data_9DNM
# 
_entry.id   9DNM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DNM         pdb_00009dnm 10.2210/pdb9dnm/pdb 
WWPDB D_1000288510 ?            ?                   
EMDB  EMD-47042    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DNM 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  'Structure of rat beta-arrestin 1 in the app state'              9DNG      unspecified            
EMDB 'Map of rat beta-arrestin 1 in the app state'                    EMD-47040 'other EM volume'      
EMDB 'Structure of rat beta-arrestin 1 bound to allosteric inhibitor' EMD-47042 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              lefko001@receptor-biol.duke.edu 
_pdbx_contact_author.name_first         Robert 
_pdbx_contact_author.name_last          Lefkowitz 
_pdbx_contact_author.name_mi            J 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1472-7545 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Pakharukova, N.' 1 0000-0002-8363-6105 
'Kahsai, A.W.'    2 0000-0002-1643-0879 
'Masoudi, A.'     3 0000-0001-5691-9495 
'Lefkowitz, R.J.' 4 0000-0003-1472-7545 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Small Molecule Modulators of beta-arrestins.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.12.27.630464 
_citation.pdbx_database_id_PubMed   39763753 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kahsai, A.W.'    1  0000-0001-9272-4484 
primary 'Pakharukova, N.' 2  0000-0002-8363-6105 
primary 'Kwon, H.Y.'      3  ?                   
primary 'Shah, K.S.'      4  0000-0001-9906-3025 
primary 'Liang-Lin, J.G.' 5  0000-0003-4277-6694 
primary 'Del Real, C.T.'  6  0009-0002-7466-4435 
primary 'Shim, P.J.'      7  0000-0002-6610-8378 
primary 'Lee, M.A.'       8  0000-0001-8772-3567 
primary 'Ngo, V.A.'       9  0000-0001-8350-1203 
primary 'Shreiber, B.N.'  10 ?                   
primary 'Liu, S.'         11 ?                   
primary 'Schwalb, A.M.'   12 0000-0002-1905-8988 
primary 'Espinoza, E.F.'  13 0000-0002-7889-7458 
primary 'Thomas, B.N.'    14 0000-0001-8317-7538 
primary 'Kunzle, C.A.'    15 ?                   
primary 'Smith, J.S.'     16 ?                   
primary 'Wang, J.'        17 ?                   
primary 'Kim, J.'         18 ?                   
primary 'Zhang, X.'       19 ?                   
primary 'Rockman, H.A.'   20 0000-0003-2921-1584 
primary 'Thomsen, A.R.B.' 21 0000-0003-1638-8911 
primary 'Rein, L.A.M.'    22 ?                   
primary 'Shi, L.'         23 0000-0002-4137-096X 
primary 'Ahn, S.'         24 0000-0001-5681-3789 
primary 'Masoudi, A.'     25 ?                   
primary 'Lefkowitz, R.J.' 26 0000-0003-1472-7545 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'anti-BRIL Fab Heavy chain'                                                                                 
23904.656 1 ? ?                    ? ? 
2 polymer     man 'anti-BRIL Fab Light chain'                                                                                 
23209.820 1 ? ?                    ? ? 
3 polymer     man 'Beta-arrestin-1,Soluble cytochrome b562'                                                                   
55727.160 1 ? 'M29W, H124I, R128L' ? ? 
4 non-polymer syn '(1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one' 
366.449   1 ? ?                    ? ? 
# 
_entity_name_com.entity_id   3 
_entity_name_com.name        'Arrestin beta-1,Cytochrome b-562' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
;
;EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
;
H ? 
2 'polypeptide(L)' no no 
;DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQP
EDFATYYCQQYLYYSLVTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
;
;DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQP
EDFATYYCQQYLYYSLVTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
;
L ? 
3 'polypeptide(L)' no no 
;LGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLF
VANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHK
RNSVRLVIRKVQYAPEADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHG
FDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVH
VTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTN
LASSTLLREGANREILGIIVSYKVKVKLVVSRGDYKDDDDKSDVAVELPFTLMHPKPKEEPPHREVPESETPVDTNLIEL
DTNDDDIVFEDFAR
;
;LGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLF
VANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHK
RNSVRLVIRKVQYAPEADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHG
FDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVH
VTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTN
LASSTLLREGANREILGIIVSYKVKVKLVVSRGDYKDDDDKSDVAVELPFTLMHPKPKEEPPHREVPESETPVDTNLIEL
DTNDDDIVFEDFAR
;
A ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        
'(1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one' 
_pdbx_entity_nonpoly.comp_id     ODN 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   VAL n 
1 3   GLN n 
1 4   LEU n 
1 5   VAL n 
1 6   GLU n 
1 7   SER n 
1 8   GLY n 
1 9   GLY n 
1 10  GLY n 
1 11  LEU n 
1 12  VAL n 
1 13  GLN n 
1 14  PRO n 
1 15  GLY n 
1 16  GLY n 
1 17  SER n 
1 18  LEU n 
1 19  ARG n 
1 20  LEU n 
1 21  SER n 
1 22  CYS n 
1 23  ALA n 
1 24  ALA n 
1 25  SER n 
1 26  GLY n 
1 27  PHE n 
1 28  ASN n 
1 29  VAL n 
1 30  VAL n 
1 31  ASP n 
1 32  PHE n 
1 33  SER n 
1 34  LEU n 
1 35  HIS n 
1 36  TRP n 
1 37  VAL n 
1 38  ARG n 
1 39  GLN n 
1 40  ALA n 
1 41  PRO n 
1 42  GLY n 
1 43  LYS n 
1 44  GLY n 
1 45  LEU n 
1 46  GLU n 
1 47  TRP n 
1 48  VAL n 
1 49  ALA n 
1 50  TYR n 
1 51  ILE n 
1 52  SER n 
1 53  SER n 
1 54  SER n 
1 55  SER n 
1 56  GLY n 
1 57  SER n 
1 58  THR n 
1 59  SER n 
1 60  TYR n 
1 61  ALA n 
1 62  ASP n 
1 63  SER n 
1 64  VAL n 
1 65  LYS n 
1 66  GLY n 
1 67  ARG n 
1 68  PHE n 
1 69  THR n 
1 70  ILE n 
1 71  SER n 
1 72  ALA n 
1 73  ASP n 
1 74  THR n 
1 75  SER n 
1 76  LYS n 
1 77  ASN n 
1 78  THR n 
1 79  ALA n 
1 80  TYR n 
1 81  LEU n 
1 82  GLN n 
1 83  MET n 
1 84  ASN n 
1 85  SER n 
1 86  LEU n 
1 87  ARG n 
1 88  ALA n 
1 89  GLU n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  VAL n 
1 94  TYR n 
1 95  TYR n 
1 96  CYS n 
1 97  ALA n 
1 98  ARG n 
1 99  TRP n 
1 100 GLY n 
1 101 TYR n 
1 102 TRP n 
1 103 PRO n 
1 104 GLY n 
1 105 GLU n 
1 106 PRO n 
1 107 TRP n 
1 108 TRP n 
1 109 LYS n 
1 110 ALA n 
1 111 PHE n 
1 112 ASP n 
1 113 TYR n 
1 114 TRP n 
1 115 GLY n 
1 116 GLN n 
1 117 GLY n 
1 118 THR n 
1 119 LEU n 
1 120 VAL n 
1 121 THR n 
1 122 VAL n 
1 123 SER n 
1 124 SER n 
1 125 ALA n 
1 126 SER n 
1 127 THR n 
1 128 LYS n 
1 129 GLY n 
1 130 PRO n 
1 131 SER n 
1 132 VAL n 
1 133 PHE n 
1 134 PRO n 
1 135 LEU n 
1 136 ALA n 
1 137 PRO n 
1 138 SER n 
1 139 SER n 
1 140 LYS n 
1 141 SER n 
1 142 THR n 
1 143 SER n 
1 144 GLY n 
1 145 GLY n 
1 146 THR n 
1 147 ALA n 
1 148 ALA n 
1 149 LEU n 
1 150 GLY n 
1 151 CYS n 
1 152 LEU n 
1 153 VAL n 
1 154 LYS n 
1 155 ASP n 
1 156 TYR n 
1 157 PHE n 
1 158 PRO n 
1 159 GLU n 
1 160 PRO n 
1 161 VAL n 
1 162 THR n 
1 163 VAL n 
1 164 SER n 
1 165 TRP n 
1 166 ASN n 
1 167 SER n 
1 168 GLY n 
1 169 ALA n 
1 170 LEU n 
1 171 THR n 
1 172 SER n 
1 173 GLY n 
1 174 VAL n 
1 175 HIS n 
1 176 THR n 
1 177 PHE n 
1 178 PRO n 
1 179 ALA n 
1 180 VAL n 
1 181 LEU n 
1 182 GLN n 
1 183 SER n 
1 184 SER n 
1 185 GLY n 
1 186 LEU n 
1 187 TYR n 
1 188 SER n 
1 189 LEU n 
1 190 SER n 
1 191 SER n 
1 192 VAL n 
1 193 VAL n 
1 194 THR n 
1 195 VAL n 
1 196 PRO n 
1 197 SER n 
1 198 SER n 
1 199 SER n 
1 200 LEU n 
1 201 GLY n 
1 202 THR n 
1 203 GLN n 
1 204 THR n 
1 205 TYR n 
1 206 ILE n 
1 207 CYS n 
1 208 ASN n 
1 209 VAL n 
1 210 ASN n 
1 211 HIS n 
1 212 LYS n 
1 213 PRO n 
1 214 SER n 
1 215 ASN n 
1 216 THR n 
1 217 LYS n 
1 218 VAL n 
1 219 ASP n 
1 220 LYS n 
1 221 LYS n 
1 222 VAL n 
1 223 GLU n 
1 224 PRO n 
1 225 LYS n 
2 1   ASP n 
2 2   ILE n 
2 3   GLN n 
2 4   MET n 
2 5   THR n 
2 6   GLN n 
2 7   SER n 
2 8   PRO n 
2 9   SER n 
2 10  SER n 
2 11  LEU n 
2 12  SER n 
2 13  ALA n 
2 14  SER n 
2 15  VAL n 
2 16  GLY n 
2 17  ASP n 
2 18  ARG n 
2 19  VAL n 
2 20  THR n 
2 21  ILE n 
2 22  THR n 
2 23  CYS n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  GLN n 
2 28  SER n 
2 29  VAL n 
2 30  SER n 
2 31  SER n 
2 32  ALA n 
2 33  VAL n 
2 34  ALA n 
2 35  TRP n 
2 36  TYR n 
2 37  GLN n 
2 38  GLN n 
2 39  LYS n 
2 40  PRO n 
2 41  GLY n 
2 42  LYS n 
2 43  ALA n 
2 44  PRO n 
2 45  LYS n 
2 46  LEU n 
2 47  LEU n 
2 48  ILE n 
2 49  TYR n 
2 50  SER n 
2 51  ALA n 
2 52  SER n 
2 53  SER n 
2 54  LEU n 
2 55  TYR n 
2 56  SER n 
2 57  GLY n 
2 58  VAL n 
2 59  PRO n 
2 60  SER n 
2 61  ARG n 
2 62  PHE n 
2 63  SER n 
2 64  GLY n 
2 65  SER n 
2 66  ARG n 
2 67  SER n 
2 68  GLY n 
2 69  THR n 
2 70  ASP n 
2 71  PHE n 
2 72  THR n 
2 73  LEU n 
2 74  THR n 
2 75  ILE n 
2 76  SER n 
2 77  SER n 
2 78  LEU n 
2 79  GLN n 
2 80  PRO n 
2 81  GLU n 
2 82  ASP n 
2 83  PHE n 
2 84  ALA n 
2 85  THR n 
2 86  TYR n 
2 87  TYR n 
2 88  CYS n 
2 89  GLN n 
2 90  GLN n 
2 91  TYR n 
2 92  LEU n 
2 93  TYR n 
2 94  TYR n 
2 95  SER n 
2 96  LEU n 
2 97  VAL n 
2 98  THR n 
2 99  PHE n 
2 100 GLY n 
2 101 GLN n 
2 102 GLY n 
2 103 THR n 
2 104 LYS n 
2 105 VAL n 
2 106 GLU n 
2 107 ILE n 
2 108 LYS n 
2 109 ARG n 
2 110 THR n 
2 111 VAL n 
2 112 ALA n 
2 113 ALA n 
2 114 PRO n 
2 115 SER n 
2 116 VAL n 
2 117 PHE n 
2 118 ILE n 
2 119 PHE n 
2 120 PRO n 
2 121 PRO n 
2 122 SER n 
2 123 ASP n 
2 124 SER n 
2 125 GLN n 
2 126 LEU n 
2 127 LYS n 
2 128 SER n 
2 129 GLY n 
2 130 THR n 
2 131 ALA n 
2 132 SER n 
2 133 VAL n 
2 134 VAL n 
2 135 CYS n 
2 136 LEU n 
2 137 LEU n 
2 138 ASN n 
2 139 ASN n 
2 140 PHE n 
2 141 TYR n 
2 142 PRO n 
2 143 ARG n 
2 144 GLU n 
2 145 ALA n 
2 146 LYS n 
2 147 VAL n 
2 148 GLN n 
2 149 TRP n 
2 150 LYS n 
2 151 VAL n 
2 152 ASP n 
2 153 ASN n 
2 154 ALA n 
2 155 LEU n 
2 156 GLN n 
2 157 SER n 
2 158 GLY n 
2 159 ASN n 
2 160 SER n 
2 161 GLN n 
2 162 GLU n 
2 163 SER n 
2 164 VAL n 
2 165 THR n 
2 166 GLU n 
2 167 GLN n 
2 168 ASP n 
2 169 SER n 
2 170 LYS n 
2 171 ASP n 
2 172 SER n 
2 173 THR n 
2 174 TYR n 
2 175 SER n 
2 176 LEU n 
2 177 SER n 
2 178 SER n 
2 179 THR n 
2 180 LEU n 
2 181 THR n 
2 182 LEU n 
2 183 SER n 
2 184 LYS n 
2 185 ALA n 
2 186 ASP n 
2 187 TYR n 
2 188 GLU n 
2 189 LYS n 
2 190 HIS n 
2 191 LYS n 
2 192 VAL n 
2 193 TYR n 
2 194 ALA n 
2 195 CYS n 
2 196 GLU n 
2 197 VAL n 
2 198 THR n 
2 199 HIS n 
2 200 GLN n 
2 201 GLY n 
2 202 LEU n 
2 203 SER n 
2 204 SER n 
2 205 PRO n 
2 206 VAL n 
2 207 THR n 
2 208 LYS n 
2 209 SER n 
2 210 PHE n 
2 211 ASN n 
2 212 ARG n 
3 1   LEU n 
3 2   GLY n 
3 3   ASP n 
3 4   LYS n 
3 5   GLY n 
3 6   THR n 
3 7   ARG n 
3 8   VAL n 
3 9   PHE n 
3 10  LYS n 
3 11  LYS n 
3 12  ALA n 
3 13  SER n 
3 14  PRO n 
3 15  ASN n 
3 16  GLY n 
3 17  LYS n 
3 18  LEU n 
3 19  THR n 
3 20  VAL n 
3 21  TYR n 
3 22  LEU n 
3 23  GLY n 
3 24  LYS n 
3 25  ARG n 
3 26  ASP n 
3 27  PHE n 
3 28  VAL n 
3 29  ASP n 
3 30  HIS n 
3 31  ILE n 
3 32  ASP n 
3 33  LEU n 
3 34  VAL n 
3 35  ASP n 
3 36  PRO n 
3 37  VAL n 
3 38  ASP n 
3 39  GLY n 
3 40  VAL n 
3 41  VAL n 
3 42  LEU n 
3 43  VAL n 
3 44  ASP n 
3 45  PRO n 
3 46  GLU n 
3 47  TYR n 
3 48  LEU n 
3 49  LYS n 
3 50  GLU n 
3 51  ARG n 
3 52  ARG n 
3 53  VAL n 
3 54  TYR n 
3 55  VAL n 
3 56  THR n 
3 57  LEU n 
3 58  THR n 
3 59  CYS n 
3 60  ALA n 
3 61  PHE n 
3 62  ARG n 
3 63  TYR n 
3 64  GLY n 
3 65  ARG n 
3 66  GLU n 
3 67  ASP n 
3 68  LEU n 
3 69  ASP n 
3 70  VAL n 
3 71  LEU n 
3 72  GLY n 
3 73  LEU n 
3 74  THR n 
3 75  PHE n 
3 76  ARG n 
3 77  LYS n 
3 78  ASP n 
3 79  LEU n 
3 80  PHE n 
3 81  VAL n 
3 82  ALA n 
3 83  ASN n 
3 84  VAL n 
3 85  GLN n 
3 86  SER n 
3 87  PHE n 
3 88  PRO n 
3 89  PRO n 
3 90  ALA n 
3 91  PRO n 
3 92  GLU n 
3 93  ASP n 
3 94  LYS n 
3 95  LYS n 
3 96  PRO n 
3 97  LEU n 
3 98  THR n 
3 99  ARG n 
3 100 LEU n 
3 101 GLN n 
3 102 GLU n 
3 103 ARG n 
3 104 LEU n 
3 105 ILE n 
3 106 LYS n 
3 107 LYS n 
3 108 LEU n 
3 109 GLY n 
3 110 GLU n 
3 111 HIS n 
3 112 ALA n 
3 113 TYR n 
3 114 PRO n 
3 115 PHE n 
3 116 THR n 
3 117 PHE n 
3 118 GLU n 
3 119 ILE n 
3 120 PRO n 
3 121 PRO n 
3 122 ASN n 
3 123 LEU n 
3 124 PRO n 
3 125 CYS n 
3 126 SER n 
3 127 VAL n 
3 128 THR n 
3 129 LEU n 
3 130 GLN n 
3 131 PRO n 
3 132 GLY n 
3 133 PRO n 
3 134 GLU n 
3 135 ASP n 
3 136 THR n 
3 137 GLY n 
3 138 LYS n 
3 139 ALA n 
3 140 CYS n 
3 141 GLY n 
3 142 VAL n 
3 143 ASP n 
3 144 TYR n 
3 145 GLU n 
3 146 VAL n 
3 147 LYS n 
3 148 ALA n 
3 149 PHE n 
3 150 CYS n 
3 151 ALA n 
3 152 GLU n 
3 153 ASN n 
3 154 LEU n 
3 155 GLU n 
3 156 GLU n 
3 157 LYS n 
3 158 ILE n 
3 159 HIS n 
3 160 LYS n 
3 161 ARG n 
3 162 ASN n 
3 163 SER n 
3 164 VAL n 
3 165 ARG n 
3 166 LEU n 
3 167 VAL n 
3 168 ILE n 
3 169 ARG n 
3 170 LYS n 
3 171 VAL n 
3 172 GLN n 
3 173 TYR n 
3 174 ALA n 
3 175 PRO n 
3 176 GLU n 
3 177 ALA n 
3 178 ASP n 
3 179 LEU n 
3 180 GLU n 
3 181 ASP n 
3 182 ASN n 
3 183 TRP n 
3 184 GLU n 
3 185 THR n 
3 186 LEU n 
3 187 ASN n 
3 188 ASP n 
3 189 ASN n 
3 190 LEU n 
3 191 LYS n 
3 192 VAL n 
3 193 ILE n 
3 194 GLU n 
3 195 LYS n 
3 196 ALA n 
3 197 ASP n 
3 198 ASN n 
3 199 ALA n 
3 200 ALA n 
3 201 GLN n 
3 202 VAL n 
3 203 LYS n 
3 204 ASP n 
3 205 ALA n 
3 206 LEU n 
3 207 THR n 
3 208 LYS n 
3 209 MET n 
3 210 ARG n 
3 211 ALA n 
3 212 ALA n 
3 213 ALA n 
3 214 LEU n 
3 215 ASP n 
3 216 ALA n 
3 217 GLN n 
3 218 LYS n 
3 219 ALA n 
3 220 THR n 
3 221 PRO n 
3 222 PRO n 
3 223 LYS n 
3 224 LEU n 
3 225 GLU n 
3 226 ASP n 
3 227 LYS n 
3 228 SER n 
3 229 PRO n 
3 230 ASP n 
3 231 SER n 
3 232 PRO n 
3 233 GLU n 
3 234 MET n 
3 235 LYS n 
3 236 ASP n 
3 237 PHE n 
3 238 ARG n 
3 239 HIS n 
3 240 GLY n 
3 241 PHE n 
3 242 ASP n 
3 243 ILE n 
3 244 LEU n 
3 245 VAL n 
3 246 GLY n 
3 247 GLN n 
3 248 ILE n 
3 249 ASP n 
3 250 ASP n 
3 251 ALA n 
3 252 LEU n 
3 253 LYS n 
3 254 LEU n 
3 255 ALA n 
3 256 ASN n 
3 257 GLU n 
3 258 GLY n 
3 259 LYS n 
3 260 VAL n 
3 261 LYS n 
3 262 GLU n 
3 263 ALA n 
3 264 GLN n 
3 265 ALA n 
3 266 ALA n 
3 267 ALA n 
3 268 GLU n 
3 269 GLN n 
3 270 LEU n 
3 271 LYS n 
3 272 THR n 
3 273 THR n 
3 274 ARG n 
3 275 ASN n 
3 276 ALA n 
3 277 TYR n 
3 278 ILE n 
3 279 GLN n 
3 280 LYS n 
3 281 TYR n 
3 282 LEU n 
3 283 PRO n 
3 284 THR n 
3 285 ALA n 
3 286 GLU n 
3 287 THR n 
3 288 THR n 
3 289 ARG n 
3 290 GLN n 
3 291 PHE n 
3 292 LEU n 
3 293 MET n 
3 294 SER n 
3 295 ASP n 
3 296 LYS n 
3 297 PRO n 
3 298 LEU n 
3 299 HIS n 
3 300 LEU n 
3 301 GLU n 
3 302 ALA n 
3 303 SER n 
3 304 LEU n 
3 305 ASP n 
3 306 LYS n 
3 307 GLU n 
3 308 ILE n 
3 309 TYR n 
3 310 TYR n 
3 311 HIS n 
3 312 GLY n 
3 313 GLU n 
3 314 PRO n 
3 315 ILE n 
3 316 SER n 
3 317 VAL n 
3 318 ASN n 
3 319 VAL n 
3 320 HIS n 
3 321 VAL n 
3 322 THR n 
3 323 ASN n 
3 324 ASN n 
3 325 THR n 
3 326 ASN n 
3 327 LYS n 
3 328 THR n 
3 329 VAL n 
3 330 LYS n 
3 331 LYS n 
3 332 ILE n 
3 333 LYS n 
3 334 ILE n 
3 335 SER n 
3 336 VAL n 
3 337 ARG n 
3 338 GLN n 
3 339 TYR n 
3 340 ALA n 
3 341 ASP n 
3 342 ILE n 
3 343 CYS n 
3 344 LEU n 
3 345 PHE n 
3 346 ASN n 
3 347 THR n 
3 348 ALA n 
3 349 GLN n 
3 350 TYR n 
3 351 LYS n 
3 352 CYS n 
3 353 PRO n 
3 354 VAL n 
3 355 ALA n 
3 356 MET n 
3 357 GLU n 
3 358 GLU n 
3 359 ALA n 
3 360 ASP n 
3 361 ASP n 
3 362 THR n 
3 363 VAL n 
3 364 ALA n 
3 365 PRO n 
3 366 SER n 
3 367 SER n 
3 368 THR n 
3 369 PHE n 
3 370 CYS n 
3 371 LYS n 
3 372 VAL n 
3 373 TYR n 
3 374 THR n 
3 375 LEU n 
3 376 THR n 
3 377 PRO n 
3 378 PHE n 
3 379 LEU n 
3 380 ALA n 
3 381 ASN n 
3 382 ASN n 
3 383 ARG n 
3 384 GLU n 
3 385 LYS n 
3 386 ARG n 
3 387 GLY n 
3 388 LEU n 
3 389 ALA n 
3 390 LEU n 
3 391 ASP n 
3 392 GLY n 
3 393 LYS n 
3 394 LEU n 
3 395 LYS n 
3 396 HIS n 
3 397 GLU n 
3 398 ASP n 
3 399 THR n 
3 400 ASN n 
3 401 LEU n 
3 402 ALA n 
3 403 SER n 
3 404 SER n 
3 405 THR n 
3 406 LEU n 
3 407 LEU n 
3 408 ARG n 
3 409 GLU n 
3 410 GLY n 
3 411 ALA n 
3 412 ASN n 
3 413 ARG n 
3 414 GLU n 
3 415 ILE n 
3 416 LEU n 
3 417 GLY n 
3 418 ILE n 
3 419 ILE n 
3 420 VAL n 
3 421 SER n 
3 422 TYR n 
3 423 LYS n 
3 424 VAL n 
3 425 LYS n 
3 426 VAL n 
3 427 LYS n 
3 428 LEU n 
3 429 VAL n 
3 430 VAL n 
3 431 SER n 
3 432 ARG n 
3 433 GLY n 
3 434 ASP n 
3 435 TYR n 
3 436 LYS n 
3 437 ASP n 
3 438 ASP n 
3 439 ASP n 
3 440 ASP n 
3 441 LYS n 
3 442 SER n 
3 443 ASP n 
3 444 VAL n 
3 445 ALA n 
3 446 VAL n 
3 447 GLU n 
3 448 LEU n 
3 449 PRO n 
3 450 PHE n 
3 451 THR n 
3 452 LEU n 
3 453 MET n 
3 454 HIS n 
3 455 PRO n 
3 456 LYS n 
3 457 PRO n 
3 458 LYS n 
3 459 GLU n 
3 460 GLU n 
3 461 PRO n 
3 462 PRO n 
3 463 HIS n 
3 464 ARG n 
3 465 GLU n 
3 466 VAL n 
3 467 PRO n 
3 468 GLU n 
3 469 SER n 
3 470 GLU n 
3 471 THR n 
3 472 PRO n 
3 473 VAL n 
3 474 ASP n 
3 475 THR n 
3 476 ASN n 
3 477 LEU n 
3 478 ILE n 
3 479 GLU n 
3 480 LEU n 
3 481 ASP n 
3 482 THR n 
3 483 ASN n 
3 484 ASP n 
3 485 ASP n 
3 486 ASP n 
3 487 ILE n 
3 488 VAL n 
3 489 PHE n 
3 490 GLU n 
3 491 ASP n 
3 492 PHE n 
3 493 ALA n 
3 494 ARG n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   225 ?            ? ?     ? ? ? ? ? ? 'Homo sapiens'      9606  ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1   212 ?            ? ?     ? ? ? ? ? ? 'Homo sapiens'      9606  ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1   176 'Norway rat' ? Arrb1 ? ? ? ? ? ? 'Rattus norvegicus' 10116 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 2 sample 'Biological sequence' 177 282 'Norway rat' ? cybC  ? ? ? ? ? ? 'Rattus norvegicus' 10116 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 3 sample 'Biological sequence' 283 494 'Norway rat' ? Arrb1 ? ? ? ? ? ? 'Rattus norvegicus' 10116 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
ODN non-polymer         . 
'(1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one' ? 'C20 H30 O6'     
366.449 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   4   4   GLU GLU H . n 
A 1 2   VAL 2   5   5   VAL VAL H . n 
A 1 3   GLN 3   6   6   GLN GLN H . n 
A 1 4   LEU 4   7   7   LEU LEU H . n 
A 1 5   VAL 5   8   8   VAL VAL H . n 
A 1 6   GLU 6   9   9   GLU GLU H . n 
A 1 7   SER 7   10  10  SER SER H . n 
A 1 8   GLY 8   11  11  GLY GLY H . n 
A 1 9   GLY 9   12  12  GLY GLY H . n 
A 1 10  GLY 10  13  13  GLY GLY H . n 
A 1 11  LEU 11  14  14  LEU LEU H . n 
A 1 12  VAL 12  15  15  VAL VAL H . n 
A 1 13  GLN 13  16  16  GLN GLN H . n 
A 1 14  PRO 14  17  17  PRO PRO H . n 
A 1 15  GLY 15  18  18  GLY GLY H . n 
A 1 16  GLY 16  19  19  GLY GLY H . n 
A 1 17  SER 17  20  20  SER SER H . n 
A 1 18  LEU 18  21  21  LEU LEU H . n 
A 1 19  ARG 19  22  22  ARG ARG H . n 
A 1 20  LEU 20  23  23  LEU LEU H . n 
A 1 21  SER 21  24  24  SER SER H . n 
A 1 22  CYS 22  25  25  CYS CYS H . n 
A 1 23  ALA 23  26  26  ALA ALA H . n 
A 1 24  ALA 24  27  27  ALA ALA H . n 
A 1 25  SER 25  28  28  SER SER H . n 
A 1 26  GLY 26  29  29  GLY GLY H . n 
A 1 27  PHE 27  30  30  PHE PHE H . n 
A 1 28  ASN 28  31  31  ASN ASN H . n 
A 1 29  VAL 29  32  32  VAL VAL H . n 
A 1 30  VAL 30  33  33  VAL VAL H . n 
A 1 31  ASP 31  34  34  ASP ASP H . n 
A 1 32  PHE 32  35  35  PHE PHE H . n 
A 1 33  SER 33  36  36  SER SER H . n 
A 1 34  LEU 34  37  37  LEU LEU H . n 
A 1 35  HIS 35  38  38  HIS HIS H . n 
A 1 36  TRP 36  39  39  TRP TRP H . n 
A 1 37  VAL 37  40  40  VAL VAL H . n 
A 1 38  ARG 38  41  41  ARG ARG H . n 
A 1 39  GLN 39  42  42  GLN GLN H . n 
A 1 40  ALA 40  43  43  ALA ALA H . n 
A 1 41  PRO 41  44  44  PRO PRO H . n 
A 1 42  GLY 42  45  45  GLY GLY H . n 
A 1 43  LYS 43  46  46  LYS LYS H . n 
A 1 44  GLY 44  47  47  GLY GLY H . n 
A 1 45  LEU 45  48  48  LEU LEU H . n 
A 1 46  GLU 46  49  49  GLU GLU H . n 
A 1 47  TRP 47  50  50  TRP TRP H . n 
A 1 48  VAL 48  51  51  VAL VAL H . n 
A 1 49  ALA 49  52  52  ALA ALA H . n 
A 1 50  TYR 50  53  53  TYR TYR H . n 
A 1 51  ILE 51  54  54  ILE ILE H . n 
A 1 52  SER 52  55  55  SER SER H . n 
A 1 53  SER 53  56  56  SER SER H . n 
A 1 54  SER 54  57  57  SER SER H . n 
A 1 55  SER 55  58  58  SER SER H . n 
A 1 56  GLY 56  59  59  GLY GLY H . n 
A 1 57  SER 57  60  60  SER SER H . n 
A 1 58  THR 58  61  61  THR THR H . n 
A 1 59  SER 59  62  62  SER SER H . n 
A 1 60  TYR 60  63  63  TYR TYR H . n 
A 1 61  ALA 61  64  64  ALA ALA H . n 
A 1 62  ASP 62  65  65  ASP ASP H . n 
A 1 63  SER 63  66  66  SER SER H . n 
A 1 64  VAL 64  67  67  VAL VAL H . n 
A 1 65  LYS 65  68  68  LYS LYS H . n 
A 1 66  GLY 66  69  69  GLY GLY H . n 
A 1 67  ARG 67  70  70  ARG ARG H . n 
A 1 68  PHE 68  71  71  PHE PHE H . n 
A 1 69  THR 69  72  72  THR THR H . n 
A 1 70  ILE 70  73  73  ILE ILE H . n 
A 1 71  SER 71  74  74  SER SER H . n 
A 1 72  ALA 72  75  75  ALA ALA H . n 
A 1 73  ASP 73  76  76  ASP ASP H . n 
A 1 74  THR 74  77  77  THR THR H . n 
A 1 75  SER 75  78  78  SER SER H . n 
A 1 76  LYS 76  79  79  LYS LYS H . n 
A 1 77  ASN 77  80  80  ASN ASN H . n 
A 1 78  THR 78  81  81  THR THR H . n 
A 1 79  ALA 79  82  82  ALA ALA H . n 
A 1 80  TYR 80  83  83  TYR TYR H . n 
A 1 81  LEU 81  84  84  LEU LEU H . n 
A 1 82  GLN 82  85  85  GLN GLN H . n 
A 1 83  MET 83  86  86  MET MET H . n 
A 1 84  ASN 84  87  87  ASN ASN H . n 
A 1 85  SER 85  88  88  SER SER H . n 
A 1 86  LEU 86  89  89  LEU LEU H . n 
A 1 87  ARG 87  90  90  ARG ARG H . n 
A 1 88  ALA 88  91  91  ALA ALA H . n 
A 1 89  GLU 89  92  92  GLU GLU H . n 
A 1 90  ASP 90  93  93  ASP ASP H . n 
A 1 91  THR 91  94  94  THR THR H . n 
A 1 92  ALA 92  95  95  ALA ALA H . n 
A 1 93  VAL 93  96  96  VAL VAL H . n 
A 1 94  TYR 94  97  97  TYR TYR H . n 
A 1 95  TYR 95  98  98  TYR TYR H . n 
A 1 96  CYS 96  99  99  CYS CYS H . n 
A 1 97  ALA 97  100 100 ALA ALA H . n 
A 1 98  ARG 98  101 101 ARG ARG H . n 
A 1 99  TRP 99  102 102 TRP TRP H . n 
A 1 100 GLY 100 103 103 GLY GLY H . n 
A 1 101 TYR 101 104 104 TYR TYR H . n 
A 1 102 TRP 102 105 105 TRP TRP H . n 
A 1 103 PRO 103 106 106 PRO PRO H . n 
A 1 104 GLY 104 107 107 GLY GLY H . n 
A 1 105 GLU 105 108 108 GLU GLU H . n 
A 1 106 PRO 106 109 109 PRO PRO H . n 
A 1 107 TRP 107 110 110 TRP TRP H . n 
A 1 108 TRP 108 111 111 TRP TRP H . n 
A 1 109 LYS 109 112 112 LYS LYS H . n 
A 1 110 ALA 110 113 113 ALA ALA H . n 
A 1 111 PHE 111 114 114 PHE PHE H . n 
A 1 112 ASP 112 115 115 ASP ASP H . n 
A 1 113 TYR 113 116 116 TYR TYR H . n 
A 1 114 TRP 114 117 117 TRP TRP H . n 
A 1 115 GLY 115 118 118 GLY GLY H . n 
A 1 116 GLN 116 119 119 GLN GLN H . n 
A 1 117 GLY 117 120 120 GLY GLY H . n 
A 1 118 THR 118 121 121 THR THR H . n 
A 1 119 LEU 119 122 122 LEU LEU H . n 
A 1 120 VAL 120 123 123 VAL VAL H . n 
A 1 121 THR 121 124 124 THR THR H . n 
A 1 122 VAL 122 125 125 VAL VAL H . n 
A 1 123 SER 123 126 126 SER SER H . n 
A 1 124 SER 124 127 127 SER SER H . n 
A 1 125 ALA 125 128 128 ALA ALA H . n 
A 1 126 SER 126 129 ?   ?   ?   H . n 
A 1 127 THR 127 130 ?   ?   ?   H . n 
A 1 128 LYS 128 131 ?   ?   ?   H . n 
A 1 129 GLY 129 132 ?   ?   ?   H . n 
A 1 130 PRO 130 133 ?   ?   ?   H . n 
A 1 131 SER 131 134 ?   ?   ?   H . n 
A 1 132 VAL 132 135 ?   ?   ?   H . n 
A 1 133 PHE 133 136 ?   ?   ?   H . n 
A 1 134 PRO 134 137 ?   ?   ?   H . n 
A 1 135 LEU 135 138 ?   ?   ?   H . n 
A 1 136 ALA 136 139 ?   ?   ?   H . n 
A 1 137 PRO 137 140 ?   ?   ?   H . n 
A 1 138 SER 138 141 ?   ?   ?   H . n 
A 1 139 SER 139 142 ?   ?   ?   H . n 
A 1 140 LYS 140 143 ?   ?   ?   H . n 
A 1 141 SER 141 144 ?   ?   ?   H . n 
A 1 142 THR 142 145 ?   ?   ?   H . n 
A 1 143 SER 143 146 ?   ?   ?   H . n 
A 1 144 GLY 144 147 ?   ?   ?   H . n 
A 1 145 GLY 145 148 ?   ?   ?   H . n 
A 1 146 THR 146 149 ?   ?   ?   H . n 
A 1 147 ALA 147 150 ?   ?   ?   H . n 
A 1 148 ALA 148 151 ?   ?   ?   H . n 
A 1 149 LEU 149 152 ?   ?   ?   H . n 
A 1 150 GLY 150 153 ?   ?   ?   H . n 
A 1 151 CYS 151 154 ?   ?   ?   H . n 
A 1 152 LEU 152 155 ?   ?   ?   H . n 
A 1 153 VAL 153 156 ?   ?   ?   H . n 
A 1 154 LYS 154 157 ?   ?   ?   H . n 
A 1 155 ASP 155 158 ?   ?   ?   H . n 
A 1 156 TYR 156 159 ?   ?   ?   H . n 
A 1 157 PHE 157 160 ?   ?   ?   H . n 
A 1 158 PRO 158 161 ?   ?   ?   H . n 
A 1 159 GLU 159 162 ?   ?   ?   H . n 
A 1 160 PRO 160 163 ?   ?   ?   H . n 
A 1 161 VAL 161 164 ?   ?   ?   H . n 
A 1 162 THR 162 165 ?   ?   ?   H . n 
A 1 163 VAL 163 166 ?   ?   ?   H . n 
A 1 164 SER 164 167 ?   ?   ?   H . n 
A 1 165 TRP 165 168 ?   ?   ?   H . n 
A 1 166 ASN 166 169 ?   ?   ?   H . n 
A 1 167 SER 167 170 ?   ?   ?   H . n 
A 1 168 GLY 168 171 ?   ?   ?   H . n 
A 1 169 ALA 169 172 ?   ?   ?   H . n 
A 1 170 LEU 170 173 ?   ?   ?   H . n 
A 1 171 THR 171 174 ?   ?   ?   H . n 
A 1 172 SER 172 175 ?   ?   ?   H . n 
A 1 173 GLY 173 176 ?   ?   ?   H . n 
A 1 174 VAL 174 177 ?   ?   ?   H . n 
A 1 175 HIS 175 178 ?   ?   ?   H . n 
A 1 176 THR 176 179 ?   ?   ?   H . n 
A 1 177 PHE 177 180 ?   ?   ?   H . n 
A 1 178 PRO 178 181 ?   ?   ?   H . n 
A 1 179 ALA 179 182 ?   ?   ?   H . n 
A 1 180 VAL 180 183 ?   ?   ?   H . n 
A 1 181 LEU 181 184 ?   ?   ?   H . n 
A 1 182 GLN 182 185 ?   ?   ?   H . n 
A 1 183 SER 183 186 ?   ?   ?   H . n 
A 1 184 SER 184 187 ?   ?   ?   H . n 
A 1 185 GLY 185 188 ?   ?   ?   H . n 
A 1 186 LEU 186 189 ?   ?   ?   H . n 
A 1 187 TYR 187 190 ?   ?   ?   H . n 
A 1 188 SER 188 191 ?   ?   ?   H . n 
A 1 189 LEU 189 192 ?   ?   ?   H . n 
A 1 190 SER 190 193 ?   ?   ?   H . n 
A 1 191 SER 191 194 ?   ?   ?   H . n 
A 1 192 VAL 192 195 ?   ?   ?   H . n 
A 1 193 VAL 193 196 ?   ?   ?   H . n 
A 1 194 THR 194 197 ?   ?   ?   H . n 
A 1 195 VAL 195 198 ?   ?   ?   H . n 
A 1 196 PRO 196 199 ?   ?   ?   H . n 
A 1 197 SER 197 200 ?   ?   ?   H . n 
A 1 198 SER 198 201 ?   ?   ?   H . n 
A 1 199 SER 199 202 ?   ?   ?   H . n 
A 1 200 LEU 200 203 ?   ?   ?   H . n 
A 1 201 GLY 201 204 ?   ?   ?   H . n 
A 1 202 THR 202 205 ?   ?   ?   H . n 
A 1 203 GLN 203 206 ?   ?   ?   H . n 
A 1 204 THR 204 207 ?   ?   ?   H . n 
A 1 205 TYR 205 208 ?   ?   ?   H . n 
A 1 206 ILE 206 209 ?   ?   ?   H . n 
A 1 207 CYS 207 210 ?   ?   ?   H . n 
A 1 208 ASN 208 211 ?   ?   ?   H . n 
A 1 209 VAL 209 212 ?   ?   ?   H . n 
A 1 210 ASN 210 213 ?   ?   ?   H . n 
A 1 211 HIS 211 214 ?   ?   ?   H . n 
A 1 212 LYS 212 215 ?   ?   ?   H . n 
A 1 213 PRO 213 216 ?   ?   ?   H . n 
A 1 214 SER 214 217 ?   ?   ?   H . n 
A 1 215 ASN 215 218 ?   ?   ?   H . n 
A 1 216 THR 216 219 ?   ?   ?   H . n 
A 1 217 LYS 217 220 ?   ?   ?   H . n 
A 1 218 VAL 218 221 ?   ?   ?   H . n 
A 1 219 ASP 219 222 ?   ?   ?   H . n 
A 1 220 LYS 220 223 ?   ?   ?   H . n 
A 1 221 LYS 221 224 ?   ?   ?   H . n 
A 1 222 VAL 222 225 ?   ?   ?   H . n 
A 1 223 GLU 223 226 ?   ?   ?   H . n 
A 1 224 PRO 224 227 ?   ?   ?   H . n 
A 1 225 LYS 225 228 ?   ?   ?   H . n 
B 2 1   ASP 1   2   2   ASP ASP L . n 
B 2 2   ILE 2   3   3   ILE ILE L . n 
B 2 3   GLN 3   4   4   GLN GLN L . n 
B 2 4   MET 4   5   5   MET MET L . n 
B 2 5   THR 5   6   6   THR THR L . n 
B 2 6   GLN 6   7   7   GLN GLN L . n 
B 2 7   SER 7   8   8   SER SER L . n 
B 2 8   PRO 8   9   9   PRO PRO L . n 
B 2 9   SER 9   10  10  SER SER L . n 
B 2 10  SER 10  11  11  SER SER L . n 
B 2 11  LEU 11  12  12  LEU LEU L . n 
B 2 12  SER 12  13  13  SER SER L . n 
B 2 13  ALA 13  14  14  ALA ALA L . n 
B 2 14  SER 14  15  15  SER SER L . n 
B 2 15  VAL 15  16  16  VAL VAL L . n 
B 2 16  GLY 16  17  17  GLY GLY L . n 
B 2 17  ASP 17  18  18  ASP ASP L . n 
B 2 18  ARG 18  19  19  ARG ARG L . n 
B 2 19  VAL 19  20  20  VAL VAL L . n 
B 2 20  THR 20  21  21  THR THR L . n 
B 2 21  ILE 21  22  22  ILE ILE L . n 
B 2 22  THR 22  23  23  THR THR L . n 
B 2 23  CYS 23  24  24  CYS CYS L . n 
B 2 24  ARG 24  25  25  ARG ARG L . n 
B 2 25  ALA 25  26  26  ALA ALA L . n 
B 2 26  SER 26  27  27  SER SER L . n 
B 2 27  GLN 27  28  28  GLN GLN L . n 
B 2 28  SER 28  29  29  SER SER L . n 
B 2 29  VAL 29  30  30  VAL VAL L . n 
B 2 30  SER 30  31  31  SER SER L . n 
B 2 31  SER 31  32  32  SER SER L . n 
B 2 32  ALA 32  33  33  ALA ALA L . n 
B 2 33  VAL 33  34  34  VAL VAL L . n 
B 2 34  ALA 34  35  35  ALA ALA L . n 
B 2 35  TRP 35  36  36  TRP TRP L . n 
B 2 36  TYR 36  37  37  TYR TYR L . n 
B 2 37  GLN 37  38  38  GLN GLN L . n 
B 2 38  GLN 38  39  39  GLN GLN L . n 
B 2 39  LYS 39  40  40  LYS LYS L . n 
B 2 40  PRO 40  41  41  PRO PRO L . n 
B 2 41  GLY 41  42  42  GLY GLY L . n 
B 2 42  LYS 42  43  43  LYS LYS L . n 
B 2 43  ALA 43  44  44  ALA ALA L . n 
B 2 44  PRO 44  45  45  PRO PRO L . n 
B 2 45  LYS 45  46  46  LYS LYS L . n 
B 2 46  LEU 46  47  47  LEU LEU L . n 
B 2 47  LEU 47  48  48  LEU LEU L . n 
B 2 48  ILE 48  49  49  ILE ILE L . n 
B 2 49  TYR 49  50  50  TYR TYR L . n 
B 2 50  SER 50  51  51  SER SER L . n 
B 2 51  ALA 51  52  52  ALA ALA L . n 
B 2 52  SER 52  53  53  SER SER L . n 
B 2 53  SER 53  54  54  SER SER L . n 
B 2 54  LEU 54  55  55  LEU LEU L . n 
B 2 55  TYR 55  56  56  TYR TYR L . n 
B 2 56  SER 56  57  57  SER SER L . n 
B 2 57  GLY 57  58  58  GLY GLY L . n 
B 2 58  VAL 58  59  59  VAL VAL L . n 
B 2 59  PRO 59  60  60  PRO PRO L . n 
B 2 60  SER 60  61  61  SER SER L . n 
B 2 61  ARG 61  62  62  ARG ARG L . n 
B 2 62  PHE 62  63  63  PHE PHE L . n 
B 2 63  SER 63  64  64  SER SER L . n 
B 2 64  GLY 64  65  65  GLY GLY L . n 
B 2 65  SER 65  66  66  SER SER L . n 
B 2 66  ARG 66  67  67  ARG ARG L . n 
B 2 67  SER 67  68  68  SER SER L . n 
B 2 68  GLY 68  69  69  GLY GLY L . n 
B 2 69  THR 69  70  70  THR THR L . n 
B 2 70  ASP 70  71  71  ASP ASP L . n 
B 2 71  PHE 71  72  72  PHE PHE L . n 
B 2 72  THR 72  73  73  THR THR L . n 
B 2 73  LEU 73  74  74  LEU LEU L . n 
B 2 74  THR 74  75  75  THR THR L . n 
B 2 75  ILE 75  76  76  ILE ILE L . n 
B 2 76  SER 76  77  77  SER SER L . n 
B 2 77  SER 77  78  78  SER SER L . n 
B 2 78  LEU 78  79  79  LEU LEU L . n 
B 2 79  GLN 79  80  80  GLN GLN L . n 
B 2 80  PRO 80  81  81  PRO PRO L . n 
B 2 81  GLU 81  82  82  GLU GLU L . n 
B 2 82  ASP 82  83  83  ASP ASP L . n 
B 2 83  PHE 83  84  84  PHE PHE L . n 
B 2 84  ALA 84  85  85  ALA ALA L . n 
B 2 85  THR 85  86  86  THR THR L . n 
B 2 86  TYR 86  87  87  TYR TYR L . n 
B 2 87  TYR 87  88  88  TYR TYR L . n 
B 2 88  CYS 88  89  89  CYS CYS L . n 
B 2 89  GLN 89  90  90  GLN GLN L . n 
B 2 90  GLN 90  91  91  GLN GLN L . n 
B 2 91  TYR 91  92  92  TYR TYR L . n 
B 2 92  LEU 92  93  93  LEU LEU L . n 
B 2 93  TYR 93  94  94  TYR TYR L . n 
B 2 94  TYR 94  95  95  TYR TYR L . n 
B 2 95  SER 95  96  96  SER SER L . n 
B 2 96  LEU 96  97  97  LEU LEU L . n 
B 2 97  VAL 97  98  98  VAL VAL L . n 
B 2 98  THR 98  99  99  THR THR L . n 
B 2 99  PHE 99  100 100 PHE PHE L . n 
B 2 100 GLY 100 101 101 GLY GLY L . n 
B 2 101 GLN 101 102 102 GLN GLN L . n 
B 2 102 GLY 102 103 103 GLY GLY L . n 
B 2 103 THR 103 104 104 THR THR L . n 
B 2 104 LYS 104 105 105 LYS LYS L . n 
B 2 105 VAL 105 106 106 VAL VAL L . n 
B 2 106 GLU 106 107 107 GLU GLU L . n 
B 2 107 ILE 107 108 108 ILE ILE L . n 
B 2 108 LYS 108 109 109 LYS LYS L . n 
B 2 109 ARG 109 110 ?   ?   ?   L . n 
B 2 110 THR 110 111 ?   ?   ?   L . n 
B 2 111 VAL 111 112 ?   ?   ?   L . n 
B 2 112 ALA 112 113 ?   ?   ?   L . n 
B 2 113 ALA 113 114 ?   ?   ?   L . n 
B 2 114 PRO 114 115 ?   ?   ?   L . n 
B 2 115 SER 115 116 ?   ?   ?   L . n 
B 2 116 VAL 116 117 ?   ?   ?   L . n 
B 2 117 PHE 117 118 ?   ?   ?   L . n 
B 2 118 ILE 118 119 ?   ?   ?   L . n 
B 2 119 PHE 119 120 ?   ?   ?   L . n 
B 2 120 PRO 120 121 ?   ?   ?   L . n 
B 2 121 PRO 121 122 ?   ?   ?   L . n 
B 2 122 SER 122 123 ?   ?   ?   L . n 
B 2 123 ASP 123 124 ?   ?   ?   L . n 
B 2 124 SER 124 125 ?   ?   ?   L . n 
B 2 125 GLN 125 126 ?   ?   ?   L . n 
B 2 126 LEU 126 127 ?   ?   ?   L . n 
B 2 127 LYS 127 128 ?   ?   ?   L . n 
B 2 128 SER 128 129 ?   ?   ?   L . n 
B 2 129 GLY 129 130 ?   ?   ?   L . n 
B 2 130 THR 130 131 ?   ?   ?   L . n 
B 2 131 ALA 131 132 ?   ?   ?   L . n 
B 2 132 SER 132 133 ?   ?   ?   L . n 
B 2 133 VAL 133 134 ?   ?   ?   L . n 
B 2 134 VAL 134 135 ?   ?   ?   L . n 
B 2 135 CYS 135 136 ?   ?   ?   L . n 
B 2 136 LEU 136 137 ?   ?   ?   L . n 
B 2 137 LEU 137 138 ?   ?   ?   L . n 
B 2 138 ASN 138 139 ?   ?   ?   L . n 
B 2 139 ASN 139 140 ?   ?   ?   L . n 
B 2 140 PHE 140 141 ?   ?   ?   L . n 
B 2 141 TYR 141 142 ?   ?   ?   L . n 
B 2 142 PRO 142 143 ?   ?   ?   L . n 
B 2 143 ARG 143 144 ?   ?   ?   L . n 
B 2 144 GLU 144 145 ?   ?   ?   L . n 
B 2 145 ALA 145 146 ?   ?   ?   L . n 
B 2 146 LYS 146 147 ?   ?   ?   L . n 
B 2 147 VAL 147 148 ?   ?   ?   L . n 
B 2 148 GLN 148 149 ?   ?   ?   L . n 
B 2 149 TRP 149 150 ?   ?   ?   L . n 
B 2 150 LYS 150 151 ?   ?   ?   L . n 
B 2 151 VAL 151 152 ?   ?   ?   L . n 
B 2 152 ASP 152 153 ?   ?   ?   L . n 
B 2 153 ASN 153 154 ?   ?   ?   L . n 
B 2 154 ALA 154 155 ?   ?   ?   L . n 
B 2 155 LEU 155 156 ?   ?   ?   L . n 
B 2 156 GLN 156 157 ?   ?   ?   L . n 
B 2 157 SER 157 158 ?   ?   ?   L . n 
B 2 158 GLY 158 159 ?   ?   ?   L . n 
B 2 159 ASN 159 160 ?   ?   ?   L . n 
B 2 160 SER 160 161 ?   ?   ?   L . n 
B 2 161 GLN 161 162 ?   ?   ?   L . n 
B 2 162 GLU 162 163 ?   ?   ?   L . n 
B 2 163 SER 163 164 ?   ?   ?   L . n 
B 2 164 VAL 164 165 ?   ?   ?   L . n 
B 2 165 THR 165 166 ?   ?   ?   L . n 
B 2 166 GLU 166 167 ?   ?   ?   L . n 
B 2 167 GLN 167 168 ?   ?   ?   L . n 
B 2 168 ASP 168 169 ?   ?   ?   L . n 
B 2 169 SER 169 170 ?   ?   ?   L . n 
B 2 170 LYS 170 171 ?   ?   ?   L . n 
B 2 171 ASP 171 172 ?   ?   ?   L . n 
B 2 172 SER 172 173 ?   ?   ?   L . n 
B 2 173 THR 173 174 ?   ?   ?   L . n 
B 2 174 TYR 174 175 ?   ?   ?   L . n 
B 2 175 SER 175 176 ?   ?   ?   L . n 
B 2 176 LEU 176 177 ?   ?   ?   L . n 
B 2 177 SER 177 178 ?   ?   ?   L . n 
B 2 178 SER 178 179 ?   ?   ?   L . n 
B 2 179 THR 179 180 ?   ?   ?   L . n 
B 2 180 LEU 180 181 ?   ?   ?   L . n 
B 2 181 THR 181 182 ?   ?   ?   L . n 
B 2 182 LEU 182 183 ?   ?   ?   L . n 
B 2 183 SER 183 184 ?   ?   ?   L . n 
B 2 184 LYS 184 185 ?   ?   ?   L . n 
B 2 185 ALA 185 186 ?   ?   ?   L . n 
B 2 186 ASP 186 187 ?   ?   ?   L . n 
B 2 187 TYR 187 188 ?   ?   ?   L . n 
B 2 188 GLU 188 189 ?   ?   ?   L . n 
B 2 189 LYS 189 190 ?   ?   ?   L . n 
B 2 190 HIS 190 191 ?   ?   ?   L . n 
B 2 191 LYS 191 192 ?   ?   ?   L . n 
B 2 192 VAL 192 193 ?   ?   ?   L . n 
B 2 193 TYR 193 194 ?   ?   ?   L . n 
B 2 194 ALA 194 195 ?   ?   ?   L . n 
B 2 195 CYS 195 196 ?   ?   ?   L . n 
B 2 196 GLU 196 197 ?   ?   ?   L . n 
B 2 197 VAL 197 198 ?   ?   ?   L . n 
B 2 198 THR 198 199 ?   ?   ?   L . n 
B 2 199 HIS 199 200 ?   ?   ?   L . n 
B 2 200 GLN 200 201 ?   ?   ?   L . n 
B 2 201 GLY 201 202 ?   ?   ?   L . n 
B 2 202 LEU 202 203 ?   ?   ?   L . n 
B 2 203 SER 203 204 ?   ?   ?   L . n 
B 2 204 SER 204 205 ?   ?   ?   L . n 
B 2 205 PRO 205 206 ?   ?   ?   L . n 
B 2 206 VAL 206 207 ?   ?   ?   L . n 
B 2 207 THR 207 208 ?   ?   ?   L . n 
B 2 208 LYS 208 209 ?   ?   ?   L . n 
B 2 209 SER 209 210 ?   ?   ?   L . n 
B 2 210 PHE 210 211 ?   ?   ?   L . n 
B 2 211 ASN 211 212 ?   ?   ?   L . n 
B 2 212 ARG 212 213 ?   ?   ?   L . n 
C 3 1   LEU 1   1   ?   ?   ?   A . n 
C 3 2   GLY 2   2   ?   ?   ?   A . n 
C 3 3   ASP 3   3   ?   ?   ?   A . n 
C 3 4   LYS 4   4   ?   ?   ?   A . n 
C 3 5   GLY 5   5   ?   ?   ?   A . n 
C 3 6   THR 6   6   6   THR THR A . n 
C 3 7   ARG 7   7   7   ARG ARG A . n 
C 3 8   VAL 8   8   8   VAL VAL A . n 
C 3 9   PHE 9   9   9   PHE PHE A . n 
C 3 10  LYS 10  10  10  LYS LYS A . n 
C 3 11  LYS 11  11  11  LYS LYS A . n 
C 3 12  ALA 12  12  12  ALA ALA A . n 
C 3 13  SER 13  13  13  SER SER A . n 
C 3 14  PRO 14  14  14  PRO PRO A . n 
C 3 15  ASN 15  15  15  ASN ASN A . n 
C 3 16  GLY 16  16  16  GLY GLY A . n 
C 3 17  LYS 17  17  17  LYS LYS A . n 
C 3 18  LEU 18  18  18  LEU LEU A . n 
C 3 19  THR 19  19  19  THR THR A . n 
C 3 20  VAL 20  20  20  VAL VAL A . n 
C 3 21  TYR 21  21  21  TYR TYR A . n 
C 3 22  LEU 22  22  22  LEU LEU A . n 
C 3 23  GLY 23  23  23  GLY GLY A . n 
C 3 24  LYS 24  24  24  LYS LYS A . n 
C 3 25  ARG 25  25  25  ARG ARG A . n 
C 3 26  ASP 26  26  26  ASP ASP A . n 
C 3 27  PHE 27  27  27  PHE PHE A . n 
C 3 28  VAL 28  28  28  VAL VAL A . n 
C 3 29  ASP 29  29  29  ASP ASP A . n 
C 3 30  HIS 30  30  30  HIS HIS A . n 
C 3 31  ILE 31  31  31  ILE ILE A . n 
C 3 32  ASP 32  32  32  ASP ASP A . n 
C 3 33  LEU 33  33  33  LEU LEU A . n 
C 3 34  VAL 34  34  34  VAL VAL A . n 
C 3 35  ASP 35  35  35  ASP ASP A . n 
C 3 36  PRO 36  36  36  PRO PRO A . n 
C 3 37  VAL 37  37  37  VAL VAL A . n 
C 3 38  ASP 38  38  38  ASP ASP A . n 
C 3 39  GLY 39  39  39  GLY GLY A . n 
C 3 40  VAL 40  40  40  VAL VAL A . n 
C 3 41  VAL 41  41  41  VAL VAL A . n 
C 3 42  LEU 42  42  42  LEU LEU A . n 
C 3 43  VAL 43  43  43  VAL VAL A . n 
C 3 44  ASP 44  44  44  ASP ASP A . n 
C 3 45  PRO 45  45  45  PRO PRO A . n 
C 3 46  GLU 46  46  46  GLU GLU A . n 
C 3 47  TYR 47  47  47  TYR TYR A . n 
C 3 48  LEU 48  48  48  LEU LEU A . n 
C 3 49  LYS 49  49  49  LYS LYS A . n 
C 3 50  GLU 50  50  50  GLU GLU A . n 
C 3 51  ARG 51  51  51  ARG ARG A . n 
C 3 52  ARG 52  52  52  ARG ARG A . n 
C 3 53  VAL 53  53  53  VAL VAL A . n 
C 3 54  TYR 54  54  54  TYR TYR A . n 
C 3 55  VAL 55  55  55  VAL VAL A . n 
C 3 56  THR 56  56  56  THR THR A . n 
C 3 57  LEU 57  57  57  LEU LEU A . n 
C 3 58  THR 58  58  58  THR THR A . n 
C 3 59  CYS 59  59  59  CYS CYS A . n 
C 3 60  ALA 60  60  60  ALA ALA A . n 
C 3 61  PHE 61  61  61  PHE PHE A . n 
C 3 62  ARG 62  62  62  ARG ARG A . n 
C 3 63  TYR 63  63  ?   ?   ?   A . n 
C 3 64  GLY 64  64  ?   ?   ?   A . n 
C 3 65  ARG 65  65  ?   ?   ?   A . n 
C 3 66  GLU 66  66  ?   ?   ?   A . n 
C 3 67  ASP 67  67  ?   ?   ?   A . n 
C 3 68  LEU 68  68  ?   ?   ?   A . n 
C 3 69  ASP 69  69  ?   ?   ?   A . n 
C 3 70  VAL 70  70  ?   ?   ?   A . n 
C 3 71  LEU 71  71  ?   ?   ?   A . n 
C 3 72  GLY 72  72  ?   ?   ?   A . n 
C 3 73  LEU 73  73  ?   ?   ?   A . n 
C 3 74  THR 74  74  74  THR THR A . n 
C 3 75  PHE 75  75  75  PHE PHE A . n 
C 3 76  ARG 76  76  76  ARG ARG A . n 
C 3 77  LYS 77  77  77  LYS LYS A . n 
C 3 78  ASP 78  78  78  ASP ASP A . n 
C 3 79  LEU 79  79  79  LEU LEU A . n 
C 3 80  PHE 80  80  80  PHE PHE A . n 
C 3 81  VAL 81  81  81  VAL VAL A . n 
C 3 82  ALA 82  82  82  ALA ALA A . n 
C 3 83  ASN 83  83  83  ASN ASN A . n 
C 3 84  VAL 84  84  84  VAL VAL A . n 
C 3 85  GLN 85  85  85  GLN GLN A . n 
C 3 86  SER 86  86  86  SER SER A . n 
C 3 87  PHE 87  87  87  PHE PHE A . n 
C 3 88  PRO 88  88  88  PRO PRO A . n 
C 3 89  PRO 89  89  89  PRO PRO A . n 
C 3 90  ALA 90  90  90  ALA ALA A . n 
C 3 91  PRO 91  91  91  PRO PRO A . n 
C 3 92  GLU 92  92  92  GLU GLU A . n 
C 3 93  ASP 93  93  93  ASP ASP A . n 
C 3 94  LYS 94  94  94  LYS LYS A . n 
C 3 95  LYS 95  95  95  LYS LYS A . n 
C 3 96  PRO 96  96  96  PRO PRO A . n 
C 3 97  LEU 97  97  97  LEU LEU A . n 
C 3 98  THR 98  98  98  THR THR A . n 
C 3 99  ARG 99  99  99  ARG ARG A . n 
C 3 100 LEU 100 100 100 LEU LEU A . n 
C 3 101 GLN 101 101 101 GLN GLN A . n 
C 3 102 GLU 102 102 102 GLU GLU A . n 
C 3 103 ARG 103 103 103 ARG ARG A . n 
C 3 104 LEU 104 104 104 LEU LEU A . n 
C 3 105 ILE 105 105 105 ILE ILE A . n 
C 3 106 LYS 106 106 106 LYS LYS A . n 
C 3 107 LYS 107 107 107 LYS LYS A . n 
C 3 108 LEU 108 108 108 LEU LEU A . n 
C 3 109 GLY 109 109 109 GLY GLY A . n 
C 3 110 GLU 110 110 110 GLU GLU A . n 
C 3 111 HIS 111 111 111 HIS HIS A . n 
C 3 112 ALA 112 112 112 ALA ALA A . n 
C 3 113 TYR 113 113 113 TYR TYR A . n 
C 3 114 PRO 114 114 114 PRO PRO A . n 
C 3 115 PHE 115 115 115 PHE PHE A . n 
C 3 116 THR 116 116 116 THR THR A . n 
C 3 117 PHE 117 117 117 PHE PHE A . n 
C 3 118 GLU 118 118 118 GLU GLU A . n 
C 3 119 ILE 119 119 119 ILE ILE A . n 
C 3 120 PRO 120 120 120 PRO PRO A . n 
C 3 121 PRO 121 121 121 PRO PRO A . n 
C 3 122 ASN 122 122 122 ASN ASN A . n 
C 3 123 LEU 123 123 123 LEU LEU A . n 
C 3 124 PRO 124 124 124 PRO PRO A . n 
C 3 125 CYS 125 125 125 CYS CYS A . n 
C 3 126 SER 126 126 126 SER SER A . n 
C 3 127 VAL 127 127 127 VAL VAL A . n 
C 3 128 THR 128 128 128 THR THR A . n 
C 3 129 LEU 129 129 129 LEU LEU A . n 
C 3 130 GLN 130 130 130 GLN GLN A . n 
C 3 131 PRO 131 131 131 PRO PRO A . n 
C 3 132 GLY 132 132 132 GLY GLY A . n 
C 3 133 PRO 133 133 133 PRO PRO A . n 
C 3 134 GLU 134 134 134 GLU GLU A . n 
C 3 135 ASP 135 135 135 ASP ASP A . n 
C 3 136 THR 136 136 136 THR THR A . n 
C 3 137 GLY 137 137 137 GLY GLY A . n 
C 3 138 LYS 138 138 138 LYS LYS A . n 
C 3 139 ALA 139 139 139 ALA ALA A . n 
C 3 140 CYS 140 140 140 CYS CYS A . n 
C 3 141 GLY 141 141 141 GLY GLY A . n 
C 3 142 VAL 142 142 142 VAL VAL A . n 
C 3 143 ASP 143 143 143 ASP ASP A . n 
C 3 144 TYR 144 144 144 TYR TYR A . n 
C 3 145 GLU 145 145 145 GLU GLU A . n 
C 3 146 VAL 146 146 146 VAL VAL A . n 
C 3 147 LYS 147 147 147 LYS LYS A . n 
C 3 148 ALA 148 148 148 ALA ALA A . n 
C 3 149 PHE 149 149 149 PHE PHE A . n 
C 3 150 CYS 150 150 150 CYS CYS A . n 
C 3 151 ALA 151 151 151 ALA ALA A . n 
C 3 152 GLU 152 152 152 GLU GLU A . n 
C 3 153 ASN 153 153 153 ASN ASN A . n 
C 3 154 LEU 154 154 154 LEU LEU A . n 
C 3 155 GLU 155 155 155 GLU GLU A . n 
C 3 156 GLU 156 156 156 GLU GLU A . n 
C 3 157 LYS 157 157 157 LYS LYS A . n 
C 3 158 ILE 158 158 158 ILE ILE A . n 
C 3 159 HIS 159 159 159 HIS HIS A . n 
C 3 160 LYS 160 160 160 LYS LYS A . n 
C 3 161 ARG 161 161 161 ARG ARG A . n 
C 3 162 ASN 162 162 162 ASN ASN A . n 
C 3 163 SER 163 163 163 SER SER A . n 
C 3 164 VAL 164 164 164 VAL VAL A . n 
C 3 165 ARG 165 165 165 ARG ARG A . n 
C 3 166 LEU 166 166 166 LEU LEU A . n 
C 3 167 VAL 167 167 167 VAL VAL A . n 
C 3 168 ILE 168 168 168 ILE ILE A . n 
C 3 169 ARG 169 169 169 ARG ARG A . n 
C 3 170 LYS 170 170 170 LYS LYS A . n 
C 3 171 VAL 171 171 171 VAL VAL A . n 
C 3 172 GLN 172 172 172 GLN GLN A . n 
C 3 173 TYR 173 173 173 TYR TYR A . n 
C 3 174 ALA 174 174 174 ALA ALA A . n 
C 3 175 PRO 175 175 175 PRO PRO A . n 
C 3 176 GLU 176 176 176 GLU GLU A . n 
C 3 177 ALA 177 177 177 ALA ALA A . n 
C 3 178 ASP 178 178 178 ASP ASP A . n 
C 3 179 LEU 179 179 179 LEU LEU A . n 
C 3 180 GLU 180 180 180 GLU GLU A . n 
C 3 181 ASP 181 181 181 ASP ASP A . n 
C 3 182 ASN 182 182 182 ASN ASN A . n 
C 3 183 TRP 183 183 183 TRP TRP A . n 
C 3 184 GLU 184 184 184 GLU GLU A . n 
C 3 185 THR 185 185 185 THR THR A . n 
C 3 186 LEU 186 186 186 LEU LEU A . n 
C 3 187 ASN 187 187 187 ASN ASN A . n 
C 3 188 ASP 188 188 188 ASP ASP A . n 
C 3 189 ASN 189 189 189 ASN ASN A . n 
C 3 190 LEU 190 190 190 LEU LEU A . n 
C 3 191 LYS 191 191 191 LYS LYS A . n 
C 3 192 VAL 192 192 192 VAL VAL A . n 
C 3 193 ILE 193 193 193 ILE ILE A . n 
C 3 194 GLU 194 194 194 GLU GLU A . n 
C 3 195 LYS 195 195 195 LYS LYS A . n 
C 3 196 ALA 196 196 196 ALA ALA A . n 
C 3 197 ASP 197 197 197 ASP ASP A . n 
C 3 198 ASN 198 198 198 ASN ASN A . n 
C 3 199 ALA 199 199 199 ALA ALA A . n 
C 3 200 ALA 200 200 200 ALA ALA A . n 
C 3 201 GLN 201 201 201 GLN GLN A . n 
C 3 202 VAL 202 202 202 VAL VAL A . n 
C 3 203 LYS 203 203 203 LYS LYS A . n 
C 3 204 ASP 204 204 204 ASP ASP A . n 
C 3 205 ALA 205 205 205 ALA ALA A . n 
C 3 206 LEU 206 206 206 LEU LEU A . n 
C 3 207 THR 207 207 207 THR THR A . n 
C 3 208 LYS 208 208 208 LYS LYS A . n 
C 3 209 MET 209 209 209 MET MET A . n 
C 3 210 ARG 210 210 210 ARG ARG A . n 
C 3 211 ALA 211 211 211 ALA ALA A . n 
C 3 212 ALA 212 212 212 ALA ALA A . n 
C 3 213 ALA 213 213 213 ALA ALA A . n 
C 3 214 LEU 214 214 214 LEU LEU A . n 
C 3 215 ASP 215 215 215 ASP ASP A . n 
C 3 216 ALA 216 216 216 ALA ALA A . n 
C 3 217 GLN 217 217 217 GLN GLN A . n 
C 3 218 LYS 218 218 218 LYS LYS A . n 
C 3 219 ALA 219 219 219 ALA ALA A . n 
C 3 220 THR 220 220 220 THR THR A . n 
C 3 221 PRO 221 221 221 PRO PRO A . n 
C 3 222 PRO 222 222 222 PRO PRO A . n 
C 3 223 LYS 223 223 223 LYS LYS A . n 
C 3 224 LEU 224 224 224 LEU LEU A . n 
C 3 225 GLU 225 225 225 GLU GLU A . n 
C 3 226 ASP 226 226 226 ASP ASP A . n 
C 3 227 LYS 227 227 227 LYS LYS A . n 
C 3 228 SER 228 228 228 SER SER A . n 
C 3 229 PRO 229 229 229 PRO PRO A . n 
C 3 230 ASP 230 230 230 ASP ASP A . n 
C 3 231 SER 231 231 231 SER SER A . n 
C 3 232 PRO 232 232 232 PRO PRO A . n 
C 3 233 GLU 233 233 233 GLU GLU A . n 
C 3 234 MET 234 234 234 MET MET A . n 
C 3 235 LYS 235 235 235 LYS LYS A . n 
C 3 236 ASP 236 236 236 ASP ASP A . n 
C 3 237 PHE 237 237 237 PHE PHE A . n 
C 3 238 ARG 238 238 238 ARG ARG A . n 
C 3 239 HIS 239 239 239 HIS HIS A . n 
C 3 240 GLY 240 240 240 GLY GLY A . n 
C 3 241 PHE 241 241 241 PHE PHE A . n 
C 3 242 ASP 242 242 242 ASP ASP A . n 
C 3 243 ILE 243 243 243 ILE ILE A . n 
C 3 244 LEU 244 244 244 LEU LEU A . n 
C 3 245 VAL 245 245 245 VAL VAL A . n 
C 3 246 GLY 246 246 246 GLY GLY A . n 
C 3 247 GLN 247 247 247 GLN GLN A . n 
C 3 248 ILE 248 248 248 ILE ILE A . n 
C 3 249 ASP 249 249 249 ASP ASP A . n 
C 3 250 ASP 250 250 250 ASP ASP A . n 
C 3 251 ALA 251 251 251 ALA ALA A . n 
C 3 252 LEU 252 252 252 LEU LEU A . n 
C 3 253 LYS 253 253 253 LYS LYS A . n 
C 3 254 LEU 254 254 254 LEU LEU A . n 
C 3 255 ALA 255 255 255 ALA ALA A . n 
C 3 256 ASN 256 256 256 ASN ASN A . n 
C 3 257 GLU 257 257 257 GLU GLU A . n 
C 3 258 GLY 258 258 258 GLY GLY A . n 
C 3 259 LYS 259 259 259 LYS LYS A . n 
C 3 260 VAL 260 260 260 VAL VAL A . n 
C 3 261 LYS 261 261 261 LYS LYS A . n 
C 3 262 GLU 262 262 262 GLU GLU A . n 
C 3 263 ALA 263 263 263 ALA ALA A . n 
C 3 264 GLN 264 264 264 GLN GLN A . n 
C 3 265 ALA 265 265 265 ALA ALA A . n 
C 3 266 ALA 266 266 266 ALA ALA A . n 
C 3 267 ALA 267 267 267 ALA ALA A . n 
C 3 268 GLU 268 268 268 GLU GLU A . n 
C 3 269 GLN 269 269 269 GLN GLN A . n 
C 3 270 LEU 270 270 270 LEU LEU A . n 
C 3 271 LYS 271 271 271 LYS LYS A . n 
C 3 272 THR 272 272 272 THR THR A . n 
C 3 273 THR 273 273 273 THR THR A . n 
C 3 274 ARG 274 274 274 ARG ARG A . n 
C 3 275 ASN 275 275 275 ASN ASN A . n 
C 3 276 ALA 276 276 276 ALA ALA A . n 
C 3 277 TYR 277 277 277 TYR TYR A . n 
C 3 278 ILE 278 278 278 ILE ILE A . n 
C 3 279 GLN 279 279 279 GLN GLN A . n 
C 3 280 LYS 280 280 280 LYS LYS A . n 
C 3 281 TYR 281 281 281 TYR TYR A . n 
C 3 282 LEU 282 282 282 LEU LEU A . n 
C 3 283 PRO 283 283 283 PRO PRO A . n 
C 3 284 THR 284 284 284 THR THR A . n 
C 3 285 ALA 285 285 285 ALA ALA A . n 
C 3 286 GLU 286 286 286 GLU GLU A . n 
C 3 287 THR 287 287 287 THR THR A . n 
C 3 288 THR 288 288 288 THR THR A . n 
C 3 289 ARG 289 289 289 ARG ARG A . n 
C 3 290 GLN 290 290 290 GLN GLN A . n 
C 3 291 PHE 291 291 291 PHE PHE A . n 
C 3 292 LEU 292 292 292 LEU LEU A . n 
C 3 293 MET 293 293 293 MET MET A . n 
C 3 294 SER 294 294 294 SER SER A . n 
C 3 295 ASP 295 295 295 ASP ASP A . n 
C 3 296 LYS 296 296 296 LYS LYS A . n 
C 3 297 PRO 297 297 297 PRO PRO A . n 
C 3 298 LEU 298 298 298 LEU LEU A . n 
C 3 299 HIS 299 299 299 HIS HIS A . n 
C 3 300 LEU 300 300 300 LEU LEU A . n 
C 3 301 GLU 301 301 301 GLU GLU A . n 
C 3 302 ALA 302 302 302 ALA ALA A . n 
C 3 303 SER 303 303 303 SER SER A . n 
C 3 304 LEU 304 304 304 LEU LEU A . n 
C 3 305 ASP 305 305 305 ASP ASP A . n 
C 3 306 LYS 306 306 306 LYS LYS A . n 
C 3 307 GLU 307 307 307 GLU GLU A . n 
C 3 308 ILE 308 308 308 ILE ILE A . n 
C 3 309 TYR 309 309 309 TYR TYR A . n 
C 3 310 TYR 310 310 310 TYR TYR A . n 
C 3 311 HIS 311 311 311 HIS HIS A . n 
C 3 312 GLY 312 312 312 GLY GLY A . n 
C 3 313 GLU 313 313 313 GLU GLU A . n 
C 3 314 PRO 314 314 314 PRO PRO A . n 
C 3 315 ILE 315 315 315 ILE ILE A . n 
C 3 316 SER 316 316 316 SER SER A . n 
C 3 317 VAL 317 317 317 VAL VAL A . n 
C 3 318 ASN 318 318 318 ASN ASN A . n 
C 3 319 VAL 319 319 319 VAL VAL A . n 
C 3 320 HIS 320 320 320 HIS HIS A . n 
C 3 321 VAL 321 321 321 VAL VAL A . n 
C 3 322 THR 322 322 322 THR THR A . n 
C 3 323 ASN 323 323 323 ASN ASN A . n 
C 3 324 ASN 324 324 324 ASN ASN A . n 
C 3 325 THR 325 325 325 THR THR A . n 
C 3 326 ASN 326 326 326 ASN ASN A . n 
C 3 327 LYS 327 327 327 LYS LYS A . n 
C 3 328 THR 328 328 328 THR THR A . n 
C 3 329 VAL 329 329 329 VAL VAL A . n 
C 3 330 LYS 330 330 330 LYS LYS A . n 
C 3 331 LYS 331 331 331 LYS LYS A . n 
C 3 332 ILE 332 332 332 ILE ILE A . n 
C 3 333 LYS 333 333 333 LYS LYS A . n 
C 3 334 ILE 334 334 334 ILE ILE A . n 
C 3 335 SER 335 335 335 SER SER A . n 
C 3 336 VAL 336 336 336 VAL VAL A . n 
C 3 337 ARG 337 337 337 ARG ARG A . n 
C 3 338 GLN 338 338 338 GLN GLN A . n 
C 3 339 TYR 339 339 339 TYR TYR A . n 
C 3 340 ALA 340 340 340 ALA ALA A . n 
C 3 341 ASP 341 341 341 ASP ASP A . n 
C 3 342 ILE 342 342 342 ILE ILE A . n 
C 3 343 CYS 343 343 343 CYS CYS A . n 
C 3 344 LEU 344 344 344 LEU LEU A . n 
C 3 345 PHE 345 345 345 PHE PHE A . n 
C 3 346 ASN 346 346 346 ASN ASN A . n 
C 3 347 THR 347 347 347 THR THR A . n 
C 3 348 ALA 348 348 348 ALA ALA A . n 
C 3 349 GLN 349 349 349 GLN GLN A . n 
C 3 350 TYR 350 350 350 TYR TYR A . n 
C 3 351 LYS 351 351 351 LYS LYS A . n 
C 3 352 CYS 352 352 352 CYS CYS A . n 
C 3 353 PRO 353 353 353 PRO PRO A . n 
C 3 354 VAL 354 354 354 VAL VAL A . n 
C 3 355 ALA 355 355 355 ALA ALA A . n 
C 3 356 MET 356 356 356 MET MET A . n 
C 3 357 GLU 357 357 357 GLU GLU A . n 
C 3 358 GLU 358 358 358 GLU GLU A . n 
C 3 359 ALA 359 359 359 ALA ALA A . n 
C 3 360 ASP 360 360 360 ASP ASP A . n 
C 3 361 ASP 361 361 361 ASP ASP A . n 
C 3 362 THR 362 362 362 THR THR A . n 
C 3 363 VAL 363 363 363 VAL VAL A . n 
C 3 364 ALA 364 364 364 ALA ALA A . n 
C 3 365 PRO 365 365 365 PRO PRO A . n 
C 3 366 SER 366 366 366 SER SER A . n 
C 3 367 SER 367 367 367 SER SER A . n 
C 3 368 THR 368 368 368 THR THR A . n 
C 3 369 PHE 369 369 369 PHE PHE A . n 
C 3 370 CYS 370 370 370 CYS CYS A . n 
C 3 371 LYS 371 371 371 LYS LYS A . n 
C 3 372 VAL 372 372 372 VAL VAL A . n 
C 3 373 TYR 373 373 373 TYR TYR A . n 
C 3 374 THR 374 374 374 THR THR A . n 
C 3 375 LEU 375 375 375 LEU LEU A . n 
C 3 376 THR 376 376 376 THR THR A . n 
C 3 377 PRO 377 377 377 PRO PRO A . n 
C 3 378 PHE 378 378 378 PHE PHE A . n 
C 3 379 LEU 379 379 379 LEU LEU A . n 
C 3 380 ALA 380 380 380 ALA ALA A . n 
C 3 381 ASN 381 381 381 ASN ASN A . n 
C 3 382 ASN 382 382 382 ASN ASN A . n 
C 3 383 ARG 383 383 383 ARG ARG A . n 
C 3 384 GLU 384 384 384 GLU GLU A . n 
C 3 385 LYS 385 385 385 LYS LYS A . n 
C 3 386 ARG 386 386 386 ARG ARG A . n 
C 3 387 GLY 387 387 387 GLY GLY A . n 
C 3 388 LEU 388 388 388 LEU LEU A . n 
C 3 389 ALA 389 389 389 ALA ALA A . n 
C 3 390 LEU 390 390 390 LEU LEU A . n 
C 3 391 ASP 391 391 391 ASP ASP A . n 
C 3 392 GLY 392 392 392 GLY GLY A . n 
C 3 393 LYS 393 393 ?   ?   ?   A . n 
C 3 394 LEU 394 394 ?   ?   ?   A . n 
C 3 395 LYS 395 395 ?   ?   ?   A . n 
C 3 396 HIS 396 396 ?   ?   ?   A . n 
C 3 397 GLU 397 397 ?   ?   ?   A . n 
C 3 398 ASP 398 398 398 ASP ASP A . n 
C 3 399 THR 399 399 399 THR THR A . n 
C 3 400 ASN 400 400 400 ASN ASN A . n 
C 3 401 LEU 401 401 401 LEU LEU A . n 
C 3 402 ALA 402 402 402 ALA ALA A . n 
C 3 403 SER 403 403 403 SER SER A . n 
C 3 404 SER 404 404 404 SER SER A . n 
C 3 405 THR 405 405 405 THR THR A . n 
C 3 406 LEU 406 406 406 LEU LEU A . n 
C 3 407 LEU 407 407 407 LEU LEU A . n 
C 3 408 ARG 408 408 408 ARG ARG A . n 
C 3 409 GLU 409 409 409 GLU GLU A . n 
C 3 410 GLY 410 410 410 GLY GLY A . n 
C 3 411 ALA 411 411 411 ALA ALA A . n 
C 3 412 ASN 412 412 412 ASN ASN A . n 
C 3 413 ARG 413 413 413 ARG ARG A . n 
C 3 414 GLU 414 414 414 GLU GLU A . n 
C 3 415 ILE 415 415 415 ILE ILE A . n 
C 3 416 LEU 416 416 416 LEU LEU A . n 
C 3 417 GLY 417 417 417 GLY GLY A . n 
C 3 418 ILE 418 418 418 ILE ILE A . n 
C 3 419 ILE 419 419 419 ILE ILE A . n 
C 3 420 VAL 420 420 420 VAL VAL A . n 
C 3 421 SER 421 421 421 SER SER A . n 
C 3 422 TYR 422 422 422 TYR TYR A . n 
C 3 423 LYS 423 423 423 LYS LYS A . n 
C 3 424 VAL 424 424 424 VAL VAL A . n 
C 3 425 LYS 425 425 425 LYS LYS A . n 
C 3 426 VAL 426 426 426 VAL VAL A . n 
C 3 427 LYS 427 427 427 LYS LYS A . n 
C 3 428 LEU 428 428 428 LEU LEU A . n 
C 3 429 VAL 429 429 429 VAL VAL A . n 
C 3 430 VAL 430 430 430 VAL VAL A . n 
C 3 431 SER 431 431 431 SER SER A . n 
C 3 432 ARG 432 432 432 ARG ARG A . n 
C 3 433 GLY 433 433 433 GLY GLY A . n 
C 3 434 ASP 434 434 ?   ?   ?   A . n 
C 3 435 TYR 435 435 ?   ?   ?   A . n 
C 3 436 LYS 436 436 ?   ?   ?   A . n 
C 3 437 ASP 437 437 ?   ?   ?   A . n 
C 3 438 ASP 438 438 ?   ?   ?   A . n 
C 3 439 ASP 439 439 ?   ?   ?   A . n 
C 3 440 ASP 440 440 ?   ?   ?   A . n 
C 3 441 LYS 441 441 ?   ?   ?   A . n 
C 3 442 SER 442 442 442 SER SER A . n 
C 3 443 ASP 443 443 443 ASP ASP A . n 
C 3 444 VAL 444 444 444 VAL VAL A . n 
C 3 445 ALA 445 445 445 ALA ALA A . n 
C 3 446 VAL 446 446 446 VAL VAL A . n 
C 3 447 GLU 447 447 447 GLU GLU A . n 
C 3 448 LEU 448 448 448 LEU LEU A . n 
C 3 449 PRO 449 449 449 PRO PRO A . n 
C 3 450 PHE 450 450 450 PHE PHE A . n 
C 3 451 THR 451 451 451 THR THR A . n 
C 3 452 LEU 452 452 452 LEU LEU A . n 
C 3 453 MET 453 453 453 MET MET A . n 
C 3 454 HIS 454 454 454 HIS HIS A . n 
C 3 455 PRO 455 455 455 PRO PRO A . n 
C 3 456 LYS 456 456 456 LYS LYS A . n 
C 3 457 PRO 457 457 457 PRO PRO A . n 
C 3 458 LYS 458 458 ?   ?   ?   A . n 
C 3 459 GLU 459 459 ?   ?   ?   A . n 
C 3 460 GLU 460 460 ?   ?   ?   A . n 
C 3 461 PRO 461 461 ?   ?   ?   A . n 
C 3 462 PRO 462 462 ?   ?   ?   A . n 
C 3 463 HIS 463 463 ?   ?   ?   A . n 
C 3 464 ARG 464 464 ?   ?   ?   A . n 
C 3 465 GLU 465 465 ?   ?   ?   A . n 
C 3 466 VAL 466 466 ?   ?   ?   A . n 
C 3 467 PRO 467 467 ?   ?   ?   A . n 
C 3 468 GLU 468 468 ?   ?   ?   A . n 
C 3 469 SER 469 469 ?   ?   ?   A . n 
C 3 470 GLU 470 470 ?   ?   ?   A . n 
C 3 471 THR 471 471 ?   ?   ?   A . n 
C 3 472 PRO 472 472 ?   ?   ?   A . n 
C 3 473 VAL 473 473 ?   ?   ?   A . n 
C 3 474 ASP 474 474 ?   ?   ?   A . n 
C 3 475 THR 475 475 ?   ?   ?   A . n 
C 3 476 ASN 476 476 ?   ?   ?   A . n 
C 3 477 LEU 477 477 ?   ?   ?   A . n 
C 3 478 ILE 478 478 ?   ?   ?   A . n 
C 3 479 GLU 479 479 ?   ?   ?   A . n 
C 3 480 LEU 480 480 ?   ?   ?   A . n 
C 3 481 ASP 481 481 ?   ?   ?   A . n 
C 3 482 THR 482 482 ?   ?   ?   A . n 
C 3 483 ASN 483 483 ?   ?   ?   A . n 
C 3 484 ASP 484 484 ?   ?   ?   A . n 
C 3 485 ASP 485 485 ?   ?   ?   A . n 
C 3 486 ASP 486 486 486 ASP ASP A . n 
C 3 487 ILE 487 487 487 ILE ILE A . n 
C 3 488 VAL 488 488 488 VAL VAL A . n 
C 3 489 PHE 489 489 489 PHE PHE A . n 
C 3 490 GLU 490 490 490 GLU GLU A . n 
C 3 491 ASP 491 491 491 ASP ASP A . n 
C 3 492 PHE 492 492 492 PHE PHE A . n 
C 3 493 ALA 493 493 ?   ?   ?   A . n 
C 3 494 ARG 494 494 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ODN 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ODN 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         D 
_pdbx_nonpoly_scheme.entity_id       4 
_pdbx_nonpoly_scheme.mon_id          ODN 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      ODN 
_pdbx_nonpoly_scheme.auth_mon_id     ODN 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASP 93  ? CG  ? C ASP 93  CG  
2  1 Y 1 A ASP 93  ? OD1 ? C ASP 93  OD1 
3  1 Y 1 A ASP 93  ? OD2 ? C ASP 93  OD2 
4  1 Y 1 A ARG 99  ? CG  ? C ARG 99  CG  
5  1 Y 1 A ARG 99  ? CD  ? C ARG 99  CD  
6  1 Y 1 A ARG 99  ? NE  ? C ARG 99  NE  
7  1 Y 1 A ARG 99  ? CZ  ? C ARG 99  CZ  
8  1 Y 1 A ARG 99  ? NH1 ? C ARG 99  NH1 
9  1 Y 1 A ARG 99  ? NH2 ? C ARG 99  NH2 
10 1 Y 1 A LYS 106 ? CG  ? C LYS 106 CG  
11 1 Y 1 A LYS 106 ? CD  ? C LYS 106 CD  
12 1 Y 1 A LYS 106 ? CE  ? C LYS 106 CE  
13 1 Y 1 A LYS 106 ? NZ  ? C LYS 106 NZ  
14 1 Y 1 A GLU 155 ? CG  ? C GLU 155 CG  
15 1 Y 1 A GLU 155 ? CD  ? C GLU 155 CD  
16 1 Y 1 A GLU 155 ? OE1 ? C GLU 155 OE1 
17 1 Y 1 A GLU 155 ? OE2 ? C GLU 155 OE2 
18 1 Y 1 A LYS 157 ? CG  ? C LYS 157 CG  
19 1 Y 1 A LYS 157 ? CD  ? C LYS 157 CD  
20 1 Y 1 A LYS 157 ? CE  ? C LYS 157 CE  
21 1 Y 1 A LYS 157 ? NZ  ? C LYS 157 NZ  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DNM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DNM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DNM 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9DNM 
_struct.title                        'Structure of rat beta-arrestin 1 bound to allosteric inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DNM 
_struct_keywords.text            'GPCR signaling, arrestin, allostery, SIGNALING PROTEIN, SIGNALING PROTEIN-Immune System complex' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN/Immune System' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9DNM       9DNM   ? 1 ? 1   
2 PDB 9DNM       9DNM   ? 2 ? 1   
3 UNP ARRB1_RAT  P29066 ? 3 
;GDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFV
ANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKR
NSVRLVIRKVQYAPE
;
2   
4 UNP C562_ECOLX P0ABE7 ? 3 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKYR
;
23  
5 UNP ARRB1_RAT  P29066 ? 3 
;PTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDT
VAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASS
DVAVELPFTLMHPKPKEEPPHREVPESETPVDTNLIELDTNDDDIVFEDFAR
;
182 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DNM H 1   ? 225 ? 9DNM   4   ? 228 ? 4   228 
2 2 9DNM L 1   ? 212 ? 9DNM   2   ? 213 ? 2   213 
3 3 9DNM A 2   ? 176 ? P29066 2   ? 176 ? 2   176 
4 4 9DNM A 177 ? 282 ? P0ABE7 23  ? 128 ? 177 282 
5 5 9DNM A 283 ? 494 ? P29066 182 ? 393 ? 283 494 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
3 9DNM LEU A 1   ? UNP P29066 ?   ?   'expression tag'      1   1  
4 9DNM TRP A 183 ? UNP P0ABE7 MET 29  'engineered mutation' 183 2  
4 9DNM ILE A 278 ? UNP P0ABE7 HIS 124 'engineered mutation' 278 3  
4 9DNM LEU A 282 ? UNP P0ABE7 ARG 128 'engineered mutation' 282 4  
5 9DNM ASP A 434 ? UNP P29066 GLY 333 'engineered mutation' 434 5  
5 9DNM TYR A 435 ? UNP P29066 LEU 334 'engineered mutation' 435 6  
5 9DNM LYS A 436 ? UNP P29066 LEU 335 'engineered mutation' 436 7  
5 9DNM ASP A 437 ? UNP P29066 GLY 336 'engineered mutation' 437 8  
5 9DNM ASP A 439 ? UNP P29066 LEU 338 'engineered mutation' 439 9  
5 9DNM ASP A 440 ? UNP P29066 ALA 339 'engineered mutation' 440 10 
5 9DNM LYS A 441 ? UNP P29066 SER 340 'engineered mutation' 441 11 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 28  ? PHE A 32  ? ASN H 31  PHE H 35  5 ? 5  
HELX_P HELX_P2  AA2 GLN B 79  ? PHE B 83  ? GLN L 80  PHE L 84  5 ? 5  
HELX_P HELX_P3  AA3 THR C 98  ? LEU C 108 ? THR A 98  LEU A 108 1 ? 11 
HELX_P HELX_P4  AA4 HIS C 159 ? ARG C 161 ? HIS A 159 ARG A 161 5 ? 3  
HELX_P HELX_P5  AA5 ALA C 177 ? LYS C 195 ? ALA A 177 LYS A 195 1 ? 19 
HELX_P HELX_P6  AA6 ASN C 198 ? ALA C 219 ? ASN A 198 ALA A 219 1 ? 22 
HELX_P HELX_P7  AA7 PRO C 221 ? GLU C 225 ? PRO A 221 GLU A 225 5 ? 5  
HELX_P HELX_P8  AA8 SER C 231 ? GLY C 258 ? SER A 231 GLY A 258 1 ? 28 
HELX_P HELX_P9  AA9 LYS C 259 ? GLU C 268 ? LYS A 259 GLU A 268 1 ? 10 
HELX_P HELX_P10 AB1 GLN C 269 ? LEU C 282 ? GLN A 269 LEU A 282 1 ? 14 
HELX_P HELX_P11 AB2 PHE C 378 ? ARG C 383 ? PHE A 378 ARG A 383 5 ? 6  
HELX_P HELX_P12 AB3 ASN C 412 ? LEU C 416 ? ASN A 412 LEU A 416 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 22 SG ? ? ? 1_555 A CYS 96 SG ? ? H CYS 25 H CYS 99 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2 disulf ? ? B CYS 23 SG ? ? ? 1_555 B CYS 88 SG ? ? L CYS 24 L CYS 89 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 22 ? CYS A 96 ? CYS H 25 ? 1_555 CYS H 99 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 23 ? CYS B 88 ? CYS L 24 ? 1_555 CYS L 89 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           87 
_struct_mon_prot_cis.label_asym_id          C 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            87 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    88 
_struct_mon_prot_cis.pdbx_label_asym_id_2   C 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     88 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -5.93 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 6 ? 
AA5 ? 4 ? 
AA6 ? 5 ? 
AA7 ? 4 ? 
AA8 ? 2 ? 
AA9 ? 4 ? 
AB1 ? 2 ? 
