93.19  ? 136  SER   B CB  1 
ATOM   5956 O  OG  . SER   B 2 135 ? -38.158 -30.195  -52.225 1.00 93.85  ? 136  SER   B OG  1 
ATOM   5957 N  N   . GLY   B 2 136 ? -37.671 -28.090  -50.232 1.00 92.16  ? 137  GLY   B N   1 
ATOM   5958 C  CA  . GLY   B 2 136 ? -38.310 -27.764  -48.942 1.00 88.25  ? 137  GLY   B CA  1 
ATOM   5959 C  C   . GLY   B 2 136 ? -39.519 -28.644  -48.662 1.00 86.86  ? 137  GLY   B C   1 
ATOM   5960 O  O   . GLY   B 2 136 ? -40.217 -28.377  -47.666 1.00 86.65  ? 137  GLY   B O   1 
ATOM   5961 N  N   . THR   B 2 137 ? -39.765 -29.652  -49.508 1.00 88.06  ? 138  THR   B N   1 
ATOM   5962 C  CA  . THR   B 2 137 ? -40.859 -30.653  -49.364 1.00 96.74  ? 138  THR   B CA  1 
ATOM   5963 C  C   . THR   B 2 137 ? -40.293 -31.990  -48.867 1.00 100.77 ? 138  THR   B C   1 
ATOM   5964 O  O   . THR   B 2 137 ? -41.101 -32.849  -48.441 1.00 100.18 ? 138  THR   B O   1 
ATOM   5965 C  CB  . THR   B 2 137 ? -41.602 -30.836  -50.693 1.00 97.73  ? 138  THR   B CB  1 
ATOM   5966 O  OG1 . THR   B 2 137 ? -40.624 -31.118  -51.695 1.00 95.90  ? 138  THR   B OG1 1 
ATOM   5967 C  CG2 . THR   B 2 137 ? -42.414 -29.618  -51.078 1.00 97.92  ? 138  THR   B CG2 1 
ATOM   5968 N  N   . GLN   B 2 138 ? -38.965 -32.157  -48.944 1.00 99.79  ? 139  GLN   B N   1 
ATOM   5969 C  CA  . GLN   B 2 138 ? -38.215 -33.355  -48.481 1.00 94.10  ? 139  GLN   B CA  1 
ATOM   5970 C  C   . GLN   B 2 138 ? -37.167 -32.930  -47.446 1.00 92.09  ? 139  GLN   B C   1 
ATOM   5971 O  O   . GLN   B 2 138 ? -36.712 -31.764  -47.486 1.00 90.49  ? 139  GLN   B O   1 
ATOM   5972 C  CB  . GLN   B 2 138 ? -37.522 -34.052  -49.653 1.00 92.91  ? 139  GLN   B CB  1 
ATOM   5973 C  CG  . GLN   B 2 138 ? -38.476 -34.580  -50.714 1.00 91.58  ? 139  GLN   B CG  1 
ATOM   5974 C  CD  . GLN   B 2 138 ? -37.770 -35.439  -51.735 1.00 89.93  ? 139  GLN   B CD  1 
ATOM   5975 O  OE1 . GLN   B 2 138 ? -36.608 -35.214  -52.074 1.00 85.01  ? 139  GLN   B OE1 1 
ATOM   5976 N  NE2 . GLN   B 2 138 ? -38.473 -36.442  -52.236 1.00 91.13  ? 139  GLN   B NE2 1 
ATOM   5977 N  N   . ALA   B 2 139 ? -36.791 -33.853  -46.559 1.00 87.08  ? 140  ALA   B N   1 
ATOM   5978 C  CA  . ALA   B 2 139 ? -35.705 -33.672  -45.572 1.00 84.96  ? 140  ALA   B CA  1 
ATOM   5979 C  C   . ALA   B 2 139 ? -35.003 -35.011  -45.334 1.00 82.43  ? 140  ALA   B C   1 
ATOM   5980 O  O   . ALA   B 2 139 ? -35.632 -36.073  -45.554 1.00 73.60  ? 140  ALA   B O   1 
ATOM   5981 C  CB  . ALA   B 2 139 ? -36.254 -33.095  -44.290 1.00 85.05  ? 140  ALA   B CB  1 
ATOM   5982 N  N   . VAL   B 2 140 ? -33.744 -34.938  -44.897 1.00 83.80  ? 141  VAL   B N   1 
ATOM   5983 C  CA  . VAL   B 2 140 ? -32.888 -36.110  -44.546 1.00 81.71  ? 141  VAL   B CA  1 
ATOM   5984 C  C   . VAL   B 2 140 ? -32.520 -36.009  -43.059 1.00 75.61  ? 141  VAL   B C   1 
ATOM   5985 O  O   . VAL   B 2 140 ? -32.146 -34.903  -42.608 1.00 68.27  ? 141  VAL   B O   1 
ATOM   5986 C  CB  . VAL   B 2 140 ? -31.647 -36.207  -45.459 1.00 82.91  ? 141  VAL   B CB  1 
ATOM   5987 C  CG1 . VAL   B 2 140 ? -30.830 -34.924  -45.490 1.00 83.91  ? 141  VAL   B CG1 1 
ATOM   5988 C  CG2 . VAL   B 2 140 ? -30.762 -37.386  -45.088 1.00 86.05  ? 141  VAL   B CG2 1 
ATOM   5989 N  N   . SER   B 2 141 ? -32.654 -37.126  -42.335 1.00 74.28  ? 142  SER   B N   1 
ATOM   5990 C  CA  . SER   B 2 141 ? -32.280 -37.299  -40.907 1.00 71.76  ? 142  SER   B CA  1 
ATOM   5991 C  C   . SER   B 2 141 ? -31.098 -38.271  -40.802 1.00 74.18  ? 142  SER   B C   1 
ATOM   5992 O  O   . SER   B 2 141 ? -31.035 -39.212  -41.619 1.00 71.29  ? 142  SER   B O   1 
ATOM   5993 C  CB  . SER   B 2 141 ? -33.453 -37.802  -40.112 1.00 67.32  ? 142  SER   B CB  1 
ATOM   5994 O  OG  . SER   B 2 141 ? -33.777 -39.129  -40.494 1.00 62.86  ? 142  SER   B OG  1 
ATOM   5995 N  N   . GLY   B 2 142 ? -30.211 -38.044  -39.828 1.00 77.26  ? 143  GLY   B N   1 
ATOM   5996 C  CA  . GLY   B 2 142 ? -29.131 -38.969  -39.428 1.00 76.75  ? 143  GLY   B CA  1 
ATOM   5997 C  C   . GLY   B 2 142 ? -29.252 -39.344  -37.961 1.00 76.01  ? 143  GLY   B C   1 
ATOM   5998 O  O   . GLY   B 2 142 ? -29.726 -38.505  -37.175 1.00 74.45  ? 143  GLY   B O   1 
ATOM   5999 N  N   . SER   B 2 143 ? -28.836 -40.560  -37.597 1.00 78.65  ? 144  SER   B N   1 
ATOM   6000 C  CA  . SER   B 2 143 ? -29.053 -41.156  -36.252 1.00 79.11  ? 144  SER   B CA  1 
ATOM   6001 C  C   . SER   B 2 143 ? -27.829 -41.957  -35.784 1.00 78.10  ? 144  SER   B C   1 
ATOM   6002 O  O   . SER   B 2 143 ? -27.008 -42.372  -36.628 1.00 78.16  ? 144  SER   B O   1 
ATOM   6003 C  CB  . SER   B 2 143 ? -30.298 -42.009  -36.259 1.00 76.30  ? 144  SER   B CB  1 
ATOM   6004 O  OG  . SER   B 2 143 ? -30.418 -42.759  -35.060 1.00 72.90  ? 144  SER   B OG  1 
ATOM   6005 N  N   . LYS   B 2 144 ? -27.739 -42.171  -34.469 1.00 77.17  ? 145  LYS   B N   1 
ATOM   6006 C  CA  . LYS   B 2 144 ? -26.733 -43.042  -33.804 1.00 73.36  ? 145  LYS   B CA  1 
ATOM   6007 C  C   . LYS   B 2 144 ? -26.987 -44.508  -34.178 1.00 68.56  ? 145  LYS   B C   1 
ATOM   6008 O  O   . LYS   B 2 144 ? -26.051 -45.319  -34.031 1.00 69.09  ? 145  LYS   B O   1 
ATOM   6009 C  CB  . LYS   B 2 144 ? -26.793 -42.842  -32.287 1.00 71.29  ? 145  LYS   B CB  1 
ATOM   6010 C  CG  . LYS   B 2 144 ? -26.261 -41.502  -31.803 1.00 72.08  ? 145  LYS   B CG  1 
ATOM   6011 C  CD  . LYS   B 2 144 ? -26.251 -41.365  -30.295 1.00 70.65  ? 145  LYS   B CD  1 
ATOM   6012 C  CE  . LYS   B 2 144 ? -25.730 -40.026  -29.820 1.00 69.22  ? 145  LYS   B CE  1 
ATOM   6013 N  NZ  . LYS   B 2 144 ? -24.414 -39.699  -30.418 1.00 69.76  ? 145  LYS   B NZ  1 
ATOM   6014 N  N   . ASP   B 2 145 ? -28.198 -44.825  -34.649 1.00 64.19  ? 146  ASP   B N   1 
ATOM   6015 C  CA  . ASP   B 2 145 ? -28.565 -46.184  -35.159 1.00 65.08  ? 146  ASP   B CA  1 
ATOM   6016 C  C   . ASP   B 2 145 ? -27.863 -46.467  -36.498 1.00 61.60  ? 146  ASP   B C   1 
ATOM   6017 O  O   . ASP   B 2 145 ? -28.110 -47.545  -37.073 1.00 57.54  ? 146  ASP   B O   1 
ATOM   6018 C  CB  . ASP   B 2 145 ? -30.082 -46.357  -35.277 1.00 65.36  ? 146  ASP   B CB  1 
ATOM   6019 C  CG  . ASP   B 2 145 ? -30.735 -45.676  -36.469 1.00 67.79  ? 146  ASP   B CG  1 
ATOM   6020 O  OD1 . ASP   B 2 145 ? -30.028 -44.985  -37.229 1.00 65.52  ? 146  ASP   B OD1 1 
ATOM   6021 O  OD2 . ASP   B 2 145 ? -31.955 -45.855  -36.631 1.00 74.49  ? 146  ASP   B OD2 1 
ATOM   6022 N  N   . ILE   B 2 146 ? -27.067 -45.506  -36.982 1.00 63.62  ? 147  ILE   B N   1 
ATOM   6023 C  CA  . ILE   B 2 146 ? -26.128 -45.648  -38.153 1.00 67.53  ? 147  ILE   B CA  1 
ATOM   6024 C  C   . ILE   B 2 146 ? -26.881 -45.399  -39.479 1.00 69.29  ? 147  ILE   B C   1 
ATOM   6025 O  O   . ILE   B 2 146 ? -26.222 -45.246  -40.534 1.00 66.44  ? 147  ILE   B O   1 
ATOM   6026 C  CB  . ILE   B 2 146 ? -25.389 -47.011  -38.117 1.00 67.39  ? 147  ILE   B CB  1 
ATOM   6027 C  CG1 . ILE   B 2 146 ? -24.699 -47.234  -36.763 1.00 67.74  ? 147  ILE   B CG1 1 
ATOM   6028 C  CG2 . ILE   B 2 146 ? -24.398 -47.142  -39.270 1.00 68.64  ? 147  ILE   B CG2 1 
ATOM   6029 C  CD1 . ILE   B 2 146 ? -24.220 -48.648  -36.511 1.00 65.11  ? 147  ILE   B CD1 1 
ATOM   6030 N  N   . CYS   B 2 147 ? -28.210 -45.288  -39.428 1.00 71.27  ? 148  CYS   B N   1 
ATOM   6031 C  CA  . CYS   B 2 147 ? -29.075 -45.066  -40.628 1.00 72.29  ? 148  CYS   B CA  1 
ATOM   6032 C  C   . CYS   B 2 147 ? -29.155 -43.579  -41.000 1.00 72.19  ? 148  CYS   B C   1 
ATOM   6033 O  O   . CYS   B 2 147 ? -28.926 -42.725  -40.122 1.00 70.84  ? 148  CYS   B O   1 
ATOM   6034 C  CB  . CYS   B 2 147 ? -30.482 -45.613  -40.427 1.00 73.34  ? 148  CYS   B CB  1 
ATOM   6035 S  SG  . CYS   B 2 147 ? -30.529 -47.423  -40.407 1.00 78.86  ? 148  CYS   B SG  1 
ATOM   6036 N  N   . ILE   B 2 148 ? -29.436 -43.314  -42.281 1.00 71.76  ? 149  ILE   B N   1 
ATOM   6037 C  CA  . ILE   B 2 148 ? -29.820 -41.989  -42.853 1.00 69.34  ? 149  ILE   B CA  1 
ATOM   6038 C  C   . ILE   B 2 148 ? -31.148 -42.177  -43.595 1.00 69.21  ? 149  ILE   B C   1 
ATOM   6039 O  O   . ILE   B 2 148 ? -31.222 -43.099  -44.431 1.00 69.00  ? 149  ILE   B O   1 
ATOM   6040 C  CB  . ILE   B 2 148 ? -28.721 -41.447  -43.786 1.00 70.37  ? 149  ILE   B CB  1 
ATOM   6041 C  CG1 . ILE   B 2 148 ? -27.423 -41.167  -43.024 1.00 72.48  ? 149  ILE   B CG1 1 
ATOM   6042 C  CG2 . ILE   B 2 148 ? -29.210 -40.217  -44.540 1.00 72.68  ? 149  ILE   B CG2 1 
ATOM   6043 C  CD1 . ILE   B 2 148 ? -26.328 -40.542  -43.863 1.00 72.60  ? 149  ILE   B CD1 1 
ATOM   6044 N  N   . LYS   B 2 149 ? -32.148 -41.340  -43.304 1.00 72.51  ? 150  LYS   B N   1 
ATOM   6045 C  CA  . LYS   B 2 149 ? -33.527 -41.464  -43.858 1.00 74.06  ? 150  LYS   B CA  1 
ATOM   6046 C  C   . LYS   B 2 149 ? -33.888 -40.196  -44.645 1.00 71.38  ? 150  LYS   B C   1 
ATOM   6047 O  O   . LYS   B 2 149 ? -33.541 -39.097  -44.184 1.00 66.40  ? 150  LYS   B O   1 
ATOM   6048 C  CB  . LYS   B 2 149 ? -34.518 -41.747  -42.724 1.00 72.56  ? 150  LYS   B CB  1 
ATOM   6049 C  CG  . LYS   B 2 149 ? -34.463 -43.168  -42.177 1.00 72.20  ? 150  LYS   B CG  1 
ATOM   6050 C  CD  . LYS   B 2 149 ? -35.167 -43.355  -40.848 1.00 71.75  ? 150  LYS   B CD  1 
ATOM   6051 C  CE  . LYS   B 2 149 ? -34.851 -44.687  -40.199 1.00 72.60  ? 150  LYS   B CE  1 
ATOM   6052 N  NZ  . LYS   B 2 149 ? -35.504 -45.816  -40.904 1.00 75.32  ? 150  LYS   B NZ  1 
ATOM   6053 N  N   . VAL   B 2 150 ? -34.535 -40.361  -45.803 1.00 74.30  ? 151  VAL   B N   1 
ATOM   6054 C  CA  . VAL   B 2 150 ? -35.127 -39.257  -46.619 1.00 78.62  ? 151  VAL   B CA  1 
ATOM   6055 C  C   . VAL   B 2 150 ? -36.639 -39.244  -46.366 1.00 77.47  ? 151  VAL   B C   1 
ATOM   6056 O  O   . VAL   B 2 150 ? -37.287 -40.298  -46.558 1.00 76.74  ? 151  VAL   B O   1 
ATOM   6057 C  CB  . VAL   B 2 150 ? -34.799 -39.407  -48.119 1.00 80.07  ? 151  VAL   B CB  1 
ATOM   6058 C  CG1 . VAL   B 2 150 ? -35.468 -38.324  -48.956 1.00 80.38  ? 151  VAL   B CG1 1 
ATOM   6059 C  CG2 . VAL   B 2 150 ? -33.298 -39.415  -48.368 1.00 79.47  ? 151  VAL   B CG2 1 
ATOM   6060 N  N   . TRP   B 2 151 ? -37.172 -38.093  -45.950 1.00 79.83  ? 152  TRP   B N   1 
ATOM   6061 C  CA  . TRP   B 2 151 ? -38.574 -37.924  -45.486 1.00 84.97  ? 152  TRP   B CA  1 
ATOM   6062 C  C   . TRP   B 2 151 ? -39.400 -37.168  -46.531 1.00 84.56  ? 152  TRP   B C   1 
ATOM   6063 O  O   . TRP   B 2 151 ? -38.868 -36.197  -47.099 1.00 82.83  ? 152  TRP   B O   1 
ATOM   6064 C  CB  . TRP   B 2 151 ? -38.591 -37.180  -44.148 1.00 86.59  ? 152  TRP   B CB  1 
ATOM   6065 C  CG  . TRP   B 2 151 ? -37.992 -37.952  -43.015 1.00 88.32  ? 152  TRP   B CG  1 
ATOM   6066 C  CD1 . TRP   B 2 151 ? -36.667 -38.109  -42.734 1.00 88.16  ? 152  TRP   B CD1 1 
ATOM   6067 C  CD2 . TRP   B 2 151 ? -38.708 -38.669  -41.996 1.00 90.71  ? 152  TRP   B CD2 1 
ATOM   6068 N  NE1 . TRP   B 2 151 ? -36.510 -38.877  -41.612 1.00 89.45  ? 152  TRP   B NE1 1 
ATOM   6069 C  CE2 . TRP   B 2 151 ? -37.743 -39.234  -41.136 1.00 91.57  ? 152  TRP   B CE2 1 
ATOM   6070 C  CE3 . TRP   B 2 151 ? -40.064 -38.889  -41.728 1.00 90.11  ? 152  TRP   B CE3 1 
ATOM   6071 C  CZ2 . TRP   B 2 151 ? -38.095 -40.001  -40.026 1.00 92.48  ? 152  TRP   B CZ2 1 
ATOM   6072 C  CZ3 . TRP   B 2 151 ? -40.411 -39.646  -40.631 1.00 91.77  ? 152  TRP   B CZ3 1 
ATOM   6073 C  CH2 . TRP   B 2 151 ? -39.438 -40.194  -39.793 1.00 92.50  ? 152  TRP   B CH2 1 
ATOM   6074 N  N   . ASP   B 2 152 ? -40.648 -37.596  -46.756 1.00 87.69  ? 153  ASP   B N   1 
ATOM   6075 C  CA  . ASP   B 2 152 ? -41.702 -36.781  -47.423 1.00 91.26  ? 153  ASP   B CA  1 
ATOM   6076 C  C   . ASP   B 2 152 ? -42.440 -35.986  -46.338 1.00 85.93  ? 153  ASP   B C   1 
ATOM   6077 O  O   . ASP   B 2 152 ? -43.250 -36.598  -45.600 1.00 76.87  ? 153  ASP   B O   1 
ATOM   6078 C  CB  . ASP   B 2 152 ? -42.661 -37.643  -48.256 1.00 95.33  ? 153  ASP   B CB  1 
ATOM   6079 C  CG  . ASP   B 2 152 ? -43.623 -36.849  -49.134 1.00 96.38  ? 153  ASP   B CG  1 
ATOM   6080 O  OD1 . ASP   B 2 152 ? -43.432 -35.621  -49.273 1.00 91.90  ? 153  ASP   B OD1 1 
ATOM   6081 O  OD2 . ASP   B 2 152 ? -44.561 -37.468  -49.677 1.00 99.43  ? 153  ASP   B OD2 1 
ATOM   6082 N  N   . LEU   B 2 153 ? -42.154 -34.681  -46.237 1.00 84.97  ? 154  LEU   B N   1 
ATOM   6083 C  CA  . LEU   B 2 153 ? -42.757 -33.760  -45.232 1.00 87.42  ? 154  LEU   B CA  1 
ATOM   6084 C  C   . LEU   B 2 153 ? -44.250 -33.576  -45.526 1.00 91.71  ? 154  LEU   B C   1 
ATOM   6085 O  O   . LEU   B 2 153 ? -44.992 -33.237  -44.585 1.00 96.05  ? 154  LEU   B O   1 
ATOM   6086 C  CB  . LEU   B 2 153 ? -42.027 -32.414  -45.256 1.00 84.54  ? 154  LEU   B CB  1 
ATOM   6087 C  CG  . LEU   B 2 153 ? -40.586 -32.434  -44.750 1.00 87.42  ? 154  LEU   B CG  1 
ATOM   6088 C  CD1 . LEU   B 2 153 ? -39.975 -31.042  -44.816 1.00 89.74  ? 154  LEU   B CD1 1 
ATOM   6089 C  CD2 . LEU   B 2 153 ? -40.503 -32.981  -43.331 1.00 88.23  ? 154  LEU   B CD2 1 
ATOM   6090 N  N   . ALA   B 2 154 ? -44.659 -33.785  -46.782 1.00 94.73  ? 155  ALA   B N   1 
ATOM   6091 C  CA  . ALA   B 2 154 ? -46.067 -33.753  -47.241 1.00 95.26  ? 155  ALA   B CA  1 
ATOM   6092 C  C   . ALA   B 2 154 ? -46.840 -34.929  -46.631 1.00 91.73  ? 155  ALA   B C   1 
ATOM   6093 O  O   . ALA   B 2 154 ? -47.846 -34.674  -45.949 1.00 88.48  ? 155  ALA   B O   1 
ATOM   6094 C  CB  . ALA   B 2 154 ? -46.117 -33.783  -48.750 1.00 101.17 ? 155  ALA   B CB  1 
ATOM   6095 N  N   . GLN   B 2 155 ? -46.377 -36.164  -46.858 1.00 94.82  ? 156  GLN   B N   1 
ATOM   6096 C  CA  . GLN   B 2 155 ? -47.113 -37.417  -46.521 1.00 100.96 ? 156  GLN   B CA  1 
ATOM   6097 C  C   . GLN   B 2 155 ? -46.727 -37.928  -45.122 1.00 99.28  ? 156  GLN   B C   1 
ATOM   6098 O  O   . GLN   B 2 155 ? -47.391 -38.878  -44.648 1.00 93.03  ? 156  GLN   B O   1 
ATOM   6099 C  CB  . GLN   B 2 155 ? -46.853 -38.489  -47.583 1.00 104.98 ? 156  GLN   B CB  1 
ATOM   6100 C  CG  . GLN   B 2 155 ? -47.524 -38.193  -48.917 1.00 110.10 ? 156  GLN   B CG  1 
ATOM   6101 C  CD  . GLN   B 2 155 ? -47.263 -39.254  -49.961 1.00 115.82 ? 156  GLN   B CD  1 
ATOM   6102 O  OE1 . GLN   B 2 155 ? -46.596 -40.255  -49.709 1.00 115.03 ? 156  GLN   B OE1 1 
ATOM   6103 N  NE2 . GLN   B 2 155 ? -47.795 -39.040  -51.154 1.00 119.89 ? 156  GLN   B NE2 1 
ATOM   6104 N  N   . GLN   B 2 156 ? -45.710 -37.327  -44.488 1.00 97.81  ? 157  GLN   B N   1 
ATOM   6105 C  CA  . GLN   B 2 156 ? -45.227 -37.694  -43.127 1.00 95.56  ? 157  GLN   B CA  1 
ATOM   6106 C  C   . GLN   B 2 156 ? -44.768 -39.159  -43.130 1.00 92.91  ? 157  GLN   B C   1 
ATOM   6107 O  O   . GLN   B 2 156 ? -45.287 -39.943  -42.306 1.00 92.05  ? 157  GLN   B O   1 
ATOM   6108 C  CB  . GLN   B 2 156 ? -46.333 -37.480  -42.089 1.00 94.84  ? 157  GLN   B CB  1 
ATOM   6109 C  CG  . GLN   B 2 156 ? -47.057 -36.146  -42.227 1.00 93.79  ? 157  GLN   B CG  1 
ATOM   6110 C  CD  . GLN   B 2 156 ? -48.218 -35.972  -41.275 1.00 91.52  ? 157  GLN   B CD  1 
ATOM   6111 O  OE1 . GLN   B 2 156 ? -48.603 -34.850  -40.956 1.00 89.97  ? 157  GLN   B OE1 1 
ATOM   6112 N  NE2 . GLN   B 2 156 ? -48.794 -37.073  -40.812 1.00 88.61  ? 157  GLN   B NE2 1 
ATOM   6113 N  N   . VAL   B 2 157 ? -43.849 -39.515  -44.036 1.00 90.90  ? 158  VAL   B N   1 
ATOM   6114 C  CA  . VAL   B 2 157 ? -43.320 -40.905  -44.197 1.00 87.21  ? 158  VAL   B CA  1 
ATOM   6115 C  C   . VAL   B 2 157 ? -41.835 -40.865  -44.581 1.00 84.30  ? 158  VAL   B C   1 
ATOM   6116 O  O   . VAL   B 2 157 ? -41.368 -39.827  -45.096 1.00 79.97  ? 158  VAL   B O   1 
ATOM   6117 C  CB  . VAL   B 2 157 ? -44.129 -41.708  -45.234 1.00 83.27  ? 158  VAL   B CB  1 
ATOM   6118 C  CG1 . VAL   B 2 157 ? -45.540 -42.004  -44.748 1.00 82.38  ? 158  VAL   B CG1 1 
ATOM   6119 C  CG2 . VAL   B 2 157 ? -44.155 -41.024  -46.593 1.00 83.23  ? 158  VAL   B CG2 1 
ATOM   6120 N  N   . VAL   B 2 158 ? -41.137 -41.975  -44.325 1.00 82.91  ? 159  VAL   B N   1 
ATOM   6121 C  CA  . VAL   B 2 158 ? -39.768 -42.282  -44.837 1.00 81.58  ? 159  VAL   B CA  1 
ATOM   6122 C  C   . VAL   B 2 158 ? -39.922 -42.838  -46.258 1.00 81.87  ? 159  VAL   B C   1 
ATOM   6123 O  O   . VAL   B 2 158 ? -40.494 -43.941  -46.401 1.00 78.81  ? 159  VAL   B O   1 
ATOM   6124 C  CB  . VAL   B 2 158 ? -39.037 -43.275  -43.906 1.00 78.02  ? 159  VAL   B CB  1 
ATOM   6125 C  CG1 . VAL   B 2 158 ? -37.697 -43.726  -44.465 1.00 77.33  ? 159  VAL   B CG1 1 
ATOM   6126 C  CG2 . VAL   B 2 158 ? -38.854 -42.706  -42.509 1.00 78.28  ? 159  VAL   B CG2 1 
ATOM   6127 N  N   . LEU   B 2 159 ? -39.454 -42.098  -47.269 1.00 82.53  ? 160  LEU   B N   1 
ATOM   6128 C  CA  . LEU   B 2 159 ? -39.411 -42.571  -48.680 1.00 86.93  ? 160  LEU   B CA  1 
ATOM   6129 C  C   . LEU   B 2 159 ? -38.285 -43.602  -48.814 1.00 88.10  ? 160  LEU   B C   1 
ATOM   6130 O  O   . LEU   B 2 159 ? -38.541 -44.694  -49.365 1.00 84.69  ? 160  LEU   B O   1 
ATOM   6131 C  CB  . LEU   B 2 159 ? -39.185 -41.386  -49.627 1.00 86.66  ? 160  LEU   B CB  1 
ATOM   6132 C  CG  . LEU   B 2 159 ? -40.297 -40.338  -49.672 1.00 88.69  ? 160  LEU   B CG  1 
ATOM   6133 C  CD1 . LEU   B 2 159 ? -39.938 -39.223  -50.643 1.00 88.34  ? 160  LEU   B CD1 1 
ATOM   6134 C  CD2 . LEU   B 2 159 ? -41.636 -40.960  -50.049 1.00 89.28  ? 160  LEU   B CD2 1 
ATOM   6135 N  N   . SER   B 2 160 ? -37.094 -43.258  -48.312 1.00 87.28  ? 161  SER   B N   1 
ATOM   6136 C  CA  . SER   B 2 160 ? -35.852 -44.067  -48.399 1.00 87.41  ? 161  SER   B CA  1 
ATOM   6137 C  C   . SER   B 2 160 ? -35.195 -44.178  -47.018 1.00 88.99  ? 161  SER   B C   1 
ATOM   6138 O  O   . SER   B 2 160 ? -35.191 -43.166  -46.284 1.00 87.28  ? 161  SER   B O   1 
ATOM   6139 C  CB  . SER   B 2 160 ? -34.906 -43.463  -49.402 1.00 87.09  ? 161  SER   B CB  1 
ATOM   6140 O  OG  . SER   B 2 160 ? -35.498 -43.410  -50.690 1.00 85.60  ? 161  SER   B OG  1 
ATOM   6141 N  N   . SER   B 2 161 ? -34.654 -45.360  -46.695 1.00 89.24  ? 162  SER   B N   1 
ATOM   6142 C  CA  . SER   B 2 161 ? -33.871 -45.659  -45.464 1.00 85.11  ? 162  SER   B CA  1 
ATOM   6143 C  C   . SER   B 2 161 ? -32.548 -46.335  -45.846 1.00 83.05  ? 162  SER   B C   1 
ATOM   6144 O  O   . SER   B 2 161 ? -32.599 -47.488  -46.320 1.00 82.89  ? 162  SER   B O   1 
ATOM   6145 C  CB  . SER   B 2 161 ? -34.661 -46.519  -44.514 1.00 84.70  ? 162  SER   B CB  1 
ATOM   6146 O  OG  . SER   B 2 161 ? -33.997 -46.616  -43.263 1.00 86.72  ? 162  SER   B OG  1 
ATOM   6147 N  N   . TYR   B 2 162 ? -31.416 -45.651  -45.631 1.00 81.31  ? 163  TYR   B N   1 
ATOM   6148 C  CA  . TYR   B 2 162 ? -30.056 -46.100  -46.036 1.00 81.48  ? 163  TYR   B CA  1 
ATOM   6149 C  C   . TYR   B 2 162 ? -29.187 -46.405  -44.805 1.00 81.79  ? 163  TYR   B C   1 
ATOM   6150 O  O   . TYR   B 2 162 ? -29.012 -45.511  -43.955 1.00 78.12  ? 163  TYR   B O   1 
ATOM   6151 C  CB  . TYR   B 2 162 ? -29.367 -45.033  -46.889 1.00 82.37  ? 163  TYR   B CB  1 
ATOM   6152 C  CG  . TYR   B 2 162 ? -30.160 -44.518  -48.066 1.00 85.72  ? 163  TYR   B CG  1 
ATOM   6153 C  CD1 . TYR   B 2 162 ? -30.577 -45.367  -49.081 1.00 85.13  ? 163  TYR   B CD1 1 
ATOM   6154 C  CD2 . TYR   B 2 162 ? -30.464 -43.170  -48.189 1.00 84.12  ? 163  TYR   B CD2 1 
ATOM   6155 C  CE1 . TYR   B 2 162 ? -31.292 -44.897  -50.171 1.00 84.81  ? 163  TYR   B CE1 1 
ATOM   6156 C  CE2 . TYR   B 2 162 ? -31.175 -42.683  -49.274 1.00 84.46  ? 163  TYR   B CE2 1 
ATOM   6157 C  CZ  . TYR   B 2 162 ? -31.589 -43.549  -50.271 1.00 85.24  ? 163  TYR   B CZ  1 
ATOM   6158 O  OH  . TYR   B 2 162 ? -32.295 -43.076  -51.340 1.00 82.29  ? 163  TYR   B OH  1 
ATOM   6159 N  N   . ARG   B 2 163 ? -28.655 -47.633  -44.723 1.00 82.42  ? 164  ARG   B N   1 
ATOM   6160 C  CA  . ARG   B 2 163 ? -27.546 -48.020  -43.806 1.00 81.05  ? 164  ARG   B CA  1 
ATOM   6161 C  C   . ARG   B 2 163 ? -26.255 -48.060  -44.633 1.00 77.39  ? 164  ARG   B C   1 
ATOM   6162 O  O   . ARG   B 2 163 ? -25.800 -49.161  -44.986 1.00 79.18  ? 164  ARG   B O   1 
ATOM   6163 C  CB  . ARG   B 2 163 ? -27.842 -49.351  -43.101 1.00 83.32  ? 164  ARG   B CB  1 
ATOM   6164 C  CG  . ARG   B 2 163 ? -26.686 -49.885  -42.263 1.00 89.47  ? 164  ARG   B CG  1 
ATOM   6165 C  CD  . ARG   B 2 163 ? -27.025 -51.067  -41.371 1.00 93.88  ? 164  ARG   B CD  1 
ATOM   6166 N  NE  . ARG   B 2 163 ? -27.430 -50.659  -40.029 1.00 100.47 ? 164  ARG   B NE  1 
ATOM   6167 C  CZ  . ARG   B 2 163 ? -28.686 -50.480  -39.617 1.00 103.10 ? 164  ARG   B CZ  1 
ATOM   6168 N  NH1 . ARG   B 2 163 ? -28.920 -50.106  -38.370 1.00 103.25 ? 164  ARG   B NH1 1 
ATOM   6169 N  NH2 . ARG   B 2 163 ? -29.707 -50.674  -40.436 1.00 105.85 ? 164  ARG   B NH2 1 
ATOM   6170 N  N   . ALA   B 2 164 ? -25.712 -46.886  -44.961 1.00 75.07  ? 165  ALA   B N   1 
ATOM   6171 C  CA  . ALA   B 2 164 ? -24.471 -46.717  -45.752 1.00 72.90  ? 165  ALA   B CA  1 
ATOM   6172 C  C   . ALA   B 2 164 ? -23.255 -46.810  -44.830 1.00 70.82  ? 165  ALA   B C   1 
ATOM   6173 O  O   . ALA   B 2 164 ? -22.227 -47.368  -45.257 1.00 73.12  ? 165  ALA   B O   1 
ATOM   6174 C  CB  . ALA   B 2 164 ? -24.494 -45.394  -46.472 1.00 72.40  ? 165  ALA   B CB  1 
ATOM   6175 N  N   . HIS   B 2 165 ? -23.384 -46.273  -43.615 1.00 69.61  ? 166  HIS   B N   1 
ATOM   6176 C  CA  . HIS   B 2 165 ? -22.285 -46.088  -42.631 1.00 67.57  ? 166  HIS   B CA  1 
ATOM   6177 C  C   . HIS   B 2 165 ? -22.125 -47.327  -41.742 1.00 68.68  ? 166  HIS   B C   1 