AB2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? parallel      
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? parallel      
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 3   ? SER A 7   ? GLN H 6   SER H 10  
AA1 2 LEU A 18  ? SER A 25  ? LEU H 21  SER H 28  
AA1 3 THR A 78  ? MET A 83  ? THR H 81  MET H 86  
AA1 4 THR A 69  ? ASP A 73  ? THR H 72  ASP H 76  
AA2 1 LEU A 11  ? VAL A 12  ? LEU H 14  VAL H 15  
AA2 2 THR A 118 ? VAL A 122 ? THR H 121 VAL H 125 
AA2 3 ALA A 92  ? TRP A 99  ? ALA H 95  TRP H 102 
AA2 4 SER A 33  ? GLN A 39  ? SER H 36  GLN H 42  
AA2 5 LEU A 45  ? ILE A 51  ? LEU H 48  ILE H 54  
AA2 6 THR A 58  ? TYR A 60  ? THR H 61  TYR H 63  
AA3 1 MET B 4   ? GLN B 6   ? MET L 5   GLN L 7   
AA3 2 VAL B 19  ? ALA B 25  ? VAL L 20  ALA L 26  
AA3 3 ASP B 70  ? ILE B 75  ? ASP L 71  ILE L 76  
AA3 4 PHE B 62  ? ARG B 66  ? PHE L 63  ARG L 67  
AA4 1 SER B 10  ? SER B 12  ? SER L 11  SER L 13  
AA4 2 THR B 103 ? GLU B 106 ? THR L 104 GLU L 107 
AA4 3 THR B 85  ? GLN B 90  ? THR L 86  GLN L 91  
AA4 4 VAL B 33  ? GLN B 38  ? VAL L 34  GLN L 39  
AA4 5 LYS B 45  ? TYR B 49  ? LYS L 46  TYR L 50  
AA4 6 SER B 53  ? LEU B 54  ? SER L 54  LEU L 55  
AA5 1 SER B 10  ? SER B 12  ? SER L 11  SER L 13  
AA5 2 THR B 103 ? GLU B 106 ? THR L 104 GLU L 107 
AA5 3 THR B 85  ? GLN B 90  ? THR L 86  GLN L 91  
AA5 4 THR B 98  ? PHE B 99  ? THR L 99  PHE L 100 
AA6 1 ALA C 112 ? PRO C 114 ? ALA A 112 PRO A 114 
AA6 2 VAL C 40  ? VAL C 43  ? VAL A 40  VAL A 43  
AA6 3 LEU C 18  ? LEU C 22  ? LEU A 18  LEU A 22  
AA6 4 ARG C 7   ? LYS C 11  ? ARG A 7   LYS A 11  
AA6 5 VAL C 488 ? ASP C 491 ? VAL A 488 ASP A 491 
AA7 1 LYS C 77  ? GLN C 85  ? LYS A 77  GLN A 85  
AA7 2 ARG C 52  ? PHE C 61  ? ARG A 52  PHE A 61  
AA7 3 VAL C 142 ? ALA C 151 ? VAL A 142 ALA A 151 
AA7 4 SER C 163 ? ILE C 168 ? SER A 163 ILE A 168 
AA8 1 SER C 126 ? VAL C 127 ? SER A 126 VAL A 127 
AA8 2 ALA C 389 ? LEU C 390 ? ALA A 389 LEU A 390 
AA9 1 THR C 284 ? ARG C 289 ? THR A 284 ARG A 289 
AA9 2 LEU C 298 ? LEU C 304 ? LEU A 298 LEU A 304 
AA9 3 ILE C 315 ? THR C 322 ? ILE A 315 THR A 322 
AA9 4 THR C 368 ? LEU C 375 ? THR A 368 LEU A 375 
AB1 1 ILE C 308 ? TYR C 310 ? ILE A 308 TYR A 310 
AB1 2 THR C 451 ? MET C 453 ? THR A 451 MET A 453 
AB2 1 LYS C 351 ? GLU C 357 ? LYS A 351 GLU A 357 
AB2 2 VAL C 329 ? CYS C 343 ? VAL A 329 CYS A 343 
AB2 3 GLY C 417 ? VAL C 430 ? GLY A 417 VAL A 430 
AB2 4 VAL C 444 ? GLU C 447 ? VAL A 444 GLU A 447 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 5   ? N VAL H 8   O ALA A 23  ? O ALA H 26  
AA1 2 3 N LEU A 20  ? N LEU H 23  O LEU A 81  ? O LEU H 84  
AA1 3 4 O TYR A 80  ? O TYR H 83  N SER A 71  ? N SER H 74  
AA2 1 2 N VAL A 12  ? N VAL H 15  O THR A 121 ? O THR H 124 
AA2 2 3 O THR A 118 ? O THR H 121 N TYR A 94  ? N TYR H 97  
AA2 3 4 O TYR A 95  ? O TYR H 98  N VAL A 37  ? N VAL H 40  
AA2 4 5 N TRP A 36  ? N TRP H 39  O VAL A 48  ? O VAL H 51  
AA2 5 6 N TYR A 50  ? N TYR H 53  O SER A 59  ? O SER H 62  
AA3 1 2 N THR B 5   ? N THR L 6   O ARG B 24  ? O ARG L 25  
AA3 2 3 N CYS B 23  ? N CYS L 24  O PHE B 71  ? O PHE L 72  
AA3 3 4 O THR B 74  ? O THR L 75  N SER B 63  ? N SER L 64  
AA4 1 2 N LEU B 11  ? N LEU L 12  O LYS B 104 ? O LYS L 105 
AA4 2 3 O THR B 103 ? O THR L 104 N TYR B 86  ? N TYR L 87  
AA4 3 4 O THR B 85  ? O THR L 86  N GLN B 38  ? N GLN L 39  
AA4 4 5 N TRP B 35  ? N TRP L 36  O LEU B 47  ? O LEU L 48  
AA4 5 6 N TYR B 49  ? N TYR L 50  O SER B 53  ? O SER L 54  
AA5 1 2 N LEU B 11  ? N LEU L 12  O LYS B 104 ? O LYS L 105 
AA5 2 3 O THR B 103 ? O THR L 104 N TYR B 86  ? N TYR L 87  
AA5 3 4 N GLN B 90  ? N GLN L 91  O THR B 98  ? O THR L 99  
AA6 1 2 O TYR C 113 ? O TYR A 113 N VAL C 41  ? N VAL A 41  
AA6 2 3 O VAL C 40  ? O VAL A 40  N TYR C 21  ? N TYR A 21  
AA6 3 4 O LEU C 22  ? O LEU A 22  N PHE C 9   ? N PHE A 9   
AA6 4 5 N VAL C 8   ? N VAL A 8   O GLU C 490 ? O GLU A 490 
AA7 1 2 O LYS C 77  ? O LYS A 77  N PHE C 61  ? N PHE A 61  
AA7 2 3 N THR C 56  ? N THR A 56  O LYS C 147 ? O LYS A 147 
AA7 3 4 N VAL C 146 ? N VAL A 146 O LEU C 166 ? O LEU A 166 
AA8 1 2 N SER C 126 ? N SER A 126 O LEU C 390 ? O LEU A 390 
AA9 1 2 N ARG C 289 ? N ARG A 289 O LEU C 298 ? O LEU A 298 
AA9 2 3 N SER C 303 ? N SER A 303 O ASN C 318 ? O ASN A 318 
AA9 3 4 N VAL C 317 ? N VAL A 317 O TYR C 373 ? O TYR A 373 
AB1 1 2 N TYR C 309 ? N TYR A 309 O THR C 451 ? O THR A 451 
AB2 1 2 O GLU C 357 ? O GLU A 357 N ILE C 334 ? N ILE A 334 
AB2 2 3 N TYR C 339 ? N TYR A 339 O SER C 421 ? O SER A 421 
AB2 3 4 N LEU C 428 ? N LEU A 428 O VAL C 444 ? O VAL A 444 
# 
_pdbx_entry_details.entry_id                   9DNM 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 VAL H 51  ? ? -101.90 -63.95  
2  1 SER H 56  ? ? 68.87   -3.61   
3  1 ALA H 91  ? ? 69.78   -3.36   
4  1 ALA L 33  ? ? -96.96  56.93   
5  1 ALA L 52  ? ? 68.59   -5.84   
6  1 ILE A 31  ? ? 64.33   -65.36  
7  1 LEU A 48  ? ? -87.55  35.26   
8  1 ALA A 151 ? ? -172.04 -178.92 
9  1 ASN A 198 ? ? -125.42 -169.63 
10 1 THR A 347 ? ? 37.28   47.64   
11 1 VAL A 354 ? ? -124.48 -51.66  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9DNM 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
loop_
_em_3d_fitting_list.id 
_em_3d_fitting_list.3d_fitting_id 
_em_3d_fitting_list.pdb_entry_id 
_em_3d_fitting_list.pdb_chain_id 
_em_3d_fitting_list.pdb_chain_residue_range 
_em_3d_fitting_list.details 
_em_3d_fitting_list.chain_id 
_em_3d_fitting_list.chain_residue_range 
_em_3d_fitting_list.source_name 
_em_3d_fitting_list.type 
_em_3d_fitting_list.accession_code 
_em_3d_fitting_list.initial_refinement_model_id 
1 1 1G4M A ? ?                                A ? PDB 'experimental model' 1G4M 1 
2 1 6WW2 L ? ?                                L ? PDB 'experimental model' 6WW2 2 
3 1 6WW2 H ? ?                                H ? PDB 'experimental model' 6WW2 2 
4 1 6WW2 A ? 'soluble cytochrome b562 insert' A ? PDB 'experimental model' 6WW2 2 
# 
_em_3d_reconstruction.entry_id                    9DNM 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.47 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               177430 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-BRIL Fab' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_imaging.entry_id                        9DNM 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2400 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9DNM 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9DNM 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 H SER 129 ? A SER 126 
2   1 Y 1 H THR 130 ? A THR 127 
3   1 Y 1 H LYS 131 ? A LYS 128 
4   1 Y 1 H GLY 132 ? A GLY 129 
5   1 Y 1 H PRO 133 ? A PRO 130 
6   1 Y 1 H SER 134 ? A SER 131 
7   1 Y 1 H VAL 135 ? A VAL 132 
8   1 Y 1 H PHE 136 ? A PHE 133 
9   1 Y 1 H PRO 137 ? A PRO 134 
10  1 Y 1 H LEU 138 ? A LEU 135 
11  1 Y 1 H ALA 139 ? A ALA 136 
12  1 Y 1 H PRO 140 ? A PRO 137 
13  1 Y 1 H SER 141 ? A SER 138 
14  1 Y 1 H SER 142 ? A SER 139 
15  1 Y 1 H LYS 143 ? A LYS 140 
16  1 Y 1 H SER 144 ? A SER 141 
17  1 Y 1 H THR 145 ? A THR 142 
18  1 Y 1 H SER 146 ? A SER 143 
19  1 Y 1 H GLY 147 ? A GLY 144 
20  1 Y 1 H GLY 148 ? A GLY 145 
21  1 Y 1 H THR 149 ? A THR 146 
22  1 Y 1 H ALA 150 ? A ALA 147 
23  1 Y 1 H ALA 151 ? A ALA 148 
24  1 Y 1 H LEU 152 ? A LEU 149 
25  1 Y 1 H GLY 153 ? A GLY 150 
26  1 Y 1 H CYS 154 ? A CYS 151 
27  1 Y 1 H LEU 155 ? A LEU 152 
28  1 Y 1 H VAL 156 ? A VAL 153 
29  1 Y 1 H LYS 157 ? A LYS 154 
30  1 Y 1 H ASP 158 ? A ASP 155 
31  1 Y 1 H TYR 159 ? A TYR 156 
32  1 Y 1 H PHE 160 ? A PHE 157 
33  1 Y 1 H PRO 161 ? A PRO 158 
34  1 Y 1 H GLU 162 ? A GLU 159 
35  1 Y 1 H PRO 163 ? A PRO 160 
36  1 Y 1 H VAL 164 ? A VAL 161 
37  1 Y 1 H THR 165 ? A THR 162 
38  1 Y 1 H VAL 166 ? A VAL 163 
39  1 Y 1 H SER 167 ? A SER 164 
40  1 Y 1 H TRP 168 ? A TRP 165 
41  1 Y 1 H ASN 169 ? A ASN 166 
42  1 Y 1 H SER 170 ? A SER 167 
43  1 Y 1 H GLY 171 ? A GLY 168 
44  1 Y 1 H ALA 172 ? A ALA 169 
45  1 Y 1 H LEU 173 ? A LEU 170 
46  1 Y 1 H THR 174 ? A THR 171 
47  1 Y 1 H SER 175 ? A SER 172 
48  1 Y 1 H GLY 176 ? A GLY 173 
49  1 Y 1 H VAL 177 ? A VAL 174 
50  1 Y 1 H HIS 178 ? A HIS 175 
51  1 Y 1 H THR 179 ? A THR 176 
52  1 Y 1 H PHE 180 ? A PHE 177 
53  1 Y 1 H PRO 181 ? A PRO 178 
54  1 Y 1 H ALA 182 ? A ALA 179 
55  1 Y 1 H VAL 183 ? A VAL 180 
56  1 Y 1 H LEU 184 ? A LEU 181 
57  1 Y 1 H GLN 185 ? A GLN 182 
58  1 Y 1 H SER 186 ? A SER 183 
59  1 Y 1 H SER 187 ? A SER 184 
60  1 Y 1 H GLY 188 ? A GLY 185 
61  1 Y 1 H LEU 189 ? A LEU 186 
62  1 Y 1 H TYR 190 ? A TYR 187 
63  1 Y 1 H SER 191 ? A SER 188 
64  1 Y 1 H LEU 192 ? A LEU 189 
65  1 Y 1 H SER 193 ? A SER 190 
66  1 Y 1 H SER 194 ? A SER 191 
67  1 Y 1 H VAL 195 ? A VAL 192 
68  1 Y 1 H VAL 196 ? A VAL 193 
69  1 Y 1 H THR 197 ? A THR 194 
70  1 Y 1 H VAL 198 ? A VAL 195 
71  1 Y 1 H PRO 199 ? A PRO 196 
72  1 Y 1 H SER 200 ? A SER 197 
73  1 Y 1 H SER 201 ? A SER 198 
74  1 Y 1 H SER 202 ? A SER 199 
75  1 Y 1 H LEU 203 ? A LEU 200 
76  1 Y 1 H GLY 204 ? A GLY 201 
77  1 Y 1 H THR 205 ? A THR 202 
78  1 Y 1 H GLN 206 ? A GLN 203 
79  1 Y 1 H THR 207 ? A THR 204 
80  1 Y 1 H TYR 208 ? A TYR 205 
81  1 Y 1 H ILE 209 ? A ILE 206 
82  1 Y 1 H CYS 210 ? A CYS 207 
83  1 Y 1 H ASN 211 ? A ASN 208 
84  1 Y 1 H VAL 212 ? A VAL 209 
85  1 Y 1 H ASN 213 ? A ASN 210 
86  1 Y 1 H HIS 214 ? A HIS 211 
87  1 Y 1 H LYS 215 ? A LYS 212 
88  1 Y 1 H PRO 216 ? A PRO 213 
89  1 Y 1 H SER 217 ? A SER 214 
90  1 Y 1 H ASN 218 ? A ASN 215 
91  1 Y 1 H THR 219 ? A THR 216 
92  1 Y 1 H LYS 220 ? A LYS 217 
93  1 Y 1 H VAL 221 ? A VAL 218 
94  1 Y 1 H ASP 222 ? A ASP 219 
95  1 Y 1 H LYS 223 ? A LYS 220 
96  1 Y 1 H LYS 224 ? A LYS 221 
97  1 Y 1 H VAL 225 ? A VAL 222 
98  1 Y 1 H GLU 226 ? A GLU 223 
99  1 Y 1 H PRO 227 ? A PRO 224 
100 1 Y 1 H LYS 228 ? A LYS 225 
101 1 Y 1 L ARG 110 ? B ARG 109 
102 1 Y 1 L THR 111 ? B THR 110 
103 1 Y 1 L VAL 112 ? B VAL 111 
104 1 Y 1 L ALA 113 ? B ALA 112 
105 1 Y 1 L ALA 114 ? B ALA 113 
106 1 Y 1 L PRO 115 ? B PRO 114 
107 1 Y 1 L SER 116 ? B SER 115 
108 1 Y 1 L VAL 117 ? B VAL 116 
109 1 Y 1 L PHE 118 ? B PHE 117 
110 1 Y 1 L ILE 119 ? B ILE 118 
111 1 Y 1 L PHE 120 ? B PHE 119 
112 1 Y 1 L PRO 121 ? B PRO 120 
113 1 Y 1 L PRO 122 ? B PRO 121 
114 1 Y 1 L SER 123 ? B SER 122 
115 1 Y 1 L ASP 124 ? B ASP 123 
116 1 Y 1 L SER 125 ? B SER 124 
117 1 Y 1 L GLN 126 ? B GLN 125 
118 1 Y 1 L LEU 127 ? B LEU 126 
119 1 Y 1 L LYS 128 ? B LYS 127 
120 1 Y 1 L SER 129 ? B SER 128 
121 1 Y 1 L GLY 130 ? B GLY 129 
122 1 Y 1 L THR 131 ? B THR 130 
123 1 Y 1 L ALA 132 ? B ALA 131 
124 1 Y 1 L SER 133 ? B SER 132 
125 1 Y 1 L VAL 134 ? B VAL 133 
126 1 Y 1 L VAL 135 ? B VAL 134 
127 1 Y 1 L CYS 136 ? B CYS 135 
128 1 Y 1 L LEU 137 ? B LEU 136 
129 1 Y 1 L LEU 138 ? B LEU 137 
130 1 Y 1 L ASN 139 ? B ASN 138 
131 1 Y 1 L ASN 140 ? B ASN 139 
132 1 Y 1 L PHE 141 ? B PHE 140 
133 1 Y 1 L TYR 142 ? B TYR 141 
134 1 Y 1 L PRO 143 ? B PRO 142 
135 1 Y 1 L ARG 144 ? B ARG 143 
136 1 Y 1 L GLU 145 ? B GLU 144 
137 1 Y 1 L ALA 146 ? B ALA 145 
138 1 Y 1 L LYS 147 ? B LYS 146 
139 1 Y 1 L VAL 148 ? B VAL 147 
140 1 Y 1 L GLN 149 ? B GLN 148 
141 1 Y 1 L TRP 150 ? B TRP 149 
142 1 Y 1 L LYS 151 ? B LYS 150 
143 1 Y 1 L VAL 152 ? B VAL 151 
144 1 Y 1 L ASP 153 ? B ASP 152 
145 1 Y 1 L ASN 154 ? B ASN 153 
146 1 Y 1 L ALA 155 ? B ALA 154 
147 1 Y 1 L LEU 156 ? B LEU 155 
148 1 Y 1 L GLN 157 ? B GLN 156 
149 1 Y 1 L SER 158 ? B SER 157 
150 1 Y 1 L GLY 159 ? B GLY 158 
151 1 Y 1 L ASN 160 ? B ASN 159 
152 1 Y 1 L SER 161 ? B SER 160 
153 1 Y 1 L GLN 162 ? B GLN 161 
154 1 Y 1 L GLU 163 ? B GLU 162 
155 1 Y 1 L SER 164 ? B SER 163 
156 1 Y 1 L VAL 165 ? B VAL 164 
157 1 Y 1 L THR 166 ? B THR 165 
158 1 Y 1 L GLU 167 ? B GLU 166 
159 1 Y 1 L GLN 168 ? B GLN 167 
160 1 Y 1 L ASP 169 ? B ASP 168 
161 1 Y 1 L SER 170 ? B SER 169 
162 1 Y 1 L LYS 171 ? B LYS 170 
163 1 Y 1 L ASP 172 ? B ASP 171 
164 1 Y 1 L SER 173 ? B SER 172 
165 1 Y 1 L THR 174 ? B THR 173 
166 1 Y 1 L TYR 175 ? B TYR 174 
167 1 Y 1 L SER 176 ? B SER 175 
168 1 Y 1 L LEU 177 ? B LEU 176 
169 1 Y 1 L SER 178 ? B SER 177 
170 1 Y 1 L SER 179 ? B SER 178 
171 1 Y 1 L THR 180 ? B THR 179 
172 1 Y 1 L LEU 181 ? B LEU 180 
173 1 Y 1 L THR 182 ? B THR 181 
174 1 Y 1 L LEU 183 ? B LEU 182 
175 1 Y 1 L SER 184 ? B SER 183 
176 1 Y 1 L LYS 185 ? B LYS 184 
177 1 Y 1 L ALA 186 ? B ALA 185 
178 1 Y 1 L ASP 187 ? B ASP 186 
179 1 Y 1 L TYR 188 ? B TYR 187 
180 1 Y 1 L GLU 189 ? B GLU 188 
181 1 Y 1 L LYS 190 ? B LYS 189 
182 1 Y 1 L HIS 191 ? B HIS 190 
183 1 Y 1 L LYS 192 ? B LYS 191 
184 1 Y 1 L VAL 193 ? B VAL 192 
185 1 Y 1 L TYR 194 ? B TYR 193 
186 1 Y 1 L ALA 195 ? B ALA 194 
187 1 Y 1 L CYS 196 ? B CYS 195 
188 1 Y 1 L GLU 197 ? B GLU 196 
189 1 Y 1 L VAL 198 ? B VAL 197 
190 1 Y 1 L THR 199 ? B THR 198 
191 1 Y 1 L HIS 200 ? B HIS 199 
192 1 Y 1 L GLN 201 ? B GLN 200 
193 1 Y 1 L GLY 202 ? B GLY 201 
194 1 Y 1 L LEU 203 ? B LEU 202 
195 1 Y 1 L SER 204 ? B SER 203 
196 1 Y 1 L SER 205 ? B SER 204 
197 1 Y 1 L PRO 206 ? B PRO 205 
198 1 Y 1 L VAL 207 ? B VAL 206 
199 1 Y 1 L THR 208 ? B THR 207 
200 1 Y 1 L LYS 209 ? B LYS 208 
201 1 Y 1 L SER 210 ? B SER 209 
202 1 Y 1 L PHE 211 ? B PHE 210 
203 1 Y 1 L ASN 212 ? B ASN 211 
204 1 Y 1 L ARG 213 ? B ARG 212 
205 1 Y 1 A LEU 1   ? C LEU 1   
206 1 Y 1 A GLY 2   ? C GLY 2   
207 1 Y 1 A ASP 3   ? C ASP 3   
208 1 Y 1 A LYS 4   ? C LYS 4   
209 1 Y 1 A GLY 5   ? C GLY 5   
210 1 Y 1 A TYR 63  ? C TYR 63  
211 1 Y 1 A GLY 64  ? C GLY 64  
212 1 Y 1 A ARG 65  ? C ARG 65  
213 1 Y 1 A GLU 66  ? C GLU 66  
214 1 Y 1 A ASP 67  ? C ASP 67  
215 1 Y 1 A LEU 68  ? C LEU 68  
216 1 Y 1 A ASP 69  ? C ASP 69  
217 1 Y 1 A VAL 70  ? C VAL 70  
218 1 Y 1 A LEU 71  ? C LEU 71  
219 1 Y 1 A GLY 72  ? C GLY 72  
220 1 Y 1 A LEU 73  ? C LEU 73  
221 1 Y 1 A LYS 393 ? C LYS 393 
222 1 Y 1 A LEU 394 ? C LEU 394 
223 1 Y 1 A LYS 395 ? C LYS 395 
224 1 Y 1 A HIS 396 ? C HIS 396 
225 1 Y 1 A GLU 397 ? C GLU 397 
226 1 Y 1 A ASP 434 ? C ASP 434 
227 1 Y 1 A TYR 435 ? C TYR 435 
228 1 Y 1 A LYS 436 ? C LYS 436 
229 1 Y 1 A ASP 437 ? C ASP 437 
230 1 Y 1 A ASP 438 ? C ASP 438 
231 1 Y 1 A ASP 439 ? C ASP 439 
232 1 Y 1 A ASP 440 ? C ASP 440 
233 1 Y 1 A LYS 441 ? C LYS 441 
234 1 Y 1 A LYS 458 ? C LYS 458 
235 1 Y 1 A GLU 459 ? C GLU 459 
236 1 Y 1 A GLU 460 ? C GLU 460 
237 1 Y 1 A PRO 461 ? C PRO 461 
238 1 Y 1 A PRO 462 ? C PRO 462 
239 1 Y 1 A HIS 463 ? C HIS 463 
240 1 Y 1 A ARG 464 ? C ARG 464 
241 1 Y 1 A GLU 465 ? C GLU 465 
242 1 Y 1 A VAL 466 ? C VAL 466 
243 1 Y 1 A PRO 467 ? C PRO 467 
244 1 Y 1 A GLU 468 ? C GLU 468 
245 1 Y 1 A SER 469 ? C SER 469 
246 1 Y 1 A GLU 470 ? C GLU 470 
247 1 Y 1 A THR 471 ? C THR 471 
248 1 Y 1 A PRO 472 ? C PRO 472 
249 1 Y 1 A VAL 473 ? C VAL 473 
250 1 Y 1 A ASP 474 ? C ASP 474 
251 1 Y 1 A THR 475 ? C THR 475 
252 1 Y 1 A ASN 476 ? C ASN 476 
253 1 Y 1 A LEU 477 ? C LEU 477 
254 1 Y 1 A ILE 478 ? C ILE 478 
255 1 Y 1 A GLU 479 ? C GLU 479 
256 1 Y 1 A LEU 480 ? C LEU 480 
257 1 Y 1 A ASP 481 ? C ASP 481 
258 1 Y 1 A THR 482 ? C THR 482 
259 1 Y 1 A ASN 483 ? C ASN 483 
260 1 Y 1 A ASP 484 ? C ASP 484 
261 1 Y 1 A ASP 485 ? C ASP 485 
262 1 Y 1 A ALA 493 ? C ALA 493 
263 1 Y 1 A ARG 494 ? C ARG 494 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
ODN O3   O N N 247 
ODN C17  C N N 248 
ODN C10  C N R 249 
ODN C18  C N S 250 
ODN O4   O N N 251 
ODN O1   O N N 252 
ODN C8   C N N 253 
ODN C19  C N S 254 
ODN O5   O N N 255 
ODN C6   C N R 256 
ODN C3   C N N 257 
ODN C5   C N N 258 
ODN C4   C N N 259 
ODN C2   C N N 260 
ODN C1   C N N 261 
ODN C13  C N R 262 
ODN C14  C N N 263 
ODN C12  C N S 264 
ODN C11  C N R 265 
ODN O2   O N N 266 
ODN C15  C N N 267 
ODN C16  C N N 268 
ODN C9   C N S 269 
ODN C7   C N S 270 
ODN C    C N S 271 
ODN O    O N N 272 
ODN H1   H N N 273 
ODN H2   H N N 274 
ODN H3   H N N 275 
ODN H4   H N N 276 
ODN H5   H N N 277 
ODN H6   H N N 278 
ODN H7   H N N 279 
ODN H8   H N N 280 
ODN H9   H N N 281 
ODN H10  H N N 282 
ODN H11  H N N 283 
ODN H12  H N N 284 
ODN H13  H N N 285 
ODN H14  H N N 286 
ODN H15  H N N 287 
ODN H16  H N N 288 
ODN H17  H N N 289 
ODN H18  H N N 290 
ODN H19  H N N 291 
ODN H20  H N N 292 
ODN H21  H N N 293 
ODN H22  H N N 294 
ODN H23  H N N 295 
ODN H24  H N N 296 
ODN H25  H N N 297 
ODN H26  H N N 298 
ODN H27  H N N 299 
ODN H28  H N N 300 
ODN H29  H N N 301 
ODN H30  H N N 302 
PHE N    N N N 303 
PHE CA   C N S 304 
PHE C    C N N 305 
PHE O    O N N 306 
PHE CB   C N N 307 
PHE CG   C Y N 308 
PHE CD1  C Y N 309 
PHE CD2  C Y N 310 
PHE CE1  C Y N 311 
PHE CE2  C Y N 312 
PHE CZ   C Y N 313 
PHE OXT  O N N 314 
PHE H    H N N 315 
PHE H2   H N N 316 
PHE HA   H N N 317 
PHE HB2  H N N 318 
PHE HB3  H N N 319 
PHE HD1  H N N 320 
PHE HD2  H N N 321 
PHE HE1  H N N 322 
PHE HE2  H N N 323 
PHE HZ   H N N 324 
PHE HXT  H N N 325 
PRO N    N N N 326 
PRO CA   C N S 327 
PRO C    C N N 328 
PRO O    O N N 329 
PRO CB   C N N 330 
PRO CG   C N N 331 
PRO CD   C N N 332 
PRO OXT  O N N 333 
PRO H    H N N 334 
PRO HA   H N N 335 
PRO HB2  H N N 336 
PRO HB3  H N N 337 
PRO HG2  H N N 338 
PRO HG3  H N N 339 
PRO HD2  H N N 340 
PRO HD3  H N N 341 
PRO HXT  H N N 342 
SER N    N N N 343 
SER CA   C N S 344 
SER C    C N N 345 
SER O    O N N 346 
SER CB   C N N 347 
SER OG   O N N 348 
SER OXT  O N N 349 
SER H    H N N 350 
SER H2   H N N 351 
SER HA   H N N 352 
SER HB2  H N N 353 
SER HB3  H N N 354 
SER HG   H N N 355 
SER HXT  H N N 356 
THR N    N N N 357 
THR CA   C N S 358 
THR C    C N N 359 
THR O    O N N 360 
THR CB   C N R 361 
THR OG1  O N N 362 
THR CG2  C N N 363 
THR OXT  O N N 364 
THR H    H N N 365 
THR H2   H N N 366 
THR HA   H N N 367 
THR HB   H N N 368 
THR HG1  H N N 369 
THR HG21 H N N 370 
THR HG22 H N N 371 
THR HG23 H N N 372 
THR HXT  H N N 373 
TRP N    N N N 374 
TRP CA   C N S 375 
TRP C    C N N 376 
TRP O    O N N 377 
TRP CB   C N N 378 
TRP CG   C Y N 379 
TRP CD1  C Y N 380 
TRP CD2  C Y N 381 
TRP NE1  N Y N 382 
TRP CE2  C Y N 383 
TRP CE3  C Y N 384 
TRP CZ2  C Y N 385 
TRP CZ3  C Y N 386 
TRP CH2  C Y N 387 
TRP OXT  O N N 388 
TRP H    H N N 389 
TRP H2   H N N 390 
TRP HA   H N N 391 
TRP HB2  H N N 392 
TRP HB3  H N N 393 
TRP HD1  H N N 394 
TRP HE1  H N N 395 
TRP HE3  H N N 396 
TRP HZ2  H N N 397 
TRP HZ3  H N N 398 
TRP HH2  H N N 399 
TRP HXT  H N N 400 
TYR N    N N N 401 
TYR CA   C N S 402 
TYR C    C N N 403 
TYR O    O N N 404 
TYR CB   C N N 405 
TYR CG   C Y N 406 
TYR CD1  C Y N 407 
TYR CD2  C Y N 408 
TYR CE1  C Y N 409 
TYR CE2  C Y N 410 
TYR CZ   C Y N 411 
TYR OH   O N N 412 
TYR OXT  O N N 413 
TYR H    H N N 414 
TYR H2   H N N 415 
TYR HA   H N N 416 
TYR HB2  H N N 417 
TYR HB3  H N N 418 
TYR HD1  H N N 419 
TYR HD2  H N N 420 
TYR HE1  H N N 421 
TYR HE2  H N N 422 
TYR HH   H N N 423 
TYR HXT  H N N 424 
VAL N    N N N 425 
VAL CA   C N S 426 
VAL C    C N N 427 
VAL O    O N N 428 
VAL CB   C N N 429 
VAL CG1  C N N 430 
VAL CG2  C N N 431 
VAL OXT  O N N 432 
VAL H    H N N 433 
VAL H2   H N N 434 
VAL HA   H N N 435 
VAL HB   H N N 436 
VAL HG11 H N N 437 
VAL HG12 H N N 438 
VAL HG13 H N N 439 
VAL HG21 H N N 440 
VAL HG22 H N N 441 
VAL HG23 H N N 442 
VAL HXT  H N N 443 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
ODN C14 C13  sing N N 235 
ODN C13 C12  sing N N 236 
ODN C13 C17  sing N N 237 
ODN O2  C11  sing N N 238 
ODN C12 C11  sing N N 239 
ODN C12 C15  sing N N 240 
ODN C11 C10  sing N N 241 
ODN C15 C16  sing N N 242 
ODN C17 O3   doub N N 243 
ODN C17 C10  sing N N 244 
ODN O4  C18  sing N N 245 
ODN C10 C18  sing N N 246 
ODN C10 C9   sing N N 247 
ODN C16 C9   sing N N 248 
ODN C18 O1   sing N N 249 
ODN C18 C19  sing N N 250 
ODN O1  C8   sing N N 251 
ODN C9  C7   sing N N 252 
ODN O5  C19  sing N N 253 
ODN C8  C7   sing N N 254 
ODN C19 C6   sing N N 255 
ODN C7  C6   sing N N 256 
ODN C7  C    sing N N 257 
ODN C6  C3   sing N N 258 
ODN O   C    sing N N 259 
ODN C   C1   sing N N 260 
ODN C3  C4   sing N N 261 
ODN C3  C5   sing N N 262 
ODN C3  C2   sing N N 263 
ODN C1  C2   sing N N 264 
ODN O4  H1   sing N N 265 
ODN C8  H2   sing N N 266 
ODN C8  H3   sing N N 267 
ODN C19 H4   sing N N 268 
ODN O5  H5   sing N N 269 
ODN C6  H6   sing N N 270 
ODN C5  H7   sing N N 271 
ODN C5  H8   sing N N 272 
ODN C5  H9   sing N N 273 
ODN C4  H10  sing N N 274 
ODN C4  H11  sing N N 275 
ODN C4  H12  sing N N 276 
ODN C2  H13  sing N N 277 
ODN C2  H14  sing N N 278 
ODN C1  H15  sing N N 279 
ODN C1  H16  sing N N 280 
ODN C13 H17  sing N N 281 
ODN C14 H18  sing N N 282 
ODN C14 H19  sing N N 283 
ODN C14 H20  sing N N 284 
ODN C12 H21  sing N N 285 
ODN C11 H22  sing N N 286 
ODN O2  H23  sing N N 287 
ODN C15 H24  sing N N 288 
ODN C15 H25  sing N N 289 
ODN C16 H26  sing N N 290 
ODN C16 H27  sing N N 291 
ODN C9  H28  sing N N 292 
ODN C   H29  sing N N 293 
ODN O   H30  sing N N 294 
PHE N   CA   sing N N 295 
PHE N   H    sing N N 296 
PHE N   H2   sing N N 297 
PHE CA  C    sing N N 298 
PHE CA  CB   sing N N 299 
PHE CA  HA   sing N N 300 
PHE C   O    doub N N 301 
PHE C   OXT  sing N N 302 
PHE CB  CG   sing N N 303 
PHE CB  HB2  sing N N 304 
PHE CB  HB3  sing N N 305 
PHE CG  CD1  doub Y N 306 
PHE CG  CD2  sing Y N 307 
PHE CD1 CE1  sing Y N 308 
PHE CD1 HD1  sing N N 309 
PHE CD2 CE2  doub Y N 310 
PHE CD2 HD2  sing N N 311 
PHE CE1 CZ   doub Y N 312 
PHE CE1 HE1  sing N N 313 
PHE CE2 CZ   sing Y N 314 
PHE CE2 HE2  sing N N 315 
PHE CZ  HZ   sing N N 316 
PHE OXT HXT  sing N N 317 
PRO N   CA   sing N N 318 
PRO N   CD   sing N N 319 
PRO N   H    sing N N 320 
PRO CA  C    sing N N 321 
PRO CA  CB   sing N N 322 
PRO CA  HA   sing N N 323 
PRO C   O    doub N N 324 
PRO C   OXT  sing N N 325 
PRO CB  CG   sing N N 326 
PRO CB  HB2  sing N N 327 
PRO CB  HB3  sing N N 328 
PRO CG  CD   sing N N 329 
PRO CG  HG2  sing N N 330 
PRO CG  HG3  sing N N 331 
PRO CD  HD2  sing N N 332 
PRO CD  HD3  sing N N 333 
PRO OXT HXT  sing N N 334 
SER N   CA   sing N N 335 
SER N   H    sing N N 336 
SER N   H2   sing N N 337 
SER CA  C    sing N N 338 
SER CA  CB   sing N N 339 
SER CA  HA   sing N N 340 
SER C   O    doub N N 341 
SER C   OXT  sing N N 342 
SER CB  OG   sing N N 343 
SER CB  HB2  sing N N 344 
SER CB  HB3  sing N N 345 
SER OG  HG   sing N N 346 
SER OXT HXT  sing N N 347 
THR N   CA   sing N N 348 
THR N   H    sing N N 349 
THR N   H2   sing N N 350 
THR CA  C    sing N N 351 
THR CA  CB   sing N N 352 
THR CA  HA   sing N N 353 
THR C   O    doub N N 354 
THR C   OXT  sing N N 355 
THR CB  OG1  sing N N 356 
THR CB  CG2  sing N N 357 
THR CB  HB   sing N N 358 
THR OG1 HG1  sing N N 359 
THR CG2 HG21 sing N N 360 
THR CG2 HG22 sing N N 361 
THR CG2 HG23 sing N N 362 
THR OXT HXT  sing N N 363 
TRP N   CA   sing N N 364 
TRP N   H    sing N N 365 
TRP N   H2   sing N N 366 
TRP CA  C    sing N N 367 
TRP CA  CB   sing N N 368 
TRP CA  HA   sing N N 369 
TRP C   O    doub N N 370 
TRP C   OXT  sing N N 371 
TRP CB  CG   sing N N 372 
TRP CB  HB2  sing N N 373 
TRP CB  HB3  sing N N 374 
TRP CG  CD1  doub Y N 375 
TRP CG  CD2  sing Y N 376 
TRP CD1 NE1  sing Y N 377 
TRP CD1 HD1  sing N N 378 
TRP CD2 CE2  doub Y N 379 
TRP CD2 CE3  sing Y N 380 
TRP NE1 CE2  sing Y N 381 
TRP NE1 HE1  sing N N 382 
TRP CE2 CZ2  sing Y N 383 
TRP CE3 CZ3  doub Y N 384 
TRP CE3 HE3  sing N N 385 
TRP CZ2 CH2  doub Y N 386 
TRP CZ2 HZ2  sing N N 387 
TRP CZ3 CH2  sing Y N 388 
TRP CZ3 HZ3  sing N N 389 
TRP CH2 HH2  sing N N 390 
TRP OXT HXT  sing N N 391 
TYR N   CA   sing N N 392 
TYR N   H    sing N N 393 
TYR N   H2   sing N N 394 
TYR CA  C    sing N N 395 
TYR CA  CB   sing N N 396 
TYR CA  HA   sing N N 397 
TYR C   O    doub N N 398 
TYR C   OXT  sing N N 399 
TYR CB  CG   sing N N 400 
TYR CB  HB2  sing N N 401 
TYR CB  HB3  sing N N 402 
TYR CG  CD1  doub Y N 403 
TYR CG  CD2  sing Y N 404 
TYR CD1 CE1  sing Y N 405 
TYR CD1 HD1  sing N N 406 
TYR CD2 CE2  doub Y N 407 
TYR CD2 HD2  sing N N 408 
TYR CE1 CZ   doub Y N 409 
TYR CE1 HE1  sing N N 410 
TYR CE2 CZ   sing Y N 411 
TYR CE2 HE2  sing N N 412 
TYR CZ  OH   sing N N 413 
TYR OH  HH   sing N N 414 
TYR OXT HXT  sing N N 415 
VAL N   CA   sing N N 416 
VAL N   H    sing N N 417 
VAL N   H2   sing N N 418 
VAL CA  C    sing N N 419 
VAL CA  CB   sing N N 420 
VAL CA  HA   sing N N 421 
VAL C   O    doub N N 422 
VAL C   OXT  sing N N 423 
VAL CB  CG1  sing N N 424 
VAL CB  CG2  sing N N 425 
VAL CB  HB   sing N N 426 
VAL CG1 HG11 sing N N 427 
VAL CG1 HG12 sing N N 428 
VAL CG1 HG13 sing N N 429 
VAL CG2 HG21 sing N N 430 
VAL CG2 HG22 sing N N 431 
VAL CG2 HG23 sing N N 432 
VAL OXT HXT  sing N N 433 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-09-17 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9DNM 
_em_admin.last_update        2025-01-22 
_em_admin.map_release_date   2025-01-22 
_em_admin.title              'Structure of rat beta-arrestin 1 bound to allosteric inhibitor' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          10116 
_em_entity_assembly_naturalsource.organism             'Rattus norvegicus' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         57 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?           
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ?           
MASKING                         ? 3  ? ? ? ?         ?           
'CTF CORRECTION'                ? 4  1 ? ? cryoSPARC 4.4.1       
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?           
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?           
'MODEL FITTING'                 ? 7  ? 1 ? Coot      0.9.8.3     
'MODEL FITTING'                 ? 8  ? 1 ? ISOLDE    ?           
OTHER                           ? 9  ? ? ? ?         ?           
'MODEL REFINEMENT'              ? 10 ? 1 ? PHENIX    1.20.1-4487 
'INITIAL EULER ASSIGNMENT'      ? 11 1 ? ? ?         ?           
'FINAL EULER ASSIGNMENT'        ? 12 1 ? ? ?         ?           
CLASSIFICATION                  ? 13 1 ? ? ?         ?           
RECONSTRUCTION                  ? 14 1 ? ? cryoSPARC 4.4.1       
'VOLUME SELECTION'              ? 15 1 1 1 ?         ?           
'SERIES ALIGNMENT'              ? 16 1 1 1 ?         ?           
'MOLECULAR REPLACEMENT'         ? 17 1 1 1 ?         ?           
'LATTICE DISTORTION CORRECTION' ? 18 1 1 1 ?         ?           
'SYMMETRY DETERMINATION'        ? 19 1 1 1 ?         ?           
'CRYSTALLOGRAPHY MERGING'       ? 20 1 1 1 ?         ?           
# 
_em_specimen.concentration           7.5 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Howard Hughes Medical Institute (HHMI)'                                              'United States'  ?                1 
'National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)' 'United States'  HL016037         2 
'National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)' 'United States'  T32HL007101      3 
'National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)' 'United States'  HL16037-45S1     4 
'Human Frontier Science Program (HFSP)'                                               France           LT000174/2018    5 
'European Molecular Biology Organization (EMBO)'                                      'European Union' 'ALTF 1071-2017' 6 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 1G4M ? 
2 ? 'experimental model' PDB 6WW2 ? 
# 
_atom_sites.entry_id                    9DNM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 1   ? 181.076 180.561 227.927 1.00 60.20 ? 4   GLU H N   1 
ATOM   2    C CA  . GLU A 1 1   ? 181.557 181.132 226.676 1.00 60.20 ? 4   GLU H CA  1 
ATOM   3    C C   . GLU A 1 1   ? 183.070 180.991 226.555 1.00 60.20 ? 4   GLU H C   1 
ATOM   4    O O   . GLU A 1 1   ? 183.699 180.263 227.322 1.00 60.20 ? 4   GLU H O   1 
ATOM   5    C CB  . GLU A 1 1   ? 181.158 182.604 226.568 1.00 60.20 ? 4   GLU H CB  1 
ATOM   6    C CG  . GLU A 1 1   ? 179.664 182.855 226.691 1.00 60.20 ? 4   GLU H CG  1 
ATOM   7    C CD  . GLU A 1 1   ? 179.316 184.330 226.651 1.00 60.20 ? 4   GLU H CD  1 
ATOM   8    O OE1 . GLU A 1 1   ? 180.246 185.163 226.692 1.00 60.20 ? 4   GLU H OE1 1 
ATOM   9    O OE2 . GLU A 1 1   ? 178.113 184.656 226.580 1.00 60.20 ? 4   GLU H OE2 1 
ATOM   10   N N   . VAL A 1 2   ? 183.648 181.695 225.583 1.00 53.20 ? 5   VAL H N   1 
ATOM   11   C CA  . VAL A 1 2   ? 185.090 181.654 225.380 1.00 53.20 ? 5   VAL H CA  1 
ATOM   12   C C   . VAL A 1 2   ? 185.790 182.365 226.529 1.00 53.20 ? 5   VAL H C   1 
ATOM   13   O O   . VAL A 1 2   ? 185.429 183.489 226.902 1.00 53.20 ? 5   VAL H O   1 
ATOM   14   C CB  . VAL A 1 2   ? 185.454 182.270 224.022 1.00 53.20 ? 5   VAL H CB  1 
ATOM   15   C CG1 . VAL A 1 2   ? 184.813 183.630 223.876 1.00 53.20 ? 5   VAL H CG1 1 
ATOM   16   C CG2 . VAL A 1 2   ? 186.955 182.381 223.890 1.00 53.20 ? 5   VAL H CG2 1 
ATOM   17   N N   . GLN A 1 3   ? 186.787 181.704 227.108 1.00 51.80 ? 6   GLN H N   1 
ATOM   18   C CA  . GLN A 1 3   ? 187.498 182.234 228.261 1.00 51.80 ? 6   GLN H CA  1 
ATOM   19   C C   . GLN A 1 3   ? 188.774 181.430 228.458 1.00 51.80 ? 6   GLN H C   1 
ATOM   20   O O   . GLN A 1 3   ? 188.840 180.253 228.096 1.00 51.80 ? 6   GLN H O   1 
ATOM   21   C CB  . GLN A 1 3   ? 186.624 182.182 229.520 1.00 51.80 ? 6   GLN H CB  1 
ATOM   22   C CG  . GLN A 1 3   ? 187.148 182.984 230.693 1.00 51.80 ? 6   GLN H CG  1 
ATOM   23   C CD  . GLN A 1 3   ? 186.624 182.477 232.020 1.00 51.80 ? 6   GLN H CD  1 
ATOM   24   O OE1 . GLN A 1 3   ? 185.417 182.458 232.256 1.00 51.80 ? 6   GLN H OE1 1 
ATOM   25   N NE2 . GLN A 1 3   ? 187.531 182.062 232.895 1.00 51.80 ? 6   GLN H NE2 1 
ATOM   26   N N   . LEU A 1 4   ? 189.783 182.080 229.029 1.00 49.96 ? 7   LEU H N   1 
ATOM   27   C CA  . LEU A 1 4   ? 191.072 181.467 229.312 1.00 49.96 ? 7   LEU H CA  1 
ATOM   28   C C   . LEU A 1 4   ? 191.354 181.560 230.804 1.00 49.96 ? 7   LEU H C   1 
ATOM   29   O O   . LEU A 1 4   ? 191.134 182.608 231.419 1.00 49.96 ? 7   LEU H O   1 
ATOM   30   C CB  . LEU A 1 4   ? 192.198 182.156 228.532 1.00 49.96 ? 7   LEU H CB  1 
ATOM   31   C CG  . LEU A 1 4   ? 192.420 181.840 227.052 1.00 49.96 ? 7   LEU H CG  1 
ATOM   32   C CD1 . LEU A 1 4   ? 192.484 180.346 226.827 1.00 49.96 ? 7   LEU H CD1 1 
ATOM   33   C CD2 . LEU A 1 4   ? 191.357 182.477 226.178 1.00 49.96 ? 7   LEU H CD2 1 
ATOM   34   N N   . VAL A 1 5   ? 191.841 180.467 231.387 1.00 52.08 ? 8   VAL H N   1 
ATOM   35   C CA  . VAL A 1 5   ? 192.162 180.423 232.809 1.00 52.08 ? 8   VAL H CA  1 
ATOM   36   C C   . VAL A 1 5   ? 193.513 179.742 232.987 1.00 52.08 ? 8   VAL H C   1 
ATOM   37   O O   . VAL A 1 5   ? 193.807 178.735 232.335 1.00 52.08 ? 8   VAL H O   1 
ATOM   38   C CB  . VAL A 1 5   ? 191.055 179.712 233.620 1.00 52.08 ? 8   VAL H CB  1 
ATOM   39   C CG1 . VAL A 1 5   ? 190.814 178.305 233.102 1.00 52.08 ? 8   VAL H CG1 1 
ATOM   40   C CG2 . VAL A 1 5   ? 191.393 179.699 235.101 1.00 52.08 ? 8   VAL H CG2 1 
ATOM   41   N N   . GLU A 1 6   ? 194.345 180.309 233.858 1.00 52.03 ? 9   GLU H N   1 
ATOM   42   C CA  . GLU A 1 6   ? 195.685 179.807 234.117 1.00 52.03 ? 9   GLU H CA  1 
ATOM   43   C C   . GLU A 1 6   ? 195.920 179.716 235.618 1.00 52.03 ? 9   GLU H C   1 
ATOM   44   O O   . GLU A 1 6   ? 195.211 180.333 236.417 1.00 52.03 ? 9   GLU H O   1 
ATOM   45   C CB  . GLU A 1 6   ? 196.754 180.700 233.481 1.00 52.03 ? 9   GLU H CB  1 
ATOM   46   C CG  . GLU A 1 6   ? 196.473 182.179 233.579 1.00 52.03 ? 9   GLU H CG  1 
ATOM   47   C CD  . GLU A 1 6   ? 195.864 182.733 232.311 1.00 52.03 ? 9   GLU H CD  1 
ATOM   48   O OE1 . GLU A 1 6   ? 195.175 181.972 231.600 1.00 52.03 ? 9   GLU H OE1 1 
ATOM   49   O OE2 . GLU A 1 6   ? 196.076 183.929 232.022 1.00 52.03 ? 9   GLU H OE2 1 
ATOM   50   N N   . SER A 1 7   ? 196.930 178.937 235.997 1.00 51.67 ? 10  SER H N   1 
ATOM   51   C CA  . SER A 1 7   ? 197.246 178.736 237.405 1.00 51.67 ? 10  SER H CA  1 
ATOM   52   C C   . SER A 1 7   ? 198.712 178.355 237.534 1.00 51.67 ? 10  SER H C   1 
ATOM   53   O O   . SER A 1 7   ? 199.409 178.137 236.542 1.00 51.67 ? 10  SER H O   1 
ATOM   54   C CB  . SER A 1 7   ? 196.349 177.664 238.028 1.00 51.67 ? 10  SER H CB  1 
ATOM   55   O OG  . SER A 1 7   ? 196.856 176.367 237.772 1.00 51.67 ? 10  SER H OG  1 
ATOM   56   N N   . GLY A 1 8   ? 199.173 178.287 238.779 1.00 51.77 ? 11  GLY H N   1 
ATOM   57   C CA  . GLY A 1 8   ? 200.518 177.851 239.095 1.00 51.77 ? 11  GLY H CA  1 
ATOM   58   C C   . GLY A 1 8   ? 201.420 178.920 239.668 1.00 51.77 ? 11  GLY H C   1 
ATOM   59   O O   . GLY A 1 8   ? 202.530 178.595 240.106 1.00 51.77 ? 11  GLY H O   1 
ATOM   60   N N   . GLY A 1 9   ? 200.991 180.175 239.681 1.00 49.88 ? 12  GLY H N   1 
ATOM   61   C CA  . GLY A 1 9   ? 201.830 181.248 240.167 1.00 49.88 ? 12  GLY H CA  1 
ATOM   62   C C   . GLY A 1 9   ? 202.250 181.100 241.612 1.00 49.88 ? 12  GLY H C   1 
ATOM   63   O O   . GLY A 1 9   ? 201.423 180.803 242.478 1.00 49.88 ? 12  GLY H O   1 
ATOM   64   N N   . GLY A 1 10  ? 203.531 181.310 241.886 1.00 50.79 ? 13  GLY H N   1 
ATOM   65   C CA  . GLY A 1 10  ? 204.023 181.208 243.246 1.00 50.79 ? 13  GLY H CA  1 
ATOM   66   C C   . GLY A 1 10  ? 205.413 181.789 243.361 1.00 50.79 ? 13  GLY H C   1 
ATOM   67   O O   . GLY A 1 10  ? 205.993 182.280 242.390 1.00 50.79 ? 13  GLY H O   1 
ATOM   68   N N   . LEU A 1 11  ? 205.940 181.729 244.579 1.00 51.71 ? 14  LEU H N   1 
ATOM   69   C CA  . LEU A 1 11  ? 207.275 182.214 244.896 1.00 51.71 ? 14  LEU H CA  1 
ATOM   70   C C   . LEU A 1 11  ? 208.242 181.042 244.865 1.00 51.71 ? 14  LEU H C   1 
ATOM   71   O O   . LEU A 1 11  ? 207.989 180.008 245.491 1.00 51.71 ? 14  LEU H O   1 
ATOM   72   C CB  . LEU A 1 11  ? 207.294 182.881 246.270 1.00 51.71 ? 14  LEU H CB  1 
ATOM   73   C CG  . LEU A 1 11  ? 208.173 184.112 246.481 1.00 51.71 ? 14  LEU H CG  1 
ATOM   74   C CD1 . LEU A 1 11  ? 207.920 184.693 247.861 1.00 51.71 ? 14  LEU H CD1 1 
ATOM   75   C CD2 . LEU A 1 11  ? 209.646 183.779 246.305 1.00 51.71 ? 14  LEU H CD2 1 
ATOM   76   N N   . VAL A 1 12  ? 209.342 181.200 244.140 1.00 51.37 ? 15  VAL H N   1 
ATOM   77   C CA  . VAL A 1 12  ? 210.309 180.128 243.948 1.00 51.37 ? 15  VAL H CA  1 
ATOM   78   C C   . VAL A 1 12  ? 211.715 180.688 244.098 1.00 51.37 ? 15  VAL H C   1 
ATOM   79   O O   . VAL A 1 12  ? 211.991 181.821 243.691 1.00 51.37 ? 15  VAL H O   1 
ATOM   80   C CB  . VAL A 1 12  ? 210.129 179.454 242.577 1.00 51.37 ? 15  VAL H CB  1 
ATOM   81   C CG1 . VAL A 1 12  ? 208.832 178.666 242.541 1.00 51.37 ? 15  VAL H CG1 1 
ATOM   82   C CG2 . VAL A 1 12  ? 210.124 180.504 241.493 1.00 51.37 ? 15  VAL H CG2 1 
ATOM   83   N N   . GLN A 1 13  ? 212.600 179.893 244.688 1.00 52.17 ? 16  GLN H N   1 
ATOM   84   C CA  . GLN A 1 13  ? 213.986 180.295 244.835 1.00 52.17 ? 16  GLN H CA  1 
ATOM   85   C C   . GLN A 1 13  ? 214.679 180.318 243.473 1.00 52.17 ? 16  GLN H C   1 
ATOM   86   O O   . GLN A 1 13  ? 214.295 179.579 242.564 1.00 52.17 ? 16  GLN H O   1 
ATOM   87   C CB  . GLN A 1 13  ? 214.718 179.339 245.773 1.00 52.17 ? 16  GLN H CB  1 
ATOM   88   C CG  . GLN A 1 13  ? 214.400 179.502 247.261 1.00 52.17 ? 16  GLN H CG  1 
ATOM   89   C CD  . GLN A 1 13  ? 214.763 180.870 247.822 1.00 52.17 ? 16  GLN H CD  1 
ATOM   90   O OE1 . GLN A 1 13  ? 214.199 181.891 247.433 1.00 52.17 ? 16  GLN H OE1 1 
ATOM   91   N NE2 . GLN A 1 13  ? 215.715 180.890 248.745 1.00 52.17 ? 16  GLN H NE2 1 
ATOM   92   N N   . PRO A 1 14  ? 215.692 181.168 243.302 1.00 51.73 ? 17  PRO H N   1 
ATOM   93   C CA  . PRO A 1 14  ? 216.436 181.173 242.038 1.00 51.73 ? 17  PRO H CA  1 
ATOM   94   C C   . PRO A 1 14  ? 217.090 179.823 241.800 1.00 51.73 ? 17  PRO H C   1 
ATOM   95   O O   . PRO A 1 14  ? 217.588 179.180 242.725 1.00 51.73 ? 17  PRO H O   1 
ATOM   96   C CB  . PRO A 1 14  ? 217.478 182.279 242.233 1.00 51.73 ? 17  PRO H CB  1 
ATOM   97   C CG  . PRO A 1 14  ? 217.006 183.075 243.380 1.00 51.73 ? 17  PRO H CG  1 
ATOM   98   C CD  . PRO A 1 14  ? 216.220 182.156 244.253 1.00 51.73 ? 17  PRO H CD  1 
ATOM   99   N N   . GLY A 1 15  ? 217.085 179.396 240.543 1.00 54.61 ? 18  GLY H N   1 
ATOM   100  C CA  . GLY A 1 15  ? 217.467 178.042 240.223 1.00 54.61 ? 18  GLY H CA  1 
ATOM   101  C C   . GLY A 1 15  ? 216.374 177.024 240.444 1.00 54.61 ? 18  GLY H C   1 
ATOM   102  O O   . GLY A 1 15  ? 216.595 175.835 240.184 1.00 54.61 ? 18  GLY H O   1 
ATOM   103  N N   . GLY A 1 16  ? 215.203 177.451 240.917 1.00 53.71 ? 19  GLY H N   1 
ATOM   104  C CA  . GLY A 1 16  ? 214.085 176.559 241.117 1.00 53.71 ? 19  GLY H CA  1 
ATOM   105  C C   . GLY A 1 16  ? 213.269 176.366 239.854 1.00 53.71 ? 19  GLY H C   1 
ATOM   106  O O   . GLY A 1 16  ? 213.512 176.972 238.813 1.00 53.71 ? 19  GLY H O   1 
ATOM   107  N N   . SER A 1 17  ? 212.273 175.498 239.964 1.00 53.35 ? 20  SER H N   1 
ATOM   108  C CA  . SER A 1 17  ? 211.422 175.149 238.843 1.00 53.35 ? 20  SER H CA  1 
ATOM   109  C C   . SER A 1 17  ? 209.964 175.284 239.248 1.00 53.35 ? 20  SER H C   1 
ATOM   110  O O   . SER A 1 17  ? 209.602 175.076 240.408 1.00 53.35 ? 20  SER H O   1 
ATOM   111  C CB  . SER A 1 17  ? 211.698 173.723 238.355 1.00 53.35 ? 20  SER H CB  1 
ATOM   112  O OG  . SER A 1 17  ? 213.077 173.532 238.095 1.00 53.35 ? 20  SER H OG  1 
ATOM   113  N N   . LEU A 1 18  ? 209.129 175.632 238.273 1.00 49.90 ? 21  LEU H N   1 
ATOM   114  C CA  . LEU A 1 18  ? 207.705 175.808 238.508 1.00 49.90 ? 21  LEU H CA  1 
ATOM   115  C C   . LEU A 1 18  ? 206.965 175.553 237.205 1.00 49.90 ? 21  LEU H C   1 
ATOM   116  O O   . LEU A 1 18  ? 207.488 175.810 236.119 1.00 49.90 ? 21  LEU H O   1 
ATOM   117  C CB  . LEU A 1 18  ? 207.405 177.210 239.047 1.00 49.90 ? 21  LEU H CB  1 
ATOM   118  C CG  . LEU A 1 18  ? 205.947 177.632 239.164 1.00 49.90 ? 21  LEU H CG  1 
ATOM   119  C CD1 . LEU A 1 18  ? 205.280 176.872 240.292 1.00 49.90 ? 21  LEU H CD1 1 
ATOM   120  C CD2 . LEU A 1 18  ? 205.851 179.127 239.392 1.00 49.90 ? 21  LEU H CD2 1 
ATOM   121  N N   . ARG A 1 19  ? 205.748 175.035 237.320 1.00 50.82 ? 22  ARG H N   1 
ATOM   122  C CA  . ARG A 1 19  ? 204.922 174.719 236.167 1.00 50.82 ? 22  ARG H CA  1 
ATOM   123  C C   . ARG A 1 19  ? 203.717 175.646 236.110 1.00 50.82 ? 22  ARG H C   1 
ATOM   124  O O   . ARG A 1 19  ? 203.072 175.907 237.130 1.00 50.82 ? 22  ARG H O   1 
ATOM   125  C CB  . ARG A 1 19  ? 204.454 173.264 236.204 1.00 50.82 ? 22  ARG H CB  1 
ATOM   126  C CG  . ARG A 1 19  ? 203.643 172.852 234.985 1.00 50.82 ? 22  ARG H CG  1 
ATOM   127  C CD  . ARG A 1 19  ? 203.163 171.418 235.087 1.00 50.82 ? 22  ARG H CD  1 
ATOM   128  N NE  . ARG A 1 19  ? 204.275 170.478 235.040 1.00 50.82 ? 22  ARG H NE  1 
ATOM   129  C CZ  . ARG A 1 19  ? 204.831 170.039 233.921 1.00 50.82 ? 22  ARG H CZ  1 
ATOM   130  N NH1 . ARG A 1 19  ? 204.395 170.427 232.735 1.00 50.82 ? 22  ARG H NH1 1 
ATOM   131  N NH2 . ARG A 1 19  ? 205.855 169.194 233.993 1.00 50.82 ? 22  ARG H NH2 1 
ATOM   132  N N   . LEU A 1 20  ? 203.423 176.139 234.912 1.00 49.74 ? 23  LEU H N   1 
ATOM   133  C CA  . LEU A 1 20  ? 202.281 177.002 234.661 1.00 49.74 ? 23  LEU H CA  1 
ATOM   134  C C   . LEU A 1 20  ? 201.390 176.337 233.626 1.00 49.74 ? 23  LEU H C   1 
ATOM   135  O O   . LEU A 1 20  ? 201.884 175.753 232.659 1.00 49.74 ? 23  LEU H O   1 
ATOM   136  C CB  . LEU A 1 20  ? 202.723 178.383 234.164 1.00 49.74 ? 23  LEU H CB  1 
ATOM   137  C CG  . LEU A 1 20  ? 202.879 179.499 235.195 1.00 49.74 ? 23  LEU H CG  1 
ATOM   138  C CD1 . LEU A 1 20  ? 203.980 179.166 236.178 1.00 49.74 ? 23  LEU H CD1 1 
ATOM   139  C CD2 . LEU A 1 20  ? 203.167 180.818 234.510 1.00 49.74 ? 23  LEU H CD2 1 
ATOM   140  N N   . SER A 1 21  ? 200.081 176.419 233.832 1.00 50.72 ? 24  SER H N   1 
ATOM   141  C CA  . SER A 1 21  ? 199.110 175.810 232.939 1.00 50.72 ? 24  SER H CA  1 
ATOM   142  C C   . SER A 1 21  ? 198.227 176.887 232.330 1.00 50.72 ? 24  SER H C   1 
ATOM   143  O O   . SER A 1 21  ? 197.990 177.931 232.941 1.00 50.72 ? 24  SER H O   1 
ATOM   144  C CB  . SER A 1 21  ? 198.241 174.786 233.672 1.00 50.72 ? 24  SER H CB  1 
ATOM   145  O OG  . SER A 1 21  ? 199.035 173.895 234.433 1.00 50.72 ? 24  SER H OG  1 
ATOM   146  N N   . CYS A 1 22  ? 197.748 176.632 231.116 1.00 55.46 ? 25  CYS H N   1 
ATOM   147  C CA  . CYS A 1 22  ? 196.818 177.522 230.426 1.00 55.46 ? 25  CYS H CA  1 
ATOM   148  C C   . CYS A 1 22  ? 195.602 176.699 230.024 1.00 55.46 ? 25  CYS H C   1 
ATOM   149  O O   . CYS A 1 22  ? 195.532 176.176 228.909 1.00 55.46 ? 25  CYS H O   1 
ATOM   150  C CB  . CYS A 1 22  ? 197.472 178.179 229.217 1.00 55.46 ? 25  CYS H CB  1 
ATOM   151  S SG  . CYS A 1 22  ? 196.407 179.342 228.332 1.00 55.46 ? 25  CYS H SG  1 
ATOM   152  N N   . ALA A 1 23  ? 194.641 176.586 230.934 1.00 54.44 ? 26  ALA H N   1 
ATOM   153  C CA  . ALA A 1 23  ? 193.418 175.850 230.655 1.00 54.44 ? 26  ALA H CA  1 
ATOM   154  C C   . ALA A 1 23  ? 192.474 176.709 229.827 1.00 54.44 ? 26  ALA H C   1 
ATOM   155  O O   . ALA A 1 23  ? 192.257 177.884 230.136 1.00 54.44 ? 26  ALA H O   1 
ATOM   156  C CB  . ALA A 1 23  ? 192.742 175.418 231.954 1.00 54.44 ? 26  ALA H CB  1 
ATOM   157  N N   . ALA A 1 24  ? 191.914 176.123 228.779 1.00 52.17 ? 27  ALA H N   1 
ATOM   158  C CA  . ALA A 1 24  ? 191.000 176.818 227.888 1.00 52.17 ? 27  ALA H CA  1 
ATOM   159  C C   . ALA A 1 24  ? 189.630 176.165 227.955 1.00 52.17 ? 27  ALA H C   1 
ATOM   160  O O   . ALA A 1 24  ? 189.516 174.936 227.974 1.00 52.17 ? 27  ALA H O   1 
ATOM   161  C CB  . ALA A 1 24  ? 191.514 176.806 226.451 1.00 52.17 ? 27  ALA H CB  1 
ATOM   162  N N   . SER A 1 25  ? 188.594 176.992 227.996 1.00 48.83 ? 28  SER H N   1 
ATOM   163  C CA  . SER A 1 25  ? 187.221 176.523 227.997 1.00 48.83 ? 28  SER H CA  1 
ATOM   164  C C   . SER A 1 25  ? 186.449 177.242 226.904 1.00 48.83 ? 28  SER H C   1 
ATOM   165  O O   . SER A 1 25  ? 186.738 178.395 226.573 1.00 48.83 ? 28  SER H O   1 
ATOM   166  C CB  . SER A 1 25  ? 186.544 176.751 229.349 1.00 48.83 ? 28  SER H CB  1 
ATOM   167  O OG  . SER A 1 25  ? 186.442 178.135 229.638 1.00 48.83 ? 28  SER H OG  1 
ATOM   168  N N   . GLY A 1 26  ? 185.465 176.550 226.347 1.00 48.19 ? 29  GLY H N   1 
ATOM   169  C CA  . GLY A 1 26  ? 184.656 177.101 225.288 1.00 48.19 ? 29  GLY H CA  1 
ATOM   170  C C   . GLY A 1 26  ? 185.228 176.948 223.899 1.00 48.19 ? 29  GLY H C   1 
ATOM   171  O O   . GLY A 1 26  ? 184.553 177.312 222.929 1.00 48.19 ? 29  GLY H O   1 
ATOM   172  N N   . PHE A 1 27  ? 186.442 176.424 223.766 1.00 48.86 ? 30  PHE H N   1 
ATOM   173  C CA  . PHE A 1 27  ? 187.018 176.198 222.451 1.00 48.86 ? 30  PHE H CA  1 
ATOM   174  C C   . PHE A 1 27  ? 188.116 175.152 222.560 1.00 48.86 ? 30  PHE H C   1 
ATOM   175  O O   . PHE A 1 27  ? 188.865 175.130 223.538 1.00 48.86 ? 30  PHE H O   1 
ATOM   176  C CB  . PHE A 1 27  ? 187.567 177.497 221.853 1.00 48.86 ? 30  PHE H CB  1 
ATOM   177  C CG  . PHE A 1 27  ? 188.800 178.011 222.534 1.00 48.86 ? 30  PHE H CG  1 
ATOM   178  C CD1 . PHE A 1 27  ? 188.716 178.663 223.747 1.00 48.86 ? 30  PHE H CD1 1 
ATOM   179  C CD2 . PHE A 1 27  ? 190.039 177.858 221.950 1.00 48.86 ? 30  PHE H CD2 1 
ATOM   180  C CE1 . PHE A 1 27  ? 189.845 179.138 224.367 1.00 48.86 ? 30  PHE H CE1 1 
ATOM   181  C CE2 . PHE A 1 27  ? 191.169 178.329 222.566 1.00 48.86 ? 30  PHE H CE2 1 
ATOM   182  C CZ  . PHE A 1 27  ? 191.074 178.972 223.774 1.00 48.86 ? 30  PHE H CZ  1 
ATOM   183  N N   . ASN A 1 28  ? 188.200 174.291 221.551 1.00 50.93 ? 31  ASN H N   1 
ATOM   184  C CA  . ASN A 1 28  ? 189.252 173.287 221.511 1.00 50.93 ? 31  ASN H CA  1 
ATOM   185  C C   . ASN A 1 28  ? 190.596 173.942 221.230 1.00 50.93 ? 31  ASN H C   1 
ATOM   186  O O   . ASN A 1 28  ? 190.700 174.863 220.416 1.00 50.93 ? 31  ASN H O   1 
ATOM   187  C CB  . ASN A 1 28  ? 188.942 172.236 220.447 1.00 50.93 ? 31  ASN H CB  1 
ATOM   188  C CG  . ASN A 1 28  ? 187.862 171.266 220.882 1.00 50.93 ? 31  ASN H CG  1 
ATOM   189  O OD1 . ASN A 1 28  ? 186.699 171.637 221.026 1.00 50.93 ? 31  ASN H OD1 1 
ATOM   190  N ND2 . ASN A 1 28  ? 188.244 170.013 221.094 1.00 50.93 ? 31  ASN H ND2 1 
ATOM   191  N N   . VAL A 1 29  ? 191.633 173.459 221.914 1.00 51.52 ? 32  VAL H N   1 
ATOM   192  C CA  . VAL A 1 29  ? 192.957 174.055 221.779 1.00 51.52 ? 32  VAL H CA  1 
ATOM   193  C C   . VAL A 1 29  ? 193.533 173.783 220.395 1.00 51.52 ? 32  VAL H C   1 
ATOM   194  O O   . VAL A 1 29  ? 194.179 174.652 219.797 1.00 51.52 ? 32  VAL H O   1 
ATOM   195  C CB  . VAL A 1 29  ? 193.882 173.540 222.895 1.00 51.52 ? 32  VAL H CB  1 
ATOM   196  C CG1 . VAL A 1 29  ? 195.335 173.807 222.559 1.00 51.52 ? 32  VAL H CG1 1 
ATOM   197  C CG2 . VAL A 1 29  ? 193.518 174.186 224.219 1.00 51.52 ? 32  VAL H CG2 1 
ATOM   198  N N   . VAL A 1 30  ? 193.289 172.589 219.850 1.00 51.06 ? 33  VAL H N   1 
ATOM   199  C CA  . VAL A 1 30  ? 193.903 172.176 218.595 1.00 51.06 ? 33  VAL H CA  1 
ATOM   200  C C   . VAL A 1 30  ? 193.536 173.071 217.423 1.00 51.06 ? 33  VAL H C   1 
ATOM   201  O O   . VAL A 1 30  ? 194.186 173.003 216.378 1.00 51.06 ? 33  VAL H O   1 
ATOM   202  C CB  . VAL A 1 30  ? 193.536 170.714 218.269 1.00 51.06 ? 33  VAL H CB  1 
ATOM   203  C CG1 . VAL A 1 30  ? 194.324 169.767 219.147 1.00 51.06 ? 33  VAL H CG1 1 
ATOM   204  C CG2 . VAL A 1 30  ? 192.045 170.493 218.438 1.00 51.06 ? 33  VAL H CG2 1 
ATOM   205  N N   . ASP A 1 31  ? 192.512 173.903 217.561 1.00 50.24 ? 34  ASP H N   1 
ATOM   206  C CA  . ASP A 1 31  ? 192.131 174.829 216.509 1.00 50.24 ? 34  ASP H CA  1 
ATOM   207  C C   . ASP A 1 31  ? 192.761 176.204 216.677 1.00 50.24 ? 34  ASP H C   1 
ATOM   208  O O   . ASP A 1 31  ? 192.438 177.116 215.910 1.00 50.24 ? 34  ASP H O   1 
ATOM   209  C CB  . ASP A 1 31  ? 190.608 174.958 216.447 1.00 50.24 ? 34  ASP H CB  1 
ATOM   210  C CG  . ASP A 1 31  ? 189.960 173.808 215.707 1.00 50.24 ? 34  ASP H CG  1 
ATOM   211  O OD1 . ASP A 1 31  ? 190.682 173.080 214.996 1.00 50.24 ? 34  ASP H OD1 1 
ATOM   212  O OD2 . ASP A 1 31  ? 188.730 173.633 215.835 1.00 50.24 ? 34  ASP H OD2 1 
ATOM   213  N N   . PHE A 1 32  ? 193.647 176.377 217.655 1.00 46.79 ? 35  PHE H N   1 
ATOM   214  C CA  . PHE A 1 32  ? 194.249 177.677 217.904 1.00 46.79 ? 35  PHE H CA  1 
ATOM   215  C C   . PHE A 1 32  ? 195.668 177.495 218.419 1.00 46.79 ? 35  PHE H C   1 
ATOM   216  O O   . PHE A 1 32  ? 196.051 176.421 218.884 1.00 46.79 ? 35  PHE H O   1 
ATOM   217  C CB  . PHE A 1 32  ? 193.422 178.490 218.899 1.00 46.79 ? 35  PHE H CB  1 
ATOM   218  C CG  . PHE A 1 32  ? 192.110 178.954 218.353 1.00 46.79 ? 35  PHE H CG  1 
ATOM   219  C CD1 . PHE A 1 32  ? 192.027 180.124 217.619 1.00 46.79 ? 35  PHE H CD1 1 
ATOM   220  C CD2 . PHE A 1 32  ? 190.960 178.223 218.568 1.00 46.79 ? 35  PHE H CD2 1 
ATOM   221  C CE1 . PHE A 1 32  ? 190.819 180.555 217.112 1.00 46.79 ? 35  PHE H CE1 1 
ATOM   222  C CE2 . PHE A 1 32  ? 189.750 178.647 218.065 1.00 46.79 ? 35  PHE H CE2 1 
ATOM   223  C CZ  . PHE A 1 32  ? 189.679 179.815 217.335 1.00 46.79 ? 35  PHE H CZ  1 
ATOM   224  N N   . SER A 1 33  ? 196.447 178.565 218.319 1.00 43.48 ? 36  SER H N   1 
ATOM   225  C CA  . SER A 1 33  ? 197.809 178.605 218.822 1.00 43.48 ? 36  SER H CA  1 
ATOM   226  C C   . SER A 1 33  ? 197.861 179.475 220.068 1.00 43.48 ? 36  SER H C   1 
ATOM   227  O O   . SER A 1 33  ? 197.300 180.574 220.093 1.00 43.48 ? 36  SER H O   1 
ATOM   228  C CB  . SER A 1 33  ? 198.769 179.148 217.766 1.00 43.48 ? 36  SER H CB  1 
ATOM   229  O OG  . SER A 1 33  ? 198.547 180.526 217.550 1.00 43.48 ? 36  SER H OG  1 
ATOM   230  N N   . LEU A 1 34  ? 198.537 178.980 221.100 1.00 44.40 ? 37  LEU H N   1 
ATOM   231  C CA  . LEU A 1 34  ? 198.578 179.630 222.402 1.00 44.40 ? 37  LEU H CA  1 
ATOM   232  C C   . LEU A 1 34  ? 199.962 180.199 222.668 1.00 44.40 ? 37  LEU H C   1 
ATOM   233  O O   . LEU A 1 34  ? 200.975 179.547 222.401 1.00 44.40 ? 37  LEU H O   1 
ATOM   234  C CB  . LEU A 1 34  ? 198.196 178.650 223.508 1.00 44.40 ? 37  LEU H CB  1 
ATOM   235  C CG  . LEU A 1 34  ? 197.066 177.695 223.138 1.00 44.40 ? 37  LEU H CG  1 
ATOM   236  C CD1 . LEU A 1 34  ? 196.875 176.663 224.222 1.00 44.40 ? 37  LEU H CD1 1 
ATOM   237  C CD2 . LEU A 1 34  ? 195.781 178.464 222.905 1.00 44.40 ? 37  LEU H CD2 1 
ATOM   238  N N   . HIS A 1 35  ? 199.994 181.414 223.205 1.00 41.71 ? 38  HIS H N   1 
ATOM   239  C CA  . HIS A 1 35  ? 201.227 182.140 223.448 1.00 41.71 ? 38  HIS H CA  1 
ATOM   240  C C   . HIS A 1 35  ? 201.294 182.544 224.912 1.00 41.71 ? 38  HIS H C   1 
ATOM   241  O O   . HIS A 1 35  ? 200.304 182.471 225.643 1.00 41.71 ? 38  HIS H O   1 
ATOM   242  C CB  . HIS A 1 35  ? 201.329 183.377 222.549 1.00 41.71 ? 38  HIS H CB  1 
ATOM   243  C CG  . HIS A 1 35  ? 201.199 183.072 221.091 1.00 41.71 ? 38  HIS H CG  1 
ATOM   244  N ND1 . HIS A 1 35  ? 202.224 183.279 220.195 1.00 41.71 ? 38  HIS H ND1 1 
ATOM   245  C CD2 . HIS A 1 35  ? 200.171 182.562 220.375 1.00 41.71 ? 38  HIS H CD2 1 
ATOM   246  C CE1 . HIS A 1 35  ? 201.830 182.914 218.989 1.00 41.71 ? 38  HIS H CE1 1 
ATOM   247  N NE2 . HIS A 1 35  ? 200.588 182.476 219.071 1.00 41.71 ? 38  HIS H NE2 1 
ATOM   248  N N   . TRP A 1 36  ? 202.476 182.975 225.334 1.00 43.70 ? 39  TRP H N   1 
ATOM   249  C CA  . TRP A 1 36  ? 202.703 183.429 226.699 1.00 43.70 ? 39  TRP H CA  1 
ATOM   250  C C   . TRP A 1 36  ? 203.263 184.841 226.662 1.00 43.70 ? 39  TRP H C   1 
ATOM   251  O O   . TRP A 1 36  ? 204.282 185.091 226.012 1.00 43.70 ? 39  TRP H O   1 
ATOM   252  C CB  . TRP A 1 36  ? 203.644 182.477 227.432 1.00 43.70 ? 39  TRP H CB  1 
ATOM   253  C CG  . TRP A 1 36  ? 202.980 181.191 227.757 1.00 43.70 ? 39  TRP H CG  1 
ATOM   254  C CD1 . TRP A 1 36  ? 203.027 180.043 227.031 1.00 43.70 ? 39  TRP H CD1 1 
ATOM   255  C CD2 . TRP A 1 36  ? 202.137 180.924 228.880 1.00 43.70 ? 39  TRP H CD2 1 
ATOM   256  N NE1 . TRP A 1 36  ? 202.273 179.072 227.639 1.00 43.70 ? 39  TRP H NE1 1 
ATOM   257  C CE2 . TRP A 1 36  ? 201.718 179.590 228.777 1.00 43.70 ? 39  TRP H CE2 1 
ATOM   258  C CE3 . TRP A 1 36  ? 201.705 181.683 229.968 1.00 43.70 ? 39  TRP H CE3 1 
ATOM   259  C CZ2 . TRP A 1 36  ? 200.886 178.998 229.717 1.00 43.70 ? 39  TRP H CZ2 1 
ATOM   260  C CZ3 . TRP A 1 36  ? 200.879 181.095 230.899 1.00 43.70 ? 39  TRP H CZ3 1 
ATOM   261  C CH2 . TRP A 1 36  ? 200.477 179.766 230.768 1.00 43.70 ? 39  TRP H CH2 1 
ATOM   262  N N   . VAL A 1 37  ? 202.595 185.760 227.353 1.00 41.78 ? 40  VAL H N   1 
ATOM   263  C CA  . VAL A 1 37  ? 202.979 187.164 227.395 1.00 41.78 ? 40  VAL H CA  1 
ATOM   264  C C   . VAL A 1 37  ? 203.233 187.542 228.845 1.00 41.78 ? 40  VAL H C   1 
ATOM   265  O O   . VAL A 1 37  ? 202.377 187.323 229.709 1.00 41.78 ? 40  VAL H O   1 
ATOM   266  C CB  . VAL A 1 37  ? 201.900 188.065 226.770 1.00 41.78 ? 40  VAL H CB  1 
ATOM   267  C CG1 . VAL A 1 37  ? 202.057 189.496 227.251 1.00 41.78 ? 40  VAL H CG1 1 
ATOM   268  C CG2 . VAL A 1 37  ? 201.970 188.004 225.258 1.00 41.78 ? 40  VAL H CG2 1 
ATOM   269  N N   . ARG A 1 38  ? 204.405 188.107 229.107 1.00 43.89 ? 41  ARG H N   1 
ATOM   270  C CA  . ARG A 1 38  ? 204.866 188.423 230.449 1.00 43.89 ? 41  ARG H CA  1 
ATOM   271  C C   . ARG A 1 38  ? 204.993 189.930 230.605 1.00 43.89 ? 41  ARG H C   1 
ATOM   272  O O   . ARG A 1 38  ? 205.508 190.609 229.712 1.00 43.89 ? 41  ARG H O   1 
ATOM   273  C CB  . ARG A 1 38  ? 206.211 187.737 230.715 1.00 43.89 ? 41  ARG H CB  1 
ATOM   274  C CG  . ARG A 1 38  ? 207.108 188.431 231.708 1.00 43.89 ? 41  ARG H CG  1 
ATOM   275  C CD  . ARG A 1 38  ? 208.402 187.657 231.902 1.00 43.89 ? 41  ARG H CD  1 
ATOM   276  N NE  . ARG A 1 38  ? 209.381 187.944 230.861 1.00 43.89 ? 41  ARG H NE  1 
ATOM   277  C CZ  . ARG A 1 38  ? 210.554 187.336 230.748 1.00 43.89 ? 41  ARG H CZ  1 
ATOM   278  N NH1 . ARG A 1 38  ? 210.922 186.383 231.584 1.00 43.89 ? 41  ARG H NH1 1 
ATOM   279  N NH2 . ARG A 1 38  ? 211.378 187.693 229.769 1.00 43.89 ? 41  ARG H NH2 1 
ATOM   280  N N   . GLN A 1 39  ? 204.523 190.457 231.734 1.00 43.79 ? 42  GLN H N   1 
ATOM   281  C CA  . GLN A 1 39  ? 204.553 191.894 231.991 1.00 43.79 ? 42  GLN H CA  1 
ATOM   282  C C   . GLN A 1 39  ? 205.243 192.144 233.321 1.00 43.79 ? 42  GLN H C   1 
ATOM   283  O O   . GLN A 1 39  ? 204.715 191.781 234.376 1.00 43.79 ? 42  GLN H O   1 
ATOM   284  C CB  . GLN A 1 39  ? 203.144 192.488 231.993 1.00 43.79 ? 42  GLN H CB  1 
ATOM   285  C CG  . GLN A 1 39  ? 203.039 193.838 232.692 1.00 43.79 ? 42  GLN H CG  1 
ATOM   286  C CD  . GLN A 1 39  ? 201.867 194.672 232.209 1.00 43.79 ? 42  GLN H CD  1 
ATOM   287  O OE1 . GLN A 1 39  ? 201.832 195.109 231.063 1.00 43.79 ? 42  GLN H OE1 1 
ATOM   288  N NE2 . GLN A 1 39  ? 200.903 194.902 233.090 1.00 43.79 ? 42  GLN H NE2 1 
ATOM   289  N N   . ALA A 1 40  ? 206.413 192.768 233.270 1.00 45.95 ? 43  ALA H N   1 
ATOM   290  C CA  . ALA A 1 40  ? 207.113 193.141 234.483 1.00 45.95 ? 43  ALA H CA  1 
ATOM   291  C C   . ALA A 1 40  ? 206.331 194.222 235.225 1.00 45.95 ? 43  ALA H C   1 
ATOM   292  O O   . ALA A 1 40  ? 205.577 194.982 234.615 1.00 45.95 ? 43  ALA H O   1 
ATOM   293  C CB  . ALA A 1 40  ? 208.513 193.643 234.153 1.00 45.95 ? 43  ALA H CB  1 
ATOM   294  N N   . PRO A 1 41  ? 206.485 194.306 236.543 1.00 46.54 ? 44  PRO H N   1 
ATOM   295  C CA  . PRO A 1 41  ? 205.787 195.359 237.287 1.00 46.54 ? 44  PRO H CA  1 
ATOM   296  C C   . PRO A 1 41  ? 206.378 196.731 237.009 1.00 46.54 ? 44  PRO H C   1 
ATOM   297  O O   . PRO A 1 41  ? 207.470 197.055 237.485 1.00 46.54 ? 44  PRO H O   1 
ATOM   298  C CB  . PRO A 1 41  ? 205.978 194.942 238.749 1.00 46.54 ? 44  PRO H CB  1 
ATOM   299  C CG  . PRO A 1 41  ? 207.188 194.091 238.747 1.00 46.54 ? 44  PRO H CG  1 
ATOM   300  C CD  . PRO A 1 41  ? 207.208 193.383 237.432 1.00 46.54 ? 44  PRO H CD  1 
ATOM   301  N N   . GLY A 1 42  ? 205.659 197.542 236.240 1.00 48.24 ? 45  GLY H N   1 
ATOM   302  C CA  . GLY A 1 42  ? 206.135 198.846 235.834 1.00 48.24 ? 45  GLY H CA  1 
ATOM   303  C C   . GLY A 1 42  ? 206.771 198.916 234.463 1.00 48.24 ? 45  GLY H C   1 
ATOM   304  O O   . GLY A 1 42  ? 207.387 199.937 234.142 1.00 48.24 ? 45  GLY H O   1 
ATOM   305  N N   . LYS A 1 43  ? 206.650 197.871 233.649 1.00 46.48 ? 46  LYS H N   1 
ATOM   306  C CA  . LYS A 1 43  ? 207.229 197.846 232.314 1.00 46.48 ? 46  LYS H CA  1 
ATOM   307  C C   . LYS A 1 43  ? 206.197 197.313 231.329 1.00 46.48 ? 46  LYS H C   1 
ATOM   308  O O   . LYS A 1 43  ? 205.070 196.972 231.696 1.00 46.48 ? 46  LYS H O   1 
ATOM   309  C CB  . LYS A 1 43  ? 208.508 197.005 232.282 1.00 46.48 ? 46  LYS H CB  1 
ATOM   310  C CG  . LYS A 1 43  ? 209.757 197.780 232.651 1.00 46.48 ? 46  LYS H CG  1 
ATOM   311  C CD  . LYS A 1 43  ? 210.805 196.875 233.269 1.00 46.48 ? 46  LYS H CD  1 
ATOM   312  C CE  . LYS A 1 43  ? 211.941 197.683 233.871 1.00 46.48 ? 46  LYS H CE  1 
ATOM   313  N NZ  . LYS A 1 43  ? 211.508 198.428 235.085 1.00 46.48 ? 46  LYS H NZ  1 
ATOM   314  N N   . GLY A 1 44  ? 206.596 197.239 230.060 1.00 45.37 ? 47  GLY H N   1 
ATOM   315  C CA  . GLY A 1 44  ? 205.697 196.840 229.000 1.00 45.37 ? 47  GLY H CA  1 
ATOM   316  C C   . GLY A 1 44  ? 205.599 195.335 228.833 1.00 45.37 ? 47  GLY H C   1 
ATOM   317  O O   . GLY A 1 44  ? 206.194 194.550 229.567 1.00 45.37 ? 47  GLY H O   1 
ATOM   318  N N   . LEU A 1 45  ? 204.820 194.941 227.830 1.00 43.13 ? 48  LEU H N   1 
ATOM   319  C CA  . LEU A 1 45  ? 204.587 193.536 227.543 1.00 43.13 ? 48  LEU H CA  1 
ATOM   320  C C   . LEU A 1 45  ? 205.816 192.894 226.905 1.00 43.13 ? 48  LEU H C   1 
ATOM   321  O O   . LEU A 1 45  ? 206.656 193.558 226.294 1.00 43.13 ? 48  LEU H O   1 
ATOM   322  C CB  . LEU A 1 45  ? 203.382 193.377 226.618 1.00 43.13 ? 48  LEU H CB  1 
ATOM   323  C CG  . LEU A 1 45  ? 202.066 193.971 227.112 1.00 43.13 ? 48  LEU H CG  1 
ATOM   324  C CD1 . LEU A 1 45  ? 200.968 193.752 226.098 1.00 43.13 ? 48  LEU H CD1 1 
ATOM   325  C CD2 . LEU A 1 45  ? 201.696 193.354 228.432 1.00 43.13 ? 48  LEU H CD2 1 
ATOM   326  N N   . GLU A 1 46  ? 205.907 191.575 227.053 1.00 43.54 ? 49  GLU H N   1 
ATOM   327  C CA  . GLU A 1 46  ? 206.990 190.797 226.476 1.00 43.54 ? 49  GLU H CA  1 
ATOM   328  C C   . GLU A 1 46  ? 206.462 189.414 226.129 1.00 43.54 ? 49  GLU H C   1 
ATOM   329  O O   . GLU A 1 46  ? 205.710 188.819 226.903 1.00 43.54 ? 49  GLU H O   1 
ATOM   330  C CB  . GLU A 1 46  ? 208.176 190.690 227.435 1.00 43.54 ? 49  GLU H CB  1 
ATOM   331  C CG  . GLU A 1 46  ? 209.369 189.958 226.854 1.00 43.54 ? 49  GLU H CG  1 
ATOM   332  C CD  . GLU A 1 46  ? 210.545 189.922 227.803 1.00 43.54 ? 49  GLU H CD  1 
ATOM   333  O OE1 . GLU A 1 46  ? 210.416 190.443 228.929 1.00 43.54 ? 49  GLU H OE1 1 
ATOM   334  O OE2 . GLU A 1 46  ? 211.599 189.371 227.424 1.00 43.54 ? 49  GLU H OE2 1 
ATOM   335  N N   . TRP A 1 47  ? 206.863 188.911 224.966 1.00 42.93 ? 50  TRP H N   1 
ATOM   336  C CA  . TRP A 1 47  ? 206.391 187.630 224.459 1.00 42.93 ? 50  TRP H CA  1 
ATOM   337  C C   . TRP A 1 47  ? 207.396 186.536 224.798 1.00 42.93 ? 50  TRP H C   1 
ATOM   338  O O   . TRP A 1 47  ? 208.597 186.707 224.578 1.00 42.93 ? 50  TRP H O   1 
ATOM   339  C CB  . TRP A 1 47  ? 206.177 187.717 222.950 1.00 42.93 ? 50  TRP H CB  1 
ATOM   340  C CG  . TRP A 1 47  ? 205.979 186.415 222.286 1.00 42.93 ? 50  TRP H CG  1 
ATOM   341  C CD1 . TRP A 1 47  ? 204.815 185.727 222.164 1.00 42.93 ? 50  TRP H CD1 1 
ATOM   342  C CD2 . TRP A 1 47  ? 206.980 185.632 221.633 1.00 42.93 ? 50  TRP H CD2 1 
ATOM   343  N NE1 . TRP A 1 47  ? 205.026 184.560 221.477 1.00 42.93 ? 50  TRP H NE1 1 
ATOM   344  C CE2 . TRP A 1 47  ? 206.351 184.477 221.144 1.00 42.93 ? 50  TRP H CE2 1 
ATOM   345  C CE3 . TRP A 1 47  ? 208.351 185.794 221.421 1.00 42.93 ? 50  TRP H CE3 1 
ATOM   346  C CZ2 . TRP A 1 47  ? 207.041 183.490 220.453 1.00 42.93 ? 50  TRP H CZ2 1 
ATOM   347  C CZ3 . TRP A 1 47  ? 209.035 184.813 220.735 1.00 42.93 ? 50  TRP H CZ3 1 
ATOM   348  C CH2 . TRP A 1 47  ? 208.379 183.676 220.258 1.00 42.93 ? 50  TRP H CH2 1 
ATOM   349  N N   . VAL A 1 48  ? 206.906 185.413 225.323 1.00 42.81 ? 51  VAL H N   1 
ATOM   350  C CA  . VAL A 1 48  ? 207.785 184.384 225.866 1.00 42.81 ? 51  VAL H CA  1 
ATOM   351  C C   . VAL A 1 48  ? 207.953 183.215 224.904 1.00 42.81 ? 51  VAL H C   1 
ATOM   352  O O   . VAL A 1 48  ? 209.060 182.954 224.421 1.00 42.81 ? 51  VAL H O   1 
ATOM   353  C CB  . VAL A 1 48  ? 207.268 183.884 227.223 1.00 42.81 ? 51  VAL H CB  1 
ATOM   354  C CG1 . VAL A 1 48  ? 208.321 183.039 227.905 1.00 42.81 ? 51  VAL H CG1 1 
ATOM   355  C CG2 . VAL A 1 48  ? 206.880 185.057 228.100 1.00 42.81 ? 51  VAL H CG2 1 
ATOM   356  N N   . ALA A 1 49  ? 206.869 182.500 224.620 1.00 43.42 ? 52  ALA H N   1 
ATOM   357  C CA  . ALA A 1 49  ? 206.942 181.302 223.796 1.00 43.42 ? 52  ALA H CA  1 
ATOM   358  C C   . ALA A 1 49  ? 205.576 181.040 223.181 1.00 43.42 ? 52  ALA H C   1 
ATOM   359  O O   . ALA A 1 49  ? 204.614 181.772 223.430 1.00 43.42 ? 52  ALA H O   1 
ATOM   360  C CB  . ALA A 1 49  ? 207.419 180.105 224.617 1.00 43.42 ? 52  ALA H CB  1 
ATOM   361  N N   . TYR A 1 50  ? 205.493 179.992 222.363 1.00 43.58 ? 53  TYR H N   1 
ATOM   362  C CA  . TYR A 1 50  ? 204.199 179.556 221.856 1.00 43.58 ? 53  TYR H CA  1 
ATOM   363  C C   . TYR A 1 50  ? 204.292 178.103 221.418 1.00 43.58 ? 53  TYR H C   1 
ATOM   364  O O   . TYR A 1 50  ? 205.385 177.568 221.221 1.00 43.58 ? 53  TYR H O   1 
ATOM   365  C CB  . TYR A 1 50  ? 203.711 180.395 220.674 1.00 43.58 ? 53  TYR H CB  1 
ATOM   366  C CG  . TYR A 1 50  ? 204.431 180.118 219.378 1.00 43.58 ? 53  TYR H CG  1 
ATOM   367  C CD1 . TYR A 1 50  ? 203.780 179.479 218.337 1.00 43.58 ? 53  TYR H CD1 1 
ATOM   368  C CD2 . TYR A 1 50  ? 205.738 180.514 219.184 1.00 43.58 ? 53  TYR H CD2 1 
ATOM   369  C CE1 . TYR A 1 50  ? 204.413 179.220 217.152 1.00 43.58 ? 53  TYR H CE1 1 
ATOM   370  C CE2 . TYR A 1 50  ? 206.379 180.264 217.993 1.00 43.58 ? 53  TYR H CE2 1 
ATOM   371  C CZ  . TYR A 1 50  ? 205.711 179.616 216.983 1.00 43.58 ? 53  TYR H CZ  1 
ATOM   372  O OH  . TYR A 1 50  ? 206.350 179.362 215.794 1.00 43.58 ? 53  TYR H OH  1 
ATOM   373  N N   . ILE A 1 51  ? 203.125 177.475 221.268 1.00 44.47 ? 54  ILE H N   1 
ATOM   374  C CA  . ILE A 1 51  ? 203.007 176.149 220.679 1.00 44.47 ? 54  ILE H CA  1 
ATOM   375  C C   . ILE A 1 51  ? 201.828 176.158 219.718 1.00 44.47 ? 54  ILE H C   1 
ATOM   376  O O   . ILE A 1 51  ? 200.943 177.012 219.791 1.00 44.47 ? 54  ILE H O   1 
ATOM   377  C CB  . ILE A 1 51  ? 202.828 175.039 221.733 1.00 44.47 ? 54  ILE H CB  1 
ATOM   378  C CG1 . ILE A 1 51  ? 203.329 173.708 221.185 1.00 44.47 ? 54  ILE H CG1 1 
ATOM   379  C CG2 . ILE A 1 51  ? 201.373 174.918 222.132 1.00 44.47 ? 54  ILE H CG2 1 
ATOM   380  C CD1 . ILE A 1 51  ? 203.212 172.573 222.157 1.00 44.47 ? 54  ILE H CD1 1 
ATOM   381  N N   . SER A 1 52  ? 201.830 175.196 218.801 1.00 48.62 ? 55  SER H N   1 
ATOM   382  C CA  . SER A 1 52  ? 200.796 175.071 217.781 1.00 48.62 ? 55  SER H CA  1 
ATOM   383  C C   . SER A 1 52  ? 199.838 173.919 218.024 1.00 48.62 ? 55  SER H C   1 
ATOM   384  O O   . SER A 1 52  ? 198.652 174.037 217.707 1.00 48.62 ? 55  SER H O   1 
ATOM   385  C CB  . SER A 1 52  ? 201.438 174.899 216.402 1.00 48.62 ? 55  SER H CB  1 
ATOM   386  O OG  . SER A 1 52  ? 202.227 173.725 216.361 1.00 48.62 ? 55  SER H OG  1 
ATOM   387  N N   . SER A 1 53  ? 200.336 172.795 218.542 1.00 52.32 ? 56  SER H N   1 
ATOM   388  C CA  . SER A 1 53  ? 199.528 171.641 218.928 1.00 52.32 ? 56  SER H CA  1 
ATOM   389  C C   . SER A 1 53  ? 198.921 170.930 217.725 1.00 52.32 ? 56  SER H C   1 
ATOM   390  O O   . SER A 1 53  ? 198.269 169.893 217.878 1.00 52.32 ? 56  SER H O   1 
ATOM   391  C CB  . SER A 1 53  ? 198.425 172.051 219.908 1.00 52.32 ? 56  SER H CB  1 
ATOM   392  O OG  . SER A 1 53  ? 197.756 170.914 220.422 1.00 52.32 ? 56  SER H OG  1 
ATOM   393  N N   . SER A 1 54  ? 199.130 171.470 216.528 1.00 51.26 ? 57  SER H N   1 
ATOM   394  C CA  . SER A 1 54  ? 198.723 170.814 215.292 1.00 51.26 ? 57  SER H CA  1 
ATOM   395  C C   . SER A 1 54  ? 199.887 170.139 214.586 1.00 51.26 ? 57  SER H C   1 
ATOM   396  O O   . SER A 1 54  ? 199.720 169.058 214.015 1.00 51.26 ? 57  SER H O   1 
ATOM   397  C CB  . SER A 1 54  ? 198.070 171.823 214.345 1.00 51.26 ? 57  SER H CB  1 
ATOM   398  O OG  . SER A 1 54  ? 197.658 171.196 213.144 1.00 51.26 ? 57  SER H OG  1 
ATOM   399  N N   . SER A 1 55  ? 201.062 170.760 214.615 1.00 51.38 ? 58  SER H N   1 
ATOM   400  C CA  . SER A 1 55  ? 202.281 170.161 214.101 1.00 51.38 ? 58  SER H CA  1 
ATOM   401  C C   . SER A 1 55  ? 203.355 170.017 215.167 1.00 51.38 ? 58  SER H C   1 
ATOM   402  O O   . SER A 1 55  ? 204.451 169.537 214.858 1.00 51.38 ? 58  SER H O   1 
ATOM   403  C CB  . SER A 1 55  ? 202.831 170.987 212.931 1.00 51.38 ? 58  SER H CB  1 
ATOM   404  O OG  . SER A 1 55  ? 203.237 172.270 213.369 1.00 51.38 ? 58  SER H OG  1 
ATOM   405  N N   . GLY A 1 56  ? 203.078 170.417 216.404 1.00 50.10 ? 59  GLY H N   1 
ATOM   406  C CA  . GLY A 1 56  ? 204.059 170.334 217.463 1.00 50.10 ? 59  GLY H CA  1 
ATOM   407  C C   . GLY A 1 56  ? 205.109 171.418 217.449 1.00 50.10 ? 59  GLY H C   1 
ATOM   408  O O   . GLY A 1 56  ? 206.083 171.322 218.205 1.00 50.10 ? 59  GLY H O   1 
ATOM   409  N N   . SER A 1 57  ? 204.949 172.442 216.618 1.00 48.43 ? 60  SER H N   1 
ATOM   410  C CA  . SER A 1 57  ? 205.985 173.453 216.466 1.00 48.43 ? 60  SER H CA  1 
ATOM   411  C C   . SER A 1 57  ? 206.012 174.406 217.652 1.00 48.43 ? 60  SER H C   1 
ATOM   412  O O   . SER A 1 57  ? 204.975 174.885 218.113 1.00 48.43 ? 60  SER H O   1 
ATOM   413  C CB  . SER A 1 57  ? 205.772 174.230 215.175 1.00 48.43 ? 60  SER H CB  1 
ATOM   414  O OG  . SER A 1 57  ? 206.006 173.390 214.064 1.00 48.43 ? 60  SER H OG  1 
ATOM   415  N N   . THR A 1 58  ? 207.218 174.680 218.144 1.00 44.47 ? 61  THR H N   1 
ATOM   416  C CA  . THR A 1 58  ? 207.421 175.569 219.274 1.00 44.47 ? 61  THR H CA  1 
ATOM   417  C C   . THR A 1 58  ? 208.557 176.532 218.966 1.00 44.47 ? 61  THR H C   1 
ATOM   418  O O   . THR A 1 58  ? 209.413 176.267 218.120 1.00 44.47 ? 61  THR H O   1 
ATOM   419  C CB  . THR A 1 58  ? 207.754 174.802 220.558 1.00 44.47 ? 61  THR H CB  1 
ATOM   420  O OG1 . THR A 1 58  ? 209.171 174.608 220.637 1.00 44.47 ? 61  THR H OG1 1 
ATOM   421  C CG2 . THR A 1 58  ? 207.064 173.450 220.587 1.00 44.47 ? 61  THR H CG2 1 
ATOM   422  N N   . SER A 1 59  ? 208.551 177.662 219.667 1.00 43.87 ? 62  SER H N   1 
ATOM   423  C CA  . SER A 1 59  ? 209.662 178.601 219.632 1.00 43.87 ? 62  SER H CA  1 
ATOM   424  C C   . SER A 1 59  ? 209.646 179.398 220.924 1.00 43.87 ? 62  SER H C   1 
ATOM   425  O O   . SER A 1 59  ? 208.623 179.488 221.606 1.00 43.87 ? 62  SER H O   1 
ATOM   426  C CB  . SER A 1 59  ? 209.595 179.528 218.417 1.00 43.87 ? 62  SER H CB  1 
ATOM   427  O OG  . SER A 1 59  ? 210.828 180.187 218.213 1.00 43.87 ? 62  SER H OG  1 
ATOM   428  N N   . TYR A 1 60  ? 210.791 179.983 221.247 1.00 43.11 ? 63  TYR H N   1 
ATOM   429  C CA  . TYR A 1 60  ? 210.981 180.618 222.538 1.00 43.11 ? 63  TYR H CA  1 
ATOM   430  C C   . TYR A 1 60  ? 211.621 181.981 222.348 1.00 43.11 ? 63  TYR H C   1 
ATOM   431  O O   . TYR A 1 60  ? 212.264 182.252 221.332 1.00 43.11 ? 63  TYR H O   1 
ATOM   432  C CB  . TYR A 1 60  ? 211.844 179.750 223.449 1.00 43.11 ? 63  TYR H CB  1 
ATOM   433  C CG  . TYR A 1 60  ? 211.304 178.359 223.625 1.00 43.11 ? 63  TYR H CG  1 
ATOM   434  C CD1 . TYR A 1 60  ? 210.253 178.111 224.485 1.00 43.11 ? 63  TYR H CD1 1 
ATOM   435  C CD2 . TYR A 1 60  ? 211.838 177.296 222.923 1.00 43.11 ? 63  TYR H CD2 1 
ATOM   436  C CE1 . TYR A 1 60  ? 209.756 176.847 224.652 1.00 43.11 ? 63  TYR H CE1 1 
ATOM   437  C CE2 . TYR A 1 60  ? 211.345 176.022 223.084 1.00 43.11 ? 63  TYR H CE2 1 
ATOM   438  C CZ  . TYR A 1 60  ? 210.300 175.806 223.949 1.00 43.11 ? 63  TYR H CZ  1 
ATOM   439  O OH  . TYR A 1 60  ? 209.800 174.538 224.114 1.00 43.11 ? 63  TYR H OH  1 
ATOM   440  N N   . ALA A 1 61  ? 211.433 182.843 223.339 1.00 45.52 ? 64  ALA H N   1 
ATOM   441  C CA  . ALA A 1 61  ? 212.085 184.140 223.324 1.00 45.52 ? 64  ALA H CA  1 
ATOM   442  C C   . ALA A 1 61  ? 213.587 183.977 223.512 1.00 45.52 ? 64  ALA H C   1 
ATOM   443  O O   . ALA A 1 61  ? 214.064 182.984 224.067 1.00 45.52 ? 64  ALA H O   1 
ATOM   444  C CB  . ALA A 1 61  ? 211.514 185.040 224.417 1.00 45.52 ? 64  ALA H CB  1 
ATOM   445  N N   . ASP A 1 62  ? 214.339 184.969 223.036 1.00 49.99 ? 65  ASP H N   1 
ATOM   446  C CA  . ASP A 1 62  ? 215.791 184.913 223.133 1.00 49.99 ? 65  ASP H CA  1 
ATOM   447  C C   . ASP A 1 62  ? 216.293 185.035 224.565 1.00 49.99 ? 65  ASP H C   1 
ATOM   448  O O   . ASP A 1 62  ? 217.481 184.798 224.806 1.00 49.99 ? 65  ASP H O   1 
ATOM   449  C CB  . ASP A 1 62  ? 216.416 186.007 222.269 1.00 49.99 ? 65  ASP H CB  1 
ATOM   450  C CG  . ASP A 1 62  ? 215.835 187.375 222.553 1.00 49.99 ? 65  ASP H CG  1 
ATOM   451  O OD1 . ASP A 1 62  ? 214.852 187.459 223.319 1.00 49.99 ? 65  ASP H OD1 1 
ATOM   452  O OD2 . ASP A 1 62  ? 216.360 188.370 222.009 1.00 49.99 ? 65  ASP H OD2 1 
ATOM   453  N N   . SER A 1 63  ? 215.429 185.396 225.512 1.00 47.37 ? 66  SER H N   1 
ATOM   454  C CA  . SER A 1 63  ? 215.824 185.495 226.909 1.00 47.37 ? 66  SER H CA  1 
ATOM   455  C C   . SER A 1 63  ? 215.626 184.196 227.674 1.00 47.37 ? 66  SER H C   1 
ATOM   456  O O   . SER A 1 63  ? 216.338 183.948 228.652 1.00 47.37 ? 66  SER H O   1 
ATOM   457  C CB  . SER A 1 63  ? 215.039 186.611 227.599 1.00 47.37 ? 66  SER H CB  1 
ATOM   458  O OG  . SER A 1 63  ? 213.654 186.316 227.624 1.00 47.37 ? 66  SER H OG  1 
ATOM   459  N N   . VAL A 1 64  ? 214.677 183.364 227.257 1.00 47.02 ? 67  VAL H N   1 
ATOM   460  C CA  . VAL A 1 64  ? 214.404 182.103 227.935 1.00 47.02 ? 67  VAL H CA  1 
ATOM   461  C C   . VAL A 1 64  ? 214.496 180.965 226.927 1.00 47.02 ? 67  VAL H C   1 
ATOM   462  O O   . VAL A 1 64  ? 213.804 179.950 227.055 1.00 47.02 ? 67  VAL H O   1 
ATOM   463  C CB  . VAL A 1 64  ? 213.030 182.127 228.628 1.00 47.02 ? 67  VAL H CB  1 
ATOM   464  C CG1 . VAL A 1 64  ? 213.039 183.117 229.782 1.00 47.02 ? 67  VAL H CG1 1 
ATOM   465  C CG2 . VAL A 1 64  ? 211.940 182.477 227.641 1.00 47.02 ? 67  VAL H CG2 1 
ATOM   466  N N   . LYS A 1 65  ? 215.348 181.135 225.912 1.00 47.41 ? 68  LYS H N   1 
ATOM   467  C CA  . LYS A 1 65  ? 215.464 180.139 224.851 1.00 47.41 ? 68  LYS H CA  1 
ATOM   468  C C   . LYS A 1 65  ? 215.867 178.774 225.395 1.00 47.41 ? 68  LYS H C   1 
ATOM   469  O O   . LYS A 1 65  ? 215.227 177.761 225.094 1.00 47.41 ? 68  LYS H O   1 
ATOM   470  C CB  . LYS A 1 65  ? 216.467 180.613 223.803 1.00 47.41 ? 68  LYS H CB  1 
ATOM   471  C CG  . LYS A 1 65  ? 216.689 179.626 222.676 1.00 47.41 ? 68  LYS H CG  1 
ATOM   472  C CD  . LYS A 1 65  ? 215.573 179.701 221.651 1.00 47.41 ? 68  LYS H CD  1 
ATOM   473  C CE  . LYS A 1 65  ? 215.306 181.135 221.224 1.00 47.41 ? 68  LYS H CE  1 
ATOM   474  N NZ  . LYS A 1 65  ? 216.503 181.760 220.596 1.00 47.41 ? 68  LYS H NZ  1 
ATOM   475  N N   . GLY A 1 66  ? 216.927 178.724 226.196 1.00 50.07 ? 69  GLY H N   1 
ATOM   476  C CA  . GLY A 1 66  ? 217.426 177.452 226.676 1.00 50.07 ? 69  GLY H CA  1 
ATOM   477  C C   . GLY A 1 66  ? 216.800 176.913 227.942 1.00 50.07 ? 69  GLY H C   1 
ATOM   478  O O   . GLY A 1 66  ? 217.073 175.767 228.312 1.00 50.07 ? 69  GLY H O   1 
ATOM   479  N N   . ARG A 1 67  ? 215.953 177.693 228.614 1.00 51.67 ? 70  ARG H N   1 
ATOM   480  C CA  . ARG A 1 67  ? 215.452 177.333 229.936 1.00 51.67 ? 70  ARG H CA  1 
ATOM   481  C C   . ARG A 1 67  ? 214.042 176.758 229.907 1.00 51.67 ? 70  ARG H C   1 
ATOM   482  O O   . ARG A 1 67  ? 213.809 175.669 230.436 1.00 51.67 ? 70  ARG H O   1 
ATOM   483  C CB  . ARG A 1 67  ? 215.493 178.556 230.861 1.00 51.67 ? 70  ARG H CB  1 
ATOM   484  C CG  . ARG A 1 67  ? 216.823 179.278 230.876 1.00 51.67 ? 70  ARG H CG  1 
ATOM   485  C CD  . ARG A 1 67  ? 217.000 180.070 232.156 1.00 51.67 ? 70  ARG H CD  1 
ATOM   486  N NE  . ARG A 1 67  ? 216.761 181.492 231.949 1.00 51.67 ? 70  ARG H NE  1 
ATOM   487  C CZ  . ARG A 1 67  ? 215.771 182.176 232.505 1.00 51.67 ? 70  ARG H CZ  1 
ATOM   488  N NH1 . ARG A 1 67  ? 214.901 181.598 233.316 1.00 51.67 ? 70  ARG H NH1 1 
ATOM   489  N NH2 . ARG A 1 67  ? 215.652 183.474 232.243 1.00 51.67 ? 70  ARG H NH2 1 
ATOM   490  N N   . PHE A 1 68  ? 213.094 177.464 229.302 1.00 50.08 ? 71  PHE H N   1 
ATOM   491  C CA  . PHE A 1 68  ? 211.701 177.056 229.379 1.00 50.08 ? 71  PHE H CA  1 
ATOM   492  C C   . PHE A 1 68  ? 211.398 175.956 228.366 1.00 50.08 ? 71  PHE H C   1 
ATOM   493  O O   . PHE A 1 68  ? 212.132 175.742 227.398 1.00 50.08 ? 71  PHE H O   1 
ATOM   494  C CB  . PHE A 1 68  ? 210.776 178.248 229.133 1.00 50.08 ? 71  PHE H CB  1 
ATOM   495  C CG  . PHE A 1 68  ? 210.801 179.279 230.228 1.00 50.08 ? 71  PHE H CG  1 
ATOM   496  C CD1 . PHE A 1 68  ? 211.507 179.062 231.393 1.00 50.08 ? 71  PHE H CD1 1 
ATOM   497  C CD2 . PHE A 1 68  ? 210.111 180.467 230.084 1.00 50.08 ? 71  PHE H CD2 1 
ATOM   498  C CE1 . PHE A 1 68  ? 211.528 180.011 232.386 1.00 50.08 ? 71  PHE H CE1 1 
ATOM   499  C CE2 . PHE A 1 68  ? 210.124 181.412 231.071 1.00 50.08 ? 71  PHE H CE2 1 
ATOM   500  C CZ  . PHE A 1 68  ? 210.833 181.188 232.225 1.00 50.08 ? 71  PHE H CZ  1 
ATOM   501  N N   . THR A 1 69  ? 210.292 175.255 228.604 1.00 50.70 ? 72  THR H N   1 
ATOM   502  C CA  . THR A 1 69  ? 209.815 174.208 227.711 1.00 50.70 ? 72  THR H CA  1 
ATOM   503  C C   . THR A 1 69  ? 208.298 174.270 227.666 1.00 50.70 ? 72  THR H C   1 
ATOM   504  O O   . THR A 1 69  ? 207.653 174.398 228.711 1.00 50.70 ? 72  THR H O   1 
ATOM   505  C CB  . THR A 1 69  ? 210.279 172.824 228.175 1.00 50.70 ? 72  THR H CB  1 
ATOM   506  O OG1 . THR A 1 69  ? 211.711 172.782 228.189 1.00 50.70 ? 72  THR H OG1 1 
ATOM   507  C CG2 . THR A 1 69  ? 209.757 171.743 227.248 1.00 50.70 ? 72  THR H CG2 1 
ATOM   508  N N   . ILE A 1 70  ? 207.729 174.182 226.466 1.00 49.35 ? 73  ILE H N   1 
ATOM   509  C CA  . ILE A 1 70  ? 206.294 174.336 226.262 1.00 49.35 ? 73  ILE H CA  1 
ATOM   510  C C   . ILE A 1 70  ? 205.749 173.073 225.610 1.00 49.35 ? 73  ILE H C   1 
ATOM   511  O O   . ILE A 1 70  ? 206.371 172.517 224.699 1.00 49.35 ? 73  ILE H O   1 
ATOM   512  C CB  . ILE A 1 70  ? 205.971 175.583 225.420 1.00 49.35 ? 73  ILE H CB  1 
ATOM   513  C CG1 . ILE A 1 70  ? 204.459 175.763 225.293 1.00 49.35 ? 73  ILE H CG1 1 
ATOM   514  C CG2 . ILE A 1 70  ? 206.625 175.509 224.058 1.00 49.35 ? 73  ILE H CG2 1 
ATOM   515  C CD1 . ILE A 1 70  ? 204.055 177.114 224.763 1.00 49.35 ? 73  ILE H CD1 1 
ATOM   516  N N   . SER A 1 71  ? 204.602 172.610 226.100 1.00 52.79 ? 74  SER H N   1 
ATOM   517  C CA  . SER A 1 71  ? 203.954 171.418 225.575 1.00 52.79 ? 74  SER H CA  1 
ATOM   518  C C   . SER A 1 71  ? 202.470 171.503 225.893 1.00 52.79 ? 74  SER H C   1 
ATOM   519  O O   . SER A 1 71  ? 202.046 172.284 226.748 1.00 52.79 ? 74  SER H O   1 
ATOM   520  C CB  . SER A 1 71  ? 204.564 170.141 226.161 1.00 52.79 ? 74  SER H CB  1 
ATOM   521  O OG  . SER A 1 71  ? 204.354 170.072 227.559 1.00 52.79 ? 74  SER H OG  1 
ATOM   522  N N   . ALA A 1 72  ? 201.684 170.689 225.195 1.00 54.57 ? 75  ALA H N   1 
ATOM   523  C CA  . ALA A 1 72  ? 200.238 170.725 225.331 1.00 54.57 ? 75  ALA H CA  1 
ATOM   524  C C   . ALA A 1 72  ? 199.664 169.333 225.122 1.00 54.57 ? 75  ALA H C   1 
ATOM   525  O O   . ALA A 1 72  ? 200.326 168.436 224.595 1.00 54.57 ? 75  ALA H O   1 
ATOM   526  C CB  . ALA A 1 72  ? 199.605 171.708 224.339 1.00 54.57 ? 75  ALA H CB  1 
ATOM   527  N N   . ASP A 1 73  ? 198.416 169.163 225.550 1.00 59.74 ? 76  ASP H N   1 
ATOM   528  C CA  . ASP A 1 73  ? 197.670 167.934 225.335 1.00 59.74 ? 76  ASP H CA  1 
ATOM   529  C C   . ASP A 1 73  ? 196.274 168.274 224.835 1.00 59.74 ? 76  ASP H C   1 
ATOM   530  O O   . ASP A 1 73  ? 195.744 169.353 225.108 1.00 59.74 ? 76  ASP H O   1 
ATOM   531  C CB  . ASP A 1 73  ? 197.586 167.085 226.612 1.00 59.74 ? 76  ASP H CB  1 
ATOM   532  C CG  . ASP A 1 73  ? 197.016 167.849 227.790 1.00 59.74 ? 76  ASP H CG  1 
ATOM   533  O OD1 . ASP A 1 73  ? 196.815 169.075 227.672 1.00 59.74 ? 76  ASP H OD1 1 
ATOM   534  O OD2 . ASP A 1 73  ? 196.766 167.219 228.839 1.00 59.74 ? 76  ASP H OD2 1 
ATOM   535  N N   . THR A 1 74  ? 195.683 167.339 224.094 1.00 61.37 ? 77  THR H N   1 
ATOM   536  C CA  . THR A 1 74  ? 194.403 167.581 223.443 1.00 61.37 ? 77  THR H CA  1 
ATOM   537  C C   . THR A 1 74  ? 193.217 167.141 224.290 1.00 61.37 ? 77  THR H C   1 
ATOM   538  O O   . THR A 1 74  ? 192.189 167.827 224.316 1.00 61.37 ? 77  THR H O   1 
ATOM   539  C CB  . THR A 1 74  ? 194.360 166.868 222.090 1.00 61.37 ? 77  THR H CB  1 
ATOM   540  O OG1 . THR A 1 74  ? 195.489 167.268 221.303 1.00 61.37 ? 77  THR H OG1 1 
ATOM   541  C CG2 . THR A 1 74  ? 193.078 167.203 221.346 1.00 61.37 ? 77  THR H CG2 1 
ATOM   542  N N   . SER A 1 75  ? 193.338 166.010 224.988 1.00 61.53 ? 78  SER H N   1 
ATOM   543  C CA  . SER A 1 75  ? 192.211 165.496 225.760 1.00 61.53 ? 78  SER H CA  1 
ATOM   544  C C   . SER A 1 75  ? 191.814 166.456 226.876 1.00 61.53 ? 78  SER H C   1 
ATOM   545  O O   . SER A 1 75  ? 190.622 166.655 227.138 1.00 61.53 ? 78  SER H O   1 
ATOM   546  C CB  . SER A 1 75  ? 192.553 164.120 226.330 1.00 61.53 ? 78  SER H CB  1 
ATOM   547  O OG  . SER A 1 75  ? 193.628 164.203 227.250 1.00 61.53 ? 78  SER H OG  1 
ATOM   548  N N   . LYS A 1 76  ? 192.796 167.059 227.545 1.00 59.12 ? 79  LYS H N   1 
ATOM   549  C CA  . LYS A 1 76  ? 192.532 167.931 228.679 1.00 59.12 ? 79  LYS H CA  1 
ATOM   550  C C   . LYS A 1 76  ? 192.413 169.403 228.305 1.00 59.12 ? 79  LYS H C   1 
ATOM   551  O O   . LYS A 1 76  ? 191.939 170.192 229.130 1.00 59.12 ? 79  LYS H O   1 
ATOM   552  C CB  . LYS A 1 76  ? 193.630 167.766 229.735 1.00 59.12 ? 79  LYS H CB  1 
ATOM   553  C CG  . LYS A 1 76  ? 193.630 166.409 230.416 1.00 59.12 ? 79  LYS H CG  1 
ATOM   554  C CD  . LYS A 1 76  ? 194.737 166.310 231.452 1.00 59.12 ? 79  LYS H CD  1 
ATOM   555  C CE  . LYS A 1 76  ? 194.710 164.965 232.160 1.00 59.12 ? 79  LYS H CE  1 
ATOM   556  N NZ  . LYS A 1 76  ? 195.800 164.846 233.167 1.00 59.12 ? 79  LYS H NZ  1 
ATOM   557  N N   . ASN A 1 77  ? 192.832 169.789 227.099 1.00 56.96 ? 80  ASN H N   1 
ATOM   558  C CA  . ASN A 1 77  ? 192.729 171.172 226.625 1.00 56.96 ? 80  ASN H CA  1 
ATOM   559  C C   . ASN A 1 77  ? 193.507 172.137 227.520 1.00 56.96 ? 80  ASN H C   1 
ATOM   560  O O   . ASN A 1 77  ? 192.975 173.138 228.003 1.00 56.96 ? 80  ASN H O   1 
ATOM   561  C CB  . ASN A 1 77  ? 191.266 171.598 226.508 1.00 56.96 ? 80  ASN H CB  1 
ATOM   562  C CG  . ASN A 1 77  ? 190.718 171.418 225.114 1.00 56.96 ? 80  ASN H CG  1 
ATOM   563  O OD1 . ASN A 1 77  ? 190.728 172.346 224.307 1.00 56.96 ? 80  ASN H OD1 1 
ATOM   564  N ND2 . ASN A 1 77  ? 190.232 170.219 224.819 1.00 56.96 ? 80  ASN H ND2 1 
ATOM   565  N N   . THR A 1 78  ? 194.787 171.836 227.734 1.00 55.48 ? 81  THR H N   1 
ATOM   566  C CA  . THR A 1 78  ? 195.636 172.637 228.604 1.00 55.48 ? 81  THR H CA  1 
ATOM   567  C C   . THR A 1 78  ? 197.030 172.748 228.011 1.00 55.48 ? 81  THR H C   1 
ATOM   568  O O   . THR A 1 78  ? 197.571 171.768 227.496 1.00 55.48 ? 81  THR H O   1 
ATOM   569  C CB  . THR A 1 78  ? 195.733 172.027 230.006 1.00 55.48 ? 81  THR H CB  1 
ATOM   570  O OG1 . THR A 1 78  ? 195.738 170.598 229.905 1.00 55.48 ? 81  THR H OG1 1 
ATOM   571  C CG2 . THR A 1 78  ? 194.556 172.456 230.857 1.00 55.48 ? 81  THR H CG2 1 
ATOM   572  N N   . ALA A 1 79  ? 197.613 173.938 228.096 1.00 53.36 ? 82  ALA H N   1 
ATOM   573  C CA  . ALA A 1 79  ? 198.973 174.182 227.638 1.00 53.36 ? 82  ALA H CA  1 
ATOM   574  C C   . ALA A 1 79  ? 199.870 174.404 228.843 1.00 53.36 ? 82  ALA H C   1 
ATOM   575  O O   . ALA A 1 79  ? 199.541 175.200 229.729 1.00 53.36 ? 82  ALA H O   1 
ATOM   576  C CB  . ALA A 1 79  ? 199.038 175.391 226.706 1.00 53.36 ? 82  ALA H CB  1 
ATOM   577  N N   . TYR A 1 80  ? 200.998 173.708 228.873 1.00 52.11 ? 83  TYR H N   1 
ATOM   578  C CA  . TYR A 1 80  ? 201.917 173.758 229.996 1.00 52.11 ? 83  TYR H CA  1 
ATOM   579  C C   . TYR A 1 80  ? 203.212 174.431 229.574 1.00 52.11 ? 83  TYR H C   1 
ATOM   580  O O   . TYR A 1 80  ? 203.785 174.098 228.533 1.00 52.11 ? 83  TYR H O   1 
ATOM   581  C CB  . TYR A 1 80  ? 202.208 172.352 230.525 1.00 52.11 ? 83  TYR H CB  1 
ATOM   582  C CG  . TYR A 1 80  ? 200.974 171.569 230.902 1.00 52.11 ? 83  TYR H CG  1 
ATOM   583  C CD1 . TYR A 1 80  ? 199.961 172.153 231.641 1.00 52.11 ? 83  TYR H CD1 1 
ATOM   584  C CD2 . TYR A 1 80  ? 200.824 170.249 230.519 1.00 52.11 ? 83  TYR H CD2 1 
ATOM   585  C CE1 . TYR A 1 80  ? 198.836 171.444 231.991 1.00 52.11 ? 83  TYR H CE1 1 
ATOM   586  C CE2 . TYR A 1 80  ? 199.702 169.532 230.861 1.00 52.11 ? 83  TYR H CE2 1 
ATOM   587  C CZ  . TYR A 1 80  ? 198.710 170.133 231.597 1.00 52.11 ? 83  TYR H CZ  1 
ATOM   588  O OH  . TYR A 1 80  ? 197.586 169.423 231.944 1.00 52.11 ? 83  TYR H OH  1 
ATOM   589  N N   . LEU A 1 81  ? 203.672 175.378 230.386 1.00 48.96 ? 84  LEU H N   1 
ATOM   590  C CA  . LEU A 1 81  ? 204.935 176.071 230.151 1.00 48.96 ? 84  LEU H CA  1 
ATOM   591  C C   . LEU A 1 81  ? 205.854 175.789 231.332 1.00 48.96 ? 84  LEU H C   1 
ATOM   592  O O   . LEU A 1 81  ? 205.784 176.469 232.360 1.00 48.96 ? 84  LEU H O   1 
ATOM   593  C CB  . LEU A 1 81  ? 204.721 177.566 229.961 1.00 48.96 ? 84  LEU H CB  1 
ATOM   594  C CG  . LEU A 1 81  ? 205.997 178.331 229.609 1.00 48.96 ? 84  LEU H CG  1 
ATOM   595  C CD1 . LEU A 1 81  ? 206.573 177.832 228.301 1.00 48.96 ? 84  LEU H CD1 1 
ATOM   596  C CD2 . LEU A 1 81  ? 205.741 179.823 229.543 1.00 48.96 ? 84  LEU H CD2 1 
ATOM   597  N N   . GLN A 1 82  ? 206.711 174.785 231.185 1.00 50.54 ? 85  GLN H N   1 
ATOM   598  C CA  . GLN A 1 82  ? 207.653 174.450 232.240 1.00 50.54 ? 85  GLN H CA  1 
ATOM   599  C C   . GLN A 1 82  ? 208.688 175.554 232.398 1.00 50.54 ? 85  GLN H C   1 
ATOM   600  O O   . GLN A 1 82  ? 209.201 176.094 231.415 1.00 50.54 ? 85  GLN H O   1 
ATOM   601  C CB  . GLN A 1 82  ? 208.344 173.125 231.930 1.00 50.54 ? 85  GLN H CB  1 
ATOM   602  C CG  . GLN A 1 82  ? 209.278 172.648 233.015 1.00 50.54 ? 85  GLN H CG  1 
ATOM   603  C CD  . GLN A 1 82  ? 208.743 171.438 233.741 1.00 50.54 ? 85  GLN H CD  1 
ATOM   604  O OE1 . GLN A 1 82  ? 207.635 170.981 233.471 1.00 50.54 ? 85  GLN H OE1 1 
ATOM   605  N NE2 . GLN A 1 82  ? 209.528 170.909 234.670 1.00 50.54 ? 85  GLN H NE2 1 
ATOM   606  N N   . MET A 1 83  ? 208.994 175.889 233.646 1.00 52.83 ? 86  MET H N   1 
ATOM   607  C CA  . MET A 1 83  ? 210.002 176.886 233.975 1.00 52.83 ? 86  MET H CA  1 
ATOM   608  C C   . MET A 1 83  ? 211.185 176.189 234.633 1.00 52.83 ? 86  MET H C   1 
ATOM   609  O O   . MET A 1 83  ? 211.019 175.504 235.647 1.00 52.83 ? 86  MET H O   1 
ATOM   610  C CB  . MET A 1 83  ? 209.432 177.953 234.906 1.00 52.83 ? 86  MET H CB  1 
ATOM   611  C CG  . MET A 1 83  ? 208.740 179.091 234.196 1.00 52.83 ? 86  MET H CG  1 
ATOM   612  S SD  . MET A 1 83  ? 207.364 179.742 235.148 1.00 52.83 ? 86  MET H SD  1 
ATOM   613  C CE  . MET A 1 83  ? 206.862 181.098 234.102 1.00 52.83 ? 86  MET H CE  1 
ATOM   614  N N   . ASN A 1 84  ? 212.368 176.359 234.055 1.00 54.06 ? 87  ASN H N   1 
ATOM   615  C CA  . ASN A 1 84  ? 213.599 175.864 234.649 1.00 54.06 ? 87  ASN H CA  1 
ATOM   616  C C   . ASN A 1 84  ? 214.200 176.961 235.526 1.00 54.06 ? 87  ASN H C   1 
ATOM   617  O O   . ASN A 1 84  ? 213.516 177.913 235.908 1.00 54.06 ? 87  ASN H O   1 
ATOM   618  C CB  . ASN A 1 84  ? 214.559 175.382 233.567 1.00 54.06 ? 87  ASN H CB  1 
ATOM   619  C CG  . ASN A 1 84  ? 214.192 174.012 233.040 1.00 54.06 ? 87  ASN H CG  1 
ATOM   620  O OD1 . ASN A 1 84  ? 213.493 173.248 233.706 1.00 54.06 ? 87  ASN H OD1 1 
ATOM   621  N ND2 . ASN A 1 84  ? 214.662 173.692 231.840 1.00 54.06 ? 87  ASN H ND2 1 
ATOM   622  N N   . SER A 1 85  ? 215.474 176.811 235.885 1.00 53.84 ? 88  SER H N   1 
ATOM   623  C CA  . SER A 1 85  ? 216.177 177.732 236.772 1.00 53.84 ? 88  SER H CA  1 
ATOM   624  C C   . SER A 1 85  ? 215.888 179.186 236.430 1.00 53.84 ? 88  SER H C   1 
ATOM   625  O O   . SER A 1 85  ? 216.163 179.642 235.317 1.00 53.84 ? 88  SER H O   1 
ATOM   626  C CB  . SER A 1 85  ? 217.680 177.468 236.689 1.00 53.84 ? 88  SER H CB  1 
ATOM   627  O OG  . SER A 1 85  ? 218.173 177.754 235.392 1.00 53.84 ? 88  SER H OG  1 
ATOM   628  N N   . LEU A 1 86  ? 215.343 179.919 237.398 1.00 54.83 ? 89  LEU H N   1 
ATOM   629  C CA  . LEU A 1 86  ? 214.892 181.288 237.190 1.00 54.83 ? 89  LEU H CA  1 
ATOM   630  C C   . LEU A 1 86  ? 215.919 182.272 237.732 1.00 54.83 ? 89  LEU H C   1 
ATOM   631  O O   . LEU A 1 86  ? 216.481 182.062 238.811 1.00 54.83 ? 89  LEU H O   1 
ATOM   632  C CB  . LEU A 1 86  ? 213.533 181.510 237.848 1.00 54.83 ? 89  LEU H CB  1 
ATOM   633  C CG  . LEU A 1 86  ? 212.460 180.546 237.345 1.00 54.83 ? 89  LEU H CG  1 
ATOM   634  C CD1 . LEU A 1 86  ? 211.217 180.620 238.197 1.00 54.83 ? 89  LEU H CD1 1 
ATOM   635  C CD2 . LEU A 1 86  ? 212.124 180.832 235.890 1.00 54.83 ? 89  LEU H CD2 1 
ATOM   636  N N   . ARG A 1 87  ? 216.153 183.349 236.980 1.00 57.67 ? 90  ARG H N   1 
ATOM   637  C CA  . ARG A 1 87  ? 217.264 184.260 237.214 1.00 57.67 ? 90  ARG H CA  1 
ATOM   638  C C   . ARG A 1 87  ? 216.865 185.521 237.966 1.00 57.67 ? 90  ARG H C   1 
ATOM   639  O O   . ARG A 1 87  ? 217.660 186.464 238.024 1.00 57.67 ? 90  ARG H O   1 
ATOM   640  C CB  . ARG A 1 87  ? 217.912 184.654 235.886 1.00 57.67 ? 90  ARG H CB  1 
ATOM   641  C CG  . ARG A 1 87  ? 218.539 183.512 235.122 1.00 57.67 ? 90  ARG H CG  1 
ATOM   642  C CD  . ARG A 1 87  ? 218.599 183.838 233.645 1.00 57.67 ? 90  ARG H CD  1 
ATOM   643  N NE  . ARG A 1 87  ? 218.967 185.229 233.415 1.00 57.67 ? 90  ARG H NE  1 
ATOM   644  C CZ  . ARG A 1 87  ? 219.270 185.738 232.229 1.00 57.67 ? 90  ARG H CZ  1 
ATOM   645  N NH1 . ARG A 1 87  ? 219.262 184.995 231.135 1.00 57.67 ? 90  ARG H NH1 1 
ATOM   646  N NH2 . ARG A 1 87  ? 219.591 187.026 232.139 1.00 57.67 ? 90  ARG H NH2 1 
ATOM   647  N N   . ALA A 1 88  ? 215.654 185.571 238.516 1.00 55.27 ? 91  ALA H N   1 
ATOM   648  C CA  . ALA A 1 88  ? 215.115 186.676 239.306 1.00 55.27 ? 91  ALA H CA  1 
ATOM   649  C C   . ALA A 1 88  ? 214.831 187.928 238.486 1.00 55.27 ? 91  ALA H C   1 
ATOM   650  O O   . ALA A 1 88  ? 214.317 188.904 239.040 1.00 55.27 ? 91  ALA H O   1 
ATOM   651  C CB  . ALA A 1 88  ? 216.021 187.061 240.485 1.00 55.27 ? 91  ALA H CB  1 
ATOM   652  N N   . GLU A 1 89  ? 215.145 187.942 237.196 1.00 56.55 ? 92  GLU H N   1 
ATOM   653  C CA  . GLU A 1 89  ? 214.729 189.022 236.314 1.00 56.55 ? 92  GLU H CA  1 
ATOM   654  C C   . GLU A 1 89  ? 213.426 188.712 235.595 1.00 56.55 ? 92  GLU H C   1 
ATOM   655  O O   . GLU A 1 89  ? 212.997 189.503 234.750 1.00 56.55 ? 92  GLU H O   1 
ATOM   656  C CB  . GLU A 1 89  ? 215.823 189.327 235.288 1.00 56.55 ? 92  GLU H CB  1 
ATOM   657  C CG  . GLU A 1 89  ? 216.642 190.568 235.601 1.00 56.55 ? 92  GLU H CG  1 
ATOM   658  C CD  . GLU A 1 89  ? 217.783 190.294 236.562 1.00 56.55 ? 92  GLU H CD  1 
ATOM   659  O OE1 . GLU A 1 89  ? 217.902 189.147 237.040 1.00 56.55 ? 92  GLU H OE1 1 
ATOM   660  O OE2 . GLU A 1 89  ? 218.563 191.229 236.840 1.00 56.55 ? 92  GLU H OE2 1 
ATOM   661  N N   . ASP A 1 90  ? 212.797 187.576 235.902 1.00 53.40 ? 93  ASP H N   1 
ATOM   662  C CA  . ASP A 1 90  ? 211.529 187.180 235.305 1.00 53.40 ? 93  ASP H CA  1 
ATOM   663  C C   . ASP A 1 90  ? 210.382 187.217 236.306 1.00 53.40 ? 93  ASP H C   1 
ATOM   664  O O   . ASP A 1 90  ? 209.359 186.560 236.095 1.00 53.40 ? 93  ASP H O   1 
ATOM   665  C CB  . ASP A 1 90  ? 211.641 185.787 234.689 1.00 53.40 ? 93  ASP H CB  1 
ATOM   666  C CG  . ASP A 1 90  ? 212.438 184.834 235.548 1.00 53.40 ? 93  ASP H CG  1 
ATOM   667  O OD1 . ASP A 1 90  ? 212.562 185.090 236.763 1.00 53.40 ? 93  ASP H OD1 1 
ATOM   668  O OD2 . ASP A 1 90  ? 212.938 183.826 235.008 1.00 53.40 ? 93  ASP H OD2 1 
ATOM   669  N N   . THR A 1 91  ? 210.533 187.964 237.396 1.00 48.97 ? 94  THR H N   1 
ATOM   670  C CA  . THR A 1 91  ? 209.452 188.108 238.358 1.00 48.97 ? 94  THR H CA  1 
ATOM   671  C C   . THR A 1 91  ? 208.384 189.013 237.773 1.00 48.97 ? 94  THR H C   1 
ATOM   672  O O   . THR A 1 91  ? 208.484 190.238 237.875 1.00 48.97 ? 94  THR H O   1 
ATOM   673  C CB  . THR A 1 91  ? 209.966 188.691 239.670 1.00 48.97 ? 94  THR H CB  1 
ATOM   674  O OG1 . THR A 1 91  ? 210.127 190.106 239.524 1.00 48.97 ? 94  THR H OG1 1 
ATOM   675  C CG2 . THR A 1 91  ? 211.306 188.084 240.023 1.00 48.97 ? 94  THR H CG2 1 
ATOM   676  N N   . ALA A 1 92  ? 207.362 188.429 237.159 1.00 45.65 ? 95  ALA H N   1 
ATOM   677  C CA  . ALA A 1 92  ? 206.383 189.231 236.445 1.00 45.65 ? 95  ALA H CA  1 
ATOM   678  C C   . ALA A 1 92  ? 205.078 188.463 236.342 1.00 45.65 ? 95  ALA H C   1 
ATOM   679  O O   . ALA A 1 92  ? 205.028 187.253 236.570 1.00 45.65 ? 95  ALA H O   1 
ATOM   680  C CB  . ALA A 1 92  ? 206.897 189.610 235.057 1.00 45.65 ? 95  ALA H CB  1 
ATOM   681  N N   . VAL A 1 93  ? 204.017 189.188 235.995 1.00 44.01 ? 96  VAL H N   1 
ATOM   682  C CA  . VAL A 1 93  ? 202.732 188.555 235.729 1.00 44.01 ? 96  VAL H CA  1 
ATOM   683  C C   . VAL A 1 93  ? 202.794 187.812 234.398 1.00 44.01 ? 96  VAL H C   1 
ATOM   684  O O   . VAL A 1 93  ? 203.626 188.098 233.534 1.00 44.01 ? 96  VAL H O   1 
ATOM   685  C CB  . VAL A 1 93  ? 201.600 189.592 235.741 1.00 44.01 ? 96  VAL H CB  1 
ATOM   686  C CG1 . VAL A 1 93  ? 201.780 190.549 236.898 1.00 44.01 ? 96  VAL H CG1 1 
ATOM   687  C CG2 . VAL A 1 93  ? 201.588 190.354 234.443 1.00 44.01 ? 96  VAL H CG2 1 
ATOM   688  N N   . TYR A 1 94  ? 201.911 186.828 234.235 1.00 44.68 ? 97  TYR H N   1 
ATOM   689  C CA  . TYR A 1 94  ? 201.946 185.950 233.067 1.00 44.68 ? 97  TYR H CA  1 
ATOM   690  C C   . TYR A 1 94  ? 200.543 185.783 232.500 1.00 44.68 ? 97  TYR H C   1 
ATOM   691  O O   . TYR A 1 94  ? 199.660 185.238 233.170 1.00 44.68 ? 97  TYR H O   1 
ATOM   692  C CB  . TYR A 1 94  ? 202.552 184.593 233.422 1.00 44.68 ? 97  TYR H CB  1 
ATOM   693  C CG  . TYR A 1 94  ? 204.053 184.550 233.271 1.00 44.68 ? 97  TYR H CG  1 
ATOM   694  C CD1 . TYR A 1 94  ? 204.875 185.269 234.119 1.00 44.68 ? 97  TYR H CD1 1 
ATOM   695  C CD2 . TYR A 1 94  ? 204.645 183.811 232.264 1.00 44.68 ? 97  TYR H CD2 1 
ATOM   696  C CE1 . TYR A 1 94  ? 206.240 185.242 233.979 1.00 44.68 ? 97  TYR H CE1 1 
ATOM   697  C CE2 . TYR A 1 94  ? 206.010 183.781 232.114 1.00 44.68 ? 97  TYR H CE2 1 
ATOM   698  C CZ  . TYR A 1 94  ? 206.803 184.495 232.976 1.00 44.68 ? 97  TYR H CZ  1 
ATOM   699  O OH  . TYR A 1 94  ? 208.168 184.465 232.831 1.00 44.68 ? 97  TYR H OH  1 
ATOM   700  N N   . TYR A 1 95  ? 200.346 186.230 231.263 1.00 42.91 ? 98  TYR H N   1 
ATOM   701  C CA  . TYR A 1 95  ? 199.066 186.145 230.581 1.00 42.91 ? 98  TYR H CA  1 
ATOM   702  C C   . TYR A 1 95  ? 199.123 185.097 229.478 1.00 42.91 ? 98  TYR H C   1 
ATOM   703  O O   . TYR A 1 95  ? 200.183 184.832 228.908 1.00 42.91 ? 98  TYR H O   1 
ATOM   704  C CB  . TYR A 1 95  ? 198.672 187.492 229.974 1.00 42.91 ? 98  TYR H CB  1 
ATOM   705  C CG  . TYR A 1 95  ? 198.506 188.613 230.967 1.00 42.91 ? 98  TYR H CG  1 
ATOM   706  C CD1 . TYR A 1 95  ? 197.374 188.702 231.756 1.00 42.91 ? 98  TYR H CD1 1 
ATOM   707  C CD2 . TYR A 1 95  ? 199.467 189.598 231.096 1.00 42.91 ? 98  TYR H CD2 1 
ATOM   708  C CE1 . TYR A 1 95  ? 197.215 189.731 232.658 1.00 42.91 ? 98  TYR H CE1 1 
ATOM   709  C CE2 . TYR A 1 95  ? 199.311 190.631 231.991 1.00 42.91 ? 98  TYR H CE2 1 
ATOM   710  C CZ  . TYR A 1 95  ? 198.190 190.692 232.770 1.00 42.91 ? 98  TYR H CZ  1 
ATOM   711  O OH  . TYR A 1 95  ? 198.037 191.719 233.665 1.00 42.91 ? 98  TYR H OH  1 
ATOM   712  N N   . CYS A 1 96  ? 197.974 184.502 229.180 1.00 46.32 ? 99  CYS H N   1 
ATOM   713  C CA  . CYS A 1 96  ? 197.836 183.539 228.098 1.00 46.32 ? 99  CYS H CA  1 
ATOM   714  C C   . CYS A 1 96  ? 196.951 184.126 227.008 1.00 46.32 ? 99  CYS H C   1 
ATOM   715  O O   . CYS A 1 96  ? 195.968 184.811 227.301 1.00 46.32 ? 99  CYS H O   1 
ATOM   716  C CB  . CYS A 1 96  ? 197.242 182.228 228.611 1.00 46.32 ? 99  CYS H CB  1 
ATOM   717  S SG  . CYS A 1 96  ? 197.684 180.769 227.658 1.00 46.32 ? 99  CYS H SG  1 
ATOM   718  N N   . ALA A 1 97  ? 197.296 183.859 225.751 1.00 41.67 ? 100 ALA H N   1 
ATOM   719  C CA  . ALA A 1 97  ? 196.615 184.491 224.630 1.00 41.67 ? 100 ALA H CA  1 
ATOM   720  C C   . ALA A 1 97  ? 196.301 183.456 223.559 1.00 41.67 ? 100 ALA H C   1 
ATOM   721  O O   . ALA A 1 97  ? 196.804 182.330 223.585 1.00 41.67 ? 100 ALA H O   1 
ATOM   722  C CB  . ALA A 1 97  ? 197.453 185.633 224.055 1.00 41.67 ? 100 ALA H CB  1 
ATOM   723  N N   . ARG A 1 98  ? 195.457 183.850 222.605 1.00 43.30 ? 101 ARG H N   1 
ATOM   724  C CA  . ARG A 1 98  ? 194.966 182.958 221.561 1.00 43.30 ? 101 ARG H CA  1 
ATOM   725  C C   . ARG A 1 98  ? 195.064 183.645 220.206 1.00 43.30 ? 101 ARG H C   1 
ATOM   726  O O   . ARG A 1 98  ? 194.613 184.782 220.051 1.00 43.30 ? 101 ARG H O   1 
ATOM   727  C CB  . ARG A 1 98  ? 193.519 182.544 221.837 1.00 43.30 ? 101 ARG H CB  1 
ATOM   728  C CG  . ARG A 1 98  ? 192.995 181.463 220.926 1.00 43.30 ? 101 ARG H CG  1 
ATOM   729  C CD  . ARG A 1 98  ? 191.479 181.393 220.960 1.00 43.30 ? 101 ARG H CD  1 
ATOM   730  N NE  . ARG A 1 98  ? 190.859 182.477 220.208 1.00 43.30 ? 101 ARG H NE  1 
ATOM   731  C CZ  . ARG A 1 98  ? 189.598 182.477 219.802 1.00 43.30 ? 101 ARG H CZ  1 
ATOM   732  N NH1 . ARG A 1 98  ? 188.789 181.464 220.059 1.00 43.30 ? 101 ARG H NH1 1 
ATOM   733  N NH2 . ARG A 1 98  ? 189.136 183.523 219.125 1.00 43.30 ? 101 ARG H NH2 1 
ATOM   734  N N   . TRP A 1 99  ? 195.642 182.951 219.227 1.00 40.37 ? 102 TRP H N   1 
ATOM   735  C CA  . TRP A 1 99  ? 195.820 183.481 217.879 1.00 40.37 ? 102 TRP H CA  1 
ATOM   736  C C   . TRP A 1 99  ? 195.506 182.374 216.887 1.00 40.37 ? 102 TRP H C   1 
ATOM   737  O O   . TRP A 1 99  ? 196.087 181.289 216.969 1.00 40.37 ? 102 TRP H O   1 
ATOM   738  C CB  . TRP A 1 99  ? 197.246 183.998 217.675 1.00 40.37 ? 102 TRP H CB  1 
ATOM   739  C CG  . TRP A 1 99  ? 197.473 184.725 216.388 1.00 40.37 ? 102 TRP H CG  1 
ATOM   740  C CD1 . TRP A 1 99  ? 196.543 185.031 215.448 1.00 40.37 ? 102 TRP H CD1 1 
ATOM   741  C CD2 . TRP A 1 99  ? 198.716 185.237 215.903 1.00 40.37 ? 102 TRP H CD2 1 
ATOM   742  N NE1 . TRP A 1 99  ? 197.127 185.701 214.405 1.00 40.37 ? 102 TRP H NE1 1 
ATOM   743  C CE2 . TRP A 1 99  ? 198.464 185.838 214.662 1.00 40.37 ? 102 TRP H CE2 1 
ATOM   744  C CE3 . TRP A 1 99  ? 200.019 185.242 216.399 1.00 40.37 ? 102 TRP H CE3 1 
ATOM   745  C CZ2 . TRP A 1 99  ? 199.462 186.443 213.912 1.00 40.37 ? 102 TRP H CZ2 1 
ATOM   746  C CZ3 . TRP A 1 99  ? 201.004 185.836 215.655 1.00 40.37 ? 102 TRP H CZ3 1 
ATOM   747  C CH2 . TRP A 1 99  ? 200.724 186.426 214.424 1.00 40.37 ? 102 TRP H CH2 1 
ATOM   748  N N   . GLY A 1 100 ? 194.607 182.650 215.946 1.00 41.49 ? 103 GLY H N   1 
ATOM   749  C CA  . GLY A 1 100 ? 194.136 181.641 215.023 1.00 41.49 ? 103 GLY H CA  1 
ATOM   750  C C   . GLY A 1 100 ? 195.131 181.335 213.926 1.00 41.49 ? 103 GLY H C   1 
ATOM   751  O O   . GLY A 1 100 ? 196.211 181.917 213.835 1.00 41.49 ? 103 GLY H O   1 
ATOM   752  N N   . TYR A 1 101 ? 194.747 180.395 213.067 1.00 43.61 ? 104 TYR H N   1 
ATOM   753  C CA  . TYR A 1 101 ? 195.634 179.925 212.016 1.00 43.61 ? 104 TYR H CA  1 
ATOM   754  C C   . TYR A 1 101 ? 195.501 180.798 210.770 1.00 43.61 ? 104 TYR H C   1 
ATOM   755  O O   . TYR A 1 101 ? 194.698 181.731 210.712 1.00 43.61 ? 104 TYR H O   1 
ATOM   756  C CB  . TYR A 1 101 ? 195.359 178.456 211.715 1.00 43.61 ? 104 TYR H CB  1 
ATOM   757  C CG  . TYR A 1 101 ? 196.128 177.521 212.615 1.00 43.61 ? 104 TYR H CG  1 
ATOM   758  C CD1 . TYR A 1 101 ? 197.510 177.536 212.637 1.00 43.61 ? 104 TYR H CD1 1 
ATOM   759  C CD2 . TYR A 1 101 ? 195.473 176.634 213.449 1.00 43.61 ? 104 TYR H CD2 1 
ATOM   760  C CE1 . TYR A 1 101 ? 198.218 176.688 213.456 1.00 43.61 ? 104 TYR H CE1 1 
ATOM   761  C CE2 . TYR A 1 101 ? 196.172 175.781 214.272 1.00 43.61 ? 104 TYR H CE2 1 
ATOM   762  C CZ  . TYR A 1 101 ? 197.545 175.812 214.272 1.00 43.61 ? 104 TYR H CZ  1 
ATOM   763  O OH  . TYR A 1 101 ? 198.251 174.967 215.091 1.00 43.61 ? 104 TYR H OH  1 
ATOM   764  N N   . TRP A 1 102 ? 196.306 180.476 209.747 1.00 41.89 ? 105 TRP H N   1 
ATOM   765  C CA  . TRP A 1 102 ? 196.558 181.446 208.680 1.00 41.89 ? 105 TRP H CA  1 
ATOM   766  C C   . TRP A 1 102 ? 195.344 181.706 207.800 1.00 41.89 ? 105 TRP H C   1 
ATOM   767  O O   . TRP A 1 102 ? 194.838 182.843 207.797 1.00 41.89 ? 105 TRP H O   1 
ATOM   768  C CB  . TRP A 1 102 ? 197.769 181.013 207.854 1.00 41.89 ? 105 TRP H CB  1 
ATOM   769  C CG  . TRP A 1 102 ? 197.736 181.520 206.453 1.00 41.89 ? 105 TRP H CG  1 
ATOM   770  C CD1 . TRP A 1 102 ? 197.720 180.776 205.319 1.00 41.89 ? 105 TRP H CD1 1 
ATOM   771  C CD2 . TRP A 1 102 ? 197.710 182.888 206.036 1.00 41.89 ? 105 TRP H CD2 1 
ATOM   772  N NE1 . TRP A 1 102 ? 197.689 181.592 204.217 1.00 41.89 ? 105 TRP H NE1 1 
ATOM   773  C CE2 . TRP A 1 102 ? 197.684 182.895 204.635 1.00 41.89 ? 105 TRP H CE2 1 
ATOM   774  C CE3 . TRP A 1 102 ? 197.710 184.106 206.713 1.00 41.89 ? 105 TRP H CE3 1 
ATOM   775  C CZ2 . TRP A 1 102 ? 197.657 184.069 203.900 1.00 41.89 ? 105 TRP H CZ2 1 
ATOM   776  C CZ3 . TRP A 1 102 ? 197.683 185.268 205.982 1.00 41.89 ? 105 TRP H CZ3 1 
ATOM   777  C CH2 . TRP A 1 102 ? 197.656 185.243 204.592 1.00 41.89 ? 105 TRP H CH2 1 
ATOM   778  N N   . PRO A 1 103 ? 194.828 180.735 207.030 1.00 41.79 ? 106 PRO H N   1 
ATOM   779  C CA  . PRO A 1 103 ? 193.911 181.095 205.941 1.00 41.79 ? 106 PRO H CA  1 
ATOM   780  C C   . PRO A 1 103 ? 192.625 181.738 206.423 1.00 41.79 ? 106 PRO H C   1 
ATOM   781  O O   . PRO A 1 103 ? 191.796 181.094 207.072 1.00 41.79 ? 106 PRO H O   1 
ATOM   782  C CB  . PRO A 1 103 ? 193.640 179.752 205.256 1.00 41.79 ? 106 PRO H CB  1 
ATOM   783  C CG  . PRO A 1 103 ? 193.827 178.754 206.321 1.00 41.79 ? 106 PRO H CG  1 
ATOM   784  C CD  . PRO A 1 103 ? 194.931 179.274 207.190 1.00 41.79 ? 106 PRO H CD  1 
ATOM   785  N N   . GLY A 1 104 ? 192.460 183.014 206.113 1.00 42.98 ? 107 GLY H N   1 
ATOM   786  C CA  . GLY A 1 104 ? 191.245 183.732 206.412 1.00 42.98 ? 107 GLY H CA  1 
ATOM   787  C C   . GLY A 1 104 ? 191.431 184.800 207.471 1.00 42.98 ? 107 GLY H C   1 
ATOM   788  O O   . GLY A 1 104 ? 192.528 185.308 207.712 1.00 42.98 ? 107 GLY H O   1 
ATOM   789  N N   . GLU A 1 105 ? 190.320 185.142 208.110 1.00 43.21 ? 108 GLU H N   1 
ATOM   790  C CA  . GLU A 1 105 ? 190.220 186.178 209.129 1.00 43.21 ? 108 GLU H CA  1 
ATOM   791  C C   . GLU A 1 105 ? 190.795 185.799 210.493 1.00 43.21 ? 108 GLU H C   1 
ATOM   792  O O   . GLU A 1 105 ? 191.330 186.683 211.173 1.00 43.21 ? 108 GLU H O   1 
ATOM   793  C CB  . GLU A 1 105 ? 188.759 186.595 209.298 1.00 43.21 ? 108 GLU H CB  1 
ATOM   794  C CG  . GLU A 1 105 ? 188.199 187.368 208.118 1.00 43.21 ? 108 GLU H CG  1 
ATOM   795  C CD  . GLU A 1 105 ? 186.783 187.852 208.358 1.00 43.21 ? 108 GLU H CD  1 
ATOM   796  O OE1 . GLU A 1 105 ? 186.353 187.879 209.530 1.00 43.21 ? 108 GLU H OE1 1 
ATOM   797  O OE2 . GLU A 1 105 ? 186.099 188.204 207.374 1.00 43.21 ? 108 GLU H OE2 1 
ATOM   798  N N   . PRO A 1 106 ? 190.697 184.542 210.955 1.00 39.23 ? 109 PRO H N   1 
ATOM   799  C CA  . PRO A 1 106 ? 191.192 184.236 212.308 1.00 39.23 ? 109 PRO H CA  1 
ATOM   800  C C   . PRO A 1 106 ? 192.636 184.631 212.547 1.00 39.23 ? 109 PRO H C   1 
ATOM   801  O O   . PRO A 1 106 ? 193.005 184.932 213.687 1.00 39.23 ? 109 PRO H O   1 
ATOM   802  C CB  . PRO A 1 106 ? 191.002 182.721 212.403 1.00 39.23 ? 109 PRO H CB  1 
ATOM   803  C CG  . PRO A 1 106 ? 189.842 182.459 211.574 1.00 39.23 ? 109 PRO H CG  1 
ATOM   804  C CD  . PRO A 1 106 ? 189.938 183.400 210.414 1.00 39.23 ? 109 PRO H CD  1 
ATOM   805  N N   . TRP A 1 107 ? 193.468 184.642 211.507 1.00 39.86 ? 110 TRP H N   1 
ATOM   806  C CA  . TRP A 1 107 ? 194.844 185.092 211.670 1.00 39.86 ? 110 TRP H CA  1 
ATOM   807  C C   . TRP A 1 107 ? 194.918 186.578 211.990 1.00 39.86 ? 110 TRP H C   1 
ATOM   808  O O   . TRP A 1 107 ? 195.773 186.998 212.777 1.00 39.86 ? 110 TRP H O   1 
ATOM   809  C CB  . TRP A 1 107 ? 195.643 184.777 210.411 1.00 39.86 ? 110 TRP H CB  1 
ATOM   810  C CG  . TRP A 1 107 ? 197.102 184.951 210.581 1.00 39.86 ? 110 TRP H CG  1 
ATOM   811  C CD1 . TRP A 1 107 ? 197.949 184.130 211.257 1.00 39.86 ? 110 TRP H CD1 1 
ATOM   812  C CD2 . TRP A 1 107 ? 197.899 186.012 210.061 1.00 39.86 ? 110 TRP H CD2 1 
ATOM   813  N NE1 . TRP A 1 107 ? 199.227 184.617 211.193 1.00 39.86 ? 110 TRP H NE1 1 
ATOM   814  C CE2 . TRP A 1 107 ? 199.221 185.774 210.461 1.00 39.86 ? 110 TRP H CE2 1 
ATOM   815  C CE3 . TRP A 1 107 ? 197.621 187.144 209.294 1.00 39.86 ? 110 TRP H CE3 1 
ATOM   816  C CZ2 . TRP A 1 107 ? 200.262 186.624 210.125 1.00 39.86 ? 110 TRP H CZ2 1 
ATOM   817  C CZ3 . TRP A 1 107 ? 198.657 187.985 208.961 1.00 39.86 ? 110 TRP H CZ3 1 
ATOM   818  C CH2 . TRP A 1 107 ? 199.961 187.722 209.378 1.00 39.86 ? 110 TRP H CH2 1 
ATOM   819  N N   . TRP A 1 108 ? 194.034 187.385 211.403 1.00 40.45 ? 111 TRP H N   1 
ATOM   820  C CA  . TRP A 1 108 ? 194.104 188.831 211.570 1.00 40.45 ? 111 TRP H CA  1 
ATOM   821  C C   . TRP A 1 108 ? 193.632 189.286 212.944 1.00 40.45 ? 111 TRP H C   1 
ATOM   822  O O   . TRP A 1 108 ? 194.069 190.334 213.426 1.00 40.45 ? 111 TRP H O   1 
ATOM   823  C CB  . TRP A 1 108 ? 193.289 189.514 210.476 1.00 40.45 ? 111 TRP H CB  1 
ATOM   824  C CG  . TRP A 1 108 ? 193.877 189.309 209.133 1.00 40.45 ? 111 TRP H CG  1 
ATOM   825  C CD1 . TRP A 1 108 ? 193.426 188.474 208.162 1.00 40.45 ? 111 TRP H CD1 1 
ATOM   826  C CD2 . TRP A 1 108 ? 195.048 189.936 208.613 1.00 40.45 ? 111 TRP H CD2 1 
ATOM   827  N NE1 . TRP A 1 108 ? 194.240 188.547 207.062 1.00 40.45 ? 111 TRP H NE1 1 
ATOM   828  C CE2 . TRP A 1 108 ? 195.245 189.439 207.317 1.00 40.45 ? 111 TRP H CE2 1 
ATOM   829  C CE3 . TRP A 1 108 ? 195.948 190.875 209.118 1.00 40.45 ? 111 TRP H CE3 1 
ATOM   830  C CZ2 . TRP A 1 108 ? 196.301 189.851 206.519 1.00 40.45 ? 111 TRP H CZ2 1 
ATOM   831  C CZ3 . TRP A 1 108 ? 196.996 191.280 208.323 1.00 40.45 ? 111 TRP H CZ3 1 
ATOM   832  C CH2 . TRP A 1 108 ? 197.164 190.771 207.040 1.00 40.45 ? 111 TRP H CH2 1 
ATOM   833  N N   . LYS A 1 109 ? 192.755 188.521 213.588 1.00 41.35 ? 112 LYS H N   1 
ATOM   834  C CA  . LYS A 1 109 ? 192.299 188.836 214.939 1.00 41.35 ? 112 LYS H CA  1 
ATOM   835  C C   . LYS A 1 109 ? 193.304 188.271 215.943 1.00 41.35 ? 112 LYS H C   1 
ATOM   836  O O   . LYS A 1 109 ? 193.057 187.297 216.656 1.00 41.35 ? 112 LYS H O   1 
ATOM   837  C CB  . LYS A 1 109 ? 190.898 188.288 215.160 1.00 41.35 ? 112 LYS H CB  1 
ATOM   838  C CG  . LYS A 1 109 ? 189.868 188.919 214.248 1.00 41.35 ? 112 LYS H CG  1 
ATOM   839  C CD  . LYS A 1 109 ? 188.735 187.971 213.928 1.00 41.35 ? 112 LYS H CD  1 
ATOM   840  C CE  . LYS A 1 109 ? 187.639 188.044 214.965 1.00 41.35 ? 112 LYS H CE  1 
ATOM   841  N NZ  . LYS A 1 109 ? 186.401 187.367 214.494 1.00 41.35 ? 112 LYS H NZ  1 
ATOM   842  N N   . ALA A 1 110 ? 194.469 188.912 215.987 1.00 40.61 ? 113 ALA H N   1 
ATOM   843  C CA  . ALA A 1 110 ? 195.566 188.441 216.818 1.00 40.61 ? 113 ALA H CA  1 
ATOM   844  C C   . ALA A 1 110 ? 195.311 188.759 218.283 1.00 40.61 ? 113 ALA H C   1 
ATOM   845  O O   . ALA A 1 110 ? 195.003 189.903 218.633 1.00 40.61 ? 113 ALA H O   1 
ATOM   846  C CB  . ALA A 1 110 ? 196.881 189.074 216.369 1.00 40.61 ? 113 ALA H CB  1 
ATOM   847  N N   . PHE A 1 111 ? 195.458 187.746 219.137 1.00 41.55 ? 114 PHE H N   1 
ATOM   848  C CA  . PHE A 1 111 ? 195.308 187.886 220.586 1.00 41.55 ? 114 PHE H CA  1 
ATOM   849  C C   . PHE A 1 111 ? 193.973 188.535 220.944 1.00 41.55 ? 114 PHE H C   1 
ATOM   850  O O   . PHE A 1 111 ? 193.910 189.532 221.664 1.00 41.55 ? 114 PHE H O   1 
ATOM   851  C CB  . PHE A 1 111 ? 196.476 188.669 221.184 1.00 41.55 ? 114 PHE H CB  1 
ATOM   852  C CG  . PHE A 1 111 ? 197.796 187.962 221.094 1.00 41.55 ? 114 PHE H CG  1 
ATOM   853  C CD1 . PHE A 1 111 ? 197.857 186.610 220.834 1.00 41.55 ? 114 PHE H CD1 1 
ATOM   854  C CD2 . PHE A 1 111 ? 198.977 188.654 221.265 1.00 41.55 ? 114 PHE H CD2 1 
ATOM   855  C CE1 . PHE A 1 111 ? 199.065 185.964 220.756 1.00 41.55 ? 114 PHE H CE1 1 
ATOM   856  C CE2 . PHE A 1 111 ? 200.188 188.010 221.184 1.00 41.55 ? 114 PHE H CE2 1 
ATOM   857  C CZ  . PHE A 1 111 ? 200.231 186.665 220.931 1.00 41.55 ? 114 PHE H CZ  1 
ATOM   858  N N   . ASP A 1 112 ? 192.893 187.959 220.417 1.00 43.49 ? 115 ASP H N   1 
ATOM   859  C CA  . ASP A 1 112 ? 191.568 188.513 220.657 1.00 43.49 ? 115 ASP H CA  1 
ATOM   860  C C   . ASP A 1 112 ? 191.061 188.190 222.054 1.00 43.49 ? 115 ASP H C   1 
ATOM   861  O O   . ASP A 1 112 ? 190.390 189.019 222.677 1.00 43.49 ? 115 ASP H O   1 
ATOM   862  C CB  . ASP A 1 112 ? 190.588 188.006 219.605 1.00 43.49 ? 115 ASP H CB  1 
ATOM   863  C CG  . ASP A 1 112 ? 190.771 186.541 219.299 1.00 43.49 ? 115 ASP H CG  1 
ATOM   864  O OD1 . ASP A 1 112 ? 190.954 185.752 220.249 1.00 43.49 ? 115 ASP H OD1 1 
ATOM   865  O OD2 . ASP A 1 112 ? 190.731 186.174 218.108 1.00 43.49 ? 115 ASP H OD2 1 
ATOM   866  N N   . TYR A 1 113 ? 191.359 187.001 222.567 1.00 45.02 ? 116 TYR H N   1 
ATOM   867  C CA  . TYR A 1 113 ? 190.976 186.627 223.921 1.00 45.02 ? 116 TYR H CA  1 
ATOM   868  C C   . TYR A 1 113 ? 192.232 186.343 224.725 1.00 45.02 ? 116 TYR H C   1 
ATOM   869  O O   . TYR A 1 113 ? 193.014 185.456 224.368 1.00 45.02 ? 116 TYR H O   1 
ATOM   870  C CB  . TYR A 1 113 ? 190.041 185.419 223.917 1.00 45.02 ? 116 TYR H CB  1 
ATOM   871  C CG  . TYR A 1 113 ? 188.654 185.766 223.445 1.00 45.02 ? 116 TYR H CG  1 
ATOM   872  C CD1 . TYR A 1 113 ? 187.853 186.633 224.171 1.00 45.02 ? 116 TYR H CD1 1 
ATOM   873  C CD2 . TYR A 1 113 ? 188.150 185.241 222.268 1.00 45.02 ? 116 TYR H CD2 1 
ATOM   874  C CE1 . TYR A 1 113 ? 186.589 186.962 223.740 1.00 45.02 ? 116 TYR H CE1 1 
ATOM   875  C CE2 . TYR A 1 113 ? 186.888 185.565 221.830 1.00 45.02 ? 116 TYR H CE2 1 
ATOM   876  C CZ  . TYR A 1 113 ? 186.112 186.428 222.567 1.00 45.02 ? 116 TYR H CZ  1 
ATOM   877  O OH  . TYR A 1 113 ? 184.847 186.751 222.136 1.00 45.02 ? 116 TYR H OH  1 
ATOM   878  N N   . TRP A 1 114 ? 192.423 187.093 225.802 1.00 41.50 ? 117 TRP H N   1 
ATOM   879  C CA  . TRP A 1 114 ? 193.536 186.903 226.713 1.00 41.50 ? 117 TRP H CA  1 
ATOM   880  C C   . TRP A 1 114 ? 193.039 186.217 227.978 1.00 41.50 ? 117 TRP H C   1 
ATOM   881  O O   . TRP A 1 114 ? 191.868 185.855 228.104 1.00 41.50 ? 117 TRP H O   1 
ATOM   882  C CB  . TRP A 1 114 ? 194.194 188.239 227.053 1.00 41.50 ? 117 TRP H CB  1 
ATOM   883  C CG  . TRP A 1 114 ? 194.897 188.912 225.921 1.00 41.50 ? 117 TRP H CG  1 
ATOM   884  C CD1 . TRP A 1 114 ? 194.381 189.217 224.703 1.00 41.50 ? 117 TRP H CD1 1 
ATOM   885  C CD2 . TRP A 1 114 ? 196.245 189.388 225.916 1.00 41.50 ? 117 TRP H CD2 1 
ATOM   886  N NE1 . TRP A 1 114 ? 195.324 189.844 223.933 1.00 41.50 ? 117 TRP H NE1 1 
ATOM   887  C CE2 . TRP A 1 114 ? 196.481 189.958 224.657 1.00 41.50 ? 117 TRP H CE2 1 
ATOM   888  C CE3 . TRP A 1 114 ? 197.278 189.378 226.854 1.00 41.50 ? 117 TRP H CE3 1 
ATOM   889  C CZ2 . TRP A 1 114 ? 197.703 190.518 224.311 1.00 41.50 ? 117 TRP H CZ2 1 
ATOM   890  C CZ3 . TRP A 1 114 ? 198.487 189.928 226.510 1.00 41.50 ? 117 TRP H CZ3 1 
ATOM   891  C CH2 . TRP A 1 114 ? 198.692 190.493 225.251 1.00 41.50 ? 117 TRP H CH2 1 
ATOM   892  N N   . GLY A 1 115 ? 193.948 186.041 228.933 1.00 44.99 ? 118 GLY H N   1 
ATOM   893  C CA  . GLY A 1 115 ? 193.607 185.525 230.238 1.00 44.99 ? 118 GLY H CA  1 
ATOM   894  C C   . GLY A 1 115 ? 193.536 186.624 231.283 1.00 44.99 ? 118 GLY H C   1 
ATOM   895  O O   . GLY A 1 115 ? 193.473 187.815 230.979 1.00 44.99 ? 118 GLY H O   1 
ATOM   896  N N   . GLN A 1 116 ? 193.546 186.202 232.544 1.00 49.33 ? 119 GLN H N   1 
ATOM   897  C CA  . GLN A 1 116 ? 193.537 187.138 233.659 1.00 49.33 ? 119 GLN H CA  1 
ATOM   898  C C   . GLN A 1 116 ? 194.916 187.378 234.251 1.00 49.33 ? 119 GLN H C   1 
ATOM   899  O O   . GLN A 1 116 ? 195.142 188.437 234.845 1.00 49.33 ? 119 GLN H O   1 
ATOM   900  C CB  . GLN A 1 116 ? 192.596 186.641 234.762 1.00 49.33 ? 119 GLN H CB  1 
ATOM   901  C CG  . GLN A 1 116 ? 192.226 187.702 235.783 1.00 49.33 ? 119 GLN H CG  1 
ATOM   902  C CD  . GLN A 1 116 ? 191.717 188.977 235.141 1.00 49.33 ? 119 GLN H CD  1 
ATOM   903  O OE1 . GLN A 1 116 ? 192.453 189.954 235.006 1.00 49.33 ? 119 GLN H OE1 1 
ATOM   904  N NE2 . GLN A 1 116 ? 190.452 188.974 234.740 1.00 49.33 ? 119 GLN H NE2 1 
ATOM   905  N N   . GLY A 1 117 ? 195.831 186.437 234.109 1.00 48.38 ? 120 GLY H N   1 
ATOM   906  C CA  . GLY A 1 117 ? 197.187 186.641 234.572 1.00 48.38 ? 120 GLY H CA  1 
ATOM   907  C C   . GLY A 1 117 ? 197.459 185.969 235.903 1.00 48.38 ? 120 GLY H C   1 
ATOM   908  O O   . GLY A 1 117 ? 196.579 185.837 236.761 1.00 48.38 ? 120 GLY H O   1 
ATOM   909  N N   . THR A 1 118 ? 198.704 185.536 236.080 1.00 48.65 ? 121 THR H N   1 
ATOM   910  C CA  . THR A 1 118 ? 199.168 184.936 237.319 1.00 48.65 ? 121 THR H CA  1 
ATOM   911  C C   . THR A 1 118 ? 200.507 185.554 237.694 1.00 48.65 ? 121 THR H C   1 
ATOM   912  O O   . THR A 1 118 ? 201.236 186.053 236.835 1.00 48.65 ? 121 THR H O   1 
ATOM   913  C CB  . THR A 1 118 ? 199.286 183.407 237.193 1.00 48.65 ? 121 THR H CB  1 
ATOM   914  O OG1 . THR A 1 118 ? 199.140 182.803 238.483 1.00 48.65 ? 121 THR H OG1 1 
ATOM   915  C CG2 . THR A 1 118 ? 200.625 183.008 236.592 1.00 48.65 ? 121 THR H CG2 1 
ATOM   916  N N   . LEU A 1 119 ? 200.816 185.539 238.988 1.00 49.93 ? 122 LEU H N   1 
ATOM   917  C CA  . LEU A 1 119 ? 202.031 186.148 239.519 1.00 49.93 ? 122 LEU H CA  1 
ATOM   918  C C   . LEU A 1 119 ? 203.052 185.074 239.862 1.00 49.93 ? 122 LEU H C   1 
ATOM   919  O O   . LEU A 1 119 ? 202.769 184.179 240.664 1.00 49.93 ? 122 LEU H O   1 
ATOM   920  C CB  . LEU A 1 119 ? 201.730 186.978 240.765 1.00 49.93 ? 122 LEU H CB  1 
ATOM   921  C CG  . LEU A 1 119 ? 201.583 188.489 240.651 1.00 49.93 ? 122 LEU H CG  1 
ATOM   922  C CD1 . LEU A 1 119 ? 201.361 189.083 242.025 1.00 49.93 ? 122 LEU H CD1 1 
ATOM   923  C CD2 . LEU A 1 119 ? 202.841 189.065 240.044 1.00 49.93 ? 122 LEU H CD2 1 
ATOM   924  N N   . VAL A 1 120 ? 204.242 185.179 239.279 1.00 47.77 ? 123 VAL H N   1 
ATOM   925  C CA  . VAL A 1 120 ? 205.384 184.365 239.673 1.00 47.77 ? 123 VAL H CA  1 
ATOM   926  C C   . VAL A 1 120 ? 206.493 185.302 240.121 1.00 47.77 ? 123 VAL H C   1 
ATOM   927  O O   . VAL A 1 120 ? 206.865 186.228 239.391 1.00 47.77 ? 123 VAL H O   1 
ATOM   928  C CB  . VAL A 1 120 ? 205.860 183.444 238.537 1.00 47.77 ? 123 VAL H CB  1 
ATOM   929  C CG1 . VAL A 1 120 ? 206.011 184.215 237.255 1.00 47.77 ? 123 VAL H CG1 1 
ATOM   930  C CG2 . VAL A 1 120 ? 207.171 182.778 238.916 1.00 47.77 ? 123 VAL H CG2 1 
ATOM   931  N N   . THR A 1 121 ? 207.008 185.073 241.324 1.00 51.60 ? 124 THR H N   1 
ATOM   932  C CA  . THR A 1 121 ? 207.999 185.949 241.925 1.00 51.60 ? 124 THR H CA  1 
ATOM   933  C C   . THR A 1 121 ? 209.227 185.143 242.317 1.00 51.60 ? 124 THR H C   1 
ATOM   934  O O   . THR A 1 121 ? 209.111 184.034 242.845 1.00 51.60 ? 124 THR H O   1 
ATOM   935  C CB  . THR A 1 121 ? 207.427 186.666 243.154 1.00 51.60 ? 124 THR H CB  1 
ATOM   936  O OG1 . THR A 1 121 ? 206.114 187.152 242.854 1.00 51.60 ? 124 THR H OG1 1 
ATOM   937  C CG2 . THR A 1 121 ? 208.306 187.840 243.546 1.00 51.60 ? 124 THR H CG2 1 
ATOM   938  N N   . VAL A 1 122 ? 210.401 185.708 242.056 1.00 49.88 ? 125 VAL H N   1 
ATOM   939  C CA  . VAL A 1 122 ? 211.677 185.116 242.428 1.00 49.88 ? 125 VAL H CA  1 
ATOM   940  C C   . VAL A 1 122 ? 212.356 186.044 243.419 1.00 49.88 ? 125 VAL H C   1 
ATOM   941  O O   . VAL A 1 122 ? 212.432 187.256 243.187 1.00 49.88 ? 125 VAL H O   1 
ATOM   942  C CB  . VAL A 1 122 ? 212.573 184.885 241.201 1.00 49.88 ? 125 VAL H CB  1 
ATOM   943  C CG1 . VAL A 1 122 ? 213.792 184.069 241.586 1.00 49.88 ? 125 VAL H CG1 1 
ATOM   944  C CG2 . VAL A 1 122 ? 211.788 184.203 240.096 1.00 49.88 ? 125 VAL H CG2 1 
ATOM   945  N N   . SER A 1 123 ? 212.847 185.485 244.518 1.00 48.61 ? 126 SER H N   1 
ATOM   946  C CA  . SER A 1 123 ? 213.472 186.289 245.560 1.00 48.61 ? 126 SER H CA  1 
ATOM   947  C C   . SER A 1 123 ? 214.373 185.386 246.394 1.00 48.61 ? 126 SER H C   1 
ATOM   948  O O   . SER A 1 123 ? 214.634 184.235 246.032 1.00 48.61 ? 126 SER H O   1 
ATOM   949  C CB  . SER A 1 123 ? 212.412 186.988 246.414 1.00 48.61 ? 126 SER H CB  1 
ATOM   950  O OG  . SER A 1 123 ? 212.981 187.523 247.594 1.00 48.61 ? 126 SER H OG  1 
ATOM   951  N N   . SER A 1 124 ? 214.861 185.919 247.515 1.00 48.23 ? 127 SER H N   1 
ATOM   952  C CA  . SER A 1 124 ? 215.655 185.149 248.457 1.00 48.23 ? 127 SER H CA  1 
ATOM   953  C C   . SER A 1 124 ? 215.221 185.344 249.900 1.00 48.23 ? 127 SER H C   1 
ATOM   954  O O   . SER A 1 124 ? 215.775 184.686 250.787 1.00 48.23 ? 127 SER H O   1 
ATOM   955  C CB  . SER A 1 124 ? 217.143 185.501 248.328 1.00 48.23 ? 127 SER H CB  1 
ATOM   956  O OG  . SER A 1 124 ? 217.617 185.230 247.021 1.00 48.23 ? 127 SER H OG  1 
ATOM   957  N N   . ALA A 1 125 ? 214.262 186.222 250.164 1.00 44.89 ? 128 ALA H N   1 
ATOM   958  C CA  . ALA A 1 125 ? 213.781 186.441 251.520 1.00 44.89 ? 128 ALA H CA  1 
ATOM   959  C C   . ALA A 1 125 ? 212.990 185.241 252.018 1.00 44.89 ? 128 ALA H C   1 
ATOM   960  O O   . ALA A 1 125 ? 211.797 185.129 251.755 1.00 44.89 ? 128 ALA H O   1 
ATOM   961  C CB  . ALA A 1 125 ? 212.930 187.696 251.583 1.00 44.89 ? 128 ALA H CB  1 
ATOM   962  N N   . ASP B 2 1   ? 215.556 191.436 216.242 1.00 54.31 ? 2   ASP L N   1 
ATOM   963  C CA  . ASP B 2 1   ? 214.221 191.315 215.672 1.00 54.31 ? 2   ASP L CA  1 
ATOM   964  C C   . ASP B 2 1   ? 213.666 192.685 215.325 1.00 54.31 ? 2   ASP L C   1 
ATOM   965  O O   . ASP B 2 1   ? 214.315 193.701 215.568 1.00 54.31 ? 2   ASP L O   1 
ATOM   966  C CB  . ASP B 2 1   ? 213.285 190.593 216.642 1.00 54.31 ? 2   ASP L CB  1 
ATOM   967  C CG  . ASP B 2 1   ? 212.360 189.617 215.942 1.00 54.31 ? 2   ASP L CG  1 
ATOM   968  O OD1 . ASP B 2 1   ? 212.389 189.558 214.694 1.00 54.31 ? 2   ASP L OD1 1 
ATOM   969  O OD2 . ASP B 2 1   ? 211.603 188.908 216.638 1.00 54.31 ? 2   ASP L OD2 1 
ATOM   970  N N   . ILE B 2 2   ? 212.463 192.714 214.755 1.00 50.85 ? 3   ILE L N   1 
ATOM   971  C CA  . ILE B 2 2   ? 211.861 193.979 214.350 1.00 50.85 ? 3   ILE L CA  1 
ATOM   972  C C   . ILE B 2 2   ? 211.493 194.771 215.597 1.00 50.85 ? 3   ILE L C   1 
ATOM   973  O O   . ILE B 2 2   ? 210.776 194.278 216.474 1.00 50.85 ? 3   ILE L O   1 
ATOM   974  C CB  . ILE B 2 2   ? 210.634 193.748 213.463 1.00 50.85 ? 3   ILE L CB  1 
ATOM   975  C CG1 . ILE B 2 2   ? 210.874 192.604 212.480 1.00 50.85 ? 3   ILE L CG1 1 
ATOM   976  C CG2 . ILE B 2 2   ? 210.258 195.028 212.739 1.00 50.85 ? 3   ILE L CG2 1 
ATOM   977  C CD1 . ILE B 2 2   ? 210.127 191.337 212.837 1.00 50.85 ? 3   ILE L CD1 1 
ATOM   978  N N   . GLN B 2 3   ? 211.975 196.004 215.677 1.00 53.24 ? 4   GLN L N   1 
ATOM   979  C CA  . GLN B 2 3   ? 211.749 196.858 216.833 1.00 53.24 ? 4   GLN L CA  1 
ATOM   980  C C   . GLN B 2 3   ? 210.681 197.885 216.498 1.00 53.24 ? 4   GLN L C   1 
ATOM   981  O O   . GLN B 2 3   ? 210.677 198.446 215.397 1.00 53.24 ? 4   GLN L O   1 
ATOM   982  C CB  . GLN B 2 3   ? 213.041 197.553 217.260 1.00 53.24 ? 4   GLN L CB  1 
ATOM   983  C CG  . GLN B 2 3   ? 212.906 198.381 218.523 1.00 53.24 ? 4   GLN L CG  1 
ATOM   984  C CD  . GLN B 2 3   ? 214.242 198.862 219.044 1.00 53.24 ? 4   GLN L CD  1 
ATOM   985  O OE1 . GLN B 2 3   ? 215.292 198.512 218.507 1.00 53.24 ? 4   GLN L OE1 1 
ATOM   986  N NE2 . GLN B 2 3   ? 214.212 199.667 220.099 1.00 53.24 ? 4   GLN L NE2 1 
ATOM   987  N N   . MET B 2 4   ? 209.775 198.124 217.441 1.00 50.05 ? 5   MET L N   1 
ATOM   988  C CA  . MET B 2 4   ? 208.658 199.035 217.237 1.00 50.05 ? 5   MET L CA  1 
ATOM   989  C C   . MET B 2 4   ? 208.652 200.053 218.365 1.00 50.05 ? 5   MET L C   1 
ATOM   990  O O   . MET B 2 4   ? 208.670 199.677 219.541 1.00 50.05 ? 5   MET L O   1 
ATOM   991  C CB  . MET B 2 4   ? 207.339 198.262 217.179 1.00 50.05 ? 5   MET L CB  1 
ATOM   992  C CG  . MET B 2 4   ? 206.310 198.895 216.281 1.00 50.05 ? 5   MET L CG  1 
ATOM   993  S SD  . MET B 2 4   ? 205.117 197.704 215.660 1.00 50.05 ? 5   MET L SD  1 
ATOM   994  C CE  . MET B 2 4   ? 204.239 198.728 214.487 1.00 50.05 ? 5   MET L CE  1 
ATOM   995  N N   . THR B 2 5   ? 208.627 201.336 218.008 1.00 50.24 ? 6   THR L N   1 
ATOM   996  C CA  . THR B 2 5   ? 208.741 202.429 218.963 1.00 50.24 ? 6   THR L CA  1 
ATOM   997  C C   . THR B 2 5   ? 207.479 203.279 218.948 1.00 50.24 ? 6   THR L C   1 
ATOM   998  O O   . THR B 2 5   ? 206.852 203.458 217.900 1.00 50.24 ? 6   THR L O   1 
ATOM   999  C CB  . THR B 2 5   ? 209.946 203.318 218.651 1.00 50.24 ? 6   THR L CB  1 
ATOM   1000 O OG1 . THR B 2 5   ? 209.553 204.346 217.736 1.00 50.24 ? 6   THR L OG1 1 
ATOM   1001 C CG2 . THR B 2 5   ? 211.067 202.502 218.031 1.00 50.24 ? 6   THR L CG2 1 
ATOM   1002 N N   . GLN B 2 6   ? 207.120 203.809 220.113 1.00 50.08 ? 7   GLN L N   1 
ATOM   1003 C CA  . GLN B 2 6   ? 205.993 204.721 220.263 1.00 50.08 ? 7   GLN L CA  1 
ATOM   1004 C C   . GLN B 2 6   ? 206.525 206.089 220.663 1.00 50.08 ? 7   GLN L C   1 
ATOM   1005 O O   . GLN B 2 6   ? 207.250 206.209 221.656 1.00 50.08 ? 7   GLN L O   1 
ATOM   1006 C CB  . GLN B 2 6   ? 205.004 204.208 221.305 1.00 50.08 ? 7   GLN L CB  1 
ATOM   1007 C CG  . GLN B 2 6   ? 204.048 203.163 220.783 1.00 50.08 ? 7   GLN L CG  1 
ATOM   1008 C CD  . GLN B 2 6   ? 203.167 202.602 221.867 1.00 50.08 ? 7   GLN L CD  1 
ATOM   1009 O OE1 . GLN B 2 6   ? 202.874 201.410 221.891 1.00 50.08 ? 7   GLN L OE1 1 
ATOM   1010 N NE2 . GLN B 2 6   ? 202.744 203.459 222.783 1.00 50.08 ? 7   GLN L NE2 1 
ATOM   1011 N N   . SER B 2 7   ? 206.156 207.120 219.895 1.00 54.21 ? 8   SER L N   1 
ATOM   1012 C CA  . SER B 2 7   ? 206.735 208.442 220.132 1.00 54.21 ? 8   SER L CA  1 
ATOM   1013 C C   . SER B 2 7   ? 206.266 209.060 221.443 1.00 54.21 ? 8   SER L C   1 
ATOM   1014 O O   . SER B 2 7   ? 207.122 209.393 222.282 1.00 54.21 ? 8   SER L O   1 
ATOM   1015 C CB  . SER B 2 7   ? 206.458 209.355 218.933 1.00 54.21 ? 8   SER L CB  1 
ATOM   1016 O OG  . SER B 2 7   ? 206.989 208.807 217.739 1.00 54.21 ? 8   SER L OG  1 
ATOM   1017 N N   . PRO B 2 8   ? 204.958 209.248 221.701 1.00 49.49 ? 9   PRO L N   1 
ATOM   1018 C CA  . PRO B 2 8   ? 204.547 209.939 222.930 1.00 49.49 ? 9   PRO L CA  1 
ATOM   1019 C C   . PRO B 2 8   ? 204.499 208.984 224.112 1.00 49.49 ? 9   PRO L C   1 
ATOM   1020 O O   . PRO B 2 8   ? 203.675 208.066 224.159 1.00 49.49 ? 9   PRO L O   1 
ATOM   1021 C CB  . PRO B 2 8   ? 203.157 210.480 222.570 1.00 49.49 ? 9   PRO L CB  1 
ATOM   1022 C CG  . PRO B 2 8   ? 202.629 209.513 221.584 1.00 49.49 ? 9   PRO L CG  1 
ATOM   1023 C CD  . PRO B 2 8   ? 203.787 208.814 220.917 1.00 49.49 ? 9   PRO L CD  1 
ATOM   1024 N N   . SER B 2 9   ? 205.393 209.198 225.076 1.00 50.93 ? 10  SER L N   1 
ATOM   1025 C CA  . SER B 2 9   ? 205.406 208.361 226.269 1.00 50.93 ? 10  SER L CA  1 
ATOM   1026 C C   . SER B 2 9   ? 204.253 208.701 227.204 1.00 50.93 ? 10  SER L C   1 
ATOM   1027 O O   . SER B 2 9   ? 203.609 207.802 227.754 1.00 50.93 ? 10  SER L O   1 
ATOM   1028 C CB  . SER B 2 9   ? 206.742 208.507 226.995 1.00 50.93 ? 10  SER L CB  1 
ATOM   1029 O OG  . SER B 2 9   ? 207.807 208.009 226.204 1.00 50.93 ? 10  SER L OG  1 
ATOM   1030 N N   . SER B 2 10  ? 203.985 209.987 227.397 1.00 49.88 ? 11  SER L N   1 
ATOM   1031 C CA  . SER B 2 10  ? 202.904 210.452 228.251 1.00 49.88 ? 11  SER L CA  1 
ATOM   1032 C C   . SER B 2 10  ? 202.120 211.524 227.515 1.00 49.88 ? 11  SER L C   1 
ATOM   1033 O O   . SER B 2 10  ? 202.704 212.382 226.848 1.00 49.88 ? 11  SER L O   1 
ATOM   1034 C CB  . SER B 2 10  ? 203.436 211.013 229.569 1.00 49.88 ? 11  SER L CB  1 
ATOM   1035 O OG  . SER B 2 10  ? 202.410 211.665 230.291 1.00 49.88 ? 11  SER L OG  1 
ATOM   1036 N N   . LEU B 2 11  ? 200.799 211.475 227.637 1.00 47.54 ? 12  LEU L N   1 
ATOM   1037 C CA  . LEU B 2 11  ? 199.942 212.440 226.972 1.00 47.54 ? 12  LEU L CA  1 
ATOM   1038 C C   . LEU B 2 11  ? 198.833 212.839 227.930 1.00 47.54 ? 12  LEU L C   1 
ATOM   1039 O O   . LEU B 2 11  ? 198.297 211.997 228.653 1.00 47.54 ? 12  LEU L O   1 
ATOM   1040 C CB  . LEU B 2 11  ? 199.370 211.862 225.673 1.00 47.54 ? 12  LEU L CB  1 
ATOM   1041 C CG  . LEU B 2 11  ? 198.969 212.851 224.581 1.00 47.54 ? 12  LEU L CG  1 
ATOM   1042 C CD1 . LEU B 2 11  ? 198.917 212.132 223.248 1.00 47.54 ? 12  LEU L CD1 1 
ATOM   1043 C CD2 . LEU B 2 11  ? 197.636 213.515 224.876 1.00 47.54 ? 12  LEU L CD2 1 
ATOM   1044 N N   . SER B 2 12  ? 198.496 214.122 227.936 1.00 46.71 ? 13  SER L N   1 
ATOM   1045 C CA  . SER B 2 12  ? 197.489 214.663 228.835 1.00 46.71 ? 13  SER L CA  1 
ATOM   1046 C C   . SER B 2 12  ? 196.386 215.339 228.035 1.00 46.71 ? 13  SER L C   1 
ATOM   1047 O O   . SER B 2 12  ? 196.658 216.092 227.095 1.00 46.71 ? 13  SER L O   1 
ATOM   1048 C CB  . SER B 2 12  ? 198.114 215.654 229.812 1.00 46.71 ? 13  SER L CB  1 
ATOM   1049 O OG  . SER B 2 12  ? 197.135 216.196 230.674 1.00 46.71 ? 13  SER L OG  1 
ATOM   1050 N N   . ALA B 2 13  ? 195.142 215.061 228.408 1.00 46.24 ? 14  ALA L N   1 
ATOM   1051 C CA  . ALA B 2 13  ? 193.987 215.662 227.758 1.00 46.24 ? 14  ALA L CA  1 
ATOM   1052 C C   . ALA B 2 13  ? 192.789 215.514 228.683 1.00 46.24 ? 14  ALA L C   1 
ATOM   1053 O O   . ALA B 2 13  ? 192.806 214.727 229.630 1.00 46.24 ? 14  ALA L O   1 
ATOM   1054 C CB  . ALA B 2 13  ? 193.716 215.023 226.394 1.00 46.24 ? 14  ALA L CB  1 
ATOM   1055 N N   . SER B 2 14  ? 191.747 216.283 228.400 1.00 49.59 ? 15  SER L N   1 
ATOM   1056 C CA  . SER B 2 14  ? 190.517 216.237 229.175 1.00 49.59 ? 15  SER L CA  1 
ATOM   1057 C C   . SER B 2 14  ? 189.471 215.428 228.420 1.00 49.59 ? 15  SER L C   1 
ATOM   1058 O O   . SER B 2 14  ? 189.750 214.818 227.385 1.00 49.59 ? 15  SER L O   1 
ATOM   1059 C CB  . SER B 2 14  ? 190.012 217.646 229.479 1.00 49.59 ? 15  SER L CB  1 
ATOM   1060 O OG  . SER B 2 14  ? 188.903 217.601 230.357 1.00 49.59 ? 15  SER L OG  1 
ATOM   1061 N N   . VAL B 2 15  ? 188.246 215.431 228.945 1.00 49.44 ? 16  VAL L N   1 
ATOM   1062 C CA  . VAL B 2 15  ? 187.171 214.680 228.311 1.00 49.44 ? 16  VAL L CA  1 
ATOM   1063 C C   . VAL B 2 15  ? 186.664 215.432 227.088 1.00 49.44 ? 16  VAL L C   1 
ATOM   1064 O O   . VAL B 2 15  ? 186.624 216.669 227.061 1.00 49.44 ? 16  VAL L O   1 
ATOM   1065 C CB  . VAL B 2 15  ? 186.043 214.404 229.319 1.00 49.44 ? 16  VAL L CB  1 
ATOM   1066 C CG1 . VAL B 2 15  ? 186.624 213.880 230.615 1.00 49.44 ? 16  VAL L CG1 1 
ATOM   1067 C CG2 . VAL B 2 15  ? 185.228 215.657 229.580 1.00 49.44 ? 16  VAL L CG2 1 
ATOM   1068 N N   . GLY B 2 16  ? 186.313 214.682 226.047 1.00 51.64 ? 17  GLY L N   1 
ATOM   1069 C CA  . GLY B 2 16  ? 185.718 215.240 224.854 1.00 51.64 ? 17  GLY L CA  1 
ATOM   1070 C C   . GLY B 2 16  ? 186.688 215.750 223.811 1.00 51.64 ? 17  GLY L C   1 
ATOM   1071 O O   . GLY B 2 16  ? 186.248 216.129 222.719 1.00 51.64 ? 17  GLY L O   1 
ATOM   1072 N N   . ASP B 2 17  ? 187.984 215.764 224.094 1.00 52.72 ? 18  ASP L N   1 
ATOM   1073 C CA  . ASP B 2 17  ? 188.949 216.322 223.160 1.00 52.72 ? 18  ASP L CA  1 
ATOM   1074 C C   . ASP B 2 17  ? 189.466 215.233 222.224 1.00 52.72 ? 18  ASP L C   1 
ATOM   1075 O O   . ASP B 2 17  ? 188.995 214.093 222.238 1.00 52.72 ? 18  ASP L O   1 
ATOM   1076 C CB  . ASP B 2 17  ? 190.079 217.007 223.920 1.00 52.72 ? 18  ASP L CB  1 
ATOM   1077 C CG  . ASP B 2 17  ? 189.586 217.755 225.134 1.00 52.72 ? 18  ASP L CG  1 
ATOM   1078 O OD1 . ASP B 2 17  ? 188.907 218.789 224.963 1.00 52.72 ? 18  ASP L OD1 1 
ATOM   1079 O OD2 . ASP B 2 17  ? 189.877 217.314 226.258 1.00 52.72 ? 18  ASP L OD2 1 
ATOM   1080 N N   . ARG B 2 18  ? 190.447 215.578 221.397 1.00 53.92 ? 19  ARG L N   1 
ATOM   1081 C CA  . ARG B 2 18  ? 190.994 214.671 220.399 1.00 53.92 ? 19  ARG L CA  1 
ATOM   1082 C C   . ARG B 2 18  ? 192.430 214.326 220.766 1.00 53.92 ? 19  ARG L C   1 
ATOM   1083 O O   . ARG B 2 18  ? 193.211 215.210 221.132 1.00 53.92 ? 19  ARG L O   1 
ATOM   1084 C CB  . ARG B 2 18  ? 190.936 215.299 219.008 1.00 53.92 ? 19  ARG L CB  1 
ATOM   1085 C CG  . ARG B 2 18  ? 190.774 214.304 217.877 1.00 53.92 ? 19  ARG L CG  1 
ATOM   1086 C CD  . ARG B 2 18  ? 190.185 214.983 216.655 1.00 53.92 ? 19  ARG L CD  1 
ATOM   1087 N NE  . ARG B 2 18  ? 190.195 214.112 215.488 1.00 53.92 ? 19  ARG L NE  1 
ATOM   1088 C CZ  . ARG B 2 18  ? 191.248 213.925 214.705 1.00 53.92 ? 19  ARG L CZ  1 
ATOM   1089 N NH1 . ARG B 2 18  ? 192.401 214.529 214.941 1.00 53.92 ? 19  ARG L NH1 1 
ATOM   1090 N NH2 . ARG B 2 18  ? 191.142 213.110 213.659 1.00 53.92 ? 19  ARG L NH2 1 
ATOM   1091 N N   . VAL B 2 19  ? 192.771 213.041 220.670 1.00 51.87 ? 20  VAL L N   1 
ATOM   1092 C CA  . VAL B 2 19  ? 194.080 212.538 221.061 1.00 51.87 ? 20  VAL L CA  1 
ATOM   1093 C C   . VAL B 2 19  ? 194.547 211.507 220.040 1.00 51.87 ? 20  VAL L C   1 
ATOM   1094 O O   . VAL B 2 19  ? 193.754 210.760 219.467 1.00 51.87 ? 20  VAL L O   1 
ATOM   1095 C CB  . VAL B 2 19  ? 194.050 211.945 222.485 1.00 51.87 ? 20  VAL L CB  1 
ATOM   1096 C CG1 . VAL B 2 19  ? 193.116 210.773 222.541 1.00 51.87 ? 20  VAL L CG1 1 
ATOM   1097 C CG2 . VAL B 2 19  ? 195.433 211.522 222.920 1.00 51.87 ? 20  VAL L CG2 1 
ATOM   1098 N N   . THR B 2 20  ? 195.857 211.488 219.806 1.00 50.27 ? 21  THR L N   1 
ATOM   1099 C CA  . THR B 2 20  ? 196.448 210.629 218.788 1.00 50.27 ? 21  THR L CA  1 
ATOM   1100 C C   . THR B 2 20  ? 197.726 210.010 219.333 1.00 50.27 ? 21  THR L C   1 
ATOM   1101 O O   . THR B 2 20  ? 198.530 210.701 219.962 1.00 50.27 ? 21  THR L O   1 
ATOM   1102 C CB  . THR B 2 20  ? 196.740 211.426 217.511 1.00 50.27 ? 21  THR L CB  1 
ATOM   1103 O OG1 . THR B 2 20  ? 195.513 211.694 216.823 1.00 50.27 ? 21  THR L OG1 1 
ATOM   1104 C CG2 . THR B 2 20  ? 197.674 210.660 216.588 1.00 50.27 ? 21  THR L CG2 1 
ATOM   1105 N N   . ILE B 2 21  ? 197.905 208.712 219.095 1.00 49.15 ? 22  ILE L N   1 
ATOM   1106 C CA  . ILE B 2 21  ? 199.102 207.980 219.491 1.00 49.15 ? 22  ILE L CA  1 
ATOM   1107 C C   . ILE B 2 21  ? 199.737 207.389 218.241 1.00 49.15 ? 22  ILE L C   1 
ATOM   1108 O O   . ILE B 2 21  ? 199.051 206.747 217.438 1.00 49.15 ? 22  ILE L O   1 
ATOM   1109 C CB  . ILE B 2 21  ? 198.782 206.874 220.510 1.00 49.15 ? 22  ILE L CB  1 
ATOM   1110 C CG1 . ILE B 2 21  ? 197.745 207.360 221.519 1.00 49.15 ? 22  ILE L CG1 1 
ATOM   1111 C CG2 . ILE B 2 21  ? 200.041 206.422 221.209 1.00 49.15 ? 22  ILE L CG2 1 
ATOM   1112 C CD1 . ILE B 2 21  ? 197.180 206.262 222.380 1.00 49.15 ? 22  ILE L CD1 1 
ATOM   1113 N N   . THR B 2 22  ? 201.039 207.600 218.078 1.00 51.40 ? 23  THR L N   1 
ATOM   1114 C CA  . THR B 2 22  ? 201.762 207.185 216.885 1.00 51.40 ? 23  THR L CA  1 
ATOM   1115 C C   . THR B 2 22  ? 202.710 206.034 217.201 1.00 51.40 ? 23  THR L C   1 
ATOM   1116 O O   . THR B 2 22  ? 203.179 205.886 218.331 1.00 51.40 ? 23  THR L O   1 
ATOM   1117 C CB  . THR B 2 22  ? 202.554 208.350 216.288 1.00 51.40 ? 23  THR L CB  1 
ATOM   1118 O OG1 . THR B 2 22  ? 203.794 208.498 216.990 1.00 51.40 ? 23  THR L OG1 1 
ATOM   1119 C CG2 . THR B 2 22  ? 201.761 209.641 216.396 1.00 51.40 ? 23  THR L CG2 1 
ATOM   1120 N N   . CYS B 2 23  ? 202.994 205.224 216.184 1.00 51.68 ? 24  CYS L N   1 
ATOM   1121 C CA  . CYS B 2 23  ? 203.801 204.021 216.358 1.00 51.68 ? 24  CYS L CA  1 
ATOM   1122 C C   . CYS B 2 23  ? 204.519 203.717 215.054 1.00 51.68 ? 24  CYS L C   1 
ATOM   1123 O O   . CYS B 2 23  ? 203.876 203.604 214.007 1.00 51.68 ? 24  CYS L O   1 
ATOM   1124 C CB  . CYS B 2 23  ? 202.922 202.843 216.782 1.00 51.68 ? 24  CYS L CB  1 
ATOM   1125 S SG  . CYS B 2 23  ? 203.774 201.275 216.998 1.00 51.68 ? 24  CYS L SG  1 
ATOM   1126 N N   . ARG B 2 24  ? 205.840 203.581 215.114 1.00 51.99 ? 25  ARG L N   1 
ATOM   1127 C CA  . ARG B 2 24  ? 206.660 203.320 213.942 1.00 51.99 ? 25  ARG L CA  1 
ATOM   1128 C C   . ARG B 2 24  ? 207.359 201.973 214.069 1.00 51.99 ? 25  ARG L C   1 
ATOM   1129 O O   . ARG B 2 24  ? 207.807 201.587 215.151 1.00 51.99 ? 25  ARG L O   1 
ATOM   1130 C CB  . ARG B 2 24  ? 207.707 204.417 213.740 1.00 51.99 ? 25  ARG L CB  1 
ATOM   1131 C CG  . ARG B 2 24  ? 207.153 205.827 213.794 1.00 51.99 ? 25  ARG L CG  1 
ATOM   1132 C CD  . ARG B 2 24  ? 208.153 206.828 213.235 1.00 51.99 ? 25  ARG L CD  1 
ATOM   1133 N NE  . ARG B 2 24  ? 208.101 206.903 211.780 1.00 51.99 ? 25  ARG L NE  1 
ATOM   1134 C CZ  . ARG B 2 24  ? 209.143 207.179 211.007 1.00 51.99 ? 25  ARG L CZ  1 
ATOM   1135 N NH1 . ARG B 2 24  ? 210.341 207.411 211.518 1.00 51.99 ? 25  ARG L NH1 1 
ATOM   1136 N NH2 . ARG B 2 24  ? 208.978 207.224 209.688 1.00 51.99 ? 25  ARG L NH2 1 
ATOM   1137 N N   . ALA B 2 25  ? 207.457 201.267 212.948 1.00 47.20 ? 26  ALA L N   1 
ATOM   1138 C CA  . ALA B 2 25  ? 208.106 199.967 212.891 1.00 47.20 ? 26  ALA L CA  1 
ATOM   1139 C C   . ALA B 2 25  ? 209.377 200.061 212.061 1.00 47.20 ? 26  ALA L C   1 
ATOM   1140 O O   . ALA B 2 25  ? 209.398 200.713 211.013 1.00 47.20 ? 26  ALA L O   1 
ATOM   1141 C CB  . ALA B 2 25  ? 207.174 198.909 212.300 1.00 47.20 ? 26  ALA L CB  1 
ATOM   1142 N N   . SER B 2 26  ? 210.437 199.404 212.535 1.00 45.59 ? 27  SER L N   1 
ATOM   1143 C CA  . SER B 2 26  ? 211.724 199.496 211.857 1.00 45.59 ? 27  SER L CA  1 
ATOM   1144 C C   . SER B 2 26  ? 211.699 198.819 210.498 1.00 45.59 ? 27  SER L C   1 
ATOM   1145 O O   . SER B 2 26  ? 212.388 199.258 209.573 1.00 45.59 ? 27  SER L O   1 
ATOM   1146 C CB  . SER B 2 26  ? 212.818 198.882 212.726 1.00 45.59 ? 27  SER L CB  1 
ATOM   1147 O OG  . SER B 2 26  ? 214.040 198.812 212.018 1.00 45.59 ? 27  SER L OG  1 
ATOM   1148 N N   . GLN B 2 27  ? 210.913 197.759 210.359 1.00 45.53 ? 28  GLN L N   1 
ATOM   1149 C CA  . GLN B 2 27  ? 210.886 196.942 209.159 1.00 45.53 ? 28  GLN L CA  1 
ATOM   1150 C C   . GLN B 2 27  ? 209.443 196.823 208.697 1.00 45.53 ? 28  GLN L C   1 
ATOM   1151 O O   . GLN B 2 27  ? 208.514 196.912 209.502 1.00 45.53 ? 28  GLN L O   1 
ATOM   1152 C CB  . GLN B 2 27  ? 211.505 195.567 209.440 1.00 45.53 ? 28  GLN L CB  1 
ATOM   1153 C CG  . GLN B 2 27  ? 211.459 194.583 208.311 1.00 45.53 ? 28  GLN L CG  1 
ATOM   1154 C CD  . GLN B 2 27  ? 212.286 193.359 208.603 1.00 45.53 ? 28  GLN L CD  1 
ATOM   1155 O OE1 . GLN B 2 27  ? 213.483 193.453 208.857 1.00 45.53 ? 28  GLN L OE1 1 
ATOM   1156 N NE2 . GLN B 2 27  ? 211.649 192.198 208.580 1.00 45.53 ? 28  GLN L NE2 1 
ATOM   1157 N N   . SER B 2 28  ? 209.260 196.639 207.394 1.00 44.04 ? 29  SER L N   1 
ATOM   1158 C CA  . SER B 2 28  ? 207.923 196.669 206.819 1.00 44.04 ? 29  SER L CA  1 
ATOM   1159 C C   . SER B 2 28  ? 207.062 195.541 207.367 1.00 44.04 ? 29  SER L C   1 
ATOM   1160 O O   . SER B 2 28  ? 207.417 194.365 207.263 1.00 44.04 ? 29  SER L O   1 
ATOM   1161 C CB  . SER B 2 28  ? 208.005 196.576 205.299 1.00 44.04 ? 29  SER L CB  1 
ATOM   1162 O OG  . SER B 2 28  ? 206.742 196.240 204.755 1.00 44.04 ? 29  SER L OG  1 
ATOM   1163 N N   . VAL B 2 29  ? 205.929 195.910 207.955 1.00 42.46 ? 30  VAL L N   1 
ATOM   1164 C CA  . VAL B 2 29  ? 204.870 194.978 208.317 1.00 42.46 ? 30  VAL L CA  1 
ATOM   1165 C C   . VAL B 2 29  ? 203.612 195.445 207.599 1.00 42.46 ? 30  VAL L C   1 
ATOM   1166 O O   . VAL B 2 29  ? 203.207 196.606 207.733 1.00 42.46 ? 30  VAL L O   1 
ATOM   1167 C CB  . VAL B 2 29  ? 204.659 194.906 209.836 1.00 42.46 ? 30  VAL L CB  1 
ATOM   1168 C CG1 . VAL B 2 29  ? 205.765 194.096 210.473 1.00 42.46 ? 30  VAL L CG1 1 
ATOM   1169 C CG2 . VAL B 2 29  ? 204.621 196.292 210.444 1.00 42.46 ? 30  VAL L CG2 1 
ATOM   1170 N N   . SER B 2 30  ? 203.008 194.552 206.823 1.00 45.48 ? 31  SER L N   1 
ATOM   1171 C CA  . SER B 2 30  ? 201.918 194.925 205.924 1.00 45.48 ? 31  SER L CA  1 
ATOM   1172 C C   . SER B 2 30  ? 200.603 194.918 206.692 1.00 45.48 ? 31  SER L C   1 
ATOM   1173 O O   . SER B 2 30  ? 199.820 193.968 206.646 1.00 45.48 ? 31  SER L O   1 
ATOM   1174 C CB  . SER B 2 30  ? 201.877 193.987 204.731 1.00 45.48 ? 31  SER L CB  1 
ATOM   1175 O OG  . SER B 2 30  ? 202.076 192.656 205.159 1.00 45.48 ? 31  SER L OG  1 
ATOM   1176 N N   . SER B 2 31  ? 200.366 196.013 207.411 1.00 44.16 ? 32  SER L N   1 
ATOM   1177 C CA  . SER B 2 31  ? 199.143 196.203 208.186 1.00 44.16 ? 32  SER L CA  1 
ATOM   1178 C C   . SER B 2 31  ? 198.949 195.100 209.219 1.00 44.16 ? 32  SER L C   1 
ATOM   1179 O O   . SER B 2 31  ? 197.823 194.793 209.608 1.00 44.16 ? 32  SER L O   1 
ATOM   1180 C CB  . SER B 2 31  ? 197.916 196.301 207.277 1.00 44.16 ? 32  SER L CB  1 
ATOM   1181 O OG  . SER B 2 31  ? 197.499 195.015 206.859 1.00 44.16 ? 32  SER L OG  1 
ATOM   1182 N N   . ALA B 2 32  ? 200.037 194.487 209.667 1.00 43.71 ? 33  ALA L N   1 
ATOM   1183 C CA  . ALA B 2 32  ? 199.973 193.486 210.729 1.00 43.71 ? 33  ALA L CA  1 
ATOM   1184 C C   . ALA B 2 32  ? 200.296 194.118 212.082 1.00 43.71 ? 33  ALA L C   1 
ATOM   1185 O O   . ALA B 2 32  ? 201.212 193.708 212.789 1.00 43.71 ? 33  ALA L O   1 
ATOM   1186 C CB  . ALA B 2 32  ? 200.913 192.327 210.417 1.00 43.71 ? 33  ALA L CB  1 
ATOM   1187 N N   . VAL B 2 33  ? 199.523 195.145 212.435 1.00 41.95 ? 34  VAL L N   1 
ATOM   1188 C CA  . VAL B 2 33  ? 199.697 195.888 213.678 1.00 41.95 ? 34  VAL L CA  1 
ATOM   1189 C C   . VAL B 2 33  ? 198.359 196.035 214.384 1.00 41.95 ? 34  VAL L C   1 
ATOM   1190 O O   . VAL B 2 33  ? 197.343 196.350 213.756 1.00 41.95 ? 34  VAL L O   1 
ATOM   1191 C CB  . VAL B 2 33  ? 200.337 197.267 213.439 1.00 41.95 ? 34  VAL L CB  1 
ATOM   1192 C CG1 . VAL B 2 33  ? 200.829 197.841 214.740 1.00 41.95 ? 34  VAL L CG1 1 
ATOM   1193 C CG2 . VAL B 2 33  ? 201.509 197.119 212.509 1.00 41.95 ? 34  VAL L CG2 1 
ATOM   1194 N N   . ALA B 2 34  ? 198.363 195.806 215.695 1.00 41.33 ? 35  ALA L N   1 
ATOM   1195 C CA  . ALA B 2 34  ? 197.162 195.862 216.510 1.00 41.33 ? 35  ALA L CA  1 
ATOM   1196 C C   . ALA B 2 34  ? 197.383 196.776 217.705 1.00 41.33 ? 35  ALA L C   1 
ATOM   1197 O O   . ALA B 2 34  ? 198.500 196.909 218.210 1.00 41.33 ? 35  ALA L O   1 
ATOM   1198 C CB  . ALA B 2 34  ? 196.750 194.470 216.995 1.00 41.33 ? 35  ALA L CB  1 
ATOM   1199 N N   . TRP B 2 35  ? 196.301 197.400 218.156 1.00 42.33 ? 36  TRP L N   1 
ATOM   1200 C CA  . TRP B 2 35  ? 196.319 198.307 219.291 1.00 42.33 ? 36  TRP L CA  1 
ATOM   1201 C C   . TRP B 2 35  ? 195.557 197.690 220.453 1.00 42.33 ? 36  TRP L C   1 
ATOM   1202 O O   . TRP B 2 35  ? 194.480 197.119 220.266 1.00 42.33 ? 36  TRP L O   1 
ATOM   1203 C CB  . TRP B 2 35  ? 195.696 199.654 218.927 1.00 42.33 ? 36  TRP L CB  1 
ATOM   1204 C CG  . TRP B 2 35  ? 196.439 200.420 217.880 1.00 42.33 ? 36  TRP L CG  1 
ATOM   1205 C CD1 . TRP B 2 35  ? 196.194 200.425 216.542 1.00 42.33 ? 36  TRP L CD1 1 
ATOM   1206 C CD2 . TRP B 2 35  ? 197.538 201.313 218.089 1.00 42.33 ? 36  TRP L CD2 1 
ATOM   1207 N NE1 . TRP B 2 35  ? 197.078 201.258 215.902 1.00 42.33 ? 36  TRP L NE1 1 
ATOM   1208 C CE2 . TRP B 2 35  ? 197.911 201.817 216.833 1.00 42.33 ? 36  TRP L CE2 1 
ATOM   1209 C CE3 . TRP B 2 35  ? 198.244 201.731 219.218 1.00 42.33 ? 36  TRP L CE3 1 
ATOM   1210 C CZ2 . TRP B 2 35  ? 198.958 202.710 216.673 1.00 42.33 ? 36  TRP L CZ2 1 
ATOM   1211 C CZ3 . TRP B 2 35  ? 199.279 202.618 219.057 1.00 42.33 ? 36  TRP L CZ3 1 
ATOM   1212 C CH2 . TRP B 2 35  ? 199.627 203.101 217.796 1.00 42.33 ? 36  TRP L CH2 1 
ATOM   1213 N N   . TYR B 2 36  ? 196.113 197.820 221.654 1.00 41.35 ? 37  TYR L N   1 
ATOM   1214 C CA  . TYR B 2 36  ? 195.500 197.296 222.863 1.00 41.35 ? 37  TYR L CA  1 
ATOM   1215 C C   . TYR B 2 36  ? 195.303 198.408 223.883 1.00 41.35 ? 37  TYR L C   1 
ATOM   1216 O O   . TYR B 2 36  ? 195.952 199.454 223.830 1.00 41.35 ? 37  TYR L O   1 
ATOM   1217 C CB  . TYR B 2 36  ? 196.343 196.178 223.480 1.00 41.35 ? 37  TYR L CB  1 
ATOM   1218 C CG  . TYR B 2 36  ? 196.414 194.949 222.621 1.00 41.35 ? 37  TYR L CG  1 
ATOM   1219 C CD1 . TYR B 2 36  ? 197.379 194.828 221.641 1.00 41.35 ? 37  TYR L CD1 1 
ATOM   1220 C CD2 . TYR B 2 36  ? 195.518 193.913 222.787 1.00 41.35 ? 37  TYR L CD2 1 
ATOM   1221 C CE1 . TYR B 2 36  ? 197.445 193.715 220.852 1.00 41.35 ? 37  TYR L CE1 1 
ATOM   1222 C CE2 . TYR B 2 36  ? 195.578 192.793 222.001 1.00 41.35 ? 37  TYR L CE2 1 
ATOM   1223 C CZ  . TYR B 2 36  ? 196.543 192.700 221.035 1.00 41.35 ? 37  TYR L CZ  1 
ATOM   1224 O OH  . TYR B 2 36  ? 196.615 191.587 220.240 1.00 41.35 ? 37  TYR L OH  1 
ATOM   1225 N N   . GLN B 2 37  ? 194.385 198.170 224.811 1.00 42.25 ? 38  GLN L N   1 
ATOM   1226 C CA  . GLN B 2 37  ? 194.103 199.091 225.900 1.00 42.25 ? 38  GLN L CA  1 
ATOM   1227 C C   . GLN B 2 37  ? 194.151 198.320 227.204 1.00 42.25 ? 38  GLN L C   1 
ATOM   1228 O O   . GLN B 2 37  ? 193.497 197.281 227.333 1.00 42.25 ? 38  GLN L O   1 
ATOM   1229 C CB  . GLN B 2 37  ? 192.736 199.748 225.728 1.00 42.25 ? 38  GLN L CB  1 
ATOM   1230 C CG  . GLN B 2 37  ? 192.156 200.310 227.002 1.00 42.25 ? 38  GLN L CG  1 
ATOM   1231 C CD  . GLN B 2 37  ? 190.774 200.874 226.798 1.00 42.25 ? 38  GLN L CD  1 
ATOM   1232 O OE1 . GLN B 2 37  ? 189.798 200.135 226.716 1.00 42.25 ? 38  GLN L OE1 1 
ATOM   1233 N NE2 . GLN B 2 37  ? 190.681 202.192 226.713 1.00 42.25 ? 38  GLN L NE2 1 
ATOM   1234 N N   . GLN B 2 38  ? 194.920 198.819 228.167 1.00 42.17 ? 39  GLN L N   1 
ATOM   1235 C CA  . GLN B 2 38  ? 195.113 198.114 229.429 1.00 42.17 ? 39  GLN L CA  1 
ATOM   1236 C C   . GLN B 2 38  ? 194.877 199.066 230.591 1.00 42.17 ? 39  GLN L C   1 
ATOM   1237 O O   . GLN B 2 38  ? 195.709 199.934 230.872 1.00 42.17 ? 39  GLN L O   1 
ATOM   1238 C CB  . GLN B 2 38  ? 196.504 197.497 229.518 1.00 42.17 ? 39  GLN L CB  1 
ATOM   1239 C CG  . GLN B 2 38  ? 196.786 196.890 230.877 1.00 42.17 ? 39  GLN L CG  1 
ATOM   1240 C CD  . GLN B 2 38  ? 197.937 195.922 230.861 1.00 42.17 ? 39  GLN L CD  1 
ATOM   1241 O OE1 . GLN B 2 38  ? 197.740 194.710 230.850 1.00 42.17 ? 39  GLN L OE1 1 
ATOM   1242 N NE2 . GLN B 2 38  ? 199.153 196.449 230.863 1.00 42.17 ? 39  GLN L NE2 1 
ATOM   1243 N N   . LYS B 2 39  ? 193.746 198.895 231.262 1.00 43.81 ? 40  LYS L N   1 
ATOM   1244 C CA  . LYS B 2 39  ? 193.477 199.599 232.493 1.00 43.81 ? 40  LYS L CA  1 
ATOM   1245 C C   . LYS B 2 39  ? 194.396 199.069 233.590 1.00 43.81 ? 40  LYS L C   1 
ATOM   1246 O O   . LYS B 2 39  ? 194.914 197.955 233.488 1.00 43.81 ? 40  LYS L O   1 
ATOM   1247 C CB  . LYS B 2 39  ? 192.010 199.423 232.877 1.00 43.81 ? 40  LYS L CB  1 
ATOM   1248 C CG  . LYS B 2 39  ? 191.064 200.311 232.092 1.00 43.81 ? 40  LYS L CG  1 
ATOM   1249 C CD  . LYS B 2 39  ? 189.627 199.856 232.244 1.00 43.81 ? 40  LYS L CD  1 
ATOM   1250 C CE  . LYS B 2 39  ? 188.671 200.885 231.673 1.00 43.81 ? 40  LYS L CE  1 
ATOM   1251 N NZ  . LYS B 2 39  ? 189.388 201.902 230.857 1.00 43.81 ? 40  LYS L NZ  1 
ATOM   1252 N N   . PRO B 2 40  ? 194.630 199.850 234.646 1.00 45.97 ? 41  PRO L N   1 
ATOM   1253 C CA  . PRO B 2 40  ? 195.519 199.367 235.711 1.00 45.97 ? 41  PRO L CA  1 
ATOM   1254 C C   . PRO B 2 40  ? 194.917 198.209 236.491 1.00 45.97 ? 41  PRO L C   1 
ATOM   1255 O O   . PRO B 2 40  ? 193.927 198.380 237.208 1.00 45.97 ? 41  PRO L O   1 
ATOM   1256 C CB  . PRO B 2 40  ? 195.725 200.596 236.607 1.00 45.97 ? 41  PRO L CB  1 
ATOM   1257 C CG  . PRO B 2 40  ? 194.725 201.595 236.195 1.00 45.97 ? 41  PRO L CG  1 
ATOM   1258 C CD  . PRO B 2 40  ? 194.042 201.166 234.943 1.00 45.97 ? 41  PRO L CD  1 
ATOM   1259 N N   . GLY B 2 41  ? 195.510 197.028 236.358 1.00 42.86 ? 42  GLY L N   1 
ATOM   1260 C CA  . GLY B 2 41  ? 195.079 195.867 237.101 1.00 42.86 ? 42  GLY L CA  1 
ATOM   1261 C C   . GLY B 2 41  ? 194.226 194.874 236.349 1.00 42.86 ? 42  GLY L C   1 
ATOM   1262 O O   . GLY B 2 41  ? 193.719 193.934 236.970 1.00 42.86 ? 42  GLY L O   1 
ATOM   1263 N N   . LYS B 2 42  ? 194.050 195.041 235.046 1.00 42.56 ? 43  LYS L N   1 
ATOM   1264 C CA  . LYS B 2 42  ? 193.219 194.155 234.247 1.00 42.56 ? 43  LYS L CA  1 
ATOM   1265 C C   . LYS B 2 42  ? 194.028 193.584 233.088 1.00 42.56 ? 43  LYS L C   1 
ATOM   1266 O O   . LYS B 2 42  ? 195.223 193.844 232.941 1.00 42.56 ? 43  LYS L O   1 
ATOM   1267 C CB  . LYS B 2 42  ? 191.977 194.890 233.734 1.00 42.56 ? 43  LYS L CB  1 
ATOM   1268 C CG  . LYS B 2 42  ? 190.838 194.942 234.734 1.00 42.56 ? 43  LYS L CG  1 
ATOM   1269 C CD  . LYS B 2 42  ? 190.258 193.559 234.977 1.00 42.56 ? 43  LYS L CD  1 
ATOM   1270 C CE  . LYS B 2 42  ? 189.389 193.536 236.222 1.00 42.56 ? 43  LYS L CE  1 
ATOM   1271 N NZ  . LYS B 2 42  ? 190.206 193.552 237.464 1.00 42.56 ? 43  LYS L NZ  1 
ATOM   1272 N N   . ALA B 2 43  ? 193.359 192.791 232.267 1.00 41.46 ? 44  ALA L N   1 
ATOM   1273 C CA  . ALA B 2 43  ? 193.971 192.201 231.093 1.00 41.46 ? 44  ALA L CA  1 