ATOM   6178 O  O   . HIS   B 2 165 ? -23.040 -48.185  -41.735 1.00 69.49  ? 166  HIS   B O   1 
ATOM   6179 C  CB  . HIS   B 2 165 ? -22.553 -44.839  -41.789 1.00 66.97  ? 166  HIS   B CB  1 
ATOM   6180 C  CG  . HIS   B 2 165 ? -22.350 -43.560  -42.527 1.00 64.03  ? 166  HIS   B CG  1 
ATOM   6181 N  ND1 . HIS   B 2 165 ? -21.093 -43.094  -42.856 1.00 61.33  ? 166  HIS   B ND1 1 
ATOM   6182 C  CD2 . HIS   B 2 165 ? -23.230 -42.640  -42.974 1.00 64.21  ? 166  HIS   B CD2 1 
ATOM   6183 C  CE1 . HIS   B 2 165 ? -21.203 -41.939  -43.475 1.00 62.21  ? 166  HIS   B CE1 1 
ATOM   6184 N  NE2 . HIS   B 2 165 ? -22.507 -41.641  -43.564 1.00 65.16  ? 166  HIS   B NE2 1 
ATOM   6185 N  N   . ALA   B 2 166 ? -21.003 -47.398  -41.014 1.00 67.99  ? 167  ALA   B N   1 
ATOM   6186 C  CA  . ALA   B 2 166 ? -20.629 -48.510  -40.103 1.00 70.23  ? 167  ALA   B CA  1 
ATOM   6187 C  C   . ALA   B 2 166 ? -20.641 -48.052  -38.636 1.00 67.96  ? 167  ALA   B C   1 
ATOM   6188 O  O   . ALA   B 2 166 ? -20.472 -48.913  -37.757 1.00 69.19  ? 167  ALA   B O   1 
ATOM   6189 C  CB  . ALA   B 2 166 ? -19.276 -49.052  -40.496 1.00 69.27  ? 167  ALA   B CB  1 
ATOM   6190 N  N   . ALA   B 2 167 ? -20.823 -46.753  -38.381 1.00 67.99  ? 168  ALA   B N   1 
ATOM   6191 C  CA  . ALA   B 2 167 ? -20.903 -46.150  -37.031 1.00 68.42  ? 168  ALA   B CA  1 
ATOM   6192 C  C   . ALA   B 2 167 ? -21.967 -45.044  -37.023 1.00 69.59  ? 168  ALA   B C   1 
ATOM   6193 O  O   . ALA   B 2 167 ? -22.568 -44.782  -38.083 1.00 74.34  ? 168  ALA   B O   1 
ATOM   6194 C  CB  . ALA   B 2 167 ? -19.548 -45.616  -36.633 1.00 68.30  ? 168  ALA   B CB  1 
ATOM   6195 N  N   . GLN   B 2 168 ? -22.182 -44.424  -35.861 1.00 69.61  ? 169  GLN   B N   1 
ATOM   6196 C  CA  . GLN   B 2 168 ? -23.108 -43.279  -35.652 1.00 67.85  ? 169  GLN   B CA  1 
ATOM   6197 C  C   . GLN   B 2 168 ? -22.948 -42.263  -36.787 1.00 67.08  ? 169  GLN   B C   1 
ATOM   6198 O  O   . GLN   B 2 168 ? -21.796 -41.931  -37.120 1.00 65.43  ? 169  GLN   B O   1 
ATOM   6199 C  CB  . GLN   B 2 168 ? -22.801 -42.555  -34.340 1.00 70.18  ? 169  GLN   B CB  1 
ATOM   6200 C  CG  . GLN   B 2 168 ? -22.814 -43.453  -33.117 1.00 72.51  ? 169  GLN   B CG  1 
ATOM   6201 C  CD  . GLN   B 2 168 ? -22.694 -42.659  -31.841 1.00 73.48  ? 169  GLN   B CD  1 
ATOM   6202 O  OE1 . GLN   B 2 168 ? -22.074 -41.597  -31.800 1.00 68.53  ? 169  GLN   B OE1 1 
ATOM   6203 N  NE2 . GLN   B 2 168 ? -23.298 -43.180  -30.785 1.00 74.13  ? 169  GLN   B NE2 1 
ATOM   6204 N  N   . VAL   B 2 169 ? -24.066 -41.783  -37.340 1.00 68.12  ? 170  VAL   B N   1 
ATOM   6205 C  CA  . VAL   B 2 169 ? -24.098 -40.636  -38.294 1.00 68.27  ? 170  VAL   B CA  1 
ATOM   6206 C  C   . VAL   B 2 169 ? -24.012 -39.363  -37.451 1.00 65.69  ? 170  VAL   B C   1 
ATOM   6207 O  O   . VAL   B 2 169 ? -24.835 -39.208  -36.543 1.00 65.61  ? 170  VAL   B O   1 
ATOM   6208 C  CB  . VAL   B 2 169 ? -25.359 -40.640  -39.181 1.00 70.43  ? 170  VAL   B CB  1 
ATOM   6209 C  CG1 . VAL   B 2 169 ? -25.296 -39.541  -40.233 1.00 71.41  ? 170  VAL   B CG1 1 
ATOM   6210 C  CG2 . VAL   B 2 169 ? -25.607 -41.994  -39.834 1.00 67.59  ? 170  VAL   B CG2 1 
ATOM   6211 N  N   . THR   B 2 170 ? -23.036 -38.505  -37.739 1.00 66.89  ? 171  THR   B N   1 
ATOM   6212 C  CA  . THR   B 2 170 ? -22.697 -37.302  -36.937 1.00 67.31  ? 171  THR   B CA  1 
ATOM   6213 C  C   . THR   B 2 170 ? -23.486 -36.093  -37.451 1.00 72.63  ? 171  THR   B C   1 
ATOM   6214 O  O   . THR   B 2 170 ? -24.015 -35.330  -36.615 1.00 75.27  ? 171  THR   B O   1 
ATOM   6215 C  CB  . THR   B 2 170 ? -21.188 -37.038  -36.987 1.00 67.34  ? 171  THR   B CB  1 
ATOM   6216 O  OG1 . THR   B 2 170 ? -20.514 -38.249  -36.639 1.00 71.08  ? 171  THR   B OG1 1 
ATOM   6217 C  CG2 . THR   B 2 170 ? -20.759 -35.918  -36.064 1.00 66.79  ? 171  THR   B CG2 1 
ATOM   6218 N  N   . CYS   B 2 171 ? -23.547 -35.925  -38.775 1.00 74.89  ? 172  CYS   B N   1 
ATOM   6219 C  CA  . CYS   B 2 171 ? -24.041 -34.698  -39.451 1.00 75.10  ? 172  CYS   B CA  1 
ATOM   6220 C  C   . CYS   B 2 171 ? -24.472 -35.019  -40.887 1.00 76.23  ? 172  CYS   B C   1 
ATOM   6221 O  O   . CYS   B 2 171 ? -23.724 -35.725  -41.589 1.00 79.19  ? 172  CYS   B O   1 
ATOM   6222 C  CB  . CYS   B 2 171 ? -22.952 -33.632  -39.453 1.00 77.28  ? 172  CYS   B CB  1 
ATOM   6223 S  SG  . CYS   B 2 171 ? -23.391 -32.147  -40.392 1.00 79.21  ? 172  CYS   B SG  1 
ATOM   6224 N  N   . VAL   B 2 172 ? -25.642 -34.522  -41.295 1.00 75.08  ? 173  VAL   B N   1 
ATOM   6225 C  CA  . VAL   B 2 172 ? -26.132 -34.555  -42.706 1.00 72.56  ? 173  VAL   B CA  1 
ATOM   6226 C  C   . VAL   B 2 172 ? -26.445 -33.115  -43.134 1.00 72.95  ? 173  VAL   B C   1 
ATOM   6227 O  O   . VAL   B 2 172 ? -27.050 -32.383  -42.328 1.00 74.53  ? 173  VAL   B O   1 
ATOM   6228 C  CB  . VAL   B 2 172 ? -27.353 -35.481  -42.876 1.00 68.76  ? 173  VAL   B CB  1 
ATOM   6229 C  CG1 . VAL   B 2 172 ? -27.039 -36.899  -42.434 1.00 68.92  ? 173  VAL   B CG1 1 
ATOM   6230 C  CG2 . VAL   B 2 172 ? -28.592 -34.956  -42.162 1.00 67.75  ? 173  VAL   B CG2 1 
ATOM   6231 N  N   . ALA   B 2 173 ? -26.032 -32.728  -44.345 1.00 74.27  ? 174  ALA   B N   1 
ATOM   6232 C  CA  . ALA   B 2 173 ? -26.243 -31.380  -44.924 1.00 76.49  ? 174  ALA   B CA  1 
ATOM   6233 C  C   . ALA   B 2 173 ? -26.798 -31.506  -46.349 1.00 79.24  ? 174  ALA   B C   1 
ATOM   6234 O  O   . ALA   B 2 173 ? -26.079 -32.038  -47.218 1.00 78.07  ? 174  ALA   B O   1 
ATOM   6235 C  CB  . ALA   B 2 173 ? -24.950 -30.605  -44.902 1.00 75.83  ? 174  ALA   B CB  1 
ATOM   6236 N  N   . ALA   B 2 174 ? -28.034 -31.035  -46.560 1.00 79.27  ? 175  ALA   B N   1 
ATOM   6237 C  CA  . ALA   B 2 174 ? -28.727 -30.971  -47.869 1.00 74.64  ? 175  ALA   B CA  1 
ATOM   6238 C  C   . ALA   B 2 174 ? -27.987 -30.006  -48.798 1.00 74.05  ? 175  ALA   B C   1 
ATOM   6239 O  O   . ALA   B 2 174 ? -27.515 -28.968  -48.309 1.00 72.77  ? 175  ALA   B O   1 
ATOM   6240 C  CB  . ALA   B 2 174 ? -30.155 -30.534  -47.676 1.00 73.38  ? 175  ALA   B CB  1 
ATOM   6241 N  N   . SER   B 2 175 ? -27.899 -30.338  -50.090 1.00 78.79  ? 176  SER   B N   1 
ATOM   6242 C  CA  . SER   B 2 175 ? -27.372 -29.442  -51.155 1.00 79.42  ? 176  SER   B CA  1 
ATOM   6243 C  C   . SER   B 2 175 ? -28.194 -28.155  -51.170 1.00 73.88  ? 176  SER   B C   1 
ATOM   6244 O  O   . SER   B 2 175 ? -29.414 -28.203  -51.036 1.00 70.10  ? 176  SER   B O   1 
ATOM   6245 C  CB  . SER   B 2 175 ? -27.390 -30.112  -52.510 1.00 81.19  ? 176  SER   B CB  1 
ATOM   6246 O  OG  . SER   B 2 175 ? -26.489 -29.472  -53.405 1.00 83.67  ? 176  SER   B OG  1 
ATOM   6247 N  N   . PRO   B 2 176 ? -27.563 -26.967  -51.309 1.00 72.74  ? 177  PRO   B N   1 
ATOM   6248 C  CA  . PRO   B 2 176 ? -28.309 -25.714  -51.427 1.00 75.59  ? 177  PRO   B CA  1 
ATOM   6249 C  C   . PRO   B 2 176 ? -29.442 -25.782  -52.468 1.00 77.43  ? 177  PRO   B C   1 
ATOM   6250 O  O   . PRO   B 2 176 ? -30.572 -25.504  -52.100 1.00 71.18  ? 177  PRO   B O   1 
ATOM   6251 C  CB  . PRO   B 2 176 ? -27.252 -24.681  -51.853 1.00 73.89  ? 177  PRO   B CB  1 
ATOM   6252 C  CG  . PRO   B 2 176 ? -25.925 -25.259  -51.389 1.00 74.23  ? 177  PRO   B CG  1 
ATOM   6253 C  CD  . PRO   B 2 176 ? -26.108 -26.763  -51.334 1.00 73.52  ? 177  PRO   B CD  1 
ATOM   6254 N  N   . HIS   B 2 177 ? -29.130 -26.196  -53.706 1.00 78.46  ? 178  HIS   B N   1 
ATOM   6255 C  CA  . HIS   B 2 177 ? -29.993 -26.007  -54.907 1.00 79.44  ? 178  HIS   B CA  1 
ATOM   6256 C  C   . HIS   B 2 177 ? -30.318 -27.325  -55.628 1.00 82.58  ? 178  HIS   B C   1 
ATOM   6257 O  O   . HIS   B 2 177 ? -30.860 -27.244  -56.749 1.00 81.71  ? 178  HIS   B O   1 
ATOM   6258 C  CB  . HIS   B 2 177 ? -29.324 -25.010  -55.864 1.00 77.63  ? 178  HIS   B CB  1 
ATOM   6259 C  CG  . HIS   B 2 177 ? -29.018 -23.693  -55.232 1.00 75.82  ? 178  HIS   B CG  1 
ATOM   6260 N  ND1 . HIS   B 2 177 ? -29.997 -22.917  -54.635 1.00 70.02  ? 178  HIS   B ND1 1 
ATOM   6261 C  CD2 . HIS   B 2 177 ? -27.858 -23.011  -55.104 1.00 72.09  ? 178  HIS   B CD2 1 
ATOM   6262 C  CE1 . HIS   B 2 177 ? -29.448 -21.817  -54.160 1.00 71.26  ? 178  HIS   B CE1 1 
ATOM   6263 N  NE2 . HIS   B 2 177 ? -28.137 -21.849  -54.438 1.00 71.20  ? 178  HIS   B NE2 1 
ATOM   6264 N  N   . LYS   B 2 178 ? -30.033 -28.485  -55.025 1.00 84.95  ? 179  LYS   B N   1 
ATOM   6265 C  CA  . LYS   B 2 178 ? -30.278 -29.823  -55.634 1.00 85.95  ? 179  LYS   B CA  1 
ATOM   6266 C  C   . LYS   B 2 178 ? -31.041 -30.699  -54.637 1.00 88.38  ? 179  LYS   B C   1 
ATOM   6267 O  O   . LYS   B 2 178 ? -30.478 -31.003  -53.569 1.00 90.64  ? 179  LYS   B O   1 
ATOM   6268 C  CB  . LYS   B 2 178 ? -28.962 -30.508  -56.010 1.00 88.10  ? 179  LYS   B CB  1 
ATOM   6269 C  CG  . LYS   B 2 178 ? -28.027 -29.723  -56.918 1.00 90.53  ? 179  LYS   B CG  1 
ATOM   6270 C  CD  . LYS   B 2 178 ? -26.621 -30.288  -56.906 1.00 94.61  ? 179  LYS   B CD  1 
ATOM   6271 C  CE  . LYS   B 2 178 ? -25.773 -29.847  -58.079 1.00 97.53  ? 179  LYS   B CE  1 
ATOM   6272 N  NZ  . LYS   B 2 178 ? -24.527 -30.644  -58.166 1.00 97.42  ? 179  LYS   B NZ  1 
ATOM   6273 N  N   . ASP   B 2 179 ? -32.258 -31.117  -54.993 1.00 91.58  ? 180  ASP   B N   1 
ATOM   6274 C  CA  . ASP   B 2 179 ? -33.206 -31.810  -54.078 1.00 94.60  ? 180  ASP   B CA  1 
ATOM   6275 C  C   . ASP   B 2 179 ? -32.798 -33.279  -53.881 1.00 91.28  ? 180  ASP   B C   1 
ATOM   6276 O  O   . ASP   B 2 179 ? -33.406 -33.940  -53.010 1.00 92.28  ? 180  ASP   B O   1 
ATOM   6277 C  CB  . ASP   B 2 179 ? -34.641 -31.709  -54.602 1.00 100.02 ? 180  ASP   B CB  1 
ATOM   6278 C  CG  . ASP   B 2 179 ? -35.690 -31.888  -53.519 1.00 102.90 ? 180  ASP   B CG  1 
ATOM   6279 O  OD1 . ASP   B 2 179 ? -35.692 -31.077  -52.571 1.00 101.83 ? 180  ASP   B OD1 1 
ATOM   6280 O  OD2 . ASP   B 2 179 ? -36.487 -32.843  -53.626 1.00 108.88 ? 180  ASP   B OD2 1 
ATOM   6281 N  N   . SER   B 2 180 ? -31.822 -33.769  -54.653 1.00 86.77  ? 181  SER   B N   1 
ATOM   6282 C  CA  . SER   B 2 180 ? -31.373 -35.188  -54.674 1.00 82.28  ? 181  SER   B CA  1 
ATOM   6283 C  C   . SER   B 2 180 ? -30.001 -35.350  -54.004 1.00 76.15  ? 181  SER   B C   1 
ATOM   6284 O  O   . SER   B 2 180 ? -29.643 -36.497  -53.691 1.00 77.38  ? 181  SER   B O   1 
ATOM   6285 C  CB  . SER   B 2 180 ? -31.355 -35.715  -56.091 1.00 81.73  ? 181  SER   B CB  1 
ATOM   6286 O  OG  . SER   B 2 180 ? -30.303 -35.125  -56.844 1.00 81.12  ? 181  SER   B OG  1 
ATOM   6287 N  N   . VAL   B 2 181 ? -29.259 -34.259  -53.792 1.00 72.55  ? 182  VAL   B N   1 
ATOM   6288 C  CA  . VAL   B 2 181 ? -27.854 -34.295  -53.285 1.00 72.85  ? 182  VAL   B CA  1 
ATOM   6289 C  C   . VAL   B 2 181 ? -27.828 -33.844  -51.819 1.00 76.87  ? 182  VAL   B C   1 
ATOM   6290 O  O   . VAL   B 2 181 ? -28.608 -32.935  -51.456 1.00 79.08  ? 182  VAL   B O   1 
ATOM   6291 C  CB  . VAL   B 2 181 ? -26.920 -33.434  -54.159 1.00 69.27  ? 182  VAL   B CB  1 
ATOM   6292 C  CG1 . VAL   B 2 181 ? -25.559 -33.220  -53.514 1.00 68.39  ? 182  VAL   B CG1 1 
ATOM   6293 C  CG2 . VAL   B 2 181 ? -26.757 -34.027  -55.550 1.00 71.07  ? 182  VAL   B CG2 1 
ATOM   6294 N  N   . PHE   B 2 182 ? -26.956 -34.468  -51.018 1.00 75.62  ? 183  PHE   B N   1 
ATOM   6295 C  CA  . PHE   B 2 182 ? -26.607 -34.053  -49.634 1.00 73.36  ? 183  PHE   B CA  1 
ATOM   6296 C  C   . PHE   B 2 182 ? -25.331 -34.767  -49.181 1.00 73.75  ? 183  PHE   B C   1 
ATOM   6297 O  O   . PHE   B 2 182 ? -25.039 -35.887  -49.655 1.00 71.01  ? 183  PHE   B O   1 
ATOM   6298 C  CB  . PHE   B 2 182 ? -27.750 -34.352  -48.665 1.00 69.10  ? 183  PHE   B CB  1 
ATOM   6299 C  CG  . PHE   B 2 182 ? -28.146 -35.802  -48.592 1.00 68.90  ? 183  PHE   B CG  1 
ATOM   6300 C  CD1 . PHE   B 2 182 ? -29.106 -36.310  -49.452 1.00 69.82  ? 183  PHE   B CD1 1 
ATOM   6301 C  CD2 . PHE   B 2 182 ? -27.570 -36.652  -47.660 1.00 69.13  ? 183  PHE   B CD2 1 
ATOM   6302 C  CE1 . PHE   B 2 182 ? -29.479 -37.644  -49.385 1.00 71.78  ? 183  PHE   B CE1 1 
ATOM   6303 C  CE2 . PHE   B 2 182 ? -27.946 -37.985  -47.592 1.00 69.29  ? 183  PHE   B CE2 1 
ATOM   6304 C  CZ  . PHE   B 2 182 ? -28.898 -38.479  -48.457 1.00 71.70  ? 183  PHE   B CZ  1 
ATOM   6305 N  N   . LEU   B 2 183 ? -24.593 -34.120  -48.281 1.00 72.00  ? 184  LEU   B N   1 
ATOM   6306 C  CA  . LEU   B 2 183 ? -23.408 -34.699  -47.605 1.00 72.47  ? 184  LEU   B CA  1 
ATOM   6307 C  C   . LEU   B 2 183 ? -23.871 -35.354  -46.306 1.00 72.23  ? 184  LEU   B C   1 
ATOM   6308 O  O   . LEU   B 2 183 ? -24.808 -34.827  -45.688 1.00 74.06  ? 184  LEU   B O   1 
ATOM   6309 C  CB  . LEU   B 2 183 ? -22.386 -33.594  -47.330 1.00 72.76  ? 184  LEU   B CB  1 
ATOM   6310 C  CG  . LEU   B 2 183 ? -21.733 -32.995  -48.573 1.00 75.14  ? 184  LEU   B CG  1 
ATOM   6311 C  CD1 . LEU   B 2 183 ? -21.085 -31.657  -48.256 1.00 74.79  ? 184  LEU   B CD1 1 
ATOM   6312 C  CD2 . LEU   B 2 183 ? -20.717 -33.954  -49.179 1.00 75.24  ? 184  LEU   B CD2 1 
ATOM   6313 N  N   . SER   B 2 184 ? -23.250 -36.477  -45.942 1.00 72.37  ? 185  SER   B N   1 
ATOM   6314 C  CA  . SER   B 2 184 ? -23.288 -37.073  -44.583 1.00 69.39  ? 185  SER   B CA  1 
ATOM   6315 C  C   . SER   B 2 184 ? -21.850 -37.328  -44.121 1.00 68.40  ? 185  SER   B C   1 
ATOM   6316 O  O   . SER   B 2 184 ? -20.941 -37.330  -44.980 1.00 65.42  ? 185  SER   B O   1 
ATOM   6317 C  CB  . SER   B 2 184 ? -24.104 -38.330  -44.557 1.00 68.00  ? 185  SER   B CB  1 
ATOM   6318 O  OG  . SER   B 2 184 ? -23.372 -39.410  -45.107 1.00 67.94  ? 185  SER   B OG  1 
ATOM   6319 N  N   . CYS   B 2 185 ? -21.652 -37.505  -42.814 1.00 68.30  ? 186  CYS   B N   1 
ATOM   6320 C  CA  . CYS   B 2 185 ? -20.352 -37.905  -42.216 1.00 68.53  ? 186  CYS   B CA  1 
ATOM   6321 C  C   . CYS   B 2 185 ? -20.596 -38.603  -40.871 1.00 68.85  ? 186  CYS   B C   1 
ATOM   6322 O  O   . CYS   B 2 185 ? -21.533 -38.207  -40.146 1.00 65.88  ? 186  CYS   B O   1 
ATOM   6323 C  CB  . CYS   B 2 185 ? -19.400 -36.718  -42.109 1.00 66.73  ? 186  CYS   B CB  1 
ATOM   6324 S  SG  . CYS   B 2 185 ? -19.793 -35.566  -40.770 1.00 69.19  ? 186  CYS   B SG  1 
ATOM   6325 N  N   . SER   B 2 186 ? -19.775 -39.617  -40.582 1.00 69.42  ? 187  SER   B N   1 
ATOM   6326 C  CA  . SER   B 2 186 ? -19.982 -40.649  -39.533 1.00 67.04  ? 187  SER   B CA  1 
ATOM   6327 C  C   . SER   B 2 186 ? -18.662 -40.918  -38.809 1.00 67.74  ? 187  SER   B C   1 
ATOM   6328 O  O   . SER   B 2 186 ? -17.600 -40.512  -39.332 1.00 66.54  ? 187  SER   B O   1 
ATOM   6329 C  CB  . SER   B 2 186 ? -20.531 -41.915  -40.144 1.00 64.67  ? 187  SER   B CB  1 
ATOM   6330 O  OG  . SER   B 2 186 ? -20.596 -42.971  -39.194 1.00 60.72  ? 187  SER   B OG  1 
ATOM   6331 N  N   . GLU   B 2 187 ? -18.738 -41.609  -37.668 1.00 68.06  ? 188  GLU   B N   1 
ATOM   6332 C  CA  . GLU   B 2 187 ? -17.565 -41.995  -36.840 1.00 70.26  ? 188  GLU   B CA  1 
ATOM   6333 C  C   . GLU   B 2 187 ? -16.833 -43.186  -37.483 1.00 67.59  ? 188  GLU   B C   1 
ATOM   6334 O  O   . GLU   B 2 187 ? -15.761 -43.559  -36.971 1.00 71.81  ? 188  GLU   B O   1 
ATOM   6335 C  CB  . GLU   B 2 187 ? -18.026 -42.262  -35.407 1.00 73.23  ? 188  GLU   B CB  1 
ATOM   6336 C  CG  . GLU   B 2 187 ? -18.536 -41.004  -34.729 1.00 76.04  ? 188  GLU   B CG  1 
ATOM   6337 C  CD  . GLU   B 2 187 ? -18.891 -41.139  -33.261 1.00 74.97  ? 188  GLU   B CD  1 
ATOM   6338 O  OE1 . GLU   B 2 187 ? -19.181 -42.271  -32.826 1.00 81.20  ? 188  GLU   B OE1 1 
ATOM   6339 O  OE2 . GLU   B 2 187 ? -18.883 -40.105  -32.564 1.00 70.66  ? 188  GLU   B OE2 1 
ATOM   6340 N  N   . ASP   B 2 188 ? -17.370 -43.738  -38.578 1.00 61.16  ? 189  ASP   B N   1 
ATOM   6341 C  CA  . ASP   B 2 188 ? -16.677 -44.732  -39.439 1.00 61.33  ? 189  ASP   B CA  1 
ATOM   6342 C  C   . ASP   B 2 188 ? -15.657 -44.015  -40.335 1.00 60.44  ? 189  ASP   B C   1 
ATOM   6343 O  O   . ASP   B 2 188 ? -15.063 -44.685  -41.199 1.00 60.10  ? 189  ASP   B O   1 
ATOM   6344 C  CB  . ASP   B 2 188 ? -17.679 -45.550  -40.259 1.00 62.36  ? 189  ASP   B CB  1 
ATOM   6345 C  CG  . ASP   B 2 188 ? -18.376 -44.791  -41.378 1.00 60.93  ? 189  ASP   B CG  1 
ATOM   6346 O  OD1 . ASP   B 2 188 ? -18.024 -43.620  -41.611 1.00 56.26  ? 189  ASP   B OD1 1 
ATOM   6347 O  OD2 . ASP   B 2 188 ? -19.271 -45.389  -42.009 1.00 62.93  ? 189  ASP   B OD2 1 
ATOM   6348 N  N   . ASN   B 2 189 ? -15.508 -42.697  -40.165 1.00 59.78  ? 190  ASN   B N   1 
ATOM   6349 C  CA  . ASN   B 2 189 ? -14.463 -41.859  -40.808 1.00 61.57  ? 190  ASN   B CA  1 
ATOM   6350 C  C   . ASN   B 2 189 ? -14.773 -41.665  -42.302 1.00 63.70  ? 190  ASN   B C   1 
ATOM   6351 O  O   . ASN   B 2 189 ? -13.846 -41.288  -43.055 1.00 66.92  ? 190  ASN   B O   1 
ATOM   6352 C  CB  . ASN   B 2 189 ? -13.066 -42.444  -40.582 1.00 59.35  ? 190  ASN   B CB  1 
ATOM   6353 C  CG  . ASN   B 2 189 ? -11.976 -41.398  -40.673 1.00 60.38  ? 190  ASN   B CG  1 
ATOM   6354 O  OD1 . ASN   B 2 189 ? -12.242 -40.202  -40.582 1.00 59.12  ? 190  ASN   B OD1 1 
ATOM   6355 N  ND2 . ASN   B 2 189 ? -10.743 -41.836  -40.859 1.00 63.72  ? 190  ASN   B ND2 1 
ATOM   6356 N  N   . ARG   B 2 190 ? -16.029 -41.869  -42.712 1.00 63.13  ? 191  ARG   B N   1 
ATOM   6357 C  CA  . ARG   B 2 190 ? -16.497 -41.623  -44.102 1.00 66.29  ? 191  ARG   B CA  1 
ATOM   6358 C  C   . ARG   B 2 190 ? -17.192 -40.260  -44.181 1.00 69.72  ? 191  ARG   B C   1 
ATOM   6359 O  O   . ARG   B 2 190 ? -17.980 -39.932  -43.270 1.00 67.64  ? 191  ARG   B O   1 
ATOM   6360 C  CB  . ARG   B 2 190 ? -17.468 -42.711  -44.564 1.00 67.06  ? 191  ARG   B CB  1 
ATOM   6361 C  CG  . ARG   B 2 190 ? -16.835 -44.084  -44.724 1.00 67.72  ? 191  ARG   B CG  1 
ATOM   6362 C  CD  . ARG   B 2 190 ? -17.838 -45.085  -45.254 1.00 69.70  ? 191  ARG   B CD  1 
ATOM   6363 N  NE  . ARG   B 2 190 ? -17.197 -46.330  -45.651 1.00 72.25  ? 191  ARG   B NE  1 
ATOM   6364 C  CZ  . ARG   B 2 190 ? -17.314 -47.498  -45.024 1.00 71.90  ? 191  ARG   B CZ  1 
ATOM   6365 N  NH1 . ARG   B 2 190 ? -18.061 -47.616  -43.938 1.00 69.38  ? 191  ARG   B NH1 1 
ATOM   6366 N  NH2 . ARG   B 2 190 ? -16.678 -48.555  -45.499 1.00 75.45  ? 191  ARG   B NH2 1 
ATOM   6367 N  N   . ILE   B 2 191 ? -16.884 -39.497  -45.230 1.00 73.21  ? 192  ILE   B N   1 
ATOM   6368 C  CA  . ILE   B 2 191 ? -17.742 -38.394  -45.751 1.00 73.00  ? 192  ILE   B CA  1 
ATOM   6369 C  C   . ILE   B 2 191 ? -18.375 -38.901  -47.047 1.00 72.14  ? 192  ILE   B C   1 
ATOM   6370 O  O   . ILE   B 2 191 ? -17.623 -39.090  -48.024 1.00 74.60  ? 192  ILE   B O   1 
ATOM   6371 C  CB  . ILE   B 2 191 ? -16.935 -37.102  -45.970 1.00 73.86  ? 192  ILE   B CB  1 
ATOM   6372 C  CG1 . ILE   B 2 191 ? -16.186 -36.681  -44.703 1.00 73.06  ? 192  ILE   B CG1 1 
ATOM   6373 C  CG2 . ILE   B 2 191 ? -17.844 -35.997  -46.486 1.00 76.37  ? 192  ILE   B CG2 1 
ATOM   6374 C  CD1 . ILE   B 2 191 ? -15.217 -35.544  -44.910 1.00 74.24  ? 192  ILE   B CD1 1 
ATOM   6375 N  N   . LEU   B 2 192 ? -19.688 -39.146  -47.031 1.00 71.02  ? 193  LEU   B N   1 
ATOM   6376 C  CA  . LEU   B 2 192 ? -20.474 -39.617  -48.201 1.00 72.79  ? 193  LEU   B CA  1 
ATOM   6377 C  C   . LEU   B 2 192 ? -21.124 -38.416  -48.900 1.00 76.27  ? 193  LEU   B C   1 
ATOM   6378 O  O   . LEU   B 2 192 ? -21.909 -37.701  -48.241 1.00 73.43  ? 193  LEU   B O   1 
ATOM   6379 C  CB  . LEU   B 2 192 ? -21.546 -40.609  -47.735 1.00 71.42  ? 193  LEU   B CB  1 
ATOM   6380 C  CG  . LEU   B 2 192 ? -21.040 -41.911  -47.117 1.00 68.03  ? 193  LEU   B CG  1 
ATOM   6381 C  CD1 . LEU   B 2 192 ? -22.189 -42.891  -46.928 1.00 66.98  ? 193  LEU   B CD1 1 
ATOM   6382 C  CD2 . LEU   B 2 192 ? -19.939 -42.539  -47.960 1.00 66.20  ? 193  LEU   B CD2 1 
ATOM   6383 N  N   . LEU   B 2 193 ? -20.795 -38.208  -50.180 1.00 77.64  ? 194  LEU   B N   1 
ATOM   6384 C  CA  . LEU   B 2 193 ? -21.551 -37.323  -51.107 1.00 75.76  ? 194  LEU   B CA  1 
ATOM   6385 C  C   . LEU   B 2 193 ? -22.686 -38.145  -51.718 1.00 71.46  ? 194  LEU   B C   1 
ATOM   6386 O  O   . LEU   B 2 193 ? -22.382 -39.061  -52.496 1.00 73.62  ? 194  LEU   B O   1 
ATOM   6387 C  CB  . LEU   B 2 193 ? -20.617 -36.781  -52.192 1.00 77.56  ? 194  LEU   B CB  1 
ATOM   6388 C  CG  . LEU   B 2 193 ? -21.301 -36.079  -53.366 1.00 78.92  ? 194  LEU   B CG  1 
ATOM   6389 C  CD1 . LEU   B 2 193 ? -22.259 -35.000  -52.881 1.00 79.76  ? 194  LEU   B CD1 1 
ATOM   6390 C  CD2 . LEU   B 2 193 ? -20.269 -35.490  -54.315 1.00 75.95  ? 194  LEU   B CD2 1 
ATOM   6391 N  N   . TRP   B 2 194 ? -23.934 -37.840  -51.354 1.00 70.62  ? 195  TRP   B N   1 
ATOM   6392 C  CA  . TRP   B 2 194 ? -25.133 -38.580  -51.824 1.00 70.02  ? 195  TRP   B CA  1 
ATOM   6393 C  C   . TRP   B 2 194 ? -25.664 -37.933  -53.104 1.00 70.25  ? 195  TRP   B C   1 
ATOM   6394 O  O   . TRP   B 2 194 ? -25.323 -36.766  -53.372 1.00 68.90  ? 195  TRP   B O   1 
ATOM   6395 C  CB  . TRP   B 2 194 ? -26.210 -38.640  -50.738 1.00 70.00  ? 195  TRP   B CB  1 
ATOM   6396 C  CG  . TRP   B 2 194 ? -25.822 -39.457  -49.546 1.00 70.27  ? 195  TRP   B CG  1 
ATOM   6397 C  CD1 . TRP   B 2 194 ? -24.951 -39.112  -48.553 1.00 70.61  ? 195  TRP   B CD1 1 
ATOM   6398 C  CD2 . TRP   B 2 194 ? -26.310 -40.766  -49.209 1.00 68.65  ? 195  TRP   B CD2 1 
ATOM   6399 N  NE1 . TRP   B 2 194 ? -24.864 -40.116  -47.626 1.00 69.21  ? 195  TRP   B NE1 1 