ATOM   1274 C C   . ALA B 2 43  ? 193.958 193.184 229.929 1.00 41.46 ? 44  ALA L C   1 
ATOM   1275 O O   . ALA B 2 43  ? 193.127 194.093 229.880 1.00 41.46 ? 44  ALA L O   1 
ATOM   1276 C CB  . ALA B 2 43  ? 193.233 190.926 230.708 1.00 41.46 ? 44  ALA L CB  1 
ATOM   1277 N N   . PRO B 2 44  ? 194.878 193.031 228.982 1.00 38.81 ? 45  PRO L N   1 
ATOM   1278 C CA  . PRO B 2 44  ? 194.834 193.866 227.780 1.00 38.81 ? 45  PRO L CA  1 
ATOM   1279 C C   . PRO B 2 44  ? 193.623 193.536 226.921 1.00 38.81 ? 45  PRO L C   1 
ATOM   1280 O O   . PRO B 2 44  ? 193.108 192.417 226.937 1.00 38.81 ? 45  PRO L O   1 
ATOM   1281 C CB  . PRO B 2 44  ? 196.141 193.522 227.059 1.00 38.81 ? 45  PRO L CB  1 
ATOM   1282 C CG  . PRO B 2 44  ? 196.997 192.873 228.095 1.00 38.81 ? 45  PRO L CG  1 
ATOM   1283 C CD  . PRO B 2 44  ? 196.060 192.159 228.997 1.00 38.81 ? 45  PRO L CD  1 
ATOM   1284 N N   . LYS B 2 45  ? 193.163 194.534 226.169 1.00 39.51 ? 46  LYS L N   1 
ATOM   1285 C CA  . LYS B 2 45  ? 191.986 194.391 225.321 1.00 39.51 ? 46  LYS L CA  1 
ATOM   1286 C C   . LYS B 2 45  ? 192.299 194.866 223.912 1.00 39.51 ? 46  LYS L C   1 
ATOM   1287 O O   . LYS B 2 45  ? 192.818 195.969 223.729 1.00 39.51 ? 46  LYS L O   1 
ATOM   1288 C CB  . LYS B 2 45  ? 190.803 195.177 225.883 1.00 39.51 ? 46  LYS L CB  1 
ATOM   1289 C CG  . LYS B 2 45  ? 190.110 194.499 227.039 1.00 39.51 ? 46  LYS L CG  1 
ATOM   1290 C CD  . LYS B 2 45  ? 188.695 195.008 227.200 1.00 39.51 ? 46  LYS L CD  1 
ATOM   1291 C CE  . LYS B 2 45  ? 187.998 194.315 228.355 1.00 39.51 ? 46  LYS L CE  1 
ATOM   1292 N NZ  . LYS B 2 45  ? 187.818 192.863 228.096 1.00 39.51 ? 46  LYS L NZ  1 
ATOM   1293 N N   . LEU B 2 46  ? 191.971 194.040 222.921 1.00 39.31 ? 47  LEU L N   1 
ATOM   1294 C CA  . LEU B 2 46  ? 192.216 194.385 221.528 1.00 39.31 ? 47  LEU L CA  1 
ATOM   1295 C C   . LEU B 2 46  ? 191.197 195.410 221.059 1.00 39.31 ? 47  LEU L C   1 
ATOM   1296 O O   . LEU B 2 46  ? 190.000 195.268 221.315 1.00 39.31 ? 47  LEU L O   1 
ATOM   1297 C CB  . LEU B 2 46  ? 192.151 193.140 220.649 1.00 39.31 ? 47  LEU L CB  1 
ATOM   1298 C CG  . LEU B 2 46  ? 192.154 193.345 219.135 1.00 39.31 ? 47  LEU L CG  1 
ATOM   1299 C CD1 . LEU B 2 46  ? 193.352 194.170 218.700 1.00 39.31 ? 47  LEU L CD1 1 
ATOM   1300 C CD2 . LEU B 2 46  ? 192.150 192.010 218.419 1.00 39.31 ? 47  LEU L CD2 1 
ATOM   1301 N N   . LEU B 2 47  ? 191.676 196.439 220.362 1.00 40.74 ? 48  LEU L N   1 
ATOM   1302 C CA  . LEU B 2 47  ? 190.834 197.520 219.865 1.00 40.74 ? 48  LEU L CA  1 
ATOM   1303 C C   . LEU B 2 47  ? 190.771 197.545 218.344 1.00 40.74 ? 48  LEU L C   1 
ATOM   1304 O O   . LEU B 2 47  ? 189.689 197.436 217.767 1.00 40.74 ? 48  LEU L O   1 
ATOM   1305 C CB  . LEU B 2 47  ? 191.356 198.863 220.397 1.00 40.74 ? 48  LEU L CB  1 
ATOM   1306 C CG  . LEU B 2 47  ? 190.771 199.445 221.683 1.00 40.74 ? 48  LEU L CG  1 
ATOM   1307 C CD1 . LEU B 2 47  ? 190.678 198.404 222.777 1.00 40.74 ? 48  LEU L CD1 1 
ATOM   1308 C CD2 . LEU B 2 47  ? 191.623 200.611 222.145 1.00 40.74 ? 48  LEU L CD2 1 
ATOM   1309 N N   . ILE B 2 48  ? 191.910 197.684 217.672 1.00 39.83 ? 49  ILE L N   1 
ATOM   1310 C CA  . ILE B 2 48  ? 191.977 197.724 216.217 1.00 39.83 ? 49  ILE L CA  1 
ATOM   1311 C C   . ILE B 2 48  ? 192.913 196.617 215.762 1.00 39.83 ? 49  ILE L C   1 
ATOM   1312 O O   . ILE B 2 48  ? 194.095 196.613 216.121 1.00 39.83 ? 49  ILE L O   1 
ATOM   1313 C CB  . ILE B 2 48  ? 192.465 199.083 215.682 1.00 39.83 ? 49  ILE L CB  1 
ATOM   1314 C CG1 . ILE B 2 48  ? 192.100 200.268 216.588 1.00 39.83 ? 49  ILE L CG1 1 
ATOM   1315 C CG2 . ILE B 2 48  ? 191.912 199.333 214.295 1.00 39.83 ? 49  ILE L CG2 1 
ATOM   1316 C CD1 . ILE B 2 48  ? 190.620 200.426 216.898 1.00 39.83 ? 49  ILE L CD1 1 
ATOM   1317 N N   . TYR B 2 49  ? 192.397 195.690 214.966 1.00 40.25 ? 50  TYR L N   1 
ATOM   1318 C CA  . TYR B 2 49  ? 193.220 194.661 214.351 1.00 40.25 ? 50  TYR L CA  1 
ATOM   1319 C C   . TYR B 2 49  ? 193.374 194.956 212.868 1.00 40.25 ? 50  TYR L C   1 
ATOM   1320 O O   . TYR B 2 49  ? 192.491 195.548 212.244 1.00 40.25 ? 50  TYR L O   1 
ATOM   1321 C CB  . TYR B 2 49  ? 192.630 193.265 214.563 1.00 40.25 ? 50  TYR L CB  1 
ATOM   1322 C CG  . TYR B 2 49  ? 191.306 193.015 213.892 1.00 40.25 ? 50  TYR L CG  1 
ATOM   1323 C CD1 . TYR B 2 49  ? 190.131 193.511 214.426 1.00 40.25 ? 50  TYR L CD1 1 
ATOM   1324 C CD2 . TYR B 2 49  ? 191.230 192.259 212.735 1.00 40.25 ? 50  TYR L CD2 1 
ATOM   1325 C CE1 . TYR B 2 49  ? 188.919 193.271 213.817 1.00 40.25 ? 50  TYR L CE1 1 
ATOM   1326 C CE2 . TYR B 2 49  ? 190.026 192.018 212.121 1.00 40.25 ? 50  TYR L CE2 1 
ATOM   1327 C CZ  . TYR B 2 49  ? 188.874 192.522 212.665 1.00 40.25 ? 50  TYR L CZ  1 
ATOM   1328 O OH  . TYR B 2 49  ? 187.669 192.280 212.050 1.00 40.25 ? 50  TYR L OH  1 
ATOM   1329 N N   . SER B 2 50  ? 194.519 194.563 212.316 1.00 40.83 ? 51  SER L N   1 
ATOM   1330 C CA  . SER B 2 50  ? 194.918 194.918 210.958 1.00 40.83 ? 51  SER L CA  1 
ATOM   1331 C C   . SER B 2 50  ? 195.052 196.423 210.783 1.00 40.83 ? 51  SER L C   1 
ATOM   1332 O O   . SER B 2 50  ? 194.956 196.930 209.662 1.00 40.83 ? 51  SER L O   1 
ATOM   1333 C CB  . SER B 2 50  ? 193.952 194.343 209.918 1.00 40.83 ? 51  SER L CB  1 
ATOM   1334 O OG  . SER B 2 50  ? 194.374 194.654 208.604 1.00 40.83 ? 51  SER L OG  1 
ATOM   1335 N N   . ALA B 2 51  ? 195.238 197.140 211.889 1.00 42.10 ? 52  ALA L N   1 
ATOM   1336 C CA  . ALA B 2 51  ? 195.566 198.563 211.915 1.00 42.10 ? 52  ALA L CA  1 
ATOM   1337 C C   . ALA B 2 51  ? 194.420 199.446 211.438 1.00 42.10 ? 52  ALA L C   1 
ATOM   1338 O O   . ALA B 2 51  ? 194.515 200.674 211.507 1.00 42.10 ? 52  ALA L O   1 
ATOM   1339 C CB  . ALA B 2 51  ? 196.817 198.843 211.080 1.00 42.10 ? 52  ALA L CB  1 
ATOM   1340 N N   . SER B 2 52  ? 193.337 198.844 210.954 1.00 42.14 ? 53  SER L N   1 
ATOM   1341 C CA  . SER B 2 52  ? 192.200 199.630 210.498 1.00 42.14 ? 53  SER L CA  1 
ATOM   1342 C C   . SER B 2 52  ? 190.846 199.055 210.871 1.00 42.14 ? 53  SER L C   1 
ATOM   1343 O O   . SER B 2 52  ? 189.857 199.788 210.789 1.00 42.14 ? 53  SER L O   1 
ATOM   1344 C CB  . SER B 2 52  ? 192.256 199.807 208.975 1.00 42.14 ? 53  SER L CB  1 
ATOM   1345 O OG  . SER B 2 52  ? 192.144 198.559 208.315 1.00 42.14 ? 53  SER L OG  1 
ATOM   1346 N N   . SER B 2 53  ? 190.753 197.795 211.273 1.00 40.05 ? 54  SER L N   1 
ATOM   1347 C CA  . SER B 2 53  ? 189.469 197.155 211.507 1.00 40.05 ? 54  SER L CA  1 
ATOM   1348 C C   . SER B 2 53  ? 189.153 197.180 212.992 1.00 40.05 ? 54  SER L C   1 
ATOM   1349 O O   . SER B 2 53  ? 189.988 196.793 213.816 1.00 40.05 ? 54  SER L O   1 
ATOM   1350 C CB  . SER B 2 53  ? 189.472 195.718 210.992 1.00 40.05 ? 54  SER L CB  1 
ATOM   1351 O OG  . SER B 2 53  ? 189.550 195.686 209.578 1.00 40.05 ? 54  SER L OG  1 
ATOM   1352 N N   . LEU B 2 54  ? 187.949 197.622 213.327 1.00 40.44 ? 55  LEU L N   1 
ATOM   1353 C CA  . LEU B 2 54  ? 187.525 197.684 214.717 1.00 40.44 ? 55  LEU L CA  1 
ATOM   1354 C C   . LEU B 2 54  ? 186.978 196.329 215.147 1.00 40.44 ? 55  LEU L C   1 
ATOM   1355 O O   . LEU B 2 54  ? 186.061 195.792 214.519 1.00 40.44 ? 55  LEU L O   1 
ATOM   1356 C CB  . LEU B 2 54  ? 186.476 198.776 214.901 1.00 40.44 ? 55  LEU L CB  1 
ATOM   1357 C CG  . LEU B 2 54  ? 186.063 199.065 216.341 1.00 40.44 ? 55  LEU L CG  1 
ATOM   1358 C CD1 . LEU B 2 54  ? 186.680 200.366 216.825 1.00 40.44 ? 55  LEU L CD1 1 
ATOM   1359 C CD2 . LEU B 2 54  ? 184.553 199.110 216.455 1.00 40.44 ? 55  LEU L CD2 1 
ATOM   1360 N N   . TYR B 2 55  ? 187.544 195.781 216.217 1.00 42.37 ? 56  TYR L N   1 
ATOM   1361 C CA  . TYR B 2 55  ? 187.083 194.518 216.769 1.00 42.37 ? 56  TYR L CA  1 
ATOM   1362 C C   . TYR B 2 55  ? 185.657 194.662 217.293 1.00 42.37 ? 56  TYR L C   1 
ATOM   1363 O O   . TYR B 2 55  ? 185.188 195.758 217.608 1.00 42.37 ? 56  TYR L O   1 
ATOM   1364 C CB  . TYR B 2 55  ? 188.027 194.066 217.884 1.00 42.37 ? 56  TYR L CB  1 
ATOM   1365 C CG  . TYR B 2 55  ? 187.820 192.658 218.389 1.00 42.37 ? 56  TYR L CG  1 
ATOM   1366 C CD1 . TYR B 2 55  ? 188.138 191.566 217.606 1.00 42.37 ? 56  TYR L CD1 1 
ATOM   1367 C CD2 . TYR B 2 55  ? 187.328 192.426 219.660 1.00 42.37 ? 56  TYR L CD2 1 
ATOM   1368 C CE1 . TYR B 2 55  ? 187.960 190.285 218.070 1.00 42.37 ? 56  TYR L CE1 1 
ATOM   1369 C CE2 . TYR B 2 55  ? 187.145 191.150 220.131 1.00 42.37 ? 56  TYR L CE2 1 
ATOM   1370 C CZ  . TYR B 2 55  ? 187.462 190.082 219.333 1.00 42.37 ? 56  TYR L CZ  1 
ATOM   1371 O OH  . TYR B 2 55  ? 187.279 188.803 219.802 1.00 42.37 ? 56  TYR L OH  1 
ATOM   1372 N N   . SER B 2 56  ? 184.959 193.531 217.372 1.00 45.77 ? 57  SER L N   1 
ATOM   1373 C CA  . SER B 2 56  ? 183.576 193.535 217.830 1.00 45.77 ? 57  SER L CA  1 
ATOM   1374 C C   . SER B 2 56  ? 183.488 193.976 219.284 1.00 45.77 ? 57  SER L C   1 
ATOM   1375 O O   . SER B 2 56  ? 184.312 193.594 220.119 1.00 45.77 ? 57  SER L O   1 
ATOM   1376 C CB  . SER B 2 56  ? 182.963 192.146 217.671 1.00 45.77 ? 57  SER L CB  1 
ATOM   1377 O OG  . SER B 2 56  ? 183.043 191.705 216.327 1.00 45.77 ? 57  SER L OG  1 
ATOM   1378 N N   . GLY B 2 57  ? 182.477 194.789 219.584 1.00 46.49 ? 58  GLY L N   1 
ATOM   1379 C CA  . GLY B 2 57  ? 182.220 195.265 220.922 1.00 46.49 ? 58  GLY L CA  1 
ATOM   1380 C C   . GLY B 2 57  ? 182.854 196.601 221.254 1.00 46.49 ? 58  GLY L C   1 
ATOM   1381 O O   . GLY B 2 57  ? 182.287 197.366 222.039 1.00 46.49 ? 58  GLY L O   1 
ATOM   1382 N N   . VAL B 2 58  ? 184.013 196.897 220.675 1.00 45.39 ? 59  VAL L N   1 
ATOM   1383 C CA  . VAL B 2 58  ? 184.702 198.156 220.975 1.00 45.39 ? 59  VAL L CA  1 
ATOM   1384 C C   . VAL B 2 58  ? 183.852 199.320 220.485 1.00 45.39 ? 59  VAL L C   1 
ATOM   1385 O O   . VAL B 2 58  ? 183.235 199.221 219.405 1.00 45.39 ? 59  VAL L O   1 
ATOM   1386 C CB  . VAL B 2 58  ? 186.093 198.174 220.321 1.00 45.39 ? 59  VAL L CB  1 
ATOM   1387 C CG1 . VAL B 2 58  ? 186.831 199.456 220.651 1.00 45.39 ? 59  VAL L CG1 1 
ATOM   1388 C CG2 . VAL B 2 58  ? 186.897 196.971 220.768 1.00 45.39 ? 59  VAL L CG2 1 
ATOM   1389 N N   . PRO B 2 59  ? 183.755 200.422 221.226 1.00 47.68 ? 60  PRO L N   1 
ATOM   1390 C CA  . PRO B 2 59  ? 183.002 201.585 220.739 1.00 47.68 ? 60  PRO L CA  1 
ATOM   1391 C C   . PRO B 2 59  ? 183.586 202.134 219.446 1.00 47.68 ? 60  PRO L C   1 
ATOM   1392 O O   . PRO B 2 59  ? 184.711 201.830 219.048 1.00 47.68 ? 60  PRO L O   1 
ATOM   1393 C CB  . PRO B 2 59  ? 183.127 202.591 221.885 1.00 47.68 ? 60  PRO L CB  1 
ATOM   1394 C CG  . PRO B 2 59  ? 183.332 201.747 223.095 1.00 47.68 ? 60  PRO L CG  1 
ATOM   1395 C CD  . PRO B 2 59  ? 184.132 200.561 222.642 1.00 47.68 ? 60  PRO L CD  1 
ATOM   1396 N N   . SER B 2 60  ? 182.791 202.972 218.785 1.00 47.94 ? 61  SER L N   1 
ATOM   1397 C CA  . SER B 2 60  ? 183.084 203.432 217.435 1.00 47.94 ? 61  SER L CA  1 
ATOM   1398 C C   . SER B 2 60  ? 183.869 204.738 217.390 1.00 47.94 ? 61  SER L C   1 
ATOM   1399 O O   . SER B 2 60  ? 184.059 205.289 216.302 1.00 47.94 ? 61  SER L O   1 
ATOM   1400 C CB  . SER B 2 60  ? 181.786 203.592 216.643 1.00 47.94 ? 61  SER L CB  1 
ATOM   1401 O OG  . SER B 2 60  ? 182.054 203.804 215.268 1.00 47.94 ? 61  SER L OG  1 
ATOM   1402 N N   . ARG B 2 61  ? 184.321 205.249 218.531 1.00 49.15 ? 62  ARG L N   1 
ATOM   1403 C CA  . ARG B 2 61  ? 185.123 206.465 218.557 1.00 49.15 ? 62  ARG L CA  1 
ATOM   1404 C C   . ARG B 2 61  ? 186.604 206.199 218.337 1.00 49.15 ? 62  ARG L C   1 
ATOM   1405 O O   . ARG B 2 61  ? 187.395 207.147 218.336 1.00 49.15 ? 62  ARG L O   1 
ATOM   1406 C CB  . ARG B 2 61  ? 184.924 207.209 219.882 1.00 49.15 ? 62  ARG L CB  1 
ATOM   1407 C CG  . ARG B 2 61  ? 185.420 206.454 221.095 1.00 49.15 ? 62  ARG L CG  1 
ATOM   1408 C CD  . ARG B 2 61  ? 185.183 207.233 222.377 1.00 49.15 ? 62  ARG L CD  1 
ATOM   1409 N NE  . ARG B 2 61  ? 185.003 206.344 223.519 1.00 49.15 ? 62  ARG L NE  1 
ATOM   1410 C CZ  . ARG B 2 61  ? 183.899 205.654 223.767 1.00 49.15 ? 62  ARG L CZ  1 
ATOM   1411 N NH1 . ARG B 2 61  ? 182.837 205.746 222.985 1.00 49.15 ? 62  ARG L NH1 1 
ATOM   1412 N NH2 . ARG B 2 61  ? 183.859 204.852 224.826 1.00 49.15 ? 62  ARG L NH2 1 
ATOM   1413 N N   . PHE B 2 62  ? 186.996 204.942 218.158 1.00 47.39 ? 63  PHE L N   1 
ATOM   1414 C CA  . PHE B 2 62  ? 188.372 204.582 217.851 1.00 47.39 ? 63  PHE L CA  1 
ATOM   1415 C C   . PHE B 2 62  ? 188.558 204.432 216.346 1.00 47.39 ? 63  PHE L C   1 
ATOM   1416 O O   . PHE B 2 62  ? 187.619 204.102 215.617 1.00 47.39 ? 63  PHE L O   1 
ATOM   1417 C CB  . PHE B 2 62  ? 188.755 203.279 218.552 1.00 47.39 ? 63  PHE L CB  1 
ATOM   1418 C CG  . PHE B 2 62  ? 188.744 203.370 220.047 1.00 47.39 ? 63  PHE L CG  1 
ATOM   1419 C CD1 . PHE B 2 62  ? 189.832 203.873 220.731 1.00 47.39 ? 63  PHE L CD1 1 
ATOM   1420 C CD2 . PHE B 2 62  ? 187.643 202.957 220.768 1.00 47.39 ? 63  PHE L CD2 1 
ATOM   1421 C CE1 . PHE B 2 62  ? 189.823 203.959 222.105 1.00 47.39 ? 63  PHE L CE1 1 
ATOM   1422 C CE2 . PHE B 2 62  ? 187.630 203.041 222.142 1.00 47.39 ? 63  PHE L CE2 1 
ATOM   1423 C CZ  . PHE B 2 62  ? 188.722 203.541 222.810 1.00 47.39 ? 63  PHE L CZ  1 
ATOM   1424 N N   . SER B 2 63  ? 189.783 204.674 215.886 1.00 48.58 ? 64  SER L N   1 
ATOM   1425 C CA  . SER B 2 63  ? 190.110 204.535 214.474 1.00 48.58 ? 64  SER L CA  1 
ATOM   1426 C C   . SER B 2 63  ? 191.622 204.518 214.313 1.00 48.58 ? 64  SER L C   1 
ATOM   1427 O O   . SER B 2 63  ? 192.330 205.235 215.021 1.00 48.58 ? 64  SER L O   1 
ATOM   1428 C CB  . SER B 2 63  ? 189.503 205.672 213.645 1.00 48.58 ? 64  SER L CB  1 
ATOM   1429 O OG  . SER B 2 63  ? 188.159 205.386 213.301 1.00 48.58 ? 64  SER L OG  1 
ATOM   1430 N N   . GLY B 2 64  ? 192.102 203.707 213.386 1.00 47.31 ? 65  GLY L N   1 
ATOM   1431 C CA  . GLY B 2 64  ? 193.530 203.591 213.138 1.00 47.31 ? 65  GLY L CA  1 
ATOM   1432 C C   . GLY B 2 64  ? 193.847 203.713 211.665 1.00 47.31 ? 65  GLY L C   1 
ATOM   1433 O O   . GLY B 2 64  ? 193.098 203.233 210.816 1.00 47.31 ? 65  GLY L O   1 
ATOM   1434 N N   . SER B 2 65  ? 194.973 204.358 211.371 1.00 47.54 ? 66  SER L N   1 
ATOM   1435 C CA  . SER B 2 65  ? 195.404 204.594 210.002 1.00 47.54 ? 66  SER L CA  1 
ATOM   1436 C C   . SER B 2 65  ? 196.857 204.178 209.838 1.00 47.54 ? 66  SER L C   1 
ATOM   1437 O O   . SER B 2 65  ? 197.664 204.338 210.756 1.00 47.54 ? 66  SER L O   1 
ATOM   1438 C CB  . SER B 2 65  ? 195.243 206.066 209.613 1.00 47.54 ? 66  SER L CB  1 
ATOM   1439 O OG  . SER B 2 65  ? 196.281 206.852 210.170 1.00 47.54 ? 66  SER L OG  1 
ATOM   1440 N N   . ARG B 2 66  ? 197.183 203.650 208.661 1.00 49.70 ? 67  ARG L N   1 
ATOM   1441 C CA  . ARG B 2 66  ? 198.534 203.223 208.326 1.00 49.70 ? 67  ARG L CA  1 
ATOM   1442 C C   . ARG B 2 66  ? 199.031 203.988 207.109 1.00 49.70 ? 67  ARG L C   1 
ATOM   1443 O O   . ARG B 2 66  ? 198.290 204.178 206.140 1.00 49.70 ? 67  ARG L O   1 
ATOM   1444 C CB  . ARG B 2 66  ? 198.591 201.722 208.038 1.00 49.70 ? 67  ARG L CB  1 
ATOM   1445 C CG  . ARG B 2 66  ? 199.930 201.256 207.494 1.00 49.70 ? 67  ARG L CG  1 
ATOM   1446 C CD  . ARG B 2 66  ? 199.805 199.967 206.710 1.00 49.70 ? 67  ARG L CD  1 
ATOM   1447 N NE  . ARG B 2 66  ? 201.045 199.643 206.018 1.00 49.70 ? 67  ARG L NE  1 
ATOM   1448 C CZ  . ARG B 2 66  ? 201.111 198.992 204.866 1.00 49.70 ? 67  ARG L CZ  1 
ATOM   1449 N NH1 . ARG B 2 66  ? 200.021 198.580 204.242 1.00 49.70 ? 67  ARG L NH1 1 
ATOM   1450 N NH2 . ARG B 2 66  ? 202.301 198.747 204.327 1.00 49.70 ? 67  ARG L NH2 1 
ATOM   1451 N N   . SER B 2 67  ? 200.289 204.427 207.162 1.00 51.61 ? 68  SER L N   1 
ATOM   1452 C CA  . SER B 2 67  ? 200.955 205.053 206.017 1.00 51.61 ? 68  SER L CA  1 
ATOM   1453 C C   . SER B 2 67  ? 202.412 204.595 206.031 1.00 51.61 ? 68  SER L C   1 
ATOM   1454 O O   . SER B 2 67  ? 203.262 205.212 206.675 1.00 51.61 ? 68  SER L O   1 
ATOM   1455 C CB  . SER B 2 67  ? 200.836 206.569 206.070 1.00 51.61 ? 68  SER L CB  1 
ATOM   1456 O OG  . SER B 2 67  ? 201.440 207.085 207.243 1.00 51.61 ? 68  SER L OG  1 
ATOM   1457 N N   . GLY B 2 68  ? 202.694 203.513 205.313 1.00 51.18 ? 69  GLY L N   1 
ATOM   1458 C CA  . GLY B 2 68  ? 204.034 202.966 205.285 1.00 51.18 ? 69  GLY L CA  1 
ATOM   1459 C C   . GLY B 2 68  ? 204.367 202.206 206.549 1.00 51.18 ? 69  GLY L C   1 
ATOM   1460 O O   . GLY B 2 68  ? 203.810 201.135 206.801 1.00 51.18 ? 69  GLY L O   1 
ATOM   1461 N N   . THR B 2 69  ? 205.275 202.746 207.351 1.00 50.17 ? 70  THR L N   1 
ATOM   1462 C CA  . THR B 2 69  ? 205.607 202.192 208.655 1.00 50.17 ? 70  THR L CA  1 
ATOM   1463 C C   . THR B 2 69  ? 205.224 203.165 209.764 1.00 50.17 ? 70  THR L C   1 
ATOM   1464 O O   . THR B 2 69  ? 205.919 203.292 210.772 1.00 50.17 ? 70  THR L O   1 
ATOM   1465 C CB  . THR B 2 69  ? 207.087 201.830 208.742 1.00 50.17 ? 70  THR L CB  1 
ATOM   1466 O OG1 . THR B 2 69  ? 207.831 202.967 209.195 1.00 50.17 ? 70  THR L OG1 1 
ATOM   1467 C CG2 . THR B 2 69  ? 207.609 201.403 207.386 1.00 50.17 ? 70  THR L CG2 1 
ATOM   1468 N N   . ASP B 2 70  ? 204.107 203.866 209.584 1.00 51.63 ? 71  ASP L N   1 
ATOM   1469 C CA  . ASP B 2 70  ? 203.609 204.825 210.562 1.00 51.63 ? 71  ASP L CA  1 
ATOM   1470 C C   . ASP B 2 70  ? 202.147 204.520 210.843 1.00 51.63 ? 71  ASP L C   1 
ATOM   1471 O O   . ASP B 2 70  ? 201.312 204.594 209.936 1.00 51.63 ? 71  ASP L O   1 
ATOM   1472 C CB  . ASP B 2 70  ? 203.768 206.262 210.059 1.00 51.63 ? 71  ASP L CB  1 
ATOM   1473 C CG  . ASP B 2 70  ? 205.217 206.644 209.833 1.00 51.63 ? 71  ASP L CG  1 
ATOM   1474 O OD1 . ASP B 2 70  ? 205.927 206.900 210.827 1.00 51.63 ? 71  ASP L OD1 1 
ATOM   1475 O OD2 . ASP B 2 70  ? 205.646 206.687 208.660 1.00 51.63 ? 71  ASP L OD2 1 
ATOM   1476 N N   . PHE B 2 71  ? 201.838 204.186 212.093 1.00 48.19 ? 72  PHE L N   1 
ATOM   1477 C CA  . PHE B 2 71  ? 200.493 203.804 212.503 1.00 48.19 ? 72  PHE L CA  1 
ATOM   1478 C C   . PHE B 2 71  ? 200.012 204.746 213.595 1.00 48.19 ? 72  PHE L C   1 
ATOM   1479 O O   . PHE B 2 71  ? 200.717 204.966 214.584 1.00 48.19 ? 72  PHE L O   1 
ATOM   1480 C CB  . PHE B 2 71  ? 200.448 202.352 212.990 1.00 48.19 ? 72  PHE L CB  1 
ATOM   1481 C CG  . PHE B 2 71  ? 200.947 201.353 211.982 1.00 48.19 ? 72  PHE L CG  1 
ATOM   1482 C CD1 . PHE B 2 71  ? 200.067 200.491 211.361 1.00 48.19 ? 72  PHE L CD1 1 
ATOM   1483 C CD2 . PHE B 2 71  ? 202.294 201.249 211.686 1.00 48.19 ? 72  PHE L CD2 1 
ATOM   1484 C CE1 . PHE B 2 71  ? 200.513 199.574 210.437 1.00 48.19 ? 72  PHE L CE1 1 
ATOM   1485 C CE2 . PHE B 2 71  ? 202.746 200.331 210.768 1.00 48.19 ? 72  PHE L CE2 1 
ATOM   1486 C CZ  . PHE B 2 71  ? 201.856 199.492 210.140 1.00 48.19 ? 72  PHE L CZ  1 
ATOM   1487 N N   . THR B 2 72  ? 198.813 205.295 213.416 1.00 48.62 ? 73  THR L N   1 
ATOM   1488 C CA  . THR B 2 72  ? 198.260 206.286 214.327 1.00 48.62 ? 73  THR L CA  1 
ATOM   1489 C C   . THR B 2 72  ? 196.885 205.844 214.797 1.00 48.62 ? 73  THR L C   1 
ATOM   1490 O O   . THR B 2 72  ? 196.048 205.440 213.985 1.00 48.62 ? 73  THR L O   1 
ATOM   1491 C CB  . THR B 2 72  ? 198.160 207.657 213.660 1.00 48.62 ? 73  THR L CB  1 
ATOM   1492 O OG1 . THR B 2 72  ? 197.684 207.500 212.319 1.00 48.62 ? 73  THR L OG1 1 
ATOM   1493 C CG2 . THR B 2 72  ? 199.520 208.332 213.632 1.00 48.62 ? 73  THR L CG2 1 
ATOM   1494 N N   . LEU B 2 73  ? 196.655 205.927 216.104 1.00 48.00 ? 74  LEU L N   1 
ATOM   1495 C CA  . LEU B 2 73  ? 195.380 205.584 216.715 1.00 48.00 ? 74  LEU L CA  1 
ATOM   1496 C C   . LEU B 2 73  ? 194.781 206.838 217.326 1.00 48.00 ? 74  LEU L C   1 
ATOM   1497 O O   . LEU B 2 73  ? 195.443 207.527 218.109 1.00 48.00 ? 74  LEU L O   1 
ATOM   1498 C CB  . LEU B 2 73  ? 195.553 204.502 217.780 1.00 48.00 ? 74  LEU L CB  1 
ATOM   1499 C CG  . LEU B 2 73  ? 194.464 204.371 218.839 1.00 48.00 ? 74  LEU L CG  1 
ATOM   1500 C CD1 . LEU B 2 73  ? 193.162 203.910 218.217 1.00 48.00 ? 74  LEU L CD1 1 
ATOM   1501 C CD2 . LEU B 2 73  ? 194.905 203.403 219.915 1.00 48.00 ? 74  LEU L CD2 1 
ATOM   1502 N N   . THR B 2 74  ? 193.536 207.133 216.971 1.00 50.71 ? 75  THR L N   1 
ATOM   1503 C CA  . THR B 2 74  ? 192.864 208.346 217.405 1.00 50.71 ? 75  THR L CA  1 
ATOM   1504 C C   . THR B 2 74  ? 191.576 208.000 218.132 1.00 50.71 ? 75  THR L C   1 
ATOM   1505 O O   . THR B 2 74  ? 190.860 207.074 217.741 1.00 50.71 ? 75  THR L O   1 
ATOM   1506 C CB  . THR B 2 74  ? 192.547 209.261 216.220 1.00 50.71 ? 75  THR L CB  1 
ATOM   1507 O OG1 . THR B 2 74  ? 191.427 208.735 215.499 1.00 50.71 ? 75  THR L OG1 1 
ATOM   1508 C CG2 . THR B 2 74  ? 193.741 209.361 215.284 1.00 50.71 ? 75  THR L CG2 1 
ATOM   1509 N N   . ILE B 2 75  ? 191.292 208.743 219.195 1.00 51.23 ? 76  ILE L N   1 
ATOM   1510 C CA  . ILE B 2 75  ? 189.998 208.716 219.861 1.00 51.23 ? 76  ILE L CA  1 
ATOM   1511 C C   . ILE B 2 75  ? 189.390 210.103 219.721 1.00 51.23 ? 76  ILE L C   1 
ATOM   1512 O O   . ILE B 2 75  ? 189.894 211.072 220.302 1.00 51.23 ? 76  ILE L O   1 
ATOM   1513 C CB  . ILE B 2 75  ? 190.108 208.286 221.329 1.00 51.23 ? 76  ILE L CB  1 
ATOM   1514 C CG1 . ILE B 2 75  ? 191.091 207.120 221.465 1.00 51.23 ? 76  ILE L CG1 1 
ATOM   1515 C CG2 . ILE B 2 75  ? 188.743 207.909 221.875 1.00 51.23 ? 76  ILE L CG2 1 
ATOM   1516 C CD1 . ILE B 2 75  ? 192.404 207.453 222.104 1.00 51.23 ? 76  ILE L CD1 1 
ATOM   1517 N N   . SER B 2 76  ? 188.308 210.195 218.945 1.00 53.32 ? 77  SER L N   1 
ATOM   1518 C CA  . SER B 2 76  ? 187.792 211.495 218.527 1.00 53.32 ? 77  SER L CA  1 
ATOM   1519 C C   . SER B 2 76  ? 187.319 212.320 219.713 1.00 53.32 ? 77  SER L C   1 
ATOM   1520 O O   . SER B 2 76  ? 187.599 213.522 219.794 1.00 53.32 ? 77  SER L O   1 
ATOM   1521 C CB  . SER B 2 76  ? 186.656 211.306 217.523 1.00 53.32 ? 77  SER L CB  1 
ATOM   1522 O OG  . SER B 2 76  ? 185.635 210.486 218.060 1.00 53.32 ? 77  SER L OG  1 
ATOM   1523 N N   . SER B 2 77  ? 186.596 211.700 220.639 1.00 52.07 ? 78  SER L N   1 
ATOM   1524 C CA  . SER B 2 77  ? 186.086 212.393 221.822 1.00 52.07 ? 78  SER L CA  1 
ATOM   1525 C C   . SER B 2 77  ? 186.228 211.422 222.987 1.00 52.07 ? 78  SER L C   1 
ATOM   1526 O O   . SER B 2 77  ? 185.335 210.612 223.243 1.00 52.07 ? 78  SER L O   1 
ATOM   1527 C CB  . SER B 2 77  ? 184.645 212.840 221.626 1.00 52.07 ? 78  SER L CB  1 
ATOM   1528 O OG  . SER B 2 77  ? 184.508 213.606 220.443 1.00 52.07 ? 78  SER L OG  1 
ATOM   1529 N N   . LEU B 2 78  ? 187.355 211.507 223.687 1.00 50.66 ? 79  LEU L N   1 
ATOM   1530 C CA  . LEU B 2 78  ? 187.623 210.562 224.756 1.00 50.66 ? 79  LEU L CA  1 
ATOM   1531 C C   . LEU B 2 78  ? 186.744 210.858 225.962 1.00 50.66 ? 79  LEU L C   1 
ATOM   1532 O O   . LEU B 2 78  ? 186.342 211.998 226.207 1.00 50.66 ? 79  LEU L O   1 
ATOM   1533 C CB  . LEU B 2 78  ? 189.099 210.593 225.145 1.00 50.66 ? 79  LEU L CB  1 
ATOM   1534 C CG  . LEU B 2 78  ? 189.671 211.858 225.769 1.00 50.66 ? 79  LEU L CG  1 
ATOM   1535 C CD1 . LEU B 2 78  ? 189.796 211.673 227.267 1.00 50.66 ? 79  LEU L CD1 1 
ATOM   1536 C CD2 . LEU B 2 78  ? 191.016 212.190 225.156 1.00 50.66 ? 79  LEU L CD2 1 
ATOM   1537 N N   . GLN B 2 79  ? 186.445 209.812 226.714 1.00 52.44 ? 80  GLN L N   1 
ATOM   1538 C CA  . GLN B 2 79  ? 185.523 209.843 227.837 1.00 52.44 ? 80  GLN L CA  1 
ATOM   1539 C C   . GLN B 2 79  ? 186.236 209.329 229.074 1.00 52.44 ? 80  GLN L C   1 
ATOM   1540 O O   . GLN B 2 79  ? 187.349 208.799 228.985 1.00 52.44 ? 80  GLN L O   1 
ATOM   1541 C CB  . GLN B 2 79  ? 184.288 208.987 227.518 1.00 52.44 ? 80  GLN L CB  1 
ATOM   1542 C CG  . GLN B 2 79  ? 183.425 209.569 226.422 1.00 52.44 ? 80  GLN L CG  1 
ATOM   1543 C CD  . GLN B 2 79  ? 182.161 208.770 226.196 1.00 52.44 ? 80  GLN L CD  1 
ATOM   1544 O OE1 . GLN B 2 79  ? 181.862 207.838 226.942 1.00 52.44 ? 80  GLN L OE1 1 
ATOM   1545 N NE2 . GLN B 2 79  ? 181.410 209.130 225.162 1.00 52.44 ? 80  GLN L NE2 1 
ATOM   1546 N N   . PRO B 2 80  ? 185.632 209.483 230.258 1.00 51.20 ? 81  PRO L N   1 
ATOM   1547 C CA  . PRO B 2 80  ? 186.308 209.033 231.486 1.00 51.20 ? 81  PRO L CA  1 
ATOM   1548 C C   . PRO B 2 80  ? 186.703 207.567 231.493 1.00 51.20 ? 81  PRO L C   1 
ATOM   1549 O O   . PRO B 2 80  ? 187.637 207.205 232.218 1.00 51.20 ? 81  PRO L O   1 
ATOM   1550 C CB  . PRO B 2 80  ? 185.280 209.336 232.589 1.00 51.20 ? 81  PRO L CB  1 
ATOM   1551 C CG  . PRO B 2 80  ? 184.040 209.809 231.887 1.00 51.20 ? 81  PRO L CG  1 
ATOM   1552 C CD  . PRO B 2 80  ? 184.476 210.335 230.571 1.00 51.20 ? 81  PRO L CD  1 
ATOM   1553 N N   . GLU B 2 81  ? 186.039 206.710 230.726 1.00 51.82 ? 82  GLU L N   1 
ATOM   1554 C CA  . GLU B 2 81  ? 186.380 205.296 230.693 1.00 51.82 ? 82  GLU L CA  1 
ATOM   1555 C C   . GLU B 2 81  ? 187.470 204.970 229.679 1.00 51.82 ? 82  GLU L C   1 
ATOM   1556 O O   . GLU B 2 81  ? 187.775 203.792 229.477 1.00 51.82 ? 82  GLU L O   1 
ATOM   1557 C CB  . GLU B 2 81  ? 185.139 204.450 230.400 1.00 51.82 ? 82  GLU L CB  1 
ATOM   1558 C CG  . GLU B 2 81  ? 184.020 204.579 231.420 1.00 51.82 ? 82  GLU L CG  1 
ATOM   1559 C CD  . GLU B 2 81  ? 183.125 205.780 231.175 1.00 51.82 ? 82  GLU L CD  1 
ATOM   1560 O OE1 . GLU B 2 81  ? 183.649 206.863 230.843 1.00 51.82 ? 82  GLU L OE1 1 
ATOM   1561 O OE2 . GLU B 2 81  ? 181.892 205.639 231.315 1.00 51.82 ? 82  GLU L OE2 1 
ATOM   1562 N N   . ASP B 2 82  ? 188.060 205.978 229.040 1.00 49.85 ? 83  ASP L N   1 
ATOM   1563 C CA  . ASP B 2 82  ? 189.081 205.766 228.024 1.00 49.85 ? 83  ASP L CA  1 
ATOM   1564 C C   . ASP B 2 82  ? 190.496 205.980 228.545 1.00 49.85 ? 83  ASP L C   1 
ATOM   1565 O O   . ASP B 2 82  ? 191.439 205.999 227.748 1.00 49.85 ? 83  ASP L O   1 
ATOM   1566 C CB  . ASP B 2 82  ? 188.828 206.682 226.827 1.00 49.85 ? 83  ASP L CB  1 
ATOM   1567 C CG  . ASP B 2 82  ? 187.941 206.042 225.787 1.00 49.85 ? 83  ASP L CG  1 
ATOM   1568 O OD1 . ASP B 2 82  ? 186.895 205.478 226.163 1.00 49.85 ? 83  ASP L OD1 1 
ATOM   1569 O OD2 . ASP B 2 82  ? 188.287 206.102 224.591 1.00 49.85 ? 83  ASP L OD2 1 
ATOM   1570 N N   . PHE B 2 83  ? 190.671 206.135 229.854 1.00 47.62 ? 84  PHE L N   1 
ATOM   1571 C CA  . PHE B 2 83  ? 191.975 206.440 230.434 1.00 47.62 ? 84  PHE L CA  1 
ATOM   1572 C C   . PHE B 2 83  ? 192.667 205.144 230.835 1.00 47.62 ? 84  PHE L C   1 
ATOM   1573 O O   . PHE B 2 83  ? 192.246 204.472 231.781 1.00 47.62 ? 84  PHE L O   1 
ATOM   1574 C CB  . PHE B 2 83  ? 191.822 207.372 231.629 1.00 47.62 ? 84  PHE L CB  1 
ATOM   1575 C CG  . PHE B 2 83  ? 191.461 208.771 231.254 1.00 47.62 ? 84  PHE L CG  1 
ATOM   1576 C CD1 . PHE B 2 83  ? 190.144 209.127 231.057 1.00 47.62 ? 84  PHE L CD1 1 
ATOM   1577 C CD2 . PHE B 2 83  ? 192.440 209.730 231.091 1.00 47.62 ? 84  PHE L CD2 1 
ATOM   1578 C CE1 . PHE B 2 83  ? 189.808 210.414 230.712 1.00 47.62 ? 84  PHE L CE1 1 
ATOM   1579 C CE2 . PHE B 2 83  ? 192.108 211.021 230.743 1.00 47.62 ? 84  PHE L CE2 1 
ATOM   1580 C CZ  . PHE B 2 83  ? 190.790 211.362 230.554 1.00 47.62 ? 84  PHE L CZ  1 
ATOM   1581 N N   . ALA B 2 84  ? 193.731 204.803 230.123 1.00 45.33 ? 85  ALA L N   1 
ATOM   1582 C CA  . ALA B 2 84  ? 194.501 203.587 230.359 1.00 45.33 ? 85  ALA L CA  1 
ATOM   1583 C C   . ALA B 2 84  ? 195.808 203.716 229.585 1.00 45.33 ? 85  ALA L C   1 
ATOM   1584 O O   . ALA B 2 84  ? 196.134 204.788 229.063 1.00 45.33 ? 85  ALA L O   1 
ATOM   1585 C CB  . ALA B 2 84  ? 193.712 202.341 229.953 1.00 45.33 ? 85  ALA L CB  1 
ATOM   1586 N N   . THR B 2 85  ? 196.558 202.625 229.514 1.00 44.20 ? 86  THR L N   1 
ATOM   1587 C CA  . THR B 2 85  ? 197.804 202.578 228.766 1.00 44.20 ? 86  THR L CA  1 
ATOM   1588 C C   . THR B 2 85  ? 197.594 201.768 227.496 1.00 44.20 ? 86  THR L C   1 
ATOM   1589 O O   . THR B 2 85  ? 197.074 200.649 227.549 1.00 44.20 ? 86  THR L O   1 
ATOM   1590 C CB  . THR B 2 85  ? 198.923 201.962 229.603 1.00 44.20 ? 86  THR L CB  1 
ATOM   1591 O OG1 . THR B 2 85  ? 199.227 202.829 230.702 1.00 44.20 ? 86  THR L OG1 1 
ATOM   1592 C CG2 . THR B 2 85  ? 200.166 201.778 228.764 1.00 44.20 ? 86  THR L CG2 1 
ATOM   1593 N N   . TYR B 2 86  ? 197.989 202.333 226.363 1.00 43.77 ? 87  TYR L N   1 
ATOM   1594 C CA  . TYR B 2 86  ? 197.817 201.682 225.076 1.00 43.77 ? 87  TYR L CA  1 
ATOM   1595 C C   . TYR B 2 86  ? 199.154 201.160 224.567 1.00 43.77 ? 87  TYR L C   1 
ATOM   1596 O O   . TYR B 2 86  ? 200.209 201.740 224.833 1.00 43.77 ? 87  TYR L O   1 
ATOM   1597 C CB  . TYR B 2 86  ? 197.204 202.643 224.062 1.00 43.77 ? 87  TYR L CB  1 
ATOM   1598 C CG  . TYR B 2 86  ? 195.897 203.232 224.523 1.00 43.77 ? 87  TYR L CG  1 
ATOM   1599 C CD1 . TYR B 2 86  ? 195.871 204.353 225.332 1.00 43.77 ? 87  TYR L CD1 1 
ATOM   1600 C CD2 . TYR B 2 86  ? 194.689 202.669 224.151 1.00 43.77 ? 87  TYR L CD2 1 
ATOM   1601 C CE1 . TYR B 2 86  ? 194.688 204.895 225.756 1.00 43.77 ? 87  TYR L CE1 1 
ATOM   1602 C CE2 . TYR B 2 86  ? 193.497 203.208 224.575 1.00 43.77 ? 87  TYR L CE2 1 
ATOM   1603 C CZ  . TYR B 2 86  ? 193.506 204.323 225.375 1.00 43.77 ? 87  TYR L CZ  1 
ATOM   1604 O OH  . TYR B 2 86  ? 192.324 204.869 225.805 1.00 43.77 ? 87  TYR L OH  1 
ATOM   1605 N N   . TYR B 2 87  ? 199.098 200.055 223.829 1.00 41.95 ? 88  TYR L N   1 
ATOM   1606 C CA  . TYR B 2 87  ? 200.288 199.343 223.393 1.00 41.95 ? 88  TYR L CA  1 
ATOM   1607 C C   . TYR B 2 87  ? 200.222 199.067 221.899 1.00 41.95 ? 88  TYR L C   1 
ATOM   1608 O O   . TYR B 2 87  ? 199.149 198.859 221.334 1.00 41.95 ? 88  TYR L O   1 
ATOM   1609 C CB  . TYR B 2 87  ? 200.448 198.028 224.148 1.00 41.95 ? 88  TYR L CB  1 
ATOM   1610 C CG  . TYR B 2 87  ? 200.751 198.193 225.616 1.00 41.95 ? 88  TYR L CG  1 
ATOM   1611 C CD1 . TYR B 2 87  ? 201.809 198.978 226.040 1.00 41.95 ? 88  TYR L CD1 1 
ATOM   1612 C CD2 . TYR B 2 87  ? 199.980 197.564 226.578 1.00 41.95 ? 88  TYR L CD2 1 
ATOM   1613 C CE1 . TYR B 2 87  ? 202.092 199.127 227.377 1.00 41.95 ? 88  TYR L CE1 1 
ATOM   1614 C CE2 . TYR B 2 87  ? 200.256 197.711 227.920 1.00 41.95 ? 88  TYR L CE2 1 
ATOM   1615 C CZ  . TYR B 2 87  ? 201.313 198.498 228.312 1.00 41.95 ? 88  TYR L CZ  1 
ATOM   1616 O OH  . TYR B 2 87  ? 201.599 198.654 229.647 1.00 41.95 ? 88  TYR L OH  1 
ATOM   1617 N N   . CYS B 2 88  ? 201.385 199.065 221.270 1.00 46.87 ? 89  CYS L N   1 
ATOM   1618 C CA  . CYS B 2 88  ? 201.549 198.687 219.877 1.00 46.87 ? 89  CYS L CA  1 
ATOM   1619 C C   . CYS B 2 88  ? 202.013 197.239 219.802 1.00 46.87 ? 89  CYS L C   1 
ATOM   1620 O O   . CYS B 2 88  ? 202.646 196.722 220.722 1.00 46.87 ? 89  CYS L O   1 
ATOM   1621 C CB  . CYS B 2 88  ? 202.565 199.606 219.197 1.00 46.87 ? 89  CYS L CB  1 
ATOM   1622 S SG  . CYS B 2 88  ? 202.294 199.958 217.451 1.00 46.87 ? 89  CYS L SG  1 
ATOM   1623 N N   . GLN B 2 89  ? 201.691 196.579 218.692 1.00 44.69 ? 90  GLN L N   1 
ATOM   1624 C CA  . GLN B 2 89  ? 202.110 195.196 218.507 1.00 44.69 ? 90  GLN L CA  1 
ATOM   1625 C C   . GLN B 2 89  ? 202.110 194.845 217.033 1.00 44.69 ? 90  GLN L C   1 
ATOM   1626 O O   . GLN B 2 89  ? 201.181 195.209 216.311 1.00 44.69 ? 90  GLN L O   1 
ATOM   1627 C CB  . GLN B 2 89  ? 201.198 194.225 219.255 1.00 44.69 ? 90  GLN L CB  1 
ATOM   1628 C CG  . GLN B 2 89  ? 201.657 192.787 219.129 1.00 44.69 ? 90  GLN L CG  1 
ATOM   1629 C CD  . GLN B 2 89  ? 200.510 191.812 219.095 1.00 44.69 ? 90  GLN L CD  1 
ATOM   1630 O OE1 . GLN B 2 89  ? 199.625 191.851 219.943 1.00 44.69 ? 90  GLN L OE1 1 
ATOM   1631 N NE2 . GLN B 2 89  ? 200.512 190.932 218.105 1.00 44.69 ? 90  GLN L NE2 1 
ATOM   1632 N N   . GLN B 2 90  ? 203.128 194.111 216.602 1.00 45.25 ? 91  GLN L N   1 
ATOM   1633 C CA  . GLN B 2 90  ? 203.183 193.554 215.261 1.00 45.25 ? 91  GLN L CA  1 
ATOM   1634 C C   . GLN B 2 90  ? 203.074 192.037 215.323 1.00 45.25 ? 91  GLN L C   1 
ATOM   1635 O O   . GLN B 2 90  ? 203.617 191.403 216.231 1.00 45.25 ? 91  GLN L O   1 
ATOM   1636 C CB  . GLN B 2 90  ? 204.473 193.949 214.563 1.00 45.25 ? 91  GLN L CB  1 
ATOM   1637 C CG  . GLN B 2 90  ? 205.686 193.518 215.311 1.00 45.25 ? 91  GLN L CG  1 
ATOM   1638 C CD  . GLN B 2 90  ? 206.773 193.082 214.386 1.00 45.25 ? 91  GLN L CD  1 
ATOM   1639 O OE1 . GLN B 2 90  ? 207.742 193.797 214.190 1.00 45.25 ? 91  GLN L OE1 1 
ATOM   1640 N NE2 . GLN B 2 90  ? 206.624 191.898 213.807 1.00 45.25 ? 91  GLN L NE2 1 
ATOM   1641 N N   . TYR B 2 91  ? 202.365 191.459 214.359 1.00 42.59 ? 92  TYR L N   1 
ATOM   1642 C CA  . TYR B 2 91  ? 202.099 190.026 214.349 1.00 42.59 ? 92  TYR L CA  1 
ATOM   1643 C C   . TYR B 2 91  ? 202.318 189.446 212.954 1.00 42.59 ? 92  TYR L C   1 
ATOM   1644 O O   . TYR B 2 91  ? 201.478 188.727 212.413 1.00 42.59 ? 92  TYR L O   1 
ATOM   1645 C CB  . TYR B 2 91  ? 200.698 189.728 214.880 1.00 42.59 ? 92  TYR L CB  1 
ATOM   1646 C CG  . TYR B 2 91  ? 199.561 190.526 214.281 1.00 42.59 ? 92  TYR L CG  1 
ATOM   1647 C CD1 . TYR B 2 91  ? 199.232 191.772 214.777 1.00 42.59 ? 92  TYR L CD1 1 
ATOM   1648 C CD2 . TYR B 2 91  ? 198.786 190.005 213.261 1.00 42.59 ? 92  TYR L CD2 1 
ATOM   1649 C CE1 . TYR B 2 91  ? 198.187 192.491 214.251 1.00 42.59 ? 92  TYR L CE1 1 
ATOM   1650 C CE2 . TYR B 2 91  ? 197.739 190.717 212.731 1.00 42.59 ? 92  TYR L CE2 1 
ATOM   1651 C CZ  . TYR B 2 91  ? 197.445 191.957 213.227 1.00 42.59 ? 92  TYR L CZ  1 
ATOM   1652 O OH  . TYR B 2 91  ? 196.399 192.670 212.697 1.00 42.59 ? 92  TYR L OH  1 
ATOM   1653 N N   . LEU B 2 92  ? 203.464 189.769 212.352 1.00 44.80 ? 93  LEU L N   1 
ATOM   1654 C CA  . LEU B 2 92  ? 203.780 189.250 211.024 1.00 44.80 ? 93  LEU L CA  1 
ATOM   1655 C C   . LEU B 2 92  ? 203.899 187.731 211.030 1.00 44.80 ? 93  LEU L C   1 
ATOM   1656 O O   . LEU B 2 92  ? 203.368 187.056 210.141 1.00 44.80 ? 93  LEU L O   1 
ATOM   1657 C CB  . LEU B 2 92  ? 205.070 189.880 210.511 1.00 44.80 ? 93  LEU L CB  1 
ATOM   1658 C CG  . LEU B 2 92  ? 205.444 189.553 209.070 1.00 44.80 ? 93  LEU L CG  1 
ATOM   1659 C CD1 . LEU B 2 92  ? 204.336 189.987 208.135 1.00 44.80 ? 93  LEU L CD1 1 
ATOM   1660 C CD2 . LEU B 2 92  ? 206.739 190.240 208.709 1.00 44.80 ? 93  LEU L CD2 1 
ATOM   1661 N N   . TYR B 2 93  ? 204.596 187.176 212.015 1.00 45.60 ? 94  TYR L N   1 
ATOM   1662 C CA  . TYR B 2 93  ? 204.688 185.737 212.190 1.00 45.60 ? 94  TYR L CA  1 
ATOM   1663 C C   . TYR B 2 93  ? 204.672 185.434 213.682 1.00 45.60 ? 94  TYR L C   1 
ATOM   1664 O O   . TYR B 2 93  ? 204.739 186.336 214.520 1.00 45.60 ? 94  TYR L O   1 
ATOM   1665 C CB  . TYR B 2 93  ? 205.942 185.160 211.517 1.00 45.60 ? 94  TYR L CB  1 
ATOM   1666 C CG  . TYR B 2 93  ? 205.978 183.652 211.506 1.00 45.60 ? 94  TYR L CG  1 
ATOM   1667 C CD1 . TYR B 2 93  ? 204.902 182.922 211.034 1.00 45.60 ? 94  TYR L CD1 1 
ATOM   1668 C CD2 . TYR B 2 93  ? 207.076 182.958 211.984 1.00 45.60 ? 94  TYR L CD2 1 
ATOM   1669 C CE1 . TYR B 2 93  ? 204.921 181.547 211.031 1.00 45.60 ? 94  TYR L CE1 1 
ATOM   1670 C CE2 . TYR B 2 93  ? 207.102 181.580 211.983 1.00 45.60 ? 94  TYR L CE2 1 
ATOM   1671 C CZ  . TYR B 2 93  ? 206.020 180.881 211.507 1.00 45.60 ? 94  TYR L CZ  1 
ATOM   1672 O OH  . TYR B 2 93  ? 206.036 179.509 211.503 1.00 45.60 ? 94  TYR L OH  1 
ATOM   1673 N N   . TYR B 2 94  ? 204.575 184.146 214.011 1.00 44.58 ? 95  TYR L N   1 
ATOM   1674 C CA  . TYR B 2 94  ? 204.419 183.743 215.404 1.00 44.58 ? 95  TYR L CA  1 
ATOM   1675 C C   . TYR B 2 94  ? 205.641 184.094 216.242 1.00 44.58 ? 95  TYR L C   1 
ATOM   1676 O O   . TYR B 2 94  ? 205.505 184.573 217.373 1.00 44.58 ? 95  TYR L O   1 
ATOM   1677 C CB  . TYR B 2 94  ? 204.146 182.247 215.482 1.00 44.58 ? 95  TYR L CB  1 
ATOM   1678 C CG  . TYR B 2 94  ? 202.761 181.847 215.054 1.00 44.58 ? 95  TYR L CG  1 
ATOM   1679 C CD1 . TYR B 2 94  ? 201.645 182.415 215.637 1.00 44.58 ? 95  TYR L CD1 1 
ATOM   1680 C CD2 . TYR B 2 94  ? 202.571 180.891 214.075 1.00 44.58 ? 95  TYR L CD2 1 
ATOM   1681 C CE1 . TYR B 2 94  ? 200.375 182.044 215.252 1.00 44.58 ? 95  TYR L CE1 1 
ATOM   1682 C CE2 . TYR B 2 94  ? 201.310 180.516 213.684 1.00 44.58 ? 95  TYR L CE2 1 
ATOM   1683 C CZ  . TYR B 2 94  ? 200.216 181.095 214.273 1.00 44.58 ? 95  TYR L CZ  1 
ATOM   1684 O OH  . TYR B 2 94  ? 198.950 180.726 213.888 1.00 44.58 ? 95  TYR L OH  1 
ATOM   1685 N N   . SER B 2 95  ? 206.836 183.859 215.718 1.00 44.86 ? 96  SER L N   1 
ATOM   1686 C CA  . SER B 2 95  ? 208.051 183.993 216.510 1.00 44.86 ? 96  SER L CA  1 
ATOM   1687 C C   . SER B 2 95  ? 208.614 185.407 216.515 1.00 44.86 ? 96  SER L C   1 
ATOM   1688 O O   . SER B 2 95  ? 209.625 185.649 217.178 1.00 44.86 ? 96  SER L O   1 
ATOM   1689 C CB  . SER B 2 95  ? 209.115 183.019 216.001 1.00 44.86 ? 96  SER L CB  1 
ATOM   1690 O OG  . SER B 2 95  ? 209.376 183.227 214.627 1.00 44.86 ? 96  SER L OG  1 
ATOM   1691 N N   . LEU B 2 96  ? 207.988 186.342 215.807 1.00 45.44 ? 97  LEU L N   1 
ATOM   1692 C CA  . LEU B 2 96  ? 208.482 187.708 215.678 1.00 45.44 ? 97  LEU L CA  1 
ATOM   1693 C C   . LEU B 2 96  ? 207.514 188.720 216.286 1.00 45.44 ? 97  LEU L C   1 
ATOM   1694 O O   . LEU B 2 96  ? 207.237 189.765 215.697 1.00 45.44 ? 97  LEU L O   1 
ATOM   1695 C CB  . LEU B 2 96  ? 208.742 188.043 214.215 1.00 45.44 ? 97  LEU L CB  1 
ATOM   1696 C CG  . LEU B 2 96  ? 209.320 186.917 213.363 1.00 45.44 ? 97  LEU L CG  1 
ATOM   1697 C CD1 . LEU B 2 96  ? 209.350 187.325 211.906 1.00 45.44 ? 97  LEU L CD1 1 
ATOM   1698 C CD2 . LEU B 2 96  ? 210.709 186.552 213.845 1.00 45.44 ? 97  LEU L CD2 1 
ATOM   1699 N N   . VAL B 2 97  ? 206.991 188.426 217.471 1.00 42.81 ? 98  VAL L N   1 
ATOM   1700 C CA  . VAL B 2 97  ? 206.007 189.287 218.118 1.00 42.81 ? 98  VAL L CA  1 
ATOM   1701 C C   . VAL B 2 97  ? 206.725 190.210 219.091 1.00 42.81 ? 98  VAL L C   1 
ATOM   1702 O O   . VAL B 2 97  ? 207.343 189.753 220.057 1.00 42.81 ? 98  VAL L O   1 
ATOM   1703 C CB  . VAL B 2 97  ? 204.933 188.460 218.836 1.00 42.81 ? 98  VAL L CB  1 
ATOM   1704 C CG1 . VAL B 2 97  ? 204.160 189.331 219.805 1.00 42.81 ? 98  VAL L CG1 1 
ATOM   1705 C CG2 . VAL B 2 97  ? 203.999 187.827 217.833 1.00 42.81 ? 98  VAL L CG2 1 
ATOM   1706 N N   . THR B 2 98  ? 206.648 191.512 218.834 1.00 44.89 ? 99  THR L N   1 
ATOM   1707 C CA  . THR B 2 98  ? 207.216 192.527 219.706 1.00 44.89 ? 99  THR L CA  1 
ATOM   1708 C C   . THR B 2 98  ? 206.154 193.569 220.014 1.00 44.89 ? 99  THR L C   1 
ATOM   1709 O O   . THR B 2 98  ? 205.275 193.843 219.194 1.00 44.89 ? 99  THR L O   1 
ATOM   1710 C CB  . THR B 2 98  ? 208.428 193.214 219.074 1.00 44.89 ? 99  THR L CB  1 
ATOM   1711 O OG1 . THR B 2 98  ? 207.981 194.156 218.093 1.00 44.89 ? 99  THR L OG1 1 
ATOM   1712 C CG2 . THR B 2 98  ? 209.342 192.197 218.414 1.00 44.89 ? 99  THR L CG2 1 
ATOM   1713 N N   . PHE B 2 99  ? 206.245 194.152 221.203 1.00 43.87 ? 100 PHE L N   1 
ATOM   1714 C CA  . PHE B 2 99  ? 205.315 195.174 221.652 1.00 43.87 ? 100 PHE L CA  1 
ATOM   1715 C C   . PHE B 2 99  ? 206.068 196.467 221.919 1.00 43.87 ? 100 PHE L C   1 
ATOM   1716 O O   . PHE B 2 99  ? 207.211 196.452 222.381 1.00 43.87 ? 100 PHE L O   1 
ATOM   1717 C CB  . PHE B 2 99  ? 204.593 194.764 222.932 1.00 43.87 ? 100 PHE L CB  1 
ATOM   1718 C CG  . PHE B 2 99  ? 203.633 193.631 222.763 1.00 43.87 ? 100 PHE L CG  1 
ATOM   1719 C CD1 . PHE B 2 99  ? 204.085 192.334 222.695 1.00 43.87 ? 100 PHE L CD1 1 
ATOM   1720 C CD2 . PHE B 2 99  ? 202.277 193.863 222.705 1.00 43.87 ? 100 PHE L CD2 1 
ATOM   1721 C CE1 . PHE B 2 99  ? 203.208 191.292 222.561 1.00 43.87 ? 100 PHE L CE1 1 
ATOM   1722 C CE2 . PHE B 2 99  ? 201.394 192.824 222.568 1.00 43.87 ? 100 PHE L CE2 1 
ATOM   1723 C CZ  . PHE B 2 99  ? 201.860 191.536 222.494 1.00 43.87 ? 100 PHE L CZ  1 
ATOM   1724 N N   . GLY B 2 100 ? 205.415 197.589 221.640 1.00 46.37 ? 101 GLY L N   1 
ATOM   1725 C CA  . GLY B 2 100 ? 205.978 198.879 221.961 1.00 46.37 ? 101 GLY L CA  1 
ATOM   1726 C C   . GLY B 2 100 ? 205.837 199.205 223.432 1.00 46.37 ? 101 GLY L C   1 
ATOM   1727 O O   . GLY B 2 100 ? 205.214 198.485 224.210 1.00 46.37 ? 101 GLY L O   1 
ATOM   1728 N N   . GLN B 2 101 ? 206.437 200.322 223.817 1.00 47.01 ? 102 GLN L N   1 
ATOM   1729 C CA  . GLN B 2 101 ? 206.356 200.788 225.189 1.00 47.01 ? 102 GLN L CA  1 
ATOM   1730 C C   . GLN B 2 101 ? 205.040 201.524 225.413 1.00 47.01 ? 102 GLN L C   1 
ATOM   1731 O O   . GLN B 2 101 ? 204.325 201.875 224.476 1.00 47.01 ? 102 GLN L O   1 
ATOM   1732 C CB  . GLN B 2 101 ? 207.546 201.683 225.515 1.00 47.01 ? 102 GLN L CB  1 
ATOM   1733 C CG  . GLN B 2 101 ? 208.884 200.997 225.331 1.00 47.01 ? 102 GLN L CG  1 
ATOM   1734 C CD  . GLN B 2 101 ? 209.415 200.409 226.620 1.00 47.01 ? 102 GLN L CD  1 
ATOM   1735 O OE1 . GLN B 2 101 ? 208.649 199.962 227.472 1.00 47.01 ? 102 GLN L OE1 1 
ATOM   1736 N NE2 . GLN B 2 101 ? 210.734 200.407 226.770 1.00 47.01 ? 102 GLN L NE2 1 
ATOM   1737 N N   . GLY B 2 102 ? 204.719 201.752 226.681 1.00 47.61 ? 103 GLY L N   1 
ATOM   1738 C CA  . GLY B 2 102 ? 203.402 202.250 227.020 1.00 47.61 ? 103 GLY L CA  1 
ATOM   1739 C C   . GLY B 2 102 ? 203.227 203.724 226.714 1.00 47.61 ? 103 GLY L C   1 
ATOM   1740 O O   . GLY B 2 102 ? 204.176 204.508 226.714 1.00 47.61 ? 103 GLY L O   1 
ATOM   1741 N N   . THR B 2 103 ? 201.979 204.098 226.445 1.00 47.15 ? 104 THR L N   1 
ATOM   1742 C CA  . THR B 2 103 ? 201.554 205.490 226.387 1.00 47.15 ? 104 THR L CA  1 
ATOM   1743 C C   . THR B 2 103 ? 200.448 205.689 227.413 1.00 47.15 ? 104 THR L C   1 
ATOM   1744 O O   . THR B 2 103 ? 199.477 204.927 227.442 1.00 47.15 ? 104 THR L O   1 
ATOM   1745 C CB  . THR B 2 103 ? 201.091 205.878 224.980 1.00 47.15 ? 104 THR L CB  1 
ATOM   1746 O OG1 . THR B 2 103 ? 200.677 207.249 224.969 1.00 47.15 ? 104 THR L OG1 1 
ATOM   1747 C CG2 . THR B 2 103 ? 199.956 204.989 224.498 1.00 47.15 ? 104 THR L CG2 1 
ATOM   1748 N N   . LYS B 2 104 ? 200.609 206.685 228.274 1.00 47.22 ? 105 LYS L N   1 
ATOM   1749 C CA  . LYS B 2 104 ? 199.692 206.925 229.377 1.00 47.22 ? 105 LYS L CA  1 
ATOM   1750 C C   . LYS B 2 104 ? 198.901 208.196 229.121 1.00 47.22 ? 105 LYS L C   1 
ATOM   1751 O O   . LYS B 2 104 ? 199.464 209.218 228.719 1.00 47.22 ? 105 LYS L O   1 
ATOM   1752 C CB  . LYS B 2 104 ? 200.448 207.035 230.701 1.00 47.22 ? 105 LYS L CB  1 
ATOM   1753 C CG  . LYS B 2 104 ? 199.560 207.315 231.892 1.00 47.22 ? 105 LYS L CG  1 
ATOM   1754 C CD  . LYS B 2 104 ? 200.214 206.872 233.186 1.00 47.22 ? 105 LYS L CD  1 
ATOM   1755 C CE  . LYS B 2 104 ? 199.186 206.754 234.302 1.00 47.22 ? 105 LYS L CE  1 
ATOM   1756 N NZ  . LYS B 2 104 ? 199.703 205.981 235.463 1.00 47.22 ? 105 LYS L NZ  1 
ATOM   1757 N N   . VAL B 2 105 ? 197.594 208.131 229.351 1.00 46.38 ? 106 VAL L N   1 
ATOM   1758 C CA  . VAL B 2 105 ? 196.707 209.269 229.156 1.00 46.38 ? 106 VAL L CA  1 
ATOM   1759 C C   . VAL B 2 105 ? 196.152 209.684 230.512 1.00 46.38 ? 106 VAL L C   1 
ATOM   1760 O O   . VAL B 2 105 ? 195.607 208.855 231.249 1.00 46.38 ? 106 VAL L O   1 
ATOM   1761 C CB  . VAL B 2 105 ? 195.583 208.947 228.155 1.00 46.38 ? 106 VAL L CB  1 
ATOM   1762 C CG1 . VAL B 2 105 ? 196.156 208.827 226.756 1.00 46.38 ? 106 VAL L CG1 1 
ATOM   1763 C CG2 . VAL B 2 105 ? 194.866 207.669 228.533 1.00 46.38 ? 106 VAL L CG2 1 
ATOM   1764 N N   . GLU B 2 106 ? 196.310 210.955 230.848 1.00 47.63 ? 107 GLU L N   1 
ATOM   1765 C CA  . GLU B 2 106 ? 195.882 211.493 232.127 1.00 47.63 ? 107 GLU L CA  1 
ATOM   1766 C C   . GLU B 2 106 ? 194.918 212.649 231.894 1.00 47.63 ? 107 GLU L C   1 
ATOM   1767 O O   . GLU B 2 106 ? 194.566 212.974 230.760 1.00 47.63 ? 107 GLU L O   1 
ATOM   1768 C CB  . GLU B 2 106 ? 197.084 211.940 232.958 1.00 47.63 ? 107 GLU L CB  1 
ATOM   1769 C CG  . GLU B 2 106 ? 198.252 210.986 232.916 1.00 47.63 ? 107 GLU L CG  1 
ATOM   1770 C CD  . GLU B 2 106 ? 199.443 211.507 233.685 1.00 47.63 ? 107 GLU L CD  1 
ATOM   1771 O OE1 . GLU B 2 106 ? 199.499 212.727 233.939 1.00 47.63 ? 107 GLU L OE1 1 
ATOM   1772 O OE2 . GLU B 2 106 ? 200.325 210.698 234.038 1.00 47.63 ? 107 GLU L OE2 1 
ATOM   1773 N N   . ILE B 2 107 ? 194.498 213.277 232.987 1.00 46.24 ? 108 ILE L N   1 
ATOM   1774 C CA  . ILE B 2 107 ? 193.536 214.371 232.955 1.00 46.24 ? 108 ILE L CA  1 
ATOM   1775 C C   . ILE B 2 107 ? 194.284 215.676 233.183 1.00 46.24 ? 108 ILE L C   1 
ATOM   1776 O O   . ILE B 2 107 ? 194.995 215.825 234.184 1.00 46.24 ? 108 ILE L O   1 
ATOM   1777 C CB  . ILE B 2 107 ? 192.429 214.171 234.000 1.00 46.24 ? 108 ILE L CB  1 
ATOM   1778 C CG1 . ILE B 2 107 ? 191.658 212.889 233.699 1.00 46.24 ? 108 ILE L CG1 1 
ATOM   1779 C CG2 . ILE B 2 107 ? 191.494 215.368 234.021 1.00 46.24 ? 108 ILE L CG2 1 
ATOM   1780 C CD1 . ILE B 2 107 ? 190.756 212.447 234.819 1.00 46.24 ? 108 ILE L CD1 1 
ATOM   1781 N N   . LYS B 2 108 ? 194.119 216.617 232.258 1.00 47.66 ? 109 LYS L N   1 
ATOM   1782 C CA  . LYS B 2 108 ? 194.875 217.867 232.264 1.00 47.66 ? 109 LYS L CA  1 
ATOM   1783 C C   . LYS B 2 108 ? 194.328 218.882 233.264 1.00 47.66 ? 109 LYS L C   1 
ATOM   1784 O O   . LYS B 2 108 ? 193.119 219.000 233.449 1.00 47.66 ? 109 LYS L O   1 
ATOM   1785 C CB  . LYS B 2 108 ? 194.884 218.472 230.861 1.00 47.66 ? 109 LYS L CB  1 
ATOM   1786 C CG  . LYS B 2 108 ? 195.667 219.760 230.749 1.00 47.66 ? 109 LYS L CG  1 
ATOM   1787 C CD  . LYS B 2 108 ? 197.089 219.501 230.283 1.00 47.66 ? 109 LYS L CD  1 
ATOM   1788 C CE  . LYS B 2 108 ? 197.167 219.439 228.767 1.00 47.66 ? 109 LYS L CE  1 
ATOM   1789 N NZ  . LYS B 2 108 ? 196.708 220.707 228.137 1.00 47.66 ? 109 LYS L NZ  1 
ATOM   1790 N N   . THR C 3 6   ? 209.959 227.977 196.743 1.00 83.25 ? 6   THR A N   1 
ATOM   1791 C CA  . THR C 3 6   ? 209.175 228.314 195.563 1.00 83.25 ? 6   THR A CA  1 
ATOM   1792 C C   . THR C 3 6   ? 210.083 228.513 194.357 1.00 83.25 ? 6   THR A C   1 
ATOM   1793 O O   . THR C 3 6   ? 211.170 229.087 194.465 1.00 83.25 ? 6   THR A O   1 
ATOM   1794 C CB  . THR C 3 6   ? 208.353 229.577 195.813 1.00 83.25 ? 6   THR A CB  1 
ATOM   1795 O OG1 . THR C 3 6   ? 207.936 229.614 197.183 1.00 83.25 ? 6   THR A OG1 1 
ATOM   1796 C CG2 . THR C 3 6   ? 207.126 229.598 194.915 1.00 83.25 ? 6   THR A CG2 1 
ATOM   1797 N N   . ARG C 3 7   ? 209.629 228.035 193.199 1.00 78.12 ? 7   ARG A N   1 
ATOM   1798 C CA  . ARG C 3 7   ? 210.399 228.127 191.963 1.00 78.12 ? 7   ARG A CA  1 
ATOM   1799 C C   . ARG C 3 7   ? 209.473 228.537 190.830 1.00 78.12 ? 7   ARG A C   1 
ATOM   1800 O O   . ARG C 3 7   ? 208.509 227.827 190.529 1.00 78.12 ? 7   ARG A O   1 
ATOM   1801 C CB  . ARG C 3 7   ? 211.082 226.795 191.641 1.00 78.12 ? 7   ARG A CB  1 
ATOM   1802 C CG  . ARG C 3 7   ? 212.262 226.467 192.540 1.00 78.12 ? 7   ARG A CG  1 
ATOM   1803 C CD  . ARG C 3 7   ? 212.900 225.142 192.154 1.00 78.12 ? 7   ARG A CD  1 
ATOM   1804 N NE  . ARG C 3 7   ? 213.204 225.073 190.729 1.00 78.12 ? 7   ARG A NE  1 
ATOM   1805 C CZ  . ARG C 3 7   ? 214.246 225.658 190.155 1.00 78.12 ? 7   ARG A CZ  1 
ATOM   1806 N NH1 . ARG C 3 7   ? 215.115 226.367 190.857 1.00 78.12 ? 7   ARG A NH1 1 
ATOM   1807 N NH2 . ARG C 3 7   ? 214.422 225.528 188.843 1.00 78.12 ? 7   ARG A NH2 1 
ATOM   1808 N N   . VAL C 3 8   ? 209.760 229.682 190.208 1.00 71.00 ? 8   VAL A N   1 
ATOM   1809 C CA  . VAL C 3 8   ? 209.040 230.139 189.028 1.00 71.00 ? 8   VAL A CA  1 
ATOM   1810 C C   . VAL C 3 8   ? 210.050 230.564 187.972 1.00 71.00 ? 8   VAL A C   1 
ATOM   1811 O O   . VAL C 3 8   ? 211.209 230.861 188.265 1.00 71.00 ? 8   VAL A O   1 
ATOM   1812 C CB  . VAL C 3 8   ? 208.063 231.295 189.328 1.00 71.00 ? 8   VAL A CB  1 
ATOM   1813 C CG1 . VAL C 3 8   ? 207.160 230.953 190.504 1.00 71.00 ? 8   VAL A CG1 1 
ATOM   1814 C CG2 . VAL C 3 8   ? 208.821 232.589 189.569 1.00 71.00 ? 8   VAL A CG2 1 
ATOM   1815 N N   . PHE C 3 9   ? 209.588 230.591 186.728 1.00 66.51 ? 9   PHE A N   1 
ATOM   1816 C CA  . PHE C 3 9   ? 210.414 230.878 185.567 1.00 66.51 ? 9   PHE A CA  1 
ATOM   1817 C C   . PHE C 3 9   ? 209.924 232.152 184.893 1.00 66.51 ? 9   PHE A C   1 
ATOM   1818 O O   . PHE C 3 9   ? 208.872 232.693 185.237 1.00 66.51 ? 9   PHE A O   1 
ATOM   1819 C CB  . PHE C 3 9   ? 210.410 229.700 184.587 1.00 66.51 ? 9   PHE A CB  1 
ATOM   1820 C CG  . PHE C 3 9   ? 210.634 228.363 185.245 1.00 66.51 ? 9   PHE A CG  1 
ATOM   1821 C CD1 . PHE C 3 9   ? 209.597 227.693 185.874 1.00 66.51 ? 9   PHE A CD1 1 
ATOM   1822 C CD2 . PHE C 3 9   ? 211.890 227.782 185.244 1.00 66.51 ? 9   PHE A CD2 1 
ATOM   1823 C CE1 . PHE C 3 9   ? 209.807 226.470 186.481 1.00 66.51 ? 9   PHE A CE1 1 
ATOM   1824 C CE2 . PHE C 3 9   ? 212.104 226.558 185.850 1.00 66.51 ? 9   PHE A CE2 1 
ATOM   1825 C CZ  . PHE C 3 9   ? 211.061 225.902 186.468 1.00 66.51 ? 9   PHE A CZ  1 
ATOM   1826 N N   . LYS C 3 10  ? 210.699 232.639 183.927 1.00 60.51 ? 10  LYS A N   1 
ATOM   1827 C CA  . LYS C 3 10  ? 210.419 233.949 183.357 1.00 60.51 ? 10  LYS A CA  1 
ATOM   1828 C C   . LYS C 3 10  ? 211.217 234.139 182.077 1.00 60.51 ? 10  LYS A C   1 
ATOM   1829 O O   . LYS C 3 10  ? 212.359 233.687 181.982 1.00 60.51 ? 10  LYS A O   1 
ATOM   1830 C CB  . LYS C 3 10  ? 210.754 235.057 184.368 1.00 60.51 ? 10  LYS A CB  1 
ATOM   1831 C CG  . LYS C 3 10  ? 211.540 236.232 183.812 1.00 60.51 ? 10  LYS A CG  1 
ATOM   1832 C CD  . LYS C 3 10  ? 211.549 237.390 184.794 1.00 60.51 ? 10  LYS A CD  1 
ATOM   1833 C CE  . LYS C 3 10  ? 212.227 238.613 184.204 1.00 60.51 ? 10  LYS A CE  1 
ATOM   1834 N NZ  . LYS C 3 10  ? 213.674 238.373 183.949 1.00 60.51 ? 10  LYS A NZ  1 
ATOM   1835 N N   . LYS C 3 11  ? 210.602 234.801 181.097 1.00 59.71 ? 11  LYS A N   1 
ATOM   1836 C CA  . LYS C 3 11  ? 211.260 235.201 179.859 1.00 59.71 ? 11  LYS A CA  1 
ATOM   1837 C C   . LYS C 3 11  ? 210.868 236.624 179.503 1.00 59.71 ? 11  LYS A C   1 
ATOM   1838 O O   . LYS C 3 11  ? 209.680 236.960 179.491 1.00 59.71 ? 11  LYS A O   1 
ATOM   1839 C CB  . LYS C 3 11  ? 210.909 234.272 178.696 1.00 59.71 ? 11  LYS A CB  1 
ATOM   1840 C CG  . LYS C 3 11  ? 212.039 234.074 177.697 1.00 59.71 ? 11  LYS A CG  1 
ATOM   1841 C CD  . LYS C 3 11  ? 213.165 233.213 178.227 1.00 59.71 ? 11  LYS A CD  1 
ATOM   1842 C CE  . LYS C 3 11  ? 212.685 231.821 178.572 1.00 59.71 ? 11  LYS A CE  1 
ATOM   1843 N NZ  . LYS C 3 11  ? 213.796 231.026 179.150 1.00 59.71 ? 11  LYS A NZ  1 
ATOM   1844 N N   . ALA C 3 12  ? 211.862 237.444 179.202 1.00 60.02 ? 12  ALA A N   1 
ATOM   1845 C CA  . ALA C 3 12  ? 211.653 238.822 178.791 1.00 60.02 ? 12  ALA A CA  1 
ATOM   1846 C C   . ALA C 3 12  ? 211.589 238.896 177.268 1.00 60.02 ? 12  ALA A C   1 
ATOM   1847 O O   . ALA C 3 12  ? 211.429 237.886 176.581 1.00 60.02 ? 12  ALA A O   1 
ATOM   1848 C CB  . ALA C 3 12  ? 212.751 239.716 179.364 1.00 60.02 ? 12  ALA A CB  1 
ATOM   1849 N N   . SER C 3 13  ? 211.708 240.101 176.726 1.00 66.53 ? 13  SER A N   1 
ATOM   1850 C CA  . SER C 3 13  ? 211.647 240.332 175.294 1.00 66.53 ? 13  SER A CA  1 
ATOM   1851 C C   . SER C 3 13  ? 212.816 241.193 174.844 1.00 66.53 ? 13  SER A C   1 
ATOM   1852 O O   . SER C 3 13  ? 213.389 241.937 175.645 1.00 66.53 ? 13  SER A O   1 
ATOM   1853 C CB  . SER C 3 13  ? 210.328 241.015 174.905 1.00 66.53 ? 13  SER A CB  1 
ATOM   1854 O OG  . SER C 3 13  ? 210.084 242.152 175.714 1.00 66.53 ? 13  SER A OG  1 
ATOM   1855 N N   . PRO C 3 14  ? 213.197 241.105 173.565 1.00 67.91 ? 14  PRO A N   1 
ATOM   1856 C CA  . PRO C 3 14  ? 214.293 241.954 173.071 1.00 67.91 ? 14  PRO A CA  1 
ATOM   1857 C C   . PRO C 3 14  ? 214.022 243.441 173.204 1.00 67.91 ? 14  PRO A C   1 
ATOM   1858 O O   . PRO C 3 14  ? 214.965 244.213 173.418 1.00 67.91 ? 14  PRO A O   1 
ATOM   1859 C CB  . PRO C 3 14  ? 214.424 241.534 171.602 1.00 67.91 ? 14  PRO A CB  1 
ATOM   1860 C CG  . PRO C 3 14  ? 213.825 240.179 171.538 1.00 67.91 ? 14  PRO A CG  1 
ATOM   1861 C CD  . PRO C 3 14  ? 212.720 240.169 172.537 1.00 67.91 ? 14  PRO A CD  1 
ATOM   1862 N N   . ASN C 3 15  ? 212.771 243.875 173.074 1.00 70.06 ? 15  ASN A N   1 
ATOM   1863 C CA  . ASN C 3 15  ? 212.412 245.266 173.303 1.00 70.06 ? 15  ASN A CA  1 
ATOM   1864 C C   . ASN C 3 15  ? 211.919 245.525 174.718 1.00 70.06 ? 15  ASN A C   1 
ATOM   1865 O O   . ASN C 3 15  ? 211.619 246.675 175.052 1.00 70.06 ? 15  ASN A O   1 
ATOM   1866 C CB  . ASN C 3 15  ? 211.349 245.720 172.302 1.00 70.06 ? 15  ASN A CB  1 
ATOM   1867 C CG  . ASN C 3 15  ? 211.913 246.636 171.233 1.00 70.06 ? 15  ASN A CG  1 
ATOM   1868 O OD1 . ASN C 3 15  ? 213.097 246.970 171.249 1.00 70.06 ? 15  ASN A OD1 1 
ATOM   1869 N ND2 . ASN C 3 15  ? 211.065 247.046 170.296 1.00 70.06 ? 15  ASN A ND2 1 
ATOM   1870 N N   . GLY C 3 16  ? 211.827 244.495 175.554 1.00 66.30 ? 16  GLY A N   1 
ATOM   1871 C CA  . GLY C 3 16  ? 211.510 244.699 176.951 1.00 66.30 ? 16  GLY A CA  1 
ATOM   1872 C C   . GLY C 3 16  ? 210.165 245.352 177.179 1.00 66.30 ? 16  GLY A C   1 
ATOM   1873 O O   . GLY C 3 16  ? 210.068 246.339 177.912 1.00 66.30 ? 16  GLY A O   1 
ATOM   1874 N N   . LYS C 3 17  ? 209.123 244.830 176.538 1.00 71.08 ? 17  LYS A N   1 
ATOM   1875 C CA  . LYS C 3 17  ? 207.778 245.363 176.704 1.00 71.08 ? 17  LYS A CA  1 
ATOM   1876 C C   . LYS C 3 17  ? 206.816 244.362 177.333 1.00 71.08 ? 17  LYS A C   1 
ATOM   1877 O O   . LYS C 3 17  ? 205.632 244.679 177.487 1.00 71.08 ? 17  LYS A O   1 
ATOM   1878 C CB  . LYS C 3 17  ? 207.228 245.850 175.361 1.00 71.08 ? 17  LYS A CB  1 
ATOM   1879 C CG  . LYS C 3 17  ? 207.999 247.026 174.782 1.00 71.08 ? 17  LYS A CG  1 
ATOM   1880 C CD  . LYS C 3 17  ? 208.169 248.134 175.810 1.00 71.08 ? 17  LYS A CD  1 
ATOM   1881 C CE  . LYS C 3 17  ? 208.933 249.314 175.232 1.00 71.08 ? 17  LYS A CE  1 
ATOM   1882 N NZ  . LYS C 3 17  ? 209.225 250.344 176.266 1.00 71.08 ? 17  LYS A NZ  1 
ATOM   1883 N N   . LEU C 3 18  ? 207.285 243.168 177.697 1.00 61.69 ? 18  LEU A N   1 
ATOM   1884 C CA  . LEU C 3 18  ? 206.446 242.209 178.401 1.00 61.69 ? 18  LEU A CA  1 
ATOM   1885 C C   . LEU C 3 18  ? 207.316 241.136 179.037 1.00 61.69 ? 18  LEU A C   1 
ATOM   1886 O O   . LEU C 3 18  ? 208.500 240.999 178.731 1.00 61.69 ? 18  LEU A O   1 
ATOM   1887 C CB  . LEU C 3 18  ? 205.395 241.581 177.476 1.00 61.69 ? 18  LEU A CB  1 
ATOM   1888 C CG  . LEU C 3 18  ? 205.794 240.745 176.258 1.00 61.69 ? 18  LEU A CG  1 
ATOM   1889 C CD1 . LEU C 3 18  ? 206.159 239.343 176.710 1.00 61.69 ? 18  LEU A CD1 1 
ATOM   1890 C CD2 . LEU C 3 18  ? 204.680 240.677 175.234 1.00 61.69 ? 18  LEU A CD2 1 
ATOM   1891 N N   . THR C 3 19  ? 206.702 240.374 179.937 1.00 57.27 ? 19  THR A N   1 
ATOM   1892 C CA  . THR C 3 19  ? 207.360 239.261 180.605 1.00 57.27 ? 19  THR A CA  1 
ATOM   1893 C C   . THR C 3 19  ? 206.307 238.220 180.941 1.00 57.27 ? 19  THR A C   1 
ATOM   1894 O O   . THR C 3 19  ? 205.173 238.573 181.273 1.00 57.27 ? 19  THR A O   1 
ATOM   1895 C CB  . THR C 3 19  ? 208.076 239.716 181.876 1.00 57.27 ? 19  THR A CB  1 
ATOM   1896 O OG1 . THR C 3 19  ? 208.600 241.036 181.690 1.00 57.27 ? 19  THR A OG1 1 
ATOM   1897 C CG2 . THR C 3 19  ? 209.213 238.767 182.210 1.00 57.27 ? 19  THR A CG2 1 
ATOM   1898 N N   . VAL C 3 20  ? 206.677 236.947 180.848 1.00 55.51 ? 20  VAL A N   1 
ATOM   1899 C CA  . VAL C 3 20  ? 205.771 235.833 181.095 1.00 55.51 ? 20  VAL A CA  1 
ATOM   1900 C C   . VAL C 3 20  ? 206.367 234.963 182.190 1.00 55.51 ? 20  VAL A C   1 
ATOM   1901 O O   . VAL C 3 20  ? 207.559 234.640 182.150 1.00 55.51 ? 20  VAL A O   1 
ATOM   1902 C CB  . VAL C 3 20  ? 205.524 235.008 179.820 1.00 55.51 ? 20  VAL A CB  1 
ATOM   1903 C CG1 . VAL C 3 20  ? 204.542 233.886 180.097 1.00 55.51 ? 20  VAL A CG1 1 
ATOM   1904 C CG2 . VAL C 3 20  ? 205.005 235.896 178.715 1.00 55.51 ? 20  VAL A CG2 1 
ATOM   1905 N N   . TYR C 3 21  ? 205.544 234.585 183.158 1.00 56.56 ? 21  TYR A N   1 
ATOM   1906 C CA  . TYR C 3 21  ? 205.978 233.776 184.283 1.00 56.56 ? 21  TYR A CA  1 
ATOM   1907 C C   . TYR C 3 21  ? 205.157 232.497 184.350 1.00 56.56 ? 21  TYR A C   1 
ATOM   1908 O O   . TYR C 3 21  ? 203.975 232.482 184.000 1.00 56.56 ? 21  TYR A O   1 
ATOM   1909 C CB  . TYR C 3 21  ? 205.842 234.542 185.606 1.00 56.56 ? 21  TYR A CB  1 
ATOM   1910 C CG  . TYR C 3 21  ? 206.418 235.939 185.581 1.00 56.56 ? 21  TYR A CG  1 
ATOM   1911 C CD1 . TYR C 3 21  ? 205.676 237.008 185.105 1.00 56.56 ? 21  TYR A CD1 1 
ATOM   1912 C CD2 . TYR C 3 21  ? 207.698 236.189 186.041 1.00 56.56 ? 21  TYR A CD2 1 
ATOM   1913 C CE1 . TYR C 3 21  ? 206.198 238.282 185.082 1.00 56.56 ? 21  TYR A CE1 1 
ATOM   1914 C CE2 . TYR C 3 21  ? 208.225 237.459 186.022 1.00 56.56 ? 21  TYR A CE2 1 
ATOM   1915 C CZ  . TYR C 3 21  ? 207.472 238.501 185.542 1.00 56.56 ? 21  TYR A CZ  1 
ATOM   1916 O OH  . TYR C 3 21  ? 207.997 239.769 185.523 1.00 56.56 ? 21  TYR A OH  1 
ATOM   1917 N N   . LEU C 3 22  ? 205.792 231.421 184.807 1.00 58.70 ? 22  LEU A N   1 
ATOM   1918 C CA  . LEU C 3 22  ? 205.131 230.130 184.916 1.00 58.70 ? 22  LEU A CA  1 
ATOM   1919 C C   . LEU C 3 22  ? 205.652 229.392 186.137 1.00 58.70 ? 22  LEU A C   1 
ATOM   1920 O O   . LEU C 3 22  ? 206.751 229.661 186.624 1.00 58.70 ? 22  LEU A O   1 
ATOM   1921 C CB  . LEU C 3 22  ? 205.340 229.270 183.665 1.00 58.70 ? 22  LEU A CB  1 
ATOM   1922 C CG  . LEU C 3 22  ? 204.502 229.634 182.444 1.00 58.70 ? 22  LEU A CG  1 
ATOM   1923 C CD1 . LEU C 3 22  ? 205.158 229.149 181.175 1.00 58.70 ? 22  LEU A CD1 1 
ATOM   1924 C CD2 . LEU C 3 22  ? 203.108 229.063 182.577 1.00 58.70 ? 22  LEU A CD2 1 
ATOM   1925 N N   . GLY C 3 23  ? 204.847 228.455 186.625 1.00 64.15 ? 23  GLY A N   1 
ATOM   1926 C CA  . GLY C 3 23  ? 205.207 227.706 187.809 1.00 64.15 ? 23  GLY A CA  1 
ATOM   1927 C C   . GLY C 3 23  ? 205.902 226.397 187.509 1.00 64.15 ? 23  GLY A C   1 
ATOM   1928 O O   . GLY C 3 23  ? 206.502 225.792 188.402 1.00 64.15 ? 23  GLY A O   1 
ATOM   1929 N N   . LYS C 3 24  ? 205.836 225.948 186.258 1.00 66.48 ? 24  LYS A N   1 
ATOM   1930 C CA  . LYS C 3 24  ? 206.381 224.654 185.876 1.00 66.48 ? 24  LYS A CA  1 
ATOM   1931 C C   . LYS C 3 24  ? 206.921 224.720 184.457 1.00 66.48 ? 24  LYS A C   1 
ATOM   1932 O O   . LYS C 3 24  ? 206.642 225.652 183.699 1.00 66.48 ? 24  LYS A O   1 
ATOM   1933 C CB  . LYS C 3 24  ? 205.330 223.543 185.983 1.00 66.48 ? 24  LYS A CB  1 
ATOM   1934 C CG  . LYS C 3 24  ? 205.029 223.091 187.400 1.00 66.48 ? 24  LYS A CG  1 
ATOM   1935 C CD  . LYS C 3 24  ? 203.866 222.116 187.426 1.00 66.48 ? 24  LYS A CD  1 
ATOM   1936 C CE  . LYS C 3 24  ? 202.688 222.639 186.622 1.00 66.48 ? 24  LYS A CE  1 
ATOM   1937 N NZ  . LYS C 3 24  ? 201.721 221.558 186.291 1.00 66.48 ? 24  LYS A NZ  1 
ATOM   1938 N N   . ARG C 3 25  ? 207.713 223.709 184.108 1.00 68.79 ? 25  ARG A N   1 
ATOM   1939 C CA  . ARG C 3 25  ? 208.208 223.511 182.752 1.00 68.79 ? 25  ARG A CA  1 
ATOM   1940 C C   . ARG C 3 25  ? 207.360 222.516 181.974 1.00 68.79 ? 25  ARG A C   1 
ATOM   1941 O O   . ARG C 3 25  ? 206.861 222.835 180.892 1.00 68.79 ? 25  ARG A O   1 
ATOM   1942 C CB  . ARG C 3 25  ? 209.662 223.021 182.784 1.00 68.79 ? 25  ARG A CB  1 
ATOM   1943 C CG  . ARG C 3 25  ? 210.651 223.961 183.450 1.00 68.79 ? 25  ARG A CG  1 
ATOM   1944 C CD  . ARG C 3 25  ? 212.001 223.895 182.748 1.00 68.79 ? 25  ARG A CD  1 
ATOM   1945 N NE  . ARG C 3 25  ? 212.952 224.865 183.277 1.00 68.79 ? 25  ARG A NE  1 
ATOM   1946 C CZ  . ARG C 3 25  ? 214.070 224.546 183.915 1.00 68.79 ? 25  ARG A CZ  1 
ATOM   1947 N NH1 . ARG C 3 25  ? 214.410 223.285 184.125 1.00 68.79 ? 25  ARG A NH1 1 
ATOM   1948 N NH2 . ARG C 3 25  ? 214.867 225.516 184.353 1.00 68.79 ? 25  ARG A NH2 1 
ATOM   1949 N N   . ASP C 3 26  ? 207.193 221.311 182.507 1.00 67.81 ? 26  ASP A N   1 
ATOM   1950 C CA  . ASP C 3 26  ? 206.453 220.240 181.856 1.00 67.81 ? 26  ASP A CA  1 
ATOM   1951 C C   . ASP C 3 26  ? 205.173 219.976 182.632 1.00 67.81 ? 26  ASP A C   1 
ATOM   1952 O O   . ASP C 3 26  ? 205.199 219.883 183.863 1.00 67.81 ? 26  ASP A O   1 
ATOM   1953 C CB  . ASP C 3 26  ? 207.294 218.966 181.775 1.00 67.81 ? 26  ASP A CB  1 
ATOM   1954 C CG  . ASP C 3 26  ? 208.672 219.215 181.197 1.00 67.81 ? 26  ASP A CG  1 
ATOM   1955 O OD1 . ASP C 3 26  ? 208.840 220.210 180.460 1.00 67.81 ? 26  ASP A OD1 1 
ATOM   1956 O OD2 . ASP C 3 26  ? 209.591 218.421 181.487 1.00 67.81 ? 26  ASP A OD2 1 
ATOM   1957 N N   . PHE C 3 27  ? 204.064 219.851 181.916 1.00 62.70 ? 27  PHE A N   1 
ATOM   1958 C CA  . PHE C 3 27  ? 202.748 219.717 182.521 1.00 62.70 ? 27  PHE A CA  1 
ATOM   1959 C C   . PHE C 3 27  ? 202.291 218.273 182.389 1.00 62.70 ? 27  PHE A C   1 
ATOM   1960 O O   . PHE C 3 27  ? 202.166 217.759 181.274 1.00 62.70 ? 27  PHE A O   1 
ATOM   1961 C CB  . PHE C 3 27  ? 201.752 220.670 181.864 1.00 62.70 ? 27  PHE A CB  1 
ATOM   1962 C CG  . PHE C 3 27  ? 202.075 222.115 182.079 1.00 62.70 ? 27  PHE A CG  1 
ATOM   1963 C CD1 . PHE C 3 27  ? 203.064 222.732 181.340 1.00 62.70 ? 27  PHE A CD1 1 
ATOM   1964 C CD2 . PHE C 3 27  ? 201.396 222.855 183.022 1.00 62.70 ? 27  PHE A CD2 1 
ATOM   1965 C CE1 . PHE C 3 27  ? 203.368 224.054 181.538 1.00 62.70 ? 27  PHE A CE1 1 
ATOM   1966 C CE2 . PHE C 3 27  ? 201.698 224.182 183.220 1.00 62.70 ? 27  PHE A CE2 1 
ATOM   1967 C CZ  . PHE C 3 27  ? 202.687 224.779 182.477 1.00 62.70 ? 27  PHE A CZ  1 
ATOM   1968 N N   . VAL C 3 28  ? 202.039 217.627 183.527 1.00 64.03 ? 28  VAL A N   1 
ATOM   1969 C CA  . VAL C 3 28  ? 201.718 216.208 183.515 1.00 64.03 ? 28  VAL A CA  1 
ATOM   1970 C C   . VAL C 3 28  ? 200.348 215.984 182.887 1.00 64.03 ? 28  VAL A C   1 
ATOM   1971 O O   . VAL C 3 28  ? 199.525 216.896 182.763 1.00 64.03 ? 28  VAL A O   1 
ATOM   1972 C CB  . VAL C 3 28  ? 201.779 215.625 184.935 1.00 64.03 ? 28  VAL A CB  1 
ATOM   1973 C CG1 . VAL C 3 28  ? 203.004 216.143 185.666 1.00 64.03 ? 28  VAL A CG1 1 
ATOM   1974 C CG2 . VAL C 3 28  ? 200.520 215.972 185.698 1.00 64.03 ? 28  VAL A CG2 1 
ATOM   1975 N N   . ASP C 3 29  ? 200.108 214.744 182.477 1.00 68.13 ? 29  ASP A N   1 
ATOM   1976 C CA  . ASP C 3 29  ? 198.849 214.341 181.860 1.00 68.13 ? 29  ASP A CA  1 
ATOM   1977 C C   . ASP C 3 29  ? 198.258 213.203 182.683 1.00 68.13 ? 29  ASP A C   1 
ATOM   1978 O O   . ASP C 3 29  ? 198.803 212.094 182.697 1.00 68.13 ? 29  ASP A O   1 
ATOM   1979 C CB  . ASP C 3 29  ? 199.065 213.927 180.407 1.00 68.13 ? 29  ASP A CB  1 
ATOM   1980 C CG  . ASP C 3 29  ? 197.787 213.486 179.729 1.00 68.13 ? 29  ASP A CG  1 
ATOM   1981 O OD1 . ASP C 3 29  ? 196.697 213.859 180.209 1.00 68.13 ? 29  ASP A OD1 1 
ATOM   1982 O OD2 . ASP C 3 29  ? 197.870 212.764 178.714 1.00 68.13 ? 29  ASP A OD2 1 
ATOM   1983 N N   . HIS C 3 30  ? 197.142 213.476 183.362 1.00 71.62 ? 30  HIS A N   1 
ATOM   1984 C CA  . HIS C 3 30  ? 196.497 212.510 184.244 1.00 71.62 ? 30  HIS A CA  1 
ATOM   1985 C C   . HIS C 3 30  ? 195.454 211.664 183.529 1.00 71.62 ? 30  HIS A C   1 
ATOM   1986 O O   . HIS C 3 30  ? 194.485 211.223 184.163 1.00 71.62 ? 30  HIS A O   1 
ATOM   1987 C CB  . HIS C 3 30  ? 195.860 213.225 185.436 1.00 71.62 ? 30  HIS A CB  1 
ATOM   1988 C CG  . HIS C 3 30  ? 196.849 213.820 186.386 1.00 71.62 ? 30  HIS A CG  1 
ATOM   1989 N ND1 . HIS C 3 30  ? 197.745 213.057 187.102 1.00 71.62 ? 30  HIS A ND1 1 
ATOM   1990 C CD2 . HIS C 3 30  ? 197.075 215.104 186.748 1.00 71.62 ? 30  HIS A CD2 1 
ATOM   1991 C CE1 . HIS C 3 30  ? 198.485 213.845 187.860 1.00 71.62 ? 30  HIS A CE1 1 
ATOM   1992 N NE2 . HIS C 3 30  ? 198.097 215.093 187.666 1.00 71.62 ? 30  HIS A NE2 1 
ATOM   1993 N N   . ILE C 3 31  ? 195.614 211.450 182.223 1.00 72.72 ? 31  ILE A N   1 
ATOM   1994 C CA  . ILE C 3 31  ? 194.696 210.656 181.410 1.00 72.72 ? 31  ILE A CA  1 
ATOM   1995 C C   . ILE C 3 31  ? 193.331 211.332 181.366 1.00 72.72 ? 31  ILE A C   1 
ATOM   1996 O O   . ILE C 3 31  ? 192.883 211.777 180.303 1.00 72.72 ? 31  ILE A O   1 
ATOM   1997 C CB  . ILE C 3 31  ? 194.584 209.208 181.926 1.00 72.72 ? 31  ILE A CB  1 
ATOM   1998 C CG1 . ILE C 3 31  ? 195.867 208.430 181.631 1.00 72.72 ? 31  ILE A CG1 1 
ATOM   1999 C CG2 . ILE C 3 31  ? 193.395 208.503 181.290 1.00 72.72 ? 31  ILE A CG2 1 
ATOM   2000 C CD1 . ILE C 3 31  ? 196.898 208.493 182.739 1.00 72.72 ? 31  ILE A CD1 1 
ATOM   2001 N N   . ASP C 3 32  ? 192.659 211.414 182.516 1.00 73.95 ? 32  ASP A N   1 
ATOM   2002 C CA  . ASP C 3 32  ? 191.337 212.033 182.560 1.00 73.95 ? 32  ASP A CA  1 
ATOM   2003 C C   . ASP C 3 32  ? 191.417 213.536 182.322 1.00 73.95 ? 32  ASP A C   1 
ATOM   2004 O O   . ASP C 3 32  ? 190.564 214.107 181.633 1.00 73.95 ? 32  ASP A O   1 
ATOM   2005 C CB  . ASP C 3 32  ? 190.667 211.737 183.901 1.00 73.95 ? 32  ASP A CB  1 
ATOM   2006 C CG  . ASP C 3 32  ? 189.209 212.150 183.928 1.00 73.95 ? 32  ASP A CG  1 
ATOM   2007 O OD1 . ASP C 3 32  ? 188.586 212.210 182.847 1.00 73.95 ? 32  ASP A OD1 1 
ATOM   2008 O OD2 . ASP C 3 32  ? 188.686 212.415 185.031 1.00 73.95 ? 32  ASP A OD2 1 
ATOM   2009 N N   . LEU C 3 33  ? 192.433 214.192 182.878 1.00 71.22 ? 33  LEU A N   1 
ATOM   2010 C CA  . LEU C 3 33  ? 192.583 215.632 182.732 1.00 71.22 ? 33  LEU A CA  1 
ATOM   2011 C C   . LEU C 3 33  ? 194.063 215.981 182.696 1.00 71.22 ? 33  LEU A C   1 
ATOM   2012 O O   . LEU C 3 33  ? 194.917 215.201 183.122 1.00 71.22 ? 33  LEU A O   1 
ATOM   2013 C CB  . LEU C 3 33  ? 191.880 216.388 183.865 1.00 71.22 ? 33  LEU A CB  1 
ATOM   2014 C CG  . LEU C 3 33  ? 192.633 216.500 185.191 1.00 71.22 ? 33  LEU A CG  1 
ATOM   2015 C CD1 . LEU C 3 33  ? 192.120 217.682 185.997 1.00 71.22 ? 33  LEU A CD1 1 
ATOM   2016 C CD2 . LEU C 3 33  ? 192.513 215.213 185.994 1.00 71.22 ? 33  LEU A CD2 1 
ATOM   2017 N N   . VAL C 3 34  ? 194.356 217.167 182.172 1.00 69.12 ? 34  VAL A N   1 
ATOM   2018 C CA  . VAL C 3 34  ? 195.714 217.684 182.076 1.00 69.12 ? 34  VAL A CA  1 
ATOM   2019 C C   . VAL C 3 34  ? 195.811 218.929 182.943 1.00 69.12 ? 34  VAL A C   1 
ATOM   2020 O O   . VAL C 3 34  ? 194.885 219.748 182.972 1.00 69.12 ? 34  VAL A O   1 
ATOM   2021 C CB  . VAL C 3 34  ? 196.101 218.002 180.620 1.00 69.12 ? 34  VAL A CB  1 
ATOM   2022 C CG1 . VAL C 3 34  ? 197.593 218.260 180.515 1.00 69.12 ? 34  VAL A CG1 1 
ATOM   2023 C CG2 . VAL C 3 34  ? 195.679 216.870 179.698 1.00 69.12 ? 34  VAL A CG2 1 
ATOM   2024 N N   . ASP C 3 35  ? 196.911 219.018 183.701 1.00 69.50 ? 35  ASP A N   1 
ATOM   2025 C CA  . ASP C 3 35  ? 197.124 220.168 184.617 1.00 69.50 ? 35  ASP A CA  1 
ATOM   2026 C C   . ASP C 3 35  ? 197.074 221.471 183.820 1.00 69.50 ? 35  ASP A C   1 
ATOM   2027 O O   . ASP C 3 35  ? 197.669 221.523 182.725 1.00 69.50 ? 35  ASP A O   1 
ATOM   2028 C CB  . ASP C 3 35  ? 198.459 220.042 185.353 1.00 30.00 ? 35  ASP A CB  1 
ATOM   2029 C CG  . ASP C 3 35  ? 198.456 218.948 186.404 1.00 30.00 ? 35  ASP A CG  1 
ATOM   2030 O OD1 . ASP C 3 35  ? 197.472 218.185 186.447 1.00 30.00 ? 35  ASP A OD1 1 
ATOM   2031 O OD2 . ASP C 3 35  ? 199.435 218.871 187.172 1.00 30.00 ? 35  ASP A OD2 1 
ATOM   2032 N N   . PRO C 3 36  ? 196.411 222.530 184.331 1.00 66.51 ? 36  PRO A N   1 
ATOM   2033 C CA  . PRO C 3 36  ? 196.287 223.784 183.587 1.00 66.51 ? 36  PRO A CA  1 
ATOM   2034 C C   . PRO C 3 36  ? 197.584 224.575 183.579 1.00 66.51 ? 36  PRO A C   1 
ATOM   2035 O O   . PRO C 3 36  ? 198.495 224.349 184.377 1.00 66.51 ? 36  PRO A O   1 
ATOM   2036 C CB  . PRO C 3 36  ? 195.191 224.533 184.347 1.00 66.51 ? 36  PRO A CB  1 
ATOM   2037 C CG  . PRO C 3 36  ? 195.332 224.044 185.745 1.00 66.51 ? 36  PRO A CG  1 
ATOM   2038 C CD  . PRO C 3 36  ? 195.760 222.602 185.649 1.00 66.51 ? 36  PRO A CD  1 
ATOM   2039 N N   . VAL C 3 37  ? 197.649 225.525 182.648 1.00 63.45 ? 37  VAL A N   1 
ATOM   2040 C CA  . VAL C 3 37  ? 198.789 226.425 182.514 1.00 63.45 ? 37  VAL A CA  1 
ATOM   2041 C C   . VAL C 3 37  ? 198.442 227.699 183.277 1.00 63.45 ? 37  VAL A C   1 
ATOM   2042 O O   . VAL C 3 37  ? 197.683 228.541 182.796 1.00 63.45 ? 37  VAL A O   1 
ATOM   2043 C CB  . VAL C 3 37  ? 199.110 226.713 181.049 1.00 63.45 ? 37  VAL A CB  1 
ATOM   2044 C CG1 . VAL C 3 37  ? 200.536 227.193 180.908 1.00 63.45 ? 37  VAL A CG1 1 
ATOM   2045 C CG2 . VAL C 3 37  ? 198.880 225.473 180.208 1.00 63.45 ? 37  VAL A CG2 1 
ATOM   2046 N N   . ASP C 3 38  ? 199.001 227.838 184.476 1.00 65.54 ? 38  ASP A N   1 
ATOM   2047 C CA  . ASP C 3 38  ? 198.678 228.953 185.364 1.00 65.54 ? 38  ASP A CA  1 
ATOM   2048 C C   . ASP C 3 38  ? 199.723 230.066 185.253 1.00 65.54 ? 38  ASP A C   1 
ATOM   2049 O O   . ASP C 3 38  ? 200.447 230.406 186.188 1.00 65.54 ? 38  ASP A O   1 
ATOM   2050 C CB  . ASP C 3 38  ? 198.479 228.434 186.792 1.00 65.54 ? 38  ASP A CB  1 
ATOM   2051 C CG  . ASP C 3 38  ? 199.775 227.995 187.475 1.00 65.54 ? 38  ASP A CG  1 
ATOM   2052 O OD1 . ASP C 3 38  ? 199.703 227.604 188.659 1.00 65.54 ? 38  ASP A OD1 1 
ATOM   2053 O OD2 . ASP C 3 38  ? 200.843 227.950 186.829 1.00 65.54 ? 38  ASP A OD2 1 
ATOM   2054 N N   . GLY C 3 39  ? 199.738 230.693 184.082 1.00 59.13 ? 39  GLY A N   1 
ATOM   2055 C CA  . GLY C 3 39  ? 200.722 231.710 183.793 1.00 59.13 ? 39  GLY A CA  1 
ATOM   2056 C C   . GLY C 3 39  ? 200.425 233.045 184.452 1.00 59.13 ? 39  GLY A C   1 
ATOM   2057 O O   . GLY C 3 39  ? 199.407 233.246 185.111 1.00 59.13 ? 39  GLY A O   1 
ATOM   2058 N N   . VAL C 3 40  ? 201.364 233.973 184.266 1.00 55.38 ? 40  VAL A N   1 
ATOM   2059 C CA  . VAL C 3 40  ? 201.242 235.350 184.726 1.00 55.38 ? 40  VAL A CA  1 
ATOM   2060 C C   . VAL C 3 40  ? 201.955 236.230 183.713 1.00 55.38 ? 40  VAL A C   1 
ATOM   2061 O O   . VAL C 3 40  ? 202.977 235.839 183.149 1.00 55.38 ? 40  VAL A O   1 
ATOM   2062 C CB  . VAL C 3 40  ? 201.831 235.534 186.144 1.00 55.38 ? 40  VAL A CB  1 
ATOM   2063 C CG1 . VAL C 3 40  ? 202.173 236.988 186.404 1.00 55.38 ? 40  VAL A CG1 1 
ATOM   2064 C CG2 . VAL C 3 40  ? 200.863 235.028 187.198 1.00 55.38 ? 40  VAL A CG2 1 
ATOM   2065 N N   . VAL C 3 41  ? 201.405 237.413 183.459 1.00 55.39 ? 41  VAL A N   1 
ATOM   2066 C CA  . VAL C 3 41  ? 201.995 238.348 182.511 1.00 55.39 ? 41  VAL A CA  1 
ATOM   2067 C C   . VAL C 3 41  ? 202.152 239.702 183.184 1.00 55.39 ? 41  VAL A C   1 
ATOM   2068 O O   . VAL C 3 41  ? 201.242 240.164 183.881 1.00 55.39 ? 41  VAL A O   1 
ATOM   2069 C CB  . VAL C 3 41  ? 201.161 238.469 181.220 1.00 55.39 ? 41  VAL A CB  1 
ATOM   2070 C CG1 . VAL C 3 41  ? 199.711 238.782 181.535 1.00 55.39 ? 41  VAL A CG1 1 
ATOM   2071 C CG2 . VAL C 3 41  ? 201.748 239.524 180.307 1.00 55.39 ? 41  VAL A CG2 1 
ATOM   2072 N N   . LEU C 3 42  ? 203.317 240.321 182.997 1.00 61.11 ? 42  LEU A N   1 
ATOM   2073 C CA  . LEU C 3 42  ? 203.588 241.687 183.428 1.00 61.11 ? 42  LEU A CA  1 
ATOM   2074 C C   . LEU C 3 42  ? 203.871 242.517 182.189 1.00 61.11 ? 42  LEU A C   1 
ATOM   2075 O O   . LEU C 3 42  ? 204.689 242.124 181.353 1.00 61.11 ? 42  LEU A O   1 
ATOM   2076 C CB  . LEU C 3 42  ? 204.767 241.741 184.403 1.00 61.11 ? 42  LEU A CB  1 
ATOM   2077 C CG  . LEU C 3 42  ? 205.348 243.095 184.825 1.00 61.11 ? 42  LEU A CG  1 
ATOM   2078 C CD1 . LEU C 3 42  ? 205.973 242.979 186.195 1.00 61.11 ? 42  LEU A CD1 1 
ATOM   2079 C CD2 . LEU C 3 42  ? 206.402 243.593 183.846 1.00 61.11 ? 42  LEU A CD2 1 
ATOM   2080 N N   . VAL C 3 43  ? 203.213 243.664 182.078 1.00 66.02 ? 43  VAL A N   1 
ATOM   2081 C CA  . VAL C 3 43  ? 203.323 244.493 180.889 1.00 66.02 ? 43  VAL A CA  1 
ATOM   2082 C C   . VAL C 3 43  ? 203.625 245.923 181.304 1.00 66.02 ? 43  VAL A C   1 
ATOM   2083 O O   . VAL C 3 43  ? 203.213 246.381 182.373 1.00 66.02 ? 43  VAL A O   1 
ATOM   2084 C CB  . VAL C 3 43  ? 202.041 244.419 180.029 1.00 66.02 ? 43  VAL A CB  1 
ATOM   2085 C CG1 . VAL C 3 43  ? 200.842 244.972 180.791 1.00 66.02 ? 43  VAL A CG1 1 
ATOM   2086 C CG2 . VAL C 3 43  ? 202.230 245.135 178.700 1.00 66.02 ? 43  VAL A CG2 1 
ATOM   2087 N N   . ASP C 3 44  ? 204.383 246.620 180.458 1.00 77.04 ? 44  ASP A N   1 
ATOM   2088 C CA  . ASP C 3 44  ? 204.637 248.041 180.634 1.00 77.04 ? 44  ASP A CA  1 
ATOM   2089 C C   . ASP C 3 44  ? 203.716 248.812 179.704 1.00 77.04 ? 44  ASP A C   1 
ATOM   2090 O O   . ASP C 3 44  ? 203.897 248.748 178.479 1.00 77.04 ? 44  ASP A O   1 
ATOM   2091 C CB  . ASP C 3 44  ? 206.097 248.373 180.337 1.00 77.04 ? 44  ASP A CB  1 
ATOM   2092 C CG  . ASP C 3 44  ? 206.445 249.813 180.661 1.00 77.04 ? 44  ASP A CG  1 
ATOM   2093 O OD1 . ASP C 3 44  ? 205.702 250.446 181.439 1.00 77.04 ? 44  ASP A OD1 1 
ATOM   2094 O OD2 . ASP C 3 44  ? 207.462 250.313 180.135 1.00 77.04 ? 44  ASP A OD2 1 
ATOM   2095 N N   . PRO C 3 45  ? 202.730 249.549 180.220 1.00 75.13 ? 45  PRO A N   1 
ATOM   2096 C CA  . PRO C 3 45  ? 201.745 250.186 179.334 1.00 75.13 ? 45  PRO A CA  1 
ATOM   2097 C C   . PRO C 3 45  ? 202.266 251.401 178.591 1.00 75.13 ? 45  PRO A C   1 
ATOM   2098 O O   . PRO C 3 45  ? 201.518 251.963 177.785 1.00 75.13 ? 45  PRO A O   1 
ATOM   2099 C CB  . PRO C 3 45  ? 200.615 250.583 180.296 1.00 75.13 ? 45  PRO A CB  1 
ATOM   2100 C CG  . PRO C 3 45  ? 200.888 249.831 181.570 1.00 75.13 ? 45  PRO A CG  1 
ATOM   2101 C CD  . PRO C 3 45  ? 202.366 249.692 181.636 1.00 75.13 ? 45  PRO A CD  1 
ATOM   2102 N N   . GLU C 3 46  ? 203.506 251.830 178.832 1.00 80.72 ? 46  GLU A N   1 
ATOM   2103 C CA  . GLU C 3 46  ? 203.977 253.086 178.253 1.00 80.72 ? 46  GLU A CA  1 
ATOM   2104 C C   . GLU C 3 46  ? 204.023 253.021 176.728 1.00 80.72 ? 46  GLU A C   1 
ATOM   2105 O O   . GLU C 3 46  ? 203.457 253.881 176.043 1.00 80.72 ? 46  GLU A O   1 
ATOM   2106 C CB  . GLU C 3 46  ? 205.349 253.443 178.824 1.00 80.72 ? 46  GLU A CB  1 
ATOM   2107 C CG  . GLU C 3 46  ? 205.753 254.890 178.595 1.00 80.72 ? 46  GLU A CG  1 
ATOM   2108 C CD  . GLU C 3 46  ? 204.864 255.870 179.340 1.00 80.72 ? 46  GLU A CD  1 
ATOM   2109 O OE1 . GLU C 3 46  ? 204.289 255.487 180.381 1.00 80.72 ? 46  GLU A OE1 1 
ATOM   2110 O OE2 . GLU C 3 46  ? 204.738 257.026 178.883 1.00 80.72 ? 46  GLU A OE2 1 
ATOM   2111 N N   . TYR C 3 47  ? 204.692 252.004 176.174 1.00 78.27 ? 47  TYR A N   1 
ATOM   2112 C CA  . TYR C 3 47  ? 204.689 251.834 174.722 1.00 78.27 ? 47  TYR A CA  1 
ATOM   2113 C C   . TYR C 3 47  ? 203.338 251.334 174.235 1.00 78.27 ? 47  TYR A C   1 
ATOM   2114 O O   . TYR C 3 47  ? 202.895 251.683 173.134 1.00 78.27 ? 47  TYR A O   1 
ATOM   2115 C CB  . TYR C 3 47  ? 205.792 250.866 174.292 1.00 78.27 ? 47  TYR A CB  1 
ATOM   2116 C CG  . TYR C 3 47  ? 205.490 250.149 172.990 1.00 78.27 ? 47  TYR A CG  1 
ATOM   2117 C CD1 . TYR C 3 47  ? 205.727 250.761 171.767 1.00 78.27 ? 47  TYR A CD1 1 
ATOM   2118 C CD2 . TYR C 3 47  ? 204.958 248.863 172.984 1.00 78.27 ? 47  TYR A CD2 1 
ATOM   2119 C CE1 . TYR C 3 47  ? 205.446 250.112 170.575 1.00 78.27 ? 47  TYR A CE1 1 
ATOM   2120 C CE2 . TYR C 3 47  ? 204.671 248.209 171.795 1.00 78.27 ? 47  TYR A CE2 1 
ATOM   2121 C CZ  . TYR C 3 47  ? 204.919 248.838 170.595 1.00 78.27 ? 47  TYR A CZ  1 
ATOM   2122 O OH  . TYR C 3 47  ? 204.641 248.196 169.412 1.00 78.27 ? 47  TYR A OH  1 
ATOM   2123 N N   . LEU C 3 48  ? 202.714 250.452 175.030 1.00 76.54 ? 48  LEU A N   1 
ATOM   2124 C CA  . LEU C 3 48  ? 201.408 249.842 174.654 1.00 76.54 ? 48  LEU A CA  1 
ATOM   2125 C C   . LEU C 3 48  ? 200.278 250.750 175.130 1.00 76.54 ? 48  LEU A C   1 
ATOM   2126 O O   . LEU C 3 48  ? 199.218 250.223 175.521 1.00 76.54 ? 48  LEU A O   1 
ATOM   2127 C CB  . LEU C 3 48  ? 201.302 248.481 175.344 1.00 76.54 ? 48  LEU A CB  1 
ATOM   2128 C CG  . LEU C 3 48  ? 200.721 247.364 174.483 1.00 76.54 ? 48  LEU A CG  1 
ATOM   2129 C CD1 . LEU C 3 48  ? 201.625 247.111 173.294 1.00 76.54 ? 48  LEU A CD1 1 
ATOM   2130 C CD2 . LEU C 3 48  ? 200.529 246.093 175.294 1.00 76.54 ? 48  LEU A CD2 1 
ATOM   2131 N N   . LYS C 3 49  ? 200.494 252.060 175.085 1.00 79.34 ? 49  LYS A N   1 
ATOM   2132 C CA  . LYS C 3 49  ? 199.515 253.007 175.614 1.00 79.34 ? 49  LYS A CA  1 
ATOM   2133 C C   . LYS C 3 49  ? 198.171 252.904 174.906 1.00 79.34 ? 49  LYS A C   1 
ATOM   2134 O O   . LYS C 3 49  ? 197.130 253.180 175.512 1.00 79.34 ? 49  LYS A O   1 
ATOM   2135 C CB  . LYS C 3 49  ? 200.062 254.429 175.502 1.00 79.34 ? 49  LYS A CB  1 
ATOM   2136 C CG  . LYS C 3 49  ? 200.450 254.826 174.091 1.00 79.34 ? 49  LYS A CG  1 
ATOM   2137 C CD  . LYS C 3 49  ? 201.033 256.224 174.052 1.00 79.34 ? 49  LYS A CD  1 
ATOM   2138 C CE  . LYS C 3 49  ? 201.396 256.625 172.632 1.00 79.34 ? 49  LYS A CE  1 
ATOM   2139 N NZ  . LYS C 3 49  ? 202.034 257.969 172.580 1.00 79.34 ? 49  LYS A NZ  1 
ATOM   2140 N N   . GLU C 3 50  ? 198.167 252.510 173.635 1.00 77.01 ? 50  GLU A N   1 
ATOM   2141 C CA  . GLU C 3 50  ? 196.930 252.288 172.905 1.00 77.01 ? 50  GLU A CA  1 
ATOM   2142 C C   . GLU C 3 50  ? 196.647 250.822 172.644 1.00 77.01 ? 50  GLU A C   1 
ATOM   2143 O O   . GLU C 3 50  ? 195.482 250.425 172.623 1.00 77.01 ? 50  GLU A O   1 
ATOM   2144 C CB  . GLU C 3 50  ? 196.965 253.036 171.564 1.00 77.01 ? 50  GLU A CB  1 
ATOM   2145 C CG  . GLU C 3 50  ? 195.691 253.006 170.691 1.00 77.01 ? 50  GLU A CG  1 
ATOM   2146 C CD  . GLU C 3 50  ? 194.366 252.873 171.444 1.00 77.01 ? 50  GLU A CD  1 
ATOM   2147 O OE1 . GLU C 3 50  ? 193.405 252.358 170.834 1.00 77.01 ? 50  GLU A OE1 1 
ATOM   2148 O OE2 . GLU C 3 50  ? 194.241 253.341 172.597 1.00 77.01 ? 50  GLU A OE2 1 
ATOM   2149 N N   . ARG C 3 51  ? 197.684 250.007 172.485 1.00 76.48 ? 51  ARG A N   1 
ATOM   2150 C CA  . ARG C 3 51  ? 197.538 248.635 172.018 1.00 76.48 ? 51  ARG A CA  1 
ATOM   2151 C C   . ARG C 3 51  ? 197.070 247.725 173.157 1.00 76.48 ? 51  ARG A C   1 
ATOM   2152 O O   . ARG C 3 51  ? 196.716 248.177 174.249 1.00 76.48 ? 51  ARG A O   1 
ATOM   2153 C CB  . ARG C 3 51  ? 198.851 248.158 171.400 1.00 76.48 ? 51  ARG A CB  1 
ATOM   2154 C CG  . ARG C 3 51  ? 199.712 249.279 170.828 1.00 76.48 ? 51  ARG A CG  1 
ATOM   2155 C CD  . ARG C 3 51  ? 200.873 248.737 170.004 1.00 76.48 ? 51  ARG A CD  1 
ATOM   2156 N NE  . ARG C 3 51  ? 201.897 249.748 169.763 1.00 76.48 ? 51  ARG A NE  1 
ATOM   2157 C CZ  . ARG C 3 51  ? 202.273 250.162 168.560 1.00 76.48 ? 51  ARG A CZ  1 
ATOM   2158 N NH1 . ARG C 3 51  ? 201.730 249.670 167.459 1.00 76.48 ? 51  ARG A NH1 1 
ATOM   2159 N NH2 . ARG C 3 51  ? 203.213 251.097 168.459 1.00 76.48 ? 51  ARG A NH2 1 
ATOM   2160 N N   . ARG C 3 52  ? 197.039 246.417 172.890 1.00 67.89 ? 52  ARG A N   1 
ATOM   2161 C CA  . ARG C 3 52  ? 196.649 245.402 173.859 1.00 67.89 ? 52  ARG A CA  1 
ATOM   2162 C C   . ARG C 3 52  ? 197.646 244.253 173.777 1.00 67.89 ? 52  ARG A C   1 
ATOM   2163 O O   . ARG C 3 52  ? 198.507 244.217 172.895 1.00 67.89 ? 52  ARG A O   1 
ATOM   2164 C CB  . ARG C 3 52  ? 195.217 244.923 173.604 1.00 67.89 ? 52  ARG A CB  1 
ATOM   2165 C CG  . ARG C 3 52  ? 194.226 246.052 173.360 1.00 67.89 ? 52  ARG A CG  1 
ATOM   2166 C CD  . ARG C 3 52  ? 192.992 245.934 174.240 1.00 67.89 ? 52  ARG A CD  1 
ATOM   2167 N NE  . ARG C 3 52  ? 192.278 244.683 174.016 1.00 67.89 ? 52  ARG A NE  1 
ATOM   2168 C CZ  . ARG C 3 52  ? 191.198 244.569 173.256 1.00 67.89 ? 52  ARG A CZ  1 
ATOM   2169 N NH1 . ARG C 3 52  ? 190.682 245.612 172.629 1.00 67.89 ? 52  ARG A NH1 1 
ATOM   2170 N NH2 . ARG C 3 52  ? 190.625 243.377 173.117 1.00 67.89 ? 52  ARG A NH2 1 
ATOM   2171 N N   . VAL C 3 53  ? 197.536 243.302 174.703 1.00 61.56 ? 53  VAL A N   1 
ATOM   2172 C CA  . VAL C 3 53  ? 198.423 242.145 174.742 1.00 61.56 ? 53  VAL A CA  1 
ATOM   2173 C C   . VAL C 3 53  ? 197.582 240.884 174.875 1.00 61.56 ? 53  VAL A C   1 
ATOM   2174 O O   . VAL C 3 53  ? 196.557 240.882 175.564 1.00 61.56 ? 53  VAL A O   1 
ATOM   2175 C CB  . VAL C 3 53  ? 199.459 242.250 175.880 1.00 61.56 ? 53  VAL A CB  1 
ATOM   2176 C CG1 . VAL C 3 53  ? 198.906 241.733 177.195 1.00 61.56 ? 53  VAL A CG1 1 
ATOM   2177 C CG2 . VAL C 3 53  ? 200.730 241.506 175.510 1.00 61.56 ? 53  VAL A CG2 1 
ATOM   2178 N N   . TYR C 3 54  ? 197.994 239.828 174.182 1.00 60.53 ? 54  TYR A N   1 
ATOM   2179 C CA  . TYR C 3 54  ? 197.308 238.548 174.183 1.00 60.53 ? 54  TYR A CA  1 
ATOM   2180 C C   . TYR C 3 54  ? 198.305 237.443 174.499 1.00 60.53 ? 54  TYR A C   1 
ATOM   2181 O O   . TYR C 3 54  ? 199.517 237.623 174.370 1.00 60.53 ? 54  TYR A O   1 
ATOM   2182 C CB  . TYR C 3 54  ? 196.639 238.261 172.831 1.00 60.53 ? 54  TYR A CB  1 
ATOM   2183 C CG  . TYR C 3 54  ? 195.846 239.407 172.246 1.00 60.53 ? 54  TYR A CG  1 
ATOM   2184 C CD1 . TYR C 3 54  ? 196.475 240.442 171.571 1.00 60.53 ? 54  TYR A CD1 1 
ATOM   2185 C CD2 . TYR C 3 54  ? 194.462 239.439 172.348 1.00 60.53 ? 54  TYR A CD2 1 
ATOM   2186 C CE1 . TYR C 3 54  ? 195.752 241.483 171.030 1.00 60.53 ? 54  TYR A CE1 1 
ATOM   2187 C CE2 . TYR C 3 54  ? 193.731 240.477 171.808 1.00 60.53 ? 54  TYR A CE2 1 
ATOM   2188 C CZ  . TYR C 3 54  ? 194.381 241.496 171.151 1.00 60.53 ? 54  TYR A CZ  1 
ATOM   2189 O OH  . TYR C 3 54  ? 193.656 242.534 170.611 1.00 60.53 ? 54  TYR A OH  1 
ATOM   2190 N N   . VAL C 3 55  ? 197.788 236.294 174.926 1.00 53.12 ? 55  VAL A N   1 
ATOM   2191 C CA  . VAL C 3 55  ? 198.605 235.114 175.185 1.00 53.12 ? 55  VAL A CA  1 
ATOM   2192 C C   . VAL C 3 55  ? 198.004 233.950 174.413 1.00 53.12 ? 55  VAL A C   1 
ATOM   2193 O O   . VAL C 3 55  ? 196.789 233.734 174.461 1.00 53.12 ? 55  VAL A O   1 
ATOM   2194 C CB  . VAL C 3 55  ? 198.686 234.789 176.686 1.00 53.12 ? 55  VAL A CB  1 
ATOM   2195 C CG1 . VAL C 3 55  ? 199.512 233.544 176.911 1.00 53.12 ? 55  VAL A CG1 1 
ATOM   2196 C CG2 . VAL C 3 55  ? 199.276 235.955 177.446 1.00 53.12 ? 55  VAL A CG2 1 
ATOM   2197 N N   . THR C 3 56  ? 198.846 233.201 173.704 1.00 52.52 ? 56  THR A N   1 
ATOM   2198 C CA  . THR C 3 56  ? 198.369 232.164 172.800 1.00 52.52 ? 56  THR A CA  1 
ATOM   2199 C C   . THR C 3 56  ? 199.066 230.841 173.083 1.00 52.52 ? 56  THR A C   1 
ATOM   2200 O O   . THR C 3 56  ? 200.220 230.809 173.514 1.00 52.52 ? 56  THR A O   1 
ATOM   2201 C CB  . THR C 3 56  ? 198.598 232.556 171.345 1.00 52.52 ? 56  THR A CB  1 
ATOM   2202 O OG1 . THR C 3 56  ? 198.400 233.966 171.198 1.00 52.52 ? 56  THR A OG1 1 
ATOM   2203 C CG2 . THR C 3 56  ? 197.621 231.828 170.445 1.00 52.52 ? 56  THR A CG2 1 
ATOM   2204 N N   . LEU C 3 57  ? 198.346 229.746 172.840 1.00 51.88 ? 57  LEU A N   1 
ATOM   2205 C CA  . LEU C 3 57  ? 198.874 228.397 172.990 1.00 51.88 ? 57  LEU A CA  1 
ATOM   2206 C C   . LEU C 3 57  ? 198.664 227.650 171.684 1.00 51.88 ? 57  LEU A C   1 
ATOM   2207 O O   . LEU C 3 57  ? 197.562 227.669 171.128 1.00 51.88 ? 57  LEU A O   1 
ATOM   2208 C CB  . LEU C 3 57  ? 198.189 227.647 174.138 1.00 51.88 ? 57  LEU A CB  1 
ATOM   2209 C CG  . LEU C 3 57  ? 199.051 226.699 174.974 1.00 51.88 ? 57  LEU A CG  1 
ATOM   2210 C CD1 . LEU C 3 57  ? 198.255 226.148 176.133 1.00 51.88 ? 57  LEU A CD1 1 
ATOM   2211 C CD2 . LEU C 3 57  ? 199.612 225.566 174.143 1.00 51.88 ? 57  LEU A CD2 1 
ATOM   2212 N N   . THR C 3 58  ? 199.715 226.997 171.198 1.00 55.58 ? 58  THR A N   1 
ATOM   2213 C CA  . THR C 3 58  ? 199.671 226.282 169.932 1.00 55.58 ? 58  THR A CA  1 
ATOM   2214 C C   . THR C 3 58  ? 200.249 224.890 170.112 1.00 55.58 ? 58  THR A C   1 
ATOM   2215 O O   . THR C 3 58  ? 201.368 224.739 170.608 1.00 55.58 ? 58  THR A O   1 
ATOM   2216 C CB  . THR C 3 58  ? 200.448 227.029 168.852 1.00 55.58 ? 58  THR A CB  1 
ATOM   2217 O OG1 . THR C 3 58  ? 199.708 228.185 168.442 1.00 55.58 ? 58  THR A OG1 1 
ATOM   2218 C CG2 . THR C 3 58  ? 200.681 226.135 167.655 1.00 55.58 ? 58  THR A CG2 1 
ATOM   2219 N N   . CYS C 3 59  ? 199.483 223.877 169.709 1.00 60.99 ? 59  CYS A N   1 
ATOM   2220 C CA  . CYS C 3 59  ? 199.936 222.491 169.670 1.00 60.99 ? 59  CYS A CA  1 
ATOM   2221 C C   . CYS C 3 59  ? 199.992 222.073 168.207 1.00 60.99 ? 59  CYS A C   1 
ATOM   2222 O O   . CYS C 3 59  ? 198.953 221.814 167.591 1.00 60.99 ? 59  CYS A O   1 
ATOM   2223 C CB  . CYS C 3 59  ? 199.002 221.588 170.473 1.00 60.99 ? 59  CYS A CB  1 
ATOM   2224 S SG  . CYS C 3 59  ? 199.066 219.837 170.031 1.00 60.99 ? 59  CYS A SG  1 
ATOM   2225 N N   . ALA C 3 60  ? 201.199 222.006 167.651 1.00 63.30 ? 60  ALA A N   1 
ATOM   2226 C CA  . ALA C 3 60  ? 201.375 221.871 166.215 1.00 63.30 ? 60  ALA A CA  1 
ATOM   2227 C C   . ALA C 3 60  ? 202.316 220.722 165.888 1.00 63.30 ? 60  ALA A C   1 
ATOM   2228 O O   . ALA C 3 60  ? 203.132 220.300 166.710 1.00 63.30 ? 60  ALA A O   1 
ATOM   2229 C CB  . ALA C 3 60  ? 201.909 223.169 165.595 1.00 63.30 ? 60  ALA A CB  1 
ATOM   2230 N N   . PHE C 3 61  ? 202.182 220.221 164.664 1.00 67.41 ? 61  PHE A N   1 
ATOM   2231 C CA  . PHE C 3 61  ? 203.055 219.198 164.101 1.00 67.41 ? 61  PHE A CA  1 
ATOM   2232 C C   . PHE C 3 61  ? 203.830 219.842 162.960 1.00 67.41 ? 61  PHE A C   1 
ATOM   2233 O O   . PHE C 3 61  ? 203.240 220.245 161.953 1.00 67.41 ? 61  PHE A O   1 
ATOM   2234 C CB  . PHE C 3 61  ? 202.238 218.002 163.615 1.00 67.41 ? 61  PHE A CB  1 
ATOM   2235 C CG  . PHE C 3 61  ? 203.047 216.755 163.366 1.00 67.41 ? 61  PHE A CG  1 
ATOM   2236 C CD1 . PHE C 3 61  ? 204.432 216.787 163.345 1.00 67.41 ? 61  PHE A CD1 1 
ATOM   2237 C CD2 . PHE C 3 61  ? 202.409 215.543 163.155 1.00 67.41 ? 61  PHE A CD2 1 
ATOM   2238 C CE1 . PHE C 3 61  ? 205.163 215.641 163.117 1.00 67.41 ? 61  PHE A CE1 1 
ATOM   2239 C CE2 . PHE C 3 61  ? 203.135 214.392 162.927 1.00 67.41 ? 61  PHE A CE2 1 
ATOM   2240 C CZ  . PHE C 3 61  ? 204.515 214.441 162.908 1.00 67.41 ? 61  PHE A CZ  1 
ATOM   2241 N N   . ARG C 3 62  ? 205.144 219.936 163.112 1.00 68.05 ? 62  ARG A N   1 
ATOM   2242 C CA  . ARG C 3 62  ? 205.973 220.549 162.085 1.00 68.05 ? 62  ARG A CA  1 
ATOM   2243 C C   . ARG C 3 62  ? 207.270 219.777 161.877 1.00 68.05 ? 62  ARG A C   1 
ATOM   2244 O O   . ARG C 3 62  ? 208.105 220.160 161.058 1.00 68.05 ? 62  ARG A O   1 
ATOM   2245 C CB  . ARG C 3 62  ? 206.280 222.003 162.445 1.00 68.05 ? 62  ARG A CB  1 
ATOM   2246 C CG  . ARG C 3 62  ? 206.768 222.205 163.866 1.00 68.05 ? 62  ARG A CG  1 
ATOM   2247 C CD  . ARG C 3 62  ? 207.091 223.666 164.129 1.00 68.05 ? 62  ARG A CD  1 
ATOM   2248 N NE  . ARG C 3 62  ? 207.210 223.953 165.553 1.00 68.05 ? 62  ARG A NE  1 
ATOM   2249 C CZ  . ARG C 3 62  ? 207.066 225.157 166.089 1.00 68.05 ? 62  ARG A CZ  1 
ATOM   2250 N NH1 . ARG C 3 62  ? 206.801 226.218 165.344 1.00 68.05 ? 62  ARG A NH1 1 
ATOM   2251 N NH2 . ARG C 3 62  ? 207.191 225.301 167.405 1.00 68.05 ? 62  ARG A NH2 1 
ATOM   2252 N N   . THR C 3 74  ? 208.299 224.633 153.911 1.00 77.70 ? 74  THR A N   1 
ATOM   2253 C CA  . THR C 3 74  ? 208.242 223.922 155.182 1.00 77.70 ? 74  THR A CA  1 
ATOM   2254 C C   . THR C 3 74  ? 206.830 223.410 155.454 1.00 77.70 ? 74  THR A C   1 
ATOM   2255 O O   . THR C 3 74  ? 205.854 224.147 155.314 1.00 77.70 ? 74  THR A O   1 
ATOM   2256 C CB  . THR C 3 74  ? 208.692 224.817 156.349 1.00 77.70 ? 74  THR A CB  1 
ATOM   2257 O OG1 . THR C 3 74  ? 207.901 226.012 156.369 1.00 77.70 ? 74  THR A OG1 1 
ATOM   2258 C CG2 . THR C 3 74  ? 210.156 225.193 156.195 1.00 77.70 ? 74  THR A CG2 1 
ATOM   2259 N N   . PHE C 3 75  ? 206.730 222.141 155.842 1.00 72.41 ? 75  PHE A N   1 
ATOM   2260 C CA  . PHE C 3 75  ? 205.442 221.517 156.115 1.00 72.41 ? 75  PHE A CA  1 
ATOM   2261 C C   . PHE C 3 75  ? 205.108 221.667 157.594 1.00 72.41 ? 75  PHE A C   1 
ATOM   2262 O O   . PHE C 3 75  ? 205.852 221.184 158.453 1.00 72.41 ? 75  PHE A O   1 
ATOM   2263 C CB  . PHE C 3 75  ? 205.474 220.045 155.713 1.00 72.41 ? 75  PHE A CB  1 
ATOM   2264 C CG  . PHE C 3 75  ? 204.125 219.385 155.706 1.00 72.41 ? 75  PHE A CG  1 
ATOM   2265 C CD1 . PHE C 3 75  ? 203.331 219.415 154.573 1.00 72.41 ? 75  PHE A CD1 1 
ATOM   2266 C CD2 . PHE C 3 75  ? 203.657 218.725 156.830 1.00 72.41 ? 75  PHE A CD2 1 
ATOM   2267 C CE1 . PHE C 3 75  ? 202.091 218.805 154.562 1.00 72.41 ? 75  PHE A CE1 1 
ATOM   2268 C CE2 . PHE C 3 75  ? 202.419 218.113 156.825 1.00 72.41 ? 75  PHE A CE2 1 
ATOM   2269 C CZ  . PHE C 3 75  ? 201.635 218.153 155.690 1.00 72.41 ? 75  PHE A CZ  1 
ATOM   2270 N N   . ARG C 3 76  ? 203.993 222.330 157.890 1.00 67.75 ? 76  ARG A N   1 
ATOM   2271 C CA  . ARG C 3 76  ? 203.601 222.581 159.270 1.00 67.75 ? 76  ARG A CA  1 
ATOM   2272 C C   . ARG C 3 76  ? 202.085 222.566 159.385 1.00 67.75 ? 76  ARG A C   1 
ATOM   2273 O O   . ARG C 3 76  ? 201.395 223.200 158.583 1.00 67.75 ? 76  ARG A O   1 
ATOM   2274 C CB  . ARG C 3 76  ? 204.154 223.923 159.760 1.00 67.75 ? 76  ARG A CB  1 
ATOM   2275 C CG  . ARG C 3 76  ? 203.342 224.557 160.877 1.00 67.75 ? 76  ARG A CG  1 
ATOM   2276 C CD  . ARG C 3 76  ? 203.595 226.054 160.978 1.00 67.75 ? 76  ARG A CD  1 
ATOM   2277 N NE  . ARG C 3 76  ? 203.020 226.625 162.190 1.00 67.75 ? 76  ARG A NE  1 
ATOM   2278 C CZ  . ARG C 3 76  ? 201.720 226.754 162.417 1.00 67.75 ? 76  ARG A CZ  1 
ATOM   2279 N NH1 . ARG C 3 76  ? 200.820 226.397 161.516 1.00 67.75 ? 76  ARG A NH1 1 
ATOM   2280 N NH2 . ARG C 3 76  ? 201.312 227.262 163.576 1.00 67.75 ? 76  ARG A NH2 1 
ATOM   2281 N N   . LYS C 3 77  ? 201.576 221.839 160.378 1.00 66.74 ? 77  LYS A N   1 
ATOM   2282 C CA  . LYS C 3 77  ? 200.153 221.813 160.678 1.00 66.74 ? 77  LYS A CA  1 
ATOM   2283 C C   . LYS C 3 77  ? 199.957 221.896 162.185 1.00 66.74 ? 77  LYS A C   1 
ATOM   2284 O O   . LYS C 3 77  ? 200.823 221.499 162.966 1.00 66.74 ? 77  LYS A O   1 
ATOM   2285 C CB  . LYS C 3 77  ? 199.467 220.550 160.139 1.00 66.74 ? 77  LYS A CB  1 
ATOM   2286 C CG  . LYS C 3 77  ? 200.127 219.929 158.926 1.00 66.74 ? 77  LYS A CG  1 
ATOM   2287 C CD  . LYS C 3 77  ? 199.302 218.773 158.384 1.00 66.74 ? 77  LYS A CD  1 
ATOM   2288 C CE  . LYS C 3 77  ? 197.828 219.133 158.282 1.00 66.74 ? 77  LYS A CE  1 
ATOM   2289 N NZ  . LYS C 3 77  ? 197.600 220.323 157.415 1.00 66.74 ? 77  LYS A NZ  1 
ATOM   2290 N N   . ASP C 3 78  ? 198.799 222.408 162.585 1.00 64.78 ? 78  ASP A N   1 
ATOM   2291 C CA  . ASP C 3 78  ? 198.439 222.566 163.985 1.00 64.78 ? 78  ASP A CA  1 
ATOM   2292 C C   . ASP C 3 78  ? 197.435 221.496 164.398 1.00 64.78 ? 78  ASP A C   1 
ATOM   2293 O O   . ASP C 3 78  ? 196.864 220.789 163.567 1.00 64.78 ? 78  ASP A O   1 
ATOM   2294 C CB  . ASP C 3 78  ? 197.864 223.963 164.245 1.00 64.78 ? 78  ASP A CB  1 
ATOM   2295 C CG  . ASP C 3 78  ? 198.718 225.066 163.648 1.00 64.78 ? 78  ASP A CG  1 
ATOM   2296 O OD1 . ASP C 3 78  ? 198.792 225.156 162.404 1.00 64.78 ? 78  ASP A OD1 1 
ATOM   2297 O OD2 . ASP C 3 78  ? 199.315 225.843 164.422 1.00 64.78 ? 78  ASP A OD2 1 
ATOM   2298 N N   . LEU C 3 79  ? 197.226 221.381 165.708 1.00 60.83 ? 79  LEU A N   1 
ATOM   2299 C CA  . LEU C 3 79  ? 196.260 220.425 166.234 1.00 60.83 ? 79  LEU A CA  1 
ATOM   2300 C C   . LEU C 3 79  ? 195.327 221.051 167.266 1.00 60.83 ? 79  LEU A C   1 
ATOM   2301 O O   . LEU C 3 79  ? 194.201 220.580 167.448 1.00 60.83 ? 79  LEU A O   1 
ATOM   2302 C CB  . LEU C 3 79  ? 196.976 219.217 166.840 1.00 60.83 ? 79  LEU A CB  1 
ATOM   2303 C CG  . LEU C 3 79  ? 197.828 218.381 165.883 1.00 60.83 ? 79  LEU A CG  1 
ATOM   2304 C CD1 . LEU C 3 79  ? 199.279 218.828 165.890 1.00 60.83 ? 79  LEU A CD1 1 
ATOM   2305 C CD2 . LEU C 3 79  ? 197.720 216.899 166.210 1.00 60.83 ? 79  LEU A CD2 1 
ATOM   2306 N N   . PHE C 3 80  ? 195.772 222.104 167.946 1.00 57.30 ? 80  PHE A N   1 
ATOM   2307 C CA  . PHE C 3 80  ? 194.932 222.760 168.940 1.00 57.30 ? 80  PHE A CA  1 
ATOM   2308 C C   . PHE C 3 80  ? 195.443 224.176 169.162 1.00 57.30 ? 80  PHE A C   1 
ATOM   2309 O O   . PHE C 3 80  ? 196.641 224.442 169.035 1.00 57.30 ? 80  PHE A O   1 
ATOM   2310 C CB  . PHE C 3 80  ? 194.917 221.986 170.259 1.00 57.30 ? 80  PHE A CB  1 
ATOM   2311 C CG  . PHE C 3 80  ? 194.234 222.710 171.371 1.00 57.30 ? 80  PHE A CG  1 
ATOM   2312 C CD1 . PHE C 3 80  ? 192.865 222.880 171.356 1.00 57.30 ? 80  PHE A CD1 1 
ATOM   2313 C CD2 . PHE C 3 80  ? 194.955 223.233 172.422 1.00 57.30 ? 80  PHE A CD2 1 
ATOM   2314 C CE1 . PHE C 3 80  ? 192.226 223.552 172.375 1.00 57.30 ? 80  PHE A CE1 1 
ATOM   2315 C CE2 . PHE C 3 80  ? 194.319 223.908 173.441 1.00 57.30 ? 80  PHE A CE2 1 
ATOM   2316 C CZ  . PHE C 3 80  ? 192.955 224.065 173.419 1.00 57.30 ? 80  PHE A CZ  1 
ATOM   2317 N N   . VAL C 3 81  ? 194.525 225.080 169.493 1.00 53.66 ? 81  VAL A N   1 
ATOM   2318 C CA  . VAL C 3 81  ? 194.859 226.492 169.653 1.00 53.66 ? 81  VAL A CA  1 
ATOM   2319 C C   . VAL C 3 81  ? 193.805 227.142 170.538 1.00 53.66 ? 81  VAL A C   1 
ATOM   2320 O O   . VAL C 3 81  ? 192.626 226.784 170.488 1.00 53.66 ? 81  VAL A O   1 
ATOM   2321 C CB  . VAL C 3 81  ? 194.970 227.195 168.280 1.00 53.66 ? 81  VAL A CB  1 
ATOM   2322 C CG1 . VAL C 3 81  ? 193.640 227.153 167.551 1.00 53.66 ? 81  VAL A CG1 1 
ATOM   2323 C CG2 . VAL C 3 81  ? 195.454 228.626 168.444 1.00 53.66 ? 81  VAL A CG2 1 
ATOM   2324 N N   . ALA C 3 82  ? 194.242 228.095 171.357 1.00 53.79 ? 82  ALA A N   1 
ATOM   2325 C CA  . ALA C 3 82  ? 193.355 228.830 172.245 1.00 53.79 ? 82  ALA A CA  1 
ATOM   2326 C C   . ALA C 3 82  ? 194.021 230.146 172.615 1.00 53.79 ? 82  ALA A C   1 
ATOM   2327 O O   . ALA C 3 82  ? 195.241 230.206 172.789 1.00 53.79 ? 82  ALA A O   1 
ATOM   2328 C CB  . ALA C 3 82  ? 193.023 228.024 173.503 1.00 53.79 ? 82  ALA A CB  1 
ATOM   2329 N N   . ASN C 3 83  ? 193.213 231.196 172.737 1.00 54.28 ? 83  ASN A N   1 
ATOM   2330 C CA  . ASN C 3 83  ? 193.724 232.529 173.008 1.00 54.28 ? 83  ASN A CA  1 
ATOM   2331 C C   . ASN C 3 83  ? 193.020 233.127 174.217 1.00 54.28 ? 83  ASN A C   1 
ATOM   2332 O O   . ASN C 3 83  ? 191.875 232.794 174.527 1.00 54.28 ? 83  ASN A O   1 
ATOM   2333 C CB  . ASN C 3 83  ? 193.568 233.458 171.796 1.00 54.28 ? 83  ASN A CB  1 
ATOM   2334 C CG  . ASN C 3 83  ? 192.163 233.472 171.245 1.00 54.28 ? 83  ASN A CG  1 
ATOM   2335 O OD1 . ASN C 3 83  ? 191.208 233.786 171.952 1.00 54.28 ? 83  ASN A OD1 1 
ATOM   2336 N ND2 . ASN C 3 83  ? 192.027 233.134 169.969 1.00 54.28 ? 83  ASN A ND2 1 
ATOM   2337 N N   . VAL C 3 84  ? 193.738 234.014 174.902 1.00 58.99 ? 84  VAL A N   1 
ATOM   2338 C CA  . VAL C 3 84  ? 193.238 234.719 176.077 1.00 58.99 ? 84  VAL A CA  1 
ATOM   2339 C C   . VAL C 3 84  ? 193.798 236.132 176.045 1.00 58.99 ? 84  VAL A C   1 
ATOM   2340 O O   . VAL C 3 84  ? 194.945 236.348 175.644 1.00 58.99 ? 84  VAL A O   1 
ATOM   2341 C CB  . VAL C 3 84  ? 193.619 233.984 177.382 1.00 58.99 ? 84  VAL A CB  1 
ATOM   2342 C CG1 . VAL C 3 84  ? 193.542 234.912 178.581 1.00 58.99 ? 84  VAL A CG1 1 
ATOM   2343 C CG2 . VAL C 3 84  ? 192.723 232.776 177.599 1.00 58.99 ? 84  VAL A CG2 1 
ATOM   2344 N N   . GLN C 3 85  ? 192.984 237.096 176.455 1.00 64.36 ? 85  GLN A N   1 
ATOM   2345 C CA  . GLN C 3 85  ? 193.361 238.501 176.484 1.00 64.36 ? 85  GLN A CA  1 
ATOM   2346 C C   . GLN C 3 85  ? 193.596 238.932 177.926 1.00 64.36 ? 85  GLN A C   1 
ATOM   2347 O O   . GLN C 3 85  ? 192.748 238.698 178.792 1.00 64.36 ? 85  GLN A O   1 
ATOM   2348 C CB  . GLN C 3 85  ? 192.271 239.350 175.829 1.00 64.36 ? 85  GLN A CB  1 
ATOM   2349 C CG  . GLN C 3 85  ? 192.130 240.748 176.382 1.00 64.36 ? 85  GLN A CG  1 
ATOM   2350 C CD  . GLN C 3 85  ? 191.163 241.585 175.572 1.00 64.36 ? 85  GLN A CD  1 
ATOM   2351 O OE1 . GLN C 3 85  ? 190.771 241.207 174.469 1.00 64.36 ? 85  GLN A OE1 1 
ATOM   2352 N NE2 . GLN C 3 85  ? 190.771 242.728 176.115 1.00 64.36 ? 85  GLN A NE2 1 
ATOM   2353 N N   . SER C 3 86  ? 194.755 239.544 178.183 1.00 66.78 ? 86  SER A N   1 
ATOM   2354 C CA  . SER C 3 86  ? 195.113 239.917 179.549 1.00 66.78 ? 86  SER A CA  1 
ATOM   2355 C C   . SER C 3 86  ? 194.174 240.975 180.109 1.00 66.78 ? 86  SER A C   1 
ATOM   2356 O O   . SER C 3 86  ? 193.599 240.799 181.188 1.00 66.78 ? 86  SER A O   1 
ATOM   2357 C CB  . SER C 3 86  ? 196.544 240.439 179.596 1.00 66.78 ? 86  SER A CB  1 
ATOM   2358 O OG  . SER C 3 86  ? 196.643 241.631 178.834 1.00 66.78 ? 86  SER A OG  1 
ATOM   2359 N N   . PHE C 3 87  ? 194.011 242.082 179.397 1.00 70.85 ? 87  PHE A N   1 
ATOM   2360 C CA  . PHE C 3 87  ? 193.223 243.200 179.886 1.00 70.85 ? 87  PHE A CA  1 
ATOM   2361 C C   . PHE C 3 87  ? 192.399 243.779 178.747 1.00 70.85 ? 87  PHE A C   1 
ATOM   2362 O O   . PHE C 3 87  ? 192.732 243.590 177.572 1.00 70.85 ? 87  PHE A O   1 
ATOM   2363 C CB  . PHE C 3 87  ? 194.122 244.255 180.558 1.00 70.85 ? 87  PHE A CB  1 
ATOM   2364 C CG  . PHE C 3 87  ? 194.980 245.081 179.616 1.00 70.85 ? 87  PHE A CG  1 
ATOM   2365 C CD1 . PHE C 3 87  ? 194.438 245.831 178.579 1.00 70.85 ? 87  PHE A CD1 1 
ATOM   2366 C CD2 . PHE C 3 87  ? 196.349 245.113 179.796 1.00 70.85 ? 87  PHE A CD2 1 
ATOM   2367 C CE1 . PHE C 3 87  ? 195.234 246.568 177.749 1.00 70.85 ? 87  PHE A CE1 1 
ATOM   2368 C CE2 . PHE C 3 87  ? 197.151 245.855 178.965 1.00 70.85 ? 87  PHE A CE2 1 
ATOM   2369 C CZ  . PHE C 3 87  ? 196.590 246.582 177.941 1.00 70.85 ? 87  PHE A CZ  1 
ATOM   2370 N N   . PRO C 3 88  ? 191.303 244.476 179.062 1.00 75.86 ? 88  PRO A N   1 
ATOM   2371 C CA  . PRO C 3 88  ? 190.720 244.656 180.398 1.00 75.86 ? 88  PRO A CA  1 
ATOM   2372 C C   . PRO C 3 88  ? 190.130 243.348 180.902 1.00 75.86 ? 88  PRO A C   1 
ATOM   2373 O O   . PRO C 3 88  ? 189.540 242.583 180.145 1.00 75.86 ? 88  PRO A O   1 
ATOM   2374 C CB  . PRO C 3 88  ? 189.655 245.741 180.173 1.00 75.86 ? 88  PRO A CB  1 
ATOM   2375 C CG  . PRO C 3 88  ? 189.319 245.654 178.713 1.00 75.86 ? 88  PRO A CG  1 
ATOM   2376 C CD  . PRO C 3 88  ? 190.617 245.297 178.051 1.00 75.86 ? 88  PRO A CD  1 
ATOM   2377 N N   . PRO C 3 89  ? 190.283 243.070 182.186 1.00 77.65 ? 89  PRO A N   1 
ATOM   2378 C CA  . PRO C 3 89  ? 189.794 241.799 182.729 1.00 77.65 ? 89  PRO A CA  1 
ATOM   2379 C C   . PRO C 3 89  ? 188.298 241.818 183.001 1.00 77.65 ? 89  PRO A C   1 
ATOM   2380 O O   . PRO C 3 89  ? 187.790 240.985 183.759 1.00 77.65 ? 89  PRO A O   1 
ATOM   2381 C CB  . PRO C 3 89  ? 190.604 241.644 184.019 1.00 77.65 ? 89  PRO A CB  1 
ATOM   2382 C CG  . PRO C 3 89  ? 190.857 243.044 184.451 1.00 77.65 ? 89  PRO A CG  1 
ATOM   2383 C CD  . PRO C 3 89  ? 191.012 243.860 183.192 1.00 77.65 ? 89  PRO A CD  1 
ATOM   2384 N N   . ALA C 3 90  ? 187.590 242.777 182.400 1.00 81.51 ? 90  ALA A N   1 
ATOM   2385 C CA  . ALA C 3 90  ? 186.137 242.875 182.550 1.00 81.51 ? 90  ALA A CA  1 
ATOM   2386 C C   . ALA C 3 90  ? 185.398 241.581 182.227 1.00 81.51 ? 90  ALA A C   1 
ATOM   2387 O O   . ALA C 3 90  ? 184.521 241.189 183.014 1.00 81.51 ? 90  ALA A O   1 
ATOM   2388 C CB  . ALA C 3 90  ? 185.619 244.033 181.686 1.00 81.51 ? 90  ALA A CB  1 
ATOM   2389 N N   . PRO C 3 91  ? 185.679 240.872 181.120 1.00 82.13 ? 91  PRO A N   1 
ATOM   2390 C CA  . PRO C 3 91  ? 185.057 239.545 180.984 1.00 82.13 ? 91  PRO A CA  1 
ATOM   2391 C C   . PRO C 3 91  ? 185.899 238.483 181.678 1.00 82.13 ? 91  PRO A C   1 
ATOM   2392 O O   . PRO C 3 91  ? 186.550 237.632 181.063 1.00 82.13 ? 91  PRO A O   1 
ATOM   2393 C CB  . PRO C 3 91  ? 184.989 239.370 179.463 1.00 82.13 ? 91  PRO A CB  1 
ATOM   2394 C CG  . PRO C 3 91  ? 186.065 240.304 178.898 1.00 82.13 ? 91  PRO A CG  1 
ATOM   2395 C CD  . PRO C 3 91  ? 186.657 241.087 180.042 1.00 82.13 ? 91  PRO A CD  1 
ATOM   2396 N N   . GLU C 3 92  ? 185.881 238.532 183.010 1.00 83.68 ? 92  GLU A N   1 
ATOM   2397 C CA  . GLU C 3 92  ? 186.786 237.736 183.826 1.00 83.68 ? 92  GLU A CA  1 
ATOM   2398 C C   . GLU C 3 92  ? 186.393 236.266 183.825 1.00 83.68 ? 92  GLU A C   1 
ATOM   2399 O O   . GLU C 3 92  ? 185.863 235.754 184.817 1.00 83.68 ? 92  GLU A O   1 
ATOM   2400 C CB  . GLU C 3 92  ? 186.820 238.278 185.256 1.00 83.68 ? 92  GLU A CB  1 
ATOM   2401 C CG  . GLU C 3 92  ? 185.501 238.866 185.721 1.00 83.68 ? 92  GLU A CG  1 
ATOM   2402 C CD  . GLU C 3 92  ? 185.486 239.166 187.208 1.00 83.68 ? 92  GLU A CD  1 
ATOM   2403 O OE1 . GLU C 3 92  ? 186.571 239.163 187.828 1.00 83.68 ? 92  GLU A OE1 1 
ATOM   2404 O OE2 . GLU C 3 92  ? 184.390 239.404 187.757 1.00 83.68 ? 92  GLU A OE2 1 
ATOM   2405 N N   . ASP C 3 93  ? 186.644 235.586 182.710 1.00 83.99 ? 93  ASP A N   1 
ATOM   2406 C CA  . ASP C 3 93  ? 186.462 234.144 182.654 1.00 83.99 ? 93  ASP A CA  1 
ATOM   2407 C C   . ASP C 3 93  ? 187.519 233.449 183.503 1.00 83.99 ? 93  ASP A C   1 
ATOM   2408 O O   . ASP C 3 93  ? 188.615 233.973 183.722 1.00 83.99 ? 93  ASP A O   1 
ATOM   2409 C CB  . ASP C 3 93  ? 186.537 233.651 181.209 1.00 83.99 ? 93  ASP A CB  1 
ATOM   2410 N N   . LYS C 3 94  ? 187.185 232.243 183.966 1.00 79.98 ? 94  LYS A N   1 
ATOM   2411 C CA  . LYS C 3 94  ? 188.006 231.504 184.927 1.00 79.98 ? 94  LYS A CA  1 
ATOM   2412 C C   . LYS C 3 94  ? 188.396 232.397 186.103 1.00 79.98 ? 94  LYS A C   1 
ATOM   2413 O O   . LYS C 3 94  ? 189.556 232.455 186.516 1.00 79.98 ? 94  LYS A O   1 
ATOM   2414 C CB  . LYS C 3 94  ? 189.245 230.886 184.265 1.00 79.98 ? 94  LYS A CB  1 
ATOM   2415 C CG  . LYS C 3 94  ? 188.969 229.876 183.159 1.00 79.98 ? 94  LYS A CG  1 
ATOM   2416 C CD  . LYS C 3 94  ? 188.249 228.650 183.697 1.00 79.98 ? 94  LYS A CD  1 
ATOM   2417 C CE  . LYS C 3 94  ? 188.039 227.611 182.607 1.00 79.98 ? 94  LYS A CE  1 
ATOM   2418 N NZ  . LYS C 3 94  ? 187.314 226.413 183.111 1.00 79.98 ? 94  LYS A NZ  1 
ATOM   2419 N N   . LYS C 3 95  ? 187.404 233.102 186.642 1.00 82.25 ? 95  LYS A N   1 
ATOM   2420 C CA  . LYS C 3 95  ? 187.619 234.056 187.724 1.00 82.25 ? 95  LYS A CA  1 
ATOM   2421 C C   . LYS C 3 95  ? 188.173 233.433 189.008 1.00 82.25 ? 95  LYS A C   1 
ATOM   2422 O O   . LYS C 3 95  ? 188.823 234.149 189.780 1.00 82.25 ? 95  LYS A O   1 
ATOM   2423 C CB  . LYS C 3 95  ? 186.325 234.827 188.019 1.00 82.25 ? 95  LYS A CB  1 
ATOM   2424 C CG  . LYS C 3 95  ? 185.093 233.983 188.299 1.00 82.25 ? 95  LYS A CG  1 
ATOM   2425 C CD  . LYS C 3 95  ? 183.849 234.850 188.418 1.00 82.25 ? 95  LYS A CD  1 
ATOM   2426 C CE  . LYS C 3 95  ? 182.617 234.012 188.718 1.00 82.25 ? 95  LYS A CE  1 
ATOM   2427 N NZ  . LYS C 3 95  ? 182.585 233.561 190.137 1.00 82.25 ? 95  LYS A NZ  1 
ATOM   2428 N N   . PRO C 3 96  ? 187.957 232.130 189.307 1.00 79.62 ? 96  PRO A N   1 
ATOM   2429 C CA  . PRO C 3 96  ? 188.704 231.544 190.426 1.00 79.62 ? 96  PRO A CA  1 
ATOM   2430 C C   . PRO C 3 96  ? 190.185 231.443 190.109 1.00 79.62 ? 96  PRO A C   1 
ATOM   2431 O O   . PRO C 3 96  ? 190.591 230.651 189.254 1.00 79.62 ? 96  PRO A O   1 
ATOM   2432 C CB  . PRO C 3 96  ? 188.067 230.159 190.599 1.00 79.62 ? 96  PRO A CB  1 
ATOM   2433 C CG  . PRO C 3 96  ? 187.443 229.867 189.293 1.00 79.62 ? 96  PRO A CG  1 
ATOM   2434 C CD  . PRO C 3 96  ? 186.930 231.186 188.827 1.00 79.62 ? 96  PRO A CD  1 
ATOM   2435 N N   . LEU C 3 97  ? 190.999 232.243 190.788 1.00 75.76 ? 97  LEU A N   1 
ATOM   2436 C CA  . LEU C 3 97  ? 192.433 232.262 190.548 1.00 75.76 ? 97  LEU A CA  1 
ATOM   2437 C C   . LEU C 3 97  ? 193.116 231.261 191.466 1.00 75.76 ? 97  LEU A C   1 
ATOM   2438 O O   . LEU C 3 97  ? 192.862 231.245 192.675 1.00 75.76 ? 97  LEU A O   1 
ATOM   2439 C CB  . LEU C 3 97  ? 193.002 233.663 190.771 1.00 75.76 ? 97  LEU A CB  1 
ATOM   2440 C CG  . LEU C 3 97  ? 193.215 234.514 189.517 1.00 75.76 ? 97  LEU A CG  1 
ATOM   2441 C CD1 . LEU C 3 97  ? 191.943 234.577 188.687 1.00 75.76 ? 97  LEU A CD1 1 
ATOM   2442 C CD2 . LEU C 3 97  ? 193.676 235.910 189.886 1.00 75.76 ? 97  LEU A CD2 1 
ATOM   2443 N N   . THR C 3 98  ? 193.978 230.427 190.889 1.00 76.82 ? 98  THR A N   1 
ATOM   2444 C CA  . THR C 3 98  ? 194.740 229.480 191.686 1.00 76.82 ? 98  THR A CA  1 
ATOM   2445 C C   . THR C 3 98  ? 195.679 230.228 192.626 1.00 76.82 ? 98  THR A C   1 
ATOM   2446 O O   . THR C 3 98  ? 196.000 231.402 192.423 1.00 76.82 ? 98  THR A O   1 
ATOM   2447 C CB  . THR C 3 98  ? 195.535 228.534 190.789 1.00 76.82 ? 98  THR A CB  1 
ATOM   2448 O OG1 . THR C 3 98  ? 196.627 229.243 190.190 1.00 76.82 ? 98  THR A OG1 1 
ATOM   2449 C CG2 . THR C 3 98  ? 194.644 227.963 189.697 1.00 76.82 ? 98  THR A CG2 1 
ATOM   2450 N N   . ARG C 3 99  ? 196.115 229.526 193.675 1.00 77.29 ? 99  ARG A N   1 
ATOM   2451 C CA  . ARG C 3 99  ? 196.884 230.177 194.731 1.00 77.29 ? 99  ARG A CA  1 
ATOM   2452 C C   . ARG C 3 99  ? 198.140 230.838 194.181 1.00 77.29 ? 99  ARG A C   1 
ATOM   2453 O O   . ARG C 3 99  ? 198.369 232.032 194.411 1.00 77.29 ? 99  ARG A O   1 
ATOM   2454 C CB  . ARG C 3 99  ? 197.244 229.163 195.817 1.00 77.29 ? 99  ARG A CB  1 
ATOM   2455 N N   . LEU C 3 100 ? 198.942 230.089 193.420 1.00 76.02 ? 100 LEU A N   1 
ATOM   2456 C CA  . LEU C 3 100 ? 200.212 230.617 192.932 1.00 76.02 ? 100 LEU A CA  1 
ATOM   2457 C C   . LEU C 3 100 ? 200.005 231.873 192.100 1.00 76.02 ? 100 LEU A C   1 
ATOM   2458 O O   . LEU C 3 100 ? 200.811 232.808 192.165 1.00 76.02 ? 100 LEU A O   1 
ATOM   2459 C CB  . LEU C 3 100 ? 200.946 229.551 192.120 1.00 76.02 ? 100 LEU A CB  1 
ATOM   2460 C CG  . LEU C 3 100 ? 202.245 229.978 191.433 1.00 76.02 ? 100 LEU A CG  1 
ATOM   2461 C CD1 . LEU C 3 100 ? 203.238 230.525 192.444 1.00 76.02 ? 100 LEU A CD1 1 
ATOM   2462 C CD2 . LEU C 3 100 ? 202.849 228.815 190.659 1.00 76.02 ? 100 LEU A CD2 1 
ATOM   2463 N N   . GLN C 3 101 ? 198.929 231.916 191.315 1.00 73.92 ? 101 GLN A N   1 
ATOM   2464 C CA  . GLN C 3 101 ? 198.645 233.105 190.520 1.00 73.92 ? 101 GLN A CA  1 
ATOM   2465 C C   . GLN C 3 101 ? 198.431 234.319 191.413 1.00 73.92 ? 101 GLN A C   1 
ATOM   2466 O O   . GLN C 3 101 ? 198.996 235.394 191.170 1.00 73.92 ? 101 GLN A O   1 
ATOM   2467 C CB  . GLN C 3 101 ? 197.419 232.860 189.643 1.00 73.92 ? 101 GLN A CB  1 
ATOM   2468 C CG  . GLN C 3 101 ? 197.660 231.909 188.496 1.00 73.92 ? 101 GLN A CG  1 
ATOM   2469 C CD  . GLN C 3 101 ? 196.392 231.588 187.743 1.00 73.92 ? 101 GLN A CD  1 
ATOM   2470 O OE1 . GLN C 3 101 ? 195.590 230.767 188.180 1.00 73.92 ? 101 GLN A OE1 1 
ATOM   2471 N NE2 . GLN C 3 101 ? 196.198 232.243 186.606 1.00 73.92 ? 101 GLN A NE2 1 
ATOM   2472 N N   . GLU C 3 102 ? 197.624 234.159 192.463 1.00 77.68 ? 102 GLU A N   1 
ATOM   2473 C CA  . GLU C 3 102 ? 197.365 235.272 193.369 1.00 77.68 ? 102 GLU A CA  1 
ATOM   2474 C C   . GLU C 3 102 ? 198.635 235.711 194.082 1.00 77.68 ? 102 GLU A C   1 
ATOM   2475 O O   . GLU C 3 102 ? 198.895 236.912 194.213 1.00 77.68 ? 102 GLU A O   1 
ATOM   2476 C CB  . GLU C 3 102 ? 196.287 234.885 194.382 1.00 77.68 ? 102 GLU A CB  1 
ATOM   2477 C CG  . GLU C 3 102 ? 194.946 234.533 193.759 1.00 77.68 ? 102 GLU A CG  1 
ATOM   2478 C CD  . GLU C 3 102 ? 193.867 234.295 194.797 1.00 77.68 ? 102 GLU A CD  1 
ATOM   2479 O OE1 . GLU C 3 102 ? 194.138 233.584 195.787 1.00 77.68 ? 102 GLU A OE1 1 
ATOM   2480 O OE2 . GLU C 3 102 ? 192.747 234.820 194.622 1.00 77.68 ? 102 GLU A OE2 1 
ATOM   2481 N N   . ARG C 3 103 ? 199.438 234.754 194.558 1.00 76.52 ? 103 ARG A N   1 
ATOM   2482 C CA  . ARG C 3 103 ? 200.669 235.123 195.250 1.00 76.52 ? 103 ARG A CA  1 
ATOM   2483 C C   . ARG C 3 103 ? 201.632 235.845 194.319 1.00 76.52 ? 103 ARG A C   1 
ATOM   2484 O O   . ARG C 3 103 ? 202.276 236.819 194.721 1.00 76.52 ? 103 ARG A O   1 
ATOM   2485 C CB  . ARG C 3 103 ? 201.342 233.898 195.870 1.00 76.52 ? 103 ARG A CB  1 
ATOM   2486 C CG  . ARG C 3 103 ? 200.394 232.867 196.434 1.00 76.52 ? 103 ARG A CG  1 
ATOM   2487 C CD  . ARG C 3 103 ? 201.078 231.996 197.473 1.00 76.52 ? 103 ARG A CD  1 
ATOM   2488 N NE  . ARG C 3 103 ? 202.515 231.897 197.246 1.00 76.52 ? 103 ARG A NE  1 
ATOM   2489 C CZ  . ARG C 3 103 ? 203.438 232.254 198.128 1.00 76.52 ? 103 ARG A CZ  1 
ATOM   2490 N NH1 . ARG C 3 103 ? 203.110 232.743 199.313 1.00 76.52 ? 103 ARG A NH1 1 
ATOM   2491 N NH2 . ARG C 3 103 ? 204.723 232.117 197.814 1.00 76.52 ? 103 ARG A NH2 1 
ATOM   2492 N N   . LEU C 3 104 ? 201.750 235.384 193.074 1.00 74.30 ? 104 LEU A N   1 
ATOM   2493 C CA  . LEU C 3 104 ? 202.641 236.050 192.134 1.00 74.30 ? 104 LEU A CA  1 
ATOM   2494 C C   . LEU C 3 104 ? 202.155 237.460 191.823 1.00 74.30 ? 104 LEU A C   1 
ATOM   2495 O O   . LEU C 3 104 ? 202.953 238.402 191.755 1.00 74.30 ? 104 LEU A O   1 
ATOM   2496 C CB  . LEU C 3 104 ? 202.773 235.221 190.856 1.00 74.30 ? 104 LEU A CB  1 
ATOM   2497 C CG  . LEU C 3 104 ? 203.955 234.247 190.834 1.00 74.30 ? 104 LEU A CG  1 
ATOM   2498 C CD1 . LEU C 3 104 ? 203.767 233.186 189.762 1.00 74.30 ? 104 LEU A CD1 1 
ATOM   2499 C CD2 . LEU C 3 104 ? 205.265 234.997 190.632 1.00 74.30 ? 104 LEU A CD2 1 
ATOM   2500 N N   . ILE C 3 105 ? 200.845 237.627 191.633 1.00 73.05 ? 105 ILE A N   1 
ATOM   2501 C CA  . ILE C 3 105 ? 200.316 238.952 191.324 1.00 73.05 ? 105 ILE A CA  1 
ATOM   2502 C C   . ILE C 3 105 ? 200.515 239.896 192.502 1.00 73.05 ? 105 ILE A C   1 
ATOM   2503 O O   . ILE C 3 105 ? 200.937 241.046 192.330 1.00 73.05 ? 105 ILE A O   1 
ATOM   2504 C CB  . ILE C 3 105 ? 198.835 238.859 190.914 1.00 73.05 ? 105 ILE A CB  1 
ATOM   2505 C CG1 . ILE C 3 105 ? 198.701 238.165 189.558 1.00 73.05 ? 105 ILE A CG1 1 
ATOM   2506 C CG2 . ILE C 3 105 ? 198.205 240.242 190.864 1.00 73.05 ? 105 ILE A CG2 1 
ATOM   2507 C CD1 . ILE C 3 105 ? 197.324 237.597 189.300 1.00 73.05 ? 105 ILE A CD1 1 
ATOM   2508 N N   . LYS C 3 106 ? 200.225 239.427 193.717 1.00 75.52 ? 106 LYS A N   1 
ATOM   2509 C CA  . LYS C 3 106 ? 200.325 240.296 194.886 1.00 75.52 ? 106 LYS A CA  1 
ATOM   2510 C C   . LYS C 3 106 ? 201.773 240.609 195.240 1.00 75.52 ? 106 LYS A C   1 
ATOM   2511 O O   . LYS C 3 106 ? 202.071 241.723 195.686 1.00 75.52 ? 106 LYS A O   1 
ATOM   2512 C CB  . LYS C 3 106 ? 199.616 239.655 196.078 1.00 75.52 ? 106 LYS A CB  1 
ATOM   2513 N N   . LYS C 3 107 ? 202.680 239.647 195.057 1.00 72.79 ? 107 LYS A N   1 
ATOM   2514 C CA  . LYS C 3 107 ? 204.088 239.882 195.353 1.00 72.79 ? 107 LYS A CA  1 
ATOM   2515 C C   . LYS C 3 107 ? 204.661 240.971 194.461 1.00 72.79 ? 107 LYS A C   1 
ATOM   2516 O O   . LYS C 3 107 ? 205.410 241.838 194.925 1.00 72.79 ? 107 LYS A O   1 
ATOM   2517 C CB  . LYS C 3 107 ? 204.882 238.585 195.192 1.00 72.79 ? 107 LYS A CB  1 
ATOM   2518 C CG  . LYS C 3 107 ? 206.298 238.643 195.750 1.00 72.79 ? 107 LYS A CG  1 
ATOM   2519 C CD  . LYS C 3 107 ? 207.308 238.924 194.644 1.00 72.79 ? 107 LYS A CD  1 
ATOM   2520 C CE  . LYS C 3 107 ? 208.709 239.116 195.193 1.00 72.79 ? 107 LYS A CE  1 
ATOM   2521 N NZ  . LYS C 3 107 ? 209.540 239.938 194.275 1.00 72.79 ? 107 LYS A NZ  1 
ATOM   2522 N N   . LEU C 3 108 ? 204.323 240.944 193.180 1.00 69.76 ? 108 LEU A N   1 
ATOM   2523 C CA  . LEU C 3 108 ? 204.898 241.879 192.230 1.00 69.76 ? 108 LEU A CA  1 
ATOM   2524 C C   . LEU C 3 108 ? 203.970 243.092 192.140 1.00 69.76 ? 108 LEU A C   1 
ATOM   2525 O O   . LEU C 3 108 ? 202.973 243.185 192.860 1.00 69.76 ? 108 LEU A O   1 
ATOM   2526 C CB  . LEU C 3 108 ? 205.132 241.161 190.900 1.00 69.76 ? 108 LEU A CB  1 
ATOM   2527 C CG  . LEU C 3 108 ? 205.916 241.816 189.765 1.00 69.76 ? 108 LEU A CG  1 
ATOM   2528 C CD1 . LEU C 3 108 ? 206.981 242.754 190.309 1.00 69.76 ? 108 LEU A CD1 1 
ATOM   2529 C CD2 . LEU C 3 108 ? 206.550 240.736 188.909 1.00 69.76 ? 108 LEU A CD2 1 
ATOM   2530 N N   . GLY C 3 109 ? 204.281 244.035 191.255 1.00 69.22 ? 109 GLY A N   1 
ATOM   2531 C CA  . GLY C 3 109 ? 203.544 245.281 191.163 1.00 69.22 ? 109 GLY A CA  1 
ATOM   2532 C C   . GLY C 3 109 ? 202.089 245.135 190.771 1.00 69.22 ? 109 GLY A C   1 
ATOM   2533 O O   . GLY C 3 109 ? 201.573 244.019 190.662 1.00 69.22 ? 109 GLY A O   1 
ATOM   2534 N N   . GLU C 3 110 ? 201.414 246.258 190.556 1.00 70.61 ? 110 GLU A N   1 
ATOM   2535 C CA  . GLU C 3 110 ? 199.989 246.253 190.260 1.00 70.61 ? 110 GLU A CA  1 
ATOM   2536 C C   . GLU C 3 110 ? 199.682 246.070 188.780 1.00 70.61 ? 110 GLU A C   1 
ATOM   2537 O O   . GLU C 3 110 ? 198.505 246.013 188.411 1.00 70.61 ? 110 GLU A O   1 
ATOM   2538 C CB  . GLU C 3 110 ? 199.341 247.548 190.762 1.00 70.61 ? 110 GLU A CB  1 
ATOM   2539 C CG  . GLU C 3 110 ? 199.720 248.785 189.969 1.00 70.61 ? 110 GLU A CG  1 
ATOM   2540 C CD  . GLU C 3 110 ? 199.347 250.069 190.683 1.00 70.61 ? 110 GLU A CD  1 
ATOM   2541 O OE1 . GLU C 3 110 ? 198.319 250.078 191.392 1.00 70.61 ? 110 GLU A OE1 1 
ATOM   2542 O OE2 . GLU C 3 110 ? 200.081 251.069 190.536 1.00 70.61 ? 110 GLU A OE2 1 
ATOM   2543 N N   . HIS C 3 111 ? 200.698 245.975 187.926 1.00 64.80 ? 111 HIS A N   1 
ATOM   2544 C CA  . HIS C 3 111 ? 200.489 245.834 186.492 1.00 64.80 ? 111 HIS A CA  1 
ATOM   2545 C C   . HIS C 3 111 ? 200.553 244.388 186.012 1.00 64.80 ? 111 HIS A C   1 
ATOM   2546 O O   . HIS C 3 111 ? 200.449 244.145 184.807 1.00 64.80 ? 111 HIS A O   1 
ATOM   2547 C CB  . HIS C 3 111 ? 201.509 246.683 185.734 1.00 64.80 ? 111 HIS A CB  1 
ATOM   2548 C CG  . HIS C 3 111 ? 201.586 248.097 186.217 1.00 64.80 ? 111 HIS A CG  1 
ATOM   2549 N ND1 . HIS C 3 111 ? 200.471 248.892 186.366 1.00 64.80 ? 111 HIS A ND1 1 
ATOM   2550 C CD2 . HIS C 3 111 ? 202.643 248.860 186.579 1.00 64.80 ? 111 HIS A CD2 1 
ATOM   2551 C CE1 . HIS C 3 111 ? 200.837 250.083 186.802 1.00 64.80 ? 111 HIS A CE1 1 
ATOM   2552 N NE2 . HIS C 3 111 ? 202.150 250.091 186.938 1.00 64.80 ? 111 HIS A NE2 1 
ATOM   2553 N N   . ALA C 3 112 ? 200.721 243.428 186.915 1.00 64.90 ? 112 ALA A N   1 
ATOM   2554 C CA  . ALA C 3 112 ? 200.680 242.024 186.537 1.00 64.90 ? 112 ALA A CA  1 
ATOM   2555 C C   . ALA C 3 112 ? 199.239 241.544 186.473 1.00 64.90 ? 112 ALA A C   1 
ATOM   2556 O O   . ALA C 3 112 ? 198.416 241.889 187.324 1.00 64.90 ? 112 ALA A O   1 
ATOM   2557 C CB  . ALA C 3 112 ? 201.473 241.176 187.531 1.00 64.90 ? 112 ALA A CB  1 
ATOM   2558 N N   . TYR C 3 113 ? 198.937 240.740 185.460 1.00 59.42 ? 113 TYR A N   1 
ATOM   2559 C CA  . TYR C 3 113 ? 197.591 240.249 185.241 1.00 59.42 ? 113 TYR A CA  1 
ATOM   2560 C C   . TYR C 3 113 ? 197.609 238.751 184.993 1.00 59.42 ? 113 TYR A C   1 
ATOM   2561 O O   . TYR C 3 113 ? 198.599 238.213 184.493 1.00 59.42 ? 113 TYR A O   1 
ATOM   2562 C CB  . TYR C 3 113 ? 196.948 240.964 184.051 1.00 59.42 ? 113 TYR A CB  1 
ATOM   2563 C CG  . TYR C 3 113 ? 196.796 242.442 184.282 1.00 59.42 ? 113 TYR A CG  1 
ATOM   2564 C CD1 . TYR C 3 113 ? 195.827 242.929 185.142 1.00 59.42 ? 113 TYR A CD1 1 
ATOM   2565 C CD2 . TYR C 3 113 ? 197.631 243.348 183.658 1.00 59.42 ? 113 TYR A CD2 1 
ATOM   2566 C CE1 . TYR C 3 113 ? 195.682 244.278 185.359 1.00 59.42 ? 113 TYR A CE1 1 
ATOM   2567 C CE2 . TYR C 3 113 ? 197.494 244.701 183.868 1.00 59.42 ? 113 TYR A CE2 1 
ATOM   2568 C CZ  . TYR C 3 113 ? 196.518 245.160 184.722 1.00 59.42 ? 113 TYR A CZ  1 
ATOM   2569 O OH  . TYR C 3 113 ? 196.374 246.510 184.943 1.00 59.42 ? 113 TYR A OH  1 
ATOM   2570 N N   . PRO C 3 114 ? 196.531 238.053 185.331 1.00 60.32 ? 114 PRO A N   1 
ATOM   2571 C CA  . PRO C 3 114 ? 196.522 236.594 185.227 1.00 60.32 ? 114 PRO A CA  1 
ATOM   2572 C C   . PRO C 3 114 ? 195.961 236.086 183.907 1.00 60.32 ? 114 PRO A C   1 
ATOM   2573 O O   . PRO C 3 114 ? 195.314 236.805 183.144 1.00 60.32 ? 114 PRO A O   1 
ATOM   2574 C CB  . PRO C 3 114 ? 195.612 236.182 186.389 1.00 60.32 ? 114 PRO A CB  1 
ATOM   2575 C CG  . PRO C 3 114 ? 194.620 237.290 186.462 1.00 60.32 ? 114 PRO A CG  1 
ATOM   2576 C CD  . PRO C 3 114 ? 195.336 238.555 186.031 1.00 60.32 ? 114 PRO A CD  1 
ATOM   2577 N N   . PHE C 3 115 ? 196.229 234.809 183.655 1.00 60.50 ? 115 PHE A N   1 
ATOM   2578 C CA  . PHE C 3 115 ? 195.604 234.081 182.560 1.00 60.50 ? 115 PHE A CA  1 
ATOM   2579 C C   . PHE C 3 115 ? 195.718 232.596 182.872 1.00 60.50 ? 115 PHE A C   1 
ATOM   2580 O O   . PHE C 3 115 ? 196.488 232.185 183.741 1.00 60.50 ? 115 PHE A O   1 
ATOM   2581 C CB  . PHE C 3 115 ? 196.233 234.439 181.205 1.00 60.50 ? 115 PHE A CB  1 
ATOM   2582 C CG  . PHE C 3 115 ? 197.619 233.897 181.006 1.00 60.50 ? 115 PHE A CG  1 
ATOM   2583 C CD1 . PHE C 3 115 ? 197.816 232.663 180.419 1.00 60.50 ? 115 PHE A CD1 1 
ATOM   2584 C CD2 . PHE C 3 115 ? 198.724 234.631 181.392 1.00 60.50 ? 115 PHE A CD2 1 
ATOM   2585 C CE1 . PHE C 3 115 ? 199.085 232.165 180.233 1.00 60.50 ? 115 PHE A CE1 1 
ATOM   2586 C CE2 . PHE C 3 115 ? 199.998 234.135 181.204 1.00 60.50 ? 115 PHE A CE2 1 
ATOM   2587 C CZ  . PHE C 3 115 ? 200.176 232.900 180.621 1.00 60.50 ? 115 PHE A CZ  1 
ATOM   2588 N N   . THR C 3 116 ? 194.925 231.794 182.165 1.00 63.17 ? 116 THR A N   1 
ATOM   2589 C CA  . THR C 3 116 ? 194.918 230.355 182.384 1.00 63.17 ? 116 THR A CA  1 
ATOM   2590 C C   . THR C 3 116 ? 194.526 229.648 181.095 1.00 63.17 ? 116 THR A C   1 
ATOM   2591 O O   . THR C 3 116 ? 193.675 230.138 180.349 1.00 63.17 ? 116 THR A O   1 
ATOM   2592 C CB  . THR C 3 116 ? 193.952 229.972 183.513 1.00 63.17 ? 116 THR A CB  1 
ATOM   2593 O OG1 . THR C 3 116 ? 194.287 230.700 184.701 1.00 63.17 ? 116 THR A OG1 1 
ATOM   2594 C CG2 . THR C 3 116 ? 194.026 228.480 183.812 1.00 63.17 ? 116 THR A CG2 1 
ATOM   2595 N N   . PHE C 3 117 ? 195.148 228.499 180.843 1.00 61.45 ? 117 PHE A N   1 
ATOM   2596 C CA  . PHE C 3 117 ? 194.828 227.647 179.706 1.00 61.45 ? 117 PHE A CA  1 
ATOM   2597 C C   . PHE C 3 117 ? 194.439 226.258 180.191 1.00 61.45 ? 117 PHE A C   1 
ATOM   2598 O O   . PHE C 3 117 ? 195.002 225.748 181.164 1.00 61.45 ? 117 PHE A O   1 
ATOM   2599 C CB  . PHE C 3 117 ? 196.008 227.522 178.739 1.00 61.45 ? 117 PHE A CB  1 
ATOM   2600 C CG  . PHE C 3 117 ? 196.294 228.762 177.956 1.00 61.45 ? 117 PHE A CG  1 
ATOM   2601 C CD1 . PHE C 3 117 ? 195.428 229.188 176.968 1.00 61.45 ? 117 PHE A CD1 1 
ATOM   2602 C CD2 . PHE C 3 117 ? 197.445 229.484 178.184 1.00 61.45 ? 117 PHE A CD2 1 
ATOM   2603 C CE1 . PHE C 3 117 ? 195.693 230.320 176.242 1.00 61.45 ? 117 PHE A CE1 1 
ATOM   2604 C CE2 . PHE C 3 117 ? 197.716 230.616 177.457 1.00 61.45 ? 117 PHE A CE2 1 
ATOM   2605 C CZ  . PHE C 3 117 ? 196.838 231.037 176.485 1.00 61.45 ? 117 PHE A CZ  1 
ATOM   2606 N N   . GLU C 3 118 ? 193.473 225.648 179.508 1.00 69.35 ? 118 GLU A N   1 
ATOM   2607 C CA  . GLU C 3 118 ? 193.107 224.255 179.723 1.00 69.35 ? 118 GLU A CA  1 
ATOM   2608 C C   . GLU C 3 118 ? 193.080 223.545 178.377 1.00 69.35 ? 118 GLU A C   1 
ATOM   2609 O O   . GLU C 3 118 ? 192.614 224.109 177.382 1.00 69.35 ? 118 GLU A O   1 
ATOM   2610 C CB  . GLU C 3 118 ? 191.752 224.129 180.426 1.00 69.35 ? 118 GLU A CB  1 
ATOM   2611 C CG  . GLU C 3 118 ? 190.618 224.874 179.746 1.00 69.35 ? 118 GLU A CG  1 
ATOM   2612 C CD  . GLU C 3 118 ? 189.331 224.824 180.547 1.00 69.35 ? 118 GLU A CD  1 
ATOM   2613 O OE1 . GLU C 3 118 ? 189.226 223.968 181.450 1.00 69.35 ? 118 GLU A OE1 1 
ATOM   2614 O OE2 . GLU C 3 118 ? 188.425 225.639 180.273 1.00 69.35 ? 118 GLU A OE2 1 
ATOM   2615 N N   . ILE C 3 119 ? 193.582 222.314 178.342 1.00 67.30 ? 119 ILE A N   1 
ATOM   2616 C CA  . ILE C 3 119 ? 193.833 221.655 177.062 1.00 67.30 ? 119 ILE A CA  1 
ATOM   2617 C C   . ILE C 3 119 ? 193.232 220.254 177.029 1.00 67.30 ? 119 ILE A C   1 
ATOM   2618 O O   . ILE C 3 119 ? 193.216 219.558 178.055 1.00 67.30 ? 119 ILE A O   1 
ATOM   2619 C CB  . ILE C 3 119 ? 195.339 221.596 176.771 1.00 67.30 ? 119 ILE A CB  1 
ATOM   2620 C CG1 . ILE C 3 119 ? 196.107 221.179 178.019 1.00 67.30 ? 119 ILE A CG1 1 
ATOM   2621 C CG2 . ILE C 3 119 ? 195.847 222.948 176.322 1.00 67.30 ? 119 ILE A CG2 1 
ATOM   2622 C CD1 . ILE C 3 119 ? 197.405 220.476 177.709 1.00 67.30 ? 119 ILE A CD1 1 
ATOM   2623 N N   . PRO C 3 120 ? 192.732 219.806 175.881 1.00 67.77 ? 120 PRO A N   1 
ATOM   2624 C CA  . PRO C 3 120 ? 192.337 218.404 175.725 1.00 67.77 ? 120 PRO A CA  1 
ATOM   2625 C C   . PRO C 3 120 ? 193.530 217.549 175.328 1.00 67.77 ? 120 PRO A C   1 
ATOM   2626 O O   . PRO C 3 120 ? 194.587 218.085 174.962 1.00 67.77 ? 120 PRO A O   1 
ATOM   2627 C CB  . PRO C 3 120 ? 191.287 218.467 174.607 1.00 67.77 ? 120 PRO A CB  1 
ATOM   2628 C CG  . PRO C 3 120 ? 191.705 219.629 173.786 1.00 67.77 ? 120 PRO A CG  1 
ATOM   2629 C CD  . PRO C 3 120 ? 192.340 220.624 174.722 1.00 67.77 ? 120 PRO A CD  1 
ATOM   2630 N N   . PRO C 3 121 ? 193.408 216.220 175.386 1.00 67.13 ? 121 PRO A N   1 
ATOM   2631 C CA  . PRO C 3 121 ? 194.578 215.361 175.158 1.00 67.13 ? 121 PRO A CA  1 
ATOM   2632 C C   . PRO C 3 121 ? 195.115 215.415 173.732 1.00 67.13 ? 121 PRO A C   1 
ATOM   2633 O O   . PRO C 3 121 ? 194.389 215.678 172.771 1.00 67.13 ? 121 PRO A O   1 
ATOM   2634 C CB  . PRO C 3 121 ? 194.054 213.958 175.493 1.00 67.13 ? 121 PRO A CB  1 
ATOM   2635 C CG  . PRO C 3 121 ? 192.575 214.057 175.361 1.00 67.13 ? 121 PRO A CG  1 
ATOM   2636 C CD  . PRO C 3 121 ? 192.235 215.437 175.813 1.00 67.13 ? 121 PRO A CD  1 
ATOM   2637 N N   . ASN C 3 122 ? 196.418 215.161 173.615 1.00 63.92 ? 122 ASN A N   1 
ATOM   2638 C CA  . ASN C 3 122 ? 197.128 215.035 172.344 1.00 63.92 ? 122 ASN A CA  1 
ATOM   2639 C C   . ASN C 3 122 ? 198.415 214.255 172.606 1.00 63.92 ? 122 ASN A C   1 
ATOM   2640 O O   . ASN C 3 122 ? 198.567 213.623 173.656 1.00 63.92 ? 122 ASN A O   1 
ATOM   2641 C CB  . ASN C 3 122 ? 197.390 216.407 171.718 1.00 63.92 ? 122 ASN A CB  1 
ATOM   2642 C CG  . ASN C 3 122 ? 197.726 216.318 170.247 1.00 63.92 ? 122 ASN A CG  1 
ATOM   2643 O OD1 . ASN C 3 122 ? 198.676 215.639 169.858 1.00 63.92 ? 122 ASN A OD1 1 
ATOM   2644 N ND2 . ASN C 3 122 ? 196.947 217.002 169.418 1.00 63.92 ? 122 ASN A ND2 1 
ATOM   2645 N N   . LEU C 3 123 ? 199.352 214.292 171.649 1.00 63.06 ? 123 LEU A N   1 
ATOM   2646 C CA  . LEU C 3 123 ? 200.576 213.502 171.749 1.00 63.06 ? 123 LEU A CA  1 
ATOM   2647 C C   . LEU C 3 123 ? 201.805 214.392 171.876 1.00 63.06 ? 123 LEU A C   1 
ATOM   2648 O O   . LEU C 3 123 ? 201.960 215.339 171.096 1.00 63.06 ? 123 LEU A O   1 
ATOM   2649 C CB  . LEU C 3 123 ? 200.718 212.588 170.532 1.00 63.06 ? 123 LEU A CB  1 
ATOM   2650 C CG  . LEU C 3 123 ? 200.122 211.195 170.737 1.00 63.06 ? 123 LEU A CG  1 
ATOM   2651 C CD1 . LEU C 3 123 ? 200.745 210.528 171.954 1.00 63.06 ? 123 LEU A CD1 1 
ATOM   2652 C CD2 . LEU C 3 123 ? 198.605 211.245 170.868 1.00 63.06 ? 123 LEU A CD2 1 
ATOM   2653 N N   . PRO C 3 124 ? 202.694 214.117 172.838 1.00 55.06 ? 124 PRO A N   1 
ATOM   2654 C CA  . PRO C 3 124 ? 203.768 215.066 173.168 1.00 55.06 ? 124 PRO A CA  1 
ATOM   2655 C C   . PRO C 3 124 ? 205.159 214.823 172.587 1.00 55.06 ? 124 PRO A C   1 
ATOM   2656 O O   . PRO C 3 124 ? 206.039 215.661 172.800 1.00 55.06 ? 124 PRO A O   1 
ATOM   2657 C CB  . PRO C 3 124 ? 203.822 214.962 174.692 1.00 55.06 ? 124 PRO A CB  1 
ATOM   2658 C CG  . PRO C 3 124 ? 203.527 213.516 174.940 1.00 55.06 ? 124 PRO A CG  1 
ATOM   2659 C CD  . PRO C 3 124 ? 202.545 213.084 173.875 1.00 55.06 ? 124 PRO A CD  1 
ATOM   2660 N N   . CYS C 3 125 ? 205.399 213.716 171.890 1.00 58.51 ? 125 CYS A N   1 
ATOM   2661 C CA  . CYS C 3 125 ? 206.764 213.303 171.574 1.00 58.51 ? 125 CYS A CA  1 
ATOM   2662 C C   . CYS C 3 125 ? 207.281 213.941 170.285 1.00 58.51 ? 125 CYS A C   1 
ATOM   2663 O O   . CYS C 3 125 ? 206.546 214.582 169.533 1.00 58.51 ? 125 CYS A O   1 
ATOM   2664 C CB  . CYS C 3 125 ? 206.847 211.784 171.468 1.00 58.51 ? 125 CYS A CB  1 
ATOM   2665 S SG  . CYS C 3 125 ? 206.137 211.127 169.956 1.00 58.51 ? 125 CYS A SG  1 
ATOM   2666 N N   . SER C 3 126 ? 208.578 213.749 170.036 1.00 57.69 ? 126 SER A N   1 
ATOM   2667 C CA  . SER C 3 126 ? 209.261 214.273 168.861 1.00 57.69 ? 126 SER A CA  1 
ATOM   2668 C C   . SER C 3 126 ? 209.982 213.144 168.138 1.00 57.69 ? 126 SER A C   1 
ATOM   2669 O O   . SER C 3 126 ? 209.999 211.997 168.593 1.00 57.69 ? 126 SER A O   1 
ATOM   2670 C CB  . SER C 3 126 ? 210.260 215.373 169.235 1.00 57.69 ? 126 SER A CB  1 
ATOM   2671 O OG  . SER C 3 126 ? 209.615 216.441 169.904 1.00 57.69 ? 126 SER A OG  1 
ATOM   2672 N N   . VAL C 3 127 ? 210.587 213.476 166.999 1.00 60.95 ? 127 VAL A N   1 
ATOM   2673 C CA  . VAL C 3 127 ? 211.337 212.513 166.203 1.00 60.95 ? 127 VAL A CA  1 
ATOM   2674 C C   . VAL C 3 127 ? 212.806 212.909 166.212 1.00 60.95 ? 127 VAL A C   1 
ATOM   2675 O O   . VAL C 3 127 ? 213.173 214.041 166.543 1.00 60.95 ? 127 VAL A O   1 
ATOM   2676 C CB  . VAL C 3 127 ? 210.812 212.400 164.757 1.00 60.95 ? 127 VAL A CB  1 
ATOM   2677 C CG1 . VAL C 3 127 ? 209.382 211.892 164.740 1.00 60.95 ? 127 VAL A CG1 1 
ATOM   2678 C CG2 . VAL C 3 127 ? 210.917 213.733 164.056 1.00 60.95 ? 127 VAL A CG2 1 
ATOM   2679 N N   . THR C 3 128 ? 213.659 211.955 165.845 1.00 62.68 ? 128 THR A N   1 
ATOM   2680 C CA  . THR C 3 128 ? 215.094 212.182 165.908 1.00 62.68 ? 128 THR A CA  1 
ATOM   2681 C C   . THR C 3 128 ? 215.539 213.167 164.832 1.00 62.68 ? 128 THR A C   1 
ATOM   2682 O O   . THR C 3 128 ? 214.883 213.354 163.805 1.00 62.68 ? 128 THR A O   1 
ATOM   2683 C CB  . THR C 3 128 ? 215.865 210.875 165.751 1.00 62.68 ? 128 THR A CB  1 
ATOM   2684 O OG1 . THR C 3 128 ? 217.264 211.127 165.921 1.00 62.68 ? 128 THR A OG1 1 
ATOM   2685 C CG2 . THR C 3 128 ? 215.633 210.291 164.374 1.00 62.68 ? 128 THR A CG2 1 
ATOM   2686 N N   . LEU C 3 129 ? 216.679 213.803 165.088 1.00 66.78 ? 129 LEU A N   1 
ATOM   2687 C CA  . LEU C 3 129 ? 217.210 214.853 164.223 1.00 66.78 ? 129 LEU A CA  1 
ATOM   2688 C C   . LEU C 3 129 ? 218.309 214.248 163.358 1.00 66.78 ? 129 LEU A C   1 
ATOM   2689 O O   . LEU C 3 129 ? 219.489 214.272 163.709 1.00 66.78 ? 129 LEU A O   1 
ATOM   2690 C CB  . LEU C 3 129 ? 217.723 216.027 165.050 1.00 66.78 ? 129 LEU A CB  1 
ATOM   2691 C CG  . LEU C 3 129 ? 216.722 216.664 166.016 1.00 66.78 ? 129 LEU A CG  1 
ATOM   2692 C CD1 . LEU C 3 129 ? 217.365 217.813 166.776 1.00 66.78 ? 129 LEU A CD1 1 
ATOM   2693 C CD2 . LEU C 3 129 ? 215.481 217.136 165.273 1.00 66.78 ? 129 LEU A CD2 1 
ATOM   2694 N N   . GLN C 3 130 ? 217.910 213.698 162.219 1.00 72.35 ? 130 GLN A N   1 
ATOM   2695 C CA  . GLN C 3 130 ? 218.826 213.166 161.227 1.00 72.35 ? 130 GLN A CA  1 
ATOM   2696 C C   . GLN C 3 130 ? 218.414 213.651 159.846 1.00 72.35 ? 130 GLN A C   1 
ATOM   2697 O O   . GLN C 3 130 ? 217.223 213.842 159.583 1.00 72.35 ? 130 GLN A O   1 
ATOM   2698 C CB  . GLN C 3 130 ? 218.842 211.631 161.249 1.00 72.35 ? 130 GLN A CB  1 
ATOM   2699 C CG  . GLN C 3 130 ? 219.789 211.033 162.276 1.00 72.35 ? 130 GLN A CG  1 
ATOM   2700 C CD  . GLN C 3 130 ? 221.193 210.850 161.735 1.00 72.35 ? 130 GLN A CD  1 
ATOM   2701 O OE1 . GLN C 3 130 ? 221.400 210.786 160.524 1.00 72.35 ? 130 GLN A OE1 1 
ATOM   2702 N NE2 . GLN C 3 130 ? 222.167 210.766 162.634 1.00 72.35 ? 130 GLN A NE2 1 
ATOM   2703 N N   . PRO C 3 131 ? 219.375 213.866 158.948 1.00 73.57 ? 131 PRO A N   1 
ATOM   2704 C CA  . PRO C 3 131 ? 219.022 214.285 157.584 1.00 73.57 ? 131 PRO A CA  1 
ATOM   2705 C C   . PRO C 3 131 ? 218.274 213.180 156.851 1.00 73.57 ? 131 PRO A C   1 
ATOM   2706 O O   . PRO C 3 131 ? 218.640 212.006 156.928 1.00 73.57 ? 131 PRO A O   1 
ATOM   2707 C CB  . PRO C 3 131 ? 220.380 214.581 156.936 1.00 73.57 ? 131 PRO A CB  1 
ATOM   2708 C CG  . PRO C 3 131 ? 221.371 213.820 157.748 1.00 73.57 ? 131 PRO A CG  1 
ATOM   2709 C CD  . PRO C 3 131 ? 220.833 213.794 159.148 1.00 73.57 ? 131 PRO A CD  1 
ATOM   2710 N N   . GLY C 3 132 ? 217.218 213.568 156.140 1.00 74.68 ? 132 GLY A N   1 
ATOM   2711 C CA  . GLY C 3 132 ? 216.429 212.639 155.366 1.00 74.68 ? 132 GLY A CA  1 
ATOM   2712 C C   . GLY C 3 132 ? 215.625 211.670 156.212 1.00 74.68 ? 132 GLY A C   1 
ATOM   2713 O O   . GLY C 3 132 ? 215.885 210.463 156.225 1.00 74.68 ? 132 GLY A O   1 
ATOM   2714 N N   . PRO C 3 133 ? 214.621 212.178 156.932 1.00 76.49 ? 133 PRO A N   1 
ATOM   2715 C CA  . PRO C 3 133 ? 213.812 211.297 157.783 1.00 76.49 ? 133 PRO A CA  1 
ATOM   2716 C C   . PRO C 3 133 ? 212.856 210.427 156.983 1.00 76.49 ? 133 PRO A C   1 
ATOM   2717 O O   . PRO C 3 133 ? 212.892 210.417 155.749 1.00 76.49 ? 133 PRO A O   1 
ATOM   2718 C CB  . PRO C 3 133 ? 213.057 212.281 158.682 1.00 76.49 ? 133 PRO A CB  1 
ATOM   2719 C CG  . PRO C 3 133 ? 212.919 213.496 157.846 1.00 76.49 ? 133 PRO A CG  1 
ATOM   2720 C CD  . PRO C 3 133 ? 214.169 213.579 157.007 1.00 76.49 ? 133 PRO A CD  1 
ATOM   2721 N N   . GLU C 3 134 ? 212.001 209.686 157.683 1.00 74.71 ? 134 GLU A N   1 
ATOM   2722 C CA  . GLU C 3 134 ? 211.052 208.775 157.058 1.00 74.71 ? 134 GLU A CA  1 
ATOM   2723 C C   . GLU C 3 134 ? 209.672 209.391 156.870 1.00 74.71 ? 134 GLU A C   1 
ATOM   2724 O O   . GLU C 3 134 ? 208.751 208.692 156.441 1.00 74.71 ? 134 GLU A O   1 
ATOM   2725 C CB  . GLU C 3 134 ? 210.934 207.494 157.888 1.00 74.71 ? 134 GLU A CB  1 
ATOM   2726 C CG  . GLU C 3 134 ? 212.254 207.000 158.456 1.00 74.71 ? 134 GLU A CG  1 
ATOM   2727 C CD  . GLU C 3 134 ? 213.204 206.499 157.389 1.00 74.71 ? 134 GLU A CD  1 
ATOM   2728 O OE1 . GLU C 3 134 ? 212.730 206.118 156.299 1.00 74.71 ? 134 GLU A OE1 1 
ATOM   2729 O OE2 . GLU C 3 134 ? 214.427 206.486 157.640 1.00 74.71 ? 134 GLU A OE2 1 
ATOM   2730 N N   . ASP C 3 135 ? 209.506 210.676 157.181 1.00 75.67 ? 135 ASP A N   1 
ATOM   2731 C CA  . ASP C 3 135 ? 208.206 211.326 157.098 1.00 75.67 ? 135 ASP A CA  1 
ATOM   2732 C C   . ASP C 3 135 ? 208.318 212.609 156.289 1.00 75.67 ? 135 ASP A C   1 
ATOM   2733 O O   . ASP C 3 135 ? 209.401 213.010 155.857 1.00 75.67 ? 135 ASP A O   1 
ATOM   2734 C CB  . ASP C 3 135 ? 207.637 211.627 158.487 1.00 75.67 ? 135 ASP A CB  1 
ATOM   2735 C CG  . ASP C 3 135 ? 206.830 210.480 159.042 1.00 75.67 ? 135 ASP A CG  1 
ATOM   2736 O OD1 . ASP C 3 135 ? 205.904 210.742 159.835 1.00 75.67 ? 135 ASP A OD1 1 
ATOM   2737 O OD2 . ASP C 3 135 ? 207.121 209.319 158.688 1.00 75.67 ? 135 ASP A OD2 1 
ATOM   2738 N N   . THR C 3 136 ? 207.169 213.249 156.084 1.00 76.38 ? 136 THR A N   1 
ATOM   2739 C CA  . THR C 3 136 ? 207.128 214.520 155.373 1.00 76.38 ? 136 THR A CA  1 
ATOM   2740 C C   . THR C 3 136 ? 207.787 215.619 156.200 1.00 76.38 ? 136 THR A C   1 
ATOM   2741 O O   . THR C 3 136 ? 207.516 215.762 157.396 1.00 76.38 ? 136 THR A O   1 
ATOM   2742 C CB  . THR C 3 136 ? 205.680 214.892 155.053 1.00 76.38 ? 136 THR A CB  1 
ATOM   2743 O OG1 . THR C 3 136 ? 204.874 214.734 156.227 1.00 76.38 ? 136 THR A OG1 1 
ATOM   2744 C CG2 . THR C 3 136 ? 205.133 213.998 153.958 1.00 76.38 ? 136 THR A CG2 1 
ATOM   2745 N N   . GLY C 3 137 ? 208.649 216.403 155.555 1.00 79.49 ? 137 GLY A N   1 
ATOM   2746 C CA  . GLY C 3 137 ? 209.366 217.465 156.230 1.00 79.49 ? 137 GLY A CA  1 
ATOM   2747 C C   . GLY C 3 137 ? 210.693 217.015 156.810 1.00 79.49 ? 137 GLY A C   1 
ATOM   2748 O O   . GLY C 3 137 ? 211.102 215.855 156.720 1.00 79.49 ? 137 GLY A O   1 
ATOM   2749 N N   . LYS C 3 138 ? 211.384 217.975 157.424 1.00 82.92 ? 138 LYS A N   1 
ATOM   2750 C CA  . LYS C 3 138 ? 212.685 217.744 158.035 1.00 82.92 ? 138 LYS A CA  1 
ATOM   2751 C C   . LYS C 3 138 ? 212.689 218.299 159.453 1.00 82.92 ? 138 LYS A C   1 
ATOM   2752 O O   . LYS C 3 138 ? 212.094 219.345 159.726 1.00 82.92 ? 138 LYS A O   1 
ATOM   2753 C CB  . LYS C 3 138 ? 213.815 218.392 157.217 1.00 82.92 ? 138 LYS A CB  1 
ATOM   2754 C CG  . LYS C 3 138 ? 215.215 218.093 157.735 1.00 82.92 ? 138 LYS A CG  1 
ATOM   2755 C CD  . LYS C 3 138 ? 216.282 218.565 156.763 1.00 82.92 ? 138 LYS A CD  1 
ATOM   2756 C CE  . LYS C 3 138 ? 216.378 220.082 156.744 1.00 82.92 ? 138 LYS A CE  1 
ATOM   2757 N NZ  . LYS C 3 138 ? 217.542 220.555 155.945 1.00 82.92 ? 138 LYS A NZ  1 
ATOM   2758 N N   . ALA C 3 139 ? 213.376 217.586 160.349 1.00 81.09 ? 139 ALA A N   1 
ATOM   2759 C CA  . ALA C 3 139 ? 213.466 217.950 161.765 1.00 81.09 ? 139 ALA A CA  1 
ATOM   2760 C C   . ALA C 3 139 ? 212.075 218.091 162.379 1.00 81.09 ? 139 ALA A C   1 
ATOM   2761 O O   . ALA C 3 139 ? 211.723 219.115 162.969 1.00 81.09 ? 139 ALA A O   1 
ATOM   2762 C CB  . ALA C 3 139 ? 214.287 219.227 161.955 1.00 81.09 ? 139 ALA A CB  1 
ATOM   2763 N N   . CYS C 3 140 ? 211.278 217.036 162.234 1.00 75.35 ? 140 CYS A N   1 
ATOM   2764 C CA  . CYS C 3 140 ? 209.871 217.090 162.590 1.00 75.35 ? 140 CYS A CA  1 
ATOM   2765 C C   . CYS C 3 140 ? 209.692 216.988 164.104 1.00 75.35 ? 140 CYS A C   1 
ATOM   2766 O O   . CYS C 3 140 ? 210.650 217.009 164.881 1.00 75.35 ? 140 CYS A O   1 
ATOM   2767 C CB  . CYS C 3 140 ? 209.107 215.981 161.871 1.00 75.35 ? 140 CYS A CB  1 
ATOM   2768 S SG  . CYS C 3 140 ? 209.614 215.722 160.154 1.00 75.35 ? 140 CYS A SG  1 
ATOM   2769 N N   . GLY C 3 141 ? 208.442 216.885 164.519 1.00 68.01 ? 141 GLY A N   1 
ATOM   2770 C CA  . GLY C 3 141 ? 208.100 216.743 165.921 1.00 68.01 ? 141 GLY A CA  1 
ATOM   2771 C C   . GLY C 3 141 ? 206.793 217.440 166.227 1.00 68.01 ? 141 GLY A C   1 
ATOM   2772 O O   . GLY C 3 141 ? 206.243 218.177 165.413 1.00 68.01 ? 141 GLY A O   1 
ATOM   2773 N N   . VAL C 3 142 ? 206.295 217.190 167.434 1.00 60.52 ? 142 VAL A N   1 
ATOM   2774 C CA  . VAL C 3 142 ? 205.117 217.873 167.957 1.00 60.52 ? 142 VAL A CA  1 
ATOM   2775 C C   . VAL C 3 142 ? 205.514 218.571 169.247 1.00 60.52 ? 142 VAL A C   1 
ATOM   2776 O O   . VAL C 3 142 ? 206.013 217.929 170.178 1.00 60.52 ? 142 VAL A O   1 
ATOM   2777 C CB  . VAL C 3 142 ? 203.950 216.909 168.195 1.00 60.52 ? 142 VAL A CB  1 
ATOM   2778 C CG1 . VAL C 3 142 ? 202.866 217.594 168.994 1.00 60.52 ? 142 VAL A CG1 1 
ATOM   2779 C CG2 . VAL C 3 142 ? 203.397 216.433 166.875 1.00 60.52 ? 142 VAL A CG2 1 
ATOM   2780 N N   . ASP C 3 143 ? 205.288 219.880 169.304 1.00 62.09 ? 143 ASP A N   1 
ATOM   2781 C CA  . ASP C 3 143 ? 205.665 220.674 170.460 1.00 62.09 ? 143 ASP A CA  1 
ATOM   2782 C C   . ASP C 3 143 ? 204.551 221.650 170.805 1.00 62.09 ? 143 ASP A C   1 
ATOM   2783 O O   . ASP C 3 143 ? 203.796 222.092 169.937 1.00 62.09 ? 143 ASP A O   1 
ATOM   2784 C CB  . ASP C 3 143 ? 206.980 221.424 170.213 1.00 62.09 ? 143 ASP A CB  1 
ATOM   2785 C CG  . ASP C 3 143 ? 206.941 222.276 168.959 1.00 62.09 ? 143 ASP A CG  1 
ATOM   2786 O OD1 . ASP C 3 143 ? 205.978 222.146 168.176 1.00 62.09 ? 143 ASP A OD1 1 
ATOM   2787 O OD2 . ASP C 3 143 ? 207.880 223.074 168.752 1.00 62.09 ? 143 ASP A OD2 1 
ATOM   2788 N N   . TYR C 3 144 ? 204.458 221.976 172.090 1.00 57.89 ? 144 TYR A N   1 
ATOM   2789 C CA  . TYR C 3 144 ? 203.520 222.957 172.609 1.00 57.89 ? 144 TYR A CA  1 
ATOM   2790 C C   . TYR C 3 144 ? 204.249 224.279 172.799 1.00 57.89 ? 144 TYR A C   1 
ATOM   2791 O O   . TYR C 3 144 ? 205.468 224.307 172.981 1.00 57.89 ? 144 TYR A O   1 
ATOM   2792 C CB  . TYR C 3 144 ? 202.924 222.495 173.935 1.00 57.89 ? 144 TYR A CB  1 
ATOM   2793 C CG  . TYR C 3 144 ? 201.829 221.471 173.791 1.00 57.89 ? 144 TYR A CG  1 
ATOM   2794 C CD1 . TYR C 3 144 ? 201.976 220.382 172.950 1.00 57.89 ? 144 TYR A CD1 1 
ATOM   2795 C CD2 . TYR C 3 144 ? 200.645 221.597 174.494 1.00 57.89 ? 144 TYR A CD2 1 
ATOM   2796 C CE1 . TYR C 3 144 ? 200.974 219.448 172.818 1.00 57.89 ? 144 TYR A CE1 1 
ATOM   2797 C CE2 . TYR C 3 144 ? 199.643 220.672 174.367 1.00 57.89 ? 144 TYR A CE2 1 
ATOM   2798 C CZ  . TYR C 3 144 ? 199.812 219.600 173.529 1.00 57.89 ? 144 TYR A CZ  1 
ATOM   2799 O OH  . TYR C 3 144 ? 198.807 218.675 173.404 1.00 57.89 ? 144 TYR A OH  1 
ATOM   2800 N N   . GLU C 3 145 ? 203.506 225.380 172.751 1.00 56.32 ? 145 GLU A N   1 
ATOM   2801 C CA  . GLU C 3 145 ? 204.156 226.685 172.691 1.00 56.32 ? 145 GLU A CA  1 
ATOM   2802 C C   . GLU C 3 145 ? 203.252 227.749 173.295 1.00 56.32 ? 145 GLU A C   1 
ATOM   2803 O O   . GLU C 3 145 ? 202.194 228.058 172.742 1.00 56.32 ? 145 GLU A O   1 
ATOM   2804 C CB  . GLU C 3 145 ? 204.517 227.028 171.252 1.00 56.32 ? 145 GLU A CB  1 
ATOM   2805 C CG  . GLU C 3 145 ? 205.018 228.435 171.046 1.00 56.32 ? 145 GLU A CG  1 
ATOM   2806 C CD  . GLU C 3 145 ? 206.069 228.506 169.963 1.00 56.32 ? 145 GLU A CD  1 
ATOM   2807 O OE1 . GLU C 3 145 ? 206.700 229.571 169.809 1.00 56.32 ? 145 GLU A OE1 1 
ATOM   2808 O OE2 . GLU C 3 145 ? 206.266 227.492 169.262 1.00 56.32 ? 145 GLU A OE2 1 
ATOM   2809 N N   . VAL C 3 146 ? 203.680 228.307 174.420 1.00 51.39 ? 146 VAL A N   1 
ATOM   2810 C CA  . VAL C 3 146 ? 203.036 229.475 175.006 1.00 51.39 ? 146 VAL A CA  1 
ATOM   2811 C C   . VAL C 3 146 ? 203.639 230.718 174.378 1.00 51.39 ? 146 VAL A C   1 
ATOM   2812 O O   . VAL C 3 146 ? 204.855 230.802 174.183 1.00 51.39 ? 146 VAL A O   1 
ATOM   2813 C CB  . VAL C 3 146 ? 203.211 229.479 176.532 1.00 51.39 ? 146 VAL A CB  1 
ATOM   2814 C CG1 . VAL C 3 146 ? 202.321 230.524 177.161 1.00 51.39 ? 146 VAL A CG1 1 
ATOM   2815 C CG2 . VAL C 3 146 ? 202.908 228.115 177.098 1.00 51.39 ? 146 VAL A CG2 1 
ATOM   2816 N N   . LYS C 3 147 ? 202.799 231.691 174.054 1.00 53.08 ? 147 LYS A N   1 
ATOM   2817 C CA  . LYS C 3 147 ? 203.285 232.863 173.345 1.00 53.08 ? 147 LYS A CA  1 
ATOM   2818 C C   . LYS C 3 147 ? 202.426 234.064 173.698 1.00 53.08 ? 147 LYS A C   1 
ATOM   2819 O O   . LYS C 3 147 ? 201.199 233.962 173.743 1.00 53.08 ? 147 LYS A O   1 
ATOM   2820 C CB  . LYS C 3 147 ? 203.278 232.627 171.832 1.00 53.08 ? 147 LYS A CB  1 
ATOM   2821 C CG  . LYS C 3 147 ? 203.185 233.895 170.998 1.00 53.08 ? 147 LYS A CG  1 
ATOM   2822 C CD  . LYS C 3 147 ? 203.449 233.626 169.527 1.00 53.08 ? 147 LYS A CD  1 
ATOM   2823 C CE  . LYS C 3 147 ? 202.712 232.390 169.036 1.00 53.08 ? 147 LYS A CE  1 
ATOM   2824 N NZ  . LYS C 3 147 ? 201.246 232.481 169.269 1.00 53.08 ? 147 LYS A NZ  1 
ATOM   2825 N N   . ALA C 3 148 ? 203.077 235.198 173.939 1.00 51.80 ? 148 ALA A N   1 
ATOM   2826 C CA  . ALA C 3 148 ? 202.387 236.451 174.182 1.00 51.80 ? 148 ALA A CA  1 
ATOM   2827 C C   . ALA C 3 148 ? 202.917 237.505 173.226 1.00 51.80 ? 148 ALA A C   1 
ATOM   2828 O O   . ALA C 3 148 ? 204.111 237.543 172.927 1.00 51.80 ? 148 ALA A O   1 
ATOM   2829 C CB  . ALA C 3 148 ? 202.555 236.914 175.629 1.00 51.80 ? 148 ALA A CB  1 
ATOM   2830 N N   . PHE C 3 149 ? 202.023 238.359 172.737 1.00 56.27 ? 149 PHE A N   1 
ATOM   2831 C CA  . PHE C 3 149 ? 202.449 239.388 171.802 1.00 56.27 ? 149 PHE A CA  1 
ATOM   2832 C C   . PHE C 3 149 ? 201.553 240.608 171.930 1.00 56.27 ? 149 PHE A C   1 
ATOM   2833 O O   . PHE C 3 149 ? 200.428 240.531 172.427 1.00 56.27 ? 149 PHE A O   1 
ATOM   2834 C CB  . PHE C 3 149 ? 202.478 238.865 170.359 1.00 56.27 ? 149 PHE A CB  1 
ATOM   2835 C CG  . PHE C 3 149 ? 201.152 238.382 169.844 1.00 56.27 ? 149 PHE A CG  1 
ATOM   2836 C CD1 . PHE C 3 149 ? 200.589 237.213 170.317 1.00 56.27 ? 149 PHE A CD1 1 
ATOM   2837 C CD2 . PHE C 3 149 ? 200.490 239.081 168.853 1.00 56.27 ? 149 PHE A CD2 1 
ATOM   2838 C CE1 . PHE C 3 149 ? 199.378 236.766 169.833 1.00 56.27 ? 149 PHE A CE1 1 
ATOM   2839 C CE2 . PHE C 3 149 ? 199.282 238.638 168.364 1.00 56.27 ? 149 PHE A CE2 1 
ATOM   2840 C CZ  . PHE C 3 149 ? 198.725 237.479 168.854 1.00 56.27 ? 149 PHE A CZ  1 
ATOM   2841 N N   . CYS C 3 150 ? 202.073 241.740 171.469 1.00 61.77 ? 150 CYS A N   1 
ATOM   2842 C CA  . CYS C 3 150 ? 201.443 243.038 171.645 1.00 61.77 ? 150 CYS A CA  1 
ATOM   2843 C C   . CYS C 3 150 ? 201.028 243.618 170.304 1.00 61.77 ? 150 CYS A C   1 
ATOM   2844 O O   . CYS C 3 150 ? 201.800 243.594 169.341 1.00 61.77 ? 150 CYS A O   1 
ATOM   2845 C CB  . CYS C 3 150 ? 202.391 244.012 172.346 1.00 61.77 ? 150 CYS A CB  1 
ATOM   2846 S SG  . CYS C 3 150 ? 203.986 244.204 171.532 1.00 61.77 ? 150 CYS A SG  1 
ATOM   2847 N N   . ALA C 3 151 ? 199.814 244.151 170.255 1.00 68.63 ? 151 ALA A N   1 
ATOM   2848 C CA  . ALA C 3 151 ? 199.282 244.803 169.065 1.00 68.63 ? 151 ALA A CA  1 
ATOM   2849 C C   . ALA C 3 151 ? 197.961 245.458 169.443 1.00 68.63 ? 151 ALA A C   1 
ATOM   2850 O O   . ALA C 3 151 ? 197.522 245.401 170.595 1.00 68.63 ? 151 ALA A O   1 
ATOM   2851 C CB  . ALA C 3 151 ? 199.095 243.816 167.910 1.00 68.63 ? 151 ALA A CB  1 
ATOM   2852 N N   . GLU C 3 152 ? 197.328 246.083 168.455 1.00 72.38 ? 152 GLU A N   1 
ATOM   2853 C CA  . GLU C 3 152 ? 195.984 246.619 168.605 1.00 72.38 ? 152 GLU A CA  1 
ATOM   2854 C C   . GLU C 3 152 ? 194.919 245.709 168.013 1.00 72.38 ? 152 GLU A C   1 
ATOM   2855 O O   . GLU C 3 152 ? 193.792 245.682 168.517 1.00 72.38 ? 152 GLU A O   1 
ATOM   2856 C CB  . GLU C 3 152 ? 195.895 247.999 167.945 1.00 72.38 ? 152 GLU A CB  1 
ATOM   2857 C CG  . GLU C 3 152 ? 197.050 248.931 168.291 1.00 72.38 ? 152 GLU A CG  1 
ATOM   2858 C CD  . GLU C 3 152 ? 198.131 248.956 167.219 1.00 72.38 ? 152 GLU A CD  1 