ATOM   6400 C  CE2 . TRP   B 2 194 ? -25.685 -41.144  -48.002 1.00 67.87  ? 195  TRP   B CE2 1 
ATOM   6401 C  CE3 . TRP   B 2 194 ? -27.207 -41.654  -49.811 1.00 70.75  ? 195  TRP   B CE3 1 
ATOM   6402 C  CZ2 . TRP   B 2 194 ? -25.928 -42.371  -47.390 1.00 68.31  ? 195  TRP   B CZ2 1 
ATOM   6403 C  CZ3 . TRP   B 2 194 ? -27.449 -42.867  -49.205 1.00 72.90  ? 195  TRP   B CZ3 1 
ATOM   6404 C  CH2 . TRP   B 2 194 ? -26.820 -43.215  -48.008 1.00 71.40  ? 195  TRP   B CH2 1 
ATOM   6405 N  N   . ASP   B 2 195 ? -26.422 -38.713  -53.874 1.00 69.87  ? 196  ASP   B N   1 
ATOM   6406 C  CA  . ASP   B 2 195 ? -27.213 -38.286  -55.055 1.00 68.94  ? 196  ASP   B CA  1 
ATOM   6407 C  C   . ASP   B 2 195 ? -28.243 -39.389  -55.309 1.00 67.45  ? 196  ASP   B C   1 
ATOM   6408 O  O   . ASP   B 2 195 ? -27.867 -40.409  -55.911 1.00 64.14  ? 196  ASP   B O   1 
ATOM   6409 C  CB  . ASP   B 2 195 ? -26.324 -38.004  -56.271 1.00 70.41  ? 196  ASP   B CB  1 
ATOM   6410 C  CG  . ASP   B 2 195 ? -27.028 -37.244  -57.393 1.00 71.49  ? 196  ASP   B CG  1 
ATOM   6411 O  OD1 . ASP   B 2 195 ? -28.265 -37.405  -57.537 1.00 64.87  ? 196  ASP   B OD1 1 
ATOM   6412 O  OD2 . ASP   B 2 195 ? -26.335 -36.494  -58.118 1.00 65.32  ? 196  ASP   B OD2 1 
ATOM   6413 N  N   . THR   B 2 196 ? -29.481 -39.195  -54.838 1.00 68.70  ? 197  THR   B N   1 
ATOM   6414 C  CA  . THR   B 2 196 ? -30.569 -40.211  -54.835 1.00 71.38  ? 197  THR   B CA  1 
ATOM   6415 C  C   . THR   B 2 196 ? -30.979 -40.570  -56.273 1.00 72.57  ? 197  THR   B C   1 
ATOM   6416 O  O   . THR   B 2 196 ? -31.862 -41.441  -56.423 1.00 72.29  ? 197  THR   B O   1 
ATOM   6417 C  CB  . THR   B 2 196 ? -31.757 -39.745  -53.978 1.00 76.96  ? 197  THR   B CB  1 
ATOM   6418 O  OG1 . THR   B 2 196 ? -32.068 -38.386  -54.287 1.00 76.37  ? 197  THR   B OG1 1 
ATOM   6419 C  CG2 . THR   B 2 196 ? -31.488 -39.871  -52.492 1.00 78.61  ? 197  THR   B CG2 1 
ATOM   6420 N  N   . ARG   B 2 197 ? -30.355 -39.956  -57.288 1.00 72.96  ? 198  ARG   B N   1 
ATOM   6421 C  CA  . ARG   B 2 197 ? -30.608 -40.241  -58.729 1.00 75.24  ? 198  ARG   B CA  1 
ATOM   6422 C  C   . ARG   B 2 197 ? -29.810 -41.479  -59.165 1.00 76.20  ? 198  ARG   B C   1 
ATOM   6423 O  O   . ARG   B 2 197 ? -30.334 -42.243  -60.005 1.00 75.46  ? 198  ARG   B O   1 
ATOM   6424 C  CB  . ARG   B 2 197 ? -30.258 -39.025  -59.594 1.00 76.64  ? 198  ARG   B CB  1 
ATOM   6425 C  CG  . ARG   B 2 197 ? -31.210 -37.847  -59.426 1.00 72.40  ? 198  ARG   B CG  1 
ATOM   6426 C  CD  . ARG   B 2 197 ? -30.821 -36.592  -60.193 1.00 71.16  ? 198  ARG   B CD  1 
ATOM   6427 N  NE  . ARG   B 2 197 ? -29.534 -36.015  -59.806 1.00 69.52  ? 198  ARG   B NE  1 
ATOM   6428 C  CZ  . ARG   B 2 197 ? -29.129 -34.771  -60.084 1.00 72.33  ? 198  ARG   B CZ  1 
ATOM   6429 N  NH1 . ARG   B 2 197 ? -29.911 -33.936  -60.750 1.00 77.51  ? 198  ARG   B NH1 1 
ATOM   6430 N  NH2 . ARG   B 2 197 ? -27.938 -34.357  -59.687 1.00 69.65  ? 198  ARG   B NH2 1 
ATOM   6431 N  N   . CYS   B 2 198 ? -28.595 -41.662  -58.627 1.00 73.93  ? 199  CYS   B N   1 
ATOM   6432 C  CA  . CYS   B 2 198 ? -27.708 -42.833  -58.882 1.00 71.92  ? 199  CYS   B CA  1 
ATOM   6433 C  C   . CYS   B 2 198 ? -28.274 -44.079  -58.204 1.00 73.75  ? 199  CYS   B C   1 
ATOM   6434 O  O   . CYS   B 2 198 ? -28.718 -44.004  -57.058 1.00 69.78  ? 199  CYS   B O   1 
ATOM   6435 C  CB  . CYS   B 2 198 ? -26.298 -42.583  -58.365 1.00 67.55  ? 199  CYS   B CB  1 
ATOM   6436 S  SG  . CYS   B 2 198 ? -25.587 -41.014  -58.926 1.00 65.97  ? 199  CYS   B SG  1 
ATOM   6437 N  N   . PRO   B 2 199 ? -28.268 -45.259  -58.875 1.00 81.38  ? 200  PRO   B N   1 
ATOM   6438 C  CA  . PRO   B 2 199 ? -28.824 -46.485  -58.293 1.00 83.77  ? 200  PRO   B CA  1 
ATOM   6439 C  C   . PRO   B 2 199 ? -28.036 -46.964  -57.060 1.00 82.30  ? 200  PRO   B C   1 
ATOM   6440 O  O   . PRO   B 2 199 ? -28.620 -47.642  -56.232 1.00 79.37  ? 200  PRO   B O   1 
ATOM   6441 C  CB  . PRO   B 2 199 ? -28.776 -47.509  -59.442 1.00 83.53  ? 200  PRO   B CB  1 
ATOM   6442 C  CG  . PRO   B 2 199 ? -27.706 -46.985  -60.384 1.00 84.40  ? 200  PRO   B CG  1 
ATOM   6443 C  CD  . PRO   B 2 199 ? -27.725 -45.477  -60.226 1.00 83.14  ? 200  PRO   B CD  1 
ATOM   6444 N  N   . LYS   B 2 200 ? -26.747 -46.608  -56.975 1.00 80.02  ? 201  LYS   B N   1 
ATOM   6445 C  CA  . LYS   B 2 200 ? -25.929 -46.663  -55.732 1.00 76.69  ? 201  LYS   B CA  1 
ATOM   6446 C  C   . LYS   B 2 200 ? -25.746 -45.228  -55.243 1.00 72.82  ? 201  LYS   B C   1 
ATOM   6447 O  O   . LYS   B 2 200 ? -24.773 -44.559  -55.592 1.00 70.70  ? 201  LYS   B O   1 
ATOM   6448 C  CB  . LYS   B 2 200 ? -24.618 -47.412  -55.988 1.00 81.15  ? 201  LYS   B CB  1 
ATOM   6449 C  CG  . LYS   B 2 200 ? -24.794 -48.902  -56.252 1.00 85.92  ? 201  LYS   B CG  1 
ATOM   6450 C  CD  . LYS   B 2 200 ? -23.555 -49.735  -56.007 1.00 88.73  ? 201  LYS   B CD  1 
ATOM   6451 C  CE  . LYS   B 2 200 ? -23.840 -51.221  -56.064 1.00 89.32  ? 201  LYS   B CE  1 
ATOM   6452 N  NZ  . LYS   B 2 200 ? -22.619 -52.024  -55.818 1.00 90.32  ? 201  LYS   B NZ  1 
ATOM   6453 N  N   . PRO   B 2 201 ? -26.709 -44.707  -54.445 1.00 68.94  ? 202  PRO   B N   1 
ATOM   6454 C  CA  . PRO   B 2 201 ? -26.819 -43.270  -54.176 1.00 68.23  ? 202  PRO   B CA  1 
ATOM   6455 C  C   . PRO   B 2 201 ? -25.590 -42.559  -53.584 1.00 69.11  ? 202  PRO   B C   1 
ATOM   6456 O  O   . PRO   B 2 201 ? -25.368 -41.412  -53.933 1.00 70.07  ? 202  PRO   B O   1 
ATOM   6457 C  CB  . PRO   B 2 201 ? -27.983 -43.163  -53.174 1.00 69.07  ? 202  PRO   B CB  1 
ATOM   6458 C  CG  . PRO   B 2 201 ? -28.223 -44.576  -52.676 1.00 69.06  ? 202  PRO   B CG  1 
ATOM   6459 C  CD  . PRO   B 2 201 ? -27.789 -45.476  -53.810 1.00 67.50  ? 202  PRO   B CD  1 
ATOM   6460 N  N   . ALA   B 2 202 ? -24.834 -43.222  -52.704 1.00 70.11  ? 203  ALA   B N   1 
ATOM   6461 C  CA  . ALA   B 2 202 ? -23.715 -42.609  -51.947 1.00 69.62  ? 203  ALA   B CA  1 
ATOM   6462 C  C   . ALA   B 2 202 ? -22.389 -42.783  -52.697 1.00 64.42  ? 203  ALA   B C   1 
ATOM   6463 O  O   . ALA   B 2 202 ? -22.265 -43.728  -53.491 1.00 63.19  ? 203  ALA   B O   1 
ATOM   6464 C  CB  . ALA   B 2 202 ? -23.639 -43.205  -50.562 1.00 73.95  ? 203  ALA   B CB  1 
ATOM   6465 N  N   . SER   B 2 203 ? -21.435 -41.890  -52.436 1.00 64.88  ? 204  SER   B N   1 
ATOM   6466 C  CA  . SER   B 2 203 ? -20.044 -41.926  -52.957 1.00 68.92  ? 204  SER   B CA  1 
ATOM   6467 C  C   . SER   B 2 203 ? -19.090 -41.427  -51.865 1.00 71.87  ? 204  SER   B C   1 
ATOM   6468 O  O   . SER   B 2 203 ? -19.318 -40.320  -51.340 1.00 70.53  ? 204  SER   B O   1 
ATOM   6469 C  CB  . SER   B 2 203 ? -19.917 -41.113  -54.224 1.00 70.15  ? 204  SER   B CB  1 
ATOM   6470 O  OG  . SER   B 2 203 ? -18.561 -40.775  -54.485 1.00 73.25  ? 204  SER   B OG  1 
ATOM   6471 N  N   . GLN   B 2 204 ? -18.075 -42.225  -51.527 1.00 75.74  ? 205  GLN   B N   1 
ATOM   6472 C  CA  . GLN   B 2 204 ? -17.058 -41.890  -50.496 1.00 78.13  ? 205  GLN   B CA  1 
ATOM   6473 C  C   . GLN   B 2 204 ? -16.092 -40.867  -51.102 1.00 78.87  ? 205  GLN   B C   1 
ATOM   6474 O  O   . GLN   B 2 204 ? -15.800 -40.993  -52.301 1.00 83.98  ? 205  GLN   B O   1 
ATOM   6475 C  CB  . GLN   B 2 204 ? -16.351 -43.166  -50.033 1.00 78.14  ? 205  GLN   B CB  1 
ATOM   6476 C  CG  . GLN   B 2 204 ? -15.626 -43.023  -48.703 1.00 79.92  ? 205  GLN   B CG  1 
ATOM   6477 C  CD  . GLN   B 2 204 ? -15.166 -44.347  -48.138 1.00 81.26  ? 205  GLN   B CD  1 
ATOM   6478 O  OE1 . GLN   B 2 204 ? -15.794 -45.388  -48.333 1.00 80.71  ? 205  GLN   B OE1 1 
ATOM   6479 N  NE2 . GLN   B 2 204 ? -14.060 -44.314  -47.412 1.00 79.38  ? 205  GLN   B NE2 1 
ATOM   6480 N  N   . ILE   B 2 205 ? -15.644 -39.884  -50.317 1.00 83.03  ? 206  ILE   B N   1 
ATOM   6481 C  CA  . ILE   B 2 205 ? -14.690 -38.822  -50.764 1.00 89.92  ? 206  ILE   B CA  1 
ATOM   6482 C  C   . ILE   B 2 205 ? -13.730 -38.495  -49.613 1.00 97.09  ? 206  ILE   B C   1 
ATOM   6483 O  O   . ILE   B 2 205 ? -14.185 -38.468  -48.453 1.00 101.27 ? 206  ILE   B O   1 
ATOM   6484 C  CB  . ILE   B 2 205 ? -15.448 -37.578  -51.275 1.00 91.11  ? 206  ILE   B CB  1 
ATOM   6485 C  CG1 . ILE   B 2 205 ? -16.508 -37.094  -50.281 1.00 87.91  ? 206  ILE   B CG1 1 
ATOM   6486 C  CG2 . ILE   B 2 205 ? -16.051 -37.849  -52.648 1.00 92.59  ? 206  ILE   B CG2 1 
ATOM   6487 C  CD1 . ILE   B 2 205 ? -17.154 -35.784  -50.660 1.00 85.46  ? 206  ILE   B CD1 1 
ATOM   6488 N  N   . GLY   B 2 206 ? -12.452 -38.264  -49.934 1.00 105.25 ? 207  GLY   B N   1 
ATOM   6489 C  CA  . GLY   B 2 206 ? -11.349 -38.110  -48.962 1.00 112.12 ? 207  GLY   B CA  1 
ATOM   6490 C  C   . GLY   B 2 206 ? -10.552 -39.399  -48.830 1.00 120.59 ? 207  GLY   B C   1 
ATOM   6491 O  O   . GLY   B 2 206 ? -11.179 -40.455  -48.612 1.00 120.34 ? 207  GLY   B O   1 
ATOM   6492 N  N   . CYS   B 2 207 ? -9.220  -39.322  -48.941 1.00 129.62 ? 208  CYS   B N   1 
ATOM   6493 C  CA  . CYS   B 2 207 ? -8.316  -40.486  -49.170 1.00 135.64 ? 208  CYS   B CA  1 
ATOM   6494 C  C   . CYS   B 2 207 ? -7.793  -41.069  -47.849 1.00 140.43 ? 208  CYS   B C   1 
ATOM   6495 O  O   . CYS   B 2 207 ? -7.997  -42.282  -47.635 1.00 141.36 ? 208  CYS   B O   1 
ATOM   6496 C  CB  . CYS   B 2 207 ? -7.150  -40.106  -50.076 1.00 134.37 ? 208  CYS   B CB  1 
ATOM   6497 S  SG  . CYS   B 2 207 ? -6.095  -38.798  -49.396 1.00 136.28 ? 208  CYS   B SG  1 
ATOM   6498 N  N   . SER   B 2 208 ? -7.139  -40.256  -47.008 1.00 143.57 ? 209  SER   B N   1 
ATOM   6499 C  CA  . SER   B 2 208 ? -6.380  -40.706  -45.806 1.00 139.87 ? 209  SER   B CA  1 
ATOM   6500 C  C   . SER   B 2 208 ? -7.280  -41.534  -44.880 1.00 137.39 ? 209  SER   B C   1 
ATOM   6501 O  O   . SER   B 2 208 ? -8.288  -40.990  -44.390 1.00 128.25 ? 209  SER   B O   1 
ATOM   6502 C  CB  . SER   B 2 208 ? -5.756  -39.544  -45.064 1.00 138.94 ? 209  SER   B CB  1 
ATOM   6503 O  OG  . SER   B 2 208 ? -6.746  -38.718  -44.471 1.00 137.59 ? 209  SER   B OG  1 
ATOM   6504 N  N   . ALA   B 2 209 ? -6.915  -42.803  -44.665 1.00 142.19 ? 210  ALA   B N   1 
ATOM   6505 C  CA  . ALA   B 2 209 ? -7.529  -43.729  -43.684 1.00 147.07 ? 210  ALA   B CA  1 
ATOM   6506 C  C   . ALA   B 2 209 ? -7.254  -43.257  -42.254 1.00 152.47 ? 210  ALA   B C   1 
ATOM   6507 O  O   . ALA   B 2 209 ? -8.125  -43.396  -41.397 1.00 151.09 ? 210  ALA   B O   1 
ATOM   6508 C  CB  . ALA   B 2 209 ? -7.024  -45.136  -43.910 1.00 146.52 ? 210  ALA   B CB  1 
ATOM   6509 N  N   . PRO   B 2 210 ? -6.054  -42.707  -41.931 1.00 159.24 ? 211  PRO   B N   1 
ATOM   6510 C  CA  . PRO   B 2 210 ? -5.775  -42.201  -40.583 1.00 156.02 ? 211  PRO   B CA  1 
ATOM   6511 C  C   . PRO   B 2 210 ? -6.185  -40.741  -40.311 1.00 148.79 ? 211  PRO   B C   1 
ATOM   6512 O  O   . PRO   B 2 210 ? -5.860  -40.245  -39.243 1.00 147.99 ? 211  PRO   B O   1 
ATOM   6513 C  CB  . PRO   B 2 210 ? -4.247  -42.349  -40.508 1.00 156.91 ? 211  PRO   B CB  1 
ATOM   6514 C  CG  . PRO   B 2 210 ? -3.789  -42.034  -41.915 1.00 159.04 ? 211  PRO   B CG  1 
ATOM   6515 C  CD  . PRO   B 2 210 ? -4.877  -42.592  -42.811 1.00 160.69 ? 211  PRO   B CD  1 
ATOM   6516 N  N   . GLY   B 2 211 ? -6.872  -40.089  -41.260 1.00 134.35 ? 212  GLY   B N   1 
ATOM   6517 C  CA  . GLY   B 2 211 ? -7.444  -38.737  -41.091 1.00 121.03 ? 212  GLY   B CA  1 
ATOM   6518 C  C   . GLY   B 2 211 ? -8.496  -38.718  -39.993 1.00 111.53 ? 212  GLY   B C   1 
ATOM   6519 O  O   . GLY   B 2 211 ? -9.324  -39.648  -39.959 1.00 110.13 ? 212  GLY   B O   1 
ATOM   6520 N  N   . TYR   B 2 212 ? -8.471  -37.697  -39.128 1.00 98.53  ? 213  TYR   B N   1 
ATOM   6521 C  CA  . TYR   B 2 212 ? -9.325  -37.583  -37.914 1.00 86.40  ? 213  TYR   B CA  1 
ATOM   6522 C  C   . TYR   B 2 212 ? -10.805 -37.548  -38.310 1.00 81.86  ? 213  TYR   B C   1 
ATOM   6523 O  O   . TYR   B 2 212 ? -11.134 -37.009  -39.385 1.00 84.76  ? 213  TYR   B O   1 
ATOM   6524 C  CB  . TYR   B 2 212 ? -8.932  -36.355  -37.091 1.00 83.03  ? 213  TYR   B CB  1 
ATOM   6525 C  CG  . TYR   B 2 212 ? -7.563  -36.454  -36.468 1.00 81.65  ? 213  TYR   B CG  1 
ATOM   6526 C  CD1 . TYR   B 2 212 ? -7.297  -37.394  -35.485 1.00 80.79  ? 213  TYR   B CD1 1 
ATOM   6527 C  CD2 . TYR   B 2 212 ? -6.531  -35.619  -36.866 1.00 81.77  ? 213  TYR   B CD2 1 
ATOM   6528 C  CE1 . TYR   B 2 212 ? -6.042  -37.503  -34.909 1.00 80.14  ? 213  TYR   B CE1 1 
ATOM   6529 C  CE2 . TYR   B 2 212 ? -5.270  -35.713  -36.298 1.00 81.89  ? 213  TYR   B CE2 1 
ATOM   6530 C  CZ  . TYR   B 2 212 ? -5.025  -36.658  -35.317 1.00 81.58  ? 213  TYR   B CZ  1 
ATOM   6531 O  OH  . TYR   B 2 212 ? -3.786  -36.754  -34.756 1.00 82.94  ? 213  TYR   B OH  1 
ATOM   6532 N  N   . LEU   B 2 213 ? -11.663 -38.114  -37.455 1.00 78.71  ? 214  LEU   B N   1 
ATOM   6533 C  CA  . LEU   B 2 213 ? -13.115 -38.309  -37.714 1.00 73.12  ? 214  LEU   B CA  1 
ATOM   6534 C  C   . LEU   B 2 213 ? -13.749 -36.974  -38.082 1.00 73.10  ? 214  LEU   B C   1 
ATOM   6535 O  O   . LEU   B 2 213 ? -13.456 -35.961  -37.450 1.00 72.19  ? 214  LEU   B O   1 
ATOM   6536 C  CB  . LEU   B 2 213 ? -13.798 -38.886  -36.471 1.00 70.34  ? 214  LEU   B CB  1 
ATOM   6537 C  CG  . LEU   B 2 213 ? -13.321 -40.262  -36.010 1.00 68.39  ? 214  LEU   B CG  1 
ATOM   6538 C  CD1 . LEU   B 2 213 ? -14.245 -40.803  -34.928 1.00 69.02  ? 214  LEU   B CD1 1 
ATOM   6539 C  CD2 . LEU   B 2 213 ? -13.236 -41.239  -37.173 1.00 67.65  ? 214  LEU   B CD2 1 
ATOM   6540 N  N   . PRO   B 2 214 ? -14.639 -36.943  -39.101 1.00 72.59  ? 215  PRO   B N   1 
ATOM   6541 C  CA  . PRO   B 2 214 ? -15.340 -35.720  -39.489 1.00 69.72  ? 215  PRO   B CA  1 
ATOM   6542 C  C   . PRO   B 2 214 ? -16.540 -35.454  -38.568 1.00 69.95  ? 215  PRO   B C   1 
ATOM   6543 O  O   . PRO   B 2 214 ? -17.326 -36.364  -38.372 1.00 67.20  ? 215  PRO   B O   1 
ATOM   6544 C  CB  . PRO   B 2 214 ? -15.784 -36.046  -40.918 1.00 69.58  ? 215  PRO   B CB  1 
ATOM   6545 C  CG  . PRO   B 2 214 ? -16.065 -37.535  -40.874 1.00 70.90  ? 215  PRO   B CG  1 
ATOM   6546 C  CD  . PRO   B 2 214 ? -15.027 -38.097  -39.928 1.00 71.70  ? 215  PRO   B CD  1 
ATOM   6547 N  N   . THR   B 2 215 ? -16.656 -34.228  -38.043 1.00 73.06  ? 216  THR   B N   1 
ATOM   6548 C  CA  . THR   B 2 215 ? -17.643 -33.845  -36.994 1.00 73.25  ? 216  THR   B CA  1 
ATOM   6549 C  C   . THR   B 2 215 ? -18.684 -32.842  -37.514 1.00 73.63  ? 216  THR   B C   1 
ATOM   6550 O  O   . THR   B 2 215 ? -19.808 -32.887  -36.993 1.00 78.89  ? 216  THR   B O   1 
ATOM   6551 C  CB  . THR   B 2 215 ? -16.938 -33.339  -35.728 1.00 72.02  ? 216  THR   B CB  1 
ATOM   6552 O  OG1 . THR   B 2 215 ? -15.777 -32.592  -36.093 1.00 68.69  ? 216  THR   B OG1 1 
ATOM   6553 C  CG2 . THR   B 2 215 ? -16.548 -34.475  -34.808 1.00 73.77  ? 216  THR   B CG2 1 
ATOM   6554 N  N   . SER   B 2 216 ? -18.351 -31.973  -38.476 1.00 74.33  ? 217  SER   B N   1 
ATOM   6555 C  CA  . SER   B 2 216 ? -19.271 -30.918  -38.992 1.00 74.20  ? 217  SER   B CA  1 
ATOM   6556 C  C   . SER   B 2 216 ? -19.139 -30.758  -40.513 1.00 73.73  ? 217  SER   B C   1 
ATOM   6557 O  O   . SER   B 2 216 ? -18.046 -31.051  -41.047 1.00 70.95  ? 217  SER   B O   1 
ATOM   6558 C  CB  . SER   B 2 216 ? -19.035 -29.608  -38.283 1.00 72.96  ? 217  SER   B CB  1 
ATOM   6559 O  OG  . SER   B 2 216 ? -17.691 -29.175  -38.449 1.00 68.82  ? 217  SER   B OG  1 
ATOM   6560 N  N   . LEU   B 2 217 ? -20.222 -30.313  -41.168 1.00 71.53  ? 218  LEU   B N   1 
ATOM   6561 C  CA  . LEU   B 2 217 ? -20.313 -30.081  -42.639 1.00 73.11  ? 218  LEU   B CA  1 
ATOM   6562 C  C   . LEU   B 2 217 ? -21.083 -28.787  -42.928 1.00 74.17  ? 218  LEU   B C   1 
ATOM   6563 O  O   . LEU   B 2 217 ? -22.099 -28.536  -42.250 1.00 78.42  ? 218  LEU   B O   1 
ATOM   6564 C  CB  . LEU   B 2 217 ? -21.040 -31.255  -43.305 1.00 71.45  ? 218  LEU   B CB  1 
ATOM   6565 C  CG  . LEU   B 2 217 ? -20.458 -32.645  -43.057 1.00 70.11  ? 218  LEU   B CG  1 
ATOM   6566 C  CD1 . LEU   B 2 217 ? -21.452 -33.720  -43.469 1.00 68.75  ? 218  LEU   B CD1 1 
ATOM   6567 C  CD2 . LEU   B 2 217 ? -19.133 -32.822  -43.786 1.00 70.76  ? 218  LEU   B CD2 1 
ATOM   6568 N  N   . ALA   B 2 218 ? -20.635 -28.025  -43.929 1.00 75.75  ? 219  ALA   B N   1 
ATOM   6569 C  CA  . ALA   B 2 218 ? -21.386 -26.903  -44.542 1.00 76.88  ? 219  ALA   B CA  1 
ATOM   6570 C  C   . ALA   B 2 218 ? -21.070 -26.818  -46.040 1.00 75.09  ? 219  ALA   B C   1 
ATOM   6571 O  O   . ALA   B 2 218 ? -19.888 -26.610  -46.391 1.00 69.34  ? 219  ALA   B O   1 
ATOM   6572 C  CB  . ALA   B 2 218 ? -21.053 -25.611  -43.844 1.00 78.28  ? 219  ALA   B CB  1 
ATOM   6573 N  N   . TRP   B 2 219 ? -22.093 -26.983  -46.884 1.00 76.17  ? 220  TRP   B N   1 
ATOM   6574 C  CA  . TRP   B 2 219 ? -22.059 -26.602  -48.323 1.00 76.61  ? 220  TRP   B CA  1 
ATOM   6575 C  C   . TRP   B 2 219 ? -21.734 -25.107  -48.437 1.00 77.34  ? 220  TRP   B C   1 
ATOM   6576 O  O   . TRP   B 2 219 ? -22.283 -24.321  -47.634 1.00 75.12  ? 220  TRP   B O   1 
ATOM   6577 C  CB  . TRP   B 2 219 ? -23.397 -26.908  -49.003 1.00 73.20  ? 220  TRP   B CB  1 
ATOM   6578 C  CG  . TRP   B 2 219 ? -23.654 -28.353  -49.294 1.00 70.59  ? 220  TRP   B CG  1 
ATOM   6579 C  CD1 . TRP   B 2 219 ? -24.495 -29.188  -48.618 1.00 71.55  ? 220  TRP   B CD1 1 
ATOM   6580 C  CD2 . TRP   B 2 219 ? -23.113 -29.123  -50.381 1.00 70.77  ? 220  TRP   B CD2 1 
ATOM   6581 N  NE1 . TRP   B 2 219 ? -24.499 -30.427  -49.198 1.00 73.38  ? 220  TRP   B NE1 1 
ATOM   6582 C  CE2 . TRP   B 2 219 ? -23.661 -30.419  -50.281 1.00 69.91  ? 220  TRP   B CE2 1 
ATOM   6583 C  CE3 . TRP   B 2 219 ? -22.215 -28.850  -51.421 1.00 73.57  ? 220  TRP   B CE3 1 
ATOM   6584 C  CZ2 . TRP   B 2 219 ? -23.340 -31.436  -51.178 1.00 67.58  ? 220  TRP   B CZ2 1 
ATOM   6585 C  CZ3 . TRP   B 2 219 ? -21.893 -29.858  -52.305 1.00 71.83  ? 220  TRP   B CZ3 1 
ATOM   6586 C  CH2 . TRP   B 2 219 ? -22.450 -31.133  -52.182 1.00 69.78  ? 220  TRP   B CH2 1 
ATOM   6587 N  N   . HIS   B 2 220 ? -20.876 -24.730  -49.390 1.00 82.43  ? 221  HIS   B N   1 
ATOM   6588 C  CA  . HIS   B 2 220 ? -20.668 -23.319  -49.815 1.00 86.04  ? 221  HIS   B CA  1 
ATOM   6589 C  C   . HIS   B 2 220 ? -21.945 -22.854  -50.509 1.00 85.86  ? 221  HIS   B C   1 
ATOM   6590 O  O   . HIS   B 2 220 ? -22.477 -23.576  -51.349 1.00 87.90  ? 221  HIS   B O   1 
ATOM   6591 C  CB  . HIS   B 2 220 ? -19.428 -23.189  -50.713 1.00 87.89  ? 221  HIS   B CB  1 
ATOM   6592 C  CG  . HIS   B 2 220 ? -18.861 -21.810  -50.772 1.00 92.44  ? 221  HIS   B CG  1 
ATOM   6593 N  ND1 . HIS   B 2 220 ? -19.376 -20.831  -51.599 1.00 93.78  ? 221  HIS   B ND1 1 
ATOM   6594 C  CD2 . HIS   B 2 220 ? -17.821 -21.243  -50.119 1.00 95.84  ? 221  HIS   B CD2 1 
ATOM   6595 C  CE1 . HIS   B 2 220 ? -18.680 -19.721  -51.452 1.00 96.35  ? 221  HIS   B CE1 1 
ATOM   6596 N  NE2 . HIS   B 2 220 ? -17.719 -19.947  -50.550 1.00 95.39  ? 221  HIS   B NE2 1 
ATOM   6597 N  N   . PRO   B 2 221 ? -22.501 -21.670  -50.164 1.00 89.52  ? 222  PRO   B N   1 
ATOM   6598 C  CA  . PRO   B 2 221 ? -23.797 -21.256  -50.704 1.00 94.89  ? 222  PRO   B CA  1 
ATOM   6599 C  C   . PRO   B 2 221 ? -23.750 -20.866  -52.194 1.00 97.61  ? 222  PRO   B C   1 
ATOM   6600 O  O   . PRO   B 2 221 ? -24.766 -21.020  -52.851 1.00 101.02 ? 222  PRO   B O   1 
ATOM   6601 C  CB  . PRO   B 2 221 ? -24.216 -20.076  -49.809 1.00 91.69  ? 222  PRO   B CB  1 
ATOM   6602 C  CG  . PRO   B 2 221 ? -22.919 -19.533  -49.234 1.00 93.29  ? 222  PRO   B CG  1 
ATOM   6603 C  CD  . PRO   B 2 221 ? -21.930 -20.683  -49.235 1.00 91.94  ? 222  PRO   B CD  1 
ATOM   6604 N  N   . GLN   B 2 222 ? -22.592 -20.419  -52.697 1.00 96.82  ? 223  GLN   B N   1 
ATOM   6605 C  CA  . GLN   B 2 222 ? -22.409 -19.960  -54.105 1.00 100.02 ? 223  GLN   B CA  1 
ATOM   6606 C  C   . GLN   B 2 222 ? -21.951 -21.139  -54.971 1.00 102.44 ? 223  GLN   B C   1 
ATOM   6607 O  O   . GLN   B 2 222 ? -22.644 -21.456  -55.963 1.00 102.22 ? 223  GLN   B O   1 
ATOM   6608 C  CB  . GLN   B 2 222 ? -21.375 -18.833  -54.215 1.00 101.54 ? 223  GLN   B CB  1 
ATOM   6609 C  CG  . GLN   B 2 222 ? -21.366 -17.843  -53.056 1.00 102.44 ? 223  GLN   B CG  1 
ATOM   6610 C  CD  . GLN   B 2 222 ? -22.656 -17.074  -52.898 1.00 103.76 ? 223  GLN   B CD  1 
ATOM   6611 O  OE1 . GLN   B 2 222 ? -23.733 -17.520  -53.292 1.00 102.34 ? 223  GLN   B OE1 1 
ATOM   6612 N  NE2 . GLN   B 2 222 ? -22.555 -15.897  -52.303 1.00 106.22 ? 223  GLN   B NE2 1 
ATOM   6613 N  N   . GLN   B 2 223 ? -20.831 -21.758  -54.588 1.00 102.20 ? 224  GLN   B N   1 
ATOM   6614 C  CA  . GLN   B 2 223 ? -20.080 -22.760  -55.390 1.00 103.76 ? 224  GLN   B CA  1 
ATOM   6615 C  C   . GLN   B 2 223 ? -20.606 -24.155  -55.027 1.00 110.79 ? 224  GLN   B C   1 
ATOM   6616 O  O   . GLN   B 2 223 ? -19.974 -24.828  -54.193 1.00 119.41 ? 224  GLN   B O   1 
ATOM   6617 C  CB  . GLN   B 2 223 ? -18.581 -22.586  -55.130 1.00 101.07 ? 224  GLN   B CB  1 
ATOM   6618 C  CG  . GLN   B 2 223 ? -18.120 -21.133  -55.182 1.00 100.30 ? 224  GLN   B CG  1 
ATOM   6619 C  CD  . GLN   B 2 223 ? -16.723 -20.922  -54.646 1.00 103.35 ? 224  GLN   B CD  1 
ATOM   6620 O  OE1 . GLN   B 2 223 ? -16.444 -19.936  -53.965 1.00 99.80  ? 224  GLN   B OE1 1 
ATOM   6621 N  NE2 . GLN   B 2 223 ? -15.827 -21.847  -54.949 1.00 107.27 ? 224  GLN   B NE2 1 