ATOM   2859 O OE1 . GLU C 3 152 ? 198.099 248.093 166.317 1.00 72.38 ? 152 GLU A OE1 1 
ATOM   2860 O OE2 . GLU C 3 152 ? 199.013 249.838 167.277 1.00 72.38 ? 152 GLU A OE2 1 
ATOM   2861 N N   . ASN C 3 153 ? 195.252 244.961 166.965 1.00 73.00 ? 153 ASN A N   1 
ATOM   2862 C CA  . ASN C 3 153 ? 194.318 244.061 166.309 1.00 73.00 ? 153 ASN A CA  1 
ATOM   2863 C C   . ASN C 3 153 ? 195.024 242.746 166.010 1.00 73.00 ? 153 ASN A C   1 
ATOM   2864 O O   . ASN C 3 153 ? 196.251 242.690 165.895 1.00 73.00 ? 153 ASN A O   1 
ATOM   2865 C CB  . ASN C 3 153 ? 193.758 244.681 165.025 1.00 73.00 ? 153 ASN A CB  1 
ATOM   2866 C CG  . ASN C 3 153 ? 192.972 245.950 165.289 1.00 73.00 ? 153 ASN A CG  1 
ATOM   2867 O OD1 . ASN C 3 153 ? 191.783 245.904 165.603 1.00 73.00 ? 153 ASN A OD1 1 
ATOM   2868 N ND2 . ASN C 3 153 ? 193.638 247.093 165.173 1.00 73.00 ? 153 ASN A ND2 1 
ATOM   2869 N N   . LEU C 3 154 ? 194.229 241.683 165.871 1.00 67.55 ? 154 LEU A N   1 
ATOM   2870 C CA  . LEU C 3 154 ? 194.739 240.319 165.805 1.00 67.55 ? 154 LEU A CA  1 
ATOM   2871 C C   . LEU C 3 154 ? 195.124 239.884 164.396 1.00 67.55 ? 154 LEU A C   1 
ATOM   2872 O O   . LEU C 3 154 ? 195.124 238.682 164.110 1.00 67.55 ? 154 LEU A O   1 
ATOM   2873 C CB  . LEU C 3 154 ? 193.714 239.346 166.386 1.00 67.55 ? 154 LEU A CB  1 
ATOM   2874 C CG  . LEU C 3 154 ? 193.344 239.588 167.846 1.00 67.55 ? 154 LEU A CG  1 
ATOM   2875 C CD1 . LEU C 3 154 ? 191.981 240.256 167.938 1.00 67.55 ? 154 LEU A CD1 1 
ATOM   2876 C CD2 . LEU C 3 154 ? 193.372 238.284 168.634 1.00 67.55 ? 154 LEU A CD2 1 
ATOM   2877 N N   . GLU C 3 155 ? 195.450 240.823 163.510 1.00 68.62 ? 155 GLU A N   1 
ATOM   2878 C CA  . GLU C 3 155 ? 195.941 240.480 162.185 1.00 68.62 ? 155 GLU A CA  1 
ATOM   2879 C C   . GLU C 3 155 ? 197.150 241.291 161.743 1.00 68.62 ? 155 GLU A C   1 
ATOM   2880 O O   . GLU C 3 155 ? 197.680 241.026 160.659 1.00 68.62 ? 155 GLU A O   1 
ATOM   2881 C CB  . GLU C 3 155 ? 194.827 240.647 161.140 1.00 68.62 ? 155 GLU A CB  1 
ATOM   2882 N N   . GLU C 3 156 ? 197.615 242.244 162.545 1.00 73.25 ? 156 GLU A N   1 
ATOM   2883 C CA  . GLU C 3 156 ? 198.629 243.191 162.109 1.00 73.25 ? 156 GLU A CA  1 
ATOM   2884 C C   . GLU C 3 156 ? 200.007 242.532 162.063 1.00 73.25 ? 156 GLU A C   1 
ATOM   2885 O O   . GLU C 3 156 ? 200.169 241.328 162.285 1.00 73.25 ? 156 GLU A O   1 
ATOM   2886 C CB  . GLU C 3 156 ? 198.644 244.407 163.032 1.00 73.25 ? 156 GLU A CB  1 
ATOM   2887 C CG  . GLU C 3 156 ? 197.647 245.488 162.658 1.00 73.25 ? 156 GLU A CG  1 
ATOM   2888 C CD  . GLU C 3 156 ? 198.118 246.326 161.488 1.00 73.25 ? 156 GLU A CD  1 
ATOM   2889 O OE1 . GLU C 3 156 ? 199.331 246.304 161.192 1.00 73.25 ? 156 GLU A OE1 1 
ATOM   2890 O OE2 . GLU C 3 156 ? 197.276 247.006 160.865 1.00 73.25 ? 156 GLU A OE2 1 
ATOM   2891 N N   . LYS C 3 157 ? 201.014 243.351 161.760 1.00 70.20 ? 157 LYS A N   1 
ATOM   2892 C CA  . LYS C 3 157 ? 202.392 242.887 161.716 1.00 70.20 ? 157 LYS A CA  1 
ATOM   2893 C C   . LYS C 3 157 ? 202.925 242.653 163.123 1.00 70.20 ? 157 LYS A C   1 
ATOM   2894 O O   . LYS C 3 157 ? 202.510 243.302 164.087 1.00 70.20 ? 157 LYS A O   1 
ATOM   2895 C CB  . LYS C 3 157 ? 203.274 243.896 160.986 1.00 70.20 ? 157 LYS A CB  1 
ATOM   2896 N N   . ILE C 3 158 ? 203.865 241.718 163.229 1.00 65.72 ? 158 ILE A N   1 
ATOM   2897 C CA  . ILE C 3 158 ? 204.391 241.250 164.506 1.00 65.72 ? 158 ILE A CA  1 
ATOM   2898 C C   . ILE C 3 158 ? 205.832 241.717 164.636 1.00 65.72 ? 158 ILE A C   1 
ATOM   2899 O O   . ILE C 3 158 ? 206.654 241.474 163.745 1.00 65.72 ? 158 ILE A O   1 
ATOM   2900 C CB  . ILE C 3 158 ? 204.290 239.720 164.622 1.00 65.72 ? 158 ILE A CB  1 
ATOM   2901 C CG1 . ILE C 3 158 ? 202.826 239.290 164.720 1.00 65.72 ? 158 ILE A CG1 1 
ATOM   2902 C CG2 . ILE C 3 158 ? 205.053 239.230 165.833 1.00 65.72 ? 158 ILE A CG2 1 
ATOM   2903 C CD1 . ILE C 3 158 ? 202.193 238.924 163.399 1.00 65.72 ? 158 ILE A CD1 1 
ATOM   2904 N N   . HIS C 3 159 ? 206.135 242.394 165.744 1.00 68.64 ? 159 HIS A N   1 
ATOM   2905 C CA  . HIS C 3 159 ? 207.477 242.886 166.037 1.00 68.64 ? 159 HIS A CA  1 
ATOM   2906 C C   . HIS C 3 159 ? 208.137 241.937 167.030 1.00 68.64 ? 159 HIS A C   1 
ATOM   2907 O O   . HIS C 3 159 ? 207.783 241.920 168.214 1.00 68.64 ? 159 HIS A O   1 
ATOM   2908 C CB  . HIS C 3 159 ? 207.425 244.308 166.582 1.00 68.64 ? 159 HIS A CB  1 
ATOM   2909 C CG  . HIS C 3 159 ? 207.346 245.354 165.516 1.00 68.64 ? 159 HIS A CG  1 
ATOM   2910 N ND1 . HIS C 3 159 ? 207.497 245.063 164.178 1.00 68.64 ? 159 HIS A ND1 1 
ATOM   2911 C CD2 . HIS C 3 159 ? 207.124 246.688 165.588 1.00 68.64 ? 159 HIS A CD2 1 
ATOM   2912 C CE1 . HIS C 3 159 ? 207.375 246.172 163.471 1.00 68.64 ? 159 HIS A CE1 1 
ATOM   2913 N NE2 . HIS C 3 159 ? 207.148 247.173 164.303 1.00 68.64 ? 159 HIS A NE2 1 
ATOM   2914 N N   . LYS C 3 160 ? 209.107 241.162 166.542 1.00 68.49 ? 160 LYS A N   1 
ATOM   2915 C CA  . LYS C 3 160 ? 209.685 240.085 167.337 1.00 68.49 ? 160 LYS A CA  1 
ATOM   2916 C C   . LYS C 3 160 ? 210.289 240.599 168.633 1.00 68.49 ? 160 LYS A C   1 
ATOM   2917 O O   . LYS C 3 160 ? 210.276 239.894 169.647 1.00 68.49 ? 160 LYS A O   1 
ATOM   2918 C CB  . LYS C 3 160 ? 210.741 239.346 166.517 1.00 68.49 ? 160 LYS A CB  1 
ATOM   2919 C CG  . LYS C 3 160 ? 210.211 238.738 165.229 1.00 68.49 ? 160 LYS A CG  1 
ATOM   2920 C CD  . LYS C 3 160 ? 211.344 238.239 164.349 1.00 68.49 ? 160 LYS A CD  1 
ATOM   2921 C CE  . LYS C 3 160 ? 212.165 237.175 165.057 1.00 68.49 ? 160 LYS A CE  1 
ATOM   2922 N NZ  . LYS C 3 160 ? 211.413 235.900 165.208 1.00 68.49 ? 160 LYS A NZ  1 
ATOM   2923 N N   . ARG C 3 161 ? 210.826 241.817 168.621 1.00 70.37 ? 161 ARG A N   1 
ATOM   2924 C CA  . ARG C 3 161 ? 211.372 242.395 169.839 1.00 70.37 ? 161 ARG A CA  1 
ATOM   2925 C C   . ARG C 3 161 ? 210.300 242.650 170.890 1.00 70.37 ? 161 ARG A C   1 
ATOM   2926 O O   . ARG C 3 161 ? 210.611 242.658 172.085 1.00 70.37 ? 161 ARG A O   1 
ATOM   2927 C CB  . ARG C 3 161 ? 212.112 243.692 169.514 1.00 70.37 ? 161 ARG A CB  1 
ATOM   2928 C CG  . ARG C 3 161 ? 213.266 243.525 168.538 1.00 70.37 ? 161 ARG A CG  1 
ATOM   2929 C CD  . ARG C 3 161 ? 214.249 244.678 168.655 1.00 70.37 ? 161 ARG A CD  1 
ATOM   2930 N NE  . ARG C 3 161 ? 214.846 244.748 169.983 1.00 70.37 ? 161 ARG A NE  1 
ATOM   2931 C CZ  . ARG C 3 161 ? 216.065 244.319 170.281 1.00 70.37 ? 161 ARG A CZ  1 
ATOM   2932 N NH1 . ARG C 3 161 ? 216.855 243.788 169.362 1.00 70.37 ? 161 ARG A NH1 1 
ATOM   2933 N NH2 . ARG C 3 161 ? 216.502 244.424 171.532 1.00 70.37 ? 161 ARG A NH2 1 
ATOM   2934 N N   . ASN C 3 162 ? 209.049 242.844 170.477 1.00 72.90 ? 162 ASN A N   1 
ATOM   2935 C CA  . ASN C 3 162 ? 207.938 243.108 171.385 1.00 72.90 ? 162 ASN A CA  1 
ATOM   2936 C C   . ASN C 3 162 ? 207.046 241.880 171.548 1.00 72.90 ? 162 ASN A C   1 
ATOM   2937 O O   . ASN C 3 162 ? 205.828 241.992 171.703 1.00 72.90 ? 162 ASN A O   1 
ATOM   2938 C CB  . ASN C 3 162 ? 207.117 244.299 170.900 1.00 72.90 ? 162 ASN A CB  1 
ATOM   2939 C CG  . ASN C 3 162 ? 207.915 245.583 170.874 1.00 72.90 ? 162 ASN A CG  1 
ATOM   2940 O OD1 . ASN C 3 162 ? 208.948 245.671 170.212 1.00 72.90 ? 162 ASN A OD1 1 
ATOM   2941 N ND2 . ASN C 3 162 ? 207.436 246.591 171.588 1.00 72.90 ? 162 ASN A ND2 1 
ATOM   2942 N N   . SER C 3 163 ? 207.645 240.692 171.515 1.00 61.42 ? 163 SER A N   1 
ATOM   2943 C CA  . SER C 3 163 ? 206.887 239.457 171.664 1.00 61.42 ? 163 SER A CA  1 
ATOM   2944 C C   . SER C 3 163 ? 207.596 238.507 172.616 1.00 61.42 ? 163 SER A C   1 
ATOM   2945 O O   . SER C 3 163 ? 208.581 238.885 173.256 1.00 61.42 ? 163 SER A O   1 
ATOM   2946 C CB  . SER C 3 163 ? 206.678 238.792 170.306 1.00 61.42 ? 163 SER A CB  1 
ATOM   2947 O OG  . SER C 3 163 ? 207.848 238.111 169.893 1.00 61.42 ? 163 SER A OG  1 
ATOM   2948 N N   . VAL C 3 164 ? 207.095 237.278 172.719 1.00 54.01 ? 164 VAL A N   1 
ATOM   2949 C CA  . VAL C 3 164 ? 207.710 236.242 173.538 1.00 54.01 ? 164 VAL A CA  1 
ATOM   2950 C C   . VAL C 3 164 ? 207.093 234.901 173.167 1.00 54.01 ? 164 VAL A C   1 
ATOM   2951 O O   . VAL C 3 164 ? 205.921 234.833 172.784 1.00 54.01 ? 164 VAL A O   1 
ATOM   2952 C CB  . VAL C 3 164 ? 207.540 236.545 175.036 1.00 54.01 ? 164 VAL A CB  1 
ATOM   2953 C CG1 . VAL C 3 164 ? 206.083 236.616 175.393 1.00 54.01 ? 164 VAL A CG1 1 
ATOM   2954 C CG2 . VAL C 3 164 ? 208.256 235.510 175.887 1.00 54.01 ? 164 VAL A CG2 1 
ATOM   2955 N N   . ARG C 3 165 ? 207.877 233.831 173.252 1.00 53.18 ? 165 ARG A N   1 
ATOM   2956 C CA  . ARG C 3 165 ? 207.360 232.490 173.027 1.00 53.18 ? 165 ARG A CA  1 
ATOM   2957 C C   . ARG C 3 165 ? 208.144 231.501 173.877 1.00 53.18 ? 165 ARG A C   1 
ATOM   2958 O O   . ARG C 3 165 ? 209.372 231.573 173.954 1.00 53.18 ? 165 ARG A O   1 
ATOM   2959 C CB  . ARG C 3 165 ? 207.435 232.101 171.549 1.00 53.18 ? 165 ARG A CB  1 
ATOM   2960 C CG  . ARG C 3 165 ? 208.816 232.243 170.942 1.00 53.18 ? 165 ARG A CG  1 
ATOM   2961 C CD  . ARG C 3 165 ? 208.781 232.119 169.436 1.00 53.18 ? 165 ARG A CD  1 
ATOM   2962 N NE  . ARG C 3 165 ? 207.682 232.866 168.841 1.00 53.18 ? 165 ARG A NE  1 
ATOM   2963 C CZ  . ARG C 3 165 ? 206.884 232.392 167.895 1.00 53.18 ? 165 ARG A CZ  1 
ATOM   2964 N NH1 . ARG C 3 165 ? 207.026 231.164 167.423 1.00 53.18 ? 165 ARG A NH1 1 
ATOM   2965 N NH2 . ARG C 3 165 ? 205.922 233.169 167.406 1.00 53.18 ? 165 ARG A NH2 1 
ATOM   2966 N N   . LEU C 3 166 ? 207.426 230.586 174.521 1.00 53.32 ? 166 LEU A N   1 
ATOM   2967 C CA  . LEU C 3 166 ? 208.027 229.576 175.379 1.00 53.32 ? 166 LEU A CA  1 
ATOM   2968 C C   . LEU C 3 166 ? 207.641 228.196 174.867 1.00 53.32 ? 166 LEU A C   1 
ATOM   2969 O O   . LEU C 3 166 ? 206.794 228.052 173.983 1.00 53.32 ? 166 LEU A O   1 
ATOM   2970 C CB  . LEU C 3 166 ? 207.587 229.735 176.840 1.00 53.32 ? 166 LEU A CB  1 
ATOM   2971 C CG  . LEU C 3 166 ? 207.360 231.130 177.419 1.00 53.32 ? 166 LEU A CG  1 
ATOM   2972 C CD1 . LEU C 3 166 ? 207.160 231.028 178.912 1.00 53.32 ? 166 LEU A CD1 1 
ATOM   2973 C CD2 . LEU C 3 166 ? 208.538 232.038 177.137 1.00 53.32 ? 166 LEU A CD2 1 
ATOM   2974 N N   . VAL C 3 167 ? 208.275 227.171 175.429 1.00 53.11 ? 167 VAL A N   1 
ATOM   2975 C CA  . VAL C 3 167 ? 207.999 225.785 175.073 1.00 53.11 ? 167 VAL A CA  1 
ATOM   2976 C C   . VAL C 3 167 ? 207.665 225.017 176.341 1.00 53.11 ? 167 VAL A C   1 
ATOM   2977 O O   . VAL C 3 167 ? 208.387 225.116 177.339 1.00 53.11 ? 167 VAL A O   1 
ATOM   2978 C CB  . VAL C 3 167 ? 209.187 225.138 174.341 1.00 53.11 ? 167 VAL A CB  1 
ATOM   2979 C CG1 . VAL C 3 167 ? 208.823 223.739 173.879 1.00 53.11 ? 167 VAL A CG1 1 
ATOM   2980 C CG2 . VAL C 3 167 ? 209.614 225.995 173.168 1.00 53.11 ? 167 VAL A CG2 1 
ATOM   2981 N N   . ILE C 3 168 ? 206.573 224.256 176.303 1.00 55.69 ? 168 ILE A N   1 
ATOM   2982 C CA  . ILE C 3 168 ? 206.166 223.410 177.413 1.00 55.69 ? 168 ILE A CA  1 
ATOM   2983 C C   . ILE C 3 168 ? 205.956 222.002 176.878 1.00 55.69 ? 168 ILE A C   1 
ATOM   2984 O O   . ILE C 3 168 ? 205.744 221.794 175.683 1.00 55.69 ? 168 ILE A O   1 
ATOM   2985 C CB  . ILE C 3 168 ? 204.891 223.924 178.108 1.00 55.69 ? 168 ILE A CB  1 
ATOM   2986 C CG1 . ILE C 3 168 ? 203.737 223.992 177.112 1.00 55.69 ? 168 ILE A CG1 1 
ATOM   2987 C CG2 . ILE C 3 168 ? 205.136 225.282 178.723 1.00 55.69 ? 168 ILE A CG2 1 
ATOM   2988 C CD1 . ILE C 3 168 ? 202.396 224.256 177.752 1.00 55.69 ? 168 ILE A CD1 1 
ATOM   2989 N N   . ARG C 3 169 ? 206.014 221.027 177.778 1.00 61.28 ? 169 ARG A N   1 
ATOM   2990 C CA  . ARG C 3 169 ? 205.960 219.624 177.398 1.00 61.28 ? 169 ARG A CA  1 
ATOM   2991 C C   . ARG C 3 169 ? 204.832 218.911 178.129 1.00 61.28 ? 169 ARG A C   1 
ATOM   2992 O O   . ARG C 3 169 ? 204.592 219.157 179.314 1.00 61.28 ? 169 ARG A O   1 
ATOM   2993 C CB  . ARG C 3 169 ? 207.292 218.934 177.687 1.00 61.28 ? 169 ARG A CB  1 
ATOM   2994 C CG  . ARG C 3 169 ? 208.438 219.458 176.843 1.00 61.28 ? 169 ARG A CG  1 
ATOM   2995 C CD  . ARG C 3 169 ? 209.652 218.558 176.945 1.00 61.28 ? 169 ARG A CD  1 
ATOM   2996 N NE  . ARG C 3 169 ? 209.979 218.249 178.330 1.00 61.28 ? 169 ARG A NE  1 
ATOM   2997 C CZ  . ARG C 3 169 ? 210.198 217.026 178.787 1.00 61.28 ? 169 ARG A CZ  1 
ATOM   2998 N NH1 . ARG C 3 169 ? 210.125 215.970 177.995 1.00 61.28 ? 169 ARG A NH1 1 
ATOM   2999 N NH2 . ARG C 3 169 ? 210.496 216.857 180.071 1.00 61.28 ? 169 ARG A NH2 1 
ATOM   3000 N N   . LYS C 3 170 ? 204.142 218.027 177.412 1.00 58.98 ? 170 LYS A N   1 
ATOM   3001 C CA  . LYS C 3 170 ? 203.032 217.257 177.972 1.00 58.98 ? 170 LYS A CA  1 
ATOM   3002 C C   . LYS C 3 170 ? 203.507 215.863 178.377 1.00 58.98 ? 170 LYS A C   1 
ATOM   3003 O O   . LYS C 3 170 ? 203.112 214.846 177.813 1.00 58.98 ? 170 LYS A O   1 
ATOM   3004 C CB  . LYS C 3 170 ? 201.889 217.180 176.968 1.00 58.98 ? 170 LYS A CB  1 
ATOM   3005 C CG  . LYS C 3 170 ? 200.523 217.059 177.600 1.00 58.98 ? 170 LYS A CG  1 
ATOM   3006 C CD  . LYS C 3 170 ? 199.425 217.037 176.555 1.00 58.98 ? 170 LYS A CD  1 
ATOM   3007 C CE  . LYS C 3 170 ? 199.834 216.237 175.333 1.00 58.98 ? 170 LYS A CE  1 
ATOM   3008 N NZ  . LYS C 3 170 ? 199.669 214.776 175.559 1.00 58.98 ? 170 LYS A NZ  1 
ATOM   3009 N N   . VAL C 3 171 ? 204.369 215.832 179.394 1.00 57.13 ? 171 VAL A N   1 
ATOM   3010 C CA  . VAL C 3 171 ? 204.885 214.567 179.896 1.00 57.13 ? 171 VAL A CA  1 
ATOM   3011 C C   . VAL C 3 171 ? 203.745 213.749 180.492 1.00 57.13 ? 171 VAL A C   1 
ATOM   3012 O O   . VAL C 3 171 ? 202.711 214.287 180.909 1.00 57.13 ? 171 VAL A O   1 
ATOM   3013 C CB  . VAL C 3 171 ? 205.997 214.826 180.930 1.00 57.13 ? 171 VAL A CB  1 
ATOM   3014 C CG1 . VAL C 3 171 ? 205.433 215.520 182.159 1.00 57.13 ? 171 VAL A CG1 1 
ATOM   3015 C CG2 . VAL C 3 171 ? 206.722 213.541 181.301 1.00 57.13 ? 171 VAL A CG2 1 
ATOM   3016 N N   . GLN C 3 172 ? 203.925 212.431 180.520 1.00 55.18 ? 172 GLN A N   1 
ATOM   3017 C CA  . GLN C 3 172 ? 202.892 211.507 180.969 1.00 55.18 ? 172 GLN A CA  1 
ATOM   3018 C C   . GLN C 3 172 ? 203.559 210.348 181.692 1.00 55.18 ? 172 GLN A C   1 
ATOM   3019 O O   . GLN C 3 172 ? 204.324 209.597 181.082 1.00 55.18 ? 172 GLN A O   1 
ATOM   3020 C CB  . GLN C 3 172 ? 202.067 211.025 179.775 1.00 55.18 ? 172 GLN A CB  1 
ATOM   3021 C CG  . GLN C 3 172 ? 201.337 209.733 179.969 1.00 55.18 ? 172 GLN A CG  1 
ATOM   3022 C CD  . GLN C 3 172 ? 200.775 209.217 178.664 1.00 55.18 ? 172 GLN A CD  1 
ATOM   3023 O OE1 . GLN C 3 172 ? 200.957 208.055 178.311 1.00 55.18 ? 172 GLN A OE1 1 
ATOM   3024 N NE2 . GLN C 3 172 ? 200.095 210.089 177.932 1.00 55.18 ? 172 GLN A NE2 1 
ATOM   3025 N N   . TYR C 3 173 ? 203.271 210.203 182.980 1.00 54.64 ? 173 TYR A N   1 
ATOM   3026 C CA  . TYR C 3 173 ? 204.037 209.336 183.864 1.00 54.64 ? 173 TYR A CA  1 
ATOM   3027 C C   . TYR C 3 173 ? 203.384 207.969 184.023 1.00 54.64 ? 173 TYR A C   1 
ATOM   3028 O O   . TYR C 3 173 ? 202.203 207.774 183.732 1.00 54.64 ? 173 TYR A O   1 
ATOM   3029 C CB  . TYR C 3 173 ? 204.206 209.985 185.239 1.00 54.64 ? 173 TYR A CB  1 
ATOM   3030 C CG  . TYR C 3 173 ? 205.142 211.163 185.242 1.00 54.64 ? 173 TYR A CG  1 
ATOM   3031 C CD1 . TYR C 3 173 ? 206.516 210.982 185.240 1.00 54.64 ? 173 TYR A CD1 1 
ATOM   3032 C CD2 . TYR C 3 173 ? 204.655 212.457 185.241 1.00 54.64 ? 173 TYR A CD2 1 
ATOM   3033 C CE1 . TYR C 3 173 ? 207.376 212.058 185.241 1.00 54.64 ? 173 TYR A CE1 1 
ATOM   3034 C CE2 . TYR C 3 173 ? 205.508 213.536 185.242 1.00 54.64 ? 173 TYR A CE2 1 
ATOM   3035 C CZ  . TYR C 3 173 ? 206.865 213.332 185.242 1.00 54.64 ? 173 TYR A CZ  1 
ATOM   3036 O OH  . TYR C 3 173 ? 207.717 214.409 185.242 1.00 54.64 ? 173 TYR A OH  1 
ATOM   3037 N N   . ALA C 3 174 ? 204.183 207.017 184.508 1.00 57.98 ? 174 ALA A N   1 
ATOM   3038 C CA  . ALA C 3 174 ? 203.768 205.636 184.687 1.00 57.98 ? 174 ALA A CA  1 
ATOM   3039 C C   . ALA C 3 174 ? 202.919 205.475 185.946 1.00 57.98 ? 174 ALA A C   1 
ATOM   3040 O O   . ALA C 3 174 ? 203.067 206.235 186.906 1.00 57.98 ? 174 ALA A O   1 
ATOM   3041 C CB  . ALA C 3 174 ? 204.986 204.725 184.774 1.00 57.98 ? 174 ALA A CB  1 
ATOM   3042 N N   . PRO C 3 175 ? 202.028 204.491 185.967 1.00 64.27 ? 175 PRO A N   1 
ATOM   3043 C CA  . PRO C 3 175 ? 201.206 204.241 187.154 1.00 64.27 ? 175 PRO A CA  1 
ATOM   3044 C C   . PRO C 3 175 ? 202.015 203.541 188.241 1.00 64.27 ? 175 PRO A C   1 
ATOM   3045 O O   . PRO C 3 175 ? 203.178 203.186 188.058 1.00 64.27 ? 175 PRO A O   1 
ATOM   3046 C CB  . PRO C 3 175 ? 200.084 203.347 186.622 1.00 64.27 ? 175 PRO A CB  1 
ATOM   3047 C CG  . PRO C 3 175 ? 200.670 202.672 185.444 1.00 64.27 ? 175 PRO A CG  1 
ATOM   3048 C CD  . PRO C 3 175 ? 201.629 203.643 184.830 1.00 64.27 ? 175 PRO A CD  1 
ATOM   3049 N N   . GLU C 3 176 ? 201.372 203.349 189.390 1.00 67.91 ? 176 GLU A N   1 
ATOM   3050 C CA  . GLU C 3 176 ? 202.038 202.746 190.535 1.00 67.91 ? 176 GLU A CA  1 
ATOM   3051 C C   . GLU C 3 176 ? 202.400 201.292 190.252 1.00 67.91 ? 176 GLU A C   1 
ATOM   3052 O O   . GLU C 3 176 ? 201.692 200.576 189.540 1.00 67.91 ? 176 GLU A O   1 
ATOM   3053 C CB  . GLU C 3 176 ? 201.150 202.830 191.776 1.00 67.91 ? 176 GLU A CB  1 
ATOM   3054 C CG  . GLU C 3 176 ? 200.520 204.193 191.999 1.00 67.91 ? 176 GLU A CG  1 
ATOM   3055 C CD  . GLU C 3 176 ? 201.551 205.283 192.214 1.00 67.91 ? 176 GLU A CD  1 
ATOM   3056 O OE1 . GLU C 3 176 ? 202.571 205.015 192.882 1.00 67.91 ? 176 GLU A OE1 1 
ATOM   3057 O OE2 . GLU C 3 176 ? 201.340 206.409 191.715 1.00 67.91 ? 176 GLU A OE2 1 
ATOM   3058 N N   . ALA C 3 177 ? 203.522 200.861 190.823 1.00 63.78 ? 177 ALA A N   1 
ATOM   3059 C CA  . ALA C 3 177 ? 204.052 199.515 190.641 1.00 63.78 ? 177 ALA A CA  1 
ATOM   3060 C C   . ALA C 3 177 ? 204.338 198.871 191.991 1.00 63.78 ? 177 ALA A C   1 
ATOM   3061 O O   . ALA C 3 177 ? 205.399 198.287 192.222 1.00 63.78 ? 177 ALA A O   1 
ATOM   3062 C CB  . ALA C 3 177 ? 205.308 199.538 189.774 1.00 63.78 ? 177 ALA A CB  1 
ATOM   3063 N N   . ASP C 3 178 ? 203.377 198.983 192.911 1.00 63.07 ? 178 ASP A N   1 
ATOM   3064 C CA  . ASP C 3 178 ? 203.538 198.366 194.223 1.00 63.07 ? 178 ASP A CA  1 
ATOM   3065 C C   . ASP C 3 178 ? 203.639 196.850 194.112 1.00 63.07 ? 178 ASP A C   1 
ATOM   3066 O O   . ASP C 3 178 ? 204.473 196.225 194.778 1.00 63.07 ? 178 ASP A O   1 
ATOM   3067 C CB  . ASP C 3 178 ? 202.376 198.764 195.132 1.00 63.07 ? 178 ASP A CB  1 
ATOM   3068 C CG  . ASP C 3 178 ? 201.036 198.675 194.433 1.00 63.07 ? 178 ASP A CG  1 
ATOM   3069 O OD1 . ASP C 3 178 ? 200.995 198.173 193.290 1.00 63.07 ? 178 ASP A OD1 1 
ATOM   3070 O OD2 . ASP C 3 178 ? 200.024 199.106 195.025 1.00 63.07 ? 178 ASP A OD2 1 
ATOM   3071 N N   . LEU C 3 179 ? 202.798 196.243 193.275 1.00 57.39 ? 179 LEU A N   1 
ATOM   3072 C CA  . LEU C 3 179 ? 202.862 194.799 193.079 1.00 57.39 ? 179 LEU A CA  1 
ATOM   3073 C C   . LEU C 3 179 ? 204.193 194.381 192.470 1.00 57.39 ? 179 LEU A C   1 
ATOM   3074 O O   . LEU C 3 179 ? 204.773 193.360 192.861 1.00 57.39 ? 179 LEU A O   1 
ATOM   3075 C CB  . LEU C 3 179 ? 201.705 194.343 192.195 1.00 57.39 ? 179 LEU A CB  1 
ATOM   3076 C CG  . LEU C 3 179 ? 201.468 192.838 192.154 1.00 57.39 ? 179 LEU A CG  1 
ATOM   3077 C CD1 . LEU C 3 179 ? 199.984 192.537 192.153 1.00 57.39 ? 179 LEU A CD1 1 
ATOM   3078 C CD2 . LEU C 3 179 ? 202.135 192.233 190.934 1.00 57.39 ? 179 LEU A CD2 1 
ATOM   3079 N N   . GLU C 3 180 ? 204.686 195.151 191.500 1.00 59.01 ? 180 GLU A N   1 
ATOM   3080 C CA  . GLU C 3 180 ? 205.974 194.839 190.893 1.00 59.01 ? 180 GLU A CA  1 
ATOM   3081 C C   . GLU C 3 180 ? 207.098 194.938 191.915 1.00 59.01 ? 180 GLU A C   1 
ATOM   3082 O O   . GLU C 3 180 ? 208.001 194.095 191.936 1.00 59.01 ? 180 GLU A O   1 
ATOM   3083 C CB  . GLU C 3 180 ? 206.230 195.769 189.710 1.00 59.01 ? 180 GLU A CB  1 
ATOM   3084 C CG  . GLU C 3 180 ? 205.019 195.962 188.809 1.00 59.01 ? 180 GLU A CG  1 
ATOM   3085 C CD  . GLU C 3 180 ? 204.933 194.925 187.705 1.00 59.01 ? 180 GLU A CD  1 
ATOM   3086 O OE1 . GLU C 3 180 ? 205.393 193.783 187.916 1.00 59.01 ? 180 GLU A OE1 1 
ATOM   3087 O OE2 . GLU C 3 180 ? 204.402 195.252 186.623 1.00 59.01 ? 180 GLU A OE2 1 
ATOM   3088 N N   . ASP C 3 181 ? 207.057 195.959 192.773 1.00 58.81 ? 181 ASP A N   1 
ATOM   3089 C CA  . ASP C 3 181 ? 208.066 196.083 193.820 1.00 58.81 ? 181 ASP A CA  1 
ATOM   3090 C C   . ASP C 3 181 ? 208.000 194.910 194.789 1.00 58.81 ? 181 ASP A C   1 
ATOM   3091 O O   . ASP C 3 181 ? 209.037 194.375 195.206 1.00 58.81 ? 181 ASP A O   1 
ATOM   3092 C CB  . ASP C 3 181 ? 207.889 197.404 194.566 1.00 58.81 ? 181 ASP A CB  1 
ATOM   3093 C CG  . ASP C 3 181 ? 209.056 197.718 195.481 1.00 58.81 ? 181 ASP A CG  1 
ATOM   3094 O OD1 . ASP C 3 181 ? 210.178 197.245 195.200 1.00 58.81 ? 181 ASP A OD1 1 
ATOM   3095 O OD2 . ASP C 3 181 ? 208.853 198.439 196.480 1.00 58.81 ? 181 ASP A OD2 1 
ATOM   3096 N N   . ASN C 3 182 ? 206.787 194.498 195.158 1.00 54.23 ? 182 ASN A N   1 
ATOM   3097 C CA  . ASN C 3 182 ? 206.628 193.361 196.057 1.00 54.23 ? 182 ASN A CA  1 
ATOM   3098 C C   . ASN C 3 182 ? 207.211 192.095 195.443 1.00 54.23 ? 182 ASN A C   1 
ATOM   3099 O O   . ASN C 3 182 ? 207.927 191.336 196.108 1.00 54.23 ? 182 ASN A O   1 
ATOM   3100 C CB  . ASN C 3 182 ? 205.150 193.166 196.390 1.00 54.23 ? 182 ASN A CB  1 
ATOM   3101 C CG  . ASN C 3 182 ? 204.576 194.320 197.176 1.00 54.23 ? 182 ASN A CG  1 
ATOM   3102 O OD1 . ASN C 3 182 ? 205.282 194.984 197.931 1.00 54.23 ? 182 ASN A OD1 1 
ATOM   3103 N ND2 . ASN C 3 182 ? 203.287 194.570 197.000 1.00 54.23 ? 182 ASN A ND2 1 
ATOM   3104 N N   . TRP C 3 183 ? 206.918 191.854 194.165 1.00 53.23 ? 183 TRP A N   1 
ATOM   3105 C CA  . TRP C 3 183 ? 207.444 190.660 193.514 1.00 53.23 ? 183 TRP A CA  1 
ATOM   3106 C C   . TRP C 3 183 ? 208.956 190.731 193.371 1.00 53.23 ? 183 TRP A C   1 
ATOM   3107 O O   . TRP C 3 183 ? 209.640 189.707 193.469 1.00 53.23 ? 183 TRP A O   1 
ATOM   3108 C CB  . TRP C 3 183 ? 206.786 190.457 192.151 1.00 53.23 ? 183 TRP A CB  1 
ATOM   3109 C CG  . TRP C 3 183 ? 205.719 189.409 192.155 1.00 53.23 ? 183 TRP A CG  1 
ATOM   3110 C CD1 . TRP C 3 183 ? 204.420 189.573 191.794 1.00 53.23 ? 183 TRP A CD1 1 
ATOM   3111 C CD2 . TRP C 3 183 ? 205.854 188.041 192.555 1.00 53.23 ? 183 TRP A CD2 1 
ATOM   3112 N NE1 . TRP C 3 183 ? 203.736 188.394 191.937 1.00 53.23 ? 183 TRP A NE1 1 
ATOM   3113 C CE2 . TRP C 3 183 ? 204.595 187.437 192.400 1.00 53.23 ? 183 TRP A CE2 1 
ATOM   3114 C CE3 . TRP C 3 183 ? 206.917 187.268 193.026 1.00 53.23 ? 183 TRP A CE3 1 
ATOM   3115 C CZ2 . TRP C 3 183 ? 204.368 186.100 192.701 1.00 53.23 ? 183 TRP A CZ2 1 
ATOM   3116 C CZ3 . TRP C 3 183 ? 206.690 185.939 193.324 1.00 53.23 ? 183 TRP A CZ3 1 
ATOM   3117 C CH2 . TRP C 3 183 ? 205.426 185.369 193.161 1.00 53.23 ? 183 TRP A CH2 1 
ATOM   3118 N N   . GLU C 3 184 ? 209.498 191.924 193.122 1.00 56.34 ? 184 GLU A N   1 
ATOM   3119 C CA  . GLU C 3 184 ? 210.946 192.064 193.038 1.00 56.34 ? 184 GLU A CA  1 
ATOM   3120 C C   . GLU C 3 184 ? 211.600 191.728 194.370 1.00 56.34 ? 184 GLU A C   1 
ATOM   3121 O O   . GLU C 3 184 ? 212.624 191.032 194.414 1.00 56.34 ? 184 GLU A O   1 
ATOM   3122 C CB  . GLU C 3 184 ? 211.310 193.480 192.594 1.00 56.34 ? 184 GLU A CB  1 
ATOM   3123 C CG  . GLU C 3 184 ? 212.803 193.740 192.499 1.00 56.34 ? 184 GLU A CG  1 
ATOM   3124 C CD  . GLU C 3 184 ? 213.454 192.997 191.347 1.00 56.34 ? 184 GLU A CD  1 
ATOM   3125 O OE1 . GLU C 3 184 ? 212.752 192.694 190.360 1.00 56.34 ? 184 GLU A OE1 1 
ATOM   3126 O OE2 . GLU C 3 184 ? 214.668 192.715 191.430 1.00 56.34 ? 184 GLU A OE2 1 
ATOM   3127 N N   . THR C 3 185 ? 211.010 192.203 195.469 1.00 54.66 ? 185 THR A N   1 
ATOM   3128 C CA  . THR C 3 185 ? 211.506 191.838 196.791 1.00 54.66 ? 185 THR A CA  1 
ATOM   3129 C C   . THR C 3 185 ? 211.445 190.333 196.997 1.00 54.66 ? 185 THR A C   1 
ATOM   3130 O O   . THR C 3 185 ? 212.399 189.726 197.501 1.00 54.66 ? 185 THR A O   1 
ATOM   3131 C CB  . THR C 3 185 ? 210.691 192.546 197.871 1.00 54.66 ? 185 THR A CB  1 
ATOM   3132 O OG1 . THR C 3 185 ? 210.302 193.845 197.408 1.00 54.66 ? 185 THR A OG1 1 
ATOM   3133 C CG2 . THR C 3 185 ? 211.508 192.691 199.142 1.00 54.66 ? 185 THR A CG2 1 
ATOM   3134 N N   . LEU C 3 186 ? 210.327 189.715 196.610 1.00 52.61 ? 186 LEU A N   1 
ATOM   3135 C CA  . LEU C 3 186 ? 210.179 188.274 196.783 1.00 52.61 ? 186 LEU A CA  1 
ATOM   3136 C C   . LEU C 3 186 ? 211.252 187.515 196.017 1.00 52.61 ? 186 LEU A C   1 
ATOM   3137 O O   . LEU C 3 186 ? 211.862 186.579 196.547 1.00 52.61 ? 186 LEU A O   1 
ATOM   3138 C CB  . LEU C 3 186 ? 208.789 187.834 196.331 1.00 52.61 ? 186 LEU A CB  1 
ATOM   3139 C CG  . LEU C 3 186 ? 207.651 187.964 197.343 1.00 52.61 ? 186 LEU A CG  1 
ATOM   3140 C CD1 . LEU C 3 186 ? 206.375 188.390 196.647 1.00 52.61 ? 186 LEU A CD1 1 
ATOM   3141 C CD2 . LEU C 3 186 ? 207.442 186.649 198.057 1.00 52.61 ? 186 LEU A CD2 1 
ATOM   3142 N N   . ASN C 3 187 ? 211.507 187.917 194.772 1.00 54.20 ? 187 ASN A N   1 
ATOM   3143 C CA  . ASN C 3 187 ? 212.489 187.214 193.954 1.00 54.20 ? 187 ASN A CA  1 
ATOM   3144 C C   . ASN C 3 187 ? 213.900 187.393 194.497 1.00 54.20 ? 187 ASN A C   1 
ATOM   3145 O O   . ASN C 3 187 ? 214.675 186.429 194.558 1.00 54.20 ? 187 ASN A O   1 
ATOM   3146 C CB  . ASN C 3 187 ? 212.400 187.699 192.511 1.00 54.20 ? 187 ASN A CB  1 
ATOM   3147 C CG  . ASN C 3 187 ? 211.182 187.165 191.801 1.00 54.20 ? 187 ASN A CG  1 
ATOM   3148 O OD1 . ASN C 3 187 ? 211.150 186.010 191.384 1.00 54.20 ? 187 ASN A OD1 1 
ATOM   3149 N ND2 . ASN C 3 187 ? 210.165 188.005 191.662 1.00 54.20 ? 187 ASN A ND2 1 
ATOM   3150 N N   . ASP C 3 188 ? 214.254 188.616 194.898 1.00 56.16 ? 188 ASP A N   1 
ATOM   3151 C CA  . ASP C 3 188 ? 215.586 188.843 195.446 1.00 56.16 ? 188 ASP A CA  1 
ATOM   3152 C C   . ASP C 3 188 ? 215.796 188.035 196.719 1.00 56.16 ? 188 ASP A C   1 
ATOM   3153 O O   . ASP C 3 188 ? 216.864 187.441 196.922 1.00 56.16 ? 188 ASP A O   1 
ATOM   3154 C CB  . ASP C 3 188 ? 215.795 190.332 195.715 1.00 56.16 ? 188 ASP A CB  1 
ATOM   3155 C CG  . ASP C 3 188 ? 215.661 191.172 194.465 1.00 56.16 ? 188 ASP A CG  1 
ATOM   3156 O OD1 . ASP C 3 188 ? 215.952 190.657 193.366 1.00 56.16 ? 188 ASP A OD1 1 
ATOM   3157 O OD2 . ASP C 3 188 ? 215.264 192.351 194.580 1.00 56.16 ? 188 ASP A OD2 1 
ATOM   3158 N N   . ASN C 3 189 ? 214.788 187.998 197.590 1.00 55.55 ? 189 ASN A N   1 
ATOM   3159 C CA  . ASN C 3 189 ? 214.936 187.249 198.828 1.00 55.55 ? 189 ASN A CA  1 
ATOM   3160 C C   . ASN C 3 189 ? 214.982 185.749 198.573 1.00 55.55 ? 189 ASN A C   1 
ATOM   3161 O O   . ASN C 3 189 ? 215.697 185.028 199.274 1.00 55.55 ? 189 ASN A O   1 
ATOM   3162 C CB  . ASN C 3 189 ? 213.815 187.616 199.791 1.00 55.55 ? 189 ASN A CB  1 
ATOM   3163 C CG  . ASN C 3 189 ? 213.973 189.014 200.342 1.00 55.55 ? 189 ASN A CG  1 
ATOM   3164 O OD1 . ASN C 3 189 ? 214.603 189.218 201.377 1.00 55.55 ? 189 ASN A OD1 1 
ATOM   3165 N ND2 . ASN C 3 189 ? 213.413 189.990 199.642 1.00 55.55 ? 189 ASN A ND2 1 
ATOM   3166 N N   . LEU C 3 190 ? 214.252 185.260 197.571 1.00 54.91 ? 190 LEU A N   1 
ATOM   3167 C CA  . LEU C 3 190 ? 214.378 183.854 197.201 1.00 54.91 ? 190 LEU A CA  1 
ATOM   3168 C C   . LEU C 3 190 ? 215.787 183.541 196.711 1.00 54.91 ? 190 LEU A C   1 
ATOM   3169 O O   . LEU C 3 190 ? 216.352 182.491 197.041 1.00 54.91 ? 190 LEU A O   1 
ATOM   3170 C CB  . LEU C 3 190 ? 213.344 183.499 196.135 1.00 54.91 ? 190 LEU A CB  1 
ATOM   3171 C CG  . LEU C 3 190 ? 213.459 182.109 195.514 1.00 54.91 ? 190 LEU A CG  1 
ATOM   3172 C CD1 . LEU C 3 190 ? 212.793 181.071 196.400 1.00 54.91 ? 190 LEU A CD1 1 
ATOM   3173 C CD2 . LEU C 3 190 ? 212.851 182.099 194.123 1.00 54.91 ? 190 LEU A CD2 1 
ATOM   3174 N N   . LYS C 3 191 ? 216.373 184.444 195.923 1.00 55.08 ? 191 LYS A N   1 
ATOM   3175 C CA  . LYS C 3 191 ? 217.741 184.237 195.456 1.00 55.08 ? 191 LYS A CA  1 
ATOM   3176 C C   . LYS C 3 191 ? 218.721 184.184 196.624 1.00 55.08 ? 191 LYS A C   1 
ATOM   3177 O O   . LYS C 3 191 ? 219.587 183.301 196.687 1.00 55.08 ? 191 LYS A O   1 
ATOM   3178 C CB  . LYS C 3 191 ? 218.133 185.345 194.480 1.00 55.08 ? 191 LYS A CB  1 
ATOM   3179 C CG  . LYS C 3 191 ? 218.419 184.866 193.072 1.00 55.08 ? 191 LYS A CG  1 
ATOM   3180 C CD  . LYS C 3 191 ? 218.420 186.026 192.092 1.00 55.08 ? 191 LYS A CD  1 
ATOM   3181 C CE  . LYS C 3 191 ? 218.408 185.535 190.655 1.00 55.08 ? 191 LYS A CE  1 
ATOM   3182 N NZ  . LYS C 3 191 ? 218.427 186.665 189.685 1.00 55.08 ? 191 LYS A NZ  1 
ATOM   3183 N N   . VAL C 3 192 ? 218.598 185.126 197.565 1.00 55.38 ? 192 VAL A N   1 
ATOM   3184 C CA  . VAL C 3 192 ? 219.534 185.136 198.688 1.00 55.38 ? 192 VAL A CA  1 
ATOM   3185 C C   . VAL C 3 192 ? 219.295 183.930 199.590 1.00 55.38 ? 192 VAL A C   1 
ATOM   3186 O O   . VAL C 3 192 ? 220.218 183.461 200.265 1.00 55.38 ? 192 VAL A O   1 
ATOM   3187 C CB  . VAL C 3 192 ? 219.461 186.465 199.465 1.00 55.38 ? 192 VAL A CB  1 
ATOM   3188 C CG1 . VAL C 3 192 ? 218.182 186.570 200.259 1.00 55.38 ? 192 VAL A CG1 1 
ATOM   3189 C CG2 . VAL C 3 192 ? 220.668 186.616 200.376 1.00 55.38 ? 192 VAL A CG2 1 
ATOM   3190 N N   . ILE C 3 193 ? 218.066 183.407 199.617 1.00 54.33 ? 193 ILE A N   1 
ATOM   3191 C CA  . ILE C 3 193 ? 217.813 182.129 200.276 1.00 54.33 ? 193 ILE A CA  1 
ATOM   3192 C C   . ILE C 3 193 ? 218.597 181.025 199.588 1.00 54.33 ? 193 ILE A C   1 
ATOM   3193 O O   . ILE C 3 193 ? 219.227 180.184 200.241 1.00 54.33 ? 193 ILE A O   1 
ATOM   3194 C CB  . ILE C 3 193 ? 216.305 181.818 200.274 1.00 54.33 ? 193 ILE A CB  1 
ATOM   3195 C CG1 . ILE C 3 193 ? 215.582 182.583 201.379 1.00 54.33 ? 193 ILE A CG1 1 
ATOM   3196 C CG2 . ILE C 3 193 ? 216.069 180.325 200.418 1.00 54.33 ? 193 ILE A CG2 1 
ATOM   3197 C CD1 . ILE C 3 193 ? 215.572 181.879 202.698 1.00 54.33 ? 193 ILE A CD1 1 
ATOM   3198 N N   . GLU C 3 194 ? 218.571 181.014 198.255 1.00 58.32 ? 194 GLU A N   1 
ATOM   3199 C CA  . GLU C 3 194 ? 219.244 179.961 197.502 1.00 58.32 ? 194 GLU A CA  1 
ATOM   3200 C C   . GLU C 3 194 ? 220.754 180.007 197.699 1.00 58.32 ? 194 GLU A C   1 
ATOM   3201 O O   . GLU C 3 194 ? 221.416 178.964 197.711 1.00 58.32 ? 194 GLU A O   1 
ATOM   3202 C CB  . GLU C 3 194 ? 218.898 180.071 196.018 1.00 58.32 ? 194 GLU A CB  1 
ATOM   3203 C CG  . GLU C 3 194 ? 217.533 179.514 195.649 1.00 58.32 ? 194 GLU A CG  1 
ATOM   3204 C CD  . GLU C 3 194 ? 217.554 178.015 195.407 1.00 58.32 ? 194 GLU A CD  1 
ATOM   3205 O OE1 . GLU C 3 194 ? 216.732 177.535 194.599 1.00 58.32 ? 194 GLU A OE1 1 
ATOM   3206 O OE2 . GLU C 3 194 ? 218.391 177.317 196.017 1.00 58.32 ? 194 GLU A OE2 1 
ATOM   3207 N N   . LYS C 3 195 ? 221.318 181.201 197.849 1.00 57.07 ? 195 LYS A N   1 
ATOM   3208 C CA  . LYS C 3 195 ? 222.759 181.349 198.018 1.00 57.07 ? 195 LYS A CA  1 
ATOM   3209 C C   . LYS C 3 195 ? 223.191 181.446 199.480 1.00 57.07 ? 195 LYS A C   1 
ATOM   3210 O O   . LYS C 3 195 ? 224.355 181.758 199.745 1.00 57.07 ? 195 LYS A O   1 
ATOM   3211 C CB  . LYS C 3 195 ? 223.253 182.580 197.257 1.00 57.07 ? 195 LYS A CB  1 
ATOM   3212 C CG  . LYS C 3 195 ? 223.949 182.263 195.947 1.00 57.07 ? 195 LYS A CG  1 
ATOM   3213 C CD  . LYS C 3 195 ? 223.951 183.459 195.004 1.00 57.07 ? 195 LYS A CD  1 
ATOM   3214 C CE  . LYS C 3 195 ? 224.023 184.775 195.759 1.00 57.07 ? 195 LYS A CE  1 
ATOM   3215 N NZ  . LYS C 3 195 ? 224.030 185.941 194.833 1.00 57.07 ? 195 LYS A NZ  1 
ATOM   3216 N N   . ALA C 3 196 ? 222.294 181.180 200.426 1.00 56.41 ? 196 ALA A N   1 
ATOM   3217 C CA  . ALA C 3 196 ? 222.574 181.439 201.830 1.00 56.41 ? 196 ALA A CA  1 
ATOM   3218 C C   . ALA C 3 196 ? 223.609 180.457 202.378 1.00 56.41 ? 196 ALA A C   1 
ATOM   3219 O O   . ALA C 3 196 ? 223.990 179.479 201.731 1.00 56.41 ? 196 ALA A O   1 
ATOM   3220 C CB  . ALA C 3 196 ? 221.290 181.363 202.652 1.00 56.41 ? 196 ALA A CB  1 
ATOM   3221 N N   . ASP C 3 197 ? 224.066 180.740 203.599 1.00 58.87 ? 197 ASP A N   1 
ATOM   3222 C CA  . ASP C 3 197 ? 225.067 179.931 204.287 1.00 58.87 ? 197 ASP A CA  1 
ATOM   3223 C C   . ASP C 3 197 ? 224.536 179.334 205.582 1.00 58.87 ? 197 ASP A C   1 
ATOM   3224 O O   . ASP C 3 197 ? 224.624 178.116 205.776 1.00 58.87 ? 197 ASP A O   1 
ATOM   3225 C CB  . ASP C 3 197 ? 226.316 180.790 204.563 1.00 58.87 ? 197 ASP A CB  1 
ATOM   3226 C CG  . ASP C 3 197 ? 227.424 180.032 205.291 1.00 58.87 ? 197 ASP A CG  1 
ATOM   3227 O OD1 . ASP C 3 197 ? 228.498 180.635 205.497 1.00 58.87 ? 197 ASP A OD1 1 
ATOM   3228 O OD2 . ASP C 3 197 ? 227.262 178.840 205.622 1.00 58.87 ? 197 ASP A OD2 1 
ATOM   3229 N N   . ASN C 3 198 ? 223.981 180.150 206.472 1.00 56.73 ? 198 ASN A N   1 
ATOM   3230 C CA  . ASN C 3 198 ? 223.507 179.691 207.771 1.00 56.73 ? 198 ASN A CA  1 
ATOM   3231 C C   . ASN C 3 198 ? 222.044 180.088 207.960 1.00 56.73 ? 198 ASN A C   1 
ATOM   3232 O O   . ASN C 3 198 ? 221.372 180.537 207.027 1.00 56.73 ? 198 ASN A O   1 
ATOM   3233 C CB  . ASN C 3 198 ? 224.388 180.242 208.890 1.00 56.73 ? 198 ASN A CB  1 
ATOM   3234 C CG  . ASN C 3 198 ? 224.570 181.735 208.798 1.00 56.73 ? 198 ASN A CG  1 
ATOM   3235 O OD1 . ASN C 3 198 ? 223.979 182.387 207.942 1.00 56.73 ? 198 ASN A OD1 1 
ATOM   3236 N ND2 . ASN C 3 198 ? 225.392 182.290 209.681 1.00 56.73 ? 198 ASN A ND2 1 
ATOM   3237 N N   . ALA C 3 199 ? 221.553 179.918 209.189 1.00 53.33 ? 199 ALA A N   1 
ATOM   3238 C CA  . ALA C 3 199 ? 220.124 180.060 209.445 1.00 53.33 ? 199 ALA A CA  1 
ATOM   3239 C C   . ALA C 3 199 ? 219.672 181.515 209.473 1.00 53.33 ? 199 ALA A C   1 
ATOM   3240 O O   . ALA C 3 199 ? 218.540 181.812 209.077 1.00 53.33 ? 199 ALA A O   1 
ATOM   3241 C CB  . ALA C 3 199 ? 219.761 179.375 210.759 1.00 53.33 ? 199 ALA A CB  1 
ATOM   3242 N N   . ALA C 3 200 ? 220.523 182.430 209.941 1.00 53.79 ? 200 ALA A N   1 
ATOM   3243 C CA  . ALA C 3 200 ? 220.084 183.807 210.152 1.00 53.79 ? 200 ALA A CA  1 
ATOM   3244 C C   . ALA C 3 200 ? 219.697 184.489 208.844 1.00 53.79 ? 200 ALA A C   1 
ATOM   3245 O O   . ALA C 3 200 ? 218.673 185.182 208.776 1.00 53.79 ? 200 ALA A O   1 
ATOM   3246 C CB  . ALA C 3 200 ? 221.179 184.600 210.865 1.00 53.79 ? 200 ALA A CB  1 
ATOM   3247 N N   . GLN C 3 201 ? 220.511 184.324 207.800 1.00 54.86 ? 201 GLN A N   1 
ATOM   3248 C CA  . GLN C 3 201 ? 220.192 184.943 206.518 1.00 54.86 ? 201 GLN A CA  1 
ATOM   3249 C C   . GLN C 3 201 ? 218.900 184.377 205.950 1.00 54.86 ? 201 GLN A C   1 
ATOM   3250 O O   . GLN C 3 201 ? 218.073 185.118 205.401 1.00 54.86 ? 201 GLN A O   1 
ATOM   3251 C CB  . GLN C 3 201 ? 221.344 184.744 205.534 1.00 54.86 ? 201 GLN A CB  1 
ATOM   3252 C CG  . GLN C 3 201 ? 222.725 184.887 206.150 1.00 54.86 ? 201 GLN A CG  1 
ATOM   3253 C CD  . GLN C 3 201 ? 223.763 184.022 205.464 1.00 54.86 ? 201 GLN A CD  1 
ATOM   3254 O OE1 . GLN C 3 201 ? 223.556 183.548 204.349 1.00 54.86 ? 201 GLN A OE1 1 
ATOM   3255 N NE2 . GLN C 3 201 ? 224.889 183.814 206.130 1.00 54.86 ? 201 GLN A NE2 1 
ATOM   3256 N N   . VAL C 3 202 ? 218.709 183.065 206.082 1.00 52.99 ? 202 VAL A N   1 
ATOM   3257 C CA  . VAL C 3 202 ? 217.481 182.431 205.615 1.00 52.99 ? 202 VAL A CA  1 
ATOM   3258 C C   . VAL C 3 202 ? 216.277 183.016 206.338 1.00 52.99 ? 202 VAL A C   1 
ATOM   3259 O O   . VAL C 3 202 ? 215.257 183.350 205.721 1.00 52.99 ? 202 VAL A O   1 
ATOM   3260 C CB  . VAL C 3 202 ? 217.571 180.908 205.804 1.00 52.99 ? 202 VAL A CB  1 
ATOM   3261 C CG1 . VAL C 3 202 ? 216.194 180.299 205.898 1.00 52.99 ? 202 VAL A CG1 1 
ATOM   3262 C CG2 . VAL C 3 202 ? 218.356 180.287 204.665 1.00 52.99 ? 202 VAL A CG2 1 
ATOM   3263 N N   . LYS C 3 203 ? 216.386 183.161 207.658 1.00 52.74 ? 203 LYS A N   1 
ATOM   3264 C CA  . LYS C 3 203 ? 215.279 183.693 208.441 1.00 52.74 ? 203 LYS A CA  1 
ATOM   3265 C C   . LYS C 3 203 ? 214.949 185.118 208.026 1.00 52.74 ? 203 LYS A C   1 
ATOM   3266 O O   . LYS C 3 203 ? 213.776 185.474 207.856 1.00 52.74 ? 203 LYS A O   1 
ATOM   3267 C CB  . LYS C 3 203 ? 215.621 183.631 209.927 1.00 52.74 ? 203 LYS A CB  1 
ATOM   3268 C CG  . LYS C 3 203 ? 215.210 182.341 210.601 1.00 52.74 ? 203 LYS A CG  1 
ATOM   3269 C CD  . LYS C 3 203 ? 215.823 182.223 211.984 1.00 52.74 ? 203 LYS A CD  1 
ATOM   3270 C CE  . LYS C 3 203 ? 215.573 183.471 212.814 1.00 52.74 ? 203 LYS A CE  1 
ATOM   3271 N NZ  . LYS C 3 203 ? 214.129 183.828 212.871 1.00 52.74 ? 203 LYS A NZ  1 
ATOM   3272 N N   . ASP C 3 204 ? 215.976 185.954 207.864 1.00 53.80 ? 204 ASP A N   1 
ATOM   3273 C CA  . ASP C 3 204 ? 215.733 187.343 207.495 1.00 53.80 ? 204 ASP A CA  1 
ATOM   3274 C C   . ASP C 3 204 ? 215.083 187.438 206.123 1.00 53.80 ? 204 ASP A C   1 
ATOM   3275 O O   . ASP C 3 204 ? 214.123 188.200 205.927 1.00 53.80 ? 204 ASP A O   1 
ATOM   3276 C CB  . ASP C 3 204 ? 217.042 188.132 207.529 1.00 53.80 ? 204 ASP A CB  1 
ATOM   3277 C CG  . ASP C 3 204 ? 216.982 189.398 206.698 1.00 53.80 ? 204 ASP A CG  1 
ATOM   3278 O OD1 . ASP C 3 204 ? 216.442 190.410 207.192 1.00 53.80 ? 204 ASP A OD1 1 
ATOM   3279 O OD2 . ASP C 3 204 ? 217.476 189.383 205.550 1.00 53.80 ? 204 ASP A OD2 1 
ATOM   3280 N N   . ALA C 3 205 ? 215.582 186.657 205.163 1.00 52.35 ? 205 ALA A N   1 
ATOM   3281 C CA  . ALA C 3 205 ? 215.005 186.682 203.826 1.00 52.35 ? 205 ALA A CA  1 
ATOM   3282 C C   . ALA C 3 205 ? 213.547 186.250 203.856 1.00 52.35 ? 205 ALA A C   1 
ATOM   3283 O O   . ALA C 3 205 ? 212.688 186.885 203.231 1.00 52.35 ? 205 ALA A O   1 
ATOM   3284 C CB  . ALA C 3 205 ? 215.817 185.790 202.891 1.00 52.35 ? 205 ALA A CB  1 
ATOM   3285 N N   . LEU C 3 206 ? 213.248 185.174 204.591 1.00 50.02 ? 206 LEU A N   1 
ATOM   3286 C CA  . LEU C 3 206 ? 211.879 184.675 204.650 1.00 50.02 ? 206 LEU A CA  1 
ATOM   3287 C C   . LEU C 3 206 ? 210.949 185.685 205.304 1.00 50.02 ? 206 LEU A C   1 
ATOM   3288 O O   . LEU C 3 206 ? 209.807 185.856 204.867 1.00 50.02 ? 206 LEU A O   1 
ATOM   3289 C CB  . LEU C 3 206 ? 211.837 183.345 205.395 1.00 50.02 ? 206 LEU A CB  1 
ATOM   3290 C CG  . LEU C 3 206 ? 212.284 182.135 204.583 1.00 50.02 ? 206 LEU A CG  1 
ATOM   3291 C CD1 . LEU C 3 206 ? 212.612 180.969 205.494 1.00 50.02 ? 206 LEU A CD1 1 
ATOM   3292 C CD2 . LEU C 3 206 ? 211.209 181.750 203.588 1.00 50.02 ? 206 LEU A CD2 1 
ATOM   3293 N N   . THR C 3 207 ? 211.415 186.363 206.356 1.00 49.28 ? 207 THR A N   1 
ATOM   3294 C CA  . THR C 3 207 ? 210.602 187.403 206.979 1.00 49.28 ? 207 THR A CA  1 
ATOM   3295 C C   . THR C 3 207 ? 210.287 188.511 205.984 1.00 49.28 ? 207 THR A C   1 
ATOM   3296 O O   . THR C 3 207 ? 209.135 188.964 205.870 1.00 49.28 ? 207 THR A O   1 
ATOM   3297 C CB  . THR C 3 207 ? 211.327 187.974 208.196 1.00 49.28 ? 207 THR A CB  1 
ATOM   3298 O OG1 . THR C 3 207 ? 211.508 186.943 209.172 1.00 49.28 ? 207 THR A OG1 1 
ATOM   3299 C CG2 . THR C 3 207 ? 210.525 189.101 208.808 1.00 49.28 ? 207 THR A CG2 1 
ATOM   3300 N N   . LYS C 3 208 ? 211.305 188.950 205.240 1.00 50.22 ? 208 LYS A N   1 
ATOM   3301 C CA  . LYS C 3 208 ? 211.092 190.014 204.268 1.00 50.22 ? 208 LYS A CA  1 
ATOM   3302 C C   . LYS C 3 208 ? 210.076 189.600 203.213 1.00 50.22 ? 208 LYS A C   1 
ATOM   3303 O O   . LYS C 3 208 ? 209.161 190.369 202.884 1.00 50.22 ? 208 LYS A O   1 
ATOM   3304 C CB  . LYS C 3 208 ? 212.416 190.404 203.618 1.00 50.22 ? 208 LYS A CB  1 
ATOM   3305 C CG  . LYS C 3 208 ? 213.397 191.061 204.570 1.00 50.22 ? 208 LYS A CG  1 
ATOM   3306 C CD  . LYS C 3 208 ? 214.252 192.089 203.855 1.00 50.22 ? 208 LYS A CD  1 
ATOM   3307 C CE  . LYS C 3 208 ? 215.641 192.154 204.456 1.00 50.22 ? 208 LYS A CE  1 
ATOM   3308 N NZ  . LYS C 3 208 ? 215.597 192.324 205.932 1.00 50.22 ? 208 LYS A NZ  1 
ATOM   3309 N N   . MET C 3 209 ? 210.193 188.379 202.687 1.00 51.11 ? 209 MET A N   1 
ATOM   3310 C CA  . MET C 3 209 ? 209.267 188.005 201.624 1.00 51.11 ? 209 MET A CA  1 
ATOM   3311 C C   . MET C 3 209 ? 207.875 187.720 202.168 1.00 51.11 ? 209 MET A C   1 
ATOM   3312 O O   . MET C 3 209 ? 206.893 187.889 201.444 1.00 51.11 ? 209 MET A O   1 
ATOM   3313 C CB  . MET C 3 209 ? 209.769 186.805 200.821 1.00 51.11 ? 209 MET A CB  1 
ATOM   3314 C CG  . MET C 3 209 ? 210.546 185.777 201.574 1.00 51.11 ? 209 MET A CG  1 
ATOM   3315 S SD  . MET C 3 209 ? 211.460 184.712 200.449 1.00 51.11 ? 209 MET A SD  1 
ATOM   3316 C CE  . MET C 3 209 ? 210.126 184.110 199.424 1.00 51.11 ? 209 MET A CE  1 
ATOM   3317 N N   . ARG C 3 210 ? 207.760 187.291 203.426 1.00 45.36 ? 210 ARG A N   1 
ATOM   3318 C CA  . ARG C 3 210 ? 206.439 187.124 204.024 1.00 45.36 ? 210 ARG A CA  1 
ATOM   3319 C C   . ARG C 3 210 ? 205.723 188.461 204.118 1.00 45.36 ? 210 ARG A C   1 
ATOM   3320 O O   . ARG C 3 210 ? 204.540 188.580 203.761 1.00 45.36 ? 210 ARG A O   1 
ATOM   3321 C CB  . ARG C 3 210 ? 206.569 186.480 205.402 1.00 45.36 ? 210 ARG A CB  1 
ATOM   3322 C CG  . ARG C 3 210 ? 205.328 186.575 206.258 1.00 45.36 ? 210 ARG A CG  1 
ATOM   3323 C CD  . ARG C 3 210 ? 204.621 185.242 206.332 1.00 45.36 ? 210 ARG A CD  1 
ATOM   3324 N NE  . ARG C 3 210 ? 203.469 185.279 207.221 1.00 45.36 ? 210 ARG A NE  1 
ATOM   3325 C CZ  . ARG C 3 210 ? 202.716 184.227 207.505 1.00 45.36 ? 210 ARG A CZ  1 
ATOM   3326 N NH1 . ARG C 3 210 ? 202.975 183.036 206.994 1.00 45.36 ? 210 ARG A NH1 1 
ATOM   3327 N NH2 . ARG C 3 210 ? 201.675 184.374 208.317 1.00 45.36 ? 210 ARG A NH2 1 
ATOM   3328 N N   . ALA C 3 211 ? 206.439 189.492 204.575 1.00 47.35 ? 211 ALA A N   1 
ATOM   3329 C CA  . ALA C 3 211 ? 205.850 190.827 204.604 1.00 47.35 ? 211 ALA A CA  1 
ATOM   3330 C C   . ALA C 3 211 ? 205.465 191.288 203.203 1.00 47.35 ? 211 ALA A C   1 
ATOM   3331 O O   . ALA C 3 211 ? 204.370 191.832 202.994 1.00 47.35 ? 211 ALA A O   1 
ATOM   3332 C CB  . ALA C 3 211 ? 206.820 191.816 205.246 1.00 47.35 ? 211 ALA A CB  1 
ATOM   3333 N N   . ALA C 3 212 ? 206.347 191.060 202.226 1.00 49.12 ? 212 ALA A N   1 
ATOM   3334 C CA  . ALA C 3 212 ? 206.054 191.481 200.859 1.00 49.12 ? 212 ALA A CA  1 
ATOM   3335 C C   . ALA C 3 212 ? 204.825 190.771 200.306 1.00 49.12 ? 212 ALA A C   1 
ATOM   3336 O O   . ALA C 3 212 ? 203.988 191.394 199.646 1.00 49.12 ? 212 ALA A O   1 
ATOM   3337 C CB  . ALA C 3 212 ? 207.265 191.229 199.963 1.00 49.12 ? 212 ALA A CB  1 
ATOM   3338 N N   . ALA C 3 213 ? 204.704 189.466 200.552 1.00 48.01 ? 213 ALA A N   1 
ATOM   3339 C CA  . ALA C 3 213 ? 203.571 188.706 200.037 1.00 48.01 ? 213 ALA A CA  1 
ATOM   3340 C C   . ALA C 3 213 ? 202.264 189.167 200.659 1.00 48.01 ? 213 ALA A C   1 
ATOM   3341 O O   . ALA C 3 213 ? 201.251 189.310 199.960 1.00 48.01 ? 213 ALA A O   1 
ATOM   3342 C CB  . ALA C 3 213 ? 203.780 187.216 200.291 1.00 48.01 ? 213 ALA A CB  1 
ATOM   3343 N N   . LEU C 3 214 ? 202.258 189.389 201.975 1.00 45.92 ? 214 LEU A N   1 
ATOM   3344 C CA  . LEU C 3 214 ? 201.043 189.881 202.609 1.00 45.92 ? 214 LEU A CA  1 
ATOM   3345 C C   . LEU C 3 214 ? 200.652 191.240 202.052 1.00 45.92 ? 214 LEU A C   1 
ATOM   3346 O O   . LEU C 3 214 ? 199.467 191.509 201.830 1.00 45.92 ? 214 LEU A O   1 
ATOM   3347 C CB  . LEU C 3 214 ? 201.222 189.956 204.120 1.00 45.92 ? 214 LEU A CB  1 
ATOM   3348 C CG  . LEU C 3 214 ? 201.020 188.681 204.925 1.00 45.92 ? 214 LEU A CG  1 
ATOM   3349 C CD1 . LEU C 3 214 ? 201.114 189.011 206.393 1.00 45.92 ? 214 LEU A CD1 1 
ATOM   3350 C CD2 . LEU C 3 214 ? 199.686 188.063 204.595 1.00 45.92 ? 214 LEU A CD2 1 
ATOM   3351 N N   . ASP C 3 215 ? 201.634 192.116 201.826 1.00 49.34 ? 215 ASP A N   1 
ATOM   3352 C CA  . ASP C 3 215 ? 201.332 193.414 201.229 1.00 49.34 ? 215 ASP A CA  1 
ATOM   3353 C C   . ASP C 3 215 ? 200.755 193.234 199.830 1.00 49.34 ? 215 ASP A C   1 
ATOM   3354 O O   . ASP C 3 215 ? 199.756 193.868 199.473 1.00 49.34 ? 215 ASP A O   1 
ATOM   3355 C CB  . ASP C 3 215 ? 202.606 194.269 201.212 1.00 49.34 ? 215 ASP A CB  1 
ATOM   3356 C CG  . ASP C 3 215 ? 202.446 195.608 200.487 1.00 49.34 ? 215 ASP A CG  1 
ATOM   3357 O OD1 . ASP C 3 215 ? 203.389 196.422 200.584 1.00 49.34 ? 215 ASP A OD1 1 
ATOM   3358 O OD2 . ASP C 3 215 ? 201.403 195.893 199.869 1.00 49.34 ? 215 ASP A OD2 1 
ATOM   3359 N N   . ALA C 3 216 ? 201.349 192.341 199.037 1.00 49.10 ? 216 ALA A N   1 
ATOM   3360 C CA  . ALA C 3 216 ? 200.942 192.180 197.647 1.00 49.10 ? 216 ALA A CA  1 
ATOM   3361 C C   . ALA C 3 216 ? 199.541 191.608 197.524 1.00 49.10 ? 216 ALA A C   1 
ATOM   3362 O O   . ALA C 3 216 ? 198.821 191.943 196.578 1.00 49.10 ? 216 ALA A O   1 
ATOM   3363 C CB  . ALA C 3 216 ? 201.940 191.289 196.909 1.00 49.10 ? 216 ALA A CB  1 
ATOM   3364 N N   . GLN C 3 217 ? 199.139 190.743 198.454 1.00 47.41 ? 217 GLN A N   1 
ATOM   3365 C CA  . GLN C 3 217 ? 197.810 190.146 198.370 1.00 47.41 ? 217 GLN A CA  1 
ATOM   3366 C C   . GLN C 3 217 ? 196.708 191.198 198.373 1.00 47.41 ? 217 GLN A C   1 
ATOM   3367 O O   . GLN C 3 217 ? 195.645 190.982 197.781 1.00 47.41 ? 217 GLN A O   1 
ATOM   3368 C CB  . GLN C 3 217 ? 197.602 189.166 199.518 1.00 47.41 ? 217 GLN A CB  1 
ATOM   3369 C CG  . GLN C 3 217 ? 196.301 188.397 199.446 1.00 47.41 ? 217 GLN A CG  1 
ATOM   3370 C CD  . GLN C 3 217 ? 196.106 187.500 200.641 1.00 47.41 ? 217 GLN A CD  1 
ATOM   3371 O OE1 . GLN C 3 217 ? 196.301 187.918 201.779 1.00 47.41 ? 217 GLN A OE1 1 
ATOM   3372 N NE2 . GLN C 3 217 ? 195.714 186.260 200.393 1.00 47.41 ? 217 GLN A NE2 1 
ATOM   3373 N N   . LYS C 3 218 ? 196.937 192.336 199.029 1.00 48.60 ? 218 LYS A N   1 
ATOM   3374 C CA  . LYS C 3 218 ? 195.925 193.387 199.059 1.00 48.60 ? 218 LYS A CA  1 
ATOM   3375 C C   . LYS C 3 218 ? 195.719 194.011 197.684 1.00 48.60 ? 218 LYS A C   1 
ATOM   3376 O O   . LYS C 3 218 ? 194.582 194.294 197.291 1.00 48.60 ? 218 LYS A O   1 
ATOM   3377 C CB  . LYS C 3 218 ? 196.317 194.459 200.072 1.00 48.60 ? 218 LYS A CB  1 
ATOM   3378 C CG  . LYS C 3 218 ? 196.108 194.053 201.515 1.00 48.60 ? 218 LYS A CG  1 
ATOM   3379 C CD  . LYS C 3 218 ? 196.715 195.068 202.458 1.00 48.60 ? 218 LYS A CD  1 
ATOM   3380 C CE  . LYS C 3 218 ? 196.160 194.908 203.856 1.00 48.60 ? 218 LYS A CE  1 
ATOM   3381 N NZ  . LYS C 3 218 ? 196.302 193.506 204.337 1.00 48.60 ? 218 LYS A NZ  1 
ATOM   3382 N N   . ALA C 3 219 ? 196.799 194.227 196.939 1.00 53.35 ? 219 ALA A N   1 
ATOM   3383 C CA  . ALA C 3 219 ? 196.733 195.003 195.710 1.00 53.35 ? 219 ALA A CA  1 
ATOM   3384 C C   . ALA C 3 219 ? 195.952 194.264 194.631 1.00 53.35 ? 219 ALA A C   1 
ATOM   3385 O O   . ALA C 3 219 ? 195.753 193.048 194.687 1.00 53.35 ? 219 ALA A O   1 
ATOM   3386 C CB  . ALA C 3 219 ? 198.138 195.324 195.202 1.00 53.35 ? 219 ALA A CB  1 
ATOM   3387 N N   . THR C 3 220 ? 195.501 195.028 193.631 1.00 57.01 ? 220 THR A N   1 
ATOM   3388 C CA  . THR C 3 220 ? 194.734 194.492 192.520 1.00 57.01 ? 220 THR A CA  1 
ATOM   3389 C C   . THR C 3 220 ? 195.551 194.513 191.235 1.00 57.01 ? 220 THR A C   1 
ATOM   3390 O O   . THR C 3 220 ? 196.235 195.501 190.949 1.00 57.01 ? 220 THR A O   1 
ATOM   3391 C CB  . THR C 3 220 ? 193.437 195.279 192.302 1.00 57.01 ? 220 THR A CB  1 
ATOM   3392 O OG1 . THR C 3 220 ? 192.876 194.933 191.030 1.00 57.01 ? 220 THR A OG1 1 
ATOM   3393 C CG2 . THR C 3 220 ? 193.698 196.777 192.354 1.00 57.01 ? 220 THR A CG2 1 
ATOM   3394 N N   . PRO C 3 221 ? 195.508 193.440 190.454 1.00 57.29 ? 221 PRO A N   1 
ATOM   3395 C CA  . PRO C 3 221 ? 196.297 193.381 189.223 1.00 57.29 ? 221 PRO A CA  1 
ATOM   3396 C C   . PRO C 3 221 ? 195.699 194.272 188.151 1.00 57.29 ? 221 PRO A C   1 
ATOM   3397 O O   . PRO C 3 221 ? 194.489 194.545 188.161 1.00 57.29 ? 221 PRO A O   1 
ATOM   3398 C CB  . PRO C 3 221 ? 196.215 191.901 188.830 1.00 57.29 ? 221 PRO A CB  1 
ATOM   3399 C CG  . PRO C 3 221 ? 194.918 191.453 189.389 1.00 57.29 ? 221 PRO A CG  1 
ATOM   3400 C CD  . PRO C 3 221 ? 194.712 192.222 190.662 1.00 57.29 ? 221 PRO A CD  1 
ATOM   3401 N N   . PRO C 3 222 ? 196.514 194.748 187.207 1.00 61.50 ? 222 PRO A N   1 
ATOM   3402 C CA  . PRO C 3 222 ? 195.990 195.656 186.175 1.00 61.50 ? 222 PRO A CA  1 
ATOM   3403 C C   . PRO C 3 222 ? 194.965 195.019 185.257 1.00 61.50 ? 222 PRO A C   1 
ATOM   3404 O O   . PRO C 3 222 ? 194.206 195.747 184.606 1.00 61.50 ? 222 PRO A O   1 
ATOM   3405 C CB  . PRO C 3 222 ? 197.248 196.070 185.398 1.00 61.50 ? 222 PRO A CB  1 
ATOM   3406 C CG  . PRO C 3 222 ? 198.394 195.753 186.309 1.00 61.50 ? 222 PRO A CG  1 
ATOM   3407 C CD  . PRO C 3 222 ? 197.966 194.552 187.084 1.00 61.50 ? 222 PRO A CD  1 
ATOM   3408 N N   . LYS C 3 223 ? 194.915 193.693 185.177 1.00 62.07 ? 223 LYS A N   1 
ATOM   3409 C CA  . LYS C 3 223 ? 194.030 193.021 184.236 1.00 62.07 ? 223 LYS A CA  1 
ATOM   3410 C C   . LYS C 3 223 ? 192.612 192.846 184.762 1.00 62.07 ? 223 LYS A C   1 
ATOM   3411 O O   . LYS C 3 223 ? 191.761 192.330 184.031 1.00 62.07 ? 223 LYS A O   1 
ATOM   3412 C CB  . LYS C 3 223 ? 194.610 191.656 183.862 1.00 62.07 ? 223 LYS A CB  1 
ATOM   3413 C CG  . LYS C 3 223 ? 195.707 191.716 182.818 1.00 62.07 ? 223 LYS A CG  1 
ATOM   3414 C CD  . LYS C 3 223 ? 195.527 190.631 181.769 1.00 62.07 ? 223 LYS A CD  1 
ATOM   3415 C CE  . LYS C 3 223 ? 196.840 190.315 181.072 1.00 62.07 ? 223 LYS A CE  1 
ATOM   3416 N NZ  . LYS C 3 223 ? 197.103 188.850 181.022 1.00 62.07 ? 223 LYS A NZ  1 
ATOM   3417 N N   . LEU C 3 224 ? 192.333 193.252 185.999 1.00 64.62 ? 224 LEU A N   1 
ATOM   3418 C CA  . LEU C 3 224 ? 191.010 193.083 186.588 1.00 64.62 ? 224 LEU A CA  1 
ATOM   3419 C C   . LEU C 3 224 ? 190.490 194.395 187.163 1.00 64.62 ? 224 LEU A C   1 
ATOM   3420 O O   . LEU C 3 224 ? 189.678 194.393 188.092 1.00 64.62 ? 224 LEU A O   1 
ATOM   3421 C CB  . LEU C 3 224 ? 191.028 191.997 187.662 1.00 64.62 ? 224 LEU A CB  1 
ATOM   3422 C CG  . LEU C 3 224 ? 191.635 190.656 187.254 1.00 64.62 ? 224 LEU A CG  1 
ATOM   3423 C CD1 . LEU C 3 224 ? 191.779 189.744 188.456 1.00 64.62 ? 224 LEU A CD1 1 
ATOM   3424 C CD2 . LEU C 3 224 ? 190.787 189.999 186.181 1.00 64.62 ? 224 LEU A CD2 1 
ATOM   3425 N N   . GLU C 3 225 ? 190.947 195.524 186.617 1.00 69.34 ? 225 GLU A N   1 
ATOM   3426 C CA  . GLU C 3 225 ? 190.514 196.820 187.127 1.00 69.34 ? 225 GLU A CA  1 
ATOM   3427 C C   . GLU C 3 225 ? 189.012 197.005 186.963 1.00 69.34 ? 225 GLU A C   1 
ATOM   3428 O O   . GLU C 3 225 ? 188.331 197.472 187.884 1.00 69.34 ? 225 GLU A O   1 
ATOM   3429 C CB  . GLU C 3 225 ? 191.271 197.940 186.417 1.00 69.34 ? 225 GLU A CB  1 
ATOM   3430 C CG  . GLU C 3 225 ? 192.763 197.940 186.679 1.00 69.34 ? 225 GLU A CG  1 
ATOM   3431 C CD  . GLU C 3 225 ? 193.433 199.219 186.220 1.00 69.34 ? 225 GLU A CD  1 
ATOM   3432 O OE1 . GLU C 3 225 ? 192.848 199.927 185.374 1.00 69.34 ? 225 GLU A OE1 1 
ATOM   3433 O OE2 . GLU C 3 225 ? 194.545 199.517 186.705 1.00 69.34 ? 225 GLU A OE2 1 
ATOM   3434 N N   . ASP C 3 226 ? 188.475 196.640 185.797 1.00 71.20 ? 226 ASP A N   1 
ATOM   3435 C CA  . ASP C 3 226 ? 187.042 196.749 185.563 1.00 71.20 ? 226 ASP A CA  1 
ATOM   3436 C C   . ASP C 3 226 ? 186.247 195.644 186.248 1.00 71.20 ? 226 ASP A C   1 
ATOM   3437 O O   . ASP C 3 226 ? 185.030 195.784 186.404 1.00 71.20 ? 226 ASP A O   1 
ATOM   3438 C CB  . ASP C 3 226 ? 186.754 196.744 184.061 1.00 71.20 ? 226 ASP A CB  1 
ATOM   3439 C CG  . ASP C 3 226 ? 187.628 195.768 183.305 1.00 71.20 ? 226 ASP A CG  1 
ATOM   3440 O OD1 . ASP C 3 226 ? 188.762 195.510 183.760 1.00 71.20 ? 226 ASP A OD1 1 
ATOM   3441 O OD2 . ASP C 3 226 ? 187.183 195.259 182.255 1.00 71.20 ? 226 ASP A OD2 1 
ATOM   3442 N N   . LYS C 3 227 ? 186.898 194.560 186.658 1.00 68.07 ? 227 LYS A N   1 
ATOM   3443 C CA  . LYS C 3 227 ? 186.205 193.516 187.396 1.00 68.07 ? 227 LYS A CA  1 
ATOM   3444 C C   . LYS C 3 227 ? 185.915 193.969 188.822 1.00 68.07 ? 227 LYS A C   1 
ATOM   3445 O O   . LYS C 3 227 ? 186.619 194.808 189.389 1.00 68.07 ? 227 LYS A O   1 
ATOM   3446 C CB  . LYS C 3 227 ? 187.022 192.221 187.417 1.00 68.07 ? 227 LYS A CB  1 
ATOM   3447 C CG  . LYS C 3 227 ? 187.360 191.613 186.046 1.00 68.07 ? 227 LYS A CG  1 
ATOM   3448 C CD  . LYS C 3 227 ? 186.180 191.242 185.145 1.00 68.07 ? 227 LYS A CD  1 
ATOM   3449 C CE  . LYS C 3 227 ? 185.380 190.047 185.644 1.00 68.07 ? 227 LYS A CE  1 
ATOM   3450 N NZ  . LYS C 3 227 ? 184.350 189.619 184.657 1.00 68.07 ? 227 LYS A NZ  1 
ATOM   3451 N N   . SER C 3 228 ? 184.865 193.400 189.399 1.00 67.85 ? 228 SER A N   1 
ATOM   3452 C CA  . SER C 3 228 ? 184.388 193.804 190.710 1.00 67.85 ? 228 SER A CA  1 
ATOM   3453 C C   . SER C 3 228 ? 185.255 193.228 191.824 1.00 67.85 ? 228 SER A C   1 
ATOM   3454 O O   . SER C 3 228 ? 185.954 192.231 191.632 1.00 67.85 ? 228 SER A O   1 
ATOM   3455 C CB  . SER C 3 228 ? 182.942 193.359 190.897 1.00 67.85 ? 228 SER A CB  1 
ATOM   3456 O OG  . SER C 3 228 ? 182.869 191.972 191.178 1.00 67.85 ? 228 SER A OG  1 
ATOM   3457 N N   . PRO C 3 229 ? 185.240 193.862 192.998 1.00 66.27 ? 229 PRO A N   1 
ATOM   3458 C CA  . PRO C 3 229 ? 185.949 193.302 194.155 1.00 66.27 ? 229 PRO A CA  1 
ATOM   3459 C C   . PRO C 3 229 ? 185.581 191.866 194.475 1.00 66.27 ? 229 PRO A C   1 
ATOM   3460 O O   . PRO C 3 229 ? 186.445 191.098 194.916 1.00 66.27 ? 229 PRO A O   1 
ATOM   3461 C CB  . PRO C 3 229 ? 185.510 194.236 195.289 1.00 66.27 ? 229 PRO A CB  1 
ATOM   3462 C CG  . PRO C 3 229 ? 185.136 195.552 194.600 1.00 66.27 ? 229 PRO A CG  1 
ATOM   3463 C CD  . PRO C 3 229 ? 185.180 195.327 193.105 1.00 66.27 ? 229 PRO A CD  1 
ATOM   3464 N N   . ASP C 3 230 ? 184.324 191.480 194.280 1.00 68.33 ? 230 ASP A N   1 
ATOM   3465 C CA  . ASP C 3 230 ? 183.857 190.140 194.599 1.00 68.33 ? 230 ASP A CA  1 
ATOM   3466 C C   . ASP C 3 230 ? 183.859 189.210 193.394 1.00 68.33 ? 230 ASP A C   1 
ATOM   3467 O O   . ASP C 3 230 ? 183.288 188.119 193.467 1.00 68.33 ? 230 ASP A O   1 
ATOM   3468 C CB  . ASP C 3 230 ? 182.456 190.208 195.205 1.00 68.33 ? 230 ASP A CB  1 
ATOM   3469 C CG  . ASP C 3 230 ? 182.395 191.106 196.420 1.00 68.33 ? 230 ASP A CG  1 
ATOM   3470 O OD1 . ASP C 3 230 ? 181.293 191.275 196.983 1.00 68.33 ? 230 ASP A OD1 1 
ATOM   3471 O OD2 . ASP C 3 230 ? 183.452 191.644 196.811 1.00 68.33 ? 230 ASP A OD2 1 
ATOM   3472 N N   . SER C 3 231 ? 184.482 189.615 192.292 1.00 66.37 ? 231 SER A N   1 
ATOM   3473 C CA  . SER C 3 231 ? 184.537 188.771 191.112 1.00 66.37 ? 231 SER A CA  1 
ATOM   3474 C C   . SER C 3 231 ? 185.341 187.504 191.398 1.00 66.37 ? 231 SER A C   1 
ATOM   3475 O O   . SER C 3 231 ? 186.283 187.523 192.194 1.00 66.37 ? 231 SER A O   1 
ATOM   3476 C CB  . SER C 3 231 ? 185.164 189.528 189.945 1.00 66.37 ? 231 SER A CB  1 
ATOM   3477 O OG  . SER C 3 231 ? 185.566 188.641 188.916 1.00 66.37 ? 231 SER A OG  1 
ATOM   3478 N N   . PRO C 3 232 ? 184.977 186.382 190.771 1.00 61.97 ? 232 PRO A N   1 
ATOM   3479 C CA  . PRO C 3 232 ? 185.735 185.142 190.995 1.00 61.97 ? 232 PRO A CA  1 
ATOM   3480 C C   . PRO C 3 232 ? 187.195 185.242 190.595 1.00 61.97 ? 232 PRO A C   1 
ATOM   3481 O O   . PRO C 3 232 ? 188.037 184.538 191.172 1.00 61.97 ? 232 PRO A O   1 
ATOM   3482 C CB  . PRO C 3 232 ? 184.982 184.115 190.141 1.00 61.97 ? 232 PRO A CB  1 
ATOM   3483 C CG  . PRO C 3 232 ? 183.616 184.678 189.991 1.00 61.97 ? 232 PRO A CG  1 
ATOM   3484 C CD  . PRO C 3 232 ? 183.780 186.159 189.946 1.00 61.97 ? 232 PRO A CD  1 
ATOM   3485 N N   . GLU C 3 233 ? 187.523 186.091 189.619 1.00 63.01 ? 233 GLU A N   1 
ATOM   3486 C CA  . GLU C 3 233 ? 188.921 186.282 189.254 1.00 63.01 ? 233 GLU A CA  1 
ATOM   3487 C C   . GLU C 3 233 ? 189.723 186.807 190.435 1.00 63.01 ? 233 GLU A C   1 
ATOM   3488 O O   . GLU C 3 233 ? 190.836 186.335 190.700 1.00 63.01 ? 233 GLU A O   1 
ATOM   3489 C CB  . GLU C 3 233 ? 189.030 187.234 188.066 1.00 63.01 ? 233 GLU A CB  1 
ATOM   3490 C CG  . GLU C 3 233 ? 188.636 186.616 186.737 1.00 63.01 ? 233 GLU A CG  1 
ATOM   3491 C CD  . GLU C 3 233 ? 187.169 186.804 186.421 1.00 63.01 ? 233 GLU A CD  1 
ATOM   3492 O OE1 . GLU C 3 233 ? 186.666 187.933 186.591 1.00 63.01 ? 233 GLU A OE1 1 
ATOM   3493 O OE2 . GLU C 3 233 ? 186.519 185.825 186.000 1.00 63.01 ? 233 GLU A OE2 1 
ATOM   3494 N N   . MET C 3 234 ? 189.169 187.775 191.164 1.00 60.42 ? 234 MET A N   1 
ATOM   3495 C CA  . MET C 3 234 ? 189.848 188.288 192.346 1.00 60.42 ? 234 MET A CA  1 
ATOM   3496 C C   . MET C 3 234 ? 189.975 187.213 193.417 1.00 60.42 ? 234 MET A C   1 
ATOM   3497 O O   . MET C 3 234 ? 190.977 187.161 194.140 1.00 60.42 ? 234 MET A O   1 
ATOM   3498 C CB  . MET C 3 234 ? 189.105 189.505 192.886 1.00 60.42 ? 234 MET A CB  1 
ATOM   3499 C CG  . MET C 3 234 ? 189.433 190.784 192.154 1.00 60.42 ? 234 MET A CG  1 
ATOM   3500 S SD  . MET C 3 234 ? 191.198 191.117 192.153 1.00 60.42 ? 234 MET A SD  1 
ATOM   3501 C CE  . MET C 3 234 ? 191.340 192.154 193.605 1.00 60.42 ? 234 MET A CE  1 
ATOM   3502 N N   . LYS C 3 235 ? 188.970 186.344 193.534 1.00 59.58 ? 235 LYS A N   1 
ATOM   3503 C CA  . LYS C 3 235 ? 189.041 185.271 194.519 1.00 59.58 ? 235 LYS A CA  1 
ATOM   3504 C C   . LYS C 3 235 ? 190.172 184.301 194.200 1.00 59.58 ? 235 LYS A C   1 
ATOM   3505 O O   . LYS C 3 235 ? 190.926 183.902 195.094 1.00 59.58 ? 235 LYS A O   1 
ATOM   3506 C CB  . LYS C 3 235 ? 187.700 184.544 194.592 1.00 59.58 ? 235 LYS A CB  1 
ATOM   3507 C CG  . LYS C 3 235 ? 186.597 185.375 195.223 1.00 59.58 ? 235 LYS A CG  1 
ATOM   3508 C CD  . LYS C 3 235 ? 185.715 184.544 196.136 1.00 59.58 ? 235 LYS A CD  1 
ATOM   3509 C CE  . LYS C 3 235 ? 184.349 185.184 196.303 1.00 59.58 ? 235 LYS A CE  1 
ATOM   3510 N NZ  . LYS C 3 235 ? 183.260 184.170 196.321 1.00 59.58 ? 235 LYS A NZ  1 
ATOM   3511 N N   . ASP C 3 236 ? 190.318 183.922 192.929 1.00 58.40 ? 236 ASP A N   1 
ATOM   3512 C CA  . ASP C 3 236 ? 191.434 183.060 192.549 1.00 58.40 ? 236 ASP A CA  1 
ATOM   3513 C C   . ASP C 3 236 ? 192.770 183.769 192.743 1.00 58.40 ? 236 ASP A C   1 
ATOM   3514 O O   . ASP C 3 236 ? 193.754 183.154 193.186 1.00 58.40 ? 236 ASP A O   1 
ATOM   3515 C CB  . ASP C 3 236 ? 191.273 182.602 191.101 1.00 58.40 ? 236 ASP A CB  1 
ATOM   3516 C CG  . ASP C 3 236 ? 192.363 181.641 190.670 1.00 58.40 ? 236 ASP A CG  1 
ATOM   3517 O OD1 . ASP C 3 236 ? 192.611 180.656 191.398 1.00 58.40 ? 236 ASP A OD1 1 
ATOM   3518 O OD2 . ASP C 3 236 ? 192.972 181.870 189.604 1.00 58.40 ? 236 ASP A OD2 1 
ATOM   3519 N N   . PHE C 3 237 ? 192.818 185.064 192.420 1.00 53.18 ? 237 PHE A N   1 
ATOM   3520 C CA  . PHE C 3 237 ? 194.038 185.837 192.612 1.00 53.18 ? 237 PHE A CA  1 
ATOM   3521 C C   . PHE C 3 237 ? 194.467 185.836 194.073 1.00 53.18 ? 237 PHE A C   1 
ATOM   3522 O O   . PHE C 3 237 ? 195.654 185.675 194.379 1.00 53.18 ? 237 PHE A O   1 
ATOM   3523 C CB  . PHE C 3 237 ? 193.819 187.262 192.113 1.00 53.18 ? 237 PHE A CB  1 
ATOM   3524 C CG  . PHE C 3 237 ? 194.874 188.233 192.546 1.00 53.18 ? 237 PHE A CG  1 
ATOM   3525 C CD1 . PHE C 3 237 ? 194.734 188.953 193.715 1.00 53.18 ? 237 PHE A CD1 1 
ATOM   3526 C CD2 . PHE C 3 237 ? 195.988 188.457 191.764 1.00 53.18 ? 237 PHE A CD2 1 
ATOM   3527 C CE1 . PHE C 3 237 ? 195.695 189.852 194.108 1.00 53.18 ? 237 PHE A CE1 1 
ATOM   3528 C CE2 . PHE C 3 237 ? 196.948 189.360 192.154 1.00 53.18 ? 237 PHE A CE2 1 
ATOM   3529 C CZ  . PHE C 3 237 ? 196.800 190.057 193.327 1.00 53.18 ? 237 PHE A CZ  1 
ATOM   3530 N N   . ARG C 3 238 ? 193.515 186.019 194.989 1.00 53.54 ? 238 ARG A N   1 
ATOM   3531 C CA  . ARG C 3 238 ? 193.848 185.999 196.409 1.00 53.54 ? 238 ARG A CA  1 
ATOM   3532 C C   . ARG C 3 238 ? 194.174 184.592 196.893 1.00 53.54 ? 238 ARG A C   1 
ATOM   3533 O O   . ARG C 3 238 ? 195.001 184.424 197.799 1.00 53.54 ? 238 ARG A O   1 
ATOM   3534 C CB  . ARG C 3 238 ? 192.705 186.594 197.225 1.00 53.54 ? 238 ARG A CB  1 
ATOM   3535 C CG  . ARG C 3 238 ? 192.383 188.027 196.859 1.00 53.54 ? 238 ARG A CG  1 
ATOM   3536 C CD  . ARG C 3 238 ? 191.869 188.796 198.052 1.00 53.54 ? 238 ARG A CD  1 
ATOM   3537 N NE  . ARG C 3 238 ? 190.797 189.709 197.684 1.00 53.54 ? 238 ARG A NE  1 
ATOM   3538 C CZ  . ARG C 3 238 ? 189.512 189.388 197.684 1.00 53.54 ? 238 ARG A CZ  1 
ATOM   3539 N NH1 . ARG C 3 238 ? 189.103 188.178 198.021 1.00 53.54 ? 238 ARG A NH1 1 
ATOM   3540 N NH2 . ARG C 3 238 ? 188.614 190.306 197.337 1.00 53.54 ? 238 ARG A NH2 1 
ATOM   3541 N N   . HIS C 3 239 ? 193.536 183.574 196.314 1.00 51.79 ? 239 HIS A N   1 
ATOM   3542 C CA  . HIS C 3 239 ? 193.835 182.202 196.706 1.00 51.79 ? 239 HIS A CA  1 
ATOM   3543 C C   . HIS C 3 239 ? 195.277 181.841 196.379 1.00 51.79 ? 239 HIS A C   1 
ATOM   3544 O O   . HIS C 3 239 ? 195.944 181.135 197.152 1.00 51.79 ? 239 HIS A O   1 
ATOM   3545 C CB  . HIS C 3 239 ? 192.871 181.244 196.015 1.00 51.79 ? 239 HIS A CB  1 
ATOM   3546 C CG  . HIS C 3 239 ? 193.145 179.804 196.301 1.00 51.79 ? 239 HIS A CG  1 
ATOM   3547 N ND1 . HIS C 3 239 ? 193.077 179.273 197.570 1.00 51.79 ? 239 HIS A ND1 1 
ATOM   3548 C CD2 . HIS C 3 239 ? 193.487 178.782 195.483 1.00 51.79 ? 239 HIS A CD2 1 
ATOM   3549 C CE1 . HIS C 3 239 ? 193.366 177.985 197.522 1.00 51.79 ? 239 HIS A CE1 1 
ATOM   3550 N NE2 . HIS C 3 239 ? 193.618 177.662 196.267 1.00 51.79 ? 239 HIS A NE2 1 
ATOM   3551 N N   . GLY C 3 240 ? 195.771 182.307 195.232 1.00 50.40 ? 240 GLY A N   1 
ATOM   3552 C CA  . GLY C 3 240 ? 197.160 182.046 194.888 1.00 50.40 ? 240 GLY A CA  1 
ATOM   3553 C C   . GLY C 3 240 ? 198.123 182.564 195.940 1.00 50.40 ? 240 GLY A C   1 
ATOM   3554 O O   . GLY C 3 240 ? 199.059 181.869 196.350 1.00 50.40 ? 240 GLY A O   1 
ATOM   3555 N N   . PHE C 3 241 ? 197.893 183.788 196.412 1.00 49.63 ? 241 PHE A N   1 
ATOM   3556 C CA  . PHE C 3 241 ? 198.792 184.364 197.403 1.00 49.63 ? 241 PHE A CA  1 
ATOM   3557 C C   . PHE C 3 241 ? 198.589 183.740 198.775 1.00 49.63 ? 241 PHE A C   1 
ATOM   3558 O O   . PHE C 3 241 ? 199.533 183.681 199.568 1.00 49.63 ? 241 PHE A O   1 
ATOM   3559 C CB  . PHE C 3 241 ? 198.609 185.875 197.459 1.00 49.63 ? 241 PHE A CB  1 
ATOM   3560 C CG  . PHE C 3 241 ? 199.270 186.597 196.327 1.00 49.63 ? 241 PHE A CG  1 
ATOM   3561 C CD1 . PHE C 3 241 ? 200.629 186.830 196.343 1.00 49.63 ? 241 PHE A CD1 1 
ATOM   3562 C CD2 . PHE C 3 241 ? 198.536 187.027 195.243 1.00 49.63 ? 241 PHE A CD2 1 
ATOM   3563 C CE1 . PHE C 3 241 ? 201.241 187.490 195.304 1.00 49.63 ? 241 PHE A CE1 1 
ATOM   3564 C CE2 . PHE C 3 241 ? 199.146 187.687 194.199 1.00 49.63 ? 241 PHE A CE2 1 
ATOM   3565 C CZ  . PHE C 3 241 ? 200.500 187.918 194.232 1.00 49.63 ? 241 PHE A CZ  1 
ATOM   3566 N N   . ASP C 3 242 ? 197.380 183.257 199.070 1.00 47.76 ? 242 ASP A N   1 
ATOM   3567 C CA  . ASP C 3 242 ? 197.184 182.462 200.280 1.00 47.76 ? 242 ASP A CA  1 
ATOM   3568 C C   . ASP C 3 242 ? 198.076 181.227 200.264 1.00 47.76 ? 242 ASP A C   1 
ATOM   3569 O O   . ASP C 3 242 ? 198.769 180.925 201.246 1.00 47.76 ? 242 ASP A O   1 
ATOM   3570 C CB  . ASP C 3 242 ? 195.717 182.053 200.408 1.00 47.76 ? 242 ASP A CB  1 
ATOM   3571 C CG  . ASP C 3 242 ? 194.952 182.909 201.392 1.00 47.76 ? 242 ASP A CG  1 
ATOM   3572 O OD1 . ASP C 3 242 ? 195.430 184.013 201.724 1.00 47.76 ? 242 ASP A OD1 1 
ATOM   3573 O OD2 . ASP C 3 242 ? 193.866 182.477 201.830 1.00 47.76 ? 242 ASP A OD2 1 
ATOM   3574 N N   . ILE C 3 243 ? 198.088 180.513 199.136 1.00 47.85 ? 243 ILE A N   1 
ATOM   3575 C CA  . ILE C 3 243 ? 198.938 179.331 199.011 1.00 47.85 ? 243 ILE A CA  1 
ATOM   3576 C C   . ILE C 3 243 ? 200.408 179.712 199.128 1.00 47.85 ? 243 ILE A C   1 
ATOM   3577 O O   . ILE C 3 243 ? 201.203 179.005 199.764 1.00 47.85 ? 243 ILE A O   1 
ATOM   3578 C CB  . ILE C 3 243 ? 198.647 178.603 197.686 1.00 47.85 ? 243 ILE A CB  1 
ATOM   3579 C CG1 . ILE C 3 243 ? 197.222 178.055 197.683 1.00 47.85 ? 243 ILE A CG1 1 
ATOM   3580 C CG2 . ILE C 3 243 ? 199.640 177.485 197.462 1.00 47.85 ? 243 ILE A CG2 1 
ATOM   3581 C CD1 . ILE C 3 243 ? 197.020 176.874 198.601 1.00 47.85 ? 243 ILE A CD1 1 
ATOM   3582 N N   . LEU C 3 244 ? 200.795 180.830 198.512 1.00 47.29 ? 244 LEU A N   1 
ATOM   3583 C CA  . LEU C 3 244 ? 202.189 181.259 198.575 1.00 47.29 ? 244 LEU A CA  1 
ATOM   3584 C C   . LEU C 3 244 ? 202.615 181.569 200.005 1.00 47.29 ? 244 LEU A C   1 
ATOM   3585 O O   . LEU C 3 244 ? 203.712 181.183 200.433 1.00 47.29 ? 244 LEU A O   1 
ATOM   3586 C CB  . LEU C 3 244 ? 202.403 182.477 197.681 1.00 47.29 ? 244 LEU A CB  1 
ATOM   3587 C CG  . LEU C 3 244 ? 203.696 183.256 197.896 1.00 47.29 ? 244 LEU A CG  1 
ATOM   3588 C CD1 . LEU C 3 244 ? 204.835 182.625 197.126 1.00 47.29 ? 244 LEU A CD1 1 
ATOM   3589 C CD2 . LEU C 3 244 ? 203.511 184.702 197.488 1.00 47.29 ? 244 LEU A CD2 1 
ATOM   3590 N N   . VAL C 3 245 ? 201.765 182.269 200.758 1.00 45.08 ? 245 VAL A N   1 
ATOM   3591 C CA  . VAL C 3 245 ? 202.090 182.581 202.145 1.00 45.08 ? 245 VAL A CA  1 
ATOM   3592 C C   . VAL C 3 245 ? 202.162 181.305 202.973 1.00 45.08 ? 245 VAL A C   1 
ATOM   3593 O O   . VAL C 3 245 ? 202.997 181.183 203.873 1.00 45.08 ? 245 VAL A O   1 
ATOM   3594 C CB  . VAL C 3 245 ? 201.081 183.588 202.722 1.00 45.08 ? 245 VAL A CB  1 
ATOM   3595 C CG1 . VAL C 3 245 ? 201.319 183.792 204.194 1.00 45.08 ? 245 VAL A CG1 1 
ATOM   3596 C CG2 . VAL C 3 245 ? 201.190 184.912 201.995 1.00 45.08 ? 245 VAL A CG2 1 
ATOM   3597 N N   . GLY C 3 246 ? 201.311 180.323 202.668 1.00 47.33 ? 246 GLY A N   1 
ATOM   3598 C CA  . GLY C 3 246 ? 201.416 179.041 203.350 1.00 47.33 ? 246 GLY A CA  1 
ATOM   3599 C C   . GLY C 3 246 ? 202.742 178.344 203.100 1.00 47.33 ? 246 GLY A C   1 
ATOM   3600 O O   . GLY C 3 246 ? 203.351 177.790 204.022 1.00 47.33 ? 246 GLY A O   1 
ATOM   3601 N N   . GLN C 3 247 ? 203.204 178.354 201.849 1.00 49.41 ? 247 GLN A N   1 
ATOM   3602 C CA  . GLN C 3 247 ? 204.492 177.735 201.540 1.00 49.41 ? 247 GLN A CA  1 
ATOM   3603 C C   . GLN C 3 247 ? 205.644 178.469 202.223 1.00 49.41 ? 247 GLN A C   1 
ATOM   3604 O O   . GLN C 3 247 ? 206.572 177.835 202.747 1.00 49.41 ? 247 GLN A O   1 
ATOM   3605 C CB  . GLN C 3 247 ? 204.699 177.684 200.030 1.00 49.41 ? 247 GLN A CB  1 
ATOM   3606 C CG  . GLN C 3 247 ? 203.602 176.947 199.289 1.00 49.41 ? 247 GLN A CG  1 
ATOM   3607 C CD  . GLN C 3 247 ? 203.815 176.945 197.795 1.00 49.41 ? 247 GLN A CD  1 
ATOM   3608 O OE1 . GLN C 3 247 ? 202.861 176.941 197.020 1.00 49.41 ? 247 GLN A OE1 1 
ATOM   3609 N NE2 . GLN C 3 247 ? 205.075 176.947 197.378 1.00 49.41 ? 247 GLN A NE2 1 
ATOM   3610 N N   . ILE C 3 248 ? 205.598 179.804 202.231 1.00 47.74 ? 248 ILE A N   1 
ATOM   3611 C CA  . ILE C 3 248 ? 206.610 180.573 202.952 1.00 47.74 ? 248 ILE A CA  1 
ATOM   3612 C C   . ILE C 3 248 ? 206.579 180.226 204.433 1.00 47.74 ? 248 ILE A C   1 
ATOM   3613 O O   . ILE C 3 248 ? 207.623 180.139 205.087 1.00 47.74 ? 248 ILE A O   1 
ATOM   3614 C CB  . ILE C 3 248 ? 206.407 182.083 202.729 1.00 47.74 ? 248 ILE A CB  1 
ATOM   3615 C CG1 . ILE C 3 248 ? 206.532 182.437 201.251 1.00 47.74 ? 248 ILE A CG1 1 
ATOM   3616 C CG2 . ILE C 3 248 ? 207.422 182.871 203.513 1.00 47.74 ? 248 ILE A CG2 1 
ATOM   3617 C CD1 . ILE C 3 248 ? 206.082 183.844 200.937 1.00 47.74 ? 248 ILE A CD1 1 
ATOM   3618 N N   . ASP C 3 249 ? 205.380 180.034 204.987 1.00 50.68 ? 249 ASP A N   1 
ATOM   3619 C CA  . ASP C 3 249 ? 205.248 179.671 206.393 1.00 50.68 ? 249 ASP A CA  1 
ATOM   3620 C C   . ASP C 3 249 ? 205.887 178.319 206.678 1.00 50.68 ? 249 ASP A C   1 
ATOM   3621 O O   . ASP C 3 249 ? 206.562 178.147 207.697 1.00 50.68 ? 249 ASP A O   1 
ATOM   3622 C CB  . ASP C 3 249 ? 203.772 179.654 206.786 1.00 50.68 ? 249 ASP A CB  1 
ATOM   3623 C CG  . ASP C 3 249 ? 203.563 179.379 208.255 1.00 50.68 ? 249 ASP A CG  1 
ATOM   3624 O OD1 . ASP C 3 249 ? 204.568 179.219 208.981 1.00 50.68 ? 249 ASP A OD1 1 
ATOM   3625 O OD2 . ASP C 3 249 ? 202.395 179.312 208.686 1.00 50.68 ? 249 ASP A OD2 1 
ATOM   3626 N N   . ASP C 3 250 ? 205.667 177.342 205.797 1.00 50.59 ? 250 ASP A N   1 
ATOM   3627 C CA  . ASP C 3 250 ? 206.293 176.035 205.978 1.00 50.59 ? 250 ASP A CA  1 
ATOM   3628 C C   . ASP C 3 250 ? 207.812 176.144 205.938 1.00 50.59 ? 250 ASP A C   1 
ATOM   3629 O O   . ASP C 3 250 ? 208.515 175.538 206.761 1.00 50.59 ? 250 ASP A O   1 
ATOM   3630 C CB  . ASP C 3 250 ? 205.803 175.063 204.905 1.00 50.59 ? 250 ASP A CB  1 
ATOM   3631 C CG  . ASP C 3 250 ? 204.606 174.254 205.353 1.00 50.59 ? 250 ASP A CG  1 
ATOM   3632 O OD1 . ASP C 3 250 ? 204.659 173.676 206.459 1.00 50.59 ? 250 ASP A OD1 1 
ATOM   3633 O OD2 . ASP C 3 250 ? 203.614 174.190 204.598 1.00 50.59 ? 250 ASP A OD2 1 
ATOM   3634 N N   . ALA C 3 251 ? 208.338 176.912 204.980 1.00 50.41 ? 251 ALA A N   1 
ATOM   3635 C CA  . ALA C 3 251 ? 209.785 177.086 204.895 1.00 50.41 ? 251 ALA A CA  1 
ATOM   3636 C C   . ALA C 3 251 ? 210.331 177.767 206.142 1.00 50.41 ? 251 ALA A C   1 
ATOM   3637 O O   . ALA C 3 251 ? 211.384 177.380 206.663 1.00 50.41 ? 251 ALA A O   1 
ATOM   3638 C CB  . ALA C 3 251 ? 210.146 177.886 203.646 1.00 50.41 ? 251 ALA A CB  1 
ATOM   3639 N N   . LEU C 3 252 ? 209.628 178.787 206.634 1.00 49.45 ? 252 LEU A N   1 
ATOM   3640 C CA  . LEU C 3 252 ? 210.057 179.487 207.839 1.00 49.45 ? 252 LEU A CA  1 
ATOM   3641 C C   . LEU C 3 252 ? 210.035 178.565 209.045 1.00 49.45 ? 252 LEU A C   1 
ATOM   3642 O O   . LEU C 3 252 ? 210.914 178.638 209.908 1.00 49.45 ? 252 LEU A O   1 
ATOM   3643 C CB  . LEU C 3 252 ? 209.160 180.699 208.078 1.00 49.45 ? 252 LEU A CB  1 
ATOM   3644 C CG  . LEU C 3 252 ? 209.680 181.802 208.994 1.00 49.45 ? 252 LEU A CG  1 
ATOM   3645 C CD1 . LEU C 3 252 ? 211.162 182.020 208.781 1.00 49.45 ? 252 LEU A CD1 1 
ATOM   3646 C CD2 . LEU C 3 252 ? 208.910 183.083 208.746 1.00 49.45 ? 252 LEU A CD2 1 
ATOM   3647 N N   . LYS C 3 253 ? 209.021 177.706 209.135 1.00 50.17 ? 253 LYS A N   1 
ATOM   3648 C CA  . LYS C 3 253 ? 208.951 176.741 210.226 1.00 50.17 ? 253 LYS A CA  1 
ATOM   3649 C C   . LYS C 3 253 ? 210.144 175.798 210.199 1.00 50.17 ? 253 LYS A C   1 
ATOM   3650 O O   . LYS C 3 253 ? 210.797 175.567 211.226 1.00 50.17 ? 253 LYS A O   1 