ATOM   6622 N  N   . SER   B 2 224 ? -21.715 -24.573  -55.652 1.00 116.33 ? 225  SER   B N   1 
ATOM   6623 C  CA  . SER   B 2 224 ? -22.586 -25.700  -55.215 1.00 121.02 ? 225  SER   B CA  1 
ATOM   6624 C  C   . SER   B 2 224 ? -21.870 -27.054  -55.332 1.00 119.93 ? 225  SER   B C   1 
ATOM   6625 O  O   . SER   B 2 224 ? -22.549 -28.088  -55.152 1.00 113.77 ? 225  SER   B O   1 
ATOM   6626 C  CB  . SER   B 2 224 ? -23.892 -25.706  -55.981 1.00 123.79 ? 225  SER   B CB  1 
ATOM   6627 O  OG  . SER   B 2 224 ? -23.710 -26.181  -57.308 1.00 121.22 ? 225  SER   B OG  1 
ATOM   6628 N  N   . GLU   B 2 225 ? -20.564 -27.055  -55.621 1.00 122.77 ? 226  GLU   B N   1 
ATOM   6629 C  CA  . GLU   B 2 225 ? -19.717 -28.277  -55.689 1.00 125.80 ? 226  GLU   B CA  1 
ATOM   6630 C  C   . GLU   B 2 225 ? -18.497 -28.126  -54.768 1.00 118.65 ? 226  GLU   B C   1 
ATOM   6631 O  O   . GLU   B 2 225 ? -17.524 -28.895  -54.936 1.00 113.79 ? 226  GLU   B O   1 
ATOM   6632 C  CB  . GLU   B 2 225 ? -19.333 -28.530  -57.145 1.00 132.91 ? 226  GLU   B CB  1 
ATOM   6633 C  CG  . GLU   B 2 225 ? -20.538 -28.789  -58.032 1.00 139.62 ? 226  GLU   B CG  1 
ATOM   6634 C  CD  . GLU   B 2 225 ? -21.279 -30.071  -57.695 1.00 151.18 ? 226  GLU   B CD  1 
ATOM   6635 O  OE1 . GLU   B 2 225 ? -22.483 -29.987  -57.384 1.00 154.74 ? 226  GLU   B OE1 1 
ATOM   6636 O  OE2 . GLU   B 2 225 ? -20.647 -31.147  -57.731 1.00 161.66 ? 226  GLU   B OE2 1 
ATOM   6637 N  N   . VAL   B 2 226 ? -18.568 -27.189  -53.815 1.00 110.71 ? 227  VAL   B N   1 
ATOM   6638 C  CA  . VAL   B 2 226 ? -17.570 -26.981  -52.723 1.00 107.70 ? 227  VAL   B CA  1 
ATOM   6639 C  C   . VAL   B 2 226 ? -18.304 -27.097  -51.381 1.00 103.41 ? 227  VAL   B C   1 
ATOM   6640 O  O   . VAL   B 2 226 ? -19.482 -26.687  -51.308 1.00 100.28 ? 227  VAL   B O   1 
ATOM   6641 C  CB  . VAL   B 2 226 ? -16.850 -25.622  -52.865 1.00 107.52 ? 227  VAL   B CB  1 
ATOM   6642 C  CG1 . VAL   B 2 226 ? -16.141 -25.201  -51.584 1.00 103.09 ? 227  VAL   B CG1 1 
ATOM   6643 C  CG2 . VAL   B 2 226 ? -15.875 -25.619  -54.032 1.00 109.80 ? 227  VAL   B CG2 1 
ATOM   6644 N  N   . PHE   B 2 227 ? -17.634 -27.649  -50.366 1.00 97.58  ? 228  PHE   B N   1 
ATOM   6645 C  CA  . PHE   B 2 227 ? -18.109 -27.684  -48.959 1.00 91.23  ? 228  PHE   B CA  1 
ATOM   6646 C  C   . PHE   B 2 227 ? -16.906 -27.627  -48.015 1.00 88.90  ? 228  PHE   B C   1 
ATOM   6647 O  O   . PHE   B 2 227 ? -15.750 -27.743  -48.478 1.00 87.89  ? 228  PHE   B O   1 
ATOM   6648 C  CB  . PHE   B 2 227 ? -18.968 -28.924  -48.699 1.00 88.69  ? 228  PHE   B CB  1 
ATOM   6649 C  CG  . PHE   B 2 227 ? -18.230 -30.237  -48.759 1.00 89.86  ? 228  PHE   B CG  1 
ATOM   6650 C  CD1 . PHE   B 2 227 ? -17.663 -30.785  -47.618 1.00 86.51  ? 228  PHE   B CD1 1 
ATOM   6651 C  CD2 . PHE   B 2 227 ? -18.125 -30.940  -49.951 1.00 89.42  ? 228  PHE   B CD2 1 
ATOM   6652 C  CE1 . PHE   B 2 227 ? -16.993 -31.997  -47.672 1.00 84.34  ? 228  PHE   B CE1 1 
ATOM   6653 C  CE2 . PHE   B 2 227 ? -17.456 -32.153  -50.002 1.00 87.35  ? 228  PHE   B CE2 1 
ATOM   6654 C  CZ  . PHE   B 2 227 ? -16.892 -32.679  -48.862 1.00 86.92  ? 228  PHE   B CZ  1 
ATOM   6655 N  N   . VAL   B 2 228 ? -17.191 -27.442  -46.725 1.00 84.82  ? 229  VAL   B N   1 
ATOM   6656 C  CA  . VAL   B 2 228 ? -16.191 -27.465  -45.618 1.00 83.32  ? 229  VAL   B CA  1 
ATOM   6657 C  C   . VAL   B 2 228 ? -16.624 -28.538  -44.617 1.00 79.69  ? 229  VAL   B C   1 
ATOM   6658 O  O   . VAL   B 2 228 ? -17.844 -28.732  -44.452 1.00 77.97  ? 229  VAL   B O   1 
ATOM   6659 C  CB  . VAL   B 2 228 ? -16.046 -26.088  -44.941 1.00 86.30  ? 229  VAL   B CB  1 
ATOM   6660 C  CG1 . VAL   B 2 228 ? -15.215 -25.133  -45.782 1.00 87.96  ? 229  VAL   B CG1 1 
ATOM   6661 C  CG2 . VAL   B 2 228 ? -17.393 -25.469  -44.598 1.00 87.23  ? 229  VAL   B CG2 1 
ATOM   6662 N  N   . PHE   B 2 229 ? -15.658 -29.220  -43.997 1.00 78.31  ? 230  PHE   B N   1 
ATOM   6663 C  CA  . PHE   B 2 229 ? -15.893 -30.202  -42.908 1.00 76.91  ? 230  PHE   B CA  1 
ATOM   6664 C  C   . PHE   B 2 229 ? -14.897 -29.933  -41.776 1.00 72.92  ? 230  PHE   B C   1 
ATOM   6665 O  O   . PHE   B 2 229 ? -13.714 -29.652  -42.058 1.00 76.90  ? 230  PHE   B O   1 
ATOM   6666 C  CB  . PHE   B 2 229 ? -15.830 -31.637  -43.442 1.00 78.99  ? 230  PHE   B CB  1 
ATOM   6667 C  CG  . PHE   B 2 229 ? -14.445 -32.180  -43.691 1.00 85.36  ? 230  PHE   B CG  1 
ATOM   6668 C  CD1 . PHE   B 2 229 ? -13.747 -31.850  -44.843 1.00 89.08  ? 230  PHE   B CD1 1 
ATOM   6669 C  CD2 . PHE   B 2 229 ? -13.842 -33.035  -42.779 1.00 88.00  ? 230  PHE   B CD2 1 
ATOM   6670 C  CE1 . PHE   B 2 229 ? -12.476 -32.358  -45.074 1.00 91.16  ? 230  PHE   B CE1 1 
ATOM   6671 C  CE2 . PHE   B 2 229 ? -12.571 -33.540  -43.010 1.00 89.28  ? 230  PHE   B CE2 1 
ATOM   6672 C  CZ  . PHE   B 2 229 ? -11.890 -33.201  -44.157 1.00 91.79  ? 230  PHE   B CZ  1 
ATOM   6673 N  N   . GLY   B 2 230 ? -15.386 -29.972  -40.535 1.00 68.69  ? 231  GLY   B N   1 
ATOM   6674 C  CA  . GLY   B 2 230 ? -14.560 -29.907  -39.316 1.00 71.45  ? 231  GLY   B CA  1 
ATOM   6675 C  C   . GLY   B 2 230 ? -14.301 -31.299  -38.770 1.00 71.39  ? 231  GLY   B C   1 
ATOM   6676 O  O   . GLY   B 2 230 ? -15.225 -32.133  -38.830 1.00 73.66  ? 231  GLY   B O   1 
ATOM   6677 N  N   . ASP   B 2 231 ? -13.090 -31.557  -38.273 1.00 70.81  ? 232  ASP   B N   1 
ATOM   6678 C  CA  . ASP   B 2 231 ? -12.711 -32.872  -37.690 1.00 71.31  ? 232  ASP   B CA  1 
ATOM   6679 C  C   . ASP   B 2 231 ? -12.733 -32.763  -36.159 1.00 71.72  ? 232  ASP   B C   1 
ATOM   6680 O  O   . ASP   B 2 231 ? -12.772 -31.628  -35.637 1.00 71.22  ? 232  ASP   B O   1 
ATOM   6681 C  CB  . ASP   B 2 231 ? -11.380 -33.379  -38.260 1.00 70.48  ? 232  ASP   B CB  1 
ATOM   6682 C  CG  . ASP   B 2 231 ? -10.147 -32.625  -37.797 1.00 71.71  ? 232  ASP   B CG  1 
ATOM   6683 O  OD1 . ASP   B 2 231 ? -10.291 -31.721  -36.956 1.00 77.06  ? 232  ASP   B OD1 1 
ATOM   6684 O  OD2 . ASP   B 2 231 ? -9.045  -32.955  -38.280 1.00 75.37  ? 232  ASP   B OD2 1 
ATOM   6685 N  N   . GLU   B 2 232 ? -12.720 -33.914  -35.480 1.00 72.83  ? 233  GLU   B N   1 
ATOM   6686 C  CA  . GLU   B 2 232 ? -12.766 -34.054  -33.997 1.00 71.79  ? 233  GLU   B CA  1 
ATOM   6687 C  C   . GLU   B 2 232 ? -11.505 -33.465  -33.344 1.00 70.11  ? 233  GLU   B C   1 
ATOM   6688 O  O   . GLU   B 2 232 ? -11.457 -33.434  -32.100 1.00 69.44  ? 233  GLU   B O   1 
ATOM   6689 C  CB  . GLU   B 2 232 ? -12.891 -35.532  -33.625 1.00 73.18  ? 233  GLU   B CB  1 
ATOM   6690 C  CG  . GLU   B 2 232 ? -11.670 -36.349  -34.015 1.00 73.48  ? 233  GLU   B CG  1 
ATOM   6691 C  CD  . GLU   B 2 232 ? -11.803 -37.850  -33.832 1.00 72.84  ? 233  GLU   B CD  1 
ATOM   6692 O  OE1 . GLU   B 2 232 ? -12.761 -38.281  -33.154 1.00 73.56  ? 233  GLU   B OE1 1 
ATOM   6693 O  OE2 . GLU   B 2 232 ? -10.952 -38.582  -34.382 1.00 70.83  ? 233  GLU   B OE2 1 
ATOM   6694 N  N   . ASN   B 2 233 ? -10.525 -33.027  -34.141 1.00 69.09  ? 234  ASN   B N   1 
ATOM   6695 C  CA  . ASN   B 2 233 ? -9.201  -32.542  -33.665 1.00 72.26  ? 234  ASN   B CA  1 
ATOM   6696 C  C   . ASN   B 2 233 ? -9.074  -31.021  -33.846 1.00 71.43  ? 234  ASN   B C   1 
ATOM   6697 O  O   . ASN   B 2 233 ? -7.968  -30.503  -33.610 1.00 71.18  ? 234  ASN   B O   1 
ATOM   6698 C  CB  . ASN   B 2 233 ? -8.063  -33.269  -34.387 1.00 73.29  ? 234  ASN   B CB  1 
ATOM   6699 C  CG  . ASN   B 2 233 ? -6.730  -33.142  -33.683 1.00 72.77  ? 234  ASN   B CG  1 
ATOM   6700 O  OD1 . ASN   B 2 233 ? -6.673  -33.039  -32.457 1.00 77.01  ? 234  ASN   B OD1 1 
ATOM   6701 N  ND2 . ASN   B 2 233 ? -5.654  -33.152  -34.451 1.00 72.14  ? 234  ASN   B ND2 1 
ATOM   6702 N  N   . GLY   B 2 234 ? -10.150 -30.337  -34.254 1.00 73.11  ? 235  GLY   B N   1 
ATOM   6703 C  CA  . GLY   B 2 234 ? -10.226 -28.863  -34.309 1.00 74.10  ? 235  GLY   B CA  1 
ATOM   6704 C  C   . GLY   B 2 234 ? -9.877  -28.292  -35.677 1.00 74.20  ? 235  GLY   B C   1 
ATOM   6705 O  O   . GLY   B 2 234 ? -9.988  -27.062  -35.839 1.00 74.16  ? 235  GLY   B O   1 
ATOM   6706 N  N   . THR   B 2 235 ? -9.471  -29.137  -36.629 1.00 74.08  ? 236  THR   B N   1 
ATOM   6707 C  CA  . THR   B 2 235 ? -9.117  -28.737  -38.017 1.00 74.85  ? 236  THR   B CA  1 
ATOM   6708 C  C   . THR   B 2 235 ? -10.406 -28.464  -38.803 1.00 74.81  ? 236  THR   B C   1 
ATOM   6709 O  O   . THR   B 2 235 ? -11.321 -29.313  -38.762 1.00 70.08  ? 236  THR   B O   1 
ATOM   6710 C  CB  . THR   B 2 235 ? -8.222  -29.796  -38.679 1.00 74.43  ? 236  THR   B CB  1 
ATOM   6711 O  OG1 . THR   B 2 235 ? -7.001  -29.850  -37.940 1.00 74.84  ? 236  THR   B OG1 1 
ATOM   6712 C  CG2 . THR   B 2 235 ? -7.923  -29.521  -40.137 1.00 72.04  ? 236  THR   B CG2 1 
ATOM   6713 N  N   . VAL   B 2 236 ? -10.476 -27.306  -39.467 1.00 77.11  ? 237  VAL   B N   1 
ATOM   6714 C  CA  . VAL   B 2 236 ? -11.495 -26.985  -40.511 1.00 78.89  ? 237  VAL   B CA  1 
ATOM   6715 C  C   . VAL   B 2 236 ? -10.817 -27.159  -41.872 1.00 81.02  ? 237  VAL   B C   1 
ATOM   6716 O  O   . VAL   B 2 236 ? -9.647  -26.734  -42.006 1.00 81.63  ? 237  VAL   B O   1 
ATOM   6717 C  CB  . VAL   B 2 236 ? -12.065 -25.564  -40.345 1.00 77.12  ? 237  VAL   B CB  1 
ATOM   6718 C  CG1 . VAL   B 2 236 ? -13.166 -25.286  -41.358 1.00 78.89  ? 237  VAL   B CG1 1 
ATOM   6719 C  CG2 . VAL   B 2 236 ? -12.566 -25.317  -38.931 1.00 76.48  ? 237  VAL   B CG2 1 
ATOM   6720 N  N   . SER   B 2 237 ? -11.518 -27.764  -42.835 1.00 78.68  ? 238  SER   B N   1 
ATOM   6721 C  CA  . SER   B 2 237 ? -10.966 -28.130  -44.165 1.00 83.32  ? 238  SER   B CA  1 
ATOM   6722 C  C   . SER   B 2 237 ? -11.917 -27.686  -45.282 1.00 84.17  ? 238  SER   B C   1 
ATOM   6723 O  O   . SER   B 2 237 ? -13.142 -27.814  -45.106 1.00 82.85  ? 238  SER   B O   1 
ATOM   6724 C  CB  . SER   B 2 237 ? -10.679 -29.605  -44.226 1.00 84.80  ? 238  SER   B CB  1 
ATOM   6725 O  OG  . SER   B 2 237 ? -9.567  -29.928  -43.406 1.00 86.08  ? 238  SER   B OG  1 
ATOM   6726 N  N   . LEU   B 2 238 ? -11.350 -27.187  -46.385 1.00 88.55  ? 239  LEU   B N   1 
ATOM   6727 C  CA  . LEU   B 2 238 ? -12.079 -26.713  -47.593 1.00 92.66  ? 239  LEU   B CA  1 
ATOM   6728 C  C   . LEU   B 2 238 ? -11.893 -27.736  -48.719 1.00 92.46  ? 239  LEU   B C   1 
ATOM   6729 O  O   . LEU   B 2 238 ? -10.737 -27.955  -49.135 1.00 91.71  ? 239  LEU   B O   1 
ATOM   6730 C  CB  . LEU   B 2 238 ? -11.534 -25.336  -47.985 1.00 93.78  ? 239  LEU   B CB  1 
ATOM   6731 C  CG  . LEU   B 2 238 ? -12.123 -24.701  -49.245 1.00 95.03  ? 239  LEU   B CG  1 
ATOM   6732 C  CD1 . LEU   B 2 238 ? -13.618 -24.958  -49.367 1.00 97.86  ? 239  LEU   B CD1 1 
ATOM   6733 C  CD2 . LEU   B 2 238 ? -11.845 -23.207  -49.260 1.00 95.23  ? 239  LEU   B CD2 1 
ATOM   6734 N  N   . VAL   B 2 239 ? -12.994 -28.334  -49.182 1.00 93.06  ? 240  VAL   B N   1 
ATOM   6735 C  CA  . VAL   B 2 239 ? -12.998 -29.418  -50.206 1.00 98.15  ? 240  VAL   B CA  1 
ATOM   6736 C  C   . VAL   B 2 239 ? -13.770 -28.938  -51.437 1.00 102.29 ? 240  VAL   B C   1 
ATOM   6737 O  O   . VAL   B 2 239 ? -14.899 -28.439  -51.274 1.00 99.94  ? 240  VAL   B O   1 
ATOM   6738 C  CB  . VAL   B 2 239 ? -13.611 -30.718  -49.653 1.00 98.27  ? 240  VAL   B CB  1 
ATOM   6739 C  CG1 . VAL   B 2 239 ? -13.395 -31.887  -50.602 1.00 99.88  ? 240  VAL   B CG1 1 
ATOM   6740 C  CG2 . VAL   B 2 239 ? -13.076 -31.045  -48.269 1.00 99.56  ? 240  VAL   B CG2 1 
ATOM   6741 N  N   . ASP   B 2 240 ? -13.160 -29.090  -52.614 1.00 108.39 ? 241  ASP   B N   1 
ATOM   6742 C  CA  . ASP   B 2 240 ? -13.821 -28.996  -53.942 1.00 116.88 ? 241  ASP   B CA  1 
ATOM   6743 C  C   . ASP   B 2 240 ? -14.040 -30.437  -54.419 1.00 122.38 ? 241  ASP   B C   1 
ATOM   6744 O  O   . ASP   B 2 240 ? -13.082 -31.231  -54.334 1.00 128.72 ? 241  ASP   B O   1 
ATOM   6745 C  CB  . ASP   B 2 240 ? -12.967 -28.151  -54.895 1.00 117.70 ? 241  ASP   B CB  1 
ATOM   6746 C  CG  . ASP   B 2 240 ? -13.695 -27.531  -56.078 1.00 118.12 ? 241  ASP   B CG  1 
ATOM   6747 O  OD1 . ASP   B 2 240 ? -14.743 -28.074  -56.487 1.00 118.34 ? 241  ASP   B OD1 1 
ATOM   6748 O  OD2 . ASP   B 2 240 ? -13.196 -26.507  -56.591 1.00 110.15 ? 241  ASP   B OD2 1 
ATOM   6749 N  N   . THR   B 2 241 ? -15.260 -30.782  -54.844 1.00 124.91 ? 242  THR   B N   1 
ATOM   6750 C  CA  . THR   B 2 241 ? -15.599 -32.126  -55.384 1.00 127.85 ? 242  THR   B CA  1 
ATOM   6751 C  C   . THR   B 2 241 ? -14.772 -32.393  -56.647 1.00 137.80 ? 242  THR   B C   1 
ATOM   6752 O  O   . THR   B 2 241 ? -14.238 -33.514  -56.779 1.00 137.94 ? 242  THR   B O   1 
ATOM   6753 C  CB  . THR   B 2 241 ? -17.087 -32.265  -55.721 1.00 122.73 ? 242  THR   B CB  1 
ATOM   6754 O  OG1 . THR   B 2 241 ? -17.841 -32.044  -54.530 1.00 112.25 ? 242  THR   B OG1 1 
ATOM   6755 C  CG2 . THR   B 2 241 ? -17.416 -33.621  -56.306 1.00 121.27 ? 242  THR   B CG2 1 
ATOM   6756 N  N   . LYS   B 2 242 ? -14.692 -31.396  -57.535 1.00 148.69 ? 243  LYS   B N   1 
ATOM   6757 C  CA  . LYS   B 2 242 ? -13.986 -31.468  -58.844 1.00 154.63 ? 243  LYS   B CA  1 
ATOM   6758 C  C   . LYS   B 2 242 ? -12.487 -31.591  -58.583 1.00 163.14 ? 243  LYS   B C   1 
ATOM   6759 O  O   . LYS   B 2 242 ? -11.822 -32.373  -59.293 1.00 172.30 ? 243  LYS   B O   1 
ATOM   6760 C  CB  . LYS   B 2 242 ? -14.258 -30.224  -59.697 1.00 152.54 ? 243  LYS   B CB  1 
ATOM   6761 C  CG  . LYS   B 2 242 ? -15.711 -29.775  -59.733 1.00 150.66 ? 243  LYS   B CG  1 
ATOM   6762 C  CD  . LYS   B 2 242 ? -16.688 -30.931  -59.742 1.00 149.35 ? 243  LYS   B CD  1 
ATOM   6763 C  CE  . LYS   B 2 242 ? -18.117 -30.476  -59.587 1.00 148.66 ? 243  LYS   B CE  1 
ATOM   6764 N  NZ  . LYS   B 2 242 ? -18.552 -29.658  -60.742 1.00 150.49 ? 243  LYS   B NZ  1 
ATOM   6765 N  N   . SER   B 2 243 ? -11.987 -30.834  -57.605 1.00 164.73 ? 244  SER   B N   1 
ATOM   6766 C  CA  . SER   B 2 243 ? -10.559 -30.899  -57.186 1.00 163.90 ? 244  SER   B CA  1 
ATOM   6767 C  C   . SER   B 2 243 ? -10.281 -32.236  -56.503 1.00 170.69 ? 244  SER   B C   1 
ATOM   6768 O  O   . SER   B 2 243 ? -9.178  -32.801  -56.679 1.00 166.35 ? 244  SER   B O   1 
ATOM   6769 C  CB  . SER   B 2 243 ? -10.171 -29.744  -56.309 1.00 160.21 ? 244  SER   B CB  1 
ATOM   6770 O  OG  . SER   B 2 243 ? -9.941  -28.583  -57.090 1.00 152.37 ? 244  SER   B OG  1 
ATOM   6771 N  N   . THR   B 2 244 ? -11.260 -32.720  -55.752 1.00 176.27 ? 245  THR   B N   1 
ATOM   6772 C  CA  . THR   B 2 244 ? -11.140 -33.995  -55.002 1.00 172.94 ? 245  THR   B CA  1 
ATOM   6773 C  C   . THR   B 2 244 ? -10.046 -33.884  -53.933 1.00 173.30 ? 245  THR   B C   1 
ATOM   6774 O  O   . THR   B 2 244 ? -10.110 -32.977  -53.086 1.00 176.38 ? 245  THR   B O   1 
ATOM   6775 C  CB  . THR   B 2 244 ? -10.842 -35.181  -55.929 1.00 171.87 ? 245  THR   B CB  1 
ATOM   6776 O  OG1 . THR   B 2 244 ? -11.819 -35.221  -56.969 1.00 167.20 ? 245  THR   B OG1 1 
ATOM   6777 C  CG2 . THR   B 2 244 ? -10.870 -36.481  -55.155 1.00 168.66 ? 245  THR   B CG2 1 
ATOM   6778 N  N   . SER   B 2 245 ? -9.076  -34.793  -53.970 1.00 169.84 ? 246  SER   B N   1 
ATOM   6779 C  CA  . SER   B 2 245 ? -8.050  -34.948  -52.900 1.00 163.31 ? 246  SER   B CA  1 
ATOM   6780 C  C   . SER   B 2 245 ? -7.291  -33.644  -52.583 1.00 163.77 ? 246  SER   B C   1 
ATOM   6781 O  O   . SER   B 2 245 ? -6.932  -33.476  -51.402 1.00 166.54 ? 246  SER   B O   1 
ATOM   6782 C  CB  . SER   B 2 245 ? -7.096  -36.061  -53.206 1.00 159.39 ? 246  SER   B CB  1 
ATOM   6783 O  OG  . SER   B 2 245 ? -6.307  -36.349  -52.063 1.00 155.21 ? 246  SER   B OG  1 
ATOM   6784 N  N   . CYS   B 2 246 ? -7.013  -32.766  -53.558 1.00 159.12 ? 247  CYS   B N   1 
ATOM   6785 C  CA  . CYS   B 2 246 ? -6.325  -31.457  -53.325 1.00 152.08 ? 247  CYS   B CA  1 
ATOM   6786 C  C   . CYS   B 2 246 ? -7.158  -30.615  -52.346 1.00 147.39 ? 247  CYS   B C   1 
ATOM   6787 O  O   . CYS   B 2 246 ? -8.344  -30.384  -52.655 1.00 153.08 ? 247  CYS   B O   1 
ATOM   6788 C  CB  . CYS   B 2 246 ? -6.130  -30.662  -54.613 1.00 149.04 ? 247  CYS   B CB  1 
ATOM   6789 S  SG  . CYS   B 2 246 ? -5.670  -31.666  -56.050 1.00 146.04 ? 247  CYS   B SG  1 
ATOM   6790 N  N   . VAL   B 2 247 ? -6.575  -30.163  -51.226 1.00 137.09 ? 248  VAL   B N   1 
ATOM   6791 C  CA  . VAL   B 2 247 ? -7.335  -29.534  -50.098 1.00 130.20 ? 248  VAL   B CA  1 
ATOM   6792 C  C   . VAL   B 2 247 ? -6.557  -28.349  -49.502 1.00 126.00 ? 248  VAL   B C   1 
ATOM   6793 O  O   . VAL   B 2 247 ? -5.314  -28.327  -49.606 1.00 126.00 ? 248  VAL   B O   1 
ATOM   6794 C  CB  . VAL   B 2 247 ? -7.696  -30.577  -49.017 1.00 126.60 ? 248  VAL   B CB  1 
ATOM   6795 C  CG1 . VAL   B 2 247 ? -6.543  -31.522  -48.713 1.00 126.25 ? 248  VAL   B CG1 1 
ATOM   6796 C  CG2 . VAL   B 2 247 ? -8.203  -29.939  -47.730 1.00 124.13 ? 248  VAL   B CG2 1 
ATOM   6797 N  N   . LEU   B 2 248 ? -7.306  -27.405  -48.918 1.00 118.45 ? 249  LEU   B N   1 
ATOM   6798 C  CA  . LEU   B 2 248 ? -6.842  -26.283  -48.056 1.00 112.82 ? 249  LEU   B CA  1 
ATOM   6799 C  C   . LEU   B 2 248 ? -7.454  -26.465  -46.657 1.00 106.79 ? 249  LEU   B C   1 
ATOM   6800 O  O   . LEU   B 2 248 ? -8.649  -26.816  -46.592 1.00 105.72 ? 249  LEU   B O   1 
ATOM   6801 C  CB  . LEU   B 2 248 ? -7.309  -24.976  -48.707 1.00 113.25 ? 249  LEU   B CB  1 
ATOM   6802 C  CG  . LEU   B 2 248 ? -6.911  -23.681  -48.000 1.00 113.82 ? 249  LEU   B CG  1 
ATOM   6803 C  CD1 . LEU   B 2 248 ? -5.429  -23.395  -48.186 1.00 113.22 ? 249  LEU   B CD1 1 
ATOM   6804 C  CD2 . LEU   B 2 248 ? -7.745  -22.516  -48.512 1.00 113.32 ? 249  LEU   B CD2 1 
ATOM   6805 N  N   . SER   B 2 249 ? -6.683  -26.249  -45.582 1.00 99.36  ? 250  SER   B N   1 
ATOM   6806 C  CA  . SER   B 2 249 ? -7.118  -26.491  -44.177 1.00 97.27  ? 250  SER   B CA  1 
ATOM   6807 C  C   . SER   B 2 249 ? -6.376  -25.578  -43.193 1.00 94.48  ? 250  SER   B C   1 
ATOM   6808 O  O   . SER   B 2 249 ? -5.277  -25.100  -43.538 1.00 94.88  ? 250  SER   B O   1 
ATOM   6809 C  CB  . SER   B 2 249 ? -6.931  -27.939  -43.798 1.00 98.65  ? 250  SER   B CB  1 
ATOM   6810 O  OG  . SER   B 2 249 ? -5.552  -28.256  -43.662 1.00 95.61  ? 250  SER   B OG  1 
ATOM   6811 N  N   . SER   B 2 250 ? -6.963  -25.372  -42.006 1.00 90.19  ? 251  SER   B N   1 
ATOM   6812 C  CA  . SER   B 2 250 ? -6.375  -24.616  -40.868 1.00 86.36  ? 251  SER   B CA  1 
ATOM   6813 C  C   . SER   B 2 250 ? -6.777  -25.261  -39.534 1.00 84.12  ? 251  SER   B C   1 
ATOM   6814 O  O   . SER   B 2 250 ? -7.977  -25.563  -39.352 1.00 85.02  ? 251  SER   B O   1 
ATOM   6815 C  CB  . SER   B 2 250 ? -6.781  -23.166  -40.909 1.00 83.96  ? 251  SER   B CB  1 
ATOM   6816 O  OG  . SER   B 2 250 ? -5.997  -22.397  -40.009 1.00 82.95  ? 251  SER   B OG  1 
ATOM   6817 N  N   . ALA   B 2 251 ? -5.801  -25.463  -38.643 1.00 80.29  ? 252  ALA   B N   1 
ATOM   6818 C  CA  . ALA   B 2 251 ? -5.996  -25.902  -37.242 1.00 80.45  ? 252  ALA   B CA  1 
ATOM   6819 C  C   . ALA   B 2 251 ? -6.591  -24.735  -36.447 1.00 78.98  ? 252  ALA   B C   1 
ATOM   6820 O  O   . ALA   B 2 251 ? -5.818  -23.968  -35.842 1.00 79.36  ? 252  ALA   B O   1 
ATOM   6821 C  CB  . ALA   B 2 251 ? -4.687  -26.372  -36.653 1.00 79.04  ? 252  ALA   B CB  1 
ATOM   6822 N  N   . VAL   B 2 252 ? -7.919  -24.601  -36.473 1.00 78.89  ? 253  VAL   B N   1 
ATOM   6823 C  CA  . VAL   B 2 252 ? -8.660  -23.420  -35.935 1.00 78.52  ? 253  VAL   B CA  1 
ATOM   6824 C  C   . VAL   B 2 252 ? -8.890  -23.610  -34.432 1.00 79.26  ? 253  VAL   B C   1 
ATOM   6825 O  O   . VAL   B 2 252 ? -8.613  -22.666  -33.673 1.00 82.54  ? 253  VAL   B O   1 
ATOM   6826 C  CB  . VAL   B 2 252 ? -9.979  -23.195  -36.703 1.00 75.68  ? 253  VAL   B CB  1 
ATOM   6827 C  CG1 . VAL   B 2 252 ? -10.958 -22.312  -35.942 1.00 74.87  ? 253  VAL   B CG1 1 
ATOM   6828 C  CG2 . VAL   B 2 252 ? -9.715  -22.624  -38.088 1.00 74.86  ? 253  VAL   B CG2 1 
ATOM   6829 N  N   . HIS   B 2 253 ? -9.374  -24.785  -34.024 1.00 81.38  ? 254  HIS   B N   1 
ATOM   6830 C  CA  . HIS   B 2 253 ? -9.823  -25.081  -32.638 1.00 80.98  ? 254  HIS   B CA  1 
ATOM   6831 C  C   . HIS   B 2 253 ? -8.848  -26.044  -31.945 1.00 80.05  ? 254  HIS   B C   1 
ATOM   6832 O  O   . HIS   B 2 253 ? -8.051  -26.706  -32.644 1.00 75.79  ? 254  HIS   B O   1 
ATOM   6833 C  CB  . HIS   B 2 253 ? -11.263 -25.605  -32.671 1.00 79.93  ? 254  HIS   B CB  1 
ATOM   6834 C  CG  . HIS   B 2 253 ? -12.265 -24.565  -33.049 1.00 80.92  ? 254  HIS   B CG  1 
ATOM   6835 N  ND1 . HIS   B 2 253 ? -12.484 -23.440  -32.280 1.00 83.20  ? 254  HIS   B ND1 1 
ATOM   6836 C  CD2 . HIS   B 2 253 ? -13.126 -24.487  -34.086 1.00 80.86  ? 254  HIS   B CD2 1 
ATOM   6837 C  CE1 . HIS   B 2 253 ? -13.431 -22.709  -32.834 1.00 82.73  ? 254  HIS   B CE1 1 
ATOM   6838 N  NE2 . HIS   B 2 253 ? -13.842 -23.330  -33.943 1.00 80.81  ? 254  HIS   B NE2 1 
ATOM   6839 N  N   . SER   B 2 254 ? -8.905  -26.088  -30.611 1.00 78.45  ? 255  SER   B N   1 
ATOM   6840 C  CA  . SER   B 2 254 ? -8.087  -26.971  -29.738 1.00 82.59  ? 255  SER   B CA  1 
ATOM   6841 C  C   . SER   B 2 254 ? -8.860  -28.261  -29.429 1.00 84.78  ? 255  SER   B C   1 
ATOM   6842 O  O   . SER   B 2 254 ? -8.207  -29.278  -29.114 1.00 93.69  ? 255  SER   B O   1 
ATOM   6843 C  CB  . SER   B 2 254 ? -7.686  -26.257  -28.474 1.00 79.02  ? 255  SER   B CB  1 
ATOM   6844 O  OG  . SER   B 2 254 ? -8.802  -26.091  -27.613 1.00 79.14  ? 255  SER   B OG  1 
ATOM   6845 N  N   . GLN   B 2 255 ? -10.195 -28.211  -29.502 1.00 82.84  ? 256  GLN   B N   1 
ATOM   6846 C  CA  . GLN   B 2 255 ? -11.098 -29.384  -29.352 1.00 80.97  ? 256  GLN   B CA  1 
ATOM   6847 C  C   . GLN   B 2 255 ? -11.962 -29.526  -30.611 1.00 78.13  ? 256  GLN   B C   1 
ATOM   6848 O  O   . GLN   B 2 255 ? -11.795 -28.715  -31.542 1.00 79.29  ? 256  GLN   B O   1 
ATOM   6849 C  CB  . GLN   B 2 255 ? -11.960 -29.240  -28.095 1.00 83.59  ? 256  GLN   B CB  1 
ATOM   6850 C  CG  . GLN   B 2 255 ? -11.257 -29.680  -26.819 1.00 87.22  ? 256  GLN   B CG  1 
ATOM   6851 C  CD  . GLN   B 2 255 ? -12.201 -29.702  -25.643 1.00 92.65  ? 256  GLN   B CD  1 
ATOM   6852 O  OE1 . GLN   B 2 255 ? -12.063 -28.928  -24.698 1.00 97.80  ? 256  GLN   B OE1 1 
ATOM   6853 N  NE2 . GLN   B 2 255 ? -13.189 -30.580  -25.703 1.00 97.05  ? 256  GLN   B NE2 1 
ATOM   6854 N  N   . CYS   B 2 256 ? -12.834 -30.538  -30.618 1.00 76.50  ? 257  CYS   B N   1 
ATOM   6855 C  CA  . CYS   B 2 256 ? -13.789 -30.909  -31.699 1.00 75.46  ? 257  CYS   B CA  1 
ATOM   6856 C  C   . CYS   B 2 256 ? -14.418 -29.667  -32.349 1.00 76.68  ? 257  CYS   B C   1 
ATOM   6857 O  O   . CYS   B 2 256 ? -14.694 -28.697  -31.620 1.00 78.77  ? 257  CYS   B O   1 
ATOM   6858 C  CB  . CYS   B 2 256 ? -14.882 -31.791  -31.109 1.00 76.49  ? 257  CYS   B CB  1 
ATOM   6859 S  SG  . CYS   B 2 256 ? -16.253 -32.125  -32.241 1.00 83.47  ? 257  CYS   B SG  1 
ATOM   6860 N  N   . VAL   B 2 257 ? -14.648 -29.711  -33.668 1.00 76.72  ? 258  VAL   B N   1 
ATOM   6861 C  CA  . VAL   B 2 257 ? -15.424 -28.690  -34.440 1.00 71.35  ? 258  VAL   B CA  1 
ATOM   6862 C  C   . VAL   B 2 257 ? -16.884 -29.149  -34.504 1.00 68.41  ? 258  VAL   B C   1 
ATOM   6863 O  O   . VAL   B 2 257 ? -17.167 -30.090  -35.264 1.00 67.80  ? 258  VAL   B O   1 
ATOM   6864 C  CB  . VAL   B 2 257 ? -14.853 -28.477  -35.856 1.00 70.91  ? 258  VAL   B CB  1 
ATOM   6865 C  CG1 . VAL   B 2 257 ? -15.638 -27.427  -36.630 1.00 72.47  ? 258  VAL   B CG1 1 
ATOM   6866 C  CG2 . VAL   B 2 257 ? -13.376 -28.119  -35.829 1.00 69.91  ? 258  VAL   B CG2 1 
ATOM   6867 N  N   . THR   B 2 258 ? -17.772 -28.497  -33.747 1.00 73.81  ? 259  THR   B N   1 
ATOM   6868 C  CA  . THR   B 2 258 ? -19.201 -28.886  -33.580 1.00 76.00  ? 259  THR   B CA  1 
ATOM   6869 C  C   . THR   B 2 258 ? -20.023 -28.478  -34.810 1.00 75.88  ? 259  THR   B C   1 
ATOM   6870 O  O   . THR   B 2 258 ? -20.902 -29.266  -35.213 1.00 75.19  ? 259  THR   B O   1 
ATOM   6871 C  CB  . THR   B 2 258 ? -19.820 -28.244  -32.331 1.00 76.65  ? 259  THR   B CB  1 
ATOM   6872 O  OG1 . THR   B 2 258 ? -18.972 -28.514  -31.215 1.00 80.81  ? 259  THR   B OG1 1 
ATOM   6873 C  CG2 . THR   B 2 258 ? -21.220 -28.745  -32.047 1.00 77.98  ? 259  THR   B CG2 1 
ATOM   6874 N  N   . GLY   B 2 259 ? -19.766 -27.288  -35.360 1.00 72.80  ? 260  GLY   B N   1 
ATOM   6875 C  CA  . GLY   B 2 259 ? -20.627 -26.660  -36.379 1.00 74.58  ? 260  GLY   B CA  1 
ATOM   6876 C  C   . GLY   B 2 259 ? -19.865 -25.701  -37.277 1.00 76.84  ? 260  GLY   B C   1 
ATOM   6877 O  O   . GLY   B 2 259 ? -18.890 -25.075  -36.804 1.00 73.61  ? 260  GLY   B O   1 
ATOM   6878 N  N   . LEU   B 2 260 ? -20.304 -25.600  -38.534 1.00 79.46  ? 261  LEU   B N   1 
ATOM   6879 C  CA  . LEU   B 2 260 ? -19.787 -24.653  -39.557 1.00 81.15  ? 261  LEU   B CA  1 
ATOM   6880 C  C   . LEU   B 2 260 ? -20.986 -23.995  -40.249 1.00 83.51  ? 261  LEU   B C   1 
ATOM   6881 O  O   . LEU   B 2 260 ? -21.835 -24.738  -40.791 1.00 86.23  ? 261  LEU   B O   1 
ATOM   6882 C  CB  . LEU   B 2 260 ? -18.916 -25.426  -40.553 1.00 79.41  ? 261  LEU   B CB  1 
ATOM   6883 C  CG  . LEU   B 2 260 ? -17.580 -25.931  -40.009 1.00 79.98  ? 261  LEU   B CG  1 
ATOM   6884 C  CD1 . LEU   B 2 260 ? -16.956 -26.952  -40.948 1.00 80.76  ? 261  LEU   B CD1 1 
ATOM   6885 C  CD2 . LEU   B 2 260 ? -16.617 -24.779  -39.768 1.00 80.68  ? 261  LEU   B CD2 1 
ATOM   6886 N  N   . VAL   B 2 261 ? -21.075 -22.663  -40.197 1.00 83.81  ? 262  VAL   B N   1 
ATOM   6887 C  CA  . VAL   B 2 261 ? -22.199 -21.884  -40.800 1.00 86.34  ? 262  VAL   B CA  1 
ATOM   6888 C  C   . VAL   B 2 261 ? -21.618 -20.699  -41.579 1.00 82.89  ? 262  VAL   B C   1 
ATOM   6889 O  O   . VAL   B 2 261 ? -20.908 -19.872  -40.966 1.00 73.71  ? 262  VAL   B O   1 
ATOM   6890 C  CB  . VAL   B 2 261 ? -23.218 -21.423  -39.740 1.00 87.65  ? 262  VAL   B CB  1 
ATOM   6891 C  CG1 . VAL   B 2 261 ? -24.511 -20.946  -40.384 1.00 86.46  ? 262  VAL   B CG1 1 
ATOM   6892 C  CG2 . VAL   B 2 261 ? -23.506 -22.515  -38.719 1.00 88.85  ? 262  VAL   B CG2 1 
ATOM   6893 N  N   . PHE   B 2 262 ? -21.910 -20.647  -42.884 1.00 83.53  ? 263  PHE   B N   1 
ATOM   6894 C  CA  . PHE   B 2 262 ? -21.502 -19.566  -43.819 1.00 84.22  ? 263  PHE   B CA  1 
ATOM   6895 C  C   . PHE   B 2 262 ? -22.445 -18.370  -43.650 1.00 87.12  ? 263  PHE   B C   1 
ATOM   6896 O  O   . PHE   B 2 262 ? -23.654 -18.580  -43.421 1.00 86.24  ? 263  PHE   B O   1 
ATOM   6897 C  CB  . PHE   B 2 262 ? -21.508 -20.065  -45.268 1.00 80.24  ? 263  PHE   B CB  1 
ATOM   6898 C  CG  . PHE   B 2 262 ? -20.283 -20.837  -45.685 1.00 76.48  ? 263  PHE   B CG  1 
ATOM   6899 C  CD1 . PHE   B 2 262 ? -19.044 -20.217  -45.752 1.00 75.55  ? 263  PHE   B CD1 1 
ATOM   6900 C  CD2 . PHE   B 2 262 ? -20.370 -22.176  -46.038 1.00 75.23  ? 263  PHE   B CD2 1 
ATOM   6901 C  CE1 . PHE   B 2 262 ? -17.917 -20.922  -46.146 1.00 74.76  ? 263  PHE   B CE1 1 
ATOM   6902 C  CE2 . PHE   B 2 262 ? -19.241 -22.880  -46.431 1.00 73.49  ? 263  PHE   B CE2 1 
ATOM   6903 C  CZ  . PHE   B 2 262 ? -18.017 -22.253  -46.483 1.00 73.16  ? 263  PHE   B CZ  1 
ATOM   6904 N  N   . SER   B 2 263 ? -21.902 -17.155  -43.774 1.00 93.28  ? 264  SER   B N   1 
ATOM   6905 C  CA  . SER   B 2 263 ? -22.649 -15.872  -43.684 1.00 98.48  ? 264  SER   B CA  1 
ATOM   6906 C  C   . SER   B 2 263 ? -23.512 -15.680  -44.931 1.00 98.73  ? 264  SER   B C   1 
ATOM   6907 O  O   . SER   B 2 263 ? -23.256 -16.300  -45.962 1.00 93.98  ? 264  SER   B O   1 
ATOM   6908 C  CB  . SER   B 2 263 ? -21.710 -14.710  -43.490 1.00 100.08 ? 264  SER   B CB  1 
ATOM   6909 O  OG  . SER   B 2 263 ? -20.917 -14.499  -44.649 1.00 100.74 ? 264  SER   B OG  1 
ATOM   6910 N  N   . PRO   B 2 264 ? -24.552 -14.813  -44.879 1.00 102.32 ? 265  PRO   B N   1 
ATOM   6911 C  CA  . PRO   B 2 264 ? -25.360 -14.492  -46.056 1.00 103.45 ? 265  PRO   B CA  1 
ATOM   6912 C  C   . PRO   B 2 264 ? -24.678 -13.479  -46.993 1.00 102.92 ? 265  PRO   B C   1 
ATOM   6913 O  O   . PRO   B 2 264 ? -25.259 -13.177  -48.018 1.00 98.37  ? 265  PRO   B O   1 
ATOM   6914 C  CB  . PRO   B 2 264 ? -26.657 -13.895  -45.474 1.00 103.03 ? 265  PRO   B CB  1 
ATOM   6915 C  CG  . PRO   B 2 264 ? -26.528 -14.032  -43.963 1.00 101.83 ? 265  PRO   B CG  1 
ATOM   6916 C  CD  . PRO   B 2 264 ? -25.042 -14.107  -43.687 1.00 101.87 ? 265  PRO   B CD  1 
ATOM   6917 N  N   . HIS   B 2 265 ? -23.485 -12.991  -46.621 1.00 104.45 ? 266  HIS   B N   1 
ATOM   6918 C  CA  . HIS   B 2 265 ? -22.642 -12.031  -47.390 1.00 108.98 ? 266  HIS   B CA  1 
ATOM   6919 C  C   . HIS   B 2 265 ? -22.452 -12.491  -48.841 1.00 111.46 ? 266  HIS   B C   1 
ATOM   6920 O  O   . HIS   B 2 265 ? -22.651 -13.692  -49.122 1.00 108.56 ? 266  HIS   B O   1 
ATOM   6921 C  CB  . HIS   B 2 265 ? -21.265 -11.862  -46.729 1.00 114.86 ? 266  HIS   B CB  1 
ATOM   6922 C  CG  . HIS   B 2 265 ? -21.238 -10.924  -45.569 1.00 117.79 ? 266  HIS   B CG  1 
ATOM   6923 N  ND1 . HIS   B 2 265 ? -20.658 -9.672   -45.651 1.00 120.08 ? 266  HIS   B ND1 1 
ATOM   6924 C  CD2 . HIS   B 2 265 ? -21.685 -11.053  -44.302 1.00 120.05 ? 266  HIS   B CD2 1 
ATOM   6925 C  CE1 . HIS   B 2 265 ? -20.763 -9.064   -44.487 1.00 120.71 ? 266  HIS   B CE1 1 
ATOM   6926 N  NE2 . HIS   B 2 265 ? -21.388 -9.890   -43.642 1.00 123.99 ? 266  HIS   B NE2 1 
ATOM   6927 N  N   . SER   B 2 266 ? -22.033 -11.561  -49.708 1.00 113.91 ? 267  SER   B N   1 
ATOM   6928 C  CA  . SER   B 2 266 ? -21.778 -11.767  -51.159 1.00 111.98 ? 267  SER   B CA  1 
ATOM   6929 C  C   . SER   B 2 266 ? -20.591 -12.724  -51.349 1.00 109.28 ? 267  SER   B C   1 
ATOM   6930 O  O   . SER   B 2 266 ? -20.791 -13.790  -51.967 1.00 102.42 ? 267  SER   B O   1 
ATOM   6931 C  CB  . SER   B 2 266 ? -21.559 -10.444  -51.848 1.00 111.87 ? 267  SER   B CB  1 
ATOM   6932 O  OG  . SER   B 2 266 ? -22.695 -9.605   -51.697 1.00 108.13 ? 267  SER   B OG  1 
ATOM   6933 N  N   . VAL   B 2 267 ? -19.412 -12.358  -50.831 1.00 109.62 ? 268  VAL   B N   1 
ATOM   6934 C  CA  . VAL   B 2 267 ? -18.236 -13.270  -50.669 1.00 115.92 ? 268  VAL   B CA  1 
ATOM   6935 C  C   . VAL   B 2 267 ? -18.198 -13.700  -49.202 1.00 116.94 ? 268  VAL   B C   1 
ATOM   6936 O  O   . VAL   B 2 267 ? -17.706 -12.965  -48.347 1.00 115.57 ? 268  VAL   B O   1 
ATOM   6937 C  CB  . VAL   B 2 267 ? -16.910 -12.630  -51.138 1.00 116.46 ? 268  VAL   B CB  1 
ATOM   6938 C  CG1 . VAL   B 2 267 ? -16.678 -11.236  -50.565 1.00 118.75 ? 268  VAL   B CG1 1 
ATOM   6939 C  CG2 . VAL   B 2 267 ? -15.714 -13.531  -50.857 1.00 112.59 ? 268  VAL   B CG2 1 
ATOM   6940 N  N   . PRO   B 2 268 ? -18.714 -14.905  -48.860 1.00 116.56 ? 269  PRO   B N   1 
ATOM   6941 C  CA  . PRO   B 2 268 ? -19.158 -15.185  -47.495 1.00 114.96 ? 269  PRO   B CA  1 
ATOM   6942 C  C   . PRO   B 2 268 ? -18.031 -15.550  -46.517 1.00 109.09 ? 269  PRO   B C   1 
ATOM   6943 O  O   . PRO   B 2 268 ? -16.973 -15.982  -46.954 1.00 103.67 ? 269  PRO   B O   1 
ATOM   6944 C  CB  . PRO   B 2 268 ? -20.126 -16.359  -47.699 1.00 116.70 ? 269  PRO   B CB  1 
ATOM   6945 C  CG  . PRO   B 2 268 ? -19.556 -17.114  -48.884 1.00 118.76 ? 269  PRO   B CG  1 
ATOM   6946 C  CD  . PRO   B 2 268 ? -18.860 -16.074  -49.743 1.00 118.59 ? 269  PRO   B CD  1 
ATOM   6947 N  N   . PHE   B 2 269 ? -18.299 -15.340  -45.224 1.00 106.49 ? 270  PHE   B N   1 
ATOM   6948 C  CA  . PHE   B 2 269 ? -17.428 -15.699  -44.074 1.00 105.80 ? 270  PHE   B CA  1 
ATOM   6949 C  C   . PHE   B 2 269 ? -17.923 -17.012  -43.457 1.00 98.88  ? 270  PHE   B C   1 
ATOM   6950 O  O   . PHE   B 2 269 ? -19.125 -17.324  -43.597 1.00 95.21  ? 270  PHE   B O   1 
ATOM   6951 C  CB  . PHE   B 2 269 ? -17.431 -14.581  -43.028 1.00 108.72 ? 270  PHE   B CB  1 
ATOM   6952 C  CG  . PHE   B 2 269 ? -17.048 -13.223  -43.561 1.00 110.66 ? 270  PHE   B CG  1 
ATOM   6953 C  CD1 . PHE   B 2 269 ? -15.787 -13.003  -44.094 1.00 113.77 ? 270  PHE   B CD1 1 
ATOM   6954 C  CD2 . PHE   B 2 269 ? -17.945 -12.166  -43.525 1.00 111.88 ? 270  PHE   B CD2 1 
ATOM   6955 C  CE1 . PHE   B 2 269 ? -15.433 -11.756  -44.586 1.00 113.66 ? 270  PHE   B CE1 1 
ATOM   6956 C  CE2 . PHE   B 2 269 ? -17.588 -10.919  -44.015 1.00 111.82 ? 270  PHE   B CE2 1 
ATOM   6957 C  CZ  . PHE   B 2 269 ? -16.334 -10.716  -44.545 1.00 114.27 ? 270  PHE   B CZ  1 
ATOM   6958 N  N   . LEU   B 2 270 ? -17.029 -17.745  -42.785 1.00 92.20  ? 271  LEU   B N   1 
ATOM   6959 C  CA  . LEU   B 2 270 ? -17.324 -19.068  -42.170 1.00 86.03  ? 271  LEU   B CA  1 
ATOM   6960 C  C   . LEU   B 2 270 ? -17.205 -18.975  -40.645 1.00 79.54  ? 271  LEU   B C   1 
ATOM   6961 O  O   . LEU   B 2 270 ? -16.077 -18.792  -40.150 1.00 72.92  ? 271  LEU   B O   1 
ATOM   6962 C  CB  . LEU   B 2 270 ? -16.352 -20.109  -42.735 1.00 85.29  ? 271  LEU   B CB  1 
ATOM   6963 C  CG  . LEU   B 2 270 ? -16.606 -21.554  -42.306 1.00 84.90  ? 271  LEU   B CG  1 
ATOM   6964 C  CD1 . LEU   B 2 270 ? -18.060 -21.945  -42.528 1.00 85.00  ? 271  LEU   B CD1 1 
ATOM   6965 C  CD2 . LEU   B 2 270 ? -15.676 -22.506  -43.044 1.00 83.14  ? 271  LEU   B CD2 1 
ATOM   6966 N  N   . ALA   B 2 271 ? -18.336 -19.090  -39.944 1.00 77.33  ? 272  ALA   B N   1 
ATOM   6967 C  CA  . ALA   B 2 271 ? -18.412 -19.285  -38.477 1.00 77.34  ? 272  ALA   B CA  1 
ATOM   6968 C  C   . ALA   B 2 271 ? -18.082 -20.748  -38.166 1.00 76.06  ? 272  ALA   B C   1 
ATOM   6969 O  O   . ALA   B 2 271 ? -18.673 -21.632  -38.813 1.00 72.80  ? 272  ALA   B O   1 
ATOM   6970 C  CB  . ALA   B 2 271 ? -19.781 -18.914  -37.961 1.00 75.78  ? 272  ALA   B CB  1 
ATOM   6971 N  N   . SER   B 2 272 ? -17.164 -20.992  -37.228 1.00 78.48  ? 273  SER   B N   1 
ATOM   6972 C  CA  . SER   B 2 272 ? -16.793 -22.351  -36.753 1.00 81.21  ? 273  SER   B CA  1 
ATOM   6973 C  C   . SER   B 2 272 ? -16.991 -22.440  -35.235 1.00 78.53  ? 273  SER   B C   1 
ATOM   6974 O  O   . SER   B 2 272 ? -16.424 -21.601  -34.506 1.00 77.22  ? 273  SER   B O   1 
ATOM   6975 C  CB  . SER   B 2 272 ? -15.388 -22.722  -37.167 1.00 84.00  ? 273  SER   B CB  1 
ATOM   6976 O  OG  . SER   B 2 272 ? -14.432 -21.840  -36.601 1.00 85.26  ? 273  SER   B OG  1 
ATOM   6977 N  N   . LEU   B 2 273 ? -17.785 -23.425  -34.804 1.00 76.78  ? 274  LEU   B N   1 
ATOM   6978 C  CA  . LEU   B 2 273 ? -18.103 -23.741  -33.386 1.00 75.81  ? 274  LEU   B CA  1 
ATOM   6979 C  C   . LEU   B 2 273 ? -17.140 -24.813  -32.883 1.00 75.06  ? 274  LEU   B C   1 
ATOM   6980 O  O   . LEU   B 2 273 ? -16.569 -25.525  -33.724 1.00 79.58  ? 274  LEU   B O   1 
ATOM   6981 C  CB  . LEU   B 2 273 ? -19.522 -24.299  -33.298 1.00 74.22  ? 274  LEU   B CB  1 
ATOM   6982 C  CG  . LEU   B 2 273 ? -20.655 -23.305  -33.486 1.00 71.44  ? 274  LEU   B CG  1 
ATOM   6983 C  CD1 . LEU   B 2 273 ? -20.666 -22.724  -34.888 1.00 69.40  ? 274  LEU   B CD1 1 
ATOM   6984 C  CD2 . LEU   B 2 273 ? -21.964 -23.997  -33.190 1.00 74.25  ? 274  LEU   B CD2 1 
ATOM   6985 N  N   . SER   B 2 274 ? -17.048 -24.984  -31.564 1.00 73.94  ? 275  SER   B N   1 
ATOM   6986 C  CA  . SER   B 2 274 ? -16.143 -25.976  -30.932 1.00 75.92  ? 275  SER   B CA  1 
ATOM   6987 C  C   . SER   B 2 274 ? -16.552 -26.260  -29.481 1.00 76.49  ? 275  SER   B C   1 
ATOM   6988 O  O   . SER   B 2 274 ? -17.293 -25.443  -28.887 1.00 74.90  ? 275  SER   B O   1 
ATOM   6989 C  CB  . SER   B 2 274 ? -14.717 -25.506  -31.033 1.00 75.01  ? 275  SER   B CB  1 
ATOM   6990 O  OG  . SER   B 2 274 ? -13.815 -26.464  -30.500 1.00 74.27  ? 275  SER   B OG  1 
ATOM   6991 N  N   . GLU   B 2 275 ? -16.083 -27.397  -28.957 1.00 72.63  ? 276  GLU   B N   1 
ATOM   6992 C  CA  . GLU   B 2 275 ? -16.233 -27.815  -27.539 1.00 71.42  ? 276  GLU   B CA  1 
ATOM   6993 C  C   . GLU   B 2 275 ? -15.142 -27.135  -26.700 1.00 71.17  ? 276  GLU   B C   1 
ATOM   6994 O  O   . GLU   B 2 275 ? -15.192 -27.263  -25.457 1.00 70.55  ? 276  GLU   B O   1 
ATOM   6995 C  CB  . GLU   B 2 275 ? -16.194 -29.341  -27.438 1.00 72.31  ? 276  GLU   B CB  1 
ATOM   6996 C  CG  . GLU   B 2 275 ? -17.405 -30.006  -28.067 1.00 72.16  ? 276  GLU   B CG  1 
ATOM   6997 C  CD  . GLU   B 2 275 ? -17.433 -31.524  -28.032 1.00 74.42  ? 276  GLU   B CD  1 
ATOM   6998 O  OE1 . GLU   B 2 275 ? -16.377 -32.146  -27.786 1.00 75.74  ? 276  GLU   B OE1 1 
ATOM   6999 O  OE2 . GLU   B 2 275 ? -18.522 -32.083  -28.255 1.00 77.14  ? 276  GLU   B OE2 1 
ATOM   7000 N  N   . ASP   B 2 276 ? -14.211 -26.420  -27.348 1.00 70.41  ? 277  ASP   B N   1 
ATOM   7001 C  CA  . ASP   B 2 276 ? -13.232 -25.523  -26.671 1.00 75.87  ? 277  ASP   B CA  1 
ATOM   7002 C  C   . ASP   B 2 276 ? -13.940 -24.222  -26.254 1.00 76.88  ? 277  ASP   B C   1 
ATOM   7003 O  O   . ASP   B 2 276 ? -13.259 -23.343  -25.686 1.00 74.75  ? 277  ASP   B O   1 
ATOM   7004 C  CB  . ASP   B 2 276 ? -11.976 -25.298  -27.527 1.00 75.99  ? 277  ASP   B CB  1 
ATOM   7005 C  CG  . ASP   B 2 276 ? -12.159 -24.467  -28.790 1.00 79.89  ? 277  ASP   B CG  1 
ATOM   7006 O  OD1 . ASP   B 2 276 ? -13.208 -23.798  -28.924 1.00 79.23  ? 277  ASP   B OD1 1 
ATOM   7007 O  OD2 . ASP   B 2 276 ? -11.238 -24.491  -29.634 1.00 77.41  ? 277  ASP   B OD2 1 
ATOM   7008 N  N   . CYS   B 2 277 ? -15.244 -24.101  -26.547 1.00 78.63  ? 278  CYS   B N   1 
ATOM   7009 C  CA  . CYS   B 2 277 ? -16.167 -23.043  -26.048 1.00 80.25  ? 278  CYS   B CA  1 
ATOM   7010 C  C   . CYS   B 2 277 ? -15.932 -21.714  -26.778 1.00 82.64  ? 278  CYS   B C   1 
ATOM   7011 O  O   . CYS   B 2 277 ? -16.545 -20.709  -26.363 1.00 86.80  ? 278  CYS   B O   1 
ATOM   7012 C  CB  . CYS   B 2 277 ? -16.013 -22.825  -24.547 1.00 81.89  ? 278  CYS   B CB  1 
ATOM   7013 S  SG  . CYS   B 2 277 ? -16.227 -24.333  -23.566 1.00 78.85  ? 278  CYS   B SG  1 
ATOM   7014 N  N   . SER   B 2 278 ? -15.094 -21.706  -27.821 1.00 80.92  ? 279  SER   B N   1 
ATOM   7015 C  CA  . SER   B 2 278 ? -14.784 -20.508  -28.644 1.00 78.14  ? 279  SER   B CA  1 
ATOM   7016 C  C   . SER   B 2 278 ? -15.645 -20.511  -29.912 1.00 74.60  ? 279  SER   B C   1 
ATOM   7017 O  O   . SER   B 2 278 ? -16.128 -21.583  -30.308 1.00 70.31  ? 279  SER   B O   1 
ATOM   7018 C  CB  . SER   B 2 278 ? -13.304 -20.419  -28.972 1.00 78.38  ? 279  SER   B CB  1 
ATOM   7019 O  OG  . SER   B 2 278 ? -12.929 -21.353  -29.974 1.00 76.19  ? 279  SER   B OG  1 
ATOM   7020 N  N   . LEU   B 2 279 ? -15.849 -19.326  -30.491 1.00 79.79  ? 280  LEU   B N   1 
ATOM   7021 C  CA  . LEU   B 2 279 ? -16.335 -19.113  -31.880 1.00 78.62  ? 280  LEU   B CA  1 
ATOM   7022 C  C   . LEU   B 2 279 ? -15.178 -18.527  -32.690 1.00 74.44  ? 280  LEU   B C   1 
ATOM   7023 O  O   . LEU   B 2 279 ? -14.437 -17.693  -32.141 1.00 69.97  ? 280  LEU   B O   1 
ATOM   7024 C  CB  . LEU   B 2 279 ? -17.538 -18.161  -31.865 1.00 83.26  ? 280  LEU   B CB  1 
ATOM   7025 C  CG  . LEU   B 2 279 ? -17.945 -17.568  -33.217 1.00 85.37  ? 280  LEU   B CG  1 
ATOM   7026 C  CD1 . LEU   B 2 279 ? -18.528 -18.634  -34.135 1.00 86.97  ? 280  LEU   B CD1 1 
ATOM   7027 C  CD2 . LEU   B 2 279 ? -18.937 -16.430  -33.031 1.00 84.91  ? 280  LEU   B CD2 1 
ATOM   7028 N  N   . ALA   B 2 280 ? -15.021 -18.969  -33.935 1.00 77.68  ? 281  ALA   B N   1 
ATOM   7029 C  CA  . ALA   B 2 280 ? -14.140 -18.336  -34.940 1.00 81.91  ? 281  ALA   B CA  1 
ATOM   7030 C  C   . ALA   B 2 280 ? -15.010 -17.832  -36.090 1.00 83.18  ? 281  ALA   B C   1 
ATOM   7031 O  O   . ALA   B 2 280 ? -16.147 -18.327  -36.237 1.00 82.08  ? 281  ALA   B O   1 
ATOM   7032 C  CB  . ALA   B 2 280 ? -13.097 -19.308  -35.430 1.00 83.16  ? 281  ALA   B CB  1 
ATOM   7033 N  N   . VAL   B 2 281 ? -14.491 -16.861  -36.843 1.00 86.98  ? 282  VAL   B N   1 
ATOM   7034 C  CA  . VAL   B 2 281 ? -15.052 -16.399  -38.144 1.00 89.06  ? 282  VAL   B CA  1 
ATOM   7035 C  C   . VAL   B 2 281 ? -13.883 -16.307  -39.129 1.00 91.15  ? 282  VAL   B C   1 
ATOM   7036 O  O   . VAL   B 2 281 ? -12.851 -15.696  -38.765 1.00 84.59  ? 282  VAL   B O   1 
ATOM   7037 C  CB  . VAL   B 2 281 ? -15.810 -15.067  -37.997 1.00 90.86  ? 282  VAL   B CB  1 
ATOM   7038 C  CG1 . VAL   B 2 281 ? -16.360 -14.578  -39.330 1.00 94.37  ? 282  VAL   B CG1 1 
ATOM   7039 C  CG2 . VAL   B 2 281 ? -16.928 -15.173  -36.969 1.00 89.56  ? 282  VAL   B CG2 1 
ATOM   7040 N  N   . LEU   B 2 282 ? -14.035 -16.921  -40.308 1.00 96.35  ? 283  LEU   B N   1 
ATOM   7041 C  CA  . LEU   B 2 282 ? -12.945 -17.116  -41.303 1.00 99.90  ? 283  LEU   B CA  1 
ATOM   7042 C  C   . LEU   B 2 282 ? -13.400 -16.627  -42.683 1.00 101.16 ? 283  LEU   B C   1 
ATOM   7043 O  O   . LEU   B 2 282 ? -14.620 -16.648  -42.957 1.00 96.99  ? 283  LEU   B O   1 
ATOM   7044 C  CB  . LEU   B 2 282 ? -12.573 -18.603  -41.356 1.00 100.72 ? 283  LEU   B CB  1 
ATOM   7045 C  CG  . LEU   B 2 282 ? -12.481 -19.325  -40.012 1.00 98.72  ? 283  LEU   B CG  1 
ATOM   7046 C  CD1 . LEU   B 2 282 ? -12.456 -20.833  -40.213 1.00 98.14  ? 283  LEU   B CD1 1 
ATOM   7047 C  CD2 . LEU   B 2 282 ? -11.262 -18.867  -39.227 1.00 97.61  ? 283  LEU   B CD2 1 
ATOM   7048 N  N   . ASP   B 2 283 ? -12.437 -16.222  -43.515 1.00 101.53 ? 284  ASP   B N   1 
ATOM   7049 C  CA  . ASP   B 2 283 ? -12.629 -15.897  -44.955 1.00 102.44 ? 284  ASP   B CA  1 
ATOM   7050 C  C   . ASP   B 2 283 ? -12.520 -17.200  -45.759 1.00 103.41 ? 284  ASP   B C   1 
ATOM   7051 O  O   . ASP   B 2 283 ? -12.461 -18.275  -45.130 1.00 98.82  ? 284  ASP   B O   1 
ATOM   7052 C  CB  . ASP   B 2 283 ? -11.632 -14.824  -45.406 1.00 99.81  ? 284  ASP   B CB  1 
ATOM   7053 C  CG  . ASP   B 2 283 ? -10.195 -15.115  -45.008 1.00 98.93  ? 284  ASP   B CG  1 
ATOM   7054 O  OD1 . ASP   B 2 283 ? -9.793  -16.292  -45.073 1.00 101.03 ? 284  ASP   B OD1 1 
ATOM   7055 O  OD2 . ASP   B 2 283 ? -9.498  -14.164  -44.613 1.00 101.90 ? 284  ASP   B OD2 1 
ATOM   7056 N  N   . SER   B 2 284 ? -12.482 -17.113  -47.092 1.00 107.23 ? 285  SER   B N   1 
ATOM   7057 C  CA  . SER   B 2 284 ? -12.470 -18.278  -48.016 1.00 106.27 ? 285  SER   B CA  1 
ATOM   7058 C  C   . SER   B 2 284 ? -11.039 -18.794  -48.237 1.00 102.94 ? 285  SER   B C   1 
ATOM   7059 O  O   . SER   B 2 284 ? -10.880 -19.717  -49.062 1.00 105.31 ? 285  SER   B O   1 
ATOM   7060 C  CB  . SER   B 2 284 ? -13.150 -17.938  -49.319 1.00 110.02 ? 285  SER   B CB  1 
ATOM   7061 O  OG  . SER   B 2 284 ? -14.400 -17.301  -49.086 1.00 113.00 ? 285  SER   B OG  1 
ATOM   7062 N  N   . SER   B 2 285 ? -10.041 -18.231  -47.542 1.00 94.68  ? 286  SER   B N   1 
ATOM   7063 C  CA  . SER   B 2 285 ? -8.671  -18.801  -47.419 1.00 96.17  ? 286  SER   B CA  1 
ATOM   7064 C  C   . SER   B 2 285 ? -8.511  -19.493  -46.055 1.00 93.32  ? 286  SER   B C   1 
ATOM   7065 O  O   . SER   B 2 285 ? -7.442  -20.094  -45.825 1.00 86.18  ? 286  SER   B O   1 