ATOM   3651 C CB  . LYS C 3 253 ? 207.644 175.960 210.128 1.00 50.17 ? 253 LYS A CB  1 
ATOM   3652 C CG  . LYS C 3 253 ? 207.516 174.807 211.096 1.00 50.17 ? 253 LYS A CG  1 
ATOM   3653 C CD  . LYS C 3 253 ? 206.069 174.375 211.213 1.00 50.17 ? 253 LYS A CD  1 
ATOM   3654 C CE  . LYS C 3 253 ? 205.147 175.570 211.349 1.00 50.17 ? 253 LYS A CE  1 
ATOM   3655 N NZ  . LYS C 3 253 ? 203.715 175.171 211.295 1.00 50.17 ? 253 LYS A NZ  1 
ATOM   3656 N N   . LEU C 3 254 ? 210.454 175.254 209.021 1.00 53.69 ? 254 LEU A N   1 
ATOM   3657 C CA  . LEU C 3 254 ? 211.602 174.359 208.914 1.00 53.69 ? 254 LEU A CA  1 
ATOM   3658 C C   . LEU C 3 254 ? 212.897 175.083 209.264 1.00 53.69 ? 254 LEU A C   1 
ATOM   3659 O O   . LEU C 3 254 ? 213.764 174.522 209.943 1.00 53.69 ? 254 LEU A O   1 
ATOM   3660 C CB  . LEU C 3 254 ? 211.681 173.765 207.511 1.00 53.69 ? 254 LEU A CB  1 
ATOM   3661 C CG  . LEU C 3 254 ? 211.125 172.352 207.345 1.00 53.69 ? 254 LEU A CG  1 
ATOM   3662 C CD1 . LEU C 3 254 ? 211.875 171.380 208.237 1.00 53.69 ? 254 LEU A CD1 1 
ATOM   3663 C CD2 . LEU C 3 254 ? 209.637 172.319 207.641 1.00 53.69 ? 254 LEU A CD2 1 
ATOM   3664 N N   . ALA C 3 255 ? 213.046 176.330 208.810 1.00 53.70 ? 255 ALA A N   1 
ATOM   3665 C CA  . ALA C 3 255 ? 214.255 177.089 209.115 1.00 53.70 ? 255 ALA A CA  1 
ATOM   3666 C C   . ALA C 3 255 ? 214.382 177.366 210.607 1.00 53.70 ? 255 ALA A C   1 
ATOM   3667 O O   . ALA C 3 255 ? 215.467 177.223 211.181 1.00 53.70 ? 255 ALA A O   1 
ATOM   3668 C CB  . ALA C 3 255 ? 214.264 178.398 208.330 1.00 53.70 ? 255 ALA A CB  1 
ATOM   3669 N N   . ASN C 3 256 ? 213.286 177.769 211.254 1.00 54.54 ? 256 ASN A N   1 
ATOM   3670 C CA  . ASN C 3 256 ? 213.327 178.040 212.687 1.00 54.54 ? 256 ASN A CA  1 
ATOM   3671 C C   . ASN C 3 256 ? 213.620 176.780 213.483 1.00 54.54 ? 256 ASN A C   1 
ATOM   3672 O O   . ASN C 3 256 ? 214.229 176.855 214.556 1.00 54.54 ? 256 ASN A O   1 
ATOM   3673 C CB  . ASN C 3 256 ? 212.008 178.656 213.150 1.00 54.54 ? 256 ASN A CB  1 
ATOM   3674 C CG  . ASN C 3 256 ? 211.959 180.154 212.946 1.00 54.54 ? 256 ASN A CG  1 
ATOM   3675 O OD1 . ASN C 3 256 ? 212.877 180.873 213.334 1.00 54.54 ? 256 ASN A OD1 1 
ATOM   3676 N ND2 . ASN C 3 256 ? 210.881 180.633 212.340 1.00 54.54 ? 256 ASN A ND2 1 
ATOM   3677 N N   . GLU C 3 257 ? 213.188 175.618 212.985 1.00 58.84 ? 257 GLU A N   1 
ATOM   3678 C CA  . GLU C 3 257 ? 213.520 174.371 213.667 1.00 58.84 ? 257 GLU A CA  1 
ATOM   3679 C C   . GLU C 3 257 ? 215.027 174.167 213.729 1.00 58.84 ? 257 GLU A C   1 
ATOM   3680 O O   . GLU C 3 257 ? 215.561 173.734 214.756 1.00 58.84 ? 257 GLU A O   1 
ATOM   3681 C CB  . GLU C 3 257 ? 212.847 173.191 212.968 1.00 58.84 ? 257 GLU A CB  1 
ATOM   3682 C CG  . GLU C 3 257 ? 212.312 172.135 213.919 1.00 58.84 ? 257 GLU A CG  1 
ATOM   3683 C CD  . GLU C 3 257 ? 211.061 171.459 213.395 1.00 58.84 ? 257 GLU A CD  1 
ATOM   3684 O OE1 . GLU C 3 257 ? 209.965 172.042 213.534 1.00 58.84 ? 257 GLU A OE1 1 
ATOM   3685 O OE2 . GLU C 3 257 ? 211.174 170.344 212.843 1.00 58.84 ? 257 GLU A OE2 1 
ATOM   3686 N N   . GLY C 3 258 ? 215.729 174.475 212.644 1.00 58.24 ? 258 GLY A N   1 
ATOM   3687 C CA  . GLY C 3 258 ? 217.173 174.373 212.622 1.00 58.24 ? 258 GLY A CA  1 
ATOM   3688 C C   . GLY C 3 258 ? 217.732 173.881 211.303 1.00 58.24 ? 258 GLY A C   1 
ATOM   3689 O O   . GLY C 3 258 ? 218.898 174.134 210.986 1.00 58.24 ? 258 GLY A O   1 
ATOM   3690 N N   . LYS C 3 259 ? 216.909 173.191 210.517 1.00 59.14 ? 259 LYS A N   1 
ATOM   3691 C CA  . LYS C 3 259 ? 217.352 172.598 209.256 1.00 59.14 ? 259 LYS A CA  1 
ATOM   3692 C C   . LYS C 3 259 ? 217.462 173.698 208.209 1.00 59.14 ? 259 LYS A C   1 
ATOM   3693 O O   . LYS C 3 259 ? 216.461 174.291 207.803 1.00 59.14 ? 259 LYS A O   1 
ATOM   3694 C CB  . LYS C 3 259 ? 216.393 171.504 208.801 1.00 59.14 ? 259 LYS A CB  1 
ATOM   3695 C CG  . LYS C 3 259 ? 215.951 170.520 209.880 1.00 59.14 ? 259 LYS A CG  1 
ATOM   3696 C CD  . LYS C 3 259 ? 217.099 170.074 210.775 1.00 59.14 ? 259 LYS A CD  1 
ATOM   3697 C CE  . LYS C 3 259 ? 216.608 169.132 211.863 1.00 59.14 ? 259 LYS A CE  1 
ATOM   3698 N NZ  . LYS C 3 259 ? 215.532 169.750 212.687 1.00 59.14 ? 259 LYS A NZ  1 
ATOM   3699 N N   . VAL C 3 260 ? 218.688 173.972 207.767 1.00 59.10 ? 260 VAL A N   1 
ATOM   3700 C CA  . VAL C 3 260 ? 218.904 174.993 206.748 1.00 59.10 ? 260 VAL A CA  1 
ATOM   3701 C C   . VAL C 3 260 ? 218.660 174.419 205.358 1.00 59.10 ? 260 VAL A C   1 
ATOM   3702 O O   . VAL C 3 260 ? 217.927 174.998 204.546 1.00 59.10 ? 260 VAL A O   1 
ATOM   3703 C CB  . VAL C 3 260 ? 220.320 175.575 206.878 1.00 59.10 ? 260 VAL A CB  1 
ATOM   3704 C CG1 . VAL C 3 260 ? 220.703 176.330 205.618 1.00 59.10 ? 260 VAL A CG1 1 
ATOM   3705 C CG2 . VAL C 3 260 ? 220.410 176.472 208.099 1.00 59.10 ? 260 VAL A CG2 1 
ATOM   3706 N N   . LYS C 3 261 ? 219.273 173.271 205.064 1.00 61.20 ? 261 LYS A N   1 
ATOM   3707 C CA  . LYS C 3 261 ? 219.120 172.664 203.747 1.00 61.20 ? 261 LYS A CA  1 
ATOM   3708 C C   . LYS C 3 261 ? 217.672 172.268 203.485 1.00 61.20 ? 261 LYS A C   1 
ATOM   3709 O O   . LYS C 3 261 ? 217.163 172.443 202.372 1.00 61.20 ? 261 LYS A O   1 
ATOM   3710 C CB  . LYS C 3 261 ? 220.038 171.451 203.621 1.00 61.20 ? 261 LYS A CB  1 
ATOM   3711 C CG  . LYS C 3 261 ? 221.456 171.793 203.209 1.00 61.20 ? 261 LYS A CG  1 
ATOM   3712 C CD  . LYS C 3 261 ? 222.339 170.557 203.206 1.00 61.20 ? 261 LYS A CD  1 
ATOM   3713 C CE  . LYS C 3 261 ? 223.814 170.925 203.196 1.00 61.20 ? 261 LYS A CE  1 
ATOM   3714 N NZ  . LYS C 3 261 ? 224.030 172.398 203.203 1.00 61.20 ? 261 LYS A NZ  1 
ATOM   3715 N N   . GLU C 3 262 ? 216.995 171.723 204.496 1.00 59.99 ? 262 GLU A N   1 
ATOM   3716 C CA  . GLU C 3 262 ? 215.585 171.399 204.329 1.00 59.99 ? 262 GLU A CA  1 
ATOM   3717 C C   . GLU C 3 262 ? 214.746 172.653 204.143 1.00 59.99 ? 262 GLU A C   1 
ATOM   3718 O O   . GLU C 3 262 ? 213.761 172.634 203.396 1.00 59.99 ? 262 GLU A O   1 
ATOM   3719 C CB  . GLU C 3 262 ? 215.088 170.590 205.521 1.00 59.99 ? 262 GLU A CB  1 
ATOM   3720 C CG  . GLU C 3 262 ? 215.684 169.204 205.574 1.00 59.99 ? 262 GLU A CG  1 
ATOM   3721 C CD  . GLU C 3 262 ? 215.467 168.449 204.282 1.00 59.99 ? 262 GLU A CD  1 
ATOM   3722 O OE1 . GLU C 3 262 ? 216.467 168.064 203.641 1.00 59.99 ? 262 GLU A OE1 1 
ATOM   3723 O OE2 . GLU C 3 262 ? 214.294 168.251 203.902 1.00 59.99 ? 262 GLU A OE2 1 
ATOM   3724 N N   . ALA C 3 263 ? 215.119 173.749 204.804 1.00 57.77 ? 263 ALA A N   1 
ATOM   3725 C CA  . ALA C 3 263 ? 214.429 175.014 204.584 1.00 57.77 ? 263 ALA A CA  1 
ATOM   3726 C C   . ALA C 3 263 ? 214.567 175.465 203.139 1.00 57.77 ? 263 ALA A C   1 
ATOM   3727 O O   . ALA C 3 263 ? 213.600 175.932 202.530 1.00 57.77 ? 263 ALA A O   1 
ATOM   3728 C CB  . ALA C 3 263 ? 214.975 176.080 205.531 1.00 57.77 ? 263 ALA A CB  1 
ATOM   3729 N N   . GLN C 3 264 ? 215.764 175.329 202.571 1.00 57.89 ? 264 GLN A N   1 
ATOM   3730 C CA  . GLN C 3 264 ? 215.955 175.655 201.163 1.00 57.89 ? 264 GLN A CA  1 
ATOM   3731 C C   . GLN C 3 264 ? 215.135 174.740 200.258 1.00 57.89 ? 264 GLN A C   1 
ATOM   3732 O O   . GLN C 3 264 ? 214.528 175.197 199.279 1.00 57.89 ? 264 GLN A O   1 
ATOM   3733 C CB  . GLN C 3 264 ? 217.436 175.568 200.814 1.00 57.89 ? 264 GLN A CB  1 
ATOM   3734 C CG  . GLN C 3 264 ? 218.323 176.426 201.696 1.00 57.89 ? 264 GLN A CG  1 
ATOM   3735 C CD  . GLN C 3 264 ? 219.555 176.906 200.966 1.00 57.89 ? 264 GLN A CD  1 
ATOM   3736 O OE1 . GLN C 3 264 ? 219.584 176.934 199.739 1.00 57.89 ? 264 GLN A OE1 1 
ATOM   3737 N NE2 . GLN C 3 264 ? 220.582 177.285 201.715 1.00 57.89 ? 264 GLN A NE2 1 
ATOM   3738 N N   . ALA C 3 265 ? 215.119 173.440 200.560 1.00 57.57 ? 265 ALA A N   1 
ATOM   3739 C CA  . ALA C 3 265 ? 214.347 172.501 199.751 1.00 57.57 ? 265 ALA A CA  1 
ATOM   3740 C C   . ALA C 3 265 ? 212.865 172.850 199.773 1.00 57.57 ? 265 ALA A C   1 
ATOM   3741 O O   . ALA C 3 265 ? 212.186 172.778 198.742 1.00 57.57 ? 265 ALA A O   1 
ATOM   3742 C CB  . ALA C 3 265 ? 214.573 171.072 200.241 1.00 57.57 ? 265 ALA A CB  1 
ATOM   3743 N N   . ALA C 3 266 ? 212.349 173.239 200.939 1.00 57.10 ? 266 ALA A N   1 
ATOM   3744 C CA  . ALA C 3 266 ? 210.971 173.704 201.042 1.00 57.10 ? 266 ALA A CA  1 
ATOM   3745 C C   . ALA C 3 266 ? 210.759 175.049 200.360 1.00 57.10 ? 266 ALA A C   1 
ATOM   3746 O O   . ALA C 3 266 ? 209.649 175.328 199.899 1.00 57.10 ? 266 ALA A O   1 
ATOM   3747 C CB  . ALA C 3 266 ? 210.557 173.791 202.512 1.00 57.10 ? 266 ALA A CB  1 
ATOM   3748 N N   . ALA C 3 267 ? 211.789 175.893 200.298 1.00 56.48 ? 267 ALA A N   1 
ATOM   3749 C CA  . ALA C 3 267 ? 211.646 177.189 199.644 1.00 56.48 ? 267 ALA A CA  1 
ATOM   3750 C C   . ALA C 3 267 ? 211.625 177.059 198.129 1.00 56.48 ? 267 ALA A C   1 
ATOM   3751 O O   . ALA C 3 267 ? 211.044 177.905 197.443 1.00 56.48 ? 267 ALA A O   1 
ATOM   3752 C CB  . ALA C 3 267 ? 212.777 178.121 200.073 1.00 56.48 ? 267 ALA A CB  1 
ATOM   3753 N N   . GLU C 3 268 ? 212.259 176.021 197.587 1.00 59.01 ? 268 GLU A N   1 
ATOM   3754 C CA  . GLU C 3 268 ? 212.221 175.843 196.138 1.00 59.01 ? 268 GLU A CA  1 
ATOM   3755 C C   . GLU C 3 268 ? 210.804 175.668 195.600 1.00 59.01 ? 268 GLU A C   1 
ATOM   3756 O O   . GLU C 3 268 ? 210.581 175.890 194.405 1.00 59.01 ? 268 GLU A O   1 
ATOM   3757 C CB  . GLU C 3 268 ? 213.086 174.663 195.692 1.00 59.01 ? 268 GLU A CB  1 
ATOM   3758 C CG  . GLU C 3 268 ? 214.594 174.867 195.816 1.00 59.01 ? 268 GLU A CG  1 
ATOM   3759 C CD  . GLU C 3 268 ? 215.267 173.838 196.693 1.00 59.01 ? 268 GLU A CD  1 
ATOM   3760 O OE1 . GLU C 3 268 ? 214.912 172.650 196.569 1.00 59.01 ? 268 GLU A OE1 1 
ATOM   3761 O OE2 . GLU C 3 268 ? 216.196 174.196 197.449 1.00 59.01 ? 268 GLU A OE2 1 
ATOM   3762 N N   . GLN C 3 269 ? 209.844 175.285 196.446 1.00 56.82 ? 269 GLN A N   1 
ATOM   3763 C CA  . GLN C 3 269 ? 208.480 175.055 195.978 1.00 56.82 ? 269 GLN A CA  1 
ATOM   3764 C C   . GLN C 3 269 ? 207.793 176.345 195.537 1.00 56.82 ? 269 GLN A C   1 
ATOM   3765 O O   . GLN C 3 269 ? 206.742 176.290 194.889 1.00 56.82 ? 269 GLN A O   1 
ATOM   3766 C CB  . GLN C 3 269 ? 207.661 174.372 197.072 1.00 56.82 ? 269 GLN A CB  1 
ATOM   3767 C CG  . GLN C 3 269 ? 208.356 173.191 197.731 1.00 56.82 ? 269 GLN A CG  1 
ATOM   3768 C CD  . GLN C 3 269 ? 208.891 172.194 196.727 1.00 56.82 ? 269 GLN A CD  1 
ATOM   3769 O OE1 . GLN C 3 269 ? 208.127 171.557 196.004 1.00 56.82 ? 269 GLN A OE1 1 
ATOM   3770 N NE2 . GLN C 3 269 ? 210.210 172.062 196.668 1.00 56.82 ? 269 GLN A NE2 1 
ATOM   3771 N N   . LEU C 3 270 ? 208.355 177.506 195.881 1.00 53.88 ? 270 LEU A N   1 
ATOM   3772 C CA  . LEU C 3 270 ? 207.761 178.777 195.477 1.00 53.88 ? 270 LEU A CA  1 
ATOM   3773 C C   . LEU C 3 270 ? 207.858 179.018 193.976 1.00 53.88 ? 270 LEU A C   1 
ATOM   3774 O O   . LEU C 3 270 ? 207.109 179.843 193.434 1.00 53.88 ? 270 LEU A O   1 
ATOM   3775 C CB  . LEU C 3 270 ? 208.435 179.922 196.229 1.00 53.88 ? 270 LEU A CB  1 
ATOM   3776 C CG  . LEU C 3 270 ? 208.437 179.770 197.747 1.00 53.88 ? 270 LEU A CG  1 
ATOM   3777 C CD1 . LEU C 3 270 ? 209.370 180.772 198.379 1.00 53.88 ? 270 LEU A CD1 1 
ATOM   3778 C CD2 . LEU C 3 270 ? 207.035 179.939 198.293 1.00 53.88 ? 270 LEU A CD2 1 
ATOM   3779 N N   . LYS C 3 271 ? 208.770 178.329 193.293 1.00 53.92 ? 271 LYS A N   1 
ATOM   3780 C CA  . LYS C 3 271 ? 208.898 178.525 191.857 1.00 53.92 ? 271 LYS A CA  1 
ATOM   3781 C C   . LYS C 3 271 ? 207.647 178.070 191.120 1.00 53.92 ? 271 LYS A C   1 
ATOM   3782 O O   . LYS C 3 271 ? 207.286 178.661 190.097 1.00 53.92 ? 271 LYS A O   1 
ATOM   3783 C CB  . LYS C 3 271 ? 210.130 177.789 191.335 1.00 53.92 ? 271 LYS A CB  1 
ATOM   3784 C CG  . LYS C 3 271 ? 211.440 178.345 191.857 1.00 53.92 ? 271 LYS A CG  1 
ATOM   3785 C CD  . LYS C 3 271 ? 212.544 178.201 190.826 1.00 53.92 ? 271 LYS A CD  1 
ATOM   3786 C CE  . LYS C 3 271 ? 212.924 176.746 190.623 1.00 53.92 ? 271 LYS A CE  1 
ATOM   3787 N NZ  . LYS C 3 271 ? 213.113 176.044 191.921 1.00 53.92 ? 271 LYS A NZ  1 
ATOM   3788 N N   . THR C 3 272 ? 206.966 177.039 191.625 1.00 52.34 ? 272 THR A N   1 
ATOM   3789 C CA  . THR C 3 272 ? 205.753 176.569 190.966 1.00 52.34 ? 272 THR A CA  1 
ATOM   3790 C C   . THR C 3 272 ? 204.656 177.627 191.003 1.00 52.34 ? 272 THR A C   1 
ATOM   3791 O O   . THR C 3 272 ? 203.990 177.876 189.991 1.00 52.34 ? 272 THR A O   1 
ATOM   3792 C CB  . THR C 3 272 ? 205.271 175.273 191.611 1.00 52.34 ? 272 THR A CB  1 
ATOM   3793 O OG1 . THR C 3 272 ? 206.359 174.346 191.694 1.00 52.34 ? 272 THR A OG1 1 
ATOM   3794 C CG2 . THR C 3 272 ? 204.158 174.657 190.784 1.00 52.34 ? 272 THR A CG2 1 
ATOM   3795 N N   . THR C 3 273 ? 204.462 178.276 192.153 1.00 51.33 ? 273 THR A N   1 
ATOM   3796 C CA  . THR C 3 273 ? 203.433 179.307 192.219 1.00 51.33 ? 273 THR A CA  1 
ATOM   3797 C C   . THR C 3 273 ? 203.859 180.566 191.475 1.00 51.33 ? 273 THR A C   1 
ATOM   3798 O O   . THR C 3 273 ? 203.007 181.276 190.927 1.00 51.33 ? 273 THR A O   1 
ATOM   3799 C CB  . THR C 3 273 ? 203.071 179.623 193.672 1.00 51.33 ? 273 THR A CB  1 
ATOM   3800 O OG1 . THR C 3 273 ? 201.996 180.568 193.701 1.00 51.33 ? 273 THR A OG1 1 
ATOM   3801 C CG2 . THR C 3 273 ? 204.247 180.192 194.423 1.00 51.33 ? 273 THR A CG2 1 
ATOM   3802 N N   . ARG C 3 274 ? 205.165 180.843 191.407 1.00 51.92 ? 274 ARG A N   1 
ATOM   3803 C CA  . ARG C 3 274 ? 205.625 181.939 190.560 1.00 51.92 ? 274 ARG A CA  1 
ATOM   3804 C C   . ARG C 3 274 ? 205.292 181.662 189.096 1.00 51.92 ? 274 ARG A C   1 
ATOM   3805 O O   . ARG C 3 274 ? 204.820 182.552 188.377 1.00 51.92 ? 274 ARG A O   1 
ATOM   3806 C CB  . ARG C 3 274 ? 207.128 182.148 190.758 1.00 51.92 ? 274 ARG A CB  1 
ATOM   3807 C CG  . ARG C 3 274 ? 207.837 182.987 189.701 1.00 51.92 ? 274 ARG A CG  1 
ATOM   3808 C CD  . ARG C 3 274 ? 207.145 184.321 189.454 1.00 51.92 ? 274 ARG A CD  1 
ATOM   3809 N NE  . ARG C 3 274 ? 207.945 185.203 188.612 1.00 51.92 ? 274 ARG A NE  1 
ATOM   3810 C CZ  . ARG C 3 274 ? 207.930 186.526 188.686 1.00 51.92 ? 274 ARG A CZ  1 
ATOM   3811 N NH1 . ARG C 3 274 ? 207.162 187.161 189.554 1.00 51.92 ? 274 ARG A NH1 1 
ATOM   3812 N NH2 . ARG C 3 274 ? 208.707 187.229 187.868 1.00 51.92 ? 274 ARG A NH2 1 
ATOM   3813 N N   . ASN C 3 275 ? 205.511 180.424 188.643 1.00 50.26 ? 275 ASN A N   1 
ATOM   3814 C CA  . ASN C 3 275 ? 205.170 180.057 187.271 1.00 50.26 ? 275 ASN A CA  1 
ATOM   3815 C C   . ASN C 3 275 ? 203.669 180.151 187.031 1.00 50.26 ? 275 ASN A C   1 
ATOM   3816 O O   . ASN C 3 275 ? 203.224 180.602 185.965 1.00 50.26 ? 275 ASN A O   1 
ATOM   3817 C CB  . ASN C 3 275 ? 205.664 178.644 186.971 1.00 50.26 ? 275 ASN A CB  1 
ATOM   3818 C CG  . ASN C 3 275 ? 207.164 178.571 186.817 1.00 50.26 ? 275 ASN A CG  1 
ATOM   3819 O OD1 . ASN C 3 275 ? 207.694 178.706 185.716 1.00 50.26 ? 275 ASN A OD1 1 
ATOM   3820 N ND2 . ASN C 3 275 ? 207.860 178.347 187.922 1.00 50.26 ? 275 ASN A ND2 1 
ATOM   3821 N N   . ALA C 3 276 ? 202.875 179.712 188.008 1.00 49.56 ? 276 ALA A N   1 
ATOM   3822 C CA  . ALA C 3 276 ? 201.426 179.813 187.885 1.00 49.56 ? 276 ALA A CA  1 
ATOM   3823 C C   . ALA C 3 276 ? 200.985 181.263 187.755 1.00 49.56 ? 276 ALA A C   1 
ATOM   3824 O O   . ALA C 3 276 ? 200.077 181.575 186.977 1.00 49.56 ? 276 ALA A O   1 
ATOM   3825 C CB  . ALA C 3 276 ? 200.749 179.150 189.083 1.00 49.56 ? 276 ALA A CB  1 
ATOM   3826 N N   . TYR C 3 277 ? 201.608 182.165 188.515 1.00 49.03 ? 277 TYR A N   1 
ATOM   3827 C CA  . TYR C 3 277 ? 201.270 183.580 188.392 1.00 49.03 ? 277 TYR A CA  1 
ATOM   3828 C C   . TYR C 3 277 ? 201.692 184.137 187.040 1.00 49.03 ? 277 TYR A C   1 
ATOM   3829 O O   . TYR C 3 277 ? 200.978 184.961 186.451 1.00 49.03 ? 277 TYR A O   1 
ATOM   3830 C CB  . TYR C 3 277 ? 201.919 184.380 189.516 1.00 49.03 ? 277 TYR A CB  1 
ATOM   3831 C CG  . TYR C 3 277 ? 201.634 185.858 189.440 1.00 49.03 ? 277 TYR A CG  1 
ATOM   3832 C CD1 . TYR C 3 277 ? 200.348 186.343 189.611 1.00 49.03 ? 277 TYR A CD1 1 
ATOM   3833 C CD2 . TYR C 3 277 ? 202.646 186.767 189.206 1.00 49.03 ? 277 TYR A CD2 1 
ATOM   3834 C CE1 . TYR C 3 277 ? 200.082 187.690 189.545 1.00 49.03 ? 277 TYR A CE1 1 
ATOM   3835 C CE2 . TYR C 3 277 ? 202.388 188.116 189.137 1.00 49.03 ? 277 TYR A CE2 1 
ATOM   3836 C CZ  . TYR C 3 277 ? 201.107 188.571 189.310 1.00 49.03 ? 277 TYR A CZ  1 
ATOM   3837 O OH  . TYR C 3 277 ? 200.845 189.915 189.241 1.00 49.03 ? 277 TYR A OH  1 
ATOM   3838 N N   . ILE C 3 278 ? 202.857 183.718 186.542 1.00 48.06 ? 278 ILE A N   1 
ATOM   3839 C CA  . ILE C 3 278 ? 203.345 184.233 185.267 1.00 48.06 ? 278 ILE A CA  1 
ATOM   3840 C C   . ILE C 3 278 ? 202.387 183.860 184.147 1.00 48.06 ? 278 ILE A C   1 
ATOM   3841 O O   . ILE C 3 278 ? 201.906 184.726 183.405 1.00 48.06 ? 278 ILE A O   1 
ATOM   3842 C CB  . ILE C 3 278 ? 204.764 183.715 184.984 1.00 48.06 ? 278 ILE A CB  1 
ATOM   3843 C CG1 . ILE C 3 278 ? 205.795 184.493 185.792 1.00 48.06 ? 278 ILE A CG1 1 
ATOM   3844 C CG2 . ILE C 3 278 ? 205.084 183.818 183.504 1.00 48.06 ? 278 ILE A CG2 1 
ATOM   3845 C CD1 . ILE C 3 278 ? 207.192 183.943 185.662 1.00 48.06 ? 278 ILE A CD1 1 
ATOM   3846 N N   . GLN C 3 279 ? 202.046 182.573 184.054 1.00 48.94 ? 279 GLN A N   1 
ATOM   3847 C CA  . GLN C 3 279 ? 201.234 182.093 182.941 1.00 48.94 ? 279 GLN A CA  1 
ATOM   3848 C C   . GLN C 3 279 ? 199.861 182.746 182.903 1.00 48.94 ? 279 GLN A C   1 
ATOM   3849 O O   . GLN C 3 279 ? 199.214 182.746 181.851 1.00 48.94 ? 279 GLN A O   1 
ATOM   3850 C CB  . GLN C 3 279 ? 201.091 180.573 183.019 1.00 48.94 ? 279 GLN A CB  1 
ATOM   3851 C CG  . GLN C 3 279 ? 200.452 179.935 181.802 1.00 48.94 ? 279 GLN A CG  1 
ATOM   3852 C CD  . GLN C 3 279 ? 200.470 178.423 181.862 1.00 48.94 ? 279 GLN A CD  1 
ATOM   3853 O OE1 . GLN C 3 279 ? 200.471 177.834 182.942 1.00 48.94 ? 279 GLN A OE1 1 
ATOM   3854 N NE2 . GLN C 3 279 ? 200.481 177.785 180.698 1.00 48.94 ? 279 GLN A NE2 1 
ATOM   3855 N N   . LYS C 3 280 ? 199.411 183.319 184.014 1.00 49.52 ? 280 LYS A N   1 
ATOM   3856 C CA  . LYS C 3 280 ? 198.075 183.889 184.102 1.00 49.52 ? 280 LYS A CA  1 
ATOM   3857 C C   . LYS C 3 280 ? 198.050 185.407 184.034 1.00 49.52 ? 280 LYS A C   1 
ATOM   3858 O O   . LYS C 3 280 ? 197.046 185.972 183.594 1.00 49.52 ? 280 LYS A O   1 
ATOM   3859 C CB  . LYS C 3 280 ? 197.403 183.440 185.403 1.00 49.52 ? 280 LYS A CB  1 
ATOM   3860 C CG  . LYS C 3 280 ? 195.892 183.574 185.412 1.00 49.52 ? 280 LYS A CG  1 
ATOM   3861 C CD  . LYS C 3 280 ? 195.258 182.477 186.247 1.00 49.52 ? 280 LYS A CD  1 
ATOM   3862 C CE  . LYS C 3 280 ? 195.873 182.416 187.631 1.00 49.52 ? 280 LYS A CE  1 
ATOM   3863 N NZ  . LYS C 3 280 ? 195.318 181.293 188.434 1.00 49.52 ? 280 LYS A NZ  1 
ATOM   3864 N N   . TYR C 3 281 ? 199.117 186.092 184.455 1.00 49.18 ? 281 TYR A N   1 
ATOM   3865 C CA  . TYR C 3 281 ? 199.066 187.542 184.559 1.00 49.18 ? 281 TYR A CA  1 
ATOM   3866 C C   . TYR C 3 281 ? 200.195 188.284 183.859 1.00 49.18 ? 281 TYR A C   1 
ATOM   3867 O O   . TYR C 3 281 ? 200.178 189.519 183.856 1.00 49.18 ? 281 TYR A O   1 
ATOM   3868 C CB  . TYR C 3 281 ? 199.054 187.969 186.033 1.00 49.18 ? 281 TYR A CB  1 
ATOM   3869 C CG  . TYR C 3 281 ? 197.739 187.739 186.730 1.00 49.18 ? 281 TYR A CG  1 
ATOM   3870 C CD1 . TYR C 3 281 ? 196.708 188.653 186.624 1.00 49.18 ? 281 TYR A CD1 1 
ATOM   3871 C CD2 . TYR C 3 281 ? 197.530 186.603 187.495 1.00 49.18 ? 281 TYR A CD2 1 
ATOM   3872 C CE1 . TYR C 3 281 ? 195.506 188.444 187.260 1.00 49.18 ? 281 TYR A CE1 1 
ATOM   3873 C CE2 . TYR C 3 281 ? 196.334 186.383 188.130 1.00 49.18 ? 281 TYR A CE2 1 
ATOM   3874 C CZ  . TYR C 3 281 ? 195.326 187.306 188.012 1.00 49.18 ? 281 TYR A CZ  1 
ATOM   3875 O OH  . TYR C 3 281 ? 194.126 187.092 188.649 1.00 49.18 ? 281 TYR A OH  1 
ATOM   3876 N N   . LEU C 3 282 ? 201.169 187.598 183.279 1.00 48.46 ? 282 LEU A N   1 
ATOM   3877 C CA  . LEU C 3 282 ? 202.308 188.292 182.705 1.00 48.46 ? 282 LEU A CA  1 
ATOM   3878 C C   . LEU C 3 282 ? 202.350 188.113 181.193 1.00 48.46 ? 282 LEU A C   1 
ATOM   3879 O O   . LEU C 3 282 ? 201.758 187.170 180.655 1.00 48.46 ? 282 LEU A O   1 
ATOM   3880 C CB  . LEU C 3 282 ? 203.616 187.790 183.333 1.00 48.46 ? 282 LEU A CB  1 
ATOM   3881 C CG  . LEU C 3 282 ? 203.782 188.151 184.809 1.00 48.46 ? 282 LEU A CG  1 
ATOM   3882 C CD1 . LEU C 3 282 ? 205.227 188.006 185.241 1.00 48.46 ? 282 LEU A CD1 1 
ATOM   3883 C CD2 . LEU C 3 282 ? 203.285 189.559 185.076 1.00 48.46 ? 282 LEU A CD2 1 
ATOM   3884 N N   . PRO C 3 283 ? 203.013 189.020 180.474 1.00 47.19 ? 283 PRO A N   1 
ATOM   3885 C CA  . PRO C 3 283 ? 203.131 188.868 179.017 1.00 47.19 ? 283 PRO A CA  1 
ATOM   3886 C C   . PRO C 3 283 ? 203.777 187.541 178.647 1.00 47.19 ? 283 PRO A C   1 
ATOM   3887 O O   . PRO C 3 283 ? 204.808 187.157 179.201 1.00 47.19 ? 283 PRO A O   1 
ATOM   3888 C CB  . PRO C 3 283 ? 204.007 190.056 178.610 1.00 47.19 ? 283 PRO A CB  1 
ATOM   3889 C CG  . PRO C 3 283 ? 203.776 191.064 179.667 1.00 47.19 ? 283 PRO A CG  1 
ATOM   3890 C CD  . PRO C 3 283 ? 203.563 190.302 180.939 1.00 47.19 ? 283 PRO A CD  1 
ATOM   3891 N N   . THR C 3 284 ? 203.164 186.843 177.694 1.00 45.32 ? 284 THR A N   1 
ATOM   3892 C CA  . THR C 3 284 ? 203.599 185.503 177.338 1.00 45.32 ? 284 THR A CA  1 
ATOM   3893 C C   . THR C 3 284 ? 203.250 185.242 175.881 1.00 45.32 ? 284 THR A C   1 
ATOM   3894 O O   . THR C 3 284 ? 202.266 185.769 175.360 1.00 45.32 ? 284 THR A O   1 
ATOM   3895 C CB  . THR C 3 284 ? 202.950 184.451 178.246 1.00 45.32 ? 284 THR A CB  1 
ATOM   3896 O OG1 . THR C 3 284 ? 203.138 184.821 179.616 1.00 45.32 ? 284 THR A OG1 1 
ATOM   3897 C CG2 . THR C 3 284 ? 203.575 183.081 178.027 1.00 45.32 ? 284 THR A CG2 1 
ATOM   3898 N N   . ALA C 3 285 ? 204.071 184.425 175.228 1.00 45.98 ? 285 ALA A N   1 
ATOM   3899 C CA  . ALA C 3 285 ? 203.852 184.075 173.836 1.00 45.98 ? 285 ALA A CA  1 
ATOM   3900 C C   . ALA C 3 285 ? 204.311 182.645 173.605 1.00 45.98 ? 285 ALA A C   1 
ATOM   3901 O O   . ALA C 3 285 ? 205.183 182.136 174.310 1.00 45.98 ? 285 ALA A O   1 
ATOM   3902 C CB  . ALA C 3 285 ? 204.588 185.029 172.892 1.00 45.98 ? 285 ALA A CB  1 
ATOM   3903 N N   . GLU C 3 286 ? 203.700 181.998 172.618 1.00 50.56 ? 286 GLU A N   1 
ATOM   3904 C CA  . GLU C 3 286 ? 204.012 180.618 172.289 1.00 50.56 ? 286 GLU A CA  1 
ATOM   3905 C C   . GLU C 3 286 ? 203.702 180.355 170.824 1.00 50.56 ? 286 GLU A C   1 
ATOM   3906 O O   . GLU C 3 286 ? 202.630 180.719 170.334 1.00 50.56 ? 286 GLU A O   1 
ATOM   3907 C CB  . GLU C 3 286 ? 203.220 179.659 173.176 1.00 50.56 ? 286 GLU A CB  1 
ATOM   3908 C CG  . GLU C 3 286 ? 203.117 178.253 172.630 1.00 50.56 ? 286 GLU A CG  1 
ATOM   3909 C CD  . GLU C 3 286 ? 202.032 177.449 173.314 1.00 50.56 ? 286 GLU A CD  1 
ATOM   3910 O OE1 . GLU C 3 286 ? 201.580 176.440 172.732 1.00 50.56 ? 286 GLU A OE1 1 
ATOM   3911 O OE2 . GLU C 3 286 ? 201.631 177.826 174.435 1.00 50.56 ? 286 GLU A OE2 1 
ATOM   3912 N N   . THR C 3 287 ? 204.645 179.727 170.129 1.00 50.84 ? 287 THR A N   1 
ATOM   3913 C CA  . THR C 3 287 ? 204.460 179.272 168.760 1.00 50.84 ? 287 THR A CA  1 
ATOM   3914 C C   . THR C 3 287 ? 204.915 177.825 168.659 1.00 50.84 ? 287 THR A C   1 
ATOM   3915 O O   . THR C 3 287 ? 205.543 177.284 169.571 1.00 50.84 ? 287 THR A O   1 
ATOM   3916 C CB  . THR C 3 287 ? 205.230 180.132 167.752 1.00 50.84 ? 287 THR A CB  1 
ATOM   3917 O OG1 . THR C 3 287 ? 206.619 179.786 167.793 1.00 50.84 ? 287 THR A OG1 1 
ATOM   3918 C CG2 . THR C 3 287 ? 205.053 181.614 168.040 1.00 50.84 ? 287 THR A CG2 1 
ATOM   3919 N N   . THR C 3 288 ? 204.595 177.193 167.534 1.00 53.52 ? 288 THR A N   1 
ATOM   3920 C CA  . THR C 3 288 ? 204.935 175.785 167.356 1.00 53.52 ? 288 THR A CA  1 
ATOM   3921 C C   . THR C 3 288 ? 205.015 175.479 165.872 1.00 53.52 ? 288 THR A C   1 
ATOM   3922 O O   . THR C 3 288 ? 204.046 175.707 165.141 1.00 53.52 ? 288 THR A O   1 
ATOM   3923 C CB  . THR C 3 288 ? 203.906 174.895 168.037 1.00 53.52 ? 288 THR A CB  1 
ATOM   3924 O OG1 . THR C 3 288 ? 204.155 174.875 169.447 1.00 53.52 ? 288 THR A OG1 1 
ATOM   3925 C CG2 . THR C 3 288 ? 203.986 173.485 167.499 1.00 53.52 ? 288 THR A CG2 1 
ATOM   3926 N N   . ARG C 3 289 ? 206.159 174.965 165.432 1.00 58.35 ? 289 ARG A N   1 
ATOM   3927 C CA  . ARG C 3 289 ? 206.363 174.550 164.053 1.00 58.35 ? 289 ARG A CA  1 
ATOM   3928 C C   . ARG C 3 289 ? 206.867 173.115 164.033 1.00 58.35 ? 289 ARG A C   1 
ATOM   3929 O O   . ARG C 3 289 ? 207.710 172.734 164.851 1.00 58.35 ? 289 ARG A O   1 
ATOM   3930 C CB  . ARG C 3 289 ? 207.360 175.471 163.330 1.00 58.35 ? 289 ARG A CB  1 
ATOM   3931 C CG  . ARG C 3 289 ? 207.243 175.438 161.819 1.00 58.35 ? 289 ARG A CG  1 
ATOM   3932 C CD  . ARG C 3 289 ? 208.425 176.110 161.132 1.00 58.35 ? 289 ARG A CD  1 
ATOM   3933 N NE  . ARG C 3 289 ? 208.398 177.565 161.237 1.00 58.35 ? 289 ARG A NE  1 
ATOM   3934 C CZ  . ARG C 3 289 ? 208.561 178.393 160.212 1.00 58.35 ? 289 ARG A CZ  1 
ATOM   3935 N NH1 . ARG C 3 289 ? 208.743 177.943 158.981 1.00 58.35 ? 289 ARG A NH1 1 
ATOM   3936 N NH2 . ARG C 3 289 ? 208.539 179.705 160.427 1.00 58.35 ? 289 ARG A NH2 1 
ATOM   3937 N N   . GLN C 3 290 ? 206.334 172.318 163.107 1.00 62.48 ? 290 GLN A N   1 
ATOM   3938 C CA  . GLN C 3 290 ? 206.795 170.953 162.872 1.00 62.48 ? 290 GLN A CA  1 
ATOM   3939 C C   . GLN C 3 290 ? 207.155 170.829 161.398 1.00 62.48 ? 290 GLN A C   1 
ATOM   3940 O O   . GLN C 3 290 ? 206.276 170.905 160.533 1.00 62.48 ? 290 GLN A O   1 
ATOM   3941 C CB  . GLN C 3 290 ? 205.733 169.926 163.265 1.00 62.48 ? 290 GLN A CB  1 
ATOM   3942 C CG  . GLN C 3 290 ? 204.311 170.313 162.908 1.00 62.48 ? 290 GLN A CG  1 
ATOM   3943 C CD  . GLN C 3 290 ? 203.587 170.997 164.048 1.00 62.48 ? 290 GLN A CD  1 
ATOM   3944 O OE1 . GLN C 3 290 ? 204.190 171.735 164.825 1.00 62.48 ? 290 GLN A OE1 1 
ATOM   3945 N NE2 . GLN C 3 290 ? 202.285 170.757 164.152 1.00 62.48 ? 290 GLN A NE2 1 
ATOM   3946 N N   . PHE C 3 291 ? 208.439 170.645 161.110 1.00 64.88 ? 291 PHE A N   1 
ATOM   3947 C CA  . PHE C 3 291 ? 208.874 170.558 159.728 1.00 64.88 ? 291 PHE A CA  1 
ATOM   3948 C C   . PHE C 3 291 ? 208.490 169.210 159.131 1.00 64.88 ? 291 PHE A C   1 
ATOM   3949 O O   . PHE C 3 291 ? 208.124 168.264 159.832 1.00 64.88 ? 291 PHE A O   1 
ATOM   3950 C CB  . PHE C 3 291 ? 210.385 170.739 159.613 1.00 64.88 ? 291 PHE A CB  1 
ATOM   3951 C CG  . PHE C 3 291 ? 210.987 171.542 160.719 1.00 64.88 ? 291 PHE A CG  1 
ATOM   3952 C CD1 . PHE C 3 291 ? 210.852 172.917 160.749 1.00 64.88 ? 291 PHE A CD1 1 
ATOM   3953 C CD2 . PHE C 3 291 ? 211.695 170.923 161.730 1.00 64.88 ? 291 PHE A CD2 1 
ATOM   3954 C CE1 . PHE C 3 291 ? 211.414 173.657 161.768 1.00 64.88 ? 291 PHE A CE1 1 
ATOM   3955 C CE2 . PHE C 3 291 ? 212.256 171.655 162.750 1.00 64.88 ? 291 PHE A CE2 1 
ATOM   3956 C CZ  . PHE C 3 291 ? 212.116 173.024 162.770 1.00 64.88 ? 291 PHE A CZ  1 
ATOM   3957 N N   . LEU C 3 292 ? 208.578 169.133 157.810 1.00 70.21 ? 292 LEU A N   1 
ATOM   3958 C CA  . LEU C 3 292 ? 208.541 167.842 157.154 1.00 70.21 ? 292 LEU A CA  1 
ATOM   3959 C C   . LEU C 3 292 ? 209.834 167.090 157.451 1.00 70.21 ? 292 LEU A C   1 
ATOM   3960 O O   . LEU C 3 292 ? 210.828 167.667 157.898 1.00 70.21 ? 292 LEU A O   1 
ATOM   3961 C CB  . LEU C 3 292 ? 208.348 168.006 155.647 1.00 70.21 ? 292 LEU A CB  1 
ATOM   3962 C CG  . LEU C 3 292 ? 206.911 168.145 155.138 1.00 70.21 ? 292 LEU A CG  1 
ATOM   3963 C CD1 . LEU C 3 292 ? 206.307 169.483 155.534 1.00 70.21 ? 292 LEU A CD1 1 
ATOM   3964 C CD2 . LEU C 3 292 ? 206.866 167.968 153.628 1.00 70.21 ? 292 LEU A CD2 1 
ATOM   3965 N N   . MET C 3 293 ? 209.814 165.786 157.180 1.00 74.98 ? 293 MET A N   1 
ATOM   3966 C CA  . MET C 3 293 ? 210.886 164.878 157.596 1.00 74.98 ? 293 MET A CA  1 
ATOM   3967 C C   . MET C 3 293 ? 211.114 164.961 159.104 1.00 74.98 ? 293 MET A C   1 
ATOM   3968 O O   . MET C 3 293 ? 212.247 164.911 159.586 1.00 74.98 ? 293 MET A O   1 
ATOM   3969 C CB  . MET C 3 293 ? 212.186 165.139 156.829 1.00 74.98 ? 293 MET A CB  1 
ATOM   3970 C CG  . MET C 3 293 ? 212.011 165.757 155.450 1.00 74.98 ? 293 MET A CG  1 
ATOM   3971 S SD  . MET C 3 293 ? 211.987 164.523 154.135 1.00 74.98 ? 293 MET A SD  1 
ATOM   3972 C CE  . MET C 3 293 ? 213.708 164.518 153.642 1.00 74.98 ? 293 MET A CE  1 
ATOM   3973 N N   . SER C 3 294 ? 210.021 165.090 159.853 1.00 73.27 ? 294 SER A N   1 
ATOM   3974 C CA  . SER C 3 294 ? 210.067 165.141 161.307 1.00 73.27 ? 294 SER A CA  1 
ATOM   3975 C C   . SER C 3 294 ? 208.757 164.591 161.851 1.00 73.27 ? 294 SER A C   1 
ATOM   3976 O O   . SER C 3 294 ? 207.762 164.484 161.130 1.00 73.27 ? 294 SER A O   1 
ATOM   3977 C CB  . SER C 3 294 ? 210.310 166.566 161.817 1.00 73.27 ? 294 SER A CB  1 
ATOM   3978 O OG  . SER C 3 294 ? 209.132 167.348 161.721 1.00 73.27 ? 294 SER A OG  1 
ATOM   3979 N N   . ASP C 3 295 ? 208.765 164.244 163.135 1.00 72.61 ? 295 ASP A N   1 
ATOM   3980 C CA  . ASP C 3 295 ? 207.623 163.589 163.754 1.00 72.61 ? 295 ASP A CA  1 
ATOM   3981 C C   . ASP C 3 295 ? 206.979 164.380 164.882 1.00 72.61 ? 295 ASP A C   1 
ATOM   3982 O O   . ASP C 3 295 ? 205.775 164.234 165.100 1.00 72.61 ? 295 ASP A O   1 
ATOM   3983 C CB  . ASP C 3 295 ? 208.030 162.210 164.293 1.00 72.61 ? 295 ASP A CB  1 
ATOM   3984 C CG  . ASP C 3 295 ? 208.202 161.184 163.192 1.00 72.61 ? 295 ASP A CG  1 
ATOM   3985 O OD1 . ASP C 3 295 ? 209.246 161.215 162.508 1.00 72.61 ? 295 ASP A OD1 1 
ATOM   3986 O OD2 . ASP C 3 295 ? 207.294 160.346 163.011 1.00 72.61 ? 295 ASP A OD2 1 
ATOM   3987 N N   . LYS C 3 296 ? 207.733 165.202 165.602 1.00 64.31 ? 296 LYS A N   1 
ATOM   3988 C CA  . LYS C 3 296 ? 207.194 165.924 166.742 1.00 64.31 ? 296 LYS A CA  1 
ATOM   3989 C C   . LYS C 3 296 ? 207.579 167.393 166.660 1.00 64.31 ? 296 LYS A C   1 
ATOM   3990 O O   . LYS C 3 296 ? 208.611 167.737 166.077 1.00 64.31 ? 296 LYS A O   1 
ATOM   3991 C CB  . LYS C 3 296 ? 207.698 165.315 168.057 1.00 64.31 ? 296 LYS A CB  1 
ATOM   3992 C CG  . LYS C 3 296 ? 206.961 164.050 168.467 1.00 64.31 ? 296 LYS A CG  1 
ATOM   3993 C CD  . LYS C 3 296 ? 207.433 163.548 169.821 1.00 64.31 ? 296 LYS A CD  1 
ATOM   3994 C CE  . LYS C 3 296 ? 206.659 162.315 170.252 1.00 64.31 ? 296 LYS A CE  1 
ATOM   3995 N NZ  . LYS C 3 296 ? 207.132 161.795 171.564 1.00 64.31 ? 296 LYS A NZ  1 
ATOM   3996 N N   . PRO C 3 297 ? 206.768 168.279 167.228 1.00 60.26 ? 297 PRO A N   1 
ATOM   3997 C CA  . PRO C 3 297 ? 206.932 169.712 166.969 1.00 60.26 ? 297 PRO A CA  1 
ATOM   3998 C C   . PRO C 3 297 ? 208.056 170.350 167.772 1.00 60.26 ? 297 PRO A C   1 
ATOM   3999 O O   . PRO C 3 297 ? 208.519 169.827 168.786 1.00 60.26 ? 297 PRO A O   1 
ATOM   4000 C CB  . PRO C 3 297 ? 205.578 170.291 167.389 1.00 60.26 ? 297 PRO A CB  1 
ATOM   4001 C CG  . PRO C 3 297 ? 205.118 169.370 168.457 1.00 60.26 ? 297 PRO A CG  1 
ATOM   4002 C CD  . PRO C 3 297 ? 205.553 168.003 168.013 1.00 60.26 ? 297 PRO A CD  1 
ATOM   4003 N N   . LEU C 3 298 ? 208.479 171.519 167.291 1.00 55.07 ? 298 LEU A N   1 
ATOM   4004 C CA  . LEU C 3 298 ? 209.407 172.389 168.001 1.00 55.07 ? 298 LEU A CA  1 
ATOM   4005 C C   . LEU C 3 298 ? 208.614 173.465 168.727 1.00 55.07 ? 298 LEU A C   1 
ATOM   4006 O O   . LEU C 3 298 ? 207.759 174.124 168.126 1.00 55.07 ? 298 LEU A O   1 
ATOM   4007 C CB  . LEU C 3 298 ? 210.414 173.019 167.036 1.00 55.07 ? 298 LEU A CB  1 
ATOM   4008 C CG  . LEU C 3 298 ? 211.346 174.121 167.550 1.00 55.07 ? 298 LEU A CG  1 
ATOM   4009 C CD1 . LEU C 3 298 ? 212.721 174.004 166.928 1.00 55.07 ? 298 LEU A CD1 1 
ATOM   4010 C CD2 . LEU C 3 298 ? 210.770 175.493 167.256 1.00 55.07 ? 298 LEU A CD2 1 
ATOM   4011 N N   . HIS C 3 299 ? 208.901 173.647 170.010 1.00 49.04 ? 299 HIS A N   1 
ATOM   4012 C CA  . HIS C 3 299 ? 208.111 174.498 170.883 1.00 49.04 ? 299 HIS A CA  1 
ATOM   4013 C C   . HIS C 3 299 ? 209.000 175.588 171.457 1.00 49.04 ? 299 HIS A C   1 
ATOM   4014 O O   . HIS C 3 299 ? 210.092 175.302 171.956 1.00 49.04 ? 299 HIS A O   1 
ATOM   4015 C CB  . HIS C 3 299 ? 207.481 173.663 172.001 1.00 49.04 ? 299 HIS A CB  1 
ATOM   4016 C CG  . HIS C 3 299 ? 206.445 174.386 172.800 1.00 49.04 ? 299 HIS A CG  1 
ATOM   4017 N ND1 . HIS C 3 299 ? 205.978 173.914 174.006 1.00 49.04 ? 299 HIS A ND1 1 
ATOM   4018 C CD2 . HIS C 3 299 ? 205.785 175.544 172.568 1.00 49.04 ? 299 HIS A CD2 1 
ATOM   4019 C CE1 . HIS C 3 299 ? 205.073 174.748 174.483 1.00 49.04 ? 299 HIS A CE1 1 
ATOM   4020 N NE2 . HIS C 3 299 ? 204.938 175.747 173.630 1.00 49.04 ? 299 HIS A NE2 1 
ATOM   4021 N N   . LEU C 3 300 ? 208.536 176.832 171.386 1.00 45.30 ? 300 LEU A N   1 
ATOM   4022 C CA  . LEU C 3 300 ? 209.270 177.981 171.898 1.00 45.30 ? 300 LEU A CA  1 
ATOM   4023 C C   . LEU C 3 300 ? 208.329 178.860 172.704 1.00 45.30 ? 300 LEU A C   1 
ATOM   4024 O O   . LEU C 3 300 ? 207.242 179.204 172.230 1.00 45.30 ? 300 LEU A O   1 
ATOM   4025 C CB  . LEU C 3 300 ? 209.899 178.781 170.760 1.00 45.30 ? 300 LEU A CB  1 
ATOM   4026 C CG  . LEU C 3 300 ? 210.159 180.256 171.037 1.00 45.30 ? 300 LEU A CG  1 
ATOM   4027 C CD1 . LEU C 3 300 ? 211.342 180.430 171.963 1.00 45.30 ? 300 LEU A CD1 1 
ATOM   4028 C CD2 . LEU C 3 300 ? 210.396 180.984 169.732 1.00 45.30 ? 300 LEU A CD2 1 
ATOM   4029 N N   . GLU C 3 301 ? 208.743 179.223 173.914 1.00 44.66 ? 301 GLU A N   1 
ATOM   4030 C CA  . GLU C 3 301 ? 207.897 179.984 174.821 1.00 44.66 ? 301 GLU A CA  1 
ATOM   4031 C C   . GLU C 3 301 ? 208.742 181.003 175.565 1.00 44.66 ? 301 GLU A C   1 
ATOM   4032 O O   . GLU C 3 301 ? 209.778 180.652 176.136 1.00 44.66 ? 301 GLU A O   1 
ATOM   4033 C CB  . GLU C 3 301 ? 207.187 179.051 175.807 1.00 44.66 ? 301 GLU A CB  1 
ATOM   4034 C CG  . GLU C 3 301 ? 206.247 179.743 176.786 1.00 44.66 ? 301 GLU A CG  1 
ATOM   4035 C CD  . GLU C 3 301 ? 206.902 180.067 178.118 1.00 44.66 ? 301 GLU A CD  1 
ATOM   4036 O OE1 . GLU C 3 301 ? 208.097 179.748 178.289 1.00 44.66 ? 301 GLU A OE1 1 
ATOM   4037 O OE2 . GLU C 3 301 ? 206.215 180.628 179.000 1.00 44.66 ? 301 GLU A OE2 1 
ATOM   4038 N N   . ALA C 3 302 ? 208.294 182.253 175.571 1.00 40.37 ? 302 ALA A N   1 
ATOM   4039 C CA  . ALA C 3 302 ? 209.002 183.338 176.229 1.00 40.37 ? 302 ALA A CA  1 
ATOM   4040 C C   . ALA C 3 302 ? 208.040 184.120 177.107 1.00 40.37 ? 302 ALA A C   1 
ATOM   4041 O O   . ALA C 3 302 ? 206.821 184.039 176.947 1.00 40.37 ? 302 ALA A O   1 
ATOM   4042 C CB  . ALA C 3 302 ? 209.659 184.272 175.209 1.00 40.37 ? 302 ALA A CB  1 
ATOM   4043 N N   . SER C 3 303 ? 208.599 184.883 178.046 1.00 42.55 ? 303 SER A N   1 
ATOM   4044 C CA  . SER C 3 303 ? 207.774 185.692 178.932 1.00 42.55 ? 303 SER A CA  1 
ATOM   4045 C C   . SER C 3 303 ? 208.634 186.743 179.616 1.00 42.55 ? 303 SER A C   1 
ATOM   4046 O O   . SER C 3 303 ? 209.739 186.445 180.068 1.00 42.55 ? 303 SER A O   1 
ATOM   4047 C CB  . SER C 3 303 ? 207.078 184.827 179.986 1.00 42.55 ? 303 SER A CB  1 
ATOM   4048 O OG  . SER C 3 303 ? 208.021 184.253 180.871 1.00 42.55 ? 303 SER A OG  1 
ATOM   4049 N N   . LEU C 3 304 ? 208.115 187.965 179.689 1.00 44.16 ? 304 LEU A N   1 
ATOM   4050 C CA  . LEU C 3 304 ? 208.743 189.038 180.443 1.00 44.16 ? 304 LEU A CA  1 
ATOM   4051 C C   . LEU C 3 304 ? 208.218 189.039 181.871 1.00 44.16 ? 304 LEU A C   1 
ATOM   4052 O O   . LEU C 3 304 ? 207.071 188.666 182.131 1.00 44.16 ? 304 LEU A O   1 
ATOM   4053 C CB  . LEU C 3 304 ? 208.471 190.396 179.800 1.00 44.16 ? 304 LEU A CB  1 
ATOM   4054 C CG  . LEU C 3 304 ? 208.809 190.602 178.329 1.00 44.16 ? 304 LEU A CG  1 
ATOM   4055 C CD1 . LEU C 3 304 ? 208.651 192.056 177.971 1.00 44.16 ? 304 LEU A CD1 1 
ATOM   4056 C CD2 . LEU C 3 304 ? 210.220 190.141 178.053 1.00 44.16 ? 304 LEU A CD2 1 
ATOM   4057 N N   . ASP C 3 305 ? 209.065 189.474 182.800 1.00 47.90 ? 305 ASP A N   1 
ATOM   4058 C CA  . ASP C 3 305 ? 208.716 189.444 184.212 1.00 47.90 ? 305 ASP A CA  1 
ATOM   4059 C C   . ASP C 3 305 ? 207.880 190.633 184.665 1.00 47.90 ? 305 ASP A C   1 
ATOM   4060 O O   . ASP C 3 305 ? 207.305 190.582 185.756 1.00 47.90 ? 305 ASP A O   1 
ATOM   4061 C CB  . ASP C 3 305 ? 209.983 189.364 185.068 1.00 47.90 ? 305 ASP A CB  1 
ATOM   4062 C CG  . ASP C 3 305 ? 211.042 188.474 184.455 1.00 47.90 ? 305 ASP A CG  1 
ATOM   4063 O OD1 . ASP C 3 305 ? 210.678 187.429 183.877 1.00 47.90 ? 305 ASP A OD1 1 
ATOM   4064 O OD2 . ASP C 3 305 ? 212.238 188.811 184.561 1.00 47.90 ? 305 ASP A OD2 1 
ATOM   4065 N N   . LYS C 3 306 ? 207.796 191.695 183.870 1.00 49.09 ? 306 LYS A N   1 
ATOM   4066 C CA  . LYS C 3 306 ? 207.019 192.868 184.240 1.00 49.09 ? 306 LYS A CA  1 
ATOM   4067 C C   . LYS C 3 306 ? 206.355 193.445 183.002 1.00 49.09 ? 306 LYS A C   1 
ATOM   4068 O O   . LYS C 3 306 ? 206.827 193.252 181.879 1.00 49.09 ? 306 LYS A O   1 
ATOM   4069 C CB  . LYS C 3 306 ? 207.885 193.942 184.909 1.00 49.09 ? 306 LYS A CB  1 
ATOM   4070 C CG  . LYS C 3 306 ? 208.524 193.517 186.218 1.00 49.09 ? 306 LYS A CG  1 
ATOM   4071 C CD  . LYS C 3 306 ? 209.673 194.434 186.602 1.00 49.09 ? 306 LYS A CD  1 
ATOM   4072 C CE  . LYS C 3 306 ? 209.235 195.882 186.636 1.00 49.09 ? 306 LYS A CE  1 
ATOM   4073 N NZ  . LYS C 3 306 ? 210.263 196.750 187.271 1.00 49.09 ? 306 LYS A NZ  1 
ATOM   4074 N N   . GLU C 3 307 ? 205.251 194.154 183.214 1.00 49.47 ? 307 GLU A N   1 
ATOM   4075 C CA  . GLU C 3 307 ? 204.566 194.819 182.117 1.00 49.47 ? 307 GLU A CA  1 
ATOM   4076 C C   . GLU C 3 307 ? 205.029 196.255 181.918 1.00 49.47 ? 307 GLU A C   1 
ATOM   4077 O O   . GLU C 3 307 ? 204.853 196.804 180.826 1.00 49.47 ? 307 GLU A O   1 
ATOM   4078 C CB  . GLU C 3 307 ? 203.053 194.790 182.348 1.00 49.47 ? 307 GLU A CB  1 
ATOM   4079 C CG  . GLU C 3 307 ? 202.228 195.332 181.195 1.00 49.47 ? 307 GLU A CG  1 
ATOM   4080 C CD  . GLU C 3 307 ? 200.898 194.625 181.047 1.00 49.47 ? 307 GLU A CD  1 
ATOM   4081 O OE1 . GLU C 3 307 ? 200.445 193.997 182.026 1.00 49.47 ? 307 GLU A OE1 1 
ATOM   4082 O OE2 . GLU C 3 307 ? 200.304 194.699 179.951 1.00 49.47 ? 307 GLU A OE2 1 
ATOM   4083 N N   . ILE C 3 308 ? 205.635 196.865 182.933 1.00 48.23 ? 308 ILE A N   1 
ATOM   4084 C CA  . ILE C 3 308 ? 206.078 198.251 182.884 1.00 48.23 ? 308 ILE A CA  1 
ATOM   4085 C C   . ILE C 3 308 ? 207.560 198.298 183.221 1.00 48.23 ? 308 ILE A C   1 
ATOM   4086 O O   . ILE C 3 308 ? 207.991 197.709 184.218 1.00 48.23 ? 308 ILE A O   1 
ATOM   4087 C CB  . ILE C 3 308 ? 205.280 199.134 183.859 1.00 48.23 ? 308 ILE A CB  1 
ATOM   4088 C CG1 . ILE C 3 308 ? 203.787 199.064 183.537 1.00 48.23 ? 308 ILE A CG1 1 
ATOM   4089 C CG2 . ILE C 3 308 ? 205.787 200.567 183.816 1.00 48.23 ? 308 ILE A CG2 1 
ATOM   4090 C CD1 . ILE C 3 308 ? 203.007 200.299 183.927 1.00 48.23 ? 308 ILE A CD1 1 
ATOM   4091 N N   . TYR C 3 309 ? 208.337 198.997 182.397 1.00 47.66 ? 309 TYR A N   1 
ATOM   4092 C CA  . TYR C 3 309 ? 209.765 199.161 182.618 1.00 47.66 ? 309 TYR A CA  1 
ATOM   4093 C C   . TYR C 3 309 ? 210.125 200.631 182.494 1.00 47.66 ? 309 TYR A C   1 
ATOM   4094 O O   . TYR C 3 309 ? 209.552 201.352 181.674 1.00 47.66 ? 309 TYR A O   1 
ATOM   4095 C CB  . TYR C 3 309 ? 210.588 198.347 181.627 1.00 47.66 ? 309 TYR A CB  1 
ATOM   4096 C CG  . TYR C 3 309 ? 210.552 196.864 181.877 1.00 47.66 ? 309 TYR A CG  1 
ATOM   4097 C CD1 . TYR C 3 309 ? 211.174 196.313 182.984 1.00 47.66 ? 309 TYR A CD1 1 
ATOM   4098 C CD2 . TYR C 3 309 ? 209.906 196.012 181.000 1.00 47.66 ? 309 TYR A CD2 1 
ATOM   4099 C CE1 . TYR C 3 309 ? 211.144 194.954 183.213 1.00 47.66 ? 309 TYR A CE1 1 
ATOM   4100 C CE2 . TYR C 3 309 ? 209.871 194.659 181.219 1.00 47.66 ? 309 TYR A CE2 1 
ATOM   4101 C CZ  . TYR C 3 309 ? 210.489 194.134 182.328 1.00 47.66 ? 309 TYR A CZ  1 
ATOM   4102 O OH  . TYR C 3 309 ? 210.455 192.780 182.547 1.00 47.66 ? 309 TYR A OH  1 
ATOM   4103 N N   . TYR C 3 310 ? 211.074 201.069 183.312 1.00 50.09 ? 310 TYR A N   1 
ATOM   4104 C CA  . TYR C 3 310 ? 211.497 202.458 183.346 1.00 50.09 ? 310 TYR A CA  1 
ATOM   4105 C C   . TYR C 3 310 ? 212.720 202.660 182.467 1.00 50.09 ? 310 TYR A C   1 
ATOM   4106 O O   . TYR C 3 310 ? 213.467 201.719 182.187 1.00 50.09 ? 310 TYR A O   1 
ATOM   4107 C CB  . TYR C 3 310 ? 211.801 202.892 184.775 1.00 50.09 ? 310 TYR A CB  1 
ATOM   4108 C CG  . TYR C 3 310 ? 210.708 202.523 185.740 1.00 50.09 ? 310 TYR A CG  1 
ATOM   4109 C CD1 . TYR C 3 310 ? 209.506 203.213 185.750 1.00 50.09 ? 310 TYR A CD1 1 
ATOM   4110 C CD2 . TYR C 3 310 ? 210.870 201.479 186.632 1.00 50.09 ? 310 TYR A CD2 1 
ATOM   4111 C CE1 . TYR C 3 310 ? 208.501 202.878 186.624 1.00 50.09 ? 310 TYR A CE1 1 
ATOM   4112 C CE2 . TYR C 3 310 ? 209.868 201.135 187.513 1.00 50.09 ? 310 TYR A CE2 1 
ATOM   4113 C CZ  . TYR C 3 310 ? 208.686 201.838 187.504 1.00 50.09 ? 310 TYR A CZ  1 
ATOM   4114 O OH  . TYR C 3 310 ? 207.682 201.502 188.380 1.00 50.09 ? 310 TYR A OH  1 
ATOM   4115 N N   . HIS C 3 311 ? 212.911 203.898 182.022 1.00 49.78 ? 311 HIS A N   1 
ATOM   4116 C CA  . HIS C 3 311 ? 214.021 204.212 181.135 1.00 49.78 ? 311 HIS A CA  1 
ATOM   4117 C C   . HIS C 3 311 ? 215.345 203.912 181.820 1.00 49.78 ? 311 HIS A C   1 
ATOM   4118 O O   . HIS C 3 311 ? 215.726 204.595 182.775 1.00 49.78 ? 311 HIS A O   1 
ATOM   4119 C CB  . HIS C 3 311 ? 213.969 205.676 180.701 1.00 49.78 ? 311 HIS A CB  1 
ATOM   4120 C CG  . HIS C 3 311 ? 212.890 205.977 179.712 1.00 49.78 ? 311 HIS A CG  1 
ATOM   4121 N ND1 . HIS C 3 311 ? 211.620 206.353 180.089 1.00 49.78 ? 311 HIS A ND1 1 
ATOM   4122 C CD2 . HIS C 3 311 ? 212.892 205.965 178.359 1.00 49.78 ? 311 HIS A CD2 1 
ATOM   4123 C CE1 . HIS C 3 311 ? 210.886 206.557 179.011 1.00 49.78 ? 311 HIS A CE1 1 
ATOM   4124 N NE2 . HIS C 3 311 ? 211.634 206.326 177.948 1.00 49.78 ? 311 HIS A NE2 1 
ATOM   4125 N N   . GLY C 3 312 ? 216.053 202.888 181.339 1.00 49.89 ? 312 GLY A N   1 
ATOM   4126 C CA  . GLY C 3 312 ? 217.339 202.489 181.869 1.00 49.89 ? 312 GLY A CA  1 
ATOM   4127 C C   . GLY C 3 312 ? 217.299 201.220 182.696 1.00 49.89 ? 312 GLY A C   1 
ATOM   4128 O O   . GLY C 3 312 ? 218.324 200.537 182.812 1.00 49.89 ? 312 GLY A O   1 
ATOM   4129 N N   . GLU C 3 313 ? 216.150 200.891 183.273 1.00 51.54 ? 313 GLU A N   1 
ATOM   4130 C CA  . GLU C 3 313 ? 216.033 199.648 184.016 1.00 51.54 ? 313 GLU A CA  1 
ATOM   4131 C C   . GLU C 3 313 ? 216.133 198.461 183.061 1.00 51.54 ? 313 GLU A C   1 
ATOM   4132 O O   . GLU C 3 313 ? 215.524 198.476 181.986 1.00 51.54 ? 313 GLU A O   1 
ATOM   4133 C CB  . GLU C 3 313 ? 214.710 199.602 184.775 1.00 51.54 ? 313 GLU A CB  1 
ATOM   4134 C CG  . GLU C 3 313 ? 214.564 198.415 185.709 1.00 51.54 ? 313 GLU A CG  1 
ATOM   4135 C CD  . GLU C 3 313 ? 213.385 198.555 186.650 1.00 51.54 ? 313 GLU A CD  1 
ATOM   4136 O OE1 . GLU C 3 313 ? 213.396 199.484 187.486 1.00 51.54 ? 313 GLU A OE1 1 
ATOM   4137 O OE2 . GLU C 3 313 ? 212.446 197.737 186.555 1.00 51.54 ? 313 GLU A OE2 1 
ATOM   4138 N N   . PRO C 3 314 ? 216.895 197.428 183.414 1.00 49.25 ? 314 PRO A N   1 
ATOM   4139 C CA  . PRO C 3 314 ? 217.059 196.289 182.506 1.00 49.25 ? 314 PRO A CA  1 
ATOM   4140 C C   . PRO C 3 314 ? 215.751 195.550 182.269 1.00 49.25 ? 314 PRO A C   1 
ATOM   4141 O O   . PRO C 3 314 ? 214.857 195.534 183.117 1.00 49.25 ? 314 PRO A O   1 
ATOM   4142 C CB  . PRO C 3 314 ? 218.074 195.399 183.231 1.00 49.25 ? 314 PRO A CB  1 
ATOM   4143 C CG  . PRO C 3 314 ? 218.763 196.299 184.184 1.00 49.25 ? 314 PRO A CG  1 
ATOM   4144 C CD  . PRO C 3 314 ? 217.748 197.309 184.605 1.00 49.25 ? 314 PRO A CD  1 
ATOM   4145 N N   . ILE C 3 315 ? 215.652 194.934 181.095 1.00 46.38 ? 315 ILE A N   1 
ATOM   4146 C CA  . ILE C 3 315 ? 214.480 194.168 180.685 1.00 46.38 ? 315 ILE A CA  1 
ATOM   4147 C C   . ILE C 3 315 ? 214.900 192.714 180.547 1.00 46.38 ? 315 ILE A C   1 
ATOM   4148 O O   . ILE C 3 315 ? 215.785 192.392 179.746 1.00 46.38 ? 315 ILE A O   1 
ATOM   4149 C CB  . ILE C 3 315 ? 213.894 194.697 179.372 1.00 46.38 ? 315 ILE A CB  1 
ATOM   4150 C CG1 . ILE C 3 315 ? 213.528 196.171 179.516 1.00 46.38 ? 315 ILE A CG1 1 
ATOM   4151 C CG2 . ILE C 3 315 ? 212.683 193.885 178.965 1.00 46.38 ? 315 ILE A CG2 1 
ATOM   4152 C CD1 . ILE C 3 315 ? 212.944 196.775 178.266 1.00 46.38 ? 315 ILE A CD1 1 
ATOM   4153 N N   . SER C 3 316 ? 214.261 191.836 181.313 1.00 45.79 ? 316 SER A N   1 
ATOM   4154 C CA  . SER C 3 316 ? 214.637 190.432 181.396 1.00 45.79 ? 316 SER A CA  1 
ATOM   4155 C C   . SER C 3 316 ? 213.627 189.578 180.644 1.00 45.79 ? 316 SER A C   1 
ATOM   4156 O O   . SER C 3 316 ? 212.417 189.719 180.846 1.00 45.79 ? 316 SER A O   1 
ATOM   4157 C CB  . SER C 3 316 ? 214.722 189.982 182.852 1.00 45.79 ? 316 SER A CB  1 
ATOM   4158 O OG  . SER C 3 316 ? 213.530 190.304 183.542 1.00 45.79 ? 316 SER A OG  1 
ATOM   4159 N N   . VAL C 3 317 ? 214.126 188.688 179.789 1.00 43.78 ? 317 VAL A N   1 
ATOM   4160 C CA  . VAL C 3 317 ? 213.289 187.850 178.940 1.00 43.78 ? 317 VAL A CA  1 
ATOM   4161 C C   . VAL C 3 317 ? 213.570 186.395 179.278 1.00 43.78 ? 317 VAL A C   1 
ATOM   4162 O O   . VAL C 3 317 ? 214.708 185.930 179.139 1.00 43.78 ? 317 VAL A O   1 
ATOM   4163 C CB  . VAL C 3 317 ? 213.548 188.112 177.449 1.00 43.78 ? 317 VAL A CB  1 
ATOM   4164 C CG1 . VAL C 3 317 ? 212.426 187.538 176.609 1.00 43.78 ? 317 VAL A CG1 1 
ATOM   4165 C CG2 . VAL C 3 317 ? 213.723 189.598 177.185 1.00 43.78 ? 317 VAL A CG2 1 
ATOM   4166 N N   . ASN C 3 318 ? 212.542 185.679 179.712 1.00 43.08 ? 318 ASN A N   1 
ATOM   4167 C CA  . ASN C 3 318 ? 212.623 184.235 179.855 1.00 43.08 ? 318 ASN A CA  1 
ATOM   4168 C C   . ASN C 3 318 ? 212.478 183.570 178.494 1.00 43.08 ? 318 ASN A C   1 
ATOM   4169 O O   . ASN C 3 318 ? 211.790 184.077 177.606 1.00 43.08 ? 318 ASN A O   1 
ATOM   4170 C CB  . ASN C 3 318 ? 211.531 183.720 180.793 1.00 43.08 ? 318 ASN A CB  1 
ATOM   4171 C CG  . ASN C 3 318 ? 211.533 184.416 182.137 1.00 43.08 ? 318 ASN A CG  1 
ATOM   4172 O OD1 . ASN C 3 318 ? 211.987 183.859 183.134 1.00 43.08 ? 318 ASN A OD1 1 
ATOM   4173 N ND2 . ASN C 3 318 ? 211.017 185.637 182.173 1.00 43.08 ? 318 ASN A ND2 1 
ATOM   4174 N N   . VAL C 3 319 ? 213.138 182.431 178.330 1.00 41.59 ? 319 VAL A N   1 
ATOM   4175 C CA  . VAL C 3 319 ? 213.095 181.672 177.086 1.00 41.59 ? 319 VAL A CA  1 
ATOM   4176 C C   . VAL C 3 319 ? 213.087 180.190 177.426 1.00 41.59 ? 319 VAL A C   1 
ATOM   4177 O O   . VAL C 3 319 ? 213.829 179.742 178.304 1.00 41.59 ? 319 VAL A O   1 
ATOM   4178 C CB  . VAL C 3 319 ? 214.289 182.010 176.169 1.00 41.59 ? 319 VAL A CB  1 
ATOM   4179 C CG1 . VAL C 3 319 ? 214.428 180.977 175.076 1.00 41.59 ? 319 VAL A CG1 1 
ATOM   4180 C CG2 . VAL C 3 319 ? 214.131 183.378 175.565 1.00 41.59 ? 319 VAL A CG2 1 
ATOM   4181 N N   . HIS C 3 320 ? 212.247 179.428 176.731 1.00 46.61 ? 320 HIS A N   1 
ATOM   4182 C CA  . HIS C 3 320 ? 212.159 177.988 176.926 1.00 46.61 ? 320 HIS A CA  1 
ATOM   4183 C C   . HIS C 3 320 ? 212.059 177.311 175.570 1.00 46.61 ? 320 HIS A C   1 
ATOM   4184 O O   . HIS C 3 320 ? 211.236 177.706 174.740 1.00 46.61 ? 320 HIS A O   1 
ATOM   4185 C CB  . HIS C 3 320 ? 210.949 177.626 177.787 1.00 46.61 ? 320 HIS A CB  1 
ATOM   4186 C CG  . HIS C 3 320 ? 210.926 176.198 178.227 1.00 46.61 ? 320 HIS A CG  1 
ATOM   4187 N ND1 . HIS C 3 320 ? 209.772 175.564 178.628 1.00 46.61 ? 320 HIS A ND1 1 
ATOM   4188 C CD2 . HIS C 3 320 ? 211.915 175.281 178.331 1.00 46.61 ? 320 HIS A CD2 1 
ATOM   4189 C CE1 . HIS C 3 320 ? 210.050 174.317 178.961 1.00 46.61 ? 320 HIS A CE1 1 
ATOM   4190 N NE2 . HIS C 3 320 ? 211.344 174.120 178.790 1.00 46.61 ? 320 HIS A NE2 1 
ATOM   4191 N N   . VAL C 3 321 ? 212.889 176.297 175.347 1.00 48.15 ? 321 VAL A N   1 
ATOM   4192 C CA  . VAL C 3 321 ? 212.912 175.565 174.088 1.00 48.15 ? 321 VAL A CA  1 
ATOM   4193 C C   . VAL C 3 321 ? 212.836 174.079 174.396 1.00 48.15 ? 321 VAL A C   1 
ATOM   4194 O O   . VAL C 3 321 ? 213.711 173.541 175.083 1.00 48.15 ? 321 VAL A O   1 
ATOM   4195 C CB  . VAL C 3 321 ? 214.173 175.874 173.265 1.00 48.15 ? 321 VAL A CB  1 
ATOM   4196 C CG1 . VAL C 3 321 ? 214.271 174.936 172.085 1.00 48.15 ? 321 VAL A CG1 1 
ATOM   4197 C CG2 . VAL C 3 321 ? 214.166 177.316 172.800 1.00 48.15 ? 321 VAL A CG2 1 
ATOM   4198 N N   . THR C 3 322 ? 211.800 173.416 173.891 1.00 49.79 ? 322 THR A N   1 
ATOM   4199 C CA  . THR C 3 322 ? 211.651 171.967 173.997 1.00 49.79 ? 322 THR A CA  1 
ATOM   4200 C C   . THR C 3 322 ? 211.619 171.418 172.577 1.00 49.79 ? 322 THR A C   1 
ATOM   4201 O O   . THR C 3 322 ? 210.550 171.252 171.989 1.00 49.79 ? 322 THR A O   1 
ATOM   4202 C CB  . THR C 3 322 ? 210.396 171.579 174.764 1.00 49.79 ? 322 THR A CB  1 
ATOM   4203 O OG1 . THR C 3 322 ? 209.249 171.785 173.933 1.00 49.79 ? 322 THR A OG1 1 
ATOM   4204 C CG2 . THR C 3 322 ? 210.257 172.418 176.022 1.00 49.79 ? 322 THR A CG2 1 
ATOM   4205 N N   . ASN C 3 323 ? 212.794 171.139 172.025 1.00 56.55 ? 323 ASN A N   1 
ATOM   4206 C CA  . ASN C 3 323 ? 212.899 170.635 170.665 1.00 56.55 ? 323 ASN A CA  1 
ATOM   4207 C C   . ASN C 3 323 ? 212.550 169.157 170.661 1.00 56.55 ? 323 ASN A C   1 
ATOM   4208 O O   . ASN C 3 323 ? 212.898 168.419 171.587 1.00 56.55 ? 323 ASN A O   1 
ATOM   4209 C CB  . ASN C 3 323 ? 214.313 170.858 170.116 1.00 56.55 ? 323 ASN A CB  1 
ATOM   4210 C CG  . ASN C 3 323 ? 214.596 170.098 168.814 1.00 56.55 ? 323 ASN A CG  1 
ATOM   4211 O OD1 . ASN C 3 323 ? 213.791 169.307 168.324 1.00 56.55 ? 323 ASN A OD1 1 
ATOM   4212 N ND2 . ASN C 3 323 ? 215.769 170.354 168.249 1.00 56.55 ? 323 ASN A ND2 1 
ATOM   4213 N N   . ASN C 3 324 ? 211.862 168.729 169.602 1.00 58.23 ? 324 ASN A N   1 
ATOM   4214 C CA  . ASN C 3 324 ? 211.567 167.316 169.404 1.00 58.23 ? 324 ASN A CA  1 
ATOM   4215 C C   . ASN C 3 324 ? 211.738 166.910 167.945 1.00 58.23 ? 324 ASN A C   1 
ATOM   4216 O O   . ASN C 3 324 ? 211.128 165.927 167.509 1.00 58.23 ? 324 ASN A O   1 
ATOM   4217 C CB  . ASN C 3 324 ? 210.156 166.971 169.883 1.00 58.23 ? 324 ASN A CB  1 
ATOM   4218 C CG  . ASN C 3 324 ? 210.085 166.758 171.377 1.00 58.23 ? 324 ASN A CG  1 
ATOM   4219 O OD1 . ASN C 3 324 ? 210.517 165.727 171.886 1.00 58.23 ? 324 ASN A OD1 1 
ATOM   4220 N ND2 . ASN C 3 324 ? 209.529 167.728 172.089 1.00 58.23 ? 324 ASN A ND2 1 
ATOM   4221 N N   . THR C 3 325 ? 212.540 167.641 167.184 1.00 61.57 ? 325 THR A N   1 
ATOM   4222 C CA  . THR C 3 325 ? 212.801 167.325 165.794 1.00 61.57 ? 325 THR A CA  1 
ATOM   4223 C C   . THR C 3 325 ? 214.228 166.808 165.643 1.00 61.57 ? 325 THR A C   1 
ATOM   4224 O O   . THR C 3 325 ? 214.954 166.620 166.623 1.00 61.57 ? 325 THR A O   1 
ATOM   4225 C CB  . THR C 3 325 ? 212.561 168.554 164.918 1.00 61.57 ? 325 THR A CB  1 
ATOM   4226 O OG1 . THR C 3 325 ? 213.740 169.369 164.905 1.00 61.57 ? 325 THR A OG1 1 
ATOM   4227 C CG2 . THR C 3 325 ? 211.393 169.371 165.453 1.00 61.57 ? 325 THR A CG2 1 
ATOM   4228 N N   . ASN C 3 326 ? 214.639 166.575 164.402 1.00 62.82 ? 326 ASN A N   1 
ATOM   4229 C CA  . ASN C 3 326 ? 215.972 166.079 164.102 1.00 62.82 ? 326 ASN A CA  1 
ATOM   4230 C C   . ASN C 3 326 ? 216.959 167.183 163.751 1.00 62.82 ? 326 ASN A C   1 
ATOM   4231 O O   . ASN C 3 326 ? 218.104 166.879 163.404 1.00 62.82 ? 326 ASN A O   1 
ATOM   4232 C CB  . ASN C 3 326 ? 215.908 165.068 162.956 1.00 62.82 ? 326 ASN A CB  1 
ATOM   4233 C CG  . ASN C 3 326 ? 214.760 164.099 163.104 1.00 62.82 ? 326 ASN A CG  1 
ATOM   4234 O OD1 . ASN C 3 326 ? 213.595 164.498 163.123 1.00 62.82 ? 326 ASN A OD1 1 
ATOM   4235 N ND2 . ASN C 3 326 ? 215.079 162.814 163.206 1.00 62.82 ? 326 ASN A ND2 1 
ATOM   4236 N N   . LYS C 3 327 ? 216.551 168.445 163.819 1.00 62.36 ? 327 LYS A N   1 
ATOM   4237 C CA  . LYS C 3 327 ? 217.442 169.564 163.551 1.00 62.36 ? 327 LYS A CA  1 
ATOM   4238 C C   . LYS C 3 327 ? 217.960 170.153 164.859 1.00 62.36 ? 327 LYS A C   1 
ATOM   4239 O O   . LYS C 3 327 ? 217.491 169.823 165.950 1.00 62.36 ? 327 LYS A O   1 
ATOM   4240 C CB  . LYS C 3 327 ? 216.729 170.634 162.722 1.00 62.36 ? 327 LYS A CB  1 
ATOM   4241 C CG  . LYS C 3 327 ? 216.597 170.292 161.251 1.00 62.36 ? 327 LYS A CG  1 
ATOM   4242 C CD  . LYS C 3 327 ? 215.730 171.312 160.533 1.00 62.36 ? 327 LYS A CD  1 
ATOM   4243 C CE  . LYS C 3 327 ? 215.661 171.035 159.046 1.00 62.36 ? 327 LYS A CE  1 
ATOM   4244 N NZ  . LYS C 3 327 ? 215.021 169.722 158.764 1.00 62.36 ? 327 LYS A NZ  1 
ATOM   4245 N N   . THR C 3 328 ? 218.947 171.039 164.739 1.00 56.58 ? 328 THR A N   1 
ATOM   4246 C CA  . THR C 3 328 ? 219.611 171.632 165.891 1.00 56.58 ? 328 THR A CA  1 
ATOM   4247 C C   . THR C 3 328 ? 219.522 173.149 165.826 1.00 56.58 ? 328 THR A C   1 
ATOM   4248 O O   . THR C 3 328 ? 219.646 173.739 164.751 1.00 56.58 ? 328 THR A O   1 
ATOM   4249 C CB  . THR C 3 328 ? 221.079 171.212 165.965 1.00 56.58 ? 328 THR A CB  1 
ATOM   4250 O OG1 . THR C 3 328 ? 221.810 171.841 164.905 1.00 56.58 ? 328 THR A OG1 1 
ATOM   4251 C CG2 . THR C 3 328 ? 221.212 169.703 165.839 1.00 56.58 ? 328 THR A CG2 1 
ATOM   4252 N N   . VAL C 3 329 ? 219.315 173.776 166.980 1.00 52.12 ? 329 VAL A N   1 
ATOM   4253 C CA  . VAL C 3 329 ? 219.222 175.230 167.053 1.00 52.12 ? 329 VAL A CA  1 
ATOM   4254 C C   . VAL C 3 329 ? 220.616 175.812 167.241 1.00 52.12 ? 329 VAL A C   1 
ATOM   4255 O O   . VAL C 3 329 ? 221.361 175.399 168.137 1.00 52.12 ? 329 VAL A O   1 
ATOM   4256 C CB  . VAL C 3 329 ? 218.278 175.657 168.185 1.00 52.12 ? 329 VAL A CB  1 
ATOM   4257 C CG1 . VAL C 3 329 ? 218.466 177.127 168.507 1.00 52.12 ? 329 VAL A CG1 1 
ATOM   4258 C CG2 . VAL C 3 329 ? 216.843 175.395 167.785 1.00 52.12 ? 329 VAL A CG2 1 
ATOM   4259 N N   . LYS C 3 330 ? 220.970 176.783 166.397 1.00 51.26 ? 330 LYS A N   1 
ATOM   4260 C CA  . LYS C 3 330 ? 222.324 177.321 166.349 1.00 51.26 ? 330 LYS A CA  1 
ATOM   4261 C C   . LYS C 3 330 ? 222.507 178.486 167.315 1.00 51.26 ? 330 LYS A C   1 
ATOM   4262 O O   . LYS C 3 330 ? 223.478 178.503 168.077 1.00 51.26 ? 330 LYS A O   1 
ATOM   4263 C CB  . LYS C 3 330 ? 222.649 177.743 164.908 1.00 51.26 ? 330 LYS A CB  1 
ATOM   4264 C CG  . LYS C 3 330 ? 223.869 178.661 164.621 1.00 51.26 ? 330 LYS A CG  1 
ATOM   4265 C CD  . LYS C 3 330 ? 225.114 178.522 165.516 1.00 51.26 ? 330 LYS A CD  1 
ATOM   4266 C CE  . LYS C 3 330 ? 225.612 177.085 165.642 1.00 51.26 ? 330 LYS A CE  1 
ATOM   4267 N NZ  . LYS C 3 330 ? 226.906 177.019 166.372 1.00 51.26 ? 330 LYS A NZ  1 
ATOM   4268 N N   . LYS C 3 331 ? 221.594 179.454 167.323 1.00 49.09 ? 331 LYS A N   1 
ATOM   4269 C CA  . LYS C 3 331 ? 221.720 180.584 168.234 1.00 49.09 ? 331 LYS A CA  1 
ATOM   4270 C C   . LYS C 3 331 ? 220.340 181.151 168.539 1.00 49.09 ? 331 LYS A C   1 
ATOM   4271 O O   . LYS C 3 331 ? 219.353 180.833 167.875 1.00 49.09 ? 331 LYS A O   1 
ATOM   4272 C CB  . LYS C 3 331 ? 222.646 181.660 167.659 1.00 49.09 ? 331 LYS A CB  1 
ATOM   4273 C CG  . LYS C 3 331 ? 222.511 181.873 166.164 1.00 49.09 ? 331 LYS A CG  1 
ATOM   4274 C CD  . LYS C 3 331 ? 223.590 182.811 165.648 1.00 49.09 ? 331 LYS A CD  1 
ATOM   4275 C CE  . LYS C 3 331 ? 223.559 182.912 164.134 1.00 49.09 ? 331 LYS A CE  1 
ATOM   4276 N NZ  . LYS C 3 331 ? 224.214 181.748 163.481 1.00 49.09 ? 331 LYS A NZ  1 
ATOM   4277 N N   . ILE C 3 332 ? 220.287 181.993 169.568 1.00 45.51 ? 332 ILE A N   1 
ATOM   4278 C CA  . ILE C 3 332 ? 219.067 182.666 169.995 1.00 45.51 ? 332 ILE A CA  1 
ATOM   4279 C C   . ILE C 3 332 ? 219.310 184.166 169.947 1.00 45.51 ? 332 ILE A C   1 
ATOM   4280 O O   . ILE C 3 332 ? 220.345 184.646 170.420 1.00 45.51 ? 332 ILE A O   1 
ATOM   4281 C CB  . ILE C 3 332 ? 218.635 182.233 171.407 1.00 45.51 ? 332 ILE A CB  1 
ATOM   4282 C CG1 . ILE C 3 332 ? 218.419 180.726 171.462 1.00 45.51 ? 332 ILE A CG1 1 
ATOM   4283 C CG2 . ILE C 3 332 ? 217.372 182.952 171.815 1.00 45.51 ? 332 ILE A CG2 1 
ATOM   4284 C CD1 . ILE C 3 332 ? 217.570 180.285 172.628 1.00 45.51 ? 332 ILE A CD1 1 
ATOM   4285 N N   . LYS C 3 333 ? 218.364 184.899 169.367 1.00 44.67 ? 333 LYS A N   1 
ATOM   4286 C CA  . LYS C 3 333 ? 218.448 186.346 169.230 1.00 44.67 ? 333 LYS A CA  1 
ATOM   4287 C C   . LYS C 3 333 ? 217.335 187.000 170.034 1.00 44.67 ? 333 LYS A C   1 
ATOM   4288 O O   . LYS C 3 333 ? 216.162 186.657 169.867 1.00 44.67 ? 333 LYS A O   1 
ATOM   4289 C CB  . LYS C 3 333 ? 218.354 186.758 167.763 1.00 44.67 ? 333 LYS A CB  1 
ATOM   4290 C CG  . LYS C 3 333 ? 219.624 186.520 166.975 1.00 44.67 ? 333 LYS A CG  1 
ATOM   4291 C CD  . LYS C 3 333 ? 219.802 187.565 165.893 1.00 44.67 ? 333 LYS A CD  1 
ATOM   4292 C CE  . LYS C 3 333 ? 219.952 186.920 164.528 1.00 44.67 ? 333 LYS A CE  1 
ATOM   4293 N NZ  . LYS C 3 333 ? 221.327 186.390 164.319 1.00 44.67 ? 333 LYS A NZ  1 
ATOM   4294 N N   . ILE C 3 334 ? 217.706 187.939 170.899 1.00 44.21 ? 334 ILE A N   1 
ATOM   4295 C CA  . ILE C 3 334 ? 216.766 188.686 171.724 1.00 44.21 ? 334 ILE A CA  1 
ATOM   4296 C C   . ILE C 3 334 ? 216.881 190.155 171.352 1.00 44.21 ? 334 ILE A C   1 
ATOM   4297 O O   . ILE C 3 334 ? 217.986 190.706 171.321 1.00 44.21 ? 334 ILE A O   1 
ATOM   4298 C CB  . ILE C 3 334 ? 217.037 188.483 173.224 1.00 44.21 ? 334 ILE A CB  1 
ATOM   4299 C CG1 . ILE C 3 334 ? 217.547 187.072 173.485 1.00 44.21 ? 334 ILE A CG1 1 
ATOM   4300 C CG2 . ILE C 3 334 ? 215.782 188.754 174.031 1.00 44.21 ? 334 ILE A CG2 1 
ATOM   4301 C CD1 . ILE C 3 334 ? 216.481 186.023 173.402 1.00 44.21 ? 334 ILE A CD1 1 
ATOM   4302 N N   . SER C 3 335 ? 215.745 190.789 171.071 1.00 43.10 ? 335 SER A N   1 
ATOM   4303 C CA  . SER C 3 335 ? 215.747 192.153 170.571 1.00 43.10 ? 335 SER A CA  1 
ATOM   4304 C C   . SER C 3 335 ? 214.572 192.928 171.144 1.00 43.10 ? 335 SER A C   1 
ATOM   4305 O O   . SER C 3 335 ? 213.547 192.355 171.516 1.00 43.10 ? 335 SER A O   1 
ATOM   4306 C CB  . SER C 3 335 ? 215.695 192.184 169.041 1.00 43.10 ? 335 SER A CB  1 
ATOM   4307 O OG  . SER C 3 335 ? 214.530 191.543 168.559 1.00 43.10 ? 335 SER A OG  1 
ATOM   4308 N N   . VAL C 3 336 ? 214.739 194.243 171.208 1.00 43.98 ? 336 VAL A N   1 
ATOM   4309 C CA  . VAL C 3 336 ? 213.698 195.164 171.635 1.00 43.98 ? 336 VAL A CA  1 
ATOM   4310 C C   . VAL C 3 336 ? 213.455 196.136 170.491 1.00 43.98 ? 336 VAL A C   1 
ATOM   4311 O O   . VAL C 3 336 ? 214.389 196.800 170.026 1.00 43.98 ? 336 VAL A O   1 
ATOM   4312 C CB  . VAL C 3 336 ? 214.091 195.905 172.919 1.00 43.98 ? 336 VAL A CB  1 
ATOM   4313 C CG1 . VAL C 3 336 ? 213.035 196.929 173.276 1.00 43.98 ? 336 VAL A CG1 1 
ATOM   4314 C CG2 . VAL C 3 336 ? 214.272 194.919 174.046 1.00 43.98 ? 336 VAL A CG2 1 
ATOM   4315 N N   . ARG C 3 337 ? 212.210 196.221 170.041 1.00 45.75 ? 337 ARG A N   1 
ATOM   4316 C CA  . ARG C 3 337 ? 211.855 196.975 168.852 1.00 45.75 ? 337 ARG A CA  1 
ATOM   4317 C C   . ARG C 3 337 ? 210.887 198.091 169.207 1.00 45.75 ? 337 ARG A C   1 
ATOM   4318 O O   . ARG C 3 337 ? 210.076 197.964 170.130 1.00 45.75 ? 337 ARG A O   1 
ATOM   4319 C CB  . ARG C 3 337 ? 211.236 196.066 167.796 1.00 45.75 ? 337 ARG A CB  1 
ATOM   4320 C CG  . ARG C 3 337 ? 212.188 195.026 167.270 1.00 45.75 ? 337 ARG A CG  1 
ATOM   4321 C CD  . ARG C 3 337 ? 211.500 193.698 167.076 1.00 45.75 ? 337 ARG A CD  1 
ATOM   4322 N NE  . ARG C 3 337 ? 210.969 193.540 165.729 1.00 45.75 ? 337 ARG A NE  1 
ATOM   4323 C CZ  . ARG C 3 337 ? 211.711 193.327 164.652 1.00 45.75 ? 337 ARG A CZ  1 
ATOM   4324 N NH1 . ARG C 3 337 ? 213.029 193.237 164.726 1.00 45.75 ? 337 ARG A NH1 1 
ATOM   4325 N NH2 . ARG C 3 337 ? 211.116 193.194 163.471 1.00 45.75 ? 337 ARG A NH2 1 
ATOM   4326 N N   . GLN C 3 338 ? 210.982 199.187 168.467 1.00 48.51 ? 338 GLN A N   1 
ATOM   4327 C CA  . GLN C 3 338 ? 210.125 200.346 168.652 1.00 48.51 ? 338 GLN A CA  1 
ATOM   4328 C C   . GLN C 3 338 ? 209.155 200.448 167.488 1.00 48.51 ? 338 GLN A C   1 
ATOM   4329 O O   . GLN C 3 338 ? 209.573 200.448 166.328 1.00 48.51 ? 338 GLN A O   1 
ATOM   4330 C CB  . GLN C 3 338 ? 210.954 201.621 168.752 1.00 48.51 ? 338 GLN A CB  1 
ATOM   4331 C CG  . GLN C 3 338 ? 210.152 202.848 169.091 1.00 48.51 ? 338 GLN A CG  1 
ATOM   4332 C CD  . GLN C 3 338 ? 211.004 204.089 169.125 1.00 48.51 ? 338 GLN A CD  1 
ATOM   4333 O OE1 . GLN C 3 338 ? 211.250 204.714 168.097 1.00 48.51 ? 338 GLN A OE1 1 
ATOM   4334 N NE2 . GLN C 3 338 ? 211.466 204.455 170.313 1.00 48.51 ? 338 GLN A NE2 1 
ATOM   4335 N N   . TYR C 3 339 ? 207.868 200.543 167.799 1.00 49.66 ? 339 TYR A N   1 
ATOM   4336 C CA  . TYR C 3 339 ? 206.818 200.694 166.804 1.00 49.66 ? 339 TYR A CA  1 
ATOM   4337 C C   . TYR C 3 339 ? 206.224 202.088 166.930 1.00 49.66 ? 339 TYR A C   1 
ATOM   4338 O O   . TYR C 3 339 ? 205.636 202.425 167.962 1.00 49.66 ? 339 TYR A O   1 
ATOM   4339 C CB  . TYR C 3 339 ? 205.744 199.624 166.986 1.00 49.66 ? 339 TYR A CB  1 
ATOM   4340 C CG  . TYR C 3 339 ? 206.225 198.241 166.638 1.00 49.66 ? 339 TYR A CG  1 
ATOM   4341 C CD1 . TYR C 3 339 ? 207.024 197.524 167.511 1.00 49.66 ? 339 TYR A CD1 1 
ATOM   4342 C CD2 . TYR C 3 339 ? 205.894 197.660 165.431 1.00 49.66 ? 339 TYR A CD2 1 
ATOM   4343 C CE1 . TYR C 3 339 ? 207.470 196.263 167.191 1.00 49.66 ? 339 TYR A CE1 1 
ATOM   4344 C CE2 . TYR C 3 339 ? 206.334 196.401 165.104 1.00 49.66 ? 339 TYR A CE2 1 
ATOM   4345 C CZ  . TYR C 3 339 ? 207.124 195.707 165.985 1.00 49.66 ? 339 TYR A CZ  1 
ATOM   4346 O OH  . TYR C 3 339 ? 207.566 194.446 165.665 1.00 49.66 ? 339 TYR A OH  1 
ATOM   4347 N N   . ALA C 3 340 ? 206.375 202.893 165.881 1.00 58.59 ? 340 ALA A N   1 
ATOM   4348 C CA  . ALA C 3 340 ? 205.980 204.300 165.894 1.00 58.59 ? 340 ALA A CA  1 
ATOM   4349 C C   . ALA C 3 340 ? 205.159 204.594 164.645 1.00 58.59 ? 340 ALA A C   1 
ATOM   4350 O O   . ALA C 3 340 ? 205.718 204.849 163.576 1.00 58.59 ? 340 ALA A O   1 
ATOM   4351 C CB  . ALA C 3 340 ? 207.202 205.204 165.973 1.00 58.59 ? 340 ALA A CB  1 
ATOM   4352 N N   . ASP C 3 341 ? 203.839 204.561 164.779 1.00 66.18 ? 341 ASP A N   1 
ATOM   4353 C CA  . ASP C 3 341 ? 202.951 204.874 163.674 1.00 66.18 ? 341 ASP A CA  1 
ATOM   4354 C C   . ASP C 3 341 ? 202.494 206.322 163.786 1.00 66.18 ? 341 ASP A C   1 
ATOM   4355 O O   . ASP C 3 341 ? 202.186 206.803 164.880 1.00 66.18 ? 341 ASP A O   1 
ATOM   4356 C CB  . ASP C 3 341 ? 201.760 203.915 163.641 1.00 66.18 ? 341 ASP A CB  1 
ATOM   4357 C CG  . ASP C 3 341 ? 200.695 204.266 164.650 1.00 66.18 ? 341 ASP A CG  1 
ATOM   4358 O OD1 . ASP C 3 341 ? 199.499 204.221 164.292 1.00 66.18 ? 341 ASP A OD1 1 
ATOM   4359 O OD2 . ASP C 3 341 ? 201.047 204.556 165.809 1.00 66.18 ? 341 ASP A OD2 1 
ATOM   4360 N N   . ILE C 3 342 ? 202.489 207.020 162.658 1.00 68.98 ? 342 ILE A N   1 
ATOM   4361 C CA  . ILE C 3 342 ? 202.252 208.461 162.623 1.00 68.98 ? 342 ILE A CA  1 
ATOM   4362 C C   . ILE C 3 342 ? 200.776 208.652 162.295 1.00 68.98 ? 342 ILE A C   1 
ATOM   4363 O O   . ILE C 3 342 ? 200.342 208.493 161.155 1.00 68.98 ? 342 ILE A O   1 
ATOM   4364 C CB  . ILE C 3 342 ? 203.164 209.156 161.621 1.00 68.98 ? 342 ILE A CB  1 
ATOM   4365 C CG1 . ILE C 3 342 ? 204.612 208.743 161.869 1.00 68.98 ? 342 ILE A CG1 1 
ATOM   4366 C CG2 . ILE C 3 342 ? 203.024 210.658 161.734 1.00 68.98 ? 342 ILE A CG2 1 
ATOM   4367 C CD1 . ILE C 3 342 ? 205.075 208.967 163.287 1.00 68.98 ? 342 ILE A CD1 1 
ATOM   4368 N N   . CYS C 3 343 ? 199.994 209.015 163.311 1.00 77.01 ? 343 CYS A N   1 
ATOM   4369 C CA  . CYS C 3 343 ? 198.549 209.131 163.158 1.00 77.01 ? 343 CYS A CA  1 
ATOM   4370 C C   . CYS C 3 343 ? 198.155 210.447 162.500 1.00 77.01 ? 343 CYS A C   1 
ATOM   4371 O O   . CYS C 3 343 ? 197.381 211.226 163.065 1.00 77.01 ? 343 CYS A O   1 
ATOM   4372 C CB  . CYS C 3 343 ? 197.854 208.990 164.513 1.00 77.01 ? 343 CYS A CB  1 
ATOM   4373 S SG  . CYS C 3 343 ? 198.199 207.434 165.361 1.00 77.01 ? 343 CYS A SG  1 
ATOM   4374 N N   . LEU C 3 344 ? 198.689 210.700 161.312 1.00 78.94 ? 344 LEU A N   1 
ATOM   4375 C CA  . LEU C 3 344 ? 198.206 211.764 160.452 1.00 78.94 ? 344 LEU A CA  1 
ATOM   4376 C C   . LEU C 3 344 ? 197.298 211.148 159.388 1.00 78.94 ? 344 LEU A C   1 
ATOM   4377 O O   . LEU C 3 344 ? 196.982 209.956 159.423 1.00 78.94 ? 344 LEU A O   1 
ATOM   4378 C CB  . LEU C 3 344 ? 199.381 212.520 159.835 1.00 78.94 ? 344 LEU A CB  1 
ATOM   4379 C CG  . LEU C 3 344 ? 199.160 213.948 159.339 1.00 78.94 ? 344 LEU A CG  1 
ATOM   4380 C CD1 . LEU C 3 344 ? 198.604 214.824 160.449 1.00 78.94 ? 344 LEU A CD1 1 
ATOM   4381 C CD2 . LEU C 3 344 ? 200.452 214.523 158.788 1.00 78.94 ? 344 LEU A CD2 1 
ATOM   4382 N N   . PHE C 3 345 ? 196.862 211.963 158.426 1.00 83.76 ? 345 PHE A N   1 
ATOM   4383 C CA  . PHE C 3 345 ? 196.083 211.427 157.318 1.00 83.76 ? 345 PHE A CA  1 
ATOM   4384 C C   . PHE C 3 345 ? 196.906 210.499 156.435 1.00 83.76 ? 345 PHE A C   1 
ATOM   4385 O O   . PHE C 3 345 ? 196.331 209.688 155.702 1.00 83.76 ? 345 PHE A O   1 
ATOM   4386 C CB  . PHE C 3 345 ? 195.498 212.568 156.482 1.00 83.76 ? 345 PHE A CB  1 
ATOM   4387 C CG  . PHE C 3 345 ? 196.533 213.465 155.866 1.00 83.76 ? 345 PHE A CG  1 
ATOM   4388 C CD1 . PHE C 3 345 ? 197.010 214.566 156.555 1.00 83.76 ? 345 PHE A CD1 1 
ATOM   4389 C CD2 . PHE C 3 345 ? 197.025 213.211 154.597 1.00 83.76 ? 345 PHE A CD2 1 
ATOM   4390 C CE1 . PHE C 3 345 ? 197.961 215.394 155.993 1.00 83.76 ? 345 PHE A CE1 1 
ATOM   4391 C CE2 . PHE C 3 345 ? 197.976 214.035 154.030 1.00 83.76 ? 345 PHE A CE2 1 
ATOM   4392 C CZ  . PHE C 3 345 ? 198.444 215.129 154.729 1.00 83.76 ? 345 PHE A CZ  1 
ATOM   4393 N N   . ASN C 3 346 ? 198.235 210.599 156.491 1.00 83.06 ? 346 ASN A N   1 
ATOM   4394 C CA  . ASN C 3 346 ? 199.106 209.746 155.692 1.00 83.06 ? 346 ASN A CA  1 
ATOM   4395 C C   . ASN C 3 346 ? 199.347 208.380 156.324 1.00 83.06 ? 346 ASN A C   1 
ATOM   4396 O O   . ASN C 3 346 ? 199.872 207.490 155.647 1.00 83.06 ? 346 ASN A O   1 
ATOM   4397 C CB  . ASN C 3 346 ? 200.435 210.464 155.444 1.00 83.06 ? 346 ASN A CB  1 
ATOM   4398 C CG  . ASN C 3 346 ? 201.058 211.000 156.721 1.00 83.06 ? 346 ASN A CG  1 
ATOM   4399 O OD1 . ASN C 3 346 ? 200.963 210.385 157.783 1.00 83.06 ? 346 ASN A OD1 1 
ATOM   4400 N ND2 . ASN C 3 346 ? 201.683 212.168 156.625 1.00 83.06 ? 346 ASN A ND2 1 
ATOM   4401 N N   . THR C 3 347 ? 198.976 208.209 157.595 1.00 80.21 ? 347 THR A N   1 
ATOM   4402 C CA  . THR C 3 347 ? 199.052 206.944 158.343 1.00 80.21 ? 347 THR A CA  1 
ATOM   4403 C C   . THR C 3 347 ? 200.298 206.129 157.992 1.00 80.21 ? 347 THR A C   1 
ATOM   4404 O O   . THR C 3 347 ? 200.245 204.920 157.756 1.00 80.21 ? 347 THR A O   1 
ATOM   4405 C CB  . THR C 3 347 ? 197.771 206.110 158.169 1.00 80.21 ? 347 THR A CB  1 
ATOM   4406 O OG1 . THR C 3 347 ? 197.880 204.900 158.931 1.00 80.21 ? 347 THR A OG1 1 
ATOM   4407 C CG2 . THR C 3 347 ? 197.486 205.761 156.705 1.00 80.21 ? 347 THR A CG2 1 
ATOM   4408 N N   . ALA C 3 348 ? 201.441 206.804 157.984 1.00 73.80 ? 348 ALA A N   1 
ATOM   4409 C CA  . ALA C 3 348 ? 202.711 206.127 157.768 1.00 73.80 ? 348 ALA A CA  1 
ATOM   4410 C C   . ALA C 3 348 ? 203.065 205.270 158.977 1.00 73.80 ? 348 ALA A C   1 
ATOM   4411 O O   . ALA C 3 348 ? 202.855 205.673 160.123 1.00 73.80 ? 348 ALA A O   1 
ATOM   4412 C CB  . ALA C 3 348 ? 203.821 207.142 157.499 1.00 73.80 ? 348 ALA A CB  1 
ATOM   4413 N N   . GLN C 3 349 ? 203.602 204.083 158.715 1.00 68.46 ? 349 GLN A N   1 
ATOM   4414 C CA  . GLN C 3 349 ? 203.995 203.149 159.760 1.00 68.46 ? 349 GLN A CA  1 
ATOM   4415 C C   . GLN C 3 349 ? 205.420 202.677 159.517 1.00 68.46 ? 349 GLN A C   1 
ATOM   4416 O O   . GLN C 3 349 ? 205.826 202.477 158.369 1.00 68.46 ? 349 GLN A O   1 
ATOM   4417 C CB  . GLN C 3 349 ? 203.050 201.947 159.807 1.00 68.46 ? 349 GLN A CB  1 
ATOM   4418 C CG  . GLN C 3 349 ? 203.098 201.164 161.107 1.00 68.46 ? 349 GLN A CG  1 
ATOM   4419 C CD  . GLN C 3 349 ? 201.744 200.610 161.500 1.00 68.46 ? 349 GLN A CD  1 
ATOM   4420 O OE1 . GLN C 3 349 ? 200.768 201.350 161.623 1.00 68.46 ? 349 GLN A OE1 1 
ATOM   4421 N NE2 . GLN C 3 349 ? 201.676 199.298 161.696 1.00 68.46 ? 349 GLN A NE2 1 
ATOM   4422 N N   . TYR C 3 350 ? 206.173 202.496 160.599 1.00 62.86 ? 350 TYR A N   1 
ATOM   4423 C CA  . TYR C 3 350 ? 207.557 202.048 160.507 1.00 62.86 ? 350 TYR A CA  1 
ATOM   4424 C C   . TYR C 3 350 ? 208.019 201.582 161.880 1.00 62.86 ? 350 TYR A C   1 
ATOM   4425 O O   . TYR C 3 350 ? 207.331 201.774 162.884 1.00 62.86 ? 350 TYR A O   1 
ATOM   4426 C CB  . TYR C 3 350 ? 208.462 203.155 159.957 1.00 62.86 ? 350 TYR A CB  1 
ATOM   4427 C CG  . TYR C 3 350 ? 208.499 204.409 160.798 1.00 62.86 ? 350 TYR A CG  1 
ATOM   4428 C CD1 . TYR C 3 350 ? 209.459 204.582 161.778 1.00 62.86 ? 350 TYR A CD1 1 
ATOM   4429 C CD2 . TYR C 3 350 ? 207.575 205.423 160.602 1.00 62.86 ? 350 TYR A CD2 1 
ATOM   4430 C CE1 . TYR C 3 350 ? 209.499 205.724 162.544 1.00 62.86 ? 350 TYR A CE1 1 
ATOM   4431 C CE2 . TYR C 3 350 ? 207.605 206.573 161.364 1.00 62.86 ? 350 TYR A CE2 1 
ATOM   4432 C CZ  . TYR C 3 350 ? 208.570 206.718 162.334 1.00 62.86 ? 350 TYR A CZ  1 
ATOM   4433 O OH  . TYR C 3 350 ? 208.605 207.862 163.098 1.00 62.86 ? 350 TYR A OH  1 
ATOM   4434 N N   . LYS C 3 351 ? 209.198 200.959 161.911 1.00 57.79 ? 351 LYS A N   1 
ATOM   4435 C CA  . LYS C 3 351 ? 209.769 200.448 163.152 1.00 57.79 ? 351 LYS A CA  1 
ATOM   4436 C C   . LYS C 3 351 ? 211.290 200.485 163.073 1.00 57.79 ? 351 LYS A C   1 
ATOM   4437 O O   . LYS C 3 351 ? 211.871 200.550 161.988 1.00 57.79 ? 351 LYS A O   1 
ATOM   4438 C CB  . LYS C 3 351 ? 209.289 199.022 163.444 1.00 57.79 ? 351 LYS A CB  1 
ATOM   4439 C CG  . LYS C 3 351 ? 210.231 197.940 162.959 1.00 57.79 ? 351 LYS A CG  1 
ATOM   4440 C CD  . LYS C 3 351 ? 209.665 196.559 163.216 1.00 57.79 ? 351 LYS A CD  1 
ATOM   4441 C CE  . LYS C 3 351 ? 208.500 196.268 162.290 1.00 57.79 ? 351 LYS A CE  1 
ATOM   4442 N NZ  . LYS C 3 351 ? 208.923 196.259 160.863 1.00 57.79 ? 351 LYS A NZ  1 
ATOM   4443 N N   . CYS C 3 352 ? 211.935 200.448 164.245 1.00 55.29 ? 352 CYS A N   1 