ATOM   7066 C  CB  . SER   B 2 285 ? -7.610  -17.748  -47.637 1.00 97.50  ? 286  SER   B CB  1 
ATOM   7067 O  OG  . SER   B 2 285 ? -7.517  -16.872  -46.522 1.00 100.20 ? 286  SER   B OG  1 
ATOM   7068 N  N   . LEU   B 2 286 ? -9.543  -19.405  -45.203 1.00 93.26  ? 287  LEU   B N   1 
ATOM   7069 C  CA  . LEU   B 2 286 ? -9.653  -20.011  -43.843 1.00 90.77  ? 287  LEU   B CA  1 
ATOM   7070 C  C   . LEU   B 2 286 ? -8.710  -19.312  -42.854 1.00 94.49  ? 287  LEU   B C   1 
ATOM   7071 O  O   . LEU   B 2 286 ? -8.442  -19.907  -41.787 1.00 95.35  ? 287  LEU   B O   1 
ATOM   7072 C  CB  . LEU   B 2 286 ? -9.376  -21.519  -43.902 1.00 85.99  ? 287  LEU   B CB  1 
ATOM   7073 C  CG  . LEU   B 2 286 ? -10.353 -22.354  -44.731 1.00 84.52  ? 287  LEU   B CG  1 
ATOM   7074 C  CD1 . LEU   B 2 286 ? -10.000 -23.829  -44.637 1.00 85.56  ? 287  LEU   B CD1 1 
ATOM   7075 C  CD2 . LEU   B 2 286 ? -11.794 -22.131  -44.295 1.00 84.64  ? 287  LEU   B CD2 1 
ATOM   7076 N  N   . SER   B 2 287 ? -8.256  -18.090  -43.162 1.00 95.04  ? 288  SER   B N   1 
ATOM   7077 C  CA  . SER   B 2 287 ? -7.523  -17.214  -42.208 1.00 98.95  ? 288  SER   B CA  1 
ATOM   7078 C  C   . SER   B 2 287 ? -8.513  -16.652  -41.177 1.00 98.17  ? 288  SER   B C   1 
ATOM   7079 O  O   . SER   B 2 287 ? -9.704  -16.481  -41.523 1.00 93.67  ? 288  SER   B O   1 
ATOM   7080 C  CB  . SER   B 2 287 ? -6.764  -16.117  -42.915 1.00 100.65 ? 288  SER   B CB  1 
ATOM   7081 O  OG  . SER   B 2 287 ? -5.567  -16.617  -43.494 1.00 103.19 ? 288  SER   B OG  1 
ATOM   7082 N  N   . GLU   B 2 288 ? -8.031  -16.382  -39.960 1.00 97.99  ? 289  GLU   B N   1 
ATOM   7083 C  CA  . GLU   B 2 288 ? -8.859  -16.040  -38.771 1.00 101.47 ? 289  GLU   B CA  1 
ATOM   7084 C  C   . GLU   B 2 288 ? -9.100  -14.526  -38.729 1.00 101.45 ? 289  GLU   B C   1 
ATOM   7085 O  O   . GLU   B 2 288 ? -8.113  -13.775  -38.620 1.00 96.27  ? 289  GLU   B O   1 
ATOM   7086 C  CB  . GLU   B 2 288 ? -8.165  -16.536  -37.500 1.00 103.41 ? 289  GLU   B CB  1 
ATOM   7087 C  CG  . GLU   B 2 288 ? -9.047  -16.514  -36.262 1.00 104.84 ? 289  GLU   B CG  1 
ATOM   7088 C  CD  . GLU   B 2 288 ? -8.345  -16.944  -34.983 1.00 102.46 ? 289  GLU   B CD  1 
ATOM   7089 O  OE1 . GLU   B 2 288 ? -8.147  -18.159  -34.799 1.00 98.71  ? 289  GLU   B OE1 1 
ATOM   7090 O  OE2 . GLU   B 2 288 ? -7.988  -16.062  -34.179 1.00 102.53 ? 289  GLU   B OE2 1 
ATOM   7091 N  N   . LEU   B 2 289 ? -10.369 -14.106  -38.803 1.00 106.22 ? 290  LEU   B N   1 
ATOM   7092 C  CA  . LEU   B 2 289 ? -10.797 -12.682  -38.729 1.00 107.31 ? 290  LEU   B CA  1 
ATOM   7093 C  C   . LEU   B 2 289 ? -11.237 -12.363  -37.294 1.00 106.27 ? 290  LEU   B C   1 
ATOM   7094 O  O   . LEU   B 2 289 ? -10.603 -11.488  -36.674 1.00 107.50 ? 290  LEU   B O   1 
ATOM   7095 C  CB  . LEU   B 2 289 ? -11.930 -12.428  -39.731 1.00 109.32 ? 290  LEU   B CB  1 
ATOM   7096 C  CG  . LEU   B 2 289 ? -11.619 -12.752  -41.194 1.00 110.53 ? 290  LEU   B CG  1 
ATOM   7097 C  CD1 . LEU   B 2 289 ? -12.861 -12.600  -42.060 1.00 108.05 ? 290  LEU   B CD1 1 
ATOM   7098 C  CD2 . LEU   B 2 289 ? -10.491 -11.881  -41.729 1.00 112.57 ? 290  LEU   B CD2 1 
ATOM   7099 N  N   . PHE   B 2 290 ? -12.268 -13.054  -36.789 1.00 102.61 ? 291  PHE   B N   1 
ATOM   7100 C  CA  . PHE   B 2 290 ? -12.859 -12.843  -35.439 1.00 100.23 ? 291  PHE   B CA  1 
ATOM   7101 C  C   . PHE   B 2 290 ? -12.582 -14.060  -34.544 1.00 99.66  ? 291  PHE   B C   1 
ATOM   7102 O  O   . PHE   B 2 290 ? -12.206 -15.137  -35.051 1.00 96.18  ? 291  PHE   B O   1 
ATOM   7103 C  CB  . PHE   B 2 290 ? -14.359 -12.547  -35.552 1.00 98.46  ? 291  PHE   B CB  1 
ATOM   7104 C  CG  . PHE   B 2 290 ? -14.990 -11.928  -34.327 1.00 98.12  ? 291  PHE   B CG  1 
ATOM   7105 C  CD1 . PHE   B 2 290 ? -14.469 -10.772  -33.763 1.00 96.57  ? 291  PHE   B CD1 1 
ATOM   7106 C  CD2 . PHE   B 2 290 ? -16.120 -12.488  -33.747 1.00 96.87  ? 291  PHE   B CD2 1 
ATOM   7107 C  CE1 . PHE   B 2 290 ? -15.055 -10.201  -32.642 1.00 96.78  ? 291  PHE   B CE1 1 
ATOM   7108 C  CE2 . PHE   B 2 290 ? -16.704 -11.915  -32.627 1.00 95.96  ? 291  PHE   B CE2 1 
ATOM   7109 C  CZ  . PHE   B 2 290 ? -16.170 -10.774  -32.076 1.00 95.59  ? 291  PHE   B CZ  1 
ATOM   7110 N  N   . ARG   B 2 291 ? -12.754 -13.859  -33.233 1.00 102.19 ? 292  ARG   B N   1 
ATOM   7111 C  CA  . ARG   B 2 291 ? -12.600 -14.860  -32.141 1.00 98.51  ? 292  ARG   B CA  1 
ATOM   7112 C  C   . ARG   B 2 291 ? -13.558 -14.481  -31.008 1.00 96.25  ? 292  ARG   B C   1 
ATOM   7113 O  O   . ARG   B 2 291 ? -13.902 -13.287  -30.920 1.00 102.46 ? 292  ARG   B O   1 
ATOM   7114 C  CB  . ARG   B 2 291 ? -11.161 -14.853  -31.620 1.00 98.40  ? 292  ARG   B CB  1 
ATOM   7115 C  CG  . ARG   B 2 291 ? -10.325 -16.039  -32.067 1.00 100.04 ? 292  ARG   B CG  1 
ATOM   7116 C  CD  . ARG   B 2 291 ? -10.488 -17.232  -31.146 1.00 98.37  ? 292  ARG   B CD  1 
ATOM   7117 N  NE  . ARG   B 2 291 ? -9.708  -18.357  -31.646 1.00 97.50  ? 292  ARG   B NE  1 
ATOM   7118 C  CZ  . ARG   B 2 291 ? -10.196 -19.399  -32.312 1.00 93.61  ? 292  ARG   B CZ  1 
ATOM   7119 N  NH1 . ARG   B 2 291 ? -9.378  -20.352  -32.727 1.00 92.12  ? 292  ARG   B NH1 1 
ATOM   7120 N  NH2 . ARG   B 2 291 ? -11.491 -19.505  -32.555 1.00 94.15  ? 292  ARG   B NH2 1 
ATOM   7121 N  N   . SER   B 2 292 ? -13.964 -15.431  -30.161 1.00 97.16  ? 293  SER   B N   1 
ATOM   7122 C  CA  . SER   B 2 292 ? -14.853 -15.136  -29.006 1.00 95.70  ? 293  SER   B CA  1 
ATOM   7123 C  C   . SER   B 2 292 ? -14.792 -16.234  -27.936 1.00 96.42  ? 293  SER   B C   1 
ATOM   7124 O  O   . SER   B 2 292 ? -15.343 -17.327  -28.170 1.00 97.98  ? 293  SER   B O   1 
ATOM   7125 C  CB  . SER   B 2 292 ? -16.264 -14.893  -29.466 1.00 94.24  ? 293  SER   B CB  1 
ATOM   7126 O  OG  . SER   B 2 292 ? -16.935 -14.053  -28.543 1.00 95.50  ? 293  SER   B OG  1 
ATOM   7127 N  N   . GLN   B 2 293 ? -14.190 -15.909  -26.786 1.00 95.17  ? 294  GLN   B N   1 
ATOM   7128 C  CA  . GLN   B 2 293 ? -14.218 -16.721  -25.538 1.00 97.72  ? 294  GLN   B CA  1 
ATOM   7129 C  C   . GLN   B 2 293 ? -15.483 -16.387  -24.732 1.00 95.78  ? 294  GLN   B C   1 
ATOM   7130 O  O   . GLN   B 2 293 ? -15.554 -16.796  -23.556 1.00 97.10  ? 294  GLN   B O   1 
ATOM   7131 C  CB  . GLN   B 2 293 ? -12.954 -16.466  -24.708 1.00 103.65 ? 294  GLN   B CB  1 
ATOM   7132 C  CG  . GLN   B 2 293 ? -11.964 -17.624  -24.716 1.00 108.91 ? 294  GLN   B CG  1 
ATOM   7133 C  CD  . GLN   B 2 293 ? -11.399 -17.904  -26.087 1.00 110.77 ? 294  GLN   B CD  1 
ATOM   7134 O  OE1 . GLN   B 2 293 ? -11.302 -17.017  -26.932 1.00 114.55 ? 294  GLN   B OE1 1 
ATOM   7135 N  NE2 . GLN   B 2 293 ? -11.016 -19.150  -26.320 1.00 112.10 ? 294  GLN   B NE2 1 
ATOM   7136 N  N   . ALA   B 2 294 ? -16.446 -15.684  -25.343 1.00 92.56  ? 295  ALA   B N   1 
ATOM   7137 C  CA  . ALA   B 2 294 ? -17.700 -15.200  -24.717 1.00 90.58  ? 295  ALA   B CA  1 
ATOM   7138 C  C   . ALA   B 2 294 ? -18.391 -16.338  -23.958 1.00 88.49  ? 295  ALA   B C   1 
ATOM   7139 O  O   . ALA   B 2 294 ? -18.887 -16.096  -22.838 1.00 88.40  ? 295  ALA   B O   1 
ATOM   7140 C  CB  . ALA   B 2 294 ? -18.613 -14.627  -25.773 1.00 91.70  ? 295  ALA   B CB  1 
ATOM   7141 N  N   . HIS   B 2 295 ? -18.431 -17.531  -24.552 1.00 86.48  ? 296  HIS   B N   1 
ATOM   7142 C  CA  . HIS   B 2 295 ? -19.103 -18.724  -23.975 1.00 83.76  ? 296  HIS   B CA  1 
ATOM   7143 C  C   . HIS   B 2 295 ? -18.199 -19.369  -22.916 1.00 84.60  ? 296  HIS   B C   1 
ATOM   7144 O  O   . HIS   B 2 295 ? -16.955 -19.339  -23.083 1.00 78.63  ? 296  HIS   B O   1 
ATOM   7145 C  CB  . HIS   B 2 295 ? -19.522 -19.692  -25.088 1.00 81.42  ? 296  HIS   B CB  1 
ATOM   7146 C  CG  . HIS   B 2 295 ? -20.793 -19.302  -25.759 1.00 80.37  ? 296  HIS   B CG  1 
ATOM   7147 N  ND1 . HIS   B 2 295 ? -22.021 -19.458  -25.150 1.00 80.39  ? 296  HIS   B ND1 1 
ATOM   7148 C  CD2 . HIS   B 2 295 ? -21.036 -18.765  -26.974 1.00 81.82  ? 296  HIS   B CD2 1 
ATOM   7149 C  CE1 . HIS   B 2 295 ? -22.969 -19.039  -25.963 1.00 81.44  ? 296  HIS   B CE1 1 
ATOM   7150 N  NE2 . HIS   B 2 295 ? -22.391 -18.608  -27.089 1.00 81.86  ? 296  HIS   B NE2 1 
ATOM   7151 N  N   . ARG   B 2 296 ? -18.816 -19.912  -21.860 1.00 85.15  ? 297  ARG   B N   1 
ATOM   7152 C  CA  . ARG   B 2 296 ? -18.132 -20.586  -20.723 1.00 87.82  ? 297  ARG   B CA  1 
ATOM   7153 C  C   . ARG   B 2 296 ? -18.410 -22.097  -20.747 1.00 83.36  ? 297  ARG   B C   1 
ATOM   7154 O  O   . ARG   B 2 296 ? -17.855 -22.799  -19.888 1.00 82.07  ? 297  ARG   B O   1 
ATOM   7155 C  CB  . ARG   B 2 296 ? -18.574 -19.945  -19.404 1.00 90.20  ? 297  ARG   B CB  1 
ATOM   7156 C  CG  . ARG   B 2 296 ? -17.788 -18.694  -19.036 1.00 94.03  ? 297  ARG   B CG  1 
ATOM   7157 C  CD  . ARG   B 2 296 ? -18.362 -17.947  -17.846 1.00 96.87  ? 297  ARG   B CD  1 
ATOM   7158 N  NE  . ARG   B 2 296 ? -19.644 -17.326  -18.161 1.00 100.77 ? 297  ARG   B NE  1 
ATOM   7159 C  CZ  . ARG   B 2 296 ? -20.846 -17.876  -17.970 1.00 104.66 ? 297  ARG   B CZ  1 
ATOM   7160 N  NH1 . ARG   B 2 296 ? -21.933 -17.202  -18.311 1.00 103.49 ? 297  ARG   B NH1 1 
ATOM   7161 N  NH2 . ARG   B 2 296 ? -20.970 -19.087  -17.448 1.00 104.68 ? 297  ARG   B NH2 1 
ATOM   7162 N  N   . ASP   B 2 297 ? -19.233 -22.573  -21.688 1.00 82.72  ? 298  ASP   B N   1 
ATOM   7163 C  CA  . ASP   B 2 297 ? -19.489 -24.016  -21.952 1.00 79.91  ? 298  ASP   B CA  1 
ATOM   7164 C  C   . ASP   B 2 297 ? -19.455 -24.224  -23.471 1.00 77.59  ? 298  ASP   B C   1 
ATOM   7165 O  O   . ASP   B 2 297 ? -19.059 -23.275  -24.175 1.00 77.34  ? 298  ASP   B O   1 
ATOM   7166 C  CB  . ASP   B 2 297 ? -20.808 -24.465  -21.314 1.00 79.86  ? 298  ASP   B CB  1 
ATOM   7167 C  CG  . ASP   B 2 297 ? -20.814 -25.907  -20.830 1.00 81.87  ? 298  ASP   B CG  1 
ATOM   7168 O  OD1 . ASP   B 2 297 ? -20.047 -26.721  -21.387 1.00 84.23  ? 298  ASP   B OD1 1 
ATOM   7169 O  OD2 . ASP   B 2 297 ? -21.590 -26.207  -19.898 1.00 81.16  ? 298  ASP   B OD2 1 
ATOM   7170 N  N   . PHE   B 2 298 ? -19.838 -25.409  -23.959 1.00 75.96  ? 299  PHE   B N   1 
ATOM   7171 C  CA  . PHE   B 2 298 ? -19.810 -25.771  -25.402 1.00 75.07  ? 299  PHE   B CA  1 
ATOM   7172 C  C   . PHE   B 2 298 ? -20.683 -24.800  -26.202 1.00 74.08  ? 299  PHE   B C   1 
ATOM   7173 O  O   . PHE   B 2 298 ? -21.757 -24.418  -25.707 1.00 76.06  ? 299  PHE   B O   1 
ATOM   7174 C  CB  . PHE   B 2 298 ? -20.297 -27.203  -25.642 1.00 74.19  ? 299  PHE   B CB  1 
ATOM   7175 C  CG  . PHE   B 2 298 ? -19.437 -28.302  -25.067 1.00 73.03  ? 299  PHE   B CG  1 
ATOM   7176 C  CD1 . PHE   B 2 298 ? -18.126 -28.072  -24.671 1.00 71.53  ? 299  PHE   B CD1 1 
ATOM   7177 C  CD2 . PHE   B 2 298 ? -19.940 -29.588  -24.952 1.00 74.39  ? 299  PHE   B CD2 1 
ATOM   7178 C  CE1 . PHE   B 2 298 ? -17.351 -29.097  -24.150 1.00 72.00  ? 299  PHE   B CE1 1 
ATOM   7179 C  CE2 . PHE   B 2 298 ? -19.161 -30.613  -24.438 1.00 73.40  ? 299  PHE   B CE2 1 
ATOM   7180 C  CZ  . PHE   B 2 298 ? -17.868 -30.366  -24.038 1.00 71.87  ? 299  PHE   B CZ  1 
ATOM   7181 N  N   . VAL   B 2 299 ? -20.214 -24.429  -27.399 1.00 73.22  ? 300  VAL   B N   1 
ATOM   7182 C  CA  . VAL   B 2 299 ? -20.945 -23.616  -28.417 1.00 71.16  ? 300  VAL   B CA  1 
ATOM   7183 C  C   . VAL   B 2 299 ? -21.643 -24.591  -29.372 1.00 72.19  ? 300  VAL   B C   1 
ATOM   7184 O  O   . VAL   B 2 299 ? -20.940 -25.439  -29.952 1.00 81.53  ? 300  VAL   B O   1 
ATOM   7185 C  CB  . VAL   B 2 299 ? -19.985 -22.681  -29.177 1.00 71.91  ? 300  VAL   B CB  1 
ATOM   7186 C  CG1 . VAL   B 2 299 ? -20.736 -21.710  -30.075 1.00 73.54  ? 300  VAL   B CG1 1 
ATOM   7187 C  CG2 . VAL   B 2 299 ? -19.055 -21.928  -28.236 1.00 70.41  ? 300  VAL   B CG2 1 
ATOM   7188 N  N   . ARG   B 2 300 ? -22.963 -24.468  -29.538 1.00 69.77  ? 301  ARG   B N   1 
ATOM   7189 C  CA  . ARG   B 2 300 ? -23.824 -25.514  -30.156 1.00 71.66  ? 301  ARG   B CA  1 
ATOM   7190 C  C   . ARG   B 2 300 ? -24.433 -25.047  -31.488 1.00 72.91  ? 301  ARG   B C   1 
ATOM   7191 O  O   . ARG   B 2 300 ? -24.734 -25.929  -32.323 1.00 72.68  ? 301  ARG   B O   1 
ATOM   7192 C  CB  . ARG   B 2 300 ? -24.897 -25.938  -29.150 1.00 72.47  ? 301  ARG   B CB  1 
ATOM   7193 C  CG  . ARG   B 2 300 ? -24.339 -26.313  -27.783 1.00 75.29  ? 301  ARG   B CG  1 
ATOM   7194 C  CD  . ARG   B 2 300 ? -23.245 -27.368  -27.842 1.00 73.46  ? 301  ARG   B CD  1 
ATOM   7195 N  NE  . ARG   B 2 300 ? -23.744 -28.618  -28.398 1.00 73.54  ? 301  ARG   B NE  1 
ATOM   7196 C  CZ  . ARG   B 2 300 ? -22.988 -29.622  -28.838 1.00 70.57  ? 301  ARG   B CZ  1 
ATOM   7197 N  NH1 . ARG   B 2 300 ? -21.669 -29.536  -28.807 1.00 70.58  ? 301  ARG   B NH1 1 
ATOM   7198 N  NH2 . ARG   B 2 300 ? -23.564 -30.711  -29.322 1.00 67.98  ? 301  ARG   B NH2 1 
ATOM   7199 N  N   . ASP   B 2 301 ? -24.615 -23.739  -31.700 1.00 74.43  ? 302  ASP   B N   1 
ATOM   7200 C  CA  . ASP   B 2 301 ? -25.061 -23.196  -33.012 1.00 74.44  ? 302  ASP   B CA  1 
ATOM   7201 C  C   . ASP   B 2 301 ? -24.504 -21.787  -33.245 1.00 79.03  ? 302  ASP   B C   1 
ATOM   7202 O  O   . ASP   B 2 301 ? -24.087 -21.125  -32.273 1.00 79.26  ? 302  ASP   B O   1 
ATOM   7203 C  CB  . ASP   B 2 301 ? -26.585 -23.183  -33.128 1.00 73.61  ? 302  ASP   B CB  1 
ATOM   7204 C  CG  . ASP   B 2 301 ? -27.087 -23.659  -34.479 1.00 71.72  ? 302  ASP   B CG  1 
ATOM   7205 O  OD1 . ASP   B 2 301 ? -26.293 -23.649  -35.439 1.00 70.63  ? 302  ASP   B OD1 1 
ATOM   7206 O  OD2 . ASP   B 2 301 ? -28.259 -24.064  -34.550 1.00 71.75  ? 302  ASP   B OD2 1 
ATOM   7207 N  N   . ALA   B 2 302 ? -24.478 -21.382  -34.515 1.00 83.70  ? 303  ALA   B N   1 
ATOM   7208 C  CA  . ALA   B 2 302 ? -24.303 -19.989  -34.985 1.00 87.77  ? 303  ALA   B CA  1 
ATOM   7209 C  C   . ALA   B 2 302 ? -25.336 -19.717  -36.087 1.00 90.50  ? 303  ALA   B C   1 
ATOM   7210 O  O   . ALA   B 2 302 ? -25.575 -20.622  -36.920 1.00 90.68  ? 303  ALA   B O   1 
ATOM   7211 C  CB  . ALA   B 2 302 ? -22.890 -19.776  -35.470 1.00 89.06  ? 303  ALA   B CB  1 
ATOM   7212 N  N   . THR   B 2 303 ? -25.959 -18.537  -36.063 1.00 88.29  ? 304  THR   B N   1 
ATOM   7213 C  CA  . THR   B 2 303 ? -26.933 -18.073  -37.087 1.00 86.15  ? 304  THR   B CA  1 
ATOM   7214 C  C   . THR   B 2 303 ? -26.682 -16.582  -37.331 1.00 86.57  ? 304  THR   B C   1 
ATOM   7215 O  O   . THR   B 2 303 ? -26.621 -15.819  -36.343 1.00 80.48  ? 304  THR   B O   1 
ATOM   7216 C  CB  . THR   B 2 303 ? -28.368 -18.450  -36.683 1.00 87.44  ? 304  THR   B CB  1 
ATOM   7217 O  OG1 . THR   B 2 303 ? -29.251 -18.151  -37.765 1.00 83.92  ? 304  THR   B OG1 1 
ATOM   7218 C  CG2 . THR   B 2 303 ? -28.848 -17.762  -35.424 1.00 86.98  ? 304  THR   B CG2 1 
ATOM   7219 N  N   . TRP   B 2 304 ? -26.480 -16.209  -38.600 1.00 91.54  ? 305  TRP   B N   1 
ATOM   7220 C  CA  . TRP   B 2 304 ? -26.239 -14.815  -39.061 1.00 88.82  ? 305  TRP   B CA  1 
ATOM   7221 C  C   . TRP   B 2 304 ? -27.583 -14.103  -39.232 1.00 91.00  ? 305  TRP   B C   1 
ATOM   7222 O  O   . TRP   B 2 304 ? -28.495 -14.714  -39.834 1.00 86.49  ? 305  TRP   B O   1 
ATOM   7223 C  CB  . TRP   B 2 304 ? -25.461 -14.806  -40.379 1.00 86.95  ? 305  TRP   B CB  1 
ATOM   7224 C  CG  . TRP   B 2 304 ? -24.153 -15.533  -40.345 1.00 84.26  ? 305  TRP   B CG  1 
ATOM   7225 C  CD1 . TRP   B 2 304 ? -23.956 -16.877  -40.470 1.00 81.57  ? 305  TRP   B CD1 1 
ATOM   7226 C  CD2 . TRP   B 2 304 ? -22.847 -14.945  -40.220 1.00 80.12  ? 305  TRP   B CD2 1 
ATOM   7227 N  NE1 . TRP   B 2 304 ? -22.621 -17.166  -40.412 1.00 83.97  ? 305  TRP   B NE1 1 
ATOM   7228 C  CE2 . TRP   B 2 304 ? -21.914 -16.003  -40.255 1.00 81.30  ? 305  TRP   B CE2 1 
ATOM   7229 C  CE3 . TRP   B 2 304 ? -22.375 -13.638  -40.065 1.00 81.68  ? 305  TRP   B CE3 1 
ATOM   7230 C  CZ2 . TRP   B 2 304 ? -20.540 -15.789  -40.147 1.00 82.62  ? 305  TRP   B CZ2 1 
ATOM   7231 C  CZ3 . TRP   B 2 304 ? -21.017 -13.427  -39.959 1.00 83.43  ? 305  TRP   B CZ3 1 
ATOM   7232 C  CH2 . TRP   B 2 304 ? -20.113 -14.489  -40.000 1.00 82.83  ? 305  TRP   B CH2 1 
ATOM   7233 N  N   . SER   B 2 305 ? -27.697 -12.867  -38.734 1.00 96.20  ? 306  SER   B N   1 
ATOM   7234 C  CA  . SER   B 2 305 ? -28.899 -12.006  -38.897 1.00 99.15  ? 306  SER   B CA  1 
ATOM   7235 C  C   . SER   B 2 305 ? -29.135 -11.758  -40.387 1.00 98.01  ? 306  SER   B C   1 
ATOM   7236 O  O   . SER   B 2 305 ? -28.212 -11.365  -41.101 1.00 92.84  ? 306  SER   B O   1 
ATOM   7237 C  CB  . SER   B 2 305 ? -28.764 -10.711  -38.134 1.00 99.95  ? 306  SER   B CB  1 
ATOM   7238 O  OG  . SER   B 2 305 ? -29.999 -10.009  -38.095 1.00 101.43 ? 306  SER   B OG  1 
ATOM   7239 N  N   . PRO   B 2 306 ? -30.364 -11.998  -40.906 1.00 97.36  ? 307  PRO   B N   1 
ATOM   7240 C  CA  . PRO   B 2 306 ? -30.686 -11.667  -42.293 1.00 98.19  ? 307  PRO   B CA  1 
ATOM   7241 C  C   . PRO   B 2 306 ? -30.667 -10.144  -42.494 1.00 99.48  ? 307  PRO   B C   1 
ATOM   7242 O  O   . PRO   B 2 306 ? -30.256 -9.697   -43.550 1.00 98.16  ? 307  PRO   B O   1 
ATOM   7243 C  CB  . PRO   B 2 306 ? -32.104 -12.212  -42.537 1.00 98.99  ? 307  PRO   B CB  1 
ATOM   7244 C  CG  . PRO   B 2 306 ? -32.483 -12.977  -41.276 1.00 98.07  ? 307  PRO   B CG  1 
ATOM   7245 C  CD  . PRO   B 2 306 ? -31.514 -12.564  -40.187 1.00 96.62  ? 307  PRO   B CD  1 
ATOM   7246 N  N   . LEU   B 2 307 ? -31.076 -9.404   -41.455 1.00 98.76  ? 308  LEU   B N   1 
ATOM   7247 C  CA  . LEU   B 2 307 ? -31.338 -7.940   -41.479 1.00 97.49  ? 308  LEU   B CA  1 
ATOM   7248 C  C   . LEU   B 2 307 ? -30.010 -7.175   -41.434 1.00 99.06  ? 308  LEU   B C   1 
ATOM   7249 O  O   . LEU   B 2 307 ? -29.875 -6.189   -42.189 1.00 99.66  ? 308  LEU   B O   1 
ATOM   7250 C  CB  . LEU   B 2 307 ? -32.237 -7.575   -40.292 1.00 94.00  ? 308  LEU   B CB  1 
ATOM   7251 C  CG  . LEU   B 2 307 ? -33.460 -8.472   -40.083 1.00 95.74  ? 308  LEU   B CG  1 
ATOM   7252 C  CD1 . LEU   B 2 307 ? -34.401 -7.876   -39.045 1.00 94.99  ? 308  LEU   B CD1 1 
ATOM   7253 C  CD2 . LEU   B 2 307 ? -34.197 -8.719   -41.393 1.00 97.22  ? 308  LEU   B CD2 1 
ATOM   7254 N  N   . ASN   B 2 308 ? -29.074 -7.611   -40.585 1.00 99.26  ? 309  ASN   B N   1 
ATOM   7255 C  CA  . ASN   B 2 308 ? -27.710 -7.027   -40.472 1.00 102.19 ? 309  ASN   B CA  1 
ATOM   7256 C  C   . ASN   B 2 308 ? -26.672 -8.150   -40.591 1.00 107.07 ? 309  ASN   B C   1 
ATOM   7257 O  O   . ASN   B 2 308 ? -26.484 -8.888   -39.606 1.00 110.55 ? 309  ASN   B O   1 
ATOM   7258 C  CB  . ASN   B 2 308 ? -27.548 -6.232   -39.174 1.00 102.08 ? 309  ASN   B CB  1 
ATOM   7259 C  CG  . ASN   B 2 308 ? -26.193 -5.568   -39.047 1.00 104.59 ? 309  ASN   B CG  1 
ATOM   7260 O  OD1 . ASN   B 2 308 ? -25.382 -5.603   -39.972 1.00 106.97 ? 309  ASN   B OD1 1 
ATOM   7261 N  ND2 . ASN   B 2 308 ? -25.935 -4.957   -37.903 1.00 104.09 ? 309  ASN   B ND2 1 
ATOM   7262 N  N   . HIS   B 2 309 ? -25.998 -8.242   -41.742 1.00 111.27 ? 310  HIS   B N   1 
ATOM   7263 C  CA  . HIS   B 2 309 ? -25.007 -9.302   -42.075 1.00 112.05 ? 310  HIS   B CA  1 
ATOM   7264 C  C   . HIS   B 2 309 ? -23.769 -9.201   -41.170 1.00 110.58 ? 310  HIS   B C   1 
ATOM   7265 O  O   . HIS   B 2 309 ? -22.984 -10.167  -41.156 1.00 108.29 ? 310  HIS   B O   1 
ATOM   7266 C  CB  . HIS   B 2 309 ? -24.623 -9.239   -43.560 1.00 116.55 ? 310  HIS   B CB  1 
ATOM   7267 C  CG  . HIS   B 2 309 ? -25.770 -9.428   -44.495 1.00 119.92 ? 310  HIS   B CG  1 
ATOM   7268 N  ND1 . HIS   B 2 309 ? -26.729 -10.404  -44.301 1.00 121.09 ? 310  HIS   B ND1 1 
ATOM   7269 C  CD2 . HIS   B 2 309 ? -26.104 -8.788   -45.637 1.00 122.00 ? 310  HIS   B CD2 1 
ATOM   7270 C  CE1 . HIS   B 2 309 ? -27.615 -10.346  -45.275 1.00 119.74 ? 310  HIS   B CE1 1 
ATOM   7271 N  NE2 . HIS   B 2 309 ? -27.252 -9.364   -46.109 1.00 122.93 ? 310  HIS   B NE2 1 
ATOM   7272 N  N   . SER   B 2 310 ? -23.592 -8.084   -40.454 1.00 110.04 ? 311  SER   B N   1 
ATOM   7273 C  CA  . SER   B 2 310 ? -22.500 -7.876   -39.464 1.00 114.48 ? 311  SER   B CA  1 
ATOM   7274 C  C   . SER   B 2 310 ? -22.770 -8.687   -38.189 1.00 116.57 ? 311  SER   B C   1 
ATOM   7275 O  O   . SER   B 2 310 ? -21.787 -9.110   -37.548 1.00 116.50 ? 311  SER   B O   1 
ATOM   7276 C  CB  . SER   B 2 310 ? -22.319 -6.413   -39.144 1.00 114.30 ? 311  SER   B CB  1 
ATOM   7277 O  OG  . SER   B 2 310 ? -21.826 -5.705   -40.271 1.00 115.44 ? 311  SER   B OG  1 
ATOM   7278 N  N   . LEU   B 2 311 ? -24.045 -8.888   -37.833 1.00 114.93 ? 312  LEU   B N   1 
ATOM   7279 C  CA  . LEU   B 2 311 ? -24.474 -9.564   -36.576 1.00 115.27 ? 312  LEU   B CA  1 
ATOM   7280 C  C   . LEU   B 2 311 ? -24.362 -11.087  -36.742 1.00 113.74 ? 312  LEU   B C   1 
ATOM   7281 O  O   . LEU   B 2 311 ? -24.604 -11.581  -37.863 1.00 114.57 ? 312  LEU   B O   1 
ATOM   7282 C  CB  . LEU   B 2 311 ? -25.910 -9.147   -36.237 1.00 117.06 ? 312  LEU   B CB  1 
ATOM   7283 C  CG  . LEU   B 2 311 ? -26.330 -9.352   -34.780 1.00 119.66 ? 312  LEU   B CG  1 
ATOM   7284 C  CD1 . LEU   B 2 311 ? -25.758 -8.257   -33.891 1.00 120.32 ? 312  LEU   B CD1 1 
ATOM   7285 C  CD2 . LEU   B 2 311 ? -27.845 -9.404   -34.642 1.00 120.87 ? 312  LEU   B CD2 1 
ATOM   7286 N  N   . LEU   B 2 312 ? -24.010 -11.792  -35.658 1.00 107.80 ? 313  LEU   B N   1 
ATOM   7287 C  CA  . LEU   B 2 312 ? -23.873 -13.276  -35.597 1.00 98.43  ? 313  LEU   B CA  1 
ATOM   7288 C  C   . LEU   B 2 312 ? -24.252 -13.757  -34.190 1.00 93.27  ? 313  LEU   B C   1 
ATOM   7289 O  O   . LEU   B 2 312 ? -23.521 -13.426  -33.243 1.00 91.73  ? 313  LEU   B O   1 
ATOM   7290 C  CB  . LEU   B 2 312 ? -22.430 -13.654  -35.948 1.00 95.54  ? 313  LEU   B CB  1 
ATOM   7291 C  CG  . LEU   B 2 312 ? -22.084 -15.141  -35.879 1.00 92.63  ? 313  LEU   B CG  1 
ATOM   7292 C  CD1 . LEU   B 2 312 ? -23.083 -15.977  -36.667 1.00 91.14  ? 313  LEU   B CD1 1 
ATOM   7293 C  CD2 . LEU   B 2 312 ? -20.667 -15.384  -36.381 1.00 89.43  ? 313  LEU   B CD2 1 
ATOM   7294 N  N   . THR   B 2 313 ? -25.355 -14.503  -34.069 1.00 89.99  ? 314  THR   B N   1 
ATOM   7295 C  CA  . THR   B 2 313 ? -25.933 -14.985  -32.785 1.00 91.11  ? 314  THR   B CA  1 
ATOM   7296 C  C   . THR   B 2 313 ? -25.462 -16.422  -32.519 1.00 90.62  ? 314  THR   B C   1 
ATOM   7297 O  O   . THR   B 2 313 ? -25.736 -17.290  -33.369 1.00 97.99  ? 314  THR   B O   1 
ATOM   7298 C  CB  . THR   B 2 313 ? -27.465 -14.883  -32.816 1.00 92.07  ? 314  THR   B CB  1 
ATOM   7299 O  OG1 . THR   B 2 313 ? -27.804 -13.507  -32.984 1.00 96.65  ? 314  THR   B OG1 1 
ATOM   7300 C  CG2 . THR   B 2 313 ? -28.137 -15.419  -31.570 1.00 92.91  ? 314  THR   B CG2 1 
ATOM   7301 N  N   . THR   B 2 314 ? -24.784 -16.659  -31.390 1.00 85.77  ? 315  THR   B N   1 
ATOM   7302 C  CA  . THR   B 2 314 ? -24.398 -18.011  -30.896 1.00 80.34  ? 315  THR   B CA  1 
ATOM   7303 C  C   . THR   B 2 314 ? -25.152 -18.350  -29.610 1.00 78.89  ? 315  THR   B C   1 
ATOM   7304 O  O   . THR   B 2 314 ? -25.390 -17.437  -28.801 1.00 78.41  ? 315  THR   B O   1 
ATOM   7305 C  CB  . THR   B 2 314 ? -22.904 -18.122  -30.574 1.00 78.81  ? 315  THR   B CB  1 
ATOM   7306 O  OG1 . THR   B 2 314 ? -22.596 -17.084  -29.643 1.00 76.71  ? 315  THR   B OG1 1 
ATOM   7307 C  CG2 . THR   B 2 314 ? -22.021 -18.030  -31.798 1.00 80.90  ? 315  THR   B CG2 1 
ATOM   7308 N  N   . VAL   B 2 315 ? -25.473 -19.630  -29.425 1.00 81.73  ? 316  VAL   B N   1 
ATOM   7309 C  CA  . VAL   B 2 315 ? -25.999 -20.192  -28.147 1.00 84.49  ? 316  VAL   B CA  1 
ATOM   7310 C  C   . VAL   B 2 315 ? -25.039 -21.291  -27.675 1.00 84.21  ? 316  VAL   B C   1 
ATOM   7311 O  O   . VAL   B 2 315 ? -24.371 -21.904  -28.533 1.00 77.70  ? 316  VAL   B O   1 
ATOM   7312 C  CB  . VAL   B 2 315 ? -27.442 -20.704  -28.311 1.00 84.33  ? 316  VAL   B CB  1 
ATOM   7313 C  CG1 . VAL   B 2 315 ? -28.347 -19.611  -28.856 1.00 83.80  ? 316  VAL   B CG1 1 
ATOM   7314 C  CG2 . VAL   B 2 315 ? -27.522 -21.951  -29.179 1.00 85.27  ? 316  VAL   B CG2 1 
ATOM   7315 N  N   . GLY   B 2 316 ? -24.962 -21.504  -26.357 1.00 85.82  ? 317  GLY   B N   1 
ATOM   7316 C  CA  . GLY   B 2 316 ? -24.124 -22.540  -25.722 1.00 85.80  ? 317  GLY   B CA  1 
ATOM   7317 C  C   . GLY   B 2 316 ? -24.894 -23.317  -24.669 1.00 82.81  ? 317  GLY   B C   1 
ATOM   7318 O  O   . GLY   B 2 316 ? -26.102 -23.063  -24.517 1.00 86.99  ? 317  GLY   B O   1 
ATOM   7319 N  N   . TRP   B 2 317 ? -24.226 -24.240  -23.973 1.00 80.36  ? 318  TRP   B N   1 
ATOM   7320 C  CA  . TRP   B 2 317 ? -24.793 -24.992  -22.820 1.00 77.79  ? 318  TRP   B CA  1 
ATOM   7321 C  C   . TRP   B 2 317 ? -24.666 -24.157  -21.539 1.00 72.20  ? 318  TRP   B C   1 
ATOM   7322 O  O   . TRP   B 2 317 ? -25.296 -24.524  -20.535 1.00 70.84  ? 318  TRP   B O   1 
ATOM   7323 C  CB  . TRP   B 2 317 ? -24.127 -26.366  -22.672 1.00 80.91  ? 318  TRP   B CB  1 
ATOM   7324 C  CG  . TRP   B 2 317 ? -24.574 -27.393  -23.669 1.00 82.31  ? 318  TRP   B CG  1 
ATOM   7325 C  CD1 . TRP   B 2 317 ? -25.583 -27.292  -24.585 1.00 78.36  ? 318  TRP   B CD1 1 
ATOM   7326 C  CD2 . TRP   B 2 317 ? -24.038 -28.720  -23.815 1.00 82.97  ? 318  TRP   B CD2 1 
ATOM   7327 N  NE1 . TRP   B 2 317 ? -25.695 -28.452  -25.303 1.00 77.70  ? 318  TRP   B NE1 1 
ATOM   7328 C  CE2 . TRP   B 2 317 ? -24.765 -29.350  -24.848 1.00 81.36  ? 318  TRP   B CE2 1 
ATOM   7329 C  CE3 . TRP   B 2 317 ? -23.016 -29.432  -23.174 1.00 79.54  ? 318  TRP   B CE3 1 
ATOM   7330 C  CZ2 . TRP   B 2 317 ? -24.495 -30.657  -25.254 1.00 79.31  ? 318  TRP   B CZ2 1 
ATOM   7331 C  CZ3 . TRP   B 2 317 ? -22.753 -30.723  -23.575 1.00 79.18  ? 318  TRP   B CZ3 1 
ATOM   7332 C  CH2 . TRP   B 2 317 ? -23.482 -31.323  -24.603 1.00 78.85  ? 318  TRP   B CH2 1 
ATOM   7333 N  N   . ASP   B 2 318 ? -23.896 -23.066  -21.585 1.00 69.98  ? 319  ASP   B N   1 
ATOM   7334 C  CA  . ASP   B 2 318 ? -23.831 -22.032  -20.518 1.00 70.94  ? 319  ASP   B CA  1 
ATOM   7335 C  C   . ASP   B 2 318 ? -25.138 -21.222  -20.482 1.00 71.19  ? 319  ASP   B C   1 
ATOM   7336 O  O   . ASP   B 2 318 ? -25.283 -20.398  -19.562 1.00 68.04  ? 319  ASP   B O   1 
ATOM   7337 C  CB  . ASP   B 2 318 ? -22.626 -21.107  -20.712 1.00 69.96  ? 319  ASP   B CB  1 
ATOM   7338 C  CG  . ASP   B 2 318 ? -22.645 -20.315  -22.008 1.00 70.42  ? 319  ASP   B CG  1 
ATOM   7339 O  OD1 . ASP   B 2 318 ? -23.519 -20.593  -22.864 1.00 68.88  ? 319  ASP   B OD1 1 
ATOM   7340 O  OD2 . ASP   B 2 318 ? -21.781 -19.433  -22.154 1.00 71.10  ? 319  ASP   B OD2 1 
ATOM   7341 N  N   . HIS   B 2 319 ? -26.033 -21.417  -21.459 1.00 74.95  ? 320  HIS   B N   1 
ATOM   7342 C  CA  . HIS   B 2 319 ? -27.391 -20.807  -21.517 1.00 78.09  ? 320  HIS   B CA  1 
ATOM   7343 C  C   . HIS   B 2 319 ? -27.295 -19.320  -21.880 1.00 77.15  ? 320  HIS   B C   1 
ATOM   7344 O  O   . HIS   B 2 319 ? -28.279 -18.598  -21.654 1.00 76.92  ? 320  HIS   B O   1 
ATOM   7345 C  CB  . HIS   B 2 319 ? -28.131 -21.019  -20.191 1.00 78.81  ? 320  HIS   B CB  1 
ATOM   7346 C  CG  . HIS   B 2 319 ? -29.612 -20.867  -20.285 1.00 81.78  ? 320  HIS   B CG  1 
ATOM   7347 N  ND1 . HIS   B 2 319 ? -30.428 -21.863  -20.786 1.00 83.89  ? 320  HIS   B ND1 1 
ATOM   7348 C  CD2 . HIS   B 2 319 ? -30.429 -19.854  -19.924 1.00 81.12  ? 320  HIS   B CD2 1 
ATOM   7349 C  CE1 . HIS   B 2 319 ? -31.683 -21.470  -20.732 1.00 82.22  ? 320  HIS   B CE1 1 
ATOM   7350 N  NE2 . HIS   B 2 319 ? -31.710 -20.240  -20.212 1.00 84.80  ? 320  HIS   B NE2 1 
ATOM   7351 N  N   . GLN   B 2 320 ? -26.152 -18.885  -22.418 1.00 78.82  ? 321  GLN   B N   1 
ATOM   7352 C  CA  . GLN   B 2 320 ? -25.954 -17.517  -22.960 1.00 80.26  ? 321  GLN   B CA  1 
ATOM   7353 C  C   . GLN   B 2 320 ? -26.467 -17.490  -24.404 1.00 82.11  ? 321  GLN   B C   1 
ATOM   7354 O  O   . GLN   B 2 320 ? -26.285 -18.498  -25.116 1.00 80.96  ? 321  GLN   B O   1 
ATOM   7355 C  CB  . GLN   B 2 320 ? -24.482 -17.106  -22.900 1.00 79.84  ? 321  GLN   B CB  1 
ATOM   7356 C  CG  . GLN   B 2 320 ? -24.015 -16.698  -21.512 1.00 82.53  ? 321  GLN   B CG  1 
ATOM   7357 C  CD  . GLN   B 2 320 ? -22.681 -15.992  -21.558 1.00 89.09  ? 321  GLN   B CD  1 
ATOM   7358 O  OE1 . GLN   B 2 320 ? -22.579 -14.803  -21.259 1.00 93.75  ? 321  GLN   B OE1 1 
ATOM   7359 N  NE2 . GLN   B 2 320 ? -21.645 -16.719  -21.950 1.00 86.69  ? 321  GLN   B NE2 1 
ATOM   7360 N  N   . VAL   B 2 321 ? -27.117 -16.391  -24.796 1.00 81.74  ? 322  VAL   B N   1 
ATOM   7361 C  CA  . VAL   B 2 321 ? -27.426 -16.050  -26.215 1.00 77.16  ? 322  VAL   B CA  1 
ATOM   7362 C  C   . VAL   B 2 321 ? -26.590 -14.815  -26.561 1.00 77.77  ? 322  VAL   B C   1 
ATOM   7363 O  O   . VAL   B 2 321 ? -27.074 -13.691  -26.340 1.00 82.98  ? 322  VAL   B O   1 
ATOM   7364 C  CB  . VAL   B 2 321 ? -28.934 -15.824  -26.439 1.00 74.65  ? 322  VAL   B CB  1 
ATOM   7365 C  CG1 . VAL   B 2 321 ? -29.243 -15.477  -27.886 1.00 77.08  ? 322  VAL   B CG1 1 
ATOM   7366 C  CG2 . VAL   B 2 321 ? -29.754 -17.027  -26.001 1.00 74.23  ? 322  VAL   B CG2 1 
ATOM   7367 N  N   . VAL   B 2 322 ? -25.360 -15.029  -27.034 1.00 79.60  ? 323  VAL   B N   1 
ATOM   7368 C  CA  . VAL   B 2 322 ? -24.370 -13.950  -27.319 1.00 80.93  ? 323  VAL   B CA  1 
ATOM   7369 C  C   . VAL   B 2 322 ? -24.591 -13.463  -28.753 1.00 85.31  ? 323  VAL   B C   1 
ATOM   7370 O  O   . VAL   B 2 322 ? -24.499 -14.294  -29.679 1.00 89.61  ? 323  VAL   B O   1 
ATOM   7371 C  CB  . VAL   B 2 322 ? -22.917 -14.420  -27.116 1.00 81.78  ? 323  VAL   B CB  1 
ATOM   7372 C  CG1 . VAL   B 2 322 ? -21.937 -13.264  -27.255 1.00 80.85  ? 323  VAL   B CG1 1 
ATOM   7373 C  CG2 . VAL   B 2 322 ? -22.719 -15.127  -25.782 1.00 83.33  ? 323  VAL   B CG2 1 
ATOM   7374 N  N   . HIS   B 2 323 ? -24.878 -12.168  -28.912 1.00 88.75  ? 324  HIS   B N   1 
ATOM   7375 C  CA  . HIS   B 2 323 ? -24.956 -11.461  -30.217 1.00 84.61  ? 324  HIS   B CA  1 
ATOM   7376 C  C   . HIS   B 2 323 ? -23.584 -10.846  -30.507 1.00 83.15  ? 324  HIS   B C   1 
ATOM   7377 O  O   . HIS   B 2 323 ? -23.209 -9.888   -29.803 1.00 79.77  ? 324  HIS   B O   1 
ATOM   7378 C  CB  . HIS   B 2 323 ? -26.085 -10.423  -30.204 1.00 82.00  ? 324  HIS   B CB  1 
ATOM   7379 C  CG  . HIS   B 2 323 ? -27.399 -10.982  -29.774 1.00 79.09  ? 324  HIS   B CG  1 
ATOM   7380 N  ND1 . HIS   B 2 323 ? -28.140 -11.826  -30.579 1.00 77.29  ? 324  HIS   B ND1 1 
ATOM   7381 C  CD2 . HIS   B 2 323 ? -28.102 -10.831  -28.631 1.00 79.43  ? 324  HIS   B CD2 1 
ATOM   7382 C  CE1 . HIS   B 2 323 ? -29.248 -12.168  -29.950 1.00 79.36  ? 324  HIS   B CE1 1 
ATOM   7383 N  NE2 . HIS   B 2 323 ? -29.248 -11.570  -28.751 1.00 79.88  ? 324  HIS   B NE2 1 
ATOM   7384 N  N   . HIS   B 2 324 ? -22.855 -11.419  -31.469 1.00 85.21  ? 325  HIS   B N   1 
ATOM   7385 C  CA  . HIS   B 2 324 ? -21.521 -10.947  -31.925 1.00 89.76  ? 325  HIS   B CA  1 
ATOM   7386 C  C   . HIS   B 2 324 ? -21.710 -9.959   -33.079 1.00 92.48  ? 325  HIS   B C   1 
ATOM   7387 O  O   . HIS   B 2 324 ? -22.627 -10.169  -33.899 1.00 86.88  ? 325  HIS   B O   1 
ATOM   7388 C  CB  . HIS   B 2 324 ? -20.623 -12.122  -32.348 1.00 90.58  ? 325  HIS   B CB  1 
ATOM   7389 C  CG  . HIS   B 2 324 ? -20.504 -13.203  -31.326 1.00 89.00  ? 325  HIS   B CG  1 
ATOM   7390 N  ND1 . HIS   B 2 324 ? -19.477 -13.241  -30.403 1.00 86.20  ? 325  HIS   B ND1 1 
ATOM   7391 C  CD2 . HIS   B 2 324 ? -21.278 -14.281  -31.079 1.00 86.79  ? 325  HIS   B CD2 1 
ATOM   7392 C  CE1 . HIS   B 2 324 ? -19.628 -14.298  -29.631 1.00 84.79  ? 325  HIS   B CE1 1 
ATOM   7393 N  NE2 . HIS   B 2 324 ? -20.723 -14.950  -30.025 1.00 86.39  ? 325  HIS   B NE2 1 
ATOM   7394 N  N   . VAL   B 2 325 ? -20.866 -8.927   -33.128 1.00 96.26  ? 326  VAL   B N   1 
ATOM   7395 C  CA  . VAL   B 2 325 ? -20.767 -7.974   -34.270 1.00 100.90 ? 326  VAL   B CA  1 
ATOM   7396 C  C   . VAL   B 2 325 ? -19.430 -8.250   -34.966 1.00 101.82 ? 326  VAL   B C   1 
ATOM   7397 O  O   . VAL   B 2 325 ? -18.373 -7.898   -34.403 1.00 99.07  ? 326  VAL   B O   1 
ATOM   7398 C  CB  . VAL   B 2 325 ? -20.938 -6.507   -33.820 1.00 102.86 ? 326  VAL   B CB  1 
ATOM   7399 C  CG1 . VAL   B 2 325 ? -22.346 -6.255   -33.298 1.00 99.87  ? 326  VAL   B CG1 1 
ATOM   7400 C  CG2 . VAL   B 2 325 ? -19.907 -6.069   -32.786 1.00 105.26 ? 326  VAL   B CG2 1 
ATOM   7401 N  N   . VAL   B 2 326 ? -19.483 -8.920   -36.120 1.00 106.00 ? 327  VAL   B N   1 
ATOM   7402 C  CA  . VAL   B 2 326 ? -18.284 -9.333   -36.907 1.00 111.22 ? 327  VAL   B CA  1 
ATOM   7403 C  C   . VAL   B 2 326 ? -17.698 -8.071   -37.536 1.00 115.55 ? 327  VAL   B C   1 
ATOM   7404 O  O   . VAL   B 2 326 ? -18.449 -7.232   -38.027 1.00 118.41 ? 327  VAL   B O   1 
ATOM   7405 C  CB  . VAL   B 2 326 ? -18.633 -10.399  -37.968 1.00 111.79 ? 327  VAL   B CB  1 
ATOM   7406 C  CG1 . VAL   B 2 326 ? -17.394 -10.935  -38.672 1.00 110.84 ? 327  VAL   B CG1 1 
ATOM   7407 C  CG2 . VAL   B 2 326 ? -19.438 -11.551  -37.385 1.00 110.41 ? 327  VAL   B CG2 1 
ATOM   7408 N  N   . PRO   B 2 327 ? -16.355 -7.888   -37.530 1.00 122.81 ? 328  PRO   B N   1 
ATOM   7409 C  CA  . PRO   B 2 327 ? -15.728 -6.683   -38.084 1.00 128.32 ? 328  PRO   B CA  1 
ATOM   7410 C  C   . PRO   B 2 327 ? -15.986 -6.460   -39.585 1.00 136.50 ? 328  PRO   B C   1 
ATOM   7411 O  O   . PRO   B 2 327 ? -16.068 -5.310   -39.987 1.00 144.45 ? 328  PRO   B O   1 
ATOM   7412 C  CB  . PRO   B 2 327 ? -14.226 -6.907   -37.838 1.00 126.92 ? 328  PRO   B CB  1 
ATOM   7413 C  CG  . PRO   B 2 327 ? -14.092 -8.407   -37.706 1.00 125.84 ? 328  PRO   B CG  1 
ATOM   7414 C  CD  . PRO   B 2 327 ? -15.358 -8.826   -36.990 1.00 126.30 ? 328  PRO   B CD  1 
ATOM   7415 N  N   . THR   B 2 328 ? -16.073 -7.547   -40.364 1.00 136.01 ? 329  THR   B N   1 
ATOM   7416 C  CA  . THR   B 2 328 ? -16.462 -7.577   -41.806 1.00 135.86 ? 329  THR   B CA  1 
ATOM   7417 C  C   . THR   B 2 328 ? -15.933 -6.337   -42.542 1.00 129.36 ? 329  THR   B C   1 
ATOM   7418 O  O   . THR   B 2 328 ? -14.731 -6.103   -42.707 1.00 122.43 ? 329  THR   B O   1 
ATOM   7419 C  CB  . THR   B 2 328 ? -17.986 -7.688   -41.974 1.00 137.55 ? 329  THR   B CB  1 
ATOM   7420 O  OG1 . THR   B 2 328 ? -18.595 -6.450   -41.606 1.00 144.18 ? 329  THR   B OG1 1 
ATOM   7421 C  CG2 . THR   B 2 328 ? -18.599 -8.798   -41.150 1.00 134.82 ? 329  THR   B CG2 1 
HETATM 7422 N  N1  . A1A79 C 3 .   ? -15.867 -101.764 -3.727  1.00 50.55  ? 701  A1A79 A N1  1 
HETATM 7423 N  N3  . A1A79 C 3 .   ? -13.529 -104.855 -2.589  1.00 52.98  ? 701  A1A79 A N3  1 
HETATM 7424 C  C4  . A1A79 C 3 .   ? -21.773 -100.307 -6.195  1.00 55.80  ? 701  A1A79 A C4  1 
HETATM 7425 C  C5  . A1A79 C 3 .   ? -20.653 -99.489  -6.302  1.00 55.64  ? 701  A1A79 A C5  1 
HETATM 7426 C  C6  . A1A79 C 3 .   ? -20.833 -98.130  -6.525  1.00 57.85  ? 701  A1A79 A C6  1 
HETATM 7427 C  C7  . A1A79 C 3 .   ? -19.269 -100.088 -6.178  1.00 54.29  ? 701  A1A79 A C7  1 
HETATM 7428 C  C8  . A1A79 C 3 .   ? -19.103 -100.793 -4.816  1.00 51.87  ? 701  A1A79 A C8  1 
HETATM 7429 C  C10 . A1A79 C 3 .   ? -17.580 -100.050 -3.074  1.00 51.23  ? 701  A1A79 A C10 1 
HETATM 7430 C  C13 . A1A79 C 3 .   ? -13.905 -102.808 -3.675  1.00 50.33  ? 701  A1A79 A C13 1 
HETATM 7431 C  C15 . A1A79 C 3 .   ? -14.990 -100.996 -4.445  1.00 50.97  ? 701  A1A79 A C15 1 
HETATM 7432 C  C17 . A1A79 C 3 .   ? -13.043 -103.850 -3.306  1.00 51.18  ? 701  A1A79 A C17 1 
HETATM 7433 C  C1  . A1A79 C 3 .   ? -22.111 -97.608  -6.627  1.00 58.54  ? 701  A1A79 A C1  1 
HETATM 7434 C  C2  . A1A79 C 3 .   ? -23.222 -98.421  -6.518  1.00 56.34  ? 701  A1A79 A C2  1 
HETATM 7435 C  C3  . A1A79 C 3 .   ? -23.050 -99.769  -6.292  1.00 55.44  ? 701  A1A79 A C3  1 
HETATM 7436 CL CL1 . A1A79 C 3 .   ? -22.325 -95.915  -6.894  1.00 65.00  ? 701  A1A79 A CL1 1 
HETATM 7437 CL CL2 . A1A79 C 3 .   ? -24.809 -97.723  -6.651  1.00 62.24  ? 701  A1A79 A CL2 1 
HETATM 7438 O  O1  . A1A79 C 3 .   ? -18.225 -99.120  -6.363  1.00 55.16  ? 701  A1A79 A O1  1 
HETATM 7439 C  C9  . A1A79 C 3 .   ? -19.063 -99.902  -3.538  1.00 51.26  ? 701  A1A79 A C9  1 
HETATM 7440 C  C11 . A1A79 C 3 .   ? -17.279 -101.489 -3.534  1.00 49.53  ? 701  A1A79 A C11 1 
HETATM 7441 O  O2  . A1A79 C 3 .   ? -17.859 -101.528 -4.848  1.00 50.58  ? 701  A1A79 A O2  1 
HETATM 7442 O  O3  . A1A79 C 3 .   ? -17.418 -99.904  -1.660  1.00 52.68  ? 701  A1A79 A O3  1 
HETATM 7443 C  C12 . A1A79 C 3 .   ? -15.245 -102.876 -3.254  1.00 51.14  ? 701  A1A79 A C12 1 
HETATM 7444 C  C14 . A1A79 C 3 .   ? -13.781 -101.572 -4.440  1.00 50.33  ? 701  A1A79 A C14 1 
HETATM 7445 N  N2  . A1A79 C 3 .   ? -15.649 -103.918 -2.521  1.00 52.38  ? 701  A1A79 A N2  1 
HETATM 7446 C  C16 . A1A79 C 3 .   ? -14.800 -104.875 -2.207  1.00 53.19  ? 701  A1A79 A C16 1 
HETATM 7447 N  N4  . A1A79 C 3 .   ? -11.727 -103.860 -3.700  1.00 53.72  ? 701  A1A79 A N4  1 
HETATM 7448 C  C18 . A1A79 C 3 .   ? -19.357 -98.402  -3.662  1.00 52.46  ? 701  A1A79 A C18 1 
HETATM 7449 O  O4  . A1A79 C 3 .   ? -20.009 -100.435 -2.619  1.00 46.52  ? 701  A1A79 A O4  1 
HETATM 7450 C  C1  . EDO   D 4 .   ? -20.450 -93.193  -10.478 1.00 67.71  ? 702  EDO   A C1  1 
HETATM 7451 O  O1  . EDO   D 4 .   ? -20.057 -94.551  -10.577 1.00 66.75  ? 702  EDO   A O1  1 
HETATM 7452 C  C2  . EDO   D 4 .   ? -19.358 -92.241  -10.833 1.00 66.17  ? 702  EDO   A C2  1 
HETATM 7453 O  O2  . EDO   D 4 .   ? -19.653 -91.370  -11.919 1.00 67.05  ? 702  EDO   A O2  1 
HETATM 7454 C  C1  . EDO   E 4 .   ? -6.114  -56.307  -30.145 1.00 80.36  ? 703  EDO   A C1  1 
HETATM 7455 O  O1  . EDO   E 4 .   ? -5.592  -55.662  -31.294 1.00 82.36  ? 703  EDO   A O1  1 
HETATM 7456 C  C2  . EDO   E 4 .   ? -6.374  -55.382  -29.004 1.00 78.02  ? 703  EDO   A C2  1 
HETATM 7457 O  O2  . EDO   E 4 .   ? -7.730  -55.298  -28.585 1.00 73.64  ? 703  EDO   A O2  1 
HETATM 7458 C  C1  . EDO   F 4 .   ? -20.864 -99.638  -12.856 0.90 54.60  ? 704  EDO   A C1  1 
HETATM 7459 O  O1  . EDO   F 4 .   ? -20.900 -99.877  -14.256 0.90 53.47  ? 704  EDO   A O1  1 
HETATM 7460 C  C2  . EDO   F 4 .   ? -22.142 -99.056  -12.362 0.90 57.45  ? 704  EDO   A C2  1 
HETATM 7461 O  O2  . EDO   F 4 .   ? -22.124 -98.531  -11.027 0.90 54.98  ? 704  EDO   A O2  1 
HETATM 7462 C  C1  . EDO   G 4 .   ? -31.637 -44.754  -2.980  1.00 73.11  ? 705  EDO   A C1  1 
HETATM 7463 O  O1  . EDO   G 4 .   ? -30.817 -45.911  -2.824  1.00 70.74  ? 705  EDO   A O1  1 
HETATM 7464 C  C2  . EDO   G 4 .   ? -32.698 -44.607  -1.934  1.00 73.87  ? 705  EDO   A C2  1 
HETATM 7465 O  O2  . EDO   G 4 .   ? -32.216 -44.225  -0.644  1.00 70.64  ? 705  EDO   A O2  1 
HETATM 7466 O  O   . HOH   H 5 .   ? -22.461 -52.920  -12.984 1.00 64.77  ? 801  HOH   A O   1 
HETATM 7467 O  O   . HOH   H 5 .   ? -33.348 -39.690  -22.203 1.00 59.50  ? 802  HOH   A O   1 
HETATM 7468 O  O   . HOH   H 5 .   ? -4.004  -41.418  -23.861 1.00 59.38  ? 803  HOH   A O   1 
HETATM 7469 O  O   . HOH   H 5 .   ? -16.244 -101.555 -25.102 1.00 69.14  ? 804  HOH   A O   1 
HETATM 7470 O  O   . HOH   H 5 .   ? -31.263 -35.773  -4.548  1.00 54.05  ? 805  HOH   A O   1 
HETATM 7471 O  O   . HOH   H 5 .   ? -6.311  -90.700  -33.236 1.00 58.40  ? 806  HOH   A O   1 
HETATM 7472 O  O   . HOH   H 5 .   ? -19.182 -63.274  -34.675 1.00 56.28  ? 807  HOH   A O   1 
HETATM 7473 O  O   . HOH   H 5 .   ? 4.454   -77.133  -8.203  1.00 74.81  ? 808  HOH   A O   1 
HETATM 7474 O  O   . HOH   H 5 .   ? -19.216 -95.805  -8.523  1.00 53.53  ? 809  HOH   A O   1 
HETATM 7475 O  O   . HOH   H 5 .   ? -24.882 -43.675  -19.017 1.00 55.79  ? 810  HOH   A O   1 
HETATM 7476 O  O   . HOH   H 5 .   ? -9.836  -78.263  -7.616  1.00 59.00  ? 811  HOH   A O   1 
HETATM 7477 O  O   . HOH   H 5 .   ? -5.558  -80.659  -3.629  1.00 50.73  ? 812  HOH   A O   1 
HETATM 7478 O  O   . HOH   H 5 .   ? -21.888 -81.381  -12.504 1.00 58.67  ? 813  HOH   A O   1 
HETATM 7479 O  O   . HOH   H 5 .   ? -11.345 -88.112  -7.349  1.00 42.53  ? 814  HOH   A O   1 
HETATM 7480 O  O   . HOH   H 5 .   ? -17.808 -61.647  -36.876 1.00 53.68  ? 815  HOH   A O   1 
HETATM 7481 O  O   . HOH   H 5 .   ? -8.664  -108.944 -14.218 1.00 68.25  ? 816  HOH   A O   1 
HETATM 7482 O  O   . HOH   H 5 .   ? -19.755 -97.848  -10.247 1.00 50.39  ? 817  HOH   A O   1 
HETATM 7483 O  O   . HOH   H 5 .   ? -5.665  -53.422  -32.561 1.00 70.66  ? 818  HOH   A O   1 
HETATM 7484 O  O   . HOH   H 5 .   ? -2.084  -100.465 -11.731 1.00 55.30  ? 819  HOH   A O   1 
HETATM 7485 O  O   . HOH   H 5 .   ? -39.188 -50.566  -4.592  1.00 72.86  ? 820  HOH   A O   1 
HETATM 7486 O  O   . HOH   H 5 .   ? -5.404  -63.538  -20.297 1.00 51.67  ? 821  HOH   A O   1 
HETATM 7487 O  O   . HOH   H 5 .   ? -14.718 -63.036  -18.911 1.00 54.43  ? 822  HOH   A O   1 
HETATM 7488 O  O   . HOH   H 5 .   ? -20.925 -108.213 10.204  1.00 56.86  ? 823  HOH   A O   1 
HETATM 7489 O  O   . HOH   H 5 .   ? -12.222 -87.225  -33.587 1.00 50.85  ? 824  HOH   A O   1 
HETATM 7490 O  O   . HOH   H 5 .   ? -13.089 -98.057  -12.302 1.00 50.55  ? 825  HOH   A O   1 
HETATM 7491 O  O   . HOH   H 5 .   ? -17.375 -97.438  -0.820  1.00 50.32  ? 826  HOH   A O   1 
HETATM 7492 O  O   . HOH   H 5 .   ? -34.269 -66.333  -20.230 1.00 77.63  ? 827  HOH   A O   1 
HETATM 7493 O  O   . HOH   H 5 .   ? -17.963 -124.345 -17.551 1.00 72.75  ? 828  HOH   A O   1 
HETATM 7494 O  O   . HOH   H 5 .   ? -25.894 -100.568 -3.784  1.00 58.41  ? 829  HOH   A O   1 
HETATM 7495 O  O   . HOH   H 5 .   ? -28.115 -63.251  -17.263 1.00 68.11  ? 830  HOH   A O   1 
HETATM 7496 O  O   . HOH   H 5 .   ? -29.518 -59.837  -14.770 1.00 56.30  ? 831  HOH   A O   1 
HETATM 7497 O  O   . HOH   H 5 .   ? -24.631 -118.744 -0.985  1.00 69.25  ? 832  HOH   A O   1 
HETATM 7498 O  O   . HOH   H 5 .   ? 0.783   -79.871  -7.811  1.00 56.04  ? 833  HOH   A O   1 
HETATM 7499 O  O   . HOH   H 5 .   ? -24.117 -88.820  -19.260 1.00 54.34  ? 834  HOH   A O   1 
HETATM 7500 O  O   . HOH   H 5 .   ? -13.287 -47.509  -10.225 1.00 54.53  ? 835  HOH   A O   1 
HETATM 7501 O  O   . HOH   H 5 .   ? -19.529 -66.164  -46.583 1.00 69.10  ? 836  HOH   A O   1 
HETATM 7502 O  O   . HOH   H 5 .   ? -21.669 -88.586  -12.341 1.00 59.72  ? 837  HOH   A O   1 
HETATM 7503 O  O   . HOH   H 5 .   ? -12.628 -45.408  -30.960 1.00 52.31  ? 838  HOH   A O   1 
HETATM 7504 O  O   . HOH   H 5 .   ? -0.371  -71.884  2.498   1.00 49.10  ? 839  HOH   A O   1 
HETATM 7505 O  O   . HOH   H 5 .   ? -15.747 -50.633  -28.220 1.00 65.16  ? 840  HOH   A O   1 
HETATM 7506 O  O   . HOH   H 5 .   ? -13.322 -39.895  -13.324 1.00 55.78  ? 841  HOH   A O   1 
HETATM 7507 O  O   . HOH   H 5 .   ? -19.137 -49.451  -4.515  1.00 67.43  ? 842  HOH   A O   1 
HETATM 7508 O  O   . HOH   H 5 .   ? -1.649  -75.727  -22.463 1.00 52.56  ? 843  HOH   A O   1 
HETATM 7509 O  O   . HOH   H 5 .   ? -15.057 -71.819  -36.962 1.00 63.78  ? 844  HOH   A O   1 