ATOM   4444 C CA  . CYS C 3 352 ? 213.394 200.445 164.331 1.00 55.29 ? 352 CYS A CA  1 
ATOM   4445 C C   . CYS C 3 352 ? 213.859 199.716 165.582 1.00 55.29 ? 352 CYS A C   1 
ATOM   4446 O O   . CYS C 3 352 ? 213.337 199.983 166.673 1.00 55.29 ? 352 CYS A O   1 
ATOM   4447 C CB  . CYS C 3 352 ? 213.962 201.866 164.333 1.00 55.29 ? 352 CYS A CB  1 
ATOM   4448 S SG  . CYS C 3 352 ? 214.426 202.491 162.705 1.00 55.29 ? 352 CYS A SG  1 
ATOM   4449 N N   . PRO C 3 353 ? 214.823 198.810 165.464 1.00 51.66 ? 353 PRO A N   1 
ATOM   4450 C CA  . PRO C 3 353 ? 215.357 198.132 166.647 1.00 51.66 ? 353 PRO A CA  1 
ATOM   4451 C C   . PRO C 3 353 ? 216.183 199.060 167.520 1.00 51.66 ? 353 PRO A C   1 
ATOM   4452 O O   . PRO C 3 353 ? 216.748 200.054 167.060 1.00 51.66 ? 353 PRO A O   1 
ATOM   4453 C CB  . PRO C 3 353 ? 216.225 197.019 166.051 1.00 51.66 ? 353 PRO A CB  1 
ATOM   4454 C CG  . PRO C 3 353 ? 216.613 197.527 164.721 1.00 51.66 ? 353 PRO A CG  1 
ATOM   4455 C CD  . PRO C 3 353 ? 215.452 198.332 164.223 1.00 51.66 ? 353 PRO A CD  1 
ATOM   4456 N N   . VAL C 3 354 ? 216.256 198.708 168.803 1.00 50.49 ? 354 VAL A N   1 
ATOM   4457 C CA  . VAL C 3 354 ? 216.886 199.536 169.823 1.00 50.49 ? 354 VAL A CA  1 
ATOM   4458 C C   . VAL C 3 354 ? 217.977 198.775 170.569 1.00 50.49 ? 354 VAL A C   1 
ATOM   4459 O O   . VAL C 3 354 ? 219.108 199.253 170.694 1.00 50.49 ? 354 VAL A O   1 
ATOM   4460 C CB  . VAL C 3 354 ? 215.842 200.100 170.807 1.00 50.49 ? 354 VAL A CB  1 
ATOM   4461 C CG1 . VAL C 3 354 ? 216.524 200.809 171.955 1.00 50.49 ? 354 VAL A CG1 1 
ATOM   4462 C CG2 . VAL C 3 354 ? 214.904 201.031 170.080 1.00 50.49 ? 354 VAL A CG2 1 
ATOM   4463 N N   . ALA C 3 355 ? 217.655 197.589 171.078 1.00 48.29 ? 355 ALA A N   1 
ATOM   4464 C CA  . ALA C 3 355 ? 218.620 196.753 171.774 1.00 48.29 ? 355 ALA A CA  1 
ATOM   4465 C C   . ALA C 3 355 ? 218.639 195.370 171.141 1.00 48.29 ? 355 ALA A C   1 
ATOM   4466 O O   . ALA C 3 355 ? 217.662 194.935 170.529 1.00 48.29 ? 355 ALA A O   1 
ATOM   4467 C CB  . ALA C 3 355 ? 218.301 196.647 173.268 1.00 48.29 ? 355 ALA A CB  1 
ATOM   4468 N N   . MET C 3 356 ? 219.766 194.677 171.288 1.00 49.45 ? 356 MET A N   1 
ATOM   4469 C CA  . MET C 3 356 ? 219.925 193.389 170.628 1.00 49.45 ? 356 MET A CA  1 
ATOM   4470 C C   . MET C 3 356 ? 220.943 192.537 171.374 1.00 49.45 ? 356 MET A C   1 
ATOM   4471 O O   . MET C 3 356 ? 221.983 193.039 171.806 1.00 49.45 ? 356 MET A O   1 
ATOM   4472 C CB  . MET C 3 356 ? 220.355 193.576 169.169 1.00 49.45 ? 356 MET A CB  1 
ATOM   4473 C CG  . MET C 3 356 ? 220.959 192.341 168.529 1.00 49.45 ? 356 MET A CG  1 
ATOM   4474 S SD  . MET C 3 356 ? 219.765 191.424 167.540 1.00 49.45 ? 356 MET A SD  1 
ATOM   4475 C CE  . MET C 3 356 ? 219.152 192.717 166.465 1.00 49.45 ? 356 MET A CE  1 
ATOM   4476 N N   . GLU C 3 357 ? 220.632 191.250 171.519 1.00 50.67 ? 357 GLU A N   1 
ATOM   4477 C CA  . GLU C 3 357 ? 221.535 190.268 172.101 1.00 50.67 ? 357 GLU A CA  1 
ATOM   4478 C C   . GLU C 3 357 ? 221.672 189.096 171.141 1.00 50.67 ? 357 GLU A C   1 
ATOM   4479 O O   . GLU C 3 357 ? 220.700 188.706 170.488 1.00 50.67 ? 357 GLU A O   1 
ATOM   4480 C CB  . GLU C 3 357 ? 221.027 189.784 173.463 1.00 50.67 ? 357 GLU A CB  1 
ATOM   4481 C CG  . GLU C 3 357 ? 221.209 190.759 174.640 1.00 50.67 ? 357 GLU A CG  1 
ATOM   4482 C CD  . GLU C 3 357 ? 222.658 191.139 174.959 1.00 50.67 ? 357 GLU A CD  1 
ATOM   4483 O OE1 . GLU C 3 357 ? 222.919 191.475 176.132 1.00 50.67 ? 357 GLU A OE1 1 
ATOM   4484 O OE2 . GLU C 3 357 ? 223.536 191.111 174.071 1.00 50.67 ? 357 GLU A OE2 1 
ATOM   4485 N N   . GLU C 3 358 ? 222.876 188.535 171.056 1.00 51.40 ? 358 GLU A N   1 
ATOM   4486 C CA  . GLU C 3 358 ? 223.219 187.538 170.044 1.00 51.40 ? 358 GLU A CA  1 
ATOM   4487 C C   . GLU C 3 358 ? 223.946 186.355 170.669 1.00 51.40 ? 358 GLU A C   1 
ATOM   4488 O O   . GLU C 3 358 ? 225.012 185.936 170.215 1.00 51.40 ? 358 GLU A O   1 
ATOM   4489 C CB  . GLU C 3 358 ? 224.060 188.157 168.936 1.00 51.40 ? 358 GLU A CB  1 
ATOM   4490 C CG  . GLU C 3 358 ? 223.949 187.438 167.606 1.00 51.40 ? 358 GLU A CG  1 
ATOM   4491 C CD  . GLU C 3 358 ? 223.948 188.389 166.430 1.00 51.40 ? 358 GLU A CD  1 
ATOM   4492 O OE1 . GLU C 3 358 ? 223.962 189.617 166.658 1.00 51.40 ? 358 GLU A OE1 1 
ATOM   4493 O OE2 . GLU C 3 358 ? 223.932 187.911 165.278 1.00 51.40 ? 358 GLU A OE2 1 
ATOM   4494 N N   . ALA C 3 359 ? 223.370 185.799 171.731 1.00 51.21 ? 359 ALA A N   1 
ATOM   4495 C CA  . ALA C 3 359 ? 223.978 184.664 172.410 1.00 51.21 ? 359 ALA A CA  1 
ATOM   4496 C C   . ALA C 3 359 ? 224.074 183.457 171.482 1.00 51.21 ? 359 ALA A C   1 
ATOM   4497 O O   . ALA C 3 359 ? 223.231 183.245 170.608 1.00 51.21 ? 359 ALA A O   1 
ATOM   4498 C CB  . ALA C 3 359 ? 223.176 184.302 173.657 1.00 51.21 ? 359 ALA A CB  1 
ATOM   4499 N N   . ASP C 3 360 ? 225.118 182.655 171.689 1.00 55.86 ? 360 ASP A N   1 
ATOM   4500 C CA  . ASP C 3 360 ? 225.446 181.519 170.829 1.00 55.86 ? 360 ASP A CA  1 
ATOM   4501 C C   . ASP C 3 360 ? 225.052 180.189 171.455 1.00 55.86 ? 360 ASP A C   1 
ATOM   4502 O O   . ASP C 3 360 ? 225.758 179.187 171.304 1.00 55.86 ? 360 ASP A O   1 
ATOM   4503 C CB  . ASP C 3 360 ? 226.934 181.528 170.496 1.00 55.86 ? 360 ASP A CB  1 
ATOM   4504 C CG  . ASP C 3 360 ? 227.378 182.825 169.857 1.00 55.86 ? 360 ASP A CG  1 
ATOM   4505 O OD1 . ASP C 3 360 ? 226.523 183.527 169.280 1.00 55.86 ? 360 ASP A OD1 1 
ATOM   4506 O OD2 . ASP C 3 360 ? 228.583 183.143 169.933 1.00 55.86 ? 360 ASP A OD2 1 
ATOM   4507 N N   . ASP C 3 361 ? 223.929 180.150 172.161 1.00 54.90 ? 361 ASP A N   1 
ATOM   4508 C CA  . ASP C 3 361 ? 223.477 178.926 172.800 1.00 54.90 ? 361 ASP A CA  1 
ATOM   4509 C C   . ASP C 3 361 ? 222.966 177.931 171.761 1.00 54.90 ? 361 ASP A C   1 
ATOM   4510 O O   . ASP C 3 361 ? 222.475 178.303 170.693 1.00 54.90 ? 361 ASP A O   1 
ATOM   4511 C CB  . ASP C 3 361 ? 222.381 179.248 173.809 1.00 54.90 ? 361 ASP A CB  1 
ATOM   4512 C CG  . ASP C 3 361 ? 222.796 180.335 174.772 1.00 54.90 ? 361 ASP A CG  1 
ATOM   4513 O OD1 . ASP C 3 361 ? 221.975 180.724 175.624 1.00 54.90 ? 361 ASP A OD1 1 
ATOM   4514 O OD2 . ASP C 3 361 ? 223.949 180.804 174.670 1.00 54.90 ? 361 ASP A OD2 1 
ATOM   4515 N N   . THR C 3 362 ? 223.082 176.645 172.090 1.00 55.88 ? 362 THR A N   1 
ATOM   4516 C CA  . THR C 3 362 ? 222.683 175.571 171.192 1.00 55.88 ? 362 THR A CA  1 
ATOM   4517 C C   . THR C 3 362 ? 221.719 174.628 171.895 1.00 55.88 ? 362 THR A C   1 
ATOM   4518 O O   . THR C 3 362 ? 221.845 174.363 173.093 1.00 55.88 ? 362 THR A O   1 
ATOM   4519 C CB  . THR C 3 362 ? 223.892 174.773 170.686 1.00 55.88 ? 362 THR A CB  1 
ATOM   4520 O OG1 . THR C 3 362 ? 224.577 174.183 171.798 1.00 55.88 ? 362 THR A OG1 1 
ATOM   4521 C CG2 . THR C 3 362 ? 224.851 175.678 169.924 1.00 55.88 ? 362 THR A CG2 1 
ATOM   4522 N N   . VAL C 3 363 ? 220.755 174.119 171.133 1.00 55.18 ? 363 VAL A N   1 
ATOM   4523 C CA  . VAL C 3 363 ? 219.756 173.179 171.628 1.00 55.18 ? 363 VAL A CA  1 
ATOM   4524 C C   . VAL C 3 363 ? 219.886 171.885 170.837 1.00 55.18 ? 363 VAL A C   1 
ATOM   4525 O O   . VAL C 3 363 ? 219.697 171.875 169.615 1.00 55.18 ? 363 VAL A O   1 
ATOM   4526 C CB  . VAL C 3 363 ? 218.333 173.745 171.519 1.00 55.18 ? 363 VAL A CB  1 
ATOM   4527 C CG1 . VAL C 3 363 ? 217.410 173.031 172.487 1.00 55.18 ? 363 VAL A CG1 1 
ATOM   4528 C CG2 . VAL C 3 363 ? 218.337 175.236 171.796 1.00 55.18 ? 363 VAL A CG2 1 
ATOM   4529 N N   . ALA C 3 364 ? 220.199 170.798 171.534 1.00 56.99 ? 364 ALA A N   1 
ATOM   4530 C CA  . ALA C 3 364 ? 220.385 169.512 170.892 1.00 56.99 ? 364 ALA A CA  1 
ATOM   4531 C C   . ALA C 3 364 ? 219.039 168.918 170.486 1.00 56.99 ? 364 ALA A C   1 
ATOM   4532 O O   . ALA C 3 364 ? 217.993 169.320 170.999 1.00 56.99 ? 364 ALA A O   1 
ATOM   4533 C CB  . ALA C 3 364 ? 221.121 168.559 171.830 1.00 56.99 ? 364 ALA A CB  1 
ATOM   4534 N N   . PRO C 3 365 ? 219.036 167.973 169.546 1.00 56.64 ? 365 PRO A N   1 
ATOM   4535 C CA  . PRO C 3 365 ? 217.790 167.270 169.224 1.00 56.64 ? 365 PRO A CA  1 
ATOM   4536 C C   . PRO C 3 365 ? 217.241 166.538 170.439 1.00 56.64 ? 365 PRO A C   1 
ATOM   4537 O O   . PRO C 3 365 ? 217.989 165.957 171.228 1.00 56.64 ? 365 PRO A O   1 
ATOM   4538 C CB  . PRO C 3 365 ? 218.208 166.294 168.121 1.00 56.64 ? 365 PRO A CB  1 
ATOM   4539 C CG  . PRO C 3 365 ? 219.426 166.890 167.533 1.00 56.64 ? 365 PRO A CG  1 
ATOM   4540 C CD  . PRO C 3 365 ? 220.136 167.574 168.654 1.00 56.64 ? 365 PRO A CD  1 
ATOM   4541 N N   . SER C 3 366 ? 215.915 166.569 170.577 1.00 56.03 ? 366 SER A N   1 
ATOM   4542 C CA  . SER C 3 366 ? 215.213 165.907 171.677 1.00 56.03 ? 366 SER A CA  1 
ATOM   4543 C C   . SER C 3 366 ? 215.745 166.365 173.034 1.00 56.03 ? 366 SER A C   1 
ATOM   4544 O O   . SER C 3 366 ? 216.000 165.560 173.930 1.00 56.03 ? 366 SER A O   1 
ATOM   4545 C CB  . SER C 3 366 ? 215.300 164.385 171.542 1.00 56.03 ? 366 SER A CB  1 
ATOM   4546 O OG  . SER C 3 366 ? 214.887 163.965 170.254 1.00 56.03 ? 366 SER A OG  1 
ATOM   4547 N N   . SER C 3 367 ? 215.907 167.679 173.185 1.00 54.16 ? 367 SER A N   1 
ATOM   4548 C CA  . SER C 3 367 ? 216.500 168.243 174.389 1.00 54.16 ? 367 SER A CA  1 
ATOM   4549 C C   . SER C 3 367 ? 215.691 169.450 174.842 1.00 54.16 ? 367 SER A C   1 
ATOM   4550 O O   . SER C 3 367 ? 214.698 169.833 174.219 1.00 54.16 ? 367 SER A O   1 
ATOM   4551 C CB  . SER C 3 367 ? 217.964 168.627 174.155 1.00 54.16 ? 367 SER A CB  1 
ATOM   4552 O OG  . SER C 3 367 ? 218.522 169.217 175.315 1.00 54.16 ? 367 SER A OG  1 
ATOM   4553 N N   . THR C 3 368 ? 216.134 170.053 175.942 1.00 51.53 ? 368 THR A N   1 
ATOM   4554 C CA  . THR C 3 368 ? 215.463 171.193 176.544 1.00 51.53 ? 368 THR A CA  1 
ATOM   4555 C C   . THR C 3 368 ? 216.494 172.250 176.916 1.00 51.53 ? 368 THR A C   1 
ATOM   4556 O O   . THR C 3 368 ? 217.627 171.932 177.286 1.00 51.53 ? 368 THR A O   1 
ATOM   4557 C CB  . THR C 3 368 ? 214.662 170.775 177.783 1.00 51.53 ? 368 THR A CB  1 
ATOM   4558 O OG1 . THR C 3 368 ? 213.909 169.595 177.484 1.00 51.53 ? 368 THR A OG1 1 
ATOM   4559 C CG2 . THR C 3 368 ? 213.708 171.877 178.204 1.00 51.53 ? 368 THR A CG2 1 
ATOM   4560 N N   . PHE C 3 369 ? 216.090 173.514 176.809 1.00 49.40 ? 369 PHE A N   1 
ATOM   4561 C CA  . PHE C 3 369 ? 216.948 174.645 177.124 1.00 49.40 ? 369 PHE A CA  1 
ATOM   4562 C C   . PHE C 3 369 ? 216.127 175.698 177.851 1.00 49.40 ? 369 PHE A C   1 
ATOM   4563 O O   . PHE C 3 369 ? 214.922 175.827 177.625 1.00 49.40 ? 369 PHE A O   1 
ATOM   4564 C CB  . PHE C 3 369 ? 217.575 175.229 175.856 1.00 49.40 ? 369 PHE A CB  1 
ATOM   4565 C CG  . PHE C 3 369 ? 218.302 176.518 176.076 1.00 49.40 ? 369 PHE A CG  1 
ATOM   4566 C CD1 . PHE C 3 369 ? 219.514 176.537 176.739 1.00 49.40 ? 369 PHE A CD1 1 
ATOM   4567 C CD2 . PHE C 3 369 ? 217.782 177.708 175.608 1.00 49.40 ? 369 PHE A CD2 1 
ATOM   4568 C CE1 . PHE C 3 369 ? 220.189 177.719 176.939 1.00 49.40 ? 369 PHE A CE1 1 
ATOM   4569 C CE2 . PHE C 3 369 ? 218.452 178.894 175.805 1.00 49.40 ? 369 PHE A CE2 1 
ATOM   4570 C CZ  . PHE C 3 369 ? 219.657 178.899 176.472 1.00 49.40 ? 369 PHE A CZ  1 
ATOM   4571 N N   . CYS C 3 370 ? 216.786 176.449 178.733 1.00 47.10 ? 370 CYS A N   1 
ATOM   4572 C CA  . CYS C 3 370 ? 216.106 177.491 179.493 1.00 47.10 ? 370 CYS A CA  1 
ATOM   4573 C C   . CYS C 3 370 ? 217.137 178.455 180.051 1.00 47.10 ? 370 CYS A C   1 
ATOM   4574 O O   . CYS C 3 370 ? 218.101 178.027 180.690 1.00 47.10 ? 370 CYS A O   1 
ATOM   4575 C CB  . CYS C 3 370 ? 215.277 176.896 180.631 1.00 47.10 ? 370 CYS A CB  1 
ATOM   4576 S SG  . CYS C 3 370 ? 214.656 178.119 181.804 1.00 47.10 ? 370 CYS A SG  1 
ATOM   4577 N N   . LYS C 3 371 ? 216.929 179.747 179.818 1.00 47.38 ? 371 LYS A N   1 
ATOM   4578 C CA  . LYS C 3 371 ? 217.780 180.774 180.402 1.00 47.38 ? 371 LYS A CA  1 
ATOM   4579 C C   . LYS C 3 371 ? 217.016 182.089 180.410 1.00 47.38 ? 371 LYS A C   1 
ATOM   4580 O O   . LYS C 3 371 ? 215.963 182.222 179.783 1.00 47.38 ? 371 LYS A O   1 
ATOM   4581 C CB  . LYS C 3 371 ? 219.106 180.906 179.647 1.00 47.38 ? 371 LYS A CB  1 
ATOM   4582 C CG  . LYS C 3 371 ? 220.242 181.437 180.507 1.00 47.38 ? 371 LYS A CG  1 
ATOM   4583 C CD  . LYS C 3 371 ? 221.560 180.751 180.201 1.00 47.38 ? 371 LYS A CD  1 
ATOM   4584 C CE  . LYS C 3 371 ? 221.848 180.738 178.716 1.00 47.38 ? 371 LYS A CE  1 
ATOM   4585 N NZ  . LYS C 3 371 ? 221.897 182.112 178.141 1.00 47.38 ? 371 LYS A NZ  1 
ATOM   4586 N N   . VAL C 3 372 ? 217.557 183.059 181.139 1.00 44.38 ? 372 VAL A N   1 
ATOM   4587 C CA  . VAL C 3 372 ? 216.974 184.390 181.248 1.00 44.38 ? 372 VAL A CA  1 
ATOM   4588 C C   . VAL C 3 372 ? 217.945 185.382 180.631 1.00 44.38 ? 372 VAL A C   1 
ATOM   4589 O O   . VAL C 3 372 ? 219.115 185.443 181.028 1.00 44.38 ? 372 VAL A O   1 
ATOM   4590 C CB  . VAL C 3 372 ? 216.665 184.759 182.704 1.00 44.38 ? 372 VAL A CB  1 
ATOM   4591 C CG1 . VAL C 3 372 ? 216.058 186.141 182.774 1.00 44.38 ? 372 VAL A CG1 1 
ATOM   4592 C CG2 . VAL C 3 372 ? 215.727 183.735 183.310 1.00 44.38 ? 372 VAL A CG2 1 
ATOM   4593 N N   . TYR C 3 373 ? 217.460 186.157 179.668 1.00 45.98 ? 373 TYR A N   1 
ATOM   4594 C CA  . TYR C 3 373 ? 218.260 187.127 178.935 1.00 45.98 ? 373 TYR A CA  1 
ATOM   4595 C C   . TYR C 3 373 ? 217.801 188.525 179.319 1.00 45.98 ? 373 TYR A C   1 
ATOM   4596 O O   . TYR C 3 373 ? 216.609 188.836 179.223 1.00 45.98 ? 373 TYR A O   1 
ATOM   4597 C CB  . TYR C 3 373 ? 218.118 186.921 177.425 1.00 45.98 ? 373 TYR A CB  1 
ATOM   4598 C CG  . TYR C 3 373 ? 218.598 185.580 176.910 1.00 45.98 ? 373 TYR A CG  1 
ATOM   4599 C CD1 . TYR C 3 373 ? 217.961 184.403 177.264 1.00 45.98 ? 373 TYR A CD1 1 
ATOM   4600 C CD2 . TYR C 3 373 ? 219.677 185.499 176.044 1.00 45.98 ? 373 TYR A CD2 1 
ATOM   4601 C CE1 . TYR C 3 373 ? 218.397 183.186 176.794 1.00 45.98 ? 373 TYR A CE1 1 
ATOM   4602 C CE2 . TYR C 3 373 ? 220.117 184.286 175.565 1.00 45.98 ? 373 TYR A CE2 1 
ATOM   4603 C CZ  . TYR C 3 373 ? 219.474 183.133 175.943 1.00 45.98 ? 373 TYR A CZ  1 
ATOM   4604 O OH  . TYR C 3 373 ? 219.910 181.921 175.467 1.00 45.98 ? 373 TYR A OH  1 
ATOM   4605 N N   . THR C 3 374 ? 218.738 189.364 179.752 1.00 47.37 ? 374 THR A N   1 
ATOM   4606 C CA  . THR C 3 374 ? 218.426 190.704 180.236 1.00 47.37 ? 374 THR A CA  1 
ATOM   4607 C C   . THR C 3 374 ? 219.150 191.730 179.379 1.00 47.37 ? 374 THR A C   1 
ATOM   4608 O O   . THR C 3 374 ? 220.380 191.698 179.276 1.00 47.37 ? 374 THR A O   1 
ATOM   4609 C CB  . THR C 3 374 ? 218.828 190.865 181.702 1.00 47.37 ? 374 THR A CB  1 
ATOM   4610 O OG1 . THR C 3 374 ? 220.251 191.004 181.793 1.00 47.37 ? 374 THR A OG1 1 
ATOM   4611 C CG2 . THR C 3 374 ? 218.395 189.654 182.512 1.00 47.37 ? 374 THR A CG2 1 
ATOM   4612 N N   . LEU C 3 375 ? 218.392 192.645 178.781 1.00 47.98 ? 375 LEU A N   1 
ATOM   4613 C CA  . LEU C 3 375 ? 218.949 193.694 177.941 1.00 47.98 ? 375 LEU A CA  1 
ATOM   4614 C C   . LEU C 3 375 ? 218.345 195.037 178.324 1.00 47.98 ? 375 LEU A C   1 
ATOM   4615 O O   . LEU C 3 375 ? 217.197 195.116 178.767 1.00 47.98 ? 375 LEU A O   1 
ATOM   4616 C CB  . LEU C 3 375 ? 218.716 193.419 176.446 1.00 47.98 ? 375 LEU A CB  1 
ATOM   4617 C CG  . LEU C 3 375 ? 217.341 193.545 175.790 1.00 47.98 ? 375 LEU A CG  1 
ATOM   4618 C CD1 . LEU C 3 375 ? 217.431 193.052 174.359 1.00 47.98 ? 375 LEU A CD1 1 
ATOM   4619 C CD2 . LEU C 3 375 ? 216.251 192.794 176.533 1.00 47.98 ? 375 LEU A CD2 1 
ATOM   4620 N N   . THR C 3 376 ? 219.134 196.094 178.148 1.00 50.39 ? 376 THR A N   1 
ATOM   4621 C CA  . THR C 3 376 ? 218.750 197.445 178.537 1.00 50.39 ? 376 THR A CA  1 
ATOM   4622 C C   . THR C 3 376 ? 218.677 198.341 177.309 1.00 50.39 ? 376 THR A C   1 
ATOM   4623 O O   . THR C 3 376 ? 219.710 198.574 176.659 1.00 50.39 ? 376 THR A O   1 
ATOM   4624 C CB  . THR C 3 376 ? 219.748 198.017 179.546 1.00 50.39 ? 376 THR A CB  1 
ATOM   4625 O OG1 . THR C 3 376 ? 219.738 197.222 180.737 1.00 50.39 ? 376 THR A OG1 1 
ATOM   4626 C CG2 . THR C 3 376 ? 219.388 199.451 179.895 1.00 50.39 ? 376 THR A CG2 1 
ATOM   4627 N N   . PRO C 3 377 ? 217.512 198.861 176.947 1.00 51.87 ? 377 PRO A N   1 
ATOM   4628 C CA  . PRO C 3 377 ? 217.441 199.767 175.798 1.00 51.87 ? 377 PRO A CA  1 
ATOM   4629 C C   . PRO C 3 377 ? 217.711 201.209 176.188 1.00 51.87 ? 377 PRO A C   1 
ATOM   4630 O O   . PRO C 3 377 ? 217.032 201.752 177.064 1.00 51.87 ? 377 PRO A O   1 
ATOM   4631 C CB  . PRO C 3 377 ? 216.007 199.574 175.299 1.00 51.87 ? 377 PRO A CB  1 
ATOM   4632 C CG  . PRO C 3 377 ? 215.240 199.222 176.522 1.00 51.87 ? 377 PRO A CG  1 
ATOM   4633 C CD  . PRO C 3 377 ? 216.179 198.532 177.475 1.00 51.87 ? 377 PRO A CD  1 
ATOM   4634 N N   . PHE C 3 378 ? 218.699 201.839 175.556 1.00 58.45 ? 378 PHE A N   1 
ATOM   4635 C CA  . PHE C 3 378 ? 218.988 203.245 175.810 1.00 58.45 ? 378 PHE A CA  1 
ATOM   4636 C C   . PHE C 3 378 ? 219.734 203.835 174.619 1.00 58.45 ? 378 PHE A C   1 
ATOM   4637 O O   . PHE C 3 378 ? 220.243 203.117 173.757 1.00 58.45 ? 378 PHE A O   1 
ATOM   4638 C CB  . PHE C 3 378 ? 219.734 203.433 177.141 1.00 58.45 ? 378 PHE A CB  1 
ATOM   4639 C CG  . PHE C 3 378 ? 221.210 203.180 177.075 1.00 58.45 ? 378 PHE A CG  1 
ATOM   4640 C CD1 . PHE C 3 378 ? 221.717 202.069 176.424 1.00 58.45 ? 378 PHE A CD1 1 
ATOM   4641 C CD2 . PHE C 3 378 ? 222.093 204.044 177.697 1.00 58.45 ? 378 PHE A CD2 1 
ATOM   4642 C CE1 . PHE C 3 378 ? 223.077 201.833 176.384 1.00 58.45 ? 378 PHE A CE1 1 
ATOM   4643 C CE2 . PHE C 3 378 ? 223.456 203.815 177.658 1.00 58.45 ? 378 PHE A CE2 1 
ATOM   4644 C CZ  . PHE C 3 378 ? 223.948 202.708 176.998 1.00 58.45 ? 378 PHE A CZ  1 
ATOM   4645 N N   . LEU C 3 379 ? 219.781 205.168 174.588 1.00 58.12 ? 379 LEU A N   1 
ATOM   4646 C CA  . LEU C 3 379 ? 220.043 205.941 173.379 1.00 58.12 ? 379 LEU A CA  1 
ATOM   4647 C C   . LEU C 3 379 ? 221.513 206.021 172.987 1.00 58.12 ? 379 LEU A C   1 
ATOM   4648 O O   . LEU C 3 379 ? 221.805 206.447 171.866 1.00 58.12 ? 379 LEU A O   1 
ATOM   4649 C CB  . LEU C 3 379 ? 219.495 207.359 173.558 1.00 58.12 ? 379 LEU A CB  1 
ATOM   4650 C CG  . LEU C 3 379 ? 219.281 208.219 172.314 1.00 58.12 ? 379 LEU A CG  1 
ATOM   4651 C CD1 . LEU C 3 379 ? 218.717 207.386 171.192 1.00 58.12 ? 379 LEU A CD1 1 
ATOM   4652 C CD2 . LEU C 3 379 ? 218.360 209.385 172.624 1.00 58.12 ? 379 LEU A CD2 1 
ATOM   4653 N N   . ALA C 3 380 ? 222.440 205.627 173.861 1.00 60.49 ? 380 ALA A N   1 
ATOM   4654 C CA  . ALA C 3 380 ? 223.856 205.862 173.586 1.00 60.49 ? 380 ALA A CA  1 
ATOM   4655 C C   . ALA C 3 380 ? 224.296 205.166 172.303 1.00 60.49 ? 380 ALA A C   1 
ATOM   4656 O O   . ALA C 3 380 ? 225.024 205.744 171.488 1.00 60.49 ? 380 ALA A O   1 
ATOM   4657 C CB  . ALA C 3 380 ? 224.705 205.401 174.769 1.00 60.49 ? 380 ALA A CB  1 
ATOM   4658 N N   . ASN C 3 381 ? 223.859 203.925 172.103 1.00 61.51 ? 381 ASN A N   1 
ATOM   4659 C CA  . ASN C 3 381 ? 224.209 203.182 170.900 1.00 61.51 ? 381 ASN A CA  1 
ATOM   4660 C C   . ASN C 3 381 ? 223.309 203.505 169.718 1.00 61.51 ? 381 ASN A C   1 
ATOM   4661 O O   . ASN C 3 381 ? 223.564 203.010 168.615 1.00 61.51 ? 381 ASN A O   1 
ATOM   4662 C CB  . ASN C 3 381 ? 224.153 201.682 171.182 1.00 61.51 ? 381 ASN A CB  1 
ATOM   4663 C CG  . ASN C 3 381 ? 222.767 201.219 171.549 1.00 61.51 ? 381 ASN A CG  1 
ATOM   4664 O OD1 . ASN C 3 381 ? 221.889 202.030 171.829 1.00 61.51 ? 381 ASN A OD1 1 
ATOM   4665 N ND2 . ASN C 3 381 ? 222.558 199.908 171.551 1.00 61.51 ? 381 ASN A ND2 1 
ATOM   4666 N N   . ASN C 3 382 ? 222.273 204.316 169.915 1.00 61.63 ? 382 ASN A N   1 
ATOM   4667 C CA  . ASN C 3 382 ? 221.271 204.575 168.890 1.00 61.63 ? 382 ASN A CA  1 
ATOM   4668 C C   . ASN C 3 382 ? 221.312 206.017 168.395 1.00 61.63 ? 382 ASN A C   1 
ATOM   4669 O O   . ASN C 3 382 ? 220.284 206.572 168.002 1.00 61.63 ? 382 ASN A O   1 
ATOM   4670 C CB  . ASN C 3 382 ? 219.880 204.236 169.419 1.00 61.63 ? 382 ASN A CB  1 
ATOM   4671 C CG  . ASN C 3 382 ? 219.677 202.751 169.611 1.00 61.63 ? 382 ASN A CG  1 
ATOM   4672 O OD1 . ASN C 3 382 ? 218.648 202.319 170.123 1.00 61.63 ? 382 ASN A OD1 1 
ATOM   4673 N ND2 . ASN C 3 382 ? 220.657 201.959 169.197 1.00 61.63 ? 382 ASN A ND2 1 
ATOM   4674 N N   . ARG C 3 383 ? 222.492 206.637 168.410 1.00 65.07 ? 383 ARG A N   1 
ATOM   4675 C CA  . ARG C 3 383 ? 222.602 208.017 167.956 1.00 65.07 ? 383 ARG A CA  1 
ATOM   4676 C C   . ARG C 3 383 ? 222.484 208.142 166.443 1.00 65.07 ? 383 ARG A C   1 
ATOM   4677 O O   . ARG C 3 383 ? 222.165 209.227 165.949 1.00 65.07 ? 383 ARG A O   1 
ATOM   4678 C CB  . ARG C 3 383 ? 223.926 208.619 168.427 1.00 65.07 ? 383 ARG A CB  1 
ATOM   4679 C CG  . ARG C 3 383 ? 223.949 208.985 169.899 1.00 65.07 ? 383 ARG A CG  1 
ATOM   4680 C CD  . ARG C 3 383 ? 222.874 209.997 170.240 1.00 65.07 ? 383 ARG A CD  1 
ATOM   4681 N NE  . ARG C 3 383 ? 223.413 211.348 170.323 1.00 65.07 ? 383 ARG A NE  1 
ATOM   4682 C CZ  . ARG C 3 383 ? 223.905 211.889 171.430 1.00 65.07 ? 383 ARG A CZ  1 
ATOM   4683 N NH1 . ARG C 3 383 ? 223.948 211.215 172.568 1.00 65.07 ? 383 ARG A NH1 1 
ATOM   4684 N NH2 . ARG C 3 383 ? 224.367 213.135 171.393 1.00 65.07 ? 383 ARG A NH2 1 
ATOM   4685 N N   . GLU C 3 384 ? 222.733 207.066 165.700 1.00 65.46 ? 384 GLU A N   1 
ATOM   4686 C CA  . GLU C 3 384 ? 222.709 207.102 164.244 1.00 65.46 ? 384 GLU A CA  1 
ATOM   4687 C C   . GLU C 3 384 ? 221.395 206.613 163.648 1.00 65.46 ? 384 GLU A C   1 
ATOM   4688 O O   . GLU C 3 384 ? 221.268 206.577 162.421 1.00 65.46 ? 384 GLU A O   1 
ATOM   4689 C CB  . GLU C 3 384 ? 223.864 206.271 163.661 1.00 65.46 ? 384 GLU A CB  1 
ATOM   4690 C CG  . GLU C 3 384 ? 225.282 206.826 163.866 1.00 65.46 ? 384 GLU A CG  1 
ATOM   4691 C CD  . GLU C 3 384 ? 225.679 207.033 165.321 1.00 65.46 ? 384 GLU A CD  1 
ATOM   4692 O OE1 . GLU C 3 384 ? 226.726 207.669 165.562 1.00 65.46 ? 384 GLU A OE1 1 
ATOM   4693 O OE2 . GLU C 3 384 ? 224.982 206.522 166.223 1.00 65.46 ? 384 GLU A OE2 1 
ATOM   4694 N N   . LYS C 3 385 ? 220.424 206.230 164.475 1.00 64.13 ? 385 LYS A N   1 
ATOM   4695 C CA  . LYS C 3 385 ? 219.151 205.752 163.954 1.00 64.13 ? 385 LYS A CA  1 
ATOM   4696 C C   . LYS C 3 385 ? 218.429 206.872 163.219 1.00 64.13 ? 385 LYS A C   1 
ATOM   4697 O O   . LYS C 3 385 ? 218.491 208.039 163.616 1.00 64.13 ? 385 LYS A O   1 
ATOM   4698 C CB  . LYS C 3 385 ? 218.287 205.214 165.091 1.00 64.13 ? 385 LYS A CB  1 
ATOM   4699 C CG  . LYS C 3 385 ? 218.975 204.151 165.933 1.00 64.13 ? 385 LYS A CG  1 
ATOM   4700 C CD  . LYS C 3 385 ? 219.276 202.899 165.126 1.00 64.13 ? 385 LYS A CD  1 
ATOM   4701 C CE  . LYS C 3 385 ? 219.657 201.742 166.037 1.00 64.13 ? 385 LYS A CE  1 
ATOM   4702 N NZ  . LYS C 3 385 ? 220.037 200.521 165.278 1.00 64.13 ? 385 LYS A NZ  1 
ATOM   4703 N N   . ARG C 3 386 ? 217.738 206.516 162.138 1.00 69.17 ? 386 ARG A N   1 
ATOM   4704 C CA  . ARG C 3 386 ? 217.236 207.523 161.213 1.00 69.17 ? 386 ARG A CA  1 
ATOM   4705 C C   . ARG C 3 386 ? 215.880 208.093 161.603 1.00 69.17 ? 386 ARG A C   1 
ATOM   4706 O O   . ARG C 3 386 ? 215.613 209.266 161.322 1.00 69.17 ? 386 ARG A O   1 
ATOM   4707 C CB  . ARG C 3 386 ? 217.153 206.944 159.799 1.00 69.17 ? 386 ARG A CB  1 
ATOM   4708 C CG  . ARG C 3 386 ? 216.682 207.948 158.758 1.00 69.17 ? 386 ARG A CG  1 
ATOM   4709 C CD  . ARG C 3 386 ? 216.844 207.416 157.344 1.00 69.17 ? 386 ARG A CD  1 
ATOM   4710 N NE  . ARG C 3 386 ? 218.249 207.240 156.994 1.00 69.17 ? 386 ARG A NE  1 
ATOM   4711 C CZ  . ARG C 3 386 ? 218.854 206.065 156.890 1.00 69.17 ? 386 ARG A CZ  1 
ATOM   4712 N NH1 . ARG C 3 386 ? 218.205 204.931 157.100 1.00 69.17 ? 386 ARG A NH1 1 
ATOM   4713 N NH2 . ARG C 3 386 ? 220.144 206.027 156.565 1.00 69.17 ? 386 ARG A NH2 1 
ATOM   4714 N N   . GLY C 3 387 ? 215.016 207.306 162.235 1.00 61.94 ? 387 GLY A N   1 
ATOM   4715 C CA  . GLY C 3 387 ? 213.687 207.787 162.563 1.00 61.94 ? 387 GLY A CA  1 
ATOM   4716 C C   . GLY C 3 387 ? 213.216 207.383 163.942 1.00 61.94 ? 387 GLY A C   1 
ATOM   4717 O O   . GLY C 3 387 ? 212.013 207.344 164.212 1.00 61.94 ? 387 GLY A O   1 
ATOM   4718 N N   . LEU C 3 388 ? 214.161 207.084 164.825 1.00 55.94 ? 388 LEU A N   1 
ATOM   4719 C CA  . LEU C 3 388 ? 213.823 206.636 166.165 1.00 55.94 ? 388 LEU A CA  1 
ATOM   4720 C C   . LEU C 3 388 ? 213.122 207.751 166.932 1.00 55.94 ? 388 LEU A C   1 
ATOM   4721 O O   . LEU C 3 388 ? 213.468 208.928 166.815 1.00 55.94 ? 388 LEU A O   1 
ATOM   4722 C CB  . LEU C 3 388 ? 215.091 206.187 166.888 1.00 55.94 ? 388 LEU A CB  1 
ATOM   4723 C CG  . LEU C 3 388 ? 215.063 205.953 168.389 1.00 55.94 ? 388 LEU A CG  1 
ATOM   4724 C CD1 . LEU C 3 388 ? 214.378 204.638 168.676 1.00 55.94 ? 388 LEU A CD1 1 
ATOM   4725 C CD2 . LEU C 3 388 ? 216.470 205.936 168.914 1.00 55.94 ? 388 LEU A CD2 1 
ATOM   4726 N N   . ALA C 3 389 ? 212.116 207.374 167.715 1.00 52.49 ? 389 ALA A N   1 
ATOM   4727 C CA  . ALA C 3 389 ? 211.278 208.342 168.410 1.00 52.49 ? 389 ALA A CA  1 
ATOM   4728 C C   . ALA C 3 389 ? 211.938 208.787 169.708 1.00 52.49 ? 389 ALA A C   1 
ATOM   4729 O O   . ALA C 3 389 ? 212.313 207.955 170.538 1.00 52.49 ? 389 ALA A O   1 
ATOM   4730 C CB  . ALA C 3 389 ? 209.902 207.746 168.696 1.00 52.49 ? 389 ALA A CB  1 
ATOM   4731 N N   . LEU C 3 390 ? 212.069 210.099 169.881 1.00 55.57 ? 390 LEU A N   1 
ATOM   4732 C CA  . LEU C 3 390 ? 212.676 210.697 171.060 1.00 55.57 ? 390 LEU A CA  1 
ATOM   4733 C C   . LEU C 3 390 ? 211.611 211.377 171.911 1.00 55.57 ? 390 LEU A C   1 
ATOM   4734 O O   . LEU C 3 390 ? 210.466 211.552 171.495 1.00 55.57 ? 390 LEU A O   1 
ATOM   4735 C CB  . LEU C 3 390 ? 213.760 211.702 170.661 1.00 55.57 ? 390 LEU A CB  1 
ATOM   4736 C CG  . LEU C 3 390 ? 214.849 211.177 169.729 1.00 55.57 ? 390 LEU A CG  1 
ATOM   4737 C CD1 . LEU C 3 390 ? 215.945 212.210 169.555 1.00 55.57 ? 390 LEU A CD1 1 
ATOM   4738 C CD2 . LEU C 3 390 ? 215.421 209.875 170.260 1.00 55.57 ? 390 LEU A CD2 1 
ATOM   4739 N N   . ASP C 3 391 ? 212.011 211.772 173.118 1.00 58.80 ? 391 ASP A N   1 
ATOM   4740 C CA  . ASP C 3 391 ? 211.050 212.296 174.088 1.00 58.80 ? 391 ASP A CA  1 
ATOM   4741 C C   . ASP C 3 391 ? 210.727 213.764 173.825 1.00 58.80 ? 391 ASP A C   1 
ATOM   4742 O O   . ASP C 3 391 ? 209.574 214.120 173.563 1.00 58.80 ? 391 ASP A O   1 
ATOM   4743 C CB  . ASP C 3 391 ? 211.589 212.100 175.507 1.00 58.80 ? 391 ASP A CB  1 
ATOM   4744 C CG  . ASP C 3 391 ? 210.588 212.501 176.571 1.00 58.80 ? 391 ASP A CG  1 
ATOM   4745 O OD1 . ASP C 3 391 ? 209.514 211.868 176.647 1.00 58.80 ? 391 ASP A OD1 1 
ATOM   4746 O OD2 . ASP C 3 391 ? 210.879 213.445 177.336 1.00 58.80 ? 391 ASP A OD2 1 
ATOM   4747 N N   . GLY C 3 392 ? 211.732 214.628 173.885 1.00 59.77 ? 392 GLY A N   1 
ATOM   4748 C CA  . GLY C 3 392 ? 211.523 216.042 173.630 1.00 59.77 ? 392 GLY A CA  1 
ATOM   4749 C C   . GLY C 3 392 ? 212.576 216.949 174.235 1.00 59.77 ? 392 GLY A C   1 
ATOM   4750 O O   . GLY C 3 392 ? 213.293 217.650 173.520 1.00 59.77 ? 392 GLY A O   1 
ATOM   4751 N N   . ASP C 3 398 ? 219.802 215.574 176.711 1.00 71.32 ? 398 ASP A N   1 
ATOM   4752 C CA  . ASP C 3 398 ? 219.419 214.603 177.729 1.00 71.32 ? 398 ASP A CA  1 
ATOM   4753 C C   . ASP C 3 398 ? 218.156 213.851 177.325 1.00 71.32 ? 398 ASP A C   1 
ATOM   4754 O O   . ASP C 3 398 ? 217.546 213.159 178.137 1.00 71.32 ? 398 ASP A O   1 
ATOM   4755 C CB  . ASP C 3 398 ? 219.214 215.293 179.079 1.00 71.32 ? 398 ASP A CB  1 
ATOM   4756 C CG  . ASP C 3 398 ? 218.198 216.418 179.011 1.00 71.32 ? 398 ASP A CG  1 
ATOM   4757 O OD1 . ASP C 3 398 ? 217.919 216.903 177.894 1.00 71.32 ? 398 ASP A OD1 1 
ATOM   4758 O OD2 . ASP C 3 398 ? 217.679 216.817 180.074 1.00 71.32 ? 398 ASP A OD2 1 
ATOM   4759 N N   . THR C 3 399 ? 217.771 213.996 176.061 1.00 64.39 ? 399 THR A N   1 
ATOM   4760 C CA  . THR C 3 399 ? 216.581 213.332 175.553 1.00 64.39 ? 399 THR A CA  1 
ATOM   4761 C C   . THR C 3 399 ? 216.779 211.820 175.521 1.00 64.39 ? 399 THR A C   1 
ATOM   4762 O O   . THR C 3 399 ? 217.889 211.319 175.332 1.00 64.39 ? 399 THR A O   1 
ATOM   4763 C CB  . THR C 3 399 ? 216.248 213.848 174.152 1.00 64.39 ? 399 THR A CB  1 
ATOM   4764 O OG1 . THR C 3 399 ? 216.389 215.273 174.123 1.00 64.39 ? 399 THR A OG1 1 
ATOM   4765 C CG2 . THR C 3 399 ? 214.825 213.486 173.770 1.00 64.39 ? 399 THR A CG2 1 
ATOM   4766 N N   . ASN C 3 400 ? 215.684 211.092 175.716 1.00 59.33 ? 400 ASN A N   1 
ATOM   4767 C CA  . ASN C 3 400 ? 215.688 209.638 175.718 1.00 59.33 ? 400 ASN A CA  1 
ATOM   4768 C C   . ASN C 3 400 ? 214.616 209.128 174.763 1.00 59.33 ? 400 ASN A C   1 
ATOM   4769 O O   . ASN C 3 400 ? 213.895 209.905 174.130 1.00 59.33 ? 400 ASN A O   1 
ATOM   4770 C CB  . ASN C 3 400 ? 215.468 209.096 177.134 1.00 59.33 ? 400 ASN A CB  1 
ATOM   4771 C CG  . ASN C 3 400 ? 214.487 209.930 177.924 1.00 59.33 ? 400 ASN A CG  1 
ATOM   4772 O OD1 . ASN C 3 400 ? 213.484 210.394 177.391 1.00 59.33 ? 400 ASN A OD1 1 
ATOM   4773 N ND2 . ASN C 3 400 ? 214.772 210.125 179.205 1.00 59.33 ? 400 ASN A ND2 1 
ATOM   4774 N N   . LEU C 3 401 ? 214.518 207.806 174.657 1.00 52.28 ? 401 LEU A N   1 
ATOM   4775 C CA  . LEU C 3 401 ? 213.536 207.194 173.772 1.00 52.28 ? 401 LEU A CA  1 
ATOM   4776 C C   . LEU C 3 401 ? 212.122 207.500 174.244 1.00 52.28 ? 401 LEU A C   1 
ATOM   4777 O O   . LEU C 3 401 ? 211.860 207.608 175.444 1.00 52.28 ? 401 LEU A O   1 
ATOM   4778 C CB  . LEU C 3 401 ? 213.756 205.686 173.705 1.00 52.28 ? 401 LEU A CB  1 
ATOM   4779 C CG  . LEU C 3 401 ? 214.943 205.213 172.874 1.00 52.28 ? 401 LEU A CG  1 
ATOM   4780 C CD1 . LEU C 3 401 ? 216.155 205.004 173.749 1.00 52.28 ? 401 LEU A CD1 1 
ATOM   4781 C CD2 . LEU C 3 401 ? 214.573 203.933 172.182 1.00 52.28 ? 401 LEU A CD2 1 
ATOM   4782 N N   . ALA C 3 402 ? 211.209 207.648 173.288 1.00 51.00 ? 402 ALA A N   1 
ATOM   4783 C CA  . ALA C 3 402 ? 209.854 208.075 173.605 1.00 51.00 ? 402 ALA A CA  1 
ATOM   4784 C C   . ALA C 3 402 ? 209.151 207.047 174.477 1.00 51.00 ? 402 ALA A C   1 
ATOM   4785 O O   . ALA C 3 402 ? 209.179 205.847 174.193 1.00 51.00 ? 402 ALA A O   1 
ATOM   4786 C CB  . ALA C 3 402 ? 209.061 208.305 172.321 1.00 51.00 ? 402 ALA A CB  1 
ATOM   4787 N N   . SER C 3 403 ? 208.521 207.524 175.544 1.00 50.26 ? 403 SER A N   1 
ATOM   4788 C CA  . SER C 3 403 ? 207.735 206.653 176.399 1.00 50.26 ? 403 SER A CA  1 
ATOM   4789 C C   . SER C 3 403 ? 206.505 206.154 175.655 1.00 50.26 ? 403 SER A C   1 
ATOM   4790 O O   . SER C 3 403 ? 205.924 206.861 174.831 1.00 50.26 ? 403 SER A O   1 
ATOM   4791 C CB  . SER C 3 403 ? 207.317 207.392 177.665 1.00 50.26 ? 403 SER A CB  1 
ATOM   4792 O OG  . SER C 3 403 ? 208.399 208.138 178.193 1.00 50.26 ? 403 SER A OG  1 
ATOM   4793 N N   . SER C 3 404 ? 206.105 204.924 175.962 1.00 52.06 ? 404 SER A N   1 
ATOM   4794 C CA  . SER C 3 404 ? 204.999 204.302 175.250 1.00 52.06 ? 404 SER A CA  1 
ATOM   4795 C C   . SER C 3 404 ? 203.715 205.090 175.451 1.00 52.06 ? 404 SER A C   1 
ATOM   4796 O O   . SER C 3 404 ? 203.423 205.570 176.549 1.00 52.06 ? 404 SER A O   1 
ATOM   4797 C CB  . SER C 3 404 ? 204.803 202.865 175.722 1.00 52.06 ? 404 SER A CB  1 
ATOM   4798 O OG  . SER C 3 404 ? 204.623 202.820 177.123 1.00 52.06 ? 404 SER A OG  1 
ATOM   4799 N N   . THR C 3 405 ? 202.947 205.225 174.376 1.00 58.17 ? 405 THR A N   1 
ATOM   4800 C CA  . THR C 3 405 ? 201.705 205.977 174.425 1.00 58.17 ? 405 THR A CA  1 
ATOM   4801 C C   . THR C 3 405 ? 200.612 205.155 175.093 1.00 58.17 ? 405 THR A C   1 
ATOM   4802 O O   . THR C 3 405 ? 200.424 203.979 174.772 1.00 58.17 ? 405 THR A O   1 
ATOM   4803 C CB  . THR C 3 405 ? 201.269 206.372 173.021 1.00 58.17 ? 405 THR A CB  1 
ATOM   4804 O OG1 . THR C 3 405 ? 202.279 207.190 172.419 1.00 58.17 ? 405 THR A OG1 1 
ATOM   4805 C CG2 . THR C 3 405 ? 199.965 207.144 173.082 1.00 58.17 ? 405 THR A CG2 1 
ATOM   4806 N N   . LEU C 3 406 ? 199.894 205.774 176.025 1.00 64.61 ? 406 LEU A N   1 
ATOM   4807 C CA  . LEU C 3 406 ? 198.740 205.131 176.635 1.00 64.61 ? 406 LEU A CA  1 
ATOM   4808 C C   . LEU C 3 406 ? 197.567 205.116 175.665 1.00 64.61 ? 406 LEU A C   1 
ATOM   4809 O O   . LEU C 3 406 ? 197.335 206.080 174.930 1.00 64.61 ? 406 LEU A O   1 
ATOM   4810 C CB  . LEU C 3 406 ? 198.352 205.836 177.933 1.00 64.61 ? 406 LEU A CB  1 
ATOM   4811 C CG  . LEU C 3 406 ? 198.961 205.264 179.217 1.00 64.61 ? 406 LEU A CG  1 
ATOM   4812 C CD1 . LEU C 3 406 ? 198.214 204.010 179.630 1.00 64.61 ? 406 LEU A CD1 1 
ATOM   4813 C CD2 . LEU C 3 406 ? 200.437 204.958 179.058 1.00 64.61 ? 406 LEU A CD2 1 
ATOM   4814 N N   . LEU C 3 407 ? 196.823 204.014 175.675 1.00 80.55 ? 407 LEU A N   1 
ATOM   4815 C CA  . LEU C 3 407 ? 195.793 203.781 174.675 1.00 80.55 ? 407 LEU A CA  1 
ATOM   4816 C C   . LEU C 3 407 ? 194.671 204.807 174.788 1.00 80.55 ? 407 LEU A C   1 
ATOM   4817 O O   . LEU C 3 407 ? 194.408 205.364 175.857 1.00 80.55 ? 407 LEU A O   1 
ATOM   4818 C CB  . LEU C 3 407 ? 195.220 202.370 174.817 1.00 80.55 ? 407 LEU A CB  1 
ATOM   4819 C CG  . LEU C 3 407 ? 195.994 201.228 174.152 1.00 80.55 ? 407 LEU A CG  1 
ATOM   4820 C CD1 . LEU C 3 407 ? 197.180 200.798 175.003 1.00 80.55 ? 407 LEU A CD1 1 
ATOM   4821 C CD2 . LEU C 3 407 ? 195.073 200.048 173.879 1.00 80.55 ? 407 LEU A CD2 1 
ATOM   4822 N N   . ARG C 3 408 ? 194.013 205.056 173.659 1.00 90.73 ? 408 ARG A N   1 
ATOM   4823 C CA  . ARG C 3 408 ? 192.906 206.000 173.623 1.00 90.73 ? 408 ARG A CA  1 
ATOM   4824 C C   . ARG C 3 408 ? 191.697 205.441 174.364 1.00 90.73 ? 408 ARG A C   1 
ATOM   4825 O O   . ARG C 3 408 ? 191.421 204.238 174.324 1.00 90.73 ? 408 ARG A O   1 
ATOM   4826 C CB  . ARG C 3 408 ? 192.533 206.321 172.176 1.00 90.73 ? 408 ARG A CB  1 
ATOM   4827 C CG  . ARG C 3 408 ? 192.132 205.102 171.358 1.00 90.73 ? 408 ARG A CG  1 
ATOM   4828 C CD  . ARG C 3 408 ? 192.467 205.276 169.887 1.00 90.73 ? 408 ARG A CD  1 
ATOM   4829 N NE  . ARG C 3 408 ? 192.016 204.140 169.092 1.00 90.73 ? 408 ARG A NE  1 
ATOM   4830 C CZ  . ARG C 3 408 ? 190.819 204.045 168.529 1.00 90.73 ? 408 ARG A CZ  1 
ATOM   4831 N NH1 . ARG C 3 408 ? 189.919 205.007 168.653 1.00 90.73 ? 408 ARG A NH1 1 
ATOM   4832 N NH2 . ARG C 3 408 ? 190.518 202.959 167.824 1.00 90.73 ? 408 ARG A NH2 1 
ATOM   4833 N N   . GLU C 3 409 ? 190.981 206.322 175.052 1.00 92.58 ? 409 GLU A N   1 
ATOM   4834 C CA  . GLU C 3 409 ? 189.747 205.951 175.744 1.00 92.58 ? 409 GLU A CA  1 
ATOM   4835 C C   . GLU C 3 409 ? 188.533 206.295 174.882 1.00 92.58 ? 409 GLU A C   1 
ATOM   4836 O O   . GLU C 3 409 ? 187.698 207.130 175.229 1.00 92.58 ? 409 GLU A O   1 
ATOM   4837 C CB  . GLU C 3 409 ? 189.679 206.636 177.105 1.00 92.58 ? 409 GLU A CB  1 
ATOM   4838 C CG  . GLU C 3 409 ? 190.783 206.220 178.063 1.00 92.58 ? 409 GLU A CG  1 
ATOM   4839 C CD  . GLU C 3 409 ? 190.761 204.736 178.372 1.00 92.58 ? 409 GLU A CD  1 
ATOM   4840 O OE1 . GLU C 3 409 ? 189.656 204.161 178.462 1.00 92.58 ? 409 GLU A OE1 1 
ATOM   4841 O OE2 . GLU C 3 409 ? 191.849 204.144 178.525 1.00 92.58 ? 409 GLU A OE2 1 
ATOM   4842 N N   . GLY C 3 410 ? 188.448 205.628 173.735 1.00 92.70 ? 410 GLY A N   1 
ATOM   4843 C CA  . GLY C 3 410 ? 187.384 205.868 172.787 1.00 92.70 ? 410 GLY A CA  1 
ATOM   4844 C C   . GLY C 3 410 ? 187.627 207.007 171.822 1.00 92.70 ? 410 GLY A C   1 
ATOM   4845 O O   . GLY C 3 410 ? 186.785 207.243 170.945 1.00 92.70 ? 410 GLY A O   1 
ATOM   4846 N N   . ALA C 3 411 ? 188.743 207.720 171.951 1.00 92.20 ? 411 ALA A N   1 
ATOM   4847 C CA  . ALA C 3 411 ? 189.053 208.806 171.037 1.00 92.20 ? 411 ALA A CA  1 
ATOM   4848 C C   . ALA C 3 411 ? 189.435 208.261 169.664 1.00 92.20 ? 411 ALA A C   1 
ATOM   4849 O O   . ALA C 3 411 ? 189.845 207.107 169.513 1.00 92.20 ? 411 ALA A O   1 
ATOM   4850 C CB  . ALA C 3 411 ? 190.186 209.669 171.592 1.00 92.20 ? 411 ALA A CB  1 
ATOM   4851 N N   . ASN C 3 412 ? 189.287 209.110 168.651 1.00 91.41 ? 412 ASN A N   1 
ATOM   4852 C CA  . ASN C 3 412 ? 189.625 208.715 167.290 1.00 91.41 ? 412 ASN A CA  1 
ATOM   4853 C C   . ASN C 3 412 ? 191.134 208.575 167.142 1.00 91.41 ? 412 ASN A C   1 
ATOM   4854 O O   . ASN C 3 412 ? 191.896 209.446 167.573 1.00 91.41 ? 412 ASN A O   1 
ATOM   4855 C CB  . ASN C 3 412 ? 189.086 209.737 166.292 1.00 91.41 ? 412 ASN A CB  1 
ATOM   4856 C CG  . ASN C 3 412 ? 189.047 209.202 164.874 1.00 91.41 ? 412 ASN A CG  1 
ATOM   4857 O OD1 . ASN C 3 412 ? 189.383 208.044 164.626 1.00 91.41 ? 412 ASN A OD1 1 
ATOM   4858 N ND2 . ASN C 3 412 ? 188.634 210.044 163.935 1.00 91.41 ? 412 ASN A ND2 1 
ATOM   4859 N N   . ARG C 3 413 ? 191.567 207.472 166.529 1.00 88.02 ? 413 ARG A N   1 
ATOM   4860 C CA  . ARG C 3 413 ? 192.989 207.230 166.324 1.00 88.02 ? 413 ARG A CA  1 
ATOM   4861 C C   . ARG C 3 413 ? 193.538 207.957 165.102 1.00 88.02 ? 413 ARG A C   1 
ATOM   4862 O O   . ARG C 3 413 ? 194.760 208.044 164.946 1.00 88.02 ? 413 ARG A O   1 
ATOM   4863 C CB  . ARG C 3 413 ? 193.249 205.726 166.194 1.00 88.02 ? 413 ARG A CB  1 
ATOM   4864 C CG  . ARG C 3 413 ? 194.694 205.312 166.436 1.00 88.02 ? 413 ARG A CG  1 
ATOM   4865 C CD  . ARG C 3 413 ? 194.909 203.839 166.126 1.00 88.02 ? 413 ARG A CD  1 
ATOM   4866 N NE  . ARG C 3 413 ? 196.284 203.424 166.379 1.00 88.02 ? 413 ARG A NE  1 
ATOM   4867 C CZ  . ARG C 3 413 ? 196.700 202.853 167.501 1.00 88.02 ? 413 ARG A CZ  1 
ATOM   4868 N NH1 . ARG C 3 413 ? 195.870 202.610 168.502 1.00 88.02 ? 413 ARG A NH1 1 
ATOM   4869 N NH2 . ARG C 3 413 ? 197.981 202.516 167.621 1.00 88.02 ? 413 ARG A NH2 1 
ATOM   4870 N N   . GLU C 3 414 ? 192.667 208.489 164.243 1.00 89.65 ? 414 GLU A N   1 
ATOM   4871 C CA  . GLU C 3 414 ? 193.122 209.106 163.002 1.00 89.65 ? 414 GLU A CA  1 
ATOM   4872 C C   . GLU C 3 414 ? 193.798 210.455 163.225 1.00 89.65 ? 414 GLU A C   1 
ATOM   4873 O O   . GLU C 3 414 ? 194.577 210.889 162.370 1.00 89.65 ? 414 GLU A O   1 
ATOM   4874 C CB  . GLU C 3 414 ? 191.943 209.267 162.040 1.00 89.65 ? 414 GLU A CB  1 
ATOM   4875 C CG  . GLU C 3 414 ? 192.340 209.489 160.589 1.00 89.65 ? 414 GLU A CG  1 
ATOM   4876 C CD  . GLU C 3 414 ? 191.146 209.500 159.654 1.00 89.65 ? 414 GLU A CD  1 
ATOM   4877 O OE1 . GLU C 3 414 ? 190.020 209.759 160.128 1.00 89.65 ? 414 GLU A OE1 1 
ATOM   4878 O OE2 . GLU C 3 414 ? 191.334 209.250 158.445 1.00 89.65 ? 414 GLU A OE2 1 
ATOM   4879 N N   . ILE C 3 415 ? 193.529 211.122 164.345 1.00 87.32 ? 415 ILE A N   1 
ATOM   4880 C CA  . ILE C 3 415 ? 194.044 212.462 164.592 1.00 87.32 ? 415 ILE A CA  1 
ATOM   4881 C C   . ILE C 3 415 ? 194.911 212.513 165.849 1.00 87.32 ? 415 ILE A C   1 
ATOM   4882 O O   . ILE C 3 415 ? 195.117 213.580 166.415 1.00 87.32 ? 415 ILE A O   1 
ATOM   4883 C CB  . ILE C 3 415 ? 192.897 213.488 164.668 1.00 87.32 ? 415 ILE A CB  1 
ATOM   4884 C CG1 . ILE C 3 415 ? 191.971 213.167 165.843 1.00 87.32 ? 415 ILE A CG1 1 
ATOM   4885 C CG2 . ILE C 3 415 ? 192.118 213.519 163.361 1.00 87.32 ? 415 ILE A CG2 1 
ATOM   4886 C CD1 . ILE C 3 415 ? 190.914 214.219 166.094 1.00 87.32 ? 415 ILE A CD1 1 
ATOM   4887 N N   . LEU C 3 416 ? 195.425 211.367 166.293 1.00 80.96 ? 416 LEU A N   1 
ATOM   4888 C CA  . LEU C 3 416 ? 196.206 211.342 167.526 1.00 80.96 ? 416 LEU A CA  1 
ATOM   4889 C C   . LEU C 3 416 ? 197.547 212.048 167.356 1.00 80.96 ? 416 LEU A C   1 
ATOM   4890 O O   . LEU C 3 416 ? 197.920 212.896 168.175 1.00 80.96 ? 416 LEU A O   1 
ATOM   4891 C CB  . LEU C 3 416 ? 196.412 209.899 167.987 1.00 80.96 ? 416 LEU A CB  1 
ATOM   4892 C CG  . LEU C 3 416 ? 195.172 209.183 168.523 1.00 80.96 ? 416 LEU A CG  1 
ATOM   4893 C CD1 . LEU C 3 416 ? 195.539 207.817 169.080 1.00 80.96 ? 416 LEU A CD1 1 
ATOM   4894 C CD2 . LEU C 3 416 ? 194.482 210.029 169.582 1.00 80.96 ? 416 LEU A CD2 1 
ATOM   4895 N N   . GLY C 3 417 ? 198.281 211.725 166.296 1.00 72.98 ? 417 GLY A N   1 
ATOM   4896 C CA  . GLY C 3 417 ? 199.630 212.237 166.161 1.00 72.98 ? 417 GLY A CA  1 
ATOM   4897 C C   . GLY C 3 417 ? 200.663 211.136 166.027 1.00 72.98 ? 417 GLY A C   1 
ATOM   4898 O O   . GLY C 3 417 ? 200.724 210.465 164.994 1.00 72.98 ? 417 GLY A O   1 
ATOM   4899 N N   . ILE C 3 418 ? 201.493 210.947 167.049 1.00 62.31 ? 418 ILE A N   1 
ATOM   4900 C CA  . ILE C 3 418 ? 202.501 209.894 167.055 1.00 62.31 ? 418 ILE A CA  1 
ATOM   4901 C C   . ILE C 3 418 ? 202.202 208.948 168.207 1.00 62.31 ? 418 ILE A C   1 
ATOM   4902 O O   . ILE C 3 418 ? 202.265 209.346 169.376 1.00 62.31 ? 418 ILE A O   1 
ATOM   4903 C CB  . ILE C 3 418 ? 203.919 210.466 167.175 1.00 62.31 ? 418 ILE A CB  1 
ATOM   4904 C CG1 . ILE C 3 418 ? 204.199 211.439 166.033 1.00 62.31 ? 418 ILE A CG1 1 
ATOM   4905 C CG2 . ILE C 3 418 ? 204.934 209.349 167.152 1.00 62.31 ? 418 ILE A CG2 1 
ATOM   4906 C CD1 . ILE C 3 418 ? 205.652 211.834 165.917 1.00 62.31 ? 418 ILE A CD1 1 
ATOM   4907 N N   . ILE C 3 419 ? 201.904 207.694 167.885 1.00 60.99 ? 419 ILE A N   1 
ATOM   4908 C CA  . ILE C 3 419 ? 201.677 206.652 168.880 1.00 60.99 ? 419 ILE A CA  1 
ATOM   4909 C C   . ILE C 3 419 ? 202.871 205.711 168.834 1.00 60.99 ? 419 ILE A C   1 
ATOM   4910 O O   . ILE C 3 419 ? 203.115 205.062 167.811 1.00 60.99 ? 419 ILE A O   1 
ATOM   4911 C CB  . ILE C 3 419 ? 200.376 205.880 168.620 1.00 60.99 ? 419 ILE A CB  1 
ATOM   4912 C CG1 . ILE C 3 419 ? 199.152 206.793 168.700 1.00 60.99 ? 419 ILE A CG1 1 
ATOM   4913 C CG2 . ILE C 3 419 ? 200.234 204.745 169.618 1.00 60.99 ? 419 ILE A CG2 1 
ATOM   4914 C CD1 . ILE C 3 419 ? 199.240 207.872 169.731 1.00 60.99 ? 419 ILE A CD1 1 
ATOM   4915 N N   . VAL C 3 420 ? 203.607 205.621 169.938 1.00 52.34 ? 420 VAL A N   1 
ATOM   4916 C CA  . VAL C 3 420 ? 204.805 204.793 170.011 1.00 52.34 ? 420 VAL A CA  1 
ATOM   4917 C C   . VAL C 3 420 ? 204.562 203.654 170.993 1.00 52.34 ? 420 VAL A C   1 
ATOM   4918 O O   . VAL C 3 420 ? 203.950 203.850 172.051 1.00 52.34 ? 420 VAL A O   1 
ATOM   4919 C CB  . VAL C 3 420 ? 206.044 205.622 170.388 1.00 52.34 ? 420 VAL A CB  1 
ATOM   4920 C CG1 . VAL C 3 420 ? 206.082 206.889 169.578 1.00 52.34 ? 420 VAL A CG1 1 
ATOM   4921 C CG2 . VAL C 3 420 ? 206.059 205.952 171.856 1.00 52.34 ? 420 VAL A CG2 1 
ATOM   4922 N N   . SER C 3 421 ? 204.993 202.453 170.613 1.00 46.62 ? 421 SER A N   1 
ATOM   4923 C CA  . SER C 3 421 ? 204.856 201.262 171.436 1.00 46.62 ? 421 SER A CA  1 
ATOM   4924 C C   . SER C 3 421 ? 206.098 200.406 171.260 1.00 46.62 ? 421 SER A C   1 
ATOM   4925 O O   . SER C 3 421 ? 206.871 200.592 170.319 1.00 46.62 ? 421 SER A O   1 
ATOM   4926 C CB  . SER C 3 421 ? 203.604 200.459 171.077 1.00 46.62 ? 421 SER A CB  1 
ATOM   4927 O OG  . SER C 3 421 ? 203.688 199.966 169.753 1.00 46.62 ? 421 SER A OG  1 
ATOM   4928 N N   . TYR C 3 422 ? 206.282 199.452 172.168 1.00 44.92 ? 422 TYR A N   1 
ATOM   4929 C CA  . TYR C 3 422 ? 207.490 198.641 172.200 1.00 44.92 ? 422 TYR A CA  1 
ATOM   4930 C C   . TYR C 3 422 ? 207.146 197.159 172.228 1.00 44.92 ? 422 TYR A C   1 
ATOM   4931 O O   . TYR C 3 422 ? 206.199 196.746 172.902 1.00 44.92 ? 422 TYR A O   1 
ATOM   4932 C CB  . TYR C 3 422 ? 208.347 198.989 173.409 1.00 44.92 ? 422 TYR A CB  1 
ATOM   4933 C CG  . TYR C 3 422 ? 208.969 200.358 173.339 1.00 44.92 ? 422 TYR A CG  1 
ATOM   4934 C CD1 . TYR C 3 422 ? 210.125 200.574 172.615 1.00 44.92 ? 422 TYR A CD1 1 
ATOM   4935 C CD2 . TYR C 3 422 ? 208.408 201.432 174.005 1.00 44.92 ? 422 TYR A CD2 1 
ATOM   4936 C CE1 . TYR C 3 422 ? 210.697 201.811 172.548 1.00 44.92 ? 422 TYR A CE1 1 
ATOM   4937 C CE2 . TYR C 3 422 ? 208.979 202.678 173.942 1.00 44.92 ? 422 TYR A CE2 1 
ATOM   4938 C CZ  . TYR C 3 422 ? 210.124 202.858 173.208 1.00 44.92 ? 422 TYR A CZ  1 
ATOM   4939 O OH  . TYR C 3 422 ? 210.705 204.100 173.137 1.00 44.92 ? 422 TYR A OH  1 
ATOM   4940 N N   . LYS C 3 423 ? 207.927 196.363 171.500 1.00 42.07 ? 423 LYS A N   1 
ATOM   4941 C CA  . LYS C 3 423 ? 207.774 194.918 171.477 1.00 42.07 ? 423 LYS A CA  1 
ATOM   4942 C C   . LYS C 3 423 ? 209.139 194.255 171.606 1.00 42.07 ? 423 LYS A C   1 
ATOM   4943 O O   . LYS C 3 423 ? 210.169 194.839 171.267 1.00 42.07 ? 423 LYS A O   1 
ATOM   4944 C CB  . LYS C 3 423 ? 207.085 194.442 170.197 1.00 42.07 ? 423 LYS A CB  1 
ATOM   4945 C CG  . LYS C 3 423 ? 205.664 194.918 170.036 1.00 42.07 ? 423 LYS A CG  1 
ATOM   4946 C CD  . LYS C 3 423 ? 204.943 194.093 168.990 1.00 42.07 ? 423 LYS A CD  1 
ATOM   4947 C CE  . LYS C 3 423 ? 203.560 194.643 168.710 1.00 42.07 ? 423 LYS A CE  1 
ATOM   4948 N NZ  . LYS C 3 423 ? 202.774 193.730 167.839 1.00 42.07 ? 423 LYS A NZ  1 
ATOM   4949 N N   . VAL C 3 424 ? 209.135 193.018 172.104 1.00 41.49 ? 424 VAL A N   1 
ATOM   4950 C CA  . VAL C 3 424 ? 210.345 192.229 172.316 1.00 41.49 ? 424 VAL A CA  1 
ATOM   4951 C C   . VAL C 3 424 ? 210.244 190.946 171.502 1.00 41.49 ? 424 VAL A C   1 
ATOM   4952 O O   . VAL C 3 424 ? 209.189 190.308 171.470 1.00 41.49 ? 424 VAL A O   1 
ATOM   4953 C CB  . VAL C 3 424 ? 210.560 191.910 173.809 1.00 41.49 ? 424 VAL A CB  1 
ATOM   4954 C CG1 . VAL C 3 424 ? 211.508 190.745 173.974 1.00 41.49 ? 424 VAL A CG1 1 
ATOM   4955 C CG2 . VAL C 3 424 ? 211.101 193.112 174.531 1.00 41.49 ? 424 VAL A CG2 1 
ATOM   4956 N N   . LYS C 3 425 ? 211.340 190.567 170.845 1.00 41.45 ? 425 LYS A N   1 
ATOM   4957 C CA  . LYS C 3 425 ? 211.341 189.434 169.927 1.00 41.45 ? 425 LYS A CA  1 
ATOM   4958 C C   . LYS C 3 425 ? 212.439 188.449 170.291 1.00 41.45 ? 425 LYS A C   1 
ATOM   4959 O O   . LYS C 3 425 ? 213.583 188.848 170.527 1.00 41.45 ? 425 LYS A O   1 
ATOM   4960 C CB  . LYS C 3 425 ? 211.519 189.913 168.489 1.00 41.45 ? 425 LYS A CB  1 
ATOM   4961 C CG  . LYS C 3 425 ? 211.507 188.821 167.456 1.00 41.45 ? 425 LYS A CG  1 
ATOM   4962 C CD  . LYS C 3 425 ? 211.523 189.411 166.062 1.00 41.45 ? 425 LYS A CD  1 
ATOM   4963 C CE  . LYS C 3 425 ? 211.004 188.429 165.032 1.00 41.45 ? 425 LYS A CE  1 
ATOM   4964 N NZ  . LYS C 3 425 ? 210.155 189.098 164.009 1.00 41.45 ? 425 LYS A NZ  1 
ATOM   4965 N N   . VAL C 3 426 ? 212.092 187.165 170.328 1.00 40.73 ? 426 VAL A N   1 
ATOM   4966 C CA  . VAL C 3 426 ? 213.040 186.084 170.578 1.00 40.73 ? 426 VAL A CA  1 
ATOM   4967 C C   . VAL C 3 426 ? 212.986 185.140 169.390 1.00 40.73 ? 426 VAL A C   1 
ATOM   4968 O O   . VAL C 3 426 ? 211.966 184.481 169.168 1.00 40.73 ? 426 VAL A O   1 
ATOM   4969 C CB  . VAL C 3 426 ? 212.727 185.329 171.877 1.00 40.73 ? 426 VAL A CB  1 
ATOM   4970 C CG1 . VAL C 3 426 ? 213.618 184.118 172.006 1.00 40.73 ? 426 VAL A CG1 1 
ATOM   4971 C CG2 . VAL C 3 426 ? 212.888 186.235 173.071 1.00 40.73 ? 426 VAL A CG2 1 
ATOM   4972 N N   . LYS C 3 427 ? 214.088 185.042 168.653 1.00 44.07 ? 427 LYS A N   1 
ATOM   4973 C CA  . LYS C 3 427 ? 214.140 184.257 167.427 1.00 44.07 ? 427 LYS A CA  1 
ATOM   4974 C C   . LYS C 3 427 ? 215.224 183.196 167.513 1.00 44.07 ? 427 LYS A C   1 
ATOM   4975 O O   . LYS C 3 427 ? 216.340 183.467 167.964 1.00 44.07 ? 427 LYS A O   1 
ATOM   4976 C CB  . LYS C 3 427 ? 214.397 185.153 166.215 1.00 44.07 ? 427 LYS A CB  1 
ATOM   4977 C CG  . LYS C 3 427 ? 214.215 184.457 164.879 1.00 44.07 ? 427 LYS A CG  1 
ATOM   4978 C CD  . LYS C 3 427 ? 214.357 185.427 163.715 1.00 44.07 ? 427 LYS A CD  1 
ATOM   4979 C CE  . LYS C 3 427 ? 215.408 186.491 163.995 1.00 44.07 ? 427 LYS A CE  1 
ATOM   4980 N NZ  . LYS C 3 427 ? 215.657 187.348 162.807 1.00 44.07 ? 427 LYS A NZ  1 
ATOM   4981 N N   . LEU C 3 428 ? 214.891 181.992 167.068 1.00 46.17 ? 428 LEU A N   1 
ATOM   4982 C CA  . LEU C 3 428 ? 215.831 180.888 166.997 1.00 46.17 ? 428 LEU A CA  1 
ATOM   4983 C C   . LEU C 3 428 ? 216.317 180.708 165.566 1.00 46.17 ? 428 LEU A C   1 
ATOM   4984 O O   . LEU C 3 428 ? 215.608 181.020 164.607 1.00 46.17 ? 428 LEU A O   1 
ATOM   4985 C CB  . LEU C 3 428 ? 215.191 179.592 167.486 1.00 46.17 ? 428 LEU A CB  1 
ATOM   4986 C CG  . LEU C 3 428 ? 214.272 179.712 168.694 1.00 46.17 ? 428 LEU A CG  1 
ATOM   4987 C CD1 . LEU C 3 428 ? 213.675 178.366 169.033 1.00 46.17 ? 428 LEU A CD1 1 
ATOM   4988 C CD2 . LEU C 3 428 ? 215.026 180.268 169.880 1.00 46.17 ? 428 LEU A CD2 1 
ATOM   4989 N N   . VAL C 3 429 ? 217.538 180.202 165.430 1.00 51.53 ? 429 VAL A N   1 
ATOM   4990 C CA  . VAL C 3 429 ? 218.158 179.946 164.136 1.00 51.53 ? 429 VAL A CA  1 
ATOM   4991 C C   . VAL C 3 429 ? 218.470 178.461 164.047 1.00 51.53 ? 429 VAL A C   1 
ATOM   4992 O O   . VAL C 3 429 ? 219.055 177.888 164.974 1.00 51.53 ? 429 VAL A O   1 
ATOM   4993 C CB  . VAL C 3 429 ? 219.426 180.791 163.944 1.00 51.53 ? 429 VAL A CB  1 
ATOM   4994 C CG1 . VAL C 3 429 ? 219.856 180.776 162.488 1.00 51.53 ? 429 VAL A CG1 1 
ATOM   4995 C CG2 . VAL C 3 429 ? 219.187 182.208 164.421 1.00 51.53 ? 429 VAL A CG2 1 
ATOM   4996 N N   . VAL C 3 430 ? 218.083 177.838 162.939 1.00 59.63 ? 430 VAL A N   1 
ATOM   4997 C CA  . VAL C 3 430 ? 218.138 176.389 162.785 1.00 59.63 ? 430 VAL A CA  1 
ATOM   4998 C C   . VAL C 3 430 ? 218.955 176.043 161.548 1.00 59.63 ? 430 VAL A C   1 
ATOM   4999 O O   . VAL C 3 430 ? 218.789 176.660 160.490 1.00 59.63 ? 430 VAL A O   1 
ATOM   5000 C CB  . VAL C 3 430 ? 216.719 175.789 162.699 1.00 59.63 ? 430 VAL A CB  1 
ATOM   5001 C CG1 . VAL C 3 430 ? 216.724 174.491 161.921 1.00 59.63 ? 430 VAL A CG1 1 
ATOM   5002 C CG2 . VAL C 3 430 ? 216.155 175.573 164.089 1.00 59.63 ? 430 VAL A CG2 1 
ATOM   5003 N N   . SER C 3 431 ? 219.840 175.055 161.686 1.00 68.34 ? 431 SER A N   1 
ATOM   5004 C CA  . SER C 3 431 ? 220.713 174.623 160.605 1.00 68.34 ? 431 SER A CA  1 
ATOM   5005 C C   . SER C 3 431 ? 219.941 173.811 159.566 1.00 68.34 ? 431 SER A C   1 
ATOM   5006 O O   . SER C 3 431 ? 218.813 173.368 159.792 1.00 68.34 ? 431 SER A O   1 
ATOM   5007 C CB  . SER C 3 431 ? 221.874 173.800 161.154 1.00 68.34 ? 431 SER A CB  1 
ATOM   5008 O OG  . SER C 3 431 ? 222.783 173.455 160.125 1.00 68.34 ? 431 SER A OG  1 
ATOM   5009 N N   . ARG C 3 432 ? 220.580 173.615 158.411 1.00 79.90 ? 432 ARG A N   1 
ATOM   5010 C CA  . ARG C 3 432 ? 220.003 172.893 157.276 1.00 79.90 ? 432 ARG A CA  1 
ATOM   5011 C C   . ARG C 3 432 ? 218.693 173.541 156.822 1.00 79.90 ? 432 ARG A C   1 
ATOM   5012 O O   . ARG C 3 432 ? 217.620 172.936 156.854 1.00 79.90 ? 432 ARG A O   1 
ATOM   5013 C CB  . ARG C 3 432 ? 219.802 171.411 157.609 1.00 79.90 ? 432 ARG A CB  1 
ATOM   5014 C CG  . ARG C 3 432 ? 221.057 170.572 157.463 1.00 79.90 ? 432 ARG A CG  1 
ATOM   5015 C CD  . ARG C 3 432 ? 220.762 169.095 157.645 1.00 79.90 ? 432 ARG A CD  1 
ATOM   5016 N NE  . ARG C 3 432 ? 221.932 168.270 157.370 1.00 79.90 ? 432 ARG A NE  1 
ATOM   5017 C CZ  . ARG C 3 432 ? 222.897 168.027 158.246 1.00 79.90 ? 432 ARG A CZ  1 
ATOM   5018 N NH1 . ARG C 3 432 ? 222.865 168.529 159.469 1.00 79.90 ? 432 ARG A NH1 1 
ATOM   5019 N NH2 . ARG C 3 432 ? 223.922 167.260 157.885 1.00 79.90 ? 432 ARG A NH2 1 
ATOM   5020 N N   . GLY C 3 433 ? 218.804 174.794 156.390 1.00 85.10 ? 433 GLY A N   1 
ATOM   5021 C CA  . GLY C 3 433 ? 217.653 175.547 155.940 1.00 85.10 ? 433 GLY A CA  1 
ATOM   5022 C C   . GLY C 3 433 ? 217.219 175.299 154.515 1.00 85.10 ? 433 GLY A C   1 
ATOM   5023 O O   . GLY C 3 433 ? 216.205 175.854 154.083 1.00 85.10 ? 433 GLY A O   1 
ATOM   5024 N N   . SER C 3 442 ? 211.652 180.450 156.817 1.00 66.72 ? 442 SER A N   1 
ATOM   5025 C CA  . SER C 3 442 ? 211.666 181.460 157.861 1.00 66.72 ? 442 SER A CA  1 
ATOM   5026 C C   . SER C 3 442 ? 211.954 180.800 159.201 1.00 66.72 ? 442 SER A C   1 
ATOM   5027 O O   . SER C 3 442 ? 211.765 179.594 159.380 1.00 66.72 ? 442 SER A O   1 
ATOM   5028 C CB  . SER C 3 442 ? 210.336 182.221 157.922 1.00 66.72 ? 442 SER A CB  1 
ATOM   5029 O OG  . SER C 3 442 ? 209.921 182.623 156.629 1.00 66.72 ? 442 SER A OG  1 
ATOM   5030 N N   . ASP C 3 443 ? 212.414 181.612 160.147 1.00 59.95 ? 443 ASP A N   1 
ATOM   5031 C CA  . ASP C 3 443 ? 212.759 181.139 161.477 1.00 59.95 ? 443 ASP A CA  1 
ATOM   5032 C C   . ASP C 3 443 ? 211.507 181.094 162.351 1.00 59.95 ? 443 ASP A C   1 
ATOM   5033 O O   . ASP C 3 443 ? 210.379 181.213 161.868 1.00 59.95 ? 443 ASP A O   1 
ATOM   5034 C CB  . ASP C 3 443 ? 213.846 182.024 162.083 1.00 59.95 ? 443 ASP A CB  1 
ATOM   5035 C CG  . ASP C 3 443 ? 215.008 182.252 161.136 1.00 59.95 ? 443 ASP A CG  1 
ATOM   5036 O OD1 . ASP C 3 443 ? 215.334 181.329 160.360 1.00 59.95 ? 443 ASP A OD1 1 
ATOM   5037 O OD2 . ASP C 3 443 ? 215.596 183.353 161.168 1.00 59.95 ? 443 ASP A OD2 1 
ATOM   5038 N N   . VAL C 3 444 ? 211.698 180.914 163.653 1.00 49.11 ? 444 VAL A N   1 
ATOM   5039 C CA  . VAL C 3 444 ? 210.613 180.882 164.623 1.00 49.11 ? 444 VAL A CA  1 
ATOM   5040 C C   . VAL C 3 444 ? 210.887 181.943 165.677 1.00 49.11 ? 444 VAL A C   1 
ATOM   5041 O O   . VAL C 3 444 ? 212.001 182.028 166.205 1.00 49.11 ? 444 VAL A O   1 
ATOM   5042 C CB  . VAL C 3 444 ? 210.467 179.489 165.258 1.00 49.11 ? 444 VAL A CB  1 
ATOM   5043 C CG1 . VAL C 3 444 ? 211.811 178.980 165.743 1.00 49.11 ? 444 VAL A CG1 1 
ATOM   5044 C CG2 . VAL C 3 444 ? 209.481 179.535 166.400 1.00 49.11 ? 444 VAL A CG2 1 
ATOM   5045 N N   . ALA C 3 445 ? 209.880 182.763 165.968 1.00 44.78 ? 445 ALA A N   1 
ATOM   5046 C CA  . ALA C 3 445 ? 210.051 183.859 166.908 1.00 44.78 ? 445 ALA A CA  1 
ATOM   5047 C C   . ALA C 3 445 ? 208.710 184.226 167.519 1.00 44.78 ? 445 ALA A C   1 
ATOM   5048 O O   . ALA C 3 445 ? 207.652 183.859 167.005 1.00 44.78 ? 445 ALA A O   1 
ATOM   5049 C CB  . ALA C 3 445 ? 210.680 185.082 166.235 1.00 44.78 ? 445 ALA A CB  1 
ATOM   5050 N N   . VAL C 3 446 ? 208.768 184.955 168.636 1.00 42.92 ? 446 VAL A N   1 
ATOM   5051 C CA  . VAL C 3 446 ? 207.586 185.380 169.373 1.00 42.92 ? 446 VAL A CA  1 
ATOM   5052 C C   . VAL C 3 446 ? 207.727 186.850 169.746 1.00 42.92 ? 446 VAL A C   1 
ATOM   5053 O O   . VAL C 3 446 ? 208.827 187.403 169.790 1.00 42.92 ? 446 VAL A O   1 
ATOM   5054 C CB  . VAL C 3 446 ? 207.354 184.534 170.640 1.00 42.92 ? 446 VAL A CB  1 
ATOM   5055 C CG1 . VAL C 3 446 ? 207.360 183.072 170.309 1.00 42.92 ? 446 VAL A CG1 1 
ATOM   5056 C CG2 . VAL C 3 446 ? 208.409 184.839 171.680 1.00 42.92 ? 446 VAL A CG2 1 
ATOM   5057 N N   . GLU C 3 447 ? 206.590 187.476 170.033 1.00 43.75 ? 447 GLU A N   1 
ATOM   5058 C CA  . GLU C 3 447 ? 206.518 188.878 170.412 1.00 43.75 ? 447 GLU A CA  1 
ATOM   5059 C C   . GLU C 3 447 ? 205.977 188.996 171.829 1.00 43.75 ? 447 GLU A C   1 
ATOM   5060 O O   . GLU C 3 447 ? 205.103 188.227 172.234 1.00 43.75 ? 447 GLU A O   1 
ATOM   5061 C CB  . GLU C 3 447 ? 205.618 189.671 169.453 1.00 43.75 ? 447 GLU A CB  1 
ATOM   5062 C CG  . GLU C 3 447 ? 205.878 189.568 167.929 1.00 43.75 ? 447 GLU A CG  1 
ATOM   5063 C CD  . GLU C 3 447 ? 207.340 189.482 167.471 1.00 43.75 ? 447 GLU A CD  1 
ATOM   5064 O OE1 . GLU C 3 447 ? 207.543 189.386 166.242 1.00 43.75 ? 447 GLU A OE1 1 
ATOM   5065 O OE2 . GLU C 3 447 ? 208.286 189.586 168.277 1.00 43.75 ? 447 GLU A OE2 1 
ATOM   5066 N N   . LEU C 3 448 ? 206.498 189.962 172.579 1.00 41.84 ? 448 LEU A N   1 
ATOM   5067 C CA  . LEU C 3 448 ? 206.075 190.198 173.958 1.00 41.84 ? 448 LEU A CA  1 
ATOM   5068 C C   . LEU C 3 448 ? 205.951 191.696 174.182 1.00 41.84 ? 448 LEU A C   1 
ATOM   5069 O O   . LEU C 3 448 ? 206.934 192.373 174.506 1.00 41.84 ? 448 LEU A O   1 
ATOM   5070 C CB  . LEU C 3 448 ? 207.060 189.582 174.950 1.00 41.84 ? 448 LEU A CB  1 
ATOM   5071 C CG  . LEU C 3 448 ? 207.360 188.095 174.808 1.00 41.84 ? 448 LEU A CG  1 
ATOM   5072 C CD1 . LEU C 3 448 ? 208.579 187.740 175.632 1.00 41.84 ? 448 LEU A CD1 1 
ATOM   5073 C CD2 . LEU C 3 448 ? 206.168 187.280 175.251 1.00 41.84 ? 448 LEU A CD2 1 
ATOM   5074 N N   . PRO C 3 449 ? 204.755 192.254 174.004 1.00 41.72 ? 449 PRO A N   1 
ATOM   5075 C CA  . PRO C 3 449 ? 204.584 193.700 174.184 1.00 41.72 ? 449 PRO A CA  1 
ATOM   5076 C C   . PRO C 3 449 ? 204.869 194.128 175.614 1.00 41.72 ? 449 PRO A C   1 
ATOM   5077 O O   . PRO C 3 449 ? 204.581 193.406 176.570 1.00 41.72 ? 449 PRO A O   1 
ATOM   5078 C CB  . PRO C 3 449 ? 203.114 193.931 173.820 1.00 41.72 ? 449 PRO A CB  1 
ATOM   5079 C CG  . PRO C 3 449 ? 202.745 192.759 172.974 1.00 41.72 ? 449 PRO A CG  1 
ATOM   5080 C CD  . PRO C 3 449 ? 203.534 191.608 173.506 1.00 41.72 ? 449 PRO A CD  1 
ATOM   5081 N N   . PHE C 3 450 ? 205.443 195.321 175.756 1.00 43.69 ? 450 PHE A N   1 
ATOM   5082 C CA  . PHE C 3 450 ? 205.737 195.861 177.075 1.00 43.69 ? 450 PHE A CA  1 
ATOM   5083 C C   . PHE C 3 450 ? 205.620 197.378 177.040 1.00 43.69 ? 450 PHE A C   1 
ATOM   5084 O O   . PHE C 3 450 ? 205.508 197.993 175.978 1.00 43.69 ? 450 PHE A O   1 
ATOM   5085 C CB  . PHE C 3 450 ? 207.115 195.413 177.580 1.00 43.69 ? 450 PHE A CB  1 
ATOM   5086 C CG  . PHE C 3 450 ? 208.273 196.140 176.959 1.00 43.69 ? 450 PHE A CG  1 
ATOM   5087 C CD1 . PHE C 3 450 ? 208.783 197.279 177.541 1.00 43.69 ? 450 PHE A CD1 1 
ATOM   5088 C CD2 . PHE C 3 450 ? 208.884 195.649 175.826 1.00 43.69 ? 450 PHE A CD2 1 
ATOM   5089 C CE1 . PHE C 3 450 ? 209.853 197.935 176.983 1.00 43.69 ? 450 PHE A CE1 1 
ATOM   5090 C CE2 . PHE C 3 450 ? 209.957 196.301 175.267 1.00 43.69 ? 450 PHE A CE2 1 
ATOM   5091 C CZ  . PHE C 3 450 ? 210.441 197.443 175.845 1.00 43.69 ? 450 PHE A CZ  1 
ATOM   5092 N N   . THR C 3 451 ? 205.636 197.974 178.230 1.00 47.39 ? 451 THR A N   1 
ATOM   5093 C CA  . THR C 3 451 ? 205.428 199.404 178.423 1.00 47.39 ? 451 THR A CA  1 
ATOM   5094 C C   . THR C 3 451 ? 206.707 200.036 178.958 1.00 47.39 ? 451 THR A C   1 
ATOM   5095 O O   . THR C 3 451 ? 207.230 199.604 179.989 1.00 47.39 ? 451 THR A O   1 
ATOM   5096 C CB  . THR C 3 451 ? 204.271 199.646 179.390 1.00 47.39 ? 451 THR A CB  1 
ATOM   5097 O OG1 . THR C 3 451 ? 203.053 199.158 178.815 1.00 47.39 ? 451 THR A OG1 1 
ATOM   5098 C CG2 . THR C 3 451 ? 204.131 201.111 179.712 1.00 47.39 ? 451 THR A CG2 1 
ATOM   5099 N N   . LEU C 3 452 ? 207.200 201.061 178.266 1.00 47.35 ? 452 LEU A N   1 
ATOM   5100 C CA  . LEU C 3 452 ? 208.404 201.787 178.662 1.00 47.35 ? 452 LEU A CA  1 
ATOM   5101 C C   . LEU C 3 452 ? 208.001 203.212 179.013 1.00 47.35 ? 452 LEU A C   1 
ATOM   5102 O O   . LEU C 3 452 ? 207.567 203.969 178.140 1.00 47.35 ? 452 LEU A O   1 
ATOM   5103 C CB  . LEU C 3 452 ? 209.444 201.766 177.547 1.00 47.35 ? 452 LEU A CB  1 
ATOM   5104 C CG  . LEU C 3 452 ? 210.907 201.866 177.971 1.00 47.35 ? 452 LEU A CG  1 
ATOM   5105 C CD1 . LEU C 3 452 ? 211.313 200.658 178.790 1.00 47.35 ? 452 LEU A CD1 1 
ATOM   5106 C CD2 . LEU C 3 452 ? 211.785 201.994 176.748 1.00 47.35 ? 452 LEU A CD2 1 
ATOM   5107 N N   . MET C 3 453 ? 208.128 203.586 180.291 1.00 52.02 ? 453 MET A N   1 
ATOM   5108 C CA  . MET C 3 453 ? 207.637 204.931 180.705 1.00 52.02 ? 453 MET A CA  1 
ATOM   5109 C C   . MET C 3 453 ? 208.555 205.566 181.755 1.00 52.02 ? 453 MET A C   1 
ATOM   5110 O O   . MET C 3 453 ? 209.624 204.989 182.037 1.00 52.02 ? 453 MET A O   1 
ATOM   5111 C CB  . MET C 3 453 ? 206.229 204.826 181.299 1.00 52.02 ? 453 MET A CB  1 
ATOM   5112 C CG  . MET C 3 453 ? 205.139 204.670 180.262 1.00 52.02 ? 453 MET A CG  1 
ATOM   5113 S SD  . MET C 3 453 ? 203.496 204.830 180.991 1.00 52.02 ? 453 MET A SD  1 
ATOM   5114 C CE  . MET C 3 453 ? 203.195 206.571 180.702 1.00 52.02 ? 453 MET A CE  1 
ATOM   5115 N N   . HIS C 3 454 ? 208.137 206.709 182.309 1.00 53.90 ? 454 HIS A N   1 
ATOM   5116 C CA  . HIS C 3 454 ? 208.936 207.419 183.345 1.00 53.90 ? 454 HIS A CA  1 
ATOM   5117 C C   . HIS C 3 454 ? 208.170 207.391 184.672 1.00 53.90 ? 454 HIS A C   1 
ATOM   5118 O O   . HIS C 3 454 ? 206.925 207.491 184.653 1.00 53.90 ? 454 HIS A O   1 
ATOM   5119 C CB  . HIS C 3 454 ? 209.193 208.866 182.916 1.00 53.90 ? 454 HIS A CB  1 
ATOM   5120 C CG  . HIS C 3 454 ? 210.386 209.056 182.040 1.00 53.90 ? 454 HIS A CG  1 
ATOM   5121 N ND1 . HIS C 3 454 ? 210.295 209.563 180.762 1.00 53.90 ? 454 HIS A ND1 1 
ATOM   5122 C CD2 . HIS C 3 454 ? 211.687 208.827 182.256 1.00 53.90 ? 454 HIS A CD2 1 
ATOM   5123 C CE1 . HIS C 3 454 ? 211.507 209.631 180.231 1.00 53.90 ? 454 HIS A CE1 1 
ATOM   5124 N NE2 . HIS C 3 454 ? 212.368 209.187 181.121 1.00 53.90 ? 454 HIS A NE2 1 
ATOM   5125 N N   . PRO C 3 455 ? 208.851 207.275 185.834 1.00 55.05 ? 455 PRO A N   1 
ATOM   5126 C CA  . PRO C 3 455 ? 208.165 207.178 187.127 1.00 55.05 ? 455 PRO A CA  1 
ATOM   5127 C C   . PRO C 3 455 ? 207.709 208.528 187.658 1.00 55.05 ? 455 PRO A C   1 
ATOM   5128 O O   . PRO C 3 455 ? 208.381 209.550 187.509 1.00 55.05 ? 455 PRO A O   1 
ATOM   5129 C CB  . PRO C 3 455 ? 209.241 206.567 188.032 1.00 55.05 ? 455 PRO A CB  1 
ATOM   5130 C CG  . PRO C 3 455 ? 210.521 207.063 187.459 1.00 55.05 ? 455 PRO A CG  1 
ATOM   5131 C CD  . PRO C 3 455 ? 210.316 207.230 185.975 1.00 55.05 ? 455 PRO A CD  1 
ATOM   5132 N N   . LYS C 3 456 ? 206.545 208.521 188.287 1.00 59.52 ? 456 LYS A N   1 
ATOM   5133 C CA  . LYS C 3 456 ? 205.997 209.737 188.874 1.00 59.52 ? 456 LYS A CA  1 
ATOM   5134 C C   . LYS C 3 456 ? 206.823 210.137 190.088 1.00 59.52 ? 456 LYS A C   1 
ATOM   5135 O O   . LYS C 3 456 ? 206.957 209.337 191.023 1.00 59.52 ? 456 LYS A O   1 
ATOM   5136 C CB  . LYS C 3 456 ? 204.542 209.523 189.270 1.00 59.52 ? 456 LYS A CB  1 
ATOM   5137 C CG  . LYS C 3 456 ? 203.841 210.778 189.760 1.00 59.52 ? 456 LYS A CG  1 
ATOM   5138 C CD  . LYS C 3 456 ? 202.494 210.448 190.382 1.00 59.52 ? 456 LYS A CD  1 
ATOM   5139 C CE  . LYS C 3 456 ? 201.544 209.850 189.356 1.00 59.52 ? 456 LYS A CE  1 
ATOM   5140 N NZ  . LYS C 3 456 ? 200.269 209.397 189.977 1.00 59.52 ? 456 LYS A NZ  1 
ATOM   5141 N N   . PRO C 3 457 ? 207.393 211.349 190.125 1.00 61.01 ? 457 PRO A N   1 
ATOM   5142 C CA  . PRO C 3 457 ? 208.223 211.792 191.249 1.00 61.01 ? 457 PRO A CA  1 
ATOM   5143 C C   . PRO C 3 457 ? 207.419 211.973 192.533 1.00 61.01 ? 457 PRO A C   1 
ATOM   5144 O O   . PRO C 3 457 ? 206.202 212.140 192.456 1.00 61.01 ? 457 PRO A O   1 
ATOM   5145 C CB  . PRO C 3 457 ? 208.783 213.135 190.766 1.00 61.01 ? 457 PRO A CB  1 
ATOM   5146 C CG  . PRO C 3 457 ? 208.611 213.120 189.284 1.00 61.01 ? 457 PRO A CG  1 
ATOM   5147 C CD  . PRO C 3 457 ? 207.360 212.345 189.045 1.00 61.01 ? 457 PRO A CD  1 
ATOM   5148 N N   . ASP C 3 486 ? 209.029 232.860 200.167 1.00 87.42 ? 486 ASP A N   1 
ATOM   5149 C CA  . ASP C 3 486 ? 209.519 233.792 199.158 1.00 87.42 ? 486 ASP A CA  1 
ATOM   5150 C C   . ASP C 3 486 ? 209.797 233.073 197.843 1.00 87.42 ? 486 ASP A C   1 
ATOM   5151 O O   . ASP C 3 486 ? 209.888 231.846 197.804 1.00 87.42 ? 486 ASP A O   1 
ATOM   5152 C CB  . ASP C 3 486 ? 210.781 234.502 199.649 1.00 87.42 ? 486 ASP A CB  1 
ATOM   5153 C CG  . ASP C 3 486 ? 210.942 235.885 199.048 1.00 87.42 ? 486 ASP A CG  1 
ATOM   5154 O OD1 . ASP C 3 486 ? 210.031 236.325 198.317 1.00 87.42 ? 486 ASP A OD1 1 
ATOM   5155 O OD2 . ASP C 3 486 ? 211.979 236.531 199.308 1.00 87.42 ? 486 ASP A OD2 1 
ATOM   5156 N N   . ILE C 3 487 ? 209.931 233.843 196.766 1.00 83.78 ? 487 ILE A N   1 
ATOM   5157 C CA  . ILE C 3 487 ? 210.116 233.296 195.428 1.00 83.78 ? 487 ILE A CA  1 
ATOM   5158 C C   . ILE C 3 487 ? 211.160 234.125 194.691 1.00 83.78 ? 487 ILE A C   1 
ATOM   5159 O O   . ILE C 3 487 ? 211.145 235.358 194.750 1.00 83.78 ? 487 ILE A O   1 
ATOM   5160 C CB  . ILE C 3 487 ? 208.782 233.260 194.653 1.00 83.78 ? 487 ILE A CB  1 
ATOM   5161 C CG1 . ILE C 3 487 ? 209.025 232.945 193.177 1.00 83.78 ? 487 ILE A CG1 1 
ATOM   5162 C CG2 . ILE C 3 487 ? 208.028 234.570 194.820 1.00 83.78 ? 487 ILE A CG2 1 
ATOM   5163 C CD1 . ILE C 3 487 ? 209.646 231.589 192.948 1.00 83.78 ? 487 ILE A CD1 1 
ATOM   5164 N N   . VAL C 3 488 ? 212.072 233.443 194.001 1.00 79.40 ? 488 VAL A N   1 
ATOM   5165 C CA  . VAL C 3 488 ? 213.109 234.080 193.199 1.00 79.40 ? 488 VAL A CA  1 
ATOM   5166 C C   . VAL C 3 488 ? 212.956 233.612 191.760 1.00 79.40 ? 488 VAL A C   1 
ATOM   5167 O O   . VAL C 3 488 ? 212.890 232.406 191.499 1.00 79.40 ? 488 VAL A O   1 
ATOM   5168 C CB  . VAL C 3 488 ? 214.518 233.759 193.732 1.00 79.40 ? 488 VAL A CB  1 
ATOM   5169 C CG1 . VAL C 3 488 ? 215.576 234.449 192.884 1.00 79.40 ? 488 VAL A CG1 1 
ATOM   5170 C CG2 . VAL C 3 488 ? 214.641 234.174 195.190 1.00 79.40 ? 488 VAL A CG2 1 
ATOM   5171 N N   . PHE C 3 489 ? 212.905 234.563 190.832 1.00 76.10 ? 489 PHE A N   1 
ATOM   5172 C CA  . PHE C 3 489 ? 212.737 234.230 189.424 1.00 76.10 ? 489 PHE A CA  1 
ATOM   5173 C C   . PHE C 3 489 ? 214.016 233.624 188.862 1.00 76.10 ? 489 PHE A C   1 
ATOM   5174 O O   . PHE C 3 489 ? 215.110 234.160 189.060 1.00 76.10 ? 489 PHE A O   1 
ATOM   5175 C CB  . PHE C 3 489 ? 212.351 235.473 188.625 1.00 76.10 ? 489 PHE A CB  1 
ATOM   5176 C CG  . PHE C 3 489 ? 211.393 236.383 189.340 1.00 76.10 ? 489 PHE A CG  1 
ATOM   5177 C CD1 . PHE C 3 489 ? 210.041 236.086 189.389 1.00 76.10 ? 489 PHE A CD1 1 
ATOM   5178 C CD2 . PHE C 3 489 ? 211.842 237.539 189.957 1.00 76.10 ? 489 PHE A CD2 1 
ATOM   5179 C CE1 . PHE C 3 489 ? 209.157 236.920 190.043 1.00 76.10 ? 489 PHE A CE1 1 
ATOM   5180 C CE2 . PHE C 3 489 ? 210.962 238.378 190.613 1.00 76.10 ? 489 PHE A CE2 1 
ATOM   5181 C CZ  . PHE C 3 489 ? 209.618 238.068 190.655 1.00 76.10 ? 489 PHE A CZ  1 
ATOM   5182 N N   . GLU C 3 490 ? 213.872 232.509 188.154 1.00 77.15 ? 490 GLU A N   1 
ATOM   5183 C CA  . GLU C 3 490 ? 214.984 231.819 187.517 1.00 77.15 ? 490 GLU A CA  1 
ATOM   5184 C C   . GLU C 3 490 ? 214.694 231.672 186.032 1.00 77.15 ? 490 GLU A C   1 
ATOM   5185 O O   . GLU C 3 490 ? 213.548 231.442 185.636 1.00 77.15 ? 490 GLU A O   1 
ATOM   5186 C CB  . GLU C 3 490 ? 215.217 230.442 188.151 1.00 77.15 ? 490 GLU A CB  1 
ATOM   5187 C CG  . GLU C 3 490 ? 216.430 229.700 187.610 1.00 77.15 ? 490 GLU A CG  1 
ATOM   5188 C CD  . GLU C 3 490 ? 216.938 228.639 188.567 1.00 77.15 ? 490 GLU A CD  1 
ATOM   5189 O OE1 . GLU C 3 490 ? 216.118 228.067 189.314 1.00 77.15 ? 490 GLU A OE1 1 
ATOM   5190 O OE2 . GLU C 3 490 ? 218.160 228.377 188.571 1.00 77.15 ? 490 GLU A OE2 1 
ATOM   5191 N N   . ASP C 3 491 ? 215.734 231.814 185.214 1.00 76.83 ? 491 ASP A N   1 
ATOM   5192 C CA  . ASP C 3 491 ? 215.562 231.750 183.768 1.00 76.83 ? 491 ASP A CA  1 
ATOM   5193 C C   . ASP C 3 491 ? 215.030 230.386 183.346 1.00 76.83 ? 491 ASP A C   1 
ATOM   5194 O O   . ASP C 3 491 ? 215.506 229.346 183.810 1.00 76.83 ? 491 ASP A O   1 
ATOM   5195 C CB  . ASP C 3 491 ? 216.888 232.043 183.070 1.00 76.83 ? 491 ASP A CB  1 
ATOM   5196 C CG  . ASP C 3 491 ? 217.341 233.474 183.266 1.00 76.83 ? 491 ASP A CG  1 
ATOM   5197 O OD1 . ASP C 3 491 ? 216.526 234.296 183.736 1.00 76.83 ? 491 ASP A OD1 1 
ATOM   5198 O OD2 . ASP C 3 491 ? 218.510 233.778 182.951 1.00 76.83 ? 491 ASP A OD2 1 
ATOM   5199 N N   . PHE C 3 492 ? 214.033 230.398 182.458 1.00 72.21 ? 492 PHE A N   1 
ATOM   5200 C CA  . PHE C 3 492 ? 213.409 229.160 182.004 1.00 72.21 ? 492 PHE A CA  1 
ATOM   5201 C C   . PHE C 3 492 ? 214.323 228.349 181.094 1.00 72.21 ? 492 PHE A C   1 
ATOM   5202 O O   . PHE C 3 492 ? 214.072 227.156 180.893 1.00 72.21 ? 492 PHE A O   1 
ATOM   5203 C CB  . PHE C 3 492 ? 212.090 229.481 181.290 1.00 72.21 ? 492 PHE A CB  1 
ATOM   5204 C CG  . PHE C 3 492 ? 211.314 228.269 180.859 1.00 72.21 ? 492 PHE A CG  1 
ATOM   5205 C CD1 . PHE C 3 492 ? 210.492 227.605 181.749 1.00 72.21 ? 492 PHE A CD1 1 
ATOM   5206 C CD2 . PHE C 3 492 ? 211.391 227.806 179.557 1.00 72.21 ? 492 PHE A CD2 1 
ATOM   5207 C CE1 . PHE C 3 492 ? 209.775 226.498 181.356 1.00 72.21 ? 492 PHE A CE1 1 
ATOM   5208 C CE2 . PHE C 3 492 ? 210.675 226.695 179.161 1.00 72.21 ? 492 PHE A CE2 1 
ATOM   5209 C CZ  . PHE C 3 492 ? 209.866 226.042 180.065 1.00 72.21 ? 492 PHE A CZ  1 
HETATM 5210 O O3  . ODN D 4 .   ? 217.330 201.891 156.497 1.00 77.01 ? 501 ODN A O3  1 
HETATM 5211 C C17 . ODN D 4 .   ? 217.241 201.531 157.651 1.00 77.01 ? 501 ODN A C17 1 
HETATM 5212 C C10 . ODN D 4 .   ? 216.058 201.746 158.582 1.00 77.01 ? 501 ODN A C10 1 
HETATM 5213 C C18 . ODN D 4 .   ? 215.207 203.013 158.366 1.00 77.01 ? 501 ODN A C18 1 
HETATM 5214 O O4  . ODN D 4 .   ? 215.999 204.124 158.539 1.00 77.01 ? 501 ODN A O4  1 
HETATM 5215 O O1  . ODN D 4 .   ? 214.204 203.016 159.365 1.00 77.01 ? 501 ODN A O1  1 
HETATM 5216 C C8  . ODN D 4 .   ? 213.305 201.913 159.315 1.00 77.01 ? 501 ODN A C8  1 
HETATM 5217 C C19 . ODN D 4 .   ? 214.452 203.072 157.022 1.00 77.01 ? 501 ODN A C19 1 
HETATM 5218 O O5  . ODN D 4 .   ? 215.263 203.485 155.959 1.00 77.01 ? 501 ODN A O5  1 
HETATM 5219 C C6  . ODN D 4 .   ? 213.705 201.740 156.798 1.00 77.01 ? 501 ODN A C6  1 
HETATM 5220 C C3  . ODN D 4 .   ? 212.398 201.837 155.956 1.00 77.01 ? 501 ODN A C3  1 
HETATM 5221 C C5  . ODN D 4 .   ? 212.734 202.399 154.571 1.00 77.01 ? 501 ODN A C5  1 
HETATM 5222 C C4  . ODN D 4 .   ? 211.284 202.730 156.518 1.00 77.01 ? 501 ODN A C4  1 
HETATM 5223 C C2  . ODN D 4 .   ? 211.854 200.423 155.711 1.00 77.01 ? 501 ODN A C2  1 
HETATM 5224 C C1  . ODN D 4 .   ? 212.350 199.332 156.644 1.00 77.01 ? 501 ODN A C1  1 
HETATM 5225 C C13 . ODN D 4 .   ? 218.320 200.776 158.381 1.00 77.01 ? 501 ODN A C13 1 
HETATM 5226 C C14 . ODN D 4 .   ? 218.959 199.652 157.586 1.00 77.01 ? 501 ODN A C14 1 
HETATM 5227 C C12 . ODN D 4 .   ? 217.665 200.444 159.732 1.00 77.01 ? 501 ODN A C12 1 
HETATM 5228 C C11 . ODN D 4 .   ? 216.766 201.671 159.954 1.00 77.01 ? 501 ODN A C11 1 
HETATM 5229 O O2  . ODN D 4 .   ? 217.519 202.831 160.191 1.00 77.01 ? 501 ODN A O2  1 
HETATM 5230 C C15 . ODN D 4 .   ? 216.812 199.157 159.712 1.00 77.01 ? 501 ODN A C15 1 
HETATM 5231 C C16 . ODN D 4 .   ? 215.327 199.423 159.459 1.00 77.01 ? 501 ODN A C16 1 
HETATM 5232 C C9  . ODN D 4 .   ? 215.115 200.489 158.377 1.00 77.01 ? 501 ODN A C9  1 
HETATM 5233 C C7  . ODN D 4 .   ? 213.646 200.977 158.153 1.00 77.01 ? 501 ODN A C7  1 
HETATM 5234 C C   . ODN D 4 .   ? 212.665 199.795 158.063 1.00 77.01 ? 501 ODN A C   1 
HETATM 5235 O O   . ODN D 4 .   ? 211.461 200.136 158.719 1.00 77.01 ? 501 ODN A O   1 
# 