HETATM 7510 O  O   . HOH   H 5 .   ? -3.548  -81.392  -5.310  1.00 49.79  ? 845  HOH   A O   1 
HETATM 7511 O  O   . HOH   H 5 .   ? 2.585   -84.345  -31.573 1.00 52.41  ? 846  HOH   A O   1 
HETATM 7512 O  O   . HOH   H 5 .   ? -21.604 -55.840  -6.987  1.00 73.34  ? 847  HOH   A O   1 
HETATM 7513 O  O   . HOH   H 5 .   ? -25.718 -59.389  -11.736 1.00 60.20  ? 848  HOH   A O   1 
HETATM 7514 O  O   . HOH   H 5 .   ? -15.884 -48.872  -40.535 1.00 65.39  ? 849  HOH   A O   1 
HETATM 7515 O  O   . HOH   H 5 .   ? -18.900 -46.001  -6.398  1.00 59.34  ? 850  HOH   A O   1 
HETATM 7516 O  O   . HOH   H 5 .   ? -20.341 -90.540  -0.869  1.00 44.40  ? 851  HOH   A O   1 
HETATM 7517 O  O   . HOH   H 5 .   ? -26.186 -48.521  -3.317  1.00 66.67  ? 852  HOH   A O   1 
HETATM 7518 O  O   . HOH   H 5 .   ? -22.894 -70.631  -27.436 1.00 63.09  ? 853  HOH   A O   1 
HETATM 7519 O  O   . HOH   H 5 .   ? -14.069 -79.472  -35.922 1.00 63.81  ? 854  HOH   A O   1 
HETATM 7520 O  O   . HOH   H 5 .   ? -15.822 -98.739  -7.547  1.00 51.46  ? 855  HOH   A O   1 
HETATM 7521 O  O   . HOH   H 5 .   ? -21.362 -53.243  -30.090 1.00 61.08  ? 856  HOH   A O   1 
HETATM 7522 O  O   . HOH   H 5 .   ? -21.215 -50.320  -51.096 1.00 56.61  ? 857  HOH   A O   1 
HETATM 7523 O  O   . HOH   H 5 .   ? -4.697  -74.557  -6.017  1.00 50.62  ? 858  HOH   A O   1 
HETATM 7524 O  O   . HOH   H 5 .   ? 1.090   -93.601  -27.778 1.00 64.99  ? 859  HOH   A O   1 
HETATM 7525 O  O   . HOH   H 5 .   ? -4.134  -81.335  -39.950 1.00 62.28  ? 860  HOH   A O   1 
HETATM 7526 O  O   . HOH   H 5 .   ? 0.776   -77.799  -10.929 1.00 61.49  ? 861  HOH   A O   1 
HETATM 7527 O  O   . HOH   H 5 .   ? -5.840  -99.826  -23.510 1.00 60.08  ? 862  HOH   A O   1 
HETATM 7528 O  O   . HOH   H 5 .   ? 0.833   -35.168  -24.962 1.00 62.11  ? 863  HOH   A O   1 
HETATM 7529 O  O   . HOH   H 5 .   ? -38.126 -110.284 -16.534 1.00 74.88  ? 864  HOH   A O   1 
HETATM 7530 O  O   . HOH   H 5 .   ? -11.120 -102.037 1.191   1.00 69.49  ? 865  HOH   A O   1 
HETATM 7531 O  O   . HOH   H 5 .   ? -2.881  -39.832  -29.575 1.00 70.35  ? 866  HOH   A O   1 
HETATM 7532 O  O   . HOH   H 5 .   ? -5.397  -63.078  -28.742 1.00 67.62  ? 867  HOH   A O   1 
HETATM 7533 O  O   . HOH   H 5 .   ? -18.007 -64.009  -17.223 1.00 57.51  ? 868  HOH   A O   1 
HETATM 7534 O  O   . HOH   H 5 .   ? -12.644 -72.194  -44.985 1.00 70.66  ? 869  HOH   A O   1 
HETATM 7535 O  O   . HOH   H 5 .   ? -11.337 -55.773  -28.445 1.00 56.00  ? 870  HOH   A O   1 
HETATM 7536 O  O   . HOH   H 5 .   ? -9.676  -94.896  -4.765  1.00 44.84  ? 871  HOH   A O   1 
HETATM 7537 O  O   . HOH   H 5 .   ? -0.539  -100.596 -9.001  1.00 57.24  ? 872  HOH   A O   1 
HETATM 7538 O  O   . HOH   H 5 .   ? -12.455 -48.715  -27.361 1.00 56.04  ? 873  HOH   A O   1 
HETATM 7539 O  O   . HOH   H 5 .   ? -4.718  -103.611 -6.025  1.00 63.39  ? 874  HOH   A O   1 
HETATM 7540 O  O   . HOH   H 5 .   ? 5.287   -81.141  -16.626 1.00 58.12  ? 875  HOH   A O   1 
HETATM 7541 O  O   . HOH   H 5 .   ? -18.512 -74.309  -36.813 1.00 69.96  ? 876  HOH   A O   1 
HETATM 7542 O  O   . HOH   H 5 .   ? 5.581   -80.247  -8.553  1.00 66.49  ? 877  HOH   A O   1 
HETATM 7543 O  O   . HOH   H 5 .   ? -25.477 -50.382  -24.504 1.00 49.67  ? 878  HOH   A O   1 
HETATM 7544 O  O   . HOH   H 5 .   ? -5.711  -112.583 -8.368  1.00 68.09  ? 879  HOH   A O   1 
HETATM 7545 O  O   . HOH   H 5 .   ? -18.434 -52.512  -9.789  1.00 67.60  ? 880  HOH   A O   1 
HETATM 7546 O  O   . HOH   H 5 .   ? -15.387 -90.687  -3.262  1.00 58.42  ? 881  HOH   A O   1 
HETATM 7547 O  O   . HOH   H 5 .   ? -6.259  -70.357  -11.335 1.00 52.88  ? 882  HOH   A O   1 
HETATM 7548 O  O   . HOH   H 5 .   ? -6.779  -89.550  -36.179 1.00 69.45  ? 883  HOH   A O   1 
HETATM 7549 O  O   . HOH   H 5 .   ? -20.696 -104.243 8.879   1.00 58.82  ? 884  HOH   A O   1 
HETATM 7550 O  O   . HOH   H 5 .   ? -14.341 -88.007  -4.450  1.00 62.05  ? 885  HOH   A O   1 
HETATM 7551 O  O   . HOH   H 5 .   ? 0.541   -89.508  -37.469 1.00 63.93  ? 886  HOH   A O   1 
HETATM 7552 O  O   . HOH   H 5 .   ? 4.798   -98.674  -12.935 1.00 57.65  ? 887  HOH   A O   1 
HETATM 7553 O  O   . HOH   H 5 .   ? -16.520 -103.199 -12.676 1.00 55.46  ? 888  HOH   A O   1 
HETATM 7554 O  O   . HOH   H 5 .   ? -13.878 -70.309  -47.389 1.00 72.01  ? 889  HOH   A O   1 
HETATM 7555 O  O   . HOH   H 5 .   ? -32.122 -54.852  -2.748  1.00 63.08  ? 890  HOH   A O   1 
HETATM 7556 O  O   . HOH   H 5 .   ? 2.429   -95.487  -17.649 1.00 53.42  ? 891  HOH   A O   1 
HETATM 7557 O  O   . HOH   H 5 .   ? -35.434 -106.697 -16.251 1.00 65.70  ? 892  HOH   A O   1 
HETATM 7558 O  O   . HOH   H 5 .   ? -15.522 -52.754  -9.177  1.00 59.41  ? 893  HOH   A O   1 
HETATM 7559 O  O   . HOH   H 5 .   ? -1.822  -106.295 -19.142 1.00 64.53  ? 894  HOH   A O   1 
HETATM 7560 O  O   . HOH   H 5 .   ? -7.576  -43.878  -17.306 1.00 64.32  ? 895  HOH   A O   1 
HETATM 7561 O  O   . HOH   H 5 .   ? -15.529 -72.926  -30.535 1.00 67.72  ? 896  HOH   A O   1 
HETATM 7562 O  O   . HOH   H 5 .   ? -2.240  -70.996  -28.358 1.00 55.44  ? 897  HOH   A O   1 
HETATM 7563 O  O   . HOH   H 5 .   ? -4.148  -104.417 -18.532 1.00 49.45  ? 898  HOH   A O   1 
HETATM 7564 O  O   . HOH   H 5 .   ? -48.015 -51.975  -37.740 1.00 77.88  ? 899  HOH   A O   1 
HETATM 7565 O  O   . HOH   H 5 .   ? -26.614 -79.822  -20.328 1.00 67.33  ? 900  HOH   A O   1 
HETATM 7566 O  O   . HOH   H 5 .   ? -27.682 -74.811  -11.710 1.00 69.27  ? 901  HOH   A O   1 
HETATM 7567 O  O   . HOH   H 5 .   ? -14.058 -65.094  -20.811 1.00 55.09  ? 902  HOH   A O   1 
HETATM 7568 O  O   . HOH   H 5 .   ? -23.476 -26.342  -9.088  1.00 73.20  ? 903  HOH   A O   1 
HETATM 7569 O  O   . HOH   H 5 .   ? -15.772 -50.728  -36.481 1.00 57.15  ? 904  HOH   A O   1 
HETATM 7570 O  O   . HOH   H 5 .   ? -29.183 -42.198  -13.478 1.00 65.36  ? 905  HOH   A O   1 
HETATM 7571 O  O   . HOH   H 5 .   ? -40.516 -49.252  -23.841 1.00 58.64  ? 906  HOH   A O   1 
HETATM 7572 O  O   . HOH   H 5 .   ? -12.767 -46.232  -28.126 1.00 61.70  ? 907  HOH   A O   1 
HETATM 7573 O  O   . HOH   H 5 .   ? -20.697 -79.674  -28.940 1.00 64.60  ? 908  HOH   A O   1 
HETATM 7574 O  O   . HOH   H 5 .   ? -12.199 -52.103  -36.132 1.00 56.19  ? 909  HOH   A O   1 
HETATM 7575 O  O   . HOH   H 5 .   ? -15.818 -91.524  -10.352 1.00 51.69  ? 910  HOH   A O   1 
HETATM 7576 O  O   . HOH   H 5 .   ? -13.517 -99.866  -7.471  1.00 50.68  ? 911  HOH   A O   1 
HETATM 7577 O  O   . HOH   H 5 .   ? -11.284 -56.613  -37.231 1.00 57.11  ? 912  HOH   A O   1 
HETATM 7578 O  O   . HOH   H 5 .   ? -25.917 -98.407  -26.472 1.00 65.85  ? 913  HOH   A O   1 
HETATM 7579 O  O   . HOH   H 5 .   ? -26.833 -82.377  -20.576 1.00 67.19  ? 914  HOH   A O   1 
HETATM 7580 O  O   . HOH   H 5 .   ? -6.348  -80.894  -42.837 1.00 63.52  ? 915  HOH   A O   1 
HETATM 7581 O  O   . HOH   H 5 .   ? -15.145 -67.249  -19.462 1.00 56.90  ? 916  HOH   A O   1 
HETATM 7582 O  O   . HOH   H 5 .   ? -18.178 -75.580  -9.810  1.00 64.50  ? 917  HOH   A O   1 
HETATM 7583 O  O   . HOH   H 5 .   ? -13.745 -124.484 -6.202  1.00 69.53  ? 918  HOH   A O   1 
HETATM 7584 O  O   . HOH   H 5 .   ? -27.472 -56.384  -7.593  1.00 59.88  ? 919  HOH   A O   1 
HETATM 7585 O  O   . HOH   H 5 .   ? -11.352 -98.258  -19.549 1.00 54.14  ? 920  HOH   A O   1 
HETATM 7586 O  O   . HOH   H 5 .   ? -11.658 -98.418  2.593   1.00 61.88  ? 921  HOH   A O   1 
HETATM 7587 O  O   . HOH   H 5 .   ? -25.296 -59.169  -35.827 1.00 68.68  ? 922  HOH   A O   1 
HETATM 7588 O  O   . HOH   H 5 .   ? 0.034   -102.331 -13.312 1.00 54.71  ? 923  HOH   A O   1 
HETATM 7589 O  O   . HOH   H 5 .   ? -11.842 -92.396  3.283   1.00 64.05  ? 924  HOH   A O   1 
HETATM 7590 O  O   . HOH   H 5 .   ? -21.627 -84.573  -23.460 1.00 65.57  ? 925  HOH   A O   1 
HETATM 7591 O  O   . HOH   H 5 .   ? -27.565 -94.097  -28.367 1.00 68.05  ? 926  HOH   A O   1 
HETATM 7592 O  O   . HOH   H 5 .   ? -16.689 -66.824  -17.418 1.00 58.05  ? 927  HOH   A O   1 
HETATM 7593 O  O   . HOH   H 5 .   ? -11.872 -95.530  -6.391  1.00 51.91  ? 928  HOH   A O   1 
HETATM 7594 O  O   . HOH   H 5 .   ? 4.098   -72.736  -14.255 1.00 71.44  ? 929  HOH   A O   1 
HETATM 7595 O  O   . HOH   H 5 .   ? -14.342 -93.157  3.961   1.00 61.26  ? 930  HOH   A O   1 
HETATM 7596 O  O   . HOH   H 5 .   ? -23.825 -125.182 -22.690 1.00 60.77  ? 931  HOH   A O   1 
HETATM 7597 O  O   . HOH   H 5 .   ? -12.961 -40.826  -31.447 1.00 58.92  ? 932  HOH   A O   1 
HETATM 7598 O  O   . HOH   H 5 .   ? -1.001  -98.574  -23.762 1.00 59.13  ? 933  HOH   A O   1 
HETATM 7599 O  O   . HOH   H 5 .   ? -14.393 -115.138 -19.825 1.00 62.11  ? 934  HOH   A O   1 
HETATM 7600 O  O   . HOH   H 5 .   ? -10.325 -88.865  0.568   1.00 61.38  ? 935  HOH   A O   1 
HETATM 7601 O  O   . HOH   H 5 .   ? -8.779  -79.679  -43.032 1.00 59.45  ? 936  HOH   A O   1 
HETATM 7602 O  O   . HOH   H 5 .   ? -27.134 -103.285 -25.270 1.00 54.50  ? 937  HOH   A O   1 
HETATM 7603 O  O   . HOH   H 5 .   ? -18.147 -89.474  -9.881  1.00 46.23  ? 938  HOH   A O   1 
HETATM 7604 O  O   . HOH   H 5 .   ? -16.736 -90.426  -12.431 1.00 49.09  ? 939  HOH   A O   1 
HETATM 7605 O  O   . HOH   H 5 .   ? -17.279 -82.552  -33.297 1.00 62.11  ? 940  HOH   A O   1 
HETATM 7606 O  O   . HOH   H 5 .   ? -10.001 -50.443  -34.057 1.00 57.26  ? 941  HOH   A O   1 
HETATM 7607 O  O   . HOH   H 5 .   ? -15.626 -71.440  -25.574 1.00 63.47  ? 942  HOH   A O   1 
HETATM 7608 O  O   . HOH   H 5 .   ? -23.771 -59.930  -43.795 1.00 67.20  ? 943  HOH   A O   1 
HETATM 7609 O  O   . HOH   H 5 .   ? -18.221 -111.071 6.876   1.00 60.01  ? 944  HOH   A O   1 
HETATM 7610 O  O   . HOH   H 5 .   ? -4.876  -67.502  -19.488 1.00 53.43  ? 945  HOH   A O   1 
HETATM 7611 O  O   . HOH   H 5 .   ? -12.968 -100.930 4.573   1.00 59.29  ? 946  HOH   A O   1 
HETATM 7612 O  O   . HOH   H 5 .   ? -48.852 -54.884  -21.917 1.00 72.00  ? 947  HOH   A O   1 
HETATM 7613 O  O   . HOH   H 5 .   ? -41.082 -49.592  -9.557  1.00 71.67  ? 948  HOH   A O   1 
HETATM 7614 O  O   . HOH   H 5 .   ? -5.515  -86.441  -5.087  1.00 50.71  ? 949  HOH   A O   1 
HETATM 7615 O  O   . HOH   H 5 .   ? -16.856 -47.971  -34.072 1.00 70.69  ? 950  HOH   A O   1 
HETATM 7616 O  O   . HOH   H 5 .   ? -19.330 -86.018  -6.847  1.00 62.50  ? 951  HOH   A O   1 
HETATM 7617 O  O   . HOH   H 5 .   ? -15.298 -32.377  -14.331 1.00 65.50  ? 952  HOH   A O   1 
HETATM 7618 O  O   . HOH   H 5 .   ? -7.768  -99.557  0.478   1.00 69.68  ? 953  HOH   A O   1 
HETATM 7619 O  O   . HOH   H 5 .   ? -12.222 -63.479  -11.824 1.00 66.44  ? 954  HOH   A O   1 
HETATM 7620 O  O   . HOH   H 5 .   ? -35.427 -104.867 1.954   1.00 63.19  ? 955  HOH   A O   1 
HETATM 7621 O  O   . HOH   H 5 .   ? -1.114  -95.076  -29.143 1.00 55.34  ? 956  HOH   A O   1 
HETATM 7622 O  O   . HOH   H 5 .   ? -21.843 -67.834  -18.107 1.00 62.28  ? 957  HOH   A O   1 
HETATM 7623 O  O   . HOH   H 5 .   ? -24.123 -85.024  -7.159  1.00 63.02  ? 958  HOH   A O   1 
HETATM 7624 O  O   . HOH   H 5 .   ? -17.708 -33.931  -14.676 1.00 61.65  ? 959  HOH   A O   1 
HETATM 7625 O  O   . HOH   H 5 .   ? -26.764 -72.286  -18.341 1.00 73.27  ? 960  HOH   A O   1 
HETATM 7626 O  O   . HOH   H 5 .   ? -25.707 -46.287  -26.598 1.00 68.65  ? 961  HOH   A O   1 
HETATM 7627 O  O   . HOH   H 5 .   ? -9.447  -40.843  -15.282 1.00 62.29  ? 962  HOH   A O   1 
HETATM 7628 O  O   . HOH   H 5 .   ? -0.014  -76.227  -20.461 1.00 55.60  ? 963  HOH   A O   1 
HETATM 7629 O  O   . HOH   H 5 .   ? -2.232  -85.923  -4.831  1.00 64.00  ? 964  HOH   A O   1 
HETATM 7630 O  O   . HOH   H 5 .   ? -31.695 -58.568  -14.147 1.00 52.72  ? 965  HOH   A O   1 
HETATM 7631 O  O   . HOH   H 5 .   ? 1.562   -37.085  -23.380 1.00 52.66  ? 966  HOH   A O   1 
HETATM 7632 O  O   . HOH   H 5 .   ? -34.330 -59.004  -13.373 1.00 74.43  ? 967  HOH   A O   1 
HETATM 7633 O  O   . HOH   H 5 .   ? -24.830 -55.794  -7.591  1.00 62.19  ? 968  HOH   A O   1 
HETATM 7634 O  O   . HOH   H 5 .   ? -17.125 -52.533  -38.021 1.00 67.34  ? 969  HOH   A O   1 
HETATM 7635 O  O   . HOH   H 5 .   ? -33.723 -71.778  -13.680 1.00 76.23  ? 970  HOH   A O   1 
HETATM 7636 O  O   . HOH   H 5 .   ? -38.301 -44.512  -3.473  1.00 68.39  ? 971  HOH   A O   1 
HETATM 7637 O  O   . HOH   H 5 .   ? 4.275   -76.008  -11.498 1.00 64.61  ? 972  HOH   A O   1 
HETATM 7638 O  O   . HOH   H 5 .   ? -14.137 -80.138  -7.114  1.00 57.34  ? 973  HOH   A O   1 
HETATM 7639 O  O   . HOH   H 5 .   ? -9.686  -119.854 -5.302  1.00 74.62  ? 974  HOH   A O   1 
HETATM 7640 O  O   . HOH   H 5 .   ? -4.824  -119.055 -7.221  1.00 71.13  ? 975  HOH   A O   1 
HETATM 7641 O  O   . HOH   H 5 .   ? -4.649  -45.223  -13.474 1.00 54.98  ? 976  HOH   A O   1 
HETATM 7642 O  O   . HOH   H 5 .   ? -18.875 -109.496 9.147   1.00 61.75  ? 977  HOH   A O   1 
HETATM 7643 O  O   . HOH   H 5 .   ? -31.209 -93.753  -25.647 1.00 61.02  ? 978  HOH   A O   1 
HETATM 7644 O  O   . HOH   H 5 .   ? -16.868 -60.716  -4.226  1.00 74.09  ? 979  HOH   A O   1 
HETATM 7645 O  O   . HOH   H 5 .   ? -4.226  -35.590  -31.033 1.00 62.39  ? 980  HOH   A O   1 
HETATM 7646 O  O   . HOH   H 5 .   ? -33.671 -67.089  -17.834 1.00 77.27  ? 981  HOH   A O   1 
HETATM 7647 O  O   . HOH   H 5 .   ? -6.128  -119.101 -11.060 1.00 68.57  ? 982  HOH   A O   1 
HETATM 7648 O  O   . HOH   H 5 .   ? -13.899 -44.752  -6.454  1.00 59.25  ? 983  HOH   A O   1 
HETATM 7649 O  O   . HOH   H 5 .   ? -23.246 -53.644  -33.719 1.00 61.33  ? 984  HOH   A O   1 
HETATM 7650 O  O   . HOH   H 5 .   ? 2.759   -88.545  -33.618 1.00 55.16  ? 985  HOH   A O   1 
HETATM 7651 O  O   . HOH   H 5 .   ? -9.741  -59.273  -34.037 1.00 55.00  ? 986  HOH   A O   1 
HETATM 7652 O  O   . HOH   H 5 .   ? -31.631 -128.733 -25.090 1.00 66.24  ? 987  HOH   A O   1 
HETATM 7653 O  O   . HOH   H 5 .   ? -24.450 -70.900  -19.484 1.00 55.76  ? 988  HOH   A O   1 
HETATM 7654 O  O   . HOH   H 5 .   ? -6.776  -57.943  -3.155  1.00 75.00  ? 989  HOH   A O   1 
HETATM 7655 O  O   . HOH   H 5 .   ? -47.446 -67.235  -34.035 1.00 69.50  ? 990  HOH   A O   1 
HETATM 7656 O  O   . HOH   H 5 .   ? -14.794 -114.432 5.356   1.00 66.09  ? 991  HOH   A O   1 
HETATM 7657 O  O   . HOH   H 5 .   ? -32.575 -86.033  0.575   1.00 54.54  ? 992  HOH   A O   1 
HETATM 7658 O  O   . HOH   H 5 .   ? -25.460 -86.738  -9.314  1.00 67.40  ? 993  HOH   A O   1 
HETATM 7659 O  O   . HOH   H 5 .   ? -22.713 -47.352  -26.937 1.00 62.59  ? 994  HOH   A O   1 
HETATM 7660 O  O   . HOH   H 5 .   ? -1.113  -90.597  -39.336 1.00 72.57  ? 995  HOH   A O   1 
HETATM 7661 O  O   . HOH   H 5 .   ? -12.545 -54.562  -38.213 1.00 59.36  ? 996  HOH   A O   1 
HETATM 7662 O  O   . HOH   H 5 .   ? -5.974  -56.025  -7.036  1.00 67.19  ? 997  HOH   A O   1 
HETATM 7663 O  O   . HOH   H 5 .   ? -24.418 -63.401  -13.948 1.00 75.90  ? 998  HOH   A O   1 
HETATM 7664 O  O   . HOH   H 5 .   ? -17.425 -90.145  -1.286  1.00 52.26  ? 999  HOH   A O   1 
HETATM 7665 O  O   . HOH   H 5 .   ? -12.914 -59.378  -9.361  1.00 67.18  ? 1000 HOH   A O   1 
HETATM 7666 O  O   . HOH   H 5 .   ? -20.052 -88.037  -8.647  1.00 55.44  ? 1001 HOH   A O   1 
HETATM 7667 O  O   . HOH   H 5 .   ? -6.442  -99.363  -27.916 1.00 64.54  ? 1002 HOH   A O   1 
HETATM 7668 O  O   . HOH   H 5 .   ? 0.000   -93.789  0.000   0.50 60.67  ? 1003 HOH   A O   1 
HETATM 7669 O  O   . HOH   H 5 .   ? -30.229 -59.819  -5.844  1.00 71.15  ? 1004 HOH   A O   1 
HETATM 7670 O  O   . HOH   H 5 .   ? -7.543  -116.699 -15.571 1.00 57.36  ? 1005 HOH   A O   1 
HETATM 7671 O  O   . HOH   H 5 .   ? -2.311  -88.336  -40.390 1.00 64.44  ? 1006 HOH   A O   1 
HETATM 7672 O  O   . HOH   H 5 .   ? -24.083 -81.146  -25.632 1.00 74.25  ? 1007 HOH   A O   1 
HETATM 7673 O  O   . HOH   H 5 .   ? -15.456 -74.613  -48.101 1.00 56.58  ? 1008 HOH   A O   1 
HETATM 7674 O  O   . HOH   H 5 .   ? -37.581 -66.435  -9.924  1.00 73.17  ? 1009 HOH   A O   1 
HETATM 7675 O  O   . HOH   H 5 .   ? -24.791 -63.057  -47.195 1.00 72.31  ? 1010 HOH   A O   1 
HETATM 7676 O  O   . HOH   H 5 .   ? -43.210 -42.991  -2.116  1.00 70.12  ? 1011 HOH   A O   1 
HETATM 7677 O  O   . HOH   I 5 .   ? -29.210 -30.144  -26.043 1.00 74.29  ? 401  HOH   B O   1 
HETATM 7678 O  O   . HOH   I 5 .   ? -30.859 -30.050  -51.113 1.00 56.97  ? 402  HOH   B O   1 
HETATM 7679 O  O   . HOH   I 5 .   ? -4.205  -40.622  -37.429 1.00 65.87  ? 403  HOH   B O   1 
HETATM 7680 O  O   . HOH   I 5 .   ? -40.533 -25.297  -52.916 1.00 69.75  ? 404  HOH   B O   1 
HETATM 7681 O  O   . HOH   I 5 .   ? -46.520 -20.242  -26.934 1.00 60.14  ? 405  HOH   B O   1 
HETATM 7682 O  O   . HOH   I 5 .   ? -33.769 -43.487  -28.396 1.00 64.95  ? 406  HOH   B O   1 
HETATM 7683 O  O   . HOH   I 5 .   ? -14.937 -35.238  -54.892 1.00 70.34  ? 407  HOH   B O   1 
HETATM 7684 O  O   . HOH   I 5 .   ? -23.770 -22.269  -43.868 1.00 62.61  ? 408  HOH   B O   1 
HETATM 7685 O  O   . HOH   I 5 .   ? -41.749 -36.691  -21.834 1.00 56.26  ? 409  HOH   B O   1 
HETATM 7686 O  O   . HOH   I 5 .   ? -24.296 -27.061  -42.535 1.00 54.51  ? 410  HOH   B O   1 
HETATM 7687 O  O   . HOH   I 5 .   ? -30.393 -29.850  -17.709 1.00 65.91  ? 411  HOH   B O   1 
HETATM 7688 O  O   . HOH   I 5 .   ? -8.598  -36.854  -48.091 1.00 78.81  ? 412  HOH   B O   1 
HETATM 7689 O  O   . HOH   I 5 .   ? -14.119 -40.007  -46.253 1.00 59.65  ? 413  HOH   B O   1 
HETATM 7690 O  O   . HOH   I 5 .   ? -19.011 -38.890  -30.160 1.00 50.23  ? 414  HOH   B O   1 
HETATM 7691 O  O   . HOH   I 5 .   ? -36.648 -38.962  -13.737 1.00 59.90  ? 415  HOH   B O   1 
HETATM 7692 O  O   . HOH   I 5 .   ? -25.852 -44.983  -29.129 1.00 56.34  ? 416  HOH   B O   1 
HETATM 7693 O  O   . HOH   I 5 .   ? -26.395 -32.294  -60.628 1.00 73.10  ? 417  HOH   B O   1 
HETATM 7694 O  O   . HOH   I 5 .   ? -38.030 -34.014  -28.775 1.00 60.80  ? 418  HOH   B O   1 
HETATM 7695 O  O   . HOH   I 5 .   ? -42.897 -43.840  -43.227 1.00 74.83  ? 419  HOH   B O   1 
HETATM 7696 O  O   . HOH   I 5 .   ? -10.657 -38.659  -42.338 1.00 66.58  ? 420  HOH   B O   1 
HETATM 7697 O  O   . HOH   I 5 .   ? -13.663 -18.072  -21.879 1.00 72.77  ? 421  HOH   B O   1 
HETATM 7698 O  O   . HOH   I 5 .   ? -21.725 -39.937  -29.446 1.00 54.46  ? 422  HOH   B O   1 
HETATM 7699 O  O   . HOH   I 5 .   ? -45.705 -27.344  -23.743 1.00 72.26  ? 423  HOH   B O   1 
HETATM 7700 O  O   . HOH   I 5 .   ? -3.791  -25.185  -46.032 1.00 68.77  ? 424  HOH   B O   1 
HETATM 7701 O  O   . HOH   I 5 .   ? -26.804 -18.303  -40.604 1.00 64.82  ? 425  HOH   B O   1 
HETATM 7702 O  O   . HOH   I 5 .   ? -48.350 -41.329  -35.389 1.00 75.06  ? 426  HOH   B O   1 
HETATM 7703 O  O   . HOH   I 5 .   ? -21.466 -39.166  -34.003 1.00 55.04  ? 427  HOH   B O   1 
HETATM 7704 O  O   B HOH   I 5 .   ? -48.327 -24.994  -24.524 1.00 75.07  ? 428  HOH   B O   1 
HETATM 7705 O  O   . HOH   I 5 .   ? -31.419 -45.050  -59.602 1.00 69.15  ? 429  HOH   B O   1 
HETATM 7706 O  O   . HOH   I 5 .   ? -47.343 -23.222  -18.744 1.00 78.33  ? 430  HOH   B O   1 
HETATM 7707 O  O   . HOH   I 5 .   ? -28.989 -30.938  -60.854 1.00 61.31  ? 431  HOH   B O   1 
HETATM 7708 O  O   . HOH   I 5 .   ? -43.984 -35.373  -29.000 1.00 67.37  ? 432  HOH   B O   1 
HETATM 7709 O  O   . HOH   I 5 .   ? -35.384 -45.449  -29.795 1.00 67.43  ? 433  HOH   B O   1 
HETATM 7710 O  O   . HOH   I 5 .   ? -23.395 -8.210   -48.824 1.00 67.64  ? 434  HOH   B O   1 
HETATM 7711 O  O   . HOH   I 5 .   ? -5.746  -30.213  -31.087 1.00 58.95  ? 435  HOH   B O   1 
HETATM 7712 O  O   . HOH   I 5 .   ? -26.917 -27.537  -34.180 1.00 65.66  ? 436  HOH   B O   1 
HETATM 7713 O  O   . HOH   I 5 .   ? -17.174 -48.839  -37.803 1.00 56.49  ? 437  HOH   B O   1 
HETATM 7714 O  O   . HOH   I 5 .   ? -26.241 -28.739  -37.107 1.00 73.30  ? 438  HOH   B O   1 
HETATM 7715 O  O   . HOH   I 5 .   ? -4.153  -40.132  -35.152 1.00 68.78  ? 439  HOH   B O   1 
HETATM 7716 O  O   . HOH   I 5 .   ? -57.926 -22.492  -41.873 1.00 70.03  ? 440  HOH   B O   1 
HETATM 7717 O  O   . HOH   I 5 .   ? -15.791 -39.950  -30.501 1.00 53.76  ? 441  HOH   B O   1 
HETATM 7718 O  O   . HOH   I 5 .   ? -13.382 -46.429  -44.421 1.00 58.33  ? 442  HOH   B O   1 
HETATM 7719 O  O   . HOH   I 5 .   ? -46.779 -42.522  -33.124 1.00 68.52  ? 443  HOH   B O   1 
HETATM 7720 O  O   . HOH   I 5 .   ? -26.429 -49.002  -29.565 1.00 61.00  ? 444  HOH   B O   1 
HETATM 7721 O  O   . HOH   I 5 .   ? -25.756 -19.674  -57.251 1.00 71.40  ? 445  HOH   B O   1 
HETATM 7722 O  O   . HOH   I 5 .   ? -15.953 -7.576   -46.115 1.00 64.23  ? 446  HOH   B O   1 
HETATM 7723 O  O   . HOH   I 5 .   ? -13.210 -48.338  -48.909 1.00 69.76  ? 447  HOH   B O   1 
HETATM 7724 O  O   . HOH   I 5 .   ? -12.701 -37.425  -43.506 1.00 61.84  ? 448  HOH   B O   1 
HETATM 7725 O  O   . HOH   I 5 .   ? -24.108 -27.362  -38.517 1.00 69.19  ? 449  HOH   B O   1 
HETATM 7726 O  O   . HOH   I 5 .   ? -46.088 -40.276  -25.819 1.00 68.92  ? 450  HOH   B O   1 
HETATM 7727 O  O   . HOH   I 5 .   ? -53.280 -37.345  -39.853 1.00 64.11  ? 451  HOH   B O   1 
HETATM 7728 O  O   . HOH   I 5 .   ? -45.723 -27.555  -20.691 1.00 75.10  ? 452  HOH   B O   1 
HETATM 7729 O  O   . HOH   I 5 .   ? -42.605 -5.983   -21.524 1.00 64.80  ? 453  HOH   B O   1 
HETATM 7730 O  O   . HOH   I 5 .   ? -18.407 -21.550  -59.293 1.00 64.37  ? 454  HOH   B O   1 
HETATM 7731 O  O   . HOH   I 5 .   ? 0.465   -38.958  -33.081 1.00 59.94  ? 455  HOH   B O   1 
# 
